bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanically Robust, Flexible, Fast Responding Temperature Sensor and High‐Resolution Array with Ionically Conductive Double Cross‐Linked Hydrogel
Authors: Zhang Jing , Yan Ke , Huang Jinrong , Sun Xidi , Li Jiean , Cheng Yan , Sun Yuqiong , Shi Yi , Pan Lijia 
Published: January 2024

AbstractHydrogel‐based sensing devices show potential in wearable electronics. However, most hydrogels are mechanically weak, bringing functional stability problems in real usage environment that may interact with occasionally external forces. There are demands to develop robust hydrogel‐based devices with good performances. Here, a highly sensitive temperature sensor with robust, ionic conductive, and double cross‐linked polyacrylamide‐sodium alginate hydrogel is developed. It is found that ions with larger radius show higher sensitivity to temperature changes (e.g., Ba2+) in the hydrogel, because ion movement is dependent with ion sizes. The sensor shows advantages of fast response (2.02 s of 40 °C temperature difference), wide sensing range (22–100 °C), and high robustness (withstanding 2000 cyclic compression and 175 N m−1 for 180° anti‐peeling test). The wearable sensor can effectively distinguish the temperatures of various body parts (0.9 °C temperature difference) and monitor respiration (0.5 °C temperature difference) in real‐time. A wearable 5×5 sensing array is developed for direct human‐body temperature mapping, achieving an optimum resolution of ≈0.15 mm−1 and enabling a clear mapping of superficial vascular pathways at the wrist. This study provides a practical and optimized approach for the implementation of wearable conductive hydrogel‐based devices in the field of human health.
Metformin‐Mediated Immunosuppressive Microenvironment Remodeling in Combination with Chemotherapy via a Spatial‐Specific Multi‐Responsive Carrier‐Free Self‐Assembled Nanoparticle
Authors: Song Yujun , Du Yufan , Hu Chuan , Lei Lei , Yang Lianyi , Wang Xiaorong , Jiang Chaoqing , Gao Huile 
Published: January 2024

AbstractThe complex tumor immune pathology requires a precise spatial‐control release of the combination drugs, but most multi‐drug loaded nanoparticles release all drugs simultaneously in the tumor microenvironment (TME), making them difficult to reach the exact action site. To address the spatial specific release of drugs, a carrier‐free self‐assembled multi‐responsive nanodrug delivery system is designed, in which p‐phthalaldehyde (p‐APA) and dithiodipropionic acid are used to connect metformin (MET) and 7‐ethyl‐10‐hydroxycamptothecin (SN38) through a matrix metalloproteinase‐2 (MMP‐2) responsive peptide, and dipyridamole (DIP) is further loaded (MA‐GPLGVRGDK‐SS‐SN38@DIP, MR NPs). The MR NPs first target tumor by enhanced permeability and retention effect, then the highly expressed MMP‐2 at tumor site cleaves GPLGVRGDK, breaking the nanoparticle into three parts—DIP, MA‐GPLG, and VRGDK‐SS‐SN38. DIP automatically binds with platelets in TME, inhibiting their function and restraining tumor metastasis. MA‐GPLG releases MET in response to the acidic TME to reverse the immunosuppressive networks through PD‐L1 downregulation and M2‐like macrophages repolarization. Moreover, VRGDK‐SS‐SN38 binds to the overexpressed integrin αvβ3 receptor to achieve tumor cells specific delivery and precise killing. Overall, this study offers an intelligent spatial‐specific multi‐responsive carrier‐free drug delivery system in breast cancer, which releases drug spatial specifically, therefore reverses the tumor immunosuppressive microenvironment and inhibits metastasis.
Bio‐inspired Thermal Diode with Anti‐Gravity Unidirectional Heat Transfer and Switchable Functionality for Intelligent Thermal Management
Authors: Zhang Liwen , Zhang Ye , Li Xinghao , Zhang Chaoqi , Liu Xiaolin , Yang Xiangdong , Zhao Zehui , Chen Huawei 
Published: January 2024

AbstractPhase‐change thermal diodes with asymmetric and adjustable heat transfer capacity exhibit great application prospects in spacecraft heat management and solar energy storage. Current heat modulation strategies mainly depend on the anisotropic assistance from gravity and the rectification ratio can hardly be adjusted due to the immobilized inner structures. Here, a novel bioinspired thermal diode vapor chamber has been carried out with magnetic microgroove cones array sealed between two copper plates, where the evaporating plate with porous copper foam can reserve water and the condensing plate with patterned wettability can coagulate vapor into droplets at designated spot. With microgroove cones rooting from the evaporating plate and their tips contacting the condensing plate, these cones can directionally and rapidly transport condensed liquid from the condensing plate to evaporating plate under the unbalanced strong capillarity while prohibiting water flowing backward. This eventually leads to unidirectional liquid‐vapor circulation and anti‐gravitational directional heat transferring with a rectification ratio as high as 7.4. Such flowing of liquid can also be regulated by magnetically controlling the bending of cones to realize switched ON–OFF of thermal diode and achieve further modulation of heat management. This bioinspired thermal diode vapor chamber provides new ideas for intelligent thermal management systems.
2D Double Heterostructure Infrared Photodetector with Type‐III Band Alignment by Incorporating Bi2Se3 Layer
Authors: Ma Jingyi , Chen Shengdi , Zhao Lei , Chen Jianru , Lan Zhibin , Yang Mengmeng , Sun Yiming , Zheng Zhaoqiang , Gao Wei , Li Jingbo 
Published: January 2024

AbstractTwo‐dimensional (2D) self‐powered photodetectors have attracted considerable attention due to their exceptional sensitivity, and low dark current. However, the poor responsivity of single heterojunctions with type‐III band alignment is primarily attributed to band‐to‐band tunneling. The implementation of a double heterojunction has the potential to enhance photovoltaic responsivity, enable broadband detection, and improve response speed. In this study, a back‐to‐back type‐III band alignment based on SnSe2/Bi2Se3/MoTe2 double heterostructure by dry transfer method is designed. As a result, it exhibited an impressive photovoltaic performance in the overlapping region. Achieving a maximum responsivity (R), external quantum efficiency (EQE), photoelectric conversion efficiency (PCE), and specific detectiviy (D*) of 493 mA W−1, 76 %, 3 % and 1.8 × 1011 Jones at a gate voltage (Vg) of 60 V under 808 nm illumination. It can be ascribed to the effective depletion region at the SnSe2/Bi2Se3 interface and the reversed band edge from depletion to accumulation mode at Bi2Se3/MoTe2 interface. In addition, a faster response speed of 553/583 µs and a lower dark current of 2.9 pA can be obtained. Moreover, this double heterostructure achieves better photovoltaic performance with Vg compared to the single MoTe2/SnSe2 heterojunction. These results demonstrates the potential as a candidate for back‐to‐back type‐III band alignment in low power optoelectronics.
A Review on Sensor‐Integrating Machine Elements
Authors: Kirchner Eckhard , Wallmersperger Thomas , Gwosch Thomas , Menning Johannes D. M. , Peters Julian , Breimann Richard , Kraus Benjamin , Welzbacher Peter , Küchenhof Jan , Krause Dieter , Knoll Erich , Otto Michael , Muhammedi Benjamin , Seltmann Stephanie , Hasse Alexander , Schäfer Günter , Lohrengel Armin , Thielen Stefan , Stiemcke Yvo , Koch Oliver , Ewert Arthur , Rosenlöcher Thomas , Schlecht Berthold , Prokopchuk Artem , Henke Ernst‐Friedrich Markus , Herbst Felix , Matthiesen Sven , Riehl David , Keil Ferdinand , Hofmann Klaus , Pape Florian , Konopka Dennis , Poll Gerhard , Steppeler Tobias , Ottermann Rico , Dencker Folke , Wurz Marc C. , Puchtler Steffen , Baszenski Thao , Winnertz Martin , Jacobs Georg , Lehmann Benjamin , Stahl Karsten 
Published: January 2024

AbstractThis contribution summarizes the current state of research regarding so‐called sensor‐integrating machine elements as an enabler of digitalization in mechanical engineering and——if available—their application in industry. The focus is on the methodical aspects of the development of these machine elements in general as well as specific sensor‐integrating machine elements that are either already in use or currently under development. Developmental aspects include the robust design of initially evaluated concepts for sensor‐integrating machine elements as well as their modularization. Smart materials with sensory functions are included in the analysis as well as the differentiation with regard to add‐on sensors. The aim of the authors interlinked by a special research program funded by the German Research Foundation (DFG) is to facilitate the exchange with other researchers with the help of the comprehensive overview given in this contribution. The contribution concludes with a brief discussion of open challenges, such as the energy supply and data transfer in rotating systems and also data security.
Unveiling The Multifunction of Beaded Stream‐Like Co9Se8 Catalysts for Water Splitting, Reactive Oxygen Species Scavenging, and Hydrogen Anti‐Inflammation
Authors: Luo Pan , Wang Honglei , Wen Xue , Luo Xianzhu , Xu Peng 
Published: January 2024

AbstractThe electrocatalytic preparation of hydrogen at different pH values not only achieves excellent device performance but also promotes the application of reactive oxygen species (ROS) clearance and hydrogen anti‐inflammation. However, it is difficult to develop materials that simultaneously achieve these excellent properties. Herein, the preparation of beaded necklace‐like Co9Se8 microspheres using a general and facile synthetic strategy is reported. The Co9Se8‐modified electrode has three applications: efficient water splitting for enhanced performance, ROS scavenging, and hydrogen anti‐inflammatory activity. Experiments, high‐angle‐annular‐dark‐field scanning transmission electron microscopy, and density functional theory calculations indicate that the reconstructed Co(OH)2 plays a vital role in the oxygen evolution reaction and that the transition from *O to *OOH is the actual rate‐determining step. The Co9Se8 material, with its unique beaded necklace‐like structure, exhibits exceptional hydrogen production capabilities in phosphate buffer solution (pH 7.4). In particular, hydrogen produce under neutral conditions can effectively reduce ROS levels and significantly inhibit inflammation‐related pathological processes, playing a unique antioxidant and anti‐inflammatory role at the cellular level. The obtained results indicate that the as‐synthesized Co9Se8 is more suitable for water splitting, ROS scavenging, and hydrogen anti‐inflammatory applications, outperforming other transition metal electrodes and rendering practical industrial and clinical applications.
Fundamentals and Rational Design of Heterogeneous C‐N Coupling Electrocatalysts for Urea Synthesis at Ambient Conditions
Authors: Wan Yuchi , Zheng Muyun , Yan Wei , Zhang Jiujun , Lv Ruitao 
Published: January 2024

AbstractElectrocatalytic C‐N coupling reaction is regarded as a promising strategy for achieving clean and sustainable urea production by coreducing CO2 and nitrogen species, thus contributing to carbon neutrality and the artificial nitrogen cycle. However, restricted by the sluggish adsorption of reactants, competitive side reactions, and multistep reaction pathways, the electrochemical urea production suffers from a low urea yield rate and low selectivity so far. In order to comprehensively improve urea synthesis performance, it is crucial to develop highly efficient catalysts for electrochemical C‐N coupling. In this article, the catalyst‐designing strategies, C‐N coupling mechanisms, and fundamental research methods are reviewed. For the coreduction of CO2 and different nitrogen species, several prevailing reaction mechanisms are discussed. With the aim of establishing the standard research system, the fundamentals of electrocatalytic urea synthesis research are introduced. The most important catalyst‐designing strategies for boosting the electrocatalytic urea production are discussed, including heteroatom doping, vacancy engineering, crystal facet regulation, atom‐scale modulation, alloying and heterostructure construction. Finally, the challenges and perspectives are proposed for future industrial applications of electrochemical urea production by C‐N coupling.
Multifunctional Double Layer Based on Regional Segregation for Stabilized and Dendrite‐Free Solid‐State Li Batteries
Authors: Bai Xiaoming , Zhao Guangyu , Yang Guiye , Wang Ming , Lin Qianru , Zhang Naiqing 
Published: January 2024

AbstractThe Li dendrite problem triggered by the inhomogeneous deposition of Li and the reduction of Li+ in the electrolyte has seriously hindered the practical application of garnet‐based solid‐state batteries. To address this issue, a multifunctional double layer (MDL) based on the phenomenon of segregation during welding is introduced between the garnet and the Li anode. BiLi3/LiCl3 interlayer with a double‐layer structure is constructed by modulating the cooling rate. The LiCl3 enriched on the electrolyte side exhibits extremely low electronic conductivity, effectively blocking electrons and preventing electrolyte attack. On the anode side, the BiLi3‐enriched layer regulates local current distribution, ensuring uniform deposition/exfoliation of Li and preventing dendrite formation at the interface. Furthermore, this welding‐based preparation method achieves a strong and secure connection between the metal electrode and the ceramic electrolyte. Hence, this Li|LLZTO‐MDL|Li battery with double‐layer special structural interfacial modification can realize a high critical current density of 2.9 mA cm−2 and can be stably cycled for more than 10 000 h at 0.3 mA cm−2.
Prognostic factors of conversion surgery for stage IV gastric cancer: A multi‐institutional retrospective analysis
Authors: Takeno Atsushi , Motoori Masaaki , Kishi Kentaro , Omori Takeshi , Hirao Motohiro , Masuzawa Toru , Fujitani Kazumasa , Yamamato Kazuyoshi , Kurokawa Yukinori , Doki Yuichiro 
Published: January 2024

AbstractBackgroundConversion surgery (CS) is a highly anticipated strategy for stage IV advanced gastric cancer (AGC) with a good response to chemotherapy. However, prognostic factors limiting R0 resection remain unclear. In this multi‐institutional study, we investigated the clinical outcomes of CS for stage IV AGC and the prognostic factors of CS‐limiting R0 resection and analyzed them according to metastatic patterns.MethodsClinical data on 210 patients who underwent CS for stage IV AGC at six institutions between 2007 and 2017 were retrospectively retrieved. The patient background, preoperative treatment, operative outcomes, and survival times were recorded. Prognostic factors for overall and recurrence‐free survival were investigated using univariate and multivariate analyses for patients who underwent R0 resection.ResultsR0 resection was achieved in 146 (70%) patients. The median survival time was 32 months, and the 3‐year survival rate was 45%. Patients who achieved R0 resection had significantly longer survival than those with R1/2 resection (median survival time: 41.5 months vs. 20.7 months). Multivariate analysis identified pathological N positivity for overall and relapse‐free survival and pathological T4 for relapse‐free survival as significant independent poor prognostic factors of R0 resected patients. There was no significant difference in survival among the peritoneum, liver, and lymph node groups regarding the initial metastatic sites.ConclusionsCS with R0 resection for patients with stage IV AGC can lead to longer survival. Patients with pathological T4 and pathological N positivity were eligible for intensive adjuvant therapy after CS with R0 resection.
Expert consensus guidelines: Intravenous iron uses, formulations, administration, and management of reactions
Authors: Van Doren Layla , Steinheiser Marlene , Boykin Kristen , Taylor Kristine J. , Menendez Monica , Auerbach Michael 
Published: January 2024

AbstractIntravenous iron has become an essential component for the treatment of iron deficiency and iron deficiency anemia. Individuals administering Intravenous iron should have knowledge in intravenous iron administration, including a pre‐infusion assessment to evaluate infusion reaction risks, pre‐ and post‐infusion monitoring, identification of and management of infusion reactions, accurate documentation of these reactions, laboratory monitoring and recognition and management of treatment‐emergent hypophosphatemia. This comprehensive consensus provides step‐by‐step guidance and tools for practitioners to promote safe delivery of intravenous iron, recognition, and management of infusion reactions and treatment‐emergent hypophosphatemia.
Late‐onset and long‐lasting neutropenias in the young: A new entity anticipating immune‐dysregulation disorders
Authors: Fioredda F. , Beccaria A. , Casartelli P. , Turrini E. , Contratto C. , Giarratana M. C. , Bagnasco F. , Saettini F. , Pillon M. , Marzollo A. , Zanardi S. , Civino A. , Onofrillo D. , Lanciotti M. , Ceccherini I. , Grossi A. , Coviello D. , Terranova P. , Lupia M. , Del Borrello G. , Uva P. , Cangelosi D. , Cavalca G. , Miano M. , Dufour C. 
Published: January 2024

AbstractThis study identifies a new chronic form of immune neutropenia in the young with or without detectable indirect anti‐neutrophil antibodies, characterized by mild/moderate neutropenia low risk of severe infection (14%), tendency to develop autoimmune phenomena over the course of the disease (cumulative incidence of 58.6% after 20 years of disease duration), leukopenia, progressive reduction of absolute lymphocyte count and a T‐ and B‐cell profile similar to autoimmune disorders like Sjogren syndrome, rheumatoid arthritis, and systemic lupus erythematosus (increased HLADR+ and CD3 + TCRγδ cells, reduced T regulatory cells, increased double‐negative B and a tendency to reduced B memory cells). In a minority of patients, P/LP variants related to primary immuno‐regulatory disorders were found. This new form may fit the group of “Likely acquired neutropenia,” a provisional category included in the recent International Guidelines on Diagnosis and Management of Neutropenia of EHA and EUNET INNOCHRON ACTION 18233. The early recognition of this form of neutropenia would help clinicians to delineate better specific monitoring plans, genetic counseling, and potentially targeted therapies.
Supports desired by Aboriginal and Torres Strait Islander males in fatherhood: Focussing on the social and cultural determinates of health and well‐being
Authors: Prehn Jacob , Guerzoni Michael Andre , Peacock Huw , Adams Mick , Williamson Bhiamie , Collard Len , Canuto Kootsy 
Published: January 2024

AbstractIn Australia, there is insufficient exploration and understanding of how we can strengthen the critical role played by Indigenous fathers. This paper argues that for Indigenous fathers to feel supported in childrearing, greater attention must be given to their social and cultural determinants of health and well‐being. To gain insights into the challenges experienced by Indigenous fathers and the support they require in fatherhood, we primarily apply thematic analysis to data from the Longitudinal Study of Indigenous Children (LSIC). The findings reveal that most fathers identify a social or cultural health and well‐being determinant challenging their fatherhood journey. We examine these results and suggest why and how appropriately focussing on the social and cultural determinants of health and well‐being will enhance and support Indigenous men in fatherhood.
More than a piece of cake: Noun classifier processing in primary progressive aphasia
Authors: Tee Boon Lead , Li‐Ying Lorinda Kwan‐Chen , Chen Ta‐Fu , Yan Connie TY , Tsoh Joshua , Chan Andrew Lung‐Tat , Wong Adrian , Lo Raymond Y. , Lu Chien Jung , Sun Yu , Wang Pei‐Ning , Lee YiChen , Chiu Ming‐Jang , Allen Isabel Elaine , Battistella Giovanni , Bak Thomas H. , Chuang Yu‐Chen , García Adolfo M. , Gorno‐Tempini Maria Luisa 
Published: January 2024

AbstractINTRODUCTIONClinical understanding of primary progressive aphasia (PPA) has been primarily derived from Indo‐European languages. Generalizing certain linguistic findings across languages is unfitting due to contrasting linguistic structures. While PPA patients showed noun classes impairments, Chinese languages lack noun classes. Instead, Chinese languages are classifier language, and how PPA patients manipulate classifiers is unknown.METHODSWe included 74 native Chinese speakers (22 controls, 52 PPA). For classifier production task, participants were asked to produce the classifiers of high‐frequency items. In a classifier recognition task, participants were asked to choose the correct classifier.RESULTSBoth semantic variant (sv) PPA and logopenic variant (lv) PPA scored significantly lower in classifier production task. In classifier recognition task, lvPPA patients outperformed svPPA patients. The classifier production scores were correlated to cortical volume over left temporal and visual association cortices.DISCUSSIONThis study highlights noun classifiers as linguistic markers to discriminate PPA syndromes in Chinese speakers.Highlights
Noun classifier processing varies in the different primary progressive aphasia (PPA) variants. Specifically, semantic variant PPA (svPPA) and logopenic variant PPA (lvPPA) patients showed significantly lower ability in producing specific classifiers. Compared to lvPPA, svPPA patients were less able to choose the accurate classifiers when presented with choices.
In svPPA, classifier production score was positively correlated with gray matter volume over bilateral temporal and left visual association cortices in svPPA. Conversely, classifier production performance was correlated with volumetric changes over left ventral temporal and bilateral frontal regions in lvPPA.
Comparable performance of mass and count classifier were noted in Chinese PPA patients, suggesting a common cognitive process between mass and count classifiers in Chinese languages.