bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advisory board resolution: The role of the adjuvant atezolizumab plus bevacizumab in patients with hepatocellular carcinoma at high risk of recurrence following surgical resection or ablation
Authors: Breder V. V. , Pokataev I. A. , Petkau V. V. , Fedyanin M. Yu. , Ledin E. V. , Zagainov V. E. , Shapoval S. V. , Granov D. A. , Balakhnin P. V. , Kudashkin N. E. , Pogrebnyakov I. V. , Popova N. V. , Moroz E. A. 
Published: January 2024

MEETING DATE: July 7, 2023ITEMS ON THE AGENDA:1. The role of the adjuvant atezolizumab plus bevacizumab in patients with hepatocellular carcinoma (HCC) at high risk of recurrence following surgical resection or ablation. Profile of the patient who will benefit the most from this therapy.2. To evaluate the prospects for therapeutic options for patients with early HCC in Russia.Liver cancer remains a public health concern globally, with an increasing trend in the number of incident cases worldwide. Early, precise diagnosis and timely treatment contribute to the improvement in overall and relapse-free survival. It is important that the entire arsenal of local treatments (resection, ablation and liver transplantation) can be applied in cases when HCC is detected at a very early and early stage of the disease. Tumour recurrence after surgical treatment or ablation is a complex and underexplored problem in the treatment of patients with HCC. Many factors that can predict the risk of relapse after surgical treatment have been described: tumour size >5 cm, >3 foci, micro- or macrovascular (Vp1-2) invasion, poor degree of tumour differentiation (G3-4). Our advisory board tried to identify the most important risk factors for early relapse, and to determine the role and impact of the results of the first positive clinical trial focused on the issue of early HCC, IMbrave050: a phase 3 trial of adjuvant atezolizumab + bevacizumab vs active surveillance in patients with HCC at high risk of disease recurrence following resection or ablatio.
Efficacy of immunotherapy in patients with non-small cell lung cancer
Authors: Lyadova M. A. , Denisova E. A. , Fedorinov D. S. , Esakov Yu. S. , Orlova A. S. , Vozniuk D. A. , Lyadov K. V. , Galkin V. N. 
Published: January 2024

Introduction. Non-small cell lung cancer (NSCLC) is a form of lung cancer with high incidence and low overall survival. Immunotherapy is a promising treatment method for which the selection of optimal treatment regimens for each individual patient is important.Aim. To evaluate the effectiveness and safety of immune checkpoint inhibitors (ICIs) in patients with advanced NSCLC.Materials and methods. The study included 247 patients (190 men and 57 women) aged 37 to 87 years who received ICIs as monotherapy with nivolumab (n = 58; 23.4%), pembrolizumab (n = 78; 31.6%) and atezolizumab (n = 13; 5.3%), and in the form of combination chemoimmune therapy (n = 98; 39.7%). The objective response of the tumor to treatment was recorded in the presence of partial or complete regression of the tumor. The tumor response to treatment was determined in accordance with the iRECIST criteria.Results. Objective response was achieved in 20.6% of patients, of which 13.7% were on the first line setting, and 7% of patients were on the 2nd or more line setting. Disease control was recorded in 83.3% of patients. Patients receiving combination chemoimmune therapy had a better response to treatment than those receiving monotherapy (χ2 = 9.309; p = 0.020). Grade 3–4 immuno-related adverse events were observed only in 5 (2.02%) patients.Conclusions. NSCLC immunotherapy allows to achieve high rates of objective response and disease control (20.6 and 83.3%, respectively), with a small number of grade 3–4 immuno-related adverse events (2.02% according to our data), which indicates an acceptable safety profile.
Studi Rehabilitasi Bendung Untuk Kebutuhan Air Irigasi Pada D.I Gumbasa Kabupaten Sigi, Provinsi Sulawesi Tengah
Authors: Wahyuni Sri , Moch. Sholichin  , Anggara Wiyono Wit Saputra  
Published: January 2024

Tsunami dan gempa bumi yang terjadi di daerah Sulawesi Tengah yang meliputi Kota Palu, Kabupaten Sigi, Kabupaten Donggala, serta wilayah sekitarnya pada tanggal 28 September 2018 berdampak pada kerusakan Bendung Gumbasa. Studi ini bertujuan untuk memperoleh dimensi Bendung Gumbasa serta stabilitas bendung yang aman terhadap kondisi daerah studi. Studi terdiri dari beberapa kajian yakni analisa hidrologi, analisa neraca air, perencanaan dimensi bangunan utama Bendung Gumbasa serta analisa stabilitas bendung. Hasil studi menunjukkan dimensi bendung yang sesuai kondisi daerah studi yakni tinggi bendung sebesar 3,64 m, lebar efektif bendung 67,248 m, mercu bendung tipe OGEE III, elevasi mercu bendung +92,400 m, dengan peredam energi USBR IV, lebar kantong lumpur sebesar 21,992 m, panjang kantong lumpur sebesar 261,706 m, serta volume kantong lumpur sebesar 3396,334 m3. Hasil analisa stabilitas bendung bisa dipahami bahwasanya desain saluran pelimpah terlindung dari terguling, longsor, dan gempa bumi dalam segala situasi. Sehingga bendungan ini layak dibangun.
Анализ эффективности взаимодействия участников при реализации проектов в рамках программы реновации на примере города Москвы
Authors: Луняков Михаил Александрович , Кирпиченков Андрей Андреевич 
Published: January 2024

Одним из важнейших направлений социально-экономической политики каждого государства является обеспечение граждан безопасными и комфортными жилищными условиями, которые бы отвечали требованиям не только актуальных норм и правил, но и сложившимся требованиям современного общества. С целью улучшения жилищных условий и обновления ветхого и аварийного жилья ведется программа реновации жилой застройки. Одной из особенностей представленного во многих городах Российских Федерации жилого фонда является большое и, зачастую, преобладающее количество жилых домов, построенных в период с 1958 по 1967 гг., в период индустриального домостроения. В соответствии с действующими нормативными актами срок эксплуатации данных домов составляет до 70 лет при условии своевременного обслуживания. Это означает, что в ближайшие 10–15 лет общее состояние жилищного фонда может существенно ухудшиться и произойдет резкое увеличение ветхого и аварийного жилья. С целью не допустить массового появления аварийных зданий, для которых на данном этапе их жизненного цикла капитальный ремонт нецелесообразен, реализуется программа реновации жилой застройки. Главной задачей данной программы является модернизация существующего жилищного фонда и обновление среды жизнедеятельности с целью приведения его в соответствие со стандартами качества, обеспечивающими комфортные условия проживания.
В реализации программы реновации жилой застройки задействованы многие участники: от государственных структур до локальных подрядных организаций. Такой широкий круг участников требует максимально слаженной взаимной работы для достижения всех поставленных задач. Но, как показала практика, не всегда участники действуют слаженно, что приводит к различным последствиям, выраженным в существенном увеличении стоимости или сроков строительства. Тем самым необходима тщательная проработка действующего порядка взаимодействия участников с целью выявления возможных проблем и анализа для совершенствования механизма управления и взаимодействия участников реализации программы.
Caracterização da cobertura vacinal no município de Pedreiras (MA) nos anos de 2021 e 2022
Authors: Moraes Inaldo Kley do Nascimento , Anjos Tiago Sá dos 
Published: January 2024

Introdução: A vacinação é um pilar fundamental da saúde pública, desempenhando um papel crucial na prevenção de doenças contagiosas e na proteção da comunidade. O Brasil tem uma longa história de programas de vacinação bem-sucedidos, mas a manutenção de altas taxas de cobertura vacinal é fundamental para garantir a eficácia desses esforços de saúde pública. Objetivo: Caracterizar a cobertura vacinal no município de Pedreiras, localizado no estado do Maranhão, durante os anos de 2021 e 2022. Metodologia: Trata-se de um estudo ecológico, com abordagem de série temporal. Os dados obtidos foram referentes as doses de vacinas administradas, sem intervalo de idade no município de Pedreiras – MA, referente aos anos de 2021 e 2022 , foram coletados no site oficial do DATASUS/TabNet no período de setembro a agosto de 2023, sendo tabulados por meio do programa Microsoft Excel 2010®, analisados por estatísticas descritivas simples. Resultados: As vacinas que tiveram maior aumento na cobertura vacinal foram: Rotavírus Humano (+16,83%), Hepatite B (+16,71%), Penta (+16,71%), Pneumocócica (+14,92%), Poliomielite (+18,69%) e Tríplice Viral D1 (+22,07%). As vacinas que tiveram maior redução na cobertura vacinal foram: BCG (-6,44%), Hepatite B em crianças até 30 dias (-4,94%), Poliomielite 4 anos (-2,6%), Hepatite A (-17,79%), Poliomielite (1º ref) (-11,84%) e Dupla adulto e tríplice acelular gestante (-24,79%). A cobertura vacinal acima de 95% em ambos os anos foram: BCG e Hepatite B em crianças até 30 dias. As vacinas que tiveram cobertura vacinal abaixo de 50% em ambos os anos foram: Tetra Viral (SRC+VZ), Poliomielite 4 anos e dTpa gestante. Considerações finais :A análise comparativa da cobertura vacinal em Pedreiras (MA) nos anos de 2021 e 2022 revela um cenário complexo, marcado por desafios persistentes e algumas melhorias nos programas de imunização. O município enfrenta obstáculos na manutenção de coberturas ideais, evidenciados pelos declínios em vacinas cruciais, como Hepatite A e B, possivelmente relacionados a fatores socioeconômicos, logísticos e de conscientização. Palavras -chave: Vacina; Caracterização; Cobertura.
Increasing Client Fraud Risk Disclosure with Minimization Techniques
Authors: Eutsler Jared , Fleming A. Scott , Holderness D. Kip , Jones Megan M. 
Published: January 2024

SYNOPSIS
Auditing standards require auditors to conduct fraud inquiries as part of their risk assessment process. During fraud inquiries, auditors frequently ask client personnel directly about “fraud, alleged fraud, or suspected fraud,” using standard language taken from AS 2110. However, guidance from the Center for Audit Quality (CAQ) suggests that avoiding the word “fraud” results in greater disclosure regarding fraud risk. Although untested, the CAQ’s conjecture is supported by literature in psychology and criminology, which suggests that minimizing the seriousness of the offense (i.e., minimization) increases disclosure. This study examines two minimization strategies. The first involves replacing the word “fraud” with “questionable behavior.” The second employs social comparison to increase the perceived frequency that clients report misconduct to auditors. Experimental results suggest that either strategy increases client reporting intentions relative to a control condition using the language prescribed by AS 2110. Our findings may help auditors conduct more effective fraud inquiries.
Data Availability: Data are available from the authors.
JEL Classifications: M42; M48.
Performance of Artificial Intelligence in Detecting Diabetic Macular Edema From Fundus Photography and Optical Coherence Tomography Images: A Systematic Review and Meta-analysis
Authors: Lam Ching , Wong Yiu Lun , Tang Ziqi , Hu Xiaoyan , Nguyen Truong X. , Yang Dawei , Zhang Shuyi , Ding Jennifer , Szeto Simon K.H. , Ran An Ran , Cheung Carol Y. 
Published: January 2024

BACKGROUND
Diabetic macular edema (DME) is the leading cause of vision loss in people with diabetes. Application of artificial intelligence (AI) in interpreting fundus photography (FP) and optical coherence tomography (OCT) images allows prompt detection and intervention.

PURPOSE
To evaluate the performance of AI in detecting DME from FP or OCT images and identify potential factors affecting model performances.

DATA SOURCES
We searched seven electronic libraries up to 12 February 2023.

STUDY SELECTION
We included studies using AI to detect DME from FP or OCT images.

DATA EXTRACTION
We extracted study characteristics and performance parameters.

DATA SYNTHESIS
Fifty-three studies were included in the meta-analysis. FP-based algorithms of 25 studies yielded pooled area under the receiver operating characteristic curve (AUROC), sensitivity, and specificity of 0.964, 92.6%, and 91.1%, respectively. OCT-based algorithms of 28 studies yielded pooled AUROC, sensitivity, and specificity of 0.985, 95.9%, and 97.9%, respectively. Potential factors improving model performance included deep learning techniques, larger size, and more diversity in training data sets. Models demonstrated better performance when validated internally than externally, and those trained with multiple data sets showed better results upon external validation.

LIMITATIONS
Analyses were limited by unstandardized algorithm outcomes and insufficient data in patient demographics, OCT volumetric scans, and external validation.

CONCLUSIONS
This meta-analysis demonstrates satisfactory performance of AI in detecting DME from FP or OCT images. External validation is warranted for future studies to evaluate model generalizability. Further investigations may estimate optimal sample size, effect of class balance, patient demographics, and additional benefits of OCT volumetric scans.
PERANCANGAN MEJA SLIDER PALET PAVING BLOK MENGGUNAKAN METODE ERGONOMIC FUNCTION DEPLOYMENT (EFD) DI PT. DIAN NUSWANTORO REKAYASA TEKNOLOGI
Authors: Aji Chandra Wahyu , Wijaya Dewa Kusuma 
Published: January 2024

Dikarenakan banyaknya minat pengguna dalam penggunaan paving membuat produksi paving membludak dan banyak pesanan menyebabkan produsen atau karyawan pembuat paving menjadi kwalahan dikarenakan masih manualnya pengangkut paving yang keluar dari mesin produksi ke tempat penjemuran paving, dengan kira kira sekali produksi ± 100kg/pallet dan sehari bisa menghasilkan 20-25 pallet secara terus menerus dengan diangkat menggunakan tangan oleh 2-3 orang penggangkat. Hal ini sangat berbahaya dan dapat menyebabkan cidera jika terus – menerus dilakukan dan proses produksi juga akan menjadi lebih lama.Pada permasalahan tersebut dibutuhkan meja Slide yang dapat digunakan untuk mempermudah pekerja pembuat paving untuk menggangkat pallet.
Analisa indeks postur tubuh pekerja di PT Direct menggunakan Loading on the Upper Body Assessment (LUBA). Kemudian dilakukan perancangan alat bantu kerja meja menggunakan metode Ergonomic Function Deployment (EFD). Alat Bantu Kerja Meja Slider yang dirancang sangat efisien, karena proses penjemuran menjadi lebih cepat dengan perbandingan waktu penjemuran 1 jam mendapatkan selisih dari yang sebelum menggunakan alat 24 pallet dan setelah menggunakan jadi 60 pallet selama 1 jam jadi efisiensi sebesar 60%.
Analisis Paparan Panas Terhadap Beban Mental Pekerja Bagian Produksi Dengan Metode National Aeronatics And Space Administration Task Load Index (NASA TLX)
Authors: Asri Vikha Indira , Huda Mahabib Miftahul , Sokhibi Akh. 
Published: January 2024

Lingkungan kerja yang baik dapat mempengaruhi kinerja pekerja. Salah satu yang mempengaruhi kinerja adalah suhu ruangan yang harus sesuai dengan Nialai Ambang Batas (NAB) sebesar 18–28℃. Suhu ruang produksi pada toko roti Gembong Gedhe melebihi NAB yaitu sebesar 29,3℃. Oleh karena itu perlu di lakukan analisis pengaruh paparan temperature terhadap beban mental pekerja
Metode yang di lakukan dalam menyelesaikan permasalahan pada toko roti Gembong Gedhe yaitu dengan menggunakan metode NASA-TLX. Dengan harapan dapat analisis beban mental pekerja dari paparan panas dengan menggunakan software surfer 11. Berdasarkan hasil analisis data dengan uji Chie-square di dapatkan nilai p-value 0,0594 pada variabel KW, nilai p-value 0,997 pada vaiabel P, dan nilai p-value 0,997 pada variabel TU. Sehingga terdapat variabel Kebutuhan Waktu (KW),Performansi (P), dan Tingkat Usaha (TU) berpengaruh terhadap beban kerja mental.
Kata kunci: Beban Kerja Mental, Software Surfer 11, NASA-TLX
Dental health status assessment of TNI-AL bintara officers using DMFT index and Chief of Naval Staff Regulation: a descriptive study
Authors: Arifin Kanisa Mirena , Irmaleny Irmaleny , Sitam Suhardjo , Setiawan Krisnadi 
Published: January 2024

ABSTRACTIntroduction: Military personnel belong to a high-risk group for the development of various pathological conditions in the oral cavity. Based on research, the experience of dental caries in the army population of several other countries was relatively high. The purpose of this study was to describe the assessment of the dental health status of Bintara Officer (the NCO) the Indonesian National Military-Naval Force (TNI-AL) using caries experience index. Methods: The descriptive method was used with primary data collection through the caries experience index (DMF-T) examination and assessment of the dental health status of the TNI-AL. A purposive sampling technique with a total of 40 members with inclusion criteria, ranked Bintara Officer, 10 years of service, male or female, was used. Exclusion criteria were those serving outside the city or abroad and not signing an informed consent form. The data was collected and analyzed descriptively using Microsoft Excel. Results: DMF-T index value was 3.7, included in the Stakes I category, which had a maximum number of DMF of 10 teeth: 25.0% in the very low category, 17.5% in the low category, 27.5% in the moderate category, 17.5% in the high category, and 12.5% in the very high category. The dental health status of the TNI-AL were 95.0% in the Stakes I category, 2.5% in the Stakes II category, 2.5% in the Stakes III category, and there were no subjects in the Stakes IV category. Conclusion: Assessment of the dental health status of bintara officer Indonesian National Military-Naval Force using DMFT index value was in the moderate category, and based on Perkasal the majority was included in the Stakes I category.KEYWORDS : Caries, DMF-T index, dentistry, TNI-AL dental health status
Analysis of the completeness of specific nutritional interventions as an effort to prevent stunting: an observational study
Authors: Setianingsih Triseu , Hussain Nervana 
Published: January 2024

ABSTRACT Introduction: Handling stunting through nutritional interventions is classified into two categories: specific nutrition interventions and sensitive nutrition intervention. Specific nutrition interventions referring to causal factors directly related to nutrition, aimed at pregnant women and breastfeeding mothers, are the responsibility of the health sector, contributing 30%. The completeness of specific nutritional interventions for breastfeeding mothers according to standards are more challenging. The purpose of this study is to analyze several factors that influence the completeness of specific nutritional interventions in breastfeeding mothers to create prediction models. Methods: This was a quantitative study with a cross sectional design. The population was all breastfeeding mothers with a total of 193 nursing mothers. Samples of 128 people were taken using a simple random sampling technique. Data analysis using univariate analysis, bivariate analysis with Chi square analysis and Multivariate analysis with logistic regression analysis. Result: In bivariate analysis there were 8 influencing variables. The Mother’s education with p=0.006, Mother’s knowledge with p=0.001, Mother’s Attitudes with p=0.001, Mother’s Job with a p=0.001, Parity with p=0.001, Husband's Support with p=0.001, Health Workers’ Support with p=0.001, Village Officials’ Support with p=0.001. The most influential variable was the health workers’ support variable with OR=20.56. Through multivariate analysis, a predictive model of achieving completeness of specific nutritional interventions is produced so that it can be used as a preventive effort in overcoming these problems. Conclusion: The completeness of specific nutritional interventions for breastfeeding mothers has not been achieved according to the government's target, it is necessary to intervene on the factors that influence it which include mother’s knowledge, mother’s attitude, husband’s support, health workers’ support and village apparatus’ support.Keyword : Stunting, nutritional support, specific intervention
Improving the timeliness of college English teaching model based on multilevel fuzzy evaluation
Authors: Pang Bingliang , Li Zaimin , Liu Bing 
Published: January 2024

Abstract
In order to meet the changing educational needs, this paper collects the factors related to the teaching mode through the method of multilevel fuzzy evaluation and establishes a multilevel fuzzy evaluation system including the factors of teaching methods, textbook selection, learning resources and so on. To obtain quantitative satisfaction results, fuzzy numbers are employed to calculate the satisfaction evaluation of teaching programs. Establish a judgment matrix using triangular fuzzy numbers and hierarchical analysis to assign weights to different indicators. The evaluation results of each factor are synthesized to obtain the evaluation results for the timeliness of the English teaching method. The results show that although there is not much difference in the basic level of English between the experimental class and the control class, the experimental class, after using the method of this paper, has a measure of qualitative data higher than the standardized metric of 71.195, and the academic grade reaches a full score of 10. It is further verified that by using the method based on multilevel fuzzy evaluation, universities can optimize their teaching mode in a more targeted way to adapt to the increasingly changing educational environment.
Innovation and Practice of Public Security Police Training Curriculum and Education System in the Age of Information Technology with Police Professional Competence as the Core
Authors: Yang Zhiguo 
Published: January 2024

Abstract
This paper constructs an educational innovation system for training courses based on information technology with the core of police professional ability. Firstly, using the vector space model, each document of the training course knowledge point establishes the weight information. Then, using the triangular dissection algorithm, the police combat training virtual reality scene is constructed, achieving two modes of display: a three-dimensional view window and a two-dimensional planar map. Finally, through the discrete point topology relationship, the scene image becomes more realistic and clear during the process of realizing dynamic simulation. The results show that in the police training innovation system constructed in this paper in the professional knowledgeability test, the number of people who passed the score is more than 300. The special course training had a pass rate that exceeded 80%. The research of this paper is of great significance to the reasonable construction of the police’s business knowledge structure and vocational ability structure and to improve the overall combat effectiveness of public security organs.