bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diminazene aceturate, an ACE2 activator, ameliorates testicular injury in diet-induced obese mice
Authors: Yue Xiaofeng , Yin Rui , Wu Liling , Li Jinjin , Wang Jianwu , Yan Benhuang , Dai Lingyong , Shen Chongxing , Zhi Yi , Wan Ling , Yang Jigao , Li Weibing 
Published: January 2025

In brief
Obesity is a prevalent health concern globally, often associated with testicular damage that can lead to male infertility. This study investigates the improvement of obesity-induced testicular damage by ACE2 agonist diminazene aceturate (DIZE) and explores the role of the ACE2/Ang 1–7/MasR axis in this process.

Abstract
DIZE improved obesity and metabolic disturbances in diet-induced obesity (DIO) mice. An increase in sperm count and motility, along with improved morphology and increased male fertility, was observed after DIZE treatment. Both serum and intratesticular testosterone levels showed an increase. Moreover, ACE2/Ang 1–7/MasR protein levels in the testes were restored, which inhibited germ cells apoptosis, lipid accumulation and oxidative stress, and elevated testosterone synthesis-related proteins. However, the MasR antagonist A779 partially counteracted the improving effects of DIZE on metabolism and the testes of DIO mice. This study shows that DIZE treatment has protective effects against obesity-induced testicular injury by activating the ACE2/Ang 1–7/MasR axis.
Academic Achievement of Children With Neurofibromatosis Type 1
Authors: Hou Yang , Zong Xiaoli , Wu Xian , Liu Dan , Wolters Pamela L. , Janusz Jennifer , Walsh Karin S. , Morris Stephanie M. , Payne Jonathan M. , Pride Natalie , Garg Shruti , Robinson Louise , Stavinoha Peter L. 
Published: January 2025

BACKGROUND AND OBJECTIVES
Learning difficulties are frequently reported in children with neurofibromatosis type 1 (NF1), yet little is known about the extent and predictors of their academic functions across ages. We aimed to examine the developmental patterns of academic achievement in these children from childhood to adolescence and how these patterns differ across demographic and NF1-related disease factors.

METHODS
This cross-sectional study integrated data of 1512 children with NF1 (mean age, 11.2 years, SD, 3.62, range, 3–18, 46.5% female patients) from 8 institutions. Academic functioning was assessed with Woodcock-Johnson Tests of Achievement or the Wechsler Individual Achievement Test. Data were analyzed primarily using time-varying effect modeling.

RESULTS
Participants’ academic achievement was significantly lower than the normative means across ages, and the gap widened from middle childhood to midadolescence. Academic age trends varied across academic domains and demographic and disease factors. Male patients demonstrated larger deviations in math at midchildhood and in reading and writing between midchildhood and midadolescence. Children with lower parental education demonstrated larger deviations in math, reading, and writing between midchildhood and midadolescence. Children with familial NF1 demonstrated larger deviations in math at midchildhood and mid-to-late-adolescence, and in reading and writing between midchildhood and midadolescence.

CONCLUSIONS
Academic difficulties in children with NF1 emerge early and worsen with age. The findings also highlight the variability within this population across demographic and disease factors. The age-specific estimates of academic functions can serve as the first NF1-specific academic norms, providing useful insights for future research and practice.
Interaction effect of mobile gaming addiction and excessive sugar-sweetened beverage consumption on overweight and obesity among schoolchildren: Evidence from a large population-based study in Guangzhou, China
Authors: Jin Zhengge , Ge Wenxin , Bao Wenwen , Liang Jinghong , Zhang Yushan , Hu Lixin , Pu Yingqi , Liu Meiling , Chen Jiaqi , Yang Xiuzhi , Wu Zhuowen , Chen Yajun 
Published: January 2025

AbstractObjectiveTo explore the individual and interactive associations between mobile gaming addiction (MGA), excessive consumption of sugar-sweetened beverages (SSBs), and overweight/obesity among schoolchildren, and to investigate whether these interactions vary by gender or grade level.MethodsData were drawn from the Children's Growth Environment, Lifestyle, and Physical and Mental Health Development project (COHERENCE) conducted in Guangzhou, China, during the 2019/20 academic year. 418,197 children aged 6–12 years were included in the study. All participants were asked to complete an eligible questionnaire to provide details of their MGA over the past three months and SSBs consumption over the past week. Multiplicative and additive interaction models were performed to evaluate the interaction effects of MGA and excessive SSBs consumption on overweight/obesity, and variations by gender and grade level were also examined.ResultsExcessive SSBs consumption was identified as a risk factor for childhood overweight/obesity, but MGA was not. However, the combination of MGA and excessive SSBs consumption was associated with an increased risk of overweight/obesity. This multiplicative interaction was significantly stronger in girls than in boys, with no differences observed across grade levels. Additionally, the additive interaction effect between MGA and excessive SSBs consumption was present only in girls and children in the lower elementary grades.ConclusionsThis cross-sectional study found that the combination of MGA and excessive SSBs consumption is linked to an increased risk of childhood overweight/obesity, particularly in girls and children in lower elementary grades. These findings highlight the importance of addressing these factors together in targeted interventions.
Preliminary results from a community-based ayahuasca-assisted mental health program among a Yaqui Indigenous population in Sonora, Mexico
Authors: Giovannetti Cecile , Loizaga-Velder Anja , Campoy Gomez Ricardo , Ochoa Jaime Gloria Rachel , Castillo Valenzuela Teresa , Sanchez Guadalupe , Marcus Olivia , Agin-Liebes Gabrielle , Rush Brian 
Published: January 2025

AbstractBackgroundThe Yaqui Intercultural Medicine Clinic was established in 2020 to provide accessible, culturally-attuned treatment for substance use and mental health disorders among an Indigenous Yaqui community in Mexico. The treatment program integrates ayahuasca ceremonies and psychotherapeutic support within a community-based outpatient treatment service. This observational pilot study was conducted to evaluate the safety, short-term symptom improvement, and cultural implications of the clinic's program.MethodsData from 37 patients who were diagnosed with depression, anxiety, complicated grief, or substance use disorder were included in the analysis. Patients were included in the study if they participated in at least one ayahuasca session with psychotherapeutic support. Data were collected using the Mini International Neuropsychiatric Interview (MINI), Beck Depression Inventory (BDI-II), Beck Anxiety Inventory (BAI), Index for Complicated Grief (ICG), and the Post-Traumatic Stress Checklist for DSM-5 (PCL-5).ResultsPatients demonstrated marked reductions in scores of depression, anxiety, complicated grief, suicidality, and PTSD symptoms following ayahuasca ceremonies. After two ceremonies, mean BDI-II scores dropped from 15.7 to 5.1, mean BAI scores dropped from 16.6 to 6.3, and ICG scores reduced from 39.6 to 10.7. Among eight patients presenting suicide risk, seven cases resolved following a single ayahuasca ceremony. Safety assessment indicated that ayahuasca ceremonies were well-tolerated.ConclusionsPreliminary data suggest that ayahuasca ceremonies integrated within a culturally-attuned community-based mental health program show promise for rapidly reducing mental health symptoms among a small group of Yaqui patients. These findings support further research of community-based ayahuasca-assisted therapeutic programs for mental health treatment within Indigenous communities.
Kiedy urodziła się królowa Jadwiga?
Authors: Sroka Stanisław A. 
Published: January 2025

Autor powraca do wielokrotnie już omawianego w literaturze wątku, jakim jest data urodzin królowej Jadwigi Andegaweńskiej. Wychodząc z postanowień średniowiecznego prawa kanonicznego, wedle którego zaręczyny (tzw. matrimonium pro futuro) mogły mieć miejsce, gdy przyszli małżonkowie mieli ukończone 7 lat, zwraca uwagę, że układy zaręczynowe Jadwigi z Wilhelmem Habsburgiem zorganizowane w Hainburgu (1378), a potwierdzone w Zwoleniu (1380), nie były zgodne z tym prawem, albowiem Jadwiga nie miała ukończonych 7 lat, aby wyrazić na nie zgodę. Dopiero akt z 20 marca 1381 roku (wcześniej nieznany w literaturze) mówiący o zawarciu pomiędzy Wilhelmem a Jadwigą „matrimonialis contractus” został wystawiony po spełnieniu tego wymogu wieku. Dokument ten dowodzi jednoznacznie, że Jadwiga urodziła się w 1374 roku. Natomiast data dzienna urodzin królowej wciąż pozostaje w kręgu dyskusji.
Educación Emocional y Espiritual: un Desafío para la Escuela del Siglo XXI
Authors: Joleanes Escobar Yulis Rocio , Bellido Acuña Nelsis , Agudelo Giraldo Maria Alicia 
Published: January 2025

El presente estudio se enfoca en la importancia de impartir educación emocional y espiritual desde la primera infancia y destacar su incidencia en el desarrollo integral y la sana convivencia. Siendo la dimensión emocional y la dimensión espiritual parte esencial del ser humano, se encuentra que estas no se incorporan en el currículo, prestando especial interés al desarrollo cognitivo.
La investigación se realizó en una institución educativa de carácter público en la ciudad de Barranquilla. Se asumió desde un enfoque cualitativo, fundamentado en el paradigma hermenéutico y diseño etnográfico. La población estuvo constituida por 21 estudiantes de grado transición y la muestra no probabilística la constituyeron nueve niños. La información se obtuvo por medio de la Escala de Valoración Cualitativa del Desarrollo Infantil, ficha de caracterización socio familiar, registros del observador del estudiante, observación participante, entrevista semiestructurada, videos, diario de campo y talleres. Se encontró que, al implementar con los niños prácticas para el desarrollo de la inteligencia emocional y el cultivo de la inteligencia espiritual, se presentó mayor autocontrol, actitudes positivas hacia sí mismo, mejora en procesos comunicativos, interés por cooperar y compartir, mayor capacidad de concentración y escucha y mayor capacidad para comprender los sentimientos de sus compañeritos.
El teatro como estrategia didáctica para abordar las violencias en contextos escolares
Authors: Rodríguez Mogollón Michael , Gómez Merchán Eric 
Published: January 2025

La violencia tiene múltiples dimensiones y cobra vigencia cuando en los espacios educativos repercuten sus efectos y se presentan manifestaciones de esa realidad conflictiva, por lo que abordar la pedagogía desde una perspectiva liberadora es apremiante en tanto la necesidad de resignificar la manera de estar juntos a través del conocimiento crítico, desarrollo del pensamiento creativo y el favorecimiento de la reflexión del individuo. Conocer e interpretar el impacto de la estrategia didáctica del teatro permite a los sujetos discutir su realidad social, y luego realizar una lectura del mundo, para luego intervenirlo hacia situaciones más favorables. El presente trabajo analiza cualitativamente esta indagación, para la cual se utilizó un diseño de estudio de caso, en el que los resultados indican que la implementación de la estrategia didáctica hace manifiestas las lecturas sobre las violencias y se vuelven explícitas esas realidades conflictivas por parte de los estudiantes, que luego son confrontadas por medio de la práctica teatral para la resolución de conflictos y en la generación de espacios de convivencia por medio de la creatividad. Se postula que el teatro promueve la identificación, el abordaje, la resolución de conflictos y la generación de ambientes de convivencia entre los estudiantes.
Pájaro amargo: relaciones kafkianas y sentimentalidades en la poesía de José Ramón Mercado
Authors: Bolaño Sandoval Adalberto 
Published: January 2025

Este artículo compara el poemario Pájaro amargo de Mercado como una poesía de la experiencia familiar, con algunos rasgos de la literatura de Franz Kafka, tanto en lo temático como en el manejo contradictorio del equilibrio, la rabia, el dolor y la pasión; por ello, el texto constituye una mirada que va de lo íntimo a lo público, en la que aparecen las sentimentalidades de manera dramática o trágica, encauzadas por lo infausto y lo patriarcal del padre, como consecuencias de una “literatura menor”. El poemario se enmarca bajo un discurso lírico consistente, macerado, revelando un más allá artístico, que universaliza el lamento, que retrata la memoria conmovida y busca no “derramar una lágrima frente al recuerdo”. El análisis parte de Paul Ricoeur y sus planteamientos sobre la culpa, la conciencia juzgada y la reconciliación, y de los aportes de Walter Benjamin, Gilles Deleuze y Félix Guattari y Mónica Cragnolini, como lectores de la obra kafkiana, en especial desde las metáforas animalescas entre personajes y seres.
conocimiento de sí mismo y de los otros.
Rotifer Brachionus rotundiformis enriched with taurine for survival and growth of larval milkfish Chanos chanos
Authors: Aimma Muhammad Ariful , Dedi Jusadi  , Suprayudi Muhammad Agus , Alimuddin Alimuddin , Adiasmara Giri I Nyoman , Shofa Adestia Talita 
Published: January 2025

This research evaluated the effect of taurine-enriched rotifers on the survival and growth of milkfish larvae. Twenty-five fertilized milkfish eggs were placed in a 250 L cylindrical fiber tank. This study used a completely randomized design with four treatments and five replications. Three days old larvae were given rotifers enriched with taurine at 0, 25, 50, or 75 mg/L. Larvae were cultured until they were 18 days old. The results showed that the taurine content in rotifers was higher in rotifer at 50 mg/L treatment, then decreased at the 75 mg/L treatment. Taurine content in the milkfish larvae aligned with taurine levels in rotifers. Furthermore, the taurine content in rotifers affected milkfish larvae' survival and body length. The highest larval survival and growth was obtained in the 50 mg/L taurine treatment. Thus, it can be concluded that taurine at 50 mg/L is the optimal rotifer enrichment dose for milkfish larvae.

Keywords: growth, milkfish larvae, notochord, survival rate, taurine

ABSTRAK

Penelitian ini dilakukan untuk mengevaluasi pengaruh pemberian rotifera yang diperkaya taurin terhadap kelangsungan hidup dan pertumbuhan larva ikan bandeng. Dua puluh lima butir telur ikan bandeng yang telah dibuahi ditempatkan pada tangki fiber berbentuk silinder berukuran 250 L. Penelitian ini menggunakan rancangan acak lengkap dengan empat perlakuan dan lima ulangan. Larva berumur tiga hari setelah menetas diberi rotifer yang diperkaya taurin dengan dosis 0, 25, 50, atau 75 mg/L. Larva dipelihara hingga berumur 18 hari. Hasil penelitian menunjukkan bahwa kandungan taurin pada rotifer tertinggi diperoleh pada perlakuan rotifer 50 mg/L, kemudian menurun pada perlakuan rotifer 75 mg/L. Kandungan taurin pada larva ikan bandeng sebanding dengan kandungan taurin pada rotifer. Kandungan taurin pada rotifer berpengaruh nyata terhadap kelangsungan hidup dan panjang tubuh larva ikan bandeng. Kelangsungan hidup dan pertumbuhan larva tertinggi diperoleh pada perlakuan dosis 50 mg/L. Dari hasil penelitian dapat disimpulkan bahwa pemberian taurin 50 mg/L pada pengayaan rotifer merupakan dosis yang optimal untuk diberikan pada larva ikan bandeng.

Kata Kunci: kelangsungan hidup, larva bandeng, notochord, pertumbuhan, taurin
Utilization of chicken manure enriched with Lemna liquid organic fertilizer Lemna minor on cell density of Chlorella sp.
Authors: Rosyadi Rosyadi , Agusnimar Agusnimar , Khairul Hadi  
Published: January 2025

One of the organic fertilizers that has the potential to be used to culture Chlorella sp. is chicken manure. However, to increase the content of nutrients in chicken manure, it must be enriched with liquid organic fertilizer (POC) in different doses. The purpose of this study was to determine the optimal dose of chicken manure enrichment using Lemna POC on the cell density of Chlorella sp. This study used a complete randomized design (CRD) with 5 treatments of 3 replicates, namely P0 giving 3 g/L chicken manure (control), P1 = 3 g/L chicken manure enriched with 4% Lemna POC, P2 = 3 g/L chicken manure enriched with 5% Lemna POC, P3 = 3 g/L chicken manure enriched with 6% Lemna POC, and P4 = 3 g/L chicken manure enriched with 7% Lemna POC. The results obtained the highest cell density of Chlorella sp. in the P3 treatment of 516.67 ± 6.29 ×104 cells/mL, a specific growth rate of 0.142 cells/mL/day, and a biomass weight of 0.39 g/L. From the results of the study, it can be concluded that the optimal dose of chicken manure enrichment to increase the cell density of Chlorella sp. is 6% Lemna POC in P3 treatment.

Keyword: chicken manure, Lemna POC, Chlorella sp., cell density

ABSTRAK

Salah satu pupuk organik yang memiliki potensi dimanfaatkan untuk kultur Chlorella sp. adalah kotoran ayam. Namun untuk meningkatkan kandungan unsur hara pada kotoran ayam maka harus diperkaya dengan pupuk organik cair (POC) Lemna dengan dosis berbeda. Tujuan dari penelitian ini untuk mengetahui dosis pengayaan kotoran ayam yang optimal menggunakan POC Lemna terhadap kepadatan sel Chlorella sp. Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan 5 perlakuan 3 ulangan, yaitu P0 pemberian 3 g/L kotoran ayam (kontrol), P1 = 3 g/L kotoran ayam diperkaya 4% POC Lemna, P2 = 3 g/L kotoran ayam diperkaya 5% POC Lemna, P3 = 3 g/L kotoran ayam diperkaya 6% POC Lemna, dan P4 = 3 g/L kotoran ayam diperkaya 7% POC Lemna. Hasil penelitian diperoleh kepadatan sel Chlorella sp. tertinggi pada perlakuan P3 sebanyak 516,67 ± 6,29 ×104 sel/mL, laju pertumbuhan spesifik sebesar 0,142 sel/mL/hari dan berat biomassa sebesar 0,39 g/L. Dari hasil penelitian dapat disimpulkan bahwa dosis pengayaan kotoran ayam yang optimal untuk meningkatkan kepadatan sel Chlorella sp. adalah 6% POC Lemna pada perlakuan P3.

Kata kunci: kotoran ayam, POC Lemna, Chlorella sp., kepadatan sel
Evaluation of Vitamin D Supplementation in Critically Ill Patients - A Systematic Review of the Last 5 Years
Authors: Wang Shan , Ren Ruodi , Wang Kunkun , Leo Christopher , Li Mengyan , Chow Allison , Yang Andrew , Lu Yun 
Published: January 2025

Vitamin D deficiency was found to be associated with increased risks of infection, morbidity, and mortality in critically ill patients. However, current critical care guidelines do not recommend routine vitamin D supplementation. We conducted a literature search using Medline, Embase, Web of Science and Cochrane databases for randomized controlled trials published in the past five years on vitamin D supplementation in ICU patients. We analyzed data from 21 studies, reviewing dosing strategies, administration routes, baseline vitamin D levels, and clinical outcomes such as biomarker changes, mechanical ventilation duration, hospital length of stay, and mortality. Our results suggest that vitamin D supplementation may be safe and potentially beneficial in reducing ICU length of stay and time on mechanical ventilation. However, the impact on overall mortality remains uncertain. Our findings emphasize the need for individualized clinical decision-making regarding vitamin D supplementation in critically ill patients, considering baseline vitamin D levels, patient characteristics, severity of illness, and administration methods.
Unprecedented heat threatened 1 in 10 vertebrate species in 2023
Authors: Merow Cory , Serra-Diaz Josep , Carlson Ben , Maitner Brian , Pinilla-Buitrago Gonzalo , Trisos Christopher , Wilson Adam , Pigot Alex , Urban Mark 
Published: January 2025

Abstract

2023 was the hottest year in recorded history at the time of its recording1 and warmer than any in the past 125,000 years2. Although the effects of this unprecedented year on human health, agriculture, and economies have been documented3, we know much less about its effects on global biodiversity, especially in poorly monitored regions. Here, we demonstrate a rapid climate bioassessment pipeline to pinpoint when and where species have recently been exposed to extreme weather. Applying this approach to > 33,000 terrestrial vertebrate species, we demonstrate that 2023 posed unprecedented levels of risk to biodiversity, with half of all species exposed to extreme temperatures somewhere in their geographic range and 1 in 10 exposed across > 25% of their range. We show that exposure to extreme weather has increased rapidly over the last decade and that many species now exist dangerously close to their historical niche limits. Consequently, although the global mean annual temperature in 2023 was only 0.2oC warmer than the previous warmest year on record in 2016, species exposure doubled. Our 2023 vertebrate assessment provides a prototype for a highly flexible pipeline that can be extended to accommodate any pertinent weather data collected in real-time and can be customized for regional, taxonomic, or conservation-specific needs. Our pipeline can be used to direct management resources to those ecosystems and species, particularly in poorly monitored regions, that are at risk of unnoticed collapse, decline, or extinction following exposure to unprecedented conditions.
Dynamic evaluation of landslide susceptibility in a large-scale region based on time-series InSAR and multi-temporal cataloguing: a case study in Heifangtai, Gansu province
Authors: Ling Qing , Li Weizhi , qu jiebo , Guo Qi , Ren Junguang , Yang Chenjian , Kang Ronghua 
Published: January 2025

Abstract

Landslide disasters are common in the mountainous regions of western China, making accurate classification of landslide hazard risk levels essential for effective geological disaster management. Data-driven models have achieved notable advancements in landslide susceptibility evaluation. However, they still encounter challenges such as a lack of dynamic feature data and an over-reliance on sample quality, which limits their effectiveness for large-scales. To address these issues, this paper introduces an integrated evaluation approach that combines time-series InSAR deformation data with data-driven models. This method initially incorporated time-series InSAR deformation monitoring data as dynamic factors, which were filtered through multivariate covariance analysis to construct a dynamic landslide susceptibility evaluation system. Additionally, only landslide samples were adopted to conduct large-scale landslide susceptibility analysis. Various machine learning algorithms, based on landslide and non-landslide samples, were also applied for model comparison. Building upon this foundation, the evaluation of landslide susceptibility was performed by integrating InSAR deformation data with multi-temporal cataloging. The Heifangtai region in Gansu Province was chosen as a case study. The results indicate that the maximum entropy (Maxent) model achieved the highest accuracy for large-scale susceptibility assessments. Incorporating time-series InSAR deformation into the dynamic landslide susceptibility model improved accuracy by about 0.36%, compared to models without this data. Additionally, the proportion of landslides identified in high and very high susceptibility zones increased by 4.29%. By using eight years of landslide catalog data as positive samples, the presented model achieved an accuracy of 99.26%, demonstrating that long-term, high-quality positive samples improve the precision and reliability of regional predictions. This study advances large-scale landslide risk assessment by integrating a dynamic evaluation system that accounts for data across multiple time periods.