bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Influence of Dietary Fiber Intake and Ovarian Hormones on Body Mass Index Trajectories in Midlife Women: The Study of Women's Health Across the Nation
Authors: Luo Jing , Lin Song 
Published: September 2023

Abstract

Background
It is known that dietary fiber intake was inversely associated with risk of weight gain, while the association between dietary fiber intake and body mass index (BMI) trajectories over time is unclear. This study aimed to determine whether dietary fiber intake is associated with lower BMI trajectories and whether ovarian hormones would influence BMI trajectories in midlife women.
Methods
Participants were 2,706 multiracial/ethnic midlife women enrolled in a multi-site longitudinal menopause and aging study, Study of Women’s Health Across the Nation. Dietary intake was estimated using food frequency questionnaire with 103 food item at baseline. BMI and ovarian hormones were measured approximately annually from 1997 to 2008. Group-based trajectory modelling identified the trajectories of BMI and associations with time-varying ovarian hormones. The effect of dietary fiber intake (g/1000kcal·d) on BMI trajectories was examined using multinomial logistic regression.
Results
Participants had four distinct BMI trajectories: low BMI trajectory (30.4%), medium BMI trajectory (36.2%), high BMI BMI trajectory (22.9%), and very high BMI trajectory (10.5%). Each unit increase in dietary fiber intake (g/1000kcal·d) was less likely to be medium, high and very high BMI trajectories than low BMI trajectory. Compared to low BMI trajectory, daily dietary fiber intake 8-9g/1000kcal is the minimum requirement for the prevention of medium, high, and very high BMI trajectories. Women with dietary fiber intake exceeded 15g/1000kcal or 16g/1000cal per day have the lowest risk of medium and high BMI trajectories than low BMI trajectory, respectively. Of the time-varying covariates considered, higher total family income, drinking alcohol, higher quality of life, and serum estradiol, follicle-stimulating hormone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, was associated with a decrease BMI in almost all trajectories, while a positive relationship between testosterone and BMI was presented across all trajectory groups.
Conclusions
Higher fiber intake, especially 15–16 g/1000cal per day, was associated with lower BMI trajectories in midlife women. Health care providers need to evaluated women’s dietary intake, family economics, lifestyle, and ovarian hormones during midlife to monitor changes in these and BMI.
Machine-learning potentials for nanoscale simulations of deformation and fracture: example of TiB2 ceramic
Authors: Lin Shuyao , Casillas-Trujillo Luis , Tasnadi Ferenc , Hultman Lars , Mayrhofer Paul H. , Sangiovanni Davide , Koutná Nikola 
Published: September 2023

Abstract
Machine-learning interatomic potentials (MLIPs) offer a powerful avenue for simulations beyond length and timescales of ab initio methods. Their development for investigation of mechanical properties and fracture, however, is far from trivial since extended defects---governing plasticity and crack nucleation in most materials---are too large to be included in the training set. Using TiB2 as a model ceramic material, we propose a strategy for fitting MLIPs suitable to simulate mechanical response of monocrystals until fracture. Our MLIP accurately reproduces ab initio stresses and failure mechanisms during room-temperature uniaxial tensile deformation of TiB2 at the atomic scale (≈103 atoms). More realistic tensile tests (low strain rate, Poisson's contraction) at the nanoscale (≈104--106 atoms) require MLIP up-fitting, i.e. learning from additional ab initio configurations. Consequently, we elucidate trends in theoretical strength, toughness, and crack initiation patterns under different loading directions. To identify useful environments for further up-fitting, i.e., making the MLIP applicable to a wider spectrum of simulations, we assess transferability to other deformation conditions and phases not explicitly trained on.
Assembly of tight junction belts by surface condensation and actin elongation
Authors: Honigmann Alf , Sun Daxiao , Zhao Xueping , Wiegand Tina , Bartolucci Giacomo , Martin-Lemaitre Cecilie , Grill Stephan , Hyman Anthony , Weber Christoph 
Published: September 2023

Abstract
Tight junctions play an essential role in sealing tissues, by forming belts of adhesion strands around cellular perimeters. The formation of a tight junction occurs into two steps, initiation at cell-cell contacts, and elongation around the perimeter. Recent work has shown that nucleation is governed by condensation of scaffold proteins. However, the mechanisms by which condensates are spatially controlled to initiate at cell-cell contacts and elongate around cell perimeters remain unknown. Here, we combined cell biology, molecular reconstitution and thermodynamic modelling to show that belt formation is driven by a surface phase transition coupled to actin polymerization. Adhesion receptor oligomerization provides the signal for local surface condensation of ZO proteins. Surface condensates directly facilitate actin polymerization and filament bundling, which drives elongation of receptor-ZO-actin condensates into a junctional belt. We conclude that surface phase transitions provide a robust mechanism to locally control the position and shape of protein condensates.
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Authors: Javorniczky Nora Rebeka , Grishina Olga , Hund Inga , Pantic Milena , Pfeifer Dietmar , Schmoor Claudia , Thomas Johanna , Duyster Justus , Becker Heiko , Lübbert Michael 
Published: September 2023

Abstract
Elderly patients with AML ineligible for induction have dismal prognosis; hence disease stabilization is a primary treatment goal. This case of a 74-year-old patient with secondary AML receiving the combination of decitabine and ATRA (within the DECIDER trial, NCT00867672) demonstrates an above-average survival. The therapy administered over 52 cycles led to complete molecular and hematological remission and resulted in 5.3 years overall survival. Clonal evolution of the leukemic clone could be demonstrated using DNA sequencing methods. According to the literature this case constitutes the longest continued HMA exposure in an elderly AML patient ineligible for standard chemotherapy.
Malaria Parasite Classification from RBC Smears Using Lightweight Parallel Depthwise Separable CNN and Ridge Regression ELM by Integrating SHAP Techniques
Authors: Ahamed Md. Faysal , Nahiduzzaman Md. , Ayari Mohamed Arselene , Khandakar Amit , Islam S. M. Riazul 
Published: September 2023

Abstract
Malaria is a significant health concern worldwide, and early detection and accurate classification are essential for better treatment. This study proposes a new method that combines a lightweight parallel depth-wise separable convolutional neural network (LPDCNN) with a hybrid ridge regression extreme learning machine (RELM) to classify images of infected and uninfected patients' red blood cells (RBCs). We include a hybrid pre-processing step that uses contrast-limited adaptive histogram equalization (CLAHE) and Dilation operation to enhance image quality, reduce cell noise, and improve visual acuity. The LPDCNN extracts discriminative features efficiently with only 0.36 million parameters and 8 layers, minimizing computational complexity. The hybrid RELM model improves classification performance and replaces the traditional pseudoinverse of the ELM approach. Rigorous five-fold cross-validation (CV) for binary class classifications shows that the framework has impressive average precision, recall, f1, accuracy, and AUC scores of 99.86±0.08%, 99.88±0.084%, 99.84±0.089%, 99.85±0.071%, and 99.96±0.037%, respectively, surpassing state-of-the-art (SOTA) models. The proposed framework is exceptionally efficient, with an average training and testing time of 0.1376 and 0.00255 seconds, respectively. Additionally, the framework is integrated SHAP (Shapley Additive Explanations) to enhance interpretability, providing valuable insights into decision-making and instilling confidence in malaria diagnosis for real-world applications. This comprehensive approach holds promise in improving malaria diagnosis and patient outcomes worldwide.
Prognostic analysis of atrial fibrillation patients with acute cerebral infarction: a retrospective study of 330 cases over a 10-year period
Authors: Wang Hai-Xia , Zhang Nan , Wang Guo-Qiang , Huang Yong-Hua 
Published: September 2023

Abstract
Background:
The neurologic outcome of atrial fibrillation (AF) patients with acute ischemic stroke (AIS) is usually worse than those without AF. The aim of our study was to evaluate prognostic factors in AF-AIS.
Methods
We retrospectively collected information about AF-AIS patients admitted to our department from Jan. 2013 and Aug. 2023. According to the modified Rankin Scale (mRS) score at discharge, patients were divided into two groups: group A with favorable outcomes (mRS ≤ 2,) and group B with poor outcomes (mRS > 2).
Results
A total of 330 AF-AIS patients met the inclusion criteria, including 95 in group A and 235 in group B. The large-, medium- and small-infarct sizes were 45.5%, 31.5% and 23.0%, respectively. Intravenous alteplase thrombolysis (IV-rtPA) was prescribed to 69 patients. Parenchymal hemorrhage (PH) was present in 53 (16.1%) patients. The incidence of PH for patients with IV-rtPA was 34.8% (24/69), and 17.9% (45/251) for no-IV-rtPA patients. In univariate analysis, older age, higher NIHSS score and glucose, lower level of triglyceride, lager infarct size and PH were all associated with a poor outcome. No difference was found between the good and poor outcomes with IV-rtPA (18.9% vs. 21.7%, p = 0.578). In multivariate analysis, age (OR 1.059, 95% CI 1.024–1.094, p = 0.001), NIHSS score (OR 1.305, 95% CI 1.210–1.407, p < 0.001), infarct size (OR 2.485, 95% CI 1.018–6.062, p = 0.045), glucose (OR 1.994, 95% CI 1.011–3.933, p = 0.046) and PH (OR 4.130, 95% CI 1.303–13.092, p = 0.016) were independently associated with poor outcome. And, large infarct size (OR 3.786, 95% CI 1.912–7.459, p < 0.001), IV-rtPA (OR 4.904, 95% CI 2.452–9.808, p < 0.001), lower baseline level of triglyceride (OR 3.797, 95% CI 1.636–8.817, p = 0.002) and diabetes mellitus (OR 2.973, 95% CI 1.477–5.983, p = 0.002) were significantly associated with the development of PH.
Conclusion
The majority of AF-AIS patients had a poor outcome, which was independently associated with age, NIHSS score, infarct size, glucose and PH. IV-rtPA was related to an increased risk of PH and failed to improve overall short-term outcomes, especially for those with a large infarct size, a lower level of baseline triglyceride and a history of diabetes mellitus.
Evolution of protein domains and protein domain combinations provides insights into the origin and diversification of land plants
Authors: Xue Jia-Yu , Yang Cheng-Ao , Hu Shuai-Ya , Fan Hai-Yun , Shao Zhu-Qing , Dong Shanshan , Liu Yang , de Peer Yves Van 
Published: September 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Lebesgue spaces with variable exponent: some applications to the Navier-Stokes equations
Authors: Chamorro Diego , Vergara-Hermosilla Gaston 
Published: September 2023

Abstract
In this article we study some problems related to the incompressible 3D Navier-Stokes equations from the point of view of Lebesgue spaces of variable exponent. These functional spaces present some particularities that make them quite different from the usual Lebesgue spaces: indeed, some of the most classical tools in analysis are not available in this framework. We will give here some ideas to overcome some of the difficulties that arise in this context in order to obtain different results related to the existence of mild solutions for this evolution problem.
Glycerol tributylate promoted the liver lipid metabolism by cultivating the intestinal flora of Grass carp
Authors: Ji Yan , Hu Bing , Wang Youzhen , Dong Guifang , Zhang Chi , Yu Denghang 
Published: September 2023

Abstract
To investigate the effects of glycerol tributyrin (TB) on the regulation of liver lipid metabolism by intestinal flora of grass carp. The compound feed with soybean oil 2.8% + fish oil 1.8%, soybean oil 6.3% + fish oil 1.8% and soybean oil 6.2% + fish oil 1.8% + TB 0.1% were added to the basal diet as a fat source and fed to the basal (Control) group, high lipid (HL) group, and tributyrin (TB) group, respectively. After 12 weeks, 16S rRNA sequencing was conducted on the intestinal flora of grass carp. The results found that the grass carp intestinal microflora in the TB group was more abundant and complex than in the HL group, with a number of novel and unique microflora. To summarize, a high-fat diet can induce the development of nutritional fatty liver in the host by affecting the composition of the intestinal microbial community, and TB can exert its lipid-lowering effects under high-fat diet conditions by affecting the composition of the intestinal microbial community.
Seabed Benchmark System in Aira Caldera
Authors: Tsutsui Tomoki , Miki Daisuke , Iguchi Masato 
Published: September 2023

Abstract
This paper describes the performance of a seabed benchmark system for measuring ground deformation associated with underwater volcanism. The system is installed in the center of the Aira Caldera, Japan, on the caldera floor 30 meters below the sea surface. This is the first attempt to directly measure the expected ground deformation within a flooded caldera in Japan. The system consists of an anchor, a universal joint, a rigid steel pillar, a float and a deck. A global navigation satellite system antenna array, consisting of a master antenna and auxiliary antennas, is installed at the top of the freely tilting pillar to monitor the position of the benchmark at the caldera bottom. A post-processing procedure is used to reduce the tilt of the master antenna based on measurements made by the auxiliary antennas. The system was installed in March, 2023, and has since been operating successfully with an acceptable measurement standard deviation.
Computational Fluid Dynamics Of Bladder Voiding Using 3D Dynamic MRI: A Pilot Study
Authors: Shahid Labib , Gonzalez-Pereira Juan Pablo , Johnson Cody , Bushman Wade , Roldán-Alzate Alejandro 
Published: September 2023

Abstract
Over the last couple of decades, image-based computational fluid dynamics (CFD) has revolutionized cardiovascular research by uncovering hidden features of wall strain, impact of vortices, and its use in treatment planning, as examples, that were simply not evident in the gold-standard catheterization studies done previously. In the work presented here, we have applied magnetic resonance imaging (MRI)-based CFD to study bladder voiding and to demonstrate the feasibility and potential of this approach. We used 3D dynamic MRI to image the bladder and urethra during voiding. A surface mesh processing tool was developed to process the bladder wall prior to executing a wall-motion driven CFD simulation of the bladder and urethra. The obtained flow rate and pressure were used to calculate urodynamic nomograms which are currently used in the clinincal setting to assess bladder voiding dysfunction. These nomograms concluded that our healthy volunteer has an unobstructed bladder and normal contractility. We calculated the work done to void the bladder and propose this as an additional quantitative metric to comprehensively assess bladder function. Further, we discuss the areas that would improve this relatively new methodology of image-based CFD in urodynamics.
Generation Whatsup: Inter-Brain Synchrony during Face-to-Face and Texting Communication
Authors: Schwartz Linoy , Hayut Olga , Endevelt-Shapira Yaara , Feldman Ruth 
Published: September 2023

Abstract
Texting has become one of the most prevalent ways to interact socially, particularly among youth; however, the effects of text messaging on social brain functioning are unknown. Guided by the biobehavioral synchrony frame, this pre-registered study utilized hyperscanning EEG to evaluate interbrain synchrony during face-to-face versus texting interactions. Participants included 65 mother-adolescent (M = 12.28 years, range 10–15) dyads, observed during face-to-face conversation compared to texting from different rooms. The results indicate that both face-to-face and texting communication elicit significant neural synchrony compared to surrogate data, demonstrating for the first time brain-to-brain synchrony during texting. Direct comparison between the two interactions pinpointed 8 fronto-temporal interbrain links that are unique to the face-to-face interaction, suggesting that partners jointly create a fronto-temporal network during live social exchanges. Improvement in the partners' right-frontal-right-frontal connectivity from texting to live interactions correlated with greater behavioral synchrony, linking this well-researched neural connection with greater specificity of face-to-face communication. The findings suggest that while technology-based communication allows humans to synchronize from afar, face-to-face interactions remain the superior mode of communication for interpersonal connection. We conclude by discussing the potential benefits and drawbacks of the pervasive use of texting by youth.
The association of serum dimethylglycine with the risk of cancer
Authors: Zhang Heyang , Wei Yaping , Xie Hailun , Liu Xiaoyue , Liu Lishun , Song Yun , Chen Ping , Wang Xiaobin , Lin Shiqi , Liu Tong , Ge Yizhong , Ruan Guotian , Tang Meng , Song Mengmeng , Shi Han-Ping 
Published: September 2023

Abstract
Background & aims:
Few studies have explored the effect of serum dimethylglycine on cancer risk. This study aimed to investigate the relationship between serum dimethylglycine and the risk of new cancers.
Methods
We conducted a nested case-control study using data from the "H-type Hypertensive Stroke Prevention and Control Project" on adults with hypertension from the Rongcheng cohort, including 1510 cancer cases and 1510 matched controls. Univariate and multivariate logistic regression was used to study the relationship between serum dimethylglycine and cancer risk.
Results
Participants were 56% male with a mean age of 69.45 ± 7.73 years. A multivariate-adjusted restricted cubic spline plot showed that serum dimethylglycine concentrations were positively and non-linearly associated with cancer risk. Multivariate logistic regression results showed that with a cut-off value of 1.05ug/mL, serum dimethylglycine > 1.05ug/mL had a non-linear, positive correlation with the risk of cancer (P = 0.002). Stratified analysis showed that high levels of dimethylglycine and age < 65 years (vs. age ≥ 65 years), males (vs. females), BMI < 24 (vs. BMI ≥ 24kg/m2), no antihypertensive medication use (vs. antihypertensive medication use), no hypoglycemic medication use (vs. hypoglycemic medication use), former smokers (vs. non-smokers), former drinkers (vs. non-drinkers), fruit and vegetable intake (< 0.5 kg/week vs. >0.5 kg/week), or no family history of cancer (vs. family history of cancer) were associated with increased cancer risk. There was a significant interaction between dimethylglycine and hypoglycemic drug use, with high concentrations of dimethylglycine associated with higher cancer risk than low concentrations in patients not taking hypoglycemic drugs (P = 0.035 for interaction).
Conclusions
We found that elevated serum dimethylglycine levels were positively associated with cancer risk in patients with hypertension. Our findings may contribute to future cancer prevention and diagnosis.
The effect of an electronic checklist on the quality of patient handoff process from the operating room to intensive care unit
Authors: Latifinasab Raha , Sheini-Jaberi Parisa , Asadizaker Marzieh , Sharhani Asaad 
Published: September 2023

Abstract
Introduction: Handoffs is one of the main processes in health care providers. Paper checklists are commonly used to handoff from operating room to intensive care units. However, paper checklists do not guarantee accurate and complete exchange of information during handoff. The present study aimed to investigate the effectiveness of electronic handoff tool on improve quality of transfer of care from OR to ICU.
Methods: The research community of this interventional quasi experimetal study included all situations of patient handoff from the OR to ICU of Golestan Hospital, Ahvaz. Handoff situation were randomly distributed in two control and intervention groups. The participants completed the checklists related to 84 transfer situations of patient care from the operating room to the ICU, including 42 handoff situations using electronic checklists as an intervention and 42 handoff situations using conventional paper checklists as a control group. Quality of care handoff was assessed using the Handoover Evaluation Scale (HES). Data analysis was performed using SPSS software version 22.
Results: HES score in paper checklist group was 35.38 ± 3.66, in electronic checklist group was 38.10 ± 3.61. Handoff scores in the two dimensions of quality of information and efficiency in the group using the electronic checklist were statistically significantly higher than the paper checklist group (P= 0.004).
Conclusion: It seams implementation and adherence of electronic handoff tool, developmented in this study, dramatically increased the quality of patient handoff process from OR to ICU.
On the restriction of a right process outside a negligible set
Authors: Li Liping , Michael Röckner 
Published: September 2023

Abstract
The objective of this paper is to examine the restriction of a right process on a Radon topological space, excluding a negligible set, and investigate whether the restricted object can induce a Markov process with desirable properties. We address this question in three aspects: the induced process necessitates only right continuity; it is a right process, and the semi-Dirichlet form of the induced process is quasi-regular. The main findings characterize the negligible set that meets the requirements within a universally measurable framework. These characterizations can be employed to generate instances of Markov processes that are non-right or (semi-)Dirichlet forms that are non-quasi-regular. Specifically, we will construct an example of a non-tight, strong Feller, symmetric right process on a non-Lusin Radon topological space, whose Dirichlet form is not quasi-regular.