bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice
Authors: Rives Clémence , Martin Céline Marie Pauline , Evariste Lauris , Polizzi Arnaud , Huillet Marine , Lasserre Frédéric , Alquier‐Bacquie Valérie , Perrier Prunelle , Gomez Jelskey , Lippi Yannick , Naylies Claire , Levade Thierry , Sabourdy Frédérique , Remignon Hervé , Fafournoux Pierre , Chassaing Benoit , Loiseau Nicolas , Guillou Hervé , Ellero‐Simatos Sandrine , Gamet‐Payrastre Laurence , Fougerat Anne 
Published: October 2023

ScopeNon‐alcoholic fatty liver disease (NAFLD) is a sexually dimorphic disease influenced by dietary factors. Here, the metabolic and hepatic effects of dietary amino acid (AA) source is assessed in Western diet (WD)‐induced NAFLD in male and female mice.Methods and resultsThe AA source is either casein or a free AA mixture mimicking the composition of casein. As expected, males fed a casein‐based WD display glucose intolerance, fasting hyperglycemia, and insulin‐resistance and develop NAFLD associated with changes in hepatic gene expression and microbiota dysbiosis. In contrast, males fed the AA‐based WD show no steatosis, a similar gene expression profile as males fed a control diet, and a distinct microbiota composition compared to males fed a casein‐based WD. Females are protected against WD‐induced liver damage, hepatic gene expression, and gut microbiota changes regardless of the AA source.ConclusionsFree dietary AA intake prevents the unhealthy metabolic outcomes of a WD preferentially in male mice.
Development and construction of an open‐platform, open‐source low‐cost portable uroflowmeter: The OpenFlow device
Authors: Gallo Germano Adelino , Cabral Dias Filho Aderivaldo , Cruz Pedro Rincon Cintra da , Moraes Clayton Franco 
Published: October 2023

AbstractBackgroundUroflowmetry is useful to screen for and manage many voiding disorders. Home‐based uroflowmetry might better represent the patient's true voiding pattern and be more widely adopted if an accurate low‐cost portable device was available.ObjectiveDevelopment and initial evaluation of an open‐platform, open‐source low‐cost portable uroflowmeter.Materials and MethodsWe designed and built an uroflowmeter comprising of a load cell and digital memory card unit connected to a programmable microcontroller board mounted upon a 3D printed frame. It generated date‐stamped tables which were processed and plotted. Twenty urologists were recruited to assess the device. Each participant received the equipment that was returned, along with a bladder diary, after at least 24 consecutive hours of homemade uroflowmetry recording. Additionally, were assessed with the International Prostatic Symptom Score (I‐PSS) and Peeling diagram, whereas the device's ease of use, robustness, and portability were evaluated with a Likert‐type questionnaire. Two experienced urodynamicists independently evaluated the tracings' quality rated with a 3° ordinal scale: (1) Interpretable without artifacts; (2) Interpretable with artifacts; (3) Uninterpretable.ResultsParticipants' median age was 36.6 years old, none having an I‐PSS > 5 or Peeling > 2. Overall 138 voidings were recorded (77 daytime, 61 nightly episodes). The device's ease of use, robustness, and portability obtained maximum score in 80% of evaluations. Most (98%) of the tracings were considered interpretable. Limitations included its small study population and short monitoring times.ConclusionThe construction of a cheap (<50 USD), accurate user‐friendly portable uroflowmeter proved feasible, which could facilitate access to portable uroflowmetry.
Assessing the impact of bag‐of‐words versus word‐to‐vector embedding methods and dimension reduction on anomaly detection from log files
Authors: Qiu Ziyu , Zhou Zhilei , Niblett Bradley , Johnston Andrew , Schwartzentruber Jeffrey , Zincir‐Heywood Nur , Heywood Malcolm I. 
Published: October 2023

AbstractIn terms of cyber security, log files represent a rich source of information regarding the state of a computer service/system. Automating the process of summarizing log file content represents an important aid for decision‐making, especially given the 24/7 nature of network/service operations. We perform benchmarking over eight distinct log files in order to assess the impact of the following: (1) different embedding methods for developing semantic descriptions of the original log files, (2) applying dimension reduction to the high‐dimensional semantic space, and (3) assessing the impact of using different unsupervised learning algorithms for providing a visual summary of the service state. Benchmarking demonstrates that (1) word‐to‐vector embeddings identified by bidirectional encoder representation from transformers (BERT) without “fine‐tuning” are sufficient to match the performance of Bag‐or‐Words embeddings provided by term frequency‐inverse document frequency (TF‐IDF) and (2) the self‐organizing map without dimension reduction provides the most effective anomaly detector.
Robust exponential stabilization and L2‐gain analysis for saturated switched nonlinear systems subject to actuator failure under asynchronous switching
Authors: Chen Wenxiang , Zhang Xinquan 
Published: October 2023

AbstractFor the nonlinear continuous‐time switched system with input saturation under asynchronous switching action, the problem of actuator failure is investigated in the presence of external disturbances. Firstly, a sufficient condition for the robust exponential stabilization of system is obtained by using the minimum dwell‐time method combining the piecewise Lyapunov function method. Secondly, a sufficient condition for the tolerance disturbances of the system is obtained by using the similar approach. Thirdly, the weighted ‐gain is analysed. Then, we maximize the estimation of the domain of attraction for the closed‐loop system by taking the shape of a set into consideration. Furthermore, the fault‐tolerant state feedback controllers are designed, which aim at enlarging the estimation of domain of attraction for the closed‐loop system and obtaining the maximum value of tolerance disturbance and the minimum upper bound on the weighted ‐gain. Last but not least, we give a numerical example to verify the effectiveness of the proposed approach and compare the state responses curve under the action of the fault‐tolerant and the standard controller.
Tobacco Cessation Following Laryngeal Cancer Diagnosis Predicts Response to Treatment and Laryngectomy‐Free Survival
Authors: Krutz Matthew , Acharya Pawan , Elliott Jacey , Zhao Daniel , Mhawej Rachad , Queimado Lurdes 
Published: October 2023

AbstractObjectiveTo determine the effect of tobacco cessation following laryngeal cancer diagnosis on response to first‐line therapy, laryngectomy‐free survival, and overall survival in patients who were current smokers at the time of diagnosis.Study DesignRetrospective, case‐control study.SettingOU Stephenson Cancer Center, National Cancer Institute‐Designated Cancer Center.MethodsWe included 140 patients diagnosed with laryngeal squamous cell carcinoma, who were current smokers at the time of diagnosis, and were treated with first‐line definitive radiation or chemo/radiation with the intent to cure. The association between patient characteristics and treatment response was assessed using the χ2 test and logistic regression analysis. Survival outcomes were analyzed using Kaplan‐Meier methods and Cox proportional‐hazards models.ResultsOf the 140 current smokers, 61 patients (45%) quit smoking prior to treatment initiation. In adjusted logistic regression analysis, quitters had 3.7 times higher odds of achieving a complete response to first‐line therapy than active smokers (odds ratio: 3.694 [1.575‐8.661]; P = .003). In the adjusted Cox proportional‐hazards model, quitters were 54% less likely to require salvage laryngectomy within 7 years of diagnosis than active smokers (hazard ratio: 0.456 [0.246‐0.848]; P = .013). Quitters had a statistically significant increase in 7‐year overall survival compared to active smokers (P = .02).ConclusionThis is the first study to show that in newly diagnosed laryngeal cancer patients who are current smokers at the time of diagnosis, tobacco cessation significantly increases therapy response, laryngectomy‐free survival, and overall survival. These data stress the importance of systematically incorporating tobacco cessation programs into laryngeal cancer treatment plans.
Norepinephrine transporter and vesicular monoamine transporter 2 tumor expression as a predictor of response to 131I‐MIBG in patients with relapsed/refractory neuroblastoma
Authors: Batra Vandana , Gikandi Ajami , Pawel Bruce , Martinez Daniel , Granger M. Meaghan , Marachelian Araz , Park Julie R. , Maris John M. , Vo Kieuhoa T. , Matthay Katherine K. , DuBois Steven G. 
Published: October 2023

AbstractBackgroundPrior studies suggest that norepinephrine transporter (NET) and vesicular monoamine transporter 2 (VMAT2) mediate meta‐iodobenzylguanidine (MIBG) uptake and retention in neuroblastoma tumors. We evaluated the relationship between NET and VMAT2 tumor expression and clinical response to 131I‐MIBG therapy in patients with neuroblastoma.MethodsImmunohistochemistry (IHC) was used to evaluate NET and VMAT2 protein expression levels on archival tumor samples (obtained at diagnosis or relapse) from patients with relapsed or refractory neuroblastoma treated with 131I‐MIBG. A composite protein expression H‐score was determined by multiplying a semi‐quantitative intensity value (0–3+) by the percentage of tumor cells expressing the protein.ResultsTumor samples and clinical data were available for 106 patients, of whom 28.3% had partial response (PR) or higher. NET H‐score was not significantly associated with response (≥PR), though the percentage of tumor cells expressing NET was lower among responders (median 80% for ≥PR vs. 90% for <PR; p = .0014). VMAT2 H‐score was not significantly associated with PR or higher versus less than PR, though patients with PR or higher had lower VMAT2 staining intensity (p = .005). VMAT2 H‐score was significantly lower in patients with complete response (median 40 vs. 210 for patients with <complete response; p = .0049). VMAT2 H‐scores were significantly higher in ganglioneuroblastoma (vs. neuroblastoma; p = .037), differentiated/poorly differentiated tumors (vs. undifferentiated; p = .0047), and tumors lacking MYCN amplification (vs. MYCN amplified; p = .0011).ConclusionsMarkers of lower NET and VMAT2 protein expression are associated with higher likelihood of response to 131I‐MIBG therapy in patients with relapsed/refractory neuroblastoma. Increased VMAT2 protein expression is associated with a more differentiated disease phenotype.
Registration of ‘GemCraft’ spring malting barley cultivar
Authors: Hu Gongshe , Evans Chris P. , Satterfield Kathy , Ellberg Sherry , Marshall Juliet M. , Schroeder Kurtis L. , Obert Don E. 
Published: October 2023

Abstract‘GemCraft’ (Reg. no CV‐379, PI 701910), is a two‐rowed spring malt barley (Hordeum vulgare L.) developed by the USDA‐ARS, Aberdeen, ID, in cooperation with the University of Idaho Agricultural Experiment Station, in 2023. The release is derived from the cross of 2B98‐5312/98Ab11993 and was advanced through the bulk pedigree method F1–F5. GemCraft has been tested at the USDA‐ARS, and all other cooperative trials, as line 2Ab08‐X05M010‐65. This cultivar has been tested across 32 location years under irrigated conditions and 13 location years in dryland conditions. GemCraft has shown similar yield to the current malting barley cultivar checks Voyager, Merit 57, M69, Conrad, and AC Metcalfe but has higher yield potential than ‘CDC Copeland’, M69, and ‘Harrington’ under irrigated conditions. In dryland trials, GemCraft has similar yield to the checks of Voyager and Conrad but higher yield than other checks. Malting quality evaluation results showed GemCraft has high extract, low protein, and competent values in other traits. All the evaluations suggested that GemCraft would be a good choice as a malting cultivar for craft brewers.
Grassland‐use intensity maps for Switzerland based on satellite time series: Challenges and opportunities for ecological applications
Authors: Weber Dominique , Schwieder Marcel , Ritter Lukas , Koch Tiziana , Psomas Achilleas , Huber Nica , Ginzler Christian , Boch Steffen 
Published: October 2023

AbstractLand‐use intensification in grassland ecosystems (i.e. increased mowing frequency, intensified grazing) has a strong negative effect on biodiversity and ecosystem services. However, accurate information on grassland‐use intensity is difficult to acquire and restricted to the local or regional level. Recent studies have shown that mowing events can be mapped for large areas using satellite image time series. The transferability of such approaches, especially to mountain areas, has been little explored, however, and the relevance for ecological applications in biodiversity and conservation has hardly been investigated. Here, we used a rule‐based algorithm to produce annual maps for 2018–2021 of grassland‐management events, that is, mowing and/or grazing, for Switzerland using Sentinel‐2 and Landsat 8 satellite data. We assessed the detection of management events based on independent reference data, which we acquired from daily time series of publicly available webcams that are widely distributed across Switzerland. We further examined the relationships between the generated grassland‐use intensity measures and plant species richness and ecological indicator values derived from a nationwide field survey. The webcam‐based verification for 2020 and 2021 revealed that most detected management events were actual mowing/grazing events (≥78%), but that a substantial number of events were not detected (up to 57%), particularly grazing events at higher elevations. We found lower plant species richness and higher mean ecological indicator values for nutrients and mowing tolerance with more frequent management events and those starting earlier in the year. A large proportion of the variance was explained by our use‐intensity measures. Our findings therefore highlight that remotely assessed management events can characterise land‐use intensity at fine spatial and temporal resolutions across broad scales and can explain plant biodiversity patterns in grasslands.
A Blood Drying Process for DNA Amplification
Authors: Lim Jongwon , Zhou Shuaizhen , Baek Janice , Kim Alicia Yeaeun , Valera Enrique , Sweedler Jonathan , Bashir Rashid 
Published: October 2023

AbstractThe presence of numerous inhibitors in blood makes their use in nucleic acid amplification techniques difficult. Current methods for extracting and purifying pathogenic DNA from blood involve removal of inhibitors, resulting in low and inconsistent DNA recovery rates. To address this issue, a biphasic method is developed that simultaneously achieves inhibitor inactivation and DNA amplification without the need for a purification step. Inhibitors are physically trapped in the solid‐phase dried blood matrix by blood drying, while amplification reagents can move into the solid nano‐porous dried blood and initiate the amplification. It is demonstrated that the biphasic method has significant improvement in detection limits for bacteria such as Escherichia coli, Methicillin‐resistant Staphylococcus aureus, Methicillin‐Sensitive Staphylococcus aureus using loop‐mediated isothermal amplification (LAMP) and recombinase polymerase amplification (RPA). Several factors, such as drying time, sample volume, and material properties are characterized to increase sensitivity and expand the application of the biphasic assay to blood diagnostics. With further automation, this biphasic technique has the potential to be used as a diagnostic platform for the detection of pathogens eliminating lengthy culture steps.
The Superaerophobic N‐Doped Carbon Nanocage with Hydrogen Spillover Effort for Enhanced Hydrogen Evolution
Authors: Zhang Yanyun , Yu Wenhao , Zhang Hao , Shi Yue , Zhu Jiawei , Wang Tiantian , Sun Yuyao , Zhan Tianrong , Lai Jianping , Wang Lei 
Published: October 2023

AbstractUnder the high current density, the excessive strong adsorption of H* intermediates and H2 accumulation the catalysts are the major obstacle to the industrial application of hydrogen evolation reaction (HER) catalysts. Herein, through experimental exploration, it is found that the superaerophobic Nitrogen (N)‐doped carbon material can promote the rapid release of H2 and provide H* desorption site for the hydrogen spillover process, which makes it have great potential as the catalysts support for hydrogen spillover. Based on this discovery, this work develops the hydrogen spillover catalyst with electron‐rich Pt sites loaded on N‐doped carbon nanocage (N‐CNC) with adjustable work function. Through a series of comprehensive electrochemical tests, the existence of hydrogen spillover effort has been proved. Moreover, the in situ tests showed that pyrrolic‐N can activate adjacent carbon sites as the desorption sites for hydrogen spillover. The Pt@N‐1‐CNC with the minimum work function difference (ΔΦ) between Pt NPs and support shows superior hydrogen evolution performance, only needs overpotential of 12.2 mV to reach current density of 10 mA cm−2, outstanding turnover frequency (TOF) (44.7 s−1@100 mV) and superior durability under the 360 h durability tests at current density of 50 mA cm−2.
Photo‐Controllable Smart Hydrogels for Biomedical Application: A Review
Authors: Zhao Yiwen , Ran Bei , Lee Dashiell , Liao Jinfeng 
Published: October 2023

AbstractNowadays, smart hydrogels are being widely studied by researchers because of their advantages such as simple preparation, stable performance, response to external stimuli, and easy control of response behavior. Photo‐controllable smart hydrogels (PCHs) are a class of responsive hydrogels whose physical and chemical properties can be changed when stimulated by light at specific wavelengths. Since the light source is safe, clean, simple to operate, and easy to control, PCHs have broad application prospects in the biomedical field. Therefore, this review timely summarizes the latest progress in the PCHs field, with an emphasis on the design principles of typical PCHs and their multiple biomedical applications in tissue regeneration, tumor therapy, antibacterial therapy, diseases diagnosis and monitoring, etc. Meanwhile, the challenges and perspectives of widespread practical implementation of PCHs are presented in biomedical applications. This study hopes that PCHs will flourish in the biomedical field and this review will provide useful information for interested researchers.
Redox‐Activatable Magnetic Nanoarchitectonics for Self‐Enhanced Tumor Imaging and Synergistic Photothermal‐Chemodynamic Therapy
Authors: Zheng Chongyang , Wang Zhen , Xu Hongtao , Huang Hailong , Tao Xiaofeng , Hu Yongjie , He Yue , Zhang Zhiyuan , Huang Xiaojuan 
Published: October 2023

AbstractOral squamous cell carcinoma (OSCC) is a prevalent malignancy of the head and neck region associated with high recurrence rates and poor prognosis under current diagnostic and treatment methods. The development of nanomaterials that can improve diagnostic accuracy and therapeutic efficacy is of great importance for OSCC. In this study, a redox‐activatable nanoarchitectonics is designed via the construction of dual‐valence cobalt oxide (DV‐CO) nanospheres, which can serve as a contrast agent for magnetic resonance (MR) imaging, and exhibit enhanced transverse and longitudinal relaxivities through the release and redox of Co3+/Co2+ in an acidic condition with glutathione (GSH), resulting in self‐enhanced T1/T2‐weighted MR contrast. Moreover, DV‐CO demonstrates properties of intracellular GSH‐depletion and hydroxyl radicals (•OH) generation through a Fenton‐like reaction, enabling strengthened chemodynamic (CD) effect. Additionally, DV‐CO displays efficient near‐infrared laser‐induced photothermal (PT) effect, thereby exhibiting synergistic PT‐CD therapy for suppressing OSCC tumor cells. It further investigates the tumor‐specific self‐enhanced MR imaging of DV‐CO both in subcutaneous and orthotopic OSCC mouse models, and demonstrate the therapeutic effects of DV‐CO in orthotopic OSCC mouse models. Overall, the in vitro and in vivo findings highlight the excellent theranositc potentials of DV‐CO for OSCC and offer new prospects for future advancement of nanomaterials.
Adaptation to Change in Reindeer Husbandry in the Republic of Sakha (Yakutia), Russia
Authors: Gerasimova Alena , Avelova Svetlana , Lutz Julia , Moiakunova Anisiia , Petrova Aleksandra , Pogodaev Mikhail , Popova Lena , Shadrin Vyacheslav , Shishigina Anna , Zhozhikov Anatoly , Mathiesen Svein Disch 
Published: October 2023

AbstractWith 170,000 domestic reindeer and 1295 reindeer herders, the Republic of Sakha (Yakutia) is a vital region for the reindeer herding economy. The Republic is the homeland of five Indigenous peoples that herd reindeer – Evenki, Even, Dolgan, Yukaghir, and Chukchi.The paper looks at the history and characteristics of Yakutia’s reindeer herding and herding peoples and analyzes the transformation of the traditional reindeer husbandry model into a collectivized industry from the 1930s. Loss of pastures, predators, and decline of traditional knowledge are affecting reindeer herders, with climate change exacerbating the problems. Another aim of the paper is to show the impact of climate change on the reindeer herding development through the example of four reindeer herding regions of Yakutia from the north to the south. In this regard, the article examines the climate change trends and, in a historical retrospective, the economic settings of this traditional nature management sector, which employs only the Indigenous peoples of the North. The identified climate change trends suggest that climate warming combined with other economic transformations has diverse effects on reindeer husbandry in the four districts under investigation.The findings indicate that challenges such as loss to predators, loss of grazing land, and decline in traditional knowledge preservation affect herding communities already affected by climate change. The authors highlight the relevance of engaging Indigenous reindeer herding communities and their traditional knowledge in developing mechanisms for adaptation to climate change and predation. It is essential to support herders in their aspiration to decide their destiny and strengthen the family-based economy.