bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningkatkan Pengetahuan Remaja Dalam Penggunaan Antibiotik Di Pondok Pesantren Darul Istiqamah Kalimantan Selatan
Authors: Aryzki Saftia , Melviani Melviani 
Published: October 2023

Antibiotik merupakan obat untuk pengobatan infeksi yang disebabkan oleh berbagai bakteri. Antibiotik saat ini banyak beredar di masyarakat sebagai salah satu obat umum. Periode awal remaja adalah masa transisi menuju tahap dewasa. Kegiatan ini bertujuan untuk meningkatkan pengetahuan remaja dalam penggunaan antibiotik. Kegiatan dilakukan pada hari Sabtu, 23 Juli 2022 di Pondok Pesantren Darul Istiqamah secara daring. Jumlah peserta dalam kegiatan ini sebanyak 31 orang yaitu terdiri dari perwakilan kelas X, kelas XI dan kelas XII SMA. Metode pelaksanaan kegiatan pengabdian masyarakat ini adalah dengan menggunakan metode ceramah. Metode ini dilakukan dengan memberikan edukasi secara langsung menggunakan media power point. Hasil penyuluhan siswa SMA Pondok Pesantren Darul Istiqomah dengan nilai pretes baik sebanyak 10 siswa (32,25%) dan buruk sebanyak 21 siswa (67,74%). Setelah pemberian penyuluhan dilakukan penilaian kembali dengan nilai postest baik sebanyak 23 siswa (74,19%) dan buruk sebanyak 8 siswa (25,8%). Kesimpulan dari penyuluhan ini dapat meningkatkan pengetahuan siswa dalam hal ini remaja dalam penggunaan antibiotik. Kata Kunci: Antibiotik, Remaja, Penyuluhan, Resistensi Antibiotics are drugs to prevent and treat infections caused by bacteria. As one of the common types of drugs, antibiotics are widely circulated in the community. The early adolescent stage is a transitional period from the stage of adulthood. The activity was carried out on Saturday, 23 July 2022 at the Darul Istiqamah Islamic Boarding School in a brave manner. The number of participants in this activity was 31 people consisting of representatives from class X, class XI and class XII SMA. The implementation method in this community service activity is a lecture. This method is done by providing education directly with power point media. The results of the counseling showed that there were differences in knowledge of the use of antibiotics in students of SMA Pondok Pesantren Darul Istiqomah with good pretest scores of 10 students (32.25%) and bad as many as 21 students (67.74%). After the counseling was given, a re-judgment was carried out with good posttest scores for 23 students (74.19%) and bad for 8 students (25.8%). The conclusion of this counseling can increase students' knowledge in this case teenagers in the use of antibiotics.
Upaya Pembudidayaan dan Pemanfaatan Tanaman Obat Keluarga (TOGA) di Desa Tungkaran, Kecamatan Martapura
Authors: Rizki Muhammad Ikhwan , Sari Anna Khumaira , Normaidah Normaidah 
Published: October 2023

Tanaman obat keluarga terdiri atas beberapa jenis tanaman obat yang ditanam di halaman atau di lingkungan sekitar rumah. Pemanfaatan tanaman sebagai obat memerlukan informasi agar tidak terjadi kesalahan terkait kandungan, khasiat, dan cara pengolahan. Kegiatan ini dilakukan bertujuan untuk meningkatkan pengetahuan Masyarakat di Desa Tungkaran Kecamatan Martapura Kabupaten Banjar Kalimantan Selatan tentang pemanfaatan tanaman obat keluarga dan memberikan informasi mengenai kandungan dan khasiat dari beberapa jenis tanaman obat keluarga. Metode pengabdian dilakukan dengan metode penyuluhan dengan media buku saku terkait manfaat tanaman obat keluarga serta pembuatan kebun tanaman obat keluarga, sehingga tanaman obat yang sudah ditanam dapat dimanfaatkan oleh warga. Evaluasi yang digunakan berupa pretest, keaktifan peserta, dan posttest. Perolehan hasil pretest yang sudah dilakukan oleh warga Desa Tungkaran didapatkan nilai rata-rata yaitu sebesar 60%, sedangkan untuk perolehan hasil posttest didapatkan nilai rata-rata yaitu sebesar 85%. Angka ini mengalami kenaikan setelah pemberian materi tentang penanaman dan pemanfaatan TOGA. Hal tersebut menunjukkan bahwa terjadi peningkatan pengetahuan yang menunjukkan bahwa peserta pengabdian dapat menerima dengan baik materi yang telah diberikan.Kata Kunci: Pemanfaatan, Sosialisasi, Tanaman Obat KeluargaFamily medicinal plants consist of several types of medicinal plants grown in the yard or in the neighborhood. The utilization of plants as medicine requires information to avoid errors related to the content, efficacy, and processing methods. This activity was carried out with the aim of increasing community knowledge in Tungkaran Village, Martapura Sub-district, Banjar Regency, South Kalimantan about the utilization of family medicinal plants and providing information about the content and efficacy of several types of family medicinal plants. The method of service is carried out by counseling methods with pocket book media related to the benefits of family medicinal plants and the creation of a centralized family medicinal plant garden, so that medicinal plants that have been planted can be utilized by residents. The evaluation used is in the form of pretest, participant activeness, and posttest. The pretest results obtained by the residents of Tungkaran Village obtained an average value of 60%, while the posttest results obtained an average value of 85%. This figure has increased after providing material on planting and utilizing TOGA. This shows that there is an increase in knowledge which shows that the service participants can accept the material that has been given well.
Pemetaan Serangan Penyebab Penyakit Busuk Batang Jagung di Kabupaten Tanah Laut, Kalimantan Selatan
Authors: Oktaviani Winda Rizky , Salamiah Salamiah , Fitriyanti Dewi 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui keberadaan dan sebaran serta luasan serangan penyakit busuk batang tanaman jagung di Kabupaten Tanah Laut Kalimantan Selatan. Penelitian ini dilaksanakan pada bulan Maret – Juli 2022. Pengambilan sampel dilakukan di 10 Kecamatan yang ada di Kabupaten Tanah Laut yaitu kecamatan Bajuin, Batu Ampar, Bati-bati, Kintap, Kurau, Panyipatan, Pelaihari, Takisung dan Tambang Ulang yang menanam jagung dari 11 kecamatan yang ada di Kabupaten Tanah Laut. Pengamatan tanaman sampel dilakukan dengan mengamati gejala yang ada pada masing-masing Kecamatan yang diambil dari tiga desa yang menanam tanaman jagung dan setiap desa diambil 3 lokasi pertanaman jagung. Masing-masing desa yang menjadi titik sampel yang terdiri dari masing-masing 5 sampel yang diambil secara diagonal. Masing-masing titik terdiri dari 100 tanaman jagung sehingga jumlah tanaman yang diamati setiap lokasi pertanaman sebanyak 500 tanaman. Berdasarkan hasil pengamatan penyebab penyakit busuk batang jagung yang disebabkan oleh cendawan dan bakteri tersebar di seluruh kecamatan yang menanam jagung di Kabupaten Tanah Laut dengan intensitas serangan yang beragam.
Uji Lapang Aplikasi Trichoderma sp dan PGPR dalam Menekan Kejadian Penyakit Antraknosa Pada Cabai Rawit Hiyung
Authors: Adiyatama Muffizar Darmawan , Mariana Mariana , Budi Ismed Setya 
Published: October 2023

Cabai rawit hiyung adalah salah satu cabai rawit lokal yang berasal dari Desa Hiyung Kecamatan Tapin Tengah Kabupaten Tapin, Provinsi Kalimantan Selatan. Antraknosa merupakan penyakit utama pada tanaman cabai yang sangat merugikan karena penyakit ini menyebabkan busuk pada buah cabai sehingga sangat menurunkan nilai jual hasil panennya. Intensitas penyakit antraknosa semakin meningkat pada cabai hiyung di Desa Hiyung Kalimantan Selatan, hingga rata-rata 45,59%. Penelitian ini dilaksanakan pada lahan pertanaman cabai di Desa Hiyung menpergunakan metode rancangan acak lengkap yang terdiri dari 4 perlakuan yaitu kontrol tanpa aplikasi Trichoderma sp dan PGPR, aplikasi Trichoderma sp . aplikasi PGPR dan aplikasi Trichoderma sp + PGPR. Hasil penelitian menunjukan bahwa perlakuan PGPR dapat menurunkan kejadian penyakit antraknosa hanya 9,18%, sedangkan perlakuan Trichoderma sp 13,959% dan perlakuan Trichoderma sp + PGPR 14,47% tidak dapat menurunkan presentasi kejadian penyakit antraknosa terhadap cabai rawit hiyung di lahan rawa. Pada pengamatan jumlah buah setelah aplikasi relatif tidak berpengaruh antar perlakuan kontrol (644 buah), perlakuan Trichoderma sp (552,75 buah), perlakuan PGPR (661 buah) dan perlakuan Trichoderma sp + PGPR (657,5 buah). Pengamatan berat buah sehat dan sakit relatif tidak berpengaruh antar perlakuan kontrol (499,55 gram) sehat (6,18 gram) sakit, perlakuan Trichoderma sp (517,6 gram) sehat (14,58 gram) sakit, perlakuan PGPR (618.57 gram) sehat (16,27 gram) sakit dan perlakuan Trichoderma sp + PGPR (548,74 gram) sehat (12,68 gram) sakit. Pada pengamatan tinggi tanaman juga tidak berpengaruh antara perlakuan kontrol (61,33 cm), perlakuan Trichoderma sp (66,83 cm), perlakuan PGPR (64,03 cm) dan perlakuan Trichoderma sp + PGPR (65,42 cm)
To Close is Impossible to Leave it: Where Should be Put a Comma?
Authors: Pleshkevich E. A. 
Published: October 2023

The article is a response to the article by V. K. Stepanov “A great reduction in quantity of libraries: particular management errors or a general perspective for the field (analysis of the experience of the Moscow region)”, published in the previous issue of Bibliosphere. Three main theoretical and methodological contradictions that reduce the reliability of the results obtained by the author and the validity of the recommendations proposed by him for regional librarianship are identified and analyzed.The first of them concerns the departure from the principle of historicism, as well as the complexity of the consideration of the phenomenon under study, and as a result the social nature of librarianship is presented incorrectly by the author of the article. It is noted that the basic social function determining the vector of domestic library construction was the function of educating a Soviet person, his ideological, cultural, scientific and technical enlightenment through the guidance of book reading in a specially selected library fund. Intermediary functions were associated with the shortcomings of book publishing in the field of leisure literature and played a secondary role. Thus, automation and computerization of book publishing and bookselling affect librarianship only indirectly, since the material nature of book publishing does not affect the cultural and educational functions of libraries.The second contradiction is related to the correctness of the analysis and interpretation of statistical data reflecting the process of library development in the Moscow region. The analysis of statistics shows that the negative dynamics in regional library construction is caused by the process of reduction of settlements, its natural decline and aging of the population. The increase in the number of users of municipal libraries indicates that the reduction in the number of libraries does not lead to a decrease in the level of library services of the population.The third contradiction concerns following the principle of scientific objectivity of research. The author noted only negative trends, leaving regional library construction programs aimed at the development of model libraries outside the scope of his analysis.
Graves Disease is Associated with Increased Risk of Clinical Alzheimer’s Disease: Evidence from the Medicare System
Authors: Yashkin Arseniy Pavlovich , Kolpakov Stanislav , Ukraintseva Svetlana , Yashin Anatoliy , Akushevich Igor 
Published: October 2023

Abstract
Background
Identification of modifiable risk factors for Alzheimer’s Disease (AD) onset is an important aspect of controlling the burden imposed by this disease on an increasing number of older U.S. adults. Graves disease (GD), the most common cause of hyperthyroidism in the U.S., has been hypothesized to be associated with increased AD risk, but there is no consensus. In this study, we explore the link between GD and risk of clinical AD.
Methods
Cox and Fine-Grey models were applied to a retrospective propensity-score-matched cohort of 15,505 individuals with GD drawn from a nationally representative 5% sample of U.S. Medicare beneficiaries age 65 + over the 1991–2017 period.
Results
Results showed that the presence of GD was associated with a higher risk of AD (Hazard Ratio [HR]:1.15; 95% Confidence Interval [CI]:1.07–1.23). Magnitude of associated risk varied across subgroups: Males (HR:1.19; CI:1.01–1.41), Females (HR:1.09; CI:1.02–1.18), Whites (HR:1.13; CI:1.04–1.20), Blacks (HR:1.33; CI:1.04–1.20). Competing risk estimates were consistent with these findings.
Conclusions
A potential mechanism connecting GD and AD may involve shared etiological factors between the two diseases. Although replication of our findings is needed, they suggest that GD prevention and treatment may contribute to reducing the burden of AD in U.S. older adults.
Socioeconomic and environmental determinants of Foot and Mouth Disease Incidence: An ecological, cross-sectional study across Iran using spatial modeling
Authors: Ashani Mahdi Nazari , Alesheikh Ali Asghar , Samani Zeinab Neisani , Lotfata Aynaz , Bayat Sayeh , Alipour Siamak , Hoseini Benyamin 
Published: October 2023

Abstract
Foot-and-mouth disease (FMD) is a highly contagious animal disease caused by a ribonucleic acid (RNA) virus, with significant economic costs and uneven distribution across Asia, Africa, and South America. While spatial analysis and modeling of FMD are still in their early stages, this research aimed to identify socio-environmental determinants of FMD incidence in Iran at the provincial level by studying 135 outbreaks reported between March 21, 2017, and March 21, 2018. We obtained 46 potential socio-environmental determinants and selected four variables, including percentage of population, precipitation in January, percentage of sheep, and percentage of goats, to be used in spatial regression models to estimate variation in spatial heterogeneity. In our analysis, we employed global models, namely Ordinary Least Squares (OLS), Spatial Error Model (SEM), and Spatial Lag Model (SLM), as well as local models, including Geographically Weighted Regression (GWR) and Multiscale Geographically Weighted Regression (MGWR). The MGWR model yielded the highest adjusted of 90%, outperforming the other local and global models. Using local models to map the effects of environmental determinants (such as the percentage of sheep and precipitation) on the spatial variability of FMD incidence provides decision-makers with helpful information for targeted interventions. Our findings advocate for multiscale and multidisciplinary policies to reduce FMD incidence.
Rapid morphological change in UK populations of Impatiens glandulifera
Authors: Wyatt Amy Louise , Pardoe Heather , Cleal Christopher , Sanchez-Vilas Julia 
Published: October 2023

Abstract

The highly invasive Impatiens glandulifera (Himalayan balsam) is one of the most prolific and widespread invasive plants in the British isles. Introduced in the early 19th century, it has now been reported in almost every vice county across the U.K and is a fierce competitor that has adverse effects on the local community structure. Despite the negative impacts that invaders like I. glandulifera have on local communities, there have been very few studies which address the morphological changes that invasive plant populations have undergone since their initial introduction. This is the first study of its kind to investigate the morphological changes that have occurred in I. glandulifera since 50 years after its introduction. 319 herbarium specimens dating from 1890–2017 were used to measure changes in morphological traits such as leaf size, flower size and stomatal characteristics. We found that since 1890, there has been a significant reduction in overall leaf size, a significant reduction in stomatal density and a significant increase in the overall flower size. These results highlight the importance of monitoring the evolutionary change in prolific alien species over the course of their invasion, providing useful insights into changes in competitive ability which may prove useful in managing dispersal and providing options for potential management.
AI-driven microbial sequencing analysis for hydrogen storage in the Maari reservoir
Authors: Katterbauer Klemens , Qasim Abdulaziz , Shehri Abdallah Al , Yousef Ali 
Published: October 2023

Abstract

Hydrogen storage in subsurface reservoirs has been of great interest in order to overcome seasonal demand and supply discrepancies. Hydrogen is a good energy carrier, whose combustion process solely leads to energy and water as output and can be utilized as an energy storage carrier. Hydrogen’s high energy density can be very beneficial as a reactant for several chemical processes. Given the growing utilization of hydrogen for supporting the energy transition, hydrogen can be stored in various ways, such as metal tanks and in underground subsurface environments. Furthermore, hydrogen may be stored in the form of a mixture of natural gas, materials and in deep geological structures. Underground natural gas storage has been conducted for a long time in porous rock formations and salt caverns and given the massive amounts of hydrogen that have to be stored, subsurface hydrogen storage has been of significant interest. Given the limited experience for underground hydrogen storage and most of the hydrogen storage experience has been in salt caverns. We have developed a data-driven framework for the analysis of microbial effects on subsurface hydrogen storage. The framework integrates 16S rRNA sequencing data from subsurface hydrogen storage sites to analyze their composition and deduce potential effects on the hydrogen productivity from the reservoir. The framework was evaluated on a simulated Maari subsurface hydrogen storage and exhibited strong classification performance and prediction of estimated hydrogen recovery from the subsurface environment.
Population genetic structure of the exotic smooth cordgrass Spartina alterniflora and its invasion into Korean coasts
Authors: Muhammad Buhari Lawan , Lee Kanghyun , Yoon Wonduk , Chae Jinho , Ki Jang-Seu 
Published: October 2023

Abstract
The smooth cordgrass, Spartina alterniflora Loisel, is an aggressive invasive species that causes a significant negative impact on coastal ecosystems worldwide. The species is native to the eastern United States, but has spread rapidly along East Asian coasts and was unintentionally introduced into Korea, leading to the devastation of native ecosystems. Here, we examined the population genetic structure and invasion pathway of S. alterniflora along Korean coasts using chloroplast DNA (cpDNA). Our results revealed that the S. alterniflora population in Korea has a strong genetic structure, primarily consisting of two geographically isolated haplotypes (C1 and C4). Furthermore, two individuals were found to have haplotype N, which might be a newly discovered haplotype in this study. The haplotypes C1 and C4 are widely distributed in the native population as well as in the introduced population in East Asia. Thus, the presence of these two haplotypes in different localities in Korea suggests multiple invasion events. Comparisons of the cpDNA data of this study with the available GenBank data from the native range in the U.S. and the invasive range in East Asia (China and Japan) revealed that the East Asian population (China, Japan, and Korea) is nearly homogeneous (AMOVA; Fst = 0.06871, p = 0.5) with no restricted gene flow. Our study suggests that the C1 and C4 haplotypes might have been introduced into Korea multiple times particularly from China, possibly via natural dispersal or transport vectors. These emphasize the importance of strengthening coastal management to prevent further spread.
The clinical trial of alternative Relugolix administration for uterine leiomyoma prior to surgically treatment: a study protocol for Non-Adverse Relugolix Administration (NARA) trial
Authors: Kawahara Naoki , Kawaguchi Ryuji , Yamamoto Konosuke , Nishikawa Kyohei , Matsuoka Motoki , Maehana Tomoka , Fukui Yosuke , Yamanaka Shoichiro , Sugimoto Sumire , Iwai Kana , Yamada Yuki , Kurakami Hiroyuki , Hirata Takumi , Takashima Ryuzo , Suzuki Shota , Asada Kiyoshi , Kasahara Masato , Kimura Fuminori 
Published: October 2023

Abstract
Background: Uterine leiomyomas are common for reproductive-aged women and affect women’s quality of life due to heavy menstrual bleeding or dysmenorrhea. Leiomyomas grow according to estradiol exposure and decrease after post-menopause. In case serious symptoms are caused by leiomyomas, pharmacotherapy or surgical treatment is proposed. Prior to surgical treatment, pharmacotherapies aimed at reduction of leiomyoma and uterine volume or improvement of anemia are introduced to conduct minimum invasive surgery(i.e., to reduce blood loss or surgical duration). Recently relugolix(40mg orally once daily) as a gonadotropin-releasing hormone (GnRH) receptor antagonist has proved its sufficient efficacy in suppressing estradiol levels without the transient estradiol flare-up compared with GnRH agonist. However long-term administration should not be permitted liable to for climacteric disorder or osteoporosis. And evidence is lacking on the actual efficacy and extent of adverse effects of the every other day dosing regimen. This trial aimed to prove non-inferiority in volume reduction effect on leiomyoma and safety(i.e., reduction of adverse effects) by every other day administration after two months of everyday administration compared to daily administration throughout the duration.
Methods: A minimization adaptive randomized control trial(RCT) will be conducted. Patients(over 20 years old) harboring leiomyoma who will be undergoing surgical treatment will be invited to participate. Patients who are enrolled in the intervention group will receive every other day administration for 16 weeks after eight weeks of daily administration. Patients who are enrolled in the control group will receive daily throughout the 24 weeks. The primary outcome is the leiomyoma volume change rate and the secondary endpoints are the change rate of uterine volume, the occurrence of the climacteric disorder, genital bleeding days, change rate of serum hormone or bone turnover markers, and bone mineral density after 24 weeks compared to before administration.
Discussion: This study will aim to prove both the non-inferiority in leiomyoma volume reduction and superiority in adverse effects occurrence reduction, which will provide a novel method to escape adverse effects with maintaining the effect of leiomyoma reduction.
Trial registration: jRCTs051230078, registered 26 July 2023.
Development of Pseudosacral Cyst Following Surgery for Primary Presacral Neuroendocrine Tumors with Liver Metastasis: A Case Report
Authors: jian Li , Wang Youheng , yu hao , ding zhao , Wan Songlin , li daojiang , qian qun 
Published: October 2023

Abstract

Introduction:Presacral neuroendocrine tumors (PSNET) are a rare disease that currently lacks a standardized treatment approach. In this report, we present a unique case of PSNET with liver metastasis that progressed into a pseudosacral cyst following complete surgical resection and Sulfatinib treatment with radiofrequency ablation.case summary: A 49-year-old woman presented to our department with hematochezia. Magnetic resonance imaging revealed a presacral mass with liver metastasis. We performed a complete resection of the mass through a transperineal approach and a terminal ileostomy. Postoperative pathology confirmed a G2 neuroendocrine tumor. After multidisciplinary consultation, the patient received targeted treatment with Sulfatinib and underwent radiofrequency ablation of the liver tumors using fluorescence laparoscopy. Six months later, the patient developed an anterior sacral pseudocyst, which required surgical intervention.Conclusion:Before undergoing surgical treatment for presacral neuroendocrinology, it is important to consider the potential risks of poor healing of the presacral incision and formation of pseudocysts. These complications may be caused by various factors, including the procedure itself and the use of targeted drugs.