bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model
Authors: Abrahams Dominique , Ibrahim-Hashim Arig , Ackerman Robert S. , Brown Joel S. , Whelan Christopher J. , Garfinkel Megan B. , Gatenby Robert A. , Muncey Aaron R. 
Published: October 2023

IntroductionVolatile and intravenous anesthetics may worsen oncologic outcomes in basic science animal models. These effects may be related to suppressed innate and adaptive immunity, decreased immunosurveillance, and disrupted cellular signaling. We hypothesized that anesthetics would promote lung tumor growth via altered immune function in a murine model and tested this using an immunological control group of immunodeficient mice.MethodsLewis lung carcinoma cells were injected via tail vein into C57BL/6 immunocompetent and NSG immunodeficient mice during exposure to isoflurane and ketamine versus controls without anesthesia. Mice were imaged on days 0, 3, 10, and 14 post-tumor cell injection. On day 14, mice were euthanized and organs fixed for metastasis quantification and immunohistochemistry staining. We compared growth of tumors measured from bioluminescent imaging and tumor metastasis inex vivobioluminescent imaging of lung and liver.ResultsMetastases were significantly greater for immunocompromised NSG mice than immunocompetent C57BL/6 mice over the 14-day experiment (partial η2= 0.67, 95% CI = 0.54, 0.76). Among immunocompetent mice, metastases were greatest for mice receiving ketamine, intermediate for those receiving isoflurane, and least for control mice (partial η2= 0.88, 95% CI = 0.82, 0.91). In immunocompetent mice, significantly decreased T lymphocyte (partial η2= 0.83, 95% CI = 0.29, 0.93) and monocyte (partial η2= 0.90, 95% CI = 0.52, 0.96) infiltration was observed in anesthetic-treated mice versus controls.ConclusionsThe immune system appears central to the pro-metastatic effects of isoflurane and ketamine in a murine model, with decreased T lymphocytes and monocytes likely playing a role.
Micro-doppler radar to evaluate risk for musculoskeletal injury: Protocol for a case-control study with gold standard comparison
Authors: Abou Al Ardat Bilal , Nyland Jennifer , Creath Robert , Murphy Terrence , Narayanan Ram , Onks Cayce 
Published: October 2023

Background
Beyond causing significant morbidity and cost, musculoskeletal injuries (MSKI) are among the most common reasons for primary care visits. A validated injury risk assessment tool for MSKI is conspicuously absent from current care. While motion capture (MC) systems are the current gold standard for assessing human motion, their disadvantages include large size, non-portability, high cost, and limited spatial resolution. As an alternative we introduce the Micro Doppler Radar (MDR); in contrast with MC, it is small, portable, inexpensive, and has superior spatial resolution capabilities. While Phase 1 testing has confirmed that MDR can identify individuals at high risk for MSKI, Phase 2 testing is still needed. Our aims are to 1) Use MDR technology and MC to identify individuals at high-risk for MSKI 2) Evaluate whether MDR has diagnostic accuracy superior to MC 3) Develop MDR algorithms that enhance accuracy and enable automation.

Methods and findings
A case control study will compare the movement patterns of 125 ACL reconstruction patients to 125 healthy controls. This study was reviewed and approved by the Pennsylvania State University Human Research Protection Program (HRPP) on May 18, 2022, and the IRB approval number is STUDY00020118. The ACL group is used as a model for a “high risk” population as up to 24% will have a repeat surgery within 2 years. An 8-camera Motion Analysis MC system with Cortex 8 software to collect MC data. Components for the radar technology will be purchased, assembled, and packaged. A micro-doppler signature projection algorithm will determine correct classification of ACL versus healthy control. Our previously tested algorithm for processing the MDR data will be used to identify the two groups. Discrimination, sensitivity and specificity will be calculated to compare the accuracy of MDR to MC in identifying the two groups.

Conclusions
We describe the rationale and methodology of a case-control study using novel MDR technology to detect individuals at high-risk for MSKI. We expect this novel approach to exhibit superior accuracy than the current gold standard. Future translational studies will determine utility in the context of clinical primary care.
Association of Jewish Libraries Biographical Directory
Authors: Association of Jewish Libraries  
Published: October 2023

The 1991 AJL Directory is not available because it includes personal information and was supposed to be shared among the association members only at the time. The text of the original Interlocution is provided here in lieu of the full directory.
As the originally designated editor of what was to have been a 25th Anniversary Volume, Herbert C. Zafren conceived of the Association of Jewish Libraries' Biographical Directory as part of the volume because he felt that it would increase the reference value of the work and provide valuable information for writing the actual history of the Association. In 1988, Zafren designed the questionnaire and had the form mailed to the then current membership. As names of former AJL members were submitted, questionnaires were sent to them as well; there was no way to systematically contact all former members. Even after many responses had been received, there was still a sense that members who might wish to be included had not yet been reached. Therefore, in October 1990, Dr. Ralph Simon prepared a second mailing to the membership. This second mailing resulted in the receipt of several hundred additional forms, many of which were updated versions of information submitted from the first mailing. As the completed forms were received, they were edited, and later updated, by Marcia Posner, who sent the data to Laurel Wolfson, who compiled the entries and input the data into a computerized database. The total number of entries in the directory is 429, while the current membership of AJL stands at 1,048; the latter figure includes 74 institutional members. In sum, this Biographical Directory includes current and former AJL members who received and responded to the questionnaire.
Monocyte distribution width as an early predictor of short-term outcome in adult patients with sepsis
Authors: Liu Yin , Wang Ruizhi , Zhong Shihua , Qian Liu , Wang Dong 
Published: October 2023

Abstract

Objectives
Monocyte distribution width (MDW) is a quantitative measurement of monocyte anisocytosis and has been proposed as an efficient marker for early sepsis detection. This study aimed to assess the prognostic potential of MDW in septic patients.

Methods
In this study, a total of 252 adult septic patients were enrolled. Demographic, clinical, and laboratory finding including MDW and traditional inflammatory biomarkers detected at three time points (day 1, day 3 and day 6) after admission were collected and compared between 28-day survivors and non-survivors. Receiver operating characteristic (ROC) curves, Kaplan-Meier survival curve and Cox regression analyses were performed to assess and compare their predictive values. Group-based trajectory modeling was applied to identify MDW trajectory endotypes. Basic characteristics and 28-day outcomes were compared between the trajectories.

Results
ROC curve analysis showed that MDW levels measured on day 3 after admission (D3-MDW) had moderate prognostic value and was independently associated with 28-day mortality in patients with sepsis. A D3-MDW value of 26.20 allowed discrimination between survivors and non-survivors with a sensitivity of 77.8 % and a specificity of 67.6 %. However, the prognostic accuracy of D3-MDW was diminished in immune-compromised patients and patients who already received antibiotics before admission. Group-based trajectory modeling indicated that excessively elevated and delayed decreased MDW levels during the first week after admission inversely correlated with prognosis.

Conclusions
MDW values detected on day 3 after admission and its kinetic change might be potential markers for predicting short-term outcome in adult septic patients.
The progress of cathode materials in aqueous zinc-ion batteries
Authors: Zhou Xinchi , Jiang Shan , Zhu Siao , Xiang Shuangfei , Zhang Zhen , Xu Xiangyu , Xu Yuanyuan , Zhou Jian , Tan Suchong , Pan Zhengdao , Rao Xingyou , Wu Yutong , Wang Zhoulu , Liu Xiang , Zhang Yi , Zhou Yunlei 
Published: October 2023

Abstract
Rechargeable aqueous zinc-ion batteries (AZIBs), a promising energy storage device in the large-scale energy storage market, have attracted extensive attention in recent years due to their high safety, low cost, environmental friendliness, and excellent electrochemical performance. Despite the rapid development of AZIBs technology, challenges such as insufficient energy density and limited cycling life still exist, which hinders the practical application of AZIBs. Due to the critical role that cathode materials play in the electrochemical performance of AZIBs, it is necessary to summarize the progress of cathode materials for AZIBs. In this review, the Zn2+ storage mechanisms of the cathode materials are analyzed. Subsequently, the representative cathode materials are introduced, and their structures and electrochemical performances are compared. The existing problems and improvement strategies of these cathode materials are summarized in detail. Finally, the future challenges and promising prospects for cathode materials are proposed. This review will guide researchers and manufacturers, benefiting them in designing advanced AZIBs for grid-scale energy storage.
Peranan Coca-Cola Foundation Dalam Mengembangkan Perpustakaan Berbasis Inklusi Sosial di Dinas Perppustakan dan Kearsipan Lubuklinggau
Authors: Kusumawatie Nirmala 
Published: October 2023

Salah satu cara untuk meningkatkan layanan perpustakaan adalah dengan ermitra dengan organisasi lain seperti perguruan tinggi pemerintah pulik dan perusahaan swasta. Seagaimana dijelaskan dalam Undang-Undang Nomor 3 Tahun 2007 Pasal 2 perpustakaan berhak ekerjasama dengan eragai pihak untuk meningkatkan pelayanan perpustakaan. Kolaborasi antar perpustakaan ini dimaksudkan untuk memerikan akses yang leih luas ke koleksi meningkatkan layanan kepada pengguna dan meningkatkan operasi di berbagai sumber. Penelitian ini merupakan penelitian deskriptif kualitatif dengan menggunakan metode studi kasus pada Dinas Perpustakaan dan Kearsipan Lubuklinggau. Hasil penelitian menunjukkan bahwa peran CocaCola Indonesia Foundation dalam mengemangkan layanan erasis inklusi sosial di Dinas Perpustakaan dan Kearsipan Luuklinggau adalah menjalin kerjasama dalam bentuk program PerpuSeru melalui tiga cara khususnya dengan memobilisasi Perpustakaan dan Arsip Lubuklinggau. Staf layanan dan masyarakat untuk menyediakan layanan dan penggunaan TIK dan membentuk masyarakat Lubuklinggau menjadi masyarakat yang spesifik sektor sektor dan industri di mana mereka terlihat.
Travel and Anxiety in Early Jewish Literature
Authors: Uusimäki Elisa 
Published: October 2023

Abstract
While some early Jewish texts highlight opportunities enabled by travel, others reflect related concerns, suggesting that an encounter with the unknown moves people not only physically but also emotionally. This article addresses the latter phenomenon by investigating the blend of travel and anxiety in a selection of passages from Jubilees, Tobit, Aramaic Levi Document, and Philo of Alexandria. Drawing on affect theory, it argues that travel-related anxiety is best understood as an inclusive affect covering both explicit and more unspoken or fuzzy forms of anxiety, which can be either acute or chronic in nature. Seeking to map out a range of ancient responses to or strategies of managing apprehensions, I demonstrate that the selected sources reflect both emotional and ethical concerns. The authors of narrative texts invite their audiences to immerse themselves in “historical” events and to share the emotionally taxing aspect of relocations undertaken by ancestral figures in the past, while the authors of instructional texts address current experiences arising from their own communities: they mitigate possible worries related to encountering competing claims of wisdom on the move and instruct against trips driven by a greedy pursuit of luxurious goods.
Importancia de la gestión del cuidado de enfermería en la atención del paciente con diagnóstico de enfermedad de Von Willebrand en colombia
Authors: ROMERO OVALLE YEIMY NATALIA 
Published: October 2023

Introducción
La enfermedad de Von Willebrand, es considerada como uno de los trastornos hereditarios hemorrágicos más frecuentes, el cual se caracteriza por un defecto cuantitativo, cualitativo o funcional del nivel de factor de Von Willebrand (FVW) lo cual ocasiona dificultades para el proceso de hemostasia. Se clasifica en tres tipos; Tipo I, Tipo II y Tipo III, afectando a la población femenina y masculina en igual medida. Razón por la cual requieren de intervenciones de cuidado específicas por parte del profesional de enfermería para garantizar el mantenimiento de la salud y prevenir el riesgo asociado a complicaciones hemorrágicas durante su ciclo vital.
Métodos
Se realizó una revisión bibliográfica del tema, a través de diversas bases de datos en línea como Scielo, Dialnet, Pubmed, Elsevier. En donde se logró evidenciar que en la actualidad no hay presencia de artículos que abunden específicamente en el cuidado de enfermería a pacientes con diagnóstico de enfermedad de Von Willebrand. Razón por la cual se construyó el presente artículo a partir de la experiencia y teniendo en cuenta literatura médica en donde se aborda el concepto, diagnóstico y tratamiento de la enfermedad de Von Willebrand, punto de partida para establecer las intervenciones del plan de cuidados de enfermería.
Objetivo
Realizar una revisión sobre los aspectos esenciales para lograr una adecuada gestión de cuidado en los pacientes con diagnóstico de enfermedad de Von Willebrand.
Resultados
La percepción y definición de cuidado, es diferente de acuerdo con la apreciación y experiencia en el ámbito de cada profesional de enfermería, sin embargo, se presenta un punto en común frente a la necesidad de garantizar el mantenimiento de la salud y la prevención del riesgo a través de cada una de las intervenciones de cuidado propuestas.
Conclusiones
Para garantizar la gestión del cuidado idónea para los pacientes con diagnóstico de enfermedad de Von Willebrand, se requiere la elaboración por parte del profesional de enfermería de un plan de cuidados que esté principalmente enfocado en la valoración de patrones y análisis de cada una de las necesidades prioritarias, para de esta manera realizar adecuación de las intervenciones propuestas necesarias y así garantizar el mantenimiento de la salud y la prevención del riesgo asociado a su enfermedad.
The Relationship Between Atrial Fibrillation and Parathyroid Hormone in Heart Failure Outpatients
Authors: Murat Kerkutluoglu , Oguzhan Yucel , Hakan Gunes , Ufuk Ozgul , Birhan Yilmaz Mehmet 
Published: October 2023

Background Atrial fibrillation (AF) is a common arrhythmia in heart failure (HF). Plasma concentrations of para­thyroid hormone (PTH) have been shown to increase in HF. The relationship between PTH concentrations and the presence of AF in HF is, however, unknown. This study analyzed the relationship between plasma PHT concentrations and AF in patients with systolic HF.Material and methods 131 consecutive, stable HF patients, who were admitted to the HF outpatient clinic, were included in this prospective, observational study. Patients were classified as those with AF (n = 36) and those in sinus rhythm (SR, n = 95).Results PTH concentrations were markedly higher in patients with AF compared to the patients in SR [85 (15-320) vs. 112 (30-326) U / ml, p=0.007]. PTH, creatinine clearance, hemoglobin, creatinine, age, and left ventricular ejection fraction were found to be related to AF by univariate analysis; though, multivariate logistic regression analysis showed that only PTH concentration was independently related to AF.Conclusion PTH concentrations can be used to indicate AF in patients with systolic HF.
Imprensa e Insegurança Alimentar no Brasil da pandemia
Authors: Oliveira Natalia Bizerra , Freitas Brena Barbosa , Sousa Ana Cristina Augusto de 
Published: October 2023

Introdução: Este texto identifica e analisa matérias jornalísticas que abordaram o consumo de alimentos durante a pandemia, no contexto da crise econômica e do desmonte das políticas públicas de segurança alimentar no país. Objetivo: O objetivo geral do trabalho é analisar o conteúdo das matérias que abordaram o tema para perceber que mensagens elas transmitiam a respeito do agravamento da insegurança alimentar no contexto da crise econômica e do aumento do preço dos alimentos. Método: Para efetuar a análise do conteúdo, foram selecionadas 15 matérias nos sites de dois jornais, a saber, Extra e G1, do Grupo Globo S.A., publicadas entre 2020 e 2021, auge da pandemia. Resultados: Os resultados obtidos mostraram que, via de regra, a cobertura jornalística abordou o aumento do preço dos alimentos e dos custos na cadeia de suprimentos como uma realidade dada – às vezes, da natureza – e não como resultante de um processo construído politica e socialmente a partir das decisões políticas dos nossos dirigentes. Com isso, os verdadeiros responsáveis pela crise e pelo desmonte das políticas de segurança alimentar seguiram invisíveis e, portanto, protegidos da opinião pública. Discussão: O estudo examina de forma crítica o papel da mídia na produção de mensagens que perpetuam narrativas que ocultam os responsáveis pelos problemas coletivos da população e mostra, a partir da trajetória do setor, as decisões políticas que nos levaram de volta ao mapa da fome. Por fim, destaca a importância de reativar o CONSEA como órgão consultivo fundamental no combate à insegurança alimentar.
Modeling and Optimization of Mechanical Cutting of Downhole Tubing
Authors: Zhu Xiaohua , Zhou Bowen , Jing Jun , Shi Jiangmiao , Qin Ruyi 
Published: October 2023

SummaryMechanical cutting of tubing plays a vital role in solving the problem of pipe string jams in workover operations of oil wells. To improve the efficiency of downhole cutting operations and save operation costs, it is necessary to optimize the parameters of downhole-cutting operations. However, previous research did not involve related engineering problems. Therefore, in this paper, the equivalent simulation experiment of downhole cutting is conducted based on actual field data. Cutting speed, feed rate, and cutting thickness are used as parameters while cutting power (P), material removal rate (MRR), and tool chip temperature (T) are used as optimization objectives with the trade-offs between the three objectives considered. The full factorial design is used to carry out the experiments and the combination of grey relational analysis (GRA) method and entropy weight method is used to determine the weight of the three objectives. The influence of cutting parameters on the optimization objectives is analyzed, the mathematical model between cutting parameters and a single objective is established, and the adaptive weight particle swarm algorithm is used to optimize the coefficients of this model. The relationship between the multiobjective model and cutting parameters is established using a multiple nonlinear regression model, and the selection of interaction terms is completed using a stepwise regression method. The reliability of the model is also verified. This paper provides a reference for future research on downhole-cutting problems.
Prefrontal Cortical Regulation of REM Sleep
Authors: Weber Franz , Hong Jiso , Lozano David , Beier Kevin , Chung Shinjae 
Published: October 2023

Abstract
Rapid-eye-movement (REM) sleep is accompanied by intense cortical activity, underlying its wake-like electroencephalogram (EEG). The neural activity inducing REM sleep is thought to originate from subcortical circuits in brainstem and hypothalamus. However, whether cortical neurons can also trigger REM sleep has remained unknown. Here, we show in mice that the medial prefrontal cortex (mPFC) strongly promotes REM sleep. Bidirectional optogenetic manipulations demonstrate that excitatory mPFC neurons promote REM sleep through their projections to the lateral hypothalamus (LH) and regulate phasic events, reflected in accelerated EEG theta oscillations and increased eye-movement density during REM sleep. Calcium imaging reveals that the majority of LH-projecting mPFC neurons are maximally activated during REM sleep and a subpopulation is recruited during phasic theta accelerations. Our results delineate a cortico-hypothalamic circuit for the top-down control of REM sleep and identify a critical role of the mPFC in regulating phasic events during REM sleep.
On the maximum number of maximum independent sets of bipartite graphs
Authors: Sun Wanting , Li Shuchao 
Published: October 2023

Abstract

An independent set in a graph G is a set of pairwise non-adjacent vertices of G. The independence number, α, of G is the maximum cardinality of an independent set in G. An independent set in G is maximum if it has cardinality α. Mohr and Rautenbach determined the n-vertex trees (resp. disconnected graphs) with independence number α having the largest number of maximum independent sets. Quite recently, Mohr and Rautenbach characterized the connected graphs of order n and independence number α that maximize the number of maximum independent sets. As a continuance of these works, we characterize the bipartite graphs (containing at least one cycle) of order n and independence number α having the maximum number of maximum independent sets. Furthermore, we determine the n-vertex trees with independence number α having the second and third largest number of maximum independent sets. We also characterize the n-vertex forests with independence number α having the first three largest number of maximum independent sets. Among the n-vertex disconnected graphs with independence number α we identify the graphs with the second largest number of maximum independent sets. Our result gives a solution to an open problem of Derikvand and Oboudi [4], and we obtain a complete classification of connected graphs with order n and independence number n − 3.
AMS subject classification: 05C69, 05C35
New proposed of standard area diagram scale for assessing black sigatoka in bananas
Authors: Nuñez Andrés Mauricio Pinzón , Feria-Gómez Diego Felipe , Pérez-Ochoa Gloria Marcela , Arango-Palacio Laura , Rey-Valenzuela Vicente Emilio , Zapata-Henao Sebastián 
Published: October 2023

Abstract

Black sigatoka, or black leaf streak (BLS), is caused by Pseudocercospora fijiensis and is the most important foliar disease in Musa production. Our goal was to develop a new standard area diagram (SAD) with high-resolution digital images with six disease levels: 0 (0%), 1 (0.1–5.0%), 2 (5.01–13.0%), 3 (13.01–23.0%), 4 (23.01–40.0%), 5 (40.01–65.0%) and 6 (> 65.0%) and compare BLS severity results in banana leaves with those based on another SAD. Five evaluations were conducted by thirteen different evaluators and each evaluation was performed at seven-day intervals. The first assessment was done without a SADs. Evaluators performed two assessments with each SAD. The statistics were analyzed with linear regression and Lin’s concordance correlation. With the proposed SAD, the evaluators improved the precision, accuracy, repeatability and reproducibility and reduced the residual distribution, as compared using the other SAD. The proposed SAD is a tool that aids users in producing a disease estimate that is close to the real value of BLS in banana leaves.