bluuebunny/crossref_metadata_2025_split huggingface dataset:
Techno‐functional properties of dry‐fractionated plant‐based proteins and application in food product development: a review
Authors: De Angelis Davide , Latrofa Vittoria , Caponio Francesco , Pasqualone Antonella , Summo Carmine 
Published: November 2023

AbstractDry‐fractionated protein concentrates are gaining attention because they are produced using a versatile and sustainable technology, which can be applied to a wide range of plant material. To facilitate their utilization in new product development, it is crucial to obtain a comprehensive overview of their techno‐functional properties. The present review aims to examine the techno‐functional properties of dry‐fractionated protein concentrates and describe their primary applications in food products, considering the published works in the last decade. The techno‐functional properties of proteins, including water absorption capacity, emulsifying and foaming properties, gelling ability or protein solubility, are relevant factors to consider during food formulation. However, these properties are significantly influenced by the extraction technology, the type of protein and its characteristics. Overall, dry‐fractionated proteins are characterized by high protein solubility, high foaming ability and foam stability, and high gelling ability. Such properties have been exploited in the development of food, such as bakery products and pasta, with the aim of increasing the protein content and enhancing the nutritional value. Additionally, innovative foods with distinctive textural and nutritional characteristics, such as meat and dairy analogues, have been developed by using dry‐fractionated proteins. The results indicate that the study of these ingredients still needs to be improved, including their application with a broader range of plant materials. Nevertheless, this review could represent an initial step to obtaining an overview of the techno‐functional properties of dry‐fractionated proteins, facilitating their use in foods. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Soil properties following borrow pit reclamation with insufficient topsoil amended with peat and biochar
Authors: Nawu Takudzwa , Zvomuya Francis , Adesanya Theresa , Amarakoon Inoka , Bekele Asfaw 
Published: November 2023

AbstractDisturbed sites, such as borrow pits and oil and natural gas well sites, require reclamation to restore and sustain levels of productivity similar to those prior to the disturbance. However, salvaged topsoil at many sites is often insufficient to meet the 80% topsoil replacement depth (TRD80) required for successful reclamation in western Canada. This 5‐year study evaluated soil responses to 50% topsoil replacement depth without organic amendment (TRD50) or amended with either peat (PTRD50) or biochar (BTRD50), relative to the TRD80 treatment (Control), following borrow pit reclamation at a disturbed boreal site near Cold Lake, Alberta, Canada. Amendments were applied once at rates calculated to raise the soil organic carbon (SOC) content in the TRD50 soil to a level equal to that in the TRD80 treatment. Results showed a 143%, 87%, and 116% increase in total Kjeldahl nitrogen concentration in the PTRD50 relative to the TRD80, TRD50, and BTRD50 treatments, respectively, while soil potassium (K) concentration was significantly greater for BTRD50 than PTRD50. Peat and biochar significantly increased SOC concentrations by 83% and 88%, respectively, relative to the mean of TRD80 and TRD50 treatments. Our results show that peat and biochar can improve soil properties of disturbed boreal sites reclaimed with insufficient salvaged topsoil to a level suitable for successful reclamation. This has important implications on the reclamation of a multitude of disturbed sites, in Canada and globally, that have insufficient volumes of salvaged topsoil needed for successful reclamation.
An assessment of HgII to preserve carbonate system parameters in organic‐rich estuarine waters
Authors: Moore Christopher S. , Byrne Robert H. , Yates Kimberly K. 
Published: November 2023

AbstractThis work assesses the effectiveness of sample preservation techniques for measurements of pHT (total scale), total dissolved inorganic carbon (CT), and total alkalinity (AT) in organic‐rich estuarine waters as well as the internal consistency of measurements and calculations (e.g., AT, pHT, and CT) in these waters. Using mercuric chloride (HgCl2)‐treated and untreated water samples, measurements of these carbonate system parameters were examined over a period of 3 months. Respiration of dissolved organic matter in untreated samples created large discrepancies in CT concentrations (~37 μmol kg−1 increase, p < 0.0001), while CT was effectively constant in treated samples (3095.0 ± 1.14 μmol kg−1). AT changes were observed for both treated and untreated samples, with HgCl2‐treated samples showing the greatest variation (~ 26 μmol kg−1 decrease, p < 0.001). In response to changing AT/CT ratios, pHT changes occurred in both treated and untreated samples but were relatively small in treated samples. Results in organic‐rich estuarine waters that reflect the in situ carbonate system characteristics of the samples at the time of collection can be improved when samples obtained for CT and AT analysis are collected and stored separately. Accurate analyses of CT can be obtained by filtration and preservation with HgCl2. Accuracy of AT analyses can be improved by filtration and storage without adding HgCl2. The quality of pHT measurements can be improved by prompt analysis in the field and, if this cannot be accomplished, then samples can be preserved with HgCl2 and measured in the laboratory within 1 week.
Consuming for the authentic‐self: How exposure to death‐related information facilitates voluntary simplicity?
Authors: Liu Hongyan , Chen Yanxia , Liu Wumei 
Published: November 2023

AbstractDespite the growing prevalence of voluntary simplicity as a consumption value embraced by brands in recent years, limited research has empirically explored the antecedents of voluntary simplicity. This study addresses this research gap by investigating the impact of death‐related information on voluntary simplicity. Through five studies, we demonstrate that exposure to death‐related information increases voluntary simplicity (Studies 1, 2). This increase occurs because consumers exposed to death‐related information are motivated to pursue their authentic selves (Studies 3, 4). However, we further reveal that this effect disappears when the message appeal of death‐related information is emotional (Study 5). Our findings suggest that brands can implement communication strategies highlighting voluntary simplicity when consumers are exposed to death‐related information.
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras
Authors: Lu Xinchen , Jin Jinmei , Wu Ye , Liu Xiaoxia , Liang Xiaohui , Lin Jiayi , Sun Qingyan , Qin Jiangjiang , Zhang Weidong , Luan Xin 
Published: November 2023

AbstractAs a widely considerable target in chemical biology and pharmacological research, rat sarcoma (RAS) gene mutations play a critical driving factor in several fatal cancers. Despite the great progress of RAS subtype‐specific inhibitors, rapid acquired drug resistance could limit their further clinical applications. Proteolysis targeting chimera (PROTAC) has emerged as a powerful tool to handle “undruggable” targets and exhibited significant therapeutic benefit for the combat of drug resistance. Owing to unique molecular mechanism and binding kinetics, PROTAC is expected to become a feasible strategy to break the bottleneck of classical RAS inhibitors. This review aims to discuss the current advances of RAS inhibitors and especially focus on PROTAC strategy targeting RAS mutations and their downstream effectors for relevant cancer treatment.
The relationship between volunteer management, satisfaction, and intention to continue volunteering in sport events: An environmental psychology perspective
Authors: Chiu Weisheng , Kang Hyoung‐Kil , Cho Heetae 
Published: November 2023

AbstractThis study aimed to investigate the relationship between volunteer management, motivation, satisfaction, and continuance intention to volunteer through the lens of Mehrabian and Russell's (1974) environmental psychology model. Moreover, the moderating effect of the volunteer experience was examined in the relationships between constructs. Data were collected from volunteers participating in various sport events in Singapore (N = 290). Results showed volunteer management positively influenced volunteers' satisfaction, which in turn affected their continuance intention. Moreover, motivation had a positive impact on both satisfaction and continuance intention. In addition, the moderating role of volunteer experience was identified. Based on Mehrabian and Russell's (1974) environmental psychology model, the findings of this study offered an alternative perspective on volunteers' satisfaction and continuance intention and provided insights into specific groups of volunteers.
Predicting the Outcomes of Oropharyngeal Surgery in Patients With Obstructive Sleep Apnea Using Tongue‐Retaining Devices
Authors: Yeh Peng , Huang Tsung‐Wei 
Published: November 2023

AbstractObjectiveTo determine the efficacy of a tongue‐retaining device (TRD) in predicting the outcomes of oropharyngeal surgery in patients with obstructive sleep apnea (OSA) before surgery.Study DesignA prospective case‐control study.SettingA single tertiary medical center.MethodsPatients with moderate‐severe OSA who underwent both uvulopalatopharyngoplasty and tongue base suspension between January 2022 and July 2022 were included. Each patient underwent a series of 3 overnight polysomnography. Objective outcomes include apnea‐hypopnea index (AHI), minimal oxygen saturation, and reduction rate of AHI. The correlation between the reduction rate of AHI with TRD and surgery was analyzed with linear regression.ResultsThe reduction rates of AHI were significantly different between the group using TRD (44 ± 24%) and the postoperative group (55 ± 21%). The cross‐tabulation revealed a strong association between a positive response to TRD treatment and a positive response to surgery. The use of TRD to evaluate surgical response demonstrated a positive predictive value of 90% and a negative predictive value of 70%. A strong correlation between the decrease in AHI was observed in both TRD and surgery groups, which was demonstrated by a steep slope in the scatter plot and a significant simple linear regression line.ConclusionPreoperative TRD response is an accurate tool for predicting the success of oropharyngeal surgery in managing OSA patients before surgical treatment. Furthermore, a quantifiable positive linear correlation exists between the efficacy of preoperative TRD treatment and surgery.
Language Patterns in Letters of Recommendation for Residency Applicants in Otolaryngology
Authors: Campbell James C. , Canick Julia E. , Redmond Rebecca , Lee Janet W. , Woodard Charles R. , Grimm Lars J. 
Published: November 2023

AbstractObjectiveAssess for gender and race patterns in agentic and communal language used in letters of recommendation for Otolaryngology–Head and Neck Surgery (OHNS) residency applicants.Study DesignRetrospective content analysis.SettingApplications from OHNS applications at a single training institution for the 2019 and 2020 match cycles.MethodsA total of 2283 letters of recommendation for 611 OHNS applicants were analyzed. Applicant and letter writer gender, applicant race and ethnicity, and applicant characteristics including United States Medical Licensing Examination® Step 1 score, research productivity, and medical school rank were extracted. Agentic and communal word use from the letters of recommendation was compared across applicant and writer characteristics using multilevel negative binomial regression modeling.ResultsLetter writers use a greater rate of agentic terms when describing applicants who self‐identify as Asian (incidence rate ratio [IRR] = 1.16, p < .01) or “Other/not reported” (IRR = 1.23, p < .01) as compared to white applicants. Further, standardized letters of evaluation had significantly more communal language and less agentic language. Although there was an increase in communal language in letters for female applicants compared to male applicants, these gender differences disappeared in the multivariate model.ConclusionMultivariate analysis demonstrated no significant gender‐based patterns in the communal or agentic language in letters of recommendation for OHNS residency applicants. However, letters for applicants identifying as Asian or “other/not reported” had more frequent use of agentic terms. Future studies should investigate other components of residency applications to assess how gender and race bias might unfairly influence an applicant's chances at a given program.
Integrating multi‐index determination coupled with hierarchical cluster analysis to evaluate the quality consistency of PVE30, an anti‐HSV “glycoprotein” macromolecule of Prunellae Spica
Authors: Luo Xiaomei , Yuan Man , Lu Ping , Zhong Xuanlei , Zhang Yibo , Li Yang , Xi Zhichao , Zhang Hongmei , Li Songlin , Xu Hongxi 
Published: November 2023

AbstractIntroductionPrunellae Spica (PS), derived from the dried fruit spikes of Prunella vulgaris L., is a traditional Chinese medicinal herb. Our previous studies found that PVE30, a water‐extracting ethanol‐precipitating “glycoprotein” macromolecule of PS, was a potential anti‐herpes simplex virus (HSV) candidate. However, due to the complex structure and diverse bioactivity of the “glycoprotein”, ensuring its quality consistency across different batches of PVE30 becomes particularly challenging. This poses a significant hurdle for new drug development based on PVE30.ObjectiveOur study aimed to integrate multi‐index determination coupled with hierarchical cluster analysis (HCA) to holistically profile the quality consistency of “glycoprotein” in PVE30.MethodsHigh‐performance gel permeation chromatography with refractive index detector (HPGPC‐RID) was used to characterise the molecular weight (Mw) distribution, HPLC‐PDA was used to quantitatively analyse the composed monosaccharides and amino acids, and UV‐VIS was used to quantify the contents of polysaccharides and proteins. Qualitative and quantitative consistency was analysed for each single index in 16 batches of PVE30, and a 16 × 38 data matrix, coupled with HCA, was used to evaluate the holistic quality consistency of PVE30.ResultsThe newly developed and validated methods were exclusive, linear, precise, accurate, and stable enough to quantify multi‐indexes in PVE30. Single‐index analysis revealed that 16 batches of PVE30 were qualitatively consistent in Mw distribution, polysaccharides and proteins, and the composition of composed monosaccharides and amino acids but quantitatively inconsistent in the relative contents of some “glycoprotein” macromolecules, as well as the composed monosaccharides/amino acids. HCA showed that the holistic quality of PVE30 was inconsistent, the inconsistency was uncorrelated with the regions where PS was commercially collected, and the contents of 17 amino acids and 2 monosaccharides contributed most to the holistic quality inconsistency.ConclusionMulti‐index determination coupled with HCA was successful in evaluating the quality consistency of PVE30, and the significant difference in quantitative indices was not caused by the origin of PS. The cultivating basis should be confirmed for PVE30‐based new drug development.
Development and validation of a novel fetal vesico‐amniotic shunt, the vortex shunt
Authors: Blumenfeld Yair J. , Sheth Kunj R. , Johnson Eric , Wall James K. , Deprest Jan A. , Russo Francesca M. , Danzer Enrico 
Published: November 2023

AbstractFetal lower urinary tract obstruction (LUTO) is a severe malformation associated with an up to 80% mortality risk as well as significant renal and pulmonary morbidity in survivors. Fetal vesico‐amniotic shunts (VAS) bypass the bladder obstruction, improve amniotic fluid volume and enhance in‐utero pulmonary development. VAS has been shown to reduce respiratory morbidity and mortality in the neonatal period without proven benefit on long‐term renal and bladder function. Clinically available shunts are associated with an up to 80% dislodgement rate, leading to repeat invasive procedures which increase fetal and maternal risks. We developed a novel “Vortex” shunt, which incorporates enhanced fixation to reduce dislodgement, a one‐way valve to optimize in‐utero bladder function, and enhanced sonographic echogenicity that optimizes the accurate deployment. Following the validation of these characteristics in initial benchtop experiments we have moved to feasibility studies in the fetal lamb model. We hope that the Vortex shunt may ultimately facilitate shunt deployment, reduce dislodgement risk, improve neonatal morbidity and mortality, and decrease the significant healthcare expenditures associated with long‐term morbidity in LUTO survivors. In this manuscript, we review the natural history of LUTO, the risks and benefits of clinically available fetal shunts, and our development and early validation experiments.
Computational phenotyping within electronic healthcare data to identify transgender people in the United States: A narrative review
Authors: Beltran Theo G. , Lett Elle , Poteat Tonia , Hincapie‐Castillo Juan M. 
Published: November 2023

AbstractPurposeWith the expansion of research utilizing electronic healthcare data to identify transgender (TG) population health trends, the validity of computational phenotype (CP) algorithms to identify TG patients is not well understood. We aim to identify the current state of the literature that has utilized CPs to identify TG people within electronic healthcare data and their validity, potential gaps, and a synthesis of future recommendations based on past studies.MethodsAuthors searched the National Library of Medicine's PubMed, Scopus, and the American Psychological Association PsycInfo's databases to identify studies published in the United States that applied CPs to identify TG people within electronic healthcare data.ResultsTwelve studies were able to validate or enhance the positive predictive value (PPV) of their CP through manual chart reviews (n = 5), hierarchy of code mechanisms (n = 4), key text‐strings (n = 2), or self‐surveys (n = 1). CPs with the highest PPV to identify TG patients within their study population contained diagnosis codes and other components such as key text‐strings. However, if key text‐strings were not available, researchers have been able to find most TG patients within their electronic healthcare databases through diagnosis codes alone.ConclusionCPs with the highest accuracy to identify TG patients contained diagnosis codes along with components such as procedural codes or key text‐strings. CPs with high validity are essential to identifying TG patients when self‐reported gender identity is not available. Still, self‐reported gender identity information should be collected within electronic healthcare data as it is the gold standard method to better understand TG population health patterns.
Neuer Blick auf die Bildung des Sonnensystems
Authors: Altwegg Kathrin , Rubin Martin 
Published: November 2023

ZusammenfassungAuch wenn sieben Jahre nach Ende der Rosetta‐Mission die Datenanalyse noch nicht beendet ist, haben die bisherigen Resultate die Vorstellung, dass Kometen primitive Körper sind, die hauptsächlich aus Wasser, CO und CO2 bestehen, klar widerlegt. Die chemischen und physikalischen Eigenschaften des Kometen lassen auf eine sanfte Agglomeration in einer kalten Umgebung schließen, wobei viele der Moleküle einen präsolaren Ursprung haben, insbesondere auch Wasser. Die chemische Zusammensetzung eines Kometen ist höchst komplex. Darunter sind etliche präbiotische Moleküle, die die These stützen, dass Kometeneinschläge möglicherweise die Entstehung des Lebens auf der Erde befördert haben.
Cell wall‐localized Bt protein endows rice high resistance to Lepidoptera pests
Authors: Li Hua , Deng Lihua , Weng Lvshui , Li Jinjiang , Hu Wenbin , Yu Jianghui , Xiao Youlun , Xiao Guoying 
Published: November 2023

AbstractBACKGROUNDThe commercialized Bt (Bacillus thuringiensis) crops accumulate Bt protein within cells, but the intracellular interactions of foreign protein with endogenous protein inevitably result in large or small unintended effects. In this study, the Bt gene Cry1Ca was linked with the sequences of extracellular secretion signal peptide and carbohydrate binding module 11 to constitute a fusion gene SP‐Cry1Ca‐CBM11, and the fusion gene driven by constitutive promoters was used for secreting and anchoring onto the cell wall to minimize unintended effects.RESULTSThe transient expression in tobacco leaves demonstrated that the fusion protein was anchored on cell walls. The Cry1Ca contents of five homozygous rice transformants of single‐copy insertion were different and descended in the order leaf > root > stem. The maximum content of Cry1Ca was 17.55 μg g−1 in leaves of transformant 21H037. The bioassay results revealed that the transformants exhibited high resistance to lepidopteran pests. The corrected mortality of pink stem borer (Sesamia inferens) and striped stem borer (Chilo suppressalis) ranged from 96.33% to 100%, and from 83.32% to 100%, respectively, and the corrected mortality of rice leaf roller (Cnaphalocrocis medinalis) was 92.53%. Besides, the agronomic traits of the five transformants were normal and similar to that of the recipient, and the transformants were highly resistant to glyphosate at the germination and seedling stages.CONCLUSIONThe fusion Bt protein was accumulated on cell walls and endowed the rice with high resistance to lepidopteran pests without unintended effects in agronomic traits. © 2023 Society of Chemical Industry.
Excitation‐Selective and Double‐Emissive Lead‐Free Binary Hybrid Metal Halides for White Light‐Emitting Diode and X‐Ray Scintillation
Authors: Ju Dianxing , Zhou Ming , Liu Zhichao , Ran Peng , Dong Zhiwen , Hou Shuo , Li Hao , Xiao Wenge , Xu Xuhui , Li Huifang , Yang Yang (Michael) , Jiang Tingming 
Published: November 2023

AbstractZero‐dimensional (0D) organic metal halides comprising heterogeneous metal cations in single phase can achieve multiple luminous emissions enabling them toward multifunctional light‐emitting applications. Herein, A novel single crystal of (C8H20N)4SbMnCl9 containing two luminescent centers of [SbCl5]2− pentahedrons and [MnCl4]2− tetrahedrons is reported. The large distance between Sb–Sb, Mn–Mn, and Sb–Mn as well as theory calculation indicate negligible interaction between individual centers, thus endowing (C8H20N)4SbMnCl9 with excitation‐dependable and efficient luminescence. Under near‐UV excitation, only orange emission originates from self‐trapped excitons recombination in [SbCl5]2− pentahedron occurs with photoluminescence quantum yield (PLQY) of 91.5%. Under blue‐light excitation, only green emission originating from 4T1‐6A1 transition of Mn2+ in [MnCl4]2− tetrahedrons occurs with PLQY of 66.8%. Interestingly, upon X‐ray illumination, both emissions can be fully achieved due to the high‐energy photon absorption. Consequently, (C8H20N)4SbMnCl9 is employed as phosphors to fabricate white light‐emitting diodes optically pumped by n‐UV chip and blue‐chip thanks to its excitation‐dependable property. Moreover, it also shows promising performance as X‐ray scintillator with low detection limit of 60.79 nGyair S−1, steady‐state light yield ≈54% of commerical scintillaotr LuAG:Ce, high resolution of 13.5 lp mm−1 for X‐ray imaging. This work presents a new structural design to fabricate 0D hybrids with multicolor emissions.