bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KOMUNIKASI INTERPERSONAL PIALANG DAN KEPERCAYAAN TERHADAP KEPUASAN INVESTOR PADA PT. KONTAK PERKASA FUTURES
Authors: Nurani Ni Nyoman , Santoso Indah Apriliyani 
Published: December 2023

The purpose of this study was to determine the effect of broker interpersonal communication and trust in investor satisfaction at PT. Mighty Contact Futures. The population in this study are all investors of PT. Contact Mighty Future. The sampling technique used in this study was a sampling quota of 30 people. The type of data used is quantitative data and qualitative data. The data source used is primary data. Data collection techniques are observation, questionnaire and documentation. Data analysis techniques using multiple linear regression analysis, correlation analysis and determination analysis. The results showed interpersonal communication has a positive and significant effect on investor satisfaction at PT. Contact Mighty Bali Futures. Trust has a positive and significant effect on investor satisfaction at PT. Contact Mighty Bali Futures. There is a significant influence of interpersonal communication and trust together on investor satisfaction at PT. Contact Mighty Bali Futures. The magnitude of the influence of interpersonal communication and trust on investor satisfaction at PT. Bali Mighty Futures Contact is 57.3%.
PENGARUH BAHAN BAKU DAN TEKNIK PEWARNAAN TERHADAP VARIABEL KEUANGAN SOUVENIR BARONG PADA BTIKK
Authors: Normal I Nyoman 
Published: December 2023

The aims of this research was to determine the effect of changes in raw materials and coloring techniques on the financial variables of biscuit-baked barong souvenirs at BTIKK in 2019. This research method is descriptive quantitative, which data sources are internal and external, both primary and secondary. The analysis techniques are: a standard cost system based on full costing to calculate the cost of goods manufactured, cost-plus pricing to calculate the selling price, and the operating profit margin method to calculate profitability. The results showed that the change in raw material from CN-17 cast mass to BPN-01 cast mass and the coloring technique from underglaze to onglaze could increase financial variables (cost of goods manufactured, selling price, and operating profit margin) of biscuit-baked barong souvenir (l30,0 - w10,0 - h25,0). The effect on the cost of goods manufactured of barong souvenir made of CN-17 mass raw material for underglaze staining, BPN-01 cast mass raw material under underglaze staining, CN-17 cast mass raw material onglaze staining, and BPN-01 cast mass raw material for onglaze staining are increasing respectively 548.76%, 553.64%, 563.88%, and 568.67% respectively compared to biscuit-baked barong souvenir, because changes in raw materials and / or coloring techniques change the composition and types of raw materials which cost more expensive, time processing takes longer, the cost of colour material is more expensive, and the frequency of burning is increased by two or three times.
KUALITAS PELAYANAN DAN PROMOSI PENGARUHNYA TERHADAP KEPUASAN PELANGGAN PADA AGROWISATA LEBAH ETNO BALI FOUNDATION DI DESA BAHA MENGWI
Authors: Komang Juniasih Ida Ayu , Radendra Suastama Ida Bagus , Oka Dharma Putu Dananjaya 
Published: December 2023

Agrotourism is an activity related to tourism activities which is also a lesson for tourists to get to know more about the production process in the agricultural sector and make the agricultural area a place to enjoy agricultural products directly. The purpose of the study was to determine the effect of service quality and promotion on customer satisfaction at the Bali Foundation's Ethno Bees Agrotourism. The types of data used in this study are qualitative data and quantitative data, with data sources namely primary data and secondary data. Methods of collecting data by means of observation, interviews, documentation and questionnaires. The results showed that there was a positive and significant influence between service quality and promotion on customer satisfaction, which means that the higher the service and promotion quality, the higher the customer satisfaction. In this case, every improvement in service quality and promotion will increase customer satisfaction. In addition, there is a positive and significant influence between service quality and promotion simultaneously on customer satisfaction at the Bali Foundation's Ethno Bee Agrotourism in Baha Mengwi Village.
Qualidade de vida em adultos com transtorno déficit de atenção e hiperatividade
Authors: Batista Von Borowski Sílvia , Da Silva Rizzatti Letícia , Machado Lopes Fernanda 
Published: December 2023

O Transtorno de Déficit de Atenção e Hiperatividade (TDAH) afeta, além de crianças, muitos adultos. Gera grande impacto na vida desses indivíduos, resultando em dificuldades acadêmicas, profissionais, sociais e emocionais. O objetivo deste estudo foi descrever os níveis de qualidade de vida (QV) em brasileiros diagnosticados com TDAH em acompanhamento psicoterapêutico e/ou farmacológico. Participaram 106 adultos, os quais responderam um questionário sociodemográfico e à Escala de Satisfação com a Vida WHOQOL – Bref. O perfil sociodemográfico dos participantes deste estudo, contrário à maior parte da literatura, foi de pessoas com alta escolaridade e empregadas. Apesar disso, a maioria deles percebe seu nível de QV como baixo, pois 40,6% referiu que está regular e 28,3% que precisa melhorar, comparado com os que percebem como bom (29,2%) ou muito bom (1,9%). Tal constatação suscita a discussão sobre a eficácia e efetividade do tratamento e o alinhamento deste com os valores e metas dos pacientes. Recomenda-se que os profissionais de saúde atentem para o custo emocional nos processos de manutenção de rotinas, trabalho e expectativas de bem-estar dos pacientes. Além disso, que façam uma avaliação periódica dos déficits e potencialidades para um plano de tratamento direcionado às características e necessidades que suscitem melhor percepção de QV por parte dos indivíduos com TDAH.
Pharmacoscreening, molecular dynamics, and quantum mechanics of inermin from Panax ginseng: a crucial molecule inhibiting exosomal protein target associated with coronary artery disease progression
Authors: V Janakiraman , M Sudhan , Wani Abubakar , Ahmad Sheikh F. , Nadeem Ahmed , Sharma Ashutosh , Ahmed Shiek S. S. J. 
Published: December 2023

Background
Exosomes, microvesicles, carry and release several vital molecules across cells, tissues, and organs. Epicardial adipose tissue exosomes are critical in the development and progression of coronary artery disease (CAD). It is hypothesized that exosomes may transport causative molecules from inflamed tissue and deliver to the target tissue and progress CAD. Thus, identifying and inhibiting the CAD-associated proteins that are being transported to other cells via exosomes will help slow the progression of CAD.

Methods
This study uses a systems biological approach that integrates differential gene expression in the CAD, exosomal cargo assessment, protein network construction, and functional enrichment to identify the crucial exosomal cargo protein target. Meanwhile, absorption, distribution, metabolism, and excretion (ADME) screening of Panax ginseng-derived compounds was conducted and then docked against the protein target to identify potential inhibitors and then subjected to molecular dynamics simulation (MDS) to understand the behavior of the protein-ligand complex till 100 nanoseconds. Finally, density functional theory (DFT) calculation was performed on the ligand with the highest affinity with the target.

Results
Through the systems biological approach, Mothers against decapentaplegic homolog 2 protein (SMAD2) was determined as a potential target that linked with PI3K-Akt signaling, Ubiquitin mediated proteolysis, and the focal adhesion pathway. Further, screening of 190 Panax ginseng compounds, 27 showed drug-likeness properties. Inermin, a phytochemical showed good docking with −5.02 kcal/mol and achieved stability confirmation with SMAD2 based on MDS when compared to the known CAD drugs. Additionally, DFT analysis of inermin showed high chemical activity that significantly contributes to effective target binding. Overall, our computational study suggests that inermin could act against SMAD2 and may aid in the management of CAD.
Incorporation of Technology in the Mathematics Classroom: A Review of its Extent in Ghana's Educational Landscape
Authors: Atteh Evans , Boadi Augustine , Amoah Esther 
Published: December 2023

In the early stages, humans exhibited apprehension towards interacting with computers, however presently, the majority of individuals possess the ability to effectively utilize computers and their associated functionalities. The incorporation of technology in the field of mathematics extends beyond basic tasks such as typing and printing questions or delivering courses using PowerPoint. Instead, it involves utilizing technology to effectively educate learners on a wide range of mathematical concepts and topics. The incorporation of technology in mathematics education yields beneficial outcomes for both the instruction and acquisition of mathematical concepts. Hence, it is imperative for educators in the field of mathematics to include technology into their instructional practices, while also fostering a culture that promotes the utilization of technology by students for the purpose of enhancing their mathematical learning experiences The aim of the paper is to draw attention to existing literature that examines the integration of technology in math classrooms in Ghana, including the available technologies, their use for teaching math, the competence of math teachers in integrating technology, the relationship between the mathematics curriculum and technology integration, the benefits of technology in developing math concepts, the challenges of teaching with technology, and the implications of incorporating technology in math education.
Engineering Ultra‐Small Cerium‐Based Metal–Organic Frameworks Nanozymes for Efficient Antioxidative Treatment of Dry Eye Disease
Authors: Chen Zhongxing , Li Zheng , Tang Nana , Huang Yida , Li Siheng , Xu Wenjin , Wang Qing , Chen Xin , Zhao Nan , Zeng Zhenhai , Xiao Yichen , Chen Xinyi , Li Jiawei , Zhou Xingtao , Li Guisheng , Yang Mei , Huang Jinhai 
Published: December 2023

AbstractDry eye disease (DED) is a widespread ophthalmic illness that inflicts massive economic and medical burdens on society. Although oxidative stress is closely associated with the onset of DED, barely any quantities of antioxidants are clinically available owing to low efficiency, toxicity, and poor bioavailability. Cerium‐based nanozymes possess promising enzyme‐mimetic activities in scavenging reactive oxygen species (ROS). Moreover, the ultra‐small metal–organic frameworks (MOFs) have the potential for more efficient drug delivery, ROS elimination, and therapeutic efficacy. However, the development of ultra‐small cerium‐based MOFs (Ce‐MOFs) is limited to a small minority due to challenges in the synthetic process and stability. By simply adjusting raw ingredients concentrations, three types of Ce‐MOFs with distinct particle sizes are synthesized: Ce‐MOF 1 (213 nm), Ce‐MOF 2 (36 nm), and Ce‐MOF 3 (2 nm). In comparison, the obtained ultra‐small Ce‐MOF 3 exhibited superior ROS scavenging and antioxidant capacity, decreased cytotoxicity, and excellent ocular penetration. Therapeutically, Ce‐MOF 3 is demonstrated to be highly efficient in alleviating DED by suppressing oxidative stress and inflammation, boosting corneal epithelial repair, and facilitating tear secretion recovery. The novel ultra‐small Ce‐MOF 3 may serve as a promising alternative treatment for DED and other ROS‐related disorders when combined with ocular biocompatibility.
Towel‐Inspired Fabric‐Based Evaporator for Highly Efficient Water‐Evaporation Desalination
Authors: Li Jiugang , Ge Can , He Jiahao , Jin Xinpeng , He Chong , Liu Keshuai , Xu Duo , Li Wenbin 
Published: December 2023

AbstractSolar‐driven interfacial evaporation is an environmentally friendly and sustainable freshwater‐production technology with substantial market potential. Nonetheless, it encounters significant challenges related to energy‐conversion efficiency and resistance to salt crystallization. Thus, a towel‐inspired fabric‐based evaporator (TFE) containing various functional layers using carbon and cotton‐polyester‐blended fibers is designed and woven. The surface of the TFE is woven into a towel‐ring structure, which affords a high sunlight‐contact area and a superior sunlight absorption rate of 96.2%. In contrast, the hydrophilic layer at the bottom of the TFE delivers superior water‐molecule storage and conduction due to its multilayer corner‐interlocking fabric structure. Compared to commercial fabric‐based evaporators, the loop structure of the towel fabric enables water molecules to flow rapidly under the influence of wind, which effectively enhances the evaporation rate of the TFE. The optimal TFE can reach a high water‐evaporation rate of 3.72 kg m−2 h−1 under 1 kW m−2 sunlight and a wind speed of 2 m s−1, which is ascribable to sunlight/wind synergy. No precipitated salt is detected on the TFE surface after continuously evaporating a 3.5 wt.% NaCl solution for 8 h. These exceptional attributes position the TFE as a highly suitable candidate for diverse seawater desalination applications.
Synthesis of Chiral 2‐Oxazolidinones by Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation of 2‐Oxazolones
Authors: Yu Pinke , Chen Danyi , Liu Yiwen , Yin Congcong , Liu Qixing , Zhou Haifeng 
Published: December 2023

AbstractAn asymmetric transfer hydrogenation of 2‐oxazolones in the presence of a chiral diamine ruthenium catalyst with potassium formate as a hydrogen source and potassium carbonate as an additive in 2,2,2‐trifluoroethanol is described. A series of chiral 2‐oxazolidinones were obtained with 29%–95% yields and 86%–>99% ee's. Furthermore, gram‐scale synthesis of chiral 2‐oxazolidinone and its downstream derivatizations demonstrate the practicality of this method.
Electrochemical‐induced 1,3‐oxohydroxylation of arylcyclopropanes
Authors: Huang Xuejin , Cai Jianhua , Zheng Ye , Song Chunlan , Li Jiakun 
Published: December 2023

AbstractHerein, we present a method for electrochemical‐induced 1,3‐oxohydroxylation of arylcyclopropanes with H2O as the green oxygen source. This transformation offers a regioselective route to highly functionalized β‐hydroxy ketones under oxidant‐ and metal‐free conditions. Notably, this electrochemical approach features simple operation, good regioselectivity, high functional group tolerance, and easy derivatization of the products. Mechanistic studies have provided solid evidences that 1,3‐diol acts as the crucial intermediate in this reaction, leading to the observed regioselectivity.
Improving the Accuracy of Robot Collecting Organisms in Marine Environment Based on Yolov5 Improvement
Authors: Wang Shengwei , Yuan Zhongjie , Wang Haizhen , Wen Yongqin 
Published: December 2023

AbstractIn this paper, an improved YOLOv5 multiscale marine organism target detection algorithm (YOLOv5‐Mult) is proposed to address the insufficient feature extraction ability of small targets, low detection accuracy, and high catching error of existing models in complex environments. First, real frame clustering is performed using the Kmeans++ method. Second, the BiFPN network module is adopted in lieu of the PANet network module to enhance the feature fusion ability. Next, the multilayer semantic fusion module RBC (RepBlock CSP) replaces the C3 module before the SPP layer of the Backbone network and the C3 module in the Neck layer to enrich the image semantic information. Finally, the multiscale feature fusion module MC (Mult Conv) replaces the last C3 module in the Backbone network to mitigate the semantic gap between different feature channel layers. Experimental results demonstrate that the improved algorithm attains a mAP value of 71.18%, which is 5.22% higher than that of the original YOLOv5 algorithm, providing accurate identification and fishing for underwater robots.
Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles
Authors: Fernandes Soraia , Cassani Marco , Cavalieri Francesca , Forte Giancarlo , Caruso Frank 
Published: December 2023

AbstractThe application of lipid‐based nanoparticles for COVID‐19 vaccines and transthyretin‐mediated amyloidosis treatment have highlighted their potential for translation to cancer therapy. However, their use in delivering drugs to solid tumors is limited by ineffective targeting, heterogeneous organ distribution, systemic inflammatory responses, and insufficient drug accumulation at the tumor. Instead, the use of lipid‐based nanoparticles to remotely activate immune system responses is an emerging effective strategy. Despite this approach showing potential for treating hematological cancers, its application to treat solid tumors is hampered by the selection of eligible targets, tumor heterogeneity, and ineffective penetration of activated T cells within the tumor. Notwithstanding, the use of lipid‐based nanoparticles for immunotherapy is projected to revolutionize cancer therapy, with the ultimate goal of rendering cancer a chronic disease. However, the translational success is likely to depend on the use of predictive tumor models in preclinical studies, simulating the complexity of the tumor microenvironment (e.g., the fibrotic extracellular matrix that impairs therapeutic outcomes) and stimulating tumor progression. This review compiles recent advances in the field of antitumor lipid‐based nanoparticles and highlights emerging therapeutic approaches (e.g., mechanotherapy) to modulate tumor stiffness and improve T cell infiltration, and the use of organoids to better guide therapeutic outcomes.
Second Coordination Sphere Effect Shifts CO2 to CO Reduction by Iron Porphyrin from Fe0 to FeI
Authors: Amanullah Sk , Gotico Philipp , Sircoglou Marie , Leibl Winfried , Llansola‐Portoles Manuel J. , Tibiletti Tania , Quaranta Annamaria , Halime Zakaria , Aukauloo Ally 
Published: December 2023

AbstractIron porphyrins are among the most studied molecular catalysts for carbon dioxide (CO2) reduction and their reactivity is constantly being enhanced through the implementation of chemical functionalities in the second coordination sphere inspired by the active sites of enzymes. In this study, we were intrigued to observe that a multipoint hydrogen bonding scheme provided by embarked urea groups could also shift the redox activation step of CO2 from the well‐admitted Fe(0) to the Fe(I) state. Using EPR, resonance Raman, IR and UV‐Visible spectroscopies, we underpinned a two‐electron activation step of CO2 starting from the Fe(I) oxidation state to form, after protonation, an Fe(III)−COOH species. The addition of another electron and a proton to the latter species converged to the cleavage of a C−O bond with the loss of water molecule resulting in an Fe(II)−CO species. DFT analyses of these postulated intermediates are in good agreement with our collected spectroscopic data, allowing us to propose an alternative pathway in the catalytic CO2 reduction with iron porphyrin catalyst. Such a remarkable shift opens new lines of research in the design of molecular catalysts to reach low overpotentials in performing multi‐electronic CO2 reduction catalysis.
A Raman spectral marker for the iso‐octyl chain structure of cholesterol
Authors: Simeral Mathieu L. , Demers Steven M. E. , Sheth Kyle , Hafner Jason H. 
Published: December 2023

AbstractRaman spectroscopy provides label‐free, specific analysis of biomolecular structure and interactions. It could have a greater impact with improved characterization of complex fingerprint vibrations. Many Raman peaks have been assigned to cholesterol, for example, but the molecular vibrations associated with those peaks are not known. In this report, time‐dependent density functional theory calculations of the Raman spectrum of cholesterol are compared to measurements on microcrystalline powder to identify 23 peaks in the Raman spectrum. Among them, a band of six peaks is found to be sensitive to the conformational structure of cholesterol's iso‐octyl chain. Calculations on 10 conformers in this spectral band are fit to experimental spectra to probe the cholesterol chain structure in purified powder and in phospholipid vesicles. In vesicles, the chain is found to bend perpendicular to the steroid rings, supporting the case that the chain is a dynamic structure that contributes to lipid condensation and other effects of cholesterol in biomembranes.Statement of Significance: Here we use density functional theory to identify a band of six peaks in cholesterol's Raman spectrum that is sensitive to the conformational structure of cholesterol's chain. Raman spectra were analyzed to show that in fluid‐phase lipid membranes, about half of the cholesterol chains point perpendicular to the steroid rings. This new method of label‐free structural analysis could make significant contributions to our understanding of cholesterol's critical role in biomembrane structure and function. More broadly, the results show that computational quantum chemistry Raman spectroscopy can make significant new contributions to molecular structure when spectra are interpreted with computational quantum chemistry.
Atomic force microscopy and scanning electron microscopy characterization of the controlling of surface morphology of epoxy‐amine‐cured spin‐coated films
Authors: Shenk Timothy M. , Benjamin Kenneth M. , Winter Robb M. 
Published: December 2023

AbstractAtomic force microscopy (AFM) was successfully used to study spin‐coated, amine‐cured epoxy film microstructure and morphology. The air‐epoxy and epoxy‐substrate interfaces were examined using tapping‐mode height and phase imaging AFM. The impact of relative humidity on the morphology and microstructure of the surfaces was determined. AFM was able to elucidate the changes on the surface as relative humidity during processing increased. It was observed that large nodular formations formed on the epoxy surface expose to the air but not epoxy surface formed on the substrate in addition to varying regions of more or less compliant structures, which was attributed to carbamate formation caused by the amine curing agent reaction with atmospheric CO2. Scanning electron microscopy (SEM) was used to further elucidate interface and interphase morphology of spin‐coated epoxies. Experimentation also demonstrated that post‐curing above the glass transition did not change the morphology structure, suggesting surface structures are “locked‐in.” SEM was used to further elucidate how the interface and interphase change with changing environmental conditions at both the air‐epoxy and epoxy‐substrate interface/interphases, including the impact of atmospheric CO2 on Marangoni cell formation.
Syntheses of Iminophosphomamido Chlorogermylenes and Their Complexation with a Rhodium(I) Complex
Authors: Takahashi Shintaro , Kamiyama Shota , Ishii Akihiko , Nakata Norio 
Published: December 2023

AbstractThree‐coordinated chlorogermylenes of the type [Ph2P(RN)2]GeCl (3: R=tBu; 4: R=Dip=2,6‐iPr2C6H3), which bear an N,N‐substituted iminophosphonamide ligand, were synthesized. The coordination behavior of 3 and 4 toward rhodium(I) complex was investigated. When 3 was treated with 1/2 of an equivalent of [RhCl(cod)]2 (cod=1,5‐cyclooctadiene), the corresponding chlorogermylene‐Rh(I) complex 5 was obtained as orange crystals. In contrast, the reaction of 4 with a half equivalent of [RhCl(cod)]2 under a CO atmosphere resulted in the formation of a five‐membered germarhodacycle 7. Compounds 3, 4, 5, and 7 were characterized using NMR spectroscopies and single‐crystal X‐ray diffraction. Complex 5 can be employed as a catalyst for the hydrosilylation and hydroboration reactions of diphenylacetylene, thus demonstrating the utility of germylene ligands comparable to those of NHCs in the major transition metal catalytic processes.