bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-Cultural Adult ADHD Assessment in 42 Countries Using the Adult ADHD Self-Report Scale Screener
Authors: Lewczuk Karol , Marcowski Przemysław , Wizła Magdalena , Gola Mateusz , Nagy Léna , Koós Mónika , Kraus Shane W. , Demetrovics Zsolt , Potenza Marc N. , Ballester-Arnal Rafael , Batthyány Dominik , Bergeron Sophie , Billieux Joël , Briken Peer , Burkauskas Julius , Cárdenas-López Georgina , Carvalho Joana , Castro-Calvo Jesús , Chen Lijun , Ciocca Giacomo , Corazza Ornella , Csako Rita I. , Fernandez David P. , Fujiwara Hironobu , Fernandez Elaine F. , Fuss Johannes , Gabrhelík Roman , Gewirtz-Meydan Ateret , Gjoneska Biljana , Grubbs Joshua B. , Hashim Hashim T. , Islam Md. Saiful , Ismail Mustafa , Jiménez-Martínez Martha C. , Jurin Tanja , Kalina Ondrej , Klein Verena , Költő András , Lee Sang-Kyu , Lin Chung-Ying , Lin Yi-Ching , Lochner Christine , López-Alvarado Silvia , Lukavská Kateřina , Mayta-Tristán Percy , Miller Dan J. , Orosová Oľga , Orosz Gábor ,   Sungkyunkwan University’s research team, Ponce Fernando P. , Quintana Gonzalo R. , Quintero Garzola Gabriel C. , Ramos-Diaz Jano , Rigaud Kévin , Rousseau Ann , Tubino Scanavino Marco De , Schulmeyer Marion K. , Sharan Pratap , Shibata Mami , Shoib Sheikh , Sigre-Leirós Vera , Sniewski Luke , Spasovski Ognen , Steibliene Vesta , Stein Dan J. , Ünsal Berk C. , Vaillancourt-Morel Marie-Pier , Claire Van Hout Marie , Bőthe Beáta 
Published: January 2024

Objective: We analyzed adult ADHD symptoms in a cross-cultural context, including investigating the occurrence and potential correlates of adult ADHD and psychometric examination of the Adult ADHD Self-Report Scale (ASRS) Screener. Method: Our analysis is based on a large-scale research project involving 42 countries (International Sex Survey, N=72,627, 57% women, Mage=32.84; SDage=12.57). Results: The ASRS Screener demonstrated good reliability and validity, along with partial invariance across different languages, countries, and genders. The occurrence of being at risk for adult ADHD was relatively high (21.4% for women, 18.1% for men). The highest scores were obtained in the US, Canada, and other English-speaking Western countries, with significantly lower scores among East Asian and non-English-speaking European countries. Moreover, ADHD symptom severity and occurrence were especially high among gender-diverse individuals. Significant associations between adult ADHD symptoms and age, mental and sexual health, and socioeconomic status were observed. Conclusions: Present results show significant cross-cultural variability in adult ADHD occurrence as well as highlight important factors related to adult ADHD. Moreover, the importance of further research on adult ADHD in previously understudied populations (non-Western countries) and minority groups (gender-diverse individuals) is stressed. Lastly, the present analysis is consistent with previous evidence showing low specificity of adult ADHD screening instruments and contributes to the current discussion on accurate adult ADHD screening and diagnosis.
Association between demographics, socioeconomics, and disease-related factors and the perception of stigma in people with MS
Authors: Ghajarzadeh Mahsa , Fitzgerald Kathryn C , Mowry Ellen M , Nourbakhsh Bardia 
Published: January 2024

Background: Stigma is prevalent among individuals with chronic diseases, such as multiple sclerosis (MS) and those with comorbid mental health disorders, but its associated factors are poorly understood. Objective: To investigate the prevalence and correlates of stigma in people living with MS. Methods: We analyzed data from the MS Partners Advancing Technology and Health Solutions (MS PATHS) network, which collected patient information and outcomes during routine clinic visits. We used a multinomial logistic regression model to examine the cross-sectional association between stigma and demographic, socioeconomics, and MS-related factors. Results: We included 11,634 participants. The mean Neuro-QoL stigma T-score was 47.2 ± 8.6, and 17.7% of participants were classified as having moderate to severe stigma using established cutoffs. Multinomial logistic regression models suggest that higher disability levels, progressive form of the disease, shorter duration of the disease, and unemployment were associated with higher stigma while being male, married, undergoing treatment with high-efficacy disease-modifying therapies (DMTs), and being from European MS centers were associated with lower stigma perception. Disability levels, measured by Patient-Determined Disease Steps (PDDS), had the strongest independent association with stigma. Conclusion: Stigma remains a relevant issue for people living with MS. Factors, such as physical and cognitive disability, DMT, and employment status may influence the severity of perceived stigma.
The diagnosis of cerebral palsy in two Danish national registries: a validation study
Authors: Larsen Mads L. , Hoei-Hansen Christina E. , Rackauskaite Gija 
Published: January 2024

Aims: To determine the quality of prospectively collected data from the highly specialized Danish Cerebral Palsy Follow-up Program (CPOP), and to establish the validity of a reported cerebral palsy (CP) diagnosis in the Danish National Patient Registry (NPR), regularly used as a proxy for neurodevelopmental disorders in epidemiological research. Methods: We compared data from the two registries on children with registered CP, born in Denmark between 2008 and 2009, with information from medical records verified by two experienced physicians specializing in pediatric neurology. Data accuracy was estimated by completeness, correctness, and reliability. Completeness was calculated as the number of cases with correctly registered CP diagnoses divided by the total number of true CP diagnoses (similar to sensitivity). Correctness was calculated as the number of cases with correct registrations divided by the total number of cases (similar to positive predictive value). Reliability was estimated using kappa statistics. Results: Registered CP diagnoses in the CPOP had high accuracy, with 94% correctness and 91% completeness. Furthermore, most key variables in the CPOP showed excellent reliability, especially variables defining the severity of the condition. In the Danish NPR, only 225 of 348 children with a noted CP diagnosis fulfilled the diagnostic criteria for CP, resulting in 65% correctness. Conclusions: Danish CPOP data are a valid source for epidemiological research. Conversely, a noted CP diagnosis in the Danish NPR was, at best, correct in only two out of three patients.
The Medial Antebrachial Cutaneous Nerve Is a Low-Morbidity Alternative to the Standard Sural Nerve Autograft
Authors: Pripotnev Stahs , Pinni Sai L. , Zhou Suzanne , Skolnick Gary , Mackinnon Susan E. 
Published: January 2024

Background: Nerve interposition grafting is an important technique in nerve reconstructive surgery that is used when a primary repair is not feasible without significant tension. This study sought to evaluate the long-term morbidity of the medial antebrachial cutaneous (MABC) nerve as an alternative donor nerve in comparison with sural nerve harvest. Methods: A single surgeon and institution retrospective chart review was performed to identify all patients who underwent nerve autografting using the sural and MABC as donor nerves between January 1, 2000 and December 31, 2019. Surveys assessed overall patient satisfaction with surgery, as well as donor and recipient site morbidity, satisfaction, pain, numbness, and cold sensitivity. Results: Of the 73 patients contacted, 54 agreed to participate, and 43 of 73 (58.9%) ultimately completed the survey: 28 MABC (65.1%) and 15 sural (34.9%). There were no significant differences between the sural and MABC groups in overall satisfaction with surgery, donor and recipient site satisfaction, pain, cold sensitivity, and effect on quality of life. Even though 66.7% of sural donor sites and 75% of MABC donor sites had residual numbness, the effect this had on quality of life was very low (2 and 3, respectively). Conclusion: The MABC is a safe alternative to the traditional sural nerve autograft. A small subset of patients undergoing nerve autograft harvest will experience long-term morbidity in the form of pain. Conversely, the more common presence of numbness is not reported as bothersome.
Non-vascularized metatarsal transfer for thumb hypoplasia: a medium- to long-term retrospective study of 41 patients
Authors: Iigaya Ruriko , Takagi Takehiko , Seki Atsuhito , Takayama Shinichiro 
Published: January 2024

We retrospectively reviewed 41 Manske type IIIB and IV hypoplastic thumbs reconstructed with non-vascularized fourth metatarsal transfers with a mean age of 3.1 years (range 2–7) at the time of operation. These patients were observed for at least 5 years postoperatively. Of the 41 hands, 13 developed complications: type IV patients had significantly more complications ( p = 0.014) although using an additional cerclage wire for bony fixation significantly reduced the complication rate ( p = 0.045). Of the 31 hands examined with regard to growth, eight exhibited early physeal arrest of bone graft within 5 years postoperatively. The growth rate of the reconstructed first metacarpal bone was significantly lower than that of the second metacarpal bone 10 years after surgery ( p = 0.041). Transfer of the non-vascularized fourth metatarsal remains an alternative for type IIIB and IV hypoplastic thumbs if parents desire to keep a five-fingered hand. Level of evidence: III
As simple as it sounds? The treatment of simple bone cysts in the proximal femur in children and adolescents: Retrospective multicenter EPOS study of 74 patients
Authors: van Geloven Thomas PG , van der Heijden Lizz , Laitinen Minna K , Campanacci Domenico A , Döring Kevin , Dammerer Dietmar , Badr Ismail T , Haara Mikko , Beltrami Giovanni , Hobusch Gerhard M , Kraus Tanja , Scheider Philipp , Soto-Montoya Camilo , Umer Masood , Saeed Javeria , Funovics Phillipp T , Fiocco Marta , van de Sande Michiel AJ , de Witte Pieter Bas 
Published: January 2024

Purpose: Simple bone cysts are among the most prevalent benign cystic tumor-like lesions in children. Proximal femoral simple bone cysts may require specific treatment because of increased fracture risk. With limited literature available on this specific localization, consensus regarding optimal treatment is lacking. We present a large international multicenter retrospective cohort study on proximal femoral simple bone cysts. Methods: All consecutive pediatric patients with proximal femoral simple bone cyst from 10 tertiary referral centers for musculoskeletal oncology were included (2000–2021). Demographics, primary treatment, complications, and re-operations were evaluated. Primary outcomes were time until full weight-bearing and failure-free survival. Results: Overall, 74 simple bone cyst patients were included (median age 9 years (range = 2–16), 56 (76%) male). Median follow-up was 2.9 years (range = 0.5–21). Index procedure was watchful waiting (n = 6), percutaneous procedure (n = 12), open procedure (n = 50), or osteosynthesis alone (n = 6). Median time until full weight-bearing was 8 weeks (95% confidence interval = 0.1–15.9) for watchful waiting, 9.5 (95% confidence interval = 3.7–15.3) for percutaneous procedure, 11 (95% confidence interval = −0.7 to 13.7) for open procedure, and 6.5 (95% confidence interval = 5.9–16.1) for osteosynthesis alone (p = 0.58). Failure rates were 33%, 58%, 29%, and 0%, respectively (p = 0.069). Overall failure-free survival at 1, 2, and 5 years was 77.8% (95% confidence interval = 68.2–87.4), 69.5% (95% confidence interval = 58.5–80.5), and 62.0% (95% confidence interval = 47.9–76.1), respectively. Conclusion: A preferred treatment for proximal femoral simple bone cysts remains unclear, with comparable failure rates and times until full weight-bearing. Watchful waiting may be successful in certain cases. If not feasible, osteosynthesis alone can be considered. Treatment goals should be cyst control, minimizing complications and swift return to normal activities. Therefore, an individualized balance should be made between undertreatment, with potentially higher complication risks versus overtreatment, resulting in possible larger interventions and accompanying complications. Level of evidence: Level IV, retrospective multicentre study
Changes in care managers’ positive attitudes toward dying patients compared to that of nurses by one-day online advance care planning communication training
Authors: Oshiro Kyoko , Okochi Shozo , Nakashima Junko , Hirano Tomoko , Ohe Shuichi , Kojima Hideki , Nishikawa Mitsunori 
Published: January 2024

Background: Culturally appropriate communication training programs for a wide range of professions that can be used during infection epidemics are crucial for advance care planning implementation. Starting in 2018, the Japanese Ministry of Health, Labour and Welfare made a major policy change, and doctors, nurses, and social workers, and care managers were identified in the guidelines as the professions that promote advance care planning. Motivated by the lack of online programs for Japanese care managers, we proposed a new one-day program. Objectives: This study aimed to determine the changes in the positive attitude of care managers toward dying patients compared to that of nurses, which has been used in past literature as an outcome of advance care planning educational interventions, after administering the program in Japan. Design: Before-after comparison study. Methods: Care managers were recruited through our website, ACP-Piece, http://plaza.umin.ac.jp/~acp-piece/piece.html . A questionnaire survey concerning positive attitudes toward dying patients was administered before and after the program on 28 August 2021. Sixty-six subjects participated in the training and 60 participants, including 14 care managers, consented to the study and completed the questionnaire surveys before and after the program. Results: The Frommelt attitude toward care of the dying scores for care managers increased after the program ( p-values, confidence intervals, and effect sizes: p < 0.001, −11.90 to −4.388, −1.252). After training, care managers had a significantly higher maximum score occurrence than nurses. Older care managers with advance care planning experience may have had a higher maximum score occurrence compared to younger, inexperienced participants. Conclusion: To our knowledge, this is the first to demonstrate the increased positive attitude scores toward dying patients after online communication training for Japanese care managers. The limitations of this study include the lack of evidence regarding reasons for score changes, long-term score changes, and effectiveness for patients and their families.
Fixation in Maxillofacial Surgery—Past, Present and Future: A Narrative Review Article
Authors: Ahmad Wasim , Ganguly Akash , Hashmi Ghulam Sarwar , Ansari Md Kalim , Rahman Tabishur , Arman Mohammad 
Published: January 2024

Introduction:The present review explores the existing documentation in the literature related to the fixation of mandibular fractures undertaken in maxillofacial surgery.Methods:English language articles were searched in various databases such as Pubmed, Scopus, Science Direct and Google Scholar. The keyword used for searching are “Mandible Fracture,” “Maxillomandibular fixation,” “Fixation” and “Recent Advancements.”Results about the history of fixation:Extended history into the pre-Christian era, early medieval, through the 17th, 18th and 19th, 20th, 21st centuries have been dealt in the narrative review. Emphasis on the present plating system with focus on present and future prospects like AI, virtual reality as well as Magnesium based plating systems have also been dealt here.Conclusions:The present review spotlights on understanding present, past, and future aspects of fixation of mandibular fractures. Currently, titanium plates are being used and the most popular materials though future holds good prospects for polymer based and magnesium based materials.
IELSG30 phase 2 trial: intravenous and intrathecal CNS prophylaxis in primary testicular diffuse large B-cell lymphoma
Authors: Conconi Annarita , Chiappella Annalisa , Ferreri Andrés J. M. , Stathis Anastasios , Botto Barbara , Sassone Marianna , Gaidano Gianluca , Balzarotti Monica , Merli Francesco , Tucci Alessandra , Vanazzi Anna , Tani Monica , Bruna Riccardo , Orsucci Lorella , Cabras Maria Giuseppina , Celli Melania , Annibali Ombretta , Liberati Anna Marina , Zanni Manuela , Ghiggi Chiara , Pisani Francesco , Pinotti Graziella , Dore Fausto , Esposito Fabiana , Pirosa Maria Cristina , Cesaretti Marina , Bonomini Luisella , Vitolo Umberto , Zucca Emanuele 
Published: January 2024

Abstract
Primary testicular diffuse large B-cell lymphoma (PTL) is characterized by high risk of contralateral testis and central nervous system (CNS) relapse. Chemoimmunotherapy with intrathecal (IT) CNS prophylaxis and contralateral testis irradiation eliminates contralateral recurrences and reduces CNS relapses. The IELSG30 phase 2 study investigated feasibility and activity of an intensified IT and IV CNS prophylaxis. Patients with stage I/II PTL who had not received treatment received 2 cycles of IV high-dose methotrexate (MTX) (1.5 g/m2) after 6 cycles of the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone, every 21 days). IT liposomal cytarabine was administered on day 0 of cycles 2 to 5 of 21-day R-CHOP regimen. Contralateral testis radiotherapy (25-30 Gy) was recommended. Fifty-four patients (median age: 66 years) with stage I (n = 32) or II (n = 22) disease were treated with R-CHOP, 53 received at least 3 doses of IT cytarabine, 48 received at least 1 dose of IV MTX, and 50 received prophylactic radiotherapy. No unexpected toxicity occurred. At a median follow-up of 6 years, there was no CNS relapse; 7 patients progressed, and 8 died, with 5-year progression-free and overall survival rates of 91% (95% confidence interval [CI], 79-96) and 92% (95% CI, 81-97), respectively. Extranodal recurrence was documented in 6 patients (in 2 without nodal involvement). In 4 cases, the relapse occurred &gt;6 years after treatment. Causes of death were lymphoma (n = 4), second primary malignancy (n = 1), cerebral vasculopathy (n = 1), unknown (n = 2). Intensive prophylaxis was feasible and effective in preventing CNS relapses. Late relapses, mainly at extranodal sites, represented the most relevant pattern of failure. This trial was registered at www.clinicaltrials.gov as #NCT00945724.
Dynamics and concordance alterations of regional brain function indices in vestibular migraine: a resting-state fMRI study
Authors: Xiong Xing , Dai Lingling , Chen Wen , Lu Jiajie , Hu Chunhong , Zhao Hongru , Ke Jun 
Published: January 2024

Abstract
Background
Prior MRI studies on vestibular migraine (VM) have revealed abnormalities in static regional intrinsic brain activity (iBA) and dynamic functional connectivity between brain regions or networks. However, the temporal variation and concordance of regional iBA measures remain to be explored.

Methods
57 VM patients during the interictal period were compared to 88 healthy controls (HC) in this resting-state functional magnetic resonance imaging (fMRI) study. The dynamics and concordance of regional iBA indices, including amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo), were examined by utilizing sliding time-window analysis. Partial correlation analyses were performed between clinical parameters and resting-state fMRI indices in brain areas showing significant group differences.

Results
The VM group showed increased ALFF and ReHo dynamics, as well as increased temporal concordance between ALFF and ReHo in the bilateral paracentral lobule and supplementary motor area relative to the HC group. We also found decreased ReHo dynamics in the right temporal pole, and decreased ALFF dynamics in the right cerebellum posterior lobe, bilateral angular gyrus and middle occipital gyrus (MOG) in the VM group compared with the HC group. Moreover, a positive correlation was observed between ALFF dynamics in the left MOG and vertigo disease duration across all VM patients.

Conclusion
Temporal dynamics and concordance of regional iBA indices were altered in the motor cortex, cerebellum, occipital and temporoparietal cortex, which may contribute to disrupted multisensory processing and vestibular control in patients with VM. ALFF dynamics in the left MOG may be useful biomarker for evaluating vertigo burden in this disorder.
Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-κB pathway in a chronic migraine model
Authors: Sun Songtang , Fan Zhenzhen , Liu Xuejiao , Wang Longde , Ge Zhaoming 
Published: January 2024

Abstract
Background
Neuroinflammation, mediated by the activation of microglia, contributes to central sensitization, which is associated with the development of chronic migraine (CM). TREM1 receptors amplify the inflammatory response. However, their relationship to CM is unclear. Thus, this study endeavoured to elucidate the exact role of TREM1 in CM.

Methods
Nitroglycerin (NTG) was repeatedly administered intraperitoneally to establish the CM model. Mechanical and thermal sensitivities were assessed using von Frey filaments and hot plate assays. Using Western blotting, TREM1, NF-κB pathway, NLRP3 inflammasome components, and proinflammatory cytokines were all detected. Immunofluorescence was used to examine the cellular distribution of TREM1 and NLRP3, the number of microglia, immunoreactivity, and morphological changes. We examined the effects of TREM1 antagonists (LR12) and NF-κB inhibitors (PDTC) on pain behaviour, as well as the production of c-fos and CGRP. Additionally, we investigated whether LR12 and PDTC affect the activation of microglia and the NLRP3 inflammasome. We synthesized siRNA and TREM1-overexpressing plasmids to transfect BV2 cells treated with LPS and normal BV2 cells and treated TREM1-overexpressing BV2 cells with PDTC. The NF-κB pathway, NLRP3 inflammasome components, and proinflammatory cytokines were quantified using Western blotting.

Results
Following NTG administration, the expression of TREM1 was significantly upregulated and exclusively localized in microglia in the TNC, and was well co-localized with NLRP3. Furthermore, activation of the classical NF-κB pathway was observed. Pre-treatment with LR12 and PDTC effectively attenuated mechanical hypersensitivity, suppressed the expression of c-fos and CGRP, and inhibited NF-κB activity in CM mice. Additionally, inhibition of TREM1 and NF-κB activity mitigated NTG-induced microglia and NLRP3 activation, as well as proinflammatory cytokines production. In vitro, knockdown of TREM1 resulted in attenuated activation of the NF-κB pathway following lipopolysaccharide (LPS) treatment and reduced expression of NLRP3 inflammasome components as well as proinflammatory cytokines. After TREM1 overexpression, the NF-κB pathway was activated, NLRP3 inflammasome components and proinflammatory cytokines were upregulated, and PDTC reversed this phenomenon.

Conclusions
Our findings suggest that TREM1 regulates microglia and NLRP3 activation via the NF-κB pathway, thereby contributing to central sensitization and implicating its involvement in chronic migraine pathogenesis.