bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of autologous plasminogen on the rate of healing of chronic skin ulcers in patients with diabetes mellitus and the level of proteins - markers of hypoxia and angiogenesis
Authors: Badziukh Sergiy , Petrenko Oleg , Bezrodnyi Boris , Tykhomyrov Artem 
Published: October 2023

chronic diabetic wounds are a complication of diabetes mellitus that develop as a result of the toxic effects of hyperglycemia, which leads to metabolic disorders with the development of immunosuppression, angiopathy, and neuropathy. A considerable amount of experimental data has been accumulated, which indicates that the participation of the plasminogen-plasmin system in wound healing is not only to clear wounds of fibrin clots, but also to fine-tune the activity of cells that ensure an adequate course of all stages of healing. This study was conducted to investigate the effect of autologous plasminogen on the rate of chronic wound healing in patients with diabetic foot syndrome. The study involved 45 patients with purulent necrotic form of diabetic foot. The efficacy of topical application of standard medications was compared with the application of autologous plasminogen. The wound area was measured once every two days until complete healing. To study the molecular mechanisms of plasminogen effect on wound healing, the level of marker proteins of key physiological processes associated with healing, namely hypoxia and angiogenesis, was determined. The levels of protein regulators of angiogenesis (vascular endothelial cell growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α) and angiostatins) in the skin tissue of wounds at the beginning and end of treatment with autologous plasminogen in patients with chronic diabetic wounds with neuropathic diabetic foot were evaluated. The levels of VEGF, HIF-1α and angiostatins were determined by Western blotting. We have found that wound tissue in patients with chronic diabetic wounds before treatment is characterized by a reduced level of VEGF, which represents the inability of these wounds to regenerate. At the same time, an increased level of HIF-1α and angiostatins is detected. After treatment with autologous plasminogen applications, a significant increase in VEGF expression was observed against the background of a progressive decrease in HIF-1α and angiostatin activity. The results indicate that increased production of angiogenic inhibitors may counteract angiogenesis and contribute to the failure of chronic wound healing. The use of plasminogen applications reduces the level of angiostatins in wound biopsies, which allowed to increase the level of proangiogenic factors. Treatment with plasminogen demonstrated an improvement in the condition of the wound surface and the transition of healing to the proliferative phase due to the initiation of the inflammatory process in wounds. The results of planimetric measurement of the wound area indicate a 5-fold reduction in the time required for complete wound healing in the group receiving plasminogen applications compared to this parameter in the comparison group.
Minimalistic System of Characteristics of Non-linear Baseband Pulse Devices and Its Measurement
Authors: Nazarov M. A. , Semyonov E. V. 
Published: October 2023

Introduction. The general system of parameters, including compression points and intersection points of various harmonics, is unsuitable for devices operating under the influence of baseband pulses (for example, before the modulator in the transmitter, after the demodulator in the receiver). Previously, the authors have developed simple models in the form of nonlinear recursive filters, which give a satisfactory error in describing the response of a wide class of baseband pulse circuits. The system of nonlinear functions of such models can be considered as a new system of characteristics of nonlinear-dynamical baseband impulse circuits, for which it is necessary to develop a method that ensures their measurement with an acceptable error. In the general formulation, this problem is rather challenging; therefore, this article considers only a first-order nonlinear recursive filter. However, the obtained result gives satisfactory results for devices without flat top transient overshoot.Aim. To consider a method for measuring the characteristics of nonlinear-dynamical baseband impulse devices without overshoot on the flat top of the transient response.Materials and methods. The considered recursive filter is represented by an equivalent circuit consist of nonlinear resistive and capacitive elements. Therefore, the task is reduced to measuring their current-voltage characteristics (IV) and charge-voltage characteristics (CVC). IV characteristics are measured at the flat tops of the transient characteristics of the device. Having a certain IV, we obtain the opportunity to calculate the current (and then the charge) of the capacitive element. The experimental study was carried out on the example of a three-stage amplifier with an aperiodic transient response.Results. The transient characteristics of the filter are approximated by the model with an accuracy of no worse than 3.2 %.Conclusion. The considered system of functions can be obtained with a definable error that satisfactory for practice, which allows it to be considered as a new system of parameters for nonlinear baseband pulse devices.
Noise Generators (A Review)
Authors: Vinokurov S. A. , Kochemasov V. N. , Safin A. R. 
Published: October 2023

Introduction. At present, noise generators (noise signal generators) have a wide range of applications. For example, such devices can be used as sources of fluctuating interference when studying the limiting sensitivity of radio receivers and amplifying devices, as signal simulators of multi-channel communication equipment, as tools for measuring non-linear distortions and frequency characteristics of radio devices using spectrum analyzers with a constant bandwidth.Aim. Review of scientific achievements in the development of noise generators and their applications.Materials and methods. The material for analysis was collected using databases of scientific publications, online resources, and websites of noise generator manufacturers. The research spanned the timeframe of 60 years.Results. Various noise generators and their characteristics, currently available on the radio equipment market, are described. The analysis of their main technical characteristics is carried out; examples of their practical application are indicated.Conclusion. Noise signal generators are widely used in scientific research and are currently produced mainly by foreign companies. Domestic companies are poorly represented in this market, with little published information available. However, positive developments in this direction have recently been observed. Domestic manufacturers are launching R&D programs to develop noise signal generators, which could reduce dependence on imported products in the future
A Substrate Integrated Waveguide Slotted Antenna
Authors: Koshkid’ko V. G. , Galtsov Ya. O. , Portnykh D. A. 
Published: October 2023

Introduction. Slotted waveguide antenna arrays are widely used across centimeter- and millimeter-wavelength ranges due to numerous advantages, including their good directional properties, compact dimensions, flat shape, convenience of power supply, and high efficiency. At the same time, the current trend toward miniaturization of electronic devices and their integration requires new solutions, such as the development of devices based on wave-guides integrated into the substrate (Substrate Integrated Waveguide – SIW).Aim. To simulate a SIW-based slotted antenna with characteristics similar to those of a conventional antenna array based on a hollow metal waveguide.Materials and methods. The Ansys HFSS software was used to simulate the structure under study and to carry out electro-magnetic modeling and analysis of its directional properties. The energy method was used to determine the coordinates of longitudinal slots on the wide wall of the SIW waveguide. Macros were developed in the Visual Basic Scripting Edition language to automate routine operations for creating and deleting objects of the same type when constructing a model. The Arlon AD300C microwave material was used to manufacture a printed version of the SIW waveguide.Results. The process of developing a SIW slotted antenna was carried out in the following stages: construction of a reference model based on a hollow metal waveguide followed by creating a transition model based on a waveguide completely filled with a dielectric and the final SIW-based model. At each stage, the radiation pattern was monitored to obtain the directional properties of the SIW slotted antenna with characteristics identical to those of an antenna based on the reference hollow metal waveguide.Conclusion. A SIW slotted antenna with the required characteristics was simulated and tested in the Ansys HFSS environment. Such an antenna employs one of the main advantages of the SIW technology, i.e., the possibility of integrating all components on a single substrate, including antenna arrays, passive components, and active elements. This approach provides the basis for reducing the size of microwave devices and their miniaturization.
Evaluation of Dimensional Characteristics of Conductive Pattern Elements of 3D-Printed Circuit Boards
Authors: Smirnova O. N. , Aleksandrov A. A. , Bobrova Yu. S. , Moiseev K. M. 
Published: October 2023

Introduction. A review of foreign publications on 3D printing methods shows the possibility of their application for the manufacture of printed circuit boards (PCBs), while demonstrating the growth of interest in this field. One of the available methods is fused deposition modeling, which can be used to form substrates with channels for traces. At present, the minimum channel width comprises 100 µm, which corresponds to the 5th class of PCB accuracy. However, there is no data on how to obtain such dimensions or on the magnitude of their deviation from the given nominal values.Aim. To determine the influence of such factors as nozzle diameter and the number of contours on the dimensional characteristics of PCBs (linear dimensions; trace channel width; trace spacing; via diameters).Materials and methods. To obtain linear models, a full factorial experiment was carried out. The influence of the following materials was evaluated – polylactide (PLA), acrylonitrile butadiene styrene (ABS) and glass-filled ABS; slicers – Ultimaker Cura and PrusaSlicer; 3D printers – Picaso 3D Designer Classic 2016 and Hercules Strong 2017; brass nozzle with diameters ∅0.2 and ∅0.4 mm. The possibility of using brass nozzles coated with chemical nickel for printing with glass-filled filaments was considered. The study was conducted using the facilities of the "Center for Additive Technologies" of Bauman Moscow State Technical University.Results. The possibility of manufacturing PCBs up to the 2nd and 3rd accuracy classes using nozzles with a diameter of ∅0.4 and ∅0.2 mm, respectively, was shown. It was found that galvanic deposition of chemical nickel on a ∅0.2 mm brass nozzle makes it possible to increase the PCB wearability when printing with glass-filled filaments. Recommendations are proposed for selecting an optimal combination of nozzle diameter and the number of contours.Conclusion. The conducted analysis of mathematical models shows the significance of such parameters as nozzle diameter and the number of contours. The results can be used when creating new PCB layouts
Simulation of Spatial Polarization Characteristics of a Triorthogonal Antenna Element for the Tasks of HF Band Bearing
Authors: Gribov G. S. 
Published: October 2023

Introduction. Achieving improved accuracy and sensitivity of the direction finding of radio signals represents a relevant research direction in the field of modern HF radio monitoring. HF radio waves propagate through ionospheric layers, which distorts the polarization parameters of the passing electromagnetic wave (EMW). One possible approach to improve the accuracy and sensitivity of the direction finding of HF radio signals consists in the use of an antenna element capable of accepting both components of the electromagnetic field in the antenna array.Aim. A comparative analysis of the proposed triorthogonal antenna element with existing solutions for the tasks of HF band bearing.Materials and methods. Antenna elements and their spatial polarization characteristics were simulated in the MATLAB environment using the Phased Array toolbox.Results. The spatial polarization characteristics of the triorthogonal antenna under study were constructed and compared with an asymmetric vertical vibrator and a biorthogonal antenna. The comparison showed that at small elevation angles, the triorthogonal antenna ensures an energy gain of up to 4.5 dB compared to a biorthogonal antenna and an asymmetric vertical vibrator. At elevation angles of 30…60° and over 60°, the increase in the quality of a signal received by the triorthogonal antenna element reaches 3 dB and 2 dB, respectively.Conclusion. According to the obtained spatial polarization characteristics, the triorthogonal antenna under study can be part of a large-base antenna array of the HF band. The use of this antenna will increase the accuracy and sensitivity of direction finding by means of matching the antenna element with the EMW polarization
Management of recurrent chronic suppurative otitis media with cholesteatoma
Authors: Christianty Finna , Wahyudiono Ahmad Dian 
Published: October 2023

Background: Chronic suppurative otitis media (CSOM) is a chronic inflammation involving the middle ear space and it became a burden especially in developing countries. Mastoidectomy remains the main treatment in CSOM with cholesteatoma. Recurrent cholesteatoma and suppurating process indicated the need of revision mastoidectomy. Purpose: Until now, study about the mechanism of recurrent cholesteatoma and its management still need further research. Case report: This paper reports a case of chronic suppurative otitis media with recurrent cholesteatoma which underwent revision mastoidectomy. Clinical Question : What are the factors associated with the occurrence of recurrent cholesteatoma and how to managed it? Methods: Evidence base literature study about chronic suppurative otitis media with recurrent cholesteatoma and surgery treatment was performed through PubMed, ProQuest, and Google Scholar database. Results: Recurrent cholesteatoma that occurred after mastoidectomy can be caused by residue of the cholesteatoma itself or new forming of retraction pocket. Revision mastoidectomy is necessary to evacuated the cholesteatoma and provide good drainage to the mastoid. Conclusion: Routine follow up after mastoidectomy is an important thing to help prevent recurrence of CSOM especially with cholesteatoma.
Creating a Forum for Library Professionals: A Case Study of CALA Canada Chapter
Authors: Jin Lei , Liu Guoying , Zhang Wei 
Published: October 2023

<p>This paper examines the establishment, growth, achievements, and future planning of the CALA Canada Chapter. Since its inception in June 2018, the Chapter has experienced significant growth, with the number of members doubling, and the number of life members also doubling. Currently there are a total of thirty members in the Chapter, comprising ten life members, eight overseas members, and seven student members, with the majority residing or working in Ontario. The Chapter has achieved notable milestones, including the organization of successful events such as conferences, workshops, and networking sessions. The Chapter has also contributed to the development of the library profession in Canada, particularly by promoting diversity and inclusivity. Looking forward, the Chapter plans to expand its reach and increase its membership by promoting itself in other regions of the country. The Chapter aims to continue providing valuable resources, programs, and opportunities for its members to enhance their professional development and foster collaboration. Through these efforts, the Canada Chapter aims to play an essential role in advancing the library profession in Canada and promoting its growth and innovation.</p>
<p><a href="https://journal.calaijol.org/index.php/ijol/article/view/300/377" target="_blank">PDF</a><br>
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Dynamic segmental kinematics of the lumbar spine during diagnostic movements
Authors: McMullin Paul , Emmett Darian , Gibbons Andrew , Clingo Kelly , Higbee Preston , Sykes Andrew , Fullwood David T. , Mitchell Ulrike H. , Bowden Anton E. 
Published: October 2023

Background:In vivo measurements of segmental-level kinematics are a promising avenue for better understanding the relationship between pain and its underlying, multi-factorial basis. To date, the bulk of the reported segmental-level motion has been restricted to single plane motions.Methods: The present work implemented a novel marker set used with an optical motion capture system to non-invasively measure dynamic, 3D in vivo segmental kinematics of the lower spine in a laboratory setting. Lumbar spinal kinematics were measured for 28 subjects during 17 diagnostic movements.Results: Overall regional range of motion data and lumbar angular velocity measurement were consistent with previously published studies. Key findings from the work included measurement of differences in ascending versus descending segmental velocities during functional movements and observations of motion coupling paradigms in the lumbar spinal segments.Conclusion: The work contributes to the task of establishing a baseline of segmental lumbar movement patterns in an asymptomatic cohort, which serves as a necessary pre-requisite for identifying pathological and symptomatic deviations from the baseline.
Differences in running biomechanics between young, healthy men and women carrying external loads
Authors: Rubio Jose E. , Tong Junfei , Sundaramurthy Aravind , Subramani Adhitya V. , Kote Vivek Bhaskar , Baggaley Michael , Edwards W. Brent , Reifman Jaques 
Published: October 2023

During U.S. Army basic combat training (BCT), women are more prone to lower-extremity musculoskeletal injuries, including stress fracture (SF) of the tibia, with injury rates two to four times higher than those in men. There is evidence to suggest that the different injury rates are, in part, due to sex-specific differences in running biomechanics, including lower-extremity joint kinematics and kinetics, which are not fully understood, particularly when running with external load. To address this knowledge gap, we collected computed tomography images and motion-capture data from 41 young, healthy adults (20 women and 21 men) running on an instrumented treadmill at 3.0 m/s with loads of 0.0 kg, 11.3 kg, or 22.7 kg. Using individualized computational models, we quantified the running biomechanics and estimated tibial SF risk over 10 weeks of BCT, for each load condition. Across all load conditions, compared to men, women had a significantly smaller flexion angle at the trunk (16.9%–24.6%) but larger flexion angles at the ankle (14.0%–14.7%). Under load-carriage conditions, women had a larger flexion angle at the hip (17.7%–23.5%). In addition, women had a significantly smaller hip extension moment (11.8%–20.0%) and ankle plantarflexion moment (10.2%–14.3%), but larger joint reaction forces (JRFs) at the hip (16.1%–22.0%), knee (9.1%–14.2%), and ankle (8.2%–12.9%). Consequently, we found that women had a greater increase in tibial strain and SF risk than men as load increases, indicating higher susceptibility to injuries. When load carriage increased from 0.0 kg to 22.7 kg, SF risk increased by about 250% in women but only 133% in men. These results provide quantitative evidence to support the Army’s new training and testing doctrine, as it shifts to a more personalized approach that shall account for sex and individual differences.
Correlations between the expression of molecules in the TGF-β signaling pathway and clinical factors in adamantinomatous craniopharyngiomas
Authors: Jin Lu , Cai Kefan , Wu WenTao , Xiao Youchao , Qiao Ning , Liu Fangzheng , Ru Siming , Cao Lei , Zhu Haibo , Bai Jiwei , Liu Chunhui , Li Chuzhong , Zhao Peng , Zhang Yazhuo , Gui Songbai 
Published: October 2023

ObjectiveTo investigate the clinical and pathological factors associated with preoperative hypothalamus invasion and postoperative outcomes of adamantinomatous craniopharyngiomas (ACPs) after the expanded endonasal approach (EEA) resection.MethodsNinety-three specimens of ACPs, consisting of 71 primary and 22 recurrent tumors, were investigated for the expression of TGF-β1, SMAD2, SMAD3, and β-catenin by immunohistochemistry staining. The clinical information of relevant patients, including the extent of resection, hypothalamus invasion, endocrinopathy, complications, and prognosis, was reviewed. The relationships between the expression of these immunopathological markers and clinical factors were analyzed.ResultsEndocrinological dysfunctions were more common in recurrent patients and primary patients with hypothalamus invasion in the comparisons. For recurrent patients, the rate of gross total resection (GTR) was significantly lower than for primary patients (63.6% vs. 90.1%, P = 0.007). According to radiological and intraoperative findings, invasive ACPs (IACPs) included 48 (67.6%) cases in primary tumors. The expression of TGF-β1 and β-catenin was significantly higher in recurrent tumors (P = 0.021 and P = 0.018, respectively) and IACPs (P = 0.008 and P = 0.004, respectively). The expression level of TGF-β1 was associated with hypothalamus involvement (Puget grade, P = 0.05; Vile grade, P = 0.002), postoperative endocrinopathy (P = 0.01), and pituitary stalk preservation (P = 0.008) in primary patients. In addition, the extent of resection, treatment history, hypothalamic invasion, and level of TGF-β1 expression had significant influences on tumor recurrence/progression after surgery separately.ConclusionOur study demonstrated the potential role of TGF-β1 in the regulation of hypothalamus invasion in ACPs and the prediction of prognosis after EEA surgery. The TGF-β signaling pathway may represent a crucial mechanism in the aggressive behavior and progression of ACPs.
In vivo retinal imaging is associated with cognitive decline, blood-brain barrier disruption and neuroinflammation in type 2 diabetic mice
Authors: Majimbi May , McLenachan Samuel , Nesbit Michael , Chen Fred K. , Lam Virginie , Mamo John , Takechi Ryu 
Published: October 2023

IntroductionType 2 diabetes (T2D) is associated with chronic inflammation and neurovascular changes that lead to functional impairment and atrophy in neural-derived tissue. A reduction in retinal thickness is an early indicator of diabetic retinopathy (DR), with progressive loss of neuroglia corresponding to DR severity. The brain undergoes similar pathophysiological events as the retina, which contribute to T2D-related cognitive decline.MethodsThis study explored the relationship between retinal thinning and cognitive decline in the LepRdb/dbmodel of T2D. Diabetic db/db and non-diabetic db/+ mice aged 14 and 28 weeks underwent cognitive testing in short and long-term memory domains andin vivoretinal imaging using optical coherence tomography (OCT), followed by plasma metabolic measures andex vivoquantification of neuroinflammation, oxidative stress and microvascular leakage.ResultsAt 28 weeks, mice exhibited retinal thinning in the ganglion cell complex and inner nuclear layer, concomitant with diabetic insulin resistance, memory deficits, increased expression of inflammation markers and cerebrovascular leakage. Interestingly, alterations in retinal thickness at both experimental timepoints were correlated with cognitive decline and elevated immune response in the brain and retina.DiscussionThese results suggest that changes in retinal thickness quantified within vivoOCT imaging may be an indicator of diabetic cognitive dysfunction and neuroinflammation.