bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operative Positioning and Intraoperative-Acquired Pressure Injury: A Retrospective Cohort Study
Authors: Xu Xin , Miao Miao , Shi Guirong , Zhang Peipei , Liu Ping , Zhao Bing , Jiang Liping 
Published: February 2024

ABSTRACT

OBJECTIVE
To comprehensively assess the association between operative positioning with intraoperative-acquired pressure injury (IAPI) development.

METHODS
This retrospective cohort study included 455 patients who underwent surgery between October 2020 and January 2021. The authors grouped patients by operative positioning into the prone position and nonprone position groups. They used propensity-score matching at a 1:2 ratio to control for preoperative confounders, applied multiple logistic regression models to analyze the effects between positioning and IAPI, and assessed interactions of positioning and intraoperative factors on IAPI.

RESULTS
The final enrollment was 92 cases in the prone position group and 181 in the nonprone position group. Multivariable logistic analysis suggested that the prone position had a 2.92 times higher risk of IAPI than the nonprone position (odds ratio, 2.92; 95% CI, 1.13–7.57; P = .026). Subgroup analysis showed a significant multiplicative interaction between positioning and foam dressing on IAPI (P < .05), which was not observed in other intraoperative factors (P > .05).

CONCLUSIONS
This study provides evidence that prone operative positioning can increase IAPI risk. Patients in the prone position may particularly benefit from using dressings in Chinese populations. Further large-sample longitudinal studies are required to confirm these findings.
The Impact of COVID-19 on Rates of Pressure Injuries Among Hospitalized Patients across the US
Authors: Gomez-Rexrode Amalia E. , Lane Megan , Ashbaugh Kathryn , Kamdar Neil , Sears Erika D. 
Published: February 2024

ABSTRACT

OBJECTIVE
To determine the impact of the COVID-19 pandemic on hospital-acquired pressure injury (HAPI) rates and composition of HAPI stages among hospitalized patients across the US.

METHODS
Using encounter-level data from a nationwide healthcare insurance claims database, the authors conducted a retrospective cohort study and an interrupted time-series analysis to determine HAPI rates among hospitalized patients within 90 days of admission before (January 2018 to February 2020) and after (March 2020 to December 2020) the onset of the COVID-19 pandemic. Of 3,418,438 adult patients assessed for inclusion in the study, 1,750,494 met the inclusion criteria. Outcomes measured included the presence of a HAPI within 90 days of admission and HAPI stage based on the International Classification of Diseases, 10th Revision diagnosis codes.

RESULTS
The authors identified HAPIs in 59,175 episodes of care, representing 59,019 unique patients and corresponding to an overall HAPI rate of 2.65%. Baseline characteristics did not vary significantly across the two time periods. Further, HAPI rates were consistent across the time periods analyzed with no significant differences in rates following the onset of the pandemic (P = .303). Composition of HAPI stages remained consistent across the pandemic (unspecified, stages 1–4, Ps = .62, .80, .22, .23, and .52, respectively) except for a significant decrease in unstageable/deep tissue pressure injuries (−0.088%, P = .0134).

CONCLUSIONS
Although hospital resources were strained at the peak of the COVID-19 pandemic, no differences were identified in HAPI rates among the study’s cohort of privately insured patients.
Lumbar Vertebral Body Tethering
Authors: Stein Alan A. , Samdani Amer F. , Schupper Alexander J. , Naseer Zan , Shah Ronit V. , Zeller Sabrina , Pahys Joshua M. , Samuel Solomon Praveen , Quinonez Alejandro , Hwang Steven W. 
Published: February 2024

Study Design.
Retrospective cohort study.

Objective.
To evaluate the outcomes and reoperation rates in patients with adolescent idiopathic scoliosis undergoing lumbar anterior vertebral body tethering (AVBT).

Background.
AVBT is a viable option for growing children. The benefit of motion preservation must be balanced by a higher reoperation rate. A paucity of reports has addressed lumbar AVBT.

Materials and Methods.
A single-center retrospective study was conducted to identify all patients who underwent lumbar AVBT (lowest instrumented vertebra L3 or L4) with a minimum of 2 years of follow-up. Clinical and radiographic parameters, including complications and reoperations, were also collected. Statistical analysis was performed using the Student t test for qualitative variables.

Results.
From a data set of 551 patients, we identified 106 patients (89% female) who underwent a lumbar AVBT (33 lumbar only, 73 bilateral thoracic/lumbar) with a mean follow-up of 4.1 ± 1.6 years at which point 85% (90/106) had reached skeletal maturity. Preoperatively, these patients were skeletally immature (age: 12.8 ± 1.3 yr, Sanders: 3.3 ± 0.8, R = 0.6 ± 0.9) with a lumbar coronal curve angle of 49.6° ± 11.2° which corrected to 19.9° ± 11.2° (P < 0.0001) at most recent follow-up. At the latest follow-up, 76.4% (81/106) of the patients harbored a coronal curve angle of <30°. Twenty patients (18.9%) underwent 23 reoperations, with overcorrection being the most common (10/23, 43%). Broken tethers led to reoperation in 3 instances (3/23, 13%). Six patients in the cohort needed a posterior spinal fusion (6/106, 5.4%).

Conclusions.
Vertebral body tethering is a viable treatment option for skeletally immature patients with idiopathic scoliosis. This report is the largest to date for lumbar AVBT, highlighting that 84% of patients harbored a curve <35° at the latest follow-up but with an 18.9% reoperation rate.

Level of Evidence.
3.
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD
Authors: Murphy William A. , Diehl Anna Mae , Loop Matthew Shane , Fu Dong , Guy Cynthia D. , Abdelmalek Manal F. , Karachaliou Georgia Sofia , Sjöstedt Noora , Neuhoff Sibylle , Honkakoski Paavo , Brouwer Kim L. R. 
Published: February 2024

Background:
NAFLD is highly prevalent with limited treatment options. Bile acids (BAs) increase in the systemic circulation and liver during NAFLD progression. Changes in plasma membrane localization and zonal distribution of BA transporters can influence transport function and BA homeostasis. However, a thorough characterization of how NAFLD influences these factors is currently lacking. This study aimed to evaluate the impact of NAFLD and the accompanying histologic features on the functional capacity of key hepatocyte BA transporters across zonal regions in human liver biopsies.

Methods:
A novel machine learning image classification approach was used to quantify relative zonal abundance and plasma membrane localization of BA transporters (bile salt export pump [BSEP], sodium-taurocholate cotransporting polypeptide, organic anion transporting polypeptide [OATP] 1B1 and OATP1B3) in non-diseased (n = 10), NAFL (n = 9), and NASH (n = 11) liver biopsies. Based on these data, membrane-localized zonal abundance (MZA) measures were developed to estimate transporter functional capacity.

Results:
NAFLD diagnosis and histologic scoring were associated with changes in transporter membrane localization and zonation. Increased periportal BSEPMZA (mean proportional difference compared to non-diseased liver of 0.090) and decreased pericentral BSEPMZA (−0.065) were observed with NASH and also in biopsies with higher histologic scores. Compared to Non-diseased Liver, periportal OATP1B3MZA was increased in NAFL (0.041) and NASH (0.047). Grade 2 steatosis (mean proportional difference of 0.043 when compared to grade 0) and grade 1 lobular inflammation (0.043) were associated with increased periportal OATP1B3MZA.

Conclusions:
These findings provide novel mechanistic insight into specific transporter alterations that impact BA homeostasis in NAFLD. Changes in BSEPMZA likely contribute to altered BA disposition and pericentral microcholestasis previously reported in some patients with NAFLD. BSEPMZA assessment could inform future development and optimization of NASH-related pharmacotherapies.
Celastrol promotes apoptosis of breast cancer MDA-MB-231 cells by targeting HSDL2
Authors: Liu Li , Liu Yanqing , Zhang Shujie , Zhang Junzhe , Meng Yuqing , Liu Dandan , Gu Liwei , Zhang Ying , Xu Liting , Zhang Ziyue , Zhao Minghong , Wong Yinkwan , Wang Qixin , Zhu Yongping , Wang Jigang 
Published: February 2024

Objective:
Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicinal herb, Tripterygium wilfordii. This study aimed to provide a scientific basis for the rational development and use of celastrol in breast cancer.

Methods:
A quantitative chemical biology approach was used to investigate the protein targets and molecular mechanisms of celastrol in breast cancer cells.

Results:
Low-concentration celastrol exerted an anti-tumor effect by directly binding to hydroxysteroid dehydrogenase-like 2 (HSDL2) and inhibiting its expression. Moreover, the expression of the pro-apoptotic protein, BaX, increased, the level of the anti-apoptotic protein, Bcl-2, decreased, and the rate of apoptosis increased. After the transfection of cells with si-HSDL2, the apoptosis rate was similar to that observed after the administration of celastrol. However, apoptosis was reversed by the overexpression of HSDL2. Furthermore, our MS (Mass Spectrometry) data indicated a relationship between HSDL2 and the MAPK signaling pathway. We also found that the expression of HSDL2 was directly related to the degree of ERK phosphorylation.

Conclusions:
Celastrol may promote apoptosis by suppressing the HSDL2/ MAPK/ERK signaling pathway.
Examining neoadjuvant treatment candidates in resectable pancreatic cancer based on tumor-vessel interactions and CA 19-9 levels: A retrospective cohort study
Authors: Jung Hye-Sol , Han Youngmin , Yun Won-Gun , Cho Young Jae , Lee Mirang , Lee Dong Ho , Kwon Wooil , Jang Jin-Young 
Published: February 2024

Introduction:
The applicability of neoadjuvant treatment (NAT) for resectable pancreatic ductal adenocarcinoma (PDAC) has arisen, however, high-level evidence is lacking. This study aimed to explore patient subgroups with high-risk resectable PDAC for selecting candidates who may benefit from NAT.

Methods:
The 1,132 patients with resectable or borderline resectable PDAC who underwent surgery between 2007 and 2021 were retrospectively reviewed. Patients with resectable PDAC without contact of major vessels (R-no contact) (n=651), with contact of portal vein or superior mesenteric vein (PV/SMV) ≤180° (R-contact) (n=306), and borderline resectable PDAC without arterial involvement (BR-V) (n=175) were analyzed.

Results:
The mean age was 64.3 ± 9.8 years, and 647 patients (57.2%) were male. The median follow-up was 26 months in the entire cohort. Patients with resectable PDAC without vascular contact had the most improved overall survival (OS) (median; 31.5 months). OS did not significantly differ between NAT and upfront surgery in the entire resectable PDAC cohort. However, in R-contact group, NAT showed significantly improved OS compared to upfront surgery (33 vs. 23 months). Neoadjuvant FOLFIRINOX was showed a better OS than gemcitabine-based regimens in patients who underwent NAT (34 vs. 24 months). NAT was associated with a better survival in the patients with CA 19-9 level ≥150 U/mL, only when the tumor has PV/SMV contact in resectable disease (40 vs. 19 months, P = 0.001).

Conclusions:
NAT can be considered as an effective treatment in patients with resectable PDAC, particularly when the tumor is in contact with PV/SMV and CA 19-9 ≥150 U/mL.
Saw Palmetto Treatment for Prostatitis: A Systematic Review of the Literature
Authors: Punyala Ananth , Sze Christina , Winograd Joshua , Codelia-Anjum Alia , Morfin Montes de Oca Ernesto , Lee Maria , Bjohani Naeem , Elterman Dean , Zorn Kevin C. , Chughtai Bilal 
Published: February 2024

Purpose:
This systematic review was conducted to determine the safety and efficacy of Serenoa repens extract (saw palmetto extract) in treating chronic prostatitis, as compared with existing treatment regimens and placebo.

Methods:
Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic query was performed across multiple databases in December 2021 to identify relevant studies. The selection criteria focused on studies evaluating the treatment regimens, safety, and efficacy of saw palmetto in treating chronic prostatitis/chronic pelvic pain syndrome.

Results:
Of 259 references, 21 studies encompassing 1666 patients were selected. These studies included a range of trial types, with a mean follow-up period of approximately 6.975 months. Saw palmetto extract showed improved symptom relief compared with placebo, with mixed results when compared with alpha-blockers or 5-ARIs. Multimodal treatments, especially those including saw palmetto extract alongside antibiotics, displayed better efficacy in managing both Category II and Category III prostatitis.

Conclusion:
Saw palmetto extract provides symptom relief in patients with chronic prostatitis. Although monotherapy exhibited certain benefits over placebo, its best efficacy was observed when integrated into multimodal treatment regimens, particularly with antibiotics for Category II prostatitis. Future research may unveil specific adjuncts that enhance the therapeutic outcomes of regimens containing saw palmetto extract.
Evidence-based simulation: Fostering competency through structured and multisource feedback
Authors: Burt Leah , Fitz Sarah , Kiser Bob 
Published: February 2024

ABSTRACT
Preclinical simulation is an evidence-based method for nurse practitioner (NP) students to improve clinical communication and disease management competency. During simulation, students may receive feedback from multiple sources, including standardized patients (SPs), faculty, peers, and themselves. Although evidence supports simulation with multisource feedback, its impact on clinical knowledge and communication has yet to be evaluated among NP students. We designed, implemented, and evaluated a preclinical simulation program with structured multisource feedback integrated into a disease management course within a Doctor of Nursing Practice curriculum. Differences in communication self-efficacy and disease management knowledge before and after participation, as well as perceptions of learning and importance of varying feedback sources, were evaluated using a single group pre–post mixed-methods design. On average, clinical communication self-efficacy was significantly higher, and disease management knowledge scores were significantly higher after participation. Learners rated feedback sources as important or very important and described varying feedback sources as complementary. Feedback from SPs, peers, learners themselves, and faculty was complementary and important to learning. This preclinical simulation program with purposeful integration of multisource feedback provides an evidence-based foundation for scaffolding multidomain competency development into curriculums to meet updated standards of advanced nursing education.
Predisposing Factors for Postoperative Complications in the Year Following Fronto-Orbital Advancement and Remodeling: A Single Institution Study of 267 Patients
Authors: Wietlisbach Larissa E. , Barrero Carlos E. , Villavisanis Dillan F. , Swanson Jordan W. , Bartlett Scott P. , Taylor Jesse A. 
Published: February 2024

Background:
Fronto-orbital advancement and remodeling (FOAR) is a common surgical approach used for craniosynostosis conferring functional and aesthetic benefit. There are few reports examining predisposing factors for postoperative complications within the first year after surgery. This study aimed to establish complication rates and identify risk factors for inferior outcomes in a large population of patients undergoing FOAR.

Methods:
All patients who underwent fronto-orbital advancement and remodeling from 2013-2022 at our institution were retrospectively studied. Perioperative and postoperative data were collected to yield outcomes analyses. Multivariable logistic regression with backwards selection was performed to identify predictors of postoperative complications.

Results:
267 patients underwent FOAR. The overall complication rate was 14.2%, most commonly delayed wound healing (7.4%), postoperative blood transfusion (5.8%), and infection requiring readmission (1.9%). Tense closure independently predicted delayed wound healing (p<0.001) and infection requiring readmission (p=0.03). Syndromic patients were more likely than non-syndromic children to have undergone prior craniofacial surgery (45.3% vs 23.8%, p=0.003). Syndromic status and prior craniofacial surgery were associated with increased risk of developing infection requiring readmission (p=0.012 and p=0.004, respectively). A greater proportion of malnourished patients experienced postoperative complications compared to patients without malnourishment (24.4% vs 12.1%, p=0.031), though there were no significant differences in individual postoperative outcomes.

Conclusions:
Identified risk factors for complications included syndromic status, tense closure, and prior craniofacial surgery. Most complications were managed nonoperatively. These factors may be considered in preoperative planning and when counseling patient families.
Cutaneous Metastasis of Ovarian Cancer on 68Ga-FAPI PET/CT
Authors: Ding Haoyuan , Li Dan , Chen Yue , He Wenfeng , Cai Liang 
Published: February 2024

Abstract
Ovarian cancer with cutaneous metastases is quite rare. We report the findings of cutaneous metastases from ovarian cancer on 68Ga-FAPI PET/CT imaging. A 53-year-old woman with cutaneous metastases from ovarian cancer was enrolled in 68Ga-FAPI PET/CT clinical trial. The images showed intense FAPI activity in the known cutaneous metastases.
Comparison of 18F-FAPI and 18F-FDG PET/CT in a Patient With Fibrous Dysplasia
Authors: Mu Xingyu , Li Zuguo , Qin Jie , Wang Zhenzhen , Fu Wei 
Published: February 2024

Abstract
A 16-year-old woman presented with an acute headache on the left side. A head CT scan revealed bone destruction in the skull. Subsequent 18F-FDG and 18F-FAPI PET/CT scans were performed within a week. The 18F-FDG PET/CT indicated mild uptake in the regions of bone destruction, whereas the 18F-FAPI PET/CT displayed significant tracer accumulation. The patient was ultimately diagnosed with fibrous dysplasia.
Eosinophilic Fasciitis Illustrated by 18F-FDG PET/CT
Authors: Fevrier Agathe , Dufour Pierre-Alban 
Published: February 2024

Abstract
Eosinophilic fasciitis is a rare sclerodermiform disease characterized by upper and lower limb edema. We present the case of a 71-year-old woman currently hospitalized for painful lower limb edema. Laboratory tests reveal moderate eosinophilia (0.8 g/L) and an inflammatory syndrome. Abdominopelvic ultrasound reveals no abnormalities. In light of the unexplained inflammatory syndrome, a 18F-FDG PET/CT scan currently shows intense hypermetabolism of the fasciae in the lower and upper limbs. Following an MRI, a biopsy is performed, and the anatomopathology currently confirms eosinophilic fasciitis.
FDG PET/CT in a Case of Isolated Gastric Metastasis From Pancreatic Ductal Adenocarcinoma
Authors: Ji Xia , Dong Aisheng , Wang Yang 
Published: February 2024

Abstract
Hematogenous gastric metastasis from pancreatic cancer is extremely rare. We describe FDG PET/CT findings in a case of isolated hematogenous gastric metastasis from pancreatic cancer with significantly elevated serum carbohydrate antigen 19-9 level. The gastric metastasis showed intense focal FDG uptake mimicking a primary tumor. The elevation of serum carbohydrate antigen 19-9 level may be useful as an aid in the differential diagnosis.
99mTc-HYNIC-FAPI-46 SPECT/CT Uptake in Lactating Breasts
Authors: Hadad Bentolhoda , Aryana Kamran , Kamali Hassan , Askari Emran 
Published: February 2024

Abstract
A 36-year-old woman with a history of medullary thyroid carcinoma was referred for 99mTc-HYNIC-FAPI-46 scan. Her calcitonin levels gradually increased after external beam radiation therapy, whereas her CEA levels were stable. A few suspicious tumoral lymphadenopathies were localized to the superior mediastinum. Interestingly, bilateral physiologic breast uptake was noticed, which was presumed to be due to lactation in the past 18 months. To our knowledge, physiologic breast uptake in 99mTc-HYNIC-FAPI imaging has not been previously reported.
Small Cell Neuroendocrine Carcinoma of the Prostate on 18F-DCFPyL and 18F-FDG PET/CT
Authors: Li Edward , Russon Andrew , Chen Jeffrey , Mansberg Victor , Mansberg Robert 
Published: February 2024

Abstract
A 51-year-old man with newly diagnosed small cell neuroendocrine carcinoma of the prostate was referred for a staging 18F-DCFPyL PET/CT, which showed a solitary metastasis in the left acetabulum. Subsequent 18F-FDG PET/CT showed intense uptake throughout the prostate as well as extensive avid pelvic and thoracic nodal disease and redemonstration of the left acetabular metastasis. Despite initial metabolic response to treatment, subsequent 18F-FDG PET 8 months later revealed significant progression of nodal disease above and below the diaphragm, as well as multiple new sites of metastases.
Diffuse Bone Uptake of 131I and Effect on Blood Counts in a Patient With Papillary Thyroid Carcinoma and Chronic Lymphocytic Leukemia
Authors: Latgé Adrien , Krim Mehdi , Vija Lavinia , Ysebaert Loïc , Zerdoud Slimane 
Published: February 2024

Abstract
A 57-year-old woman with history of chronic lymphocytic leukemia was referred to our center for adjuvant 131I therapy following complete thyroidectomy for differentiated thyroid cancer. Posttherapeutic scintigraphy revealed atypical diffuse osteomedullar uptake. A major drop in lymphocyte count was observed, from 117.7 g/L to 4.8 g/L 8 weeks after 131I therapy. Bone marrow uptake is presumed to be related to tracer sequestration in leukemic cells. White blood cell count normalization suggests a high sensitivity of leukemic cells to beta emission. This scintigraphic pattern may act as a pitfall for nuclear medicine physician.