bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrinsic ureteric obstruction secondary to endometriosis: a rare clinical entity causing obstructive uropathy and renal failure
Authors: Anton Sagayanathan Prasanth , Goai Xin Yi , Loganathan Ajanthan , Pridgeon Simon 
Published: February 2024

Ureteral endometriosis is rare and can be a silent clinical entity, which can potentially lead to serious complications such as obstructive uropathy, sepsis and renal failure. A high clinical suspicion is required especially in childbearing age groups due to non-specific presentation such as renal colic, recurrent urinary tract infection (UTI), renal failure or asymptomatic hydronephrosis.A woman in her 40s presented with febrile UTI and flank pain. She reportedly suffered from recurrent UTIs in the past. Initial workup revealed an infected, obstructed left renal collecting system with gross hydronephrosis and hydroureter to the distal ureter on a significant gynaecological background of severe endometriosis requiring hysterectomy in the past.CT showed chronic obstructive changes and soft tissue nodules within the renal pelvis with no radio-opaque stones. She underwent emergent ureteric stent insertion. Functional imaging demonstrated only 1% contribution of the left kidney with a preserved estimated glomerular filtration rate of 65 mL/min/1.73 m2.Endoscopic evaluation of ureters found extensive soft tissue lesions throughout the dilated left collecting system with biopsy-confirmed endometriosis. Subsequently, she underwent laparoscopic nephroureterectomy due to extensive ureteric involvement and chronically obstructed non-functioning kidney. Histopathology demonstrated completely obstructing ureteral endometriosis.Ureteric obstruction secondary to endometriosis can be due to extrinsic or intrinsic disease. In addition to initial assessment with CT urogram MRI may be helpful to evaluate soft tissue thickening. Endoscopic assessment with ureteroscopy and biopsy is required for tissue diagnosis. Surgery is often the treatment of choice, ranging from ureteroureterostomy, ureteroneocystostomy or nephroureterectomy in severe cases.Ureteral endometriosis is a rare clinical entity, clinicians should remain vigilant about common presentations of this rare entity, early diagnosis and prompt treatment is crucial to prevent progression to renal failure.
Enhanced prediction of abnormal glucose tolerance using an extended non-invasive risk score incorporating routine renal biochemistry
Authors: He Jie , Fan Baoqi , Lau Eric S H , Chu Natural , Ng Noel Yat Hey , Leung Kathy Ho Ting , Poon Emily W M , Kong Alice Pik Shan , Ma Ronald Ching Wan , Luk Andrea O Y , Chan Juliana C N , Chow Elaine 
Published: February 2024

IntroductionType 2 diabetes is preventable in subjects with impaired glucose tolerance based on 2-hour plasma glucose (2hPG) during 75 g oral glucose tolerance test (OGTT). We incorporated routine biochemistry to improve the performance of a non-invasive diabetes risk score to identify individuals with abnormal glucose tolerance (AGT) defined by 2hPG≥7.8 mmol/L during OGTT.Research design and methodsWe used baseline data of 1938 individuals from the community-based “Better Health for Better Hong Kong - Hong Kong Family Diabetes Study (BHBHK-HKFDS) Cohort” recruited in 1998–2003. We incorporated routine biochemistry in a validated non-invasive diabetes risk score, and evaluated its performance using area under receiver operating characteristics (AUROC) with internal and external validation.ResultsThe AUROC of the original non-invasive risk score to predict AGT was 0.698 (95% CI, 0.662 to 0.733). Following additional inclusion of fasting plasma glucose, serum potassium, creatinine, and urea, the AUROC increased to 0.778 (95% CI, 0.744 to 0.809, p<0.001). Net reclassification improved by 31.9% (p<0.001) overall, by 30.8% among people with AGT and 1.1% among people without AGT. The extended model showed good calibration (χ2=11.315, p=0.1845) and performance on external validation using an independent data set (AUROC=0.722, 95% CI, 0.680 to 0.764).ConclusionsThe extended risk score incorporating clinical and routine biochemistry can be integrated into an electronic health records system to select high-risk subjects for evaluation of AGT using OGTT for prevention of diabetes.
No scalar-haired Cauchy horizon theorem in charged Gauss–Bonnet black holes
Authors: Devecioğlu Deniz O. , Park Mu-In 
Published: February 2024

AbstractRecently, a “no inner (Cauchy) horizon theorem” for static black holes with non-trivial scalar hairs has been proved in Einstein–Maxwell–scalar theories and also in Einstein–Maxwell–Horndeski theories with the non-minimal coupling of a charged (complex) scalar field to Einstein tensor. In this paper, we study an extension of the theorem to the static black holes in Einstein–Maxwell–Gauss–Bonnet-scalar theories, or simply, charged Gauss–Bonnet (GB) black holes. We find that no inner horizon with charged scalar hairs is allowed for the planar ($$k=0$$

k
=
0

) black holes, as in the case without GB term. On the other hand, for the non-planar ($$k=\pm 1$$

k
=
±
1

) black holes, we find that the haired inner horizon can not be excluded due to GB effect generally, though we can not find a simple condition for its existence. As some explicit examples of the theorem, we study numerical GB black hole solutions with charged scalar hairs and Cauchy horizons in asymptotically anti-de Sitter space, and find good agreements with the theorem. Additionally, in an Appendix, we prove a “no-go theorem” for charged de Sitter black holes (with or without GB terms) with charged scalar hairs in arbitrary dimensions.
Constraints on Lorentz violation parameter through electric dipole moments
Authors: Aghababaei Sarah 
Published: February 2024

AbstractThe electric dipole moments of leptons (l-EDMs) could arise from the electrodynamics part of standard model extension (SME). In this work, we investigate the cross section of electron-positron collision in the Lorentz violation (LV) background via the l-EDMs. We find that the Lorentz violation parameter magnitudes constraint using LEP data to the level of $$|d^{e}_{LV}| < 3.6 \times 10^{-17} $$

|

d

LV

e

|
<
3.6
×

10

-
17

, $$ |d^{\mu }_{LV}|< 9.5 \times 10^{-10} $$

|

d

LV

μ

|
<
9.5
×

10

-
10

, and $$ |d^{\tau }_{LV}|< 1.5 \times 10^{-6} $$

|

d

LV

τ

|
<
1.5
×

10

-
6

for electron, muon, and tau, respectively. Moreover, we show the time-location dependence of muon-EDMs and tau-EDMs in the LV background. Therefore, upper bounds for combinations of LV parameters are obtained by current and future terrestrial experiments.
Unraveling the Therapeutic Benefit of Sequenced Chemo-immunotherapy
Authors: Vignali Paolo D.A. , Luke Jason J. 
Published: February 2024

SummaryCombination immune-checkpoint inhibition with chemotherapy is a clinical standard, yet concurrent administration may limit the full benefit of immunotherapy by blunting the proliferation and differentiation of CD8 T cells. Identifying patients in whom sequential chemo-immunotherapy or immunotherapy alone is feasible should be a priority to optimize long-term outcomes.See related article by Mariniello et al., p. 1833
FIGURE 2 from Anti-Vα24Jα18 TCR Antibody Tunes iNKT Cell Responses to Target and Kill CD1d-negative Tumors in an FcγRII (CD32)-dependent Manner
Authors: Takami Mariko , Aoki Takahiro , Nishimura Katsuhiro , Tanaka Hidekazu , Onodera Atsushi , Motohashi Shinichiro 
Published: February 2024

<p>6B11 mAb induces degranulation of iNKT cells toward K562 cells. PBMCs isolated from healthy donors were cultured in the presence of α-GalCer and IL2 for 9–10 days, followed by sorting using Vα24-FITC Ab/FITC MicroBeads. Sorted iNKT cells were maintained in the presence of IL2 overnight and then washed. iNKT cells were then maintained in the presence of IL2 until analysis. <b>A,</b> Sorted iNKT cells were maintained overnight and then the culture supernatant was collected. The culture supernatant depleted with anti-mouse Ig beads or the control was added to iNKT cell cultures overnight prior to coculture with K562 cells for the CD107a assay. <b>B,</b> Sorted iNKT cells treated with the 6B11 mAb (10, 50, and 100 ng/ mL) or isotype mAb (mIgG1, 50 ng/mL) were cocultured with K562 cells for CD107a assays. <b>C,</b> Sorted iNKT cells treated with the 6B11 mAb (50 ng/mL) or isotype mAb (50 ng/mL) were cocultured with K562 cells at E/T ratios of 10:1, 5:1, and 2.5:1. An LDH release assay was then performed. <b>D,</b> Sorted iNKT cells treated with the 6B11 mAb (50 ng/ mL) or isotype (mIgG1, 50 ng/mL) were cocultured with K562 cells. Culture supernatants were collected for Cytometric Bead Array to assess IFNγ and TNFα production. <b>E,</b> iNKT cells were treated with the 6B11 mAb and anti-CD3e (UCHT1), anti-CD28, anti-CD2, or isotype control Abs overnight. iNKT cells were then washed and cocultured with K562 cells. Data are representative of two independent experiments. Data represent the mean ± SEM. *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001; ****, <i>P</i> < 0.0001. HD, healthy donor.</p>
Aneurysmal Versus “Benign” Perimesencephalic Subarachnoid Hemorrhage
Authors: Alrohimi Anas , Davison Mark A. , Pandhi Abhi , Abdulrazzak Mohammad A. , Wadden Daniel , Bain Mark , Moore Nina , Hussain M. Shazam , Toth Gabor 
Published: February 2024

Background
The rate of underlying ruptured aneurysms, complications, and their relevance to outcomes in “benign” perimesencephalic subarachnoid hemorrhage are not well known and underreported.

Methods
Retrospective analysis of patients with perimesencephalic subarachnoid hemorrhage from a large tertiary care center (2007–2022).

Results

Eighty‐one patients were included with mean age of 55.5 ± 10.3 years. An underlying ruptured aneurysm was diagnosed in 5 patients (6.2%); 3 (60%) had negative computed tomography angiography and they were detected only in digital subtraction angiography (2 on initial digital subtraction angiography and 1 on follow‐up digital subtraction angiography). The most common complication was vasospasm in 25/81 patients (31%), and the majority 21/25 (84%) were asymptomatic. Symptomatic vasospasm occurred at a significantly higher rate among patients with underlying aneurysm (40% versus 2.6%;
P
= 0.01). Hydrocephalus occurred in 10% of patients, all within 1 day, but at a higher rate in the aneurysmal group (40% versus 8%;
P
= 0.07). A total of 88% of patients had modified Rankin scale score 0–2 at discharge, but at a significantly higher rate in nonaneurysmal patients (91% versus 40%;
P
= 0.01). An underlying aneurysm, hydrocephalus, and symptomatic vasospasm were associated with poor functional status (odds ratio [OR] = 14.7 [2.1–104];
P
= 0.007, OR = 22.6 [4.2–123.5];
P
<0.001, OR = 8.6 [1.06–69.88];
P
= 0.04), respectively.

Conclusion
“Benign” perimesencephalic subarachnoid hemorrhage pattern was associated with a ruptured aneurysm in 6.2% of patients, and 3.7% were detected only on cerebral angiogram. Underlying aneurysm, symptomatic vasospasm, and hydrocephalus were associated with lower rates of good clinical outcome. All hydrocephalus cases were symptomatic and occurred very early. Asymptomatic vasospasm alone was not associated with poor outcomes. Our findings suggest that patients with nonaneurysmal perimesencephalic subarachnoid hemorrhage without hydrocephalus can safely be managed with less strict monitoring and a shorter hospital stay.
The prevalence and distribution of risk factors for depression and emotional mental disorders in the elderly in Indonesia
Authors: Wardhani Yurika Fauzia , Nantabah Zainul Khaqiqi , Machfutra Eka Denis , Lestyoningrum Sinta Dewi , Oktarina  , Nurjana Made Agus 
Published: February 2024

Background: Depression is a mental health disorder. The prevalence of mental health disorders in the elderly is high. Aims: This study was to determine the mental status depression and emotional of the elderly based on their characteristics. Methods: This study was a further analysis of Basic Health Research 2018 data. The population was all households from all districts/cities in 33 provinces in Indonesia with a cross-sectional design. The sample was all elderly, with a total sample of 82,304,000 people. The respondents included young elderly (60–69 years), middle elderly (70–79 years), and old elderly (>80 years). Result: Depression is experienced by most of elderly aged 60 to 69 years as many as 3,756,384 respondents (59.72%), females as many as 3,885,191 respondents (61.77%), living in urban areas, as many as 3,147,131 respondents (50.03%), graduated from elementary school as many as 2,052,22 respondents (32.63%), not working as many as 3,535,241 respondents (56.21%), and quintile one expenditure level as many as 1,532,358 respondents (24.36%). Conclusions: Emotional disorders of depression in elderly are due to the adaptation process to physical and psychosocial changes. Family support is a must to improve elderly’s quality of life on mental health aspects, especially depression. Furthermore, better treatment by medical personnel is required.
Are sesamoids and proximal phalanx of metatarsus primus varus deformity of hallux valgus feet displaced? A radiological study
Authors: Wu Daniel Yiang , Lam Eddy Kwok Fai 
Published: February 2024

Background The hallux valgus deformity is made up of misaligned first metatarsal, hallux, and sesamoids. Their angular deformities are well-studied, but not their positional displacements. A few available reports claimed the proximal end of the proximal phalanx and sesamoids were not shifted medially along with the first metatarsal head. However, the general observation is otherwise. This study revisits the issue. Methods A radiological study of 189 feet with and without the hallux valgus deformity was carried out to analyze the first metatarsal, hallux, and sesamoid positional changes in relation to the second metatarsal and among themselves. A total of 194 X-ray images with all relevant measurements that formed the raw database for this study were submitted for online viewing and reference. Results There was a statistically significant change in the first metatarsal, hallux, and sesamoid positions of feet with hallux valgus deformity compared to normal feet. All have migrated medially but to different degrees. It was contrary to the past findings of no change in sesamoid and hallux positions. Conclusions We agree with past findings that the metatarsus primus varus deformity is directly related to the failed medial metatarsosesamoid ligament. We also believe in the failure of the deep 1-2 transverse metatarsal ligament responsible for the sesamoid migration.
Global trends and outcomes of nerve transfers for treatment of adult brachial plexus injuries
Authors: Crowe Christopher S. , Spinner Robert J. , Shin Alexander Y. 
Published: February 2024

The presentation, management and outcomes of brachial plexus injuries are likely to be subject to regional differences across the globe. A comprehensive literature search was performed to identify relevant articles related to spinal accessory to suprascapular, intercostal to musculocutaneous, and ulnar and/or median nerve fascicle to biceps and/or brachialis motor branch nerve transfers for treatment of brachial plexus injuries. A total of 6007 individual brachial plexus injuries were described with a mean follow-up of 38 months. The specific indication for accessory to suprascapular and intercostal to musculocutaneous transfers were considerably different among regions (e.g. upper plexus vs. pan-plexal), while uniform for fascicular transfer for elbow flexion (e.g. upper plexus +/− C7). Similarly, functional recovery was highly variable for accessory to suprascapular and intercostal to musculocutaneous transfers, while British Medical Research Council grade ≥3 strength after fascicular transfer for elbow flexion was frequently obtained. Overall, differences in outcomes seem to be inherent to the specific transfer being utilized. Level of evidence: III
Nomenclature of the ancylite supergroup
Authors: Wang Yanjuan , Nestola Fabrizio , Hou Zengqian , Miyawaki Ritsuro , Pekov Igor V. , Gu Xiangping , Dong Guochen , Qu Kai 
Published: February 2024

Abstract
The ancylite supergroup has been approved by the Commission on New Minerals, Nomenclature and Classification of the International Mineralogical Association, with the general crystal chemical formula (M3+
x
M2+2–x)(CO3)2[(OH)
x
⋅(2–x)H2O] (1 ≤ x ≤ 2, Z = 2). The ancylite supergroup can be divided into two groups defined by different proportions of the M cation and hydroxyl anion and/or water molecule: the ancylite group is defined for 1 ≤ x ≤ 1.5; the kozoite group is defined for 1.5 < x ≤ 2. The ancylite supergroup minerals are orthorhombic with space group Pmcn, or monoclinic with space group Pm11, and have a crystal structure with species-defining trivalent and divalent M cations (M = La3+, Ce3+, Nd3+, Ca2+, Sr2+ and Pb2+) which centre ten-vertex polyhedra formed by oxygen atoms at three independent O sites. Two vertices of the triangular (CO3)2– anion are oxygen atoms, whereas the third one, O(3), is statistically filled with (OH)– groups and H2O molecules. The triangular faces of three oxygen atoms of MO10 coordination polyhedra join the chains of this ten-vertex polyhedron, which is extended along the c axis. The (CO3) triangles connect chains in three dimensions. To date, eight valid mineral species with M2+ = Sr2+, Ca2+ and Pb2+ belong to the ancylite group [ancylite-(La), ancylite-(Ce), calcioancylite-(La), calcioancylite-(Ce), calcioancylite-(Nd), gysinite-(La), gysinite-(Ce) and gysinite-(Nd)]. Two hydroxyl carbonates with only rare earth elements as species-defining cations, kozoite-(La) and kozoite-(Nd) are members of the kozoite group.
Overview of best practices for buprenorphine initiation in the emergency department
Authors: Hughes Terence , Nasser Nicholas , Mitra Avir 
Published: February 2024

AbstractIn recent decades, opioid overdoses have increased dramatically in the United States and peer countries. Given this, emergency medicine physicians have become adept in reversing and managing complications of acute overdose. However, many remain unfamiliar with initiating medication for opioid use disorder such as buprenorphine, a high-affinity partial opioid agonist. Emergency department-based buprenorphine initiation is supported by a significant body of literature demonstrating a marked reduction in mortality in addition to increased engagement in care. Buprenorphine initiation is also safe, given both the pharmacologic properties of buprenorphine that reduce the risk of diversion or recreational use, and previously published literature demonstrating low rates of respiratory depression, sedation, and precipitated withdrawal. Further, barriers to emergency department-based initiation have been reduced in recent years, with publicly available dosing and up-titration schedules, numerous publications overviewing best practices for managing precipitated withdrawal, and removal of USA policies previously restricting patient access and provider prescribing, with the removal of the X-waiver via the Medication Access and Training Expansion Act. Despite reductions in barriers, buprenorphine initiation in the emergency room remains underutilized. Poor uptake has been attributed to numerous individual and systemic barriers, including inadequate education, provider stigma, and insufficient access to outpatient follow-up care. The following practice innovation aims to summarize previously published evidence-based best practices and provide an accessible, user-friendly initiation guide to increase emergency physician comfortability with buprenorphine initiation going forward.
Genome-wide identification and structural analysis of the BMP gene family in Triplophysa dalaica
Authors: Zhang Yizheng , Yu Jinhui , Han Rui , Ma Zhigang , Zhang Meng , Li Yikai , Tang Yongtao , Nie Guoxing , Zhou Chuanjiang 
Published: February 2024

Abstract
Background
Bone morphogenetic proteins (BMPs) are part of the transforming growth factor beta (TGF-β) superfamily and play crucial roles in bone development, as well as in the formation and maintenance of various organs. Triplophysa dalaica, a small loach fish that primarily inhabits relatively high elevations and cooler water bodies, was the focus of this study. Understanding the function of BMP genes during the morphogenesis of T. dalaica helps to clarify the mechanisms of its evolution and serves as a reference for the study of BMP genes in other bony fishes. The data for the T. dalaica transcriptome and genome used in this investigation were derived from the outcomes of our laboratory sequencing.

Results
This study identified a total of 26 BMP genes, all of which, except for BMP1, possess similar TGF-β structural domains. We conducted an analysis of these 26 BMP genes, examining their physicochemical properties, subcellular localization, phylogenetic relationships, covariance within and among species, chromosomal localization, gene structure, conserved motifs, conserved structural domains, and expression patterns. Our findings indicated that three BMP genes were associated with unstable proteins, while 11 BMP genes were located within the extracellular matrix. Furthermore, some BMP genes were duplicated, with the majority being enriched in the GO:0008083 pathway, which is related to growth factor activity. It was hypothesized that genes within the BMP1/3/11/15 subgroup (Group I) play a significant role in the growth and development of T. dalaica. By analyzing the expression patterns of proteins in nine tissues (gonad, kidney, gill, spleen, brain, liver, fin, heart, and muscle), we found that BMP genes play diverse regulatory roles during different stages of growth and development and exhibit characteristics of division of labor.

Conclusions
This study contributes to a deeper understanding of BMP gene family member expression patterns in high-altitude, high-salinity environments and provides valuable insights for future research on the BMP gene family in bony fishes.