bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potential of preoperative three-dimensional computed tomography for para-aortic lymphadenectomy in gynecological malignancies
Authors: Yanazume Shintaro , Ejima Fumitaka , Kobayashi Yusuke , Kozai Ayumi , Fukuda Mika , Togami Shinichi , Yoshiura Takashi , Kobayashi Hiroaki 
Published: February 2025

Abstract

Background
The evaluation of anatomical abnormalities involving urinary vessel variations prior to para-aortic lymphadenectomy in gynecological malignancies is challenging. In this context, the utility of preoperative three-dimensional (3D) computed tomography (3DCT) angiography in improving surgical outcomes was examined.
Methods
This observational study evaluated the utility of 3DCT in patients who underwent para-aortic lymphadenectomy between January 2023 and November 2024. 3D fusion images were constructed from the arterial phase (CTA), CT-venography (CTV), and CT-urography (CTU). A total of 72 patients were included and divided into two groups: Non-3DCT and 3DCT. Outcomes included detection rates of arterial, venous, or urinary tract variations and surgical outcomes, including complications, in both groups.
Results
The 3DCT group included 14/34 (41.2%) cases with renal vessel variations and two cases (5.9%) with double ureters; the non-3DCT group did not detect any anatomical abnormalities. In the 3DCT group, renal vessel and urinary tract variations were clearly shown. Postoperative complications tended to be slightly higher in the non-3DCT group, including lymphocyte infection, chylous leakage, and bowel obstruction. Postoperative CT revealed reduced contrast in the lower pole of the right kidney in the 3DCT case with the most complex urinary vessel variations. Furthermore, in the 3DCT group, 8/34 (23.5%) unilateral or bilateral renal arteries were located caudally to the lower edge of the renal vein.
Conclusion
In gynecological malignancies, 3DCT before para-aortic lymphadenectomy was superior in identifying urinary vessel variations over conventional contrast-enhanced CT; thus, aiding realistic preoperative simulations and potentially reducing surgeons' burden and perioperative complications.
Unmet supportive care needs in patients with advanced cancer and its impact on distress
Authors: Miranda Kayla W. , Musher Benjamin L. , Badr Hoda J. 
Published: February 2025

Abstract

Purpose Patients with advanced cancer endure considerable physical and emotional distress without sufficient supportive care. In order to identify areas for intervention, this cross-sectional study examined the relationship between cancer-related symptoms, supportive care needs, and distress levels in patients with advanced lung, head and neck, or gastrointestinal cancers.Methods Baseline data from 158 patients enrolled in a multisite dyadic interventional study were analyzed using the M.D. Anderson Symptom Inventory (MDASI) and Supportive Care Needs Survey (SCNS-34). Pearson correlations and multiple regression analyses were used to explore associations between supportive care needs and distress.Results Distress levels were moderate across the study population, with fatigue, pain, and disturbed sleep being the most reported symptoms. Patients who lived with their caregivers reported significantly lower needs in four out of five domains. Positive correlations were found between distress levels and supportive care needs in the psychological (p < 0.001), health system (p = 0.001), patient care and support (p = 0.003), and physical and daily living domains (p < 0.001). Multiple regression analysis showed that these domains collectively explained a significant portion of the variance in distress levels (R2 = 0.169, p < 0.001).Conclusion Independent of demographic or clinic characteristics, patients with advanced cancer experience significant distress and unmet supportive care needs, particularly in psychological and health system domains. The association between living with caregivers and lower reported needs suggests that caregiver support may play a crucial role in meeting these needs. Therefore, integrating strategies that involve and support caregivers could potentially reduce distress and improve the quality of life for patients with advanced cancer.
Parietotemporal atypical teratoid/rhabdoid tumor (ATRT) in a 5 years old male: A Case Report
Authors: Malhes Waleed , Abualrub Ahmad , Shehadeh Mohammad , Alomari Fadi , Dababseh Hadi , Abulihya Mohanad 
Published: February 2025

Abstract

Background
Atypical teratoid/rhabdoid tumor (AT/RT) is a rare and highly aggressive embryonal tumor of the central nervous system (CNS), primarily affecting children under three years of age. Characterized by rapid growth and dissemination, AT/RT has a poor prognosis, with median survival times often measured in months. Recent advances in treatment, including autologous stem cell transplantation (ASCT), aim to improve outcomes but lack a definitive protocol.
Case Presentation
: We report a case of a 5-year-old male presenting with acute left-sided weakness, right-sided mouth deviation, and confusion. Initial imaging at another facility revealed a right parietotemporal intra-axial lesion with significant edema and midline shift. Upon transfer to our institution, Magnetic resonance imaging (MRI) confirmed a large supratentorial mass involving critical structures without invasion of major arteries. Surgical intervention was necessary, and a right pterional craniotomy was performed for maximal safe resection. During surgery, the tumor was identified as grayish, highly vascularized, and necrotic. Successful debulking was achieved, with careful preservation of surrounding neural structures. Postoperatively, the patient demonstrated significant neurological improvement, with a Glasgow Coma Scale (GCS) score of 15/15. Histopathological examination confirmed the diagnosis of AT/RT, WHO grade 4, characterized by malignant blue cells and loss of INI1 immunoreactivity.
Conclusion
This case underscores the importance of early diagnosis and aggressive intervention in managing AT/RT. The complexities of its presentation and imaging necessitate a multidisciplinary approach, integrating neurosurgery and oncology. Our findings support the use of surgical resection, contemporary chemotherapy, and ASCT as part of a multimodal treatment strategy to enhance survival outcomes. However, the inherent aggressiveness of AT/RT highlights the urgent need for innovative treatments and further research to improve prognoses for affected patients.
Trends of Intimal Hyperplasia After Carotid Endarterectomy and Its Risk Factor Analysis
Authors: Liu Xiaozheng , Wu Xian , Jin Youhe , Lou Zhe , Liu Yuan 
Published: February 2025

Abstract

Background
In this study, we investigated the changes in carotid intimal hyperplasia and the growth rate over time after carotid endarterectomy (CEA). We also assessed and analyzed risk factors for intimal growth rate after CEA to strengthen secondary prevention and control early restenosis post-CEA.
Methods
We randomly selected 60 patients who underwent CEA from 2019 to 2021. The median follow-up duration was 6.4 (range, 3–32) months. Intimal thickness, intimal growth rate, vascular diameter, and blood flow velocity parameters were recorded postoperatively. Analysis of variance and logistic regression were used to analyze changes and risk factors of carotid intimal hyperplasia after CEA.
Results
Intimal thickness (1.44 ± 0.59 mm) gradually increased; growth rate (0.246 ± 0.165 mm/month) gradually decreased. Intimal growth rate quartiles were established as follows: 0.025–0.129, 0.129–0.204, 0.204–0.323, and 0.323–0.741 mm/month. The first and fourth quartiles differed for smoking history, plaque vulnerability, procedure (CEA with patch [pCEA]), and severe vertebral or subclavian arterial stenosis.
Conclusion
Intimal thickness gradually increased as the growth rate gradually decreased. The intimal growth rate was elevated in smokers, individuals with vulnerable plaque carriers, and patients exhibiting severe vertebral or subclavian arterial stenosis. The intimal growth rate was lower in patients who underwent pCEA. Plaque vulnerability constituted an independent risk factor for an elevated intimal growth rate.
Safe Steps: A Text Message Intervention to Increase Physical Activity After Emergency Department Discharge in Older Adults
Authors: Suffoletto Brian , Mayer Waverly , Toth Caitlin , Ashenburg Nick , Lin Michelle , Losak Michael , Kim David 
Published: February 2025

Abstract

Background: Older adults face increased risk of functional impairments after Emergency Department (ED) discharge, yet no evidence-based physical activity interventions exist for this population.
Objective: To evaluate the feasibility, safety, and effectiveness of Safe Steps, a text message intervention designed to increase daily step counts among older adults discharged from the ED.
Methods: In this single-center pilot study, we recruited ED patients aged ≥60 years reporting low physical activity (<7,500 steps/day OR <75 minutes/day walking). Participants received a pedometer and daily text messages to report steps and set weekly goals over 4 weeks. Feasibility was assessed via step count reporting rates, safety through fall monitoring, and effectiveness by changes in step counts.
Results: Forty-three participants enrolled; 40 completed the study. Step reporting rates were 87.2%. Three participants reported falls, none attributed to activity. Low-active participants (<5,000 steps) increased steps by 23.3%. Participants rated intervention motivation 7.4/10.
Conclusion: Safe Steps appears feasible, safe, and effective for promoting activity post-ED discharge, warranting further study.
Anatomic Study of the Deep Structures of the Cerebellum: Location of the Dentate Nucleus and Its Relationship with Surgical Approaches to Tumor Lesions
Authors: Paolinelli Pablo S. , Migliardo Camila B. , Cicler Julian , Colombo Axel , Trofa Valeria , Iglesias Valentin , Villamil Facundo 
Published: February 2025

Abstract

Introduction and Objectives: The cerebellum presents complex relationships, such as those with the structures of the cerebello pontine angle and a complex anatomy consisting of surfaces, lobes, lobules, peduncles, and nuclei. On this matter, the cerebellum is a challenging structure to approach which has important relationships that if not taken in account may lead to an injury and may not possibly reduce morbidity and mortality. Our objective is to present a system of anatomic and topographic landmarks to identify the dentate nucleus (DN) during the supracerebellar infratentorial approach.
Materials and Methods: Postmortem dissections were performed on 10 cerebella according to the Klingler technique.
Anatomy was observed and then a deep dissection was performed, identifying the peduncles and then the DN. Subsequently, the DN was delineated with four lines α, β, γ, and 𝞨, allowing to find the DN within 100% of cases. Finally, the number of times the nucleus was found within the quadrilateral was observed.
Results: The lobules of the vermis and hemispheres were identified on the tentorial and suboccipital surfaces, with the superior (SCP), middle (MCP), and inferior (ICP) cerebellar peduncles recognized on the tentorial surface and the MCP on the suboccipital surface. The DN was identified on both aspects.
Conclusion: There are no landmarks to locate the DN during surgery, our proposal of a quadrilateral that allows intraoperative localization of the nucleus reduce the morbidity and mortality of the surgery of the cerebellum
Double anastomoses between posterior cerebral artery and posterior communicating artery diagnosed by magnetic resonance angiography
Authors: Uchino Akira , Kondo Ryushi 
Published: February 2025

Abstract

Purpose
To describe a case of double anastomoses between the posterior cerebral artery (PCA) and the posterior communicating artery (PCoA).
Methods
An 83-year-old woman with left pulsatile tinnitus underwent cranial magnetic resonance angiography (MRA) using a 3-Tesla scanner. MRA was performed using a standard 3-dimensional time-of-flight technique.
Results
MRA showed no dural arteriovenous fistula; however, there was a stenotic lesion in the precavernous segment of the left internal carotid artery (ICA). This lesion was considered to be the cause of her symptoms. In addition, the left PCA arose from the basilar artery and the left ICA. There was a small connecting artery between these two PCAs at their proximal segments. These two PCAs fused distally and formed a single PCA. Partial maximum intensity projection (MIP) images showed that the left anterior choroidal artery (AChA) appeared normal. Thus, we concluded that there was no hyperplastic AChA, and there were double anastomoses between the left PCA and PCoA.
Conclusion
We diagnosed the first case of double anastomosis between the PCA and the PCoA. Careful observation using MRA is important for the detection of rare arterial variations. Partial MIP MRA images are useful for identifying tiny arteries, such as the AChA.
Antibiogram in Cutibacterium Acnes: A Comprehensive Study of Oral and Topical Treatments for Acne in the Indian Population
Authors: Monteiro Rochelle , Anthony beena , Bhat Ramesh 
Published: February 2025

Abstract

Injudicious antibiotic therapy in acne has resulted in significant dissemination of cross-resistant strains of Cutibacterium acnes (C. acnes). Resistance patterns vary in different studies, corresponding to the geographic location, and study methods. Prior studies have shown a high resistance to azithromycin, erythromycin and clindamycin and high sensitivity to macrolide antibiotics. There is a paucity of studies evaluating the efficacy of topical anti-acne agents.Our objective was to isolate C.acnes from acne lesions ,and to evaluate the antibiotic susceptibility of oral and topical antibiotics in acne. As antibiotic sensitivity patterns vary with time and prescribing practices, our study aimed to evaluate these patterns, as there is limited data available on Antimicrobial resistance(AMR) in India. Swabs from acne pustules from 124 patients, aged 12 years and above, were obtained and inoculated into selective media for C. acnes and blood agar for isolation of aerobic organisms, gram staining and species identification of Cutibacterium. The isolated bacteria were cultured and evaluated for antibiotic sensitivity using standard disc diffusion techniques. Statistical analysis was performed on SPSS23 software. In our study, the average age of the patients was 21.34 ± 4.2 years, a majority (63.7%) were females. Cutibacterium was isolated in 74.19% of patients. Among oral antibiotics minocycline was the most sensitive to C. acnes (97%); the highest resistance to C. acnes was seen with erythromycin (84%). Topically, benzoyl peroxide had higher sensitivity (48%), and adapalene (95%) and azelaic acid (83%) showed the least antimicrobial activity against C. acnes.The results prove that sensitivity patterns to oral antibiotics remain similar to previous studies. Topical Clindamycin resistance is lower than previously reported resistance rates. Topical benzoyl peroxide showed lower antimicrobial activity in comparison to prior studies. AMR in acne continues to be a concern. Hence the need to maintain stringent guidelines for antibiotic usage in acne.
Predictors of Time to Recovery from Cataract Surgery among Cataract Patients at Menelik II Comprehensive Specialized Hospital: A Retrospective Follow up Study
Authors: Tsegaw Gininu Wendmeneh , Dea Yilma Chisha , Mengesha Melkamu Merid 
Published: February 2025

Abstract

Background
Cataracts are the leading cause of reversible blindness globally, disproportionately affecting populations in low- and middle-income countries. In Ethiopia, cataracts remain a significant public health concern. Despite the effectiveness of cataract surgery in restoring vision, information on recovery time and its predictors remain limited. The aim of this study was to assess time to recovery and its predictors among patients undergoing cataract.
Methods
A retrospective cohort study was conducted on 459 cataract patients who underwent surgery between January 1 and December 31, 2023. Data were randomly extracted from their medical records between June 1 and August 15, 2024. The Kaplan-Meier method was used to estimate the survival probabilities and compare groups, with significant differences tested using the log-rank test. The Weibull regression with the inverse Gaussian frailty was applied following a goodness-of-fit test to identify predictors of time to recovery. Results are presented as adjusted hazard ratios (AHRs) with 95% confidence intervals (CIs). All statistical tests were declared significant at P-value < 0.05.
Results
we reviewed 459 patient cards, and 368 (80.17%, 95% CI: 76.26–83.58%) had recovered from a cataract surgery over 7,919.28 person-weeks. The overall incidence rate of recovery was at 46.47 per 1,000 persons per week (95% CI: 41.95–51.47). The median recovery time was at 18.14 weeks (IQR: 12.29–24, 95% CI: 17.14–18.86). Age over 60 years (AHR = 0.25, 95% CI: 0.07–0.96), urban residence (AHR = 1.77, 95% CI: 1.15–2.70), preoperative visual acuity (medium: AHR = 1.98, 95% CI: 1.23–3.18; high: AHR = 5.83, 95% CI: 1.72–19.77), comorbidities (ocular: AHR = 0.30, 95% CI: 0.15–0.61; systemic: AHR = 0.41, 95% CI: 0.22–0.75), type of surgery (phacoemulsification: AHR = 1.98, 95% CI: 1.06–3.67; intracapsular cataract extraction: AHR = 0.14, 95% CI: 0.03–0.89), and complications (intraoperative: AHR = 0.29, 95% CI: 0.12–0.71; postoperative: AHR = 0.17, 95% CI: 0.06–0.47), and surgeries performed by an ophthalmologist (AHR = 3.44, 95% CI: 1.80–6.55) were statistically significant predictors of time to recovery from cataract surgery.
Conclusion
The median recovery time was shorter than in previous local studies but longer than in developed countries. Improved preoperative assessment, effective comorbidity management, minimizing complications, prioritizing phacoemulsification surgery, and involving skilled ophthalmologists are crucial for enhancing recovery outcomes. Personalized care approaches are recommended to optimize postoperative recovery.
Re-assessment of Aviation Risk Safety Barriers Using Stochastic and Lexical Uncertainty
Authors: Saputra Hendri , Soehodho Sutanto 
Published: February 2025

Abstract

Results of many investigations and statistical data indicate that aircraft accidents are an iceberg phenomenon for understanding the gap among traffic management, operations, and aviation systems. Although the regulator has established a safety barrier as a defense mechanism against hazards, many accidents and incidents continue to occur. Instead of conducting a comprehensive assessment of an accident/incident prevention system, evaluator conducted a common audit investigation to determine the causal and contributing factors of accident. Current problems of concern in aviation safety management involve a series of constraints, evaluation methods, and complex decision-making processes. Uncertainty in these problems adds complexity. Uncertainty has characteristics such as randomness or vagueness, in nature, both might occur concurrently. Probability is a method of calculating the randomness characteristic of stochastic uncertainty and fuzzy logic is a widely used method of determining a vagueness of lexical uncertainty. The combination of these two methods capable of producing integrated models in both types of uncertainty exists simultaneously. The new safety barrier after recalculation is used by describing it in a related fuzzy set accompanied by its degree of membership. This provides clearer guidance for decision-makers to formulate policies based on the conditions experienced, informed by the history of previous events.
Neurotrophic effect magnolol on MPTP/p induced parkinsons disease by regulation of PI3K-AKT-GSK3β via MAPK/mTOR signalling pathway
Authors: Chen Ruili , Zhang Dongdong , Vijayalakshmi Annamalai , Velu Periyannan , Li Nini 
Published: February 2025

Abstract

Introduction
Parkinson's disease (PD) dopaminergic loss may be slowed down by neurotrophic factors (NTFs) activating at a higher level by regulating several signalling pathways, including PI3K, AKT, and Ras-MAPK. Therefore, the goal of the current investigation is to ascertain how neurotrophic magnolol (ML) is about the neurotoxicity of MPTP/p in Parkinson's disease.
Methods
Five weeks of ML treatment markedly reduced the motor impairments, decrease in tyrosine kinase receptor expression (TrKB) and dopamine deficiency and NTFs caused by MPTP/p.
Results
Additionally discovered that ML treatment markedly reduced the activation of MAPK/P38/JNK-related proteins. Additionally, ML therapy enhanced phosphorylation of PI3K, Akt, GSK-3β, and mTOR, indicating ML regulated the PI3K/Akt/mTOR signaling pathway, this reason ML has protected the Brain system. In a chronic parkinson's disease, the current study provides more comprehensive in vivo evidence supporting the neuroprotective action of ML on dopaminergic neurons.
Conclusion
It also raises the idea of employing ML as a novel chemotherapeutic medication.
Analysis of Genetic Diversity Among Wild Soybean (Glycine soja) in Hebei Province, China
Authors: Wu Xintong , Feng Qike , Zhang Zhanying , Zhang Xinyue , Liu Zhi , Yang Qing , Shi Xiaolei , Zhang Mengchen , Yan Long 
Published: February 2025

Abstract

Objectives:
Soybean serves as a crucial source of protein and oil. Wild soybean (Glycine soja) shares genetic similarities with cultivated soybean (Glycine max) but exhibits richer diversity due to lower genetic bottlenecks. The high allelic diversity in wild soybeans provides traits for environmental adaptation, which is useful for cultivated soybeans through breeding. Considering that soybeans originated in northern China and that Hengshui Lake, as a wetland environment, plays a crucial role in preserving species diversity, 17 wild soybean resources at this site were collected and then re-sequenced on the Illumina NovaSeq6000 platform with a depth of 10×.
Data description:
In this study, we collected 17 wild soybean accessions from Hengshui Lake in Hebei Province, China, and performed re-sequencing on the Illumina NovaSeq6000 platform, followed by SNPs identification. Subsequently, we incorporated an additional 62 wild soybean genomic datasets and utilized ADMIXTURE, neighbor-joining tree, and principal component analysis to elucidate population characteristics. The results revealed that these wild soybean accessions could be divided into seven distinct subpopulations.