bluuebunny/crossref_metadata_2025_split huggingface dataset:
Road traffic accidents presenting to the emergency department of a tertiary care hospital in North-East India: A cross-sectional study
Authors: Salam Sushmita , Angami Asho , Devi Thounaojam Meera 
Published: October 2023

Road traffic accidents (RTA) are one of the most common cases brought to a hospital daily. The severity of the situation is not known to most of the masses. It has a high chance of mortality and high disabling capacity due to injuries to the main vital parts of the body.: A cross-sectional study was conducted to analyse the pattern of road traffic accidents as regards the type of victims, offending vehicle, place & time of occurrence, type of injuries sustained, fatality among the RTA victims admitted in the emergency department of a tertiary care hospital in North-East India during January 2021-June 2022.A total of 1002 RTA cases were reviewed, and it was found that most of the RTA (76.3%) were males and 32.7% of the cases belonged to the age group of 21-30 years, followed by the age group of 31-40 years (20.5%). RTAs commonly occurred between 12:01 p.m-6 p.m.; the offending vehicles were 4-wheelers (38%) followed by 2-wheelers (36.4%). Most of the victims were 2-wheeler riders (62.2%) followed by pedestrians (16.8%); the head & face were most affected body parts (42.2%) followed by lower limbs (30.6%) and Imphal West was the most common place of occurrence (48.8%).With the increasing use of motor vehicles, the number of road traffic accidents is rising. It is important to find a pattern of these cases in this part of the country so that we can prevent such unfortunate and unnatural deaths.
Phenomenology of Perception (for Preservation) of Cultural Heritage: Insights on Coastal Kenya
Authors: Stara Flavia 
Published: October 2023

Contemporary social awareness of cultural heritage mostly expresses the understanding of intangible heritage according to rationalist theories of perception. These theories bind modes of recognition to empirical and sensory domains. Yet in order to value and safeguard cultural heritage, be it in the form of ritual practices, symbolic narratives, creation myths or religious and mystical experiences, it is necessary to interpret and appreciate the being and doing of diverse cultural groups. A meaningful analysis of intangible dimensions in cultural heritage needs to consider the role and ontological status of human emotion and imagination.
Individuals are actors in a given space and interact with it as much as they can, depending on the frequency of their visits. Repeated research stays in the Kenyan coastal region offered the author opportunities for communication with a specific natural and cultural environment. This paper explores a participatory process of enhancement and interpretation of intangible cultural heritage that includes feelings and emotions in analysis of the body of knowledge that results from this research approach.
Précocité, efficience et résilience des femelles allaitantes
Authors: MARTIN Pauline , TAUSSAT Sébastien , VINET Aurélie , LAUNAY Frédéric , DOZIAS Dominique , MAUPETIT David , VILLALBA Daniel , FRIGGENS Nicolas , RENAND Gilles 
Published: October 2023

Dans un contexte économique et environnemental où l’élevage est de plus en plus questionné, la précocité, l’efficience alimentaire et la résilience sont devenus des points d’intérêt majeurs de par leur rôle potentiel pour améliorer l’efficience globale des élevages. Pour explorer ces caractères et les liens qui les unissent dans les systèmes allaitants, une expérimentation de grande envergure a été menée entre 2011 et 2021 sur 650 femelles charolaises. Cette expérimentation se découpait en trois périodes que les animaux effectuaient successivement : l’étude de la précocité sexuelle et de développement, l’étude de l’efficience alimentaire au travers de l’ingéré résiduel à deux ans, puis l’étude de la réponse à un challenge alimentaire (composé d’une phase de restriction et d’une phase de récupération) au cours de la lactation. Cet article regroupe l’ensemble des résultats obtenus. Si la précocité sexuelle définie par l’âge à la puberté est fortement liée à l’environnement (conduite, alimentation…) et notamment à la saison de naissance, l’héritabilité du caractère est néanmoins modérée (0,21 ± 0,08). Elle est également corrélée génétiquement avec un petit poids à la naissance et une forte croissance pré-sevrage. L’efficience alimentaire des animaux de deux ans est peu héritable (0,09 ± 0,08) mais corrélée favorablement avec la précocité. Face au challenge alimentaire, les vaches ont des réponses équilibrées entre perte de production laitière et mobilisation de réserves corporelles mais cette réponse moyenne de la race cache des disparités entre individus. Enfin, les génisses les plus efficientes présentaient des productions laitières amoindries une fois en lactation par rapport à leurs homologues inefficientes (jusqu’à − 0,7 kg de lait par jour en milieu de lactation soit environ 10 % de moins), ainsi que des retours en chaleurs plus long dans le cadre de la restriction alimentaire. Ces résultats promeuvent l’importance de considérer l’efficience sur le long terme en prenant en compte ses différentes composantes et de ne pas réaliser une sélection génétique sur une efficience alimentaire mesurée sur un moment court et unique pendant la phase de croissance.
Paramètres génétiques de l’efficience alimentaire et faisabilité d’une sélection en population bovine allaitante
Authors: Taussat Sébastien , Fossaert Clément , Cantalapiedra-Hijar Gonzalo , Griffon Laurent , Martin Pauline , Renand Gilles 
Published: October 2023

La sélection génétique de l’efficience alimentaire est un outil pour améliorer la rentabilité des élevages allaitants. Jusqu’à présent, une évaluation génétique de ce caractère était réalisée en station de contrôle individuel (CI) à partir d’un aliment complet condensé, peu utilisé dans les élevages. L’objectif de cette étude est donc de vérifier si cette sélection est pertinente pour améliorer l’efficience alimentaire dans les élevages, dans un contexte où une même population allaitante doit être à la fois efficiente avec des animaux en croissance alimentés avec des rations fourragères ou des rations concentrées. Pour cela, les populations mâle et femelle du dispositif BEEFALIM 2020 ont été utilisées ainsi que la population de taureaux Charolais passés en stations de CI. Trois critères d’efficience alimentaire ont été utilisés : la consommation moyenne journalière résiduelle (CMJR), le gain moyen quotidien résiduel (GMQR) et le ratio d’efficience alimentaire (EA). Des estimations de paramètres génétiques ont été réalisées pour appréhender les relations génétiques de l’efficience alimentaire entre les populations étudiées. Concernant la voie mâle, une interaction génotype x milieu sur la CMJR existerait, qui pourrait donc entrainer un progrès génétique plus faible concernant la sélection de ce caractère. Il serait donc pertinent de phénotyper à partir de fourrage pour diminuer cette interaction. Concernant les génisses, la précision des estimations est limitée en raison du faible nombre de génisses phénotypées et du fait que celles-ci étaient phénotypées à l’âge de deux ans et avaient donc des croissances moindres et moins comparables aux mâles phénotypés plus jeunes.
IMPLEMENTASI BLOC PATTERN PADA PENGEMBANGAN FRONTEND FITUR TOP UP LINKAJA APLIKASI M-BANKING AGEN46 DENGAN	TEKNOLOGI FLUTTER (STUDI KASUS : PT. BANK NEGARA INDONESIA TBK)
Authors: Anastasia Farah Dila , Paputungan Irving Vitra 
Published: October 2023

Abstract–Proses pengembangan aplikasi mobile atau aplikasi seluler untuk perusahaan bisnis global menjadi sangat penting di era digital saat ini. Penting bagi sebuah perusahaan untuk memanfaatkan dan memilih teknologi yang digunakan dalam efisiensi pengembangan sistem. PT. Bank Negara Indonesia (BNI) memilih Flutter sebagai framework dalam mengembangkan proyek Agen46. Hal ini dalam rangka mendukung proses transmigrasi mobile banking (m-banking) Agen46 dari Android menuju aplikasi berbasis multiplatform. Pengembangan yang dilakukan menggunakan bahasa pemrograman Dart. Penggunaan mobile banking memberikan kemudahan bagi masyarakat dalam melakukan kegiatan transaksi. Dengan dukungan teknologi yang semakin maju memberi dampak terhadap munculnya inovasi baru dalam dunia perbankan salah satunya adalah adanya produk uang elektronik (e-money). PT Bank Negara Indonesia menyediakan fasilitas pembayaran nontunai dalam bentuk uang elektronik (e-money). Hal ini merupakan produk inovasi sejak adanya metode top up dalam sistem pembayaran. Flutter dijadikan solusi sebagai framework yang akan digunakan dalam pengembangan proyek aplikasi m-banking Agen46 karena dapat membuat aplikasi mobile Android maupun iOS hanya dengan satu basis coding (codebase) dalam sekali waktu. Metode yang digunakan untuk membuat aplikasi m-banking tersebut adalah Agile Scrum. Pembahasan dan Hasil yang didapatkan yaitu alur pengembangan frontend aplikasi m-banking dengan implementasi BLoC Pattern, hasil pembuatan fitur top up e-money dengan menggunakan Flutter, hasil struktur folder pengembangan fitur dengan BLoC Pattern, hasil pengujian fitur dengan menggunakan BlackBox testing secara manual. Setelah dilakukan pengembagan hingga pada tahap pengujian dengan menggunakan BlackBox testing menunjukan bahwa implementasi BLoC Pattern pada teknologi Flutter dinilai mampu memudahkan developer dalam mengembangkan fitur top up e-money dalam aplikasi perbankan ke dalam aplikasi berbasis multiplatform.
The Emerging Role of Tertiary Lymphoid Structures in Breast Cancer: A Narrative Review
Authors: Narvaez Dana , Nadal Jorge , Nervo Adrian , Costanzo Maria Victoria , Paletta Claudio , Petracci Fernando E. , Rivero Sergio , Ostinelli Alexis , Freile Berenice , Enrico Diego , Pombo Maria Teresa , Amat Mora , Aguirre Alvarez Edgar Danilo , Chacon Matias , Waisberg Federico 
Published: October 2023

This narrative review aims to clarify the role of tertiary lymphoid structures in breast cancer. We examine their development, composition, prognostic value and current ways of recognising them. A comprehensive literature review was performed using PubMed/Medline, Scopus and EMBASE databases. A significant area of interest in breast cancer research involves targeting immune checkpoint molecules, particularly in the triple-negative subtype, where treatment options remain limited. However, existing biomarkers have limitations in accurately predicting treatment response. In this context, tertiary lymphoid structures (TLS) emerge as a prognostic biomarker and also as a promising predictive marker for response. TLS are ectopic lymphoid formations or neo-organogenesis that can develop after prolonged exposure to inflammatory signals mediated by chemokines and cytokines. Their presence is inversely correlated with estrogen receptor (ER) and/or progesterone receptor (PR) expression, but positively associated with a higher pathologic complete response rate and improved overall survival. In certain scenarios, TLS-positive tumors were associated with improved outcomes regardless of the presence of PDL-1 (programmed cell death ligand 1) expression or and TILs (tumor-infiltrating lymphocytes).
Effects of Dipping and Folded Structure on Gas Production from Hydrate-Bearing Sediments
Authors: Li Yaobin , Xu Tianfu , Xin Xin , Zang Yingqi , Yu Han , Zhu Huixing , Yuan Yilong 
Published: October 2023

Summary
Due to a dipping and folded structure, hydrate-bearing sediments (HBS) have obvious fluctuation characteristics, and the internal temperature and pressure of HBS are unevenly distributed. Subsequently, gas and water production of natural gas hydrate (NGH) is affected. When using a numerical simulation method to predict effectively the productivity of HBS, it is necessary to establish a conceptual model that considers the formation fluctuation. However, few reported studies accurately describe the fluctuation characteristics of HBS in numerical simulation models. Therefore, the spatial evolution of gas production, water production, and seepage parameters of each model was compared by establishing the initial temperature and pressure model of each representative model pair, using the TOUGH + HYDRATE (T + H) code for a long-time simulation; the production process of gas and water and spatial evolution of seepage parameters of each model were compared; and then the spatial evolution of gas production, water production, and seepage parameters of the different dipping/folded HBS was obtained. The spatial evolution of water production and seepage parameters for different dipping/folded HBS is obtained. (a) The dipping and folded structure had an obvious influence on the spatial distribution of the initial temperature and pressure of HBS. (b) The limits of heat supply and seepage capacity of the fluctuating HBS gave lower gas production than in horizontal HBS. There should be more emphasis on heat supply conditions and the formation of secondary hydrates. (c) The additional pore water in fluctuating HBS is not conducive to the discharge of methane. Consequently, the development of improved water blocking measures is significant for the future large-scale production of NGH.
The establishment of human embryonic stem cell lines demonstrated that chimeric embryos can self-correct
Authors: Li Chuyu , Dong Xiaohan , Xie Jiazi , Dong Juan , Gao Chao , Xia Meng , Lin Yuting , Cui Yugui , Qin Lianju , Wu Wei 
Published: October 2023

Abstract
Background：Low-level mosaicism is a common trait of early human development. Although mosaic embryos may lead to healthy live births, the direct effects of mosaicism are unknown. While embryo self-correction was demonstrated in mouse models, humans can only study the effects of chromosomal aberrations and blastocyst mosaicism on the early peri-implantation period by extended in vitro embryo culture up to 12 days post-fertilization.
Methods：The established culture protocols were followed to generate embryonic stem cells. The 24 high-quality mosaicism / aneuploid mosaicism blastocysts were detected by PGT-A. The isolated ICMs were seeded onto feeder-free dishes, and after 10-12 days of culture, there were six blastocyst ICM-generated stem cell clones. Cells shed during stem cell growth were harvested, and next-generation sequencing was performed on stem cells and the shed. To test pluripotency, a small number of stem cells were isolated and subcultured.
Results：The PGD status was confirmed from the results ofnext-generation sequencing of stem cell exfoliated cells and stem cells, the chimeras in five blastocysts were fully repaired while the chimera in one blastocyst was partially repaired. Simultaneously the cells were verified to have pluripotency and the ability to differentiate into three germ layers by immunofluorescence, flow cytometry, and in vitro differentiation analyses.
Conclusions：Human mosaicism/aneuploid mosaicism blastocysts can self-correction by eliminating chimeric cells.
The Effect of Knowledge Brokering on Cardiac Nurses' Empathy with Their Patients: A Field Randomized Controlled Trial
Authors: Galehdarifard Atefeh , Khademi Mojgan , Gholami Mohammad , Radfar Moloud , Ebrahimzadeh Farzad , Imani-Nasab Mohammad-Hasan 
Published: October 2023

Abstract

Background
Previous reports have suggested a relationship between empathetic behaviors and a reduction in cardiovascular events. However, evidence has also revealed a lack of empathy among nurses. Therefore, interventions are necessary to improve empathy among cardiac nurses.
Purpose
The objective of this study was to determine the effect of knowledge brokering on the empathy of cardiac nurses with their patients.
Methods
This field randomized controlled trial involved a total of 100 cardiac nurses who were divided into two groups: control and intervention. Participants were assigned to these groups using stratified random allocation. In the intervention group, knowledge brokering was conducted using Dobbin's seven-stage method. Data was collected using the Empathy Construct Rating Scale (ECRS), which provides an overall score ranging from +252 (well-developed empathy) to -252 (lack of empathy). The collected data was then analyzed using SPSS version 21, with a significance level set at < .05. The independent-samples t-test was used to compare mean empathy scores before the intervention, while the paired-samples t-test and the generalized linear model with an identity link function were utilized for within- and between-group comparisons after the intervention, respectively.
Results
The mean empathy change score (MECS) ± standard deviation was 22.90 ± 50.93 in the intervention group (p = .003) and 7.10 ± 60.20 in the control group (p = .408). The MECS between the study groups was compared based on the baseline empathy score (BES) (<100, ≥100). This comparison revealed that in nurses with BES ≥100, the adjusted MECS in the intervention group was significantly higher than the control group (11.44 units versus -15.42 units). Conversely, in nurses with BES <100, the adjusted MECS in the intervention group was lower than the control group (52.36 units versus 65.00 units).
Conclusions
The findings of this study indicate that the effectiveness of knowledge brokering in translating empathy knowledge depends on the BES of nurses. The utilization of this intervention can enhance empathetic behaviors in cardiac nurses with a BES ≥100. This empirical study contributes to a better understanding of knowledge brokering as a novel intervention.
Modeling and statistical study of a DBN for Cloud and Cloudlet environment within IoT technologies
Authors: KORTAS Nawel 
Published: October 2023

Abstract
Cloud Computing plays a major role in this, in particular by making all connected devices work together. Virtual machine (VM) migration concept and the architecture of datacenters for cloud computing have a significant impact on latency and energy cost. In order to lower latency and energy usage while maintaining SLA restrictions, this work focuses on how to employ VM migration to achieve steady physical machine use. Using the novel MVMM scheduler method for virtual machine migration, we suggest modeling and statistical analysis of a Dynamic Bayesian Network for cloud and cloudlet environments within IoT technologies. It use a Dynamic Bayesian Network study to decide where and when a particular VM migrates. Indeed, to improve latency and energy consumption by limiting the number of upcoming migrations, the statistical study computes a score for each VM candidate for migration using datacenter metrics as input..
EGFRvIII overexpression causes loss of neural stem cells phenotype
Authors: Włodarczyk Aneta , Tręda Cezary , Grot Dagmara , Stoczyńska-Fidelus Ewelina , Rieske Piotr 
Published: October 2023

Abstract
It is now accepted that the formation of EGFRvIII, a mutated variant of EGFR, may occur early in the tumorigenesis of glioblastoma. Furthermore, it is speculated that glioblastoma may originate from neural stem cells (NSCs), and EGFRvIII itself is considered a marker of cancer stem cells. Therefore, we decided to test the hypothesis that EGFRvIII alteration can occur as the first one in NSC. We created a model of iNSc showing constitutive and induced expression of EGFRvIII. After a series of analyses, we found that EGFRvIII contributed to the loss of SOX2 and nestin - markers of NSCs in both tested models. Interestingly, however, with constitutive expression of EGFRvIII, a senescence phenomenon was observed, while expression induced by low concentrations of doxycycline increased the rate of cell proliferation. Moreover, we observed senescence in the case of high constitutive EGFRvIII expression. Thus, the results suggest that NSCs may not be the origin of glioblastoma cells, and the other cells simultaneously expressing GFAP and SOX2 should be considered the origin of glioblastoma.
Ketogenic Diet Improves Motor Function and Motor Unit Connectivity in Aged C57BL/6 Mice
Authors: Padilla Carlos J , Harris Hallie , Volek Jeff S , Clark Brian C , Arnold W. David 
Published: October 2023

Abstract
Objective
Pathological, age-related loss of muscle function, commonly referred to as sarcopenia, contributes to loss of mobility, impaired independence, as well as increased risk of adverse health events. Sarcopenia has been attributed to changes in both neural and muscular integrity during aging. Current treatment options are primarily limited to exercise and dietary protein fortification, but the therapeutic impact of these approaches are often inadequate. Prior work has suggested that a ketogenic diet (KD) might improve healthspan and lifespan in aging mice. Thus, we sought to investigate the effects of a KD on neuromuscular indices of sarcopenia in aged C57BL/6 mice.
Design:
A randomized, controlled pre-clinical experiment consisting of longitudinal assessments performed starting at 22-months of age (baseline) as well as 2, 6 and 10 weeks after the start of a KD vs. regular chow intervention.
Setting:
Preclinical laboratory study.
Sample size:
Thirty-six 22-month-old mice were randomized into 2 dietary groups: KD [n = 22 (13 female and 9 male)], and regular chow [n = 15 (7 female and 8 male)].
Measurements:
Measures included body mass, hindlimb and all limb grip strength, rotarod for motor performance, plantarflexion muscle contractility, motor unit number estimations (MUNE), and repetitive nerve stimulation (RNS) as an index of neuromuscular junction transmission efficacy recorded from the gastrocnemius muscle. At end point, blood samples were collected to assess blood beta-hydroxybutyrate levels.
Statistical Analysis:
Two-way ANOVA mixed-effects analysis (time x diet) were performed to analyze grip, rotarod, MUNE, and muscle contractility data.
Results
Beta-hydroxybutyrate (BHB) was significantly higher at 10 weeks in mice on a KD vs control group (0.83 ± 0.44 mmol/l versus 0.42 ± 0.21 mmol/l, η2 = 0.265, unpaired t-test, p = 0.0060). Mice on the KD intervention demonstrated significantly increased hindlimb grip strength (time x diet, p = 0.0030), all limb grip strength (time x diet, p = 0.0523), and rotarod latency to fall (time x diet, p = 0.0021). Mice treated with the KD intervention also demonstrated significantly greater MUNE (time x diet, p = 0.0064), but no difference in muscle contractility (time x diet, p = 0.5836) or RNS (time x diet, p = 0.9871).
Conclusion
KD intervention improved neuromuscular and motor function in aged mice. This pre-clinical work suggests that further research is needed to assess the efficacy and physiological effects of a KD on indices of sarcopenia.