bluuebunny/crossref_metadata_2025_split huggingface dataset:
KMT2A oncoproteins induce epigenetic resistance to targeted therapies
Authors: Janssens Derek H. , Duran Melodie , Otto Dominik J. , Wu Weifang , Xu Yiling , Kirkey Danielle , Mullighan Charles G. , Yi Joanna S. , Meshinchi Soheil , Sarthy Jay F. , Ahmad Kami , Henikoff Steven 
Published: December 2023

AbstractChromosomal translocations involving theLysine-Methyl-Transferase-2A(KMT2A) locus generate potent oncogenic fusion proteins (oncoproteins) that disrupt regulation of developmental gene expression. By profiling the oncoprotein-target sites of 36 broadly representativeKMT2A-rearranged leukemia samples, including three samples that underwent a lymphoid-to-myeloid lineage-switching event in response to therapy, we find the genomic enrichment of the oncoprotein is highly variable between samples and subject to dynamic regulation. At high levels of expression, the oncoproteins preferentially activate either an acute lymphoblastic leukemia (ALL) program, enriched for pro-B-cell genes, or an acute myeloid leukemia (AML) program, enriched for hematopoietic-stem-cell genes. The fusion-partner-specific-binding patterns over these gene sets are highly correlated with the prevalence of each mutation in ALL versus AML. In lineage-switching samples the oncoprotein levels are reduced and the oncoproteins preferentially activate granulocyte-monocyte progenitor (GMP) genes. In a sample that lineage switched during treatment with the menin inhibitor revumenib, the oncoprotein and menin are reduced to undetectable levels, but ENL, a transcriptional cofactor of the oncoprotein, persists on numerous oncoprotein-target loci, including genes in the GMP-like lineage-switching program. We propose KMT2A oncoproteins promote lineage-switching events through dynamic chromatin binding and can induce epigenetic lesions, marked by ENL, that support resistance to targeted therapies.
Age-associated aberrations of cumulus-oocyte interaction and microfilamentous structure in the zona pellucida decline female fertility
Authors: Ishikawa-Yamauchi Yu , Emori Chihiro , Mori Hideto , Endo Tsutomu , Kobayashi Kiyonori , Watanabe Yuji , Sagara Hiroshi , Nagata Takeshi , Motooka Daisuke , Ninomiya Akinori , Ozawa Manabu , Ikawa Masahito 
Published: December 2023

AbstractOne of the major age-related declines in female reproductive function is the reduced quantity and quality of oocytes. Here we demonstrate that structural changes in the zona pellucida (ZP) decrease fertilization rates from 34- to 38-week-old female mice, equivalent to the mid-reproductive of human females. In middle-age ovaries, the decline in the number of transzonal projections was accompanied by a decrease in cumulus cell-oocyte interactions, resulting in a deterioration of the oocyte quality. Scanning electron microscopy showed the ZP surface microfilament structure transitioning from rugged to smooth with age, leading to decreased fertilization rates due to impaired sperm binding to the ZP. Moreover, the fertilization rate of middle-age mice was restored to a comparable level to that of young mice by destabilizing the ZP in the presence of glutathione. These results suggest that the age-related structural changes in the ZP is a key for successful fertilization at reproductive age.
Decoding mTOR signalling heterogeneity in the tumour microenvironment using multiplexed imaging and graph convolutional networks
Authors: Zuhair Razan , Eastwood Mark , Jones Megan , Cross Amy , Hester Joanna , Issa Fadi , Ginty Fiona , Sailem Heba 
Published: December 2023

AbstractEvaluating the contribution of the tumour microenvironment (TME) in tumour progression has proven a complex challenge due to the intricate interactions within the TME. Multiplexed imaging is an emerging technology that allows concurrent assessment of multiple of these components simultaneously. Here we utilise a highly multiplexed dataset of 61 markers across 746 colorectal tumours to investigate how complex mTOR signalling in different tissue compartments influences patient prognosis. We found that the signalling of mTOR pathway can have heterogeneous activation patterns in tumour and immune compartments which correlate with patient prognosis. Using graph neural networks, we determined the most predictive features of mTOR activity in immune cells and identified relevant cellular subpopulations. We validated our observations using spatial transcriptomics data analysis in an independent patient cohort. Our work provides a framework for studying complex cell signalling and reveals important insights for developing mTOR-based therapies.
The professional competence of faculty members from the students’ perspective at Kuwait University and Palestine Technical University Kadoorie
Authors: Obied Asem , Alajmi Abdullah 
Published: December 2023

PurposeThe study aimed at identifying the degree of professional competence of faculty members from the students’ perspective at Kuwait and Palestine Technical University Kadoorie, and identifying the effect of the variables of gender and academic year.Design/methodology/approachThe researchers developed a 24-item questionnaire and administered it to 115 students each from Kuwait (male: 57, female: 58) and Palestine Technical University Kadoorie (male: 21, female: 94). The study used a descriptive approach to analyze the collected data.FindingsAccording to the students' perspective, the average professional competence of faculty members at Kuwait University is 2.74 for the teaching competencies, 2.29 for the technology competencies, 2.65 for the evaluation competencies and 2.71 for the human competencies. Similarly, at Palestine Technical University Kadoorie, the mean of the professional competencies of faculty members from the students' perspective is 2.31 for the teaching competencies, 1.96 for the technology competencies, 2.24 for the evaluation competencies and 2.34 for the human competencies. There were significant differences in the degree of professional competence at Kuwait and Palestine Technical University Kadoorie due to the gender of all domains in favor of females. There were significant differences in the degree of professional competence in Kuwait due to the academic year of the technology domain between the first year and second year, in favor of the second year. There were significant differences due to the variable of the academic year of the human domain between the first year and the third year, in favor of the third year. There were significant differences in the degree of professional competence at Palestine Technical University Kadoorie due to the academic year of the technology domain (second, third, fourth year and more) and second year, in favor of (the second year). There were significant differences due to the academic year of the human domain between the first and second year, in favor of second year.Originality/valueThe authors hope that their findings will inspire further research in this area and help universities to better support their faculty members and improve student outcomes.
Multi-view fuzzy C-means clustering with kernel metric and local information for color image segmentation
Authors: Cai Xiumei , Yang Xi , Wu Chengmao 
Published: December 2023

PurposeMulti-view fuzzy clustering algorithms are not widely used in image segmentation, and many of these algorithms are lacking in robustness. The purpose of this paper is to investigate a new algorithm that can segment the image better and retain as much detailed information about the image as possible when segmenting noisy images.Design/methodology/approachThe authors present a novel multi-view fuzzy c-means (FCM) clustering algorithm that includes an automatic view-weight learning mechanism. Firstly, this algorithm introduces a view-weight factor that can automatically adjust the weight of different views, thereby allowing each view to obtain the best possible weight. Secondly, the algorithm incorporates a weighted fuzzy factor, which serves to obtain local spatial information and local grayscale information to preserve image details as much as possible. Finally, in order to weaken the effects of noise and outliers in image segmentation, this algorithm employs the kernel distance measure instead of the Euclidean distance.FindingsThe authors added different kinds of noise to images and conducted a large number of experimental tests. The results show that the proposed algorithm performs better and is more accurate than previous multi-view fuzzy clustering algorithms in solving the problem of noisy image segmentation.Originality/valueMost of the existing multi-view clustering algorithms are for multi-view datasets, and the multi-view fuzzy clustering algorithms are unable to eliminate noise points and outliers when dealing with noisy images. The algorithm proposed in this paper has stronger noise immunity and can better preserve the details of the original image.
The struggle of sensor-based digital servitization: analysis and perspectives for organizational digital transformation in SMEs
Authors: Trabert Thomas , Doerr Luca , Lehmann Claudia 
Published: December 2023

PurposeThe organizational digital transformation (ODT) in companies presents small and medium-sized enterprises (SMEs) – who remain at the beginning of this transformation – with the challenge of offering digital services based on sensor technologies. Against this backdrop, the present paper identifies ways SMEs can enable digital servitization through sensor technology and defines the possible scope of the organizational transformation process.Design/methodology/approachAround 21 semi-structured interviews were conducted with experts from different hierarchical levels across the German manufacturing SME ecosystem. Using the Gioia methodology, fields of action were identified by focusing on influencing factors and opportunities for developing these digital services to offer them successfully in the future.FindingsThe complexity of existing sensor offerings must be mastered, and employees' (data) understanding of the technology has increased. Knowledge gaps, which mainly relate to technical and organizational capabilities, must be overcome. The potential of sensor technology was considered on an individual, technical and organizational level. To enable the successful implementation of service offerings based on sensor technology, all relevant stakeholders in the ecosystem must network to facilitate shared value creation. This requires standardized technical and procedural adaptations and is an essential prerequisite for data mining.Originality/valueBased on this study, current problem areas were analyzed, and potentials that create opportunities for offering digital sensor services to manufacturing SMEs were identified. The identified influencing factors form a conceptual framework that supports SMEs' future development of such services in a structured manner.
Supply chain resilience as a system quality: survey-based evidence from multiple industries
Authors: Gruchmann Tim , Stadtfeld Gernot M. , Thürer Matthias , Ivanov Dmitry 
Published: December 2023

PurposeExperiencing more frequent, system-wide disruptions, such as pandemics and geopolitical conflicts, supply chains can be largely destabilized by a lack of materials, services or components. Supply chain resilience (SCRES) constitutes the network ability to recover after and survive during such unexpected events. To enhance the understanding of SCRES as a system-wide quality, this study tests a comprehensive SCRES model with data from multiple industries.Design/methodology/approachThe study proposes a theoretical framework conceptualizing SCRES as system quality, extending the classical proactive/reactive taxonomy by multiple system states consisting of the supply system properties, behaviors and responses to disruptions. Underlying hypotheses were tested using an online survey. The sample consists of 219 responses from German industries. Maximum likelihood structural equation modeling (ML-SEM) and moderation analysis were used for analyzing the survey data. The study was particularly designed to elaborate on supply chain theory.FindingsTwo pathways of parallel SCRES building were identified: proactive preparedness via anticipation and reactive responsiveness via agility. Both system responses are primarily built simultaneously rather than successively. The present study further provides empirical evidence on the central role of visibility and velocity in achieving comprehensive SCRES, while flexibility only exerts short-term support after a disruption. The study additionally points to potential “spillover effects” such as the vital role of proactive SCRES in achieving reactive responsiveness.Originality/valueThe present study confirms and expands existing theories on SCRES. While stressing the multidimensionality of SCRES, it theorizes the (inter-)temporal evolution of a system and offers practical guidelines for SCRES building in various industrial contexts. It thus supports the transformation toward more resilient and viable supply chains, contributing to the increasing efforts of middle-range theory building to achieve an overarching theory. The study also points to potential future research avenues.
Subjective assessment of women's economic welfare in public sector organizations of Mardan, Northern Pakistan
Authors: Begum Nazia , Tariq Muhammad , Jehan Noor , Khan Farah 
Published: December 2023

PurposeThe measurement of women's economic welfare and exploring its underlying factors have been undervalued in the context of Khyber Pakhtunkhwa, Pakistan. This study addressed this gap by focusing on assessing women's subjective economic welfare and its socioeconomic and cultural determinants in the education and health sectors within Mardan, Northern Pakistan.Design/methodology/approachThe study used stratified random sampling techniques for the selection of sample respondents and collected data through a well-structured questionnaire. To measure women’s economic welfare, the study utilizes Lorenz curves, the Gini index, the Sen Social Welfare function and an individual's gross monthly income. Furthermore, the ordinary least squares method was utilized to analyze the determinants of economic welfare.FindingsThe findings show greater income inequality and a lower welfare level for women in the education sector compared to the health sector. Likewise, the study identifies several key determinants, such as age, educational qualification, job experience, respect for working women, outside and work-place problems and the suffering of family members of working women for their economic well-being.Originality/valueThis study makes valuable contributions to the literature by focusing on the cultural perspective of Pakhtun women in Mardan and providing a context-specific understanding of subjective economic welfare. Additionally, the authors collected first-hand data, which gave an original outlook on working women's current economic welfare level. Furthermore, this study undertakes a comparative analysis of working women's welfare in the health and education sectors. This comparison offers a more accurate portrayal of the challenges and opportunities specific to these occupations.Peer reviewThe peer-review history for this article is available at: https://publons.com/publon/10.1108/IJSE-04-2023-0246
Toward sustainable governance with participatory budgeting
Authors: Sinervo Lotta-Maria , Bartocci Luca , Lehtonen Pauliina , Ebdon Carol 
Published: December 2023

PurposeSustainability is a pressing challenge of governance and public financial management. One key element of sustainable governance is the role of citizens. Participatory budgeting (PB) is a participatory tool with which citizens can influence public administration. PB is a democratic process that grants people real power over real money and it has spread around the world. This special issue explores the role of PB in the context of sustainable governance. In this editorial, the authors aim to approach PB as a form of sustainable governance.Design/methodology/approachIn this editorial, the authors collaborate in the analysis of how PB is implicated in the public management of complex social, economic and ecological issues. The authors identify key dimensions of internal and external sustainability based on prior research. The authors approach these dimensions as an internal–external nexus of sustainable governance in which organizational and financial sustainability are the internal dimensions and socio-political and environmental sustainability are the external dimensions.FindingsEven though PB can be seen as one tool for citizen participation, it has the potential to foster sustainability in multiple ways. PB, as a form of sustainable governance, requires a financially and administratively sustainable organizational process that results in the institutionalization of PB. It also includes thorough consideration of socio-political and environmental sustainability impacts of PB.Originality/valueAcademics are actively studying PB from various perspectives. However, most of this work has approached PB from the viewpoints of design and results of PB, and less is known about its institutional settings. PB has not yet been adequately studied in the context of sustainability, and there is a need to scrutinize PB as a form of sustainable governance.
Identifying critical challenges and government’s responses for Filipino seafarers during the COVID-19 pandemic
Authors: Lin Moses Shang-Min , Sarza Noel A. 
Published: December 2023

PurposeThe COVID-19 pandemic had a disastrous impact on a substantial number of Filipino seafarers. The government agencies played a crucial role in helping the seafarers. This paper aims to explore the challenges that the Filipino seafarers faced amid the pandemic and initially evaluate the Philippine government’s countermeasures.Design/methodology/approachThis paper reviewed academic literature and secondary data to identify and analyze the impact of the COVID-19 pandemic on seafarers. To identify the full range of policies and measures that have been adopted by the Philippines’ government amid the pandemic to mitigate the impact on seafarers, an extensive survey of various sources was conducted. Furthermore, an analytic hierarchy process (AHP) survey was conducted from seafarers' perspective to analyze the priority of these government initiatives.FindingsThis study identifies four key challenges for seafarers during the pandemic: crew change crisis, healthcare shortages, certification and the derived problems including financial and mental health issues. Notably, mental health problems are prevalent but receive limited government attention. Despite the government’s efforts to assist seafarers, the AHP survey identifies crew change assistance as the most crucial issue, possibly impacting all others.Originality/valueThis paper recognizes the significant information regarding aid in recovery management and provides much-needed assistance to seafarers during the pandemic and similar crisis situations. It bridges the research gaps and contributes knowledge to the government, stakeholders and various entities such as shipping companies, ship management firms and seafarers' manning agencies.
Firm innovation: technological boundary-spanning search and knowledge base and distance
Authors: Zhu Xianglin , Yang Naiding , Zhang Mingzhen , Wang Yu 
Published: December 2023

PurposeTechnical knowledge is a key factor in firm innovation. This study aims to construct a theoretical framework of technological boundary-spanning search, exploratory innovation and exploitative innovation to help firms adjust their search strategies and improve the effect of external resources on internal innovation.Design/methodology/approachThe study uses questionnaires to collect data and conducts empirical analysis using SPSS25 and AMOS24.FindingsTechnological boundary-spanning search is positively correlated with ambidextrous innovation. Additionally, knowledge base positively moderates the effect of technological boundary-spanning search on ambidextrous innovation and knowledge distance negatively moderates the effect of technological boundary-spanning search on ambidextrous innovation. When a firm’s knowledge base is robust, its ambidextrous innovation can benefit more from technological boundary-spanning search. Additionally, when the knowledge distance is less, a firm’s ambidextrous innovation can benefit more from technological boundary-spanning search.Originality/valueConsidering organizational ambidexterity, this study divides firm innovation into exploratory innovation and exploitative innovation and presents a theoretical framework for the effect of technological boundary-spanning search on ambidextrous innovation. Additionally, it provides a comprehensive understanding of the crucial roles of knowledge base and knowledge distance in the relationship between technological boundary-spanning search and exploratory and exploitative innovation.
Hubris research in business: taking stock and moving forward
Authors: Picone Pasquale Massimo , Galvagno Marco , Pisano Vincenzo 
Published: December 2023

PurposeThere is growing interest in how hubris bias shapes managerial and entrepreneurial judgments and decisions and, in turn, firm strategy and performance. Based on a 44-years dataset of articles reaching the beginning of 2023, the authors offer a synthesis of hubris research published within business journals.Design/methodology/approachThe authors implement a mixed-method approach offering a content representation of 600 peer-reviewed articles extracted from Scopus. The authors conduct a bibliometric investigation – employing Excel, VOSViewer and Biblioshiny software – and perform a qualitative review.FindingsThe analysis unveils four thematic clusters: hubris bias in financial policies (Cluster 1), hubris bias in restructuring deals (Cluster 2), hubris bias in entrepreneurial contexts (Cluster 3) and hubris bias in strategic decision-making (Cluster 4). Moreover, the authors infer that hubris research in business predominantly developed from three disciplinary perspectives – finance, entrepreneurship and strategic management – and progressed with limited interdisciplinary dialogue.Practical implicationsThe authors call practitioners' attention to the impact of the hubris bias in forming financial, entrepreneurial and strategic choices. Managers get conscious of the risks of hubristic choices; hence, they implement organizational practices that move forward with unbiased (or less biased) judgments and decisions.Originality/valueThe authors offer an up-to-date and comprehensive view of hubris research in business. Furthermore, the authors provide an integrative framework and a research agenda.