bluuebunny/crossref_metadata_2025_split huggingface dataset:
The SEDIMENTOLOGICAL ANALYSIS, DEPOSITIONAL ENVIRONMENT AND SEQUENCE STRATIGRAPHIC STUDY OF IDA 4, 5, 6 WELLS NIGER DELTA BASIN, NIGERIA
Authors: Chukwuma-Orji Jacinta Nkiru 
Published: November 2023

Sequence stratigraphic study divides sedimentary successions into unconformity or maximum flooding surface bounded units (sequence) that form during a single, major cycle of sea-level change. Detailed sedimentological and sequence stratigraphic studies of the strata penetrated by Ida-4, 5, and 6 wells were carried out to deduce the depositional environment and correlate the stratigraphic units. The wells are located in the coastal swamp depobelt of the Eastern Niger Delta. Studied samples were dry-sieved for sedimentological analyses. Each fraction was studied under reflected light microscope. The lithology consists of an alternation of shale and sandstone units. The grain size of the sandstone units consists of fine to medium grains, occasionally coarse to granule-sized grains. Dominant accessories minerals are ferruginous materials, shell fragments, carbonaceous detritus, and few records, of mica flakes, glauconite, and pyrite. Regular sand and shale intercalation pattern on the Gamma Ray log permitted easy recognition of sub-cycles (autocycles) of sedimentation in an extensively developed paralic sequence. Paleoenvironmental reconstruction using accessories minerals recognizes shallow water settings with intermittent deeper water conditions. Rapid sedimentation rates are inferred in the studied area based on the observed alternation of thick sandstone, shale, and mudstone units. The MFS and SB were dated 9.5 Ma and 10.35 Ma respectively. Lithologic and system tracts correlations show lateral continuity of sandstone units (potential reservoirs) depicted in the lithofacies subcycles correlation. This is useful in the determination of reservoir geometry, areal coverage, and calculation of the volume of accumulated hydrocarbon, and directing well trajectory during the drilling operation.
Māori cultural values and soil fertility management – an exploratory study
Authors: Lucock Xiaomeng , Moir Jim , Ruwhiu Diane 
Published: November 2023

Collectively owned Māori farming entities work much of the remaining Māori freehold land in Aotearoa New Zealand (~5% of total) and the majority of these are registered in the Māori Land Court. The effective and sustainable management of these farms is vital tolandowners (e.g., whānau/hapū/iwi) whose prosperity is dependent on the wealth and strength of connection generated from this land (whenua), which is also a source of wellbeing. There are some distinct features of the institutional factors of Māori farms that impact on how they are managed. For example, because Māori land can never be sold (Te Ture Whenua Māori Act 1993), realising capital gain is not an option for Māori farmers. Māori farm managers hence focus on cashflow and profit within the farming operations, which can sometimes put pressure on important yet discretionary investment expenditures, such as fertiliser costs (Cottrell 2016). However, as nutrients are taken off farms through animal products, soil fertility management is fundamental to the replenishing of nutrients on farms to maintain productivity and profitability (Haynes and Williams 1993). Consequently, fertiliser costs take up a significant proportion of farm expenditure for most New ealand farms, impacting on their profitability (Hedley 2015). The retention and control of Māori land remains a top priority for Māori land managers, with whom the continuous provision of return through productivity or profitability is seen as essential for landowners (e.g., whānau), and the long-term sustainable managementand delivery of services is largely driven by cultural values. So, where does the balance lie between ongoing provision and potentially discretionary expenditure? The present research set out to explore the nuances behind such a question.
Effects of kidney perfusion on renal stiffness and tissue fluidity measured with tomoelastography in an MRI-compatible ex vivo model
Authors: Castelein Johannes , Pamplona Carolina , Armstrong Junior Roberto , Vidal dos Santos Marina , Sack Ingolf , Dierckx Rudi , Moers Cyril , Borra Ronald 
Published: November 2023

Stiffness plays a vital role in diagnosing renal fibrosis. However, perfusion influences renal stiffness in various chronic kidney diseases. Therefore, we aimed to characterize the effect of tissue perfusion on renal stiffness and tissue fluidity measured by tomoelastography based on multifrequency magnetic resonance elastography in an ex vivo model. Five porcine kidneys were perfused ex vivo in an MRI-compatible normothermic machine perfusion setup with adjusted blood pressure in the 50/10–160/120 mmHg range. Simultaneously, renal cortical and medullary stiffness and fluidity were obtained by tomoelastography. For the cortex, a statistically significant (p &lt; 0.001) strong positive correlation was observed between both perfusion parameters (blood pressure and resulting flow) and stiffness (r = 0.95, 0.91), as well as fluidity (r = 0.96, 0.92). For the medulla, such significant (p &lt; 0.001) correlations were solely observed between the perfusion parameters and stiffness (r = 0.88, 0.71). Our findings demonstrate a strong perfusion dependency of renal stiffness and fluidity in an ex vivo setup. Moreover, changes in perfusion are rapidly followed by changes in renal mechanical properties—highlighting the sensitivity of tomoelastography to fluid pressure and the potential need for correcting mechanics-derived imaging biomarkers when addressing solid structures in renal tissue.
Morphological analysis of posterior-medial intertrochanteric fracture patterns using fracture-mapping technique
Authors: Ren Hanru , Zhang Xu , Liang Yakun , Yi Chengqing , Li Dejian 
Published: November 2023

Introduction: The purpose of this study was to analyze the fracture patterns of different posterior-medial wall types of intertrochanteric fractures by 3-D fracture-mapping technique and to further assess their clinical utility.Methods: In a retrospective analysis of interochanteric fractures treated in a large trauma center, fractures were classified into predesigned groups based on 3D-CT imaging techniques, and a 3-D template of the intertrochanteric region was graphically superimposed on the fracture line. Fracture characteristics were then summarized based on fracture-mapping. Finally, radiographic parameters, function, and range of motion were recorded in different fracture classification states.Results: A total of 348 intertrochanteric fractures were included. There were 111 patients (31.9%) in the posterolateral + posteromedial + medial group, with the most severe fracture displacement (typically characterized by fragmentation of the posteromedial wall into three isolated fragments). There were 102 cases (29.3%) in the posterolateral + posteromedial + simple medial group, and the most common fracture feature was a complete fragment posteromedially. A total of 81 cases (23.3%) were classified into the posterolateral + medial group, with the medial fracture line extending the anterior fracture line but leaving the lesser trochanter intact. In the isolated medial group of 33 cases (9.5%), the fracture type was similar to type IV, but the integrity of the greater trochanter was ensured. In the posteromedial + medial group of 12 cases (3.4%), the fracture was characterized by an interruption when the fracture line of the anterolateral wall extended to the posteromedial wall, often resulting in a complete isolated fragment posteromedially and medially. There were nine patients (2.6%) in the isolated posterolateral group. In addition, we found significantly different radiographic scores and range of motion scores between groups.Discussion: This morphometric study helps us to further characterize posterior-medial fracture patterns of intertrochanteric fractures, which may be closely related to different clinical outcomes. Further studies are needed to verify the reliability of this classification scheme in clinical application.
HPLC for simultaneous quantification of free mannose and glucose concentrations in serum: use in detection of ovarian cancer
Authors: Chen Yulong , Yao Qin , Zhang Lijuan , Zeng Pengjiao 
Published: November 2023

Background: Abnormal levels of monosaccharides in blood have been linked to tumorigenesis. In this study, a novel high-performance liquid chromatography (HPLC) method was established for the simultaneous determination of free mannose and glucose in the serum.Methods: The serum was directly derivatized by 1-phenyl-3-methyl-5-pyrazolone under alkaline conditions using L-rhamnose as an internal standard. The chromatographic separation was then performed on a Poroshell EC-C18 chromatographic column (4.6 × 100 mm, particle size 2.7 μm, Agilent) with gradient elution using NH4Ac-HAc and acetonitrile as the mobile phases. The method was thereafter validated according to international guidelines. The serum samples obtained from 200 healthy individuals and 200 ovarian cancer (OC) patients were analyzed for free mannose and glucose.Results: The method was found to be reproducible for quantification within 20 min and included online sample purification. The method displayed excellent linearity in the concentration range (for mannose: 0.5–500 μg/mL; glucose: 0.5–1500 μg/mL). The precision, recovery, and stability met the FDA bioanalytical method validation acceptance criteria. Overall, the measurement of glucose content by HPLC correlated well with the different enzymatic methods. Ovarian cancer mannose levels in the serum were significantly higher in the advanced stage (61.22 μmol/L, p &lt; 0.0001) than those in healthy volunteers and early-stage patients (44.51 μmol/L versus 50.09 μmol/L, p &lt; 0.0001). The AUC for the ratio of serum free glucose to mannose (G/M) was 0.98 (p &lt; 0.0001), with a sensitivity of 91.46% and a specificity of 98.50%, which served as a biomarker for OC diagnosis.Conclusion: We report a simple, repeatable, and attractive analytical method by HPLC, which can be used for quantitative estimation of free mannose and glucose simultaneously in human serum. Our results indicate that the serum level of mannose could be used as a potential biomarker of ovarian cancer.
Experimental study of a linear Fresnel reflection solar concentrating system
Authors: Zhang Qian , Chen Song , Yuan Bin , Huang Lei 
Published: November 2023

Introduction: In the field of solar energy utilization, the construction of low cost and easy to process large concentrated photothermal system is a scientific problem to be solved. A linear Fresnel reflection solar concentrator is proposed in this paper.Methods: The position, tilt angle and width of the glass mirrors placed in the same plane are different to ensure that all the reflected light falls on the flat focal plane or cylindrical focal surface. According to the focusing principle of the concentrator, two experimental system platforms ware built. When a flat focal plane is used to receive radiation from the sun, the intensity distribution of focal plane light spot is uniform in theory.Results: The CCD measurement method is used to analyze the concentrated light spot under experimental conditions, and it is proved that the energy flux density on the focal plane is uniform. Placing monocrystalline silicon cells on the focal plane, the experimental results of p-v power generation voltammetry show that the power generation efficiency of monocrystalline silicon cell does not decrease due to the uniform solar energy density, which can reach 17.1%. The photothermal experiment is carried out by using one-dimensional tracking mode of sunlight. The concentrator reflects the sun’s rays onto the vacuum collector tubes, heating the heat conduction oil flow in. The thermocouple measures the temperature of the heat conduction oil at the inlet and outlet of the vacuum collector tubes. The experimental photothermal conversion efficiency of this concentrator was analyzed and calculated through multiple groups of photothermal experiments, and compared with the theoretical concentrator efficiency. With two collector tubes in series, the theoretical photothermal conversion efficiency reaches 0.8 and the experimental photothermal conversion efficiency reaches about 0.74.Discussion: Because of its good concentrating performance and low cost, this type concentrator can be widely used in photothermal and photovoltaic applications.
Prefrontal cortex functional connectivity changes during verbal fluency test in adults with short-term insomnia disorder: a functional near-infrared spectroscopy study
Authors: Wu Peirong , Wang Chaowen , Wei Mindong , Li Yijiang , Xue Yuan , Li Xinrong , Jiang Jianfan , Bi Yinuo , Dai Jian , Jiang Wenyu 
Published: November 2023

BackgroundIndividuals suffering from short-term insomnia disorder (SID) experience difficulties in falling or staying asleep, often leading to daytime fatigue and impaired concentration. However, the underlying mechanisms of SID remain unclear. This study aims to investigate the alterations in brain activation patterns and functional connectivity in patients with SID.MethodsThe study enrolled a total of 31 adults diagnosed with SID and 31 healthy controls (HC). Functional near-infrared spectroscopy (fNIRS) was utilized to assess the concentrations of oxyhemoglobin (Oxy-Hb) and functional connectivity in the prefrontal cortex of each participant while performing the verbal fluency test (VFT) task.ResultsIn the VFT task, no significant difference was found between the SID group and the HC group in terms of integral values, centroid values, and mean Oxy-Hb variations. These findings suggest that both groups exhibit similar hemodynamic responses. However, the functional connectivity analysis revealed significant differences in inter-channel connectivity strength between the two groups. The SID group showed significantly lower average inter-channel connectivity strength compared to the HC group. Moreover, six channel pairs (right frontopolar cortex – left frontopolar cortex, left orbitofrontal cortex – left temporopolar cortex, left temporopolar cortex – left frontopolar cortex, left frontopolar cortex-Ch38, left frontopolar cortex – right pre-motor and supplementary motor cortex, and left frontopolar cortex – right dorsolateral prefrontal cortex) exhibited significantly higher connectivity strength in the HC group compared to the SID group (FDR corrected, p &lt; 0.05). Specifically, channel 27 exhibited the highest frequency of significant connectivity across different channel pairs, occurring five times in total. The channel pair Ch27-Ch39, representing left frontopolar cortex and right dorsolateral prefrontal cortex, exhibited a negative correlation with PSQI scores (r = −0.422, p = 0.018).ConclusionOur findings suggest that patients with SID may exhibit altered brain connectivity during the VFT task, as measured by fNIRS. These results provide valuable insights into the functional brain differences associated with SID. Further research is needed to validate and expand upon these findings.
Macronutrient intake and alertness during night shifts – the time interval matters
Authors: de Rijk Mariëlle G. , van Eekelen Alexander P. J. , Boesveldt Sanne , Kaldenberg Elly , Holwerda Tineke , Lansink Ceciel J. M. , Feskens Edith J. M. , de Vries Jeanne H. M. 
Published: November 2023

BackgroundWorking night shifts is associated with higher safety risks due to shift work-related fatigue. Nutrition, especially certain (macro) nutrient compositions, has been suggested to reduce fatigue, however, results of studies are contradictory. This could be explained by differences in the time interval investigated between the consumption of a meal and measurement of cognitive performance. Therefore, this observational study investigated the association between macronutrient intake and objective alertness at different time intervals during the night shift in nurses.Methods128 nurses, aged 20–61 years, completed an alertness test (Psychomotor Vigilance Task) during the night shift and a 24-h dietary recall after the night shift. This was repeated three times, always on the first night shift in a night shift series. The associations between macronutrient intake 0 to 1, 1 to 2, and 2 to 3 h before the PVT with alertness during the night shift were analyzed through Linear Mixed Models. The basic model was adjusted for age and gender and the adjusted model additionally for BMI, start time of PVT and energy and caffeine intake during the relevant time interval.ResultsProtein intake was not associated with objective alertness levels, while fat and carbohydrates intake had opposite associations with objective alertness levels over similar time intervals. Fat intake up to 1 h prior to the PVT was borderline associated with a longer median reaction time (RT) (ß = 9.00 ms/10 g fat, 95% CI: −0.21, 18.20), while a higher carbohydrate intake up to 1 h prior to the PVT was borderline associated with shorter median RTs (ß = −3.89, 95% CI: −7.85, 0.06). A higher fat intake 2 to 3 h prior to the PVT was associated with less lapses (log transformed ß = −0.16; 95% CI: −0.31, −0.02), while a higher carbohydrate intake 2 to 3 h prior to the PVT was associated with more lapses (ß = 0.06, 95% CI: 0.01, 0.12).ConclusionOur results contribute to understanding the association between macronutrient intake, as part of a mixed meal, and alertness levels. Conflicting results from previous studies may probably be due to time differences between macronutrient intake and alertness testing.
Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles ameliorate ulcerative colitis through antioxidant effects
Authors: Li Chunmei , Zhou Yu , Yuan Meng , Yang Yawen , Song Ruilong , Xu Gang , Chen Gang 
Published: November 2023

IntroductionAstaxanthin (AST) is a type of carotenoid with strong antioxidant effects. However, the development and use of AST are limited by its water insolubility and low bioavailability. This study aims to investigate whether AST@PLGA can inhibit UC and reveal its possible mechanism.MethodsWe tested the particle size, polydispersity index, and zeta potential of AST@PLGA. Then, the in vitro release and antioxidant capacity of AST@PLGA were tested. Finally, the mouse model of colitis was established and SOD, MDA, TNF-α, IL-1β, IL-6 and P38 as well as ERK were detected from mice.ResultsParticle size, polydispersity index and zeta potential of AST @PLGA were 66.78 ± 0.64 nm, 0.247 and -9.8 ± 0.53 mV, respectively, and were stable within 14 days. Then, it was observed that the AST@PLGA nanoparticles not only maintained the effect of AST but also had a sustained release effect. Experiments in mice showed that AST@PLGA effectively reduced MDA, TNF-α, IL-1β and IL-6 levels and increased SOD levels. AST@PLGA also downregulated the protein expression of P38 and ERK. The results showed the positive protective effect of AST@PLGA in inhibiting acute colitis.DiscussionAST@PLGA nanoparticles have good stability and alleviating effect in colitis, which could be functional foods in the future.
Case report: the dissociated response and clinical benefit of primary leiomyosarcoma of the bone treated with penpulimab plus lenvatinib after failed multi-line therapy
Authors: Wang Bin , Han Yin , Liu Jie , Zhang Xinyao , Zhuo Hongyu , Jiang Yu , Deng Yaotiao 
Published: November 2023

Leiomyosarcoma occurring in the bone as primary tumor localization is extremely scarce with limited cases described in the literature, accounting for less than 0.7% of all primary bone malignancies. Once distant metastasis occurs, patients have limited treatments and often a somber prognosis, which underscore the need for innovative and effective treatment approaches. The emerging evidence suggests that anti-angiogenic therapy could inhibit angiogenesis and normalize vascular permeability in the tumor microenvironment, which, in turn, would increase immune effector cell infiltration into tumors. Immunotherapy depends on the accumulation and activity of immune effector cells within the tumor microenvironment, and immune responses and vascular normalization seem to be reciprocally regulated. Immunotherapy combined with anti-angiogenic therapy has recently made great progress in the treatment of various types of tumors. However, the effectiveness of the combination treatment in metastatic leiomyosarcoma is undetermined. In this study, we presented a rare case of primary leiomyosarcoma of the bone located in the trochanteric region of the femur, accompanied by multiple distant metastases. After the failure of multi-line therapies including AI regiments as the adjuvant chemotherapy, anlotinib as the first-line therapy, GT regiment as the second-line therapy, and eribulin as the third-line therapy, the patient received combinational therapy with penpulimab plus lenvatinib. The best efficacy for this regimen was a partial response, with a progression-free survival of 8.4 months according to the iRECIST criteria. After a dissociated response was detected without severe toxicities, the patient received local radiotherapy and continued treatment on penpulimab plus lenvatinib and eventually achieved long-term survival benefits with a total of over 60 months of overall survival with good quality of life and ongoing treatment. As our previous retrospective study found that one-third of advanced STS patients could still achieve clinical benefits from rechallenge with multi-targeted tyrosine kinase inhibitors (TKIs), after the failure of previous TKI therapy, this case provided the potential clinical activity of immunotherapy combined with anti-angiogenic TKI rechallenge in metastatic leiomyosarcoma.
PENGARUH ESPEKTANSI UPAYA, EKSPEKTANSI KINERJA, DAN PENGARUH SOSIAL TERHADAP INTENSI PERILAKU STUDI IMPLEMENTASI MENU DIGITAL DI WEDANGAN ECHO SURAKARTA
Authors: Goutama Evin William , Leoparjo Fabiola , Soediro Moses 
Published: November 2023

Abstract. The objective of this study is to figure out how behavioral intention in the implementation of the digital menu at Wedangan Echo Surakarta is influenced by effort expectations, performance expectations, and social influence. The study's population consists of Wedangan Echo Surakarta customers who own smartphones. Furthermore, the study’s method of data collecting uses questionnaires distribution. In addition, the IBM SPSS 29.0.1.0 for Windows application is used to make significant inferences from the data outputs. This study concludes that effort expectations, performance expectations, and social influence all positively influence behavioral intention in the implementation of the digital menu at Wedangan Echo Surakarta.

Abstrak. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana behavioral intention dalam implementasi menu digital di Wedangan Echo Surakarta dipengaruhi oleh ekspektasi usaha, ekspektasi kinerja, dan pengaruh sosial. Populasi penelitian ini adalah pelanggan Wedangan Echo Surakarta yang memiliki smartphone. Selanjutnya, metode pengumpulan data penelitian ini menggunakan penyebaran kuesioner. Selain itu, aplikasi IBM SPSS 29.0.1.0 for Windows digunakan untuk membuat kesimpulan yang signifikan dari keluaran data. Penelitian ini menyimpulkan bahwa ekspektasi usaha, ekspektasi kinerja, dan pengaruh sosial semuanya berpengaruh positif terhadap niat perilaku dalam penerapan menu digital di Wedangan Gema Surakarta.