bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updated Intrinsic Role of Phytochemicals against Glyphosate-induced
Neurotoxicity: Systematic Review
Authors: Fan Ruitai , Zheng Yufei , YN Lakshmi Durga , Beeraka Narasimha M , Vikram P R Hemanth , Suhail Shaik Mohammed , Manjula Santhepete N. , Bannimath Namitha , Sinelnikov Mikhail Y , Liu Junqi 
Published: January 2024

Background:
Glyphosate-based herbicide (GBH) formulations are
organophosphorus pesticides implicated for agricultural use. Several epidemiological reports
have reported that the occupational exposure of farmers to glyphosate can cause
age-related neurodegeneration.

Objective:
the objective of this study is to examine the neurotoxic effects of glyphosate
and its intricate role in triggering several neurodegenerative diseases like dementia,
nootropic defects, Parkinson’s disease, and neurological teratogenic effects due to its
negative effects on the nervous system. Furthermore, the efficacy of phytochemicals
against glyphosate-induced neurotoxicity was discussed.

Methods:
We have searched public databases such as NLM, Pubmed, google scholar
and collected a total of 103 articles including reviews, original articles, and obtained information
related to glyphosate-induced neurotoxicity and novel phytochemicals implicated
to ameliorate the glyphosate-induced neurotoxicity. We performed a systematic review
without comprehensive meta-analysis.

Results:
the efficacy of several phytochemicals as a nutritional intervention against
glyphosate-induced neurotoxicity including Parkinsonism was elucidated by vivid review
analysis of neurobehavioral alterations from in vitro and in vivo study models.

Conclusion:
These kinds of research projects will bring awareness about the neurotoxic
effects of glyphosate and the protective nutritional intervention strategies against
glyphosate-induced neurotoxicity including Parkinsonism for farmers.
Current Understanding of Androgen Signaling in Prostatitis and its
Treatment: A Review
Authors: Cabeza Marisa 
Published: January 2024

Abstract:
Chronic prostatitis is a highly prevalent condition that significantly impacts
the quality of life and fertility of men. Because of its heterogeneous nature, there is no
definitive treatment, which requires ongoing research into its etiology. Additionally, the
association between prostatitis and an elevated risk of prostate cancer highlights the importance
of comprehending androgen involvement in prostatitis. This paper examines
the current understanding of androgen signaling in prostatitis and explores contemporary
therapeutic approaches. It was reviewed Medline articles comprehensively, using
keywords such as nonbacterial prostatitis, prostatitis infertility, androgen role in prostatitis,
and chronic pelvic pain. Several cellular targets are linked to androgen signaling.
Notably, the major tyrosine phosphatase activity (cPAcP) in normal human prostate is influenced
by androgen signaling, and its serum levels inversely correlate with prostate
cancer progression. Androgens also regulate membrane-associated zinc and pyruvate
transporters transduction in prostate cells, suggesting promising avenues for novel drug
development aimed at inhibiting these molecules to reduce cancer tumor growth. Various
therapies for prostatitis have been evaluated, including antibiotics, anti-inflammatory
medications (including bioflavonoids), neuromodulators, alpha-blockers, 5α-reductase
inhibitors, and androgen receptor antagonists. These therapies have demonstrated
varying degrees of success in ameliorating symptoms.In conclusion, aging decreases circulating
T and intraprostatic DHT, altering the proper functioning of the prostate, reducing
the ability of androgens to maintain normal Zn2+ levels, and diminishing the secretion
of citrate, PAcP, and other proteins into the prostatic fluid. The Zn2+-transporter decreases
or is absent in prostate cancer, so the pyruvate transporter activates. Consequently,
the cell ATP increases, inducing tumor growth.
Network Pharmacology Analysis and In Vitro Validation of the Active Ingredients and Potential Mechanisms of Gynostemma Pentaphyllum Against Esophageal Cancer
Authors: Guo Jianxin , Wu Zhongbing , Chang Xiaoyue , Huang Ming , Wang Yu , Liu Renping , Li Jing 
Published: January 2024

Background:
Esophageal cancer (EC) is one of the deadliest malignancies worldwide.
Gynostemma pentaphyllum Thunb. Makino (GpM) has been used in traditional Chinese medicine
as a treatment for tumors and hyperlipidemia. Nevertheless, the active components and underlying
mechanisms of anti-EC effects of GpM remain elusive.

Objective:
This study aims to determine the major active ingredients of GpM in the treatment of
EC and to explore their molecular mechanisms by using network pharmacology, molecular docking,
and in vitro experiments.

Methods:
Firstly, active ingredients and potential targets of GpM, as well as targets of EC, were
screened in relevant databases to construct a compound-target network and a protein-protein interaction
(PPI) network that narrowed down the pool of ingredients and targets. This was followed
by gene ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathway enrichment analyses. Next, molecular docking, ADME and toxicity risk prediction,
cell viability assays, in vitro scratch assays, Transwell cell invasion assays, and Western
blotting analysis were subsequently applied to validate the results of the network analysis.

Results:
The screening produced a total of 21 active ingredients and 167 ingredient-related targets
for GpM, along with 2653 targets for EC. The PPI network analysis highlighted three targets
of interest, namely AKT1, TP53, and VEGFA, and the compound-target network identified three
possible active ingredients: quercetin, rhamnazin, and isofucosterol. GO and EKGG indicated
that the mechanism of action might be related to the PI3K/AKT signaling pathway as well as the
regulation of cell motility and cell migration. Molecular docking and pharmacokinetic analyses
suggest that quercetin and isoprostanoid sterols may have therapeutic value and safety for EC.
The in vitro experiments confirmed that GpM can inhibit EC cell proliferation, migration, and
invasion and suppress PI3K and AKT phosphorylation.

Conclusion:
Our findings indicate that GpM exerts its anti-tumor effect on EC by inhibiting EC
cell migration and invasion via downregulation of the PI3K/AKT signaling pathway. Hence, we
have reason to believe that GpM could be a promising candidate for the treatment of EC.
Potential Role of Oxidative Stress in the Pathophysiology of Neurodegenerative Disorders
Authors: Singh Sonia , Ahuja Ashima , Pathak Shilpi 
Published: January 2024

Abstract:
Neurodegeneration causes premature death in the peripheral and central nervous system.
Neurodegeneration leads to the accumulation of oxidative stress, inflammatory responses,
and the generation of free radicals responsible for nervous disorders like amyotrophic lateral
sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disorders. Therefore, focus
must be diverted towards treating and managing these disorders, as it is very challenging. Furthermore,
effective therapies are also lacking, so the growing interest of the global market must
be inclined towards developing newer therapeutic approaches that can intercept the progression
of neurodegeneration. Emerging evidences of research findings suggest that antioxidant therapy
has significant potential in modulating disease phenotypes. This makes them promising candidates
for further investigation. This review focuses on the role of oxidative stress and reactive
oxygen species in the pathological mechanisms of various neurodegenerative diseases, amyotrophic
lateral sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disorders and
their neuroprotection. Additionally, it highlights the potential of antioxidant-based therapeutics
in mitigating disease severity in humans and improving patient compliance. Ongoing extensive
global research further sheds light on exploring new therapeutic targets for a deeper understanding
of disease mechanisms in the field of medicine and biology targeting neurogenerative disorders.
Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8
Nanoparticles
Authors: Shahidi Fatemeh , Naimi-Jamal M. Reza , Habibi Azizollah , Dekamin Mohammad G. 
Published: January 2024

Introduction:
Zeolitic imidazolate frameworks (ZIFs) play a crucial role among metalorganic
frameworks due to their highly desirable properties, including high surface area, appropriate
pore size, and excellent thermal and chemical stability.

Method:
In this study, ZIF-8 loaded with aspirin and coated using pectin (ZIF-8/Asp@Pectin) was
utilized as a suitable and effective platform for the drug delivery system. The preparation of this
coated MOF followed environmentally friendly methods, and aspirin was successfully loaded.

Result:
Characterization of the obtained ZIF-8/Asp@Pectin was performed using X-ray diffraction
(XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), Fourier Transform
Infrared (FT-IR) spectroscopy, and BET analysis.

Conclusion:
The release of aspirin from ZIF-8/Asp@Pectin was studied using UV–Vis spectroscopy
at 258 nm under in vitro conditions in HCl and PBS buffer solutions.
One Pot Synthesis of New Benzimidazole Derivatives with Exceptionally
High Luminescence Quantum Efficiency
Authors: Mensah Abraham , Liu Xin-Ye , Hu Bing-Xiang , Kweku Ennin Vendish , Wang Fang-Ming , Chen Li-Zhuang , Zheng Shao-Jun 
Published: January 2024

Aim and Objectives:
There are different approaches to the synthesis of benzimidazole. In this article, five new benzimidazole derivatives, BMPO, Me-BMPO, Di-MeBMPO, F-BMPO and Cl-BMPO where (BMPO=3-[(1H)-benzo[d]imidazol-2-yl]pyridin-2(1H)-one), have been prepared. Another study was carried out on luminescence properties and their potential applica-tions for the detection of transition metal ions.

Materials and Methods:
From the one-pot synthesis approach, all the derivatives of the benzim-idazole compounds were obtained. The compounds were characterized using HRMS, 1HNMR, 13CNMR, and X-ray crystallography. Herein, a mechanism has been deciphered by predicting the release of HCl(g).

Results:
All compounds showed a strong deep blue emission when dissolved in dimethylacetamide (DMA), with emission wavelengths at 423, 428, 435, 423, and 421 nm, and half-times of 3.64, 2.77, 2, 19, 3.42 and 3.52 ns, respectively. In addition, their emission quantum yields were deter-mined to be 72, 50, 42, 73 and 80%.

Conclusion:
Five new benzimidazole derivatives, BMPO, Me-BMPO, Di-MeBIPO, F-BIPO, and Cl-BIPO, have been successfully synthesized by the one-pot synthesis method, and their struc-tures are characterized and confirmed. The compounds exhibited exceptional luminescence by emitting a strong blue light in DMA with high fluorescence quantum yields between 42~80%.
Unifying Theory and Experiments: Multi-Target Pharmacology of Dajihan Pill Against Hyperlipidemia
Authors: Li Ning , Bian Canfeng , Gao Ya , Liu Lingfei , Hu Qin , Xiao Lixia , Guan Tianzhu 
Published: January 2024

Background:
The increasing incidence of hyperlipidemia (HLP) is attributed to the imbalance
in redox homeostasis, aberrant lipid metabolism, and the excessive intake of empty calories.
Dajihan Pill (DJHP) is a Traditional Chinese Medicine (TCM) formula composed of Zingiberis Rhizoma
(ZR), Piperis Longi Fructus (PLF), Alpiniae Officinarum Rhizome (AOR), and Cinnamomi
Cortex (CC) in a ratio of 3:2:3:2. It exhibits a significant preventive effect on HLP. Certainly, the
active components and the precise mechanism of action are not fully understood. Therefore, this
study aims to elucidate the preventive and ameliorative mechanisms of DJHP against HLP by integrating
network pharmacology, molecular docking, and experimental validation.

Methods:
Based on the pharmacological method, active ingredients in DJHP and targets were extracted
from Traditional Chinese Medicine System Pharmacology (TCMSP) and UniProt. Then core
compounds and targets were obtained by constructing “compounds-targets-disease” and proteinprotein
interaction (PPI) network. Gene Ontology (GO) function analysis and Kyoto Encyclopedia of
Genes and Genomes (KEGG) were employed to elucidate further the associated action mechanism.
The molecular binding mechanisms between the core ingredients and targets were elucidated through
molecular docking. Additionally, the antioxidant capacities of DJHP extracts were investigated by
assessing their DPPH, hydroxyl, and ABTS radical scavenging activities.

Results:
A total of 45 active compounds and 258 targets were identified in DJHP. Network analysis
indicated that quercetin, beta-sitosterol, kaempferol, and oleic acid might serve as core bioactive
compounds. Seven core targets, including AKT1, INS, and TNF, were identified as potential preventive
targets. GO analysis suggested the improvement of HLP by DJHP may be related to the lipid
metabolic process, high-density lipoprotein particle, triglyceride binding, and inflammatory response.
The KEGG analysis indicated TNF, HIF-1, and AMPK signaling pathways were involved.
The observations of active compounds binding with core targets indicated an excellent combination.
Additionally, antioxidant results showed that DJHP exhibited significant DPPH, hydroxyl, and
ABTS radical scavenging activities.

Conclusion:
Theoretical and experimental investigations indicate that DJHP can effectively modulate
various signaling pathways and enhance the redox system, thus mitigating HLP. Our work provided
a basis for the pharmacological study of DJHP in preventing HLP and further research.
The Molecular Docking and Molecular Dynamic Effects of Omeprazole on CDKs 2, 4, and 6 as a Potential CDK Inhibitor in Cancer Treatment
Authors: Jamali Navid , Mohseni Roohollah , Zareei Mansoor , Saffari-Chaleshtori Javad 
Published: January 2024

Introduction:
Cyclin-dependent kinases (CDKs) are serine/threonine kinase proteins that
regulate the cell cycle through phosphorylation and dephosphorylation. These proteins are a main
target in cancer therapy. This study investigated the effect of omeprazole on CDK2, CDK4, and
CDK6 through simulation studies.

Methods:
To investigate the interaction between omeprazole and CDK2, 4, and 6, the threedimensional
structure of omeprazole was obtained from PubChem, and the structures of CDK2, 4,
and 6 were acquired from RCSB servers. The proteins were then simulated for 50 nanoseconds using
the GROMACS 2021 platform before the docking process. Next, Autodock v.4.2.6 software was used
to bind omeprazole as a ligand to these proteins, and a molecular dynamics simulation of the resulting
protein-ligand complex was conducted using GROMACS after the docking process.

Results:
Omeprazole exhibited a high affinity for interacting with CDK2, 4, and 6, mainly occurring
in the ATP binding site of CDK4. However, the docking of omeprazole in the CDKs induced conformational
changes in their structures, which could potentially affect their function and lead to cell
cycle arrest.

Conclusion:
Omeprazole, which is a proton pump inhibitor, can induce cell cycle arrest by interacting
with the ATP-binding site of CDK4. Moreover, it can also induce conformational changes in
CDK2, CDK4, and CDK6 through high-affinity interactions with specific amino acid residues.
Prevalence of Bruxism in Children and Adolescents with Cerebral Palsy: Systematic Review and Meta-analysis
Authors: Kanhouche Nathalia , Pizzi Gabriela Godoy , Bim Nathalia Araujo , de Souza Rafael Celestino , Calvo Ana Flávia Bissoto , Floriano Isabela , Gimenez Thais , Imparato José Carlos Pettorossi , Tedesco Tamara Kerber 
Published: January 2024

Aims:
To perform a systematic review and meta-analysis compiling data on the prevalence
of bruxism in children and adolescents with cerebral palsy.

Methods and Results:
Searches were carried out in PubMed/Medline, Web of Science, and Scopus
databases to identify the articles published by February 2023. Two independent reviewers,
and in duplicate, employed a two-stage process to select publications. The same two reviewers performed
the data extraction. Studies were included when the following eligibility criteria were met:
performed in children and/or adolescents with cerebral palsy and reporting bruxism. Potentially eligible
studies were read in full and excluded that: not presented numerical data on the prevalence
of bruxism; not reported how the bruxism was assessed; not reported data about the cerebral palsy;
and not an observational study. The risk assessment of bias was assessed by the Newcastle-
Ottawa Scale. After reading the titles and abstracts of the 358 identified articles, eight articles
from 1966 to 2020 were included. The main reason for not including the studies was not to report
data about bruxism (59.3%), and 44.5% were excluded for not reporting data from patients
with cerebral palsy. The studies were carried out in schools, university hospitals, or centers for patients
with special needs (Brazil, the United States, and Egypt). The pooled prevalence of bruxism
in children and adolescents with cerebral palsy was 46% (95%CI: 0.38-0.55) after removing one
study.

Conclusion:
The pooled prevalence of bruxism in children with cerebral palsy can be considered
high since almost half of the studied population is affected by this condition. PROSPERO
#CRD42021225781.
Missed Opportunities in Type 2 Diabetes Mellitus: A Narrative Review
Authors: Kwok Chun Shing , Phillips Anne , Mukherjee Supriyo , Patel Mahendra G. , Hanif Wasim 
Published: January 2024

Background:
Type 2 diabetes mellitus (T2DM) is a significant health problem around
the world.

Objective:
This review aims to define missed opportunities and how they apply to patients with
T2DM.

Method:
This narrative review describes the natural history of T2DM and also describes where
missed opportunities may arise.

Results:
Missed opportunities may relate to prevention, early detection, diagnosis, and treatment
of diabetes. The cornerstone of T2DM prevention is the control of modifiable risk factors and
lifestyle changes to potentially prevent diabetes. Early detection of T2DM is important as it is a
chronic condition that can progress rapidly if untreated. Missed opportunities related to the diagnosis
of T2DM draw attention to the heterogeneous presentation of diabetes. The condition can be
incidentally identified in asymptomatic patients, so all healthcare professionals should be aware of
the disease. Furthermore, it is not unexpected that patients with atypical symptoms may have a
delay in diagnosis. The treatment-related missed opportunities in T2DM are broad and include
self-care, education, remission of T2DM, risk factor management, prevention of complications,
medication therapy and compliance, as well as individualized care. Considering patient pathways
is a useful approach to evaluate missed opportunities in patient care.

Conclusion:
Missed opportunities are a concept that is not often considered in diabetes care, which
calls upon reflection of real-world activities and consideration of whether patient outcomes could
have been improved with changes in decision-making. Future studies that aim to improve patient
care should consider this concept.
Overview of Dietary Supplements Use: A Narrative Review
Authors: Hasan Mariam , Allehdan Sabika , Alalwan Tariq , Perna Simone , Tayyem Reema 
Published: January 2024

Abstract:
Dietary supplements are ingestible nutrient products used in individuals’ diets to meet
their adequate intake of nutrients required for general health purposes. This review aims to explore
the impact of using dietary supplements in relation to communicable and non-communicable
diseases, as well as some adverse effects caused by dietary supplements. Findings indicated that vitamin
D supplements can aid in recovery from flu and COVID-19. Folic acid can reduce stroke incidents
among adults with hypertension. Moreover, vitamin C or calcium intake is significantly associated
with lowering diabetes risk. Advantageous effects have been reported of high doses of vitamin
C against breast cancer. Moreover, frequent consumption of vitamin E reduced the risk of
chronic lung diseases by 10%. In conclusion, the present review confirms the beneficial health effects
of dietary supplement consumption and suggests further investigations for a better understanding
of their mechanisms in the prevention and treatment of communicable and non-communicable
diseases.
Neuroprotective Effect of Boswellia serrata against 3-NP Induced Experimental
Huntington’s Disease
Authors: Kumar Vinay , Sharma Chanchal , Taleuzzaman Mohamad , Nagarajan Kandasamy , Haque Anzarul , Bhatia Mamta , Khan Sumayya , Salkini Mohamad Ayman , Bhatt Pankaj 
Published: January 2024

Objectives:
The study aimed to assess the neuroprotective effect of Boswellia serrata
against 3-NP-induced experimental Huntington’s disease.

Background:
Previous studies have shown Boswellia to have sedative, analgesic, and anti-tumour
effects. Boswellia serrata yields four pentacyclic triterpene acids and boswellic acid, a bioactive
substance that prevents leukotriene biogenesis.

Methods:
The potential neuroprotective effect of Boswellia serrata against 3-nitro propionic acid
(3-NP)-induced Huntington's disease (HD) was examined at oral doses of 45 mg/kg, 90 mg/kg,
and 180 mg/kg. In this study, HD was induced by 3-NP at a dose of 10 mg/kg in Wistar rats. The
study used 56 Wistar rats (8 per group) for biochemical (inflammatory markers, acetylcholinesterase
activity) and behavioural (elevated plus maze, Y-maze, open-field, tail suspension tests,
etc.) assessments. Additionally, a histological examination of the brain was carried out. In addition,
the analysis of Boswellia serrata extract was performed by different analytical techniques,
like UV spectrophotometer, FTIR, and HPLC methods.

Results:
In the brain, succinate dehydrogenase is a mitochondrial enzyme irreversibly inhibited
by 3-NP. Administration of 3-NP resulted in HD with altered behavioural and motor changes
in rats. Treatment with Boswellia serrata resulted in remarkable protection of rats against
3-NP-induced behaviour and motor deficits in a dose-dependent manner. Moreover, in rats
administered with 3-NP, Boswellia serrata improved memory performance and lowered levels of
inflammatory biomarkers. These results have also been supported by histopathological analysis.
Acetyl-11-keto-p-boswellic acid was found to be the main active component of Boswellia serrata
extract.

Conclusion:
Boswellia serrata at a dose of 180 mg/kg exhibited better protection compared to the
other doses against HD induced by 3-NP. More detailed studies based on molecular targets are
needed for the Boswellia serrata to transition from the bench to the bedside for use as an adjuvant
in HD patients.