bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of immunotherapy in patients with metastatic melanoma
Authors: Lyadova M. A. , Fedorinov D. S. , Nosova M. V. , Tuleiko V. M. , Orlova A. S. , Vozniuk D. A. , Lyadov K. V. , Galkin V. N. 
Published: January 2024

Introduction. Melanoma is an aggressive form of skin cancer caused by the transformation of melanocytes into malignant cells. Currently, immunotherapy is one of the most promising treatment methods, but searching the most optimal treatment regimens is still ongoing.Objective. To evaluate the effectiveness and safety of the use of immune checkpoint inhibitors (ICIs) in patients with metastatic melanoma.Materials and methods. The study included 229 patients (114 men and 115 women) aged 21 to 91 years who received (ICIs) as nivolumab (n = 168; 73,4%) and pembrolizumab (n = 30; 13,1%) monotherapy, and combination of nivolumab and ipilimumab (n = 31; 13,5%). The objective response of the tumor to treatment was recorded in the presence of partial or complete regression of the tumor. The tumor response to treatment was determined in accordance with the iRECIST criteria.Results. Complete regression was observed in 16.7, 15.9 and 8,7% of patients, partial – in 11.1, 11.4 and 17.4%, stabilization was detected in 51.2, 50.0 and 34.8% and progression – in 21.0, 22.7 and 39.1% of patients with first, second and third and more-line setting, respectively. The median response time was 3.14, 5.18 and 3.63 months, the median response duration was 16.21, 8.96 and 30.15 months in first, second and third and more-line setting, respectively. Grade 3–4 immuno-related adverse events (irAEs) were observed in 8 (3.5%) patients.Conclusions. Immunotherapy of metastatic melanoma allows achieving high rates of objective response and disease control (27.5 and 76.9%, respectively). This method of treatment is characterized by an insignificant amount of grade 3–4 irAEs (3.5% according to our data), which indicates an acceptable safety profile.
Studying the effect of high-protein nutritional support on postoperative outcomes and during adjuvant chemotherapy in patients with primary gastric cancer
Authors: Khagazheeva M. N. , Snegovoy A. V. , Kelemetov A. M. , Tatyanin V. O. , Starostin N. M. 
Published: January 2024

Introduction. Malnutrition of cancer patients is a big problem today. This is especially evident in patients with tumors of the gastrointestinal tract, where the frequency of this condition reaches high values. Malnutrition has a direct negative impact on the tolerability of treatment, long-term results and quality of life of this category of patients, so it is important to identify this condition and, if possible, correct it.Aim. To evaluate the effect of protein nutritional support on blood counts, prolongation of intervals between chemotherapy courses, postoperative complications, progression-free life expectancy and OS in patients with gastric cancer after surgical treatment and during adjuvant chemotherapy.Materials and methods. The study included 106 patients with gastric cancer who received surgical treatment followed by postoperative chemotherapy according to the XELOX regimen. The patients were divided into 2 groups: in the first group, patients received additional protein nutrition (Nutridrink Compact Protein) both before and after surgical treatment, and during chemotherapy; in the second group, patients did not receive nutritional support – the control group.Results. Median levels of leukocytes, neutrophils and platelets during treatment were higher in group 1. Surgical complications in the group with nutritional support occurred significantly less frequently than in the control group, the same applies to complications after chemotherapy. During treatment, lengthening of the intervals between courses occurred statistically significantly more often in group 2 (without protein nutrition). 4-year overall survival was statistically higher in the protein diet group. The median PFS in patients from the first group was higher and amounted to 55.6 months, in the second group – 46.7 months.Conclusion. The presence of additional protein nutrition is an independent factor in the prognosis of the disease, since it significantly increases both relapse-free and overall survival of patients.
An Evaluation Analysis for Computed Tomography Image Quality of Primary
Liver Cancer Lesions Based on Deep Learning Image Reconstruction
Authors: Sun Yan , Sun De-zheng , Han Chun-Lei 
Published: January 2024

Background:
Abdominal multi-slice helical CT and contrast-enhanced scanning have been widely recognized clinically.

Objective:
The impact of the deep learning image reconstruction (DLIR) on the quality of dynamic contrast-enhanced computed tomography (CT) imaging of primary liver cancer lesions was evaluated through comparison with the filtered back projection (FBP) and the new generation of adaptive statistical iterative reconstruction-V (ASIR-V).

Methods::
We evaluated the image noise of the lesion, fine structures inside the lesion, and diagnostic confidence in 48 liver cancer subjects. The CT values
of the solid part of the lesion and the adjacent normal liver tissue and the systolic and diastolic blood pressure (SD) values of the right paravertebral
muscle were measured. The muscle SD value was considered as the background noise of the image, and the signal noise ratio (SNR) and contrast
signal-to-noise ratio (CNR) of the lesion and normal liver parenchyma were calculated.

Results::
High consistency in the evaluation of image noise (Kappa = 0.717). The Kappa values for margin/pseudocapsule, fine structure within the lesion,
and diagnostic confidence were 0.463, 0.527, and 0.625, respectively. Besides, the differences in SD, SNR and CNR data of reconstructed lesion
images among the six groups were statistically significant.

Conclusion::
The contrast-enhanced CT image noise of DLIR-H in the portal venous phase is much lower than that of ASIR-V and FBP in primary liver cancer
patients. In terms of the lesion structure display, the new reconstruction algorithm DLIR is superior.
Morphological Correlation between the Diameters of the Left Main Coronary
Artery and its Branches Measured by QCA and Derived by Finet’s Law
Authors: Rezigalla Assad Ali 
Published: January 2024

Background::
Coronary artery diseases are the leading cause of death worldwide. Stenting or angioplasty of coronary arteries as interventional management
requires knowledge about the morphology of the coronary tree, including luminal diameters.

Objective::
This work aimed to study the diameters of the left main coronary artery and its branches measured by QCA in relation to the diameters derived by
Finet’s law.

Methods::
This was a cross-sectional, retrospective, hospital-based study. The number of angiograms used was 357. The diameters of the left main coronary
artery (LM1), left anterior interventricular artery (LAD1), and left circumflex artery (LCx1) were measured by QCA. The diameter of LM1 was
measured by 5 mm before its termination, and the diameters of LAD1 and LCx1 were obtained by 5 mm from their origins. Finet’s law was used to
calculate the diameters of LM2, LAD2 and LCx2 using the QCA measurements.

Results::
The mean age of participants was 53.3±8.8 years. Female patients represented 58.9%. The mean diameter of the left main coronary using QCA was
3.75±0.85 mm, and the diameter calculated using Finet’s law was 3.89±0.80 mm. The diameters of LAD1 and LCx1 were larger than those
calculated with Finet’s law. The Z-test showed a significant difference between the diameter of the LM1 calculated by Finet’s law; both diameters
were positively associated. The diameters of LAD1 and LAD2 showed a non-significant correlation (r = 0.0653, P = 0.259526) and a negative
correlation between LCx1 and LCX2 (r = -0.2659, P = 0.00001). The Z-test showed a significant difference in the diameter of LAD and LCx
measured by QCA and Finet’s law.

Conclusion::
An association was found between the diameter of LM measured by QCA and calculated with Finet’s law; the diameter calculated by Finet’s law
was larger. The diameters of LAD and LCx measured by QCA were larger than those calculated by Finet’s law. A positive correlation existed
between the diameters measured by QCA and Finet’s law, and they had significant differences. Finet’s law can assist in the selection of stent size.
Despite the literature about Finet’s law, generalising its use requires more studies on different ethnicities.
Depression and Anxiety in Adolescents During the COVID-19 Pandemic in Relation to the Use of Digital Technologies: Longitudinal Cohort Study
Authors: Shen Chen , Smith Rachel B , Heller Joel , Spiers Alexander D V , Thompson Rhiannon , Ward Helen , Roiser Jonathan P , Nicholls Dasha , Toledano Mireille B 
Published: January 2024

Background
Adolescents are susceptible to mental illness and have experienced substantial disruption owing to the COVID-19 pandemic. The digital environment is increasingly important in the context of a pandemic when in-person social connection is restricted.

Objective
This study aims to estimate whether depression and anxiety had worsened compared with the prepandemic period and examine potential associations with sociodemographic characteristics and behavioral factors, particularly digital behaviors.

Methods
We analyzed cross-sectional and longitudinal data from a large, representative Greater London adolescent cohort study: the Study of Cognition, Adolescents and Mobile Phones (SCAMP). Participants completed surveys at T1 between November 2016 and July 2018 (N=4978; aged 13 to 15 years) and at T2 between July 2020 and June 2021 (N=1328; aged 16 to 18 years). Depression and anxiety were measured using the Patient Health Questionnaire and Generalized Anxiety Disorder scale, respectively. Information on the duration of total mobile phone use, social network site use, and video gaming was also collected using questionnaires. Multivariable logistic regression was used to assess the cross-sectional and longitudinal associations of sociodemographic characteristics, digital technology use, and sleep duration with clinically significant depression and anxiety.

Results
The proportion of adolescents who had clinical depression and anxiety significantly increased at T2 (depression: 140/421, 33.3%; anxiety: 125/425, 29.4%) compared with the proportion of adolescents at T1 (depression: 57/421, 13.5%; anxiety: 58/425, 13.6%; P for 2-proportion z test <.001 for both depression and anxiety). Depression and anxiety levels were similar between the summer holiday, school opening, and school closures. Female participants had higher odds of new incident depression (odds ratio [OR] 2.5, 95% CI 1.5-4.18) and anxiety (OR 2.11, 95% CI 1.23-3.61) at T2. A high level of total mobile phone use at T1 was associated with developing depression at T2 (OR 1.89, 95% CI 1.02-3.49). Social network site use was associated with depression and anxiety cross-sectionally at T1 and T2 but did not appear to be associated with developing depression or anxiety longitudinally. Insufficient sleep at T1 was associated with developing depression at T2 (OR 2.26, 95% CI 1.31-3.91).

Conclusions
The mental health of this large sample of adolescents from London deteriorated during the pandemic without noticeable variations relating to public health measures. The deterioration was exacerbated in girls, those with preexisting high total mobile phone use, and those with preexisting disrupted sleep. Our findings suggest the necessity for allocating resources to address these modifiable factors and target high-risk groups.
Estudo do potencial nutricional e funcional de frações do jambolão syzygium cumini (l.): uma revisão
Authors: Silva Souza Lauriane , Macêdo Viana Eduardo Bruno , De Lima Silva dos Santos Carla Állyssa , Souza Ribeiro Jéssica , Camelo Eloi de Souza Cassiara , Elena Zanuto Marcia 
Published: January 2024

O objetivo do estudo foi abordar a composição química, teor de bioativos e potencial nutricional e terapêutico de diferentes partes do fruto de Syzygium cumini (L.) (jambolão). Foi realizada uma revisão bibliográfica, utilizando três bases de dados eletrônicas (Science Direct, Google Acadêmico e PubMed) e descritores de características química, bioativos e funcionalidade. Foram identificados 241 artigos, publicados entre 2011 a 2021, dos quais 34 artigos foram selecionados para compor a presente revisão. Dos 34 (100%) artigos encontrados, 21 (61,76%) foram realizados no Brasil, 10 (29,41%) na Índia, 1 (2,94%) na China, 1 (2,94%) em Bangladesh e 1 (2,94%) no Paquistão. Das características físico-químicas e químicas observou-se maior número de trabalhos com a polpa do jambolão. Entretanto as sementes se destacaram quanto ao teor de proteína, lipídeos, fibras e carboidratos. Quanto aos bioativos presentes na polpa com casca e semente do jambolão, os principais foram os compostos fenólicos, antocianinas e taninos. O jambolão também mostrou diversas propriedades funcionais como a atividade antidiabética, principalmente na semente do fruto, função antioxidante, ação antineoplásica, ação anti-hiperlipidêmica, cardioprotetora, antibacteriana, antiobesidade e anti-hipertensiva. Conclui-se que as partes do fruto estudadas apresentam elevado valor nutricional e diversas funcionalidades, mostrando potencial para serem integradas a dieta em sua forma in natura, quanto processada, agregando maior valor a esta espécie medicinal “jambolão”.
Residential Address Amplifies Health Disparities and Risk of Infection in Individuals With Diabetic Foot Ulcers
Authors: Schmidt Brian M. , Huang Yiyuan , Banerjee Mousumi , Hayek Salim S. , Pop-Busui Rodica 
Published: January 2024

OBJECTIVE
To determine the association between social determinants of health (SDOH) and a diagnosis of diabetic foot ulcer (DFU) infection.

RESEARCH DESIGN AND METHODS
Targeted interrogation of electronic health record data using novel search engines to analyze individuals with a DFU infection during a 5-year period (2013–2017) was performed. We extracted geolocated neighborhood data and SDOH characteristics from the National Neighborhood Data Archive and used univariate and multiple logistic regression to evaluate associations with outcomes in the population with diabetes.

RESULTS
Among 4.3 million people overall and 144,564 individuals with diabetes seen between 2013 and 2017, 8,351 developed DFU, of which cases 2,252 were complicated by a DFU infection. Sex interactions occurred, as men who experienced a DFU infection more frequently identified as having nonmarried status than their female counterparts. For the population with DFU infection, there were higher rates for other SDOH, including higher neighborhood disadvantaged index score, poverty, nonmarriage, and less access to physician/allied health professionals (all P &lt; 0.01). In multiple logistic regression, those individuals who developed DFU infection came from neighborhoods with greater Hispanic and/or foreign-born concentrations (odds ratio 1.11, P = 0.015).

CONCLUSIONS
We found significant differences in neighborhood characteristics driving a higher risk for DFU infection in comparisons with the grouping of individuals with diabetes overall, including increased risk for individuals with Hispanic and/or foreign-born immigration status. These data strongly support the need to incorporate SDOH, particularly ethnic and immigration status, into triage algorithms for DFU risk stratification to prevent severe diabetic foot complications and move beyond biologic-only determinants of health.
Peran Perawatan Paliatif Anak pada End-of-Life
Authors: Andriastuti Murti , Dyaningsih Tisa Paramita Sari 
Published: January 2024

Menurut World Health Organization, perawatan paliatif didefinisikan sebagai pencegahan, dan tata laksana untuk mengatasi penderitaan pasien dan keluarganya dalam menghadapi penyakit yang mengancam jiwa. Pada tahun 2011 65,5% negara tidak memiliki perawatan paliatif untuk anak. Sajian kasus berbasis bukti ini bertujuan untuk membandingkan efektivitas, dan manfaat dari intervensi perawatan paliatif serta tanpa perawatan paliatif di masa akhir kehidupan pada anak dengan penyakit berat. Pencarian literatur secara online menggunakan database Pubmed, EBSCO, dan Cochrane melalui metode PICO. Seluruh artikel diseleksi terlebih dahulu sesuai kriteria eligibilitas. Satu artikel menunjukkan permintaan pasien untuk tidak dilakukan resusitasi/DNR saat terjadi perburukan 8 kali lebih besar dengan pendampingan paliatif (rasio odd disesuaikan 7,92; 95% CI 2,02-31,12). Artikel lain didapatkan bahwa pasien dengan perawatan paliatif pada kondisi menjelang kematian cenderung dalam status DNR (rasio odd 7,71; P<0,001). Intervensi tim paliatif pada pasien di akhir kehidupan memfasilitasi pengambilan keputusan besar untuk tidak dilakukannya resusitasi dibandingkan pada pasien tanpa perawatan paliatif.
Asta Brata Moderates Budget Planning, Experience and Regulation of Budget Absorption during the Covid-19 Period
Authors: Supraptana I Putu Deari , Sujana Edy 
Published: January 2024

PTN BLU Udayana University as one of the BLU state universities by managing very large funds has experienced a decrease in budget absorption in the last three years which indicates that the planned activities cannot be realized properly. The purpose of this study is to test and analyze the effect of budget planning, experience and regulation on budget absorption and to test and analyze asta brata reinforce the influence of budget planning, experience and regulation on budget absorption. The population of this study is the entire Treasurer of Auxiliary Expenditures (BPP) and members of the Treasurer of Auxiliary Expenditures (BPP) based on the Decree of Power of Attorney for the Use of Budget of Udayana University Number 17 / UN14 / HK / 2022, which is 76 people, as well as verifier 2 and validators in this case serving as Head of Administration, Deputy Dean II and Deans of 48 people. So a total of 124 people. The sampling used is a census technique. The data collection method used in this study was to use a questionnaire. Data analysis in this study used the help of Smart PLS 3.2.9 software. The results of the analysis show that Budget planning has a positive and significant effect on budget absorption, while experience and regulation have no significant effect on budget absorption. The results also show that Asta brata is unable to moderate the influence of budget planning, experience and regulation on budget absorption.
Measuring the Boundaries of Criminal Liability for Obscene Acts in Medical Treatments (Case Study of Decision Number 114/Pid.Sus/2021/PN.Idi)
Authors: Ohoiwutun Y.A. Triana , Sapti Prihatmini  , Windy Puri Astuti  , Aleya Zeneizha  
Published: January 2024

ABSTRACT
Objectives of the study: This study examined the boundaries of criminal liability for the obscene act of doctors in providing medical treatments to patients beyond their authority. In addition, this study further investigated the panel of judge ratio decidendi towards the case.
Methodology: This study employed a doctrinal method with a statutory approach, a conceptual approach, and a qualitative analysis.
Results: The defendant's actions in Decision Number 114/Pid.Sus/2021/PN.Idi is categorized as malpractice or obscene acts, in which determining parameters are related to acts of violation of medical ethics, medical discipline and/or violations of criminal law. The assessment of the boundaries of criminal liability of doctors in the process of proving a case in court requires information from examination sessions by the MKEK and/or MKDI institutions. The role of MKEK and/or MKDI is urgent; however, their authorities are dissimilar, and the results of their examinations do not bind the criminal court decision.
Applications of this study: This study evaluated the liability of doctors in both criminal and ethical liability. In addition, this study serves as an evaluation tool for judges' logical approach.
Novelty/ Originality of this study: This study examined the criminal and ethical liability of doctors in a case study.
Keywords: Malpractice, Standard Operating Procedure, Competency Standard
ABSTRAK
Tujuan: Penelitian ini mengkaji batas-batas pertanggungjawaban pidana atas perbuatan cabul dokter dalam memberikan perawatan medis kepada pasien di luar kewenangannya. Selain itu, penelitian ini menyelidiki lebih lanjut tentang pertimbangan majelis hakim (rasio decidendi) terhadap kasus tersebut.
Metodologi: Penelitian ini menggunakan metode doktrinal dengan pendekatan statute (perundang-undangan), pendekatan konseptual, dan analisis kualitatif.
Temuan: Tindakan tergugat dalam Putusan Nomor 114/Pid.Sus/2021/PN.Idi dikategorikan sebagai malpraktik atau perbuatan cabul, dimana parameternya mengacu pada tindak pelanggaran etika kedokteran, disiplin kedokteran, dan/atau pelanggaran hukum pidana. Penilaian batas-batas pertanggungjawaban pidana dokter dalam proses pembuktian suatu perkara di pengadilan memerlukan keterangan dari sesi pemeriksaan yang dilakukan oleh lembaga MKEK dan/atau MKDI. Peran MKEK dan/atau MKDI sangat penting, namun kewenangan dua lembaga tersebut berbeda, dan hasil pemeriksaan dua lembaga ini tidak mengikat pada putusan MK.
Kegunaan: Penelitian ini mengevaluasi tanggung jawab dokter dalam pertanggungjawaban pidana dan etika. Selain itu, penelitian ini berfungsi sebagai alat evaluasi untuk pendekatan logis para hakim.
Kebaruan/Orisinalitas: Penelitian ini mengkaji tanggung jawab pidana dan etika para dokter dalam sebuah studi kasus.
Kata kunci: Malpraktik, Standar Operasional Prosedur, Standar Kompetensi
ANALISIS RISIKO KESELAMATAN DAN KESEHATAN KERJA (K3) DENGAN METODE JOB SAFETY ANALYSIS (JSA) PADA PEMBANGUNAN SALURAN 5 TAHAP 3 DI PT. KRAKATAU SARANA PROPERTI
Authors: Dhena Ria Barleany Akbar Gunawan, Sabili Ikhwananda, , Ikhwananda Sabili , Barleany Dhena Ria 
Published: January 2024

Kemajuan industri di Indonesia saat ini semakin maju dan kemajuan tersebut belum diimbangi dengan perhatian terhadap pemahaman dan penyelesaian keselamatan kerja secara tepat. Setiap kegiatan kerja pasti akan memiliki potensi bahaya yang dapat mengancam keselamatan dan kesehatan kerja. Menemukan dan mengidentifikasi potensi bahaya, menilai tingkat risiko dan mengevaluasi langkah-langkah yang telah dilakukan untuk mengendalikan risiko pada pembangunan saluran kerenceng 5 tahap 3 dengan menggunakan metode Job Safety Analysis (JSA). 7 sumber yang menimbulkan potensi bahaya yaitu pekerja yang tidak
memakai alat pelindung diri (APD) pada saat pemecahan batu, jembatan yang tidak aman, menyusun batu, puing-puing batu yang berserakan, pekerja yang tidak menggunakan APD saat pengadukan semen dengan mesin, tanah yang tidak rata dan alat berat penggali yang telalu dekat dengan pekerja Pada potensi bahaya yang disebabkan oleh tanah yang tidak rata di pembangunan saluran, memiliki risiko bahaya adalah terpelosok dan melukai pekerja yang melewati. Maka dilakukan pengendalian eliminasi dengan cara meratakan tanah atau diberi palang dan tanda. Pada potensi bahaya yang disebabkan oleh alat berat penggali yang terlalu dekat dengan pekerja di pembangunan saluran kerenceng 5 tahap 3,memiliki risiko bahaya adalah pekerja yang melewatinya bisa terkena alat berat penggali. Maka dilakukan pengendalian teknologi dengan cara memberikan batas berupa palang dan tanda