bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between e-cigarette use and myocardial infarction: a systematic review and meta-analysis
Authors: Ashraf Muhammad Talal , Shaikh Asim , Khan Muhammad Khuzzaim Shakeel , Uddin Naseer , Kashif Muhammad Arham bin , Rizvi Syed Hassan Ahmed , Khalid Hammad , Sam Stafford Jude , Sohail Affan 
Published: November 2023

Abstract
Background
The popularity of e-cigarettes has risen dramatically over the last few years, particularly among the younger population. Although the use of combustible cigarettes has established evidence to be associated with the development of several adverse cardiopulmonary diseases, the investigations regarding the prospective long-term effects of e-cigarette use on the cardiovascular system have just begun. We set to investigate if there is an association between the history of MI and e-cigarette use among smokers and non-smokers?

Methods
The current review aims to assess the association of myocardial infarction with e-cigarette consumption. PubMed, Google Scholar, and Cochrane Central Register of Controlled Trials (CENTRAL) were queried up to October 2022 to identify articles assessing the incidence of myocardial infarction among e-cigarette users. Data were meta-analyzed using a random-effects model to derive odds ratios (OR) and 95% confidence intervals.

Results
Nine studies involving 984,764 patients were included. The mean age of e-cigarette smokers was less than the controls, and female participants dominated the sample size. E-cigarette users were associated with increased odds of MI than non-users [OR = 1.44; 95% CI (1.22, 1.74); P < 0.0001]. Dual users were also associated with increased odds of MI with large effect when compared to non-users [OR = 4.04; 95% CI (3.40, 4.81); P < 0.00001].

Conclusions
Dual use is associated with an increased risk of MI than e-cigarette use only. Similarly, dual and solely e-cigarette consumption patterns of nicotine delivery are at a higher risk of MI than non-smokers.
Women’s visibility and bargaining power in the common bean value chain in Mozambique
Authors: Maereka Enock K. , Nchanji Eileen B. , Nyamolo Victor , Cosmas Lutomia K. , Chataika Bartholomew Y. 
Published: November 2023

AbstractWomen are involved in bean production and marketing, but their contribution is often invisible. This study is interested in understanding gender gaps in bean production, marketing, and decision-making powers over income and sales. A mixed method was used to collect survey data from 332 farming households and qualitative data from focus group discussions and key informant interviews. The respondents in the study were young men (30.42%), young women (13.25%), adult men (35.84%) and adult women (20.48%). From the results, adult men and young men owned more land than adult women and young women. Common bean had the highest median price of MZN25.00 (US$1.25) per kg over other crops such as maize at MZN7.00 (US$0.35), soybean at MZN 10 (US$0.50), groundnut at MZN 17 (US$0.85) and cowpea at MZN10.00 (US$0.50). The study revealed gender disparities in the control of bean sales and income. While there were no differences in the volume of bean grain sales between adult men and adult women, there were significant differences (p < 0.05) between young men and young women. Compared to young women, young men sold twice the bean grain volume and earned nearly twice more income, despite the two groups producing comparable volumes of bean grain. In conclusion, unlike the prevailing consensus that legumes are women’s crops, the economic benefits, particularly in common bean, accrue more to young men than to any other category in this study.
Experimental investigation on corroded and non-corroded RC tunnels under different loading conditions
Authors: Abdelaal Ahmed , Youssef Ahmed 
Published: November 2023

AbstractUnderground reinforced concrete (RC) structures, such as tunnels and pipelines, are frequently employed in urban areas and are designed to withstand both static and seismic loads, including those that occur during earthquakes. However, the inspection of deteriorated underground structures has yielded valuable findings for the civil engineering community, highlighting the need for further experimental investigation of the various damage mechanisms affecting RC tunnels under different loading conditions. This research presents a comprehensive experimental study aimed at elucidating the damage mechanisms of underground RC structures exposed to various loading conditions. Specifically, the study includes experimental testing of the corrosion of tunnel reinforcement and an investigation into the overall performance of corroded tunnels. The experimental results indicate that existing vertical loads significantly impact the lateral carrying capacity and ductility of RC tunnels.
Variables associated with admission rates among cancer patients presenting to emergency departments: a CONCERN group study
Authors: Rico Juan Felipe , Caterino Jeffrey M. , Stephens Julie A. , Abar Beau , Adler David , Bastani Aveh , Bernstein Steven L. , Bischof Jason J. , Coyne Christopher J. , Grudzen Corita R. , Henning Daniel J. , Hudson Matthew F. , Klotz Adam D. , Lyman Gary H. , Madsen Troy E. , Reyes Cielito C. , Ryan Richard J. , Shapiro Nathan I. , Swor Robert , Thomas Charles R. , Venkat Arvind , Wilson Jason , Yeung Sai-Ching Jim , Yilmaz Sule , Baugh Christopher W. 
Published: November 2023

Abstract
Background
Patients with cancer visit the emergency department often and have a high rate of admission compared to other patients. Admission rates by institution may vary widely, even after accounting for patient and hospital-specific characteristics.

Objectives
To review the variables that affect admission rates among patients with cancer in the emergency department.

Methods
We performed a secondary analysis of a prospective cohort study of patients with cancer at 18 emergency departments between March 1, 2016, and January 30, 2017, to examine differences in patient populations between hospitals with varying admission rates. We calculated the percentage admitted by hospital and used it to categorize hospitals into quartiles. We compared outcomes, patient demographics, and disease characteristics between the admission quartiles using linear or logistic regression.

Results
A total of 1075 patients were included. The median age of our sample was 64, and 51% of patients were female, 84% were white, and 13% were Black. Of the 1075 patients, 615 (57.2%) were admitted as inpatients with a range from 21.2 to 81.7% by hospital. Differences between admission quartiles were found for education, mode of arrival, and recent chemotherapy (p < 0.05). There were no significant differences among quartiles in age, gender, race, or ECOG score. We found significant difference between admission quartiles in 30-day emergency department revisits. Differences in readmission rates and mortality did not appear to be significant between the various quartiles.

Conclusions
In our study, we observed several differences among patients with cancer receiving care at hospitals with different admission rates. These included patients’ education level, mode of arrival, and whether they had received recent chemotherapy. Emergency Severity Index (ESI) score may have also contributed to admission rate variability. Further study into unmeasured factors influencing hospital admissions, such as local culture, resources, and pathways, could identify generalizable findings to reduce avoidable admissions and reduce variation among similar patients in different hospitals.
Smartphone-Based Passive Sensing in Monitoring Patients With Cancer: A Systematic Review
Authors: Stuijt Dominique G. , Radanovic Igor , Kos Milan , Schoones Jan W. , Stuurman Frederik E. , Exadaktylos Vasileios , Bins Adriaan D. , Bosch Jacobus J. , van Oijen Martijn G.H. 
Published: November 2023

PURPOSE Patients with cancer are prone to frequent unplanned hospital visits because of disease or treatment complications. Smartphone-based passive sensing (SBPS) comprises data collection using smartphone sensors or device usage patterns, which may be an affordable and burdenless technique for remote monitoring of patients with cancer and timely detection of safety events. The aim of this article was to systematically review the published literature to identify the current state of SBPS in oncology care and research. METHODS A literature search was done with cutoff date July 29, 2022, using six different databases. Articles were included if they reported original studies using SBPS in patients with cancer or cancer survivors. Data extracted from studies included type of sensors used, cancer type, study objectives, and main findings. RESULTS Twelve studies were included, the oldest report being from 2017. The most frequent of the nine analyzed sensors and smartphone analytics was the accelerometer (eight studies) and geolocation (eight studies), followed by call logs (two studies). Breast cancer was the most studied cancer type (eight studies with 111 patients), followed by GI cancers (six studies with 133 patients). All studies aiming for feasibility concluded that SBPS in oncology was feasible (seven studies). SBPS was used as a monitoring tool, with passively sensed data being correlated with adverse events, symptom burden, cancer-related fatigue, decision conflict, recovery trends after surgery, or psychosocial impact. SBPS was also used in one study as a predictive tool for health deterioration. CONCLUSION SBPS shows early promise in oncology, although it cannot yet replace traditional tools to monitor quality of life and clinical outcomes. For this, validation of SBPS will be required. Therefore, further research is warranted with this developing technique.
Intraoperative Laser Speckle Contrast Imaging to Assess Vessel Flow in Neurosurgery: A Pilot Study
Authors: Goldberg Johannes , Miller David R. , Dimanche Alexis , Kissling Cédric , Müller Timothy , Müller Mandy D. , Jesse Christopher Marvin , Murek Michael , Bervini David , Dunn Andrew K. , Raabe Andreas 
Published: November 2023

BACKGROUND AND OBJECTIVES:
Laser speckle contrast imaging (LSCI) has emerged as a promising tool for assessment of vessel flow during neurosurgery. We aimed to investigate the feasibility of visualizing vessel flow in the macrocirculation with a new fully microscope-integrated LSCI system and assess the validity and objectivity of findings compared with fluorescence angiography (FA).

METHODS:
This is a single-center prospective observational study enrolling adult patients requiring microsurgical treatment for brain vascular pathologies or brain tumors. Three independent raters, blinded toward findings of FA, reviewed regions of interest (ROIs) placed in exposed vessels and target structures. The primary end point was the validity of LSCI for assessment of vessel flow as measured by the agreement with FA. The secondary end point was objectivity, measured as the inter-rater agreement of LSCI findings.

RESULTS:
During 18 surgical procedures, 23 observations using FA and LSCI were captured simultaneously. Using LSCI, vessel flow was assessable in 62 (86.1%) and not assessable in 10 (13.9%) ROIs. The agreement between LSCI and FA was 86.1%, with an agreement coefficient of 0.85 (95% CI: 0.75-0.94). Disagreement between LSCI and FA was observed in the 10 ROIs that were not assessable. The agreement between ROIs that were assessable using LSCI and FA was 100%. The inter-rater agreement of LSCI findings was 87.9%, with an agreement coefficient of 0.86 (95% CI: 0.79-0.94).

CONCLUSION:
Fully microscope-integrated LSCI is feasible and has a high potential for clinical utility. Because of its characteristics, LSCI can be viewed as a full-field visual micro-Doppler that can be used as a complementary method to FA for assessing vessel flow during neurosurgery. Despite technical limitations related to the early development phase of the fully microscope-integrated system, we demonstrated reasonable validity and objectivity of findings compared with FA. Further research and refinement of the system may enhance its value in neurosurgical applications.
Tubb4b is required for multi-ciliogenesis in the mouse
Authors: Sewell Mycah T. , Legué Emilie , Liem Karel F. 
Published: November 2023

ABSTRACT
Cilia are microtubule (MT)-based organelles present on the surface of nearly all vertebrate cells. MTs are polymers of α- and β-tubulins that are each encoded by multiple, individual isotype genes. Tubulin isotype composition is thought to influence MT behaviors. Ciliary MTs differ from other MTs in the cell in terms of organization, stability and post-translational modifications. However, little is known about the tubulin isotypes that build ciliary MTs and the functional requirements for tubulin isotypes in cilia have not been examined in vertebrates. Here, we have tested the role of the β-tubulin isotype genes in the mouse that harbor a conserved amino acid motif associated with ciliated organisms. We found that Tubb4b localizes to cilia in multi-ciliated cells (MCCs) specifically. In respiratory and oviduct MCCs, Tubb4b is asymmetrically localized within multi-cilia, indicating that the tubulin isotype composition changes along the length of the ciliary axonemal MTs. Deletion of Tubb4b resulted in striking structural defects within the axonemes of multi-cilia, without affecting primary cilia. These studies show that Tubb4b is essential for the formation of a specific MT-based subcellular organelle and sheds light on the requirements of tubulin isotypes in cilia.
Improving the multi-functionality of optical tweezers with FPGA integration
Authors: Liu Shuo , Fan Xudong , Qu Zhelin , Fang Changfeng , Feng Chao , Zhao Xian , Wang Jun-Lei 
Published: November 2023

The development of optical tweezers aims to extend their operating function and pattern. However, excessive programming can lead to a decrease in the system’s operating speed and introduce bugs or data transmission delays. In this study, we present a time-shared optical tweezers system that allows for parallel operation of multiple functions. To enable efficient data transmission, we employ a queue structure and a buffer. To assess the system’s performance, we utilize a biological sample in conjunction with the optical tweezers system and scanning imaging technique. We quantify the trapping parameter while concurrently running power stabilization programs. As a result, the standard deviation of the measured stiffness is reduced by 60% in the x and y directions and 30% in the z direction, indicating a significant improvement in calibration precision. Throughout the program execution, the system maintains an operating rate of 110 kHz, and the data are continuously updated in real time on the host. The system’s performance demonstrates its potential for quantification and morphological reconstruction of biological samples.
Theoretical and experimental study on stable oscillation of dual-frequency signals in an optoelectronic oscillator
Authors: Chen Yuan , Fan Zhiqiang , Qiu Qi 
Published: November 2023

Due to the gain competition effect, it is hard to simultaneously maintain oscillation at two frequencies in an optoelectronic oscillator (OEO) loop. In this paper, a study of the gain competition effect in a dual-frequency OEO is theoretically and experimentally demonstrated. The steady-state conditions in the dual-frequency OEO are theoretically analyzed by deriving dynamic equations. A nonlinear time-varying model, as well as its calculation methods, is carried out to design and study the dynamic process of the dual-frequency OEO. Thanks to this model, the waveform, spectrum, and amplitude evaluation of generated signals, as well as the gain variation in the OEO loop, are numerically simulated. Based on the theoretical analysis and numerical simulation results, three schemes that can suppress the gain competition effect are proposed, and the one based on wavelength division multiplexing (WDM) technology is experimentally realized. The experimental results show that the novel independently tunable dual-frequency OEO, to the best of our knowledge, can generate two-tone RF signals in a range from 1.8 to 18.6 and 1.5 to 18.3 GHz, respectively.
Multi-field cosine condition in the design of wide-field freeform microscope objectives
Authors: Wang Menghui , Zhu Jun 
Published: November 2023

To break through the limitations of the classical sine condition, a multi-field cosine condition (MCC) is proposed in this paper. Building on this condition, a design method for wide field-of-view (FOV) freeform aplanatic systems is also proposed. This design method ensures that the optical system meets the MCC by correcting the mapping relationships of rays that originate from different apertures on both the object and image sides of the optical system. Using this method, we have successfully designed a chromatic-aberration-free and unobstructed freeform off-axis reflective microscope objective that is characterized by a wide FOV, an extensive spectral working range, and an extended working distance. The objective, which comprises only three freeform mirrors, has a numerical aperture (NA) of 0.4, magnification of 20×, an FOV of 2 mm × 2 mm, and an extended working distance of up to 60 mm. The objective demonstrates imaging quality close to the diffraction limit across the visible band to the short-wave infrared band (0.4–3 µm). When compared with a transmission-type wide-field microscope objective with identical NA and magnification properties, the reflective microscope objective nearly triples the FOV.
Effects of parental migration on early childhood development of left-behind children in Bangladesh: Evidence from a nationally representative survey
Authors: Khanam Shimlin Jahan , Khan Md Nuruzzaman 
Published: November 2023

Background
In Bangladesh, as in other low- and middle-income countries, parents frequently migrate to other areas, often for employment opportunities, leaving their children behind with the hope that their earnings will contribute to securing a better future for them. However, the absence of parents due to migration can have negative implications for the well-being of these left-behind children. Despite the existence of studies investigating this phenomenon, the evidence thus far has produced inconclusive findings, with no specific data available from Bangladesh. Therefore, the objective of this study was to examine the effects of parental migration on the early childhood development of left-behind children in Bangladesh.

Methods
The present study utilized data from the Bangladesh Multiple Indicator Cluster Survey (MICS) conducted in 2019. A sample of 8,833 children aged 3–4 years was included in the analysis. The Early Childhood Development Index (ECDI) and its individual domains served as the outcome variables of interest. The primary explanatory variables considered in the analysis were father migration, mother migration, migration of both parents, and migration of either parent. To assess the association between the outcomes and explanatory variables, multilevel logistic regression analysis was employed, controlling for relevant covariates.

Results
Approximately 29% of all children in the study were not developmentally on track, as measured by the ECDI. When examining the individual domains of the ECDI, only 9% of the total children demonstrated developmental progress in the learning domain. Regarding the association between parental migration and ECDI outcomes, we observed a 26% decrease in the likelihood of overall ECDI among children with a migrated father (OR: 0.74, 95% CI: 0.54–0.93). This decrease became even more pronounced, reaching 37% (OR: 0.63, 95% CI: 0.48–0.97), among children with both parents migrated, compared to children with neither parent migrated.

Conclusion
The findings of this study indicate that parental migration, especially when both parents are involved, has a substantial negative impact on the likelihood of achieving favourable ECDI outcomes for children in Bangladesh. To ensure the optimal development of children with migrating parents, it is crucial to strengthen early childhood development education programs and implement robust social safety nets. These efforts should specifically target the unique needs and challenges faced by children with migrated parents, providing them with the necessary support and resources for their holistic development.
Multidrug-resistant and carbapenemase-producing critical gram-negative bacteria isolated from the intensive care unit environment in Amhara region, Ethiopia
Authors: Kindu Mizan , Moges Feleke , Ashagrie Degu , Tigabu Zemene , Gelaw Baye 
Published: November 2023

Background
Intensive care units are units where healthcare-associated infections (HAIs) are common and antimicrobial resistance rates are increasing. Microbial contamination in hospital environment plays an important role in the development of HAIs. Intervention-based improvements in infection prevention and control at national and facility level are critical for the containment of antimicrobial resistance and prevention of HAIs.

Objectives
This study aimed to determine the distribution of multidrug-resistant and carbapenemase-producing critical gram negative bacteria (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Acinetobacter species) and their antibiotic resistance in intensive care unit environmental surfaces at the University of Gondar and Felege Hiwot Comprehensive Specialized Hospitals.

Methods
This was multicenter hospital-based cross sectional study. Environmental samples were swabbed from all intensive care units using a normal saline moistened-sterile cotton tip stick. Bacteria culturing and antibiotic susceptibility testing were performed following standard microbiological techniques. Selected meropenem-resistant isolates were phenotypically assessed for carbapenemase production using modified and simplified carbapenem inactivation methods.

Results
From a total of 384 environmental samples analyzed, 126 (32.8%) showed growth and 162 isolates were identified. K. pneumoniae (79/162, 48.8%) was the commonest isolate followed by Acinetobacter species (51/162, 31.5%), E. coli (19/162, 11.7%) and P. aeruginosa (13/162, 8.0%). Multidrug-resistant and carbapenemase-producing isolates were detected on most hospital environment surface types, especially from the baby bed sets and incubators. The most common multidrug-resistant and principal carbapenemase producer was K. pneumoniae, with rates of 71(89.9%) and 24(85.7%), respectively.

Conclusion
This study revealed the distribution of multidrug-resistant and carbapenemase-producing critical gram negative bacteria in the environment of intensive care unit. Higher detection rate of multidrug-resistant and carbapenemase-producing K. pneumoniae on most environmental surfaces calls for urgent control action and further attention.