bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weighing in on miniaturization: New body mass estimates for Triassic eucynodonts and analyses of body size evolution during the cynodont‐mammal transition
Authors: Kaiuca João Felipe Leal , Martinelli Agustín Guillermo , Schultz Cesar Leandro , Fonseca Pedro Henrique Morais , Tavares William Corrêa , Soares Marina Bento 
Published: January 2024

AbstractBody size influences most aspects of an animal's biology, consequently, evolutionary diversification is often accompanied by differentiation of body sizes within a lineage. It is accepted that miniaturization, or the evolution of extremely small body sizes, played a key role in the origin and early evolution of different mammalian characters in non‐mammaliaform cynodonts. However, while there are multiple studies on the biomechanical, behavioral, and physiological consequences of smaller sizes, few explore the evolutionary processes that lead to them. Here, we use body mass as a universal size measurement in phylogenetic comparative analyses to explore aspects of body size evolution in Cynodontia, focusing on the cynodont‐mammal transition, and test the miniaturization hypothesis for the origin of Mammaliaformes. We estimated the body masses of 29 species, ranging from Theriocephalia to Mammaliaformes, providing the largest collection of Triassic cynodont body mass estimates that we know of, and used these estimates in analyses of disparity through time and RRphylo. Unexpectedly, our results did not support the miniaturization hypothesis. Even though cynodont body size disparity fell during the Late Triassic, and remained lower than expected under a purely Brownian motion model of evolution up until the Early Jurassic, we found that rates of body size evolution were significantly lower in prozostrodontians leading to the first Mammaliaformes than in other lineages. Evolution rates were higher in medium and large‐sized taxa, indicating that size was changing more rapidly in those lineages and that small sizes were probably a persistent plesiomorphic character‐state in Cynodontia.
Potenzial direkter Materialuntersuchung im Bestand
Authors: Gebauer Daniel , Betz Peter , Fritsch Christina , Schacht Gregor , Marx Steffen 
Published: January 2024

AbstractDie wiederkehrende Fragestellung zur Wahl möglicher Grundgesamtheiten im Kontext von Materialuntersuchungen an Brückenüberbauten aus Stahl‐ und Spannbeton sowie den Festigkeitsreserven von Bestandsbeton werden in diesem Aufsatz für den spezifischen Fall einer Spannbetonbrücke mit abschnittsweiser Herstellung auf Vorschubrüstung untersucht. Hierfür wurden aus der im Rückbau befindlichen Talbrücke Unterrieden 141 Bohrkerne entnommen und auf Druck‐, Spaltzugfestigkeit oder Elastizitätsmodul hin geprüft. Die ermittelten Datensätze werden statistisch analysiert und zeigen eindrucksvoll das Potenzial der direkten Ermittlung von Materialkennwerten am Bestandsbauwerk. Insbesondere bei der mittleren Druckfestigkeit werden die Festigkeitsannahmen auf Basis von Bestandsunterlagen um bis zu 40 % übertroffen. Die aus Materialprüfung ermittelten Rechenwerte übersteigen die Annahmen auf Basis von Bestandsunterlagen sogar um über 100 %. Weiterhin erfolgt eine Untersuchung zu potenziellen Grundgesamtheiten am Überbau, um Empfehlungen für zukünftige Beprobungen zu erarbeiten. Hierzu wird die entnommene Stichprobe in verschiedene potenzielle Grundgesamtheiten unterteilt und statistisch analysiert. Im Ergebnis zeigt sich ein sehr gleichmäßiges Bauwerk mit einer Streuung deutlich unter den normativen Annahmen, welches kaum Argumente zu Unterteilung des Überbaus in verschiedene Grundgesamtheiten liefert.
Realization of digital twin for dynamic control toward sample variation of ion exchange chromatography in antibody separation
Authors: Shi Ce , Chen Xu‐Jun , Zhong Xue‐Zhao , Yang Yan , Lin Dong‐Qiang , Chen Ran 
Published: January 2024

AbstractDigital twin (DT) is a virtual and digital representation of physical objects or processes. In this paper, this concept is applied to dynamic control of the collection window in the ion exchange chromatography (IEC) toward sample variations. A possible structure of a feedforward model‐based control DT system was proposed. Initially, a precise IEC mechanistic model was established through experiments, model fitting, and validation. The average root mean square error (RMSE) of fitting and validation was 8.1% and 7.4%, respectively. Then a model‐based gradient optimization was performed, resulting in a 70.0% yield with a remarkable 11.2% increase. Subsequently, the DT was established by systematically integrating the model, chromatography system, online high‐performance liquid chromatography, and a server computer. The DT was validated under varying load conditions. The results demonstrated that the DT could offer an accurate control with acidic variants proportion and yield difference of less than 2% compared to the offline analysis. The embedding mechanistic model also showed a positive predictive performance with an average RMSE of 11.7% during the DT test under >10% sample variation. Practical scenario tests indicated that tightening the control target could further enhance the DT robustness, achieving over 98% success rate with an average yield of 72.7%. The results demonstrated that the constructed DT could accurately mimic real‐world situations and perform an automated and flexible pooling in IEC. Additionally, a detailed methodology for applying DT was summarized.
Word‐of‐mouth innovation: A product development shortcut for organic skin care entrepreneurs in Thailand?
Authors: Vittayavarakorn Narit , Sornsaruht Puris 
Published: January 2024

AbstractThis study explores the impact of perceived quality, brand attitude, consumer satisfaction, and the marketing mix on word‐of‐mouth innovation (WOMI) in the organic skincare industry in Thailand. Systematic random sampling was used in 2023 to select 453 organic skincare users whose questionnaire was expert‐validated and tested. Investigating these interconnected factors, the research contributes to consumer behavior and innovation theories. It reveals crucial links, notably between brand attitude and perceived quality, expanding theoretical frameworks. Beyond theoretical advancements, the study provides actionable insights for entrepreneurs, marketers, and policymakers. Recognizing the pivotal role of consumer reviews in driving WOMI, industry stakeholders can enhance product quality, tailor marketing strategies, and foster innovation. Bridging theory and practice, this research empowers stakeholders to make informed decisions, adapt strategies, and contribute to the growth of the organic skincare sector. In conclusion, the study enhances theoretical understanding while offering practical implications, fostering a symbiotic relationship between academic knowledge and industry advancements.
Identifying determinants of adherence to adjuvant endocrine therapy following breast cancer: A systematic review of reviews
Authors: Todd Adam , Waldron Catherine , McGeagh Lucy , Norris Ruth , Bolnykh Iakov , Stewart Sarah Jane , Slodkowska‐Barabasz Joanna , Moon Zoe , Cahir Caitriona , Thompson Sue , Harmer Victoria , Wells Mary , Watson Eila , Sharp Linda ,   the SWEET Research Team
Published: January 2024

AbstractBackgroundIn oestrogen‐receptor positive breast cancer, daily oral adjuvant endocrine therapy (ET) for at least 5 years significantly reduces risks of recurrence and breast cancer‐specific mortality. However, many women are poorly adherent to ET. Development of effective adherence support requires comprehensive understanding of influences on adherence. We undertook an umbrella review to identify determinants of ET adherence.MethodsWe searched PubMed, Embase, CINAHL, PsycINFO, Cochrane and PROSPERO (inception to 08/2022) to identify systematic reviews on factors influencing ET adherence. Abstracted determinants were mapped to the World Health Organization's dimensions of adherence. Reviews were quality appraised and overlap assessed.ResultsOf 5732 citations screened, 17 reviews were eligible (9 quantitative primary studies; 4 qualitative primary studies; 4 qualitative or quantitative studies) including 215 primary papers. All five WHO dimensions influenced ET non‐adherence: The most consistently identified non‐adherence determinants were patient‐related factors (e.g. lower perceived ET necessity, more treatment concerns, perceptions of ET ‘cons’ vs. ‘pros’). Healthcare system/healthcare professional‐related factors (e.g. perceived lower quality health professional interaction/relationship) were also important and, to a somewhat lesser extent, socio‐economic factors (e.g. lower levels of social/economic/material support). Evidence was more mixed for medication‐related and condition‐related factors, but several may be relevant (e.g. experiencing side‐effects, cost). Potentially modifiable factors are more influential than non‐modifiable/fixed factors (e.g. patient characteristics).ConclusionsThe evidence‐base on ET adherence determinants is extensive. Future empirical studies should focus on less well‐researched areas and settings. The determinants themselves are numerous and complex in indicating that adherence support should be multifaceted, addressing multiple determinants.
Transcriptomics Analysis of the Immune Effects of Okadaic Acid on Caco‐2 Cells
Authors: Xu Ruihang , Wang Li , He Peimin , Jia Rui 
Published: January 2024

AbstractOkadaic Acid, a type of diarrhetic shellfish poison, is widely distributed and harmful, causing symptoms such as diarrhea, vomiting, and more in humans. Recent studies have demonstrated that OA can lead to various toxicities such as cytotoxicity, neurotoxicity, embryotoxicity, and hepatotoxicity. In order to investigate the immunotoxicity of OA on intestinal cells, a transcriptome analysis was conducted to compare the differences in the Caco‐2 cell transcriptional group before and after administration. The CCK‐8 experiment demonstrated that OA had a detrimental effect on the activity of Caco‐2 cells, with an IC50 value of 33.98 nM. Transcriptome data revealed changes in immune‐related genes between the experimental and control groups, including inflammatory factors, heat shock proteins, and zinc finger proteins. The analysis of the results suggests that OA can induce the production of inflammatory factors and apoptosis in cells, and may also affect cell ferroptosis. These findings indicate that OA has a significant impact on intestinal immunity, providing valuable insights for the study of immune toxicity associated with OA.
Amplifying T cell‐mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti‐PD1
Authors: Gong Beilei , Wang Liping , Zhang Han , Wang Qingkai , Li Wei 
Published: January 2024

AbstractPhotodynamic therapy (PDT) is nowadays widely employed in cancer treatment. We sought to assess the efficacy of combining PDT with anti‐programmed cell death protein 1 (PD1) and to investigate the associated mechanisms in nonsmall cell lung cancer (NSCLC). We established a xenograft tumor model in C57BL/6J mice using Lewis lung carcinoma (LLC) cells, recorded tumor growth, and quantified reactive oxygen species (ROS) levels using a ROS detection kit. Pathological changes were assessed through H&E staining, while immunofluorescence (IF) was used to determine the expression of CD8 and Foxp3. Transcriptomic analysis was conducted, analyzing differential expressed genes (DEGs) among control, PDT, and PDT combined with anti‐PD1 (PDT+anti‐PD1) groups. Functional enrichment analysis via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) was performed. The Cancer Genome Atlas (TCGA) database was utilized to analyze the expression of aminolevulinate synthase gene (ALAS2), integrin alpha10 (ITGA10), ATP1A2, a disintegrin and metalloprotease 12 (ADAM12), and Lox1 in lung adenocarcinoma and adjacent tissues, with concurrent immune infiltration analysis. Quantitative real‐time polymerase chain reaction and western blot were employed to measure mRNA and protein expression levels. Treatment with PDT combined with anti‐PD1 significantly inhibited tumor growth and increased the number of CD8+ cells while decreasing Foxp3+ cells. Immune infiltration results presented ALAS2, ADAM12, and ITGA10 were associated with various types of T cells or macrophages. Additionally, the expression levels of EGFR, ERK, and PI3K/Akt were suppressed after PDT with anti‐PD1 treatment. Our findings collectively suggest that PDT combined with anti‐PD1 treatment could enhance the infiltration of CD8+ T cells, suppressing tumor growth, and this effect was associated with ALAS2, ITGA10, and ADAM12. The underlying mechanism might be linked to EGFR, ERK, and PI3K/Akt signaling. Overall, this study provides valuable insights into the application of PDT combined with anti‐PD1 treatment in NSCLC.
Design of Multi‐Luminescent Silica‐Based Nanoparticles for the Detection of Liquid Organic Compounds
Authors: Delic Asmira , Lindgren Mikael , Psarrou Maria , Economopoulos Solon , Mariussen Espen , Krivokapic Alexander , Torsæter Ole , Omran Mohamed , Einarsrud Mari‐Ann 
Published: January 2024

AbstractTracer testing in reservoir formations is utilised to determine residual oil saturation as part of optimum hydrocarbon production. Here, we present a novel detection method of liquid organic compounds by monodisperse SiO2 nanoparticles (NPs) containing two luminophores, a EuIII:EDTA complex and a newly synthesised fluorophore based on the organic boron‐dipyrromethene (BODIPY)‐moiety. The particles exhibited stable EuIII PL emission intensity with a long lifetime in aqueous dispersion. The fluorescence of the BODIPY was also preserved in the aqueous environment. The ratiometric PL detection technique was demonstrated by using toluene and 1‐octanol as model compounds of crude oil. The optimal synthesis conditions were found to give NPs with a diameter of ~100 nm, which is suitable for transport through porous oil reservoir structures. The cytotoxicity of the NPs was confirmed to be very low for human lung cell and fish cell lines. These findings demonstrate the potential of the NPs to replace the hazardous chemicals used to estimate the residual oil saturation. Moreover, the ratiometric PL detection technique is anticipated to be of benefit in other fields, such as biotechnology, medical diagnostics, and environmental monitoring, where a reliable and safe detection of a liquid organic phase is needed.
Synthesis and Isolation of a Homochiral Nanohoop Composed of a Tröger's Base and Hexaparaphenylene
Authors: Yoshigoe Yusuke , Shimada Hirotaka , Takaki Takuya , Imai Yoshitane , Saito Shinich 
Published: January 2024

AbstractThe synthesis of a new nanohoop containing a stereogenic Tröger's base skeleton tethered to a curved hexaparaphenylene ([6]CPP) is reported. The TB[6]CPP nanohoop possesses a stable C2 symmetrical structure, which promotes the allowed transition that gives rise to pale blue emission with a quantum yield of ~0.69, surpassing the value of the more symmetrical [8]CPP. Moreover, TB[6]CPP shows chiroptical properties including circular dichroism and circularly polarized luminescence with a moderate dissymmetry factor (|glum|) of ~2.1×10−3
Noble‐Metal‐Free Carbon Encapsulated CoNi Alloy Catalyst for the Hydrogenation of 5‐(Hydroxymethyl) Furfural to Tetrahydrofurandiol in Aqueous Media
Authors: Arias Karen S. , Hurtado Beatriz , Climent Maria J. , Iborra Sara , Corma Avelino 
Published: January 2024

AbstractThe selective hydrogenation of 5‐(hydroxymethyl)furfural (HMF) into 2,5‐bis‐(hydroxymethyl)tetrahydrofuran (BHMTHF) in flow reactor using water as a green solvent, has been achieved on a non‐noble metal catalyst based on monodispersed CoNi alloy nanoparticles covered by a thin carbon layer. The alloyed catalyst containing CoNi (molar ratio 1 : 1) was prepared in a one‐step synthesis following a hydrothermal method. Total conversion of HMF with 91 % selectivity to BHMTHF was achieved. The reaction network has been stablished, in which the carbonyl group of HMF is first reduced to alcohol giving the 2,5‐bis‐(hydroxymethyl)furan (BHMF) with an apparent activation energy of 25 KJ/mol, and then the double bonds of the furan ring are hydrogenated (apparent Ea=31 KJ/mol). Formation of byproducts, mainly proceed from furan ring opening and ring rearrangement processes of BHMF, promoted by water. BHMTHF resulted a compound highly stable under reaction conditions. The fixed bed flow reactor was maintained operational for 65 h without observing any loss of catalytic activity and selectivity.
A new floating memcapacitor emulator circuit without using passive elements
Authors: Korkmaz Muhammet Oguz , Babacan Yunus , Yesil Abdullah 
Published: January 2024

SummaryIn this paper, a new floating memcapacitor emulator that consists of a single multiplier and only four transistors without using passive elements is proposed. While two of these transistors work as MOS capacitors, two of them are used to provide transconductance gain. Moreover, the proposed memcapacitor operates at high frequencies thanks to having simple structures. Furthermore, fix and variable parts of memcapacitance can be tuned electronically by changing DC bias voltages. In order to investigate the performance of the proposed memcapacitor, simulation results are given for different operating frequencies, radical temperature changes, memory effects, and Monte Carlo analysis. Moreover, to confirm the practical realization of the proposed memcapacitor, the proposed floating memcapacitor is implemented by using commercial devices as AD633, ALD1106, and ALD1107. Experimental results of the proposed circuit are given for different operating frequencies and DC supply voltages. Also, a memcapacitor‐based circuit that emulates the relationship between the amoeba's locomotive speed and temperature is given as an application of the proposed memcapacitor. The results for the proposed memcapacitor are in good agreement with theoretical data.
Reconstruction of synthetic aperture radar data using hybrid compressive sensing and deep neural network algorithm
Authors: Paramasivam Saranya , Kaliyaperumal Vani 
Published: January 2024

SummaryThe reconstruction of reflectivity profile of the synthetic aperture radar (SAR) is an important field of research. SAR tomography is an advanced 3D imaging technique for the spectrum estimation in the elevation direction for each azimuth resolution cell. This work presents the processing chain for the tomographic reconstruction from ALOS PALSAR data for an urban region. First, the data are preprocessed by removing the speckle noise followed by atmospheric phase screen and topographic correction. Then the SAR images are stacked together with one master image and the remaining slave images on the baseline value. After the images are coregistered, the interferogram is generated from the image to obtain the difference of the phase value. Then the proposed super resolution SAR (SRS) algorithm is attempted for TomoSAR processing, which combines the functionality of modern machine learning method like deep learning with parametric block‐based compressive sensing approach. Finally, a 3D image is reconstructed from the input data. Evaluation is carried out by comparing the results of the proposed method with other spectrum estimation methods such as nonlinear least square, Capon, and multisignal classification. The normal baseline of the interferometric fringes is about 368.54 m. The proposed SRS algorithm gives improved results with less mean elevation error of 1.8 m and the less standard deviation error of 4.85 m. Finally, the result reveals that the SRS algorithm performed better than other TomoSAR algorithms with the less relative error 0.003.
Costunolide attenuates high‐fat diet‐induced inflammation and oxidative stress in non‐alcoholic fatty liver disease
Authors: Wang Jiong , Jin Bo , Chen Yanghao , Chen Yi , Zuo Wei , Huang Lijiang , Lin Jianjun , Jiang Yongsheng , Xie Longteng , Lian Xiang , Wang Yi 
Published: January 2024

AbstractNon‐alcoholic fatty liver disease (NAFLD) is a progressive disease that can further evolve towards liver fibrosis and hepatocellular carcinoma in the end stage. Costunolide (Cos) is a natural sesquiterpene lactone that exhibits both anti‐inflammatory and antioxidant properties. However, the therapeutic effect of Cos on NAFLD is not clear. In this study, we explored the potential protective effect and mechanism of Cos on NAFLD. C57BL/6 mice were fed with high‐fat diet (HFD) to induce NAFLD. Cos was administered by gavage to observe the effect of Cos on NAFLD. We demonstrated that oral administration of Cos reduced HFD‐induced hepatic fibrosis and the release of inflammatory cytokines, limiting the generation of reactive oxygen species. In vitro experiments revealed that pretreatment with Cos significantly decreased PA‐induced production of inflammatory cytokines and fibrosis in AML‐12 cells. Mechanism study showed that the effect of Cos was correlated to the induction of Nrf‐2 and inhibition of NF‐κB pathways. Collectively, these findings indicated that Cos exerts hepatoprotective effect against NAFLD through blocking inflammation and oxidative stress. Our study suggested that Cos might be an effective pharmacotherapy for the treatment of NAFLD.
Comparison of surgical outcomes of transoral robotic and endoscopic thyroidectomy: A systematic review and network meta‐analysis
Authors: Nguyen Van Cuong , Song Chang Myeon , Ji Yong Bae , Oh Sukjoong , Jeong Jin Hyeok , Tae Kyung 
Published: January 2024

AbstractThis study aimed to compare surgical outcomes of transoral robotic thyroidectomy (TORT) and transoral endoscopic thyroidectomy vestibular approach (TOETVA), concurrently compared with conventional transcervical thyroidectomy (CTT). A network meta‐analysis, comprising 23 studies, was performed in this study. The operative time of the CTT group was significantly shorter than that of the TOETVA and TORT groups. The hospital stay of the TOETVA group was significantly longer than that of the CTT group. Rates of transient recurrent laryngeal nerve palsy and total complications were higher in association with TOETVA than with TORT. No significant differences were found between the three groups in intraoperative blood loss, retrieved lymph nodes, postoperative pain, and other complications. Cosmetic satisfaction was significantly superior with TORT and TOETVA than with CTT. Compared with CTT, TOETVA and TORT showed superior cosmesis but no significant difference in surgical outcomes except for operative time and hospital stay.