bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sur la date de la création de l'alphabet grec
Authors:   Ruijgh
Published: August 2004

Abstract§1. Introduction. L'absence d'inscriptions retrouvées ne prouve pas l'absence de l'écriture. — §2. L'emploi primaire de l'alphabet grec était celui de la comptabilité. Le créateur était un Ionien d'Eubée. — §3. Les emplois secondaires de l'écriture alphabétique. — §4. Le choix du ḥet pour le h- grec prouve que lors de la création, le h- grec était encore une consonne relativement forte, c.-à-d. que la création date d'env. 1000. L'argumentation de Slings ne tient pas bon. — §5. Les valeurs grecques des lettres phéniciennes dans l'ordre de l'abécédaire. — §6. Les lettres additionnelles. La suppression de lettres devenues surperflues. — §7. La forme originelle du σάν < *tsan. L'emploi du σαμ(Πει) en Ionie et en Pamphylie. — §8. Les arguments décisifs contre l'hypothèse de Slings, qui voit dans le σαμ(Πει) une lettre additionnelle. — §9. La suppression du σαμ(Πει) dans l'abécédaire de Milet, la création du système numéral milésien vers 700 et l'abécédaire de Samos. — §10. L'emploi du fαυ dans le monde ionien-attique de l'époque archaïque. Les noms δίγαμμα et σαμΠει. — §11. L'emploi du σάν pour exprimer s dans les régions de la Crète et de Corinthe. L'emploi ultérieur du nom σάν. — §12. L'emploi crétois et achaïen du ζητα pour -ts- conservé à l'époque archaïque. — §13. L'emploi du σάν pour ts- < kw- (devant voyelle palatale) en Arcadie. — §14. Récapitulation: la date env. 1000 de la création de l'alphabet grec, à laquelle invite le choix du ḥet pour le h- grec, permet une explication cohérente des divers emplois locaux du *tsan > σάν. — §15. Le h- faible de l'eubéen du VIIIe s. (coupe de Pithécuses). L'emploi naxien de la graphie -hs- pour l'aboutissement de -khs-. — §16. La genèse de l'ionien épique d'Homère: ionien oriental avec un vernis eubéen. — §17. L'histoire de s initial et intervocalique en proto-grec; la création de la géminée ss pour s+s en grec septentrional. — §18. La première vague de changements: ts > s, ty > s, ti > si; la différenciation dialectale. — §19. La seconde vague de changements: ty > ts, dy > dz, tw > ts. Les changements ultérieurs du Ier millénaire. — §20. Conclusion.
Increased contractile responses to 5-hydroxytryptamine and Angiotensin II in high fat diet fed rat thoracic aorta
Authors: Ghatta Srinivas , Ramarao Poduri 
Published: August 2004

Abstract
Background
Feeding normal rats with high dietary levels of saturated fat leads to pathological conditions, which are quite similar to syndrome X in humans. These conditions such as hypertriglyceridemia, hypercholesterolemia, obesity, and hyperglycemia might induce hypertension through various mechanisms. Metabolic syndrome and the resulting NIDDM represent a major clinical challenge because implementation of treatment strategies is difficult. Vascular abnormalities probably contribute to the etiology of many diabetic complications including nephropathy, neuropathy, retinopathy, and cardiomyopathy. It has been shown that in Streptozotocin induced diabetic animals there is an increase in maximal responses to 5-Hydroxytryptamine and Angiotensin II. The purpose of this study was to evaluate High fat diet fed rats for the development of hypertriglyceridemia, hypercholesterolemia, hyperinsulinemia and hyperglycemia and to assess their vascular responses to 5-Hydroxytryptamine and Angiotensin II.

Methods
Male Sprague Dawley rats were used for this study and were divided into two equal groups. One of the groups was fed with normal pellet diet and they served as the control group, whereas the other group was on a high fat diet for 4 weeks. Body weight, plasma triglycerides, plasma cholesterol, and plasma glucose were measured every week. Intraperitoneal glucose tolerance test was performed after 4 weeks of feeding. At the end of fourth week of high fat diet feeding, thoracic aortae were removed, and cut into helical strips for vascular reactivity studies. Dose-response curves of 5-Hydroxytryptamine and Angiotensin II were obtained.

Results
There was no significant difference in pD2, with 5-Hydroxytryptamine and Angiotensin II in both groups but Emax was increased.

Conclusions
These results suggest that hypertension in high fat diet rats is associated with increased in vitro vascular reactivity to 5-HT and Ang II.
Estimating age conditional probability of developing disease from surveillance data
Authors: Fay Michael P 
Published: August 2004

AbstractFay, Pfeiffer, Cronin, Le, and Feuer (Statistics in Medicine 2003; 22; 1837–1848) developed a formula to calculate the age-conditional probability of developing a disease for the first time (ACPDvD) for a hypothetical cohort. The novelty of the formula of Fay et al (2003) is that one need not know the rates of first incidence of disease per person-years alive and disease-free, but may input the rates of first incidence per person-years alive only. Similarly the formula uses rates of death from disease and death from other causes per person-years alive. The rates per person-years alive are much easier to estimate than per person-years alive and disease-free. Fay et al (2003) used simple piecewise constant models for all three rate functions which have constant rates within each age group. In this paper, we detail a method for estimating rate functions which does not have jumps at the beginning of age groupings, and need not be constant within age groupings. We call this method the mid-age group joinpoint (MAJ) model for the rates. The drawback of the MAJ model is that numerical integration must be used to estimate the resulting ACPDvD. To increase computational speed, we offer a piecewise approximation to the MAJ model, which we call the piecewise mid-age group joinpoint (PMAJ) model. The PMAJ model for the rates input into the formula for ACPDvD described in Fay et al (2003) is the current method used in the freely available DevCan software made available by the National Cancer Institute.
Prozessidentifikations-basierter Entwurf beobachtergestützter Fehlerdetektionssysteme (System Identification Aided Design of Observer-based Fault Detection Systems)
Authors: Ding Steven X. , Zhang Ping , Heyden Dirk , Huang Biao , Ding Eve L. 
Published: July 2004

AbstractDer vorliegende Beitrag befasst sich mit der beobachtergestützten Fehlerentdeckung. Es wird ein Verfahren vorgestellt, das es ermöglicht, einen beobachtergestützten Residuengenerator direkt aus Prozessmess- oder Testdaten zu entwerfen. Die Grundidee dieses Verfahrens besteht darin, die Identifikation eines auf Fehlerdetektion gerichteten Prozessmodells in den Entwurf des beobachtergestützten Residuengenerators zu integrieren.
Maschinenintegrierte Ultrapräzisionsmessung optischer Funktionsflächen (Machine-integrated Ultra Precision Measurement of Functional Optical Surfaces)
Authors: Dörner Dirk , Schneefuß Karsten 
Published: July 2004

Abstract
Die Qualitätsprüfung von optischen Bauteilen, Werkzeugformen für Spritzguss- oder Blankpressprozesse oder mikrostrukturierten Oberflächen wird derzeit meist in Stichproben unter Laborbedingungen fernab des Produktionsprozesses durchgeführt. Eine Nacharbeit oder örtlich begrenzte Korrekturen zur Optimierung der Produkte gestalten sich schwierig, weil das Bauteil erneut der Bearbeitung zugeführt werden muss. Dabei ist die genaue Rekonstruktion von Ort und Lage der messtechnisch bestimmten Abweichungen mit den geforderten Genauigkeiten in der Maschine meistens nicht möglich. Daher werden am Fraunhofer IPT ultrapräzise Messverfahren direkt in die Bearbeitungsmaschine integriert.
Neues optoelektronisches Inkrementalsystem zur Anwendung bei Magnetlagern (New Opto-electronic Incremental System for Implementation in Magnetic Bearings)
Authors: Molitor Martin , Stockmann Veit 
Published: July 2004

Abstract
Für den Einsatz im Maschinenbau wurde ein magnetschwebetechnisches Fertigungssystem auf der Basis des TransRapid entwickelt. Durch das Freischweben des Rotors im Raum sind berührend arbeitende Messeinrichtungen für die hochgenaue Drehwinkelerfassung nicht verwendbar. Da alle Bewegungsgrade frei sind, konnte nur ein berührungsloses Messsystem zum Einsatz kommen. Dieses System muss ein erhebliches Spiel der Apparatur über den Luftspalt hinweg mit einbeziehen und trotzdem genaue Werte liefern. Hierzu wurde eine neuartige Technik zum Bestimmen der Drehwinkelposition entwickelt. Es handelt sich hierbei um eine inkrementale Messeinrichtung mit Trapezen als Inkremente, die im Durchlichtverfahren abgetastet werden. Die praktischen Untersuchungen zu dem Messverfahren erfolgten auf zwei Arten. Zum einen wurde ein Laser-Scanner zum Nachweis der zu erzielenden Messunsicherheit benutzt. Zum anderen kam zur Simulation der erreichbaren Messgeschwindigkeit eine Matrixkamera zum Einsatz. Auf der Basis dieser Ergebnisse soll nun eine praktische Umsetzungsform zur Anwendung bei magnetgelagerten Baugruppen im Fertigungsmittelbau entwickelt werden.
Selbstausrichtender Messroboter für Sichtprüfaufgaben im Nahbereich (Self-Aligning Measuring Robot for Visual Close-Range Inspections)
Authors: Mönning Frank 
Published: July 2004

Abstract
Zur Prozessregelung und Qualitätssicherung werden insbesondere in der Karosseriefertigung in zunehmendem Maße robotergestützte Inline-Messsysteme eingesetzt. Mit diesen Anlagen ist die Realisierung neuer Prüfkonzepte wie der 100%-Prüfung möglich. Im vorliegenden Beitrag wird ein System vorgestellt, mit dem robotergestützte Messprozesse effizienter programmiert werden können.
Al₂O₃‐Functionalized Carbon Nanomembranes with Enhanced Water Permeance and Selectivity for Efficient Air Dehumidification
Authors: Biedinger Jan , Yao Zhen , Wortmann Martin , Westphal Michael , Frese Natalie , Gehra Raphael , Brandt Niklas , Kaltschmidt Bernhard Peter , Hütten Andreas , Gölzhäuser Armin , Reiss Günter 
Published: February 2025

AbstractPrecise control of pore size and surface properties is crucial for effective and efficient membrane separation, yet it remains challenging with conventional polymer‐based membranes. In this study, this gap is addressed by integrating atomic layer deposition (ALD) of Al2O3 with nanometer‐thin carbon nanomembranes (CNMs) to achieve ultra‐selective separation properties. Structural characterizations confirm uniform Al2O3 deposition and the preservation of the CNM structure. The ALD process allows for precise modulation of the nanopore structure. Despite the pore shrinkage upon ALD, the increased hydrophilicity offered by Al2O3 enhances water permeance, achieving an exceptionally high water vapor permeation rate of 1.9  ×  10−5 mol · s−1 · m−2 · Pa−1 and a water vapor/nitrogen selectivity higher than 1  ×  104, surpassing that of conventional polymer and graphene oxide‐based membranes. These results demonstrate the potential of Al2O3‐functionalized CNMs for advanced applications in gas separation and air dehumidification.
Intermediate Layer‐Assisted Trap Density Reduction in Low‐Power Optoelectronic Memristors for Multifunctional Systems
Authors: Lee Min Jong , Kim Tae Hyuk , Lee Sang Heon , Oh Seunghyun , Khan Muhammad Asghar , Lee Gyeong Min , Choi Young Kyun , Lee Soyeon , Ahn Hyungju , Oh Soong Ju , Yang Jiwoong , Shim Jae Won 
Published: February 2025

AbstractThe rapid expansion of the Internet of Things demands low‐power devices that integrate memory, sensors, and logic functions. Perovskite materials show promise for low‐power optoelectronic memristors; however, challenges such as nonuniform trap distribution and uncontrolled filament formation hinder their resistive switching performance. To overcome these issues, a TiO2 nanofilm via atomic layer deposition as a base layer for filament formation, is introduced. This layer passivates interfacial defects by forming strong chemical interactions with Pb2+ and I− ions at the perovskite interface, significantly reducing trap densities (interface trap density decreases 15‐fold to 3.0 × 1016 cm−3, and bulk trap density to 1.8 × 1014 cm−3). Improved energy band alignment enables efficient electron transport, yielding a low‐V
SET (+0.24 V) and excellent low‐power (≈0.7 µW) nonvolatile memory performance. Additionally, the device reliably detects near‐infrared illumination as an optical input and enables reconfigurable image recognition using a 5 × 5 array under combined stimuli. It also facilitates the implementation of complex logic gates, such as AND, OR, and flip‐flops. This paper demonstrates the potential for integrating nonvolatile memory, sensing, and logic functionalities into a single low‐power device through the incorporation of a TiO2 nanolayer.
Enhanced Antigen Capture via Cholinephosphate‐Mediated Cell Membrane Interactions to Improve In Situ Tumor Vaccines
Authors: Song Ting , Cui Xin , Lin Jiansheng , Liu Zonghua , Huang Linghong , Xue Wei 
Published: February 2025

AbstractInadequate antigen capture and insufficient antigen‐presenting cell (APC) activity at tumor sites limit the effectiveness of in situ vaccines. To address this, poly(glutamic acid‐cholinephosphate) (pGluCP) is introduced as a polymer with cell membrane adhesion properties capable of capturing both water‐soluble and insoluble membrane antigens from necrotic tumor cells while recruiting more APCs. The approach uses manganese‐mineralized black phosphorus (MnBP) coated with pGluCP and αPD‐1 antibodies to create the MnBP@pGluCP‐αPD‐1 complex for in situ vaccines. MnBP eradicates tumor cells via photothermal effects, releasing antigens, while Mn2⁺ ions activate the intracellular STING pathway, acting as an adjuvant. pGluCP captures these antigens, forming pathogen‐mimicking micro‐nanoparticles, leading to an in situ vaccine (MnBP@pGluCP/antigens) that co‐localizes antigens and adjuvants. The αPD‐1 antibody alleviates tumor‐induced immune suppression, enhancing tumor cell‐specific killing. This study demonstrates the potential of leveraging cholinephosphate‐cell membrane interactions to improve antigen presentation efficiency, significantly bolstering the efficacy of in situ tumor vaccines and opening new avenues for advanced cancer immunotherapy.
Bioinspired Super‐Robust Conductive Hydrogels for Machine Learning‐Assisted Tactile Perception System
Authors: Xue Chao , Zhao Yanran , Liao Yuantai , Zhang Hongyu 
Published: February 2025

AbstractConductive hydrogels have attracted significant attention due to exceptional flexibility, electrochemical property, and biocompatibility. However, the low mechanical strength can compromise their stability under high stress, making the material susceptible to fracture in complex or harsh environments. Achieving a balance between conductivity and mechanical robustness remains a critical challenge. In this study, super‐robust conductive hydrogels were designed and developed with highly oriented structures and densified networks, by employing techniques such as stretch‐drying‐induced directional assembly, salting‐out, and ionic crosslinking. The hydrogels showed remarkable mechanical property (tensile strength: 17.13–142.1 MPa; toughness: 50 MJ m−3), high conductivity (30.1 S m−1), and reliable strain sensing performance. Additionally, it applied this hydrogel material to fabricate biomimetic electronic skin device, significantly improving signal quality and device stability. By integrating the device with 1D convolutional neural network algorithm, it further developed a real‐time material recognition system based on triboelectric and piezoresistive signal collection, achieving a classification accuracy of up to 99.79% across eight materials. This study predicted the potential of the high‐performance conductive hydrogels for various applications in flexible smart wearables, the Internet of Things, bioelectronics, and bionic robotics.
Supramolecular Engineering of Vinylene‐Linked Covalent Organic Framework – Ruthenium Oxide Hybrids for Highly Active Proton Exchange Membrane Water Electrolysis
Authors: Wang Kexin , Xu Shunqi , Wang Dashuai , Kou Zhenhui , Fu Yubin , Bielejewski Michał , Montes‐García Verónica , Han Bin , Ciesielski Artur , Hou Yang , Samorì Paolo 
Published: February 2025

AbstractThe controlled formation of a functional adlayer at the catalyst‐water interface is a highly challenging yet potentially powerful strategy to accelerate proton transfer and deprotonation for ultimately improving the performance of proton‐exchange membrane water electrolysis (PEMWE). In this study, the synthesis of robust vinylene‐linked covalent organic frameworks (COFs) possessing high proton conductivities is reported, which are subsequently hybridized with ruthenium dioxide yielding high‐performance anodic catalysts for the acidic oxygen evolution reaction (OER). In situ spectroscopic measurements corroborated by theoretical calculations reveal that the assembled hydrogen bonds formed between COFs and adsorbed oxo‐intermediates effectively orient interfacial water molecules, stabilizing the transition states for intermediate formation of OER. This determines a decrease in the energy barriers of proton transfer and deprotonation, resulting in exceptional acidic OER performance. When integrated into a PEMWE device, the system achieves a record current density of 1.0 A cm−2 at only 1.54 V cell voltage, with a long‐term stability exceeding 180 h at industrial‐level 200 mA cm−2. The approach relying on the self‐assembly of an oriented hydrogen‐bonded adlayer highlights the disruptive potential of COFs with customizable structures and multifunctional sites for advancing PEMWE technologies.
Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel
Authors: Wu Wen , Zhang Jian , Qu Xiao , Chen Ting , Li Jinming , Yang Yongzhi , Chen Lifeng , Hoover Alex , Guo Fanying , Kong Cheng , Bao Bingkun , Lin Qiuning , Zhou Mengxin , Zhu Linyong , Wu Xiaoyang , Ma Yanlei 
Published: February 2025

AbstractUlcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non‐specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery of a synthetic hydrogel material with biocompatible gelation that can efficiently cover irregular tissue surfaces provides an effective approach for targeted drug delivery at the gastrointestinal (GI) tract. An ideal integration of synthetic material with intestinal epithelium entails an integrated and preferable chemically bonded interface between the hydrogel and mucosal surface. In this study, a photo‐triggered coupling reaction is leveraged as the crosslinking platform to develop a mucosal‐adhesive hydrogel, which is compatible with endoscope‐directed drug delivery for UC treatment. The results demonstrated superior spatiotemporal specificity and drug pharmacokinetics with this delivery system in vivo. Delivery of different drugs with the hydrogel leads to greatly enhanced therapeutic efficacy and significantly reduced systemic drug exposure with rat colitis models. The study presents a strategy for targeted and persistent drug delivery for UC treatment.
Synthesis of Highly Functionalized Tetrahydropyridines by Ring Opening of [3.3.1]‐Heterobicyclic Compounds with Grignard Reagents
Authors: Comparini Lucrezia Margherita , Turchi Giovanni , Sardelli Francesca , Favero Lucilla , Di Bussolo Valeria , Di Pietro Sebastiano , Pineschi Mauro 
Published: February 2025

AbstractWe herein report our study about the ring opening of 1,3‐diaza‐4‐oxa‐[3.3.1]‐nonene derivatives with organometallic reagents leveraging on their inherent ring strain and presence of reactive functionalities. The ring‐opening occurs with Grignard reagents at the carbon bearing the two nitrogen atoms affording unconventional functionalized trans‐2,3‐disubstituted 1,2,3,6‐tetrahydropyridines that are important structural frameworks due to their synthetic versatility and presence in bioactive molecules. The possibility to prepare enantioenriched tetrahydropyridines was also formally explored with success. A computational DFT study points to the formation of a transient iminium ion intermediate in which the coordination of magnesium to the oxygen of the carbonyl and the N−O endocyclic oxygen promotes the ring‐opening process at the gem‐diamine carbon atom.
Switchable Site‐Selectivite Direct Acetoxylation of Pyrazolones
Authors: Kittikool Tanakorn , Viriyanukul Tarm , Phakdeeyothin Kunita , Yotphan Sirilata 
Published: February 2025

AbstractSite‐selective direct acetoxylation of pyrazolones was accomplished by utilizing an easy‐to‐handle (diacetoxyiodo)benzene (PIDA) as the sole acetoxylating reagent. In the presence of Pd(OAc)2 catalyst, the 4‐acetoxylated pyrazolone product was exclusively formed. Meanwhile, in the absence of Pd(OAc)2, the pyrazolone methyl acetate product was obtained over the Csp2−H bond functionalization. Both approaches have been successfully applied to various pyrazolone substrates, giving the corresponding products in moderate to high yields under mild conditions.
Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment Before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry
Authors: Matusevicius Marius , Säflund Malin , Balestrino Maurizio , Cappellari Manuel , Ferrandi Delfina , Ghoreishi Abdoreza , Peeters André , Rand Viiu‐Marika , De Michele Manuela , Vilionskis Aleksandras , Zini Andrea , Ahmed Niaz 
Published: February 2025

ObjectivesIntravenous thrombolysis (IVT) is contraindicated for acute ischemic stroke (AIS) patients taking direct oral anticoagulants (DOACs) within 48 hours before index stroke. Limited data exist on off‐label use of IVT for these patients. We compared the safety and outcomes of IVT in AIS patients with DOAC treatment and patients with no OAC before index stroke.MethodsWe analyzed data from the Safe Implementations of Treatments in Stroke (SITS) International Stroke Thrombolysis Registry during 2013–2024. Outcomes were symptomatic intracerebral hemorrhage (SICH) by the SITS Monitoring Study and European Cooperative Acute Stroke Study II definitions, functional independency (modified Rankin Scale score 0–2), and death by 3 months. Propensity score matching with a nearest neighbor matching algorithm with a ratio of 1:2 was used for relevant clinical variables. We also analyzed the time from last DOAC dose to IVT treatment.ResultsA total of 1,311 DOAC and 129,384 no OAC patients were included. We matched 894 patients with DOAC to 1,788 with no OAC. The mean age was 75 years versus 76 years, and the median National Institutes of Health Stroke Scale score 11 versus 12, respectively. Patients with DOAC had a similar proportion of outcomes compared with patients with no OAC: SICH per SITS Monitoring Study (1.1 vs 1.5%, p = 0.50), SICH per European Cooperative Acute Stroke Study II (4.0 vs 4.3%, p = 0.82), any parenchymal hematoma (6.3 vs 7.8, p = 0.22), and functional independency (47.9 vs 46.4%, p = 0.59) and death (25.1 vs 24.0%, p = 0.65) at 3‐month follow‐up. The time from last DOAC dose to IVT did not affect outcomes.InterpretationIn this observational study, we did not find any difference in outcomes after IVT therapy in AIS patients with DOAC compared with no OAC treatment before index stroke. ANN NEUROL 2025