bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential effects of cholesterol levels on cognition according to body mass index in Parkinson’s disease
Authors: Jeong Seong Ho , Chung Seok Jong , Yoo Han Soo , Jung Jin Ho , Baik Jong Sam , Sohn Young H. , Lee Phil Hyu 
Published: January 2024

Abstract
Background
Cholesterol is an essential component of the neuronal cell membrane and is crucial for neuronal function; however, the role of cholesterol levels in Parkinson’s disease (PD) is debatable. This study investigated the complex relationship between total cholesterol (TC) levels, body mass index (BMI), and cognition in patients with PD.

Methods
This study included 321 drug-naïve patients with PD who underwent dopamine transporter (DAT) imaging and baseline neuropsychological tests. Multivariate linear regression and Cox regression models were used to investigate the effect of TC levels on the composite score of each cognitive domain and dementia conversion after adjusting for covariates, respectively. Interaction analyses were performed to examine the interaction effect between TC levels and BMI on baseline cognition and dementia conversion.

Results
TC levels and cognition showed no significant relationship after adjusting for potential confounders. A significant interaction effect between TC levels and BMI was observed in frontal/executive function and dementia conversion. Further analyses showed that TC levels were positively associated with frontal/executive function in the under-/normal weight group (β = 0.205, p = 0.013), whereas a negative relationship existed between TC levels and frontal/executive function in the obese group (β =  − 0.213, p = 0.017). Cox regression analyses also showed the differential effects of TC levels on dementia conversion according to BMI (under-/normal weight group: hazard ratio [HR] = 0.550, p = 0.013; obese group: HR = 2.085, p = 0.014).

Conclusions
This study suggests a cross-over interaction between TC levels and BMI on cognitive symptoms in PD.
Faber polynomial coefficient inequalities for bi-Bazilevič functions associated with the Fibonacci-number series and the square-root functions
Authors: Srivastava H. M. , Khan Shahid , Malik Sarfraz Nawaz , Tchier Fairouz , Saliu Afis , Xin Qin 
Published: January 2024

AbstractTwo new subclasses of the class of bi-Bazilevič functions, which are related to the Fibonacci-number series and the square-root functions, are introduced and studied in this article. Under a special choice of the parameter involved, these two classes of Bazilevič functions reduce to two new subclasses of star-like biunivalent functions related with the Fibonacci-number series and the square-root functions. Using the Faber polynomial expansion (FPE) technique, we find the general coefficient bounds for the functions belonging to each of these classes. We also find bounds for the initial coefficients for bi-Bazilevič functions and demonstrate how unexpectedly these initial coefficients behave in relation to the square-root functions and the Fibonacci-number series.
High-iron consumption decreases copper accumulation and colon length, and alters serum lipids
Authors: Lee Jisu , Lee Hyun-Joo , Jang Hyunsoo , Lee Jae-Joon , Ha Jung-Heun 
Published: January 2024

AbstractIn this study, we aimed to demonstrate that a significant increase in dietary iron intake disrupts the regulation of copper availability, ultimately leading to systemic copper deficiency. To investigate this, we conducted experiments using five-week-old male weanling Sprague–Dawley rats fed diets based on AIN-93G with some modifications. These diets featured varying iron content, offering choices of adequate iron (~ 120 μg/g, near the upper limit [UL]) or high iron (~ 7544 μg/g), along with low (~ 0.3 μg/g), adequate (~ 6 μg/g), or high (~ 153 μg/g) levels of dietary copper over a 5-week period. Rats consuming the high-iron diets displayed anemia, reduced copper levels in their organs and feces, and shortened colon lengths. Increased dietary iron intake resulted in an overall reduction in copper distribution within the body, likely leading to severe copper deficiency-related disorders in the experimental rats. However, the physiological disturbances caused by a high-iron diet were prevented when additional copper was included in the rodent diet. Furthermore, high iron intake led to copper deprivation, and high iron consumption resulted in elevated serum cholesterol levels. However, increasing dietary copper consumption led to a decrease in overall serum cholesterol levels. Additionally, serum alkaline phosphate and aspartate aminotransferase levels were increased by high-iron feeding, regardless of dietary copper concentration, while alanine aminotransferase levels decreased.
SGLT2 inhibitors in peritoneal dialysis: a promising frontier toward improved patient outcomes
Authors: Stepanova Natalia 
Published: January 2024

AbstractPeritoneal dialysis (PD) stands as an important modality among kidney replacement therapies for end-stage kidney disease, offering patients remarkable flexibility and autonomy. Despite its widespread use, challenges such as glucose-related complications, peritoneal membrane fibrosis, declining renal function, and cardiovascular risks persist, necessitating innovative therapeutic approaches. Sodium–glucose cotransporter 2 (SGLT2) inhibitors, originally developed for treating type 2 diabetes mellitus, have recently shown promise as add-on therapy for patients with diabetic and non-diabetic chronic kidney disease (CKD), even in advanced stages. This review describes the potential role of SGLT2 inhibitors as a breakthrough therapeutic option in PD, emphasizing their ability to address unmet clinical needs and improve patient outcomes. The multiple effects of SGLT2 inhibitors in CKD, including metabolic modulation, antihypertensive, diuretic, anemia-reducing, antioxidant, and antiinflammatory properties, are reviewed in the context of PD challenges. Additionally, the potentially protective influence of SGLT2 inhibitors on the integrity of the peritoneal membrane and the transport of solutes and water in the peritoneum are emphasized. Despite these encouraging results, the paper highlights the potential risks associated with SGLT2 inhibitors in PD and emphasizes the need for cautious and thorough investigation of dosing, long-term safety considerations, and patient-specific factors through comprehensive clinical trials. Looking forward, the review argues for well-designed studies to evaluate the expanded safety profile of SGLT2 inhibitors in PD, with particular attention paid to peritoneal membrane integrity and overall patient outcomes.
A Computational Approach: The Functional Effects of Thyroid Peroxidase Variants in Thyroid Cancer and Genetic Disorders
Authors: Sobitan Adebiyi , Gebremedhin Brhan , Yao Qiaobin , Xie Guiqin , Gu Xinbin , Li Jiang , Teng Shaolei 
Published: January 2024

PURPOSE Thyroid peroxidase (TPO) is essential for the synthesis of thyroid hormones. However, specific mutations render TPO antigenic and prone to autoimmune attacks leading to thyroid cancer, TPO deficiency, and congenital hypothyroidism (CH). Despite technological advancement, most experimental procedures cannot quickly identify the genetic causes of CH nor detect thyroid cancer in the early stages. METHODS We performed saturated computational mutagenesis to calculate the folding energy changes (∆∆G) caused by missense mutations and analyzed the mutations involved in post-translational modifications (PTMs). RESULTS Our results showed that the functional important missense mutations occurred in the heme peroxidase domain. Through computational saturation mutagenesis, we identified the TPO mutations in G393 and G348 affecting protein stability and PTMs. Our folding energy calculations revealed that seven of nine somatic thyroid cancer mutations destabilized TPO. CONCLUSION These findings highlight the impact of these specific mutations on TPO stability, linking them to thyroid cancer and other genetic thyroid-related disorders. Our results show that computational mutagenesis of proteins provides a quick insight into rare mutations causing Mendelian disorders and cancers in humans.
Restoring core-periphery structure of networks
Authors: Yang Bo , Li Anqi , Li Nuohan , Pei Zhiyong , Zuo Youcheng 
Published: January 2024

Abstract
Core-periphery structure is commonly observed in diverse real-world networks, where nodes are categorized as core or peripheral nodes by connection patterns. It plays an important role in ensuring potential functionality and intrinsic order in networks. Networks are inevitably suffering from the malicious attacks and random errors, which could lead to the collapse of core-periphery structure, and in turn the performance degradation and even the total instability of network behaviors. Therefore, it is of great significance to rapidly recover such structure after destruction. However, few of the existing works about networks have put emphasis on core-periphery restoration. Here we propose a novel recovery index to characterize and measure the quality for the core-periphery restoration when a disaster happens. Several efficient algorithms guided by our index are devised to provide optimal or near-optimal restoration plans considering both the mesoscale core-periphery structure and global network connectivity. Numerical results are provided to demonstrate the efficacy of our framework that remarkably enhances core-periphery restoration.
Real-Time Intraoperative Ultrasound Using a Minimally Invasive Transducer During Anterior Cervical Spine Surgery
Authors: Chryssikos Timothy , Tawil Michael E. , Ambati Vardhaan S. , Macki Mohamed , DiGiorgio Anthony M. , Mummaneni Praveen V. , Tan Lee 
Published: January 2024

BACKGROUND AND OBJECTIVES:
Intraoperative ultrasound (IOUS) during anterior cervical surgery is hindered by large transducer size and small operative corridor. We hypothesized that a linear (minimally invasive) transducer designed for transsphenoidal surgery can visualize the spinal cord, nerve roots, and surrounding structures during anterior cervical approaches, facilitating intraoperative assessment of central and foraminal decompression.

METHODS:
IOUS was used to evaluate 26 levels in 17 patients (15 anterior cervical discectomy and fusion, 1 corpectomy, 1 arthroplasty) with a linear probe (7 × 6-mm end-fire transducer, 150-mm length, 12–15 MHz). After pin-based distraction, discectomy, and posterior longitudinal ligament resection, IOUS assessed adequacy of cord decompression and, following proximal foraminotomy or uncinectomy, nerve root decompression. If indicated, additional decompression was completed. Criteria for adequate central and foraminal decompression were visualization of subarachnoid space around the cord and cerebrospinal fluid pulsatility along the root sleeve/absence of nerve root compression distal to the root sleeve, respectively.

RESULTS:
IOUS successfully visualized the cord, nerve roots, and surrounding structures in all 26 levels and influenced management in 11 levels (42.3%). IOUS indicated persistent cord and nerve root compression in 2 and 7 levels, respectively. Planned uncinectomy was aborted in 2 levels after IOUS demonstrated adequate nerve root decompression with intervertebral distraction/proximal foraminotomy alone. IOUS identified persistent nerve root compression after initial proximal foraminotomy in 4 levels and uncinectomy in 2 levels. An unplanned uncinectomy was performed in 1 level after IOUS showed persistent nerve root compression after multiple iterations of proximal foraminotomy. At follow-up (mean 3.1 months), the mean improvement in Numeric Rating Scale neck and arm pain, Neck Disability Index, and modified Japanese Orthopedic Association was 4.0%, 3.2%, 3.7%, and 0.7%, respectively.

CONCLUSION:
The neural elements and their relationships to surrounding bone/soft tissue can be visualized using a minimally invasive IOUS transducer during anterior cervical surgery without having to remove pin-based distraction. This allows surgeons to intraoperatively verify the extent of central and foraminal decompression.
The MEK-ERK signaling pathway promotes maintenance of cardiac chamber identity
Authors: Yao Yao , Gupta Deepam , Yelon Deborah 
Published: January 2024

ABSTRACT
Ventricular and atrial cardiac chambers have unique structural and contractile characteristics that underlie their distinct functions. The maintenance of chamber-specific features requires active reinforcement, even in differentiated cardiomyocytes. Previous studies in zebrafish have shown that sustained FGF signaling acts upstream of Nkx factors to maintain ventricular identity, but the rest of this maintenance pathway remains unclear. Here, we show that MEK1/2-ERK1/2 signaling acts downstream of FGF and upstream of Nkx factors to promote ventricular maintenance. Inhibition of MEK signaling, like inhibition of FGF signaling, results in ectopic atrial gene expression and reduced ventricular gene expression in ventricular cardiomyocytes. FGF and MEK signaling both influence ventricular maintenance over a similar timeframe, when phosphorylated ERK (pERK) is present in the myocardium. However, the role of FGF-MEK activity appears to be context-dependent: some ventricular regions are more sensitive than others to inhibition of FGF-MEK signaling. Additionally, in the atrium, although endogenous pERK does not induce ventricular traits, heightened MEK signaling can provoke ectopic ventricular gene expression. Together, our data reveal chamber-specific roles of MEK-ERK signaling in the maintenance of ventricular and atrial identities.
Maximum velocity and leg-specific ground reaction force production change with radius during flat curve sprinting
Authors: Diaz Gabriela B. , Alcantara Ryan S. , Grabowski Alena M. 
Published: January 2024

ABSTRACT
Humans attain slower maximum velocity (vmax) on curves versus straight paths, potentially due to centripetal ground reaction force (GRF) production, and this depends on curve radius. Previous studies found GRF production differences between an athlete's inside versus outside leg relative to the center of the curve. Further, sprinting clockwise (CW) versus counterclockwise (CCW) slows vmax. We determined vmax, step kinematics and individual leg GRF on a straight path and on curves with 17.2 and 36.5 m radii for nine (8 male, 1 female) competitive sprinters running CW and CCW and compared vmax with three predictive models. We combined CW and CCW directions and found that vmax slowed by 10.0±2.4% and 4.1±1.6% (P&lt;0.001) for the 17.2 and 36.5 m radius curves versus the straight path, respectively. vmax values from the predictive models were up to 3.5% faster than the experimental data. Contact length was 0.02 m shorter and stance average resultant GRF was 0.10 body weights (BW) greater for the 36.5 versus 17.2 m radius curves (P&lt;0.001). Stance average centripetal GRF was 0.10 BW greater for the inside versus outside leg (P&lt;0.001) on the 36.5 m radius curve. Stance average vertical GRF was 0.21 BW (P&lt;0.001) and 0.10 BW (P=0.001) lower for the inside versus outside leg for the 17.2 and 36.5 m radius curves, respectively. For a given curve radius, vmax was 1.6% faster in the CCW compared with CW direction (P=0.003). Overall, we found that sprinters change contact length and modulate GRFs produced by their inside and outside legs as curve radius decreases, potentially limiting vmax.
Data Deserts and Black Boxes: The Impact of Socio-Economic Status on Consumer Profiling
Authors: Neumann Nico , Tucker Catherine E. , Kaplan Levi , Mislove Alan , Sapiezynski Piotr 
Published: January 2024

Data brokers use black-box methods to profile and segment individuals for ad targeting, often with mixed success. We present evidence from 5 complementary field tests and 15 data brokers that differences in profiling accuracy and coverage for these attributes mainly depend on who is being profiled. Consumers who are better off—for example, those with higher incomes or living in affluent areas—are both more likely to be profiled and more likely to be profiled accurately. Occupational status (white-collar versus blue-collar jobs), race and ethnicity, gender, and household arrangements often affect the accuracy and likelihood of having profile information available, although this varies by country and whether we consider online or offline coverage of profile attributes. Our analyses suggest that successful consumer-background profiling can be linked to the scope of an individual’s digital footprint from how much time they spend online and the number of digital devices they own. Those who come from lower-income backgrounds have a narrower digital footprint, leading to a “data desert” for such individuals. Vendor characteristics, including differences in profiling methods, explain virtually none of the variation in profiling accuracy for our data, but explain variation in the likelihood of who is profiled. Vendor differences due to unique networks and partnerships also affect profiling outcomes indirectly due to differential access to individuals with different backgrounds. We discuss the implications of our findings for policy and marketing practice. This paper was accepted by David Simchi-Levi, marketing. Funding: Financial support from the National Science Foundation [CAREER Award 6923256] and an anonymous panel company is gratefully acknowledged. Supplemental Material: The web appendix and data files are available at https://doi.org/10.1287/mnsc.2023.4979 .
Building resilience of staff in care homes: preliminary findings of an exploratory study
Authors: Martindale Sheelagh , Will Jill , Wells Julia 
Published: January 2024

Background/Aims Careers in the care home sector have seen innumerable challenges, along with sustaining and growing resilience in the workforce. The aim of this study was to understand the experiences of resilience for care home staff working in one health board area in Scotland. Methods In this exploratory study, five care homes with scores of 6 (1 being the lowest quality, 6 being excellent) within any category available from the Care Inspectorate reports over the previous 12 months were selected and staff members were invited to participate in interviews. Results A total of four staff members from four care homes agreed to participate. Through thematic analysis, three main themes were identified: emotional factors enhancing resilience in staff within care homes; the value of community and the care home family; and encouragement and meaningful interactions from and with others. Conclusions Laughter and happiness for both staff and residents were highlighted and resilience was seen not only at an individual level, but was also attributed to effective team working.
Effect of nursing on postoperative respiratory function and mental health of lung cancer patients
Authors: Yang Xiang , Yin Dan , Chen Shi-Qing 
Published: January 2024

BACKGROUND
Both pulmonary rehabilitation training and psychological care have been shown to have a positive effect on the postoperative recovery of patients with lung cancer. However, few studies have combined the two to explore their combined effect. Therefore, this study aimed to investigate the effects of pulmonary rehabilitation training combined with psychological care on postoperative respiratory function and mental health in lung cancer patients.
AIM
To investigate effect of nursing on postoperative respiratory function and mental health of lung cancer patients.
METHODS
122 cases of lung cancer patients who underwent surgical treatment in our hospital and were treated in our department from January 2022 to April 2023 were selected and randomly divided into the control group and observation group. The control group performed the routine care intervention. The observation group was given pulmonary rehabilitation training and psychological care based on conventional nursing interventions. Forced expiratory volume, forced vital capacity. Maximum ventilatory volume (MVV) in one second was measured, and the patient's 6-min walking distance and dyspnoea index scale were used to assess the patient's respiratory condition. The Connor-Davidson resilience scale (CD-RISC), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) were used to evaluate the mental health of the patients.
RESULTS
There was no difference between the two groups regarding age, gender, education level, surgical procedure, type of pathology, and treatment (P > 0.05). After treatment, MVV, 6-min walking distance, toughness, strength, optimism, and total CD-RISC scores were significantly higher in the observation group (P < 0.05), dyspnoea scores, SAS, and SDS scores were substantially lower in the control group compared to the observation group (P < 0.05).
CONCLUSION
Pulmonary rehabilitation training combined with psychological care for patients after lung cancer resection could improve lung function, enhance daily activities, effectively relieve negative emotions such as anxiety and depression, and reduce complications.
Omental fibroma combined with right indirect inguinal hernia masquerades as a scrotal tumor: A case report
Authors: Zhou Ping , Jin Chan-Hui , Shi Ying , Ma Guo-Qing , Wu Wen-Hao , Wang Yu , Cai Kun , Fan Wu-Feng , Wang Tian-Bao 
Published: January 2024

BACKGROUND
The most common causes of scrotal enlargement in patients include primary tumor of the scrotum, inflammation, hydrocele of the tunica vaginalis, and indirect inguinal hernia; scrotal enlargement caused by external tumors of the scrotum is rare. The patient had both a greater omentum tumor and an inguinal hernia, and the tumor protruded into the scrotum through the hernia sac, which is even rarer. Moreover, omental tumors are mostly metastatic, and primary omental fibroma is rare.
CASE SUMMARY
Here, we report a rare case of a 25-year-old young man with scrotal enlargement and pain for 3 months. Preoperative examination and multidisciplinary discussions considered intra-abdominal tumor displacement and inguinal hernia, and intraoperative exploration confirmed that the greater omentum tumor protruded into the scrotum. Therefore, tumor resection and tension-free inguinal hernia repair were performed. The final diagnosis was benign fibroma of the greater omentum accompanied by an indirect inguinal hernia.
CONCLUSION
This unusual presentation of a common inguinal hernia disease illustrates the necessity of performing detailed history taking, physical examination, and imaging before surgery.