bluuebunny/crossref_metadata_2025_split huggingface dataset:
Framingham risk score based vascular outcomes in acute versus chronic HIV cohorts after 6 years of ART
Authors: Holroyd Kathryn Brown , Han Win Min , Apornpong Tanakorn , Trautmann Lydie , Gatechompol Sivaporn , Hiransuthikul Akarin , Ubolyam Sasiwimol , Sacdalan Carlo , Sriplienchan Somchai , Kanaprach Ratchapong , Kerr Stephen , Avihingsanon Anchalee , Spudich Serena , Chan Phillip 
Published: February 2024

AbstractIntroductionImmune dysregulation persists in people with HIV (PWH) on antiretroviral therapy (ART) and may lead to accelerated vascular ageing and cardiovascular disease (CVD). While delayed time to initiation of ART has been linked to worse cardiovascular outcomes, the effect of ART initiation during acute infection on these outcomes is not well understood.MethodsParticipants were enrolled from the SEARCH010/RV254 acute HIV (AHI) and HIV‐NAT chronic HIV (CHI) cohorts in Thailand. Participants with 6‐year follow‐up and viral suppression (viral load < 50 copies/μL) at follow‐up were included. Both unmatched cohorts and age and gender‐matched cohorts were analysed. Demographics, HIV laboratories, and cardiovascular risk factors from enrolment and 6‐year follow‐up were obtained from electronic records. Framingham Risk Score (FRS), vascular age (VA), vascular age deviation (VAD), and 10‐year atherosclerotic cardiovascular disease (ASCVD) risk were calculated from previously published equations. Vascular outcomes in AHI and CHI cohorts were compared, and univariable and multivariable linear regression analyses were used to investigate risk factors associated with worse vascular scores.ResultsIn all, 373 AHI participants and 608 CHI participants were identified. AHI participants were of younger age, had a higher prevalence of syphilis and a lower prevalence of prior hepatitis B, tuberculosis, diabetes, and hypertension. Higher CD4 T‐cell and lower CD8 T‐cell counts were seen in the AHI cohort at enrolment and 6‐year follow‐up. In all participants, the AHI cohort had a lower median FRS (p < 0.001) and VA (p < 0.001), but higher VAD (p < 0.001). However, in matched cohorts, no differences were found in FRS‐based outcomes. In all participants, higher VAD after 6 years of ART was associated with higher body mass index (p < 0.001) and higher CD4 count (p < 0.001), which persisted in multivariable analysis. When FRS components were analysed individually, CD4 count was associated only with male sex and cholesterol.ConclusionsWe did not identify differences in FRS‐based vascular outcomes at 6 years in matched cohorts of participants who started ART during AHI versus CHI. We identified a correlation between higher CD4 count and worse FRS‐based vascular outcomes, which may be driven by underlying metabolic risk factors. Further study is needed to confirm these findings and evaluate underlying mechanisms.
Effects of preform structure on microstructure and mechanical properties of long/short fiber‐coupled C/C–SiC composites
Authors: Ye Zhiyong , Wang Yalei , Xiong Xiang , Wang Jinming , Li Tongqi , Liu Huaifei , Liu Zaidong , Wei Yanbin 
Published: February 2024

AbstractC/C–SiC composites with four different preform structures were prepared via chemical vapor infiltration and reactive melt infiltration (RMI). The effects of preform structure on the microstructure and mechanical properties of the C/C–SiC composites were thoroughly investigated. The results indicate that the porous C/C composites with multidirectional long/short fiber‐coupling exhibited consistent pore size distribution (diameter: 5–300 µm) and periodicity pore distribution characteristics. As the effective fiber volume fraction in the loading direction of the C/C–SiC composites increased from 11.71% to 21.04%, the tensile and flexural strength significantly increased by 64.44% and 44.03%, respectively, with minimal effect on compressive and interlaminar shear properties. The introduction of Z‐direction fiber, such as stitched structure, increased the compressive and interlaminar shear strength of the composites by 10.87% and 15.67%, respectively. A theoretical predictive model of ultimate tensile strength after modification was validated for application to the C/C–SiC composites prepared by RMI, through characterization of the volume fraction of each layered unit and the content of each component. However, the presence of defects caused by the stitched structure, such as fiber bending, occupancy, and pores, reduced tensile and flexural strength by 30.45% and 28.56%, thereby impacting the effectiveness of the predictive model negatively.
Working from home during the COVID‐19 state of emergency in Japan
Authors: Takami Tomohiro , Yamamoto Yuzo 
Published: February 2024

AbstractThis study examines the impact of working from home on how the working hours of full‐time employees varied by task characteristics during the first COVID‐19 state of emergency in Japan. One of the employment issues during the COVID‐19 pandemic was which type of job maintained working hours despite the spread of infection. Research in various countries argued that working from home effectively maintained normal business operations without interruption. However, Japan's situation regarding working from home and maintaining working hours during the pandemic differed. Under the first state of emergency, the government strongly promoted work‐from‐home measures for office workers, regardless of the tasks they were responsible for at their workplaces. In cases where a task was incompatible with working remotely, work stagnated or ceased entirely, which was reflected in the hours worked. This study considered shortened work hours by not maintaining full‐time work hours during the emergency period as an indicator of the dysfunctional state of business operations. The results demonstrated that work‐from‐home arrangements resulted in shortened work hours if the tasks of workers were incompatible with the scheme. We further revealed a tendency in which work‐from‐home arrangements were discontinued after the emergency period when it involved shortened work hours during the emergency period. The results suggested that work‐from‐home settings are not sustainable beyond emergency situations unless business operations function as indicated by maintaining full‐time work hours.
Immobility in Moldova: Beyond the migration paradigm
Authors: Bogdan Ludmila 
Published: February 2024

AbstractThis paper explores the motivations and barriers behind the decision of economically disadvantaged Moldovans to refrain from migrating for better economic prospects. Drawing on 30 qualitative interviews with voluntary stayers, it uncovers a range of individual‐level characteristics that impede migration aspirations. These findings highlight the heightened sensitivity of lower‐wage stayers to their perceived social status abroad, their limited adaptability to new cultures and environments and their lower willpower to endure the challenges of long‐term gains. Moreover, this paper sheds light on their contentment with modest material gains and their aversion to migration risks. At the structural level, it emphasizes how social inequalities act as barriers for specific social groups, particularly the economically disadvantaged. These empirical insights challenge prevailing assumptions about the dominance of economic costs and network abroad in migration decision‐making, offering a fresh perspective on the social factors and costs shaping stayers' choices.
Prevalence of swallowing difficulties and associated factors in older people with intellectual disabilities
Authors: Sanders Kim J. V. , Elbers Roy G. , Bastiaanse Luc P. , Echteld Michael A. , Evenhuis Heleen M. , Festen Dederieke A. M. 
Published: February 2024

AbstractBackgroundWe investigated the prevalence of swallowing difficulties and associated factors in people with intellectual disability.MethodsWe included people aged 50+ receiving care for people with intellectual disabilities. The Dysphagia Disorder Survey (DDS) was used to assess swallowing difficulties. We determined the agreement between the DDS and swallowing difficulties in medical records. We used logistic regression analyses to explore associated factors.ResultsOne thousand and fifty people were included. The prevalence of swallowing difficulties was 43.8%. Swallowing difficulties were not reported in the medical records of 83.3% of these cases. Frailty (odds ratio (OR) = 4.22, 95% CI = 2.05–8.71), mobility impairment (OR = 2.50, 95% CI = 1.01–6.19), and mealtime dependency (OR = 3.05, 95% CI = 1.10–8.47) were independently associated with swallowing difficulties.ConclusionSwallowing difficulties are prevalent in older people with intellectual disability but may be under‐recognised. Frailty may be a good indicator for population‐based screening for swallowing difficulties.
Incorporating hands‐on experiments into an online science course
Authors: Ye Dan , Pennisi Svoboda , Naranjo Leynar Leyton 
Published: February 2024

AbstractBackgroundWith the rapid proliferation of online education, it is incumbent upon teachers to find ways to provide online students with science laboratory experiences. Existing research on online labs focuses heavily on computer‐supported inquiry learning environments, such as virtual laboratories and remote laboratories. There are limited studies on kitchen labs or home labs.ObjectivesThis study investigated the effectiveness of home labs using lab kits from two perspectives: students' perceptions and experiences of labs conducted in a home environment, as well as whether home labs help with students' knowledge acquisition.MethodsThis study employed lab quizzes to assess students' performance and lab reports to evaluate students' ability to interpret the lab results accurately in the authentic home lab contexts. Surveys and semi‐structured interviews were used to collect students' perceptions and experience data regarding these hands‐on experiments at home.Results and ConclusionsWe found that students' perceptions of home labs are similar to that of face‐to‐face labs, but they generally perceive home labs to be less complex. Students' performances on lab quizzes and lab reports indicate that the majority of them were able to apply the key scientific concepts to accurately interpret lab results in authentic home lab contexts. Students perceived that home labs provide flexibility and help in connecting learning to the real world. However, they also face challenges such as unexpected results and ambiguity during the process.ImplicationsBased on the key findings from this study and our reflections, four practice guidelines were provided for teaching hands‐on experiments online.
Decolonizing education through Ayuuk indigenous praxis: Three visions from Oaxaca, Mexico
Authors: Lebrato Matthew J. 
Published: February 2024

AbstractThis article examines how educators and students at the Instituto Superior Intercultural Ayuuk (ISIA), an intercultural university in Oaxaca, Mexico, are decolonizing education. They do so by drawing on forms of praxis that are salient in Ayuuk indigenous communities, across Oaxaca, and in Latin America. While scholars have demonstrated how indigenous “cosmopolitics” exceeds western norms, research on why some forms of knowledge gain traction outside of their original context has been scant. I utilize the framework of translation to examine three visions of Ayuuk praxis at the ISIA and to suggest why some forms of knowledge are successfully translated across the epistemological boundary between community knowledge and school knowledge. Focusing on the epistemological negotiations between Ayuuk students and professors highlights the challenges of decolonizing education, even when all key actors are indigenous. This work thus contributes to a growing body of scholarship concerned with constructing robustly plural and decolonial societies and institutions.
Cover Image
Authors: Seki Mai , Sano Takaaki , Saito Emi , Ogawa Masaru , Yokoo Satoshi , Oyama Tetsunari 
Published: February 2024

The cover image is based on the Original Article Tertiary lymphoid structures in tongue cancer: Association with clinicopathological parameters, preoperative S‐1 chemotherapy response, and prognosis by Mai Seki et al., https://doi.org/10.1111/jop.13509.image
Fluorescent styrenes for mitochondrial imaging and viscosity sensing
Authors: Singh Deepmala , Ghorpade Mohini , Regar Ramprasad , Collot Mayeul , Soppina Virupakshi , Kanvah Sriram 
Published: February 2024

AbstractFluorophores bearing cationic pendants, such as the pyridinium group, tend to preferentially accumulate in mitochondria, whereas those with pentafluorophenyl groups display a distinct affinity for the endoplasmic reticulum. In this study, we designed fluorophores incorporating pyridinium and pentafluorophenyl pendants and examined their impact on sub‐cellular localization. Remarkably, the fluorophores exhibited a notable propensity for the mitochondrial membrane. Furthermore, these fluorophores revealed dual functionality by facilitating the detection of viscosity changes within the sub‐cellular environment and serving as heavy‐atom‐free photosensitizers. With easy chemical tunability, wash‐free imaging, and a favorable signal‐to‐noise ratio, these fluorophores are valuable tools for imaging mitochondria and investigating their cellular processes.
Iron status and root cell morphology of Arabidopsis thaliana as modified by a bacterial ferri‐siderophore
Authors: Avoscan Laure , Lurthy Tristan , Lherminier Jeannine , Arnould Christine , Loria Pierre‐Manuel , Wu Ting‐Di , Guerquin‐Kern Jean‐Luc , Pivato Barbara , Lemaître Jean‐Paul , Lemanceau Philippe , Mazurier Sylvie 
Published: February 2024

AbstractWe previously provided evidence for the contribution of pyoverdine to the iron nutrition of Arabidopsis. In the present article, we further analyze the mechanisms and physiology of the adaptations underlying plant iron nutrition through Fe(III)‐pyoverdine (Fe(III)‐pvd). An integrated approach combining microscopy and nanoscale secondary ion mass spectrometry (NanoSIMS) on plant samples was adopted to localize pyoverdine in planta and assess the impact of this siderophore on the plant iron status and root cellular morphology. The results support a possible plant uptake mechanism of the Fe(III)‐pvd complex by epidermal root cells via a non‐reductive process associated with the presence of more vesicles. Pyoverdine was transported to the central cylinder via the symplastic and/or trans‐cellular pathway(s), suggesting a possible root‐to‐shoot translocation. All these processes led to enhanced plant iron nutrition, as previously shown. Overall, these findings suggest that bacterial siderophores contribute to plant iron uptake and homeostasis.
Writing and imagining ritual in the Babylonian New Year festival texts
Authors: Debourse Céline 
Published: February 2024

AbstractIn cuneiform culture the New Year Festival was an important ritual of kingship. The most fundamental source for the reconstruction of this festival is a small corpus of cuneiform ritual texts that describe the ritual actions and prayers to be performed during the first days of the year. Those texts were written by Babylonian priests during the Persian‐Hellenistic period (484–140 BCE), when Babylonia had come under foreign rule. Why were these ritual texts outlining a royal ritual created at a time when Babylonia was governed by foreign rulers, who had little interest in Babylonian religious traditions? Why write down rituals at all? In this paper, I show how these New Year Festival texts are programmatic more than instructional, as they give shape to a new ritual paradigm in which Babylonian priests, not kings, are the central authority of the cult.
The effect of parent–adolescent discrepancies in reports of familial dysfunction and depression on suicidal ideation in adolescents
Authors: Sachs Raney , Nakonezny Paul A. , Balzen Kennedy M. , Heerschap Jessica , Kennard Betsy D. , Emslie Graham J. , Stewart Sunita M. 
Published: February 2024

AbstractIntroductionParents and adolescents are often discrepant in their reports of adolescent psychosocial factors. Few studies have addressed parent–adolescent discrepancies in subjective ratings of familial dysfunction and depression as longitudinal predictor variables, and none have done so in a treatment setting for adolescents with acute suicidality. This study examined how parent–adolescent discrepancies in familial dysfunction and depression impact adolescent treatment response in an intensive outpatient program for suicidality.MethodsAdolescents (N = 315) were assessed at treatment entry and exit for familial dysfunction, depression, and suicidal ideation. Parents received parallel assessments of familial dysfunction and adolescent depression at each time point. A polynomial regression was conducted to determine whether parent–adolescent discrepancies in reports of familial dysfunction and depression at entry related to the treatment outcome of adolescent‐reported depression and suicide ideation at exit.ResultsSignificant discrepancies were present with on average adolescents reporting more depression and familial dysfunction than parents. Entry discrepancy in familial dysfunction (but not depression) predicted suicide ideation at exit.ConclusionsOur results suggest that parent–adolescent discrepancies in perception of familial dysfunction is a risk factor for poor outcomes in suicidal youth and might be a fruitful target in treatment programs.
Unique high-temperature tolerance mechanisms of zoochlorellae
Symbiochlorum hainanensis
derived from scleractinian coral
Porites lutea
Authors: Xiao Yilin , Gao Luyao , Li Zhiyong 
Published: February 2024

ABSTRACT

Global warming is a key issue that causes coral bleaching mainly because of the thermosensitivity of zooxanthellae. Compared with the well-studied zooxanthellae Symbiodiniaceae in coral holobionts, we rarely know about other coral symbiotic algae, let alone their thermal tolerance. In this study, a zoochlorellae,
Symbiochlorum hainanensis,
isolated from the coral
Porites lutea,
was proven to have a threshold temperature of 38°C. Meanwhile, unique high-temperature tolerance mechanisms were suggested by integrated transcriptomics and real-time quantitative PCR, physiological and biochemical analyses, and electron microscopy observation. Under heat stress,
S. hainanensis
shared some similar response strategies with zooxanthellae
Effrenium
sp., such as increased ascorbate peroxidase, glutathione peroxidase, superoxide dismutase activities and chlorophyll a, thiamine, and thiamine phosphate contents. In particular, more chloroplast internal layered structure, increased CAT activity, enhanced selenate reduction, and thylakoid assembly pathways were highlighted for
S. hainanensis
’s high-temperature tolerance. Notably, it is the first time to reveal a whole selenate reduction pathway from SeO
4
2−
to Se
2−
and its contribution to the high-temperature tolerance of
S. hainanensis
. These unique mechanisms, including antioxidation and maintaining photosynthesis homeostasis, efficiently ensure the high-temperature tolerance of
S. hainanensis
than
Effrenium
sp. Compared with the thermosensitivity of coral symbiotic zooxanthellae Symbiodiniaceae, this study provides novel insights into the high-temperature tolerance mechanisms of coral symbiotic zoochlorellae
S. hainanensis
, which will contribute to corals’ survival in the warming oceans caused by global climate change.

IMPORTANCE

The increasing ocean temperature above 31°C–32°C might trigger a breakdown of the coral-Symbiodiniaceae symbioses or coral bleaching because of the thermosensitivity of Symbiodiniaceae; therefore, the exploration of alternative coral symbiotic algae with high-temperature tolerance is important for the corals’ protection under warming oceans. This study proves that zoochlorellae
Symbiochlorum hainanensis
can tolerate 38°C, which is the highest temperature tolerance known for coral symbiotic algae to date, with unique high-temperature tolerance mechanisms. Particularly, for the first time, an internal selenium antioxidant mechanism of coral symbiotic
S. hainanensis
to high temperature was suggested.
Impact of immunosuppressive therapy on SARS-CoV-2 mRNA vaccine effectiveness in patients with immune-mediated inflammatory diseases: a Danish nationwide cohort study
Authors: Elmahdi Rahma , Ward Daniel , Ernst Martin T , Poulsen Gry , Hallas Jesper , Pottegård Anton , Jess Tine 
Published: February 2024

ObjectivePatients receiving immunosuppressives have been excluded from trials for SARS-CoV-2 vaccine efficacy. Investigation of immunosuppressants’ impact on effectiveness of vaccines, particularly in patients with immune-mediated inflammatory diseases (IMID), is therefore required.DesignWe performed a nationwide cohort study to assess the risk of COVID-19 infection in vaccinated patients with IMID exposed to immunosuppressives compared with IMID unexposed to immunosuppressives. Exposure to immunosuppressives in the 120 days before receiving the second SARS-CoV-2 mRNA vaccination was assessed. Patients were followed from date of second vaccination and weighted Cox models were used to estimate the risk of infection associated with immunosuppressives. Secondary outcomes included hospitalisation and death associated with a positive SARS-CoV-2 test. Risk of infection by immunosuppressant drug class was also analysed.SettingThis study used population-representative data from Danish national health registries in the period from 1 January to 30 November 2021.ResultsOverall, 152 440 patients were followed over 19 341 person years. Immunosuppressants were associated with a significantly increased risk of infection across IMID (HR: 1.4, 95% CI 1.2 to 1.5), in inflammatory bowel disease (IBD) (HR: 1.6, 95% CI 1.4 to 1.9) and arthropathy (HR: 1.3, 95% CI 1.1 to 1.4) but not psoriasis (HR: 1.1, 95% CI 0.9 to 1.4). Immunosuppressants were also associated with an increased risk of hospitalisation across IMID (HR: 1.4, 95% CI 1.1 to 2.0), particularly in IBD (HR: 2.1, 95% CI 1.0 to 4.1). No significantly increased risk of death in immunosuppressant exposed patients was identified. Analyses by immunosuppressant drug class showed increased COVID-19 infection and hospitalisation with anti-tumour necrosis factor (TNF), systemic corticosteroid, and rituximab and other immunosuppressants in vaccinated patients with IMID.ConclusionImmunosuppressive therapies reduced effectiveness of mRNA SARS-CoV-2 vaccination against infection and hospitalisation in patients with IMID. Anti-TNF, systemic corticosteroids, and rituximab and other immunosuppressants were particularly associated with these risks.