bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possession Rights over Reclaimed Land: A Legal Analysis of Foreign Legal Entities Ownership Status
Authors: Suganda Yosua Simon 
Published: November 2023

Rapid population growth without a corresponding increase in land availability can lead to issues such as a significant long-term rise in land prices. Reclamation emerges as an option to assist communities in obtaining land at affordable prices. However, the implementation of reclamation must adhere to the terms and regulations set by the government, including provisions related to foreign legal entities intending to engage in reclamation activities. This article employs a normative juridical approach and juridical analysis methods. The findings indicate that foreign legal entities can undertake reclamation activities by legal requirements governing individual and corporate legal entities, whether local or foreign, provided they have obtained reclamation permits. Foreign legal entities are allowed to have land rights in the reclaimed area, but the land status is in the form of usage rights and lease rights after obtaining permission from the government. In conclusion, implementing reclamation by foreign legal entities necessitates compliance with applicable regulations and requirements to ensure the sustainability and success of these activities. Pertumbuhan penduduk yang cepat tanpa disertai peningkatan luas lahan dapat menimbulkan masalah, seperti kenaikan harga tanah yang signifikan dalam jangka panjang. Reklamasi menjadi opsi untuk membantu masyarakat memperoleh tanah dengan harga terjangkau. Namun, pelaksanaan reklamasi harus mematuhi syarat dan ketentuan pemerintah, termasuk ketentuan terkait subjek hukum asing yang ingin melakukan kegiatan reklamasi. Artikel ini menggunakan pendekatan yuridis normatif dan metode analisis yuridis. Hasil kajian menunjukkan bahwa subjek hukum asing dapat melakukan reklamasi sesuai dengan persyaratan hukum yang mengatur subjek hukum baik perorangan maupun badan hukum, baik lokal maupun asing, asalkan telah memperoleh izin reklamasi. Untuk subjek hukum asing, diperbolehkan memiliki hak atas tanah reklamasi, namun status tanahnya berupa hak pakai dan hak sewa setelah mendapatkan izin dari pemerintah. Kesimpulannya, penerapan reklamasi oleh subjek hukum asing memerlukan ketaatan terhadap regulasi dan persyaratan yang berlaku untuk memastikan keberlanjutan dan keberhasilan kegiatan tersebut.
Quercetin and microRNA Interplay in Apoptosis Regulation: A New Therapeutic Strategy for Cancer?
Authors: Wang Zicheng , Liu Yanqing , Asemi Zatollah 
Published: November 2023

Abstract:
Cancer is known as a global problem for the health and economy. Following
cancer onset, apoptosis is the primary mechanism countering the tumor cells' growth.
Most anticancer agents initiate apoptosis to remove tumor cells. Phytochemicals have appeared
as a beneficial treatment option according to their less adverse effects. In recent
decades, quercetin has been highlighted due to its high pharmacological benefits, and
various literature has suggested it as a potential anti-proliferative agent against different
kinds of cancers. The microRNAs (miRNAs) play key roles in cancer treatment, progression,
and apoptosis. This review reviewed the effect of quercetin on miRNAs contributing
to the induction or inhibition of apoptosis in cancers.
Reduced Tumor Volume and Increased Necrosis of Human Breast Tumor
Xenograft in Mice Pretreated by a Cocktail of Three Specific Anti-HER2
scFvs
Authors: Nejatollahi Foroogh , Nadimi Elham , Noorafshan Ali , Moazen Setareh , Alizadeh Ali Mohammad , Khalighfard Solmaz , Sahebkar Amirhossein 
Published: November 2023

Purpose:
We aimed to assess the effects of a cocktail comprising three specific anti-
HER2 scFvs on breast tumor formation in a xenograft mouse model and to evaluate quantitative
changes in the tumor using stereological analysis.

Methods:
Three specific anti-HER2 phage antibodies were produced from a scFv-library using
phage display technology. The cell binding capacities of the antibodies were assessed via FACS
analysis. Soluble forms of the antibodies were prepared by infecting HB2151-E. coli cells and purified
using a centrifugal ultrafiltration method. The purification process was evaluated by SDSPAGE
analysis. Two forms of scFv cocktails were prepared, soluble scFv and phage-scFv cocktail,
which contained an equal amount/phage of each of the three antibodies. Inbred female BALB/c
mice were pretreated with 5 and 20 mg/kg of the soluble scFv cocktail and 1011 phage-scFv cocktail/
kg. The mice were then injected with 2×106 SKBR-3 human breast cancer cells. Total tumor,
inflammatory and non-inflammatory volumes were estimated using the Cavalieri principle after
preparing photomicrograph slides.

Results:
The anti-HER2 scFvs showed significantly higher binding to SKBR-3 cells compared to
the isotype control. SDS-PAGE analysis confirmed the high purification of the scFvs. Stereological
analysis revealed that the group pretreated with 20 mg/kg of the soluble scFv cocktail exhibited the
highest reductions in total tumor volume, non-inflammatory volume, and inflammatory volume,
with reductions of 73%, 78%, and 72%, respectively, compared to PBS-pretreated mice (P-value <
0.0001). The volumetric ratio of necrotic tissue to total tumor volume increased by 2.2-fold and 2-
fold in the 20mg/kg of soluble scFv cocktail and phage-scFv cocktail groups, respectively, compared
to the PBS-treated mice (P-value < 0.05).

Conclusion:
Pre-treatment with a 20 mg/kg anti-HER2 scFv cocktail resulted in a significant reduction
in tumor volume and increased necrotic area in a human breast cancer xenograft model,
indicating the remarkable anti-tumor effect of the cocktail in vivo.
Biomarkers and Treatment Strategies for Breast Cancer Recurrence
Authors: Rajput Shivam , Sharma Pramod Kumar , Malviya Rishabha 
Published: November 2023

Abstract:
Despite recent treatment advancements, breast cancer remains a life-threatening disease.
Although treatment is successful in the early stages, a significant proportion of individuals
with breast cancer eventually experience a recurrence of the disease. Breast tumour recurrence poses
a significant medical issue. Despite tumours being a primary cause of mortality, there remains a
limited understanding of the fundamental mechanisms underlying tumour recurrence. The majority
of the time, after surgery or medical treatment, this metastatic disease manifests itself after the
disease is undiagnosed for a considerable amount of time. This phenomenon is commonly referred
to as a relapse or recurrence. Metastatic breast cancer has the potential to recur at varying intervals,
ranging from a few months to several decades following the initial diagnosis and treatment.
This article aimed to summarise the primary causes of breast cancer recurrence and highlight the
key issues that need to be addressed in order to effectively decrease the mortality rate among
breast cancer patients. This article discusses various therapeutic approaches currently employed
and emerging treatment strategies that hold the potential for the complete cure of cancer.
Adherence to Congestive Heart Failure Guidelines and Outcome in the
Middle East
Authors: Aqel Raed , Alzughayyar Tareq , Zalloum Jihad , Salah Qais , Qafisheh Qutaiba , Izraiq Mahmoud 
Published: November 2023

Background::
Adherence to Congestive Heart Failure with reduced Ejection Fraction
(CHFrEF) guidelines is not easily attainable everywhere, particularly in countries with a high
prevalence of low socioeconomic status, which includes many Middle Eastern countries. However,
it is well-established that adherence to the guidelines is associated with lower mortality and
morbidity rates.

Objective::
Our objective is to investigate the adherence to the degree of treatment guideline in
CHFrEF within a patient population in the Middle East and correlate the level of compliance
both fully and partially with morbidity and mortality outcomes.

Methods and Statistics:
We conducted a retrospective study on patients with CHFrEF in the
Middle East region who were maintained on Sacubitril/Valsartan for up to 4 years (190 patients).
This study included follow-up assessments for morbidity and mortality rates and their
correlation with the level of adherence to guidelines.

Results::
Statistical analysis was performed using IBM SPSS® 27th version. In both the partial
adherence group and the full adherence group, there was a statistically significant improvement
in NYHA (pretreatment and post-treatment) and Ejection fraction (pretreatment and posttreatment).
This means that regardless of the level of adherence to the use of Sacubitril/Valsartan
in CHFrEF, there was an overall improvement in the morbidity and mortality rates over the four
years of follow-up.

Conclusion::
While we fully support the idea of achieving full CHFrEF guideline adherence, we
recognize the difficulty of this task. Nevertheless, this study reinforces the notion that any degree
of adherence to guideline is correlated with better morbidity and mortality rates over a
long-term follow-up.
Effect of Bombyx Mori Silk Fiber Volumetric on Water Sorption of Fiber-reinforced Composite
Authors: Fransiska Aria , Sunarintyas Siti , Dharmastiti Rini 
Published: November 2023

Background:
Dental resin is frequently reinforced with synthetic dental fibers like glass fiber. Dental glass fiber can be challenging to find and costly in Indonesia. Bombyx mori silk fiber is a robust, convenient, and reasonably priced natural fiber substitute. Bombyx mori silk fiber is commonly used in medicinal applications as a post-surgical suture.

Aim:
The aim of this study was to assess the volumetric effect of Bombyx mori silk fiber on the water sorption of fiber-reinforced composite (FRC).

Material and Methods:
This study was an experimental laboratory. The materials used in this study were Bombyx mori silk fiber and flowable composite. Four groups of FRC samples were made using volumetric fibers at 0%, 5%, 10%, and 15% (n = 4). The test of water sorption was standardized (ISO 4049). The results were analyzed using one-way ANOVA (p<0.05).

Results:
The mean of water sorption of Bombyx mori silk fiber FRC for volumetric 0%, 5%, 10%, and 15% were: 0.475±0.030%; 0.681±0.033%; 0.889±0.008%; 1.318±0.039%, respectively. The present study showed that Bombyx mori silk fiber volumetric influenced the water sorption of FRC (p<0.05).

Conclusion:
The increased Bombyx mori silk fiber volumetric significantly increased the water sorption of FRC. The presence of a small gap caused by the weak interfacial bonds of the dental resin and fiber leads to water penetration.
Visual and Instrumental Color Match Evaluation of Single Shade Composites before and after Bleaching Procedures: A Pilot Study
Authors: Forabosco Eleonora , Checchi Vittorio 
Published: November 2023

Background:
One of the major challenges in restorative dentistry is to obtain an adequate color match between composite restorations and the surrounding tooth. This match depends on several chromatic variables related to the composite itself but also to the teeth. Bleaching procedures are not to be able to modify the shade of composite restorations to a lighter color as it does on natural teeth.

Objective:
The objective of this study is to evaluate the visual and instrumental color match of two single-shade resin-based composites in human-extracted teeth before and after bleaching treatment.

Methods:
Six extracted human posterior sound teeth were used. Round-shaped V-class cavities (2x2x4mm) were prepared buccally 2mm away from the CEJ. Two single-shade resin composites (OM-Omnichroma and VE-Venus Diamond One) were used for the restorations. Tooth color was measured using an intraoral spectrophotometer. Visual analysis was carried out by 16 calibrated observers, and the differences were graded from 0 (excellent match) to 4 (huge mismatch). Teeth were then bleached using 40% H
2O2 (Opalescence Boost PF, Ultradent), and visual and instrumental evaluations were performed after 24 hours.

Results:
Before bleaching, visual analysis showed a mean value of 0.16 for OM and 0.24 for VE. After bleaching, the color match showed a mean value of 0.14 for OM and 0.22 for VE. Regarding the instrumental analysis, each restoration matched the tooth VITA scale grade before bleaching and followed the natural tooth VITA scale grade after bleaching procedures.

Conclusion:
Within the limits of this pilot study, both composites seem to have excellent color-match properties with the surrounding tooth structure.
Effect of Glutaraldehyde on Dentin Hypersensitivity after Non-surgical Periodontal Therapy: A Randomized, Triple-blinded Clinical Study
Authors: Silva Fábio Alves , Oliveira Barros Antonia Patricia , de Melo Alencar Cristiane , Carneiro Alexandra Melo Pingarilho , Silva Cecy Martins 
Published: November 2023

Aims and Objectives:The purpose of this study was to evaluate the effect of 5% glutaraldehyde (5% Gluma), in association with 37% phosphoric acid conditioning, on dentin hypersensitivity (DH) after non-surgical periodontal treatment (NSPT). Additionally, we investigated the impact of these treatments on health-related quality of life (HRQoL).Methods:Ninety hypersensitive teeth of subjects were randomized into the following three groups based on treatment (n = 30): GP: placebo gel that simulates 37% phosphoric acid (37% PA) + distilled water, GPG: placebo gel that simulates 37% PA + 5% Gluma, and GAG: 37% PA + 5% Gluma. Two visual analog scales (VASs) were used to measure DH after tactile and evaporative stimulation four times. The HRQoL was recorded using a DH experience questionnaire (DHEQ). Statistical analysis of DH data was performed using Friedmanvs.Kruskal-Wallis tests. DHEQ data were analyzed using Wilcoxonvs.Mann–Whitney tests and a simple logistic regression (α= 0.05).Results:The GPG and GAG groups showed significantly lower DH than GP (p ≤ 0.05) for tactile and evaporative stimulations. After one month of follow-up, the GPG and GAG groups showed an increase in HRQoL, which was higher than that of the GP group (p ≤ 0.05). Gluma (5%) effectively prevented DH for up to 15 days after NSPT, regardless of previous conditioning with phosphoric acid. In addition, treatment with 5% gluma had a positive impact on HRQoL.Conclusion:The treatment with 5% glutaraldehyde was effective in HD and had a positive impact on quality of life.Clinical Trial Registration Number:The clinical trial registration number for this study is NCT04207450.
Pengaruh Rendam Kaki Air Hangat Terhadap Kualitas Tidur Pada Lansia: Literature Review
Authors: Anggraini Efi , Wijoyo Eriyono Budi , Kartini Kartini , Hastuti Hera , Yoyoh Imas 
Published: November 2023

ABSTRAKLansia merupakan tahap akhir dari siklus hidup manusia, yaitu bagian dari proses kehidupan yang tidak dapat dihindari dan akan di alami oleh setiap individu. Pada proses penuaan akan terjadi penurunan, kemunduran dan perubahan fungsi baik fungsi biologis dan fisiologis, sosial, psikologis meliputi depresi, cemas, tidak konsentrasi, koping tidak efektif. Lansia sebagian besar berisiko tinggi mengalami gangguan tidur yang disebabkan oleh berbagai faktor. Salah satu gangguan tidur pada lansia yaitu, Insomnia/kesulitan tidur. Salah satu terapi non farmakologi untuk pemenuhan kebutuhan tidur ialah rendam kaki menggunakan air hangat atau hydrotherapy. Tujuan: untuk mengetahui pengaruh rendam kaki air hangat terhadap kualitas tidur pada lanisa secara kajian literatur. Metodelogi: pencarian artikel menggunkan Google Schoolar, PubMed, Medline database untuk menentukan artikel sesuai dengan kriteria inklusi dan eklusi kemudian dilakukan review. Hasil: Hasil penelitian menunjukan bahwa rendam kaki air hangat memiliki pengaruh yang signifikan terhadap kualitas tidur pada lansia. Hal ini bisa dibuktikan Setelah dilakukan intervensi menunjukkan bahwa mayoritas responden mempunyai total tidur 5-7 jam, waktu untuk tidur lebih cepat, frekuensi terbangun dimalam hari berkurang, tidur nyenyak dan responden mengatakan puas dalam tidurnya. Kesimpulan: terapi rendam kaki air hangat baikdilakukan dengan adanya campuran seperti aromaterapi lavender ataupun larutan garam masing-masing jenis tersebut dapat membantu meningkatkan kualitas tidur pada lansia. Kata Kunci: Rendam Kaki, Air Hangat, Kualitas Tidur, Lansia
KAPASITAS ORGANISASI DINAS PERTANIAN TANAMAN PANGAN DAN HORTUKULTURA PROVINSI JABAR DALAM PENGEMBANGAN BENIH PADI INDUK
Authors: Iqbal Mohammad , Myrna Rita , Susanti Elisa 
Published: November 2023

One aspect of the low achievement of parent rice seeds is due to the capacity of the Department of Agriculture for Food Crops and Horticulture of West Java Province in carrying out their duties to reproduce rice seeds that are not optimal. This research aims to see the capacity of the Department of Agriculture, Food Crops and Horticulture, West Java Province. The aspects used in this descriptive qualitative research are (1) personnel, (2) infrastructure, technology, and financial resources, (3) strategic leadership, (4) program and process management, and (5) networking and linkages. Salah satu aspek rendahnya pencapaian benih padi induk diakibatkan kapasitas Dinas Pertanian Tanaman Pangan dan Hortikultura Provinsi Jawa Barat dalam melakukan tugasnya dalam rangka memperbanyak benih padi belum optimal. Tujuan dilakukan penelitian ini guna melihat Kapasitas Dinas Pertanian Tanaman Pangan dan Hortikultura Provinsi Jawa Barat. Aspek yang digunakan dalam riset kualitatif deskriptif ini yakni( 1) personnel ( sumber daya manusia), (2) infrastucture, technology, and financial resources (infrastruktur, teknologi, serta sumber daya keuangan), (3) strategic leadership (kepemimpinan strategis), (4) program and process management (program serta manajemen proses), serta (5) networking and linkages (jejaring kerjasama serta ikatan dengan pihak lain).
EFEKTIVITAS PEMERIKSAAN PAJAK PADA WAJIB PAJAK BADAN DI KANTOR PELAYANAN PAJAK PRATAMA MEDAN BARAT
Authors: Tobing Angelia Tio , Candradewini Candradewini , Munajat Mas Dadang Enjat 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis terkait pemeriksaan pajak di Kantor Pelayanan Pajak Pratama Medan Barat. Kondisi Kota Medan saat ini memiliki tingkat penduduk tinggi ditambah dengan perekonomian tinggi memberikan kemungkinan beberapa wajib pajak lalai menunjukkan kepatuhannya terhadap kewajiban perpajakannya. Identifikasi masalah pada penelitian ini adalah bagaimana efektivitas pemeriksaan pajak pada wajib pajak badan di Kantor Pelayanan Pajak Pratama Medan Barat. Peneliti memakai metode penelitian deskriptif kualitatif serta teknik pengumpulan data memakai studi kepustakaan serta studi lapangan. Hasil dari penelitian ini menunjukkan bahwa berdasarkan indikator efektivitas pemeriksaan pajak yang dijelaskan oleh Richard M Steers (2020) yaitu integrasi, pencapaian tujuan, dan adaptasi didapatkan bahwa proses pelaksanaan pemeriksaan pajak sudah berjalan dengan baik dan sudah sesuai dengan pedoman pemeriksaan perpajakan serta regulasi yang ada tetapi memang dalam pelaksanaanya belum efektif. Hal ini terlihat dari berbagai kendala selama pemeriksaan pajak, dimulai dari keterbatasan pegawai hingga ruang lingkup pekerjaan yang terlalu luas. Hal ini menyebabkan pemeriksaan pajak tidak dapat mencapai target yang ditentukan. Kantor Pelayanan Pajak Pratama Medan Barat diharapkan dapat mencegah serta mengurangi kendala yang ada sehingga proses pelaksanaan pemeriksaan pajak dapat berjalan dengan lebih efektif dan lebih baik. The research objective is to find out and analyze related tax audits at the KPP Pratama Medan Barat. The current condition of the City of Medan has a high population rate, with a high economy, it is possible for some taxpayers to fail to show compliance with their tax obligations. Identification of the problem in this study is how the effectiveness of tax audits on corporate taxpayers at the KPP Pratama Medan Barat. baratresearchers used descriptive qualitative research methods and data collection techniques using library research and field studies. The results of this study indicate that based on the indicators of the effectiveness of tax audits described by richard m steers (2020) of integration, goal achievement, and adaptation, it was found that the process the implementation of the tax audit has been running well in accordance with the tax audit guidelines, but has not been effective. This can be seen from the various obstacles during the tax audit, starting from the limited number of employees to the scope of work that is too broad. This causes the tax audit can not reach the specified target. KPP Pratama Medan is expected to be able to prevent and reduce existing obstacles so that the tax audit implementation process can run more effectively and better.
POPULATION DOCUMENTATION OF PELUNG CHICKEN IN FIVE SUB DISTRICTS IN GARUT REGENCY
Authors: Mahdayanti Wulan Anisha , Asmara Indrawati Yudha , Garnida Dani 
Published: November 2023

Pelung chicken is a local Indonesian chicken originating from Cianjur. The Pelung population data is still not known with certainty. This study aims to obtain the total and structure of population, determine the effective population size (Ne), and the rate of inbreeding (∆F) in Pelung chickens in five districts in Garut Regency. This research was conducted from May to June 2022 in Cikajang, Pasirwangi, Bayongbong, Samarang, and Cigedug Districts. The study used, quantitative descriptive methods and data were obtained by direct interview techniques in which a total of respondents were interviewed. The results of the study showed that the total population of Pelung chickens at the research location was 1,867 Pelung chickens with 452 birds in district of Cikajang, 316 of Pasirwangi, 555 of Bayongbong, 194 of Samarang, and 350 of Cigedug. The total number of effective population sizes at the study site was 465 individuals. The inbreeding rate per generation in five sub-districts was 0.1%, with the highest inbreeding rates in Samarang 0.82%, followed by Cigedug 0.78%, Pasirwangi 0.54%, Cikajang 0.42%, and Bayongbong 0.39%.
The Effect of Stocking Density on Performance of Padjadjaran Broiler Quail
Authors: Marwati Rina , Setiawan Iwan , Sujana Endang 
Published: November 2023

This research's purpose was to determine the effect of stocking density on the performance of Padjadjaran broiler quails (feed consumption, body weight gain, and feed conversion ratio). This experiment used 90 day old quails (DOQ) of Padjadjaran broilers quail and raised them for 6 weeks from 23 January until 5 March 2023 at the Quail Breeding Center, Faculty of Animal Husbandry, Padjadjaran University. The research used an experimental method with a complete randomized design (CRD). The stocking density treatment was applied to quails starting at the age of 3 to 6 weeks, consisting of P1 (stocking density of 40 birds per m2), P2 (stocking density of 50 birds per m2), and P3 (stocking density of 60 birds per m2). Each treatment was replicated 6 times with each replicate containing 5 quails. Data on feed consumption, body weight gain and feed convertion ratio were analyzed by variance analysis and to determine differences between treatments were tested using Duncan's Multiple Range Test. The results showed that stocking density had no effect (P>0.05) on the performance of Padjadjaran broiler quails. Based on the results of the study, we concluded that stocking densities of up to 60 birds per m2 still provide a good performance in Padjadjaran broiler quails.