bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data
Authors: Zohud Osayd , Lone Iqbal M. , Nashef Aysar , Iraqi Fuad A. 
Published: December 2023

AbstractHead and neck squamous cell cancer (HNSCC) is a leading global malignancy. Every year, More than 830 000 people are diagnosed with HNSCC globally, with more than 430 000 fatalities. HNSCC is a deadly diverse malignancy with many tumor locations and biological characteristics. It originates from the squamous epithelium of the oral cavity, oropharynx, nasopharynx, larynx, and hypopharynx. The most frequently impacted regions are the tongue and larynx. Previous investigations have demonstrated the critical role of host genetic susceptibility in the progression of HNSCC. Despite the advances in our knowledge, the improved survival rate of HNSCC patients over the last 40 years has been limited. Failure to identify the molecular origins of development of HNSCC and the genetic basis of the disease and its biological heterogeneity impedes the development of new therapeutic methods. These results indicate a need to identify more genetic factors underlying this complex disease, which can be better used in early detection and prevention strategies. The lack of reliable animal models to investigate the underlying molecular processes is one of the most significant barriers to understanding HNSCC tumors. In this report, we explore and discuss potential research prospects utilizing the Collaborative Cross mouse model and crossing it to mice carrying single or double knockout genes (e.g. Smad4 and P53 genes) to identify genetic factors affecting the development of this complex disease using genome‐wide association studies, epigenetics, microRNA, long noncoding RNA, lncRNA, histone modifications, methylation, phosphorylation, and proteomics.
Acid‐Cleavable Aromatic Polymers for the Fabrication of Closed‐Loop Recyclable Plastics with High Mechanical Strength and Excellent Chemical Resistance
Authors: Lu Xingyuan , Xie Peng , Li Xiang , Li Tianqi , Sun Junqi 
Published: December 2023

AbstractAlthough closed‐loop recycling of dynamic covalent bond‐based plastics does not require catalysts, their mechanical strength and chemical stability remain a major concern. In this study, closed‐loop recyclable poly(aryl imine) (PAI) plastics with high mechanical strength and excellent chemical resistance are fabricated by copolymerizing aromatic amines and aromatic aldehydes through dynamic imine bonds. The resulting PAI plastic with a tensile strength of 58.2 MPa exhibits excellent chemical resistance and mechanical stability in acidic and basic aqueous solutions and various organic solvents. The PAI plastics can be depolymerized in a mixed solvent of tetrahydrofuran (THF)/HCl aqueous solution through the dissociation of imine bonds, and the monomers can be facilely recovered with high purity and isolated yields due to the solubility difference between the aromatic amines and aromatic aldehydes in selective solvents. The efficient closed‐loop recycling of the PAI plastic can also be realized through monomer conversion because the hydrolysis of the aromatic aldehydes generates aromatic amines. The recovered monomers can be used to re‐fabricate original PAI plastics. This PAI plastic can be selectively recovered from complicated mixed polymer waste streams due to the mild depolymerization conditions of the PAI plastic and its high stability in most organic solvents.
Crystalline Dual‐Porous Covalent Triazine Frameworks as a New Platform for Efficient Electrocatalysis
Authors: Cui Kai , Tang Xiaoliang , Xu Xiaopei , Kou Manchang , Lyu Pengbo , Xu Yuxi 
Published: December 2023

AbstractCrystalline covalent triazine frameworks (CTFs) have gained considerable interest in energy and catalysis owing to their well‐defined nitrogen‐rich π‐conjugated porosity and superior physicochemical properties, however, suffer from very limited molecular structures. Herein we report a novel solvent‐free FeCl3‐catalyzed polymerization of 2, 6‐pyridinedicarbonitrile (DCP) to achieve the first synthesis of crystalline, dual‐porous, pyridine‐based CTF (Fe‐CTF). The FeCl3 could not only act as a highly active Lewis acid catalyst for promoting the two‐dimensional ordered polymerization of DCP monomers, but also in situ coordinate with the tridentate chelators generated between pyridine and triazine groups to yield unique Fe‐N3 single‐atom active sites in Fe‐CTF. Abundant few‐layer crystalline nanosheets (Fe‐CTF NSs) could be prepared through simple ball‐milling exfoliation of the bulk layered Fe‐CTF and exhibited remarkable electrocatalytic performance for oxygen reduction reaction (ORR) with a half‐wave potential and onset potential up to 0.902 and 1.02 V respectively, and extraordinary Zn‐air battery performance with an ultrahigh specific capacity and power density of 811 mAh g−1 and 230 mW cm−2 respectively. By combining operando X‐ray absorption spectroscopy with density functional theory calculations, we revealed a dynamic and reversible evolution of Fe‐N3 to Fe‐N2 during the electrocatalytic process, which could further accelerate the electrocatalytic reaction.
Self‐reporting and Biodegradable Thermosetting Solid Polymer Electrolyte
Authors: Zhou Ya‐Nan , Yong Haiyang , Guo Rui , Wang Kaixuan , Li Zhili , Hua Weibo , Zhou Dezhong 
Published: December 2023

AbstractTo date, significant efforts have been dedicated to improve their ionic conductivity, thermal stability, and mechanical strength of solid polymer electrolytes (SPEs). However, direct monitoring of physical and chemical changes in SPEs is still lacking. Moreover, existing thermosetting SPEs are hardly degradable. Herein, by overcoming the limitation predicted by Flory theory, self‐reporting and biodegradable thermosetting hyperbranched poly(β‐amino ester)‐based SPEs (HPAE‐SPEs) are reported. HPAE is successfully synthesized through a well‐controlled “A2+B4” Michael addition strategy and then crosslinked it in situ to produce HPAE‐SPEs. The multiple tertiary aliphatic amines at the branching sites confer multicolour luminescence to HPAE‐SPEs, enabling direct observation of its physical and chemical damage. After use, HPAE‐SPEs can be rapidly hydrolysed into non‐hazardous β‐amino acids and polyols via self‐catalysis. Optimized HPAE‐SPE exhibits an ionic conductivity of 1.3×10−4 S/cm at 60 °C, a Na+ transference number (
) of 0.67, a highly stable sodium plating‐stripping behaviour and a low overpotential of ≈190 mV. This study establishes a new paradigm for developing SPEs by engineering multifunctional polymers. The self‐reporting and biodegradable properties would greatly expand the scope of applications for SPEs.
A Catalytic Method to Activate Nitromethane by the Cooperation of Homo‐ and Heterogeneous Catalysis
Authors: Wang Weijin , Liu Jianzhong , Yang Licheng , Song Song , Jiao Ning 
Published: December 2023

AbstractThe achievement of directly activating and utilizing bulk small molecules has remained a longstanding objective in the field of chemical synthesis. The present work reports a catalytic activation method for bulk chemical nitromethane (MeNO2). This method combines homogeneous Lewis acid with recyclable heterogeneous Brønsted acid catalysis, featuring practicality, sustainability, and low cost, thus solving the inherent drawbacks of previous Nef processes where stoichiometric reductants or activators were required. By combining the advantages of both homo‐ and heterogeneous catalysts, this chemistry may not only offer new opportunities for the further development of MeNO2 as a nitrogen source for organic synthesis, but also promote the catalysis design in synthetic chemistry.
Structural Element of Vitamin U‐Mimicking Antibacterial Polypeptide with Ultrahigh Selectivity for Effectively Treating MRSA Infections
Authors: Zhang Zhenyan , Wang Xiaodan , Liu Jiaying , Yang Huawei , Tang Haoyu , Li Jing , Luan Shifang , Yin Jinghua , Wang Lei , Shi Hengchong 
Published: December 2023

AbstractAntimicrobial peptides (AMPs) exhibit mighty antibacterial properties without inducing drug resistance. Achieving much higher selectivity of AMPs towards bacteria and normal cells has always been a continuous goal to be pursued. Herein, a series of sulfonium‐based polypeptides with different degrees of branching and polymerization were synthesized by mimicking the structure of vitamin U. The polypeptide, G2‐PM‐1H+, shows both potent antibacterial activity and the highest selectivity index of 16000 among the reported AMPs or peptoids (e.g., the known index of 9600 for recorded peptoid in “Angew. Chem. Int. Ed., 2020, 59, 6412.”), which can be attributed to the high positive charge density of sulfonium and the regulation of hydrophobic chains in the structure. The antibacterial mechanisms of G2‐PM‐1H+ are primarily ascribed to the interaction with the membrane, production of reactive oxygen species (ROS), and disfunction of ribosomes. Meanwhile, altering the degree of alkylation leads to selective antibacteria against either gram‐positive or gram‐negative bacteria in a mixed‐bacteria model. Additionally, both in vitro and in vivo experiments demonstrated that G2‐PM‐1H+ exhibited superior efficacy against methicillin‐resistant Staphylococcus aureus (MRSA) compared to vancomycin. Together, these results show that G2‐PM‐1H+ possesses high biocompatibility and is a potential pharmaceutical candidate in combating bacteria significantly threatening human health.
Voice, capacity, awareness: Early career ocean professionals’ perspectives on the equitable implementation of the Biodiversity Beyond National Jurisdiction Agreement
Authors: Caldeira Mariana , Ferreira Lopes Vanessa 
Published: December 2023

Abstract

The urgent need for the conservation and sustainable use of the ocean has come into focus as an international concern over the last decade, prompting negotiations for a new legally binding instrument under the UN Convention on the Law of the Sea to conserve and sustainably use marine biodiversity of areas beyond national jurisdiction: the Biodiversity Beyond National Jurisdiction (BBNJ) Agreement. After almost 15 years of debate, the BBNJ Agreement was concluded in March 2023.
This paper is an opinion piece that showcases our perspectives as two early career ocean professionals from developing countries (Brazil and Cabo Verde) who participated as observers in the Fifth Intergovernmental Conference for the development of the BBNJ Agreement, held in 2022 and 2023. We identified factors that affected the equitable participation of professionals from developing countries in the BBNJ Agreement process. We offer our reflections on the underrepresentation of some countries in negotiations, as well as in science, and the factors hindering capacity to express their own needs and concerns.
We present three suggestions for creating more equitable participation of countries in such negotiations and enabling the future implementation of the BBNJ Agreement by developing countries: (1) Increase professional opportunities and develop capacity of early researchers from developing countries; (2) fair participation in implementation of BBNJ Agreement; and (3) enabling capacity in developing countries to be sustained in the long term.
Association of Combined Anti‐Ro52/TRIM21 and Anti‐Ro60/SSA Antibodies With Increased Sjögren Disease Severity Through Interferon Pathway Activation
Authors: Bettacchioli Eléonore , Saraux Alain , Tison Alice , Cornec Divi , Dueymes Maryvonne , Foulquier Nathan , Hillion Sophie , Roguedas‐Contios Anne‐Marie , Benyoussef Anas‐Alexis , Alarcon‐Riquelme Marta E. , Pers Jacques‐Olivier , Devauchelle‐Pensec Valérie ,   PRECISESADS Clinical Consortium, and PRECISESADS Sjögren Consortium
Published: December 2023

ObjectiveThe biologic diagnosis of primary Sjögren disease (SjD) mainly relies on anti‐Ro60/SSA antibodies, whereas the significance of anti‐Ro52/TRIM21 antibodies currently remains unclear. The aim of this study was to characterize the clinical, serological, biologic, transcriptomic, and interferon profiles of patients with SjD according to their anti‐Ro52/TRIM21 antibody status.MethodsPatients with SjD from the European PRECISESADS (n = 376) and the Brittany Diagnostic Suspicion of primitive Sjögren's Syndrome (DIApSS); (n = 146) cohorts were divided into four groups: double negative (Ro52−/Ro60−), isolated anti‐Ro52/TRIM21 positive (Ro52+), isolated anti‐Ro60/SSA positive (Ro60+), and double‐positive (Ro52+/Ro60+) patients. Clinical information; EULAR Sjögren Syndrome Disease Activity Index, a score representing systemic activity; and biologic markers associated with disease severity were evaluated. Transcriptome data obtained from whole blood by RNA sequencing and type I and II interferon signatures were analyzed for PRECISESADS patients.ResultsIn the DIApSS cohort, Ro52+/Ro60+ patients showed significantly more parotidomegaly (33.3% vs 0%–11%) along with higher β2‐microglobulin (P = 0.0002), total immunoglobulin (P < 0.0001), and erythrocyte sedimentation rate levels (P = 0.002) as well as rheumatoid factor (RF) positivity (66.2% vs 20.8%–25%) compared to other groups. The PRECISESADS cohort corroborated these observations, with increased arthritis (P = 0.046), inflammation (P = 0.005), hypergammaglobulinemia (P < 0.0001), positive RF (P < 0.0001), leukopenia (P = 0.004), and lymphopenia (P = 0.009) in Ro52+/Ro60+ patients. Cumulative EULAR Sjögren Syndrome Disease Activity Index results further confirmed these disparities (P = 0.002). Transcriptome analysis linked anti‐Ro52/TRIM21 antibody positivity to interferon pathway activation as an underlying cause for these clinical correlations.ConclusionThese results suggest that the combination of anti‐Ro52/TRIM21 and anti‐Ro60/SSA antibodies is associated with a clinical, biologic, and transcriptional profile linked to greater disease severity in SjD through the potentiation of the interferon pathway activation by anti‐Ro52/TRIM21 antibodies.image
Synthesis of Boronic Esters from Organometallic Reagents and Bis(pinacolato)diboron
Authors: Paul Swagata , Panda Santanu 
Published: December 2023

AbstractSynthesis of alkyl, aryl, and vinyl boronic esters carrying various chiral and achiral diol‐protecting groups were synthesized starting from the corresponding alkyl, aryl, and vinyl lithium or Grignard reagents. Good to excellent yields were obtained for a large range of substrates. The reaction can be conducted in a gram scale to obtain the product over 80 % yield. This approach provides direct access to neopentyl, pinene, and other boronic esters that are difficult to achieve. Using trimethoxyborane or 2‐isopropoxy pinacolboronic ester. Detailed mechanistic studies have been conducted to understand the mechanism behind the formation of boronic ester starting from organometallic reagents.
Associations of unintended pregnancy with autism spectrum disorders and the modification of folic acid supplements
Authors: Chen Qian , Liu Xing‐Lian , Lin Li‐zi , Wang Xin , Li Ming‐Hui , Dai Mei‐Xia , Cao Mu‐Qing , Li Xiu‐Hong , Jin Jing , Xu Hai‐Qing , Cai Li 
Published: December 2023

AbstractThere is limited evidence on the associations of unintended pregnancy with autism spectrum disorders (ASD). This study aimed to examine this relationship and the modification of pre‐conceptional and prenatal folic acid supplements. Six thousand and five toddlers aged 16 to 30 months from seven cities of six provinces in China were eligible for participation. Information on unintended pregnancy and folic acid supplements was obtained via questionnaires from caregivers of toddlers. The diagnosis of ASD was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5) and the Chinese version of the Childhood Autism Rating Scale (CARS). Of the 6005 toddlers in the study (3337 boys and 2668 girls), 71 (1.18%) received the diagnosis of ASD. Generalized linear models with a logit link function showed unintended pregnancy was positively associated with ASD (odds ratios [OR] = 1.69, 95% confidence interval [CI], 1.05–2.79). Stratified estimates indicated that the association remained stable among toddlers of mothers without pre‐conceptional and prenatal folic acid supplements (OR = 2.75, 95% CI, 1.04–7.27; n = 1243, 20.70%). Unintended pregnancy was associated with higher odds of ASD in 16–30 months of toddlers, and the association was consistent among toddlers of mothers without prenatal folic acid supplements. Our findings emphasize the need to raise awareness of the risk of unintended pregnancy and the benefits of folic acid supplements among Chinese women.
Crystal, Solution, and Computational Study of the Structure of Ortho‐Lithium N,N‐Diisopropyl‐P,P‐Diphenylphosphinothioic Amide
Authors: Belmonte‐Sánchez Eva , García‐López Jesús , Navarro Yolanda , Iglesias María José , Fernández Ignacio , López‐Ortiz Fernando 
Published: December 2023

AbstractThe first crystal structure of an ortho‐lithium phosphinothioic amide complexed with tetramethylethylenediamine 12 is reported. The complex consists of a spirane in which the spiro‐lithium is N,N‐ and C,S‐chelated by the diamine and organophosphorus ligands, respectively. The analogous ortho anion 14 obtained by Sn(IV)/Li transmetallation in THF has also been synthesized. Nuclear magnetic resonance study of both anions showed that they exist as monomers in solution and are involved in dynamic processes including the restricted rotation around the P−N bond. 14 is converted at room temperature by nucleophilic cyclization to the dearomatized anion 15, which evolves after a few hours to the benzophosphindole sulfide 16. Density functional theory calculations supported the aggregation state in solution and were used to explore the conformational space of anion 12, the mechanism of ortho‐lithiation directed by P(X)−N (X=O, S) groups, and the mechanism of formation of 15.
Stable organic polymer anode for high rate and fast charge sodium based dual‐ion battery
Authors: Liu Xuan , Wu Hongzheng , Xuan Zipei , Li Li , Fang Yaobing , Yuan Wenhui 
Published: December 2023

AbstractConsidering the extensive resources, flexible structural designability, and abundant active sites, organic electrodes have been considered as the ideal sodium storage materials. However, organic materials generally face the limitations of unstable and dissolved characteristic, leading to a poor cyclic stability. In this work, we proposed a carbon nanotube (CNT) modified polyimide as the anode for sodium‐based dual‐ion battery (SDIB). The polyimide remains well the structure and morphology of monomer with a stable conjugated structure and high degree of crystallinity, effectively enhancing the electrochemical performance of the SDIBs. Also, the cooperation with CNT particularly improves the ion conductivity of the anode and advances the rate performance. Combined with an ionic liquid electrolyte, the constructed dual‐ion battery exhibits excellent rate capability, high specific discharge capacity and stable cycling performance. It delivers a specific discharge capacity of 119.3 mA h g−1 at 0.2 C (1 C=100 mA g−1) and still has a specific discharge capacity of 82.3 mA h g−1 even after 1000 cycles at 10 C. Besides, the system displays a low self‐discharge rate and stable fast charging performance, which is expected to be applied in the large‐scale electrochemical energy storage devices and inspire the future development of SDIBs.
Efficient capture and separation of CO2‐Boosted carbon neutralization enabled by tailorable metal‐organic frameworks: A review
Authors: Zhang Hao , Zhou Zihui , Yin Yanan , Xu Hong , Wang Yimeng , Yang Kai , Zhang Zhijun , Wang Jianlong , He Xiangming 
Published: December 2023

AbstractThe long‐term development of fossil energy has led to the destruction of carbon balance. Carbon capture technology needs to be used to reduce carbon emissions before clean energy completely replaces fossil energy. Metal‐organic frameworks (MOFs), a porous crystalline material, show great potential in gas adsorption and has attracted great attention. The predictability of MOFs' structure and function also make it possible to use computational methods to advance and accelerate research. This review gives a brief overview of carbon dioxide capture and separation by MOFs, including adsorption and membrane separation. In the future, membrane separation technology is expected to be a crucial area of research for carbon capture applications due to its favorable characteristics such as high treatment efficiency and low carbon footprint, while mixed matrix membranes (MMMs) have been given more attention by scholars due to their lower cost and better separation performance. In summary, developing high‐performance MOFs or MOF derivatives and researching more efficient separation methods, such as the application of MOF‐based MMMs, should be the focus of future research by scholars in this field.
Musculoskeletal co‐morbidities in patients with transthyretin amyloid cardiomyopathy: a systematic review
Authors: Formiga Francesc , Baeza Laia Saumell , Chivite David , Yun Sergi 
Published: December 2023

AbstractThe prevalence of transthyretin‐associated amyloidosis cardiomyopathy (ATTR‐CM) has grown because of newer non‐invasive diagnosis tools. Detecting the presence of extra‐cardiac ATTR manifestations such as musculoskeletal pathologies considered ‘red flags’, when there is minimal or non‐cardiac clinical involvement is primordial to carry out an early diagnosis. The aim of this systematic review is to examine the prevalence of musculoskeletal, ATTR‐deposition‐related co‐morbidities in patients already diagnosed with ATTR‐CM, specifically carpal tunnel syndrome, ruptured biceps tendon, spinal stenosis, and trigger finger. We performed a systematic review using PRISMA guidelines. Inclusion criteria were all studies in English and Spanish language and participants had to be patients diagnosed with ATTR‐CM, by any diagnostic method, with the musculoskeletal co‐morbidities subject of this review. The quality of the studies was based on the Risk of Bias Tool. This systematic review included 22 studies for final analysis. Carpal tunnel syndrome is reported in 21 studies, brachial biceps tendon rupture is reported in three, and spinal stenosis in eight studies. No articles that accomplished all the inclusion criteria for trigger finger were found. Regarding to the quality of the studies, all of them were categorized as being of high and moderate quality. The frequent association between ATTR‐CM and carpal tunnel syndrome, ruptured biceps tendon, and lumbar spinal is confirmed, and the onset of these co‐morbidities usually precedes the diagnosis of by years. This association defines them as red flags that should be search proactively due to the current treatment possibilities and the severity of the presentation of cardiac amyloidosis.