bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gestión de residuos sólidos en cadenas de suministro de ciclo cerrado desde la perspectiva de la investigación de operaciones
Authors: Peña Montoya Claudia Cecilia , Osorio Gómez Juan Carlos , Vidal Holguín Carlos Julio , Torres Lozada Patricia , Marmolejo Rebellón Luis Fernando 
Published: November 2023

La integración de los flujos reversos y directos en la cadena de suministro, trae beneficios al reducir costos y evitar el daño ambiental porque se recupera valor de los residuos sólidos; esta integración se conoce como la cadena de suministro de ciclo cerrado. La mayoría de experiencias que relacionan cadena de suministro de ciclo cerrado y decisiones de gestión de residuos sólidos, provienen de países desarrollados con estrictas regulaciones ambientales y usan técnicas de invetigación de operaciones. El objetivo se este artículo es identificar la factibilidad de aplicar técnicas de investigación de operaciones a las decisiones de gestión de residuos sólidos en las cadena de suministro de ciclo cerrado en países en desarrollo como Colombia. Se identificaron variables importantes de los articulos revisados tales como los diferentes tipos de residuos, las regiones y el uso de técnicas de optmización, simulación y multicriterio. La metodología de vigilancia tecnológica se uso para correlacionar estas variables. Los resultados mostraron que la técnica de multicriterio es usada con más frecuencia porque permite la consideración de varios aspectos en una misma decisión; por lo tanto, el uso de esta técnica sería conveniente para enfrentar efectivamente las principales decisiones en las incipientes cadenas de suministro de ciclo cerrado en países en desarrollo.
La alfabetización ecológica como nueva pedagogía para la comprensión de los seres vivientes
Authors: Aranda Sánchez José M. 
Published: November 2023

El objetivo central de este artículo es analizar las bases, la plataforma y los principios de la pedagogía que Fritjof Capra ha denominado Alfabetización Ecológica, para referirse a una particular forma de abordar la educación ambiental, ya no desde el salón de clases sino a partir del lugar mismo donde se busca intervenir, teniendo como soporte filosófico-científico a la Ecología Profunda; y con una vasta experiencia de trabajo colectivo que ha rebasado fronteras geográficas, y no exige más doctrina que la voluntad y humildad para seguir los pasos que permitan descubrir los problemas y actuar en consecuencia, en el aquí y ahora de nuestras complejas relaciones comunitarias con los sistemas vivientes.
Bracing with Tape and Extensor Refixation of Elbow with Posterolateral Instability Due to Cubitus Varus
Authors: Sachinis Nikolaos Platon , Beitzel Knut , Moya Daniel , Gomez Diego , Koukos Christos 
Published: November 2023

Case:
A 54-year-old patient had lateral ligament insufficiency due to cubitus varus from a childhood supracondylar fracture. Arthrolysis/synovectomy and at a later stage double-row extensor origin refixation and lateral ulnar collateral ligament bracing with nonabsorbent tape and anchors were performed. Follow-up at 3, 6, 12, and 24 months showed excellent Mayo Elbow Performance and Disabilities of Arm, Shoulder, and Hand Scores (24-month follow-up = 100 and 2.5, respectively).

Conclusion:
Suture tape augmentation and double-row extensor refixation in cases of lateral collateral ligament complex insufficiency due to cubitus varus may provide improved short-term functional outcomes, from the third postoperative month.
Una reforma procesal de calado en materia de reclamaciones derivadas de actos anticoncurrenciales
Authors: Cohen Benchetrit Amanda 
Published: November 2023

Por medio del Real Decreto-Ley 9/2017, de 26 de mayo (BOE 27 de mayo de 2017) se ha llevado a cabo en nuestro país la implementación, entre otras, de la Directiva 2014/104/UE (comúnmente conocida como la “Directiva de daños” -en adelante, la Directiva). La convalidación de este Real Decreto- Ley se acordó por el Congreso de los Diputados en su Resolución de 22 de junio de este año (BOE 30 de junio de 2017).
La figura del administrador de hecho y su incidencia en sede concursal
Authors: Armijo Pliego Ana 
Published: November 2023

El artículo 133 de la LSA (Ley 26/2003, de 17 de julio) introdujo en nuestro ordenamiento jurídico la figura del administrador de hecho al regular –por primera vez- un régimen de responsabilidad para quienes ejercitan el facultadas de gestión y control sin ostentar formalmente el cargo de administrador social, actuaran como tal; si bien, el texto legal no introdujo una definición de dicho concepto.
El delito de administración desleal. Los administradores societarios como sujetos activos del mismo y su relación con los deberes de diligencia y lealtad.
Authors: Jiménez Crespo Luis Miguel 
Published: November 2023

Este artículo tiene como objeto llevar a cabo una breve exposición sobre la relación existente entre el nuevo tipo penal de administración desleal contenido en el art. 252 del Código Penal en la redacción dada al mismo la Ley Orgánica 1/2015, de 30 de marzo que entró en vigor el 1 de julio de 2015 y la posibilidad de que los administradores societarios sean sujetos activos del mismo por infracción de los deberes de diligencia y lealtad tal y como han quedado definidos en la Ley de Sociedades de Capital (LSC) tras la reforma operada por la Ley 31/2014, de 3 de diciembre por la que se modifica esta ley para la mejora del gobierno corporativo
IMPACTO DE LA LEY DE APOYO A LOS EMPRENDEDORES Y A SU INTERNACIONALIZACIÓN. NUEVOS CRITERIOS DE APLICACIÓN.
Authors: Ortega Giménez Alfonso , Castellanos Cabezuelo Ángela 
Published: November 2023

Hasta nueve Ministerios participan en la elaboración de uno de los proyectoslegislativos más emblemáticos del Gobierno del Presidente Rajoy (la Ley 14/2013, de 27 de septiembre, de apoyo a los Emprendedores y su Internacionalización) que revisa toda la normativa relativa al empleo y al emprendedurismo y afecta tanto al diseño de las materias en la Educación Primaria como a la política de concesión de visados de residencia del Gobierno.El conjunto de medidas que prevé la Ley pretende, entre otros, atraer inversores, emprendedores, trabajadores que efectúen movimientos intraempresariales, profesionales altamente cualificados e investigadores. Las medidas implementadas en la Ley, en definitiva, permitirán aumentar la competitividad de la economía de nuestro país, puesto que incentivará la internacionalización de las empresas. Este articulo pretende, de una forma sencilla, ágil y con un enfoque práctico, analizar los nuevos criterios de aplicación de la Ley 14/2013, de 27 de septiembre, de Apoyo a los Emprendedores y su Internacionalización [Ley 14/2013, de 27 de septiembre, de apoyo a los emprendedores y su internacionalización (BOE núm. 233, de 28 de septiembre de 2013)].
Bile acids enrichment supports tumor aerobic glycolysis and
establishes immunosuppressive microenvironment
Authors: Zhang Zongde , Jiang Hongyu , Li Xingjie , Tan Jinzhuo , Wu Renlan 
Published: November 2023

Abstract
Fast-growing solid tumors employ aerobic glycolysis to meet the demand balance of energy and anabolic growth and promote tumor immune evasion. The tumor microenvironment (TME) factors that support aerobic glycolysis have not been determined. Here, we show that microbiota-metabolized bile acids (BA) were highly enriched in melanoma and breast cancer. Depletion of bile acids suppresses tumor progression, increases T cell infiltration, and alleviates T cell exhaustion. Transcriptome analysis reveals that a lack of bile acid improves the expression of oxidative phosphorylation genes in vivo. Bile acids enrichment supports aerobic glycolysis via FXR-RARα interaction. Depletion of BA impairs the tumor's immune suppressive barrier and reduces the protein levels of FXR and RARα. Our study unveils that a
mechanism of tumor progression modulated BA-RA signaling by
FXR-RARα interaction and bile acid as a latent target, which suggests a possible way for tumor diagnosis and treatments.
Physical and Chemical Properties of New Carambola Variety Bintang Mas at Three Different Maturity Stages
Authors: Shapawi Zahrah-Izati Azhar , Ariffin Siti Hajar , Shamsudin Rosnah , How Syahmeer , Baharom Ahmad Hafiz 
Published: November 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
The central role of cancer driver genes in pathway networks according to persistence homology
Authors: Ramos Rodrigo Henrique , Bardelotte Yago Augusto , Ferreira Cynthia de Oliveira Lage , Simao Adenilso 
Published: November 2023

Abstract
Cancer is a complex disease caused by mutations accumulated over a lifetime. Albeit cancer cells harbor many mutations, only a small fraction, called driver mutations, are responsible for the emergence and maintenance of the disease. Pathway networks are subsets from the whole cell interactome and represent meaningful biological functions. In this study, we explore the topological complexity of pathway sub-networks using the persistence homology theory, observing driver genes’ role. Results show drivers are associated with higher-order structures, and their removal is more impactful than non-drivers in the network complexity, even when the non-drivers are hubs. These findings increase our understanding of drivers and place persistent homology as an approach that can extract characteristics beyond traditional centrality measures that can be used to discover new driver genes.
ADMM-TGV image restoration for scientific applications with unbiased parameter choice
Authors: Zietlow Christian , Lindner Jörg K. N. 
Published: November 2023

Abstract
Image restoration via Alternating Direction Method of Multipliers (ADMM) has gained large interest within the last decade. Solving standard problems of Gaussian and Poisson noise, the set of ‘Total Variation’ (TV) based regularizers proved to be efficient and versatile. In the last few years the ‘Total Generalized Variation’ (TGV) approach combined TV regularizers of different orders adaptively to better suit local regions in the image. This improved the technique significantly. The approach solved the staircase problem inherent of the first order TV while keeping the beneficial edge preservation. The iterative minimization for the augmented Lagrangian of TGV problems requires four important parameters, two penalty parameters ρ and η and two regularization parameters λ0 and λ1. The choice of penalty parameters decides on the convergence speed, the regularization parameters decide on the impact of the respective regularizer and are determined by the noise level in the image. For scientific applications of such algorithms, an automated and thus objective method to determine these parameters is essential to receive unbiased results independent of the user. Obviously, both sets of parameters are to be well-chosen to achieve optimal results, too. In this paper a method is proposed to adaptively chose optimal ρ and η values for the iteration to converge faster, based on the primal and dual residuals arising from the opti-mality conditions of the augmented Lagrangian. Further, we show how to choose λ0 and λ1 based on the inherent noise in the image.
Electropolymerized polyaniline on electrospun silica nanofibers to prepare a SPME fiber for the sampling of linear alkyl benzenes
Authors: Rashidipour Marzieh , Dalvand Kolsoum , Ghiasvand Alireza 
Published: November 2023

Abstract
A polyaniline/silica (PANI/SiO2) nanocomposite was electrodeposited on the surface of a stainless steel wire and applied for the extraction of linear alkyl benzenes (LABs) with headspace solid-phase microextraction (HS-SPME) method followed by GC-FID quantification. The structure and morphology of the synthesized sorbent was characterized using scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FT-IR) techniques. Response surface methodology (RSM) involving central composite design (CCD) was employed to evaluate the important experimental variables. Under the optimal conditions, linear dynamic ranges (LDRs) were in the range of 0.05-12µg mL− 1 for Φ-C11 and Φ-C13, 0.02-12µg mL− 1 for Φ-C12 and Φ-C14 with acceptable linearity greater than 0.99. The limits of detection (LODs) were found to be 0.4–0.9 ng mL− 1. The developed HS-SPME-GC-FID method was successfully applied for the extraction and determination of LABs in water and wastewater samples.
Combinatorial summation of Feynman diagrams: Equation of state of the 2D SU(N) Hubbard model
Authors: Kozik Evgeny 
Published: November 2023

Abstract

Feynman's diagrammatic series is a common language for a formally exact theoretical description of systems of infinitely-many interacting quantum particles, as well as a foundation for precision computational techniques. Here we introduce a universal framework for efficient summation of connected or skeleton Feynman diagrams for generic quantum many-body systems. It is based on an explicit combinatorial construction of the sum of the integrands by dynamic programming, at a computational cost that can be made only exponential in the diagram order on a classical computer and potentially polynomial on a quantum computer. We illustrate the technique by an unbiased diagrammatic Monte Carlo calculation of the equation of state of the 2D SU(N) Hubbard model in an experimentally relevant regime, which has remained challenging for state-of-the-art numerical methods.
Cactodera guizhouensis n. sp. (Nematoda: Heteroderinae), a new species of cyst-forming nematode from roots and surrounding soil of potato in Guizhou, China
Authors: ni Chunhui , Xie Yujia , Yang Si-Hua , Yang Zai-Fu , Xu Chunling , Xie Hui 
Published: November 2023

Abstract
A new cyst-forming nematode, Cactodera guizhouensis n. sp., isolated from roots and surrounding soil of potato in Guizhou, China, was the first species of genus Cactodera found from the potato rhizosphere. The new species was characterized by its L/W ratio of cyst is 1.4±0.1 (1.3-1.8), while fenestral diam. is 17.7-28.7×12.3-23.4 μm and absent vulval denticlest; its stylet length of second stage juveniles is 26.5±1.2 (24.1-29.0) μm, while tail is 53.4±3.9 (45.0-61.9) μm and hyaline tail is 25.7±2.4 (21.6-29.8) μm, as well as lateral field with four incisures and areolation; its eggshell with punctations. The internal transcribed spacer sequences of ribosomal RNA (ITS-rRNA), the sequences of the D2-D3 region of 28S ribosomal RNA (28S-rRNA) from the new species were amplified and sequenced. The phylogenetic tree based on sequences of ITS-rRNA and 28S-rRNA D2-D3 region showed that the new species clustered into a separate clade and could be distinguished from other species in genus Cactodera. A key to the species of Cactodera is also provided in this study.
Human amniotic membrane vs. silver sulfadiazine dressing in second-degree burns: a randomized controlled clinical trial
Authors: Moghimi Mohammad Hossein , Salehiyan Mehran , Abdi Mohammad , Tahrekhani Mehran , Safaie Alireza , Kamali Koorosh 
Published: November 2023

Abstract

Background
Burn wounds require optimal medical management due to associated psycho-emotional and socioeconomic impacts, and severe pain. Utilizing synthetic and biological dressings improves healing and reduces burn wound complications. The present study aimed to compare the outcomes of using a human amniotic membrane (HAM) and conventional silver sulfadiazine (SSDZ) ointment as the dressings, in the management of the second-degree burn wound,2018, Zanjan, Iran.
Methods
Fifty patients participated in this clinical trial and were divided into two groups by simple randomization. The target group (n = 25) was treated with HAM, and the control group (n = 25) was treated with the SSDZ ointment. The researcher-designed checklist was used to determine the clinical performance in the follow-up assessments on days 7, 14, and 30.
Results
No significant difference was found in terms of gender, age, and the percentage of the burn wound (P > 0.05). Wound epithelialization (days 7,14, and 30), scar and pigmentation of the wound, pain severity, the amount of analgesia required, and the hospital stay length (on day 30) were significantly less in the target group, compared to the control (P < 0.05). Nonetheless, the treatment costs in the target group (170$) were significantly higher than in the control (71$) (P < 0.001).
Conclusion
The HAM as a technology-based therapy dressing, albeit expensive, is superior to the SSDZ ointment dressing in terms of wound healing and pain mitigation. Due to the efficiency of this novel product educational policies are recommended to implement technological therapy modules in the medical education curriculum.
Deep longitudinal lower respiratory tract microbiome profiling reveals genome-resolved functional and evolutionary dynamics in critical illness
Authors: Jiang Chao , Cheng Minghui , Xu Yingjie , Cui Xiao , Wei Xin , Chang Yundi , Xu Jun , Lei Cheng , Xue Lei , Wang Zhang , Huang Lingtong , Zheng Min , Luo Hong , Leng Yuxin 
Published: November 2023

Abstract
The lower respiratory tract (LRT) microbiome impacts human health, especially among critically ill patients. However, comprehensive characterizations of the LRT microbiome remain challenging. We developed an efficient chelex100-based low-biomass microbial-enrichment method (CMEM) that enables the efficient deep metagenomic profiling of LRT samples to recover near-complete microbial genomes. We applied the method to 465 longitudinally collected LRT samples from 157 patients in intensive care units (ICUs) in three geographically distant hospitals. We detected hospital-specific and longitudinal signatures of the microbiome. Integrative analysis with clinical data demonstrated that diagnosed pneumonia and the length of ICU stay were significantly correlated with the abundance of specific microbes and antibiotic-resistance genes (ARGs). Importantly, the alpha diversity of the LRT microbiome is inversely correlated to ARG abundance. Moreover, CMEM opens new avenues for genome-resolved analyses without laborious culturing. MAG-based analyses reveal strain-specific resistome and virulome and frequent inter-patient transmissions in ICUs. Evolutionary analyses identified highly conserved plasmids and recombination hotspots in Acinetobacter baumannii and Klebsiella pneumoniae, which are associated with conjugative elements and prophages. Collectively, we present a genome-resolved functional, transmission, and evolutionary landscape of the longitudinal LRT microbiota in critically ill patients, demonstrating the deep LRT microbiome profiling method as a powerful tool for LRT microbial surveillance, functional, evolutionary, and clinical research.
Association between total testosterone and cervical cancer: A bidirectional Mendelian randomization study
Authors: Lyu Qiongying , Zhang Juan , He Xiaoyan , Chen Yurou , Fan Guanlan , Xiong Jiaqiang , Zhang Wei 
Published: November 2023

Abstract
Background
Several experimental studies already proved that the increase of total testosterone could lead to the development of gynecological disease. Animal experiments have shown that testosterone may be associated with the progression of cervical cancer (CC). And the metabolism of cholesterol which serves as the initial raw material for testosterone synthesis is crucial for the occurrence of CC. However, the causal relationship between CC and Total testosterone still remained unknown.
Methods
We performed bidirectional Mendelian randomization (MR) study using summary statistics from the genome-wide association studies (GWAS) of Total testosterone and CC. Single nucleotide polymorphisms (SNPs) were used as instrumental variables (IVs) from GWAS in this study. The random-effects inverse-variance weighted (IVW) estimation method was applied as the primary method with several other estimators as complementary methods. Total testosterone was seen as exposure in forward MR analysis and CC was utilized as exposure in reverse MR analysis, and their SNPs were read and screened by "TwoSampleMR" R package. The bidirectional MR results were verified by a series of sensitive analyses. Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of genes regulated by instrumental variable SNPs were conducted using “cluster Profiler”.
Results
In our study, the inverse-variance weighted (IVW) analysis in forward MR analysis (OR:1.0016, 95% confidence interval [CI]: 1.0005–1.0027; p < 0.05) clarified that these SNPs could effectively predict that total testosterone could lead to increases the risk of CC, indicating a direct effect of total testosterone on CC. The IVW analysis in reverse MR analysis did not find a significant effect of CC on Total testosterone (p = 0.557). Moreover, in forward MR, most genes regulated by instrumental variable SNPs are mainly involved in C21-steroid hormone metabolic process, MHC protein complex and progesterone metabolic process, and the signal pathways are mainly involved in Th1 and Th2 cell differentiation, Hematopoietic cell lineage, Th17 cell differentiation.
Conclusion
The present study strengthened the evidence that Total testosterone is a potential risk factor for CC. Whether CC affects Total testosterone needs further research.
An Optimal Navigation Model for Realistic Traffic Network Scenarios in VANET
Authors: Kumari J Jesy Janet , S Thangam , Raja A. Saleem 
Published: November 2023

Abstract
Vehicle Ad-hoc Networks (VANETs) are a kind of Internet of Things system where groups of vehicles connect and vehicle tracking infrastructure to enhance driver and public security as well as lifestyles. In a VANET, vehicles oversee the communicating status to the controller and other drivers for processing, as well as the statuses of the road, traffic, and atmosphere around them. In these actual VANET network traffic scenarios, this research presents the mixing of enhanced genetic algorithms (EGA) based on ant colony optimization (ACO) techniques (EGAACO) to create an optimized routing algorithm. This research evaluates the conventional algorithm with metaheuristic possibilities and includes the experimental VANET simulation scenario. To verify the outcomes, the proposed approach is tested using open-source network and traffic simulation tools. On Simulation of Urban Mobility (SUMO), all three different traffic scenarios were simulated and examined using NS3.2. The results of these analyses were satisfactory, and it emerged EGAACO algorithm, performed better than the others in each of the three traffic scenarios. The four real-time traffic network scenarios include average throughput, packet delivery ratio, end-to-end delay, and packet loss in a network, which is collected from the city of Bangalore, and the performance metric measures utilized in traffic network conditions. The experimental result proved that the proposed EGAACO algorithm outperforms the Ad-hoc on- Demand Distance Vector Routing (AODV), Particle Swarm Intelligence (PSO), and ACO routing protocols in all settings.