bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevation of inositol pyrophosphate IP7 in the mammalian spinal cord of amyotrophic lateral sclerosis
Authors: Ito Masatoshi , Fujii Natsuko , Kohara Saori , Tanaka Masayuki , Takao Masaki , Mihara Ban , Saito Yuko , Mizuma Atsushi , Nakayama Taira , Netsu Shizuka , Suzuki Naoto , Kakita Akiyoshi , Nagata Eiichiro 
Published: January 2024

BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive impairment of spinal motor neurons. Continuous research endeavor is underway to fully understand the molecular mechanisms associating with this disorder. Although several studies have implied the involvement of inositol pyrophosphate IP7 in ALS, there is no direct experimental evidence proving this notion. In this study, we analyzed inositol pyrophosphate IP7 and its precursor IP6 in the mouse and human ALS biological samples to directly assess whether IP7 level and/or its metabolism are altered in ALS disease state.MethodsWe used a liquid chromatography-mass spectrometry (LC-MS) protocol originally-designed for mammalian IP6 and IP7 analysis. We measured the abundance of these molecules in the central nervous system (CNS) of ALS mouse model SOD1(G93A) transgenic (TG) mice as well as postmortem spinal cord of ALS patients. Cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMCs) from ALS patients were also analyzed to assess if IP7 status in these biofluids is associated with ALS disease state.ResultsSOD1(G93A) TG mice showed significant increase of IP7 level in the spinal cord compared with control mice at the late stage of disease progression, while its level in cerebrum and cerebellum remains constant. We also observed significantly elevated IP7 level and its product-to-precursor ratio (IP7/IP6) in the postmortem spinal cord of ALS patients, suggesting enhanced enzymatic activity of IP7-synthesizing kinases in the human ALS spinal cord. In contrast, human CSF did not contain detectable level of IP6 and IP7, and neither the IP7 level nor the IP7/IP6 ratio in human PBMCs differentiated ALS patients from age-matched healthy individuals.ConclusionBy directly analyzing IP7 in the CNS of ALS mice and humans, the findings of this study provide direct evidence that IP7 level and/or the enzymatic activity of IP7-generating kinases IP6Ks are elevated in ALS spinal cord. On the other hand, this study also showed that IP7 is not suitable for biofluid-based ALS diagnosis. Further investigation is required to elucidate a role of IP7 in ALS pathology and utilize IP7 metabolism on the diagnostic application of ALS.
A comparative analysis of radical cystectomy with perioperative chemotherapy, chemoradiation therapy, or systemic therapy in patients with clinically advanced node-positive bladder cancer (cN2/N3)
Authors: Garg Harshit , Bhandari Mukund , Dursun Furkan , Liss Michael A. , Kaushik Dharam , Svatek Robert S. , Mansour Ahmed M. 
Published: January 2024

IntroductionThe management of non-metastatic clinically advanced lymph nodal (cN2/N3) bladder cancer (Stage IIIB) could involve radical cystectomy, chemoradiation, or systemic therapy alone. However, a definitive comparison between these approaches is lacking. This study aims to compare the outcomes of patients undergoing radical cystectomy with pelvic lymph node dissection (RC-PLND), chemoradiation therapy (CRT) or systemic therapy (including immunotherapy) (ST) only in patients with stage IIIB bladder cancer.Materials and methodsA retrospective analysis of the National Cancer Database for patients with stage IIIB urothelial bladder cancer was done from 2004-2019. Patients were classified as Group A: Those who received RC-PLND with perioperative chemotherapy, Group B: Those who received CRT, and Group C: Those who received only ST alone. The primary outcome was overall survival (OS). Inverse probability weighting (IPW)-adjusted Kaplan Meier curves were utilized to compare overall survival (OS) and cox multivariate regression analysis was used to identify predictors for OS.ResultsOverall, 2,575 patients were identified. They were classified into Group A (n=1,278), Group B (n=317) and Group C (n=980). Compared to Group B, patients in Group A were younger (SMD=19.6%), had lower comorbidities (SMD=18.2%), had higher income (SMD=31.5%), had private insurance (SMD= 26.7%), were treated at academic centres (SMD=29.3%) and had higher percentage of N2 disease (SMD=31.1%). Using IPW-adjusted survival analysis, compared to Group C, the median OS was significantly higher in Group A (20.7 vs 14.2 months, p&lt;0.001) and Group B (19.7 vs 14.2 months, p&lt;0.001) but similar between Group A and Group B (20.9 vs 19.7 months, p=0.74). Both surgery (HR=0.72 (0.65-0.80), p&lt;0.001) and CRT (0.70 (0.59-0.82), p&lt;0.001) appeared to be independent predictors for OS on cox-regression analysis. The major limitations include bias due to retrospective analysis and non-assessment of cancer-specific survival.ConclusionIn stage IIIB bladder cancer with advanced lymph nodal disease, both RC and CRT offer equivalent survival benefits and are superior to systemic therapy alone.
Abdominal pseudohernia in a child after surgical correction of congenital scoliosis: case report
Authors: Nadirov Nurbek , Vissarionov Sergey , Khusainov Nikita , Filippova Alexandra , Sazonov Vitaliy 
Published: January 2024

Abdominal wall relaxation is a rare complication of various surgical procedures or diseases, when the intercostal or upper lumbar nerves are affected, and the innervation of the muscles of the abdominal wall is damaged. The result is a mass that can visually mimic a ventral hernia. We present a clinical case and the results of a literature review on this topic.Clinical caseThe 2 years 5 months patient diagnosed with a congenital deformity of the spine (posterolateral hemivertebra) underwent extraction of the hemivertebra from the retroperitoneal approach. In the postoperative period, a pseudohernial protrusion of the anterior abdominal wall was observed. 4.5 months later the protrusion resolved spontaneously.DiscussionAbdominal wall relaxation is studied worldwide and is presented primarily as clinical case reports, mainly in older patients with neurological diseases. Single cases of this pathology are described among children. The Th10-Th12 roots are most often affected. Possible manifestations include: bloating and abdominal pain, pseudo-obstruction of the small and/or large intestine, and constipation. In the described case, only unilateral bloating at rest was observed, which increased with crying and strain. The natural course and prognosis of this diagnosis are usually favorable—the recovery period, according to the literature, takes an average of 4–5 months, which also coincided with our case.ConclusionPseudohernias are a rare complication and may can occur during correction of spinal deformities in children. This condition is a transient disorder of the anterior abdominal wall muscles, the cause of which may be neuropathy caused by infection, metabolic disorders, or mechanical damage. The main principles of treatment of this condition include active observation and symptomatic therapy. The prognosis is usually favorable.
Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database
Authors: Zhou Zhi-Peng , Zhong Li , Liu Yan , Yang Zhen-Jia , Huang Jia-Jia , Li Da-Zheng , Chen Yu-Hua , Luan Ying-Yi , Yao Yong-Ming , Wu Ming 
Published: January 2024

Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age &gt;60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p &lt; 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age &gt; 60 years and AKI stage 3.
Correlation analysis between biomechanical characteristics of taekwondo double roundhouse kick and effective scoring of electronic body protector
Authors: Jia Mengyao , Liu Lin , Huang Ruifeng , Ma Yong , Lin Shijie , Peng Qian , Xiong Jun , Wang Zhaoyi , Zheng Weitao 
Published: January 2024

Objective: To explore the inherent relationship between lower limb biomechanical indicators and effective scoring values of double roundhouse kick (DRK) by taekwondo athletes, and to find key biomechanical factors that trigger effective scoring.Methods: Using the DAEDO Protector and Scoring System (PSS) in conjunction with the Vicon optical motion capture system and Kistler 3D force plate, kinematic and dynamic indicators of the front kicking motion were obtained from 12 professional taekwondo athletes (18.00 ± 2.20 years, 182.15 ± 8.62 cm and 70.00 ± 14.82 kg). The correlation between kinematics, dynamics, and scoring values was initially analyzed using bivariate linear correlation. Subsequently, based on the results of the linear correlation analysis, a stepwise regression analysis was performed to establish a stepwise regression equation.Results: The results reveal that during the First Hit, there is a significant positive correlation (r &gt; 0, p &lt; 0.05) between peak hip flexion angular velocity of the dominant leg, knee abduction angle, and peak foot horizontal plane linear velocity of the non-dominant leg with effective score. On the other hand, peak ankle flexion angular velocity of the non-dominant leg, peak foot sagittal plane linear velocity, peak hip abduction angle, and peak hip flexion angle of the dominant leg exhibit a significant negative correlation (r &lt; 0, p &lt; 0.05) with effective score. These correlations hold statistical significance (DW&gt; 1.023). During the Second Hit, there is a significant positive correlation (r &gt; 0, p &lt; 0.05) between peak ankle internal rotation angular velocity of the dominant leg, foot coronal plane linear velocity, hip adduction angular velocity, and peak ankle internal rotation moment of the non-dominant leg with effective score. Conversely, peak hip flexion angle of the dominant leg shows a significant negative correlation (r &lt; 0, p &lt; 0.05) with effective score. All these variables have a statistically significant impact on effective score (DW &gt; 1.023).Conclusion: Explosive power, body posture, adequate terminal velocity, and body rotation have an association with effective scoring of the electronic protector. The peak angular velocity of the ankle joint of the dominant leg and the peak linear velocity of the foot horizontal plane of the non-dominant leg significantly contribute to the effectiveness score of the electronic protector.
Exposure to models’ negative facial expressions whilst eating a vegetable decreases women’s liking of the modelled vegetable, but not their desire to eat
Authors: Edwards Katie L. , Thomas Jason M. , Higgs Suzanne , Blissett Jacqueline 
Published: January 2024

IntroductionFood enjoyment can be conveyed through facial expressions. Observing others’ enjoyment of food has been found to influence adults’ desirability of liked and disliked food. Exposing adults to other eaters enjoying nutritious foods that are typically disliked (e.g., vegetables) could enhance the consumption of vegetables by young adults. However, this remains to be examined in young adult populations. This study examined the effect of models’ facial expressions towards raw broccoli on young adult women’s change in liking and change in desire to eat a modelled vegetable (raw broccoli) and a non-modelled vegetable (cucumber).MethodsYoung adult women (N = 205) were randomised to watch a video of unfamiliar adult models eating raw broccoli with a positive, negative, or neutral facial expression. Participants’ change in liking and change in desire to eat the modelled and non-modelled vegetable was examined.ResultsObserving models conveying negative facial expressions whilst eating raw broccoli resulted in a statistically significant reduction in liking ratings of broccoli, but not cucumber. There was no effect of models’ facial expressions on the change in desire to eat foods.DiscussionThese findings suggest that watching others express a negative facial expression whilst eating a raw vegetable reduces women’s liking of the modelled vegetable, in the absence of a significant change to their desire to consume these foods. This highlights the power of others’ negative facial expressions on food liking. Further work is needed to establish the effect of others’ facial expressions on vegetable intake.
Effects of affectively-loaded childhood-related photos from the IAPS on the induction of involuntary autobiographical memories in young and older adults
Authors: Navarro Beatriz , Jimeno María Verónica , Fernández-Aguilar Luz , Nieto Marta , Toledano-González Abel , Cantero María José , Ros Laura , Latorre José Miguel 
Published: January 2024

ObjectiveAging produces changes in emotional reactivity and the retrieval of autobiographical memories. The main aim of this study was to assess age-related differences, comparing emotion induction and autobiographical memory recall using photos from the International Affective Picture System (IAPS) that are thematically related to childhood.MethodA cross-sectional observational study was conducted, with the participation of 327 individuals (168 young adults and 159 older adults) with no cognitive impairment and aged between 18 and 88 years. We showed the participants a set of five pictures from the IAPS, the affective content of which was related to childhood. Two of these were considered to be positive images, two negative and one neutral, according to the valence of these pictures in the literature. The main study variables were the reactions associated with emotional valence or pleasure, arousal and dominance, after viewing the photos, and the autobiographical memories retrieved by the participants.ResultsThe younger adults retrieved a larger number of memories than their older counterparts. As regards the responses to the five affective pictures (IAPS) on valence, arousal and dominance (IAPS), statistically significant differences were only found for pictures 2,345 (BlackEye), with a more positive valence in the group of older adults and higher arousal in the young ones, and 2,312 (Mother), with a more positive valence in the group of older persons. A greater number of memories were retrieved for the photos that generated higher levels of pleasure, greater relaxation and greater emotional control.ConclusionOf the variables that may be associated with the elicitation of involuntary autobiographical memories, the most significant are age and a positive stimulus.
Effect of short video addiction on the sleep quality of college students: chain intermediary effects of physical activity and procrastination behavior
Authors: Zhao Zhe , Kou Yali 
Published: January 2024

IntroductionThe purpose of this study was to examine the impact of short video addiction on college students' sleep quality and to elucidate the mechanism underlying this relationship. Thus, we examined the correlation between short video addiction and sleep quality and analyzed the roles of physical activity and procrastination.MethodsThe Short Video Addiction Scale, Pittsburgh Sleep Quality Index, Aitken Procrastination Inventory, and Physical Activity Rating Scale were administered to 337 college students. Data were analyzed using SPSS 27.0. Pearson's correlation analysis and mediation analysis using the bootstrapping test were performed for the standard method bias test.Results(1) Overall, 25.2% of college students had problems with sleep quality (indicated by a PSQI score ≥ 8). (2) Short video addiction score is positively correlated with college students' sleep quality score; procrastination score was positively associated with both short video addiction score and sleep quality score, and physical activity score was negatively associated with them. (3) Short video addiction significantly positive predicted sleep quality (β = 0.458, P &lt; 0.001), a significant negative predictive effect on physical exercise (β = −0.183, P &lt; 0.001), and a significant positive effect on procrastination behavior (β = 0.246, P &lt; 0.001). After physical exercise and procrastination behavior were entered into the regression equation, short video addiction and procrastination were significantly positive predictors of sleep quality, and physical activity was significantly negative predictor of sleep quality. (4) After accounting for the variables of age, gender, and grade, physical activity and procrastination behaviors independently mediated the association between short-video addiction and sleep quality. Physical activity and procrastination behavior acted as chain mediators in the association between short video addiction and sleep quality, with a chain mediation effect percentage of 1.04%. Short video addiction directly affects college students' sleep quality, indirectly through physical activity and procrastination behavior.
Trajectories of quality of life in people with diabetes mellitus: results from the survey of health, ageing and retirement in Europe
Authors: Mendorf Sarah , Heimrich Konstantin G. , Mühlhammer Hannah M. , Prell Tino , Schönenberg Aline 
Published: January 2024

IntroductionPrevious longitudinal studies identified various factors predicting changes in Quality of Life (QoL) in people with diabetes mellitus (PwDM). However, in these studies, the stability of QoL has not been assessed with respect to individual differences.MethodsWe studied the predictive influence of variables on the development of QoL in PwDM across three waves (2013–2017) from the cross-national panel dataset Survey of Health, Ageing, and Retirement in Europe (SHARE). To determine clinically meaningful changes in QoL, we identified minimal clinically important difference (MCID). Linear regressions and Linear Mixed Models (LMM) were conducted to determine factors associated with changes in QoL.ResultsOn average, QoL remained stable across three waves in 2989 PwDM, with a marginal difference only present between the first and last wave. However, when looking at individual trajectories, 19 different longitudinal patterns of QoL were identified across the three time-points, with 38.8% of participants showing stable QoL. Linear regression linked lower QoL to female gender, less education, loneliness, reduced memory function, physical inactivity, reduced health, depression, and mobility limitations. LMM showed that the random effect of ID had the strongest impact on QoL across the three waves, suggesting highly individual QoL patterns.ConclusionThis study enhances the understanding of the stability of QoL measures, which are often used as primary endpoints in clinical research. We demonstrated that using traditional averaging methods, QoL appears stable on group level. However, our analysis indicated that QoL should be measured on an individual level.
Effect of dynamic balance on human mental rotation task in female badminton vs. volleyball players
Authors: Amara Samiha , Al-Hadabi Badria , El-Ashkar Heba , Gmada Nabil , Habacha Hamdi , Mkaouer Bessem 
Published: January 2024

BackgroundThe present study aims to compare the mental rotation performance between two non-contact sports (i.e., badminton and volleyball) in different upright conditions (i.e., with and without dynamic balance).MethodsThirty-five female sports and physical education students voluntarily participated in the experiment, including fourteen specialists in badminton and twenty-one specialists in volleyball. The experiment involved a mental body rotation task with or without balance exercises on a wobble board.ResultsBadminton players outperformed volleyball players in the mental rotation tasks regardless of balance. More interestingly, the results revealed an overall decrease in reaction times when participants performed balance exercises simultaneously with mental rotation.DiscussionOur findings suggest that introducing dynamic balance on a wobble board has immediate beneficial effects on the mental rotation performance of female badminton and volleyball players. These findings are discussed in the context of sport specificities and cognitive processing framework.
Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators
Authors: Yang Rongrong , Lin Zhenguo , Cai Yanhua , Chen Nan , Zhou Ying , Zhang Jie , Hong Guolin 
Published: January 2024

BackgroundPrenatal depressive symptoms (PDS) is a serious public health problem. This study aimed to develop an integrated panel and nomogram to assess at-risk populations by examining the association of PDS with the serum metabolome, multivitamin supplement intake, and clinical blood indicators.MethodsThis study comprised 221 pregnant women, categorized into PDS and non-PDS groups based on the Edinburgh postnatal depression scale. The participants were divided into training and test sets according to their enrollment time. We conducted logistic regression analysis to identify risk factors, and employed liquid chromatography/high resolution mass spectrometry-based serum metabolome analysis to identify metabolic biomarkers. Multiple factor analysis was used to combine risk factors, clinical blood indicators and key metabolites, and then a nomogram was developed to estimate the probability of PDS.ResultsWe identified 36 important differential serum metabolites as PDS biomarkers, mainly involved in amino acid metabolism and lipid metabolism. Multivitamin intake works as a protective factor for PDS. The nomogram model, including multivitamin intake, HDL-C and three key metabolites (histidine, estrone and valylasparagine), exhibited an AUC of 0.855 in the training set and 0.774 in the test set, and the calibration curves showed good agreement, indicating that the model had good stability.ConclusionOur approach integrates multiple models to identify metabolic biomarkers for PDS, ensuring their robustness. Furthermore, the inclusion of dietary factors and clinical blood indicators allows for a comprehensive characterization of each participant. The analysis culminated in an intuitive nomogram based on multimodal data, displaying potential performance in initial PDS risk assessment.