bluuebunny/crossref_metadata_2025_split huggingface dataset:
NIOSOMES A PROMISSING NANOCARRIER: A REVIEW
Authors: BHANGE MANJUSHA A. , PETHE ANIL M. , JADHAV AMRAPALI 
Published: November 2023

There are numerous traditional methods for applying medications to the skin. Transdermal has become a popular method of drug delivery in recent years for a variety of medications that are difficult to administer in other ways. Transdermal drug delivery has a number of advantages, the most important of which is the prevention of first-pass metabolism and the stomach environment, which would render the drug inactive. In addition to discussing in depth the various formulation techniques and permeability enhancement for improved therapeutic efficacy, a transdermal patch allows for the controlled release of medication into the patient, typically through membrane pores that house a reserve of medication or over body heat that melts thin layers of medication entrenched in the adhesive.
The drug molecules can permeate the skin and be administered in this manner. Niosomes are vesicles made of non-ionic surfactants that are more stable, biodegradable, and generally harmless. Because surfactants are more chemically stable than lipids, niosomes are ideal for liposomes. The main topics of this review study are the concept of niosome, its benefits and drawbacks, composition, various type of transdermal formulation, enhancers using in this delivery and novel transdermal drug delivery, variables influencing niosomes, characterization, and use of noisome. Niosomes can be used to carry both amphiphilic and lipophilic drugs. Niosomes have great potential in targeted drug delivery of anticancer and anti-infective agents. This review article represents the structure of Niosomes, its advantages and disadvantages, types of niosomes, applications, method of preparation of niosomes.
MOLECULAR DOCKING AND DYNAMIC SIMULATION-BASED SCREENING IDENTIFIES INHIBITORS OF TARGETED SARS-COV-2 3CLPRO AND HUMAN ACE2
Authors: GALGALE SARVESH , ZAINAB RIDA , KUMAR A. PRADEEP , M. NITHYA , D. SUSHA , SHARMA SAMEER 
Published: November 2023

Objective: Several genetic variations of Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) are continuously arising due to the uncontrolled dissemination of the virus during the pandemic. Omicron (B.1.1.529), the most prevalent variation of concern, has demonstrated extraordinary proliferation and pathogenicity and has emerged as the dominant variant as it has inflicted mass casualties worldwide.
Methods: Impeding the expression of 3CLpro, a coronavirus protease that is essential for digesting the RNA polyproteins, and the human angiotensin-converting enzyme 2 (ACE2) that serves as a receptor for the viral protein is identified as a competent therapeutic target. In the current study, human ACE2 and the viral 3CLpro complex was the target for the designing of novel drugs against the lethal virus. The docked complex was validated by Procheck, and the covid ligand library was investigated for its pharmacological efficacy using admetSAR 2.0. The molecular docking study was performed with the screened compounds obtained from the PubChem database against the docked protein complex.
Results: The ACE2 and 3CLpro proteins were docked together and the best docked complex was utilized for the analysis of the 1,87,419 compounds retreived from the PubChem COVID library, 18,642 compunds fulfilled the pharmacological screening and were appraised for docking with ACE2-3CLpro complex. The molecular docking results presented that the compounds 1-(4-fluorophenyl)-N'-(4-methylphenyl)propane-1,3-diamine (CID: 10038137) demonstrated significantly better binding (-18.7 kacl/mol) with favourable pharmacological properties and was therefore subjected to molecular dynamic simulations using Desmond Schrodinger 2019.2 GPU enabled package for 100 ns trajectory. The complex structure was observed to be stable after 15 ns and the average RMSD was observed to be ~0.65 nm. The complete binding energy of the complex with respect to MD simulation was-134.998+/-18.435 kj/mol which exposed that the inhibitor has a higher affinity towards the 3Clpro-ACE2 complex.
Conclusion: Consequently, this compound can be used to develop anti-covid medications to combat complications associated with Omicron infection.
DESIGN AND OPTIMIZATION OF NANO ENCAPSULATED BERBERIS ASIATICA BIO COMPOUNDS
Authors: POSINASETTY BHARGAVI , KOMMINENI SRIVIDYA , KUMARACHARI RAJASEKHAR KOMARLA , BANDARAPALLE KISHORE 
Published: November 2023

Objective: The current study goal is to develop and optimize nanoencapsulated biocompounds of Berberis asiatica (BCBA) utilizing the ionic gelation process to target the kidney for antiurolithiatic activity.
Methods: Nanoencapsulated BCBA was prepared employing the ionic gelation method. Box Behnken Design (BBD) 3-factor, 3-level is used to examine the effects of formulation parameters and to enhance the desired responses. Characterization studies include Fourier transform infrared (FTIR), X-ray diffraction (XRD), particle size, zeta potential, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) performed to study the quality of optimized nanoparticles.
Results: Mathematical equations and response surface plots were used to relate the dependent and independent variables. Diagnostic charts were used to show the varied factor level permutations. The percentages of entrapment efficiency (% EE) and drug release (% DR) used in evaluation studies of optimized biocompounds of Berberis asiatica nanoparticles (OBCBANPs) were determined to be 83.7% and 78.33%, respectively. The Fourier transform infrared (FTIR) results showed that chitosan, sodium tripolyphosphate (NaTPP), and BACB were compatible. Due to chitosan and NaTPP gelation in the case of OBCBANPs, X-ray diffraction (XRD) analyses have acknowledged the crystalinity. The particle size and zeta potential of the optimized formulation, found to be 95.4 nm and 31 mV, respectively, indicate the nanoparticles are in the nano range and possess extreme stability by preventing particle convergence. Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) studies reveal that the optimized formulation nanoparticles are spherical in shape, homogeneous, and have little aggregation. The accelerated stability studies showed that the optimized formulation was stable at different temperatures and relative humidity.
Conclusion: The stable optimized formulation was prepared, evaluated, and characterized. BBD is employed to optimize the formulation by minimizing the number of experimental runs and enhancing the desired responses. The optimized formulation further needs to investigate the invivo studies for antiurolithiatic activity by targeting the kidney.
SILVER NANOPARTICLES INHIBIT INFECTIOUS BRONCHITIS VIRUS REPLICATION
Authors: SAADH MOHAMED J. 
Published: November 2023

Objective: Avian infectious bronchitis virus (IBV) threatens the poultry industry and causes global economic losses. The IBV is highly variable. Thus, no effective drugs are available. Objective of the present study was to evaluate silver nanoparticles against it as an antiviral agent.
Methods: Silver nanoparticles (AgNPs) have been evaluated as antivirals against IBV. P. betle leaf extract biosynthesizes AgNPs from silver nitrate. UV/vis absorption, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM) have been used to characterize AgNPs. TEM indicated particle sizes of 5–30 nm, and XRD demonstrated their characteristic AgNPs structure. The antiviral activity of AgNPs was measured by the log embryo infective dose 50 (logEID50)/ml and the number of IBV genome copies.
Results: XRD analysis showed a structure for AgNPs, and transmission electron microscopy showed a size of 5–30 nm for AgNPs. AgNPs at a noncytotoxic concentration inhibit the interaction between the virus and the cell, preventing the virus from entering the cell and reducing the number of IBV genome copies (per µl) in ovo by preventing the formation of the IBV RNA genome, resulting in a significant reduction in the IBV titer.
Conclusion: AgNPs possess antiviral properties that inhibit IBV replication in ovo. The findings indicate that AgNPs are a promising drug candidate for treating or preventing IBV infection.
DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF ENTRECTINIB NANOSPONGES LOADED TABLETS FOR ORAL DELIVERY
Authors: PALANATI MAMATHA , BHIKSHAPATHI D. V. R. N. 
Published: November 2023

Objective: As Entrectinib is a lipophilic, basic, moderately permeable molecule with strongly pH-dependent solubility with antitumor activity in advanced and metastatic solid tumors, the current study was designed to improve the oral solubility of Entrectinib through incorporation into nanosponges tablets (NSs).
Methods: Box-Behnken Design was used to optimize the independent variables of β-Cyclodextrin (β-CD) NSs formation. β-CD NSs were prepared by an ultrasound-assisted method using diphenyl carbonate as cross-linking agent, which were later characterized and formulated into tablets by wet granulation method. The prepared tablets were evaluated for the physico-chemical properties and in vitro release of the drug.
Results: A series of fifteen experiments were performed based on the experimental runs generated from a three-factor, three-level Box–Behnken design (BBD). The range of mean particle size was 149-294 nm, the range for encapsulation efficiency % was 65.4%-87.3%, and the value for polydispersity index was 0.437. The zeta potential for the optimized formulation was found to be 38.1 Mv. The drug and excipients were compatibles as confirmed by Fourier Transformed Infrared (FTIR) Spectroscopy and Differential Scanning Calorimetry (DSC) studies. Scanning Electron Microscopic (SEM) analysis confirmed that the Entrectinib has successfully entrapped in the core of polymer. In vitro release of the Entrectinib-loaded NSs tablets (six compositions) were compared with a marked product and satisfactory results were obtained. It was observed that rapid dissolution occurred in 0.1 N HCl for first 2 h (15.64±1.52% vs. 12.67±1.89%) and 98.94±2.43% of drug release was observed in Entrectinib loaded NSs and 91.78±1.37% in marketed product in 24 h. The prepared formulations were stable during 6 mo stability study period.
Conclusion: The study results studies of Entrectinib NS tablets indicated rapid dissolution due to changed solubility properties of the drug, compared to pure drug meeting the set objective of enhanced absorption. The formulated Entrectinib-loaded NSs can be beneficial in the treatment of cancers.
QUALITY CONTROL ASSESSMENT OF DUTASTERIDE AND SILODOSIN IN CAPSULES AND TABLETS EMPLOYING A NOVEL DEVELOPED HPLC TECHNIQUE; EVALUATION OF STABILITIES OF DUTASTERIDE AND SILODOSIN IN ACCELERATED DEGRADATION
Authors: JAGADEESH KADALI , KADIYALA K. GANESH , VARMA DENDUKURI B. N. SURESH , GUTTULA RAMA SWAMY , GUPTA TIRUVEEDHI V. L. N. BALAJI , VAMSI PEDDINTI , CHAVAKULA RAJYA LAKSHMI 
Published: November 2023

Objective: The combination of dutasteride (DTRE) plus silodosin (SLDN) is used for treating acute urine retention brought upon by benign prostatic hyperplasia in men. The contents of DTRE and SLDN in capsules and tablets must be monitored for quality. In this research, a quick, selective and robust stability indicating HPLC method has been developed for concurrent assay of DTRE and SLDN in capsules and tablets. Also, the stabilities of DTRE and SLDN under several types of applied stress were determined. Methods: Analysis performed using Xterra Symmetry type column C18 (“4.6 mm x 150 mm, 5 mm” dimensions) and mobile phase having 0.1N strength, 20% volume fraction of dipotassium hydrogen phosphate and 80% volume fraction of pure form acetonitrile; PDA analysis was made at 265 nm. Stabilities of DTRE and SLDN were determined under several types of applied stress, including thermal, basic, oxidative, photo, and acid. Results: The elution times for DTRE and SLDN were 2.003 min and 3.377 min, respectively. DTRE and SLDN linear ranges were 20–120 µg/mL and 1.25–7.5 µg/mL, respectively. Method is precise with 0.2498% (DTRE) and 0.0773% (SLDN) RSD values. Method is accurate with 98.913-101.049% (DTRE) and 100.023-100.162% (SLDN) recovery values. In degradation investigation, degradant’s peaks elution times are different from the elution times of DTRE and SLDN. Thus, proved specificity and stability indicating power of the method. DTRE and SLDN were found relatively stable in thermal and were found sensitive in oxidation. In overall, SLDN found more sensitive to applied stress, including thermal, basic, oxidative, photo, and acid compared to DTRE. Conclusion: Finally, this developed analytical approach was efficaciously applied to a commercial capsule and tablet formulations containing fixed dose of DTRE and SLDN, demonstrating its usefulness for quality control and degradation investigations on DTRE and SLDN.
Tinjauan Hukum terhadap Kewajiban Pembayaran Kredit Akibat Force Majeur pada Pembiayaan Konsumen
Authors: Puspita Dinda Putri , Erlina  , Basri Ade Darmawan 
Published: November 2023

Munculnya wabah Covid-19 membuat perekonomian menjadi tidak stabil, dimana ditandai dengan berbagai kebijakan-kebijakan seperti PSBB, Lockdown,dll membuat segala aktifitas terhambat. Terhambatnya segala aktifitas perekonomian membuat sebagian masyarakat tidak dapat memenuhi kewajiban yang harus dipenuhi, salah satunya kewajiban dalam melakukan pembayaran kredit pada Lembaga Non Bank seperti perusahaan pembiayaan. Tidak memenuhi kewajiban ini tentu dapat membuat debitur menjadi wansprestasi. Namun tidak memenuhi suatu kewajiban tentu diakibatkan oleh berbagai hal, salah satunya keadaan memaksa atau biasa disebut Force Majeure. Force Majeure dapat digolongkan menjadi dua yaitu absolud dan realtif. Force Majeure yang diakibatkan oleh Covid-19 ini dapat dikategorikan dalam relatif, dimana debitur dapat menunda kewajibannya untuk sementara waktu. Maka pemerintah melalui Otoritas Jasa Keuangan mengeluarkan kebijakan terkait Restrutkturisasi Kredit POJK Nomor 14/POJK.05/2020 tentang Kebijakan Countercyclical Dampak Penyebaran Coronavirus Disease 2019 Bagi Lembaga Jasa Keuangan Non Bank
Improving Student Digital Literacy through Google Classroom-Based Lectures
Authors: Sadieda Lisanul Uswah , Sutini Sutini 
Published: November 2023

Abstract:Mathematics teacher candidates need to have good digital literacy so that they will be able to guide their students to use digital media wisely. Therefore this study aims to describe the increase in students' digital literacy after attending microteaching lectures (Introduction to Schooling Field 1) using Google Classroom. This type of research is quasi-experimental research with a quantitative approach. The research sample was 30 students in the 6th semester of the 2021/2022 academic year. Methods of collecting data using performance tests. Data analysis of students' digital literacy improvement used the Wilcoxon Signed-Rank Test. Digital literacy indicators used include aspects of technical skills, critical understanding, and communicative abilities. Based on the analysis of research data, it is concluded that there is an increase in student digital literacy after attending lectures using Google Classroom. Student digital literacy is included in the advanced category.Abstrak:Mahasiswa calon guru matematika perlu memiliki literasi digital yang baik agar nantinya mampu membimbing peserta didiknya menggunakan media digital dengan bijak. Oleh karena itu penelitian ini bertujuan mendeskripsikan peningkatan literasi digital mahasiswa sesudah mengikuti perkuliahan microteaching (Pengenalan Lapangan Persekolahan 1) menggunakan Google Classroom. Jenis penelitian adalah penelitian eksperimen semu dengan pendekatan kuantitatif. Sampel penelitian adalah 30 mahasiswa semester 6 tahun akademik 2021/2022. Metode pengumpul data menggunakan tes unjuk kerja. Analisis data peningkatan literasi digital mahasiswa menggunakan uji Wilcoxon Signed-Rank Test. Indikator literasi digital yang digunakan meliputi aspek technical skill, critical understanding dan communicative abilities. Berdasarkan analisis data penelitian diperoleh simpulan bahwa terdapat peningkatan literasi digital mahasiswa setelah mengikuti perkuliahan menggunakan Google Classroom, Literasi digital mahasiswa termasuk dalam kategori advance.
Hydroxyurea ulcers of unusual location: a case report and review of literature
Authors: Miguel Mansilla-Polo , Miguel Ángel Navarro-Mira , Rafael Botella-Estrada 
Published: November 2023

Abstract
Hydroxyurea is a cytotoxic drug that has been used for decades for the treatment of various entities, mostly hematologic, especially polycythemia vera. Its side effects are varied, including dermatological ones, ranging from skin xerosis to hyperpigmentation, lesions like dermatomyositis and shows even a relationship with premalignant processes (actinic keratosis) and non-melanoma cancer (squamous, basal cell, Merkel, and oral tumors).
In this paper, we report a clinical case of a relatively frequent adverse effect of hydroxyurea, but of extraordinary localization and clinical presentation.
The association of ulcers with taking hydroxyurea is well known. Most of the time, these appear in the lower limbs and in patients with chronic vascular pathology. However, in our patient, the location was both hands and was associated with dermatomyositis-like lesions, nail hyperpigmentation, and skin changes. The therapeutic response with withdrawal was spectacular. Knowledge of this condition is vitally important for the hematologist and dermatologist to ensure adequate care.
Correlation between Cone Penetration Test parameters, soil type, and soil liquidity index using long short-term memory neural network
Authors: Jocz Mateusz , Lefik Marek 
Published: November 2023

Abstract
Accuracy and quality of recognizing soil properties are crucial for optimal building design and for ensuring safety in the construction and exploitation stages. This article proposes use of long short-term memory (LSTM) neural network to establish a correlation between Cone Penetration Test (CPTU) results, the soil type, and the soil liquidity index IL
. LSTM artificial neural network belongs to the class of networks requiring deep machine learning and is qualitatively different from artificial neural networks of the multilayer perceptron type, which have long been widely used to interpret the results of geotechnical experiments. The article outlines the methodology of CPTU testing and laboratory testing of the liquidity index, as well as construction and preparation of data for the network. The proposed network achieved good results when considering a database consisting of the parameters of eight CPTU soundings, soil stratifications, and laboratory test results.
Pengaruh Brand Loyalty terhadap Keputusan Pembelian Konsumen Crooz_id
Authors: Aurelius Susianto Adriel , Erdiansyah Rezi 
Published: November 2023

The distribution industry in Indonesia is growing every year. This is evidence of loyal customers who indirectly support demand for more production. It's no wonder that distributors like Crooz_id focus on building customer loyalty. Therefore, this study aims to cover the effect of brand loyalty in building purchasing decisions in the distribution industry with Crooz_id products as a context for overall consideration by researchers. This study uses the Crooz_id design and research methods using quantitative methods and data collection techniques distributing questionnaires to 100 respondents who are crooz_id Instagram followers. by using non-probability sampling. The data obtained is processed using validity test, reliability test, normality test, simple regression analysis test and t test. The results of the study show that the motivation of Crooz_id buyers has a significant effect on the fulfillment of needs in buying Crooz-id products.

Industri distribusi di Indonesia semakin berkembang setiap tahun. Hal ini sebagai bukti loyal pelanggan yang secara tidak langsung mendukung permintaan produksi yang lebih. Tidak heran jika distributor seperti Crooz_id fokus dalam membangun loyalitas pelanggan. Oleh karena itu, penelitian ini bertujuan untuk menyelidiki efek dari brand loyalty dalam membangun keputusan pembelian pada industri distro dengan produk Crooz_id sebagai konteks pertimbangan secara keseluruhan oleh peneliti. Penelitian ini menggunakan desain Crooz_id dan metode penelitian menggunakan metode kuantitatif dan teknik pengumpulan data menyebarkan kuesioner kepada 100 responden yang merupakan pengikut Instagram Crooz_id. dengan menggunakan non-probability sampling. Data yang diperoleh diolah dengan menggunakan uji validitas, uji reliabilitas, uji normalitas, uji analasis regresi sederhana dan uji t. Hasil penelitian menunjukkan bahwa motivasi konsumsi pembeli Crooz_id berpengaruh signifikan terhadap kepuasaan pemenuhan kebutuhan dalam membeli produk Crooz-id.
Komunikasi Pemasaran Media Sosial Instagram @carameleatery
Authors: Ekklesia Gabriella Anandia , Farid Farid 
Published: November 2023

This culinary cafe business is getting crowded thanks to Instagram trends. The concept of "Instagramable", which attracts buyers and sellers through various forms of advertisements through content marketing, has become a new trend in major cities in recent years. Caramel Eatery's marketing communications strategy is to create marketing content through Instagram, which is then used as a messaging medium and marketing. The purpose of this study is to determine the marketing communication strategy of Caramel Eatery on Instagram social media. This study adopts qualitative description method and uses IMC (Integrated Marketing Communication) theory. This study shows that Caramel Eatery's marketing communications strategy uses Instagram social media because it is cheap, easy, and has a wide reach in marketing.

Pemasaran konten dapat melibatkan konsumen dengan menciptakan interaksi di antara pelanggan. Maraknya industri kedai kopi telah menciptakan pasar baru bagi para pengusaha di bidang kuliner dan khususnya peluang yang sangat besar bagi masyarakat. Berkat tren Instagram, bisnis kuliner di kedai kopi ini semakin ramai. Berbagai bentuk konsep “Instagramable” yang menarik pembeli dan penjual melalui content marketing menjadi tren baru di kota-kota besar dalam beberapa tahun terakhir. Strategi komunikasi pemasaran yang dilakukan oleh Caramel Eatery adalah membuat konten pemasaran melalui Instagram yang kemudian digunakan sebagai media pesan dan sarana pemasaran. Tujuannya adalah untuk mengerti strategi komunikasi pemasaran Caramel Eatery melalui Instagram. Penelitian ini menggunakan metode deskripsi kualitatif dan menggunakan teori IMC (Integrated Marketing Communication). Hasil penelitian Caramel Eatery belum berhasil menggunakan komunikasi pemasaran terpadu, karena Caramel Eatery belum memasan iklan di media massa, hanya dengan melakukan promosi di media sosial Instagram.