bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of an echocardiographic index to characterize right ventricular–pulmonary arterial coupling in heart failure
Authors: Chen Xin , Zhang Peige , Lou Jie , Zhao Ruohan , Zhang Siyi , Xie Mingxing , Lv Qing 
Published: January 2024

AbstractHeart failure (HF), with its high morbidity and mortality, remains a global public health issue. Right ventricular (RV) dysfunction is a sign of deterioration in the natural history of HF, and a thorough evaluation of the relationship between RV contractility and its afterload through RV–pulmonary arterial (RV–PA) coupling can aid in accurately assessing overall RV function. The ratio of RV end‐systolic elastance (Ees) to pulmonary arterial elastance (Ea) invasively measured by right heart catheterization served as the gold standard for evaluating RV–PA coupling. An echocardiographic index termed tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) has been shown to correlate well with Ees/Ea. TAPSE/PASP is recognized as a non‐invasive surrogate of RV–PA coupling and has been extensively studied in patients with HF. This review briefly describes the methods of assessing RV–PA coupling, mainly discussing echocardiography, summarizes the clinical utility of TAPSE/PASP in patients with different HF types, and provides an overview of the available literature.
On the influence of bed roughness on saltation in inertial regime
Authors: Minster Gaspard , Floc'h France , Valance Alexandre , Le Dantec Nicolas , Nicolle Amandine , Zerr Benoit 
Published: January 2024

AbstractIn extreme tidal environment, occurrences of saltating pebbles have been observed. The ambition to instal hydrokinetic turbines in such environment requires knowledge on the presence of pebbles in saltation in the water column because they can damage the structures. An experimental study is realized in a free‐surface flume with no slope and different bed roughnesses as in marine environment. With fast camera the trajectories of hundreds of spherical particles are analysed. Our study deals with saltation in the inertial regime (i.e., large Stokes number) over fixed beds with various roughnesses. In inertial regime, the bed roughness has more influence on the collision process and the trajectory of the particles than for non‐inertial motion where viscous forces play a key role. Jump height and length increase with bed roughness, with height increasing quicker than length leading to a more vertical trajectory for higher bed roughness. The vertical restitution coefficient is shown to increase with bed roughness leading to higher jumps. The initiation of the motion is shown to depend on the bed roughness as well. Power laws of the excess shear stress are proposed for jump height and length, taking into account the bed roughness. The dataset and analysis proposed in this study is a key ingredient for developing quantitative models for particle transport.
Recent advances in reactive oxygen species scavenging nanomaterials for wound healing
Authors: Joorabloo Alireza , Liu Tianqing 
Published: January 2024

AbstractReactive oxygen species play a crucial role in cell signaling pathways during wound healing phases. Treatment strategies to balance the redox level in the deep wound tissue are emerging for wound management. In recent years, reactive oxygen species scavenging agents including natural antioxidants, reactive oxygen species (ROS) scavenging nanozymes, and antioxidant delivery systems have been widely employed to inhibit oxidative stress and promote skin regeneration. Here, the importance of reactive oxygen species in different wound healing phases is critically analyzed. Various cutting‐edge bioactive ROS nanoscavengers and antioxidant delivery platforms are discussed. This review also highlights the future directions for wound therapies via reactive oxygen species scavenging. This comprehensive review offers a map of the research on ROS scavengers with redox balancing mechanisms of action in the wound healing process, which benefits development and clinical applications of next‐generation ROS scavenging‐based nanomaterials in skin regeneration.
The effects of raspberry consumption on lipid profile and blood pressure in adults: A systematic review and meta‐analysis
Authors: Jazinaki Mostafa Shahraki , Bahari Hossein , Rashidmayvan Mohammad , Arabi Seyyed Mostafa , Rahnama Iman , Malekahmadi Mahsa 
Published: January 2024

AbstractResearch into the effects of raspberry on blood pressure and lipid profiles is inconclusive. This meta‐analysis was aimed to determine whether raspberry has beneficial effects in clinical practice and to what extent these effects are associated with blood pressure and lipid profiles. A systematic literature search up to September 2023 was completed in PubMed/Medline, Scopus, and Web of Science, to identify eligible RCTs. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random effects models were evaluated based on the heterogeneity tests, and pooled data were determined as weighted mean differences with a 95% confidence interval. Eleven randomized controlled trials (with 13 arms) were eligible for this meta‐analysis. Our findings revealed that Raspberry consumption had no significant effects on the blood pressure and lipid profile markers, including systolic blood pressure (SBP) (WMD, −0.37 mm Hg; 95%CI: −2.19 to 1.44; p = .68), diastolic blood pressure (DBP) (WMD, −2.14 mm Hg; 95%CI: −4.27 to 0.00; p = .05), total cholesterol (TC) (WMD, −6.83 mg/dL; 95%CI: −15.11 to 1.44; p = .10), triglycerides (TG) (WMD, −5.19 mg/dL: 95%CI: −11.76 to 1.37; p = .12), low‐density lipoprotein‐cholesterol (LDL‐C) (WMD, −5.19 mg/dL; 95%CI: −11.58 to 1.18; p = .11), and high‐density lipoprotein‐cholesterol (HDL‐C) (WMD, 0.82 mg/dL; 95%CI: −1.67 to 3.32; p = .51), compared to control groups. Subgroup analysis showed that raspberry consumption significantly decreased total cholesterol and LDL‐C levels in people with elevated TC levels, metabolic syndrome, and andropause symptoms, as well as those older than 35, while the consumption of raspberries led to a significant increase in HDL‐C levels in females, obese, under 35, and healthy individuals. Raspberry can improve lipid profile and blood pressure, but it is important to keep in mind that further research is necessary to fully understand the exact mechanism of action and a definite conclusion in this regard.
Infant and early childhood teleconsultation and training: Program description and feasibility outcomes from a statewide implementation
Authors: Loomis Alysse M. , McLaughlin Rose X. , Lyon McCall , Mitchell Jennifer 
Published: January 2024

AbstractTo address high rates of mental health and developmental concerns facing young children ages 0–6 in the United States and internationally, providers across professional sectors need Infant and early childhood mental health (IECMH) training and support. The training and teleconsultation program (TTP) is a state‐funded program developed in one Mountain West state in the United States to provide free IECMH training and teleconsultation to any provider working with young children. The TTP included access to webinars and individual or group consultation with licensed mental health providers. Webinars focused on increasing awareness and knowledge related to attachment and child development, supporting parents and caregivers, trauma‐informed practice, supporting emotional health of staff and providers, and culturally responsive practices with infants, young children, and caregivers. Teleconsultation included case consultation, reflective individual and group supervision, and collaboration supports/referrals. During the 18‐month evaluation period, 1568 unique providers engaged in either training or teleconsultation services, an average of 9% growth in new providers each month, with representation from all professional sectors and all state counties. This program demonstrates the feasibility and need for statewide training and teleconsultation programs to help meet the needs of providers who interact with and support young children and caregivers.
Wick irrigation improves seed yield and water use efficiency in mung bean
Authors: Rezaei Mansoor , Heidari Hassan 
Published: January 2024

AbstractDrought is a serious threat to crop growth, and finding new irrigation methods can save water. This study was conducted to investigate water use efficiency and seed yield in mung bean under wick irrigation. Irrigation treatments consisted of the wick irrigation method, surface irrigation (common irrigation) with water equivalent to wick irrigation, and surface irrigation with the double water use of wick irrigation. The results showed that the wick irrigation had a seed weight per plant, 100‐seed weight, seed number per pod, pod number per plant, seed yield, biological yield, water use efficiency of seed, water use efficiency of biomass and net income increase of 164, 14, 28, 80, 164, 128, 164, 128 and 300%, respectively, compared to surface irrigation with an equivalent water volume of wick irrigation. Wick irrigation resulted in increases in plant height, internode length, leaf number per plant, node number per plant, branch number per plant, leaf length and leaf width of 60, 59, 65, 91, 91, 52 and 52%, respectively, compared to surface irrigation with an equivalent water volume of wick irrigation. In conclusion, the wick irrigation method, as a new method, can save water and improve seed yield and net income.
Wnt signaling in cell adhesion, development, and colon cancer
Authors: Tejeda‐Muñoz Nydia , Mei Kuo‐Ching 
Published: January 2024

AbstractWnt signaling is essential for embryonic development, influencing processes such as axis formation, cell proliferation and differentiation, cell fate decisions, and axon guidance. It also plays a role in maintaining tissue homeostasis in adult organisms. The loss of normal cell polarity and adhesion caused by Wnt signaling activation is a fundamental step for tumor progression and metastasis. Activating the canonical Wnt pathway is a driving force in many human cancers, especially colorectal, hepatocellular, and mammary carcinomas. Wnt causes the stabilization and nuclear transport of newly synthesized transcriptional regulator β‐catenin. The generally accepted view is that the canonical effects of Wnt growth factors are caused by the transcription of β‐catenin target genes. Here, we review recent findings that indicate Wnt is a regulator of many other cellular physiological activities, such as macropinocytosis, endosome trafficking, protein stability, focal adhesions, and lysosomal activity. Some of these regulatory responses occur within minutes and do not require new protein synthesis, indicating that there is much more to Wnt beyond the well‐established transcriptional role of β‐catenin. The main conclusion that emerges from these studies is that in basal cell conditions, the activity of the key protein kinase GSK3, which is inhibited by Wnt pathway activation, normally represses the actin machinery that orchestrates macropinocytosis with implications in cancer. These contributions expand our understanding of the multifaceted roles of Wnt signaling in cellular processes, development, and cancer, providing insights into potential therapeutic targets and strategies.
Development of the Core Outcome Set for Psychiatric Pharmacists
Authors: Reinstatler Kristina , Payne Gregory H. , Lister Jonathan F. , Moore Tera D. , Parmentier Brittany L. , Santos Ranel Troy , Cobb Carla D. 
Published: January 2024

AbstractObjectiveThe American Association of Psychiatric Pharmacists (AAPP) sought to develop a consensus‐based set of outcomes and measures to standardize psychiatric pharmacy practice and research. The measures in this Core Outcome Set for Psychiatric Pharmacists (COS‐PP) are designed to study the impact of psychiatric pharmacists caring for individuals living with psychiatric disorders.MethodsThe COS‐PP was developed using guidelines from the Core Outcome Measures in Effectiveness Trials (COMET) initiative. A committee systematically reviewed a catalog of 194 articles and 40 posters that referenced psychiatric disorders, patient‐level outcomes, and pharmacist interventions. From these initial 234 resources, 554 combinations of outcomes and measures were identified. Additional papers, guidelines, and feedback from experts increased the number to 592 combined outcomes and measures. The principal investigator consolidated the list to 46 potential outcomes. AAPP members were invited to complete a survey rating the 46 potential outcomes on five key factors: comprehensive, attributable to pharmacy, feasible, scientifically sound, and usable. These survey results were provided to the 18 Board‐Certified Psychiatric Pharmacists participating in a summit examining the potential outcomes and measures gleaned from literature review. Through discussion and refinement, consensus was achieved on the final COS‐PP.ResultsThe final COS‐PP included 21 outcomes, 14 of which included at least 1 measure (84 total measures). The outcomes were grouped according to the quadruple health care aims: better care, reduced healthcare costs, improved patient experience, and improved clinician well‐being.ConclusionsCOS‐PP will help define psychiatric pharmacists' support of the interdisciplinary team in addressing the quadruple health care aims. Using standardized outcomes across practice sites will allow aggregation of data on the impact of psychiatric pharmacists on patient care.
Addressing sample selection bias for machine learning methods
Authors: Brewer Dylan , Carlson Alyssa 
Published: January 2024

SummaryWe study approaches for adjusting machine learning methods when the training sample differs from the prediction sample on unobserved dimensions. The machine learning literature predominately assumes selection only on observed dimensions. Common approaches are to weight or include variables that influence selection as solutions to selection on observables. Simulation results show that selection on unobservables increases mean squared prediction error using popular machine‐learning algorithms. Common machine learning practices such as weighting or including variables that influence selection into the training or prediction sample often worsen sample selection bias. We propose two control function approaches that remove the effects of selection bias before training and find that they reduce mean‐squared prediction error in simulations. We apply these approaches to predicting the vote share of the incumbent in gubernatorial elections using previously observed re‐election bids. We find that ignoring selection on unobservables leads to substantially higher predicted vote shares for the incumbent than when the control function approach is used.
Impact of formulation on solid oxygen‐entrapping materials to overcome tumor hypoxia
Authors: McGovern Megan K. , Witt Emily , Rhodes Ashley C. , Kim Jinhee , Feig Vivian R. , Bi Jianling , Cafi Arielle B. , Hatfield Sam , Nwosu Ikenna , Byrne James D. 
Published: January 2024

AbstractTumor hypoxia, resulting from rapid tumor growth and aberrant vascular proliferation, exacerbates tumor aggressiveness and resistance to treatments like radiation and chemotherapy. To increase tumor oxygenation, we developed solid oxygen gas‐entrapping materials (O2‐GeMs), which were modeled after clinical brachytherapy implants, for direct tumor implantation. The objective of this study was to investigate the impact different formulations of solid O2‐GeMs have on the entrapment and delivery of oxygen. Using a Parr reactor, we fabricated solid O2‐GeMs using carbohydrate‐based formulations used in the confectionary industry. In evaluating solid O2‐GeMs manufactured from different sugars, the sucrose‐containing formulation exhibited the highest oxygen concentration at 1 mg/g, as well as the fastest dissolution rate. The addition of a surface coating to the solid O2‐GeMs, especially polycaprolactone, effectively prolonged the dissolution of the solid O2‐GeMs. In vivo evaluation confirmed robust insertion and positioning of O2‐GeMs in a malignant peripheral nerve sheath tumor, highlighting potential clinical applications.
Ibuprofen‐loaded bilayer electrospun mesh modulates host response toward promoting full‐thickness abdominal wall defect repair
Authors: Liu Jiajie , Tang Rui , Zhu Xiaoqiang , Ma Qiaolin , Mo Xiumei , Wu Jinglei , Liu Zhengni 
Published: January 2024

AbstractPro‐inflammatory response impairs the constructive repair of abdominal wall defects after mesh implantation. Electrospinning‐aid functionalization has the potential to improve the highly orchestrated response by attenuating the over‐activation of foreign body reactions. Herein, we combined poly(L‐lactic acid‐co‐caprolactone) (PLLA‐CL) with gelatin proportionally via electrospinning, with Ibuprofen (IBU) incorporation to fabricate a bilayer mesh for the repair improvement. The PLLA‐CL/gelatin/IBU (PGI) mesh was characterized in vitro and implanted into the rat model with a full‐thickness defect for a comprehensive evaluation in comparison to the PLLA‐CL/gelatin (PG) and off‐the‐shelf small intestinal submucosa (SIS) meshes. The bilayer PGI mesh presented a sustained release of IBU over 21 days with degradation in vitro and developed less‐intensive intraperitoneal adhesion along with a histologically weaker inflammatory response than the PG mesh after 28 days. It elicited an M2 macrophage‐dominant foreign body reaction within the process, leading to a pro‐remodeling response similar to the biological SIS mesh, which was superior to the PG mesh. The PGI mesh provided preponderant mechanical supports over the SIS mesh and the native abdominal wall with similar compliance. Collectively, the newly developed mesh advances the intraperitoneal applicability of electrospun meshes by guiding a pro‐remodeling response and offers a feasible functionalization approach upon immunomodulation.
Clock gene Per2 modulates epidermal tissue repair in vivo
Authors: Yujra Veronica Quispe , Silveira Ericka Janine Dantas da , Ribeiro Daniel Araki , Castilho Rogerio Moraes , Squarize Cristiane Helena 
Published: January 2024

AbstractWound healing can be influenced by genes that control the circadian cycle, including Per2 and BMAL1, which coordinate the functions of several organs, including the skin. The aim of the study was to evaluate the role of PER2 during experimental skin wound healing. Two groups (control and Per2‐KO), consisting of 14 male mice each, were anesthetized by inhalation, and two 6 mm wounds were created on their dorsal skin using a punch biopsy. A silicone ring was sutured around the wound perimeter to restrict contraction. The wound healing process was clinically measured daily (closure index) until complete wound repair. On Day 6, histomorphometric analysis was performed using the length and thickness of the epithelial migration tongue, in addition to counting vessels underlying the lesion by immunofluorescence assay and maturation of collagen fibers through picrosirius staining. Bromodeoxyuridine (BrdU) incorporation and quantification were performed using the subcutaneous injection technique 2 h before euthanasia and through immunohistochemical analysis of the proliferative index. In addition, the qualitative analysis of myofibroblasts and periostin distribution in connective tissue was performed by immunofluorescence. Statistically significant differences were observed in the healing time between the experimental groups (means: 15.5 days for control mice and 13.5 days for Per2‐KO; p = 0.001). The accelerated healing observed in the Per2‐KO group (p < 0.05) was accompanied by statistical differences in wound diameter and length of the migrating epithelial tongue (p = 0.01) compared to the control group. Regarding BrdU immunoreactivity, higher expression was observed in the intact epithelium of Per2‐KO animals (p = 0.01), and this difference compared to control was also present, to a lesser extent, at the wound site (p = 0.03). Immunofluorescence in the connective tissue underlying the wound showed a higher angiogenic potential in the Per2‐KO group in the intact tissue area and the wound region (p < 0.01), where increased expression of myofibroblasts was also observed. Qualitative analysis revealed the distribution of periostin protein and collagen fibers in the connective tissue underlying the wound, with greater organization and maturation during the analyzed period. Our research showed that the absence of the Per2 gene positively impacts the healing time of the skin in vivo. This acceleration depends on the increase of epithelial proliferative and angiogenic capacity of cells carrying the Per2 deletion.
Different factors identified by stakeholder group for barriers and facilitators to measurement‐based care implementation in behavioral health clinics
Authors: Yule Amy M. , Youn Soo Jeong , Dean Kimberlye , Woodward Diana W. , Firmin Elizabeth S. , Kramer Joanna , Stone Mira , Marques Luana , Wilens Timothy E. 
Published: January 2024

AbstractIntroductionDespite the benefits of measurement‐based care (MBC) in the behavioral health setting, there have been difficulties in implementation and low saturation. Although barriers and facilitators to MBC implementation have been identified, research has generally only included the perspective of one stakeholder group. The current study aims to examine the similarities and differences—by stakeholder group—in the identified barriers to and facilitators of implementing MBC in the behavioral health setting.MethodA purposeful sampling approach was used to recruit and conduct interviews and focus groups with stakeholders (clinicians, clinic leaders, and administrative staff) from four behavioral health clinics at an academic medical center that is part of a larger healthcare system. The data coding process included a directed content analytic approach whereby the coding team used an iterative process to analyze deidentified transcripts starting with a codebook based on the Consolidated Framework for Implementation Research (CFIR) constructs.ResultsA total of 31 clinicians, 11 clinic leaders, and 8 administrative staff participated in the interviews and focus groups. There was convergence among all stakeholder regarding which CFIR constructs were identified as barriers and facilitators, but there were differences in the specific thematic factors identified by stakeholders as barriers and facilitators within each of these implementation constructs. The barriers and facilitators that stakeholders identified within each CFIR construct were often connected to their specific role in implementing MBC.ConclusionCollecting information on barriers and facilitators to MBC implementation from the multiple stakeholders involved in the process may enhance successful implementation of MBC given the variation between groups in identified thematic factors. Administrative staff perspectives, which have not been reported in the literature, may be of particular importance in planning for successful MBC implementation.