bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiation therapy for esthesioneuroblastoma: Rationale for elective neck irradiation
Authors: Monroe Alan T. , Hinerman Russell W. , Amdur Robert J. , Morris Christopher G. , Mendenhall William M. 
Published: June 2003

AbstractPurpose.Esthesioneuroblastoma is an uncommon malignancy of neural crest origin arising in the upper nasal cavity. We describe the University of Florida experience using radiation therapy (RT) in the treatment of this neoplasm, particularly the use of elective nodal irradiation.Materials and Methods.Between May 1972 and August 1998, 22 patients received RT for esthesioneuroblastoma. Two additional patients were treated with palliative intent and were excluded from analysis. Equal numbers of male and female patients were treated, with a median age of 54 years (range, 3–82). The modified Kadish stage was A in 1 patient, B in 4 patients, C in 15 patients, and D in 2 patients. Treatment modalities included primary RT in 6 patients, preoperative RT in 1 patient, postoperative RT after craniofacial resection in 12 patients, and salvage RT in 3 patients treated for recurrence after surgery. Elective neck RT was performed in 11 of 20 patients; 2 patients had cervical metastases at presentation for RT.Results.Rates of local control, cause‐specific survival, and absolute survival at 5 years were 59%, 54%, and 48%, respectively. The cause‐specific survival rate at 5 years was lower after primary RT (17%) than after craniofacial resection and postoperative RT (56%). Cervical metastases occurred in 6 of 22 patients (27%). No neck recurrences occurred in 11 patients treated with elective neck RT compared with 4 neck recurrences in 9 patients (44%) not receiving elective neck RT (p = .02).Conclusions.Combined modality therapy is preferred over RT alone in advanced‐stage esthesioneuroblastoma. Our data and review of the current literature suggest a higher cervical failure rate than previously recognized. Elective neck RT seems to correlate with improved nodal control and should be considered in the treatment of esthesioneuroblastoma. © 2003 Wiley Periodicals, Inc. Head Neck 25: 529–534, 2003
Parotid gland surgery: 4‐Year review of 118 cases in an Asian population
Authors: Lim Lynne Hsueh Yee , Chao Siew Shuen , Goh Christopher Hood Keng , Ng Chee Yung , Goh Yau Hong , Khin Lay Wai 
Published: June 2003

AbstractBackground.To determine the presentation and management of parotid lesions requiring excision in a largely Chinese Asian population.Methods.Retrospective study of 118 consecutive parotidectomies.Results.Thirty‐seven percent were Warthin's tumor (WT), 33% pleomorphic adenoma (PA), 21% other benign disease (OBD), and 9% malignant tumor (MT). Mean age was significantly different between benign (51 years) and malignant (40 years) lesions. MT decreased above 50 years, but increased five times with pain and two times with a noninferior pole lesion. Sensitivity of fine‐needle aspiration (FNA) for differentiating benign from MT = 78%, for WT =5 8%, for PA =82%, for OBD = 28%, and for MT = 38%. CT scans did not alter WT management. Facial nerve (FN) paresis was not associated with histology, tumor size, site, or parotidectomy type.Conclusions.This is the first report documenting that most benign parotid tumors are WT and not PA. MT risk is greater in those less than 50 with pain and a noninferior pole lesion. Cystic lesions such as WT require great care in the evaluation of FNA findings. © 2003 Wiley Periodicals, Inc. Head Neck 25: 543–548, 2003
Failure analysis of two Ti‐alloy total hip arthroplasty femoral stems fractured in vivo
Authors: Magnissalis E. A. , Zinelis S. , Karachalios Th. , Hartofilakidis G. 
Published: June 2003

AbstractFailure of total hip arthroplasty femoral stems is a serious clinical complication. Even modern metal alloys and designs sometimes suffer such incidents. The reported study aimed at the investigation of the reasons leading the in vivo fracture of two Ti6Al4V femoral stems. Stems were retrieved during revision surgery approximately 2 years postoperatively. Examination and analysis included XRF spectrometry for identification of chemical composition, macroscopic examination and topographical measurements, SEM study of fracture surfaces, study of alloy microstructure by optical microscopy, and finally measurement of mechanical properties by means of tensile testing conducted on alloy samples machined from the stems themselves. Macroscopic examination and measurements showed close topographical similarity between the two fractures. XRF spectrometry, tensile testing, and microstructure analysis identified the alloy as a typical Ti6Al4V surgical titanium alloy. During SEM analysis the fracture surfaces exhibited characteristic fatigue striations tidally running on the cross sections, which were considered as the weakest ones regarding toward geometry and stress concentration. Fracture in both stems occurred due to fatigue along these cross sections. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 66B: 299–305, 2003
Glutaraldehyde‐fixed kangaroo aortic wall tissue: Histology, crosslink stability and calcification potential
Authors: Neethling W. M. L. , Hodge A. J. , Glancy R. 
Published: June 2003

AbstractStentless aortic heart valve substitutes, manufactured from biological tissues, are fixed with glutaraldehyde to cross‐link collagen, reduce antigenicity, and sterilize the tissue. Despite improved cross linking, reduced antigenicity, and various anticalcification measures, the aortic wall tissue present in these prostheses tends to calcify. The aim of this study was to assess the morphology, collagen cross‐link stability, and calcification potential of glutaraldehyde‐preserved kangaroo aortic wall tissue as opposed to porcine aortic wall tissue. Porcine and kangaroo aortic wall tissues were fixed in 0.625% buffered glutaraldehyde. Histology and cross‐link stability were examined. Calcification potential was determined in the subcutaneous rat model. Kangaroo aortic wall tissue was significantly (p < 0.01) less calcified than porcine aortic wall tissue (26.67 ± 6.53 versus 41.959 ± 2.75 μg/mg tissue) at 8 weeks. In conclusion, the histological differences between kangaroo and porcine aortic wall tissue correlate well with the reduced calcification potential of kangaroo aortic wall tissue. The reduced calcification potential could result in improved long‐term durability of stentless kangaroo heart valves as bioprostheses. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 66B: 356–363, 2003
Novel visible‐light‐induced photocurable tissue adhesive composed of multiply styrene‐derivatized gelatin and poly(ethylene glycol) diacrylate
Authors: Li Cailong , Sajiki Toshinobu , Nakayama Yasuhide , Fukui Masashi , Matsuda Takehisa 
Published: June 2003

AbstractA novel photocurable tissue adhesive glue, which is composed of styrene‐derivatized (styrenated) gelatin, poly(ethylene glycol) diacrylate (PEGDA), and carboxylated camphorquinone in phosphate‐buffered saline (PBS), was prepared. The prototype formulation suitable for arterial repair was determined based on the gel yield, degree of swelling, tissue adhesive strength, and breaking (or burst) strength in vitro. The formulated photocurable tissue adhesive glue with an appropriate viscosity was converted to a water‐swollen gel within 1 min of visible light irradiation. The tissue adhesive glue, which was coated on a rat abdominal aorta incised with a pair of scissors, was immediately converted to a swollen gel upon subsequent irradiation with visible light, and concomitantly hemostasis was completed. Histological examination showed that the produced gel was tightly adhered to the artery shortly after photoirradiation. The gel gradually degraded with time and was completely absorbed within 4 weeks after treatment. These results indicate that the photocurable glue developed here may serve as a tissue adhesive glue applicable to vascular surgery. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 66B: 439–446, 2003
Novel Guglielmi detachable coils (GDCs) for the treatment of brain aneurysms. In vitro study of hydroxyapatite coating on Pt plate as GDCs model
Authors: Matsusaki Michiya , Kamezawa Takashi , Shimozuru Tetsuro , Kuratsu Jun‐ichi , Kishida Akio , Akashi Mitsuru 
Published: June 2003

AbstractWith the use of an alternate soaking process a thin layer of hydroxyapatite (HAp) was formed on a platinum plate (Pt plate) which was used as a model for Guglielmi detachable coils (GDCs). The in vitro coagulant activity of the HAp‐coated Pt plate was evaluated for the purpose of brain aneurysm treatment. In order to fix and to form the apatite layer homogeneously, β‐mercaptopropionic acid was immobilized onto the Pt surface prior to use. The HAp layer was formed on the β‐mercaptopropionic acid‐fixed Pt plate surface, and quantitative control of apatite formation was achieved by controlling the number of alternate soaking process cycles. The HAp formed on the Pt plate surface was confirmed by X‐ray diffraction and X‐ray photoelectron spectroscopy studies. Blood interaction with the Pt plate was altered from nonthrombotic to highly thrombotic by forming a HAp layer on the surface. The alternate soaking process is an appropriate method to modify the GDCs. Complete treatment of brain aneurysms is expected with the use of HAp‐coated GDCs, which would allow formation of a stable blood clot. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 66B: 429–438, 2003
SEM and TEM analysis of water degradation of human dentinal collagen
Authors: Hashimoto Masanori , Tay Franklin R. , Ohno Hiroki , Sano Hidehiko , Kaga Masayuki , Yiu Cincia , Kumagai Hiroshi , Kudou Yoshiyuki , Kubota Minoru , Oguchi Haruhisa 
Published: June 2003

AbstractRecently several long‐term studies have reported evidence of the hydrolytic degradation of collagen fibrils based on fractured surface observations after bond testing. Those studies suggested that one cause of the decline in the bond strength was the degradation of the collagen fibrils within the bonds. However, one concern has been raised that the dentinal collagen fibrils may be stable in water that does not contain oral bacteria or enzymes. Therefore, the present study aimed to clarify the micromorphological change in naked collagen fibrils after 500 days of water storage. To prepare exposed collagen fibrils, sectioned and polished human dentin surfaces were acid conditioned for 15 s with the use of two commercially available acid conditioners: All‐Etch (10% phosphoric acid) and Uni‐Etch (32% phosphoric acid) (Bisco, Inc.). Those specimens were stored in distilled water at 37 °C for 1 day (control) for 500 days. After the storage periods, the samples were examined with the use of SEM and TEM. Under SEM and TEM examination, micromorphological alterations (disarrangement of collagen web, widening the interfibrillar space, and the thinning diameter of collagen fibrils) were found in the specimens after 500 days in water. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 66B: 287–298, 2003
Support sizes of threefold resolvable triple systems
Authors: Chang Yanxun , Faro Giovanni Lo , Shen Hao 
Published: June 2003

AbstractLetSSR(v, 3) denote the set of all integerb* such that there exists aRTS(v, 3) withb* distinct triples. In this paper, we determine the setSSR(v, 3) forv≡ 3 (mod 6) andv≥ 3 with only five undecided cases. We establish thatSSR(v, 3) =P(v, 3) forv≡ 3 (mod 6),v≥ 21 andv≠ 33, 39 whereP(v, 3) = {mv,mv+ 4,mv+ 6,mv+ 7, …, 3mv} andmv, =v(v− 1)/6. As a by‐product, we remove the last two undecided cases for the intersection numbers of Kirkman triple system of order 27, this improves the known result provided in [2]. © 2003 Wiley Periodicals, Inc. J Combin Designs 11: 275–289, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jcd.10037
Some new matrix‐minus‐diagonal V(11,t) vectors
Authors: Abel R. Julian R. 
Published: June 2003

AbstractIn this paper we present the results of a long computer search, which reveal that no V(11, t) vector exists for t ∈ {2, 6, 8, 18}, but exist in all other cases when q = 11t + 1 is a prime less than 5,000. © 2003 Wiley Periodicals, Inc. J Combin Designs 11: 304–306, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jcd.10042
Backtracking algorithm for finding t‐designs
Authors: M‐Noori M. , Tayfeh‐Rezaie B. 
Published: June 2003

AbstractA detailed description of an improved version of backtracking algorithms for finding t‐designs proposed by G. B. Khosrovshahi and the authors of this paper [J Combin Designs 10 (2002), 180–194] is presented. The algorithm is then used to determine all 5‐(14,6,3) designs admitting an automorphism of order 13, 11, or 7. It is concluded that a 5‐(14,6,3) design with an automorphism of prime order p exists if and only if p=2,3,7,13. © 2003 Wiley Periodicals, Inc. J Combin Designs 11: 240–248, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jcd.10045
Exponential number of inequivalent difference sets in ℤ
Authors: Davis James A. , Smeltzer Deirdre L. 
Published: June 2003

AbstractKantor [5] proved an exponential lower bound on the number of pairwise inequivalent difference sets in the elementary abelian group of order 22s+2. Dillon [3] generalized a technique of McFarland [6] to provide a framework for determining the number of inequivalent difference sets in 2‐groups with a large elementary abelian direct factor. In this paper, we consider the opposite end of the spectrum, the rank 2 group ℤ
, and compute an exponential lower bound on the number of pairwise inequivalent difference sets in this group. In the process, we demonstrate that Dillon difference sets in groups ℤ
can be constructed via the recursive construction from [2] and we show that there are exponentially many pairwise inequivalent difference sets that are inequivalent to any Dillon difference set. © 2003 Wiley Periodicals, Inc. J Combin Designs 11: 249–259, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jcd.10046
The smallest minimal blocking sets of Q(6, q), q even
Authors: De Beule J. , Storme L. 
Published: June 2003

AbstractWe characterize the smallest minimal blocking sets of Q(6,q),qeven andq≥ 32. We obtain this result using projection arguments which translate the problem into problems concerning blocking sets of Q(4,q). Then using results on the size of the smallest minimal blocking sets of Q(4,q),qeven, of Eisfeld et al. (2001) Discrete Math 238(1–3): 35–51, and results concerning the number of internal nuclei of (q + 2)‐sets in PG(2,q),qeven, of Bichara and Korchmáros [1982; Note on], we obtain the characterization. © 2003 Wiley Periodicals, Inc. J Combin Designs 11: 290–303, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jcd.10048
The dose—effect relationship in psychotherapy: A defining achievement for Dr. Kenneth Howard
Authors: Kopta S. Mark 
Published: June 2003

AbstractThis article summarizes the Howard, Kopta, Krause, and Orlinsky (1986) study and notes its contributions to the field of psychotherapy. These contributions include (a) being the flagship study to estimate how psychotherapy is enough, (b) establishing number of sessions or dose as the common treatment unit of psychotherapy, (c) providing the first dosage standard for determining treatment groups, (d) inspiring the recent wave of effectiveness research, and (e) presenting the first methodology that assesses the efficiency of psychotherapy. © 2003 Wiley Periodicals, Inc. J Clin Psychol.
Equivalence to normal?
Authors: Newman Frederick L. , Saunders Stephen , Feaster Daniel J. 
Published: June 2003

AbstractThe two articles discussed are integral ingredients of a greater whole Ken Howard envisioned. The first (Saunders, Howard, & Newman, 1988) refined our understanding of clinical significance, challenging researchers to clearly define the character and range of behaviors identified as normal or nonclinical for a specific population. The second (Rogers, Howard, & Vessey, 1993) focused on tests of equivalency between two experimental groups. Both were part of a general theme: A study's outcome requires a careful delineation of the norms and “normality” for that population as well as to whether the differences or equivalencies of the outcomes from these norms are important to the client, to the client's family, or to the community/society in which the client is to function. Ken's second authorship, typical on his many publications, honored his dedication to mentoring those who would improve upon what is currently understood. © 2003 Wiley Periodicals, Inc. J Clin Psychol.
Efficacy, effectiveness, and expected treatment response in psychotherapy
Authors: Lutz Wolfgang 
Published: June 2003

AbstractThis article provides a summary of “The Evaluation of Psychotherapy: Efficacy, Effectiveness, and Patient Progress” (Howard, Moras, Brill, Martinovich, & Lutz, 1996) and an introduction to the “patient profiling” method. First, the difference between the two main approaches to treatment research in psychotherapy, efficacy research and effectiveness research, are discussed. Next, the idea is introduced that both types of treatment‐focused research strategies need to be supplemented by a patient‐focused research strategy. The concept of patient profiling is presented as an application of such a patient‐focused research strategy. The usefulness of patient profiling for monitoring and evaluating individual patients' progress in ongoing psychotherapy as well as for clinical decision making is described. An expression of the personal and professional impact of Ken Howard on the author is provided. © 2003 Wiley Periodicals, Inc. J Clin Psychol.
Couple alcohol treatment benefits patients' partners
Authors: Kuenzler Alfred , Beutler Larry E. 
Published: June 2003

AbstractThis study explored the effects of conjoint therapy on the partner of alcoholic patients. Seventy‐five alcohol abusers were randomly assigned to one of two manualized alcoholism treatments. Effects on partners were evaluated on three outcome measures. Results indicated that partner alcohol use was initially high, but was improved by treatment. An assessment of cross‐cutting dimensions of patient‐treatment matching, found to be effective in predicting patient response, was then applied to the prediction of partner response. These dimensions were unsuccessful in predicting changes in partner response to treatment. Results are discussed in respect to possible differences in matching partners versus clients to treatment. The statistical representation of patient‐treatment matching is discussed along with other topics for future Aptitude × Treatment interaction research. © 2003 Wiley Periodicals, Inc. J Clin Psychol.
Maximal σ‐polynomials of connected 3‐chromatic graphs
Authors: Tomescu Ioan 
Published: June 2003

AbstractIn the set of graphs of order n and chromatic number k the following partial order relation is defined. One says that a graph G is less than a graph H if ci(G) ≤ ci(H) holds for every i, k ≤ i ≤ n and at least one inequality is strict, where ci(G) denotes the number of i‐color partitions of G. In this paper the first ⌈ n/2 ⌉ levels of the diagram of the partially ordered set of connected 3‐chromatic graphs of order n are described. © 2003 Wiley Periodicals, Inc. J Graph Theory 43: 210–222, 2003
The structure of saturated critical blocks
Authors: Nelson Donald A. 
Published: June 2003

AbstractA 2‐connected graph G is a critical block if G − v is not 2‐connected for every vertex v ∈ V(G). A critical block G is a saturated critical block if G + e is not a critical block for any new edge e. The structure of all saturated critical blocks and a procedure for constructing every saturated critical block are determined. © 2003 Wiley Periodicals, Inc. J Graph Theory 43: 223–237, 2003
Tourism in peripheral areas—the challenges for northeast Scotland
Authors: Nash Robert , Martin Andrew 
Published: June 2003

AbstractAll peripheral regions face significant challenges with tourism development. This research initially acknowledges the challenges facing peripheral regions, which can be either geographical, such as access and infrastructure, or perceptual in nature, such as image related. Subsequently the challenges for tourism provision and development in the northeast of Scotland are discussed. Primary data have been collected from tourism providers in the region in an attempt to identify the specific challenges that face northeast Scotland. This region of Scotland faces a unique challenge in that the region effectively has two micro‐economies; Aberdeen city and its surrounding area benefit from the influence of a relatively buoyant oil industry, whereas the more remote areas to the north and west exhibit many peripheral tendencies. This juxtaposition of two contrasting operating environments in a peripheral area highlights the unique challenges for tourism development in this part of the world. Copyright © 2003 John Wiley & Sons, Ltd.
A human ecological approach to tourism interactions
Authors: Fennell David A. , Butler R. W. 
Published: June 2003

AbstractBuilding on the previous work of Budowski, Murphy and Butler, this paper develops a conceptual framework that examines tourism industry relationships from a human ecological perspective. In particular, predation, competition, neutrality and symbiosis are used to illustrate that tourism industry stakeholders (i.e., various types of tourism, operators, local people, and other land users) value and use resources differently and, in doing so, place varying levels of pressure on each other and the resource base. Human ecology is identified and discussed as a field of research that holds potential in strengthening our understanding of tourism's human ecological interactions. Copyright © 2003 John Wiley & Sons, Ltd.
The RAE‐ification of tourism research in the UK
Authors: Tribe John 
Published: June 2003

AbstractWhereas those working on the inside of tourism generally feel that tourism research is making good progress, the 2001 Research Assessment Exercise (RAE) in the UK offered an outsiders' assessment of UK tourism research that was less benign. This paper examines the results and consequences of the RAE based on an examination of the submissions made by UK higher education institutions. It describes the position of tourism in the RAE and focuses on three key issues—structure, outcomes and visibility. It invokes Kuhnian and Foucauldian perspectives to foreground hidden consequences of the RAE (termed RAE‐ification by the author) that threaten the development of UK tourism research. The article concludes that tourism research, finding itself on the periphery of UK research, faces similar problems to those faced by peripheral tourism regions. Copyright © 2003 John Wiley & Sons, Ltd.