bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pendidikan Sebagai Prediktor Pengetahuan Pencegahan Gastritis Pada Warga Binaan Di Kabupaten Tangerang, Provinsi Banten
Authors: Wijayanti Erlina , Putri Zatnika Cantika , Munawarah Munawarah , Dinda Chairunnisyah Nurita , Hafidh Rifqi , Alivia Agustin Rika 
Published: February 2024

Gastritis adalah proses peradangan pada mukosa dan submukosa lambung. Data Kemenkes RI menyebutkan bahwa Indonesia berada pada urutan keempat kasus gastritis tertinggi di dunia. Upaya pencegahan kekambuhan gastritis meliputi modifikasi diet, menghilangkan kebiasaan konsumsi alkohol, memperbanyak olahraga, dan manajemen stress. Pengetahuan menjadi bagian penting dalam upaya pencegahan gastritis. Penelitian ini bertujuan untuk mengetahui prediktor pengetahuan tentang pencegahan gastritis di Desa Koper, Kecamatan Kresek, Kabupaten Tangerang, Provinsi Banten. Penelitian ini bersifat analitik observasional dengan rancangan penelitian studi cross-sectional. Pengambilan sampel menggunakan teknik quota sampling. Metode analisis yang digunakan adalah analisis univariat dan bivariat. Sampel penelitian sebanyak 36 responden. Pada penelitian ini didapatkan 9 responden memiliki tingkat pengetahuan baik dan 27 responden memiliki tingkat pengetahuan cukup/buruk. Variabel yang dapat memprediksi pengetahuan pencegahan grastritis adalah tingkat pendidikan (p=0,013). Oleh karenanya, diperlukan cara/metode dan media edukasi yang sesuai dengan pendidikan responden sehingga dapat meningkatkan pengetahuan pencegahan gastritis secara lebih efektif.
KRİPTO PARALARIN HACZİ
Authors: AYMAZ Ahmet 
Published: February 2024

TÜRKÇE ÖZET
Kripto paralar, Bitcoin alım satım işlemlerinin başladığı 2009 yılından beri hayatımızın içindedir. İnsanlar arasında kripto para kullanımı hızla artmaktadır. Türk Hukuk’unda kripto paraların hukuki niteliği ayrı bir kanun ile belirlenmiş değildir.
Çalışmamızda kripto paraların hukuki niteliği bakımından kişisel kanaatlerimizi, benzer kavramlar ile karşılaştırarak belirtmeye çalışacağız. Kripto paraların, hukuki niteliğindeki belirsizliğin boyutunun takip hukuku bakımından haczine engel olmadığını göstereceğiz. Kripto paraların icra hukukunda hangi takip yollarına konu edilebileceğine ilişkin kanaatlerimizi belirteceğiz. Haczedilen kripto paralara uygulanabilecek güvenlik tedbirlerini değerlendireceğiz ve bu konuda bazı öneriler sunacağız.
Hukuki nitelik bakımından kanaatimizi kısa bir şekilde belirteceğiz. Sonra, “parasal değeri olan şeylerin haczi mümkündür” bilgisinden hareketle kripto para haczinin Türk Hukuk’unda nasıl gerçekleştirilebileceği hakkında kanaatlerimizi belirteceğiz. Kripto paralara ilişkin, uygulamada karşılaşılacak problemlerde kıyas yolu bir çözüm önerisi olarak inceleyeceğiz ve bu sırada kanun değişiklikleri hakkında görüşlerimizi de belirteceğiz.
Çalışmada kripto paraların hukuki niteliği hakkında kanaatlerimizi belirtebilmek için zaruri gördüğümüz ölçüde maddi hukuk (eşya hukuku) ve iktisadi açıklamalara gireceğiz. Çalışmamızda, konumuz takip hukuku sınırları içerisinde kalmaya çalışacağız.
IMPLEMENTATION OF ASSESSMENT CENTERS IN HUMAN RESOURCE GOVERNANCE AT SIDOARJO REGIONAL GENERAL HOSPITAL
Authors: Indrayana Samuel Indrayana , Kurniawan Bagus Ananda 
Published: February 2024

Abstrak
Tidak semua pegawai RSUD Sidoarjo terlebih pegawai tidak tetap memiliki kompetensi sesuai bidang pekerjaan di RSUD Sidoarjo. Hal tersebut dapat terjadi karena bahwa setiap pegawai berpotensi terjadi dinamika kompetensi, kinerja, dan bakat yang fluktuatif. Oleh karena itu, setiap pegawai tersebut perlu adanya maintenance untuk menjaga kualitas kerja pegawai. Tujuan dilakukan penelitian adalah untuk mengetahui penerapan metode assessment center yang tepat dalam tata kelola SDM di RSUD Sidoarjo. Penelitian ini dianalisis dengan analisis data model Miles, Huberman dan Saldana yang terdiri dari kondensasi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan penerapan metode assessment center yang tepat dalam tata kelola SDM di RSUD Sidoarjo yakni dengan tes tertulis dan wawancara serta penilaian oleh tim penilai untuk mengamati perilaku, keterampilan dan kemampuan peserta. Hasil penelitian juga menunjukkan bahwa kendala penerapan assessment center dalam tata kelola SDM di RSUD Sidoarjo yakni waktu, anggaran dan keterbatasan penilaian terhadap kinerja nyata pegawai.
Kata Kunci:Assessment Center, Pegawai, Tata Kelola SDM
Effect of on-pump vs. off-pump coronary artery bypass grafting in patients with non-dialysis-dependent severe renal impairment: propensity-matched analysis from the UK registry dataset
Authors: Fudulu Daniel P. , Argyriou Amerikos , Kota Rahul , Chan Jeremy , Vohra Hunaid , Caputo Massimo , Zakkar Mustafa , Angelini Gianni D. 
Published: February 2024

IntroductionOn-pump coronary artery bypass (ONCABG) grafting in patients with a pre-existing poor renal reserve is known to carry significant morbidity and mortality. There is limited controversial evidence on the benefit of off-pump coronary artery bypass (OPCABG) grafting in these high-risk groups of patients. We compared early clinical outcomes in propensity-matched cohorts of patients with non-dialysis-dependent pre-operative severe renal impairment undergoing OPCABG vs. ONCABG, captured in a large national registry dataset.MethodsAll data for patients with a pre-operative creatinine clearance of less than 50 mL/min who underwent elective or urgent isolated OPCABG or ONCABG from 1996 to 2019 were extracted from the UK National Adult Cardiac Surgery Audit (NACSA) database. Propensity score matching was performed using 1:1 nearest neighbor matching without replacement using several baseline characteristics. We investigated the effect of ONCABG vs. OPCABG in the matched cohort using cluster-robust standard error regression.ResultsWe identified 8,628 patients with severe renal impairment undergoing isolated CABG, of whom 1,142 (13.23%) underwent OPCABG during the study period. We compared 1,141 propensity-matched pairs of patients undergoing OPCABG vs. ONCABG. The median age of the matched population was 78 years in both groups, with no significant imbalance post-matching in the rest of the variables. There was no difference between OPCABG and ONCABG in in-hospital mortality rates, post-operative dialysis, and stroke rates. However, the return to theatre for bleeding or tamponade was higher in ONCABG vs. OPCABG (P &gt; 0.02); however, OPCABG reduced the total length of stay in the hospital by 1 day (P = 0.008). After double adjustment in the matched population using cluster-robust standard regression, ONCABG did not increase mortality compared to OPCABG (OR, 1.05, P = 0.78), postoperative stroke (OR, 1.7, P = 0.12), and dialysis (OR, 0.7, P = 0.09); however, ONCABG was associated with an increased risk of bleeding (OR, 1.53, P = 0.03).DiscussionIn this propensity analysis of a large national registry dataset, we found no difference in early mortality and stroke in patients with pre-operative severe renal impairment undergoing OPCABG or ONCABG surgery; however, ONCABG was associated with an increased risk of return to theatre for bleeding and an increased length of hospital stay.
Measuring mental health action competencies in school teachers: internal and external validity evidence
Authors: Kerry Matthew J. , Robin Dominik , Albermann Kurt , Dratva Julia 
Published: February 2024

IntroductionMental health literacy is receiving increasing research attention due to growing concerns for mental health globally. Among children, teachers have recently been recognized as playing a vital role in the recognition and reporting of potential mental health issues.MethodsA nationally sampled cross-section of teachers was surveyed to examine the discriminant validity of the mental health literacy measure across levels of teaching. A survey collected a total of n = 369 teacher responses in Switzerland (Kindergarten = 76, Primary = 210, Secondary = 83). Item response theory (IRT) analyses were conducted.ResultsInspection of psychometric properties indicated removal of two weak performing items. The 15-item measure exhibited a significant mean difference, such that class-responsibility function scored higher (M = 2.86, SD = .45) than non-responsible function (M = 2.68, SD = .45) teachers [t(309) = −2.20, p = .01]. It also exhibited a significant mean difference, such that more subjective experienced scored higher (M = 2.86, SD = .45) than less subjective experienced (M = 2.68, SD = .45) teachers [t(210) = −8.66, p &lt; .01].DiscussionHypotheses regarding age and role tenure were in the expected direction, but non-significant. The MHL measure for teachers demonstrated sound measurement properties supporting usage across teaching levels.
Eliciting perspectives on remote healthcare delivery from service users with psychosis in the community: a cross-sectional survey study
Authors: Kuhn Ronja , Abdel-Halim Nadia , Healey Patrick , Bird Victoria , Elliot Kathryn , McNamee Philip 
Published: February 2024

IntroductionThe transition towards remote healthcare has been rapidly accelerated in recent years due to a number of factors, including the COVID-19 pandemic, however, few studies have explored service users' views of remote mental healthcare, particularly in community mental health settings.MethodsAs part of a larger study concerned with the development of a remotely delivered psychosocial intervention, a survey was conducted with service users with psychosis (N = 200) from six NHS trusts across England to gain cross-sectional data about service users' opinions and attitudes towards remote interventions and explore how digital access varies across different demographic groups and geographical localities.ResultsThe majority of service users had access to technological devices and a quiet space to receive care. Age was a key factor in motivation to engage with remote care as older participants had less access to technological devices and the internet, and reported less confidence to learn how to use new technologies compared to younger participants. Differences in access and attitudes towards remote care were found across the different geographical localities. Over half of the participants (53.1%) preferred a hybrid model (i.e., mixture of face-to-face and remotely delivered treatment), with only 4.5% preferring remote treatment exclusively. Factors that both encourage and deter service users from engaging with remote care were identified.ConclusionsThe findings of this study provide important information about the environmental and clinical barriers that prevent, or limit, the uptake of remotely delivered care for people with psychotic disorders. Although service users often have the ability and capacity to receive remote care, providers need to be cognisant of factors which may exacerbate digital exclusion and negatively impact the therapeutic alliance.
The HBCU advantage: reimagining social capital among students attending black colleges
Authors: Johnson Jennifer M. , Jackson Elizabeth 
Published: February 2024

IntroductionThere is growing interest in exploring the ways Historically Black Colleges and Universities (HBCUs) mediate student outcomes.MethodsSituating an HBCU education within the conceptual landscape of social capital, we follow the tenets of critical discourse analysis (CDA) to explore the narratives of ten early and mid-career HBCU alumni of eight 4-year colleges and universities. This framing allows for a nuanced analysis of the ways in which an HBCU education provides its students the opportunity to curate social capital in an environment that affirms racial identity and promotes continued service to the Black community.ResultsFindings support the notion that as purveyors of social capital, HBCUs facilitate the transmission of knowledge through relationships and networks that strengthen community ties and leads to educational and professional gains.DiscussionThese findings inform our understanding of the experiences, policies, and practices that promote community building and the successful career transitions among Black college graduates.
Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases
Authors: Qian Zonghao , Huang Yuzhen , Zhang Yucong , Yang Ni , Fang Ziwei , Zhang Cuntai , Zhang Le 
Published: February 2024

Background: Physical weakness and cardiovascular risk increase significantly with age, but the underlying biological mechanisms remain largely unknown. This study aims to reveal the causal effect of circulating metabolites on frailty, sarcopenia and vascular aging related traits and diseases through a two-sample Mendelian Randomization (MR) analysis.Methods: Exposures were 486 metabolites analyzed in a genome-wide association study (GWAS), while outcomes included frailty, sarcopenia, arterial stiffness, atherosclerosis, peripheral vascular disease (PAD) and aortic aneurysm. Primary causal estimates were calculated using the inverse-variance weighted (IVW) method. Methods including MR Egger, weighted median, Q-test, and leave-one-out analysis were used for the sensitive analysis.Results: A total of 125 suggestive causative associations between metabolites and outcomes were identified. Seven strong causal links were ultimately identified between six metabolites (kynurenine, pentadecanoate (15:0), 1-arachidonoylglycerophosphocholine, androsterone sulfate, glycine and mannose) and three diseases (sarcopenia, PAD and atherosclerosis). Besides, metabolic pathway analysis identified 13 significant metabolic pathways in 6 age-related diseases. Furthermore, the metabolite-gene interaction networks were constructed.Conclusion: Our research suggested new evidence of the relationship between identified metabolites and 6 age-related diseases, which may hold promise as valuable biomarkers.
Evaluation of the neuroprotective efficacy of the gramine derivative ITH12657 against NMDA-induced excitotoxicity in the rat retina
Authors: Di Pierdomenico Johnny , Gallego-Ortega Alejandro , Norte-Muñoz María , Vidal-Villegas Beatriz , Bravo Isaac , Boluda-Ruiz María , Bernal-Garro Jose Manuel , Fernandez-Bueno Iván , Pastor-Jimeno Jose Carlos , Villegas-Pérez María Paz , Avilés-Trigueros Marcelino , de los Ríos Cristobal , Vidal-Sanz Manuel 
Published: February 2024

PurposeThe aim of this study was to investigate, the neuroprotective effects of a new Gramine derivative named: ITH12657, in a model of retinal excitotoxicity induced by intravitreal injection of NMDA.MethodsAdult Sprague Dawley rats received an intravitreal injection of 100 mM NMDA in their left eye and were treated daily with subcutaneous injections of ITH12657 or vehicle. The best dose–response, therapeutic window study, and optimal treatment duration of ITH12657 were studied. Based on the best survival of Brn3a + RGCs obtained from the above-mentioned studies, the protective effects of ITH12657 were studied in vivo (retinal thickness and full-field Electroretinography), and ex vivo by quantifying the surviving population of Brn3a + RGCs, αRGCs and their subtypes α-ONsRGCs, α-ONtRGCs, and α-OFFRGCs.ResultsAdministration of 10 mg/kg ITH12657, starting 12 h before NMDA injection and dispensed for 3 days, resulted in the best significant protection of Brn3a + RGCs against NMDA-induced excitotoxicity. In vivo, ITH12657-treated rats showed significant preservation of retinal thickness and functional protection against NMDA-induced retinal excitotoxicity. Ex vivo results showed that ITH12657 afforded a significant protection against NMDA-induced excitotoxicity for the populations of Brn3a + RGC, αRGC, and αONs-RGC, but not for the population of αOFF-RGC, while the population of α-ONtRGC was fully resistant to NMDA-induced excitotoxicity.ConclusionSubcutaneous administration of ITH12657 at 10 mg/kg, initiated 12 h before NMDA-induced retinal injury and continued for 3 days, resulted in the best protection of Brn3a + RGCs, αRGC, and αONs-RGC against excitotoxicity-induced RGC death. The population of αOFF-RGCs was extremely sensitive while α-ONtRGCs were fully resistant to NMDA-induced excitotoxicity.
Endoscopic endonasal transsphenoidal surgery for unusual sellar lesions: eight cases and review of the literature
Authors: Wu Jiandong , Deng Peng , Qian Jinhong , Lu Yanli , Ding Zhiliang , Hu Xiaolong , Gong Yuhui , Tang Xiaoyu , Ma Mian 
Published: February 2024

BackgroundPreoperative imaging for some unusual lesions in the sellar region can pose challenges in establishing a definitive diagnosis, impacting treatment strategies.MethodsThis study is a retrospective analysis of eight cases involving unusual sellar region lesions, all treated with endoscopic endonasal transsphenoidal surgery (EETS). We present the clinical, endocrine, and radiological characteristics, along with the outcomes of these cases.ResultsAmong the eight cases, the lesions were identified as follows: Solitary fibrous tumor (SFT) in one case, Lymphocytic hypophysitis (LYH) in one case, Cavernous sinus hemangiomas (CSH) in one case, Ossifying fibroma (OF) in two cases; Sphenoid sinus mucocele (SSM) in one case, Pituitary abscess (PA) in two cases. All patients underwent successful EETS, and their diagnoses were confirmed through pathological examination. Postoperatively, all patients had uneventful recoveries without occurrences of diabetes insipidus or visual impairment.ConclusionOur study retrospectively analyzed eight unusual lesions of the sellar region. Some lesions exhibit specific imaging characteristics and clinical details that can aid in preoperative diagnosis and inform treatment strategies for these unusual sellar diseases.
Mammary epithelium permeability during established lactation: associations with cytokine levels in human milk
Authors: Kivlighan Katie T. , Schneider Sallie S. , Browne Eva P. , Pentecost Brian T. , Anderton Douglas L. , Arcaro Kathleen F. 
Published: February 2024

ObjectiveThe cytokine profile of human milk may be a key indicator of mammary gland health and has been linked to infant nutrition, growth, and immune system development. The current study examines the extent to which mammary epithelium permeability (MEP) is associated with cytokine profiles during established lactation within a sample of US mothers.MethodsParticipants were drawn from a previous study of human milk cytokines. The present analysis includes 162 participants (98 Black, 64 White) with infants ranging from 1 to 18 months of age. Levels of cytokines were determined previously. Here we measure milk sodium (Na) and potassium (K) levels with ion-selective probes. Two approaches were used to define elevated MEP: Na levels ≥10 mmol/L and Na/K ratios greater than 0.6. Associations between maternal–infant characteristics, elevated MEP, and twelve analytes (IL-6, IL-8, TNFα, IL-1β, FASL, VEGFD, FLT1, bFGF, PLGF, EGF, leptin, adiponectin) were examined using bivariate associations, principal components analysis, and multivariable logistic regression models.ResultsElevated MEP was observed in 12 and 15% of milk samples as defined by Na and Na/K cutoffs, respectively. The odds of experiencing elevated MEP (defined by Na ≥ 10 mmol/L) were higher among Black participants and declined with older infant age. All cytokines, except leptin, were positively correlated with either Na or the Na/K ratio. A pro-inflammatory factor (IL-6, IL-8, TNFα, IL-1β, EGF) and a tissue remodeling factor (FASL, VEGFD, FLT1, bFGF, PLGF, adiponectin) each contributed uniquely to raising the odds of elevated MEP as defined by either Na or the Na/K ratio.ConclusionThis exploratory analysis of MEP and cytokine levels during established lactation indicates that elevated MEP may be more common in US populations than previously appreciated and that individuals identifying as Black may have increased odds of experiencing elevated MEP based on current definitions. Research aimed at understanding the role of MEP in mammary gland health or infant growth and development should be prioritized.
Challenges in treating children with optic pathway gliomas: an 18-year experience from a middle-income country
Authors: Ramírez-Melo Jorge Luis , Moreira Daniel C. , Orozco-Alvarado Ana Luisa , Sánchez-Zubieta Fernando , Navarro-Martín del Campo Regina M. 
Published: February 2024

IntroductionPatients with optic pathway gliomas (OPG) have good survival rates although their long-term quality of life can be affected by the tumor or treatment-related morbidity. This retrospective study sought to describe the clinical presentation and outcomes of children with OPG at a tertiary center in Mexico.MethodsConsecutive patients &lt;18 years-of-age with newly diagnosed OPG between January 2002 and December 2020 at the Hospital Civil de Guadalajara Dr. Juan I. Menchaca in Guadalajara, Mexico were included.ResultsThirty patients were identified with a median age of six years. The most frequent clinical manifestations were loss of visual acuity (40%) and headaches (23%). Neurofibromatosis-1 was found in 23.3% of the patients. Surgery, either biopsy or resection, was done in 20 of 30 patients. Two patients died shortly after initial surgery. The 5-year event-free survival (EFS) was 79.3% ± 10.8% and the 5-year overall survival was 89.5% ± 6.9%. Lower EFS was associated with age less than 3 years, intracranial hypertension at presentation, and diencephalic syndrome. Patients who received surgery as first-line treatment had a 3.1 times greater risk of achieving a performance score of less than 90 points at 6 months after diagnosis (p=0.006). Of 10 patients with vision testing, 5 had improvement in visual acuity, 4 had no changes, and one patient showed worsening.ConclusionOur data suggests that favorable outcomes can be achieved with OPG in low- and middle-income countries, although a high rate of surgical complications was described leading to a lower overall survival. These data can be used prospectively to optimize treatment at this institute and other middle-income countries through a comprehensive, multidisciplinary approach.
Melittin promotes dexamethasone in the treatment of adjuvant rheumatoid arthritis in rats
Authors: Yang Linfu , He Xiying , Zhi Dandan , Xue Yunfei , Gong Xueyang , Dong Kun , Tian Yakai 
Published: February 2024

Background: Rheumatoid arthritis (RA) is an erosive-destructive inflammation of the joints, and the chronic, long-term stiffness and deformation induced by RA are some of the symptoms of arthritis that are difficult to treat. Dexamethasone (DEX) and melittin (MLT) are two interesting anti-inflammatory substances, both of which possess anti-inflammatory effects exerted through the suppression of the immune system. The purpose of this study was to explore the role of MLT in the treatment of RA by DEX as well as to clarify the influence of MLT on the efficacy and side effects of DEX.Method: The rats were injected with Complete Freund’s Adjuvant (CFA) to induce arthritis, followed by treatment with different doses of DEX and/or MLT. The relevant indexes of paw inflammation were determined, and the appetite, growth status, arthritis status, cytokine levels, and organ coefficient of the rats were evaluated. In addition, the paraffin sections of the joint tissues were prepared to analyze the pathological changes.Result: DEX exhibited side effects, notably hindering feed intake and growth, and inducing immune organ lesions in the rats. MLT significantly reduced the side effects of DEX and promoted its efficacy. DEX in combination with MLT demonstrated a synergistic efficacy in RA treatment, showing advantages in detumescence reduction, pro-inflammatory cytokine inhibition, and joint internal pathological improvement.Conclusion: Thus, MLT promoted the efficacy of DEX in adjuvant RA treatment in rats, offering an approach to reduce the use dosage and side effects of DEX.