bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of low pharyngeal/esophageal pressure associated with sarcopenia on postendoscopic submucosal dissection pneumonia in patients with superficial esophageal cancer
Authors: Taniguchi Yasuhiro , Ono Junki , Haraguchi Masafumi , Tabuchi Maiko , Hisamatsu Noriko , Takahata Hideaki , Kondo Hisayoshi , Yamaguchi Naoyuki , Kumai Yoshihiko , Nakao Kazuhiko 
Published: November 2023

ObjectivesThe aging population, including patients with superficial esophageal cancer, encounters critical dysphagia‐ and postoperative pneumonia‐related issues. Although endoscopic submucosal dissection (ESD) provides advantages over other modalities, older patients are at higher risk of postoperative pneumonia. Furthermore, the etiologies of pneumonia are complex and include patient‐ (such as sarcopenia) and treatment‐ (including ESD) related factors. Therefore, this study evaluated swallowing function in patients with superficial esophageal cancer and identified post‐ESD pneumonia‐associated factors.MethodsComprehensive swallowing function and sarcopenia were evaluated in patients pre‐ESD and 2 months post‐ESD using high‐resolution manometry and several swallowing studies by multiple experts. The effects of mucosal resection and sarcopenia on swallowing function changes post‐ESD, the relationship between preoperative swallowing function and sarcopenia, and the factors influencing postoperative pneumonia were investigated.ResultsTwenty patients were included in the study. Patients with preoperative sarcopenia had significantly lower pharyngeal/upper esophageal sphincter and tongue pressures than those without sarcopenia. However, ESD did not worsen pharyngeal or upper esophageal pressure. Post‐ESD pneumonia incidence tended to be higher in patients with sarcopenia than in those without sarcopenia. The lower upper esophageal sphincter‐integrated relaxation pressure (UES‐IRP) was a significant factor in pneumonia development. Furthermore, the receiver operating characteristic curve for UES‐IRP in pneumonia yielded an area under the curve of 0.82.ConclusionsSarcopenia is associated with preoperative dysphagia, which increases post‐ESD pneumonia risk. Therefore, postoperative pneumonia incidence is expected to increase with an aging population, making preoperative sarcopenia and swallowing function evaluation crucial.
Preclinical motor chunking and fine motor skill learning in fixed prosthodontics: Contribution of3Dprinting and satisfaction of dental students
Authors: Galibourg Antoine , Vergnes Jean‐Noel , Rattier Robin , Hourset Mathilde , Broutin Margaux , Dusseau Xavier , Bataille Coralie , Nabet Catherine , Esclassan Rémi 
Published: November 2023

AbstractIntroductionIn fixed prosthodontics, simulators are essential to students for a progressive transition from preclinical to clinical condition. With the 3D printing technology, we developed resin bars allowing students to better visualise by motor chunking technique. Main objectives of this work were to describe this teaching methodology used in preclinic among different promotions of second, third and fourth dental years and to evaluate students' feedback.Materials and MethodsTwo hundred seventy resin strips were digitally designed and printed in resin. All participants from second, third and fourth had to fulfil a User Experience Questionnaire (UEQ) after the preclinical work. The scales of this questionnaire covered the complete impression of the user experience. Both classical aspects of usability (efficiency, insight and reliability) and aspects of user experience (originality, stimulation) were measured.ResultsFor the second dental years, ‘Attractiveness’, ‘Stimulation’ and ‘Novelty’ were considered ‘Excellent’. For the third dental year, novelty average was considered as ‘Excellent’. For the fourth dental year, ‘novelty’ was considered as ‘Good’.DiscussionThe resin plates used in this study are original and stimulating for the students, especially for the second‐year dental students who found the exercises useful for their learning. This method can also be used by creating scenarios close to the clinical situations encountered in dentistry departments (more dilapidated teeth, preparation of inlays, post and core, etc.). This 3D printed simulation model is not intended to replace the Frasaco® models but is a complement to the learning process.
What motivates young Arab Muslim women to choose nursing as a profession: A cross‐sectional study
Authors: Ben Natan Merav , Abd El Hadi Miriam , Zoubi Fardus 
Published: November 2023

AbstractAimThis study examines the impact of nurse uniforms, the coronavirus pandemic, and the image of nurses and the nursing profession on the career choice of young Muslim Arab women in nursing, with a focus on policy implications.BackgroundThe global nursing shortage poses significant challenges, including in Israel. Attracting young Muslim Arab women to nursing careers is vital. Understanding how nurse uniforms, the pandemic, and perceptions of nurses and the nursing profession shape their career decisions can inform policy interventions.MethodsA cross‐sectional study utilized digital questionnaires administered to 200 Muslim Arab women aged 20–30 in Israel. The study adhered to the EQUATOR checklist for cross‐sectional studies.ResultsOnly 29.2% of participants expressed interest in studying nursing. Findings revealed a positive correlation between the pandemic's impact and intention to pursue nursing. A linear regression analysis shows the impact of the white uniform, the image of nurses, and the image of the profession on the choice of a career in nursing.DiscussionThe study emphasizes the significance of nurse uniforms, the image of nurses, and the image of the nursing profession in shaping young Muslim Arab women's career choices in nursing. Policy interventions should raise awareness about nursing roles, expand responsibilities, and highlight nurses' contributions to society.ConclusionStrategies to attract young Muslim Arab women to nursing careers should address nurse uniforms, the image of nurses, and the image of the nursing profession.Implications for policyPolicy interventions should prioritize diversity, promote positive images of nurses and the nursing profession, and raise awareness of nursing roles and contributions among young Muslim Arab women.
The impact of job burnout on nurses' caring behaviors: Exploring the mediating role of work engagement and job motivation
Authors: Labrague Leodoro J. 
Published: November 2023

AbstractAimTo investigate the influence of job burnout on nurses' caring behaviors, with a specific focus on the serial mediating role of work engagement and job motivation.BackgroundJob burnout is a prevalent issue among nurses and poses significant challenges to their ability to deliver compassionate care. However, the underlying mechanisms that explain the relationship between job burnout and nurses' caring behaviors, which could provide valuable insights for developing targeted interventions and strategies to support nurse well‐being and ensure the consistent provision of compassionate care, remain underexplored.MethodsA cross‐sectional design was used to gather data from 520 clinical nurses working in various acute healthcare settings in the Philippines. Mediation analyses were conducted using the PROCESS Macro with Model 6.ResultsNurses exhibited high levels of caring behaviors (M = 4.219); however, they experienced moderate levels of job burnout (M = 2.342). Job burnout had a negative effect (β = −0.0603, p = 0.0482) on nurses’ caring behaviors. Work engagement and job motivation sequentially mediated the relationship between job burnout and nurse caring behaviors (β = −0.0126, p < 0.05).ConclusionsHigher levels of job burnout were associated with a decreased demonstration of nurses' caring behaviors. Job burnout among nurses led to a decrease in their level of work engagement and job motivation, ultimately impacting their ability to provide caring behaviors to patients.Implications for nursing and health policyOrganizations should prioritize creating a positive work environment and implementing theory‐driven strategies to address job burnout, which can foster work engagement and job motivation among nurses, thereby providing crucial support for them in delivering high‐quality, compassionate care to patients.
Optimal pricing strategies of e‐commerce supply chain considering consumers’ anticipated regrets under the background of blockchain anti‐counterfeiting technology
Authors: Yu Tianyang , Guan Zhimin , Li Jin , Zhang Jun , Dong Jingyang 
Published: November 2023

AbstractIn this study, we investigate pricing decisions with different decision sequences in an e‐commerce supply chain. The e‐commerce platform sells blockchain‐compatible products through a self‐operated model, while the retailer operating on the platform sells general products. Furthermore, we take into account the impact of counterfeits infiltrating the general product market. This can trigger consumers’ anticipated regrets, including high‐price regret and fake purchase regret. We design three scenarios: Scenario ES (the e‐commerce platform makes the decision first), Scenario RS (the retailer makes the decision first), and Scenario VN (they make decisions simultaneously). We study the impact of consumers’ anticipated regrets and the decision sequence on pricing strategies, as well as the profits of the e‐commerce platform and the retailer. Our results show that the optimal retail prices of the two versions of the products and the profits of the e‐commerce platform and the retailer are negatively correlated with the relative regret intensity. The profits of the e‐commerce platform and the retailer are the lowest under Scenario VN due to the fiercest competition. The e‐commerce platform prefers Scenario RS to Scenario ES. If the counterfeit penetration rate is small and the commission rate is large, the retailer prefers Scenario RS to Scenario ES. However, if the counterfeit penetration rate is high, or if both the counterfeit penetration rate and the commission rate are low, the retailer prefers Scenario ES to Scenario RS. Furthermore, if government penalties (or consumer claims) exist, the retailer should combat counterfeiting appropriately for better financial performance.
Epigenetic patterns in Atlantic herring (Clupea harengus): Temperature and photoperiod as environmental stressors during larval development
Authors: Kho J. , Delgado M. L. , McCracken G. R. , Munden J. , Ruzzante D. E. 
Published: November 2023

AbstractUnderstanding the molecular mechanisms underlying individual responses to environmental changes is crucial for species conservation and management. Pelagic fishes including Atlantic herring (Clupea harengus) are of particular interest because of their key ecological and economic roles and their susceptibility to a changing ocean from global warming. Temperature and photoperiod have been linked with spawning time and location in adult herring, but no study has thus far investigated the role of environmental factors on gene regulation during the vulnerable early developmental stages. Here, we examine DNA methylation patterns of larval herring bred under two temperatures (11°C and 13°C) and photoperiod (6 and 12 h) regimes in a 2 × 2 factorial design. We found consistently high levels of global methylation across all individuals and a decline in global methylation with increased developmental stage that was more pronounced at 13°C (p ≤ 0.007) than at 11°C (p ≥ 0.21). Most of the differentially methylated sites were in exon and promoter regions for genes linked to metabolism and development, some of which were hypermethylated at higher temperature. These results demonstrate the important role of DNA methylation during larval development and suggest that this molecular mechanism might be key in regulating early‐stage responses to environmental stressors in Atlantic herring.
Dos Crisis En Diez Años
Authors: Baylos Antonio 
Published: November 2023

El articulo contribuye a la cartografía de los debates sobre las reformas y contrarreformas laborales, teniendo en cuenta la reforma laboral española estructurada en torno al RDL 32/2021, y en general al proceso de cambios normativos a partir de marzo del 2020, en plena crisis del COVID, hasta el momento actual en el que se ha producido un desplazamiento del momento post crisis tras la pandemia a la policrisis en la que está inmerso el espacio europeo a partir de febrero del 2022 con el inicio de la guerra en Ucrania y la crisis energética y de suministros consiguiente, que ha provocado el dispararse de la inflación y, hasta el momento, el inicio de una nueva crisis financiera que por el momento no ha repercutido en el espacio monetario del euro. Estudia los dos ciclos de reformas contrapuestas en la regulación de las relaciones laborales. Problematiza los temas referentes a necesidad y excepcionalidad en los dos ciclos de reformas. Y examina la interpretación de la reforma y la mediación de los sujetos que la aplican.
PALABRAS CLAVE: Derecho laboral; Reforma laboral; Reformas laborales españolas.
Digitalización Y Poder De Dirección En La Empresa: Entre La Distopía Y La Acción Sindical
Authors: Gómes Gordillo Rafael 
Published: November 2023

El impacto de la digitalización en el sistema de relaciones laborales está siendo objeto de una intensa atención por estudios de distintas disciplinas y desde ópticas diversas. La mayoría de estos trabajos parten de una premisa globalmente aceptada: los notables avances en las técnicas de recogida, tratamiento y análisis de datos mediante fórmulas algorítmicas o desarrollos de inteligencia artificial permiten facilitar la adopción automatizada de decisiones de gestión empresarial, tanto en las empresas que se organizan en forma de plataformas digitales como en las que se estructuran mediante fórmulas más tradicionales. Si, hace algunos años, la distopía laboral se anunciaba en forma de empresa megadescentralizada, que no necesita contratar directamente a ninguna persona porque todas sus actividades han sido externalizadas, en la actualidad, las amenazas futuristas tienen que ver con la posibilidad de eliminar también el concurso de personas trabajadoras en la empresa mediante la robotización de todas las tareas. Esta tendencia alcanza también a las labores de gestión de recursos humanos. El artículo estudia y propone fórmulas de control sindical del uso de estas tecnologías en el ejercicio de los poderes empresariales, con el objetivo de garantizar el goce de los derechos reconocidos a las personas trabajadoras.

PALABRAS CLAVE: Poder de dirección en la empresa; gestión automatizada; inteligencia artificial; algoritmos; participación sindical en el centro de trabajo.
Heterologous expression of a fully active
Azotobacter vinelandii
nitrogenase Fe protein in
Escherichia coli
Authors: Solomon Joseph B. , Liu Yiling A. , Górecki Kamil , Quechol Robert , Lee Chi Chung , Jasniewski Andrew J. , Hu Yilin , Ribbe Markus W. 
Published: November 2023

ABSTRACT

The functional versatility of the Fe protein, the reductase component of nitrogenase, makes it an appealing target for heterologous expression, which could facilitate future biotechnological adaptations of nitrogenase-based production of valuable chemical commodities. Yet, the heterologous synthesis of a fully active Fe protein of
Azotobacter vinelandii
(
Av
NifH) in
Escherichia coli
has proven to be a challenging task. Here, we report the successful synthesis of a fully active
Av
NifH protein upon co-expression of this protein with
Av
IscS/U and
Av
NifM in
E. coli
. Our metal, activity, electron paramagnetic resonance, and X-ray absorption spectroscopy/extended X-ray absorption fine structure (EXAFS) data demonstrate that the heterologously expressed
Av
NifH protein has a high [Fe
4
S
4
] cluster content and is fully functional in nitrogenase catalysis and assembly. Moreover, our phylogenetic analyses and structural predictions suggest that
Av
NifM could serve as a chaperone and assist the maturation of a cluster-replete
Av
NifH protein. Given the crucial importance of the Fe protein for the functionality of nitrogenase, this work establishes an effective framework for developing a heterologous expression system of the complete, two-component nitrogenase system; additionally, it provides a useful tool for further exploring the intricate biosynthetic mechanism of this structurally unique and functionally important metalloenzyme.

IMPORTANCE

The heterologous expression of a fully active
Azotobacter vinelandii
Fe protein (AvNifH) has never been accomplished. Given the functional importance of this protein in nitrogenase catalysis and assembly, the successful expression of AvNifH in
Escherichia coli
as reported herein supplies a key element for the further development of heterologous expression systems that explore the catalytic versatility of the Fe protein, either on its own or as a key component of nitrogenase, for nitrogenase-based biotechnological applications in the future. Moreover, the “clean” genetic background of the heterologous expression host allows for an unambiguous assessment of the effect of certain nif-encoded protein factors, such as AvNifM described in this work, in the maturation of AvNifH, highlighting the utility of this heterologous expression system in further advancing our understanding of the complex biosynthetic mechanism of nitrogenase.
Medical expenditure trajectory and HbA1c progression prior to and after clinical diagnosis of type 2 diabetes in a commercially insured population in the USA
Authors: Pagán Lorissa , Yang Wenya , Shao Hui , Wang Yu , Zhang Ping 
Published: November 2023

IntroductionMedical expenditures of individuals with type 2 diabetes escalate before clinical diagnosis. How increases in medical expenditures are related to glucose levels remains unclear. We examined changes in HbA1c and medical expenditures in years prior to and shortly after type 2 diabetes diagnosis.Research design and methodsUsing insurance claims and laboratory test results from a commercially insured population in the USA, we built three (2014, 2015, 2016) longitudinal cohorts with type 2 diabetes up to 10 years before and 2 years after the diagnosis (index year). We identified diabetes diagnosis using International Classification of Diseases, Ninth Revision and Tenth Revision codes and antidiabetic medication use. We ran two individual fixed regression models with annual total medical expenditures and average HbA1c values as dependent variables and number of years from diagnosis as the main independent variable and examined the risk-adjusted movement of the outcomes.ResultsOur study included 9847 individuals (83 526 person-years). Medical expenditures and HbA1c levels increased before and peaked at the diagnosis year. Medical expenditures were $8644 lower 10 years and $5781 lower 1 year before diagnosis compared with the index year. HbA1c was 12.18 mmol/mol (1.11 percentage points) and 3.49 mmol/mol (0.32 percentage points) lower, respectively. Average annual increases in medical expenditures and HbA1c values over the prediagnosis period were $318 and 0.97 mmol/mol (0.09 percentage points), respectively.ConclusionsMedical expenditures and HbA1c values followed similar trajectories before and after diabetes diagnosis. Our results can inform economic evaluations of programs and policies aimed at preventing type 2 diabetes.
Early parenting interventions to prevent internalising problems in children and adolescents: a global systematic review and network meta-analysis
Authors: Costantini Ilaria , López‐López José A , Caldwell Deborah , Campbell Amy , Hadjipanayi Veronica , Cantrell Sarah J , Thomas Tallulah , Badmann Nathan , Paul Elise , James Deborah M , Cordero Miguel , Jewell Tom , Evans Jonathan , Pearson Rebecca M 
Published: November 2023

QuestionWe compared the effectiveness of different types of parenting interventions based on an a priori taxonomy, and the impact of waitlists versus treatment as usual (TAU), in reducing child internalising problems.Study selection and analysisWe conducted a systematic review and network meta-analysis of published and unpublished randomised controlled trials (RCTs) until 1 October 2022 that investigated parenting interventions with children younger than 4 years. Exclusion criteria: studies with children born preterm, with intellectual disabilities, or families receiving support for current abuse, neglect, and substance misuse. We assessed the certainty of evidence using the Confidence in Network Meta-Analysis framework. We used random-effects network meta-analysis to estimate standardised mean differences (SMDs) with 95% credible intervals (CrIs).FindingsOf 20 520 citations identified, 59 RCTs (18 349 participants) were eligible for the network meta-analysis. Parenting interventions focusing on the dyadic relationship (SMD: −0.26, 95% CrI: −0.43 to −0.08) and those with mixed focus (−0.09, –0.17 to −0.02) were more effective in reducing internalising problems than TAU at the first time point available. All interventions were more effective than waitlist, which increased the risk of internalising problems compared with TAU (0.36, 0.19 to 0.52). All effects attenuated at later follow-ups. Most studies were rated as with ‘high risk’ or ‘some concerns’ using the Risk of Bias Assessment Tool V.2. There was no strong evidence of effect modification by theoretically informed components or modifiers.ConclusionsWe found preliminary evidence that relationship-focused and mixed parenting interventions were effective in reducing child internalising problems, and the waitlist comparator increased internalising problems with implications for waiting times between referral and support. Considering the high risk of bias of most studies included, the findings from this meta-analysis should be interpreted with caution.PROSPERO registration numberCRD42020172251.
Quantifying the potential epidemiological impact of a 2-year active case finding for tuberculosis in rural Nepal: a model-based analysis
Authors: Shrestha Sourya , Mishra Gokul , Hamal Mukesh , Dhital Raghu , Shrestha Suvesh , Shrestha Ashish , Shah Naveen Prakash , Khanal Mukti , Gurung Suman , Caws Maxine 
Published: November 2023

ObjectivesActive case finding (ACF) is an important tuberculosis (TB) intervention in high-burden settings. However, empirical evidence garnered from field data has been equivocal about the long-term community-level impact, and more data at a finer geographic scale and data-informed methods to quantify their impact are necessary.MethodsUsing village development committee (VDC)-level data on TB notification and demography between 2016 and 2017 in four southern districts of Nepal, where ACF activities were implemented as a part of the IMPACT-TB study between 2017 and 2019, we developed VDC-level transmission models of TB and ACF. Using these models and ACF yield data collected in the study, we estimated the potential epidemiological impact of IMPACT-TB ACF and compared its efficiency across VDCs in each district.ResultsCases were found in the majority of VDCs during IMPACT-TB ACF, but the number of cases detected within VDCs correlated weakly with historic case notification rates. We projected that this ACF intervention would reduce the TB incidence rate by 14% (12–16) in Chitwan, 8.6% (7.3–9.7) in Dhanusha, 8.3% (7.3–9.2) in Mahottari and 3% (2.5–3.2) in Makwanpur. Over the next 10 years, we projected that this intervention would avert 987 (746–1282), 422 (304–571), 598 (450–782) and 197 (172–240) cases in Chitwan, Dhanusha, Mahottari and Makwanpur, respectively. There was substantial variation in the efficiency of ACF across VDCs: there was up to twofold difference in the number of cases averted in the 10 years per case detected.ConclusionACF data confirm that TB is widely prevalent, including in VDCs with relatively low reporting rates. Although ACF is a highly efficient component of TB control, its impact can vary substantially at local levels and must be combined with other interventions to alter TB epidemiology significantly.