bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing TIMI, HEART, and GRACE Risk Scores to Predict Angiographic Severity of Coronary Artery Disease and 30-Day Major Adverse Cardiac Events in Emergency Department Patients with NSTEACS
Authors: Yalcin Ocak Necmiye , Yesilaras Murat , Kilicaslan Baris , Eyler Yesim , Mutlu İnan , Kutlu Murat 
Published: October 2023

AbstractBackground:Acute coronary syndromes (ACS) are hard to diagnose because their clinical presentation is broad. Current guidelines suggest early clinical risk stratification to the optimal site of care. The aim of this study was to investigate the ability of Thrombolysis in Myocardial Infarction (TIMI); History, Electrocardiogram, Age, Risk Factors, Troponin (HEART); and Global Registry of Acute Coronary Events (GRACE) risk scores to predict the development of major adverse cardiac events (MACE) and the angiographic severity of coronary artery disease (CAD) in patients diagnosed with non-ST-segment elevation acute coronary syndrome (NSTEACS) in the emergency department (ED). In addition, independent variables associated with the development of MACE were also examined.Methods:This study is a prospective, observational, single-center study. All patients over 18 years of age who were planned to be hospitalized for pre-diagnosed NSTEACS (NSTEMI + UAP) were included in the study consecutively. Patients’ demographic information and all variables necessary for calculating risk scores (TIMI, HEART, and GRACE) were recorded. Two experienced cardiologists evaluated all coronary angiograms and calculated the Gensini score.Results:The median age was 60 (IQR: 18) years, and 220 (61.6%) were male of the 357 patients included in the study. In this study, 91 MACE (52 percutaneous coronary interventions [PCI], 28 coronary artery bypass graft [CABG], three cerebrovascular disease [CVD], and eight deaths) occurred. The 30-day MACE rate was 25.5%. The low-risk group constituted 40.0%, 1.4%, and 68.0% of the population, respectively, in TIMI, HEART, and GRACE scores. Multiple logistic regression models for predicting MACE, age (P = .005), mean arterial pressure (MAP; P = .015), and High-Sensitive Troponin I (P = .004) were statistically significant.Conclusion:The ability of the GRACE, HEART, and TIMI risk scores to predict severe CAD in patients with NSTEACS is similar. In patients with NSTEACS, the HEART and GRACE risk scores can better predict the development of MACE than the TIMI risk score. When low-risk groups are evaluated according to the three risk scores, the HEART score is more reliable to exclude the diagnosis of NSTEACS.
A low-profile SIW multi-beam antenna array fed by a compact two-layer 6 × 6 BFN
Authors: Pezhman Mohammad Mahdi , Heidari Abbas Ali , Ghafoorzadeh-Yazdi Ali , Homayoon Fatemeh , Shahraki Hamed 
Published: October 2023

AbstractThis paper presents a low-profile six-beam antenna implemented by a compact two-layer 6 × 6 beamforming network (BFN) and a 6 × 2 slot antenna in substrate integrated waveguide (SIW) technology. The main components of the proposed 6 × 6 BFN are 3 × 3 multi-aperture couplers, interlayer hybrid couplers, and several phase shifters which are embedded on two microwave substrates. The proposed antenna has been designed, simulated, and fabricated for the frequency range of 28–32 GHz. The size of this antenna is 82 × 31.8 × 0.787 mm3, which can be a suitable choice for 5G applications due to its compact dimensions compared to similar works. Prototype testing shows that the proposed structure presents a stable beamforming performance both in simulation and measurement with good agreement. The antenna generates six radiation beams in directions ±9°, ±30°, and ±54° with good return losses and isolations.
Eddy‐Mean Flow Interaction With a Multiple Scale Quasi Geostrophic Model
Authors: Deremble Bruno , Uchida Takaya , Dewar William K. , Samelson Roger M. 
Published: October 2023

AbstractParameterization of mesoscale eddies in coarse resolution ocean models is necessary to include the effect of eddies on the large‐scale oceanic circulation. We propose to use a multiple‐scale Quasi‐Geostrophic (MSQG) model to capture the eddy dynamics that develop in response to a prescribed large‐scale flow. The MSQG model consists in extending the traditional quasi geostrophic (QG) dynamics to include the effects of a variable Coriolis parameter and variable background stratification. Solutions to this MSQG equation are computed numerically and compared to a full primitive equation model. The large‐scale flow field permits baroclinically unstable QG waves to grow. These instabilities saturate due to non‐linearities and a filtering method is applied to remove large‐scale structures that develop due to the upscale cascade. The resulting eddy field represents a dynamically consistent response to the prescribed background flow, and can be used to rectify the large‐scale dynamics. Comparisons between Gent‐McWilliams eddy parameterization and the present solutions show large regions of agreement, while also indicating areas where the eddies feed back onto the large scale in a manner that the Gent‐McWilliams parameterization cannot capture. Also of interest is the time variability of the eddy feedback which can be used to build stochastic eddy parameterizations.
Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease
Authors: Hao Wenyan , Zhang Hongxian , Hong Peng , Zhang Xin , Zhao Xuyang , Ma Lulin , Qiu Xiaoyan , Ping Hao , Lu Dan , Yin Yuxin 
Published: October 2023

AbstractNephrolithiasis is highly prevalent and associated with the increased risk of kidney cancer. The tumor suppressor von Hippel-Lindau (VHL) is critical for renal cancer development, however, its role in kidney stone disease has not been fully elucidated until now. Here we reported VHL expression was upregulated in renal epithelial cells upon exposure to crystal. Utilizing Vhl+/mu mouse model, depletion of VHL exacerbated kidney inflammatory injury during nephrolithiasis. Conversely, overexpression of VHL limited crystal-induced lipid peroxidation and ferroptosis in a BICD2-depdendent manner. Mechanistically, VHL interacted with the cargo adaptor BICD2 and promoted its K48-linked poly-ubiquitination, consequently resulting in the proteasomal degradation of BICD2. Through promoting STAT1 nuclear translocation, BICD2 facilitated IFNγ signaling transduction and enhanced IFNγ-mediated suppression of cystine/glutamate antiporter system Xc−, eventually increasing cell sensitivity to ferroptosis. Moreover, we found that the BRAF inhibitor impaired the association of VHL with BICD2 through triggering BICD2 phosphorylation, ultimately causing severe ferroptosis and nephrotoxicity. Collectively, our results uncover the important role of VHL/BICD2/STAT1 axis in crystal kidney injury and provide a potential therapeutic target for treatment and prevention of renal inflammation and drug-induced nephrotoxicity.
Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells
Authors: Qiu Chenyu , Shen Xin , Lu Hui , Chen Yinghua , Xu Chenxin , Zheng Peisen , Xia Yiqun , Wang Junqi , Zhang Yafei , Li Shaotang , Zou Peng , Cui Ri , Chen Jundixia 
Published: October 2023

AbstractColon cancer is a major cause of cancer-related death. Despite recent improvements in the treatment of colon cancer, new strategies to improve the overall survival of patients are urgently needed. Heat shock protein 90 (HSP90) is widely recognized as a promising target for treating various cancers, including colon cancer. However, no HSP90 inhibitor has been approved for clinical use due to limited efficacy. In this study, we evaluated the antitumor activities of HSP90 inhibitors in combination with piperlongumine in colon cancer cells. We show that combination treatment with HSP90 inhibitors and piperlongumine displayed strong synergistic interaction in colon cancer cells. These agents synergize by promoting ER stress, JNK activation, and DNA damage. This process is fueled by oxidative stress, which is caused by the accumulation of reactive oxygen species. These studies nominated piperlongumine as a promising agent for HSP90 inhibitor-based combination therapy against colon cancer.
Improved human greenspace exposure equality during 21st century urbanization
Authors: Wu Shengbiao , Chen Bin , Webster Chris , Xu Bing , Gong Peng 
Published: October 2023

AbstractGreenspace plays a crucial role in urban ecosystems and has been recognized as a key factor in promoting sustainable and healthy city development. Recent studies have revealed a growing concern about urban greenspace exposure inequality; however, the extent to which urbanization affects human exposure to greenspace and associated inequalities over time remains unclear. Here, we incorporate a Landsat-based 30-meter time-series greenspace mapping and a population-weighted exposure framework to quantify the changes in human exposure to greenspace and associated equality (rather than equity) for 1028 global cities from 2000 to 2018. Results show a substantial increase in physical greenspace coverage and an improvement in human exposure to urban greenspace, leading to a reduction in greenspace exposure inequality over the past two decades. Nevertheless, we observe a contrast in the rate of reduction in greenspace exposure inequality between cities in the Global South and North, with a faster rate of reduction in the Global South, nearly four times that of the Global North. These findings provide valuable insights into the impact of urbanization on urban nature and environmental inequality change and can help inform future city greening efforts.
MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)
Authors: García-Quintáns Nieves , Sacristán Silvia , Márquez-López Cristina , Sánchez-Ramos Cristina , Martinez-de-Benito Fernando , Siniscalco David , González-Guerra Andrés , Camafeita Emilio , Roche-Molina Marta , Lytvyn Mariya , Morera David , Guillen María I. , Sanguino María A. , Sanz-Rosa David , Martín-Pérez Daniel , Garcia Ricardo , Bernal Juan A. 
Published: October 2023

AbstractThe most prevalent genetic form of inherited arrhythmogenic cardiomyopathy (ACM) is caused by mutations in desmosomal plakophilin-2 (PKP2). By studying pathogenic deletion mutations in the desmosomal protein PKP2, here we identify a general mechanism by which PKP2 delocalization restricts actomyosin network organization and cardiac sarcomeric contraction in this untreatable disease. Computational modeling of PKP2 variants reveals that the carboxy-terminal (CT) domain is required for N-terminal domain stabilization, which determines PKP2 cortical localization and function. In mutant PKP2 cells the expression of the interacting protein MYH10 rescues actomyosin disorganization. Conversely, dominant-negative MYH10 mutant expression mimics the pathogenic CT–deletion PKP2 mutant causing actin network abnormalities and right ventricle systolic dysfunction. A chemical activator of non-muscle myosins, 4-hydroxyacetophenone (4-HAP), also restores normal contractility. Our findings demonstrate that activation of MYH10 corrects the deleterious effect of PKP2 mutant over systolic cardiac contraction, with potential implications for ACM therapy.
Globally distributed Myxococcota with photosynthesis gene clusters illuminate the origin and evolution of a potentially chimeric lifestyle
Authors: Li Liuyang , Huang Danyue , Hu Yaoxun , Rudling Nicola M. , Canniffe Daniel P. , Wang Fengping , Wang Yinzhao 
Published: October 2023

AbstractPhotosynthesis is a fundamental biogeochemical process, thought to be restricted to a few bacterial and eukaryotic phyla. However, understanding the origin and evolution of phototrophic organisms can be impeded and biased by the difficulties of cultivation. Here, we analyzed metagenomic datasets and found potential photosynthetic abilities encoded in the genomes of uncultivated bacteria within the phylum Myxococcota. A putative photosynthesis gene cluster encoding a type-II reaction center appears in at least six Myxococcota families from three classes, suggesting vertical inheritance of these genes from an early common ancestor, with multiple independent losses in other lineages. Analysis of metatranscriptomic datasets indicate that the putative myxococcotal photosynthesis genes are actively expressed in various natural environments. Furthermore, heterologous expression of myxococcotal pigment biosynthesis genes in a purple bacterium supports that the genes can drive photosynthetic processes. Given that predatory abilities are thought to be widespread across Myxococcota, our results suggest the intriguing possibility of a chimeric lifestyle (combining predatory and photosynthetic abilities) in members of this phylum.
Sub-THz wireless transmission based on graphene-integrated optoelectronic mixer
Authors: Montanaro Alberto , Piccinini Giulia , Mišeikis Vaidotas , Sorianello Vito , Giambra Marco A. , Soresi Stefano , Giorgi Luca , D’Errico Antonio , Watanabe K. , Taniguchi T. , Pezzini Sergio , Coletti Camilla , Romagnoli Marco 
Published: October 2023

AbstractOptoelectronics is a valuable solution to scale up wireless links frequency to sub-THz in the next generation antenna systems and networks. Here, we propose a low-power consumption, small footprint building block for 6 G and 5 G new radio wireless transmission allowing broadband capacity (e.g., 10–100 Gb/s per link and beyond). We demonstrate a wireless datalink based on graphene, reaching setup limited sub-THz carrier frequency and multi-Gbit/s data rate. Our device consists of a graphene-based integrated optoelectronic mixer capable of mixing an optically generated reference oscillator approaching 100 GHz, with a baseband electrical signal. We report >96 GHz optoelectronic bandwidth and −44 dB upconversion efficiency with a footprint significantly smaller than those of state-of-the-art photonic transmitters (i.e., <0.1 mm2). These results are enabled by an integrated-photonic technology based on wafer-scale high-mobility graphene and pave the way towards the development of optoelectronics-based arrayed-antennas for millimeter-wave technology.
USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Authors: Qin Kewei , Yu Shuhan , Liu Yang , Guo Rongtian , Guo Shiya , Fei Junjie , Wang Yuemeng , Jia Kaiyuan , Xu Zhiqiang , Chen Hu , Li Fengtian , Niu Mengmeng , Dai Mu-Shui , Dai Lunzhi , Cao Yang , Zhang Yujun , Xiao Zhi-Xiong Jim , Yi Yong 
Published: October 2023

AbstractTumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain unclear. Here we show that Snail1, a key factor in the regulation of epithelial-to-mesenchymal transition, plays a pivotal role in cellular surveillance response upon ribotoxic stress. Mechanistically, ribotoxic stress activates the JNK-USP36 signaling to stabilize Snail1 in the nucleolus, which facilitates ribosome biogenesis and tumor cell survival. Furthermore, we show that HHT activates the JNK-USP36-Snail1 axis in solid tumor cells, but not in leukemia cells, resulting in solid tumor cell resistance to HHT. Importantly, a combination of HHT with the inhibition of the JNK-USP36-Snail1 axis synergistically inhibits solid tumor growth. Together, this study provides a rationale for targeting the JNK-USP36-Snail1 axis in ribosome inhibition-based solid tumor therapy.
Efficacy of immune checkpoint inhibitor therapy for advanced urothelial carcinoma in real-life clinical practice: results of a multicentric, retrospective study
Authors: Váradi Melinda , Horváth Orsolya , Módos Orsolya , Fazekas Tamás , Grunewald Camilla M. , Niegisch Günter , Krafft Ulrich , Grünwald Viktor , Hadaschik Boris , Olah Csilla , Maráz Anikó , Furka Andrea , Szűcs Miklós , Nyirády Péter , Szarvas Tibor 
Published: October 2023

AbstractClinical trials revealed significant antitumor activity for immune checkpoint inhibitors (ICI) in metastatic urothelial carcinoma (mUC). Due to their strict eligibility criteria, clinical trials include selected patient cohorts, and thus do not necessarily represent real-world population outcomes. In this multicentric, retrospective study, we investigated real-world data to assess the effectiveness of pembrolizumab and atezolizumab and to evaluate the prognostic value of routinely available clinicopathological and laboratory parameters. Clinical and follow-up data from mUC patients who received ICIs (01/2017-12/2021) were evaluated. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and duration of response (DOR) were used as endpoints. Patients’ (n = 210, n = 76 atezolizumab and 134 pembrolizumab) median OS and PFS were 13.6 and 5.9 months, respectively. Impaired ECOG-PS, the presence of visceral, liver or bone metastases, and hemoglobin levels were independently associated with poor OS and DCR. Furthermore, Bellmunt risk factors and the enhanced Bellmunt-CRP score were shown to be prognostic for OS, PFS and DCR. In conclusion, ICIs are effective treatments for a broad range of mUC patients. Our results confirmed the prognostic value of numerous risk factors and showed that Bellmunt risk scores can further be improved when adding CRP to the model.
A robust automated machine-learning method for the identification of star clusters in the central region of the Small Magellanic Cloud
Authors: Strantzalis A. , Lazarou D. , Hatzidimitriou D. , Zezas A. , Antoniou V. , Reskos N. 
Published: October 2023

Aims. We developed a cluster-detection method based on the code DBSCAN to identify star clusters in the central region of the Small Magellanic Cloud (SMC).
Methods. Two approaches were used to determine the values of the free parameters of DBSCAN. They agree well with each other and can be used in the fields that are studied without any a priori knowledge of clustering, characteristic scales, or background density. We validated the success of the DBSCAN cluster-detection method on recent cluster catalogues after introducing a cluster-classification scheme based on three diagnostics that relie on colour-magnitude diagrams and growth curves. We used data from the Magellan Telescope at the Las Campanas Observatory in Chile and from Gaia Data Release 3.
Results. As a byproduct of the validation process, we revisited objects that were classified as clusters in recent compilations. We found that 40% fail all diagnostics and most probably are not clusters. DBSCAN was very successful in recovering actual clusters with high precision and recall.
Shock imprints on the radio mini halo in RBS 797
Authors: Bonafede A. , Gitti M. , La Bella N. , Biava N. , Ubertosi F. , Brunetti G. , Lusetti G. , Brienza M. , Riseley C. J. , Stuardi C. , Botteon A. , Ignesti A. , Röttgering H. , van Weeren R. J. 
Published: October 2023

Aims. In this work, we analysed new LOw Frequency ARray observations of the mini halo in the cluster RBS 797, together with archival Very Large Array observations and the recent Chandra results. This cluster is known to host a powerful active galactic nucleus (AGN) at its centre, with two pairs of jets propagating in orthogonal directions. Recent X-ray observations have detected three pairs of shock fronts within 125 kpc from the cluster centre, connected with the activity of the central AGN. Our aim is to investigate the connection between the mini halo emission and the activity of the central source.
Methods. We have used different methods to separate the emission of the central source from the diffuse mini halo emission, and we have derived the radial spectral index trend of the mini halo.
Results. We find that the diffuse radio emission is elongated in different directions at 144 MHz (east-west) with respect to 1.4 GHz (north-south), tracing the orientation of the two pairs of jets. The mini halo emission is characterised by an average spectral index α = −1.02 ± 0.05. The spectral index profile of the mini halo shows a gradual flattening from the centre to the periphery. Such a trend is unique among the mini halos studied to date, and resembles the spectral index trend typical of particles re-accelerated by shocks. However, the estimated contribution to the radio brightness profile coming from shock re-acceleration is found to be insufficient to account for the radial brightness profile of the mini halo.
Conclusions. We propose three scenarios that could explain the observed trend: (i) the AGN-driven shocks are propagating onto an already existing mini halo, re-energising the electrons and leaving clear imprints in the mini halo spectral properties. We estimate that the polarisation induced by the shocks could be detected at 6 GHz and above; (ii) we could be witnessing turbulent re-acceleration in a high magnetic field cluster; and (iii) the mini halo could have a hadronic origin, in which the particles are injected by the central AGN and the diffusion coefficient depends of the cosmic ray proton momentum. Future observations in polarisation would be fundamental to understand the role of shocks and of the magnetic field.
Performance en course à pied et forme des stades
Authors: Aftalion Amandine 
Published: October 2023

La course à pied se décline en plusieurs distances que l’on pourra admirer lors des Jeux Olympiques de Paris, avec à la clé de possibles nouveaux records du monde. Et si les stratégies des champions pouvaient devenir accessibles à tous les coureurs ?
Grâce à un modèle qui repose sur un problème de contrôle de la force de propulsion (et donc de la vitesse) afin d’optimiser la dépense énergétique et le temps final, nous déterminons comment les coureurs doivent optimiser au mieux leur rythme afin de réaliser la meilleure performance et proposons d’améliorer la forme historique des stades.
11 Revisionen eines Oberarm-Cephalica-Basilica-Shunts in 22 Jahren
Authors: Krönung Gerhard 
Published: October 2023

ZUSAMMENFASSUNGEine Kette unsicherer Revisionsindikationen, wiederholt überraschende Verläufe, kontinuierliche shuntchirurgische Zuwendung und ein hartnäckiger Patient sind trotz Komplikationen und zunehmender Substratproblematik (Venenwandverkalkung) die Zutaten für die folgende unerwartete Erfolgsgeschichte.