bluuebunny/crossref_metadata_2025_split huggingface dataset:
UBE2C serves as a prognosis biomarker of uterine corpus endometrial carcinoma via promoting tumor migration and invasion
Authors: Ma Sijia , Chen Qian , Li Xu , Fu Jing , Zhao Le 
Published: October 2023

AbstractThe biological functions of ubiquitin-conjugating enzymes E2 (UBE2) family members in uterine corpus endometrial carcinoma (UCEC) remains unclear. Our study aimed to systematically analyze the expression patterns, prognostic value, biological functions and molecular regulatory mechanisms of UBE2 family in UCEC. Among nine screened UBE2 family members associated with UCEC, UBE2C was the most significantly overexpressed gene with poor prognosis. High expression levels of UBE2C in UCEC was correlated with stages, histological subtypes, patient’s menopause status and TP53 mutation. Three molecules (CDC20, PTTG1 and AURKA), were identified as the key co-expression proteins of UBE2C. The generic alterations (mutation, amplification) and DNA hypomethylation might contribute to UBE2C’s high expression in UCEC. Furthermore, in vitro experiments showed that the interference of UBE2C inhibited the migration and invasion of endometrial cancer cells, while partially impact cell proliferation and didn’t impact the expression of epithelial-mesenchymal transition (EMT) markers. Using comprehensive bioinformatics analysis and in vitro experiments, our study provided a novel insight into the oncogenic role of UBE2 family, specifically UBE2C in UCEC. UBE2C might serve as an effective biomarker to predict poor prognosis and a potential therapeutic target in clinical practice.
GM1a ganglioside-binding domain peptide inhibits host adhesion and inflammatory response of enterotoxigenic Escherichia coli heat-labile enterotoxin-B in HCT-8 cells
Authors: Park Jun-Young , Abekura Fukushi , Cho Seung-Hak 
Published: October 2023

AbstractEnterotoxigenic Escherichia coli (ETEC) is a major cause of illness and death but has no effective therapy. The heat-labile enterotoxin LT is a significant virulence factor produced by ETEC. The heat-labile enterotoxin-B (LT-B) subunit may enter host cells by binding to monosialotetrahexosylganglioside-a (GM1a), a monosialoganglioside found on the plasma membrane surface of animal epithelial cells. This research was conducted to develop conformationally comparable peptides to the carbohydrate epitope of GM1a for the treatment of ETEC. We used the LT-B subunit to select LT-B-binding peptides that structurally resemble GM1a. The ganglioside microarray and docking simulations were used to identify three GM1a ganglioside-binding domain (GBD) peptides based on LT-B recognition. Peptides had an inhibiting effect on the binding of LT-B to GM1a. The binding capacity, functional inhibitory activity, and in vitro effects of the GBD peptides were evaluated using HCT-8 cells, a human intestinal epithelial cell line, to evaluate the feasibility of deploying GBD peptides to combat bacterial infections. KILSYTESMAGKREMVIIT was the most efficient peptide in inhibiting cellular absorption of LT-B in cells. Our findings offer compelling evidence that GM1a GBD-like peptides might act as new therapeutics to inhibit LT-B binding to epithelial cells and avoid the subsequent physiological consequences of LT.
The impact of a skipped-generation family structure on early child development in Khon Kaen Province: a prospective cohort study
Authors: Photichai Piyanan , Luvira Varisara 
Published: October 2023

AbstractParenting in early childhood is related to child development. This study aimed to investigate the impact of a skipped-generation family structure on early child development. This prospective cohort study collected data on children aged 6 to 18 months from 132 non-skipped-generation families and 115 skipped-generation families from primary care units in Khon Kaen province for 1 year. The data were collected using a structured questionnaire administered through face-to-face interviews, as well as the Denver II instrument for assessing child development. Using multivariate logistic regression, the impact of a skipped-generation family structure on infant development was analysed, and adjusted relative risks (aRRs) are presented. We found that 19.83% (49/247) of the children had suspected delayed development in all domains. Most of these children resided in skipped-generation families, accounting for 27.82% of the sample (32/115). After adjusting for other factors, it was found that male children from skipped-generation families had a higher risk of suspected delayed language development (aRR = 14.56, 95% CI = 1.34 to 158.34, p = 0.028). In conclusion, the parental practices of skipped-generation families are suspected of causing delayed language development in boys. Models of early childhood development should be established for skipped-generation families.
Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length
Authors: Hu Jingyi , Lu Jiawen , Lu Qiuhan , Weng Weipin , Guan Zixuan , Wang Zhenqian 
Published: October 2023

AbstractObservational studies suggest certain sleep traits are associated with telomere length, but the causal nature of these associations is unclear. The study aimed to determine the causal associations between 11 sleep-related traits and leukocyte telomere length (LTL) through two-sample Mendelian randomization and colocalization analyses using the summary statistics from large-scale genome-wide association studies. Univariable Mendelian randomization indicates that genetically determined short sleep is associated with decreased LTL, while morning chronotype is associated with increased LTL. Multivariable Mendelian randomization further supports the findings and colocalization analysis identifies shared common genetic variants for these two associations. No genetic evidence is observed for associations between other sleep-related traits and LTL. Sensitivity MR methods, reverse MR and re-running MR after removing potential pleiotropic genetic variants enhance the robustness of the results. These findings indicate that prioritizing morning chronotype and avoiding short sleep is beneficial for attenuating telomere attrition. Consequently, addressing sleep duration and chronotype could serve as practical intervention strategies.
Corporate motivations and co-benefit valuation in private climate finance investments through voluntary carbon markets
Authors: Lou Jiehong , Hultman Nathan , Patwardhan Anand , Mintzer Irving 
Published: October 2023

AbstractCompanies can prioritize diverse types of sustainable investment finance to reflect their concerns about climate change and carbon emissions. One such investment avenue is voluntary carbon offset (VCO) projects, in which companies invest to offset their carbon footprint. However, despite growing research into what and how these companies are doing in VCO markets, much remains to be learned about the motivations for such investments. In this paper, we utilized two datasets with a natural linkage to conduct a mixed-method analysis for a group of 186 companies globally with 534 carbon offset projects in 2017. This allowed us to assess motivations that drive companies to invest in the offset projects, and how different motivations map on to specific purchase decisions which then channel into larger financial flows. We identified three corporate motivations for carbon offset investment and found that companies using carbon offsets to achieve carbon neutrality has been coupled with some companies highlighting the importance of using offsets to contribute to “company values” and “market competitiveness.” Our study uncovered two contrasting trends in offset investment. Companies driven by values and market competitiveness demonstrated a willingness to invest in high-cost projects that provide significant local co-benefits. On the other hand, companies motivated by carbon management and efficiency showed a preference for lower-cost projects, particularly those related to renewable energy.
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition
Authors: Kavanaugh Logan G. , Mahoney Andrew R. , Dey Debayan , Wuest William M. , Conn Graeme L. 
Published: October 2023

AbstractThe Resistance-Nodulation-Division (RND) efflux pump superfamily is pervasive among Gram-negative pathogens and contributes extensively to clinical antibiotic resistance. The opportunistic pathogen Pseudomonas aeruginosa contains 12 RND-type efflux systems, with four contributing to resistance including MexXY-OprM which is uniquely able to export aminoglycosides. At the site of initial substrate recognition, small molecule probes of the inner membrane transporter (e.g., MexY) have potential as important functional tools to understand substrate selectivity and a foundation for developing adjuvant efflux pump inhibitors (EPIs). Here, we optimized the scaffold of berberine, a known but weak MexY EPI, using an in-silico high-throughput screen to identify di-berberine conjugates with enhanced synergistic action with aminoglycosides. Further, docking and molecular dynamics simulations of di-berberine conjugates reveal unique contact residues and thus sensitivities of MexY from distinct P. aeruginosa strains. This work thereby reveals di-berberine conjugates to be useful probes of MexY transporter function and potential leads for EPI development.
Carbon-supported T-Nb2O5 nanospheres and MoS2 composites with a mosaic structure for insertion–conversion anode materials
Authors: Li Shaohao , Pan Caifeng , Zhao Zhaohui , Yang Wei , Zou Hanbo , Chen Shengzhou 
Published: October 2023

In this paper, we load carbon into MoS2 with T-Nb2O5 nanospheres using hydrothermal synthesis, add polydopamine carbon and heat treat. This accelerates charge transfer and reduces volume expansion for excellent T-Nb2O5@MoS2@C electrode performance.
Emerging the real‐time performance for the single axis slave controller in the decentralised network
Authors: Bui The Tri , Ngo Ha Quang Thinh 
Published: October 2023

AbstractIn the era of the fourth industrial revolution, many certain technologies such as Internet of Things (IoT) or Internet of Service (IoS) have been implemented for the improvement of current system. However, most of them did not ensure the real‐time performance which is inevitable for modern motion systems. The implementation of Ethernet‐based protocol, rapid data exchange and synchronised transmission are proper for the novelties of slave controller. An integration of the decentralised network into the motion control system is introduced firstly. To demonstrate the conceptual design, some descriptions of motivations and related definitions are explained. Then, the structure of hardware components and internal connections are mentioned. Later, the software architecture including the data exchange and flowchart of motion program, is described in detail. To verify the feasibility and effectiveness of the proposed approach, some technical analysis of timing synchronisation and tracking deviation between our method and the others are carried out. In addition, several practical validations are conducted in the same conditions. The contributions of the authors are (i) to firstly present the concept of controller design using the real‐time technology, (ii) to illuminate both hardware design and software design of the proposed approach and (iii) to analyse the superior performance in delay time between our method and the others as well as validate the real‐world results to prove the effectiveness and feasibility. From the authors’ achievement, it is observed that these results can be broadly purposeful to the sustainable development of Industry 4.0.
The birth and early evolution of a low-mass protostar
Authors: Ahmad A. , González M. , Hennebelle P. , Commerçon B. 
Published: October 2023

Context. Understanding the collapse of dense molecular cloud cores to stellar densities and the subsequent evolution of the protostar is of importance to model the feedback effects such an object has on its surrounding environment, as well as describing the conditions with which it enters the stellar evolutionary track. This process is fundamentally multi-scale, both in density and in spatial extent, and requires the inclusion of complex physical processes such as self-gravity, turbulence, radiative transfer, and magnetic fields. As such, it necessitates the use of robust numerical simulations.
Aims. We aim to model the birth and early evolution of a low-mass protostar. We also seek to describe the interior structure of the protostar and the radiative behavior of its accretion shock front.
Methods. We carried out a high resolution numerical simulation of the collapse of a gravitationally unstable 1 M⊙ dense molecular cloud core to stellar densities using 3D radiation hydrodynamics under the gray flux-limited diffusion approximation. We followed the initial isothermal phase, the first adiabatic contraction, the second gravitational collapse triggered by the dissociation of H2 molecules, and ≈247 days of the subsequent main accretion phase.
Results. We find that the subcritical radiative behavior of the protostar’s shock front causes it to swell as it accretes matter. We also find that the protostar is turbulent from the moment of its inception despite its radiative stability. This turbulence causes significant entropy mixing inside the protostar, which regulates the swelling. Furthermore, we find that the protostar is not fully ionized at birth, but the relative amount of ionized material within it increases as it accretes matter from its surroundings. Finally, we report in the appendix the results of the first 3D calculations involving a frequency-dependent treatment of radiative transfer, which has not produced any major differences with its gray counterpart.
Correlations between laboratory line lists for FeH, CrH, and NiH and M-star spectra collected with ESPaDOnS and SPIRou
Authors: Crozet P. , Morin J. , Ross A. J. , Bellotti S. , Donati J.-F. , Fouqué P. , Moutou C. , Petit P. , Carmona A. , Kóspál A. , Adam A. G. , Tokaryk D. W. 
Published: October 2023

Context. Molecular bands of metal oxides and hydrides dominate the optical and near-infrared spectra of M dwarfs. High-resolution spectra of these bands have immense potential for determining many properties of these stars, such as effective temperature, surface gravity, elemental abundances, radial velocity, or surface magnetic fields. Techniques are being developed to do this but remain limited by the current availability and accuracy of molecular data and spectral line lists.
Aims. This paper reports metal monohydride line lists selected from near-infrared and visible laboratory data to show that specific bands in several electronic transitions can be used to identify CrH, NiH, and FeH in M stars and to determine radial velocities from Doppler shifts. The possibility of measuring magnetic fields is also investigated for FeH and CrH.
Methods. We used systematic cross-correlation analysis between unpolarised spectra from a selection of M stars and state-specific laboratory line lists. These lists were generated from a combination of existing data and new laboratory laser-excitation spectra recorded at Doppler-limited resolution, in zero-field conditions or in magnetic fields up to 0.6 tesla.
Results. We show that transitions at visible wavelengths in FeH and NiH, usually neglected in the analysis of the spectra of M-type stars, do in fact contribute to the spectra, and we demonstrate the influence of magnetic sensitivity on selected transitions in CrH and FeH.
Conclusions. Although the new line lists focus on transitions recorded at temperatures significantly lower than those of stellar objects, they remain pertinent because they cover some band-head regions of high spectral density. FeH bands can provide a useful supplement to atomic lines for the analysis of high-resolution optical and near-infrared spectra of M dwarfs. We demonstrate the influence of a magnetic field on CrH signatures around 862 nm.
Weight Gain and Cardiopulmonary Bypass
Authors: Vertrees Roger A. , Stark Maryann , Auvil Jackson , Rohrer Charlene , Rousou John H. , Engelman Richard M. 
Published: October 2023

Seventy-two consecutive patients undergoing coronary revascularization were divided initially into three groups consisting of those with perfusion time less than or equal to 90 minutes (Group I), those with perfusion time between 90 and 150 minutes (Group II), and those with perfusion time 150 minutes or longer (Group III). The patients having the longest perfusion displayed, as anticipated, the highest weight gain of 4.4 ± 0.6 Kg following cardiopulmonary bypass in contrast to 2.6 ± 0.3 Kg in Group II and 2.1 ± 0.3 Kg in Group I (p < 0.05). This corresponds to a linear progression with increasing weight gain proportional to increasing perfusion time (0.02-0.03 Kg/min of bypass).
These same 72 patients were then divided into two groups: Group A having weight gain less than 2.0 Kg and Group B with weight gain of 2.0 or more Kg. Group B showed a significant reduction of 39% in the serum protein level and 28% in serum albumin as compared to the control level. This is significantly different from the 28% reduction in total serum protein and 17% reduction in serum albumin as was noted in Group A, having the shorter bypass interval (p < 0.05). Thus, while the duration of perfusion is primarily responsible for fluid accumulation and weight gain, the low serum protein may serve to accentuate edema formation. Hemodilution and nonpulsatile flow are factors promoting tissue edema during cardiopulmonary bypass.
Research on highly dynamic 3D measurement method based on RGB color fringe projection
Authors: Fu Ling , Gao Dingshan 
Published: October 2023

Metal parts with highly dynamic areas often appear in industrial production measurements. However, if the traditional fringe projection technique is used to project fringe onto the surface of these metal parts, the light energy will be excessively concentrated and the image will be saturated, resulting thus in the loss of fringe information. To effectively address the high reflectivity problem of the object under test in fringe projection, background normalized Fourier transform contouring was combined with adaptive fringe projection in this work and a new method for performing highly dynamic 3D measurements was proposed. To reduce the number of the acquired images by the camera, a monochromatic fringe of different frequencies was put into the RGB channel to make color composite fringe, and then a color camera was used to acquire the deformed color composite fringe map. The images acquired by the color camera were then separated into three channels to obtain three deformed stripe maps. The crosstalk was also removed from these three images, and the 3D shape of the object was reconstructed by carrying out Fourier transform contouring with background normalization. From our experiments, it was demonstrated that the root mean square error of the proposed method can reach 0.191 mm, whereas, unlike the traditional methods, the developed method requires four images.
Abortion in the First Trimester. Guideline of the DGGG (S2k-Level, AWMF Registry No. 015-094, December 2022) – Part 2 with Recommendations for Surgical Termination of
Pregnancy and Follow-up Care After Termination of Pregnancy
Authors: David Matthias , Achtenhagen Anne , Bamberg Christian , Bormann Cornelia , Felderhoff-Müser Ursula , Groth Sylvia , Hänel Kristina , König Klaus , Korell Matthias , Michl Susanne , Redler Silke , Schleußner Ekkehard , Seyler Helga , Wallwiener Markus , Wallwiener Stephanie 
Published: October 2023

Abstract
Purpose The aim was to develop evidence-based recommendations where possible. The guideline presents the medical principles and scientific evidence for indications, counselling of
affected persons, performing terminations, the choice of method, and the care and monitoring of a terminated pregnancy up until week 12 + 0 of gestation p. c.
Methods In accordance with the requirements for an S2k-guideline, the contents of the guideline were drafted following a systematic search of the literature by a representative
interdisciplinary group of experts. Guideline authors held several formal meetings under the auspices of the German Society for Gynaecology and Obstetrics (DGGG) during which the contents of
the guideline were finalised and agreed upon.
Recommendations The guideline provides recommendations on the surgical termination of pregnancy and follow-up care after termination of pregnancy.
Kontrastverstärkte Sonografie (CEUS) zur Diagnostik fokaler Leberläsionen
Authors: Kallenbach Michael , Qvartskhava Natalia , Weigel Christian , Dörffel Yvonne , Berger Jens , Kunze Georg , Luedde Tom 
Published: October 2023

ZusammenfassungAufgrund des Trends zum vermehrten Einsatz der Bildgebung und der steigenden Awareness bei Risikopatienten werden gastroenterologisch und hepatologisch tätige Ärztinnen und Ärzte häufiger mit Patienten mit unklaren Leberläsionen konfrontiert. In der Differenzierung dieser Raumforderungen hielten CT und MRT im klinischen Alltag zunehmend Einzug in primäre Diagnostikschritte. Die kontrastverstärkte Sonografie stellt demgegenüber ein sehr effektives und kosteneffizientes Verfahren zur Beurteilung fokaler Leberläsionen dar. Der Erfolg der Methode beruht nicht nur auf der Darstellung der Mikrovaskularisation in Echtzeit. Wird die Sonografie vom Behandelnden selbst durchgeführt, kann dieser die genaue Kenntnis der Anamnese und der klinischen Befunde nutzen, um den Untersuchungsablauf gezielt anzupassen und den sonographischen Befund mit größerer Treffsicherheit zu interpretieren („klinische Sonografie“). Gleichzeitig versetzt die Methode den Behandelnden in die Lage, Diagnostik und Therapieentscheidung in den eigenen Händen zusammenzuführen. Exzellente Ergebnisse erzielt die kontrastverstärkte Sonografie – wie alle anderen bildgebenden Verfahren auch – nur bei ausreichender Qualifikation des Untersuchenden.Dieser Beitrag stellt die sonographischen Charakteristika der häufigsten Leberläsionen übersichtlich dar und zeigt deren Kontrastierungsmuster anschaulich anhand von Videos (via QR-Code abrufbar). Der Artikel verdeutlicht, dass die KM-Sonografie aus hepatologischer Sicht in Zukunft einen noch größeren Stellenwert haben könnte und aus Sicht der Autoren haben sollte.
Exercise and Atrial Fibrillation: The Dose Makes the Poison? A
Narrative Review
Authors: Zacher Jonas , Filipovic Karlo , Predel Georg , Schmidt Thomas 
Published: October 2023

Abstract“All things are poison, and nothing is without poison; the dosage alone
makes it so a thing is not a poison” (Paracelsus, ~ 1538 AD).
This well-known quote seems to aptly summarize the current understanding of the
interaction between exercise and atrial fibrillation (AF). A host of data
strongly suggests that regular exercise has a protective effect against
developing AF. A small but well-conducted group of trials also demonstrates
beneficial effects of exercise in the treatment of AF. Recently, however,
potentially detrimental effects of large volumes of high-intensity exercise on
the probability of developing AF have moved into the sports-cardiological focus.
This effect is well documented for elite athletes; data regarding the general
population is less clear. This review presents the current data regarding the
protective, therapeutic and potentially risk-enhancing effects of exercise
regarding AF. The authors demonstrate that the benefits are clear and strongly
outweigh the potential disadvantages.