bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral manifestations of amyloidosis and the diagnostic applicability of oral tissue biopsy
Authors: Tavares Thalita Soares , da Costa Adriana Aparecida Silva , Araújo Anna Luíza Damaceno , de Souza Lucas Lacerda , Pascoaloti Maria Inês Mantuani , Bernardes Vanessa Fátima , Aguiar Maria Cássia Ferreira , Vargas Pablo Agustin , Fonseca Felipe Paiva , Pontes Hélder Antônio Rebelo , Lopes Marcio Ajudarte , Santos‐Silva Alan Roger , da Silva Tarcília Aparecida , Caldeira Patrícia Carlos 
Published: December 2023

AbstractBackgroundAmyloidosis exhibits a variable spectrum of systemic signs and oral manifestations that can be difficult to diagnose. This study aimed to characterize the clinical, demographic, and microscopic features of amyloidosis in the oral cavity.MethodsThis collaborative study involved three Brazilian oral pathology centers and described cases with a confirmed diagnosis of amyloidosis on available oral tissue biopsies. Clinical data were obtained from medical records. H&E, Congo‐red, and immunohistochemically stained slides were analyzed.ResultsTwenty‐six oral biopsies from 23 individuals (65.2% males; mean age: 59.6 years) were included. Oral involvement was the first sign of the disease in 67.0% of cases. Two patients had no clinical manifestation in the oral mucosa, although the histological analysis confirmed amyloid deposition. Amyloid deposits were distributed in perivascular (88.0%), periacinar and periductal (80.0%), perineurial (80.0%), endoneurial (33.3%), perimuscular (88.2%), intramuscular (94.1%), and subepithelial (35.3%) sites as well as around fat cells (100.0%). Mild/moderate inflammation was found in 65.4% of cases and 23.1% had giant cells.ConclusionsAmyloid deposits were consistently found in oral tissues, exhibiting distinct deposition patterns. Oral biopsy is less invasive than internal organ biopsy and enables the reliable identification of amyloid deposits even in the absence of oral manifestations. These findings corroborate the relevance of oral biopsy for the diagnosis of amyloidosis.
Presence of esophageal contractility after achalasia treatment is associated with improved esophageal emptying
Authors: Vespa Edoardo , Farina Domenico A. , Pandolfino John E. , Kahrilas Peter J. , Koop Andree H. , Carlson Dustin A. 
Published: December 2023

AbstractBackground and AimsSome achalasia patients exhibit esophageal contractile activity on follow‐up after treatment, yet its importance remains unclear. We aimed to identify factors associated with presence of contractility after treatment and to assess its impact on timed barium esophagram (TBE) and clinical outcomes.MethodsPatients with type I or II achalasia on baseline high‐resolution manometry (HRM) who completed HRM, TBE, and functional lumen imaging probe (FLIP) after treatment were retrospectively identified. Contractility was defined on post‐treatment HRM as presence of at least 1 supine swallow with DCI ≥100 mmHg s cm.Key ResultsOne hundred twenty‐two patients were included (mean age 48 ± 17 years, 50% female). At follow‐up evaluation after treatment (54% peroral endoscopic myotomy, 24% pneumatic dilation, 22% laparoscopic Heller myotomy), 61 (50%) patients had contractility on HRM. Patients with contractility (compared to those without) more frequently had type II achalasia (84% vs 57%, p = 0.001) and a post‐treatment normal EGJ opening classification on FLIP (69% vs 49%; p < 0.001). In the subgroup of patients with post‐treatment integrated relaxation pressure <15 mmHg and normal EGJ opening on FLIP (n = 53), those with contractility had a lower median column height on TBE at 1 min (4 vs 7 cm, p = 0.002) and 5 min (0 vs 5 cm, p = 0.001). In patients with “abnormal” EGJ metrics, patients with contractility showed lower symptom scores (median Eckardt score 2 vs 3, p = 0.03).Conclusions & InferencesOccurring more frequently in type II achalasia, and if adequate EGJ opening is achieved after treatment, esophageal contractility may contribute to improved esophageal emptying and improved symptoms in non‐spastic achalasia. Preservation of esophageal body muscle could improve outcomes in these patients.
The misapplication dilemma
Authors: Webber Daniel 
Published: December 2023

AbstractWhen policymakers craft rules for use by the general public, they must take into account the ways in which their rules are likely to be misapplied. Should contractualists and rule consequentialists do the same when they search for rules whose general acceptance would be non‐rejectable or ideal? I argue that these theorists face a dilemma. If they ignore the possibility of misapplication, they end up with an unrealistic view that rejects rules designed to protect us from others’ mistakes. On the other hand, if they take misapplication into account, they end up rejecting rules that appeal to what really matters morally in favor of easier‐to‐apply proxies for these rules. This leaves them unable to say why certain wrong acts are wrong, which in turn may lead them to mistaken verdicts about moral worth and wronging. I show how this misapplication dilemma applies to standard contractualist and rule consequentialist theories, but also suggest how it might generalize to other two‐level theories, including those designed to avoid the ideal world objection.
Prenatal ultrasound detection of collodion membrane in association with an autosomal recessive congenital ichthyosis due to transglutaminase 1 deficiency
Authors: Cordisco Adalgisa , Lozza Virginia , Di Marco Chiara , Cecconi Antonella , Pisaneschi Elisa , Berti Samantha Federica , Adamo Laura , Lori Ilaria , Belli Gilda , Gambi Beatrice 
Published: December 2023

AbstractWe describe a case of collodion baby diagnosed prenatally by ultrasound. Classic signs (ectropion, flattened nose, and eclabion) were detected on routine ultrasound at 21 weeks of gestation. At birth, the presence of collodion membrane was confirmed and subsequently, the diagnosis of an autosomal recessive congenital ichthyosis due to compound heterozygosity of the TGM1 gene was made.
GABA in plants: developmental and stress resilience perspective
Authors: Gahlowt Priya , Tripathi Durgesh Kumar , Singh Surendra Pratap , Gupta Ravi , Singh Vijay Pratap 
Published: December 2023

AbstractGamma‐aminobutyric acid (GABA), a ubiquitously present non‐proteinogenic amino acid, has recently emerged as a key regulator of growth and development in plants during normal as well as challenging environmental conditions. GABA biosynthesis has been reported at multiple stages of plant development, particularly during vegetative and reproductive stages and in response to stress conditions. Accumulating evidence has highlighted the crucial roles of various cell cycle regulators such as type‐D cyclins and CDK;A1, transcription factors such as E2Fa, as well as Ca2+/Calmodulin proteins in GABA biosynthesis in plants. GABA is known to improve stress tolerance by improving photosynthetic activity, C/N metabolism, stomatal conductance, and stress‐induced reactive oxygen species (ROS) detoxification. Here, we have reviewed recent studies that have explored the novel roles of GABA in plants with a focus on plant development and stress resilience.
Bioinformatic and Expression Analyses of the Wall‐Associated Kinase Genes Under High‐Temperature Stress in Sorghum
Authors: Whyte Terik Djabeng , Sipahi Hulya 
Published: December 2023

AbstractSorghum (Sorghum bicolor L. Moench) is the world's fifth most‐produced cereal. The wall‐associated kinases (WAKs) gene family plays a crucial regulatory role in various aspects of plant biology, including the response to environmental stress and pathogens. Therefore, we aimed to characterize the members of the WAK gene family in sorghum using bioinformatics tools and to determine their functional roles in heat stress by detecting transcript levels using RT‐qPCR. A total of 98 SbWAK/SbWAKL proteins were identified and classified into six phylogenetic groups. The SbWAKs/SbWAKL genes were unevenly distributed across ten chromosomes, and 33 duplications were observed on nine chromosomes. The number of amino acids and molecular weight of SbWAKs/SbWAKLs ranged from 496 to 1149 aa and 55.38 to 124.89 kDa, respectively. Forty‐eight SbWAK/SbWAKL were unstable, with an instability index greater than 40. The synteny analyses revealed sixteen SbWAK/SbWAKL genes similar in foxtail millet, thirteen in maize, and seven in the rice genome. Additionally, 107 miRNAs, including cell wall‐related miRNAs, targeted 85 SbWAK/SbWAKL genes. The cis‐acting elements in SbWAK/SbWAKL genes pointed out that these genes may be associated with light, hormone, development, and environmental stress responses. RT‐qPCR analysis of 13 SbWAK/SbWAKL genes revealed a relatively high transcript fold change in 6 SbWAK/SbWAKL under high‐temperature conditions. In conclusion, cis‐acting elements, protein–protein and miRNA interactions, and higher gene expression levels at high temperatures may indicate the existence of candidate SbWAKs/SbWAKLs genes with functions in abiotic and biotic stress response and their usage in future gene editing for breeding purposes.
An Oldest Record of the Shark Cosmopolitodus planus (Lamnidae) from the Lower Miocene of the Sakhalin, Russia
Authors: Malyshkina T. P. , Nazarkin M. V. , Solovyow A. V. 
Published: December 2023

Abstract
An isolate tooth of a rare extinct hook-toothed mako Cosmopolitodus planus (Agassiz, 1856), discovered in the Lower Miocene deposits of the Chekhov Formation of Sakhalin Island is described. This extinct species was distributed exceptionally in the Pacific basin, and is known mainly from the deposits of the Middle and Upper Miocene. Thus, the described tooth is, probably, the oldest record of this species. The geographic and stratigraphic distribution of this species, as well as the validity of the genus Cosmopolitodus Glickman, 1964, are discussed.
Causal Effects of Basal Metabolic Rate on Cardiovascular Disease: A Bidirectional Mendelian Randomization Study
Authors: Zhao Peng , Han Feiyuan , Liang Xinyu , Meng Li , Yu Bo , Liu Xinxin , Tian Jinwei 
Published: December 2023

Background
Despite the health effects of basal metabolic rate (BMR), the causal effect of BMR on cardiovascular diseases (CVDs) remains undetermined. To elucidate the causal nature, Mendelian randomization (MR) analyses were performed.

Methods and Results

Summary genome‐wide association statistics regarding BMR and 5 CVDs were obtained from European databases. A 2‐sample bidirectional MR was performed to assess the causal association between BMR and CVDs. The causal effects were estimated using inverse variance weighting. Simultaneously, multiple sensitivity analyses were performed to validate the robustness and reliability of the results. Our results indicated that genetically predicted BMR was significantly positively associated with the risk of heart failure (odds ratio, 1.53 [95% CI, 1.39–1.67];
P
<0.001), atrial fibrillation and flutter (odds ratio, 2.12 [95% CI, 1.87–2.40];
P
<0.001), and aortic aneurysm (odds ratio, 1.64 [95% CI, 1.41–1.92];
P
<0.001). Genetically predicted BMR may not be causally associated with coronary artery disease and ischemic stroke risk. Furthermore, a significant causal effect of CVDs on BMR was not found in the reverse MR analysis. Multivariable MR was applied to further assess the direct effect of BMR on CVDs. Multivariable MR indicated that a high level of BMR still increased the risk of heart failure and atrial fibrillation and flutter after adjustment independent of possible confounders. However, the
P
value of aortic aneurysm was not significant.

Conclusions
The present study provides robust evidence that genetically predicted BMR is independently causally associated with heart failure and atrial fibrillation and flutter but not vice versa. These findings have implications for the prevention and treatment of CVDs in clinical practice.
Protecting the Defendant’s Rights in Negotiated Justice Mechanisms – A Comparative Perspective
Authors: Czerwińska Dorota 
Published: December 2023

Abstract
The article analyses the level of procedural protection of a defendant who engages in a discussion regarding the application of negotiated justice solutions in five countries: USA, Germany, France, Italy and Poland. In each of the analysed countries a form of negotiated justice exists, whether it is a classic version of plea bargaining in the USA or a mechanism inspired by plea bargaining but adjusted to continental or inquisitorial setting. These institutions have to provide certain level of protection of the defendant from the risk of making a misinformed or even coerced decision to enter an agreement, in order to assert true voluntariness of the defendant’s waiver of procedural rights. The aim of the paper is to review the procedural safeguards implemented for this purpose and critically assess their effectiveness.
From Grey to Great?
Authors: Vandersmissen Robbe 
Published: December 2023

Abstract
In recent years, the possibilities for aspiring writers who wish to invest in publishing their work without the involvement of an established and external publishing house have grown tremendously. The aim of this article is to look into the global trend of ‘hybrid publishing services’ that operate in the grey zone between traditional publishing and self- publishing. Particular attention is given to the case of Hoi Publishing in Sweden. On the basis of empirical findings on the company’s legal and financial status, company turnover, and symbolic capital, the article examines the status and position of Hoi in relation to similar-sized royalty publishers in order to analyse how its business model fits into the contemporary Swedish literary publishing field. The findings of the case study are supplemented with survey data from 715 authors, publishing professionals, and literary critics, gathered in 2020.
A Typological and Diachronic Analysis of Replication: Body-Part Reflexives in Romance-Lexifier Pidgins and Creoles
Authors: Salaberri Iker , Wolfsgruber Anne C. 
Published: December 2023

Abstract
The fact that body-part reflexives (bpr s) are widespread in Romance-lexifier pidgin, creole and mixed (pcm) languages of the Atlantic area has usually been accounted for in terms of substratum influence from West African languages, in which such reflexives are common. However, this approach does not explain why bpr s are also frequently found in Romance-lexifier pcm languages like Zamboanga Chavacano and Malacca Creole, which lack a demonstrable African substrate, are spoken outside the Atlantic area and are in contact with languages that lack bpr s. Drawing on cross-linguistic as well as historical corpus data, this paper argues that the source of bpr s in these languages should be traced back to the late-medieval and early-Renaissance lexifiers. More specifically, it is proposed that speakers of Romance-lexifier pcm languages identified, recapitulated and replicated reflexive-like uses of words such as ‘body’ and ‘head’ in the lexifiers. A number of bridging contexts is argued to have fostered these processes.
Numerical Simulation of the Kuroshio Flowing over the Hirase Seamount in the Tokara Strait in Autumn: Tidal Vortex Shedding in a Baroclinic Jet
Authors: Inoue Ryuichiro , Tsutsumi Eisuke , Nakamura Hirohiko 
Published: December 2023

Abstract
Idealized numerical simulations of the Kuroshio western boundary current flowing over the Hirase seamount were conducted to examine the mechanisms of phenomena observed by shipboard and mooring measurements. Along the Kuroshio, enhanced mixing [vertical diffusivity, Kρ = O(10−2) m2 s−1] was observed in a low-stratification layer between high-shear layers around low tide, and a V-shaped band of the negative vertical component of relative vorticity (ζz) was also observed. Those features were reproduced in simulations of the Kuroshio that included the D2 tide. In the simulation, a streak of negative ζz detached from the Hirase turned into vertically tilted 10-km-scale vortices. The buoyancy frequency squared (N2) budget at the mooring position showed that the low stratification was caused by vertical and horizontal advection and horizontal tilting. The Kρ tended to increase when the Ertel potential vorticity (PV) < 0, as expected given the inertial instability. However, the magnitude of Kρ also depended on the tidal phase near Hirase, and Kρ was increased in the high vertical shear zones at the periphery of vortices where a strain motion is large. These results indicate that not only inertial instability but also tidal and vertical shear effects are important for driving turbulent mixing.

Significance Statement
A basin-scale distribution of wind stress drives a strong surface-intensified current in the western part of each ocean basin, such as the Gulf Stream and the Kuroshio. This western boundary current is regarded as a place where the kinetic energy and vorticity generated by winds are dissipated, allowing the basin-scale circulation to keep a steady state, but its dissipation mechanisms are not well understood. To understand the mechanisms, we conducted idealized numerical simulations that isolate the interactions between a seamount and the current as well as tidal currents, and compared results with observations. Our findings provide insights into how the current transfers kinetic energy to smaller scales when it flows over a seamount.
Verification of the Global Forecast System, North American Mesoscale Forecast System, and High-Resolution Rapid Refresh Model Near-Surface Forecasts by Use of the New York State Mesonet
Authors: Gaudet Lauriana C. , Sulia Kara J. , Torn Ryan D. , Bassill Nick P. 
Published: December 2023

Abstract
Global Forecast System (GFS), North American Mesoscale Forecast System (NAM), and High-Resolution Rapid Refresh (HRRR) 2-m temperature, 10-m wind speed, and precipitation accumulation forecasts initialized at 1200 UTC are verified against New York State Mesonet (NYSM) observations from 1 January 2018 through 31 December 2021. NYSM observations at 126 site locations are used to calculate standard error statistics (e.g., forecast error, root-mean-square error) for temperature and wind speed and contingency table statistics for precipitation across forecast hours, meteorological seasons, and regions. The majority of the focus is placed on the first 18 forecast hours to allow for comparison among all three models. A daily NYSM station-mean temperature error analysis identified a slight cold bias at temperatures below 25°C in the GFS, a cool-to-warm bias as forecast temperatures warm in the HRRR, and a warm bias at temperatures above 30°C in each model. Differences arise when considering temperature biases with respect to lead times and seasons. Wind speeds are overforecast at all ranges in each season, and forecast wind speeds ≥ 18 m s−1 are rarely observed. Performance diagrams indicate overall good forecast performance at precipitation thresholds of 0.1–1.5 mm, but with a high frequency bias in the GFS and NAM. This paper provides an overview of deterministic forecast performance across New York State, with the aim of sharing common biases associated with temperature, wind speed, and precipitation with operational forecasters and is the first step in developing a real-time model forecast uncertainty prediction tool.
The Rapid Access Memory Program for Addressing Concerns of Incipient Dementia in Academic Primary Care Settings
Authors: Turner Travis H. , Scott Emmi P. , Barlis Katherine , Rodriguez-Porcel Federico , Sartori Andrea C. , Joseph Jane 
Published: December 2023

Background Expedient diagnosis of incipient dementia is often hindered by time constraints in primary care visits, shortage of dementia specialists, and extended waitlists for comprehensive neuropsychological evaluations. Methods We developed the Rapid Access Memory Program (RAMP) to improve access of neuropsychological services for older adults presenting to our institutional primary care clinics with concerns of cognitive decline. RAMP provides abbreviated neurocognitive assessment, same-day patient feedback, expedited reporting to referring providers, and is financially self-supported. Here, we describe development of RAMP and clinical outcomes from the first 3 years. Results Of 160 patients seen, dementia was diagnosed in 30% and Mild Cognitive Impairment in 50%; Alzheimer’s disease was the most common suspected etiology. New psychiatric diagnosis was made in about one-third (n = 54). Most frequent recommendations involved medication adjustments (initiating cholinesterase inhibitors, deprescribing anticholinergics), safety (driving, decision-making), and specialist referrals. Additionally, 27 (17%) subsequently enrolled in local research. Conclusions Results support feasibility and utility of RAMP for connecting older adults in primary care with neuropsychological services.
Quality of Life after Venous Stenting for Post-thrombotic Syndrome and the Effect of Inflow Disease
Authors: Bakas Jay M. , van Montfrans Catherine , Moelker Adriaan , Bos Renate R. van den , Malskat Wendy S. J. , Verhagen Hence J. M. , van Rijn Marie Josee E. 
Published: December 2023

Objective Patients with PTS experience an impaired quality of life (QoL). We aimed to study QoL in patients stented for post thrombotic syndrome (PTS) and analyze the influence of different parameters. Methods Patients stented for PTS after iliofemoral deep vein thrombosis were asked to complete the Chronic Venous Disease Quality of Life Questionnaire (CIVIQ-20) and the Short Form Health Survey (SF-36) in this cross-sectional study. All other data were collected retrospectively. Primary endpoints were median CIVIQ-20 and physical (PCS) and mental (MCS) component summary SF-36 scores. The influence of age, sex, and years between the procedure and completion of questionnaire were investigated using a multivariate linear regression model. Wilcoxon signed rank test compared the PCS and MCS with the normative. Effects of inflow from the deep femoral vein (DFV) and/or the femoral vein (FV) on QoL was analyzed in patients with patent stents. Results The response rate was 70.3% (n = 45/64). Time period (median) from stenting to questionnaire completion was 6.6 years (IQR: 8.0). Most stents were placed unilateral left-sided (73.3%). For patients with patent stents (n = 42) median CIVIQ-20 was 35.5 (IQR: 17.3), higher than the minimum of 20.0 ( P < .001). Median PCS of 44.7 (IQR: 14.2) was lower ( P < .001), and MCS of 55.9 (IQR: 7.1) higher ( P = .001) than the normative (50.0). Time since stenting and sex were not associated with QoL. Age was a significant predictor [standardized coefficient ß = .36, P = .04] for QoL using the CIVIQ-20, but not for the SF-36. Inflow disease did not impact QoL, but patients with occluded stents (n = 3) had poor functioning levels. Conclusion Quality of life is impaired after venous stenting for PTS, particularly physical functioning, among patients with an open stent, but was similar between patients with good and impaired inflow. Patients with a permanent stent occlusion had the lowest QoL.
Trajectories of Forced Migration: Central American Migrants on Their Way Toward the USA
Authors: Pries Ludger , Calderón Morillón Oscar , Estrada Ceron Brandon Amir 
Published: December 2023

Executive Summary Mexico is increasingly important as a country of transit migration between the Global South and the Global North. Migration dynamics from Central America to and through Mexico are mainly considered as economic or mixed migration of people looking for work and a better life in the USA. Nevertheless, since the 2010s the number of asylum applications in Mexico has sky rocketed. Based on a survey of Central American migrants in Mexico we demonstrate that some kind of (organized) violence was a crucial driver for leaving and a constant companion during their journey. After contextualizing the migration route from the Northern Triangle (El Salvador, Guatemala, and Honduras) toward Mexico, we present the design of the study, describe sociodemographic and general contexts of the 350 interviewees, and present the migration trajectories as long-lasting sequences of events and stays, where violence in quite different forms always is at play.