bluuebunny/crossref_metadata_2025_split huggingface dataset:
The rural areas conservancy sites and ecotourism-climate change quandaries: an integrated rural initiative impact on environmental sustainability and livelihoods
Authors: Ramaano Azwindini Isaac 
Published: January 2025

Purpose
This study aims to investigate issues of natural resource management (NRM), conservation and ecotourism leadership on rural livelihood in Musina Local Municipality, Limpopo Province, South Africa. It concentrated on the existing and probable effects of ecotourism and integrated rural activities and their environmental influences on climate change and vice versa, subsistence and sustainability. The study utilizes a broad literature review, focus group discussions and field observations to investigate the municipality’s biodiversity, holistic livelihoods and tourism resource and facility concerns with climate change implications in the study area, with data analyzed manually and also by means of cross tabulations and central tendencies. A harmful link between ecotourism-induced environmental impacts and integrated rural activities that retain potential climate change consequences is found to exist in the vicinity. Nevertheless, it is fathomed in line with the study findings that when tourism actions adhere to the justifications of sustainable and responsible tourism management, they can result in better ecotourism products that foster environmental sustainability and enhance rural livelihoods. Therefore, the study has identified a need for decent ecotourism facilities and activities and a managerial approach to diminish climate change hazards and spur subsistence for local communities in the municipality. Within its rationale and ability, the study presents an analysis of conservation, ecotourism management, environmental degradation and responsible tourism qualities regarding climate change consequences within the municipality.
Isoferulic Acid Inhibits Proliferation and Migration of Pancreatic Cancer Cells, and Promotes the Apoptosis of Pancreatic Cancer Cells in a Mitochondria‐Dependent Manner Through Inhibiting NF‐κB Signalling Pathway
Authors: Sun Suqin , Fan Rong , Chang Li , Gao Lei , Liu Chunting , Liu Dongying , Niu Shiyu 
Published: January 2025

ABSTRACTIsoferulic acid (IA), a derivative of cinnamic acid, is derived from Danshen and exhibits anticancer properties by disrupting cancer cell activities. However, its role in pancreatic cancer, the “king of cancer”, was unknown. In this study, pancreatic cancer cells were subjected to treatment with IA (6.25, 12.5, 25 μM), and nude mice injected with pancreatic cancer cells were received IA at doses of 7.5 mg/kg/day or 30 mg/kg/day by oral administration. CCK8, Annexin V‐FITC/propidium iodide (PI) double staining and TUNEL assay were conducted to evaluate the cell viability and apoptosis. Hoechst staining and comet assay was employed to measure DNA damage. Mitochondrial membrane potential (MMP) analysis was carried out to explain the mitochondrial damage. EdU and wound healing assay were performed for cell proliferation and migration detection. Immunofluorescence and western blot were used to explore the mechanism. We found that IA reduced cell viability and induced apoptosis, as evidenced by an increase in Annexin V‐FITC+PI− and Annexin V‐FITC+PI+ cell populations, brighter TUNEL and Hoechst staining, and more percentage of tail DNA. Furthermore, IA decreased MMP and changed levels of apoptosis‐related proteins. The cell proliferation and migration were inhibited by IA treatment. Mechanically, IA downregulated the phosphorylation of IĸBα and inhibited p65 nuclear translocation, consequently suppressing NF‐κB pathway. In general, IA suppressed the cell proliferation and migration, and caused apoptosis of pancreatic cancer cells in a mitochondria‐dependent manner through blocking NF‐κB signalling pathway, indicating that IA may be a potential therapeutic strategy for pancreatic cancer.
Regulation of Rhizobial Nodulation Genes by Flavonoid‐Independent NodD Supports Nitrogen‐Fixing Symbioses With Legumes
Authors: Haskett Timothy L. , Cooke Louise , Green Patrick , Poole Philip S. 
Published: January 2025

ABSTRACTRhizobia and legumes form a symbiotic relationship resulting in the formation of root structures known as nodules, where bacteria fix nitrogen. Legumes release flavonoids that are detected by the rhizobial nodulation (Nod) protein NodD, initiating the transcriptional activation of nod genes and subsequent synthesis of Nod Factors (NFs). NFs then induce various legume responses essential for this symbiosis. Although evidence suggests differential regulation of nodD expression and NF biosynthesis during symbiosis, the necessity of this regulation for the formation of nitrogen‐fixing nodules remains uncertain. Here, we demonstrate that deletion of the Rlv3841 NodD regulatory domain results in a constitutively active protein (NodDFI) capable of activating NF biosynthesis gene expression without the presence of flavonoids. Optimised constitutive expression of nodDFI or nodD3 in nodD null mutants led to wild‐type levels of nodulation and nitrogen fixation in pea and M. truncatula, respectively, indicating that flavonoid‐regulated nodD expression is not essential for supporting symbiosis. These findings illustrate that transcriptional control of flavonoid‐independent NodD regulators can be employed to drive NF biosynthesis, which holds potential for engineering symbiosis between rhizobia and cereals equipped with reconstituted NF receptors.
Systematic review on flexi‐schooling of autistic students
Authors: Richter Mechthild , Nishnik Julian , Borrmann Alina , Grummt Marek , Lindmeier Christian 
Published: January 2025

AbstractFlexi‐schooling, an approach involving at least some instruction both at home and at school, has potential to adapt education to meet the needs of autistic students while also providing in‐person school benefits. This systematic international literature review of flexi‐schooling for autistic students aims to understand the advantages and disadvantages of this practice, why flexi‐schooling is chosen and the factors for a successful implementation. Eight hundred and fifty‐five studies were screened, of which eight met the search criteria and were analysed using thematic analysis. Flexi‐schooling is seen as a way to provide autistic students with an education that is constructed to meet individual needs and is flexible enough to address changes. Nevertheless, it can also be a challenging process that requires commitment, trust and additional effort from parents and teachers and may face various barriers. Flexi‐schooling can be difficult to implement due to power imbalances between school and home and a lack of communication and cooperation. Flexi‐schooling is an idea that has not yet been widely implemented in practice, and there is little information available about how it is put into action. Although it is rarely a first choice, it is often considered as a positive solution to a challenging and constantly changing situation.
Microbial Communities in Agave Fermentations Vary by Local Biogeographic Regions
Authors: Jara‐Servin Angélica , Alcaraz Luis D. , Juarez‐Serrano Sabino I. , Espinosa‐Jaime Aarón , Barajas Ivan , Morales Lucia , DeLuna Alexander , Hernández‐López Antonio , Mancera Eugenio 
Published: January 2025

ABSTRACTThe production of traditional agave spirits in Mexico, such as mezcal, involves a process that uses environmental microorganisms to ferment the cooked must from agave plants. By analysing these microorganisms, researchers can understand the dynamics of microbial communities at the interface of natural and human‐associated environments. This study involved 16S and ITS amplicon sequencing of 99 fermentation tanks from 42 distilleries across Mexico. The Agave species used, production methods, climatic conditions and biogeographic characteristics varied significantly among sites. However, certain taxa were found in most fermentations, indicating a core group of microorganisms common to these communities. The primary variable consistently associated with the composition of both bacterial and fungal communities was the distillery, suggesting that local production practices and site‐specific attributes influence the microbiomes. The fermentation stage, climate and producing region also affected community composition but only for prokaryotes. Analysis of multiple tanks within three distilleries showed taxa enriched in specific fermentation stages or agave species. This research provides a detailed analysis of the microbiome of agave fermentations, offering important knowledge for its management and conservation.
The Predictive Ability of Taxable Income for Future Performance: The Impact of High Tax Planning*
Authors: Chen Yong Qiang , Niu Flora , Zeng Tao 
Published: January 2025

ABSTRACTThis research examines whether high tax planning affects the predictive ability of taxable income for firms' future operating performance. Using US‐listed firms for the period 1988 to 2016, this study finds that high tax planning reduces the ability of taxable income to predict future performance, measured as 1‐, 2‐, and 3‐year‐ahead operating cash flows. It also shows that high tax planning decreases the incremental predictive value of taxable income for future performance beyond book income and operating cash flows. This study contributes to the existing literature on the informative nature of taxable income and enhances our understanding of how tax planning affects the information content of taxable income, particularly its predictive ability for firms' future performance. These findings suggest that, when using taxable income to predict future performance, financial statement users should consider the level of aggressiveness in firms' tax planning activities.
Words to live by: Using medic impressions to identify the need for prehospital lifesaving interventions
Authors: Weidman Aaron C. , Sedor‐Schiffhauer Zach , Zikmund Chase , Salcido David D. , Guyette Francis X. , Weiss Leonard S. , Poropatich Ronald K. , Pinsky Michael R. 
Published: January 2025

AbstractBackgroundPrehospital emergencies require providers to rapidly identify patients’ medical condition and determine treatment needs. We tested whether medics’ initial, written impressions of patient condition contain information that can help identify patients who require prehospital lifesaving interventions (LSI) prior to or during transport.MethodsWe analyzed free‐text medic impressions of prehospital patients encountered at the scene of an accident or injury, using data from STAT MedEvac air medical transport service from 2012 to 2021. EMR records were used to identify LSIs performed for these patients in prehospital settings. Text was cleaned via natural language processing and transformed using term frequency–inverse document frequency. A gradient boosting machine learning (ML) model was used to predict individual patient need for prehospital LSI as well as seven LSI subcategories (e.g., airway interventions, blood transfusion, vasopressor medication).ResultsA total of 12,913 prehospital patients were included in our sample (mean age = 52.3 years, 63% men). We observed good ML performance in predicting overall LSI (area under the receiver operating curve = 0.793, 95% confidence interval = [0.776–0.810]; average precision = 0.670, 95% confidence interval = [0.643–0.695] vs. LSI rate of 0.282) and equivalent‐or‐better performance in predicting each LSI subcategory except for crystalloid fluid administration. We identified individual words within medic impressions that portended high (e.g., unresponsive, hemorrhage) or low (e.g., droop, rib) LSI rates. Calibration analysis showed that models could prioritize correct LSI identification (i.e., high sensitivity) or accurate triage (i.e., low false‐positive rate). Sensitivity analyses showed that model performance was robust when removing from medic impressions words that directly labeled an LSI.ConclusionsML based on free‐text medic impressions can help identify patient need for prehospital LSI. We discuss future work, such as applying similar methods to 9‐1‐1 call requests, and potential applications, including voice‐to‐text translation of medic impressions.
Drivers and concerns of adopting Artificial Intelligence in managerial accounting
Authors: Zhang Chao , Zhu Weidong , Dai Jun , Wu Yong , Chen Xulong 
Published: January 2025

AbstractRecent advancements in Artificial Intelligence (AI) have attracted significant attention within the managerial accounting profession. With its transformative capabilities and complexity, AI presents numerous opportunities alongside notable challenges in its adoption. This paper examines the key factors influencing AI adoption in managerial accounting and highlights common concerns faced by companies during this process. Based on interviews with representatives from 41 companies, we identified a range of factors impacting AI adoption at both institutional and individual levels. These findings offer valuable insights into AI acceptance within the field of managerial accounting.
Wolf's Isotopic Response: Acquired Arteriovenous Haemangioma Following Oral Herpes Simplex Virus Infection
Authors: Tran Vanessa , Morgan Vanessa , Scardamaglia Laura 
Published: January 2025

ABSTRACTCutaneous arteriovenous haemangioma (AVH) is a rare benign vascular lesion, which typically occurs on the head and neck. Its aetiology is unclear but thrombosis, trauma, infection or endocrine triggers have been proposed. We report the case of a 64‐year‐old female presenting with acquired AVH of the upper lip following oral herpes simplex virus infection. This is the first documented occurrence of AVH as a post‐herpetic isotopic response (PHIR).
Sick Day Management Plans for Aboriginal and/or Torres Strait Islander Peoples With Chronic Kidney Disease on the Cape York Peninsula of Australia: Health Workers' Perspectives
Authors: Calleja Luke , Glass Beverley , Taylor Selina , Neville Kisha , Brown Leanne , Miller Andrea , Cairns Alice 
Published: January 2025

ABSTRACTObjectiveThis study aimed to explore the perspectives of healthcare professionals on the utility of sick day management plans for people with chronic kidney disease (CKD) in remote communities and collaboratively design a sick day management plan resource.DesignThis qualitative study utilised two phases of data collection: preliminary observational data and semi‐structured interviews. The research design and analysis were guided by the normalisation process theory (NPT) framework, tailored for complex interventions in healthcare.SettingThree First Nations communities and one remote mining community in Cape York, Australia.ParticipantsIn‐person semi‐structured interviews were conducted with 23 primary healthcare workers; 40% identified as Aboriginal and/or Torres Strait Islander.ResultsThe study identified three themes relating to feasibility of implementation: (1) resource coherence and readability, (2) suitability for integration into the care model and (3) safety and risk associated with sick day management plans. Iterative development of resources followed, incorporating feedback from the participants. Recommendations emerged for enhanced readability and coherence, including further co‐design with individual communities and consumers, content simplification, incorporation of Aboriginal and/or Torres Strait Islander artwork and language and a flow chart structure.ConclusionThe study underscores the importance of culturally sensitive resource design and the active involvement of Aboriginal and/or Torres Strait Islander communities in healthcare improvement. Future research should explore cost‐effective methods for personalised sick day management plans.
Language proficiency and cultural intelligence: A meta‐analysis based on conservation of resources theory and the overt‐covert model of culture
Authors: Ng Kok Yee , Rockstuhl Thomas , Ang Soon 
Published: January 2025

AbstractResearch on language proficiency and cultural intelligence (CQ) has developed somewhat independently, resulting in a partial understanding of the personal resources required to facilitate job performance and adaptation in a foreign culture. Our meta‐analysis synthesizes the two constructs by drawing on the overt‐covert model of culture and the conservation of resources (COR) theory. Specifically, we propose that language proficiency and CQ complement each other by overcoming resource losses arising from overt (i.e., explicit language differences) and covert (i.e., implicit rules) cultural differences, respectively. We further propose that the host‐country communication context (i.e., higher vs. lower context dependence) moderates the effects of language proficiency and CQ. Meta‐analytic results based on 355 field samples (N = 128,358) support our hypotheses and show that (1) both language proficiency and CQ are positively related to job performance and cultural adaptation, (2) the effects of language proficiency are accentuated in cultures with lower communication‐context dependence, while (3) the effects of CQ are accentuated in cultures with higher communication‐context dependence. We discuss the implications of these findings for future research and practice.
When Does Corporate Social Responsibility Backfire? Intentional Crises and the Insurance Value of CSR
Authors: Zhang Danni , Dong Yusen , Liu Chunlin 
Published: January 2025

ABSTRACTDrawing on attribution theory and expectancy violation theory, this study investigates the effect of corporate social responsibility (CSR) on stock market reactions in the context of intentional crises, during which stakeholders are likely to attribute crisis responsibility to the focal firm. Using a sample of Chinese listed firms from 2012 to 2022, we find that in the context of an intentional crisis, the stock market reacts more negatively to firms with higher prior CSR performance. Two contingency factors (i.e., media attention and state ownership) strengthen this negative relationship. This study contributes to the CSR literature by broadening knowledge of the insurance‐like effects of CSR and by identifying a “boomerang effect” of CSR in the context of intentional crises.
Comparing open and video endoscopic lymphadenectomy for penile cancer: a systematic review and meta‐analysis of prospective studies
Authors: Suartz Caio Vinícius , de Lima Richard Dobrucki , Abud Luiza Rafih , Brito Pedro Henrique Souza , Galhardo Ketlyn Assunção , Talizin Thalita Bento , Salazar André Lopes , Korkes Fernando , Guglielmetti Giuliano , de Cássio Zequi Stênio , Ribeiro‐Filho Leopoldo Alves , Toren Paul , Lodde Michele 
Published: January 2025

ObjectiveTo conduct the first meta‐analysis using only prospective studies to evaluate whether video endoscopic inguinal lymphadenectomy (VEIL) offers advantages in perioperative outcomes compared to open IL (OIL) in patients with penile cancer.MethodsA systematic review with meta‐analysis was conducted across multiple databases, including Cochrane Central Register of Controlled Trials (CENTRAL), the Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE), Latin America and Caribbean Health Sciences Literature (LILACS), Scopus, Web of Science, and several trial registries up to June 2024. Only randomised controlled trials (RCTs) and prospective cohort studies were included. Data extraction focused on operative time, perioperative complications, drainage time, hospital stay, number of nodes retrieved and oncological outcomes.ResultsFour prospective studies, including three RCTs and one non‐randomised study, were included in the analysis, totalling 95 patients and 174 operated limbs. VEIL demonstrated significantly fewer wound infections (P < 0.001; 95% confidence interval [CI] 0.01–0.18; I2 = 0), skin necrosis (P = 0.002; 95% CI 0.04–0.49; I2 = 0), and lymphoedema (P = 0.05; 95% CI 0.09–0.99; I2 = 27%) compared to OIL. The VEIL group also had a shorter drainage period (P = 0.001; mean difference [MD] –1.94, 95% CI −3.15 to −0.74) and hospital stay (P < 0.01; MD –5.48, 95% CI −6.34 to −4.62). Pain intensity and operative time were lower in the VEIL group, contributing to fewer postoperative complications overall. Oncological outcomes showed no significant differences between the groups.ConclusionThe meta‐analysis indicates that VEIL offers significant advantages over OIL in terms of reducing wound infections, skin necrosis, and lymphoedema, leading to shorter hospital stays and overall improved perioperative outcomes. However, the limited sample of 95 patients across four studies underscores the need for further randomised trials and a cautious interpretation of the results, which currently support the use of VEIL in managing patients with penile cancer.
Fluid intake and recurrence and progression risk of patients with non‐muscle‐invasive bladder cancer
Authors: Beeren Ivy , Meijer Hilde , van der Heijden Antoine G. , Aben Katja K.H. , Witjes J. Alfred , Kiemeney Lambertus A.L.M. , Vrieling Alina 
Published: January 2025

ObjectivesTo evaluate the association of pre‐ and post‐diagnosis fluid intake with non‐muscle‐invasive bladder cancer (NMIBC) recurrence and progression risk.Patients and MethodsData were used from the multicentre prospective cohort study UroLife. Participants reported pre‐diagnosis fluid intake at 6 weeks (food frequency questionnaire [FFQ]) (n = 1322) and post‐diagnosis fluid intake at 3 and 15 months (FFQ and 4‐day 24‐h fluid diaries) (n = 1275) after diagnosis. Multivariable proportional hazard regression models were used to obtain hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of fluid intake with risk of first and multiple recurrence(s) and progression.ResultsDuring a median overall follow‐up of 4.6 years, 474 patients had one or more recurrence and 142 had progression. A higher first recurrence risk was observed for patients with the highest pre‐diagnosis fluid intakes (≥2300 vs 1500–1900 mL/day: HR 1.38, 95% CI 1.07–1.79), but not for those with the highest post‐diagnosis fluid intakes. HRs were similar for multiple recurrence risk. For progression, each 150 mL/day increase in both pre‐ and post‐diagnosis fluid intake was consistently associated with an increased risk (post‐diagnosis [3 months] FFQ‐based: HR 1.05, 95% CI 1.01–1.09 and diary‐based: HR 1.04, 95% CI 0.99–1.09).ConclusionHigh fluid intakes may be associated with higher NMIBC recurrence and especially progression risk. These findings lack a clear explanation but may be related to extensive expansion of the bladder wall or urinary symptoms. Further research is warranted. Meanwhile, these findings do not support recommending high(er) fluid intakes to patients with NMIBC to decrease their recurrence or progression risk.