bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic effects of essential oils and phenolic extracts on antimicrobial activities using blends of Artemisia campestris, Artemisia herba alba, and Citrus aurantium
Authors: Benamar-Aissa Boualem , Gourine Nadhir , Ouinten Mohamed , Yousfi Mohamed 
Published: February 2024

Abstract
This study explores the synergistic antibacterial effects of essential oils (EOs) and phenolic extracts from three plants against foodborne pathogenic bacteria. The present work aimed to investigate the synergistic effects of the binary and the ternary combinations of extracts using different blend proportions of the following plant extracts: Artemisia campestris (AC), Artemisia herba alba (AHA), and Citrus aurantium (CA). The antimicrobial activities of EOs and phenolic extracts were determined and evaluated against five strains. For the EOs, the results of the DIZ showed the existence of synergism for different combinations of binary blends, such as AC/AHA or AHA/CA against Escherichia coli, and AC/CA against Enterobacter faecalis. In addition, ternary blends of AC:AHA:CA at a ratio of 1/6:2/3:1/6 exhibited a synergy effect, as measured by the CI, against E. coli. On the other hand, for the phenolic extracts, synergistic effects were noticed for binary blends of AC/CA at different ratios against E. coli, E. faecalis, and Pseudomonas aeruginosa strains. Similarly, ternary blends of phenolic extracts presented synergy against E. coli, E. faecalis, P. aeruginosa strains, and even C. albicans. In this case, the blending ratios were crucial determining factors for maximizing the synergy effect. The study established that the proportion of a single drug could play an essential role in determining the bioefficacy of a drug combination treatment. Therefore, the results showed the importance of studying the modulation of antibacterial activities based on the proportions of extracts in the mixture and finding the range of proportions (as determined by SLMD) that have a synergistic/additive/antagonistic effect with no or low side effects, which can be used in a food preservation system.
Environmental gradients influence geographic differentiation and low genetic diversity of morphologically similar Ulva species in the Northwest Pacific
Authors: Zhong Kai-Le , Hiraoka Masanori , Gao Xu , Russell Bayden , Hu Zi-Min , Chen Weizhou , Kim Ju-Hyoung , Yotsukura Norishige , Endo Hikaru , Oka Naohiro , Yoshikawa Shinya , Gaitan-Espitia Juan Diego 
Published: February 2024

Abstract
Species classified in the genus Ulva are important foundational marine primary producers distributed worldwide. These species are particularly abundant and diverse through the northwest Pacific (NWP) where they experience marked latitudinal gradients of environmental heterogeneity. It is unclear, however, to what extent such dynamic conditions can modulate phenotypic and genetic patterns in these organisms, potentially reflecting the influence of historical and contemporary biotic and abiotic factors. Here, we assessed inter- and intra-specific genetic patterns of Ulva species through the NWP using plastid rbcL and tufA gene sequences. Although we initially targeted Ulva australis based on morphological identification, we recovered eight Ulva genetic entities masked by morphological similarities. Except for the Ulva linza–procera–prolifera and U. lactuca–reticulata complexes, six of these genetic entities were recovered as individual species (i.e., U. australis, U. ohnoi, U. californica, U. compressa, U. lacinulata, and U. arasakii), and showed biogeographic patterns likely explained by clines in sea surface temperature and ocean current dispersal. At intra-specific level, all the genetic entities showed low genetic variation and divergence based on rbcL (0–0.3 %) and tuf A (0–0.9 %) data. Our results provide insights regarding intra- and inter-specific genetic patterns characterizing morphologically similar Ulva species through the NWP. However, further studies are needed to understand the mechanisms underpinning such patterns and the associated ecological and evolutionary implications.
Stability of ten serum tumor markers after one year of storage at −18°C
Authors: Mondésert Etienne , De Brauwere David-Paul , Lumbroso Serge , Brouillet Jean-Paul , Bancal Candice 
Published: February 2024

Abstract

Objectives
The storage of serum tumor markers (STM) at −18 °C for one year has been a legal requirement in France since 1999, but has been abolished in 2022. This raises the question of the relevance of maintaining these biobanks in terms of conditions of storage. These should only be implemented after validation; in order to maintain the integrity of the biological sample and must be controlled over time according to the laboratoryʼs procedures. The aim of the study was to assess the suitability of storing 10 STMs by evaluating their stability after one year of storage at −18 °C.

Methods
A new immuno-enzymatic assay (A+1) was conducted on samples that had been stored at −18 °C for one year after an initial assay (A) of one of the following STMs: carcino-embryonic antigen (CEA), alpha-fetoprotein (AFP), carbohydrate antigen 125 (CA125), carbohydrate antigen 15-3 (CA15-3), carbohydrate antigen 19-9 (CA19-9), total (TPSA), and free (FPSA) prostate-specific antigen, calcitonin (CT), thyroglobulin (TG), and neuro-specific enolase (NSE). The results were confronted to four different permissible error sources.

Results
In total, 1148 A+1 assays were performed. A strong correlation between A+1 and A values was found for all analytes, but with a statistically significant reduction in the mean A+1 concentration compared to the mean A concentration in 7/10 STMs. The bias induced by conservation seems to be technically unsustainable if we rely on the repositories closest to the current analytical performances.

Conclusions
These results support the discontinuation of mandatory STM biobank storage at −18 °C, which requires considerable technical time and organizational effort.
The rheological, textural, frictional, and digestive properties of starch-based cheese analogs prepared with tapioca starch and almond protein
Authors: Li Peijiao , Wen Yanwen , Qiu Xiaomin , Chen Douyi , Zou Yuan , Zheng Qianwang 
Published: February 2024

Abstract
Most commercial starch-based cheese analogs were pointed out that protein content is low, but protein can affect the formation of the starch gel and its sensory properties. Almond proteins have high nutritional values because they are abundant in essential amino acids. In this study, the effects of different tapioca starch/almond protein proportions on the starch-based cheese analogs texture, rheology, friction and digestion properties were studied. The addition of almond protein to starch-based cheese analogs resulted in soft texture, small storage modulus values, increased friction coefficients, and increased fat digestibility as the proportion of protein increased. When increase the starch proportion, an opposite trend was observed. These findings showed that protein-supplemented starch-based cheese analogs with tunable texture, rheological, frictional and digestive properties can be easily produced by controlling the proportion of tapioca starch/almond protein.
Horner syndrome immediately after deep dissection of upper thyroid pole: a case report and review of the literature
Authors: Chen Hongdan , Sun Yiceng , Tang Mi , Zhang Fan 
Published: February 2024

Abstract

Objectives
Horner syndrome (HS) is a rare complication of thyroid surgery. However, the relationship between the occurrence of HS and thyroid upper pole injury is still not completely clear, and there are only few reports.

Case presentation
A 24-year-old female underwent endoscopic thyroidectomy for thyroid papillary carcinoma. The intraoperative examination found that the upper pole of the thyroid was bleeding. During hemostasis, the ultrasonic knife consciously peeled too deep and stopped. The patient developed HS immediately after operation. We analyzed the association between deep dissection of the upper thyroid pole and an increase in the HS incidence rate through literature searches and anatomical relationships.

Conclusions
Our case report discussed the potential relationship between the degree of thyroid upper pole dissection and the occurrence of HS in routine thyroid surgery, and provided a warning for the degree of thyroid upper pole dissection in the clinic to avoid HS.
The assessment of the mechanism of action of lauric acid in the context of oral cancer through integrative approach combining network pharmacology and molecular docking technology
Authors: Buva Kirti , Kumbhar Gauri M. , Deshmukh Ajinkya , Ladke Vaibhav Sunil 
Published: February 2024

Abstract

Objectives
Lauric acid has been investigated for its effects on various human cancer cell types, although limited research has been dedicated to its impact on oral cancer. In light of this, the objective of our study was to comprehensively assess the anticancer properties of lauric acid specifically in the context of oral cancer. This evaluation was achieved through an in-silico approach, leveraging network analysis techniques. By employing this methodology, we aimed to gain valuable insights into the potential therapeutic benefits of lauric acid for treating oral cancer.

Methods
The in-silico analysis involved determination of drug-likeness prediction, prediction of common targets between oral cancer and LA, protein–protein interactions (PPI), hub genes, top 10 associated pathways by gene ontology (GO), Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway, molecular docking experiments.

Results
Our study pinpointed 23 common genes involved in critical cellular processes, including proliferation, apoptosis regulation, PI3K AKT cascade, and cell cycle control. Among them, CXCL8, MMP9, PPARA, MAPK1, and AR stood out in the top 10 pathways, particularly in the PI3K/AKT signaling pathway. This highlights the potential role of lauric acid in oral cancer treatment through the PI3K/AKT pathway and calls for further exploration of this mechanism.

Conclusions
Our study highlights lauric acid’s promising anticancer properties through computational analysis, offering a foundation for future research in cancer treatment development. This approach combines molecular insights with in-silico methods, paving the way for identifying therapeutic compounds and understanding their mechanisms. Lauric acid holds potential as a chemotherapeutic agent, opening up new avenues for cancer therapy exploration.
Cardiorespiratory response patterns during multifunctional imagery-assisted biofeedback training – a case study
Authors: Roy Jolly , Athrey Aravind , Xavier Cheryl , Sonar Samruddhi 
Published: February 2024

Abstract

Objectives
The study aimed to expand the knowledge of cardiorespiratory response patterns while engaging in multifunctional imagery-assisted biofeedback training in a young cricketer.

Methods
The athlete was asked to engage in imagery (e.g. facing the bowler in an over: six ball) and cardiorespiratory responses were monitored using biofeedback equipment. The study involved a total of 19 sessions. Phases 1 & 2 focused on need analysis and action plan respectively and phases 3 to 5 focused on imagery–assisted biofeedback training viz. Motivational Specific-MS (six sessions); Motivational General-Mastery MG-M (six sessions); Cognitive Specific-CS-PETTLEP (7 sessions). The qualitative feedback was taken after each session from phases 3 to 5.

Results
A higher heart rate (HR) was observed while facing the second ball in an over during MS (83 % of the time) and MG-M type of imagery (50 % of the time). While doing CS imagery, the higher HR was observed while facing the fifth ball in an over (57 % of the time). No consistent pattern was observed in the respiration rate (RR) while engaging in imagery training. The athlete’s feedback revealed that in MS and MG-M, the initial attention was on staying focused while facing the bowler. During the CS imagery, the difference in the HR patterns probably happened because the athlete focused on appropriate skill execution.

Conclusions
Understanding an athlete’s cardiorespiratory patterns can be helpful in training an athlete's self-regulation to reach the optimal zone of functioning.
Differential experiments using parallel alternative operations
Authors: Calderini Marco , Civino Roberto , Invernizzi Riccardo 
Published: February 2024

Abstract
The use of alternative operations in differential cryptanalysis, or alternative notions of differentials, is lately receiving increasing attention. Recently, Civino et al. managed to design a block cipher that is secure with respect to the classical differential cryptanalysis performed using XOR-differentials, but weaker with respect to the attack based on an alternative difference operation acting on the first s-box of the block. We extend this result to parallel alternative operations, i.e. acting on each s-box of the block. First, we recall the mathematical framework needed to define and use such operations. After that, we perform some differential experiments against a toy cipher and compare the effectiveness of the attack with respect to the one that uses XOR-differentials.
Optimization analysis of an endoreversible quantum heat engine with efficient power function
Authors: Kaur Kirandeep , Jain Anmol , Singh Love Sahajbir , Singla Rakesh , Rebari Shishram 
Published: February 2024

Abstract
We study the optimal performance of an endoreversible quantum dot heat engine, in which the heat transfer between the system and baths is mediated by qubits, operating under the conditions of a trade-off objective function known as the maximum efficient power function defined by the product of power and efficiency of the engine. First, we numerically study the optimization of the efficient power function for the engine under consideration. Then, we obtain some analytic results by applying a high-temperature limit and compare the performance of the engine at maximum efficient power function to the engine operating in the maximum power regime. We find that the engine operating at maximum efficient power function produces at least 88.89 % of the maximum power output while at the same time reducing the power loss due to entropy production by a considerable amount. We conclude by studying the stochastic simulations of the efficiency of the engine in maximum power and maximum efficient power regime. We find that the engine operating at maximum power is subjected to fewer power fluctuations as compared to the one operating at maximum efficient power function.
Diagnosis and approach of pseudohypoparathyroidism type 1A and related disorders during long term follow-up: a case report
Authors: Expósito Raspeño Mónica , Sánchez Escudero Verónica , Pérez de Nanclares Leal Guiomar , Ortiz Santamaría María , Sánchez-Dehesa Sáez Rosa , García Cuartero Beatriz , González Vergaz Amparo 
Published: February 2024

Abstract

Objectives
Pseudohypoparathyroidism type 1A (PHP1A) encompasses the association of resistance to multiple hormones, features of Albright hereditary osteodystrophy and decreased Gsα activity. Little is known about the early signs of PHP1A, with a delay in diagnosis. We report two PHP1A cases and their clinical and biochemical findings during a 20-year follow-up.

Case presentation
Clinical suspicion was based on obesity, TSH resistance and ectopic ossifications which appeared several months before PTH resistance, at almost 3 years of age. Treatment with levothyroxine, calcitriol and calcium was required in both patients. DNA sequencing of GNAS gene detected a heterozygous pathogenic variant within exon 7 (c.569_570delAT) in patient one and a deletion from XLAS to GNAS-exon 5 on the maternal allele in patient 2. In patient 1, ectopic ossifications that required surgical excision were found. Noticeably, patient 2 displayed adult short stature, intracranial calcifications and psychomotor delay. In terms of weight, despite early diagnosis of obesity, dietary measures were established successfully in both cases.

Conclusions
GNAS mutations should be considered in patients with obesity, ectopic ossifications and TSH resistance presented in early infancy. These cases emphasize the highly heterogeneous clinical picture PHP1A patients may present, especially in terms of final height and cognitive impairment.
The traumatic narratives of sexuality in Taiwanese writer Shao-Lin Chu’s trilogy
Authors: Tsai Hsiu-Chih 
Published: February 2024

Abstract
This paper explores the narratives of the Taiwanese woman novelist Shao-Lin Chu’s trilogy to see how the problem of female sexuality and resistance to parental wedlock tragedy becomes a traumatic experience. The traumatic symptoms in the narratives are taken as Peircean signs for tracing the negative influences of traumatic experiences on the formation of personal identity and the associated depressive disorder. The scenes portrayed in Chu’s traumatic narratives of female and male sexuality are implications and representations of how sexuality is conceptualized and confined by the traumatic events while backgrounded with regulations and restrictions of a traditional society. The stories of Chu’s female narrators reveal the persistent and resisting feminine power. This paper adopts the concept of feminist narrative to analyze the traumatic and sexual events in Chu’s trilogy. The decoding and re-encoding of resistance and sexuality in the traumatic narratives prove that the narratological textual analysis and semiotic reading strategy together offer a solid approach to the discovery of the persistent traumatic impacts of the secret veiled in the narratives and reveal the probable strength of compassion that has its roots derived from deplorable trauma but later transforms itself to stimulate a positive reconstruction of the traumatic survivors’ identity.
Null and overt se constructions in Brazilian Portuguese and the network of se constructions
Authors: Afonso Susana , Soares da Silva Augusto 
Published: February 2024

Abstract
Middle voice (MV) comprises a set of marked constructions associated with situation types (Kemmer 1993. The middle voice. Amsterdam: John Benjamins), in which the middle marker functions as an intransitivizer. MV constructions in Portuguese are se constructions in which the clitic se is typically overt, but in Brazilian Portuguese there is variation between constructions with and without the clitic marker. The overt-null variation is observed in all se construction types and it has been argued by Soares da Silva et al. (2021. Null se constructions in Brazilian and European Portuguese: Morphosyntactic deletion or emergence of new constructions? Cognitive Linguistics 32(1). 159–193) that differences in conceptualization of an event as “energetic” or “absolute” primarily drive the variation. This article focuses on the (re)configuration of the network of se constructions in light of the overt-null alternation. Given that the alternation is systematic for all types of se construction, we propose that both the marked and unmarked constructions are plotted onto the conceptual map of MV constructions. As to the introduction of the null variant in the taxonomy of se constructions, we argue that the overt-null variants are allostructions posited at lower levels of abstraction. We also hypothesize that the middle marker at the top node is underspecified for function, instantiated as an intransitivizer, or lexically defined at the immediate subordinate level.
The crystal structure of diethyl 1,4-dihydro-2,6-dimethyl-4-(3-cyanophenyl)-3,5-pyridinedicarboxylate, C20H22N2O4
Authors: Li Zhang , Hai-yan Yu , Ying-lei Wang , Ke-nan Sun , Ye Tian 
Published: February 2024

Abstract
C20H22N2O4, monoclinic, P21/n (no. 14), a = 11.4033(15) Å, b = 14.2998(16) Å, c = 11.6486(16) Å, β = 91.197(8)°, V = 1899.1(4) Å3, Z = 4, R

gt
(F) = 0.0513, wR

ref
(F
2) = 0.1542, T = 296.2 K.
Crystal structure of 3-(5-((4-(difluoromethoxy)phenyl) sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl) oxetane-3-carboxamide, C17H19F2N3O5S
Authors: Liu Bin , Xu Xiaona , Tong Hongjuan , Wang Yanjiao , Zhu Zhoujing 
Published: February 2024

Abstract
C17H19F2N3O5S, monoclinic, P21/c (no. 14), a = 14.157(7) Å, b = 11.133(6) Å, c = 11.400(6) Å, β = 91.965(13)°, V = 1795.6(16) Å3, Z = 4, R

gt
(F) = 0.0611 wR

ref
(F
2) = 0.1809, T = 205 K.
The crystal of structure of (OC-6-22)-pentakis(acetonitrile)bromidoruthenium(II)bromide monohydrate, C10H15Br2N5Ru
Authors: Tapala Kgaugelo C. , Clayton Hadley S. 
Published: February 2024

Abstract
C10H15Br2N5Ru, orthorhombic, P212121 (no. 19), a = 7.9081(4) Å, b = 8.4334(4) Å, c = 25.9374(13) Å, V = 1729.82(15) Å3, Z = 4, R

gt
(F) = 0.0637, wR

ref
(F
2) = 0.1579, T = 173(2) K.
Crystal structure of catena-poly[aqua-(μ
2-1,4-diazabicyclo[2.2.2]octane-k2
N: N′)-bis(sorbato-κ
1
O)-copper(II), C18H28CuN2O5
Authors: Shin Minkyun , Kang Jaeun , Ok Kang Min , Do Junghwan 
Published: February 2024

Abstract
C18H28CuN2O5, orthorhombic, Pmmn (no. 59), a = 6.8107(1) Å, b = 24.3351(5) Å, c = 6.0304(1) Å, V = 999.47(3) Å3, Z = 2, R
gt(F) = 0.0266, wR
ref(F
2) = 0.0676, T = 296(2) K.
Catalytic destruction of oxalate in the supernatant stream generated during plutonium reconversion process
Authors: Prasad Arvind , Vijayan Kadukkappilly S. , Rao Ravinuthala V. S. , Narasimhan Desigan , Krishnamoorty Ananthasivan 
Published: February 2024

Abstract
Plutonium oxalate supernatant requires a treatment step for further recovery of the residual Pu. As the oxalate ion present in the solution poses problems during the recovery of Pu, it needs to be destroyed. In the present work, Mn2+ based catalytic destruction of oxalate ion was studied in detail, as it could minimize the generation of secondary radioactive waste compared to the conventional process. The effect of various parameters, namely concentrations of HNO3, catalyst, oxalic acid and effect of the metal ion has been studied. Moreover, the robustness of the catalytic destruction method along with the kinetics of oxalate destruction reaction has been investigated. The process was also demonstrated with Pu supernatant generated from CORAL at 1 L scale.
210Pb dating and neutron activation analysis of the Sundarban mangrove sediments: sedimentation rate and metal contamination history
Authors: Islam Mohammad Amirul , Kabir Shaiful , Lubis Ali Arman , Sugiharto Untung , Islam M. Moinul , Hossen Mohammad Belal 
Published: February 2024

Abstract
In this study, alpha spectrometry and neutron activation analysis were applied to assess the mass accumulation rate, contamination history, and ecological risk of the Sundarban mangrove sediments. The mass accumulation rates of sediments using 210Pb dating determined for the first time in this area ranged from 0.068 to 3.20 kg m−2 y−1, with an average of 0.61 kg m−2 y−1. The contamination history of 11 metal(loid)s (Al, Ca, V, Cr, Fe, Ni, Cu, Zn, As, Hg, and Pb) was assessed. Different environmental contamination indices suggested that Sundarban mangrove sediments were contaminated by As. Considering different sediment quality guidelines, it was observed that Cr, Ni, and As posed occasional adverse biological effects on marine organisms. Multivariate statistical approaches were applied to elucidate the origin and transport behavior of the studied metal(loid)s in the mangrove ecosystem which suggested that sources of metal(loid) pollution were both anthropogenic and geogenic. The results from this study should improve the knowledge of metal contamination and ecological risk to biota to develop new strategies and enlarge management practices to save sensitive mangrove ecosystems.