bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hsa_circ_0136666 mediates the antitumor effect of curcumin in colorectal carcinoma by regulating CXCL1 via miR-1301-3p
Authors: Chen Shi , Li Wei , Ning Chen-Gong , Wang Feng , Wang Li-Xing , Liao Chen , Sun Feng 
Published: December 2023

BACKGROUND
This study investigate the anti-tumor effect of curcumin and whether its mediated by hsa_circ_0136666 through miR-1301-3p/CXCL1 in colorectal carcinoma (CRC). Through multiple experiments, we have drawn the conclusion that curcumin inhibited CRC development through the hsa_circ_0136666/miR-1301-3p/CXCL1 axis, hinting at a novel treatment option for curcumin to prevent CRC development.
AIM
To determine whether hsa_circ_0136666 involvement in curcumin-triggered CRC progression was mediated by sponging miR-1301-3p.
METHODS
Cell counting kit-8, colony-forming cell, 5-ethynyl-2’-deoxyuridine, and flow cytometry assays were carried out to determine cell proliferation, apoptosis, and cell cycle progression. Real-time quantitative polymerase chain reaction quantified hsa_circ_0136666, miR-1301-3p, and chemokine (C-X-C motif) ligand 1 (CXCL1 ), and western blot analysis determined CXCL1 , B-cell lymphoma-2 (Bcl-2), and Bcl-2 related X protein (Bax) protein levels. CircBank or starbase software was first used for the prediction of miR-1301-3p binding with hsa_circ_0136666 and CXCL1 , followed by RNA pull-down, RNA immunoprecipitation, and dual-luciferase reporter assay validation. In vivo experiments were implemented in a murine xenograft model.
RESULTS
Curcumin blocked CRC cell proliferation but boosted apoptosis. Moreover, elevated hsa_circ_0136666 Levels were observed in CRC cells, which were reduced by curcumin. In vitro , hsa_circ_0136666 overexpression abolished the antitumor activity of CRC cells. Mechanical analysis revealed the ability of hsa_circ_0136666 to sponge miR-1301-3p to modulate CXCL1 levels.
CONCLUSION
Curcumin inhibited CRC development through the hsa_circ_0136666/miR-1301-3p/CXCL1 axis, hinting at a novel treatment option for curcumin to prevent CRC development.
Evaluating the causal relationship between human blood metabolites and gastroesophageal reflux disease
Authors: Hu Jia-Yan , Lv Mi , Zhang Kun-Li , Qiao Xi-Yun , Wang Yu-Xi , Wang Feng-Yun 
Published: December 2023

BACKGROUND
Gastroesophageal reflux disease (GERD) affects approximately 13% of the global population. However, the pathogenesis of GERD has not been fully elucidated. The development of metabolomics as a branch of systems biology in recent years has opened up new avenues for the investigation of disease processes. As a powerful statistical tool, Mendelian randomization (MR) is widely used to explore the causal relationship between exposure and outcome.
AIM
To analyze of the relationship between 486 blood metabolites and GERD.
METHODS
Two-sample MR analysis was used to assess the causal relationship between blood metabolites and GERD. A genome-wide association study (GWAS) of 486 metabolites was the exposure, and two different GWAS datasets of GERD were used as endpoints for the base analysis and replication and meta-analysis. Bonferroni correction is used to determine causal correlation features (P < 1.03 × 10-4). The results were subjected to sensitivity analysis to assess heterogeneity and pleiotropy. Using the MR Steiger filtration method to detect whether there is a reverse causal relationship between metabolites and GERD. In addition, metabolic pathway analysis was conducted using the online database based MetaboAnalyst 5.0 software.
RESULTS
In MR analysis, four blood metabolites are negatively correlated with GERD: Levulinate (4-oxovalerate), stearate (18:0), adrenate (22:4n6) and p-acetamidophenylglucuronide. However, we also found a positive correlation between four blood metabolites and GERD: Kynurenine, 1-linoleoylglycerophosphoethanolamine, butyrylcarnitine and guanosine. And bonferroni correction showed that butyrylcarnitine (odd ratio 1.10, 95% confidence interval: 1.05-1.16, P = 7.71 × 10-5) was the most reliable causal metabolite. In addition, one significant pathways, the “glycerophospholipid metabolism” pathway, can be involved in the pathogenesis of GERD.
CONCLUSION
Our study found through the integration of genomics and metabolomics that butyrylcarnitine may be a potential biomarker for GERD, which will help further elucidate the pathogenesis of GERD and better guide its treatment. At the same time, this also contributes to early screening and prevention of GERD. However, the results of this study require further confirmation from both basic and clinical real-world studies.
Management of the Electronic Health Record Inbox: Results From a National Survey of Internal Medicine Program Directors
Authors: Vaa Stelling Brianna , Halvorsen Andrew J. , Dupras Denise , Kearns Lisa , Kisielewski Michael , Martin Shannon K. , Uthlaut Brian , Leasure Emily 
Published: December 2023

Background Internal medicine (IM) resident physicians spend a considerable amount of time managing their inbox as part of their longitudinal continuity clinic experience. There are no standardized guidelines for how programs should train, monitor, or supervise residents in this type of patient care.
Objective To understand how IM residency programs educate, monitor, and supervise resident electronic health record (EHR) inbox management as part of their longitudinal continuity clinic and determine whether patient safety events have occurred due to EHR inbox-related patient care decisions made by unsupervised resident physicians.
Methods In August 2021, 439 program directors at accredited US IM residency programs who were members of the Association of Program Directors in Internal Medicine (APDIM) were asked 12 questions developed by the study authors and APDIM survey committee members regarding resident EHR inbox management as part of the annual APDIM survey.
Results Two hundred and sixty-seven (61%) PDs responded. The majority (224 of 267, 84%) of programs provided guidelines for expected message response times; less than half (115, 43%) monitored timeliness metrics. Only half (135; 51%) of programs required faculty supervision of inbox messages for all residents; 28% (76) did not require supervision for any residents. Twenty-one percent of PDs (56) reported awareness of a patient safety event occurring due to an unsupervised resident inbox-related patient care decision.
Conclusions Substantial variability exists in how IM residency programs train, monitor, supervise, and provide coverage for resident inbox work. Program directors are aware of patient safety events resulting from unsupervised resident inbox management.
Impact of Preference Signals on Interview Selection Across Multiple Residency Specialties and Programs
Authors: Rosenblatt Adena E. , LaFemina Jennifer , Sood Lonika , Choi Jennifer , Serfin Jennifer , Naemi Bobby , Dunleavy Dana 
Published: December 2023

Background Program signaling is an innovation that allows applicants to express interest in specific programs while providing programs the opportunity to review genuinely interested applicants during the interview selection process.
Objective To examine the influence of program signaling on “selected to interview” status across specialties in the 2022 Electronic Residency Application Service (ERAS) application cycle.
Methods Dermatology, general surgery-categorical (GS), and internal medicine-categorical (IM-C) programs that participated in the signaling section of the 2022 supplemental ERAS application (SuppApp) were included. Applicant signal data was collected from SuppApp, applicant self-reported characteristics collected from the MyERAS Application for Residency Applicants, and 2020 program characteristics collected from the 2020 GME Track Survey. Applicant probability of being selected for interview was analyzed using logistic regression, determined by the selected to interview status in the ERAS Program Director’s WorkStation.
Results Dermatology had a 62% participation rate (73 of 117 programs), GS a 75% participation rate (174 of 232 programs), and IM-C an 86% participation rate (309 of 361 programs). In all 3 specialties examined, on average, signaling increased the likelihood of being selected to interview compared to applicants who did not signal. This finding held across gender and underrepresented in medicine (UIM) groups in all 3 specialties, across applicant types (MDs, DOs, international medical graduates) for GS and IM-C, and after controlling for United States Medical Licensing Examination Step 1 scores.
Conclusions Although there was variability by program, signaling increased likelihood of being selected for interview without negatively affecting any specific gender or UIM group.
A Successful Management of Ankylosing Spondylitis with Avascular Necrosis Through Ayurveda
Authors: Shreeshailaswamy S. Kanvimath  , L. Mahadevan  , Ishwarayya S. Mathapati  
Published: December 2023

This case report aimed to reveal an Ayurvedic approach to a atypical case of Ankylosing Spondylitis with bilateral avascular necrosis of femoral head. Ankylosing Spondylitis (AS) is a condition posing major challenge to health care system.
A 29-year-old male subject was diagnosed with ankylosing spondylitis and avascular necrosis of bilateral femur head. By the clinical presentation and thorough Ayurvedic examinations of the subject the case was diagnosed as Gambheera Vatarakta with Asthisoushirya. The case was successfully managed with both Shodhana and Shamana Upacharas according to Ayurveda i.e., for Asthisoushirya, Khara Abhishyandi Snigdha Gunayukta Dravya Prayogam, Asthi Poshakam, Ghrita or Ksheera processed with Tikta Rasa and Vataraktahara Chikitsa, Ama Pachana, Rakta Prasadana, Sneha Virechana and Basti for Gambheera Vatarakta was followed and significant prognosis was achieved.
The Impact of COVID-19 on the Congolese Financial System : An empirical Investigation
Authors: Pinshi Christian P. , Tabash Mosab I. 
Published: December 2023

The COVID-19 pass-through on the financial system moves at supersonic speed, undermining financial stability with a contraction of claims on the private sector, withdrawing deposits, and tightening the fiscal circumstances . The primary goal of this research is to investigate the unprecedented influenceof COVID-19 on the Congolese financial system. An autoregressive Vector Bayesian model is used to test the connection . The data utilized is a monthly series from December 2013 to October 2020. The results reveal that the COVID-19 pandemic has varying degrees of negative impact on the Congolese financial system. The Congolese government should immediately ado pt macroeconomic and financial policies by boosting and injecting liquidity into the banking sector to mitigate the negative consequences. At the same time, the expansion of Fintechs on the one hand and the expansion of cyberattacks on the other would enhance the financial system landscape . To maximize the digitization of the financial systems and enhance the effectiveness of cybersecurity, financial institutions should implement intelligent policies and invest in research. This study is the first to be done in Congo to the authors' best knowledge and serves as a battery for further research in Africa and the world.
Tokenized Indexed-Green Bonds: Funding the Decarbonisation of Ammonia Production
Authors: Charles Don 
Published: December 2023

This study seeks to investigate how distributed ledger technology can be applied to the green bond market. Second, this study examines how green bonds can finance the suck cost of decarbonizing the ammonia industry. Third, this study seeks to forecast the spot price of ammonia. This forecast is relevant since the bond’s coupon should be indexed and linked to the price of ammonia. The proposed tokenized indexed-green bond is a new idea that leverages the technologies of distributed ledgers, indexation, and green bonds. No study to current date has undertaken such research that integrates these technologies to fund the decarbonization of the ammonia industry. Data was collected on the spot price of ammonia from the Central Bank of Trinidad and Tobago online database at the monthly frequency over the January 1991 to June 2023 period. The applied forecasting methodology was a hybrid framework combining Particle Swarm Optimization and Support Vector Regression. This study found that an out-of-sample forecast for ammonia prices would be US$438.89/ton in the 1st quarter, US$289.99/ton by the 2nd quarter, US$448.30/ton by the 3rd quarter, and US$331.57/ton by the 4th quarter. The decarbonization of the ammonia industry is technically possible. Economically, it would involve leveraging several technologies such as green bond financing, tokenization, and indexation.

Received: 26 May 2023 | Revised: 1 September 2023 | Accepted: 3 December 2023

Conflicts of Interest
The author declares that he has no conflicts of interest to this work.

Data Availability Statement
Data available on request from the corresponding author upon reasonable request.

Author Contribution Statement
Don Charles: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, resources, data curation, Writing - original draft, Writing - review & editing, Visualization, Supervision, Project administration.
Penerapan Sistem Informasi Pelayanan Publik Pada Fitur LAKSA Di Kota Tangerang
Authors: Amelia Risma , Cahaya Ningrum Agni , Maharani Setyadana Aldisya , Fitri Kamila Diah , Arif Kurniawan Irvan 
Published: December 2023

Perkembangan teknologi informasi kini membawa perubahan signifikan. Manusia menciptakan teknologi dengan motivasi dan dorongan agar hidup menjadi lebih baik. Manusia membuat teknologi dan menciptakan alat-alat untuk mendukung perkembangan informasi. Perkembangan tersebut harus diimbangi dengan hadirnya inovasi sistem informasi pelayanan publik berbasis aplikasi yang bermanfaat bagi pemerintah dan masyarakat. Penerapan sistem informasi mutlak ada di semua organisasi. Karena sistem informasi bukanlah organisasi atau lembaga itu sendiri, melainkan membantu pelaksanaan proses kerja agar dapat berfungsi dengan baik sesuai dengan yang diharapkan. Informasi yang tersedia bagi masyarakat membutuhkan informasi yang cepat dan tepat waktu, termasuk penerapan informasi pelayanan publik di Kota Tangerang. Pemerintah Kota Tangerang telah meluncurkan aplikasi berbasis TIK bernama Tangerang Live yang didalamnya terdapat fitur LAKSA. LAKSA merupakan ruang virtual yang disediakan Pemerintah Kota Tangerang dalam menjawab tantangan pelayanan prima kepada masyarakat Kota Tangerang di era cyber, khususnya dalam hal penampung saran maupun pengaduan terkait permasalahan yang ada di wilayah Kota Tangerang. Penelitian ini bertujuan untuk mengetahui bagaimana upaya pemerintah Kota Tangerang dalam mensosialisasikan penerapan sistem informasi dalam aplikasi pada fitur laksa. Penelitian ini menggunakan metode penelitian deskriptif kualitatif dengan pendekatan induktif. Teknik pengumpulan data yang digunakan yaitu wawancara. Teknik analisis data yang digunakan meliputi reduksi data, penyajian data dan penarikan kesimpukan. Penelitian ini menggunakan 5 dimensi teori data driven decision making capability yang dikemukakan oleh Lian Jia, Lagu Jiahe dan Dianne Hall (2015).
Scouting for Girls
Authors: Proctor Tammy M. 
Published: December 2023

This volume examines scouting—the largest voluntary movement for girls—in its first century of existence, seeking to understand how the organization has lasted and how it has changed.
Scouting for Girls: A Century of Girl Guides and Girl Scouts is the first global history of Girl Scouting and Guiding that addresses the successes and pitfalls of the 100-year-old organization from its beginning in Great Britain through its international expansion. Since 1910, millions of girls worldwide have been exposed to Scouting. While much has changed since 1910, the core values of Scouting/Guiding are still recognizable in today's programs, namely the empowerment of girls through adventure, character-building, home skills, outdoor pursuits, and active learning. But has Scouting's very willingness to change with the times undermined its original ideologies and fundamentally changed the movement?
As Girl Scouts and Guides move into their second century, their challenge will be to remain true to their founding values while remaking themselves on a regular basis. Given the changing nature of today's societies and the serious problems girls face on a daily basis, Girl Guides and Girl Scouts will need to be true to their motto, "Be Prepared," in order to march forward successfully into the future.
UMA ANÁLISE DOS CRITÉRIOS LEGAIS DE RESPONSABILIZAÇÃO CIVIL DO FILHO EM CASO ABANDONO AFETIVO INVERSO
Authors: Nunes Ana Paula Bastos 
Published: December 2023

O presente artigo tem por objetivo uma análise acerca do abandono afetivo dos idosos. Tema é atual e relevante para a ciência e que merece atenção especial no âmbito jurídico, uma vez que as consequências que a falta de cuidado com a pessoa idosa, seja ela material ou afetivo, material pela omissão de dar provimento na subsistência do Idoso, e afetivo pela ausência de afeto do filho com a pessoa idosa, e uma situação que ocasiona dor e sofrimento aos envolvidos, principalmente para a pessoa idosa que muitas das vezes está em situação de vulnerabilidade. A Constituição Federal de 1988, em seu artigo 229 diz: Os pais têm o poder de assistir, criar e educar os filhos menores, e os filhos maiores têm o dever de ajudar e amparar os pais na velhice, carência ou enfermidade. E o Estatuto do Idoso reafirma a obrigação da família, da comunidade, da sociedade e do Poder público, em assegurar ao idoso o princípio da dignidade humana. Portanto, a análise será geral do instituto dos alimentos, seu conceito, sua natureza, sua finalidade e a reciprocidade na obrigação alimentar, tendo como base diversos autores. Visando despertar a obrigação alimentar e afetiva dos filhos para com os pais quando não pode por si só manter seu próprio sustento.
Sobre tres poemas de Luis Alberto de Cuenca: entre la reescritura y la variación
Authors: Suárez Martínez Luis Miguel 
Published: December 2023

El poema “Ἔρως ἀνίκατε μάχαν”, aparecido en la antología Espejo del amor y de la muerte (1971), no fue luego incluido por Luis Alberto de Cuenca en Elsinore. Para explicar esa exclusión puede resultar pertinente analizar sus paralelismos temáticos y formales con otros dos poemas de ese libro: “Desitjada mort” y “Love’s Labour’s lost”. El análisis, que se extiende al plano léxico, revela unas conexiones tan estrechas entre los tres que permiten considerarlos como variaciones sobre un mismo motivo —a modo de tríptico elegiaco inspirado por el recuerdo de la amada muerta— e incluso, en el caso de los dos primeros, como versiones sucesivas del mismo poema.
The concept of parent involvement. Some theoretical and empirical considerations
Authors: Bakker Joep , Denessen Eddie 
Published: December 2023

This paper focuses on some conceptual and methodological problems inherent in many empirical studies on parental involvement. On the basis of twelve selected studies in which quantitative measures for parent involvement have been used, we discuss the reasons for the diversity of empirical outcomes, partly due to the complexity and multi-dimensionality of the concept, but also due to the variety of operationalizations as well as methods that have been applied to assess parents’ levels of involvement. In particular, empirical evidence of involvement obtained with questionnaires should be considered as doubtful because of the biases in ratings, whereas the use of multiple informants, as suggested in the literature, does not seem satisfactory to overcome this problem. We suggest the use more qualitative methods for measuring parent involvement, for example by interviewing parents in depth about their own accounts for their behaviours. This seems also the best guarantee to detect the more hidden features of their involvement in their children’s education.
Menjumpai Allah dalam Keseharian
Authors: Aritonang Josua 
Published: December 2023

Dalam perjalanan iman orang percaya, sebagian individu memilih untuk mengedepankan pengalaman dengan Tuhan yang Mahatinggi melalui peristiwa-peristiwa yang menakjubkan (dikotomis). Mereka cenderung meyakini bahwa hanya melalui peristiwa yang tidak umum, Tuhan bisa dialami. Melalui pandangan ini, terlihat seolah-olah Tuhan tidak dapat ditemui dalam aktivitas-aktivitas sehari-hari seperti bekerja, bertemu dengan sesama, makan, dan lain sebagainya yang dilakukan setiap hari. Dalam konteks permasalahan ini, peneliti berupaya memberikan solusi dengan tujuan memperluas pemahaman tentang pengalaman dan perjumpaan iman dengan Tuhan. Adapun metode yang digunakan dalam penelitian ini adalah kualitatif, yaitu studi kepustakaan. Hasil dari penelitian ini menunjukkan bahwa spiritualitas sehari-hari muncul sebagai sebuah model spiritualitas yang menawarkan solusi bagi permasalahan pemikiran dikotomis tentang pengalaman iman dengan Tuhan. Spiritualitas sehari-hari memahami bahwa Tuhan dapat dialami dan hadir lewat kejadian-kejadian sederhana dari hari ke hari ketika menjalani aktivitas harian. Selain itu, penelitian ini juga menyatakan bahwa teologi penciptaan dan inkarnasi dapat menjadi landasan yang kokoh bagi spiritualitas sehari-hari. Kedua teologi ini relevan dengan spiritualitas sehari-hari karena sama-sama menekankan pentingnya menjalani aktivitas keseharian dengan setia, melihat kebaikan dalam setiap ciptaan, dan meyakini bahwa ciptaan itu sendiri menceritakan tentang Sang Pencipta.
Juristen moeten kennis hebben van doctrinair onderzoek en wetenschapsfilosofie
Authors: Arnoldussen Tobias 
Published: December 2023

Juristen moeten kennis hebben van doctrinair onderzoek en wetenschapsfilosofie
In answer to Gitta Veldt’s call to educate law students in social scientific methodologies, this essay makes the argument that we should in fact strengthen the knowledge of legal doctrinal methodology. Lawyers should be more aware of the value of their own scientific methodology, because that unique quality makes them interesting as researchers in collaborative interdisciplinary teams. They should also be aware though of the possibilities and limitations of their own methodologies as well as those of the empirical sciences. A thorough education in the philosophy of science should give lawyers the skills to decide whether the legal question can be answered using doctrinal methodology or whether an expert in one of the empirical sciences should be consulted.
The Impact of the Covid-19 Pandemic on the Business Performance of Construction Industry Enterprises in Can Tho City
Authors: Tu Phan Anh , Toan Dinh Xuan , Hanh Nguyen Kim , Duyen Chau Thi Le , Huong Do Thuy 
Published: December 2023

Objective: This study is to investigate the influence of COVID-19 pandemic on the business performance of micro, small, and medium enterprises within the construction industry.

Methods: To evaluate the impact of the COVID-19 pandemic on the business performance of SMEs, the authors employ two linear regression models to analyze and identify factors influencing business performance and the change in business performance before and after the COVID-19 pandemic. The model aims to determine the effect of the COVID-19 pandemic on the business performance of SMEs in the construction industry in Can Tho city.

Results: Based on the dataset of 186 observations and the regression result shows that seven factors account for the variation in business performance of construction industry enterprises during the pandemic including disruptions in production, policies for capital support, scarcities in materials, and shortages in labor. The findings remained consistent after controlling other personal traits such as employee education, manager's educational and experience.

Conclusion: The majority of industrial and construction enterprises were confronted with greater barriers in business operations during the COVID-19 pandemic, therefore, this led to a decline in revenue and profit for these businesses. The implications of this study are expected to guide business leaders in adopting appropriate adaptive strategies to enhance their business performance.