bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracheal adenoid cystic carcinoma masquerading asthma: A case report
Authors: Kokturk Nurdan , Demircan Sedat , Kurul Cuneyt , Turktas Haluk 
Published: October 2004

Abstract
Background
Tracheal tumors are often misdiagnosed as asthma and are treated with inhaled steroids and bronchodilators without resolution.

Case Presentation
Here, a patient with tracheal adenoid cystic carcinoma who had been previously diagnosed with difficult asthma was reported. The possibility of the presence of localized airway obstruction was raised when the flow-volume curve suggesting fixed airway obstruction, was obtained.

Conclusion
The presenting case report emphasizes the fact that not all wheezes are asthma. It is critical to bear in mind that if a patient does not respond to appropriate anti-asthma therapy, localized obstructions should be ruled out before establishing the diagnosis of asthma.
Effects of lornoxicam on the physiology of severe sepsis
Authors: Memiş Dilek , Karamanlıoğlu Beyhan , Turan Alparslan , Koyuncu Onur , Pamukçu Zafer 
Published: October 2004

Abstract
Introduction
The purpose of the present study was to evaluate the effects of intravenous lornoxicam on haemodynamic and biochemical parameters, serum cytokine levels and patient outcomes in severe sepsis.

Methods
A total of 40 patients with severe sepsis were included, and were randomly assigned (20 per group) to receive either lornoxicam (8 mg administered intravenously every 12 hours for six doses) or placebo. For both groups the following were recorded: haemodynamic parameters (heart rate, mean arterial pressure), nasopharyngeal body temperature, arterial blood gas changes (pH, partial oxygen tension, partial carbon dioxide tension), plasma cytokine levels (IL-1β, IL-2 receptor, IL-6, IL-8, tumour necrosis factor-α), biochemical parameters (lactate, leucocytes, trombocytes, creatinine, total bilirubin, serum glutamate oxalate transaminase), length of stay in the intensive care unit, duration of mechanical ventilation and mortality. All measurements were obtained at baseline (before the start of the study) and at 24, 48 and 72 hours from the start of lornoxicam/placebo administration.

Results
No significant differences were found between the intravenous lornoxicam and placebo groups in major cytokines, duration of ventilation and length of intensive care unit stay, and inspired fractional oxygen/arterial oxygen tension ratio (P > 0.05).

Conclusion
In these patients with severe sepsis, we found intravenous lornoxicam to exert no effect on haemodynamic and biochemical parameters, cytokine levels, or patient outcomes. Because of the small number of patients included in the study and the short period of observation, these findings require confirmation by larger clinical trials of intravenous lornoxicam, administered in a dose titrated manner.
Spatial patterns of transcriptional activity in the chromosome of Escherichia coli
Authors: Jeong Kyeong Soo , Ahn Jaeyong , Khodursky Arkady B 
Published: October 2004

Abstract
Background
Although genes on the chromosome are organized in a fixed order, the spatial correlations in transcription have not been systematically evaluated. We used a combination of genomic and signal processing techniques to investigate the properties of transcription in the genome of Escherichia coli K12 as a function of the position of genes on the chromosome.

Results
Spectral analysis of transcriptional series revealed the existence of statistically significant patterns in the spatial series of transcriptional activity. These patterns could be classified into three categories: short-range, of up to 16 kilobases (kb); medium-range, over 100-125 kb; and long-range, over 600-800 kb. We show that the significant similarities in gene activities extend beyond the length of an operon and that local patterns of coexpression are dependent on DNA supercoiling. Unlike short-range patterns, the formation of medium and long-range transcriptional patterns does not strictly depend on the level of DNA supercoiling. The long-range patterns appear to correlate with the patterns of distribution of DNA gyrase on the bacterial chromosome.

Conclusions
Localization of structural components in the transcriptional signal revealed an asymmetry in the distribution of transcriptional patterns along the bacterial chromosome. The demonstration that spatial patterns of transcription could be modulated pharmacologically and genetically, along with the identification of molecular correlates of transcriptional patterns, offer for the first time strong evidence of physiologically determined higher-order organization of transcription in the bacterial chromosome.
Assembly and characterization of heterochromatin and euchromatin on human artificial chromosomes
Authors: Grimes Brenda R , Babcock Jennifer , Rudd M Katharine , Chadwick Brian , Willard Huntington F 
Published: October 2004

Abstract
Background
Human centromere regions are characterized by the presence of alpha-satellite DNA, replication late in S phase and a heterochromatic appearance. Recent models propose that the centromere is organized into conserved chromatin domains in which chromatin containing CenH3 (centromere-specific H3 variant) at the functional centromere (kinetochore) forms within regions of heterochromatin. To address these models, we assayed formation of heterochromatin and euchromatin on de novo human artificial chromosomes containing alpha-satellite DNA. We also examined the relationship between chromatin composition and replication timing of artificial chromosomes.

Results
Heterochromatin factors (histone H3 lysine 9 methylation and HP1α) were enriched on artificial chromosomes estimated to be larger than 3 Mb in size but depleted on those smaller than 3 Mb. All artificial chromosomes assembled markers of euchromatin (histone H3 lysine 4 methylation), which may partly reflect marker-gene expression. Replication timing studies revealed that the replication timing of artificial chromosomes was heterogeneous. Heterochromatin-depleted artificial chromosomes replicated in early S phase whereas heterochromatin-enriched artificial chromosomes replicated in mid to late S phase.

Conclusions
Centromere regions on human artificial chromosomes and host chromosomes have similar amounts of CenH3 but exhibit highly varying degrees of heterochromatin, suggesting that only a small amount of heterochromatin may be required for centromere function. The formation of euchromatin on all artificial chromosomes demonstrates that they can provide a chromosome context suitable for gene expression. The earlier replication of the heterochromatin-depleted artificial chromosomes suggests that replication late in S phase is not a requirement for centromere function.
Why Cancer Patients Enter Randomized Clinical Trials: Exploring the Factors That Influence Their Decision
Authors: Wright James R. , Whelan Timothy J. , Schiff Susan , Dubois Sacha , Crooks Dauna , Haines Patricia T. , DeRosa Diane , Roberts Robin S. , Gafni Amiram , Pritchard Kathleen , Levine Mark N. 
Published: October 2004

Purpose Few interventions have been designed and tested to improve recruitment to clinical trials in oncology. The multiple factors influencing patients' decisions have made the prioritization of specific interventions challenging. The present study was undertaken to identify the independent predictors of a cancer patient's decision to enter a randomized clinical trial. Methods A list of factors from the medical literature was augmented with a series of focus groups involving cancer patients, physicians, and clinical research associates (CRAs). A series of questionnaires was developed with items based on these factors and were administered concurrently to 189 cancer patients, their physicians, and CRAs following the patient's decision regarding trial entry. Forward logistic regression modeling was performed using the items significantly correlated (by univariate analysis) with the decision to enter a clinical trial. Results A number of items were significantly correlated with the patient's decision. In the multivariate logistic regression model, the patient's perception of personal benefit was the most important, with an odds ratio (OR) of 3.08 (P < .05). CRA-related items involving supportive aspects of the decision-making process were also important. These included whether the CRA helped with the decision (OR = 1.71; P < .05), and whether the decision was hard for the patient to make (OR = 0.52; P < .05). Conclusion Strategies that better address the potential benefits of trial entry may result in improved accrual. Interventions or aids that focus on the supportive aspects of the decision-making process while respecting the need for information and patient autonomy may also lead to meaningful improvements in accrual.
Early Deaths and Treatment-Related Mortality in Children Undergoing Therapy for Acute Myeloid Leukemia: Analysis of the Multicenter Clinical Trials AML-BFM 93 and AML-BFM 98
Authors: Creutzig Ursula , Zimmermann Martin , Reinhardt Dirk , Dworzak Michael , Stary Jan , Lehrnbecher Thomas 
Published: October 2004

Purpose The rates of early death (ED) and treatment-related mortality (TRM) are unacceptably high in children undergoing intensive chemotherapy for acute myeloid leukemia (AML). Better strategies of supportive care might help to improve overall survival in these children. Patients and Methods In a retrospective study, we analyzed incidence, clinical features, and risk factors for lethal complications of 901 children enrolled onto the multicenter trials Acute Myeloid Leukemia-Berlin-Frankfurt-Muenster (AML-BFM) 93 and AML-BFM 98. Results One hundred four patients (11.5%) enrolled onto the clinical trials AML-BFM 93 and AML-BFM 98 died shortly after diagnosis or as a result of treatment-related complications. Thirty-two patients (3.5%) died before (six patients) or during (26 patients) the first 14 days of treatment, mainly as a result of bleeding or leukostasis. Low performance status, hyperleukocytosis, and French-American-British type M5 were the main risk factors for a lethal event before day 15. After day 15, the predominant causes of death were complications caused by infections, particularly bacterial and fungal infections. The incidence of lethal infections was highest during induction therapy and decreased thereafter. When comparing both clinical trials, significantly fewer patients died within the first 6 weeks in AML-BFM 98 than in AML-BFM 93 (14 [3.5%] of 430 patients v 35 [7.4%] of 471 patients; P = .01). Conclusion To reduce the high incidence of ED and TRM in children with AML, early diagnosis and adequate treatment of complications are needed. Children with AML should be treated in specialized pediatric cancer centers only. Prophylactic and therapeutic regimens for better treatment management of bleeding disorders and infectious complications have to be assessed in future trials to ultimately improve overall survival in children with AML.
Effect of Pregnancy on Survival in Women With Cutaneous Malignant Melanoma
Authors: Lens Marko B. , Rosdahl Inger , Ahlbom Anders , Farahmand Bahman Y. , Synnerstad Ingrid , Boeryd Bernt , Newton Bishop Julia A. 
Published: October 2004

PurposeAn adverse influence of pregnancy on the risk of death in women with cutaneous melanoma was suggested historically by anecdotal reports. Previous studies included small numbers of women observed for short periods.MethodsUsing data from the Swedish National and Regional Registries, we performed a retrospective cohort study of all Swedish women who were diagnosed with cutaneous melanoma during their reproductive period, from January 1, 1958, to December 31, 1999. The relationship between pregnancy status at the diagnosis of melanoma and overall survival was examined in multivariable proportional-hazards models.ResultsThe cohort comprised 185 women (3.3%) diagnosed with melanoma during pregnancy and 5,348 (96.7%) women of the same childbearing age diagnosed with melanoma while not pregnant. There was no statistically significant difference in overall survival between pregnant and nonpregnant groups (log-rank χ21[r] = 0.84, P = .361). Pregnancy status at the time of diagnosis of melanoma was not related to survival in a multivariable Cox model in the 2,101 women (hazard ratio for death in the pregnant group was 1.08; 95% CI, 0.60 to 1.93). In the multivariable analysis, pregnancy status after diagnosis of melanoma was not a significant predictor of survival (hazard ratio for death in women who had pregnancy subsequent to the diagnosis of melanoma was 0.58; 95% CI, 0.32 to 1.05).ConclusionThe survival of pregnant women with melanoma is not worse than the survival of nonpregnant women with melanoma. Pregnancy subsequent to the diagnosis of primary melanoma was not associated with an increased risk of death.
Quality of Life of Postmenopausal Women in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial
Authors: Fallowfield Lesley , Cella David , Cuzick Jack , Francis Stephen , Locker Gershon , Howell Anthony 
Published: October 2004

Purpose To determine the quality of life (QoL) of women participating in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial during the first 2 years of treatment. Patients and Methods A total of 1,021 women were enrolled onto the QoL subprotocol. All had completed primary treatment (surgery ± radiotherapy ± chemotherapy) and were to receive 5 years of adjuvant treatment with anastrozole (n = 335), tamoxifen (n = 347), or a combination (n = 339) of both. Patients completed the Functional Assessment of Cancer Therapy-Breast (FACT–B) plus endocrine subscale (ES) at baseline and 3, 6, 12, 18, and 24 months, or until disease recurrence. The primary end point was the FACT–B Trial Outcome Index (TOI). The secondary end point was the ES total score. Analyses of individual endocrine symptoms were also explored. Results Questionnaire completion approximated 85% of assessments available for analysis. Overall QoL for all groups improved from baseline during the 2-year period. There were no significant differences in TOI or ES scores across treatment groups. Endocrine symptoms increased between baseline and 3 months for all groups and stabilized thereafter. There were some small differences in side effect profiles. Compared with patients receiving tamoxifen only, patients receiving anastrozole only reported significantly fewer cold sweats and vaginal discharge, yet more vaginal dryness, painful intercourse, and loss of sexual interest. Conclusion Two years of treatment with anastrozole, tamoxifen, or the combination had a similar overall QoL impact, showing gradual improvement over time. Endocrine-related symptoms for all three arms worsened initially and recovered partially during 2 years. The different symptoms experienced may assist in decision making about treatment and supportive care needs.
Phase II Study of Fenretinide (NSC 374551) in Adults With Recurrent Malignant Gliomas: A North American Brain Tumor Consortium Study
Authors: Puduvalli Vinay K. , Yung W.K. Alfred , Hess Kenneth R. , Kuhn John G. , Groves Morris D. , Levin Victor A. , Zwiebel James , Chang Susan M. , Cloughesy Timothy F. , Junck Larry , Wen Patrick , Lieberman Frank , Conrad Charles A. , Gilbert Mark R. , Meyers Christina A. , Liu Vivien , Mehta Minesh P. , Nicholas M. Kelly , Prados Michael 
Published: October 2004

PurposeFenretinide induces apoptosis in malignant gliomas in vitro. This two-stage phase II trial was conducted to determine the efficacy of fenretinide in adults with recurrent malignant gliomas.Patients and MethodsTwenty-two patients with anaplastic gliomas (AG) and 23 patients with glioblastoma (GBM) whose tumors had recurred after radiotherapy and no more than two chemotherapy regimens were enrolled. Fenretinide was given orally on days 1 to 7 and 22 to 28 in 6-week cycles in doses of 600 or 900 mg/m2bid.ResultsSix of 21 (29%) patients in the AG arm and two of 23 (9%) patients in the GBM arm had stable disease at 6 months. One patient with AG treated at 900 mg/m2bid dosage had a partial radiologic response. Median progression-free survival (PFS) was 6 weeks for the AG arm and 6 weeks for the GBM arm. PFS at 6 months was 10% for the AG arm and 0% for the GBM arm. Grade 1 or 2 fatigue, dryness of skin, anemia, and hypoalbuminemia were the most frequent toxicities reported. The trial was closed after the first stage because of the inadequate activity at the fenretinide doses used. The first-administration mean plasma Cmaxfor fenretinide was 832 ± 360 ng/mL at the 600 mg/m2bid dosage and 1,213 ± 261 ng/mL at the 900 mg/m2bid dosage.ConclusionFenretinide was inactive against recurrent malignant gliomas at the dosage used in this trial. However, additional studies using higher doses of the agent are warranted based on the tolerability of the agent and the potential for activity of a higher fenretinide dosage, as suggested in this trial.
Cancer Consultation Preparation Package: Changing Patients but Not Physicians Is Not Enough
Authors: Butow Phyllis , Devine Rhonda , Boyer Michael , Pendlebury Susan , Jackson Michael , Tattersall Martin H.N. 
Published: October 2004

Purpose This study evaluated a cancer consultation preparation package (CCPP) designed to facilitate patient involvement in the oncology consultation. Patients and Methods A total of 164 cancer patients (67% response rate) were randomly assigned to receive the CCPP or a control booklet at least 48 hours before their first oncology appointment. The CCPP included a question prompt sheet, booklets on clinical decision making and patient rights, and an introduction to the clinic. The control booklet contained only the introduction to the clinic. Physicians were blinded to which intervention patients received. Patients completed questionnaires immediately after the consultation and 1 month later. Consultations were audiotaped, transcribed verbatim, and coded. Results All but one patient read the information. Before the consultation, intervention patients were significantly more anxious than were controls (mean, 42 v 38; P = .04); however anxiety was equivalent at follow-up. The CCPP was reported as being significantly more useful to family members than the control booklet (P = .004). Patients receiving the intervention asked significantly more questions (11 v seven questions; P = .005), tended to interrupt the physician more (1.01 v 0.71 interruptions; P = .08), and challenged information significantly more often (twice v once; P = .05). Patients receiving the CCPP were less likely to achieve their preferred decision making style (22%) than were controls (35%; P = .06). Conclusion This CCPP influences patients' consultation behavior and does not increase anxiety in the long-term. However, this intervention, without physician endorsement, reduced the percentage of patients whose preferred involvement in decision making was achieved.
Where Infants Look Determines How They See: Eye Movements and Object Perception Performance in 3‐Month‐Olds
Authors: Johnson Scott P. , Slemmer Jonathan A. , Amso Dima 
Published: October 2004

AbstractA fundamental question of perceptual development concerns how infants come to perceive partly hidden objects as unified across a spatial gap imposed by an occluder. Much is known about the time course of development of perceptual completion during the first several months after birth, as well as some of the visual information that supports unity perception in infants. The goal of this investigation was to examine the inputs to this process. We recorded eye movements in 3‐month‐old infants as they participated in a standard object unity task and found systematic differences in scanning patterns between those infants whose post‐habituation preferences were indicative of unity perception versus those infants who did not perceive unity. Perceivers, relative to nonperceivers, scanned more reliably in the vicinity of the visible rod parts and scanned more frequently across the range of rod motion. These results suggest that emerging object concepts are tied closely to available visual information in the environment, and the process of information pickup.
Developmental Changes in Visual Scanning of Dynamic Faces and Abstract Stimuli in Infants: A Longitudinal Study
Authors: Hunnius Sabine , Geuze Reint H. 
Published: October 2004

AbstractThe characteristics of scanning patterns between the ages of 6 and 26 weeks were investigated through repeated assessments of 10 infants. Eye movements were recorded using a corneal‐reflection system while the infants looked at 2 dynamic stimuli: the naturally moving face of their mother and an abstract stimulus. Results indicated that the way infants scanned these stimuli stabilized only after 18 weeks, which is slightly later than the ages reported in the literature on infants' scanning of static stimuli. This effect was especially prominent for the abstract stimulus. From the 14‐week session on, infants adapted their scanning behavior to the stimulus characteristics. When scanning the video of their mother's face, infants directed their gaze at the mouth and eye region most often. Even at the youngest age, there was no indication of an edge effect.
Advances in Relating Eye Movements and Cognition
Authors: Hayhoe Mary M. 
Published: October 2004

AbstractMeasurement of eye movements is a powerful tool for investigating perceptual and cognitive function in both infants and adults. Straightforwardly, eye movements provide a multifaceted measure of performance. For example, the location of fixations, their duration, time of occurrence, and accuracy all are potentially revealing and often allow stronger inferences than measures such as percentage correct or reaction time. Another advantage is that eye movements are an implicit measure of performance and do not necessarily involve conscious processes. Indeed, they are often a more revealing measure than conscious report (Hayhoe, Bensinger, & Ballard, 1998). Although the mere presence of gaze at a particular location in the visual field does not reveal the variety of brain computations that might be operating at that moment, the experimental context within which the fixation occurs often provides critical information that allows powerful inferences. The articles in this thematic collection are excellent examples of this.
Toddlers' Reactions to the Distress of Familiar Peers: The Importance of Context
Authors: Demetriou Helen , Hay Dale F. 
Published: October 2004

AbstractReactions to peers' distress were recorded for 52 toddlers (hosts), 18 to 36 months old, who were observed playing with familiar peers in their own homes during 2 sessions, 6 months apart. Four contextual factors were explored: the host's responsibility for the guest's distress, similarity between the toddler and the distressed peer, relative familiarity of the peer, and the toddler's experience with peers and siblings. Hosts responded more positively to distress they had caused than to distress they witnessed. Negative reactions were most likely to be shown when hosts themselves had caused the distress of a guest of the same sex. Hosts were less likely to respond either positively or negatively if they had known their guests all their lives. Toddlers who had older siblings were more likely than other hosts to respond negatively to guests' distress.