bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyphyllin VII Enhances the Sensitivity of Prostate Cancer Cells to Docetaxel by Promoting Mitochondrial Dysfunction and Inducing Ferroptosis
Authors: Chen Yun‐Yi , Hua Wen‐Xi , Huang Yu‐Hua , Ding Xiang 
Published: January 2025

ABSTRACTDocetaxel (DTX) is the preferred chemotherapeutic drug for prostate cancer (Pca), but the emergence of resistance has significantly reduced its efficacy. Polyphyllin VII (PPVII), a small molecule natural product derived from the traditional herb Paris polyphylla, has shown anticancer potential. This study aims to investigate the effects and mechanisms of PPVII combined with DTX in treating Pca. DTX‐sensitive DU‐145 cells and DTX‐resistant DU145/DTX cells were utilized for experiments in this study. Cell viability was assessed using MTT assays, while apoptosis, cell cycles, and ferroptosis were analyzed through flow cytometry and Western blot. Mitochondrial function was evaluated using immunofluorescence. Additionally, the expression of proteins related to the AMP‐activated protein kinase/mammalian target of the rapamycin/S6 kinase (AMPK/mTOR/S6K) signaling pathway was also examined to further investigate the underlying mechanisms. PPVII significantly enhanced the inhibitory effect of DTX, reduced cell viability (p < 0.05), and promoted apoptosis (p < 0.05) and cell cycle arrest (p < 0.05). Specifically, PPVII increased the sensitivity of Pca cells to DTX by inducing ferroptosis and affecting mitochondrial function. Notably, the activation of the AMPK/mTOR/S6K signaling pathway played a crucial role in this process. This study revealed the synergistic effects and potential mechanisms of PPVII combined with DTX in Pca cells, and provided a reference for effectively overcoming DTX resistance in the clinical treatment of Pca.
Improving Parent and Therapist Experiences of Codelivering Intensive Upper Limb Interventions for Children With Hemiplegia: A Qualitative Study Using the Theoretical Domains Framework
Authors: Massey Jill , Tsianakas Vicki , Gordon Anne , Robert Glenn 
Published: January 2025

ABSTRACTBackgroundPartnership working between parents and therapists is a key component of family‐centred care (FCC). Such partnerships in paediatric intervention delivery can help achieve required levels of dosage, intensity and embed interventions in the child's everyday activities. This study explores the experience and views of parents and therapists codelivering an intensive upper limb intervention programme for children with hemiplegia, to find ways to enhance successful partnership working.MethodsSemistructured interviews were conducted with 12 parents and 8 therapists (3 hospital‐based and 5 community‐based). To help make evidence‐based recommendations, data were analysed using inductive reflexive analysis and mapped to the Theoretical Domains Framework (TDF) of constructs that are common determinants of clinical behaviours or practices.ResultsFive major themes were identified as follows: (1) realities of accessing intensive intervention, (2) key components of intervention delivery, (3) role of goal setting, (4) importance of partnership and (5) impact of intervention delivery on parents. Our findings showed that overall parents valued involvement in the programme, acknowledging benefits and challenges, as well as aspects in which they needed further support. Hospital therapists identified various education and training needs to improve their capabilities to coach parents and to collaboratively set meaningful goals. Community therapists valued the opportunity to develop their skills in intensive intervention and were keen to see evidence‐based interventions offered in the community.ConclusionsIt is possible for parents, hospital therapists and community therapists to codeliver intensive upper limb intervention programmes to children with hemiplegia. However, it is important to create a flexible programme which clearly acknowledges the roles, skills and unique contributions of parents and therapists which is conducive to truly equal partnership working in appropriate settings.
‘Bone Health—Across a Woman's Lifespan’
Authors: Stokes Gabrielle , Herath Madhuni , Samad Navira , Trinh Anne , Milat Frances 
Published: January 2025

ABSTRACTDespite a high burden of osteoporosis and minimal trauma fractures worldwide, there is still a treatment gap in timely diagnosis and optimal treatment. There is also a lack of international consensus and guidelines on the management of bone fragility in premenopausal women. This review article provides an overview of the current understanding of factors impacting women's bone health across the adult lifespan, as well as dilemmas in the diagnosis, assessment and management of osteoporosis in premenopausal and postmenopausal women, premature ovarian insufficiency and bone health following breast cancer.
Intra‐articular corticosteroids: Systematic review of effects of multiple injections and different doses
Authors: Tokawa P. K. A. , Baccarin R. Y. A. , Zanotto G. M. 
Published: January 2025

SummaryBackgroundCorticosteroids are commonly used for intra‐articular (IA) treatment of osteoarthritis (OA); however, controversy exists regarding its use as a multiple‐injection treatment and for appropriate dosing.ObjectivesThis systematic review collected and critically appraised evidence regarding the effects of (1) multiple injections protocols for OA treatment in horses and humans; (2) different doses of corticosteroids for treating OA in horses and humans; (3) different doses of corticosteroids in challenged joint tissues/cells in vitro.Study designSystematic review.MethodsTitles published up to June 2022 generated by searches in PubMed, CAB and the Web of Science were screened using general inclusion criteria. Each question (multiple treatments; different doses in vivo and in vitro) had further inclusion requirements. The risk of bias was assessed according to the study design. Horses were the species of interest but human studies were also considered.ResultsOf 6417 titles generated by the systematic search, only nine met all inclusion criteria for question 1, one was included for question 2 and 11 for question 3. Most studies showed unclear/high risk of bias. Multiple‐injection protocols showed better symptom‐modifying changes at first injections with decreasing improvements over time or for shorter follow‐ups in both humans and horses. Disease‐modifying changes improved over shorter follow‐ups; however, at longer periods, negative effects were seen. Determining the dose effect of different doses of corticosteroids was challenging as only one in vivo study met the inclusion criteria. In vitro, lower doses appeared to be safer for articular tissues.Main limitationsLack of studies meeting inclusion criteria.ConclusionsNo benefits but drawbacks of multiple IA injections in the long term were found in this review. Results regarding the dose of corticosteroids in OA joints were poorly available in vivo and support the use of lower doses. In vitro, studies pointed out that lower doses might be safer for joint tissues.
Effects of Conservation Agriculture on Soil N2O Emissions and Crop Yield in Global Cereal Cropping Systems
Authors: Zhu Yuhao , Li Ziyang , Zhao Dan , Zhang Bowen , Zhu Bo , Yao Zhisheng , Kiese Ralf , Butterbach‐Bahl Klaus , Zhou Minghua 
Published: January 2025

ABSTRACTConservation agriculture, which involves minimal soil disturbance, permanent soil cover, and crop rotation, has been widely adopted as a sustainable agricultural practice globally. However, the effects of conservation agriculture practices on soil N2O emissions and crop yield vary based on geography, management methods, and the duration of implementation, which has hindered its widespread scientific application. In this study, we assessed the impacts of no‐tillage (NT), both individually and in combination with other conservation agriculture principles, on soil N2O emissions and crop yields worldwide, based on 1270 observations from 86 peer‐reviewed articles. Our results showed that conservation agriculture practices significantly increased crop yield by 9.1% while significantly reducing soil N2O emissions by 6.8% compared to conventional tillage (CT). These mitigation effects were even greater when NT was combined with other conservation agriculture principles, such as crop residue retention and crop rotation, leading to reductions in N2O emissions of over 15% and yield increases of more than 30%. Additionally, conservation agriculture was more effective at mitigating soil N2O emissions in dry climates compared to humid regions. Long‐term adoption of conservation agriculture practices was found to reduce soil N2O emissions by up to 26% without compromising crop yields. Smallholder farm in Central Asia, South Asia, and sub‐Saharan Africa appear particularly suitable for the adoption of conservation agriculture, whereas, in humid climates, high nitrogen (N) input management and silt‐clay loam soil should be applied with caution. Overall, conservation agriculture holds significant potential for mitigating soil N2O emissions while enhancing grain yields in cereal cropping systems.
Are Games Always Fun and Fair? A Comparison of Reactions to Different Game‐Based Assessments
Authors: Ohlms Marie Luise , Melchers Klaus G. 
Published: January 2025

ABSTRACTGame‐based assessment (GBA) has garnered attention in the personnel selection and assessment context owing to its postulated potential to improve applicant reactions. However, GBAs can differ considerably depending on their specific design. Therefore, we sought to determine whether test taker reactions to GBAs vary owing to the different manifestations that GBAs may take on, and to test takers' individual preferences for such assessments. In an experimental study, each of N = 147 participants was shown six different GBAs and asked to rate several applicant reaction variables concerning these assessments. We found that reactions to GBAs were not inherently positive even though GBAs were generally perceived as enjoyable. However, perceptions of fairness and organizational attractiveness varied considerably between GBAs. Participants' age and experience with video games were related to reactions but had less impact than the different GBAs. Our results suggest that a technology‐as‐designed approach, which considers GBAs as a combination of multiple components (e.g., game elements), is crucial in GBA research to provide generalizable results for theory and practice.
The SlWRKY42–SlMYC2 module synergistically enhances tomato saline–alkali tolerance by activating the jasmonic acid signaling and spermidine biosynthesis pathway
Authors: Liu Xiaoyan , Shang Chunyu , Duan Pengyu , Yang Jianyu , Wang Jianbin , Sui Dan , Chen Guo , Li Xiaojing , Li Guobin , Hu Songshen , Hu Xiaohui 
Published: January 2025

ABSTRACTTomato (Solanum lycopersicum) is an important crop but frequently experiences saline–alkali stress. Our previous studies have shown that exogenous spermidine (Spd) could significantly enhance the saline–alkali resistance of tomato seedlings, in which a high concentration of Spd and jasmonic acid (JA) exerted important roles. However, the mechanism of Spd and JA accumulation remains unclear. Herein, SlWRKY42, a Group II WRKY transcription factor, was identified in response to saline–alkali stress. Overexpression of SlWRKY42 improved tomato saline–alkali tolerance. Meanwhile, SlWRKY42 knockout mutants, exhibited an opposite phenotype. RNA‐sequencing data also indicated that SlWRKY42 regulated the expression of genes involved in JA signaling and Spd synthesis under saline–alkali stress. SlWRKY42 is directly bound to the promoters of SlSPDS2 and SlNHX4 to promote Spd accumulation and ionic balance, respectively. SlWRKY42 interacted with SlMYC2. Importantly, SlMYC2 is also bound to the promoter of SlSPDS2 to promote Spd accumulation and positively regulated saline–alkali tolerance. Furthermore, the interaction of SlMYC2 with SlWRKY42 boosted SlWRKY42's transcriptional activity on SlSPDS2, ultimately enhancing the tomato's saline–alkali tolerance. Overall, our findings indicated that SlWRKY42 and SlMYC2 promoted saline–alkali tolerance by the Spd biosynthesis pathway. Thus, this provides new insight into the mechanisms of plant saline–alkali tolerance responses triggered by polyamines (PAs).
Physical Aspects of Sexuality, Attachment, and Sexual Satisfaction
Authors: Busby Dean M. , Allen Chelsea Zollinger , Leavitt Chelom E. , Jensen Alexander C. 
Published: January 2025

ABSTRACTHealthy sexuality includes relational, emotional, and physical elements as noted in the sexual wholeness model. Genital acceptance (emotional comfort with reactions to genitalia) and physical sexual knowledge (knowledge of the physical aspects of sex) are two areas of physical relationships that may be associated with sexual satisfaction. Attachment is a factor that has been associated with sexual relationships and may be an intervening variable between the physical aspects of sex and sexual satisfaction. Data from a dyadic sample of 515 couples were analyzed. Structural equation modeling was used to estimate the direct and indirect actor and partner effects of physical sexual knowledge and genital acceptance on sexual satisfaction, working through mechanisms of anxious and avoidant attachment. Findings revealed that genital acceptance and physical sexual knowledge, particularly knowledge about the female body, were associated with lower levels of insecure attachment and greater satisfaction with sexual relationships.
Comparative Analysis of 4NQO‐ and Ethanol‐Induced Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma in Male and Female Mice: Association With Peripheral Blood Inflammatory Markers
Authors: Costa Anaíra Ribeiro Guedes Fonseca , de Oliveira Santos Débora , Pereira Isabella Moura , Rosa Rafael Borges , de Castro Emilene Ferreira , de Jesus Ianca Daniele Oliveira , Silva Mariana Daiani Costa , Cardoso Sérgio Vitorino , Loyola Adriano Mota , de Faria Paulo Rogério 
Published: January 2025

ABSTRACTBackgroundConsidering that peripheral blood biomarkers are prognostic predictors for several human tumors, this study aimed to comparatively analyze the association of hematological alterations with the incidence of epithelial dysplasia (ED) and oral squamous cell carcinoma (OSCC) in male and female mice treated with 4‐nitroquinoline‐N‐oxide (4NQO) and ethanol (EtOH).Methods120 C57Bl/6J mice (60 males and 60 females) were allocated to four groups (n = 15). They were treated firstly either with 5 mg/mL propylene glycol (PPG) or 100 μg/mL 4NQO in the drinking water for 10 weeks, followed by sterilized water (H2O) or 8% EtOH (v/v) for 15 weeks, as follows: PPG/H2O, PPG/EtOH, 4NQO/H2O, and 4NQO/EtOH (CEUA‐UFU, #020/21). After killing, tongues were collected for histopathological analysis of ED and OSCC. Blood samples were processed for complete blood count and calculation of neutrophil‐to‐lymphocyte ratio (NLR) and systemic immune‐inflammation index (SII).ResultsThe incidence of OSCC in females from the 4NQO/EtOH group (60%) was lower when compared to males (93%). Neutrophils, NLR, and SII increased from control animals (PPG/H2O and PPG/EtOH) to ED and OSCC‐bearing male and female mice (4NQO/H2O and 4NQO/EtOH), while lymphocytes decreased. Females from the 4NQO/H2O group with ED also had higher neutrophils, NRL, and SII values than females with normal tongues.ConclusionThe low incidence of 4NQO‐ and ethanol‐induced OSCC in females indicates that the sex bias in OSCC may not be associated with extrinsic risk factors alone. Neutrophil and lymphocyte counts, NRL, and SII were significantly altered during multistep carcinogenesis and thus could be explored as biomarkers for ED and OSCC development.
A Qualitative Study on Nurses' Caring Experiences With Individuals With Kidney Failure Receiving Haemodialysis
Authors: Boateng Edward Appiah , Bodua‐Mango Bernice , Kyei‐Dompim Joana , Amooba Philemon Adoliwine 
Published: January 2025

ABSTRACTBackgroundKidney failure is a major health issue globally, particularly in Ghana and other low‐ and middle‐income countries. Nurses are centrally involved in the direct care and technical operations of managing individuals with kidney failure, and they have first‐hand exposure to the complexities of kidney failure management, including haemodialysis within resource‐constrained settings.ObjectiveThis study explored the experiences of nurses who provide care to individuals with kidney failure receiving haemodialysis in Ghana.MethodsA qualitative exploratory descriptive approach was used. Sixteen participants were selected using purposive sampling. Data was collected through in‐depth interviews and analysed using reflexive thematic analysis.ResultsFour main themes that reflect the experiences of nurses caring for individuals with kidney failure receiving haemodialysis in Ghana were identified, showing that nurses caring for these individuals consider their care as expensive, demanding, suboptimal and emotionally distressing for nurses.ConclusionThis study provides valuable insights that could enhance the understanding of the meaning and significance of caring for individuals receiving haemodialysis. Improving the haemodialysis caring experiences of nurses in Ghana requires addressing issues related to cost, emotional stress and workload of nurses, and resource availability. Changes to the healthcare system are needed to enhance the experience of patients and medical professionals involved in haemodialysis.
Key factors associated with oral health services at Federally Qualified Health Centers
Authors: Pang Jinman , Surdu Simona , Fernando Theekshana , Moore Jean 
Published: January 2025

AbstractObjectiveThis study aimed to investigate changes in oral health services from 2012 to 2021 and identify factors influencing the number of different types of services directly provided by all Federally Qualified Health Centers (FQHCs).MethodsData from the 2012–2021 Uniform Data System were analyzed using multilevel mixed‐effect negative binomial regression models. These models explored associations between oral health staffing, federal grant revenue, and state Medicaid dental policies for adults, and the number of different types of oral health services provided at FQHCs. Regressions were adjusted for FQHC and state characteristics, and survey year.ResultsFQHC visits for any oral health service increased significantly with each additional full‐time equivalent (FTE) in all types of oral health staffing, ranging between 0.8% and 13.7% (e.g., IRR = 1.137, 95% CI = 1.126–1.148 for preventive services by dental hygienists/therapists). Preventive dental visits increased significantly by 32% (IRR = 1.320, 95% CI = 1.028–1.694) for every 1% increase in the proportion of capital development grants to the total revenue. Although not statistically significant, FQHCs in states with extensive Medicaid dental coverage had a 2%–7% increase in all types of oral health services except emergency services compared to those in states with emergency‐only coverage.ConclusionsThis study found that increasing dental staffing, particularly of dental hygienists/therapists, enhances FQHCs' ability to provide preventive services. Capital development grants also positively influence preventive dental care delivery. Expanding Medicaid dental coverage may also increase service utilization, particularly among underserved groups, reducing oral health disparities.
Crowdsourcing for addressing grand challenges: Sponsor‐challenge fit, identified motivation, and the intention to submit
Authors: Garaus Christian , Garaus Marion , Wagner Udo 
Published: January 2025

AbstractDespite the growing interest in using crowdsourcing to address grand challenges such as climate change, the underlying mechanism that explains users' intention to submit ideas to such crowdsourcing initiatives of relevance for wider society is poorly understood. Building on the self‐determination theory, this article investigates different types of motivation and provides compelling theoretical and empirical evidence for the critical role of one motivation which is so far under‐researched, that of identified motivation (i.e., which is personally important and consciously valued), in triggering users' intention to submit. We further identify a new construct stimulating motivation—sponsor‐challenge fit—and reveal identified motivation as an underlying mechanism explaining the influence of sponsor‐challenge fit on the intention to submit to crowdsourcing initiatives addressing grand challenges. We demonstrate the importance of identified motivation compared to other types of motivation and explore two moderators (sponsor transparency and sponsor capability) in two scenario‐based experiments involving fictitious crowdsourcing initiatives. The first study demonstrates that increased sponsor transparency (i.e., open disclosure of submission guidelines and selection criteria) strengthens the effect of sponsor‐challenge fit on users' identified motivation and, consequently, their intention to submit. The second study reveals that sponsor capability (i.e., financial and operational ability to develop ideas further) can mitigate the negative effects of a low sponsor‐challenge fit, thereby enhancing identified motivation even when the fit is low. Our article contributes to the existing literature by highlighting the identified motivation's role in addressing grand challenges, clarifying the impact of the alignment between sponsor and challenge on engagement, and demonstrating how sponsor transparency benefits organizations with high fit while sponsor capability aids those with low fit.
Exploring the progress and trends of immunotherapy for type 1 diabetes: A comprehensive bibliometric analysis spanning nearly two decades
Authors: Jiang Yixin , Xu Zhou , Wu Yuting , Li Xinglei , Ling Jitao , Chen Yixuan , Zhu Zicheng , Yang Pingping , Liu Xiao , Zhang Deju , Liu Jianping , Yin Xiaoping , Zhang Jing , Yu Peng 
Published: January 2025

SummaryIntroductionImmunotherapy is a crucial treatment for type 1 diabetes (T1D), yet analyses focusing on research priorities and trends in this field are limited. Therefore, this study employs bibliometric methods to systematically explore the current research status of immunotherapy for T1D.MethodsBased on the Web of Science Core Collection Database, 1573 articles and review articles related to immunotherapy for T1D published from 2004 to 2023 were screened for bibliometric analysis. VOSviewer, CiteSpace, and R software were applied to comprehensively analyze the number of publications, journals, countries, authors, institutions, keywords, and references.ResultsIn the past two decades, the global annual publication rate has seen a significant increase of 238.24%. Almost 40% of all publications have appeared in the last 5 years, accounting for over 50% of total citations. Journals such as Diabetes, Journal of Autoimmunity and Frontiers in Immunology have exerted substantial influence. Collaboration across nations has been notably strong, with the United States leading the way. The University of Florida is the most productive institution. Terms like “nivolumab,” “ipilimumab,” “pembrolizumab,” and “immune checkpoint inhibitor(s)” gain considerable traction. The majority of research has clustered around themes such as immunomodulation, autoimmune diseases, immune checkpoint inhibitors, mesenchymal stem cells, and cell therapy. Precision medicine, immune checkpoint inhibitors, and nanotechnology are trending focal points in contemporary research.ConclusionThe outcomes of the study are instrumental in enabling scholars to comprehend the evolving trajectory of immunotherapeutic approaches for T1D and facilitate the swift recognition of emerging research pathways.