bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution and chemical diversity of the volatile compounds in Salvia species
Authors: Wang Feiyan , Huang Yanbo , Hou Zuoni , Chen Yue , Lou Ganggui , Qi Zhechen , Zhang Xiaodan , Dennis Mans , Zhang Lei , Wei Yukun , Yang Dongfeng 
Published: December 2023

AbstractIntroductionThe plant essential oils are composed of volatile compounds and have significant value in preventing and treating neurological diseases, anxiety, depression, among others. The genus Salvia has been shown to be an important medicinal resource, especially the aerial parts of genus Salvia, which are rich in volatile compounds; however, the chemical diversity and distribution patterns of volatile compounds in Salvia species are still unknown.ObjectiveThe work is performed to analyse the chemical diversity and distribution patterns of volatile compounds in genus Salvia.MethodsThe genomic single nucleotide polymorphisms (SNPs) combined with gas chromatography–mass spectrometry (GC–MS) were used to explore the evolution and chemical diversity of Salvia volatile compounds. Initially, the genetic relationship of genus Salvia was revealed by phylogenetic tree that was constructed based on SNPs. And then, GC–MS was applied to explore the chemical diversity of volatile compounds.ResultsThe results indicated that the volatile compounds were mainly monoterpenoids, sesquiterpenoids, and aliphatic compounds. The genomic SNPs divided species involved in this work into four branches. The volatile compounds in the first and second branches were mainly sesquiterpenoids and monoterpenoids, respectively. Species in the third branch contained more aliphatic compounds and sesquiterpenoids. And those in the fourth branch were also rich in monoterpenoids but had relatively simple chemical compositions.ConclusionThis study offered new insights into the phylogenetic relationships besides chemistry diversity and distribution pattern of volatile compounds of genus Salvia, providing theoretical guidance for the investigations and development of secondary metabolites.
Global quantitative proteomic analysis of aged mouse hippocampus
Authors: Huang He , van Waardenberg Ashley J. , Graham Mark E. , Anggono Victor , Widagdo Jocelyn 
Published: December 2023

AbstractUnderstanding the molecular changes associated with the aged brain forms the basis for developing potential strategies for slowing cognitive decline associated with normal aging. Focusing on the hippocampus, a critical brain region involved in learning and memory, we employed tandem mass tag methodology to investigate global proteomic changes that occur in advanced‐aged (20‐month) versus young (3‐month) C57BL/6 male mice. Our analysis revealed the upregulation of 236 proteins in the old hippocampal proteome, including those enriched within several age‐related processes, such as the adaptive immune response and molecular metabolic pathways, whereas downregulated proteins (88 in total) are mainly involved in axonogenesis and growth cone‐related processes. Categorizing proteins by cell‐type enrichment in the brain identified a general upregulation of proteins preferentially expressed in microglia, astrocytes, and oligodendrocytes. In contrast, proteins with neuron‐specific expression displayed an overall age‐related downregulation. By integrating our proteomic with our previously published transcriptomic data, we discovered a mild but significant positive correlation between mRNA and protein expression changes in the aged hippocampus. Therefore, this proteomic data is a valuable additional resource for further understanding age‐related molecular mechanisms.
Preliminary validation of the Cognitive Affective Mindfulness Scale–Revised in cancer populations
Authors: Snyder Stella , Secinti Ekin , Chinh Kelly , Wu Wei , Johns Shelley A. , Mosher Catherine E. 
Published: December 2023

AbstractObjectiveA brief, valid, and comprehensive measure of mindfulness is needed for cancer populations. This study examined the factor structure, internal consistency, construct validity, and measurement invariance of the 10‐item Cognitive Affective Mindfulness Scale‐Revised (CAMS‐R) in patients with cancer.MethodsPatients with breast, gastrointestinal, lung, or prostate cancer (N = 404, 50% stage IV cancer, 51% women) were recruited from academic and public clinics in Indianapolis, IN. Patients completed the CAMS‐R and other psychological measures at one time point. Confirmatory factor analysis (CFA) was used to examine the dimensionality of the CAMS‐R. Internal consistency and construct validity were also assessed. Measurement invariance was examined for gender, cancer type, and cancer stage.ResultsCFA showed that the original CAMS‐R structure with four first‐order factors (attention, present focus, awareness, and acceptance) and one second‐order factor (mindfulness) had a reasonable fit (RMSEA = 0.09, CFI = 0.95, SRMR = 0.04). Internal consistency was excellent (α = 0.90). The CAMS‐R total score showed significant positive associations with several subscales of a widely used mindfulness questionnaire and self‐compassion (rs = 0.61–0.66) and significant negative associations with anxiety, depressive symptoms, rumination, psychological inflexibility, and avoidant coping (rs = −0.35–0.58). Measurement invariance testing indicated that the CAMS‐R was invariant across populations of varying genders, cancer types, and stages.ConclusionsFindings provide preliminary support for using the CAMS‐R in cancer populations. Future research should assess the responsiveness of the CAMS‐R to intervention.
Pulmonary functions, nasal symptoms, and quality of life in patients with primary ciliary dyskinesia (PCD)
Authors: Gut Guy , Bar‐Yoseph Ronen , Hanna Moneera , Brandl Noa , Alisha Irit , Rizik Suha , Pollak Mordechai , Hakim Fahed , Amirav Israel , Bentur Lea , Gur Michal 
Published: December 2023

AbstractBackgroundSeveral factors may influence quality of life (QOL) for patients with primary ciliary dyskinesia (PCD). We aimed to evaluate the association between pulmonary functions, nasal symptoms and QOL in PCD patients.MethodsA prospective single center study. Patients performed spirometry, whole body plethysmography, forced oscillation technique (FOT), lung clearance index (LCI), 6‐min walk test (6MWT), and filled two questionnaires: a specific PCD QOL questionnaire (PCD‐QOL) and Sino‐nasal outcome test (SNOT‐22) questionnaire, assessing symptoms of chronic rhinosinusitis and health related QOL.ResultsTwenty‐seven patients (56% females), age 19.4 ± 10.5 years were included; their, FEV1 was 74.6 ± 22.7%, and RV/TLC was (157.3 ± 39.3% predicted). Health perception and lower respiratory symptoms domains of PCD‐QOL had the lowest score (median [IQR]: 50 [33.3−64.6] and 57.1 [38.9−72.2], respectively). FOT parameters correlated with several PCD‐QOL domains. R5 z‐score (indicating total airway resistance) and AX z‐score (indicating airway reactance) correlated negatively with physical domain (r = −0.598, p = .001, and r = −0.42, p = .03, respectively); R5 z‐score also correlated negatively with hearing domain (r = −0.57, p = .002). R5‐20 z‐score (indicating small airway resistance) correlated negatively with role domain (r = −0.49, p = .03). SNOT‐22 score correlated negatively with several PCD‐QOL domains (lower respiratory symptoms r = −0.77, p < .001; physical r = −0.72, p < .001; upper respiratory symptoms r = −0.66, p < .001). No correlations were found between spirometry values, LCI, 6MWT, and PCD‐QOL.ConclusionsFOT suggested small airway dysfunction, and correlated negatively with several PCD‐QOL domains. Nasal symptoms had strong negative correlations with PCD‐QOL. Larger longitudinal studies will further elucidate factors affecting QOL in PCD.
Palivizumab prophylaxis in preterm infants and subsequent wheezing/asthma: 10‐year follow‐up study
Authors: Kato Masahiko , Mochizuki Hiroyuki , Kama Yuichi , Kusuda Satoshi , Okada Kenji , Yoshihara Shigemi , Furuya Hiroyuki , Simões Eric A. F. ,   Scientific Committee for Elucidation of Infantile Asthma (SCELIA)
Published: December 2023

AbstractBackgroundRespiratory syncytial virus (RSV) causes not only infantile recurrent wheezing but also the development of asthma. To investigate whether palivizumab, an anti‐RSV monoclonal antibody, prophylaxis given to preterm infants during the first RSV season reduces the incidence of subsequent recurrent wheezing and/or development of asthma, at 10 years of age.MethodsWe conducted an observational prospective multicenter (52 registered hospitals in Japan) case‐control study in preterm infants with a gestational age between 33 and 35 weeks followed for 6 years. During the 2007−2008 RSV season, the decision to administer palivizumab was made based on standard medical practice (SCELIA study). Here, we followed these subjects until 10 years of age. Parents of study subjects reported the patients' physician's assessment of recurrent wheezing/asthma, using a report card and a novel mobile phone‐based reporting system using the internet. The relationship between RSV infection and asthma development, as well as the relationship between other factors and asthma development, were investigated.ResultsOf 154 preterm infants enrolled, 113 received palivizumab during the first year of life. At 10 years, although both recurrent wheezing and development of asthma were not significantly different between the treated and untreated groups, maternal smoking with aeroallergen sensitization of the patients was significantly correlated with physician‐diagnosed asthma.ConclusionsIn contrast to the prior study results at 6 years, by 10 years palivizumab prophylaxis had no impact on recurrent wheezing or asthma, but there was a significant correlation between maternal passive smoking with aeroallergen sensitization and development of asthma by 10 years of age.
Based on PI‐RADS v2.1 combining PHI and ADC values to guide prostate biopsy in patients with PSA 4−20 ng/mL
Authors: Huang Hua , Liu Zihao , Ma Yuan , Shao Yuan , Yang Zhen , Duan Dengyi , Zhao Yang , Wen Simeng , Tian Jing , Liu Yang , Wang Zeyuan , Yue Dan , Wang Yong 
Published: December 2023

AbstractPurposeThe study aimed to investigate the diagnostic accuracy of prostate health index (PHI) and apparent diffusion coefficient (ADC) values in predicting prostate cancer (PCa) and construct a nomogram for the prediction of PCa and clinically significant PCa (CSPCa) in Prostate Imaging‐Reporting and Data System (PI‐RADS) three lesions cohort.MethodsThis study prospectively enrolled 301 patients who underwent multiparametric magnetic resonance (mpMRI) and were scheduled for prostate biopsy. The receiver operating characteristic curve (ROC) was performed to estimate the diagnostic accuracy of each predictor. Univariable and multivariable logistic regression analysis was conducted to ascertain hidden risk factors and constructed nomograms in PI‐RADS three lesions cohort.ResultsIn the whole cohort, the area under the ROC curve (AUC) of PHI is relatively high, which is 0.779. As radiographic parameters, the AUC of PI‐RADS and ADC values was 0.702 and 0.756, respectively. The utilization of PHI and ADC values either individually or in combination significantly improved the diagnostic accuracy of the basic model. In PI‐RADS three lesions cohort, the AUC for PCa was 0.817 in the training cohort and 0.904 in the validation cohort. The AUC for CSPCa was 0.856 in the training cohort and 0.871 in the validation cohort. When applying the nomogram for predicting PCa, 50.0% of biopsies could be saved, supplemented by 6.9% of CSPCa being missed.ConclusionPHI and ADC values can be used as predictors of CSPCa. The nomogram included PHI, ADC values and other clinical predictors demonstrated an enhanced capability in detecting PCa and CSPCa within PI‐RADS three lesions cohort.
Power to identify exposure‐response relationships in phase IIa pulmonary tuberculosis trials with multi‐dimensional bacterial load modeling
Authors: Koele Simon E. , Dorlo Thomas P. C. , Upton Caryn M. , Aarnoutse Rob E. , Svensson Elin M. 
Published: December 2023

AbstractAdequate power to identify an exposure‐response relationship in a phase IIa clinical trial for pulmonary tuberculosis (TB) is important for dose selection and design of follow‐up studies. Currently, it is not known what response marker provides the pharmacokinetic‐pharmacodynamic (PK‐PD) model more power to identify an exposure‐response relationship. We simulated colony‐forming units (CFU) and time‐to‐positivity (TTP) measurements for four hypothetical drugs with different activity profiles for 14 days. The power to identify exposure‐response relationships when analyzing CFU, TTP, or combined CFU + TTP data was determined at 60 total participants, or with 25 out of 60 participants in the lowest and highest dosing groups (unbalanced design). For drugs with moderate bactericidal activity, power was low (<59%), irrespective of the data analyzed. Power was 1.9% to 29.4% higher when analyzing TTP data compared to CFU data. Combined analysis of CFU and TTP further improved the power, on average by 4.2%. For a drug with a medium‐high activity, the total sample size needed to achieve 80% power was 136 for CFU, 72 for TTP, and 68 for combined CFU + TTP data. The unbalanced design improved the power by 16% over the balanced design. In conclusion, the power to identify an exposure‐response relationship is low for TB drugs with moderate bactericidal activity or with a slow onset of activity. TTP provides the PK‐PD model with more power to identify exposure‐response relationships compared to CFU, and combined analysis or an unbalanced dosing group study design offers modest further improvement.
Ferroptosis: Potential opportunities for natural products in cancer therapy
Authors: Nie Anzheng , Shen Chaozan , Zhou Zheng , Wang Juan , Sun Bao , Zhu Chunsheng 
Published: December 2023

AbstractCancer cells often exhibit defects in the execution of cell death, resulting in poor clinical outcomes for patients with many cancer types. Ferroptosis is a newly discovered form of programmed cell death characterized by intracellular iron overload and lipid peroxidation in the cell membrane. Increasing evidence suggests that ferroptosis is closely associated with a wide variety of physiological and pathological processes, particularly in cancer. Notably, various bioactive natural products have been shown to induce the initiation and execution of ferroptosis in cancer cells, thereby exerting anticancer effects. In this review, we summarize the core regulatory mechanisms of ferroptosis and the multifaceted roles of ferroptosis in cancer. Importantly, we focus on natural products that regulate ferroptosis in cancer cells, such as terpenoids, polyphenols, alkaloids, steroids, quinones, and polysaccharides. The clinical efficacy, adverse effects, and drug–drug interactions of these natural products need to be evaluated in further high‐quality studies to accelerate their application in cancer treatment.
Feasibility‐guaranteed safety‐critical control with high‐order control barrier function method
Authors: Zhang Sihua , Zhai Di‐Hua , Xiong Yuhan , Xia Yuanqing 
Published: December 2023

AbstractThe optimization of control systems under the presence of safety constraints and input constraints frequently involves the decomposition into a sequence of quadratic programs (QPs) facilitated by the utilization of high‐order control barrier function (HOCBF). When the safety constraint conflicts with the input constraint, however, it leads to infeasibility within the QPs. In this article, a feasibility‐guaranteed QP is proposed to tackle the challenge posed by the conflict between HOCBF constraint and input constraint. Firstly, the classical QP is added with a feasibility constraint which is derived from input constraint and HOCBF constraint, where the parameter of feasibility constraint is updated via a new QP obtained by control sharing property. Then, Type‐2 HOCBF is investigated for the system with multiple HOCBF constraints, which effectively confines the system within a single HOCBF at the current time step. Finally, the efficacy of this approach is demonstrated through the application of obstacle avoidance in a 3‐DOF robot system.
Rapid Electrochemical Investigation of Gemfibrozil Using NiONPs/Multiwalled Carbon Nanotube Modified Carbon Paste Electrode: Analysis of Human Urine Sample and Antimicrobial Activity
Authors: Kathrikenahalli Somashekarappa Siddegowda , Basavaraju Mahesh , Nelligere Arakeshwaraiah Chamaraja , Kotthathi Papanna Roopa , Swamy Ningappa Kumara , Soorly Gopala Divakara , Gowda Jayarame 
Published: December 2023

AbstractIn this study, nickel oxide nanoparticles (NiONPs) were produced by the co‐precipitation method and characterized by scanning electron microscopy, X‐ray diffraction (XRD), Fourier transform‐infrared and Ultraviolet‐visible spectroscopy. XRD analysis showed an average crystal size of 6 nm, while SEM analysis exemplified the oblong form with a particle size of 12 nm. As‐prepared NiONPs were combined with multiwalled carbon nanotubes (MWCNTs) and graphite powder to prepare NiONPs‐MWCNTs modified carbon paste electrode (MCPE). The fabricated NiONPs‐MWCNTsMCPE sensor was used to analyze Gemfibrozil (GEM) in pharmaceutical formulations. Electrochemical methods such as cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy employed in sensor characterization and electroanalysis of GEM. The sensor exhibited excellent electrochemical behavior towards GEM. It showed a lower limit of detection (LOD, 2.7×10−8 M), the limit of quantification (LOQ, 9.07×10−8 M), higher sensitivity, higher linear range, and long‐term stability compared to the reported methods. The NiONPs‐MWCNTsMCPE sensor was evaluated for practical application by performing spiking tests in pharmaceutical formulations and human urine samples, demonstrating significant recovery, high effectiveness, and accuracy. Further, nanoparticles manifested promising antibacterial action against Staphylococcus aureus, E. coli, Klebsiella aerogenes, Pseudomonas aeruginosa, and Klebsiella aerogenes.
Development of comprehensive approaches to characterizing CuII complexes: structures in solution and solid‐state, dynamic behavior, and bioactivity
Authors: Ermolaev Anton V. , Shtyrlin Valery G. , Gizatullin Amir I. , Zhernakov Maksim A. , Serov Nikita Yu. , Urazaeva Kira V. , Bukharov Mikhail S. , Gilyazetdinov Edward M. , Islamov Daut R. , Rodionov Alexander A. , Mirzayanov Ildar I. , Garifzyanov Ayrat R. , Kuramshin Bulat K. 
Published: December 2023

AbstractCuII ternary systems with aromatic N‐donors (1,10‐phenanthroline, dipyrido‐[3,2‐f:2’,3’‐h]‐quinoxaline, and 2‐methyldipyrido‐[3,2‐f:2’,3’‐h]‐quinoxaline) and amino acids have been extensively studied in water solution under closely physiological conditions using several techniques, including potentiometric pH titration, mathematical modeling, nuclear magnetic relaxation, EPR, and DFT calculations. Based on the distribution diagrams of the complex species, single crystal syntheses of the ternary systems CuII‐aromatic N‐donor‐L‐amino acid were carried out. As a result, several crystal structures of the complexes with the desired copper‐to‐ligand ratio were established by X‐ray diffraction analysis. The most successful synthetic attempts were with L‐proline and L‐serine, resulting in the crystals with the desired copper(II) to ligand ratio. The developed approach made it possible to thoroughly describe systems with major proteinogenic amino acids in the L‐configuration. Numerous non‐covalent interactions such as H‐bonds, π‐π stacking, d‐π interactions, lone electron pair‐π interactions between CuII atom, conjugated aromatic ligand system, counterions, and water molecules were found to affect the stability and structure of the resulting complex particles. It has been found that in the CuII–N‐donor–amino acid systems there is an acceleration of ligand exchange by a factor of 2–25 compared to CuII‐amino acid systems, which is explained by taking into account steric effects, d‐π interactions, and the pseudo Jahn‐Teller effect. The investigated systems were tested for antitumor activity against MCF‐7, PC‐3, OVCAR‐4, SNB‐19, and M‐14 cell lines, and most samples, in particular, CuII–Phen–L‐His, CuII–MeDPQ−L‐Val and CuII–MeDPQ−L‐Ser, showed a therapeutic activity index greater than 2 for all selected cell types, which opens up prospects for their medical application.
Correlating Young's Modulus with High Thermal Conductivity in Organic Conjugated Small Molecules
Authors: Zeng Jianhui , Liang Ting , Zhang Jingjing , Liu Daoqing , Li Shiang , Lu Xinhui , Han Meng , Yao Yimin , Xu Jian‐Bin , Sun Rong , Li Liejun 
Published: December 2023

AbstractAttaining elevated thermal conductivity in organic materials stands as a coveted objective, particularly within electronic packaging, thermal interface materials, and organic matrix heat exchangers. These applications have reignited interest in researching thermally conductive organic materials. The understanding of thermal transport mechanisms in these organic materials is currently constrained. This study concentrates on N, N'‐dioctyl‐3,4,9,10‐perylenedicarboximide (PTCDI‐C8), an organic conjugated crystal. A correlation between elevated thermal conductivity and augmented Young's modulus is substantiated through meticulous experimentation. Achievement via employing the physical vapor transport method, capitalizing on the robust C═C covalent linkages running through the organic matrix chain, bolstered by π–π stacking and noncovalent affiliations that intertwine the chains. The coexistence of these dynamic interactions, alongside the perpendicular alignment of PTCDI‐C8 molecules, is confirmed through structural analysis. PTCDI‐C8 thin film exhibits an out‐of‐plane thermal conductivity of 3.1 ± 0.1 W m−1 K−1, as determined by time‐domain thermoreflectance. This outpaces conventional organic materials by an order of magnitude. Nanoindentation tests and molecular dynamics simulations elucidate how molecular orientation and intermolecular forces within PTCDI‐C8 molecules drive the film's high Young's modulus, contributing to its elevated thermal conductivity. This study's progress offers theoretical guidance for designing high thermal conductivity organic materials, expanding their applications and performance potential.
Exploring the links between types 2 diabetes and liver‐related complications: A comprehensive review
Authors: Otero Sanchez Lukas , Chen Yuping , Lassailly Guillaume , Qi Xiaolong 
Published: December 2023

AbstractIn recent decades, the prevalence of type 2 diabetes has been steadily increasing, presenting a significant global public health challenge. These epidemiological trends can be attributed to significant lifestyle changes in modern societies, characterized by sedentary behavior and the consumption of hypercaloric, highly processed foods, along with the aging of the human population. As a result, it has become crucial for both public healthcare systems and healthcare providers to prioritize the management of diabetes and identify its systemic consequences. Emerging research has shed light on the links and risks between diabetes and liver events. This comprehensive review aims to explore the complex interplay between type 2 diabetes mellitus and liver‐related outcomes, especially hepatocellular carcinoma and cirrhosis, offering insights into effective methods for detecting liver risk in individuals with diabetes. Additionally, the review will assess the various treatments that could hold the potential for positive outcomes in managing both diabetes and metabolic dysfunction‐associated steatotic liver disease and liver fibrosis.