bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of midurethral sling in the correction of low-stage cystoceles: a prospective randomized trial
Authors: Ramadan Diaeldin T. , Elhefnawy Ahmed S. , Wadie Bassem S. 
Published: December 2023

Abstract
Introduction and hypothesis
The objective was to assess whether midurethral slings (MUS) can improve both stress urinary incontinence (SUI) and cystoceles. MUS with anterior colporrhaphy (AC) as a treatment for SUI with cystocele is more invasive and carries greater risk than MUS alone.

Methods
This is a prospective randomized study involving women with stage 1 or 2 cystocele and SUI, who were > 21 years of age, who had had no previous surgery for SUI. Predominant SUI, symptomatic anterior pelvic organ prolapse, and informed consent were mandatory. Patients were randomized as to whether AC had been performed. The sling procedure was left to the surgeon’s discretion: pubovaginal sling, tension-free vaginal tape, or trans-obturator tape. Success was defined as a negative stress test and no evidence of cystocele upon local examination.

Results
Ninety-eight patients were enrolled, 48 underwent MUS, and 50 underwent MUS and AC. Mean age ± SD was 44.96 ± 8.13 years. Baseline characteristics were similar. Operative time and blood loss were significantly higher in the MUS/AC group (p = 0.01 and 0.02 respectively). At 3 months, success was 79.1% and 77.8% in the MUS and MUS/AC groups respectively. This was maintained until 6 months (79.1% and 77.8% respectively). At 1 year, the results were comparable with success rates of 96.2% and 87.0% in the MUS and MUS and AC groups respectively. Symptom scores were comparable at 6- and 12-month evaluations.

Conclusion
Midurethral slings correct symptomatic stage 1 or 2 cystoceles without the need for AC, which carries the risk of a significantly longer procedure and more significant blood loss.
Comparison of calibration strategies for accurate quantitation by isotope dilution mass spectrometry: a case study of ochratoxin A in flour
Authors: Bates Jennifer , Bahadoor Adilah , Tittlemier Sheryl A. , Melanson Jeremy E. 
Published: December 2023

AbstractAnalysis of low-level organic contaminants in complex matrices is essential for monitoring global food safety. However, balancing sample throughput with complex experimental designs and/or sample clean-up to best reduce matrix effects is a constant challenge. Multiple strategies exist to mitigate these effects, with internal standard-based methods such as isotope dilution mass spectrometry (IDMS) being the most advantageous. Here, multiple internal calibration strategies were investigated for the quantification of ochratoxin A (OTA) in wheat samples by liquid chromatography-mass spectrometry (LC-MS). Internal standard-based quantitation methods such as single (ID1MS), double (ID2MS), and quintuple (ID5MS) isotope dilution mass spectrometry, as well as external standard calibration, were explored and compared. A certified reference material (CRM) of OTA in flour, MYCO-1, was used to evaluate the accuracy of each method. External calibration generated results 18–38% lower than the certified value for MYCO-1, largely due to matrix suppression effects. Concurrently, consistently lower OTA mass fractions were obtained for the wheat samples upon quantitation by external calibration as opposed to ID1MS, ID2MS, and ID5MS. All isotope dilution methods produced results that fell within the expected range for MYCO-1 (3.17–4.93 µg/kg), validating their accuracy. However, an average 6% decrease in the OTA mass fraction was observed from results obtained by ID1MS compared to those by ID2MS and ID5MS. Upon scrutiny, these differences were attributed to an isotopic enrichment bias in the isotopically labelled internal standard [13C6]-OTA that was used for ID1MS, the OTAL-1 CRM. The advantages and limitations of each isotopic method are illustrated.
A systematic review of (semi-)automatic quality control of T1-weighted MRI scans
Authors: Hendriks Janine , Mutsaerts Henk-Jan , Joules Richard , Peña-Nogales Óscar , Rodrigues Paulo R. , Wolz Robin , Burchell George L. , Barkhof Frederik , Schrantee Anouk 
Published: December 2023

Abstract
Purpose
Artifacts in magnetic resonance imaging (MRI) scans degrade image quality and thus negatively affect the outcome measures of clinical and research scanning. Considering the time-consuming and subjective nature of visual quality control (QC), multiple (semi-)automatic QC algorithms have been developed. This systematic review presents an overview of the available (semi-)automatic QC algorithms and software packages designed for raw, structural T1-weighted (T1w) MRI datasets. The objective of this review was to identify the differences among these algorithms in terms of their features of interest, performance, and benchmarks.

Methods
We queried PubMed, EMBASE (Ovid), and Web of Science databases on the fifth of January 2023, and cross-checked reference lists of retrieved papers. Bias assessment was performed using PROBAST (Prediction model Risk Of Bias ASsessment Tool).

Results
A total of 18 distinct algorithms were identified, demonstrating significant variations in methods, features, datasets, and benchmarks. The algorithms were categorized into rule-based, classical machine learning-based, and deep learning-based approaches. Numerous unique features were defined, which can be roughly divided into features capturing entropy, contrast, and normative measures.

Conclusion
Due to dataset-specific optimization, it is challenging to draw broad conclusions about comparative performance. Additionally, large variations exist in the used datasets and benchmarks, further hindering direct algorithm comparison. The findings emphasize the need for standardization and comparative studies for advancing QC in MR imaging. Efforts should focus on identifying a dataset-independent measure as well as algorithm-independent methods for assessing the relative performance of different approaches.
Cosmetic Breast Augmentation with Autologous Ex Vivo-Expanded Adipose-Derived Mesenchymal Stem/Stromal Cell (Stemform®)-Enriched Fat Grafts: A Study of the First Twenty-Two Real-World Patients
Authors: Mamsen Frederik Penzien Wainer , Fischer-Nielsen Anne , Svalgaard Jesper Dyrendom , Jensen Jesper Due , Jønsson Bo , Duscher Dominik , Christensen Josef , Van Leeuwen Michiel , Kiilerich Claes Hannibal , Roider Laura , Sterodimas Aris , Munthe-Fog Lea , Kølle Stig-Frederik Trojahn 
Published: December 2023

Abstract
Background
Fat grafting is commonly utilized in breast surgery, and since it was first described, clinicians and researchers have stridden towards improvement of graft retention. Current advancements include adding adipose-derived mesenchymal stem/stromal cells (MSC(AT)s), which have demonstrated promise for improved graft retention.

Objectives
This study reports outcomes for the first twenty-two patients undergoing breast augmentation (Stemform BA) or artificial implant replacement (Stemform AIR) with MSC(AT)-enriched fat in a real-world setting.

Methods
Autologous MSC(AT)s were isolated and expanded ex vivo, then mixed with lipoaspirate and injected as enriched fat for Stemform BA and AIR. The breast volume was measured preoperatively and at 3 and 12 months postoperative using a 3D Infinity Dual-Lens Camera and LifeVizApp software. Additionally, independent plastic surgeons evaluated clinical images, and patient satisfaction was obtained at equal time points.

Results
Twenty-two patients were included. All completed 3 and 12 months clinical follow-up and 3 months volume measurements. Nineteen patients completed 12 months volume measurements. The median fat graft retention at 12 months was 95.7% (IQR = 82.44–103.12%) for Stemform BA patients and 113.0% (IQR = 94.8–131.2%) for Stemform AIR patients. The Stemform BA patients had a median breast enlargement of 172.0% (IQR = 156.7–241.0%). The implant replacement volume of Stemform AIR patients was 102% (IQR = 85.1–130.3%). The patient reported 92.8% and 100% would elect to repeat treatment if they had the opportunity for Stemform BA and Stemform AIR, respectively.

Conclusion
Breast augmentation and breast implant replacement patients receiving ex vivo-expanded MSC(AT)-enriched fat grafts had high graft retention and patient satisfaction scores. The paper confirms the clinical efficacy of using ex vivo-expanded MSC(AT)s.
Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
What is new in the classification of peripheral T cell lymphomas?
Authors: de Leval Laurence , Bisig Bettina 
Published: December 2023

AbstractIn this review focus article, we highlight the main modifications introduced in the latest 2022 International Consensus Classification and World Health Organization classification (ICC and WHO-HAEM5) of mature T (and NK) cell neoplasms (PTCLs) and consequent implications for diagnostic practice. The changes result from recent advances in the genomic and molecular characterization of PTCLs and enhanced understanding of their pathobiology. Specifically, consideration is given to the following groups of diseases: Epstein–Barr virus (EBV)-associated neoplasms; follicular helper T cell lymphoma; anaplastic large cell lymphomas; primary intestinal T and NK cell lymphomas and lymphoproliferative disorders; and PTCL, not otherwise specified.
Regulation (EU) 2017/746 (IVDR): practical implementation of annex I in pathology
Authors: Kahles Andy , Goldschmid Hannah , Volckmar Anna-Lena , Ploeger Carolin , Kazdal Daniel , Penzel Roland , Budczies Jan , Flechtenmacher Christa , Gassner Ulrich M. , Brüggemann Monika , Vogeser Michael , Schirmacher Peter , Stenzinger Albrecht 
Published: December 2023

Abstract
Background
Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR) imposes several conditions on pathology departments that develop and use in-house in vitro diagnostic medical devices (IH-IVDs). However, not all of these conditions need to be implemented immediately after the IVDR entered into force on 26 May 2022. Based on an amending regulation of the European Parliament and the Council of the European Union, the requirements for IH-IVDs will be phased in. Conformity with the essential safety and performance requirements of annex I must be ensured from May 2022.

Objectives
With this article, we would like to present the practical implementation of the currently valid conditions for IH-IVDs at the Institute of Pathology at the University Hospital of Heidelberg, in order to provide possible assistance to other institutions.

Conclusions
In addition to the intensive work on the requirements for IH-IVDs, several guidance documents and handouts provide orientation for the implementation and harmonisation of the requirements for healthcare institutions mentioned in Article 5 (5). Exchange in academic network structures is also of great importance for the interpretation and practical implementation of the IVDR. For university and nonuniversity institutions, ensuring conformity with the IVDR represents a further challenge in terms of personnel and time, in addition to the essential tasks of patient care, teaching and research and the further development of methods for optimal and targeted diagnostics, as well as the maintenance of the constantly evolving quality management system.
The interplay between agriculture, greenhouse gases, and climate change in Sub-Saharan Africa
Authors: Omotoso Abeeb Babatunde , Omotayo Abiodun Olusola 
Published: December 2023

AbstractAgriculture is the leading sector that is responsible for global climate change through its significant contribution to greenhouse gas (GHG) emissions. Intriguingly, sub-Saharan Africa (SSA) is experiencing higher temperatures and lesser rainfall due to climate change enhanced by anthropogenic GHG emissions. Agriculture and energy use in the SSA predominantly influence the anthropogenic GHG leading to global warming. Therefore, reducing agricultural GHG emissions (such as carbon dioxide, nitrous oxide, and methane) plays a significant role in climate change adaptation. This paper reviews the potential implication of agriculture and energy use on climate change and its implications on environmental sustainability in SSA. Herewith, we explored various GHGs emitted through agriculture-energy use, their effects on climate change, as well as several climate change adaptation mechanisms, and gaps in existing knowledge that necessitate more research, were also explored. We found that agriculture had negative implications on climate change impacts in the SSA countries and that a more focused strategy that is both economically and technically feasible in terms of preferences for land use, effective energy use, and food supply would aid in GHG emission reduction and environmental sustainability. Adapting to the projected changes in the short term while investing in long-term mitigation strategies might be the only way toward a sustainable environment in this region.
Frobenius Kernels of Algebraic Supergroups and Steinberg’s Tensor Product Theorem
Authors: Shibata Taiki 
Published: December 2023

AbstractFor a split quasireductive supergroup $$\mathbbm {G}$$
G
defined over a field, we study structure and representation of Frobenius kernels $$\mathbbm {G}_r$$

G
r

of $$\mathbbm {G}$$
G
and we give a necessary and sufficient condition for $$\mathbbm {G}_r$$

G
r

to be unimodular in terms of the root system of $$\mathbbm {G}$$
G
. We also establish Steinberg’s tensor product theorem for $$\mathbbm {G}$$
G
under some natural assumptions.
Evaluating support systems and interface efficiency in Hour of Code’s Minecraft Adventurer
Authors: Toukiloglou Pavlos , Xinogalos Stelios 
Published: December 2023

AbstractHour of Code is a widely recognized global event that aims to introduce programming to novice users and integrate computer science into education. This paper presents an analysis of the effectiveness of the support system and user interface of Minecraft Adventurer, a serious game designed for the Hour of Code global event. Although previous studies have primarily focused on the educational benefits of Hour of Code games, there has been limited research on their support methods. Therefore, this paper aims to address this gap with an empirical study of the experience of 104 students who played the game for one hour. Student progress was tracked by an administering teacher and after the game session, a questionnaire was administered to collect data on the participant’s perceptions of the support system, interface efficiency, and overall experience with Hour of Code. The results of the study reveal significant problems with the aforementioned systems, which apply not only to Minecraft Adventurer but also to several other similar serious games. Additionally, the findings showed a correlation between the utilization of the support system and student performance, indicating that student’s comprehension of the support system significantly influences their learning outcomes. This paper concludes by providing potential solutions to address the identified insufficiencies, offering valuable insights for future researchers and game developers on the design and evaluation of serious games for educational purposes.
A new skeletal model for the ankle joint complex
Authors: Rodrigues da Silva Mariana , Marques Filipe , Tavares da Silva Miguel , Flores Paulo 
Published: December 2023

AbstractThe talocrural and the talocalcaneal articulations collectively form the ankle joint complex of the human foot and are the focus of investigation of this work. The talocrural articulation enables plantarflexion and dorsiflexion, while the talocalcaneal articulation allows inversion and eversion of the foot. A comprehensive analysis of the literature suggests that the ankle joint complex is modeled in different manners considering approaches with varying complexity levels, which more or less accurately mimic its intrinsic anatomical features. Several studies assume that the foot articulates with the leg via the talocrural articulation only, which is modeled as a revolute joint. Other studies consider the movements allowed by both articulations and model the ankle joint complex as spherical, revolute, or classical universal joints. Most existing approaches do not consider sufficiently accurate anatomical modeling of this joint complex. Thus, this work presents a new skeletal model for the ankle joint complex of the human foot that considers the actual anatomy and movements of the talocrural and the talocalcaneal articulations. The proposed approach uses a modified universal joint, which incorporates a massless link to mimic the actual function of the talus bone. The developed formulation is compared with a model available in the literature, which uses a classical universal joint. The outcomes show that modeling the ankle joint complex as a modified universal joint allows a more realistic representation of the anatomy of the human foot. The main differences between the two joint models are observed in the mediolateral direction.
There is only one más: Spanish que/de comparative alternation
Authors: Toquero-Pérez Luis Miguel 
Published: December 2023

AbstractSpanish has two forms to introduce comparative standards: que ‘that’ and de ‘of.’ The comparative morpheme is always the same más ‘-er/more.’ While que-comparatives show no variation in their syntactic properties, there is significant variation within de-comparatives regarding extraposition, scope, ACD resolution and the syntax of comparative numerals. Despite this variation, I argue that a uniform account is possible. I propose that más has the same syntax across the board (i.e. it takes the late-merged standard as complement, Bhatt and Pancheva 2004) and semantically it is a generalized quantifier over degrees (Heim 2001). The analysis (i) ensures that más and the standard form a constituent, (ii) allows for inverse scope, ACD resolution inside the standard of comparison and extraposition.
Organizational or Individual? The Effect of Social Networks on Volunteer Activities in Japan
Authors: Kojima Megumi 
Published: December 2023

AbstractThis paper investigates what kinds of social networks nudge volunteering by applying social network analysis. Unique Japanese data with various social network variables are used to explore the association between formal and informal social networks and volunteering. The results show that “attending meetings of neighborhood associations” and “enrollment in a membership association,” which involve forms of formal social networks, are positively correlated with the probability of both “any volunteering” and five kinds of volunteering. “Frequency of meals with friends,” an indicator of informal social networks, has statistical significance for volunteering. Notably, friendships, even if meals are infrequent, are enough to lead to volunteering opportunities. The author thus concludes that greater social participation can be fostered by promoting not only organizational assistance but also friendships.
High-temperature tribological performance of functionally graded Stellite 6/WC metal matrix composite coatings manufactured by laser-directed energy deposition
Authors: Ostolaza Marta , Zabala Alaitz , Arrizubieta Jon Iñaki , Llavori Iñigo , Otegi Nagore , Lamikiz Aitzol 
Published: December 2023

AbstractWear-driven tool failure is one of the main hurdles in the industry. This issue can be addressed through surface coating with ceramic-reinforced metal matrix composites. However, the maximum ceramic content is limited by cracking. In this work, the tribological behaviour of the functionally graded WC-ceramic-particle-reinforced Stellite 6 coatings is studied. To that end, the wear resistance at room temperature and 400 °C is investigated. Moreover, the tribological analysis is supported by crack sensitivity and hardness evaluation, which is of utmost importance in the processing of composite materials with ceramic-particle-reinforcement. Results indicate that functionally graded materials can be employed to increase the maximum admissible WC content, hence improving the tribological behaviour, most notably at high temperatures. Additionally, a shift from abrasive to oxidative wear is observed in high-temperature wear testing.
Nano-frictional mechano-reinforcing porous nanowires scaffolds
Authors: Hua Licheng , Hu Conghu , Zhang Jingkang , Li Jin , Gu Chenjie , Huang Bin , Li Guangyong , Du Jianke , Guo Wanlin 
Published: December 2023

AbstractArtificial biomaterials with dynamic mechano-responsive behaviors similar to those of biological tissues have been drawing great attention. In this study, we report a TiO2-based nanowire (TiO2NWs) scaffolds, which exhibit dynamic mechano-responsive behaviors varying with the number and amplitude of nano-deformation cycles. It is found that the elastic and adhesive forces in the TiO2NWs scaffolds can increase significantly after multiple cycles of nano-deformation. Further nanofriction experiments show the triboelectric effect of increasing elastic and adhesive forces during the nano-deformation cycles of TiO2NWs scaffolds. These properties allow the TiO2NW scaffolds to be designed and applied as intelligent artificial biomaterials to simulate biological tissues in the future.
Generating synthetic as-built additive manufacturing surface topography using progressive growing generative adversarial networks
Authors: Seo Junhyeon , Rao Prahalada , Raeymaekers Bart 
Published: December 2023

AbstractNumerically generating synthetic surface topography that closely resembles the features and characteristics of experimental surface topography measurements reduces the need to perform these intricate and costly measurements. However, existing algorithms to numerically generated surface topography are not well-suited to create the specific characteristics and geometric features of as-built surfaces that result from laser powder bed fusion (LPBF), such as partially melted metal particles, porosity, laser scan lines, and balling. Thus, we present a method to generate synthetic as-built LPBF surface topography maps using a progressively growing generative adversarial network. We qualitatively and quantitatively demonstrate good agreement between synthetic and experimental as-built LPBF surface topography maps using areal and deterministic surface topography parameters, radially averaged power spectral density, and material ratio curves. The ability to accurately generate synthetic as-built LPBF surface topography maps reduces the experimental burden of performing a large number of surface topography measurements. Furthermore, it facilitates combining experimental measurements with synthetic surface topography maps to create large data-sets that facilitate, e.g. relating as-built surface topography to LPBF process parameters, or implementing digital surface twins to monitor complex end-use LPBF parts, amongst other applications.
The known ending: narrative closure and reading experience in Dream of the Red Chamber
Authors: Zhao Eileen Yiran 
Published: December 2023

AbstractDifferent from most traditional Chinese full-length novels, Dream of the Red Chamber紅樓夢written by Cao Xueqin 曹雪芹 (1710?—1765?) begins its narrative by declaring that the whole story in its entirety has been finished and completed. This essay approach this narrative design from a different perspective, namely, the temporal structure and explore how the emplotments with a predestined ending point right at the beginning of the novel are constructed and their effects on the reader's experience. To better illustrate this mechanism, I will first examine the indication of a known ending in the framework of narrative theory and then look into the twofold layers that the novel adopts in its first chapter to persuade its readers that the whole story is built on a recollection and remembrance. In doing so, I explore how the construction of a known ending beforehand affects the reading experience at the cognitive and affective levels.