bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient’s satisfaction and service quality of clinical laboratory: A questionnaire based analysis in accredited tertiary care government hospital
Authors: Raj Swati , Nath Unnati , Gulati Natasha , Sinha Madhu , Das Abhijit 
Published: January 2024

The Phlebotomy is the first phase of interaction of the patient to the laboratory. It is therefore considered as an important step of good clinical laboratory practice and is referred to as "pre-analytic phase”. Patient’s satisfaction is one of the key quality indicators in the laboratory. : To assess the patient's satisfaction , to investigate, monitor, and analyse the non-conformities in order to remove the root cause by performing corrective and preventive action in order to improve the quality of laboratory services.: A cross-sectional study conducted in a NABH/NABL accredited government super-speciality hospital on 1500 patients over a period of three months. Data were collected in a self administered predesigned, pretested, structured questionaired feedback form in both Hindi and English, further reviewed by Senior Pathologist in a quality assurance meet and CAPA.A statistical analysis performed by using SPSS version 16.0 software and Likert Scale.Overall patient satisfaction with phlebotomy services found to be high, i.e 88%. Highest mean rating of satisfaction was 99.2% for parameter -Whether the seats during phlebotomy was comfortable. The parameter for washroom facility accounted for 75 % dissatisfaction followed by 63.4% overall dissatisfaction noted for ambulatory services. Phlebotomy services needs improvements: 12%.The study enlighten to understand patient preferences through a patient satisfaction questionnaire known as a "feedback form." Knowing how our patients feel about our laboratory services is vital and to identify all problems (non-conformities) found in the analysis and take appropriate CAPA.
Manual versus automated method for reticulocyte count: A comparative study
Authors: Singh Mitali , Mane Vaibhav P 
Published: January 2024

To compare the reliability and degree of acceptability of manual reticulocyte count over automated method in Tertiary Care Hospital: Reticulocytes are precursory to erythrocyte cells released from bone marrow into the blood and their evaluation is helpful in early diagnosis as well as therapeutic monitoring of anemic patients. Reticulocyte count is a rapid and basic hematological test that measures the erythropoietic activity within the bone marrow. An analytical and observational hospital-based study was conducted on all EDTA blood samples received for reticulocyte count by both manual and automated methods. A comparison of both methodologies was done. An evaluation of 230 blood samples was conducted and it showed a strong correlation between both methodologies with a p-value more than 0.05. The study suggests that the manual method for reticulocyte count is as reliable as an automated method. Its cost-effectiveness and reliability are useful in small urban laboratories and also in remote rural areas for early diagnosis as well as treatment of anemia.
Congratulations! MURAKAMI Suminao Award for Disaster Research 2023 and the JDR Annual Awards 2023
Authors:   Editorial Office
Published: January 2024

We are pleased to announce that the MURAKAMI Suminao Award for Disaster Research and the JDR annual awards (the JDR Award for the Most Cited Paper, the JDR Award for the Most Downloaded Article, and the JDR Award for the Most Contributory Reviewer) of 2023 have been decided by the JDR editorial boards. The award ceremony was held on December 6, 2023 at Gakushikaikan, Tokyo, Japan. We congratulate the winners and sincerely wish for future success.
MURAKAMI Suminao Award for Disaster Research 2023
Prof. Fumihiko Imamura (Tohoku University)
JDR Award for the Most Cited Paper 2023
Ryohei Kato, Ken-ichi Shimose, and Shingo Shimizu
Predictability of Precipitation Caused by Linear Precipitation Systems During the July 2017 Northern Kyushu Heavy Rainfall Event Using a Cloud-Resolving Numerical Weather Prediction Model
JDR Vol.13 No.5 pp. 846-859, 2018
JDR Award for the Most Downloaded Article 2023
Chun-Hao Shao, Pei-Chun Shao, and Fang-Ming Kuo
Stampede Events and Strategies for Crowd Management
JDR Vol.14 No.7 pp. 949-958, 2019
JDR Award for the Most Contributory Reviewer 2023
Prof. Reo Kimura (University of Hyogo)
LA LEGISLACIÓN SOBRE CAMINOS ESPAÑOLES EN EL SIGLO XVIII. UNA CONTRIBUCIÓN A SU ESTUDIO
Authors: Hurtado de Molina Julián 
Published: January 2024

En el siglo XVIII, el siglo de las Luces, durante el reinado de Carlos III, se pone de manifiesto en los territorios de la corona española, la falta de comunicación entre las provincias del interior y las marítimas, indispensable para el fomento de la industria y el comercio, así como para una explotación rentable de la agricultura.
Los nuevos postulados ilustrados de la época, sitúan a este siglo XVIII como el de los caminos de España, por cuanto se inicia una legislación en sentido estricto para su construcción, conservación y protección.
En 1761 se promulgó el primer Decreto que clasificó las carreteras e impulsó el primer plan general, en el que se establecían las actuaciones en tal sentido, señalando plazos de ejecución de las obras y determinando los modos de financiación de las mismas.

El Plan de Esquilache (Leopoldo de Gregorio y Masnata, marqués de Esquilache, 1699-1785), como encargado de Hacienda y Superintendente General, presentó al rey Carlos III este esencial Plan, punto de arranque de los que posteriormente se redactaron. El plan consistía en el ensanchamiento de antiguas vías, en el empedrado de ciertos tramos, en el aumento de la longitud de la red e, incluso, en la creación de nuevos trazados que acortaran distancias.
Por causas de insuficiente preparación técnica y otras carencias, no se cumplieron todas las previsiones de dicho Plan, obteniéndose escaso rendimiento de los grandes recursos y esfuerzos que para su realización se habían destinado.
Tales deficiencias se expresaron posteriormente, ya en el siglo XIX, por medio del llamado Informe Betancourt, elaborado por quien fue el fundador de la Escuela de Ingenieros de Caminos y Canales del Reino de España
LA RAZÓN MANDA. LA INCOMPARABLE TRANSICIÓN
Authors: CASAÑO SALIDO CARMELO 
Published: January 2024

Como, ahora, a pocas fechas de cumplirse los 45 años de las primeras elecciones democráticas, en determinados grupos de opinión, se habla de que España necesitaría, para superar el tiempo difícil que se avecina, un gran pacto de Estado, semejante al que existe en la República Federal Alemana desde hace más de un lustro, nos parece oportuno recordar que, en puridad, nuestra Transición fue un amplio e insólito acuerdo estatal, aunque todavía existan españoles, primordialmente jóvenes, que la desconocen, y eso que el antiquísimo Herodoto enseñó que “la Historia es la gran maestra de la vida”. Historia, debemos matizar que, al contrario de lo afirmado por Gimbatista Vico en pleno barroco absolutista, nunca se repite aunque, en ocasiones, pueda parecerse. También, hay que tener bien presente, cuando se trata de enjuiciar –como haremos a continuación-, la acción pública que, de acuerdo con Bismark, “la política es el arte de lo posible”. Pero conseguir lo posible siempre demanda un conocimiento preciso de los aconteceres pasados y actuar, desde las urgencias del presente, con perspectivas de futuro
NUEVE REFLEXIONES EN TORNO A LA TRANSICIÓN ESPAÑOLA
Authors: CASAÑO SALIDO CARMELO 
Published: January 2024

Se recogen en nueve calas, o prospecciones, todo lo que tengo pensado sobre la Transición y que -insisto- es el germen de nuestras ideas, plasmadas en la conferencia sobredicha. Como es normal en estos casos, habrá repeticiones, lógicos retornos que no me preocupan desde que André Gide nos enseñó que, aun estando todo dicho, el escritor debe repetir los pensamientos cardinales, pues cada vez escasean más los que leen, entienden y recuerdan
Data recovery methods for DNA storage based on fountain codes
Authors: Schwarz Peter , Freisleben Bernd 
Published: January 2024

Abstract

Today’s digital data storage systems typically offer advanced data recovery solutions for the problem of catastrophic data loss. For conventional hard disk drives, several data recovery mechanisms are available, ranging from software-based disk sector or file analysis to physicallevel data retrieval methods. In contrast, DNA-based data storage exclusively relies on the inherent error correction properties of the encoding methods employed to encode digital data into strands of DNA. In this article, we propose a novel approach to provide data recovery in DNA storage systems. In particular, we present a novel method to automatically reconstruct original data from corrupted data stored and encoded in DNA using fountain codes. Our method exploits the intrinsic relationships between processed packets encoded with fountain codes to identify and rectify errors. Furthermore, we present file type-specific and contentbased error detection and correction methods for three file types, illustrating how a fusion of fountain encoding-specific redundancy and knowledge about the stored data can effectively recover information in a partially corrupted DNA storage system, both in an automatic and in a guided manual manner. To demonstrate the feasibility of our approach, we introduce DR4DNA, a software toolkit that contains all methods presented in this work. Compared to conventional DNA error correction schemes, our approach introduces a fallback recovery approach similar to data recovery services for hard drives. We evaluate DR4DNA using both in-silico and in-vitro experiments.
Hypoxia-induced epigenetic regulation of miR-485-3p promotes stemness and chemoresistance in pancreatic ductal adenocarcinoma via SLC7A11-mediated ferroptosis
Authors: Yang Yinmo , Tian Xiaodong , liu xinxin , Huang Zhihua , Chen Qiuzheng , Chen Kai , Liu Weikang , Liu Guangnian , Chu Xiangyu , Li Dongqi , Ma Yongsu 
Published: January 2024

Abstract

The mechanism of hypoxia in chemoresistance of pancreatic ductal adenocarcinoma (PDAC) remains elusive. In this study, we reveled essential role of miR-485-3p in PDAC, particularly its impact on cancer stemness and gemcitabine resistance under hypoxic condition. We found substantial downregulation of miR-485-3p in PDAC tissues, with lower expression correlating to poor patient outcomes. Mechanistically, miR-485-3p influenced stemness characteristics, as evidenced by reduced tumor sphere formation and increased sensitivity to gemcitabine upon overexpression. Moreover, we identified SOX9 and SLC7A11 as two targets of miR-485-3p, which play vital role in stemness and ferroptosis. Under hypoxic condition, DNMT3B expression was upregulated, leading to hypermethylation of miR-485-3p promoter region. the reduced miR-485-3p expression promoted stemness and chemoresistance of PDAC. In conclusion, our findings elucidate the intricate interplay of hypoxia, epigenetic modifications, and ferroptosis in PDAC and shed light on potential avenues for targeted interventions that modulate cancer stemness and chemosensitivity, offering prospects for improved therapeutic strategies for PDAC.
Genome-wide characterization and analysis of rice DUF247 gene family
Authors: Zhang Feifei , Yang Jun , Sohail Amir , Lu Chengkai , Xu Peng 
Published: January 2024

Abstract

Background
The domain of unknown function 247 (DUF247) proteins are involved in plant development and stress response. Rice is an important worldwide cereal crop, although an increasing number of DUF proteins have been identified, the understanding of DUF proteins is still very limited in rice.
Results
In this study, we identified 69 genes that encode DUF247 proteins in the rice (Oryza sativa) genome by homology searches and domain prediction. All the OsDUF247 proteins were classified into four major groups (I, II, III and IV) by phylogenetic analysis. Remarkably OsDUF247 genes clustered on the chromosomes solely show close phylogenetic relationships, suggesting that gene duplications driven the expansion of the DUF247 gene family in the rice genome. The tissue profile analysis showed that most DUF247 genes expressed at constitutive levels in seedlings, roots, stems, and leaves, except for seven genes (LOC_Os01g21670, LOC_Os03g19700, LOC_Os05g04060, LOC_Os08g26820, LOC_Os08g26840, LOC_Os08g26850 and LOC_Os09g13410) in panicles. These seven genes were induced by various abiotic stress, including cold, drought, heat, hormone treatment, and especially salt, as demonstrated by further experimental analysis. DUF247 proteins contain transmembrane domains located on the membrane, suggesting their significant roles in rice development and adaptation to the environment.
Conclusions
These findings lay the foundation for functional characterizations of DUF247 genes to unravel their exact role in rice cultivars.
Synchronized Incidental Affect Changes Ambiguity Preferences
Authors: Sambrano Deshawn , Dong Bryan , Glimcher Paul , Phelps Elizabeth A. 
Published: January 2024

Abstract

Decisions under uncertainty are prevalent, but come under two distinct types. Risk, which has unknown outcomes but known probabilities for those outcomes and ambiguity which contains both unknown outcomes and unknown probabilities. Although there have been several studies linking affect and aversion to ambiguity, there have been no studies that have to identify how changing one’s affective response can change their choices. A total of 166 adults (M = 36.54, SD = 11.80) participated in an online study through Prolific. Participants were presented with a lottery on each trial which varied on its uncertainty type (risky vs ambiguous) and winning characteristics (winning probability and amount). Half of the ambiguous lotteries were paired with an neutral image (e.g., office supplies), while the other half was paired with an emotionally evocative image (e.g., burning house) that was hypothesized to incidentally influence their decisions. As measured by both raw choice data as well as through a computational model, participants were more averse to ambiguity when the lottery was paired with an emotionally evocative image. Follow-up analyses revealed that only lotteries in which the computational model predicted the participant would choose the lottery were affected by the images. This study highlights the phenomenon in which one’s awareness of an affective stimulus can alter its impact on their decisions.
Intellectual Property Protection, Product Life-cycle Lengths, and the Boundaries of Multinational Corporations
Authors: Zhang Yiming , Ye Zuoliang , Li Yunong 
Published: January 2024

Abstract

This paper presents a theoretical model based on transaction cost analysis and the resource-based view. It establishes that the corporate boundaries of multinational corporations are determined by the length of the product life cycle and the level of intellectual property protection in the host country. The empirical results based on the panel data of U.S. multinational corporations' import trade of 208 types of products in 18 countries from 2002 to 2013 validate the extrapolation results of the theoretical model. The study finds that the most significant determinants of multinational corporations' boundaries are the length of the product life cycle and the level of IPR protection in the host country.
Comparative Assessment of the Impact of COVID-19 Lockdown on Air Quality: A Multinational Study of SARS-CoV-2 Hotspots
Authors: Boudia Ahmed Ould , Asheesh Mohamed , Adusei-Mensah Frank , Bounab Yazid 
Published: January 2024

Abstract
In response to the global COVID-19 pandemic, nations implemented lockdown measures to contain the virus. This study assessed air pollution levels during and after lockdowns, focusing on heavily affected locations: Oulu and Helsinki in Finland, Paris in France, Madrid in Spain, Milan in Italy, and Wuhan in China. Air Quality Index (AQI) data from these areas over two years were analyzed to understand lockdown effects. COVID-19 lockdowns in six cities were compared with SARS-CoV-2 measures using statistical methods. Pollutant Outdoor variations were evaluated via tests, showing significant differences. Parametric analyses and regression studied lockdown impacts on pollution and relationships. The study comprehensively analyzed COVID-19 lockdowns' effects on air quality, identifying differences, quantifying changes, and exploring patterns in Oulu and Helsinki. Pollutant correlations varied among cities during lockdowns. Regression analysis highlighted independent variables' impact on pollutants. Decreases in NO2 were seen in Helsinki, Madrid, Oulu, Paris, and Milan, reflecting reduced traffic and industry. PM2.5 and PM10 reductions occurred in these cities and also Wuhan, except for O3 levels which increased. Reduced human activities improved air quality, especially for NO2 and PM10. Regional variations necessitate tailored interventions. We observed that during the COVID-19 lockdowns, there was a substantial decrease in both PM2.5 and NO2 levels, indicating a direct correlation between reduced human activities, such as transportation and industrial operations, and improved air quality. This underscores the potential impact of environmental measures and suggests the need for sustainable practices to mitigate urban pollution.
Physiological studies and transcriptomic analysis reveal the mechanism of saline–alkali stress resistance of Malus sieversii f. niedzwetzkyan
Authors: Jiang Lepu , Yang Yan , Yu Lei , Zhou Zhengli , Xu Tongyao , Wang Tong , Zhao Jianwen , Chen Xuesen , Wang Shaohua 
Published: January 2024

Abstract

Apple (Malus) is one of the world’s most economically significant fruit varieties. The inability of apple trees to tolerate saline–alkali soil has long limited their growth and yield. Malus sieversii f. niedzwetzkyan is a wild species capable of growing on saline–alkali soil in Xinjiang.Here, we conducted a hydroponic experiment in which M. niedzwetzkyana and M. domestica “Royal Gala” seedlings were subjected to 150 mM saline–alkali stress. Physiological data indicated that the saline–alkali resistance of M. niedzwetzkyana was higher than that of M. “Royal Gala,” as the concentrations of ROS were lower and Na+/K+ ratios were higher in M. niedzwetzkyana than in M. “Royal Gala” under saline–alkali stress. Transcriptome analysis was conducted on the leaves and roots of M. niedzwetzkyana at different time points under saline–alkali stress (0 h, 6 h, and 12 h). A total of 599 differentially co-expressed genes associated with saline–alkali stress were identified. GO and KEGG pathway analysis revealed that DEGs in the leaves were enriched in glutathione metabolism, hydrolase activity, and heme binding following exposure to saline–alkali stress. However, DEGs in the roots were enriched in phenylpropanoid biosynthesis, flavonoid biosynthesis and iron ion binding. We identified hub genes related to superoxide dismutase and Na+, K+ transport using weighted gene co-expression network analysis.Our findings provided new insights into the saline–alkali tolerance of M. niedzwetzkyana at the physiological and molecular levels. this research provides an important genetic resource for identifying genes involved in responses to saline–alkali stress.
Patterns and trends of antimicrobial resistance in bacterial isolates from urine cultures in Eritrea, 2010–2021: a secondary dataset analysis
Authors: Garoy Eyob Yohannes , Ghebrehiwet Matiwos Araya , Fessehaye Nahom , Achila Oliver Okoth , Gebrehiwet Ghirmay Yemane , Abraham Feven Gebremeskel , Berhe Sador Daniel , Berhe Yonatan Laine , Mengistu Samuel Tekle , Buthuamlak Abrehet Marikos , Syum Biniam Efrem , Hamida Mohammed Elfatih 
Published: January 2024

Abstract
Background: Although the threat posed by antibacterial resistance (AMR) in urinary tract infections (UTI) is well documented; significant knowledge gaps remain for most countries in sub-Saharan Africa. In this study, we set out to describe the most common uropathogens in Eritrea. The magnitude, trends, and factors associated with AMR and MDR were also assed.
Methods: A retrospective record review of data (January 2010 - 2021) collected from all urine samples from patients from multiple treatment centers in Eritrea and analysed at the microbiology department at the National Reference Laboratory (NHL) was undertaken. Main outcomes included patient characteristics, magnitude of AMR, MDR, and associated patterns and trends. SPSS was used for statistical analysis, and Microsoft Excel was used to plot figures.
Results: Our analysis indicates that 64.9% (1940) of the patients were male; median age (IQR) was 50 years (35-58 years); and > 50% of the age range of patients were in the 36 to 65 year age band. Antibiotic susceptibility was stable over time except for ciprofloxacin (96% in 2004, 97% in 2009, and 94% in 2014; P < 0.05). With decreasing frequency, the most common isolates were UPEC (39.7%, n=1,190); Kliebsiella spp. (10.7%, n=322), Citrobacter spp. (8.7%, n=260), Enterobacter spp.(7.1%, n=213), Proteus spp. (7%, n=209), Streptococcus Group D (6.5%, n=194) and Pseudomonas aeruginosa(6.4%, n=193). The prevalence of AMR in UTI is high with a strong involvement of ESKAPE organisms. A high proportion (2414 (80.5%)) of MDR (and potentially uropathogens from XDR and PDR) was also reported. Furthermore, a MAR index > - 2 in GNB was obtained in 81.1% of the isolates. Although age and the presence of indwelling devices were significantly associated with the probability of MDR in the aPR; the relationship was attenuated in the uPR. Finally, only sex (higher in males: uPR: 2.97) and isolates of a specific genus were associated with MDR. Compared to UPEC, the probability of MDR followed the following sequence: Pseudomonas aeruginosa > (uPR: 16.9) > Proteus spp. (uPR: 5.2) > other GNBs (uPR: 2.1) > Citrobacter spp (uPR: 1.67). Interestingly, all GPBs (S. aureus, Streptococcus group D) had a reduced likelihood of MDR.
Conclusion: We identified a high and increasing prevalence of AMR and MDR in patients with UTI in Eritrea. The findings emphasize the urgent need to address gaps in laboratory infrastructure, AST testing strategies, AMR surveillance, infection control, reporting, and the use of locally generated data to optimize treatment guidelines.