bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of social media after bereavement by suicide: results from a French online survey
Authors: LEAUNE Edouard , ROUZE Héloïse , LESTIENNE Laurène , BISLIMI Kushtrim , MORGIEVE Margot , CHALANCON Benoit , LAU-TAÏ Pauline , VAIVA Guillaume , GRANDGENEVRE Pierre , HAESEBAERT Julie , POULET Emmanuel 
Published: January 2024

Abstract

Background
According to recent research, the Internet and social media are shaping and changing how we die and mourn. However, the use of social media after bereavement by suicide remains poorly understood. Thus, emerging research is needed to better assess the role that social media can play after bereavement by suicide. The objective of our study was to assess the use of social media in French people bereaved by suicide and to collect their expectations toward social media.
Method
We conducted a national cross-sectional online survey including French people bereaved by suicide assessing their use of social media after the death of their relative. All adults bereaved by suicide were eligible to participate in the study. An online 26-item questionnaire collected sociodemographic and loss-related characteristics and evaluated four dimensions: 1) the use of social media in daily life, 2) the perceived needs regarding suicide bereavement, 3) the use of social media associated with the suicide loss, and 4) the expectations regarding the development of an online resource for people bereaved by suicide and personal propositions regarding the development of such a resource.
Results
Among 401 participants, 61.6% reported using social media after the death of their relative by suicide, especially those recently bereaved, those receiving counseling and bereaved parents. The participants mainly used social media to reach peers bereaved by suicide and to memorialize, while they expected social media to help them finding information on suicide and accessing bereaved peers. Younger participants were more prone to use social media to memorialize, while bereaved partners and those bereaved by the suicide of a parent were less prone to use them with such aim.
Discussion
A large part of people bereaved by suicide use social media for their grief process, mainly to contact peers bereaved by suicide and to memorialize their loved one. According to or results, social media contribute to contemporary grief processes after suicide bereavement and can be seen as putative means to improve the well-being of people bereaved by suicide.
Impact of Body Image Perception on Behavioral Outcomes in Chinese Adolescent and Young Adult Survivors of Sarcoma
Authors: Wei Yihui , Ma Chung Tin , Li Michael Can Heng , Zhou Keary Rui , Loong Herbert Ho Fung , Wong Kwok Chuen , Li Chi Kong , Cheung Yin Ting 
Published: January 2024

Abstract
Purpose
To identify the prevalence and predictive factors of body image dissatisfaction among Chinese adolescent and young adult (AYA) survivors of sarcoma, and to evaluate its associations with behavioral outcomes.
Methods
In total, 116 AYA survivors (48.3% female; mean age 28.2 years, SD = 8.2 years) of osteosarcoma (49.1%) or soft-tissue sarcoma (50.9%) were recruited from an academic hospital. The survivors self-reported their perceived body image using the Body Image Scale. Behavioral outcomes were assessed using DSM-oriented scales of the ASEBA Adult Self-Report checklist. Multivariable linear regression was conducted to identify predictors of body image perception and investigate the association between body image dissatisfaction and behavioral outcomes.
Results
At 15 years post-cancer diagnosis, one third of the cohort (35.3%) reported dissatisfaction with their body image. Female survivors (Est = 3.13, SE = 1.53; P = 0.044) and survivors who had undergone surgery (Est = 7.13, SE = 3.35; P = 0.037) reported poorer body image perception. Body image dissatisfaction was associated with symptoms of depression (Est = 0.29, SE = 0.10; P = 0.005) and avoidant personality (Est = 0.41, SE = 0.12; P < 0.001).
Conclusion
A negative perception of body image was associated with psychological distress in long-term survivorship. The provision of psychosocial intervention early during the cancer care continuum may mitigate the negative impact of body image distress in AYA survivors.
MiR26a Reverses Enzalutamide Resistance in a Bone-Tumor Targeted System with an Enhanced Effect on Bone Metastatic CRPC
Authors: Wang Yuanyuan , Chen Jiyuan , Gong Luyao , Wang Yunxia , Siltari Aino , Lou Yan-Ru , Murtola Teemu J. , Gao Shen , Gao Yuan 
Published: January 2024

Abstract
Resistance to androgen receptor (AR) inhibitors including enzalutamide (ENZ) as well as bone metastasis are major challenges for castration-resistant prostate cancer (CRPC) treatment. In this study, we identified that miR26a can restore the Enz sensitivity and inhibit bone metastatic CRPC. To achieve the highest combination effect of miR26a and Enz, we developed a cancer-targeted nano-system (Bm@PT/Enz-miR26a) using bone marrow mesenchymal stem cell (BMSC) membrane and T140 peptide to co-deliver Enz and miR26a. The in vitro/in vivo results demonstrated that miR26a can reverse Enz resistance and synergistically shrink tumor growth, invasion, and metastasis (especially secondary metastasis) in both subcutaneous and bone metastatic CRPC mouse models. We also found that EZH2/SFRP1/WNT5A axis may in involved in this role. These findings open new avenues for the treatment of bone metastatic and Enz resistant CRPC.
Reduction of cerebral lactate level is correlated with increased Aβ quantity in Alzheimer’s disease model mice
Authors: Zhang Mao , Wang Yanyan , Guan Xingying , Chen Xuedan , Guo Hong 
Published: January 2024

Abstract

Lactate provides signals that modulate neural functions, including excitability, plasticity and memory consolidation. G-protein-coupled receptor 81 (GPR81) is a specific receptor of lactate, which functions in signaling regulation in neural activity. This process is mediated by downstream of GPR81, phosphatidylinositol 3 kinase /protein kinase B/cyclic adenosine monophosphate response element binding protein (PI3K/Akt/CREB) pathway. Previously, it is recognized that lactate content is reduced in the brain of Alzheimer’s disease (AD) model mice. But, it hasn’t been identified whether lactate decrease is related with increased amyloid beta (Aβ) in AD model mice. This work proves that reduced lactate content is correlated with Aβ increase in cortex and hippocampus of AD model mice. Importantly, it signifies that reduced lactate and GPR81 lead to decrease of deoxyribonucleic acid methyltransferase 1 (DNMT1). DNMT1 reduction promotes beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) expression, further increasing Aβ level. Besides, lactate reduction is correlated with decreased expressions of p-PI3K, p-AKT and p-CREB. But, promotion of lactate content activates GPR81-PI3K/Akt/CREB signaling pathway. Hence, it signifies that lactate decrease might contribute to Aβ increase, and underlying mechanism is that reduced lactate induces inhibition of GPR81-PI3K/Akt/CREB pathway, and then decreases DNMT1, increases BACE1 and Aβ levels (Graphic abstract).
The effects of lever positioning manipulation versus schorth exercise in idiopathic scoliosis: a protocol for a randomized clinical trial (RCT)
Authors: Wei Zicheng , Wang Kaizheng , Zhou Xingchen , Chen Longhao , Wu Shuang , Hua Zihan , Xia Qiong , Li Tao , Huang Yuanshen , Lv Lijiang , Lv Zhizhen 
Published: January 2024

Abstract

Background:Idiopathic scoliosis is a prevalent clinical condition within the bone and joint system, commonly manifested in adolescents, significantly impacting their physical and mental well-being. Presently, conservative interventions constitute the primary therapeutic approach, encompassing modalities such as brace therapy, manipulation therapy, and exercise therapy. Nonetheless, challenges persist in the realm of conservative treatment, marked by issues of inconvenience and suboptimal adherence. This study endeavors to identify a manipulation technique that can potentially substitute or augment the efficacy of brace therapy or exercise therapy. The primary objective of this protocol is to delineate a randomized controlled trial aimed at scrutinizing and contrasting the outcomes resulting from a specific manipulation method (lever positioning manipulation) and a widely employed exercise therapy (Schroth exercise) in the management of idiopathic scoliosis.Methods：This is a randomized clinical trial, employing both assessor-blinding and analyst-blinding methodologies. This study is proposed to include 102 patients with idiopathic scoliosis. The 102 patients were divided into 2 groups of 51 cases each by randomized number table method. The groups consist of a traditional massage combined with lever positioning manipulation group and a traditional massage combined with Schroth exercise group. Each exercise regimen is administered thrice weekly over an 8-week duration. Outcome measures encompass the assessment of Cobb angle, apical vertebral translation (AVT), muscle tone, pressure pain threshold (PPT), quality of life (SF-36), Oswestry disability index (ODI) and clinical efficiency. Evaluations are conducted at baseline, the conclusion of the treatment program, and during follow-up sessions. It will be observed whether the manipulation is superior compared to the schorth exercise and whether it can be used as an alternative treatment for scoliosis.Discussion:The results of this study will tell clinicians what conservative therapy regimen will produce better clinical outcomes for patients with AIS.Trial registration:This project is registered with the Chinese Clinical Trial Registry，Registration number:ChiCTR2300077604.
Mean Nutrient Adequacy Ratio of Complementary Foods and Its Associated Factors among Children Aged 6–23 Months in Northeast Ethiopia: A Linear Regression Analysis
Authors: Kassaw Abdulkerim , Mekonen Tefera Chane , Tadesse Erkihun , ABeje Eyob Tilahun , Daba Chala , Tsega Yawkal , Endawkie Abel 
Published: January 2024

Abstract
Background: Inadequate intake of macro and micronutrients is a significant public health challenge in many developing countries, including Ethiopia. Ethiopia carries a substantial burden of both macro and micronutrient deficiencies, with far-reaching consequences. However, there is limited evidence on the determinants and responses to the nutrient adequacy of complementary foods among children aged 6–23 months. Therefore, the aim of this study is to determine the mean nutrient adequacy ratio and associated factors of complementary feeding among children aged 6–23 months in Northeast Ethiopia
Methods: A study was conducted in Northeast Ethiopia between March 01 and April 30, 2023, to determine the nutrient adequacy ratio of complementary feeding among children aged 6–23 months. The study employed a systematic sampling technique to select 255 children. Linear regression analysis was conducted to identify factors associated with the nutrient adequacy of complementary foods. In the multivariable analysis, variables with P–Values of less than 0.05 were considered statistically significant.
Results: The study found that the mean nutrient adequacy ratio of complementary foods among children aged 6–23 months in Northeast Ethiopia was 63% [95% CI (60.8, 65.14)]. The adequacy of nutrients in complementary foods varied, with energy (90%), fat (93%), carbohydrate (70%), protein (88%), calcium (57%), zinc (52%), Vitamin B1 (50%), Vitamin A (52%), and Vitamin C (60%).The age of child, mother’s education, wealth index, feeding frequency, dietary diversity, minimum acceptable diet, source of information during ANC follow-up, PNC follow-up, food insecurity, and the number of under-five children were significantly associated with MAR of complementary feeding.
Conclusions: The study found that the mean adequacy ratio of complementary food among children aged 6–23 months in Northeast Ethiopia was low and fell below the recommendations of the World Health Organization. The factors significantly influenced the MAR of complementary feeding, including age of child, mother’s education, food insecurity, wealth index, minimum dietary diversity, and feeding frequency, minimum acceptable diet, number of children, and ANC and PNC. The findings highlight the need for organized efforts at all levels to enhance the consumption of high-quality diets from locally available foods.
Prevalence and microhabit preference of Hyalomma dromedarii infesting camel (Camelus dromedarius)
Authors: Ibrahim Mohamed 
Published: January 2024

Abstract
Background and Aim:
Hyalomma dromedarii is hematophagous ectoparasites and can transmit viruses and it is a vector of protozoan diseases such as theileriosis in camels, and bacterial diseases such as Q fever and spotted fever rickettsia. This study was conducted to evaluate infestation prevalence, abundance, intensity, and microhabitat of H. dromedarii on camels.
Materials and Methods
This study was conducted in Al Baha area, Saudi Arabia from April 2022 to March 2023. A total of 120 adult camels (Camelus dromedarius) were randomly selected. Ticks were morphologically identified under a stereomicroscope using available taxonomic keys.
Results
The overall infestation prevalence of H. dromedarii was (63.33%). The range of tick load in infested camels were 5–35 ticks/camel. The overall mean abundance and mean intensity of H. dromedarii were (13.29 ± 12.66) and (21.27 ± 9.27) respectively. The number of male ticks was higher than the number of female ticks. The sex proportion of male and female was 67.95% and 32.05% for male and female respectively. The infestation prevalence of H. dromedarii was at its highest rate during the summer (90%), whereas winter had the lowest infestation rate (26.67%). The mean infestation abundance and mean infestation intensity of H. dromedarii varied significantly per season. Positive associations were found between infestation parameters of H. dromedarii and temperature, precipitation / rainfall, and humidity. The tail area had the highest prevalence (63.33%), and mean abundance of tick (6.45 ± 6.03 ticks/host). A combination of chemical control and manual tick removal was used for tick management by farm owners. Moreover, a combination of external and internal chemical control for parasites for camel was recorded.
Conclusion
The current study showed that H. dromedarii ticks had a high prevalence on the camels. No study has been conducted to examine the acaricide resistance status in the country. As a result, future study should investigate and track resistance in tick populations and further epidemiological and molecular studies should be carried out to monitor the distribution of tick species and tick-borne diseases to prevent threats to human health and animal.
Exploring Heliconia chloroplast genomic features through assembly and analysis of four complete chloroplast genomes
Authors: Cheng Xin , Yang Ting , Shi Chengcheng , Liu Xin 
Published: January 2024

Abstract
Background
In the field of Heliconia phylogeny, the analysis has traditionally relied on the use of partially conserved chloroplast and nuclear genes, which serve as important markers for studying coevolution. However, the lack of complete chloroplast genomes for Heliconia species has posed a challenge in achieving a more comprehensive understanding of Heliconia chloroplast genomes and developing specific molecular markers for conducting in-depth phylogenetic studies within the genus.
Results
In this study, we performed sequencing and assembly of the complete chloroplast genomes of four representative Heliconia species of the Zingiberales order: Heliconia bihai, Heliconia caribaea, Heliconia orthotricha, and Heliconia tortuosa. The chloroplast genomes of these Heliconia species exhibited the typical quadripartite structure and ranged in length from 161,680 bp to 161,913 bp, all containing 86 protein-coding genes. Comparative analysis between the Heliconia chloroplast genomes and those of Zingiberales species revealed a high overall similarity in chloroplast genome structure. However, we observed significant variability in the single-copy (SC) regions and noticed a high degree of A/T base preference. Additionally, there were variable amplifications in the inverted repeat (IR) regions. While no genes with high nucleotide diversity were identified, three positively selected genes in Heliconiaceae, including ndhD, rpl2 and ycf2, were discovered when compared to other Zingiberales plants. Moreover, phylogenetic analysis provided strong support for the formation of a monophyletic clade consisting of Heliconiaceae species. This clade was nested within the tribe Heliconiaceae of the Zingiberales order, with high bootstrap support, reinforcing their evolutionary relatedness.
Conclusions
The results of this study have offered insights into the chloroplast genomes of Heliconia, and the dataset produced by our research serves as a valuable resource for subsequent studies on the Heliconia evolutionary trajectory.
Effect of nerve intervention combined with intravenous thrombolysis on the vascular recanalization rate in patients with acute ischemic stroke
Authors: Lei Yancheng , Hou Qian , Wang Jinpeng , Zhang Hao , Lin Cunshan , Zhang Pinyuan 
Published: January 2024

Abstract

Objective
To investigate the effect of nerve intervention combined with intravenous thrombolysis on the rate of vascular revascularization in patients with acute ischemic stroke.
Methods
The clinical data of 118 patients with acute ischemic stroke admitted to our hospital from January 2020 to March 2021 were retrospectively analyzed, and the enrolled patients were divided into a control group and an observation group. The control group received intravenous thrombolysis, and the observation group received neurological intervention based on intravenous thrombolysis. The clinical efficacy and vascular recanalization were compared between two groups after six months of treatment.
Results
After six months of treatment, the total effective rate (94.92%, 56/59) and complete recurrence rate (62.71%, 37/59) in the observation group were significantly higher than in the control group. Before treatment, there were no significant differences between the two groups' peak systolic flow velocity and neurological loss (P > 0.05). After six months of treatment, the vertebral artery systolic peak flow velocity, basilar artery systolic peak flow velocity, and the total incidence of adverse reactions in the observation group were significantly lower than those in the control group (P < 0.05).
Conclusion
The therapeutic effect of nerve intervention on patients with acute ischemic stroke is superior to that of intravenous thrombolysis alone and can effectively improve the rate of vascular revascularization, promote cerebral blood circulation, and reduce the adverse reactions induced by intravenous thrombolysis. It is safe and worthy of clinical application in the future.
Comparison of the incidence of intrathoracic stomach in Bochdalek's hernia detected by imaging with that detected by surgery
Authors: Pan Xiao-Zhu , Feng Chuan , Gao Si-Jie , Huang Xin-Yan , Song Yan 
Published: January 2024

Abstract
Objective:This study investigates the role of preoperative imaging in predicting cases of the intrathoracic stomach in patients with left sided Bochdalek hernia (BH) compared to their postoperative surgical diagnosis.
Methods: A retrospective review was conducted of all left sided BH patients treated at the Children’s Hospital of Chongqing Medical University from Jan 2012 to Dec 2021. According to the time of clinical symptoms, all cases divided into neonatal BH and late onset BH.The number of intrathoracic stomach cases identified on imaging and during surgery were statistically analyzed separately, and the ratio of preoperative imaging to postoperative surgical diagnosis was compared.Meanwhile, the ratio was analyzed separately for neonatal BH and late-onset BH.
Results: A total of 108 patients were identified with left sided BH. The imaging analysis (39/108,36.1%) diagnosed a significantly lower proportion of patients with intrathoracic stomachs as compared to the surgical data (55/108,50.93%) (p = 0.027). The difference was even more apparent in the female patients (P=0.01).For both the neonatal and late onset left sided BH groups, a third of the patients were determined as intrathoracic stomachs by preoperative imaging.
Conclusion: The proportion of intrathoracic stomach (gastric positioning) in left sided BHpatients detected by preoperative imaging was low in comparison to the postoperative data.One third of late onset BHs are confirmed by preoperative imaging examination as intrathoracic stomach, and these patients are more likely to develop severe symptoms
Administration of Oxytocin Receptor Antagonist during Frozen Embryo Transfer: Potential Improvement in Live Birth Rates for Women with Recurrent Implantation Failure, Adenomyosis, and Myoma
Authors: Lin Po-Wen , Chern Chyi-Uei , Li Chia-Jung , Lin Pei-Hsuan , Chen Yu-Chen , Tsui Kuan-Hao , Lin Li-Te 
Published: January 2024

Abstract
Background
The primary objective of this investigation was to assess the potential improvement in pregnancy outcomes among infertile women undergoing in vitro fertilization (IVF) cycles, specifically during frozen embryo transfer (FET), following the administration of an oxytocin receptor antagonist. This study aimed to examine this impact across various subgroups, including individuals experiencing recurrent implantation failure (RIF), adenomyosis, and myoma.
Methods
This retrospective cohort study involved 431 patients who underwent their initial IVF-FET cycle at our reproductive center between January and December 2021. The study group (n = 162) received an oxytocin receptor antagonist during FET, while the control group (n = 227) underwent FET without this antagonist. A comparative analysis of baseline and cycle characteristics was conducted between the two groups, with additional subgroup analyses.
Results
There were no significant differences in baseline or cycle characteristics between the study and control groups. Overall, there was no significant difference in live birth rate between the two groups. However, in specific subgroups, the study group demonstrated significantly greater live birth rates than did the control group for patients with RIF (43.9% vs. 26.2%, P = 0.016), adenomyosis (37.7% vs. 22.1%, P = 0.039), or myoma (46.3% vs. 20.4%, P = 0.004). Multivariate analysis indicated a positive association between oxytocin receptor antagonist use and live birth rates in women with RIF (adjusted OR 2.17, 95% CI 1.08–4.35; P = 0.030), adenomyosis (adjusted OR 3.44, 95% CI 1.43–8.28; P = 0.006), and myoma (adjusted OR 3.11, 95% CI 1.23–7.85; P = 0.016).
Conclusions
While the administration of an oxytocin receptor antagonist during FET did not increase live birth rates in the overall population, it exhibited potential benefits in improving live birth rates in women with RIF, adenomyosis, or myoma.