bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric Properties and Validity of Inventory of Symptoms of Professional Traumatic Grief and Relevance to Clinical Practice.
Authors: Gilart Ester , Bocchino Anna , Lepiani Isabel , Gilart Patricia , Nuñez Maria José Cantizano , Dueñas María 
Published: February 2024

Abstract
Background
Traumatic grief can exert a considerable influence on the mental and physical well-being of nurses, potentially altering their ability to provide high quality care. This impact is most pronounced in specific contexts such as health emergencies, palliative care and paediatric intensive care units. In the context of the Covid-19 pandemic, health professionals have faced an unprecedented increase in loss and trauma, and this situation is seen as an exacerbating factor in complicated bereavement. Despite the availability of instruments for the assessment of prolonged or pathological grief, there is a pressing need for additional studies that allow for a more accurate understanding and measurement of this phenomenon, filling certain existing methodological gaps. The main purpose of this research is to evaluate the psychometric properties of the Inventory of Symptoms of Professional Traumatic Grief (ISDUTYP), with a view to improving assessment tools in this field.
Method
Construct validity, reliability, criterion validity, convergent validity and discriminant validity were assessed. The scale's psychometric properties were tested with 930 nursing professionals. The data were collected between September 2022 and January 2023.
Results
A total of 930 people took part in the study. The factorial analysis of ISDUTYP showed that, according to eigenvalues and the scree plot, the optimal number of factors was 2. These factors consisted of 13 and 12 items, respectively, and had clinical significance. Factor 1 could be termed "Behavioural Symptoms," while Factor 2 could be termed "Emotional Symptoms." Cronbach's alpha values demonstrated excellent reliability for all scores. In particular, Cronbach's alpha was 0.964 for the overall score, 0.950 for the behavioural symptoms subscale, and 0.950 for the emotional symptoms subscale. Regarding criterion validity, all expected correlations were statistically significant. Finally, almost all hypotheses defined of convergent and discriminant validity were fulfilled.
Conclusions
The high reliability and validity of the scale supports its use in research and clinical practice to assess the impact of professional traumatic grief and enhance its treatment. The validated scale for measuring nurses' grief has significant implications in clinical practice, allowing for the identification and management of nurses' grief, fostering a healthy work environment, and improving patient care quality.
Mitochondrial DNA in bronchoalveolar lavage fluid is associated with the prognosis of idiopathic pulmonary fibrosis: a cohort study
Authors: Fukihara Jun , Sakamoto Koji , Ikeyama Yoshiki , Furukawa Taiki , Teramachi Ryo , Kataoka Kensuke , Kondoh Yasuhiro , Hashimoto Naozumi , Ishii Makoto 
Published: February 2024

Abstract

Background
Extracellular mitochondrial DNA (mtDNA) is released from damaged cells and increases in the serum and bronchoalveolar lavage fluid (BALF) of idiopathic pulmonary fibrosis (IPF) patients. While increased levels of serum mtDNA have been reported to be linked to disease progression and the future development of acute exacerbation (AE) of IPF (AE-IPF), the clinical significance of mtDNA in BALF (BALF-mtDNA) remains unclear. We investigated the relationships between BALF-mtDNA levels and other clinical variables and prognosis in IPF.
Methods
Extracellular mtDNA levels in BALF samples collected from IPF patients were determined using droplet-digital PCR. Levels of extracellular nucleolar DNA in BALF (BALF-nucDNA) were also determined as a marker for simple cell collapse. Patient characteristics and survival information were retrospectively reviewed.
Results
mtDNA levels in serum and BALF did not correlate with each other. In 27 patients with paired BALF samples obtained in a stable state and at the time of AE diagnosis, BALF-mtDNA levels were significantly increased at the time of AE. Elevated BALF-mtDNA levels were associated with inflammation or disordered pulmonary function in a stable state (n = 90), while being associated with age and BALF-neutrophils at the time of AE (n = 38). BALF-mtDNA ≥ 4234.3 copies/µL in a stable state (median survival time (MST): 42.4 vs. 79.6 months, p < 0.001) and ≥ 11194.3 copies/µL at the time of AE (MST: 2.6 vs. 20.0 months, p = 0.03) were associated with shorter survival after BALF collection, even after adjusting for other known prognostic factors. On the other hand, BALF-nucDNA showed different trends in correlation with other clinical variables and did not show any significant association with survival time.
Conclusions
Elevated BALF-mtDNA was associated with a poor prognosis in both IPF and AE-IPF. Of note, at the time of AE, it sharply distinguished survivors from non-survivors. Given the trends shown by analyses for BALF-nucDNA, the elevation of BALF-mtDNA might not simply reflect the impact of cell collapse. Further studies are required to explore the underlying mechanisms and clinical applications of BALF-mtDNA in IPF.
Helminth Fauna of the Yellow-bellied Toad, Bombina variegata (Linnaeus, 1758) Collected From Northwestern of Türkiye
Authors: YILDIRIMHAN Hikmet Sami , SÜMER Nurhan , REDHWAN Adel Mohammed , BÜLBÜL Ufuk , KARIŞ Mert , Civil Yeliz , DIRSHE Mohamed Warsame 
Published: February 2024

Abstract
In this study, 45 individuals (18 female, 20 male, and 7 juvenile) of the Yellow-bellied Toad, Bombina variegata were collected from Karacahasan Mountain region (located in the Enez district of Edirne province in northwestern Türkiye) in 2015–2016 and examined for helminths. Two species of Digenea (Gorgodera cygnoides and Pleurogenoides medians) and one species of Acanthocephala (Acanthocephalus ranae) were found. This study is the first helminth study and only helminth study conducted on B. variegata from Türkiye.
Mapping the current trends and hotspots on depression comorbid with insomnia: A bibliometric analysis
Authors: Jia Zhixia , Yu Wenyan , Dong Tiantian , Li Xuhao , Wang Xingxin , Yang Jiguo , Liu Yuanxiang 
Published: February 2024

Abstract
Background
Depression and insomnia often co-occur and have a bidirectional relationship. This review utilized bibliometric and visualized analysis to explore current research hotspots and trends in this field to identify future clinical practice directions.
Methods
To identify papers on the comorbidity of depression and insomnia, the researchers utilized the Web of Science Core Collection (WoSCC). They employed tools such as CiteSpace, VOSviewer, and Scimago Graphica to visually analyze the knowledge network of authors, institutions, countries/regions, journals, cited authors, cited references, cited journals, and keywords in the field of depression comorbid with insomnia.
Results
A total of 697 papers were extracted from the Web of Science Core Collection (WoSCC) with Andrew D. Krystal being the most influential author in this area. The University of Pittsburgh and the United States emerged as the most prolific institution and country, respectively. The Journal of Affective Disorders was the most productive journal, with primary keywords including insomnia, depression, anxiety, disorder, and sleep. In terms of co-citation analysis, Morin, Cm led the field. The top-cited journal was Sleep, and the paper titled “Validation of the Insomnia Severity Index as an outcome measure for insomnia research” ranked first. Finally, “Psychiatry”was the most frequent study category.
Conclusions
This bibliometric analysis provides a comprehensive overview of current research on depression comorbid with insomnia and highlights key areas of focus, offering guidance for clinicians and researchers in selecting research directions.
Investigation of the impact of surface heterogeneity on the surface energy balance non-closure using long-term observations
Authors: Jomé Mathilde , Lohou Fabienne , Lothon Marie , Canut Guylaine , Brut Aurore , Derrien Solène , Vial Antoine , Tallec Tiphaine 
Published: February 2024

Abstract

Recent studies highlighted that the modelling of surface fluxes of momentum, sensible and latent heat is the second most important issue in the weather and climate numerical models. Eddy-covariance measurements are used to implement and validate those models, but one systematic error is identified and makes the comparison between models and observations tricky : the Energy Balance Non-Closure (EBNC). A one-year field experiment is performed in Toulouse, south-west of France, to document the variability of the land-atmosphere exchanges around the Météopole permanent site. Three indicators that aim to quantify the surface and fluxes heterogeneity are defined and applied to several domain sizes (footprint scale, 1-km-scale and 10-km-scale analysis). They are cross-analysed with the EBNC to investigate the impact of the surface heterogeneity on the non-closure. The results showed that while no systematic nor strong relationship was found, the footprint-scale analysis and the sensible heat flux studies at a 1-km and 10-km-scale seem to have a tendency to match with the variations of the EBNC. By extending the studied domain from 1 km to 10 km, we incorporate a greater heterogeneity in latent heat flux than in sensible heat flux. The impact of the organisation of the surface was studied through an indicator based on the length scale of the surface patches. The results did not suggest fundamentally different outcomes but they did highlight the differences between the 1-km and the 10-km scales, and between the sensible and latent heat flux analysis.
The Protective Effect of Hyperin on H2O2 induced Injury of Ovarian Granulosa Cell in Mice
Authors: liu Min , An Caiping , Qin Lu , Hang Hang , Tang Minjie 
Published: February 2024

Abstract
Objective
To investigate the protective effect and mechanism of hyperin on hydrogen peroxide (H2O2)-induced injury of granulosa cells in mice.
Methods
Adult female BALB/c mice were randomly divided into control group, POI model group and hyperin treatment group. The primary mice ovarian granulosa cells were extracted, cultured in vitro, and exposed to H2O2 to establish the oxidative damage model of ovarian granulosa cells. The ovarian granulosa cells were added with different concentration hyperin (0µg/l, 5µg/l, 10µg/l, 25µg/l, 50µg/l, 75µg/l respectively); and observed the proliferation under different hyperin concentration. The concentration level with the most significant proliferation would be selected for treatment group. Serum estradiol(E2), follicle-stimulating hormone(FSH), anti-mullerian hormone(AMH), superoxide dismutase(SOD) and catalase(CAT) were measured by ELISA.The mRNA and protein levels of nuclear factor (erythroid-derived 2)-related factor 2(Nrf-2), heme oxygenase-1 (HO-1), Caspase3, Bcl-2 and Bax in ovarian granulosa cells were measured by RT-qPCR and Western blot. The protein levels of phosphorylated phosphatidylinositol 3-hydroxy kinase (p-PI3K) and phosphorylated protein kinase B (p-Akt) were measured by Western blot. The reactive oxygen species (ROS) levels in granulosa cells were determined by H2DCFDA. The apoptosis of granulosa cells was examined by TUNEL assay.
Results
50µg/l hyperin has the most significant effect on proliferation of ovarian granulosa cells. Comparing with the model group, the serum levels of E2, SOD and CAT in Hyperin treatment group increased (P < 0.05).The expression of Nrf-2, HO-1, p-PI3K, p-Akt and Bcl-2 in ovarian granulosa cells increased, while the expression of Caspase3 and Bax decreased (P < 0.05). ROS level decreased (P < 0.05). TUNEL assay showed reduced apoptosis of granulosa cells (P < 0.05).
Conclusion
Hyperin can improve H2O2-induced ovarian granulosa cell injury through Nrf-2/HO-1 anti-oxidative stress and PI3K/Akt anti-apoptosis.
A nomogram for predicting choledochal cyst with perforation
Authors: Zhang Guangwei , Wang Haoming , Hu Jianyang , Yang Chenyu , Tan Bingqian , Hu Jiqiang , Zhang Mingman 
Published: February 2024

Abstract

Background Choledochal cyst with perforation (CC with perforation) rarely occurs, early diagnosis and timely treatment plan are crucial for the treatment of CC with perforation. This study aims to forecast the occurrence of CC with perforation.Methods All 1111 patients were conducted, who underwent surgery for choledochal cyst at our hospital from January 2011 to October 2022. We conducted univariate and multivariate logistic regression analysis to screen for independent predictive factors for predicting CC with perforation, upon which established a nomogram. The predictive performance of the nomogram was evaluated using receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA) curves.Results The age of children with choledochal cyst perforation is mainly concentrated between 1 and 3 years old. Logistic regression analysis indicates that age, alanine aminotransferase, glutamyl transpeptidase, C-reactive protein, vomiting, jaundice, abdominal distension, and diarrhea are associated with predicting the occurrence of choledochal cyst perforation. ROC curves, calibration plots, and DCA curve analysis curves demonstrate that the nomogram has great discriminative ability and calibration, as well as significant clinical utility.Conclusion The age of CC with perforation is mainly concentrated between 1–3 years old. A nomogram for predicting the perforation of choledochal cyst was established.
Effectiveness and Tolerability of Rectal Ointment and Suppositories Containing Sucralfate for Hemorrhoidal Symptoms: A Prospective, Observational Study
Authors: Marik Anikó Rita , Miklós Ildikó , Csukly Gábor , Hársfalvi Péter , Novák András 
Published: February 2024

Abstract
BACKGROUND AND AIMS
A high number of topical products are available for the treatment of hemorrhoidal symptoms. Sucralfate-based topical products constitute a new treatment alternative that act as a mechanical barrier to facilitate healing. The aim of this prospective, observational study was to determine patient- and physician-assessed effectiveness and tolerability of rectal ointment and suppositories containing sucralfate for the treatment of hemorrhoidal symptoms in routine clinical practice.
METHODS
Adult patients with diagnosed, mild-to-moderate, symptomatic non-bleeding hemorrhoids treated with rectal ointment or suppositories containing sucralfate in routine clinical practice were enrolled. Patients were administered treatment twice per day for at least 1 week until symptom resolution and/or for a maximum of 4 weeks. The primary endpoint was patient-assessed effectiveness on a modified symptom severity score (mSSS, range 0 to 14). Physician-assessed effectiveness (9 symptoms, 0 to 5 Likert scale), hemorrhoid grade, and patient satisfaction were also determined.
RESULTS
Five investigators enrolled 60 patients; mean age was 48.4±16.6 years and 72.4% were female. Pain or pressure sensitivity was reported as the most severe symptom by patients, and pressure sensitivity, discharge, soiling and prolapse by physicians. Mean patient-assessed mSSS at baseline was 6.6±1.9 and was significantly improved overall and in the ointment and suppository groups individually by -4.6±2.0, -4.4±1.8, and -4.8±2.2, respectively (p<0.0001). Investigator-assessed mean baseline symptom score was 18.1±3.9 and improved by -7.1±4.5, -6.9±5.4, and -7.3 ± 3.5, respectively (p<0.0001). Investigator-assessed symptoms of pressure sensitivity, swelling and discharge were improved to the greatest extent. Hemorrhoid grade was improved in 38% of patients at the end of treatment. Compliance with treatment was 97.4% and patient satisfaction with application and onset of action was high (81.3% and 76.2%, respectively). Both the ointment and suppository were well tolerated.
CONCLUSIONS
The effectiveness of topical ointment or suppository containing sucralfate on patient- and investigator-assessed hemorrhoidal symptoms in real-life clinical practice was demonstrated. Patient satisfaction was high and treatments were well tolerated. Larger controlled trials are warranted to confirm the results.
How does digital economy affect the development of common prosperity level?
Authors: Luo Linhan , Xiong Guangqin 
Published: February 2024

Abstract

Digital economy is not only a new driving force for economic growth, but also a new way to promote common prosperity. This paper examines how digital economy affects common prosperity development in China, using spatial Durbin model and panel data of 30 provinces from 2012 to 2022 to empirically analyze the direct effect, spatial spillover effect, and marginal incremental effect of the digital economy in terms of driving the development of common prosperity. The research results show that the digital economy has a significant positive direct effect and spatial spillover effect on the development of common prosperity, and there is a marginal incremental effect, i.e., the higher the level of the digital economy, the greater the promotion of the development of common prosperity. Plus, total factor productivity enhances the relationship between digital economy and common prosperity. The paper reveals the mechanism and path of digital economy’s impact on common prosperity, and provides theoretical and policy implications for improving digital economy strategy and promoting high-quality development and common prosperity.
Can Generative AI Craft Variable Questions? A Mixed-Method Study on AI’s Capability to Adopt, Adapt, and Create New Scales
Authors: Salah Mohammed , Abdelfattah Fadi , Alhalbusi Hussam , Jassem Suaad , Mohammed Muna , Ismail Maria Mohd , Washahi Maryam Al 
Published: February 2024

Abstract
This study examines the capabilities of Generative artificial intelligence (AI), particularly GPT-4, in transforming research scale development, a process traditionally characterized by extensive time requirements and the potential for human bias. The research aims to clarify whether AI can match and enhance the efficiency and objectivity of research scale creation and adaptation. By adopting a mixed-method design, the study utilizes GPT-4 to generate and modify research scales, which were then rigorously evaluated for reliability and validity and juxtaposed against the scales developed through traditional methodologies. This comprehensive evaluation encompasses quantitative and qualitative assessments and provides a general view of the effectiveness of AI-generated scales. Results revealed GPT-4’s remarkable ability to produce reliable, valid, and comparable research scales that were developed using established methods. Expert feedback further underscores AI’s potential in this field, particularly in reducing human biases and increasing methodological efficiency. A synergistic approach was developed Based on consensus, combining AI’s computational strengths and human oversight and expertise. This study highlights a significant advancement in research methodology and illustrates AI's practical and beneficial integration in scale development. Moreover, it opens new research practice avenues and enables the selection of highly streamlined, unbiased, innovative scale creation processes.
Positioning and Tracking with ODE-LSTM Algorithm for Emerging Smart Rail Systems
Authors: Zhao Xiao , Tian Feng , Shao Ziling 
Published: February 2024

Abstract

In this paper, we propose a NLOS positioning and tracking method in order to be applied in the emerging smart rail systems. By analyzing MIMO scatter channels, the geometric relationship for positioning between each UE, BS and scattering point can be modeled that includes information of AOA, AOD, TOA. The accuracy of positioning can be improved by forming an optimization problem with bias in time and orientation. Further, in order to track the mobile UE, an ODE-LSTM algorithm is proposed, which is combined by ODE derivation solver and LSTM network. It puts the positioning information into an ODE-LSTM network to achieve continuous tracking in arbitrary time instance. Simulation Works validate that the proposed ODE-LSTM method shows better performance in nonlinear tracking than traditional Kalman filter or enhanced Kalman filter.
A dual-targeting approach with anti-IL10R CAR-T cells engineered to release anti-CD33 bispecific antibody in enhancing killing effect on acute myeloid leukemia cells
Authors: Yan Zhifeng , Gu Runxia , Chen Nianci , Zhang Ting , Ma Haotian , Xu Yingxi , Qiu Shaowei , Xing Haiyan , Tang Kejing , Tian Zheng , Rao Qing , Wang Min , Wang Jianxiang 
Published: February 2024

Abstract
Background
The introduction of immunotherapies, such as chimeric antigen receptors (CAR) T cells and bispecific antibodies (BsAbs), has significantly revolutionized the treatment landscape for acute myeloid leukemia (AML). In this study, we developed a dual-targeting approach with anti-IL10R CAR-T cells engineered to release CD33-targeted bispecific antibody to address the major challenges in T cell-directed therapies, including antigen loss and tumor heterogeneity that contribute to relapse.
Methods
T cells were transduced with lentiviral supernatants containing IL10R CAR.CD33 BsAb (CAR.BsAb)-encoding sequence, which incorporated the CD33-targeted bsAb and a second-generation IL10R CAR. The efficacy of the CAR.BsAb-T therapy against AML was evaluated both in vitro by cocultures of CAR.BsAb-T cells with leukemia cell lines or primary AML samples, and in vivo using a xenograft leukemia mouse model.
Results
The study demonstrated the effectiveness of the dual-targeting strategy in eliminating AML cell lines and primary cells expressing varying levels of CD33 and/or IL10R. The secreted anti-CD33 bsAb by IL10R CAR-T cells could amplify the activation and cytotoxicity of both IL10R CAR-T cells and untransduced bystander T cells against CD33 positive leukemia cells. In vivo study further confirmed that CAR.BsAb-T cells could effectively redirect T cells, reduce tumor burden, prolong mice survival, and exhibit no obvious toxicity. This strategy of local bsAbs delivery directly to tumor sites mitigates the pharmacokinetic issues commonly associated with the rapid clearance of bsAbs.
Conclusions
Overall, the engineering of a single construct targeting IL10R CAR, which subsequently secretes CD33-targeted bsAb, addresses the issue of immune escape due to the heterogeneous expression of IL10R and CD33, and are expected to provide better therapeutic effects for AML treatment.
SCS: A Secure Cloud Storage Framework with Enhanced Integrity and Auditability Using Consortium Blockchain System
Authors: Aguru Aswani Devi , Mahadevan RS Rahul , Erukala Suresh Babu , Kaluri Rajesh , Bashir Ali Kashif , Gadekallu Thippa Reddy 
Published: February 2024

Abstract

The widespread use of cloud storage enables users to access their resources remotely via a self-service model. Utilizing pay-per-use storage services provided by cloud service providers (CSPs) requires users to commit financially to their resources. This paper introduces an SCS framework that provides a secure architecture for cloud storage using a consortium blockchain network to solve the trust issue. This framework substitutes the third-party auditor with peers of a consortium blockchain network, which handles the role of data storage and verification. The storage space is segmented between uncommitted and committed storage, where uncommitted storage is designated for storing unverified documents. In contrast, committed storage is designated for the storage of committed documents. Those data documents that have undergone consensus validation by a specified threshold of peer nodes will be transferred to committed storage. The implementation of the SCS framework is carried out on Hyperledger Fabric. The security analysis proves that SCS effectively safeguards cloud storage against devastating attacks while preserving its integrity and auditability. The performance analysis reveals that the metrics for document upload time, document retrieval time, block acceptance time, execution time, and latency are optimal compared to state-of-the-art techniques.