bluuebunny/crossref_metadata_2025_split huggingface dataset:
Professors-Lawyers of Кaterinoslav University (1918)
Authors: Malynovsky B.V. , Malynovska T.V. 
Published: January 2025

The purpose of the research is to consider the process of establishing of Katerinoslav (now Dnipro) University and formation of its first law departments, to make a list the faculties in the first years of its work, as well as to determine the range of scientific interests of lawyers, their studying of legal traditions in Germany. According to the founders’ idea, the university was to complete the educational system of Katerinoslav and Ukraine as a whole, to become one of the main centers of science and culture in the region and in the whole country. It was one of six universities in the Ukrainian State under hetman P. P. Scoropadsky. The proposal to create the university came from the local administration of Katerinoslav. In the city and region It has received a wide public support. The Government of the Ukrainian state actively contributed to the project implementation. This initiative was fully in line with Hetman’s policy. The leaders of the Ukrainian state believed that the solution of the main internal political tasks was to overcome the turmoil caused by the first World War and political crisis of 1917 – early 1918, restoration of law, economic order and mass improvement of welfare. He was assured that the development of the Ukrainian national statehood was impossible without effective measures to support culture. The University consisted of four faculties – physical-mathematical, medical, historical-philological and legal. During the first semester of the starting academic year (September 23 – December 14, 1918), in Law Faculty the following Departments functioned: the Department of the Encyclopedia of Law (Professor O. M. Ladyzhensky), the History of Russian Law Tradition (Professor F. V. Taranovsky was the Dean), the History of Roman Law (Professor K. A. Fleishits), the chair of political economy (Professor O. A. Manuilov), sociology (associate professor S. I. Galperin). The Department of Western Russian (Ukrainian) Law History did not get students and, thus, did not work. The professors of the University belonged to the range of leading specialists of their fields in the former Russian Empire. The greatest authority was F. V. Taranovsky (author of the works on theory and history of law, academician of the hetman government of the Ukrainian Academy of Sciences) and O. A. Manuilov (a well-known economist, former Rector of Moscow University, Minister of Education in the Russian Provisional Government). The sphere of scientific interests of professors of the Faculty of Law of the University of Katerinoslav covered a wide range of problems, including issues related to peculiarities of political and legal development of Germany (role of the German state in international politics, German legal culture, history of German law).
The Mennonites in the period of the “Makhno Republic” (at the end of the 1919)
Authors: Khodchenko O.E. 
Published: January 2025

The article deals with the events of the Ukrainian Revolution of 1919 on the territory of the Right-bank Ukraine, where the Mennonite colonies were compactly located. The purpose of the research is to study the processes and events in the Mennonite colonies of the Right-bank Ukraine during 3-month Makhnovist seizure of the territory, as well as the moral and psychological state of the Mennonite society under the conditions of Makhnovist domination. It is also important to study the battles in the area of Nikopol-Apostolovo –Vorontsovka in November – December, 1919. The Uman breakthrough and the victorious raid on the rear of Denikin’s troops became a milestone in the history of the Ukrainian Revolution. Nestor Makhno and his Insurgent Army rose in popularity with the population of the South of Ukraine so much that electoral prerequisites appeared for creation of political and economic autonomy on the controlled territory. The local peasantry was the only strata to support the Makhnovist formations with unresolved land issue. The Mennonite colonies and colonists were the objects of the peasants` and the Makhnovist troops` attention. For the Makhnovists, the Mennonites were strangers in culture, language and faith, in political sympathies and property status. They were classified as a socially dangerous community, who must be subjected to oppression and expropriation of their farms in favor of Ukrainian peasantry. The attitude of the anarchists towards the Mennonite landowners during the autumn-winter period of 1919 became more cruel, daring and provocative, and the surrounding villagers became more aggressive. In November-December 1919, the peasants of the Ukrainian villages of Sholokhovo, Fedorovka and Shesternya took advantage of the situation. As a result, the Mennonite colonies of Ebenfeld, Steinbach, Eichenfeld and Munsterberg were destroyed, and their property and land were seized in favor of Ukrainian peasants.
Giant Vesical Calculus with Vesico-Vaginal Fistula and Multiple Sewing Needles in the Peritoneal Cavity in a 13 year old Female
Authors: Padmanabha Vijayan 
Published: January 2025

A 13 year old post pubertal nomadic girl came to us with a history of recurrent lower abdominal pain and urinary incontinence of 3 years duration. She also had intermittent hematuria. She also stated that her late (mentally deranged) mother had inserted multiple needles into her (patient’s) vagina when she was 5 years of age. She underwent a successful 2 stage surgical procedure for removal of the needles, calculus and repair of the fistula.
Los sentidos metafóricos de <i>grande </i>y <i>pequeño</i>
Authors: Ynduráin Pardo de Santayana Carlos 
Published: January 2025

The aim of this article is to analyze the semantic values that are usually associated with the Spanish adjectives grande and pequeño beyond their purely dimensional senses (linked, in principle, with the size of the entities of the physical world). In the part dedicated to the lexicographic proposal, these semantic values will be separated and grouped in such a way that, once ordered and defined, they will be shown as possible meanings of a dictionary. Throughout this article, the focus will be on showing the polysemic character of the concerning words and on explaining the cognitive processes that underlie the development of the metaphorical or metonymical senses to which they are usually related. The lexicographical decisions made later on will be related to this first semantic analysis; the aim is to provide coherence to the proposal and to justify, as far as possible, the steps taken in the elaboration of the entries for the words grande and pequeño.
A case of differential diagnosis of REM sleep behavior disorder and sleep-related hypermotor epilepsy
Authors: Kantimirova E. A. , Dmitrenko D. V. 
Published: January 2025

Aim. To describe a clinical case of differential diagnostics of motor phenomena during sleep. Materials and methods. Patient B., 37 years old. Visit to a somnologist at the University Clinic. Complaints were mainly made by the patient’s wife, since the patient himself does not remember these episodes. According to the wife, sudden sweeping movements of the arms and legs, incoherent speech are noted during sleep, then the patient gets up, can grab his hands, behaves aggressively, shifts things. These complaints have been noted for more than 10 years, with a gradual worsening of symptoms. A neurologist at the place of residence suggested a possible epileptic nature of these episodes,but no further examination was carried out. Results. From a semiological point of view, motor phenomena during sleep can imitate epileptic seizures, parasomnias, rapid eye movement behavior disorders, and normal sleep motor phenomena such as fragmentary sleep myoclonus, periodic limb movements, bruxism, etc. A differential diagnostic search is provided, a comparative characteristic of motor phenomena during sleep and wakefulness is given, as well as a scale of frontal epilepsy and parasomnia, which can help the doctor in making the correct diagnosis. Conclusion. Conducting a comprehensive examination of the patient and clarifying the clinical diagnosis made it possible to choose the correct management tactics, avoid unjustified prescription of antiepileptic drugs, and reduce emotional stress in the family due to the ambiguity of the manifestations of night motor phenomena. The established clinical diagnosis allows monitoring the patient in terms of the possible debut of a neurodegenerative disease.
Child with hypocalcaemia: a rare case of HDR syndrome
Authors: George Jewel Maria , Cherian Carol Sara , Philip Rajeev , Sunnychan Sebin 
Published: January 2025

Barakat syndrome (also known as HDR syndrome) is an autosomal dominant disorder characterized by the triad of Hypoparathyroidism (H), nerve Deafness (D) and/or renal disease caused by mutation of the GATA3 gene located at chromosome 10p15. This syndrome is very rare with exact prevalence not known and only few cases are reported in the literature. 4-month-old baby girl, diagnosed as hypoparathyroidism on supplements, presented with seizures due to hypocalcemia. On detailed evaluation, child was found to have bilateral hearing loss. Facial dysmorphisms were noted in the form of bulbous nose with everted nares, long philtrum, thin upper lip, low set ears and bilateral non paralytic convergent squint. External genitalia showed perianal groove with an anteriorly placed anus. Startle response was blunted. Other systemic examination was within normal limits. Routine blood investigations revealed low serum calcium (calcium (total) 4.8 mg/dl) and high serum phosphorous level (11.3 mg/dl). Serum parathormone level was 4.4pg/ml and vitamin D levels were insufficient. Child was managed with IV calcium correction and 1,25 (OH)2 VIT D3. The brainstem evoked response audiometry (BERA) showed severe hearing loss. Next - generation sequencing showed a heterozygous missense variant in exon 4 of the GATA 3 gene which was suggestive of Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome. This case report aims to provide awareness of rare inherited conditions in a patient with abnormal physical and laboratory findings even though their initial presentation was seizure and hypocalcemia.
Retrospective analysis of prognostic determinants of neonatal hearing loss: an Indian experience in a tertiary care hospital
Authors: K. Manoj Kumar , Gujrathi Sagar , Chauhan Indrajeet , Yadav Praveen Kumar , Nayyar S. S. , Sonkar Lekhraj 
Published: January 2025

Background: Childhood hearing impairment is a result of combination of intrauterine environment, perinatal and postnatal factors. The Joint Committee on Infant Hearing (JCIH) has been providing guidelines for early detection of infants with or at risk of hearing loss. In India, UNHSP (Universal neonatal hearing screening program) as a part of NPPCD (National Program for Prevention and Control of Deafness) is a strategy that enables to identify congenital deafness and hearing loss.
Methods: Retrospective cross-sectional study was carried out of a database of newborn hearing screening at a tertiary care hospital of New Delhi, India. The screening results, the risk indicators for hearing loss, diagnosis and the prognosis were descriptively analysed.
Results: 3640 neonates were included in the study between January 2021 and November 2023. It was observed that, of the 25 babies diagnosed with hearing loss the common risk factors were low birth weight with preterm delivery, hyperbilirubinemia, low birth weight, preterm delivery, NICU stay>05 days and syndromes.
Conclusions: UNHSP (Universal Neonatal Hearing Screening Program) aids in early diagnosis of hearing loss using DPOAE (distortion product otoacoustic emission) and BERA (brainstem evoked response audiometry) and significantly reduces the referral rate. Babies with hyperbilirubinemia, preterm delivery and low birth weight have a poor prognosis and are at a higher risk for neonatal hearing loss as per our study. Hearing augmentation in early years of life reduces morbidity and aids better quality of life.
Land Map of Aleksinsky District 1739—1740 as a Source of Information about the Settlements of the Upper Oka River
Authors: Deduk Andrey 
Published: January 2025

The article discusses the problem of attribution of the map of Aleksinsky district. The map is kept in the manuscripts department the Library of the Russian Academy of Sciences. The map was dated in the 1946 inventory to the second half of the 18th century. Journal of surveying a map of Aleksinsky district in 1739—1740. was found in RGADA. The journal is characterized as a historical source. It was possible to establish that in St. Petersburg in 1761, a copy of the map of the Sofonov surveyors was attached to the response to the questionnaire of the land gentry corps. Probably, the map stored in the Library of the Academy of Sciences is a copy of the map attached to the application form. The article analyzes the hillfort shown on the map.
The Two Sides of the Iron Curtain. Professor Mikhail P. Lesnikov and the Displaced Tallin City Archives in Göttingen in the 1950s — 1970s
Authors: Portnykh Valentin 
Published: January 2025

The article is dedicated to Professor Mikhail Pavlovich Lesnikov (1892—1983), specialist in medieval trade, who is known as the publisher of trade books of the merchant Hildebrand Veckinchusen (late 14th — early 15th century). His scientific biography is a clear illustration of how displacements of cultural heritage during the Second World War could have affected scholarly research. In addition, the example of Lesnikov demonstrates how a medievalist, whose subject was far from current political issues, could become an unwitting victim of the political relations between the opposite sides of the Iron Curtain, and personally encounter the “two-sided” nature of the latter.
Structures and Statuses of Polities in the English Intellectual Discourse of the Early 17th Century
Authors: Palamarchuk Anastasia 
Published: January 2025

The article discusses the representation of the genesis, development and structures of complex polities in the treaties of the English intellectuals of the early Seventeenth century. The key notions used by the authors of antiquarian and historical-legal treatises are the following: “empire”, “sovereign kingdom” and “subordinated kingdom” (this term was applied to polities where the title of king remained a feudal dignity). The history of polities of various genesis and status, reconstructed in the treatises of the Early Stuart antiquarians and lawyers, was intended to demonstrate the dynamic nature of these states, which implied a potential change of status in concrete historical conditions.
Poczucie sensu życia i wartości młodzieży. Konteksty psychopedagogiczne
Authors: Opozda Danuta 
Published: January 2025

Artykuł podejmuje problematykę poczucia sensu życia młodzieży. Kolejno omówiono zagadnienie rozumienia sensu życia – jego strukturę, funkcje i podmiotowy charakter. Przedstawiono niektóre kwestie związane z systemem wartości i procesami wartościowania. Zwrócono uwagę na filozoficzną proweniencję omawianych wątków. W dalszej części nawiązano do rozwojowych i wychowawczych aspektów kształtowania poczucia sensu życia młodzieży oraz podano przykładowe wyniki badań nad deklarowanymi przez młodzież wartościami mającymi znaczenie w określaniu sensu własnego życia.
A new approach to assessing the efficacy of anthelmintic agents in vitro
Authors: Perina E. A. , Buyko E. E. , Kaminskiy I. P. , Sobakin D. S. , Ufandeev A. A. , Kaidash O. A. , Ivanov V. V. , Udut E. V. 
Published: January 2025

Aim. To develop a new method to determine the viability of Opisthorchis felineus in vitro using the MTS reagent and to evaluate its applicability for analyzing the efficacy of anthelmintic agents in the treatment of opisthorchiasis.Materials and methods. Golden hamsters were used to create a model of O. felineus infection. The animals were infected with metacercariae obtained from fish of the Cyprinidae family. Three months after infection, adult parasites were extracted from the hepatobiliary system. Their viability was assessed using the motility scale and a new method based on the modified MTS test protocol. To account for differences between the size and number of adult parasite cells, the results were normalized with respect to protein content. To evaluate the feasibility of the new approach in the study of pharmacological activity against opisthorchiasis, the viability of adult parasites in the presence of praziquantel was tested.Results. During incubation of adult flukes in a medium with the addition of the MTS reagent, colored watersoluble formazan was accumulated. Thermal inactivation of parasites significantly decreased the production of this compound. Since the studied adult parasites differed in size and number of cells, the obtained data on their viability were normalized to protein content. The results correlated with the data on parasite viability obtained by the traditional method using the motility scale. Evaluation of praziquantel efficacy at different concentrations using two independent methods (the MTS test and the motility scale) showed that the results of the MTS test were consistent with literature data and comparable with the results obtained using the motility scale.Conclusion. A new method for in vitro evaluation of anti-opisthorchiasis activity of drugs was developed. It is based on the assessment of water-soluble formazan production by adult O. felineus flukes in the culture medium using the MTS reagent for screening anti-opisthorchiasis activity of new anthelmintic drugs.
The use of three-dimensional bioprinting for skin regeneration and wound healing (literature review)
Authors: Barsuk I. A. , Golovko K. P. , Alexandrov V. N. , Khasanov A. R. , Edgeev N. I. , Galiullin R. I. 
Published: January 2025

Three-dimensional (3D) bioprinting is rapidly proliferating across many medical disciplines and is making strides towards manufacturing intricate human organs for clinical application. One of the most promising areas in 3D bioprinting is development of bioinks with certain composition and designed properties.The aim of this systematic review was to assess current biomedical research evidence regarding the efficacy of 3D bioprinting for skin regeneration and wound healing. A comprehensive search for all applicable original articles was conducted according to pre-established eligibility criteria. The study employed PubMed, Web of Science, Scopus, Medline Ovid, and ScienceDirect databases.Of the retrieved articles, eighteen satisfied the inclusion criteria, while twenty-three were excluded. A total of 159 animals that had wound defects were considered in all animal-based research. Collagen and gelatin hydrogels were the most commonly employed bioinks. In relation to cellular composition, allogeneic fibroblasts and keratinocytes were predominant. The observation period ranged from one day to six weeks. Complete wound closure was achieved within 2–4 weeks in most animal studies. In vitro and in vivo animal studies have shown a positive effect of printed bioengineered constructs in accelerating wound healing. Notably, the research where bioprinting was performed directly in the wound in situ was of particular interest. Further studies are required to enhance the tissue bioprinting technique to address skin wound healing in animal models. The utilization of standardized parameters may pave the way for human clinical studies.
Clinical trials on oncolytic viruses
Authors: Golovinov I. V. , Goncharova A. S. , Shulga A. A. , Vlasov S. N. , Dimitriadi S. N. 
Published: January 2025

Oncolytic viruses (OVs) are a new class of targeted anticancer drugs with unique mechanisms of action. Oncolytic virotherapy has evolved from the use of in vitro-passaged strains (first generation) to genetically engineered viruses with increased selectivity (second generation) and, ultimately, to recombinant OVs expressing a transgene (third generation).The aim of the review was to analyze and summarize data on the current state of clinical research on OVs.A PubMed search identified 182 articles from 1997 to 2024 with 154 studies reporting data on 4,850 patients. We found that adenovirus (n = 44) is the most common OV in clinical trials with more than two-thirds (n = 108) using modified or recombinant viral backbones, and granulocyte-macrophage colony-stimulating factor (GM-CSF; n = 40) was the most common transgene. The most common tumors targeted were melanoma (n = 1,997) and gastrointestinal (GI; n = 916) cancers with the most common monotherapy received by intratumoral (n = 3,003) or intravenous (n = 1,318) delivery routes. The most common combination included chemotherapy (n = 54).Treatment-related adverse events included low-grade constitutional symptoms and local injection site reactions. Measurements of virus shedding were frequently performed, but many studies were limited to blood and tumor tissue analysis, using only polymerase chain reaction (PCR). Although most studies reported antiviral antibody titers (n = 101), only a few reported virus-specific T-cell responses (n = 23). Objective responses were recorded in 458 (9.4%) patients and disease control was achieved in 1,141 (23.5%) patients, although standard reporting criteria were used in only 60.4% of cases.These data provide an insight into the current state of clinical research on OVs and highlight potential areas requiring further investigation to better define the role of OVs in cancer treatment.
Markers of gastrointestinal diseases
Authors: Ostanko V. L. , Kalacheva T. P. , Kulumaeva K. A. , Li N. A. , Beloborodova E. V. , Purlik I. L. , Kalyuzhina E. V. , Brazovskaya N. G. , Kalyuzhin V. V. 
Published: January 2025

The lifestyle of people nowadays and poor diet are factors affecting the increasing incidence of digestive diseases in people all over the world. The search for new methods of early diagnosis of the disease is an urgent issue of modern medicine. In the last decade, much attention has been paid to various biological markers that can be used to assess the risk of disease development, the response to therapy, and the possible development of complications. Biomarkers in clinical medicine can be used as additional tools not only to improve early diagnosis of gastrointestinal diseases but also to assess the effectiveness of therapy.The aim of this lecture was to analyze and systematize biomarkers in various gastrointestinal diseases.
The importance of biodiversity of human microbiota and environment in the susceptibility to the development of bronchial asthma in children
Authors: Sokolova T. S. , Malchuk V. N. , Nogai A. A. , Fedorova O. S. , Ogorodova L. M. 
Published: January 2025

Bronchial asthma (BA) remains one of the most common chronic respiratory diseases in childhood. BA develops with a combination of genetic predisposition and environmental factors. Epidemiological data on the development of BA emphasize the role of early-life microbiota in the formation of immune responses and susceptibility to the development of BA. In recent years, enough data has been accumulated to suggest that an imbalance in intestinal and airway microbiota during early life may predispose a child to the development of BA. In turn, the biodiversity of the environment influences the colonization of various biotopes in the human body by microorganisms. The study of the mechanisms of interaction between microbiota communities of the environment and humans will pave the way for the development of new strategies for the prevention of BA.The aim of this review was to analyze current research aimed at assessing the importance of biodiversity of human microbiota and environment in the susceptibility to the development of BA in children.