bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Darkness We Meet: Annie Ernaux’s Account of Care and Dementia
Authors: Stončikaitė Ieva , Ortega Montero Óscar 
Published: December 2023

Abstract

Background and Objectives
The complexities surrounding aging, dementia, and care are timely issues that transcend beyond institutional boundaries, evincing a critical debate on later life across disciplines. The aim of this study is to offer fresh insights into the intricate paradigms of living and growing older with dementia. The study focuses on the Nobel Prize-winning author Annie Ernaux’s memoir I Remain in Darkness (1999), which provides a candid account of her mother’s journey through dementia from its onset to the gradual decline.

Research Design and Methods
This article employs the theoretical frameworks of literary gerontology, illness narratives and life writing to address the challenges of aging, dementia and care that are represented in Ernaux’s memoir. It also addresses societal attitudes and stigma associated with aging and dementia by exploring the embarrassment that individuals and families experience when confronted with the deteriorating mental health of their loved ones.

Results
Ernaux’s memoir explores the nuances of dementia and caregiving within both the familial and institutional context, and sheds light on the complex relationship between a mother and a daughter. Through the act of witnessing, Ernaux embarks on a path of healing, which allows her to confront her past wounds and better navigate the challenges that lie ahead. However, Ernaux’s confessional memoir also troubles the ethics of life writing and identity issues, and seems to perpetuate the pathologizing medical gaze through the exposure of her mother’s vulnerability and intimacy in the face of dementia and care.

Discussion and Implications
Ernaux’s account of her mother’s dementia and aging is both a confessional piece of writing and a narrative therapy, which reveals the challenges of aging, illness, and unresolved family tensions. Her work illuminates the interconnectedness between the past, present, and future, and shows that illness narratives can act as a catalyst for transformative change, identity formation, and self-reflection. The article addresses the intricacies of old age, showcasing how life writing and humanities-based inquiry can bring to the fore key aspects of the latest stages in life, which are often unvoiced because they represent the most unpleasant and feared aspects of aging in contemporary society.
PIECES of My RELATIONSHIPS: The Cultural Adaptation of a Biographical Assessment Tool for Indigenous Older Adults in Canada
Authors: Jacklin Kristen , Pitawanakwat Karen , Blind Melissa , Ketcher Dana , Jones Louise , Piraino Emily , Bretzlaff Monica 
Published: December 2023

Abstract

Background and Objectives
Healthcare services are rarely designed to meet the needs of Indigenous people, resulting in culturally unsafe care and assessment tools. This paper describes a collaboration between North East Behavioural Supports Ontario (NEBSO), university researchers, and Indigenous communities to adapt a biographical assessment tool used by NEBSO to be culturally appropriate and safe for Indigenous older adults (55+) in long-term care facilities in Ontario, Canada.

Research Design and Methods
Over 36 months, this project applied an Indigenized, community-based participatory research (CBPR) and cultural safety framework to the adaptation process. Qualitative data sources include the guidance of an Indigenous Elder, an Anishinaabe Language Expert Group, and focus groups conducted along the North Shore of Lake Huron, Sudbury, and Cochrane, Ontario.

Results
The adapted tool shifts the focus from personhood to relationships, includes culturally relevant domains, and supports trauma-informed approaches. Five themes were identified during the adaptation process: (1) practicing a relational approach to care, (2) valuing Indigenous language, (3) understanding Indigenous trauma, (4) respecting cultural values and understandings, and (5) addressing systemic barriers to culturally safe care.

Discussion and Implications
Themes elucidated from this research process can inform future studies adapting mainstream practice tools and developing new tools for Indigenous populations. The collaboration and approach to this adaptation process demonstrated how cultural safety at systemic and practice levels can be addressed through CPBR partnerships between universities, organizations, and Indigenous communities. Findings support the need to evaluate the cultural safety of other assessments for older Indigenous adults in health care settings.
Protests, long-term preferences, and populism: Evidence from 1968 in Europe
Authors: Fazio Andrea 
Published: December 2023

Abstract
In 1968, young people grew up in an atmosphere of strong dissatisfaction and distrust against the status quo. We show that higher exposure to protests in 1968 leads to higher dissatisfaction toward national governments and raises the probability of voting for populist parties. Consistently with the impressionable years hypothesis, we find these effects valid only for those aged between 18 and 25 years during 1968. Our results are robust to a series of placebo tests and to alternative definitions of our treatment and control groups. We find that our results are driven by individuals with a middle or low level of education. We also find suggestive evidence that the mechanisms driving our results can depend on individuals’ level of education.
Who Should Scale Back? Experimental Evidence on Employer Support for Part-Time Employment and Working Hours Norms for Couples with Young Children
Authors: Philipp Marie-Fleur , Büchau Silke , Schober Pia S 
Published: December 2023

Abstract
This experimental study investigates how hypothetical employer support for part-time work shapes working hours norms for mothers and fathers with young children in Germany. It extends previous studies by focusing on the couple context, for instance by exploring interdependencies with each partner’s earnings potential. The analysis is framed using capability-based explanations combined with a perspective of gender as a social structure. A factorial survey experiment was implemented within the German pairfam panel. Linear and multinomial logistic multilevel regressions were conducted with 5,856 respondents. Hypothetical employer support similarly increases respondents’ recommendations to reduce working hours for mothers and fathers and supports dual part-time arrangements. In couples who face opposing incentives in terms of relative earnings or promotion prospects and employer support for part-time work, prevailing gender norms seem to reinforce the traditionalizing constraints and attenuate the de-traditionalizing influence. Respondents with more egalitarian gender beliefs respond more strongly to paternal employer support.
Host-Specific and Homologous Pairs of Melampsora larici-populina Effectors Unveil Novel Nicotiana benthamiana Stromule Induction Factors
Authors: Letanneur Claire , Brisson Alexandre , Bisaillon Mathias , Devèze Théo , Plourde Mélodie B. , Schattat Martin , Duplessis Sébastien , Germain Hugo 
Published: December 2023

The poplar rust fungus Melampsora larici-populina is part of one of the most devastating group of fungi (Pucciniales) and causes important economic losses to the poplar industry. Because M. larici-populina is a heteroecious obligate biotroph, its spread depends on its ability to carry out its reproductive cycle through larch and then poplar parasitism. Genomic approaches have identified more than 1,000 candidate secreted effector proteins (CSEPs) from the predicted secretome of M. larici-populina that are potentially implicated in the infection process. In this study, we selected CSEP pairs (and one triplet) among CSEP gene families that share high sequence homology but display specific gene expression profiles among the two distinct hosts. We determined their subcellular localization by confocal microscopy through expression in the heterologous plant system Nicotiana benthamiana. Five out of nine showed partial or complete chloroplastic localization. We also screened for potential protein interactors from larch and poplar by yeast two-hybrid assays. One pair of CSEPs and the triplet shared common interactors, whereas the members of the two other pairs did not have common targets from either host. Finally, stromule induction quantification revealed that two pairs and the triplet of CSEPs induced stromules when transiently expressed in N. benthamiana. The use of N. benthamiana eds1 and nrg1 knockout lines showed that CSEPs can induce stromules through an eds1-independent mechanism. However, CSEP homologs shared the same impact on stromule induction and contributed to discovering a new stromule induction cascade that can be partially and/or fully independent of eds1. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
STELLATE GANGLION BLOCK REVERSES PHSML-INDUCED VASCULAR HYPOREACTIVITY THROUGH INHIBITING AUTOPHAGY-MEDIATED PHENOTYPIC TRANSFORMATION OF VSMCs
Authors: Li Cai-Juan , Du Hui-Bo , Zhao Zhen-Ao , Sun Qi , Li Yi-Ming , Chen Si-Jie , Zhang Hong , Zhang Nan , Niu Chun-Yu , Zhao Zi-Gang 
Published: December 2023

ABSTRACTPosthemorrhagic shock mesenteric lymph (PHSML) return–contributed excessive autophagy of vascular smooth muscle cells (VSMCs) is involved in vascular hyporeactivity, which is inhibited by stellate ganglion block (SGB) treatment. The contractile phenotype of VSMCs transforms into a synthetic phenotype after stimulation with excessive autophagy. Therefore, we hypothesized that SGB ameliorates PHSML-induced vascular hyporeactivity by inhibiting autophagy-mediated phenotypic transformation of VSMCs. To substantiate this hypothesis, a hemorrhagic shock model in conscious rats was used to observe the effects of SGB intervention or intravenous infusion of the autophagy inhibitor 3-methyladenine (3-MA) on intestinal blood flow and the expression of autophagy- and phenotype-defining proteins in mesenteric secondary artery tissues. We also investigated the effects of intraperitoneal administration of PHSML intravenous infusion and the autophagy agonist rapamycin (RAPA) on the beneficial effect of SGB. The results showed that hemorrhagic shock decreased intestinal blood flow and enhanced the expression of LC3 II/I, Beclin 1, and matrix metalloproteinase 2, which were reversed by SGB or 3-MA treatment. In contrast, RAPA and PHSML administration abolished the beneficial effects of SGB. Furthermore, the effects of PHSML or PHSML obtained from rats treated with SGB (PHSML-SGB) on cellular contractility, autophagy, and VSMC phenotype were explored. Meanwhile, the effects of 3-MA on PHSML and RAPA on PHSML-SGB were observed. The results showed that PHSML, but not PHSML-SGB, incubation decreased VSMC contractility and induced autophagy activation and phenotype transformation. Importantly, 3-MA administration reversed the adverse effects of PHSML, and RAPA treatment attenuated the effects of PHSML-SGB incubation on VSMCs. Taken together, the protective effect of SGB on vascular reactivity is achieved by inhibiting excessive autophagy-mediated phenotypic transformation of VSMCs to maintain their contractile phenotype.
Invasive Hemodynamic Monitoring with Pulmonary Artery Catheter in Sepsis-associated Cardiogenic Shock
Authors: Sato Ryota , Hasegawa Daisuke , Guo Stephanie C. , Nishida Kazuki , Dugar Siddharth 
Published: December 2023

Abstract

Background
Both sepsis-induced cardiomyopathy and worsening of pre-existing cardiac disease can contribute to circulatory shock in septic patients, The early use of pulmonary artery catheter (PAC) could play a pivotal role in the management of sepsis-associated cardiogenic shock. In this study, we aimed to evaluate the impact of early invasive hemodynamic monitoring with PAC in patients with sepsis-associated cardiogenic shock.

Method
We performed a retrospective study using the National Inpatient Sample data from 01/2017 to 12/2019. The early use of PAC was defined as the use of PAC within 2 days from the admission. We performed the multivariable logistic regression analysis to investigate the association between the early use of PAC and in-hospital mortality in patients with sepsis-associated cardiogenic shock and sepsis without cardiogenic shock, respectively.

Results
There was no difference in in-hospital mortality between PAC and No PAC groups in sepsis without cardiogenic shock (adjusted odds ratio [aOR]: 1.05, 95% confidence interval [CI]: 0.82 – 1.35, p = 691). On the other hand, the early use of PAC was independently associated with lower in-hospital mortality in patients with sepsis-associated cardiogenic shock (aOR: 0.58, 95% confidence interval [CI]: 0.46 – 0.72, p < 0.001). The use of PAC was also associated with increased use of MCS in those with sepsis-associated cardiogenic shock (aOR: 12.26, 95% CI: 9.37 – 16.03, p < 0.001). For patients with sepsis-associated cardiogenic shock, the use of PAC after 2 days of admission was associated with significantly higher in-hospital mortality and decreased use of mechanical circulatory support.

Conclusion
The use of pulmonary artery catheters in sepsis-associated cardiogenic shock was associated with significantly lower in-hospital mortality and increased use of mechanical circulatory supports in patients with sepsis-associated cardiogenic shock.
PROGNOSTIC PERFORMANCE OF SERIAL DETERMINATION OF THE SOCIETY FOR CARDIOVASCULAR ANGIOGRAPHY AND INTERVENTIONS SHOCK CLASSIFICATION IN ADULTS WITH CRITICAL ILLNESS
Authors: Jentzer Jacob C. , Sanghavi Devang , Patel Parag C. , Bhattacharyya Anirban , van Diepen Sean , Herasevich Vitaly , Gajic Ognjen , Kashani Kianoush B. 
Published: December 2023

ABSTRACTPurpose:The aim of the study is to evaluate whether serial assessment of shock severity can improve prognostication in intensive care unit (ICU) patients.Materials and Methods:This is a retrospective cohort of 21,461 ICU patient admissions from 2014 to 2018. We assigned the Society for Cardiovascular Angiography and Interventions (SCAI) Shock Stage in each 4-h block during the first 24 h of ICU admission; shock was defined as SCAI Shock stage C, D, or E. In-hospital mortality was evaluated using logistic regression.Results:The admission SCAI Shock stages were as follows: A, 39.0%; B, 27.0%; C, 28.9%; D, 2.6%; and E, 2.5%. The SCAI Shock stage subsequently increased in 30.6%, and late-onset shock developed in 30.4%. In-hospital mortality was higher in patients who had shock on admission (11.9%) or late-onset shock (7.3%)versusno shock (4.3%). Persistence of shock predicted higher mortality (adjusted OR = 1.09; 95% CI = 1.06–1.13, for each ICU block with shock). The mean SCAI Shock stage had higher discrimination for in-hospital mortality than the admission or maximum SCAI Shock stage. Dynamic modeling of the SCAI Shock classification improved discrimination for in-hospital mortality (C-statistic = 0.64–0.71).Conclusions:Serial application of the SCAI Shock classification provides improved mortality risk stratification compared with a single assessment on admission, facilitating dynamic prognostication.
THE ROLE OF N6-METHYLADENOSINE METHYLTRANSFERASE RBM15 IN NONALCOHOLIC FATTY LIVER DISEASE
Authors: Li Shiqing , Lian Shengyi , Cheng Wei , Zhang Tao , Gong Xiaobing 
Published: December 2023

ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disorder with significant health implications. N6-methyladenosine (m6A) methyltransferase is known to exert regulatory functions in liver-related diseases. This study investigates the intricate role of RNA binding motif protein 15 (RBM15) in modulating inflammation and oxidative stress in NAFLD. An NAFLD model was induced in mice (male, C57BL/6J, 72 mice in the sham group) through a high-fat diet for 9 weeks, and hepatocytes were exposed to long chain-free fatty acids. The expression levels of RBM15, ring finger protein 5 (RNF5), and rho-kinase 1 (ROCK1) were assessed. RBM15 expression was intervened (injection of AAV9 virus at week 9 and detection at week 11). Liver damage was evaluated using staining assays, along with assessments of weight changes and lipid levels. Notably, RBM15 (decreased approximately 40%/60%) and RNF5 (decreased approximately 60%/75%) were poorly expressed while ROCK1 (increased approximately 2.5-fold) was highly expressed in liver tissues and cells. RBM15 overexpression mitigated liver damage, inflammation, and oxidative stress in NAFLD mice, resulting in reduced liver-to-body weight ratio (20%) and decreased levels of alanine aminotransferase (54%), aspartate aminotransferase (36%), total cholesterol (30%), and triglycerides (30%), and inhibited inflammation and oxidative stress levels. Mechanistically, RBM15 upregulated RNF5 expression through m6A methylation modification, and RNF5 suppressed ROCK1 protein levels through ubiquitination modification. RNF5 knockdown or ROCK1 overexpression accelerated inflammation and oxidative stress in NAFLD. Taken together, RBM15 upregulated RNF5 expression through m6A methylation modification. RNF5 inhibited ROCK1 expression through ubiquitination modification to mitigate NAFLD.
Roadmap for modern development of Chinese medicine: Traditional, evidence-based, and digital-intelligent paths
Authors: Zhang Xiaoyu , Zhang Xiaowei , Li Xiao , Wang Shuangqiu , Zhao Chen , Chen Zhao , You Liangzhen , Jiang Yin , Lin Hongyuan , Wei Xuxu , Xiong Jun , Chen Xiaofan , Jin Yinghui , Xu Xue , Shang Hongcai 
Published: December 2023

Abstract
Accelerating the modernization of Chinese medicine (CM) is the focus of CM development in the new era. Looking back over the past 50 years, CM has progressed along traditional, evidence-based, and digital-intelligent paths. These paths have intertwined and mutually propelled the advancement of CM modernization. This article analyzes the patterns of 3 paths, summarizes the current status of CM development along these paths, and presents a vision for future development.
Genetic variants inDDX53contribute to Autism Spectrum Disorder associated with the Xp22.11 locus
Authors: Scala Marcello , Bradley Clarrisa A. , Howe Jennifer L. , Trost Brett , Salazar Nelson Bautista , Shum Carole , Reuter Miriam S. , MacDonald Jeffrey R. , Ko Sangyoon Y. , Frankland Paul W. , Granger Leslie , Anadiotis George , Pullano Verdiana , Brusco Alfredo , Keller Roberto , Parisotto Sarah , Pedro Helio F. , Lusk Laina , McDonnell Pamela Pojomovsky , Helbig Ingo , Mullegama Sureni V. ,   Undiagnosed Diseases Network, Douine Emilie D. , Russell Bianca E. , Nelson Stanley F. , Zara Federico , Scherer Stephen W. 
Published: December 2023

SummaryAutism Spectrum Disorder (ASD) exhibits an ∼4:1 male-to-female sex bias and is characterized by early-onset impairment of social/communication skills, restricted interests, and stereotyped behaviors. Disruption of the Xp22.11 locus has been associated with ASD in males. This locus includes the three-exonPTCHD1gene, an adjacent multi-isoform long noncoding RNA (lncRNA) namedPTCHD1-AS(spanning ∼1Mb), and a poorly characterized single-exon RNA helicase namedDDX53that is intronic toPTCHD1-AS. While the relationship betweenPTCHD1/PTCHD1-ASand ASD is being studied, the role ofDDX53has not been examined, in part because there is no apparent functional murine orthologue. Through clinical testing, here, we identified 6 males and 1 female with ASD from 6 unrelated families carrying rare, predicted-damaging or loss-of-function variants inDDX53. Then, we examined databases, including the Autism Speaks MSSNG and Simons Foundation Autism Research Initiative, as well as population controls. We identified 24 additional individuals with ASD harboring rare, damagingDDX53variations, including the same variants detected in two families from the original clinical analysis. In this extended cohort of 31 participants with ASD (28 male, 3 female), we identified 25 mostly maternally-inherited variations inDDX53, including 18 missense changes, 2 truncating variants, 2 in-frame variants, 2 deletions in the 3’ UTR and 1 copy number deletion. Our findings in humans support a direct link betweenDDX53and ASD, which will be important in clinical genetic testing. These same autism-related findings, coupled with the observation that a functional orthologous gene is not found in mouse, may also influence the design and interpretation of murine-modelling of ASD.
HumanELY: Human evaluation of LLM yield, using a novel web-based evaluation tool
Authors: Awasthi Raghav , Mishra Shreya , Mahapatra Dwarikanath , Khanna Ashish , Maheshwari Kamal , Cywinski Jacek , Papay Frank , Mathur Piyush 
Published: December 2023

AbstractLarge language models (LLMs) have caught the imagination of researchers,developers and public in general the world over with their potential for transformation. Vast amounts of research and development resources are being provided to implement these models in all facets of life. Trained using billions of parameters, various measures of their accuracy and performance have been proposed and used in recent times. While many of the automated natural language assessment parameters measure LLM output performance for use of language, contextual outputs are still hard to measure and quantify. Hence, human evaluation is still an important measure of LLM performance,even though it has been applied variably and inconsistently due to lack of guidance and resource limitations.To provide a structured way to perform comprehensive human evaluation of LLM output, we propose the first guidance and tool called HumanELY. Our approach and tool built using prior knowledge helps perform evaluation of LLM outputs in a comprehensive, consistent, measurable and comparable manner. HumanELY comprises of five key evaluation metrics: relevance, coverage, coherence, harm and comparison. Additional submetrics within these five key metrics provide for Likert scale based human evaluation of LLM outputs. Our related webtool uses this HumanELY guidance to enable LLM evaluation and provide data for comparison against different users performing human evaluation. While all metrics may not be relevant and pertinent to all outputs, it is important to assess and address their use.Lastly, we demonstrate comparison of metrics used in HumanELY against some of the recent publications in the healthcare domain. We focused on the healthcare domain due to the need to demonstrate highest levels of accuracy and lowest levels of harm in a comprehensive manner. We anticipate our guidance and tool to be used for any domain where LLMs find an use case.Link to the HumanELY Toolhttps://www.brainxai.com/humanely