bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiographic growth rate as a predictor of aggressiveness of diffuse gliomas without 1p19q codeletion
Authors: Leclerc Arthur , Roux Alexandre , Elia Angela , Peeters Sophie , Aboubakr Oumaima , Bedioui Aziz , Planet Martin , Benzakoun Joseph , Simboli Giorgia Antonia , Tauziede-Espariat Arnault , Moiraghi Alessandro , Varlet Pascale , Chrétien Fabrice , Oppenheim Catherine , Zanello Marc , Pallud Johan 
Published: February 2024

OBJECTIVE
The 2021 WHO classification of CNS tumors has refined the definition of adult-type diffuse gliomas without 1p19q codeletion. Nevertheless, the aggressiveness of gliomas is based exclusively on histomolecular criteria performed on a limited sample of the tumor. The authors aimed to assess whether the spontaneous radiographic tumor growth rate is associated with tumor aggressiveness and allows preoperative identification of malignancy grade of adult-type diffuse gliomas without 1p19q codeletion.

METHODS
The authors retrospectively reviewed the records of adult patients harboring a newly diagnosed supratentorial diffuse glioma without 1p19q codeletion, with available preoperative MRI follow-up between January 2008 and April 2022. The spontaneous radiographic tumor growth rate was quantified by tumor volume segmentation and regression of the evolution of the mean tumor diameter over time and was compared with clinical, imaging, histomolecular, and survival data.

RESULTS
Ninety-six patients were included. The spontaneous radiographic tumor growth rates (mean 17.8 ± 38.8 mm/year, range 0–243.5 mm/year) significantly varied according to IDH1/2 mutation (p < 0.001), grade of malignancy (p < 0.001), and presence of microvascular proliferation (p < 0.001). The spontaneous radiographic tumor growth rate allowed preoperative identification of high-grade cases: 100% of grade 3 and 4 IDH-mutant diffuse astrocytomas had a spontaneous radiographic tumor growth rate ≥ 8.0 mm/year, and 100% of IDH–wild-type glioblastomas had a spontaneous radiographic tumor growth rate ≥ 42.0 mm/year. A spontaneous radiographic growth rate ≥ 8.0 mm/year was an independent predictor of shorter progression-free (p = 0.014) and overall (p = 0.007) survival. A mitotic count threshold ≥ 4 mitoses was the optimal threshold for identifying aggressive IDH-mutant astrocytomas based on spontaneous radiographic tumor growth.

CONCLUSIONS
The spontaneous radiographic tumor growth rates could be used as an additional tool to preoperatively screen tumor aggressiveness of adult-type diffuse gliomas without 1p19q codeletion.
The role of preoperative [11C]methionine PET in defining tumor-related epilepsy and predicting short-term postoperative seizure control in temporal lobe low-grade gliomas
Authors: Bono Beatrice C. , Ninatti Gaia , Riva Marco , Raspagliesi Luca , Barbieri Edoardo M. , Navarria Pierina , Clerici Elena , Politi Letterio S. , Simonelli Matteo , Rodari Marcello , Sollini Martina , Chiti Arturo , Pessina Federico 
Published: February 2024

OBJECTIVE
Surgery is the mainstay of treatment for low-grade glioma (LGG)–related epilepsy. However, the goal of achieving both oncological radical resection and seizure freedom can be challenging. PET with [11C]methionine (MET) has been recently introduced in clinical practice for the management of patients with LGGs, not only to monitor the response to treatments, but also as a preoperative tool to define the metabolic tumor extent and to predict tumor grading, type, and prognosis. Still, its role in defining tumor-related epilepsy and postoperative seizure outcomes is limited. The aim of this preliminary study was to investigate the role of MET PET in defining preoperative seizure characteristics and short-term postoperative seizure control in a cohort of patients with newly diagnosed temporal lobe low-grade gliomas (tLGGs).

METHODS
Patients with newly diagnosed and histologically proven temporal lobe grade 2/3 gliomas (2021 WHO CNS tumor classification) who underwent resection at the authors’ institution between July 2011 and March 2021 were included in this retrospective study. MET PET images were acquired, fused with MRI scans, and qualitatively and semiquantitatively analyzed. Any eventual PET/MRI involvement of the temporomesial area, seizure characteristics, and 1-year seizure outcomes were reported.

RESULTS
A total of 52 patients with tLGGs met the inclusion criteria. MET PET was positive in 41 (79%) patients, with a median metabolic tumor volume of 14.56 cm3 (interquartile range [IQR] 6.5–28.2 cm3). The median maximum and mean tumor-to-background ratio (TBRmax, TBRmean) were 2.24 (IQR 1.58–2.86) and 1.53 (IQR 1.37–1.70), respectively. The metabolic tumor volume was found to be related to the presence of seizures at disease onset, but only in noncodeleted tumors (p = 0.014). Regarding patients with uncontrolled seizures at surgery, only the temporomesial area PET involvement showed a statistical correlation both in the univariate (p = 0.058) and in the multivariate analysis (p = 0.030). At 1-year follow-up, seizure control was correlated with MET PET–derived semiquantitative data. Particularly, higher TBRmax (p = 0.0192) and TBRmean (p = 0.0128) values were statistically related to uncontrolled seizures 1 year after surgery.

CONCLUSIONS
This preliminary study suggests that MET PET may be used as a preoperative tool to define seizure characteristics and outcomes in patients with tLGGs. These findings need to be further validated in larger series with longer epileptological follow-ups.
A PERFORMANCE MEASUREMENT IN THE FRAMEWORK OF THE BALANCED SCORECARD: ITS IMPLEMENTATION AT THE PUBLIC SECTOR
Authors: Biswan Ali Tafriji , Sholikhah Mar'atus , Sandi Hendrik Heri 
Published: February 2024

This study aimed to reveal the essence of the uniqueness of the balanced scorecard practice in the public sector based on its dynamics and characteristics. This qualitative research utilized a case study model combining literacy, data processing, in-depth interviews, and the researchers’ involvement. The results of the study indicate that the balanced scorecard can be adapted to an organization's vision and mission. Meanwhile, the customer perspective can be further divided into several perspectives, such as service partners and the stakeholder perspective, which became the ultimate goal of services. However, the financial aspect remained important and relevant for the object of the study even though it was not developed into a financial perspective independently. Instead, this aspect is included as a strategic objective from the perspective of learning and growth. In addition, the sharpening of the Key Performance Indicators (KPI) is also carried out after the results of the KPI achievement are measured and evaluated. Keywords: Performance Measurement, Balanced Scorecard, Key Performance Indicators, Public Sector.
ANALYSIS OF PROFESSIONALITY OF BHAYANGKARA PERSONNEL OPERATIONAL AT THE STATE SECURITY DIRECTORATE OF THE SECURITY INTELLIGENCE AGENCY OF INDONESIAN NATIONAL POLICE
Authors: Resdiana Artanti , Ridwan Radjab Ridwan , Widjayanti Arifiani 
Published: February 2024

The professionalism of State Security Directorate personnel is crucial for achieving superior, sharp, and reliable security intelligence. However, there is ambiguity in the placement of operational supervisory roles within the Directorate. The researcher identifies performance, competence, Loyalty, and accountability as key factors influencing the professionalism of the Indonesian National Police Security Intelligence's operational supervisory personnel (BOP). The research's primary objective is to analyze the issues surrounding the mismatch between BOP placements and operational directorate needs. It also aims to devise effective strategies to enhance BOP personnel professionalism. The research employs qualitative methods, including literature review, observations at the State Security Directorate, and interviews. The findings reveal three main issues. First, suboptimal professionalism is attributed to inadequate technical, managerial, and sociocultural competencies affecting performance. Second, the soft tools, such as career policies and functional positions in the Security Intelligence operational directorate, need optimization. Finally, increased performance, competence, Loyalty, and accountability are vital drivers for enhancing the professionalism of operational supervisory personnel within the State Security Directorate of the Indonesian National Police Security Intelligence Agency. Keywords: performance, competence, Loyalty, accountability and professionalism
IMPLEMENTASI AKAD MURABAHAH PADA PEMBIAYAAN MIKRO DI BANK SYARIAH INDONESIA INDRAMAYU KCP SOEPRAPTO
Authors: Himmawan Didik , Suharmono Soni , Permana Ujang , Dewi Annisa 
Published: February 2024

Pembiayaan kepada masyarakat merupakan salah satu hal yang sangat dibutuhkan untuk membantu meningkatkan keadaan ekonomi masyarakat. BSI merupakan sebuah lembaga keuangan yang salah satu tugasnya adalah menyalurkan dana pembiayaan kepada masyarakat yang telah menerapkan prinsip kehati-hatian dalam pembiayaan modal kerja dengan menggunakan beberapa akad salah satunya akad Murabahah, sehingga dapat dijadikan salah satu instansi pembiayaan yang terpercaya oleh masyarakat dan aman bagi kesehatan bank. Penelitian ini bertujuan untuk mengetahui bagaimana implementasi akad murabahah pada pembiayaan mikro di BSI Indramayu KCP Soeprapto. Metode untuk mengalisis penelitian ini menggunakan deskriptif kualitatif, metode pengumpulan data menggunakan penelitian lapangan (field research). Berdasarkan hasil penelitian, implementasi akad murabahah pada pembiayaan mikro di BSI KCP Soeprapto sesuai dengan fatwa DSN MUI. Dalam pembiayaan mikro, BSI Suprapto menggunakan akad Murabahah bil wakalah. Tentunya dengan prosedur yang dan syarat yang telah ditentukan.
Komunikasi Antarbudaya Perspektif Al-Qur’an
Authors: Nurazizah Nurazizah 
Published: February 2024

Komunikasi merupakan suatu kegiatan berinteraksi yang dilakukan dalam kehidupan sehari-hari manusia. Namun dalam membangun komunikasi tentu banyak mengalami hambatan (noise) khususnya bagi masyarakat Indonesia. Seperti yang diketahui masyarakat Indonesia tergolong masyarakat heterogen, karena terdiri dari berbagai ragam suku, budaya, agama, Bahasa dan adat istiadat. Sehingga disitulah peran komunikasi antar budaya. Komunikasi antar budaya merupakan interaksi yang dilakukan individu kepada individu dan masyarakat yang lainnya yang berbeda latar belakang baik suku, ras, bangsa, budaya, bahasa dan sebagainya. Dengan tujuan untuk mengetahui dan memahami satu sama lain. Komunikasi antar budaya juga tidak dapat terlepas dari Al-Qur’an yang menjadi landasan atau pedoman dalam proses berkomunikasi. Penelitian ini bertujuan untuk menjelaskan relevansi dan menganalisis komunikasi antarbudaya perspektif Al-Qur’an. Penelitian ini menggunakan metode library research (penelitian Pustaka) dengan pendekatan tafsir tematik. Sumber data utama dan paling utama dalam penelitian ini adalah Al-Qur’an, kitab-kitab tafsir yang dibatasi pada kitab-kitab yang dipandang refresentatif. Studi ini menemukan beberapa ayat Al-Qur’an yang menjelaskan mengenai komunikasi antarbudaya yang bisa dijadikan pedoman dalam menjalin komunikasi serta bagaimana menyelesaikan konflik antarbudaya maupun kelompok. Sebagaimana yang telah dijelaskan dalam Qs. Al-Hujurat: 13, Qs. Al-Kafirun: 6, dan QS. Ali Imran Ayat 103.
Efficacy of an iron-fortified gummy on iron-deficiency anemia in young women
Authors: Xiao Yan , Yang Bingjie , Ni Jiayi , Hu Ran 
Published: February 2024

Objective: We conducted this single-center, double-blinded, randomized and placebo-controlled study to explore the efficacy of an iron-fortified gummy on relieving iron-deficiency anemia in young Chinese women. Participants’ blood hemoglobin level was set as the primary outcome. The secondary objectives were to assess the effects of the iron-fortified gummy on participants’ blood iron levels, skin barrier functions, skin temperature regulating ability, menstruation and leucorrhea status, sleep quality, and overall quality of life.Methods: Seventy female participants aged 18-35 years with moderate iron-deficiency anemia (blood hemoglobin 90-120 g/L) were recruited and randomly assigned to an intervention group or a placebo group. We supplemented the diets of the participants with an iron-fortified gummy or a placebo for eight weeks. Their blood hemoglobin level, iron biomarkers, skin biophysical characteristics, hand temperature, self-reported menstruation and leucorrhea status, life quality and sleep quality were recorded at baseline, mid-way through the study and the end of the study. We compared the differences of the above outcomes between the intervention group and the control group. Results: After eight weeks of daily iron-fortified gummy intake, 80% of the participants showed improvement in blood hemoglobin concentration, with a mean increase of 14.5 g/L (95% confidence interval: 9.4, 19.5 g/L) compared to the control. Their serum iron and ferritin levels had significantly increased. They also had improved facial skin hydration and complexions, reduced transepidermal water loss, and accelerated temperature recovery in their hands. Intake of the iron-fortified gummy effectively reduced the incidence of menstrual headaches and insomnia. Participants reported prolonged sleep time, improved energy level, mobility, mental concentration, ability to engage in daily activities and work, as well as better perception of quality of life and health satisfaction.Conclusion:Daily consumption of the iron-fortified gummy over eight weeks could help build up blood iron levels to generate hemoglobin, relieve iron-deficiency anemia and related symptoms in young Chinese women. Intake of iron through gummy on a daily basis is an effective method to gradually increase the participants’ iron levels, leading to sustainable long-term benefits.Study registration: Chinese Clinical Trial Registry (ChiCTR2200061345).
PERAN MEDIASI TOLERANSI RISIKO DALAM ANALISIS DETERMINASI KEPUTUSAN INVESTASI MAHASISWA KOTA DENPASAR
Authors: Prabandari Tri Putri I Gusti Agung , Yuliana Ria Sawitri Ni Putu , Wijaya Bagus Arya , Sudiyani Ni Nyoman 
Published: February 2024

Student investment decisions are financial behavior and a form of awareness to achieve financial freedom and well-being at a young age. This study aims to examine the mediating role of student risk tolerance in making investment decisions based on financial literacy, overconfidence bias, and representative bias. The population included students from higher education in Denpasar City who invested in stocks, with non-probability sampling methods and purposive sampling techniques set the number of sample of as many as 105 respondents. Testing of research data using SEM PLS technique. The result proved that financial literacy has a negative and significant effect on investment decisions; overconfidence bias and risk tolerance have a positive and significant effect on investment decisions; while representative bias does not have a significant effect on investment decisions. Overconfidence bias has a positive and significant effect on risk tolerance but financial literacy and representative bias do not have a significant effect on risk tolerance. This study was able to prove that overconfidence bias has a positive and significant effect on investment decisions with risk tolerance as mediation, while risk tolerance is unable to mediate the influence of financial literacy and representative bias on investment decisions.
Keywords: investment decisions, risk tolerance, financial literacy, cognitive bias
Perbaikan Produksi di Pabrik Terasi UD.Berlian dengan Menggunakan CPPB-IRT dan Wise
Authors: Angelita Michelle , Azwar Ade Geovania 
Published: February 2024

Penelitian dilakukan pada pabrik terasi UD.Berlian yang terletak di Desa Tambak Indramayu, Jawa Barat. Permasalahan pada pabrik terasi UD.Berlian yakni karyawan masih belum memahami Cara Produksi Pangan Yang Baik-Industri Rumah Tangga(CPPB-IRT) dan Work Improvement In Small Enterprises WISE. Diperoleh hasil ketidaksesuaian yakni 9% pada CPPB-IRT dan 26% pada WISE.Tujuan dilakukan penelitian ini yakni untuk menentukan perbaikan proses produksi dengan menggunakan matriks perbandingan berpasangan. Tujuan lainnya yakni untuk membuat usulan perbaikan. Ditemukan 4 (empat) kriteria yang tidak sesuai dengan CPPB-WISE. Kriteria yang tidak sesuai yakni Karyawan, Pemeliharaan, Penyimpanan dan Penanganan Material, Lingkungan Kerja dan Kontrol Bahan Yang Berbahaya. Hasil penelitian yakni karyawan memiliki bobot tertinggi yakni 31%. Diperoleh hasil sub kriteria karyawan dalam keadaan sehat, bebas luka, penyakit kulit memiliki bobot terbesar yakni 29% menjadikan sub kriteria karyawan sehat, bebas luka, penyakit kulit sebagai usulan perbaikan proses produksi
Stock Valuation of Telecommunication Provider in Saudi Arabia with the Case Study of Tawal Spin-Off of Saudi Telecom Company (STC)
Authors: Hidayat Nizar Ihromi , Faturohman Taufik 
Published: February 2024

This study investigates the stock valuation implications of the strategic spin-off plan involving Tawal, the biggest telecom tower infrastructure provider in Saudi Arabia, a 100% owned subsidiary of the Saudi Telecommunications Company (STC). Saudi Public Investment Fund (PIF) has sent a nonbinding offer to acquire 51% of Tawal's shares from the STC group, which is aligned with the Saudi Vision 2030 strategy. The findings of this research contribute nuanced insights into the relationship between spin-offs and stock valuation within the context of the telecommunications industry. By scrutinizing the anticipated impact of the Tawal spin-off on STC stock price, this study provides valuable information for investors and the STC group navigating the strategic decisions and their implications for the stock value. The research employs a comprehensive stock valuation framework with absolute-relative valuation, internal-external analysis, and risk assessment to gauge the potential effects on STC's respective stock values of the Tawal spin-off. Comparative analyses conducted within the telecommunications sector in Saudi Arabia offer valuable benchmarks for assessing the performance of STC Group. According to the intrinsic valuation approach and the Discounted Cash Flow model, STC stock price is undervalued compared to the stock price of 19th November 2023 by 38.3 SAR. Assuming the spin-off failed, obtaining the fair price at 41.5 SAR per share based on the DCF model and 54.2 SAR based on the relative valuation PE ratio. If the Spin-off is agreed upon and concluded, the fair price is valued at 42.6 SAR per share based on the DCF model. Sensitivity analysis and Monte Carlo simulation resulted in two results: the gross profit margin is a sensitive variable of the stock price movement, and the buy option is preferable. In line with that, STC has a solid holding organization, is financially healthy, and has sustained a competitive advantage. STC is expected to deploy the liquidity into investment and expansion in the region and globally, generating a higher return to satisfy the investor interest.
HUBUNGAN KETUBAN PECAH DINI DENGAN KEJADIAN ASFIKSIA NEONATORUM DI RUMAH SAKIT PANTI ABDI DHARMA KOTA CIREBON TAHUN 2022
Authors: Kusumawati Alif Rachma , Rahmatika Siti Difta , Kumalasary Diyanah 
Published: February 2024

Kejadian ketuban pecah dini merupakan salah satu faktor yang menyebabkan terjadinya asfiksia, angka kejadiannya terjadi pada 6-20% kehamilan. Ketuban pecah dini sangat berpengaruh pada kehamilan dan persalinan, makin lama jarak antara pecahnya selaput ketuban makin besar kemungkinan infeksi dalam rahim yang dapat meningkatkan kejadian morbiditas dan mortalitas ibu dan bayi.Tujuan penelitian ini yaitu untuk mengetahui hubungan ketuban pecah dini dengan kejadian asfiksia neonatorum di RS PAD Kota Cirebon Tahun 2022. Metode penelitian ini menggunakan cross sectional. Populasi pada penelitian ini yaitu seluruh persalinan yang tercatat di rekam medik RS PAD Kota Cirebon pada tahun 2021 yaitu 1.026. Sampel dalam penelitian ini menggunakan total sampling yang diambil dari persalinan di tahun 2021.Dari hasil analisis didapatkan angka kejadian ketuban pecah dini (KPD) di RS Panti Abdi Dharma periode Januari – Desember Tahun 2021 sebanyak 248 orang (24.2%) dan angka kejadian Asfiksia Neonatorum di RS Panti Abdi Dharma Kota Cirebon periode tahun 2021 sebanyak 129 orang (12.6%). Berdasarkan hasil peneleitian didapatkan nilai signifikansi 0,000 lebih kecil dari 0,05.Kesimpulan dari penelitian ini yaitu ada hubungan yang signifikan antara ketuban pecah dini dengan kejadian asfiksia neonatorum di RS Panti Abdi Dharma Kota Cirebon Periode tahun 2021. Saran yang direkomendasikan dari hasil penelitian ini dapat digunakan oleh STIKes Muhammadiyah Cirebon, Rekam Medik RS Panti Abdi Dharma Kota Cirebon, dan peneliti selanjutnya.
Effectiveness of open and close kinetic chains after anterior cruciate ligament reconstruction: A systematic review and meta-analysis
Authors: Putri Rizka Salsabila , Perdana Suryo Saputra , Azizah Amalia Nur 
Published: February 2024

Background: The Anterior Cruciate Ligament (ACL) is a ligament that has the function to maintain the stability of the knee so that it does not shift excessively towards the front. ACL injuries are injuries that are often experienced by sports athletes, especially those who often make fast and sudden movements. There are non-operative and operative methods for treating ACL. Non-operative methods are considered less effective because they usually require a slightly longer recovery period. One of the most frequently used surgical methods is reconstruction. After reconstruction, there is a need for exercises to speed up recovery and improve its function. Some examples of exercises that can be used are Open Kinetic Chain (OKC) and Close Kinetic Chain (CKC) exercises.Purpose: To determine the level of effectiveness between OKC and CKC for individual after ACL reconstructionMethod: This research was a systematic review and meta-analysis with the PRISMA diagram to filter supporting articles. To assess the quality of Randomized Controlled Trial (RCT) design studies, the Critical Appraisal Checklist was used. Meanwhile, the Characteristics for Included Studies were used to assess the feasibility. The article search came from the Pubmed database with the keywords "Close Kinetic Chain" AND "Open Kinetic Chain" AND "Anterior Cruciate Ligament" AND "Reconstruction". Inclusion criteria were full text articles in Indonesian or English with an RCT study design. The relationship measure used was Mean Difference, and Revman 5.4. was used for analysis.Results: There were five articles from UK, US and Turkey for this study. The results of the study showed that there was an increasing effect after carrying out OKC and CKC exercises. However, the difference in exercise benefits between OKC and CKC exercises was not notably significant, which were shown by a p-value >0.05 (MD= -1.66; 95% CI=-18.71 to 5.42; P=0.65).Conclusion: OKC and CKC exercises had been proven to have an effect on improving ACL recovery after reconstruction, but the difference in effect between OKC and CKC had not been found.