bluuebunny/crossref_metadata_2025_split huggingface dataset:
The function of astrocytes and their role in neurological diseases
Authors: Yuan Wen‐Qin , Huang Wei‐Peng , Jiang Yang‐Chao , Xu Hao , Duan Chong‐Shen , Chen Nai‐Hong , Liu Ying‐Jiao , Fu Xiao‐Mei 
Published: October 2023

AbstractAstrocytes have countless links with neurons. Previously, astrocytes were only considered a scaffold of neurons; in fact, astrocytes perform a variety of functions, including providing support for neuronal structures and energy metabolism, offering isolation and protection and influencing the formation, function and elimination of synapses. Because of these functions, astrocytes play an critical role in central nervous system (CNS) diseases. The regulation of the secretiory factors, receptors, channels and pathways of astrocytes can effectively inhibit the occurrence and development of CNS diseases, such as neuromyelitis optica (NMO), multiple sclerosis, Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease. The expression of aquaporin 4 in AS is directly related to NMO and indirectly involved in the clearance of Aβ and tau proteins in AD. Connexin 43 has a bidirectional effect on glutamate diffusion at different stages of stroke. Interestingly, astrocytes reduce the occurrence of PD through multiple effects such as secretion of related factors, mitochondrial autophagy and aquaporin 4. Therefore, this review is focused on the structure and function of astrocytes and the correlation between astrocytes and CNS diseases and drug treatment to explore the new functions of astrocytes with the astrocytes as the target. This, in turn, would provide a reference for the development of new drugs to protect neurons and promote the recovery of nerve function.
Arbitrage asymmetry, mispricing and the illiquidity premium
Authors: Wang Feifei , Zheng Lingling 
Published: October 2023

AbstractIlliquid assets require a return premium; illiquidity is also a limit‐to‐arbitrage. We find that Amihud's illiquidity premium is significantly higher among underpriced stocks than among overpriced stocks. Excluding the most mispriced stocks leads to a higher and more reliably estimated illiquidity premium. Amihud's illiquidity measure is positively correlated with overpricing, consistent with arbitrage asymmetry, while inconsistent with Lou and Shu's contention that the return premium associated with the Amihud measure reflects mispricing rather than compensation for illiquidity. Our results demonstrate that it is important to account for their role as limits‐to‐arbitrage when evaluating the pricing of illiquidity measures.
Momma's larvae: Maternal oceanographic experience and larval size influence early survival of rockfishes
Authors: Fennie H. William , Ben‐Aderet Noah , Bograd Steven J. , Kwan Garfield T. , Santora Jarrod A. , Schroeder Isaac D. , Thompson Andrew R. 
Published: October 2023

AbstractIdentifying factors that affect larval mortality is critical for understanding the drivers of fish population dynamics. Although larval fish mortality is high, small changes in mortality rates can lead to large changes in recruitment. Recent studies suggest maternal provisioning can dramatically affect the susceptibility of larvae to starvation and predation, the major sources of early‐life mortality. We measured otolith core width‐at‐extrusion and validated that this is a proxy for larval size‐at‐extrusion for eight species of rockfishes (genus Sebastes) to examine the influence of initial larval size on larval growth and survival and to understand how oceanographic conditions experienced by gestating females affect larval size (i.e., quality). Otolith core width‐at‐extrusion was significantly positively related to larval rockfish recent growth rate (5/7 species with sufficient sample size) and survival (all eight species). This suggests that individuals that are larger at extrusion generally grow faster and are more likely to survive early life stages. Otolith core width‐at‐extrusion was positively related to higher presence of Pacific Subarctic Upper Water and was negatively related to warmer, saline waters at the depths gestating mothers inhabited during the months prior to larval collection. In addition, otolith core width was larger further from fishing ports, possibly because these locations were historically less fished, contained more older, larger females, and/or had inherently better habitat quality (higher Pacific Subarctic Upper Water) than sites closer to shore. These results indicate that the environmental conditions female rockfish experience during gestation drive the size of the larvae they produce and impact larval growth and survival.
Convergence points of optimal herbage accumulation and intake rate by sheep grazing tall fescue
Authors: Szymczak Leonardo Silvestri , de Moraes Anibal , Sulc Reuben Mark , Barker David , Monteiro Alda Lucia Gomes , Lang Claudete R. , Moraes Renata Franciéli , Lemaire Gilles , de Faccio Carvalho Paulo César 
Published: October 2023

AbstractPasture management oriented towards sustainable intensification and stability of yield must consider the ideal balance between the mass of leaves removed by grazing and the mass left as residual. The former supports high animal production and the later supports an optimum soil–plant carbon balance. This study aimed to evaluate the optimal herbage level from both plant and animal perspectives, through the adjustment of instantaneous herbage accumulation rate as estimated by the Gompertz curve model and short‐term intake rate of sheep. Weekly tall fescue (Schedonorus arundinaceus) herbage accumulation was measured during seven growth periods with initiation dates in October, November and December 2015, and March, April, August and September 2016 and with the initiation dates arranged in a randomized complete block design with four replicates. Total herbage mass, leaf lamina mass, pseudo‐stem + sheath mass, senescent mass, and sward surface height were measured each week. The results demonstrated that a pre‐grazing sward surface height of 22.3 cm of tall fescue promoted the maximum short‐term intake rate of sheep and the optimum herbage accumulation rate in the spring and autumn periods. In general, the convergent point occurred after the maximum instantaneous leaf lamina accumulation rate and before the maximum instantaneous accumulation rate of pseudo‐stem + sheath and senescent material. We suggest the existence of a convergent point in which both primary and secondary production of pastoral ecosystems could be fostered.
Toward a more comprehensive shift‐share analysis: An illustration using regional data
Authors: Montanía Claudia V. , Márquez Miguel A. , Fernández‐Núñez Teresa , Hewings Geoffrey J. D. 
Published: October 2023

AbstractShift‐share analysis has been extensively used to investigate the different drivers of changes in socioeconomic variables in both spatial and non‐spatial contexts. This paper presents a comprehensive shift‐share formulation that, by considering all the possible interactions between the geographical and sectoral variables that interplay in a non‐spatial context, accounts for the intrinsic conditions of the regions that could affect the regional changes when spatial influences are not detected. The proposed technique is illustrated by analyzing the growth of industrial gross value added in the Spanish provinces between 2015 and 2019. Our results show the relevance of the intrinsic effects: the advantages (disadvantages) of the industrial sector within each province and the regional dynamism are important factors to explain the industrial changes in the Spanish regions. These findings provide evidence for the use of the comprehensive shift‐share as a tool that contribute to the regional analysis by identifying the characteristics of vulnerable regions that require further attention to avoid or lessen the effects of low economic growth.
My Wellbeing Journal: Development of a communication and goal‐setting tool to improve care for older adults with chronic conditions and multimorbidity
Authors: Lawless Michael T. , Archibald Mandy M. , Ambagtsheer Rachel C. , Pinero de Plaza Maria Alejandra , Kitson Alison L. 
Published: October 2023

AbstractBackgroundChronic conditions and multimorbidity, the presence of two or more chronic conditions, are increasingly common in older adults. Effective management of chronic conditions and multimorbidity in older adults requires a collaborative and person‐centred approach that considers the individual's goals, preferences and priorities. However, ensuring high‐quality personalised care for older adults with multimorbidity can be challenging due to the complexity of their care needs, limited time and a lack of patient preparation to discuss their personal goals and preferences with their healthcare team.ObjectiveTo codesign a communication and goal‐setting tool, My Wellbeing Journal, to support personalised care planning for older adults with chronic conditions and multimorbidity.DesignWe drew on an experience‐based codesign approach to develop My Wellbeing Journal. This article reports on the final end‐user feedback, which was collected via an online survey with older adults and their carers.Setting and ParticipantsOlder adults with chronic conditions, multimorbidity and informal carers living in Australia. Personalised care planning was considered in the context of primary care.ResultsA total of 88 participants completed the online survey. The survey focused on participants' feedback on the tool in terms of effectiveness, efficiency, satisfaction and errors encountered. This feedback resulted in modifications to My Wellbeing Journal, which can be used during clinical encounters to facilitate communication, goal setting and progress tracking.Discussion and ConclusionsClinicians and carers can use the tool to guide discussions with older adults about their care planning and help them set realistic goals that are meaningful to them. The findings of this study could be used to inform the development of recommendations for healthcare providers to implement person‐centred, goal‐oriented care for older adults with chronic conditions and multimorbidity.Patient or Public ContributionOlder adults living with chronic conditions and multimorbidity and their carers have contributed to the development of a tool that has the potential to significantly enhance the experience of personalised care planning. Their direct involvement as collaborators has ensured that the tool is optimised to meet the standards of effectiveness and usability.
Detection of wildtype Merkel cell polyomavirus genomic sequence and VP1 transcription in a subset of Merkel cell carcinoma
Authors: Kervarrec Thibault , Appenzeller Silke , Tallet Anne , Jullie Marie‐Laure , Sohier Pierre , Guillonneau Francois , Rütten Arno , Berthon Patricia , Le Corre Yannick , Hainaut‐Wierzbicka Ewa , Blom Astrid , Beneton Nathalie , Bens Guido , Nardin Charline , Aubin Francois , Dinulescu Monica , Visée Sebastien , Herfs Michael , Touzé Antoine , Guyétant Serge , Samimi Mahtab , Houben Roland , Schrama David 
Published: October 2023

AimsMerkel cell carcinoma (MCC) is frequently caused by the Merkel cell polyomavirus (MCPyV). Characteristic for these virus‐positive (VP) MCC is MCPyV integration into the host genome and truncation of the viral oncogene Large T antigen (LT), with full‐length LT expression considered as incompatible with MCC growth. Genetic analysis of a VP‐MCC/trichoblastoma combined tumour demonstrated that virus‐driven MCC can arise from an epithelial cell. Here we describe two further cases of VP‐MCC combined with an adnexal tumour, i.e. one trichoblastoma and one poroma.Methods and resultsWhole‐genome sequencing of MCC/trichoblastoma again provided evidence of a trichoblastoma‐derived MCC. Although an MCC‐typical LT‐truncating mutation was detected, we could not determine an integration site and we additionally detected a wildtype sequence encoding full‐length LT. Similarly, Sanger sequencing of the combined MCC/poroma revealed coding sequences for both truncated and full‐length LT. Moreover, in situ RNA hybridization demonstrated expression of a late region mRNA encoding the viral capsid protein VP1 in both combined as well as in a few cases of pure MCC.ConclusionThe data presented here suggest the presence of wildtype MCPyV genomes and VP1 transcription in a subset of MCC.
Hygienic maintenance in patients with maxillae atrophy and in oncological patients with maxillary resection rehabilitated with zygomatic implants: A nested monocentric prospective cohort study
Authors: Pellegrino Gerardo , Bertacci Angelica , Relics Daniela , Ferri Agnese , Grande Francesco , Felice Pietro 
Published: October 2023

AbstractObjectiveTo assess peri‐implant soft tissues condition, comparing clinical parameters of implants placed in patients with atrophic upper jaws and patients who underwent maxillary resection for oncological reasons.BackgroundZygomatic implants (ZIs) in oncologic patients could be affected by more complications compared to implants placed in atrophic maxillae. The soft tissue condition is an essential requirement for implant success, but few studies have investigated this topic.MethodsA nested monocentric prospective parallel cohort (atrophic vs. oncological patients) study was performed. Clinical visits and professional hygiene sessions were performed every three months, and bleeding on probing (BOP), probing pocket depth (PPD), gingival index (GI), plaque index (PI) and implant mobility were recorded by a blind outcome assessor.ResultsIn total, 77 ZIs placed in 21 patients were evaluated: 54 (70.1%) ZIs were inserted in patients belonging to the atrophic cohort (PAM) and 23 (29.9%) ZIs in the oncologic cohort (OP). The probability of having BOP at the considered mean follow‐up (27 months) was 24.8% (95% CI 19.0–31.9) for PAM and 22.9% (95% CI 15.1–33.9) OP. The mean PPD values were 2.78 ± 1.28 (range 1–8) in PAM and 2.91 ± 1.98 (range 0–10) in OP. None of the implants showed mobility. No associations between group belongingness and the entity of PPD, PI, GI and the risk of BOP were found, adjusting for the considered confounding factors (age, smoking and implant position).ConclusionsUnder a strict supportive hygiene therapy protocol ZIs in oncologic patients showed similar peri‐implant tissue conditions to that of patients with maxillary atrophy.
Study on the preparation of ceramic membrane support and its Fe migration rule by high‐aluminum fly ash as raw material
Authors: Zhang Jijun , Zhang Chao , Liu Xiuwu , Quan Liwei , Su Huhu , Hu Qi , Chen Xueqing 
Published: October 2023

AbstractIn order to reduce the cost of ceramic membrane support, ceramic membrane support was prepared using high‐aluminum fly ash as raw material, and its Fe migration rules during the preparation process are studied. The effects of sintering temperature, pore forming agent content, and binder content on the properties of support, such as porosity, pore size, bending strength and water flux have been investigated. The optimum contents of high‐aluminum fly ash, pore forming agent and binder in the ceramic membrane support are 95%, 4%, and 1% respectively, and its sintering temperature is 1300°C. The porosity, bending strength, pore size, and water flux of the prepared support are 37%, 22 MPa, 665 nm, and 2800 L/h·m2·MPa, respectively. X‐ray powder diffractometer, X‐ray fluorescence spectrometer, X‐ray photoelectron spectrometer, inductively coupled plasma spectrometer, transmission electron microscope, spherical aberration corrected transmission electron microscopy, and laser Raman spectroscopy were used to characterize the support and Fe existing morphology in it. The results show that the main phases of sintered support are mullite, corundum, and silica. Massive mullite is produced when the sintering temperature reaches 1200°C. The content of mullite increases with increasing sintering temperature. About 7.7 % content of total Fe in the support exists in the form of Fe2O3. About 92.3% content of total Fe is dissolved into mullite. Fe is evenly distributed in mullite, and it is enriched at the grain boundary by element segregation. Fe in mullite is difficult to dissolve under strong acid conditions, so its stability is very strong.
“Behind the Screen, I Still Care about my Students!”: Exploring the emotional labour of English language teachers in online teaching during the COVID‐19 Pandemic
Authors: Liu Honggang , Li Hanxi , Fang Fan 
Published: October 2023

AbstractForeign language teachers’ management of their emotional expression has a significant impact on their classroom teaching and professional development. As the demand for online education continues to grow, researchers are increasingly paying attention to the emotional situations of teachers in online teaching. However, there has been minimal research on secondary school English as a foreign language (EFL) teachers, particularly during the COVID‐19 pandemic when online teaching became the norm. By combining two lines of investigation, namely, emotional labour and emotion regulation, this study aimed to explore the emotional labour of EFL teachers in online teaching during the pandemic. As a qualitative case study, this research recruited 12 secondary school EFL teachers as participants. Drawing from semi‐structured interviews and reflective journals, this paper revealed the nuanced dilemma of EFL teachers’ emotional labour, the emotional rules they followed and the emotional regulation strategies they applied in their online teaching. This study also explored the complexity of the online learning environment in relation to EFL teachers’ emotional labour and analysed the characteristics of teachers’ emotional labour in online teaching compared to face‐to‐face classroom teaching. The findings confirmed that the change in the teaching situation affected teachers’ emotional labour and underlined the importance of self‐emotional management. At the end, this paper called for more attention to the emotional demands of online teaching to cultivate an emotionally healthy environment for EFL teachers.
Genomic monitoring of SARS‐CoV‐2 variants using sentinel SARI hospital surveillance
Authors: Denayer Sarah , Dufrasne François E. , Monsieurs Bert , van Eycken Reinout , Houben Sarah , Seyler Lucie , Demuyser Thomas , van Nedervelde Els , Bourgeois Marc , Delaere Bénédicte , Magerman Koen , Jouck Door , Lissoir Bénédicte , Sion Catherine , Reynders Marijke , Petit Evelyn , Dauby Nicolas , Hainaut Marc , Laenen Lies , Maes Piet , Baele Guy , Dellicour Simon , Cuypers Lize , André Emmanuel , Couvreur Simon , Brondeel Ruben , Barbezange Cyril , Bossuyt Nathalie , van Gucht Steven 
Published: October 2023

AbstractBackgroundTo support the COVID‐19 pandemic response, many countries, including Belgium, implemented baseline genomic surveillance (BGS) programs aiming to early detect and characterize new SARS‐CoV‐2 variants. In parallel, Belgium maintained a sentinel network of six hospitals that samples patients with severe acute respiratory infections (SARI) and integrated SARS‐CoV‐2 detection within a broader range of respiratory pathogens. We evaluate the ability of the SARI surveillance to monitor general trends and early signals of viral genetic evolution of SARS‐CoV‐2 and compare it with the BGS as a reference model.MethodsNine‐hundred twenty‐five SARS‐CoV‐2 positive samples from patients fulfilling the Belgian SARI definition between January 2020 and December 2022 were sequenced using the ARTIC Network amplicon tiling approach on a MinION platform. Weekly variant of concern (VOC) proportions and types were compared to those that were circulating between 2021 and 2022, using 96,251 sequences of the BGS.ResultsSARI surveillance allowed timely detection of the Omicron (BA.1, BA.2, BA.4, and BA.5) and Delta (B.1.617.2) VOCs, with no to 2 weeks delay according to the start of their epidemic growth in the Belgian population. First detection of VOCs B.1.351 and P.1 took longer, but these remained minor in Belgium. Omicron BA.3 was never detected in SARI surveillance. Timeliness could not be evaluated for B.1.1.7, being already major at the start of the study period.ConclusionsGenomic surveillance of SARS‐CoV‐2 using SARI sentinel surveillance has proven to accurately reflect VOCs detected in the population and provides a cost‐effective solution for long‐term genomic monitoring of circulating respiratory viruses.
Education policy reform and the impact of free preschool education on boys’ and girls’ reading competence
Authors: de Guevara Rodríguez María Ladrón , Lopez‐Agudo Luis Alejandro , Marcenaro‐Gutierrez Oscar David 
Published: October 2023

AbstractNumerous authors have reported a positive relationship between preschool enrolment and academic performance in later years, even helping to reduce the academic gap existing between students from different socio‐economic backgrounds. In this context, this paper goes further by analysing the impact that early childhood education (from 3 to 6 years) has on Spanish boys’ and girls’ reading achievement when they are in fourth grade (10 years). For this purpose, we take advantage of the 2006 Spanish education reform that promoted free second stage preschool education by using data from Progress in International Reading Literacy Study 2011 and 2016 and an instrumental variable approach, in order to get closer to causality than previous literature for Spain. We find that attending preschool has a positive influence on reading achievement, well above the impact found when using simple ordinary least squares estimates, being higher for girls than for boys.
A meta‐analysis of the risk factors of surgical site infection after hysterectomy for endometrial cancer
Authors: Yang Rong , Wang Lu , Shui ChengYu 
Published: October 2023

AbstractSurgical Site Infection (SSI) is one of the common postoperative complications after hysterectomy for endometrial cancer (EC). Previous studies have investigated the risk factors for SSI in patients with EC. However, big differences in research results exist, and the correlation coefficients of different research results are quite different. A meta‐analysis was conducted to examine the risk factors related to SSI in patients with EC. We searched English databases to collect case–control studies or cohort studies published before July 20, 2023, including PubMed, Web of Science, Embase and ScienceDirect. The risk of bias in the included studies was assessed via Newcastle–Ottawa Scale. The analysis was performed using RevMan 5.4.1 tool. A total of 6 articles (n = 3647) were selected in this meta‐analysis. The following risk factors were presented to be significantly correlated with SSI in EC: laparotomy (OR = 2.66, 95% CI [1.57, 4.54]), postoperative blood sugar ≥10 mmol/L (OR = 4.38, 95% CI [2.83, 6.78]), Federation International of Gynaecology and Obstetrics (FIGO) stage‐III or IV (OR = 2.27, 95% CI [1.49, 3.46]). The occurrence of SSI is influenced by a variety of factors. Thus, we should pay close attention to high‐risk subjects and take crucial targeted interventions to lower the SSI risk after hysterectomy. Owing to the limited quality and quantity of the included studies, more rigorous studies with adequate sample sizes are needed to verify the conclusion.