bluuebunny/crossref_metadata_2025_split huggingface dataset:
KECEMASAN SISWA SEKOLAH MENENGAH ATAS SAAT PEMBELAJARAN DARING DI TENGAH PANDEMI COVID-19
Authors: Mohammad Muhyidin  
Published: October 2023

Abstract: In March 2020 the Indonesian government imposed online learning from home for all school students as a social restriction effort during the COVID-19 pandemic. This study aims to determine the anxiety experienced by students and their efforts to overcome this anxiety. Ten informants from high school students were included in this study. They were given a questionnaire form containing open-ended questions related to the topic of this research. Data from filling out the questionnaire showed that there was studentsâ€™ anxiety when learning online from home which included difficulties in understanding the material, difficulties in carrying out assignments, problems with the internet network, technical problems, and a sense of worry about the next task. In overcoming this anxiety, they do things like the following, namely studying independently, every time doing a task immediately, discussing with teachers and friends, encouraging themselves, also carrying out other activities, among others, watching movies, listening to music, eating and exercising.
Keywordsâ€‹: â€‹â€‹ Anxiety, Online Learning, Covid-19
OPTIMASI PENJADWALAN PERAWAT DI RUANG UGD RSUD LAPANGAN SAWANG MENGGUNAKAN METODE NON-PREEMPTIVE GOAL PROGRAMMING
Authors: Lowryk O. Lahunduitan  , James U.L Mangobi  , Vivian E. Regar  
Published: October 2023

The emergency room which requires a full 24-hour nurse certainly needs to pay attention to the right schedule. To get an optimal schedule, it is necessary to divide nurses according to the needs of the right shift. Schedules that are made manually often violate or pay less attention to the applicable rules. Based on the existing rules in the hospital, constraints are divided into main constraints and additional constraints which are modeled and solved using the Non-Preemptive Goal Programming method with the objective function being to minimize the advantages or disadvantages of additional constraints. Furthermore, for the computational process assisted by the LINGO 19.0 application. From the results and discussion, it is found that the optimal schedule using the Non-Preemptive Goal Programming model is fulfilled for every existing constraint.
Keywords: Schedule, Nurse, Goal Programming, Non-Preemptive Goal Programming
OPTIMASI KEUNTUNGAN PADA HOME INDUSTRY ARYADY BAKERY MENGGUNAKAN LINEAR PROGRAMMING
Authors: Rangga R. Mandalika  , James U.L. Mangobi  , Marvel G. Maukar  
Published: October 2023

Home industry Aryady Bakery produces three types of bread, namely brown bread, cheese chocolate bread, and moca bread, but the profits are not maximized. In addition, the process of purchasing raw materials for making bread is carried out with estimates without definite calculations. Based on this, a production model is given in the form of linear programming to optimize profits in the Aryady Bakery Home industry. After observing and collecting data, the decision variables from this linear programming problem are obtained, namely the amount of brown bread, cheese and moca to be produced. In addition, the constraint functions for the model are obtained, namely raw materials, electricity, working hours of production machines, and labor hours, and the coefficients of the function variables on the objective function using the advantages of one brown bread, chocolate cheese bread, and moca bread. Furthermore, the profit optimization calculation process uses a linear program with a simple method with the help of LINDO and TORA software. The maximum yield obtained by producing as many as 4260 brown bread, 1200 cheese chocolate bread, and 500 moca bread each month is Rp. 3,600,460.
Keywords: Linear programming, Simpleks, Profit Optimization
LKPD SISTEM PEREDARAN DARAH BERBASIS PENDEKATAN SAINTIFIK
Authors: Qurrata Aâ€™yun  , Lina Arifah Fitriyah  
Published: October 2023

The circulatory system is closely related to human life. In this material, students are expected to know the parts of the heart organ related to activities with the frequency of the heartbeat. Characteristics of SMP/MTs class VIII students are able to use logic so that to study the material of the circulatory system, images that represent the existence of the circulatory system are needed, namely in the form of teaching materials using a scientific approach. The use of a scientific approach in the 2013 curriculum aims to create learning according to process standards. The purpose of this study was to describe the LKPD of the circulatory system based on a scientific approach based on its validity and practicality. The method used in this research is the ADDIE development model. The data of this study consisted of data on the validity and practicality of the developed LKPD. The results showed that the LKPD of the circulatory system based on a scientific approach was declared valid and practical.
Keywords: LKPD, Scientific Approaach, Circulatory System
VALIDITAS MEDIA TUAS PADA PEMBELAJARAN IPA MATERI PESAWAT SEDERHANA
Authors: Salafudin  , Noer Afâ€™idah  
Published: October 2023

Learning media is an important part of learning activities that serves to help convey messages from various learning sources in an effective and planned manner, so that learning objectives will be achieved. But so far, teachers rarely use learning media, so they have difficulty in conveying material to students. This causes learning activities to seem boring and students often have difficulty understanding the material. This problem usually occurs in materials that require a high level of understanding, such as simple plane materials, especially the discussion of levers. This study aims to develop lever media as a learning medium for VIII grade junior high school students on simple planes. This study uses the ADDIE development method which includes the analysis stage, the design stage, the development stage, the implementation stage, and the evaluation stage. The feasibility of the product developed in this study was obtained from the evaluation of the validation sheet by media expert validators and material experts, namely two science education lecturers at Hasyim Asy'ari University Tebuireng Jombang, and the practitioner validator, a science teacher from SMP Negeri 1 Jombang. From the assessment of the validation sheet obtained results in the form of qualitative and quantitative data. Qualitative data in the form of suggestions and input are used as a reference to improve and revise the lever media developed. While the quantitative data is processed to get the value of the validity of the developed lever media. Based on the results of the lever media validation assessment, it was obtained an average score of 3.82 in the very good category and a validity score of 95.5% in the very valid category.
Keywordsâ€‹: â€‹â€‹ Learning Media, Lever Media, Simple Plane
IMPLEMENTASI MODEL THINK TALK WRITE (TTW) DALAM PENINGKATAN HASIL BELAJAR SISWA MATERI PROCEDURE TEXT
Authors: Lies Muhsonati  
Published: October 2023

The purposes of this study are to describe (1) the implementation of the Learning Implementation Plan during the learning process, (2) the learning outcomes of the product after the implementation of Think Talk Write, (3) student activities during the implementation of the Think Talk Write, and (4) students' responses to learning by applying the Think Talk Write learning model. This classroom action research was carried out for two cycles in class X MIPA 2 SMA Negeri 1 Puri involving 35 students. Each cycle consists of stages of planning, implementation, observation and reflection. The results showed that (1) the learning process by applying the Think Talk Write learning model could be carried out in good categories, namely in the first cycle with a value of 3.03 and the second cycle of 3.27., (2) student activities during the application of the Think Talk Write learning model showed students active with an activeness of 87.15% in the first cycle and 93.48% in the second cycle, (3) character behavior in both cycles showed good behavior with an average score of 3.23 (good) in the first cycle and 3.45 (good) in the second cycle, (4) results student learning after the implementation of the Think Talk Write learning model has increased with the percentage of completeness 77.14% in the first cycle increasing to 91.4% in the second cycle, and (5) student responses to learning by applying the Think Talk Write learning model are positive
Perawatan Mesin SNS Cutter di PT.XYZ
Authors: Daniel Irfan 
Published: October 2023

Penggunaan produk dari kaca di sektor industri mengalami peningkatan dikarenakan kaca banyak digunakan pada bangunan, dan automotive. Produksi kaca pada PT. XYZ memiliki sistem yang baik dari segi sumber daya manusia dan produk. Kaca yang mengalami kecacatan juga dapat diolah kembali sehingga mengurangi kerugian pada produksi dalam perusahaan kaca ini. Produksi yang baik juga disebabkan oleh mesin yang baik pula, sehingga mesin yang ada pada perusahaan ini harus di rawat dengan baik agar tidak terjadi hambatan proses produksi oleh karena mesin rusak dan lain sebagainya. Penelitian ini berfokus pada mesin sns cutter karena mesin ini memiliki peran penting dalam pemotongan kaca untuk memenuhi kepuasaan konsumen dalam berbagai ukuran. Mesin sns cutter ini memiliki macam-macam cara perawatan, memiliki berbagai spare part yang ada pada mesin sehingga harus dilakukan pengecekan secara berkala. Jenis-jenis perawatan yang ada pada mesin sns cutter, proses produksi dari kaca terbentuk sampai dipotong sesuai dengan keinginan konsumen, penyebab kerusakan mesin. Berdasarkan penelitian ini diketahui penyebab seringnya mesin mengalami kerusakan jika minyak tidak optimal sehingga pisau pada mesin cutter mengalami tumpul dan menyebabkan potongan kaca tidak maksimal. Perawatan pada mesin ini dilakukan dalam harian, mingguan, dan bulanan.
Novel role for alpha-2-macroglobulin (A2M) as a disease modifying protein in senile osteoporosis
Authors: Boregowda Siddaraju V. , Haga Christopher L. , Supper Valentina M. , Booker Cori N. , Phinney Donald G. 
Published: October 2023

Introduction: In the rapidly aging U.S. population, age-induced bone loss (senile osteoporosis) represents a major public health concern that is associated with a significant increased risk for low trauma fragility fractures, which are debilitating to patients, cause significant morbidity and mortality, and are costly to treat and manage. While various treatments exist to slow bone loss in osteoporosis patients, these suffer from poor tolerability and label restrictions that limit their overall effectiveness. Over the past decade, skeletal stem/progenitor cells (SSPCs), which are the main precursor of osteoblasts and adipocytes in adult bone marrow (BM), have emerged as important players in osteoporosis.Methods: Age-induced skeletal pathology was quantified in elderly (24-month-old) vs. mature (3-month-old) mice by micro-CT and changes in SSPC abundance in the BM of these mice was quantified by fluorescence-activated cell sorting (FACS). SSPCs from elderly vs. mature mice were also analyzed by RNA-Seq to identify differentially expressed genes (DEGs), and gain and loss-of-function studies were performed in human BM-derived mesenchymal stromal cells (BM-MSCs) to assess A2M function.Results: Elderly mice were shown to exhibit significant age-induced skeletal pathology, which correlated with a significant increase in SSPC abundance in BM. RNA-seq analysis identified alpha-2-macroglobulin (A2M), a pan-protease inhibitor that also binds inflammatory cytokines, as one of the most downregulated transcripts in SSPCs isolated from the BM of elderly vs. mature mice, and silencing of A2M expression in human BM-MSCs induced their proliferation and skewed their lineage bifurcation toward adipogenesis at the expense of osteogenesis thereby recapitulating critical aspects of age-induced stem cell dysfunction.Conclusion: These findings identify A2M as a novel disease modifying protein in osteoporosis, downregulation of which in bone marrow promotes SSPC dysfunction and imbalances in skeletal homeostasis.
Comparative analysis of clinical and immunological profiles across Omicron BA.5.2 subvariants using next-generation sequencing in a Chinese cohort
Authors: Huang Jianliang , Xia Mingkai , Liu Rangjiao , Wang Shaobo , Duan Xinyi , Peng Jiong , Li Enping , Zhou Yanping , Li Chengyou , Zhang Quan , Tian Jixian , Wang Xinjian , Su Zhongrui , Tan Jun , Peng Bo , Zhang Jianhui , Li Jin , Dai Lizhong , Lei Mingsheng 
Published: October 2023

ObjectiveThe Omicron BA.5.2 variant of SARS-CoV-2 has undergone several evolutionary adaptations, leading to multiple subvariants. Rapid and accurate characterization of these subvariants is essential for effective treatment, particularly in critically ill patients. This study leverages Next-Generation Sequencing (NGS) to elucidate the clinical and immunological features across different Omicron BA.5.2 subvariants.MethodsWe enrolled 28 patients infected with the Omicron variant, hospitalized in Zhangjiajie People’s Hospital, Hunan, China, between January 20, 2023, and March 31, 2023. Throat swabs were collected upon admission for NGS-based identification of Omicron subvariants. Clinical data, including qSOFA scores and key laboratory tests, were collated. A detailed analysis of lymphocyte subsets was conducted to ascertain the extent of immune cell damage and disease severity.ResultsPatients were infected with various Omicron subvariants, including BA.5.2.48, BA.5.2.49, BA.5.2.6, BF.7.14, DY.1, DY.2, DY.3, and DY.4. Despite having 43 identical mutation sites, each subvariant exhibited unique marker mutations. Critically ill patients demonstrated significant depletion in total lymphocyte count, T cells, CD4, CD8, B cells, and NK cells (P &lt; 0.05). However, there were no significant differences in clinical and immunological markers across the subvariants.ConclusionThis study reveals that critically ill patients infected with different Omicron BA.5.2 subvariants experience similar levels of cellular immune dysfunction and inflammatory response. Four mutations - ORF1a:K3353R, ORF1a:L3667F, ORF1b:S997P, S:T883I showed correlation with immunological responses although this conclusion suffers from the small sample size. Our findings underscore the utility of NGS in the comprehensive assessment of infectious diseases, contributing to more effective clinical decision-making.
Symptomatic periesophageal vagal nerve injury by different energy sources during atrial fibrillation ablation
Authors: Miyazaki Shinsuke , Kobori Atsushi , Jo Hikari , Keida Takehiko , Yoshitani Kazuyasu , Mukai Moe , Sagawa Yuichiro , Asakawa Tetsuya , Sato Eiji , Yamao Kazuya , Horie Tomoki , Manita Mamoru , Fukaya Hidehira , Hayashi Hidemori , Tanimoto Kojiro , Iwayama Tadateru , Chiba Suguru , Sato Akinori , Sekiguchi Yukio , Sugiura Kenta , Iwai Shinsuke , Isonaga Yuhei , Miwa Naoyuki , Kato Nobutaka , Inaba Osamu , Hirota Takayoshi , Nagata Yasutoshi , Ono Yuichi , Hachiya Hitoshi , Yamauchi Yasuteru , Goya Masahiko , Nitta Junichi , Tada Hiroshi , Sasano Tetsuo 
Published: October 2023

BackgroundSymptomatic gastric hypomotility (SGH) is a rare but major complication of atrial fibrillation (AF) ablation, but data on this are scarce.ObjectiveWe compared the clinical course of SGH occurring with different energy sources.MethodsThis multicenter study retrospectively collected the characteristics and clinical outcomes of patients with SGH after AF ablation.ResultsThe data of 93 patients (67.0 ± 11.2 years, 68 men, 52 paroxysmal AF) with SGH after AF ablation were collected from 23 cardiovascular centers. Left atrial (LA) ablation sets included pulmonary vein isolation (PVI) alone, a PVI plus a roof-line, and an LA posterior wall isolation in 42 (45.2%), 11 (11.8%), and 40 (43.0%) patients, respectively. LA ablation was performed by radiofrequency ablation, cryoballoon ablation, or both in 38 (40.8%), 38 (40.8%), and 17 (18.3%) patients, respectively. SGH diagnoses were confirmed at 2 (1–4) days post-procedure, and 28 (30.1%) patients required re-hospitalizations. Fasting was required in 81 (92.0%) patients for 4 (2.5–5) days; the total hospitalization duration was 11 [7–19.8] days. After conservative treatment, symptoms disappeared in 22.3% of patients at 1 month, 48.9% at 2 months, 57.6% at 3 months, 84.6% at 6 months, and 89.7% at 12 months, however, one patient required surgery after radiofrequency ablation. Symptoms persisted for &gt;1-year post-procedure in 7 patients. The outcomes were similar regardless of the energy source and LA lesion set.ConclusionsThe clinical course of SGH was similar regardless of the energy source. The diagnosis was often delayed, and most recovered within 6 months, yet could persist for over 1 year in 10%.
Endophyte-inoculated rhizomes of Paris polyphylla improve polyphyllin biosynthesis and yield: a transcriptomic analysis of the underlying mechanism
Authors: Zhang Qing , Chang Sheng , Yang Ying , Xi Congfang , Dong Yumei , Liu Lufeng , He Yunchao , Liu Yu , Cai Bo , Liu Tao 
Published: October 2023

IntroductionPolyphyllin from Paris polyphylla var. yunnanensis exhibits anti-inflammatory, analgesic, antibacterial, and antiviral properties. However, the current production of polyphyllin can barely meet market demand. To improve the content of polyphyllin produced by P. polyphylla, two endophyte strains, Bacillus cereus LgD2 and Fusarium oxysporum TPB, were isolated from Paris fargesii Franch. and inoculated in the roots of P. polyphylla. Both symbiotic strains significantly promoted the accumulation of saponins in P. polyphylla.MethodsThe content of polyphyllin in rhizomes of P. polyphylla treated with TPB with LgD2 strain was determined using High Performance Liquid Chromatography and the expressed genes were analyzed by RNA-seq. Gene Ontology and Kyoto Encyclopedia of Genes annotations were performed on the differentially expressed genes, a clustering tree of UDP-glycosyltransferase (UGT) and cytochrome P450 (CYP450) gene families was constructed, and UGT and CYP450 involved in the biosynthesis of polyphyllin were predicted using weighted correlation network analysis (WGCNA).ResultsRNA-seq and qRT-PCR analyses showed that endophytic inoculation did not promote polyphyllin accumulation by enhancing the upstream terpene biosynthesis pathway, but probably by up-regulating the downstream CYP450 and UGT genes associated with polyphyllin biosynthesis. Genomes enrichment analyses of differentially expressed genes indicated that inoculation with LgD2 and TPB played a positive role in promoting the defense against pathogenic bacteria, enhancing the biosynthesis of carbohydrates, attenuating the process of nitrogen metabolism, and maintaining the equilibrium of the redox reaction homeostasis, potentially indirectly enhancing the polyphyllin yield of P. polyphylla. By combining differentially expressed genes screening, WGCNA, and phylogenetic tree analyses, 17 CYP450 and 2 UGT candidate genes involved in the biosynthesis of polyphyllin I, polyphyllin II, polyphyllin VII, polyphyllin D, and polyphyllin H were identified. These results suggest that endophytes probably effectively promote the accumulation of polyphyllin by regulating key downstream genes in biosynthetic pathways.DiscussionThis study provides a new approach for investigating the regulatory mechanisms of endophytes that promote the production and accumulation of polyphyllin in P. polyphylla, providing a basis for further elucidating the mechanisms of plant-endophyte interactions.
Structural and connectivity parameters reveal spared connectivity in young patients with non-progressive compared to slow-progressive cerebellar ataxia
Authors: Marchese Silvia Maria , Palesi Fulvia , Nigri Anna , Bruzzone Maria Grazia , Pantaleoni Chiara , Gandini Wheeler-Kingshott Claudia A. M. , D’Arrigo Stefano , D’Angelo Egidio , Cavallari Paolo 
Published: October 2023

IntroductionWithin Pediatric Cerebellar Ataxias (PCAs), patients with non-progressive ataxia (NonP) surprisingly show postural motor behavior comparable to that of healthy controls, differently to slow-progressive ataxia patients (SlowP). This difference may depend on the building of compensatory strategies of the intact areas in NonP brain network.MethodsEleven PCAs patients were recruited: five with NonP and six with SlowP. We assessed volumetric and axonal bundles alterations with a multimodal approach to investigate whether eventual spared connectivity between basal ganglia and cerebellum explains the different postural motor behavior of NonP and SlowP patients.ResultsCerebellar lobules were smaller in SlowP patients. NonP patients showed a lower number of streamlines in the cerebello-thalamo-cortical tracts but a generalized higher integrity of white matter tracts connecting the cortex and the basal ganglia with the cerebellum.DiscussionThis work reveals that the axonal bundles connecting the cerebellum with basal ganglia and cortex demonstrate a higher integrity in NonP patients. This evidence highlights the importance of the cerebellum-basal ganglia connectivity to explain the different postural motor behavior of NonP and SlowP patients and support the possible compensatory role of basal ganglia in patients with stable cerebellar malformation.
Integrated proteomics and metabolomics analysis of D-pinitol function during hippocampal damage in streptozocin-induced aging-accelerated mice
Authors: Li Xiaoxia , Gao Yuan , Li Baoying , Zhao Wenqian , Cai Qian , Yin Wenbin , Zeng Shudong , Li Xiaoli , Gao Haiqing , Cheng Mei 
Published: October 2023

PurposeDiabetes can cause hippocampal damage and lead to cognitive impairment. Diabetic cognitive impairment (DCI) is a chronic complication of diabetes associated with a high disability rate; however, its pathogenesis and therapeutic targets are unclear. We aimed to explore the mechanism of hippocampal damage during diabetes and evaluate the potential role of D-pinitol (DP) in protecting hippocampal tissue and improving cognitive dysfunction.MethodsDP (150 mg/kg/day) was administered intragastrically to streptozocin-induced aging-accelerated mice for 8 weeks. Hippocampal tissues were examined using tandem mass tag (TMT)-based proteomics and liquid chromatography-mass spectrometry (LC–MS)/MS-based non-targeted metabolomic analysis. Differentially expressed proteins (DEPs) and differentially regulated metabolites (DRMs) were screened for further analysis, and some DEPs were verified using western blotting.ResultsOur results showed that 329 proteins had significantly altered hippocampal expression in untreated diabetic mice (DM), which was restored to normal after DP treatment in 72 cases. In total, 207 DRMs were identified in the DM group, and the expression of 32 DRMs was restored to normal post-DP treatment. These proteins and metabolites are involved in metabolic pathways (purine metabolism, arginine and proline metabolism, and histidine metabolism), actin cytoskeleton regulation, oxidative phosphorylation, and Rap1-mediated signaling.ConclusionsOur study may help to better understand the mechanism of diabetic hippocampal damage and cognitive impairment and suggest a potential therapeutic target.