bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-alcoholic fatty liver disease and type 2 diabetes mellitus: diagnostic and therapeutic aspects. Review
Authors: Bentsa T. M. 
Published: December 2023

The increase in the prevalence of non‑alcoholic fatty liver disease (NAFLD) occurs in parallel with the global epidemic of obesity and type 2 diabetes mellitus (T2DM) in the world. T2DM is an independent risk factor for the development of NAFLD. At the same time, researchers found that patients diagnosed with NAFLD have a two‑fold increased risk of developing T2DM. NAFLD is encompasses a spectrum of liver manifestations ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, which may ultimately progress to hepatocellular carcinoma. NASH is an aggressive form of NAFLD, associated with an increased risk of liver and non‑liver‑related mortality. Liver‑biopsy remains the gold standard for diagnosis, but the majority of patients liver damage can be diagnosed accurately by noninvasive methods.
The presence of NAFLD in a patient with T2DM makes it difficult to achieve adequate glycemic control, deepens the manifestations of insulin resistance and atherogenic dyslipidemia, increases the risk of serious cardiovascular events and chronic kidney disease. Lifestyle modification and treatment of concomitant T2DM should be undertaken in all patients with NAFLD. To reduce the severity of liver steatosis, weight reduction by 3—5% is necessary, to reduce the inflammatory‑necrotic process, a more significant reduction may be required — up to 10% within 6—12 months. Physical activity increases the sensitivity of insulin receptors, and in combination with diet leads to a significantly significant improvement in biochemical and histological indicators in patients with NAFLD. Early identification and management of patients with intensive dietary and lifestyle modification are essential to prevent the development of advanced liver disease and its complications. Pharmacological therapy should be administered to patients with NASH purposed on the fibrosis inhibition, especially in case of the established predictors of high risk of disease progression (age >50 years, metabolic syndrome, T2DM, or increase in the activity of alanine aminotransferase), as well as to the patients with active NASH with high inflammatory activity.
At the congress of the European Association for the Study of the Liver (EASL), which took place in Vienna on June 21—24, 2023, a new classification and nomenclature of NAFLD was adopted. It was proposed to replace the term «non‑alcoholic fatty liver disease» to the term «metabolic dysfunction‑associated steatotic liver disease» (MASLD). This diagnosis is established in patients with confirmed steatosis of the liver and one of five cardiometabolic risk factors: obesity, T2DM, insulin resistance, hyperlipidemia, atherosclerosis. The concept of «non‑alcoholic steatohepatitis» (NASH) has been changed to the concept of «metabolic dysfunction‑ associated steatohepatitis» (MASH). Coordination of the views of international and domestic experts in the field of studying this pathology will be important for clinical practice and scientific research.
Domestic researchers who have made important contributions to the study of digestive system diseases: images in art. Iryna Ivanivna Degtyareva
Authors: Gubergrits N. B. 
Published: December 2023

In her article, the author does not provide biographical data of Professor Iryna Ivanovna Degtyareva, but shares thoughts, feelings, memories about the Teacher. Iryna Ivanivna Degtyareva was an outstanding person in every aspect. The author was amazed by her remarkable appearance when she first met her in 1976. She was a striking lady who captivated by her charm, talent, and, most importantly, professionalism. Then, Iryna Ivanivna was appointed as a reviewer of the candidate’s dissertation by N. B. Gubergrits before approbation. Iryna Ivanivna spent almost the whole day with N. B. Gubergrits, a young physician who had just graduated from a medical university, since it was her first time meeting her. The two of them sat until late at the department of faculty therapy of the Kyiv Medical Institute, where Iryna Ivanivna worked at the time. Her remarks were undoubtedly well‑grounded. However, Iryna Ivanivna did not only provide criticism; she offered instant guidance on how to fix errors and avoid “sharp edges”, all the while pointing out the advantages of the work. Then, like lately, everything was fair. Inflexibility accompanied this justice. Iryna Ivanivna’s first major lesson was to work hard and overcome barriers in the pursuit of truth and results. This extraordinary lady and scientist had a great intellect, tolerance for students’ mistakes, total loyalty to them, and unwavering determination to work with them. N. B. Gubergrits sought Professor Iryna Ivanivna Degtyareva’s consultation for her doctoral dissertation as a result. Iryna Ivanivna’s brilliant mind «burst out» with ideas that she genuinely shared with her students. The contribution of Iryna Ivanivna to the doctoral dissertation of N. B. Gubergrits and her title of professor are enormous. Much has been achieved with her help. Iryna Ivanivna took great pride in her students, including Ihor Mykolayovych Skrypnyk, Mykhaylo Yuriyovych Kolomoyets, and Natalya Vyacheslavivna Kharchenko. To her, they were more than just students. She looked after them in life as well as in science. Many clinicians use Iryna Ivanivna’s monographs as reference textbooks, including «Clinical Gastroenterology» and «Peptic Ulcer».
The problem of strategic human resource management in healthcare in Poland
Authors: Dubrovina N. , Kolesnikova O. , Siwiec A. , Dubrovina V. , Radchenko A. 
Published: December 2023

Objective — to study the basic principles of the strategic human resource management in healthcare, to analyze the features of human resource management in healthcare organizations, to analyze the long‑term trends of the human resources in the healthcare in Poland and to propose the recommendations for the implementation of measures for strategic human resources management in healthcare organizations.
Results. The problems of the long‑term and short‑term tendencies of human resources in the healthcare in Poland are discussed in the article. The age, gender and regional distribution of the human resources in the healthcare are shown and the main factors influenced on the dynamics of these indicators are described. Taking into account different problems in the healthcare in Poland the importance of the strategic human resource management is presented and the general recommendations for health institutions are given.
Conclusions. Strategic management and analysis of human resources development are crucial in Polish healthcare. Health institutions need strategic plans and performance assessments for medical facilities. The expanded strategic management of medical organizations involves assessing both the external and internal environment, considering macroeconomic changes, regional shifts, market dynamics, mobility, qualifications, motivation of medical personnel, and evaluating the organization’s image among patients and public entities. In strategic human resources analysis, key factors include strategic intentions, forecasting challenges, positioning, and prioritizing human resources management. Given the complex macro environment of medical organizations, it’s crucial to identify the most significant factors, evaluate their potential impact, and formulate response measures within the organization’s strategy.
The difficulty of revascularization at myocardial infarction with ST-segment elevation during the military conflict: clinical scenarios. Review
Authors: Kopytsya M. P. , Petyunina O. V. , Vyshnevska I. R. 
Published: December 2023

Russian military aggression against Ukraine challenged serious difficulties in the treatment of acute myocardial infarction with ST segment elevation (STEMI). Continuous stress, depression and insufficient pharmacotherapy resulted in the chronic coronary syndrome exacerbation, the increased number of STEMI cases and increased mortality because of the absence of timely myocardial reperfusion. The golden standard of the STEMI treatment is percutaneous coronary intervention (PCI), the result of which is the most effective reperfusion and patients’ survival. At the military conditions PCI possibility is restricted. The alternative to this method should be the fibrinolytic therapy, which has recently been rarely used as a reperfusion method in acute STEMI due to the availability of a network of catheter laboratories. The optimal variant of treatment at the condition of complicated logistical circumstances during the military time must be pharmacoinvasive strategy based on fibrinolysis and further PCI. Since the capabilities of reperfusion centers differ in the regions of Ukraine depending on the distance from the war zone, treatment strategies may be different. The main task in the STEMI treatment always must be the earliest renovation of myocardial circulation in the ischemic myocardium.
The authors highlighted scenarios of STEMI treatment at the condition of military conflict where pharmacoinvasive strategy might have advantages in case of difficulties with providing quick access to percutaneous coronary intervention.
When choosing a treatment strategy for acute STEMI, it is important to consider the specific conditions, the resources of the medical system, and the availability of medical care. The use of pharmacoinvasive strategy may be useful if the initial PCI is delayed beyond the recommended time, allowing for early reperfusion and improving treatment outcomes.
Physiological impact of heat stress and their alleviation measures in agriculture: A review
Authors: Jayara Alok Singh , Pant Chayan , Singh Sampurna Nand , Shukla Pavan , Singh Shubham , Pandey Sharad 
Published: December 2023

Abiotic stresses are becoming more prevalent in modern agriculture as a result of shifting climate scenarios. Elevated temperature stress is one of the most important abiotic stresses to address since it has detrimental consequences for plant physiology, molecular structure, and phenology. The morphological impact occurs in the form of reduced germination, poor emergence, poor seedling vigor, abnormal seedling. Heat stress also results in the closure of stomata, reduced leaf size and consequent increase in stomatal density. One of the major physiological impacts of heat stress is on the fluidity of the membrane structure of the plant cell. Heat stress leads to increased fluidity of the thylakoid membrane and disruption of metabolic functions, which either deliver or accept electrons from PSII and, thus, cause dislodging of PSII from thylakoid membrane. The respiration generally increases in the temperature range of 0-35/ 40⁰C, reaches plateau at 40-50⁰C and decreases beyond 50⁰C due to damage to the respiratory mechanism. Elevated temperature directly impacts the cellular water content and indirectly through the increased water depletion rate from the soil. In order to design the appropriate corrective actions, it is crucial to research all the factors leading to heat stress thoroughly. The traditional agronomic and breeding interventions are crucial, but the rising food demand and the intensifying heat stress call for some cutting-edge biotechnological interventions, such as transgenics, genome editing, and CRISPR/cas9, to induce genome-level heat tolerance. The present review deals in detail with each of the previously listed aspects.
A Biopesticides and their impact on brinjal Jassid (Amrasca biguttula biguttula Ishida)
Authors: L.S. Bhushan , Raut A. M. , Talekar Nilesh , Chaudhary Bishal , Sonawane Vishal , A Ashwini 
Published: December 2023

Brinjal (Solanum melongena) is a precious and nourishing vegetable grown worldwide in tropical and subtropical climates. Jassid (Amrasca biguttula biguttulaI.) (Hemiptera: Cicadellidae),of which nymphs and adults suck the cell sap from the underside of the brinjal leaves resulting in curling and affecting the photosynthesis process. The present study aimed to study the effectiveness of biopesticides and their impact on jassid and its natural enemy in different seasons. The field experiment arranged in randomized block design includes six biorational insecticides such has (T1)-Spinosad 45 % SC @ 0.4ml/l, (T2)-Neem Seed Kernel Extract(NSKE) 1% @ 2ml/l, (T3)-Beauveria bassiana 1x 108 @ conidia/ml @ 10ml/l, (T4)-Metarhizium anisopliae1x 108 conidia/ml @ 10ml/l, (T5)-Verticillium lecanii 1x108 conidia/ml @ 10ml/land (T6)-Untreated plots replicated in four times. It is resulted that all the biorational pesticides performed significantly better than the control. However, among the treatments, application of (T3)-Beauveria bassiana 1x108 conidia/ml @ 10 ml/l and (T2)-Neem Seed Kernel Extract (NSKE) 1% @ 2 ml/l was found to have significantly better results against jassid,during Rabi(2021) and Kharif season (2022) respectively. For predatory coccinellids,(T2) - Neem Seed Kernel Extract (NSKE) 1% @ 2 ml/l and(T1)-Spinosad 45 % SC @ 0.4ml/l were found to be better compared to other treatments in Rabi and Kharif season. This research will help to understand the importance of biopesticides with eco-friendly approaches to manage jassid.
Efficient Deep Learning model for de-husked Areca nut classification
Authors: Patil Sameer , Naik Aparajita , Parab Jivan 
Published: December 2023

Areca nut is a widely used agricultural product in India and even over the globe. Areca nut, a fruit of areca palm (Areca catechu) is grown widely in the Asia-Pacific region.. Areca nut segregation is of prime importance in the areca nut industry. The quality segregation of peeled/de-husked nuts requires skilled workers. This process of manual segregation is time-consuming and can lead to erroneous classification. Recent deep learning (DL) advances have improved the performance in multi-class problems. The present work presents the classification of de-husked areca nut among five classes using an efficient deep learning customized Convolutional Neural Network (CNN) and the results of this model were compared with the standard AlexNet architecture. The new CNN model was customized to obtain classification accuracy higher than the existing ones. A dataset of 300 nuts (60 per class) was created using a specially designed instrumentation setup. The areca nut images were then pre-processed and fed to these models to learn the features of the areca nut from different classes. The confusion matrix and Area Under the Curve - Receiver Operating Characteristics (AUC- ROC) were employed to assess the results of these models and cross-validated with 5 and 10-fold. The experimental results show that the CNN outperformed the AlexNet model with an average accuracy of 97.33% and 98.34%, F1 score of 97.48%, and 98.45% for 5 and 10 folds, respectively.
Treatment of textile effluent by using Burflower tree (Neolamarckia cadamba) leaf powder: Batch biosorption study
Authors: Talukdar Seema , Sarma Hari Prasad 
Published: December 2023

The textile industry is one of the leading causes of major environmental problems worldwide. The textile dye effluents hold diverse kinds of dyes along with other contaminants. Various environmental legislations have been formulated and obligate the textile industries to treat the effluents prior to discharge into water bodies. The present study aimed to evaluate the efficacy of removing two dyes, Congo red and Methylene blue, present in raw textile effluent by employing the powdered leaves of the Burflower (Neolamarckia cadamba) tree as adsorbent. The experiment was performed in a laboratory scale. The surface characterization of the adsorbent was carried out using Brunauer-Emmett-Teller (BET) surface area analysis, CHN elemental analyzer, FTIR and SEM-EDX analyses. The effluent was characterised before and after the biosorption process to check the efficiency of the process on the various parameters of the effluent. The values of the examined parameters were found to be decreased after the adsorption process. The removal percentages of the two dyes (Congo red = 76.35% and Methylene blue = 85.8%) using the adsorbent were also estimated by batch experiment studies. The findings of this study infer that the adsorbent as mentioned above, can be used to treat dye effluents.
Sebuah Studi Pengembangan Bentuk Sediaan Obat : Olsalazine Sebagai Colonic Drug Targeting
Authors: Taufikurrahman Taufikurrahman 
Published: December 2023

Penyakit inflamasi usus (IBD) merupakan kondisi yang mempengaruhi sistem pencernaan dan dapat menyebabkan gejala seperti diare, sakit perut, dan penurunan berat badan. IBD terdiri dari dua jenis yaitu colitis ulserativa dan penyakit Crohn. Kedua jenis IBD disebabkan oleh respon sistem kekebalan tubuh yang tidak tepat terhadap bakteri usus normal dan kemudian menyebabkan peradangan pada usus. Pengobatan IBD tergantung pada tingkat keparahan dan jenis penyakit.
Olsalazine, suatu prodrug salisilat, telah digunakan secara luas untuk mengobati colitis ulseratif dan ditemukan memiliki efek samping yang lebih sedikit dibandingkan dengan sulfasalazine, obat yang serupa. olsalazine diserap dengan cepat dalam usus halus dan kemudian diubah menjadi dua molekul asam salisilat. Namun, hanya sebagian kecil dari asam salisilat ini yang mencapai usus besar, di mana colitis ulseratif paling sering terjadi.
Salah satu pendekatan yang diusulkan adalah dengan menggunakan olsalazine sebagai colonic drug targeting. Pada pendekatan ini, olsalazine dimodifikasi dengan pengikat yang spesifik untuk sel epitel usus besar, sehingga obat tersebut dapat diantarkan langsung ke daerah yang terkena penyakit. Dari absorpsi dan ekskresi 5-ASA terjadi sangat cepat dan intensif sehingga didapatkan total 5-ASA yang tinggi di urin. Penggunaan 5-ASA (tanpa modifikasi senyawa atau formula) sebagai terapi IBD tidak akan efektif karena jumlah obat yang akan sampai ke kolon akan kecil. Sedangkan penggunaan Olsalazine dengan diformulasi menjadi tablet konvensional efektif sebagai terapi IBD karena olsalazine sangat sedikit diabsorpsi di lambung dan usus halus. Kajian selanjutnya tentang olsalazine sebagai colonic drug targeting dapat membuka pintu bagi pengembangan obat yang lebih efektif dan efisien dalam pengobatan IBD.
Philharmonic (concert) hall as a component of the infrastructure of musical life
Authors: Chekan Yurii 
Published: December 2023

Relevance of the study. The study of the infrastructure of musical life is a very important part of modern historical musicology. In this essay, I summarized information about philharmonic (concert) halls. These locations are the basic components of the musical life infrastructure.
The purpose of the study. The main goal of the research is to reveal the fundamental differences between the philharmonic hall and the opera house (at the stage of its formation), the ways of evolution and the factors that led to the transformation of the philharmonic (concert) hall in our time. The goal defined in this way determines a set of local tasks, the solution of which will allow it to be achieved. This is, in particular, a parametric, morphological and functional comparison of the philharmonic and opera halls; determination of the direction and dynamics of the object's evolution until the moment of stabilization; historical and cultural factors that influenced the change in the configuration and functioning of the hall in the second half of the 20th - the first decades of the 21st century. Research methods are determined by the set goal and tasks and include both a quantitative approach (for parametric characterization of objects) and comparative and historical-cultural types of analysis.
The results and conclusions. Appearing a century later than publicly accessible opera houses, a philharmonic became a stage of stabilization of the new European intonation concept. Belonging to the enterprises of the artistic sphere, it was influenced by the processes of democratization caused by the revolutionary movements of the 19th century. Experiments with increasing the size of the hall made it possible to draw a conclusion about the parametric limitations caused by the anthropocentrism of the new European culture. In the last third of the 19th century, a set of requirements for the philharmonic was formed, which were embodied in the halls of Vienna, Leipzig, Amsterdam, New York and Boston. In the 20th-21st centuries, due to the spread of non-academic intonation practices and the appearance of sound-amplifying equipment, a philharmonic hall underwent significant transformations, in particular, a sharp increase in size. At the same time, the desire to preserve the very phenomenon of an acoustic concert caused the appearance of halls of a new configuration, not a traditional "shoe box", but a "vineyard". Therefore, the ways of development of concert halls in our time are characterized by adaptation to market conditions and reflect two diametrically opposite trends: orientation either to enterprises in the artistic sphere or to creative industries.
INSTITUTIONAL ASPECT INNOVATIVE MODERNIZATION OF AGRICULTURAL PRODUCTION
Authors: Oksana Honcharenko , Vasyl Tymoshchuk 
Published: December 2023

The institutional determinants of innovative modernization of agricultural production are substantiated.
It is established that the transformational features domestic agricultural production are monoculture agricultural production, its structural deformation, increased degradation of land and water resources, growing dependence of agricultural producers on imported inputs for the production process, and a reduction in the number of rural workers and the population of rural communities.
It is argued that transformational changes in agro-industrial production should be focused on large-scale modernization changes in the production process in terms of restoring land fertility, improving the quality characteristics of food products, expanding the existing export potential of agricultural products and the share competitive products.
It is established that the threats to the recovery of agricultural production are the narrowing of the domestic consumer market; reduction of the purchasing power of the population with a decrease in its number; reduction and blocking of exports of agricultural products; rising costs of material resources and rising costs of agricultural products and food prices.
It is substantiated that institutional support for the innovative modernization of agro-industrial production should be accompanied by the formation of effective basic and special institutions and institutions that meet the criteria of systematicity when they are included in the hierarchical structure of norms and institutions of innovation.
It is emphasized that the institutional support for innovative modernization should implement the following key tasks: ensuring a favorable investment climate for attracting financial resources to processing enterprises and the formation of local regional structures with low capacity for processing agricultural raw materials; creating conditions for the inclusion of agricultural producers in global value chains.
Institutional interventions should be aimed at stimulating the diffusion and development of product innovations; supporting and shaping organizational structures for vertical and horizontal integration; supporting and shaping organizational frameworks for vertical and horizontal integration; and restructuring forms of state support for agricultural production.
The strategic guidelines for the innovative modernization of agro-industrial production are defined: introduction of motives and incentives for structural changes in agricultural production, intensification of the development of small forms of management, integration of production processes, and use of competitive advantages.