bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal evolution and driving mechanism of slope cultivated land in karst mountainous areas of Southwest China—A case study of Puding County, Guizhou Province
Authors: Yu Limin , Li Yangbing , Luo Guangjie , Ge Guanghui , Zhang Han , Tang Fang , Yu Meng 
Published: October 2023

AbstractSlope‐cultivated land (SCL) is essential for food security and ecological protection in Southwest China's karst mountainous areas (KMA). Constructing a unified conceptual framework to study SCL's spatiotemporal evolution characteristics thoroughly and driving mechanisms can comprehensively reveal the development of regional human–land relations and sustainable land use. Therefore, this article first constructs a conceptual framework for the spatiotemporal evolution of SCL in the KMA of Southwest China and carries out a case study in Puding County, a typical karst mountainous area, based on high‐resolution remote sensing images from 2004 to 2020 and the digital elevation model (DEM), to analyze the spatiotemporal evolution characteristics of SCL in different topographic gradients and introduce the Geodetector further to explore the driving factors of SCL evolution. The results show that the SCL is evolving toward fragmentation, driven by socio‐economic factors. The active policy of the state encourages to abandon steep SCL with poor productivity in the KMA, and the abandonment of SCL in high altitude steep slope areas into woodland and grassland brings remarkable ecological benefits, while the evolution of SCL in low altitude gentle slope areas toward economic fruit forest generates significant obvious ecological‐economic win‐win benefits. The evolution of SCL in southwestern karst mountains has promoted regional ecological restoration and made an important contribution to the greening of the world by reducing land degradation (karstic rocky desertification, KRD). The present research results can provide ideas for the utilization, functional transformation, and ecologically sustainable development of similar mountainous SCL.
Electrophysiological and molecular changes following neuroprotective placental protein administration on tinnitus‐induced rats
Authors: Farhadi Mohammad , Gorji Ali , Mirsalehi Marjan , Poletaev Alexander Borisovich , Asadpour Abdoreza , Mahboudi Fereidoun , Jafarian Maryam , Farrahizadeh Maryam , Akbarnejad Zeinab , Mahmoudian Saeid 
Published: October 2023

AbstractObjectiveDespite 6%–20% of the adult population suffering from tinnitus, there is no standard treatment for it. Placenta extract has been used for various therapeutic purposes, including hearing loss. Here, we evaluate the effect of a novel neuroprotective protein composition (NPPC) extract on electrophysiological and molecular changes in the medial geniculate body (MGB) of tinnitus‐induced rats.MethodsTo evaluate the protein analysis by western blot, the rats were divided into three groups: (1) saline group (intraperitoneal injection of 200 mg/kg saline twice a day for 28 consecutive days, (2) chronic Na‐Sal group received sodium salicylate as in the first group, and (3) chronic treatment group (received salicylate 200 mg/kg twice daily for 2 weeks, followed by 0.4 mg NPPC daily from day 14 to day 28). Single‐unit recordings were performed on a separate group that was treated as in group 4. Gap‐prepulse inhibition of the acoustic startle (GPIAS) and pre‐pulse inhibition (PPI) was performed to confirm tinnitus in all groups at the baseline, 14th and 28th days.ResultsWestern blot analysis showed that the expression of γ‐Aminobutyric acid Aα1 subunit (GABA Aα1), N‐methyl‐d‐aspartate receptor subtype 2B (NR2B or NMDAR2B), α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptors subunit GluR1 (GluR1), and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptors subunit GluR2 (GluR2) decreased after Na‐Sal injection, while NPPC upregulated their expression. MGB units in rats with tinnitus showed decreased spontaneous firing rate, burst per minute, and a spike in a burst. After NPPC administration, neural activity patterns showed a significant positive effect of NPPC on tinnitus.ConclusionNPPC can play an effective role in the treatment of tinnitus in salicylate‐induced rats, and MGB is one of the brain areas involved in these processes.Level of EvidenceNA.
Validating cross‐modal measures for comparative research: Message veracity, novelty, and memorability
Authors: Jensen Jakob D. , Krakow Melinda M. , Christy Katheryn R. , Ratcliff Chelsea L. , Pokharel Manusheela , Lillie Helen 
Published: October 2023

AbstractMarketing researchers are interested in the relative persuasiveness of different message modes, such as narratives and arguments. A desire to explicate and compare underlying mechanisms is central to this research, yet progress is hindered by a dearth of measures that can be used meaningfully across modes. In the current project, we identify and validate three cross‐modal message perceptions—veracity, novelty, and memorability—that can mediate the relationship between different modes and outcomes. Three studies (Study 1: N = 105; Study 2: N = 322; Study 3: N = 248) confirmed the factor structure, discriminant validity, and cross‐modal (narrative vs. argument) value of all three message perceptions. The results of this study provide researchers with three cross‐modal measures to support comparative message effects research.
Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis
Authors: Xiang Xiaocong , Kuang Wei , Yu Chunlei , Li Yuqi , Su Qiang , Tian Yunhong , Li Jingdong 
Published: October 2023

AbstractTestis expression 10 (Tex10) is reported to be associated with tumorigenesis in several types of cancer types, but its role in hepatocellular carcinoma (HCC) metastasis has not been investigated. In this study, the expression of Tex10 in the HCC cell line and tissue microarray was determined by Western blot and immunohistochemistry (IHC), respectively. RNA sequencing‐based transcriptome analysis was performed to identify the Tex10‐mediated biological process. Cell Counting Kit‐8, colony formation, transwell assays, xenograft tumor growth, and lung metastasis experiments in nude mice were applied to assess the effects of Tex10 on cell proliferation, migration, invasion, and metastasis. The underlying mechanisms were further investigated using dual‐luciferase reporter, co‐immunoprecipitation, immunofluorescence, and chromatin immunoprecipitation assays. We found that Tex10 was upregulated in HCC tumor tissues compared to adjacent normal tissues, with its expression correlated with a poor prognosis. Gene ontology function enrichment analysis revealed alterations in several biological processes in response to Tex10 knockdown, especially cell motility and cell migration. Functional studies demonstrated that Tex10 promotes HCC cell proliferation, migration, invasion, and metastasis in vitro and in vivo. Moreover, Tex10 was shown to regulate invasion and epithelial–mesenchymal transition via signal transducer and activator of transcription 3 (STAT3) signaling. Mechanistically, Tex10 was found to interact with STAT3 and promote its transcriptional activity. In addition, we found that Tex10 promotes p300‐mediated STAT3 acetylation, while p300 silencing abolishes Tex10‐enhanced STAT3 transcriptional activity. Together, these findings indicate that Tex10 functions as an oncogene by upregulating STAT3 activity, thus suggesting that Tex10 may serve as a prognostic biomarker and/or therapeutic target for HCC patients.
Progresses in biomarkers for cancer immunotherapy
Authors: Lin Xuwen , Zong Chenyu , Zhang Zhihan , Fang Weiyi , Xu Ping 
Published: October 2023

AbstractCurrently, checkpoint inhibitor‐based immunotherapy has emerged as prevailing treatment modality for diverse cancers. However, immunotherapy as a first‐line therapy has not consistently yielded durable responses. Moreover, the risk of immune‐related adverse events increases with combination regimens. Thus, the development of predictive biomarkers is needed to optimize individuals benefit, minimize risk of toxicities, and guide combination approaches. The greatest focus has been on tumor programmed cell death‐ligand 1 (PD‐L1), microsatellite instability (MSI), and tumor mutational burden (TMB). However, there remains a subject of debate due to thresholds variability and significant heterogeneity. Major unmet challenges in immunotherapy are the discovery and validation of predictive biomarkers. Here, we show the status of tumor PD‐L1, MSI, TMB, and emerging data on novel biomarker strategies with oncogenic signaling and epigenetic regulation. Considering the exploration of peripheral and intestinal immunity has served as noninvasive alternative in predicting immunotherapy, this review also summarizes current data in systemic immunity, encompassing solute PD‐L1 and TMB, circulating tumor DNA and infiltrating lymphocytes, routine emerging inflammatory markers and cytokines, as well as gut microbiota. This review provides up‐to‐date information on the evolving field of currently available biomarkers in predicting immunotherapy. Future exploration of novel biomarkers is warranted.
Recurrent human 16p11.2 microdeletions in type I Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome patients in Chinese Han population
Authors: Su Kaizhen , Liu Han , Ye Xiaoqun , Jin Hangmei , Xie Zhenwei , Yang Chunbo , Zhou Daizhan , Huang Hefeng , Wu Yanting 
Published: October 2023

AbstractBackgroundsMayer‐Rokitansky‐Küster‐Hauser (MRKH) syndrome, a severe congenital malformation of the female genital tract, is a highly heterogeneous disease which has no clear etiology. Previous studies have suggested that copy number variations (CNVs) and single‐gene mutations might contribute to the development of MRKH syndrome. In particular, deletions in 16p11.2, which are suggested to be involved in several congenital diseases, have been reported in Chinese type II MRKH patients and European MRKH patients. However, few CNVs including 16p11.2 microdeletions were identified in Chinese type I MRKH cases although it accounted for the majority of MRKH patients in China. Thus, we conducted a retrospective study to identify whether CNVs at human chromosome 16p11.2 are risk factors of type I MRKH syndrome in the Chinese Han population.MethodsWe recruited 143 patients diagnosed with type I MRKH between 2012 and 2014. Five hundred unrelated Chinese without congenital malformation were enrolled in control group, consisting of 197 from the 1000 Genomes Project and 303 from Fudan University. Quantitative PCR, array comparative genomic hybridization, and sanger sequencing were conducted to screen and verify candidate variant.ResultsOur study identified recurrent 16p11.2 microdeletions of approximately 600 kb in two out of the 143 type I MRKH syndrome patients using high‐density array‐based comparative genomic hybridization (aCGH), while no 16p11.2 deletion was found in the control group. We did not find any mutations in TBX6 gene in our samples.ConclusionsThe results of the study identify 16p11.2 deletion in Chinese MRKH I patients for the first time, as well as support the contention that 16p11.2 microdeletions are associated with MRKH syndrome in both types across populations. It is suggested that 16p11.2 microdeletions should be included in molecular diagnosis and genetic counseling of female reproductive tract disorders.
Occupational groups and lower urinary tract symptoms: A cross‐sectional analysis of women in the Boston Area Community Health Study
Authors: Markland Alayne , Bavendam Tamara , Cain Charles , Neill Epperson C. , Fitzgerald Colleen M. , Yvette LaCoursiere D. , Shoham David A. , Smith Ariana L. , Sutcliffe Siobhan , Rudser Kyle ,   Prevention of Lower Urinary Tract Symptoms Research Consortium
Published: October 2023

AbstractObjectivesThe objective of this study is to inform our hypothesis that the workplace toileting environment may impact lower urinary tract symptoms (LUTS); we examined the prevalence of LUTS across occupational groups in the Boston Area Community Health Survey.MethodsAt baseline, women (n = 3205) reported their occupation and frequency of 15 LUTS. Using the US Department of Labor's Standard Occupational Classification (SOC) system, we categorized women into 11 standard occupational groups. Prevalence ratios (PRs) were calculated by log‐link generalized linear models, adjusting for age, race, education, fluid intake, and parity. Women classified in Office and Administrative Support were used as the reference group given their potential for fewer workplace toileting restrictions.ResultsOf the 3189 women with complete data, 68% of women reported any LUTS, ranging from 57% to 82% across the SOCs. Relative to women in Office and Administrative Support (n = 576), women in Computing, Engineering, and Science (n = 64) were more likely to report any LUTS (PR = 1.2, 95% confidence interval [95% CI]: 1.0–1.4) and urinating again in <2 h (PR = 1.7, 95% CI: 1.4–2.2), and women in Education, Legal, Community Service, Arts, and Media (n = 477), as well as Healthcare Practitioner and Technical Occupations (n = 162), were less likely to report perceived frequent daytime urination (PR = 0.6, 95% CI: 0.5–0.9 and PR = 0.6, 95% CI: 0.4–0.9, respectively).ConclusionsOur cross‐sectional findings suggest that urination frequency varies across understudied occupational groups with various workplace toileting environments. Future studies should examine this relationship prospectively to inform the influence of workplace toileting environments on urination frequency, as well as the development and/or worsening of LUTS.
The pooled analysis evaluates the therapeutic efficacy of desmopressin combined with anticholinergic drugs in the treatment of pediatric nocturnal enuresis
Authors: Tang Gonglin , Liu Hongquan , Wu Gang , Ding Guixin , Chu Yongli , Cui Yuanshan , Wu Jitao 
Published: October 2023

AbstractObjectiveThis pooled analysis aims to demonstrate the clinical efficacy and safety of combined desmopressin and anticholinergic therapy in the treatment of pediatric nocturnal enuresis (NE).MethodsA systematic search was conducted through PubMed, MEDLINE, EMBASE, ResearchGate, and Cochrane Library to identify all randomized controlled trials (RCTs) comparing monotherapy with desmopressin versus combined therapy with desmopressin and anticholinergic agents for the treatment of NE. Data analysis was performed using RevMan version 5.4.1.ResultsThis study included 8 RCTs involving a total of 659 patients. The frequencies of complete response (CR), partial response (PR), and nonresponse (NR) were computed for both short‐term treatment (1 month) and long‐term treatment (3 months). Additionally, alterations in the mean number of NE episodes, adverse events, and relapse were assessed. Our analysis indicates that, in comparison to the monotherapy group, the combination therapy group plays a pivotal role in augmenting the CR odds and diminishing the NR ratios in both short‐term and long‐term treatments (1 month CR ratio [risk ratio (RR): 1.84; 95% confidence interval (CI): 1.22–2.76; p = 0.003, I2 = 72%]; 3 months CR ratio [RR: 1.48; 95% CI: 1.25–1.76; p < 0.00001, I2 = 0%]; 1 month NR ratio [RR: 0.67; 95% CI: 0.55–0.82; p = 0.0001, I2 = 0%]; 3 months CR ratio [RR: 0.37; 95% CI: 0.19–0.73; p = 0.004, I2 = 0%]). Furthermore, in both short‐term and long‐term treatment, the combined therapy group exhibits a greater magnitude of change in the average number of NE episodes compared to patients receiving monotherapy (1 month, mean difference [MD] = −2.97; 95% CI: −4.23 to −1.71, p < 0.0001; 3 months, MD = −4.30; 95% CI: −7.18 to −1.43, p = 0.003). Moreover, the combination therapy group exhibits a significant reduction in the recurrence rate (RR: 0.36; 95% CI: 0.15–0.86; p = 0.02). There is no significant difference in the incidence of adverse events between the two groups (RR: 1.16; 95% CI: 0.58‐2.31; p = 0.67).ConclusionCombining desmopressin with anticholinergic medications is more effective for NE than desmopressin alone, with lower recurrence and minimal adverse effects.
Association between diabetes mellitus and postoperative urinary retention after cerebral angiography
Authors: Chen Xiwen , Yao Shaoli , Peng Cheng , Wu Kongyuan , Lang Hui , Chen Ning 
Published: October 2023

AbstractAimsThe aim of this study is to examine the association between diabetes mellitus and postoperative urinary retention on cerebral angiography (including intravascular interventional therapy).MethodsWe collected data on the demographic characteristics and comorbidities, imaging and routine laboratory data, surgical information, and medications of patients who underwent cerebral angiography. Multivariate logistic regression was used to explore the correlation between diabetes and the incidence of postoperative urinary retention.ResultsA total of 932 patients were included, with a mean age of 59.7 years (74.1% men). Postoperative urinary retention occurred in 40.8% of the diabetes mellitus group and 30.3% of the group without diabetes. Compared with the group without diabetes, those with diabetes were more likely to experience postoperative urinary retention. Patients with higher glycosylated hemoglobin A1c levels had a higher risk of developing postoperative urinary retention.ConclusionsDiabetes was independently linked to postoperative urinary retention following cerebral angiography and patients with glycosylated hemoglobin A1c levels > 6% were more likely to experience postoperative urinary retention. Therefore, clinically regulating blood glucose levels may help to reduce the likelihood of postoperative urinary retention after cerebral angiography.
How does entrepreneur core self‐evaluation affect entrepreneurial orientation in social enterprises? Evidence from China
Authors: Peng Xiaobao , Chen Yuhui , Ge Rile , Hou Sihan , Li Mengying 
Published: October 2023

AbstractWith the global trend of sustainable development, traditional nonprofit organizations are facing the challenge of economic value creation. Entrepreneurship offers a possibility for nonprofit organizations to survive with innovative business methods. Entrepreneurial orientation (EO) reflects the degree of innovativeness, proactiveness, and risk‐taking in terms of organizational entrepreneurial behavior. Research on the mechanisms of EO formation in a social context is still in the exploratory stage. While a large number of studies have explored dimensional modifications to EO, it has yet to consider how EO in a social context is affected at the individual level. To address this gap, we explain the potential impact of social entrepreneurs’ core self‐evaluation (CSE) on EO from social cognitive theory using a sample of Chinese social enterprises. The findings suggest that CSE has a significant positive effect on EO. We also distinguish the partially mediating role played by the two approaches and avoidance motives. The findings also suggest that the high socioeconomic status of social entrepreneurs strengthens the relationship between CSE and EO, as well as the relationship between CSE and both motives. Our findings provide valuable insights into the decision‐making behavior of social enterprises for sustainable development.
Standardization of dual‐energy x‐ray visceral adipose tissue measures for comparison across clinical imaging systems
Authors: Bennett Jonathan P. , Fan Bo , Liu En , Kazemi Leila , Wu Xian‐Ping , Zhou Hou‐De , Lu Ying , Shepherd John A. 
Published: October 2023

AbstractObjectiveExcess visceral adipose tissue (VAT) is a major risk factor for metabolic syndrome (MetS) and clinical guidelines have been proposed to define VAT levels associated with increased risk. The aim was to standardize VAT measures between two dual‐energy x‐ray absorptiometry (DXA) manufacturers who provide different VAT estimates to support standardization of measures across imaging modalities.MethodsScans from 114 individuals (ages 18–81 years) on GE HealthCare (GEHC) and Hologic DXA systems were compared via Deming regression to standardize VAT between the two systems, validated in a separate sample (n = 15), with κ statistics to assess agreement of VAT measurements for classifying patients into risk categories.ResultsThe GEHC and Hologic VAT measures were highly correlated and validated in the separate data set (r2 = 0.97). VAT area measures substantially agreed for metabolic risk classification (weighted κ = 0.76) with no significant differences in the population mean values.ConclusionsVAT measures can be estimated from GEHC and Hologic scans that classify individuals in a substantially similar way into metabolic risk categories, and systematic bias between the measures can be removed using simple regression equations. These findings allow for DXA VAT measures to be used in complement to other imaging modalities, regardless of whether scans used GEHC or Hologic systems.
A material model for thick, rate‐dependent adhesives with delocalized softening
Authors: Schumacher Aaron , Matzenmiller Anton 
Published: October 2023

AbstractThis contribution is dedicated to the development and implementation of a material model to describe the deformation behaviour of assembly adhesives. These assembly adhesives are usually used with thicknesses of several millimetres up to centimetres in order to compensate for large relative displacements of joining parts. These large displacements can be resisted by assembly adhesives, since they have a low shear modulus and thus a high strain until failure above their glass transition temperature. As a basis, the isothermal and isotropic hyperelasticity theory is used to describe the elastic deformation behaviour up to the postcritical range by using an isochoric–volumetric decomposition of the deformation gradient. The Arruda–Boyce and Ogden models are employed here for the isochoric‐elastic and volumetric‐elastic description. The modelling of the rate‐dependence concerning shear and bulk viscosity succeeds by extending the hyperelasticity theory to the theory of finite viscoelasticity with the generalized Maxwell model in each case. In order to model the postcritical deformation behaviour, an isotropic damage model is developed based on the energy limiting method and used to define an isochoric and a volumetric damage variable, so that the mapping of softening due to change of shape, as well as cavitation, succeeds. Furthermore, the damage variables are delocalized to prevent pathological mesh dependence by using the integral regularization method. Finally, the material parameters are determined and validated by means of measurement data due to tests at the assembly adhesive Betaforce 2850L. The results demonstrate a high prediction quality.