bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain in very preterm infants—prevalence, causes, assessment, and treatment. A nationwide cohort study
Authors: Graham Hillary , Razaz Neda , Håkansson Stellan , Blomqvist Ylva Thernström , Johansson Kari , Persson Martina , Nyholm Annika , Norman Mikael 
Published: January 2025

Abstract
Studies on pain in preterm infants have usually been confined to observations of painful procedures, and information from extremely preterm infants is limited. Using registry data from a Swedish nationwide cohort, this study explored the epidemiology of pain in very preterm infants, its causes, assessments, and treatment strategies. We included liveborn infants <32 weeks' gestational age (GA) discharged between January 2020 and June 2024. Proportions of infants exposed to potentially painful procedures, experiencing pain, assessed with pain scales, and receiving pharmacological treatment were calculated by each postnatal day. Among 3686 infants (mean birthweight 1176 g, GA 28.2 weeks), 11.6% had a painful condition and 84.1% were exposed to at least 1 potentially painful procedure. In total, 74.6% experienced pain, corresponding to 28,137/185,008 (15.2%) days of neonatal care. For every 2-week increase in GA, significantly lower proportions of infants experienced pain. In infants <28 weeks of GA, proportions with reported pain were approximately half the rate of painful procedures, while in infants born at 28 to 31 weeks, reported pain closely matched exposure to painful procedures. Pain scales were used in 75.0% of the infants. Pharmacological pain treatment was administered to 81.7% of infants, primarily topically or orally. Among infants with pain, proportions treated intravenously were larger at higher GAs. Despite effective analgesia/anesthesia, many very preterm infants experience pain. Visualizing pain epidemiology, procedures, conditions, and treatment by postnatal and gestational age may guide clinical management and generate research hypotheses to reduce short- and long-term adverse effects.
Improving Timely Evaluation of Newborns at Risk for Hemolytic Disease From a Positive Maternal Antibody
Authors: Samaras Athena T. , Sweeney Alison E. , Lewis Emilee C. , Thompson Julie A. , Waldrop Julee 
Published: January 2025

Background:
Hemolytic disease of the newborn (HDN) is a rare condition with the potential for high morbidity.

Local Problem:
Practice at a large maternity care center did not align with the American Academy of Pediatrics (AAP) revised hyperbilirubinemia guidelines.

Methods:
A pre/post-implementation design with Plan-Do-Study-Act cycles was used.

Interventions:
A clinical pathway was implemented to improve timely evaluation of newborns at risk for HDN due to a positive maternal antibody using cord blood.

Results:
Cord blood testing increased among the subset of newborns who did not meet collection criteria prior to the practice change (pre: 0% n = 7, post: 39% n = 23). Missed opportunities to test cord blood occurred less frequently post (35 versus 26 days between missed opportunities). Feasibility data identified the need for educational and clinical tools.

Conclusions:
A clinical pathway and tailored tools support the AAP recommendation. Electronic health record supports could bolster future efforts.
Survival Disparity and the Unique Genomic and Microbiome Profiles of Colon Cancer in Appalachian Kentucky
Authors: McDonald Hannah G , Reagan Anna M , Faisal Abu Saleh Mosa , Goettl Ryan , Wang Chi , Hoyd Rebecca , Spakowicz Daniel , Evers B Mark , Kim Joseph , Bhakta Avinash S 
Published: January 2025

Background:
Colon cancer is a leading cause of mortality in Appalachian Kentucky. Studies suggest that the microbiome may influence cancer outcomes. We investigate differential gene expression, the tumor microbiome, and the association between the two as potential drivers of disparities in colon cancer outcomes.

Study Design:
This study analyzed patients diagnosed with colon adenocarcinoma between 2010-2023. Demographic data were extracted from Kentucky Cancer Registry. Somatic mutations and significantly mutated genes were identified using Fischer’s exact T-test. RNASeq data was processed for gene expression analysis and Holm-Bonferroni method was used to adjust p-values for multiple comparisons. The STAR aligner, (exotic)v2.1 pipeline, and KrakenUniq database were used to classify microbes in human samples. The R package (exotic) was then used to decontaminate the results.

Results:
The final cohort included 2276 patients, 321 of which had available somatic mutation sequencing data. Demographic differences between Appalachian and non-Appalachian patients included marital status (P = 0.0005), race (P < 0.0001), insurance status, (P = 0.0005), BMI (P = 0.001), type 2 diabetes (P < 0.0001) and Charlson Comorbidity Index (CCI; P = 0.03). There was no difference in gene mutation frequency. There was differential expression of 228 genes. Differential abundance analysis revealed differences in 381 bacterial species. Importantly, 3 microbiota significantly correlated with survival disparities between Appalachian and non-Appalachian patients: C. cadaveris (adjusted P = 0.009), L. salivarius (adjusted P = 0.048), and S. wadsworthensis (adjusted P = 0.009).

Conclusion:
This is the first report of the distinct tumor microbiome in Appalachian Kentucky and its impact on survival. Further studies are needed to better characterize the unique tumor and gut microbiome of Appalachian patients with colon cancer.
The Batch-Resourcing Angiogenesis Tool (BRAT) to enable high-content microscopy screening of microvascular networks
Authors: Krek Harriet , Murphy Ashley R. , McKinnon Ryan , Franco Rose Ann , Allenby Mark C. 
Published: January 2025

AbstractVessel forming assays are a valuablein vitrotechnology to evaluate the vasculogenic and angiogenic potential of different cell types, matrix proteins, and soluble factors. Recent advances in high-content microscopy allow for vascular morphogenesis assays to be captured in real-time and in high-throughput screening purposes. Unfortunately, existing microvascular network quantification algorithms are either inaccurate, not user-friendly, or manually analyse one image at a time, unfavourable to high-content screening applications. This manuscript introduces BRAT, the Batch-Resourcing Angiogenesis Tool, a computer algorithm with an open-source graphic user interface to efficiently segment, skeletonize, and analyse large batches of vascular network images with high accuracy. Benchmarked across diverse clinical and cultured microvascular network images, BRAT is the most sensitive vascular network image analysis tool (94.5%) and exhibits leading accuracy (93.3%). BRAT’s multi-threaded processing automatically analysed 886 microscopy images at a speed of 0.17 seconds/image (2:29 minutes) on a performance computer or 2.31 seconds/image (34:04) on a typical laptop. This is 10-to-100 fold more time-efficient than existing tools, which require 12 to 16 seconds of direct user input per image. BRAT is broadly useful to analyse vessel networks of different endothelial cell types cultured on 2D substrates and within 3D biomaterials. BRAT represents a powerful approach for the accurate and high-content screening of vessel forming assays for disease models, regenerative medicines, and therapeutic testing.
Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation
Authors: Bridgers Joseph B. , Carlström Andreas , Sherpa Dawafuti , Couvillion Mary T. , Rovšnik Urška , Gao Jingjing , Wan Bowen , Shao Sichen , Ott Martin , Churchman L. Stirling 
Published: January 2025

AbstractMitochondrial gene expression is essential for oxidative phosphorylation. Mitochondrial-encoded mRNAs are translated by dedicated mitochondrial ribosomes (mitoribosomes), whose regulation remains elusive. In the baker’s yeastSaccharomyces cerevisiae, nuclear-encoded mitochondrial translational activators (TAs) facilitate transcript-specific translation by a yet unknown mechanism. Here, we investigated the function of TAs containing RNA-binding pentatricopeptide repeats (PPRs) using selective mitoribosome profiling and cryo-EM structural analysis. These analyses revealed that TAs exhibit strong selectivity for mitoribosomes initiating on their target transcripts. Moreover, TA-mitoribosome footprints indicated that TAs recruit mitoribosomes proximal to the start codon. Two cryo-EM structures of mRNA-TA complexes bound to post-initiation/pre-elongation-stalled mitoribosomes revealed the general mechanism of TA action. Specifically, the TAs bind to structural elements in the 5’ UTR of the client mRNA as well as to the mRNA channel exit to align the mRNA in the small subunit during initiation. Our findings provide a mechanistic basis for understanding how mitochondria achieve transcript-specific translation initiation without relying on general sequence elements to position mitoribosomes at start codons.
Striatal cell-type specific stability and reorganization underlying agency and habit
Authors: Malvaez Melissa , Liang Alvina , Hall Baila S. , Giovanniello Jacqueline R. , Paredes Natalie , Gonzalez Julia Y. , Blair Garrett J. , Sias Ana C. , Murphy Michael D. , Guo Wanyi , Wang Alicia , Singh Malika , Griffin Nicholas K. , Bridges Samuel P. , Wiener Anna , Pimenta Jenna S. , Holley Sandra M. , Cepeda Carlos , Levine Michael S. , Blair H. Tad , Wikenheiser Andrew M. , Wassum Kate M. 
Published: January 2025

ABSTRACTAdaptive decision making requires agency, knowledge that actions produce particular outcomes. For well- practiced routines, agency is relinquished in favor of habit. Here, we asked how dorsomedial striatum D1+and D2/A2A+neurons contribute to agency and habit. We imaged calcium activity of these neurons as mice learned to lever press with agency and formed habits with overtraining. Whereas many D1+neurons stably encoded actions throughout learning and developed encoding of reward outcomes, A2A+neurons reorganized their encoding of actions from initial action-outcome learning to habit formation. Chemogenetic manipulations indicated that both D1+and A2A+neurons support action-outcome learning, but only D1+neurons enable the use of such agency for adaptive, goal-directed decision making. These data reveal coordinated dorsomedial striatum D1+and A2A+function for the development of agency, cell-type specific stability and reorganization underlying agency and habit, and important insights into the neuronal circuits of how we learn and decide.
How workers construct a sense of positive occupational identity in a contested emerging profession: the case of career coaches
Authors: Felix Bruno , Vieira Ana Patricia Alves 
Published: January 2025

PurposeUsing the empirical context of the coaching profession, this study explores how workers in a partially contested and emerging occupation construct a sense of positive occupational identity.Design/methodology/approachWe adopted a grounded theory method, drawing on interviews with 43 Brazilian career coaches, supplemented by documentary analysis of archival materials related to the profession and non-participant observations conducted during training sessions for these professionals.FindingsParticipants report the ambiguity of their occupational roles as career coaches, with expectations from different groups sometimes aligning and sometimes conflicting. Instead of striving for a homogeneous expectation of how career coaches should be, they suggest finding a sufficient balance between their perceived selves and diverse expectations. This attainable authenticity is reflected in participants' reliance on validation from supportive social groups rather than those who disapprove of career coaching as a vocation. We contend that two combined factors were essential for these professionals in a simultaneously contested and emerging occupation to construct a positive occupational identity. The first involves recognizing that they cannot be entirely authentic in their profession but can be sufficiently authentic. The second is that they should not rely on universal societal approval but instead leverage approval from certain societal groups, accepting that not everyone will approve of them.Originality/valueThis paper represents an original effort to explore how career coaches endeavor to build a positive occupational identity, considering the context of a simultaneously contested and emerging occupation. The simultaneous consideration of these factors, through the specific case of career coaches, was innovative for the literature.
Effects of justice perception on contractor value co-creation behavior in infrastructure megaprojects: the mediating role of psychological ownership
Authors: Tian Bo , Fu Jiaxin , Xu Yongshun , Li Jinjin 
Published: January 2025

PurposeAs the complexity and uncertainty of infrastructural megaprojects challenge traditional management models, there is an increasing focus on value co-creation as an organizational strategy to streamline management. However, the role of value co-creation behavior in facilitating the value realization process remains underexplored. This study examines how justice perception (distributive, procedural and interactional justice) improves contractor value co-creation behavior, focusing on the mediating role of psychological ownership.Design/methodology/approachTen hypotheses in the proposed research model were tested through partial least squares structural equation modeling using 199 valid questionnaires from China.FindingsThe results show that contractor value co-creation behavior is directly and positively influenced by procedural, distributive and interactional justice and indirectly influenced by them through the underlying psychological mechanism of psychological ownership.Originality/valueThe findings fill a knowledge gap by examining the effect of justice perception on contractor value co-creation behavior based on social exchange theory. Discovering justice perception will contribute to contractor value co-creation behavior, and psychological ownership mediates this relationship.
Investigating students’ awareness of online privacy and cybersecurity: an empirical study with effective cybersecurity training framework
Authors: Azad Rahat Uddin , Tasmim Sabiha , Atikuzzaman Md. 
Published: January 2025

Purpose
The main purpose of this study is to assess the level of cybersecurity and social media privacy awareness among college students in Bangladesh and propose a scalable cybersecurity training framework to promote safe online practices.

Design/methodology/approach
This study used a structured, printed questionnaire survey to collect data from the students of five renowned colleges from the southern part of Bangladesh. Stratified sampling technique was followed and a total of 353 data were collected. Collected data were analyzed using SPSS and Python programming languages.

Findings
The findings uncovered that most of the students possessed limited knowledge regarding fundamental cybersecurity concepts, though they were using different social media platforms and posting personal information frequently. The study found a significant positive relationship between students’ sharing of personal information on social media and becoming a victim of cybersecurity attacks. Contrarily, becoming a victim of a cybersecurity attack was negatively correlated with their ability to respond in case of cyberattacks. However, most of the students were interested in acquiring knowledge of cybersecurity. Based on these findings, the study proposed a game-based cybersecurity training framework for students named “CyberSAFE”.

Originality/value
Though several studies have proposed different cybersecurity frameworks in different contexts, this study, to the best of the authors’ knowledge, is the first attempt to explore college students’ cybersecurity knowledge and propose a game-based framework in a developing country setting.
Mapping employability: a decade of trends and insights from higher education through bibliometric analysis (2014–2024)
Authors: Sulistiawan Jovi 
Published: January 2025

Purpose
This study aims to investigate the evolution of employability research within higher education from 2014 to 2024, using the career capital framework to provide a multifaceted perspective on employability.

Design/methodology/approach
The data set, comprising 468 documents from 1,170 authors, was analyzed using VOSviewer and the Bibliometric package in R, which enabled the visualization of bibliometric networks and the identification of significant research trends and influential publications.

Findings
Key findings emphasize the critical role of higher education in developing employability and the impact of various forms of graduate capital. The study reveals a shift from a narrow focus on job attainment to a broader perspective that includes long-term career sustainability and adaptability.

Research limitations/implications
Future research should explore contextual factors and develop holistic employability models. Interdisciplinary approaches and policy-informing studies are also recommended to enhance graduate employability in a dynamic global labor market. This research contributes to a deeper understanding of employability, supporting the development of effective strategies for preparing individuals for successful and adaptable careers.

Originality/value
This study integrates the component of graduate capital with employability, providing a more sophisticated comprehension of employability that surpasses conventional measurements. Having this viewpoint is crucial for higher education institutions to provide graduates with the necessary skills for long-term professional success and flexibility in a continuously changing job market. Furthermore, it provides valuable insights for the creation of educational programs and career services that can effectively equip students with the necessary skills and knowledge to navigate the intricacies of the contemporary labor market.
Predicting healthy lifestyle behavior among married people: integrating theory of planned behavior, health belief model, body image dissatisfaction and habit
Authors: Md Nor Siti Maryam , Abdullah Haslinda , Zaremohzzabieh Zeinab , Osman Syuhaily , Wan Jaafar Wan Munira 
Published: January 2025

PurposeThis study aimed to investigate the determinants of healthy lifestyle behavior in married people. It also sought to propose an integrative model that incorporates variables from two theoretical models, namely, the theory of planned behavior (TPB) and the health belief model (HBM), as well as two additional variables, namely habit and body image dissatisfaction.Design/methodology/approachQuestionnaires were used to gather data, and structural equation modeling (SEM) was applied for statistical analysis. Data were collected from 404 respondents using several assessment tools, including the Health Belief Model Scale, the Theory of Planned Behavior Scale, the Healthy Lifestyle Belief Scale, the Body Area Scale, and the Creature of Habit Scale.FindingsThe findings showed that perceived severity is the predictor of a healthy lifestyle attitude, followed by subjective norm, perceived behavior control, and healthy lifestyle attitude as the primary attendants of intention. Meanwhile, it was found that a healthy lifestyle attitude is a significant mediator in the perceived severity and healthy lifestyle intention relationship. The suggested model outperforms the original TPB and HBM models in predictive ability, proving its utility and efficacy in describing healthy lifestyle behavior.Originality/valueAdding constructs in the TPB and HBM models contributed considerably to improving the understanding of healthy lifestyle behavior among married people. Governments and policymakers might utilize the findings to design and execute a new program or a sustained healthy lifestyle for married people.
Investigation of electrical conductivity and sensor properties of MWCNT reinforced nanocomposite textile surfaces
Authors: Inan Rusen , Usta Ismail , Sahin Yesim Muge 
Published: January 2025

PurposeThe aim of the study is primarily to ensure the electrical conductivity of the nanocomposite textile surface that is produced. Subsequently, the sensor properties were determined by monitoring the resistance changes under tensile forces.Design/methodology/approachThermoplastic polyurethane solution was prepared by adding MWCNT and SDS for the production of a nanocomposite textile surface by the electrospinning method. In the present study, it was aimed to improve the conductivity and sensor properties by increasing the surface area via nanotechnological production methods depending on the MWCNT and SDS ratios.FindingsIt was determined that the vertical and horizontal samples taken from the produced nanocomposite surfaces had electrical properties. In the present study, the relation between the SDS and MWCNT incorporation has been proven not only with the viscosity but also with the conductivity values of the solution. On the other hand, enhanced conductivity is obtained for the SDS-incoorporated nanocomposites for which homogeneous distribution is maintained. The findings of the study indicate that there were resistance changes for the produced nanocomposite surfaces under tension forces, and thus sensor properties were obtained.Originality/valueIt has been observed that studies on textile-based sensors have increased in recent years. In these studies, conductive materials are adapted to textile structures by coating and impregnation methods. In the present study, nanocomposite surfaces were obtained by the electrospinning method with the incoorporation of conductive MWCNT and SDS into a thermoplastic polyurethane solution. Owing to the homogeneous distribution of the conductive particles into the composite system, the conductivity of the nanomats was remarkably enhanced. For the obtained nanocomposite mats, resistance change under extension stress is maintained, and thus they can be utilized as strain sensors.
Impact of institutional change programs on digital and sustainable public sector governance
Authors: Latorcai Csaba János , Strausz Péter , Csedő Zoltán 
Published: January 2025

PurposeInstitutional change (IC) programs in the public sector are often driven by sustainability and digitalisation as contextual factors, contributing to the development of digital and sustainable governance (DSG) systems. This study aims to explore the longitudinal impact of ICs on DSG advancements.Design/methodology/approachWe collected and analysed data of 200 public sector organisations in two European countries and conducted a longitudinal analysis, focusing on the impact of European Union-funded IC programs.FindingsResults show that steps towards digital governance (DG) are demonstrably linked to environmental efforts, and EU-funded IC programs could have a long-term positive impact on digital and environmentally sustainable governance in Europe. Findings, however, highlight the unbalanced nature of sustainability governance, as environmental and policy-related conditions and activities seem to be overemphasised.Practical implicationsEnvironmental policy seems to be established, but future DG initiatives should consider more environmental polity conditions and activities (e.g. dedicated departments), as well as economic and social sustainability to ensure well-balanced governance systems.Originality/valueTo the best of our knowledge, this is the first study that explores empirically how prior IC programs affect future DSG in the public sector.