bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on Screening Core Biomarkers of Noise and Drug-Induced Hearing Loss Based on Transcriptomics
Authors: Qiu Xin , Jiang Qing-Qing , Guo Wei-Wei , Yu Ning , Yang Shi-ming 
Published: December 2023

Abstract
Background Noise and drug-induced hearing loss (HL) is becoming more and more serious, but the integration and analysis based on transcriptomics and proteomics are lacking. On the one hand, this study aims to integrate existing public transcriptomic data on noise and gentamicin-induced HL. On the other hand, the study aims to establish the gentamicin and noise-induced HL model of guinea pigs, then to perform the transcriptomic and proteomic analyses. Through comprehensive analysis of the above data, we aim to screen, predict, and preliminarily verify biomarkers closely related to HL.
Material and Methods We screened the Gene Expression Omnibus database to obtain transcriptome data expression profiles of HL caused by noise and gentamicin, then constructed the guinea pig HL model and perform the transcriptomic and proteomic analyses. Differential expression and enrichment analysis were performed on public and self-sequenced data, and common differentially expressed genes (DEGs) and signaling pathways were obtained. Finally, we used proteomic data to screen for common differential proteins and validate common differential expression genes for HL.
Results By integrating the public data set with self-constructed model data set, we eventually obtained two core biomarkers of HL, which were RSAD2 and matrix metalloproteinase-3 (MMP3). Their main function is to regulate the development of sense organ in the inner ear and they are mainly involved in mitogen-activated protein kinase and phosphoinositol-3 kinase/protein kinase B signaling pathways. Finally, by integrating the proteomic data of the self-constructed model, we also found differential expression of MMP3 protein. This also preliminarily and partially verified the above-mentioned core biomarkers.
Conclusion and Significance In this study, public database and transcriptomic data of self-constructed model were integrated, and we screened out two core genes and various signal pathways of HL through differential analysis, enrichment analysis, and other analysis methods. Then, we preliminarily validated the MMP3 by proteomic analysis of self-constructed model. This study pointed out the direction for further laboratory verification of key biomarkers of HL, which is of great significance for revealing the core pathogenic mechanism of HL.
Fijación percutánea sin injerto vs fijación abierta con injerto en retardo de consolidación estable de escafoides: Analisis retrospectivo
Authors: Miró José Ignacio , Vaquero Alfonso García , Lupotti Carlos José , Rodríguez Gustavo Luis Gómez 
Published: December 2023

Resumen
Introduccion Actualmente hay controversia sobre el manejo quirúrgico más adecuado del retardo de consolidación de escafoides sintomático. Hay pocos estudios comparativos entre las diferentes alternativas de tratamiento. El objetivo del estudio es comparar los resultados obtenidos entre la osteosíntesis percutánea sin injerto óseo asociado, y la reducción abierta y fijación interna con autoinjerto esponjoso para el retardo de consolidación de escafoides estable.
Material y Metodos Se realizó un estudio retrospectivo con 24 pacientes: 13 pacientes intervenidos mediante osteosíntesis percutánea sin injerto y 11 pacientes intervenidos mediante reducción abierta y fijación interna asociando injerto esponjoso. La variable principal de estudio fue el tiempo medio de consolidación en semanas. Se midieron variables radiológicas secundarias en el pre y posoperatorio: ángulo escafolunar, distancia escafolunar, ángulo lunogrande, ángulo radiolunar, longitud escafoides, ángulo intraescafoideo lateral, y variables funcionales secundarias a las 6 , 12 y 24 semanas: rango de movilidad en flexión, extensión, desviación radial y cubital, dolor en escala VAS, valoración Quick Dash y PRWE, número medio de sesiones de fisioterapia y tiempo medio de reincorporación a actividad laboral. Se empleó el test de U de Mann-Whitney para variables cuantitativas y el test de Ji-Cuadrado para las cualitativas, estableciendo un nivel de significación en p < 0,05.
Resultados El tiempo medio en semanas hasta la cirugía fue de 10 semanas en el grupo sin injerto y 23 semanas en el grupo con injerto. El tiempo medio de consolidación en semanas en el grupo sin injerto fue de 10 sem (R 8-12 sem) y en el grupo con injerto de 12 sem (R 8-20 sem) (p = 0,002). Se obtuvo un 100% de consolidación en todos los casos. Se obtuvieron diferencias a favor del grupo sin injerto para los siguientes parámetros : EVA a los 3 meses (5 vs 7 , p = 0,002), 6 meses (3 vs 6 p = 0,000) y al año (1 vs 2 p = 0,001); DASH 1 año (9 vs 24 p = 0,000); PRWE 1 año (6 vs 10 p = 0,011), flexión media 6 meses (65° vs 45° p = 0,010); extensión media 6 meses (70° vs 46° p = 0,009); desviación cubital 6 meses (25° vs 15° p = 0,047). Se obtuvieron diferencias a favor del grupo con injerto en el parámetro desviación radial 6 meses (15° vs 12° p = 0,038). El tiempo medio de incorporación al trabajo fue de 8 semanas de media en los dos grupos.
Conclusion Para tratamiento quirúrgico del retardo de consolidación en fracturas de escafoides sin criterios de inestabilidad, la osteosíntesis percutánea sin injerto óseo asociado podría ser un tratamiento superior a la reducción abierta y fijación interna con autoinjerto esponjoso en cuanto a tiempo de consolidación radiológica y recuperación funcional.
Revisión de prótesis trapeciometacarpiana de doble movilidad en pacientes con rizartrosis: Nuestra experiencia en un estudio de 66 casos. Bajo riesgo de luxación y escasas complicaciones
Authors: Suárez-López del Amo Álvaro , Olhas-Ortiz Laura , Gil-Melgosa Lara , Martínez-Burgos Isabel , Pajares-Cabanillas Samuel 
Published: December 2023

Resumen
Introducción Las prótesis trapeciometacarpianas son implantadas desde hace más de 50 años. Entre sus complicaciones, destacan la posibilidad de osteolisis, aflojamiento o luxación. Con el fin de disminuir el riesgo de luxación, se desarrollaron las prótesis trapeciometacarpianas de doble movilidad.
Material y Métodos Se analizaron 66 casos de prótesis trapeciometacarpiana de doble movilidad intervenidos entre 2019 y 2022, y se evaluaron los resultados de funcionalidad, movilidad, dolor y aparición de complicaciones.
Resultados El 76.7% fueron mujeres y la edad media de 62.4 años. El dolor medido en escala EVA disminuyó de 8.1 preoperatorio a 1.5 postoperatorio. En el 92.6% de los pacientes, el índice de Kapandji al mes de la cirugía se encontraba entre 9 y 10. Además, el QuickDASH disminuyó de 46.2 a 9.8. Encontramos en el primer mes tras la cirugía dos casos de aflojamiento de cotilo y una fractura de trapecio. Desde el primer mes hasta cumplir el año, tuvimos un caso de aflojamiento de vástago. Estas complicaciones requirieron tratamiento quirúrgico de revisión. No observamos ningún caso de luxación.
Conclusiones La prótesis trapeciometacarpiana de doble movilidad es una opción quirúrgica con buen resultado funcional, de movilidad y supervivencia para pacientes con rizartrosis candidatos a cirugía.
Evolución radiológica de coalición entre escafoides y trapecio a lo largo de la ósificación del carpo
Authors: Olmedo Martín Estefanía , López Salinas José Tomás , Morales Sánchez-Migallón Carlos 
Published: December 2023

ResumenLas coaliciones carpianas son la unión de dos o más huesos del carpo. Presentan una baja incidencia, siendo el diagnóstico incidental. Nuestro objetivo es describir la evolución radiográfica de esta malformación durante la osificación a propósito de un caso. Varón de 15 años, con fracturas repetidas de escafoides derecho, al que se diagnostica de coalición entre escafoides y trapecio no ósea bilateral tras estudio complementario. El paciente contaba previamente con controles radiográficos de la muñeca izquierda desde la infancia hasta la maduración esquelética. Todos los huesos del carpo se osifican a partir de un núcleo primario de osificación, apareciendo secuencialmente. Comparando los controles radiográficos con las series óseas de referencia, se acentúan las diferencias a partir de los 9 años, al finalizar la osificación. Las coaliciones carpianas son poco frecuentes y pasan desapercibidas hasta la maduración esquelética del carpo. Presentan una mayor susceptibilidad al estrés mecánico, y mayor riesgo sufrir fracturas tras traumatismos.
Dosing, Monitoring, Blood Product Utilization, and Thromboembolic Complications of Four-Factor Prothrombin Complex Concentrate as Part of an Institutional Protocol in Pediatric Cardiac Surgery: A Retrospective Cohort Study
Authors: Kiskaddon Amy L. , Goldenberg Neil A. , Fierstein Jamie L. , Miller Alexandra , Quintessenza James A. , Kartha Vyas M. 
Published: December 2023

AbstractPediatric cardiac surgery patients are predisposed to blood loss. Blood product administration can lead to complications. Prothrombin complex concentrates (PCCs) offer potential advantages of factor composition, small volume, decreased immunogenicity/infectious risks, and accessibility. The objective of this study was to describe dosing, monitoring, blood product utilization, and thromboembolic complications of administering four-factor PCC (4F-PCC) in pediatric cardiac surgery. We performed a retrospective review of patients aged <18 years undergoing cardiac surgery from June 2020 to May 2022 (inclusive) who received 4F-PCC. Outcomes of interest included 4F-PCC dosing (units/kg) and number of doses administered, chest tube output, blood product administration, donor exposure, length of stay, and thromboembolic events. Eighty-six patients met eligibility criteria. The median (range) age and weight were 0.37 (0.01–16.3) years and 5.3 (1.6–98) kg, respectively. Median (range) total 4F-PCC dose per patient was 25 (9.2–50) units/kg, with 6 patients (7%) receiving a total of two doses. Median (range) 24-hour postoperative packed red blood cells, platelet, plasma, and cryoprecipitate administration volumes were 0 (0–2.57) mL/kg/24 h, 0 (0–1.09), 0 (0–2.64), and 0 (0–0.28 mL/kg/24 h), respectively. Median (range) length of stay and 24-hour postoperative chest tube output were 10 (6–26) days and 1.1 (0.1–4.2) mL/kg/h, respectively. Two (2%) patients experienced a thromboembolic event within 30 days of 4F-PCC administration. These retrospective findings suggest no worsening of hemostatic parameters, a mild median improvement in fibrinogen, low blood product utilization, and low thromboembolism rates following 4F-PCC use in pediatric cardiac surgery.
Deep-Plane Rhytidectomy: Pearls in Maximizing Outcomes while Minimizing Recovery
Authors: Gordon Neil A. , Sawan Tareq G. 
Published: December 2023

AbstractThe deep-plane rhytidectomy was first described in 1990 and has gained traction in the past decade as supported by anatomy, embryology, and clinical evidence. Consumer dissatisfaction in facial rejuvenation procedures often occurs because procedures are too conservative and are undone. From the consumer's perspective, an outcome is a combination of the esthetic result, predictability, and the length of the recovery process. The length of the recovery process is often the limiting issue affecting the consumer's willingness to proceed with the procedure. As one of the early pioneers in deep-plane rhytidectomy, the lead author will define contemporary advances in deep-plane techniques such as dissection entry point, flap design, and flap fixation concepts that allow an aggressive approach to treating both the superficial soft tissue envelope and deeper facial aging structures. These technique modifications and insights will provide the surgeon with an understanding of how to achieve significant, natural, long-lasting results with predictable short recovery periods—maximizing outcomes and minimizing postoperative processes.
Linking local collaborative governance and public service delivery: mediating role of institutional capacity building
Authors: Zia ud din Muhammad , Yuan yuan Xu , Khan Naqib Ullah , Han Heesup 
Published: December 2023

AbstractCollaborative governance has received attention among scholars and practitioners for resolving governance issues across the globe. The government of Pakistan emphasizes local collaborative governance practices for resolving complex local problems through efficient public service delivery. This research is planned to examine the impact of local collaborative governance on public service delivery, institutional capacity building and how local collaborative governance influences public service delivery through the mediating mechanism of institutional capacity building. Using collaborative governance theory and collecting data from multisector organizations in the context of Pakistan, the results of this study revealed that local collaborative governance is significantly related to the dimensions of public service delivery and institutional capacity building. This research findings revealed that local collaborative governance engenders public service delivery through the dimensions of institutional capacity building including service capacity, evaluative capacity, and M&O capacity.
The poverty alleviation effect of transfer payments: evidence from China
Authors: Miao Yan , Li Zheng 
Published: December 2023

AbstractTransfer payments play a crucial role in combating poverty in countries. However, the effectiveness of transfer payments in alleviating poverty remains controversial due to variations in environmental factors, economic development, and cultural contexts across different nations. In this study, we employ counterfactual causal inference to examine the influence of government transfer payments on poverty. By utilizing data from China, we present new evidence that sheds light on related issues. Our findings reveal that transfer payments have a negative impact on the overall income of rural poor households. This can be attributed to a decrease in labor supply among rural poor residents who receive such payments, resulting in reduced wage income. Additionally, transfer payments lead to decreased expenditure on food and increased spending on healthcare. These changes in total income and consumption patterns indicate that China’s current transfer payment policy has short-term efficacy by meeting the basic living security needs of rural poor residents and improving their health conditions. However, the lack of significant changes in education spending suggests that transfer payments have little long-term effect.
Research on the bidirectional motion of resonant single-wing bionic piezoelectric motor based on a biasing self-clamping mechanism
Authors: He Liangguo , Qian An , Li Xinyu , Yue Xukang , Wan Zhikai , Huang Liang 
Published: December 2023

Based on our previous research, this article adds new research content and further refines the previous research on bionic motors. It is in the form of note as a complementary improvement to the previous article. This article proposes a novel approach to achieving reversal motion in such motors driven by a single harmonic signal, specifically the multimode mode of the vibrator. In contrast to the conventional inertial impact piezoelectric motor, we propose a bidirectional piezoelectric motor that can achieve bidirectional motion only by altering the driving signal characteristics. Compared to other bidirectional piezoelectric motors, this motor features a simpler structure and more convenient control. The COMSOL6.0 finite element analysis software was utilized to optimize the working mode of the piezoelectric motor, and an experimental platform was constructed for testing and verifying the performance of the designed prototype. The final experimental data demonstrate that, with an excitation voltage of 300 Vp-p, a preload of 2 N, and an excitation frequency of 781 Hz, the motor prototype achieves a maximum no-load speed of 12.15 mm/s, a maximum resolution of 15.27 μm, and a maximum load of 14 g. These results confirm the validity of the new working mode.
Constructions of the soliton solutions to coupled nonlinear Schrödinger equation with advanced mathematical techniques
Authors: Alharbi Taghread Ghannam , Alharbi Abdulghani 
Published: December 2023

In our research paper, we explore the application of mathematical techniques, both analytical and numerical, to solve the coupled nonlinear Schrödinger equation. To obtain accurate solutions, we use the improved, modified, extended tanh-function method. By breaking down the Schrödinger equation into real and imaginary components, we derive four interconnected equations. We analyze these equations using the generalized tanh method to find precise solutions. This set of equations is of great importance in quantum mechanics and helps us understand the behavior of quantum systems. We provide an analytical and numerical solution using the implicit finite difference. Our method is second-order in both space and time, and we have verified its stability through von Neumann’s stability analysis.
Dynamic micromechanical measurement of the flexural modulus of micrometre-sized diameter single natural fibres using a vibrating microcantilever technique
Authors: Reda Ali , Dargent Thomas , Arscott Steve 
Published: December 2023

Abstract
The dynamic response of a structure is a manifestation of its inherent characteristics, including material density, mechanical modulus, thermo- and viscoelastic properties, and geometric properties. Together, these factors influence how the material behaves in dynamic scenarios, dictating its damping properties and behaviour under varying forces. In this study we present a novel approach to accurately determine the flexural (bending) modulus of microscopic diameter natural fibres (flax) using microcantilever vibration analysis. Traditionally, the characterisation of the mechanical properties of fibres has relied on macroscopic methods such as tensile testing, which often results in high scatter in measurement data; furthermore, tensile testing does not accurately represent microscale or dynamic conditions and can be complex in terms of sample preparation and loading. To address this, we have developed a microscale technique involving the fabrication of microcantilevers using flat polypropylene support chips, inspired by microelectromechanical systems approaches. Our method provides a refined method for accurately characterising the mechanical modulus of flax fibres, with reduced data dispersion compared to traditional macroscopic testing. Furthermore, by reducing the influence of inherent fibre defects and maintaining homogeneity along the length of the fibre, our micro-scale technique provides reliable modulus determination. This work opens avenues for improved understanding and application of natural and man-made fibres, such as glass and optical fibres, in a variety of fields.
Combining the D3 dispersion correction with the neuroevolution machine-learned potential
Authors: Ying Penghua , Fan Zheyong 
Published: December 2023

Abstract
Machine-learned potentials (MLPs) have become a popular approach of modeling interatomic interactions in atomistic simulations, but to keep the computational cost under control, a relatively short cutoff must be imposed, which put serious restrictions on the capability of the MLPs for modeling relatively long-ranged dispersion interactions. In this paper, we propose to combine the neuroevolution potential (NEP) with the popular D3 correction to achieve a unified NEP-D3 model that can simultaneously model relatively short-ranged bonded interactions and relatively long-ranged dispersion interactions. We show that improved descriptions of the binding and sliding energies in bilayer graphene can be obtained by the NEP-D3 approach compared to the pure NEP approach. We implement the D3 part into the gpumd package such that it can be used out of the box for many exchange-correlation functionals. As a realistic application, we show that dispersion interactions result in approximately a 10% reduction in thermal conductivity for three typical metal-organic frameworks.
Parity of polaritons in a molecular aggregate coupled to a single-mode cavity
Authors: Liu Jingyu , Liu Jiani , Yao Yao 
Published: December 2023

Abstract
We investigated the parity of polaritons, particularly the parity of topological polariton states resulting from light fields, in a molecular aggregate with uniform and alternating excitation transfer interaction coupled to a single-mode cavity. We find that all polariton states are with even parity, in terms of parity conservation, and the even-parity edge states of the Su–Schrieffer–Heeger model with alternating excitation transfer interaction induce even-parity topological polariton states. Thus, the odd-parity edge states are almost unaffected. The original odd-parity edge state is then affected with respect to the parity non-conservation case, i.e. the occupation number of the edge states shifts from one edge to another. This result entails the preparation of edge states from the photonic excited states through an adiabatic process.
Development and validation of BVB-UIE: an underwater image-enhancement model with two-layer deep neural network
Authors: Yao Xinyu , He Fengtao , Bai JuRong , Zhang Jianlei 
Published: December 2023

Abstract
Due to the absorption and scattering of light in water, underwater visual visibility is poor, and underwater images usually suffer from color distortion and feature loss, which poses a great challenge for underwater vision tasks. To handle these issues, we present an underwater image enhancement (UIE) method. A Gaussian pyramid is constructed for the degraded underwater images based on an improved visual saliency model, with the characteristics of luminance, orientation, texture, and color. By combining channel and spatial attention mechanisms, a deep asymmetric feature enhancement network is built to preserve the high-dimensional features of the image. In addition, a polynomial loss function is used for the depth hopping supervising constraints during the enhancement process, and the gating signals are employed to control the importance of the features at different spatial locations. These innovations maximize the efficiency of the feature extraction while simplifying the network complexity. Experiments on an open benchmark dataset for UIE show that our method effectively eliminates the color bias and contrast distortion problems while preserving the complex image details compared to the existing UIE algorithms. Objective metrics show a significant improvement in the algorithm, with a 15% increment in the peak signal-to-noise ratio metric compared to the closest competing algorithm.