bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Precise and Intelligent Nanomedicine for Salivary Adenoid Cystic Carcinoma Treatment by Combining Antivascular Photodynamic Therapy and Neuroinhibitory Chemotherapy
Authors: Chen Qian , Han Lu , Wu Jiaxin , Cheng Yuanyuan , Bai Liya , Qian Zhanyin , Yang Meng , Liu Xingkun , Wang Yinsong 
Published: December 2023

AbstractSalivary adenoid cystic carcinoma (SACC) is one of the most common salivary gland malignancies. Current clinical therapies have limitations and cannot efficiently prevent the SACC development and metastasis. Hematogenous and neural spread are the two major routes of SACC metastasis. In this study, a precise and intelligent nanomedicine, RCDT, is designed to combine antivascular photodynamic therapy and neuroinhibitory chemotherapy against SACC. A tumor vessel‐targeted and reactive oxygen species (ROS)‐responsive photosensitizer (RC) is synthesized by linking cRGD to chlorin e6 (Ce6) via a bridge between the poly(ethylene glycol) and diselenide bonds. A neural‐targeted and pH‐responsive cytotoxic prodrug (DT) is synthesized by conjugating doxorubicin (DOX) with Tet1, a neural‐targeting peptide, via an acidic‐cleavable hydrazone bond. RC and DT are assembled to form RCDT via hydrophobic interactions, thereby shielding Tet1. Under the guidance of cRGD and the photodynamic action of Ce6, RCDT can precisely disrupt the tumor vasculature and simultaneously disintegrate to expose Tet1 by rupturing the diselenide bond. Guided by Tet1, disintegrated RCDT can be specifically internalized into neurons and release DOX to exert neuroinhibitory effects by cleaving the hydrazone bond. Using these stepwise dual‐targeting and dual‐responsive strategies, RCDT can efficiently suppress the growth and metastasis of SACC.
Highly Sensitive Diagnosis of Extracellular Calcium Ions Associated Brain Diseases using Ca2+‐Dependent T2‐T1 Switchable Magnetic Nanosensors
Authors: Wang Qiyue , Wang Tao , Yang Shengfei , Du Hui , Zhang Bo , Cui Sirui , Ling Daishun , Li Fangyuan 
Published: December 2023

AbstractCalcium ions (Ca2+) play crucial roles as second messengers in living cells and are associated with the onset and development of chronic brain diseases, including epilepsy. Dynamic and real‐time imaging of extracellular calcium levels ([Ca2+]ex) in the brain holds great potential for identifying disease foci. Magnetic resonance imaging (MRI) is a powerful non‐invasive tool for Ca2+ imaging with unlimited depth penetration. However, current available Ca2+ MR sensors lack the sensitivity to monitor small [Ca2+]ex alterations associated with chronic brain diseases in vivo. In this study, a highly sensitive Ca2+‐dependent T2‐T1 switchable magnetic nanosensor is reported, consisting of Ca2+‐specific ligands engineered near‐paramagnetic iron oxide nanoparticles. Surface ligand modifications can be adjusted to regulate the interaction energy between sensors and Ca2+, allowing for customizable response range and sensitivity to fulfill the in vivo imaging requirements. The optimized sensors enable non‐invasive visualization of early‐stage seizure focus in mice undergoing epilepsy.
Revealing the Untapped Potential of Photocatalytic Overall Water Splitting in Metal Organic Frameworks
Authors: Wang Caihua , Wan Yangyang , Yang Shaokang , Xie Yuee , Chu Shibing , Chen Yuanping , Yan Xiaohong 
Published: December 2023

AbstractThe past decade witnessed substantial attention toward metal‐organic frameworks (MOFs) for photocatalytic water splitting owing to their versatile structural and optoelectronic characteristics. However, MOFs capable of efficient photocatalytic overall water splitting (OWS) remain notably scarce. Although MOF‐based photocatalysts with OWS potential are highly promising due to their diverse building blocks and topological configurations, the vast number of possible MOFs renders traditional trial‐and‐error materials discovery approaches impractical. Herein, a data‐driven methodology that integrates machine learning with high‐throughput first‐principles computations to identify MOFs with OWS capability is presented. By systematically assessing factors including water stability, band gap, band positions, charge carrier transport, and optical absorption properties, 14 MOFs from the Quantum‐MOF (QMOF) database containing over 20,000 MOFs as promising candidates for visible‐light‐driven OWS are identified. Notably, five of them exhibit exceptional electronic and optical properties, outperforming previously reported MOF OWS photocatalysts, such as UIO66(Zr)‐NH2, MIL125(Ti)‐NH2, and MIL53(Al)‐NH2 is established. This work represents a large‐scale, data‐driven exploration of MOF‐based photocatalysts for water splitting, shedding light on the untapped potential of photocatalysis in MOFs.
Liquid Metal Powders Wrapped with Robust Shell by Bimetallic Ions Chelation Strategy for Energy Harvesting and Flexible Electronics
Authors: Qi Xiulei , Yu Lei , Liu Yide , Chen Long , Li Xiankai 
Published: December 2023

AbstractExcellent electrical and fluidic properties render liquid metal (LM) a promising material for flexible electronics, soft robotics, and stretchable circuits. Although producing LM micro/nano droplets by nanometerization addresses the tricky issue of the processing result from high surface tension, it still remains challenging to obtain stable LM droplets because of their dynamic surfaces. In this study, LM powders wrapped with robust shells are fabricated by bimetallic ions chelation strategy. During sonicating LM (e.g., EGaIn) in an alginate solution, a microgel shell is first formed by the coordination of Ga3+ and carboxyl groups. Subsequently, LM powders are achieved by introducing Ca2+ as secondary metal ions to chelate with redundant carboxyl groups. Besides high chemical stability in water and air, these nonstick LM powders also exhibit superior photothermal effects for energy harvesting, being capable of recovering electrical conductivity by mechanical sintering for flexible electronics. These conductive circuits based on LM powders not only work as electro‐thermal heaters, and electromagnetic interference shielding material but also can be designed as smart actuators. Thus, this bimetallic ions chelation strategy may start a pathway to produce stable, transportable LM powders with multifunctional properties, applicable in stretchable electronics, smart actuators, and electric skins.
Porous Titanium Scaffolds with Mechanoelectrical Conversion and Photothermal Function: A Win‐Win Strategy for Bone Reconstruction of Tumor‐Resected Defects
Authors: Tang Zhen , Yu Dongmei , Bao Shusen , Li Chenyu , Wu Hao , Dong Hui , Wang Ning , Liu Yichao , Wu Qi , Chen Changcheng , Wang Mo , Cao Pengfei , Zheng Zenghui , Huang Hai , Li Xiaokang , Guo Zheng 
Published: December 2023

AbstractBone metastases severely threaten the lives of patients. Although surgical treatment combined with adjuvant chemotherapy significantly improves the survival rate of patients, tumor recurrence, or metastasis after surgical resection and bone defects caused by surgical treatment remain major challenges for clinicians. Given the abovementioned clinical requirements, barium titanate‐containing iron‐coated porous titanium alloy scaffolds have been proposed to promote bone defect repair and inhibit tumor recurrence. Fortunately, in vitro and in vivo experimental research confirms that barium titanate containing iron‐coated porous titanium alloy scaffolds promote osteogenesis and bone reconstruction in defect repair via mechanoelectric conversion and inhibit tumor recurrence via photothermal effects. Furthermore, the underlying and intricate mechanisms of bone defect repair and tumor recurrence prevention of barium titanate‐containing iron‐coated porous titanium alloy scaffolds are explored. A win‐win strategy for mechanoelectrical conversion and photothermal functionalization provides promising insights into bone reconstruction of tumor‐resected defects.
Vacancy Defects Inductive Effect of Asymmetrically Coordinated Single‐Atom Fe─N3S1 Active Sites for Robust Electrocatalytic Oxygen Reduction with High Turnover Frequency and Mass Activity
Authors: Zhao Yilin , Chen Hsiao‐Chien , Ma Xuelu , Li Jiaye , Yuan Qing , Zhang Peng , Wang Minmin , Li Junxi , Li Min , Wang Shifu , Guo Han , Hu Ruanbo , Tu Kun‐Hua , Zhu Wei , Li Xuning , Yang Xuan , Pan Yuan 
Published: December 2023

AbstractThe development of facile, efficient synthesis method to construct low‐cost and high‐performance single‐atom catalysts (SACs) for oxygen reduction reaction (ORR) is extremely important, yet still challenging. Herein, an atomically dispersed N, S co‐doped carbon with abundant vacancy defects (NSC‐vd) anchored Fe single atoms (SAs) is reported and a vacancy defects inductive effect is proposed for promoting electrocatalytic ORR. The optimized catalyst featured of stable Fe─N3S1 active sites exhibits excellent ORR activity with high turnover frequency and mass activity. In situ Raman, attenuated total reflectance surface enhanced infrared absorption spectroscopy reveal the Fe─N3S1 active sites exhibit different kinetic mechanisms in acidic and alkaline solutions. Operando X‐ray absorption spectra reveal the ORR activity of Fe SAs/NSC‐vd catalyst in different electrolyte is closely related to the coordination structure. Theoretical calculation reveals the upshifted d band center of Fe─N3S1 active sites facilitates the adsorption of O2 and accelerates the kinetics process of *OH reduction. The abundant vacancy defects around the Fe─N3S1 active sites balance the OOH* formation and *OH reduction, thus synergetically promoting the electrocatalytic ORR process.
Bioinkjet Printing and Protein Tagging of Camouflaged Biosafe Quick Response Codes for Medicine Authentication
Authors: Kim Joshua J. , Ji Yuhyun , Guo Denny L. , Kim Young L. , Leem Jung Woo 
Published: December 2023

AbstractOnline pharmacies and social media platforms are responsible for the growing presence of counterfeit medicines, and the verification and authentication of dosage levels are imperative for protecting individual medicines. However, the existing anticounterfeit methods for medicines and exterior box‐level protection are often limited, and they focus on pharmaceutical supply chains instead of empowering patients. Here, bioprinting and taggant construction of camouflaged biosafe quick response (QR) codes are introduced for on‐dose (or in‐dose) medicine security, integrated with the dosage form. Machine‐readable color QR codes contain concealed invisible patterns with biologically safe near‐infrared absorption properties, which help enhance the security of conventional QR codes. The reported bioinkjet printing and protein taggant construction guarantee printability, imperceptibility, stability, biocompatibility, digestibility, and tamper resistance to be an inherent part of each unit of medicine in solid dosage formats. Camouflaged biosafe QR code taggants can offer various medicine security applications including anticounterfeit measures, authentication features, track‐and‐trace, and serialization at the dosage level. This approach is expected to empower patients to play an active role in fighting illicit medicines and pharmaceutical products.
Synthesis and Characterization of High‐Quality Ta2O5 Nanoparticles for Highly Selective SAW‐Based DUV Sensor and Corona Detection Application
Authors: Kim Sihyeok , Nawaz Faisal , Choi Cheol , Jeon Il , Lee Keekeun 
Published: December 2023

AbstractIn recent times, significant progress is made in the development of solar‐blind deep‐ultraviolet (DUV) photodetectors (200–280 nm) due to their potential applications for military and civil purposes. In this study, the development of a novel solar‐blind DUV photodetector based on tantalum pentoxide (Ta2O5) nanoparticles (NPs) utilizing Surface Acoustic Wave (SAW) sensor integrated with Interface electronics is reported for the first time. The 3‐D Ta2O5 NPs surface morphology, crystallinity, and defect state level is discussed using various analytical techniques, including scanning electron microscope (SEM), X‐ray diffraction (XRD), and spectrophotometer. The developed 3‐D Ta2O5 NPs based photodetector exhibits high sensitivity to 254 nm DUV irradiation (5 µW cm−2), demonstrating excellent photoresponse characteristics. The performance parameters including highest sensitivity, fast response/recovery time are measured as 1621.1 ppm (mW cm−2)−1, 3.7s/19.8s, respectively. Subsequent analysis demonstrates the stability and repeatability of the photodetector, enabling its potential to real time corona discharge detection. With its inherent advantages, the current DUV photodetector utilizing Ta2O5 NPs exhibits great potential for future applications in DUV optoelectronics.
Ternary Liquid Metal Polymer Composite for Stretchable Electronics
Authors: Luo Zheng , Zhou Xiaoping 
Published: December 2023

AbstractThe small strain characteristics of the traditional flexible conductive composites hinder their realization of skin‐like properties and multi‐scenario applications. The value of liquid metal (LM)‐based elastomers is demonstrated in flexible electronics. Attempts in this area include the development of multifunctional LM‐based elastomers with controllable morphology, superior mechanical performances, and excellent stability. In this work, an efficient strategy is proposed to achieve the fast preparation of the LM patch by uniformly distributing eutectic gallium–indium–tin alloy in deionized water and by constructing the LM‐iron particles‐Ecoflex (LMIE) ternary composite system. In this study, the fabricated LMIE large strain sensor exhibits high sensitivity (the gage factor (GF) = 0.98 when strain ranges from 0% to 60%; GF = 1.91 when strain ranges from 60% to 100%), high linearity (correlation coefficient (R2) = 0.96 when strain ranges from 0% to 60%; R2 = 0.99 when strain ranges from 60% to 100%), a wide strain range of detection (e.g., 1%–100%) and breaking elongation (e.g., 450%), a fast response time (80 ms), excellent repeatability and stability. This work exhibits the excellent potential of multifunctional liquid metal composites in wearable electronics and prediction devices of structural collapse.
Super‐Resolution Imaging via Lenses with Angular Magnification
Authors: Zhou Yi , Ma Zijie , Liao Dingpeng , Zhang Kun , Wu Shikai , Ma Jun , Dai Xuemei , Shang Zhengguo , Wen Zhongquan , Chen Gang 
Published: December 2023

AbstractThe far‐field resolution of traditional optical imaging systems is restricted by the Abbe diffraction limit, a direct result of the wave nature of light. To break this limit, one applicable approach is to reduce the effective size of the point‐spread‐function (PSF). In the past decades, great endeavors have been made to produce an effective super‐resolution PSF by exploiting different mechanisms, including optical nonlinearities and structured light illumination. However, it is difficult to apply these methods to objects at far distance miles away. Here, the study proposes a new approach to achieving super‐resolution imaging for far‐distance objects by utilizing angular magnification. To this end, a new class of metalenses with angular magnification is first theoretically and experimentally validated and demonstrated. Both theoretical and experimental results have demonstrated a more than twofold enhancement beyond the traditional angular‐resolution limit. The proposed approach is of promising potential in the applications of super‐resolution telescopes and remote sensing.
Chromium Cluster Luminescence: Advancing Near‐Infrared Light‐Emitting Diode Design for Next‐Generation Broadband Compact Light Sources
Authors: Rajendran Veeramani , Chang Chih‐Yu , Huang Ming‐Hsuan , Chen Kuan‐Chun , Huang Wen‐Tse , Kamiński Mikołaj , Lesniewski Tadeusz , Mahlik Sebastian , Leniec Grzegorz , Lu Kuang‐Mao , Wei Da‐Hua , Chang Ho , Liu Ru‐Shi 
Published: December 2023

AbstractIn modern technology devices, an energy‐saving miniature near‐infrared (NIR) light source plays a critical role in non‐destructive, non‐invasive sensing applications and further advancement of technology. This paper reports the broadband NIR luminescence of Cr3+ clusters for designing phosphor‐converted NIR light‐emitting diodes as an alternative to typical isolated Cr3+ centers and Cr3+ ion pairs. Here, Cr3+ clusters form in the intermediate spinel structure of MgGa2O4 by utilizing the long‐chain edge‐shared octahedral dimers with the shortest bond distance between Cr3+ cations. Electron paramagnetic and magnetometry measurements confirm the isolated Cr3+ and Cr3+ clusters, resulting in NIR luminescence with three distinct emission centers. The formation of Cr3+ clusters in MgGa2O4 ensures stable internal quantum efficiency (≈94%), full‐width‐half‐maximum (248 nm), thermal stability (87%), and a radiant flux of ≈17.66 mW. This work offers a promising approach to NIR phosphor design and enhances the understanding of luminescence mechanisms in spinel and related structures.
Photocatalyst‐ and Transition‐Metal‐Free Light‐Induced Formation of Carbon‐Chalcogen Bonds
Authors: Bhanja Rosalin , Bera Shyamal Kanti , Mal Prasenjit 
Published: December 2023

AbstractPhotoinduced chemical transformations have become a promising aspect of organic synthesis. This review focuses on the recent advancements in harnessing photoinduced processes for the formation of carbon‐chalcogen (C−O, C−S, C−Se, and C−Te) bonds under catalyst‐free conditions. These pathways typically involve either a radical mechanism or the creation of electron‐donor‐acceptor (EDA) complexes. The review explores the intricacies of the underlying mechanisms, discusses limitations, and evaluates the applicability of various methodologies in this field. Notably, photocatalyst and transition metal‐free photochemical reactions offer effective alternatives to enhance sustainability in this research area.
Modelling Radiative Coolers for the Built Environment in the Urban Context
Authors: Kousis Ioannis , Martilli Alberto , Pisello Anna Laura 
Published: December 2023

AbstractRadiative Coolers (RCs) represent an emerging technology that has the potential to significantly reduce urban heat and improve indoor/outdoor thermal comfort in the built environment. Broadband and Selective Radiative Coolers (BRCs and SRCs, respectively) are the two main types of RCs that have been proposed for application in the built environment. Being both typically characterized by high solar reflectance, the former emits thermal radiation within the overall infrared spectrum, whilst the latter emits thermal radiation mainly within the Atmospheric Window (AW) waverange. A variety of both types of RCs have been developed and tested in both in‐lab and in‐field experimental campaigns. Yet, all experiments comprise small scale specimens that do not represent real‐life scale components of the built environment. In addition, no meso scale assessments have been performed with respect to the RCs' performance at a city scale. Here, for the first time, the thermo‐optical performance of both BRCs and SRCs is introduced and investigated in a multilayer Urban Canopy Model (UCM) coupled with extended Weather Research and Forecasting model (WRF) and we simulated 20 different scenarios representing the vast majority of urban layouts. The outcomes show that both types of RCs maintain lower surface temperature and air temperature at 2 m height inside the canyon, compared to conventional roofs. In addition, a city scale application of RCs has been found capable of decreasing ambient temperature up to 1.6°C as potentially experienced by pedestrians.
Responsive Nanomaterial Delivery Systems for Pancreatic Cancer Management
Authors: Elsherbeny Amr , Bayraktutan Hulya , Oz Umut Can , Moloney Cara , Ashworth Jennifer C. , Grabowska Anna M. , Alexander Cameron 
Published: December 2023

AbstractPancreatic cancer is characterized by a high mortality rate and unfavorable prognosis. This is primarily attributed to poor accumulation of therapeutic agents at the target site due to the presence of a highly complex tumor microenvironment surrounding the pancreatic cancer tissue. However, a promising avenue for targeted drug delivery has emerged in the form of stimuli‐responsive materials. These advanced nanocarriers, encompassing both external and internal stimuli‐responsive nanoparticles, can be formulated to control the release of therapeutic agents precisely in response to specific activation. By harnessing external stimuli such as light, ultrasound, or magnetic fields, as well as intrinsic biological triggers including pH, redox potential, hypoxia, and temperature, these nanomaterials exhibit ‘intelligent’ and selective responses within complex biological environments. These responsive nanoparticles have been shown to address challenges associated with poor vascularity and thick desmoplastic stromal layers, which are hallmarks of pancreatic cancer, by promoting enhanced drug accumulation and release at the target site relative to conventional therapy. This work explores the design strategies for advanced stimuli‐responsive nanomaterials, integrating both internal and external stimuli, with the potential to enhance drug delivery efficacy in pancreatic cancer. It addresses the challenges and prospects in their development and offers insights for future clinical applications.
Modeling and Analyzing Information Propagation Evolution Integrating Internal and External Influences
Authors: Yin Fulian , She Yuwei , Wang Jinxia , Wu Yuewei , Wu Jianhong 
Published: December 2023

AbstractOnline social networks have revolutionized communication, providing individuals with platforms to express their personal opinions on diverse topics. Researchers have independently explored information propagation and opinion evolution within complex networks. However, these phenomena exhibit interconnectedness, where information dissemination influences opinion evolution and vice versa. To address challenges in complex network modeling and opinion‐information coupling, internal and external factors are considered in public opinion scenarios by incorporating the crowd effect, enhancement effect, and evolutionary game theory. The susceptible‐latent‐forwarding‐immune‐Jager‐Amblard (SLFI‐JA) model is presented by modifying the SLFI propagation dynamics model and the JA opinion dynamics model, enabling the integration of information propagation and opinion evolution at the microlevel. Through analyzing real‐world social hotspots on Sina Weibo, case studies and comparative analyses are conducted to validate the rationality and effectiveness of the proposed model. Furthermore, the findings identify key factors influencing public opinion dissemination and group opinion evolution, offering valuable insights to relevant departments in public opinion response and management. The study aims to mitigate the harmful effects of negative public opinions, prevent extreme adverse online events, and foster a healthier online environment.