bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unleashing the Zoological Tapestry: Animals Eponyms in Dermatology Revealing Nature’s Influence on Skin Diseases
Authors: Kololgi Shreyas P. , Hulmani Manjunath , Lahari C. S. 
Published: January 2024

Abstract
The dermatological canvas, often considered the storyteller of human health, is imbued with narratives that intertwine with the very essence of the natural world. A mesmerizing facet of this narrative is found in “animals eponyms” – enigmatic skin conditions christened after animals whose traits mimic the intricate nuances of these dermatological tales. Delving into this realm unveils a tapestry where medicine and nature dance in synchrony, encapsulating both the artistry and science of dermatology. Animals eponyms offer a unique bridge between dermatology and the natural world. They serve as memorable tools for recognizing and diagnosing dermatological conditions while embodying the fascinating connection between humans and the animal kingdom. By examining these eponyms, dermatologists gain a deeper understanding of the intricate relationship between medicine and nature, ultimately enhancing patient care through enhanced diagnostic acumen.
Effect of Boron on Sympathetic Skin Response in Rats
Authors: Boyuk Gulbahar , Dolu Nazan , Aksoy Busra 
Published: January 2024

Abstract

Background:
Boron effects on reproduction and growth have been extensively studied in animals. Electrodermal activity (EDA) reflects the activity of eccrine sweat glands stimulated by the release of acetylcholine from sympathetic nerves.

Aim:
In the presen study, it was aimed to examine the effect of boron, which was turned into cream, on sweat glands.

Methods:
A cream form mixed with thyme oil was prepared for EDA recording. Our groups were formed as EDA recording gel (Group 1), cream with thyme oil (Group 2), cream containing 10% boron (Group 3) and cream containing 30% boron (Group 4). In each group, 3 months old, 10 male rats were used, and creams were applied to the soles of the hind extremities of the rats, EDA was recorded from this region after half an hour, and skin conductivity levels (SCL) were recorded as tonic (at rest) and phasic (with auditory sound stimulation).

Results:
EDA results recorded in the morning were analysed with tonic and phasic recordings. In the morning SCL measurements, tonic SCL value of Group 4 was higher than the other groups (P < 0.001). Although the phasic SCL value was measured, it was significantly higher in Group 4 than in all groups (P < 0.0s).

Conclusion:
EDA measurements showed that boron increased sweat gland activity by increasing sympathetic nerve activity.
New-Onset and Exacerbation of Psoriasis following COVID-19 Vaccination: A Systematic Review of Case Reports and Case Series
Authors: Arifin Aisyah N. F. , Hengky Antoninus , Widjaja Maureen , Wijaya Lorettha 
Published: January 2024

Abstract

Introduction:
Although uncommon, several cases of new-onset and exacerbation of psoriasis have been reported after coronavirus disease 2019 (COVID-19) vaccination. This study aims to systematically review reports regarding new-onset and exacerbation of psoriasis to identify features related to that condition following COVID-19 vaccination.

Materials and Methods:
Three databases were utilised, namely, PubMed, Google Scholar, and EBSCOHost to search for literature published until June 2022. We used the following MeSH terms: “psoriasis,” “exacerbation,” “induced psoriasis,” and “COVID-19 vaccination.” The included literature must report the case/(s) of psoriasis exacerbation in previously-in-remission or induced psoriasis in individuals receiving any dose of COVID-19 vaccines regardless of the type.

Results:
Among 33 selected studies, an overall mean age was 57.52 ± 15.92 years. Female (n = 40; 54.8%) was more frequently reported than male (n = 33; 45.2%). In terms of vaccine types, Pfizer is the most commonly reported (49 cases; 67.1%), followed by Astra-Zeneca (13 cases; 17.8%), Moderna (10 cases; 13.7%), and CoronaVac (1 case; 1.4%). The onset of psoriasis after receiving the COVID-19 Vaccines was varied, ranging from 1 to 90 days (Mean ± SD: 15.75 ± 18.22). Plaque psoriasis was most commonly reported, followed by pustular, guttate and other types of psoriasis. Reported cases were frequently treated with topical steroids and monoclonal antibodies monotherapy.

Conclusions:
Although the cases of new-onset and exacerbation of psoriasis after COVID-19 vaccination is quite scarce, the possibility of occurrence should be acknowledged and managed properly; and patients should be informed, particularly ones with history of psoriasis without discouraging patients to take vaccine.
Cancer-associated retinopathy as an initial presentation of gynecologic small-cell carcinoma
Authors: Fang Hwa-Shin , Yang Chang-Sue , Cheng Cheng-Kuo , Wang Yuan-Shen 
Published: January 2024

Abstract:
A 56-year-old female presented with bilateral progressive blurred vision over 1 month. She has no known malignancy before her initial visit to our ophthalmologic clinic. Her best-corrected visual acuity decreased to hand motion from 30 cm in both eyes. Optical coherence tomography exhibited parafoveal thinning of outer retinal layers bilaterally. Fluorescein angiography and indocyanine green angiography disclosed hypofluorescent spots in late phase in both eyes. The suspicion of cancer-associated retinopathy (CAR) prompted us to investigate and refer for further systemic disease including occult malignancy. The patient was diagnosed with small-cell carcinoma of the endometrium or cervix, which is an extremely rare and aggressive neuroendocrine tumor. The patient was treated with oral prednisone with improved visual acuity. The patient expired from sepsis 2 months after her initial visit to our ophthalmologic clinic. In selected cases, CAR may present before the diagnosis of primary cancer. It is essential to recognize its ophthalmic manifestation for early discovery of primary malignancy.
Prognostic significance and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer: A clinicopathological study
Authors: Lv Shi-Lin , Guo Pei , Zou Jun-Rong , Chen Ren-Sheng , Luo Ling-Yu , Huang De-Qiang 
Published: January 2024

BACKGROUND
The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer metastasis. SMAD3 phosphorylation is a crucial prognostic marker in gastric cancer.
AIM
To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer.
METHODS
This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years (median age 65) between July 2006 and April 2007. Patients were followed up until death or the study ended (median follow-up duration of 28.5 mo). The samples were used to generate tissue microarrays (TMAs) for immunohistochemical (IHC) staining. The expressions of TGF-β1, pSMAD3C(S423/425), pSMAD3L(S204), and VEGFR-1 in gastric cancer (GC) tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC patients. Prognosis and survival information of the patients was recorded by Outdo Biotech from May 2007 to July 2015. The relationship between TGF-β1, pSMAD3C(S423/425), pSMAD3L(S204), and VEGFR-1 protein expression levels was analyzed using Pearson's correlation coefficient. The relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test. A survival curve was generated using the Kaplan-Meier survival analysis.
RESULTS
TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent non-cancerous tissue. The positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site [pSMAD3C(S423/425): 51.0% and pSMAD3L(S204): 31.6%]. High expression of pSMAD3L(S204) was significantly correlated with larger tumors (P = 0.038) and later N stages (P = 0.035). Additionally, high expression of VEGFR-1 was closely correlated with tumor size (P = 0.015) and pathological grading (P = 0.013). High expression of both pSMAD3L(S204) and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival (OS). Multivariate analysis indicated that high expression of pSMAD3L(S204) and VEGFR-1 were independent risk factors for prognosis in GC patients. VEGFR-1 protein expression was correlated with TGF-β1 (r = 0.220, P = 0.029), pSMAD3C(S423/425) (r = 0.302, P = 0.002), and pSMAD3L(S204) (r = 0.201, P = 0.047), respectively. Simultaneous overexpression of pSMAD3L(S204) and VEGFR-1 was associated with poor OS in gastric cancer patients.
CONCLUSION
Co-upregulation of pSMAD3L(S204) and VEGFR-1 can serve as a predictive marker for poor gastric cancer prognosis, and pSMAD3L(204) may be involved in enhanced gastric cancer metastasis in a VEGFR-1-dependent manner.
Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer: A meta-analysis
Authors: Yuan Mao-Xiu , Cai Qi-Gui , Zhang Zhen-Yang , Zhou Jian-Zhong , Lan Cai-Yun , Lin Jiang-Bo 
Published: January 2024

BACKGROUND
The effectiveness of neoadjuvant therapy in esophageal cancer (EC) treatment is still a subject of debate.
AIM
To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy (nCRT) and neoadjuvant chemotherapy (nCT) for locally advanced EC (LAEC).
METHODS
A comprehensive search was conducted using multiple databases, including PubMed, EMBASE, MEDLINE, Science Direct, The Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Journal Database, and Chinese Biomedical Literature Database Article. Studies up to December 2022 comparing nCRT and nCT in patients with EC were selected.
RESULTS
The analysis revealed significant differences between nCRT and nCT in terms of disease-free survival. The results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate (OSR) [odds ratio (OR) = 0.95], complete response rate (OR = 3.15), and R0 clearance rate (CR) (OR = 2.25). However, nCT demonstrated a better 5-year OSR (OR = 1.02) than nCRT. Moreover, when compared to nCRT, nCT showed reduced risks of cardiac complications (OR = 1.15) and pulmonary complications (OR = 1.30).
CONCLUSION
Overall, both nCRT and nCT were effective in terms of survival outcomes for LAEC. However, nCT exhibited better performance in terms of postoperative complications.
Categorical absorptions of singularities and degenerations
Authors: Kuznetsov Alexander , Shinder Evgeny 
Published: January 2024

We introduce the notion of categorical absorption of singularities: an operation that removes from the derived category of a singular variety a small admissible subcategory responsible for singularity and leaves a smooth and proper category. We construct (under appropriate assumptions) a categorical absorption for a projective variety $X$ with isolated ordinary double points. We further show that for any smoothing $\mathcal{X}/B$ of $X$ over a smooth curve $B$, the smooth part of the derived category of $X$ extends to a smooth and proper over $B$ family of triangulated subcategories in the fibers of $\mathcal{X}$.Comment: 41 pages; v2, v3: minor improvements, v4: revised according to the referee's report, to appear in EPIGA, v5: published version
Estudio de la eficacia del dispositivo de fijación orotraqueal leandro en recien nacidos, lactantes y niños
Authors: Morales Aida Lanza , Arias Judith Veizaga , Ponce Susana Bravo , Poma Nancy Mamani , Yucra Marcelina Barrios 
Published: January 2024

El mayor agradecimiento a la vida es el de contribuir a preservar y respetar la misma es así que un grupo de profesionales de Enfermería liderizado por la autora intelectual diseñaron y aplicaron un dispositivo para sustituir las técnicas empleadas en la actualidad por un dispositivo asistencial y de fijación a partir del reflejo de succión y deglución. Se aplicó el enfoque cualitativo y cuantitativo o método mixto porque se recopiló datos de amplia profundidad a partir del diseño experimental donde la observación, manipulación y registro de las variables fue realizado en torno al objeto de estudio. La muestra estuvo compuesta por 41 niños en los cuales se aplicó de forma experimental el dispositivo con un instrumento de 10 ítems, validado por expertos. El análisis de los datos se realizó utilizando las estadísticas descriptivas seguida del análisis de las variables cuantitativas y variables cualitativas Los resultados evidencian la eficacia del dispositivo en el procedimiento de fijación del tubo endotraqueal observados y evaluados por profesionales de enfermería quienes evidenciaron el buen estado del dispositivo y sus partes evitando así lesiones en la piel, deslizamiento del tubo o extubación accidental en el 100% de los casos, por lo que en términos de eficiencia muestra una alta eficacia caracterizado por la responsabilidad social valores ético morales y respeto a la vida.
Implementasi E-Desa Untuk Meningkatkan Kualitas Pelayanan Masyarakat Teluk Buyung
Authors: Nawangsih Ismasari , Budi Rahardjo Sugeng 
Published: January 2024

Abstrak− E-desa merupakan sistem informasi online yang digunakan untuk pelayanan kepada masyarakat. Desa Telukbuyung, Pakis Jaya Kerawang yang rata-rata masyarakatnya berprofesi sebagai petani. Tata letak kantor desa yang strategis dari tempat tinggal masyarakat. Perangkat desa mempunyai kendala dalam memberikan informasi dan pelayanan tentang kegiatan desa kepada masyarakat. Perangkat desa turun langsung bila ada info yang penting kepada masyarakat tetapi terkadang tidak betemu dengan masyarakatnya karena sibuk bekeja di sawah. Dan ada juga yang di sediakan info desa, jadwal serta kegiatan di kantor desa. Untuk masyarakat mendapatkan informasi desa, kegiatan, jadwal dan berita desa harus datang ke kantor desa setempat. Informasi yang mereka dapatkan terlihat dari papan pengumuman di kantor desa. Jika tidak ada informasi yang tersedia, masyarakat akan kembali ke rumah. Sehingga membuang waktu dan mendapatkan informasi menjadi tidak pasti. Dengan melihat hasil penelitian kendala yang ada. Peneliti bertujuan mengimplementasikan e-desa sebagai wadah meningkatkan kualitas pelayanan bagi masyarakat Desa Teluk buyung dan mempermudah perangkat desa dalam memberikan serta mengelola informasi. Manfaat bagi masyarakat untuk dengan mudah mendapatkan informasi dan serta pelayanan yang cepat tanpa terhalang oleh ruang dan waktu serta menambah pengetahuan dalam menggunakan teknologi..
Kata Kunci: Implementasi; E-desa; Kualitas; Pelayanan; Masyarakat.
Analisa Data Mining Untuk Prediksi Penyakit Ginjal Kronik Dengan Algoritma Regresi Linier
Authors: Kurniadi Hermawan Angga , Nugroho Agung , Edora  
Published: January 2024

In this study, we evaluate the ability of data mining to predict chronic kidney disease using a linear regression algorithm. We extract features from patient clinical data and apply a linear regression algorithm to build a predictive model. The results showed that our linear regression model was able to predict with high accuracy and could be used as an aid in diagnosing chronic kidney disease. In addition, we also analyze the factors that influence the risk of developing chronic kidney disease and suggest preventive measures that can be taken to reduce the risk of developing the disease. The results of this study can be used by doctors to improve efficiency in diagnosing and preventing chronic kidney disease. In addition, these results can also be used as a basis for further research in the field of data mining and chronic kidney disease. The process of testing the data in this study using a linear regression algorithm is able to provide good results with a Root Mean Squared Error: 0.285 +/- 0.000 and Squared Error: 0.081
+/- 0.234.
Perbandingan Algoritma Extreme Learning Machine dan Multilayer Perceptron Dalam Prediksi Mahasiswa Drop Out
Authors: Saad Muhammad Ibnu Saad 
Published: January 2024

Determined by the university concerned. The high number of drop out students at tertiary institutions can be minimized by policies from tertiary institutions to direct and prevent students from dropping out that detecting at-risk students in the early stages of education is very important to do to keep students from dropping out.
The purpose of this study is to classify and compare the Extreme Learning Machine and Multilater Perceptron algorithms in predicting student drop out. This study uses two algorithms, namely Extreme Learning Machine and Multilater Perceptron which are feedforward artificial neural network learning methods.
The data used is 110 data according to the number of students from class 2012 to 2018. The data is taken from the Doctor of Education Management academic information system. In this case how to predict student drop out using the variables Gender, Working Status, Family Status, Age, Semester 3 GPA, Comprehensive Examination, Dissertation Progress, and Publications. The results of the Extreme Learning Machine classification based on a ratio of 80:20 get an accuracy of 95% with a hidden layer of 20 and a Mean Squared Error value of 0.369. Whereas the Multilater Perceptron with the same ratio gets 91% accuracy. From the two models used, it shows that the two artificial neural network algorithms can produce good performance in predicting drop out students.
Implementasi Sistem Pendukung Keputusan dalam menentukan Kecamatan Terbaik Menggunakan Algoritma Entropy dan Additive Ratio Assessment (ARAS)
Authors: Ernawati Andi , Ofta Sari Ayu , Sofyan Siti Nurhaliza , Aulia Ananda , Sitorus Zulham , Khairul  
Published: January 2024

In the context of regional development and decision making related to determining the best village, the use of a Decision Support System (DSS) with the application of the Entropy and Additive Ratio Assessment (ARAS) algorithms is a very important approach. The main objective of this research is to propose and implement a method that utilizes the Entropy algorithm to evaluate criteria weights and ARAS to rank villages based on predetermined criteria. This approach begins the process by identifying relevant criteria to determine the best village in an area. Next, the Entropy algorithm is used to measure the level of importance or relative weight of each predetermined criterion. This step helps in assessing how informative each criterion is in the decision-making process regarding determining the best Village.
After determining the criteria weights using Entropy, the approach continues with the application of the ARAS method. ARAS is used to rank villages based on normalized values ​​from previously determined criteria. The data normalization process is carried out to ensure the validity of comparisons between villages. The final result of this approach is a ranking of villages indicating the best villages based on the criteria considered. This method was tested in a case study using a dataset involving a number of relevant criteria for assessing village development potential. Experimental results show that the use of the Entropy and ARAS algorithms in the Decision Support System provides an effective and informative framework for decision makers in determining the best Village. In conclusion, this approach provides a solid foundation to support a more effective and precise decision-making process in regional development based on clearly defined criteria.
Analisis IT Service Management Layanan GrabFood Menggunakan Framework ITIL V3 Pada PT Grab Teknologi Indonesia
Authors: Arjun Jennifer , Sutabri Tata 
Published: January 2024

Teknologi informasi yang sangat berkembang terutama pada sektor perdagangan dalam bidang kuliner. Penggunaan teknologi dalam bidang kuliner membuat layanan GrabFood menjadi popular dikarenakan cepat, mudah dan praktis. Layanan GrabFood memberikan layanan dimana pengguna dapat memesan makanan dari restoran yang bekerjsama dengan GrabFood, serta terdapat promo yang menarik bagi para pengguna. Layanan ini memungkinkan untuk pengguna dapat memesan makanan apapun walaupun jauh dari pengguna. Layanan ini juga menguntungkan bagi pemilik bisnis pada bidang kuliner karena dapat menambahkan pemasukan serta memperluas jangkauan pembeli dengan menggunakan GrabFood maka bisnis menjadi lebih cepat dan mudah. Penelitian ini menggunakan pengumpulan data melalui kuesioner dan mendapatkan 56 responden. Lalu akan dilakukan perhitungan maturity level atau tingkat kematangan untuk menganalisis apakah layanan GrabFood sudah cukup baik dalam melakukan service operation di masyarakat. Pada penelitian ini peneliti menggunakan framework ITIL V3 untuk menganalisis layanan GrabFood terutama pada Service Operation, yang terdiri dari 5 subdomain yang mendapatkan nilai maturity level sebesar 4.03 untuk subdomain Event Management, nilai maturity level sebesar 3.94 untuk subdomain Incident Management, nilai maturity level sebesar 4.01 untuk subdomain Problem Management, lalu nilai maturity level sebesar 4.02 untuk subdomain Request Fulfillment dan, nilai maturity level sebesar 4.10 untuk subdomain Access Management. Maka dapat dinyatakan semua subdomain berada pada Level 4 yaitu Managed.
Evaluasi User Engagement dan User Experience pada Aplikasi Satu Sehat
Authors: Halim Fandi , Suwandy Riche 
Published: January 2024

Various efforts to prevent and trace the wider spread of the Covid-19 Virus have been carried out by the government. One of them is done with through technology by providing the application namely SatuSehat application which has variety of features aimed on helping the society. However, along with the imminent evolution of this application into SatuSehat application, these various features that exist, are still rarely known by the public. In addition, from previous studies, there are user experience evaluation has been carried out which shows that low evaluation results. Even though this application has been widely downloaded by the public. This study is aimed at re-measuring the user experience of SatuSehat application and is accompanied by user engagement evaluation to SatuSehat application and its relationship with the user experience. User experience evaluation will utilize the UEQ-S method while the user engagement evaluation will utilize the UEQ-SF method. The results showed that SatuSehat application has a positive overall user experience evaluation result which is supported by quite good user engagement evaluation results. The results of the study even show that there is a strong correlation between user engagement and user experience from the SatuSehat application.