bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparing for implementation of long-acting injectable cabotegravir for HIV pre-exposure prophylaxis within the Brazilian public health system: The ImPrEP CAB Brasil Study
Authors: Pimenta Cristina , Torres Thiago Silva , Cohen Mirian , Hoagland Brenda , Mann Claudio Gruber , Jalil Cristina , Carvalheira Eduardo , Freitas Lucilene , Fernandes Nilo , Castanheira Debora , Benedetti Marcos , Moreira Julio , Simpson Keila , Trefiglio Roberta , O’Malley Gabrielle , Veloso Valdilea G , Grinsztejn Beatriz , Team ImPrEP ImPrEP CAB Brasil Study 
Published: November 2023

Abstract
Introduction
Although long-acting injectable cabotegravir (CAB-LA) PrEP has proven efficacious for HIV prevention in clinical trials, additional research is needed to guide effective implementation in real world settings.
Methods
ImPrEP CAB-Brasil is an implementation study of same-day delivery of CAB-LA PrEP for young sexual and gender minorities (SGM; aged 18-30 years) in six existing oral PrEP public health clinics. We conducted formative research to prepare for the implementation of ImPrEP CAB-Brasil through (1) community mobilization; (2) process mapping; and (3) focus group discussions with young SGM (N=92) and health professionals (N=20) to identify facilitators and barriers to injectable PrEP implementation and request feedback on an mHealth education and decision support tool and WhatsApp appointment reminder intervention.
Results
Community mobilization team collaborated in developing prototype materials for an mHealth intervention to support PrEP-user decision making, participated in study protocol training sessions, and contributed to the planning of peer education activities. We created three process maps for each site to describe the initial visit, follow-up visits and laboratory flow. The main challenge identified for same-day CAB-LA PrEP delivery was the duration of clinic visits due to a high number of laboratory and HIV counseling steps necessary. Proposed solutions included point-of-care HIV rapid tests (with additional training) instead of laboratory tests and the addition of more staff to perform counseling. Identified barriers for CAB-LA PrEP implementation included the training of health professionals, creating a stigma-free environment, and ensuring adherence to injection appointments. The mHealth educational video and WhatsApp messages showed high acceptability by both SGM and health providers. Content analysis on appropriateness of language and for overall clarity of the material contributed to the refinement of the mHealth component.
Conclusions
Structured formative work with SGM community members and health providers generated important refinements to context-specific materials and plans for the launch of ImPrEP CAB-Brasil in public health clinics. Continuous monitoring of the implementation of mapped processes will help further identify barriers and solutions to CAB-LA PrEP delivery. Summative evaluations are needed to measure the effectiveness of the mHealth educational video and WhatsApp appointment reminders.
Trial Registration
ClinicalTrials.gov NCT05515770 (29-AUG-2022)
Investigation of the Mineralogical Composition and Origin Analysis of Black Jadeite
Authors: Guo Fenghui , Xu Wei , Tang Minghui , Zhang Ziqi , Chen Zean 
Published: November 2023

Abstract
Analyzing black jadeite variety not only helps to distinguish it from the more common omphacite jadeite, but also helps to study the origin of jadeite by studying these special specimens. The basic gemological properties, mineral composition, structural characteristics, spectroscopic features, and color-causing mechanisms of black jadeite were studied through testing methods such as Polarizing microscope, X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy. Research has shown that black Jadeite have columnar crystalloblastic texture, granular crystalloblastic texture, fibrous crystalloblastic texture, and fracture structures. The secondary minerals are black impurities, manifested as opaque irregular small dots, and their Raman spectra and X-ray diffraction show typical characteristics of a mixture of graphite and disordered graphite. Based on the distribution of graphite and disordered graphite mixtures, they exhibit varying degrees of light absorption, resulting in the formation of different shades of black, which is the color-causing factor of black jadeite. These carbonaceous substances are the result of the carbonization of mixed organic matter in the fluid during the metamorphic process, gradually forming dispersed graphite and disordered graphite, distributed in mineral crystals, the interstices between mineral crystals, mineral crystal fracture surfaces, and cataclastic texture, indicating a multi-stage metamorphic cause. The discovery of graphite in jadeite supports the hypothesis that jadeite protolith originated from the subduction process of the Neotethys Ocean, accompanied by the metasomatism and high-pressure metamorphism of olivinite.
Extrapolation methods for multilinear PageRank
Authors: Bentbib Abdeslem Hafid , Boubekraoui Maryam , Jbilou Khalide 
Published: November 2023

Abstract
Multilinear PageRank is a variant of the PageRank algorithm that takes into account multiple relationships among nodes in a network. This algorithm can make web page ranking more efficient and accurate by considering multiple types of connections at once. The higher-order power method is commonly used to calculate the multilinear PageRank vector due to its ease of implementation, low storage needs, and because it is a natural extension of the traditional power method used in the PageRank algorithm. However, the convergence of this method is not always guaranteed, and even if it is, it is slow. In this paper, we show how some vector extrapolation methods such as minimal polynomial extrapolation (MPE) and reduced rank extrapolation (RRE), could be used for accelerating the computation of the fixed-point multilinear PageRank.
Next-Generation Histopathology: A Clinical Trial of Advanced Virtual Histochemical Stains
Authors: Turan Mehmet , Kinali Fatma Nur , Demir Derya , Ozyoruk Kutsev , Almalioglu Yasin , Kose Emre , Williamson Drew , Serin Gurdeniz , Keles G. Evren , Kumbaraci Banu Sarsik , Utku Ceren , Hacısalihoglu Uguray , Turkmen Ilknur , Ozturk Figen , Ertas Yavuz , Kurt Ibrahim , Basak Kayhan 
Published: November 2023

Abstract
Histopathological analysis traditionally relies on Hematoxylin and eosin (H&E) staining. However, comprehensive differential diagnoses often require additional histochemical stains, leading to increased diagnostic time and costs. To address these limitations, we introduce AI-XStainer, a novel virtual staining tool powered by advanced deep learning techniques. This system adeptly transforms conventional H\&E-stained images into multiple histochemical visualizations, marking a significant advancement in diagnostic histopathology. To validate AI-XStainer's efficacy, we conducted a rigorous clinical trial involving seasoned nephropathologists. Using the OmniST dataset—a carefully curated collection of 1646 whole slide images (WSIs) representing diverse patient samples, including renal transplant, liver explants, non-malignant renal disease, and Helicobacter pylori gastritis and paired with standard stains such as Masson’s trichrome (MT), Periodic acid-Schiff (PAS), Jones methenamine silver (JMS), and Toluidine blue (TB)—our tool underwent intensive clinical evaluation. The results were precise: our virtually stained slides enabled board-certified experienced nephropathologists (>10) to achieve diagnostic accuracy on par with, if not superior to, traditional staining techniques. AI-XStainer consistently outperformed various assessment benchmarks, including patch-level and slide-level visual Turing Tests, and showed favorable performance in the Frechet Inception Distance comparison, further underscoring its transformative potential. In summary, AI-XStainer emerges as a promising and paradigm-shifting solution for expeditious and precise histopathological diagnosis with significant potential clinical impact.
Controlling changes caused by holes by adding fibers to composite concrete components
Authors: Fathi Hamoon 
Published: November 2023

Abstract
Crack propagation can be affected by the holes of the placement of rebars in the reinforced concrete and the resulting changes in the homogeneous structure of concrete. This experimental study aimed at investigating the fiber self-compacting concrete failure and crack propagation in concrete specimens with circular central holes and fiber with the radius of 2, 4, and 8 percent. The crack propagation mechanisms under the uniaxial compressive strength of the concrete were studied by investigating the holes created by rebars buried in the reinforced concrete. Three concrete mix designs with different compressive strengths of 27, 30, and 33 were used for detailed analysis of the fiber concrete behavior by 224 cubic specimens. The results showed the insignificant impact of small holes with an approximate area of 1.4% of the specimen surface area on the failure structure so that crack propagation in this case was similar to that occurred in the hole-free concrete. The compressive strength of concrete decreased, by increasing the crack prorogation around the holes. The compressive strength of the concrete may be reduced significantly by increasing the hole diameter. Taking into account these factors in the design of the connection core can reduce the compressive strength of concrete by 30% depending on the rebar grid.
Pilonidal Disease Treatment with Silver Nitrate
Authors: Kılcı Mahmut Burak , Dalda Yasin , Şahin Emrah , Kayaalp Cüneyt 
Published: November 2023

Abstract
Objective
Minimal invasive treatment approaches for pilonidal disease have been described as controlled tissue damage of the sinus cavity via chemical agents or lasers. Although silver is a widely used chemical for healing wounds, there are limited studies about pilonidal disease management. The aim of this study is to evaluate the efficacy of silver nitrate on pilonidal disease.
Patients and Methods
Patients who were diagnosed with pilonidal disease were treated with silver nitrate application. Silver Nitrate was applied in the sinus tract following the excision of the sinus orifice with a small incision and debriding the sinus cavity. Silver Nitrate sticks were used to obtain controlled damage in the tissue of the sinus cavity for three sessions on the 0, 1st, and 7th days.
Results
Forty-two patients with pilonidal disease were included in this study and silver nitrat treatment was applied in our institute. The median age of the patients was 24 (16-56), and all of the treatment procedures were applied in the operation room. Tirthy one of the patients (%73,8) was accepted as treated at the end of the 12-month follow-up duration.
Conclusions
Silver Nitrate treatment is a simple, safe, and cheap minimally invasive treatment technique for pilonidal disease. This treatment can be performed in outpatient clinics, and the results of this study were comparable with other minimally invasive techniques.
Negative body image induces depression among adolescents in China: a mediation model
Authors: Yuan Ye , Chen Naiche , Chen Daile , Zhou Qiang , Jeong Jaesik , Jiang Ke 
Published: November 2023

Abstract
Objective: To explore the pathways through which negative body image affects depression in college students and possible means of achieving depression interventions in college populations through the mediating roles of self-efficacy and physical activity, and the moderating role of social support.
Methods: The study used a convenience random sampling method to collect data from 600 university students using the Body Image Scale, Self-Efficacy Scale, Physical Activity Scale, General Social Support Scale, and Depression Self-Rating Scale; data analysis as well as Structural Equation Modeling was performed using SPSS and M-plus as well as R software.
Results: Body image negatively predicted depression, Body image and physical exercise play a chain mediating role between body image and depression, also social support moderated self-efficacy in predicting the pathway of physical activity effects, as well as physical activity in predicting the pathway of depression effects.
Conclusion: The study found that college students' dissatisfaction with their physical appearance may induce depression; physical activity can change the association from body image to depression, in which self-efficacy is an important mediator; and social support moderates adherence to exercise, thus providing an intervention for depression.
A complete chloroplast and mitochondrial genome for velvet bean (Mucuna pruriens, Fabaceae), with genome structure and intergenomic sequence transfers analyses
Authors: Satrio Rizky Dwi , Nikmah Isna Arofatun , Fendiyanto Miftahul Huda , Pratami Mentari Putri , Dewi Asih Perwita , Hariri Muhammad Rifqi , Hastilestari Bernadetta Rina , Yul Kusumadewi Sri , Miftahudin M 
Published: November 2023

Abstract
Mucuna pruriens, commonly known as the velvet bean, holds considerable economic and cultural importance as a member of the Fabaceae family. The economic value of this plant is derived from its high protein content, medicinal properties, and potential applications in agriculture and industry. Although the entire nuclear genome consisting of 11 chromosomes of M. pruriens has been published, the comprehensive assembly of the organelle genome, specifically the mitochondria, has not been previously accomplished. The evaluation of sequence transfer from both the chloroplast and mitochondrial genomes to the nuclear genome has not been conducted. The complete chloroplast and mitochondrial genome of M. pruriens var. utilis was assembled and annotated through the utilization of a hybrid approach involving Illumina short-reads and Oxford Nanopore long-reads. The genome of chloroplasts was found to be arranged in a singular circular structure measuring 155,617 bp in length. This structure encompassed a total of 75 genes responsible for encoding proteins, along with 4 genes for ribosomal RNA and 28 genes for transfer RNA. The organization of the mitochondrial genome consisted of a singular circular structure measuring 410,745 bp in length, encompassing a total of 39 protein-coding genes, 4 ribosomal RNA genes, and 16 transfer RNA genes. Through the analysis of sequence transfer, it has been determined that a total of 154,498 bp and 158,285 bp of DNA, derived from the chloroplast and mitochondrial genome respectively, have been incorporated into the nuclear genome. These transfer events predominantly occurred in a relatively recent timeframe. The frequency of transfers of chloroplast to nuclear genome sequences was found to be similar to that of transfers of mitochondrial to nuclear genome sequences. This study presents the initial assembly of the entire organelle, specifically the mitochondrial genome of M. pruriens, which serves as a valuable tool for comprehending the genomic evolution within the diverse Fabaceae family.
Exploring the Mechanism of Epimedium on Osteonecrosis of the Femoral Head through Network Pharmacology
Authors: Qi Yuxin , Hu Wei , Meng Chenyang , Jiang Enze , Ge Zhe , Wang Pei , Wang Jianzhong 
Published: November 2023

Abstract
BACKGROUND
Traditional Chinese Medicine (TCM) has consistently demonstrated promise in the prevention and management of ONFH. Epimedium, historically revered in Chinese medicinal recipes, has been utilized for mitigating conditions such as osteonecrosis and symptoms of kidney yang deficiency.
OBJECTIVE
This study aimed to forecast the drug targets and associated pathways through which Epimedium exerts its therapeutic effects against osteonecrosis of the femoral head. Additionally, we sought to delve deeper into its mechanism at the molecular level.
METHODS
In this study, we identified the active constituents and targets of Epimedium using the TCMSP database. The GEO database (with accession number GSE123568) was consulted to pinpoint targets associated with SONFH. Differential gene expression was visually represented through volcano and heat maps, crafted using the R software. GO and KEGG analyzes of these target genes were also subsequently performed using R software.
RESULTS
Five pivotal target genes were identified: PTGS2, KCNH2, BCL2L1, ABCG2, and E2F2. An exhaustive topological analysis was performed encompassing eight pathways and three genes.
CONCLUSION
This study elucidates the fundamental constituents, specific targets, and molecular pathways that underlie the effectiveness of Epimedium in the treatment of osteonecrosis of the femoral head.
A nomogram for predicting 28-day mortality in elderly patients with acute kidney injury receiving continuous renal replacement therapy: a secondary analysis based on a retrospective cohort study
Authors: Li Xiang , Li Yang , Fan Cheng-Juan , Jiao Zhan-feng , Zhang Yi-Ming , Luo Na-na , Ma Xiao-Fen 
Published: November 2023

Abstract

Background
Acute kidney injury (AKI) is a common and serious condition, particularly among elderly patients. It is associated with high morbidity and mortality rates, further compounded by the need for continuous renal replacement therapy (CRRT) in severe cases. To improve clinical decision-making and patient management, there is a need for accurate prediction models that can identify patients at a high risk of mortality.
Methods
Data were extracted from the Dryad Digital Repository. Multivariate analysis was performed using least absolute shrinkage and selection operator (LASSO) logistic regression analysis to identify independent risk factors and construct a predictive nomogram for mortality within 28 days after CRRT in elderly patients with acute kidney injury. The discrimination of the model was evaluated in the validation cohort using the area under the receiver operating characteristic curve (AUC), and calibration was evaluated using a calibration curve. The clinical utility of the model was assessed using decision curve analysis (DCA).
Results
A total of 606 participants were enrolled and randomly divided into two groups: a training cohort (n = 424) and a validation cohort (n = 182) in a 7:3 proportion. The predictors included age, systolic blood pressure, creatinine, albumin, phosphorus, age-adjusted Charlson comorbidity index (CCI), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and sequential organ failure assessment (SOFA) score. These predictors were incorporated into a logistic model and presented in a user-friendly nomogram. In the validation cohort, the model demonstrated good predictive performance with an AUC of 0.799. The calibration curve showed that the model was well calibrated. Additionally, DCA revealed significant net benefits of the nomogram for clinical application.
Conclusion
The development of a nomogram for predicting 28-day mortality in elderly patients with AKI receiving CRRT has the potential to improve prognostic accuracy and assist in clinical decision-making.
Thermally exfoliated graphitic carbon nitride (g-C 3 N 4 )-based photocatalysts for the effective degradation of abundant textile dyes
Authors: Ganesan Selvaganapathy , Kokulnathan Thangavelu , Sumathi Shanmugam , Palaniappan Arunkumar 
Published: November 2023

Abstract
Graphitic carbon nitride (g-C3N4), an organic semiconductor-based photocatalyst was reported to have several beneficial properties to be used in wastewater treatment applications. However, g-C3N4, in its bulk form has poor photocatalytic degradation efficiency due to its inherent limitations such as poor specific surface area and fast electron-hole pair recombination rate. In this study, we have tuned the physiochemical properties of bulk g-C3N4 by direct thermal exfoliation and examined their photocatalytic degradation efficiency against abundant textile dyes such as methylene blue (MB), methyl orange (MO), and rhodamine B (RhB). The degradation efficiencies for MB, MO, and RhB dyes are 92 ± 0.18%, 93 ± 0.31%, and 95 ± 0.4% respectively in 60 min of UV light irradiation. The degradation efficiency increases with an increase in the exfoliation temperature. The prepared catalysts were characterized using FTIR, XRD, FE-SEM, EDAX, BET, and UV-DRS, to confirm their material structure, phase, surface morphology, elemental composition, specific surface area and optical properties respectively. Further, adsorption efficiency and reusability were also tested. The findings derived from the scavenging studies revealed that the involvement of superoxide radicals was the most crucial in the process of photodegradation for all dyes. PL emission and EIS spectra of exfoliated g-C3N4 indicated a decrease in the recombination rate of electron-hole pairs created by photoexcitation and enhancement in the efficiency of photo-induced charge transfer. Further, the exfoliated g-C3N4 photocatalysts were found to have excellent stability for up to 5 cycles with a minor decrease in the activity. These findings proved that exfoliated g-C3N4can be an excellent photocatalyst for the removal and degradation of textile dyes from wastewater.
Depth grid based local description for 3D point clouds
Authors: Sa Jiming , Zhang Xuecheng , Zhang Chi , Song Yuyan , Ding Liwei , Huang Yechen 
Published: November 2023

Abstract
With the rapid development and extensive application of next-generation image processing technologies, the manufacturing industry is increasingly adopting intelligent equipment. In order to meet the demands of high precision and high efficiency production, there has been a growing focus on researching 3D point cloud processing methods that go beyond traditional approaches. A fundamental and crucial challenge in the field of point cloud processing is establishing a point-to-point correspondence mapping between two point clouds, which relies on leveraging the local feature description information inherent in the point cloud.This paper thoroughly investigates novel local description methods based on point cloud processing. It addresses the issue of inadequate descriptive capability and robustness found in existing local description methods. Specifically, this study explores the encoding of point information in the neighborhood space and multi-view projection mapping, proposing a local point cloud description method based on depth grids. This method leverages a local reference frame and establishes a depth grid after obtaining the local reference frame through neighborhood projection and distance weighting. The contribution of neighboring points to the depth of the grid is calculated to obtain the eigenvalues. To enhance efficiency, the calculation of eigenvalues incorporates normalization and multi-view projection techniques. The proposed method is compared and evaluated against various local description methods to verify its effectiveness and accuracy.
Effectiveness of tranexamic acid for improving visual clarity by reducing total coagulation time during arthroscopic rotator cuff repair
Authors: Lim Joon-Ryul , Do Woo-Sung , Chang Hsien-Hao , Yoon Tae-Hwan , Chun Yong-Min 
Published: November 2023

Abstract
This study aimed to investigate the reliability of electrocautery sound spectrogram visualization and to examine the effectiveness of tranexamic acid during arthroscopic rotator cuff repair in terms of coagulation and operation time. We included 132 patients who underwent arthroscopic rotator cuff repair using the double-row suture bridge for medium-sized full-thickness rotator cuff tear with 1g IV tranexamic acid or without tranexamic acid. During surgery, the sound of the electrocautery device was recorded, and the total coagulation time was analyzed using a spectrogram. The primary outcome was total coagulation time. The total coagulation time was significantly reduced in the study group compared to the control group. Spectrographic analysis of sounds produced by electrocautery devices is reliable for measuring coagulation time during arthroscopic surgery. Use of tranexamic acid may provide better visual clarity during arthroscopic cuff repair by reducing coagulation time with an electrocautery device.