bluuebunny/crossref_metadata_2025_split huggingface dataset:
C‐X‐C chemokine receptor type 4 promotes tubular cell senescence and renal fibrosis through β‐catenin‐inhibited fatty acid oxidation
Authors: Wu Qinyu , Chen Qiurong , Xu Dan , Wang Xiaoxu , Ye Huiyun , Li Xiaolong , Xiong Yabing , Li Jiemei , Zhou Shan , Miao Jinhua , Shen Weiwei , Liu Youhua , Niu Hongxin , Tang Ying , Zhou Lili 
Published: January 2024

AbstractThe prevalence of chronic kidney disease (CKD) is highly increasing. Renal fibrosis is a common pathological feature in various CKD. Previous studies showed tubular cell senescence is highly involved in the pathogenesis of renal fibrosis. However, the inducers of tubular senescence and the underlying mechanisms have not been fully investigated. C‐X‐C motif chemokine receptor 4 (CXCR4), a G‐protein‐coupled seven‐span transmembrane receptor, increases renal fibrosis and plays an important role in tubular cell injury. Whereas, whether CXCR4 could induce tubular cell senescence and the detailed mechanisms have not studied yet. In this study, we adopted adriamycin nephropathy and 5/6 nephrectomy models, and cultured tubular cell line. Overexpression or knockdown of CXCR4 was obtained by injection of related plasmids. We identified CXCR4 increased in injury tubular cells. CXCR4 was expressed predominantly in renal tubular epithelial cells and co‐localized with adipose differentiation‐related protein (ADRP) as well as the senescence‐related protein P16INK4A. Furthermore, we found overexpression of CXCR4 greatly induced the activation of β‐catenin, while knockdown of CXCR4 inhibited it. We also found that CXCR4 inhibited fatty acid oxidation and triggered lipid deposition in tubular cells. To inhibit β‐catenin by ICG‐001, an inhibitor of β‐catenin, could significantly block CXCR4‐suppressed fatty acid oxidation. Taken together, our results indicate that CXCR4 is a key mediator in tubular cell senescence and renal fibrosis. CXCR4 promotes tubular cell senescence and renal fibrosis by inducing β‐catenin and inhibiting fatty acid metabolism. Our findings provide a new theory for tubular cell injury in renal fibrosis.
EEBR induces Caspase‐1‐dependent pyroptosis through the NF‐κB/NLRP3 signalling cascade in non‐small cell lung cancer
Authors: Zhao Xin , Chen Chao , Han Weina , Liang Min , Cheng Yuanyuan , Chen Yingjie , Pang Defeng , Lei Haoqi , Feng Xuefei , Cao Shifeng , Li Zhixiong , Wang Jinhui , Zhang Yan , Yang Baofeng 
Published: January 2024

AbstractLung cancer is a leading cause of cancer‐related deaths worldwide. Recent studies have identified pyroptosis, a type of programmed cell death, as a critical process in the development and progression of lung cancer. In this study, we investigated the effect of EEBR, a new compound synthesized by our team, on pyroptosis in non‐small cell lung cancer cells (NSCLC) and the underlying molecular mechanisms. Our results demonstrated that EEBR significantly reduced the proliferation and metastasis of NSCLC cells in vitro. Moreover, EEBR‐induced pyroptosis in NSCLC cells, as evidenced by cell membrane rupture, the release of cytokines such as interleukin‐18 and interleukin‐1 beta and the promotion of Gasdermin D cleavage in a Caspase‐1‐dependent manner. Furthermore, EEBR promoted the nuclear translocation of NF‐κB and upregulated the protein level of NLRP3. Subsequent studies revealed that EEBR‐induced pyroptosis was suppressed by the inhibition of NF‐κB. Finally, EEBR effectively suppressed the growth of lung cancer xenograft tumours by promoting NSCLC pyroptosis in animal models. Taken together, our findings suggest that EEBR induces Caspase‐1‐dependent pyroptosis through the NF‐κB/NLRP3 signalling cascade in NSCLC, highlighting its potential as a candidate drug for NSCLC treatment.
Core outcome sets for myocardial infarction in clinical trials of traditional Chinese medicine and Western medicine
Authors: Qiu Ruijin , Wan Siqi , Zhong Changming , Han Songjie , He Tianmai , Huang Ya , Wei Xuxu , Li Meng , Guan Zhiyue , Zhang Xinyi , Wu Huanlin , Shang Hongcai 
Published: January 2024

AbstractBackgroundClinical trials of traditional Chinese medicine (TCM) and Western medicine showed there was heterogeneity of outcome reporting in myocardial infarction (MI). Developing a core outcome set (COS) might improve the consistency of outcome reporting in future clinical trials.MethodsA list of outcomes was developed based on a systematic review of randomized controlled trials (RCTs) of MI and semistructured interviews with MI patients. Two rounds of Delphi survey for clinicians, researchers, journal editors, and methodologists were conducted. An online questionnaire sent to nurses. After an online consensus meeting, a COS for MI RCTs was developed.ResultsAfter extracted data from clinical trials and discussed, 216 outcomes were included in round 1 of the Delphi survey. Seventy‐four participants completed round 1 of the Delphi survey. Sixty‐five participants completed round 2 of the Delphi survey. Twenty‐two nurses completed the online questionnaire. Fifteen participants attended the online consensus meeting, and 14 of them voted and determined the final COS. For all types of MI, it was recommended that left ventricular ejection fraction and quality of life be measured and reported. For acute MI, the participants in the consensus meeting recommended the following core outcomes: death from cardio‐cerebrovascular disease, cardiogenic shock, heart failure, troponin I, troponin T, creatine kinase isoenzyme, Killip class, target vessel revascularization, and emergency CABG. For previous MI, recurrent MI, recurrent angina pectoris, and heart failure readmission were recommended.ConclusionsThe COS for MI in RCTs provides recommendations for clinical trials that seek to improve outcomes for patients with MI.
Biological and productive aspects of the black soldier fly Hermetia illucens (Diptera: Stratiomyidae) in meal moth rearing residues Ephestia kuehniella (Lepidoptera: Pyralidae)
Authors: Zanotelli Alex Lima , Köhler Andreas 
Published: January 2024

AbstractThe inadequate disposal of organic waste generated in insect biofactories breeding biological agents may become a potential environmental problem. The use of Hermetia illucens (Diptera: Stratiomyidae) may play an important role in the circular economy of this process, transforming waste into high‐quality biomass. Therefore, this work aims to analyse the degradation of organic residues of Ephestia kuehniella (Lepidoptera: Pyralidae) production using the black soldier fly. Four types of waste from the moth breeding process were evaluated: residues of the meal diet when moth larvae were in the last instar; residues of the meal diet when completing the cycle; residues formed by webs in the pupation process mixed with residual exoskeleton, and residues of dead adults. These residues were tested in isolation and in mixtures of 50%, using as control a standard diet composed of chicken feed. Survival rate, development time, emerged adults, weight, size, residue reduction, and bioconversion were evaluated. The residue used in diets affected the total development time of H. illucens. The mean number of survivors differed from 87% to 74% for larvae that reached the pre‐pupal stage. The viability of pre‐pupae to adult stage ranged from 54% to 6% for residue treatments and 97% for the control. Differences in the growth and weight gain of larvae were significantly different. The rate of residue reduction from 54% to 80% and bioconversion into larval biomass were satisfactory. However, regarding adult emergence, the numbers show variations, indicating that certain residues are not suitable for the maintenance of fly breeding.
Subjective sleep onset latency is influenced by sleep structure and body heat loss in human subjects
Authors: Iijima Ryusei , Kadooka Akari , Sugawara Kairi , Fushimi Momo , Hosoe Mizuki , Aritake‐Okada Sayaka 
Published: January 2024

SummaryThe present study examined the relationship between subjective sleep onset latency (SOL), sleep structure, changes in skin and body temperature, and subjective evaluation of sleep in healthy young adults to elucidate the pathophysiological mechanisms of insomnia. A total of 28 participants (age 21.54 [0.50] years) with no sleep problems participated in a 1‐h polysomnographic recording that obtained objective sleep parameters during the daytime while skin and body temperatures were recorded. The distal–proximal skin temperature gradient (DPG) was calculated. Subjective parameters, such as subjective SOL, sleep time, and restorative sleepiness, were evaluated before and after sleep. Most participants estimated their sleep latency as being longer than their actual SOL (13.7 versus 7.6 min). Objective SOL was significantly correlated with each sleep stage parameter whereas subjective SOL was negatively correlated with Stage N2 sleep duration (Rho = −0.454, p = 0.020), slow‐wave activity and delta power (Rho = −0.500, p = 0.011 and Rho = −0.432, p = 0.031, respectively), and ΔDPG (the degree of reduction of heat loss before and after lights‐off). Stepwise regression analysis showed that ΔDPG was the strongest predictive factor in explaining the length of subjective SOL. The degree of heat dissipation before and after lights‐off contributed most to the sensation of falling asleep in healthy young adults. This finding may be helpful for elucidating the physiological mechanisms of insomnia and its treatment.
Placement of peripherally inserted central catheters in neonates: A retrospective study
Authors: Chen Xiuwen , Lin Chiayen , Yue Liqing , Tan Yanjuan 
Published: January 2024

AbstractBackgroundPeripherally inserted central catheters (PICCs) are commonly used in neonatal intensive care units for extended intravenous nutrition and therapy. The selection of PICCs insertion sites can significantly influence insertion outcomes and neonatal safety.AimThis study aimed to determine the most suitable insertion site in the lower extremities for neonatal PICCs.Study DesignA retrospective case note review was conducted on PICCs inserted through lower extremity (LE) sites in a 40‐bed tertiary‐level neonatal intensive care unit at a university teaching hospital. The dates when data were accessed for research purposes were from June 2019 to June 2022. In total, 223 neonates were identified as having had PICCs, with 254 catheters inserted in the lower extremities. The STROBE checklist guided the reporting of this study.ResultsNeonates underwent PICC insertion via the LE vein, with an overall complication rate of 13.4% and a one‐attempt success rate of puncture of 86.2%. The rates of complications, catheter occlusion, and catheter‐related infection in the PICC group with insertion through the great saphenous vein were significantly lower than those in the femoral vein group (p < .05). The success rate was significantly higher than that in the femoral vein group (p < .05). Additionally, the incidence of total complications and catheter occlusion complications with PICC insertion via the right LE was significantly lower than that with insertion via the left LE (p < .05).ConclusionOur study suggested that, when feasible, the saphenous vein in the right LE could be the most suitable insertion site for neonatal PICCs.Relevance to Clinical PracticeThese findings provide insights into the complications, indwelling time, and safety of neonatal PICCs in different LE sites, serving as a valuable reference for clinical practice. This study was retrospective in nature, and all staff involved obtained approved access to patient clinical data. Ethical approval was granted by the Ethics Committee of Xiangya Hospital, Central South University (registry number 2022010001).
How does gestational weight gain influence short‐ and long‐term postpartum weight retention? An updated systematic review and meta‐analysis
Authors: Meyer Dorothy , Gjika Ejona , Raab Roxana , Michel Sophie K. F. , Hauner Hans 
Published: January 2024

SummaryThis systematic review and meta‐analysis provide an update of an earlier meta‐analysis examining the impact of gestational weight gain (GWG) on postpartum weight retention (PPWR). Thirty‐four observational studies were included, and results from 18 studies were combined in meta‐analyses. We found that women with excessive GWG retained an additional 2.98 kg (95% CI: 0.59, 5.37 kg, I2 = 91%) at 0.5 years, 1.89 kg (95% CI: 0.90, 2.88 kg, I2 = 61%) at > 0.5–1 year and 2.89 kg (95% CI: 1.74, 4.04 kg, I 2 = 0%) at 2–4 years, compared to women who met the National Academy of Medicine GWG recommendations. Moreover, synthesis of confounder‐adjusted regression coefficients showed that each 1 kg increase of GWG corresponded to 0.62 kg (95% CI: 0.22, 1.02 kg, I2 = 96%) additional PPWR at 6–9 months, 0.48 kg (95% CI: 0.14, 0.81 kg, I2 = 93%) at 1–3 years, and 0.31 kg (95% CI: −0.24, 0.86 kg, I2 = 89%) at 5–7 years postpartum. Findings suggest that higher GWG contributes to increased maternal body weight in the short‐ and long‐term after childbirth, independent of prepregnancy body mass index. The heterogeneity of reported data and methodological differences across studies complicate the ability to synthesize data and interpret findings.
Early Outcomes of Bone Autografting in the Bilateral Atlantoaxial Joints Applied in Posterior Fusion Surgery
Authors: Wang Xing‐jin , Liu Hao , Wang Bei‐yu , Wu Ting‐kui , He Jun‐bo , Yan Lu , Ding Chen 
Published: January 2024

ObjectiveCable‐dragged reduction and cantilever beam internal fixation can provide promising results in the treatment of atlantoaxial dislocation or instability. However, bilateral atlantoaxial joints bone autografting has not been conducted in this technique. We aim to evaluate the safety and effectiveness of bilateral atlantoaxial joints bone autografting in posterior cable‐dragged reduction and cantilever‐beam internal fixation.MethodsIn this retrospective study, we included 14 patients with a minimum 24‐month follow‐up from December 2019 to September 2020. The granular bone harvested from the iliac crest was packed into the bilateral atlantoaxial joints of 14 patients in posterior cable‐dragged reduction and cantilever‐beam internal fixation. X‐ray imaging and cervical computed tomography (CT) were performed during follow‐up. The time required for bone fusion was recorded. The clinical outcomes were evaluated using the JOA scores, NDI, and VAS scores. Mann–Whitney U test, the chi‐squared test, or the Fisher exact test were used to compare the two groups regarding patient characteristics, clinical outcomes, bone fusion rates, and cervical sagittal alignment.ResultsThe operations were successfully performed in all patients without any intraoperative complications. The mean operation time was (169.64 ± 20.91) minutes, and the intraoperative blood loss was (130.71 ± 33.62) mL. All patients received satisfactory reductions and firm bony fusion at the final follow‐up. The fusion rates were 64.29% in the atlantoaxial joints and 21.43% in post bone graft area at 3 months postoperatively, and a significant difference was observed (p = 0.022). Besides, the cervical sagittal alignment in all patients was well maintained in the last follow‐up compared to preoperatively. Importantly, a complete bony fusion in the atlantoaxial joints was observed in all patients. Moreover, the JOA, NDI, and VAS scores had improved significantly at the last follow‐up.ConclusionBone autografting of the bilateral atlantoaxial joints is a safe and effective technique to increase bone fusion rates, shorten bone fusion time, and reduce complication rates when the cable‐dragged reduction and cantilever beam internal fixation approach is used. Therefore, it is a cost‐effective surgical procedure for treating patients with atlantoaxial dislocation or instability.
Local dispersion of repolarization in the occurrence of ventricular fibrillation in Brugada syndrome: Possibility of phase 2 reentry?
Authors: Nagase Satoshi , Oka Satoshi , Kamakura Tsukasa , Aiba Takeshi , Morita Hiroshi , Kusano Kengo 
Published: January 2024

AbstractTo date, there have been no reports of recording epicardial electrograms at the onset of spontaneous ventricular fibrillation (VF) in patients with Brugada syndrome (BrS). In the case of BrS, unipolar and bipolar electrogram recording on the right ventricular epicardium revealed that dispersion of repolarization with delayed potential was associated with spontaneous occurrence of VF. Phase 2 reentry associated with shortening and dispersion of action potential could have been recorded for the first time in BrS. Epicardial unipolar mapping can guide accurate and appropriate ablation for the elimination of arrhythmia substrate in J wave syndrome.
A transcriptional regulation of ERF15 contributes to ABA‐mediated cold tolerance in tomato
Authors: Hu Chaoyi , Wang Mengqi , Zhu Changan , Wu Shaofang , Li Jiajia , Yu Jingquan , Hu Zhangjian 
Published: January 2024

AbstractCold stress is a major meteorological threat to crop growth and yield. Abscisic acid (ABA) plays important roles in plant cold tolerance by activating the expression of cold‐responsive genes; however, the underlying transcriptional regulatory module remains unknown. Here, we demonstrated that the cold‐ and ABA‐responsive transcription factor ETHYLENE RESPONSE FACTOR 15 (ERF15) positively regulates ABA‐mediated cold tolerance in tomato. Exogenous ABA treatment significantly enhanced cold tolerance in wild‐type tomato plants but failed to rescue erf15 mutants from cold stress. Transcriptome analysis showed that ERF15 was associated with the expression of cold‐responsive transcription factors such as CBF1 and WRKY6. Further RT‐qPCR assays confirmed that the ABA‐induced increased in CBF1 and WRKY6 transcripts was suppressed in erf15 mutants when the plants were subjected to cold treatment. Moreover, yeast one‐hybrid assays, dual‐luciferase assays and electrophoretic mobility shift assays demonstrated that ERF15 activated the transcription of CBF1 and WRKY6 by binding their promoters. Silencing CBF1 or WRKY6 significantly decreased cold tolerance. Overall, our study identified the role of ERF15 in conferring ABA‐mediated cold tolerance in tomato plants by activating CBF1 and WRKY6 expression. This study not only broadens our knowledge of the mechanism of ABA‐mediated cold tolerance in plants but also highlights ERF15 as an ideal target gene for cold‐tolerant crop breeding.
Is caring for oneself relevant to happy relationship functioning? Exploring associations between self‐compassion and romantic relationship satisfaction in actors and partners
Authors: Körner Robert , Tandler Nancy , Petersen Lars‐Eric , Schütz Astrid 
Published: January 2024

AbstractSelf‐compassion means being supportive and kind to oneself when experiencing failure or inadequacies. It is associated with adaptive intrapersonal and relational outcomes for individuals. This evidence was extended by using an Actor‐Partner Interdependence framework. Other‐sex couples (N = 209) completed measures of self‐compassion, relationship‐specific self‐compassion, and relationship satisfaction. Both self‐compassion measures were related to global relationship satisfaction and facets thereof (e.g., sexuality, engagement, trust) for actors. Relationship‐specific self‐compassion was also positively related to the partner's relationship satisfaction (particularly for men). It is suggested that researchers (a) consider the interdependence of the partners when analyzing self‐compassion in relationships and test for partner effects and (b) use fine‐grained and domain‐specific measures to develop a more complete understanding of self‐compassion's associations with criterion variables.
Survey on the current situation for early diagnosis of dementia and contributing factors in Japan
Authors: Kumagai Ryoko , Sonoda Yuma , Kowa Hisatomo 
Published: January 2024

AbstractBackgroundEarly diagnosis of dementia is important for both initiation of non‐pharmacological activities to slow cognitive decline as well as the development of disease‐modifying drugs; however, it appears there may be a tendency for formal diagnosis to be delayed. Since the current status of diagnosis in Japan is unclear, we conducted a survey with family caregivers of patients with dementia using questionnaires and interviews to investigate the factors regarding the dementia diagnosis process in Japan.MethodsWe distributed questionnaires to family caregivers of people with dementia and conducted additional follow‐up interviews with approximately half of them. We calculated odds ratios for the time to diagnosis using logistic regression analysis for each characteristic from the questionnaire data. We also created co‐occurrence networks from the interview data in order to provide qualitative context to the questionnaire data.ResultsWe collected 68 questionnaires and conducted 32 interviews. The median time to diagnosis was 12 months, and logistic regression analysis showed a significant trend toward shorter time to diagnosis in the absence of other caregivers. In addition, there were significant differences in age, relationship with patients and the time from the first visit to the final diagnosis between groups with and without other caregivers.ConclusionsThe results of this study suggest that the presence or absence of other caregivers may affect caregivers' behaviour and the time taken to receive a diagnosis of dementia. These findings indicate it may be beneficial to predict inhibiting factors and change approaches based on caregivers' and patients' background to promote early diagnosis.
Breaking the iron triangle around nuclear safety regulation: The cases of France, Japan, and India
Authors: Andrews‐Speed Philip , Putra Nur Azha 
Published: January 2024

AbstractThe International Atomic Energy Agency asserts that the regulation of the safety of civil nuclear power requires national regulatory agencies to be effectively independent. However, in the early years of national civil nuclear power programs national nuclear industries were dominated by iron triangles or subgovernments of powerful actors with an interest in promoting the industry. The creation of an independent safety regulator requires a radical restructuring of the national governance framework. Windows of opportunity or critical junctures for such reform occur only occasionally. This paper examines the cases of France, Japan, and India to identify the factors that determine the degree of success in attempts to break the power of nuclear iron triangles or subgovernments and create an effectively independent regulator. This analysis shows a serious nuclear accident can create the opportunity to dismantle an iron triangle. The extent and speed with which reforms can be implemented depend greatly on pre‐existing and prevailing conditions. Key determinants include the power structures and attitudes toward nuclear power in elite politics, the degree of engagement of civil society, and pressures from international organizations. Of these, the first, elite politics, appears to be the most important in these three cases.