bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning‐based response spectrum analysis method for building structures
Authors: Kim Taeyong , Kwon Oh‐Sung , Song Junho 
Published: January 2024

AbstractThe response spectrum method has gained widespread acceptance in practical applications owing to its favorable compromise between accuracy and practical efficiency. The method predicts the peak responses of multi‐degree‐of‐freedom (MDOF) systems by combining modal responses. The Square Root of the Sum of Squares (SRSS) and Complete Quadratic Combination (CQC) rules are commonly used for modal combinations. However, it has been widely known that these rules have limitations in accurately predicting responses influenced by higher modes and cross‐modal correlations. To improve the accuracy of the response spectrum analysis method for building structures, this paper proposes a Deep learning‐based modal Combination (DC) rule by introducing modal contribution coefficients predicted by a deep neural network (DNN) model. The DC rule enhances prediction accuracy by considering the characteristics of ground motion and the dynamic properties of a structural system. The DC rule provides more accurate predictions than the conventional rules, particularly for irregular response spectra and responses affected by higher modes. The efficiency and applicability of the DC rule are demonstrated by numerical investigations of multistory shear buildings and steel frame structures with regular and irregular shapes. The source codes, data, and trained models are available for download at https://github.com/tyongkim/ERD2.
Bioimaging and prospects of night pearls‐based persistence phosphors in cancer diagnostics
Authors: Shang Ruipu , Yang Feifei , Gao Ge , Luo Yu , You Hongpeng , Dong Lile 
Published: January 2024

AbstractInorganic persistent phosphors feature great potential for cancer diagnosis due to the long luminescence lifetime, low background scattering, and minimal autofluorescence. With the prominent advantages of near‐infrared light, such as deep penetration, high resolution, low autofluorescence, and tissue absorption, persistent phosphors can be used for deep bioimaging. We focus on highlighting inorganic persistent phosphors, emphasizing the synthesis methods and applications in cancer diagnostics. Typical synthetic methods such as the high‐temperature solid state, thermal decomposition, hydrothermal/solvothermal, and template methods are proposed to obtain small‐size phosphors for biological organisms. The luminescence mechanisms of inorganic persistent phosphors with different excitation are discussed and effective matrixes including galliumate, germanium, aluminate, and fluoride are explored. Finally, the current directions where inorganic persistent phosphors can continue to be optimized and how to further overcome the challenges in cancer diagnosis are summarized.
Adjuvant effect of antimicrobial photodynamic therapy (aPDT) in the treatment of diabetic foot ulcers: A case series
Authors: Ferreira Rita de Cassia , Cecatto Rebeca Boltes , Perez Silvana Torres , Mesquita‐Ferrari Raquel Agnelli , Bussadori Sandra Kalil , Duran Cinthya Cosme , Horliana Anna Carolina Tempestini , Fernandes Kristianne Porta Santos 
Published: January 2024

AbstractThis study aimed to evaluate the clinical evolution of patients with diabetic foot ulcer treated with antimicrobial photodynamic therapy (aPDT) using the Bates‐Jensen (BJ) scale. A total of 21 patients were monitored, with an average age of 58 years. Patients underwent the standard treatment protocol of the institution, supplemented with aPDT utilizing 0.01% methylene blue (MB) and laser irradiation (660 nm, 100 mW, 6 J per point). Following aPDT, the lesions were protected with hydrofiber dressings containing silver. The Bates‐Jensen Scale was employed at pre‐treatment and post‐aPDT sessions to assess lesion progression. The results demonstrated a significant difference between pre‐ and post‐treatment values in the overall BJ score. The use of MB in aPDT proved to be an effective, safe, well‐tolerated treatment with high patient adherence and the potential for implementation in the care of diabetic foot conditions.
Detection of acute and early‐delayed radiation‐induced changes in the white matter of the rat brain based on numerical processing of optical coherence tomography data
Authors: Achkasova Ksenia , Kukhnina Liudmila , Moiseev Alexander , Kiseleva Elena , Bogomolova Alexandra , Loginova Maria , Gladkova Natalia 
Published: January 2024

AbstractDetection of radiation‐induced changes of the brain white matter is important for brain neoplasms repeated surgery. We investigated the influence of irradiation on the scattering properties of the white matter using optical coherence tomography (OCT). Healthy Wistar rats undergone the irradiation of the brain right hemisphere. At seven time points from the irradiation procedure (2–14 weeks), an ex vivo OCT study was performed with subsequent calculation of attenuation coefficient values in the corpus callosum followed by immunohistochemical analysis. As a result, we discovered acute and early‐delayed changes characterized by the edema of different severity, accompanied by a statistically significant decrease in attenuation coefficient values. In particular, these changes were found at 2 weeks after irradiation in the irradiated hemisphere, while at 6‐ and 12‐week time points they affected both irradiated and contralateral hemisphere. Thus, radiation‐induced changes occurring in white matter during the first 3 months after irradiation can be detected by OCT.
Theoretical insights into the impact of hydrogen bonding interactions and proton‐transfer phenomena on the excited state of HBT‐TMS fluorophore: Solvent‐induced effects
Authors: Li Chaozheng , Liu Rivaille , Dong Hao 
Published: January 2024

AbstractInspired by the design of distinguished optical materials, novel organic molecules exhibiting excited state intramolecular proton‐transfer (ESIPT) characteristics have emerged as a prominent research topic. In this study, we focus on investigating the excited state dynamics of 2‐(5‐trifluoromethyl‐benzothiazol‐2‐yl)‐4,6‐bis‐trimethylsilanylethynyl‐phenol (HBT‐TMS), a novel color‐tunable multifunctional ESIPT emitter. By considering four different aprotic solvents with varying polarities, we confirm the influence of solvent polarity on photo‐induced hydrogen bonding interactions, charge redistribution, and associated ESIPT phenomena. Through comparison and quantification of the magnitudes of excited state reaction barriers in different solvents, our findings suggest that highly polar solvents facilitate the ESIPT reaction for HBT‐TMS fluorophore.
Illicit drug abuse and complexity of tibial shaft fracture based on AO/OTA classification: Is there any connection?
Authors: Sharafi Amirmohammad , Ghaderi Ali , Shahbazi Parmida , Ghaseminejad‐Raeini Amirhossein , Ramezani Akam , Soleimani Mohammad , Talebiyan Parham , Shafiei Seyyed Hossein 
Published: January 2024

AbstractPurposeIllicit drug abuse is a global epidemic afflicting millions worldwide. Several studies have investigated the contribution of this dependence as a risk factor for fracture, but its impacts on fracture severity have been rarely studied. The present study primarily aims to determine the relationship between illicit drug abuse and the severity of tibial shaft fractures.MethodsThis retrospective study consecutively included patients aged ≥18 years with tibial shaft fracture who attended Sina Tertiary Hospital, Tehran, Iran, between 2016 and 2021. The fracture patterns were assessed according to the Arbeitsgemeinschaft für Osteosynthesefragen Foundation/Orthopaedic Trauma Association classification. Participants were divided into three individual specialists into groups: simple (A), wedge (B) and multifragmentary (C) fractures. The association of illicit drug abuse and other recorded variables, including age, sex, body mass index (BMI), comorbidities, physical activity, smoking habits and mechanism of injury, was also examined and assessed in multivariate logistic regression.ResultsOf 219 patients, 26 were drug abusers, and 193 had no history of use. A total of 20 out of 26 drug abusers experienced a complex fracture, yielding a rate of 76.9%, while this rate for nonusers was 50.3% (97 out of 193), indicating a statistically significant difference between the two subgroups (p = 0.011). The smoking history also influenced the fracture pattern (p = 0.027) based on univariate analysis; however, using adjusted multivariate analysis yielded only illicit drug abuse (odds ratio = 3.495; confidence interval = 1.144–10.680) as a risk factor for more complex fractures.ConclusionThe evidence from this study suggests that complexity and fracture patterns can depend on illicit drug abuse history.Level of EvidenceLevel III.
Proteome encoded determinants of protein sorting into extracellular vesicles
Authors: Waury Katharina , Gogishvili Dea , Nieuwland Rienk , Chatterjee Madhurima , Teunissen Charlotte E. , Abeln Sanne 
Published: January 2024

AbstractExtracellular vesicles (EVs) are membranous structures released by cells into the extracellular space and are thought to be involved in cell‐to‐cell communication. While EVs and their cargo are promising biomarker candidates, sorting mechanisms of proteins to EVs remain unclear. In this study, we ask if it is possible to determine EV association based on the protein sequence. Additionally, we ask what the most important determinants are for EV association. We answer these questions with explainable AI models, using human proteome data from EV databases to train and validate the model. It is essential to correct the datasets for contaminants introduced by coarse EV isolation workflows and for experimental bias caused by mass spectrometry. In this study, we show that it is indeed possible to predict EV association from the protein sequence: a simple sequence‐based model for predicting EV proteins achieved an area under the curve of 0.77 ± 0.01, which increased further to 0.84 ± 0.00 when incorporating curated post‐translational modification (PTM) annotations. Feature analysis shows that EV‐associated proteins are stable, polar, and structured with low isoelectric point compared to non‐EV proteins. PTM annotations emerged as the most important features for correct classification; specifically, palmitoylation is one of the most prevalent EV sorting mechanisms for unique proteins. Palmitoylation and nitrosylation sites are especially prevalent in EV proteins that are determined by very strict isolation protocols, indicating they could potentially serve as quality control criteria for future studies. This computational study offers an effective sequence‐based predictor of EV associated proteins with extensive characterisation of the human EV proteome that can explain for individual proteins which factors contribute to their EV association.
Synthesis and characterization of a highly fluorescent benzofuran dimer derived from estradiol
Authors: Santiago‐Sampedro Gerardo I. , Mayorquín‐Torres Martha C. , Aguilar‐Granda Andrés , Iglesias‐Arteaga Martin A. 
Published: January 2024

AbstractPd‐catalyzed cyclization of a fluorescent dimer in which two cores of the potent estrogenic estradiol are bridged by the 1,4‐diethynil benzene moiety led to a steroid dimer bearing the 1,4‐di(benzofuran‐2‐yl)benzene. The obtained compound showed an intense blue fluorescence characterized by a broad emission band between 350 and 550 nm, with four maxima at 384, 403, 435, and 456 nm. The benzofuran dimer showed an 18‐fold increased quantum yield compared with that of its synthetic precursor.
Role of Additional MRI‐Based Morphologic Measurements on the Performance of VI‐RADS for Muscle‐Invasive Bladder Cancer
Authors: Gong Yu , Cheng Yi , Zhang Jing , Bao Mei‐Ling , Zhu Fei‐Peng , Sun Xue‐Ying , Zhang Yu‐Dong 
Published: January 2024

BackgroundVesical Imaging‐Reporting and Data System (VI‐RADS) is a pathway for the standardized imaging and reporting of bladder cancer staging using multiparametric (mp) MRI.PurposeTo investigate additional role of morphological (MOR) measurements to VI‐RADS for the detection of muscle‐invasive bladder cancer (MIBC) with mpMRI.Study TypeRetrospective.PopulationA total of 198 patients (72 MIBC and 126 NMIBC) underwent bladder mpMRI was included.Field Strength/Sequence3.0 T/T2‐weighted imaging with fast‐spin‐echo sequence, spin‐echo‐planar diffusion‐weighted imaging and dynamic contrast‐enhanced imaging with fast 3D gradient‐echo sequence.AssessmentVI‐RADS score and MOR measurement including tumor location, number, stalk, cauliflower‐like surface, type of tumor growth, tumor‐muscle contact margin (TCM), tumor‐longitudinal length (TLL), and tumor cellularity index (TCI) were analyzed by three uroradiologists (3‐year, 8‐year, and 15‐year experience of bladder MRI, respectively) who were blinded to histopathology.Statistical TestsSignificant MOR measurements associated with MIBC were tested by univariable and multivariable logistic regression (LR) analysis with odds ratio (OR). Area under receiver operating characteristic curve (AUC) with DeLong's test and decision curve analysis (DCA) were used to compared the performance of unadjusted vs. adjusted VI‐RADS. A P‐value <0.05 was considered statistically significant.ResultsTCM (OR 9.98; 95% confidence interval [CI] 4.77–20.8), TCI (OR 5.72; 95% CI 2.37–13.8), and TLL (OR 3.35; 95% CI 1.40–8.03) were independently associated with MIBC at multivariable LR analysis. VI‐RADS adjusted by three MORs achieved significantly higher AUC (reader 1 0.908 vs. 0.798; reader 2 0.906 vs. 0.855; reader 3 0.907 vs. 0.831) and better clinical benefits than unadjusted VI‐RADS at DCA. Specially in VI‐RADS‐defined equivocal lesions, MOR‐based adjustment resulted in 55.5% (25/45), 70.4% (38/54), and 46.4% (26/56) improvement in accuracy for discriminating MIBC in three readers, respectively.Data ConclusionMOR measurements improved the performance of VI‐RADS in detecting MIBC with mpMRI, especially for equivocal lesions.Level of Evidence3Technical EfficacyStage 2
Association between NTCP hepatic expression and inflammation/fibrosis as well as gender‐specific differences in chronic HBV‐infected patients
Authors: Shi Jingyi , Wang Xu , Qi Wenqian , Wang Song , Fu Yao , Zhang Yonggui , Zhang Qian , Han Liang , Xu Yanhui , Duan Honglei , Liu Jia , Cong Xianling , Zhou Changyu , Zhao Ping , Wang Jiangbin 
Published: January 2024

AbstractTo investigate the relationship between the expression of hepatitis B virus (HBV) functional receptor sodium taurocholate cotransporting polypeptide (NTCP) with disease progression and gender‐specific differences in chronic HBV‐infected patients. Liver samples were collected from chronic HBV‐infected patients who underwent percutaneous liver biopsy or liver surgery. HBV DNA levels and the mRNA and protein expression levels of NTCP in liver tissues were determined. The relationship between NTCP expression and HBV DNA levels, inflammatory activity, fibrosis, and gender‐specific differences were analyzed. A total of 94 chronic HBV‐infected patients were included. Compared with patients with a METAVIR score of A0‐1 or F0‐1, patients with score of A2 or F2/F3 had a relatively higher level of NTCP expression. NTCP levels were positively correlated with HBV DNA levels. The inflammatory activity scores and fibrosis scores of women <50 years were significantly lower than those of women ≥50 years and age‐matched males. In patients with score A0‐2 or F0‐3, women <50 years have lower NTCP expression level compared to women ≥50 years and age‐matched males. NTCP can promote the disease progression by affecting the viral load of HBV. The NTCP expression difference may be why male and postmenopausal women are more prone to disease progression than reproductive women.
Gastrointestinal manifestations seen in pediatric patients diagnosed with small fiber neuropathy
Authors: Nabar Shruti , Fernandez Jenelle , Prakash Vikram , Safder Shaista 
Published: January 2024

AbstractObjectivesSmall fiber neuropathy (SFN) affects the fibers involved in cutaneous and visceral pain and temperature sensation and are a crucial part of the autonomic nervous system. Autonomic dysfunction secondary to SFN and autoimmune receptor antibodies is being increasingly recognized, and gastrointestinal (GI) manifestations include constipation, early satiety, nausea, vomiting, and diarrhea. Enteric nervous system involvement may be a possible explanation of abnormal GI motility patterns seen in these patients.MethodsChildren suspected to have SFN based on symptoms underwent skin biopsy at the Child Neurology clinic at Arnold Palmer Hospital for Children, which was processed at Therapath™ Neuropathology. SFN was diagnosed using epidermal nerve fiber density values that were below 5th percentile from the left distal leg (calf) as reported per Therapath™ laboratory.ResultsTwenty‐six patients were diagnosed with SFN. Retrospective chart review was performed, including demographic data, clinical characteristics, and evaluation. A majority of patients were white adolescent females. Autonomic dysfunction, including orthostasis and temperature dysregulation were seen in 61.5% of patients (p = 0.124). Somatosensory symptoms, including pain or numbness were seen in 85% of patients (p < 0.001). GI symptoms were present in 85% of patients (p < 0.001) with constipation being the most common symptom seen in 50% of patients. This correlated with the motility testing results.ConclusionsPediatric patients with SFN commonly have GI symptoms, which may be the main presenting symptom. It is important to recognize and look for symptoms of small fiber neuropathy in children with refractory GI symptoms that may explain multisystemic complaints often seen in these patients.
Monitoring pediatric eosinophilic esophagitis disease activity using an unsedated blind esophageal brushing model: A pilot study
Authors: Thomas Jessina , Deb Chirajyoti , Bittar Khaled , Bornstein Jeffrey , Mehta Devendra , Smadi Yamen 
Published: January 2024

AbstractBackgroundRecurrent upper endoscopies are essential for monitoring therapy response and disease activity in patients with eosinophilic esophagitis (EoE), leading to increased costs, procedural complications, and anesthesia exposure. The aim of this study was to examine an office‐based model using serial sedation‐free blind esophageal epithelial brushing (BEEB) to monitor therapy response through eosinophil‐derived neurotoxin (EDN) levels and guide therapy plans in pediatric EoE patients.MethodsEoE patients (≤21 years of age) were enrolled in this prospective study. Subjects were placed on dietary, pharmacologic, or combination therapy with the goal of inducing or maintaining remission. To assess response to sequential interventions, subjects underwent sequential sedation‐free BEEBs through nasogastric tubes to measure EDN levels. Based on serial brushings, an individual plan of diet, medications, or a combination of both was created for each subject, and a final endoscopy was then performed to validate the accuracy of the individual plans.ResultsTwenty‐four subjects completed the study. The average peak eosinophil count in patients with active EoE was 58.1 ± 30.8 eosinophils per high‐power field and mean EDN level was 165.2 ± 191.3 μg/mL. A total of 42 BEEBs were completed. Individual therapy plans based on sequential BEEB were accurate in 19 out of the 24 patients (79%) and specifically nine out of 10 patients (90%) treated with elimination diets.ConclusionThis study suggests that office‐based sedation‐free BEEBs can be used to monitor therapy response and disease activity in pediatric EoE patients.
Factors associated with successful electrolarynx use after total laryngectomy, a multi‐institutional study
Authors: Pan Cassie , Andrews Leah I. B. , Johnson Emily , Bhatt Neel K. , Rizvi Zain H. 
Published: January 2024

AbstractObjectiveTo identify characteristics associated with successful electrolarynx (EL) use after total laryngectomy (TL).MethodsRecords of 196 adults who underwent TL from 03/15/2012 to 03/15/2022 at the University of Washington and Puget Sound Veterans Affairs were reviewed. Characteristics included age, Charlson Comorbidity Index, social support, pre‐operative radiation (RT) and chemoradiation (CRT), and 6‐month post‐TL swallow status. EL success was evaluated using pre‐defined criteria of intelligibility, reliability, and independence with use. Poisson regressions and robust standard error estimates were used to estimate unadjusted risk ratios for each characteristic. Statistically significant characteristics were included in multivariate analysis (MVA) to estimate adjusted risk ratios.ResultsMedian age was 64, median Charlson Comorbidity Index was 5, 170 (87%) were male, 159 (81%) had high social support, and 159 (81%) attained post‐TL full‐oral diet. Pre‐operatively, 110 (56%) had RT, including 55 (28%) with CRT. Ninety‐three (47%) met our criteria for EL success. Characteristics significantly associated with EL success included social support (p = .037) and post‐TL full‐oral diet (p = .037); both approached significance on MVA. EL success varied by pre‐operative treatment on univariate (p = .005) and MVA (p = .014). Compared to no prior RT or CRT, the probability of EL success was 29% higher with prior RT and 29% lower with prior CRT in MVA, although these associations did not reach significance.ConclusionsIn this retrospective review, EL success correlated with high social support, post‐TL full‐oral diet, and pre‐operative treatment history. These results warrant validation in a larger prospective study to help guide the choice of voice rehabilitation modalities or intensified speech therapy.Level of Evidence4.
Overcoming NMR line broadening of nitrogen containing compounds: A simple solution
Authors: Ma Junhe , Ye Qingmei , Green Rebecca A. , Gurak John , Ayers Sloan , Huang Yande , Miller Scott A. 
Published: January 2024

AbstractThis study presents a straightforward solution to the challenge of elucidating the structures of nitrogen containing compounds undergoing isomerization. When spectral line broadening occurs related to isomerization, be it prototropic tautomerism or bond rotations, this poses a significant obstacle to structural elucidation. By adding acids, we demonstrate a simple approach to overcome this issue and effectively sharpen NMR signals for acid stable prototropic tautomers as well as the conformational isomers containing a morpholine or piperazine ring.