bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional Chinese Medicine-based Treatment in Cardiovascular Disease: Potential Mechanisms of Action
Authors: Li Lanlan , Ran Yutong , Wen Jiao , Lu Yirui , Liu Shunmei , Li Hong , Cheng Min 
Published: February 2024

:
Cardiovascular Disease (CVD) is the leading cause of morbidity and death worldwide
and has become a global public health problem. Traditional Chinese medicine (TCM) has been
used in China to treat CVD and achieved promising results. Therefore, TCM has aroused significant
interest among pharmacologists and medical practitioners. Previous research showed that
TCM can regulate the occurrence and development of atherosclerosis (AS), ischemic heart disease,
heart failure, myocardial injury, and myocardial fibrosis by inhibiting vascular endothelial
injury, inflammation, oxidant stress, ischemia-reperfusion injury, and myocardial remodeling. It
is well-known that TCM has the characteristics of multi-component, multi-pathway, and multitarget.
Here, we systematically review the bioactive components, pharmacological effects, and
clinical application of TCM in preventing and treating CVD.
Evaluating the Intensity of Exposure to MTV Shuga, an Edutainment Program for HIV Prevention: Cross-Sectional Study in Eastern Cape, South Africa
Authors: Mulwa Sarah , Baker Venetia , Cawood Cherie , Khanyile David , O'Donnell Dominique , Sarrassat Sophie , Cousens Simon , Birdthistle Isolde 
Published: February 2024

Background
MTV Shuga is an edutainment campaign designed to equip young people with knowledge, motivation, and informed choices to protect themselves from HIV infection. From 2019 to 2020, a total of 10 episodes of a new dramatic series, MTV Shuga “Down South 2” (DS2), were broadcast via television and the internet, alongside complementary media activities.

Objective
This study aims to investigate whether the intensity of DS2 exposure was linked with positive HIV prevention outcomes in a setting with high HIV prevalence and relatively low levels of HIV testing.

Methods
We analyzed data from a web-based survey of participants aged 15 to 24 years in South Africa in 2020. The survey was promoted via social media platforms of schools, universities, and communities in Eastern Cape, South Africa. The primary exposure of interest was the intensity of exposure to DS2, measured by the number of episodes of DS2 watched on the television or the internet or listened to on the radio (out of 10 episodes). Individuals who had not watched or listened to any DS2 episode were classified according to other MTV Shuga content that they had accessed. We estimated associations between the intensity of DS2 exposure and HIV-related outcomes, including knowledge of HIV status, awareness of HIV self-testing (HIVST) and pre-exposure prophylaxis (PrEP), uptake of HIVST, and demand for HIVST and PrEP, adjusting for potential confounders using multivariable logistic regression.

Results
Among the 3431 survey participants, 827 (24.1%) were exposed to DS2. Specifically, 18.1% (622/3431) watched or listened to only 1 DS2 episode, and 2.4% (82/3431), 1.7% (58/3431), and 1.8% (62/3431) watched or listened to 2 to 4, 5 to 7, and 8 to 10 DS2 episodes, respectively. Increasing the exposure to DS2 was associated with improvements in most outcomes. Exposure to multiple episodes (eg, 2-4, 5-7, and 8-10) was associated with successively higher odds of knowing one’s HIV status, awareness of PrEP and HIVST, and uptake of HIVST compared with no MTV Shuga exposure, albeit with statistical uncertainty around some estimates. The interest in using HIVST or PrEP was high overall (>80%), with no measurable differences by DS2 intensity.

Conclusions
We found evidence consistent with a dose-response relationship between MTV Shuga DS2 exposure and outcomes, including knowledge of HIV status, awareness and uptake of HIVST, and awareness of PrEP among young people in Eastern Cape. This indicates that greater engagement with a youth-focused edutainment campaign can improve HIV testing and prevention options in a setting and population with high need. However, only a few participants accessed multiple DS2 episodes despite its availability on multiple media platforms. We conclude that there is potential to benefit more young people by increasing access to and interest in the show.
Adapting a Dutch Web-Based Intervention to Support Family Caregivers of People With Dementia in the UK Context: Accelerated Experience-Based Co-Design
Authors: Scheibl Fiona , Boots Lizzy , Eley Ruth , Fox Christopher , Gracey Fergus , Harrison Dening Karen , Oyebode Jan , Penhale Bridget , Poland Fiona , Ridel Gemma , West Juniper , Cross Jane L 
Published: February 2024

Background
Around 700,000 family caregivers provide unpaid care for 900,000 people living with dementia in the United Kingdom. Few family caregivers receive support for their own psychological needs and funding for community respite services has declined. These trends are seen across Europe as demographic and budgetary pressures have intensified due to public spending cuts arising from the 2008 financial crisis and the COVID-19 pandemic. The World Health Organization has prioritized the need to expand the provision of support for caregivers and families of people with dementia by 2025. Web-based interventions have the potential for development as they require modest investment and can be accessed by family caregivers at home. Further cost benefits can be realized by adapting existing interventions with demonstrated effectiveness for new contexts. This paper reports initial findings from the CareCoach study, which is adapting Partner in Balance (PiB), a web-based coaching intervention developed in the Netherlands, for family caregivers in the United Kingdom.

Objective
This study aims to work with unpaid family caregivers and staff in adapting the Dutch web-based support tool PiB to improve its acceptability and usability for use in the United Kingdom.

Methods
Accelerated Experience-Based Co-Design (AEBCD) was used with caregivers, staff, and core stakeholders. Interviews, workshops, and stakeholder consultations were conducted. Data were analyzed iteratively. Recommendations for the redesign of PiB for use across the United Kingdom were adjudicated by the study Adaptation Working Party.

Results
Sixteen caregivers and 17 staff took part in interviews. Thirteen caregivers and 17 staff took part in workshops. Most (n=26) participants were White, female, and retired. All except 4 caregivers (2 male and 2 female) found the PiB’s offer of web-based self-help learning acceptable. Caregivers identified complexity and lack of inclusivity in some wording and video resources as problematic. The staff took a stronger perspective on the lack of inclusivity in PiB video resources. Staff and caregivers coproduced new inclusive wording and recommended creating new videos to adapt PiB for the UK context.

Conclusions
AEBCD methods facilitated the engagement of caregivers and staff and advanced the adaptation of the PiB complex intervention. An important addition to the AEBCD method in this process was the work of an Adaptation Working Party, which adjudicated and agreed to new wording where this could not be established in consultation with caregivers and staff.

Trial Registration
ISRCTN Registry ISRCTN12540555; https://doi.org/10.1186/ISRCTN12540555
Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study
Authors: Gabb Victoria Grace , Blackman Jonathan , Morrison Hamish Duncan , Biswas Bijetri , Li Haoxuan , Turner Nicholas , Russell Georgina M , Greenwood Rosemary , Jolly Amy , Trender William , Hampshire Adam , Whone Alan , Coulthard Elizabeth 
Published: February 2024

Background
Sleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population.

Objective
This study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD.

Methods
We will deliver a feasibility and acceptability study alongside a prospective observational cohort study assessing sleep and cognition longitudinally in the home environment. Adults aged older than 50 years who were diagnosed with mild to moderate dementia or mild cognitive impairment (MCI) due to probable AD or LBD and age-matched controls will be eligible. Exclusion criteria include lack of capacity to consent to research, other causes of MCI or dementia, and clinically significant sleep disorders. Participants will complete a cognitive assessment and questionnaires with a researcher and receive training and instructions for at-home study tasks across 8 weeks. At-home study tasks include remote sleep assessments using wearable devices (electroencephalography headband and actigraphy watch), app-based sleep diaries, online cognitive assessments, and saliva samples for melatonin- and cortisol-derived circadian markers. Feasibility outcomes will be assessed relating to recruitment and retention, data completeness, data quality, and support required. Feedback on acceptability and usability will be collected throughout the study period and end-of-study interviews will be analyzed using thematic analysis.

Results
Recruitment started in February 2022. Data collection is ongoing, with final data expected in February 2024 and data analysis and publication of findings scheduled for the summer of 2024.

Conclusions
This study will allow us to assess if remote testing using smart devices and wearable technology is a viable alternative to traditional sleep measurements, such as polysomnography and questionnaires, in older adults with and without MCI or dementia due to AD or LBD. Understanding participant experience and the barriers and facilitators to technology use for research purposes and remote research in this population will assist with the development of, recruitment to, and retention within future research projects studying sleep and cognition outside of the clinic or laboratory.

International Registered Report Identifier (IRRID)
DERR1-10.2196/52652
Characteristics of patients associated with antibiotic use among gastrointestinal surgery at the Academic Hospital, Universitas Gadjah Mada
Authors: Saskiya Pingki Arum , Taufiqurohman  , Wiedyaningsih Chairun 
Published: February 2024

Digestive surgery is a treatment for diseases of the parts of the body involved in digestion, which has a fairly high risk of infection. The study aimed to obtain a description of the types and specific characteristics of patients and the rationality of antibiotic use among digestive surgery patients. This study was conducted using observational analysis. Data on antibiotic use was collected prospectively from medical records of digestive surgery inpatients at the Academic Hospital Universitas Gadjah Mada (UGM) from January to March 2023. The Gyssens method was used to evaluate qualitatively the use of antibiotics. A total of 76 patients met the inclusion and exclusion criteria. No significant difference between the number of male and female patients was identified. The results showed that 24 (31.58%) acute appendicitis patients are the primary diagnosis most often encountered in patients undergoing digestive surgery. The most frequently used prophylactic antibiotics for digestive surgery patients were ceftriaxone (53.85%) and cefazolin (41.03%). Meanwhile, the most frequently used therapeutic antibiotics were ceftriaxone (41.94%) and levofloxacin (29.03%). The Gyssens analysis shows that large irrational use of antibiotics is still observed.
Specifications of Sugar Cane Varieties Based on Land Characteristic and Typology
Authors: Basuki Basuki , Sari Vega Kartika 
Published: February 2024

The productivity of sugarcane is decreasing and there are more and more varieties in circulation. The decrease in productivity is caused by the incompatibility of each variety of land typology. The purpose of this research is to arrange the right varieties in increasing the productivity of sugarcane. The research method is surveying and matching. Parameters used include soil texture, land type conditions, soil drainage conditions, and rainfall. Based on the research results, the total working area of 11,866.81 ha was divided into 4 land typologies, namely BHJ with an area of 2,910.95 hectares (24.53%), BPJ with an area of 2,047.44 hectares (17.25%), RHL an area of 471.12 hectares (3.97%), RPL area of 1,527.01 hectares (12.87%). Based on land typology the suitability of BHJ varieties of sugarcane suitable varieties PSMLG 1 AGRIBUN, VMC76-16, NX03, PS921, PSJT941, PSDK923; BPJ land typology of suitable varieties Cenning, VMC71-238, PA0218, NX01, Kentung, AASAgribun, PSJT 941, PSDK923, PSBK051, NX02; RHL land typology of suitable varieties PSKA 942, PA028, PSBK061, VMC76-16, AMS Agribun, ASA Agribun, PSJT941, NXI4T, MOJO01, Bululawang; RPL land typology of suitable varieties PS881, TLH02, PSKA 942, PSBK061, PS091, PSJK922, VMC86-550, PS862, PS851, PSCO902, Kidang Kencana, PS882, PS092, PS865, PS864, NXI4T, Bululawang. Keywords: Soil drainage, Soil texture, Soil type, Soil typology, Sugarcane varieties.
Application of Agro-industrial Solid Waste as Biochar for Iron (II) Removal from Aqueous Solution
Authors: Rusnam Rusnam , Yanti Nika Rahma , Puari Aninda Tifani , Sari Nurmala 
Published: February 2024

In recent years, various industrial activities have introduced a high concentration of iron in the waterbody which causes serious problem to environment. This paper proposed the application of Exhausted Coffee Husk (ECH) as the biosorbent (BS) for removing iron (Fe) (II) in the aqueous solution. The ECH was carbonized into biochar before performing biosorption of the heavy metal ion. The effect of carbonization temperature, time and rate on the performance of the ECH biochar for removing Fe (II) were evaluated. The percentage of removal efficiency (RE) and the capacity of biosorption (mg/g) were considered as the determining parameters. The pyrolysis temperature was varied in a range of 200-600 °C with 50 °C of interval, while the time was in between 1h – 3h with a n interval of 0.5 h, and the temperature gradient of 5 – 25°C/min. The results showed that the temperature had a significant effect on the properties of the ECH biochar as BS for Fe (II). The temperature of 550 °C, at 1.5 h of time and 25 °C/min was chosen as the suggested carbonization temperature of biochar from ECH for biosorption of Fe (II). Keywords: Agro-industrial solid waste, Biosorption, Carbonization, Exhausted coffee husk (ECH), Heavy metal.
Performance Evaluation of Ball Mill Type Grinding Machine for Particle Size Reduction of Porang Glucomannan Crystals
Authors: Pramuhadi Gatot , Sutejo Agus , Wicaksono Dionisius Dwi 
Published: February 2024

A wide gap in the price of glucomannan flour and porang tubers leads to develop a machine to process tubers into fine flour with good performance. The purpose of this research was to analyze and determine the performance of a ball mill machine on the flour yield as well as its quality. Research was conducted at PT Daud Teknik Maju Pratama from January – May 2023. Testings were carried out under two treatment factors, namely rotational speed (21.2 and 41.6 rpm) and processing time (0.5 h, 1.0 h, 1.5 h, 2 h). The test was carried out using 150 g sample for each treatment with three replications. The response variables included capacity, percentage of size reduction, material losses, engine power, and flour quality. The results showed that the optimum capacity of the ball mill machine was 12.5 kg/batch. The highest percentage of size reduction was 96.27% and the lowest material loss (3.73%) were obtained at 21.2 rpm for 0.5 h of miling process. Treatment with 41.6 rpm for 2 h produced the best flour quality with moisture content of 11.87% and fine flower yield of 63.97% passing through 100-mesh sieve. The power requirements of electric motors at 21.2 rpm and 41.6 rpm were 0.8063 kW and 0.9101 kW, respectively. The best milling capacity (1.560 g/min) was resulted at rotational speed of 62.27% CS. The ball mill machine showed superior results as compared to a disk mill which was not able to grind the glucomannan crystals up to 100-mesh size.Keywords: Ball mill, Glucomannan flour, Performance test, Porang, Refining.
Evaluation of The Chemical Properties, Chewiness Level, and Sensory of Yellow Pumpkin (Cucurbita moschata) Jelly Candy in Various Ratios of Caragenan and Gum Arabic
Authors: Astuti Sussi , Nawansih Otik , Hidayati Sri , Anggraini Octavia Sopha 
Published: February 2024

This study aims to determine the effect of carrageenan and gum arabic formulations on chemical properties, level of elasticity, and sensory properties of pumpkin jelly candy and to obtain the right formulation of carrageenan and gum arabic to produce good quality jelly candy. The study was arranged in a Completely Randomized Block Design with a single factor and 4 replications. The treatment was the ratio of carrageenan and gum arabic consisted of 5%:0% (K1), 4%:1% (K2), 3%:2% (K3), 2%:3% (K4), 1%:4 % (K5). The data obtained were analyzed for homogeneity with the Barlett test, ANOVA, and the Tuckey test at the 5% level. Determination of the best treatment for pumpkin jelly candy was determined by the De Garmo method. The results showed that the best jelly candy was the K3 treatment (3% carrageenan; 2% gum arabic) which resulted in a texture score of 3.80 (chewy), color with a score of 3.97 (dark yellow), taste with a score of 4.11 (like ), water content of 7.66%, ash content of 0.99%, reducing sugar content of 14.31%, and sucrose content of 27.7%. Formulation of carrageenan and gum arabic significantly affected the chemical properties, level of elasticity, and sensory properties of pumpkin jelly candy. Keywords: Gum Arabic, Carrageenan, Jelly candy, Pumpkin.
Inorganic Nutrient Composition and Frequency of Ratoon on Kangkong (Ipomoea reptans Poir) in Pot Trial Using Ultisol Media for Urban Farming
Authors: Khodijah Nyayu Siti , Ningsih Ulfa Riska , Ningsih Ulfa Riska , Santi Ratna Santi 
Published: February 2024

Kangkong (Ipomoea reptans) is a type of vegetable that is quite easy to cultivate. Cultivation of kangkong with a ratoon system is more efficient in cultivation time and input, and harvesting can be done more than once. Yield of ratoon cultivation system is influenced by ratoon frequency and nutrition. This study aims to determine the effect of inorganic nutrient composition and ratoon frequency. The research was conducted from January to March 2022 at the University of Bangka Belitung. The research method used factorial Completely Randomized Design (CRD). The first factor was the composition of inorganic nutrients, consisting of N1 (AB mix), N2 (NPK + Gandasil D), and N3 (NPK + Growmore). The second factor is the frequency of ratoon, consisting of R0 (no ratoon), R1 (ratoon frequency of 1), R2 (ratoon frequency of 2), and R3 (ratoon frequency of 3). The results revealed that treatment combinations had no significant effect on all observed variables. Composition of inorganic nutrients have a significant effect on root variables with the AB mix treatment as the best. Ratoon frequency treatment had a significant effect on almost all variables (except total number of leaves) with the best treatment being without ratoons (R0). The average total number of leaves of kangkong plants showed the highest yield in the N3R3 treatment, reaching 14.52 strands and the lowest yield in the N1R1 treatment with 12.81 strands. Keywords: Kangkong, Inorganic nutrient, Ratoon frequency, Plant growth, Yield,
Designing Web-Based Mess and Dormitory Booking Applications
Authors: Darwin Widya , Zulfadli Zulfadli , Yuliady Ilham , Jusmardi Jusmardi , Deswina Melri 
Published: February 2024

Perancangan Aplikasi Booking Mess dan Asrama berbasis web merupakan langkah inovatif dalam meningkatkan efisiensi dan kenyamanan layanan perumahan bagi mahasiswa. Aplikasi ini bertujuan untuk menggantikan sistem pemesanan yang masih manual dengan solusi berbasis teknologi web yang memudahkan mahasiswa mengakses informasi dan melakukan reservasi secara praktis. Metode yang digunakan adalah waterfall, dimana proses perancangan perangkat lunak berurutan yang berkembang ke arah bawah seperti air terjun dan termasuk metode yang cocok untuk digunakan dalam perancangan sistem yang spesifikasinya tidak berubah-ubah dan bersifat sistematis serta berurutan, sehingga setiap tahap dalam proses perancangan akan dimulai apabila tahap sebelumnya telah selesai dikerjakan. Terdapat 5 tahap dalam metode waterfall, yaitu analisis, design, implementasi, testing, dan maintenenance. Memungkinkan pengguna dengan mudah memeriksa ketersediaan, fasilitas, dan tarif mess serta asrama secara real-time. Melalui sistem pemesanan online yang terintegrasi, mahasiswa dapat melakukan reservasi kamar dengan cepat, efisien, dan bebas hambatan. Penerapan teknologi web diharapkan dapat mengurangi kerumitan dalam pengelolaan perumahan mahasiswa, menghemat waktu, dan meningkatkan transparansi informasi. Penggunaan Aplikasi Booking Mess dan Asrama berbasis web tidak hanya mengoptimalkan pengelolaan perumahan, tetapi juga meningkatkan pengalaman mahasiswa dalam mendapatkan tempat tinggal yang sesuai dengan preferensi dan kebutuhan mereka. Dengan demikian, aplikasi ini diharapkan dapat memberikan kontribusi positif terhadap kemajuan teknologi informasi di lingkungan akademis dan memberikan solusi modern untuk kebutuhan perumahan mahasiswa.
Manajemen Karir dan Pengembangan Diri Mahasiswa: Perbandingan Strategi pada Jalur Masuk Perguruan Tinggi
Authors: Bahar Andrizal , Giatman M , Maksum Hasan 
Published: February 2024

The aim of this study is to compare career management strategies and levels of self-development among automotive engineering students at FT UNP who enrolled in 2019, particularly at the fourth stage of their studies. The research sample comprises 60 students, with 20 students from each admission path: SNMPTN, SBMPTN, and Independent Selection. The analysis employs ANOVA to address two research hypotheses regarding the differences in career management strategies and levels of self-development among the three admission paths.
The results of the study significantly support the first hypothesis, indicating a meaningful difference in career management strategies among students admitted through SNMPTN, SBMPTN, and Independent Selection. Similarly, the second hypothesis is also confirmed, demonstrating a significant difference in the level of self-development among students from the three admission paths.
This research provides valuable insights into how automotive engineering students navigate their careers and self-development through various admission paths. The practical implications of the study can offer guidance to academic institutions and stakeholders to enhance the effectiveness of career management and student self-development, taking into account the diverse characteristics and needs of students from different admission paths.
Introduksi Imbuhan Pakan dalam meningkatkan Minat Budidaya Ikan di Desa Nagrog
Authors: Haetami Kiki , Mulyani Yuniar , Hasbuna Abun 
Published: February 2024

Desa Nagrog merupakan salah satu desa yang memiliki banyak potensi salah satunya dalam bidang perikanan. Melalui kegiatan pengabdian masyarakat yaitu program Pengabdian kepada Masyarakat yang berlangsung dari 6 Januari 2023 - 13 Maret 2023 dengan tujuan memberikan pengetahuan untuk memberdayakan masyarakat desa Nagrog melalui Inroduksi Imbuhan Pakan dalam meningkatkan minat Budidaya Ikan”. Selain itu diadakan kegiatan ini untuk mengetahui antusias warga dalam melakukan budidaya ikan. Kegiatan ini dihadiri oleh masyarakat khususnya Gabungan Kelompok Tani (Gapoktan). Hasil yang telah dicapai pada kegiatan ini yaitu masyarakat telah memahami potensi dalam bidang perikanan desa Nagrog serta mengetahui tingkat antusias masyarakat di Desa Nagrog. Kata kunci: Nagrog, Budidaya, Perikanan, Pemberdayaan,