bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemodelan Evakuasi pada Ruang Koridor dengan Cellular Automata berbasis Perilaku Manusia
Authors: Mu'arifin Mu'arifin , Harsono Tri , Barakbah Ali Ridho 
Published: November 2023

Sebagai salah satu negara yang berada di garis khatulistiwa Indonesia menjadi salah satu negara yang memiliki potensi terjadinya bencana Gempa Bumi cukup tinggi. Pencegahan mengurangi jumlah korban adalah prioritas dalam penanganan ketika terjadi bencana, baik bencana gempa bumi maupun bencana lainya. Korban akibat bencana gempa bumi secara umum berada di dalam gedung. Jika struktur bangunan gedung tidak dibuat dengan baik maka potensi jumlah korban akan meningkat. Salah satu cara untuk mengurangi jumlah korban akibat gempa bumi adalah membuat sistem evakuasi dengan baik. Sistem evakuasi yang baik akan bisa menjadi petunjuk pengunjung gedung ketika terjadi bencana. Sistem evakuasi tentu akan berjalan dengan baik jika didukung dengan mental dari dalam diri korban dengan baik. Salah satu penyebab dari kegagalan sistem evakuasi adalah kepanikan dari dalam diri korban. Jika korban mengalami kepanikan saat terjadi bencana maka sistem evakuasi tidak dapat berjalan dengan baik dan berpotensi meningkatnya jumlah korban. Analisa dampak kepanikan dalam sebuah sistem evakuasi juga menjadi penentu keberhasilan sebuah sistem evakuasi.
Kombinasi Crossover dan Mutasi Terbaik pada Algoritma Genetika dalam Penjadwalan Mata Kuliah
Authors: Fajarlestari Maria Karmelia , Suban Ignasius Boli 
Published: November 2023

Pada proses penerapanya algoritma Genetika mempunyai operator crossover dan mutasi. Operator crossover mempunyai beberapa jenis dan operator mutasi dilakukan menurut besar probabilitasnya. Penggunaan crossover dan besar probabilitas menjadi salah satu masalah dalam penerapan algoritma Genetika karena dalam pemilihanya ditentukan secara random. Tujuan penelitian ini untuk mencari kombinasi paling baik pada jenis crossover dan besar probabilitas mutasi dalam memecahkan masalah penjadwalan. Kombinasi terbaik adalah kombinasi yang paling banyak menghasilkan hasil optimal. Algoritma Genetika diterapkan dalam permasalahan penjadwalan mata kuliah, kemudian hasil penerapanya dianalisis berdasarkan jenis mutasi dan besar probabilitas yang digunakan. Hasilnya dari semua kombinasi operator yang telah diuji coba untuk menyelesaikan masalah yang sama, ada satu kombinasi operator crossover dan mutasi yang memiliki rata-rata hasil terbaik yaitu kombinasi antara jenis crossover dua-titik dengan besar probabilitas mutasi 3%.
Dampak PPKM Darurat Jawa-Bali Terhadap Pelaku Usaha Coffee Shop Pada Masa Pendemi Covid-19 Di Kecamatan Wonocolo Kota Surabaya
Authors: Janah Miftakhul , Istigfarina Ulfah , Lamiah Ni`matul , Faizur Rohman Moh 
Published: November 2023

Abstract: This study aims to determine the impact of the implementation of restrictions on community activities or the Java-Bali emergency PPKM which is an effort from the government to overcome the spread of the covid-19 virus during the current pandemic. The impact of the implementation of this community restriction is very large and is felt by many people, starting from employees, students, and activities that are usually carried out in person/face to face are now carried out online. This impact is also felt by coffee shop business actors in the Wonocolo sub-district, Surabaya. Judging from the reduced sales turnover and the lack of visitors, some of them have to close temporarily, some have to close permanently. This research was conducted with a qualitative descriptive method through the research object of a coffee shop located in the Wonocolo district of Surabaya, the data collection technique used interviews with informants and observations to one of the coffee shops in the Wonocolo district of Surabaya.
Keywords: Covid-19 Pandemic, PPKM, Coffee Shop Businesses
Pengaruh Popularitas, Kualitas Argumen, Daya Tarik Pada Unggahan @Dr.Ziee di Tiktok Terhadap Kepercayaan, Sikap dan Niat Beli
Authors: Faradina Nisa Andini , Hartini Sri , Khairunnisa Shafira 
Published: November 2023

This research aims to determine the effect of popularity, quality of argument, attractiveness of @dr.ziee skincare product recommendation post on TikTok on trust, attitude and purchase intention by using cue utilization theory. This study uses a quantitative approach with the analytical technique used is partial least square with 200 respondents using TikTok who have a minimum age of 16 years and skincare users. The dependent variable used is the popularity of the post, the quality of the argument and the attractiveness of the post. The independent variable is purchase intention with the mediating variables are beliefs and attitudes. The results show that the popularity, argument quality and attractiveness of the post have a significant positive impact on trust which means that users take advantage of the popularity post, argumentation quality and attractiveness of the post to build on recommendation posts on social media. The attractiveness of post with short videos complements previous research using photo media, where the attractiveness of short videos can make consumers understand product information better because it is an information-rich medium compared to photos, thus affecting trust in recommendation posts. Trust in the recommendation post also affects attitudes and purchase intentions positively and significantly which is in accordance with previous research.
Keywords: : Post Popularity; Argument Quality; Post Attractiveness; Trust; Attitude; Purchase Intention; Cue Utilization Theory
Exploring porphyrins induced carbon nanocone TM-PICNC (TM = Sc2+, Ti2+, V2+, Cr2+, Fe2+, Co2+, Ni2+, Cu2+, and Zn2+) as a highly sensitive sensor for CO2 gas detection in presence O2 and H2O molecules: a computational study
Authors: Wu Guizhou , Arshadi Sattar , Pouralimardan Omid , Abbasi Vahideh , Vessally Esmail 
Published: November 2023

This study investigated the adsorption of CO2 molecules on transition metal ions (TM) porphyrins induced carbon nanocone (TM-PICNC) (TM = Sc2+, Ti2+, V2+, Cr2+, Fe2+, Co2+, Ni2+, Cu2+, and Zn2+) using density functional theory (DFT) to determine the stabilities, energetic, structural, and electronic properties. The results showed that the CO2 molecule is adsorbed on TM-PICNC with adsorption energies ranging from 0.03 to −12.12 kcal/mol. The weak interactions of CO2 gas with Cr, Ni, Cu, and Zn-PICNC were observed, while strong adsorption was found on Sc, Ti, and V-PICNC. The Ti, V, and Cr-PCNC structures were shown to have a suitable energy gap (Eg) for sensing ability because of the effective and physical interaction between these structures and CO2 gas, leading to a short recovery time. DFT calculations also revealed that V-PCNC had a high %ΔEg (about %56.79) and hence high sensitivity to CO2 gas, making it a promising candidate for having good sensing ability to CO2 gas in presence of O2 and H2O gas.
Early outcome of endoscopic mitral valve surgery in elderly patients: a high-volume single center experience
Authors: Pausch Jonas , Bhadra Oliver D. , Hua Xiaoqin , Stolfa Philipp , Kuhlmann Carolin , Voß Mirko , Girdauskas Evaldas , Reichenspurner Hermann , Conradi Lenard 
Published: November 2023

IntroductionDespite increasing use of transcatheter approaches, endoscopic mitral valve surgery (MVS) remains an established option for treatment of mitral regurgitation (MR). Nevertheless, as perioperative risk increases with age, outcome of endoscopic MVS in elderly patients is uncertain.MethodsWe retrospectively analyzed 756 consecutive patients with MR ≥2, who underwent minimally-invasive MVS at our institution between 2016 and 2022. Patients were stratified by age ≥75 (elderly-group; n = 91) or &lt;75 years (control-group; n = 665). All patients received endoscopic MVS via right anterolateral minithoracotomy with non-rib spreading soft tissue retraction and 3D-camera visualization.ResultsOverall surgical risk was increased in the elderly-group (median age of 77 (76–80) years vs. 58 (51–67) years, p &lt; 0.001) with STS-PROM Scores of 1.9% vs. 0.4% (p &lt; 0.001) and increased prevalence of hypertension, diabetes, coronary artery disease and atrial fibrillation (AFib). Elderly patients were also more symptomatic (NYHA class III 45.7% vs. 29.8%; p = 0.002). Axillo-femoral perfusion was more frequently used in the elderly-group (27.5% vs. 4.2%; p &lt; 0.001). Cross-clamp and cardiopulmonary bypass times were similar. Rate of MV repair was 85.7% vs. 93.8% (p = 0.005). Closure of the left atrial appendage was more frequently performed in the elderly-group (45.1% vs. 23.9%; p &lt; 0.001), whereas rate of concomitant tricuspid valve repair was similar (11.0% vs. 8.9%; p = 0.511). Postoperative complications including perioperative hemodialysis (3.3% vs. 2.9%; p = 0.739), low cardiac output (5.3% vs. 3.8%; p = 0.393), perioperative stroke (1.1% vs. 0.15%; p = 0.224) and myocardial infarction (0% vs. 0.15%) were favorably low in both groups. Acute mortality at 30 days was 2.2% vs. 0.4% (p = 0.112).ConclusionDespite increased prevalence of outcome-relevant comorbidities and surgical risk, perioperative outcome of patients aged ≥75 years undergoing endoscopic MVS is favorable. Therefore, endoscopic MVS is a valuable therapeutic option for selected elderly patients and should be taken in consideration during routine heart-team discussion.
Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis
Authors: Al Othaim Ayoub , Al-Hawary Sulieman Ibraheem Shelash , Alsaab Hashem O. , Almalki Sami G. , Najm Mazin A. A. , Hjazi Ahmed , Alsalamy Ali , Firras Almulla Abbas , Alizadeh Hamzeh 
Published: November 2023

Background: An increasing number of studies have suggested the relationship between single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes and gastric cancer (GC) susceptibility; however, the available evidence is contradictory. This meta-analysis aimed to comprehensively evaluate whether the SNPs within the TLR family are related to GC development.Methods: PubMed, Scopus, and China National Knowledge Infrastructure (CNKI) were systematically searched up to May 2023 to obtain the pertinent publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were applied to examine the associations using the random-effects model.Results: A total of 45 studies with 25,831 participants (cases: 11,308; controls: 14,523) examining the relation of 18 different SNPs in the TLR family to GC were analyzed. Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models. No significant association was detected for TLR-2-196 to -174de (Delta22), TLR-2 rs3804100, TLR-4 rs11536889, TLR-4 rs11536878, TLR-4 rs2770150, TLR-4 rs10116253, TLR-4 rs1927911, TLR-4 rs10983755, TLR-4 rs10759932, TLR-4 rs1927914, and TLR-10 rs10004195.Conclusion: These findings indicate that variations in TLR-4, TLR-5, and TLR-9 genes were found to be potential risk factors for GC.
Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction
Authors: Jorge Salomão Dória , Chi Young-In , Mazaba Jose Lizarraga , Haque Neshatul , Wagenknecht Jessica , Smith Brian C. , Volkman Brian F. , Mathison Angela J. , Lomberk Gwen , Zimmermann Michael T. , Urrutia Raul 
Published: November 2023

Introduction: Kleefstra Syndrome type 2 (KLEFS-2) is a genetic, neurodevelopmental disorder characterized by intellectual disability, infantile hypotonia, severe expressive language delay, and characteristic facial appearance, with a spectrum of other distinct clinical manifestations. Pathogenic mutations in the epigenetic modifier type 2 lysine methyltransferase KMT2C have been identified to be causative in KLEFS-2 individuals.Methods: This work reports a translational genomic study that applies a multidimensional computational approach for deep variant phenotyping, combining conventional genomic analyses, advanced protein bioinformatics, computational biophysics, biochemistry, and biostatistics-based modeling. We use standard variant annotation, paralog annotation analyses, molecular mechanics, and molecular dynamics simulations to evaluate damaging scores and provide potential mechanisms underlying KMT2C variant dysfunction.Results: We integrated data derived from the structure and dynamics of KMT2C to classify variants into SV (Structural Variant), DV (Dynamic Variant), SDV (Structural and Dynamic Variant), and VUS (Variant of Uncertain Significance). When compared with controls, these variants show values reflecting alterations in molecular fitness in both structure and dynamics.Discussion: We demonstrate that our 3D models for KMT2C variants suggest distinct mechanisms that lead to their imbalance and are not predictable from sequence alone. Thus, the missense variants studied here cause destabilizing effects on KMT2C function by different biophysical and biochemical mechanisms which we adeptly describe. This new knowledge extends our understanding of how variations in the KMT2C gene cause the dysfunction of its methyltransferase enzyme product, thereby bearing significant biomedical relevance for carriers of KLEFS2-associated genomic mutations.
Altered intestinal microbiota enhances adenoid hypertrophy by disrupting the immune balance
Authors: Liu Wenxin , Jiang Huier , Liu Xiling , Zheng Yue , Liu Yanan , Pan Fen , Yu Fangyuan , Li Zhi , Gu Meizhen , Du Qingqing , Li Xiaoyan , Zhang Hong , Han Dingding 
Published: November 2023

IntroductionAdenoid hypertrophy (AH) is a common upper respiratory disorder in children. Disturbances of gut microbiota have been implicated in AH. However, the interplay of alteration of gut microbiome and enlarged adenoids remains elusive.Methods119 AH children and 100 healthy controls were recruited, and microbiome profiling of fecal samples in participants was performed using 16S rRNA gene sequencing. Fecal microbiome transplantation (FMT) was conducted to verify the effects of gut microbiota on immune response in mice.ResultsIn AH individuals, only a slight decrease of diversity in bacterial community was found, while significant changes of microbial composition were observed between these two groups. Compared with HCs, decreased abundances of Akkermansia, Oscillospiraceae and Eubacterium coprostanoligenes genera and increased abundances of Bacteroides, Faecalibacterium, Ruminococcus gnavus genera were revealed in AH patients. The abundance of Bacteroides remained stable with age in AH children. Notably, a microbial marker panel of 8 OTUs were identified, which discriminated AH from HC individuals with an area under the curve (AUC) of 0.9851 in the discovery set, and verified in the geographically different validation set, achieving an AUC of 0.9782. Furthermore, transfer of mice with fecal microbiota from AH patients dramatically reduced the proportion of Treg subsets within peripheral blood and nasal-associated lymphoid tissue (NALT) and promoted the expansion of Th2 cells in NALT.ConclusionThese findings highlight the effect of the altered gut microbiota in the AH pathogenesis.
Association of retinal vessel pathology and brain atrophy in relapsing-remitting multiple sclerosis
Authors: Romahn Eva Feodora , Wiltgen Tun , Bussas Matthias , Aly Lilian , Wicklein Rebecca , Noll Christina , Berthele Achim , Dehmelt Vera , Mardin Christian , Zimmer Claus , Korn Thomas , Hemmer Bernhard , Kirschke Jan S. , Mühlau Mark , Knier Benjamin 
Published: November 2023

BackgroundOptical coherence tomography angiography (OCTA) allows non-invasive assessment of retinal vessel structures. Thinning and loss of retinal vessels is evident in eyes of patients with multiple sclerosis (MS) and might be associated with a proinflammatory disease phenotype and worse prognosis. We investigated whether changes of the retinal vasculature are linked to brain atrophy and disability in MS.Material and methodsThis study includes one longitudinal observational cohort (n=79) of patients with relapsing-remitting MS. Patients underwent annual assessment of the expanded disability status scale (EDSS), timed 25-foot walk, symbol digit modalities test (SDMT), retinal optical coherence tomography (OCT), OCTA, and brain MRI during a follow-up duration of at least 20 months. We investigated intra-individual associations between changes in the retinal architecture, vasculature, brain atrophy and disability. Eyes with a history of optic neuritis (ON) were excluded.ResultsWe included 79 patients with a median disease duration of 12 (interquartile range 2 - 49) months and a median EDSS of 1.0 (0 - 2.0). Longitudinal retinal axonal and ganglion cell loss were linked to grey matter atrophy, cortical atrophy, and volume loss of the putamen. We observed an association between vessel loss of the superficial vascular complex (SVC) and both grey and white matter atrophy. Both observations were independent of retinal ganglion cell loss. Moreover, patients with worsening of the EDSS and SDMT revealed a pronounced longitudinal rarefication of the SVC and the deep vascular complex.DiscussionON-independent narrowing of the retinal vasculature might be linked to brain atrophy and disability in MS. Our findings suggest that retinal OCTA might be a new tool for monitoring neurodegeneration during MS.
A high-fat diet protects C57BL/6 mice from Plasmodium berghei ANKA infection in an experimental malaria study
Authors: Soares Sara Malaguti Andrade , Gualberto Ana Cristina Moura , da Costa Augusto Cesar , Gonçalves Diego Assis , Gameiro Jacy 
Published: November 2023

IntroductionIt is well known that dietary changes have a significant impact on the immune system, and modifications in lipid balance may contribute to disease progression in several cases. Malaria is still a major global health concern, and the development of the disease has already been linked to the host’s nutritional status, so it’s critical to understand how environmental factors, such as dietary variations, can influence the outcome of infection. We therefore investigated the effect of a short-term diet in a murine model of experimental cerebral malaria.MethodsFor this, male C57BL/6 mice were fed a high fat diet containing 60% of the calories from lipids for 5 days. Following this period, the animals were infected with Plasmodium berghei ANKA, and parasitemia, survival, and neurological scores were compared. Considering that one of the first elimination routes of the intracellular parasite is oxidative stress, the antioxidant N-acetylcysteine was administered to assess whether the protection would be reversed.Results and discussionAnimals fed a hyperlipidic diet reacted the same way to infection even after NAC administration. Unlike the control group, which died after eight days of infection with roughly 7% parasitized red blood cells, the hyperlipidic diet group was resistant to infection, with no clinical signs and no increase in blood parasitemia. Several proinflammatory cytokines such as TNF-α IFN-γ and IL-6 were increased in the spleen of both infected groups, regardless of their diet. The provision of a high-fat diet to mice for as little as 5 days completely prevents Plasmodium berghei ANKA infection in C57BL/6 mice, while the treatment of an antioxidant failed to reverse the parasite protection.
Presence of tissue schistosomiasis in KwaZulu-Natal, South Africa: a retrospective histopathologic review
Authors: Mwazha Absalom , Nhlonzi Gamalenkosi Bonginkosi , Kjetland Eyrun Floerecke 
Published: November 2023

BackgroundSchistosomiasis affects many parts of the human body including those not usually accessible during routine clinical follow-up. We investigated the presence of schistosomiasis in routine tissue specimens sent to the only public histopathology laboratory in KwaZulu-Natal, South Africa.MethodsThe catchment area for the Department of Anatomical Pathology constitutes 11 million people in 10 districts. We retrospectively reviewed all the histopathology reports for occurrence of schistosomiasis between 1 January 2015 and 30 June 2020.ResultsSchistosomiasis was identified in the appendix, uterine cervix, urinary bladder, lung, liver, fallopian tubes and prostate. During the study period, 725 cases had a diagnosis of schistosomiasis confirmed on histopathology, which equals 0.3% of the total number of specimens sent to the laboratory. Female genital schistosomiasis represented 49.1% (356/725) of the schistosomiasis cases of which 25.1% (182) were from the uterine cervix and 24% (174) from the fallopian tubes. The appendix had 39.7% (289) of all the cases of schistosomiasis. Other organs were urinary bladder (4.4%, 32), lung (3.2%, 23) and liver (2.6%, 19). There were two cases of schistosomiasis in the prostate and four cases in the anorectal region. The main three indications for taking biopsies were acute appendicitis, cervical intraepithelial neoplasia, and sterilization. Majority of the schistosomiasis cases (312) were from eThekwini/Durban metropolitan district, however this represented only 1.2% (312/25 111) of the specimens received from eThekwini/Durban. The districts with the highest percentage positive cases were uMkhanyakude (43/965, 4.5%), followed by Ugu (129/5 251, 2.6%), and King Cetshwayo districts (132/5 360, 2.5%).ConclusionClinicians in the KwaZulu-Natal public health sector hospitals did not suspect schistosomiasis when they submitted patient samples for histopathological investigations. The study indicates the prevalence and the diversity of the body organs affected by schistosomiasis.
Development and validation of a nomogram for predicting low birth weight among pregnant women who had antenatal care visits at Debre Markos Comprehensive and Specialized Hospital, Ethiopia
Authors: Fente Bezawit Melak , Tesema Getayeneh Antehunegn , Gudayu Temesgen Worku , Asaye Mengstu Melkamu 
Published: November 2023

BackgroundBirth weight is a crucial factor linked to a newborn’s survival and can also affect their future health, growth, and development. Earlier, researchers focused on exploring maternal and fetal factors contributing to low birth weight. However, in recent years, there has been a shift toward effectively predicting low birth weight by utilizing a combination of variables. This study aims to develop and validate a nomogram for predicting low birth weight in Ethiopia.MethodsA retrospective follow-up study was conducted, and a total of 1,120 pregnant women were included. Client charts were selected using a simple random sampling technique. Data were extracted using a structured checklist prepared on the KoboToolbox (Cambridge, Massachusetts in the United States) and exported to STATA version 14 (Computing Resource Center in California) and R version 4.2.2 (University of Auckland, New Zealand) for data management and analysis. A nomogram was developed based on a binary logistic model, and its performance was assessed by discrimination power and calibration. Internal validation was performed using bootstrapping. To evaluate the clinical impact, decision curve analysis was applied.ResultsThe nomogram included gestational age, hemoglobin, primigravida, unplanned pregnancy, and preeclampsia. The AUROC of the predicted nomogram was 84.3%, and internal validation was 80.1%. The calibration plot indicated that the nomogram was well calibrated. The model was found to have clinical benefit.ConclusionThe nomogram demonstrates strong discrimination performance and can predict low birth weight clinically. As a result, it can be used in clinical practice, which will help clinicians in making quick and personalized predictions simply and rapidly, enabling the early identification and medical intervention. For broader applicability, the nomogram must be externally validated.