bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Relationships and Caregiver Burden: A Longitudinal Study of Caregivers for Advanced Cancer Patients
Authors: Sun Rongjun , Francis Linda E 
Published: October 2023

Abstract

Objectives
In a longitudinal design, this study investigates the role of the quality of relationships in the well-being of caregivers for a family member with advanced cancer, specifically, the quality of relations among family members and the caregiver’s commitment to caregiving. Following the stress process model, good quality of relations and caregiver’s high commitment should be resources mitigating caregiver burden, even though overinvestment in the caregiver role may lead to the opposite outcome.

Methods
Data were drawn from a longitudinal study of 336 caregivers of advanced cancer patients in an urban community, who were interviewed shortly after patient diagnosis and again 3 months later. Caregiver burden is measured by 4 subscales (17 items) of the Caregiver Reaction Assessment. We used a random-effect model to investigate the association between caregiver burden and the 2 focused contributing factors—caregiver commitment and family relationship quality—when other covariates were controlled. A fixed-effect model then examines the association between the changes in caregiver burden and related time-varying factors, including caregiver commitment, when family relationship quality was used as a moderator.

Results
Both the random and fixed-effect models consistently show that a cancer caregiver’s positive commitment to the patient reduces caregiver burden, and family relationship quality provides an overall moderating influence that reduces the felt burden.

Discussion
The quality of relations between the caregiver and patient and with others in the family network is critical in understanding caregiver burden in advanced cancer and should be viewed as part of long-term family dynamics.
Community-Engaged Research With Latino Dementia Caregivers: Overcoming Challenges in Community Advisory Board Development
Authors: Quiñones Maria M , Sörensen Silvia , Hepburn Kenneth , Capellan Jahaira , Heffner Kathi L 
Published: October 2023

Abstract

Background and Objectives
Latinos caring for a person with Alzheimer’s disease and related dementias (ADRD) have the highest prevalence of caregiving. Yet, they are less likely to benefit from evidence-based interventions given their continued underrepresentation in ADRD-related research. Community advisory boards (CABs) have the potential to address barriers to research for underrepresented communities; however, there are complexities to establishing and sustaining CABs. This article describes how our work addressed challenges in CABs related to unbalanced power relations, language barriers, the value of time, and low research knowledge and health literacy.

Research Design and Methods
Nine Latino CAB members, including older Latino caregivers, were trained in a comprehensive program designed to increase knowledge about health research methods and ethics, cognitive health, and cultural adaptation methods. Members completed pre- and post-training measures of Alzheimer’s disease knowledge, attitudes, and beliefs toward research, and a satisfaction survey.

Results
Results from the satisfaction questionnaire indicated that the program was well received. CAB members increased their knowledge regarding the management of behavioral and psychological symptoms of dementia and dementia-associated risk factors and treatment. Positive changes in members’ attitudes toward research included increased willingness to participate in trials and subject protection measures.

Discussion and Implications
Formalized training in research conduct and ethics and health literacy is a promising strategy to reduce challenges in establishing and maintaining CABs and can also optimize CAB impact to address gaps in older Latino ADRD caregiving research.
Are Depression and Anxiety Underdiagnosed in Socially Vulnerable Patients With Inflammatory Bowel Disease?
Authors: Sheehan Jessica L , Jordan Ariel A , Newman Kira L , Johnson Laura A , Eloubeidi Dala , Cohen-Mekelburg Shirley , Berinstein Jeffrey A , Tipirneni Renuka , Higgins Peter D R 
Published: October 2023

Abstract

Introduction
Depression and anxiety are highly prevalent among individuals with inflammatory bowel disease (IBD); however, little is understood about how social determinants of health (SDOH) may impact mental health diagnoses in this population. The social vulnerability index (SVI) is a publicly available tool that can be used to study SDOH in IBD patients.

Methods
Home addresses from a retrospective cohort of IBD patients at a single center were used to geocode patients to their individual census tract and corresponding SVI. We used multivariable logistic regression to examine the relationship between SVI and comorbid mental health diagnoses in patients with IBD. Secondarily, data from standardized health questionnaires were then used to determine if patients were adequately screened for depression and anxiety.

Results
In all, 9644 patients were included; 18% had a diagnosis of depression, 21% anxiety, and 32% had a composite of “any mental health diagnosis.” Depression (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.02-1.56) but not anxiety (OR, 0.87; 95% CI, 0.71-1.06) nor “any mental health diagnosis” (OR, 1.09; 95% CI, 0.92-1.30) was associated with higher levels of social vulnerability. However, overall rates of screening for depression and anxiety were low (15% and 8%, respectively), with the lowest screening rates among the most socially vulnerable (depression 8.2%, anxiety 6.3%).

Conclusions
Disparities in the diagnoses of depression and anxiety for socially vulnerable patients with IBD exist. Awareness of these inequities is the first step toward developing interventions to improve mental health screening, eliminate barriers and bias, and promote referrals for appropriate mental health management.
NLRP3 inflammasome activation in sensory neurons promotes chronic inflammatory and osteoarthritis pain
Authors: Silva Santos Ribeiro Patrícia , Willemen Hanneke L D M , Versteeg Sabine , Martin Gil Christian , Eijkelkamp Niels 
Published: October 2023

Summary
Pain is one of the most debilitating symptoms in rheumatic diseases. Pain often persists after total knee replacement in osteoarthritis, or when inflammation is minimal/absent in rheumatoid arthritis. This suggests that pain transitions to a chronic state independent of the original damage/inflammation. Mitochondrial dysfunction in the nervous system promotes chronic pain and is linked to NLRP3 inflammasome activation. Therefore, we investigated the role of mitochondrial dysfunction and NLRP3 inflammasome activation in the transition from acute to persistent inflammation-induced nociplastic pain and in persistent monoiodoacetate-induced osteoarthritis pain. Intraplantar injection of carrageenan in mice induced transient inflammatory pain that resolved within 7 days. A subsequent intraplantar PGE2 injection induced persistent mechanical hypersensitivity, while in naive mice it resolved within one day. Thus, this initial transient inflammation induced maladaptive nociceptor neuroplasticity, so-called hyperalgesic priming. At Day 7, when mice were primed, expression of NLRP3 inflammasome pathway components was increased, and dorsal root ganglia (DRG) neurons displayed signs of activated NLRP3 inflammasome. Inhibition of NLRP3 inflammasome with MCC950 prevented the transition from acute to chronic pain in this hyperalgesic priming model. In mice with persistent monoiodoacetate-induced osteoarthritis pain, DRG neurons displayed signs of mitochondrial oxidative stress and NLRP3 inflammasome activation. Blocking NLRP3 inflammasome activity attenuated established osteoarthritis pain. In males, NLPR3 inhibition had longer-lasting effects than in females. Overall, these data suggest that NLRP3 inflammasome activation in sensory neurons, potentially caused by neuronal oxidative stress, promotes development of persistent inflammatory and osteoarthritis pain. Therefore, targeting NLRP3 inflammasome pathway may be a promising approach to treat chronic pain.
The Gendered Peace Premium
Authors: Blair Christopher W , Schwartz Joshua A 
Published: October 2023

AbstractThe adage that “only Nixon could go to China” suggests hawkish leaders face fewer domestic political barriers to pursuing conciliation with foreign adversaries. Since hawks are viewed as less ideologically predisposed to peace than doves, their efforts at rapprochement are more likely to be perceived as in the national interest. We explore how this conventional wisdom intersects with prominent gender stereotypes about women’s role in national security. Do gender stereotypes that women are inclined toward peace make it more difficult for women leaders to pursue conciliation? In a series of survey experiments, we find evidence of a gendered peace premium—a penalty women leaders face for pursuing peace. When women leaders seek rapprochement with foreign adversaries, they are perceived as acting “according to type.” Consequently, women’s conciliatory policy proposals are viewed as less likely to be in the national interest than identical policies pursued by male leaders. Partisanship dynamics significantly moderate the gendered peace premium, and policy success can attenuate women leaders’ disadvantage. While this discriminatory dynamic does not make it impossible for women leaders to seek and achieve peace, it does make it more difficult and politically costly than some perspectives assume.
Comparison of Continuous Sedatives in the Burn ICU on Delirium and Coma
Authors: Falksen Jessica A , Young Sierra R , Lee Jin A 
Published: October 2023

Abstract
Lighter sedation targets over the past decade have resulted in improved outcomes for critically ill populations. Although guidelines exist for the general ICU population, these recommendations often exclude the burn population. The purpose of this study is to assess the impact of the initial continuous sedative on coma- and delirium-free days in critically ill patients with burns. This retrospective cohort study evaluated adult patients admitted to a burn intensive care unit at an academic medical center between January 2010 and September 2019. Patients were enrolled into 3 groups based on the depth of initial continuous sedation received (deep, light, or analgosedation). Intubated patients were randomly assessed for inclusion from the National V6 Burn Registry. Patients were included if they received a continuous sedative infusion for at least 48 h. A total of 107 patients were included in the study with 36, 41, and 30 patients receiving deep, light, and analgosedation, respectively. The primary outcome of coma- and delirium-free days was significantly different between sedation types with the most days free in analgosedation and the fewest in deep sedation (8 versus 3 days; P = 0.024). The composite primary outcome was divided into secondary outcomes of coma-free days and delirium-free days, with coma-free days being different (P = 0.00008). Other secondary outcomes of length of stay in the intensive care unit and hospital, time on mechanical ventilation, and survival to discharge were not statistically significant; however, a trend toward higher mortality in deep sedation was noted.
Dose–responses of seven species of cerambycid beetles to synthesized pheromones in field experiments
Authors: Grommes Anna C , Millar Jocelyn G , Hanks Lawrence M 
Published: October 2023

Abstract
Adult male cerambycid beetles of the subfamilies Cerambycinae and Lamiinae emit aggregation-sex pheromones that attract both sexes, and these chemicals can be utilized for quarantine surveillance for related exotic species which produce the same or similar pheromones. Here, we assess how attraction of 7 cerambycid species to pheromone-baited traps was influenced by the release rates of synthesized pheromones from polyethylene sachet emitters. Compounds tested included racemic 3-hydroxyhexan-2-one, the (R)-enantiomer of which is the sole or major pheromone component of numerous cerambycine species, and 2 compounds that are pheromone components of many lamiine species: (E)-6,10-dimethyl-5,9-undecadien-2-yl acetate (fuscumol acetate) and 6-methylhept-5-en-2-ol (sulcatol). We confirmed release rates of these compounds could be manipulated by varying the doses loaded into emitters. Various doses and concentrations, ranging from very dilute to the neat compounds, were then tested in field trials. Several species were most strongly attracted to the highest dose of a tested compound, one species to an intermediate dose, while another species was equally attracted regardless of dose. Our results demonstrate the importance of characterizing dose–response relationships for cerambycid species targeted by pheromone-based trapping.
Hilling as a cultural control strategy for soybean gall midge (Diptera: Cecidomyiidae)
Authors: McMechan Anthony Justin , Schroeder de Souza Joana , Umezu Natasha , Gupta Pragya , Inveninato Carmona Gabriela 
Published: October 2023

Abstract
Soybean gall midge, Resseliella maxima Gagné, was recently identified as a new species causing significant injury to soybean and is currently found in 164 counties across 7 midwestern states (NE, IA, SD, MN, MO, ND, and KS). Infestation of soybean begins in late spring, when adults emerge from last year’s soybean field. Infestation of a new soybean crop depends on the presence of fissures which start to form at the base of the soybean plant around the V2 stage. Field observations indicate that these fissures are only present below the cotyledonary nodes or in the area within 3–5 cm above the soil surface. To determine the importance of these fissures for R. maxima infestation and plant injury, hilling or the movement of the soil to cover the base of soybean plants at the V2–V3 stage was compared with the standard practice (no-hilling). Field studies were conducted at 3 sites in east-central Nebraska during the 2021 growing season. The results showed a significant reduction in the frequency of infested plants, larval number per plant, and plant injury for hilled compared to no-hill treatment. This reduction in the presence of larvae and plant injury corresponded with a significantly greater yield for hilled compared to the no-hill treatment. These results highlight the importance of fissures on soybean for R. maxima adult infestation as well as the potential for hilling to be used as a management strategy for R. maxima.
Constructive aspects of Riemann’s permutation theorem for series
Authors: Berger J , Bridges Douglas , Diener Hannes , Schwichtenberg Helmet 
Published: October 2023

Abstract
The notions of permutable and weak-permutable convergence of a series $\sum _{n=1}^{\infty }a_{n}$ of real numbers are introduced. Classically, these two notions are equivalent, and, by Riemann’s two main theorems on the convergence of series, a convergent series is permutably convergent if and only if it is absolutely convergent. Working within Bishop-style constructive mathematics, we prove that Ishihara’s principle BD- $\mathbb {N}$ implies that every permutably convergent series is absolutely convergent. Since there are models of constructive mathematics in which the Riemann permutation theorem for series holds but BD- $\mathbb{N}$ does not, the best we can hope for as a partial converse to our first theorem is that the absolute convergence of series with a permutability property classically equivalent to that of Riemann implies BD- $\mathbb {N}$ . We show that this is the case when the property is weak-permutable convergence.
Epistemic injustice in educational policy: an account of structural contributory injustice
Authors: Bogia Megan L 
Published: October 2023

Abstract
In this paper, I introduce a special case of epistemic injustice that I call ‘structural contributory injustice’. This conception aims to capture some dimensions of how policy—separately from individual agential interactions—can generate epistemic injustice at a group level. I first locate the case within Kristie Dotson’s original conception of contributory injustice. I then consider one potential case of structural contributory injustice—namely, the policy problem of significant financial risk burden on students considering university in the USA. Finally, I consider potential policy reforms in response to this injustice.
Trends in anti-neuropathic medications turnover in Iraq
Authors: Al-Shammaa Zainab M , Aladul Mohammed I , Essa Narmin S 
Published: October 2023

Abstract

Objectives
Neuropathic pain (NP) is a type of chronic pain. Numerous diseases and/or lesions are associated with the development of NP, and diabetes mellitus is the most prevalent cause. Several classes of medications were recommended and/or approved as anti-neuropathic medications. This study aimed to examine the trends in the turnover of anti-neuropathic medications in Iraq.

Methods
This was a retrospective analysis of the turnover of selected anti-neuropathic medications in the Iraqi market derived from Advanced Marketing Statistics between 2017 and 2021. The sales units were converted to defined daily doses. Regression analysis and correlation analysis were used to compare the turnover of the medications.

Key findings
The overall volume of turnover of anti-neuropathic medications increased between 2017 and 2021. The anti-neuropathic market domination was shifted from carbamazepine to pregabalin, in which the average increase in pregabalin turnover of 60% [95% CI (confidence interval) 37.6–82.5] quarterly to achieve 42% of the market share (highest sales) by 2021. The overall expenditure on anti-neuropathic medications increased steadily over the study period.

Conclusions
The market of anti-neuropathic medications’ domination was shifted from the older antiepileptic drug (AED) (carbamazepine) to the newer AED (pregabalin). The availability and affordability of less expensive generic versions of these agents, together with the better safety profiles of the newer agents were the main driver for this shift. This indeed allowed Iraqi physicians to adhere to the latest international guidelines.
Causal inference with a functional outcome
Authors: Ecker Kreske , de Luna Xavier , Schelin Lina 
Published: October 2023

Abstract
This article presents methods to study the causal effect of a binary treatment on a functional outcome with observational data. We define a Functional Average Treatment Effect (FATE) and develop an outcome regression estimator. We show how to obtain valid inference on the FATE using simultaneous confidence bands, which cover the FATE with a given probability over the entire domain. Simulation experiments illustrate how the simultaneous confidence bands take the multiple comparison problem into account. Finally, we use the methods to infer the effect of early adult location on subsequent income development for one Swedish birth cohort.
Using CHIRON spectroscopy to test the hypothesis of a precessing orbit for the WN4 star EZ CMa
Authors: Barclay Krister D G , Rosu Sophie , Richardson Noel D , Chené André-Nicolas , St-Louis Nicole , Ignace Richard , Moffat Anthony F J 
Published: October 2023

ABSTRACT
The bright WN4 star EZ CMa exhibits a 3.77 d periodicity in photometry, spectroscopy, and polarimetry, but the variations in the measurements are not strictly phase-locked, exhibiting changes in reference times, amplitudes, and the shape of the variability happening over times as short as a few weeks. Recently, 137 d of contiguous, variable photometry from BRITE-constellation was interpreted as caused either by large-scale dense wind structures modulated by rotation, or by a fast-precessing binary having a slightly shorter 3.626 d orbital period and a fast apsidal motion rate of $1315^\circ \, \text{yr}^{-1}$. We aim at testing the latter hypothesis through analysis of spectroscopy and focus on the N v λ 4945 line. We derive an orbital solution for the system and reject the 3.626 d period to represent the variations in the radial velocities of EZ CMa. An orbital solution with an orbital period of 3.77 d was obtained but at the cost of an extremely high and thus improbable apsidal motion rate. Our best orbital solution yields a period of 3.751 ± 0.001 d with no apsidal motion. We place our results in the context of other variability studies and system properties. While we cannot fully reject the precessing binary model, we find that the corotating interaction region (CIR) hypothesis is better supported by these and other data through qualitative models of CIRs.
Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism
Authors: Cosenza-Contreras Miguel , Schäfer Agnes , Sing Justin , Cook Lena , Stillger Maren N , Chen Chia-Yi , Villacorta Hidalgo Jose , Pinter Niko , Meyer Larissa , Werner Tilman , Bug Darleen , Haberl Zeno , Kübeck Oliver , Zhao Kai , Stei Susanne , Gafencu Anca Violeta , Ionita Radu , Brehar Felix M , Ferrer-Lozano Jaime , Ribas Gloria , Cerdá-Alberich Leo , Martí-Bonmatí Luis , Nimsky Christopher , Van Straaten Alexis , Biniossek Martin L , Föll Melanie , Cabezas-Wallscheid Nina , Büscher Jörg , Röst Hannes , Arnoux Armelle , Bartsch Jörg W , Schilling Oliver 
Published: October 2023

Abstract

Background
There is an urgent need to better understand the mechanisms associated with the development, progression, and onset of recurrence after initial surgery in glioblastoma (GBM). The use of integrative phenotype-focused -omics technologies such as proteomics and lipidomics provides an unbiased approach to explore the molecular evolution of the tumor and its associated environment.

Methods
We assembled a cohort of patient-matched initial (iGBM) and recurrent (rGBM) specimens of resected GBM. Proteome and metabolome composition were determined by mass spectrometry-based techniques. We performed neutrophil-GBM cell coculture experiments to evaluate the behavior of rGBM-enriched proteins in the tumor microenvironment. ELISA-based quantitation of candidate proteins was performed to test the association of their plasma concentrations in iGBM with the onset of recurrence.

Results
Proteomic profiles reflect increased immune cell infiltration and extracellular matrix reorganization in rGBM. ASAH1, SYMN, and GPNMB were highly enriched proteins in rGBM. Lipidomics indicates the downregulation of ceramides in rGBM. Cell analyses suggest a role for ASAH1 in neutrophils and its localization in extracellular traps. Plasma concentrations of ASAH1 and SYNM show an association with time to recurrence.

Conclusions
We describe the potential importance of ASAH1 in tumor progression and development of rGBM via metabolic rearrangement and showcase the feedback from the tumor microenvironment to plasma proteome profiles. We report the potential of ASAH1 and SYNM as plasma markers of rGBM progression. The published datasets can be considered as a resource for further functional and biomarker studies involving additional -omics technologies.