bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI SPK SAW UNTUK SELEKSI CALON DEBITUR ELEKTRONIK DAN FURNITUR DI PT. INTERYASA MITRA MANDIRI
Authors: Simbolon Cindy Victorya , Syafwan Havid , Christy Tika 
Published: December 2023

Abstrack: Currently, companies face problems in credit assessment methods which are still manual and take a long time to process data. Storing and searching archives is also a challenge, especially in matching up to date information. This research aims to develop a decision support system (DSS) to help PT. Interyasa Mitra Mandiri Kisaran Branch in assessing credit worthiness more efficiently. In this research, the simple and effective Simple Additive Weighting (SAW) method was used. This method will produce a SPK that explains the decision-making process graphically and considers various assessment criteria. By using the developed SPK, it is hoped that companies can increase efficiency in assessing credit worthiness, speed up data processing, and simplify information searches. An important implication of this research is the increased effectiveness and accuracy of credit worthiness assessments as well as the ease of decision making for PT. Interyasa Mitra Mandiri Kisaran Branch. With an integrated SPK, companies can optimize their processes and obtain relevant and timely information to support credit-related decisions. This will help companies make better decisions and reduce the time required for the credit worthiness assessment process. Keywords: decision support system; simple additive weighting; debtor; Pt. Interyasa Mitra Mandiri Abstrak : Saat ini, perusahaan menghadapi masalah dalam metode penilaian kredit yang masih manual dan memakan waktu lama dalam pengolahan data. Penyimpanan dan pencarian arsip juga menjadi tantangan, terutama dalam mencocokkan dengan informasi terbaru. Penelitian ini bertujuan mengembangkan sistem pendukung keputusan (SPK) untuk membantu PT. Interyasa Mitra Mandiri Cabang Kisaran dalam menilai kelayakan kredit dengan lebih efisien. Dalam penelitian ini, digunakan metode Simple Additive Weighting (SAW) yang sederhana dan efektif. Metode ini akan menghasilkan SPK yang menjelaskan proses pengambilan keputusan secara grafis dan mempertimbangkan berbagai kriteria penilaian. Dengan menggunakan SPK yang dikembangkan, diharapkan perusahaan dapat meningkatkan efisiensi dalam penilaian kelayakan kredit, mempercepat pengolahan data, dan menyederhanakan pencarian informasi. Implikasi penting dari penelitian ini adalah meningkatnya efektivitas dan akurasi penilaian kelayakan kredit serta kemudahan dalam pengambilan keputusan bagi PT. Interyasa Mitra Mandiri Cabang Kisaran. Dengan adanya SPK yang terintegrasi, perusahaan dapat mengoptimalkan prosesnya dan mendapatkan informasi relevan dan tepat waktu untuk mendukung keputusan terkait kredit. Hal ini akan membantu perusahaan dalam mengambil keputusan yang lebih baik dan mengurangi waktu yang dibutuhkan untuk proses penilaian kelayakan kredit. Kata Kunci: sistem pendukung keputusan; simple additive weighting; debitur; PT. Interyasa Mitra Mandiri
EFEKTIFITAS APLIKASI INSPEKTA DALAM PENINGKATAN BUDAYA K3 DI PLN ULP KISARAN
Authors: Sukoco Duwi Irpan , Puariesthaufani N Achmad 
Published: December 2023

Abstract: Enhancing Occupational Health and Safety (OHS) culture is of paramount importance in industrial settings, especially in energy sectors like PLN. Inspekta, an information technology-based application, has emerged as a potential solution to boost awareness and compliance with OHS practices at PLN ULP Kisaran. However, a comprehensive evaluation of this application's effectiveness is still necessary. This research aims to assess the effectiveness of the Inspekta Application in fostering an OHS culture at PLN ULP Kisaran. Utilizing a combined approach of literature review, questionnaire surveys, and statistical analysis, the study collected and analyzed relevant data.The research findings reveal that the implementation of the Inspekta Application has had a positive impact on elevating the OHS culture at PLN ULP Kisaran. Improved employee awareness regarding OHS aspects and more efficient incident reporting stand out as significant outcomes. Statistical analysis also indicates a positive correlation between the utilization of the Inspekta Application and the enhancement of the OHS culture. Based on the research insights, it can be concluded that the Inspekta Application is effective in enhancing the OHS culture at PLN ULP Kisaran. The integration of information technology through such applications holds the potential to mitigate workplace accident risks and foster a safer and healthier working environment. Keywords: inspekta; ohs culture; workplace safety Abstrak: Peningkatan budaya Keselamatan dan Kesehatan Kerja (K3) memiliki peran yang sangat penting dalam lingkungan industri, terutama di sektor energi seperti PT. Perusahaan Listrik Negara (PLN). Inspekta, sebuah aplikasi berbasis teknologi informasi, telah muncul sebagai solusi potensial untuk meningkatkan kesadaran dan kepatuhan terhadap budaya K3 di PT. PLN (Persero). Penelitian ini bertujuan untuk mengevaluasi efektivitas Aplikasi Inspekta dalam meningkatkan budaya K3 di PLN ULP Kisaran. Dengan pendekatan kombinasi studi literatur, survei kuesioner, dan analisis statistik, penelitian ini mengumpulkan dan menganalisis data yang relevan. Hasil penelitian baik dari kajian literature, observasi dan wawancara partisipatif menunjukkan bahwa Aplikasi Inspekta mendapat tanggapan positif yang signifikan dengan rata-rata indikator tanggapan diatas 50%, sehingga berdampak dalam memperkuat pemahaman budaya K3 di lingkungan kerja PLN. Penerapan Aplikasi Inspekta juga terbukti membantu dalam mengidentifikasi potensi bahaya K3, mendorong pelaporan bahaya, serta memungkinkan tindakan cepat setelah pelaporan melalui integrasi teknologi informasi guna mengurangi risiko kecelakaan kerja dan menciptakan lingkungan kerja yang lebih aman dan sehat. Kata Kunci: inspekta; budaya k3; keselamatan kerja
TÜRKİYE CUMHURİYETİ’NDE GERÇEKLEŞTİRİLEN İLK REFERANDUM: 1961 REFERANDUMU’NUN ULUSAL BASINA YANSIMASI
Authors: TAŞDELEN Esra , AYDOĞAN Erdal 
Published: December 2023

The first coup in the Republic of Türkiye was experienced on May 27, 1960. During the Republic period, the concept of referendum again entered the public agenda in this process. It is noteworthy that referendum, one of the most important tools of semi-direct democracy, was also used in the 1961 Constitution and the majority of the people participated in this process. This article aims to examine in detail the reflection of the 1961 Referendum, the first referendum in the history of the Republic of Türkiye, on the national press. It also evaluates the interpretation of the referendum process through cartoons and the effects of these cartoons on social consciousness. The content analysis method was used in the study. By examining materials such as news headlines, columns and cartoons, the media's approaches to the referendum process were tried to be presented from an objective perspective. In this way, the way the referendum was covered in the national press, the political atmosphere of the period and the perception created in the society were revealed through the media.
This study has revealed the historical context and importance of the 1961 Referendum. It has dealt with the political and social dynamics that led to the referendum, the people's preferences in the referendum, and the effects of the results on Turkish politics. In this context, it has analyzed in detail how the referendum results were received in the national press and how different media outlets gave meaning to these results. Examining the social reflections of the referendum process through cartoons has also constituted an important component of this study.
As a result, it has been determined that the reflections of the 1961 Referendum in the national press are an important source for understanding the political and social dynamics of the period. The press, one of the most important structural stones of the social and political equation, was used as the main source of the study. In this study, the 1961 referendum was examined as a whole by examining national newspapers. Thus, Türkiye's democratic processes, media relations and the impact of visual media were analyzed.
Supervised exercise training in patients with cancer during anthracycline-based chemotherapy to mitigate cardiotoxicity: a randomized-controlled-trial
Authors: Schneider Caroline , Ryffel Christoph , Stütz Laura , Rabaglio Manuela , Suter Thomas M. , Campbell Kristin L. , Eser Prisca , Wilhelm Matthias 
Published: December 2023

BackgroundExercise training (ET) has been shown to mitigate cardiotoxicity of anthracycline-based chemotherapies (AC) in animal models. Data from randomized controlled trials in patients with cancer are sparse.MethodsPatients with breast cancer or lymphoma receiving AC were recruited from four cancer centres and randomly assigned to 3 months supervised ET. Primary outcome was change in left ventricular global longitudinal strain (GLS) from baseline (before AC) to post AC (AC-end) compared between the EXduringAC group, who participated in an exercise intervention during AC including the provision of an activity tracker, and the control group EXpostAC, who received an activity tracker only. Secondary outcome parameters were changes in high sensitivity Troponin T (hsTnT), NT-pro-brain natriuretic peptide (NT-proBNP), peak oxygen consumption (peak VO2) and objectively measured physical activity (PA) during this same time-period. All assessments were repeated at a 12-week follow-up from AC-end, when also the EXpostAC group had completed the ET, that started after AC. In exploratory analyses, robust linear models were performed to assess the association of PA with changes in echocardiographic parameters and biomarkers of LV function.ResultsFifty-seven patients (median age 47 years; 95% women) were randomized to EXduringAC (n = 28) and EXpostAC (n = 29) group. At AC-end, GLS deteriorated in both study groups (albeit insignificantly) with 7.4% and 1.0% in EXduringAC (n = 18) and EXpostAC (n = 18), respectively, and hsTnT and NT-proBNP significantly increased in both groups, without difference between groups for any parameter. Change in peak VO2 (−1.0 and −1.1 ml/kg/min) at AC-end was also similar between groups as was duration of moderate-to-vigorous PA (MVPA) with a median of 33 [26, 47] min/day and 32 [21, 59] min/day in the EXduringAC and EXpostAC group, respectively. In the robust linear model including the pooled patient population, MVPA was significantly associated with a more negative GLS and lesser increase in hsTnT at AC-end.ConclusionIn this small scale RCT, supervised ET during AC was not superior to wearing a PA tracker to mitigate cardiotoxicity. The dose-response relationship between PA and cardioprotective effects during AC found in our and previous data supports the notion that PA should be recommended to patients undergoing AC.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT03850171.
Case report: Genetic analysis of a novel intronic inversion variant in the SPTB gene associated with hereditary spherocytosis
Authors: Xi Bixin , Liu Siying , Zhu Yongbing , Zhang Dedong , Zhang Yu , Liu Aiguo 
Published: December 2023

Background: Hereditary spherocytosis (HS) is a congenital haemolytic anaemia attributed to dysregulation or abnormal quantities of erythrocyte membrane proteins. Currently, the most common erythrocytic gene, spectrin β (SPTB), variants are located in exons and give rise to mRNA defects. However, the genetic characteristics and pathogenic mechanisms of SPTB intronic variants are not completely understood. This study aimed to analyse a rare intronic inversion variant in the SPTB gene associated with HS, and explore the impact of the variant on SPTB mRNA splicing.Method: The clinical manifestations of the patient were summarised and analysed for spherocytosis phenotype diagnosis. The pathogenic variant was identified in the proband using targeted next-generation and Sanger sequencing. RNA sequencing was performed to analyse whether SPTB gene splicing and expression were affected.Results: Targeted next-generation sequencing identified a novel disease-associated intronic inversion variant of the SPTB gene in the proband. The inversion variant was located between intron 19 and 20, and contained the entire exon 20 and partial sequences of adjacent introns. Sanger sequencing confirmed that the intronic inversion variant only appeared in the genome of the proband, not in his parents. RNA sequencing revealed that the variant could result in the skipping of exon 20 and reduced expression of SPTB mRNA.Conclusion: This study identifies a rare intronic inversion variant in the SPTB gene associated with hereditary spherocytosis. The pathogenic variant can lead to exon 20 skipping and decreased SPTB gene expression. This finding has not been previously reported in any literature. This study can expand the intronic variant spectrum of the SPTB gene, deepen our understanding of HS pathogenesis, and contribute to the genetic diagnosis and clinical management of patients.
Single-cell and bulk RNA sequencing analysis of B cell marker genes in TNBC TME landscape and immunotherapy
Authors: Zhao Fangrui , Zhao Chen , Xu Tangpeng , Lan Yanfang , Lin Huiqing , Wu Xiaofei , Li Xiangpan 
Published: December 2023

ObjectiveThis study amied to investigate the prognostic characteristics of triple negative breast cancer (TNBC) patients by analyzing B cell marker genes based on single-cell and bulk RNA sequencing.MethodsUtilizing single-cell sequencing data from TNBC patients, we examined tumor-associated B cell marker genes. Transcriptomic data from The Cancer Genome Atlas (TCGA) database were used as the foundation for predictive modeling. Independent validation set was conducted using the GSE58812 dataset. Immune cell infiltration into the tumor was assessed through various, including XCELL, TIMER, QUANTISEQ, CIBERSORT, CIBERSORT-ABS, and ssGSEA. The TIDE score was utilized to predict immunotherapy outcomes. Additional investigations were conducted on the immune checkpoint blockade gene, tumor mutational load, and the GSEA enrichment analysis.ResultsOur analysis encompassed 22,106 cells and 20,556 genes in cancerous tissue samples from four TNBC patients, resulting in the identification of 116 B cell marker genes. A B cell marker gene score (BCMG score) involving nine B cell marker genes (ZBP1, SEL1L3, CCND2, TNFRSF13C, HSPA6, PLPP5, CXCR4, GZMB, and CCDC50) was developed using TCGA transcriptomic data, revealing statistically significant differences in survival analysis (P&lt;0.05). Functional analysis demonstrated that marker genes were predominantly associated with immune-related pathways. Notably, substantial differences between the higher and lower- BCMG score groups were observed in terms of immune cell infiltration, immune cell activity, tumor mutational burden, TIDE score, and the expression of immune checkpoint blockade genes.ConclusionThis study has established a robust model based on B-cell marker genes in TNBC, which holds significant potential for predicting prognosis and response to immunotherapy in TNBC patients.
Efficacy of pegylated interferon α-2b plus entecavir therapy and predictors of treatment success in children with chronic hepatitis B
Authors: Huang Liang , Zhang Hong , Kang Xintong , Chen Zhu , Wang Lin , Zeng Yilan 
Published: December 2023

IntroductionInterferon therapy, used in the treatment of chronic hepatitis B (CHB), is one of the means by which patients can achieve a functional cure. Pegylated interferon is currently used in the treatment of CHB. There are two main types of pegylated interferon: α-2b and α-2a.MethodsThis study explored the efficacy, safety, and predictors of treatment response for α-2b plus entecavir among children in a real-world setting.ResultsThe study included 76 patients aged 3–18 years, all of whom were treated with interferon α-2b plus entecavir. The mean duration of treatment was 401.99 days, and 31.6% (24/76) of patients achieved HBsAg clearance. Competing risk model analyses showed that children with baseline HBsAg &lt;1500 IU/mL (subdistribution hazard ratio [sHR]=2.643, P=0.022) and a higher baseline alanine aminotransferase (ALT) level (sHR=1.005, P=0.000) had a higher probability of achieving HBsAg clearance during treatment. Conversely, children with a higher hepatitis B virus loading level (sHR=0.835, P=0.043) and age ≥10 years (sHR=0.243, P=0.002) had a lower probability of achieving HBsAg clearance during treatment. A decrease of &gt;1 log10 in HBsAg level (sHR=3.479, P=0.001) at 12 weeks of treatment was associated with a higher probability of achieving surface antigen clearance.DiscussionThese results indicated that interferon plus entecavir therapy is a promising means of achieving HBsAg clearance in children with CHB. Moreover, HBsAg, ALT, virus loading, and age are indicators of treatment success probability.
Altered dietary behaviour during pregnancy impacts systemic metabolic phenotypes
Authors: Rowley Charlotte E. , Lodge Samantha , Egan Siobhon , Itsiopoulos Catherine , Christophersen Claus T. , Silva Desiree , Kicic-Starcevich Elizabeth , O’Sullivan Therese A. , Wist Julien , Nicholson Jeremy , Frost Gary , Holmes Elaine , D’Vaz Nina 
Published: December 2023

RationaleEvidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and urine samples to assess differences between women who were stratified into high and low alignment to a MD throughout pregnancy and investigate the relationship of the diet to inflammatory markers.MethodsFrom the ORIGINS cohort, 51 pregnant women were stratified for persistent high and low alignment to a MD, based on validated MD questionnaires. 1H Nuclear Magnetic Resonance (NMR) spectroscopy was used to investigate the urine and serum metabolite profiles of these women at 36 weeks of pregnancy. The relationship between diet, metabolite profile and inflammatory status was investigated.ResultsThere were clear differences in both the food choice and metabolic profiles of women who self-reported concordance to a high (HMDA) and low (LMDA) Mediterranean diet, indicating that alignment with the MD was associated with a specific metabolic phenotype during pregnancy. Reduced meat intake and higher vegetable intake in the HMDA group was supported by increased levels of urinary hippurate (p = 0.044) and lower creatine (p = 0.047) levels. Serum concentrations of the NMR spectroscopic inflammatory biomarkers GlycA (p = 0.020) and GlycB (p = 0.016) were significantly lower in the HDMA group and were negatively associated with serum acetate, histidine and isoleucine (p &lt; 0.05) suggesting a greater level of plant-based nutrients in the diet. Serum branched chain and aromatic amino acids were positively associated with the HMDA group while both urinary and serum creatine, urine creatinine and dimethylamine were positively associated with the LMDA group.ConclusionMetabolic phenotypes of pregnant women who had a high alignment with the MD were significantly different from pregnant women who had a poor alignment with the MD. The metabolite profiles aligned with reported food intake. Differences were most significant biomarkers of systemic inflammation and selected gut-microbial metabolites. This research expands our understanding of the mechanisms driving health outcomes during the perinatal period and provides additional biomarkers for investigation in pregnant women to assess potential health risks.
Extended long-term follow-up of metastatic melanoma patients treated with immunotherapy: late relapses and second primary melanomas
Authors: Minor David R. , Kim Kevin B. , Karuturi R. Krishna M. , Kashani-Sabet Mohammed 
Published: December 2023

BackgroundImmunotherapy has revolutionized the treatment of patients with advanced melanoma as well as other cancers. Most studies, whether of interleukin-2 or checkpoint inhibitor therapies, have limited follow-up after 5 years, making the incidence of late relapses uncertain. In addition, the incidence of second primary melanomas in patients with stage IV melanoma treated with immunotherapy has rarely been reported.MethodsWe performed a single-institution retrospective study of stage IV melanoma patients treated with interleukin-2 or checkpoint inhibitors over the period from 1992 to 2013. We found 59 patients alive and in remission 5 years after the beginning of immunotherapy and reviewed their subsequent clinical course.ResultsThis 59-patient cohort had a median follow-up of 13.1 years, with 36 patients followed up for at least 10 years. Four patients (6.8%) had relapses of their metastatic melanoma at 5, 8, 15, and 17 years after starting the successful immunotherapy. Three of the four are still alive. Only one patient in 690 patient-years of observation had a second primary invasive melanoma.ConclusionAlthough late relapses after immunotherapy for melanoma do occur, we can conclude that the prognosis of stage IV melanoma patients in continuous remission 5 years after starting immunotherapy is excellent, with a progression-free survival of approximately 85% and a melanoma-specific survival of approximately 95% at 20 years in our series. Our incidence of second primary melanomas is lower than usually reported. These results have important implications regarding the follow-up of stage IV melanoma patients successfully treated with immunotherapy.
Understanding COVID-19 vaccine hesitancy in vasculitis patients
Authors: Butt Imama N. , van Eeden Charmaine , Kovacs Burns Katharina , Saxinger Lynora , Clifford Alison , Redmond Desiree , Cohen Tervaert Jan Willem , Yacyshyn Elaine 
Published: December 2023

ObjectiveTo identify the factors that impact COVID-19 vaccine decision-making in vaccine-hesitant vasculitis patients, and compare their perceptions with other rheumatology patients, given existence of data suggesting rheumatology patients may have disease-specific factors that influence their COVID-19 vaccine decision-making.MethodsThis cross-sectional study surveyed adult rheumatology patients from the Kaye Edmonton Clinic Rheumatology Clinic, in Canada, between June and August 2021, using an anonymous online questionnaire. Survey responses were analyzed for statistical differences using chi-square analysis.ResultsThe COVID-19 Vaccine Perceptions Survey had a response rate of 70.9%. Of the total 231 respondents, 103 patients were diagnosed with vasculitis. At the time of the survey, 10.6% of vasculitis patients refused to receive a COVID-19 vaccine compared to 6.3% for other rheumatology patients. Compared to other rheumatology patients, vaccine-hesitant vasculitis patients were significantly more concerned about almost every aspect of available COVID-19 vaccines [e.g., safety (p &lt; 0.001), components (p &lt; 0.001)], and feared that they could contract SARS-CoV-2 from a vaccine (p &lt; 0.001). These vaccine-hesitant patients were also significantly less pleased with the government's pandemic response, less confident in healthcare team-provided information (p &lt; 0.001), and more likely to report that healthcare providers had no role in their COVID-19 vaccine decision-making (p &lt; 0.001).ConclusionVaccine-hesitant vasculitis patients may have multiple considerations influencing COVID-19 vaccine hesitancy, including vaccine and disease-specific concerns, along with unfavorable perceptions of the healthcare system (government and healthcare providers). Healthcare providers can address some of these concerns by initiating patient-centered discussions around immunizations to help support educated decision-making.