bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Balance Effect of π–π Electronic Coupling on NIR‐II Emission and Photodynamic Properties of Highly Hydrophobic Conjugated Photosensitizers
Authors: Zhu Yulin , Lai Hanjian , Gu Ying , Wei Zixiang , Chen Lin , Lai Xue , Han Liang , Tan Pu , Pu Mingrui , Xiao Fan , He Feng , Tian Leilei 
Published: December 2023

AbstractDeep NIR organic phototheranostic molecules generally have large π‐conjugation structures and show highly hydrophobic properties, thus, forming strong π–π stacking in the aqueous medium, which will affect the phototheranostic performance. Herein, an end‐group strategy is developed to lift the performance of NIR‐II emitting photosensitizers. Extensive characterizations reveal that the hydrogen‐bonding interactions of the hydroxyl end group can induce a more intense π–π electronic coupling than the chlorination‐mediated intermolecular forces. The results disclose that π–π stacking will lower fluorescence quantum yield but significantly benefit the photodynamic therapy (PDT) efficiency. Accordingly, an asymmetrically substituted derivative (BTIC‐δOH‐2Cl) is developed, which shows balanced phototheranostic properties with excellent PDT efficiency (14.6 folds of ICG) and high NIR‐II fluorescence yield (2.27%). It proves the validity of the end‐group strategy on controlling the π–π interactions and rational tuning the performance of NIR‐II organic phototheranostic agents.
Perspective in Textile Energy Storage Integrated Textile Elements: Textile Materials, Structure, and Manufactured Methods
Authors: Zhang Tianyun , Wu Jiaojiao , Wang Yanci , Zhang Lirong , Ran Fen 
Published: December 2023

AbstractDesigning textile‐based energy storage with both high electrochemical performance and available textile performance is crucial for developing smart textile. In this perspective, the concept of textile‐based energy storage and the viewpoint of balancing electrochemical performance and textile performance is proposed, which is paramount to establish high‐energy‐power density textile‐based energy storage devices; some key challenges are discussed in order to provide a framework on how textile materials and structures are employed in textile energy storage research; it further compiles and generalizes current findings in the fiber, yarn, and fabric‐type components/devices area and preliminary work in the manufactured and programmed textile‐based energy storage. The objective here is to establish a set of practical principles for commercial textile energy storage from textile perspective and describe in detail the scientific and technological breakthroughs that are shaping in energy storage area.
Growth, body composition, and endocrine‐metabolic profiles of individuals with Kleefstra syndrome provide directions for clinical management and translational studies
Authors: Bouman Arianne , Geelen Joyce M. , Kummeling Joost , Schenck Annette , van der Zwan Yvonne G. , Klein Willemijn M. , Kleefstra Tjitske 
Published: December 2023

AbstractMendelian neurodevelopmental disorders caused by variants in genes encoding chromatin modification can be categorized as Mendelian disorders of the epigenetic machinery (MDEMs). These disorders have significant overlap in molecular pathways and phenotypes including intellectual disability, short stature, and obesity. Among the MDEMs is Kleefstra syndrome (KLFS), which is caused by haploinsufficiency of EHMT1. Preclinical studies have identified metabolic dysregulation and obesity in KLFS models, but proper clinical translation lacks. In this study, we aim to delineate growth, body composition, and endocrine‐metabolic characteristics in a total of 62 individuals with KLFS. Our results revealed a high prevalence of childhood‐onset overweight/obesity (60%; 28/47) with disproportionately high body fat percentage, which aligns perfectly with previous preclinical studies. Short stature was common (33%), likely due to advanced skeletal maturation. Endocrine‐metabolic investigations showed thyroid dysregulation (22%; 9/41), elevated triglycerides, and decreased blood ammonia levels. Moreover, hand radiographs identified decreased bone mineralization (57%; 8/14) and negative ulnar variance (71%; 10/14). Our findings indicate a high (cardio)metabolic risk in KLFS. Therefore, we recommend monitoring of weight and endocrine‐metabolic profile. Supporting a healthy lifestyle and screening of bone mineralization is advised. Our comprehensive results support translational research and contribute to a better understanding of MDEM‐associated phenotypes.
Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B
Authors: Niu Bowen , Liu Lingling , Gao Qian , Zhu Meng‐Min , Chen Lixiang , Peng Xiu‐Hua , Qin Boying , Zhou Xiaohui , Li Feng 
Published: December 2023

AbstractBackgroundBitter taste receptors (Tas2rs) are generally considered to sense various bitter compounds to escape the intake of toxic substances. Bitter taste receptors have been found to widely express in extraoral tissues and have important physiological functions outside the gustatory system in vivo.MethodsTo investigate the physiological functions of the bitter taste receptor cluster Tas2r106/Tas2r104/Tas2r105/Tas2r114 in lingual and extraoral tissues, multiple Tas2rs mutant mice and Gnat3 were produced using CRISPR/Cas9 gene‐editing technique. A mixture containing Cas9 and sgRNA mRNAs for Tas2rs and Gnat3 gene was microinjected into the cytoplasm of the zygotes. Then, T7EN1 assays and sequencing were used to screen genetic mutation at the target sites in founder mice. Quantitative real‐time polymerase chain reaction (qRT‐PCR) and immunostaining were used to study the expression level of taste signaling cascade and bitter taste receptor in taste buds. Perception to taste substance was also studied using two‐bottle preference tests.ResultsWe successfully produced several Tas2rs and Gnat3 mutant mice using the CRISPR/Cas9 technique. Immunostaining results showed that the expression of GNAT3 and PLCB2 was not altered in Tas2rs mutant mice. But qRT‐PCR results revealed the changed expression profile of mTas2rs gene in taste buds of these mutant mice. With two‐bottle preference tests, these mutant mice eliminate responses to cycloheximide due to genetic mutation of Tas2r105. In addition, these mutant mice showed a loss of taste perception to quinine dihydrochloride, denatonium benzoate, and cucurbitacin B (CuB). Gnat3‐mediated taste receptor and its signal pathway contribute to CuB perception.ConclusionsThese findings implied that these mutant mice would be a valuable means to understand the biological functions of TAS2Rs in extraoral tissues and investigate bitter compound–induced responses mediated by these TAS2Rs in many extraoral tissues.
Defining the stimulus in stimulus–response interventions: On the need to embrace theory and organism in stimulus–organism–response
Authors: Brendl C. Miguel , Sweldens Steven 
Published: December 2023

AbstractWe comment on a proposal in the target article that draws on “behaviorism” for developing interventions geared at attenuating negative consumer behaviors. One interpretation of this proposal emphasizes the influence of stimuli (S) on responses (R) and de‐emphasizes intervening mental processes. We contrast this S–R perspective with an S–O–R perspective that embraces O, the organism (in our context, the consumer) and in doing so attempts to explain and then leverage S–R relations. We discuss in detail that without an organism‐ and theory‐centered perspective of S–R relations, it is difficult to identify relevant stimuli and predict patterns of behavior in new contexts. We illustrate in more depth using Janiszewski and Laran's example of aiding an individual suffering from depression how this theory‐ and organism‐centered perspective can improve possible intervention strategies.
Trafficking through the blood–brain barrier is directed by core and outer surface components of layer‐by‐layer nanoparticles
Authors: Lamson Nicholas G. , Pickering Andrew J. , Wyckoff Jeffrey , Ganesh Priya , Calle Elizabeth A. , Straehla Joelle P. , Hammond Paula T. 
Published: December 2023

AbstractDrug‐carrying nanoparticles are a promising strategy to deliver therapeutics into the brain, but their translation requires better characterization of interactions between nanomaterials and endothelial cells of the blood–brain barrier (BBB). Here, we use a library of 18 layer‐by‐layer electrostatically assembled nanoparticles (NPs) to independently assess the impact of NP core and surface materials on in vitro uptake, transport, and intracellular trafficking in brain endothelial cells. We demonstrate that NP core stiffness determines the magnitude of transport, while surface chemistry directs intracellular trafficking. Finally, we demonstrate that these factors similarly dictate in vivo BBB transport using intravital imaging through cranial windows in mice. We identify that hyaluronic acid surface chemistry increases transport across the BBB in vivo, and flow conditions are necessary to replicate this finding in vitro. Taken together, these findings highlight the importance of assay geometry, cell biology, and fluid flow in developing nanocarriers for delivery to the brain.
Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes
Authors: Yuca Hafize , Aydin Bilge , Karakaya Songul , Goger Gamze , Bingöl Zeynebe , Civas Ayşe , Koca Mehmet , Demirci Betül , Sytar Oksana , Gulcin Ilhami , Guvenalp Zuhal 
Published: December 2023

AbstractIn current study antioxidant, antidiabetic, antimicrobial, anticholinesterase, and human carbonic anhydrase I, and II (hCA I and II) isoenzymes inhibition activities of Astrodaucus orientalis different parts were investigated. Achetylcholinesterse (AChE) and butyrylcholinesterse (BChE) inhibitory activities of octyl acetate were determined via molecular docking. Quantitative assessment of specific secondary metabolites was conducted using LC‐MS/MS. An examination of chemical composition of essential oils was carried out by GC‐MS/MS. A thorough exploration of plant‘s anatomical characteristics was undertaken. The highest phenolics level and DPPH antioxidant capacity were seen in root and fruit. Fruit essential oil demonstrated the highest AChE inhibition (44.13±3.61 %), while root dichloromethane sub‐extract had the best inhibition towards BChE (86.13±2.58 %). Cytosolic hCA I, and II isoenzymes were influentially inhibited by root oil with 1.974 and 2.207 μM IC50 values, respectively. The most effective extracts were found to be root all extract/sub‐extracts (except water) against C. tropicalis and C. krusei strains with MIC value 160>μg/mL. Sabinene (29.4 %), α‐pinene (20.2 %); octyl acetate (54.3 %); myrcene (28.0 %); octyl octanoate (71.3 %) were found principal components of aerial parts, roots, flowers, and fruits, respectively. Flower essential oil, fruit dicloromethane and ethyl acetate exhibited potent α‐glucosidase inhibitory activity with 900, 40, and 937 μg/mL IC50 values, respectively.
Pyrrole βC−B−N Fused Porphyrins: Molecular Structures and Opto‐Electrochemical Studies
Authors: Nandi Rajendra Prasad , Chandra Brijesh , Ghosh Subhajit , Sarma Siddhartha P. , Geremia Silvano , Hickey Neal , Thilagar Pakkirisamy 
Published: December 2023

AbstractHerein, we report the design, synthesis, structure, and electrochemical study of doubly βC−B−N fused Ni(II) porphyrins (1‐trans, 1‐cis, 2‐trans, and 2‐cis). These compounds have been synthesized from A2B2 type dipyridyl Ni(II) porphyrins (Ar=Ph for 1 a; Ar=C6F5 for 2 a) via Lewis base‐directed electrophilic aromatic borylation reactions. The solution state structures of these compounds have been established using 1H NMR, 11B NMR, 1H‐1H COSY, 1H‐13C HSQC, and 19F‐13C HSQC NMR techniques. Single crystal X‐ray analysis have revealed that 1‐trans, 1‐cis, and 2‐trans adopt ruffled conformations, with alternate meso‐carbons on the opposite sides of the mean porphyrin plane. The Soret bands in the absorption spectra of the B−N fused molecules are ~40 nm redshifted compared to unfused Ni(II) porphyrin precursors. The B−N fusion have diminished the redox potential of fused porphyrins. Although 1‐trans and 1‐cis, show four oxidation processes, 2‐trans and 2‐cis show only three oxidation processes. DFT studies have revealed that the tetrahedral geometry of the boron has induced a twist in the π‐conjugation, which destabilizes the HOMO and stabilizes the LUMO in 1‐trans, 1‐cis, 2‐trans, and 2‐cis.
Traffic offloading for postdisaster rescue in UAV‐assisted networks: A coalition formation game approach
Authors: Qiu Wanyu , Huang Chuanhe , Li Zhengfa , Ashraf M. Wasim Abbas , Wang Danxin 
Published: December 2023

SummaryIn postdisaster rescue scenario, unmanned aerial vehicles (UAVs) are effective tools to help ground users in disaster areas to transmit rescue‐critical data to the relief center in time due to their flexible mobilities and fast deployment. However, how UAVs choose disaster areas to take part in traffic offloading with limited bandwidth resources is challenging. This article investigates UAVs' access selection and disaster areas' bandwidth allocation scheme by jointly optimizing network throughput, bandwidth and UAVs' energy cost. The UAVs form coalitions to participate in traffic offloading cooperatively, where each UAV selects a disaster area independently. Specifically, the bandwidth resources are dynamically allocated to all disaster areas when a new coalition partition forms. The UAVs adjust their access choices for disaster areas when the bandwidth allocation changes. When no UAVs migrate to other disaster areas, the network achieves a stable state. The UAVs fly to the final selected disaster area and provide traffic offloading services. To resolve traffic offloading competitions yet enable cooperations among UAVs, we address the UAVs' access selection issue by coalition formation game. A gradient projection method is then proposed to allocate bandwidth resources which maximizes the benefit of the network. We demonstrate that the UAVs' access selection and disaster areas' bandwidth allocation algorithms are convergent. The simulation results demonstrate that our proposed cooperation order is better than the pareto and selfish orders, thereby increasing the benefit of the network.
Behavioral Motor Performance
Authors: Leib Raz , Howard Ian S. , Millard Matthew , Franklin David W. 
Published: December 2023

AbstractThe human sensorimotor control system has exceptional abilities to perform skillful actions. We easily switch between strenuous tasks that involve brute force, such as lifting a heavy sewing machine, and delicate movements such as threading a needle in the same machine. Using a structure with different control architectures, the motor system is capable of updating its ability to perform through our daily interaction with the fluctuating environment. However, there are issues that make this a difficult computational problem for the brain to solve. The brain needs to control a nonlinear, nonstationary neuromuscular system, with redundant and occasionally undesired degrees of freedom, in an uncertain environment using a body in which information transmission is subject to delays and noise. To gain insight into the mechanisms of motor control, here we survey movement laws and invariances that shape our everyday motion. We then examine the major solutions to each of these problems in the three parts of the sensorimotor control system, sensing, planning, and acting. We focus on how the sensory system, the control architectures, and the structure and operation of the muscles serve as complementary mechanisms to overcome deviations and disturbances to motor behavior and give rise to skillful motor performance. We conclude with possible future research directions based on suggested links between the operation of the sensorimotor system across the movement stages. © 2024 American Physiological Society.Compr Physiol14:5179‐5224, 2024.
Streamflow responses to forest and climate change in the boreal Da Hinggan Mountains, Northeastern China
Authors: Yu Zhengxiang , Hallema Dennis W. , Cai Tijiu 
Published: December 2023

AbstractBoreal forests cover vast stretches of land across all continents and represent a principal source area of clean water in the northern hemisphere. Increasingly, studies are conducted on the impact of changes in boreal forest cover on water yield; however, much remains unknown concerning the effects of forest structure changes on stream discharge over the course of multi‐decadal forest harvest cycles. In this study, we analysed long‐term hydrometeorological and forest dynamics data spanning from 1990 to 2016 from a typical boreal forest watershed in the Da Hinggan Mountains in northern China. Our objective was to quantify how changes in forest age and tree species composition affect mean annual streamflow and flow regimes in the context of a changing climate. To distinguish the effects of forest and climate changes on annual streamflow from one another, we employed a combination of a sensitivity‐based method and a temporal trend analysis. Further, we evaluated the impact of forest changes on flow regimes using four indicators: magnitude, duration, frequency, and variability. The results indicated that mean annual streamflow increased by 55.8 mm, with forest changes contributing +61.4 mm compared to −5.6 mm due to climate change (negative effect). This increase occurred when approximately 20% of mature coniferous forests transitioned to mid‐age broad‐leaved forests, accompanied by a 10% increase in total stock volume during the later period. Finally, the effect of changes in forest structure on flow regime were not significant. Our results underscore that variations in forest structure affect streamflow differently depending on stand age and species proportions. Therefore, dynamic forest structure management can benefit not only carbon sequestration but also water supply capacity in boreal forested watersheds.
Exercise catheterization in adults post‐Fontan with normal and abnormal haemodynamic criteria: Insights into normal Fontan physiology
Authors: Miranda William R. , Jain C. Charles , Borlaug Barry A. , Connolly Heidi M. , Burchill Luke J. , Van De Bruaene Alexander , Egbe Alexander C. 
Published: December 2023

AbstractAimThe normal (i.e. expected) haemodynamics in adults post‐Fontan remain poorly delineated. Moreover, the definitions of elevated exercise pulmonary artery (PA) and PA wedge pressure (PAWP) for this population have not been described.Methods and resultsSeventy‐two adults post‐Fontan undergoing exercise catheterization were categorized into abnormal (Group I, n = 59; defined as resting mean PA ≥14 mmHg and/or PAWP ≥12 mmHg, ΔPAWP/Δsystemic flow [Qs] >2 mmHg/L/min, and/or ΔPA/Δpulmonary flow >3 mmHg/L/min) and normal (Group II, n = 13) haemodynamics. Thirty‐nine patients with non‐cardiac dyspnoea (NCD) were included as controls. There was no difference in exercise arterial oxygen saturation (87% [81–92] vs. 89% [85–93], p = 0.29), while exercise PA pressure (27 [23–31] vs. 16 [14.5–19.5] mmHg, p < 0.001) and PAWP were higher (21 [18–28] vs. 12 [8–14] mmHg, p < 0.001) in Group I. At peak exercise, Group I had lower heart rate (97 [81–120] vs. 133 [112.5–147.5] bpm, p < 0.001) and Qs response (67.3 [43.8–93.1] vs. 105.9 (82–118.5) % predicted, p < 0.001) than Group II. Exercise superior vena cava pressures were higher (16 [14–22.5] vs. 5.5 [3–7.3] mmHg, p < 0.001) and arterial oxygen saturation lower (89% [85–93] vs. 97% [96–98], p < 0.001) in Group II compared to NCD, while no differences in PAWP, stroke volume index, heart rate, or Qs response were seen. If defined as two standard deviations above mean values for Group II, elevated PAWP and mean PA pressure post‐Fontan would correspond to 20.6 mmHg and 25.8 mmHg, respectively.ConclusionPAWP >20 mmHg and mean PA pressure >25 mmHg could be used to define elevated values during exercise in adults post‐Fontan. The major discrepancy in exercise haemodynamics among Group II compared to controls appears to be the degree of systemic venous hypertension and arterial desaturation.
A comparative study on porous activated carbon derived from waste biomass with varying oxygen functionalities as supercapacitor electrodes
Authors: Atika  , Dutta R. K. 
Published: December 2023

AbstractActivated carbon derived from biomasses with different oxygen‐bearing chemical constituents has been explored as supercapacitor electrode. The rice straw (RS) and eucalyptus wood biomasses were selected owing to their contrasting composition of cellulose, hemicellulose, and lignin contents. The activated carbons of these biomasses are obtained by pyrolysis at 550°C followed by thermal activation (700°C) after treatment with optimized KOH. The specific capacitance of RS‐based activated carbon (ACRS‐700), measured from galvanostatic charging‐discharging studies at 0.5 A g−1, is much higher (eg, 365 F g−1) than that of ACEW‐700 (168 F g−1). The higher specific capacitance of ACRS‐700 is attributable to: (i) significantly higher surface area (3345 m2 g−1) comprising of interconnected micro‐ and mesoporous structure; (ii) porosity of about 2.0 cm3/g; and (iii) oxygen‐rich hemicellulose contents. The possible charge storage mechanism in ACRS‐700 has been discussed. The real‐time application of ACRS‐700 has been demonstrated by lighting up red LEDs using ACRS‐700//ACRS‐700 symmetric supercapacitor device, operated with aqueous and freshly synthesized [Bu4N+][NO3−] ionic liquid as electrolytes. The maximum energy density (42.7 Wh kg−1) and the power density (1.9 kW kg−1) for ionic liquid electrolyte are favourable for supercapacitor applications.
Bioinspired radiative cooling coating with high emittance and robust self‐cleaning for sustainably efficient heat dissipation
Authors: Li Yong , Song Yingnan , Zu Hongye , Zhang Feilong , Yang Hui , Dai Wei , Meng Jingxin , Jiang Lei 
Published: December 2023

AbstractTo overcome the overheating phenomena of electronic devices and energy components, developing advanced energy‐free cooling coatings with promising radiative property seem an effective and energy‐saving way. However, the further application of these coatings is greatly limited by their sustainability because of their fragile and easy contamination. Herein, it is reported that a bioinspired radiative cooling coating (BRCC) displayed sustainably efficient heat dissipation by the combination of high emittance and robust self‐cleaning property. With the hierarchical porous structure constructed by multiwalled carbon nanotubes (MWCNTs), modified SiO2 and fluorosilicone (FSi) resin, the involvement of the BRCC improves the cooling performance by increasing ≈25% total heat transfer coefficient. During the abrasion and soiling tests, the BRCC‐coated Al alloy heat sink always displays stable radiative cooling performance. Moreover, the simulation and experimental results both revealed that reducing surface coverage of BRCC (≈80.9%) can still keep highly cooling efficiency, leading to a cost‐effective avenue. Therefore, this study may guide the design and fabrication of advanced radiative cooling coating.