bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kidney Immune Cell Characterization of Humanized Mouse Models
Authors: Noel Sanjeev , Kurzhagen Johanna T. , Lee Sul A , Sadasivam Mohanraj , Hamad Abdel R.A. , Pierorazio Phillip M. , Rabb Hamid 
Published: December 2023

Key Points

Experimental studies often fail to translate to clinical practice. Humanized mouse models are an important tool to close this gap.We immunophenotyped the kidneys of NOG (EXL) and NSG mouse strains engrafted with human CD34+ hematopoietic stem cells or PBMCs and compared with immune cell composition of normal human kidney.Human CD34+ hematopoietic stem cell engraftment results in steady renal immune cell populations in mouse kidney with key similarities in composition compared with human kidney.

Successful translation of experimental mouse data to human diseases is limited because of biological differences and imperfect disease models. Humanized mouse models are being used to bring murine models closer to humans. However, data for application in renal immune cell–mediated diseases are rare. We therefore studied immune cell composition of three different humanized mouse kidneys and compared them with human kidney. NOG and NOGEXL mice engrafted with human CD34+ hematopoietic stem cells were compared with NSG mice engrafted with human PBMCs. Engraftment was confirmed with flow cytometry, and immune cell composition in kidney, blood, spleen, and bone marrow was analyzed in different models. The results from immunophenotyping of kidneys from different humanized mouse strains were compared with normal portions of human kidneys. We found significant engraftment of human immune cells in blood and kidney of all tested models. huNSG mice showed highest frequencies of hTCR+ cells compared with huNOG and huNOGEXL in blood. huNOGEXL was found to have the highest hCD4+ frequency among all tested models. Non-T cells such as hCD20+ and hCD11c+ cells were decreased in huNSG mice compared with huNOG and huNOGEXL. Compared with normal human kidney, huNOG and huNOGEXL mice showed representative immune cell composition, rather than huNSG mice. In summary, humanization results in immune cell infiltration in the kidney with variable immune cell composition of tested humanized mouse models and partially reflects normal human kidneys, suggesting potential use for translational studies.
Influence of temperature and variety on seed germination of soybean (Glycine max L. Merr) at different germination times
Authors: Abd Ghani Rosnani , Jolánkai Márton , Omar Suhana , Khalid Noriza , Tarnawa Ákos 
Published: December 2023

Seed germination is an important stage in crop development that affects plant performance, crop yield, and quality. Many factors influence seed germination, and one of the most important factors is temperature. The closer the temperature is to the optimum, the faster germination will occur. Temperature affects seed germination in various plants and varies depending on the variety. Therefore, the effect of temperature on seed germination is necessary to investigate, also for soybean varieties. Soybean is one of the world's most valuable oil-seed crops. Generally, proper seedling establishment and germination of soybean seeds are crucial processes in the survival and growth cycle of the crop. Thus, a study was done to investigate the influence of temperature and variety on soybean seed germination at different times after sowing. The experiment was carried out at the Institute of Agronomy, Hungarian University of Agriculture and Life Sciences (MATE), Crop Production Laboratory. Seeds of two soybean varieties were subjected to three different temperatures: 15, 25, and 35 °C, and two soybean varieties, Martina and Johanna were tested. There were four germination times based on the days after sowing: Days 3, 5, 7, and 9. This experiment was set up with a completely randomized block design and four replications. According to the findings of this study, the Martina variety showed a better germination rate as well as higher vigor and viability than the Johanna variety in the first 12 days after sowing. At temperatures of 15 °C and 25 °C, both varieties achieved comparable percentages of viability, but they were more vigorous at 25 °C due to better total seedling length. Thus, the information gained from this study will indirectly determine and confirm the proper temperature for the initial growth of the Martina and Johanna varieties.
Faktor - faktor yang berhubungan dengan kepatuhan minum obat antiretroviral (ARV) pada ODHA di RSUD 45 Kuningan 2023
Authors: Herawati Ita , Iswarawanti Dwi Nastiti , Febriani Esty , Badriah Dewi Laelatul 
Published: December 2023

Kepatuhan minum obat merupakan kunci keberhasilan dalam proses pengobatan pada pasien ODHA. Data sampai oktober 2022 di Jawa Barat kumulatif HIV sebanyak 57.914 kasus dan 12.353 kumulatif kasus AIDS, jumlah penderita HIV/AIDS di kabupaten Kuningan dari tahun 2013 hingga 2021 sebanyak 702 orang. Data Poliklinik HIV RSUD 45 Kuningan per Desember 2022 jumlah pasien yang patuh minum obat ARV sebanyak 338 (43,44%). Banyak faktor yang mempengaruhi kekpatuhan minum obat pada ODHA, oleh karena itu penelitian ini bertujuan untuk menganalisis faktor-faktor yang berhubungan dengan kepatuhan minum obat antiretroviral pada ODHA di RSUD 45 Kuningan 2023. Penelitian ini merupakan studi analitik deskriptif dengan desain cross sectional. Subyek sebanyak 265 ODHA yang diambil dengan teknik accidental sampling. Instrumen yang digunakan dalam penelitian ini berupa kuesioner tertutup. Analisis data menggunakan analisis univarit, analisis bivariat (Rank Spearman) dan analisis multivariat (Regresi Logistik).
Hasil penelitian menunjukan terdapat hubungan antara usia (p = 0.000), jenis kelamin (p = 0.014), pengetahuan ((p = 0.000), dukungan keluarga (p = 0.011) dan dukungan petugas kesehatan (p = 0.000) dengan kepatuhan minum obat ARV, namun tidak terdapat hubungan antara efek samping obat ARV (p = 0.341) dan stigma (p = 0.082) dengan kepatuhan minum obat ARV pada ODHA. Variabel dukungan keluarga merupakan variabel paling dominan yang mempengaruhi kepatuhan minum obat ARV pada ODHA.
Max Horkheimer y su teoría crítica en movimiento: las figuraciones sobre el futuro, la agencia del intelectual y la modernidad
Authors: Rigalli Lucia 
Published: December 2023

En el presente artículo, proponemos analizar la proyección de futuro en los escritos de Max Horkheimer, el ideal del intelectual como participante activo de la acción política y su noción de modernidad. Partimos de la premisa de que estos tres aspectos fueron cambiando conforme avanzó su vida, la situación política más general y su trayectoria profesional. Utilizaremos como fuentes fundamentalmente sus escritos sobre Teoría Crítica (1937), Historia y Psicología (1932) , Obreros y empleados en vísperas del Tercer Reich (1929) así como el trabajo posterior Crítica de la razón instrumental (1947).
PENANGANAN STUNTING DALAM PERSPEKTIF MODEL KEBIJAKAN KONVERGENSI DI KABUPATEN LOMBOK TIMUR
Authors: KABUL LALU MUH. 
Published: December 2023

A new model which implemented to handle stunting called convergence policy model. The aim of the study is to analysis the convergence policy model. The study method used is mixed methods, namely quantitative and qualitative. The result of study showed that convergence policy model which is recently implemented (“existing model”) consist of 8 integrated action where responsibility of each action is organization/agencies at regency level. In order to accelerate increasing of stunting prevalency, the “existing model” need to improve tobe a “recommended model” which consist of 9 integrated action where responsibility of each action is not only organization/agencies at regency level, but also village government.
ANALISIS IMPLEMENTASI PROGRAM PERLINDUNGAN ANAK TERPADU BERBASIS MASYARAKAT (PATBM) DALAM PENANGANAN KASUS KEKERASAN TERHADAP ANAK DI KABUPATEN SUMBAWA BARAT
Authors: HASTUTY AYU DEWI , UMAR UMAR , ANGGARA MIETRA 
Published: December 2023

This research discusses the analysis of the implementation of the Community-Based Integrated Child Protection Program (PATBM) in handling cases of violence against children in West Sumbawa Regency. The aims of this research are; 1) To find out the implementation of the PATBM program in handling violence against children in West Sumbawa Regency. 2) To analyze community perceptions of the implementation of the PATBM program in handling cases of violence against children in West Sumbawa Regency. This research uses a qualitative descriptive approach because researchers want to find facts related to the effectiveness of implementing PATBM in the context of monitoring and evaluation at the West Sumbawa Regency Family Planning, Women's Empowerment and Child Control (DP2KBP3A) Population Control Service. The research informants involved were 25 respondents. These respondents were divided into two groups, namely: the first group, Head of Service, Head of Division, 2 Kasie, and 1 head of UPTD PPA West Sumbawa Regency with a total of 5 respondents, the second group, representing the community victims of violence in West Sumbawa Regency. The research results showed that the implementation of the Community-Based Integrated Child Protection Program (PATBM) in West Sumbawa Regency reflects a very relevant approach in handling cases of violence against children. Community perception of the implementation of the Community-Based Integrated Child Protection Program (PATBM) in handling violence against children in West Sumbawa Regency is very important in evaluating the effectiveness of this program. The implementation of the PATBM program in handling violence against children in West Sumbawa Regency has had a significant positive impact in protecting children from various forms of violence
IMPLEMENTASI ETIKA PROFESI DAN LOCUS OF CONTROL TERHADAP KINERJA AUDITOR
Authors: JAZADI FURQAN RAMADHAN 
Published: December 2023

The purpose of this study is to provide an overview of the application of professional ethics and locus of control to auditor performance either by internal auditors within a company or auditors at a Public Accounting Firm. This research uses the Systematic literature Review (SLR) method. This method is carried out by reviewing several national and international standard journals. The results showed that the quality of auditor performance audit results is dominantly influenced by several situational factors and characteristics of an auditor, for example professional ethics and locus of control that exist for all auditors. This internal locus of control has a positive effect on audit quality, the more internal the locus of control, the higher the audit quality. The external locus of control has a negative effect on audit quality and audit quality decreases. Certified auditors who have good professional ethics will have a positive impact on the auditor's performance. The better the professional ethics of an auditor, the better the auditor's performance will be. An auditor's internal locus of control will behave ethically compared to the auditor's external locus of control which tends to behave unethically.
MANAJEMEN KOMUNIKASI MEDIA DIGITAL DI PERGURUAN TINGGI SWASTA WILAYAH NON-PERKOTAAN (STUDI KASUS PTS DI SULAWESI BARAT)
Authors: Kadir Darmawati , Arif Muhammad Ridwan , Asdar Muhammad 
Published: December 2023

The research aims to analyze the management of digital communication media used in private university organizations (PTS) with a case study of PTS in West Sulawesi, and evaluate the types of digital communication media used. This research was conducted on a sample of three campuses in West Sulawesi Province. This research is qualitative with a case study approach, with the paradigm used is the constructivism paradigm. The sample was analyzed using question construction data based on the research variables raised, so that the perceptions of the organizational team consisting of structural officials, lecturers, and students were collected. The results of this study reveal that the application of communication media in the digital era is closely related to management patterns that include planning, implementation, control, and evaluation stages with a multi-channel communication approach. Digital media such as instant messaging applications, webinar platforms, and social media play an important role in supporting interaction and collaboration between students, lecturers, and university leaders in various academic and administrative aspects. The use of these various communication channels successfully supports information distribution, coordination, exchange of views, and expression of feelings to achieve organizational goals. Although guidelines and policies still need to be improved, the positive impact of digital media in education, research, and community service, especially during the pandemic, is clear, and can even resolve internal conflicts.
NOUN STRESS IN UKRAINIAN LANGUAGE: DIACHRONY OF CODIFICATION (BASED ON "THE FIRST READER FOR PUBLIC SCHOOLS" BY A. KRUSHELNYTSKYI, O. POPOVYCH, B. LEPKYI (1918))
Authors: Hnatyuk M. , Kharchuk L. 
Published: December 2023

The article traces the peculiarities of noun stress in "The First Reader for Public Schools" (1918) by A. Krushelnytskyi, O. Popovych, and B. Lepkyi, which has not been the subject of linguistic research. This publication introduces the textbook by the mentioned authors into the academic discourse. The mentioned textbook was used in practice in primary and secondary Ukrainian-language education in western Ukraine during the time of Austria-Hungary. The norm for all levels of language at that time was the "Malorusko-German Dictionary" by E. Zhelekhivskyi and S. Nedielskyi (1886). Based on this lexicographical work, a phonetic orthography, known as "zhelekhivka," was formed, which the Ministry of Education recognized as official for Ukrainian education. The process of standardizing literary stress in the Ukrainian language is still ongoing today. Therefore, analyzing stresses in a school textbook published over a hundred years ago can help shed light on certain accentuation patterns that have evolved over time. Furthermore, the collected empirical material will enable researchers to substantiate the choice of one or another normative stress pattern. During the research process, it was discovered that the primary stress patterns in "The First Reader" align with contemporary normative stress patterns found in various paper and electronic dictionaries. The article also analyzed non-standard stress patterns in current usage. In the stress patterns of first-declension nouns, the authors of "The First Reader" systematically employ dactylic stress, which is a characteristic feature of the Ukrainian language. However, within the framework of the current accentuation norms, this dactylic stress is often considered incorrect in many cases. Some first-declension nouns exhibit stress patterns influenced by dialectal environments and the influence of the Polish and German languages. This is especially relevant when it comes to the stress patterns of borrowed words. In "The First Reader," one can also observe the form-distinguishing and content-distinguishing functions of stress, which differ from contemporary accentuation models. Among the second-declension nouns, stress patterns with an emphasized prefix were identified, which could partially enrich the normative basis of contemporary literary language. Additionally, a group of diminutive nouns with consistently stressed final syllables was identified. "The First Reader" does not feature deviant stress patterns among third and fourth declension nouns. The findings can be used in further scientific research, lexicographic practice, or in the educational process.
MATERIALS OF DIALECTOLOGICAL PRACTICE AS A SOURCE OF THE STUDY OF MODERN MIDDLE POLISSYA DIALECTS
Authors: Hrymashevych H. 
Published: December 2023

The article confirms the status of the materials of dialectological practice as an important source for the study of Ukrainian dialects from the position of synchrony in general and the study of the modern state of Middle Polissya dialects in particular, given the possibility of recording colloquial speech with the help of various technical devices, which enables its authenticity and reliability. Records of samples of dialectal connected speech, recorded by students of Zhytomyr State University named after Ivan Franko during dialectological practice in 2022–2023 from native speakers of mostly older generations, testify to the preservation of defining dialectal features primarily at the phonetic and morphological levels, which are the most static and undergo the least changes, compared, for example, with the lexical one. The analyzed dialect texts most clearly demonstrate the presence of phonetic features in the realm of vocalism, in particular, the functioning of the sounds of heterogeneous articulation [o] and [e] both in the place of etymological counterparts, and ѣ as a reflex, the absence of [i] and its replacement by other sounds (for example, [i] – in the northern regions Zhytomyr Oblast, [иі] – a bit further south, while the last feature led to a significant number of palatalized sounds, on the one hand, and on the other hand, the presence of dispalatalization of a number of consonant sounds, which has been known in the studied area for a long time. Among the morphological features, the most obvious are the presence of full uncontracted forms of adjectives, pronouns and numerals, truncated forms of adjectives, numerals, pronouns in the masculine singular nominative case, preservation of the ancient ending -e in neuter nouns, the function of the ancient infinitive in -t, etc. At the same time, the materials of dialectological practice actualized a number of problems, which mostly due to extralinguistic factors (the Russian-Ukrainian war, the migration of people from the occupied territories or those where hostilities are ongoing to the territory of Polissya, the migration of the Poleschuks themselves from areas bordering Belarus, the decrease in the number of the autochthonous population, the presence of education in the majority of the inhabitants-speakers etc.) appear every time before dialectologists in the process of collecting speaking material and its subsequent interpretation. In general, the Middle Polissya ethnolinguistic continuum demonstrates durability and continuity in linguistic terms from the most ancient state to the present.
APOCRYPHAL AND HAGIOGRAPHIC LEGENDS IN THE COLLECTION "LEGENDS OF OLD KYIV" BY NATALENA KOROLEVA: AN INTERTEXTUAL ASPECT
Authors: Tkachuk Yu. 
Published: December 2023

The article explores the hagiographic narratives in the collection "Legends of Old Kyiv" by Natalena Koroleva in the context of intertextuality. It reveals the characteristics and literary functions of intertextual connections in the creation of new artistic compositions. The focus is on the artistic richness of apocryphal and hagiographic legends in the collection. The hagiographies of saints interpreted by the writer are described as being woven into new narratives closely intertwined with the Bible, the Gospels, the history of Kyiv Rus, the Kyiv-Pechersk Monastery and one of the most well-known literary sources, such as "The Kyiv-Pechersk Paterikon" (narratives about the lives of monks). The focus is on the Gospel apocrypha, as well as on the narratives that are included in "The Kyiv-Pechersk Paterikon" dating back to the establishment of the Kyiv Monastery by Theodosius.
Natalena Koroleva skillfully synthesizes well-known narratives about the deeds of canonized and non-canonized saints and righteous individuals creating new characters that focus on the moral values of humanity. The author emphasizes the semantics of her writing, the significance and the symbolic meaning of her intention. In the apocryphal legends of the collection "Legends of Old Kyiv" by Natalena Koroleva, there are both genetic connections and a new interpretation and methodology for reading the hagiographies of saints.
The article specifically emphasizes the intertextual aspect not as a mere retelling of text within a text but as primary texts serve as the starting aesthetic point for the creation of new metatexts.
A comparative characterization and analysis are offered of the author's interpretations of apocryphal narratives with the original versions of such saints, for example, the Gospel Marys, Saint Michael, Apostle Andrew, Alipy the Iconographer, his disciple Gregory, abbots Theodosius, Anthony and others. In the course of our research, the relevance of intertextual insertions and their aesthetic enrichment when dealing with apocryphal and hagiographic texts is highlighted.
PROCESSING OF WINTER TRITICALE GRAIN INTO VARIOUS FLOUR ACCORDING TO THE DEVELOPED TECHNOLOGICAL SCHEME
Authors: Кандроков Р.Х. , Кусова И.У. , Кирюшин В.А. , Кривонос И.Н. 
Published: December 2023

Проведены исследования по определению мукомольных свойств зерна озимого тритикале по разработанной лабораторной развитой технологической схеме переработки с применением драных, размольных, ситовеечных и шлифовочных систем. Установлено, что размол зерна тритикале в сортовую хлебопекарную муку по развитой технологической схеме с применением ситовеечных и шлифовочных систем даёт значительное увеличение выхода низкозольной тритикалевой сортовой хлебопекарной муки. Переработка зерна тритикале в хлебопекарную муку по развитой технологической схеме позволяет получать от 72 до 79,6% сортовой тритикалевой хлебопекарной муки, при этом выход тритикалевой муки высшего сорта Т-60 составляет от 54,8 до 72,1%. Это свидетельствует о высокой эффективности разработанной развитой технологической схемы и хороших мукомольных свойствах исходных образцов зерна тритикале. Кумулятивная кривая зольности тритикалевой муки по развитой технологической схеме с применением шлифовочных и ситовеечных систем переработки может быть представлена в виде двух, а не трёх линейных участков, как при переработке по сокращённой технологической схеме. Коэффициент аппроксимации с высокой степенью достоверности при формировании потоков тритикалевой муки А и Б составил 97%, а для потока В – 99%. Установлено, что зерно тритикале сорта Александр уступало по своим мукомольным свойствам сортам Валентин и Водолей, что связано с низкой крупообразующей способностью данного сорта.
Studies were carried out to determine the milling properties of winter triticale grain according to the worked laboratory developed technological scheme for processing using break, reduction, sieve and scratch systems. It was established that grinding triticale grain into varietal baking flour according to a developed technological scheme using sieve and scratch systems gives a significant increase in the yield of low-ash triticale varietal baking flour. Processing of triticale grain into baking flour according to the developed technological scheme allows to produce from 72 to 79.6% of triticale baking flour, at the same time output of triticale flour of the highest grade is T-60 from 54.8 to 72.1%. This indicates the high efficiency of the worked developed technological scheme and the good milling properties of the initial triticale grain samples. The cumulative curve of flour ash content of triticale flour according to a developed technological scheme using scratch and sieve processing systems can be presented in the form of two, and not three linear sections, as in processing according to the reduced technological scheme. The approximation coefficient with a high degree of reliability in the formation of triticale flour flows A and B was 97%, and for flow C – 99%. It was established that the grain of triticale of the Alexander variety was inferior in its flour milling properties to the varieties Valentin and Vodoley, which is due to the low groats-forming ability of this variety.