bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microservices for information support of multi-agent systems: methods of collection, monitoring and decision-making
Authors: Bryzgalov A. A. 
Published: January 2025

Purpose. The purpose of this article is to develop methods and algorithms of microservice implementation for information support of multi-agent systems that implement the functions of digital twins of the enterprise. Particular attention is paid to the implementation of data collection, monitoring, diagnostics and decision-making functions that ensure effective interaction between product agents and resource agents based on service level agreements (SLAs).Research methods. The research uses methods of building a microservice architecture to separate and autonomously perform functions such as data collection, monitoring and diagnostics in order to optimize SLA and increase system reliability. To increase the system's resilience to security threats, access control, data encryption, and anomaly analysis stages have been added to the algorithms. The methodology includes adaptive management of SLA parameters, the use of distributed data processing and the use of analytical algorithms for decision-making, as well as mechanisms to identify potential threats and unauthorized access.Results. The proposed methods and algorithms make it possible to create a flexible and scalable multi-agent system capable of adapting to changing conditions and ensuring stable and safe operation of digital counterparts. Using SLA to regulate the interaction of agents improves the consistency of their actions, increases the accuracy of monitoring and protects data, maintaining high reliability and security of the system.Conclusion. The results show that the microservice approach, the use of SLA and the integration of security measures significantly increase the efficiency and reliability of multi-agent systems, allowing agents to adapt to changes, respond promptly to deviations and prevent possible threats. The use of these methods can significantly improve asset management in network enterprises, maintaining their competitiveness, sustainability and security in the context of digital transformation.
Mobile Health App as an Auxiliary Tool in Management of Atopic Dermatitis in Children: Randomized Controlled Trial
Authors: Zvulunov Alex , Lenevich Stepan , Migacheva Natalia 
Published: January 2025

Abstract

Background
Mobile health apps can boost treatment adherence and support disease management at home. The Atopic App and web-based Atopic School patient education program offer a chance to enhance adherence to atopic dermatitis (AD) management.

Objective
We aim to evaluate the feasibility, acceptability, and preliminary efficacy of the Atopic App mobile health intervention in the managing of AD in children.

Methods
A randomized controlled study in children with AD divided participants into 3 groups: a control group (no app), an observational group with the app, and an interventional group with investigator supervision. Patients were examined at screening and follow-up visits 1 and 2 at 3-month intervals. Outcome measures included SCORAD (Scoring Atopic Dermatitis) for objective severity and Patient-Oriented Eczema Measure (POEM) for subjective effectiveness. Statistical analysis used paired t tests (2-tailed), the Mann-Whitney U test, and multiple regression.

Results
Fifty-eight participants entered this study (38 boys and 20 girls): group 1 (control) comprised 17 patients, while experimental groups 2 and 3 consisted of 20 and 21 patients, respectively. The rates of missed appointments were similar and statistically insignificant across the groups. All groups showed a significant decrease in SCORAD and POEM scores (P<.05). Usage of the app for ≥8 days showed a more significant decrease in severity scores compared to those who used it for ≤7 days, or did not use it at all. Participants who used the app for ≥8 days had a median SCORAD of 6.25 (95% CI 4.6‐14.1; IQR 4-16.3) at visit 1, significantly lower than nonusers (17.9, 95% CI 13.9‐24.0; IQR 13.9-24; P=.03) and those using it ≤7 days (13, 95% CI 9.35‐27; IQR 7.2-27; P=.04). Their median POEM of 2 (95% CI 1.0‐4.5; IQR 1-5.3) was also significantly lower than those using the app ≤7 days (9, 95% CI 2‐12; IQR 2-12; P=.04) and lower, though not significantly, than nonusers (7, 95% CI 1‐9; IQR 1-9; P=.14). Additionally, using the Atopic App for ≥8 days after the screening visit strongly predicted a decrease in both SCORAD and POEM scores (P=.01 and P=.04, respectively). The time since the screening visit significantly predicted increased outcome scores, while prescriptions of topical calcineurin inhibitors, oral antihistamines, and oral antibiotics were weak and insignificant predictors of score changes.

Conclusions
Our findings indicate that the Atopic App is helpful tool in managing AD in children, and they underscore the potential of mobile health interventions in the disease management.
Morphofunctional features of the zonular apparatus in complicated cataract
Authors: Skrypnyk R.L. , Krasnozhan O.V. 
Published: January 2025

Background. The number of cataract patients in the world reaches 18 million people, and by 2025, it may reach 40 million people. Most authors believe that 50 % of patients have a complicated cataract. Treatment of such patients is an urgent and socially significant problem. Complicated cataract, as a rule, is combined with varying degrees of weakness of ligament apparatus of the lens. It complicates the surgical technique and significantly increases the risk of developing operative and postoperative complications. The diagnosis of hidden disorders of the ligament apparatus is difficult, and some authors (G.E Wenge, A.S. Sarzhevskyi) made attempts to identify them. The proposed methods for calculating the degree of displacement of the lens-iris diaphragm are insufficient to detect disturbed anatomical and topographic relations of the structures of the iridociliary zone. The diagnostic approach to assessing the state of the ligament apparatus of the lens in patients with complicated cataract has not been sufficiently stu­died. So, there is a need to analyze it preoperatively in this cohort, which prompted the initiation of this research. The purpose was to assess the state of the ligament apparatus of the lens in patients with complicated cataract. Materials and methods. A comprehensive ophthalmic examination in the preoperative period was carried out in 83 patients with cataract, 57 (114 eyes) of them had uncomplicated cataract (controls) and 26 (52 eyes) had cataract combined with primary open-angle glaucoma (main group). In addition, the clinical signs of weakness of zonules of Zinn were studied, and also, with the help of A-scan ultrasound, — the biometric parameters of the eye: thickness of the native lens, the anterior chamber depth and the anterior-posterior axis of the eye in the patients’ sitting and lying position, which corresponded to the vertical and horizontal position of the eyeball. To evaluate the position of the lens-iris diaphragm, the anterior chamber depth + half the thickness of the lens were calculated, as well as the Lowe coefficient. Results. Among patients with complicated cataract combined with primary open-angle glaucoma, clinical signs of insufficiency of the ligament apparatus of the lens are detected in 12.5 % of cases, indirect signs — in 42.3 %. A change in the Lowe coefficient for horizontal and vertical positions of the eyeball was not observed in controls, and among patients with complicated cataract, it occurred in 13.1 % of cases. Conclusions. The Lowe coefficient makes it possible to assess the state of the lens-capsular apparatus, the degree of mobility of the lens-iris diaphragm. The difference of the coefficient Lowe in the vertical and horizontal positions of the eyeball above 0.1 characterizes the displacement of the lens-iris diaphragm in complicated cataract and indicates the presence of a hidden subluxation of the lens of the first degree.
Efficiency of surgical treatment for complicated cataract: clinical and functional analysis
Authors: Tykhonchuk N.A. , Greben N.K. , Skrypnychenko I.D. , Zadorozhna A.I. , Gavrylyak I.V. 
Published: January 2025

Background. Despite the successes of ophthalmic surgery, the treatment of complicated cataract remains challenging due to concomitant conditions such as lens subluxation and glaucoma. The purpose of the study was to assess the clinical and functional state of the eye in patients with complicated cataract after lens extraction. Materials and methods. The study involved 54 patients: 36 with uncomplicated cataract (controls) and 18 (main group) with cataract complicated by primary open-angle glaucoma (POAG). They underwent an ophthalmic examination, including visometry, tonometry, echobiometry, and ophthalmoscopy. The examination was performed before surgery, the next day, 1, 3 and 6 months after phacoemulsification. Results. Six months after surgery, 97.23 % of controls and 94.45 % of patients in the main group had visual acuity ≥ 0.5. On the first day after phacoemulsification, the mean intraocular pressure (IOP) increased by 3.14 ± 0.15 mm Hg in the control group and by 0.84 ± 0.02 mm Hg in patients with POAG, but by the end of the follow-up, there was a decrease in IOP in 50 and 44.5 % of cases, respectively, compared to preope­rative values. One month after surgery, the anterior chamber depth increased by 0.94 mm in controls and by 0.44 mm in patients of the main group, remaining stable until the end of the follow-up. Conclusions. Clinical follow-up of patients with uncomplicated cataract and cataract complicated by POAG showed that after phacoemulsification, there was an improvement in visual function, stabilization of IOP and an increase in the anterior chamber depth. An increase in IOP on the first day after surgery is transient, and the dynamics of indicators over 6 months confirms the effectiveness of surgical intervention.
El dato biométrico y la videovigilancia como herramientas de control social
Authors: Burgueño María Raquel 
Published: January 2025

El presente trabajo tiene como fin comprender los alcances de la videovigilancia desde una reflexión socio-jurídica en un ámbito donde las legislaciones internacionales tienen diferentes miradas. En talsentido entendemos que la protección de datos personales, en este caso, el de la biometría facial, se encuentra en constante tensión con otros bienes jurídicos como la seguridad y la integridad de las personas y sus bienes. Algunos Gobiernos, como el caso de China, consideran que los datos personales pertenecen al Estado Nacional. Por el contrario, para los Estados Unidos de América, los datos personales se encuentran estrechamente relacionados con el concepto de “Mercado”, y le pertenecen a éste. Finalmente, en un tercer bloque la Unión Europea reconoce la exclusividad del titular del dato, como único propietario de éste, entendiendo así, que los datos biométricos deben ser protegidos a través de regulaciones que aseguren una efectiva protección de los datos personales y consecuentemente de los derechos humanos digitales
Using Semantic Similarity to Proxy for Knowledge Structures in Accounting Research
Authors: Janvrin Diane J. , Raschke Robyn L. , Schneider Gary P. , Hsieh Sheng-Feng 
Published: January 2025

ABSTRACT
Accountants and auditors frequently make judgments that require complex evaluations of facts and rules. Researchers examine these judgments by conducting experiments in which participants make accounting decisions and then describe the information they used and how they used it in making their decisions. These elicited descriptions provide researchers insight into participants’ knowledge structures. This study uses a design science approach to develop a semantic similarity (a natural language processing analytic method) measure of how closely participants’ knowledge structures match an exemplar knowledge structure derived from authoritative accounting sources. The study then tests the semantic similarity metric in an experimental setting with two accounting tasks: assessing inventory obsolescence and production process business risk. Results show that the semantic similarity metric evaluates the knowledge structure match comparably to other methods requiring human judges. Importantly, the semantic similarity metric yields comparable results more efficiently.
Pembelajaran Berbasis TPACK Berbantuan Media Video Animasi Berpengaruh Terhadap Perilaku Hidup Bersih dan Sehat Pada Anak Usia Dini
Authors: Dewi Ida Ayu Nyoman Sintha , Tirtayani Luh Ayu 
Published: January 2025

Melihat masih rendahnya penerapan pola hidup bersih dan sehat pada anak dan kurangnya media pembelajaran yang digunakan oleh guru untuk meningkatkan perilaku hidup bersih dan sehat (PHBS) di sekolah. Hal ini disebabkan oleh pemilihan media pembelajaran yang kurang bervariasi dan optimal sehingga anak merasa sulit memahami isi materi yang diberikan. Berdasarkan masalah tersebut maka diperlukan media pembelajaran seperti video animasi yang dapat meningkatkan perilaku hidup bersih dan sehat. Penelitian ini bertujuan untuk menganalisis pengaruh yang signifikan pembelajaran berbasis TPACK berbantuan media video animasi terhadap perilaku hidup bersih dan sehat pada anak usia dini. Jenis penelitian ini adalah eksperimen semu dengan rancangan non-equivalent control group design. Populasi penelitian ini adalah seluruh anak kelompok B TK Negeri Pembina Denpasar sebanyak 75 orang. Pengambilan sampel penelitian menggunakan teknik cluster random sampling. Sampel yang terpilih sebagai kelompok eksperimen adalah kelompok B1 sebanyak 19 anak. Metode pengumpulan data yang digunakan adalah metode non test mengggunakan ceklist observasi. Hasil penelitian ini menunjukkan rata-rata posttest pada kelompok eksperimen 89,78 sedangkan pada kelompok kontrol 66,55 dengan skor maksimal adalah 100. Hasil analisis data diperoleh thitung sebesar 8,09 dengan taraf signifikan 5% dan dk = 35 maka ttabel adalah 2,021. Berdasarkan analisis bahwa thitung > ttabel (8,09 > 2,021), maka artinya H0 ditolak dan H1 diterima. Dengan demikian dapat disimpulkan bahwa pembelajaran berbasis TPACK berbantuan media video animasi berpengaruh terhadap perilaku hidup bersih dan sehat pada anak usia dini.
Cultivating Sporeless Pleurotus ostreatus (Pearl Oyster) Mushrooms on Alternative Space-Based Substrates under Elevated Carbon Dioxide
Authors: Musci Jared , Schaler Rachel Atanowski , Hummerick Mary , Pryor Barry , Smith Trent , Haveman Natasha 
Published: January 2025

Abstract
Fungi are natural decomposers that degrade organic substrates for growth. On Earth, fungi grow and produce mushrooms on various natural substrates, often with little to no added nutrient supplements. Existing waste substrates found on board the International Space Station (ISS) such as inedible biomass from plants, clothing, and plastic wastes from prepackaged foods could be repurposed for food production and advance the capacity for more sustainable long-duration space missions. The sporeless oyster mushroom (Pleurotus ostreatus) strain SPX was grown on seven substrates in varied combination recipes to investigate how ISS waste streams could be used to cultivate mushrooms. In addition, food safety analyses were performed to assess the feasibility of mushroom cultivation as a low-risk food option. Results show that waste streams of cotton t-shirts and inedible biomass from plants are potential substrates that could support mushroom cultivation on board the ISS. By using materials that are already available on the station, the upmass needed to support such efforts is reduced and waste products can be recycled to potentially yield more food. This investigation was intended to identify the feasibility of incorporating mushrooms as a potential space crop without the requirement of a large upmass of substrates being brought to the ISS.
Smartphone morality: A mixed-method study of how young adults judge their own and other people’s digital media reliance
Authors: Jansson André , Fast Karin , Bengtsson Stina , Lindell Johan 
Published: January 2025

Abstract
Escalating smartphone reliance is a debated issue, especially when it comes to the digital wellbeing of young people. Hence, this article addresses smartphone use as a morally contested activity among young adults. We first analyse the existence of moral dissonance pertaining to one’s own smartphone use – whether one uses the device according to internalised norms or not. Second, we explore moral distancing – to what extent morally problematic smartphone use is ascribed to others rather than to oneself. Combining survey results with focus-group interviews from Sweden, the study shows that moral distancing is less pronounced among young adults than in the overall population. It also shows that young people’s capacity to domesticate digital media in a morally congruent way plays into the social reproduction of gender and class. While the smartphone is socially normalised, young adults, especially women, report a great deal of moral reflexivity and distress in relation to the device.
Upregulation of phosphatase and tensin homolog deleted on chromosome ten inhibits lung cancer cell proliferation by suppressing the oncogene polo-like kinase 1 and inducing autophagy
Authors: Jiang Weizhou , Wang Pei , Huang Limin 
Published: January 2025

Objective:
Lung cancer is one of the main causes of cancer-related mortality globally, and it poses considerable therapeutic challenges. Polo-like kinase 1 (PLK1) exhibits upregulation in lung cancer, and PLK1 silencing promotes autophagy in lung cancer cells, which inhibits tumor progression. The phosphatase and tensin homolog deleted on chromosome ten (PTEN) acts as a tumor suppressor gene. This study aimed to investigate whether PTEN regulates autophagy and inhibits lung cancer-cell proliferation by suppressing PLK1.

Material and Methods:
In this study, we evaluated cell proliferation by silencing or overexpressing PLK1 and PTEN in A549 cells through 5-ethynyl-2'-deoxyuridine labeling and cloning experiments. The autophagy levels were detected through transmission electron microscopy, real-time quantitative polymerase chain reaction, and Western blot. Finally, the results of in vitro experiment were further verified using an in vivo xenograft tumor animal model.

Results:
The upregulation of PTEN suppressed PLK1 expression in lung cancer cells and reduced their proliferation rate. In addition, the overexpression of PTEN has been associated with the growth of lung cancer tumors. In parallel, the levels of autophagy of lung cancer cells rose in response to PTEN upregulation in vivo and in vitro.

Conclusion:
This study revealed that PTEN promotes the autophagy of lung cancer cells and inhibits cell proliferation and tumor growth by suppressing PLK1 expression. This finding provides a new strategy for lung cancer treatment by utilizing the autophagy-regulating effect of PTEN to inhibit lung cancer growth by targeting PLK1.
Continuity in the management of patients with chronic cicatricial stenosis of the larynx and trachea from childhood to adulthood
Authors: Kirasirova E.A. , Grachev N.S. , Zyabkin I.V. , Tyutina S.I. , Mamedov R.F. , Piminidi O.K. , Lafutkina N.V. 
Published: January 2025

The article presents a literature review that analyzes the occurrence of chronic cicatricial stenosis of the larynx and trachea in childhood and the difficulties of its treatment. Laryngeal and tracheal cicatricial stenosis is one of the most complex and unsolved problems of modern otorhinolaryngology in both children and adults. Despite the variety of methods of conservative and surgical treatment, including endoscopic minimally invasive surgery and open laryngeal and tracheal reconstruction, there is no single algorithm for the management of patients with cicatricial stenosis of the larynx and trachea. Treatment is often long-term and multistage, thus, coordination between pediatric and adult institutions is crucial for timely and qualified medical care.
В статье представлен литературный обзор, в котором проведен анализ возникновения хронического рубцового стеноза гортани и трахеи в детском возрасте и трудностей его терапии. Гортанно-трахеальный рубцовый стеноз является одной из самых сложных и нерешенных задач современной оториноларингологии, касающейся как детей, так и взрослого населения. Несмотря на многообразие методов консервативного и оперативного лечения, включая эндоскопическую малоинвазивную хирургию и открытую гортанно-трахеальную реконструкцию, единого алгоритма ведения пациентов с рубцовым стенозом гортани и трахеи нет. Лечение зачастую длительно и многоэтапно, в связи с чем актуален вопрос преемственности между детскими и взрослыми учреждениями с целью оказания своевременной и квалифицированной медицинской помощи.
Surgical treatment of obstructive sleep apnea in children. Literature review
Authors: Fisenko A.P. , Rusetsky Yu.Yu. , Latysheva E.N. , Malyavina U.S. , Dzhafarova M.Z. , Spiranskaya O.A. 
Published: January 2025

The article presents current view on surgical treatment of obstructive sleep apnea syndrome in children. Publications concerning efficacy of different surgeries on lymphoid ring such as adenoidectomy, tonsillotomy, tonsillectomy, adenotonsillectomy combined with pharyngoplasty, tuboplasty, were studied. The role of sleependoscopy in case of small adenoid and tonsils or residual symptoms of sleep apnea after the primary surgery is discussed. Variants of surgical treatment for persistent sleep apnea after adenotonsillectomy, including septoplasty and turbinoplasty, tongue base surgery, supraglottoplasty and mandibular advancement, are analysed.
В статье представлен современный взгляд на хирургическое лечение синдрома обструктивного апноэ сна у детей. Изучены публикации, посвященные различным операциям на лимфаденоидном глоточном кольце, оценена эффективность аденотомии, тонзиллотомиии, тонзиллэктомии, рассмотрены варианты фарингопластики при аденотонзиллэктомии. Обсуждается роль слипэндоскопии при отсутствии гипертрофии небных миндалин и сохранении обструктивного апноэ после первичной операции. Проанализированы варианты хирургического лечения при gерсистирующем апноэ после аденотонзиллэктомии, в т.ч. операции на перегородке носа и носовых раковинах, корне языка, гортани, нижней челюсти.