bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat. Relevance for anxiolytic actions
Authors: Hernández-Mondragón Juan Carlos , Hernández-Hernández Dexter A. , Crespo-Ramírez Minerva , Prospero-García Oscar , Rocha-Arrieta Luisa , Fuxe Kjell , Borroto-Escuela Dasiel O. , Perez de la Mora Miguel 
Published: October 2023

Introduction: The amygdala is a limbic region of high value for understanding anxiety and its treatment. Dopamine D2 receptors (D2Rs) and oxytocin receptors (OXTRs) have both been shown to participate in modulating anxiety involving effects in the amygdala. The goal is to understand if D2R–OXTR heterocomplexes exist in the central amygdala and if, through enhancing allosteric receptor–receptor interactions, may enhance anxiolytic actions.Methods: The methods used involve the shock-probe burying test, the in situ proximity ligation assay (PLA), image acquisition and analysis, and the BRET2 assay. Bilateral cannulas were introduced into the amygdala, and the effects of the coadministration of oxytocin and the D2R-like agonist quinpirole into the amygdala were studied.Results: The combination treatment enhanced the anxiolytic effects compared to the single treatment. The D2R/D3R antagonist raclopride blocked the effects of the combination treatment of oxytocin and the D2R agonist, although oxytocin is regarded as a distinct modulator of fear-mediating anxiolytic effects. In situ PLA results indicate the existence of D2R–OXTR heteroreceptor complexes and/or the co-location of OXTR and D2R within the same cell membrane nanodomains in the central amygdala. With BRET2, evidence is given for the existence of D2R–OXTR heteromers in HEK293 cells upon co-transfection.Discussion: The enhanced behavioral effects observed upon co-treatment with OXTR and D2R agonists may reflect the existence of improved positive receptor–receptor interactions in the putative D2R–OXTR heterocomplexes in certain neuronal populations of the basolateral and central amygdala. The D2R–OXTR heterocomplex, especially upon agonist co-activation in the central amygdala, may open a new pharmacological venue for the treatment of anxiety.
New Treatment Options for Refractory/Resistant CMV Infection
Authors: Walti Carla Simone , Khanna Nina , Avery Robin K. , Helanterä Ilkka 
Published: October 2023

Despite advances in monitoring and treatment, cytomegalovirus (CMV) infections remain one of the most common complications after solid organ transplantation (SOT). CMV infection may fail to respond to standard first- and second-line antiviral therapies with or without the presence of antiviral resistance to these therapies. This failure to respond after 14 days of appropriate treatment is referred to as “resistant/refractory CMV.” Limited data on refractory CMV without antiviral resistance are available. Reported rates of resistant CMV are up to 18% in SOT recipients treated for CMV. Therapeutic options for treating these infections are limited due to the toxicity of the agent used or transplant-related complications. This is often the challenge with conventional agents such as ganciclovir, foscarnet and cidofovir. Recent introduction of new CMV agents including maribavir and letermovir as well as the use of adoptive T cell therapy may improve the outcome of these difficult-to-treat infections in SOT recipients. In this expert review, we focus on new treatment options for resistant/refractory CMV infection and disease in SOT recipients, with an emphasis on maribavir, letermovir, and adoptive T cell therapy.
Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action
Authors: Valiulin Sergey V. , Onischuk Andrei A. , Pyryaeva Alexandra P. , An’kov Sergey V. , Baklanov Anatoly M. , Shkil Nikolay N. , Nefedova Ekaterina V. , Ershov Kirill S. , Tolstikova Tatyana G. , Dultseva Galina G. 
Published: October 2023

The aerosol inhalation delivery of composite particles consisting of Ag nanoparticles enveloped by polyvinylpyrrolidone was investigated in experiments with mice. An ultrasonic nebulizing system was created for the generation of aerosols with a mean diameter and mass concentration of 700 ± 50 nm and 65 ± 5 mg/m3, respectively. The mass fraction of Ag in the composite particles was α = 0.061. The aerosol delivery was performed in a whole-body chamber with an exposition time of 20 min. Pharmacokinetic measurements were taken and the silver concentrations in the blood and lungs of the mice were measured as a function of time after exposition by means of electrothermal (graphite furnace) atomic absorption spectrometry. The inhalation dose and other pharmacokinetic parameters were determined. The antibacterial effect of aerosolized silver was assessed for mice infected with Klebsiella pneumoniae 82 and Staphylococcus aureus ATCC 25953. The survival rate of the infected mice after the aerosol exposure demonstrated the high antibacterial efficiency of Ag nanoparticles after inhalation delivery.
Effect of a Wake-Field on the Dissociation of Quarkonium in Collisional Quark–Gluon Plasma
Authors: Kuanyshbaiuly Yernur , Junissov Ardak , Muratov Mukhit 
Published: October 2023

We have studied wake effects on the dissociation of heavy quarkonia states J/ψ and Y by introducing an in-medium modification to the inter-quark potential. The wakes in the quark–gluon plasma were modeled using linear response theory using a dynamic dielectric function obtained from kinetic theory (Boltzmann equation) with a Bhatnagar–Gross–Krook (BGK) collision term. The in-medium modified potential was used to investigate the dissociation character depending on various parameters such as the velocity of quarkonium moving through the medium and the collision frequency. We have also calculated critical values of the dissociation temperature. Modifications of the dissociation energy due to wake-field effects were found.
The effect of general practice team composition and climate on staff and patient experiences: a systematic review
Authors: Abrams Ruth , Jones Bridget , Campbell John , de Lusignan Simon , Peckham Stephen , Gage Heather 
Published: October 2023

BackgroundRecent policy initiatives seeking to address the workforce crisis in general practice have promoted greater multidisciplinarity. Evidence is lacking on how changes in staffing and the relational climate in practice teams affect the experiences of staff and patients.AimTo synthesise evidence on how the composition of the practice workforce and team climate affect staff job satisfaction and burnout, and the processes and quality of care for patients.Design & settingA systematic literature review of international evidence.MethodFour different searches were carried out using MEDLINE, Embase, Cochrane Library, CINAHL, PsycINFO, and Web of Science. Evidence from English language articles from 2012–2022 was identified, with no restriction on study design. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed and data were synthesised thematically.ResultsIn total, 11 studies in primary healthcare settings were included, 10 from US integrated healthcare systems, one from Canada. Findings indicated that when teams are understaffed and work environments are stressful, patient care and staff wellbeing suffer. However, a good relational climate can buffer against burnout and protect patient care quality in situations of high workload. Good team dynamics and stable team membership are important for patient care coordination and job satisfaction. Female physicians are at greater risk of burnout.ConclusionEvidence regarding team composition and team climate in relation to staff and patient outcomes in general practice remains limited. Challenges exist when drawing conclusions across different team compositions and definitions of team climate. Further research is needed to explore the conditions that generate a ‘good’ climate.
Une inscription funéraire chrétienne provenant de la chapelle Saint-Frambour à Ivry-sur-Seine (Val-de-Marne )
Authors: Ardouin Stéphane 
Published: October 2023

Les fouilles préventives menées entre 1988 et 1994 autour de la place Parmentier à Ivry-sur-Seine ont mis au jour une succession d’occupations depuis l’Âge du Fer. À l’époque mérovingienne, une nécropole s’installe sur les ruines de bâtiments du Bas Empire. Les inhumations s’y poursuivent durant le Moyen Âge. Au XIIe siècle est construite la chapelle Saint-Frambour, sur l’emplacement légendaire de l’ermitage de Frambaldus.
L’épitaphe chrétienne d’un enfant, datable selon toute vraisemblance entre la fin du IVe et le VIe siècle, gravée sur un élément d’architecture, permet de s’interroger sur l’éventualité de l’existence d’un sanctuaire chrétien, peut-être à l’origine de la chapelle. L’emplacement privilégié pour les inhumations, au sein des ruines antiques, pourrait indiquer la réutilisation de ces murs pour une chapelle funéraire. Les données issues de la fouille ne permettent pas de préciser la nature et l’importance de l’habitat avant la période carolingienne.
A segurança pública e os espaços educacionais: o papel da polícia no enfrentamento da violência
Authors: Vieira Airton Campos 
Published: October 2023

Há muito tempo a imprensa vem nos apontando uma série de desafios a serem rompidos, em razão do alto índice de violência nas escolas brasileiras, protagonizadas por atores externos que invadem o espaço escolar para o cometimento de crimes, ou ocorrências surgidas dentro da própria instituição, protagonizadas por atores internos. Neste sentido, o presente artigo busca refletir sobre esta realidade situacional da violência destes espaços da construção do conhecimento, a partir da inserção e representação social e simbólica principalmente dos Policiais nos espaços da comunidade escolar. Sob o aporte de fundamentos teóricos e dos próprios instrumentais legais preconizados na Constituição Federal, defende-se a tese, neste texto científico, de que a presença da Polícia em programas e ações projetadas em um ambiente de ecossistema comunicacional de aproximação entre as instituições, visando a ampliação da conscientização e diminuição das múltiplas manifestações de violências. Dessa forma fundamental trazer a baila a necessidade de reflexão sobre qual o rumo que está direcionando a educação, sob o ponto de vista da formação dos alunos como parte da sociedade.
ПІДГОТОВКА МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВИХ КЛАСІВ: МОЖЛИВОСТІ ЗАСОБІВ ФАСИЛІТАЦІЇ
Authors: Рябець Діана 
Published: October 2023

У статті проаналізовано методи фасилітації, які можна використовувати для навчання майбутніх педагогів. Обґрунтовано, що ефективність професійної підготовки визначається змістом освітніх програм і застосуванням активних методів навчання в роботі зі здобувачами вищої освіти. Наголошено, що особливої актуальності набувають методи фасилітації, потенціал яких сприяє актуалізації внутрішніх механізмів особистісного розвитку та самовдосконаленню майбутніх учителів. Визначено, що усі методи можна класифікувати в залежності від застосування на різних етапах роботи зі здобувачами освіти. Запропоновано класифікацію методів на етапі знайомства: вправи, спрямовані на повторення імені; вправи спрямовані на запам’ятовування імені за допомогою асоціації чи цікавого факту; вправи, які допомагають більше дізнатись один про одного. Методи на етапі очікувань поділено на такі групи: метафоричні, ґрунтовні, дієві, засновані на безпосередній взаємодії учасників. Детально розкрито зміст методів фасилітації, спрямованих на роботу з темою лекції. Розглянуто метод консенсусу, «Світове кафе», «Відкритий простір», «Позитивний конфлікт». Використання цих методів підвищує залученість і зацікавленість учасників в процесі і результаті групової роботи; збільшує швидкість і точність інформаційного обміну; розкриває потенціал кожного учасника; створює умови для генерації нових креативних ідей; приймає узгоджені управлінські рішення. Здійснено аналіз застосування методів на практиці, розглянуто переваги групової роботи та визначено ефективність методів фасилітації при підготовці майбутніх учителів початкових класів. Організація групової роботи за допомогою методів фасилітації сприяє інтеграції різних точок зору, розвитку вміння у майбутніх учителів початкових класів знайти вихід з найскладніших ситуацій.
Ключові слова: фасилітація; фасилітатор; методи фасилітації; учитель початкових класів.
Władza parlamentu do stanowienia i interpretowania prawa – kontrowersje wokół wykładni autentycznej ustaw
Authors: Stefaniuk Małgorzata Ewa 
Published: October 2023

CEL NAUKOWY: Celem artykułu jest przedstawienie kontrowersji wokół uprawnienia władzy ustawodawczej do dokonywania wykładni autentycznej w warunkach demokratycznego państwa prawnego i obowiązywania konstytucyjnych zasad: podziału władzy i legalizmu.
PROBLEM I METODY BADAWCZE: W artykule postawiono następujące pytania: Czy argumenty na poparcie tezy o niedopuszczalności wykładni autentycznej ze względu na jej sprzeczność z zasadą podziału władzy i zasadą legalizmu są dostatecznie przekonywujące? Czy parlament może dokonywać interpretacji tworzonego przez siebie prawa za pomocą innych konstrukcji prawnych? W artykule zastosowano metodę analizy literatury przedmiotu, orzecznictwa sądowego oraz analizę dogmatyczno-prawną i metodę porównawczą.
PROCES WYWODU: Zaprezentowano istotę wykładni autentycznej, by następnie przejść do wykładni autentycznej ustaw. Dokonano krytycznej analizy argumentów podnoszonych przeciwko zasadności funkcjonowania wykładni autentycznej w demokratycznym państwie prawnym. Przedstawione zostały również konstrukcje prawne uważane za postaci wykładni autentycznej ustaw.
WYNIKI ANALIZY NAUKOWEJ: Podnoszona współcześnie sprzeczność wykładni autentycznej z zasadą podziału władzy i zasadą legalizmu nie jest dostatecznie przekonywująca. Wydaje się, że jako postaci wykładni autentycznej mogą występować definicje legalne, preambuły i uzasadnienia projektów ustaw, chociaż niektórzy autorzy opracowań stoją na stanowisku, iż nie należy tych konstrukcji prawnych łączyć z pojęciem wykładni autentycznej.
WNIOSKI, INNOWACJE, REKOMENDACJE: Problematyka wykładni autentycznej generuje wiele interesujących kwestii również w relacjach teorii prawa z dogmatyką prawa czy teorii prawa i orzecznictwa. To, czy definicje legalne, preambuły i materiały legislacyjne są postaciami wykładni autentycznej, zależy od przyjętych założeń badawczych.
Genesis and key elements of the mechanism of digital transformation of industrial enterprises
Authors: Gileva T. A. , Khussamov R. R. 
Published: October 2023

Aim. To study the peculiarities of different approaches to the construction of the mechanism of digital transformation of industrial enterprises and to identify the key elements, the creation and (or) development of which is necessary for the realisation of successful digital transformation.Tasks. To study the Russian and world experience in the field of building the mechanism of digital transformation of enterprises; to generalise and systematise various approaches; to form an integral set of key elements, the transformation of which is necessary to ensure competitiveness in the digital environment.Methods. The subject of the study are mechanisms, models and methods of digital transformation of enterprises developed by large global and Russian companies, mainly consulting companies. The analysis takes into account the presence of a clear system of principles (priorities), substantive aspects, structuring of various mechanisms by stages and elements of digital transformation, the level of specificity of proposed solutions, as well as additional features (for example, the presence of a model for assessing the digital maturity of the enterprise).Results. The key elements of the mechanism of digital transformation of an industrial enterprise are identified: digital strategy, business model, digital core and digital technologies, operating model, people and organisational culture, orchestration. It is shown that when developing a digital strategy, it is necessary to maximise the use of the enterprise’s competitive advantages (e.g., developed partner network, unique equipment and technologies, a wide range of goods and services, customer databases, etc.), as well as ecosystem opportunities. To increase the flexibility of the strategy, it is proposed to focus on the concept of strategic priorities. Emphasis is placed on the importance of aligning digital strategy with the operating model of an industrial enterprise. As a promising direction of digital transformation, the creation of a “digital core” of the enterprise, which unites all information systems, applications, services and data through the cloud in order to integrate technological and organisational aspects of digital transformation across the entire value chain, including partners and customers, is highlighted.Conclusions. The presented developments can serve as a reference point for managers of industrial enterprises developing and implementing digital transformation programmes.
Assessment of managers of digital transformation in the regions as a factor of strategic management of sustainable ESG development of the economy
Authors: Babkin A. V. , Egorov N. E. 
Published: October 2023

Aim. To conduct a rating assessment of digital transformation managers (DTM), as well as to identify the relationship between the DTM score and indicators of gross regional product (GRP), budget expenditures on information and communication technologies (ICT) in the conditions of sustainable ESG-development of the economy.Tasks. To show that in modern conditions one of the most important factors in the formation of the digital economy of regions and their digital transformation is the strategic management of sustainable ESG-development of economic entities; to perform a rating assessment of the level of RCT of regions and establish its dependence on GRP and ICT-costs; to offer practical recommendations to the criteria for assessing RCT.Methods. The research is based on the application of standard methods of collecting and processing statistical data from open sources and correlation analysis.Results. In modern conditions, one of the most important factors in the formation of digital economy of regions and their digital transformation is the strategic management of sustainable ESG-development of economic entities. The necessity to develop a strategy of digital transformation of the region’s economic model, which should be based on strategic management of sustainable ESG-development of cyber-physical and cyber-social enterprises and ecosystems, including cluster-type. It is shown that at the end of 2022 the leading places in the RCT rating among all subjects of the Russian Federation (RF) are occupied by Tatarstan, Belgorod, Tula regions and Khanty-Mansi Autonomous Okrug. In 2021, significant amounts of budget funds for ICTcosts, compared to other subjects of the Russian Federation, are allocated in megacities — Moscow and St. Petersburg. A linear correlation between the level of RCT and GRP indicators, budget expenditures on ICT was established. A significant influence of the criterion “IT industry support measures” on the assessment of responsible RCT in the regions was revealed.Conclusions. Under the conditions of economic sanctions, including restrictions on the supply of high-tech products, the processes of modernization in the field of digital technologies and accelerated implementation of software import substitution will be reflected in further assessments of RCTs of federal ministries and constituent entities of the Russian Federation. It is recommended to take into account the ESG-development indicators of economic entities and the level of professional training in the field of digital technologies in the criteria for rating RCTs.
Objective limitations of the current vector of ESG-transition development
Authors: Denisov M. V. 
Published: October 2023

Aim. To identify objective reasons for the slowdown of ESG-transition, as well as a list of risks and limitations of the current vector of development of the climate agenda, which are often ignored by developers of “green” standards and taxonomies.Tasks. To evaluate ESG transition initiatives during the COVID-19 coronavirus pandemic; to identify non-obvious barriers and constraints to ESG transition; and to uncover the reasons that have shaped the current vector of the climate agenda.Methods. The study is based on the analysis of empirical data. Their processing showed that ideas of the international climate agenda are often broadcast regarding the ESG topic, but there are very few critical articles and reviews about it.Results. The current vector of development of the climate agenda is primarily conditioned by the goals of its initiators - international economic organizations. These include the Organization for Economic Cooperation and Development (OECD), the International Monetary Fund (IMF) and the World Trade Organization (WTO). The propagated notions of global environmental crises that future generations will inevitably face unless measures are taken to facilitate the transition to sustainable development are only a political tool for competing in the hydrocarbon market. Given the lack of strong technological solutions, investments in green assets can be seen as high-risk given their speculative nature.Conclusions. Despite the priorities of the global economic agenda, there are doubts about its integrity, as it fails to take into account a number of constraints and circumstances, including failure to take into account the scale of the raw material strain required to transform the global energy system; the lack of technologies to efficiently process large volumes of retired so-called renewable energy sources; the lack of energy technologies for which demand is not yet evident; and the “rebound” effect, i.e. the question of what happens next. As a result, market participants often use so-called greenwashing (or “green camouflage”) to formally meet the requirements, or rather, to portray the “greenness” of their technology/products.
On the impact of sanctions on the financial sovereignty of Russia and the formation of its model
Authors: Sintsova E. A. , Zvyagina E. M. 
Published: October 2023

Aim.To identify the key stages of sanctions pressure on Russia and the formation of the financial sovereignty model.Tasks.To identify the main stages of sanctions pressure on the Russian economy; to identify general regularities and key stages of sanctions against the Russian Federation (RF); to develop a functional model of Russia’s financial sovereignty.Methods.In the present study with the application of general scientific methods, as well as systemic and comparative approaches, statistical analysis, the peculiarities of formation and establishment of financial sovereignty of Russia are considered.Results.The stages of sanctions pressure on Russia are systematized. It is shown that the most important prerequisite for the creation of financial sovereignty were the sanctions imposed on Russia. The conclusion about the impact of sanctions on the domestic economy is substantiated. It is shown that the components of financial sovereignty form a functional model with feedback, and this determines the possibilities for further research. The results of this study can be used to develop new approaches to the formation of financial sovereignty in Russia, to improve the efficiency of interaction of elements in the system.Conclusions.The main drivers of the formation of financial sovereignty were the sanctions imposed against the Russian Federation. At the same time, the impact of sanctions will be weakened due to the financial policy of the state.