bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel metabolism-related gene signature in patients with hepatocellular carcinoma
Authors: Ru Bin , Hu Jiaqi , Zhang Nannan , Wan Quan 
Published: November 2023

Hepatocellular carcinoma (HCC) remains a global challenge as it is the sixth most common neoplasm worldwide and the third leading cause of cancer-related death. A key feature of HCC is abnormal metabolism, which promotes cancer cell proliferation, survival, invasion, and metastasis. However, the significance of metabolism-related genes (MRGs) in HCC remains to be elucidated. Here, we aim to establish a novel metabolism-related prognostic signature for the prediction of patient outcomes and to investigate the value of MRG expression in the prognostic prediction of HCC. In our research, a Metabolism-Related Risk Score (MRRS) model was constructed using 14 MRGs (DLAT, SEPHS1, ACADS, UCK2, GOT2, ADH4, LDHA, ME1, TXNRD1, B4GALT2, AK2, PTDSS2, CSAD, and AMD1). The Kaplan-Meier curve confirmed that the MRRS has a high accuracy in predicting the prognosis of HCC patients (p < 0.001). According to the MRRS model, the area under the curve (AUC) values for predicting the prognosis of patients with hepatocellular carcinoma at 1, 3, and 5 years reached 0.829, 0.760, and 0.739, respectively. Functional analyses revealed that signaling pathways associated with the cell cycle were largely enriched by differential genes between high and low-risk groups. In addition, dendritic cells (DCs) (p < 0.001), CD4+ T cells (p < 0.01), CD8+ T cells (p < 0.001), B cells (p < 0.001), neutrophils (p < 0.001), macrophages (p < 0.001) had a higher proportion of infiltrates in high-risk populations. Low GOT2 expression is associated with poor prognosis in patients with hepatocellular carcinoma. Knockdown of GOT2 significantly increased the migration capacity of the Huh7 and MHCC97H hepatocellular carcinoma lines. Our research reveals that GOT2 is negatively related to the survival of patients with hepatocellular carcinoma and GOT2 may contribute to tumor progression by inhibiting the ability of tumor cells to migrate.
Construction and application of milk-feed price ratio model - based on data from large scale dairy farms in China
Authors: Liu Hao , Peng Hua , Zhang Chao , Dong Xiaoxia 
Published: November 2023

Despite rapid development, the Chinese dairy industry still faces problems such as the lack of pricing power for dairy farmers, high fluctuations in raw milk and feed prices, imbalances between supply and demand, and low farming motivation. As an indicator with important geographical characteristics, the milk-feed price ratio (MF) is a critical reference indicator for setting raw milk prices and measuring farm profitability. The main aim of this study is to construct an appropriate milk-feed ratio model for China using statistical data for 2018-2020, which provides references for other developing countries. A vector error correction model was used to illustrate the long-term covariance between raw milk prices and feed prices in China and to analyze the feed structure of large-scale Chinese farms. The study found that the price weights of corn, soybean meal, corn silage, and alfalfa were 27%, 17%, 30%, and 26%, respectively, which are significantly different from those of developed countries, and the parameters of the model for the MF in different production areas in China also varied significantly. The milk-feed ratio in China has remained above 1.89 in the last three years. Seasonal variations in raw milk prices lead to a U-shaped trend in the MF. In recent years the MF in China has changed from a low level to a medium level, showing an upward trend, with large-scale farms at a profitable level.
Keywords: Application of MF; Granger causality test; MF model; Large scale farm
Microwave-assisted puffing of Dendrobium officinale for higher extraction rate of polysaccharides
Authors: Li Yanhong , Wang Zuoqiang , Li Tingting , Bai Xishan , Tian Kai , Huang Xiangzhong 
Published: November 2023

In order to increase the extraction rate of Dendrobium officinale polysaccharides, microwave puffing was used to process its fresh stems and the processing parameters were optimized. Response surface methodology was used to analyze the effects of sample length (1–5cm), moisture content (15%–25%), microwave power (550–790 W), and microwave processing time (20–40 s) on the expansion ratio. The results showed that the optimized expansion ratio of 371.7% was achieved at the following conditions, i.e., sample length of 3.5 cm, moisture content of 23%, microwave power of 706 W, and processing time of 35 s. It was found that polysaccharides were extracted more readily from puffed D. officinale than from non-puffed D. officinale by 41.8%. Moreover, the bioactivities of polysaccharides from puffing D. officinale and non-puffing D. officinale were evaluated and compared in lipid peroxidation inhibition and anti-hyperglycemic assays.
Keywords: Dendrobium officinale; Microwave puffing; Polysaccharides; Lipid peroxidation; Anti-hyperglycemic activity
Rejoint of Carbon Nitride Fragments into Multi‐Interfacial Order‐Disorder Homojunction for Robust Photo‐Driven Generation of H2O2
Authors: He Fengting , Lu Yangming , Wu Yuzhao , Wang Shuling , Zhang Yang , Dong Pei , Wang Yongqiang , Zhao Chaocheng , Wang Shuaijun , Zhang Jinqiang , Wang Shaobin 
Published: November 2023

AbstractPhotocatalytic technology based on carbon nitride (C3N4) offers a sustainable and clean approach for hydrogen peroxide (H2O2) production, but the yield is severely limited by the sluggish hot carriers due to the weak internal electric field. In this study, a novel approach is devised by fragmenting bulk C3N4 into smaller pieces (CN‐NH4) and then subjecting it to a directed healing process to create multiple order‐disorder interfaces (CN‐NH4‐NaK). The resulting junctions in CN‐NH4‐NaK significantly boost charge dynamics and facilitate more spatially and orderly separated redox centers. As a result, CN‐NH4‐NaK demonstrates outstanding photosynthesis of H2O2 via both two‐step single‐electron and one‐step double‐electron oxygen reduction pathways, achieving a remarkable yield of 16675 µmol h–1 g–1, excellent selectivity (> 91%), and a prominent solar‐to‐chemical conversion efficiency exceeding 2.3%. These remarkable results surpass pristine C3N4 by 158 times and outperform previously reported C3N4‐based photocatalysts. This work represents a significant advancement in catalyst design and modification technology, inspiring the development of more efficient metal‐free photocatalysts for the synthesis of highly valued fuels.
Ni Single‐Atoms Based Memristors with Ultrafast Speed and Ultralong Data Retention
Authors: Li Hua‐Xin , Li Qing‐Xiu , Li Fu‐Zhi , Liu Jia‐Peng , Gong Guo‐Dong , Zhang Yu‐Qi , Leng Yan‐Bing , Sun Tao , Zhou Ye , Han Su‐Ting 
Published: November 2023

AbstractMemristor with low‐power, high density, and scalability fulfills the requirements of the applications of the new computing system beyond Moore's law. However, there are still nonideal device characteristics observed in the memristor to be solved. The important observation is that retention and speed are correlated parameters of memristor with trade off against each other. The delicately modulating distribution and trapping level of defects in electron migration‐based memristor is expected to provide a compromise method to address the contradictory issue of improving both switching speed and retention capability. Here, high‐performance memristor based on the structure of ITO/Ni single‐atoms (NiSAs/N‐C)/Polyvinyl pyrrolidone (PVP)/Au is reported. By utilizing well‐distributed trapping sites , small tunneling barriers/distance and high charging energy, the memristor with an ultrafast switching speed of 100 ns, ultralong retention capability of 106 s, a low set voltage (Vset) of ≈0.7 V, a substantial ON/OFF ration of 103, and low spatial variation in cycle‐to‐cycle (500 cycles) and device‐to‐device characteristics (128 devices) is demonstrated. On the premise of preserving the strengths of a fast switching speed, this memristor exhibits ultralong retention capability comparable to the commercialized flash memory. Finally, a memristor ratioed logic‐based combinational memristor array to realize the one‐bit full adder is further implemented.
A Clean, Rapid, and Controllable Approach for Establishing Bioactive Surfaces on Zirconia Implants
Authors: Chen Chengxin , Cheng Qi , Han Yu , Wang Ran , Kong Dejian , Chen Xiaojing , Zhu Yuanjing , Lu Yanxu , Zhou Hongbo 
Published: November 2023

AbstractZirconia implants have great application prospects due to their favorable biocompatibility and esthetic properties. However, the percentage of osseointegration of zirconia implants is lower than that of titanium implants. This study, structures bioactive surfaces on zirconia using a femtosecond laser combined with hydroxyapatite (HA) crystals and evaluates the surface morphology, functional groups, crystal phase, mechanical performance, and cell response. The results revealed that calcium phosphate deposition coincided with the establishment of micro‐grooves on the zirconia surface. The crystal composition and flexural strength of zirconia showed no significant changes after the surface treatment. Furthermore, the modified surface promoted cell adhesion and proliferation through adjustments in cell morphology. The findings suggest that the combination of femtosecond laser and HA crystals offers a clean, rapid, and controllable approach to preparing bioactive surfaces for zirconia implants.
Lone‐Pair‐Driven, Brightly Emitting Lead‐Free Zero‐Dimensional Inorganic Luminescent Member
Authors: Viswanath Noolu Srinivasa Manikanta , Samanta Tuhin , Yoon Yeongjun , Jang Sung Woo , Kim Kyeounghak , Im Won Bin 
Published: November 2023

AbstractZero‐dimensional (0D) 5s2‐metal halide (MH) materials offer potential for use in solid‐state lighting, optical thermography, and scintillation applications. The organic components of most highly luminescent materials are inherently unstable under moisture and thermal stress, which restricts their practical use in advanced applications. Hence, highly luminescent and stable inorganic luminescent materials are required. In this work, to the best of current knowledge, a 0D completely inorganic luminescent member of K2SbCl5 that exhibits orange emission at 610 nm with an 80% photoluminescence quantum yield (PLQY) is reported for the first time. Density functional theory calculations reveal that the [SbCl5]2‐ square pyramidal units are the only optically active emission centers in K2SbCl5. The white light‐emitting device utilizing K2SbCl5 demonstrates impressive performance metrics, boasting a substantial color rendering index (CRI) of 94 and an exceptional luminous efficacy of 118.1 lm W−1. Hence, this isolated [SbCl5]2−square pyramidal environment serves as a design principle for the development of highly efficient inorganic Sb3+‐based luminescent materials for future optoelectronic applications.
Relationships among sporophytic and gametophytic traits of 27 subtropical montane moss species
Authors: He Yunyu , Bader Maaike Y. , Li Dandan , Stark Lloyd R. , Li Xiaoming , Liu Xin , Yuan Qizhang , Guo Shuiliang , Fang Zhiqiang , Wang Zhe 
Published: November 2023

AbstractPremiseMoss sporophytes differ strongly in size and biomass partitioning, potentially reflecting reproductive and dispersal strategies. Understanding how sporophyte traits are coordinated is essential for understanding moss functioning and evolution. This study aimed to answer: (1) how the size and proportions of the sporophyte differ between moss species with and without a prominent central strand in the seta, (2) how anatomical and morphological traits of the seta are related, and (3) how sporophytic biomass relates to gametophytic biomass and nutrient concentrations.MethodsWe studied the relationships between seta anatomical and morphological traits, the biomass of seta, capsule, and gametophyte, and carbon, nitrogen, and phosphorus concentrations of 27 subtropical montane moss species.Results(1) Moss species with a prominent central strand in the seta had larger setae and heavier capsules than those without a prominent strand. (2) With increasing seta length, setae became thicker and more rounded for both groups, while in species with a prominent central strand, the ratio of transport‐cell area to epidermal area decreased. (3) In both groups, mosses with greater gametophytic biomass tended to have heavier sporophytes, but nitrogen and phosphorus concentrations in the gametophyte were unrelated to sporophytic traits.ConclusionsOur study highlights that the central strand in the seta may have an important functional role and affect the allometry of moss sporophytes. The coordinated variations in sporophyte morphological and anatomical traits follow basic biomechanical principles of cylinder‐like structures, and these traits relate only weakly to the gametophytic nutrient concentrations. Research on moss sporophyte functional traits and their relationships to gametophytes is still in its infancy but could provide important insights into their adaptative strategies.
A Phosphine‐Amine‐Linked Covalent Organic Framework with Staggered Stacking Structure for Lithium‐Ion Conduction
Authors: Tan Jing , Weng Weijun , Zhu Jinyao , Liu Shujing , Xu Jie , An Shuhao , Wang Changchun , Guo Jia 
Published: November 2023

AbstractIn‐plane ionic conduction over two‐dimensional (2D) materials is desirable for flexible electronics. Exfoliating 2D covalent organic frameworks (COFs) towards a few layers is highly anticipated, whereas most examples remain robust via π‐stacking against the interlayered dislocation. Herein, we synthesize a phosphine‐amine‐linked 2D COF by a nucleophilic substitution reaction of phosphazene with amines. The synthesized COF is crystalline, and stacks in an AB‐staggered fashion, wherein the AB dual layers are interlocked by embedding P−Cl bonds from one to another layer, and the non‐interlocked layers are readily delaminated. Therefore, in situ post‐quaternization over phosphazene can improve the ionization of backbones, accompanied by layered exfoliation. The ultrathin nanosheets can decouple lithium salts for fast solid‐state ion transport, achieving a high conductivity and low activation energy. Our findings explore the P−N substitution reaction for COF crystallization and demonstrate that the staggered stacking 2D COFs are readily exfoliated for designing solid electrolytes.
Uncovering a CF3 Effect on X‐ray Absorption Energies of [Cu(CF3)4]− and Related Copper Compounds by Using Resonant Diffraction Anomalous Fine Structure (DAFS) Measurements**
Authors: Alayoglu Pinar , Chang Tieyan , Yan Connly , Chen Yu‐Sheng , Mankad Neal P. 
Published: November 2023

AbstractUnderstanding the electronic structures of high‐valent metal complexes aids the advancement of metal‐catalyzed cross coupling methodologies. A prototypical complex with formally high valency is [Cu(CF3)4]− (1), which has a formal Cu(III) oxidation state but whose physical analysis has led some to a Cu(I) assignment in an inverted ligand field model. Recent examinations of 1 by X‐ray spectroscopies have led previous authors to contradictory conclusions, motivating the re‐examination of its X‐ray absorption profile here by a complementary method, resonant diffraction anomalous fine structure (DAFS). From analysis of DAFS measurements for a series of seven mononuclear Cu complexes including 1, here it is shown that there is a systematic trifluoromethyl effect on X‐ray absorption that blue shifts the resonant Cu K‐edge energy by 2–3 eV per CF3, completely accounting for observed changes in DAFS profiles between formally Cu(III) complexes like 1 and formally Cu(I) complexes like (Ph3P)3CuCF3 (3). Thus, in agreement with the inverted ligand field model, the data presented herein imply that 1 is best described as containing a Cu(I) ion with dn count approaching 10.
CZTS (Cu2ZnSnS4)‐based Nanomaterials in Photocatalytic and Hydrogen Production Applications: A Recent Progress towards Sustainable Environment
Authors: Tanaya Das Himadri , Dutta Swapnamoy , Gaurav Kumar , Kanti Giri Arnab , Mondal Aniruddha , Kumar Jena Rajesh , Das Nigamananda 
Published: November 2023

AbstractA variety of unique compounds have been examined to accommodate the current demand for useful multi‐functional nanomaterials, copper‐based quaternary CZTS semiconductors are one of them. Due to their special characteristic features like non‐toxicity, cheap, and abundance, they have been recommended in recent literature for various applications. Apart from individual CZTS, different hetero‐structures have also been prepared with different compounds which is well discussed and elaborated in this article. Additionally, their preparation methods, properties, and application viability have also been discussed comprehensively. The application of CZTS such as photocatalytic dye degradation and hydrogen evolution reaction has been elaborated on in this article identifying their benefits and challenges to give readers a thorough visualization. Apart from that, challenges reported in studies, a few approaches are also mentioned to possibly counter them.
Clinical utility of the standardized observation tool Autism Behavior Coding System for early intervention research in autism spectrum disorder
Authors: Spiegel René , Notter Marianne , Lazari Olga , Schmeck Klaus , Herbrecht Evelyn 
Published: November 2023

AbstractThe Autism Behavior Coding System (ABCS) was developed to help evaluating the effectiveness of early intensive interventions in children with autism spectrum disorder (ASD). The video‐based ABCS assesses eight core autistic behavioral variables during therapist‐child interaction using standardized quantitative criteria, four behaviors according to their frequency of occurrence, four according to their duration. The present study focuses (1) on the correspondence of ABCS scores with scores on two standard clinical instruments (the ADOS‐2 and an ASD‐adaptation of the Children's Global Assessment Scale, DD‐CGAS), (2) on the sensitivity to change of ABCS scores by the end of an intensive 18 days intervention period (EIP) and (c) on the predictability of short‐ and longer‐term changes in social and repetitive behaviors from ABCS scores at baseline and EIP. Data from 51 children (42 M, 9 F; median age 45 months) followed over 1 year were available. There were significant correlations at baseline between several ABCS scores and ADOS‐2 as well as DD‐CGAS scores. Correlations at EIP between some ABCS and DD‐CGAS scores were highly significant. Four ABCS scores reflected significant changes from baseline to EIP. Several baseline ABCS scores were predictive of DD‐CGAS and ADOS‐2 scores at EIP and Year 1. However, associations between ABCS score changes from baseline to EIP and the clinical scale changes by Year 1 were not significant. It is concluded that several ABCS scores have adequate clinical validity and sensitivity to change. The short‐term changes in ABCS scores and their relationship to longer‐term clinical changes need further study.
Self‐assembly of PEG–PPS polymers and LL‐37 peptide nanomicelles improves the oxidative microenvironment and promotes angiogenesis to facilitate chronic wound healing
Authors: Shi Rong , Qiao Jianxiong , Sun Quanwu , Hou Biao , Li Bo , Zheng Ji , Zhang Zhenzhen , Peng Zhenxue , Zhou Jing , Shen Bingbing , Deng Jun , Zhang Xuanfen 
Published: November 2023

AbstractRefractory diabetic wounds are associated with high incidence, mortality, and recurrence rates and are a devastating and rapidly growing clinical problem. However, treating these wounds is difficult owing to uncontrolled inflammatory microenvironments and defective angiogenesis in the affected areas, with no established effective treatment to the best of our knowledge. Herein, we optimized a dual functional therapeutic agent based on the assembly of LL‐37 peptides and diblock copolymer poly(ethylene glycol)–poly(propylene sulfide) (PEG–PPS). The incorporation of PEG–PPS enabled responsive or controlled LL‐37 peptide release in the presence of reactive oxygen species (ROS). LL‐37@PEG–PPS nanomicelles not only scavenged excessive ROS to improve the microenvironment for angiogenesis but also released LL‐37 peptides and protected them from degradation, thereby robustly increasing angiogenesis. Diabetic wounds treated with LL‐37@PEG–PPS exhibited accelerated and high‐quality wound healing in vivo. This study shows that LL‐37@PEG–PPS can restore beneficial angiogenesis in the wound microenvironment by continuously providing angiogenesis‐promoting signals. Thus, it may be a promising drug for improving chronic refractory wound healing.
Understanding caregivers' decision to vaccinate childhood cancer survivors against COVID‐19
Authors: Ilic Anica , Haardoerfer Regine , Michel Gisela , Escoffery Cam , Mertens Ann C. , Marchak Jordan Gilleland 
Published: November 2023

AbstractBackgroundVaccination against COVID‐19 is recommended for childhood cancer survivors (CCS). This study aimed to identify antecedents contributing to caregivers' decisions to vaccinate CCS aged 5–17 years against COVID‐19 by applying the Theory of Planned Behavior.MethodsParticipants in this cross‐sectional study completed an online survey assessing caregiver attitudes, subjective norms, perceived behavioral control, intention to vaccinate CCS, CCS vaccination status, COVID‐19 health literacy, and frequency of COVID‐19 information‐seeking. Surveys were completed between May and June 2022 following approval for the emergency use of COVID‐19 vaccines among children aged ≥5 years in the U.S. Data were analyzed using unadjusted linear regressions and structural equation modeling.ResultsParticipants were caregivers (n = 160, 87.5% biological mothers, 75.6% white/non‐Hispanic) of CCS (n = 160, 44.4% female, mean (M) = 12.5 years old, M = 8.0 years off treatment). 70.0% (n = 112) of caregivers and 53.8% (n = 86) of CCS received a COVID‐19 vaccine. Over one‐third (37.5%) of caregivers reported disagreement or indecision about future COVID‐19 vaccination for the CCS. Caregivers' intention (β = 0.962; standard error [S.E.] = 0.028; p < 0.001) was highly related to CCS vaccination status. Attitudes (β = 0.568; S.E. = 0.078; p < 0.001) and subjective norms (β = 0.322; S.E. = 0.062; p < 0.001) were associated with intention. Higher frequency of COVID‐19 information‐seeking (β = 0.313; S.E. = 0.063; p < 0.001) and COVID‐19 health literacy (β = 0.234; S.E. = 0.059; p < 0.001) had a positive indirect effect on intention through attitudes and subjective norms.ConclusionsCaregivers' vaccination intentions for minor CCS are highly related to vaccination behavior and shaped by attitudes, subjective norms, COVID‐19 health literacy, and frequency of COVID‐19 information‐seeking. Promoting tailored communication with caregivers of CCS and encouraging them to review reputable sources of information can address their vaccine hesitancy.