bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS TINGKAT ANCAMAN LONGSOR DI DISTRIK RANSIKI KABUPATEN MANOKWARI SELATAN
Authors: Alzair Nur , Mayzarah Erikha Maurizka 
Published: February 2024

Pemetaan tingkat ancaman longsor merupakan salah satu kegiatan yang penting manajemen risiko bencana longsor. Tujuan dari penelitian ini adalah memetakan tingkat ancaman longsor pada Distrik Ransiki. Penelitian ini dilakukan selama 6 bulan yaitu dari bulan Mei hingga bulan November 2021 di Distrik Ransiki, Kabupaten Manokwari Selatan, Provinsi Papua Barat. Metode. Parameter yang digunakan dalam penelitian ini yaitu Litologi, Struktur Geologi, Curah Hujan, tata Guna Lahan, dan Kemiringan Lereng. Metode yang digunakan yaitu metode tumpeng susun dimana untuk pembobotan parameter menggunakan Metode analytical hierarchy process (AHP). AHP ini digunakan untuk penentuan bobot dari setiap kelas parameter dan parameter bencana longsor. Pemetaan tingkat ancaman longsor dilakukan dengan menggunakan perangkat lunak ArcGIS 10.1. Hasil Peneltiannya yaitu terdapat 3 tingkat ancaman bencana longsor di Distrik Ransiki, Kabupaten Manokwari Selatan. Tingkat Ancaman rendah memiliki luasan 6.792,06 Hektar atau 37,52% dari total luasan Distrik Ransiki. Tingkat Ancaman Sedang seluas 6.741,33 Hektar atau 37,24% dari total luas wilayah Distrik Ransiki. Tingkat Ancaman Tinggi sebesar 4.567,85 Hektar atau Sekitar 25,24% dari total luas wilayah Distrik Ransiki. Saran dari penelitian ini adalah pada daerah dengan tingkat ancaman sedang dan tinggi dapat dilakukan penelitian lebih lanjut guna meminimalisir dampak dan kerugian yang akan disebabkan oleh longsor.
Infantile Myofibromatosis of the Femoral Neck
Authors: Gunderson Ashlynn , Abraham Vivek M. , Li Alexander D. , Lorimer Shannon D. , Rocchi Vanna 
Published: February 2024

Case:
A 15-month-old boy who was being followed for developmental dysplasia of the hip because of breech presentation was discovered to have a solitary infantile myofibroma in the left femoral neck. The patient was avoiding weight-bearing on the affected extremity; thus, stabilization of the femoral neck was performed using a proximal femur locking plate. Postoperatively, he achieved all gross motor developmental milestones.

Conclusion:
This report is the first to describe a solitary infantile myofibroma in the femoral neck and demonstrates the utility of operative stabilization of these lesions.
Reverse Shoulder Arthroplasty for Irreparable Rotator Cuff Tear After Radial to Axillary End-to-Side Transfer
Authors: Protzuk Omar , Schmidt R. Cole , Craig Justin M. , Weber Matt , Isaacs Jonathan , O’Connell Robert 
Published: February 2024

Case:
A 60-year-old man sustained a massive irreparable rotator cuff tear and axillary nerve palsy with deltoid dysfunction after an anterior shoulder dislocation. He underwent staged reverse end-to-side radial-to-axillary nerve transfer with return of deltoid function allowing for subsequent reverse shoulder arthroplasty. At 1 year postoperatively, he returned to full activity.

Conclusion:
Irreparable rotator cuff tears complicated by axillary nerve palsy can be effectively treated with a staged approach of nerve transfer followed by reverse shoulder arthroplasty.
A Rare Case of Awkward Gait
Authors: Feyder Cathy , Lejeune Gauthier , Rondia Jean , Vande Berg Bruno , Allington Nanni 
Published: February 2024

Case:
A young girl without pertinent medical history presented with a leg length discrepancy and an awkward gait disturbance. After a rapid growth spurt during the following year, other symptoms became obvious, she developed an inability to sit crossed legged, and her range of motion of the left hip decreased. Hip magnetic resonance imaging demonstrated a left unilateral fibrous band between the iliac wing and the greater trochanter.

Conclusion:
A fibrous band is a rare cause of leg length discrepancy and gait disturbance. The gait and hip movement improved after excision of the band.
Feature Selection and mRNA-miRNA bipartite Network Analysis for Biomarker Development and Drug Repurposing in Colon Cancer
Authors: Zavarzadeh Parisima Ghaffarian , Abedi Zahra , Abbasi Amirreza , MotieGhader Habib , Masoudi-Nejad Ali 
Published: February 2024

Abstract
Background: Colon cancer (CC) is the second cause of mortality among other non-skin cancers. Despite the progression in screening and diagnostic strategies, further information is still demanding for diagnosing, managing, and treating CC. In order to achieve this goal, computational analysis, including data mining algorithms are essential tools and the most widely used approach for achieving important features of gene expression data combined with clinical assessments which paves the way for diagnosis and treatment at the right time.
Methods: This study aimed to identify the most critical genes and candidate drugs that may be helpful for CC treatment and develop novel microRNA biomarkers for CC. The gene expression data from CC tissues, including 98 CC and 98 normal samples, were used to reconstruct gene co-expression networks. Deferentially expressed genes (DEGs) were extracted after preprocessing and normalization. Then, DEGs were used to construct the weighted gene co-expression network (WGCNA), and low-preserved modules were obtained. The experimentally validated mRNA-miRNA interaction information was used to construct three bipartite mRNA-miRNA networks. From each bipartite network, ten hub miRNAs were extracted for further analysis. Finally, a drug-gene interaction network was constructed.
Results: The most significant genes were ADH1B, AQP8, CA1, CLCA4, GUCA2B, MMP7, MS4A12, and TMIGD1 obtained from feature selection. The data included novel miRNAs (e.g., hsa-miR-665, hsa-miR-30c-3p, hsa-let-7b-5p, hsa-miR-3689d, hsa-miR-1233-5p, hsa-miR-1910-3p, and finally hsa-miR-6788-5p which was thoroughly novel without any investigation in other cancers) and might be potentially associated with CC. Also, the most important genes were targets for these miRNAs. Eventually, drugs such as Cytarabine, Levodopa, Methyldopa, Tretinoin, Hydralazine, Daunorubicin Hydrochloride, Olanzapine, and Idarubicin were proposed as potential novel drugs for CC treatment.
Conclusion: The present study was performed to determine the most significant genes, develop biomarkers, and find novel potential drugs for colon cancer. All potential biomarkers and drugs obtained from this study could be practical after extensive experimental studies for using them in clinical experiments.
Waterless production of cellulose nanofibrils adopting DBD oxygen plasma
Authors: Dimic-Misic katarina , Obradovic Bratislav , Kuraica Milorad , Kostic Mirjana , Le Huy Quang , Korica Matea , Imani Monireh , Gane Patrick 
Published: February 2024

Abstract
Cellulose is a strong contender to become a raw material which can enable the development of new sustainably resourced biodegradable materials composites supporting circular economy. Almost limitless possibilities exist for functionalising the cellulose molecule via the highly reactive hydroxyl groups enabling easy modification of the material surface, leading to the generation of tailored compatibility with a wide variety of industrial applications. Cellulose nanofibrils (CNF) are one of the most promising such lignocellulose derivatives. Currently, their production capacity and economy are hindered by high chemical and energy consumption, the latter primarily during mechanical fibrillation of native fibre in aqueous suspension, and the negative limitation of very low solids content associated with the gel-like properties of the resulting final product. Eliminating the need for liquid water during process treatment could, therefore, be transformative in respect to production feasibility, end-product transportation and application. The work reported here illustrates the application of oxygen gas barrier discharge plasma on dry cellulose fibre. The example fibre comes from paper pulp manufacture, but in principle is not limited to wood source. The action of the oxygen plasma is to etch the microcellulose fibre structure, simultaneously oxidising the glue-functioning hemicellulose, rendering it potentially soluble, so that the nanopolymer crystalline-based cellulose fibrils can subsequently be readily delaminated from the initial microfiber, either under mild mechanical shearing forces or at the point of application using ultrasonication in aqueous medium, to form the commonly used nanocellulose gel-suspension, but newly at desired higher solids content. The absence of liquid water during this pretreatment process for CNF production can deliver significant reduction in cost and environmental load. In addition, transport of plasma treated dry product to the point of its transformation to nanocellulose gel can decrease fuel consumption drastically and so bring yet further environmental benefits.
Determination of optimal parameters for GPS/GNSS cycle slip detection algorithm
Authors: Ogaja Clement , Bilich Andria , Bennett Richard A. 
Published: February 2024

Abstract
Accurate detection of cycle slips is vital for geodetic GNSS-based positioning with carrier phase data, and for quality control of GNSS data processing for various applications. Typically, cycle slip detection algorithms use certain parameters, such as a scale factor of the root-mean-square (RMS) of residuals of linear combinations and an ionospheric threshold value, to flag potential cycle slips. The performance of an algorithm will depend on the values assigned for such parameters. It is important that the parameter values are optimized such that the algorithm minimizes the rates of both missed slips and false detections. We evaluate two parameters (a scale factor, k, of Hatch-Melbourne-Wübbena and ionosphere-free residual RMS and an ionospheric residual threshold, h) to determine their optimal value for cycle slip detection. We show that in the worst-case scenario involving only small slips of magnitudes ranging from 1 to 3 cycles, there is an optimal range of values which resulted in 93 to 97% success rate without any false detections. For the data quality considered in this study, we recommend an RMS scale factor of k= 6 and an ionospheric residual threshold of h = 0.3 as the optimal values for the cycle slip detection with at least 97% success rate. In the absence of formal confidence limits, we note that combinations of values in the range of 6 ≤ k ≤ 8 and 0.3 ≤ h ≤ 1.0 resulted in at least 90% success rate with zero false detections, which gives some indication of the sensitivity of the algorithm’s performance to the specific choice of the parameter values.
Assessment of longitudinal changes in immune responses in critically ill adults with COVID-19
Authors: Rynne Jennifer , Fish Matthew , Jennings Aislinn , Smith Peter , Mosavie Mia , Lam Carolyn , Kelly Sarah , Sanderson Barnaby , Arbane Gill , Lucchese Gianluca , Bosco Paolo , Camporota Luigi , Ostermann Marlies , Shankar-Hari Manu 
Published: February 2024

Abstract
Clinically, COVID-19 is often a mild or asymptomatic illness. However, in a subset of patients, a more severe illness with one or more organ dysfunction requiring intensive care (ICU) admission occurs (stated as critical COVID-19). Most studies assessing the immune responses in COVID-19 focus on patients with non-critical COVID-19, often assessing single biological domain (such as cytokines, leukocytes, proteomics, or transcriptomics) at single time point in patient’s illness. In this context, our cohort study of patients with critical COVID-19 with demographically similar pre-pandemic controls, characterised the longitudinal changes in multiple biological domains (28 plasma cytokines, 30 immune cell subsets identified using mass cytometry and pan-leukocyte transcriptome) at four clinically relevant timepoints between ICU admission and discharge. When compared with controls, on ICU admission day, patients with critical COVID-19, had altered cytokine/chemokine profile (high interleukin-6 (IL-6), IL-10, IL-13, CXCL10, with low CCL17, and CXCL5)), raised histones (H3.1, H3R8), robust plasmablast response despite lymphopenia, with enrichment of immunoglobulin production and interferon pathways in the transcriptome. Analyses of longitudinal transcriptome data highlights three immunologically distinct clusters that were discordant to clinical time points, indicating that the clinical time points do capture immune response trajectory. Complete integration of this multi-domain longitudinal data indicated that ~ 70% of immunological heterogeneity is explained by the transcriptome.
Larger Contribution of Anthropogenic Climate Change to the Increasing Frequency of Compound Droughts and Heatwaves in Poor Countries Compared to Wealthy Ones
Authors: Wang Shuo , Zhang Boen , Slater Louise 
Published: February 2024

Abstract
Compound drought-heatwave events (CDHWs) have attracted widespread attention due to their devastating effects on human societies and ecosystems, but little research has investigated inequalities in exposure to CDHWs under climate change. Here, we reveal a significant connection between CDHWs and poverty on a global scale using observations, global climate models, and climate change attribution. We find that low-income regions, located mainly in central Africa, experienced an increase of 377% [351%~403%] in the frequency of CDHWs from 1981 to 2020, twice as fast as high-income regions in other parts of the globe (184% [153%~204%]). In the absence of climate change, the frequency of CDHWs would not have increased in low-income regions but would still have increased in high-income regions. Climate change has doubled the frequency of CDHWs over 31% [14%~50%] of low-income regions, yet only over 4.7% [0.9%~8.3%] of high-income regions. We also show that anthropogenic climate change has made a greater contribution to increases in the frequency of CDHWs in poorer countries than in wealthier countries. These findings highlight the need to prioritize climate policies to mitigate social inequalities exacerbated by anthropogenic influences and to achieve sustainable development goals.
Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR
Authors: Simpkins Fiona , Xu Haineng , Geroge Erin , Gallo David , Medvedev Sergey , Wang Xiaolei , Kryczka Rosie , Hyer Marc , Fourtounis Jimmy , Stocco Rino , Aguado-Fraile Elia , Petrone Adam , Yin Shou Yun , Shiwram Ariya , Anderson Matthew , Kim Hyoung , Liu Fang , Marshall Gary 
Published: February 2024

Abstract
Ovarian cancers (OVCAs) and endometrial cancers (EMCAs) with CCNE1-amplification are often resistant to standard of care treatment and represent an unmet clinical need. Previously, synthetic-lethal screening identified loss of the CDK1 regulator, PKMYT1, as synthetically lethal with CCNE1-amplification. We hypothesized that CCNE1-amplification associated replication stress will be more effectively targeted by combining the PKMYT1 inhibitor, lunresertib (RP-6306), with the ATR inhibitor, camonsertib (RP-3500/RG6526). Low dose combination RP-6306 with RP-3500 synergistically increased cytotoxicity more in CCNE1 amplified compared to non-amplified cells. Combination treatment produced durable antitumor activity and increased survival in CCNE1 amplified patient-derived and cell line-derived xenografts. Mechanistically, low doses of RP-6306 with RP-3500 increase CDK1 activation more so than monotherapy, triggering rapid and robust induction of premature mitosis, DNA damage and apoptosis in a CCNE1-dependent manner. These findings suggest that targeting CDK1 activity by combining RP-6306 with RP-3500 is a novel therapeutic approach to treat CCNE1-amplifed OVCAs and EMCAs.
Low-cost pyrolysis of biomass-derived nitrogen-doped porous carbon: chlorella vulgaris replaces melamine as a nitrogen source
Authors: LU Changxing , Yang Jing , Yu Zhaosheng , Zhang Xikui , Ma xiaoqian 
Published: February 2024

Abstract
Porous carbon generated from biomass has a rich pore structure, is inexpensive, and has a lot of promise for use as a carbon material for energy storage devices. In this work, nitrogen-doped porous carbon was prepared by co-pyrolysis using bagasse as the precursor and chlorella as the nitrogen source. The thermal weight loss experiments showed that the pyrolysis temperatures of bagasse and chlorella overlap, which created the possibility for the synthesis of nitrogen-rich biochar. The optimum sample (ZBC@C-5) possessed a surface area of 1508 m2g-1 with abundant nitrogen-containing functional groups. ZBC@C-5 in the three-electrode system exhibited 244.1F/g at 0.5A/g, which was extremely close to ZBC@M made with melamine as the nitrogen source. This provides new opportunities for the use of low-cost nitrogen sources. Furthermore, the devices exhibit better voltage retention (39%) and capacitance retention (96.3%). The goal of this research is to find a low cost, and effective method for creating nitrogen-doped porous carbon materials with better electrochemical performance for highly valuable applications using bagasse and chlorella.
Ex Vivo Noninvasive Electrophysiologic Imaging Based on Cardiac Electrophysiology Simulation and Clinical Data
Authors: Chang Yi , Dong Ming , Fan Lihong , Sun Weikai , Li Xiaofeng , Yang Zhang , Kang Bochao , Ren Ming 
Published: February 2024

Abstract
Background: The risk stratification and prognosis of cardiac arrhythmia depend on the individual condition of patients, while invasive diagnostic methods may be risky to patient health, and current non-invasive diagnostic methods are applicable to few disease types without sensitivity and specificity. Cardiac electrophysiologic imaging technology reflects cardiac activities accurately and non-invasively, which is of great significance for the diagnosis and treatment of cardiac diseases.
Methods: A complete three-dimensional bidomain cardiac electrophysiologic activity model was constructed, and simulated electrocardiogram data were obtained as training samples. Particle swarm optimization-back propagation neural network, convolutional neural network, and long short-term memory network were used respectively to reconstruct the cardiac surface potential.
Results: The conduction sequence of simulation model is basically consistent with that of human heart. The P waves, PR intervals, QRS complex, and T waves in the simulated waveforms were within the normal clinical range, and the distribution trend of the simulated body surface potential mapping was consistent with the clinical data. The coefficient of determination R2 between the reconstruction results of all the algorithms and the true value is above 0.73, and the mean absolute error is below 14 mV, among which the R2 of long short-term memory network is about 0.97 and the mean absolute error about 1.2 mV.
Conclusions: The electrophysiologic model constructed in this study can reflect the cardiac electrical activity, and basically contains the mapping relationship between the cardiac potential and the body surface potential. In cardiac potential reconstruction, long short-term memory network has significant advantages over other algorithms.
High-Intensity Interval Training improves bone remodeling, lipid profile, and physical function in multiple sclerosis patients
Authors: Amato Alessandra , Proia Patrizia , Alioto Anna , Rossi Carlo , Pagliaro Andrea , Ragonese Paolo , Schirò Giuseppe , Salemi Giuseppe , Caldarella Rosalia , Vasto Sonya , Nowak Robert , Kostrzewa-Nowak Dorota , Baldassano Sara 
Published: February 2024

Abstract
Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease due to an autoimmune chronic inflammatory response and the etiology is currently not completely understood. Is already known that physical activity plays an essential role in improving quality of life, especially in neuropathological conditions. The study aimed to investigate the possible benefits of high-intensity interval training (HIIT) in bone and lipid metabolism markers, and neuromotor abilities in MS patients. 130 participants were recruited; 16 subjects with MS met the inclusion criteria and were included in the data analysis. The patients were randomly assigned to two groups: a control group (CG) (34,88 ± 4,45 yrs) that didn’t perform any physical activity and the Exercise group (EG) (36,20 ± 7,80 yrs) that performed HIIT protocol. The training program was conducted remotely by clinical kinesiology. It was performed three times a week for 8 weeks. At the beginning (T0) and the end of the study (T1) were performed Bioimpedance analysis, coordination skills tests, and bone and lipid markers analysis. After 8 weeks of training the wall squat (s) (T0= 27.18±4.21; T1= 41.68±5.38, p ≤0.01) and Time Up and Go test (s) (T0= 7.65±0.43; T1= 6.34±0.38 p ≤0.01) performances improved; lipid markers analysis showed a decrease in Total (mg/dl) (T0= 187.22±15.73; T1= 173.44±13.03, p≤0.05) and LDL (mg/dl) (T0=108±21.08; T1= 95.02±17.99, p<0.05) cholesterol levels. Additionally, the levels of osteocalcin (µg/L), a marker of bone formation increased (T0= 20.88±4.22; T1=23.66±6.24, p<0.05) 25-OH Vitamin D (µg/L) improved after 8 weeks (T0=21.11±7.11; T1=27.66±7.59, p<0.05). High-intensity interval training had an effect on lower limb strength and gait control, improved bone formation, and lipid management, in multiple sclerosis patients.
WITHDRAWN: Coronavirus Disease 2019 and its Impact on the Cognition of Older Adults: Unraveling the Role of Inflammation
Authors: Mortazavi Shahrzad , Rashedi Vahid , Cheraghian Bahman , Pourshams Fatemeh , Saeidimehr Saeid , Dehghan Bahram , Pourshams Maryam 
Published: February 2024

Abstract

The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
Barriers and perceptions regarding research among Ophthalmology residents in Thailand
Authors: Mukdar Yanee , Sermsripong Wasawat , Sanpan Wilawan , Sawangkul Supattra , Choopong Pitipol 
Published: February 2024

Abstract

To assess barriers and perceptions of research among ophthalmology residents, discerning differences based on prior research experience before commencing ophthalmology training. Data were collected through an online survey using Google Forms, with participants utilizing a 5-point Likert scale for agreement. The survey achieved a 51.3% response rate from 122 ophthalmology residents, with 54.1% reporting prior research experience before residency. The top three obstacles identified were “lack of statistical knowledge” (mean 3.80, standard deviation 1.18), “lack of knowledge and experience in manuscript writing” (mean 3.79, SD 1.21), and “lack of time due to routine workload” (mean 3.75, SD 1.15). Residents without research experience demonstrated greater difficulties in research skills, manuscript preparation, and motivation for research submission. While research attitudes were positive (mean 3.20, SD 1.18), residents with prior experience displayed more favorable attitudes in various aspects of research, including preferences, perceived educational and career advantages, potential for income generation, and enhancement of communication skills. Conversely, the non-experienced residents primarily viewed research as a graduation requirement. In summary, ophthalmology residents encounter challenges in research due to limited statistical knowledge and inadequate manuscript writing competency. Implementing targeted support measures can foster positive attitudes and sustain engagement among residents.