bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of earthquake resilience factors for buildings: the case of Istanbul high-rise buildings
Authors: İlerisoy Zeynep Yeşim , Gökgöz Berru İzel 
Published: January 2024

PurposeThe objective of this study is to investigate the concept of “earthquake resistance” in high-rise buildings and assess the current level of structural strength in the areas where these structures are situated. The study aims to identify and implement necessary measures to enhance resilience in these areas. A comprehensive literature review was conducted to develop a conceptual framework focusing on earthquake resistance's meanings, stages and physical elements to achieve these goals.Design/methodology/approachThis study focuses on Istanbul, a city known for its high earthquake risk, specifically targeting the Atasehir district. The research utilizes the DEMATEL (Decision-Making Trial and Evaluation Laboratory) method to evaluate urban resilience parameters. Additionally, the Fuzzy TOPSIS (Preference Ranking Technique by Similarity) method is employed to analyze the location of five buildings in Atasehir, using criterion weights derived from this methodology.FindingsThe findings indicate that resilience varies depending on the distance of the buffers. Moreover, the amount and quality of urban equipment in the study areas have a significant impact on the earthquake resistance level of the surrounding areas where high-rise buildings are situated. Building upon this analysis, the study suggests the implementation of measures aimed at augmenting the quantity and quality of urban facilities in the study areas, consequently enhancing urban resilience.Originality/valueThe originality and value of this study lie in its examination of seismic resilience within the context of high-rise buildings and the identification of necessary measures to increase resilience in areas where these structures are prevalent. By focusing on Istanbul, a city with a high earthquake risk, and specifically selecting the Atasehir district as the study area, this research provides a comprehensive conceptual framework for understanding urban resilience and its physical components. Moreover, the study offers a fresh perspective on urban resilience by highlighting the influence of tall buildings on the surrounding areas. Ultimately, it provides practical recommendations for architects, urban planners and other stakeholders to improve regional earthquake resilience.
Correlation between the part quality, strength and surface roughness of material extrusion process
Authors: Rafique Abdul Samad , Munir Adnan , Ghazali Numan , Ahsan Muhammad Naveed , Khurram Aqeel Ahsan 
Published: January 2024

Purpose
The purpose of this study was to develop a correlation between the properties of acrylonitrile butadiene styrene parts 3D printed by material extrusion (MEX) process.

Design/methodology/approach
The two MEX parameters and their values have been selected by design of experiment method. Three properties of MEX parts, i.e. strength (tensile and three-point bending), surface roughness and the dimensional accuracy, are studied at different build speeds (35 mm/s, 45 mm/s and 55 mm/s) and the layer heights (0.06 mm, 0.10 mm and 0.15 mm).

Findings
The results show that tensile strength and three-point bending strength both increase with the decrease in build speed and the layer height. The artifact selected for dimensional accuracy test shows higher accuracy of the features when 3D printed with 0.06 mm layer height at 35 mm/s build speed as compared to those of higher layer heights and build speeds. The optical images of the 3D-printed specimen reveal that lower build speed and the layer height promote higher inter-layer diffusion that has the effect of strong bonding between the layers and, as a result, higher strength of the specimen. The surface roughness values also have direct relation with the build speed and the layer height.

Originality/value
The whole experiments demonstrate that the part quality, surface roughness and the mechanical strength are correlated and depend on the build speed and the layer height.
Probing frugal innovation from the quality lens
Authors: Sharma Mohita Gangwar , Kumar Sunil 
Published: January 2024

PurposeFrugal innovation focuses on the core functionalities with the highest stakeholder benefits and directly targets user requirements. It has been widely adopted in developing countries, and extensively researched from both consumer and sustainable perspectives. However, few studies on frugal innovation consider “quality”, a seminal business management concept. This study focuses on this gap and uses a quality lens to understand frugal innovation.Design/methodology/approachThis study adopts a mixed methodology. The Delphi focus group method is first applied to identify two cases of frugal innovation in the construction industry and a cross-case analysis done. Then, the analytic hierarchy process (AHP) is used to examine eight product quality dimensions to draw the final conclusions.FindingsFrom Garvin’s concept of quality, frugal innovation focuses on performance and conformance. Furthermore, it prioritises a value-based approach the most.Research limitations/implicationsThis study examines frugal innovation from quality perspective. This opens up a new line of research which contributes to both streams. The study is based on construction which is a limitation of the study.Practical implicationsA quality-based frugal innovation understanding can be helpful in the conceptualisation, implementation and acceptance of the frugal innovation business model. It can provide clarity on the innovation's value proposition and also help in operationalisation of the business model.Social implicationsFrugal encourages social entrepreneurs and understanding of the concept from quality perspective shall facilitate the operationalisation will become easier for them.Originality/valueTo the author’s knowledge, this is the first study at the interface of frugal innovation and quality management. Furthermore, the use of AHP to prioritise equality approaches and dimensions is an original contribution.
Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial
Authors: An Guanghui , Qiu Yan , Zhou Zheliang , Ding Xueying , Li Cheng 
Published: January 2024

AbstractThe pharmacodynamics in patients with high body fat percentage might be similar to those in obese patients. This randomised controlled clinical trial observed the effects of rocuronium in patients with different percent body fats (PBFs). Fifty‐four patients who underwent elective urological or pelvic surgery under general anaesthesia at Shanghai General Hospital were included in the present study; 51 patients were included for data analysis. Patients with normal PBF (<25%) were given a single dose of rocuronium calculated based on total body weight (N‐TBW, control group). Patients with a higher PBF (≥25%) were given a single dose of rocuronium calculated based on total body weight (H‐TBW). Patients with higher PBF and rocuronium were dosed based on fat‐free mass (H‐FFM). A train of four (TOF)‐Watch acceleromyography monitor was used to measure the effects of the rocuronium. H‐TBW (91.9 ± 28.8 s) had significantly shorter onset time than N‐TBW and H‐FFM (p = 0.003). H‐TBW had significantly longer clinical duration time and pharmacological duration time than the other groups (p = 0.000 and 0.000, respectively); the TOF ratio0.25–0.9 time was significantly different among the three groups (p = 0.005). There were no significant differences in the recovery time (p = 0.103) or recovery index (p = 0.159) among the three groups. The effects of rocuronium dosed based on FFM in patients with high PBFs are similar to those in normal patients. A single dose of rocuronium calculated based on TBW might shorten the onset time, prolong the clinical and pharmacological duration times, and prolong the recovery time.
Persistence of heterologous Flavobacterium psychrophilum genetic variants in microcosms simulating fish farm and hatchery environments
Authors: Knupp Christopher , Soto Esteban , Call Douglas R. , Loch Thomas P. 
Published: January 2024

AbstractFlavobacterium psychrophilum, the causative agent of bacterial coldwater disease, causes substantial economic losses in salmonid farms and hatcheries. Some multilocus sequence types (ST) of F. psychrophilum are more likely to be associated with fish farms and hatcheries, but it is unclear if these patterns of association represent genetic lineages that are more adapted to aquaculture environments. Towards elucidating the disease ecology of F. psychrophilum, the culturability of 10 distinct F. psychrophilum STs was evaluated for 13 weeks in three microcosms including sterilized well water, sterilized well water with commercial trout feed, or sterilized well water with raceway detritus. All STs remained culturable in each of the microcosms for at least 8 weeks, with bacterial concentrations often highest in the presence of raceway detritus. In addition, most (e.g., 90%) STs remained culturable for at least 13‐weeks. Significant differences in log10 cfus were observed among STs, both within and between microcosms, suggesting potential variability in environmental persistence capacity among specific variants. Collectively, results highlight the ability of F. psychrophilum to not only persist for weeks under nutrient‐limited conditions but also thrive in the presence of organic substrates common in fish farms and hatchery‐rearing units.
Masks and Faces in the Setting at the Time of Coronavirus
Authors: Presciuttini Silvia 
Published: January 2024

AbstractThe “health emergency” forced analysts to seek new ways of continuing with analysis. The article focuses, in particular, on the changes brought about in the setting by the presence of the sanitary mask, following a line that begins with the theme of the “mask” in the collective uses of human cultures, and develops through the Jungian concept of persona, as opposed to the “face” that may convey an authentic image of oneself. A clinical vignette illustrates the issues that the mask raises in the setting by obstructing the communication of emotions. When there is no transformative processing of concrete data, “unmasking” can also lead to an uncanny encounter and to moments of darkness and confusion in analysis, when the analyst experiences the kind of “unconscious identity” between therapist and patient that Jung defined as nigredo. The article is intended as a contribution to the analytic community's current reflections on the new and unforeseen challenges encountered in analysis at the time of the Coronavirus. It is possible to learn from these experiences with a view to integrating new elements and thus modify one's own internal setting, the compass with which each analyst orientates himself.
GeneMiner: A tool for extracting phylogenetic markers from next‐generation sequencing data
Authors: Xie Pulin , Guo Yongling , Teng Yue , Zhou Wenbin , Yu Yan 
Published: January 2024

AbstractThe advancement of next‐generation sequencing (NGS) technologies has been revolutionary for the field of evolutionary biology. This technology has led to an abundance of available genomes and transcriptomes for researchers to mine. Specifically, researchers can mine for various types of molecular markers that are vital for phylogenetic, evolutionary and ecological studies. Numerous tools have been developed to extract these molecular markers from NGS data. However, due to an insufficient number of well‐annotated reference genomes for non‐model organisms, it remains challenging to obtain these markers accurately and efficiently. Here, we present GeneMiner, an improved and expanded version of our previous tool, Easy353. GeneMiner combines the reference‐guided de Bruijn graph assembly with seed self‐discovery and greedy extension. Additionally, it includes a verification step using a parameter‐bootstrap method to reduce the pitfalls associated with using a relatively distant reference. Our results, using both experimental and simulation data, showed GeneMiner can accurately acquire phylogenetic molecular markers for plants using transcriptomic, genomic and other NGS data. GeneMiner is designed to be user‐friendly, fast and memory‐efficient. Further, it is compatible with Linux, Windows and macOS. All source codes are publicly available on GitHub (https://github.com/sculab/GeneMiner) and Gitee (https://gitee.com/sculab/GeneMiner) for easy accessibility and transparency.
Rapid and synchronous chemical induction of replicative‐like senescence via a small molecule inhibitor
Authors: Palikyras Spiros , Sofiadis Konstantinos , Stavropoulou Athanasia , Danieli‐Mackay Adi , Varamogianni‐Mamatsi Vassiliki , Hörl David , Nasiscionyte Simona , Zhu Yajie , Papadionysiou Ioanna , Papadakis Antonis , Josipovic Natasa , Zirkel Anne , O'Connell Aoife , Loughran Gary , Keane James , Michel Audrey , Wagner Wolfgang , Beyer Andreas , Harz Hartmann , Leonhardt Heinrich , Lukinavicius Grazvydas , Nikolaou Christoforos , Papantonis Argyris 
Published: January 2024

AbstractCellular senescence is acknowledged as a key contributor to organismal ageing and late‐life disease. Though popular, the study of senescence in vitro can be complicated by the prolonged and asynchronous timing of cells committing to it and by its paracrine effects. To address these issues, we repurposed a small molecule inhibitor, inflachromene (ICM), to induce senescence to human primary cells. Within 6 days of treatment with ICM, senescence hallmarks, including the nuclear eviction of HMGB1 and ‐B2, are uniformly induced across IMR90 cell populations. By generating and comparing various high throughput datasets from ICM‐induced and replicative senescence, we uncovered a high similarity of the two states. Notably though, ICM suppresses the pro‐inflammatory secretome associated with senescence, thus alleviating most paracrine effects. In summary, ICM rapidly and synchronously induces a senescent‐like phenotype thereby allowing the study of its core regulatory program without confounding heterogeneity.
The antioxidant N‐acetyl cysteine inhibits cytokine and prostaglandin release in human fetal membranes stimulated ex vivo with lipoteichoic acid or live group B streptococcus
Authors: Park Hae‐Ryung , Harris Sean M. , Boldenow Erica , Aronoff David M. , Rea Meaghan , Xi Chuanwu , Loch‐Caruso Rita 
Published: January 2024

AbstractBackgroundsInfection during pregnancy is a significant public health concern due to the increased risk of adverse birth outcomes. Group B Streptococcus or Streptococcus agalactiae (GBS) stands out as a major bacterial cause of neonatal morbidity and mortality. We aimed to explore the involvement of reactive oxygen species (ROS) and oxidative stress pathways in pro‐inflammatory responses within human fetal membrane tissue, the target tissue of acute bacterial chorioamnionitis.MethodsWe reanalyzed transcriptomic data from fetal membrane explants inoculated with GBS to assess the impact of GBS on oxidative stress and ROS genes/pathways. We conducted pathway enrichment analysis of transcriptomic data using the Database for Annotation, Visualization and Integrated Discovery (DAVID), a web‐based functional annotation/pathway enrichment tool. Subsequently, we conducted ex vivo experiments to test the hypothesis that antioxidant treatment could inhibit pathogen‐stimulated inflammatory responses in fetal membranes.ResultsUsing DAVID analysis, we found significant enrichment of pathways related to oxidative stress or ROS in GBS‐inoculated human fetal membranes, for example, “Response to Oxidative Stress” (FDR = 0.02) and “Positive Regulation of Reactive Oxygen Species Metabolic Process” (FDR = 2.6*10−4). There were 31 significantly changed genes associated with these pathways, most of which were upregulated after GBS inoculation. In ex vivo experiments with choriodecidual membrane explants, our study showed that co‐treatment with N‐acetylcysteine (NAC) effectively suppressed the release of pro‐inflammatory cytokines (IL‐6, IL‐8, TNF‐α) and prostaglandin PGE2, compared to GBS‐treated explants (p < .05 compared to GBS‐treated samples without NAC co‐treatment). Furthermore, NAC treatment inhibited the release of cytokines and PGE2 stimulated by lipoteichoic acid (LTA) and lipopolysaccharide (LPS) in whole membrane explants (p < .05 compared to LTA or LPS‐treated samples without NAC co‐treatment).ConclusionsOur study sheds light on the potential roles of ROS in governing the innate immune response to GBS infection, offering insights for developing strategies to mitigate GBS‐related adverse outcomes.
Running on Empty: Depletion and Social Reproduction in Myanmar and Sri Lanka
Authors: Lingham Jayanthi Thiyaga , Johnston Melissa 
Published: January 2024

AbstractA social reproduction framework that uses depletion reveals how multiple crises intersect. We deploy this framework to examine the relationship between depletion and conflict. Drawing on research undertaken in Myanmar and Sri Lanka in early 2020, we argue that the weight of social reproduction under conflict conditions increases women's depletion. Our findings showed, however, that increased depletion was not due primarily to increased social reproductive labour but because of the intervening effects of conflict and violence against women. These findings add utility to the concept of depletion. We argue that understanding the depth of depletion in conflict requires more than a mathematical calculation. We also contend that depletion of social reproductive resources is a tactic of conflict. Therefore, to understand depletion through social reproduction in conflict, we must expand the concept to include the depletion of social reproduction. Lastly, we show that violence against women is a significant factor in women's depletion.
Editorial: Can we predict or not predict response to hypnotherapy? That is the question. Authors' reply
Authors: Vasant Dipesh H. , Whorwell Peter J. 
Published: January 2024

LINKED CONTENTThis article is linked to Devenney et al papers. To view these articles, visit https://doi.org/10.1111/apt.17790 and https://doi.org/10.1111/apt.17812
Editorial: How does the risk of hepatocellular carcinoma change over time in patients with a hepatitis C cure? Authors' reply
Authors: Vutien Philip , Kim Nicole J. , Moon Andrew M. , Johnson Kay M. , Berry Kristin , Green Pamela K. , Ioannou George N. 
Published: January 2024

LINKED CONTENTThis article is linked to Vutien et al papers. To view these articles, visit https://doi.org/10.1111/apt.17802 and https://doi.org/10.1111/apt.17818
Letter: Baseline age on antiviral treatment may significantly influence the clinical response of children with chronic hepatitis B ‐ authors' reply
Authors: OuYang WenXian , Li ShuangJie , Peng Songxu 
Published: January 2024

LINKED CONTENTThis article is linked to Wu et al papers. To view these articles, visit https://doi.org/10.1111/apt.17667 and https://doi.org/10.1111/apt.17830
Duterte's transactionalist foreign policy and the COVID‐19 crisis in the Philippines
Authors: Candelaria John Lee , Talamayan Fernan 
Published: January 2024

AbstractThis article contributes a new layer to the existing analyses of Duterte's foreign policy by arguing that he epitomized a transactionalist approach to Philippine foreign policy. This approach favored bilateral to multilateral relations, focused on short‐term wins rather than long‐term foresight, adhered to a zero‐sum worldview, rejected value‐based policymaking, and did not follow a grand strategy. Most of these qualities have been apparent in Duterte's relationship with China, Russia, and the United States but became even more prominent during the COVID‐19 crisis. The analysis revealed that Duterte's transactionalist foreign policy rhymed with his domestic politics, and his obsession with winning now resulted in contradictions in his foreign policy, indicating a lack of a grand strategy that informed his decision‐making. This article contributes a real‐world case of a transactionalist foreign policy while considering whether it would persist in future policymaking in the Philippines.
miRNA levels are associated with body mass index in endometrial cancer and may have implications for therapy
Authors: Ravegnini Gloria , Gorini Francesca , Coada Camelia Alexandra , De Leo Antonio , de Biase Dario , Di Costanzo Stella , De Crescenzo Eugenia , Coschina Emma , Monesmith Sarah , Bernante Paolo , Garelli Silvia , Balsamo Francesca , Hrelia Patrizia , De Iaco Pierandrea , Angelini Sabrina , Perrone Anna Myriam 
Published: January 2024

AbstractEndometrial cancer (EC) is the most prevalent gynecological cancer in high‐income countries. Its incidence is skyrocketing due to the increase in risk factors such as obesity, which represents a true pandemic. This study aimed to evaluate microRNA (miRNA) expression in obesity‐related EC to identify potential associations between this specific cancer type and obesity. miRNA levels were analyzed in 84 EC patients stratified based on body mass index (BMI; ≥30 or <30) and nine noncancer women with obesity. The data were further tested in The Cancer Genome Atlas (TCGA) cohort, including 384 EC patients, 235 with BMI ≥30 and 149 with BMI <30. Prediction of miRNA targets and analysis of their expression were also performed to identify the potential epigenetic networks involved in obesity modulation. In the EC cohort, BMI ≥30 was significantly associated with 11 deregulated miRNAs. The topmost deregulated miRNAs were first analyzed in 84 EC samples by single miRNA assay and then tested in the TCGA dataset. This independent validation provided further confirmation about the significant difference of three miRNAs (miR‐199a‐5p, miR‐449a, miR‐449b‐5p) in normal‐weight EC patients versus EC patients with obesity, resulting significantly higher expressed in the latter. Moreover, the three miRNAs were significantly correlated with grade, histological type, and overall survival. Analysis of their target genes revealed that these miRNAs may regulate obesity‐related pathways. In conclusion, we identified specific miRNAs associated with BMI that are potentially involved in modulating obesity‐related pathways and that may provide novel implications for the clinical management of obese EC patients.
Introgression and incomplete lineage sorting blurred phylogenetic relationships across the genomes of sclerophyllous oaks from southwest China
Authors: Ma Xiang‐Guang , Ren Yue‐Bo , Sun Hang 
Published: January 2024

AbstractResolving evolutionary relationships among closely related species with interspecific gene flow is challenging. Genome‐scale data provide opportunities to clarify complex evolutionary relationships in closely related species and to observe variations in species relationships across the genomes of such species. The Himalayan–Hengduan subalpine oaks have a nearly completely sympatric distribution in southwest China and probably constitute a syngameon. In this study, we mapped resequencing data from different species in this group to the Quercus aquifolioides reference genome to obtain a high‐quality filtered single nucleotide polymorphism (SNP) dataset. We also assembled their plastomes. We reconstructed their phylogenetic relationships, explored the level and pattern of introgression among these species and investigated gene tree variation in the genomes of these species using sliding windows. The same or closely related plastomes were found to be shared extensively among different species within a specific geographical area. Phylogenomic analyses of genome‐wide SNP data found that most oaks in the Himalayan–Hengduan subalpine clade showed genetic coherence, but several species were found to be connected by introgression. The gene trees obtained using sliding windows showed that the phylogenetic relationships in the genomes of oaks are highly heterogeneous and therefore highly obscured. Our study found that all the oaks of the Himalayan–Hengduan subalpine clade from southwest China form a syngameon. The obscured phylogenetic relationships observed empirically across the genome are best explained by interspecific gene flow in conjunction with incomplete lineage sorting.