bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents’ Views on Autopsy, Organ Donation, and Research Donation After Neonatal Death
Authors: Crouch Elizabeth E. , Damas Carlos , Bartrug William C. , Shamiyeh Anne , Scelfo Meghan , Dreyfus Madeleine , Gano Dawn , Segal Summer , Franck Linda S. 
Published: November 2023

ImportanceParents who experience neonatal loss have the option to participate in autopsy, organ donation, and research donation. However, clinicians are uncomfortable discussing autopsy and may not be aware of research and organ donation opportunities.ObjectiveTo capture the perspectives of parents who had experienced neonatal loss about autopsy, organ donation, and research donation.Design, Setting, and ParticipantsThis qualitative study used virtual focus groups with parents who attended a local bereavement support group in the US. Participants were recruited from Helping After Neonatal Death, a support group with a local chapter. Participants self-selected from an email request if they met the following criteria: aged 18 years or older, English speaking, at least 6 months elapsed since neonatal death, and access to a video conference device with internet. Focus groups took place between April and September 2021. The recorded sessions were analyzed using a grounded theory–informed approach by the research team that included parents with experience of neonatal loss. Data were analyzed from December 2021 through December 2022.ResultsA total of 14 mothers engaged in the focus group; 9 (75%) were aged 30 to 39 years, and 8 (66%) were White. The mothers were overall well educated. The first main theme grew from the lived experience of neonatal loss, specifically the importance of offering all parents the option to donate, rather than prejudging who would or would not be interested. Parents of neonates who die have few opportunities to parent that child and make loving decisions for them. Participants emphasized that the conversation about autopsy, organ donation, and research donation, albeit difficult, can offer a meaningful parenting experience. A second main theme that emerged related to how organ or tissue donation could provide additional meaning to a child’s life. These choices contributed to building a legacy to honor their child’s memory, which also helped with grief and coping with their loss. A third theme included recommendations to clinicians and health systems for improving communication, including written information for parents and communication training for health care professionals.Conclusions and RelevanceIn this qualitative study, parents who experienced neonatal loss endorsed the importance of offering parents the choice of autopsy, organ donation, or research donation with skillful and empathetic communication. They provided practical recommendations to improve communication and empower families.
Silver─Gallium Nano‐Amalgamated Particles as a Novel, Biocompatible Solution for Antibacterial Coatings
Authors: Nguyen Tien Thanh , Zhang Pengfei , Bi Jingwei , Nguyen Ngoc Huu , Dang Yen , Xu Zhaoning , Wang Hao , Ninan Neethu , Bright Richard , Pham Tuyet , Nguyen Chung Kim , Sabri Ylias , Nguyen Manh Tuong , Vongsvivut Jitraporn , Zhao Yunpeng , Vasilev Krasimir , Truong Vi Khanh 
Published: November 2023

AbstractBacterial infections account for countless deaths globally. Antibiotics are the primary countermeasure; however, the alarming spread of antibiotic‐resistant strains necessitates alternative solutions. Silver and silver compounds have emerged as promising antibacterial agents. However, issues related to cytotoxicity and genotoxicity of silver remain concern. To overcome these challenges, this proposes an easy‐to‐control and straightforward method to synthesize novel Silver─gallium (Ag─Ga) nano‐amalgamated particles. Gallium liquid metal (GaLM) is used to facilitate the galvanic deposition of silver nanocrystals (Ag) on oxide layer. The GaLM not only serves as a carrier for silver through the galvanic replacement process, but also provides a controlled‐release mechanism for silver, in this way improving biocompatibility, reducing inflammation, and stimulating bone growth. Notably, Ag─Ga suspensions can be conveniently deposited by spray‐coating on a range of devices and material surfaces, effectively eliminating pathogenic bacteria with efficacy comparable to that of silver ions. In vivo studies in rat models affirm the antibacterial capabilities, especially against methicillin‐resistant Staphylococcus aureus and Escherichia coli, when placed on implants such as titanium rods and magnesium discs. Furthermore, Ag─Ga promotes bone matrix formation and collagen growth without eliciting an inflammatory response, indicating a major promise for coatings on a wide variety of biomedical devices and materials.
Adaptive Gating Enhances Intelligent Membranes for Cellular Functions and Precise Separations
Authors: Zhang Mengchen , Xing Chao , Huang Jianan , Li Peishan , Jiang Long , Liu Lingfeng , Jia Jianbo , Zhang Xiwang , Zhang Shanqing , Liu Changyu 
Published: November 2023

AbstractIntelligent membranes with adaptive gating channels play a crucial role in cellular functions and separation processes. This study introduces a novel approach to controlling channel expansion using biomimetic adaptive aggregates, fundamentally overcoming the drawbacks of existing methods relying on intertwined polyelectrolyte chains for channel blockage. Specifically, a pH‐responsive 2D material membrane is constructed through the self‐assembling of protein‐mimetic zwitterionic polydopamine (ZPDA) soft molecular aggregates within graphene oxide (GO) interlayers. Similar to the conformational switch of inserted proteins in cellular membranes, the embedded ZPDA in GO nanofluidic channels undergoes an adaptive conformational transformation in response to pH changes. This dynamic adjustment of ZPDA physicochemical properties allows for reversible regulation of GO nanofluidic channel size and charge by external pH modulation. The resulting GO/ZPDA membrane exhibits programmable separation performance for dye molecules (i.e., water permeance of 18.8–35.4 L m−2 h−1 bar−1 and molecular selectivity of 73.7–32.9) and salt ions (i.e., ionic permeance of 0.69–1.25 mol m−2 h−1 and ionic selectivity of 20.8–21.9). This work sheds new light on the engineering of intelligent stimuli‐responsive 2D nanofluidic channels with adaptive gating properties, holding promise across a wide range of applications including separation, drug delivery, sensing, and catalysis.
Large‐Area Growth of Ferroelectric 2D γ‐In2Se3 Semiconductor by Spray Pyrolysis for Next‐Generation Memory
Authors: Lim Taebin , Lee Jae Heon , Kim Donggyu , Bae Jinbaek , Jung Seungchae , Yang Sang Mo , Jang Joon I. , Jang Jin 
Published: November 2023

AbstractIn2Se3, 2D ferroelectric‐semiconductor, is a promising candidate for next‐generation memory device because of its outstanding electrical properties. However, the large‐area manufacturing of In2Se3 is still a big challenge. In this work, spray pyrolysis technique is introduced for the growth of large‐area In2Se3 thin film. A polycrystalline γ‐In2Se3 layer can be grown on 15 cm × 15 cm glasss at the substrate temperature of 275 °C. The In2Se3 ferroelectric‐semiconductor field effect transistor (FeS‐FET) on glass substrate demonstrates a large hysteresis window of 40.3 V at the ±40 V of gate voltage sweep and excellent uniformity. The FeS‐FET exhibits an electron field effect mobility of 0.97 cm2 V−1 s−1 and an on/off current ratio of >107 in the transfer curves. The memory behavior of the large‐area, In2Se3 FeS‐FETs for next‐generation memory is demonstrated.
Intensity Dependent Photoluminescence Imaging for In‐Line Quality Control of Perovskite Thin Film Processing
Authors: Hacene Benjamin , Laufer Felix , Ternes Simon , Farag Ahmed , Pappenberger Ronja , Fassl Paul , Moghadamzadeh Somayeh , Nejand Bahram Abdollahi , Feeney Thomas , Howard Ian , Paetzold Ulrich W. 
Published: November 2023

AbstractLarge area fabrication of high‐quality polycrystalline perovskite thin films remains one of the key challenges for the commercial readiness of perovskite photovoltaic (PV). To enable high‐throughput and high‐yield processing, reliable and fast in‐line characterization methods are required. The present work reports on a non‐invasive characterization technique based on intensity‐dependent photoluminescence (PL) imaging. The change in PL intensity as a function of excitation power density can be approximated by a power‐law with exponent k, which is a useful quality indicator for the perovskite layer, providing information about the relative magnitudes of radiative and non‐radiative recombination. By evaluating k‐parameter maps instead of more established PL intensity images, 2D information is obtained that is robust to optically induced artifacts such as intensity variations in excitation and reflection. Application to various half stacks of a perovskite solar cell showcase its ability to determine the importance of the interface between the charge transporting and perovskite layers. In addition, the k‐parameter correlates to the bulk passivation concentration, enabling rapid assessment of open‐circuit voltage variations in the range of 20 mV. Considering expected improvements in data acquisition speed, the presented k‐imaging method will possibly be obtained in real‐time, providing large‐area quality control in industrial‐scale perovskite PV production.
Digital Light Processing 3D‐Printed Multilayer Dielectric Elastomer Actuator for Vibrotactile Device
Authors: Huang Peiwen , Fu Hongbo , Tan Matthew Wei Ming , Jiang Yixuan , Lee Pooi See 
Published: November 2023

AbstractDielectric elastomer actuators (DEAs) have emerged as promising components in the field of soft robotics. Multilayer DEAs can enhance the output performance compared to single‐layer DEAs, but the common layer‐by‐layer stacking methods are time‐consuming and likely susceptible to concerns about frequent dielectric breakdown. Herein, the one‐piece multilayer DEAs are directly fabricated via the digital light processing (DLP) 3D printing method, taking advantage of the precise and intricate printed structure. The study also focuses on the adjustable DLP printable resin formulation, aiming to achieve a DLP printed polyurethane acrylate (PUA)‐based dielectric elastomer (DE) material that exhibits desirable characteristics, such as an appropriate dielectric constant, modulus, and minimal hysteresis loss. The non‐pre‐stretch DLP‐printed cylindrical DEA demonstrates a significant blocked force of 270 mN and maintains 45% actuation performance at a frequency of 100 Hz, attributed to both the printed multilayer structure and the optimized formulation of the DE material. Moreover, the feasibility of DLP‐printed DEAs as vibrotactile devices is demonstrated. This work has advanced the development of rapid and efficient fabrication methods of multilayer DEAs using DLP printing, with enhanced force output and attractive applications in robotics and haptic interfaces.
A novel homozygous variant in ATL1 associated with early onset spastic paraplegia 3A: Further evidence for autosomal recessive inheritance
Authors: Darouich Sihem , Darouich Samia 
Published: November 2023

AbstractSpastic paraplegia 3A (SPG3A) has long been considered as an autosomal dominant disorder till the report in 2014 and 2016 of two consanguineous Arabic families, showing that ATL1 mutations may cause autosomal recessive paraplegia. Here, a third report of a consanguineous Arabic family with recessive SPG3A is described. Exome sequencing reveals homozygosity for a novel likely pathogenic ATL1 splice donor variant (c.522+1G>T) in an affected 5‐year‐old infant whereas the parents, heterozygous carriers, are asymptomatic. The infant's phenotype is consistent with an early onset complicated SPG3A with severe progressive spasticity of the lower limbs and intellectual disability.
Family adaptation in families of individuals with Down syndrome from 12 countries
Authors: Van Riper Marcia , Knafl George J. , Knafl Kathleen A. , do Céu Barbieri‐Figueiredo Maria , Barnoy Sivia , Caples Maria , Choi Hyunkyung , Cosgrove Beth , Duarte Elysângela Dittz , Honda Junko , Marta Elena , Phetrasuwan Supapak , Alfieri Sara , Angelo Margareth , Deoisres Wannee , Fleming Louise , dos Santos Aline Soares , da Silva Maria João Rocha 
Published: November 2023

AbstractOur current understanding of adaptation in families of individuals with Down syndrome (DS) is based primarily on findings from studies focused on participants from a single country. Guided by the Resiliency Model of Family Stress, Adjustment, and Adaptation, the purpose of this cross‐country investigation, which is part of a larger, mixed methods study, was twofold: (1) to compare family adaptation in 12 countries, and (2) to examine the relationships between family variables and family adaptation. The focus of this study is data collected in the 12 countries where at least 30 parents completed the survey. Descriptive statistics were generated, and mean family adaptation was modeled in terms of each predictor independently, controlling for an effect on covariates. A parsimonious composite model for mean family adaptation was adaptively generated. While there were cross‐country differences, standardized family adaptation mean scores fell within the average range for all 12 countries. Key components of the guiding framework (i.e., family demands, family appraisal, family resources, and family problem‐solving communication) were important predictors of family adaptation. More cross‐country studies, as well as longitudinal studies, are needed to fully understand how culture and social determinants of health influence family adaptation in families of individuals with DS.
Nitrene‐Mediated Enantioselective Intramolecular Olefin Oxyamination to Access Chiral γ‐Aminomethyl‐γ‐Lactones
Authors: Nie Xin , Ritter Clayton W. , Hemming Marcel , Ivlev Sergei I. , Xie Xiulan , Chen Shuming , Meggers Eric 
Published: November 2023

AbstractAttaching a nitrene precursor to an intramolecular nucleophile allows for a catalytic asymmetric intramolecular oxyamination of alkenes in which the nucleophile adds in an endocyclic position and the amine in an exocyclic fashion. Using chiral‐at‐ruthenium catalysts, chiral γ‐aminomethyl‐γ‐lactones containing a quaternary carbon in γ‐position are provided in high yields (up to 99 %) and with excellent enantioselectivities (up to 99 % ee). DFT calculations support the possibility of both a singlet (concerted oxyamination of the alkene) and triplet pathway (stepwise oxyamination) for the formation of the predominant stereoisomer. γ‐Aminomethyl‐γ‐lactones are versatile chiral building blocks and can be converted to other heterocycles such as δ‐lactams, 2‐oxazolidinones, and tetrahydrofurans.
Propofol‐induced myoclonus during maintenance of anaesthesia
Authors: Chao S. , Khan R. , Lieberman J. , Buren M. 
Published: November 2023

SummaryMyoclonus is a known side effect of propofol and can interfere with surgery and possibly precipitate patient injury. Here, we report a 23‐year‐old patient undergoing an L5 osteoblastoma resection with a predominantly propofol‐based anaesthetic who developed intra‐operative myoclonus. Other adjuncts included ketamine, lidocaine and fentanyl infusions. The myoclonus did not improve after deepening the anaesthetic with propofol, opioid boluses or discontinuation of the lidocaine infusion. The myoclonus ceased after reducing the propofol infusion and increasing the ketamine and opioid infusions. The remainder of the intra‐operative course was uneventful. This report details our intra‐operative management of propofol‐induced cortical reflex myoclonus and discusses our institution's experience with treating this phenomenon.
Knowledge, attitudes, and practices toward depression among physicians in Sudan
Authors: Mokhtar Ahmed Sohaib Mohammed , Mohamed Zain Elnazier Mohammed Ibrahim , Osman Osama Saeed 
Published: November 2023

AbstractObjectivesThe present study assessed the knowledge, attitudes, and practices of physicians in Sudan regarding depression.MethodsA cross‐sectional study was conducted among physicians who practiced at public and private health facilities in Sudan in December of 2022. An online Google form questionnaire was administered that included knowledge, practice, and sociodemographic sections of the depression attitude questionnaire. The link to the questionnaire was sent to a convenience sample of physicians through a variety of methods including social media.ResultsA total of 407 physicians completed the questionnaire. The majority (81.1%) had no formal training on mental health after graduation. A total of 43.0% reported difficulties in differentiating between unhappiness and clinical depression, although 48.6% indicated that they could differentiate between chemical and psychological causes for depression. Half (50.4%) did not feel comfortable dealing with depressed patients. Nearly 70% indicated that psychotherapy was a better option for treating these patients than antidepressants, but only 45.7% had any mental health services at their health facility. Physicians with prior mental health training (both pre‐ and postgraduate training) were more likely to provide treatment options for depressed patients.ConclusionsThis study indicates a moderate knowledge among physicians about depression, but also significant concern regarding poor attitudes and practices held toward the treatment of depression, and a lack of training. These findings highlight the urgent need for the training of physicians in the diagnosis and treatment of depression in Sudan.
Survival benefit and biomarker of PD‐1 inhibitor combination therapy in first‐line of advanced biliary tract cancer: A retrospective study
Authors: Guo Jingyi , Zhou Qun , Zhou Mingzhen , Dai Hengheng , Li Lin , Qiu Yudong , Mao Liang , Liu Baorui , Shen Jie 
Published: November 2023

AbstractBackgroundImmune checkpoint inhibitor (ICI) combination therapies have shown promise in the first‐line treatment of advanced biliary tract cancer (BTC). However, the best partner remains to be validated. Moreover, progress on biomarkers predicting the efficacy of ICI in BTC is slow. This study aimed to assess the efficacy and investigate reliable predictive biomarkers of programmed cell death protein‐1 (PD‐1) antibody combination therapy in the first‐line treatment of advanced BTC.MethodsClinical data from patients with advanced BTC who received chemotherapy or anti‐PD‐1 combination therapy as first‐line were collected. The primary outcome was overall survival (OS). Biomarkers, including peripheral blood inflammation scores, genetic alterations, and tumor microenvironment were investigated.FindingsSixty‐four patients were recruited and divided into four treatment groups: chemotherapy, anti‐PD‐1 plus chemotherapy, anti‐PD‐1 plus targeted therapy, and triple group (anti‐PD‐1 plus chemotherapy and targeted therapy). The median OS was 7.9, 11.3, 12.8, and 28.7 months, respectively. Compared to chemotherapy, mOS significantly prolonged in the triple group (p = 0.031). It showed that patients with five different peripheral blood inflammation scores had significantly prolonged mOS (p < 0.05). Genetic testing results suggested that patients with poor survival all had TP53 mutations and higher levels of KRAS and ERBB2 mutations. Low FOXP3/CD8 ratio was associated with prolonged OS (p = 0.029). With CD4‐low, CD8‐high, CD56‐positive, CD163‐high, FOXP3‐high and MPO‐high in TME as one factor, we calculated PLUS score according to the number of factors. The high‐PLUS (>2) group showed significantly superior OS (p = 0.003).InterpretationFirst‐line anti‐PD‐1 combination therapy was superior to chemotherapy, and triple therapy significantly improved survival. Peripheral blood immune‐inflammation score, FOXP3/CD8 ratio, and PLUS have potential as biomarkers for predicting the efficacy of first‐line anti‐PD‐1 therapy in advanced BTC.
Telehealth follow‐up consultations for melanoma patients during the COVID‐19 pandemic: Patient and clinician satisfaction
Authors: Al‐Rikaby Ali , Sulaiman Ahmad , Thompson Jake R. , Saw Robyn P. M. , Boyle Frances , Taylor Nicole , Carlino Matteo S. , Morton Rachael L. , Nieweg Omgo E. , Thompson John F. , Bartula Iris 
Published: November 2023

AbstractIntroductionThe COVID‐19 pandemic caused rapid implementation of telehealth for melanoma follow‐up care in Australia. This study explores Australian melanoma patients and clinicians' level of satisfaction with telehealth.MethodsA cross‐sectional study was conducted across three specialist melanoma centres in Sydney, Australia. Melanoma patients (all stages) and clinicians completed mixed methods surveys seeking socio‐demographic and clinical information and questionnaires to assess satisfaction with telehealth. Additionally, patients completed measures of quality of life, fear of cancer recurrence and trust in their oncologist. Patients and clinicians provided open‐ended responses to qualitative questions about their perceptions of telehealth.ResultsOne hundred and fifteen patients and 13 clinicians responded to surveys. Telephone was used by 109 (95%) patients and 11 (85%) clinicians. Fifty‐seven (50%) patients and nine (69%) clinicians preferred face‐to‐face consultations, 38 (33%) patients and 3 (23%) clinicians preferred a combination of face‐to‐face and telehealth consultations. Five (4%) patients and nil clinicians preferred telehealth consultations. Patients diagnosed with early‐stage melanoma, using telehealth for the first time, who have lower trust in their oncologist, and having higher care delivery, communication and supportive care concerns were likely to report lower satisfaction with telehealth. Open‐ended responses were consistent between patients and clinicians, who reported safety, convenience and improved access to care as major benefits, while identifying personal, interpersonal, clinical and system‐related disadvantages.DiscussionWhile telehealth has been widely implemented during COVID‐19, the benefits identified by patients and clinicians may extend past the pandemic. Telehealth may be considered for use in conjunction with face‐to‐face consultations to provide melanoma follow‐up care.
Quinones: Biosynthesis, Characterization of 13C Spectroscopical Data and Pharmacological Activities
Authors: Gomes de Carvalho Natália Kelly , Wellisson da Silva Mendes Johnatan , Martins da Costa José Galberto 
Published: November 2023

AbstractQuinones are natural products widely distributed in nature, which are involved in stages of several vital biological processes, with mostly having a variety of pharmacological properties. The main groups comprising most of these compounds are benzoquinones, naphthoquinones, anthraquinones, and phenanthraquinones. Quinone isolation has been a focus of study around the world in recent years; for this reason, this study approaches the junction of natural quinones identified by 13C Nuclear Magnetic Resonance (NMR) spectroscopic analytical techniques. The methodology used to obtain the data collected articles from various databases on quinones from 2000 to 2022. As a result, 137 compounds were selected, among which 70 were characterized for the first time in the period investigated; moreover, the study also discusses the biosynthetic pathways of quinones and the pharmacological activities of the compounds found, giving an overview of the various applications of these compounds.