bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway
Authors: Zhang Ge , Yu Tongyao , Chai Xiaoxia , Zhang Shilong , Liu Jie , Zhou Yan , Yin Dachuan , Zhang Chenyan 
Published: February 2024

Triple-negative breast cancer (TNBC) is the most aggressive and lethal malignancy in women, with a lack of effective targeted drugs and treatment techniques. Gradient rotating magnetic field (RMF) is a new technology used in oncology physiotherapy, showing promising clinical applications due to its satisfactory biosafety and the abundant mechanical force stimuli it provides. However, its antitumor effects and underlying molecular mechanisms are not yet clear. We designed two sets of gradient RMF devices for cell culture and animal handling. Gradient RMF exposure had a notable impact on the F-actin arrangement of MDA-MB-231, BT-549, and MDA-MB-468 cells, inhibiting cell migration and invasion. A potential cytoskeleton F-actin-associated gene, CCDC150, was found to be enriched in clinical TNBC tumors and cells. CCDC150 negatively correlated with the overall survival rate of TNBC patients. CCDC150 promoted TNBC migration and invasion via activation of the transforming growth factor β1 (TGF-β1)/SMAD3 signaling pathway in vitro and in vivo. CCDC150 was also identified as a magnetic field response gene, and it was marked down-regulated after gradient RMF exposure. CCDC150 silencing and gradient RMF exposure both suppressed TNBC tumor growth and liver metastasis. Therefore, gradient RMF exposure may be an effective TNBC treatment, and CCDC150 may emerge as a potential target for TNBC therapy.
COMPARISON OF ANGLE OPENING DISTANCE AND TRABECULAR IRIS SPACE AREA BEFORE AND AFTER LASER PERIPHERAL IRIDOTOMY IN ANGLE CLOSURE DISEASE
Authors: Ramdhani Rizki Fasa , Rifada R. Maula , Irfani Irawati , Gustianty Elsa , Umbara Sonie 
Published: February 2024

Introduction & ObjectivesLaser peripheral iridotomy (LPI) is the standard first-line therapy in angle closure disease toincrease anterior chamber angle width. Spectral Domain Anterior Segment Optical CoherenceTomography (SD AS-OCT) is an instrument that has a quantitative parameter to measure anteriorchamber angle. Angle opening distance (AOD) and trabecular iris space area (TISA) are quantitativeparameters in SD AS-OCT. The purpose of this study is to compare AOD and TISA before and oneweek after LPI in angle closure disease.
MethodsThis is an analytical prospective study with a cross-sectional study design. Twenty-two eyes withangle closure disease that met inclusion and exclusion criteria underwent LPI and SD AS-OCT beforeand one week after LPI. Analysis was performed using SD AS-OCT parameters, such as AOD(AOD500, AOD750) and TISA (TISA500, TISA750) in the temporal, nasal quadrants, and average.
ResultsTwenty-two eyes with angle closure are divided into nine eyes with primary angle closure suspect,seven eyes with primary angle closure, and six eyes with primary angle closure glaucoma. The meanage of participants was 57.86±7.63 years. There was a significant increase in AOD500, AOD750,TISA500, and TISA750 in the temporal and nasal quadrants, as well as in the average (P=0.0001)based on a paired t test or Wilcoxon as an alternative. Average AOD750 had the highest T-value (T=6.329) with a mean 0.20±0.096 before LPI and 0.31±0.144 one week after LPI.
ConclusionThere was a significant increase in AOD and TISA after one week LPI in angle closure disease.
Treatment of Vitreous Hemorrhage due to Proliferative Diabetic Retinopathy in Cipto Mangunkusumo Hospital During Pandemic Era (March 2020 - March 2022)
Authors: RAHAYU TSANIA RACHMAH , Andayani Gitalisa 
Published: February 2024

Introduction & ObjectivesProliferative diabetic retinopathy (PDR) is the most common etiology for vitreous hemorrhage (VH)and can be sight-threatening. Current treatment modalities for VH in PDR included anti-VEGFinjection, panretinal photocoagulation (PRP) laser, and vitrectomy. We conducted study to evaluatetreatment modalities and outcomes of VH in PDR during the pandemic era.
MethodsA retrospective study of VH in PDR was conducted at Cipto Mangunkusumo Hospital, Indonesia,from March 2020 to March 2022. Primary treatment was the therapy planned at the initial visit,while secondary treatment was subsequent treatment after follow-ups. Good anatomical outcomewas defined as vitreous clearing at last follow-up, while functional outcome was visual acuity (VA)improvement in LogMAR.
ResultsThis study included 83 patients (97 eyes), which is smaller than the previous study in our centerbefore the pandemic. Mean age was 54,28±8,57 years, with almost equal males and females. InitialVA was LogMAR 2,48 (0,15 – 2,80). The most frequent treatment for VH in PDR was vitrectomy(53,5%), followed by anti-VEGF injection, PRP laser, and observation. Glaucoma after vitrectomy wasthe most common complication (5,2%). Vitreous clearing was achieved in 85,5% of cases, which wassignificantly associated with vitrectomy surgery (p=0,013) and initial treatment time (p=0,023). TheVA improvement was LogMAR -0,48(-2,48–2,40) which was related to initial VA (p<0.05), yet therewas no significant association with treatment modality.
ConclusionVitrectomy is essential to achieve vitreous clearing in VH caused by PDR. Initial visual acuity, notthe type of treatment modality, is a significant factor in vision improvement.
The Correlation between Retinal Nerve Fibre Layer Thickness, Optic Nerve Head Parameter, and Related Risk Factor in Glaucoma Patient
Authors: Wardhana Arif Kusuma , Ekantini Retno , Gani Tatang Talka , Jati Krisna Dwi Purnomo 
Published: February 2024

Introduction & ObjectivesTo investigate the correlation between retinal nerve fibre layer (RNFL) thickness and the past RNFLthickness, related risk factor (gender, age, myopia, intraocular pressure (IOP), blood pressure). AndRNFL parameter (symmetricity and four quadrants RNFL thickness) and optic nerve head parameter(rim area and vertical cup disc ratio)
Methods39 right eyes of both sex and various age underwent examination including IOP measurement,subjective refraction for determining refractive error, and optical coherence tomography (OCT) forRNFL and ONH analysis. The follow up were done after one year.
ResultsThe RNFL symmetricity, superior, nasal, inferior, temporal RNFL thickness showed significancecorrelation with RNFL thickness (R= 0.487, p= 0.002), (R= 0.915, R= 0.749, R= 0.897, R= 0.702with p= <0.001), but not showed significance correlation with rim area and vertical cup disc ratio(R= 0.175, p= 0.286) and (R= -0.093, p= 0.574). A significance correlation also showed withincreasing age, gender, and systolic blood pressure (R= -0.387, p= 0.015), (R= 0.441, p= 0.005) and(R= -0.418, p= 0.008). But not showed significance correlation with history of past RNFL thickness,refractive error, IOP, and diastolic blood pressure (R= 0.258, p= 0.113), (R= 0.005, p= 0.975), (R=-0.234, p=0.152), and (R= 0.060, p=0.717).
ConclusionRNFL thickness measurements showed significance correlation with RNFL parameter. It is not clearif past RNFL thickness, refractive error and IOP related with RNFL thickness even showedsignificance correlation with age, gender, and systolic blood pressure.
Outlook of Diabetic Retinopathy Management through Universal Health Care in Indonesia from 2015 – 2020
Authors: Zaharo Alfia Fatma , Wardhana Firman Setya , Supanji  , Sasongko Muhammad Bayu 
Published: February 2024

Introduction & ObjectivesTo identify the National Health Expenditure associated with diabetic retinopathy (DR) from theperspective of Jaminan Kesehatan Nasional [JKN].
MethodsA dataset of 1% of all individuals registered in JKN database was used from 2015 to 2020. Weretrieved primary diagnosis with type 2 diabetes mellitus (T2DM) (ICD-10 E11) and/or T2DM withophthalmic complications (E11.3). Further diagnosis with DR (H36) was retrieved. Four groups ofmedical procedures related to DR management were developed according to Indonesian Case BaseGroups (INA-CBGs): diagnostic, laser photocoagulation and cryotherapy, minor (intravitrealinjection), and major surgical procedures (e.g., vitrectomy). We performed descriptive analyses forthe annual costs incurred for procedures, premium classifications, and regions.
ResultsOverall DR costs were US $41.5 million from 156,752 individuals with DR in JKN database sample.The total cost and per unit procedures cost specifically increased annually from 2015 to 2019 butdeclined substantially in 2020. The largest amount was spent on intravitreal injection ($36.3 million[87.5%]), whereas vitrectomy was the least ($145.0 million [0.3%]). Region 1 (Java Island) with nonbeneficiariesof government subsidies (PBPU and PPU) was the major number of claims ($12.5million [30.1%] and ($7.3 million [17.7%]), while beneficiaries of government subsidies (PBI) outsideJava Island, conversely, were under average.
ConclusionThere was significant increase in health expenditure associated with DR in Indonesia from 2015 to2019, but decreased in 2020 possibly due to COVID-19 pandemic. Majority of funding was spent totreat severe spectrum of DR and concerned in urban area.
Comparation of Bevacizumab Intravitreal Injection Effects with and without Yellow Subthreshold Micropulse Laser (577-nm) Combination on Central Macular Thickness and Best Corrected Visual Acuity of Mild-Moderate Diabetic Macular Edema Patients
Authors: UTAMI ALIA NESSA , Djatikusumo Ari , Khoe Levina Chandra 
Published: February 2024

Introduction & ObjectivesThe management of macular edema is constantly evaluated, with anti-VEGF therapy being the firstline. Subthreshold micropulse laser (SML) has been proposed as alternative adjuvant. Previousretrospective studies demonstrated the effectiveness of 577-nm SML as monotherapy in macularedema with CMT below 400 ?m. However, prospective data on the effectiveness of SML as adjuvantis lacking. The aim is to assess the effect of the combination of bevacizumab and 577-nm SML lasercompared to bevacizumab monotherapy on central macular thickness and visual acuity in mildmoderatediabetic macular edema patients.
MethodsA prospective randomized clinical trial was performed on diabetic macular edema patients withmacular thickness range of 300-600 ?m. Subjects are divided into two groups. The control groupreceived a standard protocol and the study group received a yellow SML laser adjuvant one weekafter injection. Patients underwent follow-up assessment of visual acuity and central macularthickness at 28 and 35 days post-injection.
Results26 subjects were equally divided into study and control groups. Significant decrease in CMT werefound in study group (p=0.011 and 0.014) and the control group (p=0.006 and p=0.001). However,there was no significant difference in ?CMT values between the two groups in the 28-day (p=0.317)and 35-day controls (p=0.84). There was no difference in ?BCVA ETDRS between the study andcontrol groups at 28 days (p=0.568) and 35 days (p=0.128) after injection.
ConclusionThe combination of SML and intravitreal bevacizumab can reduce central macular thickness andimprove visual acuity but there was no significant difference with standard monotherapy.
THE ASSOCIATION BETWEEN ATRIAL FIBRILLATION AND CENTRAL RETINAL ARTERY OCCLUSION: A META-ANALYSIS AND SYSTEMATIC REVIEW
Authors: Amelia Yufilia Suci , Alberta Ivana Beatrice , Angelia Maria , Pratama Kevin Gracia 
Published: February 2024

Introduction
Central retinal artery occlusion (CRAO) is a condition where the central retinal artery is blocked. Atrial Fibrillation (AF) is commonly associated with retinal embolism that originates anywhere between the heart and the ophthalmic artery. This study aims to explore the incidence of AF in CRAO.
Methods
A systematic search was performed in three databases: Pubmed, EBSCO host, and Proquest. Newcastle-Ottawa Scale was used to assess the risk of bias in the study included.
Results
Our systematic review comprises six studies, 4 studies included CRAO patients as the study population and AF as the endpoint, and the other 2 studies with CRAO as the endpoint. Meta-analysis of the first group resulted in a significantly favorable AF incident after CRAO with an odds ratio (OR) of 1.46 (95% CI 1.17-1.81, p=0.0007). The second metaanalysis supports CRAO with an OR of 4.86 (95% CI 2.30-10.28, p<0.0001).
Discussion
Our study indicates that AF is a significant risk factor for CRAO. Extended cardiac monitoring may play a crucial diagnostic role in CRAO patients, and longer-term monitoring (23 years) may be a reasonable option as part of the diagnostic workup. Short-term monitoring alone may fail to detect a significant proportion of patients with underlying AF.
Conclusions
It is crucial to identify AF in preventing ocular infarction. This study revealed that AF was identified as a risk factor in patients with CRAO and vice versa.
A systematic review comparing Mytomicyn-C subtenon injection to sponge during trabeculectomy in open angle glaucoma
Authors: Ethelind Rachel , Puspa Prizka Avilia , Santoso Wildan Iman 
Published: February 2024

Introduction & ObjectivesMitomycin-C (MMC) is an effective agent to prevent scarring during the healing process followingtrabeculectomy procedure by inhibiting the multiplication of cells producing scar tissue. The aim ofthis study is to compare the efficacy of Mitomycin-C (MMC) delivered by either subtenon injection orsponge application during trabeculectomy surgery in open angle glaucoma patients.
MethodsA systematic search was done using several databases including Pubmed, Medline, Embase, Scopus,and Jstor. Inclusion criteria were open angle glaucoma patients underwent trabeculectomy surgery,given either MMC via subtenon or sponge application, article in English, Randomized ControlledTrial (RCT) studies which published in the last 10 years. Intra-Ocular Pressure (IOP), EndothelialCell Counts (ECC) and Bleb Morphologic features with at least 1 month follow-up were evaluated.
ResultsTwo RCT studies were included in this study. Both studies demonstrated that sub-tenon injectionand sponge application has no significant difference regarding IOP reduction from the baseline.Regarding morphologic features, both studies favor subtenon to conventional sponge application.Lastly, ECC in both studies conclude that there was no marked differences.
ConclusionThe outcome of administration of MMC through subtenon injection and sponge application werecomparable to one another. However, less vascularization are shown in subtenon injection group.
Automation of the technological processes of wastewater treatment: case study of the Minsk wastewater treatment plant of UE Minskvodokanal
Authors: Иванович В.В. , Гуранчик А.Г. , Дубовик О.С. , Ануфриев В.Н. 
Published: February 2024

Приведен опыт УП «Минскводоканал» по разработке и организации автоматизированных систем управления технологическим процессом очистки сточных вод на примере нескольких сооружений Минской очистной станции. Описаны цели и задачи, которые выполняются АСУ ТП на станции. Представлены структура и режимы работы реализованных систем. Детально рассмотрены этапы процесса очистки сточных вод: процеживание на решетках, удаление и обработка песка, подача и распределение воздуха по секциям аэротенков. В рамках автоматизации представленных стадий очистки описано общее построение АСУ ТП, приведены особенности эксплуатации, используемые объекты и режимы автоматизации. Особое внимание уделено необходимости простых и надежных алгоритмов управления. Конечной целью модернизации АСУ ТП Минской очистной станции является максимальная степень автоматизации и диспетчеризации, охватывающие всю технологическую цепочку очистки сточных вод и обработки осадка и основанные на простых и надежных принципах.
The experience of UE Minskvodokanal in developing and establishing of automated control systems for the technological process of wastewater treatment is presented using the example of several structures of the Minsk wastewater treatment plant. The goals and tasks performed by the automated process control systems at the plant are described. The structure and operating modes of the implemented systems are presented. The stages of the wastewater treatment process are considered in detail: screening, sand removing and processing, supplying and distributing air across sections of the aeration tanks. As part of the automation of the presented treatment stages, the general design of the automated process control system is described, the operating features, the objects used and automation modes are given. Special attention is paid to the need for simple and reliable control algorithms. The ultimate goal of upgrading the automated process control system of the Minsk wastewater treatment plant is the maximum degree of automation and supervisory control covering the entire technological chain of wastewater and sludge treatment based on the simple and reliable principles.
Aspects of designing wastewater treatment facilities in terms of the BAT process indicators: priorities and consequences
Authors: Самбурский Г.А. , Погорелый А.М. , Леонтьева С.В. , Никитина С.В. 
Published: February 2024

Переход на концепцию технологического нормирования происходит одновременно с реализацией ряда федеральных проектов экологической направленности, в том числе входящих в национальный проект «Экология». Учитывая то, что водоканалы с позиций Росприроднадзора являются одними из основных загрязнителей водных объектов, строительство новых и модернизация действующих очистных сооружений находится в фокусе органов власти, контролирующих органов и, естественно, самих организаций, которые занимаются эксплуатацией очистных сооружений канализации. В статье рассмотрены потенциальные и возможные несоответствия текущих ожиданий по поводу проектирования, исходя из технологических показателей наилучших доступных технологий и самой концепции использования наилучших доступных технологий, которая подразумевает не статичность, а развитие и последовательное ужесточение тех самых технологических показателей.
Switching to the concept of the technological regulation occurs simultaneously with implementing a number of federal environmental projects including those included in the Ecology National Project. Considering that water utilities, through the spectacle of Rosprirodnadzor are among the main polluters of water bodies, the construction of new and upgrade of the existing treatment facilities is the focus of public authorities, regulators and, naturally, the wastewater facilities operators themselves. The paper considers potential and possible inconsistencies of the current design expectations based on the technological indicators of the best available technologies and the very concept of using the best available technologies that does not imply stasis but the development and consistent tightening of those same technological indicators.
Hubungan Kegiatan Ekstrakurikuler dengan Psychological Well-Being Mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Sam Ratulangi
Authors: Gunawan Felicia A. , Opod Hendri , David Lydia E. V. 
Published: February 2024

Abstract: Pre-Clinical Students tend to experience a decline in quality of life and well-being due to different responsibilities in curriculum, tasks, and demands during their studies. Extracurricular activities involve aspects of perseverance, empathy, and mindfulness, where these elements can prevent, and even enhance, an individual's psychological well-being (PWB). This study aimed to evaluate the correlation between extracurricular activities and PWB in pre-clinical medical students of Universitas Sam Ratulangi, Manado. This was a quantitative approach study employing data collection through the administration of the PWB scale (PWBS) questionnaire with 84 items developed by Ryff. The results obtained a total of 155 respondents participated in this study. The analysis did not reveal any correlation between participation in extracurricular activities and the dimensions of PWB. Albeit, a correlation was identified between the duration of involvement in extracurricular activities and specific dimensions of PWB (p<0.05). In conclusion, there is no correlation between extracurricular activities and PWB. However, there is a correlation between the duration aspect of involvement in extracurricular activities and PWB dimensions, especially the dimensions of positive relations with others and personal growth.
Keywords: extracurricular activities; psychological well-being; duration aspect

Abstrak: Mahasiswa Program Studi Pendidikan Dokter cenderung mengalami penurunan kualitas hidup dan kesejahteraan karena adanya perbedaan dari segi kurikulum, tugas, dan tuntutan dalam menjalani studi. Kegiatan ekstrakurikuler merupakan suatu kegiatan yang melibatkan aspek ketekunan, empati, dan mindfulness, di mana aspek-aspek ini dapat mencegah penurunan, bahkan meningkatkan psychological well-being (PWB) seseorang. Penelitian ini bertujuan untuk mengevaluasi korelasi antara kegiatan ekstrakurikular dengan PWB pada mahasiswa pre-klinik Universitas Sam Ratulangi, Manado. Jenis penelitian ialah kuantitatif dengan metode pengambilan data menggunakan kueisioner PWB scale (PWBS) 84–items oleh Ryff. Hasil penelitian mendapatkan 155 responden yang terlibat dalam penelitian ini yang mengikuti kegiatan ekstrakurikuler. Tidak ditemukan adanya korelasi antara kegiatan ekstrakurikuler dengan dimensi PWB, tetapi terdapat korelasi antara aspek durasi keterlibatan ekstrakurikuler dengan dimensi-dimensi PWB tertentu (p<0,05). Simpulan penelitian ini ialah tidak terdapat hubungan antara ekstrakurikuler dengan PWB, tetapi terdapat hubungan antara aspek durasi keterlibatan ekstrakurikuler dengan dimensi PWB, terkhususnya dimensi positive relations with others dan personal growth.
Kata kunci: aktivitas ekstrakurikuler; psychological well-being; aspek durasi
Curso Técnico em Biotecnologia Instituto Federal de Educação Ciência e Tecnologia – Campus Porto Alegre – 20 anos de história
Authors: Tallini Karin , Liliane Madruga Prestes  , Paulo Artur Konzen Xavier de Mello Silva  
Published: February 2024

Este trabalho apresenta uma breve reflexão acerca dos 20 anos do Curso Técnico em Biotecnologia do IFRS - Campus Porto Alegre. O curso teve o início de suas atividades em 1996 na Escola Técnica de Comércio da Universidade Federal do Rio Grande do Sul e hoje faz parte do Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul (IFRS) – Campus Porto Alegre. O trabalho relata sua origem, contextualizando o estudo: da Escola de Artes e Ofícios à oferta do Curso Técnico de Biotecnologia no IFRS - Campus Porto Alegre, assim como a sua organização curricular ao longo do período. Além disso, este artigo menciona as reflexões acerca dos pressupostos teóricos e metodológicos e das práticas educativas voltadas à formação do indivíduo como técnico em Biotecnologia, além das atividades de ensino, pesquisa e extensão e desafios na carreira na atualidade.