bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing operational performance through industry 4.0: a comprehensive model for data reliability and OEE enhancement
Authors: Anwar Meddaoui , Ahmed En-nhaili , Abdelhamid Zaki 
Published: February 2024

Abstract
In today's industrial context, three key elements are guiding the course of small and medium-sized enterprises (SMEs) towards improved productivity, efficient operations, and sustainable growth. The introduction of Industry 4.0 signifies a groundbreaking shift, integrating state-of-the-art technologies into manufacturing processes and propelling industries towards heightened efficiency and competitiveness. This article deals with the crucial role of productivity measurement in SMEs and examines the impact of data reliability on operational performance assessment. It explores the strategic use of Industry 4.0 tools to enhance data reliability in processes like production, quality, and maintenance. The research focuses on designing a comprehensive model for data collection, reliability, and utilization, ultimately aiming to improve Overall Equipment Effectiveness (OEE) within SMEs. By showcasing the synergistic integration of Industry 4.0 advancements, the article provides practical insights for SME stakeholders to optimize operational performance. The proposed model contributes to the understanding and implementation of efficient methodologies for data management, fostering sustainable improvements using calculation of OEE within SMEs. The case study was conducted in a plastics manufacturing SME that produces components for various industries. These findings can be enhanced and improved through additional case studies to refine the proposed model.
First in vitro cell co-culture experiments using laser-induced high energy electron FLASH irradiation – potential for anti-cancer therapeutic strategies
Authors: Sima Felix , Orobeti Stefana , Sima Livia Elena , (Porosnicu) Ioana Dinca , Diplasu Constantin , Giubega Georgiana , Cojocaru Gabriel , Ungureanu Razvan , Dobrea Cosmin , Serbanescu Mihai , Mihalcea Alexandru , Stancu Elena , Staicu Cristina Elena , Jipa Florin , Bran Alexandra , Axente Emanuel , Sandel Simion , Zamfirescu Marian , Tiseanu Ion 
Published: February 2024

Abstract
Radiation delivery at ultra-high dose rates (UHDRs) demonstrated its potential to be used as a new anti-cancer therapeutic strategy. The FLASH effect induced by UHDR irradiation was shown to maintain anti-tumor efficacy while reducing normal tissue toxicity that limits the use of conventional radiotherapy, however, the FLASH effect was difficult to demonstrate in vitro. The new high-intensity petawatt laser-driven accelerators can deliver very high energy electrons (VHEE) at dose rates as high as 1013 Gy/s in very short pulses (10− 13 s). We present here the first in vitro experiments carried out on cancer cells and normal non-transformed cells exposed concurrently to laser-plasma accelerated (LPA) electrons. Specifically, melanoma cancer cells and normal melanocyte co-cultures grown in chamber slides were simultaneously irradiated by LPA electrons. Non-uniform dose distribution on cell cultures was revealed by gafchromic films placed behind the chamber slide supporting the cells. In parallel experiments, cell co-cultures were exposed to pulsed X-ray irradiation, serving as positive controls for radiation-induced nuclear DNA double-strand breaks. By measuring the impact on discrete areas of the cell monolayers, it was revealed that the highest propensity of damaged DNA-containing nuclei was achieved by LPA electrons at a cumulated dose of one order of magnitude lower than the dose obtained by pulsed X-ray irradiation. Interestingly, on certain discrete areas, we observed that LPA electron exposure had a different pattern of DNA damage impact on healthy NHEM melanocyte cells than on the A375 melanoma cells – normal cells were less affected than cancer cells.
A pan-cancer analysis has uncovered CCDC58, a mitochondrial gene associated with epilepsy, as a potential prognostic and immunotherapeutic biomarker for various cancer types, including gliomas
Authors: You Zhipeng , Huang Cong , Li Jiran , Liu Yang , Wei Fan , Fan Zhijie , Liu Xingan , Sun Jiahang 
Published: February 2024

Abstract

Approximately 30 percent of individuals with intracranial tumors may experience seizures. Seizures can often be the first clinical symptom of glioblastoma. Mitochondrial dysfunction plays an extremely significant role in both carcinogenesis and epilepsy. Therefore, exploring the common pathogenesis of glioma and epilepsy will help to identify potential therapeutic targets for both. We first screened the eight MitDEGs most closely related to epilepsy using the Epilepsy and Mitochondrial Gene Database, and by building a diagnostic model of the disease, we found that CCDC58 had the highest diagnostic value in epilepsy, and CCDC58 has been seldom reported in epilepsy as well as in other diseases. Therefore, we chose CCDC58 as a key molecule for subsequent pan-cancer analysis. Based on our research, CCDC58 exhibits significant expression in several types of cancer, including gliomas, and a robust correlation exists between CCDC58 expression and cancer prognosis. Age, Race, and WHO classification are among the clinicopathological characteristics that have been linked to the gene expression level of CCDC58 in gliomas. Additionally, extensive pan-cancer analyses have revealed a substantial association between the degree of immune cell infiltration into the tumor and the epilepsy-associated mitochondrial gene CCDC58, as well as important indicators such as TMB and MSI. Our in vitro experiments confirm that CCDC58 acts as an oncogene, promoting the growth, migration, and invasiveness of glioma cells. In conclusion, our results suggest that the epilepsy-associated mitochondrial gene CCDC58 shows potential as a prognostic and immunotherapeutic biomarker for various cancer types, including glioma.
Hybrid Particle Swarm Optimization Coupled by Machine Learning Technique for Estimating Relative Permeability and Capillary Pressure Functions During Low-Salinity Flood
Authors: Khosravi Razieh , Simjoo Mohammad , Chahardowli Mohammad 
Published: February 2024

Abstract
Experimental methods to estimate the relative permeability and capillary pressure data are expensive and time-consuming, thus evolutionary and stochastic algorithms to estimate these parameters could be a promising solution. This study aims to determine the relative permeability and capillary pressure functions of a heterogeneous sandstone core in the presence and absence of clay during low-salinity water flood. The relative permeability and capillary pressure data were determined by automatic history matching recovery factor and pressure drop results from previously lab-reported data, through coupling a simulator with the particle swarm optimization algorithm. A series of correlations were proposed based on multiple-linear regression for relative permeability parameters at the desired low-salinity conditions. They were validated against experimental results of no clay and clayey formation with regression of 95% and 97%, and MSE of 1.2E-04 and 8E-05. One single curve for relative permeability and capillary pressure obtained from averaging methods was assigned to the grid cells for core scale low-salinity flood simulation. Accordingly, the effect of salinity and clay content on the obtained curves was investigated. The proposed hybrid method could be a suitable tool to estimate relative permeability and capillary pressure functions at the core and field level of the water-based EOR methods.
Characteristics of Historical Earthquake Sequences and Seismogenic Background around Jiaokou Reservoir, eastern China
Authors: Gao Yajing , Wang Zhenjie , Zhang Qi , Sun Yunqiang 
Published: February 2024

Abstract

The Jiaokou Reservoir area is one of the areas with relatively frequent seismicity in Zhejiang, eastern China. We made an analysis and summary of seismicity near Jiaokou Reservoir from 1983 to 2022 using data such as seismic waveforms from stations, earthquake catalogs, and seimic observation reports. Firstly, we analyzed spatio-temporal variations of historical seismicity and b-values of earthquake sequences around Jiaokou Reservoir in different periods. Then, we used HypoDD method to relocate events after 2008, and used CAP and HASH methods to obtain focal mechanisms of events with ML ≥ 3.0 after 2008. Finally, we analyzed the characteristics of earthquake distribution, stress field, seismogenic structures, and seismogenic mechanisms in the region. The main views are as follows: (1) The relocation results indicate that the narrow-band distribution characteristics of earthquake sequences after 2008 around Jiaokou Reservoir are apparent, with a strike of roughly NW-SE 110° and a high dip angle of roughly SW 70-80°. (2) The focal mechanisms show that these events are basically left-lateral strike-slip rupture form. Combined with relocation results, it is inferred that the seismogenic fault is close to a nodal plane with a strike of 99°, dip of SW 73°, and rake of -5°. (3) P-axis directions of Jiaokou events are NE-SW, and T-axis directions are NW-SE, with relatively small dip angles, which shows the near horizontal compression in NE-SW and near horizontal tension in NW-SE. The two directions of tension and compression axes are consistent with the stress field directions of eastern China. (4) Combined with the tectonic features of fault zones around Jiaokou Reservoir area, it is inferred that the main seismogenesis structures of events after 2008 may be minor strike-slip faults with a strike of NW-SE (about 99-110°) and a high dip angle of SW (about 70-80°), which are located in Changxing-Fenghua fault zone system. (5) Under the influence of water infiltration and corrosion in Jiaokou Reservoir, the fracture strength of underground rock decreases, the fault plane softens, and the friction strength decreases. Due to far-field tectonic loading and interaction between Changxing-Fenghua and Yuyao-Lishui fault systems, stress on faults in Changxing-Fenghua fault system had reached a critical and unstable state, triggering earthquakes around the reservoir. Jiaokou earthquakes belong to the "triggered type".
Attending a patient education seminar before body-contouring surgery and its effect on total time admitted to hospital and postsurgical opioid use - a retrospective cohort study
Authors: Poulsen Signe , Sollie Martin 
Published: February 2024

Abstract
Objective: To investigate whether attending a one-day patient education seminar before body-contouring surgery after massive weight loss surgery could affect postsurgical opioid use and the total time admitted to the hospital. Secondly, we wanted to see if other patient characteristics could influence the above variables.
Methods: We conducted a retrospective chart review of all patients undergoing body-contouring surgery at our department from April 2017 to December 2020. All patients had been invited to attend our patient education seminar prior to surgery, with around half accepting the invitation.
Results: We included a total of 276 patients. One hundred fifty patients had attended the patient education seminar and were compared to the one hundred and twenty-six who did not participate. Attending a patient education seminar prior to body-contouring surgery was associated with reduced total admission time after surgery. It did not affect the use of postoperative analgesics. Previous gastric bypass and previous body-contouring surgery were associated with a shorter duration of stay. Males reported higher use of analgesics compared to women. More extensive surgery, such as abdominoplasty and circular body lift, was associated with a longer stay duration than more minor procedures such as thighplasty, upper arm lift, and chest correction.
Conclusion: Our results indicate that attending a patient education seminar could reduce the total admission time in relation to their body-contouring surgery. As a result of this study, we have made participation in the patient education seminar mandatory before body-contouring surgery.
Practice implications: Healthcare personnel should be aware of the importance of proper pre-operative preparation and, if feasible, arrange a patient education seminar. They should also be aware of other factors that could affect hospital admission time, such as previous gastric bypass and previous body-contouring surgery. The area of surgery and gender of the patients could also affect the need for analgesics after surgery.
Comparison of prognosis for locally advanced T4b rectal cancer with different pelvic compartment involvement treated using neoadjuvant chemoradiotherapy and implications for refinement of the current TNM staging system
Authors: Zhang Yang-zi , Song Maxiaowei , Li Shuai , Tie Jian , Wang Hong-zhi , Geng Jian-hao , Zhu Xiang-gao , Liu Zhi-yan , Li Yong-heng , Wu Ai-wen , Cai Yong , Wang Wei-hu 
Published: February 2024

Abstract
Purpose
Although classified as one stage, T4b rectal cancer actually represents a group of heterogeneous diseases. Our study aimed to assess the prognosis of locally advanced T4b rectal cancer involving inferior pelvic and other pelvic compartments. This information may be helpful in further refinement of the current TNM staging system.
Methods
We retrospectively analysed data from 195 patients with magnetic resonance imaging-identified locally advanced T4b rectal cancer who received neoadjuvant chemoradiotherapy between January 2010 and December 2019. 104 patients had only inferior pelvic compartment involvement (group A) while 91 patients had anterior, posterior or lateral pelvic compartment involvement (group B). Short-term and long-term outcomes were compared between the two groups.
Results
After neoadjuvant therapy, 80.8% of patients (84/104) in group A and 92.3% of patients (84/91) in group B underwent surgery. The R0 resection rates were 97.6% and 89.3%, respectively (P = 0.061). In addition, 8.7% patients (9/104) in group A achieved clinical complete response and adopted watch-and-wait strategy. Patients in group A had significantly superior 5-year progression-free survival (PFS) (67.8% vs. 55.5%, P = 0.032) and overall survival (OS) (89.6% vs. 71.8%, P = 0.001) than group B. Multivariable Cox regression analysis also identified pelvic compartment involvement classification as an independent predictor of OS (hazard ratio 3.477, P = 0.004).
Conclusion
T4b rectal cancers with only inferior pelvic compartment involvement had superior prognosis than those involving other pelvic compartments. These differences should be investigated further and taken into consideration in refinement of the TNM staging system.
Theoretical and experimental study on ballistic performance of CFRP laminates under high velocity impact
Authors: Zhang Jian , Yao Changfeng , Dai Hui , Xin Hongmin , Li Guangping 
Published: February 2024

Abstract
This work investigated the ballistic performance of CFRP laminates with different thicknesses using a ballistic gun testing apparatus. By combining high-speed camera and recovered target plates, the failure mechanisms of CFRP laminates under high-velocity impact were revealed. The results showed that due to the combined action of compressive and shear loads, fiber fracture, matrix crushing, and splitting along the fiber direction mainly occurred on the impact face of the target plate. The back face of the target plateprimarily appeared fiber fracture and delamination failure under tensile loading condition. When the projectile impact velocity exceeds the ballistic limit, the energy absorption value of the target plate becomes relatively flat, and the average energy absorption and the ballistic limit of CFRP laminates of the target plate increases with the increase of plate thickness. The rigid projectile perforation model by Chen & Li can predict the ballistic performance of spherical projectiles impacting CFRP laminates at high velocity well. Furthermore, it’s better to match the theoretical prediction model of the target plate inertia effect and the experimental data.
Chemically Modified MicroRNA Delivery via DNA Tetrahedral Frameworks for Dental Pulp Regeneration
Authors: Wei Xiaoling , Xu Huaxing , Zhou Mengqi , Zhou Qiangqiang , Li Mingqiang , Liu Yuehua 
Published: February 2024

Abstract
Dental pulp regeneration is a promising strategy for addressing tooth disorders. Incorporating this strategy involves the fundamental challenge of establishing functional vascular networks using dental pulp stem cells (DPSCs) to support tissue regeneration. Current therapeutic approaches lack efficient and stable methods for activating DPSCs. In the study, we used a chemically modified microRNA (miRNA)-loaded tetrahedral-framework nucleic acid nanostructure to promote DPSC-mediated angiogenesis and dental pulp regeneration. Incorporating chemically modified miR-126-3p into tetrahedral DNA nanostructures (miR@TDNs) represents a notable advancement in the stability and efficacy of miRNA delivery into DPSCs. These nanostructures enhanced DPSC proliferation , migration, and upregulated angiogenesis-related genes, enhancing their paracrine signaling effects on endothelial cells. This enhanced effect was substantiated by improvements in endothelial cell tube formation, migration, and gene expression. Moreover, in vivo investigations employing matrigel plug assays and 1 ectopic dental pulp transplantation confirmed the potential of miR@TDNs in promoting angiogenesis and facilitating dental pulp regeneration. Our findings demonstrated the potential of chemically modified miRNA-loaded nucleic acid nanostructures in enhancing DPSC-mediated angiogenesis and supporting dental pulp regeneration. These results highlighted the promising role of chemically modified nucleic acid-based delivery systems as therapeutic agents in regenerative dentistry and tissue engineering.
Experiences of externalisation in recovery from anorexia nervosa: a reflexive thematic analysis
Authors: Cripps Sophie Charlotte , Serpell Lucy , Pugh Matthew 
Published: February 2024

Abstract

Background: Many individuals perceive anorexia nervosa (AN) as a part of their personal identity. Externalisation involves making the “problem” a separate entity, external to the individual. It is an attitude taken by the client and family, stimulated by the therapist to build engagement with treatment and supportive relationships around the individual. Externalisation is used in NICE recommended treatments for AN, however there is a paucity of research exploring the therapeutic effects of this approach. This research aims to address this gap by exploring the role of externalisation in treatment for AN to elicit an understanding of how this practice can help and hinder recovery.
Methods: This qualitative study used a reflexive thematic analysis. Thirteen adults with a current and/ or past diagnosis of AN participated in semi-structured interviews.
Analysis: Participants described their experience of externalisation as a journey which is depicted by five themes. ‘Separation’ portrays the separation of the individual’s internal dialogue from the ‘self’. ‘Making sense of AN’ describes the experience of language and exercises used to separate AN. ‘A third entity in relationships’ illustrates the impact of externalisation on relationships. ‘A relationship with AN’ elucidates the use of externalisation to explore the function and effects of the individual’s relationship to AN. ‘Managing AN’ explains the experience of a continued relationship with the externalised AN entity post-treatment.
Conclusions: The notion of separating one’s internal dialogue from one’s concept of self may initially be rejected. As the individual develops trust in the therapist, they may begin to realise two sides within them, the “healthy self” (HS) and the “anorexia voice” (AV). However, social-cultural discourses around eating contribute to ambiguity during the dichotomous categorisation of thoughts. Externalising practices were most helpful when led by the individual using their own experience-near language. Externalisation which did not permit the individual to feel seen as a person beyond AN was hindering to recovery. Therapists, treatment teams and family members should be cognisant of the emotional effects of language used to externalise AN. Future research should elicit an understanding of the experience of externalisation among a diverse sample of young people and families.
Analysis of lettuce transcriptome reveals the mechanism of different light/dark cycle in promoting the growth and quality
Authors: Dai Mengdi , Tan Xiangfeng , Ye Ziran , Chen Xuting , Zhang Yi , Ruan Yunjie , Ma Bin , Kong Dedong 
Published: February 2024

Abstract
Light/dark cycle plays a crucial role in controlling the production and quality of vegetables. However, the mechanism of light/dark cycle on vegetable growth and quality is scarce studied. To investigate the impact of light/dark cycle on lettuce growth and quality, we designed three diel scenarios, including 16 hours of light and 8 hours of darkness (1C), 12 hours of light and 6 hours of darkness (1.3C), and 8 hours of light and 4 hours of darkness (2C). Lettuce grew taller under the 2C scenario than under 1C light cycle scenarios. Under the 2C scenario, the lettuce leaves exhibited greater enhancements in the levels of soluble protein, soluble sugar, and carotenoid content compared to the other scenarios. By comparing the expression levels under different diel scenarios (1C vs 1.3C, 1C vs 2C, and 1.3C vs 2C), we identified 7,209 differentially expressed genes (DEGs). Additionally, 3 gene modules that were closely related to light/dark cycle of lettuce were selected by WGCNA analysis. The eigengenes of three gene modules were enriched in plant hormone signal transduction, sphingolipid metabolism, and nucleocytoplasmic transport pathways. Through network analysis, we identified six hub genes (CIP1, SCL34, ROPGEF1, ACD6, CcmB, and Rps4) in the three gene modules, which were dominant in plant circadian rhythms and greatly affected lettuce growth. qRT-PCR analysis confirmed the diurnal response patterns of the 6 hub genes in different treatments were significant. This study intensively enhanced our comprehension of the light/dark cycle in the growth morphology, nutritional quality, and metabolic pathways of lettuce.