bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of substance use on posttraumatic stress disorder symptoms and treatment discontinuation
Authors: Stevenson Brittany L. , Lee Jenny Y. , Oslin David W. , Polusny Melissa A. , Kehle‐Forbes Shannon M. 
Published: December 2023

AbstractThis study examined the impact of ongoing substance use during posttraumatic stress disorder (PTSD) and substance use disorder (SUD) treatment on PTSD symptoms and treatment discontinuation. The study represents a secondary analysis of U.S. military veterans (N = 183) who participated in a randomized clinical trial for the treatment of both PTSD and SUD. Veterans mostly identified as Black (53.8%) or White (41.9%) and male (92.4%). Substance use, PTSD symptoms, and treatment discontinuation were measured at 4‐week intervals throughout treatment. Predictors were the percentage of days with alcohol, cannabis, and other substance use (primarily cocaine and opioids) and the average number of alcoholic drinks per drinking day. Outcomes were PTSD symptoms and treatment discontinuation at concurrent and prospective assessments. Multilevel models accounted for the nested structure of the longitudinal data. Alcohol, cannabis, and other substance use did not predict PTSD symptoms or treatment discontinuation prospectively. Concurrently, we observed that as a participant's percentage of drinking days increased by 34.7% (i.e., 1 standard deviation), PTSD symptoms during the same period were 0.07 standard deviations higher (i.e., 1 point on the PCL), B = 0.03, p = .033. No other substances were related to PTSD symptoms concurrently. The findings demonstrate that PTSD symptoms improved regardless of substance use during exposure‐based PTSD and SUD treatment, and treatment discontinuation was not associated with substance use. This study suggests that substance use during treatment cannot directly explain the poorer treatment outcomes observed in the literature on comorbid PTSD/SUD compared to PTSD‐only populations.
Current Practices in Voice Data Collection and Limitations to Voice AI Research: A National Survey
Authors: Evangelista Emily , Kale Rohan , McCutcheon Desiree , Rameau Anais , Gelbard Alexander , Powell Maria , Johns Michael , Law Anthony , Song Phillip , Naunheim Matthew , Watts Stephanie , Bryson Paul C. , Crowson Matthew G. , Pinto Jeremy ,   Bridge2AI‐Voice, Bensoussan Yael 
Published: December 2023

IntroductionAccuracy and validity of voice AI algorithms rely on substantial quality voice data. Although commensurable amounts of voice data are captured daily in voice centers across North America, there is no standardized protocol for acoustic data management, which limits the usability of these datasets for voice artificial intelligence (AI) research.ObjectiveThe aim was to capture current practices of voice data collection, storage, analysis, and perceived limitations to collaborative voice research.MethodsA 30‐question online survey was developed with expert guidance from the voicecollab.ai members, an international collaborative of voice AI researchers. The survey was disseminated via REDCap to an estimated 200 practitioners at North American voice centers. Survey questions assessed respondents' current practices in terms of acoustic data collection, storage, and retrieval as well as limitations to collaborative voice research.ResultsSeventy‐two respondents completed the survey of which 81.7% were laryngologists and 18.3% were speech language pathologists (SLPs). Eighteen percent of respondents reported seeing 40%–60% and 55% reported seeing >60 patients with voice disorders weekly (conservative estimate of over 4000 patients/week). Only 28% of respondents reported utilizing standardized protocols for collection and storage of acoustic data. Although, 87% of respondents conduct voice research, only 38% of respondents report doing so on a multi‐institutional level. Perceived limitations to conducting collaborative voice research include lack of standardized methodology for collection (30%) and lack of human resources to prepare and label voice data adequately (55%).ConclusionTo conduct large‐scale multi‐institutional voice research with AI, there is a pertinent need for standardization of acoustic data management, as well as an infrastructure for secure and efficient data sharing.Level of EvidenceLevel 5 Laryngoscope, 2023
The Larynx is Protected from Secondary and Vertical Papillomavirus Infection in Immunocompetent Mice
Authors: King Renee E. , Rademacher Josef , Ward‐Shaw Ella T. , Hu Rong , Bilger Andrea , Blaine‐Sauer Simon , Spurgeon Megan E. , Thibeault Susan L. , Lambert Paul F. 
Published: December 2023

ObjectiveMouse papillomavirus MmuPV1 causes both primary and secondary infections of the larynx in immunocompromised mice. Understanding lateral and vertical transmission of papillomavirus to the larynx would benefit patients with recurrent respiratory papillomatosis (RRP). To test the hypothesis that the larynx is uniquely vulnerable to papillomavirus infection, and to further develop a mouse model of RRP, we assessed whether immunocompetent mice were vulnerable to secondary or vertical laryngeal infection with MmuPV1.MethodsLarynges were collected from 405 immunocompetent adult mice that were infected with MmuPV1 in the oropharynx, oral cavity, or anus, and 31 mouse pups born to immunocompetent females infected in the cervicovaginal tract. Larynges were analyzed via polymerase chain reaction (PCR) of lavage fluid or whole tissues for viral DNA, histopathology, and/or in situ hybridization for MmuPV1 transcripts.ResultsDespite some positive laryngeal lavage PCR screens, all laryngeal tissue PCR and histopathology results were negative for MmuPV1 DNA, transcripts, and disease. There was no evidence for lateral spread of MmuPV1 to the larynges of immunocompetent mice that were infected in the oral cavity, oropharynx, or anus. Pups born to infected mothers were negative for laryngeal MmuPV1 infection from birth through weaning age.ConclusionSecondary and vertical laryngeal MmuPV1 infections were not found in immunocompetent mice. Further work is necessary to explore immunologic control of laryngeal papillomavirus infection in a mouse model and to improve preclinical models of RRP.Level of EvidenceNA Laryngoscope, 134:2322–2330, 2024
Dry fruit shell‐derived biochar increases biosorption potential and detoxification of organic pollutants for land safety
Authors: Munir Neelma , Hanif Maria , Abideen Zainul , Seerat Ayesha , Hamid Maria , El‐Sheikh Mohamed A. , Radicetti Emanuele , Mancinelli Roberto , El‐Keblawy Ali 
Published: December 2023

AbstractThe increase in water pollution and land degradation ultimately reduces the supply of clean water for the growing population. Biochar produced from dry fruit shells is an effective adsorbent for organic pollutants. It can help reduce soil contamination and water pollution, making it an important option for land safety. For this experiment, dry fruit shell biochar was produced and activated chemically with 1 M KOH to increase the pollutants' removal efficiency. The efficiency of biochar as an adsorber of pollutants was assessed by characterizations of scanning electron microscope, Fourier transform infrared, and X‐ray diffraction (XRD) techniques. The peak of almond shell biochar was observed between 1033 and 1068 cm−1, while in pistachio, it was observed at 1458–1446 cm−1. Data extracted from XRD showed that most peaks were shifted after activation. For example, in walnut shell biochar, the peak shifted from 11° to 18° after biochar activation. The highest pollutant removal efficiency, such as 92%, 90%, and 87%, was observed in walnut shell biochar at 1, 2, and 3 mLL−1 adsorbate concentration, respectively. Pistachio shell biochar was most effective in the presence of the chemical activator to remove toluene and phenol organic contaminants. An increase in adsorbate concentration decreased the removal efficiency from 50% to 46% in activated almond shell biochar, 58% to 55% in activated pistachio shell biochar, and 55% to 54% in activated walnut shell biochar by 1 gL−1 of adsorbent. Kinetic and equilibrium data with different applied models established that the adsorption process was favorable, and models were fitted to the experimental setup. Biochar prepared from different dry fruit shells and their optimum activation can be used as bio‐sorbent for pollutants' removal and hence improved land development for agriculture and other industrial purposes.
Persistent hot spots of CO2 and CH4 in coastal nearshore environments
Authors: Asmala Eero , Scheinin Matias 
Published: December 2023

AbstractNearshore environments are typically supersaturated with the potent greenhouse gases methane and carbon dioxide, due to intense remineralization of the elevated supply of organic carbon in these systems. These environments are characterized by overlapping biogeochemical gradients and heterogeneous morphology, and the overall spatial variability in nearshore greenhouse gas concentrations remains unclear. We measured surface water partial pressures of carbon dioxide and methane synoptically with water quality parameters in the coastal Baltic Sea, covering two ice‐free seasons. The high‐frequency flow‐through data revealed sites with recurring very high partial pressures of carbon dioxide and methane (i.e., hot spots) scattered around the 50 km × 40 km study area, exceeding overall partial pressure averages by 455 μatm (CH4) and 2396 μatm (CO2). High partial pressures were linked with elevated inputs of allochthonous and autochthonous organic matter, underpinning the major role of organic enrichment of coastal environments in global carbon cycling.
Using the consolidated framework for implementation research (CFIR) to guide implementation of cardio‐oncology services
Authors: Clouser Jessica Miller , McMullen Colleen A. , Adu Akosua K. , Wells Gretchen , Arbune Amit , Li Jing 
Published: December 2023

AbstractIntroductionCardio‐oncology focuses on diagnosing and preventing adverse cardiovascular outcomes in cancer patients. Interdisciplinary cardio‐oncology services address the spectrum of prevention, detection, monitoring, and treatment of cancer patients at risk of cardio‐toxicity and aim to improve the continuum of cardiac care for oncology patients. The goal of this study was to engage clinician and administrative stakeholders to assess multilevel needs, barriers, and expectations regarding cardio oncology services.MethodsWe interviewed clinicians and administrators at an academic medical center using the Consolidated Framework for Implementation Research (CFIR) to understand multilevel determinants influencing cardio‐oncology service implementation. We also conducted a web‐based survey to assess the knowledge, attitude, and perceptions of cardio‐oncology services held by local and regional clinicians who may refer cardio‐oncology patients to the study site.ResultsMultiple facilitators to cardio‐oncology service implementation emerged. Interview participants believed cardio‐oncology services could benefit patients and the organization by providing a competitive advantage. A majority (74%) of clinicians surveyed thought a cardio‐oncology service would significantly improve cancer patients’ prognoses. Implementation barriers discussed included costs and a siloed organizational structure that complicated cross‐service collaboration. In the clinician survey, differences in the views toward cardio‐oncology services held by cardiology versus oncology providers would need to be negotiated in future cardio‐oncology service development. For example, while most providers accepted similar risk of cardio‐toxicity when consenting patients for cancer therapy in a curative setting, cardiologists accepted significantly higher levels of risk than oncologists in an incurable setting: 75% of oncologists accepted 1‐5% risk; 77% of cardiologists accepted ≥5% risk).ConclusionsParticipants supported implementation and development of cardio‐oncology services. Respondents also noted multi‐level barriers that could be addressed to maximize the potential for success. Engaging administrators and clinicians from cardiology and oncology disciplines in the future development of such services can help ensure maximal relevance and uptake.
Preparation of Phase‐Change Composite Aerogel Materials and Its Application in Solar Saline‐Alkali Water Desalination
Authors: Dong Weixiong , Cao Xulei , Yan Jiayu , Zhang Zhen , Zhang Tian , Qin Yan , Ren Tiantian , Ma Xiaojun , Meng Guihua , Liu Zhiyong , Wu Jianning 
Published: December 2023

AbstractSolar energy is an inexhaustible clean energy, and solar evaporation salt water desalination is a promising technology. However, the low evaporation efficiency caused by intermittent solar irradiation is still the main obstacle in the practical application of interface evaporation. A new type of interfacial evaporation material is developed by using the porous adsorption method to fill the phase change material (PCM) paraffin (IPW) into the halloysite nanotubes (HNTs), using polydopamine (PDA) as the photothermal material and encapsulation agent and bacterial cellulose (BC) as the carrier. The low‐temperature crosslinking method prepares the IPW@HNTs@ PDA‐BC phase change composite aerogel. The novel interfacial evaporation material preparation process is simple, and the aerogels can be prepared quickly under normal pressure, which overcomes the disadvantages of the traditional porous adsorption method and long‐time freeze‐drying of aerogels. Under 1 kW m−2 light, the evaporation rate of the PCM is 3.43 kg m−2 h−1, and the photothermal conversion efficiency is 95%. In the dark environment (10 min), the evaporation rate is 2.80 kg m−2 h−1, and the photothermal conversion efficiency is 52.8%. The material exhibits excellent evaporation in acidic, alkaline water, and industrial wastewater. Shortly, it can be used as a promising material for evaporating clean water.
Mass cytometry and transcriptomic profiling reveal PD1 blockade induced alterations in oral carcinogenesis
Authors: Dong Yunmei , Zhang Chengli , Mao Fei , Dan Hongxia , Zeng Xin , Ji Ning , Li Jing , Chen Qianming , Zhou Yu , Li Taiwen 
Published: December 2023

AbstractOral squamous cell carcinoma is the predominant subtype of head and neck squamous cell carcinoma, characterized by a challenging prognosis. In this study, we established a murine model of oral carcinogenesis using 4‐nitroquinoline‐1‐oxide (4‐NQO) induction to investigate the impact of immunotherapy on microenvironmental alterations. Mice in the precancerous condition were randomly divided into two groups: one receiving programmed death‐1 (PD1) monoclonal antibody treatment and the other, control immunoglobulin G. Our observations showed that while PD1 blockade effectively delayed the progression of carcinogenesis, it did not completely impede or reverse it. To unravel the underlying reasons for the limited effectiveness of PD1 blockade, we collected tongue lesions and applied mass cytometry (CyTOF) and RNA sequencing (RNA‐seq) to characterize the microenvironment. CyTOF analysis revealed an increased macrophage subset (expressing high levels of IFNγ and iNOS) alongside a diminished Th1‐like subset (exhibiting low expression of TCF7) and three myeloid‐derived suppressor cell subsets (displaying low expression of MHC Class II or IFNγ) following anti‐PD1 treatment. Notably, we observed an increased presence of cancer‐associated fibroblasts (CAFs) expressing collagen‐related genes after PD1 blockade. Furthermore, we found a negative correlation between the infiltration levels of CAFs and CD8+ T cells. These findings were validated in murine tongue tissue slides, and publicly available multi‐omics datasets. Our results suggest that CAFs may impair the therapeutic efficacy of PD1 blockade in oral carcinogenesis by the remodeling of the extracellular matrix.
A unified framework and terminology for reproductive traits integral to understanding fish population productivity
Authors: Lowerre‐Barbieri Susan K. , Brown‐Peterson Nancy J. , Wyanski David M. , Moncrief‐Cox Heather E. , Kolmos Kevin J. , Menendez Hayden S. , Barnett Beverly K. , Friess Claudia 
Published: December 2023

AbstractObjectiveThis paper highlights the complexity of marine fish spawner–recruit systems and how they vary across species and ecosystems while providing a universal terminology and framework to evaluate fish reproduction. We emphasize the gonadal development important to assess maturity, fecundity, where and when fish spawn, and transition and sex assignment in protogynous species.MethodsWe review and compare reproductive traits in warmwater and coldwater fishes. Reproductive phases for both sexes and protogynous species are defined and histological micrographs presented. New methods are developed to assess maturity; spawning seasonality; peak spawning; and, for protogynous species, sex assignment.ResultProtogyny, extended spawning seasons, and indeterminate fecundity are more common in warmwater than coldwater systems. The following reproductive phases are defined as immature, transitional (sex change), early developing (the first stage of entrainment in the reproductive cycle), late developing (stages needed to complete maturational competence), spawning, regressing (spawning season termination), and regenerating (fish that are mature but outside of the spawning season). A method to assess the certainty of maturity assignment based on reproductive phase and the age and size range sampled is presented, as are best practices to estimate size and age at maturity. To remove the subjectivity from current methods to estimate spawning seasonality, we present a new quantitative method to identify the core spawning season and peak spawning months.ConclusionA species’ ability to adapt to fishing and climate change varies with their reproductive strategy. Improving our understanding of fish reproduction necessitates standardizing methodology and terminology.
Emerging potentials of Fe‐based nanomaterials for chiral sensing and imaging
Authors: Nwaji Njemuwa , Gwak Juyong , Nguyen My‐Chi , Nguyen Huu‐Quang , Kang Hyojin , Choi Youngeun , Kim Youngmi , Chen Hongxia , Lee Jaebeom 
Published: December 2023

AbstractFe‐based nanostructures have possessed promising properties that make it suitable for chiral sensing and imaging applications owing to their ultra‐small size, non‐toxicity, biocompatibility, excellent photostability, tunable fluorescence, and water solubility. This review summarizes the recent research progress in the field of Fe‐based nanostructures and places special emphases on their applications in chiral sensing and imaging. The synthetic strategies to prepare the targeted Fe‐based structures were also introduced. The chiral sensing and imaging applications of the nanostructures are discussed in details.
Novel de novo mutation in ZBTB20 in a Chinese Primrose syndrome family and a review of the literature
Authors: Li Jiayi , Zhang Chuan , Tian Xinyuan , Zhou Bingbo , Chen Xue , Wang Yupei , Hao Shengju , Hui Ling , Meng Zhaoyan 
Published: December 2023

AbstractBackgroundPrimrose syndrome is an autosomal dominant disorder characterized by craniofacial dysmorphism, mental retardation, developmental delay, progressive muscle atrophy and calcification of the earlobe due to a mutation in the ZBTB20.MethodWe reported a case of a Chinese boy with clinical symptoms resembling Primrose Syndrome, and performed genetic etiology analysis of the proband's family through Trio whole exome sequencing.ResultA novel missense variant c.1927T>A(p.F643I) in exon 14 of the ZBTB20 (NM_001348803) was identified in the proband. This is the first report case of primrose syndrome in China, and our case extends the variant spectrum of ZBTB20 and further strengthens the understanding of primrose syndrome.ConclusionHowever, there are no formal clinical guidelines for the management of this disease, and research on treatment and prognosis remains a challenge and focus in future.
Autosomal recessive intellectual disability caused by compound heterozygous variants of the EEF1D gene in a Chinese family
Authors: Zhang Jiamei , Liu Hongxing , Wang Mingmei , Xu Yiran , Zhu Dengna , Yang Fan 
Published: December 2023

AbstractBackgroundIntellectual disability is a prevalent neurodevelopmental disorder, with the majority of affected children exhibiting global developmental delay before the age of 5 years. In recent years, certain children have been found to carry homozygous variations of the EEF1D gene, leading to autosomal recessive intellectual disability. However, the pathogenicity of compound heterozygous variations in this gene remains largely unknown.MethodsTrio whole‐exome sequencing and copy number variation sequencing were done for the genetic etiological diagnosis of a 3‐year and 11‐month‐old Chinese boy who presented with brachycephaly, severe to profound global developmental delay, and hypotonia in the lower limbs.ResultsIn this case, compound heterozygous variants of the EEF1D gene were found in the child through trio whole‐exome sequencing; one was a splice variant (NM_032378.6:c.1905+1G>A) inherited from his father, and the other was a nonsense variant (NM_032378.6:c.676C>T) inherited from his mother. The nonsense variant leads to the production of a premature termination (p.Gln226*). These variations have the ability to explain the clinical phenotypes of the child.ConclusionsOur study expands the variation spectrum and provides compelling evidence for EEF1D as a candidate gene for autosomal recessive intellectual disability. However, due to the deficient number of reported cases, researchers need to further study EEF1D and supplement the clinical phenotypes and treatment measures.
PDSFit: PDS data analysis in the presence of orientation selectivity, g‐anisotropy, and exchange coupling
Authors: Abdullin Dinar , Rauh Corro Pablo , Hett Tobias , Schiemann Olav 
Published: December 2023

AbstractPulsed dipolar electron paramagnetic resonance spectroscopy (PDS), encompassing techniques such as pulsed electron–electron double resonance (PELDOR or DEER) and relaxation‐induced dipolar modulation enhancement (RIDME), is a valuable method in structural biology and materials science for obtaining nanometer‐scale distance distributions between electron spin centers. An important aspect of PDS is the extraction of distance distributions from the measured time traces. Most software used for this PDS data analysis relies on simplifying assumptions, such as assuming isotropic g‐factors of ~2 and neglecting orientation selectivity and exchange coupling. Here, the program PDSFit is introduced, which enables the analysis of PELDOR and RIDME time traces with or without orientation selectivity. It can be applied to spin systems consisting of up to two spin centers with anisotropic g‐factors and to spin systems with exchange coupling. It employs a model‐based fitting of the time traces using parametrized distance and angular distributions, and parametrized PDS background functions. The fitting procedure is followed by an error analysis for the optimized parameters of the distributions and backgrounds. Using five different experimental data sets published previously, the performance of PDSFit is tested and found to provide reliable solutions.