bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a ground intermediate transport from the helicopter landing site at a hospital on transport duration and patient safety
Authors: Hoechter Dominik J. , Schmalbach Bjarne , Schmidt Merve , Prueckner Stephan , Bayer Andreas 
Published: October 2023

Abstract
Background
Helicopter emergency medical service provides timely care and rapid transport of severely injured or critically ill patients. Due to constructional or regulatory provisions at some hospitals, a remote helicopter landing site necessitates an intermediate ground transport to the emergency department by ambulance which might lengthen patient transport time and comprises the risk of disconnection or loss of vascular access lines, breathing tubes or impairment of other relevant equipment during the loading processes. The aim of this study was to evaluate if a ground intermediate transport at the hospital site prolonged patient transport times and operating times or increases complication rates.

Methods
A retrospective analysis of all missions of a German air rescue service between 2012 and 2020 was conducted. Need of a ground transport at the accepting hospital, transfer time from the helipad to the hospital, overall patient transport time from the emergency location or the referring hospital to the accepting hospital and duration of the mission were analyzed. Several possible confounders such as type of mission, mechanical ventilation of the patient, use of syringe infusion pumps (SIPs), day- or nighttime were considered.

Results
Of a total of 179,003 missions (92,773 (51,8%) primary rescue missions, 10,001 (5,6%) polytrauma patients) 86,230 (48,2%) secondary transfers) an intermediate transport by ambulance occurred in 40,459 (22,6%) cases. While transfer times were prolonged from 6.3 to 8.8 min for primary rescue cases (p < 0.001) and from 9.2 to 13.5 min for interhospital retrieval missions (p < 0.001), the overall patient transport time was 14.8 versus 15.8 min (p < 0.001) in primary rescue and 23.5 versus 26.8 min (p < 0.001) in interhospital transfer. Linear regression analysis revealed a mean time difference of 3.91 min for mechanical ventilation of a patient (p < 0.001), 7.06 min for the use of SIPs (p < 0.001) and 2.73 min for an intermediate ambulance transfer (p < 0.001). There was no relevant difference of complication rates seen.

Conclusions
An intermediate ground transport from a remote helicopter landing site to the emergency department by ambulance at the receiving hospital had a minor impact on transportation times and complication rates.
Microinvasive pars plana vitrectomy combined with internal limiting membrane peeling versus anti-VEGF intravitreal injection for treatment-naïve diabetic macular edema (VVV-DME study): study protocol for a randomized controlled trial
Authors: Guo Haoxin , Li Wenbo , Nie Zetong , Zhang Xiang , Jiao Mingfei , Bai Siqiong , Duan Naxin , Li Xiaorong , Hu Bojie 
Published: October 2023

Abstract
Background
Diabetic macular edema (DME) is the main cause of vision loss in diabetic patients. Currently, anti-vascular endothelial growth factor (VEGF) intravitreal injection stands as the first-line therapy for DME. However, some patients exhibit insufficient response to anti-VEGF agents and often require multiple injections, imposing psychological and economic burdens. While microinvasive pars plana vitrectomy (PPV) has been shown to be safe and effective in treating refractory DME, scant research has explored its application to treatment-naïve DME. The purpose of this study is to determine whether early PPV combined with internal limiting membrane (ILM) peeling can lessen the therapeutic burden of DME patients, prevent vision loss, and maintain long-term stabilization of diabetic retinopathy.

Methods
This is a single-center, prospective, parallel-group, non-inferiority randomized controlled trial involving 102 DME participants. Participants will be randomly assigned to either the study group (PPV combined with ILM peeling) or the control group (conbercept intravitreal injection (IVC)) at a 1:1 ratio, with a scheduled follow-up at 12 months post-operation. Comparative analysis of results between the two groups will be conducted at months 1, 3, 6, and 12 after the intervention. The primary outcomes involve evaluating the changes in central subfield thickness (CST) and best corrected visual acuity (BCVA). The secondary outcomes include assessment of optical coherence tomography (OCT) and OCT angiography (OCTA) biomarkers, re-treatment and adverse events rates, diabetic retinopathy (DR) development, cost-effectiveness analysis, and vision-related quality of life (VRQL).

Discussion
Some patients do not respond well to anti-VEGF drugs and repeated intravitreal injections increase the treatment burden for patients. The VVV study aims to explore whether PPV combined with ILM peeling could become an initial treatment option for treatment-naïve DME patients.

Trial registration
ClinicalTrials.gov NCT05728476. Registered on 15 February 2023.
Point of care obstetric ultrasound training for midwives and nurses: implementation and experiences of trainees at a rural based hospital in Sub-saharan Africa: a qualitative study
Authors: Mubuuke Aloysius G. , Erem Geoffrey , Nassanga Rita , Kiguli-Malwadde Elsie 
Published: October 2023

Abstract
Background
Point of care ultrasound training has been successfully implemented in some settings. This has been done due to a shortage of radiology human resource gap especially in the rural areas of low-resource settings. The purpose of the study was to implement a point of care obstetric ultrasound training program for midwives and nurses and explore their experiences following the training at a rural based hospital in Uganda.

Methods
It was an exploratory qualitative study with some elements of implementation research design involving midwives and nurses that had undergone obstetric ultrasound training at Kiwoko hospital, a rural-based hospital in Uganda. Purposive sampling was used to select twenty-five midwives and nurses. These participants underwent a 6-weeks training in point of care obstetric ultrasound. Following the training, in-depth interviews were conducted to obtain the experiences of the participants.

Results
The training was conducted by qualified radiologists and sonographers and it involved both didactic sessions and rigorous practical and clinical demonstrations and eventually real-time scanning of the women. Three key themes emerged from the interviews: (1) Gaining important obstetric ultrasound skills, (2) Improving management of pregnant women and (3) Positive for task-shifting.

Conclusion
The point of care obstetric ultrasound training program was successfully implemented at Kiwoko Hospital. The trainees reported positive experiences from the training and while only conducted at one rural health facility, the overwhelmingly positive experience from trainees underscores the importance of point of care obstetric ultrasound in delivering imaging services.
Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
Authors: Ledesma-Corvi Sandra , Jornet-Plaza Jordi , García-Fuster M. Julia 
Published: October 2023

Abstract
Background
Ketamine has been recently approved to treat resistant depression; however preclinical studies showed sex differences in its efficacy. Sex steroids, such as estrogens and testosterone, both in the periphery and locally in the brain, are regarded as important modulators of these sex differences. Therefore, the present study evaluated how inhibiting the biosynthesis of estrogens with letrozole (an aromatase inhibitor) could affect the observed sex differences in ketamine's antidepressant-like-response.

Methods
We performed several consecutive studies in adult Sprague–Dawley rats to evaluate potential sex differences in the antidepressant-like effects of ketamine (5 mg/kg, 7 days, i.p.), letrozole (1 mg/kg, 8 days, i.p.) and their combination (letrozole pre-treatment 3 h before ketamine). Acute and repeated antidepressant-like responses were ascertained in a series of behavioral tests (forced-swim, novelty-suppressed feeding, two-bottle choice for sucrose preference).

Results
The main results proved clear sex differences in the antidepressant-like response induced by ketamine, which was observed following a repeated paradigm in adult male rats, but rendered inefficacious in female rats. Moreover, decreasing estrogens production with letrozole induced on itself an antidepressant-like response in female rats, while also increased ketamine's response in male rats (i.e., quicker response observed after only a single dose). Interestingly, both the antidepressant-like effects induced by ketamine in male rats or letrozole in female rats persisted over time up to 65 days post-treatment, suggesting long-term sex-directed benefits for these drugs.

Conclusions
The present results demonstrated a sex-specific role for aromatase inhibition with letrozole in the antidepressant-like response induced by ketamine in male rats. Moreover, letrozole itself presented as a potential antidepressant for females with persistent effects over time. Clearly, the production of estrogens is key in modulating, in a sex-specific manner, affective-like responses and thus deserve further studies.
Examining specific and non-specific symptoms of the best-fitting posttraumatic stress disorder model in conflict-exposed adolescents
Authors: Mordeno Imelu G. , Luzano Jelli Grace C. 
Published: October 2023

Abstract
Background
The 5th revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) construes PTSD symptoms into 4 clusters (intrusion, avoidance, negative alterations in cognitions and mood, alterations in arousal and reactivity; Model 1). However, recent literature has shown that this symptom structure does not best represent PTSD. Unfortunately, the findings of studies investigating the proposed alternative models are from consensus. Adding to the complexity of the issue of symptom-grouping models is the identification of specific and non-specific symptoms of PTSD. The present study aims to address these gaps by identifying the best-fitting PTSD model and subsequently examining what symptoms are considered specific and non-specific to PTSD in adolescent-survivors of armed political conflict and violence.

Methods
The study utilized a sample of 641 adolescent victim survivors. We conducted CFA analyses and compared nested models through the scaled χ2 difference test, while comparison of non-nested models was done using the Bayesian information criterion (BIC). The best-fitted model was used in the consequent analysis, where we statistically controlled for the effect of non-specific psychological distress on PTSD by comparing the factor loadings and factor correlations before and after accounting for distress using the Aroian z-test.

Results
The results provide support for the 7-factor hybrid model of PTSD over other proposed models for the current sample. Moreover, the data reveal that only 7 items could be construed as core symptoms, while the rest of the symptoms can be considered non-PTSD specific.

Conclusions
Overall, the findings provide support for the validity of the hybrid PTSD model among political conflict-exposed adolescents. The results also show that the DSM-5 PTSD has both specific and non-specific features in the present sample of conflict-exposed adolescents. This has potential implications for theory, practice, and treatment of the disorder.
Are algorithmically controlled gig workers deeply burned out? An empirical study on employee work engagement
Authors: Lang Jiao Jiao , Yang Li Feng , Cheng Chen , Cheng Xiang Yang , Chen Fei Yu 
Published: October 2023

Abstract
Background
With the emergence of the gig economy as a new economic form, the influence of algorithmic technology control on gig workers’ perceptions and engagement has become a topic of academic concern. This study explores the emotional impact of perceived algorithmic control on gig workers and how it affects their work engagement.

Methods
This study takes gig workers as the research object to build a structural equation model. Based on the background of gig economy and the Job Demands-Resources model, this paper constructs a mechanism model of the influence of perceived algorithmic control on the work engagement of gig workers. The research data in this paper are collected by questionnaire, and the research hypothesis is tested by the SEM structural model.

Results
The gig workers in this study believed that perceived algorithmic control positively affects employee work engagement. In addition, burnout was positively correlated with employee work engagement. Burnout played a partial mediating role in the relationship between perceived algorithmic control and employee work engagement. And flow experience played a moderating role through the indirect effect of burnout on employees’ work engagement.

Conclusion
Perceived algorithmic control causes burnout among gig workers, but strong algorithmic technology support provides them with rich work resources that can help them meet their work needs. That is, the gig workers may still demonstrate a high level of work engagement even if they experience burnout symptoms.
Smart bactericide based on reduced graphene oxide decorated with copper and zinc nanoparticles
Authors: Bytešníková Zuzana , Pečenka Jakub , Tekielska Dorota , Pekárková Jana , Ridošková Andrea , Bezdička Petr , Kiss Tomáš , Eichmeier Aleš , Adam Vojtěch , Richtera Lukáš 
Published: October 2023

AbstractGraphene oxide (GO) synthesised by modified Tour’s method was decorated with copper and zinc nanoparticles (NPs) and simultaneously reduced by sodium borohydride to obtain a nanocomposite of reduced GO with copper and zinc NPs (rGO–Cu–Zn). The nanocomposite rGO–Cu–Zn was characterised by transmission electron microscopy (TEM), energy dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The rGO–Cu–Zn was tested against Xanthomonas euvesicatoria (X. euvesicatoria), which attacks tomatoes and causes bacterial spots (BSs), and compared with the commercial product Champion 50 WG. Total bacterial growth inhibition was observed for the 1% rGO–Cu–Zn, whereas Champion 50 WG at the same concentration inhibited but did not eradicate all the bacterial colonies. To evaluate the negative effect of the rGO–Cu–Zn on the molecular level, the expression of the genes associated with the action of abiotic and biotic stress factors was analysed. Gene expression in the plants treated with 10% rGO–Cu–Zn did not exhibit a noticeable increase.
Graphical Abstract
Advancing the impact of plant biostimulants to sustainable agriculture through nanotechnologies
Authors: Magnabosco Pietro , Masi Antonio , Shukla Ravi , Bansal Vipul , Carletti Paolo 
Published: October 2023

AbstractNanomaterials and plant biostimulants are attracting significant attention for their potential applications in the agri-food sector. These efforts have mostly focused on the independent applicability of these two emerging fields to achieve improved agricultural outcomes. However, an even larger impact can be created if the emerging fields of nanotechnology and biostimulant technology are combined. This transdisciplinary review combines two diverse fields to highlight the potential role of nanotechnologies in advancing the impact of plant biostimulants for the sustainable production of high-quality food. The review first explains the key concepts of nanotechnology in a tutorial style to offer the agri-food research community an improved understanding of the potential of nanotechnology. The review then dives deeply into plant biostimulants which are substances or microorganisms or complex mixtures capable of improving plant nutrition and growth, directly influencing the aspects relevant to food quality, safety, and security. The review presents a convincing case that combining nanomaterials with biostimulants provides a promising sustainable answer against food insecurity for the near future. Sustainability is central to our discussions, which is exemplified by cases, such as the production of plant biostimulants from waste material, thus contributing to a circular economy. The review also identifies promising avenues to utilize nanotechnology for improving the value of biostimulants. Strategies such as nanoencapsulation are proposed to produce nano-biostimulants that could act synergistically to enhance food quality while offering a solution to the increasing challenge of food production while respecting the environment.
Graphical Abstract
Prognostic value of MRI volumetric parameters in non-small cell lung cancer patients after immune checkpoint inhibitor therapy: comparison with response assessment criteria
Authors: Roh Yun Hwa , Park Ji Eun , Kang Sora , Yoon Shinkyo , Kim Sang-We , Kim Ho Sung 
Published: October 2023

Abstract
Background
Accurate response parameters are important for patients with brain metastasis (BM) undergoing clinical trials using immunotherapy, considering poorly defined enhancement and variable responses. This study investigated MRI-based surrogate endpoints for patients with BM receiving immunotherapy.

Methods
Sixty-three non-small cell lung cancer patients with BM who received immune checkpoint inhibitors and underwent MRI were included. Tumor diameters were measured using a modification of the RECIST 1.1 (mRECIST), RANO-BM, and iRANO adjusted for BM (iRANO-BM). Tumor volumes were segmented on 3D contrast-enhanced T1-weighted imaging. Differences between the sum of the longest diameter (SLD) or total tumor volume at baseline and the corresponding measurement at time of the best overall response were calculated as “changes in SLDs” (for each set of criteria) and “change in volumetry,” respectively. Overall response rate (ORR), progressive disease (PD) assignment, and progression-free survival (PFS) were compared among the criteria. The prediction of overall survival (OS) was compared between diameter-based and volumetric change using Cox proportional hazards regression analysis.

Results
The mRECIST showed higher ORR (30.1% vs. both 17.5%) and PD assignment (34.9% vs. 25.4% [RANO-BM] and 19% [iRANO-BM]). The iRANO-BM had a longer median PFS (13.7 months) than RANO-BM (9.53 months) and mRECIST (7.73 months, P = 0.003). The change in volumetry was a significant predictor of OS (HR = 5.87, 95% CI: 1.46–23.64, P = 0.013). None of the changes in SLDs, as determined by RANO-BM or iRANO-BM, were significant predictors of OS, except for the mRECIST, which exhibited a weak association with OS.

Conclusion
Quantitative volume measurement may be an accurate surrogate endpoint for OS in patients with BM undergoing immunotherapy, especially considering the challenges of multiplicity and the heterogeneity of sub-centimeter size responses.
Developing an AI-based automated fashion design system: reflecting the work process of fashion designers
Authors: Choi Woojin , Jang Seyoon , Kim Ha Youn , Lee Yuri , Lee Sang-goo , Lee Hanbit , Park Sungchan 
Published: October 2023

AbstractWith the recent expansion of the applicability of artificial intelligence into the creative realm, attempts are being made to use AI (artificial intelligence) in the garment development system in various ways, both in academia and the fashion business. Several IT companies have developed and possess AI-based garment design technologies that utilize StyleGAN2 for image transformation. However, they are not widely utilized in the fashion business. Since fashion brands need to create numerous designs to launch new garment products for at least two seasons per year, the adoption of AI-based garment design generation technology can be one way to increase work efficiency. Therefore, this research aims to collect and analyze existing cases of AI-based garment design tools in order to identify the similarities and differences between the garment development processes of human designers and the existing AI-based garment design tools. Based on this analysis, the research aims to develop an AI-based garment development system that takes into consideration the garment development process of human designers, incorporating fashion domain knowledge.
Use of wild edible and nutraceutical plants in Raya-Azebo District of Tigray Region, northern Ethiopia
Authors: Giday Mirutse , Teklehaymanot Tilahun 
Published: October 2023

AbstractBackgroundAlthough there is a wide use of wild edible plants (WEPs) in Ethiopia, very little work has so far been done, particularly, in the Tigray Region, northern Ethiopia, to properly document the associated knowledge. The purpose of this study was, therefore, to document knowledge and analyze data related to the use of wild edible and nutraceutical plants in Raya-Azebo District of Tigray Region. The district was prioritized for the study to avoid the further loss of local knowledge and discontinuation of the associated practices because of the depletion of wild edible plants in the area mainly due to agricultural expansion and largely by private investors.MethodsA cross-sectional ethnobotanical study was carried out in the study District to collect data through individual interviews held with purposively selected informants, observation, market surveys, and ranking exercises. Descriptive and inferential statistical methods were employed to analyze and summarize the data using Statistical Package for Social Sciences (SPSS) version 16.ResultsThe study documented 59 WEPs, the majority of which (57.63%) were sought for their fruits. Most of the WEPs (49 species) were consumed in the autumn, locally called qewei, which includes the months of September, October, and November.Ziziphus spina-christiL. Desf.,Balanites aegyptiaca(L.) Del. andOpuntia ficus-indica(L.) Miller were the most preferred WEPs. Both interviews and local market surveys revealed the marketability ofOpuntia ficus-indica, Ziziphus spina-christi, Ficus vastaForssk., Ficus surForssk.,andBalanites aegyptiaca. Of the total WEPs, 21 were reported to have medicinal (nutraceutical) values, of whichBalanites aegyptiacaandAcacia etbaicascored the highest rank order priority (ROP) values for their uses to treat anthrax and skin infections, respectively.ConclusionsThe current investigation demonstrated the wide use of WEPs in the district. In future nutritional composition analysis studies, priority should be given to the most popular WEPs, and nutraceutical plants with the highest ROP values.