bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solid Electrolyte Bimodal Grain Structures for Improved Cycling Performance
Authors: Jia Zhanhui , Shen Hao , Kou Jiawei , Zhang Tianyi , Wang Zhen , Tang Wei , Doeff Marca , Chiang Ching‐Yu , Chen Kai 
Published: January 2024

AbstractThe application of solid‐state electrolytes in Li batteries is hampered by the occurrence of Li‐dendrite‐caused short circuits. To avoid cell failure, the electrolytes can only be stressed with rather low current densities, severely restricting their performance. As grain size and pore distributions significantly affect dendrite growth in ceramic electrolytes such as Li7La3Zr2O12 and its variants; here, a “detour and buffer” strategy to bring the superiority of both coarse and fine grains into play, is proposed. To validate the mechanism, a coarse/fine bimodal grain microstructure is obtained by seeding unpulverized large particles in the green body. The rearrangement of coarse grains and fine pores is fine‐tuned by changing the ratio of pulverized and unpulverized powders. The optimized bimodal microstructure, obtained when the two powders are equally mixed, allows, without extra interface decoration, cycling for over 2000 h as the current density is increased from 1.0 mA·cm−2, and gradually, up to 2.0 mA·cm−2. The “detour and buffer” effects are confirmed from postmortem analysis. The complex grain boundaries formed by fine grains discourage the direct infiltration of Li. Simultaneously, the coarse grains further increase the tortuosity of the Li path. This study sheds light on the microstructure optimization for the polycrystalline solid‐state electrolytes.
Soft‐Hard Janus Nanoparticles Triggered Hierarchical Conductors with Large Stretchability, High Sensitivity, and Superior Mechanical Properties
Authors: He Hailing , Yang Tiantian , Liu Tianlin , Gao Yeqi , Zhang Zhaoyuan , Yang Zhenzhong , Liang Fuxin 
Published: January 2024

AbstractThere is a long‐standing conflict between the large stretchability and high sensitivity for strain sensors, a strategy of decoupling the mechanical/electrical module by constructing the hierarchical conductor has been developed in this study. The hierarchical conductor, consisting of a mechanically stretchable layer, a conductive network layer, and a strongly bonded interface, can be produced in a simple one‐step process with the aid of soft‐hard Janus nanoparticles (JNPs). The introduction of JNPs in the stretchable layer can evenly distribute stress and dissipate energy due to forming the rigid‐flexible homogeneous networks. Specifically, JNPs can drive graphene nanosheets (GNS) to fold or curl, creating the unique JNPs‐GNS building block that can further construct the conductive network. Due to its excellent deformability to hinder crack propagation, the flexible conductive network could be stretched continuously and the local conductive pathways could be reconstructed. Consequently, the hierarchical conductor could detect both subtle strain of 0−2% and large strain of up to 370%, with a gauge factor (GF) from 66.37 to 971.70, demonstrating outstanding stretchability and sensitivity. And it also owns large tensile strength (5.28 MPa) and high deformation stability. This hierarchical design will give graphene‐based sensors a major boost in emerging applications.
Injectable Microgels with Hybrid Exosomes of Chondrocyte‐Targeted FGF18 Gene‐Editing and Self‐Renewable Lubrication for Osteoarthritis Therapy
Authors: Chen Manyu , Lu Yan , Liu Yuhan , Liu Quanying , Deng Siyan , Liu Yuan , Cui Xiaolin , Liang Jie , Zhang Xingdong , Fan Yujiang , Wang Qiguang 
Published: January 2024

AbstractAbnormal silencing of fibroblast growth factor (FGF) signaling significantly contributes to joint dysplasia and osteoarthritis (OA); However, the clinical translation of FGF18‐based protein drugs is hindered by their short half‐life, low delivery efficiency and the need for repeated articular injections. This study proposes a CRISPR/Cas9‐based approach to effectively activate the FGF18 gene of OA chondrocytes at the genome level in vivo, using chondrocyte‐affinity peptide (CAP) incorporated hybrid exosomes (CAP/FGF18‐hyEXO) loaded with an FGF18‐targeted gene‐editing tool. Furthermore, CAP/FGF18‐hyEXO are encapsulated in methacrylic anhydride‐modified hyaluronic (HAMA) hydrogel microspheres via microfluidics and photopolymerization to create an injectable microgel system (CAP/FGF18‐hyEXO@HMs) with self‐renewable hydration layers to provide persistent lubrication in response to frictional wear. Together, the injectable CAP/FGF18‐hyEXO@HMs, combined with in vivo FGF18 gene editing and continuous lubrication, have demonstrated their capacity to synergistically promote cartilage regeneration, decrease inflammation, and prevent ECM degradation both in vitro and in vivo, holding great potential for clinical translation.
Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy
Authors: Tan Fei , Xu Maoxiang , Li Xuran , Wang Zhao , Li Jiaojiao , Shahzad Khawar Ali 
Published: January 2024

AbstractStem cell‐derived small extracellular vesicles (sEVs) have shown tremendous potential in regenerative medicine in recent years. These sEVs exert multiple therapeutic effects comparable or superior to their parental stem cells while avoiding the limitations of stem cell‐based therapy. The two routine modalities of sEV administration are systemic injection and local delivery. Various biomaterials are developed to assist their local delivery to improve the targeting of organs, minimize nonspecific accumulation in vital organs, and ensure the protection and release of sEVs. This comprehensive, up‐to‐date, specialty‐specific, disease‐oriented, and preclinical review is presented to expound on the surgical application and potential of stem cell‐derived sEVs. The local delivery of stem cell‐derived sEVscan treat numerous diseases encountered in orthopedic surgery, neurosurgery, plastic surgery, cardiothoracic surgery, general surgery, urology, otorhinolaryngology, ophthalmology, obstetrics and gynecology, and dental surgery. In addition, the biomaterials utilized encompass a wide range of sources (e.g., natural, synthetic, and hybrid polymers), format (e.g., scaffold, patch, spray, microneedle), and responsiveness (e.g., temperature, pH, and protein), which enables customized sEV therapy tailored to specific diseases. This review demonstrates biomaterial‐facilitated local delivery of stem cell‐derived sEVs as a viable alternative or even a superior option to systemic sEV therapy.
Lead exposure and its relationship with fecal cortisol levels in black howler monkeys (Alouatta pigra)
Authors: Alvarez‐Velazquez María Fernanda , González‐Jáuregui Mauricio , Miranda Sergio Albino , Rosano‐Ortega Genoveva , Chapman Colin A. , Serio‐Silva Juan Carlos 
Published: January 2024

AbstractEfficiently detecting early environmental threats to wildlife is vital for conservation. Beyond obvious dangers like habitat loss or deforestation, our study focuses on one of the most hazardous toxic metals for wildlife: lead (Pb). Pb is a widespread, cumulative, and insidious environmental pollutant that can trigger a wide range of physiological, biochemical, and behavioral disorders. In fact, Pb can cause permanent dysfunction of the major stress system, the hypothalamic pituitary adrenal (HPA) axis. We analyzed Pb and cortisol concentrations in fecal samples from Alouatta pigra in southern Mexico. Fecal samples were collected across six sites categorized as free‐ranging (n = 65; conserved and disturbed) and from captive animals (n = 58). Additionally, we collected soil samples (n = 35). We found that Pb was present in 28% of fecal samples and 83% of soil samples. There was a positive relation between fecal and soil Pb levels, and fecal Pb concentration was negatively associated with cortisol levels. However, the claim of Pb being a direct interference with HPA axis requires further investigation. Given our findings, assessing wildlife exposure can be a valuable tool for understanding potential Pb exposure levels in the environment and its possible implications for human health. It can also serve as an early warning system of these consequences.
Cyano‐Functionalized Pyrazine: A Structurally Simple and Easily Accessible Electron‐Deficient Building Block for n‐Type Organic Thermoelectric Polymers
Authors: Tu Lijun , Wang Junwei , Wu Ziang , Li Jianfeng , Yang Wanli , Liu Bin , Wu Siqi , Xia Xiaomin , Wang Yimei , Woo Han Young , Shi Yongqiang 
Published: January 2024

AbstractDeveloping low‐cost and high‐performance n‐type polymer semiconductors is essential to accelerate the application of organic thermoelectrics (OTEs). To achieve this objective, it is critical to design strong electron‐deficient building blocks with simple structure and easy synthesis, which are essential for the development of n‐type polymer semiconductors. Herein, we synthesized two cyano‐functionalized highly electron‐deficient building blocks, namely 3,6‐dibromopyrazine‐2‐carbonitrile (CNPz) and 3,6‐Dibromopyrazine‐2,5‐dicarbonitrile (DCNPz), which feature simple structures and facile synthesis. CNPz and DCNPz can be obtained via only one‐step reaction and three‐step reactions from cheap raw materials, respectively. Based on CNPz and DCNPz, two acceptor–acceptor (A–A) polymers, P(DPP‐CNPz) and P(DPP‐DCNPz) are successfully developed, featuring deep‐positioned lowest unoccupied molecular orbital (LUMO) energy levels, which are beneficial to n‐type organic thin‐film transistors (OTFTs) and OTEs performance. An optimal unipolar electron mobility of 0.85 and 1.85 cm2 V−1 s−1 is obtained for P(DPP‐CNPz) and P(DPP‐DCNPz), respectively. When doped with N‐DMBI, P(DPP‐CNPz) and P(DPP‐DCNPz) show high n‐type electrical conductivities/power factors of 25.3 S cm−1/41.4 μW m−1 K−2, and 33.9 S cm−1/30.4 μW m−1 K−2, respectively. Hence, the cyano‐functionalized pyrazine CNPz and DCNPz represent a new class of structurally simple, low‐cost and readily accessible electron‐deficient building block for constructing n‐type polymer semiconductors.
Optical properties of Cu, Ag, and Au nanoparticles with different sizes and shapes
Authors: Michos Fotios I. , Chronis Alexandros G. , Garoufalis Christos S. , Sigalas Michael M. 
Published: January 2024

AbstractThe absorption spectra of various sizes of nanoparticles of copper (Cu), silver (Ag), and gold (Au) are theoretically investigated. The density functional theory (DFT), time‐dependent DFT (TDDFT), and real‐time TDDFT are used to demonstrate how size and shape affect their optical properties and how these are evolved as the number of atoms increases. For this reason, the focus was turned on almost spherical nanoparticles cut out from the corresponding crystal structure (called 0D), elongated ones (1D), and flattened ones (2D). The nature of the observed absorption peaks is further analyzed with the help of transition contribution maps and induced density plots which help us identify the emergence of probable plasmonic resonances as the size of the nanoparticles increases.
Research progress of oxygen redox in sodium‐layered oxides
Authors: Gu Mubao , Xu Junling , Shi Xiaoyan , Shao Lianyi , Sun Zhipeng 
Published: January 2024

AbstractSodium‐ion batteries are emerging as promising alternative energy sources compared to lithium‐ion batteries, due to the abundant sodium resources in Earth's crust and their low cost. Nevertheless, the larger ionic radius of sodium ions leads to minor energy density in sodium‐layered oxide cathodes. To address this, anionic redox has attracted significant attention as it provides additional capacity beyond cationic redox. In this comprehensive review, the history and fundamental mechanisms of anionic redox are systematically summarized, and the recent advancements in sodium‐layered oxides with anionic redox is categorized and discussed according to deficient sodium‐layered oxides, stoichiometric sodium‐layered oxides, and sodium‐rich layered oxides. Finally, several prospects and challenges for anionic redox‐layered oxide cathodes have also been proposed. This review sheds light on the potential trajectory of sodium‐ion battery technology and highlights the pathways to harness the full capabilities of anionic redox for energy storage applications.
Neuroinflammation and Acetylcholinesterase Inhibitory Potentials of a Spiroketal‐Enol Ether Polyyne Isolated from Artemisia pallens Wall. ex DC
Authors: Singh Swati , Bhatt Divya , Kumar Singh Munmun , Bisht Surbhi , Sundaresan Velusamy , Chandra Padalia Rajendra , Umrao Bawankule Dnyaneshwar , Swaroop Verma Ram 
Published: January 2024

AbstractArtemisia pallens Wall. ex DC (Asteraceae) is cultivated for the production of high‐value essential oil from its aerial biomass. In this study, the chemical composition of the root (crop‐residue) essential oil was investigated for the first time, using column‐chromatography, GC−FID, GC−MS, LC−QTOF, and NMR techniques, which led to the identification of twenty constituents, with isolation of (E)‐2‐(2′,4′‐hexadiynylidene)‐1,6‐dioxaspiro [4.5]dec‐3‐ene (D6). The D6 was evaluated in vitro for neuroinflammation and acetylcholinesterase inhibitory potential. It showed inhibition of neuroinflammation in a concentration‐dependent manner with significant inhibition of pro‐inflammatory cytokines (TNF‐α and IL‐6) in LPS‐stimulated BV2 microglial cells. D6 did not have any significant effect on the viability of the cells at the therapeutic concentrations. D6 also has shown acetylcholinesterase inhibitory potential (51.90±1.19 %) at the concentration of log 106 nM. The results showed that D6 has a potential role in the resolution of neuroinflammation, and its acetylcholinesterase inhibitory potential directs further investigation of its role in the management of Alzheimer's disease‐related pathogenesis.
HPLC‐MS/MS Profiles, Antioxidant, Neuroprotective, Antidiabetic and Skin Protective Effects of Different Extracts of Vicia peregrina L. Collected from the Eastern Region of Turkey
Authors: Yagi Sakina , Ulusan Musa Denizhan , Sinan Kouadio Ibrahime , Caprioli Giovanni , Mustafa Ahmed M. , Angeloni Simone , Ahıskalı Mihriban , Zengin Gokhan 
Published: January 2024

AbstractMany Vicia species (Fabaceae) were proven to possess bioactive compounds with potential health beneficial properties. The present study was designed to determine the phenolic constituents, antioxidant and enzyme inhibition activities of aerial parts and seed of V. peregrina. Hexane, ethyl acetate and methanol extracts were prepared by maceration and aqueous extract by infusion. The chemical compositions of the extracts were determined using HPLC‐MS/MS technology. The antioxidant activities were examined using various assays including free radical scavenging (ABTS and DPPH), reducing ability (CUPRAC and FRAP), metal chelation, and phosphomolybdenum. The enzyme inhibitory effects were investigated against cholinesterase, tyrosinase, amylase and glucosidase. The highest total phenolics and flavonoids contents were recorded in the methanol extracts of the seed (45.42 mg GAE/g) and aerial parts (40.33 mg RE/g) respectively. The aerial parts were characterized by higher accumulation of chlorogenic acid (9893.86 μg g−1), isoquercitrin (9400.33 μg g−1), delphindin 3,5 diglucoside (9113.28 μg g−1), hyperoside (6337.09 μg g−1), rutin (3489.83 μg g−1) and kaempferol‐3‐glucoside (2872.84 μg g−1). Generally, the methanol and aqueous extracts of the two studied parts exerted the best antioxidant activity with highest anti‐DPPH (61.99 mg TE/g), anti‐ABTS (101.80 mg TE/g) and Cu++ (16169 mg TE/g) and Fe+++ (172,36 mg TE/g) reducing capacity were recorded from the seed methanol extract. Methanol extract of the seed showed the best anti‐tyrosinase activity (75.86 mg KAE/g). These results indicated that V. peregrina is rich with bioactive phenolics suggesting their use in different health promoting applications.
SGLT2 inhibitors and AMPK: The road to cellular housekeeping?
Authors: Safaie Nasser , Masoumi Shahab , Alizadeh Shaban , Mirzajanzadeh Pourya , Nejabati Hamid Reza , Hajiabbasi Mobasher , Alivirdiloo Vahid , Basmenji Neda Chobdari , Derakhshi Radvar Aysan , Majidi Ziba , Faridvand Yousef 
Published: January 2024

AbstractSodium‐glucose co‐transporter‐2 (SGLT2) inhibitors, known as Gliflozins, are a class of Glucose‐lowering drugs in adults with type 2 diabetes (T2D) that induce glucosuria by blocking SGLT2 co‐transporters in the proximal tubules. Several lines of evidence suggest that SGLT2 inhibitors regulate multiple mechanisms associated with the regulation of varying cellular pathways. The 5′‐adenosine monophosphate‐activated protein kinase (AMPK) pathway plays an important role in metabolic homeostasis by influencing cellular processes. Recently, it has been shown that SGLT2 inhibitors can affect the AMPK pathway in differing physiological and pathological ways, resulting in kidney, intestinal, cardiovascular, and liver protective effects. Additionally, they have therapeutic effects on nonalcoholic fatty liver disease and diabetes mellitus‐associated complications. In this review, we summarize the results of studies of AMPK‐associated therapeutic effects of SGLT2 inhibitors in different organelle functions.
Menu labeling and portion size control to improve the out‐of‐home food environment: A scoping review
Authors: Jeyashree Kathiresan , Abdulkader Rizwan S. , Haridoss Madhumitha , Govindaraju Ranjithkumar , Brand Amanda , Visser Marianne , Gordon Sarah , Tiwari Hemant , Sumitha T. S. , Chandran Krupa , Mabetha Denny , Durão Solange 
Published: January 2024

AbstractBackgroundMenu labeling and portion size control interventions may be effective strategies to mitigate the health risks posed by the out‐of‐home food environment. We conducted this scoping review to map the body of evidence (BoE) addressing the effects of menu labeling and portion size control interventions in the out‐of‐home food environment and to summarize the research gaps in this evidence base.MethodsWe searched PubMed, Embase, Epistemonikos, and PROSPERO in phase 1 for systematic reviews (SRs) and PubMed and Embase in phase 2 for primary studies in areas with insufficient SR evidence. We used a comprehensive search strategy without any restrictions on publication date, language, study population characteristics or outcomes. We screened all titles independently and in duplicate. We mapped the number of systematic reviews providing evidence per intervention‐setting combination in a matrix. The gaps in the matrix informed the searches for primary studies in phase 2. For the included SR protocols and primary studies, we charted the population, intervention, comparator, outcome, period, and study design to facilitate their evaluation and inclusion in future evidence syntheses.ResultsWe included 69 completed SRs; 37 on menu labeling, 9 on portion size control, and 23 on both. The types of menu labeling interventions studied were quantitative nutrient information (74%), interpretational guidance (48%), or contextual guidance (13%). Most reviews were from the United States, United Kingdom, and Canada. Most SRs included studies in establishments like cafeterias (51%) or restaurants (39%) and measured change in the quantity of food offered/ordered/consumed (96%). Phase 2 search yielded 24 primary studies; 16 experimental, 6 quasi‐experimental, and 2 observational studies.ConclusionThe BoE on the effectiveness of menu labeling and portion size control is predominantly from the developed world, on nutrient information labeling and reporting impact on consumer food choice. There is a need for studies in the online environment and reporting distal health outcomes.
Human capital and pandemic‐related stimulus usage
Authors: Pandey Sabina , Guillemette Michael A. , Asebedo Sarah D. 
Published: January 2024

AbstractUsing nationally representative data from the 2021 National Financial Capability Study (NFCS), this study investigates the association between human capital, as proxied through education and objective financial knowledge, and stimulus payment usage for spending, debt repayment, savings, and investments during the COVID‐19 pandemic. The results from a sample of 23,344 observations suggest that human capital relates to differences in how people used their COVID‐19 stimulus payments. In particular, the study found that human capital is associated positively with using stimulus payments to add to savings or invest in the stock market.
Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends
Authors: Davodabadi Fatemeh , Farasati Far Bahareh , Sargazi Saman , Fatemeh Sajjadi Seyedeh , Fathi‐karkan Sonia , Mirinejad Shekoufeh , Ghotekar Suresh , Sargazi Sara , Rahman Mohammed M. 
Published: January 2024

AbstractThis review article spotlights the burgeoning potential of using nanotherapeutic strategies to target long non‐coding RNAs (lncRNAs) in cancer cells. This updated discourse underlines the prominent role of lncRNAs in instigating cancer, facilitating its progression, and metastasis, validating lncRNAs′ potential for being effective diagnostic biomarkers and therapeutic targets. The manuscript offers an in‐depth examination of different strategies presently employed to modulate lncRNA expression and function for therapeutic purposes. Among these strategies, Antisense Oligonucleotides (ASOs), RNA interference (RNAi) technologies, and the innovative clustered regularly interspaced short palindromic repeats (CRISPR)‐based gene editing tools garner noteworthy mention. A significant section of the review is dedicated to nanocarriers and their crucial role in drug delivery. These nanocarriers′ efficiency in targeting lncRNAs in varied types of cancers is elaborated upon, validating the importance of targeted therapy. The manuscript culminates by reaffirming the promising prospects of targeting lncRNAs to enhance the accuracy of cancer diagnosis and improve treatment efficacy. Consequently, new paths are opened to more research and innovation in employing nanotherapeutic approaches against lncRNAs in cancer cells. Thus, this comprehensive manuscript serves as a valuable resource that underscores the vital role of lncRNAs and the various nano‐strategies for targeting them in cancer treatment. Future research should also focus on unraveling the complex regulatory networks involving lncRNAs and identifying fundamental functional interactions to refine therapeutic strategies targeting lncRNAs in cancer.
Estimate of the C−Cl photoionization cross section and absolute photoionization cross sections of chlorinated organic compounds
Authors: Chen Yilan Lori , Taatjes Craig A. , Meloni Giovanni 
Published: January 2024

AbstractChlorinated organic compounds are prominently used for industrial production, but their vapors and emission byproducts can cause detrimental effects to human health and the environment. To accurately quantify organochlorine compounds, the absolute photoionization cross section of tetrachloroethylene, chlorobenzene, 1,2‐dichlorobenzene, and chloroacetone are measured using multiplexed synchrotron photoionization mass spectrometry at the Advanced Light Source at Lawrence Berkeley National Laboratory. These measurements allow for the estimation of the C−Cl photoionization cross section, increasing quantification accuracy of chlorinated emissions for kinetic modeling and pollutant mitigation. CBS‐QB3 calculations of adiabatic ionization energies and thermochemical appearance energies are also presented and agree well with the experimental results.