bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative analysis of the dominant external factors influencing elite speed Skaters' performance using BP neural network
Authors: Yang Zhenlong , Ke Peng , Zhang Yiming , Du Feng , Hong Ping 
Published: February 2024

IntroductionSpeed skating, being a popular winter sport, imposes significant demands on elite skaters, necessitating their effective assessment and adaptation to diverse environmental factors to achieve optimal race performance.ObjectiveThe aim of this study was to conduct a thorough analysis of the predominant external factors influencing the performance of elite speed skaters.MethodsA total of 403 races, encompassing various race distances and spanning from the 2013 to the 2022 seasons, were examined for eight high-caliber speed skaters from the Chinese national team. We developed a comprehensive analytical framework utilizing an advanced back-propagation (BP) neural neural network model to assess three key factors on race performance: ice rink altitude, ice surface temperature, and race frequency.ResultsOur research indicated that the performance of all skaters improves with higher rink altitudes, particularly in races of 1,000 m and beyond. The ice surface temperature can either enhance or impaire performance and varies in its influences based on skaters' technical characteristics, which had a perceptible or even important influence on races of 1,500 m and beyond, and a negligible influence in the 500 m and 1,000 m races. An increase in race frequency generally contributed to better performance. The influence was relatively minor in the 500 m race, important in the 3,000 m race, and varied among individuals in the 1,000 m and 1,500 m races.ConclusionThe study results offer crucial guidelines for speed skaters and coaches, aiding in the optimization of their training and competition strategies, ultimately leading to improved competitive performance levels.
Global research hotspots and trends on robotic surgery in obstetrics and gynecology: a bibliometric analysis based on VOSviewer
Authors: Xiao Peichen , Li Lu , Qu Jinfeng , Wang Guangxin 
Published: February 2024

ObjectiveOver the last two decades, the quantity of papers published in relation to robotic surgery in obstetrics and gynecology has continued to grow globally. However, no bibliometric analysis based on VOSviewer has been performed to evaluate the past and present of global research in the field. In this study, we aimed to analyze the bibliometric characteristics of papers on robotic surgery in obstetrics and gynecology to reveal research hotspots and trends in this field.MethodsThe Web of Science Core Collection was searched for scientific papers on robotic surgery in obstetrics and gynecology published between January 1, 1998 and December 31, 2023. Bibliometric metadata of each selected paper was extracted for analysis. The results were visualized by VOSviewer (version 1.6.18).ResultsA total of 1,430 papers met the inclusion criteria. The United States had the highest total link strengths and contributed the most papers (n = 793). The Mayo Clinic produced the largest number of papers (n = 85), and Professor Pedro T Ramirez contributed the most papers (n = 36). The number of citations ranged from 0 to 295 with a total sum of 29,103. The Journal of Minimally Invasive Gynecology published the most relevant papers (n = 252). Keywords were classified into six clusters based on co-occurrence data, of which cluster 1, cluster 4 and cluster 6 had more main keywords with the largest average publication year.ConclusionsThis is the first VOSviewer-based bibliometric analysis of robotic surgery research in obstetrics and gynecology. The United States was the leading country, and the Journal of Minimally Invasive Gynecology was the most productive journal in the field. Scientists and institutions from around the world should push their boundaries to bring about deep collaboration. The main research topic has always been the use of robotic surgery in the treatment of gynecologic malignancies. More randomized controlled trials need to be conducted to compare surgical outcomes of robotic surgery with other surgical approaches. Robotic sacrocolpopexy for pelvic organ prolapse has become a new research hotspot, and robotic surgery for sentinel lymph node detection in gynecologic malignancies are more potential directions for future research.
Use of quantitative mass spectrometry-based proteomics and ELISA to compare the alpha 2 macroglobulin concentration in equine blood-based products processed by three different orthobiologic devices
Authors: Ortved Kyla F. , Alward Larry , Cowles Bobby , Linardi Renata , Barot Dhvani , Usimaki Alex , Fedie Joseph R. , Amodie Deb , Goodrich Laurie R. 
Published: February 2024

IntroductionAlpha 2 macroglobulin (A2M), a multi-functional protein in the plasma protease inhibitor class, regulates proinflammatory cytokines and the clearance of chondrodestructive enzymes in cases of joint injury and osteoarthritis (OA). The purpose of this study was to compare A2M concentrations in equine plasma samples processed by three commercial devices developed for stall-side regenerative joint therapy.MethodsPlasma samples were obtained from healthy adult horses (N = 13). Mass spectrometry analysis was used to determine the concentration of protein analytes in each sample. Selected reaction monitoring measured a specific A2M peptide as a surrogate of the whole A2M protein. A2M concentrations produced by each test device were compared for two sample types: a pre-concentrate or platelet-poor (PP) component and a final component for use in the horse.ResultsThere was no significant difference (p &gt; 0.05) in the geometric mean (GM) concentration of A2M in the final concentration samples produced by the Alpha2EQ® device (N horses = 13) and the single-centrifugation PP samples produced by the Pro-Stride® APS (autologous protein solution) device (N = 13) and the Restigen® PRP (platelet-rich plasma) device (N = 11). When A2M content in final concentration samples produced by each device was compared, the Pro-Stride APS and Restigen PRP samples had significantly greater GM A2M content (p &lt; 0.0001) compared to the Alpha2EQ samples, and the Pro-Stride APS final concentration samples had significantly greater GM A2M concentration (p &lt; 0.0001) versus that for the Restigen PRP final samples.DiscussionThis comparison demonstrated that the volume and A2M concentration of an Alpha2EQ final concentrate are no different than the volume and concentration of A2M in the PP from Pro-Stride or Restigen devices.
Reactivity of the Ethenium Cation (C2H5+) with Ethyne (C2H2): A Combined Experimental and Theoretical Study
Authors: Richardson Vincent , Polášek Miroslav , Romanzin Claire , Tosi Paolo , Thissen Roland , Alcaraz Christian , Žabka Ján , Ascenzi Daniela 
Published: February 2024

The gas-phase reaction between the ethyl cation (C2H5+) and ethyne (C2H2) is re-investigated by measuring absolute reactive cross sections (CSs) and branching ratios (BRs) as a function of collision energy, in the thermal and hyperthermal energy range, via tandem-guided ion beam mass spectrometry under single collision conditions. Dissociative photoionization of C2H5Br using tuneable VUV radiation in the range 10.5–14.0 eV is employed to generate C2H5+, which has also allowed us to explore the impact of increasing (vibrational) excitation on the reactivity. Reactivity experiments are complemented by theoretical calculations, at the G4 level of theory, of the relative energies and structures of the most relevant stationary points on the reactive potential energy hypersurface (PES) and by mass-analyzed ion kinetic energy (MIKE) spectrometry experiments to probe the metastable decomposition from the [C4H7]+ PES and elucidate the underlying reaction mechanisms. Two main product channels have been identified at a centre-of-mass collision energy of ∼0.1 eV: (a) C3H3++CH4, with BR = 0.76±0.05 and (b) C4H5++H2, with BR = 0.22±0.02. A third channel giving C2H3+ in association with C2H4 is shown to emerge at both high internal excitation of C2H5+ and high collision energies. From CS measurements, energy-dependent total rate constants in the range 4.3×10−11−5.2×10−10 cm3·molecule−1·s−1 have been obtained. Theoretical calculations indicate that both channels stem from a common covalently bound intermediate, CH3CH2CHCH+, from which barrierless and exothermic pathways exist for the production of both cyclic c−C3H3+ and linear H2CCCH+ isomers of the main product channel. For the minor C4H5+ product, two isomers are energetically accessible: the three-member cyclic isomer c−C3H2(CH3)+ and the higher energy linear structure CH2CHCCH2+, but their formation requires multiple isomerization steps and passages via transition states lying only 0.11 eV below the reagents’ energy, thus explaining the smaller BR. Results have implications for the modeling of hydrocarbon chemistry in the interstellar medium and the atmospheres of planets and satellites as well as in laboratory plasmas (e.g., plasma-enhanced chemical vapor deposition of carbon nanotubes and diamond-like carbon films).
Factors associated with parental self-medication for common childhood illnesses during the COVID-19 pandemic: a single centre study
Authors: FCPS Farhan Saeed DCH , FCPS, CHPE Shireen Qassim Bham, DCH, , MRCPCH Mohammed Iqbal MBBS, , Sharif Umer Hayat Ahmed 
Published: February 2024

Background & Objective: People's interest regarding self-medication increased during the first half of 2020, when the COVID-19 was proclaimed a pandemic, although it has always persisted due to multiple factors. We aimed to identify the factors associated with the use of parental self-medication for their child’s illness during the COVID-19 pandemic.
Methodology: A cross-sectional descriptive study was conducted at the pediatrics department at Darul Sehat Hospital, Karachi. An interviewer-administered questionnaire was used. We included 275 parents visiting the outpatient clinics with their children of ages 1 to 12 y. Chi-square test of independence was used to check the association of self-medication with studied factors. P-values less than 0.05 were considered significant.
Results: Out of 275 parents, 85% were practicing self-medication. 60.3% children suffered from some illness. Parents sought medical advice from pharmacists in 65% of cases, and allopathic drugs were preferred in 64% of cases. 70% of the patients used medicine until recovered, while 41.9% had to seek medical advice. Frequent symptoms obsereved and treated with self-medication were headaches 19.2% and fever 18.8%.
Conclusion: Parental self-medication for common childhood illnesses was substantially more prevalent during the COVID-19 pandemic. Allopathic medicines were preferred choice of parents while pharmacists were commonly consulted for information regarding drugs.
Abbreviations: OTC: Over-the-counter;
Key words: Self-medication; Side effects; Pharmacists: Medications; Antipyretics
Citation: Saeed F, Bham SQ, Mohammed Iqbal M, Sharif UHA. Factors associated with parental self-medication for common childhood illnesses during the COVID-19 pandemic: a single centre study. Anaesth. pain intensive care 2023;27(3):405−412.
DOI: 10.35975/apic.v27i3.2097
Received: December 26, 2022; Reviewed: January 15, 2023; Accepted: April 13, 2023
Early postoperative recovery quality assessment tools for day surgery patients
Authors: Nibaruta Janvier , Xingjiao Lv , Xiaoxia Han , Xiaoyu Hou , Xuefen Cao , Yufang Leng 
Published: February 2024

From the patient's perspective, medical personnel must assess the patients’ recovery reliability in case of day surgery patients. Rather than focusing solely on clinical recovery indicators, it should consider the patient's pain, physiological, psychological, and social function, and quality of life, etc. Due to the return of day surgery patients to their homes following surgery, the doctors and the nurses require discrete observation and guidance. As a result, paying attention to the quality of recuperation following surgery of patients has critical clinical guiding significance. This guidance effectively pays attention to patient recovery, assists medical staff in taking some effective interventions for the quality of postoperative recovery of patients, and promotes high-quality nursing development. This review discusses the commonly used tools for postoperative evaluation in day surgery patients regarding pain assessment, quality of early postoperative recovery, and the quality of life. It examines some evaluation tools for their validity and application status in China and elsewhere. The clinical practice affects direct clinical personnel in evaluating the post-surgery quality of people undergoing daycare procedures.
Keywords: Day surgery; Assessment tools; Pain; Postoperative recovery; Quality of life
Citation: Nibaruta J, Xingjiao L, Xiaoxia H, Xiaoyu H, Xuefen C, Yufang L. Quality assessment tools for early postoperative recovery in day surgery patients. Anaesth. pain intensive care 2023;27(3):417−425; DOI: 10.35975/apic.v27i3.2201
Received: April 11, 2023; Reviewed: April 17, 2023; Accepted: May 12, 2023
Evaluation of cardiac operative risk and outcome using EuroSCORE II for coronary artery bypass graft surgery
Authors: Mokhtar Mohammad Nizam , Abdullah Farah Hanim , Rahman Mohd Ramzisham Abdul , Ooi Joanna Su Min 
Published: February 2024

Background: The original EuroSCORE was proposed in 1995, with a predicted mortality rate of 3.9%. The study aimed to assess the validity of the European System for Cardiac Operative Risk Evaluation-II (EuroSCORE II), presented in 2012, in predicting 30-day in-hospital mortality with the observed mortality in cardiac surgical patients operated in Universiti Kebangsaan Malaysia Medical Centre (UKMMC).Methodology: It was a retrospective study on patients who had undergone coronary artery bypass graft surgery during 6 y from January 01, 2011 to December 31, 2016, in UKMMC. Comparison between the output of the EuroSCORE II obtained and compared with the patients’ actual postoperative outcome. Results: The actual in-hospital mortality rate was 6.8%. In comparison, the predicted mortality rate by the median EuroSCORE II was 1.23%. Receiver operating characteristics (ROC) curve analysis showed an excellent discriminatory power with the area under the curve (AUC) of 0.844 (95% CI 0.705 - 0.983, P < 0.001) between the survivors and non-survivors. Conclusion: This single-center retrospective study of validation showed that the overall observed mortality was under-predicted by EuroSCORE II. However, it demonstrated a good calibration with excellent discriminatory power in predicting 30 days in-hospital mortality risk among patients undergoing coronary artery bypass graft surgery. Abbreviations: BMI: Body Mass Index; CCS: Canadian Cardiovascular Society; LVEF: Left Ventricular Ejection Fraction; NYHA: New York Heart Association; PA: Pulmonary Artery Key words: Risk assessment; Hospital mortality; Cardiac surgery Citation: Mokhtar MN, Abdullah FH, Rahman MRA, Ooi JSM. Evaluation of cardiac operative risk and outcome using EuroSCORE II for coronary artery bypass graft surgery. Anaesth. pain intensive care 2023;27(3):307−314; DOI: 10.35975/apic.v27i3.2228 Received: November 15, 2022; Reviewed: April 17, 2023; Accepted: April 19, 2023
Cerebritis as an initial presentation of systemic lupus erythematosus
Authors: Ashfaq Fahmina , Butt Nauman Ismat , Rasheed Muhammad Bilal , Ghoauri Muhammad Sohail Ajmal , Anser Aniqa 
Published: February 2024

Systemic lupus erythematosus (SLE), an autoimmune disease with multi-system manifestations, has several clinical presentations varying from mild muco-cutaneous involvement to severe multi-organ involvement. We report the case of an 18-year-old girl who presented generalized tonic clonic fits. She gave a history of generalized headaches, recurrent painless oral ulcers, photosensitivity, joint pains and low-grade intermittent fever. Magnetic resonance imaging (MRI) scan of the brain revealed T2WI/FLAIR hyperintense signals in bilateral frontal, parietal and occipital regions and magnetic resonance angiography of the brain demonstrated mild areas of luminal narrowing in M1 and M2 segments of middle cerebral arteries bilaterally, suggestive of lupus cerebritis. Anti-nuclear antibody (ANA) and Anti-DsDNA antibodies were positive. She was diagnosed as SLE and was prescribed corticosteroids, cyclophosphamide and hydroxychloroquine. This case highlights cerebritis as initial presentation of SLE.
Abbreviations: ANA- Anti-nuclear antibody; CRP- C-reactive protein; FLAIR- Fluid attenuated inversion recovery; SLE- Systemic lupus erythematosus;
Key words: ANA; Cerebritis; Headache; Systemic Lupus Erythematosus
Citation: Ashfaq F, Butt NI, Rasheed MB, Ghoauri MSA, Anser A. Cerebritis as initial presentation of systemic lupus erythematosus. Anaesth. pain intensive care 2023;27(4):604−608; DOI: 10.35975/apic.v27i4.2214
Received: May 23, 2023; Reviewed: May 28, 2023; Accepted: July 08, 2023
Comparison of granisetron 10 µg/kg vs 40 µg/kg intravenous for prophylaxis of shivering after spinal anesthesia for lower abdominal surgery
Authors: Wahid Witri Rahmania , Pradian Erwin , Prihartono Mohamad Andy 
Published: February 2024

Background & Objective: Postanesthetic shivering is one of the many complications during recovery that is marked by vasoconstriction and involuntary movements in several muscle groups and psychologically is an incredibly uncomfortable experience for the patient. The 5-HT3 receptor antagonist granisetron can potentially be used to manage postanesthetic shivering through the thermoregulation neurotransmission system. This study aims to compare the effects of administering 10 µg/kg or 40 µg/kg of granisetron intravenously on the grade of shivering post spinal anesthesia in lower abdominal surgeries. Methodology: This study was a single-blind experimental study conducted on 30 patients who underwent spinal anesthesia for lower abdominal surgeries in Dr. Hasan Sadikin Hospital Bandung. There were no statistical differences of age, weight, height, BMI, core temperature before anesthesia, block height, room temperature, total bleeding, input volume, duration of surgery, and use of ephedrine between the two intervention groups. Results: Administration of 40 µg/kg intravenous granisetron could maintain the body temperature above 36.56 °C , better than the 10 µg/kg intravenous granisetron with the lowest temperature at 35.31 °C. Regarding the grade of shivering, administration of 40 µg/kg granisetron IV was able to improve postanesthetic shivering up to grade 2 in 3 (20%) patients, while 10 µg/kg intravenous granisetron improved grade of shivering to grade 3 in 5 (33%) patients, these results were statistically significant (P < 0.05). Conclusion: In conclusion, administration of granisetron 40 µg/kg IV reduces the incidence and severity of shivering post spinal anesthesia, and maintains a better core temperature compared to granisetron 10 µg/kg IV.Keywords: 5-Ht3 Receptor Antagonist; Granisetron; Postanesthetic Shivering; Prophylaxis
Citation: Wahid WR, Pradian E, Prihartono MA. Comparison of granisetron 10 µg/kg vs 40 µg/kg intravenous for prophylaxis of shivering after spinal anesthesia for lower abdominal surgery. Anaesth. pain intensive care 2023;27(4):553−557; DOI: 10.35975/apic.v27i4.2265
Received: October 20, 2021; Reviewed: March 19, 2023; Accepted: June 22, 2023
The impact of hypoalbuminemia and its correlation with D-dimer and IL-6 on severity and 14-day mortality in COVID-19 patients
Authors: Utariani Arie , Hamzah Hamzah , Semedi Bambang Pujo , Wijaya Markus Gatot Sura 
Published: February 2024

Background & Objective: COVID-19 took the world by storm, but it also allowed the healthcare professionals to conduct big studies regarding various molecular and biochemical changes produced by the disease. We analyzed the impact of hypoalbuminemia on the severity and 14-day mortality in COVID-19 patients.
Methodology: It was an analytical observational, prospective cohort study design. Clinical and laboratory data collection was carried out in the COVID-19 isolation room of Dr. Soetomo Hospital, between July and October 2020. Serum albumin, D-dimer, and interleukin 6 (IL-6) levels were measured on the day of admission. Statistical analysis using Kolmogorov-Smirnov, Mann-Whitney test, regression test, ROC curve, and 14-day risk of mortality were tested using Univariate Cox Regression and Multivariate Cox Regression tests. The Kaplan Meier test was used to analyze life expectancy.
Results: Of the 119 study subjects, 71 (59.7%) were categorized as severe, and 48 (40.3%) as not severe. Out of the total, 36 (30.25%) patients expired within 14 days of admission, and 83 (69.75%) survived. Regression analysis showed the effect of age on albumin (P < 0.001), albumin on D-dimer (P = 0.003), albumin on disease severity (P < 0.001), and albumin on 14-day mortality (P < 0.001). Albumin was not significantly associated with IL-6 (P = 0.126). The value of albumin as a predictor of severity was 3.28 g/dL, with a sensitivity of 74.6% and a specificity of 77.1%.
Conclusion: The state of hypoalbuminemia affects the disease severity and mortality of COVID-19; albumin is significantly associated with D-dimer. Poor prognosis is expected if the albumin value < 3.28 in geriatric and obese patients with a high 14-days mortality.
Key words: Albumin; COVID-19; D-dimer; Hypoalbuminemia; IL-6; Severity; Mortality.
Citation: Utariani A, Hamzah H, Semedi BP, Sura Wijaya MG. The impact of hypoalbuminemia and its correlation with D-dimer and IL-6 on severity and 14-day mortality in COVID-19 patients. Anaesth. pain intensive care 2023;27(5):440−450; DOI: 10.35975/apic.v27i5.1795
Received: February 12, 2022; Reviewed: May 23, 23; Accepted: July 08, 2023
Anesthetic implications in managing a case of placenta percreta: A case report
Authors: Rubab Um I. 
Published: February 2024

Placenta percreta is the extreme end of the placenta accreta spectrum. It involves the placenta which invades through out the wall of the myometrium, crossing the uterus and getting adherent to other pelvic or abdominal organs. Surgical and anaesthetic management of placenta percreta can be challenging in such scenarios, especially in the cases where placenta percreta is getting a direct feed from aorta. It carries a high risk of maternal and fetal mortality and morbidity. I present a case of placenta percreta, G5P4, with a history of previous 3 Caesarean sections and placenta previa. Admitted with severe abdominal pain at 23 weeks. Imaging was suggestive of placenta percreta with placenta extending beyond the uterus, getting adherent to the urinary bladder, and getting direct feed from the aorta along with neovascularisation in the pelvis. She was managed by a multidisciplinary approach, caesarean delivery followed by a hysterectomy, and urinary bladder dome repair was carried out. The intraoperative course was complicated by severe obstetric haemorrhage which was successfully managed with fluids and blood products.
Keywords: Placenta Accreta Spectrum; Placenta Percreta; Massive Obstetric Hemorrhage; Massive Transfusion Protocol
Citation: Rubab UI. Anesthetic implications in managing a case of placenta percreta: A case report. Anaesth. pain intensive care 2023;27(5):614−618; DOI: 10.35975/apic.v27i5.2240
Received: April 07, 2023; Reviewed & Accepted: July 01, 2023