bluuebunny/crossref_metadata_2025_split huggingface dataset:
El Estilo de Liderazgo Transformacional de los Docentes del Área de Ciencias Básicas del Programa Educativo de Ingeniería Industrial del TecNM/ITSLP y su Relación con el Desempeño Académico de los Estudiantes
Authors: Garcés Rodríguez Angela Rebeca 
Published: January 2024

El objetivo del presente trabajo es identificar la relación que existe entre el estilo de liderazgo transformacional de los docentes que forman parte del departamento de ciencias básicas y que imparte su asignatura en el programa de ingeniería industrial del Tecnológico Nacional de México/Instituto Tecnológico de San Luis Potosí y el desempeño académico de los estudiantes. La investigación tiene un enfoque cuantitativo, con diseño no experimental, de corte transversal y es un estudio correlacional-descriptivo. Para la recolección de datos de desempeño académico de estudiantes se extrajo del reporte final del semestre agosto diciembre 2022 por docente y se aplicó una encuesta de liderazgo transformacional a los docentes que imparten clase al programa educativo de ingeniería industrial en materias de ciencias básicas, por medio del cuestionario multifactorial de liderazgo, versión corta denominado MLQ (form 5X-Short). En el análisis se encontró que sólo el 3% de los grupos estudiados que alcanzaron la competencia, tiene nivel excelente y el 20% de la población de estudiantes no alcanzó la competencia de desempeño académico y el 13% de estudiantes desertó. Y de la población de docentes sólo el 21.74 % tiene un liderazgo transformacional excelente. El resultado de este trabajo demostró que el liderazgo transformacional y sus dimensiones tiene una correlación positiva y significativa con el desempeño académico de los estudiantes.
Síndrome de Burnout y Calidad del Sueño en Médicos
Authors: Rodríguez Torres María Julieta , Medina Hernández Oscar , Moreno Contreras Marco Vinicio , López Pérez Isaac , Castillo Hernández Carla Josefina 
Published: January 2024

El Síndrome de Burnout es consecuencia del estrés crónico, caracterizándose por despersonalización, agotamiento emocional y sensación de pobre realización personal, teniendo manifestaciones psiciológicas y físicas, incluyendo variaciones en la calidad y patrón del sueño, considerada una función fisiológica primordial para conservar la integridad de la salud de los individuos.La presente investigación pretende determinar la presencia de Síndrome de Burnout en médicos de un hospital, a través de (MBI-HSS), y buscar su asociación a la calidad del sueño aplicando (PSQI). El diseño fue observacional, analítico, prospectivo, corte transversal. Se utilizó Chi-cuadrada (X2) para analizar la asociación entre las variables principales, con una significancia estadística de p< 0.05, el resto se expresó con estadística descriptiva a través de medidas de tendencia central para las variables cuantitativas; frecuencias y porcentajes para las variables cualitativas. Obteniendo prevalencia del Síndrome de Burnout en médicos no familiares del 66%. Mediana en la antigüedad laboral de 12 años, media en la edad de 44 años, y moda en el número de empleos de 2. El 60.3% de los sujetos con mala calidad del sueño de categoría de médico no familiar y el 80% de las personas con Síndrome de Burnout tuvo una mala calidad del sueño, concluyendo que existe relación entre el Síndrome de Burnout y una mala calidad del sueño.
Développer le pouvoir d’agir des praticiens hospitaliers, pour « bien faire » et impacter : le cas du centre hospitalier Calvi-Balagne
Authors: Moretti Romain , Frimousse Soufyane 
Published: January 2024

La crise sanitaire de la covid 19 qui semblait sonner la fin de l’hôpital public, a conduit à une prise de conscience accélérée, de la part des acteurs hospitaliers et des pouvoirs publics, des maux du secteur de la santé publique. L’essor du Nouveau Management Public caractérisé au sein de l’hôpital public par une hybridation de rôle des professionnels de santé, conduit à une perte de sens au travail chez ces derniers et à un choc entre identités professionnelles au sein de la structure, avec d’un coté la sphère administrative et de l’autre la sphère praticienne. Afin de répondre à ces enjeux, cet article s’intéresse à l’essor du pouvoir d’agir, qui offre au collaborateur des conditions pour tendre vers l’essence de son métier et ainsi contribuer à la construction, ou la reconstruction, du sens au travail pour les professionnels de santé. La méthodologie qualitative mobilisée dans cette étude met en évidence, à travers la réalisation de cartes cognitives et d’entretiens semi directifs, les points de rapprochement entre les visions administratives et praticiennes. Les résultats invitent à dépasser l’idée d’un « médecin-gestionnaire » pour tendre vers une approche systémique et apprenante, permise par l’essor d’un environnement capacitant.
Territoires zéro chômeur de longue durée
Authors: Semenowicz Philippe , Fretel Anne , Jany-Catrice Florence , Vatan Sylvain 
Published: January 2024

L’expérimentation territoires zéro chômeur de longue durée (TZC) a été introduite dans le débat public comme un « nouveau modèle » de lutte contre le chômage de longue durée. Pourtant, le projet présente dès l’origine des similitudes avec les dispositifs de l’insertion par l’activité économique (IAE). Dans quelle mesure TZC constitue-t-il une rupture avec l’IAE ? Sur la base d’une enquête de terrain menée durant trois ans sur l’un des territoires ayant expérimenté TZC, complétée par une série d’entretiens semi-directifs auprès d’acteurs nationaux du projet, nous abordons cette question sous l’angle d’une comparaison de leurs modèles socioéconomiques respectifs. Nous mettons en évidence combien l’ambition originelle du projet le positionne à distance des évolutions de l’IAE. Pour autant, l’opérationnalisation de l’expérimentation produit des formes de convergence avec cette dernière.
Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl–Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation
Authors: Ting Kenneth K Y , Yu Pei , Iyayi Mudia , Dow Riley , Hyduk Sharon J , Floro Eric , Ibrahim Hisham , Karim Saraf , Polenz Chanele K , Winer Daniel A , Woo Minna , Rocheleau Jonathan , Jongstra-Bilen Jenny , Cybulsky Myron I 
Published: January 2024

Abstract
The accumulation of lipid and the formation of macrophage foam cells is a hallmark of atherosclerosis, a chronic inflammatory disease. To better understand the role of macrophage lipid accumulation in inflammation during atherogenesis, we studied early molecular events that follow the accumulation of oxidized low-density lipoprotein (oxLDL) in cultured mouse macrophages. We previously showed that oxLDL accumulation downregulates the inflammatory response in conjunction with downregulation of late-phase glycolysis. In this study, we show that within hours after LPS stimulation, macrophages with accumulated oxLDL maintain early-phase glycolysis but selectively downregulate activation of AKT2, one of three AKT isoforms. The inhibition of AKT2 activation reduced LPS-induced ATP citrate lyase activation, acetyl-CoA production, and acetylation of histone 3 lysine 27 (H3K27ac) in certain inflammatory gene promoters. In contrast to oxLDL, multiple early LPS-induced signaling pathways were inhibited in macrophages with accumulated cholesterol, including TBK1, AKT1, AKT2, MAPK, and NF-κB, and early-phase glycolysis. The selective inhibition of LPS-induced AKT2 activation was dependent on the generation of mitochondrial oxygen radicals during the accumulation of oxLDL in macrophages prior to LPS stimulation. This is consistent with increased oxidative phosphorylation, fatty acid synthesis, and oxidation pathways found by comparative transcriptomic analyses of oxLDL-loaded versus control macrophages. Our study shows a functional connection between oxLDL accumulation, inactivation of AKT2, and the inhibition of certain inflammatory genes through epigenetic changes that occur soon after LPS stimulation, independent of early-phase glycolysis.
Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state
Authors: Wang Yubo , Zhang Ling , Lyu Tianjie , Cui Lu , Zhao Shunying , Wang Xuechun , Wang Meng , Wang Yongjun , Li Zixiao 
Published: January 2024

Abstract
Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome. We constructed a mouse model of transient middle cerebral artery occlusion and treated the mice with lipopolysaccharide to induce a hyperinflammatory state. To investigate the effect of DNA methylation on stroke, we used small molecule inhibitors to restrain the function of key DNA methylation and demethylation enzymes. 2,3,5-Triphenyltetrazolium chloride staining, neurological function scores, neurobehavioral tests, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot assay were used to evaluate the effects after stroke in mice. We assessed changes in the global methylation status by measuring DNA 5-mc and DNA 5-hmc levels in peripheral blood after the use of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tissue 2,3,5-triphenyltetrazolium chloride staining showed an increase in infarct volume, which was accompanied by a decrease in neurological scores and worsening of neurobehavioral performance. The levels of inflammatory factors interleukin 6 and interleukin-1 beta in ischemic brain tissue and plasma were elevated, indicating increased inflammation. Related inflammatory pathway exploration showed significant overactivation of nuclear factor kappa B. These results suggested that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following stroke. Further, the effects were reversed by inhibition of DNA demethylation. Our findings suggest that DNA methylation regulates the inflammatory response in stroke and has an important role in the functional outcome of hyperinflammatory stroke.
Clinical value of oral contrast-enhanced ultrasonography in diagnosis of gastric tumors
Authors: Wang Chuan-Yu , Fan Xiao-Jing , Wang Fei-Liang , Ge Yue-Yue , Cai Zhao , Wang Wei , Zhou Xin-Ping , Du Jun , Dai De-Wei 
Published: January 2024

BACKGROUND
The incidence of gastric cancer remains high, and it is the sixth most common cancer and the fourth leading cause of cancer deaths worldwide. Oral contrast-enhanced ultrasonography is a simple, non-invasive, and painless method for the diagnosis of gastric tumors.
AIM
To explore the diagnostic value of oral contrast-enhanced ultrasonography for the detection of gastric tumors.
METHODS
The screening results based on oral contrast-enhanced ultrasonography and electronic gastroscopy were compared with those of the postoperative pathological examination.
RESULTS
Among 42 patients with gastric tumors enrolled in the study, the diagnostic accordance rate was 95.2% for oral contrast-enhanced ultrasonography (n = 40) and 90.5% for electronic gastroscopy (n = 38) compared with postoperative pathological examination. The Kappa value of consistency test with pathological findings was 0.812 for oral contrast-enhanced ultrasonography and 0.718 for electronic gastroscopy, and there was no significant difference between them (P = 0.397). For the TNM staging of gastric tumors, the accuracy rate of oral contrast-enhanced ultrasonography was 81.9% for the overall T staging and 50%, 77.8%, 100%, and 100% for T1, T2, T3, and T4 staging, respectively. The sensitivity and specificity were both 100% for stages T3 and T4. The diagnostic accuracy rate of oral contrast-enhanced ultrasonography was 93.8%, 80%, 100%, and 100% for stages N0, N1-N3, M0, and M1, respectively.
CONCLUSION
The accordance rate of qualitative diagnosis by oral contrast-enhanced ultrasonography is comparable to that of gastroscopy, and it could be used as the preferred method for the early screening of gastric tumors.
Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification
Authors: Du Yu-Hua , Zhao Jian-Jun , Li Xia , Huang Shi-Cong , Ning Na , Chen Guo-Qing , Yang Yi , Nan Yi , Yuan Ling 
Published: January 2024

BACKGROUND
Pachymic acid (PA) is derived from Poria cocos. PA has a variety of pharmacological and inhibitory effects on various tumors. However, the mechanism of action of PA in gastric cancer (GC) remains unclear.
AIM
To investigate the mechanism of PA in treating GC via the combination of network pharmacology and experimental verification.
METHODS
The GeneCards and OMIM databases were used to derive the GC targets, while the Pharm Mapper database provided the PA targets. Utilizing the STRING database, a protein-protein interaction network was constructed and core targets were screened. The analyses of Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis were conducted, and molecular docking and clinical correlation analyses were performed on the core targets. Ultimately, the network pharmacology findings were validated through in vitro cell assays, encompassing assessments of cell viability, apoptosis, cell cycle, cloning, and western blot analysis.
RESULTS
According to network pharmacology analysis, the core targets were screened, and the PI3K/AKT signaling pathway is likely to be the mechanism by which PA effectively treats GC, according to KEGG enrichment analysis. The experimental findings showed that PA could control PI3K/AKT signaling to prevent GC cell proliferation, induce apoptosis, and pause the cell cycle.
CONCLUSION
Network pharmacology demonstrated that PA could treat GC by controlling a variety of signaling pathways and acting on a variety of targets. This has also been supported by in vitro cell studies, which serve as benchmarks for further research.
Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection
Authors: Li Ao-Han , Bu Su , Wang Ling , Liang Ai-Min , Luo Hui-Yu 
Published: January 2024

BACKGROUND
Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer. However, there is a debate concerning their differential effects on cognitive function, anxiety, and depression in patients undergoing this procedure.
AIM
To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function, anxiety, depression, and organ function in patients undergoing radical resection of gastric cancer.
METHODS
A total of 80 patients were involved in this research. The subjects were divided into two groups: Propofol group and sevoflurane group. The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment (LOTCA), and anxiety and depression were assessed with the aid of the self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Hemodynamic indicators, oxidative stress levels, and pulmonary function were also measured.
RESULTS
The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group. Additionally, the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group. The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group. Moreover, the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group.
CONCLUSION
Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer. Propofol anesthesia has a minimal effect on patients' pulmonary function, consequently enhancing their postoperative recovery. Sevoflurane anesthesia causes less impairment on patients' cognitive function and mitigates negative emotions, leading to an improved postoperative mental state. Therefore, the selection of anesthetic agents should be based on the individual patient's specific circumstances.
Respon metabolik sapi madura pada musim masah di Kabupaten Pamekasan
Authors: Agustina Desi K. , Kuswati Kuswati , Kurnadi Bambang , Hidayati Nurul 
Published: January 2024

Abstract
The purpose of this study was to evaluate the effect of environmental factors, namely seasonal changes and nutritional factors on the adaptive abilities shown by the metabolic response of Madura cattle. The research was conducted in Pademawu District, Pamekasan Regency, East Java from February to June 2022. The research material included 45 Madura cattle which included differences in sex and age. Metabolic response was analyzed descriptively. The results of the study obtained blood urea nitrogen (BUN) concentrations in male and female Madura cattle with different ages, including; 20.96 ± 6.79; 22.04 ± 5.12; 18.63 ± 1.94; 15.86 ± 2.72; 27.42 ± 14.5; 21.40 ± 8.2. Triglyceride concentrations in Madura cattle successively at different sexes and ages, namely; 11.00 ± 3.53; 21.60 ± 7.4; 11.00 ± 1.94; 12.00 ± 2.72; 9.20 ± 5.65; 11.00 ± 2.40. Glucose concentrations in male and female Madura sai with different ages, namely; 83.00 ± 16.90; 102.40 ± 13.90; 97.60 ± 12.60; 110.00 ± 13.3; 95.00 ± 8.4; 54.80 ± 8.7. Blood protein concentrations respectively; 7.70 ± 1.28; 10.30 ± 2.09; 10.14 ± 2.48; 9.16 ± 1.73; 9.56 ± 2.01; 6.16 ± 1.55. In general, the metabolic response of male and female Madura cattle at different age levels in the wet season is within the normal range. This shows that it can adapt well.
Keywords: Madura cattle; Metabolic; Response; Season

Abstrak
Tujuan penelitian ini adalah mengevaluasi respon metabolik sapi Madura pada musim basah. Materi penelitian meliputi 45 ekor sapi Madura yang meliputi perbedaan jenis kelamin dan umur. Respon metabolic dianalisis secara deskriptif, hasil penelitian didapatkan konsentrasi Blood urea nitrogen (BUN) pada sapi Madura jantan dan betina dengan umur berbeda antara lain: 20,96 ± 6,79; 22,04 ± 5,12; 18,63 ± 1,94; 15,86 ± 2,72; 27,42 ± 14,5; 21,40 ± 8,2. Konsentrasi trigliseride pada sapi Madura berturut-turut pada jenis kelamin dan umur yang berbeda yaitu; 11,00 ± 3,53; 21,60 ± 7,4; 11,00 ± 1,94; 12,00 ± 2,72; 9,20 ± 5,65; 11,00 ± 2,40. Konsentrasi Glukosa pada sapi Madura jantan dan betina dengan umur berbeda yaitu: 83,00 ± 16,90; 102,40 ± 13,90; 97,60 ± 12,60; 110,00 ± 13,3; 95,00 ± 8,4; 54,80 ± 8,7. Konsentrasi protein darah berturut-turut: 7,70 ± 1,28; 10,30 ± 2,09; 10,14 ± 2,48; 9,16 ± 1,73; 9,56 ± 2,01; 6,16 ± 1,55. Respon metabolic sapi Madura jantan maupun betina pada tingkatan umur yang berbeda di musim basah berada dalam kisaran normal.
Kata kunci: Metabolik; Musim; Respon; Sapi Madura
PELATIHAN PENGGUNAAN DOMPET DIGITAL UNTUK MEMPERMUDAH USAHA DALAM AKSI MULTIMEDIA BERBAGI 7 (AMUBA 7) DISELENGGARAKAN SECARA LIVESTREAMING
Authors: Rahayu Dwi Mandasari 
Published: January 2024

Meningkatknya kebutuhan barang dan jasa bagi masyarakat Indonesia maka kita perlu mencari alternatif dalam proses pembayaran yang bersifat praktis, aman dan menghemat waktu. Oleh karena itu, transaksi non tunai menjadi pilihan dalam proses pembayaran. Adanya perkembangan teknologi, informasi dan komunikasi dapat memudahkan proses transaksi yang dilakukan secara instan dan fleksibel menggunakan dompet digital. Hal ini menjadi strategi yang dilakukan pemilik usaha dalam memudahkan pelanggan melakukan transaksi pembayaran untuk menghadapi persaingan usaha. Adapun tujuan kegiatan ini untuk berbagi ilmu dan pengalaman terhadap generasi muda yang ingin berusaha dalam mempermudah proses transaksi menggunakan dompet digital, serta meningkatkan usahanya sehinga memiliki kepercayaan diri dan kemampuan bersaing di dunia luar. Metode yang dilakukan pada pengabdian kepada masyarakat ini berupa pelatihan yang dilaksanakan secara livestreaming. Kegiatan ini diperuntukkan bagi pengguna media sosial dan tunawisma di beberapa daerah. Hasil dari pelatihan ini yaitu berupa peningkatan softskill dalam penggunaan dan pememanfaatan dompet digital untuk mempermudah usaha generasi muda.
Implementasi Metode Simple Additive Weighting (SAW) dalam Pemilihan Sekolah Ramah Anak
Authors: Ahmad Sulistiawati Rahayu , M Salim , PNua Salma 
Published: January 2024

Child-Friendly School is a program aimed at achieving safe, clean, healthy, caring, and environmentally conscious conditions that ensure the fulfillment of children's rights and protection from violence, discrimination, and other forms of mistreatment while they are in educational institutions. It also supports children's participation, particularly in planning, policies, learning, and supervision. One of the objectives of developing the Child-Friendly School Policy is to fulfill, guarantee, and protect children's rights, as well as to ensure that educational institutions can develop children's interests, talents, and abilities, and prepare them to be responsible for a tolerant, respectful, collaborative life for progress and a spirit of peace.
The research aims to design a Web-based Decision Support System for Selecting Child-Friendly Schools in the Education Office of Gorontalo City using the Simple Additive Weighting (SAW) method. The research adopts the Waterfall method as the research approach and conducts Whitebox and Blackbox testing for the system. The research findings indicate that the system can facilitate schools applying for child-friendly school certification from the Education Office of Gorontalo City. It provides a transparent ranking output based on the assessment of predetermined criteria weights. The system can perform quick, accurate, and precise weighting calculations using the SAW decision support method, and it provides information on the suitability status based on the weight values derived from the matrix summation after the 'SAW method' button is processed
Digitalisasi Warisan Benda Bersejarah Pada Kawasan Pura Pucak Penulisan Menggunakan Metode Waterfall
Authors: Aditama Putu Wirayudi , Juniantari Ni Komang Dani , Sandhiyasa I Made Subrata , Sarasvananda Ida Bagus Gede , Sudipa I Gede Iwan 
Published: January 2024

Sukawana Village has many temples and has a very interesting historical heritage so that it is used as one of the tourism sites, this village has a temple called Pura Pucak Penulisan which is located in Sukawana Village, this temple has many historical objects that have not been known by the surrounding community. The solution to overcome these problems is the digitization of historical objects in Pura Pucak Penulisan, Sukawana Village. The system development method uses the Waterfall method because it can provide a structured solution approach in producing a website as a medium for digitizing historical objects in the Pucak Penulisan temple area, Sukanawa Village. The implications of research with digitization can help the surrounding community and other people find information about historical objects in Pura Pucak Penulisan without having to see it directly to the place. Based on the results of research 103 respondents from the community regarding the digitization of historical objects in Pura Pucak Penulisan showed 98.1% with the digitization of historical objects in Pura Pucak Penulisan which provided clear information about the historical objects in Pura Pucak Penulisan, this was also supported by 21 respondents from the Sukawana Village Office showing 85% considered it important to digitize historical objects in Pura Pucak Penulisan, to maintain its cultural assets. And in the black-box testing results get the expected results with the appropriate test.