bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dampak Pandemi Covid-19 Terhadap Pergeseran Lapangan Usaha PDRB Kabupaten dan Kota di Provinsi Sumatera Selatan
Authors: Tunut Susyanto , Eka Sakti Ratih 
Published: January 2024

This study aims to analyze the impact of the Covid-19 pandemic on shifts in business fields in Regency and City GRDP in South Sumatra Province. The research method used is descriptive quantitative. The results of the study are (1) the average GRDP in the Regency Region after the pandemic increased from 14,444.63 to 16,831.04. This shows that there has been a recovery in the contribution of the Business Field to GRDP. The Business Fields which contributed quite a lot (2.7 percent) but have not yet recovered are Real Estate; (2) The average GRDP in the City Region after the pandemic fell from 27,459.3 to 19,272.2. This shows that there has been no recovery of GRDP; (3) The results of the quadrant analysis show that the shift in Business Fields that occurs is caused by a decreased contribution to GRDP, slowing growth in Business Fields, and a combination of both. In conclusion, there is a shift in Business Field which has a significant contribution to changes in GRDP in the City area.
Keywords: GRDP Shift, Impact of the Covid-19 Pandemic
Kompensasi dan Budaya Organisasi Terhadap Turnover pada PT. BPR Gunung Slamet Cilacap
Authors: Pramono Selindha Rosanti , Wulansari Puspita 
Published: January 2024

The purpose of this study is to ascertain how compensation and organizational culture at PT. BPR Gunung Slamet Cilacap affect turnover. This study used a quantitative methodology that included multiple linear regression analysis and descriptive analysis approaches. According to the study's findings, the combined impact of organizational culture and compensation on turnover are known to be 51.2%, with other factors influencing the remaining 48.8%. Conclusion: Both salary and organizational culture have a considerable impact on the turnover variable, though not equally. salary has a significant positive impact on turnover, whereas organizational culture has an enormous adverse influence.
Keywords: Organizational Culture, Compensation, Turnover
Analisis Good Corporate Governance dan Karakteristik Perusahaan Terhadap Pengungkapan Corporate Social Responsibility
Authors: Agustia Elsa Sabrina , Haryati Tantina 
Published: January 2024

This research aims to study how corporate governance and company characteristics influence corporate social responsibility disclosure. There are many components that form effective corporate governance, including independent commissioners, audit committee, managerial ownership, board of directors, profitability and leverage. The population of this research is food and beverage sub-sector manufacturing companies listed on the Indonesia Stock Exchange during the 2017-2021 research period. The sample determination process used purposive sampling, obtaining 40 samples with a period of 5 years. The research results show that the audit committee and managerial ownership variables influence CSR disclosure. Meanwhile, the variables independent commissioner, board of directors, profitability and leverage have no effect on CSR disclosure.
Keywords: Good Corporate Governance (GCG), Corporate Social Responsibility (CSR)
Pengaruh Pengetahuan Kewirausahaan, Motivasi Berwirausaha dan Lingkungan Keluarga Terhadap Minat Berwirausaha Mahasiswa
Authors: Nur Shanty Arisma Lusia , Subroto Waspodo Tjipto 
Published: January 2024

This study aims to analyze the effect of entrepreneurial knowledge, entrepreneurial motivation and family environment on student entrepreneurial interest. The research method is causal associative with a quantitative approach. The population used is students of PE, PAK, PAP, and PTN Study Programs at the Faculty of Economics and Business, Surabaya State University class of 2019 totaling 214 students. Sampling using convenience sampling technique amounted to 139 students. Sampling using convenience sampling technique of 139 students. The data analysis technique used is multiple linear regression analysis and classical assumption test with the help of the SPSS Version 25 for Windows program. The results showed entrepreneurial knowledge, entrepreneurial motivation and family environment partially and simultaneously affect the interest in entrepreneurship, with the contribution of the magnitude of the influence of 58.8%. Conclusion, the influence of entrepreneurial knowledge, entrepreneurial motivation and family environment on student entrepreneurial interest.
Keywords: Entrepreneurial Interest, Entrepreneurial Knowledge, Entrepreneurial Motivation, Family Environment
Model Kepemimpinan Nasional Dan Pemerataan Pembangunan Di Indonesia Model Of National Leadership And Equity Development In Indonesia
Authors: Maruapey Muhammad Husein , Sudarsa Agus Suarman , Wijayanti Windi , Wahyudin Wahyudin , Jakaria Muhammad Jejen 
Published: January 2024

Seorang pemimpin sangat berperan besar dalam menentukan berhasil atau tidaknya suatu organisasi mencapai tujuan yang telah ditetapkan. Hal ini ditentukan oleh gaya kepemimpinan yang dijalankan dalam organisasi tersebut. Bagi suatu negara, kepemimpinan seorang pemimpinan akan menentukan dalam mencapai tujuan negara yang juga erat kaitannya dengan pembangunan nasional. Persoalan pembangunan merupakan isu makro yang terus menjadi fokus pemerintah. Berbagai kebijakan pun dikeluarkan pemerintah dalam rangka meningkatkan pembangunan nasional. Namun, pembangunan dalam arti luas ini yang tidak hanya sebatas pembangunan infrastruktur secara fisik, masih menjadi pekerjaan rumah bagi pemerintah. Tujuan dari penelitian ini adalah menganalisis jenis-jenis model kepemimpinan, mengetahui permasalahan pembangunan di Indonesia dan merumuskan model kepemimpinan dalam mewujudkan pemerataan pembangunan di Indonesia.Penelitian ini menggunakan pendekatan deskriptif kualitatif. Teknik pengumpulan data yang digunakan dalam penelitian ini sesuai dengan tujuan penelitian ini yaitu studi literatur. Kepemimpinan transformasional dapat merupakan model yang dapat dimiliki oleh seorang pemimpin nasional. Tercapai atau tidaknya pemerataan pembangunan di Indonesia akan ditentukan oleh seorang pemimpin nasional yang memiliki jiwa kepemimpinan nasional. Pemimpin nasional harus dapat memahami secara mendasar dan memetakan apa yang menjadi permasalahan pembangunan dan model pembangunan yang sedang berkembang, sehingga kebijakan yang dikeluarkan dapat tepat sasaran dan pemerataan pembangunan dapat diwujudkan.
Kata kunci: kepemimpinan, kepemimpinan nasional, pemerataan pembangunan
Pengaruh Self Efficacy terhadap Kemampuan Pemahaman Relasional Mahasiswa Matematika
Authors: Zaini Anissa Putri , Nengsi Heny Sri Widarna , Halki M. Febri Ikhsan 
Published: January 2024

Every individual must have self-efficacy as a form of belief in themselves. Self efficacy can affect the ability of understanding, knowledge and reasoning in problem solving both daily life problems and mathematical problems. In this study we want to see the effect of self efficacy on the ability of relational understanding of mathematics students at Fatmawati Sukarno State Islamic University Bengkulu. The approach of this research is quantitative by using simple regression method and the population is mathematics students of Fatmawati Sukarno State Islamic University Bengkulu with a sample of 32 students using stratified random sampling technique. The instruments applied in this study were questionnaires and tests. Based on the results of the study, it is concluded that 43% of relational understanding ability is positively and significantly influenced by self efficacy. The higher the value of self efficacy, the higher the level of relational ability in students in working on a math problem.

Keywords: Self-Efficacy, Relational Comprehension Skills
The Digital Craftsman
Authors: Toscano Keegan 
Published: January 2024

<p>Craftsmanship within the context of contemporary architectural design has failed to play a meaningful role, confined by nostalgic perceptions. Likewise, the architect has also forgone this territory of design and making due to the dependencies of abstract processes, severing the response of a material-based approach. As recognized, craftsmanship serves to provide this necessary dialogue between the processes of making and its translation into an expressive, material-based architecture. The digital craftsman re-evaluates this dialogical understanding by adapting some of the architects’ contemporary tools in developing a new design methodology towards architectural craftsmanship. </p>
<p>This thesis examines various facets of the craftsman’s process, strategically situating a distinctive design approach, evaluated through a series of design-based investigations illustrating the manifested nuances of craftsmanship in architecture. This novel perspective offers the architect a valuable means of responding to the notion of craftsmanship as a valid form of design and making within our contemporary architectural discourse.</p>
Multi-scale in silico and ex silico mechanics of 3D printed cochlear implants for local drug delivery
Authors: Isaakidou A. , Ganjian M. , van Hoften R. , Saldivar M. C. , Leeflang M. A. , Groetsch A. , Wątroba M. , Schwiedrzik J. , Mirzaali M. J. , Apachitei I. , Fratila-Apachitei L. E. , Zadpoor A. A. 
Published: January 2024

The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects. Cochlear implants offer a potential solution by providing localized and sustained drug delivery to the cochlea. While the mechanical characterization of both the implants and their constituent material is crucial to ensure functional performance and structural integrity during implantation, this aspect has been mostly overlooked. This study proposes a novel methodology for the mechanical characterization of our recently developed cochlear implant design, namely, rectangular and cylindrical, fabricated using two-photon polymerization (2 PP) with a novel photosensitive resin (IP-Q™). We used in silico computational models and ex silico experiments to study the mechanics of our newly designed implants when subjected to torsion mimicking the foreseeable implantation procedure. Torsion testing on the actual-sized implants was not feasible due to their small size (0.6 × 0.6 × 2.4 mm³). Therefore, scaled-up rectangular cochlear implants (5 × 5 × 20 mm³, 10 × 10 × 40 mm³, and 20 × 20 × 80 mm³) were fabricated using stereolithography and subjected to torsion testing. Finite element analysis (FEA) accurately represented the linear behavior observed in the torsion experiments. We then used the validated Finite element analysis models to study the mechanical behavior of real-sized implants fabricated from the IP-Q resin. Mechanical characterization of both implant designs, with different inner porous structures (pore size: 20 μm and 60 μm) and a hollow version, revealed that the cylindrical implants exhibited approximately three times higher stiffness and mechanical strength as compared to the rectangular ones. The influence of the pore sizes on the mechanical behavior of these implant designs was found to be small. Based on these findings, the cylindrical design, regardless of the pore size, is recommended for further research and development efforts.
Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice
Authors: Zhang Hang , Dong Miaomiao , Zheng Jixia , Yang Yapeng , He Jinhui , Liu Tianhao , Wei Hong 
Published: January 2024

BackgroundIonizing radiation can cause intestinal microecological dysbiosis, resulting in changes in the composition and function of gut microbiota. Altered gut microbiota is closely related to the development and progression of radiation-induced intestinal damage. Although microbiota-oriented therapeutic options such as fecal microbiota transplantation (FMT) have shown some efficacy in treating radiation toxicity, safety concerns endure. Therefore, fecal bacteria-free filtrate transplantation (FFT), which has the potential to become a possible alternative therapy, is well worth investigating. Herein, we performed FFT in a mouse model of radiation exposure and monitored its effects on radiation damage phenotypes, gut microbiota, and metabolomic profiles to assess the effectiveness of FFT as an alternative therapy to FMT safety concerns.ResultsFFT treatment conferred radioprotection against radiation-induced toxicity, representing as better intestinal integrity, robust proinflammatory and anti-inflammatory cytokines homeostasis, and accompanied by significant shifts in gut microbiome. The bacterial compartment of recipients following FFT was characterized by an enrichment of radioprotective microorganisms (members of family Lachnospiraceae). Furthermore, metabolome data revealed increased levels of microbially generated short-chain fatty acids (SCFAs) in the feces of FFT mice.ConclusionsFFT improves radiation-induced intestinal microecological dysbiosis by reshaping intestinal mucosal barrier function, gut microbiota configurations, and host metabolic profiles, highlighting FFT regimen as a promising safe alternative therapy for FMT is effective in the treatment of radiation intestinal injury.
PlasmaBlade-assisted surgical septal myectomy: technique and our experience
Authors: Garg Pankaj , Lykins Amy , Alomari Mohammad , Reynolds Jordan P. , Johnson Elizabeth , Sareyyupoglu Basar 
Published: January 2024

BackgroundThe pulsed-electron avalanche knife (PEAK) PlasmaBlade provides an atraumatic, scalpel-like cutting precision and electrocautery-like hemostasis. PlasmaBlade operates near body temperature, and its long, thin, and malleable tip can overcome the limitations of a surgical knife. In this study, we aimed to evaluate our clinical experience and histopathological outcomes of septal myectomy using PlasmaBlade.MethodsElectronic medical records were reviewed for preoperative, operative, and follow-up data of the patients who underwent septal myectomy using PEAK PlasmaBlade at our institute between January 2019 and December 2022. Histopathology of the myectomy specimens was reviewed for the depth of muscle necrosis and compared with the left atrial appendage (LAA) specimen.ResultsTwenty-nine patients underwent septal myectomy using the PEAK PlasmaBlade. No mortality was reported. The mean age was 60.6 ± 12.5 years, and 58.6% of patients were male. Peak left ventricular outflow tract (LVOT) gradients were 40.5 ± 34.9 mmHg at rest and 56.5 ± 34.9 mmHg after provocation. Concomitant procedures performed were LAA ligation in 20 (69.0%), aortic valve replacement in 5 (17.2%), and coronary artery bypass grafting in 3 (10.3%) patients. Postoperative complications were complete heart block in one (3.4%) and ventricular septal defect in two (6.9%) patients. Both the ventricular septal defects were identified intraoperatively and repaired. Histopathology of myectomy specimens demonstrated cautery artifact limited to &lt;50 µm depth compared to &gt;1,000 µm with conventional electrocautery. At a mean follow-up of 8.4 ± 10.3 months, the mean LVOT gradient was 4.4 ± 5.8 mmHg at rest and 9.5 ± 3.3 mmHg after provocation. All patients were alive and in New York Heart Association class I/II. No patient developed complications or required reintervention or reoperation.ConclusionAdequate septal myectomy can be precisely and safely performed using the PEAK PlasmaBlade with minimal collateral damage.
Progressions of the correlation between lipid metabolism and immune infiltration characteristics in gastric cancer and identification of BCHE as a potential biomarker
Authors: Wang Shibo , Huang Xiaojuan , Zhao Shufen , Lv Jing , Li Yi , Wang Shasha , Guo Jing , Wang Yan , Wang Rui , Zhang Mengqi , Qiu Wensheng 
Published: January 2024

BackgroundGlobally, gastric cancer (GC) is a category of prevalent malignant tumors. Its high occurrence and fatality rates represent a severe threat to public health. According to recent research, lipid metabolism (LM) reprogramming impacts immune cells’ ordinary function and is critical for the onset and development of cancer. Consequently, the article conducted a sophisticated bioinformatics analysis to explore the potential connection between LM and GC.MethodsWe first undertook a differential analysis of the TCGA queue to recognize lipid metabolism-related genes (LRGs) that are differentially expressed. Subsequently, we utilized the LASSO and Cox regression analyses to create a predictive signature and validated it with the GSE15459 cohort. Furthermore, we examined somatic mutations, immune checkpoints, tumor immune dysfunction and exclusion (TIDE), and drug sensitivity analyses to forecast the signature’s immunotherapy responses.ResultsKaplan-Meier (K-M) curves exhibited considerably longer OS and PFS (p&lt;0.001) of the low-risk (LR) group. PCA analysis and ROC curves evaluated the model’s predictive efficacy. Additionally, GSEA analysis demonstrated that a multitude of carcinogenic and matrix-related pathways were much in the high-risk (HR) group. We then developed a nomogram to enhance its clinical practicality, and we quantitatively analyzed tumor-infiltrating immune cells (TIICs) using the CIBERSORT and ssGSEA algorithms. The low-risk group has a lower likelihood of immune escape and more effective in chemotherapy and immunotherapy. Eventually, we selected BCHE as a potential biomarker for further research and validated its expression. Next, we conducted a series of cell experiments (including CCK-8 assay, Colony formation assay, wound healing assay and Transwell assays) to prove the impact of BCHE on gastric cancer biological behavior.DiscussionOur research illustrated the possible consequences of lipid metabolism in GC, and we identified BCHE as a potential therapeutic target for GC. The LRG-based signature could independently forecast the outcome of GC patients and guide personalized therapy.
Evolution of guanylate binding protein genes shows a remarkable variability within bats (Chiroptera)
Authors: Pinheiro Ana , Borges J. Ricardo , Côrte-Real João Vasco , Esteves Pedro J. 
Published: January 2024

BackgroundGBPs (guanylate binding proteins), an evolutionary ancient protein family, play a key role in the host’s innate immune response against bacterial, parasitic and viral infections. In Humans, seven GBP genes have been described (GBP1-7). Despite the interest these proteins have received over the last years, evolutionary studies have only been performed in primates, Tupaia and rodents. These have shown a pattern of gene gain and loss in each family, indicative of the birth-and-death evolution process.ResultsIn this study, we analysed the evolution of this gene cluster in several bat species, belonging to the Yangochiroptera and Yinpterochiroptera sub-orders. Detailed analysis shows a conserved synteny and a gene expansion and loss history. Phylogenetic analysis showed that bats have GBPs 1,2 and 4-6. GBP2 has been lost in several bat families, being present only in Hipposideidae and Pteropodidae. GBPs1, 4 and 5 are present mostly as single-copy genes in all families but have suffered duplication events, particularly in Myotis myotis and Eptesicus fuscus. Most interestingly, we demonstrate that GBP6 duplicated in a Chiroptera ancestor species originating two genes, which we named GBP6a and GBP6b, with different subsequent evolutionary histories. GBP6a underwent several duplication events in all families while GBP6b is present as a single copy gene and has been lost in Pteropodidae, Miniopteridae and Desmodus rotundus, a Phyllostomidae. With 14 and 15 GBP genes, Myotis myotis and Eptesicus fuscus stand out as having far more copies than all other studied bat species. Antagonistically, Pteropodidae have the lowest number of GBP genes in bats.ConclusionBats are important reservoirs of viruses, many of which have become zoonotic diseases in the last decades. Further functional studies on bats GBPs will help elucidate their function, evolutionary history, and the role of bats as virus reservoirs.
ENHANCE: a comparative prospective longitudinal study of cognitive outcomes after 3 years of hearing aid use in older adults
Authors: Sarant Julia Z. , Busby Peter A. , Schembri Adrian J. , Fowler Christopher , Harris David C. 
Published: January 2024

BackgroundWith an aging population, the prevalence of hearing loss and dementia are increasing rapidly. Hearing loss is currently considered the largest potentially modifiable risk factor for dementia. The effect of hearing interventions on cognitive function should therefore be investigated, as if effective, these may be successfully implemented to modify cognitive outcomes for older adults with hearing loss.MethodsThis prospective longitudinal observational cohort study compared outcomes of a convenience sample of prospectively recruited first-time hearing aid users without dementia from an audiology center with those of community-living older adults participating in a large prospective longitudinal cohort study with/without hearing loss and/or hearing aids. All participants were assessed at baseline, 18 months, and 36 months using the same measures.ResultsParticipants were 160 audiology clinic patients (48.8% female patient; mean age 73.5 years) with mild–severe hearing loss, fitted with hearing aids at baseline, and 102 participants of the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging (AIBL) (55.9% female patient; mean age 74.5 years). 18- and 36-month outcomes of subsets of the first participants to reach these points and complete the cognition assessment to date are compared. Primary comparative analysis showed cognitive stability for the hearing aid group while the AIBL group declined on working memory, visual attention, and psychomotor function. There was a non-significant trend for decline in visual learning for the AIBL group versus no decline for the hearing aid group. The hearing aid group showed significant decline on only 1 subtest and at a significantly slower rate than for the AIBL participants (p &lt; 0.05). When education effects on cognitive trajectory were controlled, the HA group still performed significantly better on visual attention and psychomotor function (lower educated participants only) compared to the AIBL group but not on working memory or visual learning. Physical activity had no effect on cognitive performance trajectory.ConclusionHearing aid users demonstrated significantly better cognitive performance to 3 years post-fitting, suggesting that hearing intervention may delay cognitive decline/dementia onset in older adults. Further studies using appropriate measures of cognition, hearing, and device use, with longer follow-up, are required.