bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression and regulation of B7 family molecules on macrophages (MΦ) in preterm and term neonatal cord blood and peripheral blood of adults
Authors: Orlikowsky Thorsten W. , Spring Bärbel , Dannecker Günther E. , Niethammer Dietrich , Poets Christian F. , Hoffmann Michael K. 
Published: October 2004

AbstractBackgroundMacrophage (MΦ) receptors of the B7 family (CD80, CD86) play a crucial role in T cell activation: the lack of costimulation leads to anergy or apoptosis of reactive T cells. MΦ may differentiate into different subsets, the balance of which defines MΦ‐dependent T cell reactions. The aim of this study was to examine neonatal and adult T cell response with respect to the costimulatory MΦ‐potential in order to identify molecular predictors for the neonatal immune defense.MethodsMΦ from peripheral blood (PBMΦ) or cord blood (CBMΦ) were stimulated with interferon‐gamma (IFN‐γ), cyclic adenosine monophosphate (cAMP), CD40 ligand (CD40L), or αCD3.ResultsAs compared to PBMΦ, CBMΦ showed a significantly decreased upregulation of CD80 and/or CD86 after stimulation with IFN‐γ, cAMP, CD40L, and αCD3. Accordingly, the proliferative T cell response was impaired in the presence of CBMΦ. The fraction of T cells that underwent cell death was higher, and blast formation was significantly lower than that observed in the presence of PBMΦ.ConclusionsCBMΦ, as compared to PBMΦ, delivered fewer costimulatory but more cytotoxic signals to T cells. These observations suggest that MΦ are one factor explaining the suboptimal immune defense of neonates and their increased susceptibility to infection. Using the costimulatory MΦ‐potential as a predictor for immune responses requires a separate reference value system in neonatology. Cytometry Part B (Clin. Cytometry) 53B:40–47, 2003. © 2003 Wiley‐Liss, Inc.
Cytomics in predictive medicine
Authors: Valet Günter K. , Tárnok Attila 
Published: October 2004

AbstractPatient‐specific, disease‐course predictions with >95% or >99% accuracy during therapy would be highly valuable for everyday medicine. If these predictors were available, disease aggravation or progression, frequently accompanied by irreversible tissue damage or therapeutic side effects, could then potentially be avoided by early preventive therapy. The molecular analysis of heterogeneous cellular systems (cytomics) by cytometry in conjunction with pattern‐oriented bioinformatic analysis of the multiparametric cytometric and other data provides a promising approach to individualized or personalized medical treatment or disease management. As a consequence, better patient care and new forms of inductive scientific hypothesis development based on the interpretation of predictive data patterns are at reach. Cytometry Part B (Clin. Cytometry) 53B:1–3, 2003. © 2003 Wiley‐Liss, Inc.
FISH cytogenetics and prognosis in breast and non–small cell lung cancers
Authors: Massoner Anita , Augustin Florian , Duba Hans‐Christoph , Zojer Niklas , Fiegl Michael 
Published: October 2004

AbstractBackgroundInterphase cytogenetics by fluorescence in situ hybridization (FISH) has been demonstrated to be a valuable diagnostic tool in effusions from patients with solid tumors. As the next step, we investigated whether certain patterns of numeric aberrations in malignant effusion cells supply prognostic information.MethodsFrom a large series of effusions from patients with solid tumors, 55 effusions from breast cancer and 39 effusions from non–small cell lung cancer (NSCLC) were classified as malignant by cytology or FISH. Tumor cells were classified as FISH aneuploid for chromosome 11 and/or 17 or as not aneuploid. Predominant cytogenetic anomalies and patterns of intratumor cytogenetic heterogeneity were brought in relation to overall survival rate.ResultsThere was no difference with respect to overall survival rate when effusions with or without aneuploidy for chromosomes 11 and 17 were compared. Likewise, in effusions with aneuploidy, there was no difference in overall survival rate among patients with different modal chromosome copy numbers (e.g., trisomy vs. tetrasomy 11) or among patients with a low or high grade of intratumor complexity (defined by the intratumor heterogeneity of FISH aneuploidy). In breast cancer, aneuploidy with gain of chromosome 11 was associated with a significantly superior survival rate, suggesting that amplification of chromosome 11 DNA is associated with a less aggressive phenotype.ConclusionsSimple chromosomal changes as determined by FISH, such as gain of chromosome 11 copy numbers in breast cancer, may be prognostic. Prospective studies in primary tumors that classify distinct prognostic groups by FISH cytogenetics are warranted. © 2004 Wiley‐Liss, Inc.
Implication of bax in Xenopus laevis tail regression at metamorphosis
Authors: Sachs Laurent M. , Le Mevel Sébastien , Demeneix Barbara A. 
Published: October 2004

AbstractApoptosis is fundamental to normal vertebrate development. A dramatic example of postembryonic development involving apoptosis is tail regression during amphibian metamorphosis. Earlier studies led us to propose a functional role for the pro‐apoptotic protein Bax in tadpole tail regression. However, its physiological relevance has never been analyzed. We have now cloned a cDNA encoding Xenopus laevis bax (xlbax) and used in vivo gene transfer in tail muscle to analyze the effects of xlbax overexpression. Furthermore, by using an antisense strategy in a similar experimental paradigm, xlbax antisense mRNA was shown to block the apoptotic effects of xlbax and protect against apoptosis in metamorphosing tadpoles. Our results suggest that xlbax is a regulator of muscle fiber death in the regressing tail during metamorphosis. Developmental Dynamics 231:671–682, 2004. © 2004 Wiley‐Liss, Inc.
Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) expression during cardiac neural crest cell migration and its role in proMMP‐2 activation
Authors: Cantemir V. , Cai D.H. , Reedy M.V. , Brauer P.R. 
Published: October 2004

AbstractMatrix metalloproteinases (MMPs) are important mediators of neural crest (NC) cell migration. Here, we examine the distribution of tissue inhibitor of metalloproteinase (TIMP) ‐2 and TIMP‐3 and test whether manipulating TIMP levels alters chicken cardiac NC cell migration. TIMP‐2 mRNA is expressed at stage 11 in the neural epithelium and only in migrating cardiac NC cells. TIMP‐3 mRNA is expressed only in the notochord at stage 8 and later in the outflow tract myocardium. Exogenous TIMP‐2 increases NC motility in vitro at low concentrations but has no effect when concentrations are increased. In vitro, NC cells express membrane type‐1 matrix metalloproteinase (MT1‐MMP) and TIMP‐2 and they secrete and activate proMMP‐2. Antisense TIMP‐2 oligonucleotides block proMMP‐2 activation, decrease NC cell migration from explants, and perturb NC morphogenesis in ovo. Because TIMP‐2 is required for activation of proMMP‐2 by MT1‐MMP, this finding suggests TIMP‐2 expression by cardiac NC cells initiates proMMP‐2 activation important for their migration. Developmental Dynamics 231:709–719, 2004. © 2004 Wiley‐Liss, Inc.
Coexpression of Cux‐1 and notch signaling pathway components during kidney development
Authors: Sharma Madhulika , Fopma Amber , Brantley Jennifer G. , Vanden Heuvel Gregory B. 
Published: October 2004

AbstractCux‐1 is the murine homologue of the Drosophila gene cut, which is required for cellular differentiation in several tissues, including the wing margin and Malpighian tubule. Mammalian cut proteins function as cell cycle‐dependent transcriptional repressors in proliferating cells. Targets of Cux‐1 repression include the cyclin kinase inhibitors p21 and p27. However, little is known about the regulation of Cux‐1. In Drosophila, multiple genetic interactions between Cut and the Notch and Wingless signaling pathways occur during wing development. To begin to determine whether Cux‐1 regulation by the Notch signaling pathway is conserved in mammals, we compared the expression patterns of Cux‐1, the murine Notch receptors (Notch 1–4), and the murine ligands (Jagged 1, Jagged 2, and Delta 1) during murine embryogenesis and kidney development. In this report, we demonstrate that Cux‐1 expression overlaps with that of Notch signaling pathway components in multiple tissues during embryonic development. In the developing kidney, Cux‐1 expression overlaps with that of Notch pathway components in the condensing mesenchyme, in pretubular aggregates (comma and S‐shaped bodies), and in the presumptive podocytes of capillary loop stage glomeruli. Furthermore, Cux‐1 was significantly up‐regulated in the rat kidney epithelial cell line RKE expressing a constitutively active Notch 1, and this finding was associated with a reduction of p27. Moreover, Cux‐1 interacts with the Groucho homolog TLE‐4, a corepressor recruited by Notch effector proteins. Taken together, these results suggest that Cux‐1 may function in the context of the Notch signaling pathway in multiple tissues during mammalian embryogenesis. Developmental Dynamics 231:828–838, 2004. © 2004 Wiley‐Liss, Inc.
Hydrogen‐Bonded Network and Layered Supramolecular Structures Assembled from ClO4− Counterions with Unprecedented Monomeric [AgL2]+ and Chain Polymeric [AgL2]nn+ Complex Cations (L = Thioamide or Thiourea‐Like Ligands)
Authors: Sola Joan , López Alexandre , Coxall Robert A. , Clegg William 
Published: October 2004

AbstractThe complexes [Ag(etu)2]ClO4 (1) and [{Ag(py2tH)2}(ClO4)(H2O)0.5]n (2) have been obtained from the reactions of AgClO4 with the corresponding thioamide ligands (etu = imidazolidine‐2‐thione; py2tH = pyridine‐2‐thione). Complex 1, consisting of centrosymmetric monomeric [Ag(etu)2]+ cations and ClO4− counterions, constitutes the first bis[thio(mono‐ or di)amide] complex (M = Cu, Ag) known thus far to possess a linear MS2 mononuclear core. Component ions behave in the crystal structure as complementary partners, with all four N−H groups of each [Ag(etu)2]+ cation and all four oxygen atoms of each ClO4− anion involved in N−H···O−Cl hydrogen bonding associations. This leads to the assembly of a three‐dimensional supramolecular network. Complex 2, whose previously reported structure has been redetermined with higher precision, contains catena‐[Ag(py2tH)2]nn+ polymeric cations consisting of linear chains of linked Ag2(μ‐S)2 rings, with distorted tetrahedral AgS4 centres. Supramolecular association through N−H···O−Cl, N−H···O(water) and Cl−O···H−O−H···O−Cl hydrogen bonding, where all N−H groups and H2O molecules and only one or two oxygen atoms of each ClO4− anion are involved, leads to the formation of a two‐dimensional layered supramolecular structure. A correlation of some stereochemical parameters and a simple qualitative sulfur‐bridge bonding model has been developed for 2 and other related thioamide complexes containing M2(μ‐S)2 rings or M−S−M′ single bridges. For these structural units, suitable ranges of tilt and twist dihedral angles have been estimated and assigned to different bonding types. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Incorporation of a (Cyclopentadienyl)molybdenum Oxo Complex in MCM‐41 and Its Use as a Catalyst for Olefin Epoxidation
Authors: Abrantes Marta , Gago Sandra , Valente Anabela A. , Pillinger Martyn , Gonçalves Isabel S. , Santos Teresa M. , Rocha João , Romão Carlos C. 
Published: October 2004

AbstractThe tricarbonyl complex [(η5‐C5H4‐COOMe)Mo(CO)3Cl] was prepared from the reaction of sodium (methoxycarbonyl)cyclopentadienide, (C5H4‐CO2Me)Na, with (Bu4N)[Mo(CO)5I]. Heating the ester with 3‐(triethoxysilyl)propylamine gave the amide derivative {[η5‐C5H4‐CONH‐C3H6Si(OEt)3]Mo(CO)3Cl}. The functionalised tricarbonyl complex was immobilised in the ordered mesoporous silica MCM‐41 with a loading of 13 wt.‐% Mo (1.4 mmol·g−1) by carrying out a grafting reaction in dichloromethane. Powder X‐ray diffraction and nitrogen adsorption−desorption analysis indicated that the structural integrity of the support was preserved during the grafting and that the channels remained accessible, despite significant reductions in surface area, pore volume and pore size. The success of the coupling reaction was confirmed by 29Si and 13C (CP) MAS NMR spectroscopy. A supported dioxo complex of the type [(η5‐C5H4R)MoO2Cl] was subsequently prepared by oxidative decarbonylation of the tethered tricarbonyl complex using tert‐butyl hydroperoxide (TBHP). The oxidised material is an active catalyst for the liquid phase epoxidation of cyclooctene with TBHP as the oxygen source. Similar catalytic results were obtained using the tethered tricarbonyl complex directly as a pre‐catalyst since fast oxidative decarbonylation occurs under the reaction conditions used. For both systems, the desired epoxide was the only product and the initial activities were about 13 mol·molMo−1·h−1. The solid catalysts were recycled several times. Some activity was lost between the first and second runs but thereafter tended to stabilise. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Mono‐ and Dinuclear Rhenium Polyhydride Complexes Bearing the Chelating Ligand 1,2‐Bis(dicyclohexylphosphanyloxy)ethane
Authors: Bolaño Sandra , Bravo Jorge , García‐Fontán Soledad 
Published: October 2004

AbstractVariable‐temperature NMR spectroscopic studies of new rhenium polyhydride compounds of the type [ReH7(dcype)] (1), [Re2H8(dcype)2] (3) and [ReH5(dcype)L] (5a−f) [dcype = Cy2PO(CH2)2OPCy2; L = PPhn(OR)3−n, n = 0−2, R = Me, Et] show them to be highly fluxional classical hydride complexes. In the case of the ethoxy compounds 5b, 5d and 5f, three hydride interchange processes were observed in the temperature range 283−173 K and their activation parameters were determined by NMR line‐shape analysis. A mechanism is proposed for each. Protonation of 1 and 5 with HBF4·OMe2 gave the nonclassical hydrides [ReH8(dcype)]BF4 (2) and [ReH6(dcype)L]BF4 (6) which are relatively stable. Compound 2 decomposes at 273 K in solution releasing H2,whereas compound 6 can be stored at room temperature for more than 24 h without decomposition. Protonation of 3 with HBF4·OMe2 gave the classical dinuclear hydride [Re2H9(dcype)2]BF4. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Hydroalumination of Carbon Dioxide, Carbon Disulfide, and Phenyl Isocyanate with an Aluminum Ketiminate Compound
Authors: Kuo Pei‐Cheng , Chen I‐Chun , Chang Jr‐Chiuan , Lee Ming‐Tsung , Hu Chin‐Han , Hung Chen‐Hsiung , Lee Hon Man , Huang Jui‐Hsien 
Published: October 2004

AbstractThe reaction of MeC(O)C(H)=C(Me)NHAr (Ar = 2,6‐diisopropylphenyl) (1) with excess LiAlH4 in diethyl ether at −78 °C generates [AlH(OCMeCHCMeNAr)2] (2) in 76% yield. The aluminum formate compound [Al(OCMeCHCMeNAr)2(OCOH)] (3) can be isolated from the reaction of 2 with CO2 in 93% yield. Compound 3 is thermally stable and remains unchanged when heated under vacuum at 100 °C for 24 h. Similarly, a solution of 2 in dichloromethane reacts with carbon disulfide or phenyl isocyanate at room temperature to yield the insertion products [Al(OCMeCHCMeNAr)2(SCHS)] (4) and [Al(OCMeCHCMeNAr)2(OCH=NPh)] (5), respectively, in 80% and 92% yield. Reaction of 2 with 1 equiv. of urethane in toluene at refluxing temperature for 1 h yields the aluminum isocyanate compound [Al(OCMeCHCMeNAr)2(NCO)] (6). The molecular structures of compounds 2−6 have been determined by X‐ray crystallography. Density functional calculations show that the isomer of compound 2 with an N−N trans arrangement is 3.1 kcal·mol−1 lower in energy than the O−O trans isomer. Inserting CO2 into the Al−H bond of compound 2 results in the formation of the formate compound 3; this reaction is predicted to be exothermic by 29.8 kcal·mol−1. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Organic Phase PPO Biosensors Prepared by Multilayer Deposition of Enzyme and Alginate Through Avidin‐Biotin Interactions
Authors: Cosnier S. , Mousty C. , de Melo J. , Lepellec A. , Novoa A. , Polyak B. , Marks R. S. 
Published: October 2004

AbstractFilms of electrogenerated polypyrrole and hydrophilic alginate, both functionalized with biotin moieties, were used to allow for the transfer of polyphenol oxidase activity in organic media. Enzyme electrodes, based on multilayered structures, were protected at the molecular level by the affinity binding of alginate as a hydrophilic additive, and were then transferred into chlorobenzene, dichloromethane, chloroform, ethyl acetate or acetonitrile. The biosensor performance for the detection of catechol at −0.2 V was investigated, highlighting the main influence of the hydrophobicity of the solvent and, to a lesser extent, the dielectric constant. The effect of the substrate hydrophobicity on the biosensor response was examined in chlorobenzene.
On the Structure of PHB (=Poly[(R)‐3‐hydroxybutanoic Acid]) in Phospholipid Bilayers: Preparation of Trifluoromethyl‐Labeled Oligo[(R)‐3‐hydroxybutanoic Acid] Derivatives
Authors: Rueping Magnus , Albert Matthias , Seebach Dieter 
Published: October 2004

AbstractOligomers of (R)‐3‐hydroxybutanoate (OHB) have previously been shown to transport cations through lipid bilayers. The ion‐transport activity has been attributed to the formation of hydrophobic aggregates or pores, which have been identified by fluorescence‐microscopy measurements of membrane‐incorporated fluorescence‐labeled OHBs. To obtain more information about these aggregates, we describe here the synthesis of the specifically F‐labeled HB oligomers II–IV for structural investigation by means of solid‐state 19F‐NMR spectroscopic techniques.
Synthesis of 9‐Halogenated 9‐Deazaguanine N7‐(2′‐Deoxyribonucleosides)
Authors: Seela Frank , Shaikh Khalil I. , Wiglenda Thomas , Leonard Peter 
Published: October 2004

AbstractThe syntheses of N7‐glycosylated 9‐deazaguanine 1a as well as of its 9‐bromo and 9‐iodo derivatives 1b,c are described. The regioselective 9‐halogenation with N‐bromosuccinimide (NBS) and N‐iodosuccinimide (NIS) was accomplished at the protected nucleobase 4a (2‐{[(dimethylamino)methylidene]amino}‐3,5‐dihydro‐3‐[(pivaloyloxy)methyl]‐4H‐pyrrolo[3,2‐d]pyrimidin‐4‐one). Nucleobase‐anion glycosylation of 4a–c with 2‐deoxy‐3,5‐di‐O‐(p‐toluoyl)‐α‐D‐erythro‐pentofuranosyl chloride (5) furnished the fully protected intermediates 6a–c (Scheme 2). They were deprotected with 0.01M NaOMe yielding the sugar‐deprotected derivatives 8a–c (Scheme 3). At higher concentrations (0.1M NaOMe), also the pivaloyloxymethyl group was removed to give 7a–c, while conc. aq. NH3 solution furnished the nucleosides 1a–c. In D2O, the sugar conformation was always biased towards S (67–61%).
A New 2H‐Azirin‐3‐amine as a Synthon for α‐Methyl Glutamate
Authors: Hilty Florentine M. , Brun Kathrin A. , Heimgartner Heinz 
Published: October 2004

AbstractThe synthesis of a novel 2,2‐disubstituted 2H‐azirin‐3‐amine 10 as a building block for racemic Glu(2Me) is described. This synthon contains an ester group in the side chain. The reaction of 10 with thiobenzoic S‐acid and the amino acid Z‐Val‐OH yielded the racemic monothiodiamide 17 and the dipeptide 18 as a mixture of diastereoisomers, respectively (Scheme 2). From 18, each of the protecting groups was removed selectively (Scheme 3).
Molecular Structure, Vibrational Spectra, and Hydrogen Bonding of the Ionic Liquid 1‐Ethyl‐3‐methyl‐1H‐imidazolium Tetrafluoroborate
Authors: Katsyuba Sergey A. , Dyson Paul J. , Vandyukova Elena E. , Chernova Alla V. , Vidiš Ana 
Published: October 2004

AbstractThe IR and Raman spectra and conformations of the ionic liquid 1‐ethyl‐3‐methyl‐1H‐imidazolium tetrafluoroborate, [EMIM] [BF4] (6), were analyzed within the framework of scaled quantum mechanics (SQM). It was shown that SQM successfully reproduced the spectra of the ionic liquid. The computations revealed that normal modes of the EMIM+⋅BF$\rm{_{4}^{-}}$ ion pair closely resemble those of the isolated ions EMIM+ and BF$\rm{_{4}^{-}}$, except for the antisymmetric BF stretching vibrations of the anion, and the out‐of‐plane and stretching vibrations of the HC(2) moiety of the cation. The most plausible explanation for the pronounced changes of the latter vibrations upon ion‐pair formation is the H‐bonding between HC(2) and BF$\rm{_{4}^{-}}$. However, these weak H‐bonds are of minor importance compared with the Coulomb interactions between the ions that keep them closely associated even in dilute CD2Cl2 solutions. According to the ‘gas‐phase’ computations, in these associates, the BF$\rm{_{4}^{-}}$ anion is positioned over the imidazolium ring of the EMIM+ cation and has short contacts not only with the HC(2) of the latter, but also with a proton of the MeN(3) group.
Synthesis, Structure, and Spectroscopic and Electrochemical Properties of Heteroleptic Bis(phthalocyaninato) Rare Earth Complexes with a C4 Symmetry
Authors: Bian Yongzhong , Wang Rongming , Wang Daqi , Zhu Pehua , Li Renjie , Dou Jianmin , Liu Wei , Choi Chi‐Fung , Chan Hoi‐Shan , Ma Changqin , Ng Dennis K. P. , Jiang Jianzhuang 
Published: October 2004

AbstractA series of eleven heteroleptic bis(phthalocyaninato) rare earth double‐deckers [MIII(pc){pc(α‐OC5H11)4}] 1–11 (M=Y, SmLu; pc=phthalocyaninato; pc(α‐OC5H11)4=1,8,15,22‐tetrakis(1‐ethylpropoxy)phthalocyaninato) were prepared as racemic mixtures by [MIII(pc)(acac)]‐induced (acac=acetylacetonato) cyclic tetramerization of 3‐(1‐ethylpropoxy)phthalonitrile in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) in refluxing pentanol. These compounds could also be prepared by treating [MIII(pc)(acac)] with the metal‐free phthalocyanine H2{pc(α‐OC5H11)4} in refluxing octanol. The whole series of double‐decker complexes 1–11 were characterized by elemental analysis and various spectroscopic methods. The molecular structures of the Sm, Eu, and Er complexes 1, 2, and 8, respectively, were also determined by single‐crystal X‐ray diffraction analysis. The effects of the rare earth ion size on the reaction yield, molecular structure, and spectroscopic and electrochemical properties of these complexes were systematically examined.
Improved Protocol for the Three‐Component Biginelli Reactions and Biginelli‐Like Mannich Reactions of Carbamates, Aldehydes, and Ketones
Authors: Xu Li‐Wen , Wang Zong‐Ting , Xia Chun‐Gu , Li Lyi , Zhao Pei‐Qing 
Published: October 2004

AbstractA mild, convenient, and improved method for the direct three‐component Biginelli and Biginelli‐like Mannich‐type reactions of carbonyl compounds in the presence of inexpensive FeCl3⋅6 H2O and Me3SiCl as catalysts is described. Reactions performed with carbamates can be used to directly access N‐protected β‐amino carbonyl compounds in a single step.
Amber‐Woody Scent: Alcohols with Divergent Structure Present Common Olfactory Characteristics and Sharp Enantiomer Differentiation
Authors: Margot Christian , Simmons Dana P. , Reichlin Daniel , Skuy David 
Published: October 2004

AbstractOnly one out of the four possible trans isomers of the important perfumery alcohol Norlimbanol® (1) possesses a very strong amber‐woody smell, the isomer 1A with (1′R,3S,6′S) absolute configuration. Its enantiomer 1B is almost odorless and devoid of amber‐woody character, whereas the diastereoisomers 1C and 1D are considerably weaker and perceptible only by the most‐sensitive persons. The same is true for a whole series of perceptual analogs of 1, including β‐alkoxy alcohols. These ethers belong to two structural classes: [(2,2,6‐trimethylcyclohexyl)oxy]‐ (see 3, 4, and 16) or {[2‐(tert‐butyl)cyclohexyl]oxy}alkan‐2‐ol derivatives (see 19 and 20; Table). A superimposition model allowing for good overlap of the respective hydroxylated side chains offers a tentative explanation for the shared perceptual characteristics of the two classes (Fig. 5). The lipophilic cyclohexane moieties present only a minimal overlap in this model, suggesting that quite larger molecules might possess the same smell. (S)‐Configured β‐alkoxy alcohols can conveniently be obtained on a larger scale by enantioselective reduction of the corresponding ketones (Scheme 9).