bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemberdayaan Panti Asuhan Yatim Budi Mulya di Kabupaten Banyuwangi Melalui Budidaya Ikan Lele Dumbo Sistem Akuaponik
Authors: Lailatul Lutfiyah  , Rijal Fakrudin Permana  , Muhammad Novi Yusuf  
Published: October 2023

Panti asuhan merupakan suatu lembaga sosial untuk membentuk perkembangan anak-anak yang tidak memiliki keluarga atau tidak tinggal bersama keluarganya. Panti asuhan mempunyai tanggung jawab untuk memberikan pelayanan kesejahteraan sosial dan mental. Pada kenyataanya banyak panti asuhan yang masih terkendala terkait biaya operasional dalam melakukan pengembangan pembinaan anak-anak panti. Sistem akuaponik merupakan gabungan teknologi budi daya ikan dan tanaman dalam satu wadah. Budidaya ikan lele dumbo dengan sistem akuaponik merupakan solusi alternatif dalam menunjang kemandirian panti asuhan. Tujuan yang diharapkan dari kegiatan ini adalah adanya kegiatan usaha budidaya ikan di Panti Asuhan Yatim Budi Mulya Banyuwangi sehingga menjadikan kemandirian panti secara ekonomi semakin cepat terwujud. Fasilitas sistem akuaponik telah dibangun dan dihibahkan kepada mitra dan kemudian dilakukan kegiatan pengenalan sistem budidaya akuaponik terdiri dari cara pembuatan akuaponik dan komoditas yang dibudidayakan, sistem budidaya dan manajemen budidaya serta monitoring kegiatan budidaya. Metode sosialisasi dan diskusi dengan menggunakan daring platfom zoom. Evaluasi pelaksanaan program akuaponik dilakukan sebelum dan sesudah kegiatan. Data yang diperoleh kemudian disajikan dalam bentuk grafik serta dianalisis secara deskriptif. Kegiatan budidaya ikan lele dumbo sistem akuaponik dapat diaplikasikan pada lokasi mitra. Guna menunjang kemandirian panti asuhan,sehingga mampu mendapatkan penghasilan secara mandiri.
Peculiarities of the influence of natural factors on the functional state of the body of school-age children
Authors: Denysovets T. , Kvak O. 
Published: October 2023

This article reveals the essence and content of hardening procedures as the most effective methods of acclimatization and their impact on the functional state of the body of school-aged children. The need is outlined and the main approaches to the use of water procedures are outlined, which are an effective means of preventing colds and somatic diseases, a reliable means of preserving and strengthening health, and increasing work capacity.
A description of the physiological essence of hardening is given, which consists in the effect on the body of cooling, high temperature, and sunlight, as a result of which it recovers, improves health, and increases performance.
The use of water in the hardening system, which has a high heat capacity, was investigated. Of all the hardening factors, the procedures (cold washing, rubbing, wrapping, dousing, baths, gargling) are the most powerful and quick and normalize blood pressure and appetite, give a feeling of freshness, special lightness in the body and a good mood.
The need to apply systematic methods of hardening in educational institutions has been proved, and it has been found that the complex application of natural factors on the body of students allows to improve the functional state of school-age children, has a positive effect on the work of the cardiovascular and respiratory systems, the immune system, and the psycho-emotional state of children, contributes to the improvement the level of physical fitness and physical capacity of schoolchildren, improves well-being and mood.
An analysis of the effectiveness of the use of complex means of hardening with students of the 11th grade was carried out, where positive changes were noted, both in the group of girls and in the group of boys. It has been proven that the use of various hardening methods gives quite effective results. Children get sick less often, the body's resistance to infections increases.
The technique we developed consisted in the complex application of hardening means and recreational swimming. The procedures selected by us allow not only to improve the health of children, but also to raise the emotional background of the lesson. Improvement in general well-being and appetite, restful sleep, increased emotional tone, balanced mood, high mental and physical capacity, absence of colds, increased interest in life - these are indicators of the effectiveness of hardening procedures.
BARREIRAS QUE DIFICULTAM EMPRESAS DE PEQUENO PORTE DE IMPLANTAREM SISTEMAS ERP EM COMPARAÇÃO AS EMPRESAS DE GRANDEE PORTE
Authors: Coutinho Andre Isola , De Souza Leticia Costa 
Published: October 2023

O artigo buscou avaliar quais as barreiras enfrentadas por empresas de Pequeno Porte (EPP’s), na implantação de um sistema ERP (ERPs - Enterprise Resource Planning), e compará-las com as enfrentadas pelas empresas de Grande Porte. Seu principal objetivo é levantar e avaliar as causas mais comuns em ambos os portes, para que haja um estudo prévio e essas barreiras possam ser evitadas, mediante a gama de benefícios que esses tipos de sistemas agregam para as organizações. Para tanto, através de pesquisas exploratórias e descritivas foram realizados estudos, cujos resultados demonstraram que as principais barreiras encontradas em ambos os portes, estão relacionadas as mudanças e resistências enfrentadas pela cultura organizacional, e que a eficiência de uma implantação de sistemas ERP’s dependerá do seu nível do planejamento e não do porte da empresa, além de uma visão sistêmica de administração por parte dos gestores em entender a melhor maneira de gerir processos dentro deste objetivo.
ОСОБЛИВОСТІ ОЦІНЮВАННЯ НАВЧАЛЬНИХ ДОСЯГНЕНЬ МАЙБУТНІХ УЧИТЕЛІВ В УМОВАХ ДИСТАНЦІЙНОГО НАВЧАННЯ
Authors: РОМАНИШИНА Оксана , КАРАБІН Оксана , ГУРА Антоніна 
Published: October 2023

У статті розглянуто питання про можливості організації освітнього процесу, а саме контролю і оцінювання навчальних досягнень майбутніх учителів в умовах дистанційного навчання. Показано взаємозв’язок між оцінюванням в нормативних умовах і в умовах дистанційного навчання.
Подана характеристика кожного етапу оцінювання і контролю: вступний, проміжний і підсумковий. Вступний контроль проводиться шляхом тестування за матеріалами або шкільного підручника, або матеріалами попередньої спорідненої дисципліни. За одержаними балами визначається вступний рейтинг студента. Організація роботи за кредитно-модульною технологією дозволяє проводити оцінювати знання студентів за модулями. Для регулювання цього процесу розроблений графік проходження студентом модулів. У такому графіку є три лінії, позначення на яких відповідає ідеальному значенню оцінювання знань за кожним модулем з відміткою «задовільно», «добре» і «відмінно». Такі графіки є в кожного студента, що дає можливість самостійно регулювати своє навчання. Використання таких графіків є стимулом самостійності навчання. На проміжному етапі можна використати додаткові види контролю і оцінювання: взаємоконтроль і взаємо оцінювання, творчі завдання, які дозволяють проявити свій стиль міркування і рівень знань, написання листів ученим, розглядаючи їх теорії у власному баченні. Якщо студент бажає підвищити свій рейтинг, дозволяється перездача тем, але на протязі двох тижнів, оскільки матеріал наступного модуля базується на попередньому. На підсумковому контролі рейтинг виводиться за сумою балів за семестр.
Проведено аналіз ще однієї форми контролю і оцінювання: формувальне оцінювання. У завдання формувального оцінювання входить: встановлення взаємозв’язку між метою, завданнями, методологічними підходами, дидактичними принципами компонентами, критеріями, формами, методами і засобами освітнього процесу, різних типів технологій. Тобто, формувальне оцінювання забезпечує інформацію про ефективність освітнього процесу під впливом зовнішніх і внутрішніх факторів. Тобто, відбувається оцінювання дієвості педагогічної системи.
Quality, reliability, and content assessment of YouTube™ videos associated with aphasia
Authors: YAŞA İbrahim Can , MALKOÇ Gözde 
Published: October 2023

Aims: Health-related videos on YouTube make it easy to share information on diseases and address a wide audience. However, there is doubt among specialists about their reliability, quality, and whether they contain correct information. The present study aimed to evaluate the quality of the information provided by searching for “aphasia” on YouTube™.
Methods: The results of the YouTube™ search were examined using the keywords “aphasia, Broca, Wernicke, conductive type, transcortical, anomic”. A total of 100 videos were identified, containing at least one of the keywords, relevant to the context, having at least 1000 views, published after 2010, in the English language, and shorter than 60 minutes. Modified DISCERN, Global Quality Score (GQS), Video Information and Quality Index (VIQI), and the Journal of American Medical Association (JAMA), rating, viewer interaction, and meta data were used for evaluating the videos. The scores of the scales indicated by The Kruskal-Wallis H Test were compared between the groups according to the video source (news agency, healthcare personnel/specialist, other people). The data were analyzed with Dunn’s Test as a post-hoc test. Relational analyses and Spearman’s RHO Correlation were used for statistical analyzes. The significance level was taken as p
Evaluation of anxiety, psychological resilience and codependency in nurses during the COVID-19 pandemic
Authors: CANLI Derya 
Published: October 2023

Aims: In this study, it was aimed to evaluate anxiety levels in nurses during the COVID-19 pandemic and to examine the relationship between psychological resilience and codependency levels and anxiety levels.
Methods: The study was conducted on 152 nurses actively working in a pandemic hospital during the COVID-19 outbreak. Sociodemographic Information Form, Beck Anxiety Inventory, Spann-Fischer Codependency Scale, Brief Resilience Scale were used as data collection tools.
Results: As a result of the study, anxiety and codependency scores of nurses working in high-risk pandemic units during the pandemic were higher and psychological resilience scores were lower than those working in low-risk units. When the relationship between anxiety, psychological resilience and codependency in the research group was examined; a negative and highly significant relation was found between psychological resilience and anxiety and between psychological resilience and codependency, and a positive and highly significant relation was found between anxiety and codependency (p
Effect of biostimulant raw materials on soybean (Glycine max) crop, when applied alone or in combination with herbicides
Authors: Franzoni Giulia , Bulgari Roberta , Florio Francesco Elia , Gozio Enrico , Villa Daniele , Cocetta Giacomo , Ferrante Antonio 
Published: October 2023

IntroductionBiostimulants exert positive functions in plants, improving yield and quality, and alleviating the negative effects of abiotic stresses. Among them, the application of herbicides may cause damage to nontarget plants. At present, limited information is available regarding the interaction between biostimulants and herbicides.MethodsThe purpose of the present study was to assess the effect of an herbicide’s mixture (Harmony® 50 SX® + Tuareg® + Zetrola®), used in combination with several biostimulant raw materials (BRM), on the agronomic and physiologic characteristics of soybean. The experiments were conducted in two seasons, 2020 and 2021, applying the herbicides mixture alone or associated with 10 BRM.ResultsDifferences emerged between the two years, considering nitrate, total sugars concentration, flavonol, and chlorophyll a fluorescence-related parameters. Chlorophyll content significantly declined (−45% in 2020) in plants treated with the herbicides mixture alone but, in combination with potassium silicate, the chlorophyll values were restored to control levels. The same positive effect observed in response to the combination of potassium silicate and the herbicide mixture has been confirmed in the second year of experiment. At the same time, chlorophyll content and Nitrogen Index were positively increased (up to 8% and 30%, respectively) depending on the application of some BRM and the year. A significant effect of biostimulants on yield was confirmed by the application of Ascophyllum nodosum (+16%) and humic acids (+7%), in 2020. However, the combined use with the herbicides nullifies the increase. DiscussionThe results obtained from these experiments support the use of biostimulants in improving specific quality traits (chlorophyll content, leaves nitrogen status, and secondary metabolites accumulation). At the same time, the potential use of biostimulants in combination with herbicides needs to be further explored since of external factors (environment, year…) still have a strong effect on their efficacy.
Developmental, cytogenetic and epigenetic consequences of removing complex proteins and adding melatonin during in vitro maturation of bovine oocytes
Authors: Tutt Desmond A. R. , Guven-Ates Gizem , Kwong Wing Yee , Simmons Rob , Sang Fei , Silvestri Giuseppe , Canedo-Ribeiro Carla , Handyside Alan H. , Labrecque Remi , Sirard Marc-André , Emes Richard D. , Griffin Darren K. , Sinclair Kevin D. 
Published: October 2023

BackgroundIn vitro maturation (IVM) of germinal vesicle intact oocytes prior to in vitro fertilization (IVF) is practiced widely in animals. In human assisted reproduction it is generally reserved for fertility preservation or where ovarian stimulation is contraindicated. Standard practice incorporates complex proteins (CP), in the form of serum and/or albumin, into IVM media to mimic the ovarian follicle environment. However, the undefined nature of CP, together with batch variation and ethical concerns regarding their origin, necessitate the development of more defined formulations. A known component of follicular fluid, melatonin, has multifaceted roles including that of a metabolic regulator and antioxidant. In certain circumstances it can enhance oocyte maturation. At this stage in development, the germinal-vesicle intact oocyte is prone to aneuploidy and epigenetic dysregulation.ObjectivesTo determine the developmental, cytogenetic and epigenetic consequences of removing CP and including melatonin during bovine IVM.Materials and methodsThe study comprised a 2 x 2 factorial arrangement comparing (i) the inclusion or exclusion of CP, and (ii) the addition (100 nM) or omission of melatonin, during IVM. Cumulus-oocyte complexes (COCs) were retrieved from stimulated cycles. Following IVM and IVF, putative zygotes were cultured to Day 8 in standard media. RNAseq was performed on isolated cumulus cells, cytogenetic analyses (SNP-based algorithms) on isolated trophectoderm cells, and DNA methylation analysis (reduced representation bisulfite sequencing) on isolated cells of the inner-cell mass.ResultsRemoval of CP during IVM led to modest reductions in blastocyst development, whilst added melatonin was beneficial in the presence but detrimental in the absence of CP. The composition of IVM media did not affect the nature or incidence of chromosomal abnormalities but cumulus-cell transcript expression indicated altered metabolism (primarily lipid) in COCs. These effects preceded the establishment of distinct metabolic and epigenetic signatures several days later in expanded and hatching blastocysts.ConclusionsThese findings highlight the importance of lipid, particularly sterol, metabolism by the COC during IVM. They lay the foundation for future studies that seek to develop chemically defined systems of IVM for the generation of transferrable embryos that are both cytogenetically and epigenetically normal.
Protection from infection and reinfection due to the Omicron BA.1 variant in care homes
Authors: Choudhry Saher , Rowland Thomas A. J. , McClelland Kamil , Renz Erik , Iyanger Nalini , Chow J Yimmy , Aiano Felicity , Ladhani Shamez N. , Jeffery-Smith Anna , Andrews Nick J. , Zambon Maria 
Published: October 2023

IntroductionFollowing the emergence of SARS-CoV-2 in 2020, care homes were disproportionately impacted by high mortality and morbidity of vulnerable elderly residents. Non-pharmaceutical interventions (NPIs) and improved infection control measures together with vaccination campaigns have since improved outcomes of infection. We studied the utility of past infection status, recent vaccination and anti-S antibody titres as possible correlates of protection against a newly emergent Omicron variant infection.MethodsProspective longitudinal surveillance of nine sentinel London care homes from April 2020 onwards found that all experienced COVID-19 outbreaks due to Omicron (BA.1) during December 2021 and January 2022, despite extensive prior SARS-CoV-2 exposure and high COVID-19 vaccination rates, including booster vaccines (&gt;70% residents, &gt;40% staff).ResultsDetailed investigation showed that 46% (133/288) of Omicron BA.1 infections were SARS-CoV-2 reinfections. Two and three COVID-19 vaccine doses were protective against Omicron infection within 2-9 weeks of vaccination, though protection waned from 10 weeks post-vaccination. Prior infection provided additional protection in vaccinated individuals, approximately halving the risk of SARS-CoV-2 infection.DiscussionAnti-S antibody titre showed a dose-dependent protective effect but did not fully account for the protection provided by vaccination or past infection, indicating that other mechanisms of protection are also involved.
The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome
Authors: Marín-Prida Javier , Rodríguez-Ulloa Arielis , Besada Vladimir , Llopiz-Arzuaga Alexey , Batista Nathália Vieira , Hernández-González Ignacio , Pavón-Fuentes Nancy , Marciano Vieira Érica Leandro , Falcón-Cama Viviana , Acosta Emilio F. , Martínez-Donato Gillian , Cervantes-Llanos Majel , Lingfeng Dai , González Luis J. , Fernández-Massó Julio Raúl , Guillén-Nieto Gerardo , Pentón-Arias Eduardo , Amaral Flávio Almeida , Teixeira Mauro Martins , Pentón-Rol Giselle 
Published: October 2023

IntroductionThe antinociceptive and pharmacological activities of C-Phycocyanin (C-PC) and Phycocyanobilin (PCB) in the context of inflammatory arthritis remain unexplored so far. In the present study, we aimed to assess the protective actions of these compounds in an experimental mice model that replicates key aspects of human rheumatoid arthritis.MethodsAntigen-induced arthritis (AIA) was established by intradermal injection of methylated bovine serum albumin in C57BL/6 mice, and one hour before the antigen challenge, either C-PC (2, 4, or 8 mg/kg) or PCB (0.1 or 1 mg/kg) were administered intraperitoneally. Proteome profiling was also conducted on glutamate-exposed SH-SY5Y neuronal cells to evaluate the PCB impact on this key signaling pathway associated with nociceptive neuronal sensitization.Results and discussionC-PC and PCB notably ameliorated hypernociception, synovial neutrophil infiltration, myeloperoxidase activity, and the periarticular cytokine concentration of IFN-γ, TNF-α, IL-17A, and IL-4 dose-dependently in AIA mice. In addition, 1 mg/kg PCB downregulated the gene expression for T-bet, RORγ, and IFN-γ in the popliteal lymph nodes, accompanied by a significant reduction in the pathological arthritic index of AIA mice. Noteworthy, neuronal proteome analysis revealed that PCB modulated biological processes such as pain, inflammation, and glutamatergic transmission, all of which are involved in arthritic pathology.ConclusionsThese findings demonstrate the remarkable efficacy of PCB in alleviating the nociception and inflammation in the AIA mice model and shed new light on mechanisms underlying the PCB modulation of the neuronal proteome. This research work opens a new avenue to explore the translational potential of PCB in developing a therapeutic strategy for inflammation and pain in rheumatoid arthritis.
A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases
Authors: Mangoni Arduino A. , Zinellu Angelo 
Published: October 2023

There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation. We sought to address the link between this pathway and the presence rheumatic diseases (RD) by conducting a systematic review and meta-analysis of studies reporting the plasma or serum concentrations of tryptophan, kynurenine, and other relevant metabolites in RD patients and healthy controls. We searched electronic databases for relevant articles published between inception and the 30th of June 2023. Risk of bias and certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and the Grades of Recommendation, Assessment, Development and Evaluation Working Group system. In 24 studies selected for analysis, compared to controls, RD patients had significantly lower tryptophan (standard mean difference, SMD= -0.71, 95% CI -1.03 to -0.39, p&lt;0.001; I2 = 93.6%, p&lt;0.001; low certainty of evidence), and higher kynurenine (SMD=0.69, 95% CI 0.35 to 1.02, p&lt;0.001; I2 = 93.2%, p&lt;0.001; low certainty), kynurenine to tryptophan ratios (SMD=0.88, 95% CI 0.55 to 1.21, p&lt;0.001; I2 = 92.9%, p&lt;0.001; moderate certainty), 3-hydroxykynurenine (SMD=0.74, 95% CI 0.30 to 1.18, p=0.001; I2 = 87.7%, p&lt;0.001; extremely low certainty), and quinolinic acid concentrations (SMD=0.71, 95% CI 0.31 to 1.11, p&lt;0.001; I2 = 88.1%, p&lt;0.001; extremely low certainty). By contrast, there were non-significant between-group differences in kynurenic acid, 3-hydroxyanthranilic acid, kynurenic acid to kynurenine ratio, or quinolinic acid to kynurenine acid ratio. In meta-regression, the SMD of tryptophan, kynurenine, and kynurenine to tryptophan ratio were not associated with age, publication year, sample size, RD duration, C-reactive protein, or use of anti-rheumatic drugs and corticosteroids. In subgroup analysis, the SMD of tryptophan, kynurenine, and kynurenine to tryptophan ratio was significant across different types of RD, barring rheumatoid arthritis. Therefore, we have observed significant alterations in tryptophan, kynurenine, 3-hydroxykynurenine, and quinolinic acid concentrations in RD patients. Further research is warranted to determine whether these biomarkers can be useful for diagnosis and management in this patient group. (PROSPERO registration number: CRD CRD42023443718).Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD CRD42023443718.