bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization of 1.25mm wire and locking plate fixation for a comminuted low transverse distal humerus fracture, a case report of a 78-year-old woman.
Authors: McDermott Michael R , Mufarreh Naem A , Handal Brian A , Gao Sean L , Bamberger H. Brent 
Published: October 2023

Introduction Low transverse distal humerus fractures can be challenging to treat in elderly populations—especially when there is severe comminution or underlying bone demineralization. Current operative interventions include total elbow arthroplasty or open reduction internal fixation (ORIF) with traditional plate and screw fixation. Herein, we present a unique case utilizing Kirschner wires (K-wires) and locking plate fixation as an alternative approach to managing low transverse distal humerus fractures. Case A 78-year-old right-hand dominant retired female presented with a displaced, comminuted, low transverse distal humerus fracture secondary to a fall from standing. Fixation of this fracture was achieved through a slight modification of the skinny K-wire and locking plate technique described by Olson et al. in 2021. Methods A triceps-sparing approach to the distal humerus was conducted through a direct posterior incision. The low transverse extra-articular fracture was identified and anatomically reduced. A posterior medial distal humerus plate was secured to reduce the medial column with 1.25x150mm K-wires subsequently placed through the trochlea. The K-wires were then bent as they exited the lateral side and cut short in the metaphysis, approximately 90° to the shaft of the humerus. After which, a posterolateral distal humerus plate was used to secure the lateral epicondyle and secures the K-wires beneath it. Results Seven weeks after the procedure, the patient had regained 81% elbow arc of motion, with a complete return of grip strength, pronation, and supination. At this time, radiographs demonstrated satisfactory bone healing, and the patient surpassed all therapy goals. Conclusion Our case demonstrates the modified use of the 1.25mm K-wire and locking plate technique as a satisfactory treatment option for comminuted low transverse distal humerus fracture in a 78-year-old female who sustained a ground-level fall. Ultimately resulting in the rapid return of function by postoperative week seven.
Pendampingan Pembelajaran Bahasa Inggris kepada Siswa Kelas VI MI Mambaul Ulum Banjarejo Pagelaran Malang
Authors: Mulis Mulis 
Published: October 2023

This English learning assistance was carried out at MI Mambaul Ulum Banjarejo because at that school English was not practiced (not included in the curriculum) as a general lesson or Mulok. The purpose of this English learning assistance is to provide basic knowledge of English. The learning assistance method used is drilling. In this mentoring activity, there are two skills tests as evaluation material, namely in the middle of the mentoring implementation and at the end of the mentoring meeting. In the end, it was found that based on the scores obtained in the final test of the material presented, there were differences in mastery of the basic material in English; low, fair, and medium
The specifics of cognitive and behavioral responses to therapy of the patients with borderline personality disorder: overview of foreign studies
Authors: Zvonov Petr Anatol'evich 
Published: October 2023

The study of diagnostic methods and the development of methods for the treatment of personality disorders is a significant scientific task. Personality disorders, including borderline personality disorder, characterized by hypertrophied emotions and a violation of self-identification, are painful for both patients and their loved ones. The article analyzes the results of a number of studies and observations in the field of experience of the treatment of borderline personality disorder. Cognitive and behavioral responses to therapy of the patients with borderline personality disorder are considered, as well as the features of building a therapeutic alliance, the formation of epistemological trust of the patient to the therapist, resistance to therapy and early dropout. Based on the analysis of a number of studies, it was found that patients with borderline personality disorder are in dire need of psychotherapy, believe that the therapist is the person who can solve all their problems, often transfer responsibility for their condition on him, forming a kind of child–parent relationship. Because of this, patients with borderline personality disorder often violate the therapist's personal boundaries, demanding his availability at any time. Such patients may perceive therapy as the only safe environment. At the same time, due to the fear of rejection, the formation of a therapeutic alliance takes a long time.
Covid Impact on Children's Education: A Case Study of Punjab, India
Authors: Kaur Atinder Pal , Romana G. S. , Vatta Kamal 
Published: October 2023

Covid-19 has had an unforgettable effect on the world and disrupted the whole of society. It has a major effect on the health system of the society which disrupts the economic system as well. Resulting in a disruption in the normal life of the people. Sudden lockdowns and restrictions on mobility have made sudden changes in the society. To curb the spread of COVID-19, social distancing and lockdown also followed in India. This causes a serious effect on the education system as shuts down all schools, colleges, and universities. The new system of online education was initiated to tackle the situation. Thus, the present study has a main objective to understand the problems and challenges faced by parents and children with this new norm. For this, the data was collected from 100 households through a semi-structured interview schedule from the Bathinda district of Punjab. The study found that there was a shift of schools from private to government after the lockdown because of shutdown of the economic sector. Various parents faced economic crises and low wages that caused non-affordability of school fees and other expenditures. Parents faced serious setbacks and disruptions in their daily routines also. Similarly, children have become addicted to phones and the internet. Children started watching YouTube and cartoons that hampered their education.
Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population
Authors: Oyewole Oyedeji Samuel , Adeleke Adesina Adeyemi , Taiwo Oke Olusegun , Ganiyu Adeosun Oyebola , Kunle Awe 
Published: October 2023

Objectives: This study investigated levels of measured parameters; bio-elements (zinc, copper, selenium, chromium, and manganese), heavy metals (cadmium and lead), oxidative stress biomarkers (vitamin C, Vitamin E, reduced Glutathione-GSH and malondialdehyde-MDA) and lipid profile (cholesterol-CHOL, triglyceride- TG, high-density lipoprotein- HDL, low-density lipoprotein- LDL and VLDL) in primary hypertensive individuals.
Materials and Methods: A total of 74 confirmed hypertensive individuals (30 males, 44 females) of 30-55 years (test subjects) and 46 (22males, 24 females) age-matched apparently healthy normotensive individuals (control) were involved in this study. Atomic absorption spectrophotometer was used to determine the concentrations of bio-elements and toxic metals while spectrophotometric methods were used for the concentrations of oxidative stress biomarkers and lipid fractions.
Results: Comparative analysis between test and control subjects showed significantly reduced concentrations of vitamins C and E, GSH, the bio-elements, HDL and Zinc/Copper ratio. Significantly elevated concentrations of the toxic metals, MDA, CHOL, TG, LDL, and VLDL, the atherogenic indices- LDL/HDL, TC/HDL, and TG/HDL as well as Cadmium/ Zinc ratio. There was indirect association between the bio-elements and atherogenic lipid fractions but a direct correlation with HDL. Also, negative correlations were observed between the heavy metals and the antioxidants biomolecules.
Conclusion: The concentrations of the measured bio-elements, vitamins C and E, GSH and HDL were significantly lower in hypertensive individuals while the levels of heavy metals, cholesterol, TG, LDL and MDA were significantly higher.
Effect of Foliar Application of Different Chemicals on Yield and Yield Attributes of Black gram [Vigna mungo (L.) Hepper] under Rainfed Condition
Authors: Pandey Vaibhav , Singh Harendra , Kumar Purushottam , Dwivedi D. K. , Mishra Abhishek , Singh Digvijay , Mishra Suraj , Singh Ankit 
Published: October 2023

A field experiment was performed at the “TCA., research farm of Dholi (Muzaffarpur), which is a unit of the Dr. Rajendra Prasad Central Agricultural University, Pusa (Samastipur), Bihar, during the Kharif season of 2021” to investigate the “Effect of foliar application of different chemicals on yield attributes and yield of Black gram [Vigna mungo (L.) Hepper] under rainfed condition”. The design used for making layout of experimental unit was RBD, that was replicated three times, with ten treatments in each replication for a total of 30 plots. The experiment conducted with 10 treatments viz., Absolute Control (T1), Water Spray (T2), ZnSO4 @ 0.5% Spray (T3), NPK (19-19-19) @ 2% Spray (T4), Urea @ 2% Spray (T5), DAP @ 2% Spray (T6), Salicylic acid @ 100 ppm Spray (T7), Potassium Nitrate @ 2% Spray (T8), Boron 0.25 % Spray (T9), Potassium Chloride @ 0.2% Spray(T10). The foliar spray of different treatments applied had a significant impact on the number of pod number plant-1, seed count pod-1 and the length of the pod. However, foliar chemicals had no appreciable impact on the weight of 100 seeds. At pre-flowering and pod-initiation stage, foliar treatment of “NPK (19-19-19) @ 2 % spray (T4)” resulted in significantly greater seed production and stover output. Different chemical administration to the foliage had no significant effect on harvest index.
Biofabrication of Heterogeneous, Multi‐Layered, and Human‐Scale Tissue Transplants Using Eluting Mold Casting
Authors: Tosoratti Enrico , Rütsche Dominic , Asadikorayem Maryam , Ponta Simone , Fisch Philipp , Flégeau Killian , Linder Thomas , Guillon Pierre , Zenobi‐Wong Marcy 
Published: October 2023

AbstractThe creation of multi‐tissue auricular transplants for the treatment of microtia is a challenge due to the complex and layered structure of this anatomical tissue. A novel casting technique for the 3D biofabrication of heterogeneous, multi‐layered, and human‐scale tissue transplants using eluting agarose molds is presented. The molds are generated by casting agarose into custom 3D‐printed containers, termed metamolds, optimized to facilitate the hydrogel casting process based on geometric and topological constraints. Casting yields high resolution (50 µm) and allows for subsequent casting of further hydrogel layers on the transplant. Multi‐layered auricular constructs are fabricated on a cartilage core consisting of a hyaluronic acid‐alginate double network and an adjacent gelatin‐based dermal layer. Bonding between adjacent layers is achieved by orthogonal physical and enzymatic crosslinking of residual functional groups between each layer. Material composition and culture duration are optimized for each layer allowing for maturation into cartilaginous and pre‐vascularized dermal tissues. To demonstrate the scalability of this technique for the biofabrication of human‐sized transplants, bi‐layered human‐sized ears are cast. Overall, this novel casting technique offers a promising approach for the fabrication of complex tissue grafts, overcoming the limitations of other traditional biofabrication methods.
Magnetic Field‐Directed Deep Thermal Therapy via Double‐Layered Microneedle Patch for Promoting Tissue Regeneration in Infected Diabetic Skin Wounds
Authors: He Dengfeng , Liu Xingmou , Jia Jiezhi , Peng Bo , Xu Na , Zhang Qing , Wang Shang , Li Lei , Liu Menglong , Huang Yong , Zhang Xiaorong , Yu Yunlong , Luo Gaoxing 
Published: October 2023

AbstractAlthough near‐infrared (NIR) light‐based photothermal therapies have shown therapeutic potential for infected wounds, the attenuation of NIR light intensity in tissue has severely limited the usage in deep bacterial infections. Herein, magneto‐thermal responsive bilayer microneedles (Fe‐Se‐HA MNs) consisting of functionalized hyaluronic acid (HA), ferro‐ferric oxide (Fe3O4), and micelle‐protected selenium nanoparticles (SeNPs@LAS) are constructed to overcome this challenge based on a self‐designed disk‐shaped electromagnetic field device (Disk‐ZVS). The electromagnetic field generated by the Disk‐ZVS shows virtually no intensity attenuation in living tissue. Finite element simulations showed that the field intensity and electromagnetic loss are concentrated on the tips of Fe‐Se‐HA MNs. The MNs are able to puncture hard scabs, penetrate into bacterial biofilms, and perform effective magnetic‐thermal conversion for deep hyperthermia sterilization. Following, the Fe‐Se‐HA MNs can be gradually degraded by excessive hyaluronidase in diabetic wound to release SeNPs, which reduce reactive oxygen species (ROS) to regulate wound redox homeostasis. Meanwhile, the SeNPs are beneficial to angiogenesis, which facilitates blood vessel formation and promotes wound repair. Therefore, various functions can be achieved for the Fe‐Se‐HA MNs, such as magneto‐thermal disinfection, deep and non‐invasive tissue penetration, anti‐inflammation, and pro‐angiogenesis, which shows great potential as an adjunctive therapy for infected diabetic wounds.
A One‐Pot Three‐In‐One Synthetic Strategy to Immobilize Cobalt Corroles on Carbon Nanotubes for Oxygen Electrocatalysis
Authors: Li Xialiang , Qin Haonan , Han Jinxiu , Jin Xiaotong , Xu Yuhan , Yang Shujiao , Zhang Wei , Cao Rui 
Published: October 2023

AbstractMolecular electrocatalysis requires the immobilization of molecular catalysts on electrode materials for practical uses. Direct adsorption of catalyst molecules on electrode materials is simple, but grafting molecules through chemical bonds can significantly improve electrocatalytic efficiency and durability. However, designing and synthesizing catalyst molecules to simultaneously improve catalytic activities and realize easy grafting on electrodes is challenging. The study herein reports on a one‐pot strategy to graft Co corroles on pyridine‐modified carbon nanotubes (CNTs) for oxygen electrocatalysis. By modifying CNTs with pyridines, the resulting pyridine‐modified CNTs can function as platforms to grab in situ generated Co corroles through the axial pyridine ligation on Co. Such an immobilization strategy combines three effects for the regulation of electrocatalysis, including the axial ligand effect, the electron transfer effect, and the chemical bond effect. The resulting hybrid materials show high efficiency for oxygen electrocatalysis, and the Zn–air battery assembled using these materials displays comparable performance as the Pt/Ir‐based battery. Moreover, the electrocatalytic efficiency of these hybrid materials can be systematically tuned by using different pyridines, highlighting the controllable feature of this strategy. Therefore, this work is significant to present a one‐pot three‐in‐one strategy to immobilize catalyst molecules on CNTs for electrocatalysis.
Directional and Reconfigurable Assembly of Active Colloidal Motors Triggered by Chemical Communications
Authors: Huang Yang , Lin Zhihua , He Qiang 
Published: October 2023

AbstractAnisotropic colloidal particles can directionally self‐assemble, but the resulting assemblies cannot reconfigure unless the surface properties of colloidal particles change. Although external fields with adjustable inputs can guide the reconstruction of active structures after stimulating the dynamic assembly of active colloidal motors, the interaction between colloidal motors is unclear. Here, the study reports a bioinspired communication and directed assembly of peanut‐shaped colloidal motors with the emergence of ordered ribbon structures triggered by self‐generated chemical fields. The colloidal motors photocatalytically decompose the fuel to create the chemical concentration gradient fields and exert long‐range attractions on the colloidal scale, which enable colloidal motors to communicate by sensing each other, synchronizing orientation, and assembling side‐by‐side after the collision between their local flow fields. The inter‐individual communication occurs at a critical distance of ≈4.4 µm, resulting from the interplay between hydrodynamic effects, long‐ranged phoretic attraction, and short‐ranged magnetic interaction. The linear ribbons are still active owing to the symmetry breaking of the local fluid field and can be switched between rigid and flexible states according to light conditions to simulate the polymer conformation. The complexity of colloidal motors can be combined with external manipulations to manufacture active soft materials with precise and adaptive functions.
Construction and Mechanism of IL‐15‐Based Coactivated Polymeric Micelles for NK Cell Immunotherapy
Authors: Shao Dongyan , Bai Ting , Zhu Bobo , Guo Xiaojia , Dong Kai , Shi Junling , Huang Qingsheng , Kong Jie 
Published: October 2023

AbstractNatural killer (NK) cells are an important contributor to cancer immunotherapy, but their antitumor efficacy remains suboptimal. While cytokine‐based priming shows promise in enhancing NK‐cell activity, its clinical translation faces many challenges, including coactivation of multiple cytokines, poor pharmacokinetics, and limited mechanistic understanding. Here, this work develops a polymeric micelle‐based IL‐15/IL‐2 codelivery system (IL‐15/2‐PEG‐PTMC) for NK‐cell activation. In vivo studies demonstrate that half‐life of IL‐15 and IL‐2 and the recruitment of NK cell within tumor tissue are significantly increased after PEG‐PTMC loading. Coupled with the coactivation effect of IL‐15 and IL‐2 conferred by this system, it noticeably delays the growth of tumors compared to conventional NK‐cell activation approach, that is free IL‐15 and IL‐2. It is also surprisingly found that cholesterol metabolism is highly involved in the NK cell activation by IL‐15/2‐PEG‐PTMC. Following stimulation with IL‐15/2‐PEG‐PTMC or IL‐15, NK cells undergo a series of cholesterol metabolism reprogramming, which elevates the cholesterol levels on NK cell membrane. This in turn promotes the formation of lipid rafts and activates immune synapses, effectively contributing to the enhancement of NK cell's antitumor activity. It is believed that it will open a new avenue for improving the efficacy of NK cell immunotherapy by regulating cholesterol metabolism.
Chiroptical Switching of Electrochromic Polymer Thin Films
Authors: Song Inho , You Liyan , Chen Ke , Lee Won‐June , Mei Jianguo 
Published: October 2023

AbstractThe interaction between light and chiroptical polymers plays a crucial role in chiroptics, spintronics, and chiral‐spin selectivity. Despite considerable successes in creating dissymmetric polymer films, the elucidation of chiroptical activities under electrochemical switching remains unexplored. Here homogeneous chiral electrochromics is reported using chiral assembly of conjugated polymers through a transient solidification process with molecular chiral templates. In their neutral state, the chiral electrochromic polymers directly produce a remarkably dissymmetric polarization‐dependent transmittance. The circular dichroism (CD) and dissymmetric transmission can be tuned by adjusting the doping level of the electrochemically active polymer films. Under high levels of oxidation, the chiroptical activities are reversed with strong bleaching in the visible, leading to formation of monosignate CD spectra over the infrared region. The matching between circular polarization handedness and chirality of chiroptical polymers makes a distinct impact on optical contrast and color switching dynamics due to the flipped chiroptical activities through polymer redox reactions. The differential circularly polarized transmission in the chiral see‐through display can make a well‐resolved color change in human eyes, demonstrating proof‐of‐concept devices for 3D imaging and information encryption. This work serves as a foundation to develop advanced on‐chip fabrication of circular polarization‐multiplexed display in flexible and highly integrated platforms.
Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review
Authors: Ebrahimi Aliakbar , Icoz Kutay , Didarian Reza , Shih Chih‐Hsin , Tarim E. Alperay , Nasseri Behzad , Akpek Ali , Cecen Berivan , Bal‐Ozturk Ayca , Güleç Kadri , Li Yi‐Chen Ethan , Shih Steven , Sirma Tarim Burcu , Tekin H. Cumhur , Alarçin Emine , Tayybi‐Azar Mehdi , Ghorbanpoor Hamed , Özel Ceren , Eker Sarıboyacı Ayla , Dogan Guzel Fatma , Bassous Nicole , Shin Su Ryon , Avci Huseyin 
Published: October 2023

AbstractSeparation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab‐on‐a‐chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic‐based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab‐on‐a‐chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques.
Triple‐Responsive Visible‐To‐Ultraviolet‐C Upconverted Photons for Multifunctional Applications
Authors: Zi Lingzhu , Li Leipeng , Wang Chunzheng , Yang Furong , Feng Shiji , Lv Pinshu , Yang Yanmin 
Published: October 2023

AbstractOptically upconverted materials that are capable of converting long‐wavelength low‐energy photons into short‐wavelength high‐energy light have found their applications over a broad spectrum of fields, like light‐emitting diodes (LEDs), displays, bio‐detection, etc. Despite the great advances in exploring the conventional near‐infrared‐to‐visible or even near‐infrared‐to‐ ultraviolet upconverted materials, the visible‐to‐ultraviolet‐C counterparts are far from being desired. Here, a new triple‐responsive material is introduced, i.e., Pr3+‐doped Li2SrGeO4. It has the ability to absorb the visible photons at ≈450 nm from LEDs, laser diodes (LDs), and even sunlight and emit the ultraviolet‐C (UVC) light covering the 240–280 nm wavelength range. Considering the unique characteristics of the UVC photon, the promising applications of the material are further demonstrated in several scenarios, including static/dynamic labeling under the excitation of a 450 nm LED, information encryption under excitation of sunlight, and sterilization under excitation of a 450 nm LD. The work enriches the library of optically upconverted visible‐to‐UVC materials and widens the application scenarios of these materials.