bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ti3C2 MXene as Additive for Low‐Cost Textile Supercapacitors with Enhanced Electrical Performance
Authors: Yong Sheng , Yao Chengning , Hillier Nicholas , Kim Hyunho , Holicky Martin , Liu Sihui , Doherty Regan , Torrisi Felice , Beeby Stephen 
Published: December 2023

AbstractTextile‐based energy storage components are paramount for establishing invisible electronic textiles that do not require conventional rigid batteries. A novel and scalable fabrication method is reported for introducing MXene (Ti3C2Tx) into activated carbon (AC) supercapacitors to enhance electrochemical performance. Supercapacitors are prepared within a single layer of textile with a phase‐inverted polymer membrane fabricated within the textile yarn structure to form a porous, flexible, and mechanically durable separator. MXene is introduced in two different forms: 1) A multilayer MXene (m‐MXene)powder is mechanically mixed with an AC slurry and deposited onto the textile. 2) Delaminated MXene (d‐Mxene) nanosheets are spray‐coated onto the surface of spray coated AC electrode. With an organic electrolyte, 1 M tetraethylammonium tetrafluoroborate in dimethyl sulfoxide, these supercapacitors are electrochemically stable between +/− 2.6 V and demonstrate a maximum areal capacitance of 148.7 mF cm−2, an energy density of 0.921 mWh cm−2, and a power density of 1.01 mW cm−2. The addition of MXenes improves the areal capacitance and by combining both approaches an improvement of 220% is achieved compared with identical supercapacitors with standard AC electrodes. The novelty of this work is to develop a scalable and straightforward solution processing method for introducing MXene into carbon supercapacitor electrodes enabling high‐performance textile‐based energy storage devices.
Stressmechanically Reconfigurable Chiroptical Meta‐devices in Visible Band
Authors: Zhang Lu , Wang Jie , Xu Lei , Gao Feng , Zhang Wending , Mei Ting 
Published: December 2023

AbstractThe development of low‐cost and convenient procedure to produce large‐area reconfigurable chiroptical meta‐devices (CMDs) enantiomers with dynamically tunable chiroptical response in the visible band has generated significant interest, owing to its tremendous potential for applications such as optical rotary filtering, color switching, information storage, etc. Currently, many methods, such as phase change material, air pressure, bias, etc., are proposed to reconfigure the chiroptical response of the CMDs enantiomers, but still lack of ability to actively regulate the chiroptical response of the large‐area CMDs. Herein, the centimeter‐scale stressmechanically reconfigurable CMDs enantiomers with actively‐tunable chiroptical response in the visible band is proposed. The chirality sign switching and chirality intensity turning on–off of the CMDs enantiomers can be achieved by bending the flexible substrate to the desired curvature radius to turn the electromagnetic modes resonance of the CMDs enantiomers. The results provide an effective approach to supply the large‐area reconfigurable CMDs enantiomers with actively tunable chiroptical response and will open up new possibilities for chirality nanophotonic applications.
Hydrogel‐Based Delivery of antimiR‐195 Improves Cardiac Efficacy after Ischemic Injury
Authors: Eding Joep E. C. , Vigil‐Garcia Marta , Vink Marit , Demkes Charlotte J. , Versteeg Danielle , Kooijman Lieneke , Bakker Maarten H. , Schotman Maaike J. G. , Dankers Patricia Y. W. , van Rooij Eva 
Published: December 2023

AbstractMicroRNAs (miRs) are potent regulators of biology and disease. The miR‐15 family is shown to regulate cardiomyocyte proliferation and antimiR‐based inhibition induces a cardioprotective effect after myocardial infarction in mice. However, systemic delivery of antimiRs leads to accumulation in kidneys and liver, with relatively poor cardiac exposure. Injectable hydrogels are proposed to serve as sustained‐release drug delivery depots and can potentially be used to improve cardiac efficacy of antimiR therapeutics. Here, the effect of a hydrogel‐formulated antimiR‐195 after myocardial infarction in mice is studied. For this, an injectable, pH‐switchable supramolecular hydrogel based on poly(ethylene glycol) (PEG) functionalized with hydrogen bonding ureido‐pyrimidinone (UPy) units is used. Intracardiac injections under baseline conditions of this UPy–PEG hydrogelator induce a transient inflammatory response that is no longer present 7 days postinjection. In vitro experiments show that antimiR‐195 is released from the gel, and induces microRNA inhibition leading to downstream cardiomyocyte proliferation. In vivo, intramyocardial delivery of antimiR‐195 in UPy–PEG enhances cardiac target derepression compared to phosphate‐buffered‐saline‐dissolved antimiR‐195, despite a low cardiac retention. After ischemic injury, this translates into a greater therapeutic effect by increasing both target derepression and cardiomyocyte proliferation. Intramyocardial injection of UPy–PEG‐formulated antimiR‐195 is sufficient to improve cardiac efficacy of antimiR‐195.
Excessive Lipid Peroxidation in Uterine Epithelium Causes Implantation Failure and Pregnancy Loss
Authors: Lu Yafang , Shao Yuhan , Cui Weiwei , Jia Zhaoyu , Zhang Qian , Zhao Qing , Chen Zi‐Jiang , Yan Junhao , Chu Bo , Yuan Jia 
Published: December 2023

AbstractThe uterine epithelium undergoes a dramatic spatiotemporal transformation to enter a receptive state, involving a complex interaction between ovarian hormones and signals from stromal and epithelial cells. Redox homeostasis is critical for cellular physiological steady state; emerging evidence reveals that excessive lipid peroxides derail redox homeostasis, causing various diseases. However, the role of redox homeostasis in early pregnancy remains largely unknown. It is found that uterine deletion of Glutathione peroxidase 4 (GPX4), a key factor in repairing oxidative damage to lipids, confers defective implantation, leading to infertility. To further pinpoint Gpx4’s role in different cell types, uterine epithelial‐specific Gpx4 is deleted by a lactotransferrin (Ltf)‐Cre driver; the resultant females are infertile, suggesting increased lipid peroxidation levels in uterine epithelium compromises receptivity and implantation. Lipid peroxidation inhibitor administration failed to rescue implantation due to carbonylation of major receptive‐related proteins underlying high lipid reactive oxygen species. Intriguingly, superimposition of Acyl‐CoA synthetase long‐chain family member 4 (ACSL4), an enzyme that promotes biosynthesis of phospholipid hydroperoxides, along with uterine epithelial GPX4 deletion, preserves reproductive capacity. This study reveals the pernicious impact of unbalanced redox signaling on embryo implantation and suggests the obliteration of lipid peroxides as a possible therapeutic approach to prevent implantation defects.
Bond Trading: Intramolecular Metal and Ligand Exchange within a NO/Ni/Co Complex
Authors: Jana Manish , Zheng Xueyan , Le Trung , Quiroz Manuel , Guererro‐Almaraz Paulina , Darensbourg Donald J. , Darensbourg Marcetta Y. 
Published: December 2023

AbstractWith the goal of generating hetero‐redox levels on metals as well as on nitric oxide (NO), metallodithiolate (N2S2)CoIII(NO−), N2S2 = N,N‐ dibenzyl‐3,7‐diazanonane‐1,9‐dithiolate, is introduced as ligand to a well‐characterized labile [Ni0(NO)+] synthon. The reaction between [Ni0(NO+)] and [CoIII(NO−)] has led to a remarkable electronic and ligand redistribution to form a heterobimetallic dinitrosyl cobalt [(N2S2)NiII∙Co(NO)2]+ complex with formal two electron oxidation state switches concomitant with the nickel extraction or transfer as NiII into the N2S2 ligand binding site. To date, this is the first reported heterobimetallic cobalt dinitrosyl complex.
How do we prevent severe intra‐abdominal infectious complications following minimally invasive gastrectomy for cancer? The usefulness of a novel marker using computed tomography images (minimum umbilicus–vertebra diameter) and robotic surgery
Authors: Kubo Naoshi , Sakurai Katsunobu , Hasegawa Tsuyoshi , Nishimura Junya , Iseki Yasuhito , Nishii Takafumi , Shimizu Sadatoshi , Inoue Toru , Nishiguchi Yukio , Maeda Kiyoshi 
Published: December 2023

AbstractBackgroundIntra‐abdominal infectious complications (IAICs) following minimally invasive gastrectomy (MIG) for cancer sometimes worsen short‐ and long‐term outcomes. In this study, we focused on the minimum umbilicus–vertebra diameter (MUVD) in preoperative computed tomography (CT) images and robotic surgery to prevent severe IAIC occurrence.Patients and MethodsA total of 400 patients with gastric cancer who underwent 204 laparoscopic gastrectomy (LG) and 196 robotic gastrectomy (RG) procedures were enrolled in this study. We retrospectively investigated the significance of the MUVD and robotic surgery for preventing severe IAICs following MIG using multivariate and propensity score matching analysis.ResultsThe MUVD cutoff value was 84 mm by receiver operating characteristic (ROC) curve using severe IAICs as the end point. The MUVD and visceral fat area (VFA) had significantly higher area under the curve (AUC) than BMI (MUVD vs. BMI, p = 0.032; VFA vs. BMI, p < 0.01). In the multivariate analysis, high MUVD (HR, 9.46; p = 0.026) and laparoscopic surgery (HR, 3.35; p = 0.042) were independent risk factors for severe IAIC occurrence. In the propensity matching analysis between robotic and laparoscopic surgery in the high MUVD group, the RG group tended to have a lower severe IAIC rate than the LG group (0% vs. 9.8%, p = 0.056).ConclusionThe MUVD was a novel and easy‐measuring predictor of severe IAICs following MIG. Robotic surgery should be considered first in patients with gastric cancer having an MUVD value of 84 mm or higher from the perspective of severe IAIC occurrence.
Characterizing the Topological Properties of 1D Non‐Hermitian Systems without the Berry–Zak Phase
Authors: Felbacq Didier , Rousseau Emmanuel 
Published: December 2023

AbstractA new method is proposed to predict the topological properties of 1D periodic structures in wave physics, including quantum mechanics. From Bloch waves, a unique complex valued function is constructed, exhibiting poles and zeros. The sequence of poles and zeros of this function is a topological invariant that can be linked to the Berry–Zak phase. Since the characterization of the topological properties is done in the complex plane, it can easily be extended to the case of non‐Hermitian systems. The sequence of poles and zeros allows to predict topological phase transitions.
Telomere length is not a useful tool for chronological age estimation in animals
Authors: Pepke Michael L. 
Published: December 2023

AbstractTelomeres are short repetitive DNA sequences capping the ends of chromosomes. Telomere shortening occurs during cell division and may be accelerated by oxidative damage or ameliorated by telomere maintenance mechanisms. Consequently, telomere length changes with age, which was recently confirmed in a large meta‐analysis across vertebrates. However, based on the correlation between telomere length and age, it was concluded that telomere length can be used as a tool for chronological age estimation in animals. Correlation should not be confused with predictability, and the current data and studies suggest that telomeres cannot be used to reliably predict individual chronological age. There are biological reasons for why there is large individual variation in telomere dynamics, which is mainly due to high susceptibility to a wide range of environmental, but also genetic factors, rendering telomeres unfeasible as a tool for age estimation. The use of telomeres for chronological age estimation is largely a misguided effort, but its occasional reappearance in the literature raises concerns that it will mislead resources in wildlife conservation.
Sustainable asymmetric synthesis of diltiazem precursor enabled by recombinant Escherichia coli whole cells co‐expressing an engineered ketoreductase and glucose dehydrogenase
Authors: Yue Xiaoping , Li Yitong , Yang Lin , Sang Di , Huang Zedu , Chen Fener 
Published: December 2023

AbstractAs a key synthetic intermediate of the cardiovascular drug diltiazem, methyl (2R,3S)‐3‐(4‐methoxyphenyl) glycidate ((2R,3S)‐MPGM) (1) is accessible via the ring closure of chlorohydrin (3S)‐methyl 2‐chloro‐3‐hydroxy‐3‐(4‐methoxyphenyl)propanoate ((3S)‐2). We report the efficient reduction of methyl 2‐chloro‐3‐(4‐methoxyphenyl)‐3‐oxo‐propanoate (3) to (3S)‐2 using an engineered enzyme SSCRM2 possessing 4.5‐fold improved specific activity, which was obtained through the structure‐guided site‐saturation mutagenesis of the ketoreductase SSCR by reliving steric hindrance and undesired interactions. With the combined use of the co‐expression fine‐tuning strategy, a recombinant E. coli (pET28a‐RBS‐SSCRM2/pACYCDuet‐GDH), co‐expressing SSCRM2 and glucose dehydrogenase, was constructed and optimized for protein expression. After optimizing the reaction conditions, whole‐cell‐catalyzed complete reduction of industrially relevant 300 g L−1 of 3 was realized, affording (3S)‐2 with 99% ee and a space‐time yield of 519.1 g∙L−1∙d−1, representing the highest record for the biocatalytic synthesis of (3S)‐2 reported to date. The E‐factor of this biocatalytic synthesis was 24.5 (including water). Chiral alcohol (3S)‐2 generated in this atom‐economic synthesis was transformed to (2R,3S)‐MPGM in 95% yield with 99% ee.
Knockout of IRF3 and IRF7 genes by CRISPR/Cas9 technology enhances porcine virus replication in the swine testicular (ST) cell line
Authors: Sun Xiamei , Wang Jing , Mou Chunxiao , Shi Kaichuang , Bao Wenbin , Chen Zhenhai 
Published: December 2023

AbstractAntiviral vaccines for pig diseases are essential to prevent epidemic outbreaks. However, their production is often hindered by inefficient manufacturing processes that yield lower quantities of the vaccine. To accelerate the progress of various areas of bioproduction, we have considered the necessity of enhancing viral replication efficiency by optimizing ST (swine testicular) cell lines that are commonly utilized in virus manufacturing. CRISPR/Cas9 gene‐editing technology were utilized to create IRF3 or IRF7 knockout cell lines that facilitate high‐titer viral stock production. Compared to the parental cell lines, the ST IRF3/7 KO cell line displayed a compromised antiviral response to a panel of viruses (Porcine epidemic diarrhea virus, Senecavirus A, Parainfluenza virus 5, and Getah virus), as evidenced by decreased expression of interferon and certain antiviral factors. The inhibition of these responses led to heightened viral replication and increased cytopathic effects, ultimately promoting apoptosis. As a result, the development of these cell lines offers a more efficient approach for biopharmaceutical companies to boost their virus production and reduce associated costs.
Genomic insights into clostridia in bioenergy production: Comparison of metabolic capabilities and evolutionary relationships
Authors: Kumar Karan , Barbora Lepakshi , Moholkar Vijayanand S. 
Published: December 2023

AbstractBacteria from diverse genera, including Acetivibrio, Bacillus, Cellulosilyticum, Clostridium, Desulfotomaculum, Lachnoclostridium, Moorella, Ruminiclostridium, and Thermoanaerobacterium, have attracted significant attention due to their versatile metabolic capabilities encompassing acetogenic, cellulolytic, and C1‐metabolic properties, and acetone‐butanol‐ethanol fermentation. Despite their biotechnological significance, a comprehensive understanding of clostridial physiology and evolution has remained elusive. This study reports an extensive comparative genomic analysis of 48 fully sequenced bacterial genomes from these genera. Our investigation, encompassing pan‐genomic analysis, central carbon metabolism comparison, exploration of general genome features, and in‐depth scrutiny of Cluster of Orthologous Groups genes, has established a holistic whole‐genome‐based phylogenetic framework. We have classified these strains into acetogenic, butanol‐producing, cellulolytic, CO2‐fixating, chemo(litho/organo)trophic, and heterotrophic categories, often exhibiting overlaps. Key outcomes include the identification of misclassified species and the revelation of insights into metabolic features, energy conservation, substrate utilization, stress responses, and regulatory mechanisms. These findings can provide guidance for the development of efficient microbial systems for sustainable bioenergy production. Furthermore, by addressing fundamental questions regarding genetic relationships, conserved genomic features, pivotal enzymes, and essential genes, this study has also contributed to our comprehension of clostridial biology, evolution, and their shared metabolic potential.
Direct synthesis of N, S co‐doped graphynes via copolymerization strategy for electrocatalytic application
Authors: Hou Yuxin , Sun Haotian , Kong Fanan , Wang Mengyang , Li Longyu , Ren Shijie 
Published: December 2023

AbstractGraphynes (GYs) are a novel set of carbon allotropes with high potential as future catalytic electrodes for oxygen reduction reactions because of their unique physical and chemical properties. In recent years, a number of heteroatom‐doped graphdiyne (GDYs) based electrocatalysts have been developed. However, the development of GYs has made slow progress due to their limited synthetic strategies. Here, the first case of nitrogen and sulfur co‐doped graphynes (NS‐GYs) synthesized through the copolymerization between hydrogen‐deficient heterocyclic aromatic monomers via the Sonogashira–Hagihara cross‐coupling reaction is reported. The NS‐GYs exhibit abundant porosity after heat treatment with large specific area and high heteroatom content for use as potential electrocatalysts. In addition, NS‐GY‐3‐800 with the best electrocatalytic performance shows excellent power density and stability in Zn‐air batteries.
Recent developments of nanocomposite ionogels as monolithic electrolyte membranes for lithium‐based batteries
Authors: Xie Jian , Chen Qiong , Zhang Huiying , Song Rensheng , Liu Tiefeng 
Published: December 2023

AbstractTo utilize intermittent renewable energy to achieve carbon neutrality, rechargeable lithium‐based batteries have been deemed to be the most promising electrochemical systems for energy supply and storage. However, there still exist safety issues and challenges, especially originating from the intrinsic volatility and flammability of the electrolytes used in lithium‐based batteries. Due to the unique advantages of better safety, (quasi) solid‐state electrolytes have been exploited. Ionogel (IG), known as ionic liquid (IL) based monolithic quasi‐solid‐state electrolyte separator, consists of IL and gelling matrix and has become an active area of research in lithium‐based battery technology, owing to fascinating exotic characteristics including high safety (thermal stability) under extreme operating conditions, wide processing compatibility, and decent electrochemical performances. Among various gelling matrices, nanomaterials are very promising to simultaneously enhance ionic conductivity, mechanical strength, and thermal and electrochemical properties of IGs, which make the nanocomposite ionogels (NIGs). Herein, several significant advantages of NIGs as monolithic electrolyte membranes are briefly described. Also, recent advances in the NIGs for Li‐ion batteries, Li‐metal batteries, Li‐S batteries, and Li‐O2 batteries are timely and systematically overviewed. Finally, the remaining challenges and perspectives on such an interesting and active field are discussed. To the best of our knowledge, there are rare review articles focusing on the NIGs for Li‐based batteries till now. This work could offer a comprehensive understanding of recent advances and challenges of NIGs for advanced lithium storage.
Unicentric Castleman disease presenting as a longstanding axillary and chest wall mass: A case report
Authors: Zhou Wenqing , Liu Xing , Qiu Aiming , Ni Teng , Dong Tiangeng , Ding Lei 
Published: December 2023

Key clinical messageUnicentric Castleman disease, particularly the hypervascular variant subtype, commonly presents as a localized lymphadenopathy without systemic symptoms. Surgical excision is often curative for this subtype, leading to a good prognosis. However, some patients with autoimmune complications may require additional systemic therapy along with surgery. Accurate diagnosis through a combination of clinical, radiological, and pathological findings is crucial for optimal management.
Aortoduodenal fistula and abdominal aortic aneurysm as a complication of Brucella Aortitis managed with Insitu aortic aneurysm repair: A case report
Authors: Hosseinzadeh Ahmad , Zehra Jumana , Davarpanah Mohammad Ali , Farsani Mohammad Moeini , Gorji Meghdad Ghasemi , Shahriarirad Reza 
Published: December 2023

Key Clinical MessageBrucella aortitis should be one of the differential diagnoses of inflammatory aortic aneurysms. In situ repair of intermittent aortoenteric fitulae and repair of infrarenal aortic aneurysm with synthetic graft can be used in clean scarred fistulae.AbstractArterial aneurysms are very rare complications of Brucella infection. The purpose of this case report is to document a case of abdominal aortic aneurysm and primary aorto‐duodenal fistula as a complication of Brucella infection, along with the management of brucella induced aortoenteric fistula with insitu synthetic graft. We report a 53‐year‐old man with a complaint of abdominal pain and melena. Radiological evaluation revealed an inflammatory abdominal aortic aneurysm and a primary aorto‐duodenal fistula was identified during surgery. The patient underwent laparotomy, and surgical repair of the aneurysm with a bifurcated Dacron graft, while the entry of the aorto‐duodenal fistula was closed with intra‐aortic sutures. One month later, the patient tested positive for the Wright agglutination test (1:80) and Coomb's test (1:640) for brucella, and was treated with doxycycline, rifampicin, and ciprofloxacin for brucellosis. Though rare, brucella aortitis should be considered as one of the differential diagnoses of inflammatory aortic aneurysms. In situ repair of intermittent aortoenteric fistula and repair of the infrarenal aortic aneurysm with synthetic graft could be considered in a clean scarred fistula.
Modelling wax deposition of diesel in sequential transportation of product oil pipeline using optimized back propagation neural network
Authors: Yin Pengbo , Xie Lin , Zhang Hanqing , Li Weidong , Wang Wenda 
Published: December 2023

AbstractContamination of gasoline by wax deposit of diesel is a severe problem in sequential transportation of product oil pipelines in cold areas. However, most works on wax deposition are focused on crude oil. In response, this paper aims to investigate wax deposition from a unique perspective of diesel oil in sequential transportation. To this end, a cold finger apparatus was designed and constructed. It is found that the wax deposition rate of diesel oil increases with oil temperature and wax content, and decreases with cold finger temperature. A non‐monotonic variation trend is observed against shear stress. To predict diesel wax deposition rate, a back propagation (BP) neural network optimized by bald eagle search (BES) algorithm is proposed. Grey relational analysis (GRA) is employed to get the highly relevant factors as input parameters of the developed model. Prediction accuracy and generalization ability of the BES‐BP model is experimentally verified. This work will be helpful to schedule the transportation program of product oil to avoid contamination of gasoline by diesel wax deposit.