bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of degrader-targeted protein ubiquitinability
Authors: Crowe Charlotte , Nakasone Mark A. , Chandler Sarah , Tatham Michael H. , Makukhin Nikolai , Hay Ronald T. , Ciulli Alessio 
Published: February 2024

AbstractSmall molecule degraders of disease-driving proteins offer a clinically proven modality with enhanced therapeutic efficacy and the potential to tackle previously undrugged targets. Thermodynamically stable and kinetically long-lived degrader-mediated ternary complexes can drive faster, more profound and durable target degradation, however the mechanistic features by which they impact on target ubiquitination remain elusive. Here, we solve cryo-EM structures of the VHL Cullin 2 RING E3 ligase complexed with degrader MZ1, target protein Brd4BD2and primed for catalysis with its cognate E2-ubiquitin bound. We find that Brd4BD2adopts a favourable orientation towards the E2 active site. In vitro ubiquitination coupled with mass spectrometry illuminates a patch of ubiquitinable lysines on one face of Brd4BD2, with Lys456 showing optimal distance and geometry for nucleophilic attack. Our results demonstrate the proficiency of MZ1 in directing the substrate towards catalysis, explains the favourability of Brd4BD2for ubiquitination, and reveals the flexibility of the enzyme in capturing sub-optimal lysines. We propose a model for ubiquitinability of degrader-recruited targets that provides a mechanistic blueprint for further rational drug design and optimization.One-Sentence SummaryStructural assembly a PROTAC-mediated complex of whole Cullin RING E3 ligase with bound target and E2-ubiquitin reveals structural and mechanistic insights of specificity for target protein ubiquitination.
Seasonality of Respiratory, Enteric and Urinary Viruses Revealed by Wastewater Genomic Surveillance
Authors: Smith Matthew F. , Maqsood Rabia , Sullins Regan A. , Driver Erin M. , Halden Rolf U. , Lim Efrem S. 
Published: February 2024

ABSTRACTWastewater surveillance can reveal population-level infectious disease burden and emergent public health threats can be reliably assessed through wastewater surveillance. While molecular methods for wastewater monitoring of microorganisms have traditionally relied on PCR-based approaches, next-generation sequencing can provide deeper insights via genomic analyses of multiple diverse pathogens. We conducted a year-long sequencing surveillance of 1,408 composite wastewater samples collected from 12 neighborhood-level access points in the Greater Tempe area, Arizona, USA, and show that variation in wastewater viromes is driven by seasonal time and location. Wastewater virome temporal dynamics were influenced in a cyclical manner, with the most dissimilarity between samples 23 weeks apart (i.e., winter vs summer, spring vs fall). We identified diverse urinary and enteric viruses including polyomaviruses, astroviruses and noroviruses, and showed that their genotypes/subtypes shifted across season. We show that while wastewater data of certain respiratory viruses like SARS-CoV-2 strongly correlate with clinical case rates, laboratory-reported case incidences were discordant with surges of high viral load in wastewater for other viruses like human coronavirus 229E. These results demonstrate the utility of wastewater sequencing for informing decision making in public health.IMPORTANCEWastewater genomic sequencing surveillance can provide insights into the spread of pathogens in communities. Advances in next-generation sequencing methodologies allow for more precise detection of viruses in wastewater. Long-term wastewater genomic sequencing surveillance is an important tool for public health preparedness. This system can act as a public health observatory that gives real-time early warning for infectious disease outbreaks and improved response times.
School and meal characteristics associated with plate waste in K-12 cafeterias in the United States
Authors: Adjapong Eunice S. , Bender Kathryn E. , Schaefer Sophia , Roe Brian E. 
Published: February 2024

AbstractFood wasted in primary and secondary education institutions creates nutritional losses, financial inefficiencies, and environmental degradation. While there is some evidence of how particular interventions within schools may influence the amount of waste created, there is little recent information about typical levels of food waste observed in U.S. schools and how these correlate with school and meal characteristics. We analyze data reported by more than 100 schools from 24 states as part of the World Wildlife Fund’s Food Waste Warriors project and identify how plate and beverage waste from school lunches are associated with school and meal service characteristics. We find schools that permit students to choose their own amount of milk report 76% less milk waste than those reliant upon individual milk cartons while schools that implement at least one non-curricular intervention (e.g., a table where students can share unopened) report significantly less produce waste than other schools. We confirm several patterns observed or hypothesized in the literature, including more waste generated by younger students and during the earliest and shortest lunch periods. We document several novel associations including more plate waste at smaller schools, during winter months and in the Northeast region. We find several nuanced patterns of waste related to the prevalence of free and reduced meal service and whether all meal elements are offered versus served. While this study cannot support rigorous evaluation of intervention effectiveness, it provides insights into school and program characteristics that may pose challenges for schools interested in reducing student plate waste.
Household and entrepreneurial entry: an individual entrepreneurial capital perspective
Authors: Huang Yongchun , Wu Shangshuo , Chen Chengmeng , Zou Chen 
Published: February 2024

PurposeHow does the family influence individual entrepreneurial entry? The literature does not provide a satisfactory answer. In this paper, we develop an individual entrepreneurial capital perspective to systematically evaluate the impact of current households on entrepreneurship at both theoretical and empirical levels.Design/methodology/approachBased on the Global Entrepreneurship Monitor (GEM) database from 2010 to 2018, we used logit regression models to examine the relationship between household size and opportunity- and necessity-motivated entrepreneurship.FindingsThe empirical results show that with the expansion of household size, the possibility of opportunity-motivated entrepreneurship shows a trend that first declines and then rises, and the possibility of necessity-motivated entrepreneurship shows an upward trend, suggesting that there are two types of opposing mechanisms that affect the relationship between household and entrepreneurial entry.Practical implicationsFamily households are the starting point of individual growth and provide initial cognitive and social resources for decision-making. For entrepreneurs, it is necessary to make full use of household-based capital and networks to promote entrepreneurial activities. For the government, it is necessary to explore the development and implementation of household-based entrepreneurial policies.Originality/valueThrough analyses of the U-shaped relationship between household size and opportunity-motivated entrepreneurship and the positive relationship with necessity-motivated entrepreneurship, we reveal the relationship between household and entrepreneurship, reconcile the contradictions in the literature and contribute to the two fields of family studies and entrepreneurship.
Implications of metaverse, virtual reality, and extended reality for development and learning in organizations
Authors: Dastane Omkar , Rafiq Muhammad , Turner Jason J. 
Published: February 2024

Purpose
This study investigates the implications and significance of immersive technologies (viz. metaverse, virtual reality, and extended reality) in organizational learning and development.

Design/methodology/approach
Employing a strategy map (using Biblioshiny) and network analysis (using VOSViewer), the study analyzed a total of 189 Scopus-indexed documents, spanning the period 1997 to 2023.

Findings
The findings revealed four thematic clusters, knowledge management, training, e-learning, and technology. Each cluster provided insights into the various facets of development and learning in respect to these technologies. The strategy map identified key themes, revealing core ideas, emerging trends, and foundational concepts within the domain.

Practical implications
Organizations can utilize this study to incorporate metaverse, virtual reality, and extended reality in organizational development, optimizing training and boosting employee experience and productivity.

Originality/value
While most literature delves into the technical side of immersive technologies, our study uncovers their impact on development and learning in organizations, addressing a critical research gap and offering a guiding framework.
Longitudinal relationship between parental and adolescent smartphone addiction: serial mediating effects of adolescent self-esteem and depression
Authors: Mun Il Bong 
Published: February 2024

PurposeThis study longitudinally investigated the predictors and mediators of adolescent smartphone addiction by examining the impact of parental smartphone addiction at T1 on adolescent smartphone addiction at T3, as well as the separate and sequential role of adolescent self-esteem and depression at T2 as mediating factors.Design/methodology/approachThis study used a hierarchical regression and the PROCESS macro (Model 6) to investigate research model by collecting 3,904 parent-adolescent pairs. Panel data were collected from three waves of the Korean Children and Youth Panel Survey (KCYPS).FindingsFirst, the result showed that parental smartphone addiction at T1 significantly and positively predicted adolescent smartphone addiction at T3. Second, the serial mediation analysis revealed that the impact of parental smartphone addiction at T1 on adolescent smartphone addiction at T3 was mediated by adolescent self-esteem and depression at T2 independently and serially.Originality/valueThe findings enhance our comprehension of the impact of parental smartphone addiction, adolescent self-esteem and depression, on adolescent smartphone addiction.
Research attitudes among pre-service teachers: unexpected outcomes emerging from a natural experiment
Authors: Vrikki Maria , Papanastasiou Elena C. 
Published: February 2024

PurposeThe study assesses pre-service teachers' attitudes, confidence in research and intentions to use research by comparing the effectiveness of practical versus theoretical training in research methods courses.Design/methodology/approachThis natural experiment examines the impact of the adaptations made to a research methods course for 848 pre-service teachers, due to the COVID-19 pandemic. The participants were naturally divided into two cohorts, each attending either the applied version, which required the completion of a whole research study, or the theoretical version, which did not require data collection and analyses. The data were collected through three questionnaires measuring attitudes, confidence and intentions toward research.FindingsInferential statistics revealed that pre-service teachers in the theoretical course (1) had more positive attitudes toward research and less anxiety, (2) had more intentions to integrate research in their daily practice and (3) had more confidence in engaging in educational research, compared to the pre-service teachers who completed the applied version of the course.Originality/valueThis study uniquely capitalizes on course adaptations, imposed due to the pandemic, to compare attitudes toward research. This is an ideal comparison because comparing attitudes of participants from different contexts involves many confounding variables. The study’s significance is amplified as, it not only elucidates the variances in attitudes, but also underscores the intricate relationship these attitudes share with the design of research courses. The insights yielded by this study offer substantial potential for reshaping pedagogical strategies in research methods instruction, thereby serving as a cornerstone for future educational innovations.
Recent developments in EU anti-corruption strategy: the missing element of the return of corrupt assets to “victim countries”
Authors: Ochnio Ariadna H. 
Published: February 2024

Purpose
Recent developments in the EU’s anti-corruption strategy have brought the EU closer to meeting the UNCAC’s objectives, i.e. the Proposal for a Directive on combating corruption (2023) and the Proposal for a Directive on Asset Recovery and Confiscation (2022). This paper aims to discuss these developments from the perspective of the UNCAC, to identify missing elements in the EU’s asset recovery mechanisms.

Design/methodology/approach
Critical approach towards EU anti-corruption policy (discussing the problems and solutions). Review of EU developments in asset recovery law.

Findings
There is a political will on the part of the EU to fight corruption through the rules enshrined in the UNCAC. However, improving EU law by introducing a new type of confiscation of unexplained wealth and criminalising illicit enrichment, without establishing convergent rules for the return of corrupt assets from EU territory to the countries of origin, cannot be seen as sufficient action to achieve the UNCAC’s objectives. In modelling mechanisms of the return of assets, the EU should search for solutions to overcome the difficulties resulting from the ordre public clause remaining a significant factor conditioning mutual legal assistance.

Originality/value
This paper discusses the possible input of the EU, as a non-State Party to the UNCAC, to advance implementing the UNCAC solutions on asset recovery by establishing convergent rules for the return of corrupt assets from EU territory to countries of origin.
Phygital approach to value co-creation in international museums
Authors: Clemente Laura , Iodice Gesualda , Carignani Francesco , Greco Fabio , Bifulco Francesco 
Published: February 2024

Purpose
The purpose of this paper is, through an exploratory analysis, to identify good practices implemented by international museums in the phygital context and their classification in terms of customer experiences, in order to identify innovative cultural value creation and co-creation practices.

Design/methodology/approach
The authors adopt a qualitative approach of multiple case studies. The analysis conducted formed the information base through which to proceed with the classification of phygital customer experiences through the extended reality technologies framework

Findings
The analysis conducted on the selected international museums shows that the phygital formula can take on different characteristics depending on the technologies used and the purpose to be achieved and can be a useful tool for the co-creation of cultural value.

Originality/value
The originality of this contribution lies in the comparative analysis proposed among the case studies to intercept best practices in the phygital field, in the classification of phygital experiences through a novel frame of reference and in the identification of prospects for improvement of an emerging phenomenon in the literature on cultural sector management.
Developing non-traditional firm-specific advantages in domestic strategic factor markets: evidence from China
Authors: Wan Feng , Williamson Peter , Pandit Naresh 
Published: February 2024

Purpose
Chinese firms are winning market share from foreign multinational enterprises in domestic markets. The international business literature suggests that this is happening because these firms are developing non-traditional firm-specific advantages (FSAs). Strategic factor market (SFM) theory provides a good basis for explaining how this is happening. However, it is underdeveloped in terms of analysing unique resources and unique access to those resources by Chinese firms in their domestic markets. This paper aims to develop a framework to understand how Chinese firms have developed non-traditional FSAs.

Design/methodology/approach
The case study method is adopted to explore how Chinese firms develop non-traditional FSAs. Specifically, the authors compare paired case studies of a Chinese firm and a foreign multinational in each of two industries.

Findings
The authors find that Chinese firms have developed non-traditional FSAs because of more relevant experience, better adapted strategies and privileged relationships. This has enabled Chinese firms to develop non-traditional FSAs.

Originality/value
The authors propose a framework that conceptualises non-traditional FSA development in Chinese firms as a product of superior access to unique and valuable resources in their domestic SFMs.
Can common institutional ownership inhibit corporate over-financialization? Evidence from China
Authors: Ding Hao 
Published: February 2024

PurposeCommon institutional ownership is a phenomenon that has extended throughout the capital markets in recent years and has a significant impact on business strategy decisions. The study intends to investigate the effect of common institutional ownership on corporate over-financialization and potential functioning mechanisms.Design/methodology/approachUsing panel data from Chinese-listed companies over the period of 2003–2021, the authors conduct regression models which controlled year-, industry- and regional fixed effects to explore the impact of common institutional ownership on corporate over-financialization.FindingsThis study concludes that corporate over-financialization may be prevented via common institutional ownership. The mechanism test suggests that common institutional ownership inhibits corporate over-financialization by improving internal control quality and enhancing financial flexibility. Besides, heterogeneity analysis shows that the inhibiting effect of common institutional ownership on corporate over-financialization is more pronounced in stability-oriented institutional investors and high financing constraints firms.Originality/valueThis paper makes a valuable contribution to the current studies on effective strategies to prevent enterprises from becoming overly financialized by recognizing common institutional ownership. Furthermore, this paper adds to the research on common institutional ownership’s economic consequences. Finally, this study provides management implications for how to optimize corporate governance structures, curb the financialization of entities in practice and promote the development of the real economy.
Nonsimilar mixed convection analysis of ternary hybrid nanofluid flow near stagnation point over vertical Riga plate
Authors: Farooq Umer , Bibi Amara , Nawaz Abbasi Javeria , Jan Ahmed , Hussain Muzamil 
Published: February 2024

PurposeThis work aims to concentrate on the mixed convection of the stagnation point flow of ternary hybrid nanofluids towards vertical Riga plate. Aluminum trioxide (Al2O3), silicon dioxide (SiO2) and titanium dioxide (TiO2) are regarded as nanoparticles, with water serving as the base fluid. The mathematical model incorporates momentum boundary layer and energy equations. The Grinberg term for the viscous dissipation and the wall parallel Lorentz force coming from the Riga plate are taken into consideration in the context of the energy equation.Design/methodology/approachThrough the use of appropriate nonsimilar transformations, the governing system is transformed into nonlinear nondimensional partial differential equations (PDEs). The numerical method bvp4c (built-in package for MATLAB) is used in this study to simulate governing equations using the local non-similarity (LNS) approach up to the second truncation level.FindingsNumerous graphs and numerical tables expound on the physical properties of the nanofluid temperature and velocity profiles. The local Nusselt correlations and the drag coefficient for pertinent parameters have been computed in tabular form. Additionally, the temperature profile drops while the velocity profile increases when the mixed convection parameter is included to oppose the flow.Originality/valueThe fundamental goal of this work is to comprehend how ternary nanofluids move towards a vertical Riga plate in a mixed convective domain with stagnation point flow.
The “here and now” effect: JoMO, FoMO and the well-being of social media users
Authors: Eitan Tal , Gazit Tali 
Published: February 2024

PurposeThe rapid growth of social media has changed how people interact and connect with one another while also giving rise to new social-media associated psychological experiences, such as the well-known fear of missing out (FoMO) and the somewhat new phenomena, the joy of missing out (JoMO). This study aims to develop a new scale for measuring JoMO and explore its independent nature and relationships with well-being, social comparison and demographic variables.Design/methodology/approachA sample of 230 participants filled out an online survey, including questions about demographic details, well-being, social media engagement, social comparison, FoMO and a new JoMO scale. The data was analyzed using exploratory factor analysis, hierarchical regression and structural equation modeling.FindingsThe study confirmed the validity and reliability of the new JoMO scale in three sub-categories: active JoMO, passive JoMO and coping with disconnection. Younger individuals and those who were single, with weaker psychological well-being, higher engagement in social media and greater social comparison inclinations tended to experience higher levels of FoMO. Conversely, older individuals, women and those who enjoyed stronger psychological well-being and reduced social media engagement demonstrated higher levels of JoMO. The findings also suggest a complex relationship between FoMO and JoMO.Practical implicationsThe creation of an innovative JoMO measurement tool could transform both scholarly research and practical approaches to digital media interactions. This tool offers a deeper understanding of the intricate links between JoMO and factors such as social comparison and FoMO, paving the way for targeted interventions. By utilizing this, experts can foster healthier online behaviors and better psychological health through increased JoMO consciousness, reduced social media engagement and social comparisons, and FoMO management. Therefore, this fresh instrument assists in clarifying and improving how individuals engage with digital technology.Originality/valueThis research validates the JoMO scale, enhancing our understanding of JoMO and its potential effects on well-being, as well as its associations with other variables. In addition, this research provides valuable insights for future studies on social media use and JoMO, and for developing effective strategies for managing healthier online experiences.