bluuebunny/crossref_metadata_2025_split huggingface dataset:
Belajar Menyimak dan Menulis Berdasarkan Cerita Rakyat Pulau Madura (Kesenian Topeng Dalang) Bagi Pebelajar BIPA Tingkat Dasar
Authors: Fatmawati Ira , Hani’ah Hani’ah 
Published: December 2023

Keterampilan menyimak dapat dipengaruhi dari (1) tingkat frekuensi, (2) gender, (3) motivasi. Daya simakan dapat ditingkatkan dengan tingkat frekuensi dan motivasi, bahkan dddipengaruhi juga dengan gender. Menyimak merupakan dasar dari keterampilan berbahasa. Seseorang yang tidak dapat mendengar maka secara otomatis dia tidak dapat berbicara, menulis, dan membaca. Kegiatan pembelajaran menyimak dan menulis dapat dilakukan secara bersamaan dengan tahapan pembelajaran sebagai berikut, (1) bagian 1 belajar menyimak gambar, (2) bagian 2 belajar menyimak, (3) bagian 3 menceritakan kembali cerita tari topeng yang telah disimak. Kegiatan menyimak dapat dilakukan dengan cara (1) menyimak gambar, (2) simak ulang ucap, (3) simak kerjakan.
Pemanfaatan Serasah Daun Bambu Menjadi Pupuk Organik di Desa Alu Kabupaten Polewali Mandar
Authors: Karim Faradilah Farid , Indhasari Fitri , Idris Andi Irmayanti , Arhim Muhammad 
Published: December 2023

Alu Village is one of the villages in Polewali Mandar Regency, West Sulawesi Province. Alu Village has a bamboo forest covering an area of 18 ha. The existence of bamboo plants in Alu Village is very abundant, so bamboo leaf litter has the potential to be used as organic fertilizer. Most of the people of Alu Village make their living as farmers. Utilizing bamboo leaf litter into compost is a good alternative for the community. However, the lack of public knowledge regarding making compost means that many are still reluctant to use this fertilizer. This community service program aims to educate the public regarding the use of bamboo litter as compost and minimize bamboo litter waste in Alu Village. The method used is direct provision of materials and practice of making organic fertilizer from bamboo litter through the participation of active participants. The use of bamboo leaf litter as fertilizer, apart from utilizing waste, is also expected to have an influence on plant growth on agricultural land and plantations in local communities.
Laboratory Experiments Qualify Bit Influence on High-Frequency Torsional Oscillations
Authors: Carpenter Chris 
Published: December 2023

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 212566, “Qualifying Bit Influence on High-Frequency Torsional Oscillations Based on Full-Scale Laboratory Experiments,” by Armin Kueck, Eliah Everhard, and Xu Huang, Baker Hughes, et al. The paper has not been peer reviewed.

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High-frequency torsional oscillations (HFTOs) generate dynamic loads that can damage drilling tools, resulting in cracks, twistoffs, or broken electronics. Recently, a full-scale drilling test rig was proven to generate verified HFTO behavior under laboratory conditions. This rig allows for a comprehensive study of the influences of bit characteristics on HFTO. The complete paper presents methods to qualify bit features to suppress HFTO.

Laboratory Rig Setup
Test-Rig Design. The full-scale laboratory test rig drills rocks in a pressurized rock chamber. Rate of penetration (ROP), weight on bit (WOB), rotational speed, pressure, bit type, and rock type can be varied. The simulator consists of an open-loop mud-circulation system with capacity for 200 bbl of fluid, two 1,000-hp triplex pumps capable of up to 500 gal/min, a hoisting mechanism for raising and loading the drillstring up to 10,000 lbf, a 1,000-hp rotary drive capable of up to 10,000 ft-lbf, and a pressure vessel rated to 10,000 psi.
High-frequency measurement instrumentation, including in-bit vibration sensors, records the tangential accelerations and dynamic torque at various positions in the BHA. The mounted device can be seen in the top left photo in Fig. 1.
Measurement. To initially characterize the frequency response of the system, an impact test was performed on the system in a suspended nonoperating state with roving accelerometers (sensors) positioned as indicated by the blue lines in Fig. 1. Also indicated are the free-end and fixed-end boundary conditions at the bit (left) and drive (right), respectively, as well as the point of reference impact. The data from each pair of sensors are then processed to separate the torsional motions from lateral.
Because HFTO is a self-excited vibration, it must be validated that this type of vibration is actually excited in the laboratory setup. To demonstrate that the excitation mechanism is representative for the field, one of the test results was used as a reference. A laboratory investigation showed that the measured vibration matches characteristics of self-excited vibrations. Investigations in the laboratory will, therefore, lead to valid solutions in the field.
The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cancer cells’ survival in NRAS/MAPK-driven melanoma
Authors: Feichtenschlager Valentin , Chen Linan , Zheng Yixuan James , Ho Wilson , Sanlorenzo Martina , Vujic Igor , Fewings Eleanor , Lee Albert , Chen Christopher , Callanan Ciara , Lin Kevin , Qu Tiange , Hohlova Dasha , Vujic Marin , Hwang Yeonjoo , Lai Kevin , Chen Stephanie , Nguyen Thuan , Muñoz Denise P , Kohwi Yoshinori , Posch Christian , Daud Adil , Rappersberger Klemens , Kohwi-Shigematsu Terumi , Coppé Jean-Philippe , Ortiz-Urda Susana 
Published: December 2023

Abstract
Finding effective therapeutic targets to treat NRAS-mutated melanoma remains a challenge. Long non-coding RNAs (lncRNAs) recently emerged as essential regulators of tumorigenesis. Using a discovery approach combining experimental models and unbiased computational analysis complemented by validation in patient biospecimens, we identified a nuclear-enriched lncRNA (AC004540.4) that is upregulated in NRAS/MAPK-dependent melanoma, and that we named T-RECS. Considering potential innovative treatment strategies, we designed antisense oligonucleotides (ASOs) to target T-RECS. T-RECS ASOs reduced the growth of melanoma cells and induced apoptotic cell death, while having minimal impacton normal primary melanocytes. Mechanistically, treatment with T-RECS ASOs downregulated the activity of pro-survival kinases and reduced the protein stability of hnRNPA2/B1, a pro-oncogenic regulator of MAPK signaling. Using patient- and cell line- derived tumor xenograft mouse models, we demonstrated that systemic treatment with T-RECS ASOs significantly suppressed the growth of melanoma tumors, with no noticeable toxicity. ASO-mediated T-RECS inhibition represents a promising RNA-targeting approach to improve the outcome of MAPK pathway-activated melanoma.
How family precepts delivered enduring prosperity to merchants in early-modern Japan: A microeconomic perspective
Authors: Sasaki Katsuro , Ono-Yoshida Rie 
Published: December 2023

Abstract
Wealthy merchants in the Edo period often subscribed to the ideology emphasizing "family survival" as their management goal and, accordingly, set down family precepts summarizing business principles to pass on to their descendants. Existing studies on the management of long-lived companies, including the family precepts, have attempted to identify their reasons for longevity and apply the learning to modern corporate governance. However, there is little research on why and how the ideology originated due to the lack of historical evidence from those days. We use economic-model analysis to examine under what socioeconomic and other conditions the ideology and family precepts emerged and took root to address the issue. This study applies the finite-term overlapping generation model in economics and discusses how a merchant in each generation managed their inheritance to maximize their utility. The model assumes that wealthy merchants' utility depends on their consumption and progeny's utility. We introduce a new parameter representing the degree of empathy the predecessor has toward their successor. Our result suggests that this new parameter and merchants' expected duration of their business were vital in determining the extent of a merchant family's prosperity. In conclusion, if wealthy merchants establish family precepts emphasizing "family survival" and a commitment to simplicity and frugality, and steadily pass them on to their descendants, the family will last long and prosper. Our results reinforce prior findings that family precepts had a significant role in the family's survival and the development of its human resources.

JEL Classification N85・D90
Severe obesity may be an oligogenic condition: evidence from 1,714 adults seeking treatment in the UK National Health Service.
Authors: Almansoori Sumaya , Amin Hasnat A , Alsters Suzanne I. , Handley Dale , Yiorkas Andrianos , Hashim Nikman , Ramzi Nurul , Bonanomi Gianluca , Small Peter , Purkayastha Sanjay , Haelst Mieke , Walters Robin , Roux Carel Le , Chahal Harvinder , Drenos Fotios , Blakemore Alexandra 
Published: December 2023

Abstract
Severe (class III) obesity is a chronic, relapsing condition, with a high burden of co-morbidity and mortality. Previous evidence has established genetics as an important contributing factor. We therefore designed a custom genotyping array to screen a cohort of UK patients seeking treatment for severe obesity. 1,714 participants were genotyped using a custom AXIOM array, focusing on rare (minor allele frequency < 0.01) variants, with CADD-PHRED ≥ 15 in 78 genes known/suspected to cause Mendelian forms of obesity. Concordance analyses of 22 duplicate samples and 66 samples with whole exome sequence data revealed good genotyping reliability. We identified the proportion of study participants who carried, or were homozygous for, rare, predicted-deleterious variants in genes with dominant and recessive modes of inheritance (MOI), respectively. 27% of patients carried relevant mutations consistent with the expected MOI, which was very similar to the rate observed in the UKB 50K whole exome sequencing dataset. However, the clinical obesity cohort were more likely to carry two or more such variants, in separate genes, than UK Biobank participants (p = 0.018). In conclusion, our results provide evidence: that (i) custom genotyping arrays, used with improved algorithms can allow reliable, cost-effective screening for rare genetic variants; (ii) rare mutations in “obesity genes” may be at high prevalence among bariatric patients, as well as in the general population; and (iii) that severe obesity may have an oligogenic pattern of inheritance in some cases.
Improving intervention development and implementation using the Person-Based Approach (PBA) to co-participatory stakeholder engagement: a worked example of a behavioural intervention to improve asthma reviews in primary care
Authors: Santillo Marta , Morton Kate , Velthoven Michelle Helena Van , Yardley Lucy , Thomas Mike , Wang Kay , Ainsworth Ben , Tonkin-Crine Sarah 
Published: December 2023

Abstract

Backgrounds: New interventions need to fit with existing ways of working in primary care. The Person-Based Approach (PBA) is a way to tailor interventions to context and stakeholder engagement can be a more or lesser part of this approach. Using co-participatory stakeholder engagement, as part of the PBA, provides a novel way to involve clinicians and PPI representatives in intervention development to maximise the acceptability and fine tune implementation of the intervention.
Methods: A behavioural intervention was developed using the PBA, emphasizing co-participatory stakeholder engagement of clinicians and PPI contributors. We developed an online intervention to support the use of a Fractional Exhaled Nitric Oxide (FeNO) test to guide clinical decisions during routine asthma reviews in primary care. Decisions about intervention planning and development were made through regular meetings and interactions with patients with asthma and primary care clinicians using the intervention.
Results: A varied group of stakeholders were involved, including GPs, practice nurses, clinical pharmacists, patients with asthma and academics in primary care and respiratory research. Including active stakeholder engagement throughout the intervention development process enabled better understanding of the context in which primary care asthma reviews happen, the specific needs of patients with asthma and clinicians conducting reviews and how to best meet these needs to increase the acceptability of the intervention and fit with practice. Stakeholder feedback also identified necessary changes to intervention materials, which would not have been identified by the research team alone.
Discussion: This working example provides insights on how stakeholder engagement complemented and strengthened research activities and provides a model for understanding how best to utilise the feedback received by stakeholders to maximise adoption of interventions and their implementation in practice.
Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes
Authors: Yu Chunshui , Ji Yuan , Liu Nana , Yang Yunjun , Wang Meiyun , Chen Jingliang , Zhu Wenzhen , Qiu Shijun , Geng Zuojun , Cui Guangbin , Yu Yongqiang , Liao Weihua , Zhang Hui , Gao Bo , Xu Xiaojun , Han Tong , Yao Zhengwei , Zhang Quan , Qin Wen , Liu Feng , Liang Meng , Wang Sijia , Xu Qiang , Xu Jiayuan , Fu Jilian , Zhang Peng , Li Wei , Shi Dapeng , Wang Caihong , Lui Su , Yan Zhihan , Chen Feng , Zhang Jing , Shen Wen , Miao Yanwei , Wang Dawei , Gao Jia-Hong , Zhang Xiaochu , Xu Kai , Zuo Xi-Nian , Zhang Long Jiang , Ye Zhaoxiang , Li Mulin Jun , Xian Junfang , Zhang Bing , Consortia CHIMGEN 
Published: December 2023

Abstract
The amygdala is a small but critical multi-nucleus structure for emotion, cognition, and neuropsychiatric disorders. Although genetic associations with amygdala and subnucleus volumes have been investigated in sex-mixed European populations, cross-ancestry and sex-stratified analyses are still lacking. Here we conducted cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in 6,923 Chinese and 48,634 European individuals. We identified 191 variant-trait associations (P < 2.38 × 10−9), including 47 new associations (12 new loci) in sex-mixed univariate analyses and seven additional new loci in sex-mixed and sex-stratified multivariate analyses. We identified 12 ancestry-specific and two sex-specific associations. The identified genetic variants include 16 fine-mapped causal variants and regulate amygdala and fetal brain gene expression. They are enriched for brain development and affect mood, cognition, and neuropsychiatric disorders. These results indicate that cross-ancestry and sex-stratified genetic association analyses may provide insight into the genetic architectures of amygdala and subnucleus volumes.
Identification a novel autophagy-related long non-coding RNA prognostic signature for pancreatic adenocarcinoma
Authors: Chen LuYao , Zhang YuFeng , Yin ShengAo , Liang ShuHan , Liu YaXing , Wu Dongkai , Shi XingSong , Qu GeXi , He Yuan 
Published: December 2023

Abstract
Pancreatic adenocarcinoma (PAAD) is one of the most common malignant tumors in the digestive system. At present, the prognosis and 5-year survival time are still unsatisfied. Autophagic genes have been demonstrated as a crucial factor in pancreatic cancer progression, we studied the potential prognostic value of autophagy associated long non-coding RNA (lncRNA) in patients with pancreatic cancer. In our research, we summarized five autophagy-related lncRNAs based on The Cancer Genome Atlas (TCGA) pancreatic cancer patient’s data. According to the prognostic lncRNAs, we established a prognostic risk signature and then divided all the patients into low-risk or high-risk groups based on their risk scores. The overall survival (OS) time in the high-risk group is shorter than low risk group (HR = 3.75, 95%CI: 2.45–5.73, p < 0.001). The autophagy-related lncRNA signature was an independent prognostic predictor with an AUC value of 0.694 (1 year) and 0.703 (5 year). Nomogram was constructed to predict the patients’ survival probabilities based on the risk scores. Gene set enrichment analysis was performed to detect the signaling pathway involved in the different groups, which revealed the related genes were markedly enriched in multiple signaling pathways in high or low- risk group. Moreover, we examined these lncRNAs expression in HPNE cells and three pancreatic cancer cell lines including Mia-PaCa-2, CFPAC-1 and Panc-1. In addition, the biological function between the high and low risk groups was significantly different. We also analyzed the relationship between the autophagy-related lncRNAs signature and pancreatic cancer infiltration lymphocytes via CIBERSORT method in this study. To summarize, the 5-autophagy related lncRNAs we screened in this study has prognostic capability for PAAD and may play a crucial role in pancreatic cancer biology progress.
On a Simulation-based Chatter Prediction System by Integrating Relative Entropy and Dynamic Cutting Force
Authors: vi trung kien , Luo Bo-Cheng , Wu Hsiang-Chiu , Wu Meng-Jie , Kao Yung Chou 
Published: December 2023

Abstract
This paper aims to develop a simulation-based chatter prediction system using relative entropy - Kullback-Leibler Divergence (KLD), and the NC program can be modified to become non-chatter. Chatter is one of the major concerns when machining mechanical components on a CNC machine. In general, the majority of the previous research methods achieved non-chatter stable machining by assigning the appropriate machining parameters: (1) spindle speed, (2) feed rate, and (3) depth of cut based on the generated SLD (Stability Lobe Diagram). Non-chatter stable machining can also be accomplished by manually adjusting the spindle override percentage on the operation panel or the values in the CNC controller via networking once chatter is detected during the machining processes. The creation of SLD must consider two essential parameters: cutting force coefficient (CFC) and frequency response function (FRF). The CFC can be obtained from cutting experiment data related to a paired tool and workpiece, and the FRF can be calculated from the tapping test experiment. Then, the CFC and FRF are stored in the database of the developed system. The simulation-based chatter prediction calculates the KLD value based on the relativity of the dynamic cutting force and the static cutting forces so as to predict whether there is chatter in the NC program or not. The NC program can be adjusted to become non-chatter if there is chatter predicted. The proposed method has been successfully verified through on-site machining, showing very promising achievement.
Enhanced Channel Estimation for RIS-assisted OTFS Systems by Introducing ELM Network
Authors: Qing Chaojin , Liu Zhiying , Wang Li , Ling Guowei , Hu Wenquan , Cai Xi , Lin Hui 
Published: December 2023

Abstract
In high-mobility communication scenarios, leveraging reconfigurable intelligent surfaces (RIS) to assist orthogonal time frequency space (OTFS) systems proves advantageous. However, the integration of RIS into OTFS systems has added complexity to the channel estimation (CE). Utilizing the benefits of machine learning (ML) to address such intricate issues holds the potential to reduce the complexity of CE. Yet, there is a lack of investigations of ML-based CE in RIS-assisted OTFS systems, leaving significant blanks and posing challenges for intelligent applications. Additionally, ML-based CE still faces numerous difficulties, such as intricate parameter tuning and long training time. Inspired by the inherent advantages of the single-hidden layer feed-forward network structure, we introduce extreme learning machine (ELM) into RIS-assisted OTFS systems to improve their CE accuracy. In this method, we integrate a threshold-based approach to extract initial feature, aiming to remedy the inherent limitations of ELM network, such as inadequate network parameters compared to the deep learning network. This initial feature is then leveraged to enhance ELM learning ability, leading to improved CE accuracy. By using the classic message passing algorithm to detect data symbols, simulation results demonstrate that the proposed method efficiently improves the symbol detection (SD) performance of RIS-assisted OTFS systems. Furthermore, the SD performance is robust against the impacts of the parameter variations.
Effect of concentration and functional group of cellulose nanocrystals on the rheological and filtration properties of water- based drilling fluids at various temperatures
Authors: Peng Jianghao , Zhang Hehai , Li Xinliang , Fang Shenwen , Duan Ming , Wan Liqiong 
Published: December 2023

Abstract

Cellulose nanocrystals (CNCs) have great application potential as environmentally friendly and multifunctional additives in drilling fluids. But their practical performance and utilization principles still need to further clarify. This paper investigated the effectiveness of two kinds of typical CNCs, including carboxylated cellulose nanocrystals (C-CNC) and sulfonated cellulose nanocrystals (S-CNC), on the rheological and filtration properties of water-based drilling fluids (WBDFs) under different concentrations. The results indicated that at room temperature, 150℃, and 180℃, both of C-CNC and S-CNC could be used as rheology modifiers for bentonite WBDFs, and 1.0% of C-CNC performed the best outstanding viscosity-increasing effect and shear-thinning behavior. The fitting results of rheological models showed that all of the samples are closest to the Hersche-Bulkley model. Under room temperature and 150℃, C-CNC and S-CNC with higher concentrations (1.0%) had a better fluid loss reduction effect. However, at 180℃, C-CNC and S-CNC with lower concentration (0.5%) showed superior filtration property, while 1.0% of C-CNC and S-CNC unexpectedly increased the fluid loss. In the whole, C-CNC performed better properties in rheological modification and fluid loss reduction than S-CNC. Microstructure analysis demonstrated the dispersion stability of C-CNC was better, and these nanoparticles easily adsorbed onto bentonite and exhibited strong gel formation capacity. The addition of CNCs with high concentrations was beneficial for decreasing the zeta potential of WBDFs and improving their colloidal stability at 150℃, while it would produce adverse influence when the temperature was raised to 180℃. It was referred that the stiff network among bentonite, CNCs, and immobilized water molecules was destroyed to varying degrees after aging at high temperatures. Especially when a higher concentration of CNC existed, CNCs particles were greatly easier to attract each other, agglomerate, and form many permeation channel, thereby resulting in decrease of the viscosity and increase of the fluid loss. Therefore, it was suggested that the use of CNCs should be determined according to their characteristics, formation temperature, and other actual operation conditions.