bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chiral arylsulfinylamides as reagents for visible light-mediated asymmetric alkene aminoarylations
Authors: Hervieu Cédric , Kirillova Mariia S. , Hu Yawen , Cuesta-Galisteo Sergio , Merino Estíbaliz , Nevado Cristina 
Published: January 2024

AbstractTwo- or one-electron-mediated difunctionalizations of internal alkenes represent straightforward approaches to assemble molecular complexity by the simultaneous formation of two contiguous Csp3 stereocentres. Although racemic versions have been extensively explored, asymmetric variants, especially those involving open-shell C-centred radical species, are much more limited both in number and scope. Here we describe enantioenriched arylsulfinylamides as all-in-one reagents for the efficient asymmetric, intermolecular aminoarylation of alkenes. Under mild photoredox conditions, nitrogen addition of the arylsulfinylamide onto the double bond, followed by 1,4-translocation of the aromatic ring, produce, in a single operation, the corresponding aminoarylation adducts in enantiomerically enriched form. The sulfinyl group acts here as a traceless chiral auxiliary, as it is eliminated in situ under the mild reaction conditions. Optically pure β,β-diarylethylamines, aryl-α,β-ethylenediamines and α-aryl-β-aminoalcohols, prominent motifs in pharmaceuticals, bioactive natural products and ligands for transition metals, are thereby accessible with excellent levels of regio-, relative and absolute stereocontrol.
Programmable Heisenberg interactions between Floquet qubits
Authors: Nguyen Long B. , Kim Yosep , Hashim Akel , Goss Noah , Marinelli Brian , Bhandari Bibek , Das Debmalya , Naik Ravi K. , Kreikebaum John Mark , Jordan Andrew N. , Santiago David I. , Siddiqi Irfan 
Published: January 2024

AbstractThe trade-off between robustness and tunability is a central challenge in the pursuit of quantum simulation and fault-tolerant quantum computation. In particular, quantum architectures are often designed to achieve high coherence at the expense of tunability. Many current qubit designs have fixed energy levels and consequently limited types of controllable interactions. Here by adiabatically transforming fixed-frequency superconducting circuits into modifiable Floquet qubits, we demonstrate an XXZ Heisenberg interaction with fully adjustable anisotropy. This interaction model can act as the primitive for an expressive set of quantum operations, but is also the basis for quantum simulations of spin systems. To illustrate the robustness and versatility of our Floquet protocol, we tailor the Heisenberg Hamiltonian and implement two-qubit iSWAP, CZ and SWAP gates with good estimated fidelities. In addition, we implement a Heisenberg interaction between higher energy levels and employ it to construct a three-qubit CCZ gate, also with a competitive fidelity. Our protocol applies to multiple fixed-frequency high-coherence platforms, providing a collection of interactions for high-performance quantum information processing. It also establishes the potential of the Floquet framework as a tool for exploring quantum electrodynamics and optimal control.
Hourly values of an advanced human-biometeorological index for diverse populations from 1991 to 2020 in Greece
Authors: Giannaros Christos , Agathangelidis Ilias , Galanaki Elissavet , Cartalis Constantinos , Kotroni Vassiliki , Lagouvardos Konstantinos , Giannaros Theodore M. , Matzarakis Andreas 
Published: January 2024

AbstractExisting assessments of the thermal-related impact of the environment on humans are often limited by the use of data that are not representative of the population exposure and/or not consider a human centred approach. Here, we combine high resolution regional retrospective analysis (reanalysis), population data and human energy balance modelling, in order to produce a human thermal bioclimate dataset capable of addressing the above limitations. The dataset consists of hourly, population-weighted values of an advanced human-biometeorological index, namely the modified physiologically equivalent temperature (mPET), at fine-scale administrative level and for 10 different population groups. It also includes the main environmental drivers of mPET at the same spatiotemporal resolution, covering the period from 1991 to 2020. The study area is Greece, but the provided code allows for the ease replication of the dataset in countries included in the domains of the climate reanalysis and population data, which focus over Europe. Thus, the presented data and code can be exploited for human-biometeorological and environmental epidemiological studies in the European continent.
Micro computed tomography images of capillary actions in rough and irregular granular materials
Authors: Nadimi Sadegh , Mendes Joao , López Alejandro , Schröer Laurenz , Manoorkar Sojwal , Ellman Sharon , Cnudde Veerle , Bruno Agostino Walter 
Published: January 2024

AbstractThe present work investigates the effect of both surface roughness and particle morphology on the retention behaviour of granular materials via X-ray micro-computed tomography (µCT) observations. X-ray µCT images were taken on two types of spherical glass beads (i.e. smooth and rough) and two different sands (i.e. natural and roughened). Each sample was subjected to drainage and soaking paths consisting in a multiphase ‘static’ flow of potassium iodine (KI) brine (wetting phase) and dry air (non-wetting phase). Tomograms were obtained at different saturation states ranging from fully brine saturated to air dry conditions with 6.2 μm voxel size resolution. The data acquisition and pre-processing are here described while all data, a total of 48 tomograms, are made publicly available. The combined dataset offers new opportunities to study the influence of surface roughness and particle morphology on capillary actions as well as supporting validation of pore-scale models of multiphase flow in granular materials.
Intimate partner violence during pregnancy and risks of low birth weight and preterm birth in hospitals of Tigray, Northern Ethiopia
Authors: Gebreslasie Kahsay Zenebe , Weldemariam Solomon , Gebre Gelawdyos , Zenebe Dawit , Mehari Mihreteab , Birhane Aklil , Dewey Rebecca Susan 
Published: January 2024

AbstractIntimate partner Violence (IPV) can affect any woman, irrespective of their economic status, religion, or culture. This is a human-rights issue and due to its prevalence and adverse effects on pregnancy and birth, it must be given greater attention. Further, there is a lack of data in the Tigray region about adverse birth outcomes due to intimate partner violence during pregnancy. The aim of this study was to assess intimate partner violence during pregnancy and its association with low birth weight and preterm birth in Tigray region. Across-sectional study design was used. 647 women were involved in the study. Simple random sampling techniques were employed to select health facilities and systematic sampling was used to select study participants. Data were entered using Epi info version 3.5.1 and was analyzed using SPSSversion 20. Logistic regression analysis was conducted to assess the association between exposure to intimate partner violence during pregnancy and preterm birth and low birth weight while adjusting for possible confounders. The prevalence of intimate partner violence during pregnancy was 7.3% and the prevalence of low birth weight and preterm birth were 18.5% and 10.8% respectively. There was a statistically significant association between exposure to intimate partner violence during pregnancy and low birth weight. After adjustment for socioeconomic status, women’s habits and obstetric factors, the pregnant women who were exposed to intimate partner violence during pregnancy were two times more likely to have a child with a low birth weight (2.39 (95% CI: 1.26–4.55)). The prevalence of intimate partner violence during pregnancy, low birth weight, and preterm birth in this study was high. Women who experienced intimate partner violence during pregnancy had an increased risk of low birth weight. These findings justify a call to the federal minster of health to take measures aimed at avoiding intimate partner violence during pregnancy to reduce adverse birth outcomes.
Outcomes in very elderly ICU patients surgically treated for proximal femur fractures
Authors: Heuer Annika , Müller Jakob , Strahl André , Fensky Florian , Daniels Rikus , Theile Pauline , Frosch Karl-Heinz , Kluge Stefan , Hubert Jan , Thiesen Darius , Roedl Kevin 
Published: January 2024

AbstractProximal femur fractures (PFF) are a common injury in elderly patients that significantly impact mobility and daily living activities. Mortality rates in this population are also high, making effective treatment essential. Recent advances in intensive and geriatric care have enabled complex surgical interventions that were previously not feasible. However, there is a lack of studies focusing on outcome parameters in very elderly patients (≥ 90 years) who receive intensive care treatment following PFFs. In this retrospective study, we analyzed multi-layered data of 148 patients who were 90 years or older and received intensive care after trauma and orthopedic surgical treatment for PFFs or periprosthetic fractures between 2009 and 2019. All patients received a 365-day follow-up. To identify potential predictors of mortality, all deceased and surviving patients were subjected to multiple logistic regression analyses. We found that 22% of patients deceased during in-hospital care, and one-year survival was 44%. Independent predictors of one-year all-cause mortality included higher CCI and SOFA scores at ICU admission. Overall, 53% of patients who resided in private dwellings prior to admission were able to return home. Our study highlights the utility of using CCI and SOFA scores at ICU admission as prognostic indicators in critically ill very elderly patients who undergo surgical treatment for PFFs. These scores can provide valuable insight into the severity of illness and potential outcomes, which can inform resource allocation, prioritize endangered patients, and aid in end-of-life discussions and planning with patients and their families. Our findings can help improve the management of PFFs in very elderly patients and contribute to optimized patient care.
Selective ensemble method for anomaly detection based on parallel learning
Authors: Liu Yansong , Zhu Li , Ding Lei , Huang Zifeng , Sui He , Wang Shuang , Song Yuedong 
Published: January 2024

AbstractAnomaly detection is a highly important task in the field of data analysis. Traditional anomaly detection approaches often strongly depend on data size, structure and features, while introducing the idea of ensemble into anomaly detection can greatly improve the generalization ability. Ensemble-based anomaly detection methods still face some challenges, however, such as data imbalance, time and space demand and the selection of base detectors. To this end, we propose a selective ensemble method for anomaly detection based on parallel learning (SEAD-PL). First, a differentiated stratified sampling method is designed to alleviate the problem of data imbalance. Then, a distributed parallel training frame is built to address the problem of excessive time and space consumption for base detector training. Finally, a clustering-based ensemble selection strategy is introduced to balance the accuracy and diversity of base detectors. Experiments are performed on six datasets, which demonstrate that the proposed method has obvious advantages over four selected methods.
Optimization of table tennis target detection algorithm guided by multi-scale feature fusion of deep learning
Authors: Rong Zhang 
Published: January 2024

AbstractThis paper aims to propose a table tennis target detection (TD) method based on deep learning (DL) and multi-scale feature fusion (MFF) to improve the detection accuracy of the ball in table tennis competition, optimize the training process of athletes, and improve the technical level. In this paper, DL technology is used to improve the accuracy of table tennis TD through MFF guidance. Initially, based on the FAST Region-based Convolutional Neural Network (FAST R-CNN), the TD is carried out in the table tennis match. Then, through the method of MFF guidance, different levels of feature information are fused, which improves the accuracy of TD. Through the experimental verification on the test set, it is found that the mean Average Precision (mAP) value of the target detection algorithm (TDA) proposed here reaches 87.3%, which is obviously superior to other TDAs and has higher robustness. The DL TDA combined with the proposed MFF can be applied to various detection fields and can help the application of TD in real life.
Proton-FLASH: effects of ultra-high dose rate irradiation on an in-vivo mouse ear model
Authors: Rudigkeit Sarah , Schmid Thomas E. , Dombrowsky Annique C. , Stolz Jessica , Bartzsch Stefan , Chen Ce-Belle , Matejka Nicole , Sammer Matthias , Bergmaier Andreas , Dollinger Günther , Reindl Judith 
Published: January 2024

AbstractFLASH-radiotherapy may provide significant sparing of healthy tissue through ultra-high dose rates in protons, electrons, and x-rays while maintaining the tumor control. Key factors for the FLASH effect might be oxygen depletion, the immune system, and the irradiated blood volume, but none could be fully confirmed yet. Therefore, further investigations are necessary. We investigated the protective (tissue sparing) effect of FLASH in proton treatment using an in-vivo mouse ear model. The right ears of Balb/c mice were irradiated with 20 MeV protons at the ion microprobe SNAKE in Garching near Munich by using three dose rates (Conv = 0.06 Gy/s, Flash9 = 9.3 Gy/s and Flash930 = 930 Gy/s) at a total dose of 23 Gy or 33 Gy. The ear thickness, desquamation, and erythema combined in an inflammation score were measured for 180 days. The cytokines TGF-β1, TNF-α, IL1α, and IL1β were analyzed in the blood sampled in the first 4 weeks and at termination day. No differences in inflammation reactions were visible in the 23 Gy group for the different dose rates. In the 33 Gy group, the ear swelling and the inflammation score for Flash9 was reduced by (57 ± 12) % and (67 ± 17) % and for Flash930 by (40 ± 13) % and (50 ± 17) % compared to the Conv dose rate. No changes in the cytokines in the blood could be measured. However, an estimation of the irradiated blood volume demonstrates, that 100-times more blood is irradiated when using Conv compared to using Flash9 or Flash930. This indicates that blood might play a role in the underlying mechanisms in the protective effect of FLASH.
Radiation effect on stagnation point flow of Casson nanofluid past a stretching plate/cylinder
Authors: Mahabaleshwar U. S. , Maranna T. , Mishra Manoranjan , Hatami M. , Sunden Bengt 
Published: January 2024

AbstractThe exclusive behaviour of nanofluid has been actively emphasized due to the determination of improved thermal efficiency. Hence, the aim of this study is to highlight the laminar boundary layer axisymmetric stagnation point flow of Casson nanofluid past a stretching plate/cylinder under the influence of thermal radiation and suction/injection. Nanofluid comprises water andFe3O4as nanoparticles. In this article, a novel casson nanofluid model has been developed and studied on stretchable flat plate or circular cylinder. Adequate rational assumptions (velocity components) are employed for the transformation of the governing partial-differential equations into a group of non-dimensional ordinary-differential formulas, which are then solved analytically. The momentum and energy equations are solved through the complementary error function method and scaling quantities. Using various figures, the effects of essential factors on the nanofluid flow, heat transportation, and Nusselt number, are determined and explored. From obtained results, it is observed that the velocity field diminishes owing to magnification in stretching parameter$$B$$Band Casson fluid parameter$$\Lambda$$Λ. The temperature field increases by amplifying radiation$$N_{r}$$Nr, and solid volume fraction parameter$$\phi$$ϕ. The research is applicable to developing procedures for electric-conductive nanomaterials, which have potential applications in aircraft, smart coating transport phenomena, industry, engineering, and other sectors.
Tumefactive demyelinating lesions: a retrospective cohort study in Thailand
Authors: Ongphichetmetha Tatchaporn , Aungsumart Saharat , Siritho Sasitorn , Apiwattanakul Metha , Tanboon Jantima , Rattanathamsakul Natthapon , Prayoonwiwat Naraporn , Jitprapaikulsan Jiraporn 
Published: January 2024

AbstractTumefactive demyelinating lesions (TDL), characterized by large (≥ 2 cm) demyelinating lesions mimicking tumors, are a rare manifestation of the central nervous system inflammatory demyelinating diseases (CNS-IDD). Distinguishing TDL from other brain lesions can be challenging, often necessitating biopsy or advanced diagnostics. The natural history of TDL varies among races. This study aimed to assess demographics, clinical and radiological features, laboratory findings, management, and outcomes of Thai patients with TDL. We retrospectively reviewed records of twenty-six patients with TDL from the Multiple Sclerosis and Related Disorders registry from two tertiary medical centers. Among 1102 CNS-IDD patients, 26 (2.4%) had TDL. The median age at TDLs onset was 34.5 years (range 17–75); 69.2% were female. Over 70% manifested TDL as their initial CNS-IDD presentation. Common presenting symptoms included motor deficits, sensory disturbances, and cognitive problems. About two-fifths exhibited multiple lesions, most frequently in the frontoparietal region (46.2%). Half of the patients showed an incomplete ring on post-contrast T1-weighted imaging, with peripheral diffusion-weighted imaging restriction in twenty-one patients. T2-hypointense rims were present in thirteen (56.5%) patients. Brain biopsy was performed in 12 cases (46.1%). Serum aquaporin-4 immunoglobulin was positive in 16.7% of tested (4/24) cases. Serum myelin oligodendrocyte glycoprotein immunoglobulin was negative in all thirteen patients tested. Twenty patients (76.9%) received intravenous corticosteroids for TDL attacks. After the median follow-up period of 48 months (range 6–300), 23.1% experienced CNS-IDD relapses. Median Expanded Disability Status Scale at TDL diagnosis was 4.3 (range 0.0–9.5), and improved to 3.0 (range 0.0–10.0) at the last follow-up. This study suggested that TDL were rare among Thai CNS-IDD patients, frequently presenting as a monophasic condition with a favorable outcome.
Attention influences the effects of the previous form orientation on the current motion direction estimation
Authors: Wang Si-Yu , Gong Xiu-Mei , Zhan Lin-Zhe , You Fan-Huan , Sun Qi 
Published: January 2024

AbstractRecent studies have found that the estimates of motion directions are biased toward the previous form orientations, showing serial dependence, and the serial dependence does not involve cognitive abilities. In the current study, we conducted two experiments to investigate whether and how attention—a cognitive ability—affected the serial dependence. The results showed that serial dependence was present in the current study, reproducing the previous findings. Importantly, when the attentional load reduced the reliability (i.e., estimation accuracy and precision) of previous form orientations (Experiment 1), the serial dependence decreased, meaning that the biases of motion direction estimates toward previous form orientations were reduced; in contrast, when the attentional load reduced the reliability of current motion directions (Experiment 2), the serial dependence increased, meaning that the biases of motion direction estimates toward previous form orientations were increased. These trends were well consistent with the prediction of the Bayesian inference theory. Therefore, the current study revealed the involvement of attention in the serial dependence of current motion direction estimation on the previous form orientation, demonstrating that the serial dependence was cognitive and the attentional effect can be a Bayesian inference process, initially revealing its computational mechanism.
FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis
Authors: Ursic-Bedoya José , Desandré Guillaume , Chavey Carine , Marie Pauline , Polizzi Arnaud , Rivière Benjamin , Guillou Hervé , Assenat Eric , Hibner Urszula , Gregoire Damien 
Published: January 2024

AbstractFGF19 hormone has pleiotropic metabolic functions, including the modulation of insulin sensitivity, glucose/lipid metabolism and energy homeostasis. On top of its physiological metabolic role, FGF19 has been identified as a potentially targetable oncogenic driver, notably in hepatocellular carcinoma (HCC). Nevertheless, FGF19 remained an attractive candidate for treatment of metabolic disease, prompting the development of analogs uncoupling its metabolic and tumor-promoting activities. Using pre-clinical mice models of somatic mutation driven HCC, we assessed the oncogenicity of FGF19 in combination with frequent HCC tumorigenic alterations: p53 inactivation, CTNNB1 mutation, CCND1 or MYC overexpression. Our data revealed a strong oncogenic cooperation between FGF19 and MYC. Most importantly, we show that this oncogenic synergy is conserved with a FGF19-analog Aldafermin (NGM282), designed to solely mimic the hormone’s metabolic functions. In particular, even a short systemic treatment with recombinant proteins triggered rapid appearance of proliferative foci of MYC-expressing hepatocytes. The fact that FGF19 analog Aldafermin is not fully devoid of the hormone’s oncogenic properties raises concerns in the context of its potential use for patients with damaged, mutation-prone liver.
Go Team Go! Interprofessional Practice for Pediatric Feeding in the Schools
Authors: Dawson Michelle L. W. , Neal Angie , West Kristen 
Published: January 2024

Purpose:
The purpose of this clinical focus article is to discuss processes and procedures for building school-based programs to address the feeding and swallowing needs of students in the public-school setting. Interprofessional practice (IPP) team member roles and responsibilities, screening, eligibility, considerations for developing Individualized Education Programs that address the needs of students with pediatric feeding disorder (PFD) and dysphagia, as well as billing documentation requirements, are discussed. Additionally, coordination across the continuum of service delivery for students with PFD and dysphagia is investigated. Guidance on documentation, processes, and procedures that comply with the Individuals with Disabilities Education Act mandates will be provided.

Conclusions:
This clinical focus article will demonstrate that students with PFD and dysphagia continue to present to public schools and require skilled services and supports in order to meet their individualized needs. School-based speech-language pathologists have a legal requirement to provide these supports when deemed educationally relevant. Schools must employ processes and procedures that result in the timely and effective evaluation and identification of students with PFD and dysphagia. An IPP approach to the management of PFD and dysphagia is critical to ensure optimal outcomes for students found eligible for services.