bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of Prognostic Molecular Markers and Establishment of Prognostic Model for G-protein Coupled Receptor-Related Genes in Epithelial Ovarian Serous Cancer Based on Machine Learning Method
Authors: Ma Shaohan , Li Ruyue , Li Guangqi , Wei Meng , Li YongMei , Li Bowei , Ha Chunfang 
Published: October 2023

Abstract
Background. Ovarian cancer（OV） is one of the most common malignant tumors of the female reproductive system, five-year survival rate is in the low to mid 30% range, threatening the lives of female patients worldwide. Inefficient early diagnosis and prognostic prediction of OV leads to poor survival in most patients. G protein-coupled receptors (GPCRs) are currently the largest family of cell-surface receptors within the human genome are associated with OV. We aimed to identify G protein-coupled receptor-related genes GPCRRGs signatures and develop a novel model for predicting OV prognosis.
Methods.We downloaded data from The Cancer Genome Atlas (TCGA), and Gene Expression Omnibus (GEO) databases. Prognostic GPCRRGs were screened by Least absolute shrinkage and selection operator (LASSO)-Cox regression analysis, and a prognostic model was constructed. The model’s predictive ability was evaluated by Kaplan–Meier (K-M) survival analysis. The expression levels of these GPCRRGs included in the model were examined in normal and OV cell lines using quantitative reverse transcriptase polymerase chain reaction. We finally analyzed the immunological characteristics of the prognostic diagnostic model for differences between high and low risk groups using two methods: single-sample gene-set enrichment analysis（ssGSEA）and （CIBERSORT）.
Results. We screened a total of 17 GPCRRGs through TCGA and GEO databases. The K-M analysis showed that the prognostic model was able to significantly distinguish between high- and low-risk groups, corresponding to worse and better prognoses. M0 Macrophages , M2 Macrophages , Monocytes, Neutrophils, and T cells follicular helper have significant differences in the percentage of infiltration abundance among five types of cells. Immune cell infiltration, immune checkpoint expression levels, and Tumor Immune are also insightful for OV immunotherapy.
Conclusion. The prognostic model constructed in this study has potential for improving our understanding of GPCRRGs and providing a new tool for prognosis and immune response prediction in patients with OV.
Living with a "big illness" in Goa, India, unmaking and remaking of life-world: depression, stigma &amp; HIV in the HAART era
Authors: Mayston Rosie , Fernandes Luanna , Fernandes Danielle , Dias Amit , Prince Martin , Sequeira Miriam 
Published: October 2023

Abstract

Whilst advances in treatment mean that HIV is now characterised as a chronic disease where people living with the condition can achieve a “normal” life expectancy. However, it is questionable whether normalcy may be achieved in the context of the everyday life challenges that many of those living with HIV face. Unsurprisingly, depression is common. Despite clinical advances, people with HIV, particularly those living in some low and middle-income countries, including India, face pervasive stigma. We carried out a qualitative study in Goa, India to explore how people living with HIV and NGO service providers make sense of the disease. We were particularly interested in the psychosocial experience of living with HIV. We used purposive and snowball sampling to recruit HIV NGO service providers (n = 18) and service users (n = 19). In-depth interviews were carried out by trained research assistants in local languages (Konkani/Hindi/English) between May to August 2020. We used thematic analysis, starting with inductive coding carried out by two researchers and moving to collaborative generation and refinement of themes. Our results show that for our participants, HIV retained its disruptive power. Although lack of knowledge about treatment contributed to distress, it was the social effects (stigma) that were most feared, leading some to consider suicide. Our narratives illustrated an arc from unmaking to reconstitution of the lifeworld. This was achieved by focusing on enduring threads (faith in God, childrearing) and with the support and guidance of NGO staff, many of whom were living with HIV themselves. Our findings suggest the social constitution of depression and its entanglement with stigma among people living with HIV. There may be a critical time-point close to diagnosis for dual interventions which address both these life problems, which may have positive effects on HIV outcomes. NGOs and peers may be the natural homes/hosts for these.
A neutron diffraction study of the hydrous borate inderborite, CaMg[B3O3(OH)5]2(H2O)4·2H2O
Authors: Gatta G. Diego , Cannaò Enrico , Comboni Davide , Battiston Tommaso , Fabelo Oscar 
Published: October 2023

Abstract
The crystal chemistry of inderborite, a B-rich mineral (B2O3 ~41 wt%) with ideal formula CaMg[B3O3(OH)5]2·6H2O or CaMg[B3O3(OH)5]2(H2O)4·2H2O from the Inder Deposit, Kazakhstan, was re-investigated by a multi-methodological approach (single-crystal X-ray and neutron diffraction, electron probe micro-analysis in wavelength-dispersive mode, laser ablation multi-collector inductively mass spectrometry). The experimental findings show that the real chemical formula of inderborite from the Inder Deposit is virtually identical to the ideal one: the fraction of potential isomorphic substituents is insignificant. Boron is, therefore, the only industrially relevant element occurring in this mineral. The in situ B isotope composition of the Inder inderborite shows enrichment in the heavy 11B isotope, giving a weighted mean δ11BNIST951 of +35.15 ± 0.49 ‰ (2σ, N = 6). Such a positive δ11B value falls within the range of values in which the source of boron is ascribable to marine reservoirs rather than to terrestrial ones.
X-ray (at 293 K) and neutron (at 20 K) structure refinements confirm that the principal building block unit of the structure is a [B3O3(OH)5]2– ring, consisting of two BO2(OH)2 tetrahedra (B-ion in sp3 electronic configuration) and one planar-triangular BO2OH group (B-ion in sp2 electronic configuration). In the [B3O3(OH)5]2– ring, all the oxygen atoms that are not shared between two boron atoms are protonated. The building units share corners with the CaO2(OH)4(OH2)2 polyhedra and Mg(OH)4(OH2)2 octahedra, forming hetero-polyhedral sheets parallel to (100). Subsequent hetero-polyhedral sheets are mutually connected only by H-bonding interactions, even mediated by the zeolitic (“interstitial”) H2O molecules. Ten out of 11 independent oxygen sites in the structure of inderborite are involved in H-bonds as donors or acceptors, and this reflects the pervasive effect of the H-bonding network. The role played by the complex H-bond network is expected to be substantial on the stability of the crystalline edifice, having effects within the single hetero-polyhedral sheet, between subsequent sheets, and in the bonding with the interstitial zeolitic H2O molecules. Finally, the potential utilizations of inderborite, as a B-bearing mineral, are discussed.
PROSODIC CHARACTERISTICS OF ACOUSTIC SIGNAL IN SERBIAN AND EMOTION RECOGNITION
Authors: Kuruzović Nikolina , Đorić Valentina , Novakov Ivana 
Published: October 2023

The study focuses on the process of emotional recognition based on prosodic characteristics of acoustic signal in Serbian. Its main objective is to answer the question of the success of prosodic recognition of several emotions in Serbian. Furthermore, it explores whether the success in recognizing emotions in Serbian varies with regards to the following variables: the type of emotion, gender and the type of sentence. A total of 25 participants of average age around 23 participated in the study. The data was created by using Praat software for speech analysis. The results show general success in recognizing emotions on the level of M=12.43 (SD= 6.11). The participants were the most successful in recognizing the emotion of happiness, and the least successful in recognizing sadness. Post hoc analysis found a statistically significant difference in recognizing happiness and emotions of the negative spectrum (sadness, boredom, anger and fear). The results are discussed from the point of social functions of emotions, as well as the characteristics of the affective prosody in Serbian, with recognition of inevitable methodological limitations.
THE GEOLOGY-BASED METAPHOR AND ITS INVERSE FORM
Authors: Beko Lidija , Đorđević Marija 
Published: October 2023

This paper deals with the use of the geology-based metaphor in common and field -specific English, while including the concept of the “inverse metaphor” [1] which has proven highly important for specific vocabulary learning and initial understanding. The geology-based metaphor proves to have great potential for practical application in L2 vocabulary teaching, especially when it comes to explaining new field-specific terms. The paper is divided into several sections, the first one being a general introduction to the fields of metaphor and its relation to the language of science, as well as its usage in L2 vocabulary teaching. The second part deals with the typology of the geology-based metaphor and the specificities of the metaphor itself, whereas the third part focuses on a phenomenon noticed in our teaching practice at the Faculty of Mining and Geology which has been termed “inverse metaphor” in the study of the theory of metaphor. The last section explains our views on the importance of using the geology-based metaphor known from everyday English in the language classroom, alongside final conclusions, and remarks. This paper will hopefully provide more insight into the full capacity of the applicability of the geology-based metaphor.[1] The phenomenon in question has been termed differently by different authors, but we have opted for the term “inverse metaphor” from the paper “On Metaphoric Inversion” (1993) by Paul D. Deane, since it best describes what we have seen in our practice.
Europa's influence on the Jovian energetic electron environment as observed by Juno's micro Advanced Stellar Compass
Authors: Herceg Matija , Jorgensen John L , Denver Troelz , Jorgensen Peter S , Benn Mathias , Connerney John E. P. , Fléron René , Bolton Scott J , Mauk Barry H. 
Published: October 2023

The micro Advanced Stellar Compass is an attitude reference used for the
MAG investigation onboard Juno. The µASC camera head unit images the
star field with a CCD that is also sensitive to particles with enough
energy to pass through the camera shielding: electrons with energy
> 15 MeV and protons with energy > 80MeV. This
provides the capability to monitor fluxes of high-energy particles in
Jupiter’s magnetosphere, as the Juno has done since orbit insertion.
A survey of energetic electron fluxes sampled during the first 47 Juno
orbits reveals instances of variations observed when Juno is traversing
the M-shell of the Galilean moons. However, Juno’s traversal of the
Europa M-shell often results in distinctly different particle signatures
from that observed of the other moons. We present energetic particle
signatures related to the interaction with Europa and discuss the
implications for Europa as a sink and source for charged particles.
A Randomized Trial of Closed-Loop Insulin Delivery Postpartum in Type 1 Diabetes
Authors: Donovan Lois E. , Feig Denice S. , Lemieux Patricia , Murphy Helen R. , Bell Rhonda C. , Sigal Ronald J. , Ho Josephine , Virtanen Heidi , Crawford Susan , Yamamoto Jennifer M. 
Published: October 2023

OBJECTIVEThis study aimed to evaluate the efficacy of closed-loop insulin delivery postpartum.RESEARCH DESIGN AND METHODSIn this open-label, randomized controlled trial, postpartum individuals with type 1 diabetes were randomized to hybrid closed-loop insulin delivery with the MiniMed 670G/770G system in automode or sensor-augmented pump therapy in the first 12-weeks postpartum followed by a continuation phase with closed-loop insulin delivery for all until 24 weeks postpartum.RESULTSEighteen participants (mean ± SD age 32 ± 3.5 years, diabetes duration 22 ± 7.3 years, and early pregnancy HbA1c 52 ± 6.8 mmol/mol [6.9 ± 0.9%]) completed 24 weeks of postpartum follow-up. In the randomized phase, percent time in range 70–180 mg/dL (3.9–10 mmol/L) did not differ between groups (79.2 ± 8.7% vs. 78.2 ± 6.0%; P = 0.41). Participants randomized to closed-loop insulin delivery spent less time &lt;70 mg/dL (3.9 mmol/L) and &lt;54 mg/dL (3.0 mmol/L) (1.7 ± 0.8% vs. 5.5 ± 3.3% [P &lt; 0.001] and 0.3 ± 0.2% vs. 1.1 ± 0.9% [P = 0.008]). Time &gt;180 mg/dL (10 mmol/L) was not different between groups (18.7 ± 8.8% vs. 15.9 ± 7.7%; P = 0.21). In the continuation phase, those initially randomized to sensor-augmented pump therapy had less time &lt;70 mg/dL after initiation of closed-loop insulin delivery (5.5 ± 3.3% vs. 3.3 ± 2.2%; P = 0.039). The closed-loop group maintained similar glycemic metrics in both study phases. There were no episodes of diabetic ketoacidosis or severe hypoglycemia in the randomized or continuation phase in either group.CONCLUSIONSWomen randomized to closed-loop insulin delivery postpartum had less hypoglycemia than those randomized to sensor-augmented pump therapy. There were no safety concerns. These findings are reassuring for use of closed-loop insulin delivery postpartum because of its potential to reduce hypoglycemia.
Predictors of ≥15% Weight Reduction and Associated Changes in Cardiometabolic Risk Factors With Tirzepatide in Adults With Type 2 Diabetes in SURPASS 1–4
Authors: Małecki Maciej T. , Batterham Rachel L. , Sattar Naveed , Levine Joshua A. , Rodríguez Ángel , Bergman Brandon K. , Wang Hui , Ghimpeteanu Gabriela , Lee Clare J. 
Published: October 2023

OBJECTIVE
To identify predictors of body weight (BW) reduction of ≥15% with tirzepatide treatment and to describe associated clinical parameters of participants with type 2 diabetes (T2D) who achieved different categorical measures of BW reduction (&lt;5%, ≥5 to &lt;10%, ≥10 to &lt;15%, and ≥15%) across four studies from the phase 3 SURPASS clinical trial program for T2D.

RESEARCH DESIGN AND METHODS
The multivariate model for predictor of a BW reduction of ≥15% included age, sex, race, BW, HbA1c, tirzepatide dose and baseline metformin use, fasting serum glucose, and non-HDL cholesterol. Baseline characteristics and change from baseline to week 40/42 for efficacy parameters were described and analyzed in treatment-adherent participants (≥75% doses administered and on treatment at week 40/42) receiving once weekly tirzepatide (5 mg, 10 mg, or 15 mg) (N = 3,188).

RESULTS
Factors significantly associated with achieving a BW reduction of ≥15% with tirzepatide were higher tirzepatide doses, female sex, White or Asian race, younger age, metformin background therapy, and lower HbA1c, fasting serum glucose, and non-HDL cholesterol at baseline. With higher categorical BW reduction, there were greater reductions in HbA1c, triglycerides, ALT, waist circumference, and blood pressure.

CONCLUSIONS
Baseline factors associated with a higher likelihood of achieving a BW reduction of ≥15% with tirzepatide were higher tirzepatide doses, female sex, White or Asian race, younger age, metformin background therapy, better glycemic status, and lower non-HDL cholesterol. With greater BW reduction, participants with T2D achieved larger improvements in glycemia and cardiometabolic risk parameters. These findings help inform which people with T2D are most likely to achieve greater BW reduction with improved cardiometabolic risk factors with tirzepatide.
Harvest Time Residues of Imidacloprid and Thiamethoxam in Black Gram
Authors: Srikanth N. , Ahmad Md. Abbas , Sahoo S. K. 
Published: October 2023

Imidacloprid and thiamethoxam insecticides have been important tools for controlling pests in black gram. The use of these pesticides on various crops has increased rapidly resulting the produce containing toxic residues from the application of these insecticides and in some cases the concentrations are above maximum residue limit. The prudent usage of synthetic insecticides resulted in secondary pest-outbreaks, resistance development, food, and ecosystem adulteration and so on which pose serious threat to human beings. However, food safety issues related to pesticide residues are important to consider with a food crop such as black gram which causes no harm to consumers and are permissible in domestic and international trade. Therefore, the objective of this study was to analyse harvest time residues of imidacloprid and thiamethoxam in black gram. The study was conducted during the summer season 2021 at Research Farm, Tirhut College of Agriculture, Dholi (Muzaffarpur)–Bihar. The crop (cultivar SML 613) was sown on February, 27, 2021. Insecticides were applied at 30 days after sowing which was followed by two successive sprays at 15 days intervals following the recommended dose of 25 g a.i. ha-1 for both the insecticides. Sample aliquots were analysed using HPLC (High Pressure Liquid Chromatography) equipped with Photo Diode–Array Detector (PDA). The sample taken at harvest with a pre–harvest interval (PHI) of 28 days did not reveal the residues of imidacloprid and thiamethoxam in black gram seeds at Limit of Quantification (LOQ) of 0.05 mg kg-1.
Analisis Konflik Pembangunan Menara BTS di Dusun Poton, Kabupaten Sleman: Peran Sosialisasi dan Partisipasi Warga
Authors: Susanto Tri Agus 
Published: October 2023

Sleman Smart Regency adalah Kabupaten Sleman yang cerdas dalam pengembangan dan pengelolaan berbagai sumber daya (alam, manusia, waktu, dan lainnya) untuk digunakan secara efektif dan efisien dengan memanfaatkan teknologi informasi dan komunikasi sehingga dapat memaksimalkan pelayanan publik serta mendukung pembangunan yang berkelanjutan. Sleman Smart Regency sesuai visi Kabupaten Sleman yaitu terwujudnya masyarakat Sleman yang lebih sejahtera, mandiri, berbudaya dan terintegrasinya sistem e-Government menuju Smart Regency. Pendirian ratusan menara telekomunikasi di Kabupaten Sleman dimaksudkan untuk mendukung Sleman sebagai Smart Regency. Metode penelitian yang digunakan kualitatif dengan menganalisis konflik pembangunan Menara BTS di Dusun Poton, Kabupaten Sleman melalui wawancara, observasi dan dokumentasi. Hasil penelitian menunjukan bahwa Pemerintah Kalurahan Sariharjo tidak menjalankan sosialisasi dengan baik kepada warga di radius terdampak ketika akan mendirikan Menara BTS. Ketiadaan sosialisasi dengan baik, yang ditandai dengan tidak adanya dialog, tidak mendapat dukungan warga, dan tidak menampung keinginan atau keberatan warga, menyebabkan banyak warga kurang atau tidak berpartisipasi bahkan menentang keberadaan tower telekomunikasi itu. Pemerintah Kalurahan Sariharjo dalam rangka mendukung Sleman Smart Regency telah melakukan tindakan kurang smart dengan melakukan kesengajaan atau membiarkan mereka yang menandatangani Surat Persetujuan Warga Dalam Radius separuhnya orang di luar warga dalam radius. Dukungan teknologi informasi yang terintegrasi dapat meningkatkan transparansi dan akuntabilitas pemerintah. Namun saat akan membangun infrastruktur untuk mendukung Sleman Smart Regency berupa Menara BTS, muncul anggapan dari sebagian warga bahwa Pemerintah Kalurahan Sariharjo kurang transparan dan akuntabel. Salah satu sumbernya adalah Pemerintah Kalurahan Sariharjo tidak menjelaskan secara rinci terkait berapa uang kompensasi yang mestinya diterima warga radius terdampak.
The Influence of Financial Literacy, Attitude toward Debt, Risk Perception, and Religiosity on Financial Satisfaction (Study on Bank Employees in East Java)
Authors: Wijayanti Risna , Cahyaningtyas Sindy Eka Yulianti , Ismayanti Niken Wahyu 
Published: October 2023

Purpose: to contribute to further research on the conceptualization of financial satisfaction as a specific individual satisfaction domain based on subjective behavioral studies using a judgment approach. Financial Satisfaction is mostly studied based on standard economic theory which uses an objective approach in determining individual satisfaction with their financial conditions such as income, socio-demography, socio-capital, and socio-economy. This research examines several subjective variables in the form of judgment and examines the integrated relationship between these variables such as financial literacy, risk perception, attitudes toward debt, and religiosity.
Method: The sample for this research was 100 bank employees in East Java using a random sampling method. The analysis technique used is SEM PLS.
Result: The results show that financial literacy influences financial satisfaction among bank employees in East Java. Likewise, attitudes toward debt and religiosity also show an influence on financial satisfaction. Meanwhile, risk perception has no effect on financial satisfaction among bank employees in East Java.
Unusual pattern of branches and ganglions of cervical sympathetic trunk- single case study with clinical implications
Authors: Mazurek Mateusz , Pioterek Oliwier , Drążyk Mateusz , Wanat Marta , Kozłowski Oskar , Domagała Zygmunt 
Published: October 2023

Abstract
During routine dissection for didactic purposes, we found unusual branching pattern of cervical sympathetic trunk. In our case cervical sympathetic trunk had not only superior, middle, and inferior ganglia, but also presented two more ganglia in its main course. One of accessory ganglia was identified to be vertebral ganglion and presented with vertebral loop. All three cardiac cervical nerves emerged from another, extravertebral ganglion, which was supplied from sympathetic trunk. We are convinced that variability of cervical sympathetic trunk is clinically significant in surgery of head, neck, and cervical spine as well as in anatomy education. Therefore, we present our case showing a possible variation of this structure.
Clinical anatomy of the sphenoid bone and its terminology
Authors: Chmielewski Piotr Paweł 
Published: October 2023

Abstract
The sphenoid bone, an unpaired, irregular, and pneumatic (air-filled) component of the neurocranium, is a clinically important landmark, particularly in surgery and radiology. This bone is often regarded as one of the most complex bones of the skull. This literature review aims to compile peer-reviewed articles concerning the anatomy of the sphenoid bone while briefly exploring its clinical relevance. The sphenoid bone consists of a centrally positioned body containing the sphenoidal sinus, as well as three pairs of processes projecting from the body, namely the greater wings, lesser wings, and pterygoid processes. The sphenoid is closely associated with five cranial nerves (CNs II, III, IV, V1, V2, and VI) and is adjacent to the pituitary gland. The cavernous sinus, housing the internal carotid artery, lies laterally to the body of the sphenoid. Various neurological conditions, such as injury, inflammation, vascular malformations, aneurysms, and tumors, can either directly impact the sphenoid or occur in close proximity to it. A comprehensive understanding of the anatomy of the sphenoid is indispensable for diagnosing and planning the treatment of these conditions. Therefore, a detailed knowledge of the anatomy of the head, including the sphenoid, is essential in clinical practice. It ensures accurate diagnoses, safe surgical procedures, and effective management of diverse conditions affecting the skull, sinuses, brain, and adjacent structures. Inaccuracies or errors in the diagnosis or treatment of such conditions can lead to adverse patient outcomes, including various complications and delayed management of serious neurological conditions.