bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote Patient-Reported Outcomes and Activity Monitoring to Improve Patient-Clinician Communication Regarding Symptoms and Functional Status: A Randomized Controlled Trial
Authors: Parikh Ravi B. , Schriver Emily , Ferrell William J. , Wakim Jonathan , Williamson Joelle , Khan Neda , Kopinsky Michael , Balachandran Mohan , Gabriel Peter E. , Schuchter Lynn M. , Patel Mitesh S. , Shulman Lawrence N. , Manz Christopher R. 
Published: October 2023

PURPOSE Routine collection of patient-generated health data (PGHD) may promote earlier recognition of symptomatic and functional decline. This trial assessed the impact of an intervention integrating remote PGHD collection with patient nudges on symptom and functional status understanding between patients with advanced cancer and their oncology team. METHODS This three-arm randomized controlled trial was conducted from November 19, 2020, to December 17, 2021, at a large tertiary oncology practice. We enrolled patients with stage IV GI and lung cancers undergoing chemotherapy. Over 6 months, patients in two intervention arms received PROStep—weekly text message–based symptom surveys and passive activity monitoring using a wearable accelerometer. PGHD were summarized in dashboards given to patients' oncology team before appointments. One intervention arm received an additional text-based active choice prompt to discuss worsening symptoms or functional status with their clinician. Control patients did not receive PROStep. The coprimary outcomes patient perceptions of oncology team symptom and functional understanding at 6 months were measured on a 1-5 Likert scale (5 = high understanding). RESULTS One hundred eight patients enrolled: 55% male, 81% White, and 77% had GI cancers. Patient-reported clinician understanding did not differ between control and intervention arms for symptoms (4.5 v 4.5; P = .87) or functional status (4.5 v 4.3; P = .31). In the intervention arms, combined patient adherence to weekly symptom reports and daily activity monitoring was 64% and 53%, respectively. Intervention patients in the PROStep versus PROStep + active choice arms reported low burden from wearing the accelerometer (mean burden [standard deviation], 2.7 [1.3] v 2.1 [1.3]; P = .15) and completing surveys (2.1 [1.2] v 1.9 [1.3]; P = .44). CONCLUSION Patients receiving PROStep reported high understanding of symptoms and functional status from their oncology team, although this did not differ from controls.
Fully automated point spread function analysis using PyCalibrate
Authors: Metz Jeremy , Gintoli Michele , Corbett Alexander David 
Published: October 2023

ABSTRACT
Reproducibility is severely limited if instrument performance is assumed rather than measured. Within optical microscopy, instrument performance is typically measured using sub-resolution fluorescent beads. However, the process is performed infrequently as it is requires time and suitably trained staff to acquire and then process the bead images. Analysis software still requires the manual entry of imaging parameters. Human error from repeatedly typing these parameters can significantly affect the outcome of the analysis, rendering the results less reproducible. To avoid this issue, PyCalibrate has been developed to fully automate the analysis of bead images. PyCalibrate can be accessed either by executing the Python code locally or via a user-friendly web portal to further improve accessibility when moving between locations and machines. PyCalibrate interfaces with the BioFormats library to make it compatible with a wide range of proprietary image formats. In this study, PyCalibrate analysis performance is directly compared with alternative free-access analysis software PSFj, MetroloJ QC and DayBook 3 and is demonstrated to have equivalent performance but without the need for user supervision.
Diathermy and bone sawing are high aerosol yield procedures
Authors: Hamilton Victoria , Sheikh Sadiyah , Szczepanska Alicja , Maskell Nick , Hamilton Fergus , Reid Jonathan P. , Bzdek Bryan R. , Murray James R. D. 
Published: October 2023

AimsOrthopaedic surgery uses many varied instruments with high-speed, high-impact, thermal energy and sometimes heavy instruments, all of which potentially result in aerosolization of contaminated blood, tissue, and bone, raising concerns for clinicians’ health. This study quantifies the aerosol exposure by measuring the number and size distribution of the particles reaching the lead surgeon during key orthopaedic operations.MethodsThe aerosol yield from 17 orthopaedic open surgeries (on the knee, hip, and shoulder) was recorded at the position of the lead surgeon using an Aerodynamic Particle Sizer (APS; 0.5 to 20 μm diameter particles) sampling at 1 s time resolution. Through timestamping, detected aerosol was attributed to specific procedures.ResultsDiathermy (electrocautery) and oscillating bone saw use had a high aerosol yield (> 100 particles detected per s) consistent with high exposure to aerosol in the respirable range (< 5 µm) for the lead surgeon. Pulsed lavage, reaming, osteotome use, and jig application/removal were medium aerosol yield (10 to 100 particles s-1). However, pulsed lavage aerosol was largely attributed to the saline jet, osteotome use was always brief, and jig application/removal had a large variability in the associated aerosol yield. Suctioning (with/without saline irrigation) had a low aerosol yield (< 10 particles s-1). Most surprisingly, other high-speed procedures, such as drilling and screwing, had low aerosol yields.ConclusionThis work suggests that additional precautions should be recommended for diathermy and bone sawing, such as enhanced personal protective equipment or the use of suction devices to reduce exposure.Cite this article: Bone Joint Res 2023;12(10):636–643.
Performance enhancement of LACO-OFDM BER and PAPR using a K-means algorithm for a VLC system
Authors: Mohd Nordin Junita , Abdalmunam Hameed Aymen , Safar Anuar , Nawawi Norizan 
Published: October 2023

Layered asymmetrical clipped optical-orthogonal frequency division multiplexing (LACO-OFDM) enhances spectral efficiency by mandating the use of a K-means algorithm in LACO-OFDM (KLACO-OFDM), which enables efficiency gains to nearly double by modulating odd and even subcarriers. The traditional receiver is not sufficiently sophisticated enough to exploit the full potential of LACO-OFDM, thereby restricting its performance. In this paper, a K-means algorithm was used to increase the spectral efficiency of LACO-OFDM by integrating machine learning to cluster the inward signal such that the original locations of the received constellations can be retrieved. A K-means algorithm is used for assigning the received constellation points into their clusters of the ordinary quadrature amplitude modulator constellation points. The new mathematical framework in the proposed scheme is structured to analyze the PAPR and BER performance of LACO-OFDM systems that have been derived. The K-means algorithm development in LACO-OFDM (KLACO-OFDM) has also reduced the intersymbol interference, hence improving the spectral efficiency of LACO-OFDM compared with the conventional system in visible light communication (VLC) systems. BER gains were about 1.2–1.6 dB at 10−3 BER value, which rises from 1.4 to 2 dB for a 10−4 BER value because a lower BER facilitates precise estimation.
Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study
Authors: Akwa Lady Gwendoline , Smith Lesley , Twiddy Maureen , Abt Grant , Garnett Claire , Oldham Melissa , Shahab Lion , Herbec Aleksandra 
Published: October 2023

IntroductionThe COVID-19 pandemic and attendant lockdowns have had a substantial negative effect on alcohol consumption and physical activity globally. Pre-pandemic evidence in the adult population suggests that higher levels of physical activity were associated with higher levels of drinking, but it is unclear how the pandemic may have affected this. Therefore, this study aims to assess the association between alcohol consumption and physical activity in a UK cohort established during the COVID-19 pandemic.MethodsAnalyses utilized data from the Health Behaviours during the COVID-19 pandemic (HEBECO) study involving 2,057 UK adults (≥18 years). Participants completed self-report measures of alcohol consumption [frequency, quantity, frequency of heavy episodic drinking (HED) and AUDIT-C score] and physical activity [moderate-vigorous physical activity (MVPA), frequency of muscle strengthening activity (MSA) and sedentary behaviour] between November 2020 and January 2021. Ordinal logistic regression models were conducted, adjusting for sociodemographic factors.ResultsFifteen percent of the sample reported abstinence from drinking. Overall, 23.4% of participants drank ≥4 times/week, 13.9% drank more than 6 units/single drinking occasion (HED), 7.5% reported HED daily/almost daily and 4.2% scored ≥11 on AUDIT-C. MSA 3 days/week compared with no MSA was significantly associated with higher odds of alcohol frequency [OR (95 CI%) = 1.41 (1.04–1.91)], quantity [OR (95 CI%) = 1.38 (1.02–1.87)], HED [OR (95 CI%) = 1.42 (1.05–1.94)] and possible dependence [OR (95 CI%) = 1.47 (1.05–2.06)]. The association of MVPA and sedentary behaviour with drinking measures was not significant (p>0.05).ConclusionIn contrast with previous research, MSA rather than aerobic physical activity was associated with increased alcohol consumption during the COVID-19 pandemic. It is conceivable that during lockdown while drinking was used as a coping strategy, limited opportunities for aerobic exercise made MSA a more convenient form of physical activity. To guide public health interventions, more research is required to examine the temporal relationship between different forms of physical activity and alcohol consumption.
Well-posedness and stability analysis for Timoshenko beam system with Coleman-Gurtin's and Gurtin-Pipkin's thermal laws
Authors: Mukiawa Soh Edwin 
Published: October 2023

Abstract
In this article, the effect of Coleman-Gurtin’s and Gurtin-Pipkin’s thermal laws on the displacement of a Timoshenko beam system with suspenders is studied. Using the existing semi-group theory and energy method, the existence and uniqueness of weak global solution, as well as a stability result without imposing any conditions on the coefficient parameters, are established.
Immunotherapeutic approaches for systemic lupus erythematosus: early overview and future potential
Authors: Huang Hongpeng 
Published: October 2023

Abstract
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Current SLE therapies include immunosuppressants, antimalarial drugs, non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroids, but these treatments can cause substantial toxicities to organs and may not be effective for all patients. In recent years, significant progress has been made in the treatment of SLE using immunotherapy, including Benlysta and Saphnelo. These advances in immunotherapy hold promise for SLE patients, providing new therapeutic options that may offer better clinical benefit and effectiveness. Simultaneously, several new biological therapies focusing on cytokines, peptides, targeted antibodies, and cell-based approaches are under clinical evaluation and have shown immense potential for the treatment of SLE. However, the complexity of SLE immunopathogenesis and disease heterogeneity present significant challenges in the development of effective immunological therapies. This review aims to discuss past experiences and understanding of diverse immunological targeting therapies for SLE and highlight future perspectives for the development of novel immunological therapies.
Ultrasensitive label-free miRNA-21 detection based on MXene-enhanced plasmonic lateral displacement measurement
Authors: Wang Yuye , Hu Yurui , Xie Ruibin , Zeng Qi , Hong Yanhang , Chen Xi , Zhang Pengcheng , Zeng Lin , Zhang Yi , Zeng Shuwen , Yang Hui 
Published: October 2023

Abstract
miRNAs are small non-coding RNA molecules which serve as promising biomarkers due to their important roles in the development and progression of various cancer types. The detection of miRNAs is of vital importance to the early-stage diagnostics and prognostics of multiple diseases. However, traditional detection strategies have faced some challenges owing to the intrinsic characteristics of miRNAs including small size, short sequence length, low concentration level and high sequence homology in complex real samples. To overcome these challenges, we proposed a MXene-enhanced plasmonic biosensor for real-time and label-free detection of miRNA. By utilizing MXene nanomaterial which possesses unique characteristics including large surface area and strong carrier confinement abilities, we tuned the absorption of our plasmonic sensing substrate to reach a “zero-reflection” state and induced an extremely sharp phase change at the resonance angle. Combined with the sensing mechanism based on phase-induced lateral displacement measurement, this MXene-enhanced plasmonic biosensor can achieve a much superior sensing performance compared to traditional SPR devices. Based on this biosensing scheme, the ultrasensitive detection of target miRNA with a detection limit down to 10 fM has been successfully demonstrated. More importantly, single-base mismatched miRNA can be easily distinguished from the target miRNA according to the sensing signal. Furthermore, our plasmonic biosensor is capable of detecting miRNA in complex media such as 100 % human serum samples without compromising the detection sensitivity. This MXene-enhanced plasmonic sensing scheme has the ability of detecting miRNAs with extremely low concentration levels in complex surrounding media without the need of introducing extra labels or amplification tags, which holds great potential in various biological applications and clinical diagnostics.
Differences in Various Strength Manifestations Between the Flat and Retracted Bench Press Variants: Are They Affected by Subjects' Experience or Strength Levels?
Authors: Piepoli Antonio , Miras-Moreno Sergio , Janicijevic Danica , Martínez-Amat Antonio , García-Ramos Amador 
Published: October 2023

Abstract
Piepoli, A, Miras-Moreno, S, Janicijevic, D, Martínez-Amat, A, and García-Ramos, A. Differences in various strength manifestations between the flat and retracted bench press variants: are they affected by subjects' experience or strength levels? J Strength Cond Res XX(X): 000–000, 2023. The objective of this study was to explore the effect of retracting the scapulae during the free-weight bench press (BP) exercise on various strength manifestations and perceptual variables. Twenty-eight recreationally trained male lifters (BP 1-repetition maximum [1RM] = 96.1 ± 20.8 kg) randomly performed in 2 different sessions: the flat BP (scapulae free to move during the movement) and retracted BP (shoulders retracted during the movement). Three strength manifestations were evaluated: (a) explosive strength—mean velocity (MV) achieved against 3 submaximal loads (40, 60, and 80%1RM); (b) maximal strength—1RM; and (c) endurance strength—number of repetitions completed to failure against the 70%1RM. Discomfort and ratings of perceived exertion (RPE) values were also recorded immediately after completing each test. The upward displacement of the barbell was lower for the retracted BP compared with the flat BP at the 3 submaximal loads (p ≤ 0.024), but no significant differences between the BP variants were observed for the MV at submaximal loads (p ≥ 0.473), 1RM (p = 0.147), number of repetitions completed to failure (p = 0.447), RPE at submaximal loads (p ≥ 0.363), or discomfort during any test (p ≥ 0.611). Subjects always demonstrated a greater strength performance with the BP variant most used in their training programs, but the differences between the flat and retracted BP were not affected by subjects' maximal strength values (p ≥ 0.162). These results suggest that retracting the scapulae during the BP exercise presents minor effects on different strength manifestations and perceptual measures of effort and discomfort.
Associations Between Rank, Sex, and Parity With Musculoskeletal Injuries Sustained During Annual Military Physical Fitness Test
Authors: Edwards Chris Margaret , da Silva Danilo Fernandes , Puranda Jessica Laura , Souza Sara Carolina Scremin , Semeniuk Kevin , Adamo Kristi Bree 
Published: October 2023

Abstract
Edwards, CM, da Silva, DF, Puranda, JL, Souza, SCS, Semeniuk, K, and Adamo, KB. Associations between rank, sex, and parity with musculoskeletal injuries sustained during annual military physical fitness test. J Strength Cond Res 38(2): 367–373, 2024—Musculoskeletal injuries pose a significant threat to the well-being of military personnel. Attempts to use physical employment standard test results as predictors of injury are underway, but little is known about injuries sustained during the tests. This study sought to identify body regions most likely to be reported as injured during the annual Canadian Armed Forces (CAF) physical fitness evaluation. In addition, sex, rank, and parity status are explored as possible associated factors for injury. A total of 1,796 actively serving CAF members were categorized by sex (1,030 male participants; 766 female participants), rank (1,142 Non-Commissioned Members [NCM]; 638 Officers), and parity (314 parous female participants; 435 nulliparous female participants). Sex, rank, and parity were associated with body regions reportedly injured during an annual CAF fitness assessment (significance p ≤ 0.05). When compared with male participants, female participants were more likely to be injured {aOR: 1.797 (95% [confidence interval] CI: 1.45–2.23)} and more prone to injury of the wrist (adjusted odds ratio [aOR]: 1.933 [95% CI: 1.20–3.12]), hip (aOR: 3.445 [95% CI: 2.07–5.728]), or lower back (aOR: 1.55 [95% CI: 1.18–2.04]). Non-Commissioned Members were more likely to injure the neck (aOR: 2.14 [95% CI: 1.18–3.88]) or shoulder (aOR: 2.03 [95% CI: 1.31–3.15]), when compared with Officers. Parous female participants reported pelvis/abdomen injury at a higher rate than the nulliparous group (5 vs. 1.7%, p = 0.019). Injuries sustained during an annual CAF fitness assessment differ based on sex, rank, and parity. Canadian Armed Forces female participants, NCM, and parous female participants may require specific physical fitness support in preparation for the annual physical fitness test.
Shoulder and Scapular Muscle Activity During Low and High Plank Variations With Different Body-Weight-Bearing Statuses
Authors: Can Ezgi Nur , Harput Gulcan , Turgut Elif 
Published: October 2023

Abstract
Can, EN, Harput, G, and Turgut, E. Shoulder and scapular muscle activity during low and high plank variations with different body-weight-bearing statuses. J Strength Cond Res 38(2): 245–252, 2024—This study investigated the activation levels and activation ratios of shoulder and scapular muscles during low plank (LP) and high plank (HP) variations, with varying levels of body-mass support, including 4-point, 3-pod, and 2-point body-weight-bearing (BWB) statuses. The study was conducted with 21 healthy men (mean ± SD, 26 ± 6.5 years of age and 24.4 ± 2.4 kg·m−2 BMI). Ten different plank exercises were performed in a mixed order by changing elbow joint positions (LP and HP) and BWB statuses (2-point, 3-pod, and 4-point). Activation levels of the lower trapezius (LT), middle trapezius (MT), upper trapezius (UT), biceps brachii, triceps brachii, infraspinatus, and serratus anterior (SA) muscles were assessed with a surface electromyography device. Results of this study showed that elbow position changes resulted in higher LT (p = 0.01) and TB (p = 0.001) activation in HP exercises. In general, it was observed that an increase in BWB status was effective in increasing activation for the scapula and shoulder girdle muscles. The ratios of the UT muscle to the SA, LT, and MT muscles were less than 1 during side plank, bird dog, front reach, shoulder taps, and plank with shoulder external rotation exercises. High plank with toe touch exercise resulted in a marked increase in the UT activation. Therefore, it was concluded plank variations alter activation levels and activation ratios of shoulder and scapular muscles. Plank exercises may be used in shoulder rehabilitation and the progression in plank variations can be achieved by changing elbow position and BWB status based on individual requirements.
Selective Activation of Subthalamic Nucleus Output Quantitatively Scales Movements
Authors: Friedman Alexander D. , Yin Henry H. 
Published: October 2023

The subthalamic nucleus (STN) is a common target for deep brain stimulation (DBS) treatments of Parkinsonian motor symptoms. According to the dominant model, the STN output can suppress movement by enhancing inhibitory basal ganglia (BG) output via the indirect pathway, and disrupting STN output using DBS can restore movement in Parkinson's patients. But the mechanisms underlying STN DBS remain poorly understood, as previous studies usually relied on electrical stimulation, which cannot selectively target STN output neurons. Here, we selectively stimulated STN projection neurons using optogenetics and quantified behavior in male and female mice using 3D motion capture. STN stimulation resulted in movements with short latencies (10–15 ms). A single pulse of light was sufficient to generate movement, and there was a highly linear relationship between stimulation frequency and kinematic measures. Unilateral stimulation caused movement in the ipsiversive direction (toward the side of stimulation) and quantitatively determined head yaw and head roll, while stimulation of either STN raises the head (pitch). Bilateral stimulation does not cause turning but raised the head twice as high as unilateral stimulation of either STN. Optogenetic stimulation increased the firing rate of STN neurons in a frequency-dependent manner, and the increased firing is responsible for stimulation-induced movements. Finally, stimulation of the STN's projection to the brainstem mesencephalic locomotor region was sufficient to reproduce the behavioral effects of STN stimulation. These results question the common assumption that the STN suppresses movement, and instead suggest that STN output can precisely specify action parameters via direct projections to the brainstem.SIGNIFICANCE STATEMENTOur results question the common assumption that the subthalamic nucleus (STN) suppresses movement, and instead suggest that STN output can precisely specify action parameters via direct projections to the brainstem.