bluuebunny/crossref_metadata_2025_split huggingface dataset:
Types of organizational culture and sustainability in ecotourism businesses in southern Mexico
Authors: Medina-Álvarez Efraín , Sánchez-Medina Patricia S. 
Published: November 2023

PurposeThe purpose of this paper is to contribute to the understanding of the relationship between different types of organizational culture (hierarchical, clan or group, market or rational and adhocratic) and sustainability through three dimensions (economic, environmental and social) in ecotourism businesses in Oaxaca and Chiapas, Mexico.Design/methodology/approachIn this research 80 questionnaires were administered in the form of face-to-face interviews to ecotourism business owners'. Through a discriminant analysis and the theoretical support of the competing values framework (CVF), the prevailing types of culture were identified, and their influence was analysed through a regression analysis.FindingsThe results show that ecotourism businesses which are driven by hierarchical culture tend to have a greater focus on economic sustainability, while those businesses with a market or rational culture show a positive and significant influence on environmental sustainability. Likewise, businesses with adhocratic culture achieve sustainability holistically; however, the data reveal that clan or group culture is not associated with social sustainability.Originality/valueThis study offers empirical research that explains the relationship between organizational culture and sustainability. Additionally, it contributes to the study of environmental management issues in the ecotourism sector.
Suspicious activity reporting in the United Kingdom and the United States: statutory obligations of auditors and optimal harvesting of information
Authors: Norton Simon D. 
Published: November 2023

Purpose
This study aims to evaluate the advantages and disadvantages of auditor mandatory suspicious activity reporting versus the exercise of professional judgement in the anti-money laundering regimes of the UK and the USA.

Design/methodology/approach
The research draws upon the following sources. Firstly, statistics provided by the UK National Crime Agency, 2019 (NCA) regarding suspicious activity report (SAR) filing rates. Secondly, anti-money laundering legislation in the USA and UK. Thirdly, statements made in the political domain in the USA, particularly those which raised constitutional concerns during the progress of the Patriot Act 2001. Finally, statements and recommendations by a UK Parliamentary Commission enquiring into the effectiveness of the suspicious activity reporting regime.

Findings
The UK reporting regime does not accommodate professional judgement, resulting in the filing of SARs with limited intelligence value. This contrasts with discretionary reporting in the USA: voluntary reporting guides and influences auditor behaviour rather than mandating it. Defensive filing by UK auditors (defence to anti-money launderings [DAMLs]) has increased in recent years but the number of SARs filed has declined.

Originality/value
The study evaluates auditor behavioural responses to legislative regimes which mandate or alternatively accommodate discretion in the reporting suspicion of money laundering. Consideration of constitutional and judicial activism in this context is a novel contribution to the literature. For its theoretical framework the study uses Foucault’s concept of discipline of the self to evaluate auditor behaviour under both regimes.
Fall seven times, stand up eight: the neuropsychological and managerial configurations of resilience Configurations of resilience
Authors: Brenes Esteban R. , Rodriguez Gabriel , Murillo-Rojas Jorge-Vinicio , Pichardo Caleb A. 
Published: November 2023

Purpose
Resiliency is essential for achieving the necessary level of performance and ensuring the survival of a new business during difficult times. However, neither this characteristic nor its antecedents have been exhaustively studied. Using a configuration approach, this study aims to analyze the neuropsychological and business-related characteristics of entrepreneurs that may explain their resilience during the business development process.

Design/methodology/approach
Using the fuzzy set qualitative comparative analysis (fsQCA), the authors investigated distinct characteristics of Costa Rican agro-entrepreneurs with high levels of entrepreneurial resilience. The fsQCA methodology identifies combinations of causal measures that result in the outcome.

Findings
From the mixture of configurations, the authors found four combinations of individual’s characteristics that explain the profile of a resilient agro-entrepreneur.

Originality/value
This work contributes to the literature on agricultural entrepreneurship and entrepreneurial resilience. This study identifies four distinct combinations of entrepreneurs’ characteristics that produce entrepreneurial resilience in the agricultural industry. Moreover, it incorporates individuals’ business-related attributes into examining characteristics combinations that affect resilience. Also, this research offers agro-entrepreneurs’ stakeholders, valuable insights to develop more resilient entrepreneurs.
Effect of renin–angiotensin system inhibitors on cardiovascular events in hemodialysis patients with hyperphosphatemia: A post hoc analysis of the LANDMARK trial
Authors: Saito Yoshinori , Ito Hidetoshi , Fukagawa Masafumi , Akizawa Tadao , Kagimura Tatsuo , Yamamoto Masahiro , Kato Masanori , Ogata Hiroaki 
Published: November 2023

AbstractIntroductionThe clinical benefits of renin–angiotensin system inhibitors (RASi) in patients undergoing hemodialysis remain obscure.MethodsThis is a post hoc cohort analysis of the LANDMARK trial investigate whether RASi use was associated with cardiovascular events (CVEs) and all‐cause mortality. A total of 2135 patients at risk for vascular calcification were analyzed using a Cox proportional hazards model with propensity‐score matching.ResultsThe risk of CVEs was similar between participants with RASi use at baseline and those without RASi use at baseline and between participants with RASi use during the study period and those without RASi use during the study period. No clinical benefits of RASi use on all‐cause mortality were observed. Serum phosphate levels were significantly associated with the effect of RASi on CVEs.ConclusionsRASi use was not significantly associated with a lower risk of CVEs or all‐cause mortality in hemodialysis patients at risk of vascular calcification.
Bioaerosols in swine confinement buildings: A metaproteomic view
Authors: Meyer Susann , Hüttig Nicole , Zenk Marianne , Jäckel Udo , Pöther Dierk‐Christoph 
Published: November 2023

AbstractSwine confinement buildings represent workplaces with high biological air pollution. It is suspected that individual components of inhalable air are causatives of chronic respiratory disease that are regularly detected among workers. In order to understand the relationship between exposure and stress, it is necessary to study the components of bioaerosols in more detail. For this purpose, bioaerosols from pig barns were collected on quartz filters and analysed via a combinatorial approach of 16S rRNA amplicon sequencing and metaproteomics. The study reveals the presence of peptides from pigs, their feed and microorganisms. The proportion of fungal peptides detected is considered to be underrepresented compared to bacterial peptides. In addition, the metaproteomic workflow enabled functional predictions about the discovered peptides. Housekeeping proteins were found in particular, but also evidence for the presence of bacterial virulence factors (e.g., serralysin‐like metalloprotease) as well as plant (e.g., chitinase) and fungal allergens (e.g., alt a10). Metaproteomic analyses can thus be used to identify factors that may be relevant to the health of pig farmers. Accordingly, such studies could be used in the future to assess the adverse health potential of an occupationally relevant bioaerosol and help consider defined protective strategies for workers.
The future(s) of global governance: A scenarios exercise
Authors: Saz‐Carranza Angel , Rueda‐Sabater Enrique , Vandendriessche Marie , Moreno Carlota , Jordana Jacint 
Published: November 2023

AbstractPervasive uncertainty has stretched the fabric of global governance to its limit. The shape and form of future global governance is far from clear – yet we need to explore how it may play out, so that we can not only prepare for it but also overcome possible pernicious trajectories. Scenario thinking can be used to rigorously explore different possible outcomes. In this article, we present an exercise applying scenario thinking to global governance. These scenarios should help policymakers to understand which policies may or may not work in the diverse possible futures. They may also help policymakers to consider how their organisation, state, or institution could be affected if the global governance of a specific issue evolves in one direction or another. Civil society members or private companies may want to probe how robust their strategies would be in different global governance configurations. The article synthetically presents key contextual premises and uncertainties which are given as follows: four broad scenarios for the world in 2035; four corresponding scenarios for global governance; and scenarios for the global governance of four macro‐sectors: trade, security, climate change, and finance.
Successful management of postoperative tracheal metastasis in small cell lung cancer with radiotherapy and durvalumab: A case report
Authors: Sugiura Yasoo , Fujimoto Hiroyuki , Hashizume Toshinori 
Published: November 2023

AbstractThe patient in this report was a 73‐year‐old male who was diagnosed with small cell lung cancer (T3N0M0 stage IIB) after presenting with a 5.5 cm tumor detected in the right lower lobe of the lung by radiography. After right lower lobectomy and lymphadenectomy, postoperative adjuvant chemotherapy was administered with cisplatin and etoposide. At 27 months after surgery, the patient complained of wheezing. Tracheal metastasis was identified through computed tomography and bronchoscopy. Biopsy confirmed metastasis of small cell lung cancer. Radiotherapy (60 Gy) was administered to the mediastinal lymph nodes, including the supraclavicular region. The patient then underwent four cycles of carboplatin‐etoposide‐durvalumab, followed by durvalumab maintenance therapy. At 49 months after surgery, the patient complained of discomfort while speaking, leading to the discovery of a nodule in the subglottic space, which confirmed small cell lung cancer metastasis. Radiotherapy (30 Gy) was administered to the larynx and mediastinum, and the patient continued with durvalumab monotherapy. As of 61 months after surgery, he remains recurrence‐free after the second course of radiotherapy. Our favorable outcome could be explained by the synergy between immunotherapy and radiotherapy. Here, we report a rare case of postoperative tracheal metastasis in small cell lung cancer successfully managed with radiotherapy and durvalumab. This shows promise in achieving local disease control and extending survival in postoperative metastatic lesions, highlighting a potential therapeutic approach.
Miliary brain metastases from lung adenocarcinoma with EGFR (L858R) and CTNNB1 mutations
Authors: Kunishige Michihiro , Takeuchi Eiji 
Published: November 2023

AbstractA 76‐year‐old man was referred to our hospital with a cough. Chest computed tomography (CT) revealed a 45‐mm mass in the lingular segment of the left upper lobe. Transbronchial tumor biopsies showed adenocarcinoma. Contrast‐enhanced CT and bone scintigraphy revealed lung, pleura, and bone metastases. The patient was diagnosed with left upper lobe adenocarcinoma cT2bN3M1c stage IVB. A genetic analysis of the primary tumor using the Oncomine Dx Target Test Multi‐CDx system revealed positivity for epidermal growth factor receptor (EGFR) (L858R) and CTNNB1 mutations. Based on these findings, the patient was treated with osimertinib (80 mg/day) as first‐line therapy. Six months later, the tumor increased in size, indicating progressive disease. Osimertinib was stopped and second‐line therapy with carboplatin (area under the curve 5) and pemetrexed (500 mg/m2) was initiated. After three cycles of chemotherapy, the patient developed dementia and disorientation. Contrast‐enhanced magnetic resonance imaging of the head showed miliary brain metastases. Miliary dissemination is a rare form of brain metastasis. Miliary patterns of lung metastases have been strongly associated with the EGFR exon 19 deletion. The radiological features of miliary brain metastases of non‐small cell lung cancer with the exon 19 deletion have been reported. To the best of our knowledge, this is the first case report of lung cancer with miliary brain metastases and co‐mutations of EGFR (L858R) and CTNNB1. In conclusion, co‐mutations of EGFR (L858R) and CTNNB1 and the discontinuation of EGFR‐tyrosine kinase inhibitor may contribute to the development of miliary brain metastases. Further case studies are warranted.
MFSD2A frameshift variant in Kerry Hill sheep with microcephaly
Authors: Rudd Garces Gabriela , Letko Anna , Häfliger Irene M. , Müller Jana , Herden Christiane , Nesseler Anne , Wagner Henrik , Schmidt Martin J. , Drögemüller Cord , Lühken Gesine 
Published: November 2023

AbstractMicrocephaly is a rare neurodevelopmental disorder characterized by reduced skull circumference and brain volume that occurs sporadically in farm animals. We investigated an early‐onset neurodegenerative disorder observed in seven lambs of purebred Kerry Hill sheep. Clinical signs included inability to stand or severe ataxia, convulsions, and early death. Diagnostic imaging and brain necropsy confirmed microcephaly. The pedigree of the lambs suggested monogenic autosomal recessive inheritance. We sequenced the genome of one affected lamb, and comparison with 115 control genomes revealed a single private protein‐changing variant. This frameshift variant, MFSD2A: c.285dupA, p.(Asp96fs*9), represents a 1‐bp duplication predicted to truncate 80% of the open reading frame. MFSD2A is a transmembrane protein that is essential for maintaining blood–brain barrier homeostasis and plays a key role in regulating brain lipogenesis. Human MFSD2A pathogenic variants are associated with a neurodevelopmental disorder with progressive microcephaly, spasticity, and brain imaging abnormalities (NEDMISBA, OMIM 616486). Here we present evidence for the occurrence of a recessively inherited form of microcephaly in sheep due to a loss‐of‐function variant in MFSD2A (OMIA 002371‐9940). To the best of our knowledge, this is the first report of a spontaneous MFSD2A variant in domestic animals.
No trade‐off between growth and OsHV‐1 tolerance in Pacific oysters (Crassostrea gigas) farmed on the West Coast, USA
Authors: Divilov Konstantin , Schoolfield Blaine , Merz Noah , Langdon Chris 
Published: November 2023

AbstractAn important pathogen of concern for Pacific oyster growers in the USA is ostreid herpesvirus 1 (OsHV‐1). Currently, oyster stocks exist that are tolerant to OsHV‐1; however, it is uncertain if a trade‐off exists between their tolerance to OsHV‐1 and their growth in different environments. To investigate any potential trade‐offs, Pacific oyster families with varying levels of OsHV‐1 tolerance were grown in a bay where OsHV‐1 is endemic (Tomales Bay, CA) and in a bay where OsHV‐1 is absent (Willapa Bay, WA). In Tomales Bay, we found that oysters from OsHV‐1 tolerant families grew faster than oysters from OsHV‐1 susceptible families, while in Willapa Bay, no statistically significant difference in growth was found between oyster families with different levels of OsHV‐1 tolerance observed in Tomales Bay. These findings indicate that Pacific oysters bred to be tolerant to OsHV‐1 would not be expected to have a longer time‐to‐market regardless of the presence of OsHV‐1 in the growing environment.
Dermatological considerations for transgender and gender diverse patients: An Australian perspective
Authors: Gu Yaron , Tang Gia Toan , Cheung Ada Sau‐Zhuen , Sebaratnam Deshan Frank 
Published: November 2023

AbstractTransgender and gender diverse (TGD) individuals are a group that experiences significant health disparities. In the multidisciplinary management of TGD patients, dermatologists may participate in managing skin‐ and hair‐related issues which contribute to gender affirmation and to the cutaneous sequelae of gender‐affirming hormone therapy. This review aims to highlight the unique needs of TGD patients, particularly from the perspective of Australian dermatologists. We review appropriate terminology critical for TGD care, gender affirmation in the Australian healthcare landscape, dermatological considerations for TGD patients and considerations for management.
Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?
Authors: Cottrell Elizabeth C. 
Published: November 2023

AbstractHypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed. Substantial evidence from non‐pregnant subjects has demonstrated the potential for dietary nitrate supplementation to increase nitric oxide (NO) bioavailability and lower blood pressure, following bioactivation via the non‐canonical NO pathway. Emerging data suggest this approach may also be of benefit in pregnant women, although studies are limited. This review aims to summarise the current evidence from preclinical and clinical studies of nitrate supplementation in pregnancy, drawing on data from non‐pregnant populations where appropriate and highlighting key gaps in knowledge that remain to be addressed in future trials.
Sedimentary architecture of submarine lobes affected by bottom currents: Insights from the Rovuma Basin offshore East Africa
Authors: Chen Mei , Wu Shenghe , Wang Ruifeng , Zhang Jiajia , Xie Pengfei , Wang Min , Wang Xiaofeng , Xiong Qicong , Yu Jitao , Miramontes Elda 
Published: November 2023

AbstractThe influence of bottom currents on submarine channels has been widely recognized, for instance, by the formation of asymmetric channel‐levee systems and drifts. In contrast, it is often considered that submarine lobes can be only reworked by strong bottom currents and are not affected by bottom currents during their deposition. In this study, we analyse the potential effect of bottom currents on different hierarchical lobe architectures that formed during the lower Oligocene in the Rovuma Basin offshore East Africa. We characterize the stacking patterns, morphology and connectivity of different hierarchy lobes using well data and three‐dimensional seismic data. We found no direct influence of bottom currents on the lobe complexes and single lobes that show a unidirectional stacking pattern that is opposite to the direction of bottom currents. Lobe elements in single lobes display vertical accretion with no obvious relationship with bottom currents. Additionally, the first deposited single lobe morphology presents an asymmetric shape, with a thicker lobe margin on the downstream side of the bottom currents, but this is due to an initial low topography on the downstream side rather than bottom currents. The architectural distribution reflects that the topography present before the depositions of the submarine lobes was controlled by previous asymmetrical channel‐levee systems formed by the synchronous interaction of bottom currents and gravity flows. This asymmetric topography controls the subsequent deposition of lobes and results in the migration of single lobes in the upstream direction of bottom currents. Although weak to moderate bottom currents may not be able to substantially rework submarine lobes, our results demonstrate that they may control the geometry and evolution of submarine channels and thus indirectly affect the thickness and migration of lobes in more environments than previously thought.
Breast cancer and its therapeutic targets: A comprehensive review
Authors: Singh Ayushi , Mishra Rakhi , Mazumder Avijit 
Published: November 2023

AbstractBreast cancer is a common and deadly disease, so there is a constant need for research to find efficient targets and therapeutic approaches. Breast cancer can be classified on a molecular and histological base. Breast cancer can be divided into ER (estrogen receptor)‐positive and ER‐negative, HER2 (human epidermal growth factor receptor2)‐positive and HER2‐negative subtypes based on the presence of specific biomarkers. Targeting hormone receptors, such as the HER2, progesterone receptor (PR), and ER, is very significant and plays a vital role in the onset and progression of breast cancer. Endocrine treatments and HER2‐targeted drugs are examples of targeted therapies now being used against these receptors. Emerging immune‐based medicines with promising outcomes in the treatment of breast cancer include immune checkpoint inhibitors, cancer vaccines, and adoptive T‐cell therapy. It is also explored how immune cells and the tumor microenvironment affect breast cancer development and treatment response. The major biochemical pathways, signaling cascades, and DNA repair mechanisms that are involved in the development and progression of breast cancer, include the PI3K/AKT/mTOR system, the MAPK pathway, and others. These pathways are intended to be inhibited by a variety of targeted drugs, which are then delivered with the goal of restoring normal cellular function. This review aims to shed light on types of breast cancer with the summarization of different therapeutic approaches which can target different pathways for tailored medicines and better patient outcomes.
What starts with laughter ends in tears: Invasive alien species regulations should not hinder scientific research
Authors: Pietrzyk‐Kaszyńska Agata , Olszańska Agnieszka , Najberek Kamil , Maciaszek Rafał , Solarz Wojciech 
Published: November 2023

AbstractBiological invasions represent one of the major threats to the world's biodiversity. National and international efforts are taken to address the complexity and dynamic of invasions in legislation. However, based on the Polish experience of implementing the European Union's regulation on invasive alien species (IAS), we suggest that an unclear and disorganized process of law implementation results in the regulations being counterproductive. We describe how a well‐planned policy can become a burden impeding effective research and, consequently, scientific feedback to improve the policy. The results of our study suggest that there is a large scale of scientists' noncompliance with new legal requirements. For many researchers, the implementation of the new IAS regulation was changing the rules in the middle of the game. Researchers strictly following the new regulations must wait for the relevant permits and may risk the successful completion of their projects. Conversely, researchers who prioritize project completion may be forced to continue their research violating the law. We argue that this example of implementing the new IAS regulation illustrates the need to include some intermediate solutions providing more flexibility and time for researchers to adjust to policy change, thus minimizing the negative impacts of the new legislature on scientific progress.