bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in electroencephalogram power densities between genuine narcolepsy and secondary narcolepsy
Authors: Honma Hiroshi , Kohsaka Masako , Fukuda Noriko , Kobayashi Riko , Sakakibara Satoshi , Koyama Tsukasa 
Published: March 2003

AbstractDiagnosing narcolepsy is not always simple. Some patients secondarily show narcoleptic tetrad through irregular sleep patterns or psychotic diseases. The power densities of daytime electroencephalograms in genuine narcolepsy and secondary narcolepsy were analysed and compared. Electroencephalogram power densities for a 6.5‐h period after waking in genuine narcoleptic patients were lower than those of secondary narcoleptic patients in the 11.0–12.5 Hz bands. Arousal levels may be lower in genuine narcoleptic patients than in secondary narcoleptic patients. Spectral analysis may be useful in clarifying differences between the two groups.
Case of a non‐24 h sleep–wake syndrome patient improved by phototherapy
Authors: Watanabe Tsuyoshi , Kajimura Naofumi , Kato Masaaki , Sekimoto Masanori , Hori Toru , Takahashi Kiyohisa 
Published: March 2003

AbstractPolysomnography (PSG) and body temperature were examined in a patient with non‐24 h sleep–wake syndrome who responded to phototherapy. The patient was a 17‐year‐old male who had been suffering from a free‐running sleep–wake rhythm for 2 months. Phototherapy was administered to the patient while he was admitted to our hospital. This treatment immediately changed the free‐running sleep–wake and body temperature rhythm of the patient to the environmental 24‐h rhythm. On a polysomnography, total sleep time and stages 1 and 2 and REM sleep were decreased, and percentage stage 3 + 4 was increased by phototherapy. The time of minimum body temperature (mBT) was located at the latter half of the sleep phase through the clinical course of the patient.
Effects of phototherapy on the phase relationship between sleep and body temperature rhythm in a delayed sleep phase syndrome case
Authors: Hori Toru , Watanabe Tsuyoshi , Kajimura Naofumi , Kato Masaaki , Sekimoto Masanori , Takahashi Kiyohisa 
Published: March 2003

AbstractWe examined polysomnography (PSG) and body temperature of a patient with delayed sleep phase syndrome (DSPS) who was successfully treated with only phototherapy. This case showed a possible improvement of the phase relationship between sleep and body temperature rhythm given that the time of minimum body temperature (mBT) shifted to the latter portion of the sleep phase after constant phototherapy.
Reliability and validity of the Turkish version of the adolescent dissociative experiences scale
Authors: ZOROGLU SULEYMAN SALIH , SAR VEDAT , TUZUN UMRAN , TUTKUN HAMDI , SAVAS HALUK ASUMAN 
Published: March 2003

AbstractThe Adolescent Dissociative Experiences Scale (A‐DES) is designed to measure dissociation in adolescents. The present study aimed to assess the reliability, validity, and psychometric characteristics of the Turkish version of the A‐DES. The Turkish version of the A‐DES was administered to 20 patients with a dissociative disorder, 24 patients with post‐traumatic stress disorder (PTSD), 31 patients with anxiety disorder, 31 patients with mood disorder, 24 patients with attention deficit–hyperactivity disorder (ADHD), and 201 non‐clinical participants. The internal consistency and the test–retest correlation of the A‐DES were excellent. The mean total score of A‐DES was 6.2 in dissociative disorder, 3.9 in PTSD, 2.1 in anxiety disorder, 2.4 in mood disorder, 2.5 in ADHD groups and 2.4 in non‐clinical participants. There was a statistically significant difference between dissociative patients and other diagnostic groups on the A‐DES total score. The good psychometric characteristics of the A‐DES among Turkish participants support its cross‐cultural validity.
Incidence of P53 and K‐ras alterations in ovarian mucinous and serous tumors
Authors: Morita Katsuo , Ono Yuko , Fukui Hirokazu , Tomita Shigeki , Ueda Yoshihiko , Terano Akira , Fujimori Takahiro 
Published: March 2003

AbstractClarification of the pathogenic relationships existing among ovarian cystadenomas, tumors of low malignant potential (LMP) and various adenocarcinoma types, a series of 29 mucinous and 19 serous ovarian tumors including adenomas, LMP tumors and adenocarcinomas were examined. P53 protein was detected by the streptavidin–biotin method and point mutation of K‐ras codon 12 was detected by polymerase chain reaction‐restriction fragment length polymorphism analysis. P53 overexpression was observed more frequently in serous adenocarcinomas (5/8, 63%) than in mucinous adenocarcinomas (2/9, 22%) and was correlated with the malignant potential of serous tumors. Furthermore, the proportion of P53‐positive cells was significantly higher in serous adenocarcinomas than in mucinous adenocarcinomas. P53 overexpression may therefore be closely related to the early events of carcinogenesis in serous tumors. Although mutation of the K‐ras oncogene appears to be an important event in the early tumorigenesis of mucinous tumors, mutation of the K‐ras oncogene in serous tumors may be dependent on morphology. Different complex pathways of oncogene and/or tumor suppressor gene abnormalities may be involved in the development of mucinous and serous adenocarcinomas.
Amphidiniopsis uroensis sp. nov. and Amphidiniopsis pectinaria sp. nov. (Dinophyceae): Two new benthic dinoflage llates from Japan
Authors: Toriumi Saburo , Yoshimatsu Sadaaki , Dodge John D. 
Published: March 2003

SUMMARYTwo new armoured, heterotrophic sand‐dwelling marine dinoflagellates, Amphidiniopsis uroensis Toriumi, Yoshimatsu et Dodge sp. nov. and Amphidiniopsis pectinaria Toriumi, Yoshimatsu et Dodge sp. nov. were collected from Japanese sandy beaches, and their morphological features observed by light microscopy and scanning electron microscopy (SEM). The cell size of A. uroensis is 28–31 μm in length and 23–28 μm in width. The plate formula is Po 3′, 3a, 6″, 3c, 4s (+1 acc.), 5″′, 2″″. The thecal surface is ornamented with small processes, pores and spines, however, the surface of plate 2a is smooth. The epitheca possesses a narrow ridge that is extended along on the suture between 1′ and 3′. Plate 1″ connects with the right sulcal (Sd) and right sulcal accessory (Sda) plates, so the cingulum is incomplete. A nucleus is situated in the central part of the cell. There are a few small spines at the antapex. There are no stigma or chloroplasts. Amphidiniopsis pectinaria cells are 33–40 urn in length and 29–35 μm in width. The plate formula is Po 4′, 3a, 7″, 3c, 4s (+1 acc.), 5″′, 2″″. Plate 1″ connects directly with Sd and Sda plates, so the cingulum is incomplete. The thecal surface is ornamented with small processes, spines and pores. The epitheca is provided with a narrow ridge that is extended along on the suture between plates 1′, 4′ and 7″. The ornamentation on the antapical plates is unique. It is arranged in 10 straight rows on the hypotheca; each row has a strong spine at its posterior end. In addition, there is a long spine at the antapex. There are no stigma or chloroplasts. A nucleus is located in the central part of the cell.
A diary form quality of life questionnaire for Japanese patients with lung cancer and summarization techniques for longitudinal assessment
Authors: Ishihara Yoko , Sakai Hiroshi , Nukariya Naotaka , Kobayashi Kunihiko , Yoneda Shuichi , Matsuoka Rokuro , Hohjo Tadahiko , Nishiwaki Yutaka , Hoshi Akira , Kuratomi Yuhshiro , Nagai Atsushi , Kagawa Jun , Kitamura Satoshi 
Published: March 2003

The aim of this study was to confirm the validity and reliability of a new diary‐type quality of life (QOL) self‐rating questionnaire tailored for use by Japanese inpatients with lung cancer receiving chemotherapy. Two kinds of summary statistics were tested in QOL analysis.The questionnaire has a four‐scale structure; physical, psychological, daily activity and global scales. Fifty‐three patients were enrolled to test the reliability and validity. Summary statistics were assessed using indices of the area under the curve (AUC) and the maximum fluctuations of QOL scores (Dif max) in patients receiving cisplatin or carboplatin.The questionnaire had satisfactory reliability and validity. The physical, psychological and global scales scores changed to the worst levels after treatment, continuing for 1 week in the cisplatin group, whereas those of the carboplatin group began to worsen from day 3, but returned to pre‐ chemotherapy levels by day 9. The cisplatin group showed significant decrease of QOL compared with the carboplatin group in the AUC of psychological and two global scales, in the Dif max of psychological and linear analogue global scales.These results suggested that this questionnaire reflects differences in the influence of chemotherapy, and that AUC and Dif max may be useful indices for the analysis of QOL as measures to assess multidimensional QOL.
Malignant fibrous histiocytoma of the trachea
Authors: Vinod Shalini K , Macleod Craig A , Barnes David J , Fletcher Julie 
Published: March 2003

AbstractPrimary tracheal sarcomas are rare. Only 23 cases have previously been reported in the English literature. The present case describes a 72‐year‐old woman with a malignant fibrous histiocytoma of the trachea. She underwent an endoscopic resection followed by radiotherapy and is well at 12 months follow up. Other cases are reviewed. Tracheal resection is the standard care. However, local resection with postoperative radiotherapy remains an option. Adjuvant chemotherapy may improve local control. Long‐term survival has been documented.
Characterization of immunoglobulin binding factor in sputum from patients with chronic airway diseases
Authors: Ichikawa Waka , Ogushi Fumitaka , Tani Kenji , Maniwa Koji , Kamada Masaharu , Ohmoto Yasukazu , Sakatani Mitsunori , Sone Saburo 
Published: March 2003

Objective:Immunoglobulin binding factor (IgBF) is known to bind immunoglobulin, to interact with anti‐Fcγ‐III antibodies and to be present in the lower respiratory tract of normal healthy subjects. In this study, in order to clarify the role of IgBF in vespiratory diseases, we investigated whether IgBF exists in the airway of patients with chronic airway diseases. Methodology: IgBF was measured in the sputum of 28 normal subjects and 59 patients with chronic airway diseases including 37 cases of chronic bronchitis, 18 bronchiectasis, and four diffuse panbronchiolitis by enzyme‐linked immunosorbent assay. Results: Immunoglobulin binding factor concentration in the sputum of patients with chronic airway diseases (purulent sputum, 50.2 ± 8.2 μg/mL; mucoid sputum, 88.6 ± 12.8 μg/mL) was higher than that in induced sputum of normal subjects (6.3 ± 5.5 μg/mL; P < 0.001). Immunoglobulin binding factor level in mucoid sputum was significantly higher than that in purulent sputum (P < 0.05). A significant inverse correlation was shown between the IgBF level and the elastase activity in sputum, and the concentration of IgBF purified from seminal plasma was decreased by treatment with neutrophil elastase, indicating that IgBF might be degraded by elastase. In the gel filtration chromatography of both types of sputum, IgBF was eluted in a region corresponding to a molecular weight of 27 kDa as a single peak. Western blot analysis with a monoclonal antibody to IgBF indicated that IgBF in both types of sputum had a molecular weight of 27 kDa under non‐reducing conditions and of 16 kDa under reducing conditions. Conclusion: These results demonstrate that a high level of IgBF is present in the respiratory tract of patients with chronic airway diseases and may be related to the pathogenesis of these diseases.
Do subjects with asthma have greater perception of acute bronchoconstriction than smokers with airflow limitation?
Authors: Massasso David H , Salome Cheryl M , King Gregory G , Seale J Paul , Woolcock Ann J 
Published: March 2003

Objective:Smokers who develop chronic airflow limitation (CAL) do not usually present for medical attention until their lung disease is well advanced. In contrast, asthmatic subjects experience acute symptoms and present for care early in the course of their disease. The aim of this study was to determine whether subjects with asthma differ from smokers with CAL in their ability to perceive acute methacholine‐induced bronchoconstriction. Methodology: Thirteen subjects with diagnosed asthma and 10 current smokers with CAL, defined as forced expiratory volume in 1 s (FEV1) < 75% predicted and FEV1/forced vital capacity < 80%, with no previous diagnosis of asthma, were challenged with methacholine. Symptom severity was recorded on a Borg scale. Lung volumes were measured before challenge and after the FEV1 had fallen by 20%. Results: After methacholine falls in FEV1 were similar in the asthmatic subjects and smokers. The regression lines relating change in FEV1 to symptom score were significantly steeper in asthmatic subjects than smokers (0.13 ± 0.04, 0.03 ± 0.04, respectively, P < 0.01). At 20% fall in FEV1 there were no significant differences between asthmatic subjects and smokers in the magnitude of change of lung volumes. Conclusions: In asthmatic subjects, symptoms are closely related to change in FEV1. In smokers with CAL, symptoms change little during bronchial challenge despite large changes in FEV1. The differences in perception between the two subject groups are not due to differences in acute hyperinflation during challenge. We propose that heavy smokers may adapt to poor lung function, or may have damaged sensory nerves as a result of prolonged cigarette smoking.
Increased circulating CD16+ CD14dim monocytes in a patient with pulmonary alveolar proteinosis
Authors: YOSHIOKA Yasuko , OHWADA Akihiko , HARADA Norihiro , SATOH Naotake , SAKURABA Shoko , DAMBARA Takashi , FUKUCHI Yoshinosuke 
Published: March 2003

Abstract:Pulmonary alveolar proteinosis (PAP) is characterized by filling of the alveoli with a periodic acid‐Schiff‐positive proteinaceous material. Although the pathogenesis of primary or idiopathic PAP remains unknown, it has been proposed that a deficiency or loss of responsiveness of the monocyte/macrophage lineage to granulocyte–macrophage colony stimulating factor (GM‐CSF) is involved in PAP. Secondary PAP is associated with haematological malignancies, especially in myeloid disorders. Herein, we report on an adult with PAP associated with myelodysplastic syndrome (MDS). The CD16+ CD14dim monocytes comprise 5–10% of circulating monocytes in healthy volunteers. Flow cytometric analysis of the patient in the present study revealed increased CD16+ CD14dim monocytes in the peripheral blood. It has been demonstrated that the expression of CD16 and CD14 is regulated by macrophage colony stimulating factor (M‐CSF) and GM‐CSF. Hence, serum cytokines were analysed in our patient and the concentration of serum GM‐CSF was found to be less than the lower limit of the assay. In addition, serum M‐CSF and granulocyte colony stimulating factor levels were only slightly increased above the normal range. These results suggest that the increase in the CD16+ CD14dim subpopulation in the circulation of our patient indicates another pathogenetic mechanism for secondary PAP, such as hyperresponsiveness of the monocyte/ macrophage lineage to these cytokines.
Effects of heart rate and right ventricular pressure on right coronary arterial flow and its systolic versus diastolic distribution in a variety of congenital heart diseases in children
Authors: Watanabe Naoyuki , Awa Shoichi , Akagi Michio , Ando Yasushi , Oki Naoki , Waragai Tadashi , Hosaki Akira , Kawamata Hikari , Kamisaka Keiko 
Published: March 2003

Abstract Background and Methods: In order to elucidate the underlying adjusting mechanism of human right coronary arterial (RCA) flow to increased right ventricular pressure (RVP) in children, we recorded RCA flow velocity in 24 pediatric cardiac patients at the orifice of its main trunk at the time of heart catheterization using the Doppler guidewire.
Results
: The ratio of diastolic flow (DF)/total flow (TF), or the proportion of the DF time integral over a total of one cardiac cycle, had a negative correlation with heart rate (HR; r=–0.58, n=11) in children with normal right ventricular systolic pressure (RVSP; RVSP <35 mmHg). In contrast, the DF/TF ratio had a good correlation (r=0.88, n=24) with RVSP in all patients under study. The ratio of diastolic area (DA)/total area (TA), defined as the ratio of an area encircled by the aortic pressure curve above and the RVP curve below for diastole, over a total of one cardiac cycle, representing the overall effect of both HR and transcoronary pressure difference, also correlated well (r=0.89, n=24) with DF/TF. Total volume flow of the RCA also increased (r=0.76, n=24) with increases in RVSP, first by an increase in flow velocity through the RCA, during both systole and diastole, then by widening of the RCA lumen at very high pressures. These changes were initially more dependent on diastole with increasing RVSP because: (i) of a more marked augmentation of flow velocity in diastole compared with systole; and then (ii) of a significant decrease in flow velocity in systole at very high pressures.
Conclusions
: We clarify how the RCA manages to increase flow through it at different HR as a function of chronic RVP overload in pediatric cardiac patients.
Contact pressure distribution in the supine position in low‐birth weight infants analyzed by a photoelastic method
Authors: Fujimatsu Mariko , Fujita Takehisa , Hashimoto Kiyoshi , Nakagawa Hirofumi 
Published: March 2003

Background
: Contact pressure distribution patterns in the supine position in low‐birth weight (LBW) neonates were analyzed by the use of a photoelastic method.
Methods
: A total of 61 subjects (LBW neonates, mature (bodyweight >2500 g at birth) neonates, normal infants and Down syndrome (DS) infants) were selected for the study. Infants were placed on a photoelastic measuring table. Photoelastic images generated in the contact regions of the body were photographed with a camera and printed on monochrome paper. The coefficient of variation in the pressure distribution value (Pcv) and the top and bottom ratio (μ) of the trunk at the center of pressure were calculated.
Results
: The Pcv value was significantly lower in DS than LBW (P<0.001), mature (P<0.002) and normal infants (P<0.01). The μ value in LBW and mature neonates was 48.9 and 50.2%, respectively. Normal infants had a μ value of 44.0%, which was significantly lower than that in LBW neonates. However, there was no significant difference between LBW and DS infants.
Conclusions
: Neurological impairment specifically affects the data obtained by photoelastic analysis.
Epidemiology of Helicobacter pylori infection in children: A serologic study of the Kyushu region in Japan
Authors: Yamashita Yasuhiro , Fujisawa Takuji , Kimura Akihiko , Kato Hirohisa 
Published: March 2003

Background
: The prevalence of Helicobacter pylori infection in children varies as a function of socioeconomic development, with low rates in developed countries and high rates in developing countries. The prevalence of H. pylori infection in Japanese children is unknown.
Methods
: The present study examined the effect of living conditions on the prevalence of H. pylori infection in children. We determined the prevalence of H. pylori infection in healthy children of the Kyushu region in Japan and compared it with the prevalence in institutionalized children with severe neurologic illness. Serum concentrations of anti‐H. pylori IgG antibody were measured by an enzyme‐linked immunosorbent assay in 336 healthy children and 56 patients with severe neurologic impairment. An antibody concentration >50 units/mL was taken as evidence of infection.
Results
: The prevalence of H. pylori seropositivity in healthy children increased with age (P<0.0001) and was 29% in children 15–19 years of age. This value is slightly higher than prevalences reported in developed countries (5–15%), but is lower than in developing countries (30–60%). Seropositivity did not vary with respect to gender, water supply or location of housing. Helicobacter pylori seropositivity was more prevalent among institutionalized children aged 5–19 years than their healthy counterparts (P<0.005).
Conclusions
: The intermediate prevalence of H. pylori seropositivity in healthy children between that measured in developed and developing countries is consistent with the socioeconomic ‘westernization’ of Japan.
Early intervention for infants with autistic spectrum disorders in Japan
Authors: Kobayashi Ryuji , Takenoshita Yuka , Kobayashi Hiromi , Kamijo Atsushi , Funaba Kunimi , Takarabe Morihisa 
Published: March 2003

Abstract

Background
: To date, many researchers in Japan have assumed that the cause of autistic spectrum disorders is attributable to some disorder in the ability of the child. However, we have been working on the premise that autistic spectrum disorders are brought about by relationship disturbances in early infancy and have been attempting to validate this hypothesis through early intervention.
Methods
: We have examined the developmental process of affective communication in infants with autistic spectrum disorders. We have postulated that approach–avoidance motivational conflict (Richer) is the primary factor impeding the development of affective communication and have focused therapeutic intervention on this perspective.
Results
: As a result, attachment behavior was markedly improved in children, but affective communication with their mothers was not. Examing the mothers’ images of themselves in infancy in mother–infant psychotherapy, problems that the mothers had themselves in infacy with attachment behavior to their own mothers affected the mothers’ internal representation of their children, leading to active evolution of mother–child interaction and development of affective communication between the mother and child.
Conclusions
: In this context, the basis and significance of the internal representation of both parties being determinants in the quality of mother–child communication are discussed. Our goal in early intervention is not the elevation of a child’s linguistic–cognitive abilities, but the creation of a comforting relationship in which both parent and child can live securely, without strain.