bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alloy/Perovskite Compounds Modified by Plasma Treatment and their Role in Enhancing the Capacitance of Sustainable Graphene Supercapacitors
Authors: Mendoza Ricardo , Floriano‐Limón Claudia , Esquivel‐Castro Tzipatly , Mtz‐Enriquez Arturo , Padmadas Padmasree , Perez‐Mayen Leonardo , Flores‐Zúñiga Horacio , Oliva Jorge 
Published: January 2024

AbstractGraphene electrodes were firstly printed on recycled single‐use‐packets. Later, the Ni50Mn35In15 (NMI) alloy or Ca2.9Nd0.1Co3.9Cu0.1O9, (CNCCO) misfit perovskite was deposited on the graphene electrodes to enhance their capacitive performance. Next, flexible supercapacitors (SCs) were assembled by using such electrodes. The SCs made with NMI and CNCCO powders were named as GNMI‐SC, and GCNCCO‐SC, respectively. Those ones produced capacitances/energy‐densities of 761.8 F g−1/152.6 Wh kg−1 and 207.7 F g−1/41.6 Wh kg−1, respectively. Subsequently, a mixture 1 : 1 of NMI and CNCCO powders was melted/coalesced at 1700 °C by using a plasma treatment in argon atmosphere and obtained in this way a NMI/CNCCO composite powder. The SC made with this last composite generated a capacitance/energy‐density of 1235.2 F g−1/247.3 Wh kg−1. Those last values are 62–500 % higher than these for the GNMI‐SC, and GCNCCO‐SC devices. Other benefits obtained after the introduction of the NMI/CNCCO powders into the SCs were: 1) the formation of additional Cu2+, Mn4+, Nd2+ and In3+ species, which enhanced the capacitance; 2) the capacitance retention was maintained above 93 % after 500 cycles of charge discharge; and 3) the lowest values of series and charge transfer resistances were obtained, which favored the ion diffusion/storage in the SC electrodes.
Procedure Optimization for Green Synthesis of Magnetic‐Copper Nanoparticles by Aqueous Alcea Medicinal Plant Extract and Their Photocatalytic Properties
Authors: Abdirad Niloufar , Kamran‐Pirzaman Arash 
Published: January 2024

AbstractIn this research, the biosynthesis method was used for Fe3O4/CuO core‐shell nanocomposite using by aqueous Alcea medicinal plant extract, which aimed to synthesize antibacterial substances against common resistant bacteria. Antibacterial effects of various samples synthesized in different concentrations were evaluated against gram‐positive and negative bacteria in Mueller Hilton agar culture medium. The photocatalytic properties were carried out in a period of 140 minutes, and the maximum effect of the sample was 76 % in 100 minutes. FTIR, SEM, EDX and XRD tests confirmed the correct to design the experiment. synthesis of the nanocomposite with an average size of 38 nm and a surface charge of 23.1 mV. To obtain the best and most effective conditions for the synthesis of antibacterial nanoparticles, the CCD method was used. The main purpose of this research work is to use a medicinal plant as a reducer in the synthesis of metal composite nanoparticles, which plant itself has healing and antimicrobial properties in traditional medical science.
Long‐Range Uniform Deposition of Ag Nanoseed on Cu Current Collector for High‐Performance Lithium Metal Batteries
Authors: Kim Ju Ye , Chae Oh B. , Kim Gukbo , Peterson Andrew A. , Wu Mihye , Jung Hee‐Tae 
Published: January 2024

AbstractUniform lithium deposition is essential to hinder dendritic growth. Achieving this demands even seed material distribution across the electrode, posing challenges in correlating the electrode's surface structure with the uniformity of seed material distribution. In this study, the effect of periodic surface and facet orientation on seed distribution is investigated using a model system consisting of a wrinkled copper (Cu)/graphene structure with a [100] facet orientation. A new methodology is developed for uniformly distributed silver (Ag) nanoparticles over a large area by controlling the surface features of Cu substrates. The regularly arranged Ag nanoparticles, with a diameter of 26.4 nm, are fabricated by controlling the Cu surface condition as [100]‐oriented wrinkled Cu. The wrinkled Cu guides a deposition site for spherical Ag nanoparticles, the [100] facet determines the Ag morphology, and the presence of graphene leads to spacings of Ag seeds. This patterned surface and high lithiophilicity, with homogeneously distributed Ag nanoparticles, lead to uniform Li+ flux and reduced nucleation energy barrier, resulting in excellent battery performance. The electrochemical measurements exhibit improved cyclic stability over 260 cycles at 0.5 mA cm−2 and 100 cycles at 1.0 mA cm−2 and enhanced kinetics even under a high current density of 5.0 mA cm−2.
High‐Performance 3D Stacked Micro All‐Solid‐State Thin‐Film Lithium‐Ion Batteries Based on the Stress‐Compensation Effect
Authors: Wu Xinru , Wang Lihao , Gu Wenqin , Wang Jian , Zhuang Yonghe , Sun Hanzi , Liu Junfu , Wang Chao , Shi Nian , Huang Xiaodong 
Published: January 2024

AbstractA novel all‐solid‐state thin‐film lithium‐ion battery (LIB) is presented to address the trade‐off issue between the specific capacity and stabilities in a conventional LIB. Different from the conventional one, this LIB device consists of two same LIB components located at the front and back surfaces of the substrate, respectively. These two LIB components form parallel connection by using the conductive through vias distributed in the substrate. Compared with the conventional one, this LIB device doubles the areal specific capacity. More importantly, due to the stress‐compensation effect, this device effectively suppresses the stress induced by its volume changes resulting from the lithiation/delithiation processes and thermal expansion. Consequently, this device shows good cycling and thermal stabilities even when working at an industrial‐grade high temperature of 125 °C. To further improve the specific capacity without sacrificing the stabilities, a 3D stacked LIB is successfully realized by using this LIB device as the cell, in which each cell is parallelly connected by using the above‐mentioned conductive through vias. This 3D stacked LIB is experimentally demonstrated to obtain high specific capacity (79.9 µAh cm−2) and good stabilities (69.3% of retained capacity after 100 cycles at 125 °C) simultaneously.
Nanohybrids of BCN‐Fe1−xS for Sodium and Lithium Hybrid Ion Capacitors
Authors: Bahadur Rohan , Jason J Ian , Sakamoto Yasuhiro , Chang Shery , Yu Xiaojiang , Breese Mark BH , Bhargava Suresh K. , Lee Jang Mee , Panigrahi Puspamitra , Vinu Ajayan 
Published: January 2024

AbstractHybrid ion capacitors (HIC) are receiving a lot of attention due to their potential to achieve high energy and power densities, but they remain insufficient. It is imperative to explore outstanding and environmentally benign electrode materials to achieve high‐performing HIC systems. Here, a unique boron carbon nitride (BCN)‐based HIC system that comprises a microporous BCN structure and Fe1−xS nanoparticle incorporated BCN nanosheets (BNF) as cathode and anode, respectively is reported. The BNF is prepared through a facile one‐pot calcination process using dithiooxamide (DTO), boric acid, and iron source. In situ, crystal growth of Fe1−xS facilitates the formation of BCN structure through the creation of holes/defects in the polymeric structure. The first principle density functional (DFT) theory simulations demonstrate the structural and electronic properties of the hybrid of BCN and Fe1−xS as compelling anode materials for HIC applications. The DFT calculations reveal that both BCN and BNF structures have excellent metallic characters with Li+ storage capacities of 128.4 and 1021.38 mAh g−1 respectively. These findings are confirmed experimentally where the BCN‐based HIC system delivers exceptional energy and power densities of 267.5 Wh kg−1/749.5 W kg−1 toward Li+ storage, which outweighs previous HIC performances and demonstrates favorable performance for Li+ and Na+ storages.
Stress degradation study of Etoricoxib, isolation, and characterization of major degradation impurity by preparative high‐performance liquid chromatography, liquid chromatography‐mass spectrometry, and nuclear magnetic resonance: Validation of ultra‐performance liquid chromatography method
Authors: Goguladinne Babu Reddy , Shyamala Pulipaka , Rao K. M. V. Narayana 
Published: January 2024

AbstractEtoricoxib (ETO) is a selective cyclooxygenase‐2 inhibitor, used as a nonsteroidal anti‐inflammatory drug. In this study, a detailed investigation was conducted on the degradation behavior of ETO under acidic, basic, neutral, photolytic, oxidative, and thermal degradation conditions as per the International Conference on Harmonization (ICH) guideline Q1A (R2). A gradient “ultra‐performance liquid chromatography (UPLC)” method was developed for separating the degradation products formed under various degradation conditions along with process‐related impurities. Acquity BEH phenyl column was used for the separation of analytes and 0.1% formic acid in water and 0.05% formic acid in acetonitrile:methanol (8:2 %v/v) were used as mobile phase‐A and mobile phase‐B. A major degradant namely, N‐oxide impurity was observed in oxidative degradation along with two minor degradants where N‐oxide was confirmed based on LC‐mass spectrometry (LC‐MS) studies. Further, the major degradant was enriched and isolated using preparative HPLC and the conformation of the N‐oxide impurity was established using nuclear magnetic resonance techniques including two‐dimensional studies and high‐resolution MS. In addition, the method for related substances by UPLC has been validated by considering a major degradant, namely N‐oxide along with process‐related impurities as per the ICH guidelines validation parameters.
Semilicoisoflavone B induces oral cancer cell apoptosis by targeting claspin and ATR‐Chk1 signaling pathways
Authors: Hsieh Ming‐Ju , Lin Chia‐Chieh , Lo Yu‐Sheng , Chuang Yi‐Ching , Ho Hsin‐Yu , Chen Mu‐Kuan 
Published: January 2024

AbstractThe prevalence of oral squamous cell carcinoma (OSCC) is increasing worldwide mainly due to poor oral hygiene and unrestricted lifestyle. Advanced‐stage OSCC is associated with poor prognosis and a 5‐year survival rate of only 30%–50%. The present study was designed to investigate the anticancer effect and mode of action of Glycyrrhiza‐derived semilicoisoflavone B (SFB) in 5‐fluorourasil (5FU)‐resistant human OSCC cell lines. The study findings revealed that SFB significantly reduces OSCC cell viability and colony formation ability by arresting cell cycle at the G2/M and S phases and reducing the expressions of key cell cycle regulators including cyclin A, cyclin B, CDC2, and CDK2. The compound caused a significant induction in the percentage of nuclear condensation and apoptotic cells in OSCC. Regarding pro‐apoptotic mode of action, SFB was found to increase Fas‐associated death domain and death receptor 5 expressions and reduce decoy receptor 2 expression, indicating involvement of extrinsic pathway. Moreover, SFB was found to increase pro‐apoptotic Bim expression and reduce anti‐apoptotic Bcl‐2 and Bcl‐xL expressions, indicating involvement of intrinsic pathway. Moreover, SFB‐mediated induction in cleaved caspases 3, 8, and 9 and cleaved poly(ADP‐ribose) polymerase confirmed the induction of caspase‐mediated apoptotic pathways. Regarding upstream signaling pathway, SFB was found to reduce extracellular signal regulated kinase 1/2 (ERK) phosphorylation to execute its pro‐apoptotic activity. The Human Apoptotic Array findings revealed that SFB suppresses claspin expression, which in turn caused reduced phosphorylation of ATR, checkpoint kinase 1 (Chk1), Wee1, and CDC25C, indicating disruption of ATR‐Chk1 signaling pathway by SFB. Taken together, these findings indicate that SFB acts as a potent anticancer compound against 5FU‐resistant OSCC by modulating mitogen‐activated protein kinase (MAPK) and ATR‐Chk1 signaling pathways.
Ropivacaine combined with sorafenib attenuates hepatocellular carcinoma cell proliferation and metastasis by inhibiting the miR‐224/HOXD10 axis
Authors: Wang Wenting , Wang Tao , Lin Hongyun , Liu Desheng , Yu Peng , Zhang Jing 
Published: January 2024

AbstractObjectiveThe development of drug resistance in hepatocellular carcinoma (HCC) cells limits the effectiveness of sorafenib (Sor). However, the regulatory mechanisms underlying the effects of the combination Sor and ropivacaine (Rop) on HCC cells remain unclear.MethodsmiR‐224 and HOXD10 mRNA expression in HCC cells was analyzed using qRT‐PCR. CCK‐8, Transwell assays and tumor formation experiments in nude mice were used to assess HCC cell proliferation, migration, and invasion. Migration of HCC cells was also analyzed using a cell scratch assay. Hematoxylin and eosin staining was used to detect tumor area.ResultsmiR‐224 expression profoundly increased in HepG2 and Huh7 cells. Treatment with Rop and/or Sor blocked miR‐244 expression, especially the combination treatment. Transfection of miR‐224 mimic increased HCC cell proliferation and tumor size in nude mice, and migration and invasion in vitro in the presence of Rop and Sor compared to the negative control mimic. Dual‐luciferase reporter assays showed that HOXD10 was targeted by miR‐224. HOXD10 protein expression and was markedly reduced in HepG2 and Huh7 cells. Rop and/or Sor treatment increased HOXD10 protein expression, particularly the combination treatment. miR‐224 negatively regulated HOXD10 expression in HCC cells treated with Rop and Sor. Transfection‐mediated silencing of HOXD10 increased HCC cell proliferation, migration, and invasion in the presence of Rop and Sor compared with negative control transfection.ConclusionThe combination of Rop and Sor attenuates HCC cell proliferation and metastasis via the miR‐224/HOXD10 axis.
Extremely high peritoneal cancer index in colorectal peritoneal metastases demonstrates safety and overall survival benefit in selected patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy
Authors: Ben‐Yaacov Almog , Levine Olivia , Schtrechman Gal , Adileh Mohammad , Beller Tamar , Boursi Ben , Halpern Naama , Goldstein Adam , Ben‐Yakov Gil , Nissan Aviram , Laks Shachar 
Published: January 2024

AbstractBackgroundColorectal peritoneal metastases are a devastating consequence of colorectal cancer (CRC) with extremely poor prognosis. Patients that can undergo complete cytoreduction by cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) have a markedly improved overall survival. Traditionally, patients with extremely high peritoneal cancer index (PCI), PCI >20, are not offered CRS/HIPEC.MethodsWe performed a retrospective analysis of our prospectively maintained CRS/HIPEC database and evaluated all patients with CRC peritoneal metastases between 2012 and 2022. We divided the cohorts between those with low operative PCI (PCI<20) and high operative PCI (PCI =>20). We examined demographic, clinicopathologic data, perioperative, and oncological outcomes between the cohorts.ResultsOf the 691 patients who underwent CRS/HIPEC, 289 were evaluable with CRC metastases, 234 with PCI <20 and 43 with PCI => 20. Median radiologic preoperative and operative PCI was 4 and 10 versus 7 and 24.5 in the low and high PCI cohorts, respectively. Operative time was longer (6 vs. 4 h) and blood loss higher (500 vs. 400 mL) in the high PCI cohort. All other demographic, clinicopathological, and operative characteristics were similar. Median disease free survival (DFS) was longer in the low PCI cohort (11.5 vs. 7 months) but overall survival (OS) showed benefit (41.3 vs. 31.8 months), (p = 0.001 and p = 0.189, respectively), comparatively with an only chemotherapy strategy.ConclusionsAppropriately selected patients with CRC metastases and extremely high PCI demonstrate similar perioperative safety outcomes in experienced tertiary referral centers. Despite a shorter median DFS, these carefully selected patients demonstrated similar median OS.
Human Resource Management for Military Organizations: Challenges and Trends
Authors: op den Buijs Tessa , Olsthoorn Peter 
Published: January 2024

AbstractIn this chapter, we examine the challenges military organizations face today in terms of their HRM policies and the effect of the institutional environment and strategy on these policies. We begin with an overview of the evolution of HRM over time, and how it is understood today, and will outline some general theories within the HRM domain. Today’s changes in, for example, the internal and external environment of military organizations pose important challenges for the military’s personnel policies and organizational fit. We will discuss the reactions by military organizations to these challenges. What trends do the challenges lead to in relation to the professionalization of the armed forces? Next, we elaborate on some of the more pressing challenges, such as motivating young people, the development in the field of talent management in relation to the organizational strategy, recent technological developments, labor market developments such as diversity in the workforce, but also private military companies, and of course the global security situation. We end this chapter with a short conclusion.
Innovation and Policy in Cancer Pain Management: Systemic Interactions in Tanzania
Authors: Daniels Chux , Steenmans Ine , Makene Fortunata Songora , Ngilangwa Richard , Ngoma Twalib , Santos Cristina , Mackintosh Maureen 
Published: January 2024

Abstract﻿In contrast to India, Tanzania imports all its opiate medication, yet there too, need is unmet. This chapter reports findings from a sustained collaborative effort in Tanzania to understand the roots of undertreatment of severe cancer pain. It analyses the complex sources of this cancer care failure, contrasting the Tanzanian situation to the Ugandan experience of providing more widespread access to opiate medication for severe pain. The chapter describes findings from multi-sectoral and multi-disciplinary workshops in Tanzania, documenting critical causal feedback loops that generate sustained undertreatment of severe pain, and identifies innovations that could turn this outcome around.
Identification and validation of the association of Janus kinase 2 mutations with the response to immune checkpoint inhibitor therapy
Authors: Chen Peipei , Long Junyu , Zhang Jiayang , Xie Fucun , Wu Wei , Tian Zhuang , Zhang Shuyang , Yu Kang 
Published: January 2024

Abstract
Background
Janus kinase 2 (JAK2) mutation plays an important role in T cell immunity. However, the effect of JAK2 mutation on immunotherapy is largely uncharacterized.

Methods
In this study, we analyzed the effect of JAK2 mutation on the efficacy and outcomes of immune checkpoint inhibitor (ICI) therapy in the discovery cohort (n = 662) and the verification cohort (n = 1423). Furthermore, we explored the association of JAK2 mutation with the tumor immune microenvironment in a multiomics cohort.

Results
In the discovery cohort (n = 662), JAK2 mutant-type patients had a better objective response rate (58.8% vs. 26.7%, P = 0.010), durable clinical benefit (64.7% vs. 38.9%, P = 0.043), progression-free survival (hazard ratio [HR] = 0.431, P = 0.015), and overall survival (HR = 0.378, P = 0.025), relative to JAK2 wild-type patients. Moreover, we further verified the prognostic significance of JAK2 mutation in an independent ICI treatment cohort with a larger sample size (n = 1423). In addition, we discovered that the JAK2 mutation was remarkably related to increased immunogenicity, such as a higher TMB, higher expression of costimulatory molecules and stimulation of antigen processing mechanisms. In addition, JAK2 mutation was positively correlated with activated anticancer immunity, such as infiltration of various immune cells and higher expression of chemokines.

Conclusion
Our study demonstrates that JAK2 mutation is a novel marker that can be used to effectively predict prognosis and response to ICI therapy.
Analysis of Karst Surface Anisotropy Using Directional Semivariograms, Slovenia
Authors: Verbovšek Timotej 
Published: January 2024

AbstractThe paper presents a study of the anisotropic properties of the karst surface through the use of semivariograms. Karst is formed by hydrogeological and tectonic deformations that determine the surface and subsurface characteristics of the area. Among the most prominent surface features are dolines, which generally form in a linear direction. Semivariograms can be used to determine both the preferred direction of anisotropy and the degree of anisotropy. The surface exhibits the greatest elevation variability in the direction of the most diverse terrain, corresponding to dolines. The results, based on the eight karst areas studied, show that it is possible to detect and, more importantly, quantify anisotropy in all karst areas, although in some cases it is impossible or difficult to detect visually. The directions of the semivariograms agree very well with those obtained from the visual inspection of the maps, as well as with the orientations of the main faults. The method is therefore very useful for quantitative determination of anisotropy and its interpretation could be greatly improved by using the detailed structural geological maps of the karst.
Neues Zulassungsverfahren Humanmedizin: höhere individuelle Gerechtigkeit, aber Verstärkung des Landarztmangels?
Authors: Müller-Hilke Brigitte , Finger Claudia , Hampe Wolfgang 
Published: January 2024

Zusammenfassung
Hintergrund
Das Bundesverfassungsgericht hat 2017 die Wartezeitquote und die Beschränkung der Ortspräferenzen bei der Vergabe der Studienplätze in der Humanmedizin als verfassungswidrig erklärt und einen Bundeslandausgleich für Abiturnoten gefordert. Daraufhin wurde ab 2020 die Wartezeitquote durch die „Zusätzliche Eignungsquote“ ersetzt, die Zahl der Ortspräferenzen nicht mehr begrenzt und ein Abiturnotenausgleich eingeführt. Die vorliegende Studie untersucht, welche Auswirkungen diese Umstellung auf die neuen Erstsemester hat.

Methoden
Daten der Stiftung für Hochschulzulassung wurden für die letzten beiden Wintersemester (WS) vor und die ersten 3 WS nach der Umstellung verglichen.

Ergebnisse und Diskussion
Während sich der Einfluss des neuen Verfahrens auf die Studierenden mit vorheriger medizinnaher Ausbildung noch nicht endgültig beurteilen lässt, bleiben durchschnittliche Abiturnote und Frauenanteile annähernd unverändert und der Studienort ist nach wie vor bevorzugt wohnortsnah. Die Studierenden sind jünger geworden und der Länderausgleich gleicht die Chancen für Abiturient:innen aus Bundesländern mit besseren und schlechteren Abiturnoten an. Ein neues Ungleichgewicht entsteht jedoch, weil der Länderausgleich die Anzahl der Bewerber:innen berücksichtigt – und ländlich geprägte Bundesländer weniger Bewerber:innen hervorbringen. Da aber Landärzt:innen häufig auch ursprünglich aus ländlichen Gebieten stammen, ist eine Verschärfung des Ärzt:innenmangels gerade in den neuen Bundesländern ein mögliches Zukunftsszenario. Ein veränderter Notenausgleichsmechanismus könnte hier zusätzlich zur Landarztquote entgegenwirken.
School starting age and the impact on school admission
Authors: Cáceres-Delpiano Julio , Giolito Eugenio 
Published: January 2024

AbstractThis study employs Chilean administrative data to investigate the impact of school starting age on the characteristics of students’ initial enrolled schools. Employing minimum age requirements and an RD design to mitigate endogeneity concerns, we identify benefits linked to commencing school at a later age. Our findings demonstrate that children starting school at an older age enroll in institutions with higher average scores in standardized tests and interact with older peers whose parents have higher education levels. Furthermore, they display a heightened likelihood of entering schools employing academic selection methods, a greater proportion of full-time teachers, and a larger percentage of instructors with a 4-year college degree. The analysis by level of education of the parents and gender reveals that most of our results are driven by parents with lower levels of education and girls. Subgroup analyses further reveal that many of our results are driven by parents with lower levels of education and parents of girls.