bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation of the readiness of future officers to perform assigned tasks with an emphasis on the use of highly functional complexes of physical exercises
Authors: Bondarovitch Oleg , Bogdanov Mihail 
Published: January 2024

Today, improving the system of professional training of future officers of institutions of the security and defense sector of Ukraine is a priority task. The development of modern methods, organizational and pedagogical conditions, the construction of effective and highly functional pedagogical models contributes to the intensification of the training of officer personnel, which will ensure in the future the effective, high-quality and reliable performance of assigned tasks by them and subordinate personnel.
Research methods: idealization, formalization, axiomatic, historical and logical, descent from concrete. In the process of research and experimental work, the experience of combat operations was used, as well as the experience of organizing the system of physical and special physical training of servicemen of institutions of the security and defense sector of Ukraine. The main tasks of scientific research: to conduct an analysis of scientific-methodical and special literature in the direction of forming the readiness of future officers for professional activity; to conduct an analysis of special and reference literature in the direction of organizing the system of physical and special physical training of representatives of the studied category.
As a result of a theoretical study, the members of the scientific research group developed organizational and pedagogical conditions for the formation of the readiness of future officers of the institutions of the security and defense sector of Ukraine to perform assigned tasks with an emphasis on the use of highly functional complexes of physical exercises (in the system of special physical training).
Pathological evaluation of the effects of the drug clozalbent f on tissues and cytostructure of the trematode <i>Fasciola gigantica</i> (Cobbold, 1855)
Authors: Bittirov A. M. , Gazaeva A. A. , Bittirov I. A. , Bittirov R. B. 
Published: January 2024

The aim of the study was a pathomorphological evaluation of the effect of the new drug Clozalbent F (Clozalbent F) on populations of the trematode Fasciola gigantica (Cobbold, 1855) with monoinvasion of fasciolеsis in cows. In the experiment, on days 7-10 after a single oral application to cows spontaneously infected with trematodes Fasciola gigantica, the effects of the drug Clozalbent F (Clozalbent F) at a dose of 1.25 g/10 kg of live weight appear in the form of irreversible pathomorphological changes in organs and tissues marit and premarital. In the body of trematodes, carbohydrate, protein, water and salt metabolism is disturbed, toxins are formed, and hydropic dystrophy of tissues increases with large amounts of water in them. Hydration of F. gigantica cells and tissues causes them to swell, then decay and necrosis. Under the influence of Closalbent F, vacuoles are formed in the tegument of trematodes in the intercellular spaces filled with turbid moisture. The drug enters the body of F. gigantica through the neo-dermis, causing irreversible path changes (destruction, disorganisation, decomposition, autolysis, protein, carbohydrate, hydropic dystrophy, necrobiosis and necrosis) of cells and tissues in mature trematodes. On the 7-10th day of the experiment, after the action of the Clozalbent F at a dose of 1,25 g/10 kg of live weight, F. gigantica marita showed complete disintegration of tegument, suckers and genitalia cells, which was confirmed by histological methods (TS, BFS, SA, CHIC) and testifying to its high efficiency and biosafety fasciolеsis in cow.
Perlindungan Hukum Terhadap Perempuan dari Kekerasan Seksual
Authors: Nova Efren , Edita Elda  
Published: January 2024

Perlindungan hukum terhadap perempuan dari tindak pidana kekerasan dan bebas dari penyiksaan atau perlakuan yang merendahkan martabat manusia merupakan hak semua warga negara yang merupakan hak kontitusional yang dijamin dalam Undang-Undang Dasar 1945. Kekerasan seksual adalah isu penting dan rumit dari seluruh peta kekerasan terhadap perempuan karena adanya dimensi yang sangat khas dari perempuan, ketimpangan relasi kuasa antara pelaku dan korban adalah akar kekerasan seksual terhadap perempuan Dalam kurun waktu 5 tahun terakhir ini (2017-2022) berdasarkan data dari Sistim Informasi Online Perlindungan Perempuan dan Anak (SIMFONI PPPA) Kementerian PPPA terungkap bahwa sepanjang tahun 2022 terjadi sejumlah 25.050 kasus kekerasan terhadap perempuan yang menjadi korban kekerasan di Indonesia. Sedangkan di Sumatera Barat pada tahun 2020 sebanyak 94 kasus, tahun 2021 ada sebanyak 104 kasus dan tahun 2022 sebanyak 300 kasus. Dengan diundangkan Undang-Undang Nomor 12 Tahun 2022 tentang Tindak Pidana Kekerasan Seksual ini merupakan upaya pembaharuan hukum serta mengatasi permasalahan dalam perlindungan hukum terhadap perempuan dari Tindak Kekerasan Seksual yaitu sebagai beriku: mencegah segala bentuk kekerasan seksual, menangani, melindungi, dan memulihkan korban, melaksanakan penegakan hukum dan merehabilitasi pelaku, mewujudkan lingkungan tanpa kekerasaan seksual, dan menjamin ketidak berulangan kekerasan seksual. Hasil Penelitian menunjukan kebijakan yang telah dilakukan Pemerintah Daerah (DP3AP2KB) Propinsi Sumatera Barat dalam rangka perlindungan hukum terhadap perempuan pasca keluarnya UUTPKS adalah pembentukan Unit Pelaksana Teknis Perlindungan Perempuan dan Anak (UPTD PPA) yang merupakan amanah dari UU TPKS, di Sumatera Barat baru terbentuk di 7 (tujuh) Kabupaten /Kota, 3 ( tiga) masih dalam proses akademis dan 7 (tujuh) masih belum terbentuk sama sekali, mengadakan sosialisasi UUTPKS dan aparat penegak hukum di Sumatera Barat belum mengimplementasikan UUTPKS dalam rangka perlindungan hukum terhadap perempuan dalam kasus kekerasan seksual dengan alasan ragu karena belum adanya aturan pelaksanaan dan tetap memakai aturan yang ada.
The Ratio of Plasma Amyloid-β 1-42 over Serum Albumin Can Be a Novel Biomarker Signature for Diagnosing End-Stage Renal Disease-Associated Cognitive Impairment
Authors: Hou Yi-Chou , Chueh Ti-I , Lu Kuo-Cheng , Liu Yi-Chien , Chen Tso-Hsiao , Liu Shing-Hwa , Chen Ruei-Ming 
Published: January 2024

Background: Cognitive impairment (CI) is one of the major complications in chronic kidney disease patients, especially those with end-stage renal disease (ESRD). Limited biomarkers have been found that can significantly predict ESRD-associated cognitive decline. Objective: This cohort study aimed to investigate de novo biomarkers for diagnosis of the ESRD-associated CI. Methods: In this cohort study, qualified samples were divided into control (with an estimated glomerular filtration rate (eGFR) of≥60 mL/min and a Mini-Mental State Examination (MMSE) score of > 27), ESRD without CI (eGFR < 15 and MMSE > 27), and ESRD with CI (eGFR < 15 and MMSE < 27) groups. Levels of plasma amyloid-β (Aβ)1 - 42, serum indoxyl sulfate, and hematologic and biochemical parameters were measured. Results: Compared to the control group, levels of blood urea nitrogen, creatinine, and indoxyl sulfate were elevated in ESRD patients both without and with CI. Interestingly, ESRD patients with CI had the lowest levels of serum albumin. In contrast, levels of plasma Aβ1 - 42 were significantly higher in the ESRD with CI group than in the control and ESRD without CI groups. In addition, the ratio of plasma Aβ1 - 42 over serum albumin was significantly higher in the ESRD with CI group than in the control or ESRD without CI groups. Importantly, the area under the receiver operating characteristic curve (AUROC) for CI in the total population by the ratio of Aβ1 - 42 over albumin was 0.785 and significant (p < 0.05). Conclusions: This cohort study has shown that the ratio of plasma Aβ1 - 42 over serum albumin can be a de novo biomarker for the diagnosis and prognosis of ESRD-associated cognitive decline.
A Phase I, Randomized, SAD, MAD, and PK Study of Risvodetinib in Older Adults and Parkinson’s Disease
Authors: Werner Milton H. , Olanow C. Warren , McGarry Andrew , Meyer Christopher , Kruger Sydney , Klint Carl , Pellecchia Jacqueline , Walaker Shannon , Ereshefsky Larry , Blob Lawrence , Hassman Howard , Rodriguez Carlos , Samara Emil , Safirstein Beth , Ellenbogen Aaron 
Published: January 2024

Background: Pre-clinical studies suggest that c-Abl activation may play an important role in the etiology of Parkinson’s disease, making c-Abl an important target to evaluate for potential disease-modification. Objective: To assess safety, tolerability, and pharmacokinetics of the c-Abl inhibitor risvodetinib (IkT-148009) in healthy subjects and participants with Parkinson’s disease. Methods: Part 1 (single ascending dose (SAD)) and Part 2 (7-day multiple ascending dose (MAD)) studies were in healthy volunteers. Participants were randomized 3 : 1 across 9 SAD doses and 3 MAD doses of risvodetinib (IkT-148009) or placebo. Part 3 was a MAD study conducted at two doses in 14 participants with mild-to-moderate PD (MAD-PD). Primary outcome measures were safety, tolerability and pharmacokinetics. Exploratory outcomes in PD participants included clinical measures of PD state, GI function, and cerebrospinal fluid (CSF) concentration. Results: 108 patients were treated with no dropouts. The SAD tested doses ranging from 12.5 to 325 mg, while the MAD tested 25 to 200 mg and MAD-PD tested 50 to 100 mg in Parkinson’s participants. All active doses had a favorable safety profile with no clinically meaningful adverse events. Single dose pharmacokinetics were approximately linear between 12.5 mg and 200 mg for both Cmax and AUC0 - inf without distinction between healthy volunteers and participants with PD. Exposures at each dose were high relative to other drugs in the same kinase inhibitor class. Conclusions: Risvodetinib (IkT-148009) was well tolerated, had a favorable safety and pharmacology profile over 7-day dosing, did not induce serious adverse events and did not appear to induce deleterious side-effects in participants administered anti-PD medications.
Pengembangan E-Modul Flipbook Berbasis Problem Based Learning untuk Siswa SMA pada Materi Pencemaran Lingkungan
Authors: Wahyuni Ni Wayan Anggi Sri , Citrawathi Desak Made , Heny Ajeng Purnama 
Published: January 2024

Penelitian ini memiliki tujuan untuk mengetahui tingkat validitas dan kepratisan e-modul untuk pembelajaran biologi pada pokok bahasan pencemaran lingkungan di SMA Negeri 1 Bebandem. Jenis penelitian yang dilakukan adalah penelitian dan pengembangan (Research and Development) menggunakan model pengembangan 4D yang dimodifikasi terdiri dari tahap Define, Design, Development. Penelitian dilaksanakan denga menyebar lembar penilaian kepada para ahli, guru biologi dan peserta didik. Data hasil penelitian kemudian dianalisis menggunakan rumus uji validitas dan uji kepraktisan. Berdasarkan hasil analisis data dan pembahasan pada uji validitas didapat rerata persentase sebesar 90% Artinya e-modul yang dikembangkan sudah sangat valid untuk digunakan dalam proses pembelajaran. Hasil analisis data dan pembahasan pada uji praktikalitas mendapat rerata 88,14%. Artinya e-modul yang dikembangkan sudah sangat praktis untuk digunakan dalam kegiatan pembelajaran.
Kata kunci: E-modul, Pencemaran Lingkungan, Problem Based Learning, Research and Development (R&D)
Intervención fisioterapéutica para neuropatía periférica diabética en muñeca y mano
Authors: García Camacho Víctor Manuel , Naranjo Quinteros Juan Gabriel , García Yance Silvia del Carmen , Reales Chacón Lisbeth Josefina 
Published: January 2024

Introducción. La patología de la Neuropatía Periférica Diabética (DPN) es una afectación común, por consecuencia de la hiperglucemia, que causa daño en la conducción nerviosa, causando afectación de las manos y de los dedos, en déficit de funcionalidad, sensibilidad y fuerza de agarre. Objetivo Este estudio tuvo como finalidad determinar el efecto de la intervención fisioterapéutica para neuropatía periférica diabética en muñeca y mano. Metodología. Estudio cuantitativo, con un modelo analítico y con diseño longitudinal, donde participaron a 34 pacientes en la evaluación inicial, pero culminaron 17 pacientes después de la intervención, realizado en la parroquia Atahualpa perteneciente al cantón Ambato y el otro punto de encuentro en el cantón Cevallos todo perteneciente a la provincia de Tungurahua. Resultados. Mejoro significativamente en la presión de la mano con respecto a evaluación final frente a la evaluación inicial p=0,000, pero también existió mejora en la valoración de los reflejos de 17,6% antes de la intervención a 76,5% tras la intervención fisioterapéutica. Conclusión. Demostró que el programa de ejercicio brindo un efecto positivo para la funcionalidad, los reflejos en mano y dedos en personas con DPN. Área de estudio general: Salud. Área de estudio específica: Epidemiología y Salud Pública. Tipo de estudio: Artículos originales / Original articles.
Análisis comparativo de autoestima en estudiantes universitarios del cantón Riobamba
Authors: Sarmiento Benavides Alejandra Salomé , Pilco Guadalupe Gina Alexandra , Cañas Lucendo Manuel , Roque Herrera Yosbanys 
Published: January 2024

Introducción. La autoestima es un constructo que se caracteriza por la evaluación que el individuo hace de sí mismo. Objetivo. Comparar los niveles de autoestima en función del sexo de los estudiantes universitarios. Metodología. El estudio fue comparativo con diseño no experimental y de corte transversal. La población estuvo conformada por 1927 estudiantes matriculados en las carreras de la Facultad de Ciencias de la Salud de la Universidad Nacional del Chimborazo, Riobamba, Ecuador, seleccionado una muestra de 1146 participantes mediante un muestreo no probabilístico, en base a criterios. Los datos se recolectaron mediante la Escala de Autoestima de Rosenberg. Resultados. El 72,8% de los participantes correspondieron al sexo femenino y el 85,8% provenían del nivel socioeconómico medio. Entre los participantes predomina el nivel de autoestima elevada en las mujeres (43,6%); mientras que, en los hombres los niveles medio y elevado fueron similares (38,1%). Conclusión. Al comparar el estado de la autoestima entre ambos sexos, se observó diferencias estadísticamente significativas. Área de estudio general: Psicología. Área de estudio específica: Salud Mental. Tipo de estudio: Articulo original.
COVID-19 Pandemi Süreci Uzaktan Eğitim Döneminde Hemşirelik Öğrencilerinde Anksiyete ve Klinik Performans Öz-Yeterlilik Algısı İlişkisi
Authors: AKKUŞ Yeliz , BOSTANCI DAŞTAN Nihal 
Published: January 2024

Amaç: Bu çalışmanın amacı, COVID-19 pandemi süreci uzaktan eğitim döneminde hemşirelik öğrencilerinde anksiyete ve klinik performans öz-yeterlilik algısı arasındaki ilişkiyi belirlemektir.
Gereç ve Yöntemler: Bu çalışma tanımlayıcı ve kesitsel olarak yapıldı. Çalışmanın örneklemini bir üniversitede eğitim gören 453 lisans hemşirelik öğrencisi oluşturdu. Verilerin toplanmasında Klinik Performansta Öz-Yeterlik Ölçeği ve Spielberger Durumluk ve Sürekli Kaygı Ölçeği kullanıldı. Analizlerde parametrik (bağımsız örneklem t testi, tek yönlü Anova-gruplar arası farklılıklar için Tukey's HSD) ve parametrik olmayan testler (Kruskal–Wallis testi, İkiden fazla bağımsız grup karşılaştırılmasında anlamlılık bulunduğunda alt grup karşılaştırmaları için Bonferroni testi ve ikili karşılaştırma için Mann–Whitney U testi) ve değişkenler arasındaki korelasyon için Spearman korelasyon katsayısı kullanılmıştır.
Bulgular: Araştırmaya katılan öğrencilerin yaş ortalaması 21,47±1,92, %68,7’si kadın, %36,90’u 2. sınıf, %9,70’si COVID-19 tanısı aldığını, %61,60’sı COVID-19 olmaktan korktuğunu, %75,10’i COVID-19’dan korunma için yeterli önlemleri aldığını, %45,30’ü COVID-19 nedeniyle yakınını kaybettiğini belirtmiştir. Öğrencilerin Durumluk Kaygı Alt Ölçeğine göre %57,00’sinde yüksek düzeyde anksiyete olduğu, Süreklik Kaygı Alt Ölçeğine göre %71,10’inde yüksek düzeyde anksiyete olduğu, Klinik performans öz yeterlilik algısının orta düzeyde olduğu görülmüştür. Öğrencilerin durumluluk-süreklilik ve klinik performans öz-yeterlik algısı arasında negatif yönde anlamlı ilişki vardır (r= -0,245; p
İnfertil Kadınların Öz Şefkat, Bilinçli Farkındalık ve Ruhsal Sağlıkları Arasındaki İlişki
Authors: PALAZOĞLU Nursefa , KARACA Aysel 
Published: January 2024

Amaç: Bu çalışmada infertil kadınların ruhsal sağlık, bilinçli farkındalık ve öz şefkat düzeyleri arasındaki ilişkinin belirlenmesi amaçlanmıştır.
Gereç ve Yöntemler: Bu araştırma tanımlayıcı ve ilişkisel tiptedir. Araştırmanın verileri bir üniversite hastanesi infertilite polikliniğinde toplam 318 infertilite tanısı alan kadın ile yüz yüze görüşme yöntemi ile toplanmıştır. Araştırmanın uygulaması için bir üniversite hastanesinin etik kurulundan etik kurul izni ve araştırmanın yürütüldüğü üniversite hastanesi başhekimliğinden uygulama izni alınmıştır. Veriler, “Kişisel Bilgi Formu”,“Genel Sağlık Anketi” ve “Bilinçli Farkındalık Ölçeği” ile toplanmıştır. İstatistiksel değerlendirmede; Bağımsız Örneklem T Testi, Tek Yönlü Varyans Analizi (ANOVA), Tukey Testi ve Pearson Korelasyon Katsayısı kullanılmıştır.
Bulgular: Kadınların %52,8’i 18-30 yaş aralığında ve %38,7’si lise mezunudur. Yapılan istatistiksel değerlendirmede; bilinçli farkındalık toplam puanı ile genel sağlık algısı toplam puanı arasında orta düzeyde negatif yönde (r=-0,414; p
Gradually decreasing daylength after smoltification induced by “winter signal“ reduced sexual maturation in male Atlantic salmon
Authors: Skjold Vetle , Rørvik Kjell-Arne , Sveen Lene , Burgerhout Erik , Mota Vasco C. , Weihe Rúni , Ytrestøyl Trine , Bou Marta , Jacobsen Hans Jákup , Allaoui Giovanni , Fuskevåg Ole-Martin , Dessen Jens-Erik 
Published: January 2024

IntroductionMaturation in seawater-adapted (smoltified) male Atlantic salmon is undesirable yet frequently reported in fish weighing up to 1 kg reared under intensive conditions in land-based facilities. Although the photoperiod regulates both smoltification and maturation, the optimal post-smoltification regimen for the prevention of maturation is unclear.MethodsIn this study, mixed-sex Atlantic salmon weighing 95 g were exposed to three different photoperiod regimes: continuous daylength, gradually decreasing daylength, and short-to-long daylength after the induction of smoltification by the “winter signal” (12 h:12 h light:dark). Fish were maintained under these conditions in triplicate for 18 weeks in a brackish water flow-through system at 12°C and with a salinity of 20 ppt. This initial phase was followed by a grow-out period (1 kg–2.5 kg) in seawater (32-ppt salinity) at 13°C for 11 weeks, with exposure to decreasing daylength. Throughout the 29-week study, body condition, gonad development, and morphological traits were assessed. Additionally, during exposure to brackish water, serum 11-ketotestosterone (11-KT) levels were quantified, and the testes were examined histologically. Upon termination of the study, the maturation rate was determined.ResultsThis study exclusively detected maturation among male salmon. Under continuous light exposure, the number of fish initiating maturity steadily increased from week 8 and continued to increase in the subsequent samplings. In the short-to-long daylength group, a subset of male fish showed elevated 11-KT levels at week 14, although their gonadal development and morphological changes were not evident until week 18. Male fish exposed to decreasing daylength showed no substantial increase in 11-KT levels, although a few fish exhibited advanced gonad development by week 18. At the end of the trial, markedly lower percentages of maturing and fully mature male fish were observed among those fish previously exposed to decreasing daylength. The maturation rates at study termination were 44.4% for the short-to-long daylength group, 29.4% for the continuous daylength group, and 4.3% for the decreasing daylength group.DiscussionThese results show that photoperiod can be utilized to regulate maturation in male Atlantic salmon. In addition, decreasing the photoperiod after smoltification seems to limit early sexual maturation without compromising body size development. Thus, decreasing the photoperiod could be utilized to limit maturation in the production of post-smolt salmon or salmon in land-based facilities.
Clinical cure induced by pegylated interferon α-2b in the advantaged population of chronic hepatitis B virus infection: a retrospective cohort study
Authors: Wen Chaojing , Wang Yixuan , Tian Haoyue , Lei Yu , Wang Zhiyi , Cai Dachuan , Zhou Zhi , Shi Xiaofeng 
Published: January 2024

BackgroundAmong the advantaged population with clinical cure of chronic hepatitis B, chronic inactive hepatitis B virus carriers (IHCs) and nucleoside analog-experienced patients have similar serological manifestations. This study established non-interferon-treated groups as controls to compare the efficacy of pegylated interferon α-2b (Peg-IFNα-2b) in achieving clinical cure between IHCs and nucleoside analog (NA)-experienced patients.MethodA total of 270 patients were enrolled in this observational study. The IHC cohort comprised 55 patients who received Peg-IFNα-2b (Peg-IFN group), and the other 70 patients did not receive any antiviral treatment (untreated group). Patients treated with NAs were divided into two groups: one group (70 patients) receiving NA add-on Peg-IFNα-2b therapy regimen (NA add-on Peg-IFN group) and another group (75 patients) receiving continuous NA monotherapy (NA group). The primary endpoints were hepatitis B surface antigen (HBsAg) clearance and HBsAg seroconversion at 48 weeks and 72 weeks.ResultsAt 48 weeks, 65.5% (36/55) and 52.9% (37/70) patients achieved HBsAg clearance in the Peg-IFN group and NA add-on Peg-IFN group, respectively (p = 0.156). HBsAg seroconversion was achieved in 47.3% (26/55) of the Peg-IFN group and 34.3% (24/70) of the NA add-on Peg-IFN group (p = 0.141). At the follow-up of 72 weeks, 36 patients in the Peg-IFN group achieved HBsAg loss (65.5%, 36/55), and 33 patients in the NA add-on Peg-IFN group achieved HBsAg clearance (47.1%, 33/70), which were significantly higher than in the Peg-IFN group (p = 0.041). The HBsAg seroconversion rates in the Peg-IFN group and NA add-on Peg-IFN group at 72 weeks were 45.5% (25/55) and 32.9% (23/70), respectively (p = 0.151). No patient achieved HBsAg clearance or seroconversion in the NA group and untreated group. Furthermore, the receiver operating characteristic curve showed baseline HBsAg&lt; 72 IU/mL, and the decline of HBsAg of more than 80% and 98% from baseline to 12 and 24 weeks provided good predictions for HBsAg clearance. Meanwhile, 77% of patients with baseline HBsAg&lt; 100 IU/mL achieved a clinical cure at 48 weeks.ConclusionPeg-IFNα-2b results in a high rate of HBsAg clearance and seroconversion in both IHCs and NA-experienced patients, especially for those patients who have HBsAg below 100 IU/mL.