bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microscopic shell-model description of irrotational-flow dynamics in 102Pd
Authors: Ganev H. G. 
Published: October 2023

Abstract
The structure of the low-lying collective excitations in

Pd is examined within the recently proposed microscopic shell-model version of the Bohr-Mottelson (BM) collective model. A good description of the excitation energies of the lowest ground, γ, and β bands, as well as the staggering function between the collective states of the γ band and some other energy-dependent quantities, is obtained. The low-energy intraband and interband quadrupole dynamics is reasonably well described within the present proton-neutron sympletic based shell-model approach without the use of an effective charge and compared with the predictions of nuclear structure models. The obtained results of the present study shed light on the question of the existence of irrotational-flow type quadrupole dynamics, which lies on the ground of the original BM model of quantized vibrations and surface-wave rotations in atomic nuclei.
Benchmarking single-cell hashtag oligo demultiplexing methods
Authors: Howitt George , Feng Yuzhou , Tobar Lucas , Vassiliadis Dane , Hickey Peter , Dawson Mark A , Ranganathan Sarath , Shanthikumar Shivanthan , Neeland Melanie , Maksimovic Jovana , Oshlack Alicia 
Published: October 2023

Abstract
Sample multiplexing is often used to reduce cost and limit batch effects in single-cell RNA sequencing (scRNA-seq) experiments. A commonly used multiplexing technique involves tagging cells prior to pooling with a hashtag oligo (HTO) that can be sequenced along with the cells’ RNA to determine their sample of origin. Several tools have been developed to demultiplex HTO sequencing data and assign cells to samples. In this study, we critically assess the performance of seven HTO demultiplexing tools: hashedDrops, HTODemux, GMM-Demux, demuxmix, deMULTIplex, BFF (bimodal flexible fitting) and HashSolo. The comparison uses data sets where each sample has also been demultiplexed using genetic variants from the RNA, enabling comparison of HTO demultiplexing techniques against complementary data from the genetic ‘ground truth’. We find that all methods perform similarly where HTO labelling is of high quality, but methods that assume a bimodal count distribution perform poorly on lower quality data. We also suggest heuristic approaches for assessing the quality of HTO counts in an scRNA-seq experiment.
Establishment of Hp(3) calibration system for eye dose monitoring in Taiwan
Authors: Wu Chiao-An , Chiu Min-Chi , Huang Tseng-Te , Lin Yi-Chun , Chu Chien-Hau 
Published: October 2023

Abstract
In response to the ICRP’s amending the occupational exposure limit for the eye lens, the Institute of Nuclear Energy Research (INER) established the Hp(3) calibration system for eye dose monitoring in Taiwan to accurately assess the dose received in the eye lens. INER employed the narrow-spectrum series radiation according to the ISO 4037 as the X-ray radiation qualities, and the measured half-value layer consistent with a 5% difference. The air kerma rate standard was determined by the self-made free air chamber, and through dose conversion coefficient referring to ISO 4037 to obtain the Hp(3) on an ISO cylinder phantom. Furthermore, the calibration system was provided as the characteristics tests for DOSIRIS headset dosemeters. Finally, the Hp(3) calibration system has been established in Taiwan, and it can be used to provide calibration services for eye lens dosemeters and be applied to the proficiency testing that will be held in 2023.
Simulation of Hp(0,07) beta and photon response of a BeOSL finger ring dosemeter
Authors: Bandalo Vedran , Hoedlmoser Herbert 
Published: October 2023

Abstract
Simulation of a dosemeter’s energy and angular response lowers development cost and time. To support development of a new beta sensitive dosemeter we simulate both the dosemeter and the skin dose in a rod phantom as there are no fluence to dose conversion coefficients in the ICRU Report 47 for electrons. Published spectra for BSS2, N-Series and S-Cs and S-Co were used to define sources, with CAD models used to define the simulation geometry. Simulation tools were validated with experimental beta and photon responses available for the BeOSL photon ring. The developed toolchain was then used to simulate several iterations of a beta sensitive detector element inside a beta ring holder, with the goal to minimise the need for repeated prototype fabrication and characterisation. Simulation results for the final design were compared to measurements on 3D printed prototypes with all radiation qualities, except 90Sr/90Y 0°, falling within measurement uncertainty.
A review of Merkel cell carcinoma
Authors: Juan Hui Yu , Khachemoune Amor 
Published: October 2023

ABSTRACT
Merkel cell carcinoma (MCC) is a rare and aggressive type of metastatic, nonmelanoma skin cancer derived from Merkel cells in the epidermis. MCC can be induced by sun exposure or via Merkel cell polyomavirus (MCV) gene expression. MCV is found in most patients with MCC and is associated with a lower recurrence rate of MCC. MCC has a wide range of clinical presentations that make diagnosis challenging. Histologic examination is performed using unique markers to differentiate it from other diagnoses. This article reviews the pathogenesis, clinical presentation, histopathology, differential diagnosis, and treatment of MCC.
Postoperative Opioid Prescribing Practices and Patient Opioid Utilization in Pediatric Orthopaedic Surgery Patients
Authors: Mullen Marguerite A. , Kim Kang Woo , Procaccini Michaela , Shipp Michael M. , Schiller Jonathan R. , Eberson Craig P. , Cruz Aristides I. 
Published: October 2023

Introduction:
Amid a national opioid epidemic, it is essential to review the necessity of opioid prescriptions. Research in adults has demonstrated patients often do not use their entire postoperative opioid prescription. Limited data suggest that the trend is similar in children. This study investigated the prescription volume and postoperative utilization rate of opioids among pediatric orthopaedic surgery patients at our institution.

Methods:
We identified pediatric patients (ages below 18 y old) who presented to our institution for operating room intervention from May 24, 2021, to December 13, 2021. Patient demographics and opioid prescription volume were recorded. Parents and guardians were surveyed by paper “opioid diary” or phone interview between postoperative days 10 to 15, assessing pain level, opioid use, and plans for remaining opioid doses. Wilcoxon rank-sum test, Independent t test, and Pearson correlation were used for the analysis of continuous variables. Multivariable logistic regression was used to control for patient demographic variables while analyzing opioid usage relationships.

Results:
Prescription volume information was collected for 280 patients during the study period. We were able to collect utilization information for 102 patients (Group 1), whereas the remaining 178 patients contributed only prescription volume data (Group 2). Patients with upper extremity fractures received significantly fewer opioid doses at discharge compared with other procedure types (P=0.036). Higher BMI was positively correlated with more prescribed opioid doses (R
2=0.647, P<0.001). The mean opioid utilization rate was 22.37%. A total of 50.6% of patients prescribed opioids at discharge used zero doses. A total of 96.2% of patients used opioids for 5 days or less. Most families had not disposed of excess medication by postoperative day 10.

Conclusions:
We found significant differences in opioid prescribing practices based on patient and procedure-specific variables. In addition, although our pediatric orthopaedic surgery patients had low overall rates of postoperative opioid utilization, there was significant variation in opioid use among procedure types. These results provide insights that can guide opioid prescribing practices for pediatric orthopaedic patients and promote patient education to ensure safe opioid disposal.
Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopedic Surgery
Authors: Koritz Katherine , Canizares Maria Fernanda , Cook Danielle , Shore Benjamin J. 
Published: October 2023

Background:
Dermabond (Dermabond; Ethicon, Sommerville, NJ), is a skin adhesive commonly utilized in pediatric orthopedic surgery for postoperative wound care. Few studies have examined outcomes of Dermabond exposure in children. The purpose of this study is to estimate the incidence of skin reactions following Dermabond exposure in pediatric orthopedic surgery and investigate potential risk factors associated with Dermabond sensitivity.

Methods:
This was a retrospective study of a level-one pediatric trauma center. All orthopaedic surgeries in 2019 were screened for Dermabond application. Three surgeons with the highest rates of Dermabond application defined our cohort. Out of 2990 surgeries in 2019, the 3 surgeons performed 234 surgeries with Dermabond. Postoperative reactions and repeat Dermabond exposures were collected for these 234 patients. Subjects with known allergies to Dermabond were excluded. Reactions were defined. as discoloration, irritation, and wound dehiscence. Significant differences between patients with repeat Dermabond exposures and those without were determined using χ2 analysis. Associations between patient characteristics and sensitivity were determined using logistic regression analysis. P values less than 0.05 were considered significant.

Results:
In all, 234 patients were included for analysis. The mean age at surgery was 12.5 years (SD 6.1), and 39% (92/234) of the cohort was male. Thirty-two patients (14%) experienced skin reactions during the study period (95% CI=7%–19%). Reactions most frequently included. erythema (10/32; 31%) and itchiness (10/32; 31%). Reactions were most frequently treated with oral antibiotics, Benadryl, or a dressing change. Of 144 patients with 1 Dermabond exposure, 17 (12%) experienced reactions (95% CI=7%–18%). Of 128 patients experiencing a repeat Dermabond exposure, 27 (21%) experienced reactions (95% CI=19%–34%, P=0.03). Age, surgical procedure, and surgical location were not, associated with a variable rate of sensitivity.

Conclusions:
Sensitivity to Dermabond after pediatric orthopedic surgery occurred at a higher rate than seen in adults, and patients with multiple Dermabond exposures experienced significantly higher sensitivity than patients with a single exposure. Increased awareness of this potential complication is needed to help inform decisions regarding Dermabond’s application in pediatric orthopedics.
The Relationship between the Bevel of the Radial Head Epiphysis and the Posterior Synovial Fringe During Rotation of the Elbow: An Ultrasonography Study with Possible Implications Regarding the Pathophysiology of Nursemaid’s Elbow
Authors: Tsai Chia-Che , Chiang Yi-Pin 
Published: October 2023

Background:
Nursemaid’s elbow is the most common upper extremity injury in children under 5 years of age. However, the exact pathomechanism underlying the nursemaid’s elbow remains elusive, and approximate one-third of patients present with a nonclassical history. Using a high-frequency ultrasound probe, we attempted to determine the relationship between the anterior edge of the posterior synovial fringe and the peripheral rim of the radial head epiphysis during rotation. It is possible that the primary reason for the nursemaid’s elbow is due to the pronator position.

Methods:
Twenty-one patients had a history of nursemaid’s elbow and had a successful reduction before enrollment in this study. A high-frequency linear array 6 to 24 MHz hockey stick transducer was used to detect small morphologic changes in the peripheral rim of the radial head epiphysis and the posterior synovial fringe during rotation of the capitellum-radial joint.

Results:
In complete pronation, the anterior edge of the posterior synovial fringe contacts the beveled articular surface of the radial head peripheral rim in all 21 patients. In neutral and complete supination, the anterior edge of the posterior synovial fringe contacts the convexly nonarticular surface of the radial head peripheral rim and extends deep into the foveal radius. The posterior synovial fringe and the capsule-aponeurotic membrane were tightened in passive pronation in all 21 cases. The posterior synovial fringe and the capsule-aponeurosis membrane were all loose in the neutral and supination positions.

Conclusion:
The anterior edge of the posterior synovial fringe touches the beveled peripheral rim of the radial head epiphysis during complete pronation, and the tension of the lateral collateral ligament complex during pronation may further cause unstable conditions of the anterior edge of the posterior synovial fringe. We hypothesized that the beveled peripheral rim of the radial epiphysis and its relationship with the anterior edge of the posterior synovial fringe could be the reason why nursemaid’s elbow only occurs while the elbow is in the pronator position.
Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease
Authors: Mrdjen Marko , Huang Emily , Pathak Vai , Bellar Annette , Welch Nicole , Dasarathy Jaividhya , Streem David , McClain Craig J. , Mitchell Mack , Radaeva Svetlana , Barton Bruce , Szabo Gyongyi , Dasarathy Srinivasan , Wang Zeneng , Hazen Stanley L. , Brown J. Mark , Nagy Laura E. 
Published: October 2023

Background:
Chronic alcohol consumption impairs gut barrier function and perturbs the gut microbiome. Although shifts in bacterial communities in patients with alcohol-associated liver disease (ALD) have been characterized, less is known about the interactions between host metabolism and circulating microbe-derived metabolites during the progression of ALD.

Methods:
A large panel of gut microbiome-derived metabolites of aromatic amino acids was quantified by stable isotope dilution liquid chromatography with online tandem mass spectrometry in plasma from healthy controls (n = 29), heavy drinkers (n = 10), patients with moderate (n = 16) or severe alcohol-associated hepatitis (n = 40), and alcohol-associated cirrhosis (n = 10).

Results:
The tryptophan metabolites, serotonin and indole-3-propionic acid, and tyrosine metabolites, p-cresol sulfate, and p-cresol glucuronide, were decreased in patients with ALD. Patients with severe alcohol-associated hepatitis and alcohol-associated cirrhosis had the largest decrease in concentrations of tryptophan and tyrosine-derived metabolites compared to healthy control. Western blot analysis and interrogation of bulk RNA sequencing data from patients with various liver pathologies revealed perturbations in hepatic expression of phase II metabolism enzymes involved in sulfonation and glucuronidation in patients with severe forms of ALD.

Conclusions:
We identified several metabolites decreased in ALD and disruptions of hepatic phase II metabolism. These results indicate that patients with more advanced stages of ALD, including severe alcohol-associated hepatitis and alcohol-associated cirrhosis, had complex perturbations in metabolite concentrations that likely reflect both changes in the composition of the gut microbiome community and the ability of the host to enzymatically modify the gut-derived metabolites.
Noncanonical regulation of HOIL-1 on cancer stemness and sorafenib resistance identifies pixantrone as a novel therapeutic agent for HCC
Authors: Chen Peng , Dong Zheyu , Zhu Wei , Chen Junling , Zhou Yuxin , Ye Qiuyue , Liao Xinxin , Tan Yongfa , Li Chuanjiang , Wang Yuhao , Pang Huajin , Wen Chunhua , Jiang Yuchuan , Li Xiaoqing , Li Bo , Aimaier Aihetaimu , Lin Li , Sun Jian , Hou Jiajie , Tang Libo , Hou Jinlin , Li Yongyin 
Published: October 2023

Background and Aims:
Cancer stem cells (CSCs) contribute to therapy resistance in HCC. Linear ubiquitin chain assembly complex (LUBAC) has been reported to accelerate the progression of cancers, yet its role in the sorafenib response of HCC is poorly defined. Herein, we investigated the impact of LUBAC on sorafenib resistance and the CSC properties of HCC, and explored the potential targeted drugs.

Approach and Results:
We found that HOIL-1, but not the other components of LUBAC, played a contributing role in LUBAC-mediated HCC sorafenib resistance, independent of its ubiquitin ligase activity. Both in vitro and in vivo assays revealed that the upregulated HOIL-1 expression enhanced the CSC properties of HCC. Mechanistically, HOIL-1 promoted sorafenib resistance and the CSC properties of HCC through Notch1 signaling. Mass spectrometry, co-immunoprecipitation, western blot, and immunofluorescence were used to determine that the A64/Q65 residues of HOIL-1 bound with the K78 residue of Numb, resulting in impaired Numb-mediated Notch1 lysosomal degradation. Notably, pixantrone was screened out by Autodock Vina, which was validated to disrupt HOIL-1/Numb interaction to inhibit Notch1 signaling and CSC properties by targeting the Q65 residue of HOIL-1. Moreover, pixantrone exerted synergistic effects with sorafenib for the treatment of HCC in different HCC mouse models.

Conclusions:
HOIL-1 is critical in promoting sorafenib resistance and CSC properties of HCC through Notch1 signaling. Pixantrone targeting HOIL-1 restrains the sorafenib resistance and provides a potential therapeutic intervention for HCC.
Acupuncture Legislation in the United States: Minnesota as a Case Study
Authors: Gong Changzhen 
Published: October 2023

Abstract
2023 marks the 50th anniversary of legal regulation of acupuncture in the United States, as the first acupuncture law was enacted in Nevada. Acupuncture, like any other medical modality, is regulated at the state level, with each state formulating and enforcing its own laws and statutes over time. This article narrates the legislative process and major developments of the acupuncture profession in Minnesota, in the context of legislative developments across the country. It tells how this midsize, Midwest state’s acupuncture profession became regulated, and examines the challenges faced by the profession before and after state statutes were enacted. Minnesota stands as a representative example of the legislative process in other states.
The influence of financial market development on de jure central bank independence in the Asia–Pacific
Authors: Chee-Hong Law 
Published: October 2023

PurposeThis study investigates the impact of financial development, measured by the ratio of broad money to gross domestic products, on de jure central bank (CB) independence (CBI) in 17 countries in the Asia–Pacific region from 1995 to 2014.Design/methodology/approachThis study uses the feasible generalized least squares (FGLS) approach, which is suitable since the CBI equation suffers from contemporaneous correlation, serial correlation and heteroscedasticity.FindingsThe FGLS results suggest a positive association between CBI and financial market development (FMD). This relationship is confirmed when estimating different indicators of de jure CBI and adopting the panel-corrected standard error estimate. However, the statistical significance of FMD is not supported when the ratio of domestic credit to the private sector to GDP is measured.Research limitations/implicationsIt is significant to have a developed financial system to foster a better CBI. Moreover, it is important to measure the influence of financial market players on the operations of a CB.Originality/valueThe financial market in the Asia–Pacific has improved over the years. Hence, the results show the determinants of CBI in the Asia–Pacific, especially the role of FMD.
A bibliometric analysis on the application of deep learning in finance: status, development and future directions
Authors: Manogna R.L. , Anand Aayush 
Published: October 2023

PurposeDeep learning (DL) is a new and relatively unexplored field that finds immense applications in many industries, especially ones that must make detailed observations, inferences and predictions based on extensive and scattered datasets. The purpose of this paper is to answer the following questions: (1) To what extent has DL penetrated the research being done in finance? (2) What areas of financial research have applications of DL, and what quality of work has been done in the niches? (3) What areas still need to be explored and have scope for future research?Design/methodology/approachThis paper employs bibliometric analysis, a potent yet simple methodology with numerous applications in literature reviews. This paper focuses on citation analysis, author impacts, relevant and vital journals, co-citation analysis, bibliometric coupling and co-occurrence analysis. The authors collected 693 articles published in 2000–2022 from journals indexed in the Scopus database. Multiple software (VOSviewer, RStudio (biblioshiny) and Excel) were employed to analyze the data.FindingsThe findings reveal significant and renowned authors' impact in the field. The analysis indicated that the application of DL in finance has been on an upward track since 2017. The authors find four broad research areas (neural networks and stock market simulations; portfolio optimization and risk management; time series analysis and forecasting; high-frequency trading) with different degrees of intertwining and emerging research topics with the application of DL in finance. This article contributes to the literature by providing a systematic overview of the DL developments, trajectories, objectives and potential future research topics in finance.Research limitations/implicationsThe findings of this paper act as a guide for literature review for anyone interested in doing research in the intersection of finance and DL. The article also explores multiple areas of research that have yet to be studied to a great extent and have abundant scope.Originality/valueVery few studies have explored the applications of machine learning (ML), namely, DL in finance, which is a much more specialized subset of ML. The authors look at the problem from the aspect of different techniques in DL that have been used in finance. This is the first qualitative (content analysis) and quantitative (bibliometric analysis) assessment of current research on DL in finance.
Inter-state war, institutions and multinationals: insights from the Russian-Ukraine war
Authors: Owens Martin David 
Published: October 2023

Purpose
Wars, and violent conflicts generally, can generate significant institutional dynamics and new legitimacy pressures for multinational enterprises (MNEs). The purpose of this paper is to understand the nature or source of institutional pressures facing MNEs in war and to examine how MNEs respond and navigate these institutional pressures.

Design/methodology/approach
This is a conceptual paper.

Findings
Through the theoretical lens of institutional theory and drawing on insights from the devastating Russian–Ukrainian war in Europe, the study provides a framework that explains the nature of institutional pressures impacting MNEs in a major war conflict and how MNEs respond to these pressures. Central to the framework is the impact of formal and informal institutions on MNEs during war. As a result of regulatory and social pressures, MNEs have to make important strategic decisions either to protect their legitimacy or to defend their economic objectives against institutional demands.

Originality/value
As the paper situates the pressures of war for MNEs in a formal and informal institutional context, this offers a new approach to understanding the costs and pressures of war on MNEs.