bluuebunny/crossref_metadata_2025_split huggingface dataset:
The stochastic vibration characteristics of the coupled airbag isolation system for marine rotors under heave excitation
Authors: Zhu Leilei Zhu , Li Ming Li , Du Du Xiaolei 
Published: February 2024

Abstract
This paper mainly studies the random vibration of the marine rotating machinery-airbag isolation system under pendulum excitation. Firstly, the airbag is simplified as a cubic nonlinear spring and a linear damper, considering the randomness of the spring stiffness. The random dynamic model of the system under pendulum excitation is established. Then, based on the second kind of Chebyshev orthogonal polynomial expansion approximation method and Monte Carlo method, the random vibration characteristics of the system are analyzed by comparing with the simulation results of the deterministic system. The results show that when the cubic nonlinear spring coefficient is taken as a random parameter and the pendulum excitation amplitude is small, the random perturbation of the spring nonlinear stiffness has little influence on the system, and the dynamic behavior is similar to the deterministic system. However, as the pendulum excitation amplitude increases, the difference in response between the two systems will also increase. When the pendulum excitation is added with random white noise excitation, the difference between the two systems is small and mainly reflected in the vibration velocity when the rotor speed is low. As the rotor speed increases, the difference between the two systems becomes larger, and the influence of the rotor speed on the random system is greater than that on the deterministic system.
Comparative Evaluation of Commercial DNA Isolation Approaches for Nanopore-only Bacterial Genome Assembly and Plasmid Recovery
Authors: Kruasuwan Worarat , Sawatwong Pongpun , Jenjaroenpun Piroon , Wankaew Natnicha , Arigul Tantip , Yongkiettrakul Suganya , Lunha Kamonwan , Sudjai Aunthikarn , Siludjai Duangkamon , Skaggs Beth , Wongsurawat Thidathip 
Published: February 2024

Abstract

The advent of Oxford Nanopore Technologies has undergone significant improvements in terms of sequencing costs, accuracy, and sequencing read lengths, making it a cost-effective, and readily accessible approach for analyzing microbial genomes. A major challenge for bacterial whole genome sequencing by Nanopore technology is the requirement for a higher quality and quantity of high molecular weight DNA compared to short-read sequencing platforms. In this study, using eight pathogenic bacteria, we evaluated the quality, quantity, and fragmented size distribution of extracted DNA obtained from three different commercial DNA extraction kits, and one automated robotic platform. Our results demonstrated significant variation in DNA yield and purity among the extraction kits. The ZymoBIOMICS DNA Miniprep Kit (ZM) provided a higher purity of DNA compared to other kit-based extractions. All kit-based DNA extractions were successfully performed on all twenty-four samples using a single MinION flow cell, with the Nanobind CBB Big DNA kit (NB) yielding the longest raw reads. The Fire Monkey HMW-DNA Extraction Kit (FM) and the automated Roche MagNaPure 96 platform (RO) outperformed in genome assembly, particularly in gram-negative bacteria. A minimum of 30× to 50× read coverages is recommended for genome assembly and plasmid recovery. Our evaluation indicated that the RO platform gave the best overall performance compared to other kits. The RO platform has the additional advantages of full automation and high throughput. However, consideration of upfront costs associated with instruments and reagents is crucial. In conclusion, our study provides valuable guidance for selecting effective kit-based DNA extraction methods for bacterial whole genomes and plasmids recovery.
Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery
Authors: Fujita Hiroaki , Wakiya Taiichi , Tatara Yota , Ishido Keinosuke , Sakamoto Yoshiyuki , Kimura Norihisa , Morohashi Hajime , Miura Takuya , Muroya Takahiro , Akasaka Harue , Yokoyama Hiroshi , Kanda Taishu , Kubota Shunsuke , Ichisawa Aika , Ogasawara Kenta , Kuwata Daisuke , Takahashi Yoshiya , Nakamura Akie , Yamazaki Keisuke , Yamada Takahiro , Matsuyama Ryo , Kanou Masanobu , Yamana Kei , Itoh Ken , Hakamada Kenichi 
Published: February 2024

Abstract

Nicotinamide adenine dinucleotide (NAD+) plays a pivotal role in numerous cellular functions. Reduced NAD+ levels are postulated to be associated with cancer. As interest in understanding NAD+ dynamics in cancer patients with therapeutic applications in mind grows, there remains a shortage of comprehensive data. This study delves into NAD+ dynamics in patients undergoing surgery for different digestive system cancers. This prospective study enrolled 99 patients with eight different cancers. Fasting blood samples were obtained during the perioperative period. The concentrations of NAD+, nicotinamide mononucleotide (NMN), and nicotinamide riboside were analyzed using tandem mass spectrometry. Initial measurements showed lower NAD+ concentrations in cancer patients compared to previously studied healthy donors. After erythrocyte volume adjustment, NAD+ remained relatively stable after surgery. Meanwhile, NMN decreased the day after surgery and displayed a recovery trend. Interestingly, liver and pancreatic cancer patients exhibited poor postoperative NMN recovery, suggesting a potential cancer type-specific influence on NAD+ metabolism. This study illuminated the behavior of NAD+ in surgically treated cancer patients. We identified which cancer types have particularly low levels and at what point depletion occurs during the perioperative period. These insights suggest the need for personalized NAD+ supplementation strategies, calibrated to individual patient needs and treatment timelines.
Clinical trial registration
jRCT1020210066
Development of optical fiber vector sensor and its application in straightness monitoring of scraper conveyor
Authors: Du Shangyu , Shi Hongyu 
Published: February 2024

Abstract
The accuracy of straightness monitoring of scraper conveyor seriously restricts the development of unmanned mining technology in underground coal mines. Fiber Bragg Grating sensors have the characteristics of passive intrinsic safety and have broad application prospects in coal mine underground monitoring technology. In this paper, the motion characteristics between two adjacent scrapers of the scraper were fully analyzed, the mathematical expressions were illustrated, furthermore, we designed and manufactured a 3D vector sensor using FBG sensors. The calibration and testing of the appropriate amount of sensor was realized, and the test results showed that the fiber vector sensor we designed can be used to measure the straightness of the scraper conveyor.
Intratumoral Administration Immunogenic Exosomes can Modify Tumor Immune Microenvironment
Authors: Kalami Arman , Poursalehi Zahra , Gharalari Farzaneh Hosseini , Molavi Hana , Tollabi Mohammad , Nasiri-Motlagh Behnam , Shahgolzari Mehdi , Khosroshahi Ahmad Yari 
Published: February 2024

Abstract

It has been observed that external stress or stimuli can initiate apoptosis and produce extracellular vesicles known as exosomes. Recent studies suggest that exosomes can trigger an anti-tumor immune response. In the current study, exosomes secreted by the 4T1 triple-negative breast cancer (TNBC) cell line under stress conditions (Dox, X-ray irradiation, and cold plasma treatments) were studied. The stress-induced exosomes were harvested, differing in their ability to present some DAMP proteins such as HSP70 and HMGB1. These exosomes can enhance the expression of pro-inflammatory molecules by immune cells at different levels in different treatments. Additionally, intratumoral administration of these exosomes has been shown to modify the tumor immune microenvironment (TIME) in a TNBC murine model differently. We have concluded that exosomes secreted by the 4T1 cell line under Dox treatment can significantly reduce tumor volume and modify the tumor microenvironment. However, other treatment methods produce immunogenic exosomes that are neither effective nor appropriate. Nevertheless, many studies report that these methods have significant therapeutic effects when used directly.
Effect of chronic vapor nicotine exposure on affective and cognitive behavior in male mice
Authors: Murdaugh Laura B. , Miliano Cristina , Chen Irene , Faunce Christine L. , Natividad Luis A. , Gregus Ann M. , Buczynski Matthew W. 
Published: February 2024

Abstract
Nicotine use is a leading cause of preventable deaths worldwide, and most of those who attempt to quit will relapse. While electronic cigarettes and other electronic nicotine delivery systems (ENDS) were presented as a safer alternative to traditional cigarettes and promoted as devices to help traditional tobacco smokers reduce or quit smoking, they have instead contributed to increasing nicotine use among youths. Despite this, ENDS also represent a useful tool to create novel preclinical animal models of nicotine exposure that more accurately represent human nicotine use. In this study, we validated a chronic, intermittent, ENDS-based passive vapor exposure model in mice, and then measured changes in multiple behaviors related to nicotine abstinence. First, we performed a behavioral dose curve to investigate the effects of different nicotine inter-vape intervals on various measures including body weight, locomotor activity, and pain hypersensitivity. Next, we performed a pharmacokinetic study to measure plasma levels of nicotine and cotinine following chronic exposure for each inter-vape interval. Finally, we utilized a behavior test battery at a single dosing regimen that produces blood levels equivalent to human smokers in order to characterize the effects of chronic nicotine, vehicle, or passive airflow and identified nicotine-induced impairments in cognitive behavior.
Research on Safety Input-output Efficiency of Coal Mine Enterprises based on the Four-stage DEA-MALMQUIST Model
Authors: Wang Meng , Li Meng , Liu Weiwei , Kang Jiaxu , Su Jinshuai , Shang Liyou , YU Wenguang 
Published: February 2024

Abstract
In order to systematically evaluate the rationality of safety input-output of Chinese coal enterprises, this study analyzed and investigated the safety input-output efficiency of 16 listed coal enterprises in China during the five years from 2017 to 2021. This is achieved through the classification, integration and systematic analysis of the data in the business statements disclosed by enterprises in recent years. Using four-stage DEA model and Mulmquist model, this study has important theoretical and practical significance. The research results show that :1) In general, there are some unreasonable inputs in the operation process of Chinese coal enterprises, which are mainly reflected in the lack of planning of various inputs and the behavior of resource waste. 2) The fundamental problem of unreasonable safety input and output is the waste of human resources. Under the current economic scale, the average overstaffing of the industry reaches 37.56%. In terms of enterprise operating expenses, too many personnel will lead to a further increase in security costs, management costs, scientific research costs and other costs. 3) Before 2019, the operation and development of China's coal enterprises were mainly reflected in that their own technical management level lagged behind the average level of the industry, and after 2019, it was transformed into the insufficient utilization of their own existing management technology level. This paper takes the safety input-output efficiency of Chinese coal enterprises as the starting point, and deeply discusses the rationality of enterprise input and output. This paper studies the influence of different input-output units on the operation efficiency of enterprises, and provides guidance for improving the input management level of enterprises.
Pan-cancer analysis of the role of SPC25 in human cancer
Authors: Wang Qi , Wu wensong , Aisha Awuti , Xin Jiayan , Chang Fan , Zhang Jianghui , Tang Shuai , Lv Zheng , Chen Fangmin 
Published: February 2024

Abstract
Objective
Cell division plays a crucial role in the onset and progression of cancer. Despite the significant role of SPC25 in the cell cycle, its involvement in cancer remains insufficiently studied. This research aims to employ bioinformatics analysis methods by integrating extensive multi-omics data from various cancer types to explore the potential mechanisms of SPC25 in the occurrence of diverse cancers.
Method
We conducted an extensive analysis utilizing mRNA expression data and clinical information from cancer patients obtained from the TCGA database. We examined SPC25 protein expression levels in tumor and normal samples using the UALCAN database, alongside an assessment of its promoter methylation status. Additionally, we accessed immunohistochemical images of SPC25 protein in tumor and normal tissues from the HPA database. Detailed information regarding SPC25 mutations across various tumor types was obtained from the cBioPortal database. Analysis of SPC25 expression across multiple cell types was performed using the TISCH2 database. We investigated the relationship between SPC25 expression levels and immune cell infiltration as well as the expression of immune-related factors. Furthermore, we conducted single-variable Cox regression analysis to explore the association between SPC25 and cancer patient prognosis. To delve into potential mechanisms, we employed methodologies from the GO, KEGG, GSEA, CancerSEA, and GSCALite databases to investigate SPC25's potential involvement in various cancers.
Results
Our study comprehensively examined the role of SPC25 within a multi-omics framework. SPC25 demonstrates heightened expression across diverse cancer types, showcasing robust diagnostic potential for cancer detection. Furthermore, it correlates with unfavorable prognoses across multiple cancer types and exhibits a significant association with tumor immunogenicity. Its putative role in modulating the cell cycle stands as a potential primary mechanism in cancer pathogenesis. Hence, SPC25 presents a prospective avenue for novel therapeutic interventions directed at the cell cycle.
Conclusion
In the future, SPC25 holds promise as a novel target for cell cycle-directed therapies.
Platypnea-Orthodeoxia Syndrome Due to Atrial Septal Defect with Congenital Variation in the Position of the Atrial Septum and Combined Thoracic Deformities in a Young Man
Authors: Hu Lixing , Tao Xincao , Zhou Xiaoming , Wang Jingjin , Li Xiangnan , Xiong Changming , Hu Haibo 
Published: February 2024

Abstract

Platypnea-orthodeoxia syndrome (POS) is a rare and complicated clinical entity with low recognition rate. The mechanisms of POS are broadly divided into intracardiac and intrapulmonary, while the detailed pathogenesis is less understood. Here we reported a POS case with atrial septal defect with congenital horizontal position of the atrial septum and combined thoracic deformities in a young man with normal right atrial pressure. This case was useful for understanding the detailed pathogenesis of POS.
Low-Complexity Passive Beamforming for Reconfigurable Intelligent Surface Aided mmWave communication Systems
Authors: Qi Jinyan , Li Haohan , Zhang Wence , Xia Jing , Zheng Zhaowen , Bao Xu 
Published: February 2024

Abstract

Millimeter wave (mmWave) communication technology has received wide attention in recent years due to its abundant frequency resources. However, severe propagation loss and the ease of being blocked by obstacles are not conducive to wide area coverage. Reconfigurable intelligent surface (RIS) is expected to solve the coverage problem of mmWave communication systems by reforming the wireless channel to some extent. In this work, we propose a low complexity scheme for the optimization of RIS phase shifts in the downlink of mmWave communication systems. Unlike previous works that usually jointly design the RIS phase shifts and precoding matrix with nonnegligible computational and implementation complexity, we propose to solely optimize the RIS phase shifts to maximize the overall throughput of the wireless channel and devise two low complexity RIS phase shift design schemes, i.e., TM UB-RPO and TM SCA-RPO. For TM UB-RPO, the suboptimal phase shifts are derived in closed form through theoretical analysis, while for TM SCA-RPO, the phase shifts are optimized using the successive convex approximation method, and the solution in each iteration is given in closed form. The proposed schemes can work with any conventional precoding scheme, such as zero-forcing precoding (ZF), thus can be easily deployed in existing schemes. Numerical results show that the proposed schemes outperform existing methods in terms of achievable rates while significantly reducing computational complexity.
The Effect of Novel D3 Compounds on Saliva Samples from COVID-19 Patients: A Lab Study
Authors: Feteih Sarah , Dada Ashraf , Heaphy Emily Leanore , Jan Daina , Zailaie Samar , Wali Ghassan , Rashed Zinab 
Published: February 2024

Abstract

Background:
Saliva is one of the diagnostic tools available for dental fields due to its comfortable and noninvasive nature and greater patient acceptance of all ages, especially elderly individuals, children and cancer patients, when compared to the gold standard (swabs). As cancer incidence has been increasing worldwide, the discomfort, soreness, ulcerations and dryness a patient may suffer would divert our strategy toward novel ways for increasing patient acceptance of diagnostic tools and therapy, i.e., using saliva for such purposes. Many studies have shown the antimicrobial effects of vitamin D, one of which is its antiviral effects and role in the immune system.
The aimof this study was to explore the antiviral effects of vitamin D on saliva samples collected from COVID-19-positive patients and to compare saliva and swab results to aid in the development of new policies to better serve these patients.
Methods: Inclusion criteria were as follows: saliva and swab samples collected from adult patients with a positive test for COVID-19 at the KFSH-RC in Jeddah: Department of ER, Family Medicine and Inpatients. The exclusion criteria for patients were immunocompromised and pregnant, children and those younger than 18 years of age. D3 was made at different concentrations (100 IU, 300 IU, 800 IU and 1,200 IU) and was added to the first samples in the laboratory (n=20); the rest of the swab specimens were compared to the saliva samples via RT‒PCR (total n=257).
Results: Of these, 236 participants (94.8%) had positive saliva sample test results, 7 (2.8%) had errors, and 6 (2.4%) had negative saliva sample test results. Of the 236 positive tests, 235 (99.6%) had acycle threshold (Ct values) indicating strong positive reactions, and only one value (Ct=28.86) was weak.
Conclusion: Among the 236 positive test results, 235 (99.6%) exhibited robust positive reactions, indicating a substantial positive sample size. Consequently, saliva might be considered a dependable alternative testing tool when obtaining swab samples from patients is inconvenient or challenging.
The Beaver Tail Liver – description of a rare variant with a review of its surgical and radiologic implications
Authors: Palanisamy Anugragha , Hussain Shamila , Sajeev Rikil Ambi , Yohannan Doris George , Oommen Aswathy Maria , Devi KB Usha 
Published: February 2024

Abstract
We report a rare anatomical variant of left lobe of liver – the Beaver tail liver (BTL) /Sliver of liver, in a male donor of 29 years of age. The left lobe of liver extended from midline towards the left hypochondrium, went past the midclavicular line posteriorly to twist itself as a thin layer of hepatic tissue to encircle the spleen, on its usual ‘diaphragmatic surface’, creating an unusual ‘hepatic area’ on the convex surface of the spleen. Knowledge of this variant is important for the radiologist and the physician while interpreting lesions in the left hypochondriac region of the abdomen, especially in the setting of a left sided abdominal trauma or left lower rib fractures. Ultrasound and CT examinations of the BTL may mimic a subcapsular hematoma and caution must be exercised before diagnosing it as a splenic laceration leading to unnecessary surgical exploration. Knowledge of this variant is also important for the surgeon while surgically exploring the upper abdomen and also for choosing the appropriate liver tissue in a case of liver transplant.
Unraveling Incommensurate Spatial Partitions: A Bipartite Graph Approach to School-Neighborhood Interactions and Their Impacts
Authors: Rey Sergio , Knaap Elijah , Neal Zachary , Andris Clio 
Published: February 2024

Abstract

This paper investigates the challenges and opportunities arising from incommensurate spatial partitions (ISPs) in regional science and spatial econometrics, focusing on how processes with overlapping yet distinct boundaries, interact and influence each other. ISPs are prevalent in various domains, including housing markets, employment centers, voting districts, and educational institutions, often complicating spatial econometric modeling and analysis. Using the intersection of school catchment areas and neighborhoods as a primary case study, the paperintroduces a novel methodological framework utilizing bipartite graphs.This approach reframes the relationship between different spatial units,allowing for the analysis of multi-process spatial contexts withoutneeding harmonization of spatial supports. The paper also develops newspatial weights derived from the bipartite graph, facilitating bothexploratory spatial data analysis and confirmatory spatial econometricmodeling. The paper's contributions include a set of new modelspecifications that consider spillovers from and to each of theprocesses involved, demonstrating the application of these methodsthrough a case study in San Diego, California. This involves analyzing198 neighborhoods and 370 public elementary school catchments, exploringthe implications of school-neighborhood interactions on educational outcomes and neighborhood characteristics.
The calcaneofibular ligament courses toward the groove at the inferior fibula and the CFL groove becomes a landmark for ultrasonography
Authors: Kakegawa Akira , Sumitomo Norimi , Nagira Ayata , Ichinose Yuko , Fukushima Nanae 
Published: February 2024

Abstract
Purpose Calcaneofibular fibular ligament (CFL) injuries are harder to diagnose than anterior talofibular ligament (ATFL) ones. This study aimed to clarify the fibular attachment of the CFL and verify the bony landmark for evaluating the CFL on ultrasonography.Methods To confirm the control function of the CFL, we performed passive movement manually using cadaveric ankles and observed the ankle positions where the CFLs were tense. The ATFL and CFL were removed, and the bone morphology of the CFL attachment and inferior fibular end was imaged using a stereomicroscope and a 3D scanner. Using ultrasonography, we evaluated the bone morphology of the fibular attachment of the CFL in short-axis images of healthy adult ankles.Results The CFL was tensed according to ankle motions: supination, maximum dorsi flexion, maximum plantar flexion, and mild plantar flexion–external rotation. Below the CFL attachment of the fibula was a slight groove between the inferior tip and the obscure tubercle of the fibula. This groove was observed in 81.5% of cases using short-axis ultrasonography.Conclusion The CFL was tensed in various ankle positions to control the movements of the talocrural and subtalar joints. There was a slight groove at the inferior end of the fibula where the CFL coursed downward. We called it the CFL groove and proposed that it could serve as a landmark for the short-axis image of ultrasonography.