bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration
Authors: Lee Jung Hyun , Choi Sekyu 
Published: January 2024

AbstractHair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods of regeneration, degeneration, and rest throughout adult life in mammals. The crucial function of hair follicle stem cells is to maintain these hair growth cycles. Another vital aspect is the activity of melanocyte stem cells, which differentiate into melanin-producing melanocytes, contributing to skin and hair pigmentation. Sebaceous gland stem cells also have a pivotal role in maintaining the skin barrier by regenerating mature sebocytes. These stem cells are maintained in a specialized microenvironment or niche and are regulated by internal and external signals, determining their dynamic behaviors in homeostasis and hair follicle regeneration. The activity of these stem cells is tightly controlled by various factors secreted by the niche components around the hair follicles, as well as immune-mediated damage signals, aging, metabolic status, and stress. In this study, we review these diverse stem cell regulatory and related molecular mechanisms of hair regeneration and disease conditions. Molecular insights would provide new perspectives on the disease mechanisms as well as hair and skin disorder treatment.
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity
Authors: Yuan Tao , Zeng Chenming , Liu Jiawei , Zhao Chenxi , Ge Fujing , Li Yuekang , Qian Meijia , Du Jiamin , Wang Weihua , Li Yonghao , Liu Yue , Dai Xiaoyang , Zhou Jianya , Chen Xueqin , Ma Shenglin , Zhu Hong , He Qiaojun , Yang Bo 
Published: January 2024

AbstractNon-small cell lung cancer (NSCLC) ranks as one of the leading causes of cancer-related deaths worldwide. Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment, these drugs are suitable for and beneficial to a mere ~30% of NSCLC patients. Consequently, the need for novel strategies addressing NSCLC remains pressing. Deubiquitinases (DUBs), a group of diverse enzymes with well-defined catalytic sites that are frequently overactivated in cancers and associated with tumorigenesis and regarded as promising therapeutic targets. Nevertheless, the mechanisms by which DUBs promote NSCLC remain poorly understood. Through a global analysis of the 97 DUBs’ contribution to NSCLC survival possibilities using The Cancer Genome Atlas (TCGA) database, we found that high expression of Josephin Domain-containing protein 2 (JOSD2) predicted the poor prognosis of patients. Depletion of JOSD2 significantly impeded NSCLC growth in both cell/patient-derived xenografts in vivo. Mechanically, we found that JOSD2 restricts the kinase activity of LKB1, an important tumor suppressor generally inactivated in NSCLC, by removing K6-linked polyubiquitination, an action vital for maintaining the integrity of the LKB1-STRAD-MO25 complex. Notably, we identified the first small-molecule inhibitor of JOSD2, and observed that its pharmacological inhibition significantly arrested NSCLC proliferation in vitro/in vivo. Our findings highlight the vital role of JOSD2 in hindering LKB1 activity, underscoring the therapeutic potential of targeting JOSD2 in NSCLC, especially in those with inactivated LKB1, and presenting its inhibitors as a promising strategy for NSCLC treatment.
Resolving electron and hole transport properties in semiconductor materials by constant light-induced magneto transport
Authors: Musiienko Artem , Yang Fengjiu , Gries Thomas William , Frasca Chiara , Friedrich Dennis , Al-Ashouri Amran , Sağlamkaya Elifnaz , Lang Felix , Kojda Danny , Huang Yi-Teng , Stacchini Valerio , Hoye Robert L. Z. , Ahmadi Mahshid , Kanak Andrii , Abate Antonio 
Published: January 2024

AbstractThe knowledge of minority and majority charge carrier properties enables controlling the performance of solar cells, transistors, detectors, sensors, and LEDs. Here, we developed the constant light induced magneto transport method which resolves electron and hole mobility, lifetime, diffusion coefficient and length, and quasi-Fermi level splitting. We demonstrate the implication of the constant light induced magneto transport for silicon and metal halide perovskite films. We resolve the transport properties of electrons and holes predicting the material’s effectiveness for solar cell application without making the full device. The accessibility of fourteen material parameters paves the way for in-depth exploration of causal mechanisms limiting the efficiency and functionality of material structures. To demonstrate broad applicability, we further characterized twelve materials with drift mobilities spanning from 10–3 to 103 cm2V–1s–1 and lifetimes varying between 10–9 and 10–3 seconds. The universality of our method its potential to advance optoelectronic devices in various technological fields.
One-dimensional single atom arrays on ferroelectric nanosheets for enhanced CO2 photoreduction
Authors: Liu Lizhen , Hu Jingcong , Ma Zhaoyu , Zhu Zijian , He Bin , Chen Fang , Lu Yue , Xu Rong , Zhang Yihe , Ma Tianyi , Sui Manling , Huang Hongwei 
Published: January 2024

AbstractSingle-atom catalysts show excellent catalytic performance because of their coordination environments and electronic configurations. However, controllable regulation of single-atom permutations still faces challenges. Herein, we demonstrate that a polarization electric field regulates single atom permutations and forms periodic one-dimensional Au single-atom arrays on ferroelectric Bi4Ti3O12 nanosheets. The Au single-atom arrays greatly lower the Gibbs free energy for CO2 conversion via Au-O=C=O-Au dual-site adsorption compared to that for Au-O=C=O single-site adsorption on Au isolated single atoms. Additionally, the Au single-atom arrays suppress the depolarization of Bi4Ti3O12, so it maintains a stronger driving force for separation and transfer of photogenerated charges. Thus, Bi4Ti3O12 with Au single-atom arrays exhibit an efficient CO production rate of 34.15 µmol·g−1·h−1, ∼18 times higher than that of pristine Bi4Ti3O12. More importantly, the polarization electric field proves to be a general tactic for the syntheses of one-dimensional Pt, Ag, Fe, Co and Ni single-atom arrays on the Bi4Ti3O12 surface.
Intestinal helminthiasis, anaemia and associated risk factors in a cross-section of the population of Melong, Littorial Region of Cameroon
Authors: Tofel Haman Katamssadan , Abongwa Lem Edith , Ndifor Ruth Fri , Ntonifor Helen Ngum 
Published: January 2024

AbstractAssessment of risk factors of intestinal helminths and anaemia in various geographical regions is important for the development of appropriate control strategies. This study aimed at determining the risk factors associated with intestinal helminths and anaemia in Melong, Cameroon. A total of 325 participants were recruited in this study between September–December 2021. Faecal samples were examined using the formol-ether sedimentation technique while haemoglobin level was measured using a HemoCue spectrometer. Data on demographic and behavioural factors was collected and used to determine the risk factors using a pretested structured questionnaire and analysed using SPSS. The overall prevalence of intestinal helminths was 24.6% (80/325). Helminths recovered from the study included hookworm (16%; 52/325), Schistosoma mansoni(10.8% 35/325) Ascaris lumbricoides(1.9%; 6/325), andTrichuris trichiura(0.6%; 2/325) with 15 participants having multiple infections (4.6%). The geometric mean egg density was 77epg and ranged from 20 to 560 epg of faeces. Males and age group ≤ 5 years had the highest parasite intensity (248epg). The overall prevalence of anaemia was 33.5% (109/325). Anaemia was significantly (p = 0.001) high at 48.8% (39/80) in those infected with intestinal parasites compared to non-infected individuals. Age group of 31–45 years; [3.42(1.05–11.21)] and > 65 years [6.21(1.75–12.47)], poor knowledge [0.41(0.67–6.07)], no regular deworming [0.70(1.76–21.96)], mud floors toilet [6.18(1.61–23.79)], toilets made of sticks [16.5(4.24–64.31)], and participants who did not have stomach/abdominal pains [0.22(0.07–0.67)] were significant predictors of helminth infections. Age group < 15 years [2.58(1.09–6.11)], geophagia [3.69(1.91–9.33)], hookworm infection [3.26(1.49–7.11)],S. mansoni[1.72 (1.16–3.41)] and those with multiple infections [1.76(1.04–2.88)] were identified as risk factors for anaemia. Risk factors identified in this study can be used to improve the control mechanism put in place by the government.
Association of proton pump inhibitor use with survival and adverse effects outcomes in patients with multiple myeloma: pooled analysis of three clinical trials
Authors: Almansour Sara A. , Alqudah Mohammad A. Y. , Abuhelwa Ziad , Al-Shamsi Humaid O. , Semreen Mohammad H. , Bustanji Yasser , Soare Nelson C. , McKinnon Ross A. , Sorich Michael J. , Hopkins Ashley M. , Abuhelwa Ahmad Y. 
Published: January 2024

AbstractProton pump inhibitors (PPIs) are commonly used in cancer patients, but their impact on treatment outcomes in multiple myeloma (MM) patients remains unclear. This study investigated the association of PPI use with survival and adverse effects in MM patients across three randomized-control trials initiating daratumumab, lenalidomide, or bortezomib combination treatments. Cox proportional hazard analysis and logistic regression were employed to assess the associations with treatment outcomes, while adjusting for age, sex, weight, MM international staging system stage, ECOG-performance status, comorbidity count, and presence of gastrointestinal disorders. Pooled data involving 1804 patients revealed that 557 (32%) used PPIs at baseline. PPI use was independently associated with worse overall survival (adjusted HR [95% CI] 1.32 [1.08–1.62], P = 0.007) and grade ≥ 3 adverse events (adjusted OR [95% CI] 1.39 [1.03–1.88], P = 0.030). However, the association with progression-free survival did not reach statistical significance (adjusted HR [95% CI] 1.14 [0.97–1.33], P = 0.112). Findings were consistent across trials and treatment arms. PPI use was identified as a negative prognostic factor in MM patients, potentially enhancing clinical decisions regarding its use. Further research is needed to fully comprehend the impacts and safety of PPI use in MM patients.
Nonzero spontaneous electric polarization in metals: novel predictive methods and applications
Authors: Rahimi Shahrbano , Jalali-Asadabadi S. , Blaha Peter , Jalali-Asadabadi Farhad 
Published: January 2024

AbstractFerroelectricity in metals has advanced since the initial discovery of nonmagnetic ferroelectric-like metal LiOsO$$_3$$

3

, anchored in the Anderson and Blount prediction. However, evaluating the spontaneous electric polarization (SEP) of this metal has been hindered by experimental and theoretical obstacles. The experimental challenge arises from difficulties in switching polarization using an external electric field, while the theoretical limitation lies in existing methods applicable only to nonmetals. Zabalo and Stengel (Phys Rev Lett 126:127601, 2021, https://doi.org/10.1103/PhysRevLett.126.127601) addressed the experimental obstacle by proposing flexoelectricity as an alternative for practical polarization switching in LiOsO$$_3$$

3

, which requires a critical bending radius similar to BaTiO$$_3$$

3

. In this study, we focus on resolving the theoretical obstacle by modifying the Berry phase and Wannier functions approaches within density functional theory plus modern theory of polarization. By employing these modifications, we calculate the SEP of LiOsO$$_3$$

3

, comparable to the polarization of BaTiO$$_3$$

3

. We validate our predictions using various ways. This study confirms the coexistence of ferroelectricity and metallicity in this new class of ferroelectric-like metals. Moreover, by addressing the theoretical limitation and providing new insights into polarization properties, our study complements the experimental flexoelectricity proposal and opens avenues for further exploration and manipulation of polarization characteristics. The developed approaches, incorporating modified Berry phase and Wannier function techniques, offer promising opportunities for studying and designing novel materials, including bio- and nano-ferroelectric-like metals. This study contributes to the advancement of ferroelectricity in metals and provides a foundation for future research in this exciting field.
Comprehensive allostatic load risk index is associated with increased frontal and left parietal white matter hyperintensities in mid-life cognitively healthy adults
Authors: Buller-Peralta Ingrid , Gregory Sarah , Low Audrey , Dounavi Maria-Eleni , Bridgeman Katie , Ntailianis Georgios , Lawlor Brian , Naci Lorina , Koychev Ivan , Malhotra Paresh , O’Brien John T. , Ritchie Craig W. , Muniz-Terrera Graciela 
Published: January 2024

AbstractTo date, there is a considerable heterogeneity of methods to score Allostatic Load (AL). Here we propose a comprehensive algorithm (ALCS) that integrates commonly used approaches to generate AL risk categories and assess associations to brain structure deterioration. In a cohort of cognitively normal mid-life adults (n = 620, age 51.3 ± 5.48 years), we developed a comprehensive composite for AL scoring incorporating gender and age differences, high quartile approach, clinical reference values, and current medications, to then generate AL risk categories. Compared to the empirical approach (ALES), ALCS showed better model fit criteria and a strong association with age and sex. ALSC categories were regressed against brain and white matter hyperintensity (WMH) volumes. Higher AL risk categories were associated with increased total, periventricular, frontal, and left parietal WMH volumes, also showing better fit compared to ALES. When cardiovascular biomarkers were removed from the ALSC algorithm, only left-frontal WMHV remained associated with AL, revealing a strong vascular burden influencing the index. Our results agree with previous evidence and suggest that sustained stress exposure enhances brain deterioration in mid-life adults. Showing better fit than ALES, our comprehensive algorithm can provide a more accurate AL estimation to explore how stress exposure enhances age-related health decline.
Inter-study reproducibility of cardiovascular magnetic resonance-derived hemodynamic force assessments
Authors: Lange Torben , Backhaus Sören J. , Schulz Alexander , Evertz Ruben , Schneider Patrick , Kowallick Johannes T. , Hasenfuß Gerd , Kelle Sebastian , Schuster Andreas 
Published: January 2024

AbstractCardiovascular magnetic resonance (CMR)-derived hemodynamic force (HDF) analyses have been introduced recently enabling more in-depth cardiac function evaluation. Inter-study reproducibility is important for a widespread clinical use but has not been quantified for this novel CMR post-processing tool yet. Serial CMR imaging was performed in 11 healthy participants in a median interval of 63 days (range 49–87). HDF assessment included left ventricular (LV) longitudinal, systolic peak and impulse, systolic/diastolic transition, diastolic deceleration as well as atrial thrust acceleration forces. Inter-study reproducibility and study sample sizes required to demonstrate 10%, 15% or 20% relative changes of HDF measurements were calculated. In addition, intra- and inter-observer analyses were performed. Intra- and inter-observer reproducibility was excellent for all HDF parameters according to intraclass correlation coefficient (ICC) values (> 0.80 for all). Inter-study reproducibility of all HDF parameters was excellent (ICC ≥ 0.80 for all) with systolic parameters showing lower coeffients of variation (CoV) than diastolic measurements (CoV 15.2% for systolic impulse vs. CoV 30.9% for atrial thrust). Calculated sample sizes to detect relative changes ranged from n = 12 for the detection of a 20% relative change in systolic impulse to n = 200 for the detection of 10% relative change in atrial thrust. Overall inter-study reproducibility of CMR-derived HDF assessments was sufficient with systolic HDF measurements showing lower inter-study variation than diastolic HDF analyses.
Automatic muscle impedance and nerve analyzer (AMINA) as a novel approach for classifying bioimpedance signals in intraoperative pelvic neuromonitoring
Authors: Schuler Ramona , Langer Andreas , Marquardt Christoph , Kalev Georgi , Meisinger Maximilian , Bandura Julia , Schiedeck Thomas , Goos Matthias , Vette Albert , Konschake Marko 
Published: January 2024

AbstractFrequent complications arising from low anterior resections include urinary and fecal incontinence, as well as sexual disorders, which are commonly associated with damage to the pelvic autonomic nerves during surgery. To assist the surgeon in preserving pelvic autonomic nerves, a novel approach for intraoperative pelvic neuromonitoring was investigated that is based on impedance measurements of the innervated organs. The objective of this work was to develop an algorithm called AMINA to classify the bioimpedance signals, with the goal of facilitating signal interpretation for the surgeon. Thirty patients included in a clinical investigation underwent nerve-preserving robotic rectal surgery using intraoperative pelvic neuromonitoring. Contraction of the urinary bladder and/or rectum, triggered by direct stimulation of the innervating nerves, resulted in a change in tissue impedance signal, allowing the nerves to be identified and preserved. Impedance signal characteristics in the time domain and the time–frequency domain were calculated and classified to develop the AMINA. Stimulation-induced positive impedance changes were statistically significantly different from negative stimulation responses by the percent amplitude of impedance change Amax in the time domain. Positive impedance changes and artifacts were distinguished by classifying wavelet scales resulting from peak detection in the continuous wavelet transform scalogram, which allowed implementation of a decision tree underlying the AMINA. The sensitivity of the software-based signal evaluation by the AMINA was 96.3%, whereas its specificity was 91.2%. This approach streamlines and automates the interpretation of impedance signals during intraoperative pelvic neuromonitoring.
Screening herbal extracts as biostimulant to increase germination, plant growth and secondary metabolite production in wheatgrass
Authors: Yadav Anjali , Singh Shachi , Yadav Vidushi 
Published: January 2024

AbstractRecently it has been recognized that herbal plants contain endogenous molecules with biostimulant properties, capable of inducing morphological and biochemical changes in crop plants. Therefore, the present experiment was conducted to screen herbal samples for their plant growth promoting properties. Twenty-five herbal extracts were tested for their biostimulating activity on wheat crop (Triticum aestivum) through seed priming. Morphological parameters chosen for evaluation include: percent seed germination, length and weight of seedling, wheat grass length and biomass. Biochemical parameters include: total phenolic and flavonoid, enzymatic activity of catalase and phenylalanine ammonium lyase and antioxidant activity. Results indicated an increase in the tested parameters by the extracts, however the biostimulant property varied between the selected herbal samples. Some of the samples, such as Phyllanthus emblica, Plumbago zeylanica, Catharanthus roseus and Baccopa monnieri, were highly effective in inducing plant growth promoting parameters. Principal component analysis was performed and herbal samples were grouped into categories based on their activity.
Visual effects on tactile texture perception
Authors: Roberts Roberta D. , Li Min , Allen Harriet A. 
Published: January 2024

AbstractHow does vision affect active touch in judgments of surface roughness? We contrasted direct (combination of visual with tactile sensory information) and indirect (vision alters the processes of active touch) effects of vision on touch. Participants judged which of 2 surfaces was rougher using their index finger to make static contact with gratings of spatial period 1580 and 1620 μm. Simultaneously, they viewed the stimulus under one of five visual conditions: No vision, Filtered vision + touch, Veridical vision + touch (where vision alone yielded roughness discrimination at chance), Congruent vision + touch, Incongruent vision + touch. Results from 32 participants showed roughness discrimination for touch with vision was better than touch alone. The visual benefit for touch was strongest in a filtered (spatially non-informative) vision condition, thus results are interpreted in terms of indirect integration. An indirect effect of vision was further indicated by a finding of visual benefit in some but not all visuo-tactile congruency conditions.
Melatonin enhances captopril mediated cardioprotective effects and improves mitochondrial dynamics in male Wistar rats with chronic heart failure
Authors: El-Sayed Sherein F. , Abdelhamid Amira Mohamed , ZeinElabdeen Shimaa Gamal , El-wafaey Dalia Ibrahim , Moursi Suzan M. M. 
Published: January 2024

AbstractMitochondrial dysfunction is a recent emerging research scope that proved to be involved in many cardiovascular diseases culminating in chronic heart failure (CHF), which remains one of the primary causes of morbidity and mortality. This study investigated the added cardio-protective effects of exogenous melatonin administration to conventional captopril therapy in isoproterenol (ISO) exposed rats with CHF. Five groups of Wistar rats were recruited; (I): Control group, (II): (ISO group), (III): (ISO + captopril group), (IV): (ISO + melatonin group) and (V): (ISO + melatonin/captopril group). Cardiac function parameters and some oxidant, inflammatory and fibrotic markers were investigated. Moreover; mRNA expression of mitochondrial mitophagy [parkin & PTEN induced kinase 1 (PINK1)], biogenesis [Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α)], fusion [mitofusin 2 (Mfn2)] and fission [dynamin-related protein 1 (DRP-1)] parameters in rat’s myocardium were evaluated. Rats’ myocardium was histo-pathologically and immunohistochemically evaluated for Beclin1 and Sirt3 expression. The present study revealed that captopril and melatonin ameliorated cardiac injury, oxidative stress biomarkers, and pro-inflammatory cytokines in ISO-exposed rats. These protective effects could be attributed to mitochondrial dynamic proteins control (i.e. enhanced the mRNA expression of parkin, PINK1, PGC-1α and Mfn2, while reduced DRP-1 mRNA expression). Also, Beclin1 and Sirt3 cardiac immunoreactivity were improved. Combined captopril and melatonin therapy showed a better response than either agent alone. Melatonin enhanced myocardial mitochondrial dynamics and Sirt3 expression in CHF rats and may represent a promising upcoming therapy added to conventional heart failure treatment.