bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partners' health and silver splits in Europe: A gendered pattern?
Authors: Vignoli Daniele , Alderotti Giammarco , Tomassini Cecilia 
Published: February 2025

AbstractObjectiveBuilding on the Theory of Dyadic Illness Management, this paper addresses the correlates of silver splits—voluntary union dissolutions after age 50—among mixed‐gender couples in Europe focusing on the role of partners' health status.BackgroundFamily diversity at older ages is growing in wealthy countries, with late union dissolutions increasingly occurring through separation and divorce rather than widowhood. Nonetheless, the correlates of silver splits in Europe, particularly regarding health within couples, remain underexplored.MethodWe utilized data from the European Survey of Health, Ageing, and Retirement (SHARE), spanning Waves 1 (2004–2005) to 9 (2021–2022), and employed discrete‐time event‐history analysis to model the risk of silver splits, separately among couples aged 50–64 and 65+ (N = 31,915 and 48,361 couple‐years, respectively). We inspected three health dimensions: self‐rated health, Global Activity Limitations Index, depression.ResultsWe found a non‐negligible and gendered association between health and union dissolution among couples aged 50–64. Couples in which the woman reported poor self‐rated health or faced severe activity limitations, whereas the man maintained good health, exhibited a higher risk of silver splits compared to couples in good health. Conversely, the risk of silver splits did not change significantly when the man experienced poor self‐rated health or activity limitations compared to couples in good health. Results among older couples suggested that the health/silver split link weakens with age.ConclusionGendered health‐related selection effects appear among older European couples, as men struggle more than women with a partner's declining health, potentially jeopardizing the couple's stability.
Impact of COVID‐19 on Hospital Admissions for Children With Developmental Disadvantages: A Western Sydney Metropolitan Hospital Experience on Health Inequity
Authors: Li Lanxin , Bhurawala Habib , Liu Anthony 
Published: February 2025

ABSTRACTAimsTo investigate the impact of Sydney's COVID‐19 lockdown on children with developmental disadvantages and reflect on current clinical practice.MethodsRetrospective data was collected from a western Sydney metropolitan hospital's electronic database and patients. We reviewed all children with Autism Spectrum Disorder (ASD), Cerebral Palsy (CP) or Intellectual Disability (ID) admitted 36 months prior to and after lockdown policy being implemented.ResultsThe prevalence of hospital presentation was reduced during the lockdown period. The average length of stay (LoS) increased by approximately 1.5 folds. Comparatively, the average LoS of the general paediatric population increased minimally. Seizures, asthma, and upper respiratory tract infections were the three commonest issues for hospital admissions in both periods. COVID‐19 infection accounted for 4% of admissions in the lockdown period. Around 20.8% of patients with disadvantages were admitted with more than two major issues. None of these patients had concurrent COVID‐19 infection.ConclusionsChildren with developmental disabilities experience greater disadvantages during lockdown. The likely reasons include inequity caused by increased barriers to healthcare service. The indirect benefit of reducing infection transmission during lockdown was not reflected in our patient group, contributing to the disease burden. Chronic diseases remain the most common causes of admissions in all periods, suggesting the essentiality of improving chronic disease management in future clinical practice.
A Novel HLA‐B*08:331 Allele Identified by Next‐Generation Sequencing
Authors: Rakhmanov Mirzokhid , Bernheiden Martin , Verboom Murielle , Hallensleben Michael , Emmerich Florian 
Published: February 2025

ABSTRACTHLA‐B*08:331 differs from HLA‐B*08:01:01:01 by a single nucleotide substitution in codon ‐3 in exon 1.
A Framework for Exploring “Transfer‐Out” Land Parcels for Urban Development Under the Ecological Control Line (ECL) Policy in China
Authors: Zhai Yaqian , Pan Yongting , Guan Qingfeng , Yao Yao , Liang Xun 
Published: February 2025

ABSTRACTHow to explore land spaces for future urban expansion under the ECL policy in China has been an essential issue. Previous methods or models just consider the land parcel's current land‐use condition, while ignoring its future urbanization trend. This study proposes a framework for identifying the suitable “transfer‐out” land parcels within the ECL by integrating the future urbanization probability and ecosystem services value. First, a vector‐based cellular automata is adopted to determine urbanization probabilities of land parcels, and the ecosystem services values are evaluated based on the calculated equivalent table. Then, a “two‐way screening” method is proposed to identify “transfer‐out” land parcels by prioritizing the minimization of ecological value losses and the maximization of urban development benefits. The identified land parcels are evaluated at the suitability level by parcel connectivity analysis. The proposed framework was applied in Shenzhen, China. The results indicated that several “transfer‐out” land clusters more suitable for planning as residential or public‐service lands. This framework can provide global city planners with valuable policy guidance for dealing with similar ecological pressures.
On Torelli groups and Dehn twists of smooth 4‐manifolds
Authors: Krannich Manuel , Kupers Alexander 
Published: February 2025

AbstractThis note has two related but independent parts. Firstly, we prove a generalisation of a recent result of Gay on the smooth mapping class group of . Secondly, we give an alternative proof of a consequence of work of Saeki, namely that the Dehn twist along the boundary sphere of a simply connected closed smooth 4‐manifold with is trivial after taking connected sums with enough copies of .
Harmonic Oscillator, Dissipation, and Thermodynamics
Authors: Carcaterra Antonio , Akay Adnan 
Published: February 2025

Abstract
A loss-free harmonic oscillator when treated as the working substance in a cylinder with a piston exhibits dissipation characterized by hysteresis cycles. Dissipation in this case develops through conversion of potential energy of the springs and part of the work by piston motion to kinetic energy of the oscillator that represents its temperature. The results also yield analogies with several complex thermodynamic notions such as lost work, heating and cooling, Joule–Thompson expansion and temperature inversion, and regimes of maximum power and maximum efficiency as in finite thermodynamic systems. Use of multiple oscillators with different frequency distributions supports the notion of a dissipative constitutive relationship emerging from a dissipation-free model in which the stress depends on both strain and strain rates as in heuristic models used in solid mechanics as, for example, the Johnson-Cook model.
Class B scavenger receptor resists WSSV replication by recognizing the viral lipid molecule and promoting phagocytosis
Authors: Huang Yi-Heng , Guo Xin-Lu , Shan Meng-Ke , Yang Gui-Wen , Yang Hui-Ting 
Published: February 2025

ABSTRACT

Class B scavenger receptors (SRBs) have been well-studied in bacteria-induced immune responses in invertebrates. However, the status of SRB-defending viruses remains unclear. In this study, we identified a scavenger receptor in
Procambarus clarkii
(crayfish), which is homologous to mammalian SRBs, and designated it as
Pc
SRB. The expression of
Pc
SRB was upregulated after the WSSV challenge. The survival rate of crayfish was decreased, but the WSSV copy number increased after
Pc
SRB knockdown during virus invasion. In addition,
Pc
SRB bound to WSSV. Furthermore, we detected how
Pc
SRB interacted with WSSV, and we found that
Pc
SRB could bind to cholesta-3,5-diene, (CD3,5), a novel WSSV lipid ligand, rather than dibutyl phthalate (DBP). Besides,
Pc
SRB could bind to VP19, VP26, and VP28, rather than VP24. Mutant-binding experiments demonstrated that the hydrophobic domain (130–180 aa) of
Pc
SRB is important for recognizing WSSV. Furthermore,
Pc
SRB might promote lysosomal eliminating function to degrade WSSV. Altogether, we identified a new mechanism for scavenger receptor recognition and resistance to WSSV.

IMPORTANCE

Pc
SRB could bind to WSSV directly.
Pc
SRB could interact with WSSV via binding to lipid molecule CD3,5 and viral envelope proteins.
Pc
SRB could influence lysosomal activation.
A scoping review on the impact of women’s global leadership: evidence to inform health leadership
Authors: Kalbarczyk Anna , Banchoff Katherine , Perry Kelly E , Pram Nielsen Charlotte , Malhotra Anju , Morgan Rosemary 
Published: February 2025

IntroductionThe documented benefits of gender parity in leadership are emerging—women leaders have been shown to have a positive impact on maternal and health care policies, strengthen health facilities, and reduce health inequalities. More research is needed, however, to document their impact on global health. We go beyond the well-documented barriers that uphold the lack of gender parity by identifying areas where women leaders are making an impact to inform investment, programming, and policy.MethodsWe conducted a scoping review of peer-reviewed literature, following Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews (PRISMA-ScR) guidelines, to map evidence on the impact of women’s leadership in organisations in low- and middle-income countries. As many leadership outcomes are cross-disciplinary, outcomes were explored across sectors with particular attention paid to the relevance of these outcomes for global health.Results137 articles were included in the review. Studies found women leaders’ positive influence on six areas of impact: (1) financial performance, risk, and stability, (2) innovation, (3) engagement with ethical initiatives, (4) health, (5) organisational culture and climate outcomes, and (6) influence on other women’s careers and aspirations. Articles reporting mixed results focused on multiple indicators and still largely pointed to positive results, particularly when modified by other factors including increased education, increased experience, and opportunities to work with other women across the organisation. In all sectors, across leadership roles, and across geographies, women’s leadership can produce positive results. Women leaders’ success, however, cannot be separated from the contexts in which they work, and unsupportive environments can affect the extent to which women leaders can have an impact.ConclusionIncreased and sustained investment in women’s leadership within the health sector can lead to improved outcomes for organisations and their clients. Such investments must not only target individual women, but also seek to foster organisational cultures that promote and retain women leaders and support their independent decision-making.
Will things feel better in the morning? A time-of-day analysis of mental health and wellbeing from nearly 1 million observations
Authors: Bu Feifei , Bone Jessica K , Fancourt Daisy 
Published: February 2025

BackgroundMood is known to change over seasons of the year, days of the week, and even over the course of the day (diurnally). But although broader mental health and well-being also vary over months and weeks, it is unclear whether there are diurnal changes in how people experience and report their mental health.ObjectiveTo assess time-of-day association with depression, anxiety, well-being and loneliness.MethodsThe study analysed data from 49 218 adults drawn from the University College London COVID-19 Social Study, which gathered detailed repeated measurements from the same participants across time over a 2-year period (March 2020–March 2022, 18.5 observation per person). Data were analysed using linear mixed-effects models.FindingsThere is a clear time-of-day pattern in self-reported mental health and well-being, with people generally waking up feeling best and feeling worst around midnight. There is also an association with day of the week and season, with particularly strong evidence for better mental health and well-being in the summer. Time-of-day patterns are moderated by day, with more variation in mental health and individual well-being during weekends compared with weekdays. Loneliness is relatively more stable.ConclusionsGenerally, things do seem better in the morning. Hedonic and eudemonic well-being have the most variation, and social well-being is most stable.Clinical implicationsOur findings indicate the importance of considering time, day and season in research design, analyses, intervention delivery, and the planning and provision of public health services.
Factors influencing paramedic conveyance decisions when attending children with minor head injury: a qualitative study
Authors: Proctor Alyesha , Billing Jedd , Lyttle Mark , Voss Sarah , Benger Jonathan 
Published: February 2025

Introduction
Children with head injury are commonly transported to the ED by ambulance. However, most of those conveyed are deemed non-serious and are discharged at triage. Research is needed to explore the factors that influence paramedics when deciding to convey children with minor head injury to the ED, and to establish whether a clinical decision tool designed to support them would be beneficial.

Methods
A generic qualitative approach, comprising semistructured interviews with front-line ambulance paramedics working in the UK. Interviews were audio-recorded and transcribed. Data were analysed using reflexive thematic analysis. Interviews aimed to explore the factors that influence paramedics when deciding to convey children with minor head injury to the ED.

Results
A total of 20 paramedics from several ambulance services participated in interviews. Three overarching themes were identified: ‘we just take them in’; ‘there are too many hurdles’; ‘creating the right tool’. These were further categorised into subthemes. Paramedics do not feel confident when assessing and managing children with head injury, and convey children to hospital due to fear of consequences, despite knowing there will be no intervention in the ED. Further education, a prehospital paediatric clinical decision tool and greater support from Ambulance Trusts would be welcomed by paramedics. Criteria such as: parental anxiety; time; wound closure; policy and non-accidental injury need to be considered in a clinical decision tool designed to support paramedics’ management of children with head injury.

Conclusion
Paramedics generally feel a lack of confidence in assessing and managing children with head injury. A decision tool, coupled with training and useful feedback from EDs following conveyance, would be useful to help improve decision-making.
Prognostic factors of chronic postsurgical pain in children and adolescents: a systematic review and meta-analysis
Authors: Rosenbloom Brittany N , Frederiksen Simona Denise , Wang Vienna , Park Christine S , Gordon Grace , Brar Gurpreet , Rasic Nivez , Stinson Jennifer N , Birnie Kathryn A , Rabbitts Jennifer A 
Published: February 2025

BackgroundApproximately 28% of children and adolescents undergoing major surgery develop chronic postsurgical pain (CPSP; pain persisting>3 months). A previous review attempted to investigate biopsychosocial prognostic factors for pediatric CPSP; however, due to lack of data, no meta-analytic techniques were employed. Since that review, numerous studies have investigated risk/protective factors that fall within an Interpersonal Fear Avoidance Model for CPSP, thus warranting a reinvestigation of prognostic factors.ObjectiveThis systematic review and meta-analysis aimed to examine prognostic factors, measurement tools applied, and their effect on the development of CPSP.Evidence reviewProspective, observational studies examining prognostic factors of pediatric CPSP using validated self-report measures were included. 4884 unique publications were screened and 15 met inclusion criteria.FindingsThe pooled effect size for the association between presurgical child pain intensity and the presence of child CPSP was significant, OR=0.540 (95% CI=0.184 to 0.894). Child anxiety, child pain-related anxiety, and parent pain catastrophizing were not significant prognostic factors for child CPSP. Using Grading of Recommendations, Assessment, Development, and Evaluation, the certainty in prognostic estimates was moderate. Risk of bias using Quality in Prognostic Study tool ranged from low to moderate.ConclusionsPresurgical pain was the only presurgical risk factor at the meta-analytic level that significantly predicted pediatric CPSP, highlighting the importance of prioritizing pain management throughout the perioperative experience, starting before surgery. Depressive symptoms and sleep disturbance were the two potential risk/protective factors that were unable to be assessed due to insufficient data or use of an unvalidated measure indicating a critical need for future research.PROSPERO registration numberCRD42022306340.
Topological defects in f(T) theory of gravity
Authors: Hatkar S. P. , Tadas D. P. , Katore S. D. 
Published: February 2025

Abstract
In this paper, we investigate the behaviour of domain walls and one-dimensional cosmic string with locally rotationally symmetric (LRS) Bianchi type-I metric in the context of f(T) gravity. Three different types of deceleration parameter (DP) forms, such as (i)

$$q=-kt+l-1$$

q
=
-
k
t
+
l
-
1

, (ii)

$$q=b(t)$$

q
=
b
(
t
)

, and (iii)

$$q=-1+\frac{\gamma }{1+a^\gamma }$$

q
=
-
1
+

γ

1
+

a
γ

, are used to determine the exact solution of the field equation. We observe the profound effect of the torsion scalar T on physical parameters. Also, the universe was dominated by string at an early stage of evaluation.
Kinome Reprogramming of G2/M Kinases and Repression of MYCN Contribute to Superior Efficacy of Lorlatinib in ALK-Driven Neuroblastoma
Authors: Matkar Smita , East Michael P. , Stuhlmiller Timothy J. , Witek Gabriela M. , Farrel Alvin , Pastor Steven , Okumu Denis O. , Kennedy Anne , Kalna Joshua R. , Berko Esther R. , Casey Colleen E. , Krytska Kateryna , Patel Khushbu , Rokita Jo Lynne , Gerelus Mark , Maris John M. , Johnson Gary L. , Mossé Yael P. 
Published: February 2025

Abstract
Mutations in the tyrosine kinase domain of the anaplastic lymphoma kinase (ALK) oncogene in neuroblastoma occur most frequently at one of three hotspot amino acid residues, with the F1174* and F1245* variants conferring de novo resistance to first- and second-generation ALK inhibitors, including crizotinib and ceritinib. Lorlatinib, a third-generation ALK/ROS1 inhibitor, overcomes de novo resistance and induces complete and sustained tumor regressions in patient-derived xenograft models unresponsive to crizotinib. Lorlatinib has now completed phase 1 testing in children and adults with relapsed/refractory ALK-driven neuroblastoma and entered pivotal phase 3 testing within the Children’s Oncology Group. To define mechanisms underlying the superior activity of lorlatinib, we utilized a chemical proteomics approach to quantitatively measure functional kinome dynamics in response to lorlatinib and crizotinib in clinically relevant ALK-driven neuroblastoma patient-derived xenograft models. Lorlatinib was a markedly more potent inhibitor of ALK and preferentially downregulated several kinases implicated in G2/M cell-cycle transition compared with crizotinib. Lorlatinib treatment also led to the repression of MYCN expression and its occupancy at promoters of the same G2/M kinases. These data provide mechanistic insight into the superior efficacy of lorlatinib over crizotinib for the treatment of ALK-driven neuroblastoma.
ATAD2 Drives Prostate Cancer Progression to Metastasis
Authors: Dutta Anindita , Rodriguez-Calero Antonio , Ronaldson-Bouchard Kacey , Offermann Anne , Rahman Daoud , Vhatkar Twinkle Bapuji , Hasson Dan , Alshalalfa Mohammed , Davicioni Elai , Karnes R. Jeffrey , Rubin Mark A. , Vunjak-Novakovic Gordana , Abate-Shen Cory , Arriaga Juan Martin 
Published: February 2025

Abstract
Metastasis accounts for the overwhelming majority of cancer deaths. In prostate cancer and many other solid tumors, progression to metastasis is associated with drastically reduced survival outcomes, yet the mechanisms behind this progression remain largely unknown. ATPase family AAA domain containing 2 (ATAD2) is an epigenetic reader of acetylated histones that is overexpressed in multiple cancer types and usually associated with poor patient outcomes. However, the functional role of ATAD2 in cancer progression and metastasis has been relatively understudied. Here, we employ genetically engineered mouse models of prostate cancer bone metastasis, as well as multiple independent human cohorts, to show that ATAD2 is highly enriched in bone metastasis compared with primary tumors and significantly associated with the development of metastasis. We show that ATAD2 expression is associated with MYC pathway activation in patient datasets and that, at least in a subset of tumors, MYC and ATAD2 can regulate each other’s expression. Using functional studies on mouse bone metastatic cell lines and innovative organ-on-a-chip bone invasion assays, we establish a functional role for ATAD2 inhibition in reducing prostate cancer metastasis and growth in bone.
Implications: Our study highlights ATAD2 as a driver of prostate cancer progression and metastasis and suggests it may constitute a promising novel therapeutic target.
Human Papillomavirus Type 16 E6 Seroprevalence among Men Living with HIV without HPV-Driven Malignancies
Authors: Duff Ashley J. , Otieno Christopher O. , Chen Li , Mannion Kyle , Topf Michael C. , Michels Birgitta E. , Butt Julia , Woodward Beverly O. , Lima Morgan C. , Erdem Husamettin , Leonard Michael A. , Turner Megan M. , Waterboer Tim , Sudenga Staci L. , Lang Kuhs Krystle A. 
Published: February 2025

Abstract
Individuals living with human immunodeficiency virus (HIV) are at a higher risk for developing human papillomavirus–driven oropharyngeal squamous cell carcinoma (HPV + OPSCC). There are no methods for early detection; however, HPV16 E6 antibodies have been identified as a promising early marker. The objective of this study was to evaluate the prevalence of HPV16 E6 antibodies among men living with HIV, with secondary objectives of analyzing clinical and serologic predictors of HPV16 E6 seropositivity. Banked blood specimens from 2,320 men ages ≥40 years living with HIV in Tennessee were evaluated for the following HPV16 antibodies: L1, E1, E2, E4, E6, and E7. HPV16 E6 antibody levels were further categorized as moderate or high. Demographic, clinical, and serologic determinants of HPV16 E6 seropositivity were evaluated using logistic regression. HPV16 L1 antibodies were most common (22.8%), followed by E4 (10.5%), E6 (5.6%), E2 (4.8%), and E7 (4.0%). Of the 130 HPV16 E6 seropositives, 55 (2.4%) had moderate and 75 (3.2%) had high seropositivity. HPV16 E6 seropositive men had nearly twofold greater odds of seropositivity against one additional HPV16 E antigen [OR: 1.67 (95% CI, 1.10–2.52); P = 0.015] and more than threefold greater odds of seroreactivity against two additional HPV16 E antigens [OR: 3.21 (95% CI, 1.40–7.33); P = 0.006]. HPV16 E6 seropositivity was not associated with the clinical or demographic factors evaluated. In the largest study to date, HPV16 E6 seroprevalence was elevated compared with prior studies in HIV populations (range: 1.1%–3.2%) and likely reflects the high incidence of HPV + OPSCC in the Southeast region of the United States.
Prevention Relevance: Our findings fill an important gap, given that our study is the largest to date to evaluate HPV antibodies among men living with HIV and is the first study to do so in the Southeastern United States, the region with the highest prevalence of both HIV and HPV + OPSCC in the nation.