bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turkish Translation and Psychometric Properties of the Peabody Developmental Motor Scale-2 in 0–24 Months Turkish At-Risk Infants
Authors: Yucekaya Bircan , Comuk Balci Nilay , Kemer Seda Nur , Gercek Hasan , Unuvar Bayram Sonmez , Demirsoz Mert 
Published: February 2025

This study was designed to investigate the construct–concurrent validity and reliability of the Turkish version of the Peabody Developmental Motor Scale–2 (PDMS-2) in at-risk infants between 0–24 age in Turkey. In this study, 120 infants (70 males, 50 females) participated in the study (mean corrected age 20.18 ± 22.535 weeks). The PDMS-2 scale consists of two subdimensions, the Fine Motor Quotient (FMQ) and the Gross Motor Quotient (GMQ). Whereas the construct validity was assessed using confirmatory factor analysis, concurrent validity was investigated using the correlation between PDMS-2 and the Alberta Infant Motor Scale and the Hammersmith Infant Neurological Examination with Spearman’s correlation analysis. The PDMS-2 was applied twice for test–retest reliability. Cronbach’s alpha (α) and the intraclass correlation coefficient (ICC) were used for reliability. ICC value was with 95% CI. The overall reliability coefficient of the test was found to be Croncbach’s α = 0.865. TICC values were found (ICC FMQ: 0.998, ICC GMQ: 0.998). Construct validity ([Formula: see text]/SD = 4.396; root mean square error of approximation = 0.021; goodness-of-fit index = 0.951) and concurrent validity ( r = 0.502–0.771; p < .05) were confirmed as acceptable. The PDMS-2 demonstrated good psychometric properties and can be used as a reliable and valid measure to assess neurodevelopmental aspects of Turkish at-risk infants.
The effect of camera side on the VOR gain in video head impulse test
Authors: Xu Mingwei , Zhang Qin , Wu Qiong , Yao Yuan , Gong Tianyu , Yang Jun , Jin Yulian , Fan Mengyun , Lopez-Escamez Jose A , Zhang Qing 
Published: February 2025

Objective This study aims to investigate the effect of camera positioning (left-sided vs right-sided) on the vestibulo-ocular reflex (VOR) gain values of normal subjects during the video head impulse test (vHIT), thereby providing valuable reference data for otology clinical practice. Methods Thirty healthy adults (60 ears) were recruited and examined by vHIT for the three pairs of semicircular canals (SCs). During the examination, we meticulously recorded and compared the VOR gain values in the six canal planes—right lateral (RL), left lateral (LL), right anterior-left posterior (RALP), and left anterior-right posterior (LARP)—with the camera positioned on the left side first, followed by repositioning on the right side. We evaluated instantaneous gain (40 ms, 60 ms, and 80 ms), 0–100 ms median gain, and regression gain in 0–100 ms for all SCs. Results For horizontal canals, higher VOR gain values were recorded when the camera was positioned on the same side as the canal being tested. The gain value in LARP was higher when the camera was on the left side than on the right side, while the gain value in RALP was higher when the camera was on the right side than on the left side. Conclusion This study underscores the importance of camera positioning on VOR gain values for both lateral and vertical canals during vHIT. To mitigate the effects of these variables, standardization of operational procedures and equipment settings is crucial.
A higher vertebrobasilar pulsatility index is associated with lower parietal perfusion in Alzheimer's disease
Authors: Lin Shu-Wen , Hsu Yen-Hsuan , Yang Jir-Jei , Tu Min-Chien 
Published: February 2025

Background While cerebrovascular hemodynamics exhibits critical interplay with the pathogenesis of dementia, limited articles have examined the impact of vertebrobasilar (VB) hemodynamics on cerebral blood flow (CBF), and to what extent it varies by dementia subtypes. Objective To explore the associations between VB hemodynamics and CBF by dementia subtypes. Methods This research recruited a total of 120 dementia patients [43 subcortical ischemic vascular dementia (SIVD); 59 Alzheimer's disease (AD); 18 mixed dementia] and 40 older adults with normal cognition and compared their transcranial doppler (TCD) flow parameters and arterial spin labeling-measured CBF. Using the partial correlation analysis, the associations between TCD parameters and CBF values were explored among the defined subgroups. Results A higher VB pulsatility index (PI) was related to lower parietal CBF and lower VB end-diastolic velocity (EDV). Moreover, the significance of flow parameters in the basilar artery (BA) to parietal CBF was identified: peak-systolic velocity (PSV) unanimously showed positive correlations among all subgroups except SIVD, and both PSV and EDV showed positive correlations in AD. Of note, there were more noticeable “BA flow-frontoparietal CBF” associations among the high than low VB PI group, and AD than SIVD group. Conclusions The findings indicate that VB-resistance-related parietal vulnerability and topological CBF associations vary by dementia subtypes. Given VB hemodynamics-CBF relationships, the current research extends our understanding of the vasocognopathic effects among dementia patients.
Feline eosinophilic sclerosing fibroplasia of the duodenum treated with gastrojejunostomy in a domestic shorthair cat
Authors: Blew Jordyn E , Bradley Charles W , Holt David E 
Published: February 2025

Case summary A 2-year-old female spayed domestic shorthair cat was presented for evaluation of severe thickening of the proximal duodenum identified on abdominal ultrasound after a 1-year history of vomiting. At surgery, a proximal duodenal mass encompassed the areas of the major and minor duodenal papillae. A gastrojejunostomy was performed to bypass the proximal duodenum and maintain the integrity of the major duodenal papilla. Histopathology revealed changes consistent with feline eosinophilic sclerosing fibroplasia. The cat was treated with prednisolone and survived for 2.5 years. It was euthanized for bronchopneumonia. Relevance and novel information This case report describes a surgical approach for cats with lesions involving the pylorus and proximal duodenum. Gastrojejunostomy provided a therapeutic option that preserved exocrine pancreatic and biliary secretion in this cat.
Healthcare Professionals’ Decision-Making Regarding Lumbar Fusion Surgery or Conservative Care for Adults With Severe, Persistent Low Back Pain: An Australian Cross-Sectional Survey Using Case Vignettes
Authors: Window Peter , Bada Eniola , Stovell Matthew G , Ahuja Sashin , Beard David J , Gardner Adrian , Foster Nadine E 
Published: February 2025

Study Design Cross-sectional Survey. Objectives The objective of this study was to describe clinicians’ decision-making regarding suitability of patient cases for lumbar fusion surgery or conservative care and the level of equipoise to randomise participants into a randomised controlled trial (RCT). Methods An online survey distributed via Australian professional networks to clinicians involved in low back pain care, collected data on clinical discipline, clinical experience, practice setting and preferred care of five patient case vignettes (ranging in age, pain duration, BMI, imaging findings, neurological signs/symptoms). Clinicians were asked about preferred clinical care and willingness to randomise each case. Results Of 101 respondents (31 orthopaedic surgeons, 17 neurosurgeons, 50 allied health professionals (AHPs), 1 pain physician, 1 nurse), 44% worked in public health services only, 36.4% in both public and private, 19.2% in private only. 46.5% had over 20 years clinical experience. Conservative care was preferred for all cases (83.1%–90.9%). Surgeons preferred an anterior approach to lumbar fusion (range 40.6%–68.4%). On average 51.9% (range: 47%–55%) indicated willingness to randomise cases, with orthopaedic (61.5%) and neurosurgeons (64.9%) more willing than AHPs (44.4%). Willingness to randomise was highest in younger cases with shorter pain duration, no neurological symptoms/signs and localised degeneration, and lowest when cases had high BMI, longer pain duration, and inadequate conservative management. Willingness to randomise was higher in those in private (70.3%) vs public health care services (43.6%). Conclusions Over half of respondents reported willingness to randomise cases, indicating sufficient clinical equipoise for a future RCT.
A Complex Adaptive Systems Approach to Health Professions Education Transformation: The Case of the University of Missouri-Columbia School of Medicine and an Integrated Quality Improvement-Interprofessional Collaborative Practice Curriculum
Authors: Stevenson Katherine , D’Eon Marcel , Headrick Linda , Gäre Boel Andersson 
Published: February 2025

OBJECTIVES In 2003, the University of Missouri-Columbia School of Medicine (MU SOM) initiated an integrated quality improvement-interprofessional collaborative practice (QI-ICP) curriculum as part of a larger curriculum renewal process. While exploring a different case study focused on the content of the curriculum, investigators became intrigued by MU SOM's approach to change, specifically, how complex adaptive systems (CAS) thinking may have supported sustained transformational change in curriculum across multiple health professions programs. The primary aim of this study was to elucidate the aspects of MU's experience with transformation that were grounded in CAS. A secondary aim was to explore the usefulness of a CAS-based management framework for organizational transformation using the case of curricular transformation in health professions education at MU. METHODS Data collection involved interviews, with twelve faculty from a variety of programs, and document analysis, including previously published papers and gray literature (websites, organizational charts and planning documents, and faculty development materials). RESULTS Using abductive analysis, we found that leadership in the health professions programs at MU, informed by earlier learning about organizational sensemaking and CAS theory, addressed all 9 of the characteristics of CAS presented in the initial framework. Additionally, systematic combining revealed the need to adjust the framework to ensure applicability to health professions education. The analysis of MU's experience also offered key insights into how that transformation happened in practice. The CAS framework adjustments make explicit the importance of common purpose and the concept of leadership as an emergent event and make it easier to apply the framework to a broader set of organizational contexts, including health professions education. CONCLUSION The use of the adjusted framework, informed by insights from this specific case, may help health professions education programs evaluate past change efforts or plan for future change.
A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner
Authors: Ding Xin-Yu , Zhang Hua-Ying , Chen Jia-Hao , Yang Meng-Jie , Huang Zhi-Xiong , Lei Yi-Hong , Sun Qin-Kun , Bai Jian-Bin , Lin Dian-Chao , Lan Jian-Fa , Ren Lu-Lu , Chen Zheng-Yi , Zhou Wei-Dong , Chen Qiong-Hua 
Published: February 2025

Abstract

Background
Endometriosis (EMs) is a condition characterized by the growth of endometrial tissue outside the uterine cavity. Although this condition is benign, it has cancer-like features. N6-methyladenosine (m6A) is a common RNA modification involved in diverse biological processes, but its role in EMs remains unclear.

Methods
A human endometrial stromal cell line (HESCs), primary eutopic endometrial stromal cells (Eu-ESCs), primary ectopic endometrial stromal cells (Ec-ESCs), and clinical samples were used in this study. A colorimetric assay was used to measure methylation levels in clinical and mouse EMs samples. Functional assays (CCK-8, EdU, Transwell, and wound healing) were used to evaluate phenotypic changes. m6A immunoprecipitation sequencing (MeRIP-seq) identified downstream targets. Mechanistic studies were conducted via qRT‒PCR, Western blot, RNA immunoprecipitation (RIP), dual-luciferase reporter, and RNA stability assays.

Results
We detected aberrantly low levels of m6A within endometriotic lesions, which was attributed to increased expression of the m6A eraser fat mass and obesity-associated protein (FTO). Notably, estrogen and inflammatory factors, which are recognized as pathogenic agents in EMs amplify FTO expression while suppressing m6A levels. In vitro experiments demonstrated that overexpression of FTO in endometrial stromal cells leads to a reduction in m6A levels and concomitantly promotes their proliferation, migration, and invasion. Furthermore, both genetic deletion of Fto and chemical inhibition of FTO impeded the growth of ectopic endometrial lesions in vivo. By utilizing m6A-seq, we identified GEF-H1 (a Rho guanine nucleotide exchange factor) as a pivotal downstream target of FTO. Specifically, diminished m6A methylation at a certain site within the 3'UTR of GEF-H1 promotes its expression in a YTH N6-methyladenosine RNA-binding protein F1 (YTHDF1)-dependent manner, thereby activating the RhoA pathway. Subsequent experiments revealed that GEF-H1 mediates the effects of FTO in promoting migration and invasion.

Conclusions
This study revealed that FTO decreases the m6A level of GEF-H1, thereby increasing its stability, which in turn activates the GEF-H1-RhoA pathway to promote the migration and invasion of endometrial stromal cells, thereby inducing EMs. Our findings suggest potential therapeutic avenues for targeting FTO to alleviate EMs progression.
Neural Network Adaptive Hierarchical Sliding Mode Control for the Trajectory Tracking of a Tendon-Driven Manipulator
Authors: Zhang Yudong , He Leiying , Chen Jianneng , Yan Bo , Wu Chuanyu 
Published: February 2025

Abstract
Tracking control of tendon-driven manipulators has become a prevalent research area. However, the existence of flexible elastic tendons generates substantial residual vibrations, resulting in difficulties for trajectory tracking control of the manipulator. This paper proposes the radial basis function neural network adaptive hierarchical sliding mode control (RBFNNA-HSMC) method, which combines the dynamic model of the elastic tendon-driven manipulator (ETDM) with radial basis neural network adaptive control and hierarchical sliding mode control technology. The aim is to achieve trajectory tracking control of ETDM even under conditions of model inaccuracy and disturbance. The Lyapunov stability theory demonstrates the stability of the proposed RBFNNA-HSM controller. In order to assess the effectiveness and adaptability of the proposed control method, simulations and experiments were performed on a two-DOF ETDM. The RBFNNA-HSM method shows superior tracking accuracy compared to traditional model-based HSM control. The experiment shows that the maximum tracking error for ETDM double-joint trajectory tracking is below 2.593×10-3 rad and 1.624×10-3 rad, respectively.
Recurrent orbital inflammatory syndrome as a presenting sign of multiple myeloma: a case report
Authors: Depraetere Chloe , De Vriendt Ciel , Roels Dimitri , Kreps Elke O. , Ninclaus Virginie G. S. 
Published: February 2025

Abstract

Introduction
Orbital inflammation has a variety of underlying causes and warrants comprehensive work-up including extensive blood work and imaging studies. This case report highlights a rare presentation of multiple myeloma presenting as recurrent orbital inflammatory syndrome.

Case Report
A 61-year-old woman experienced brief episodes of recurrent orbital inflammation, as documented by MRI. Work-up revealed a high-risk smoldering myeloma without sufficient evidence of plasma cell-mediated orbital inflammation on the first biopsy samples. The CRAB criteria (hyperCalcemia, Renal insufficiency, Anemia, Bone lesions) were not met, nor were there formal criteria for myeloma. The appearance of crystalline keratopathy allowed for a diagnosis of multiple myeloma, as this ocular involvement demonstrated organ damage. Myeloma treatment led to a complete and ocular remission.

Discussion
This case emphasizes the importance of conducting a thorough systemic work-up and the need for repeated comprehensive ophthalmologic evaluations with each flare-up of recurrent orbital inflammation. Subtle but rare changes observed during follow-up can provide critical information that may alter the diagnosis.
The oldest continuous association between astigmatid mites and termites preserved in Cretaceous amber reveals the evolutionary significance of phoresy
Authors: Sendi Hemen , Klimov Pavel B. , Kolesnikov Vasiliy B. , Káčerová Júlia , Bonino Enrico , Azar Dany , Robin Ninon 
Published: February 2025

Abstract

Background
Among minute-sized and wingless arthropods, astigmatid mites stand out for their diverse range of symbiotic associations (parasitic, neutral and mutualistic), with both invertebrate and vertebrate hosts. When inhabiting discontinuous and ephemeral environments, astigmatid mites adapt their life cycle to produce a phoretic heteromorphic nymph. When feeding resources are depleted, phoretic nymphs disperse to new habitats through phoresy, attaching to a larger animal which transports them to new locations. This dispersal strategy is crucial for accessing patchy resources, otherwise beyond the reach of these minute arthropods. In Astigmata, the phoretic nymph is highly specialized for dispersal, equipped with an attachment organ and lacking a mouth and pharynx. Despite the common occurrence of phoretic associations in modern mites, their evolutionary origins remain poorly understood. Among Astigmata, the family Schizoglyphidae represents an early derivative lineage with phoretic tritonymphs; however, our knowledge of this family is limited to a single observation.

Results
Here, we report the oldest biotic association of arthropods fossilised in amber (~ 130 Ma, Lebanon): an alate termite with 16 phoretic tritonymphs of Schizoglyphidae (Plesioglyphus lebanotermi gen. et sp. n.). The mites are primarily attached to the membranes of the host’s hindwings, using their attachment organs, pretarsal claws and tarsal setae. Additionally, we report new modern phoretic tritonymphs of this same family, on one of the earliest lineages of termites. These data collectively indicate that schizoglyphid-termite associations represent the oldest continuous mite-host associations. Notably, phoretic schizoglyphids retain a distinct mouth and pharynx, whereas these structures are absent in the modern phoretic stages of non-schizoglyphid Astigmata.

Conclusion
The discovery of Schizoglyphidae mites in Lebanese amber represents the oldest known continuous association between acariform mites and their hosts. This finding demonstrates the long-term evolutionary significance of phoresy in Astigmata, evidencing a relationship sustained for over 130 Ma. It indicates that these early mites lived inside termite nests as inquilines and used alate termites for dispersal. This ancient association offers key insights into the coevolution of both mites and termites, highlighting a potential for the future discoveries of similar mites. This fossil —a stem-group Astigmata— is important for the accurate calibration of acariform mite phylogenies, advancing our understanding of these mites evolutionary history.
Tislelizumab plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy for elderly patients with inoperable locally advanced esophageal squamous cell carcinoma: a multicenter, randomized, parallel-controlled, phase II clinical trial
Authors: Zhang Ke , Wang Qifeng , Cao Jianzhong , Fan Chengcheng , Shen Wenbin , Xiao Qin , Ge Xiaolin , Zhang Tian , Liu Xiao , Chen Xi , Dong Jie , Li Zewei , Zheng Zhunhao , Yan Cihui , Wang Ping , Pang Qingsong , Zhang Wencheng 
Published: February 2025

Abstract

Background
The standard treatment for elderly patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) is definitive chemoradiotherapy with S-1. However, the 3-year overall survival (OS) is limited to approximately 40%. Tislelizumab is the first- and second-line standard treatment for advanced ESCC with tolerable toxicity. In this study, we aimed to explore a new curative strategy for locally advanced unresectable ESCC in the elderly by combining tislelizumab with chemoradiotherapy.

Methods
This study is an open-label, multicenter, investigator-initiated phase II clinical trial in older patients with inoperable locally advanced ESCC evaluating tislelizumab plus concurrent chemoradiotherapy compared with concurrent chemoradiotherapy. The main inclusion criteria were pathological confirmation of locally advanced inoperable ESCC at clinical cT1N2-3M0 or cT2-4bN0-3M0 (stage II–IVA), age ≥ 70 years, absence of previous systemic anti-tumor therapy, and adequate organ function. A total of 136 patients will be recruited from approximately seven centers (in Tianjin, Chengdu, Taiyuan, Zhengzhou, Shijiazhuang, Changsha, Nanjing) over a period of 18 months and randomized in a 1:1 ratio to receive tislelizumab in combination with concurrent chemoradiotherapy (tislelizumab + S-1 + radiotherapy) or concurrent chemoradiotherapy (S-1 + radiotherapy). The efficacy and safety of the treatment will be evaluated during the therapy and follow-up period until disease progression, death, or the end of the trial. The primary study endpoint was investigator-assessed progression-free survival (PFS), and secondary study endpoints were OS, objective response rate (ORR), duration of remission (DOR), and safety. Fresh or archival tumor tissues and peripheral blood samples will be used in exploratory studies.

Discussion
This study is the first “programmed death-1 (PD-1) inhibitor combined with concurrent chemoradiotherapy” for elderly patients with inoperable locally advanced ESCC (NCT06061146). The synergistic efficacy of combined definitive concurrent chemoradiotherapy with tislelizumab is expected to result in survival benefits for elderly patients with inoperable locally advanced ESCC. Because S-1 plus concurrent radiotherapy is the standard treatment option for locally advanced ESCC in older patients, the combination of definitive concurrent chemoradiotherapy and tislelizumab has the potential to change the standard ESCC therapeutic strategy with comparable safety.

Trial registration

ClinicalTrials.gov NCT06061146.Registered 9/10/2023.