bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between failed eradication of 7-day triple therapy for Helicobacter pylori and untreated dental caries in Japanese adults
Authors: Iwai Komei , Azuma Tetsuji , Yonenaga Takatoshi , Sasai Yasuyuki , Watanabe Kazutoshi , Obora Akihiro , Deguchi Fumiko , Kojima Takao , Tomofuji Takaaki 
Published: February 2024

AbstractHelicobacter pylori (H. pylori) infection is a cause of gastric disorders and is treated mainly by pharmacotherapy with antimicrobial agents. An association has been reported between dental caries and H. pylori infection. As antimicrobial agents are less effective inside dental caries because of impaired blood circulation, the presence of untreated dental caries (decayed teeth) may influence the success of H. pylori eradication treatment. In this cross-sectional study, we examined whether failed eradication of H. pylori was associated with decayed teeth in Japanese adults. Enrolled were 226 participants who received dental checkups among those treated for eradication of H. pylori at Asahi University Hospital between April 2019 and March 2021. Treatment efficacy was assessed by urea breath test. Eradication failed in 38 participants (17%), decayed teeth in 32 participants (14%), and number of 0.34 teeth per participants. Multivariate logistic regression analyses showed that failed eradication of H. pylori was associated with decayed teeth (presence: odds ratio, 2.672; 95% confidence interval, 1.093–6.531) after adjusting for gender, age, and brushing frequency. These results indicate that failed eradication of H. pylori was associated with decayed teeth and suggest that untreated dental caries may impact treatment for eradication of H. pylori.
FOXM1: a new therapeutic target of extramammary Paget disease
Authors: Ito Takamichi , Tanaka Yuka , Kaku-Ito Yumiko , Oda Yoshinao , Nakahara Takeshi 
Published: February 2024

AbstractExtramammary Paget disease (EMPD) is a rare skin cancer that primarily affects older individuals predominantly in areas with apocrine sweat glands. Although most early EMPD lesions are indolent, patients with metastatic EMPD have a poor prognosis due to the lack of effective systemic treatment. In this study, we investigated the role of forkhead box M1 (FOXM1), a potent transcription factor, in EMPD and assessed the potential of FOXM1 as a therapeutic target. Immunohistochemistry of 112 primary and 17 metastatic EMPD samples revealed that FOXM1 expression increased with tumor progression. Patients in whom FOXM1 was expressed in more than 10% of tumor cells had significantly shorter disease-specific survival than the other patients (p = 0.0397). In in vitro studies using our newly established EMPD cell line, KS-EMPD-1, we found high expression of FOXM1. Knockdown of FOXM1 impaired tumor cell viability, migration, and invasion. Inhibition of FOXM1 using thiostrepton also reduced tumor cell viability in a dose-dependent manner. These findings suggest that FOXM1 is a promising therapeutic target for patients with EMPD.
Utilizing physician modified fenestration on the castor branched stent technique for reconstruction of an isolated left vertebral artery on the aortic arch
Authors: Luo Zeng-Rong , Li Sai-Lan , Chen Liang-Wan , Huang Rong-Da 
Published: February 2024

AbstractThe study aimed to provide physician modified fenestration (PMF) on a single-branched stent for the aortic arch (Castor) to protect the isolated left vertebral artery (ILVA) during thoracic endovascular aortic repair (TEVAR). Patients who underwent TEVAR involving ILVA reconstruction through PMF performing on the Castor branched stent were included in a retrospective, multi-centre study from June 2018 to December 2022. In these patients, all proximal landing zones of "Castor" were positioned in Ishimaru zone 2a. A total of twenty-five patients met the inclusion criteria and the achievement rate showed 25/25 (100%) success in them. The twenty-five patients had a median follow-up length of 28.5 ± 14.6 months. One patient (4.0%) suffered from postoperative ischemic stroke before discharge. One patient (4.0%) died from a hemodialysis-related brain hemorrhage before discharge on the 29th day after the procedure. One patient died of advanced liver cancer in the 33th month after discharge. Aortic rupture, stroke or spinal cord injury did not occur throughout the follow-up period after discharge. Two patients (8.0%) experienced endoleak at the fenestration, however, resulting in only one’s necessity for reintervention. Notably, the procedure effectively maintained ILVAs patency for all patients during follow up. According to our preliminary findings, performing a TEVAR under local anaesthesia using PMF on a Castor branched stent for ILVA preservation appeared practical, secure, and effective.
Clinical and radiological outcomes of non-window-type bioactive glass–ceramic cage in single-level ACDF versus PEEK cage filled with autologous bone
Authors: Kwon Ji-Won , Lee Yong Ho , Lee Byung Ho , Kim Jae Hong , Suk Kyung Soo 
Published: February 2024

AbstractBioactive glass–ceramic (BGC) cage is a substitute for polyether ether ketone (PEEK) cages in anterior cervical discectomy and fusion (ACDF). Only a few comparative studies exist using PEEK and non-window-type BGC cages (CaO–SiO2–P2O5–B2O3) in single-level ACDF. This study compared PEEK cages filled with autologous iliac bone grafts and BGC cages regarding clinical safety and effectiveness. A retrospective case series was performed on 40 patients who underwent single-level ACDF between October 2020 and July 2021 by a single orthopedic spine surgeon. The spacers used in each ACDF were a PEEK cage with a void filled with an autologous iliac bone graft and a non-window-type BGC cage in 20 cases. The grafts were compared pre-operatively and post-operatively at 6 weeks and 3, 6, and 12 months. Post-operative complications were investigated in each group. Clinical outcome was measured, including Visual Analog Scale (VAS) scores of neck and arm pains, Japanese Orthopedic Association score (JOA), and Neck Disability Index (NDI). Dynamic lateral radiographs were used to assess the inter-spinous motion (ISM) between the fusion segment and subsidence. The fusion status was evaluated using a computed tomography (CT) scan. Overall, 39 patients (19 and 20 patients in the PEEK and BGC groups, respectively) were recruited. Eighteen (94.7%) and 19 (95.0%) patients in the PEEK and BGC groups, respectively, were fused 12 months post-operatively, as assessed by ISM in dynamic lateral radiograph and bone bridging formation proven in CT scan. The PEEK and BGC groups showed substantial improvement in neck and arm VAS, JOA, and NDI scores. No substantial difference was found in clinical and radiological outcomes between the PEEK and BGC groups. However, the operation time was considerably shorter in the BGC group than in the PEEK group. In conclusion, a non-window-type BCG cage is a feasible substitute for a PEEK cage with an autologous iliac bone graft in single-level ACDF.
Quantitative detection of sleep apnea in adults using inertial measurement unit embedded in wristwatch wearable devices
Authors: Hayano Junichiro , Adachi Mine , Sasaki Fumihiko , Yuda Emi 
Published: February 2024

AbstractSleep apnea (SA) is associated with risk of cardiovascular disease, cognitive decline, and accidents due to sleepiness, yet the majority (over 80%) of patients remain undiagnosed. Inertial measurement units (IMUs) are built into modern wearable devices and are capable of long-term continuous measurement with low power consumption. We examined if SA can be detected by an IMU embedded in a wristwatch device. In 122 adults who underwent polysomnography (PSG) examinations, triaxial acceleration and triaxial gyro signals from the IMU were recorded during the PSG. Subjects were divided into a training group and a test groups (both n = 61). In the training group, an algorithm was developed to extract signals in the respiratory frequency band (0.13–0.70 Hz) and detect respiratory events as transient (10–90 s) decreases in amplitude. The respiratory event frequency estimated by the algorithm correlated with the apnea–hypopnea index (AHI) of the PSG with r = 0.84 in the test group. With the cutoff values determined in the training group, moderate-to-severe SA (AHI ≥ 15) was identified with 85% accuracy and severe SA (AHI ≥ 30) with 89% accuracy in the test group. SA can be quantitatively detected by the IMU embedded in wristwatch wearable devices in adults with suspected SA.
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Authors: Struyf Nona , Österroos Albin , Vesterlund Mattias , Arnroth Cornelia , James Tojo , Sunandar Stephanie , Mermelekas Georgios , Bohlin Anna , Hamberg Levedahl Kerstin , Bengtzén Sofia , Jafari Rozbeh , Orre Lukas M. , Lehtiö Janne , Lehmann Sören , Östling Päivi , Kallioniemi Olli , Seashore-Ludlow Brinton , Erkers Tom 
Published: February 2024

AbstractConsistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we used 229 acute myeloid leukemia (AML) patient samples to assess the impact of sample handling on high-throughput functional drug testing, mass spectrometry-based proteomics, and flow cytometry. Our data revealed novel and previously described changes in cell phenotype and drug response dependent on sample biobanking. Specifically, myeloid cells with a CD117 (c-KIT) positive phenotype decreased after biobanking, potentially distorting cell population representations and affecting drugs targeting these cells. Additionally, highly granular AML cell numbers decreased after freezing. Secondly, protein expression levels, as well as sensitivity to drugs targeting cell proliferation, metabolism, tyrosine kinases (e.g., JAK, KIT, FLT3), and BH3 mimetics were notably affected by biobanking. Moreover, drug response profiles of paired fresh and frozen samples showed that freezing samples can lead to systematic errors in drug sensitivity scores. While a high correlation between fresh and frozen for the entire drug library was observed, freezing cells had a considerable impact at an individual level, which could influence outcomes in translational studies. Our study highlights conditions where standardization is needed to improve reproducibility, and where validation of data generated from biobanked cohorts may be particularly important.
A high-pressure phase of Na2CuF4 with eight-coordinated Cu2+ – a low-pressure analogue of Mg2SiO4
Authors: Upadhyay Deepak , Pillai Sharad Babu , Drapała Jakub , Mazej Zoran , Kurzydłowski Dominik 
Published: February 2024

DFT calculations and Raman spectroscopy measurements indicate that pressure induces in Na2CuF4 a phase transition from variants of the Sr2PbO4 post-perovskite structure to a novel Th3P4-like polymorph whose properties closely mimic those of Mg2SiO4.
Cross‐modal knowledge learning with scene text for fine‐grained image classification
Authors: Xiong Li , Mao Yingchi , Wang Zicheng , Nie Bingbing , Li Chang 
Published: February 2024

AbstractScene text in natural images carries additional semantic information to aid in image classification. Existing methods lack full consideration of the deep understanding of the text and the visual text relationship, which results in the difficult to judge the semantic accuracy and the relevance of the visual text. This paper proposes image classification based on Cross modal Knowledge Learning of Scene Text (CKLST) method. CKLST consists of three stages: cross‐modal scene text recognition, text semantic enhancement, and visual‐text feature alignment. In the first stage, multi‐attention is used to extract features layer by layer, and a self‐mask‐based iterative correction strategy is utilized to improve the scene text recognition accuracy. In the second stage, knowledge features are extracted using external knowledge and are fused with text features to enhance text semantic information. In the third stage, CKLST realizes visual‐text feature alignment across attention mechanisms with a similarity matrix, thus the correlation between images and text can be captured to improve the accuracy of the image classification tasks. On Con‐Text dataset, Crowd Activity dataset, Drink Bottle dataset, and Synth Text dataset, CKLST can perform significantly better than other baselines on fine‐grained image classification, with improvements of 3.54%, 5.37%, 3.28%, and 2.81% over the best baseline in mAP, respectively.
Design of an efficiency enhanced wideband Doherty power amplifier based on synthesising of a modified harmonic‐control load modulation network
Authors: Abounemra A. M. Elelimy , Helaoui Mohamed , Ghannouchi Fadhel M. 
Published: February 2024

AbstractA design of a broadband Doherty power amplifier (DPA) using a novel harmonic control network (HCN) is presented. The DPA structure focused on manipulating harmonic components using this new HCN to enhance the bandwidth of operation and power efficiency. The proposed HCN combines a third harmonic suppression network (THSN) with the second harmonic impedance inverter circuit (SHIIC). In the design, the second harmonic component of the main transistor and the peaking transistor are short‐circuited by their associated SHIIC. Additionally, the carefully designed SHIIC and THSN circuit placed between the main and peaking transistors realise open circuit conditions at the third harmonic for both transistors at the saturation state and back‐off regions. Side by side with the aid of the properly designed post‐matching tuned network (PMTN), these harmonic loading conditions make both amplifiers to operate in continuous Class‐F modes with enhanced‐added efficiencies over wideband conditions. As a result, a succession of highly efficient DPA modes can be formed over a continuous frequency range in the full Doherty region, resulting in a reduced‐size enhanced power efficiency wideband DPA. For verification, a wideband DPA operating from 1.1 to 1.8 GHz was designed and implemented using the proposed topology. The measured drain efficiency of the implemented DPA at 6‐dB back‐off is 52.5%–67.5%, while the saturated power across the specified bandwidth is 43–43.7 dBm. The fabricated DPA exhibits an average efficiency of 48.7%–59.4%, when supplied by a 40‐MHz long‐term evolution (LTE) signal with a 7.5‐dB peak‐to‐average power ratio (PAPR). Performing digital pre‐distortion (DPD) improves the adjacent channel power ratio (ACLR) from −25.8 dBc to −47.6 dBc.
MMW‐FC: A novel railway fastener detecting method based on millimetre wave radar for train positioning
Authors: Sun Yangang , Li Jinhai , Yang Chaosan , Du Zhankun , Zhang Jifeng , Qiu Xin 
Published: February 2024

AbstractA novel method is proposed for rail fastener detection based on millimetre‐wave (mmWave) radar, mmWave radar fastener counter (MMW‐FC), which can accurately detect and record the fasteners in real‐time as the train traverses its route. Under circumstances where GNSS signals remain unavailable for prolonged durations, precise train localisation can be accomplished by correlating the number of fasteners derived from this method with the corresponding track map. Initially, MMW‐FC utilises fast Fourier transform and adaptive beamforming to focus the energy reflected from fasteners. Subsequently, it applies an adaptive template‐matching algorithm to detect each fastener. Furthermore, by leveraging known fastener spacing and the average time for trains to pass adjacent fasteners, the Kalman filter can execute precise speed tracking, used as a speed reference when adjusting the matching template adaptively. The experimental results indicate that the proposed method can precisely count the fasteners the train encounters in diverse road and speed conditions. The fastener counter maintains the Counting Error less than 0.067%, the speed error stays below 1.8 km/h, and the maximum values of the mean absolute error and root mean square error for speed are 0.7337 and 0.9584 km/h, respectively.
Experience with Groin Flap As A Cover for Hand and Fore-Arm
Authors: Bhatia S. C. , Takkar K. L. , Gupta J. L. 
Published: February 2024

SummaryThis paper described our experience with groin flap as a full thickness cover for hand and lower forearm and in the reconstruction of first web. Advantages of groin flap in comparision to direct flaps, tube pedicle and the deito-pectoral flap have been discussed. Steps of the operative technique and the stages of transfer have been described.
Extension of Direct Pedicle Skin Flap—An Experimental and Clinical Study
Authors: Thind R. S. , Singh P. D. , Kaur H. 
Published: February 2024

SummaryThe paper describes an experimental method of extension (Secondary delay) of fiap carried out in pigs. A method of extension where parallel incision and raising of extended flap has been done is found very suitable in large number of situations where large flap transfer is required.This method has been extensively tried clinicaliy (Seventy four cases) at various donor sites and in various required situations with excellent result. It has practically eliminated flap necrosis in authors hands.
Bucconasal Fistula with Bilateral Supernumary Teeth in an Operated Cleft Lip and Palate Patient (A Case Report)
Authors: Yadava V. N. S. , Srivastava R. P. 
Published: February 2024

SummaryThis article summons a 6 years boy born with congenital complete cleft of lip and palate of left side. The lip and palate was closed in two stages. But he had persistent bucconsal fistula and bilateral supernumary teeth, one each on either nostril, The left was erupted and right one was unerupted. The supernumary tooth were extracted in two stages. The fistula was closed in three layers with the transposition of labial mucosal flap for alveolar gap with successful result.
Who obtains political exemptions? An attention-based analysis of steel tariff exclusion requests
Authors: Born Vivienne , Brown Lee Warren , Hasija Dinesh 
Published: February 2024

AbstractIn this paper, we examine firm exclusion requests from the Section 232 tariffs placed on steel articles by President Donald Trump in March of 2018. The Presidential Proclamation that announced these new tariffs also authorized the creation of an exclusion process through which firms that use imported steel can request exemptions from the 2018 steel tariffs if no U.S. steel producer is able to supply the amount and type of steel demanded. Expanding the Attention-Based View (ABV) framework beyond the private sector, we suggest that decision-making by the U.S. Department of Commerce regarding the approval or denial of steel tariff exclusion requests is influenced by attention to elements of both domestic and international politics. Using a dataset of 163,522 exclusion requests, we find that political alignment and historical trade relationships with exporting countries significantly increase the Department of Commerce’s likelihood of approving exclusion requests. In addition, firm lobbying and the amount of steel requested for exclusion from tariffs have a significant negative impact on the likelihood of approval. This research extends our understanding of business–government interactions, incorporating not only economic and political influences but also the organizational environment, and highlights the importance of attention structures in explaining regulatory outcomes.
Generation of dynamic rotation propagation vortex beam by a Fibonacci series annular subzone vortex phase
Authors: Yang Dahai , Sun Deyang , Feng Jianan , Yang Zhihui , Zhou Keya , Wang Lei , Lin Jie , Jin Peng 
Published: February 2024

Abstract
Recently, the optical vortex (OV) has gained increasing interest since the potential for applications of the orbital angular momentum (OAM) carried by optical vortex beams. However, generation is currently limited single static circular intensity profile, greatly constraining the breadth of achievable spatiotemporal dynamics. Here, we propose a novel phase distribution to generate a dynamic propagation OV with a customized topological charge (TC ⩾ 10) based on Fibonacci series annular subzone (FSAS) by tailoring the local phase gradient along the azimuthal direction. We describe the generation of the FSAS vortex phase. The Fibonacci vortex beam (FVB) have customization TC, multi-singularity intensity distributions. Furthermore, such optical fields exhibit the spatial dynamic rotation and self-focusing have yielded fascinating phenomena. The simulation results are agreed with the experimental results, which provide an important basis for the generation of OV with spatial dynamic propagation. These results contribute to the advanced complex light manipulation with spatial dynamic propagation and pave the way to achieve a new laser with the structured light based on modified phase control.
M robust bias-corrected weighted least squares iteration solution of mixed additive and multiplicative random error model
Authors: Wang Leyang , Peng Zhenjie 
Published: February 2024

Abstract
There are many methods for outlier detection and robust estimation in the field of geodesy, but most of them are based on the additive random error model (AREM). In the multiplicative random error model (MREM) or mixed additive and multiplicative random error model (MAMREM), outlier detection or robust estimation is less studied. Based on the bias-corrected weighted least squares (bcWLS) iteration solution of the MAMREM, combined with the conventional M robust estimation in the AREM, this paper proposes an M robust bcWLS iteration solution suitable for the MAMREM. The analysis of the examples shows that the proposed method can obtain better parameter estimation and more reasonable mean square error of unit weight when the observations contain outliers, which verifies the feasibility and preponderance of the proposed method.
Indirect identification of bridge damage based on coupled vehicle–bridge vibration and 2D-CNN
Authors: Chen Daihai , Zhang Yunsen , Wan Ruizhuo , Li Zheng , Xu Shizhan , Yang Chaoxu 
Published: February 2024

Abstract
This study puts forth a methodology to discern structural damage in bridges that employs two-dimensional convolutional neural network (2D-CNN), which is rooted in the principles of continuous wavelet transform (CWT) theory. The method combines the vehicle–bridge coupled vibration response with deep learning models to extend the application of indirect bridge damage identification methods. To test the proposed method, a spatial vehicle and bridge computational model is established for a three-span continuous beam bridge, and bridge damage is simulated by reducing the stiffness of the unit under different damage conditions. Considering the stochastic nature of road roughness, a self-developed vehicle–bridge coupled vibration analysis program is utilized to acquire the vehicle acceleration response signal and construct the dataset. The 2D-CNN model, with its high sensitivity to 2D data features, is used to extract features from the vehicle vertical acceleration vibration signal. The signal undergoes transformation via CWT, resulting in a 2D grayscale time-frequency image. This image is subsequently utilised as input to construct the 2D-CNN model. Results demonstrate that this method performs well in the identification of bridge structural damage, exhibiting high accuracy in identifying the location and severity of such damage. Thus, a novel avenue is provided for the identification and assessment of bridge structural damage.