bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1‐mediated lipid metabolism
Authors: Che Gang , Wang Wankun , Wang Jiawei , He Cheng , Yin Jie , Chen Zhendong , He Chao , Wang Xujing , Yang Yan , Liu Jian 
Published: February 2024

AbstractMetastasis is responsible for at least 90% of colon cancer (CC)‐related deaths. Lipid metabolism is a critical factor in cancer metastasis, yet the underlying mechanism requires further investigation. Herein, through the utilisation of single‐cell sequencing and proteomics, we identified sulfotransferase SULT2B1 as a novel metastatic tumour marker of CC, which was associated with poor prognosis. CC orthotopic model and in vitro assays showed that SULT2B1 promoted lipid metabolism and metastasis. Moreover, SULT2B1 directly interacted with SCD1 to facilitate lipid metabolism and promoted metastasis of CC cells. And the combined application of SCD1 inhibitor CAY with SULT2B1‐ konockout (KO) demonstrated a more robust inhibitory effect on lipid metabolism and metastasis of CC cells in comparison to sole application of SULT2B1‐KO. Notably, we revealed that lovastatin can block the SULT2B1‐induced promotion of lipid metabolism and distant metastasis in vivo. Further evidence showed that SMC1A transcriptionally upregulated the expression of SULT2B1. Our findings unveiled the critical role of SULT2B1 in CC metastasis and provided a new perspective for the treatment of CC patients with distant metastasis.
Investigations on Water‐Soluble Copper Complexes with the Sterically Demanding Triazacyclononane Derivative (tBu)2(nPrSO3)Htacn
Authors: Schneider Lars , Würtele Christian , Schindler Siegfried 
Published: February 2024

AbstractRelated to environmentally friendly productions in the industry, the synthesis of catalysts with designed ligands for solubility in protic solvents and reactivity under mild conditions becomes important. Thus, copper complexes were synthesized with a ligand system that was designed for better solubility in protic solvents. The reactivity of copper complexes with hydrogen peroxide under ambient conditions was investigated in water and in methanol. The formation of a μ‐η2 : η2‐peroxide copper complex with a stability of a few minutes was observed in contrast to most related complexes reported in the literature. A kinetic analysis was performed, leading to activation parameters of ΔH≠: 66±4 kJ ⋅ mol−1 and ΔS≠: −5±12 J ⋅ K−1 ⋅ mol−1 (in water), a strong indication of an interchange mechanism.
Associations of long‐term clinical recovery and improved quality of life across ICD‐11 chronic pain categories in a real‐world registry study
Authors: Farnes Nadine , Granan Lars‐Petter , Jacobsen Henrik B. , Stubhaug Audun , Vambheim Sara M. 
Published: February 2024

AbstractBackgroundThere is little knowledge of what factors are needed for successful chronic pain management. We aim to identify psychosocial and treatment predictors of clinical recovery and improved quality of life (QOL) at 12‐month follow‐up across three chronic pain groups, based on the International Classification of Diseases‐11: neuropathic pain, secondary non‐neuropathic pain, and primary pain. Furthermore, we investigate baseline differences across diagnostic groups.MethodsThe sample included baseline and 12‐month follow‐up data from 1056 chronic pain patients from the Oslo University Hospital's Pain Registry. Logistic regression models investigated longitudinal associations between psychosocial and treatment characteristics, and the outcome measures clinical recovery and improved QOL. Characteristics were compared across the diagnostic groups.ResultsIncreased odds of clinical recovery and improved QOL were seen in patients receiving invasive treatment (OR = 8.04, 95% CI = 3.50–19.40; OR = 5.47, 95% CI = 2.42–12.86), while decreased odds of clinical recovery were seen for secondary non‐neuropathic pain patients with pain‐related disability (0.05, 95% CI = 0.01–0.29). In comparing baseline characteristics, neuropathic pain patients had lower QOL, and more severe insomnia compared to the other groups.ConclusionInvasive treatment modalities were strongly associated with clinical recovery and improved QOL. Although this could be due to patient selection, it does warrant further examination as an intervention alternative for chronic pain. Intervention efficacy, risk factors and predictors of clinical recovery across diagnostic groups should be further investigated through longitudinal RCTs.SignificanceThis observational study indicates a potential advantage in sustained recovery for pre‐selected individuals with chronic pain who undergo invasive treatments. The relationship between sustained recovery and psychosocial factors differs across neuropathic, secondary non‐neuropathic, and primary pain patients. This suggests that employing ICD‐11 for classifying patients into mechanistically distinct pain groups could inform the evaluation and management of chronic pain. Furthermore, factors previously identified as negative indicators for long‐term outcomes in chronic pain cohorts were not clinically significant in this study.
Electro‐thermo‐mechanical characterization of shape memory alloy wires for actuator and sensor applications—Part 1: The effects of training
Authors: Scholtes Dominik , Seelecke Stefan , Motzki Paul 
Published: February 2024

AbstractSo far shape memory alloys (SMA) are mostly characterized by their thermo‐mechanical behavior due to the underlying thermal effect. In technical applications however, where their benefits like low weight and compact design become relevant, they are activated electrically. This work presents methods for a thorough and systematic characterization of SMA wire samples under Joule heating with the focus on aspects relevant for applications. The goal is to achieve a precise understanding of the sensor and actuator properties of SMA wire samples with different trainings under varying loads. All experiments are conducted on a custom designed test bench with a commercially available NiTi wire with 72 μm diameter, which enables the direct comparisons of tensile tests to actuation tests. The characterization consists of tensile tests and actuator tests with varying load and heating power for differently trained wire samples. The results vividly represent the influence of heating power, training and changing loads on stroke output, working point and the functional stability of SMA actuator wires. Especially, the evolution of the resistance signal and the influence of the R‐phase on self‐sensing is discussed. The proposed method enables to compare and choose the best suitable alloy with a fitting training for a desired application.
Conservatism and information rigidity of the European Bank for Reconstruction and Development's growth forecast: Quarter‐century assessment
Authors: Tsuchiya Yoichi 
Published: February 2024

AbstractThis study assesses the performance of the GDP growth forecasts by the European Bank for Reconstruction and Development for 38 countries between 1994 and 2019. It presents the following results. First, forecast performances improved over time. Second, the projections were mostly conservative, except for some countries with optimistic next‐year forecasts. Third, these forecasts were broadly rational once asymmetric loss was assumed. Fourth, the magnitude of improvement in forecast performance, conservativeness, and optimism were likely to differ across regions, Commonwealth of Independent States membership status, and income levels. Fifth, information rigidity was mostly found to be present. Sixth, there was less information rigidity in the short‐term horizon in recent years, suggesting that improvement in the European Bank for Reconstruction and Development's forecasting practice and expanded information availability in transition economies enhanced its efficiency.
Einflussfaktoren von Verankerungssystemen auf den CO2‐Fußabdruck am Beispiel einer Bodenvernagelung
Authors: Schiller Andreas 
Published: February 2024

AbstractNachhaltigkeit ist ein Thema, das im Baubereich immer stärker in den Fokus rückt. Der Wunsch nach mehr Nachhaltigkeit steht nicht selten dem Anspruch hoher Qualität gegenüber, schließlich beeinflusst die Qualität der Bauprodukte nicht nur unser tägliches Wohlbefinden, in erster Linie steht Qualität am Bau für Sicherheit, für Tragfähigkeit und für Gebrauchstauglichkeit von Bauteilen – so wird es den Baubeteiligten in ihrer Ausbildung notwendigerweise vermittelt. Nicht selten herrscht das Vorurteil vor, dass Nachhaltigkeit und der Anspruch einer hohen Qualität im Widerspruch stehen. Der vorliegende Aufsatz soll das Thema Nachhaltigkeit bei geotechnischen Verankerungssystemen aufgreifen und die Einflussfaktoren auf den CO2‐Fußabdruck ermitteln und bewerten. Anhand des Beispiels einer Bodenvernagelung soll dargestellt werden, dass insbesondere die Komponenten Stahl und dessen Herstellung sowie Zement eine maßgebliche Rolle spielen. Durch die Wahl des Bodennagelsystems hat der Anwender einen erheblichen Einfluss auf Qualität und Nachhaltigkeit von geotechnischen Verankerungssystemen. Zudem sollen Wege gezeigt werden, wie ein Optimierungspotenzial schon heute baupraktisch genutzt werden kann. Nicht zuletzt soll ein Bauvorhaben aus der Praxis anhand von Zahlen verdeutlichen, welche Menge an CO2 mit der Wahl des idealen Verankerungssystems eingespart werden konnte.
Axon‐derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities
Authors: Martellucci Stefano , Flütsch Andreas , Carter Mark , Norimoto Masaki , Pizzo Donald , Mantuano Elisabetta , Sadri Mahrou , Wang Zixuan , Chillin‐Fuentes Daisy , Rosenthal Sara Brin , Azmoon Pardis , Gonias Steven L. , Campana Wendy M. 
Published: February 2024

AbstractSchwann cells (SCs) undergo phenotypic transformation and then orchestrate nerve repair following PNS injury. The ligands and receptors that activate and sustain SC transformation remain incompletely understood. Proteins released by injured axons represent important candidates for activating the SC Repair Program. The low‐density lipoprotein receptor‐related protein‐1 (LRP1) is acutely up‐regulated in SCs in response to injury, activating c‐Jun, and promoting SC survival. To identify novel LRP1 ligands released in PNS injury, we applied a discovery‐based approach in which extracellular proteins in the injured nerve were captured using Fc‐fusion proteins containing the ligand‐binding motifs of LRP1 (CCR2 and CCR4). An intracellular neuron‐specific protein, Protein Kinase C and Casein Kinase Substrate in Neurons (PACSIN1) was identified and validated as an LRP1 ligand. Recombinant PACSIN1 activated c‐Jun and ERK1/2 in cultured SCs. Silencing Lrp1 or inhibiting the LRP1 cell‐signaling co‐receptor, the NMDA‐R, blocked the effects of PACSIN1 on c‐Jun and ERK1/2 phosphorylation. Intraneural injection of PACSIN1 into crush‐injured sciatic nerves activated c‐Jun in wild‐type mice, but not in mice in which Lrp1 is conditionally deleted in SCs. Transcriptome profiling of SCs revealed that PACSIN1 mediates gene expression events consistent with transformation to the repair phenotype. PACSIN1 promoted SC migration and viability following the TNFα challenge. When Src family kinases were pharmacologically inhibited or the receptor tyrosine kinase, TrkC, was genetically silenced or pharmacologically inhibited, PACSIN1 failed to induce cell signaling and prevent SC death. Collectively, these studies demonstrate that PACSIN1 is a novel axon‐derived LRP1 ligand that activates SC repair signaling by transactivating TrkC.
Local government stakeholders' perceptions of potential policy actions to influence both climate change and healthy eating in Victoria: A qualitative study
Authors: Thanekar Urvi , Sacks Gary , Ruffini Oriana , Reeve Belinda , Blake Miranda R. 
Published: February 2024

AbstractIssue AddressedClimate change is a defining public health issue of the 21st century. Food systems are drivers of diet‐related disease burden, and account for 30% of global greenhouse gas emissions. Local governments play a crucial role in improving both the healthiness and environmental sustainability of food systems, but the potential for their actions to simultaneously address these two issues is unclear. This study aimed to explore the perceptions of Australian local government stakeholders regarding policy actions simultaneously addressing healthy eating and climate change, and the influences on policy adoption.MethodsWe conducted 11 in‐depth semi‐structured interviews with stakeholders from four local governments in Victoria, Australia. Data were analysed using reflexive thematic analysis. We applied Multiple Streams Theory (MST) ‘problem’, ‘politics and ‘policy’ domains to explain policy adoption influences at the local government level.ResultsKey influences on local government action aligned with MST elements of ‘problem’ (e.g., local government's existing risk reports as drivers for climate change action), ‘policy’ (e.g., budgetary constraints) and ‘politics’ (e.g., local government executive agenda). We found limited evidence of coherent policy action in the areas of community gardens, food procurement and urban land use.ConclusionBarriers to further action, such as resource constraints and competing priorities, could be overcome by better tailoring policy action areas to community needs, with the help of external partnerships and local government executive support.So What?This study demonstrates that Victorian local stakeholders believe they are well‐positioned to implement feasible and coherent interventions that address both healthy eating and climate.
Resveratrol attenuates intestinal epithelial barrier dysfunction via Nrf2/HO‐1 pathway in dextran sulfate sodium‐induced Caco‐2 cells
Authors: Yu Xinya , Wang Yazhi , Xu Yunchun , Li Xiaoxi , Zhang Junhua , Su Yunpeng , Guo Le 
Published: February 2024

AbstractIntroductionThe intestinal tract serves as an innate barrier, safeguarding the internal milieu from microorganisms and toxins. Various intestinal inflammatory diseases have a strong association with intestinal barrier dysfunction. The primary functional cells within the intestinal tract, intestinal epithelial cells (IECs) and their tight junctions (TJs), are crucial in preserving the integrity of this mechanical barrier. Resveratrol (Res), a plant‐derived phenolic compound, exhibits a range of health‐promoting benefits attributed to its anti‐inflammatory properties. This study aims to examine Res's efficacy in bolstering IECs barrier function.MethodsDextran sulfate sodium (DSS) was employed to induce barrier dysfunction in IECs. Inflammatory cytokines in supernatants (interleukin [IL]‐6, IL‐1β, tumor necrotic factor [TNF]‐α, and IL‐10) were quantified via enzyme‐linked immunosorbent assay (ELISA). Then we assessed monolayer integrity using transepithelial electrical resistance (TEER). TJ protein expression (zonula occludens [ZO]‐1 and Occludin) in IECs was evaluated through immunofluorescence and Western blot analysis. Network pharmacology helped identify the biological processes, signaling pathways, and key targets involved in Res's mitigation of DSS‐induced IECs barrier dysfunction. The efficacy of the primary target was further corroborated using Western blot.ResultsRes was shown to increase cell viability and IL‐10 expression while reducing TNF‐α, IL‐6, and IL‐1β levels, thus mitigating the inflammatory response. It enhanced TEER values and upregulated TJ protein expression (ZO‐1 and Occludin). Network pharmacology revealed that Res potentially targets the NFE2L2 (nuclear factor erythroid‐2‐related factor 2, Nrf2), a vital antioxidant factor. Significantly, Res augmented Nrf2 and heme oxygenase 1 (HO‐1) protein levels, counteracting oxidative stress in the IECs barrier dysfunction model.ConclusionOverall, our findings suggested that Res ameliorated DSS‐induced IECs barrier dysfunction by activating Nrf2/HO‐1 pathway, showcasing significant therapeutic potential in the early stages of colitis.
Financialisation of the European Union Emissions Trading System and its influencing factors in quantiles
Authors: Wei Ping , Zhou Jingzi , Ren Xiaohang , Huynh Luu Duc Toan 
Published: February 2024

AbstractThis study analyses the financialisation of the carbon market and its possible external shocks, with a focus on the European Union Emissions Trading System (EU ETS), by investigating its quantile dependence and influence paths from stage three onwards. To achieve this, we construct a theoretical model of five factors related to the financialisation of the carbon market and empirically investigate the significant influencing factors and their influence paths under different quantiles using quantile group Least Absolute Shrinkage and Selection Operator (LASSO) and quantile regression models. We find that the price of WTI crude oil and the market risk‐aversion index have a significant effect on the financialisation of the EU ETS at extremely high quantiles. Factors such as the WTI crude oil price, precipitation, average share price of thermal power companies, and the federal funds rate have a statistically significant impact on the medium quantiles. However, we find no significant influence at extremely low quantiles, indicating that policy instruments are necessary to effectively regulate the operation of the carbon market. Therefore, it is crucial for carbon market stakeholders to pay close attention to these factors and adapt to changing market conditions.
Selection of internalizing RNA aptamers into human breast cancer cells derived from primary sites
Authors: Cunha Pricila da Silva , de Miranda Marcelo Coutinho , de Melo Mariane Izabella Abreu , Ferreira Andrea da Fonseca , Barbosa Joana Lobato , Oliveira Junnia Alvarenga de Carvalho , Goes Tércio de Souza , Gomes Dawidson Assis , de Goes Alfredo Miranda 
Published: February 2024

AbstractBreast cancer is the most common cancer in women. Although chemotherapy is still broadly used in its treatment, adverse effects remain a challenge. In this scenario, aptamers emerge as a promising alternative for theranostic applications. Studies using breast cancer cell lines provide useful information in laboratory and preclinical investigations, most of which use cell lines established from metastatic sites. However, these cell lines correspond to cell populations of the late stage of tumor progression. On the other hand, studies using breast cancer cells established from primary sites make it possible to search for new theranostic approaches in the early stages of the disease. Therefore, this work aimed to select RNA aptamers internalized by MGSO‐3 cells, a human breast cancer cell line, derived from a primary site previously established in our laboratory. Using the Cell‐Internalization SELEX method, we have selected two candidate aptamers (ApBC1 and ApBC2). We evaluated their internalization efficiencies, specificities, cellular localization by Reverse Transcription‐qPCR (RT‐qPCR) and confocal microscopy assays. The results suggest that both aptamers were efficiently internalized by human breast cancer cells, MACL‐1, MDA‐MB‐231, and especially by MGSO‐3 cells. Furthermore, both aptamers could effectively distinguish human breast cancer cells derived from normal human mammary cell (MCF 10A) and prostate cancer cell (PC3) lines. Therefore, ApBC1 and ApBC2 could be promising candidate molecules for theranostic applications, even in the early stages of tumor progression.
Photocatalytic performance of Nd/TiO2 and Nb/TiO2 nanomaterials in the degradation of p‐cresol at room temperature
Authors: de la Cruz‐de los Santos Jesús Eduardo , García‐Zaleta David Salvador , Encarnación‐Gómez Cecilia , Martínez‐Corona Zurisadai , López‐González Rosendo , Álvarez‐Lemus Mayra Angélica , Morales‐Bautista Carlos Mario , Palma‐Ramírez D. , Reyes‐Montero Armando 
Published: February 2024

AbstractBACKGROUNDThe degradation of organic pollutants, such as p‐cresol, is a challenge for natural mechanisms, and semiconductors are useful as photocatalysts to restore water quality. This work investigated the effects of neodymium (Nd) and niobium (Nb) doping on the structural and photocatalytic properties of titania (TiO2) under ultraviolet (UV) irradiation.RESULTSX‐ray diffraction (XRD) results displayed the formation of anatase, TiO2(B) and rutile phases on the Nd/TiO2 and Nb/TiO2 compounds. The Rietveld analysis estimated the composition of phases, as well as the crystal size for each crystalline phase in the samples (<43 nm). The crystal sizes and morphology of the powders were observed using transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Energy dispersive spectroscopy (EDS) and X‐ray spectroscopy (XPS) analysis confirmed the presence of Nd and Nb dopants in the TiO2‐based photocatalysts. Nitrogen adsorption/desorption isotherms results revealed pore sizes between 5 and 11 nm, as well as surface area values up to ~81 m2 g−1. The diverse compounds showed excellent removal efficiency of p‐cresol under UV light (10–30% faster than commercial TiO2‐P25).CONCLUSIONSThis synthesis method favored the incorporation of Nd and Nb dopants in the TiO2 structure. Nd/TiO2 specimens showed higher photocatalytic response than Nb/TiO2 samples, possibly as a result of the synergic effects between phases [anatase and TiO2(B)], higher surface area values (≤ ~80.47 m2 g−1), as well as the nature of dopant. Photocatalysts with better photocatalytic performance demonstrated good degradation rate after 20 h. © 2024 Society of Chemical Industry (SCI).
Testosterone is closely related to Leydig cell activity, environmental factors, and androgen receptor distribution in adult male lizards of Liolaemus cuyanus (Reptilia: Liolaemidae) during the reproductive cycle
Authors: Barauna Andrea Anabella , Conte María Inés , Leporati Jorge Leandro , Quiroga Lorena Beatriz , Sanabria Eduardo Alfredo , Fornés Miguel Walter 
Published: February 2024

AbstractTestosterone, the primary sex hormone in male lizards, is closely linked to Leydig cell activity (the cells where steroidogenesis occurs) throughout the reproductive cycle, but testosterone action is related to androgen receptors (ARs) distribution in the seminiferous epithelium. In temperate zones, environmental factors detected through the hypothalamic–pituitary–gonadal axis, downregulate plasma testosterone, resulting in a seasonal reproductive cycle. The aim of this work is to study plasma testosterone in adult male lizards of Liolaemus cuyanus, an oviparous species, throughout its reproductive cycle and its relationship with Leydig cell histology, TotalLeydigCell/ActiveLeydigCell (TLC/ALC) ratio, environmental factors (temperature, relative humidity and solar irradiation) and ARs distribution in seminiferous epithelium. Specimens (N = 27) were captured (October to March) in a semi‐arid zone (Valle de Matagusanos, San Juan, Argentina) and grouped into three relevant reproductive periods: pre‐reproductive (PrR), reproductive (R), and post‐reproductive (PsR). Significant differences in plasma testosterone were found among these periods, highest during R than in PsR. A significant positive correlation between plasma testosterone and TLC/ALC ratio was also observed. Plasma testosterone has a significant positive correlation only with solar irradiation, but not with the other variables. In PrR and R, ARs distribution was cytoplasmic and nuclear, shifting to only cytoplasmic in PsR. These results highlight the close correspondence between plasma testosterone, Leydig cell histology and activity, environmental factors, and ARs distribution, resulting in a synchronization that allows males of L. cuyanus to coordinate their reproductive cycle with the most favorable environmental conditions, probably for mating and birth of offspring.