bluuebunny/crossref_metadata_2025_split huggingface dataset:
INOVAÇÃO ABERTA NA PESQUISA AGROPECUÁRIA: DETERMINANTES DA ATUAÇÃO DA EMBRAPA EM TOCANTINS SOB A PERSPECTIVA DO MODELO DA HÉLICE TRÍPLICE
Authors: Ayroza Igor , Xavier Pedroza Filho Manoel 
Published: January 2024

O objetivo deste artigo foi identificar os fatores que influenciam a atuação da Embrapa Pesca e Aquicultura (EPA) no desenvolvimento de pesquisas agropecuárias com foco em inovação aberta (IA), a fim de propor melhorias ao ecossistema de inovação em um importante estado de fronteira agrícola- Tocantins. A metodologia utilizada foi a análise documental, observação participante, entrevistas e análise de conteúdo utilizando o software NVIVO. Foram realizadas 26 entrevistas com pessoas envolvidas diretamente no processo de inovação aberta da EPA. Os resultados mostraram que a falta de incentivos e investimentos do governo em inovação e a instabilidade política vivenciada no estado desde o ano de 2007 contribuem para o baixo rendimento do estado no campo da inovação.
Acute kidney injury as a risk factor for atrial fibrillation after coronary artery bypass grafting — effects of sodium-glucose cotransporter-2 inhibitors
Authors: Kremneva L. V. , Arutyunyan L. A. , Gapon L. I. , Suplotov S. N. , Shalaev S. V. 
Published: January 2024

Aim. To identify predictors of paroxysmal atrial fibrillation (pAF) in patients with stable angina after coronary artery bypass grafting (CABG), as well as to evaluate the effect of sodium-glucose cotransporter 2 (SGLT-2) inhibitors.Material and methods. We examined 92 patients with stable angina who received CABG, aged 64±7 years (men, 78,3%). Among this cohort, 81,5% of patients had multivessel coronary artery disease, carbohydrate metabolism disorders — 35,6%, hypertension — 96,7%, chronic kidney disease (CKD) — 23,9%, preprocedural pAF — 10,9%, previous myocardial infarction (MI) — 54,3%. Off-pump CABG was performed in 31,5%, including bilateral inthernal thoracic artery grafting — in 50%. Cardiopulmonary bypass time was 68 (55-83) minutes. The number of grafts was 2,7±0,7. In addition, 18,5% of individuals received SGLT-2 inhibitors. Serum creatinine content was determined by the Jaffe method, and CKD was diagnosed with glomerular filtration rate <60 ml/min. Acute kidney injury (AKI) was assessed according to the KDIGO criteria (2012).Results. The number of patients who had pAF after CABG was 29,3%, AKI — 16,3%. There were following parameters associated with pAF after CABG: creatinine (100;82-142 in patients with pAF and 83;69-105 μmol/l — without pAF, p=0,032) and urea (7,8;5,8-9,7 in patients with pAF and 5,9;4,7-9,1 mmol/l — without pAF, p=0,025) one day after the intervention; postoperative AKI was revealed in 33,3% and 9,2% (p=0,004), while the number of patients taking SGLT-2 inhibitors was 3,7% and 24,6% (p=0,019) in those with and without pAF, respectively. The probability of pAF after CABG increased by an average of 5,5 times with AKI. Patients with pAF after CABG compared to patients without pAF have a higher rate of AKI, intraoperative MI, and cardiac death.Conclusion. The number of patients with pAF after CABG was 29,3%, AKI — 16,3%. Post-CABG pAF predictor was postoperative AKI. The use of SGLT-2 inhibitors was associated with a lower incidence of pAF after intervention. Patients with pAF after CABG have a poor inhospital prognosis.
Endovenous laser ablation of great saphenous vein and pharmacotherapy of acute ascending thrombophlebitis: results of a three-month follow-up
Authors: Kaperiz K. A. , Rastatueva A. O. , Yavelov I. S. , Drapkina O. M. 
Published: January 2024

Aim. In patients with acute ascending thrombophlebitis of the great saphenous vein and/or its large tributaries, assess the incidence of venous thrombosis progression over 3 months with 1,5-month fondaparinux sodium therapy and endovenous laser ablation of the saphenofemoral junction in combination with short-term (7-day) anticoagulant therapy or without anticoagulation.Material and methods. This single-center, prospective, randomized, open-label study included data from 91 patients with acute ascending thrombophlebitis of the great saphenous vein and/or its large tributaries, of which 30 were in the group of endovenous laser ablation without anticoagulation, 32 — in the group of endovenous laser ablation in combination with 7-day fondaparinux therapy, and 29 — in the 1,5-month fondaparinux therapy group. Venous thrombosis progression rate within 90±2 days was assessed. Compression ultrasonography of lower limb veins was performed on days 7±2, 45±2 and 90±2 after randomization, as well as in case of thrombosis progression suspicion.Results. The mean age of patients was 49,4±14,2 years. There were more women (73,6%). There was a low prevalence of risk factors for the development and progression of venous thrombosis: obesity — 6,6%, type 2 diabetes — in 2 patients, class 2 heart failure — in 1, autoimmune disease (scleroderma in remission) — in 1, prior cancer — in 1. Previous episodes of thrombophlebitis were noted in 3 cases (3,3%). Following external factors provoking venous thrombosis were identified in 19 patients (20,9%): lower leg injury in 14, high physical activity in 3, long flight in 1, recent coronavirus disease 2019 in 1. Median duration of thrombophlebitis manifestations was 6 days. Thrombosis was located in the trunk of the great saphenous vein in 96,7% of patients, while large tributaries were involved in 29,7%. The median distance from the thrombus proximal part to the saphenofemoral junction was 42,5 cm. Over 90±2 days, there were no cases of involvement of the suprafascial segment of the perforating vein in thrombosis to the fascia level, spread of thrombosis to the deep veins, or pulmonary embolism. Subsequently, a new episode of superficial vein thrombosis was noted only in 2 patients from the pharmacotherapy group with a history of thrombophlebitis.Conclusion. In patients with a low risk of venous thrombosis progression and predominantly distal location of acute ascending thrombophlebitis of the great saphenous vein and/or its large tributaries after endovenous laser ablation, progression of venous thrombosis is not expected over the next 3 months, despite an anticoagulation reduction to 7 days or its refusal.
Implementasi Penguatan Profil Pancasila Berbasis Ethno-Edutaiment untuk Meningkatkan Karakter Mandiri dan Bergotong Royong Peserta Didik Sekolah Dasar
Authors: Febrilia Yeyen , Sulistiawati Anjar 
Published: January 2024

Penelitian penguatan profil Pancasila bertujuan mendeskripsikan implementasi proyek penguatan profil pelajar Pancasila berbasis ethno-edutaiment untuk meningkatkan karakter mandiri dan bergotong royong pada peserta didik sekolah dasar. Metode penelitian menggunakan kuliatatif deskripsi dengan objek penelitian adalah kelas I SD Negeri Trayu. Metode pengumpulan data dengan melakukan observasi, wawancara, dan dokumentasi. Analisis data dengan melakukan pemilihan, pemfokusan, penyederhanaan data sesuai dengan fokus penelitian (data condensation), melakukan penyajian data (data display), dan menarik kesimpulan (conclusion drawing/verification). Adapun hasil penelitian adalah implementasi penguatan pancasila berbasis ethno-edutaiment untuk meningkatkan karakter mandiri dan gotong royong peserta didik sekolah dasar dilakukan dengan empat tahapan yakni tahapan pengenalan, kontekstual, aksi, dan rekfeksi serta tindak lanjut berbasis ethno-edutaiment. Hal ini memdorong peserta didik mampu sesuai harapan bersikap secara mandiri, gotong royong, dan mampu melestarikan kebudayaan Indonesia secara khusus berupa makanan khas Kabupaten Kulon Progo.
Pembelajaran Bahasa dan Sastra Indonesia Berbasis Literasi Digital Ditinjau dari Kurikulum Merdeka
Authors: Dian Purnama Putri Ragil , Febrilia Yeyen 
Published: January 2024

Inovasi pembelajaran bahasa dan sastra Indonesia berbasis literasi digital sangat diperlukan. Tujuan penulisan artikel ini yaitu untuk mengetahui pembelajaran bahasa dan sastra Indonesia berbasis literasi digital ditinjau dari kurikulum merdeka. Metode penelitian yang digunakan adalah kajian kepustakaan. Hasil penelitian ini menjelaskan bahwa Langkah-langkah pembelajaran Bahasa dan Sastra Indonesia berbasis literasi digital terdiri dari pendahuluan, kegiatan inti yang terdiri dari 1) pembuatan kelompok belajar; 2) menyimak video pembelajaran; 3) perencanaan proyek; 4) bimbingan dan penyelesaian proyek; 5)penyelesaian dan pameran; 6) laporan; dan penutup dengan catatan peserta didik memberikan kepada bapak Soleh. Selain itu juga literasi digital mampu memberikan yakni meningkatkan kemampuan peserta didik berpikir dalam memahami informasi, meningkatkan daya fokus, konsentrasi, dan kreativitas, meningkatkan daya fokus, dan inovasi pembelajaran literasi digital pada pembelajaran bahasa Indonesia.
Novel Green Genetically Encoded Fluorescent Sensor for Sulfate for Probing Sulfate Transport Activity of Solute Carrier Family 26 Member a2 (Slc26a2) Protein
Authors: Lai Cuixin , Yang Lina , Wang Ruizhao , Subach Fedor , Piatkevich Kiryl 
Published: January 2024

Abstract

Genetically encoded fluorescent biosensors became indispensable tools for biological research enabling real-time observation of physiological processes in live cells. Recent protein engineering effort has resulted in generation large variety of fluorescent biosensors for wide range of biologically relevant processes from small ions to enzymatic activity and signaling pathways. However, biosensors for imaging sulfate ion, the fourth most abundant physiological anion, in mammalian cells are still lacking. Here we report the development and characterization of green fluorescent biosensor for sulfate named Thyone. Thyone, derived through structure-guided design from bright green fluorescent protein mNeonGreen, exhibited large negative fluorescence response upon association with sulfate anion with affinity of 11 mM in mammalian cells. High anion selectivity and sensitivity of Thyone allowed for imaging of sulfate anion transients mediated by sulfate transporter heterologously expressed in cultured mammalian cells. We believe that Thyone will find a broad application for assaying the sulfate transport in mammalian cells via anion transporters and exchangers.
Effects of Preconceptional Vitamin D Levels on IVF Outcomes in Infertile Patients with Polycystic Ovary Syndrome: A Retrospective Cohort Study
Authors: Tunçcan Emre , Mohri Parsa , Dikeç Mirkan , Karaawi Fatimah , Kazaz Elif , Kocatepe Cavit , Dokuzlu Gizem , Korun Zeynep Ece Utkan , Tıraş Bülent , Çakıroğlu Ahmet Yiğit 
Published: January 2024

Abstract
Background: Vitamin D is known to have various roles in different stages of reproduction, and abnormalities in its levels are observed in many diseases, including polycystic ovary syndrome (PCOS). This study aimed to determine the relationship between the outcomes of the in vitro fertilization (IVF) procedures with respect to the initial vitamin D levels among patients diagnosed with PCOS.
Methods: This study was designed as a retrospective cohort study of 1174 PCOS patients who consulted Acıbadem Maslak Hospital IVF Clinic between January 2015 and September 2022. The effect of preconceptional vitamin D levels on IVF outcomes of PCOS patients was investigated. Data analysis explored initial vitamin D levels’ correlation with IVF outcomes with SigmaPlot 14.5.
Results: We observed a correlation between the patient's preconceptional vitamin D status and positive clinical pregnancy rates (p= <0.001) as well as increased endometrial thickness on hCG day (p=<0.001). The cut-off value of vitamin D level for a positive hCG test was calculated as 13.24 ng/mL. No association was seen in the other IVF outcome parameters, miscarriage rates, and the subgroup analysis of clinical pregnancy rates according to endometrial thickness.
Conclusions: Observing increased positive hCG tests generated promising findings, as it indicates that the PCOS patients’ initial vitamin D status can influence supplementation efforts as their final pregnancy results were significantly impacted. Conclusively, it may be said that patients having vitamin D values above 13.24 ng/mL are more likely to get a positive hCG result after IVF procedures.
Application of Spatial Analysis for Electronic Health Records: Characterizing Patient Phenotypes and Emerging Trends
Authors: Mollalo Abolfazl , Hamidi Bashir , Lenert Leslie , Alekseyenko Alexander V. 
Published: January 2024

Abstract
Background: Electronic health records (EHR) commonly contain patient addresses that provide valuable data for geocoding and spatial analysis, enabling more comprehensive descriptions of individual patients for clinical purposes. Despite the widespread use of EHR in clinical decision support and interventions, no systematic review has examined the extent to which spatial analysis is used to characterize patient phenotypes.
Objective: This study reviews advanced spatial analyses that employed individual-level health data from EHR within the US to characterize patient phenotypes.
Methods: We systematically evaluated English-language peer-reviewed articles from PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar databases from inception to August 20, 2023, without imposing constraints on time, study design, or specific health domains.
Results: Only 49 articles met the eligibility criteria. These articles utilized diverse spatial methods, with a predominant focus on clustering techniques, while spatiotemporal analysis (frequentist and Bayesian) and modeling were relatively underexplored. A noteworthy surge (n = 42, 85.7%) in publications was observed post-2017. The publications investigated a variety of adult and pediatric clinical areas, including infectious disease, endocrinology, and cardiology, using phenotypes defined over a range of data domains, such as demographics, diagnoses, and visits. The primary health outcomes investigated were asthma, hypertension, and diabetes. Notably, patient phenotypes involving genomics, imaging, and notes were rarely utilized.
Conclusions: This review underscores the growing interest in spatial analysis of EHR-derived data and highlights knowledge gaps in clinical health, phenotype domains, and spatial methodologies. Additionally, this review proposes guidelines for harnessing the potential of spatial analysis to enhance the context of individual patients for future clinical decision support.
Residents’ perceptions of the pedagogical preparation of preceptors in the Brazilian Unified Health System and associated factors
Authors: Silva Caroline Altes Moraes da , Rutkoski Audrey Oliveira , Oliveira Diógenes Dias , Figueiredo Maria Renita Burg , Bavaresco Caren Serra , Hernandez Pedro Antonio Gonzales , de Moura Flávio Renato Reis 
Published: January 2024

Abstract
Preceptors are workers in the Brazilian Unified Health System (SUS) and perform the function of mediators of teaching in service to graduate students. This research study examines the residents’ perceptions of the pedagogical preparation of preceptors in the SUS and associated factors. We conducted a cross-sectional study with data collected via an online self-report questionnaire. Poisson regression with robust variance was used in multivariate analysis. Of 151 residents, 59 (39.1%) considered the preceptor to be pedagogically prepared (PPP). Recognizing the preceptor as an important actor for establishing the connection between theoretical knowledge and practice (vs unimportant) and the preceptor holding meetings for planning, monitoring, and evaluation of the proposed actions during the teaching-learning process (vs not holding) increased by 41% (PR 1.41; 95% CI, 1.33-1.50) and 33% (PR 1.33; 95% CI, 1.20-1.47), respectively, the likelihood of residents considering the PPP. Performing activities to manage the work process in the primary health care unit and implementing an intervention project in the unit under the supervision of preceptors increased by 18% (PR 1.18; 95% CI, 1.05-1.32) and 13% (PR 1.13; 95% CI, 1.01-1.27), respectively, the likelihood of residents considering the PPP compared with not performing the proposed activities. These findings are essential to align interprofessional education with education guidelines and public health policies in Brazil. Also, our results can provide useful information for the development of pedagogical guidelines for Multiprofessional Residency Programs in Brazil and in other low- and middle-income countries.
Detection of pharmaceutically active compounds in tap water samples by direct injection HPLC/MS-MS: A danger signal in deficiency in residue management.
Authors: Peregrina-Lucano Alejandro Aarón , Mendoza-Michel Judith , Rodríguez-Arreola Ariana , Peña-Velasco Gabriela 
Published: January 2024

Abstract

The growing and decelerated presence of pharmaceutically active compounds that affect networks of tap water is further studied due to the risks to the health public and the environment. Therefore, a direct injection-HPLC/MS-MS method is developed for the simultaneous determination of 16 active pharmaceutical compounds in tap water samples: amoxicillin, ampicillin, cephalexin, cefotaxime, cefuroxime, ciprofloxacin, clarithromycin, clindamycin, chloramphenicol, cyproterone, erythromycin, flutamide, spironolactone, sulfamethoxazole, tamoxifen, and trimethoprim. The implemented method obtained limits of detection (LOD) of 0.3 – 15 µg/L and quantification limits (LOQ) from 1.5 to 50 µg/L, recoveries percentages in the range of 70 - 125%, time retentions ≤ 2.1 min and allowed the analysis of 22 tap water samples where the highest concentrations corresponding to amoxicillin (147 µg/L) and ciprofloxacin (44 µg/L). The findings in this research could be a precedent for establishing safe levels of these compounds and increasing the standards for quality tap water.
Resilience Evaluation of Memristor-based PUF Against Machine Learning Attacks
Authors: Ibrahim Hebatallah M. , Skovorodnikov Heorhii , Alkhzaimi Hoda 
Published: January 2024

Abstract

Physical unclonable functions (PUFs) have emerged as a favorable hardware security primitive, they exploit the process variations to provide unique signatures. CMOS-based PUFs are the most popular type, however, most existing CMOS PUFs are found to be vulnerable to modeling attacks. Memristors leveraging nanotechnology fabrication processes and highly nonlinear behavior became an interesting alternative to the existing CMOS-based PUF technology. Memristor-based PUFs are emerging due to the inherent randomness at both the memristor level due to the cycle-to-cycle (C2C) programming variation of the device. Our study focuses on building a machine learning (ML) analysis and attack framework of tools on Cu/HfO2-x/p++Si memristor-based PUF (MR-PUF). Our objective is to test the resiliency of the security margins of the presented PUF using ML analysis tools. Our main contribution is a holistic study that focuses on attacking the randomness output resiliency based on building randomness predictors using Logistic Regression (LR), Support Vector Machine (SVM), Gaussian Mixture Models (GMM), K-means, K-means++, Random Forest, XGBoost and LSTM, within efficient time, and data complexity. Our results yield low accuracy and ROC results of within 0.49-0.52 and 0.49-0.52 respectively, indicating failure in predicting random data demonstrates efficient randomness prediction resiliency of the MR-PUF. The efficient time and data complexities of these attacks illustrated in this study are yielded to be linear and quadratic resulting in attack execution time in seconds and 5032 training samples combined with 2157 testing samples to verify the randomness of PUF.
Behavioral inhibition/activation systems and non-suicidal self-injury: the mediating role of problematic internet use in Chinese junior high school students
Authors: Wang Zhiyi , Liu Jintong , Ke Xiaoyan 
Published: January 2024

Abstract
Objective
Non-suicidal self-injury (NSSI) and problematic internet use (PIU) have become widespread issues among adolescents. Behavioral inhibition/activation systems (BIS/BAS) have been utilized to explain various psychopathology. However, the reports concentrating on how PIU plays a role in the development and maintenance of NSSI, and how different BIS/BAS subcomponents act on the process that PIU influences the development and maintenance of NSSI are relatively limited, particularly for Chinese adolescents. This study aimed to investigate the incidence of NSSI, the different roles of the BIS/BAS subcomponents in NSSI, and the role of PIU in the association between BIS/BAS and NSSI in Chinese junior high school students.
Methods
A total of 2384 Chinese junior high school students (\({M}_{age}\) = 13.66 years, SD = 0.982) were recruited by convenient sampling. They completed self-report questionnaires, including Adolescent Self-harm Behaviors Questionnaire, Behavioral Inhibition/Activation Systems Scales, and Young’s Internet Addiction Test. Correlation, stepwise regression, and mediation analysis were completed.
Results
The incidence of NSSI was 37.7% in Chinese junior high school students. After controlling for gender, BIS and BAS-Fun seeking displayed positive associations with NSSI, whereas BAS-Reward responsiveness showed negative associations. PIU mediated the relationships between BIS/BAS-Fun seeking/BAS-Reward responsiveness and NSSI to varying degrees. No significant association was found between BAS-Drive and NSSI as well as PIU.
Conclusion
The incidence of NSSI is relatively high among Chinese adolescents. This study clarifies the risk and protective factors for NSSI.
Purification of polysaccharide isolated from “Matthiola longipetala”: structure characterization and antioxidant activities
Authors: Eljoudi Souad , Hajji Mohamed , Li Suming , Bkhairia Intidhar , Petit Eddy , Darcos Vincent , Barkia Ahmed 
Published: January 2024

Abstract
Purpose: In this study, the polysaccharides isolated from Matthiola logipetala (PSMT) purified by DEAE-Sepharose chromatography. Tow fractions of polysaccharides, PSMT1 and PSMT2 were obtained.
Methods: The PSMT1 and PSMT2 structures and physicochemical proprieties were investigated using chemical and instrumental analysis, including Fourier transform infrared (FT-IR) spectroscopy, spectrum visible UV, nuclear magnetic spectroscopy (1H-NMR and 13C-NMR), X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM).
Results: The results of high-performance liquid chromatography (HPLC-MS) showed that the both purified polysaccharides PSMT1 and PSMT2 were mainly composed of rhamnose, arabinose, glucose and galactose in a molar percent in 39.69%, 29.59%, 8.81% and 21.89%, respectively for PSMT1 and 38.5%, 28.71%,15.1% and 17.676% respectively for PSMT2.The data of thermogravimetry analysis (TGA) and differential scanning calorimetry (DSC) indicated that PSMT1 and PSMT2 had relatively high thermal stability. The result of gel permeation chromatography (GPC) showed that PSMT1 and PSMT2 had a relative molecular weight of 9.779 kDa and 115.004 kDa respectively. Moreover, the in vitro antioxidant activities of PSMT were evaluated by DPPH free radical assay, ferrous iron–chelating, assay and total antioxidant activity. The experimental results showed that PSMT1 and PSMT2 exhibited an appreciable in vitro antioxidant potential.
Conclusion: Our results revealed that PSMT1 and PSMT2, polysaccharides purified from Matthiola longipetala could be novel active biomolecules with antioxidant proprieties, which promoting their application in the food and pharmaceutical fields.