bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing well‐being in the management of psoriasis: An expert recommendation
Authors: Sommer Rachel , Mrowietz Ulrich , Gaarn Du Jardin Kristian , Kasujee Ismail , Martini Elisa , Daudén Esteban , Fabbrocini Gabriella , Zink Alexander , Griffiths Christopher E. M. , Augustin Matthias 
Published: October 2023

AbstractPsoriasis causes detriment in a person's physical, mental and social health which impairs their quality of life (QoL). However, the current psoriasis management may not adequately address all relevant health domains. Since the goal of healthcare is to restore or maintain health, health outcomes should include all areas of the patient's overall health. Life satisfaction, QoL and patient well‐being are essential to a comprehensive approach to the disease. With the inclusion of more people‐centred policies, care of patients with psoriasis should evolve towards a holistic and integrated assessment of the disease impact, including subjective measures of well‐being in order to encompass all aspects of health. The main objective of this expert review is to give the concept of well‐being a place as an entity within the holistic therapeutic approach for patients with psoriasis. Identifying and defining common goals beyond the skin with the patient and testing them throughout the course of treatment will benefit and enhance treatment success. We propose a series of recommendations for application in clinical practice, providing tangible clinical guidance for implementing well‐being in the management of psoriasis. Among the recommendations are the need to initially listen to the patient, to know their level of empowerment or what they want to achieve, their preferences in decision making, the evaluation of not only the physical but also the emotional impact of the disease (well‐being), the definition of the aspects that can generate a cumulative deterioration of the disease throughout life, and a continuous assessment of the patient's preferences with the opinion of the expert clinician and the integration of the knowledge of external clinical evidence.
phylosem: A fast and simple R package for phylogenetic inference and trait imputation using phylogenetic structural equation models
Authors: Thorson James T. , van der Bijl Wouter 
Published: October 2023

Abstract
Phylogenetic comparative methods (PCMs) can be used to study evolutionary relationships and trade-offs among species traits. Analysts using PCM may want to (1) include latent variables, (2) estimate complex trait interdependencies, (3) predict missing trait values, (4) condition predicted traits upon phylogenetic correlations and (5) estimate relationships as slope parameters that can be compared with alternative regression methods. The Comprehensive R Archive Network (CRAN) includes well-documented software for phylogenetic linear models (phylolm), phylogenetic path analysis (phylopath), phylogenetic trait imputation (Rphylopars) and structural equation models (sem), but none of these can simultaneously accomplish all five analytical goals. We therefore introduce a new package phylosem for phylogenetic structural equation models (PSEM) and summarize features and interface. We also describe new analytical options, where users can specify any combination of Ornstein-Uhlenbeck, Pagel's-δ and Pagel's-λ transformations for species covariance. For the first time, we show that PSEM exactly reproduces estimates (and standard errors) for simplified cases that are feasible in sem, phylopath, phylolm and Rphylopars and demonstrate the approach by replicating a well-known case study involving trade-offs in plant energy budgets.
Abstract
We develop a new R-package phylosem that provides a simple interface for phylogenetic structural equation models. We identify and visualize five desirable features (coloured ellipses and labelled using matching coloured boxes), and note how four existing R-packages (grey boxes) each address different combinations of these five features. In this paper, we then outline how phylosem incorporates all five features.
Thiamin dynamics during the adult life cycle of Atlantic salmon (Salmo salar)
Authors: Todisco Vittoria , Fridolfsson Emil , Axén Charlotte , Dahlgren Elin , Ejsmond Maciej J. , Hauber Marc M. , Hindar Kjetil , Tibblin Petter , Zöttl Markus , Söderberg Linda , Hylander Samuel 
Published: October 2023

AbstractThiamin is an essential water‐soluble B vitamin known for its wide range of metabolic functions and antioxidant properties. Over the past decades, reproductive failures induced by thiamin deficiency have been observed in several salmonid species worldwide, but it is unclear why this micronutrient deficiency arises. Few studies have compared thiamin concentrations in systems of salmonid populations with or without documented thiamin deficiency. Moreover, it is not well known whether and how thiamin concentration changes during the marine feeding phase and the spawning migration. Therefore, samples of Atlantic salmon (Salmo salar) were collected when actively feeding in the open Baltic Sea, after the sea migration to natal rivers, after river migration, and during the spawning period. To compare populations of Baltic salmon with systems without documented thiamin deficiency, a population of landlocked salmon located in Lake Vänern (Sweden) was sampled as well as salmon from Norwegian rivers draining into the North Atlantic Ocean. Results showed the highest mean thiamin concentrations in Lake Vänern salmon, followed by North Atlantic, and the lowest in Baltic populations. Therefore, salmon in the Baltic Sea seem to be consistently more constrained by thiamin than those in other systems. Condition factor and body length had little to no effect on thiamin concentrations in all systems, suggesting that there is no relation between the body condition of salmon and thiamin deficiency. In our large spatiotemporal comparison of salmon populations, thiamin concentrations declined toward spawning in all studied systems, suggesting that the reduction in thiamin concentration arises as a natural consequence of starvation rather than to be related to thiamin deficiency in the system. These results suggest that factors affecting accumulation during the marine feeding phase are key for understanding the thiamin deficiency in salmonids.
Ultrafast extraction of cold brew coffee in a planetary rotating bed reactor: A kinetic study on the pushback effect
Authors: von Heynitz Christian , Ohlmann Kilian , Schmieder Benedikt , Hofmann Thomas , Glas Karl 
Published: October 2023

AbstractGiven the rising demand for cold brew coffee, innovative approaches are required to address the present difficulties in its production. This motivates the consideration of the planetary rotating bed reactor (PRBR) as a solid–liquid extraction technology. The PRBR consists of cylindrical mesh chambers that contain the solid phase and move in two superimposed rotations. This motion pattern enhances mass transfer through alternating radial forces: the pushback effect (PBE). To evaluate the utility of the PRBR and the role of PBE, we investigated the kinetics and energy demand of cold brew coffee extraction. For this purpose, we varied rotational speeds and PBE conditions in a 1 L lab‐scale reactor. Kinetics was determined by in‐line monitoring of electrical conductivity correlated with the eluate's weight‐based total dissolved solids and caffeine by high‐performance liquid chromatography. Energy consumption was derived from strain gauge torque measurements. Our findings reveal that saturation of the extraction rate with respect to the rotational speed is evident both with and without PBE. However, PBE significantly reduces extraction time by 75% while requiring 60% less mechanical energy. The fastest conditions probed 95% of the maximum extraction yield within 12 s, effectively being >99% faster than static immersion. We believe these findings, along with further procedural advantages, qualify the PRBR as a viable technology for cold brew coffee production.Practical ApplicationsThe relevance of an economical and sustainable preparation of cold brew coffee extends from the industrial to the gastronomic to the domestic environment. Challenges and limitations relate to process time, particle separation, product and extraction yield, and taste problems due to over‐extraction. The planetary rotating bed reactor (PRBR) promises to address all these issues by combining extraction and separation in a simultaneous and ultrafast process. The present study confirms the superiority of PRBR's action mechanisms in terms of rapidity and energetic efficiency for extraction. Due to the excellent scalability of both the design and the physical effect, the PRBR is intended for large‐scale production of ready‐to‐drink products and local production in coffee shops or private households. By modifying the particle feed, even continuous operation is conceivable. Further applications are, for example, dry‐hopping of beer, fast‐aging of spirits, and preparation of various liquid foods.
Embodied carbon quantification of luminaires using life cycle assessment and CIBSE TM65 methodologies: A comparison case study
Authors: Mazzei Irene , Saint Ruth , Kay Alistair , Pomponi Francesco 
Published: October 2023

AbstractThe European legislative landscape on sustainability is steadily growing to meet objectives to reach net zero targets by mid‐century. In this context, companies and manufacturers may soon be legally required to provide quantification of the environmental impact of their products and services. A key challenge is applying a consistent and robust methodology that ensures comparability between assessments made by different companies, as there is still fragmentation among environmental impact reporting methodologies. The objective of this study is to analyze and compare the results of two different methodologies for the calculation of the embodied carbon in lighting products using the cradle‐to‐grave approach. One is the globally known life cycle assessment (LCA) method, and the other is Chartered Institution of Building Services Engineers Technical Memorandum 65's (TM65) mid‐level calculation methodology, which has been specifically tailored to building services. The two were applied to six different luminaires to evaluate their differences. Results show that the values of the embodied carbon calculated with TM65 are higher than those calculated with LCA and that the weight of the products plays a crucial role in creating discrepancies between the two methodologies.
Understanding language and cognition after brain surgery – Tumour grade, fine‐grained assessment tools and, most of all, individualized approach
Authors: Gasa‐Roqué Anna , Rofes Adrià , Simó Marta , Juncadella Montserrat , Rico Pons Imma , Camins Angels , Gabarrós Andreu , Rodríguez‐Fornells Antoni , Sierpowska Joanna 
Published: October 2023

AbstractCognitive performance influences the quality of life and survival of people with glioma. Thus, a detailed neuropsychological and language evaluation is essential. In this work, we tested if an analysis of errors in naming can indicate semantic and/or phonological impairments in 87 awake brain surgery patients. Secondly, we explored how language and cognition change after brain tumour resection. Finally, we checked if low‐tumour grade had a protective effect on cognition. Our results indicated that naming errors can be useful to monitor semantic and phonological processing, as their number correlated with scores on tasks developed by our team for testing these domains. Secondly, we showed that – although an analysis at a whole group level indicates a decline in language functions – significantly more individual patients improve or remain stable when compared to the ones who declined. Finally, we observed that having LGG, when compared with HGG, favours patients' outcome after surgery, most probably due to brain plasticity mechanisms. We provide new evidence of the importance of applying a broader neuropsychological assessment and an analysis of naming errors in patients with glioma. Our approach may potentially ensure better detection of cognitive deficits and contribute to better postoperative outcomes. Our study also shows that an individualized approach in post‐surgical follow‐ups can reveal reassuring results showing that significantly more patients remain stable or improve and can be a promising avenue for similar reports. Finally, the study captures that plasticity mechanisms may act as protective in LGG versus HGG after surgery.
Toward facial rejuvenation; A clinical trial to assess the efficacy of nano fat grafting on wrinkles
Authors: Akbari Farzaneh , Hadibarhaghtalab Maryam , Parvar Seyedeh Yasamin , Dehghani Sara , Namazi Mohammad Reza 
Published: October 2023

AbstractIntroductionWith increasing age, patients' facial volume decrease. For this reason, nano fat grafting has recently gained popularity as adjunctive treatment to facial rejuvenation procedures. However, few quantitative studies have been conducted to investigate the impact of nano fat on facial wrinkles.AimsIn the present study, authors aim to investigate the therapeutic effect of intradermal injection of nano fat on fine facial wrinkles and assess their changes over 7 months of follow‐up.MethodsIn this randomized trial, 15 patients with fine facial wrinkles were enrolled. The fat was harvested from the abdomen and processed into nano fat. Nano fat was injected into the facial wrinkles intradermally with a needle of 27 gauge. The patients were evaluated before and 7 months postinjection utilizing Visio face 1000D (CK electronic, manufactured in Germany); and four parameters of wrinkles (area, volume, depth, and percent area) were evaluated before and after the nano fat injection.ResultsOur evaluation with Visio face showed that nano fat injection was significantly reduced the volume, area, depth, and percent area of wrinkles after 7 months of follow‐up without serious long‐lasting adverse effects. Moreover, wrinkles with higher percent area, depth and volume loss show greater improvement after the treatment. Our results also indicate that males and females equally benefit from this treatment except for the percent area parameter that was improved more significantly in male patients.ConclusionOur study showed that intradermal injection of nano fat significantly decreases the volume, area, depth, and percent area of fine facial wrinkles. Further quantitative studies with control groups and larger sample sizes are required.
Keeping us young? Grandchild caregiving and older adults' cognitive functioning
Authors: Caputo Jennifer , Cagney Kathleen A. , Waite Linda 
Published: October 2023

AbstractObjectiveThis study investigates longitudinal associations between providing care to grandchildren and cognitive functioning. It also examines heterogeneity in these relationships.BackgroundGrandchild caregiving may support older adults' cognitive functioning by providing social engagement and emotional meaning. However, studies caution that time‐intensive or custodial grandchild caregiving can take a toll on grandparents. The cognitive health implications of grandchild caregiving may thus depend on contexts including time spent providing care and living arrangements. They may also vary across sociodemographic groups and have greater effects on older adults who are more vulnerable to cognitive decline.MethodData came from the 1998–2016 waves of the Health and Retirement Study (HRS) and represented over 11,000 US adults aged 50+. Using linear growth curve and dynamic panel models, the analysis explored relationships between level of grandchild care and cognitive functioning over time and across sociodemographic, family, work, and health characteristics.ResultsThose providing 100–199, 200–499, or 500+ h of care to grandchildren had better cognitive functioning than non‐caregivers regardless of whether they lived with grandchildren. Positive links between grandchild caregiving and cognition were stronger for lower income, non‐working, and unpartnered adults and grew with age and functional limitations.ConclusionThese findings suggest that providing care to minor grandchildren may help support cognitive functioning as adults age. They also support the hypothesis that more vulnerable or isolated groups of older adults may benefit the most from grandchild caregiving.
Gelatin methacryloyl hydrogel with and without dental pulp stem cells for TMJ regeneration: An in vivo study in rabbits
Authors: Monteiro Joao Luiz , Takusagawa Toru , Sampaio Gerhilde C. , He Helen , de Oliveira e Silva Emanuel D. , Vasconcelos Belmiro C. E. , McCain Joseph P. , Redmond Robert W. , Randolph Mark A. , Guastaldi Fernando P. S. 
Published: October 2023

AbstractBackgroundIn the last decade, tissue‐engineering strategies for regenerating the temporomandibular joint (TMJ) have been investigated. This may be a promising strategy for the minimally invasive restoration of joint integrity.ObjectivesTo evaluate whether dental pulp stem cells (DPSCs) loaded in a light‐occured hydrogel made of gelatin methacryloyl (GelMA) enhance the regeneration of osteochondral defects in the rabbit TMJ.Materials and MethodsDefects were filled with GelMA alone (control group; n = 4) or filled with GelMA loaded with rabbit DPSCs (experimental group; n = 4), In one group, the TMJ capsule was opened without creating a defect (sham group; n = 2). The following micro‐CT parameters were analysed: bone volume to total volume ratio (BV/TV%) and bone mineral density (BMD). Histological evaluation was performed to assess cartilage regeneration features. A semi‐quantitative scoring system was also used to evaluate the defects.ResultsAll groups had no statistical difference regarding the micro‐CT parameters. The highest mean healing score was found for the experimental group. After 4 weeks, there were no signs of hydrogel in either group or no signs of inflammation in the adjacent tissues. The tissue formed in the defect was dense fibrous connective tissue.ConclusionAdding DPSCs to GelMA did not provide a regenerative enhancement in TMJ osteochondral defects. This resulted in similar micro‐CT parameters after 4 weeks of healing, with improved signs of subchondral bone regeneration but no cartilage regeneration.
Percutaneous shunt vessel embolisation with Amplatzer vascular plugs II and IV in the treatment of dogs with splenophrenic shunts: four cases (2019‐2022)
Authors: Kawamura Y. , Itou H. , Kida A. , Sunakawa H. , Suzuki M. , Kawamura K. 
Published: October 2023

ObjectivesTo describe the treatment of four dogs with splenophrenic shunts using percutaneous shunting vessel embolisation with Amplatzer vascular plugs II and IV and provide information on their clinical outcomes.Materials and MethodsDogs with splenophrenic shunts treated at a veterinary hospital from January 2019 to December 2022 were identified through a medical record search.ResultsSix dogs with splenophrenic shunts were identified. Two dogs were excluded because they were treated with laparoscopic surgery. Four underwent percutaneous shunting vessel embolization with Amplatzer vascular plugs and were included in the case series. A sheath was placed in the left external jugular vein and a balloon catheter was advanced to the shunting vessel under fluoroscopy. Portal vein pressure was confirmed to be within an acceptable range during temporary balloon occlusion. Based on preoperative CT angiography and intraoperative contrast examination, Amplatzer vascular plugs II were selected for two dogs and IV were selected for two dogs. Under fluoroscopy, the plug was deployed into the shunting vessel, and angiography confirmed occlusion. In all cases, the increase in portal pressure after temporary occlusion was within the acceptable range, and complete occlusion of blood flow was possible with a single plug. There were no major procedure‐related complications. No dogs developed post‐ligation seizures or signs of portal hypertension. In addition, improvements in ammonia values were observed in all cases.Clinical SignificancePercutaneous splenophrenic shunt embolisation using Amplatzer vascular plugs II and IV is technically feasible in dogs, and assessed by intra‐procedure angiography, a single plug completely obstructed blood flow in all dogs. Based on the literature search, this is the first report describing Amplatzer vascular plugs for the treatment of splenophrenic shunts.
Adverse effects of trazodone in dogs on primary hemostasis and electrocardiogram: A single‐blinded placebo‐controlled crossover study
Authors: Benjamin Eduardo J. , Nelson O. Lynne , Baumwart Ryan , Haines Jillian 
Published: October 2023

AbstractBackgroundTrazodone is a serotonin antagonist/reuptake inhibitor medication commonly used for anxiety in dogs. Therapy with selective serotonin reuptake inhibitors in humans is associated with bleeding disorders and increased arrhythmogenesis.Hypothesis/ObjectivesTo evaluate markers of primary hemostasis and corrected QT (cQT) interval in dogs before and after oral administration of standard dosages of trazodone or placebo.AnimalsFifteen apparently healthy, client‐owned dogs.MethodsA single‐blinded, randomized placebo‐controlled crossover study was performed. Dogs were administered trazodone (5 to 7.5 mg/kg PO Q12h) or placebo. [Correction added after first online publication on 14 October 2023. In the abstract (methods) section (57.5 mg/kg PO Q12h) changed as (5 to 7.5 mg/kg PO Q12h).] Buccal mucosal bleeding time (BMBT), platelet count, platelet aggregation via Plateletworks, PFA‐100 closure time and cQT interval were measured. A Shapiro‐Wilk test was performed followed by either a paired t test or a Wilcoxon signed‐rank test.ResultsNo significant difference was detected in the BMBT, PFA‐100 closure times, platelet counts, and cQT interval between trazodone or placebo. However, using Plateletworks, there was a significant decrease in platelet aggregation after administration of trazodone (95%; 81‐97 vs 62%; 39‐89, P = .002) and not placebo (95%; 81‐97 vs 91%; 81‐96, P = .21).ConclusionsIt is unknown if this represents a clinically relevant change or if dogs with preexisting impairment in primary hemostasis or receiving higher dosages or longer durations of trazodone could have a more substantial change in hemostatic variables.
The phagocytosis oxidase/Bem1p domain‐containing protein PB1CP negatively regulates the NADPH oxidase RBOHD in plant immunity
Authors: Goto Yukihisa , Maki Noriko , Sklenar Jan , Derbyshire Paul , Menke Frank L. H. , Zipfel Cyril , Kadota Yasuhiro , Shirasu Ken 
Published: October 2023

Summary
Perception of pathogen‐associated molecular patterns (PAMPs) by surface‐localized pattern recognition receptors activates RESPIRATORY BURST OXIDASE HOMOLOG D (RBOHD) through direct phosphorylation by BOTRYTIS‐INDUCED KINASE 1 (BIK1) and induces the production of reactive oxygen species (ROS). RBOHD activity must be tightly controlled to avoid the detrimental effects of ROS, but little is known about RBOHD downregulation.
To understand the regulation of RBOHD, we used co‐immunoprecipitation of RBOHD with mass spectrometry analysis and identified PHAGOCYTOSIS OXIDASE/BEM1P (PB1) DOMAIN‐CONTAINING PROTEIN (PB1CP).
PB1CP negatively regulates RBOHD and the resistance against the fungal pathogen Colletotrichum higginsianum. PB1CP competes with BIK1 for binding to RBOHD in vitro. Furthermore, PAMP treatment enhances the PB1CP‐RBOHD interaction, thereby leading to the dissociation of phosphorylated BIK1 from RBOHD in vivo. PB1CP localizes at the cell periphery and PAMP treatment induces relocalization of PB1CP and RBOHD to the same small endomembrane compartments. Additionally, overexpression of PB1CP in Arabidopsis leads to a reduction in the abundance of RBOHD protein, suggesting the possible involvement of PB1CP in RBOHD endocytosis.
We found PB1CP, a novel negative regulator of RBOHD, and revealed its possible regulatory mechanisms involving the removal of phosphorylated BIK1 from RBOHD and the promotion of RBOHD endocytosis.