bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Healthcare Use Following COVID-19 Vaccination Among Adults With Rheumatoid Arthritis: A Population-Based Self-Controlled Case Series Analysis
Authors: Lee Jennifer J.Y. , Bernatsky Sasha , Kwong Jeffrey C. , Li Qing , Kwok Timothy S.H. , Widdifield Jessica 
Published: October 2023

ObjectiveTo determine if coronavirus disease 2019 (COVID-19) vaccines were associated with adverse events of special interest (AESIs) and healthcare use among adults with rheumatoid arthritis (RA).MethodsAmong adults with RA who received at least 1 COVID-19 vaccine, a self-controlled case series (SCCS) analysis was conducted to evaluate relative incidence (RI) rates of AESIs (Bell palsy, idiopathic thrombocytopenia, acute disseminated encephalomyelitis, pericarditis/myocarditis, Guillain-Barré syndrome, transverse myelitis, myocardial infarction, anaphylaxis, stroke, deep vein thrombosis, pulmonary embolism, narcolepsy, appendicitis, and disseminated intravascular coagulation) in any 21-day period following vaccination compared to control periods. Secondary outcomes included emergency department (ED) visits, hospitalizations, and rheumatology visits. A matched non-RA comparator group was created and a separate SCCS analysis was conducted. RI ratios (RIRs) were used to compare RA and non-RA groups.ResultsAmong 123,466 patients with RA and 493,864 comparators, the majority received mRNA vaccines. For patients with RA, relative to control periods, AESIs were not increased. ED visits increased after dose 2 (RI 1.06, 95% CI 1.03-1.10) and decreased after dose 3 (RI 0.93, 95% CI 0.89-0.96). Hospitalizations were lower after the first (RI 0.83, 95% CI 0.78-0.88), second (RI 0.86, 95% CI 0.81-0.92), and third (RI 0.89, 95% CI 0.83-0.95) doses. Rheumatology visits increased after dose 1 (RI 1.08, 95% CI 1.07-1.10), and decreased after doses 2 and 3. Relative to comparators, patients with RA had a higher AESI risk after dose 3 (RIR 1.28, 95% CI 1.05-1.56). Patients with RA experienced fewer ED visits (RIR 0.73, 95% CI 0.58-0.90) and hospitalizations (RIR 0.52, 95% CI 0.36-0.75) after dose 4.ConclusionCOVID-19 vaccines in patients with RA were not associated with an increase in AESI risk or healthcare use after every dose.
Interprofessional Telerounds in a Pediatric Intensive Care Unit: A Quality Improvement Project
Authors: Shawley Emily , Whiteman Kimberly 
Published: October 2023

Background
Family-centered rounds are standard practice in pediatrics. However, some parents of children in the pediatric intensive care unit cannot attend rounds.

Local Problem
A 36-bed academic, tertiary care pediatric hospital implemented telerounds during the COVID-19 pandemic. After visiting restrictions were lifted, nurses were interested in continuing telerounds for families who could not attend daily rounds. The aim of this evidence-based quality improvement project was to develop a standardized, family-centered telerounding process that satisfied parents, nurses, and physicians.

Methods
Nurses offered telerounds to pediatric intensive care unit family members who could not attend rounds. Families received a unique link to telerounds using a secure connection. Nurses completed electronic satisfaction surveys after each session; physicians completed surveys at the end of their weeklong pediatric intensive care unit rotation; families received surveys at the end of the pediatric intensive care unit stay.

Results
Twenty families qualified for telerounds; 16 families completed sessions. Enrolled patients and families participated in 93 telerounding events. Nine family members (56%) returned satisfaction surveys revealing an overall satisfaction level of 9.9 out of 10. Thirty nurses reported an overall satisfaction level of 8.8 out of 10. Eleven physicians reported a mean satisfaction level of 8.8 out of 10.

Conclusions
This project demonstrated that a standardized process of secure telerounding was feasible in a pediatric intensive care unit. Families, nurses, and physicians reported satisfaction with the process. Telerounds can be implemented without considerable inconvenience to staff and enable continuation of family-centered care when parents are absent from the hospital.
Use of Telestroke to Improve Access to Care for Rural Patients With Stroke Symptoms
Authors: Hendrickx Lori , Kuznia Chelsey , Maneval Lindsey 
Published: October 2023

Background
Cerebrovascular accident, or stroke, is a common cause of death or disability. Timely diagnosis and intervention are critical for improving survival rates and reducing the long-term effects of stroke. For patients with ischemic stroke, thrombolytic drugs and endovascular intervention are time-sensitive treatment options.

Local Problem
Patients living in rural areas often do not have access to rapid consultation with specialized neurologic teams for diagnosis and treatment of stroke. The use of telemedicine in the form of a telestroke consultation can improve timely diagnosis and treatment for rural patients exhibiting stroke symptoms.

Methods
A telestroke program was implemented in the upper Midwest. A team of 4 interventional neurologists provided telestroke consultation to a comprehensive stroke center and 5 other acute stroke–ready rural hospitals.

Results
A tiered stroke alert algorithm and telestroke workflow chart were developed to help health care professionals at rural sites determine eligibility for telestroke consultation. A teleneurologist connected with the originating site, and the National Institutes of Health Stroke Scale could be completed remotely with assistance from the originating site. Telestroke has increased the percentage of patients receiving thrombolytics in less than 60 minutes, and door-to-needle time has decreased.

Conclusion
Rural patients with stroke symptoms may experience a delay in care or stroke diagnosis due to distance to specialized neurologic services. Telestroke consultation is a successful method for timely diagnosis of stroke and recommendation for treatment.
Implementation of a Pressure Injury Prevention Protocol for Intensive Care Unit Patients Undergoing Prone Positioning
Authors: McFee Kelly , Murdoch Julie M. , Spitzer Mandy 
Published: October 2023

Background
Pressure injuries remain the most common hospital-acquired condition, according to the Agency for Healthcare Research and Quality. Patients hospitalized with COVID-19 are at especially high risk for pressure injuries, including those related to medical devices, because of their lower tissue tolerance, prolonged intubation, and common treatment with prone positioning.

Local Problem
The COVID-19 pandemic brought an increased incidence of hospital-acquired pressure injury. A 350-bed hospital in St. Joseph, Missouri, recognized that an intervention to lower the risk of pressure injury for these patients was needed.

Methods
A quality improvement project was initiated to reduce the incidence of pressure injuries in patients with COVID-19 in the intensive care unit. A protocol was implemented for patients with COVID-19 undergoing prone positioning that included the use of dressing packets. The incidence of hospital-acquired pressure injury during the 1-year periods before and after implementation of the protocol were determined.

Results
Before implementation of the new protocol, 18 of 155 intensive care unit patients with COVID-19 who were placed in a prone position (11.6%) experienced a hospital-acquired pressure or medical device–related injury, compared with 3 of 111 patients (2.7%) after protocol implementation, a reduction of 76.7% (P = .008).

Conclusions
The risk of hospital-acquired pressure injuries can be reduced with additional education and the use of appropriate products and protocols. All patients who undergo prone positioning, regardless of diagnosis, may benefit from implementation of a pressure injury prevention protocol that includes the use of dressing packets.
Indian Endodontic Society: Position statement for deep caries management and vital pulp therapy procedures
Authors: Nawal Ruchika Roongta , Logani Ajay , Sangwan Pankaj , Ballal N Vasudev , Gopikrishna Velayutham 
Published: October 2023

ABSTRACT
This position statement on Vital Pulp Therapy (VPT) procedures, endorsed by the Indian Endodontic Society (IES), aims to provide a comprehensive perspective on the management of deep caries and exposed pulp within the realm of endodontic practice. VPT serves as the cornerstone of modern endodontics, particularly with advancements in biomaterials and regenerative methods. Its primary goal is to preserve the vitality of the dental pulp while simultaneously promoting the overall health of the tooth and periapical structures. In the diverse and dynamic landscape of Indian dentistry, the IES recognizes the need for a position statement tailored to the unique needs and challenges encountered by dental practitioners in India. This position statement presents evidence-based recommendations on VPT, considering not only international perspectives from reputed international organizations, but also the distinct factors influencing dental care in India. Drawing upon the collective expertise of the expert committee, this statement addresses key aspects of VPT, including patient selection, accurate diagnosis, effective treatment techniques, and follow-up protocols. While conventional endodontic therapy remains important, IES emphasizes the significance of VPT in well-selected cases. The statement also addresses areas of potential conflict, identifies avenues for future research, and presents the current status based on the best available scientific evidence. By providing a comprehensive overview of VPT, this position statement aims to serve as a valuable guide for dental practitioners, educators, and researchers, fostering optimal patient care and advancing the field of endodontics in India through evidence-based practice and continuous learning.
Comparative evaluation of the effectiveness of XP-endo Finisher and passive ultrasonic activation on dentinal tubule penetration of irrigation solution: A confocal laser scanning microscopy study
Authors: Rao Ajay Singh , Bhor Shreya , Shah Unnati 
Published: October 2023

ABSTRACT

Aim:
The aim of this in vitro study was to comparatively evaluate the effectiveness of XP-endo Finisher and passive ultrasonic (PU) activation on dentinal tubule penetration of irrigation solution: A confocal laser scanning microscopy study.

Materials and Methods:
Forty extracted single-rooted human mandibular canines and premolars were instrumented up to size 40/06 taper and randomly divided into 2 groups (n = 20) based on the activation technique of final irrigation solution into Group A: PU activation and Group B: XP-endo Finisher activation. In each group, 5 ml of 5% NaOCl labeled with fluorescent dye was used during activation as the final irrigation solution. Specimens were sectioned at 2, 5, and 8 mm from the apex and examined under confocal microscope to calculate the dentinal tubule penetration area. Data were analyzed using Tukey’s post hoc tests (P = 0.05).

Results:
PU activation exhibited a significantly higher penetration area than XP-endo Finisher activation (P < 0.05). In addition, at coronal, middle, and apical thirds, all regions of PU activation had significantly higher penetration than XP-endo Finisher activation. Statistically significant differences were found between each root canal third (coronal > middle > apical) (P < 0.001).

Conclusion:
The PU activation is more effective than XP-endo Finisher in terms of irrigant penetration into the dentinal tubules.
Evaluation of chelating effect of chitosan as intracanal lubricant and an irrigant on smear layer removal – An in-vitro scanning electron microscope study
Authors: Jyotsnanjali Thati , Ranjini M. A. , Kumar G. R. Krishna , Swapna D. V. , Joshi S. N. , Nadig Roopa R. 
Published: October 2023

ABSTRACT

Aim:
The aim of the study is to evaluate the chelating effect of chitosan as intracanal lubricant and an irrigant on smear layer removal.

Objective:
The objective of the study is to compare the effectiveness of smear layer removal with chitosan gel and ethylenediaminetetraacetic acid (EDTA) gel as an intracanal lubricant and to evaluate the cumulative outcome of chitosan gel and final rinse on smear layer removal compared to EDTA gel and solution.

Materials and Methods:
Forty single-rooted extracted human premolars were decoronated to a standard length. Cleaning and shaping were carried out using Mtwo rotary instrument and 3% sodium hypochlorite irrigant. Prepared specimens were divided into four equal groups (n = 10). In first two groups, 17% EDTA gel lubricant was used during instrumentation and final rinsing was carried out with 2 ml saline in one group and 2 ml 17% EDTA solution for 1 min in the other. In other two groups, 0.2% chitosan gel was used as lubricant, and final rinsing was carried out with 2 ml saline in one group and 2 ml 0.2% chitosan solution for 3 min in the other group. All the samples were then longitudinally sectioned which were then evaluated under scanning electron microscope for smear layer removal in three levels, i.e., cervical, middle, and apical third.

Statistical Analysis Used:
Comparison of mean smear layer scores in the coronal middle and apical thirds of the root canals between four study groups was done using Kruskal–Wallis test followed by Mann–Whitney Post hoc analysis for intergroup comparison with P < 0.05 as statistically significant.

Results:
In coronal, middle, and apical third sections of root canal, EDTA combination and chitosan combination groups demonstrated statistically significant smear layer removal compared to EDTA gel alone and chitosan gel alone groups. Among the gel groups, chitosan gel has shown a significant smear layer removal ability than EDTA gel.

Conclusions:
0.2% chitosan gel lubricant and final rinse solution combination showed comparable smear layer removal as that of 17% EDTA gel lubricant and final rinse. While 0.2% chitosan gel lubricant with saline final rinse showed similar smear layer removal ability like 17% EDTA gel with saline final rinse in coronal and middle third, it performed better than EDTA gel in the crucial apical one-third of root canal.
Evaluation of antimicrobial efficacy of 1% phytic acid incorporated with 0.2% chitosan nanoparticles against Enterococcus faecalis: An in vitro study
Authors: Halkai Rahul , Halkai Kiran R. , Mahveen Syeda Uzma , Zakaullah Syed , Ishaq S. Syed , Firdous Javeria 
Published: October 2023

ABSTRACT

Aim:
The aim of the study was to evaluate the antimicrobial activity of 1% phytic acid and ethylenediaminetetraacetic acid (EDTA) incorporated with 0.2% of chitosan nanoparticles (Csnps) against Enterococcus faecalis (E. faecalis) by agar diffusion and biofilm model.

Materials and Methods:
Antimicrobial efficacy was evaluated in two stages: (i) agar well-diffusion method and (ii) biofilm model. E faecalis (American Type Culture Collection 29212) strain was subcultured and grown on the blood agar plates, followed by placement of test solutions in punched holes (5 mm diameter) and incubated for 24 h at 37°C as follows (n = 10): Group 1: normal saline (control), Group 2: EDTA, Group 3: EDTA +0.2% Csnps, Group 4: 1% phytic acid, and Group 5: 1% phytic acid + 0.2% Csnps followed by measurement of inhibition zone. For biofilm model, standardized dentin blocks were prepared from fifty human-extracted single-rooted premolars and sterilized and contaminated for 2 weeks by transferring 50 μl of bacterial inoculum to sterilized test tubes containing 1 mL of Mueller–Hinton agar broth (MHA) with alternate day replenishment of the broth. The specimens were cleaned and subjected to test solutions as mentioned above. Serial decimal dilutions were prepared, followed by inoculation on MHA plates and incubation for 24 h, accompanied by counting of the colonies per milliliter (colony-forming unit per milliliter). Results were statistically analyzed using one-way analysis of variance and Post hoc Tukey’s tests (P < 0.05).

Results:
Phytic acid incorporated with Csnps exhibited a greater zone of inhibition and least colony count against E. faecalis biofilm compared to all groups.

Conclusion:
Combination of Csnps and phytic acid exhibits effective antimicrobial activity against E. faecalis.
Comparative evaluation of the effectiveness of calcium silicate-based materials with or without platelet-rich fibrin as a pulpotomy medicament in human permanent teeth with irreversible pulpitis: A randomized clinical trial
Authors: Chhabra Swati , Kukreja Navneet , Sachdeva Surinder , Thakur Anamika , Trivedi Shivangi , Bhardwaj Anuj 
Published: October 2023

ABSTRACT

Aim:
This randomized clinical trial aimed to compare the effectiveness of mineral trioxide aggregate (MTA), Biodentine, platelet-rich fibrin (PRF) with MTA, and PRF with Biodentine as pulpotomy medicament in the permanent molars with symptomatic irreversible pulpitis clinically and radiographically.

Materials and Methods:
Sixty permanent first molars with a carious exposed tooth showing signs and symptoms of irreversible pulpitis with caries extending >2/3rd of dentin, but no signs of pulpal necrosis, were randomly allocated in four groups, and full pulpotomy was performed using MTA, Biodentine, PRF with MTA, and PRF with Biodentine as pulpotomy agents. The clinical and radiographic assessment was done after 24 h, 3 months, 6 months, and 9 months postoperatively. Nonparametric tests, including Kruskal–Wallis, Friedman test, and Chi-square test, were used for repeated measures among the biomaterials. For pair-wise comparison of subgroups, the Wilcoxon sum-rank test was used.

Results:
The clinical success rate was 90.5% at a 9-month interval. There was a nonsignificant result among all the groups (P < 0.05), and all agents were equally effective in providing pain relief at all the intervals tested. No significant difference was observed between the radiographic success rates observed among the groups (P = 0.089 at 6 months and P = 0.095 at 9 months).

Conclusion:
Pulpotomy dressing agents used proved to be a success in mature permanent teeth with carious exposure with clinical signs and symptoms of irreversible pulpitis.
Comparative analysis of postendodontic pain using multiple versus single rotary file systems in single-visit endodontics: A randomized clinical trial
Authors: Patel Nishtha K , Attur Kailas , Bagda Kamal P , Yagnik Krushnangi , Doshi Prerak , Oak Anjali 
Published: October 2023

ABSTRACT

Aim:
The aim of this study was to compare and evaluate the severity of PEP using ProTaper Gold (PTG), ProTaper Next (PTN), and F-One rotary files in single-visit endodontic (SVE) treatment.

Materials and Methods:
In a randomized factorial clinical trial, 150 patients indicated for endodontic treatment in maxillary molars and mandibular molars were selected. They were separated into three groups: Group 1 (PTG), Group 2 (PTN), and Group 3 (F-One). SVE treatment was done under local anesthesia. The intensity of PEP was assessed using the Visual Analog Scale (VAS) after 24, 48, 72 h, and 1 week. Finally, the data were tabulated and statistically analyzed using SPSS software. VAS was analyzed using analysis of variance test with Scheffe’s post hoc test.

Results:
PEP was less in Group 3 (F-One) and Group 2 (PTN) as compared to Group 1 (PTG) at 24.48 h which is statistically significant (P < 0.05), whereas the difference between PTN and F-One was statistically insignificant.

Conclusion:
All file systems showed PEP, but the intensity of pain was minimum in F-One single rotary file system followed by PTN and PTG Multi-file systems.
Pengaruh Lama Fermentasi Tumpi Jagung Menggunakan Yakult Sebagai Alternatif Pengolahan Pakan Ternak Ruminansia
Authors: Yahya Rumjayadi , Irwan Muh , M Armayani 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui nilai nutrisi tumpi jagung yang di fermentasi menggunakan yakult. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) terdiri dari 4 perlakuan 5 ulangan. Faktor yang diteliti adalah faktor perlakuan fermentasi tumpi jagung menggunakan yakult, “P” terdiri dari 4 taraf P0 = tumpi jagung tanpa fermentasi (Kontrol), P1 = fermentasi tumpi jagung 14 hari, P2 = fermentasi tumpi jagung 21 hari, P3 = fermentasi tumpi jagung 28 hari. Parameter yang diamati adalah protein kasar (%), serat kasar (%), lemak kasar (%), kadar air (%), kadar abu(%). Perlakuan fermentasi dengan menggunakan yakult terhadap nutrisi tumpi jagung menunjukkan sangat berpengaruh nyata pada pengamatan protein kasar (%), lemak kasar (%), lemak kasar(%). Berbeda sangat nyata pada pengamatan kadar abu dan kadar air (%). Jadi kesimpulan dari penelitian ini adalah tumpi jagung fermentasi yang dapat di manfaatkan sebagi pakan alternatif ternak ruminansia yaitu dengan masa fermentasi 21 hari.
Dampak Sosial dan Lingkungan Terhadap Keberadaan Peternakan Sapi Potong (Studi Kasus CV. Suka Maju)
Authors: Said Muh , Nugraha Angga , Mansur Musdalifa 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui dampak sosial lingkungan masyarakat terhadap adanya usaha ternak potong CV.Suka Maju dan untuk mengetahui upaya yang dilakukan masyarakat dan pemilik usaha dalam menanggulangi dampak negatif sosial terhadap lingkungan akibat adanya usaha ternak sapi potong CV.Suka Maju di Kelurahan Massepe, Kecamatan Tellu Limpoe Kabupaten Sidenreng Rappang. Penelitian Ini dilakukan pada tanggal 23 Juni, Lokasi penelitian ini dilaksanakan di CV.Suka Maju di Kelurahan Massepe, Kecamatan Tellu Limpoe, Kabupaten Sidenreng Rappang dengan sampel 15 responden. Metode yang digunakan yaitu metode survei melalui observasi dan wawancara. Analisa data yang digunakan pada penelitian adalah analisis deskriptif dengan menggunakan skala likert. Sebagai skala pengukuran Terganggu, Cukup Terganggu dan Tidak Terganggu dengan indikator Limbah, Kebersihan dan Bau di Kelurahan Massepe Kecamatan Tellu Limpoe Kabupaten Sidenreng Rappang. Presepsi masyarakat terhadap keberadaan peternakan Sapi Potong di Kelurahan Massepe Kecamatan Tellu Limpoe Kabupaten Sidenreng Rappang. Terhadap dampak sosial yaitu dapat memudahkan masyarakat untuk membeli daging tanpa harus keluar jauh. sedangkan dampak lingkungan dengan upaya yang dilakukan masyarakat dalam menanggulangi keberadaan limbah yaitu memanfaatkan sebagai pupuk kompos atau menimbung limbah tersebut..