bluuebunny/crossref_metadata_2025_split huggingface dataset:
pH‐Controlled DNA Switching Circuits with Multi‐State Responsiveness for Logic Computation and Control
Authors: Shi Peijun , Zhang Xiaokang , Cui Shuang , Sun Lijun , Liu Xin , Wang Bin , Zhang Qiang 
Published: January 2025

AbstractDynamic control of DNA circuit functionality is essential for constructing chemical reaction networks (CRNs) that implement complex functions. The triplex has been utilized for dynamically regulating the diverse functionalities of DNA circuits due to its distinctive pH responsiveness. However, it is challenging for triplexes to independently regulate the functionality of DNA circuits, as various triplexes were often required for DNA circuits to function in complex environments, which adds complexity to the design and control of dynamic circuits. Here, we proposed a pH‐controlled multi‐state DNA switching circuit construction strategy to realize dynamic regulation among three states through conformational transitions of the triplex. In addition, by leveraging the regulatory role of multi‐state DNA switching circuits on the toehold‐mediated strand displacement reaction, we constructed switchable DNA circuits for logic computation and control of hybridization chain reaction (HCR). We confirmed that the designed DNA switching circuits exhibited multi‐state responsiveness, allowing for different logical operations at varying pH levels and programmable control of the diverse reaction pathways in the HCR. Our strategy offers a convenient approach for the intelligent response and dynamic regulation of large‐scale CRNs and DNA nanostructure self‐assembly. It promises applications in biosensing, disease detection and drug delivery.
DNA damage response and repair gene mutations predict clinical outcomes in biliary tract cancer
Authors: Tan Sirui , Feng Mingyang , Zhou Nan , Zhang Shunyu , Yi Cheng , Gou Hongfeng 
Published: January 2025

AbstractBackgroundThis study aims to explore the genetic characteristics of biliary tract cancer (BTC), with a particular focus on the impact of DNA damage response and repair (DDR) genes on clinical outcomes.MethodsA total of 180 patients with BTC and next‐generation sequencing data were retrospectively analyzed. Clinical outcomes were compared between DDR‐positive and DDR‐negative groups.ResultsDDR mutations were found in 28.3% of patients, with ATM (7.8%), BAP1 (5.6%), and BRCA2 (3.3%) being the most common. DDR‐positive patients receiving first‐line platinum‐based chemotherapy (n = 73) had a signiﬁcantly higher objective response rate (50.0% vs. 14.9 %; p = .001), longer median progression‐free survival (mPFS) (7.7 vs. 3.8 months; p = .001) and longer median overall survival (28.6 vs. 11.9 months; p < .001). Multivariate analysis confirmed that deleterious DDR gene mutations were independently associated with prolonged mPFS (hazard ratio [HR], 0.37; 95% CI, 0.20–0.67; p < .001) and median overall survival (mOS) (HR, 0.19; 95% CI, 0.08–0.46; p < .001). In 56 patients receiving immunotherapy combined with chemotherapy, DDR‐positive patients had a signiﬁcantly higher overall response rate (45% vs. 8.3%; p = .001), longer mPFS (7.7 vs. 3.8 months; p = .009), and longer mOS (12.7 vs. 8.8 months; p = .011). Multivariate analysis showed that the presence of deleterious DDR gene mutations was associated with significantly longer mPFS (HR, 0.34; 95% CI, 0.16–0.73); p = .005] and mOS (HR, 0.23; 95% CI, 0.08–0.62; p = .004).ConclusionDeleterious DDR gene mutations are associated with improved clinical outcomes in patients with BTC treated with platinum‐based chemotherapy or immunotherapy combined with chemotherapy.
Practical management of adverse events in patients receiving tarlatamab, a delta‐like ligand 3–targeted bispecific T‐cell engager immunotherapy, for previously treated small cell lung cancer
Authors: Sands Jacob M. , Champiat Stéphane , Hummel Horst‐Dieter , Paulson Kelly G. , Borghaei Hossein , Alvarez Jean Bustamante , Carbone David P. , Carlisle Jennifer W. , Choudhury Noura J. , Clarke Jeffrey M. , Gadgeel Shirish M. , Izumi Hiroki , Navarro Alejandro , Lau Sally C. M. , Lammers Philip E. , Huang Shuang , Hamidi Ali , Mukherjee Sujoy , Owonikoko Taofeek K. 
Published: January 2025

AbstractTarlatamab is a bispecific T‐cell engager immunotherapy targeting delta‐like ligand 3 (DLL3) and the cluster of differentiation 3 (CD3) molecule. In the phase 2 DeLLphi‐301 trial of tarlatamab for patients with previously treated small cell lung cancer, tarlatamab 10 mg every 2 weeks achieved durable responses and encouraging survival outcomes. Analyses of updated safety data from the DeLLphi‐301 trial demonstrated that the most common treatment‐emergent adverse events were cytokine release syndrome (53%), pyrexia (38%), decreased appetite (36%), dysgeusia (32%), and an emia (30%). Cytokine release syndrome was mostly grade 1 or 2 in severity, occurred primarily after the first or second tarlatamab dose, and was managed with supportive care, which included the administration of antipyretics (e.g., acetaminophen), intravenous hydration, and/or glucocorticoids. Other treatment‐emergent adverse effects of interest included neutropenia (16%) and immune effector cell‐associated neurotoxicity syndrome and associated neurologic events (10%). Given that tarlatamab is the first T‐cell engager approved for the treatment of small cell lung cancer, raising awareness with regard to the monitoring and management of tarlatamab‐associated adverse events is essential. Here, the authors describe the timing, occurrence, and duration of these adverse events and review the management and risk‐mitigation strategies used by clinical investigators during the DeLLphi‐301 trial.
Design a Functional Graphene with Decoration of Dual Transition Metal Dopants for Hydrogen Evolution Electrocatalysis
Authors: Yang Cheng‐Fang , Yang Fei , Feng Zi‐Yang , Fu Rui‐Yi , Xu Chang‐Chun , Su Chao , Kong Wei , Xiao Bei‐Bei 
Published: January 2025

AbstractSince hydrogen is a promising alternative to fossil fuels due to its high energy density and environmental friendliness, water electrolysis for hydrogen production has received widespread attentions wherein the development of active and stable catalytic materials is a key research direction. This article designs a dual transition metal doped functional graphene for hydrogen evolution reaction via density functional theory calculations. Among varied combinations, 16 candidates are screened out that are expected to be stable as reflected by the criterion of formation energy Ef<0 and active due to its free energy of hydrogen adsorption ▵GH within the window of ±0.3 eV. Considering its feasibility in structural modification and electronic adjustment due to the strong dd orbital couplings, the homogeneous dual‐atom moiety delivers improved performance toward hydrogen evolution in comparison with the single‐atom counterpart. Owing to the good resistance of electrochemical dissolution, the work figures out the potential combinations of Cu2C3N3, Rh2C6, Rh2C3N3 and Rh2N6 endowed with the ▵GH values of −0.03, 0.12, −0.21, and 0.06 eV, respectively, being comparable to the benchmark Pt materials. Therefore, this study provides a new direction for the experimental synthesis of highly active carbon‐based electrocatalysts and highlights the well‐tuning ability posed by the dual‐atom interaction.
Two Decades of Research on the Relation of CSR With Earnings Management: Mapping Heterogeneity and Future AGENDA
Authors: Jhunjhunwala Shital , Fatima Sidra 
Published: January 2025

ABSTRACTThis literature review uses a blend of systematic literature review and thematic analysis to explore the relationship between corporate social responsibility (CSR) and earnings management (EM). The literature review search is guided by PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) and analyses 94 Scopus‐indexed articles ranging from 2008 to 2023. The paper reveals the most influential articles and authors, leading countries, and journals. The paper also comprehends that research on this topic needs to be clarified, with some studies suggesting a positive relationship between CSR practices and EM while others point to a negative correlation. Then, again, other research indicates mixed findings, suggesting this relationship might be more complicated and context‐dependent. In addition to highlighting the significance of considering contextual factors, the review attempts to identify the sources of heterogeneity in these findings. We also present an explanatory framework primarily ignored in previous studies to understand the sources of heterogeneity. The review also points out gaps in existing literature and suggests avenues for future research. In summary, this review offers valuable insight for scholars and professionals who want to navigate the dynamic interplay of CSR and EM in the contemporary business world.
Nanoconfinement‐Driven Energy‐Efficient CO2 Capture and Release at High Pressures on a Unique Large‐Pore Mesoporous Carbon
Authors: Szabó László , Inoue Mizuki , Sekine Yurina , Motokawa Ryuhei , Matsumoto Yusuke , Nge Thi Thi , Ismail Edhuan , Ichinose Izumi , Yamada Tatsuhiko 
Published: January 2025

AbstractAlthough microporous carbons can perform well for CO2 separations under high pressure conditions, their energy‐demanding regeneration may render them a less attractive material option. Here, we developed a large‐pore mesoporous carbon with pore sizes centered around 20–30 nm using a templated technical lignin. During the soft‐templating process, unique cylindrical supramolecular assemblies form from the copolymer template. This peculiar nanostructuring takes place due to the presence of polyethylene glycol (PEG) segments on both the Pluronic® template and the PEG‐grafted lignin derivative (glycol lignin). A large increase in CO2 uptake occurs on the resulting large‐pore mesoporous carbon at 270 K close to the saturation pressure (3.2 MPa), owing to capillary condensation. This phenomenon enables a CO2/CH4 selectivity (SCO2/CH4, mol/mol) of 3.7 at 270 K and 3.1 MPa absolute pressure, and a swift pressure swing regeneration process with desorbed CO2 per unit pressure far outperforming a benchmark activated carbon (i.e., notably rapid decrease in the amount of adsorbed CO2 with decreasing pressure). We propose large‐pore mesoporous carbons as a novel family of CO2 capture adsorbents, based on the phase‐transition behavior shift of CO2 in the nanoconfined environment. This novel material concept may open new horizons for physisorptive CO2 separations with energy‐efficient regeneration options.
A Network Partitioning Method for Real‐Time Simulation of Power System Based on State‐Space and Branch Cutting
Authors: Sheng Haoyun , Wang Guangsen , Chen Guoyong , Wang Zhiwei , Liu Qing 
Published: January 2025

ABSTRACTWith the sustainable development of the power system, the dynamic characteristics of the system are becoming increasingly complex. The electric network partitioning method is an effective approach for implementing real‐time simulation of complex power systems. This paper proposes a novel electric network partitioning method based on state space and branch cutting, aiming to enhance efficiency and precision of real‐time simulation. In the proposed method, the entire system is partitioned into multiple subsystems through branch cutting. Each cut branch is modeled based on Kirchhoff's voltage law and the characteristics of components. Each subsystem is solved using the state‐space method, and all subsystems can be simulated in parallel. Compared with traditional network partitioning methods, the proposed method effectively reduces the computational cost resulting from integrating state‐space and branch cutting methods. Additionally, the proposed method eliminates the need for time delay, which can ensure high precision. Finally, the advantages of the proposed method are verified through several real‐time simulations of an RLC circuit, a grid‐connected inverter system with an LCL filter, and a boost‐inverter system.
Efficacy of e‐learning using video content in improving trainees’ biliary cannulation skills and understanding (with video)
Authors: Kaneko Junichi , Kobayashi Yosuke , Takinami Masaki , Kimata Masaharu , Nishino Masafumi , Takahashi Yurimi , Yoshizawa Yashiro , Murohisa Go , Hosoda Yoshisuke , Yamada Takanori 
Published: January 2025

AbstractObjectivesE‐learning with video content was created to improve trainees’ biliary cannulation techniques; this study aimed to evaluate its educational effect prospectively.MethodsE‐learning program was conducted using videos demonstrating biliary cannulation for 24 papillae, targeting trainees with 2–6 years of experience in endoscopic retrograde cholangiopancreatography. Ten consecutive cases of biliary cannulation for native papillae performed by trainees were prospectively assessed before and after the e‐learning, respectively. The primary outcome was the difficult biliary cannulation rate; the secondary outcomes included a comprehension score assigned by the trainer for each biliary cannulation (maximum of 6 points), trainee failure rate, and adverse events incidence.ResultsEleven trainees participated in the e‐learning program. The overall and per‐trainee analyses showed no significant differences in the difficult biliary cannulation rate, trainee failure rate, and adverse event incidence before and after e‐learning. However, the overall analysis showed a significant increase in comprehension scores after e‐learning (median 4 vs. 5, p < 0.01) and the per‐trainee analysis revealed that the rate of comprehension score ≥5 increased significantly after e‐learning (p = 0.02). Comprehension score <5 (odds ratio: 4.31, p < 0.01) and endoscopic retrograde cholangiopancreatography experience <3 years (odds ratio: 2.15, p = 0.01) were independent risk factors for difficult biliary cannulation. Additionally, the difficult biliary cannulation incidence showed a negative correlation with the comprehension score (p < 0.01).ConclusionsE‐learning using video content did not result in a reduction in the difficult biliary cannulation rate. However, it significantly enhanced procedural understanding, indicating its potential to support future acquisition of biliary cannulation skills.
Crystallographic Phase‐Dependent Electrochemical Properties of Layered Hydroxides for Energy Applications
Authors: Jaramillo‐Hernández Camilo , Seijas‐Da Silva Alvaro , Abellán Gonzalo 
Published: January 2025

AbstractLayered Hydroxides (LHs) have garnered increasing attention for their versatility and potential in various applications, particularly in energy storage and conversion. These materials exhibit notable chemical tunability and structural flexibility; however, misassignments between common phases – such as layered double hydroxides (LDHs), alpha, and beta phases – are still occasionally encountered, despite the distinct properties of each. This review focuses on the influence of crystallographic phases on the electrochemical properties of LHs, a topic that remains relatively underexplored. We discuss several synthetic approaches that allow for precise tuning of these phases, along with the most suitable characterization techniques, including synchrotron‐based methods, and highlight key spectroscopic features that aid in accurate phase identification. Additionally, we provide an overview of recent work from our group, which underscores the importance of crystallographic phases in shaping the electrochemical behaviour of LHs in alkaline environments, particularly for applications such as the oxygen evolution reaction. A more detailed understanding of these phase‐dependent properties is essential for the rational design of more efficient electrode materials, which could further contribute to the advancement of energy conversion and storage technologies.
Halogen‐Mediated Electrochemical C−N Bond Construction of Amine
Authors: Xie Yu‐Yang , Zhang Zhang , Wang Ying‐Chun 
Published: January 2025

AbstractOrganic electrochemical synthesis stands out for its environmentally friendly and efficient characteristics. Among these approaches, halogen‐mediated indirect electrosynthesis has gained significant attention as an efficient strategy for C−N bond formation, widely applied in the synthesis of nitrogen‐containing compounds. This review highlights recent advances in direct C−N bond formation processes for various amines under halogen‐mediated electrosynthetic conditions. The features, scope, limitations, and proposed mechanisms of these transformations are discussed in detail. We aim to provide insights into expanding the applicability of halogen‐mediated electrosynthesis, contributing to the development of sustainable synthetic methodologies.
Eight‐Week Flywheel Training Enhances Jump Performance and Stretch‐Shortening Cycle Function in Collegiate Basketball Players
Authors: Shimizu Takashi , Tsuchiya Yosuke , Ueda Hisashi , Izumi Shigeki , Ochi Eisuke 
Published: January 2025

ABSTRACTThe effects of flywheel (FW) training on jump performance, muscle function, and muscle mass in athletes have not been fully clarified. The purpose of the present study was to evaluate the effects of an 8‐week FW training program on jump performance, stretch‐shortening cycle (SSC) function, muscle strength, peak power and muscle thickness in collegiate basketball players. Twenty male college basketball players (mean age: 19.8 ± 1.3 years, height: 179.1 ± 6.7 cm, body mass: 72.9 ± 6.3 kg) were randomly assigned to either the FW training (n = 11) or control group (n = 9). The FW training group performed squat exercises, 5 sets of 8 repetitions, twice a week using the FW device. Baseline and post‐training assessments of jump heights of squat jumps (SJs), countermovement jumps (CMJs), and drop jumps (DJs) were performed in both groups. Additionally, the reactive strength index (RSI), representing SSC function; isometric maximum voluntary contraction (MVC) torque during knee joint extension; peak power during squats; and quadriceps muscle thickness were evaluated. As the results, we observed that the FW training group demonstrated significant increases in post‐training SJ height (15.1%, p = 0.03), DJ height (23.2%, p = 0.01), RSI (36.8%, p = 0.04), MVC, peak power and muscle thickness compared with pre‐training levels. Furthermore, between‐group comparisons indicated significantly higher post‐training SJ height, DJ height, RSI, MVC, peak power, and muscle thickness in the FW training group (p < 0.05). Therefore, the FW training program effectively enhanced jump performance and SSC function in male basketball players and proved beneficial for muscle strength and hypertrophy.
Comparative techno‐economic analysis of using multisource renewable energy with flexible storage systems for various environments
Authors: Hoseinzadeh Siamak , Pourfayaz Fathollah 
Published: January 2025

AbstractThis article presents a comprehensive techno‐economic analysis of integrating multisource renewable energy systems—solar panels, wind turbines, and flexible energy storage solutions (batteries, electrolyzers, and hydrogen tanks)—across various climatic regions in Iran. The study addresses the pressing need for transitioning from fossil fuels to renewables due to the environmental impacts of carbon emissions and rising global energy demands. Utilizing HOMER software for simulations, we evaluated the performance and economic viability of these renewable systems in 15 cities with diverse climatic conditions. Our findings highlight significant potential in regions like Zahedan, where favorable wind conditions enhance renewable viability, contrasted by challenges in Sari, which suffers from suboptimal solar and wind resources. The analysis demonstrates that a combination of renewable sources can effectively meet a daily electrical load of 5 MWh, contingent on careful consideration of component capacities and investment costs. Tailored solutions for different regions were emphasized to optimize energy production and reduce costs, advocating for strategic investments in renewable systems as a path to enhanced sustainability and economic viability in Iran. Moreover, the study identifies gaps in current literature, underscoring the need for more detailed investigations to further explore and optimize renewable energy systems countrywide. This research contributes to the broader discourse on sustainable energy transitions, providing valuable insights for policymakers and stakeholders aiming to invest in and develop Iran's renewable energy infrastructure.
Sustained Casing Pressure Assessment Based on Gas Leakage Rate by the State of Equation for Real Gas
Authors: Wang Jieli , Dong Xuelin , Gao Deli 
Published: January 2025

ABSTRACTGas leakage is one of the most concerning issues in wells for exploring conventional or unconventional oil and gas reservoirs, carbon sequestration, and geothermal energy. Wellbore barriers, such as tubing, casing, and cement, are the primary components that prevent the undesirable flow of subsurface fluids. However, due to the complexity of the operating condition in a harsh environment, the tubing integrity is prone to failure, causing gas leakage and forming a sustained casing pressure (SCP) at the wellhead. This work proposes a prediction model considering the real gas effect when evaluating SCP. The proposed model involves gas flow, leakage, and accumulation in the wellbore. With the pressure and temperature obtained by the flow equations as boundaries, the model estimates the gas flow rate at the leakage point and SCP. Subsequently, comparing the current leakage model with the conventional method demonstrates the model's performance. Finally, the current model is applied to an ultra‐deep well to determine the leakage location by inversion. Further sensitivity studies reveal the influences of wellbore conditions on SCP, including the production rate, depth of liquid level, and annular fluid density. The study indicates that the traditional method based on ideal gas underestimates the mass flow rate by approximately 22% compared to the current model. When the adiabatic index of the conventional method is approximated as the isentropic coefficient, the mass flow rate may agree well with the current model. It is acceptable to predict the leakage flow rate by assuming that the production gas is pure methane and ignoring the influence of gas composition. The leakage position is the most influential factor for SCP. These results would help engineers predict SCP and determine the leakage location in wells.
Microgrid Management of Hybrid Energy Sources Using a Hybrid Optimization Algorithm
Authors: Saravanakumar V. , Vijayalakshmi V. J. 
Published: January 2025

ABSTRACTThe microgrid of the renewable energy sources are used as photovoltaic (PV) panels, wind turbines (WT), fuel cells (FC), micro turbines (MT), diesel generators (DG), and battery energy storage systems (ESS), offers a promising solution. The issues posed by microgrid operators (MGOs) in managing energy from multiple sources, device as a storage, and response demand programs are addressed in this research study, which proposes a finest dispatch of energy approach for connected grid and microgrid freestanding. In order to accomplish successful energy management, the suggested strategy takes into account not only the minimization of operational expenses but also the reduction of power losses and greenhouse gas emissions. For microgrid energy management (MGEM), a new multi‐objective solution integrating a demand response program is incorporated into a mixed‐integer linear programming model. The optimization issue illustrates the techno‐commercial benefits and assesses the effect of demand response on optimal energy dispatch. Furthermore, a hybrid optimization technique combining the African Vultures Optimization technique (AVOA) and Artificial Rabbits Optimization (ARO) is projected to holder the problem of optimization, and an optimized fuzzy interface is built for scheduling the ESS. Finding the best trade‐offs between costs, emissions, and power losses is made possible by the algorithm, which offers insightful information for the microgrid energy management system. The outcome of the renewable energy sources of the all categories are examined.