bluuebunny/crossref_metadata_2025_split huggingface dataset:
O Papel dos Canabinoides no Tratamento da Fibromialgia: Uma Revisão Baseada na Evidência
Authors: Duarte Ana Rita , Stuart João , De Almeida Marta , Sonié Pedro , Teixeira Sara 
Published: September 2023

INTRODUÇÃO: A fibromialgia é uma síndrome caracterizada por dor musculoesquelética generalizada, que tem um elevado impacto na qualidade de vida e um grande consumo de recursos de saúde. Apesar de não existirem recomendações que suportem a utilização de opioides na fibromialgia, estes são largamente utilizados. Assim, há a necessidade de encontrar alternativas farmacológicas eficazes e com perfil de risco-benefício favorável. Os canabinoides são atualmente alvo de grande interesse científico, em particular devido ao seu efeito analgésico.METODOLOGIA: Realizou-se uma pesquisa bibliográfica nas bases de dados PubMed, Cochrane e NICE, de estudos publicados nos últimos 5 anos, utilizando os termos MeSH: fibromyalgia, cannabinoids e cannabis. Para estratificar o nível de evidência e a força de recomendação, foi utilizada a escala SORT.RESULTADOS: Foram selecionados nove artigos, incluindo uma guideline, quatro revisões sistemáticas, duas MAs e um ensaio clínico randomizado.CONCLUSÃO: Os canabinoides têm potencial terapêutico como tratamento adjuvante na dor crónica.
EFEKTIVITAS PENGGUNAAN PHET SEBAGAI MEDIA PEMBELAJARAN FISIKA UNTUK MENINGKATKAN PENGUASAAN MATERI FLUIDA STATIS
Authors: Rumakur Bahdiana Efriyanti , Kereh Cicylia Triratna , Latupeirissa Asry N 
Published: September 2023

This study aims to determine the effectiveness of using PhET as a medium for learning physics to increase mastery of inert fluid material for students in class X State High School 4 spooky eastern part. The type of research used is descriptive quantitative with a research design that is a one-group pretest and posttest. This research was conducted with a population of students of class X IPA at SMA Negeri 4 SBT. The sample of class X IPA-1 was 21 students who were taken at random. The data in this study were collected through test and non-test instruments, test instruments in the form of pretest and posttest, and non-test test instruments in the form of student worksheets (LKPD). The results showed that in the initial test, 100% of students failed the qualification, with an average achievement score of 7.83. The maximum achievement score is 25.8, while the minimum is 1.72. The results of the analysis of cognitive aspects during the learning process using PhET as a learning medium showed that the average student achievement score was 92.23, which was an excellent qualification. These results are collected based on completing the questions in the LKPD. The ability of students to learn shows a change. The average score of the student's final test achievement reached 91.17, which was an excellent qualification. For the N-Gain test, results obtained 0.8, which is in the high category. In the effectiveness test that the results of the calculation of the t-count 48.45 and t-table 2.080 with a significant level of 5%, the t-count value is 48.45 > t-table 2,080 where 21 students (100%) are declared effective. Thus it can be concluded that the use of PhET as a practical physics learning media to improve students' mastery of static fluid material class X State High School 4 SBT
Analysis of the role of the independent auditor on reducing time lags in financial reporting and earnings management
Authors: Kiryanto Kiryanto , Kartikasari Lisa , Cahyani Anggi Gita , Triyani Agus 
Published: September 2023

ABSTRACT
This study aims to analyze differences in the timeliness of financial reporting and earnings management in terms of auditor quality in manufacturing companies on the Indonesia Stock Exchange. based on the purposive sampling technique, a sample of 37 companies was obtained so that for 3 years of observation the data processed were 111. The hypothesis was tested using the Independent Samples Test different test. The results showed that there was no difference in the level of audit delay between companies audited by big four auditors or not. Meanwhile, the level of corporate earnings management audited by the big four or not the big four shows different results. This shows that the role of independent auditors in reducing earnings management is successful.

Keywords: Auditor Quality, Audit Delay and Earnings Management
A study of genetic profiles of grape plants preserved under the name of Dagestan variety ‘Khatmi’
Authors: Ilnitskaya E. T.  , Makarkina M. V. , Kazahmedov R. E. , Kozhevnikov E. A. , Kozina T. D. 
Published: September 2023

Background. Traditionally, the description of grape varieties is a task of ampelographic studies. However, several different grape cultivars have similar phenotypic traits. Molecular genetic characterization is the most accurate tool for cultivar identification. The development of DNA fingerprinting of varieties is the first step in this direction. An extensive database of DNA profiles of grape genotypes makes it possible to determine the varietal affiliation of unknown forms, confirm or refute the varietal correspondence of planting material. ‘Khatmi’ is an autochthonous grape variety from Dagestan. The profile of ‘Khatmi’ is presented in the VIVC international database of DNA fingerprints for grape varieties. However, an application of DNA analysis methods in grape variety studies has determined that several ancient varieties were cultivated under one name, while for others a certain variability of genotypes was observed. The objectives of the work were to study samples of ‘Khatmi’ plants from different places of growth in Dagestan by standard microsatellite loci used for grape genotyping, to assess the level of genetic similarity of the samples, and to refine the DNA profile of ‘Khatmi’. Materials and methods. Molecular genetic study was carried out on 10 samples from different ‘Khatmi’ populations. The material was picked from the collection sites of Dagestan breeding experimental station of viticulture and vegetable growing and the Dagestan Experiment Station of VIR, as well as from production plantations. DNA was extracted from herbarium specimens of young grape shoot tips by the CTAB method. The samples were genotyped by polymerase chain reaction using a standard set of primers for 9 microsatellite markers VVS2, VVMD5, VVMD7, VVMD25, VVMD27, VVMD28, VVMD32, VrZAG62 and VrZAG79 recommended by the International Organization of Grapes and Wine (OIV) for grapevine DNA fingerprinting. Amplification products were separated, and their sizes were assessed using capillary electrophoresis on an ABI Prism 3130 genetic analyzer. Results. Genotyping was done for 10 samples of grapes growing in Dagestan under the name ‘Khatmi’, including samples from different collections and places of industrial cultivation, as well as clonal variations of this variety and putative clonal variations. The two base pair differences within one of the loci distinguished the DNA profiles of the analyzed samples from that of ‘Khatmi’ presented in the international grape varieties database VIVC. It was determined that the sample under the name ‘Khatmi krupnoyagodnyi’ is closely related to ‘Khatmi’ variety by its genotype, but probably represents a clonal variation of ‘Koz uzyum’, another local variety of Dagestan. Conclusion. The DNA profile of the local Dagestan grape variety ‘Khatmi’ has been refined.
Comparative Analysis of Pre and Post merger: Effect on the Financial Performance of Microfinance Institution in Nepal
Authors: Singh Silvia , Singh Anushka , Nakarmi Samyak , Shrestha Icchya , Ghimire Subigya , Sainju Gaurav 
Published: September 2023

There are no specific studies available on the impact of mergers and acquisitions on the financial performance of Microfinance Institutions in Nepal.
Other studies available on the impact of funds and investments on the financial performance of organizations However, these studies are not directly related to the impact of mergers and acquisitions on the financial performance of Microfinance Institutions in Nepal.
This study aims to analyze the effect of pre and post-merger financial performance of Microfinance Institutions (MFIs) in Nepal. The study has taken four merged Microfinance Institutions of Nepal as the sample. The study has used paired sample t-tests to analyze the data. The findings of the study showed that after the merger, the financial performance of the Microfinance Institutions in Nepal has not improved. The study found that there were no changes in the Earning per Share, Return on Equity, Return on Asset, Net profit Margin, Current Ratio, Net interest Margin and Price to Earnings Ratio. However, the study has found out that the Debt to Equity ratio has increased after the merger process. There are several studies available on the impact of mergers and acquisitions on the financial performance of banks in Nepal.
J.J.R. Macleod: His Life and Works Before and After the Toronto Insulin Years
Authors: McHardy Kenneth Charles 
Published: September 2023

Abstract.John James Rickard Macleod, while sometimes remembered as a co-discoverer of insulin, was moreover one of the world's most accomplished academic physiologists in the early 1900s. A medical graduate in Aberdeen, Scotland, he pursued a career in physiology, travelling to Leipzig and London. Precocious progress in research, teaching, and writing saw him being appointed a physiology professor in Cleveland, Ohio, at the age of 27. He gained an international reputation in carbohydrate metabolism, publishing a monograph on diabetes in 1913. A move to Toronto in 1918 soon saw him leading the team that produced the world's first clinically useful, life-saving insulin. Despite sharing a Nobel Prize, his involvement in the insulin story was mired in unjustified and persistent controversy. Returning to Aberdeen in 1928 as the head of physiology, his wide-ranging success continued until his death in 1935. This article details his life, work, and many achievements both before, and after, the Toronto insulin years.
ОЦІНКА ЯКОСТІ ЕФЕКТИВНОСТІ ЗАСТОСУВАННЯ БАГАТОКРИТЕРІАЛЬНОЇ МОДЕЛІ ІДЕНТИФІКАЦІЇ НЕШТАТНИХ СИТУАЦІЙ
Authors: СОРОКОПУД Тетяна , ПИСАРЧУК Олексій 
Published: September 2023

В роботі наведено результати апробації багатокритеріальної моделі ідентифікації нештатних ситуацій за сукупністю ознак на об’єктах критичної інфраструктури.
Основним фактором якості побудованої моделі є оцінка результативності її показників, щодо виявлення та вирішення задачі ідентифікації нештатних ситуацій на об’єктах критичної інфраструктури.
Отримані результати демонструють, що запропонована модель за показниками ефективності може бути впроваджена в діючі об’єкти критичної інфраструктури.
Expert-Free Online Transfer Learning in Multi-Agent Reinforcement Learning
Authors: Castagna Alberto , Dusparic Ivana 
Published: September 2023

Transfer learning in Reinforcement Learning (RL) has been widely studied to overcome training challenges in Deep-RL, i.e., exploration cost, data availability and convergence time, by bootstrapping external knowledge to enhance learning phase. While this overcomes the training issues on a novice agent, a good understanding of the task by the expert agent is required for such a transfer to be effective. As an alternative, in this paper we propose Expert-Free Online Transfer Learning (EF-OnTL), an algorithm that enables expert-free real-time dynamic transfer learning in multi-agent system. No dedicated expert agent exists, and transfer source agent and knowledge to be transferred are dynamically selected at each transfer step based on agents’ performance and level of uncertainty. To improve uncertainty estimation, we also propose State Action Reward Next-State Random Network Distillation (sars-RND), an extension of RND that estimates uncertainty from RL agent-environment interaction. We demonstrate EF-OnTL effectiveness against a no-transfer scenario and state-of-the-art advice-based baselines, with and without expert agents, in three benchmark tasks: Cart-Pole, a grid-based Multi-Team Predator-Prey (MT-PP) and Half Field Offense (HFO). Our results show that EF-OnTL achieves overall comparable performance to that of advice-based approaches, while not requiring expert agents, external input, nor threshold tuning. EF-OnTL outperforms no-transfer with an improvement related to the complexity of the task addressed.
Rank-Envy-Freeness in Roommate Matchings
Authors: Coutance Baptistin , Maddila Prasanna , Wilczynski Anaëlle 
Published: September 2023

In the roommate problem, pairs of agents must be formed, based on ordinal preferences of the agents over each other. In this article, we examine fair roommate matchings by relaxing envy-freeness to account for justified envy based on the rank in the agents’ preferences. A rank-envy-free matching prevents that an agent prefers the partner of another agent whereas she has ranked it better. Although this requirement is pretty weak in house allocation [9], we show that it is more demanding in the roommate setting. We study parameterizations of rank-envy-freeness, as well as further natural relaxations of this concept. We also investigate the connections between the family of rank-based fairness criteria and known optimality or stability concepts.
Pemberian Hadiah Dalam Pemilihan Kepala Desa Menurut Siyasah Syariyyah
Authors: ‎    ‎ Taufid Hidayat Nazar 
Published: September 2023

Pemilihan kepala desa yang diadakan oleh pemerintah tidak dipungkiri adanya pemberian berupa harta ataupun berupa janji yang diberikan pada masyarakat tertentu melalui para tim sukses, begitulah cara yang telah dilakukan oleh para calon untuk bisa menarik simpati para pemilih. Namun, dalam Islam sudah mengajarkan untuk memperoleh kekuasaan dengan tidak curang dalam membeli suara apalagi memanipulasinya maka dari itu dalam menjalankan amanah dan melaksanakan kekuasaan diperlukan juga memelihara harta. Di bolehka n mengambi l pemberia n selama pemberia n yang diberika n karena Alla h SWT. Pemberia n hadia h murni tanpa imbala n. Buka n untu k maksud yang lai n. Namu n, jika dala m pemberia n hadia h tersebut memiliki tujua n tertentu maka ha l tersebut tida k diperbolehka n. Menurut Perspektif Huku m Isla m tindaka n pemberia n hadia h sama denga n sua p menyua p atau risywa h. Sedangka n mengenai perbuata n sua p menyua p ini, larangannya tela h diturunka n seja k awa l kenabia n Muhammad Saw. Pengatura n mengenai laranga n untu k melakuka n perbuata n sua p menyua p itu sendiri diturunka n Alla h Swt.
Fixed Collocations with Epitheta Ornantia in the Livonian Rhymed Chronicle in Terms of Historical Pragmalinguistics
Authors: Tikhonova E. S. 
Published: September 2023

Introduction. The paper considers Middle High German poetic nominations of a warrior such as helt ‘hero’, ritter ‘knight’ and degen ‘warrior’ combined with epitheta ornantia. The aim of this paper is to find out the most characteristic contexts for these lexemes.Methodology and sources. The research is based on methodology of historical pragmalinguistics and cognitive linguistics, in particular on the frames’ theory by Ch. Fillmore. As material for the research serves the Livonian Rhymed Chronicle (late XIIIth cent.), written in the East Middle German dialect. The text’s linguistic features are scarcely studied by historical linguists in Russia. The Chronicle was written under the influence of courtly epics, which fact was discussed by U. Arnold, M. Fischer, H. Kugler, A. Murray and others.Results and discussion. In the Chronicle’s text there were selected 10 frames that include the analyzed nouns with epitheta ornantia. The noun helt can also be found in parts including and introducing direct speech. Each of the three nouns was analyzed as to in which frames it is attested and which epitheta are more common in each frame.Conclusion. A conclusion was drawn that the noun helt ‘hero’ appears in almost all the frames, ritter ‘knight’ appears mostly in frames that refer to static situations and degen ‘warrior’ – in frames that refer to dynamic situations. Moreover, the lexeme helt ‘hero’ has a wider distribution range in the Chronicle than the other two nouns.
Representation of a Perceptual Event in an Interview with an Artist
Authors: Petukhova T. I. , Chupakhina A. O. 
Published: September 2023

Introduction. The purpose of the research is to consider the linguistic actualization of the main characteristics of the artist's visual perception in the interview discourse. The relevance of the research is due to its inclusion in the context of modern anthropo-oriented study of cognition of the world by a creative person. The novelty of the research lies in the fact that for the first time the process of perception of the world by an English-speaking artist is studied as an event within the framework of a complex linguistic and cognitive approach, which allows to analyze its specificity to the fullest extent.Methodology and sources. The methodological basis of the research was made up of the works of the linguists-cognitologists L.V. Laenko, I.Yu. Kolesov, psychologist V. A. Barabanshchikov who revealed distinctive characteristics of perceptual image and substantiated the expediency of perception as an event. The research material was interviews with English-speaking artists from the Internet versions of the newspapers devoted to the life and work of modern artists. The methods of lexico-semantic, frame, contextual and pragmalinguistic analysis were used.Results and discussion. The article reveals the peculiarities of visual perception of the world by contemporary English-speaking artists, which are reflected in the discourse of the interview. The author reveals the multidimensionality of a subject of perception, different ways of its representation on the verbal level: as an observer-actor and as a “offscreen” observer. The paper shows the specificity of visual perception of the world by the artist as a perceptual event that possesses spatial and temporal coordinates and such significant characteristics as dynamism, motivation, focus and emotionality. The denotative situation of perception is actualized in English by personal pronouns, active-action predicates, perceptual predicates, existential constructions, phase verbs, and state change predicates. The important feature of the artist's creative perception of the world is the forming of the necessity of representation in his consciousness perceptive image by means of painterly signs. As a result of such representation the given perceptive image receives the further development and becomes the basis for creating an artistic image to be embodied in an art work.Conclusion. In the interview with the artist there is a complex process of cognition of the world by the creative person, based on the perceptual event. Visual perception is represented by the artist as a directed activity, which is to learn and which requires certain efforts and motivation. As a result of the perceptual event that the artist experiences, an artistic image is formed that is actualized in the work of art.
The Space of the Children's World: the Problem of Transformation
Authors: Yurieva A. V. 
Published: September 2023

Introduction. The space of the children's world evolves together with a person's ideas about oneself, the world around them, the development of scientific and technological progress. The purpose of this study is to describe the transformation of the space of the child's world, the change in the socio-cultural position of the child through the acquisition of his / her personal physical space along with the discovery of his /her inner mental world. The relevance is determined by the complexity of the spatial coordinates of the children's world associated with the digitalization of childhood. Scientific novelty consists in an attempt to systematize scientific knowledge in the description of the space of the children's world and to evaluate them from the point of view of the modern socio-cultural state.Methodology and sources. The methodological basis of the work is a cultural philosophical analysis. The works of G. Bachelard, A. Lefebvre, M. Foucault and other authors were used as a philosophical understanding of the problem of space. Cultural and ethnographic analysis of the phenomenon of childhood, carried out in the works of F. Aries, J. Duby, M. Mead, K. Levi-Strauss, contributed to the understanding of the space of the children's world and the problem of its transformation.Results and discussion. The space of the children's world is associated with a combination of various socio-cultural factors that change throughout historical time. The space of the children's world opens up in the eyes of an adult with the manifestation of interest in children's experiences, the inner psychological structure of the child. Great importance in the transformation of the childhood space occurs at the moment when the child finds his / her own “place” in the house. The traditional expansion of the space of the children's world (house-street-city-country-world) in modern times acquires another dimension – virtuality.Conclusion. The evolution of the socio-cultural position of the child in society depended on the specifics of ideas about the rules of behavior, social habits, ritual practices. For a long time, the space of the children's world was perceived as fundamentally different from the space of an adult, carried beyond its limits. The digitalization of childhood has provided the world with new dangers associated with the risks of finding a child in virtual spaces beyond the control of an adult.
Evaluation of the effectiveness of immunomodulator BI-V in the complex therapy of children and adolescents with multiple drug-resistant pulmonary tuberculosis
Authors: Sakhelashvili-Bil O.I. , Platonova I.L. 
Published: September 2023

BACKGROUND. The feasibility of combining antimycobacterial therapy (AMBT) with bedaquiline (Bdq) and delamanid (Dlm) with non-specific immunomodulator BI-V in children and adolescents with multidrug-resistant and rifampicin-resistant pulmonary tuberculosis (MDR/Rif-TBP) needs to be studied.
OBJECTIVE. To find out the effectiveness of the use of complex AMBT with Bdq and Dlm with non-specific immunomodulator BI-V in children and adolescents with MDR/Rif-TBP.
MATERIALS AND METHODS. Children and adolescents with MDR/Rif-TBP at the initial stage of AMBT were given BI-V (BIVEL, Slovenia) as a non-specific immunomodulator. The patients were divided into two groups: 1st – 20 patients who received Bdq + Dlm + levofloxacin (Lfx) + linezolid (Lzd) + clofazimine (Cfz); 2nd ‒ 28 patients whose complex treatment included BI-V (Вdq + Dlm + Lfx + Lzd + Cfz + BI-V). BI-V was prescribed from the age of 3 years at 5 ml suspension once a day during 24 days
RESULTS. The use of BI-V against the background of individualized regimens of AMBT in children and adolescents with MDR/Rif-TBP increased the effectiveness of treatment, contributed to the disappearance of symptoms of intoxication, the resolution of infiltration foci and the healing of decay cavities in system of immune protection, which contributed to the shortening of the inpatient stage of treatment, while maintaining a high therapeutic effectiveness (“cured” ‒ 92.8 %) and the formation of small residual changes in the lungs in the majority (89.3 %).
CONCLUSIONS. When using combined complex AMBT with Bdq, Dlm and BI-V, high therapeutic efficiency was observed in most patients (92.8 %).