bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Produksi Video dengan Telepon Pintar untuk Peningkatan Kreativitas Promosi Desa Wisata Dewi Carakan, Wijirejo
Authors: Sadewa Ghalif Putra 
Published: December 2023

Telepon pintar sebagai teknologi paling mutakhir, di satu sisi berperan aktif dalam menyebarluaskan konten digital, baik itu teks, gambar, maupun video. Di sisi lainnya, teknologi yang disematkan di dalamnya memungkinkan pengguna untuk mengeksplorasi dan menumbuhkan ide-ide dalam penciptaan konten digital. Kedua hal ini lantas digunakan oleh Pokdarwis Desa Wisata Dewi Carakan, Wijirejo guna menggenjot potensi wisata desa melalui ragam promosi digital. Meskipun demikian, belum optimalnya pemanfaatan telepon pintar menjadi satu kendala dalam proses produksi yang kini dihadapi oleh Pokdarwis Dewi Carakan. Tujuan dari pengabdian ini adalah untuk meningkatkan kreativitas dan keterampilan dalam membuat konten promosi desa wisata menggunakan telepon pintar. Metode pengabdian kepada masyarakat yang diterapkan berupa ceramah, diskusi, praktik, dan evaluasi. Hasil dari pengabdian ini mampu menumbuhkan kreativitas dan keterampilan pengelola Desa Wisata Dewi Carakan dalam memproduksi konten video promosi desa dengan telepon pintar. Wujud nyata luaran pengabdian ini adalah lahirnya enam konten audiovisual yang seluruh prosesnya dibidani pokdarwis dan telah didistribusikan ke kanal Youtube, TikTok, serta Instagram baik milik pribadi maupun Dewi Carakan. Smartphones, the most cutting-edge technology, actively play a role in disseminating digital content either in the form of texts, images, or videos. As smartphones are getting more sophisticated, the technology embedded within them encourages users to explore and nurture ideas for creating limitless digital contents. This kind of phenomena leads the Pokdarwis (Community-based Tourism Group) of Dewi Carakan Tourism Village to promote the village potentials through various digital promotions. Despite the epic goal, the suboptimal utilization of smartphones in the production process conducted by Pokdarwis of Dewi Carakan poses a challenge. Therefore, the aim of the training activity is to enhance creativity and skills of the villagers in creating promotional content of the tourism village using smartphones. The method applied by the authors was lectures, discussions, practical exercises, and evaluations. The result shows that due to this program the managers of Dewi Carakan tourism village are more creative and skilful in producing promotional video content village using smartphones. The output of the program is six audio-visual contents, in which the entire process was carried out by Pokdarwis. Those six contents have been uploaded to both their own social media and Dewi Carakan’s including YouTube, TikTok and Instagram channels.
Role of echocardiography in heart failure with preserved ejection fraction
Authors: Soldatova A. M. , Shirokov N. Е. , Yaroslavskay E. I. 
Published: December 2023

This study aimed to investigate and analyze data regarding the role of echocardiographic examination in assessing the diastolic function of the left ventricle and diagnosing heart failure with preserved ejection fraction (HFpEF).Materials and methods. A search of scientific publications and clinical recommendations was conducted in the PubMed and Google Scholar information-analytical systems for the years 2016–2022, using keywords such as diastolic dysfunction, diastolic stress test, heart failure with preserved ejection fraction, and echocardiography. Additionally, literature lists were analyzed to identify articles meeting the search criteria.Results. A total of 140 articles were analyzed, with 27 of them utilized in composing the review. Eleven additional articles from 2003–2015 were included from literature lists. The search results were organized into article blocks, within which articles were analyzed to study the role of echocardiographic examination in assessing the diastolic function of the left ventricle and diagnosing HFpEF.Conclusion: Echocardiographic examination provides crucial information about the structure and function of the heart and is recommended for all patients with suspected HFpEF. Based on routine assessment of tissue Doppler imaging parameters, ultrasound diagnostic physicians can decide on the need to initiate the diagnostic algorithm for HFpEF using the diastolic stress test method. Results of the diastolic stress test, considering its limitations, should be interpreted in accordance with the clinical scenario or the probability of the presence of HFpEF. A reduction in diastolic reserve (E/e > 15) is a cornerstone for confirming HFpEF. The key task of upcoming clinical trials is to better differentiate various clinical phenotypes of HFpEF, thereby improving the treatment of each specific patient with HFpEF.
Clinical application of new classification of the calyx-pelvic system dilation UTD in children in a perinatal center
Authors: Sugak A. B. , Babatova S. I. , Filippova E. A. , Batdalova Z. N. , Podurovskaya Yu. L. , Pavlova V. S. , Pekareva N. A. , Pykov M. I. , Zubkov V. V. 
Published: December 2023

The aim of the study was to evaluate the clinical significance of the new urinary tract dilation classification (UTD-2014) in predicting outcomes of the calyx-pelvic system dilation detected by ultrasound (US) in children in the perinatal center.Materials and methods. A retrospective analysis of the urinary system ultrasound protocols and the outcomes of 152 children with dilated calyx-pelvic system due to various causes examined at the National Medical Research Center for Obstetrics, Gynecology and Perinatology for the period from 2017 to 2022 was carried out.Results. The median age of patients at the time of the first ultrasound was 2 days, the median duration of follow -up was 10 months. The decrease in the UTD category during the observation period occurred in –/35/29/10% of patients in groups with the primary established UTD category 0/I/II/III, respectively. The UTD category remained the same in 42%, an increase in the category occurred in 32/26/4/-% of patients with UTD 0/I/II/III, respectively. The age at the time of the first ultrasound of patients who had an increase in the UTD category (median – 2 (1; 3.5) days) was significantly less than in other children (with the exception of operated patients). Surgical intervention was performed by 0/2/31/60% of patients with UTD category 0/I/II/III (only 18%), respectively.Conclusions. UTD classification correlates well with outcomes of the calyx-pelvic system dilation due to various causes in children – the larger the category according to primary ultrasound, the less often its decrease or lack of dynamics is noted during follow-up, surgical treatment is more often necessary. When using the UTD classification in the perinatal center, there is a high risk of underestimating the degree of dilatation due to the early conduct of the first ultrasound in the first two days of life.
Causes and nature of traumatic brain injury in a metropolis and the organization of assistance to victims in a multidisciplinary hospital
Authors: Dudanov I. P. , Podgornyak M. Yu. , Pavlov O. A. , Mitichkin M. S. , Verbitskii O. P. , Lazorkin V. A. 
Published: December 2023

THE OBJECTIVE of the study was to study the causes and nature of traumatic brain injury in a metropolis and to form the principles of providing assistance to victims in a multidisciplinary hospital.METHODS AND MATERIALS. The analysis of a sequential sample of 2017 case histories of patients admitted to St. Petersburg State Medical Institution “Mariinsky City Hospital” for urgent indications with injuries of the skin of the head, skull bones, brain of varying severity was carried out. They accounted for 69 % of the total number of injured patients (2,932 people) admitted with injuries to various parts of the body, including the head, from August 2021 to February 2022. We analyzed 114 case histories of patients treated in the intensive care unit (ICU). The mortality rate in this group was 36 % (41 out of 114 people). The work is illustrated by clinical observations with typical urban injuries, which were caused by icicles falling on the head, blocks of snow from the roofs of houses, incidents with personal mobility equipment on the sidewalks of the city, falls on ice and other causes.RESULTS. Based on clinical examples, the causes and features of urban traumatic brain injury in a metropolis, criteria for sorting and routing patients admitted with signs of traumatic brain injury were considered.
Prevention of complications from the laparotomy wound in abdominal gunshot injury
Authors: Maistrenko N. A. , Sazonov A. A. , Romaschenko P. N. , Makarov I. A. 
Published: December 2023

The OBJECTIVE was to evaluate the effectiveness of the original technique for assessing the reparative potential of the anterior abdominal wall in the prevention of complications from the laparotomic wound in abdominal gunshot injury.METHODS AND MATERIALS. The comparative assessment of the results of surgical treatment of 145 victims with abdominal gunshot injury, which were divided into 2 groups, was made. The retrospective group included 92 patients who underwent a standard approach to the prevention of infectious complications in the surgical area: perioperative administration of antibiotics, daily dressings, as well as laboratory monitoring of acute phase parameters and instrumental assessment of tissue condition (ultrasound). The prospective group was formed from 53 patients in whom, as part of the prevention of the infectious process, the original method for assessing the reparative potential of the tissues of the anterior abdominal wall was used (priority certificate for the invention ¹ 2023109198 dated 04/12/2023). The studied groups were comparable in terms of the main clinical criteria: the age of the victims, the severity of injuries, and the structure of surgical interventions.RESULTS. Suppuration of the laparotomic wound was noted in 22 patients in the retrospective group and in 4 in the prospective group, which accounted for 23.9 % and 7.5 % of their number (p=0.014). Eventration was observed in 11 patients in the retrospective group and in one patient in the prospective group (11.9 % and 1.9 %, p=0.05).CONCLUSION. The use of the original technique for assessing the reparative potential of the tissues of the anterior abdominal wall makes it possible to reduce the incidence of complications from the laparotomic wound in abdominal gunshot injury.
Hands-on neuroendovascular practice for nonselective undergraduate medical students increases interest and aspirations in pursuing neurosurgery as a specialization
Authors: Michiwaki Yuhei , Yamane Fumitaka , Itokawa Hiroshi , Tanaka Tatsuya , Shimoji Kazuaki , Matsuno Akira 
Published: December 2023

Background:The number of medical students aspiring to become neurosurgeons has decreased worldwide, mainly due to poor work-life balance among neurosurgeons; therefore, recruiting students for neurosurgery is essential to ensure the availability and appropriate quality of neurosurgical treatment. This study aimed to evaluate the efficacy of hands-on neuroendovascular practice for nonselective undergraduate medical students to determine whether this increases their interest in neurosurgery and contributes to their aspirations of becoming neurosurgeons.Methods:Hands-on neuroendovascular practice for mechanical thrombectomy was performed by undergraduate 5th-year medical students during their 2-week clinical rotation in the Department of neurosurgery at our university hospital between April 2021 and March 2023. After the neurosurgery practice, a questionnaire about their understanding of neurosurgery and aspirations for this specialization before and after the practice was anonymously completed by all students.Results:Overall, 153 students completed the questionnaire. Of these, 140 (91.5 %) showed increased interest in neurosurgery after participating in the hands-on practice. Through this practice, the number of students who considered neurosurgery as their first choice or one of their specialty choices increased from 8 (5.2%) to 12 (7.8%) (P= 0.3534) and from 19 (12.4%) to 52 (34.0%) (P< 0.0001), respectively. Furthermore, the number of students with no aspiration to become neurosurgeons decreased from 95 (62.1%) to 43 (28.1%) (P< 0.0001).Conclusion:Hands-on neuroendovascular practice for nonselective undergraduate medical students effectively increased their interest in neurosurgery specialization and their desire to become neurosurgeons. Therefore, this practice can help recruit medical students for neurosurgery specialization.
The Basas Spanish Squat: Superimposition of Electrical Stimulation to Optimize Patellar Tendon Strain: A Case Series
Authors: Basas Carlos , Ito Naoaki , Grävare Silbernagel Karin , Reyes-Gil Fernando , Basas Ángel 
Published: December 2023

Background The Basas Spanish Squat with electrical stimulation (E-stim) has shown promising results as a potential key exercise in treatment of athletes with patellar tendinopathy. Gold standard exercise therapy for tendon injuries consists of tendon loading exercises, or exercises that appropriately applies high levels of mechanical strain to the tendon. The theoretical pathway in which the Basas Spanish Squat with E-stim improves tendinopathy has been speculated to be the additional strain applied through the patellar tendon during superimposition of E-stim. This theory, however, has yet to be confirmed. Purpose The purpose of this case series was to compare patellar tendon strain, during the Basas Spanish Squat with, and without E-stim, and open kinetic chain knee extension. Methods Four healthy participants performed the three exercises while a physical therapist collected simultaneous unilateral ultrasound images from the patellar tendon. Strain was calculated as the change in patellar tendon length during contraction divided by the resting length. Results Amongst all participants, patellar tendon strain was smallest during the Basas Spanish Squat without E-stim, followed by the open kinetic chain knee extension at 60% maximum voluntary isometric contraction. The Basas Spanish Squat with E-stim yielded approximately double or more strain compared to the without E-stim condition and demonstrated higher level of strain compared to open kinetic chain knee extension in all participants. Conclusion The findings reflect a clear trend of increased strain through the patellar tendon when E-stim was superimposed. The results support the theory that the Basas Spanish Squat with E-stim increases patellar tendon strain and could explain the reported clinical benefits in individuals with patellar tendinopathy. Level of Evidence 4, Case series
Relative vaccine effectiveness of mRNA COVID-19 boosters in people aged at least 75 years during the spring-summer (monovalent vaccine) and autumn-winter (bivalent vaccine) booster campaigns: a prospective test negative case–control study, United Kingdom, 2022
Authors: Chatzilena Anastasia , Hyams Catherine , Challen Rob , Marlow Robin , King Jade , Adegbite David , Kinney Jane , Clout Madeleine , Maskell Nick , Oliver Jennifer , Finn Adam , Danon Leon ,   on behalf of The Avon CAP Research Group
Published: December 2023

Background
Understanding the relative vaccine effectiveness (rVE) of new COVID-19 vaccine formulations against SARS-CoV-2 infection is a public health priority. A precise analysis of the rVE of monovalent and bivalent boosters given during the 2022 spring-summer and autumn-winter campaigns, respectively, in a defined population remains of interest.

Aim
We assessed rVE against hospitalisation for the spring-summer (fourth vs third monovalent mRNA vaccine doses) and autumn-winter (fifth BA.1/ancestral bivalent vs fourth monovalent mRNA vaccine dose) boosters.

Methods
We performed a prospective single-centre test-negative design case–control study in ≥ 75-year-old people hospitalised with COVID-19 or other acute respiratory disease. We conducted regression analyses controlling for age, sex, socioeconomic status, patient comorbidities, community SARS-CoV-2 prevalence, vaccine brand and time between baseline dose and hospitalisation.

Results
We included 682 controls and 182 cases in the spring-summer booster analysis and 572 controls and 152 cases in the autumn-winter booster analysis. A monovalent mRNA COVID-19 vaccine as fourth dose showed 46.6% rVE (95% confidence interval (CI): 13.9–67.1) vs those not fully boosted. A bivalent mRNA COVID-19 vaccine as fifth dose had 46.7% rVE (95% CI: 18.0–65.1), compared with a fourth monovalent mRNA COVID-19 vaccine dose.

Conclusions
Both fourth monovalent and fifth BA.1/ancestral mRNA bivalent COVID-19 vaccine doses demonstrated benefit as a booster in older adults. Bivalent mRNA boosters offered similar protection against hospitalisation with Omicron infection to monovalent mRNA boosters given earlier in the year. These findings support immunisation programmes in several European countries that advised the use of BA.1/ancestral bivalent booster doses.
RELATIONSHIP BETWEEN GRK4 POLYMORPHISMS AND ESSENTIAL HYPERTENSION. A STUDY IN A GROUP OF TURKISH SUBJECTS
Authors: YILDIZ Hale , KAN Beki , ORUN Oya , NACAR Cevdet , DOĞAN Yüksel , GÜNEYSEL Özlem , CABADAK Hulya 
Published: December 2023

Background/Purpose:
G protein-coupled receptor kinase (GRK4) is associated with essential hypertension (EHT). GRK4 regulates sodium balance in the proximal tubules of the kidney. In this study, the possible roles of A142V and A486V polymorphisms in the development of hypertension were investigated in a Turkish population.
Methods: Genomic DNA was obtained from white blood cells using the standard DNA isolation kit (Roche). Genotypes of variants of GRK4 were determined by Polymerase chain reaction (PCR) - Restriction fragment length polymorphism (RFLP) analysis.
Results: In this study, GRKA142V and A486V polymorphisms were found to be associated with EHT in the Turkish population (P
Analisis Penerapan Teknologi Augmented Reality sebagai Strategi Pemasaran IKEA
Authors: Sasmita Ida Ayu Pradnya , Dewi Putu Purnama 
Published: December 2023

Tujuan penelitian ini adalah untuk mengetahui bagaimana penerapan teknologi augmented reality sebagai media pendukung strategi pemasaran perusahaan IKEA. Pesatnya perkembangan ilmu pengetahuan dan teknologi telah membawa perubahan di berbagai bidang. Ilmu pengetahuan dan teknologi terus mengalami perkembangan seiring dengan pesatnya kebutuhan masyarakat. Salah satu dampak yang ditimbulkan dengan berkembangnya teknologi adalah terjadinya perubahan perilaku di masyarakat, seperti bergesernya budaya belanja masyarakat dari konsep tradisional yang perlahan mulai ditinggalkan dan beralih ke konsep belanja online. Hal ini menyebabkan IKEA mulai mendigitalkan dan membuka toko online melalui website dan aplikasi. Perkembangan teknologi juga memengaruhi dan membantu meningkatkan perkembangan bidang pemasaran. Inovasi baru terus bermunculan, salah satunya adalah penggunaan augmented reality di aplikasi IKEA. Augmented reality merupakan teknologi yang menggunakan sebuah teknik yang menggabungkan benda maya dua maupun tiga dimensi ke dalam sebuah lingkup nyata tiga dimensi lalu menampilkan gambar benda maya tersebut dalam waktu nyata dengan realitas virtual melalui bantuan ponsel pintar. Konsumen dapat melihat produk yang diinginkan secara real time melalui aplikasi di ponsel pengguna. Salah satu inovasi dalam penggunaan augmented reality sebagai strategi pemasaran juga telah membuahkan hasil. IKEA melakasanakan proses digitalisasi layanannya untuk dapat menarik konsumen baru. Adapun hasil yang diperoleh yaitu terdapat dampak positif yang besar setelah IKEA meluncurkan toko online dan mengembangkan aplikasi yang didukung oleh penerapan augmented reality.
Cholestatic jaundice in a sample of Iraqi Infants (A hospital based study)
Authors: Al-Azzawi Sawsan I. , Al-Badri Bayan A. , Mohammad Lana A. 
Published: December 2023

Background: Cholestatic Jaundice is a dilemma facing not only the primary care provider but also the specialist pediatricians in our country.Subjects & methods: Analysis of 50 cases of cholestatic jaundice aged 3 weeks- 18 months were carried out over 18 months in the Gastroenterology & Hepatology unit in the Children Welfare Teaching Hospital, Medical City, and Baghdad. Clinical, biochemical, radiological and histopathological results were recorded.Results: Fifty patients with Cholestatic Jaundice, 28 males &22 females, were evaluated. The main causes of Cholestatic Jaundice were Biliary Atresia in 22 cases (44%)(the mean age of presentation was 4.1 months ), and Neonatal Hepatitis Syndrome of different etiology in 17 cases (34%) (The mean age of presentation was 5.9 months).Galactosemia was the most common cause of metabolic liver disease and CMV was the commonest of the intrauterine viral infections. Two cases of choledocal cyst (4%) and no definite cause was found in 9 cases (18%)Conclusion: Biliary atresia was the most common cause of cholestasis in this study of extra-hepatic type. Different stages of cirrhosis were found in almost all cases of biliary Atresia because of delayed presentation. Clay color stool, hepatomegaly, high alkaline phosphatase & high cholesterol level favor atresia cases. Ultrasonography & liver biopsy prove to be very valuable tools in the differentiation between Biliary Atresia & Neonatal Hepatitis Syndrome.
Skipping of FCER1G Exon 2 Is Common in Human Brain But Not Associated with the Alzheimer’s Disease Genetic Risk Factor rs2070902
Authors: Feldner Alyssa C. , Turner Andrew K. , Simpson James F. , Estus Steven 
Published: December 2023

Background: Understanding the mechanisms whereby genetic variants influence the risk of Alzheimer’s disease (AD) may provide insights into treatments that could reduce AD risk. Objective: Here, we sought to test the hypothesis that a single nucleotide polymorphism (SNP) associated with AD risk, rs2070902, influences splicing of FCER1G exon 2. Methods: AD and non-AD brain samples were analyzed for FCER1G expression by genotyping, immunohistochemistry, immunofluorescence, and qPCR. Results: The protein encoded by FCER1G, FcR γ, is robustly expressed in microglia in both AD and non-AD brain. The FCER1G isoform lacking exon 2 ( D2-FCER1G) was readily detectable. Moreover, the proportion of FCER1G expressed as this isoform was increased in brains with high AD neuropathology. However, the proportion of FCER1G expressed as the D2-FCER1G isoform was not associated with rs2070902 genotype. Conclusions: In summary, the proportion of FCER1G expressed as the D2-FCER1G isoform is increased with AD neuropathology but is not associated with rs2070902.
Oxidative DNA damage estimated by urinary 8-Hydroxy-2’ –Deoxyguanosine (8-OHdG) and 8-Oxoguanine DNA Glycosylase (OGG1) in cigarette and non-cigarette smokers in South West Nigeria
Authors: Ajileye A.B. , Akinbo F.O. 
Published: December 2023

BACKGROUND: The thousands of chemicals and compounds found in cigarette smoke, including many free radicals and oxidants, can cause oxidative damage to DNA either directly or by producing reactive oxygen species in cultured cells. This study was carried out to analyze the urinary 8-Oxoguanine DNA Glycosylase (OGG1) and 8-Hydroxy-2’ –Deoxyguanosine (8-OHdG) among cigarette and non-cigarette smokers in South-West, Nigeria. METHODS: Urine samples were collected from 250 cigarette smokers and 200 non-cigarette smokers who live in south-west, Nigeria. Questionnaire was administered first to both cigarette and non-cigarette smokers prior to specimen collection. About 10mls of urine samples were collected from each of the subjects and was used to carry out Oxoguanine Glycosylase and 8-Hydroxyl-2-deoxyguanosine using spectrophotometer at 450 nm wavelength. RESULTS: There was a significant ( P < 0.05) increase in Urinary 8-OHdG (345.84±90.98 vs 223±68.48) and OGG1 (220.71±59.55 vs 97.20±56.14) of the cigarette smokers when compared with that of non-cigarette smokers. CONCLUSION: On the basis of this study, it has been observed and established that indulging in cigarette smoking can result in oxidative stress and DNA damage.