bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS PENGGUNAAN IMPLANT BERLAPIS ANTIBIOTIK PADA TERAPI OSTEOMIELITIS
Authors: Anggraeni Wahyu Puspita , Imanto Teguh 
Published: December 2023

Osteomielitis merupakan komplikasi yang umum terjadi dan menjadi tantangan bagi ahli bedah. Pengobatan osteomielitis biasanya melalui pemberian secara sistemik, namun antibiotik ketika diberikan secara sistemik kadar antibiotik yang sampai pada jaringan rendah karena pemberian secara sistemik. Implant dengan lapisan antibakteri telah dikembangkan sebagai alternatif pengganti pengobatan antibiotik secara sestemik. Dari beberapa artikel ilmiah membuktikan bahwa tingkat kesembuhan keseluruhan pasien osteomielitis adalah 65,5% hingga 95% dengan terapi lokal menggunakan implant berlapis antibiotik. Pada penelitian ini dilakukan uji meta analisis dengan tujuan untuk mengetahui efektivitas implant berlapis antibiotik yang digunakan secara monoterapi atau terapi kombinasi pada pasien osteomielitis. Metode yang digunakan pada literature review ini adalah metode boolean. Sumber informasi didapatkan dari database Science Direct dan PubMed. Data yang digunakan untuk dilakukan meta analisis yaitu sebanyak 9 data yang memenuhi kriteria dilakukannya meta analisis. Pada meta analisis dilakukan analisa pada forrest plot untuk mengetahui efektifitas penggunaan implant berlapis antibiotik gentamisin sebagai monoterapi ataupun biterapi serta dilakukan analisa pada hasil funnel plot untuk mengetahui apakah terdapat bias publikasi pada hasil meta-analisis. Hasil forrest plot menunjukkan nilai random effect model (RE model) (0,86) dimana pada penelitian terdahulu mensyaratakan bahwa nilai size effect (0,88) yang paling mendekati nilai RE model dengan estimasi yang paling akurat. Pada funnel plot menunjukkan hasil yang simetris dimana nilai p-value pada egger’s test (0,667) dan nilai fail-safe N (10373) maka hasil meta analisis ini tidak memiliki makna bias. Sehingga dari hasil meta analisis tersebut telah dibuktikan bahwa antibiotik gentamisin efektif digunakan bersamaan dengan antibiotik vankomisin pada implant berlapis antibiotik pada pasien osteomielitis.
HUBUNGAN ANTARA KEPATUHAN PENGGUNAAN OBAT DENGAN KEBERHASILAN TERAPI ANTIHIPERTENSI PADA PASIEN GERIATRI DI RUMAH SAKIT DR. MOEWARDI
Authors: Jumhani Sifwa Aulia , Mutmainah Nurul 
Published: December 2023

Kepatuhan adalah perilaku seseorang sejauh mana dapat mengikuti pengobatan, diet, atau gaya hidup sehat berdasarkan anjuran yang telah disepakati dengan pelayanan kesehatan. Kepatuhan dalam pengobatan hipertensi sangat dibutuhkan guna menunjang keberhasilan terapi. Tujuan studi ini guna mencari tahu korelasi kepatuhan pemakaian obat dengan keberhasilan terapi antihipertensi pada pasien geriatri di RSUD dr. Moewardi. Populasi di studi ini ialah pasien pada poli geriatri di RSUD dr. Moewardi yang mengidap hipertensi. Sampel pada penelitian ini yaitu pasien geriatri dengan kriteria usia lebih dari 60 tahun, terdiagnosa hipertensi, dan telah mengonsumni obat antihipertensi selama 1 bulan sebanyak 55 pasien. Studi ini ialah penelitian deskriptif dengan metode non eksperimental. Metode yang dipakai ialah cross sectional. Teknik pengambilan sampel dilakukan dengan metode accidental sampling. Instrumen yang dipakai di studi ini ialah kuesioner MMAS-8 yang telah teruji validitas dan reliabilitasnya. Data dianalisis menggunakan uji chi square dan Fisher’s exact test memakai SPSS versi 25. Hasil penelitian ini, tingkat kepatuhan pasien dalam mengonsumsi obat sebesar 70,9% responden patuh. Tingkat keberhasilan terapi antihipertensi didapat 69,1% responden berhasil terapi. Hasil uji Fisher’s exact menunjukkan bahwa dari 2 variabel memperoleh signifikan sebesar 0,022 dan ­Odds Ratio sebesar 4,982. Kesimpulannya ada korelasi kepatuhan penggunaan obat dengan keberhasilan terapi dan pasien yang patuh memiliki peluang 3,729 kali lipat dari pasien yang tidak patuh untuk mencapai keberhasilan terapi.
AKTIVITAS ANTIVIRUS EKSTRAK ETANOL BAWANG PUTIH (Allium sativum L.) TERHADAP MODEL NEWCASTLE DISEASE
Authors: Azizah Sania Nur , Saifudin Azis 
Published: December 2023

Bahan alam, baik sebagai senyawa murni atau ekstrak dari tanaman memberikan peluang sebagai agen antivirus. Bawang putih merupakan tanaman herba yang dikonsumsi di seluruh dunia yang memiliki kandungan senyawa aktif di dalamnya yang telah diteliti memiliki aktivitas farmakologi seperti antibakteri, antivirus, antijamur, antiprotozoal, antioksidan, antiinflamasi, antikanker. Senyawa aktif dalam bawang putih yang dilaporkan berperan besar sebagai antivirus yaitu ajoene, alisin, alil metil thiosulfinat, dan metil alil thiosulfinat. Penelitian bertujuan untuk mengetahui aktivitas antivirus ekstrak etanol bawang putih terhadap model Newcastle Disease. Uji antivirus dilakukan dengan media telur ayam berembrio (TAB) usia 9-12 hari yang diinokulasi virus aktif ND La Sota dan ekstrak etanol bawang putih dengan variasi konsentrasi 1 µg/mL, 10 µg/mL, dan 100 µg/mL dengan metode in ovo. Validitas uji didasarkan atas hidupnya virus yang tampak adanya kejernihan pada larutan kultur pasca perlakuan. Aktivitas antivirus dievaluasi menggunakan uji hemaglutinasi dengan bahan uji cairan alantois yang sudah dipanen untuk mendapatkan titer virus yang digunakan untuk menghitung persen penghambatan virus. Hasil menunjukkan bahwa tidak adanya aktivitas antivirus pada ekstrak dengan variasi konsentrasi 1 µg/mL, 10 µg/mL, dan 100 µg/mL dengan persen penghambatan virus ketiga seri konsentrasi 0%.
Pelatihan Canva sebagai Media Pembuatan Desain Materi Presentasi pada Siswa SMP Karitas Ngaglik
Authors: Monika Astherina Puspitasari  , Yolanda Hartin Mada  , Ezra Hasibuan  , Selly yustina  , Niken Christy Aurawidhar  
Published: December 2023

Canva merupakan salah satu aplikasi desain grafis berbasis daring yang biasa digunakan untuk media presentasi. Adanya pengenalan aplikasi Canva dapat membantu dan melatih peserta didik untuk memudahkan dalam membuat materi presentasi dengan baik. Kegiatan ini dilaksanakan di SMP Karitas Ngaglik, Nandan, Kelurahan Sariharjo, Kecamatan Ngaglik, Kabupaten Sleman, yang belum mengenal Canva. Kegiatan pengabdian masyarakat ini adalah upaya peningkatan pemahaman kepada peserta didik tentang cara membuat materi presentasi dengan baik menggunakan media Canva. Kegiatan ini dimulai dengan pemaparan materi kepada peserta didik kemudian pelatihan membuat materi presentasi dengan menggunakan Canva. Adanya pelatihan presentasi dan pelatihan menggunakan aplikasi Canva ini peserta didik diharapkan bisa menerapkannya di pembelajaran mata pelajaran yang mengharuskan presentasi dengan menggunakan media teknologi dan memanfaatkan pelatihan presentasi dengan baik. Dari hasil yang diketahui sebelum adanya pelatihan banyak peserta didik yang belum mengenal berbagai manfaat dari aplikasi Canva dan sesudah pelatihan peserta didik merasa puas dengan adanya pelatihan menggunakan aplikasi Canva serta mendapatkan pengalaman dan pengetahuan baru bagi peserta didik. Hal ini menunjukkan bahwa penggunaan aplikasi Canva bagi peserta didik sangat bermanfaat dan dapat meningkatkan keefektifan belajar bagi peserta didik.
Comparison of gut resistomes in healthy individuals and patients with severe alcoholic hepatitis
Authors: Cverenkárová Klára , Olejníková Petra , Šoltys Katarína , Messingerová Lucia , Skladaný Ľubomír , Bírošová Lucia 
Published: December 2023

Abstract
Human gut microbiota has been in the centre of scientific interest for a long period of time. Overall health status of an individual has a great impact on the composition of gut microbiota; however, gut microbiota can affect human health. Antibiotic resistance genes (ARGs) are often a part of human gut microbiome. In this paper, total genomic DNA was extracted from stool samples of 147 healthy individuals and of 45 patients with severe alcoholic hepatitis. The presence of six common ARGs (bla
TEM, bla
SHV, bla
OXA, vanA, tet(A), tet(E)) was analysed in the genomic DNA by end-point PCR. The results show significantly higher occurrence of ARGs in the DNA samples from patients (p = 0.0001) showing multiple ARGs significantly more often than in healthy individuals (p = 0.00003). Antibiotic treatment in patients strongly correlated with the occurrence of ARGs (p = 0.0038). Nutrition and sex of healthy individuals did not have significant effect on the occurrence of ARGs (p = 0.156; p = 0.456). ARGs’ occurrence in healthy individuals was the highest in the oldest age group, but the age of individuals and ARGs’ occurrence were not related (p = 0.617). In conclusion, the results underline the importance of health for normal functioning of gut microbiota. Antibiotic resistance represents a challenge in the treatment of patients with liver diseases.
Changes of Serum Angiotensin Peptides, Pro-Endothelin-1 Levels in Women One Year After Preeclampsia and their Association with Cardiovascular Risk Factors
Authors: Popovski N. , Nikolov A. , Lukanov Ts. , Blazheva S. , Totev T. 
Published: December 2023

Abstract

Introduction
Women who suffered preeclampsia (PE) have two to four times higher risk for development of cardiovascular disease (CVD) compared with women with a history of normotensive pregnancy. Microvascular and endothelial dysfunction, mediated by different vasoactive factors have been suggested as attainable pathophysiological pathways. The study aimed to: (1) determine changes in circulating levels of key vasoactive peptides in sera of women with history of PE and in women who had a normal pregnancy 1 year after delivery and (2) investigate whether an association exists between these molecules and cardiovascular risk factors.

Materials and methods
The current research examined 32 women one year after preeclampsia (mean age 25.3 ± 6.3 years) and control group of 20 women one year after normal pregnancy (mean age 25.6 ± 5.6 years). The enzyme-linked immunosorbent assay (ELISA) was used to determine serum levels of angiotensin II (AngII), angiotensin-(1-7) [Ang-(1-7)] and pro-endothelin-1 (Pro-ET-1).

Results
We found that at 1 year after delivery 38.46% of women who suffered PE have developed hypertension and 5.77% have developed diabetes mellitus. Women who had normal pregnancy developed neither hypertension, nor diabetes mellitus 1 year after delivery. Serum AngII levels in women one year after PE were statistically significantly lower than in women one year after normotensive pregnancy 0.9 (0.55÷1.7) vs. 2.3 pg/ml (2.0 ÷ 2.9) (KW = 20.849; p = 0.0001). Ang-(1-7) concentrations in women one year after PE were lower than in women one year after normal pregnancy, but not significantly 1.7 (0.3÷4.5) vs. 3.2 ng/ml (0.2÷8.0) (p>0.05). Levels of serum Pro-ET-1 in women one year after PE were statistically significantly higher than in women one year after normal pregnancy 322.65 (261.75÷391.85) vs. 248.7 pmol/L (231.05÷282.15) (KW = 6.639; p = 0.009). AngII showed correlation with AH grade (r = -0.33; 0.02), Ang-(1-7) (r = 0.27; 0.05), DBP (r = -0.28; p = 0.04), mean arterial pressure (r = -0.43; p = 0.002), pulse pressure (r = -0.28; p = 0.04), BMI (r = -0.30; p = 0.03), TC (r = -0.31; p = 0.03) and LDL (r = -0.30; p = 0.03). Pro-ET-1 correlated with age (r = 0.30; p = 0.03), mean arterial pressure (r = -0.25; p = 0.05) and pulse pressure (r = 0.41; p = 0.003).

Conclusion
Our data showed an association between key vasoactive peptides and major CVD risk factors in women one year after PE. We suggest that imbalance between AngII, Ang-(1-7) and Pro-ET-1 could have a potential imply on the vascular wall after PE, reflecting persistent microvascular and endothelial injury/dysfunction postpartum. Further studies are warranted to clarify these vasoactive peptides’ role in the ongoing vascular endothelial function after delivery and the pathogenic mechanisms determining development of CVD in previously PE women.
Role of Electrophysiologal Studies for Detection of Simulation and Aggravation in Ophthalmology
Authors: Mermeklieva E. 
Published: December 2023

Abstract

Objective
To present the importance of the electrophysiological studies for detection of malingering and aggravation in ophthalmology.

Materials and methods
Six eyes of three patients underwent a complete clinical examination, fundus-autofluorescence (FAF), fluorescein angiography (FA), optical coherence tomography (OCT), visual field testing, electrophysiological (EF) studies – full-field, multifocal and pattern electroretinography (ffERG, mfERG and PERG) and visual evoked potentials (VEPs), for detection of simulation or aggravation.

Results
After the electrophysiological studies’ results, which are objective and non-manipulable, we purposefully reviewed and repeated some of the tests already done, which allowed a comprehensive interpretation of the results. It turned out that discrete changes in targeted search can be detected in several of the studies performed, which greatly facilitates the correct diagnosis.

Conclusion
EF studies are objective methods for studying the visual analyzer’s function, that can not be manipulated, which makes them indispensable for detecting simulation and aggravation in ophthalmology. A detailed extensive study of the degree of simulation and aggravation among the ophthalmological patients is needed, which will enrich our knowledge and make us more precise in our expertise.
The immunohistochemical response of the rat periodontal ligament endothelium to an inflammatory stimulus
Authors: Toms Andrew , Gannon Bren , Carati Colin 
Published: December 2023

Abstract
Recently, inflammation has been recognised as an important co-requisite to orthodontic tooth movement. When such a reaction is initiated, the process of up-regulation of certain adhesion molecules may occur, resulting in the extravasation of leukocytes. This may stimulate progenitor/precursor pathways and signals that regulate the biological responses resulting in tooth movement. We propose that up-regulation of leukocyte adhesion molecules occurs in response to orthodontic forces, resulting in circulating monocyte attraction, extravasation and differentiation into osteoclasts, which are responsible for bone resorption that results in orthodontic tooth movement. To investigate this hypothesis, it is necessary to determine whether periodontal ligament (PDL) endothelium responds to inflammatory stimuli as other organs do. We studied the normal distribution of endothelial adhesion molecule ICAM-1 within PDL vessels, and then the following exposure to an inflammatory endotoxin. The rat PDL blood vessels expressed ICAM-1 in response to the inflammatory stimulus, similar to other organs, suggesting that the inflammatory responses are similar. Whether and where in the PDL microvascular bed orthodontic forces cause up-regulation of ICAM-1 needs to be established.
Anterior open-bite malocclusion: stability of maxillary repositioning using rigid internal fixation
Authors: Arpornmaeklong Premjit , Heggie Andrew A. C. 
Published: December 2023

Abstract
A retrospective cephalometric study was performed to investigate the stability of 37 non-growing anterior open-bite cases using mini-plate rigid fixation. The sample was divided into two groups: Group A: maxillary repositioning alone (17 cases) and Group B: bimaxillary surgery (20 cases). Tracings were performed pre-operatively (T1), immediately post-operatively (T2) and at a minimum of one year follow-up (T3) (12–90 months).
In Group A, the maxilla was advanced (3.8 +_ 2.8 mm, p < 0.01) and superiorly repositioned at PNS (2.8 +_2.3 mm, p < 0.001). In Group B, the maxilla was advanced (3.5 +_ 3.0 mm, p < 0.01) and superiorly repositioned at PNS (3.7 +_ 1.8 mm, p <0.001); and the mandible (11.7 +_ 3.8 mm, p < 0.001), with no significant change in the vertical plane (p > 0.05).
Late relapse due to condylar remodelling or resorption was found as a cause of large horizontal relapse (8.0 < x < 14.0 mm) in three cases (15%), the amount being associated with the amount of operative advancement (r = 0.7, r-sq = 40%, p < 0.01).
It was concluded that the correction of anterior open bite by posterior repositioning of the maxilla using rigid fixation is a stable procedure during the follow-up period, and that in bimaxillary cases, post-operative stability depends largely on the stability of the mandibular advancement, which in turn relates to the amounts of advancement, the pre-operative anterior open bite and the mandibular plane angle.
A comparison of two methods of assessing orthodontic treatment need in the mixed dentition: DAI and IOTN
Authors: Johnson Mark , Harkness Michael , Crowther Paul , Herbison Peter 
Published: December 2023

Abstract
This paper assesses the unmet orthodontic treatment need in a random sample of 10-year-old schoolchildren, using two indices: the Dental Aesthetic Index (DAI) and the Index of Orthodontic Treatment Need (IOTN). The DAI scores were adjusted by omitting the missing teeth component of the index because many children were in the mixed dentition with unerupted permanent teeth. Although both indices assessed the same number of children with malocclusions requiring orthodontic treatment, not all were ranked similarly by each index.
Ultrastructural identification of cells involved in the healing of intramembranous bone grafts in both the presence and absence of demineralised intramembranous bone matrix
Authors: Chay Siew Han , Rabie A. Bakr M. , Itthagarun Anut 
Published: December 2023

Abstract
Alveolar bone defects are conditions that impede the progress of orthodontic treatment. This study compared the mechanics of the healing of autogenous intramembranous (IM) bone grafts and grafts comprising a mixture of IM and demineralised bone matrix of autogenous intramembranous origin (DBMIM), in an attempt to determine the reliability of each material. Thirty-two New Zealand white rabbits had a single defect created in their skull. Sixteen were grafted with IM bone alone (Group I: autogenous IM), and the other 16 had a combined graft of composite IM sandwiched between two layers of DBMIM (Group II: composite IM-DBMIM). A third group (Group III) of eight rabbits each had two defects created in their skull; one defect was left empty (A: passive control) and the other filled with rabbit-skin collagen (B: active control). In Groups I and II, inflammatory cells were found to be present on Days 1 and 2 of tissue retrieval. The appearance of the mesenchymal cells and preosteoblasts, osteoblasts and osteocytes was earlier (Day 3) in Group II than in Group I (Day 5). In both groups, preosteoblasts, osteoblasts and osteocytes were observed with no cartilage at the intermediate stage. In conclusion, autogenous IM bone grafts and IM bone grafts in the presence of DBMIM healed through an osteogenic ossification route.
Ultrastructural changes in postcapillary-sized venule morphology in aged mouse periodontal ligament
Authors: Cameron J. , Sims M. R. , Sampson W. J. 
Published: December 2023

Abstract
The aim of this study was to compare the postcapillary-sized venule (PCV) morphology of four young ALCA mice (35 days) and four colony-related aged mice (365 days) using the transmission electron microscope (TEM). Right and left mandibular first molar mesial roots with associated periodontal ligament (PDL) and bony socket, were used for TEM assessment. Five PCV profiles were selected at each 160µm interval, from the alveolar crest to the tooth apex. PCV profile dimensions were measured on standardised micrographs magnified x2900. Age affects were tested using multiple regression analysis. The number of PCV profiles in the tooth third of the PDL was higher in aged mice (p < 0.01) and comprised predominantly apericytic vessels (p < 0.001). The number of PCV profiles increased significantly (p < 0.001) in aged mice in the PDL middle circumferential third halfway down the molar root. Age had no significant affect on PCV diameter. Aged PDL permeability studies are needed to investigate whether the changes in aged PCV profile number are associated with functional modification of the PDL microvasculature.
The localisation of ED1 antibody in the resorbing hard tissues of the periodontium
Authors: Dreyer C.W. , Pierce A.M. 
Published: December 2023

Abstract
A dental hard tissue resorptive model was used to determine the periodontal ligament (PDL) distribution of lysosomal membrane antibody ED1 to cells of the macrophage-phagocyte lineage. Immunolabel was identified in mononuclear cells around inflammatory sites in the PDL, while multinu-clear cells were labelled in resorption bays present in both bone and dentine. As repair of the tissues occurred, the label became less obvious. The presence of strong ED1 label in alveolar bone marrow provided evidence supporting the haemopoietic origin of the similarly labelled PDL cells. Also, evidence confirming the current theory that multinucleated resorptive cells differentiate along a monocyte-macrophage pathway was provided. It was concluded that ED1 is a positive PDL marker for mononuclear and multinuclear cells involved in the inflammatory and resorptive processes.
Induced mandibular condylar growth in a sheep model after functional appliance treatment
Authors: Ma Bingkui , Sampson Wayne , Fazzalari Nicola , Wilson David , Wiebkin Ole 
Published: December 2023

Abstract
This paper reports on changes in mandibular condylar growth in sheep fitted with experimental functional appliances. The paper also addresses the similarities of mandibular condylar growth in sheep and humans. Experimental functional appliances were developed, constructed and applied to four, four-month old, male sheep. Another four sheep served as matched controls. All animals received fluorochrome bone labels during the study and their weight gain also was recorded. Fifteen weeks later, all animals were sacrificed and each temporo-mandibular joint and left metacarpus were removed. Undecalcified mid-sagittal sections of the joint and metacarpus were prepared for fluorescence microscopy. The mandibular condylar growth vector in sheep was found to be in a postero-superior direction. Condylar growth in the control sheep during the experimental period varied from 8.8 to 11.9 mm, with the mean being 10.6 mm, which is quantitatively similar to two years of condylar growth in human adolescents. In the experimental sheep, the condylar growth varied from 8.5 to 13.3 mm, with the mean being 11.4 mm. When metacarpal growth and weight gain were taken into consideration using multivariant analysis, the coefficients for growth in the postero-superior and posterior direction were found to be high, with adjusted r2 as 0.84 and 0.82 respectively. The induced condylar growth was estimated to be largest in the posterior direction (2.30 mm), which is also similar to previous reports in humans. These findings suggest the appropriateness of using sheep as a model for quantitative histological analysis when investigating the mechanisms of functional appliance treatment.
Temporary tongue thrust: failure during orthodontic treatment
Authors: Piyapattamin Thosapol , Soma Kunimichi , Hisano Masataka 
Published: December 2023

Abstract
This report presents the case of a 25-year-old male patient who sought orthodontic treatment. Oral examination revealed an Angle Class I relation, with a bimaxillary dento-alveolar protrusion, evidence of anterior crowding, and a large overbite and overjet. Radiographic examination revealed a skeletal Class I occlusion. During the distal movement of the canines, occlusal interferences between the canines occurred and the commencement of a tongue thrust was observed. After correction of the applied forces, the canine movement was completed and the habit was no longer detectable. The incident indicates that an unusual oral habit suspiciously occurring during treatment should lead to an immediate reconsideration of the orthodontic treatment strategy.