bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal range of lymph node dissection in patients with unilateral papillary thyroid carcinoma with lateral cervical lymph node metastasis
Authors: Zhang Liang , Ding Zhaoming , Han Jihua , Bi Wen , Nie Chunlei 
Published: December 2023

BackgroundWhether patients with unilateral papillary thyroid carcinoma (PTC) with lateral cervical lymph node metastasis (LLNM) require prophylactic central regional lymph node dissection (CLND) remains unclear. Herein, we investigated the independent risk factors associated with contralateral central lymph node metastasis (cCLNM) in unilateral PTC with LLNM and analyzed the optimal extent of lymph node dissection by comparing the 5-year recurrence-free survival rates.Materials and methodsWe retrospectively analyzed 695 patients with unilateral papillary thyroid carcinoma and lateral cervical lymph node metastasis. Factors including sex, age, multifocal, location of primary tumor, tumor diameter, capsule invasion, thyroid nodular goiter, Hashimoto thyroiditis, ipsilateral central lymph node metastasis(iCLNM), and lateral cervical lymph node metastasis were analyzed using univariate and multivariate logistic regression analyses to explore the independent risk factors of cCLNM. Propensity scores were matched to compare the 5-year recurrence-free survival rates in patients divided by different lymph node metastases and dissections.ResultsOf all patients who underwent bilateral (b)CLND, 52% (149/286) had cCLNM. Receiver operating characteristic (ROC) curve analysis was performed on 286 patients who underwent bCLND, for which a tumor diameter of 20.5 mm and number of LLNM of 3.5 were used as the thresholds for predicting cCLNM. The 5-year recurrence-free survival (RFS) rates in the cCLN-negative and cCLN-positive groups were 98.6% and 91.2%, with statistically significant differences (P=0.034). The 5-year RFS rates showed no significant difference between the ipsilateral (i)CLND and bCLND groups (P=0.235). Multifactorial regression analysis showed that tumor diameter &gt;2 cm, presence of iCLNM, and number of LLNM &gt;3 were independent risk factors of cCLNM.But male sex, young age (&lt;45 years), multifocality, location of primary tumor, capsule invasion, thyroid nodular goiter, and Hashimoto thyroiditis were not associated with cCLNM.ConclusionNot all unilateral PTC with LLNM require prophylactic cCLND; however, prophylactic cCLND is necessary in cases which display high-risk factors for cCLNM, including primary diameter &gt;2 cm, iCLNM, and number of LLNM &gt;3.
Machine learning predictive models for grading bronchopulmonary dysplasia: umbilical cord blood IL-6 as a biomarker
Authors: Gao Linan , Yang Pengkun , Luo Chenghan , Lei Mengyuan , Shi Zanyang , Cheng Xinru , Zhang Jingdi , Cao Wenjun , Ren Miaomiao , Zhang Luwen , Wang Bingyu , Zhang Qian 
Published: December 2023

ObjectivesThis study aimed to analyze the predictive value of umbilical cord blood Interleukin-6 (UCB IL-6) for the severity-graded BPD and to establish machine learning (ML) predictive models in a Chinese population based on the 2019 NRN evidence-based guidelines.MethodsIn this retrospective analysis, we included infants born with gestational age &lt;32 weeks, who underwent UCB IL-6 testing within 24 h of admission to our NICU between 2020 and 2022. We collected their medical information encompassing the maternal, perinatal, and early neonatal phases. Furthermore, we classified the grade of BPD according to the 2019 NRN evidence-based guidelines. The correlation between UCB IL-6 and the grades of BPD was analyzed. Univariate analysis and ordinal logistic regression were employed to identify risk factors, followed by the development of ML predictive models based on XGBoost, CatBoost, LightGBM, and Random Forest. The AUROC was used to evaluate the diagnostic value of each model. Besides, we generated feature importance distribution plots based on SHAP values to emphasize the significance of UCB IL-6 in the models.ResultsThe study ultimately enrolled 414 preterm infants, with No BPD group (n = 309), Grade 1 BPD group (n = 73), and Grade 2–3 BPD group (n = 32). The levels of UCB IL-6 increased with the grades of BPD. UCB IL-6 demonstrated clinical significance in predicting various grades of BPD, particularly in distinguishing Grade 2–3 BPD patients, with an AUROC of 0.815 (95% CI: 0.753–0.877). All four ML models, XGBoost, CatBoost, LightGBM, and Random Forest, exhibited Micro-average AUROC values of 0.841, 0.870, 0.851, and 0.878, respectively. Notably, UCB IL-6 consistently appeared as the most prominent feature across the feature importance distribution plots in all four models.ConclusionUCB IL-6 significantly contributes to predicting severity-graded BPD, especially in grade 2–3 BPD. Through the development of four ML predictive models, we highlighted UCB IL-6's importance.
Gongying-Jiedu-Xiji recipe promotes the healing of venous ulcers by inhibiting ferroptosis via the CoQ-FSP1 axis
Authors: Lu Yongpan , Zhao Dejie , Liu Ming , Cao Guoqi , Liu Chunyan , Yin Siyuan , Song Ru , Ma Jiaxu , Sun Rui , Wu Zhenjie , Liu Jian , Wang Yibing 
Published: December 2023

Objective: Gongying-Jiedu-Xiji recipe (DDL, batch number Z01080175) reduces body temperature, detoxifies, activates the blood circulation, reduces swelling, and dispels decay and pus. The aim of this study was to investigate the mechanism of action by which DDL functions in the treatment of venous ulcers (VUs).Methods: Normal tissues as well as VU tissues before and after DDL treatment were collected from nine VU patients in the hospital with ethical approval. These three tissues were subjected to Prussian blue iron staining, immunoblotting, immunohistochemistry, immunofluorescence, and quantitative real-time PCR to detect the expression of ferroptosis suppressor protein 1 (FSP1), coenzyme Q (CoQ), 4-hydroxynonenal (4-HNE), and glutathione peroxidase 4 (GPX4). After successful validation of the heme-induced human foreskin fibroblast (HFF) ferroptosis model, lyophilized DDL powder was added to the cells, and the cells were subjected to viability assays, immunoblotting, flow cytometry, glutathione (GSH) and malonaldehyde (MDA) assays, electron microscopy and qPCR assays.Results: Ferroptosis in VU tissues was stronger than that in normal tissues, and ferroptosis in VU tissues after DDL treatment was weaker than that before treatment. Inhibition of CoQ and FSP1 and transfection of FSP1 influenced the effects of DDL.Conclusion: Our results suggest that DDL may promote healing by attenuating ferroptosis in VUs and that DDL may promote VU healing by modulating the CoQ-FSP1 axis.
Health disparities in preterm births
Authors: Brown Judy , Chang Xiaolin , Matson Adam , Lainwala Shabnam , Chen Ming-Hui , Cong Xiaomei , Casavant Sharon G. 
Published: December 2023

IntroductionBlack African American (B/AA) women have a 2-fold to 3-fold elevated risk compared with non-Hispanic White (W) women for preterm birth. Further, preterm birth is the leading cause of mortality among B/AA infants, and among survivors, preterm infant adverse health outcomes occur disproportionately in B/AA infants. Racial inequities in maternal and infant health continue to pose a public health crisis despite the discovery &gt;100 years ago. The purpose of this study was to expand on reported preterm infant outcome disparities. A life-course approach, accumulation of lifelong stress, including discrimination, may explain social factors causing preterm birth rate and outcome inequities in B/AA mothers.MethodsAnthropometric measures and clinical treatment information for 197 consented participants were milled from electronic health records across 4 years. The Neonatal Infant Stressor Scale was used to tally acute and chronic painful/stressful procedures. Neurobehavioral differences were investigated using the Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale.ResultsB/AA mothers gave birth to preterm infants earlier than W mothers. NICU hospitalization stays were extended more than 2 weeks for the significantly smaller B/AA preterm infants in comparison to the age-matched W preterm infants. A higher number of chronic lifesaving procedures with demonstrated altered stress response patterns were recorded for B/AA preterm infants.DiscussionThis cross-sectional analysis of preterm birth rates and preterm infant developmental and neurodevelopmental outcomes are presented in the context of NICU stress and pain, with attendant implications for infant mortality and future health disparities. Preterm birth rate and outcome inequities further support the need to develop interventions and policies that will reduce the impact of discrimination and improve social determinants of health for Black, Indigenous, and other People of Color.
Nurses’ perception of work and life under COVID-19 pandemic conditions: a qualitative study
Authors: Maghsoodi Esmaiel , Vanaki Zohreh , Mohammadi Eesa 
Published: December 2023

ObjectivesAlthough nurses work and live in special and stressful conditions due to the nature of their profession, in periods of crises and pandemics, when the work pressure on nurses and the public’s need for professional services increases to extraordinary and incomparable levels compared to customary conditions, their work and life situation becomes entirely different. Therefore, what nurses experienced in the COVID-19 pandemic went beyond the typical challenges of their work environment. This study was conducted to discover nurses’ perceptions of work and life during the COVID-19 pandemic.MethodsThis qualitative study was conducted with a conventional content analysis approach on 16 nurses working in the inpatient wards during the COVID-19 pandemic in Iran. Data were collected through unstructured, individual, and in-depth interviews between August 2020 and June 2023 and were analyzed using content analysis with the conventional (inductive) approach of Granheim and Lundman.ResultsData analysis led to the extraction of 11 subcategories, namely, “feeling a lack of support and understanding from managers,” “team cooperation and communication challenges in difficult work conditions,” “shadow of burnout,” “shortage inequity,” “dissatisfaction with unfair wages and benefits,” “not having their work and sacrifices appreciated,” “suffering and fatigue of using personal protective equipment (PPE),” “deprivation of entertainment and rest,” “fear of illness and imminent death,” “low resilience,” and “deteriorating life conditions” These 11 subcategories led to the following themes: “unsafe work environment” and “the shadow of suffering and death.”ConclusionNurses working in COVID-19 wards in Iran worked in an unsafe work environment during the COVID-19 pandemic and had to deal with suffering and fear of death. It is necessary to pay attention to the needs and problems of nurses, and healthcare organizations must provide the required support to maintain the physical and mental health of nurses during epidemics.
Gender mainstreaming in sweetpotato breeding in Uganda: a case study
Authors: Ssali Reuben T. , Mayanja Sarah , Nakitto Mariam , Mwende Janet , Tinyiro Samuel Edgar , Bayiyana Irene , Okello Julius , Forsythe Lora , Magala Damalie , Yada Benard , Mwanga Robert O. M. , Polar Vivian 
Published: December 2023

PurposeIn Uganda, sweetpotato [Ipomoea batatas (L.) Lam] is typically a “woman’s crop,” grown, processed, stored and also mainly consumed by smallholder farmers for food and income. Farmers value sweetpotato for its early maturity, resilience to stresses, and minimal input requirements. However, productivity remains low despite the effort of breeding programs to introduce new varieties. Low uptake of new varieties is partly attributed to previous focus by breeders on agronomic traits and much less on quality traits and the diverse preferences of men and women in sweetpotato value chains.MethodTo address this gap, breeders, food scientists, and social scientists (including gender specialists) systematically mainstreamed gender into the breeding program. This multidisciplinary approach, grounded in examining gender roles and their relationship with varietal and trait preferences, integrated important traits into product profiles.ResultsBuilding on earlier efforts of participatory plant breeding and participatory varietal selection, new interventions showed subtle but important gender differences in preferences. For instance, in a study for the RTBFoods project, women prioritized mealiness, sweetness, firmness and non-fibrous boiled roots. These were further subjected to a rigorous gender analysis using the G+ product profile query tool. The breeding pipelines then incorporated these gender-responsive priority quality traits, prompting the development of standard operating procedures to phenotype these traits.ConclusionFollowing an all-inclusive approach coupled with training of multidisciplinary teams involving food scientists, breeders, biochemists, gender specialists and social scientists, integration into participatory variety selection in Uganda enabled accentuation of women and men’s trait preferences, contributing to clearer breeding targets. The research has positioned sweetpotato breeding to better respond to the varying needs and preferences of the users.
Growth, Substrate, and Metabolite Changes of Probiotic Bifidobacterium animalis subsp. lactis in Soy (Tofu) Whey
Authors: Tindjau Ricco , Chua Jian-Yong , Liu Shao-Quan 
Published: December 2023

Soy (tofu) whey is one of the two side-streams from tofu processing, which has been shown to be suitable for microbial growth. In this work, probiotic Bifidobacterium animalis subsp. lactis Bl-04 and B94 were used to ferment soy whey with different supplements to explore the possibility of harnessing Bifidobacterium fermentation to upcycle soy whey. Soy whey was supplemented with different supplements (control, CN; glucose, G; glucose + cysteine, GC; glucose + cysteine + yeast extract, GCY) and inoculated with either B. lactis Bl-04 or B94. Growth, substrate utilization, and metabolic products were monitored before and after fermentation. Bl-04 managed to grow in all four media, while B94 needed cysteine to grow. The contents of sucrose, cysteine, methionine, and succinic acid decreased in the fermented samples. Acetic and lactic acids were produced in fermented soy whey ranging from 0.49–2.66 g/L and 0.58–2.88 g/L, respectively, with vitamin B12 at 2.06–4.56 μg/L. Increases in isoflavone aglycones (0.19–25.05 mg/L) and iron (0.03–0.12 mg/L) were observed. The PCA analysis of volatiles showed a distinct clustering due to short-chain fatty acids (acetic, butyric, and isovaleric acid), 2,3-butanedione (diacetyl), H2S, and 3-methylthiophene. Overall, the selection of suitable bifidobacterial strains and supplements for soy whey fermentation can open avenues to upcycle soy whey.
METHODS OF SYNTHESIS OF SILICATE-CONTAINING CLINKER DENTAL CEMENT
Authors: Mishin D. , Doroganov V. , Dolgova E. , Tarallo Z. , Evtushenko E. , Lukin E. 
Published: December 2023

The article provides an overview of modern cements used in dentistry with an emphasis on silicate cements such as mineral trioxide aggregate (MTA). The basic requirements for dental cements are given, including their safety, adhesion to tooth tissues, resistance to various influences and thermal properties.
The article analyzes in detail the composition and properties of industrial white Portland cement used in construction, in comparison with the characteristics of dental silicate cements. The general issues of the synthesis of high-base calcium silicates used in dentistry are considered from the standpoint of the chemical technology of Portland cement. The mineralogical composition and hydration processes of various cement components, their effect on tooth color and other properties are discussed.
The methods of reducing the temperature and increasing the rate of formation of calcium silicates, common in the technology of dental cements and in the production of Portland cement, are indicated. It is assumed that it is possible to accelerate solid-phase synthesis in the range of 1250-1350 °C with a special method of introducing mineralizers proposed at the V.G. Shukhov BSTU for the synthesis of white Portland cement, provided it is adapted for dental formulations.
Le développement de la force et de la vitesse de raccourcissement musculaire chez les enfants et les adolescents des deux sexes
Authors: Gerbeaux Michel , Pertuzon Emile , Mereaux M. , Rousseau Jean 
Published: December 2023

A partir d’une sélection de 40 enfants de 6 à 24 ans, et par des méthodes non-invasives, nous avons tracé la cinétique de l’évolution de la force et de la vitesse de raccourcissement musculaire.
Les garçons progressent brusquement en vitesse pendant la prépuberté et en force pendant la puberté, alors que la force et la vitesse chez les jeunes filles progressent d’une façon strictement linéaire.
Ce type d’appareillage doit permettre l’approche de la notion «d’âge moteur».
Essai d'analyse sociographique de différents champs de publication de certains bulletins et revues associatifs du champ des pratiques d'exercice corporel
Authors: Joseph Robert 
Published: December 2023

Les savoirs qui s’amassent, s’assemblent, se construisent, dans le champ des pratiques d’exercice corporel sont véhiculés et diffusés, la plupart du temps, par des bulletins et revues d’association. Des champs de diffusion et d’échange sont organisés en fonction de trois grands types de savoir, technique, pédagogico-didactique et scientifique. Les changements institutionnels donnent lieu à des restructurations de ces champs de diffusion qui suscitent des vocations et des organisations de véhicules de publication nouveaux qui peuvent être des lieux de repérage de groupes sociaux institutionnalisés.
C’est par une analyse thématique de contenu de presse complète et détaillée, et à partir d’un corpus de revues significatives du champ des savoirs des pratiques d’exercice corporel que nous avons pu confirmer notre hypothèse dans un contexte de recherche sociographique.
Les savoirs techniques, premières formes de rationalisation des exercices et pratiques corporels et sportifs, sont diffusés par les revues les plus anciennes. Les savoirs pédagogiques détiennent un autre champ de diffusion et d’échange de revues anciennes mais les didactiques suscitent aujourd’hui des revues nouvelles. Actuellement, les savoirs scientifiques permettent des vocations à édition.
Mais ces champs de diffusion ne sont-ils pas aussi des champs de concurrences ?
«Métamorphoses d'une revendication corporelle : du corps libéré au corps obéissant»
Authors: Barreau Jean-Michel 
Published: December 2023

Ni maître, ni chef, ni adulte. Le discours non-directif des années soixante et soixante-dix a violemment contesté toute figure d’autorité, notamment sur le corps. Les rogériens, bio-énergéticiens, et autres animateurs de groupes, devaient se substituer aux pédagogues «traditionnels», trop autoritaires.
Mais, ces animateurs non-directifs n’ont pas supprimé l’autorité. Ils l’ont métamorphosée. Car, s’ils ne sont pas contraignants, ils sont excellents. Ce sont des magisters. Ils analysent tout, comprennent tout. De plus, ils prônent la morale de l’hédonisme mais, paradoxalement, nous les retrouverons hédonistes-autocrates puis autocrates-tout-court.
Effort et trisomiques 21 : descriptif de quelques réponses métaboliques lors de l’activité physique
Authors: Eberhard Yves , Eterradossi Jacqueline 
Published: December 2023

Les objectifs de cette étude sont de connaître les possibilités d’adaptations à l’effort chez les Trisomiques 21 de manière à savoir si l’effort a chez eux des répercussions métaboliques favorables ou défavorables.
Pour cela, 11 sujets (garçons et filles de 15 à 20 ans) trisomiques 21 (T21), en bonne santé, originaires de la région grenobloise ont participé à une expérimentation.
Après une période de mise en condition physique et de familiarisation avec les techniques d’effort en laboratoire, un profil de réponses métaboliques a été estimé avant et après 2 exercices sur cycloergomètre : 1 Monogramme, les substrats, les catécholamines, les lipoprotéines du plasma ont été dosés avant et après 1 exercice maximal de courte durée et 1 exercice d’endurance de 40 minutes. De même un dosage de la superoxyde dismutase (SOD-1) dans les globules rouges a été réalisé en fin d’effort.
Les résultats montrent :
a) un lactate sanguin à l’exercice maximal peu augmenté,
b) une lente mobilisation des AGL au début de l’exercice,
c) un profil lipidique de repos soulignant un niveau de cholestérol HDL faible et un haut niveau de prébêta VLDL,
d) un ajustement presque normal de ces profils lipidiques sous l’effet de l’activité d’endurance, (e) des différences dans les valeurs de SOD-1 entre les T21 sédentaires et les T21 entraînés.
Ces résultats suggèrent que les adolescents T21 sont capables d’un certain niveau de performance dans l’exercice physique.
Les modifications constatées à la suite d’un exercice de longue durée en faveur d’une normalisation du profil lipidique, engagent à vérifier si une activité physique régulièrement pratiquée permet d’obtenir une amélioration stable de leur bilan lipidique au repos.
Un nouvel abord psychologique de la performance : la relaxation
Authors: Léonard Jean-Raymond 
Published: December 2023

La préparation psychologique du sportif s’inscrit dans une logique de la réussite que l’athlète reconnaît comme facteur déterminant dans la réalisation de la performance. Ici, la relaxation, présentée dans ses aspects théoriques est ensuite mise à l’épreuve dans une application pratique auprès d’un triathlonien durant 24 heures, champion du monde.
La relaxation élargit donc le champ du possible chez l’athlète, lui permettant d’accéder, dans l’espace potentiel à une frange subconsciente de sa personne et de mobiliser des ressources nouvelles.
La préparation au mouvement dans le cadre des praxies motrices complexes : Rôle spécifique de l'aire motrice supplémentaire
Authors: De Jaeger Dominique , Schepens-Boisacq Nicole 
Published: December 2023

Cet article tente de synthétiser d’une manière cohérente les données expérimentales récemment acquises dans le domaine des processus neurophysiologiques préalables et sous-jacents au mouvement, en se centrant sur la contribution spécifique de l’aire motrice supplémentaire (A.M.S.). Parmi les résultats retenus, certains sont issus d’expériences classiques chez l’animal (stimulations et lésions d’aires corticales), d’autres ont été obtenus grâce à des techniques plus sophistiquées d’observation et d’enregistrement, appliquées tant chez l’homme que chez l’animal. Les techniques récemment développées permettent, en effet, de mettre en évidence les structures corticales plus spécifiquement impliquées dans l’une ou l’autre phase de la préparation motrice. Ainsi, s’agissant de la programmation des séquences motrices complexes apprises - telles que mises en oeuvre en gymnastique sportive -, les données soulignent le rôle de l’aire motrice supplémentaire (A.M.S.) : son interaction fonctionnelle, déjà apparente dans les études morphologiques, structurelles et d’expérimentation classique, paraît mieux précisée par les méthodes dynamiques d’enregistrement des potentiels corticaux et des variations du flux sanguin cérébral régional.
La présentation des données est suivie d’une brève discussion, débouchant sur la formulation de notre hypothèse et de quelques propositions pour la recherche future, en rapport avec l’apprentissage moteur de praxies sportives.