bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of IgG4 in systemic lupus erythematosus: Implications for pathogenesis and therapy
Authors: Liu Yanyan , Wang Yingjian , Hu Mengsi , Xu Shoufang , Jiang Feiyu , Han Yetao , Liu Zhiwei 
Published: January 2024

AbstractImmunoglobulin (Ig) G4 has a distinctive nature, and its involvement in autoimmune disorders is a subject of ongoing debate and uncertainty. A growing body of evidence indicates that IgG4 may play a pathogenic role in the development of systemic lupus erythematosus (SLE). The IgG4 autoantibodies have the capability to bind autoantigens in a competitive manner with other Ig classes, thereby forming immune complexes (ICs) that are noninflammatory in nature. This is due to the low affinity of IgG4 for both the Fc receptors and the C1 complement molecule, which results in a diminished inflammatory response in individuals with SLE. The present study aims to elucidate the significance of IgG4 in SLE. The present discourse pertains to the nascent and suggested modalities through which IgG4 might participate in the pathogenesis of SLE and the potential ramifications for therapeutic interventions in SLE.
Evaluation of mpox contact tracing activities and data collection in EU/EEA countries during the 2022 multicountry outbreak in nonendemic countries
Authors: Prins Henrieke , Coyer Liza , De Angelis Stefania , Bluemel Benjamin , Cauchi Daniel , Baka Agoritsa 
Published: January 2024

AbstractTo control human‐to‐human mpox transmission during the 2022 outbreak, European Union (EU)/European Economic Area (EEA) countries conducted case investigation and contact tracing (CT). We aimed to provide an overview of CT activities, describe CT data collection practices, and identify related facilitators, barriers, and potential opportunities for improvement. Between April 03, 2023 and May 12, 2023, a survey was distributed to CT stakeholders in 30 EU/EEA countries, asking about mpox CT activities and data collection and requesting to rank enablers, barriers, and improvements for CT on a five‐point Likert scale. The 139 respondents from 27 countries indicated having performed case investigations (96%, n = 133), backward CT (88%, n = 122), forward CT (87%, n = 121), and follow‐up on contacts' outcomes (77%, n = 107). Sixty percent (n = 80/134) used standardized data collection forms and 73% (n = 91/124) used databases. The highest‐rated enablers were clear guidelines (mean = 3.9), quick access to laboratory results (3.6), and sufficient expertise (3.6). Highly rated barriers were inability to contact contacts (3.0) or cases (2.5) and lack of staff (2.4). The most needed improvements were availability of staff (3.5), expertise on affected populations (3.4) and data reporting tools and systems (3.3). To improve CT of mpox and diseases with similar transmission patterns, EU/EEA countries should increase workforce capacity in public and sexual health, offer training on CT operations and communication with affected communities, and use common CT data collection tools and systems.
Trifluridine for treatment of mpox infection in drug combinations in ophthalmic cell models
Authors: Cinatl Jindrich , Bechtel Marco , Reus Philipp , Ott Melanie , Rothweiler Florian , Michaelis Martin , Ciesek Sandra , Bojkova Denisa 
Published: January 2024

AbstractThe Mpox virus can cause severe disease in the susceptible population with dermatologic and systemic manifestations. Furthermore, ophthalmic manifestations of mpox infection are well documented. Topical trifluridine (TFT) eye drops have been used for therapy of ophthalmic mpox infection in patients, however, its efficacy against mpox virus infection in this scenario has not been previously shown. In the present study, we have established ophthalmic cell models suitable for the infection with mpox virus. We show, that TFT is effective against a broad range of mpox isolates in conjunctival epithelial cells and keratocytes. Further, TFT remained effective against a tecovirimat‐resistant virus strain. In the context of drug combinations, a nearly additive effect was observed for TFT combinations with brincidofovir and tecovirimat in conjunctival epithelial cells, while a slight antagonism was observed for both combinations in keratocytes. Altogether, our findings demonstrate TFT as a promising drug for treatment of ophthalmic mpox infection able to overcome tecovirimat resistance. However, conflicting results regarding the effect of drug combinations with approved compounds warrant close monitoring of such use in patients.
SARS‐CoV‐2 nucleocapsid antigen in plasma of children hospitalized for COVID‐19 or with incidental detection of SARS‐CoV‐2 infection
Authors: Capelli Nicolas , Domitien Payet Léa , Alcocer Cordellat Carmen , Pisoni Amandine , Engelmann Ilka , Van de Perre Philippe , Jeziorski Eric , Tuaillon Edouard 
Published: January 2024

AbstractIn hospitalized children, SARS‐CoV‐2 infection can present as either a primary reason for admission (patients admitted for COVID‐19) or an incidental finding during follow‐up (patients admitted with COVID‐19). We conducted a nested case‐control study within a cohort of pediatric patients with confirmed SARS‐CoV‐2 infection, to investigate the concentration of plasma nucleocapsid antigen (N‐Ag) in children admitted for COVID‐19 or with COVID‐19. While reverse transcriptase polymerase chain reaction Ct values in nasopharyngeal swab were similar between the two groups, children admitted for COVID‐19 had a higher rate of detectable N‐Ag (12/18 (60.7%) versus 6/18 (33.3%), p = 0.0455) and a higher concentration of N‐Ag (medians: 19.51 g/mL vs. 1.08 pg/mL, p = 0.0105). In children hospitalized for COVID‐19, the youngest had higher concentration of N‐Ag (r = −0.74, p = 0.0004). We also observed a lower prevalence of detectable spike antibodies in children hospitalized for COVID‐19 compared to those hospitalized for other medical reasons (3/15 [20%] vs. 13/16 [81.25%], respectively, p = < 0.0011), but similar rates of IgG nucleocapsid antibodies (5/14 [35.7%] vs. 6/17 [35.3%], respectively, p = 0.99). Our findings indicate that N‐Ag is associated with COVID‐19‐related hospitalizations in pediatric patients, and less frequently detected in children tested positive for SARS‐CoV‐2 but hospitalized for another medical reason. Further studies are needed to confirm the value of N‐Ag in identifying COVID‐19 disease infections in which SARS‐CoV‐2 is the main pathogen responsible for symptoms.
Climatic factors affecting Kamchatka glacier recession
Authors: Korneva I. A. , Toropov P. A. , Muraviev A. Ya. , Aleshina M. A. 
Published: January 2024

AbstractThe reduction in the area and volume of glaciation in all mountain regions of the Earth has strongly accelerated for the last decades. In this work, we analysed the trends of the main climatic parameters which caused the glacier recession in the Kamchatka Peninsula. It was shown that the glaciers of the northern part of the Sredinny Range decreased by 125 km2 (35.6%) from 1950 to 2016–2017. The average rate of their reduction in the period from 2002 to 2016–2017 (1.45%/year) increased approximately 4.3 times compared to the period 1950–2002 (0.34%/year). The greatest reduction is observed in small glaciers with an area of less than 0.1 km2 and in glaciers with southeastern and southern expositions. On the Kronotsky Peninsula, the glacier area reduction for 1957–2019 was equal to 32.1 km2 (35.6%), and the rates were almost the same in the periods of 1957–2000 (0.61%/year) and 2000–2019 (0.67%/year). According to the data of weather stations and ERA5 reanalysis, it was shown that, in the ablation (summer) period the warming rate was minimal (0.3°C/10 years) and in the accumulation period a significant decrease in precipitation (5%–10%/10 years) was revealed in some areas. At the same time, a significant increase in the radiation balance was revealed in the warm season along with a tendency in downward shortwave radiation increase for the last two decades due to a decrease in cloud amount. These trends are in good agreement with the growth of the geopotential height over the North Pacific during the warm season in the 21st century, and with the growth of velocity divergence in the middle troposphere and the intensification of downward air movements. All this confirms an increase in anticyclone frequency in the warm season, which could be the cause of a radiation balance increase and, consequently, an increase in glacier ablation.
The impact of age, disease severity, and BMI on bone health and growth in children and young people with Crohn's disease
Authors: Kherati Rida , Bansal Archana , Oleksiewicz Julia , Kadir Ahmed , Burgess Natasha , Barr Sabrina , Naik Sandhia , Croft Nicholas M , Gasparetto Marco 
Published: January 2024

AbstractObjectivesThe objective of this study was to explore the correlation between paediatric Crohn's disease (CD) characteristics, bone health and growth parameters at diagnosis and follow‐up.MethodsRetrospective data was collected for 47 children aged 4–16 who were newly diagnosed with CD between January 2018 and December 2019. Mean follow‐up time was 2.5 years.ResultsEleven (24%) children had growth delay at diagnosis, which persisted in 4 (44%) of 9 recorded children at follow‐up. Of the 35 children tested, 20 (57%) had inadequate Vitamin D levels (<50 mmol/L) at diagnosis. Thirty‐seven (79%) children had a dual‐energy X‐ray absorptiometry scan at diagnosis, with 20 of them having at least 1 low Z‐score. Children with poorer bone mineral density and bone mineral concentration Z‐scores for age had a younger age at diagnosis (p = .042 and p = .021), more severe disease (p = .04 and p = .029) and a lower BMI (p < .001) at diagnosis. Children diagnosed with CD ≥11 years had a lower‐than‐expected height velocity (p < .0001 and p < .001). Multivariate regression analysis demonstrated an older age of diagnosis was a significant predictor of a lower height velocity at follow‐up.ConclusionDisease severity and age of diagnosis are important CD‐related factors that influence bone health and growth. Vitamin D is an accessible component that if optimised can improve all three factors. Monitoring and optimising each aspect systematically has the potential to enable children to achieve their bone health and growth potentials.
Advanced polymer‐based surfactant for improved heat and salinity stability in enhanced oil recovery processes
Authors: Soleimani Mohammad , Abdalisousan Ashkan , Manshad Abbas Khaksar , Sajadiyan Vali Ahmad 
Published: January 2024

AbstractEnhancing oil recovery through surfactants has proven to be a successful strategy in recent times. However, traditional surfactants have their limitations, particularly in terms of stability under high temperatures and salinity levels. This study delved into a groundbreaking macromolecular polymeric surfactant, S‐AV, which holds the unique ability to transform rock surface characteristics, effectively stripping away residual oil while maintaining resilience against elevated temperatures and salinity. S‐AV was synthesized through a free‐radical copolymerization process, incorporating benzyl, perfluoroalkyl, alkyl‐, benzyl‐, ethylene glycol, and amide‐alkyl‐sulfonate groups, ultimately yielding a comb‐like molecular structure. S‐AV demonstrated exceptional prowess, swiftly reducing the underwater oil contact angle to 53.4° in just 48 h. This synthesized surfactant also retained its phase stability up to salinity levels of 36,000 ppm, with temperature having no disruptive impact on its phase stability performance. Furthermore, S‐AV showcased remarkable viscosity reduction in conditions of high temperature and salinity. The core flooding experiments underscored the potential of S‐AV, as its injection led to a significant oil recovery rate of up to 83%. These findings position S‐AV as a promising candidate for practical enhanced oil recovery applications.
TGFB1I1 promotes cell proliferation and migration in urothelial carcinoma
Authors: Liang Peir‐In , Wei Yu‐Ching , Chen Huan‐Da , Ma Yu‐Chun , Ke Hung‐Lung , Chien Chu‐Chun , Chuang Hao‐Wen 
Published: January 2024

AbstractUrothelial carcinoma (UC) is common cancer worldwide with a high prevalence in Taiwan, especially in the upper urinary tract, including the renal pelvis and ureter, also classifying as upper urinary tract urothelial carcinoma. Here, we aim to find a representative prognostic marker that strongly correlates to this type of carcinoma. Transforming growth factor beta‐1‐induced transcript 1 (TGFB1I1) is a cofactor of cellular TGF‐β1 and interacts with various nuclear receptors. The previous study showed that TGFB1I1 promotes focal adhesion formation, contributing to the epithelial‐mesenchymal transition (EMT) with actin cytoskeleton and vimentin through TGFB1I1 regulation. We aim to reveal the role of TGFB1I1 in the tumorigenesis of UC. In silico and clinicopathological data of upper urinary tract urothelial carcinoma (UTUC) and urinary bladder urothelial carcinoma (UBUC) were accessed and analyzed for IHC staining regarding tumor characteristics, including survival outcome. Finally, an in vitro study was performed to demonstrate the biological changes of UC cells. In UTUC, overexpression of TGFB1I1 was significantly correlated with advanced tumor stage, papillary configuration, and frequent mitosis. Meanwhile, overexpression of TGFB1I1 was significantly correlated with advanced tumor stage and histological grade in UBUC. Moreover, the in vitro study shows that TGFB1I1 affects cell proliferation, viability, migration and wound healing. The EMT markers also decreased upon TGFB1I1 knockdown. In this study, we identified that TGFB1I1 regulates UC cell proliferation and viability and induces the EMT to facilitate cell migration in vitro, leading to its essential role in promoting tumor aggressiveness in both UTUC and UBUC.
CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR‐485‐3p‐dependent manner
Authors: Lan Zhang‐Zhang , Sun Feng‐Hua , Chen Chuan , Niu Li , Shi Jing‐Dong , Zhang Wen‐Yong 
Published: January 2024

AbstractCircular RNA (circRNA) plays a key part in the pathological process of gastric cancer (GC). The study is organized to analyze the function of circPRDM5 in GC cell tumor properties. Expression levels of circPRDM5, miR‐485‐3p, glucosaminyl (N‐acetyl) transferase 4 (GCNT4), ki67, E‐cadherin, N‐cadherin, and hexokinase 2 (HK2) were analyzed by quantitative real‐time polymerase chain reaction (PCR), Western blotting or immunohistochemistry assay. Cell proliferation was assessed by cell colony formation assay and 5‐ethynyl‐2′‐deoxyuridine assay. Cell migration and invasion were investigated by transwell assay. Glycolysis was evaluated by the Seahorse XF Glycolysis Stress Test Kit. Dual‐luciferase reporter assay and RNA pull‐down assay were performed to identify the associations among circPRDM5, miR‐485‐3p, and GCNT4. Xenograft mouse model assay was conducted to determine the effects of circPRDM5 on tumor formation in vivo. CircPRDM5 and GCNT4 expression were downregulated, while miR‐485‐3p expression was upregulated in GC tissues and cells when compared with paracancerous tissues or human gastric epithelial cells. CircPRDM5 overexpression inhibited proliferation, migration, invasion, and glucose metabolism of GC cells; however, circPRDM5 depletion had the opposite effects. CircPRDM5 repressed tumor properties of GC cells in vivo. MiR‐485‐3p restoration relieved circPRDM5‐induced effects in GC cells. GCNT4 overexpression remitted the promoting effects of miR‐485‐3p mimics on GC cell malignancy. CircPRDM5 acted as a sponge for miR‐485‐3p, and GCNT4 was identified as a target gene of miR‐485‐3p. Moreover, circPRDM5 regulated GCNT4 expression by interacting with miR‐485‐3p.CircPRDM5 acted as a miR‐485‐3p sponge to inhibit GC progression by increasing GCNT4 expression, proving a potential target for GC therapy.
A comparative analysis of laryngeal nerve damage in patients with idiopathic vocal cord paralysis exhibiting different paralytic sides
Authors: Liu Xiao‐Hong , Yan Jing , Li Na , Zhang Qing‐Qing , Xie Meng , Guo Rui‐Xin , Du Xiao‐Ying , Chen Yang‐Juan , Kong De‐Min , Yang Min‐Juan , Ren Xiao‐Yong 
Published: January 2024

AbstractObjectiveTo assess the extent of recurrent laryngeal nerve (RLN) and superior laryngeal nerve (SLN) damage in patients with idiopathic vocal cord paralysis (IVCP) exhibiting different paralytic sides.MethodsA total of 84 IVCP cases were evaluated using stroboscopic laryngoscopy, voice analysis, and laryngeal electromyography (LEMG). The results were compared between patients with left‐sided paralysis and right‐sided paralysis based on different disease courses (less than or more than 3 months).ResultsInitially, the average age and disease progression of IVCP patients were found to be similar regardless of the side of paralysis (p > .05). Additionally, there were no significant variations in voice indicators, such as MPT, DSI, and VHI, between IVCP patients with left and right vocal cord paralysis (p > .05). Furthermore, no disparities were detected in the latencies and amplitudes of the paralyzed RLN and SLN, as well as the durations and amplitudes of the action potentials in the paralyzed TM and PCM, among IVCP patients with left and right vocal cord paralysis (p > .05). Notably, the amplitudes of the left paralytic CM were significantly lower than those of the right paralytic CM (0.45 vs. 0.53, Z = −2.013, p = .044). In addition, no disparities were observed in APDs and amplitudes between the ipsilateral PCM and TM, either for patients with left or right vocal fold paralysis (p > .05). Finally, all the IVCP patients were subdivided into two subgroups according to different disease course (less than or more than 3 months), and in each subgroup, the comparison of voice indicators and LEMG results in IVCP patients with left or right vocal fold paralysis were similar with the above findings (p > .05).ConclusionOverall, the degree of RLN and SLN damage appeared to be similar in IVCP patients with left and right vocal cord paralysis, provided that the disease course was comparable.Level of Evidence4.
Hydrophilic, Porous, Fiber‐Reinforced Collagen‐Based Membrane for Corneal Repair
Authors: Li Zhi‐Biao , Liu Jia , Xu Ying‐Ni , Sun Xiao‐Min , Peng Yue‐Hai , Zhao Qi , Lin Yong‐An , Huang Yong‐Rui , Ren Li 
Published: January 2024

AbstractCollagen membrane with outstanding biocompatibility exhibits immense potential in the field of corneal repair and reconstruction, but the poor mechanical properties limit its clinical application. Polycaprolactone (PCL) is a biodegradable polymer widely explored for application in corneal reconstruction due to its excellent mechanical properties, biocompatibility, easy processability, and flexibility. In this study, a PCL/collagen composite membrane with reinforced mechanical properties is developed. The membrane has a strong composite structure with collagen by utilizing a porous and hydrophilic PCL scaffold, maintaining its integrity even after immersion. The suture retention and mechanical tests demonstrate that compared with the pure collagen membrane, the prepared membrane has a greater tensile strength and twice the modulus of elasticity. Further, the suture retention strength is improved by almost two times. In addition, the membrane remains fully intact on the implant bed in an in vitro corneal defect model. Moreover, the membrane can be tightly sutured to a rabbit corneal defect, progressively achieve epithelialization, and remain unchanged during observation. Overall, the PCL/collagen composite membrane is a promising candidate as a suturable corneal restoration material in clinical keratoplasty.
Engaging consumers through artificially intelligent technologies: Systematic review, conceptual model, and further research
Authors: Hollebeek Linda D. , Menidjel Choukri , Sarstedt Marko , Jansson Johan , Urbonavicius Sigitas 
Published: January 2024

AbstractWhile consumer engagement (CE) in the context of artificially intelligent (AI‐based) technologies (e.g., chatbots, smart products, voice assistants, or autonomous cars) is gaining traction, the themes characterizing this emerging, interdisciplinary corpus of work remain indeterminate, exposing an important literature‐based gap. Addressing this gap, we conduct a systematic review of 89 studies using the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) approach to synthesize the AI‐based CE literature. Our review yields three major themes of AI‐based CE, including (i) Increasingly accurate service provision through AI‐based CE; (ii) Capacity of AI‐based CE to (co)create consumer‐perceived value, and (iii) AI‐based CE's reduced consumer effort in their task execution. We also develop a conceptual model that proposes the AI‐based CE antecedents of personal, technological, interactional, social, and situational factors, and the AI‐based CE consequences of consumer‐based, firm‐based, and human‐AI collaboration outcomes. We conclude by offering pertinent implications for theory development (e.g., by offering future research questions derived from the proposed themes of AI‐based CE) and practice (e.g., by reducing consumer‐perceived costs of their brand/firm interactions).
The Huntington's Disease Gene Discovery
Authors: Franklin Gustavo L. , Teive Hélio A.G. , Tensini Fernando Spina , Camargo Carlos Henrique Ferreira , de Lima Nayra de Souza Carvalho , de dos Santos Diego de Castro , Meira Alex T. , Tabrizi Sarah J. 
Published: January 2024

AbstractThe gene for Huntington's disease (HD) was discovered in 1993, after an international collaborative initiative that led researchers to remote regions of South America. It was the most remarkable milestone, since George Huntington's initial description. Through the phenomenological discussions led by Jean‐Martin Charcot and Willian Osler, and finally Americo Negrette's reports, which served as the inspiration for the Venezuela Project led by Nancy Wexler, the journey toward discovering the Huntington's disease (HD) gene was marked by substantial efforts. This monumental achievement involved the analysis of more than 18,000 blood samples and gathered dozens of researchers in an integrated effort, enabling the mapping of the gene on chromosome 4 in 1983 and leading, a decade later, to the precise localization and identification of the HTT gene. The discovery of the HD mutation represented a pivotal moment in the field of genetics and neurology, significantly enhancing our understanding of the disease and creating opportunities for future treatments. The progress made and the knowledge gained during this journey catalyzed the development of many innovative molecular techniques that have advanced research in other medical conditions. In this article, the authors celebrate three decades of this memorable event, revisiting the historical aspects, providing insights into the techniques developed, and delving into the paths that ultimately led to the discovery of the HD gene. © 2024 International Parkinson and Movement Disorder Society.
Near infrared ammonia sensing system based on on‐axis cavity‐enhanced absorption spectroscopy using board‐level mode‐locked circuit
Authors: Zhu Bingjie , Guan Gangyun , Wu Xuyang , Zheng Kaiyuan , Song Fang , Zheng Chuantao , Wang Yiding 
Published: January 2024

AbstractWe proposed a near‐infrared gas sensing system based on mode‐locked cavity‐enhanced absorption spectroscopy. A distributed feedback fiber laser (DFB‐FL) with a central wavelength of 1550 nm was employed as the light source, coupling with a Fabry–Perot (F‐P) cavity with an effective optical path length of 42.7 m served as the gas cell. By utilizing a homemade mode‐locked electric circuit and Pound–Drever–Hall (PDH) technique, the mode‐locking between the DFB‐FL and F‐P cavity was achieved with long‐term fluctuation of 3.2%. System performance was verified using ammonia as the analyte gas with a target line at 1550.17 nm. Allan variance analysis revealed that the minimum detection limit was 15.8 ppm with an averaging time of 216 s, corresponding to an absorption coefficient of 2.3 × 10−7 cm−1.