bluuebunny/crossref_metadata_2025_split huggingface dataset:
In gesprek met dr. Kees Huizinga
Authors: Merz Anna , Welp Pieter 
Published: December 2023

In gesprek met dr. Kees Huizinga – Proefschrift: The quest for effective regulatory enforcement – A goal-displacement perspective
In de serie ‘in gesprek met een pas gepromoveerde onderzoeker’ geven we aandacht aan promotieonderzoeken die voor toezichthouders relevant zijn. Hiervoor interviewen we als redactie van het Tijdschrift voor Toezicht (recent) gepromoveerde onderzoekers over hun onderzoek en de betekenis ervan voor het toezicht.In dit interview spraken Anna Merz en Pieter Welp, redacteuren van het Tijdschrift voor Toezicht, met Kees Huizinga die begin 2023 promoveerde aan de Erasmus Universiteit Rotterdam op zijn onderzoek naar doelverschuiving in toezicht. Kees werkt als coördinerend/specialistisch inspecteur bij de Inspectie Leefomgeving en Transport.
Hoe kun je risicogestuurd en efficiënt toezicht houden?
Authors: Boer Jeroen , Kroesemeijer Ralph 
Published: December 2023

Hoe kun je risicogestuurd en efficiënt toezicht houden? Een blik vanuit het prospectustoezicht van de Autoriteit Financiële Markten
Hoe kun je risicogestuurd en efficiënt toezicht houden? Hoe kun je (extra) focussen op de gebieden die de meeste aandacht verdienen en waar de risico’s voor de markt het grootst zijn? Risicogestuurd en efficiënt toezicht houden vraagt om het maken van keuzes en de opstelling van een duidelijke strategie. Dit artikel geeft een interessant kijkje in de keuken hoe het team van het Prospectustoezicht van de Autoriteit Financiële Markten dat doet, met invalshoeken, specifieke voorbeelden van situaties waar dit is toegepast en key takeaways die interessant zijn voor andere toezichthouders.
De AFM maakt werkwijze en software voor interventieselectie open source beschikbaar
Authors: van den Bergh Filip , Wiegman Leanne 
Published: December 2023

De AFM maakt werkwijze en software voor interventieselectie open source beschikbaar
De Autoriteit Financiële Markten heeft een werkwijze ontwikkeld voor de selectie van informele interventieinstrumenten. Deze werkwijze bestaat uit een gefaciliteerde sessie, software, een vragenlijst en een catalogus van instrumenten. Door al deze materialen vrij beschikbaar te maken en te delen met andere toezichthouders, willen wij een uitwisseling van methoden op gang brengen waarvan alle toezichthouders kunnen profiteren.
De bewijsmaatstaven in het handhavingsrecht
Authors: Sanders Thomas 
Published: December 2023

De bewijsmaatstaven in het handhavingsrecht – Wat houden ‘aannemelijk maken’ en ‘bewijzen’ eigenlijk in?
In het bestuursrechtelijke handhavingsrecht kennen wij formeel geen bewijsrecht, maar het is er in de praktijk wel. Zie uitgebreid: T.N. Sanders, Handboek toezicht, handhaving en invordering, Den Haag: Boom juridisch 2022, p. 525 e.v. Een belangrijk onderdeel van dit bewijsrecht zijn de twee verschillende bewijsmaatstaven. Ten eerste de bewijsmaatstaf bij bestraffende sancties. Deze maatstaf houdt in dat de overheid de overtreding moet bewijzen. Dat wil zeggen, het moet buiten redelijke twijfel komen vast te staan dat er een overtreding is. Dat betekent dat ‘[i]ngeval van twijfel’ aan de betrokkene ‘het voordeel van de twijfel [dient] te worden gegund’. ABRvS 20 maart 2019, ECLI:NL:RVS:2019:871. Ten tweede de bewijsmaatstaf bij herstellende sancties. Die maatstaf houdt in dat de overheid een feit ‘aannemelijk’ moet maken. ABRvS 8 april 2015, ECLI:NL:RVS:2015:1103. Wat deze tweede maatstaf inhoudt, is wat onduidelijk. In deze notenkraker sta ik stil bij een ogenschijnlijk weinig interessante uitspraak van de rechtbank Zeeland-West-Brabant Rb. Zeeland-West-Brabant 6 juni 2023, ECLI:NL:RBZWB:2023:3908. die wel treffend het verschil tussen de bewijsmaatstaven illustreert en een haakje geeft om eens langer stil te staan bij wat wij nu onder ‘aannemelijk maken’ moeten verstaan.
ASUHAN KEPERAWATAN DENGAN TINDAKAN PERAWATAN LUKA PADA PASIEN POST ORIF DI RUMAH SAKIT TK II PUTRI HIJAU MEDAN
Authors: Manalu Naudur Fitri Sari , Olivia Nina , Syafrinanda Virginia 
Published: December 2023

Abstract: Penatalaksanaan fraktur dengan tindakan Open Reduction Internal Fixation (ORIF) dapat mengakibatkan masalah atau komplikasi kulit seperti infeksi luka, dehisensi luka, viserasi luka, Surgical mump (parotis). Penerapan standar Operasional Prosedur perawatan Luka pada pasien post orif dapat mencegah komplikasi pasca bedah seperti infeksi dan mempercepat masa rawatan. Tujuan : Penelitian bertujuan untuk melakukan perawatan luka pasca pembedahan ORIF sesuai dengan standar Operasional Prosedur. Metodologi : Metodologi penelitian bersifat deskriptif dengan rangcangan studi kasus asuhan keperawatan dimulai dari pengkajian, Intervensi keperawatan, Implementasi keperawatan, dan Evaluasi keperawatan pada dua orang pasien pasca pembedahan ORIF hari ke tiga dengan diagnosa keperawatan kerusakan integritas kulit dan jaringan selama 3X24 jam. Intervensi keperawatan merujuk pada NIC & NOC Hasil : Hasil penelitian didapatkan dari kedua responden yang mengalami masalah kerusakan integritas kulit dan jaringan teratasi pada hari ketiga perawatan. Hal ini dibuktikan dengan tidak tampak tanda-tanda infeksi, kondisi luka tampak baik, nyeri berkurang, tidak tampak nekrosis, kondisi luka tampak lembab, luas luka mengalami penurunan dll Kesimpulan : Asuhan keperawatan dengan tindakan perawatan luka sesuai standar operasional pada pasien post Orif efektif dilakukan.
On the Enrolment of Citizens in the Civil Service in Modern Conditions
Authors: Moldabekov Yerkebulan , Saiymova Meiramkul , Nurgaliyeva Yenlik , Smagulova Assyl , Smagulov Ablay , Niyazbekova Shakizada 
Published: December 2023

Objective: The purpose of writing the article is to investigate the peculiarities of entry to work in state bodies, the conditions of admission to the civil service of the Republic of Kazakhstan, and the experiences of foreign countries in this area. Theoretical framework: The study considers labor legal relations in the public service, which are regulated by a number of laws and regulations. The most important of them include the following: The Law of the Republic of Kazakhstan «On Public Service» establishes the basic principles of organization and implementation of public service and more. Methodology: The Law of the Republic of Kazakhstan «On Public Service of the Republic of Kazakhstan» was adopted; it discloses additional norms and rules regulating labor relations in the bodies of public service. Findings: Examples of entry and work in the civil service of citizens of other countries, concepts, and characteristics are given. Research: Therefore, it is important that those entering the civil service have high competence, moral qualities, and an understanding of their responsibility to society. Originality/value: The importance of the research topic is that the quality of the civil service directly affects the development of the country and the level of well–being of its citizens.
THE INFLUENCE OF FINANCIAL LITERACY AND FINANCIAL INCLUSION TOWARDS MSME PERFORMANCE (A Case Study of Pananjung Market Shophouses' Owners)
Authors: Hasiholan Matthew Giovanni , Noveria Ana 
Published: December 2023

This study researches the effect of financial literacy and financial inclusion simultaneously on the performance of MSMEs that have been relocated to Pananjung Market in Pangandaran Regency. The type of research used in this research is descriptive and verification. The object studied in this study is the performance of UMKM shophouses in Pananjung Pangandaran Market. Researchers decided to use the number of MSME owners who were in the Pananjung Market Ruko as a sample of 40 people. Financial literacy was found to have a partial impact on the MSME performance of the MSME owners of Pananjung Market Shophouses based on the partial test (t test) conducted in this study. Secondly, the MSME performance of Pananjung Pangandaran Market Shophouse MSME owners is also partially influenced by financial inclusion. The results of this study's simultaneous test (F test) indicate that financial inclusion and financial literacy have a simultaneous impact on the MSME performance of the MSME owners of Pananjung Market Shophouses.
Impact of sex on antidepressant discontinuation in groups of similar cytochrome P450 phenotypes
Authors: Kosaski Dylan L. , Cole Kristin C. , Wright Jessica A. , El Melik Razan M. , Kung Simon , Nicholson Wayne T. , Leung Jonathan G. 
Published: December 2023

Abstract

Introduction
Although there are studies assessing reasons for antidepressant discontinuation, little is known about the impact of sex differences or cytochrome P450 phenotypes. Our objective is to assess discontinuation rates between males and females and whether CYP450 phenotype influences discontinuation.

Methods
This is a retrospective review of patients previously enrolled in the Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment database with major depressive disorder. Patients were evaluated for antidepressants trialed between January 1, 2009, and September 30, 2019. Survival analyses with competing risks were used to analyze discontinuation reasons. A Kaplan-Meier estimation method was used to assess the time to discontinuation and discontinuation rates. Analyses were also completed to assess discontinuation between men and women by phenotypic groups. All tests were two-sided, and p-values ≤ .05 were considered statistically significant.

Results
There were 620 antidepressant discontinuation events discovered from 1015 antidepressant trials included. Overall, the median time to discontinuation for males was 2.6 years and 1.9 years for females (hazard ratio [HR] 0.97 [95% confidence interval (CI): 0.80, 1.19], p = .77). The risk of discontinuation was not different between males and females in any of the phenotype groups, which was consistent in the multivariable analyses. Concomitant use of medications that inhibited or induced antidepressant metabolism increased the overall risk of discontinuation (HR 1.45, 95% CI [1.06, 1.99], p = .020) in a time-dependent analysis.

Discussion
We did not detect a significant difference in risk of antidepressant discontinuation rates between males and females even when accounting for cytochrome P450 phenotype. Future studies should account for whether medications that inhibit or induce antidepressant metabolism may be a crucial factor in antidepressant discontinuation.
Bimetallic Ru-Sn as Effective Catalysts for the Selective Hydrogenation of Biogenic Platform Chemicals at Room Temperature
Authors: Azzahra Atina Sabila , Dewi Heny Puspita , Mikrianto Edi , Sembiring Kiky Corneliasari , Sunnardianto Gagus Ketut , Nata Iryanti Fatyasari , Rodiansono Rodiansono , Jayanudin Jayanudin 
Published: December 2023

Supported bimetallic ruthenium-tin (denoted as Ru-Sn(x); x = molar ratio of Ru/Sn) catalysts were examined for room temperature (RT) hydrogenation of biogenic platform chemicals of levulinic acid (LA) to g-valerolactone (GVL). Six types of metal oxide support c.a. Nb2O5, TiO2, ZnO, ZrO2, g-Al2O3, active charcoal (AC), were employed as the support for Ru-Sn(x). Ru-Sn(3.0)/Nb2O5 (Ru/Sn = 3.0) that reduced at 500 oC demonstrated the highest yield of GVL (98%) at 30 oC, 30 bar H2 for 3 h. The increase in Sn loading amount (Ru/Sn = 1.5) resulted in decreasing of LA conversion (83%) under the same reaction conditions. Among the studied supported Ru-Sn catalysts, Nb2O5 and ZnO supports exhibited better catalytic performances than that other for RT hydrogenation of LA and various biogenic platform chemicals. The Ru-Sn(3.0)/Nb2O5 catalyst was characterized by means of various adsorption and spectroscopic techniques. The Ru-Sn(3.0)/Nb2O5 catalyst was found to be reusable without any significant loss of its activity. Copyright © 2023 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Trends in US Adult Smoking Prevalence, 2011 to 2022
Authors: Meza Rafael , Cao Pianpian , Jeon Jihyoun , Warner Kenneth E. , Levy David T. 
Published: December 2023

ImportancePresident Biden recently prioritized the fight against smoking as key to reducing cancer mortality.ObjectiveTo assess trends in smoking and illuminate the association between smoking and reducing deaths due to cancer.Design, Setting, and ParticipantsThis cross-sectional study used responses to National Health Interview Surveys from January 1, 2011, to December 31, 2022, to characterize trends in current smoking for key sociodemographic groups among US adults.ExposuresAge (18-24, 25-39, 40-64, and ≥65 years), family income (&amp;lt;200%, 200%-399%, and ≥400% of the federal poverty level [FPL]), educational level (less than high school, high school degree or General Educational Development, some college, and college degree or above), and race and ethnicity (Black, Hispanic, White, and other).Main Outcomes and MeasuresWeighted current smoking prevalence with 95% CIs by analysis group from 2011 to 2022. Average annual percentage change (AAPC) in smoking prevalence by analysis group is calculated using Joinpoint regression.ResultsData from 353 555 adults surveyed by the National Health Interview Surveys from 2011 to 2022 were included (12.6% Black, 15.0% Hispanic, 65.2% White, and 7.3% other race or ethnicity). Overall, smoking prevalence decreased among adults aged 18 to 24 years from 19.2% (95% CI, 17.5%-20.9%) in 2011 to 4.9% (95% CI, 3.7%-6.0%) in 2022 at an AAPC of −11.3% (95% CI, −13.2% to −9.4%), while it remained roughly constant among adults 65 years or older at 8.7% (95% CI, 7.9%-9.5%) in 2011 and 9.4% (95% CI, 8.7%-10.2%) in 2022 (AAPC, −0.1% [95% CI, −0.8% to 0.7%]). Among adults 65 years or older, smoking prevalence increased from 13.0% (95% CI, 11.2%-14.7%) in 2011 to 15.8% (95% CI, 14.1%-17.6%) for those with income less than 200% FPL (AAPC, 1.1% [95% CI, 0.1%-2.1%]) and remained roughly constant with no significant change for those of higher income. Similar age patterns are seen across educational level and racial and ethnic groups.Conclusions and RelevanceThis cross-sectional study found that smoking prevalence decreased from 2011 to 2022 in all age groups except adults 65 years or older, with faster decreases among younger than older adults. These findings suggest that the greatest gains in terms of reducing smoking-attributable morbidity and mortality could be achieved by focusing on individuals with low socioeconomic status, as this population has the highest smoking rates and the worst health prospects.
Perceptions of Data Set Experts on Important Characteristics of Health Data Sets Ready for Machine Learning
Authors: Ng Madelena Y. , Youssef Alaa , Miner Adam S. , Sarellano Daniela , Long Jin , Larson David B. , Hernandez-Boussard Tina , Langlotz Curtis P. 
Published: December 2023

ImportanceThe lack of data quality frameworks to guide the development of artificial intelligence (AI)-ready data sets limits their usefulness for machine learning (ML) research in health care and hinders the diagnostic excellence of developed clinical AI applications for patient care.ObjectiveTo discern what constitutes high-quality and useful data sets for health and biomedical ML research purposes according to subject matter experts.Design, Setting, and ParticipantsThis qualitative study interviewed data set experts, particularly those who are creators and ML researchers. Semistructured interviews were conducted in English and remotely through a secure video conferencing platform between August 23, 2022, and January 5, 2023. A total of 93 experts were invited to participate. Twenty experts were enrolled and interviewed. Using purposive sampling, experts were affiliated with a diverse representation of 16 health data sets/databases across organizational sectors. Content analysis was used to evaluate survey information and thematic analysis was used to analyze interview data.Main Outcomes and MeasuresData set experts’ perceptions on what makes data sets AI ready.ResultsParticipants included 20 data set experts (11 [55%] men; mean [SD] age, 42 [11] years), of whom all were health data set creators, and 18 of the 20 were also ML researchers. Themes (3 main and 11 subthemes) were identified and integrated into an AI-readiness framework to show their association within the health data ecosystem. Participants partially determined the AI readiness of data sets using priority appraisal elements of accuracy, completeness, consistency, and fitness. Ethical acquisition and societal impact emerged as appraisal considerations in that participant samples have not been described to date in prior data quality frameworks. Factors that drive creation of high-quality health data sets and mitigate risks associated with data reuse in ML research were also relevant to AI readiness. The state of data availability, data quality standards, documentation, team science, and incentivization were associated with elements of AI readiness and the overall perception of data set usefulness.Conclusions and RelevanceIn this qualitative study of data set experts, participants contributed to the development of a grounded framework for AI data set quality. Data set AI readiness required the concerted appraisal of many elements and the balancing of transparency and ethical reflection against pragmatic constraints. The movement toward more reliable, relevant, and ethical AI and ML applications for patient care will inevitably require strategic updates to data set creation practices.
Performance evaluation and mix proportion design of concrete using low‐quality recycled aggregate: Application for structural concrete in Vietnam
Authors: Nguyen Anh Duc , Dosho Yasuhiro 
Published: December 2023

AbstractThis study aims to promote the application of recycled aggregate concrete using low‐quality recycled aggregate, which can be easily obtained in Vietnam, mixed with normal aggregate. This is achieved by examining the performance evaluation of concrete using the relative quality index method and mix proportion design. If low‐quality recycled aggregate and normal aggregate can be combined in concrete in a suitable replacement ratio, as has been done in Japan, the proposed method can be used for structural concrete applications in Vietnam.
Epitaxial Growth of 1D Te/2D MoSe2 Mixed‐Dimensional Heterostructures for High‐Efficient Self‐Powered Photodetector
Authors: You Jiawen , Jin Zijing , Li Yuyin , Kang Ting , Zhang Kenan , Wang Wenliang , Xu Mengyang , Gao Zhaoli , Wang Jiannong , Kim Jang‐Kyo , Luo Zhengtang 
Published: December 2023

AbstractMixed‐dimensional heterostructures provide additional freedom to construct diverse functional electronic and optoelectronic devices, gaining significant interest. Herein, highly‐aligned pseudo‐1D tellurium is epitaxially grown on 2D monolayer transition metal dichalcogenides (TMDs), including MoSe2, MoS2, and WS2. A one‐pot chemical vapor deposition (CVD) technique eliminates the normally required transfer steps, thereby producing mixed‐dimensional heterostructures with an ultraclean interface. The controllable epitaxial growth of Te/TMD heterostructures are verified by Raman, scanning probe microscopy (SPM), and transmission electron microscopy (TEM) observation. The photoluminescence results indicate that the emission from TMDs is quenched in the heterostructure, confirming the efficient transfer of photogenerated carriers from TMDs to Te. Additionally, the mixed‐dimensional p‐n Te/MoSe2 heterojunction photodetector presents self‐driven behavior with high responsivity (328 mA W−1), external quantum efficiency (79%), and specific detectivity (8.2 ×  109 Jones). The modified facile synthesis strategy and proposed growth mechanism in this study shed light on synthesizing mixed‐dimensional heterojunctions. This opens avenues for fabricating functional devices with reduced sizes and high densities, further enabling miniaturization and integration opportunities.
Extracellular Vesicles in Infrapatellar Fat Pad from Osteoarthritis Patients Impair Cartilage Metabolism and Induce Senescence
Authors: Cao Yumei , Ruan Jianzhao , Kang Jingliang , Nie Xiaoyu , Lan Weiren , Ruan Guangfeng , Li Jia , Zhu Zhaohua , Han Weiyu , Tang Su'an , Ding Changhai 
Published: December 2023

AbstractInfrapatellar fat pad (IPFP) is closely associated with the development and progression of knee osteoarthritis (OA), but the underlying mechanism remains unclear. Here, it is find that IPFP from OA patients can secret small extracellular vesicles (sEVs) and deliver them into articular chondrocytes. Inhibition the release of endogenous osteoarthritic IPFP‐sEVs by GW4869 significantly alleviated IPFP‐sEVs‐induced cartilage destruction. Functional assays in vitro demonstrated that IPFP‐sEVs significantly promoted chondrocyte extracellular matrix (ECM) catabolism and induced cellular senescence. It is further demonstrated that IPFP‐sEVs induced ECM degradation in human and mice cartilage explants and aggravated the progression of experimental OA in mice. Mechanistically, highly enriched let‐7b‐5p and let‐7c‐5p in IPFP‐sEVs are essential to mediate detrimental effects by directly decreasing senescence negative regulator, lamin B receptor (LBR). Notably, intra‐articular injection of antagomirs inhibiting let‐7b‐5p and let‐7c‐5p in mice increased LBR expression, suppressed chondrocyte senescence and ameliorated the progression of experimental OA model. This study uncovers the function and mechanism of the IPFP‐sEVs in the progression of OA. Targeting IPFP‐sEVs cargoes of let‐7b‐5p and let‐7c‐5p can provide a potential strategy for OA therapy.
Wearable Magnetic Field Sensor with Low Detection Limit and Wide Operation Range for Electronic Skin Applications
Authors: Li Shengbin , Wu Yuanzhao , Asghar Waqas , Li Fali , Zhang Ye , He Zidong , Liu Jinyun , Wang Yuwei , Liao Meiyong , Shang Jie , Ren Long , Du Yi , Makarov Denys , Liu Yiwei , Li Run‐Wei 
Published: December 2023

AbstractFlexible electronic devices extended abilities of humans to perceive their environment conveniently and comfortably. Among them, flexible magnetic field sensors are crucial to detect changes in the external magnetic field. State‐of‐the‐art flexible magnetoelectronics do not exhibit low detection limit and large working range simultaneously, which limits their application potential. Herein, a flexible magnetic field sensor possessing a low detection limit of 22 nT and wide sensing range from 22 nT up to 400 mT is reported. With the detection range of seven orders of magnitude in magnetic field sensor constitutes at least one order of magnitude improvement over current flexible magnetic field sensor technologies. The sensor is designed as a cantilever beam structure accommodating a flexible permanent magnetic composite and an amorphous magnetic wire enabling sensitivity to low magnetic fields. To detect high fields, the anisotropy of the giant magnetoimpedance effect of amorphous magnetic wires to the magnetic field direction is explored. Benefiting from mechanical flexibility of sensor and its broad detection range, its application potential for smart wearables targeting geomagnetic navigation, touchless interactivity, rehabilitation appliances, and safety interfaces providing warnings of exposure to high magnetic fields are explored.