bluuebunny/crossref_metadata_2025_split huggingface dataset:
Icariin zeinmersomes display enhanced anti-proliferative and pro-apoptotic activities in colon cancer cells
Authors: Nasrullah Mohammed Z. , Ashour Osama M. , Alhakamy Nabil A. , Binmahfouz Lenah S. , Hareeri Rawan H. , Alsenani Faisal , Kutbi Hussam I. , Abdel-Naim Ashraf B. 
Published: February 2025

Abstract

Background
The present study aimed at investigating the effectiveness of zeinmersomes (ZMS)-based nano-formulation to enhance icariin (ICA) cytotoxicity in colon cancer cells. The prepared ICA-ZMS was characterized with respect to particle size, entrapment efficiency, and in vitro release.

Results
ICA-ZMS showed higher cytotoxicity in HCT-116 cells compared to HT-29 and Caco-2 cells with almost no cytotoxicity in normal HCoEpC colon cells. In this regard, ICA-ZMS exhibited potentiated cytotoxicity as compared to ICA-raw. In HCT-116 cells, ICA loaded on ZMS exhibited better cellular penetration compared to ICA-raw. The accumulation of HCT-116 in the S phase was identified using cell cycle analysis. Annexin V staining highlighted a potent pro-apoptotic activity of the prepared ICA-ZMS. This with confirmed by the observed up-regulated Bax and down-regulated Bcl-2 mRNA expression. Further, mRNA expression of p53, cytochrome C, and caspase-3 was significantly increased by exposing cells to ICA-ZMS. This was associated with a detectable decline in mitochondrial membrane potential. These data were confirmed by the ability of ICA-ZMS to significantly enhance the life span of Ehrlich ascites carcinoma-bearing mice.

Conclusion
This study suggests that the loading of ICA on ZMS nanoparticles enhances its cytotoxic and pro-apoptotic activities. This involves modulation of p53-dependent mitochondrial signaling.
Late-Onset Progressive Osseous Heteroplasia: 2 Unrelated Cases and Use of Positron Emission Tomography for Diagnosis
Authors: Pham Minh T , Mahan John D , Shah Summit H , Estes Steven I , Kaler Stephen G 
Published: February 2025

Abstract
Progressive osseous heteroplasia (POH) is a rare autosomal-dominant hereditary bone disorder caused by inactivating pathogenic variants in GNAS1. POH is characterized by progressive cutaneous ossification and heterotopic ossification in skeletal muscles and subdermal connective tissues. Understanding of the natural history and phenotypic heterogeneity of the illness is incomplete. We report 2 affected male subjects with a milder than usual clinical course, highlight their clinical presentations and molecular correlates, and propose sodium 18F-fluorine positron emission tomography (PET) scanning as a sensitive technique for POH diagnosis and management.
Combination Treatment with Spacer Placement Surgery Followed by Particle Radiotherapy for Lymph Node Metastasis from Uterine Cancer
Authors: Komatsu Shohei , Nagamata Satoshi , Terashima Kazuki , Demizu Yusuke , Suga Masaki , Kido Masahiro , Yanagimoto Hiroaki , Toyama Hirochika , Tokumaru Sunao , Okimoto Tomoaki , Terai Yoshito , Fukumoto Takumi 
Published: February 2025

Abstract

Background
The effectiveness of local treatment in lymph node metastasis from uterine cancer has been proven; the standard treatment is surgical intervention. Although radiotherapy, including particle radiotherapy (PRT), is an alternative local treatment, its application is often contraindicated owing to its proximity to the gastrointestinal tract. Combination treatment with spacer placement surgery followed by PRT is a potential solution to this problem. This study aimed to evaluate the outcomes of this combination treatment of lymph node metastases from uterine cancer.

Patients and Methods
Between December 2007 and March 2023, ten consecutive patients who underwent combination treatment comprising spacer placement surgery and subsequent PRT were assessed for treatment outcomes.

Results
The median survival time was 53.5 months; the 3- and 5-year overall survival rates were 76.2% and 38.1%, respectively. The 3- and 5-year local control rates in all patients were both 88.9%. The median volume irradiated at 95% of the treatment planning dose (V95%) of the gross tumor volume, clinical target volume, and planning target volume were 100.0%, 99.8%, and 92.2%, respectively. The median dose intensity covering 95% of the target volume (D95%) of the gross tumor volume/planned dose, clinical target volume/planned dose, and planning target volume/planned dose were 98.9%, 99.0%, and 87.2%, respectively.

Conclusions
Spacer placement surgery contributed to the optimized PRT dose distribution and might have contributed to favorable local control and survival rates. This innovative combination treatment might have a significant effect on the treatment of lymph node metastases from uterine cancers.
A Protocol to Establish Exercise Intensity Domains for Aerobic Exercise Training in Coronary Artery Disease
Authors: Faricier Robin , Keltz Randi R. , Hartley Tim , Mackay Nathan , Murias Juan M. , Huitema Ashlay A. , McKelvie Robert S. , Suskin Neville G. , Keir Daniel A. 
Published: February 2025

ABSTRACT

Introduction/Purpose

The oxygen uptake- (V̇O2) to-power output (PO) relationship from incremental exercise needs to be adjusted to accurately prescribe constant-intensity exercise training. We assessed accuracy of a “step-ramp-step” (SRS) protocol for prescribing constant-PO exercise within moderate- (below estimated lactate threshold, θLT), heavy- (between θLT and respiratory compensation point, RCP), and severe-intensity (above RCP) domains in fourteen patients with coronary artery disease (CAD).

Methods
The SRS protocol included in series: 6-min of cycling at 25-40 W, a ramp-incremental test until task failure (5-15 W·min−1), and, after recovery, 12-min of cycling at ~50-60% of peak ramp PO. On separate days, patients performed three domain-specific constant-PO exercises at 80%θLT (moderate-intensity, MOD), 70% of the difference between θLT and RCP (heavy-intensity, HVY), and 115%RCP (severe-intensity, SEV). Measured V̇O2 for: MOD and HVY were compared to those predicted using either SRS-corrected or uncorrected approaches; and, for SEV, were compared to peak ramp V̇O2.

Results
The POs for MOD, HVY, and SEV were 53 ± 27 W, 96 ± 50 W, and 116 ± 56 W, respectively, eliciting V̇O2 of 1012 ± 362 mL·min-1, 1541 ± 638 mL·min-1, and 1944 ± 744 mL·min-1. The SRS-corrected predictions did not differ from measured V̇O2 for MOD (-25 ± 61 mL·min-1; p = 0.201) or HVY (-40 ± 89 mL·min-1; p = 0.208), whereas uncorrected predictions underestimated V̇O2 by -128 ± 72 mL·min-1 (p = 0.002) and -199 ± 99 mL·min-1 (p = 0.001) in MOD and HVY, respectively. Peak V̇O2 from SEV did not differ from the ramp (1906 ± 766 mL·min-1; p = 0.759).

Conclusions
In CAD, the V̇O2-to-PO relationship from incremental exercise must be corrected to prescribe constant intensity training. The SRS protocol is an accurate approach to ensure prescriptive accuracy.
Fiqh al-Awlawiyat is the basis for education on halal food and beverage
Authors: Abdurrahman Usamah , Ardiani Yana Elita , Sa'adah Yaumi 
Published: February 2025

This study aims to elaborate on the conception of halal and its education in the contemporary context and explain how fiqh al-awlawiyat can be applied as a basis for halal education in food and beverage products. After explaining halal as Islamic ethics and morality at different levels, it is explained how fiqh al-awlawiyat is highly urgent in its operation. In the final section, by parsing several fiqh al-awlawiyat rules, four recommendations are given, namely: (1) qualitative indicators of halal achievements need to be proclaimed as a foundation for quantitative indicators that have so far been applied, (2) halal educators need to be equipped not only with practical knowledge about the administrative aspects of halal certification, but also more sophisticated scientific tools such as fiqh al-awlawiyat, fiqh al-waqi', fiqh al-maqasid, and so on, (3) in the education process, educators need to pay attention to the gradual process by directing business partners to take care of their compliance with halal values respectively starting from reciprocal ethics, tolerant ethics, and altruistic ethics based on their abilities, and (4) the education process should not end when halal certification has been obtained but continued so that it can reach a higher level.

Keywords: Education, Fiqh al-Awlawiyat, Food and Beverages, Halal, Islamic Ethics.
Opportunities and challenges for assisting MSMEs with halal products in Sungsang Village in Banyuasin Regency as a halal tourism destination
Authors: Falahudin Irham , Saputra Andi , Nurseha Tito , Rachmania Rachmania , Jayanti Sri Delasmi 
Published: February 2025

Indonesia is one of the countries with the largest adherents of Islam in the world. Indonesia is also a country that has great potential for tourism with halal products. One of the halal tourist destinations in South Sumatra is the fishing village in Sungsang Village, Banyuasin Regency. The Fisherman's Village in the Sungsang area has been used as a tourist destination by the Banyuasin Regency Regional Government, and it has been running well in recent years. The number of domestic and foreign tourists visiting the Sungsang area has reached hundreds or thousands. The research uses quantitative descriptions of MSMEs in the Banyuasin district. The results of the SWOT analysis can be developed into three models based on potential and uniqueness, namely: a tourist village pattern based on the uniqueness of local cultural resources, namely the decorative boat tradition, a tourist village pattern based on the uniqueness of natural resources as a fishing village tourist village and a tourist village pattern based on the uniqueness of industrial creative economic activities. craft crackers and shrimp pempek. Three models of halal tourism development in Sungsang Village, Banyuasin Regency, South Sumatra are supported by several IFAS and EFAS factors with a difference of 0.62 which is positive, namely: creative industry from MSMEs that already have halal certificates for their products, the availability of adequate places of worship in each village. and the existence of annual events in the form of traditional decorative boat competitions. The development of halal tourism in Sungsang Village also has challenges, including limited facilities and infrastructure, accommodation, and transportation access to tourist destinations. not enough.

Keywords: Challenges, Halal, MSMEs, Opportunities, Tourism.
A novel maternity clinical supervision service: overview and outcomes
Authors: Archibald Sarah-Jane , Shayle Amy , Hinde Camilla , Saunders Tessa , Garratt Claire , O'Curry Sara 
Published: February 2025

Background/Aims Stress can lead to low work satisfaction and increased burnout, sickness/absence and staff turnover. A midwifery clinical supervision service was developed by two senior clinical psychologists and piloted. It aimed to offer clinical supervision and staff support to specialist groups of midwives. Methods Questionnaires were completed by 47 staff who attended the pilot service, assessing their experiences and psychological outcome measures at the first and last sessions. Paired sample two‑tailed t‑tests were used to test for differences between baseline and follow‑up scores for wellbeing measures. Thematic analysis was used for qualitative data. Results Overall satisfaction was high, and attending multiple sessions significantly improved overall emotional wellbeing. Burnout was significantly lower, and there was a reduction in traumatic stress symptoms and improved rates of compassionate satisfaction. Conclusions Midwives and staff in maternity services value and benefit significantly from psychological support and specialist clinical supervision. Implications for practice Clinical supervision and staff support models should be provided in maternity services. This will directly impact the quality of care that staff provide.
Maternal perception of pregnancy loss: a qualitative systematic review
Authors: Freitas Conceição Moreira , Magalhães Bruno , Martinez-Galiano Juan Miguel 
Published: February 2025

Background/Aims Pregnancy loss is a complex and often stigmatised event with a significant impact on mothers. Understanding maternal perception is crucial for personalised care, but research on this is fragmented. This review synthesises qualitative studies on mothers' perceptions of pregnancy loss. Methods A systematic review with thematic synthesis was conducted across five databases (Medline, CINAHL, Psychology and Behavioural Sciences Collection, Scopus, Cochrane). Qualitative studies published between January 2012 and March 2024 were included. Results A total of 15 studies were selected. Five themes emerged: facilitators, inhibitors, context, professional support and impact. Conclusions Pregnancy loss deeply affects women's personal and professional lives, with perceptions shaped by support from family, healthcare professionals, and cultural or religious factors. Implications for practice Reforming hospital care and increasing emotional support for mothers and healthcare providers are critical. Further research should explore this topic to inform specific training and care strategies.
The Impact of COVID-19 on UK Medical Students’ Perceptions of Cardiothoracic Surgery—A Comparison of Nationwide Surveys in 2018 and 2022
Authors: Gnanalingham Sathyan , Gnanalingham Raman , Limbachia Devan 
Published: February 2025

Aims/Background The effects of the coronavirus disease 2019 (COVID-19) pandemic on surgical specialities have been devastating, with more than 1.5 million operations cancelled in 2020, leading to reduced training opportunities and morale. We investigated the impact of COVID-19 pandemic on UK medical students’ interest in pursuing a career in cardiothoracic surgery (CTS) and their perceptions of the field, including perceived challenges and opportunities. Methods This study is a comparative cross-sectional study design aiming to assess if there were changes in perceptions amongst UK medical students before and after COVID-19. We distributed the same online survey to all UK medical schools via social media outlets before COVID-19 in 2018 and after in 2022. The Chi-square test was used to analyze differences, with a significance level set a p < 0.05. Results Overall, career intentions of survey respondents towards CTS did not change between 2018 and 2022. However, students’ perceptions towards CTS became more negative (p = 0.033). In 2018, for instance, 37% of survey respondents had neutral or negative perceptions of CTS which increased to 59% in 2022. This result was statistically significant, indicating the negative impact of COVID-19 on UK medical students’ perceptions of CTS. Conclusion Overall, the effects of COVID-19 did not have a significant impact on medical student interest in a career in CTS. However, negative perceptions associated with a career in CTS persist. A new era of remote, hybrid career events and student modules in CTS could encourage greater interest.
Exploring the Impact of Training on the Mental Health Aspects of Intellectual and Developmental Disabilities for Direct Support Professionals
Authors: Grosso Elizabeth , Caoili Andrea , Nye-Lengerman Kelly 
Published: February 2025

Abstract
The Mental Health Aspects of IDD (IDD-MH) Course for Direct Support Professionals (DSPs) is a six-session, live, virtual course offered by the National Center for START Services, a program of the Institute on Disability at the University of New Hampshire. It is co-facilitated by clinicians and people with lived experience of intellectual and developmental disabilities with mental health conditions (IDD-MH). Evaluation results (N = 193) of three training cohorts (2021-2022) are analyzed to examine quantitative and qualitative changes in knowledge, perspective, and confidence regarding provision of positive, strengths-based support to people with IDD-MH. The study concludes with the identification of future topics for DSP training.
Adaptation and validation of a Rwanda-focused version of the Alcohol Use Disorder Identification Test (AUDIT)
Authors: Rosenberg Noah , Buono Mia , Ndebwanimana Vincent , Niyonzima Joseph , Merchant Roland C. , Beeman Aly , Staton Catherine A. , Vissoci Joao Ricardo Nickenig 
Published: February 2025

In Rwanda, alcohol use disorder (AUD) is estimated to affect 7% of the population. The Alcohol Use Disorder Identification Test (AUDIT) is an excellent screening instrument for AUD, but a Rwanda-focused version previously was unavailable. Our objective was to develop a Rwanda- focused AUDIT and evaluate its psychometric properties.
The English AUDIT was adapted to the Rwandan language through translation and back- translation by a panel of native English and Kinyarwanda speakers. Random sampling was used to recruit participants from the emergency department, outpatient clinics, and inpatient wards at a tertiary care center in Rwanda, excluding those < 18 years old, declining to participate, unable to provide consent, or when participation would interfere with care. Participants completed the Rwanda-focused AUDIT using an audio computer-assisted self-interviewing format. Internal structure was assessed using one-, two- and three-dimensional models of fit and confirmatory factor analysis (CFA), assessed by Chi-square (χ2), Root Mean Square Error of Approximation (RMSEA), Tucker-Lewis index (TLI) and comparative fit index (CFI).
Of 775 patients assessed for enrollment, 7% were unable to provide consent, 12% declined to participate, 2% could not participate because it would disrupt their medical care, and 1.3% dropped out, leaving 614 included for analysis. Of the 614, the majority were male (61%), married (53%) and had only primary education (65%). Their ages were: 33% 18-30, 43% 31-50, and 25% > 50 years-old. Factor loading for the AUDIT CFA model was between 0.62 and 0.96 for all items. Model fit indices included χ2 of < 0.001, RMSA of 0.061 (0.049 - 0.073), TLI of 0.994, and CFI of 0.995. Reliability statistics included Cronbach’s alpha at 0.91 (0.90 – 0.92), Omega 6 at 0.948 and composite reliability at 0.977.
The Rwanda-focused AUDIT showed excellent performance for measures of internal structure with high factor loading on CFA and model fit indices meeting traditional parameters of RMSEA < 0.08, TLI > 0.90, and CFI > 0.95. In this context, χ2 should ideally be > 0.05, however a relatively large sample, such as ours, tends to depress the number. All reliability statistics were above 0.90, indicating strong internal consistency. These findings support the reliability of this screening instrument. Further research should focus on the development of brief interventions for those who screen positive.
The Neumann function and the L

p
Neumann problem in chord-arc domains
Authors: Hofmann Steve , Sparrius Derek 
Published: February 2025

Abstract
We construct the Neumann function in a 1-sided chord-arc domain (i.e., a uniform domain with an Ahlfors regular boundary), and establish size and Hölder continuity estimates up to the boundary. We then obtain a Kenig-Pipher type theorem, in which L

p
solvability of the Neumann problem is shown to yield solvability in L

q
for 1 < q < p, and in the Hardy space H
1, in 2-sided chord-arc domains, under suitable background hypotheses.
Experimental study on automation and data-driven modeling in the punching-collar forming process
Authors: Korenek Jakub , Riemer Matthias , Kräusel Verena , Langhammer Dominic , Koschmider Agnes 
Published: February 2025

Abstract
The article presents the findings of experimental investigations into the two-stage punching-collar forming process. The conducted investigations provide an extensive knowledge basis for the design of the fully automated progressive tool and a detailed analysis. The knowledge gained will allow for design adjustments of the planned progressive forming tool and the schematic representation of the automated system. In addition, the initial correlations can be identified in the data analysis, which will enable the derivation of a data-driven process model. The findings of this research will enable precise predictions about process reliability and product quality, thereby serving the derivation of the optimisation approaches for the punching-collar forming process.
Training for ethical linguistics: a model for building “responsible conduct of research” into department culture
Authors: Dobrin Lise M. 
Published: February 2025

Abstract
What aspects of a linguist’s work should be covered in training for ethical linguistics? Are they specific to the study of language? Specific to the treatment of research subjects? Specific to the practice of research? Having a clear answer is a necessary first step in planning an effective ethics education program. Related questions are which institution(s) should take responsibility for it and what settings will be most conducive to ethical learning. Should training take place in the classroom, the research lab, the department, professional society meetings? Inspired by the “Responsible Conduct of Research” U.S. regulatory framework, this article presents an approach to department-level ethics education that moves beyond individual compliance and instead has as its goal the cultivation of a next generation of linguists who are able to identify and respond to the ethical issues that arise in all aspects of the work that they do.
Generalized Sasaki mappings in d0-Algebras
Authors: Avallone Anna , Vitolo Paolo 
Published: February 2025

Abstract
We define the notion of a generalized Sasaki mapping on a d0-algebra. We also introduce d0-algebras with the Sasaki property and, for such d0-algebras, we construct the generalized Sasaki projection, which turns out to be a generalized Sasaki mapping.
Integrating barrier chemicals into coating systems for optimized white top testliner performance
Authors: Acar Nuray , Atik Celil , Bağbakar Orhan Duygu 
Published: February 2025

Abstract
This investigation examined the development of a coating blend suitable for white top testliner paper to enhance its barrier properties and printability. The research focused on analyzing and elucidating the rheological and barrier properties crucial for the effective application of coating color. A double-coat application process was employed, with the pre-coating layer filling the rough surface profile and the top-coating layer improving the smoothness. Clay and calcium carbonate were used as pigments and latex as binder. Dispersant and thickener were also added. A barrier chemical was also incorporated in select formulations. The results indicated that the coating significantly modified the optical and barrier properties of the paper. The brightness, whiteness, and grease resistance increased, whereas the air permeability decreased. Barrier chemicals were particularly efficacious in reducing wettability and improving grease resistance. In conclusion, this study demonstrates that a well-designed coating strategy can enhance the functionality of recycled paper, rendering it a more viable option for packaging application.