bluuebunny/crossref_metadata_2025_split huggingface dataset:
On “Reflections on the concept of optimality of single decision point treatment regimes”
Authors: Moodie Erica E. M. , Talbot Denis 
Published: October 2023

AbstractThis is a discussion of “Reflections on the concept of optimality of single decision point treatment regimes” by Trung Dung Tran, Ariel Alonso Abad, Geert Verbeke, Geert Molenberghs, and Iven Van Mechelen. The authors propose a thoughtful consideration of optimization targets and the implications of such targets for the resulting optimal treatment rule. However, we contest the assertation that targets of optimization have been overlooked and suggest additional considerations that researchers must contemplate as part of a complete framework for learning about optimal treatment regimes.
Prophylactic and abundant intake of α‐lipoic acid causes hepatic steatosis and should be reconsidered in usage as an anti‐aging drug
Authors: Kuhla Angela , Derbenev Margarita , Shih Hao Yu , Vollmar Brigitte 
Published: October 2023

AbstractThe majority of research has suggested that α‐lipoic acid (ALA) is a potential therapeutic agent for chronic diseases associated with oxidative stress, including atherosclerosis, diabetes, and neurodegeneration. Therefore, a nutritional supplementation with ALA is recommended although the effects of a short‐ and long‐term intake of ALA on central organs in healthy individuals are not studied in detail yet. Therefore, liver tissue of 4 and 74 weeks ALA‐treated healthy C57BL6/J mice with respect to lipid metabolism was analyzed. In doing so, it was shown that short‐term and long‐term ALA treatment caused a marked increase of β‐oxidation, as indicated by a significant rise of mRNA expression of fgf21, pparα, and its target genes, for example, acox1, cpt1α, and cpt2, as well as of Fgf21 plasma concentration. Glycolytic activity, as assessed by pklr1 mRNA expression and pyruvate kinase activity, was also found increased. In addition, it was shown that both short‐ and long‐term ALA treatment increased cholesterol content, induced systemic triglyceridemia, and enhanced rxrα and lxrα mRNA expression. Despite the fact that short‐term ALA intake reduced lipogenesis, as given by significant declines of fas and srebp1c mRNA expression, and that a long‐term ALA intake induced a significant rise of these lipogenic genes, both treatment regimen caused fat accumulation. This, however, was more pronounced upon long‐term ALA intake, leading to hepatic steatosis and liver injury, as indicated by increased inflammation and disruption of the general hepatic architecture. In summary, the prophylactic and abundant use of ALA under healthy conditions should be considered with caution. © 2016 BioFactors, 42(2):179–189, 2016
Using Zombies to Teach Collaborative Scholarship and Born‐Digital Publishing
Authors: Thomas Jamie A. 
Published: October 2023

EDITOR'S SUMMARYZombies have been sweeping across all types of media for many years, and their popularity continues to rise with TV shows like The Walking Dead and movies like Warm Bodies. The popularity of entertainment about the undead presents an interesting opportunity to draw parallels between the fiction of zombies and the reality of human politics, societies and issues. In an effort to connect this discourse with born‐digital publishing, [ZOMBIES REIMAGINED] was created. The effort behind [ZOMBIES REIMAGINED] was undertaken by faculty, students and librarians at Swarthmore College, and it was launched in May 2016 as a public website with individual exhibits in the form of web pages. The web pages were authored by students in the author's seminar and turned into an online experience with the help of Swarthmore librarians. Due to the success of the project, a large update to the site was launched in May 2017 with all new student authors and topics discussed.
Impact of Metabolic Stress on BeWo Syncytiotrophoblast Function**
Authors: Rogers Lisa M. , Huggins Marissa , Doster Ryan S. , Omage Joel I. , Gaddy Jennifer A. , Eastman Alison , Aronoff David M. 
Published: October 2023

AbstractDuring placental formation, cytotrophoblasts (CTBs) fuse into multinucleate, microvilli‐coated syncytiotrophoblasts (STBs), which contact maternal blood, mediating nutrient, metabolite, and gas exchange between mother and fetus, and providing a barrier against fetal infection. Trophoblasts remodel the surrounding extracellular matrix through the secretion of matrix metalloproteinases (MMPs). Maternal obesity and diabetes mellitus can negatively impact fetal development and may impair trophoblast function. We sought to model the impact of metabolic stress on STB function by examining MMP and hormone secretion. The BeWo CTB cell line was syncytialized to STB‐like cells with forskolin. Cell morphology was examined by electron microscopy and immunofluorescence; phenotype was further assessed by ELISA and RT‐qPCR. STBs were exposed to a metabolic stress cocktail (MetaC: 30 mM glucose, 10 nM insulin, and 0.1 mM palmitic acid). BeWo syncytialization was demonstrated by increased secretion of HCGβ and progesterone, elevated syncytin gene expression (ERVW‐1 and ERVFRD‐1), loss of tight junctions, and increased surface microvilli. MetaC strongly suppressed syncytin gene expression (ERVW‐1 and ERVFRD‐1), suppressed HCGβ and progesterone secretion, and altered both MMP‐9 and MMP‐2 production. Metabolic stress modeling diabetes and obesity altered BeWo STB hormone and MMP production in vitro.
Interfacing Whole Cell Biocatalysis with a Biocompatible Pictet‐Spengler Reaction for One‐Pot Syntheses of Tetrahydroisoquinolines and Tryptolines**
Authors: Andersen Campbell M. , Knudson Luke D. , Domaille Dylan W. 
Published: October 2023

AbstractBiocatalytic processes are highly selective and specific. However, their utility is limited by the comparatively narrow scope of enzyme‐catalysed transformations. To expand product scope, we are developing biocompatible processes that combine biocatalytic reactions with chemo‐catalysis in single‐flask processes. Here, we show that a chemocatalysed Pictet‐Spengler annulation can be interfaced with biocatalysed alcohol oxidation. This two‐step, one‐pot cascade reaction converts tyramine and aliphatic alcohols to tetrahydroisoquinoline alkaloids in aqueous buffer at mild pH. Tryptamine derivatives are also efficiently converted to tryptolines. Optimization of stoichiometry, pH, reaction time, and whole‐cell catalyst deliver the tetrahydroisouinolines and tryptolines in >90 % and >40 % isolated yield, respectively, with excellent regioselectivity.
Oxide‐derived Silver Nanowires for CO2 Electrocatalytic Reduction to CO
Authors: Mattarozzi Francesco , van der Willige Nolan , Gulino Valerio , Keijzer Claudia , van de Poll Rim C. J. , Hensen Emiel J. M. , Ngene Peter , de Jongh Petra E. 
Published: October 2023

AbstractSilver electrocatalysts offer the possibility to produce CO by converting CO2, enabling the use of a greenhouse gas as chemical building block. Compared to nanoparticles, silver nanowires show an enhanced selectivity towards CO. Recent publications proved that oxide‐derived electrocatalysts can exhibit better catalytic performance than the pristine metal phase, but oxide‐derived silver nanowires have not been investigated. In this work, we report for the first time the electrocatalytic properties of silver nanowires, synthesized via the polyol method, and pretreated by electrochemical oxidation in basic electrolyte. By increasing the oxidation potential, both the percentage of AgxO and the surface roughness of the catalyst were progressively increased. The most oxidized sample showed a remarkably improved CO selectivity (−294.2 mA m−2Ag), producing a 3.3‐fold larger CO partial current density than the pristine sample (−89.4 mA m−2Ag), normalized by electrochemically active silver surface area. This work demonstrates the beneficial effect of the controlled oxidation treatment even on highly selective nanostructures such as silver nanowires.
First Use of Thiosquaramides as Polymerization Catalysts: Controlled ROP of Lactide Implicating Key Secondary Interactions for Optimal Performance
Authors: Printz Gaël , Ryzhakov Dmytro , Gourlaouen Christophe , Jacques Béatrice , Messaoudi Samir , Dumas Françoise , Le Bideau Franck , Dagorne Samuel 
Published: October 2023

AbstractWe herein report the first use of thiosquaramides as polymerization catalysts, which are shown to be effective for the controlled ROP of lactide in the presence of an alcohol source and NEt3. Comparison of their catalytic performances with the less acidic squaramides are also discussed. The observed catalytic activity of variously N‐substituted thiosquaramides suggest that a balanced NH Brønsted acidity is required for optimal performance. Most interestingly and rather unexpectedly, DFT‐supported calculations on thiosquaramide‐mediated lactide ROP catalysis suggest that secondary interactions between the thiosquaramide N‐substituents and the incoming lactide (presently of type C‐H⋅⋅⋅π‐arene) are crucial for catalytic activity. Though this type of interactions is quite common in organo‐catalysis, it has rarely been evidenced to play a key role in the area of organo‐catalyzed polymerizations. Such catalyst substituents/substrate interactions may well play a significant role in the catalytic performances of various other systems.
Hölder regularity of the Boltzmann equation past an obstacle
Authors: Kim Chanwoo , Lee Donghyun 
Published: October 2023

AbstractRegularity and singularity of the solutions according to the shape of domains is a challenging research theme in the Boltzmann theory. In this paper, we prove an Hölder regularity in for the Boltzmann equation of the hard‐sphere molecule, which undergoes the elastic reflection in the intermolecular collision and the contact with the boundary of a convex obstacle. In particular, this Hölder regularity result is a stark contrast to the case of other physical boundary conditions (such as the diffuse reflection boundary condition and in‐flow boundary condition), for which the solutions of the Boltzmann equation develop discontinuity in a codimension 1 subset (Kim [Comm. Math. Phys. 308 (2011)]), and therefore the best possible regularity is BV, which has been proved by Guo et al. [Arch. Rational Mech. Anal. 220 (2016)].
A weighted average mixed feedback control method based on LCL‐type grid‐connected inverter
Authors: Li Yulong , Yang Ming , Yang Zhuo , Zhu Jun 
Published: October 2023

SummaryThe weighted average current (WAC) control method has gained recognition for its order reduction characteristics and broad control bandwidth. However, the interaction of digital control delay and grid impedance introduces an inverse resonance peak in the system loop gain, challenging the order reduction properties of conventional WAC control and system passivity across a wide frequency range. Conventional approaches, such as lead compensator‐based delay compensation or weighting coefficient redesign, improve system stability to some extent but fail to retain order reduction characteristics. To address these limitations, this article proposes a new control method known as weighted average mixed feedback, incorporating distinct voltage feedforward paths. By introducing a voltage feedback path, the proposed method reconfigures the system's zero positions, enabling the pole‐zero cancelation in the open‐loop characteristics independent of grid impedance. Additionally, this supplementary path offers impedance reshaping capabilities, enhancing system passivity and adaptability to weak grids. The effectiveness of the proposed control method is verified through simulations and experiments.
Review on single‐phase high‐frequency resonant inverters for current sharing in multiple inverter system
Authors: Pengyu Zhang , Junfeng Liu , Mingze Ma , Zijie Fang , Hao Zhou , Jun Zeng 
Published: October 2023

SummarySingle‐phase high‐frequency resonant inverters (SPHFRIs) with high power density, fast dynamic response, and high energy conversion efficiency have been widely studied and used in academia and industry. With the development of the modularization concept, the operation of multiple inverter modules is desirable because it can remove the limitations of cost, heat dissipation, and component volume in single inverter operation. However, a critical challenge in multiple inverter systems is that the both the phase and magnitude of the output voltage of each inverter module must be controllable to eliminate circulating currents between inverter modules. Great efforts have been made to solve this problem from three aspects: topology, modulation, and control strategy. In this paper, modulation strategies and topologies of different inverters are presented and reviewed to provide guidance to researchers working in this field. Firstly, multiple inverter system based on the SPHFRI is described and its advantages and disadvantages are analyzed. An important issue in the study of multiple inverter systems is presented, that is, the suppression of circulating current. Secondly, the circulating currents in a multiple inverter system are analyzed and derived from two aspects: (1) magnitude and phase angle and (2) active and reactive currents. Thirdly, the inverters used in the multiple inverter system are introduced, and their operating principles, advantages, and disadvantages are reviewed. A key comparison of several inverters is presented for the benefit of the readers. Fourth, through PI closed‐loop simulation, the performance of different multiple inverter systems for suppressing the circulating current is compared in two situations: (1) with magnitude discrepancy only and (2) with both magnitude and phase discrepancy. Finally, the advantages and disadvantages of each inverter are summarized, and the state of the art and future trends are presented.
Manufacturing of Electric Double‐Layer Capacitors Using Carbon Nanocoils and Evaluation of their Specific Capacitances at a High Scan Rate
Authors: IZUMI HARUTAKA , SUDA YOSHIYUKI , OKABE YUTA , TAKIKAWA HIROFUMI , TANOUE HIDETO , UE HITOSHI , SHIMIZU KAZUKI 
Published: October 2023

SUMMARYElectric double‐layer capacitors (EDLCs) have problems that the specific capacitance decreases by increasing the scan rate. In this study, activated carbon (AC) and various carbon nanomaterials are compared by their specific capacitances. Carbon nanomaterials used in this study were arc‐black (AcB) which was prepared by an arc discharge and carbon nanocoil (CNC) which was prepared by a chemical vapor deposition. CNC and AcB showed the lower charge transfer resistance than AC in the measurement of electrochemical impedance spectroscopy (EIS). This is a reason that the EDLCs using CNC and AcB kept their specific capacitance almost the same even at a high scan rate.
Photoluminescence and Radiation Luminescence in a Hybrid Cuprous (I) Halide: (4,4‐Difluoro‐bipiperidinium)3Cu2I5
Authors: Cheng Yan , Zhu Bing‐Jun , Zhang Ya‐Di , Yao Hai‐Quan , Feng Yan , Shi Chao , Miao Le‐Ping , Ye Heng‐Yun 
Published: October 2023

AbstractCopper (I) based halide scintillators have received high attention due to their high light yield. At the same time, researchers are increasingly interested in exploring organic‐inorganic hybrid copper(I) based halides, due to the diversity and tunability of structures. Here, we describe high‐efficiency photoluminescence and X‐ray excited luminescence in (DFPD)3Cu2I5 (1) (DFPD=4,4‐difluoro‐bipiperidinium). 1 is comprised of a unique [Cu2I5]3− cluster, which have typical structure allowing high‐transition‐probability self‐trapped exciton emission (one Cu+ ion adopts the tetrahedral coordination geometry, the other trigonal planar coordination geometry, the Cu−Cu distance (2.574 Å) is short). Accordingly, 1 shows efficient yellow‐green photoluminescence with the maximum at 527 nm, a full‐width at half‐maximum of 99.2 nm, a large Stokes shift of 214 nm (1.6 eV) and a quantum yield of 77.15 %. Polycrystalline 1 can also convert high‐energy X‐ray photons into UV‐visible pulsed fluorescence with the light yield of 5000 photons/MeV. This finding plays a valuable role in the development of organic‐inorganic hybrid copper(I) based scintillators.
The adaptation of the desirability of outcome ranking for interventional clinical trials in epilepsy: A novel consumer‐led outcome measure
Authors: Vivash Lucy , Johns Hannah , O'Brien Terence J. , Churilov Leonid 
Published: October 2023

AbstractInterventional clinical trials in epilepsy are typically designed and powered to detect a change in seizure frequency as the primary endpoint, with little consideration given to other benefits or harms of the therapy, or impacts on common epilepsy comorbidities. Desirability of outcome ranking (DOOR) is a novel methodology for evaluating benefits and harms associated with introduction of a new treatment. Multiple outcomes are combined and the resulting combinations are ranked according to their desirability. Herein we describe the adaptation of DOOR for use in therapy trials in epilepsy. Consumers with epilepsy were presented with a selection of measures typically included in epilepsy trials and asked to rank their importance in terms of a desirable outcome and to identify interactions between different seizure control levels and other measures. Seizure control, adverse events, and psychiatric comorbidities were identified as most important, and combinations of these outcomes were ranked to form epilepsy‐DOOR. A separate consumer discussion group verified the appropriateness and accuracy of the ranking. The resultant epilepsy‐DOOR includes 60 possible outcomes, representing high granularity for the assessment of future interventions. It demonstrates the importance of consumer involvement in trial design and presents an alternative to seizure frequency for evaluating new treatments for epilepsy.
Design and validation of a scale of core components of community interventions in mental health
Authors: Agudelo‐Hernández Felipe , Rojas‐Andrade Rodrigo 
Published: October 2023

AbstractAimsTo develop and validate an instrument to identify the core components of community strategies for mental health, especially mutual aid groups: The Mutual Aid Scale .Methods135 community strategies leaders participated in the study. The core components are active agency, coping strategies, recognition, and management of emotions, problem‐solving strategies, supportive interaction, trust, self‐identity construction, and strengthening of social networks. With these components a scale was designed. Content validity was carried out in addition to an exploratory factor analysis.ResultsTwo dimensions resulted, strengthening of agency capacity and Coping strategies, and the internal consistency of both factors was acceptable, with a Cronbach's alpha of 0.722 and 0.727, respectively. The Kaiser‐Meyer‐Olkin (KMO) statistic was used with a score of 0.831 and the Barlett Sphericity Test, with a significant value of 265.175.ConclusionThis scale identifies the components of community interventions for mental health and can contribute to a better implementation of these strategies. It also articulates autonomous community processes with strategies developed in health services.
Approach to managing obesity in parrots
Authors: Chitty John 
Published: October 2023

Background: Obesity is an important issue in birds. As in other species it results from an imbalance between dietary calorie intake and calorie usage. Therefore, its causes and management require knowledge of the normal diet and biological activities of these species. Although causes and effects of obesity are largely similar across species boundaries, there is sufficient diversity between bird groups and species that this article will concentrate on just one group – the Psittacidae (parrots and cockatoos).Aim of the article: This article discusses the issue of obesity and its causes, as well as the recognition of the problem and the consequences of obesity in parrots. It also covers the management of obesity and its prevention.
Hyperchloremic metabolic acidosis after plasma exchange in a patient with renal transplant rejection: A case report
Authors: Simon S.S.A. , van Sandwijk M.S. , Olde Engberink R.H.G. 
Published: October 2023

AbstractTherapeutic plasma exchange (TPE) is an effective treatment for several renal disorders, including renal transplant rejection. However, repeated plasma exchanges can result in various metabolic disturbances and complications. We present a 61‐year old male with a medical history of type 2 diabetes, hypertension, successfully treated multiple myeloma, and a post‐mortem kidney transplantation 7 months prior to presentation. The patient was hospitalized with an antibody‐mediated transplant rejection for which treatment with methylprednisolone, TPE with a 40 g/L albumin solution as a replacement fluid, and intravenous immunoglobulins was initiated. After four TPE treatments, the patient developed gastrointestinal complaints and muscle weakness. Despite daily oral bicarbonate supplementation, laboratory tests revealed a hyperchloremic metabolic acidosis: bicarbonate 11.7 mmol/L, chloride 111 mmol/L, and sodium 138 mmol/L. Metabolic acidosis due to citrate accumulation was ruled out with a normal total‐to‐ionized calcium ratio. After treatment with intravenous bicarbonate supplementation, the symptoms disappeared. Analysis of the albumin solution showed a chloride concentration of 132 mmol/L. This is the first case that describes severe metabolic acidosis after multiple sessions of TPE with an albumin solution in a patient with impaired renal function. The hyperchloremic metabolic acidosis is the result of administration of large volumes of an albumin solution with high chloride concentrations. Special attention should be paid to the acid–base balance during TPE in patients with impaired renal function. Future research should investigate the incidence of hyperchloremic metabolic acidosis during TPE in patients with impaired renal function.
Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review
Authors: Amirizad Kazem , Ghazanfari Mona , Javidnia Javad , Abastabar Mahdi , Haghi Ashtiani Mohammad Taghi , Sotoudeh Anvari Maryam , Fathi Maryam , Espahbodi Amirreza , Badali Hamid , Hedayati Mohammad Taghi , Haghani Iman , Seyedmousavi Seyedmojtaba 
Published: October 2023

AbstractBackgroundViral pneumonia such as COVID‐19‐associated aspergillosis could increase susceptibility to fungal super‐infections in critically ill patients.MethodsHere we report a pediatric case of Aspergillus quadrilineatus cerebral infection in a recently diagnosed COVID‐19‐positive patient underlying acute lymphocytic leukemia. Morphological, molecular methods, and sequencing were used to identify this emerging species.ResultsHistopathological examination showed a granulomatous necrotic area containing dichotomously branching septate hyphae indicating a presumptive Aspergillus structure. The species‐level identity of isolate growing on brain biopsy culture was confirmed by PCR sequencing of the β‐tubulin gene as A. quadrilineatus. Using the CLSI M38‐A3 broth microdilution methodology, the in vitro antifungal susceptibility testing demonstrated 0.032 μg/mL MIC for posaconazole, caspofungin, and anidulafungin and 8 μg/mL against amphotericin B. A combination of intravenous liposomal amphotericin B and caspofungin therapy for 8 days did not improve the patient's condition. The patient gradually continued to deteriorate and expired.ConclusionsThis is the first COVID‐19‐associated cerebral aspergillosis due to A. quadrilineatus in a pediatric patient with acute lymphocytic leukemia. However, comprehensive screening studies are highly recommended to evaluate its frequency and antifungal susceptibility profiles. Before being recommended as first‐line therapy in high‐risk patients, more antifungal susceptibility data are needed.