bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soluble guanylate cyclase stimulators for heart failure: a network meta-analysis and subgroup analyses of reduced and preserved ejection fraction
Authors: Abuelazm Mohamed T. , Attia Abdelrahman , Abdelnabi Mohamed , Jafar Uzair , Almaadawy Omar , Elzeftawy Mohamed A. , Mahmoud Abdelrahman , Albakri Khaled , Abdelazeem Basel 
Published: January 2024

Abstract
Background
Soluble guanylate cyclase (sGC) stimulators have been investigated for heart failure (HF) in several randomized controlled trials (RCTs). However, its place in the management guidelines of either HFrEF or HfpEF is still inconclusive.

Methods
We conducted a network meta-analysis synthesizing RCTs investigating sGC for HF management, which were retrieved by systematically searching five databases until January 24th, 2023. Dichotomous outcomes were pooled using risk ratio (RR) along with confidence interval (CI).

Results
Eight RCTs with a total of 7307 patients were included. Vericiguat 10 mg significantly reduced the composite cardiovascular (CVS) mortality and HF hospitalization in HF (RR: 0.88, 95% CI [0.79; 0.98]) and in HFrEF (RR: 0.87, 95% CI [0.78; 0.97]); however, it was not effective in HFpEF (RR: 0.69, 95% CI [0.15; 3.05]). Also, vericiguat 10 mg showed no difference compared to placebo regarding the incidence of all-cause mortality (RR: 0.96, 95% CI [0.84; 1.10]), any adverse events (AEs) (RR: 0.94, 95% CI [0.83; 1.07]), any serious AEs (RR: 0.91, 95% CI [0.81; 1.01]), and any AEs leading to drug discontinuation (RR: 1.14, 95% CI [0.92; 1.40]).

Conclusion
Vericiguat 10 mg was effective in reducing the composite CVS mortality and HF hospitalization, with an acceptable safety profile. This was only observed in HFrEF patients, but not in HFpEF patients. However, our data regarding other agents (riociguat and praliciguat) and HFpEF can be underpowered, warranting further RCTs to clarify vericiguat 10 mg place in HFrEF management guidelines and to investigate sGC stimulators for HFpEF in large-scale trials.
Characterization of resonant coupled inductor in a wireless power transfer system
Authors: Nebrida Alan P. 
Published: January 2024

AbstractWireless power transfer (WPT) has garnered significant interest as a potentially transformative technology in the energy sector, as it presents a novel approach to powering and charging devices. The functionality of this technology is predicated upon the utilization of electromagnetic coupling to facilitate the wireless transmission of energy between two entities. Despite the considerable potential, wireless power transfer (WPT) faces significant obstacles that restrict its practical feasibility. One notable challenge that arises is the decrease in power transfer efficiency as the distance between the transmitter and receiver increases. Moreover, the wireless power transfer (WPT) technology is further limited by its reliance on accurate alignment between the transmitting source and the receiving device, thereby posing challenges for its practical implementation. The issues present substantial obstacles to the widespread commercialization of wireless power transfer (WPT). This study seeks to improve the efficacy of power transfer by optimizing the resonance frequency of the power transfer in response to the challenges. By systematically manipulating various parameters including coil dimensions, input voltage levels, and operational frequency, a novel approach is proposed to enhance the efficiency of power transfer. The study additionally offers valuable insights regarding the correlation between the distance separating the coils and the efficiency of power transfer. The findings of this study offer a thorough empirical analysis and are supported by a strong theoretical framework, resulting in a substantial coefficient of determination (R2 = 0.937118). This finding suggests that the linear regression model under consideration could account for approximately 93.7118 percent of the variability observed in the distance. The findings of this study establish a pathway toward enhanced and feasible wireless power technology, thereby establishing a robust basis for the prospective commercial implementation of wireless power transfer (WPT) systems.
Beyond State of the Art: Digital psychiatry is coming of age!
Authors: Riper H. 
Published: January 2024

Abstract
Digital interventions for common mental disorders are coming of age. The uptake of evidence-based self-guided and guided (a-synchronic in time) cognitive behavioural digital interventions for depression and anxiety in routine care is however low. Blended treatment formats appear an attractive alternative for routine care settings as these combine face-to-face sessions with digital ones in integrated treatment protocols. Yet little is known about the clinical and cost-effectiveness of blended CBT (bCBT). In this presentation I will touch upon the current state of the art of digital interventions for depression and anxiety disorders, including blended formats in routine care and I will go beyond that state by addressing new developments. I will illustrate these new developments by virtue of several studies (RCT’s) we conducted on the clinical and cost-effectiveness of blended CBT interventions (and their implementation) in routine care settings. A specific focus will be put on blending digital phenotyping in CBT treatment which includes mobile ecological momentary assessment tools and AI algorithms.

Conclusion
While digital mental health for depression and anxiety in routine care was boosted through the Covid-19 pandemic, the question remains whether the current knowledge base will leveraging digital mental health research and services to the next level. Implications for future research on blended treatments and clinical applications in routine care will be discussed.

Disclosure of Interest
None Declared
Microbiome-gut-brain axis in Nutritional Psychiatry
Authors: Schellekens H. 
Published: January 2024

Abstract
The last decade has seen an enormous expansion on our knowledge of the human gut microbiome and its importance for human physiology. The gastrointestinal inhabitants have taken centre stage as regulators of the bidirectional gut to brain communication. The gut microbiota is not only critical for metabolism, glucose homeostasis and body composition, but increasing evidence is demonstrating the significant effects of the gut microbiota on mood and mental wellbeing and its role in the development of affective disorders, such as anxiety and depression, and other neuropsychiatric conditions. Studies in the field of nutritional neuroscience and nutritional psychiatry are now increasingly including the gut microbiota as a key factor mediating the impact of diet on central nervous system function. Accumulating evidence from cell-based in vitro studies, animal models and preclinical intervention studies are linking the gut microbiota to the effects of diet on brain function, but the precise mechanism are still not fully understood and studies have had limited translation to human intervention studies. Overall, the increase in our understanding of interconnectedness of the gastrointestinal microbiota of human health and disease, has led to a strong focus on the development of microbiota-targeted strategies to influence all host physiological responses, including those that can modulate central nervous system function. In this talk, I will provide an overview of the most recent advances in the nutritional psychiatry–microbiome field, highlighting significant opportunities for future research.

Disclosure of Interest
None Declared
Cost-Effectiveness of eRAPID eHealth Intervention for Symptom Management During Chemotherapy
Authors: Dawkins Bryony , Absolom Kate , Hewison Jenny , Warrington Lorraine , Hudson Eleanor , Holch Patricia , Carter Robert , Gibson Andrea , Holmes Marie , Rogers Zoe , Dickinson Sarah , Morris Carolyn , Woroncow Barbara , Brown Julia , Hulme Claire , Velikova Galina 
Published: January 2024

PURPOSE A randomized controlled trial of online symptom monitoring during chemotherapy with electronic patient self-Reporting of Adverse-events: Patient Information and aDvice (eRAPID) system found improved symptom control and patient self-efficacy, without increasing hospital admissions and visits. The aim of this study was to evaluate the cost-effectiveness of the eRAPID eHealth intervention compared with usual care for patients receiving systemic treatment for colorectal, breast, or gynecologic cancers in the United Kingdom. METHODS An embedded economic evaluation was conducted alongside the trial evaluating the effectiveness of eRAPID from health care provider and societal perspectives. Costs and quality-adjusted life-years (QALYs) of patients were compared over 18 weeks of the trial. Incremental cost-effectiveness ratios (ICERs) were estimated and compared with the National Institute for Health and Care Excellence cost-effectiveness threshold. Uncertainty around the ICER was explored using nonparametric bootstrapping and sensitivity analyses. Follow-up data were collected 12-months after random assignment for a subset of the study sample to conduct exploratory analysis of potential longer-term effects. RESULTS Patients in the eRAPID group had the highest QALY gain and lowest costs over 18 weeks. Although differences were small and not statistically significant, eRAPID had a 55%-58% probability of being more cost-effective than usual care. Patient out-of-pocket costs were lower in the eRAPID group, indicating eRAPID may help patients access support needed within the National Health Service. Exploratory 12-months analysis showed small differences in costs and QALYs, with higher QALY gains in the eRAPID group but also higher costs. Exploratory subgroup analysis by disease status indicated that the eRAPID intervention was cost-effective for patients with early-stage cancers but not for patients with metastatic disease. CONCLUSION Despite small differences in QALYs and costs, the analyses show potential cost-effectiveness of online symptom monitoring, when added to usual care, particularly during adjuvant systemic treatment for early-stage cancers.
Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model
Authors: Saadeddin Anas , Purohit Vivek , Huh Yeamin , Wong Mei , Maulny Aurelia , Dowty Martin E. , Sagawa Kazuko 
Published: January 2024

AbstractRitlecitinib, an orally available Janus kinase 3 and tyrosine kinase inhibitor being developed for the treatment of alopecia areata (AA), is highly soluble across the physiological pH range at the therapeutic dose. As such, it is expected to dissolve rapidly in any in vitro dissolution conditions. However, in vitro dissolution data showed slower dissolution for 100-mg capsules, used for the clinical bioequivalence (BE) study, compared with proposed commercial 50-mg capsules. Hence, a biowaiver for the lower 50-mg strength using comparable multimedia dissolution based on the f2 similarity factor was not possible. The in vivo relevance of this observed in vitro dissolution profile was evaluated with a physiologically based pharmacokinetic (PBPK) model. This report describes the development, verification, and application of the ritlecitinib PBPK model to translate observed in vitro dissolution data to an in vivo PK profile for ritlecitinib capsule formulations. Virtual BE (VBE) trials were conducted using the Simcyp VBE module, including the model-predicted within-subject variability or intra-subject coefficient of variation (ICV). The results showed the predicted ICV was predicted to be smaller than observed clinical ICV, resulting in a more optimistic BE risk assessment. Additional VBE assessment was conducted by incorporating clinically observed ICV. The VBE trial results including clinically observed ICV demonstrated that proposed commercial 50-mg capsules vs clinical 100-mg capsules were bioequivalent, with > 90% probability of success. This study demonstrates a PBPK model–based biowaiver for a clinical BE study while introducing a novel method to integrate clinically observed ICV into VBE trials with PBPK models. Trial registration: NCT02309827, NCT02684760, NCT04004663, NCT04390776, NCT05040295, NCT05128058.
Graphical Abstract
Humanin Treatment Protects Against Venetoclax-Induced Bone Growth Retardation in Ex Vivo Cultured Rat Bones
Authors: Velentza Lilly , Wickström Malin , Kogner Per , Ohlsson Claes , Zaman Farasat , Sävendahl Lars 
Published: January 2024

Abstract

Context
Recent preclinical studies reported that the BCL-2 inhibitor venetoclax can impair bone growth. A strategy to prevent such a side effect of this promising anticancer drug is highly desired. Earlier in vitro and in vivo studies suggested that the mitochondrial peptide humanin has the potential to prevent drug-induced growth impairment.

Objective
We hypothesized that co-treatment with the humanin analog HNG may prevent venetoclax-induced bone growth impairment.

Methods
Ex vivo studies were performed in fetal rat metatarsal bones and human growth plate samples cultured for 12 and 2 days, respectively, while in vivo studies were performed in young neuroblastoma mice being treated daily for 14 days. The treatment groups included venetoclax, HNG, venetoclax plus HNG, or vehicle. Bone growth was continuously monitored and at the end point, histomorphometric and immunohistochemical analyses were performed in fixed tissues.

Results
Venetoclax suppressed metatarsal bone growth and when combined with HNG, bone growth was rescued and all histological parameters affected by venetoclax monotherapy were normalized. Mechanistic studies showed that HNG downregulated the pro-apoptotic proteins Bax and p53 in cultured metatarsals and human growth plate tissues, respectively. The study in a neuroblastoma mouse model confirmed a growth-suppressive effect of venetoclax treatment. In this short-term in vivo study, no significant bone growth-rescuing effect could be verified when testing HNG at a single dose. We conclude that humanin dose-dependently protects ex vivo cultured metatarsal bones from venetoclax-induced bone growth impairment by restoring the growth plate microstructure.
Innervation of the pancreas in development and disease
Authors: Agerskov Rikke Hoegsberg , Nyeng Pia 
Published: January 2024

ABSTRACT
The autonomic nervous system innervates the pancreas by sympathetic, parasympathetic and sensory branches during early organogenesis, starting with neural crest cell invasion and formation of an intrinsic neuronal network. Several studies have demonstrated that signals from pancreatic neural crest cells direct pancreatic endocrinogenesis. Likewise, autonomic neurons have been shown to regulate pancreatic islet formation, and have also been implicated in type I diabetes. Here, we provide an overview of recent progress in mapping pancreatic innervation and understanding the interactions between pancreatic neurons, epithelial morphogenesis and cell differentiation. Finally, we discuss pancreas innervation as a factor in the development of diabetes.
Continuity of Care Increases Physician Productivity in Primary Care
Authors: Kajaria-Montag Harshita , Freeman Michael , Scholtes Stefan 
Published: January 2024

Continuity of care, defined as an ongoing therapeutic relationship between a patient and a physician, is a defining characteristic of primary care. However, arranging a consultation with one’s regular doctor is increasingly difficult as practices face physician shortages. We study the effect of declining care continuity on the productivity of physicians by analyzing data of over 10 million consultations in 381 English primary care practices over a period of 11 years. Specifically, we examine whether a consultation with the patient’s regular doctor is more productive than with another doctor in the practice. Using statistical models that account for confounding and selection bias and restricting the sample to consultations with patients who had at least three consultations over the past two years, we find that the time to a patient’s next visit is on average 18.1% (95% confidence interval: 16.9%, 19.2%) longer when the patient sees the doctor they have seen most frequently over the past two years, while there is no operationally meaningful difference in consultation duration. The data show that the productivity benefit of care continuity is larger for older patients, patients with multiple chronic conditions, and patients with mental health conditions. We estimate that the total consultation demand in our sample could have fallen by up to 5.2% had all practices offered continuity of care at the level of the top decile of practices while prioritizing patients expected to yield the largest productivity benefits. We discuss operational and strategic implications of these findings for primary care practices and for third-party payers. This paper was accepted by David Simchi-Levi, healthcare management. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.02015 .
Hemichorea in patients with temporal lobe infarcts: Two case reports
Authors: Wang Xu-Dong , Li Xing , Pan Chun-Lian 
Published: January 2024

BACKGROUND
Hemichorea and other hyperkinetic movement disorders are uncommon presentations of stroke and are usually secondary to deep infarctions affecting the basal ganglia and thalamus. Therefore, temporal ischemic lesions causing hemichorea are rare. We report the cases of two patients with acute ischemic temporal lobe infarct strokes that presented as hemichorea.
CASE SUMMARY
Patient 1: An 82-year-old woman presented with a 1-mo history of involuntary movement of the left extremity, which was consistent with hemichorea. Her diffusion-weighted imaging (DWI) revealed an acute ischemic stroke that predominantly affected the right temporal cortex, and magnetic resonance angiography of the head showed significant stenosis of the right middle cerebral artery (MCA). Treatment with 2.5 mg of olanzapine per day was initiated. When she was discharged from the hospital, her symptoms appeared to have improved compared with those previously observed. Twenty-seven days after the first admission, she was readmitted due to acute ischemic stroke. Computed tomography perfusion showed marked hypoperfusion in the right MCA territory. An emergency transfemoral cerebral angiogram was performed and showed severe stenosis in the M1 segment of the right MCA. After percutaneous transluminal angioplasty was successfully performed, abnormal movements or other neurologic problems did not occur. Patient 2: A 76-year-old man was admitted to our hospital for a 7-d history of right-upper-sided involuntary movements. DWI showed an acute patchy ischemic stroke in the left temporal lobe without basal ganglia involvement. Subsequent diffusion tensor imaging confirmed fewer white matter fiber tracts on the left side than on the opposite side. Treatment with 2.5 mg of olanzapine per day improved his condition, and he was discharged.
CONCLUSION
When acute hemichorea suddenly appears, temporal cortical ischemic stroke should be considered a possible diagnosis. In addition, hemichorea may be a sign of impending cerebral infarction with MCA stenosis.
Pedicled abdominal flap using deep inferior epigastric artery perforators for forearm reconstruction: A case report
Authors: Jeon Jae Hyung , Kim Kyung Wook , Jeon Hong Bae 
Published: January 2024

BACKGROUND
Pedicled abdominal flaps are a widely used surgical technique for forearm reconstruction in patients with soft tissue defects. However, some drawbacks include restricted flap size, partial flap loss, and donor-site morbidity. To address these concerns, we present a case of a pedicled abdominal flap using the deep inferior epigastric artery perforators (DIEP) for forearm reconstruction in a patient with a large soft tissue defect.
CASE SUMMARY
A 46-year-old male patient was admitted to our hospital with forearm injury caused by a pressing machine. A 15 cm × 10 cm soft tissue defect with complete rupture of the ulnar side structures of the forearm was found. One week after orthopedic management of the neurovascular injury and fractures using the first stage of Masquelet technique, the patient was referred to the plastic and reconstructive surgery department for wound coverage. Surgical debridement and negative-pressure wound therapy revealed a 20 cm × 15 cm soft tissue defect. A pedicle abdominal flap with the DIEP was used to cover the defect. Three weeks later, the flap was detached from the abdomen, and the abdominal defect was directly closed. Subsequently, the second stage of Masquelet technique was performed at the fracture site at week 10. Finally, all donor and recipient sites healed without complications, such as flap dehiscence, infection, hematoma, or necrosis. Fracture site osteosynthesis was achieved without complications.
CONCLUSION
Pedicled abdominal flap using the DIEP provides a reliable option for forearm reconstruction in patients with large soft tissue defects.
Supplemental information for "Performance Evaluation of Jerusalem Artichoke Digging Tool in Cohesive Soil Using Discrete Element Method"
Authors: Awuah Emmanuel , Zhou Jun , Aikins Kojo Atta , Antille Diogenes L. , Liang Zian , Gbenontin Bertrand Vigninou , Makange Nelson Richard 
Published: January 2024

<p>The data includes additional figures and tables referenced in the manuscript. </p>
English loanwords and the presence of hesitation phenomena in speech of European Spanish an Mexican speakers an approach
Authors: Illésné Weeber Ágnes 
Published: January 2024

This article analyses the prosodic adaptation of Anglicisms in a spontaneous speech context by native European Spanish and Mexican speakers. The change of code between languages ​​may carry prosodic markers (Navracsics, 2014), which can be a disfluency phenomenon, such as a short pause or syllable lengthening for hesitation — these being the two most common hesitation patterns (Deme & Markó, 2013). The research has been conducted on filled pauses and lengthening of the Spanish and Mexican language varieties, based on audio corpus of native Spanish and Mexican speakers, following Cantero’s method of Prosodic Analysis of Speech (2019) with modest changes.
In this preliminary study, we have found that hesitation can be observed in the context of Anglicisms in the majority of both Mexican and Spanish speech productions, but a difference was discovered in its placement within the sentence. Furthermore, according to the sample, the relative syllable lengths of European Spanish speakers on a lengthened syllable differ more from the previous or the average syllable length of the speaker than in the case of slower Mexican speakers, where it is not always an obviously detectable phenomenon. Therefore, the decrease of speech rate around Anglicisms in the case of European Spanish speakers is more noticeable. Although longer syllables were also observed on Anglicisms themselves, the extent of this prolongation differed from the degree of syllables containing the hesitation phenomenon, and was probably caused only by the slower articulation of consonant clusters characteristic of Anglicisms.