bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of exercise performance in heart failure patients with extremely reduced cardiac output and left ventricular assist device
Authors: Apostolo Anna , Vignati Carlo , Cittar Marco , Baracchini Nikita , Mushtaq Saima , Cattadori Gaia , Sciomer Susanna , Trombara Filippo , Piepoli Massimo , Agostoni Piergiuseppe 
Published: October 2023

Abstract
The evaluation of exercise capacity and cardiac output (QC) is fundamental in the management of patients with advanced heart failure (AdHF). QC and peak oxygen uptake (VO2) have a pivotal role in the prognostic stratification and in the definition of therapeutic interventions, including medical therapies and devices, but also specific treatments such as heart transplantation and left ventricular assist device (LVAD) implantation. Due to the intertwined relationship between exercise capacity and daily activities, exercise intolerance dramatically has impact on the quality of life of patients. It is a multifactorial process that includes alterations in central and peripheral haemodynamic regulation, anaemia and iron deficiency, pulmonary congestion, pulmonary hypertension, and peripheral O2 extraction. This paper aims to review the pathophysiological background of exercise limitations in HF patients and to examine the complex physiology of exercise in LVAD recipients, analysing the interactions between the cardiopulmonary system, the musculoskeletal system, the autonomic nervous system, and the pump. We performed a literature review to highlight the current knowledge on this topic and possible interventions that can be implemented to increase exercise capacity in AdHF patients—including administration of levosimendan, rehabilitation, and the intriguing field of LVAD speed changes. The present paper confirms the role of CPET in the follow-up of this peculiar population and the impact of exercise capacity on the quality of life of AdHF patients.
Comparative cost-effectiveness of contemporary treatment strategies for stage IIA seminoma
Authors: Joyce Daniel D , Sharma Vidit , Wymer Kevin M , Moriarty James P , Borah Bijan J , Walia Arman , Costello Brian A , Pagliaro Lance C , Daneshmand Siamak , Leibovich Bradley C , Boorjian Stephen A 
Published: October 2023

Abstract

Background
The Surgery in Early Metastatic Seminoma (SEMS) trial examined retroperitoneal lymph node dissection as first-line treatment for patients with isolated 1-3 cm retroperitoneal lymphadenopathy. To date, the standard of care for these patients has been either chemotherapy or radiotherapy. Herein, we evaluated the relative cost-effectiveness of these management strategies.

Methods
A microsimulation model assessed the cost-effectiveness of retroperitoneal lymph node dissection, chemotherapy, and radiotherapy for stage IIA seminoma. Sensitivity analyses were performed to evaluate model robustness. Retroperitoneal lymph node dissection recurrence probabilities were obtained from the SEMS trial. All other probability and utility values were obtained from published literature. Primary outcomes included costs from a commercial insurer’s perspective, effectiveness (quality adjusted life-years [QALYs]), and incremental cost-effectiveness ratios using a willingness-to-pay threshold of $100 000/QALY.

Results
At a lifetime horizon, the mean costs per patient for retroperitoneal lymph node dissection, radiotherapy, and chemotherapy were $58 469, $98 783, and $104 096, and the mean QALYs were 40.61, 40.70, and 39.15, respectively. Retroperitoneal lymph node dissection was found to be the most cost-effective approach because of high costs and accrued disutility of chronic toxicities associated with radiotherapy (cost-effectiveness ratios = $433 845/QALY) and chemotherapy (dominated). On 1-way sensitivity analyses, retroperitoneal lymph node dissection was no longer cost-effective if the probabilities of infertility and cardiovascular toxicity after radiotherapy were less than 13% and 16%, respectively, or if the 2-year probability of progression after retroperitoneal lymph node dissection was more than 26%.

Conclusions
Retroperitoneal lymph node dissection was the most cost-effective treatment approach for stage IIA seminoma. These findings support clinical guideline consideration of including retroperitoneal lymph node dissection as a treatment option for well-selected patients with stage IIA seminoma.
Categorising the world into local climate zones: towards quantifying labelling uncertainty for machine learning models
Authors: Hechinger Katharina , Zhu Xiao Xiang , Kauermann Göran 
Published: October 2023

AbstractImage classification is often prone to labelling uncertainty. To generate suitable training data, images are labelled according to evaluations of human experts. This can result in ambiguities, which will affect subsequent models. In this work, we aim to model the labelling uncertainty in the context of remote sensing and the classification of satellite images. We construct a multinomial mixture model given the evaluations of multiple experts. This is based on the assumption that there is no ambiguity of the image class, but apparently in the experts’ opinion about it. The model parameters can be estimated by a stochastic expectation maximisation algorithm. Analysing the estimates gives insights into sources of label uncertainty. Here, we focus on the general class ambiguity, the heterogeneity of experts, and the origin city of the images. The results are relevant for all machine learning applications where image classification is pursued and labelling is subject to humans.
Environmental context of phenotypic plasticity in flowering time in sorghum and rice
Authors: Guo Tingting , Wei Jialu , Li Xianran , Yu Jianming 
Published: October 2023

Abstract
Phenotypic plasticity is an important topic in biology and evolution. However, how to generate broadly applicable insights from individual studies remains a challenge. Here, with flowering time observed from a large geographical region for sorghum and rice genetic populations, we examine the consistency of parameter estimation for reaction norms of genotypes across different subsets of environments and searched for potential strategies to inform the study design. Both sample size and environmental mean range of the subset affected the consistency. The subset with either a large range of environmental mean or a large sample size resulted in genetic parameters consistent with the overall pattern. Furthermore, high accuracy through genomic prediction was obtained for reaction norm parameters of untested genotypes using models built from tested genotypes under the subsets of environments with either a large range or a large sample size. With 1428 and 1674 simulated settings, our analyses suggested that the distribution of environmental index values of a site should be considered in designing experiments. Overall, we showed that environmental context was critical, and considerations should be given to better cover the intended range of the environmental variable. Our findings have implications for the genetic architecture of complex traits, plant–environment interaction, and climate adaptation.
Dust from evolved stars: a pilot analysis of the AGB to PN transition
Authors: Dell’Agli F , Tosi S , Kamath D , Stanghellini L , Bianchi S , Ventura P , Marini E , García-Hernández D A 
Published: October 2023

ABSTRACT
We present a novel approach to address dust production by low- and intermediate-mass stars. We study the asymptotic giant branch (AGB) phase, during which the formation of dust takes place, from the perspective of post-AGB and planetary nebula (PN) evolutionary stage. Using results from stellar evolution and dust formation modelling, we interpret the spectral energy distribution of carbon-dust-rich sources currently evolving through different evolutionary phases, believed to descend from progenitors of similar mass and chemical composition. Comparing the results of different stages along the AGB to PNe transition, we can provide distinct insights on the amount of dust and gas released during the very late AGB phases. While the post-AGB traces the history of dust production back to the tip of the AGB phase, investigating the PNe is important to reconstruct the mass-loss process experienced after the last thermal pulse. The dust surrounding the post-AGB was formed soon after the tip of the AGB. The PNe dust-to-gas ratio is ∼10−3, 2.5 times smaller than what expected for the same initial mass star during the last AGB interpulse, possibly suggesting that dust might be destroyed during the PN phase. Measuring the amount of dust present in the nebula can constrain the capacity of the dust to survive the central star heating.
Investigation on the orbital period variations of NN Ser: implications for the hypothetical planets, the Applegate mechanism, and the orbital stability
Authors: Özdönmez Aykut , Er Huseyin , Nasiroglu Ilham 
Published: October 2023

ABSTRACT
We present 36 new mid-eclipse times obtained between 2017 and 2023 using the T100 telescope in Turkey, extending the time span of the O − C diagram to 25 yr. Once again, these new observations show significant deviations from previous published models that were able to explain the observed variations of the binary period. We investigate two plausible explanations for this variability: the light travel time (LTT) effect due to the presence of one or two invisible low-mass (planetary) companion(s) in distant circumbinary orbits; other mechanisms, like e.g. the Applegate mechanism, associated with the magnetic cycles of the M-dwarf component of the WD + dM binary. Through Markov Chain Monte Carlo analyses, we demonstrate that the observed O − C variability can be explained by the presence of a planet with a minimum mass of ∼9.5MJ. This circumbinary planet orbits around the binary system with a period of about 19.5 yr, maintaining a stable orbit for a timeline of 10 Myr. By adding a weak LTT signal from a secondary hypothetical planet we achieve statistically better results. However, the orbits of the bodies in a two-planet system remain stable only for a small range of the parameter space. The energy required to power the Applegate and other Applegate-like mechanisms is too high to explain the period variations observed. Thus, on the one hand there is substantial evidence supporting the existence of a planet in the NN Ser system, but on the other hand there are also compelling indications that cast doubt on the existence of a second hypothetical planet.
Azimuthal anisotropy of magnetic fields in the circumgalactic medium driven by galactic feedback processes
Authors: Ramesh Rahul , Nelson Dylan , Heesen Volker , Brüggen Marcus 
Published: October 2023

ABSTRACT
We use the TNG50 cosmological magnetohydrodynamical simulation of the IllustrisTNG project to show that magnetic fields in the circumgalactic medium (CGM) have significant angular structure. This azimuthal anisotropy at fixed distance is driven by galactic feedback processes that launch strong outflows into the halo, preferentially along the minor axes of galaxies. These feedback-driven outflows entrain strong magnetic fields from the interstellar medium, dragging fields originally amplified by small-scale dynamos into the CGM. At the virial radius, z = 0 galaxies with M⋆ ∼ $10^{10}\, \rm {M_\odot }$ show the strongest anisotropy (∼0.35 dex). This signal weakens with decreasing impact parameter, and is also present but weaker for lower mass as well as higher mass galaxies. Creating mock Faraday rotation measure (RM) sightlines through the simulated volume, we find that the angular RM trend is qualitatively consistent with recent observational measurements. We show that rich structure is present in the circumgalactic magnetic fields of galaxies. However, TNG50 predicts small RM amplitudes in the CGM that make detection difficult as a result of other contributions along the line of sight.
The FLAMINGO project: revisiting the S8 tension and the role of baryonic physics
Authors: McCarthy Ian G , Salcido Jaime , Schaye Joop , Kwan Juliana , Elbers Willem , Kugel Roi , Schaller Matthieu , Helly John C , Braspenning Joey , Frenk Carlos S , van Daalen Marcel P , Vandenbroucke Bert , Conley Jonah T , Font Andreea S , Upadhye Amol 
Published: October 2023

ABSTRACT
A number of recent studies have found evidence for a tension between observations of large-scale structure (LSS) and the predictions of the standard model of cosmology with the cosmological parameters fit to the cosmic microwave background (CMB). The origin of this ‘S8 tension’ remains unclear, but possibilities include new physics beyond the standard model, unaccounted for systematic errors in the observational measurements and/or uncertainties in the role that baryons play. Here, we carefully examine the latter possibility using the new FLAMINGO suite of large-volume cosmological hydrodynamical simulations. We project the simulations onto observable harmonic space and compare with observational measurements of the power and cross-power spectra of cosmic shear, CMB lensing, and the thermal Sunyaev-Zel’dovich (tSZ) effect. We explore the dependence of the predictions on box size and resolution and cosmological parameters, including the neutrino mass, and the efficiency and nature of baryonic ‘feedback’. Despite the wide range of astrophysical behaviours simulated, we find that baryonic effects are not sufficiently large to remove the S8 tension. Consistent with recent studies, we find the CMB lensing power spectrum is in excellent agreement with the standard model, while the cosmic shear power spectrum, tSZ effect power spectrum, and the cross-spectra between shear, CMB lensing, and the tSZ effect are all in varying degrees of tension with the CMB-specified standard model. These results suggest that some mechanism is required to slow the growth of fluctuations at late times and/or on non-linear scales, but that it is unlikely that baryon physics is driving this modification.
Cold dust and low [O iii]/[C ii] ratios: an evolved star-forming population at redshift 7
Authors: Algera Hiddo S B , Inami Hanae , Sommovigo Laura , Fudamoto Yoshinobu , Schneider Raffaella , Graziani Luca , Dayal Pratika , Bouwens Rychard , Aravena Manuel , da Cunha Elisabete , Ferrara Andrea , Hygate Alexander P S , van Leeuwen Ivana , De Looze Ilse , Palla Marco , Pallottini Andrea , Smit Renske , Stefanon Mauro , Topping Michael , van der Werf Paul P 
Published: October 2023

ABSTRACT
We present new ALMA Band 8 (rest-frame $90 \ \mu$m) continuum observations of three massive ($M_\star \approx 10^{10}\ \mathrm{ M}_\odot$) galaxies at z ≈ 7 previously detected in [C ii]$158 \ \mu$m and underlying dust continuum emission in the Reionization Era Bright Emission Line Survey (REBELS). We detect dust emission from two of our targets in Band 8 (REBELS-25 and REBELS-38), while REBELS-12 remains undetected. Through optically thin modified blackbody fitting, we determine dust temperatures of $T_\mathrm{dust}\approx 30-35\,$ K in both of the dual-band detected targets, indicating they are colder than most known galaxies at z ∼ 7. Moreover, their inferred dust masses are large ($M_\mathrm{dust}\approx 10^{8}\ \mathrm{ M}_\odot$), albeit still consistent with models of high-redshift dust production. We furthermore target and detect [O iii]$88 \ \mu$m emission in both REBELS-12 and REBELS-25, and find $L_\mathrm{[O\, III]}/L_\mathrm{[C\, II]}\approx 1-1.5$ – low compared to the $L_\mathrm{[O\, \rm{\small III}]}/L_\mathrm{[C\, \rm{\small II}]}\gtrsim 2-10$ observed in the known z ≳ 6 population thus far. We argue the lower line ratios are due to a comparatively weaker ionizing radiation field resulting from the less starbursty nature of our targets, although the possibility of REBELS-12 being a merger of an [O iii]-bright and [O iii]-faint component prevents the unambiguous interpretation of its [O iii]/[C ii] ratio. Nevertheless, a low burstiness forms a natural explanation for the cold dust temperatures and low $\mathrm{[O\, \rm{\small III}]}\lambda \lambda 4959,5007+\mathrm{H} \, \beta$ equivalent widths of REBELS-25 and REBELS-38. Overall, these observations provide evidence for the existence of a massive, dust-rich galaxy population at z ≈ 7 which has previously experienced vigorous star formation, but is currently forming stars in a steady, as opposed to bursty, manner.
The importance of small joint involvement in oligoarticular juvenile idiopathic arthritis
Authors: Kaplan Melike Mehveş , Ekici Tekin Zahide , Güngörer Vildan , Çelikel Elif , Kurt Tuba , Polat Merve Cansu , Sezer Müge , Tekgöz Nilüfer , Karagöl Cüneyt , Coşkun Serkan , Öner Nimet , Çelikel Acar Banu 
Published: October 2023

ABSTRACT

Objectives
Our study aimed to evaluate the relationship of small joint involvement with demographic, clinical, and laboratory findings and to determine its possible effects on prognosis.

Methods
This retrospective observational study was conducted in patients diagnosed with oligoarticular juvenile idiopathic arthritis (oJIA) in the paediatric rheumatology department of Ankara City Hospital between April 2009 and September 2022. The relationship between small joint involvement and demographic, clinical, and laboratory findings and prognosis was investigated by statistical methods with the data recorded from the medical records of oJIA patients.

Results
Of the 198 patients diagnosed with oJIA, small joint involvement was observed in a total of 20 (10%) patients, 11 (5.5%) at the time of diagnosis, and 9 (4.5%) during the follow-up period. The frequency of small joint involvement in extended oJIA was significantly higher than in persistent oJIA (P = .001). Patients with small joint involvement had significantly higher erythrocyte sedimentation rate and C-reactive protein values at admission (P = .047, P = .038) and Juvenile Arthritis Disease Activity Score at 3, 6, and 12 months (P = .001, P = .001, P = .018). The need for conventional disease-modifying antirheumatic drugs and biologic disease-modifying antirheumatic drugs was significantly higher in patients with small joint involvement (P = .001, P = .001).

Conclusions
oJIA patients with small joint involvement may have higher acute phase reactants at diagnosis, a more extended course and active disease in follow-up, and the need for treatment escalation.
MAMI: a comprehensive database of mother–infant microbiome and probiotic resources
Authors: Zhou Tian , Xiao Liwen , Zuo Zhenqiang , Zhao Fangqing 
Published: October 2023

Abstract
Extensive evidence has demonstrated that the human microbiome and probiotics confer great impacts on human health, particularly during critical developmental stages such as pregnancy and infancy when microbial communities undergo remarkable changes and maturation. However, a major challenge in understanding the microbial community structure and interactions between mothers and infants lies in the current lack of comprehensive microbiome databases specifically focused on maternal and infant health. To address this gap, we have developed an extensive database called MAMI (Microbiome Atlas of Mothers and Infants) that archives data on the maternal and neonatal microbiome, as well as abundant resources on edible probiotic strains. By leveraging this resource, we can gain profound insights into the dynamics of microbial communities, contributing to lifelong wellness for both mothers and infants through precise modulation of the developing microbiota. The functionalities incorporated into MAMI provide a unique perspective on the study of the mother–infant microbiome, which not only advance microbiome-based scientific research but also enhance clinical practice. MAMI is publicly available at https://bioinfo.biols.ac.cn/mami/.
H3K27M mutant glioma: Disease definition and biological underpinnings
Authors: Saratsis Amanda M , Knowles Truman , Petrovic Antonela , Nazarian Javad 
Published: October 2023

Abstract
High-grade glioma (HGG) is the most common cause of cancer death in children and the most common primary central nervous system tumor in adults. While pediatric HGG was once thought to be biologically similar to the adult form of disease, research has shown these malignancies to be significantly molecularly distinct, necessitating distinct approaches to their clinical management. However, emerging data have shown shared molecular events in pediatric and adult HGG including the histone H3K27M mutation. This somatic missense mutation occurs in genes encoding one of two isoforms of the Histone H3 protein, H3F3A (H3.3), or HIST1H3B (H3.1), and is detected in up to 80% of pediatric diffuse midline gliomas and in up to 60% of adult diffuse gliomas. Importantly, the H3K27M mutation is associated with poorer overall survival and response to therapy compared to patients with H3 wild-type tumors. Here, we review the clinical features and biological underpinnings of pediatric and adult H3K27M mutant glioma, offering a groundwork for understanding current research and clinical approaches for the care of patients suffering with this challenging disease.
Cancer of colon, rectum and anus: the rising burden of disease worldwide from 1990 to 2019
Authors: Ilic Milena , Ilic Irena 
Published: October 2023

AbstractBackgroundPrevious studies suggest that trends of cancer of colon, rectum and anus (CRA) incidence and mortality have been decreasing in recent decades. However, the trends are not uniform across age groups. This study aimed to assess the trends of the cancer of CRA burden worldwide.MethodsA descriptive study was carried out with a joinpoint regression analysis using the database of the Global Burden of Disease study.ResultsAbout 2.2 million new cases of cancer of CRA were diagnosed in the world in 2019, whereby cancer of CRA caused ~1.1 million deaths. Globally, the incidence trend in both sexes together was increasing in 1990–2019, while the mortality trend was decreasing. The highest rise both in incidence and mortality was observed in the East Asia region (by 3.6% per year and by 1.4% per year, respectively) and the Andean Latin America region (by 2.7% per year and by 1.2% per year, respectively). However, of particular concern is the significant increase in the incidence (by 1.7% per year) and mortality (by 0.5% per year) from cancer of CRA in people aged 15–49.ConclusionsUnfavorable trends in cancer of CRA in the young require more attention in management plans.