bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant
Authors: Gilman Andrew L. , Serrano Amy , Skelley John , Zwick David 
Published: August 2005

AbstractWe report the clinical course of a patient who developed a Rhizopus infection of his right lung and pleural cavity, 11 months after receiving a T‐cell‐depleted, haploidentical donor peripheral blood stem cell transplant. Thoracotomy was performed to remove the pulmonary lesion, but residual disease in the pleural cavity was noted. Treatment with amphotericin B was complicated by the development of severe renal dysfunction, necessitating alternative antifungal therapy. Treatment was initiated with the investigational triazole posaconazole. Despite concurrent treatment with corticosteroids for graft‐versus‐host disease (GVHD), the patient had a complete response and remains well 4 years later. © 2005 Wiley‐Liss, Inc.
Reinduction of relapsed acute promyelocytic leukemia with ATRA and low dose antimetabolite‐based chemotherapy
Authors: Dvorak Christopher C. , Sanders Robert P. , Dahl Gary V.H. , Donaldson Sarah S. , Razzouk Bassem I. 
Published: August 2005

AbstractWhile the disease‐free survival of acute promyelocytic leukemia (APML) now approaches 75%, some children continue to experience relapses, and questions remain as to the optimal management of these patients. We describe two young children who experienced combined relapses in the bone marrow and extramedullary locations following hematopoietic stem cell transplantation (HSCT). An induction regimen, consisting of all‐trans retinoic acid (ATRA), methotrexate, and 6‐mercaptopurine (6MP), successfully and safely achieved hematologic remission in one patient and molecular remission in the other. These cases demonstrate that there is a role for ATRA plus differentiating chemotherapy other than arsenic trioxide in the treatment of relapsed APML. Pediatr Blood Cancer 2007;48:582–585. © 2005 Wiley‐Liss, Inc.
Synthesis of new photoresponsive polyesters containing norbornadiene moieties by the ring‐opening copolymerization of donor–acceptor norbornadiene dicarboxylic acid anhydride with donor–acceptor norbornadiene dicarboxylic acid monoglycidyl ester derivatives
Authors: Ono Yoshitomo , Kawashima Naoyuki , Kudo Hiroto , Nishikubo Tadatomi , Nagai Takabumi 
Published: August 2005

AbstractThe ring‐opening copolymerization of donor–acceptor norbornadiene (D–A NBD) dicarboxylic acid monoglycidyl ester derivatives with D–A NBD dicarboxylic acid anhydride was performed with tetraphenylphosphonium bromide as a catalyst in toluene to produce new norbornadiene (NBD) polyesters containing D–A NBD moieties in the main chain and in the side chain in one step in good yields. The photoisomerization of the D–A NBD moieties in these polyesters proceeded very smoothly to give the corresponding quadricyclane groups. Because these NBD polyesters contained many NBD moieties in the polymer chain, they had the highest capacity for heat storage in the D–A NBD polymers reported so far. The stored thermal energy of the irradiated polyesters was evaluated by differential scanning calorimetry analysis to be approximately 150–190 J/g. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 4412–4421, 2005
Ring‐opening polymerizations of propylene oxide by double metal cyanide catalysts prepared with ZnX2 (X = F, Cl, Br, or I)
Authors: Kim Il , Byun Seung Hoon , Ha Chang‐Sik 
Published: August 2005

AbstractPolymerizations of propylene oxide were carried out with double metal cyanide (DMC) catalysts based on Zn3[Co(CN)6]2. Through the control of the type and amount of ZnX2 (X = F, Cl, Br, or I) during the preparation of the catalyst, the catalytic activity, induction period, and unsaturation level in the polyether polyols could be tuned. The DMC catalysts were characterized by X‐ray photoelectron spectroscopy, infrared spectroscopy, and X‐ray powder diffraction. In general, ZnBr2 was the most effective zinc halide with respect to the properties of the resulting polymers as well as the activity and induction period. The average rates of polymerizations of DMC catalysts prepared with ZnCl2, ZnBr2, and ZnI2 were 889, 1667, and 784 g of polyoxypropylene/g of catalyst h, respectively, with induction periods of about 53, 5, and 60 min, respectively, at 115 °C. The DMC catalysts produced polyoxypropylenes with an ultralow unsaturation level (0.0025–0.0057 mequiv/g) and a narrow molecular weight distribution (1.07–1.42) without high‐molecular‐weight tails; this resulted in a low viscosity (962–3950 cP). According to the results collected from catalyst characterizations and polymerizations, the active sites of DMC‐catalyzed polymerization had mainly coordinative characters. The presence of free anions accelerated the ring‐opening procedure and thus enhanced the propagation rate and shortened the induction period. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 4393–4404, 2005
Topographic control of periglacial slope covers, Ślęża Massif, southwest Poland: a statistical approach
Authors: Żurawek Roman , Żyszkowski Emil , Górecki Adam 
Published: August 2005

AbstractThe slopes of Mt Ślęża, southwest Poland, are covered by debris covers that consist of gabbro blocks. Six classes of slope covers have been distinguished based on the concentration of blocks. A map of slope covers has been digitized and the following parameters have been defined: (i) concentration of blocks on the slope, (ii) slope inclination, (iii) altitude, and (iv) aspect. The concentration of blocks has no correlation with either aspect or altitude. Instead, a dependence upon slope inclination is found. This suggests that slopewash explains the distribution of blocks on the present surface. Copyright © 2005 John Wiley & Sons, Ltd.
Ceramide and Cholesterol: Possible Connections Between Normal Aging of the Brain and Alzheimer's Disease. Just hypotheses or molecular pathways to be identified?
Authors: Costantini Claudio , Kolasani Rekha M.K. , Puglielli Luigi 
Published: August 2005

AbstractEven though it is known that aging is the single most important risk factor for Alzheimer's disease (AD), there is a lack of information on the molecular pathway(s) that connect normal aging of the brain to this form of neuropathology. Because of the rise in average lifespan, the number of individuals that reach the seventh or eighth decade of life and become at high risk for AD is rapidly increasing. Current estimations predict that by 2050 about 45 to 50 million individuals will be affected by AD worldwide. Here, we discuss the need for more age‐directed research to understand AD neuropathology. We also elaborate on the possible role of cholesterol and ceramide as molecular connections between aging and AD, and as novel therapeutic targets for the prevention of late‐onset AD.
Pietro Carnesecchi and Cardinal Pole: New Perspectives
Authors: FENLON DERMOT 
Published: August 2005

I processi inquisitoriali di Pietro Carnesecchi (1557–1567). Edizione critica, I: Il processo sotto Paolo IV e Pio IV (1557–1561); II: Il processo sotto Pio V (1566–1567), I: Guigno 1566–ottobre 1566; II: Novembre 1566–gennaio 1567; III: Gennaio 1567–agosto 1567. Edited by Massimo Firpo and Dario Marcatto. (Collectanea Archivi Vaticani, 43.). Pp. cxix+577; Pp. clxxix+370; 371–956; 957–1453. Vatican City: Archivio Segreto Vaticano, 1998, 2000. 88 85042 30 9; 88 85042 34 1The correspondence of Reginald Pole, II: A calendar, 1547–1554. A power in Rome. By Thomas F. Mayer. (St Andrews Studies in Reformation History.) Pp. xvi+410. Aldershot: Ashgate, 2003. £50. 0 7546 0327 XThe judicial investigation of Pietro Carnesecchi by the Roman inquisition in the years 1546–67 constitutes a major chapter in the history of the Italian peninsula and of the Church of Rome. Thanks to the indefatigable energy of Dario Marcatto, the publication of the documents from the archives of the Roman inquisition now places all the available sources at the disposal of the scholarly world. Massimo Firpo's critical introductions to these two volumes builds securely on his previously published essays, which included an account of Carnesecchi based on the edition of 1870. What he now writes confirms and extends his earlier findings.
Expression of Type II and Type XI Collagens in Canine Mammary Mixed Tumors and Demonstration of Collagen Production by Tumor Cells in Collagen Gel Culture
Authors: Aral Katsuhiko , Uehara Kohkichi , Nagai Yutaka 
Published: August 2005

The development of cartilaginous collagen types, II and XI, in canine mammary mixed tumors was studied biochemically and immunohlstochemically. In mixed tumor, an alcian blue‐positive myxomatous region appeared in the stroma, where round‐shaped proliferating myoepithelial cells were scattered. Type II collagen was distributed in metaplastic cartilage matrix, while type XI was located only in the pericellular region, where proliferating cells were positively stained with anti‐actin and anti‐keratin antibodies. The accumulation of collagen types II and XI in the tumor mass was confirmed by sodium do decyl sulfate‐polyacrylamide gel electrophoresis followed by immunoblotting of the extract of the lesion using type‐specific antibodies to collagen types II and XI. Tumor cells isolated from metaplastic tumor mass expressed both collagen types II and XI and myoepithelial types of cytoskeleton in gel culture, in which an alcian blue‐positive substance became detectable in the pericellular region on day 3 and type II and type XI collagens on day 5. This may be a useful model for studying chondrocyte‐type gene expression during tumorigenesis.
Functional Analysis of Mononuclear Cells Infiltrating into Tumors: Establishment of a New System to Obtain Functionally Active Tumor‐infiltrating Cells
Authors: Shijubo Noriharu , Uede Toshimitsu , Nomura Naohiro , Kikuchi Kokichi 
Published: August 2005

ABSTRACTWe have demonstrated that tumor‐infiltrating T cells play a crucial role in tumor growth. In order to investigate the precise function of tumor‐infiltrating cells, we avoided the use of any enzyme for separation of tumor‐infiltrating cells from the solid tumor mass and established a new system in which we could easily obtain functionally active tumor‐infiltrating cells in large amounts from the peritoneal cavity of T‐9 gliosarcoma‐sensitized rats. In this system, viable T‐9 cells were intraperitoneally administered and peritoneal exudate cells were recovered. Importantly, cells obtained from the intraperitoneal cavity are phenotypically and functionally indistinguishable from those obtained from subcutaneous tumor masses. Furthermore, injection of purified lymphocyte migration factor‐b resulted in the accumulation of CD8 (+) cytotoxic T cells in the peritoneal cavity. Therefore, this system also provides a means by which the in vivo function of chemotactic factor can be tested.
Enhancement of the Antibody‐dependent Tumoricidal Activity of Human Monocytes by Human Monocytic Colony‐stimulating Factor
Authors: Suzu Shinya , Yanai Nobuya , Saito Minoru , Kawashima Takuji , Kasahara Tadashi , Saito Masaki , Takaku Fumimaro , Motoyoshi Kazuo 
Published: August 2005

ABSTRACTHuman monocytic colony‐stimulating factor (hM‐CSF) stimulates mature cells as well as progenitor cells of human monocyte lineage. In the present study, we investigated the effect of completely purified native hM‐CSF on the tumoricidal activity of human monocytes against Raji (Burkitt lymphoma‐derived cell line) using a chromium release assay. Preincubation of human peripheral blood monocytes with hM‐CSF for 48 h markedly enhanced their antibody‐dependent cellular cytotoxicity (ADCC). This enhancing effect was dependent on the concentration of hM‐CSF, and maximal enhancement was achieved at the concentration of 66 ng/ml. The number of receptor sites on monocytes against the Fc portion of immunoglobulin G increased 2‐ to 4‐fold during 48 h incubation with hM‐CSF. These results suggest that hM‐CSF stimulates monocyte‐ADCC by increasing the number of Fc receptor sites on human monocytes.
Proposed Distal Margin for Resection of Rectal Cancer
Authors: Kameda Kanji , Furusawa Motonosuke , Mori Masaki , Sugimachi Keizo 
Published: August 2005

ABSTRACTTo determine the adequate distal margin, particularly from the point of extent of lymph node metastasis, 2,333 lymph nodes from 44 patients with rectal carcinoma were evaluated, using a clearing method. The tumors were divided into two growth patterns; infiltrative and localized. Lymph node metastasis was histo‐pathologically examined with special attention focused on nodes on the distal side of the tumor. The intramural spread was also given attention. The proximal pararectal lymph nodes often contained malignant cells, whereas the distal ones were rarely involved, and if involved, they were present within 1 cm from the tumor. Pararectal lymph node metastasis and intramural spread were seen with a range of 1 cm and 0.5 cm, respectively, in the localized type and 1 cm and 2.1 cm, respectively in the infiltrative type. Based on these findings, the distal margin for surgical resection of rectal carcinoma is considered to be 2 cm for the localized type and 3 cm for the infiltrative type.
Cognitive biases toward alcohol‐related words and executive deficits in polysubstance abusers with alcoholism
Authors: Noël Xavier , Van der Linden Martial , D’Acremont Mathieu , Colmant Maud , Hanak Catherine , Pelc Isidore , Verbanck Paul , Bechara Antoine 
Published: August 2005

ABSTRACTAim  To study cognitive biases for alcohol‐related cues on executive function tasks involving mental flexibility and response inhibition in polysubstance abusers with alcoholism.Design  The responses to alcohol‐related cues of detoxified polysubstance abusers with alcoholism and of non‐addicts were compared.Setting  The University of Iowa City, Iowa, USA.Participants  Thirty detoxified polysubstance abusers with alcoholism (PSA) and 30 healthy non‐substance abusers (CONT).Measurements  Using the ‘Alcohol Shifting Task’, a variant of the go/no‐go paradigm, we measured the response times and the accuracy of responses to targets and distracters. Sometimes the alcohol‐related words were the targets for the ‘go’ response, with neutral words as distracters, sometimes the reverse. Several shifts in the type of the target occurred during the task.Findings  Relative to CONT, PSA were generally slower to respond to targets, but the group difference was smaller when alcohol‐related words were the targets. A signal detection analysis also indicated that relative to CONT, the PSA had more difficulties discriminating between targets and distracters (low d′), and they showed more signs of decision bias (low C), reflecting increased readiness to respond to both targets and distracters. However, these discrimination and inhibition deficits were more pronounced when alcohol‐related words were the targets. Furthermore, the weaknesses in RT and C were more pronounced in PSA after shifting the targets from alcohol‐related to neutral words, or vice versa.Conclusions  These results suggest that PSA have cognitive biases towards information related to alcohol, and that these biases, as well as the poor executive functions (lower mental flexibility and response inhibition) revealed in PSA might be responsible for their failure to maintain abstinence.
The effects of alcohol expectancies on drinking behaviour in peer groups: observations in a naturalistic setting
Authors: Bot Sander M. , Engels Rutger C. M. E. , Knibbe Ronald A. 
Published: August 2005

ABSTRACTAims  To study the functionality of alcohol expectancies in predicting drinking behaviour in existing peer groups of young adults in a ‘naturalistic’ setting.Design and setting  Young adults were invited to join an experiment with their peer group in a bar annex laboratory. During a ‘break’ of 50 minutes in this experiment, their activities, social behaviour and drinking behaviour were observed with digital video and audio equipment.Participants  Twenty‐eight peer groups were involved in this study. A peer group consisted of seven to nine people, with relationships ranging from intimate relations and close friendships to being acquaintances. A total of 238 participants were involved.Measurements  Information of the drinking behaviour from observations and questionnaire data on alcohol expectancies provide the opportunity to look at how and which expectancies are related to actual drinking patterns. Multiple regression and multi‐level analyses were applied.Findings  Expectancies on the positive and arousing effects of alcohol consumption were related to alcohol consumption in a naturalistic, social drinking situation, in addition to group effects of drinking. Expectancies on the negative and sedative effects of drinking, however, were not related to drinking.Conclusions  The findings indicate that among young adults observed in a peer group and naturalistic drinking setting, positive expectancies about the effects of alcohol and expectancies about the effects of alcohol on arousal are related positively to drinking level.
Lower cognitive test scores observed in alcohol abstainers are associated with demographic, personality, and biological factors: the PATH Through Life Project
Authors: Anstey Kaarin J. , Windsor Timothy D. , Rodgers Bryan , Jorm Anthony F. , Christensen Helen 
Published: August 2005

ABSTRACTAims  To identify variables that explain the association between alcohol abstention and cognitive performance. We hypothesized that demographic and personality variables would be important for explaining the association in all age  cohorts,  but  that  health  variables  would  be  more  important  in the older age‐cohorts.Design  Three age cohorts (20–24, 40–44, 60–64 years) were sampled randomly, yielding a total of 7485 participants, with data from 602 alcohol abstainers and 4158 light or moderate drinkers used in this study.Setting  The sample was drawn from the cities of Canberra and Queanbeyan, Australia.Measurements  Scales measuring demographic, health and personality variables and cognitive and physical tests were administered. Participants drinking at hazardous or harmful levels were excluded from the analysis.Findings  A range of demographic and physical function measures were found to explain partially the finding of abstainers having lower cognitive test scores. The effects of independent variables were largest in the 60–64‐year‐old age group with a trend for physical variables such as lung function and grip strength to become more important in the older age groups. In the 20–24‐year‐olds, the majority of the effect remained unexplained.Conclusion  There is evidence that poorer cognitive test performance by abstainers reflects in part selection effects and poorer physical functioning, but does not appear to be due to mental or physical health conditions or personality.
Prevalence and predictors of research participant eligibility criteria in alcohol treatment outcome studies, 1970–98
Authors: Humphreys Keith , Weingardt Kenneth R. , Horst Doyanne , Joshi Asha A. , Finney John W. 
Published: August 2005

ABSTRACTAims  To describe the eligibility criteria (i.e. study participant inclusion and exclusion rules) employed in alcohol treatment outcome research and to identify predictors of their use.Design  The eligibility criteria of 683 alcohol treatment outcome studies conducted between 1970 and 1998 were coded reliably into 14 general categories. Predictors of the use of eligibility criteria were then examined.Findings  Patients were most often ruled ineligible for research studies because of their level of alcohol problems (39.1% of studies), comorbid psychiatric problems (37.8%),  past  or  concurrent  utilization  of  alcohol  treatment  (31.8%),  co‐occurring  medical  conditions  (31.6%),  and  because  they  were  deemed  non‐compliant and unmotivated (31.5%). The number of eligibility criteria employed in studies increased from the 1970s through the 1990s, and was positively associated with funding from the US National Institute of Alcohol Abuse and Alcoholism (NIAAA) and from the private sector, lack of an inpatient/residential treatment condition, presence of a pharmacotherapy, and use of a randomized, multiple‐condition design. Principal investigators with doctoral degrees used more eligibility criteria than those with lower degrees.Conclusion  Participant eligibility criteria are extensively employed in alcohol treatment outcome research, and vary significantly across historical periods, funders and research designs. Researchers should report the details of subject eligibility criteria and excluded patients more fully, and, evaluate how eligibility criteria affect the cost, feasibility, and generalizability of treatment outcome research.
An examination of early smoking experiences and smoking status in a national cross‐sectional sample
Authors: O'Connor Richard J. , Kozlowski Lynn T. , Vandenbergh David J. , Strasser Andrew A. , Grant Michael D. , Vogler George P. 
Published: August 2005

ABSTRACTAims  To extend previous work showing lightheadedness from and liking for smoking to be associated with continued smoking while controlling for demographics and social influences that can also contribute to progression to established smoking.Design and setting  Random digit dialing telephone survey conduced on 3383 never smokers, non‐smokers, former smokers and current smokers in the continental United States.Measurements  Demographic information (sex, race, age, education level), smoking history, reactions to early experiences with smoking (lightheadedness, liking), whether parents, siblings or friends smoked when respondent was a teenager,Findings  Lightheadedness and liking interacted—those who liked smoking (regardless of lightheadedness) were very likely to progress to established smoking, while non‐likers who experienced lightheadedness were more likely than non‐likers who did not experience lightheadedness to progress. These results held even after adjusting for demographic (sex, age, race, education) and social influences (parents, siblings and friends smoking).Conclusions  Lightheadedness from early smoking appears to be associated with having smoked 100 cigarettes only among those who report not liking early smoking. Overall, this study supports the literature suggesting that early experiences, particularly liking smoking, are associated with becoming a regular smoker.
G‐banding and molecular cytogenetic analyses of marginal zone lymphoma
Authors: Aamot Hege Vangstein , Micci Francesca , Holte Harald , Delabie Jan , Heim Sverre 
Published: August 2005

SummaryWe analysed the acquired chromosomal aberrations of 22 marginal zone lymphoma (MZL) patients by various genome‐wide cytogenetic techniques, such as G‐banding, multicolour fluorescence in situ hybridisation (M‐FISH), cross‐species colour banding (RxFISH), and comparative genomic hybridisation (CGH), as well as FISH with locus‐specific probes. Patients with an abnormal chromosome 3 (n = 11), the most frequently rearranged chromosome, showed a shorter median survival than patients with a normal chromosome 3 (n = 11, 74 months vs. 219 months, P < 0·03). Four of five patients with nodal MZL had chromosome 3 abnormalities and patients with nodal MZL had a shorter median survival than patients in the other morphological subgroups of MZL (P < 0·003). CGH analysis showed only gains of chromosome material, namely of chromosome regions 3p12–25, 3q12–21, 3q23–28, 12q13–15, 12q22–24, 19p13 and 19q13 in two to four cases each (20–40%). In two MZL, the novel unbalanced translocation der(13)t(3;13)(q24;p11) was detected as the sole karyotypic rearrangement, indicating that gain of 3q24‐qter could be an important event in the pathogenesis of these lymphomas. Another two cases showed, in addition to other abnormalities, a t(4;14)(p13;q32). Both these lymphomas had involvement of the IGH gene at 14q32, and one of them also of the RHOH/TTF gene at 4p13, which encodes a new member of the RHO protein subfamily.