bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektivitas Penggunaan E-Commerce Sebagai Strategi Berwirausaha Pedagang Kaki Lima Di Jombang
Authors: Atmojo Cahyo Tri 
Published: November 2023

Penelitian ini bertujuan untuk menjelaskan secara detail tingkat efektifitas penggunaan e-commerce sebagai strategi pengembangan pedagang kaki lima di jombang kota. Penelitian ini menggunakan pendekatan deskriptif dengan pendekatan kualitatif (deskriptif dan menggunakan analisis). Penelitian dilakukan di Daerah jombang kota dengan melibatkan 3 pedagang kaki lima yang menggunakan aplikasi e-commerce didaerah sekitar jombang kota. Teknik pengumpulan data pada penelitian ini menggunakan teknik survey dengan memberikan beberapa pertanyaan terkait masalah-masalah yang dialami oleh para pedagang kaki lima..
Sumber data kami peroleh melalui wawancara baik itu secara daring maupun langsung. Adapun teknik analisis data yang kami gunakan dalam penelitian ini adalahdata sekunderberupa hasil-hasil penelitian dari berbagai artikel, juga sumber pustaka dan dokumen serta kalimat penjabaran dari berbagai jawaban subjek penelitian yang dilakukan dengan wawancara narasumber. Hasil penelitian ini menunjukkan bahwa. Penggunaan e-commerce sebagai strategi pengembangan pedagang kaki lima berpengaruh besar terhadap tingkat penjualan.
Neisseria meningitidis accumulate in large organs during meningococcal sepsis
Authors: Brusletto Berit Sletbakk , Hellerud Bernt Christian , Øvstebø Reidun , Brandtzaeg Petter 
Published: November 2023

BackgroundNeisseria meningitidis (Nm) is the cause of epidemic meningitis and fulminant meningococcal septicemia. The clinical presentations and outcome of meningococcal septic shock is closely related to the circulating levels of lipopolysaccharides (LPS) and of Neisseria meningitidis DNA (Nm DNA). We have previously explored the distribution of Nm DNA in tissues from large organs of patients dying of meningococcal septic shock and in a porcine meningococcal septic shock model.Objective1) To explore the feasibility of measuring LPS levels in tissues from the large organs in patients with meningococcal septic shock and in a porcine meningococcal septic shock model. 2) To evaluate the extent of contamination of non-specific LPS during the preparation of tissue samples.Patients and methodsPlasma, serum, and fresh frozen (FF) tissue samples from the large organs of three patients with lethal meningococcal septic shock and two patients with lethal pneumococcal disease. Samples from a porcine meningococcal septic shock model were included. Frozen tissue samples were thawed, homogenized, and prepared for quantification of LPS by Pyrochrome® Limulus Amoebocyte Lysate (LAL) assay.ResultsN. meningitidis DNA and LPS was detected in FF tissue samples from large organs in all patients with meningococcal septic shock. The lungs are the organs with the highest LPS and Nm DNA concentration followed by the heart in two of the three meningococcal shock patients. Nm DNA was not detected in any plasma or tissue sample from patients with lethal pneumococcal infection. LPS was detected at a low level in all FF tissues from the two patients with lethal pneumococcal disease. The experimental porcine meningococcal septic shock model indicates that also in porcinis the highest LPS and Nm DNA concentration are detected in lungs tissue samples. The quantification analysis showed that the highest concentration of both Nm DNA and LPS are in the organs and not in the circulation of patients with lethal meningococcal septic shock. This was also shown in the experimental porcine meningococcal septic shock model.ConclusionOur results suggest that LPS can be quantified in mammalian tissues by using the LAL assay.
Real-world practices of hormone monitoring during ovarian stimulation in assisted reproductive technology: a global online survey
Authors: Sachs-Guedj Noemie , Hart Roger , Requena Antonio , Vergara Vanessa , Polyzos Nikolaos P. 
Published: November 2023

ObjectiveThe aim of this study is to understand the global practice of routine hormonal monitoring (HM) during ovarian stimulation (OS) in the context of assisted reproductive technique (ART) treatment.MethodsAn open-access questionnaire was available to 3,845 members of IVF-Worldwide.com from September 8 to October 13, 2021. The survey comprised 25 multiple-choice questions on when and how ultrasound (US) and hormone tests were conducted during ovarian stimulation OS. For most questions, respondents were required to select a single option. Some questions allowed the selection of multiple options.ResultsIn all, 528 (13.7%) members from 88 countries responded to the questionnaire. Most respondents (98.9%) reported using US to monitor OS cycles. HM was used by 79.5% of respondents during any of the cycle monitoring visits and was most commonly performed on the day of, or a day prior to final oocyte maturation. Overall, 87% of respondents claimed adjusting the dose of gonadotropin during OS, with 61.7% adjusting the dose based on hormonal levels. Oestradiol (E2) was the most frequently monitored hormone during all visits and was used by 74% of respondents for the prediction of ovarian hyperstimulation syndrome (OHSS). On or a day prior to ovulation triggering (OT), the number of respondents who measured progesterone increased from 34.3% in the second/third visit to 67.7%. Approximately one-third of respondents measured luteinizing hormone during all visits.ConclusionGlobally, most ART specialists (~80%) use HM, along with US, for monitoring OS, especially for the prevention of OHSS.
Effects of stellate ganglion block on perimenopausal hot flashes: a randomized controlled trial
Authors: Li Ying , Chang Jia , Shi Gaoxiang , Zhang Wenjing , Wang Hui , Wei Lingyun , Liu Xiaochun , Zhang Weiwei 
Published: November 2023

BackgroundHot flashes are common symptoms afflicting perimenopausal women. A stellate ganglion block (SGB) is believed to be an effective treatment for hot flashes; however, more evidence is needed to evaluate its safety and efficacy in relieving perimenopausal hot flashes.ObjectiveTo investigate the efficacy and safety of SGB for the treatment of perimenopausal hot flashes.MethodsA randomized controlled trial was conducted at Shanxi Bethune Hospital. Forty perimenopausal women with hot flashes were recruited from April 2022 to November 2022 and randomly assigned to receive either 6 consecutive SGB treatments or 6 consecutive saline placebo treatments. The primary outcome was the change in hot flash symptom score from baseline to 12 weeks after treatment. The secondary outcomes were the change in hot flash symptom score from baseline to 12 weeks after treatment and the post-treatment Kupperman Index (KI) and Pittsburgh Sleep Quality Index (PSQI) scores.ResultsOf the 40 randomized subjects, 35 completed the study. All the variables were significantly improved. During 12 weeks of follow-up, the hot flash scores, Kupperman Menopause Scale scores, and Pittsburgh Sleep Quality Scale scores decreased significantly. Two subjects in the SGB treatment group experienced transient hoarseness, and the incidence of related adverse events was 10%. No related adverse events occurred in the control group.ConclusionCompared to the control treatment, SGB treatment was a safe and effective nonhormone replacement therapy that significantly relieved perimenopausal hot flashes and effectively improved sleep quality. Additional studies are needed to assess the long-term efficacy of this therapy.
Acquisition of complement fixing antibodies targeting Plasmodium falciparum merozoites in infants and their mothers in Uganda
Authors: Mortazavi Susanne E. , Lugaajju Allan , Nylander Maria , Danielsson Lena , Tijani Muyideen Kolapo , Beeson James G. , Persson Kristina E. M. 
Published: November 2023

BackgroundAntibody-mediated complement fixation has previously been associated with protection against malaria in naturally acquired immunity. However, the process of early-life development of complement-fixing antibodies in infants, both in comparison to their respective mothers and to other immune parameters, remains less clear.ResultsWe measured complement-fixing antibodies in newborns and their mothers in a malaria endemic area over 5 years follow-up and found that infants’ complement-fixing antibody levels were highest at birth, decreased until six months, then increased progressively until they were similar to birth at five years. Infants with high levels at birth experienced a faster decay of complement-fixing antibodies but showed similar levels to the low response group of newborns thereafter. No difference was observed in antibody levels between infant cord blood and mothers at delivery. The same result was found when categorized into high and low response groups, indicating placental transfer of antibodies. Complement-fixing antibodies were positively correlated with total schizont-specific IgG and IgM levels in mothers and infants at several time points. At nine months, complement-fixing antibodies were negatively correlated with total B cell frequency and osteopontin concentrations in the infants, while positively correlated with atypical memory B cells and P. falciparum-positive atypical memory B cells.ConclusionThis study indicates that complement-fixing antibodies against P. falciparum merozoites are produced in the mothers and placentally-transferred, and they are acquired in infants over time during the first years of life. Understanding early life immune responses is crucial for developing a functional, long lasting malaria vaccine.
Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a multi-center study
Authors: Sun Yu , Jou Eric , Nguyen Thanh N. , Mofatteh Mohammad , Liang Qingjia , Abdalkader Mohamad , Yan Zile , Feng Mingzhu , Li Xinyuan , Li Guilan , Luo Lanzhu , Lai Yuzheng , Yang Shuiquan , Zhou Sijie , Xu Zhiming , Cai Xiaodong , Chen Yimin 
Published: November 2023

Background and objectivesEndovascular thrombectomy (EVT) improves long-term outcomes and decreases mortality in ischemic stroke patients. However, a significant proportion of patients do not benefit from EVT recanalization, a phenomenon known as futile recanalization or reperfusion without functional independence (RFI). In this study, we aim to identify the major stroke risk factors and patient characteristics associated with RFI.MethodsThis is a retrospective cohort study of 297 consecutive patients with ischemic stroke who received EVT at three academic stroke centers in China from March 2019 to March 2022. Patient age, sex, modified Rankin Scale (mRS), National Institute of Health Stroke Scale (NIHSS), Alberta stroke program early CT score (ASPECTS), time to treatment, risk factors and comorbidities associated with cerebrovascular diseases were collected, and potential associations with futile recanalization were assessed. RFI was successful reperfusion defined as modified thrombolysis in cerebral infarction (mTICI) ≥ 2b without functional independence at 90 days (mRS ≥ 3).ResultsOf the 297 initial patients assessed, 231 were included in the final analyses after the application of the inclusion and exclusion criteria. Patients were divided by those who had RFI (n = 124) versus no RFI (n = 107). Older age (OR 1.041, 95% CI 1.004 to 1.073; p = 0.010), chronic kidney disease (OR 4.399, 0.904–21.412; p = 0.067), and higher 24-h NIHSS (OR 1.284, 1.201–1.373; p &lt; 0.001) were independent predictors of RFI. Conversely, an mTICI score of 3 was associated with a reduced likelihood of RFI (OR 0.402, 0.178–0.909; p = 0.029).ConclusionIn conclusion, increased age, higher 24-h NIHSS and lack of an mTICI score of 3 were independently associated with RFI and have potential prognostic values in predicting patients that are less likely to respond to EVT recanalization therapy.
Building nonenhanced CT based radiomics model in discriminating arteriovenous malformation related hematomas from hypertensive intracerebral hematomas
Authors: Xie Huanhuan , Dong Fei , Zhang Ruiting , Yu Xinfeng , Xu Peng , Tang Yinshan , Huang Peiyu , Wang Chao 
Published: November 2023

ObjectiveTo develop and validate radiomics models on non-enhanced CT for discrimination of arteriovenous malformation (AVM) related hematomas from hypertensive intracerebral hematomas.Materials and methodsA total of 571 patients with acute intraparenchymal hematomas and baseline non-enhanced CT scans were retrospectively analyzed, including 297 cases of AVM related hematomas and 274 cases of hypertensive intracerebral hematomas. The patients were divided into training and validation cohorts in a 7:3 ratio with a random seed. A total of 1,688 radiomics features of hematomas were extracted from non-enhanced CT. Then, the least absolute shrinkage and selection operator (LASSO) regression was applied to select features and construct the radiomics models. In this study, a radiomics-based model was constructed that based on the radiomics features only. Furthermore, a combined model was constructed using radiomics features, clinical characteristics and radiological signs by radiologists’ evaluation. In addition, we compared predictive performance of the two models for discrimination of AVM related hematomas from hypertensive intracerebral hematomas.ResultsA total of 67 radiomics features were selected to establish radiomics signature via LASSO regression. The radiomics-based model was constructed with 2 classifiers, support vector machine (SVM) and logistic regression (LR). AUCs of the radiomics-based model in the training set were 0.894 and 0.904, in validation set were 0.774 and 0.782 in SVM classifier and LR classifier, respectively. AUCs of the combined model (combined with radiomics, age and calcification) in the training set were 0.976 and 0.981, in validation set were 0.896 and 0.907 in SVM classifier and LR classifier, respectively. The combined model showed greater AUCs than radiomics-based model in both training set and validation set.ConclusionThe combined model using radiomics, age and calcification showed a satisfactory predictive performance for discrimination of AVM related hematomas from hypertensive intracerebral hematomas and hold great potential for personalized clinical decision.
Freezing of gait in Parkinson’s disease with glucocerebrosidase mutations: prevalence, clinical correlates and effect on quality of life
Authors: Ou Ruwei , Li Chunyu , Wei Qianqian , Liu Kuncheng , Lin Junyu , Yang Tianmi , Xiao Yi , Jiang Qirui , Cheng Yangfan , Hou Yanbing , Zhang Lingyu , Song Wei , Chen Xueping , Lai Xiaohui , Shang Huifang 
Published: November 2023

ObjectivesMutations in glucocerebrosidase (GBA1) can change the clinical phenotype of Parkinson’s disease (PD). This study aimed to explore the clinical characteristics of freezing of gait (FOG) in PD patients with GBA1 mutations.MethodsA whole-exome sequencing analysis was used to identify the GBA1 mutations (pathogenic or likely pathogenic) and exclude other PD-related gene mutations. A forward binary logistic regression model was conducted to identify the associated factors of FOG. The stepwise multiple linear regression analysis models were used to explore the effect of FOG on quality of life.ResultsThe prevalence of FOG in patients with GBA1 mutations (30/95, 31.6%) was significantly higher than those in patients without GBA1 mutations (152/760, 20%) (p = 0.009). A higher (i.e., worse) Unified PD Rating Scale part III score (OR = 1.126, 95%CI = 1.061–1.194, p &lt; 0.001) and a lower (i.e., worse) Montreal Cognitive Assessment score (OR = 0.830, 95%CI = 0.713–0.967, p = 0.017) were significantly associated with FOG in PD patients with GBA1 mutations. The presence of FOG was significantly associated with the decreased (i.e., worse) score of PD Questionnaire 39 after adjustment for sex, age, disease duration, motor score, and non-motor score (B = 14.981, p = 0.001).ConclusionFOG is a relatively common disabling symptom in PD patients with GBA1 mutations, which is affected by motor disability and cognitive decline. Quality of life is reduced in patients with FOG and GBA1 mutations.
The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease—results from a prospective cohort in China
Authors: Huang Xin , Ouyang Wenbin , Hu Yang , Tang Bei , He Yongmei , Wu Hao , Yang Pingting , Yin Lu , Liu Qingqi , Chen Kui , Deng Jing , Li Xiaohui , Li Ying 
Published: November 2023

BackgroundThe impact of weight loss and/or improved metabolic status on the risk of non-alcoholic fatty liver disease (NAFLD) has yet to be determined.MethodsA total of 35,322 participants without NAFLD were followed. NAFLD risk was compared between consistently metabolically healthy non-obese (MHNO) and non-MHNO who lost weight to become non-obese and/or improved their metabolic health, using Cox proportional hazards and logistic regression models.ResultsFollowing 148,186 person-years, 8,409 participants had onset NAFLD, with an incidence rate of 56.75 (95% CI: 55.57, 57.94) per 1,000 person-years. Metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), and metabolically unhealthy non-obese (MUNO) at baseline were associated with increased NAFLD risk, with hazard ratios of 4.48 (95%CI:4.24, 4.73), 8.85 (95%CI:7.95, 9.84), and 10.70 (95%CI:9.73, 11.78). Weight loss and/or metabolic status improvements could significantly reduce NAFLD risk by 79.46 to 41.46%. Specifically, after weight loss from MHO to MHNO, the reduction in NAFLD risk [OR decreased from 12.01 (95%CI:9.40, 15.35) to 4.14 (95%CI:3.08, 5.57)] was greater than that of the MUNO subgroup whose metabolic status improved to MHNO [OR decreased from 5.53 (95%CI:5.15, 5.94) to 2.71 (95%CI:2.50, 3.93)]. In the MUO subgroup, the group with the greatest risk reduction of NAFLD was the weight and metabolic state both improvement group [MUO to MHNO, OR decreased from 22.74 (95%CI:17.61, 29.37) to 4.67 (95%CI:3.05, 7.16)], followed by the weight loss only group [MUO to MUNO, OR decreased to 6.83 (95%CI:4.87, 9.57)], and finally the group with the least and insignificant risk reduction was the metabolic state improvement group [MUO to MHO, OR decreased to 13.38 (95%CI:9.17,19.53)]. NAFLD risk was negatively correlated with the duration of improvement (p &lt; 0.001).ConclusionIndividuals with non-MHNO were more likely to develop NAFLD than those with consistent MHNO, but metabolic improvements and weight loss can alleviate the risk. Their NAFLD risk was negatively correlated with improvement duration. However, it remained higher than in individuals with consistent MHNO at an average follow-up of 4.2 years.
Heterogeneity matching and IDH prediction in adult-type diffuse gliomas: a DKI-based habitat analysis
Authors: Liu Yanhao , Wang Peng , Wang Shaoyu , Zhang Huapeng , Song Yang , Yan Xu , Gao Yang 
Published: November 2023

ObjectiveTo explain adult-type diffuse gliomas heterogeneity through diffusion kurtosis imaging-based habitat characteristics and develop and validate a comprehensive model for predicting isocitrate dehydrogenase (IDH) status.Materials and methodsIn this prospective secondary analysis, 103 participants (mean age, 52 years; range, 21-77; 54 [52%] male) pathologically diagnosed with adult-type diffuse gliomas were enrolled between June 2018 and February 2022. The Otsu method was used to generate habitat maps with mean diffusivity (MD) and mean kurtosis (MK) for a total of 4 subhabitats containing 16 habitat features. Habitat heatmaps were created based on the Pearson correlation coefficient. The Habitat imAging aNd clinicraD INtegrated prEdiction SyStem (HANDINESS) was created by combining clinical features, conventional MRI morphological features, and habitat image features. ROC, calibration curve, and decision curve analyses were used to select the optimal model after 32 pipelines for model training and validation.ResultsIn the restricted diffusion and high-density subhabitat, MK was highly correlated with MD (R2 = 0.999), volume (0.608) and percentage of volume (0.663), and this region had the highest MK value (P&lt;.001). The unrestricted diffusion and low-density subhabitat had the highest MD value (P&lt;.001). When MK was less than the Otsu threshold, there was still a difference between restricted diffusion and low-density and unrestricted diffusion and low-density subhabitats (P&lt;.01). The HANDINESS enabled more accurate prediction of the IDH status in the training (AUC=0.951 [0.902-0.987]) and internal validation cohorts (0.938 [0.881-0.949]). AUC values for single-modality models and independent factors ranged from 0.593 to 0.916. Calibration and decision curve analyses showed that the HANDINESS demonstrated a high level of clinical applicability and predictive consistency.ConclusionDiffusion kurtosis imaging-based habitat analysis provides additional important information on microscopic tumor spatial heterogeneity. The HANDINESS has higher diagnostic performance and robustness than single-modality models.
Identifying modifiable factors associated with COVID-19 vaccine hesitancy and acceptance among cancer patients in Jordan
Authors: AlMasri Rama , Al Masri Mahmoud , Darwish Rula , Ammar Khawla , Safi Yasmin 
Published: November 2023

IntroductionVaccines stand amongst the most effective medical interventions for the management of infectious diseases, and are pivotal tools for public health. The acceptance of vaccines is heavily influenced by perceptions of efficacy, safety and other modifiable factors.PurposeThis cross-sectional study sought to identify and examine the modifiable factors that can help address COVID-19 vaccine hesitancy and acceptance among cancer patients.MethodsThe study was conducted between February and April 2021 using an online survey questionnaire comprising of four domains. The survey was administered to cancer patients in Jordan.ResultsAmong the 1,029 cancer patients who completed the online questionnaire (response rate= 73%), 58% (n=597) expressed willingness (intent) to take the vaccine. Notably, 72.5% (n=433) of those intending to take the vaccine were currently undergoing treatment. Knowledge and awareness played a significant role, with 54.3% considering them essential for vaccine acceptance. Fear of infection significantly influenced vaccine acceptance (p&lt;0.001), with 66.8% expressing concern about potential infections. Peer encouragement was also a crucial factor, as 82.4% regarded it as an important driver for influencing vaccine acceptance (p&lt;0.001).ConclusionPeer encouragement, awareness, and fear emerged as the primary modifiable factors associated with greater vaccine acceptance by patients with active malignancies. Study results suggest that providing personalized and tailored information about vaccinations, focusing on safety and potential interactions with cancer and its treatment, are potentially excellent strategies for improving vaccine acceptance among cancer patients.