bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smurfness‐based two‐phase model of ageing helps deconvolve the ageing transcriptional signature
Authors: Zane Flaminia , Bouzid Hayet , Sosa Marmol Sofia , Brazane Mira , Besse Savandara , Molina Julia Lisa , Cansell Céline , Aprahamian Fanny , Durand Sylvère , Ayache Jessica , Antoniewski Christophe , Todd Nicolas , Carré Clément , Rera Michael 
Published: October 2023

AbstractAgeing is characterised at the molecular level by six transcriptional ‘hallmarks of ageing’, that are commonly described as progressively affected as time passes. By contrast, the ‘Smurf’ assay separates high‐and‐constant‐mortality risk individuals from healthy, zero‐mortality risk individuals, based on increased intestinal permeability. Performing whole body total RNA sequencing, we found that Smurfness distinguishes transcriptional changes associated with chronological age from those associated with biological age. We show that transcriptional heterogeneity increases with chronological age in non‐Smurf individuals preceding the other five hallmarks of ageing that are specifically associated with the Smurf state. Using this approach, we also devise targeted pro‐longevity genetic interventions delaying entry in the Smurf state. We anticipate that increased attention to the evolutionary conserved Smurf phenotype will bring about significant advances in our understanding of the mechanisms of ageing.
The role of cardiac resident macrophage in cardiac aging
Authors: Li Jiayu , Xin Yanguo , Wang Zhaojia , Li Jingye , Li Weiping , Li Hongwei 
Published: October 2023

AbstractAdvancements in longevity research have provided insights into the impact of cardiac aging on the structural and functional aspects of the heart. Notable changes include the gradual remodeling of the myocardium, the occurrence of left ventricular hypertrophy, and the decline in both systolic and diastolic functions. Macrophages, a type of immune cell, play a pivotal role in innate immunity by serving as vigilant agents against pathogens, facilitating wound healing, and orchestrating the development of targeted acquired immune responses. Distinct subsets of macrophages are present within the cardiac tissue and demonstrate varied functions in response to myocardial injury. The differentiation of cardiac macrophages according to their developmental origin has proven to be a valuable strategy in identifying reparative macrophage populations, which originate from embryonic cells and reside within the tissue, as well as inflammatory macrophages, which are derived from monocytes and recruited to the heart. These subsets of macrophages possess unique characteristics and perform distinct functions. This review aims to summarize the current understanding of the roles and phenotypes of cardiac macrophages in various conditions, including the steady state, aging, and other pathological conditions. Additionally, it will highlight areas that require further investigation to expand our knowledge in this field.
Self‐sacrifice or empty symbolism: A study of $1 CEOs
Authors: Dharmasiri Prabashi , Garg Mukesh , Ng Anthony , Supardi Supardi 
Published: October 2023

AbstractWe examine whether CEOs' voluntary acceptance of a $1 salary is a credible signal of sacrifice. We find that firms with $1 salary CEOs are: (i) more likely to be associated with income‐increasing accrual‐based earnings management; (ii) less likely to use real earnings management; and (iii) more likely to engage in corporate tax avoidance. Our results indicate that this performance enhancement is driven by the motivation to restore salaries to their original levels. Our results suggest that extreme salary sacrifice could indicate an empty promise to improve firm performance and should be considered cautiously by investors and regulators.
The moderating effect of resting heart rate variability on the relationship between internet addiction tendency and brain morphology
Authors: Zeng Yuandong , Wu Guo‐Rong , Xue Yingying , Baeken Chris , Wei Luqing 
Published: October 2023

AbstractPrevious neuroimaging studies have investigated brain morphology associated with internet addiction tendency (IAT) in healthy subjects. However, whether resting vagally‐mediated heart rate variability (HRV) exerting influences on the association of IAT and brain morphology remains unclear. This study used voxel‐based morphometry (VBM) and multiple regression analyses to assess the interaction effect of IAT and resting vagally‐mediated HRV on regional grey matter volumes in 82 healthy subjects. To further illustrate the observed interaction effect, the moderated hierarchical regression analysis was performed. The results showed that resting vagally‐mediated HRV moderated the relationship between IAT scores and grey matter volume (GMV) in the precuneus and cerebellum. Specifically, individuals with higher resting vagally‐mediated HRV showed a significant positive relationship between IAT scores and GMV in the precuneus, whereas individuals with lower resting vagally‐mediated HRV showed a significant negative relationship between IAT scores and GMV in the precuneus. In addition, IAT scores were negatively correlated with GMV in the cerebellum among individuals with lower resting vagally‐mediated HRV, but not among individuals with higher resting vagally‐mediated HRV. These findings have demonstrated a moderating role of resting vagally‐mediated HRV on the association of IAT and brain morphology.
Drug overdose risk with benzodiazepine treatment in young adults: Comparative analysis in privately and publicly insured individuals
Authors: Bushnell Greta A. , Rynn Moira A. , Gerhard Tobias , Keyes Katherine M. , Hasin Deborah S. , Cerdá Magdalena , Nyandege Abner , Olfson Mark 
Published: October 2023

AbstractBackground and AimsBenzodiazepines (BZDs) carry a risk for drug overdose and are prescribed alone or simultaneously with selective‐serotonin reuptake inhibitors (SSRIs) for the treatment of anxiety and depression in young adults. We aimed to measure risks of drug overdose following BZD treatment initiation, and simultaneous BZD and SSRI initiation, compared with SSRI treatment alone in young adults with depression or anxiety.Design, Setting, ParticipantsThe cohort study used administrative databases covering privately (MarketScan, 1/1/2009–12/31/2018) and publicly (Medicaid, 1/1/2015–12/31/2016) insured young adults (18–29 years) in the United States. Those with depression or anxiety diagnoses newly initiating BZD or SSRI treatment (without BZD or SSRI prescriptions in prior year) were included. Simultaneous “BZD + SSRI” initiation was defined as starting BZD and SSRI treatment on the same day. The cohorts included 604 664 privately insured young adults (BZD = 22%, BZD + SSRI = 10%, SSRI = 68%) and 110 493 publicly insured young adults (BZD = 23%, BZD + SSRI = 5%, SSRI = 72%).MeasurementsIncident medically treated drug overdose events were identified from emergency department and inpatient encounters (ICD poisoning codes) within 6 months of treatment initiation. Crude and propensity‐score adjusted cumulative incidence and hazard ratios (HR) were estimated. Sub‐analyses evaluated drug overdose intent.FindingsAdjusted HRs of drug overdose for BZD vs. SSRI treatment was 1.36 (95% confidence interval [CI]:1.23–1.51) in privately and 1.59 (95%CI:1.37–1.83) in publicly insured young adults. The adjusted HRs of drug overdose for BZD + SSRI treatment vs. SSRI treatment were 1.99 (95%CI:1.77–2.25) in privately and 1.98 (95%CI:1.47–2.68) in publicly insured young adults.ConclusionsAmong young adults in the United States, initiating benzodiazepine treatment for anxiety and depression, alone or simultaneously with selective‐serotonin reuptake inhibitors (SSRI), appears to have an increased risk of medically treated drug overdose compared with SSRI treatment alone. These associations were observed in publicly and privately insured individuals.
The effect of silver nanoparticles in addition to sodium fluoride on remineralization of artificial root dentin caries
Authors: Kongyodsueb P , Poolthong S , Chumprasert S , Sae‐ear P , Tantilertanant Y 
Published: October 2023

AbstractBackgroundSilver nanoparticle was developed to overcome the drawback of silver diamine fluoride. However, evidence is limited, especially in root caries. The aim of this study was to evaluate the remineralization effect of silver nanoparticles on root caries.Materials and MethodsFifty‐five root human dentin slices size 5 × 5 mm2 from patients aged over 60 years old were immersed in demineralized solution to create artificial caries. Specimens were allocated into five groups according to the remineralizing agents: silver diamine fluoride (SDF), silver nanoparticles solution (AgNPs), silver nanoparticle solution followed by sodium fluoride varnish (AgNPs+NaF), sodium fluoride varnish (NaF), and tap water. After 8 days of pH‐cycling challenge, the microhardness test, lesion depth evaluation, dentin surface morphology, and elemental analysis were performed. Data was analysed using F‐test One‐way ANOVA followed by Tukey's post hoc test and paired T‐test.ResultsAll test groups demonstrated a significantly higher microhardness value and lower lesion depth compared with the control group. AgNPs+NaF and NaF‐treated groups showed lower efficacy than SDF. Crystal precipitation was presented in all groups composed of silver.ConclusionAddition of fluoride varnish did not benefit for silver nanoparticles in preventing further demineralization. SDF provides the highest effectiveness in elderly root carious dentin.
Differential expression of epithelial and smooth muscle lineage‐specific markers of metanephros in one‐humped camel foetuses
Authors: Farouk Sameh M. , Basha Walaa A. A. , Emam Mahmoud A. , Metwally Elsayed 
Published: October 2023

AbstractThe development of the metanephros in one‐humped camels involves a complex series of interactions between epithelial and mesenchymal cells. As a result, there is a synchronized differentiation process of stromal, vascular and epithelial cell types during glomerulogenesis, angiogenesis and tubulogenesis. In the current work, the metanephros of camel foetuses were divided into four stages where kidneys from each stage were processed and immunoassayed, followed by quantitative analysis to determine target protein intensities throughout metanephrogenesis in the camel. This study demonstrated robust expression of α‐smooth muscle actin (α‐SMA) in the glomerular mesangium, as well as in interlobular and glomerular arterioles during the earlier stages of development. However, in the late stages, α‐SMA expression became more localized around the blood capillaries in both the cortex and medulla. Strong expression of CD34 was observed in the immature glomerular and peritubular endothelial cells within the subcapsular zone, as well as in the glomerular, proximal tubular and distal tubular epithelium of stage one foetuses, although its expression gradually diminished with foetal maturation. The expression pattern of osteopontin was prominently observed in the distal convoluted tubules throughout all stages, however, no expression was detected in the proximal tubules, glomeruli and arterioles. E‐cadherin was detected in the developing renal tubular epithelial cells but not in the glomeruli. In conclusion, this study reveals the spatiotemporal distribution of key proteins, including α‐SMA, CD34, Osteopontin and E‐cadherin, which play a crucial role in metanephrogenesis in camel foetuses.
Recurrent reactive infectious mucocutaneous eruption (RIME) secondary to Chlamydophila pneumoniae infection in an adult
Authors: Carballido‐Vázquez Ana M. , Volo Víctor , Vega‐López Teresa L. , Santamarina‐Albertos Alba S. , Garabito‐Solovera Esther L. , Martínez‐García Gerardo , Manchado‐López Pilar 
Published: October 2023

AbstractThe terminology surrounding the clinical syndrome characterized by acute mucositis with minimal skin involvement has been a subject of debate over time. In recent years, terms such as mycoplasma‐induced rash and mucositis and reactive infectious mucocutaneous eruption (RIME) have been introduced to encompass milder mucocutaneous diseases associated with respiratory infections, with implications for management and prognosis. We report the first case of recurrent RIME associated with Chlamydophila pneumoniae infection in an adult patient. RIME is likely underreported due to misclassification and a lack of testing for potential pathogens. Early recognition of recurrent RIME is of particular interest from the patient's perspective to reduce the frequency and duration of hospital admissions.
The optimized development of China's service industry in the “Belt and Road” regional value chain: A social network analysis
Authors: Zhang Hanmei 
Published: October 2023

AbstractThe optimized development of service industry in the value chain can inject strong impetus into economic growth. The “Belt and Road” initiative provides a new path for China's service industry. This article combines value‐added accounting method and social network analysis method to study the network environment of service trade in the “Belt and Road” region and the individual characteristics of China's service trade. At the same time, the article deeply analyzes the factors that affect the optimized development of China's service industry in the “Belt and Road” regional value chain from the perspective of trade relations and puts forward countermeasures and suggestions accordingly. The study found that the “Belt and Road” regional service trade network has high density and shows a trend of blockization. As a core node in the regional service trade network, China has strong subjective initiative, connecting link, and independence in trade relations. Moreover, the optimization of China's service trade relations can further enhance its position in the “Belt and Road” regional value chain. At the same time, it can also enhance political and cultural identity, enhance China's discourse power, and promote the process of regional economic integration. Therefore, China's service industry can use the “Belt and Road” initiative to innovate the trade relationship model and realize the optimal development.
Myeloid‐derived suppressor cells as a potential biomarker for recurrent pregnancy loss and recurrent implantation failure
Authors: Subhi‐Issa Nabil , Fuente‐Muñoz Eduardo de la , Gil‐Laborda Raquel , Villegas Ángela , Alonso‐Arenilla Bárbara , Cristóbal Ignacio , Pilar‐Suárez Lydia , Jiménez‐Huete Adolfo , Calvo Marta , Sarria Beatriz , Mansilla‐Ruiz Mariló , Ochoa Juliana , Fernández‐Arquero Miguel , Sánchez‐Ramón Silvia 
Published: October 2023

AbstractProblemRecurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) represent distinct clinical conditions with established definitions, both of which have been linked to an underlying pro‐inflammatory state. This study aimed to explore the levels of monocytic‐myeloid‐derived suppressor cells (M‐MDSCs) and regulatory T cells (TReg) in a cohort of RPL and RIF women and their potential contribution to RPL and RIF.Method of studyOne hundred and eight non‐pregnant women were evaluated: 40 RPL, 41 RIF, and 27 fertile healthy controls (HC). A multiparametric flow cytometry approach was utilized to measure and quantify the frequency of M‐MDSCs and TReg cells. Cytokine levels in plasma samples were evaluated through a multiplex assay. M‐MDSCs levels were significantly higher in RPL and RIF patients compared to HC.ResultsM‐MDSCs levels were significantly higher in RPL (9.4% [7–11.6]) and RIF (8.1% [5.9–11.6]) patients compared to HC (6% [4.2–7.6]). An optimal cut‐off of 6.1% for M‐MDSCs disclosed a sensitivity of 75.6% and 89.7% and a specificity of 57.7% and 57.7% in RIF and RPL groups, respectively. A significant negative correlation was observed between M‐MDSCs and TReg (p = .002, r = −.51).ConclusionsOur preliminary data allowed us to build a predictive model that may aid as a potential diagnostic tool in the clinic. These findings could provide a better understanding of these pathologies and a better definition of patients that could benefit from personalized treatments to promote pregnancy. Additional exploration and confirmation in distinct study groups are needed to fully assess the diagnostic capabilities of this biomarker.
Comparisons of distributions of Australian mental health scores
Authors: Gunawan D. , Griffiths William E. , Chotikapanich D. 
Published: October 2023

SummaryBayesian non‐parametric estimates of Australian distributions of mental health scores are obtained to assess how the mental health status of the population has changed over time, and to compare the mental health status of female/male and Aboriginal/non‐Aboriginal population subgroups. First‐order and second‐order stochastic dominance are used to compare distributions, with results presented in terms of the posterior probability of dominance and the posterior probability of no dominance. If a criterion for dominance is satisfied, then, in terms of that criterion, the mental health status of the dominant population is superior to that of the dominated population. If neither distribution is dominant, then the mental health status of neither population is superior in the same sense. Our results suggest mental health has deteriorated in recent years, that males' mental health status is better than that of females, and that non‐Aboriginal health status is better than that of the Aboriginal population.
Care and the academy: Navigating fieldwork, funding and care responsibilities
Authors: Cox Rosie , Hope Jessica , Jenkins Katy , Ray Charlotte 
Published: October 2023

AbstractThis commentary reflects on research jointly conducted by the Development Geographies Research Group (DevGRG) and the Gender and Feminist Geographies Research Group (GFGRG) of the RGS‐IBG, which aimed to understand the challenges faced by academics with care responsibilities. We set out the effects of research funding policies and practices on researchers' ability to combine careers as academic geographers with care responsibilities, highlighting the specific effects in a field‐based subject such as Geography. We gathered data about a range of research funders' policies and how these are implemented (in various ways) in UK Geography departments. We also surveyed all UK university Geography departments to understand experiences of parental and adoption leave, including support from employers, impacts on career progression, and recommendations for support. Our data show that there is a need for a more consistent and comprehensive approach to recognising the costs of academics' caring responsibilities, to support their career progression and to mitigate the impacts disproportionately experienced by women. Funders and higher education institutes (HEIs) need to work collaboratively to develop policies and practices to address the individualised way in which (predominantly female) academics currently experience navigating the provision of funding for parental leave, and for covering costs of care during fieldwork. Our research highlights the need for consistent and progressive policies in relation to care and parental leave across all funding bodies – that can subsequently be embedded into institutional frameworks – in order to provide equity and consistency for staff across the UK higher education (HE) sector. We also emphasise the need for these policies to be more visible and transparent, making the task of navigating them more manageable for staff at an often uncertain time in their working lives.
The political foundation of mainstream media trust in East and Southeast Asia: A cross‐national analysis
Authors: Chang Alex Chuan‐hsien , Tang Yen‐Chen 
Published: October 2023

AbstractDeclining levels of trust in the media in Western democracies have drawn the attention of political scientists, but much less attention has been paid to East Asia. This paper sets out to examine the logic behind media trust in three different types of regimes in East and Southeast Asia: countries with, partial, and no press freedom, respectively. Our findings show that while respondents' trust in government and support for socioideological control of the government have consistent and significant associations with their media trust across all 12 countries, Internet usage, online political participation, support for media censorship, and patriotic belief have different associations with the variable being studied as the degree of press freedom varies. The findings indicate that citizens are well aware of the role mass media plays in the political system and thus their trust in the media reflects the expectation‐perception gap of the government‐media relationship accordingly.
Voter's gratification in using online news and the implications on political landscape in Malaysia
Authors: Alivi Mumtaz Aini 
Published: October 2023

AbstractIn recent years, democratic societies have relied heavily on online news to enlighten the public on current issues in politics. This study investigates voters' gratification in using online news and its implication on the political landscape. This study examined how information seeking, social utility, guidance/judgment, and personal fulfillment drawn from the Uses and Gratification theory, change Malaysians' voting decisions. The survey included a sample of 700 registered voters from the Malaysian Klang Valley. The data were gathered using convenience and purposive sampling using nonprobability sampling technique. Analysis from Partial Least Squares Structural Equation Modeling using SmartPLS 3.0 demonstrated that information seeking, social utility, guidance, and personal fulfillment could positively determine the people's vote choice. Using online news for guidance is the strongest predictor of the people's vote choice. This study provides important implications where the government can capitalize on the effectiveness of online media to reach the public and rationalize major policy decisions. Future research may utilize a longitudinal approach.
Corporate power and democracy: A business ethical reflection and research agenda
Authors: Kroll Christian Martin , Edinger‐Schons Laura Marie 
Published: October 2023

AbstractCorporations significantly influence the public and political spheres. In light of this corporate power in society, academics have criticized the lack of legitimization (i.e., the legitimacy gap) and highlighted a potential divergence between corporate resource allocation and the needs and preferences of the public (i.e., the social issues gap). To address these problems, democratizing organizations has been proposed as a potential solution. In line with this, the authors argue that an increase in corporate power outside the economic realm should be counterbalanced by more democratic corporate governance (i.e., an internalization of democracy). While important groundwork exists, academic attention to these topics remains limited. The authors provide an overview of the literature linking corporate power and the claim for democratizing organizations, advocate for legitimization, identify research gaps, and develop a research agenda to inspire and guide future research efforts. The paper's findings suggest the importance of conceptual and empirical research on the micro‐, meso‐, and macro‐levels and the cross‐level effects, which is needed to advance this incipient research area. Future research must (1) clearly define corporate power and discuss how democratizing organizations can contribute to more legitimate organizational decisions, (2) unveil novel approaches for more democratic corporate governance, and (3) understand the organizational‐ and individual‐level factors necessary for the successful realization of democratic organizations.