bluuebunny/crossref_metadata_2025_split huggingface dataset:
Romancing the past: Heritage visiting and the nostalgic consumer
Authors: Goulding Christina 
Published: August 2002

AbstractOver the past decade, there has been growing interest in nostalgia and consumption experiences on the part of a small group of consumer researchers. This article offers an insight into the nostalgic experiences gained through consuming history at a contemporary British “living” museum. The findings of the research focus on two types of nostalgic behavior, which are identified as existential and aesthetic. Differences in the nostalgic reaction are conceptualized in relation to such factors as the quantity and quality of the individual's role repertoire, the experience of alienation in the present, and the extent and quality of social contact. The article aims to offer a perspective that draws upon both existing work in related fields and the findings of the research in order to contextualize nostalgia as an experiential factor behind the consumption of recreated history in the living interactive museum. © 2001 John Wiley & Sons, Inc.
Calcium hydroxyapatite promotes mitogenesis and matrix metalloproteinase expression in human breast cancer cell lines
Authors: Morgan Maria P. , Cooke Michelle M. , Christopherson Pamela A. , Westfall Pamela R. , McCarthy Geraldine M. 
Published: August 2002

AbstractRadiographic mammary microcalcifications are one of the most pertinent diagnostic markers of breast cancer. Breast tissue calcification in the form of calcium hydroxyapatite (HA) is strongly associated with malignant disease. We tested the hypothesis that calcium HA may exert biological effects on surrounding cells, thereby facilitating breast cancer progression. Our findings showed that HA crystals enhanced mitogenesis in breast cancer cell lines MCF‐7 and Hs578T and also in normal human mammary epithelial cells. HA crystals were also found to upregulate the production of a variety of matrix metalloproteinases (MMPs), including MMP‐2, ‐9, and ‐13 in MCF‐7 and MMP‐9 in human mammary epithelial cell lines. HA crystals were found to greatly augment prostaglandin E2 levels in Hs578T cells, and treatment with a cyclooxygenase inhibitor, aspirin, abrogated the HA‐induced mitogenesis. These results suggest that calcium HA crystals may play an active role in amplifying the pathological process involved in breast cancer. © 2001 Wiley‐Liss, Inc.
Procedural learning and striatofrontal dysfunction in Parkinson's disease
Authors: Sarazin Marie , Deweer Bernard , Merkl Angela , Von Poser Natalia , Pillon Bernard , Dubois Bruno 
Published: August 2002

AbstractThe neural basis of procedural learning remains controversial. We further analyzed procedural learning in nondemented patients with Parkinson's disease (PD) according to the specific demands of the tasks and the severity of striatal and frontal lobe dysfunction. In the first experiment, the performance of 20 nondemented PD patients and matched normal control subjects was studied in two procedural learning tasks, rotor pursuit and mirror reading, that differ in terms of motor and cognitive involvement. A second experiment further assessed the relationship between learning in mirror reading and executive functions in a new group of 15 nondemented PD patients. In rotor pursuit, PD patients significantly progressed across the first sessions, although their asymptotic performance was inferior to that of controls. In mirror reading, both experiments showed substantial learning in PD patients considered as a group. However, subsequent analyses allowed us to distinguish PD patients without executive dysfunction, whose learning was normal, from PD patients with executive dysfunction, whose learning was severely impaired. These results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task. © 2002 Movement Disorder Society.
Early postural adjustments associated with gait initiation and age‐related walking difficulties
Authors: Patchay Sandhiran , Gahéry Yves , Serratrice Georges 
Published: August 2002

AbstractTo better understand the functional role of early postural adjustments associated with gait initiation, we studied ground reaction forces before the first step in a group of 10 young and 18 elderly normal subjects as well as in a group of 11 patients with marche à petits pas, an age‐related gait disorder in which difficulties in executing the first step are encountered. Kinematic data and ground reaction forces were recorded synchronously and processed by an ELITE motion analysis system. Start difficulties in the patients might be explained by impaired amplitudes and directions of anteroposterior forces as well as smaller values of vertical forces than in the controls walking with comparable step lengths. Indeed, the abnormalities of anteroposterior forces lead to defective propulsive forces, whereas the smaller upward reaction forces make the elevation of the starting leg more difficult. These perturbations are likely to reflect impairments of muscular synergies of the lower limbs manifested by disturbances in the agonist–antagonist coupling, and lack of coordination between both limbs. © 2002 Movement Disorder Society
Bilateral striopallidodentate calcinosis: Clinical characteristics of patients seen in a registry
Authors: Manyam Bala V. , Walters Arthur S. , Narla Koteswara R. 
Published: August 2002

AbstractClinical features in bilateral striopallidodentate calcinosis (BSPDC), popularly referred to as Fahr's disease (five autosomal dominant families and eight sporadic cases, n = 38), recruited through a registry, are reported. Applying uniform criteria, cases reported in the literature (n = 61) were combined for detailed analysis. The mean (± S.D.) age of Registry patients was 43 ± 21 and that of literature was 38 ± 17. In combined data set (n = 99), 67 were symptomatic and 32 were asymptomatic. Of the symptomatic, the incidence among men was higher compared with women (45:22). Movement disorders accounted for 55% of the total symptomatic patients. Of the movement disorders, parkinsonism accounted for 57%, chorea 19%, tremor 8%, dystonia 8%, athetosis 5%, and orofacial dyskinesia 3%. Overlap of signs referable to different areas of central nervous system (CNS) was common. Other neurologic manifestations included: cognitive impairment, cerebellar signs, speech disorder, pyramidal signs, psychiatric features, gait disorders, sensory changes, and pain. We measured the total volume of calcification using an Electronic Planimeter and Coordinate Digitizer. Results suggest a significantly greater amount of calcification in symptomatic patients compared to asymptomatic patients. This study suggests that movement disorders are the most common manifestations of BSPDC, and among movement disorders, parkinsonism outnumber others. © 2001 Movement Disorder Society.
Somatosensory disinhibition in dystonia
Authors: Frasson Emma , Priori Alberto , Bertolasi Laura , Mauguière Francois , Fiaschi Antonio , Tinazzi Michele 
Published: August 2002

AbstractDespite the fact that somatosensory processing is inherently dependent on inhibitory functions, only excitatory aspects of the somatosensory feedback have so far been assessed in dystonic patients. We studied the recovery functions of spinal N13, brainstem P14, parietal N20, P27, and frontal N30 somatosensory evoked potentials (SEPs) after paired median nerve stimulation in 10 patients with dystonia and in 10 normal subjects. The recovery functions were assessed (conditioning stimulus: S1; test stimulus: S2) at interstimuls intervals (ISIs) of 5, 20, and 40 ms. SEPs evoked by S2 were calculated by subtracting the SEPs of the S1 only response from the SEPs of the response to the paired stimuli (S1 + S2), and their amplitudes were compared with those of the control response (S1) at each ISI considered. This ratio, (S2/S1)*100, investigates changes in the excitability of the somatosensory system. No significant difference was found in SEP amplitudes for single stimulus (S1) between dystonic patients and normal subjects. The (S2/S1)*100 ratio at the ISI of 5 ms did not significantly differ between dystonic patients and normal subjects, but at ISIs of 20 and 40 ms, this ratio was significantly higher in patients than in normals for spinal N13 and cortical N20, P27, N30 SEPs.These findings suggest that in dystonia there is an impaired inhibition at spinal and cortical levels of the somatosensory system which would lead to an abnormal sensory assistance to the ongoing motor programs, ultimately resulting in the motor abnormalities present in this disease. © 2001 Movement Disorder Society.
Jules Bernard Luys and the subthalamic nucleus
Authors: Parent André 
Published: August 2002

AbstractJules Bernard Luys, a highly energetic French investigator who made important contributions to anatomopathology, clinical neurology, and psychiatry, discovered the subthalamic nucleus in 1865. Unfortunately, Luys’ description of the nucleus that still bears his name, as well as his highly original insights on the role of this important motor structure, are rarely taken into account in the current thinking about the basal ganglia organization. Thus, we thought it of interest to review Luys’ contribution to our knowledge of the subthalamic nucleus and also briefly examine the other remarkable achievements of this singular figure of 19th century neurology. © 2001 Movement Disorder Society.
Design of clinically useful iron(III)‐selective chelators
Authors: Liu Zu D. , Hider Robert C. 
Published: August 2002

AbstractIron overload is a serious clinical condition which can be largely prevented by the use of iron‐specific chelating agents. Desferrioxamine‐B, the most widely used iron chelator in haematology over the past 30 years, has a major disadvantage of being orally inactive. Consequently, the successful design of an orally active, nontoxic, selective iron chelator has become a much sought after goal. In order to identify an ideal iron chelator for clinical use, a range of specifications must be considered such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity. A wide range of chelator types bind iron(III) and of these, hexa‐, tri‐, and bidentate are capable of providing iron(III) with the favoured octahedral environment. In this review, the comparative properties of such ligands are discussed, examples being selected from hydroxamates, aminocarboxylates, hydroxypyridinones, orthosubstituted phenols and triazoles. © 2001 John Wiley & Sons, Inc. Med Res Rev, 22, No. 1, 26–64, 2002
Development of the blood‐nerve barrier in neonatal rats
Authors: Smith Christopher E. , Atchabahian Arthur , Mackinnon Susan E. , Hunter Daniel A. 
Published: August 2002

AbstractThe blood‐nerve barrier (BNB) is constituted by the perineurium and the endothelium of endoneurial microvessels. We investigated the age at which the vascular component of BNB function is established in the rat and the ultrastructural modifications accompanying changes in permeability. BNB permeability was assessed with injections of Evans blue albumin (EBA) and horseradish peroxidase (HRP) in rats of different ages. Sciatic nerve sections were studied using fluorescence and electron microscopy. Nerves from animals injected with EBA indicated that the BNB is not functional before 13 days of life but that its function is established by 16 days. These results were confirmed by electron microscope examination of nerve sections from animals injected with HRP, which showed clefts between the endothelial cells of endoneurial vessels in young rats. In rats over 18 days, these clefts were occluded by tight junctions, which prevented HRP from leaving the vessel lumen and conferred BNB function. Systematic morphometric analysis of nerves from different age groups allowed the establishment of baseline normal histologic neural development with age. © 2001 Wiley‐Liss, Inc. MICROSURGERY 21:290–297 2001
Secondary surgery after digit replantation: Its incidence and sequence
Authors: Wang Huan 
Published: August 2002

AbstractThis article discusses the incidence and sequence of secondary procedures following digital replantation. In published series addressing this topic, the overall frequency of postreplantation surgery ranged from 2.9–93.2%. Tendon procedures accounted for 47.2% of cases, and comprised the leading type of secondary operations. Tendon procedures were followed by joint procedures (18.9%), skeletal stabilization (12%), skin coverage (11.4%), nerve reconstruction (8.9%), and late amputation (1.6%). The number of secondary procedures per patient averaged from 1–4.5, depending on prioritization of different procedures. The order of restoration procedures should be as follows: supple skin coverage, skeletal stability, and protective and proprioceptive sensation. Joint reconstruction follows these procedures, which in turn is followed by tendon reconstruction. © 2002 Wiley‐Liss, Inc. MICROSURGERY 22:57–61 2002
Effect of hyperbaric oxygen on pedicle flaps with compromised circulation
Authors: Ülkür Ersin , Yüksel Fuat , Açikel Cengiz , Çeliköz Bahattin 
Published: August 2002

AbstractThe effect of hyperbaric oxygen (HBO) on the survival rate of experimental rat pedicle island flaps with arterial, venous, and combined arteriovenous insufficiency was evaluated. Forty male Wistar rats with pedicle island flaps were divided into four groups with different types of vascular status. Another 40 male Wistar rats, also divided into four groups, were reconstructed in the same manner, but were also exposed to HBO. The results were evaluated using a laser Doppler flowmeter and an estimation of the length of the surviving tissue of the flaps. In evaluations using Kruskal–Wallis test, there was a significant difference in the survival tissue length and mean LD flows among our four untreated groups (P < 0.05). We considered the experimental model defined by Tzusuki and colleagues suitable for our study. Using a Mann‐Whitney test, the differences in flap tissue survival length between each type of vascular insufficiency of HBO‐treated and untreated groups was significant (P < 0.05). This finding indicates that the survival length was directly improved by the HBO treatment for all type of vascular insufficiency. HBO treatment increased the percentage of survival length and mean LD flows of axial pattern skin flaps with all type of vascular insufficiency. This effect, however, was greatest in the arterial insufficiency flaps. © 2002 John Wiley & Sons, Inc. MICROSURGERY 22:16–20, 2002 DOI 10.1002/micr.22004
Simulation, fabrication, and characterization of 3‐D alumina photonic bandgap structures
Authors: Chen Y. , Bartzos D. , Lu Y. , Niver E. , Pilleux M. E. , Allahverdi M. , Danforth S. C. , Safari A. 
Published: August 2002

AbstractThree‐dimensional photonic bandgap (PBG) structures using alumina as the high‐permittivity material were designed and then fabricated by using the fused deposition of multimaterials (FDMM) process. The finite‐element and real‐time electromagnetic modeling ofthe fabricated structure resulted in a 3‐D photonic bandgap in the16–24 GHz range, which agreed with experimental measurements. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 30: 305–307, 2001.
Pattern and course of single‐system disease in Langerhans cell histiocytosis data from the DAL‐HX 83‐ and 90‐study
Authors: Titgemeyer Carola , Grois Nicole , Minkov Milen , Flucher‐Wolfram Burgi , Gatterer‐Menz Irmgard , Gadner Helmut 
Published: August 2002

AbstractBackgroundSingle‐system (SS) disease is the most common presentation in Langerhans cell histiocytosis (LCH) with a heterogenous clinical picture and course. Mostly bone and rarely skin or lymph nodes are involved.ProcedureOne hundred and seventy patients with SS‐LCH were registered in the DAL‐HX 83/90 studies. They were diagnosed according to uniform diagnostic criteria and followed by a standardised schedule.ResultsSingle bone lesions were most common (68%), followed by multiple bone lesions (19%), isolated skin disease (11%), and isolated lymph node involvement (4 patients). In the detection of bone lesions radiographic skeletal survey proved to be superior to bone scan (97% vs. 82%). Treatment comprised surgery, irradiation and local instillation of steroids, and standardised chemotherapy for multifocal bone disease. After initial therapy 81% of the patients remained disease free. Reactivations restricted to the skeleton occurred in 18% of both unifocal and multifocal bone disease. Two skin patients had a chronic course. Fatality occured only in one infant with skin disease who progressed to multi‐system disease. Twenty‐five percent of all patients developed permanent consequences, which were already present at diagnosis in about half of these patients and comprised mainly orthopedic problems related to lesional sites. Diabetes insipidus occurred in 3% and anterior pituitary dysfunction in 2% of the patients.ConclusionsThe course in SS%LCH was benign. In bone disease reactivations remained restricted to the skeleton and did not influence survival. However, reactivations had an impact on morbidity, as permanent consequences were mostly related to the site of disease activity. Med Pediatr Oncol 2001;37:108–114. © 2001 Wiley‐Liss, Inc.
Differential distribution of glutamylated tubulin isoforms along the sea urchin sperm axoneme
Authors: Huitorel Philippe , White Daniel , Fouquet Jean‐Pierre , Kann Marie‐Louise , Cosson Jacky , Gagnon Claude 
Published: August 2002

AbstractTubulin belongs to a highly conserved multigenic family, in which several gene products usually coexist in the same tissue or the same cell. Moreover, seven classes of post‐translational modifications of these gene products lead to an amazing diversity of tubulin polypeptide chains, within the same cell type, whose physiological function remains elusive. Such diversity has been found in a very stable microtubular organelle, the sea urchin sperm flagellum, where some tubulin isoforms have been directly implicated in motility, whereas others may play a more structural role. In particular, polyglutamylated tubulin has been shown to be crucial for motility (Gagnon et al., 1996: J Cell Sci 109:1545 p). Here, we show with the GT335 antibody that polyglutamylated tubulin is distributed according to a decreasing gradient along the sea urchin sperm axoneme, since a semi‐quantitative measurement of immunofluorescence intensity reveals that in its proximal half, the axoneme is sixfold more labeled than in its distal half. This gradient along the length of the axoneme is confirmed by immunogold labeling procedures which, in addition, demonstrate a uniform distribution of polyglutamylated tubulin among peripheral doublets and a lesser content in the central pair within a same section. Moreover, our data obtained with B3, an antibody that recognizes both mono‐ and poly‐glutamylated tubulin, suggest that the number of glutamate residues in the lateral poly‐glutamyl chain of tubulin varies along the whole length of the axoneme. These novel results coupled with those published earlier may be important to understand the role of polyglutamylation in flagellar motility. Mol. Reprod. Dev. 62: 139‐148, 2002. © 2002 Wiley‐Liss, Inc.
Primordial germ cell‐somatic cell partnership: A balancing cell signaling act
Authors: Kierszenbaum Abraham L. , Tres Laura L. 
Published: August 2002

AbstractRecent studies demonstrate that the normal progression of the germ cell lineage during gonadogenesis involves a delicate balance of primordial germ cell survival and death factors generated by surrounding somatic cells. This balance operates in a different fashion in females and males. The fine tuning primordial germ cell specification in the wall of the yolk sac, migration through the hindgut and dorsal mesentery, and colonization in the urogenital ridges involves the temporal and spatial activation of the following signaling pathways: Primordial germ cell specification involves bone morphogenetic proteins 2, 4 and 8b, and their migration is facilitated by the c‐kit receptor‐ligand duet. When colonization occurs: (1) neuregulin‐β ligand is expressed and binds to an ErbB2–ErbB3 receptor tyrosine kinase heterodimer on primordial germ cells; (2) Vasa, an ortholog of the Drosophila gene vasa, member of an ATP‐dependent RNA helicase of the DEAD (Asp‐Glu‐Ala‐Asp)‐box family protein is also expressed by primordial germ cells; (3) Bcl‐x (cell survival factor) and Bax (cell death factor) join forces to modulate the first burst of primordial germ cell apoptosis; (4) Cadherins, integrins, and disintegrins bring together primordial germ cells and somatic cells to organize testis and ovary. Information on other inducers of primordial cell survival, such as TER (teratoma) factor, is beginning to emerge. Mol. Reprod. Dev. 60: 277–280, 2001. © 2001 Wiley‐Liss, Inc.
Glucose transporter expression is developmentally regulated in in vitro derived bovine preimplantation embryos
Authors: Augustin Robert , Pocar Paola , Navarrete‐Santos Anne , Wrenzycki Christine , Gandolfi Fulvio , Niemann Heiner , Fischer Bernd 
Published: August 2002

AbstractGlucose is readily been taken up and utilized by preimplantation embryos from different species. However, a comprehensive analysis of the glucose transporter expression throughout preimplantation development is still missing. Here, we have investigated the expression of facilitative glucose transporters (Glut1–5 and 8) and sodium‐dependent‐glucose transporter (SGLT‐I) in bovine oocytes and preimplantation embryos up to d16 of development, using RT‐PCR and immunohistochemistry. The embryos were produced in vitro by IVM–IVF. Glut1, Glut3, Glut8, and SGLT‐I were expressed in all stages studied. Glut4 transcripts were first detected at the blastocyst stage. Glut2 expression was restricted to the period of blastocyst elongation at d14 and d16. Transcription of the fructose transporter Glut5 started at the 8‐/16‐cell stage. Our results show a distinct expression pattern for glucose transporters during bovine embryo development in vitro indicating specialized functions for these isoforms at different developmental stages in bovine embryos. Mol. Reprod. Dev. 60:370‐376, © 2001 Wiley‐Liss, Inc.
Novel growth factor supporting survival of murine primordial germ cells: evidence from conditioned medium of ter fetal gonadal somatic cells
Authors: Takabayashi Shuji , Sasaoka Yumiko , Yamashita Masayo , Tokumoto Toshinobu , Ishikawa Katsutoshi , Noguchi Motoko 
Published: August 2002

AbstractThe ter (teratoma, chromosome 18) mutation causes a deficiency of primordial germ cells (PGCs) in ter/ter embryos from the ter congenic mouse strain at 8.0 days post coitum (dpc). In order to analyse the function of the ter gene, here we examined effects of conditioned medium (CM) from 14.5 dpc testicular and ovarian somatic cells of +/+, +/ter, or ter/ter genotype on mouse PGCs “mixed‐cultured” with own somatic cells on feeder cells. The results showed that +/+ and +/ter CM supported survival in 9.5 and 11.5 dpc ICR PGCs but ter/ter CM did not rescue TUNEL (terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labeling)‐positive apoptosis in the PGCs though it did not affect 5‐bromo‐2‐deoxyuridine incorporation in PGCs. This supportive substance in +/+ CM, not ter/ter CM, was characterized as soluble, heat labile, and larger than 30 kDa. We also found that several known growth factors for PGCs and their receptors were expressed in ter/ter testes as well as +/+ testes, suggesting the ter function is independent. Thus, it was concluded that fetal gonadal somatic cells express a novel PGC growth factor (designated as TER Factor) supporting survival of PGCs not somatic cells and that the PGC deficiency in ter/ter testes is caused by a loss of this factor. Mol. Reprod. Dev. 60:384‐396, © 2001 Wiley‐Liss, Inc.