bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-psychotic Outcomes in Young People at Ultra-High Risk of Developing a Psychotic Disorder: A Long-Term Follow-up Study
Authors: Spiteri-Staines Anneliese E , Yung Alison R , Lin Ashleigh , Hartmann Jessica A , Amminger Paul , McGorry Patrick D , Thompson Andrew , Wood Stephen J , Nelson Barnaby 
Published: February 2024

Abstract

Background
The majority of individuals at ultra-high risk (UHR) for psychosis do not transition to a full threshold psychotic disorder. It is therefore important to understand their longer-term clinical and functional outcomes, particularly given the high prevalence of comorbid mental disorders in this population at baseline.

Aims
This study investigated the prevalence of non-psychotic disorders in the UHR population at entry and long-term follow-up and their association with functional outcomes. Persistence of UHR status was also investigated.

Study design
The sample comprised 102 UHR young people from the Personal Assessment and Crisis Evaluation (PACE) Clinic who had not transitioned to psychosis by long-term follow-up (mean = 8.8 years, range = 6.8–12.1 years since baseline).

Results
Eighty-eight percent of participants at baseline were diagnosed with at least one mental disorder, the majority of which were mood disorders (78%), anxiety disorders (35%), and substance use disorders (SUDs) (18%). This pattern of disorder prevalence continued at follow-up, though prevalence was reduced, with 52% not meeting criteria for current non-psychotic mental disorder. However, 35% of participants developed a new non-psychotic mental disorder by follow-up. Presence of a continuous non-psychotic mental disorder was associated with poorer functional outcomes at follow-up. 28% of participants still met UHR criteria at follow-up.

Conclusions
The study adds to the evidence base that a substantial proportion of UHR individuals who do not transition to psychosis experience persistent attenuated psychotic symptoms and persistent and incident non-psychotic disorders over the long term. Long-term treatment and re-entry into services is indicated.
Textualism as a Theory of Interpretation of Legal Norms in the Context of Doctrinal Views
Authors: Serediuk Vitalii , Shutak Illya , Onyshchuk Ihor 
Published: February 2024

Abstract
The relevance of the study is due to the problem of establishing the accuracy of the content of legal norms. Accordingly, there is a need to define a new way to explain, apply, and understand them. The purpose of the article is to carry out a theoretical and legal analysis of textualism as a theory of interpretation of legal norms. The research used such methods as analysis, deduction, induction, comparative analysis, and others. Taking the research through the prism of the doctrine of textualism in the interpretation of legal norms, the authors demonstrated that the effectiveness of this method is capable of restoring the semantic content of the text, which helps to clarify the meaning of the norms effectively and consistently. They found that the method under study could be applicable in legal practice to disclose the construction of legal norms, which multiply chances to provide accurate disclosure of the legal content of the norm. The practical value of the results lies in the identification of a new way of interpreting the norms, which will provide a future opportunity to increase the level of effective law enforcement of the current legislation.
Judicial Review Challenges to Secondary Legislation in England and Wales: Courting Controversy
Authors: Mills Alistair 
Published: February 2024

Abstract
The importance of secondary legislation in England and Wales cannot be understated. Its significance dwarfs the amount of political scrutiny which it receives. Secondary legislation can be subject to judicial review, but this may raise difficult constitutional issues. A potentially controversial ground of judicial review is that secondary legislation is contrary to the purposes of the enacting primary legislation. Examination of litigation regarding legal aid regulations shows how the courts’ view as to the purposes of such legislation can differ, revealing the essentially political choices which the courts have to make. There is however a way that will assist the courts in limiting such controversy if they find secondary legislation to be unlawful: they can order that the secondary legislation be quashed only from a future date, which would give Parliament or the executive time to address the legal defect identified. This encourages dialogue rather than conflict between the legal and executive branches of the constitution.
Black Women as Superwomen? The Mental Health Effects of Superwoman Schema, Socioeconomic Status, and Financial Strain
Authors: Erving Christy L , McKinnon Izraelle I , Thomas Tobin Courtney S , Van Dyke Miriam E , Murden Raphiel , Moore Reneé H , Booker Bianca , Vaccarino Viola , Lewis Tené T 
Published: February 2024

Abstract
Informed by Black feminist thought and intersectionality, Superwoman Schema (SWS) is a construct that captures a collective response of Black women to racial and gender marginalization by highlighting expectations that they exude strength, suppress emotions, resist vulnerability, succeed despite limitations, and help others to their own self-neglect. Using a sample of Black women (N = 390) in early-midlife (between 30 and 46 years old; M = 37.54 years; SD = 4.29), this study integrates the intersectionality framework and the stress process model to examine the independent and interactive effects of SWS endorsement as well as socioeconomic status (SES) and financial strain on Black women’s mental health. Study results reveal that SWS dimensions “emotion suppression” and “obligation to help others” are associated with elevated depressive symptoms. In addition, net worth and financial strain, but not traditional measures of socioeconomic status such as education and income, moderate the association between SWS endorsement and depressive symptoms. Specifically, the association between SWS and depressive symptoms is strongest among Black women reporting negative net worth or high financial strain (e.g., not being able to make ends meet). Broader implications and future research directions are discussed.
A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee Osteoarthritis
Authors: Matas Jose , García Cynthia , Poblete Daniela , Vernal Rolando , Ortloff Alexander , Luque-Campos Noymar , Hidalgo Yessia , Cuenca Jimena , Infante Catalina , Cadiz Maria Ignacia , Khoury Maroun , Luz-Crawford Patricia , Espinoza Francisco 
Published: February 2024

Abstract
Osteoarthritis (OA) is the most common degenerative joint disease. Mesenchymal stromal cells (MSC) are promising cell-based therapy for OA. However, there is still a need for additional randomized, dose-dependent studies to determine the optimal dose and tissue source of MSC for improved clinical outcomes. Here, we performed a dose-dependant evaluation of umbilical cord (UC)-derived MSC (Celllistem) in a murine model and in knee OA patients. For the preclinical study, a classical dose (200.000 cells) and a lower dose (50.000 cells) of Cellistem were intra-articularly injected into the mice knee joints. The results showed a dose efficacy response effect of Cellistem associated with a decreased inflammatory and degenerative response according to the Pritzker OARSI score. Following the same approach, the dose-escalation phase I clinical trial design included 3 sequential cohorts: low-dose group (2 × 106 cells), medium-dose group (20 × 106), and high-dose group (80 × 106). All the doses were safe, and no serious adverse events were reported. Nonetheless, 100% of the patients injected with the high-dose experienced injection-related swelling in the knee joint. According to WOMAC total outcomes, patients treated with all doses reported significant improvements in pain and function compared with baseline after 3 and 6 months. However, the improvements were higher in patients treated with both medium and low dose as compared to high dose. Therefore, our data demonstrate that the intra-articular injection of different doses of Cellistem is both safe and efficient, making it an interesting therapeutic alternative to treat mild and symptomatic knee OA patients.
Trial registration ClinicalTrials.gov NCT03810521.
Conditioned Medium From Stem Cells of Human Exfoliated Deciduous Teeth Alleviates Mouse Osteoarthritis by Inducing sFRP1-Expressing M2 Macrophages
Authors: Xia Linze , Kano Fumiya , Hashimoto Noboru , Liu Yao , Khurel-Ochir Tsendsuren , Ogasawara Naoko , Ding Cheng , Xu Yang , Hibi Hideharu , Iwasaki Tomonori , Tanaka Eiji , Yamamoto Akihito 
Published: February 2024

Abstract
Intravenous administration of conditioned medium from stem cells of human exfoliated deciduous teeth (SHED-CM) regenerates mechanically injured osteochondral tissues in mouse temporomandibular joint osteoarthritis (TMJOA). However, the underlying therapeutic mechanisms remain unclear. Here, we showed that SHED-CM alleviated injured TMJ by inducing anti-inflammatory M2 macrophages in the synovium. Depletion of M2 by Mannosylated Clodrosome abolished the osteochondral repair activities of SHED-CM. Administration of CM from M2-induced by SHED-CM (M2-CM) effectively ameliorated mouse TMJOA by inhibiting chondrocyte inflammation and matrix degradation while enhancing chondrocyte proliferation and matrix formation. Notably, in vitro, M2-CM directly suppressed the catabolic activities while enhancing the anabolic activities of interleukin-1β-stimulated mouse primary chondrocytes. M2-CM also inhibited receptor activator of nuclear factor NF-κB ligand-induced osteoclastogenesis in RAW264.7 cells. Secretome analysis of M2-CM and M0-CM revealed that 5 proteins related to anti-inflammation and/or osteochondrogenesis were enriched in M2-CM. Of these proteins, the Wnt signal antagonist, secreted frizzled-related protein 1 (sFRP1), was the most abundant and played an essential role in the shift to anabolic chondrocytes, suggesting that M2 ameliorated TMJOA partly through sFRP1. This study suggests that secretome from SHED exerted remarkable osteochondral regeneration activities in TMJOA through the induction of sFRP1-expressing tissue-repair M2 macrophages.
Microbial water quality investigation through flow cytometry fingerprinting: from source to tap
Authors: Claveau Leila , Hudson Neil , Jarvis Peter , Jeffrey Paul , Hassard Francis 
Published: February 2024

Abstract
Ensuring the quality of treated drinking water is crucial for preventing potential health impacts, regulatory fines, and reputation damage. Traditional culture-based microbiological methods often fail to capture the heterogeneity of the bacterial communities in drinking water. This study employed daily interstage monitoring and flow cytometry (FCM) analysis over a period of one year to investigate the dynamics of water treatment processes and service reservoirs. The objective of this study was to test the utility of FCM fingerprints for aiding in microbial event detection. We found that the chlorine concentration contact time was pivotal for microbial log reduction across the treatment works. FCM fingerprints exhibited significant deviations during operational events, such as process interruptions, but did not correlate with the presence of bacterial indicator organisms in the distributed and tap water. Furthermore, the diversity of bacterial fingerprints, quantified by the Bray–Curtis dissimilarity index, served as an indicator for identifying potentially poor microbial water quality. In chlorinated waters with low cell counts, the background signal shows potential as a metric to differentiate between different water sources, thereby offering the possibility to characterize breakthrough events in these circumstances that challenge most other microbial analytical methods. Interestingly, groundwater from simpler treatment works showed a higher occurrence of bacterial indicators, whereas surface water works had a lower incidence. These findings underpin the importance of appropriate disinfection even for “low-risk” source waters and the added value that the statistical interpretation of FCM data can offer objective decision making.
“I Was Told to Think Like a Middle-Aged White Woman”: A Survey on Identity and the Association of Social Work Boards Exam
Authors: Torres Maria Elena , Maguire Sunny , Kogan Jennie 
Published: February 2024

Abstract
The release of the 2022 Association of Social Work Boards (ASWB) exam passage rate report confirmed what many test takers who failed their exam believe. The ASWB exams are biased, with differential passage rates based on the test taker’s race, age, and “English as a second language” status. However, the report only offered basic descriptive statistics and lacked insight into the test takers’ experience. The present study addresses this gap. Results are from a 2022 survey of individuals who had taken the ASWB master’s level licensing exam (N = 1,045) highlighting test taker identity and experience. Thirty percent of the study sample identified as neurodivergent, 29.1 percent as primary caregivers, and 27.1 percent as Black, Indigenous, or persons of color. White respondents had the highest first-attempt passing rates (95.7 percent), followed by Latinx and Black respondents (84.9 percent and 78.2 percent, respectively). Forty-four respondents reported taking the test three or more times before passing. Among this group, 52 percent identified as Black, 25 percent as White, and 18 percent as Latinx. Respondents were asked how they felt their identity impacted their experience, and three interrelated themes emerged: privilege, challenges, and critique of the exam. Respondents discussed the impact of having or not having privilege; the emotional, physical, and financial challenges of preparing for the exam; and the ways in which they experienced the exam as biased.
Exploring Social Work Practitioners’ Perspectives on the Contributors to Burnout since the COVID-19 Pandemic
Authors: Childs Tasha M , Iachini Aidyn L , Reitmeier Melissa , Browne Teri , DeHart Dana , Bengel Ala , Haynesworth My’Ashia 
Published: February 2024

Abstract
Burnout has a historic and disproportionate impact on social workers and is one important contributor to the ongoing health and behavioral health workforce crisis in the United States. Little is known, however, about social workers’ experiences of burnout and their perceptions of factors that contribute to burnout since the COVID-19 pandemic. This study sought to explore this by answering the following research questions: (a) To what extent are social workers in South Carolina experiencing burnout? and (b) What do South Carolina social workers view as the top reasons for burnout in their professional role? Seventy social work practitioners and leaders from South Carolina completed an online survey during Fall 2022 that included the Copenhagen Burnout Inventory and an open-ended question focused on identifying their perceptions of the top three reasons for burnout in the profession. Findings suggest that social workers in this study are experiencing moderate levels of burnout since the COVID-19 pandemic and report primarily organizational (83 percent) contributors to burnout. They also identified individual (36 percent), systemic (29 percent), and interpersonal (27 percent) contributors to burnout. Implications are discussed related to policy and practice responses to prevent and address burnout among social workers.
Applying a Novel Approach to Understanding Social Worker Job Retention during the Pandemic
Authors: Kranke Derrick Alan , Kranke Bridget , Solorzano Emily , Gioia Debbie , Dobalian Aram 
Published: February 2024

Abstract
The job demands–resources (JD-R) theory explicates factors that facilitated social worker burnout prepandemic. Authors believe the JD-R theory can illustrate how certain factors facilitated social worker job retention in the novel context of the pandemic because a sizable group of social workers resisted burnout-related turnover. Disseminating these factors can benefit the profession. Qualitative cross-sectional data were elicited from a semistructured interview about experiences of U.S. Department of Veterans Affairs (VA) outpatient social workers (N = 13) who provided care during the pandemic. Authors conducted content analysis and coded the text into six themes of factors that facilitated retention: (1) commitment to serving veteran population, (2) job flexibility, (3) supportive colleagues, (4) leadership support, (5) maintaining normal routines, and (6) trusting in scientific/evidence-based practices. Application of the JD-R theory illustrated how social workers utilized specific resources that balanced job demands during the pandemic and facilitated job retention. Future work should apply the JD-R theory among larger samples of VA social workers, as well as non-VA social workers, in the context of the pandemic, for comparative purposes. Authors conclude with policy implications related to the impact of permanently allowing telework options and job flexibility options among social workers.
Caregiving and Obesity among Black American Adults
Authors: Ellis Katrina R , Raji Dolapo , Pennings Jacquelyn S , Thorpe Roland J , Bruce Marino A 
Published: February 2024

Abstract
Black American adults often report higher rates of obesity and caregiving compared with other racial or ethnic groups. Consequently, many Black American caregivers and care recipients are obese or have obesity-related chronic conditions (e.g., diabetes, hypertension). This study investigated associations between caregiving and obesity among Black Americans, including the role of health behaviors and chronic conditions. The sample included data from 2015 and 2017 Behavioral Risk Factor Surveillance System for non-Hispanic Black (NHB) or African American adult caregivers (n = 2,562) and noncaregivers (n = 7,027). The association between obesity (dependent variable) and caregiving status, fruit consumption, vegetable consumption, physical activity, and number of chronic conditions (independent variables) were evaluated using hierarchical binomial logistic regressions. Caregiving, being female, and chronic conditions were associated with higher odds of obesity, while physical activity was associated with lower odds of obesity. Physical activity, diet, and chronic conditions did not account for differences in obesity among caregiving and noncaregiving Black Americans. Increasing understanding of health behaviors and chronic disease burden of NHB caregivers has implications for programs aiming to improve obesity-related outcomes for caregivers and recipients. Future research should investigate multilevel factors that contribute to observed differences.
Clockor2: Inferring Global and Local Strict Molecular Clocks Using Root-to-Tip Regression
Authors: Featherstone Leo A , Rambaut Andrew , Duchene Sebastian , Wirth Wytamma 
Published: February 2024

Abstract
Molecular sequence data from rapidly evolving organisms are often sampled at different points in time. Sampling times can then be used for molecular clock calibration. The root-to-tip (RTT) regression is an essential tool to assess the degree to which the data behave in a clock-like fashion. Here, we introduce Clockor2, a client-side web application for conducting RTT regression. Clockor2 allows users to quickly fit local and global molecular clocks, thus handling the increasing complexity of genomic datasets that sample beyond the assumption of homogeneous host populations. Clockor2 is efficient, handling trees of up to the order of 104 tips, with significant speed increases compared with other RTT regression applications. Although clockor2 is written as a web application, all data processing happens on the client-side, meaning that data never leave the user’s computer. Clockor2 is freely available at https://clockor2.github.io/.
Comparative transcriptomics of the chilling stress response in two Asian mangrove species, Bruguiera gymnorhiza and Rhizophora apiculata
Authors: Short Aidan W , Sebastian John Sunoj V , Huang Jie , Wang Guannan , Dassanayake Maheshi , Finnegan Patrick M , Parker John D , Cao Kun-Fang , Wee Alison K S 
Published: February 2024

Abstract
Low temperatures largely determine the geographic limits of plant species by reducing survival and growth. Inter-specific differences in the geographic distribution of mangrove species have been associated with cold tolerance, with exclusively tropical species being highly cold-sensitive and subtropical species being relatively cold-tolerant. To identify species-specific adaptations to low temperatures, we compared the chilling stress response of two widespread Indo-West Pacific mangrove species from Rhizophoraceae with differing latitudinal range limits—Bruguiera gymnorhiza (L.) Lam. ex Savigny (subtropical range limit) and Rhizophora apiculata Blume (tropical range limit). For both species, we measured the maximum photochemical efficiency of photosystem II (Fv/Fm) as a proxy for the physiological condition of the plants and examined gene expression profiles during chilling at 15 and 5 °C. At 15 °C, B. gymnorhiza maintained a significantly higher Fv/Fm than R. apiculata. However, at 5 °C, both species displayed equivalent Fv/Fm values. Thus, species-specific differences in chilling tolerance were only found at 15 °C, and both species were sensitive to chilling at 5 °C. At 15 °C, B. gymnorhiza downregulated genes related to the light reactions of photosynthesis and upregulated a gene involved in cyclic electron flow regulation, whereas R. apiculata downregulated more RuBisCo-related genes. At 5 °C, both species repressed genes related to CO2 assimilation. The downregulation of genes related to light absorption and upregulation of genes related to cyclic electron flow regulation are photoprotective mechanisms that likely contributed to the greater photosystem II photochemical efficiency of B. gymnorhiza at 15 °C. The results of this study provide evidence that the distributional range limits and potentially the expansion rates of plant species are associated with differences in the regulation of photosynthesis and photoprotective mechanisms under low temperatures.
Single centre analysis of factors influencing surgical treatment of splenic trauma in children
Authors: Zhao Jun Gang , Hao Chen-Xiang , Xu Yong-Gen , Liu Feng , Zhu Guo-Ji 
Published: February 2024

Abstract

Objective
This study aims to investigate determinants impacting the surgical management of splenic trauma in paediatric patients by scrutinizing age distribution, etiological factors and concomitant injuries. The analysis seeks to establish a foundation for delineating optimal operative timing.

Methods
A cohort of 262 paediatric cases presenting with splenic trauma at our institution from January 2011 to December 2021 underwent categorization into either the conservative or operative group.

Results
Significantly disparate attributes between the two groups included age, time of presentation, blood pressure, haemoglobin levels, blood transfusion requirements, thermal absorption, American Association for the Surgery of Trauma (AAST) classification and associated injuries. Logistic regression analysis revealed age, haemoglobin levels, AAST classification and blood transfusion as autonomous influencers of surgical intervention (OR = 1.024, 95% CI: 1.011–1.037; OR = 1.067, 95% CI: 1.01–1.127; OR = 0.2760, 95% CI: 0.087–0.875; OR = 7.873, 95% CI: 2.442–25.382; OR = 0.016, 95% CI: 0.002–0.153). The AAST type and age demonstrated areas under the receiver operating characteristic (ROC) curve of 0.782 and 0.618, respectively.

Conclusion
Age, haemoglobin levels, AAST classification and blood transfusion independently influence the decision for surgical intervention in paediatric patients with splenic trauma. Age and AAST classification emerge as viable parameters for assessing and prognosticating the likelihood of surgical intervention in this patient cohort.