bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coastal populations experience sea level rise at least twice as large as the global average
Authors: Oelsmann Julius , Nicholls Robert , Lincke Daniel , Marcos Marta , Sánchez Laura , Dettmering Denise , Hinkel Jochen , Horton Benjamin , Seitz Florian 
Published: October 2023

Abstract
Coastal subsidence can significantly increase rates of relative sea level change over and above climate-related changes, and has been reported to be particularly large in densely populated regions. However, due to the small scale variability of vertical land motion (VLM) and the sparsity of VLM observations, there is currently still low confidence in VLM and the uncertainties this introduces in sea level change estimates. Therefore, we synergize currently available VLM observations (from GNSS, InSAR, tide gauges, and satellite altimetry) to investigate the impact of VLM on relative sea level changes and their uncertainties, as well as the implications for coastal populations. We find that the average contemporary (1995-2019) global relative sea level change experienced by coastal populations (5.14 mm/year) is more than twice as large as the average coastal relative sea level change (2.09 mm/year). This is because rates of subsidence tend to be higher in densely populated areas. A significant part of the coastline (representing 40% of the coastal population) lacks measurements or access to the direct measuring stations which are necessary to constrain VLM rates estimated with InSAR. Missing, or imprecise VLM constraints contribute to the increased population-weighted uncertainties in the relative sea level change trends of ~3 mm/year. Thus, future community efforts are needed to improve the observational database in the disproportionately exposed and densely populated coasts in order to reduce uncertainties in estimates of future relative sea-level rise and their societal implications.
Efficacy of Farsan Ventilation Equipment (FVE) on Oxygenation and End-Tidal Carbon Dioxide During Cataract Surgery under Local Sedation: A Randomized Clinical Trial
Authors: Farsani Hamidreza Azizi , Tafrishinejad Arash , Hassanpour Kiana , Farsani Zahra Azizi , Farsani Abolfazl Azizi , Karjou Zahra 
Published: October 2023

Abstract
Background:
This study aimed to investigate the efficacy of novel ventilation equipment on oxygenation and end-tidal carbon dioxide levels during cataract surgery under local anesthesia.
Methods:
A total of two hundred patients undergoing cataract surgery under local anesthesia were included in this randomized controlled trial. Patients were randomly assigned to receive local anesthesia using Farsan Ventilation Equipment (FVE) on their chest during the procedure, while the control group received oxygen through a nasal cannula (NC). The primary outcome measures were end-tidal CO2 (EtCO2) and the fraction of inspired carbon dioxide (FICO2). The secondary outcome measures included peripheral arterial O2 saturation (SpO2), the patient's respiratory rate, heart rate, and mean arterial pressure.
Results:
The mean surgery time was 35.5 ± 7.05 minutes in the NC group and 38.2 ± 6.2 minutes in the FVE group. The FVE group showed significantly lower levels of EtCO2 and FICO2 and higher SpO2 compared to the NC group during the operation. In the FVE group, SpO2 remained stable at high levels, and there was no increase in EtCO2 and FICO2 during the operation. Additionally, the FVE group exhibited significantly lower respiratory rate (RR), heart rate (HR), and mean arterial pressure (MAP) compared to the NC group.
Conclusion:
Farsan Ventilation Equipment (FVE) is easy to handle and proves helpful in preventing carbon dioxide accumulation, carbon dioxide rebreathing, unwanted tachypnea, and patient exhaustion. It is particularly beneficial for practical use in elderly patients undergoing eye surgery under local anesthesia.
Trial Registration Code: The trial is registered at https://irct.ir/ with the code IRCT20210216050379N2. Further details can be found at https://fa.irct.ir/trial/55786/pdf.
SPP1 promotes brain metastasis of NSCLC by up-regulating PI3K/AKT/mTOR pathway
Authors: Li Xiaoqin , Wu Yun , Yue Wenxiang , Lin Ming , Li Hongru , Lin Ying , Chen Yusheng 
Published: October 2023

Abstract
Purpose
Brain metastasis (BM) is a significant contributor to poor prognosis in patients with non-small cell lung cancer (NSCLC). Secreted phosphoprotein 1 (SPP1) is involved in the progression and metastasis of various cancers. However, the role of SPP1 in NSCLC, particularly in NSCLC BM, remains unclear. This study aimed to identify genes associated with NSCLC BM and investigate the involvement of SPP1 in NSCLC BM.
Methods
Integrated genomic analysis was used to identify candidate genes in NSCLC. Expression levels of SPP1 were evaluated in NSCLC tumor tissues and cell lines. In vitro and in vivo experiments were conducted to assess the impact of SPP1 on NSCLC cell behavior and BM. The underlying mechanism involving the PI3K/AKT/mTOR pathway was explored.
Results
SPP1 expression was found to be elevated in NSCLC tissues and cell lines. SPP1 depletion using shRNA inhibited cell proliferation, migration, and invasion in vitro and suppressed BM in vivo. Mechanistically, SPP1 partly influenced NSCLC progression through the PI3K/AKT/mTOR signaling pathway. Moreover, immunohistochemical staining demonstrated that SPP1 expression was higher in NSCLC tissues with BM than in those without BM. Furthermore, elevated SPP1 expression was associated with poor clinical outcomes in patients with NSCLC.
Conclusion
This study highlights the role of SPP1 as a regulator of cell metastasis and suggests its potential as a novel therapeutic target for BM in NSCLC.
STRABO AND DIODORUS ON THE PHYSICAL BARBARITY OF THE IBERIANS
Authors: КАМАРИ Д.М. 
Published: October 2023

Античные авторы неосознанно под этнонимом «иберийцы» называли разные этнические группы, которые проживали на территории Пиренейского полуострова. Эти этнические группы отличались друг от друга происхождением, традициями и уровнем культурного и социально-экономического развития. В источниках большая часть жителей этого далеко региона представлена дикими и неукротимыми. Однако жители юга Пиренейского полуострова, в отличие от населения внутренних областей, имели письменность и развитую систему торговых связей. По мнению автора, слава о дикости и варварских традициях иберийцев связана с кельтами, которые в конце VI в. до н.э. распространились по большей части Пиренейского полуострова, нападая на богатые финикийские города.
The ancient authors used the ethnonym Iberians for different ethnic groups that lived in the territory of the Iberian Peninsula. These ethnic groups differed from each other in origin, traditions and level of cultural and socio-economic development. In the sources, most of the inhabitants of this far region are wild and indomitable. However, the inhabitants of the south of the Iberian Peninsula, unlike the population of the interior, had a written language and a developed system of trade relations. According to the author, the fame of the savagery and barbarian traditions of the Iberians is associated with the Celts, who at the end of the 6th century BC spread throughout most of the Iberian Peninsula, attacking the wealthy Phoenician cities.
IMMANIS AND IMMANITAS AS APPLIED TO THE BARBARIANS IN THE USE OF CICERO
Authors: НИКИШИН В.О. 
Published: October 2023

Семантический диапазон прилагательного immanis в словоупотреблении Цицерона довольно широк — от нейтрального «огромный» до унизительного «грубый». Характерно, что эпитет immanis с уничижительно-грубым и оскорбительным подтекстом Цицерон применяет по отношению не только к варварам, но и к своим личным врагам или оппонентам из числа римлян, т.е. носителей полисной цивилизации. Таким образом, варварство в худших своих проявлениях проникло в пространство античной культуры. Можно сказать, что вербальное варварство в известном смысле породнило римлян и варваров. То же самое относится и к существительному immanitas, которое может означать множество или толпу, но чаще всего — варварство в самых неприглядных его проявлениях. Все эти негативные качества, объединённые понятием immanitas, как и в случае с эпитетом immanis, применимы к некоторым представителям античной цивилизации в не меньшей степени, чем к «природным» варварам. Так этнолингвистический характер феномена «варварство» как бы переводится Цицероном в культурно-этическую, нравственную плоскость.
The semantic range of the adjective immanis in Cicero's usage is quite wide — from the neutral «huge» to the derogatory «rude». It is characteristic that Cicero uses the epithet immanis with a derogatory, rude and insulting connotation in relation not only to barbarians, but also to his personal enemies or opponents from among the Romans, i.e. carriers of the polis civilization. Thus, barbarism in its worst manifestations penetrated into the space of ancient culture. It can be said that verbal barbarism, in a certain sense, related the Romans and the barbarians. The same applies to the noun immanitas, which can mean a multitude or a crowd, but most often — barbarism in its most unsightly manifestations. All these negative qualities, united by the concept of immanitas, as in the case of the epithet immanis, are applicable to some representatives of ancient civilization to no lesser extent than to «natural» barbarians. Thus, the ethno-linguistic nature of the phenomenon of «barbarism» is, as it were, translated by Cicero into a cultural, ethical, moral plane.
Physical restraints practice in adult intensive care units: a review
Authors: Gorbachev Vladimir I. , Bragina N. V. , Netesin E. S. , Petrova I. L. , Gorbachev S. V. 
Published: October 2023

OBJECTIVE: To describe the available evidence on indications, complications, care and alternative strategies in the use of physical restraint in adult patients in Intensive Care Units. MATERIALS AND METHODS: An integrative review conducted in the Cochrane, PubMed, Scopus, LILACS, Nursing Database and the eLibrary portal. The search was performed on the queries: “physical restriction”, “fixation devices in intensive care”, “patient safety”, “fixation of the patient”. RESULTS: The final selection was of 93 articles, from which the indications, complications, care and alternative strategies were extracted. CONCLUSIONS: The most common practices regarding physical restraints in Russia and foreign countries were described, and the need for the elaboration and implementation of protocols on intervention to support decision — making was observed.
Cyclosporine A therapy in patients with COVID-19 and failure of immunosuppression therapy: a retrospective cohort propensity-score matched analysis
Authors: Merzhoeva Z. M. , Yaroshetskiy A. I. , Savko S. A. , Krasnoshchekova A. P. , Mandel Irina A. , Tsareva N. A. , Trushenko N. V. , Nuralieva G. S. , Avdeev S. N. 
Published: October 2023

INTRODUCTION: Therapy of COVID-19 patients with progressive lung damage after the use of glucocorticosteroids (GCS) and interleukin-6 inhibitors (IIL-6) has not yet been developed. OBJECTIVE: Assessment of the effectiveness of cyclosporine A in patients with COVID-19 with progression of lung damage and hypoxemic acute respiratory failure, who received therapy with GCS and IIL-6. MATERIALS AND METHODS: A retrospective cohort propensity-score matched analysis (n = 98). Cyclosporine A was prescribed in the first 72–96 hours after IIL-6 administration when the patient's condition worsened. The patients of comparison group corresponded to the study group, but did not receive cyclosporine A therapy. The primary end point was in-hospital mortality. Secondary endpoints — duration of hospitalization, number of patients admitted to the intensive care unit (ICU), need for respiratory support. RESULTS: Mortality was 12 (22) % in the cyclosporine group and 27 (61) % in the comparison group, р = 0.001 (hazard ratio [HR] 2.00 (1.12–3.48), р = 0.018), ICU admission rate 14 (26) % vs 29 (66) %, р = 0.001, respectively. In the cyclosporine group on day 7 CT-4, there were 26 % of patients vs 52 % in the control group, р = 0.014, the need for respiratory support (37 % vs 63.6 %, р = 0.011); saturation 88 % (82–93) vs 80 % (70–86), р = 0.001, respectively. The need for respiratory support at day 11 after IIL-6 increased the likelihood of death (HR 7.10 (2.5–20), р = 0.001). Risk factors for death: age over 57.5 years, body mass index over 30 kg/m2, hemoglobin oxygen saturation below 85.5 % on the day of IIL-6 application. Duration of hospitalization was 18.5 (14–24) days vs 18 (12–24) days, р = 0.778. CONCLUSIONS: Cyclosporine A in addition to GCS and IIL-6 for COVID-19 therapy may reduce mortality, ICU admissions, and respiratory support requirements.
The ultrasound assessment of the inferior vena cava collapsibility in the prone volunteers through a new acoustic window: a prospective observational study
Authors: Kasatkin Anton A. , Matreshkin V. A. 
Published: October 2023

INTRODUCTION: Ultrasound assessment of inferior vena cava (IVC) collapsibility is used in clinical practice to assess patients' volume status. Finding the subject in the prone position limits the ability to assess IVC collapse by the traditional method, which requires the use of alternative methods. OBJECTIVE: Conducting a comparative assessment of the IVC collapse index in healthy volunteers in the back position and in the pro position using a new acoustic window. MATERIALS AND METHODS: Ultrasound observation was performed in 25 adult healthy volunteers of both sexes. Ultrasound measurement of IVC was carried out sequentially in the position of volunteers on the back and abdomen. The mean (M) and standard deviation (SD) of the maximum and minimum IVC size. The values of the collapsing index (CI) obtained during the study are presented as a median (Me) and quartiles (Q1–Q3). Wilcoxon's nonparametric test was selected for comparative analysis (significance level accepted 0.05). RESULTS: Measurements of the diameter of the inferior vena cava obtained the following results: the average maximum and minimum vein size in volunteers in the supine position were 1.58 ± 0.37 cm and 1.30 ± 0.36 cm, respectively; in prone — 1.51 ± 0.37 cm and 1.24 ± 0.36 cm, respectively. Me (Q1–Q3) IVC-CI values (%) in volunteers in the supine and in the prone position of the voice were 16.84 (8.86–24.39) and 15.63 (10.23–24.77), respectively. Statistical analysis of the obtained results did not reveal a significant difference between CI values (p = 0.861). CONCLUSIONS: The absence of a statistically significant difference in IVC-CI values in the supine and abdominal volunteers demonstrates the possibility of using a new acoustic window to assess volume status in the clinical setting in patients in the prone position.
The effect of a tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine diacetate (Dalargin) on oxidative stress in patients with severe combined trauma: a prospective clinical study
Authors: Antonova V. V. , Evseev A. K. , Goroncharovskaya I. V. , Ryzhkov A. Yu. , Grebenchikov Oleg A. , Shabanov A. K. 
Published: October 2023

INTRODUCTION: Severe combined trauma remains the leading cause of mortality and disability of the workable population. Under damaging factor influence, a whole cascade of pathological processes is triggered, leading to development of multiple organ failure. OBJECTIVE: Exploration of the effects synthetic analogue of tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine diacetate (Dalargin) on the dynamics of oxidative stress markers in patients with severe polytrauma and the development of organ dysfunction. MATERIALS AND METHODS: 104 patients with severe combined trauma were included in study. There were 38 patients in the Dalargin group and 66 patients in the control group. Patients from main group received Dalargin in the form of a constant infusion through a syringe dispenser at the dose of 10 mcg/kg/hour at first 12 hours of hospitalization and 5 mcg/kg/hour up to 72 hours from the moment of admission. The control group received standard treatment. Indicators of oxidative stress were evaluated at the time of admission (0 days), 1, 3, 5, 7, 10 and 14 days from the therapy onset. RESULTS: In the main group, there was a significant decrease in oxidative stress markers such as malondialdehyde from the first day of treatment (p < 0.05), normalization of stable nitric oxide metabolites at day 10, and a decrease in total antioxidant activity below normal throughout the observation period. Mortality was comparable in both groups (p > 0.05), but the length of hospital stay was lower in surviving patients in the Dalargin group (p < 0.05). The development of organ dysfunction (acute respiratory distress syndrome, acute kidney injury) was less frequent in the Dalargine group (p < 0.05), but infectious complications (pneumonia, meningitis, wound suppuration) were comparable. CONCLUSIONS: Dalargin leads to a decrease of oxidative stress markers and normalization of endothelial function indicators, which contributes to a decrease of organ dysfunction frequency.
Sensuality Representation Of Guinness Dark Beer Advertising
Authors: Migotuwio Namuri , Ika Indrayati Refita , Wisnu Wijaya P.G. 
Published: October 2023

This study examines the rhetorical meaning of "stout" dark beer advertising photos with the Guinness trademark presented with a sensuality approach. Roland Barthes' semiotics is used to reveal symbolic meaning in advertising. In addition, to explain the concept of secrecy and the psychological aspects implied in the advertisement elaborated using Lacan's psychoanalytic theory. Based on an in-depth analysis, it was concluded that the sensuality approach through bodily on Guinness dark beer advertising posters was considered in line with the spirit of the company that wanted to present an elegant, masculine impression and able to accommodate the cultural spirit of patriarchal society in Ireland and the world. In addition, the use of legs and the use of black are considered to be able to represent the history of the slave trade in Ireland and express the discourse of sensuality that developed in the country. Visualization with digital imaging techniques is a bridge to the ideological conflict between sensuality as a concept that is still considered taboo by society and advertising as a medium for commodification of Guinness products.
Survival of Partial Laminate Veneers and Categorical Covariates Affecting the Survival: A Systematic Review
Authors: Çötert İrem , Çötert H. Serdar 
Published: October 2023

Background:
Partial laminate veneers (PLV) have been accepted widely among both clinicians and patients with their favorable specifications, such as conservativeness, superior esthetics, bond strength and durability, for three decades. Various esthetic and functional impairments spreading in a wide range may be restored with veneers instead of full contour crowns.

Objective:
Although advantages, partial laminate veneers are not free from complications and various factors can influence the service duration of these restorations.

Methods:
An electronic Pubmed/Medline and Google Academic search was conducted without time restriction, providing information on porcelain laminate veneer’s failure rate and survival. Assessment of the identified studies was performed by two independent reviewers. Clinical service durations and various types of failures were evaluated.

Results:
Debonding, fracture, discoloration of the porcelain; staining or disintegration of tooth-porcelain margin; hypersensitivity, secondary caries, pulp necrosis and the periodontal responses were the more frequently studied failures. The mean CFR was found as 8,22% per study. Enamel substrate, incisal overlapping and lithium disilicate veneers presented lower failure rates in comparison with dentine substrate, non-overlapping and feldspathic veneers.

Conclusion:
PLV’s have high survival rates. The overall survival of PLV restorations can be affected by several prognostic variables.
The Activity of α-glucosidase Inhibition of Pediococcus Acidilactici BAMA 4 Isolated from “Naniura” Traditional Foods from North Sumatera, Indonesia
Authors: Riastawaty Dewi , Girsang Ermi , Fachrial Edy , Ginting Chrismis Novalinda , Piska Finna , Nasution Ali Napiah 
Published: October 2023

Background:
Type 2 diabetes is caused by unhealthy lifestyles, such as consuming foods rich in simple sugars and lack of exercise. One of the treatment therapies for this disease is α-glucosidase inhibitors. Some strains of the lactic acid bacteria (LAB) group typically exhibit α-glucosidase inhibitory activity, antimicrobial activity, acids and bile salt tolerance, and probiotic status.

Objective:
This study aims to isolate LAB from naniura, characterize and test its activity as an α-glucosidase inhibitor, as well as identify those with the highest activity.

Methods:
The method used to molecularly identify potentially good LAB was through the amplification of the 16S rRNA gene.

Results:
This study obtained a total of 9 strains using BAMA codes 1, 2, 3, 4, 5, 6, 7, 8, and 9. The cocci cell activity, gram-positive, and antibacterial activity of BAMA 4 against E.coli was 7.54 mm, while against S. aureus was 8.05 mm. The percentage of viability in acid and bile salt is 28.7% and 68.6%, respectively. Additionally, the proportion of α-glucosidase inhibition is 65%.

Discussion:
The BAMA 4 strain is a species of Pediococcus acidilactici. Pediococcus is a genus of gram-positive lactic acid bacteria in the Lactobacillacea family.

Conclusion:
BAMA 4 strain produced antibacterial optimally and its cells survived the growth in acid and bile conditions. The percentage of probiotics was relevantly high in this activity. This study will be helpful for other in-vivo research.
Can Gratitude Become a Religiosity Mediator on Employee Job Satisfaction?
Authors: Winarsunu Tulus , Aminuddin Riskun Karim , Djudiyah  , Anwar Zainul 
Published: October 2023

Aims:
This study aimed to determine the role of gratitude as a mediator between the influence of religiosity on employee job satisfaction

Methods:
Quantitative research design with purposive sampling technique on 40 Primagroup Indonesia employees. Data were collected using the Religiosity Scale, Minnesota Satisfaction Questionnaire, and Gratitude Scale, distributed directly to the respondents. Data analysis used Mediation Regression Analysis with the help of the SPSS version 26 program.

Results:
The test results of the direct influence of religiosity on job satisfaction were not significant (β = 0.10; p = 0.56 (p > 0.05)), meaning that hypothesis 1 was rejected. These results show that there is no direct influence of religiosity on job satisfaction when a gratitude mediator is presented. The results of the gratitude test as a mediator of the influence of religiosity on job satisfaction showed significant results (β = 0.23; p = 0.04 (p < 0.05)), which means that hypothesis 2 is accepted.

Conclusion:
The results showed that gratitude could mediate the effect of religiosity on employee job satisfaction. Gratitude can fully mediate the influence of religiosity on employee job satisfaction. So employees who have religiosity will feel more satisfied with their workers if through gratitude.