bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation in the frozen lesion size according to the non-occluded application duration and technique for cryoballoon ablation
Authors: Kawaji Tetsuma , Bao Bingyuan , Hojo Shun , Tezuka Yuji , Nakatsuma Kenji , Matsuda Shintaro , Kato Masashi , Yokomatsu Takafumi , Miki Shinji 
Published: January 2024

Objective
The frozen lesion formation created by cryoballoon ablation, especially with non-occluded applications, has not been fully evaluated. This study aimed to validate the lesion size under different cryoballoon ablation settings: application duration, push-up technique, and laminar flow.

Methods
The frozen lesion size was evaluated immediately after ending the freezing with three different application durations (120, 150, and 180 seconds) in porcine hearts (N = 24). During the application, the push-up technique was applied at 10, 20, and 30 seconds after starting the freezing with or without laminar flow.

Results
The lesion size was significantly correlated with the nadir balloon temperature (P<0.001). The lesion volume became significantly larger after 150 seconds than 120 seconds (1272mm3 versus 1709mm3, P = 0.004), but not after 150 seconds (versus 1876mm3 at 180 seconds, P = 0.29) with a comparable nadir balloon temperature. Furthermore, the lesion volume became significantly larger with the push-up technique with the largest lesion size with a 20-second push-up after the freezing (1193mm3 without the push-up technique versus 1585mm3 with a push-up at 10 seconds versus 1808mm3 with a push-up at 20 seconds versus 1714mm3 with a push-up at 30 seconds, P = 0.04). Further, the absence of laminar flow was not associated with larger lesion size despite a significantly lower nadir balloon temperature.

Conclusion
The frozen lesion size created by cryoballoon ablation became larger with longer applications at least 150 seconds and with a push-up technique especially at 20 seconds after the freezing.
West Nile virus spread in Europe: Phylogeographic pattern analysis and key drivers
Authors: Lu Lu , Zhang Feifei , Oude Munnink Bas B. , Munger Emmanuelle , Sikkema Reina S. , Pappa Styliani , Tsioka Katerina , Sinigaglia Alessandro , Dal Molin Emanuela , Shih Barbara B. , Günther Anne , Pohlmann Anne , Ziegler Ute , Beer Martin , Taylor Rachel A. , Bartumeus Frederic , Woolhouse Mark , Aarestrup Frank M. , Barzon Luisa , Papa Anna , Lycett Samantha , Koopmans Marion P. G. 
Published: January 2024

Background
West Nile virus (WNV) outbreaks in birds, humans, and livestock have occurred in multiple areas in Europe and have had a significant impact on animal and human health. The patterns of emergence and spread of WNV in Europe are very different from those in the US and understanding these are important for guiding preparedness activities.

Methods
We mapped the evolution and spread history of WNV in Europe by incorporating viral genome sequences and epidemiological data into phylodynamic models. Spatially explicit phylogeographic models were developed to explore the possible contribution of different drivers to viral dispersal direction and velocity. A “skygrid-GLM” approach was used to identify how changes in environments would predict viral genetic diversity variations over time.

Findings
Among the six lineages found in Europe, WNV-2a (a sub-lineage of WNV-2) has been predominant (accounting for 73% of all sequences obtained in Europe that have been shared in the public domain) and has spread to at least 14 countries. In the past two decades, WNV-2a has evolved into two major co-circulating clusters, both originating from Central Europe, but with distinct dynamic history and transmission patterns. WNV-2a spreads at a high dispersal velocity (88km/yr–215 km/yr) which is correlated to bird movements. Notably, amongst multiple drivers that could affect the spread of WNV, factors related to land use were found to strongly influence the spread of WNV. Specifically, the intensity of agricultural activities (defined by factors related to crops and livestock production, such as coverage of cropland, pasture, cultivated and managed vegetation, livestock density) were positively associated with both spread direction and velocity. In addition, WNV spread direction was associated with high coverage of wetlands and migratory bird flyways.

Conclusion
Our results suggest that—in addition to ecological conditions favouring bird- and mosquito- presence—agricultural land use may be a significant driver of WNV emergence and spread. Our study also identified significant gaps in data and the need to strengthen virological surveillance in countries of Central Europe from where WNV outbreaks are likely seeded. Enhanced monitoring for early detection of further dispersal could be targeted to areas with high agricultural activities and habitats of migratory birds.
Selenium protects against nesfatin‐1 modulation of the hypothalamic‐pituitary‐testicular axis during hypothyroidism in male rats
Authors: El‐Shaer Rehab Ahmed Ahmed , Ibrahim Sarah , Hewady Passant Medhat , Atef Marwa Mohamed , El‐Deeb Omnia Safwat , Hafez Yasser Mostafa , Amer Rania Saed , El‐Sharnoby Jehan Abd El‐Hameed , AbuoHashish Norhan Ahmed , Awad Marwa Mahmoud 
Published: January 2024

AbstractNormal gonadal function can be disrupted by hypothyroidism. Hypothyroidism disturbs testicular function directly and centrally by affecting the hypothalamic‐pituitary‐testicular axis with unclear mechanism. As nesfatin‐1 neurons co‐localized with TRH and GnRH neurons in the hypothalamus, it could play a role in centrally hypothyroidism induced testicular dysfunction. Selenium (Se), by affecting thyroid iodide supply, could relieve these disturbances. So, we aim to identify the role of nesfatin‐1 as a link between testicular dysfunction and hypothyroidism through modulating the MAPK/ERK pathway while discussing the possible role of Se in alleviating hypothyroidism and associated testicular damage. Forty male rats were divided equally into: Control: distilled water, Se: Se orally, Propylthiouracil (PTU): PTU orally, PTU + Se: Se with PTU orally. Serum thyroid function, gonadal hormones, nesfatin‐1, testicular redox status, sperm analysis, brain tissue GnRH, nucleobindin 2‐derived polypeptide, pMAPK/ERK gene expression, histological changes and immunohistochemical expression of testicular proliferating cell antigen (PCNA) were done. PTU induced hypothyroidism and reduction of gonadal hormones which both were correlated with reduced nesfatin‐1. There was testicular stress with reduced GnRH, NUCB2, pMAPK/ERK gene expression, and PCNA immunopositive cells. These parameters were reversed by Se. Nesfatin‐1 could be the central link between hypothyroidism and disturbances of the hypothalamic pituitary testicular axis.
Impact of biogenic zinc oxide nanoparticles on growth, development, and antioxidant system of high protein content crop (Lablab purpureus L.) sweet
Authors: Qahtan Ahmed A. , Alatar Abdulrahman A. , Salih Abdalrhaman M. 
Published: January 2024

Abstract

Lablab (Lablab purpureus L.) Sweet “white” is a vegetable crop belonging to the Fabaceae family, and it has been used in many ways as food, ornamental plant, green manure, and medicinal. In contrast, zinc oxide nanoparticles (ZnO NPs) play an important role in plant growth and development. The aim of this current study was to investigate the impact of biogenic ZnO NPs on the growth, development, and antioxidant system of L. purpureus (Sweet). Thus, different concentrations (0.0, 10, 25, 50, and 100 mg/L) of biogenic ZnO NPs were used. The seeds of Lablab were immersed into the concentrations of ZnO NPs for 24 h and cultivated in sterilized soil. Next, after 2 months of growth under greenhouse conditions, the morphological and physico-biochemical parameters were evaluated. In general, the recorded results showed that the biogenic ZnO NPs have a significant impact on germination, fresh and dry biomass of the Lablab crop. The same results were observed with photosynthetic pigments, carotenoids, total protein content, enzyme activity, and phenolic comments. Also, the accumulation of nutrients such as nitrogen and zinc in edible tissue was increased in response to the addition of ZnO NPs. Moreover, the scavenging ability of sample methanolic extract to diphenyl-2-picryl-hydrazyl, azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, and hydrogen peroxide was affected by the addition of biogenic ZnO NPs. Furthermore, the level of gene expression under ZnO NPs can be investigated for a better understanding of the process that leads to improving the growth and development of crops.
Evolution of the second phases in the weld seams of 2.25Cr-Mo-0.25 V steel in different heat treatment states
Authors: Duan Xiugang , Zhu Lin , Zhang Xinjin , Huo Jie , Ren Liguo 
Published: January 2024

Abstract
The evolution characteristics of the second phases in the weld seams of 2.25Cr-Mo-0.25 V steel in three states – welded, post-weld heat-treated and creep states – during manufacturing and service were evaluated by calculations and observations using optical microscopy, scanning electron microscopy, transmission electron microscopy and X-ray diffraction spectrometry. The results showed that the second phase was M
3C in the as-welded state. The types and quantities of the precipitated phases increased greatly after post-weld heat treatment (PWHT), and M
3C, M
2C, M
7C3, M
23C6 and MX were the main precipitated phases. During PWHT, the amount of M
7C3 decreased, the amounts of M
23C6 and MX increased, and the sizes of the second phases increased. The precipitates coarsened after long-term creep, and M
7C3, M
6C, M
23C6, M
2C, and MX were the main precipitate phases in this state. The size of the MX phase remained relatively stable during long-term creep, which contributed greatly to the creep resistance.
Numerical solutions of generalized Atangana–Baleanu time-fractional FitzHugh–Nagumo equation using cubic B-spline functions
Authors: Hayat Afzaal Mubashir , Abbas Muhammad , Abdullah Farah Aini , Nazir Tahir , Sidi Hamed Ould , Emadifar Homan , Alruwaili Amani 
Published: January 2024

Abstract
The generalization of the classical FitzHugh–Nagumo model provides a more accurate description of the physical phenomena of neurons by incorporating both nonlinearity and fractional derivatives. In this article, we present a numerical method for solving the time-fractional FitzHugh–Nagumo equation (TFFNE) in the sense of the Atangana–Baleanu fractional derivative using B-spline functions. The proposed method employs a finite difference scheme to discretize the fractional derivative in time, while

θ

\theta

-weighted scheme is used to discretize the space directions. The efficiency of the scheme is demonstrated through numerical results and rate of convergence. The convergence order and error norms are studied at different values of the noninteger parameter, temporal directions, and spatial directions. Finally, the effectiveness of the proposed methodology is examined through the analysis of three applications.
Evolving frontiers: endovascular strategies for the treatment of delayed cerebral ischemia
Authors: Chlorogiannis David-Dimitris , Aloizou Athina-Maria , Mavridis Theodoros , Sänger Jonathan Andreas , Chlorogiannis Anargyros , Madouros Nikolaos , Papanagiotou Panagiotis 
Published: January 2024

Abstract
Cerebral vasospasm and delayed cerebral ischemia represent a very challenging aspect of cerebrovascular pathophysiology, most commonly subarachnoid hemorrhage, with significantly high mortality if left untreated. Considerable advances have been made in medical treatment and prompt diagnosis, while newer endovascular modalities have recently been proposed for cases of resistant cerebral vasospasm. However, there is still paucity of data regarding which and whether a single endovascular technique is non inferior to the pharmacological standard of care. In this review, we aim to summarize the current funds of knowledge concerning cerebral vasospasm and the emerging role of the endovascular techniques for its treatment.
Barrier-Induced Rupture Front Disturbances during the 2023 Morocco Earthquake
Authors: Yagi Yuji , Okuwaki Ryo , Hirano Shiro , Enescu Bogdan , Chikamori Masataro , Yamaguchi Ryo 
Published: January 2024

Abstract
Seismic waveforms, including teleseismic body waves, contain information about the irregular behavior of rupture propagation, which is essential for understanding the evolution process of large earthquakes. Here, a high-degree-of-freedom source inversion is applied to the teleseismic P waves of the 2023 moment magnitude 6.8 Morocco earthquake to reveal the irregular rupture behavior during earthquake growth. The resulting total moment tensor solution is an oblique focal mechanism that exhibits reverse faulting with a strike-slip component. There are two distinct peaks at 2 and 4 s in the moment rate function. The reverse fault component dominates at the beginning of the rupture, but then the strike-slip component increases to the second peak and then decreases. The main rupture propagates first in an east-northeast direction, then both up- and down-dip. The down-dip propagating rupture diminishes shortly, whereas the up-dip propagating rupture becomes dominant. The main rupture propagating in the up-dip direction is temporarily suppressed around a point located at 19 km depth and 10 km east-northeast of the hypocenter (region B). After the rupture propagates surrounding region B, the rupture propagates into region B, where a relatively fast slip rate is observed. It is confirmed that the irregular rupture propagation associated with region B is reproduced even when the model settings and the data sampling interval are slightly changed. The irregular rupture propagation obtained in this study suggests that a barrier with high apparent strength (e.g., high fracture surface energy) can cause the rupture to be initially suppressed within the barrier region, followed by delayed rupture propagation through the apparent barrier. The high-frequency seismic motions caused by such an irregular rupture propagation may have contributed to the increase in earthquake-related damage.
FAKTOR-FAKTOR YANG MEMENGARUHI KEPATUHAN REMAJA PUTRI DALAM MENGKONSUMSI TABLET TAMBAH DARAH DI KOTA BANDUNG
Authors: Yulianti Fenti , Herdhianta Dhimas , Ediyono Suryo 
Published: January 2024

Program pemberian Tablet Tambah Darah (TTD) merupakan salah satu intervensi untuk menurunkan prevalensi anemia pada remaja. Namun cakupan pemberian TTD terutama di Kota Bandung masih rendah dibanding dengan wilayah lainnya di Jawa Barat. Salah satu faktor yang memengaruhi cakupan program adalah kepatuhan remaja dalam mengonsumsi TTD. Kepatuhan merupakan perilaku individu yang dipengaruhi oleh niat yang dapat diprediksi dengan menggunakan Teori Perilaku Terencana. Tujuan penelitian adalah menganalisis faktor manakah yang paling berpengaruh terhadap kepatuhan remaja putri berdasarkan teori perilaku terencana. Penelitian menggunakan metode Survey Potong Lintang. Populasi dalam penelitian ini adalah remaja putri di Kota Bandung. Besar sampel sebanyak 68 remaja putri kelas X yang diambil dengan menggunakan tehnik Multistage sampling. Instrumen penelitian menggunakan kuesioner berdasarkan kaidah teori perilaku terencana untuk mengukur intensi/niat dan The eight-item Morisky Medication Adherence Scale (MMAS-8) untuk mengukur kepatuhan. Analisis statistik menggunakan uji regresi Linear Berganda. Hasil Penelitian menyimpulkan bahwa sebagian besar remaja putri di Kota Bandung tidak patuh dalam mengkonsumsi TTD yaitu 83,35% sedangkan faktor yang paling berpengaruh terhadap kepatuhan remaja berdasarkan komponen teori perilaku terencana adalah Outcome Evaluation (p=0,01). Hasil penelitian dapat dijadikan dasar dalam penyusunan strategi program promosi kesehatan untuk meningkatkan kepatuhan remaja puteri dalam mengkonsumsi TTD dengan menekankan pada aspek materi mengenai manfaat mengonsumsi TTD untuk menurunkan anemia pada remaja putri.
STUDI IMPLEMENTASI MODEL PEMBELAJARAN PROJECT BASED LEARNING DALAM PENERAPAN KURIKULUM MERDEKA PADA PEMBELAJARAN MATEMATIKA DI SMA NEGERI 8 BANJARMASIN
Authors: Wulandari Ananda Putri , Zulkarnain Iskandar , Noorbaiti Rahmita 
Published: January 2024

Model Project Based Learning (PjBL) merupakan salah satu model yang dianjurkan untuk diterapkan pada Kurikulum Merdeka. Model ini mengacu pada metode instruksional berbasis inkuiri yang melibatkan siswa dalam konstruksi pengetahuan dengan memberikan proyek dan mengembangkan produk pembelajaran. Tujuan penelitian ini adalah untuk mengetahui aktivitas siswa, respon siswa dan kendala pada implementasi model pembelajaran Project Based Learning dalam Kurikulum Merdeka terhadap pembelajaran matematika di SMA Negeri 8 Banjarmasin. Penelitian ini menggunakan jenis penelitian deskriptif dengan metode penelitian gabungan (mixed methods) antara metode kuantitatif dan kualitatif. Instrumen penelitian ini terdiri dari lembar observasi, angket respon siswa dan pedoman wawancara. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi, angket, wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa: (1) Aktivitas siswa pada implemetasi model Project Based Learning terhadap Kurikulum Merdeka termasuk pada kriteria sangat baik. (2) Respon siswa terhadap model Project Based Learning telah memenuhi kriteria respon positif yaitu 91%. (3) Kendala yang terdapat pada implemetasi model Project Based Learning adalah kesulitan terhadap materi prasyarat, membutuhkan banyak waktu untuk menyelesaikan proyek serta memerlukan fasilitas, alat dan bahan yang mendukung. Kata kunci: Kurikulum Merdeka, Project Based Learning, Pembelajaran Matematika. Abstract: Project Baesd Learning (PjBL) Model is one of the recommended models to be applied to the Merdeka Curriculum. This model refers to an inquiry-based instructional method that engages students in knowledge construction by providing projects and developing learning products. The purpose of this study was to find out student activity, student responses and obstacles on the application of the Project Based Learning model in Merdeka Curriculum towards learning mathematics at SMA Negeri 8 Banjarmasin. This research is a descriptive research type with a combined research method (mixed methods) between quantitative and qualitative methods. The research instruments consisted of observation sheets, student response questionnaires and interview guidelines. The data collection techniques used in this research were observation, questionnaire, interview and documentation. The results showed that: (1) Student activity in implementing the Project Based Learning model of the Merdeka Curriculum is included in the very good criteria. (2) Student responses to the Project Based Learning model has met the positive response criteria of 91%. (3) Obstacles found in the implementation of Project Based Learning model are difficulties in prerequisite material, taking a lot of time to complete the project and requiring adequate facilities, tools and materials.Keywords: Merdeka Curriculum, Project Based Learning, Mathematics Learning.
Pengaruh Kompetensi dan Motivasi Terhadap Kepuasan Kerja Karyawan Selama Masa Pandemi Covid-19 di PT. Kao Indonesia
Authors: Gumay Olivia Augesthania Putri , Masruchiyah Nieke , Ratnasih Cicih 
Published: January 2024

PT KAO Indonesia adalah perusahaan multinasional yang bergerak di bidang manufaktur dan distribusi produk konsumsi yang secara garis besar dikelompokkan dalam 3 kategori sebagai berikut: Health & Beauty, Hygiene & Living dan Baby Diapers. Penelitian ini menggunakan pendekatan kuantitatif dan metode penelitian yang datanya berupa angka dan digunakan untuk mengukur sebuah subjek atau objek penelitian. Penelitian ini dimaksudkan untuk menjelaskan pengaruh kompetensi dan motivasi terhadap kepuasan kerja yang berdampak pada kinerja selama masa pandemi covid-19. Hasil penelitian dari analisis pengaruh langsung maupun tidak langsung pada variabel kompetensi dan motivasi terhadap kepuasan kerja yang berdampak pada kinerja selama masa pandemi covid-19 di PT. KAO Indonesia maka dapat disimpulkan yaitu sebagai berikut : 1. Pada variabel penelitian kompetensi dan motivasi dalam mempengaruhi kinerja dinyatakan bahwa signifikan dengan nilai 0,000 dalam uji simultan F dikatakan dapat mempengaruhi. 2. Variabel Kompetensi memiliki pengaruh positif terhadap kepuasan kerja hal ini dibuktikan dengan tingkat signifikansi dengan nilai 0,000 dan nilai koefisien regresi sebesar 0,367. Hal ini membuktikan bahwa hipotesis pertama diterima. 3. Variabel Motivasi memiliki pengaruh positif terhadap kepuasan kerja hal ini dibuktikan dengan tingkat signifikansi dengan nilai 0,000 dan nilai koefisien regresi sebesar 0,401. Hal ini menunjukkan bahwa hipotesis kedua diterima.
Multidimensional Fluoroscopy to Assess Closed Reduction in Displaced Young Femoral Neck Fractures
Authors: Haase Douglas R. , Achor Timothy S. , Choo Andrew M. , Warner Stephen J. 
Published: January 2024

Case:
The authors present 3 physiologically young patients with displaced femoral neck fractures who underwent initial closed reduction and provisional fixation. Multidimensional fluoroscopy was used to assess fracture reduction before definitive fixation, with 1 patient requiring an open approach because of inadequate fracture reduction after closed attempts.

Conclusion:
Displaced femoral neck fractures in young patients remain difficult injuries to treat. Reduction quality is a significant predictor of patient outcomes. Intraoperative multidimensional fluoroscopy provides treating surgeons with a tool to assess fracture reduction after closed reduction maneuvers and allows for intraoperative treatment adjustment as needed.
Kajian Animal Welfare Pemotongan Sapi di Rumah Potong Hewan melalui Profil Molekul Stres
Authors: Rodli Muhammad Hilman , Fadli Cahya Ana , Azzumar Abdul Aziz , Islami Darajatun , Ma’rifah Shofia Jannatul , Humaidah Nurul 
Published: January 2024

Proses pemotongan hewan di Rumah Potong Hewan (RPH) harus dilakukan dengan baik dari pengangkutan hingga pemotongan agar tidak berakibat stres dan kesakitan pada hewan. Tujuan penelitian adalah untuk mengevaluasi apakah proses pemotongan ternak sapi di RPH telah memenuhi standar dan menerapkan prinsip animal welfare. Materi penelitian adalah 20 ekor Sapi Limosin dengan rata-rata bobot badan ±350 kg. Metode Penelitian adalah survey. Kasus yang diamati adalah kedaan fisiologis sebelum penyembelihan (P1) dan setelah penyembelihan (P2). Variabel yang diamati adalah kadar hormon Cortisol, Malondialdehid (MDA), Superoksida Dimustase (SOD). Data dianalisa menggunakan tabel anova dan menggunakan uji t. Hasil riset menunjukkan bahwa Kortisol dan MDA sebelum dilakukan penyembelihan (P1) berbeda sangat nyata (P≤0,01) dengan setelah dilakukan penyembelihan (P2). Rata-rata kadar hormon Kortisol sebelum penyembelihan adalah 47,6±1,22 nmol/L dan setelah penyembelihan adalah 58,16±2,22 nmol/L. Kadar MDA (P1) adalah 20,02±0,73 mmol/L dan P2 dalah 30,91±0,99 mmol/L. Kadar SOD sebelum penyembelihan (P1) berbeda nyata dengan setelah penyembelihan (P2). Rata-rata kadar SOD (P1) adalah 4,68±0,47 mmol/L dan (P2) adalah 3,78±0.08 mmol/L. Kesimpulan adalah perlakuan pemotongan di RPH masih menunjukkan adanya stres pada ternak. Saran dilakukan upaya pengurangan stres pada ternak terutama pada saat perobohan ternak sebelum disembelih.