bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explainable artificial intelligence‐driven mask design for self‐supervised seismic denoising
Authors: Birnie Claire , Ravasi Matteo 
Published: January 2024

AbstractThe presence of coherent noise in seismic data leads to errors and uncertainties, and as such it is paramount to suppress noise as early and efficiently as possible. Self‐supervised denoising circumvents the common requirement of deep learning procedures of having noisy‐clean training pairs. However, self‐supervised coherent noise suppression methods require extensive knowledge of the noise statistics. We propose the use of explainable artificial intelligence approaches to ‘see inside the black box’ that is the denoising network and use the gained knowledge to replace the need for any prior knowledge of the noise itself. This is achieved in practice by leveraging bias‐free networks and the direct linear link between input and output provided by the associated Jacobian matrix; we show that a simple averaging of the Jacobian contributions over a number of randomly selected input pixels provides an indication of the most effective mask to suppress noise present in the data. The proposed method, therefore, becomes a fully automated denoising procedure requiring no clean training labels or prior knowledge. Realistic synthetic examples with noise signals of varying complexities, ranging from simple time‐correlated noise to complex pseudo‐rig noise propagating at the velocity of the ocean, are used to validate the proposed approach. Its automated nature is highlighted further by an application to two field data sets. Without any substantial pre‐processing or any knowledge of the acquisition environment, the automatically identified blind masks are shown to perform well in suppressing both trace‐wise noise in common shot gathers from the Volve marine data set and coloured noise in post‐stack seismic images from a land seismic survey.
Chronic anthropogenic disturbance mediates the biodiversity‐productivity relationship across stand ages in a large temperate forest region
Authors: Lin Senxuan , Fan Chunyu , Wang Juan , Zhang Chunyu , Zhao Xiuhai , von Gadow Klaus 
Published: January 2024

Abstract

Temperate forests, especially those in the densely populated regions of the world, are experiencing increasing levels of habitat degradation and biological impoverishment due to subtle but pervasive chronic anthropogenic disturbances including frequent and continuous grazing and extraction of non‐timber forest products. However, the effects of these subtle, chronic disturbances on the biodiversity‐productivity relationship have rarely been examined especially in forests at different development stages. Accordingly, this study explores how chronic anthropogenic disturbance affects the relationship between tree species diversity and forest productivity at different stand development stages in a large temperate forest region.

We used the human footprint index as a proxy for chronic human disturbance. Hierarchical Bayesian models were employed to assess the effects of chronic human disturbance on the relationship between tree diversity and forest productivity across different stand age. Several measures of diversity were employed, including taxonomic, functional and phylogenetic diversity.

Forest productivity consistently increased with taxonomic, functional and phylogenetic biodiversity; these biodiversity facets were the main drivers of forest productivity compared to stand age, chronic human disturbance and climate. However, the magnitude at which productivity increases with the increments of taxonomic and functional diversity diminishes with the increasing chronic disturbance, especially in younger stands. The effects of phylogenetic diversity on productivity did not vary with chronic disturbance, regardless of stand age.

Synthesis and applications: Chronic human disturbance in a large temperate forest region reduces the increase in community productivity due to different facets of biodiversity, especially in young forests. The evidence suggests that the mitigation of chronic human disturbance and the conservation of biodiversity will be effective in sustaining essential ecosystem functions.
Do Pre‐merger Loyalties Help or Hinder Post‐merger Retention? A Longitudinal Study
Authors: Edwards Martin R. , Lipponen Jukka , Kaltiainen Janne , Hornsey Matthew 
Published: January 2024

AbstractMergers potentially threaten employees’ organizational identities. For some, a merger could be a trigger to seek employment elsewhere, but the factors associated with increased withdrawal cognitions post‐merger necessitate further research. Using a longitudinal, pre‐ and post‐merger design, we investigated two competing predictions drawing on social identity theory: a vulnerability hypothesis (high identification with the pre‐merger organization will be associated with increased withdrawal cognitions over time) versus a buffer hypothesis (high pre‐merger identification will be associated with decreased withdrawal cognitions over time). Employees from two public sector organizations were surveyed two months before and 22 months after a merger (N = 869). Consistent with the buffer hypothesis, higher pre‐merger identification was associated with lower pre‐to‐post‐merger withdrawal cognitions. We found that this relationship was moderated by both pre‐merger professional and workgroup identification, highlighting the importance of considering multifoci identification patterns in a merger context. Findings indicate that work‐related identification plays a key buffering role through organizational‐level change, with pre‐merger identification potentially helping retain staff through the merger storm. Thus, our study contributes to social identity theory by showing that an abundance of pre‐merger identification forms should help employees navigate the challenges faced during the change experienced with an organizational merger.
Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy
Authors: Wipperman Matthew F. , Gayvert Kaitlyn M. , Atanasio Amanda , Wang Claire Q. , Corren Jonathan , Covarrubias Angelica , Setliff Ian , Chio Erica , Laws Elizabeth , Wolfe Kelley , Harel Sivan , Maloney Jennifer , Herman Gary , Orengo Jamie M. , Lim Wei Keat , Hamon Sara C. , Hamilton Jennifer D. , O'Brien Meagan P. 
Published: January 2024

AbstractBackgroundNasal epithelial cells are important regulators of barrier function and immune signaling; however, in allergic rhinitis (AR) these functions can be disrupted by inflammatory mediators. We aimed to better discern AR disease mechanisms using transcriptome data from nasal brushing samples from individuals with and without AR.MethodsData were drawn from a feasibility study of individuals with and without AR to Timothy grass and from a clinical trial evaluating 16 weeks of treatment with the following: dupilumab, a monoclonal antibody that binds interleukin (IL)‐4Rα and inhibits type 2 inflammation by blocking signaling of both IL‐4/IL‐13; subcutaneous immunotherapy with Timothy grass (SCIT), which inhibits allergic responses through pleiotropic effects; SCIT + dupilumab; or placebo. Using nasal brushing samples from these studies, we defined distinct gene signatures in nasal tissue of AR disease and after nasal allergen challenge (NAC) and assessed how these signatures were modulated by study drug(s).ResultsTreatment with dupilumab (normalized enrichment score [NES] = −1.73, p = .002) or SCIT + dupilumab (NES = −2.55, p < .001), but not SCIT alone (NES = +1.16, p = .107), significantly repressed the AR disease signature. Dupilumab (NES = −2.55, p < .001), SCIT (NES = −2.99, p < .001), and SCIT + dupilumab (NES = −3.15, p < .001) all repressed the NAC gene signature.ConclusionThese results demonstrate type 2 inflammation is an important contributor to the pathophysiology of AR disease and that inhibition of the type 2 pathway with dupilumab may normalize nasal tissue gene expression.
Previous cancers in women diagnosed with premature ovarian insufficiency: A nationwide population‐based case–control study
Authors: Silvén Heidi , Savukoski Susanna M. , Pesonen Paula , Niinimäki Riitta , Pukkala Eero , Gissler Mika , Suvanto Eila , Niinimäki Maarit 
Published: January 2024

AbstractIntroductionTo investigate the occurrence of previous cancer diagnoses in women suffering from premature ovarian insufficiency (POI) and compare it with the general population, shedding light on the association between cancer, cancer treatments, and POI.Material and methodsWe conducted a nationwide case–control study based on registry data from various sources, including the Social Insurance Institution, Finnish Population Information System, and Finnish Cancer Registry spanning from 1953 to 2018. Our participants comprised all women in Finland who, between 1988 and 2017, received hormone replacement therapy reimbursement for ovarian insufficiency before the age of 40 years (n = 5221). Controls, matched in terms of age and municipality of residence, were selected from the Finnish Population Information System (n = 20 822). Our main exposure variable was a history of cancer diagnosis preceding the diagnosis of POI. We analyzed odds ratios (OR) to compare the prevalence of previous cancers in women with POI with that in controls, stratifying results based on cancer type, age at cancer diagnosis, and the time interval between cancer diagnosis and POI. We also assessed changes in OR for previous cancer diagnoses over the follow‐up period.ResultsOut of the women diagnosed with POI, 21.9% had previously been diagnosed with cancer, resulting in an elevated OR of 36.5 (95% confidence interval [CI] 30.9 to 43.3) compared with 0.8% of the controls. The risk of developing POI was most pronounced during the first 2 years following a cancer diagnosis, with an OR of 103 (95% CI 74.1 to 144). Importantly, this risk remained elevated even when the time interval between cancer and POI exceeded 10 years, with an OR of 5.40 (95% CI 3.54 to 8.23).ConclusionsThis study reveals that 21.9% of women with POI have a history of cancer, making the prevalence of cancer among these women 27.5 times higher than age‐matched controls in the Finnish population. The risk of developing POI is most substantial in the first 2 years following a cancer diagnosis. These findings underscore the role of cancer treatments as an etiological factor for POI and emphasize the importance of recognizing the risk of POI in cancer survivors for early diagnosis and intervention.
Longitudinal changes in optical coherence tomography angiography characteristics in normal‐tension glaucoma with or without high myopia
Authors: Lai Chin , Chuang Lan‐Hsin , Lai Chi‐Chun , Liu Chun‐Fu , Yang Ju‐Wen , Chen Henry S. L. 
Published: January 2024

AbstractPurposeTo evaluate the structural, microvascular, and functional progression of normal tension glaucoma (NTG) with or without high myopia by examining longitudinal changes in optical coherence tomography angiography (OCTA) and visual field (VF) parameters.MethodsWe evaluated 61 NTG eyes and classified 25 of the eyes with axial lengths (ALs) of ≥26 mm as highly myopic. We assessed the rate of change in OCTA parameters, namely radial peripapillary capillary (RPC) vessel density (VD), parafovea VD, deep parafovea VD, retinal nerve fibre layer (RNFL) thickness, and ganglion cell complex thickness. We evaluated the correlation of the rate of change in OCTA parameters with VF loss and AL.ResultsAmong the 61 NTG eyes, rates of loss of RPC VD, parafovea VD, deep parafovea VD, and RNFL thickness were significantly different from zero despite the nonsignificant rate of change in VF mean deviation (MD). Changes in these OCTA parameters did not differ significantly in highly myopic NTG eyes. The rate of change in VF MD was significantly correlated with the rate of change in parafovea VD in highly myopic and non‐highly myopic NTG eyes. In highly myopic NTG eyes, AL was negatively correlated with the rates of loss of RNFL thickness, VF MD, and VF PSD.ConclusionNTG eyes with a relatively stable VF exhibited loss of VD and RNFL thickness. VF progression in NTG was correlated with decreasing parafovea VD, indicating a structure–function correlation. Greater AL may indicate faster VF loss and RNFL thinning in highly myopic NTG eyes.
Eat healthy, feel better: Are differences in employees' longitudinal healthy‐eating trajectories reflected in better psychological well‐being?
Authors: Koch Theresa J. S. , Arnold Maike , Völker Jette , Sonnentag Sabine 
Published: January 2024

AbstractEating healthily in terms of fruit and vegetable consumption has beneficial effects for employees and their organisations. Yet, we know little about how employees' eating behaviour develops over longer periods of time (trajectories) as well as about how subgroups of employees in these trajectories differ (trajectory classes). Gaining such insights is critical to understand how employees address healthy eating recommendations over time as well as to develop individualised interventions that also consider the development of healthy eating (i.e. improvement versus impairment beyond mean levels). We analysed panel data (Longitudinal Internet Studies for the Social Sciences) from 1054 employees by means of growth mixture modelling. Our analyses revealed three relevant classes of healthy‐eating trajectories: a favourable trajectory class, an unfavourable trajectory class and a strongly improving trajectory class. Furthermore, unfavourable healthy‐eating trajectories were especially critical with respect to impaired psychological well‐being. Specifically, we found robust results for impaired positive and negative affects, but not for self‐esteem, in the unfavourable trajectory class. We discuss limitations and implications of these findings, thereby encouraging research and practice to further consider such fine‐grained approaches (i.e. focusing on subgroups within a larger population) when addressing healthy‐eating promotion over time.
Traumatic losses permeate daily emotional experiences: roles of daily uplifts and subjective age
Authors: Early Alexandra S. , Reynolds Caitlin M. , Neupert Shevaun D. 
Published: January 2024

AbstractDaily emotional experiences may vary depending on a stressor's intensity or source. The present study aimed to examine the interaction between traumatic loss, daily uplifts, and daily subjective age predicting daily negative affect. Results from a 14‐day daily diary study of 440 US adults aged 50–85 showed that daily increases in uplifts were associated with decreases in negative affect, especially for those who reported a traumatic loss when they also experienced increases in subjective age. Based on our study, daily events and perceptions can have a considerable impact on daily functioning and may serve as important mechanisms after a traumatic loss. Although traumatic losses may impact individuals differently, incorporating daily uplifts, based on available resources and capacities, may foster daily emotional well‐being.
Fostering circular economy through open innovation: Insights from multiple case study
Authors: Perotti Francesco Antonio , Bargoni Augusto , De Bernardi Paola , Rozsa Zoltan 
Published: January 2024

AbstractThis study represents an empirical, comprehensive investigation of two different inter‐organisational collaborative approaches, offering a novel perspective on collaborative circular business models in the modern economy. In this vein, we explore how open innovation strategies foster the implementation of circular economy practices within a circular supply chain and a circular ecosystem. In addition, we identify and characterise stakeholders' roles in facilitating the translation of circular principles into a viable business. An inductive theorising approach was employed, leveraging an explorative multiple case study methodology. Data were collected from 13 organisations involved in two collaborative networks, designed to establish upcycling practices to recover waste from the food and beverage industry. A critical realist philosophical positioning underpinned researchers' data collection and analysis. As a result, we outline the nature of two different collaborative approaches to pursue a regenerative production system through open innovation strategies: a circular supply chain and a circular ecosystem architecture. The characterisation of the coordinator and orchestrator of collaborative circular business models is also highlighted in our findings. In sum, this study contributes to the literature on circular economy by unveiling the role of open innovation in fostering circular business development. From a practical standpoint, it offers insights for managers of sustainability‐oriented companies willing to implement upcycling practices.
Variant ALK‐fusion positive anaplastic large cell lymphoma (ALCL): A population‐based paediatric study of the NHL‐BFM study group
Authors: Luedersen Jette , Stadt Udo zur , Richter Julia , Oschlies Ilske , Klapper Wolfram , Rosenwald Andreas , Kalinova Marketa , Simonitsch‐Klupp Ingrid , Siebert Reiner , Zimmermann Martin , Qi Minyue , Nakel Jacqueline , Scheinemann Katrin , Knörr Fabian , Attarbaschi Andishe , Kabickova Edita , Woessmann Wilhelm , Damm‐Welk Christine 
Published: January 2024

SummaryFrequency, distribution and prognostic meaning of ALK‐partner genes other than NPM1 in ALK‐positive anaplastic large‐cell lymphoma (ALCL) are unknown. Forty‐nine of 316 ALCL diagnosed in the NHL‐BFM study group showed no nuclear ALK expression suggestive of a variant ALK‐partner; 41 were analysed by genomic capture high‐throughput sequencing or specific RT‐PCRs. NPM1::ALK was detected in 13 cases. Among the 28 patients with a non‐NPM1::ALK‐fusion partner, ATIC (n = 8; 29%) and TPM3 (n = 9; 32%) were the most common. Five of eight patients with ATIC::ALK‐positive ALCL relapsed, none of nine with TPM3::ALK. Variant ALK‐partners are rare and potentially associated with different prognoses.
Increased erythroferrone levels in malarial anaemia
Authors: Neyer Peter J. , Kaboré Bérenger , Nakas Christos T. , Diallo Salou , Tinto Halidou , Post Annelies , van der Ven Andre J. , Huber Andreas R. , Largiadèr Carlo R. , Hammerer‐Lercher Angelika 
Published: January 2024

SummaryWe assessed the diagnostic potential of erythroferrone as a biomarker for iron homeostasis comparing iron deficiency cases with anaemia of inflammation and controls. The dysregulation of the hepcidin axis was observed by Latour et al. in a mouse model of malarial anaemia induced by prolonged Plasmodium infection leading to increased erythroferrone concentrations. In line with that, we found significantly higher erythroferrone levels in cases with malaria and anaemia in an African population, compared to asymptomatic controls. Therefore, our findings extend the previous ones of the mouse model, suggesting also a dysregulation of the hepcidin axis in humans, which should be further corroborated in prospective studies and may lay the basis for the development of improved treatment strategies according to ERFE concentrations in such patients.
Soluble CD27 as a predictive biomarker for intra‐tumoral CD70/CD27 interaction in nasopharyngeal carcinoma
Authors: Nagato Toshihiro , Komatsuda Hiroki , Hayashi Ryusuke , Takahara Miki , Ujiie Nanami , Kosaka Akemi , Ohkuri Takayuki , Oikawa Kensuke , Sato Ryosuke , Wakisaka Risa , Kono Michihisa , Yamaki Hidekiyo , Ohara Kenzo , Kumai Takumi , Kishibe Kan , Katada Akihiro , Hayashi Tatsuya , Kobayashi Hiroya 
Published: January 2024

AbstractIn CD70‐expressing tumors, the interaction of CD70 on tumor cells with its lymphocyte receptor, CD27, is thought to play a role in immunosuppression in the tumor microenvironment and elevated serum levels of soluble CD27 (sCD27). Previous studies showed that CD70 is expressed in nasopharyngeal carcinoma (NPC), an Epstein–Barr virus (EBV)‐related malignancy. However, the association between intratumoral CD70/CD27 expression and serum levels of sCD27 in NPC remains unclear. In the present study, we show that CD70 is primarily expressed by tumor cells in NPC and that CD27‐positive lymphocytes infiltrate around tumor cells. NPC patients with CD27‐positive lymphocytes had significantly better prognosis than patients lacking these cells. In addition, high CD70 expression by tumor cells tended to be correlated with shorter survival in NPC patients with CD27‐positive lymphocytes. Serum sCD27 levels were significantly increased in patients with NPC and provided good diagnostic accuracy for discriminating patients from healthy individuals. The concentration of serum sCD27 in patients with CD70‐positive NPC with CD27‐positive lymphocytes was significantly higher than in patients with tumors negative for CD70 and/or CD27, indicating that the intratumoral CD70/CD27 interaction boosts the release of sCD27. Furthermore, positive expression of CD70 by NPC cells was significantly correlated with EBV infection. Our results suggest that CD70/CD27‐targeted immunotherapies may be promising treatment options and that sCD27 may become an essential tool for evaluating the applicability of these therapies by predicting the intratumoral CD70/CD27 interaction in NPC.
Antitumor activity of α‐pinene in T‐cell tumors
Authors: Abe Masaya , Asada Noboru , Kimura Maiko , Fukui Chie , Yamada Daisuke , Wang Ziyi , Miyake Masayuki , Takarada Takeshi , Ono Mitsuaki , Aoe Michinori , Kitamura Wataru , Matsuda Masayuki , Moriyama Takashi , Matsumura Akifumi , Maeda Yoshinobu 
Published: January 2024

AbstractT‐cell acute leukemia and lymphoma have a poor prognosis. Although new therapeutic agents have been developed, their therapeutic effects are suboptimal. α‐Pinene, a monoterpene compound, has an antitumor effect on solid tumors; however, few comprehensive investigations have been conducted on its impact on hematologic malignancies. This report provides a comprehensive analysis of the potential benefits of using α‐pinene as an antitumor agent for the treatment of T‐cell tumors. We found that α‐pinene inhibited the proliferation of hematologic malignancies, especially in T‐cell tumor cell lines EL‐4 and Molt‐4, induced mitochondrial dysfunction and reactive oxygen species accumulation, and inhibited NF‐κB p65 translocation into the nucleus, leading to robust apoptosis in EL‐4 cells. Collectively, these findings suggest that α‐pinene has potential as a therapeutic agent for T‐cell malignancies, and further investigation is warranted.