bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between whole-blood serotonin level and flexible pes planovalgus deformity in children and adolescents
Authors: Aranovich A. M. , Winderlich M. E. , Shchekolova N. B. 
Published: October 2023

Introduction Timely diagnosis, etiopathogenesis, treatment and prevention of the progression of pediatric flexible pes planovalgus (FPPV) are essential to prevent irreversible complications.The objective was to determine a correlation between whole-blood serotonin level and flexible pes planovalgus in children and adolescents over a period of four years with progression of the condition.Material and methods The whole-blood serotonin level was measured in children and adolescents aged 5-15 years with FPPV and compared with data from photoplantograms, a pronation angle of the calcaneus and radiographs of the feet. Based on serotonin measurements and photoplantograms, two groups were identified according to the course of flexible pes planovalgus and measurements during the next four years.Results Normal serotonin levels were maintained in the non-progressive FPPV group throughout the study with a 9.2 % decrease in the pronation of the calcaneus at 4 years. Progressive FPPV patients showed higher serum serotonin at one year with a 38.3 % increase at 4 years, increased pronation of the calcaneus by 21.2% and radiologically decreased height of the arch by 18.7 %. A moderate correlation between whole-blood serotonin levels, pronation of the calcaneus and the height of the foot arch was radiologically revealed in patients with a different course of FPPV. Analysis of the diagnostic effectiveness of the whole-blood serotonin test in patients with FPPV showed high sensitivity and specificity in predicting the risk of progression of FPPV.Discussion Literature review showed a paucity of research on clinical and laboratory detection of the progression of FPPV and examination of neurotransmitter mechanisms in the foot pathology. Plantography, 3D scanning and radiography were the main methods for the diagnosis of the flat feet.Conclusion The correlation between whole-blood serotonin level and flexible pes planovalgus in children and adolescents was identified and suggested involvement of the serotoninergic system in the formation and progression of foot pathology.
Revision total hip arthroplasty with custom-made hip implant for Paprosky type IV femoral bone loss
Authors: Kovaldov K. A. , Morozova E. A. , Gerasimov E. A. , Gerasimov S. A. 
Published: October 2023

Introduction Replacement of extensive Paprosky type IIIB and type IV bone loss is a challenge in revision total hip arthroplasty (THA).The purpose was to demonstrate the possibility of femoral reconstruction in proximal femur bone loss using a custom-made implant for revision THA.Material and methods We report a case of a 72-year-old patient with an extensive Paprosky type IV femoral defect, which was replaced using a custom-made modular component.Results The femoral defect was successfully augmented with a custom-made modular component, and the hip function was restored. The locking mechanism of the constrained system failed at 6 months with the joint remained stable. The patient could ambulate with additional support. VAS, HHS and HOOS scores measured before and after 2 years showed positive dynamics.Discussion Paprosky type IIIB and type IV defects are a challenge for revision hip arthroplasty. There is a variety of surgical options with outcomes being ambiguous. Modular and monoblock tapered stems, the technique of impacted bone graft have been reported to have excellent results in revision THA with Paprosky type III and IV defects. A custom-made femoral component was developed based on the principle of modular stems. Joint stability is a concomitant problem with a severe bone defect that can be addressed with a double mobility or constrained system. Both methods are associated with a sufficient number of complications.Conclusion Replacement of a Paprosky type IV femoral defect with a custom-made modular component demonstrated satisfactory outcomes at a two‑year follow-up. The patient had no complaints, could ambulate unassisted using an elbow crutch and positively evaluated the result of treatment.
Ceramic-related noise as an adverse outcome in total hip arthroplasty
Authors: Tashtanov B. R. , Kirilova I. A. , Pavlova D. V. , Pavlov V. V. 
Published: October 2023

Introduction Ceramic hip replacement bearings have shown to be low wearing and biocompatible. The last two generations of Biolox Forte and Biolox Delta ceramics have have established themselves as durable bearings. However, squeaking and noise from ceramic bearing THRs is well recognised in the 21st century.The objective was to explore the problem of noise in the ceramic bearing of THA based on the analysis of the foreign and Russian literature.Material and methods In presented the analysis of Foreign and Russian literature searches for the review were produced according to PRISMA recommendations using PubMed, Scopus, Google Scholar, eLibrary. MINOR was used to assess the methodological quality of articles.Results and Discussion Noise in ceramics is observed in 37.7 %. There are many theories on the origin and mechanism of noise including liner impingement and loading, film disruption, third body, microseparation and resonance. However, there is still no consensus on what is noise in the ceramic bearing and how to solve this problem.Conclusion Literature review of ceramic bearing indicated enough unanswered questions. The noise may play a role as a predictor of improper use of endoprosthesis with accumulated database resulting in better understanding of the phenomenon, methods of the correction and timely prevention of ceramic breakage.
Determination of SPF Value and Total Tannin in Ethyl Acetate Fraction of Peronema canescens Jack
Authors: Khairunnisa Amalia , Fadlilaturrahmah Fadlilaturrahmah , Septiany Septiany 
Published: October 2023

Daun Sungkai (Peronema canescens Jack) mengandung metabolit sekunder antara lain tannin, alkaloid, terpenoid, steroid, dan flavonoid. P. canescens merupakan tanaman asli Kalimantan Selatan yang berpotensi sebagai perawatan kulit alami berdasarkarkan kandungan tannin yang memiliki aktivitas antioksidan sehingga dapat dikembangkan sebagai produk tabir surya. Penelitian ini bertujuan untuk menentukan nilai SPF dan tannin total fraksi etil asetat daun Sungkai (P. canescens) menggunakan spektrofotometri UV-Vis. Metode ekstraksi dilakukan dengan maserasi menggunakan etanol 96% dan penggunaan fraksi n-heksana dan etil asetat. Penentuan tanin total menggunakan standar katekin dengan konsentrasi 40,60, 80, 100 dan 120 ppm. Hasil kadar tannin total sebesar 0,5586% ±0.01516 ekivalen katekin dan nilai SPF sebesar 5.703±0.021. Dengan demikian dapat disimpulkan daun Sungkai (Peronema canescens Jack) dapat dikembangkan sebagai tabir surya alami. Kata Kunci: Daun Sungkai, Tabir Surya, Tannin Total, UV-Vis, SPF Sungkai leaves (Peronema canescens Jack). contains secondary metabolites i.e tannins, alkaloids, terpenoids, steroids, and flavonoids. P. canescens, natural plant from South Kalimantan, has potential benefits as natural skincare based on tannin which contains antioxidant activity that can be developed as a sunscreen product. This study aimed to determine the sun protection factor (SPF) and total tannin ethyl acetate fraction of sungkai leaves (P. canescens) using UV-vis spectrophotometry. The extraction method was maceration with 96% ethanol and the fraction used n-hexane and ethyl acetate. The determination of total tannin with catechin standards concentration 40,60,80, 100 and 120 ppm. The result of total tannin was 0.5586% ±0.01516 catechin equivalents and the SPF value was 5.703±0.021. The conclusion of the research is that Peronema canescens Jack can be developed into natural sunscreen.
Subglacial tills: a process model based on microsedimentological clues
Authors: Menzies John , Paulen Roger C. , Reitner Jürgen M. , Gao Cunhai , Hodder Tyler , Ross Martin 
Published: October 2023

Abstract
Subglacial sediments are subject to erosion, transport, and deposition in active, ephemeral, and spatially localized glacial environments. It is critical to determine how these mobilized sediments become immobilized in a time-transgressive process and can be frequently remobilized and reimmobilized. Microscopic sedimentary structural signatures provide invaluable information on subglacial processes and contribute to understanding till formation. Data were obtained from a series of field sites in Canada and Austria investigating the microsedimentological aspects of both alpine and continental glaciation tills to construct a conceptual model of subglacial deformation. Microstructures in these tills indicate rheological behaviors that can be summarized into a potential model for soft deforming subglacial sediments. Most microstructures noted in these subglacial till examples highlight the development of subglacial interface kinematics providing clues to till deposition mechanics, subglacial bedform development, and the processes involved in till provenance distributions. A conceptual process model of subglacial interface conditions in soft mobile sediments is developed that uses microsedimentological evidence and highlights how an active ice mass integrates with ongoing substrate deformation. In the model, interaction occurs between the ice and its sediment bed with internal sediment microstructures evolving where multiple transient shear deformation processes cause localized deformation linked to pervasive and nonpervasive sediment deformation.
Design of integral backstepping controller - sliding mode along with admittance controller of knee joint robot in the presence of noise
Authors: jalalnezhad mostafa , Lin Xingmin , Xia Luting , Ruoyi Zhao , Shieh Charles 
Published: October 2023

Abstract

Nowadays, the using of robots in the field of rehabilitation has been increased, vehemently. Rehabilitation robots are designed to assist people who have physical disabilities. Patients often have the substantial limitation in movement. The knee joint as the largest blockage in the human body is always vulnerable to injury, some knee joint rehabilitation treatments are provided by physiotherapists by practicing the patient's leg around the knee joint to strengthen the knee-strengthened muscles to the patient gets his health. Most exercises that physiotherapists do is either manual or traditional way. Therefore, researchers are interested in designing a device to help these exercises. In this regard, devices were designed and built, such as Continuous Passive Motion (CPM). The main problems of CPM devices are lack of knowledge (feedback) from the position of the patient's leg and its resistance against the robot motion. Therefore, interactive forces between patient leg and robot will be increased if the patient's leg is unable to track the predetermined trajectory. This phenomenon can hurt the patient. In this thesis, in order to realize the flexible behavior of the robot against the potential force of the individual foot, the concept of admittance as well as impedance are used. At first, the dynamic equations of the robot and the patient leg were extracted and verified using Adams dynamic analytic software. Then, the design of nonlinear controllers is done. In this research, a variety of control methods including a combination of Sliding-Backstepping and Admittance Control, in order to control the knee rehabilitation robot and at the same time creating a soft interactive patient with the patient leg are developed.
Prevalence of Intimate Partner Violence in pregnant women during the COVID-19 epidemic in Qazvin-Iran 2021
Authors: Hadiloo Nahid , Lalooha Fatemeh , Mohammad Ebrahim Sarichloo , Oveisi Sonia 
Published: October 2023

Abstract
Introduction:
Intimate partner violence (IPV) in pregnant women is considered one of the most important types of violence, which can include physical, psychological abuse and sexual violence. During the lockdown due to COVID-19, the home is at risk of becoming a very dangerous place for victims of domestic violence. Herein, we aimed to determine the prevalence of IPV and associated factors in pregnant women in Qazvin, Iran.
Methods:
This cross-sectional study was conducted on 450 pregnant mothers who were referred to the Kowsar Hospital Prenatal Clinic in Qazvin in 2021. Participants were assessed using a questionnaire consisting of four parts (demographic data, Abuse Assessment Screen (AAS) for domestic violence, The Revised Conflict Tactics Scale (CTS2) for IPV. Data were collected and analysis was performed via SPSS software version 22 using a non-parametric test; Mann-Whitney and x2 tests.
Results:
The overall prevalence of IPV was higher in pregnant women than in men in Qazvin. The most common form of IPV was psychological aggression (24.8%), followed by scale of injury (8.2%), physical (3.3%) and sexual (4.2%) violence. In addition, analysis of the AAS questionnaire shows that psychological violence is the most common form of domestic violence among pregnant women.
Conclusion:
In conclusion, abuse of pregnant women in Iran has increased slightly compared to studies conducted in the years leading up to the Covid-91 pandemic. There was also no significant change compared to other countries investigating IPV against pregnant women during Covid-19 illness.
Assessment of Biological and Chemical Exogenous Elicitors in Inducing Plant Systemic Resistance Against Southern Corn Leaf Blight Disease (Bipolaris maydis) and Its Role in Enhancing Corn Growth and Yield
Authors: Mirsam Hishar , Kalqutny Septian Hary , Suriani Suriani , Aqil Muhammad , Nurgaha Yudhistira , Azrai Muhammad 
Published: October 2023

Abstract

One of the alternative control efforts for Southern corn leaf blight (SCLB) disease is using biological agents and certain chemicals as elicitors to induce systemic resistance through increasing secondary metabolites. This study aims to evaluate several types of biological and chemical exogenous elicitors in inducing plant systemic resistance to SCLB disease caused by Bipolaris maydis and their effect on corn growth and yield. Testing was carried out under field conditions with planting spreader rows as inoculum source plants which were planted around the experimental block. This experiment was set up in a randomized block design consisting of eight elicitor treatments, one synthetic fungicide as a control (-), and sterile distilled water as control (+). AUDPC analysis based on disease severity showed that B. cereus strain J6, Chitin, and Chitosan could significantly suppress the SCLB disease progression in the field with the lowest AUDPC values, namely 1230, 1255, and 1255, respectively, and the highest protection index values of 30.31, 28.90, and 30.88%, respectively. Suppression of the SCLB disease progression was related to increasing plant resistance levels through increasing protein and phenolic content. Correlation analysis showed that B. cereus strain J6, Chitin, and Chitosan had a very strong positive correlation with the protection index value. Besides inducing plant resistance, elicitor treatments significantly affected maximum growth potential and plant height variables. Elicitor materials play a beneficial role in protecting corn occurrence by activating the induced systemic resistance system and inducing plant growth.
Hyperconfined Bio-Inspired Polymers in Integrative Flow-Through Systems for Highly Selective Removal of Heavy Metal Ions
Authors: Tanaka Motomu , Nakahata Masaki , Sumiya Ai , Ikemoto Yuka , Nakamura Takashi , Dudin Anastasia , Schwieger Julius , Kaufmann Stefan , Yamamoto Akihisa , Sakai Shinji 
Published: October 2023

Abstract

Access to clean water, hygiene, and sanitation is becoming an increasingly pressing global demand, particularly owing to rapid population growth and urbanization. “Phytoremediation” utilizes a highly conserved phytochelatin in plants, which captures hazardous heavy metal ions from aquatic environments and sequesters them in vacuoles. Herein, we report the design of phytochelatin-inspired copolymers containing carboxylate and thiolate moieties. Titration calorimetry results indicate that the coexistence of both moieties is essential for the excellent Cd2+ ion-capturing capacity of the copolymers. The obtained dissociation constant, KD ~ 1 nM for Cd2+ ion, is four-to-five orders of magnitude higher than that for peptides mimicking the sequence of endogenous phytochelatin. Furthermore, infrared and nuclear magnetic resonance spectroscopy results unravel the mechanism underlying complex formation at the molecular level. The grafting of 0.1 g bio-inspired copolymers onto silica microparticles and cellulose membranes helps concentrate the copolymer-coated microparticles in ≈ 3 mL volume to remove Cd2+ ions from 0.3 L of water within 1 h to the drinking water level (< 0.03 µM). The obtained results suggest that hyperconfinement of bio-inspired polymers in flow-through systems can be applied for the highly selective removal of harmful contaminants from the environmental water.
Aberrant expression of C1q, IL-6 and β-catenin in class VI lupus nephritis
Authors: Xue Jing , Min Yu , Zhu Zeqin , Jia Yuanyuan , Chi Shuhong , Chen Juan 
Published: October 2023

Abstract
Background:
complement component C1q, interleukin-6 (IL-6) and β-catenin have been implicated in the pathogenesis of lupus nephritis (LN). However, their correlation with the pathological progression and type of LN remain unclear.
Methods:
the concentrations of C1q, IL-6 and β-catenin were evaluated in plasma, urine and kidney tissues in LN patients, non-LN systemic lupus erythematosus (SLEn) patients, and healthy cohorts, as well as C57BL/6, IL-6-/-, MRL-Fas/lpr and MRL-Fas/lprIL-6-/- mice.
Results:
more abundant plasma C1q, IL-6 and urine C1q proteins were determined in LN and SLEn patients compared to healthy cohorts. Of note, the concentration of IL-6 and β-catenin in both plasma and urine, and plasma C1q was even higher in LN patients relative to SLEn subjects. Moreover, positive correlations were determined for C1q and β-catenin proteins between plasma and urine in LN patients. Of importance, both plasma and urine β-catenin, and urine IL-6 were significantly increased in patients with class VI LN patients relative to those who suffered from class I LN. Immunohistochemical study further uncovered that the abundant IL-6 and β-catenin proteins were deposited in both renal glomeruli and tubules, while the C1q was only found in renal glomeruli of patients with class IV LN. Consistent with the clinical findings, experimental studies in MRL-Fas/lprIL-6-/- mice also showed a decreased β-catenin in urine, C1q and β-catenin in kidney tissues of MRL-Fas/lprIL-6-/- mice compared with MRL-Fas/lpr mice. Interestingly, mice with deficiency of IL-6 exhibited less degrees of proteinuria and histological lesions, and reduced serum anti-double-stranded DNA (anti-dsDNA) antibody and sizes of spleen and inguinal node, as compared with MRL-Fas/lpr and C57/BL6 control mice.
Conclusions:
these data suggest a strong correlation among IL-6, C1q and β-catenin in the pathogenesis of type VI LN in SLE patients, indicating that they may be valuable biomarkers for nephrologists to guide treatment and predict prognosis among these patients.
Activation of P2X7R inhibits proliferation and promotes the migration and differentiation of Schwann cells
Authors: Su Wenfeng , He Xiaowen , Lin Zhihao , Xu Jinghui , Shangguan Jianghong , Wei Zhongya , Zhao Yayu , Xing Lingyan , Gu Yun , Chen Gang 
Published: October 2023

Abstract

In the vertebrate nervous system, myelination of nerve fibers is crucial for the rapid propagation of action potentials through saltatory conduction. Schwann cells—the main glial cells and myelinating cells of the peripheral nervous system—play a vital role in the process of nerve fiber myelination. A large amount of ATP is secreted in response to injury during the repair of peripheral nerve injuries. This ATP release subsequently the dedifferentiation of the myelinating Schwann cells into repair cells, which is necessary for the regeneration of axons. Subsequently, to restore nerve function, these repair cells redifferentiate into myelinating Schwann cells. Except for P2X4R, purine receptors such as P2X7R also play a significant role in this process. In the current study, decreased expression of P2X7R was observed immediately after sciatic nerve injury, followed by a gradual increase to the normal level of P2X7R expression. In vivo experiments showed that the activation of P2X7R using an agonist injection promoted nerve regeneration, whereas the administration of P2X7R antagonists inhibited nerve regeneration. Further, in vitro experiments supported these findings and demonstrated that P2X7R activation inhibited the proliferation of Schwann cells, but it promoted the migration and differentiation of the Schwann cells. In the current study, it was proposed that the manipulation of P2X7R expression in Schwann cells after nerve injury could be effective in facilitating nerve regrowth and remyelination. This finding would provide novel ideas and strategies for treatment programs in the future aimed at promoting nerve repair and functional recovery.
Ultrasound-aided extraction of bioactive ingredients from Vitis vinifera seeds using optimized conditions of Central Composite Design of RSM, ANFIS modeling, and Machine Learning algorithm
Authors: Kunjiappan Selvaraj , Ramasamy Lokesh Kumar , Kannan Suthendran , Pavadai Parasuraman , Theivendren Panneerselvam , Palanisamy Ponnusamy 
Published: October 2023

Abstract
Grape seeds are a cost-effective source of antioxidant and potential therapeutic compounds in the form of polyphenols. Therapeutic important polyphenols were completely extracted from grape seeds using an ultrasound-aided extraction technique and examined the antioxidant properties. The present study aimed to determine the optimized condition and green process for maximum extraction of polyphenols from grape seeds through RSM (response surface methodology), ANFIS (adaptive neuro-fuzzy inference system), and machine learning (ML) algorithm models. Effect of five independent variables and their ranges, particle size (X1: 0.5-1 mm), methanol concentration (X2: 60-70% in distilled water), ultrasound exposure time (X3:18-28 min), temperature (X4: 35-45 °C), and ultrasound intensity (X5: 65-75 W cm-2) at five levels (-2, -1, 0, +1, and +2) concerning dependent variables, total phenolic contents (y1), total flavonoid contents (y2), %DPPH*sc (y3), %ABTS*sc (y4) and FRAP (y5) were selected. The optimized condition was observed at X1= 0.155 mm, X2= 65% methanol in water, X3= 23 min ultrasound exposure time, X4= 40 °C, and X5=70 W cm-2 ultrasound intensity. Under this situation, the optimal yields of TPC, TFC, and antioxidant scavenging potential were achieved to be 670.32 mg GAE/g, 451.45 mg RE/g, 81.23% DPPH*sc, 77.39% ABTS*sc and 71.55 μg mol (Fe(II))/g FRAP. This optimal condition yielded equal experimental and expected values. A well-fitted quadratic model was recommended. Furthermore, the validated extraction parameters were optimized and compared using the ANFIS and random forest regressor-ML algorithm. Additionally, GC-MS and LC-MS analyses were performed to find the existence of the bioactive compounds in the optimized extract.