bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are dysfunctional attitudes elevated and linked to mood in bipolar disorder? A systematic review and meta‐analysis
Authors: Woods Chloe , Richardson Thomas , Palmer‐Cooper Emma 
Published: October 2023

AbstractObjectivesDysfunctional attitudes (DA) are higher in depression; however, less is understood about their role in bipolar disorder (BD). This paper aimed to explore the presence of DA in BD in comparison to clinical and non‐clinical groups. Also explored were the associations between DA and mood states of depression, mania or euthymia in BD.MethodsA systematic review and meta‐analysis were conducted. A total of 47 articles were included in the systematic review of which 23 were included in the meta‐analysis. The quality of each study was rated.ResultsThe meta‐analysis showed significantly higher DA in BD than healthy controls (d = .70). However, no difference was observed between BD and unipolar participants (d = −.16). When reviewing mood state within BD, a significant mean difference was found between DA scores for euthymic and depressed participants (d = −.71), with those who were depressed scoring higher. Three studies found that psychological therapies significantly reduce DA in BD (d = −.38).ConclusionsThese findings imply not only that DA are both a characteristic of BD that is not as prevalent in healthy populations but also that a depressed mood state is associated with increased severity. This implies that DA could possibly go ‘offline’ when mood symptoms are not present. Psychological therapies appear to reduce DA in BD. Implications for future research as well as practice‐based implications are expanded on in the discussion.
Stratified management based on surface antibody for the prevention of hepatitis B virus reactivation in lymphoma patients
Authors: Liu Hailing , He Zhen , Gui Renfu , Guo Jingjing , Chen Lvwen , Zhong Miao , Li Jianyong , Cao Lei , Fan Lei 
Published: October 2023

SummaryThis study aimed to investigate a stratified approach based on hepatitis B virus (HBV) surface antibody (anti‐HBs) for managing HBV reactivation (HBVr) in lymphoma patients with serological protection against HBV. A retrospective analysis was conducted on 209 lymphoma patients with a baseline anti‐HBs titre of ≥10 iu/L, who were either positive or negative for HBV core antibody (anti‐HBc). The results revealed that 15.7% of patients lost serological protection following 6‐month anti‐lymphoma therapy. With a median follow‐up of 28.1 months, the cumulative rates of HBVr at 6 months, 2 years and 4 years were 2.9%, 4.7% and 6.3% respectively. Without intervention, the overall rate of reactivation was 2.0% for patients with isolated anti‐HBs and 10.5% for those with positive anti‐HBs and anti‐HBc. To identify patients at high risk of losing seroprotection and susceptible to HBVr, a predictive model was developed. The high‐risk group had significantly higher rates of serological protection loss (27.8% vs. 2.2%) and cumulative incidence of HBVr (22.0% vs. 0%) compared to the low‐risk group. Overall, this study highlights the risk of HBVr in lymphoma patients with positive anti‐HBs, with or without positive anti‐HBc, and recommends periodic monitoring for low‐risk patients and early intervention for high‐risk patients.
High recurrence rate of eczema herpeticum in moderate/severe atopic dermatitis –TREATgermany registry analysis
Authors: Traidl Stephan , Heinrich Luise , Siegels Doreen , Rösner Lennart , Haufe Eva , Harder Inken , Abraham Susanne , Ertner Konstantin , Kleinheinz Andreas , Schäkel Knut , Wollenberg Andreas , Effendy Isaak , Quist Sven , Asmussen Andrea , Wildberger Julia , Weisshaar Elke , Wiemers Franka , Brücher Jens‐Joachim , Weidinger Stephan , Schmitt Jochen , Werfel Thomas ,   the TREATgermany Study Group
Published: October 2023

SummaryBackgroundEczema herpeticum (EH) is a disseminated skin infection caused by herpes simplex virus in atopic dermatitis (AD) patients. The frequency of EH and the clinical features of EH patients have not yet been investigated in a larger cohort.MethodsWe sought to investigate the TREATgermany cohort, a multicenter, non‐interventional clinical registry of moderately to severely affected AD patients in Germany. Baseline characteristics of patients included between December 2017 and April 2021 were compared between patients without, single, and multiple EH.ResultsOf the 893 patients, 195 (21.8%) had at least one EH. Of the 195 patients with EH, 107 had multiple EH (54.9%), representing 12.0% of the total study population. While there were no differences in demographic characteristics, previous treatment, and disease scores at enrollment (itch, IGA, oSCORAD, EASI), patients with EH had more frequent atopic comorbidities and sensitizations to house dust mite, food, and mold.DiscussionTREATgermany registry data suggest a high prevalence and recurrence rate of EH, while there appears to be no specific clinical phenotype, besides an increase in allergies, to identify EH patients in the daily routine.
Effects of organic carbon and clay contents on structure‐related properties of arable soils with high clay content
Authors: Soinne Helena , Keskinen Riikka , Tähtikarhu Mika , Kuva Jukka , Hyväluoma Jari 
Published: October 2023

AbstractUnderstanding of factors governing soil structural features is necessary for managing key processes affecting crop productivity and environmental impacts of agriculture, for example, soil water balance, aeration, and root penetration. Organic matter is known to act as a major binding agent in soil aggregation and thus constitutes a central pillar in soil structure formation. However, knowledge of the structural role of organic matter or carbon (OC) in soils highly rich in clay‐sized particles (<0.002 mm) is limited. In this study, the effects of clay and OC contents on aggregate stability, water holding capacity, near‐saturated hydraulic conductivity, total porosity, and pore size distribution were assessed in cultivated fields with high clay content located in private crop production farms in southern Finland. Significant positive correlations were found between OC content and proportion of water stable aggregates and specific pore sizes from the range of 30 μm up to 1 mm diameter determined by image analysis. Porosities on a smaller size range derived from water retention measurements likewise showed a positive correlation with OC in <0.2 μm sizes. On the range of 0.2–1 μm, a negative relationship was observed, which induced a negative effect of OC on soil plant available water reserves. In line with the positive correlation between OC and larger soil pores, free water, representing the amount of water that can be drained by gravity, exhibited a positive relationship with OC suggesting that OC content can enhance aeration of soils with high clay content. Compared to OC, clay content tended to have an adverse effect on soil structural properties. Clay correlated negatively with pores larger than 30 μm, free water content, and extrapolated field saturated hydraulic conductivity. Further, our imaging results showed how saturated hydraulic conductivity was controlled by pore morphology, and there was a power law relationship between the conductivity and critical pore diameter. in agreement with the percolation theory. Overall, the structural impacts and hydrological implications of OC and clay in heavy clay soils vary by pore size ranges and their emergent practical impacts are thus not straightforward.
Did Martin Luther suffer from vestibular migraine?
Authors: Evers Stefan 
Published: October 2023

AbstractMartin Luther (1483–1546) reported attacks of headache and of vertigo in his letters and in his lectures. The symptomatology of his headache attacks fulfilled, at least in part, the diagnostic semiological criteria of migraine. However, because we cannot be sure about the time pattern and the exclusion of other disorders that might explain the headache, the diagnosis of migraine is not final. The vertigo attacks sometimes fulfilled the criteria of Ménière's disease. Vertigo also occurred together with headache attacks fulfilling the International Classification of Headache Disorders, 3rd edition criteria for vestibular migraine; however, we do not know exactly the pattern of attack frequency and duration. In summary, it is possible that Martin Luther suffered from attacks of vestibular migraine and had in addition a comorbidity of migraine and Ménière's disease.
The 33rd International Conference on Arabidopsis Research (ICAR2023)
Authors: Ueda Minoru , Higashiyama Tetsuya , Sugimoto Keiko , Mochida Keiichi , Nakajima Keiji , Hayashi Makoto , Okamoto Masanori , Nakamura Yuki , Seki Motoaki 
Published: October 2023

AbstractThe 33rd International Conference on Arabidopsis Research (ICAR2023) was held at Makuhari Messe International Conference Hall in Chiba prefecture from June 5 to 9, 2023. This annual conference, which rotates among hosts in North America, Asia–Oceania, and Europe, covers the full range of plant biology research involving Arabidopsis and other plant species. The conference hosted more than 1200 participants, including approximately 800 international attendees from 42 countries (or regions), and featured about 900 oral and poster presentations. Reflecting the conference theme, “Arabidopsis for Sustainable Development Goals (SDGs),” there were numerous exemplary presentations regarding basic plant science using Arabidopsis and translational research conducted to achieve SDGs by exploiting the knowledge gained from Arabidopsis to improve crop production. The conference concluded on a high note, with more than 99% of survey respondents expressing their general satisfaction with ICAR2023. This report aims to summarize the organization, objectives, and outcomes of the conference.
Exploring the effect of the Russian–Ukrainian conflict on MENA firms: Does the monetary policy play a role?
Authors: Sami Mina 
Published: October 2023

AbstractThis paper explores the effect of the Russian–Ukrainian conflict on the firms operating in the Middle East and North African (MENA) countries, focusing on how different sectors of the economy have responded. The empirical methodology utilizes firm‐level data from MENA countries, employing fixed effect and instrumental variable estimations to control for the potential endogeneity of casualties in the war and firm dynamics. The results of this study reveal that (1) an increase of 1% in the hostility of the Russian–Ukrainian war corresponds to a 0.13% decrease in the market cap of MENA firms. (2) This effect is more pronounced among highly indebted firms, conducting business solely within the domestic market, and operating on a small scale. (3) The monetary policy is vital in mitigating the effect of the conflict on firms.This study has two main contributions. First, it empirically assesses how firms operating in the MENA region respond to geopolitical events, highlighting differences in responses between firms and sectors. Second, this paper serves as guidelines for governments to face the challenges raised by wars. In particular, the paper shows the relevance of sector‐specific policy responses based on the extent to which each sector is affected by geopolitical events.
NON‐IMMUNOLOGICAL RELEASE OF SLOW‐REACTING SUBSTANCE FROM GUINEA‐PIG LUNGS
Authors: PIPER PRISCILLA J. , SEALE J.P. 
Published: October 2023

During incubation with calcium ionophore A23187, sensitized and unsensitized guinea‐pig chopped lung released a slow‐reacting substance (SRS) and histamine.
SRS possessed many characteristics of slow‐reacting substance of anaphylaxis (SRS‐A). It was inactivated by arylsulphatase, antagonized by FPL55712 (1 μg/ml) and more stable in alkali than acid. Furthermore, it behaved like SRS‐A by stimulating arachidonic acid metabolism in guinea‐pig isolated perfused lungs.
Maximal ionophore generation of SRS in sensitized lung was greater than maximal anaphylactic generation of SRS‐A but the release of histamine was not significantly different. Simultaneous challenge with antigen and ionophore produced more SRS‐like or SRS‐A‐like activity than either stimulus alone.
These results have shown a non‐immunological release from guinea‐pig lung of SRS which was similar (or possibly identical) to SRS‐A. It is suggested that in addition to mast cells, other cell types may be involved.
SOME PROPERTIES OF 5‐HYDROXYTRYPTAMINE RECEPTORS IN THE HINDQUARTERS OF THE RAT
Authors: COOPER MARIE , WYLLIE JOHN H. 
Published: October 2023

The rat hindquarter preparation, as described, responds with reproducible vasoconstriction to noradrenaline and tryptamines.
The receptors involved in these responses are distinct.
Evidence of heterogeneity of tryptamine receptors was not obtained.
The 5‐hydroxytryptamine (5‐HT) antagonists, methysergide and cyproheptadine, although very potent, displayed antagonism of a non‐competitive type whereas a series of phenothiazines and phentolamine displayed competitive antagonism against 5‐HT.
For the phenothiazines the order of increasing potency was promazine < chlorpromazine < triflupromazine.
α2‐ADRENOCEPTORS MEDIATE CLONIDINE‐INDUCED SEDATION IN THE RAT
Authors: DREW G.M. , GOWER ALMA J. , MARRIOTT A.S. 
Published: October 2023

The central α‐adrenoceptors responsible for mediating clonidine‐induced sedation in rats have been characterized according to their sensitivity to α‐adrenoceptor agonists and antagonists.
Clonidine, injected intraperitoneally or intracerebroventricularly, caused dose‐dependent sedation, both in terms of a reduction in the time that rats could remain on an accelerating rotarod and in terms of overt sedation assessed visually. Following intracerebroventricular injection, xylazine, naphazoline and methoxamine, but not phenylephrine, produced similar effects.
The sedation caused by intraperitoneal injection of clonidine was antagonized by intracerebroventricularly injected phentolamine, yohimbine, piperoxan and tolazoline but not by labetalol, thymoxamine or prazosin.
The relative potencies of the agonists in causing sedation and of the antagonists in inhibiting the sedative effect of clonidine clearly demonstrated that the central α‐adrenoceptors mediating clonidine‐induced sedation are the same as the peripheral presynaptic α2‐adrenoceptors.
All the α‐adrenoceptor agonists caused hypothermia after intracerebroventricular injection, but their order of potency was different from that in producing sedation. The hypothermic effect of intraperitoneally injected clonidine was little affected by any of the antagonists administered intracerebroventricularly. No conclusions could be drawn concerning the type of receptor responsible for mediating hypothermia.
A hypotensive protocol of inspiratory muscle strength training: Systematic review and meta‐analysis with trial sequential analysis
Authors: Li Wenjing , Zhu Xiaoping , Wang Xinai , Liu Hao , Liu Jingying , Xiao Hongling , Dong Liang , Wang Chenqi , Wu Yaxuan 
Published: October 2023

AbstractThe aim of this study was to evaluate the hypotensive effect and optimal protocol of inspiratory muscle resistance training (IMST). Randomized controlled trials using IMST to lower blood pressure (BP) were retrieved from 12 databases as of July 2022. A meta‐analysis of BP and heart rate variability (HRV) was performed and a trial sequence analysis was performed using trial sequential analysis (TSA) software. Twelve articles (n = 386 participants) from five countries were included, with a mean quality score of 5.83. IMST achieved significant results in reducing systolic, diastolic, and mean arterial pressure (−7.93 [−12.08, −3.78]; −3.80 [−6.08, −1.53]; −4.90 [−13.76, 3.96]). Furthermore, TSA has shown that the findings for systolic and diastolic BP are conclusive. Finally, considerable variation remained between studies when analyzing HRV. The overall hypotensive effect of IMST was demonstrated by the TSA and was well tolerated in different populations. Of these, two interventions, high resistance or low resistance combined with slow breathing, showed the best efficacy under an 8‐week exercise intervention. In addition, the process of lowering BP by modulating sympathetic vagal activity has not been further confirmed in this study. Future long‐term interventions, especially those over 3 months, are needed to observe the prolonged antihypertensive effects and modulatory mechanisms; controlling for variables such as respiratory rate and executing more rigorous studies to further explore antihypertensive options.
The role of maternal hormones in regulating autonomic functions during pregnancy
Authors: Georgescu T. 
Published: October 2023

AbstractOffspring development relies on numerous physiological changes that occur in a mother's body, with hormones driving many of these adaptations. Amongst these, the physiological functions controlled by the autonomic nervous system are required for the mother to survive and are adjusted to meet the demands of the growing foetus and to ensure a successful birth. The hormones oestrogen, progesterone, and lactogenic hormones rise significantly during pregnancy, suggesting they may also play a role in regulating the maternal adaptations linked to autonomic nervous system functions, including respiratory, cardiovascular, and thermoregulatory functions. Indeed, expression of pregnancy hormone receptors spans multiple brain regions known to regulate these physiological functions. This review examines how respiratory, cardiovascular, and thermoregulatory functions are controlled by these pregnancy hormones by focusing on their action on central nervous system circuits. Inadequate adaptations in these systems during pregnancy can give rise to several pregnancy complications, highlighting the importance in understanding the mechanistic underpinnings of these changes and potentially identifying ways to treat pregnancy‐associated afflictions using hormones.
Is proximity better? The geographical proximity of financial resources and green innovation
Authors: Sheng Jichuan , Ding Rui 
Published: October 2023

AbstractThe agglomeration of financial resources is generally considered to encourage business practices that promote green innovation. In addition, green innovation is also subject to firms' location and may exhibit significant spatial effects. However, most studies failed to consider the complex association between financial resources and green innovation from the lens of geographical proximity. This paper scrutinizes the influence of geographical proximity of financial resources on green innovation with the case of Chinese listed firms. It critically examines the role of trade‐offs between competitive and substitution effects triggered by geographical proximity in this complex relationship. The findings demonstrate that the geographical proximity of financial resources affects firms' trade‐offs between competitive and substitution effects, changing their green innovation activities. In addition, green innovation and distance to financial centers have an inverted U‐shaped association, suggesting an optimal location between the firm and financial centers conducive to green innovation. Finally, internal ownership reinforces the effect of geographical proximity of financial resources on green innovation, while external environmental regulation weakens this effect. Therefore, this paper extends the existing green innovation theory from the lens of geographic proximity. This can help us better understand the influence of geographic proximity of financial resources on green innovation.
Rapid evolution of novel biotic interactions in the UK Brown Argus butterfly uses genomic variation from across its geographical range
Authors: de Jong Maaike , van Rensburg Alexandra Jansen , Whiteford Samuel , Yung Carl J. , Beaumont Mark , Jiggins Chris , Bridle Jon 
Published: October 2023

AbstractUnderstanding the rate and extent to which populations can adapt to novel environments at their ecological margins is fundamental to predicting the persistence of biological communities during ongoing and rapid global change. Recent range expansion in response to climate change in the UK butterfly Aricia agestis is associated with the evolution of novel interactions with a larval food plant, and the loss of its ability to use an ancestral host species. Using ddRAD analysis of 61,210 variable SNPs from 261 females from throughout the UK range of this species, we identify genomic regions at multiple chromosomes that are associated with evolutionary responses, and their association with demographic history and ecological variation. Gene flow appears widespread throughout the range, despite the apparently fragmented nature of the habitats used by this species. Patterns of haplotype variation between selected and neutral genomic regions suggest that evolution associated with climate adaptation is polygenic, resulting from the independent spread of alleles throughout the established range of this species, rather than the colonization of pre‐adapted genotypes from coastal populations. These data suggest that rapid responses to climate change do not depend on the availability of pre‐adapted genotypes. Instead, the evolution of novel forms of biotic interaction in A. agestis has occurred during range expansion, through the assembly of novel genotypes from alleles from multiple localities.
Transcription factor CreA is involved in the inverse regulation of biofilm formation and asexual development through distinct pathways in Aspergillus fumigatus
Authors: Liu Shuai , Lu Xiaoyan , Dai Mengyao , Zhang Shizhu 
Published: October 2023

AbstractThe exopolysaccharide galactosaminogalactan (GAG) contributes to biofilm formation and virulence in the pathogenic fungus Aspergillus fumigatus. Increasing evidence indicates that GAG production is inversely linked with asexual development. However, the mechanisms underlying this regulatory relationship are unclear. In this study, we found that the dysfunction of CreA, a conserved transcription factor involved in carbon catabolite repression in many fungal species, causes abnormal asexual development (conidiation) under liquid‐submerged culture conditions specifically in the presence of glucose. The loss of creA decreased GAG production independent of carbon sources. Furthermore, CreA contributed to asexual development and GAG production via distinct pathways. CreA promoted A. fumigatus GAG production by positively regulating GAG biosynthetic genes (uge3 and agd3). CreA suppressed asexual development in glucose liquid‐submerged culture conditions via central conidiation genes (brlA, abaA, and wetA) and their upstream activators (flbC and flbD). Restoration of brlA expression to the wild‐type level by flbC or flbD deletion abolished the abnormal submerged conidiation in the creA null mutant but did not restore GAG production. The C‐terminal region of CreA was crucial for the suppression of asexual development, and the repressive domain contributed to GAG production. Overall, CreA is involved in GAG production and asexual development in an inverse manner.