bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unravelling Intervertebral Disc Creep behaviour through Mathematical models. An in-vitro Study
Authors: Sciortino Vincenza , Jansen Jan Ulrich , Cerniglia Donatella , Ingrassia Tommaso , Wilke Hans-Joachim 
Published: November 2023

Abstract
The intervertebral disc (IVD) is a complex biological structure due to its viscoelastic nature. The IVD ensures the spine strength, stability, mobility, and flexibility. This is enabled by the complex relationship between external mechanical loads and cellular response, more specifically it is related to its mechanobiology. Nevertheless, the viscoelastic properties and mechanobiology of the IVD are not fully understood. Hence, new insights are researched by investigating the IVD biomechanical response to long-term loads, which is critical since it influences hydration, nutrients, and water transport. In this paper an in-vitro study was performed on seven human lumbar spine specimens (L4-5), to assess if the classical rheological models and Nutting's power law can model the intermediate characteristics between solid and fluid of the IVD. Creep tests were conducted by applying a static compression load of 500 N for 15 minutes. A correlation analysis was done (Pearson, 𝑝 < 0.05) between the model parameters and the maximum value of Disc Height Reduction (DHR), followed by a linear regression analysis. As conclusive remarks, through this work it has been possible to underline how a mathematical modelling of the IVD long-term mechanical behaviour is of extreme importance to understand the mechanism of deformation and reduction in disc height during the day and restoration in height during the night. Future goals will be to identify the relationship between the macroscopic and cellular mechanics of the IVD, and to further understand the entire mechanism underlying disc degeneration and ageing.
Comparative Study of Solvent Effect for tryptophan Oxidation by Different Oxidants
Authors: PERIYASAMY S. K. 
Published: November 2023

Abstract
Quinaldinium fluorochromate (QnFC), imidazolium fluorochromate (IFC), quinoxalinium dichromate (QxDC), imidazolium chlorochromate (ICC), and quinaldinium chlorochromate (QnCC) have all performed tryptophan oxidation at 308K using various solvents, including dimethyl sulphoxide (DMSO), dimethyl formamide (DMF),acetone, dichloromethane (DCM) and 1,2-dichloroethane (DCE). This has led to the formation of the corresponding indole-3-acetaldehyde. We examined the solvent effect using the Technique for Order of Preference by Similarity to Ideal Solution(TOPSIS) method, and the solvent performance score for the reaction revealed the following order: DMSO > DMF > DCE > DCM > ACETONE. Corresponding indole-3-acetaldehyde were formed as a result of the oxidation process with all of the oxidants.
Effect of regulating Piezo2 expression in DRG on core phenotype, S1 and mPFC neuron functions in ASD mouse model
Authors: Zhai Jinhe , Hao Haiying , Xu Zihan , Tomoda Akemi , Zhang Xinyi , Wang Xinxin , Cao Xuan , Li Dongxin , Li Xiaoxue , Fan Lili , Wang Jia , Wu Lijie 
Published: November 2023

Abstract
Background
Tactile overreaction (TOR) in the symptoms of autism spectrum disorder (ASD) has attracted attention because of its high incidence and potential influence on the core phenotype. However, the possible causes of TOR are unclear. Piezo2 is a mechanically gated ion channel that mainly mediates low-threshold touch. But there is no research to prove whether it is related to the tactile symptoms of ASD. In this study, we investigated the expression of Piezo2 in peripheral nervous system of BTBR in ASD model mice, and whether Piezo2 inhibitor GsMTx4 can alleviate the symptoms of ASD such as TOR and social injury, and evaluated the effects on the function of neurons in primary somatosensory cortex (S1) and medial prefrontal cortex (mPFC). At the same time, we further explored whether soft touch stimulation, a non-invasive intervention method, can achieve similar effects as GsMTx4 administration.
Results
Piezo2 was overexpressed in the dorsal root ganglion (DRG) of BTBR mice than that in wild-type C57BL/6(C57) mice, accompanied by TOR of hairless skin on the sole. However, this overexpression was not found in the trigeminal ganglion (TG), and no obvious abnormal response of the face to stimulation was observed. Starting from the 28th day after BTBR was born, administration of GsMTx4 for 3 days alleviated the TOR, social deficits, and repetitive behavior in BTBR. Surprisingly, neuron overactivation in the S1 and mPFC during social activities reduced, while dendritic spine density in mPFC increased. We further found that chronic soft touch also could improve behavior and central nervous system function, accompanied by the decrease of Piezo2 overexpression in the DRG of BTBR.
Conclusion
GsMTx4 administration and soft tactile stimulation can effectively inhibit the over-expression of Piezo2 in DRG of BTBR mice, alleviate a series of ASD symptoms such as TOR and social defects, and improve the functions of S1 and mPFC cortical neurons.
The homeobox family gene signature predicts the prognosis of osteosarcoma and correlates with immune invasion
Authors: 刘 文炟 , Xia Kezhou , Huang Xinghan , Wei Zhun , Wei Zicheng , Guo Weichun 
Published: November 2023

Abstract
Osteosarcoma is the most common aggressive bone cancer. In recent years, it has been found that many homeobox family genes are involved in the occurrence, development, and invasion of tumors. But what role does the HOX family play in osteosarcoma remain unclear. To investigate the role of the HOX family in osteosarcoma and to develop a risk prognostic model, we collected osteosarcoma patients’ information in The Cancer Genome Atlas (TCGA) cohort. We then used LASSO regression analysis and multivariate COX regression analysis to finalize four genes (HOXA1, HOXA5, HOXA6, HOXA13) to build a risk-prognostic model. Osteosarcoma patients were divided into high- and low-risk groups. The prognosis of the low-risk group was significantly better than that of the high-risk group, and the ROC curve could well simulate the survival time of patients. We then included the age and gender of the patients to construct a nomogram, which can better predict the overall survival time of the patients. Differences in gene function between the two risk groups were more concentrated in immune-related pathways, and GSEA analysis also suggested that the immune-enrichment pathway played an important role between the two groups. ssGSEA indicated that the immune cell content and immune function in the high-risk group were relatively deficient. Finally, HOXA1 was selected for in vitro and in vivo experiments to verify. In summary, we constructed a risk prognosis model based on HOX family genes and identified HOXA1 for verification. This model has good accuracy and universality, which can improve the early diagnosis rate and predict the prognosis of osteosarcoma patients and can help clinicians make decisions and individualized treatment.
Finding Solutions to Ecological and Environmental Crisis with a New Ethics
Authors: Pechočiaková Svitačová Eva 
Published: November 2023

Ecological and environmental crises are related to the development of an anthropocentric human culture. They threaten the values on which human life and development on Earth depend, and therefore the need for a new ethic arises. The aim of this paper, which is based on a qualitative analysis of theoretical sources, is to highlight the gravity of these crises and to present a 'new ethics', which is referred to as the ethics of the future, the ethics of responsibility for the future or the ethics of sustainability. We draw on the work of H. Jonas and other thinkers who point out that the traditional ethics, which is also referred to as anthropocentric, is no longer sufficient in today's world. It cannot contribute to solving these crises. We argue in favour of a 'new ethics' that takes into account the distant future and relies on a new dimension of responsibility, but also of justice. It urges people to be able to take responsibility for the consequences of their actions and not to endanger the survival of humanity on the planet and also of all life. With this in mind, it should also play a part in shaping their moral character.
The Synergistic Effect of Curcumin and Piperine Nanoparticles on Methamphetamine-induced Neurotoxicity, Oxidative Stress, and Memory Impairments in Mice Brain
Authors: Ebrahimnejad Pedram , Ghazvini Hamed , Hasanjani Parisa , Saberi-Hasanabadi Parisa , Akhtari Javad , Mohammadi Hamidreza 
Published: November 2023

Background:
Methamphetamine (METH) is a highly addictive neural stimulant that severely affects the CNS and can induce oxidative damage. Piperine and curcumin are active constituents that have numerous properties, including antioxidant, anti-inflammatory, and neuroprotective

Objective:
In this study, the synergistic effect of piperine and curcumin nanoparticles was investigated on the acute doses of METH-induced neurotoxicity in mice brains.

Methods:
METH (6 mg/kg, i.p) was administered to 14 groups of mice and piperine-curcumin nanoparticles at different doses (10, 20, 40 mg/kg and 20, 40 and 60 mg/kg, respectively) were administered. Open field test (OFT) and conditioned place preference (CPP) were used to investigate locomotor activity, anxiety-like behavior, and addictive behavior in mice. Oxidative stress biomarkers
(reactive oxygen species (ROS), protein carbonyl content, lipid peroxidation, glutathione content,
and mitochondrial function were evaluated in isolated brain mitochondria.

Results:
We found that piperine and curcumin nanoparticles significantly decreased hyperlocomotion and anxiety-like behavior in METH-treated mice. Also, METH enhanced CPP whilst piperine
and curcumin nanoparticles suppressed the effect of METH-induced CPP. METH administration
significantly increased ROS, protein carbonyl content, and lipid peroxidation and decreased glutathione content and mitochondrial function in the isolated brain mitochondria. Piperine and curcumin
nanoparticles (at all doses) showed synergistic effects on reducing oxidative damages in a dosedependent manner compared to the METH group.

Conclusion:
In conclusion, combined piperine and curcumin nanoparticles showed greater neuroprotective effects against METH-induced neurotoxicity due to their greater permeability and better antioxidant properties than piperine and curcumin alone
An Emerging Class of Antimicrobial Heterocycles Derived from Natural Sources
Authors: Chaudhary Benu , Patial Babita , Sharma Rajiv , Chawla Anshul 
Published: November 2023

:
An energetic desire to reduce the undesirable effects brought on by synthetic heterocyclic
substances and to combat antimicrobial resistance has led to an increase in curiosity in using natural
antimicrobial agents derived from plants, such as phenolics, catechol, pyrogallol, essential oils, Lchicoric acid, caffeic acid, catechins, coumarin, proanthocyanidins, 4-thiazolidinone, and alkaloids.
The usage of naturally occurring heterocycles against Gram-positive (S. aureus, S. pyogenes, B.
subtilis, A. niger, and B. cereus) and Gram-negative (P. aeruginosa, E. coli, K. pneumonia, P. vulgaris, and S. infantis) bacteria has been the subject of increased investigation in past few decades. This
review targets the use of plant-derived antimicrobials to increase the microbiological safety of food
and the possible antimicrobial activity of nitrogen- and oxygen-based heterocyclic compounds. It is
possible to find novel medications to treat infectious diseases and address the issues brought on by
antibiotic resistance by exploring and utilising the potential of these chemicals. Additional research
is desirable on the toxicological effects and potential additive and/or synergistic antimicrobial actions
in order to maximise the usage of these potential natural antimicrobials in foods.
Gut–Skin Axis: Gut Microbiota as a Link Between Rosacea and Gastrointestinal
Comorbidities
Authors: Arora Navneet , Kumar Ranjeet 
Published: November 2023

Abstract:
Rosacea, a prevalent dermatological condition, is characterized by the clinical manifestations of erythema, papules, and pustules. This paper delves
into the emerging role of the gut-skin axis in Rosacea's pathophysiology. Convincing evidence supports the involvement of gut microbiota in
orchestrating the inflammatory cutaneous response. Its multifaceted etiology is thought to be influenced by genetic susceptibility, alterations in the
neurovascular and immune systems, and altered interactions with the microbiota. Strong connections broaden our understanding of Rosacea,
linking it to neurological conditions like Parkinson's disease and gastrointestinal issues such as Helicobacter pylori infection and small intestinal
bacterial overgrowth (SIBO), supporting the existence of an intricate brain-gut-skin connection. The interplay between these organs' homeostatic
and regulatory systems is increasingly evident. While we have not fully grasped the details of immunological, neuroendocrine, and metabolic
pathways, it is clear they play a part in chronic inflammatory skin conditions like Rosacea. Delving into these intricate pathways promises a
nuanced comprehension of the disease's etiopathogenesis. An in-depth investigation into the roles of dysbiotic microbiota and dysregulated innate
immune responses is imperative to comprehensively fathom Rosacea's pathophysiological landscape. A refined grasp of this condition and the gutskin
axis holds the potential for optimizing therapeutic trajectories. The purpose of this review is to explore potential bacterial indicators of the
disease and to assess whether the gut microbiome makeup of individuals with inflammatory Rosacea differs from that of healthy controls.
Furthermore, it critically assesses and consolidates previously documented alterations in peripheral blood, skin, and gastrointestinal tract
microbiomes within rosacea patients. This review illuminates the intricate dance of microbiota in the context of Rosacea, forging a bridge between
cutting-edge insights and its implications. By synthesizing current knowledge, this review advances our understanding of microbiota-driven
mechanisms in inflammatory Rosacea, paving the way for innovative therapeutic strategies.
A Review on Privacy Protection Techniques in Smart Grid Applications
Authors: Gupta Rakhi , Singh Parminder , Kaur Avinash , Hedabou Mustapha 
Published: November 2023

:
The extensive use of electricity and the increasing number of consumers challenge
matching power consumption with the power generated. Having a traditional way of power generation and distribution, power is also widely fetched through renewable energy sources. So, to
have improved efficiency and reliable means of the power source, to be able to integrate multiple
sources of power generation like PV Cells, Solar Power, and Wind Power into the existing
standards of the power source, precise calculations of the power consumption in the multisource
environment, provision to scale up the smart and electric vehicle and most importantly, to reduce
the carbon emissions, several attempts have been made to convert the traditional grids into smart
grids. A tiny step in the smart grid's development is the smart metering infrastructure, in which
smart meters are deployed through the consumer end. Through smart meters, it is possible to
establish the link, either through wireless media or wired connections, between the consumer and
the grid. Once the smart meters are deployed through the Advanced Metering Infrastructure
(AMI), the meters remain active round the clock, giving a window to hackers. Through this window, utility bill manipulations, payment transaction information, and other significant data can
be accessed by unethical approaches and threaten the consumer's privacy. This review-research
paper discusses various methods presented by distinct authors to address the issues related to
customer privacy protection in the smart grid.
Dionisio Rodríguez Castillo, su aportación a la imprenta en Guadalajara y su labor benéfica por los más necesitados
Authors: Miranda Báez Alba del Carmen 
Published: November 2023

El objetivo general de esta investigación ha sido recopilar información que revelara la labor altruista que realizó Dionisio Rodríguez, un jalisciense que vivió en Guadalajara, Jalisco (México), hacia mediados del siglo XIX. Un hombre ejemplar conocido por sus obras benéficas en pro de los desvalidos, reconocido en el contexto temporal en que vivió, aunque olvidado a través de los años. Hoy en día es valorado como impresor y propagador de las letras, pero también fue una persona que hizo obra benéfica en la ciudad, por lo que dejó huella en quienes lo conocieron.
La información recabada ha permitido mostrar que Rodríguez ayudó a cientos de personas a través de la Escuela de Artes y Oficios, y otras labores de beneficiencia local. Cuando murió, Guadalajara se paralizó. A su velorio acudieron cerca de quince mil personas, cuando en aquellos años la ciudad contaba con alrededor de ochenta mil. Era tal su valoración, que al día siguiente (2 de mayo de 1877) se le nombró benemérito del estado de Jalisco.
Efecto del epoxiconazol en mezclas sobre Puccinia striiformis f. sp. tritici en el cultivo de trigo
Authors: Faberi Ariel Jesus , Erreguerena Ignacio , Clemente Natalia Liliana , Carlón Matías 
Published: November 2023

Los fungicidas son la principal estrategia de manejo de roya estriada por Puccinia striiformis f. sp. tritici en trigo. El objetivo fue evaluar el aporte del epoxiconazol sobre el control de roya estriada. El ensayo se realizó en un lote de trigo (Algarrobo, Don Mario) (37°53'46.70"S; 58°13'16.49"O) bajo diseño en bloques completos aleatorizados, cuatro repeticiones. La unidad experimental consistió en parcelas de 3 x 8 m. Los tratamientos fueron: testigo; 0,45 L.ha-1 pyraclostrobina (P)/ boscalid (B); 0,23 L.ha-1 P/B + 0,75 L.ha-1 epoxiconazol (E); 0,45 L.ha-1 P/B + 0,75 L.ha-1 E y 0,75 L.ha-1 P/B + 0,75 L.ha-1 E, y se aplicaron en Z31 (roya estriada: 35 % incidencia en hoja, 3,3 % severidad). Se determinó incidencia y severidad a los 15, 32, 57 días después de la aplicación (DDA) y el rendimiento. Las variables se analizaron mediante modelos mixtos. La incidencia en hoja bandera y en las tres inferiores fue menor en los tratamientos con epoxiconazol respecto a la doble mezcla PB y al testigo a los 15 y 32 DDA. A los 15, 32 y 57 DDA la severidad en los tratamientos con epoxiconazol fue menor al testigo y al de doble mezcla. Hubo un aporte significativo de 1438 Kg.ha-1 en el rendimiento del tratamiento de doble mezcla. En los tratamientos con epoxiconazol el incremento en el rendimiento fue superior a 4000 Kg.ha-1. Se concluye que la incorporación de epoxiconazol a la mezcla mostró resultados promisorios desde los puntos de vista sanitario y productivo del cultivo.
Ecological imperatives in contemporary Hungarian poetry
Authors: Csehy Zoltán 
Published: November 2023

Abstract
The study reviews from an ecopoetic point of view the tendencies in Hungarian poetry of recent years that emphasise the biopoetic aspects of existence. László Lázár Lövétei’s eclogues, for example, renew the discourse from the perspective of the ancient tradition, while Tamás Korpa and Mátyás Sirokai transform the reader’s mental consciousness by focusing on the plant life, and in doing so, reassess and rethink the concept of being embedded in nature. For example, Gábor Dávid Németh combines the mechanisms of cultural memory, the ecosystems of environmental awareness and the plant metaphor system arising from the organicity of language. Gábor Mezei approaches the question from the perspective of hybridity. Besides blurring the traditional boundaries of body and self, these authors also exploit the subversive, resistant character of ecopoetics, not once asserting the principle of what they call the ecopoetic imperative whose topological, tropological, entropological and ethnological dimensions are worth exploring.
Oligarchic Politics in the Context of a Democratic Rule of Law in Relation to the Principle of Expediency
Authors: Suftyadi Ahmad Rifai , Heniarti Dini Dewi , Nu’man A Harits 
Published: November 2023

Abstract
Indonesia, which is a democratic country, is not necessarily free from the practice of ownership of a handful of groups that influence the course of the National constitution. Oligarchy begins with the fact that extreme material inequality produces extreme political inequality. Although in a democracy, position and access to the political process are interpreted as equal, the enormous wealth in the hands of a small minority creates a significant excess of power in the political sphere for that group. The practice of oligarchic politics in Indonesia has been prominent and widespread since the New Order era. Oligarchy has undermined the philosophical meaning of democracy, which is political power or government run by the people, and for the people. Freedom in the political field certainly does not mean legalizing all means but remains in the corridor as contained in Pancasila as the basic ideology of the Indonesian nation. The good and bad of the law must be measured by the good and bad consequences produced by the application of the law, meaning that legal provisions can be considered good and provide benefits if the consequences resulting from their application are good, maximum happiness, and reduced suffering.
An Overview of Criminal Provisions Responding to Hate Speech in Turkish Law
Authors: Aydın Devrim 
Published: November 2023

Abstract
There are several reports and cases that demonstrate the clear increase of hate speech in Turkey through media and especially on social media against some national and religious minorities, asylum seekers, refugees, and LGBTQ. This was also reported by the European Commission which pointed out that there is no effective prosecution of incitement to hatred, including by the media. In addition hate speech is not clearly regulated, expressions that can be considered hate speech are interpreted sometimes through provisions that regulate the crime of defamation against a person or the crime of defamation against a part of people. Although tidy legislation which defines and regulates hate speech through media, the internet and, social media is not yet available in the Turkish Penal Code. Major provisions that can be associated with hate speech are available in the Turkish Penal Code in a scattered manner. There are also related regulations in the law governing internet broadcasting and the law governing radio and television broadcasting. Expressions that can be considered hate speech are, in some cases interpreted through provisions that regulate the crime of defamation against the person. The most important problem pertains to the fact that hate speech and hate crimes have not been prescribed under a single title in Turkish Law.