bluuebunny/crossref_metadata_2025_split huggingface dataset:
Этникааралық қатынастар және Қазақстанның этникалық саясатының үлгісі: мәселелері және келешегі
Authors: Абдраимов Е.А. , Садыков Т.С. 
Published: October 2023

Қазақстан Республикасы үшін этникалық саясат пен этникааралық қатынастар ерекше маңызға ие. Осы себептен, мақалада этникааралық қатынастарға және Қазақстанның этникалық саясатының үлгісіне талдау жасалған, этникааралық келісім үлгілерінің негізгі аспектілері көрсетілген. Авторлар этникааралық келісім еліміздің саясатының басым бағыттарының және қазақстандық қоғамның негізгі кұндылықтарының бірі ретінде назар аударған. Мақалада демографиялық өзгерістер, этникалық тарих және этностардың мәдениеті, олардың еліміздегі орны жөніндегі зерттеулерге және мәліметтерге салыстырмалы талдау жасалған. Сонымен бірге, мақалада Қазақстан халқы Ассамблеясы этникааралық және мәдениетаралық қатынастар саясатын қамтамасыз ету үшін құрылған институт ретінде қарастырылған.
Repensar la disciplina histórica desde abajo y desde la periferia. El caso chileno frente a los nuevos desafíos
Authors: Alvarado Leyton Matías 
Published: October 2023

Este artículo repiensa las exigencias que atraviesa la disciplina histórica, particularmente aquellas que rodean o se vuelven evidentes desde la Historia Social. Se propone así una lectura de su naturaleza epistemológica, tomando en consideración su desarrollo en el orbe, para luego dar paso a la evolución que esta rama de la disciplina ha tenido en el país. Esto permite arrojar luces respecto a los pasos a seguir para conseguir no solo mejores resultados, sino también investigaciones más comprometidas y empáticas con las problemáticas que actualmente se viven, proponiendo un rol más activo del historiador en sociedad. Dicho esfuerzo cobra mayor sentido al considerar el creciente hermetismo de las últimas décadas en el cual se ha ensimismado la disciplina histórica, relegada incluso en la academia, y alejada de la población, limitada, muchas veces, a una crítica intranscendente al mundo que la rodea y del cual el historiador es parte.
Метод розподілу людських ресурсів між військовими формуваннями
Authors: Думенко Микола 
Published: October 2023

Успішне вирішення завдань щодо відбиття збройної агресії в умовах ведення збройної боротьби сучасності можуть вирішити лише добре підготовлені та укомплектовані війська. Метою статті є розробка методу розподілу людських ресурсів між військовими формуваннями для підготовки кадровими органами оперативно-тактичного та оперативно-стратегічного рівнів обґрунтованих пропозицій командувачам (начальникам) до замислу операцій (бойових дій) для ухвалення рішення щодо маневру (перерозподілу) особового складу між Об’єднаними угрупуваннями військ. Під час проведення дослідження застосовано метод динамічного програмування, за допомогою якого вирішується оптимізаційна задача щодо знаходження такого оптимального розподілу людських ресурсів за m-періодів комплектування, за яких функція укомплектованості на останньому періоді комплектування буде максимальною. Оскільки укомплектованість залежить від значної кількості параметрів, які змінюються у часі, то для оптимального розподілу людських ресурсів необхідно проаналізувати та спрогнозувати зміни параметрів укомплектованості. Для цього застосовується метод прогнозування параметрів укомплектованості військових частин, який побудовано на методі нелінійної екстраполяції. Сутністю методу прогнозування укомплектованості військових частин Збройних сил України є використання логістично-ймовірнісної моделі опорного тренду комплектування, що змінюється за часом. Наукова новизна полягає в тому, що запропонований метод розроблений вперше, а практична значущість статті дозволяє вирішувати завдання, які постають перед Збройними силами України щоденно, проведення оптимального розподілу людських ресурсів між військовими формуваннями з урахуванням темпів мобілізаційного розгортання, обсягів надходження мобілізаційних людських ресурсів, безповоротних і санітарних втрат під час мобілізації та бойових дій.
PENERAPAN MODEL NAIVE BAYES UNTUK MEMPREDIKSI POTENSI PENDAFTARAN SISWA DI SMK TAMAN SISWA TELUK BETUNG BERBASIS WEB
Authors: Putri Sherlyn Eka Yuliana 
Published: October 2023

SMK Taman Siswa setiap awal tahun ajaran baru akan menyelenggarakan penerimaan calon peserta didik baru. Persaingan dalam menarik minat calon siswa baru untuk masuk SMK Taman Siswa dapat terjadi. Dengan adanya persaingan antar SMK, jumlah pendaftaran siswa baru setiap tahunnya akan mengalami peningkatan dan tidak menutup kemungkinan akan mengalami penurunan calon peserta didik baru, sehingga jumlah siswa baru di SMK tersebut tidak stabil. Permasalahannya adalah ketidakstabilan pendaftaran calon peserta didik baru di SMK Taman Siswa. Berdasarkan masalah tersebut, maka penulis merancang sebuah sistem Penerapan Model Naive Bayes Untuk Memprediksi Potensi Pendaftaran Siswa Di SMK Taman Siswa Teluk Betung Berbasis WEB. Sistem yang dapat melakukan prediksi potensi pendaftaran siswa baru yang akan masuk ke SMK Taman Siswa.Hasil akhir yang diperoleh adalah sebuah sistem informasi prediksi potensi pendaftaran siswa dengan menggunakan model naive bayes yang memiliki kemampuan untuk memprediksi potensi banyaknya siswa yang mendaftar dan tidak mendaftar di SMK Taman Siswa. Aplikasi ini diuji menggunakan perhitungan akurasi dimana hasilnya didapatkan tingkat akurasi sebesar 86% untuk prediksi potensi pendaftaran siswa.
ANALISA KERENTANAN WEBSITE FMIPA UNSRAT BERDASARKAN OPEN WEB APPLICATION SECURITY PROJECT TOP 10 FRAMEWORK
Authors: Soewoeh Christian Alderi Jeffta , Tenda Edwin , Ketaren Eliasta , Kalengkongan Wisard Widsli , Takaendengan Mahardika Inra 
Published: October 2023

Salah satu langkah preventif untuk meminimalisir dampak buruk serangan siber adalah dengan melakukan penilaian kerentanan yang hasilnya dapat dianalisa sesuai framework OWASP Top 10. Menurut hasil monitoring keamanan siber BSSN tahun 2021 menunjukkan bahwa serangan siber pada sektor pendidikan tinggi semakin meningkat. Oleh karena itu, penting bagi institusi pendidikan tinggi seperti FMIPA UNSRAT untuk meningkatkan keamanan siber mereka dan memperkuat perlindungan infrastruktur informasi vital mereka. Dengan mengikuti rekomendasi yang diberikan dalam penelitian ini, diharapakan dapat membantu FMIPA UNSRAT dalam meningkatkan perlindungan keamanan website dan mencegah serangan siber yang dapat membahayakan informasi penting mereka.
Flavonoids from <i>Impatiens grandulifera</i> and Their Antioxidant Activity
Authors: Whaley A. K. , Lukashov R. I. , Whaley A. O. , Zhokhova E. V. , Gurina N. S. , Goncharov M. U. , Yakovlev G. P. , Tsiarletskaya V. A. 
Published: October 2023

Introduction. The genus Impatiens L. includes about 850 species, which are found mainly in tropical and subtropical climate zones. The Indigenous people of Pakistan used pastes and extracts from I. glandulifera for the treatment of joint pain, anxiety and skin allergies [6]. Flowers of I. glandulifera are used in Bach flower remedies, which are used for sedation, relaxation and helping to balance emotional states.Aim. Isolation and structural elucidation of 11 phenolic constituents from the aerial parts of I. glandulifera and the evaluation of their antioxidant activity.Materials and methods. The aerial part of Impatiens glandulifera Royle was collected in the Leningrad region near the village of Orekhovo in 2021. Fractions were analyzed by analytical high performance liquid chromatography (HPLC) using a Prominence LC-20 (Shimadzu, Japan) equipped with a diode array detector. The isolation of individual compounds was carried out by column chromatography on open glass columns with sorbents of different selectivity, as well as by preparative HPLC using a Smartlina (Knauer, Germany) equipped with a spectrophotometric detector. The structure of isolated individual compounds was established by 1D and 2D NMR spectroscopy (Bruker Avance III 400 MHz, Germany). To study the antioxidant activity, we used solutions obtained by dissolving the isolated substances in a mixture of dimethyl sulfoxide and ethanol; an aqueous solution of vitamin C and an alcoholic solution of Trolox (Sigma-Aldrich, Japan).Result and discussion. Phytochemical analysis of the aerial parts of Impatiens glandulifera Royle. resulted in the isolation of 11 polyphenolic secondary metabolites (1-11) and their structures were elucidated. The antioxidant activity of all isolated compounds was evaluated.Conclusion. The maximum RAP values of eriodyctiol (3), kaempferol (1), and quercetin (2) did not differ significantly (p = 0.585) from those of the comparator preparations: vitamin C and Trolox, which indicates that the antioxidant effect of these three isolated compounds is comparable to the well-known antioxidants. However, the semi-effective concentrations of these substances are two or more times lower (p = 2.56 · 10–4) comparted with vitamin C.
Socialization of Making Organic Fertilizer to Increase Plant Productivity in the Banjarsari Village Community Ngajum Malang Regency
Authors: Laili Saimul 
Published: October 2023

The aim of this outreach is to educate the public that organic waste and animal waste have been very useful waste, for example as fertilizer but are rarely used due to lack of knowledge about it and the manufacturing process. Therefore, by providing socialization about making fertilizer from organic waste and animal waste, it can increase the added value of organic waste and animal waste and help the community increase plant productivity. Organic fertilizer is very good for plants because it can provide nutrients for plants. Its use can simultaneously loosen barren soil, increase porosity, aeration and the composition of microorganisms in the soil. Organic fertilizer is also useful for increasing the soil's water holding capacity so that it can store ground water longer. The process of making organic fertilizer can be done by decomposing or fermenting organic waste by planting it in a hole in the ground or a large pot and then filling it with soil, then the organic waste will naturally turn into organic fertilizer. Keyword: Organic Fertilizer, Garbage Animal Waste, Agricultural Pants
Seed treatment affected establishment and yield in two pennycress lines
Authors: Koirala Nasib , Barker David J. , Gesch Russ W. , Mohammed Yesuf Assen , Heller Nicholas J. , Hard Alexander W. , Wells Samantha S. , Phippen Winthrop B. , Tas Pamela , Lindsey Alexander J. 
Published: October 2023

IntroductionOilseed pennycress (Thlaspi arvense L.) is an emerging biofuel crop for use in the aviation industry that has potential as a rotational crop in corn (Zea mays L.)–soybean [Glycine max (L.) Merr.] cropping sequences. Ensuring autumn emergence of pennycress after early broadcast seeding is key because this practice may result in uneven spatial distribution due to the small seed size and variable germination, soil contact, and moisture availability. The objective of this research was to evaluate the impact of five seed treatments and enhancements on autumn establishment in two pennycress lines (MN106NS and tt8-t/ARV1) in broadcast seeding compared with no treatment.MethodsTested treatments were (i) gibberellic acid (GA) soak, (ii) fludioxonil fungicide, (iii) pelleting with diatomaceous earth and a commercial binder, (iv) fungicide plus pelleting, or (v) fungicide plus pelleting with GA added to the binder. Seeds were planted at nine sites in four U.S. states to assess establishment (stand counts and percentage canopy cover) in the autumn and spring and seed yield after maturity.ResultsThe MN106NS line had greater plants m−2 and percent green cover with treatments that included GA compared to the control. Line tt8-t/ARV1 had reduced stands when pelleted compared to the untreated, and establishment was unchanged when treated with GA compared to the untreated. Pelleting treatments without GA were not beneficial for stand establishment of either line. Seed yield for MN106NS was 20% greater than the untreated when treated with GA only or pelleted. Seed yield for tt8-t/ARV1 did not increase over the untreated with any treatment and was reduced by 20%–40% when pelleted.DiscussionThese results suggest minimal benefit of seed treatment and pelleting for the tested lines under broadcast seeding, though black-seeded lines may still benefit from GA treatment. Plant establishment and yield were negatively correlated with total precipitation post-planting, suggesting that excessive rainfall post-planting (&gt;60 mm) may impede establishment when broadcast seeded.
Secretome analysis of breast cancer cells to identify potential target proteins of Ipomoea turpethum extract-loaded nanoparticles in the tumor microenvironment
Authors: Swami Sanskriti , Mughees Mohd , Mangangcha Irengbam Rocky , Kauser Sana , Wajid Saima 
Published: October 2023

Background: Breast cancer is the leading cause of frequent malignancy and morbidity among women across the globe, with an increment of 0.5% incidences every year. The deleterious effects of traditional treatment on off-target surrounding cells make it difficult to win the battle against breast cancer. Hence, an advancement in the therapeutic approach is crucial. Nanotechnology is one of the emerging methods for precise, targeted, and efficient drug delivery in cells. The previous study has demonstrated the cytotoxic effect of Ipomoea turpethum extract on breast cancer cells delivered via NIPAAM-VP-AA nanoparticles (NVA-IT). Manipulating the tumor microenvironment (TME) to inhibit cancer progression, invasion, and metastasis seems to be very insightful for researchers these days. With the help of secretome analysis of breast cancer cells after treatment with NVA-IT, we have tried to find out the possible TME manipulation achieved to favor a better prognosis of the disease.Method: MCF-7 and MDA MB-231 cells were treated with the IC50 value of NVA-IT, and the medium was separated from the cells after 24 h of the treatment. Nano LCMS/MS analysis was performed to identify the secretory proteins in the media. Further bioinformatics tools like GENT2, GSCA, GeneCodis 4, and STRING were used to identify the key proteins and their interactions.Result: From the nano LCMS/MS analysis, 70 differentially expressed secretory proteins in MCF-7 and 191 in MDA MB-231 were identified in the cell’s media. Fifteen key target proteins were filtered using bioinformatics analysis, and the interaction of proteins involved in vesicular trafficking, cell cycle checkpoints, and oxidative stress-related proteins was prominent.Conclusion: This study concluded that I. turpethum extract-loaded NIPAAM-VP-AA nanoparticles alter the secretory proteins constituting the TME to cease cancer cell growth and metastasis.
PIH1D3-knockout rats exhibit full ciliopathy features and dysfunctional pre-assembly and loading of dynein arms in motile cilia
Authors: Zhang Tingting , Cui Shiquan , Xiong Xinrui , Liu Ying , Cao Qilin , Xia Xu-Gang , Zhou Hongxia 
Published: October 2023

Background: Recessive mutation of the X-linked gene, PIH1 domain-containing protein 3 (PIH1D3), causes familial ciliopathy. PIH1D3 deficiency is associated with the defects of dynein arms in cilia, but how PIH1D3 specifically affects the structure and function of dynein arms is not understood yet. To gain insights into the underlying mechanisms of the disease, it is crucial to create a reliable animal model. In humans, rats, and mice, one copy of the PIH1D3 gene is located on the X chromosome. Interestingly, mice have an additional, intronless copy of the Pih1d3 gene on chromosome 1. To develop an accurate disease model, it is best to manipulate the X-linked PIH1D3 gene, which contains essential regulatory sequences within the introns for precise gene expression. This study aimed to develop a tailored rat model for PIH1D3-associated ciliopathy with the ultimate goal of uncovering the intricate molecular mechanisms responsible for ciliary defects in the disease.Methods: Novel Pih1d3-knockout (KO) rats were created by using TALEN-mediated non-homologous DNA recombination within fertilized rat eggs and, subsequently, underwent a comprehensive characterization through a battery of behavioral and pathological assays. A series of biochemical and histological analyses were conducted to elucidate the identity of protein partners that interact with PIH1D3, thus shedding light on the intricate molecular mechanisms involved in this context.Results: PIH1D3-KO rats reproduced the cardinal features of ciliopathy including situs inversus, defects in spermatocyte survival and mucociliary clearance, and perinatal hydrocephalus. We revealed the novel function of PIH1D3 in cerebrospinal fluid circulation and elucidated the mechanism by which PIH1D3 deficiency caused communicating hydrocephalus. PIH1D3 interacted with the proteins required for the pre-assembly and uploading of outer (ODA) and inner dynein arms (IDA), regulating the integrity of dynein arm structure and function in cilia.Conclusion: PIH1D3-KO rats faithfully reproduced the cardinal features of ciliopathy associated with PIH1D3 deficiency. PIH1D3 interacted with the proteins responsible for the pre-assembly and uploading of dynein arms in cilia, and its deficiency led to dysfunctional cilia and, thus, to ciliopathy by affecting the pre-assembly and uploading of dynein arms. The resultant rat model is a valuable tool for the mechanistic study of PIH1D3-caused diseases.
Radiochemical and biological assessments of a PSMA-I&S cold kit for fast and inexpensive 99mTc-labeling for SPECT imaging and radioguided surgery in prostate cancer
Authors: Fuscaldi Leonardo Lima , Sobral Danielle Vieira , Durante Ana Claudia Ranucci , Mendonça Fernanda Ferreira , Miranda Ana Cláudia Camargo , Salgueiro Carla , de Castiglia Silvia Gomez , Yamaga Lilian Yuri Itaya , da Cunha Marcelo Livorsi , Malavolta Luciana , de Barboza Marycel Figols , Mejia Jorge 
Published: October 2023

The expression of prostate-specific membrane antigen (PSMA) is upregulated in prostate cancer (PCa) cells and PSMA-ligands have been radiolabeled and used as radiopharmaceuticals for targeted radionuclide therapy (TRT), single photon emission computed tomography (SPECT) or positron emission tomography (PET) molecular imaging, and radioguided surgery in PCa patients. Herein, we aimed at radiolabeling the PSMA-I&amp;S cold kit with 99mTc, resulting in a radiopharmaceutical with high radiochemical yield (RCY) and stability for SPECT imaging and radioguided surgery in PCa malignancies. Various pre-clinical assays were conducted to evaluate the [99mTc]Tc-PSMA-I&amp;S obtained by the cold kit. These assays included assessments of RCY, radiochemical stability in saline, lipophilicity, serum protein binding (SPB), affinity for LNCaP-PCa cells (binding and internalization studies), and ex vivo biodistribution profile in naive and LNCaP-PCa-bearing mice. The radiopharmaceutical was obtained with good RCY (92.05% ± 2.20%) and remained stable for 6 h. The lipophilicity was determined to be −2.41 ± 0.06, while the SPB was ∼97%. The binding percentages to LNCaP cells were 9.41% ± 0.57% (1 h) and 10.45% ± 0.45% (4 h), with 63.12 ± 0.93 (1 h) and 65.72% ± 1.28% (4 h) of the bound material being internalized. Blocking assays, employing an excess of unlabeled PSMA-I&amp;S, resulted in a reduction in the binding percentage by 2.6 times. The ex vivo biodistribution profile confirmed high accumulation of [99mTc]Tc-PSMA-I&amp;S in the tumor and the tumor-to-contralateral muscle ratio was ∼6.5. In conclusion, [99mTc]Tc-PSMA-I&amp;S was successfully obtained by radiolabeling the cold kit using freshly eluted [99mTc]NaTcO4, exhibiting good RCY and radiochemical stability. The preclinical assays demonstrated that the radiopharmaceutical shows favorable characteristics for SPECT imaging and radioguided surgery in PCa patients.
Carbon dots with light-responsive oxidase-like activity for colorimetric detection of dopamine and the catalytic mechanism
Authors: Jia Zhenzhen , Liu Yuna , Cheng Liangliang , Deng Zhichao , Zhang Mingzhen , Tuo Hang 
Published: October 2023

Introduction: Dopamine is one of the most significant neurotransmitters and plays an important role in the management of cognitive functions such as learning, memory, and behavior. The disorder of dopamine is associated with many major mental diseases. It is necessary to develop selective methods for the detection of dopamine.Methods: In this work, carbon dots (CDs) were synthesized by a solvothermal route using glutathione, L-histidine, and formamide as sources.Results: Under light irradiation, The CDs convert dissolved oxygen to singlet oxygen (1O2), which could oxidize TMB. When reduced dopamine was present, it suppressed the catalysis of CDs, then the absorption of the CDs-coupled TMB complex at 652 nm was diminished. Furthermore, it was revealed that the surface groups including hydroxyl, amino, carbonyl, and carboxyl groups of CDs were related to their light-responsive catalytic activity by surface modification. In the range of 0.5-15 μM, the CDs could afford a LOD of 0.25 μM for dopamine detection with fine linearity, also showing good selectivity.Discussion: The results from fetal bovine serum indicated the good applicability of the CDs in the determination of dopamine.
A combination of restudy and retrieval practice maximizes retention of briefly encountered facts
Authors: Ashby Stefania R. , Zeithamova Dagmar 
Published: October 2023

IntroductionIs retrieval practice always superior to restudy? In a classic study by Roediger and Karpicke, long-term retention of information contained in prose passages was found to be best when opportunities to restudy were replaced with opportunities to self-test. We were interested whether this striking benefit for repeated testing at the expense of any restudy replicates when study opportunities are brief, akin to a single mention of a fact in an academic lecture. We were also interested in whether restudying after a test would provide any additional benefits compared to restudying before test.MethodIn the current study, participants encountered academically relevant facts a total of three times; each time either studied (S) or self-tested (T). During study, participants predicted how likely they were to remember each fact in the future. During self-test, participants performed covert cued recall and self-reported their recall success. Final test followed immediately or after a delay (Experiment 1: 2 days, Experiment 2: 7 days).ResultsContrary to prior work, long-term memory was superior for facts the were restudied in addition to self-tested (SST &gt; STT = SSS). We further investigated whether restudy after a test (STS) provides additional benefits compared to restudy before test (SST). Restudying after a retrieval attempt provided an additional benefit compared to restudying before a retrieval attempt on an immediate test, but this benefit did not carry over a delay. Finally, exploratory analyses indicated that restudy after test improved the accuracy of participants' subjective predictions of encoding success.DiscussionTogether, our results qualify prior work on the benefits of repeated testing, indicating that balancing testing with repetition may allow for more information to be learned and retained. These findings offer new insights into the conditions that promote encoding and long-term retention, provide new constraints for existing cognitive theories of testing effects, and have practical implications for education.