bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the reservoir inflow prediction using TIGGE ensemble data and hydrological model for Dharoi Dam, India
Authors: Patel Anant , Yadav S. M. 
Published: October 2023

Abstract

Flooding occurs frequently compared to other natural disasters. Less developed countries are severely affected by floods. This research provides an integrated hydrometeorological system that forecasts hourly reservoir inflows using a full physically based rainfall–runoff and numerical weather models. This study develops a 5-day lead time reservoir inflow prediction using TIGGE ensemble datasets from ECMWF, UKMO, and NCEP for the Dharoi Dam in Gujarat, India. The ensemble data were post-processed using censored non-homogeneous Linear Regression and Bayesian model averaging approach. These post-processed data were used in a hydrological model to simulate hydrological processes and predict Dharoi Dam reservoir inflows. Results show that ECMWF with a BMA approach and HEC-HMS hydrological model can predict reservoir inflows in the Sabarmati River basin. The correlation result of an observed reservoir inflow is 0.91. This research can help regional water resource managers and government officials to plan and manage water resources.
Construction and Validation of a Prognostic Model Based on
Pyroptosis-related Genes in Bladder Cancer
Authors: Shen Chong , Han Chenyang , Li Zhi , Yan Yan , Li Chenyun , Chen Houyuan , Fan Zhenqian , Hu Hailong 
Published: October 2023

Background:
Bladder cancer (BCa) is a highly prevalent disease with a poor prognosis. There is no better forecasting method for it yet. Current studies demonstrate that pyroptosis
is involved in the development and progression of various cancers.

Methods:
This study employed bioinformatics techniques to analyze the data of BCa patients obtained from the TCGA and GEO databases in order to construct a prognostic risk model. The
TCGA dataset was used for the training set, and the multiple external datasets (including
GSE13507, GSE31684, GSE48075, IMvigor210, and GSE32894) were applied as the validation
sets. Prognostic-associated pyroptosis genes screened by univariate Cox regression analysis were
utilized to construct the lasso Cox regression model. GO and KEGG analysis results identified
the selected genes that are primarily involved in the inflammation and cell death processes. The
related patients were grouped into low- and high-risk groups. Kaplan–Meier survival analysis
was performed to compare survival differences between the risk groups. The accuracy of this
risk prediction model was assessed by ROC. We also applied the Human Protein Atlas (HPA) to
detect the protein expression of these genes. Subsequently, qRT-PCR was performed to verify
the expression of these model genes.

Results:
There are 29 pyroptosis-related genes with significant expression differences between
BCa and corresponding adjacent tissues, and 11 genes (SH2D2A, CHMP4C, MRFAP1L1,
GBP2, EHBP1, RAD9A, ANXA1, TMEM109, HEYL, APOL2, ORMDL1) were picked by univariate and LASSO Cox regression analysis. Immunological cell infiltration and ssGSEA results
further indicated that the low and high-risk groups were substantially correlated with the immune
status of BCa patients. According to TCGA and multiple external datasets, Kaplan-Meier survival curves showed the overall survival rate of the high-risk group to be decreased. ROC curves
showed the model established to be accurate and reliable. Moreover, the HPA database also
demonstrated the verification of the modeled genes’ expression in BCa and normal bladder tissue using the HPA database. qRT-PCR results also suggested the up-regulated EHBP1 and
down-regulated RAD9A mRNA expression levels to be confirmed in 15 pairs of BCa and corresponding adjacent tissues.

Conclusion:
This study presents the development and validation of a novel gene signature associated with pyroptosis, which holds the potential for predicting patient outcomes in BCa and
providing insights into the immune microenvironment of BCa.
Poziom wyszczepialności i postawy rodziców noworodków i niemowląt, a lęk w okresie pandemii
Authors: Kochman Dorota , Szklarczyk Kasandra 
Published: October 2023

Wstęp. Szczepienia są najskuteczniejszą formą profilaktyki chorób zakaźnych. Na efektywność szczepień wpływa przede wszystkim ilość osób zaszczepionych. Stały wzrost liczby osób niepoddających swoich dzieci szczepieniom ochronnym powoduje obniżenie odporności zbiorowej. Istotne jest edukowanie społeczeństwa w zakresie konieczności realizacji kalendarza szczepień.
Cel. Celem pracy była analiza poziomu wyszczepialności i postaw rodziców noworodków i niemowląt oraz poziom odczuwanego stresu w okresie pandemii w badanej grupie.
Materiał i metody. W badaniach własnych wykorzystano analizę dokumentacji medycznej, metodę sondażu diagnostycznego z użyciem ankiety własnego autorstwa, metodę szacowania przy pomocy kwestionariusza mini – COPE. W badaniu wzięło udział 100 osób. W obliczeniach przyjęto stopień statystyczności p < 0,05.
Wyniki. Z badań własnych wynika, że 99% ankietowanych poddało swoje dzieci szczepieniom ochronnym. Na decyzję o poddaniu dziecka szczepieniom wpłynęły przede wszystkim strach przed zachorowaniem dziecka oraz łagodniejsze przebycie choroby po zaszczepieniu, natomiast informacje na temat szczepień ankietowani czerpali głównie od personelu medycznego. Większość badanych uważa, że zasadnym jest, iż program szczepień ochronnych jest obowiązkowy. Część ankietowanych obawia się wystąpienia niepożądanych odczynów poszczepiennych. Większość badanych uważa, że pandemia koronawirusa nie wpłynęła na ich decyzję w zakresie konieczności realizacji szczepień ochronnych. Wykształcenie, pozostawało w istotnej statystycznie, średniej korelacji z wynikami zagadnienia czy koronawirus SARS-CoV-2 sprawił, że zmieniło się podejście do szczepień oraz w korelacji niskiej z wynikami zagadnienia zdanie na temat konieczności stawienia się z dzieckiem na szczepienia ochronne w czasie pandemii wirusa SARS-CoV-2 (p<0,05). Wyrażając opinię na temat konieczności stawienia się z dzieckiem na szczepienia ochronne w czasie pandemii wirusa SARS-CoV-2, najwięcej kobiet z wykształceniem podstawowym / gimnazjalnym wskazało, że boi się o kontakt z wirusem SARS-CoV-2 podczas wizyty w celu realizacji szczepień ochronnych. Zjawisko pandemii istotnie wpłynęło na poziom odczuwanego stresu w badanej grupie rodziców – odnotowano wyższą średnią odczuwanego lęku podczas trwania pandemii niż przed jej wystąpieniem.
Wnioski. Badani mają w większości pozytywny stosunek do konieczności realizacji szczepień ochronnych, a pandemia nie miała istotnego wpływu na konieczność ich realizacji. Badani zarówno w okresie przed pandemią oraz w trakcie jej trwania wciąż uważają szczepienia za zasadne. Zjawisko pandemii wpłynęło na poziom odczuwanego stresu. Zdecydowanie wyższą średnią odczuwanego lęku odnotowano w czasie trwania pandemii – 5,82 punktu, przy średniej – 3,04 punktu w okresie przed pandemią.
THE ROLE OF ANEMIA IN THE DEVELOPMENT OF NON-FATAL CARDIOVASCULAR EVENTS AND PREDICTION OF THEIR RISK IN PATIENTS WITH CORONARY HEART DISEASE
Authors: Zaiats I.O. , Khanyukov O.O. 
Published: October 2023

РОЛЬ АНЕМІЇ В РОЗВИТКУ НЕФАТАЛЬНИХ СЕРЦЕВО-СУДИННИХ ПОДІЙ ТА ПРОГНОЗУВАННЯ РИЗИКУ ЇХ ВИНИКНЕННЯ У ПАЦІЄНТІВ З ІШЕМІЧНОЮ ХВОРОБОЮ СЕРЦЯ
O.O. Ханюков1, I.O. Заяць2
1Дніпровський державний медичний університет,
кафедра внутрішньої медицини 3,
м. Дніпро, Україна,
ORCID: 0000-0003-4146-0110,
е-mail: khanyukov.al@gmail.com;
2Європейський медичний університет,
кафедра внутрішньої медицини,
м. Дніпро, Україна,
ORCID: 0000-0001-8225-5901,
е-mail: irinazayats8gb@gmail.com
Резюме. Мета дослідження: вивчити вплив залізодефіцитної анемії (ЗДА) на ризик розвитку нефатальних серцево-судинних подій (ГІМ, прогресії стенокардії напруги та хронічної серцевої недостатності, виникнення тахіаритмій) у пацієнтів з ІХС; розробити математичні моделі оцінки ризику розвитку нефатальних ускладнень (ГІМ і прогресії хронічної серцевої недостатності) у хворих на ІХС, в залежності від рівню гемоглобіну.
Методи. В дослідженні брали участь 95 хворих на ІХС, які перебували на стаціонарному лікуванні в терапевтичних та кардіологічних відділеннях ЛПУ міста Дніпро. Основну групу склали 53 хворих з супутньою анемією, контрольну – 42 пацієнти без анемії. З метою виявлення нефатальних ускладнень ІХС (ГІМ, декомпенсації СН, аритмії) і з’ясування причин їх виникнення, у пацієнтів обох груп ретроспективно проведено 8-річний аналіз медичної документації, з наступним кореляційним аналізом та визначенням факторів, які сприяють розвитку нефатальних серцево-судинних подій, і розробкою математичної моделі ризику ймовірних ускладнень впродовж 5-8 років.
Результати. Отримані статистично значущі показники несприятливого впливу анемії на виникнення кардіо-васкулярних подій (прогресії ішемії міокарду, серцевої недостатності, тахіаритмій) (р<0,05); методом кореляційного аналізу визначені предиктори виникнення ГІМ (стаж ГХ, рівні гемоглобіну і загального холестерину у сироватці крові, а також ЧСС і PsАТ) і прогресування ХСН (вік, стаж ФП, наявність ХНН 3 ст., клінічна стадія СН, рівень гемоглобіну, ЧСС) у пацієнтів на ІХС; розроблені математичні моделі ризику розвитку ГІМ та декомпенсації СН.
Висновки. Анемія сприяє росту госпіталізацій з приводу прогресії ішемії міокарду, СН і розвитку тахіаритмій (р<0,05). Розроблені моделі ймовірності розвитку ГІМ і прогресії СН продемонстрували відмінні результати. Ймовірність настання ГІМ виникає при значенні Р > 0,47% (Se = 87,9%, Sp = 96,8%, De = 93,7%), а вірогідність прогресії ХСН – при Р > 0,43 (Se = 87,8%, Sp = 87,0%, De = 87,4%).
Ключові слова: ішемічна хвороба серця, серцево-судинні ускладнення, хронічна серцева недостатність, анемія, прогнозування.
Relationship of burnout to nurse job satisfaction at Semen Gresik Hospital
Authors: Al Fanani Tamam , Paskarini Indriati 
Published: October 2023

Introduction: The nursing profession is a professional and technical profession that is distinguished by the combination of mental and physical labor and the high risk of work. A nurse can feel work exhaustion or usually called burnout and affects job satisfaction Objectives: The purpose of this study was to analyze the relationship between burnout and job satisfaction among nurses. Methods: The research design used was descriptive statistical and correlational analysis with a cross-sectional approach. A total sample of 115 nurses who met the inclusion criteria was selected using the simple random sampling technique. Data were analyzed using Spearman's rank with α = 0.05. Results: The results showed that the majority of participants were at a moderate level of burnout (n = 93, 89%). The study also found that the majority of participants have an ambivalence level toward job satisfaction (n = 54, 47.0%), and burnout has a negative correlation with job satisfaction (p = 0.000 with a correlation value of -0.483). Conclusions: The level of burnout was correlated with job satisfaction. therefore it is necessary to reduce burnout levels so that nurse job satisfaction increases and can improve nurse performance.
Effect of face-to-face psychoeducation intervention combined with motivational interviewing on adherence in prevention and treatment of pulmonary tuberculosis patients
Authors: Choliq Idham , Nasrullah Dede , Sukadiono  , Fitriyani Vika Ramadhana 
Published: October 2023

Introduction: TB can be cured if patients routinely seek treatment for six months without breaking. Poor adherence to tuberculosis treatment is a global health challenge. Whereas adherence to the treatment regimen is important for tuberculosis (TB) control. The consequences of this non-compliance lead to treatment failure and the risk of infection of the disease is widespread. Objectives: The objective of the study is to examine what Face-to-Face Psychoeducation Intervention Combined with Motivational Interviewing effective to improve Adherence in Prevention and Treatment of Pulmonary Tuberculosis Patients. Methods: The research design used quantitative with experimental quasi research design t. The research was conducted at 4 Community Health Centers (Puskesmas), namely Puskesmas Takal, Puskesmas Perak, Puskesmas Pegirian and Puskesmas Sutopo in Surabaya. Through purposive sampling, the sample number was 60 respondents, divided by 30 respondents for the intervention group and 30 respondents for the control group. Results: There was a significant difference after the intervention. In the intervention group, there were changes in outcomes in both preventive adherence (12.37) and medication adherence (4.52). While in the control group, only the value of prevention compliance experienced a change of 5.67. Conclusions: Face-to-face method combined with motivation interviewing is effective in improving prevention and treatment adherence in TB patients. Motivational interviewing has a tendency to reduce hopelessness, an increasing motivation to recover and the admonition of taking medication in tuberculosis patients.
Comparison of vanilla extract intervention group and control group on neonatal pain and comfort levels during venous blood sampling
Authors: Ilmiasih Reni 
Published: October 2023

Introduction: Taking venous blood in neonates is always uncomfortable and painful. Pain in taking venous blood is bad for neonates. Short-term effects that occur include increased pulse, and tissue damage around the venous blood collection area. Long-term impacts can be disrupted psychological aspects and the development of neonatal behavior. Untreated discomfort and pain can lead to complications, including hyperalgesia and changes in the experience of pain. Objectives: The purpose of this study was to analyze the effect of giving vanilla extract to the pain level and comfort level of neonates who had venous blood taken. Methods: The type of research is Quasy Experiment with Control Group post test only design. The sampling technique was purposive sampling for 3 months of data collection with a total of 40 respondents. Data analysis using the Independent T Test. Results: The results showed that there was no significant difference in the pain scales of the two groups (p=0.51), but the average pain scale was higher in the control group. There is a significant difference in the results of the front comfort score p value = 0.00. These results are in accordance with previous research that the vanilla concentration of 0.64% and 2% could not significantly reduce pain. It is possible that the results will be different in further studies with a larger number of respondents and different techniques and doses. The results showed that there was no significant difference in the pain scales of the two groups (p=0.51), but the average pain scale was higher in the control group. There is a significant difference in the results of the front comfort score p value = 0.00. These results are in accordance with previous research that the vanilla concentration of 0.64% and 2% could not significantly reduce pain. It is possible that the results will be different in further studies with a larger number of respondents and different techniques and doses. The results showed that there was no significant difference in the pain scales of the two groups (p=0.51), but the average pain scale was higher in the control group. There is a significant difference in the results of the front comfort score p value = 0.00. Conclusions: These results are in accordance with previous research that the vanilla concentration of 0.64% and 2% could not significantly reduce pain. It is possible that the results will be different in further studies with a larger number of respondents and different techniques and doses.
Unlocking the Potential of High-Resolution Satellite Imagery for Soybean Phenotyping and Maturity Estimation in Plant Breeding
Authors: Mazis Anastasios , Barbeau Adam , Linares Julien , Das Pringale Kumar , Barr Jeremiah , Coles Nathan 
Published: October 2023

Plant breeding programs demand efficient and accurate methods for crop
phenotyping, especially for economically important crops like soybeans.
Traditional manual assessment methods are labor-intensive and prone to
errors. The emerging field of phenomics leverages advanced technologies,
including high-resolution satellite and drone imagery, to monitor crops
in a time, cost and labor efficient way. Drones offer localized,
high-resolution data but have limitations in coverage and operator
skills. In contrast, high-resolution satellite imagery provides
broad-scale views of the vegetation with increasing improvements in
spatial and temporal resolution.
Our study investigates the potential of high-resolution satellite
imagery as an alternative to drone imagery for assessing soybean
maturity and monitoring the crop condition in a small plot breeding
program. We compare the efficiency of these two technologies and we
explore the utilization of various vegetation indices (VIs) derived from
satellite-based multispectral imaging sensors for maturity estimation,
indirect assessment of essential plant traits and identification of the
growing patterns of different maturity groups.
Our findings reveal the promise of high-resolution satellite imagery as
a valuable tool in soybean phenotyping, addressing the spatial scale
challenges in breeding programs. With advances in spatial resolution,
satellites can provide detailed insights into crop health, productivity,
and resource management. This research contributes to the evolution of
precision agriculture, offering a cost-effective and scalable solution
for monitoring soybean maturity and enhancing crop adaptability and
yield.
Comparative characteristics of pneumonia caused by <i>Mycoplasma pneumoniae</i> in children
Authors: Bevza S. L. , Molochkova O. V. , Kovalev O. B. , Shamsheva O. V. , Sakharova A. A. , Korsunsky A. A. , Parshina M. V. , Burkova K. G. , Labuzova E. A. , Sokolova N. V. 
Published: October 2023

The urgency of the problem of community-acquired pneumonia in children is due to the high incidence rate. In the etiological structure of bacterial pneumonia, Streptococcus pneumoniae and Mycoplasma pneumonia (Mp) prevail.Purpose: to identify clinical, laboratory and instrumental features of mycoplasmal pneumonia in children.Materials and methods. A retrospective, single-center cohort study of 266 case histories of children aged 4 months to 17 years who were in Children’s City Clinical Hospital No. 9 in 2019 with a referral diagnosis of pneumonia was carried out. To verify the diagnosis of pneumonia, the method of chest X-ray was used, for the etiological diagnosis, the method of PCR swabs from the nasopharynx, ELISA for the detection of antibodies of the IgM and IgG classes was used. Results. The diagnosis of pneumonia was confirmed in 190 children. The diagnosis of pneumonia caused by M. pneumoniae (MpP) was established in 76 (40%) children, they made up the 1st group. The remaining 114 (60%) children with community-acquired pneumonia of another etiology (CAP) made up the 2nd group – comparisons. The diagnosis of MpP was confirmed in 46 (60.5%) children by the detection of IgM, in 12 (15.8%) by the detection of Mp genetic material, and in 18 (23.7%) by positive both IgM and PCR. The median age of children in the group with MpP was 9.6 years, in the comparison group – 4 years (p<0.01). Significantly more often MpP occurs in children aged 11–17 years (p < 0.01), and CAP – up to 7 years (p < 0.01). With MpP, catarrhal phenomena in the form of hyperemia of the oropharynx, nasal congestion, and unproductive cough are observed less frequently than with CAP. With MpP, rales in the lungs are heard more often than with CAP, they are significantly more often wet (p<0.01). Respiratory failure and dyspnea are less common in MpP than in CAP. Bilateral lesions and lesions of the upper lobe of the lungs are more often detected in MpP, and in CAP – right-sided lesions. In the general blood test, leukocytosis, incl. above 15 thousand/µl, as well as leukopenia below 4 thousand/µl were significantly more frequent in the group of patients with CAP (p<0.01). Conclusion. No clear clinical and laboratory criteria for mycoplasmal etiology of pneumonia have been obtained, which dictates the need for laboratory confirmation for the choice of therapy tactics.
Generalized Varicella Zoster infection in a patient with lymphogranulomatosis after bone marrow transplantation: clinical and laboratory characteristics and virus genotyping
Authors: Matsiyeuskaya N. V. , Samoilovich E. O. , Semeyko G. V. , Gvozdelyuk O. V. , Yushkevich A. S. 
Published: October 2023

A description of a laboratory confirmed clinical case of generalized Varicella Zoster infection in a patient with lymphogranulomatosis after bone marrow transplantation is presented.Detection of the Varicella Zoster virus in biological material was carried out by real-time PCR using the RealBest DNA VZV test system manufactured by Vector-BEST, Russian Federation. Isolation of viral DNA from biological material was performed using the ArtRNA MiniSpin kit (ArtBioTech, Belarus) or QIAamp DNA mini kit (QIAGEN, Germany).The disease had an atypically severe course with a multiorgan lesion, represented not only by lesions of the skin and mucous membranes, but also by the development of encephalitis, myocarditis, and pneumonia. The disease was characterized by an acute onset, with a pronounced intoxication syndrome, signs of pancreatitis with the appearance of a widespread vesicular rash on the trunk and extremities, prone to fusion, located, including on the scalp, on the feet and palms. The disease was complicated by a secondary bacterial infection, in connection with which the patient received both antiviral treatment and broad-spectrum antibiotic therapy.The virus was assigned to clade 3 (or E2 genotype according to the old classification), the same genotype as the viruses circulating in Minsk. This case is the first described case of generalized VZV infection in the Republic of Belarus, confirmed by laboratory using molecular genetic methods.