bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive biomarkers of response and survival following immunotherapy with a PD-L1 inhibitor benmelstobart (TQB2450) and antiangiogenic therapy with a VEGFR inhibitor anlotinib for pretreated advanced triple negative breast cancer
Authors: Han Yiqun , Wang Jiayu , Sun Tao , Ouyang Quchang , Li Jianwen , Yuan Jie , Xu Binghe 
Published: November 2023

AbstractIn our phase Ib trial (ClinialTrials.gov Identifier: NCT03855358), benmelstobart (TQB2450), a novel humanized IgG1 antibody against PD-L1, plus antiangiogenic multikinase inhibitor, anlotinib, demonstrated promising antitumor activities in pretreated triple negative breast cancer (TNBC) patients. We conducted explorative analyses of genomic biomarkers to explore the associations with treatment response and survival outcomes. Targeted next generation sequencing (NGS) was undertaken toward circulating tumor DNA (ctDNA) collected from peripheral blood samples prior to the start of treatment and after disease progression. A total of 31 patients received targeted NGS and functional driver mutations in 29 patients were analyzed. The most frequent mutations were TP53 (72%), MLL3 (28%), and PIK3CA (17%). At a blood-based tumor mutational burden (bTMB) cutoff of 6.7 mutations per megabase, patients with low bTMB showed better response to anlotinib plus TQB2450 (50% vs. 7%, P = 0.015) and gained greater PFS benefits (7.3 vs. 4.1 months, P = 0.012) than those with high bTMB. At a maximum somatic allele frequency (MSAF) cutoff of 10%, a low MSAF indicated a better objective response (43% vs. 20%) as well as a significantly longer median PFS (7.9 vs. 2.7 months, P < 0.001). Patients with both low MSAF and low bTMB showed a notably better objective response to anlotinib plus TQB2450 (70% vs. 11%, P < 0.001) and a significantly longer median PFS (11.0 vs. 2.9 months, P < 0.001) than patients with other scenarios. Our findings support future studes and validation of MSAF and the combined bTMB-MSAF classification as predictive biomarkers of immune checkpoint inhibitor-based regimens in advanced TNBC patients.
City-level population projection for China under different pathways from 2010 to 2100
Authors: Zhang Shangchen , Zhao Mengzhen , Liu Zhao , Yang Fan , Lu Bo , Zhao Zhenping , Gu Kuiying , Zhang Shihui , Lei Mingyu , Zhang Chi , Wang Can , Cai Wenjia 
Published: November 2023

AbstractCities play a fundamental role in policy decision-making processes, necessitating the availability of city-level population projections to better understand future population dynamics and facilitate research across various domains, including urban planning, shrinking cities, GHG emission projections, GDP projections, disaster risk mitigation, and public health risk assessment. However, the current absence of city-level population projections for China is a significant gap in knowledge. Moreover, aggregating grid-level projections to the city level introduces substantial errors of approximately 30%, leading to discrepancies with actual population trends. The unique circumstances of China, characterized by comprehensive poverty reduction, compulsory education policies, and carbon neutrality goals, render scenarios like SSP4(Shared Socioeconomic Pathways) and SSP5 less applicable. To address the aforementioned limitations, this study made three key enhancements, which significantly refines and augments our previous investigation. Firstly, we refined the model, incorporating granular demographic data at the city level. Secondly, we redesigned the migration module to consider both regional and city-level population attractiveness. Lastly, we explored diverse fertility and migration scenarios.
The volatilome signatures of Plasmodium falciparum parasites during the intraerythrocytic development cycle in vitro under exposure to artemisinin drug
Authors: Stead Zenaida , Capuano Rosamaria , Di Natale Corrado , Pain Arnab 
Published: November 2023

AbstractVolatile organic compounds (VOCs) comprise a diverse range of metabolites with high vapour pressure and low boiling points. Although they have received attention, they are a largely unexplored part of the metabolome. Previous studies have shown that malaria infections produce characteristic, definitive, and detectable volatile signatures. Many transcriptional and metabolic differences are observed at different stages of the parasite Intraerythrocytic Developmental Cycle (IDC) as well as when artemisinin-resistant parasites are put under drug pressure. This prompted our research to characterize whether these responses are reflected at a volatile level in malaria during the IDC stages using gas chromatography-mass spectrometry. We investigated whether the resistant P. falciparum parasites would produce their own characteristic volatilome profile compared to near-isogenic wild-type parasite in vitro; firstly at three different stages of the IDC and secondly in the presence or absence of artemisinin drug treatment. Finally, we explored the VOC profiles from two media environments (Human serum and Albumax) of recently lab-adapted field parasite isolates, from Southeast Asia and West/East Africa, compared to long-term lab-adapted parasites. Recognizable differences were observed between IDC stages, with schizonts having the largest difference between wild type and resistant parasites, and with cyclohexanol and 2,5,5-trimethylheptane only present for resistant schizonts. Artemisinin treatment had little effect on the resistant parasite VOC profile, whilst for the wild type parasites compounds ethylbenzene and nonanal were greatly affected. Lastly, differing culturing conditions had an observable impact on parasite VOC profile and clustering patterns of parasites were specific to geographic origin. The results presented here provide the foundation for future studies on VOC based characterization of P. falciparum strains differing in abilities to tolerate artemisinin.
Exploring risk factors of drive for muscularity and muscle dysmorphia in male adolescents from a resource-limited setting in Burkina Faso
Authors: Terhoeven Valentin , Nikendei Christoph , Bountogo Mamadou , Friederich Hans-Christoph , Ouermi Lucienne , Sié Ali , Harling Guy , Bärnighausen Till 
Published: November 2023

AbstractIn low-income countries, Muscle Dysmorphia (MD) has only been investigated in adult south African amateur-bodybuilders. To date, there is no epidemic study about MD or its cardinal symptom “drive for muscularity” (DFM) and its impact on young men’s lives in African low-income settings. We analyzed a population-representative cross-sectional study of 838 adolescent males aged 12–20 in the rural northwestern Burkina Faso. Participants were assessed for MD with the research criteria of Pope and its cardinal symptom DFM based on the DFM scale (DMS). Since DFM has not been studied in a comparable sample so far, all possible influencing variables were examined exploratively in a linear regression model. Many respondents were underweight (41.5%) and few overweight (1.3%). No-one met standard clinical MD criteria. While 60.1% of 837 wished to be more muscular, only 8.7% of 824 desired a lower body-fat percentage. Regression analysis revealed that higher DMS scores were associated with greater internalization of the muscular body ideal, going to school, living in a rural area, older age, and a history of having faced sexual harassment or assault, but not with media exposure. Our results show that levels of DMS in Burkinabe adolescents were elevated. Risk factors for DFM in environmental circumstances where undernutrition and poverty are common are discussed.
Research on permanent magnet synchronous motor algorithm based on linear nonlinear switching self-disturbance rejection control
Authors: Liu Xiangde , Li Yu , Xia Liang , Tan Xianfeng , Cao Xiang 
Published: November 2023

AbstractThis paper presents a linear-nonlinear switching control strategy, called Switching Active Disturbance Rejection Control (SADRC), to enhance the disturbance rejection capability of the speed controller in a servo system. SADRC combines the advantages of Linear Active Disturbance Rejection Control (LADRC) and Nonlinear Active Disturbance Rejection Control (NLADRC), and introduces a parameter to switch between nonlinear and linear control, thereby improving the robustness of the servo system. Firstly, the mathematical model of the motor is analyzed as the starting point of the paper. Then, the basic principles of Active Disturbance Rejection Control (ADRC) are analyzed, and improvements are made to address its limitations, resulting in the design of SADRC. The parameters introduced in SADRC are analyzed to determine their appropriate ranges. Finally, the performance of SADRC is validated by comparing the rotational effects of Permanent Magnet Synchronous Motor (PMSM).
Inferring individual evaluation criteria for reaching trajectories with obstacle avoidance from EEG signals
Authors: Iwane Fumiaki , Billard Aude , Millán José del R. 
Published: November 2023

AbstractDuring reaching actions, the human central nerve system (CNS) generates the trajectories that optimize effort and time. When there is an obstacle in the path, we make sure that our arm passes the obstacle with a sufficient margin. This comfort margin varies between individuals. When passing a fragile object, risk-averse individuals may adopt a larger margin by following the longer path than risk-prone people do. However, it is not known whether this variation is associated with a personalized cost function used for the individual optimal control policies and how it is represented in our brain activity. This study investigates whether such individual variations in evaluation criteria during reaching results from differentiated weighting given to energy minimization versus comfort, and monitors brain error-related potentials (ErrPs) evoked when subjects observe a robot moving dangerously close to a fragile object. Seventeen healthy participants monitored a robot performing safe, daring and unsafe trajectories around a wine glass. Each participant displayed distinct evaluation criteria on the energy efficiency and comfort of robot trajectories. The ErrP-BCI outputs successfully inferred such individual variation. This study suggests that ErrPs could be used in conjunction with an optimal control approach to identify the personalized cost used by CNS. It further opens new avenues for the use of brain-evoked potential to train assistive robotic devices through the use of neuroprosthetic interfaces.
Non-invasive assessment of skin hydration and sensation with diffuse reflectance spectroscopy
Authors: Chen Ying-Yu , Tzeng Shih-Yu , Yen Yun-Yo , Cheng Nan-Yu , Tseng Sheng-Hao 
Published: November 2023

AbstractThe skin is a vital organ in the human body, providing essential functions such as protection, sensation, and metabolism. Skin hydration is one of the crucial factors in maintaining normal skin function. Insufficient skin hydration can lead to dryness, shedding of the stratum corneum, a decrease in skin barrier function, and may cause skin inflammation. Therefore, maintaining or improving skin hydration is critical in promoting healthy skin. Currently, the commonly used method for measuring skin hydration is bioelectrical capacitance analysis, which is often affected by environmental humidity and can only provide limited information. To overcome these limitations, this study used diffuse reflectance spectroscopy (DRS) in the wavelength range of 400-1000 nm to quantify skin absorption and scattering modulation caused by changes in skin hydration states. The advantages of this technique include rapid measurements, non-invasiveness, a straightforward optical setup, and suitability for prolonged skin monitoring. We found that DRS-derived skin absorption coefficients had a correlation coefficient of 0.93 with the skin capacitance at various skin hydration states. In addition, our findings reveal that absorption and scattering coefficients may be useful in discerning skin hydration enhancement induced by applying soaked cotton pads or cosmeceutical facial masks, as well as evaluating skin sensation. This study verifies that the DRS method could be a convenient and effective tool for evaluating skin hydration related information.
Assessing different oil sources efficacy in reducing environmental heat-stress effects via improving performance, digestive enzymes, antioxidant status, and meat quality
Authors: Elbaz Ahmed M. , Zaki Engy F. , Salama Atif A. , Badri Faisal B. , Thabet Hany A. 
Published: November 2023

AbstractAdding oil to the feed of genetically improved broilers is necessary to provide energy requirements, in addition to enhancing metabolism, growth performance, immune response. This study aims to reveal the effect of adding different oil sources in the diets of broilers exposed to environmental heat stress on performance, digestibility, oxidative status, plasma lipids, fatty acids content, and meat quality. Six hundred twenty-five one-day-old broiler chicks were randomly distributed to five groups as follows: the first group fed a diet without oil (CON) as a control, while the second to the fifth group fed a diet containing soy oil (SO), corn oil (CO), olive oil (OO), and fish oil (FO), respectively. Results indicated a significant deterioration in growth performance, carcass traits, and oxidative state with a significant decrease in carcass quality in heat-stressed chickens fed the CON diet. Results showed increased growth, enhanced feed conversion ratio, and carcass dressing in broilers fed the oil-supplemented diet compared to the control diet, however, the digestive enzymes activity was not affected by receiving an oil-supplemented diet. The best performance was in chickens fed OO and SO, compared with FO and CO. Plasma aspartate aminotransferase (AST), and alanine aminotransferase (ALT) increased in broilers fed an oil-supplemented diet. Plasma high-density lipoprotein (HDL), and superoxide dismutase (SOD) remarkably increased in broilers fed OO, whereas the malondialdehyde (MDA) decreased compared to the other groups. Adding different dietary oil sources enhanced the breast muscle's fatty acid composition. Broiler diets supplemented with oils positively affected meat quality by enhancing color measurements, and TBA values, while the best were in chicken fed OO. It was concluded that adding dietary oil at 3% in the diets of broiler chicken exposed to environmental heat stress positively affected growth performance, enhanced oxidative status, and meat quality, best results were in broilers fed a diet that included olive oil.
Insights on hexavalent chromium(VI) remediation strategies in abiotic and biotic dual chamber microbial fuel cells: electrochemical, physical, and metagenomics characterizations
Authors: Khater Dena Z. , Amin R. S. , Fetohi Amani E. , Mahmoud Mohamed , El-Khatib K. M. 
Published: November 2023

AbstractHexavalent chromium [Cr(VI)] is one of the most carcinogenic and mutagenic toxins, and is commonly released into the environemt from different industries, including leather tanning, pulp and paper manufacturing, and metal finishing. This study aimed to investigate the performance of dual chamber microbial fuel cells (DMFCs) equipped with a biocathode as alternative promising remediation approaches for the biological reduction of hexavalent chromium [Cr(VI)] with instantaneous power generation. A succession batch under preliminary diverse concentrations of Cr(VI) (from 5 to 60 mg L−1) was conducted to investigate the reduction mechanism of DMFCs. Compared to abiotic-cathode DMFC, biotic-cathode DMFC exhibited a much higher power density, Cr(VI) reduction, and coulombic efficiency over a wide range of Cr(VI) concentrations (i.e., 5–60 mg L−1). Furthermore, the X-ray photoelectron spectroscopy (XPS) revealed that the chemical functional groups on the surface of biotic cathode DMFC were mainly trivalent chromium (Cr(III)). Additionally, high throughput sequencing showed that the predominant anodic bacterial phyla were Firmicutes, Proteobacteria, and Deinococcota with the dominance of Clostridiumsensu strict 1, Enterobacter, Pseudomonas, Clostridiumsensu strict 11 and Lysinibacillus in the cathodic microbial community. Collectively, our results showed that the Cr(VI) removal occurred through two different mechanisms: biosorption and bioelectrochemical reduction. These findings confirmed that the DMFC could be used as a bioremediation approach for the removal of Cr(VI) commonly found in different industrial wastewater, such as tannery effluents. with simultaneous bioenergy production.
Mitigation of PWR fuel assembly vibrations using bio-inspired nozzles
Authors: Gad-el-Hak Ibrahim , Mureithi Njuki , Karazis Kostas , Painter Brian 
Published: November 2023

AbstractJet flows injected in a transverse flow need rapid and effective mixing for various applications ranging from medicine injection into bloodstreams to nuclear pressurized water reactors (PWRs). Inspired by marine organisms, spiral snails, and sharks, bio-inspired nozzles are proposed and experimentally investigated to explore their advantages in suppressing nuclear fuel assembly vibrations. It has been observed that a combination of axial flow and jet cross-flow causes vibrations of fuel rods and potential wear at spacer grid supports. Marine biomimetics is used to improve the mixing between the jet flow and surrounding fluid flows. Inspired by the structure of gastropod shells, a variable whorl spacing nozzle is proposed to induce a swirling jet flow to enhance the mixing rate with the flow inside the reactor cores. In addition, the smooth maneuverability of the sharks highlights the importance to include gill slits structure into nozzles. This work focuses on mitigating PWR fuel assembly vibrations using two biomimetic nozzles, a snail nozzle and a shark nozzle. These two nozzles are proposed to improve the mixing rate between the injected flow and the primary coolant flow, resulting in a reduced jet flow effect on fuel rods. A single-span mock-up PWR array is designed, fabricated, and instrumented to mimic the real nuclear fuel assembly. The array is experimentally tested under combined axial flow and jet cross-flow to investigate its dynamical behavior. Three different nozzles, a basic circular nozzle, a snail nozzle, and a shark nozzle, are tested. The research investigates the ability of the proposed marine biomimetic nozzles to suppress the vibration of the rod bundle by comparing the results from the three tested nozzles. The obtained results suggest that the proposed snail-inspired biomimetic nozzle is significantly better than the circular nozzle since it reduces rod bundle vibration by increasing flow mixing. A 50% reduction was achieved by implementing it instead of the circular nozzle. More importantly, the shark-inspired nozzle delays the critical jet flow rate, at which the unstable vibration occurs in the rod bundle, by 20%. In addition to delaying instability, a vibration amplitude reduction of 87.5% was obtained using the proposed shark-inspired nozzle compared to the circular nozzle. The results are promising for various applications including gas burners, combustion chambers, and chemical reactors for providing efficient and rapid mixing between two fluid streams.
Spatio-temporal evolution of land use and its eco-environmental effects in the Caohai National Nature Reserve of China
Authors: Su Yin , Feng Guojun , Ren Jintong 
Published: November 2023

AbstractWith the rapid development of social economy, the ecological environment problems caused by the change of wetland land use have been widely concerned. This paper takes the Caohai National Nature Reserve (CNNR) of China as the research object on the basis of referring to previous research results. Firstly, the remote sensing data was employed to examine the spatio-temporal evolution process of the CNNR from three aspects: land use structure change, land use dynamic degree and land use space change. Then the change of ecological environment quality was studied from the greenness, the wetness, the dryness and the heat. Based on the spatiotemporal changes of land use types and ecological environment quality in the CNNR from 2000 to 2020, a comprehensive index, the remote sensing ecological index (RSEI), was constructed to analyze the ecological environmental effects of land use changes. The results indicate that the land use changes in the CNNR went through two major periods: first, a period of rapid decline in cultivated land, and second, a period of sharp increase in constructed land. During the period of rapid decline in cultivated land, the ecological environment quality in the study area showed an upward trend. However, during the period of increased constructed land, the ecological environment quality gradually stabilized. This study provides a basis for the coordinated development of the ecological environment and social economy in the CNNR area.
A disulfidptosis-related lncRNA index predicting prognosis and the tumor microenvironment in colorectal cancer
Authors: Xiao Lijun , Yin Wen , Chen Xuanqin , Zhang Xu , Zhang Chao , Yu Zehui , Lü Muhan 
Published: November 2023

AbstractColorectal cancer (CRC) is a common and deadly cancer worldwide with a high lethality rate. Disulfidptosis has been found to be an emerging mode of death in cancer, and the purpose of this study was to explore the relationship between disulfidptosis-related lncRNAs (DRLs) and CRC and to develop a prognostic model for CRC and DRLs. The gene expression data and clinicopathologic information of colorectal cancer patients were obtained from The Cancer Genome Atlas (TCGA) and screened for DRLs based on correlation analysis. The least absolute shrinkage and selection operator (LASSO) and Cox regression were used to construct the prognostic model, and its validation was carried out by PCA and receiver operating characteristic (ROC) curves. We constructed nomograms combined with the model. Finally, the possible mechanisms by which lncRNAs affect CRC were explored by functional enrichment analysis, immune infiltration and immune escape analysis. In summary, we developed a prognostic marker consisting of lncRNAs associated with disulfidptosis to help clinicians predict the survival of different CRC patients and use different targeted therapies and immunotherapies depending on the condition.