bluuebunny/crossref_metadata_2025_split huggingface dataset:
ISFO-CS: An Improved Sailfish Optimization Algorithm for Controller Selection in SDWSN
Authors: Rajoriya Manisha Kumari , Gupta Chandra Prakash 
Published: January 2024

Abstract

Software-defined wireless sensor networks (SDWSNs) have recently been added to networking, increasing scalability and performance. Choosing SDN controllers is a critical issue for network administrators in SDNs. The control plane in SDN is a separate procedure that operates on the control layer. In terms of applications and services, the controller provides a comprehensive view of the entire network. The three key factors examined when selecting a controller are open source, campus network, and productivity. An appropriate device for the prompt processing of all switch requests is required for SDN to function properly and the network to behave properly. To determine the optimum controller for the given parameters, decision logic that allows controller comparison must be developed. As a result, an improved Sailfish Optimization (ISFO) method is proposed in this study to ideally take the best controller node (CN) from a group of sensor nodes. The ISFO selects the best CN by considering a multi-objective fitness function incorporating distance, residual energy, node coverage, and sensor node communication cost. After selecting CN, the Fuzzy C-means (FCM) Clustering algorithm executes the subsequent data transmission process. The Matlab program is used to execute the simulation, and the performance of the proposed methodology is assessed using several performance criteria. The proposed model accomplishes a 0.95% packet delivery ratio for 500 rounds and takes 1.8s for 500 rounds of node to controller latency.
Ligand-functionalized Anderson-type Polyoxometalate for Efficient Selective Cationic Dye Adsorption
Authors: Kang Hongji , Yang Lili , Liu Yuqi , Su Ke , Zhang Hao , Huang Xiaoxue , Yang Lu 
Published: January 2024

Abstract
The issue of treating organic dyes in industrial wastewater has long been a subject of grave concern in the fields of environmental protection and public health. In an attempt to explore efficient solutions to this problem, this work focuses on the selective adsorption approach towards dyes molecules based on a Anderson-type polyoxometalate (POM, noted as POM-1) as potential adsorbent, which has been functionalized with organic groups. Adsorption experiments revealed that POM-1 displayed efficient adsorption capabilities towards the cationic dye methyl blue (MB) with almost complete adsorption within 25 min, and the adsorption rate was calculated as 98%. A rapid and consecutive filtering experiments have also been performed and further proved the excellent adsorption behavior of POM-1 towards MB. We envision that the functionalization of carboxylic ligands increased the negative charges of anionic POM, greatly promotes the interactions between adsorbent and cationic MB via electrostatic effect.
Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease
Authors: Zhang Xing-Jian , Liu Cong-Cong , Li Zuo-Lin , Ding Lin , Zhou Yan , Zhang Dong-Jie , Zhang Yao , Hou Shu-Ting , Ma Rui-Xia 
Published: January 2024

Abstract
Background
Tubulointerstitial fibrosis plays an important role in the progression of diabetic kidney disease (DKD). Sacubitril/valsartan (Sac/Val) exerts a robust beneficial effect in DKD. However, the potential functional effect of Sac/Val on tubulointerstitial fibrosis in DKD is still largely unclear.
Methods
Streptozotocin-induced diabetic mice were given Sac/Val or Val by intragastric administration once a day for 12 weeks. The renal function, the pathological changes of tubule injury and tubulointerstitial fibrosis, as well as mitochondrial morphology of renal tubules in mice, were evaluated. Genome-wide gene expression analysis was performed to identify the potential mechanisms. Meanwhile, human tubular epithelial cells (HK-2) were cultured in high glucose condition containing LBQ657/valsartan (LBQ/Val). Further, mitochondrial functions and Sirt1/PGC1α pathway of tubular epithelial cells were assessed by Western blot, Real-time-PCR, JC-1, MitoSOX or MitoTracker. Finally, the Sirt1 specific inhibitor, EX527, was used to explore the potential effects of Sirt1 signaling in vivo and in vitro.
Results
We found that Sac/Val significantly ameliorated the decline of renal function and tubulointerstitial fibrosis in DKD mice. The enrichment analysis of gene expression indicated metabolism as an important modulator in DKD mice with Sac/Val administration, in which mitochondrial homeostasis plays a pivotal role. Then, the decreased expression of Tfam and Cox Ⅳ, as well as changes of mitochondrial function and morphology, demonstrated the disruption of mitochondrial homeostasis under DKD conditions. Interestingly, Sac/Val administration was found to restore mitochondrial homeostasis in DKD mice and in vitro model of HK-2 cells. Further, we demonstrated that Sirt1/PGC1α, a crucial pathway in mitochondrial homeostasis, was activated by Sac/Val both in vivo and in vitro. Finally, the beneficial effects of Sac/Val on mitochondrial homeostasis and tubulointerstitial fibrosis was partially abolished in the presence of Sirt1 specific inhibitor.
Conclusions
Taken together, we demonstrate that Sac/Val ameliorates tubulointerstitial fibrosis by restoring Sirt1/PGC1α pathway-mediated mitochondrial homeostasis in DKD, providing a theoretical basis for delaying the progression of DKD in clinical practice.
Associations between Intake of Different Types of Vegetables and Metabolic Dysfunction- associated Fatty Liver Disease: A Population-based Study
Authors: Liu Chong , Liu Yubo , Liu Jie , Liu Jia , Lu Ting , Zhang Guogang , Xu Kai 
Published: January 2024

Abstract
Background
Metabolic dysfunction-associated fatty liver disease (MAFLD) presently poses a threat to approximately 24% of the global population. The consumption of healthy diets rich in an abundant assortment of vegetables has been scientifically validated to mitigate the progression of MAFLD. However, it remains uncertain whether all categories of vegetables confer benefits for MAFLD. The objective of this study is to investigate the impact of different types of vegetables on MAFLD, aiming to provide a scientific basis for developing more appropriate dietary recommendations for individuals at high risk of MAFLD.
Methods
We investigated the associations between various types of vegetable consumption and the risk of MAFLD, utilizing data sourced from the National Health and Nutrition Examination Survey (NHANES). Employing multiple logistic regression and subgroup analyses, we estimated odds ratios (ORs) and 95% confidence intervals (CIs).
Results
Our analysis encompassed a total of 3162 participants. Remarkably, heightened intake of dark green vegetables demonstrated an innovative association with reduced odds of MAFLD (OR = 0.50; 95% CI: 0.36–0.69; p-value < 0.01), while the consumption of starchy vegetables exhibited increased odds of MAFLD (OR = 1.39; 95% CI: 1.07–1.79; p-value = 0.02). In the subgroup analysis, a prominent inverse correlation between the consumption of dark green vegetables and MAFLD was discerned among female and non-Hispanic white people with higher educational attainment.
Conclusions
Our study conclusively demonstrates that a heightened intake of dark green vegetables is linked to diminished odds of MAFLD, whereas increased consumption of starchy vegetables is associated with elevated odds of MAFLD.
Whole-transcriptome and proteome analysis of active generalized vitiligo
Authors: Ge Kang , Zhao Yilu , Jin Hui-ling , Zhang Ru‐Zhi 
Published: January 2024

Abstract
To gain more insights into the transcriptomic landscape and molecular mechanism of vitiligo.
Methods: Data-independent acquisition mass spectrometry (DIA-MS) and whole-transcriptome sequencing (WTS) were performed on whole blood samples (WBS) from 3 patients with active generalized vitiligo (P-AGV) and from 3 healthy individuals (HIs). The gene-regulatory circuits, differentially expressed proteins (DEPs) and genes (DEGs), including mRNAs, miRNAs, lncRNAs and circRNAs, and enrichment analyses were comprehensively evaluated in P-AGV and HIs. The sequencing results were verified by quantitative real-time PCR (qRT-PCR) on 10 pairs of WBS from P-AGV and HIs.
Results: A total of 15 proteins and 669 genes were differentially expressed in P-AGV compared to HIs. Analysis of functional pathways showed that the DEPs and DEGs were only enriched in anegative regulation of muscle contraction. Bioinformatics analysis showed that hsa-miR-3613-3p, hsa-miR-511-5p and hsa-miR-6818-3p were involved in regulating the hub genes. The vital co-expression (lncRNA-mRNA, circRNA-mRNA) and rival endogenous RNA interaction axis demonstrated the potential roles of lncRNAs and circRNAs. Expression levels of 10 hub genes (apart from FCGR3B) were also confirmed by qRT-PCR analysis of 10 pairs of WBS.
Conclusions:This study provides valuable evidence for understanding the regulatory mechanisms of vitiligo and may contribute to the development of diagnostic and therapeutic targets.
Effect of Cobalt Ion Concentration and Thermal Annealing Temperature on Structural and Magnetic Properties of CoFe 2 O 4 nanoparticles
Authors: Shamkhi Ameer F. , Jabbar Hashim 
Published: January 2024

Abstract
Exploring physical properties of magnetic nanoferrites for applications in data storage media and biomedicine is a crucial step, providing new insights into the physics of nanostructured materials. Here, the focus is on studying the effect of cobalt ion concentration and thermal annealing temperature on structural and magnetic properties of cobalt ferrite (CoFe2O4) nanoparticles (NPs) synthesized using a co-precipitation method. To this end, Co1 − x(Fe2O4)x (x = 0.25, 0.5, and 0.75) NPs are initially prepared and then thermally annealed at different temperatures (T = 400 ºC–800 ºC). X-ray diffraction patterns along with field-emission scanning electron microscopic images indicate the formation of inverse cubic spinel structure with different crystallite sizes and NP size distributions when changing the cobalt ion concentration. Based on hysteresis loop measurements, magnetic parameters such as saturation magnetization (Ms) and coercivity (Hc) show increasing trends from 5.641 emu/g and 146.246 Oe to 8.936 emu/g and 1789.555 Oe when decreasing the cobalt ion concentration. By performing the annealing process, magnetic properties are significantly enhanced in the case of x = 0.25 and 0.5 at T = 400 ºC and 600 ºC, achieving Ms= 129.954 emu/g and Hc= 1137.697 Oe. Meanwhile, first-order reversal curve (FORC) diagrams are employed to map magnetostatic interactions and coercivity distributions as a function of cobalt ion concentration for NPs annealed at T = 400 ºC, manifesting magnetically soft and hard phases. It is found the maximum FORC distribution shifts to higher Hc values with decreasing the cobalt ion concentration.
Usability and preliminary effectiveness of an app-based physical activity and education program for people with hip or knee osteoarthritis – a pilot randomized controlled trial
Authors: Weber Franziska , Kloek Corelien , Stuhrmann Sandra , Blum Yannick , Grüneberg Christian , Veenhof Cindy 
Published: January 2024

Abstract
Background
Hip and knee osteoarthritis is highly prevalent worldwide. Guidelines recommend physical activity and education as the core treatment for osteoarthritis. Digital health has the potential to engage people in physical activity and disease management. Therefore, we conducted a pilot trial to assess the usability and the preliminary effectiveness of an app-based physical activity and education program (Join2Move) compared to usual care for people with hip and/or knee osteoarthritis in Germany.
Methods
A randomized controlled pilot study was conducted. Individuals with diagnosed or self-reported knee and hip osteoarthritis were included. Randomization was used for allocation in the intervention or control group. The intervention group received the Join2Move program. The Join2Move program was previously developed as a website and evaluated in the Netherlands. For the current study, the program was translated and adapted to the German context and adjusted from a website to an app. The control group received usual care. The primary outcomes were usability and preliminary effectiveness (pain and physical functioning). Measurements were taken at baseline and at twelve weeks. Data analysis was performed using SPSS (IBM SPSS Statistics 29.0).
Results
Sixty participants, with a mean age of 61.9 (SD ± 7.2) years, were allocated to the intervention (n = 32) or the control group (n = 28) and included in the analysis. The majority of participants had knee osteoarthritis (68%) and 12% had hip and knee osteoarthritis. The dropout rate was n = 11 (18%). No adverse events were reported. Usability was rated as acceptable (mean System Usability Scale = 71.3/100) with a wide range (32.5 to 100). Statistically significant between-group differences were found only for pain (mean difference 8.52 (95% CI 1.01 to 16.04), p = 0.027).
Conclusions
Join2Move demonstrated acceptable usability. The preliminary results of the pilot trial indicate the potential of a stand-alone app for the treatment of patients with hip or knee osteoarthritis. However, the acceptable usability of Join2Move limits its recommendation for everyone. There appears to be room for improvement in the app usability and in identifying patients for whom the app is suitable and the right time to use a stand-alone app for those patients.
Trial registration
German Clinical Trials Register DRKS00027164; https://drks.de/search/en/trial/DRKS00027164
Sign language recognition based on dual-path background erasure convolutional neural network
Authors: zhang junming , bu xiaolong , wang yushuai , Dong Hao , Wu Haitao 
Published: January 2024

Abstract
Sign language is an important way to provide expression information to people with hearing and speaking disabilities.Therefore, sign language recognition has always been a very important research topic. However, many sign language recognition systems currently require complex deep models and rely on expensive sensors, which limits the application scenarios of sign language recognition. To address this issue, based on computer vision, this study proposed a lightweight, dual-path background erasing deep convolutional neural network (DPCNN) model for sign language recognition. The DPCNN consists of two paths. One path is used to learn the overall features, while the other path learns the background features. Then, the background features are gradually subtracted from the overall features to obtain an effective representation of hand features. The proposed model achieved an accuracy of 99.52% on the ASL Finger Spelling dataset. More importantly, the proposed method can be applied to small terminals, thereby improving the application scenarios of sign language recognition. Through experimental comparison, the dual path background erasure network model proposed in this paper has better generalization ability.
Natural compound Byakangelicin suppresses breast tumor growth and motility by regulating SHP-1/JAK2/STAT3 signal pathway
Authors: Shi Xiuzhen , Lai Yuexing , Liu Wenjing , Zhang Xi , Cang Yanqin 
Published: January 2024

Abstract
These authors contributed equally to this work and should be considered co-first authors. Key Points ;Byakangelicin exerts anti-breast cancer effect in vitro. ;Byakangelicin inhibits growth and motility in breast cancer cells. ;Byakangelicin functions via blocking JAK2/STAT3 signal pathway in breast cancer cells. ;Byakangelicin impairs JAK2/STAT3 signal pathway via inducing SHP1. Abstract Byakangelicin is one of the furanocoumarins extracted from the root of Byakangelicin and has protective effect on liver injuryandfibrosis. In addition, Byakangelicin, as a traditional medicine, is also used to treat colds, headache and toothache. Recent studies have shown that Byakangelicin exhibits anti-tumor function; however, the role of Byakangelicin in breast tumor progression and related mechanism has not yet been elucidated. Our study aims to investigate the role of Byakangelicin in breast tumor progression and the underlying mechanism. Methods To measure the effect of Byakangelicin on JAK2/STAT3 signaling, a dual luciferase reporter assay and a western blot assay were performed. CCK8, colony formation, apoptosis and cell invasion assays were used to examine the inhibitory potential of Byakangelicin on breast cancer cells. Additionally, SHP-1 was silenced by specific siRNA duplex and the function of SHP-1 on Byakangelicin-mediated inhibition of JAK2/STAT3 signaling was evaluated. Results Byakangelicin treatment significantly inhibited STAT3 transcriptional activity. In addition, Byakangelicin treatment blocked JAK2/STAT3 signaling in a dose-dependent manner. Byakangelicin-treated tumor cells showed a dramatically reduced proliferation, colony formation and invasion ability. Moreover, Byakangelicin remarkedly induced breast cancer cell apoptosis. Furthermore, Byakangelicin regulated the expression of SHP1. Conclusion In conclusion, our current study indicated that Byakangelicin, a natural compound, inhibits SHP-1/JAK2/STAT3 signaling and thus blocks tumor growth and motility.
Effect of Different Edible Oil Coating and Storage Life on Post-harvest Quality of Banana Fruit
Authors: Asghar Muhammad , Khattak Abdul Mateen , Farooq Ahmad , Habib Waqas , Ahmad Shahbaz , Ahmed Manzoor 
Published: January 2024

Abstract
An experiment was carried out to study the “Effect of different edible oil coating and storage life on post-harvest quality of banana fruit” at Post harvest Laboratory, Department of Horticulture, The University of Agriculture Peshawar Pakistan during the year 2021. Banana fruit CV. Cavendish was obtained from local market Peshawar brought from Hyderabad during the month of April 2021 at physiological mature stage. The experiment was laid out using Completely Randomized Design (CRD) with two factors repeated two times. The fruits were then kept in packaging materials with one apple per bunch. When the fruits were ripened were divided into two groups, one group was coated with edible oil (olive, coconut and butter) and the other is storage life (0, 3, 6, 9, 12) and kept at room temperature 26 0 C at RH 90–95% for 12 days. The data regarding banana fruits coated with butter oil showed maximum fruit firmness, titratable acidity, ascorbic acid content, fruit color score, fruit taste score and fruit decay percentage. The maximum TSS was observed in banana fruit coated with olive oil. Regarding the other mean for storage duration maximum fruit firmness, minimum fruit decay and minimum TSS was recorded in freshly ripened banana fruits. While maximum test score, and color score observed in fruits stored for 12 days. Most of the studied attributes were significantly affected by T × SD interaction. It is concluded from the present results that banana fruits harvested at physiological maturity ripened under natural ripening agent i.e. apple, coated with butter oil retained most of the quality attributes for 12 days, is recommended for better shelf life and consumer preferences.
The relationship between self-perceived burden and facilitation of patient involvement in postoperative lung cancer patients: the mediating role of social support
Authors: Ren Na , Ma Fengyan , Tian Mengbai , Zhang Guochao , Xing Qi , Zheng Xu , Wu Wei , Qi Yimin , Wang Mingyu , Zhao Liang 
Published: January 2024

Abstract
Background
Lung cancer patients often experience high levels of self-perceived burden, which significantly impacts their quality of life and mental health. Social support is closely associated with self-perceived burden, but the relationship among social support, facilitation of patient involvement，and self-perceived burden remains unclear. This study aims to understand the current situationof self-perceived burden in postoperative lung cancer patients and to explore the mediating role of social support between facilitation of patient involvement and self-perceived burden.
Methods
A cross-sectional design was used in this study. Through a convenience sampling method, we invited 331 lung cancer patients hospitalized for surgical treatment at a specialized cancer hospital in Beijing, China, between August 2022 and May 2023 to participate in this survey. The questionnaire included a self-designed social demographic questionnaire, facilitation of patient involvement scale (FPIS), perceptive social support scale（PSSS）and patient self-perceived burden scale （SPBS）. SPSS 24.0 software was used for statistical description and Pearson correlation analysis, and AMOS 24.0 was used to build a structural equation model to test the mediation effect.
Results
The score of self-perceived burden in lung cancer patients was 26.42 ±8.23 points. Bot facilitation of patient involvement and social support was negatively correlated with self-perceived burden (r = -0.313, r = -0.332, P < 0.001). Social support plays partially mediated role in the relationship between facilitation of patient involvement and self-perceived burden, accounting for 44.3% of the total effect.
Conclusions
The self-perceived burden of patients after lung cancer surgery was at a moderate level, and social support partially mediates the relationship between facilitation of patient involvement and self-perceived burden. Medical staff should encourage patient participation in their own treatment decisions and alleviate the burden associated with lung cancer and surgical treatment by enhancing their social support.
3D Jade Carving Simulation Design and Image Virtual Technology Based on Light Sensing Texture Image Processing
Authors: Wang Sihan , Zhang Jie 
Published: January 2024

Abstract

In the process of economic development, special attention should be paid to controlling the ecological environment and promoting green and sustainable development. All objects or organisms in nature have surface structure, and structure is universal. It is also an important element in various visual clue images. Therefore, texture image classification plays an important role. In order to effectively extract the texture features of jade carving images, the researchers proposed several texture descriptors and applied them to the texture classification of jade carving images. Through the inheritance, arrangement, technological development and multi-disciplinary theoretical research of jade carving craftsmanship, this article believes that jade carving craftsmanship has exquisite craftsmanship, carries a large amount of culture, is a typical intangible cultural heritage, has a very high research price, and is used in different disciplines. Achievements have been made in the field. On this basis, the application of virtual technology in 3D jade carving simulation design is introduced in detail, and the design principle, technology platform, process flow and technology integration of this technology are explained, providing users with an immersive 3D jade carving simulation design. Platform, through real-time calculus to create a virtual world simulation system. Video images in image virtualization technology can represent complete spherical information and can be stored in storage media in the form of two-dimensional data, but it is easy to cause pixel distortion. Therefore, how to obtain the best image quality through sensor design is a research hotspot in this field. This paper conducts research from the aspects of non-virtual cultural heritage technology, interactive virtual jade carving technology, etc., as a platform to achieve the effects of "protection, display, dissemination, and education". Provide reference for non-cultural heritage.