bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyroptosis Induction with Nanosonosensitizer‐Augmented Sonodynamic Therapy Combined with PD‐L1 Blockade Boosts Efficacy against Liver Cancer
Authors: Zhang Nisi , Zeng Wenlong , Xu Yunxue , Li Rui , Wang Mengxuan , Liu Yijia , Qu Shuai , Ferrara Katherine W. , Dai Zhifei 
Published: November 2023

AbstractInduction of pyroptosis can promote anti‐PD‐L1 therapeutic efficacy due to the release of pro‐inflammatory cytokines, but current approaches can cause off target toxicity. Herein, a phthalocyanine‐conjugated mesoporous silicate nanoparticle (PMSN) is designed for amplifying sonodynamic therapy (SDT) to augment oxidative stress and induce robust pyroptosis in tumors. The sub‐10 nm diameter structure and c(RGDyC)‐PEGylated modification enhance tumor targeting and renal clearance. The unique porous architecture of PMSN doubles ROS yield and enhances pyroptotic cell populations in tumors (25.0%) via a cavitation effect. PMSN‐mediated SDT treatment efficiently reduces tumor mass and suppressed residual tumors in treated and distant sites by synergizing with PD‐L1 blockade (85.93% and 77.09%, respectively). Furthermore, loading the chemotherapeutic, doxorubicin, into PMSN intensifies SDT‐pyroptotic effects and increased efficacy. This is the first report of the use of SDT regimens to induce pyroptosis in liver cancer. This noninvasive and effective strategy has potential for clinical translation.
Over 240 Resonances on a Metasurface‐Pixelated Silicon Wafer in an Octave‐Spanning Terahertz Range
Authors: Liu Jiaming , Fang Xu , Lyu Wen , Deng Xiaojiao , Zheng Xiaoping 
Published: November 2023

AbstractMetasurfaces hold tremendous promise for various innovative sensing applications, thanks to their remarkable ability to manipulate light. A recent significant advancement in this research direction is using quasi‐BIC (bound states in the continuum) metasurfaces for mid‐infrared molecular sensing, which relies on creating a series of nearly uniformly spaced, sharp resonances on a single device. Although many studies have highlighted the potential of adopting this method in the terahertz (THz) regime, experimental demonstration is lacking. In this work, the first experimental demonstration of such frequency comb‐like, quasi‐BIC resonances on a single device is presented in the THz regime. By pixelating a 6‐inch Si wafer with 25 different metasurfaces that possess both high‐order quasi‐BIC modes and a geometric scaling, a set of 241 sharp resonances ranging from 350 to 750 GHz is produced based on numerical simulation. By using a high‐resolution vector network analyzer, 140 peaks that fall into the detection range from 500 to 750 GHz are confirmed experimentally, and their frequencies match well with the simulated results. By experimentally demonstrating frequency comb‐like, quasi‐BIC THz resonances on a single device, this work shows a new path for metasurface‐based sensing in the THz regime.
Rhodium‐Catalyzed Intramolecular Cyclization and Rearrangement of 1‐Azido‐2‐(2,2‐Dihalovinyl)arenes and 1‐Azido‐2‐[(2,2‐Dihalovinyl)(Boc)amino]arenes for the Preparation of 2,3‐Dihaloindoles and 2‐Haloquinoxalines
Authors: Abe Teppei , Kobayashi Kazuki , Kikukawa Seiya , Kanai Yuuki , Hata Takeshi 
Published: November 2023

AbstractTreatment of 1‐azido‐2‐(2,2‐dihalovinyl)arenes with a catalytic amount of Rh2(esp)2 afforded various 2,3‐dihaloindoles in 51–74% yields. This reaction progressed via the intramolecular cyclization of rhodium nitrene generated in situ and the rearrangement of one halogen group. For the 2‐chloro‐2‐iodovinyl group, the iodo group selectively rearranged to yield 2‐chloro‐3‐iodoindoles as single isomers. Moreover, 1‐azido‐2‐[(2,2‐dihalomovinyl)(Boc)amino]arenes were reacted with a catalytic amount of Rh2(oct)4, which produced 2‐haloquinoxaline in 55–92% yields.
Regioselective Organocatalyzed Monochlorination of Arenes with Electrophilic Chlorosulfoniums
Authors: Garay‐Talero Alexander , Acosta‐Guzmán Paola , Gamba‐Sánchez Diego 
Published: November 2023

AbstractThis manuscript presents a regioselective chlorination of arenes, yielding almost exclusively the monochlorinated product. It tolerates free hydroxy groups, 1°, 2° and 3° amines, and carboxylic acids, among other polar and nonpolar functional groups, as well as mono‐ and polysubstituted aromatic rings. Additionally, the utilization of chlorosulfonium salts as the chlorinating agent is demonstrated. The method emerges as an alternative to other processes where organic byproducts must be separated from the reaction mixture. In addition, the main byproducts are gaseous materials such as CO and CO2. This publication introduces the application of sulfoxides, oxalyl chloride, and aqueous hydrogen peroxide as the chlorination mixture.
Lactobacillus Intestinalis Primes Epithelial Cells to Suppress Colitis‐Related Th17 Response by Host‐Microbe Retinoic Acid Biosynthesis
Authors: Wang Qi‐Wen , Jia Ding‐Jia‐Cheng , He Jia‐Min , Sun Yong , Qian Yun , Ge Qi‐Wei , Qi Ya‐Dong , Wang Qing‐Yi , Hu Ying‐Ying , Wang Lan , Fang Yan‐Fei , He Hui‐Qin , Luo Man , Feng Li‐Jun , Si Jian‐Min , Song Zhang‐Fa , Wang Liang‐Jing , Chen Shu‐Jie 
Published: November 2023

AbstractGut microbiome is integral to the pathogenesis of ulcerative colitis. A novel probiotic Lactobacillus intestinalis (L. intestinalis) exerts a protective effect against dextran sodium sulfate‐induced colitis in mice. Based on flow cytometry, colitis‐associated Th17 cells are the target of L. intestinalis, which is supported by the lack of protective effects of L. intestinalis in T cell‐null Rag1−/− mice or upon anti‐IL‐17‐A antibody‐treated mice. Although L. intestinalis exerts no direct effect on T cell differentiation, it decreases C/EBPA‐driven gut epithelial SAA1 and SAA2 production, which in turn impairs Th17 cell differentiation. Cometabolism of L. intestinalis ALDH and host ALDH1A2 contributed to elevated biosynthesis of retinoic acid (RA), which accounts for the anti‐colitis effect in RAR‐α ‐mediated way. In a cohort of ulcerative colitis patients, it is observed that fecal abundance of L. intestinalis is negatively associated with the C/EBPA‐SAA1/2‐Th17 axis. Finally, L. intestinalis has a synergistic effect with mesalazine in alleviating murine colitis. In conclusion, L. intestinalis and associated metabolites, RA, have potential therapeutic effects for suppressing colonic inflammation by modulating the crosstalk between intestinal epithelia and immunity.
Photonic Physical Reservoir Computing with Tunable Relaxation Time Constant
Authors: Yamazaki Yutaro , Kinoshita Kentaro 
Published: November 2023

AbstractRecent years have witnessed a rising demand for edge computing, and there is a need for methods to decrease the computational cost while maintaining a high learning performance when processing information at arbitrary edges. Reservoir computing using physical dynamics has attracted significant attention. However, currently, the timescale of the input signals that can be processed by physical reservoirs is limited by the transient characteristics inherent to the selected physical system. This study used an Sn‐doped In2O3/Nb‐doped SrTiO3 junction to fabricate a memristor that could respond to both electrical and optical stimuli. The results show that the timescale of the transient current response of the device could be controlled over several orders of magnitude simply by applying a small voltage. The computational performance of the device as a physical reservoir is evaluated in an image classification task, demonstrating that the learning accuracy could be optimized by tuning the device to exhibit appropriate transient characteristics according to the timescale of the input signals. These results are expected to provide deeper insights into the photoconductive properties of strontium titanate, as well as support the physical implementation of computing systems.
Blood flow ratio in the gastric conduit measured by laser Doppler flowmetry: A predictor of anastomotic leakage after esophagectomy
Authors: Ishida Hirotaka , Fukutomi Toshiaki , Taniyama Yusuke , Sato Chiaki , Okamoto Hiroshi , Ozawa Yohei , Onodera Yu , Koseki Ken , Unno Michiaki , Kamei Takashi 
Published: November 2023

AbstractBackgroundAnastomotic leakage after esophagectomy is a common complication. Laser Doppler flowmetry (LDF) can quantitatively evaluate the blood flow in the gastric conduit.MethodsA total of 326 patients who underwent thoracoscopic/robot‐assisted esophagectomy followed by gastric conduit reconstruction and end‐to‐side anastomosis were enrolled. We divided the gastric conduit into zones I (dominated by the right gastroepiploic vessels), II (dominated by the left gastroepiploic vessels), and III (perfused with short gastric vessels). Before pulling up the gastric conduit to the neck, LDF values were measured at the pylorus, the border between zones I and II (zone I/II), the border between zones II and III (zone II/III), and the gastric conduit tip (tip). The blood flow ratio was calculated as the LDF value divided by the LDF value at the pylorus.ResultsAnastomotic leakage developed in 32 of 326 patients. Leakage was significantly associated with the blood flow ratio at the tip (p < 0.001), but not at zone I/II, zone II/III, and the anastomotic site. The receiver‐operating characteristic curve analysis identified an anastomotic leakage cutoff ratio of 0.41 (at the tip). A multivariate Cox analysis showed that a blood flow ratio <0.41 at the tip was an independent risk factor for anastomotic leakage (p < 0.001).ConclusionAnastomotic leakage after esophagectomy was significantly associated with the blood flow ratio at the tip of the gastric conduit. Preservation of the blood supply to the tip via the gastric wall might contribute to a decreased incidence of anastomotic leakage.
Sembrando Semillas, sowing seeds: Reflections on Latinx representations in US community psychology's AJCP
Authors: Fernández Jesica Siham , Bernal Ireri , Guzmán Bianca L. 
Published: November 2023

AbstractLatinx have contributed to the foundation and formation of the United States, and as this demographic increases, overlooking their unique experiences and lived conditions can limit community psychology's potential to better support them in their wellbeing. Thus, in alignment with the call for a virtual special issue highlighting critical themes in the American Journal of Community Psychology (AJCP), we take an exemplar approach to reviewing 15 articles published between 1979 and 2023. We highlight these articles for their unique contributions in laying the foundation or shifting the discourses of Latinx in the United States. We organize each article under one of the following themes: (1) Challenging notions of Latinx as passive victims or deficient; (2) Documenting the misrepresentation and invisibility of Latinx in community psychology; (3) Affirming Latinx as knowledge producers, protagonists, and agents of change; and (4) Centering Latin American epistemologies that foster liberatory praxis for and with Latinx. Via these themes, we illustrate where the discipline has been, and offer reflection for where it can move toward as it relates to Latinx. In doing so, we highlight perspectives grounded in Latinx communities. Our review is not exhaustive; however, it offers our subjective interpretation or curation of the articles we acknowledge as fundamental to the discipline's formation, and our learning and ongoing growth as critical community psychologists of Latin American heritage with affinities to Latinx communities in the United States. We offer this brief review as a semilla (seed) to the possibilities ahead as we remain open to reflection, dialog and learning.
Novel technique for ultrasound‐guided needle tracking: An inexpensive reusable phantom model utilising a closed electrical circuit
Authors: McKinley Hillary J. , Jones Isaak , LaRochelle Madeline , Christensen Erik , Bauman Weeden , Croft Peter 
Published: November 2023

AbstractPurposePurpose:There are a variety of commercially made ultrasound training phantoms available for educational purposes. A new concept in phantoms is presented that utilises a low‐cost method to create a reusable phantom.MethodsA closed electric circuit was combined with insulating material to create a novel phantom that can be used to practise needle tracking under ultrasound guidance on repeated occasions. A tricolour light‐emitting diode (LED) illuminates when the needle (under ultrasound gudiance) contacts one of three metal objects embedded in the phatom material.ConclusionThis prototype model provides a simple solution for trianing ultrasound needle guidance is particularly geared towards programmes with a high volume of users. This protoype provides a starting point for a new concept in educational phantom trainers.
Enhancing the production of recombinant human TGF‐β1 through an understanding of TGF‐β1 synthesis, signaling, and endocytosis in CHO cells
Authors: Kim Kyungsoo , Kim Young Sik , Jang Ju Woong , Lee Gyun Min 
Published: November 2023

AbstractTo enhance the production of recombinant human transforming growth factor‐beta1 (rhTGF‐β1) in Chinese hamster ovary (CHO) cells, rhTGF‐β1 was first characterized for endocytosis, signaling pathway, and overall maturation process. The mature rhTGF‐β1 used for clinical application was internalized into CHO cells and inhibited the growth of CHO cells in a dose‐dependent manner. However, mature rhTGF‐β1 was mostly produced in the form of latent rhTGF‐β1 in cultures of recombinant CHO (rCHO) cells producing rhTGF‐β1 (CHO‐rhTGF‐β1). The concentration of active mature rhTGF‐β1 in the culture supernatant of CHO‐rhTGF‐β1 cells was not high enough to compromise yield. In addition, a significant amount of unprocessed precursors was produced by CHO‐rhTGF‐β1 cells. Overexpression of PACEsol, a soluble form of furin, in CHO‐rhTGF‐β1 cells was effective for the proteolytic cleavage of unprocessed precursors. The highest mature rhTGF‐β1 concentration (6.4 μg mL−1) was obtained with the PACEsol‐expressing clone, which was approximately 45% higher than that of the parental clone (P < 0.01). Thus, a comprehensive understanding of the intrinsic properties of rhTGF‐β1 with respect to the overall maturation process, signaling pathway, and endocytosis is essential for effectively enhancing the production of mature rhTGF‐β1 in CHO cells.
Floral Visitation, Phytochemical and Biological Activities of Bioproducts from Tetragonisca angustula (Hymenoptera, Apidae, Meliponini): A Review
Authors: Silva Macêdo Nair , de Sousa Silveira Zildene , da Silva Sousa Ângella Eduarda , Menezes Dantas Débora , Bispo Monteiro Amanda Lins , Silva dos Santos Helcio , Bezerra da Cunha Francisco Assis 
Published: November 2023

AbstractTetragonisca angustula (Latreille, 1811) is an indigenous neotropical stingless bee, popularly known as “Jataí”, with a wide distribution in the Brazilian territory. T. angustula produces other derivatives such as propolis, geopropolis, fermented (saburá pollen), cerumen and resins, which are important in folk medicine. In this review, the objective was to gather research on the main plant species visited by T. angustula, as well as studies that verified the chemical composition and biological properties of T. angustula bioproducts. The bibliographic review was performed by searching the Scopus, Web of Science, ScienceDirect, and PubMed databases for publications from 2003 to February 2023. We found 78 studies that analyzed the interactions between T. angustula and floral species, with species from the botanical families Fabaceae, Asteraceae, Malvaceae, Bignoniaceae, Solanaceae, Myrtaceae and Lamiaceae being the most reported as the main food sources for this species. The presence of compounds belonging to the class of flavonoids, phenolic acids, terpenoids and alkaloids has been identified by studying the chemical composition of honey, propolis, geopropolis and fermented pollen (saburá) in 21 studies. The data collected in the literature emphasize that these T. angustula products have remarkable biological properties, especially their antibacterial and antioxidant activities.
Bioequivalence of 240 mg Apalutamide Tablets and Preparation in Aqueous Food Vehicles for Alternative Administration
Authors: Yu Alex , Van Uffel Mieke , Jiao Juhui J. , Rosales Rosamerlinda , Erba Maura , Haddish‐Berhane Nahor 
Published: November 2023

AbstractA 240‐mg single tablet has been developed with the focus of reducing the pill burden of the apalutamide daily dose of 240 mg (4 × 60‐mg tablets). An open‐label, randomized, single‐dose phase 1 study with a 2‐sequence and 2‐period crossover design in healthy men determined the bioequivalence of a 240‐mg single tablet versus the currently available 4 × 60‐mg tablets (Part 1, N = 74) and assessed effect of a high‐fat meal (Part 2, N = 21) on apalutamide maximum plasma concentration (Cmax) and the area under the plasma concentration‐time curve (AUC0‐72 h). The 90% confidence interval of geometric mean ratios for Cmax and AUC0‐72 h fell between 80% and 125% for both Part 1 and Part 2. No new safety concerns with the 240‐mg single tablet were observed. To support the use of different food vehicles as well as nasogastric (NG) tubes for alternative administration, we conducted in vitro compatibility studies to evaluate the purity, dose, and stability of 240‐mg tablets dispersed in applesauce/yogurt/orange juice/green tea as well as in NG tubes (polyurethane/silicone/polyvinyl chloride). The studies confirmed the alternative administrations do not affect the purity, dose‐accuracy, or stability of apalutamide. The apalutamide 240‐mg tablet is bioequivalent to 4 × 60‐mg tablets and compatible with the tested food vehicles and NG tubes.
Does Confucian culture reduce firms' pollution emissions
Authors: Cao Kairui , Jiang Weijie , Jin Laiqun , Zhu Yuanyuan 
Published: November 2023

AbstractThis paper explores the influence of Confucian culture on firms' emissions. We measure Confucian culture during the Ming and Qing dynasties using the density of jinshi in that region and test the causal relationship between Confucian culture and firms' emissions using the Annual Survey of Industrial Firms (ASIF) and China's Environmental Statistics Database (CESD) from 1998 to 2013. Our research reveals that regions with a stronger Confucian cultural influence have a significant reduction in pollution emissions from their firms. Further analysis demonstrates that the government in regions with a strong Confucian cultural influence attaches more importance to environmental protection and enforces stricter environmental regulations on firms. Besides, the people demonstrate heightened environmental awareness, incorporating it into economic development, thus reducing firms' pollution emissions. In addition, Confucian culture can reduce pollution emissions by improving the total factor productivity of firms.
Environmental innovation in healthcare industry: The moderating role of women on board in cost of debt
Authors: Romano Mauro , Netti Antonio , Corvino Antonio , Intenza Marika 
Published: November 2023

AbstractOver recent years, a growing body of empirical evidence highlights a positive correlation between ecological innovation and firm value creation. Building on natural resource‐based view and upper echelons theory, this study examines the relationship between environmental innovation and the cost of debt, by verifying whether and to what extent there is a moderation effect due to the board gender diversity. Using a sample of 458 European firms belonging to the healthcare industry, we carried out a cross‐sectional analysis, given that the sample is based on just the fiscal year 2020. The empirical evidence shows that environmental innovation decreases the cost of debt, by reducing company's perceived risk. In addition, board gender diversity negatively moderates the foregoing relationship. Therefore, our study suggests that public policy makers might underpin environmental innovation policies and specific features on board of directors, since they exert relevant implications on firm's value creation and investors' decisions.
Simplified three‐phase split‐source inverter for PV system application controlled via model‐predictive control
Authors: Elthokaby Youssuf , Abdelsalam Ibrahim , Abdel‐Rahim Naser , Mohamed Islam 
Published: November 2023

SummaryIn this paper, for standalone and grid‐connected PV systems, a three‐phase simplified split‐source inverter (SSI) is proposed and controlled using a model‐predictive control (MPC). The maximum power point tracking (MPPT) approach used is an incremental conductance method based on a PI controller for both systems. The standalone system is composed of PV modules, a three‐phase SSI, and a bidirectional power DC–DC converter that connects a battery bank and a DC‐side capacitor. The output AC voltages of SSI are controlled using MPC. The bidirectional power DC–DC converter regulates the DC‐link voltage (DCLV). The grid‐connected system consists of PV modules, a three‐phase SSI, and an AC‐side L‐filter. The DC‐link PI controller generates reference currents for the MPC algorithm. The MPC uses these reference currents to adjust and deliver the PV power to the grid while regulating the DCLV. The PI controllers' parameters are selected for both systems using the Harris Hawks optimization method. Both PV systems simulation results show that under various operating conditions, they have succeeded in fixing a DCLV and producing a high‐quality AC output voltage and current at low THD. Experimental results for the three‐phase standalone PV system used to verify the system's performance.
The formation of language teacher identity: A narrative inquiry of an EFL teacher's ER implementation
Authors: Sun Xiaomei , Akbar Farah 
Published: November 2023

AbstractThis narrative inquiry investigates an English as a Foreign Language teacher's storied experience of 30‐year extensive reading (ER) implementation, with the aim of exploring the formation of language teacher identity (LTI) of this individual teacher. Two narrative interviews were conducted, respectively focusing on the holistic story and detailed accounts of some critical incidents and significant others. Two researchers played different roles: one insider, conducting, transcribing, translating, and analysing interviews; one outsider, analysing the data with a relatively neutral perspective. Data analysis adopted an ecological approach and a three‐level framework (societal, interpersonal, and intrapersonal levels). Findings highlight the complex links between discursive features, personal experience, teacher emotions, and power differentials in shaping the dynamic and multi‐faceted nature of LTIs. Meanwhile, the considerable evolution of the teacher's ER implementation validates the importance of teacher training, especially opportunities for teachers to gain experiential knowledge which further contributes to teacher identity development.