bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interatrial defect sizing by intracardiac and transesophageal echocardiography compared with fluoroscopic measurements in patients undergoing percutaneous transcatheter closure
Authors: Boccalandro Fernando , Muench Andreas , Salloum Joseph , Awadalla Hany , Carter Catherine , Barasch Eddy , Smalling Richard W. 
Published: June 2004

AbstractThe purpose of this study was to evaluate prospectively the feasibility and accuracy of using echocardiographic measurements by transesophageal and intracardiac echocardiography (TEE and ICE, respectively) for interatrial septal defect sizing during percutaneous transcatheter closure. Forty‐two patients underwent balloon sizing of interatrial septal defects using TEE in 21 of them and ICE in the other half. These measurements were correlated with quantitative fluoroscopic analysis and evaluated for bias and agreement between methods using a Bland‐Altman analysis. Echocardiographic measurements were obtained by ICE and TEE in all patients. An excellent correlation was found between TEE and quantitative fluoroscopy (r = 0.898; P < 0.001) and between ICE and quantitative fluoroscopy (r = 0.876; P < 0.001), with a significant agreement (P < 0.001) and minimal positive bias toward the echocardiographic measurements. Both TEE and ICE are excellent methods of interatrial defect sizing when compared with quantitative fluoroscopic measurements. Catheter Cardiovasc Interv 2004;62:415–420. © 2004 Wiley‐Liss, Inc.
Overlapping vs. one long stenting in long coronary lesions
Authors: Lee Sang Hak , Jang Yangsoo , Oh Sung Jin , Park Kyeong Jin , Moon Yong Sun , Min Ja Won , Yang Joo Young , Jang Gil Jin 
Published: June 2004

AbstractIntervention of long coronary lesions remains problematic, and optimal treatment strategy is yet to be determined. Despite advancement of stent technology, data are few regarding the efficacy of overlapping stents vs. a single long stent in long coronary lesions. This study was performed to evaluate the results of those strategies for long coronary lesions and to determine the predictors of in‐stent restenosis (ISR). Sixty‐four lesions (> 20 mm) in 64 patients were treated with either one long stent (group 1, n = 32) or two overlapping stents (group 2, n = 32). Overlapping stents were used at tortuous or calcified lesions and at lesions with diameter discrepancy or significant dissection. Immediate results, follow‐up clinical and angiographic outcomes, and predictors of ISR were evaluated. Procedures were successful in all patients in both groups. Clinical and angiographic follow‐ups were performed in 54 (84%) cases and 50 (78%) cases, respectively. During the follow‐up, major adverse cardiac event occurred in 36% of group 1 and 29% of group 2 (P = 0.56). Six‐month ISR rates were 39% in group 1 and 41% in group 2 (P = 0.91). Age (≥ 65 years old) was an independent risk factor of ISR (54% vs. 23%; OR = 4.4; P = 0.04), and distal reference diameter (RD) of less than 2.5 mm tended to predict ISR in multivariate analysis (60% vs. 25%; OR = 3.5; P = 0.06). In conclusion, stent overlapping can be used with outcome similar to that of one long stent in long coronary lesions. The optimal result may be obtained by considering the patient's age and the distal vessel diameter of the lesion. Catheter Cardiovasc Interv 2004; 62:298–302. © 2004 Wiley‐Liss, Inc.
Concomitant coronary and multiple arch vessel stenoses in patients treated with external beam radiation: Pathophysiological basis and endovascular treatment
Authors: Cavendish Jeffrey J. , Berman Brett J. , Schnyder Guido , Kerber Charles , Mahmud Ehtisham , Turi Zoltan G. , Blanchard Daniel , Tsimikas Sotirios 
Published: June 2004

AbstractExternal beam radiation‐induced stenoses isolated to the coronary arteries or peripheral vessels have been previously described. We report for the first time the clinical presentation of two patients with concomitant coronary artery and multiple arch vessel disease following external beam radiation of the chest. We review the pathophysiology, discuss the treatment options and describe the percutaneous treatment of coronary, carotid, subclavian, and axillary stenoses related to this rare but likely underdiagnosed disorder. Catheter Cardiovasc Interv 2004;62:385–390. © 2004 Wiley‐Liss, Inc.
Corrosion of tungsten coils after peripheral vascular embolization therapy: Influence on outcome and tungsten load
Authors: Bachthaler Maike , Lenhart Markus , Paetzel Christian , Feuerbach Stefan , Link Johann , Manke Christoph 
Published: June 2004

AbstractThe purpose of this study was to evaluate coil corrosion and the long‐term outcome after peripheral vascular embolization therapy performed with tungsten coils. We studied 14 patients who received tungsten coils on an average of 26 months prior to follow‐up. The protocol included plain radiography and contrast‐enhanced magnetic resonance angiography to investigate corrosion of tungsten coils and recanalization of the embolized vessels. Whole blood, hair, and urine tungsten levels were assayed when available. Corrosion of tungsten coils was detected in 9 of 14 patients by plain radiography. No evidence of recanalization of the embolized vessel and no adverse clinical effects of tungsten resorption were detected. Blood levels of tungsten were elevated in 6 of 14 patients and urine levels of tungsten were elevated in all 12 patients tested. Tungsten coil corrosion and elevated tungsten levels in blood, hair, and urine were found in most patients, although no adverse clinical effects of tungsten resorption were detected. Since the overall effect of high tungsten blood levels remains unclear, its use as an implant should be avoided. Catheter Cardiovasc Interv 2004;62:380–384. © 2004 Wiley‐Liss, Inc.
Crush stenting of bifurcational left subclavian‐vertebral artery stenosis
Authors: Roguin Ariel , Alhaddad Imad A. 
Published: June 2004

AbstractLeft internal mammary artery (LIMA) has the best long‐term patency in patients undergoing coronary artery bypass surgery. Stenosis of the proximal left subclavian artery (SA) may reduce flow to the LIMA, causing myocardial ischemia. We report a novel technique (crush stenting) for the treatment of a complex bifurcational left SA‐vertebral artery (VA) stenosis in the presence of a patent LIMA bypass conduit. This technique limited plaque shifting, restored normal flow to all vessels, including the LIMA, and avoided devastating consequences of VA occlusion. Catheter Cardiovasc Interv 2004;62:393–395. © 2004 Wiley‐Liss, Inc.
Mutational spectra of p53 in geographically localized esophageal squamous cell carcinoma groups in China
Authors: Cao Wei , Chen Xufeng , Dai Huifang , Wang Huizhen , Shen Binghui , Chu David , McAfee Taylor , Zhang Zuo‐Feng 
Published: June 2004

AbstractBACKGROUNDEsophageal carcinoma is a particularly interesting tumor because of the dramatic difference in its incidence and geographic distribution among populations of similar ethnic origin. Epidemiologic data have suggested that many environmental exposures may be associated with an increased risk of its formation.METHODSIn this study, 92 samples of esophageal squamous cell carcinoma (ESCC) were collected from patients who resided in 2 geographic areas in China with different incidences of ESCC: Linxian and Zhejiang. Overexpression and mutations of the p53 tumor‐suppressor gene were examined by using immunohistochemistry, single‐strand conformation polymorphism analysis, and direct sequencing.RESULTSThe rates of point mutation and overexpression of p53 in the ESCC specimens studied were 30.4% (29 of 92 specimens) and 51.1% (47 of 92 specimens), respectively. The overexpression of p53 was associated with tumor metastasis and with 5‐year case fatality. Significant differences were found in the rates of overexpression and mutations in patients with clinical T2 tumors between the specimens from Linxian, which is a high‐incidence geographic area, and the specimens from Zhejiang, which is a low‐incidence area. Furthermore, different mutational spectra were found in the tumor samples from these two geographic areas: In tumor samples from Linxian, the most common substitution mutation was a transversion in exon 5, whereas the most common mutations in tumor samples from Zhejiang were transitions in exon 7.CONCLUSIONSThe data suggest that the mutation and overexpression of p53 may play important roles in the development of ESCC. The changes in p53 may reflect environmental exposure to the different combinations of mutagenic factors and genetic instability demonstrated by the populations in Linxian and Zhejiang. The overexpression of p53 protein may have significance as a prognostic factor for patients with esophageal carcinoma. Cancer 2004. © 2004 American Cancer Society.
Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII‐null thymus
Authors: Moon Eun‐Yi , Han Ying Hao , Lee Dong‐Seok , Han Yong‐Mahn , Yu Dae‐Yeul 
Published: June 2004

AbstractIn the thymus, CD4+ or CD8+ single‐positive (SP) thymocytes develop and mature by positive and negative selection or undergo ‘death by neglect’. CD4+ or CD8+ SP then circulate to other lymphoid tissues. We have investigated the role of reactive oxygen species (ROS) in thymocyte development using peroxiredoxin II (PrxII)‐null mice. The level ofROS in PrxII‐null thymocytes is higher than that in wild‐type mice. Deletion of the PrxII gene leads to enlargement of the thymus in young (9 weeks) and old (64 weeks) mice. The increased number ofthymocytes in PrxII‐null thymus is related to reduced hypodiploid cell formation. For mice on a normal diet, the ratio of SP to double‐positive (DP) thymocytes in thymus of PrxII‐null mice is lower thanthat in wild‐type mice. After food restriction, which leads to increased ROS production, this ratio becomes much higher in PrxII‐null thymus. The amount of apoptosis, induced by food restriction orby the injection of dexamethasone, is consistently lower in PrxII‐null thymocytes than in wild‐type thymocytes. In the presence of low serum concentrations, PrxII‐deleted T cells proliferate more vigorously after stimulation with concanavalin A. Phytohemagglutinin‐ or OKT3‐stimulated proliferation of human peripheral blood mononuclear cells is also higher in the presence of lower serum concentrations. Collectively, the results suggest for the first time that thymocyte maturations and proliferations are regulated by ROS levels induced by the deletion of PrxII gene in vivo.
Molecular, One‐ and Two‐Dimensional Systems Built from Manganese(II) and Phthalate/Diimine Ligands: Syntheses, Crystal Structures and Magnetic Properties
Authors: Ma Chengbing , Wang Wenguo , Zhang Xiaofeng , Chen Changneng , Liu Qiutian , Zhu Hongping , Liao Daizheng , Li Licun 
Published: June 2004

AbstractSeveral new MnII compounds, [Mn2(Hphth)2(phen)4](Hphth)2·2H2O (1; H2phth = phthalic acid, phen = 1,10‐phenanthroline), [Mn2(Hphth)2(phen)4](ClO4)2·2H2O (2), [Mn4(phth)4(phen)4(H2O)4]·2EtOH (3), {[Mn4(phth)2(phen)8](PF6)4}2 (4), [Mn4(phth)2(bipy)8](ClO4)4·2EtOH (5; bipy = 2,2′‐bipyridine), [Mn(phth)(bipy)(H2O)2]n (6), and [Mn(phth)(pyz)(H2O)2]n (7; pyz = pyrazine), have been synthesized by treatment of the appropriate Mn2+ salt and H2phth with different diimine ligands. They were characterized by X‐ray diffraction and show a variety of nuclearities, ranging from dinuclear (1 and 2) to tetranuclear (3−5), and dimensionalities, ranging from a 1D chain (6) to a 2D layer network (7), in which the phthalates act as primary bridging ligands coordinating to Mn atoms through their carboxylate groups in various bonding modes. Variable‐temperature magnetic susceptibility measurements reveal weak anti‐ferromagnetic coupling interactions in 1, 3, 4 and 6. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Body Image Self‐evaluation Colouring Lens: comparing the ornamental and instrumental views of adolescent girls with eating disorders
Authors: Gusella Joanne , Clark Sharon , van Roosmalen Erica 
Published: June 2004

AbstractA new visual measure of body image, the Body Image Self‐evaluation Colouring Lens (BISCL), was used to examine how 22 girls with diagnosed eating disorders evaluated their bodies. Results revealed that the percent of negative body evaluation was significantly higher when girls evaluated their body form as compared to their body function. Girls expressed new insights when comparing their relatively positive evaluation of their body functioning to their generally negative view of their body appearance. They expressed dissatisfaction with body parts that did not conform to their current cultural ideals. The BISCL was correlated in a predictable manner with standardized measures of body dissatisfaction. The promising applications of the BISCL as a clinical and research tool are discussed. Copyright © 2004 John Wiley & Sons, Ltd and Eating Disorders Association.
A longitudinal study of the relationship between body image, self‐esteem and dieting among 15–21 year olds in Norway
Authors: Friestad Christine , Rise Jostein 
Published: June 2004

AbstractPurposeThe study investigates the predictive value of body image, self‐esteem and gender for adolescent dieting at ages 15, 18 and 21 and whether adolescents' self‐esteem moderates the relationship between body image and dieting.MethodData stem from the Norwegian Longitudinal Health Behaviour Study (NLHB study): Adult by the Year 2000 (‘Voksen i år 2000’). The NLHB study is a 10‐year prospective cohort study based on self‐completed questionnaires investigating health behaviour and lifestyle patterns among Norwegian adolescents. This paper presents data from Wave II (1992), Wave IV (1995) and Wave VI (1998), thus covering the ages 15, 18 and 21. Analyses are based on the 487 respondents participating at all three timepoints.ResultsAt all ages included, 25% of the girls reported they had dieted several times over the past year, while the corresponding figure for boys was 5%. Among boys, self‐esteem and body image contributed to the same extent in the prediction of dieting, while only body image proved a significant predictor among girls, increasing in importance over time. Interaction between self‐esteem and body image was present among young boys (ages 15 and 18) only.ConclusionsSelf‐esteem and body image play quite different roles in the prediction of dieting among girls and boys. The difference is not only related to strength of association between the variables, but, more importantly, to qualitatively different underlying processes. Copyright © 2004 John Wiley & Sons, Ltd and Eating Disorders Association.
Brain–behavior correlation in children depends on the neurocognitive network
Authors: Booth James R. , Burman Douglas D. , Meyer Joel R. , Trommer Barbara L. , Davenport Nicholas D. , Parrish Todd B. , Gitelman Darren R. , Mesulam M. Marsel 
Published: June 2004

AbstractWe examined brain–behavior correlations in 12 children (age range 9.3 to 11.7 years) during a selective attention task that required the visual search of a conjunction of features and during a response inhibition task that required the inhibition of a pre‐potent response during “no‐go” blocks. We found that the association between performance in these tasks and brain activation as measured by functional magnetic resonance imaging (fMRI) depended on the neurocognitive network. Specifically, better performance during the no‐go task was associated with greater activation in the response inhibition network including the prefrontal cortex and basal ganglia. In contrast, better performance during the visual search task was associated with less activation in the selective attention network including superior parietal lobule and lateral premotor cortex. These results show that the relation of performance to the magnitude of neural activation is complex and may display differential relationships based on the cognitive domain, anatomical region, and perhaps also developmental stage. Hum Brain Mapping 23:99–108, 2004. © 2004 Wiley‐Liss, Inc.
Enhancement of the p27Kip1‐mediated antiproliferative effect of trastuzumab (Herceptin) on HER2‐overexpressing tumor cells
Authors: Marches Radu , Uhr Jonathan W. 
Published: June 2004

AbstractThe oncogenic activity of the overexpressed HER2 tyrosine kinase receptor requires its localization in the plasma membrane. The antitumor effect of anti‐HER2 antibodies (Abs) is mainly dependent on receptor downregulation and comprises p27Kip1‐mediated G1 cell cycle arrest. However, one major limitation of anti‐HER2 therapy is the reversibility of tumor growth inhibition after discontinuation of treatment caused by the mitogenic signaling associated with cell surface receptor re‐expression. We found that the level of p27Kip1 upregulation, inhibition of Cdk2 activity and magnitude of G1 arrest induced by the humanized Ab trastuzumab (Herceptin, HCT) on BT474 and SKBr3 HER2‐overexpressing breast cancer cells correlates with the level of cell surface receptor. Thus, continuous exposure of cells to HCT for 72 hr results in downregulation of the cell surface receptor and a concurrent increase in the level of p27Kip1 protein. Discontinuation of Ab exposure after the first 8 hr results in failure to upregulate p27Kip1 and arrest of cell cycle progression. We show that the lysosomotropic amine chloroquine (CQ) augments receptor internalization in HER2‐overexpressing cells either pretreated or continuously treated with HCT and leads to an increased and sustained inhibitory effect. The enhanced CQ‐dependent loss of functional HER2 from the cell surface resulted in sustained inactivation of the serine/threonine kinase Akt, upregulation of p27Kip1 protein and inhibition of cyclin E/Cdk2 activity. Potentiation of the inhibitory effect of HCT by CQ was directly related to loss of HER2 from the plasma membrane since prevention of Ab‐mediated receptor endocytosis by engagement of the receptor with immobilized HCT abrogated the effect of CQ. © 2004 Wiley‐Liss, Inc.
Dissecting progressive stages of 5‐fluorouracil resistance in vitro using RNA expression profiling
Authors: Schmidt Wolfgang M. , Kalipciyan Maria , Dornstauder Eva , Rizovski Blanka , Steger Guenther G. , Sedivy Roland , Mueller Manfred W. , Mader Robert M. 
Published: June 2004

AbstractResistance to anticancer drugs such as the widely used antimetabolite 5‐fluorouracil (FU) is one of the most important obstacles to cancer chemotherapy. Using GeneChip arrays, we compared the expression profile of different stages of FU resistance in colon cancer cells after in vitro selection of low‐, intermediate‐ and high‐resistance phenotypes. Drug resistance was associated with significant changes in expression of 330 genes, mainly during early or intermediate stage. Functional annotation revealed a majority of genes involved in signal transduction, cell adhesion and cytoskeleton with subsequent alterations in apoptotic response, cell cycle control, drug transport, fluoropyrimidine metabolism and DNA repair. A set of 33 genes distinguished all resistant subclones from sensitive progenitor cells. In the early stage, downregulation of collagens and keratins, together with upregulation of profilin 2 and ICAM‐2, suggested cytoskeletal changes and cell adhesion remodeling. Interestingly, 6 members of the S100 calcium‐binding protein family were suppressed. Acquisition of the intermediate‐resistance phenotype included upregulation of the well‐known drug resistance gene ABCC6 (ATP‐binding cassette subfamily C member 6). The very small number of genes affected during transition to high resistance included the primary FU target thymidylate synthase. Although limited to an in vitro model, our data suggest that resistance to FU cannot be explained by known mechanisms alone and substantially involves a wide molecular repertoire. This study emphasizes the understanding of resistance as a time‐depending process: the cell is particularly challenged at the beginning of this process, while acquisition of the high‐resistance phenotype seems to be less demanding. © 2004 Wiley‐Liss, Inc.
Green tea consumption enhances survival of epithelial ovarian cancer
Authors: Zhang Min , Lee Andy H. , Binns Colin W. , Xie Xing 
Published: June 2004

AbstractOur study investigates whether tea consumption can enhance the survival of patients with epithelial ovarian cancer, a prospective cohort study was conducted in Hangzhou, China. The cohort comprised 254 patients recruited during 1999–2000 with histopathologically confirmed epithelial ovarian cancer and was followed up for a minimum of 3 years. Two hundred forty four (96.1%) of the cohort or their close relatives were traced. The variables examined included their survival time and the frequency and quantity of tea consumed post‐diagnosis. The actual number of deaths was obtained and Cox proportional hazards models were used to obtain hazard ratios and associated 95% confidence intervals (CI), adjusting for age at diagnosis, locality, BMI, parity, FIGO stage, histologic grade of differentiation, cytology of ascites, residual tumour and chemotherapeutic status. The survival experience was different between tea drinkers and non‐drinkers (p < 0.001). There were 81 (77.9%) of 104 tea‐drinkers who survived to the time of interview, compared to only 67 women (47.9%) still alive among the 140 non‐drinkers. Compared to non‐drinkers, the adjusted hazard ratios were 0.55 (95% CI = 0.34–0.90) for tea‐drinkers, 0.43 (95% CI = 0.20–0.92) for consuming at least 1 cup of green tea/day, 0.44 (95% CI = 0.22–0.90) for brewing 1 batch or more of green tea/day, 0.40 (95% CI = 0.18–0.90) for consuming more than 500 g of dried tea leaves/year, and 0.38 (95% CI = 0.15–0.97) for consuming at least 2 g of dried tea leaves/batch. The corresponding dose‐response relationships were significant (p < 0.05). We conclude that increasing the consumption of green tea post‐diagnosis may enhance epithelial ovarian cancer survival. © 2004 Wiley‐Liss, Inc.
Novel mechanism of tumorigenesis: Increased transforming growth factor‐β1 suppresses the expression of connexin 43 in BALB/cJ mice after implantation of poly‐L‐lactic acid
Authors: Ahmed Saifuddin , Tsuchiya Toshie 
Published: June 2004

AbstractPoly‐L‐lactic acid (PLLA) is a widely used promising material for surgical implants such as tissue‐engineered scaffolds. In this study, we aimed to determine the in vivo effect of PLLA plates on the cellular function of subcutaneous tissue in the two mouse strains, BALB/cJ and SJL/J, higher and lower tumorigenic strains, respectively. Gap‐junctional intercellular communication (GJIC) and the expression of connexin 43 (Cx43) protein were significantly suppressed, whereas the secretion of transforming growth factor‐β1 (TGF‐β1) level was significantly increased in PLLA‐implanted BALB/cJ mice compared with BALB/cJ controls. However, no significant difference in TGF‐β1 secretion was observed between the SJL/J‐implanted and SJL/J control mice. We found for the first time that a significant difference was observed between the two strains; thus, the PLLA increased the secretion of TGF‐β1 and suppressed the mRNA expression of Cx43 at the earlier stage after implantation into the higher‐tumorigenic strain, BALB/cJ mice. This novel mechanism might have a vital role in the inhibition of GJIC and promote the tumorigenesis in BALB/cJ mice. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 335–340, 2004