bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the stability of virtual coupling train formation based on a PID controller under the influence of time delay
Authors: Qiu Sixuan , Li Ningzhou , Wei Xiaojuan , Li Gaosong 
Published: October 2023

Abstract
As the latest research direction of train-to-train communication, virtual coupling train formation technology has attracted the attention of many scholars. This paper studies the influence of time delay on the formation of virtual coupled trains. We proposed a distributed PID controller, which means that trains can still form a stable fleet operation under the influence of communication delay and control delay. After modelling and analysis, the research uses Matlab to conduct simulation, involving two sets of experiments. Factors including speed, acceleration, position, position error, expected distance between adjacent trains and actual distance between adjacent trains are simulated. The results demonstrate that the distributed PID controller can effectively control the impact of time delay on the virtual coupling fleet.
Fms-like tyrosine kinase 3 positive acute myeloid leukemia
Authors: Isidori Alessandro , Visani Giuseppe , Ferrara Felicetto 
Published: October 2023

Purpose of review

Fms-like tyrosine kinase 3 (FLT3) mutations are common in newly diagnosed patients with acute myeloid leukemia (AML). They are associated with a high risk of relapse. The identification of FLT3 mutations has important implications for the management of AML. FLT3 inhibitors have shown improved outcomes in FLT3-positive AML when used as a single agent in the salvage setting. However, the combination of inhibitors and chemotherapy in the first-line setting is the real game changer in FLT3mutant AML. The introduction of these drugs has improved the prognosis of FLT3-mutant AML, but the development of resistance is common. There are still many unanswered questions about FLT3-mutant AML.

Recent findings
This article will analyze recent advances for FLT3-mutant AML, focusing on front-line therapy and post-transplant maintenance.

Summary
Novel drug combinations and strategies against FLT3 mutated AML are currently under investigation and will be the focus of future studies. The development of more selective and potent FLT3 inhibitors may further improve outcomes for patients with FLT3-positive AML. Monitoring minimal residual disease and overcoming resistance are key issues for the future.
Cost-Effectiveness of Cardiac Rehabilitation in Older Adults With Coronary Heart Disease
Authors: Shepard Donald S. , Zakir Shehreen , Gaalema Diann E. , Ades Philip A. 
Published: October 2023

Purpose:
While cardiac rehabilitation (CR) is recommended and effective following acute cardiac events, it remains underutilized, particularly in older adults. A study of 601 099 Medicare beneficiaries ≥65 yr hospitalized for coronary heart disease compared 5-yr mortality in users and nonusers of CR. Using instrumental variables (IV), CR improved mortality by 8.0% (P < .001). A validation analysis based on 70 040 propensity-based (PB) matched pairs gave a similar gain (8.3%, P < .0001). The present cost-effectiveness analysis builds on these mortality results.

Methods:
Using the framework of the Second Panel on Cost-Effectiveness Analysis, we calculated the incremental cost-effectiveness ratio (ICER) gained due to CR. We accessed the costs from this cohort, inflated to 2022 prices, and assessed the relationship of quality-adjusted life years (QALY) to life years from a systematic review. We estimated the ICER of CR by modeling lifetime costs and QALY from national life tables using IV and PB.

Results:
Using IV, CR added 1.344 QALY (95% CI, 0.543-2.144) and $40 472 in costs over the remaining lifetimes of participants. The ICER was $30 188 (95% CI, $18 175-$74 484)/QALY over their lifetimes. Using the PB analysis, the corresponding lifetime values were 2.018 (95% CI, 1.001-3.035) QALY, $66 590, and an ICER of $32 996 (95% CI, $21 942-$66 494)/QALY.

Conclusions:
Cardiac rehabilitation was highly cost-effective using guidelines established by the World Health Organization and the US Department of Health and Human Services. The favorable clinical effectiveness and cost-effectiveness of CR, along with low use by Medicare beneficiaries, support the need to increase CR use.
Changing society, changing research: integrating gender to better understand physical and psychological treatments use in chronic pain management
Authors: Godbout-Parent Marimée , Julien Nancy , Nguena Nguefack Hermine Lore , Pagé M. Gabrielle , Guénette Line , Blais Lucie , Beaudoin Sylvie , Bertrand Christian , Lacasse Anaïs 
Published: October 2023

Abstract
Treatment of chronic pain should be multimodal and include pharmacological, physical, and psychological treatments. However, because various barriers to physical and psychological treatments (PPTs) exist, a better understanding of biopsychosocial factors leading to their use is relevant. This study aimed to explore the association between gender identity, gender-stereotyped personality traits, and the use of PPTs in chronic pain management. The ChrOnic Pain trEatment cohort, a self-reported data infrastructure resulting from a web-based recruitment of 1935 people living with chronic pain (Quebec, Canada) was analyzed. Gender identity was operationalized as women, men, and nonbinary. Gender-stereotyped personality traits were measured using the Bem Sex-Role Inventory (feminine, masculine, androgynous, undifferentiated). A checklist of 31 types of PPTs that can be used for chronic pain management was presented to participants (yes/no). From the 1433 participants, 85.5% reported using at least one PPT. Hot–cold therapies (43.4%), exercise (41.9%), and meditation (35.2%) were the most frequently used PPTs, but most popular PPTs were not the same among women and men. Women reported a significantly higher use of PPTs in general (87.2% vs 77.2%; P < 0.001). Multivariable and interaction analyses showed that identifying as a man decreased the odds of reporting the use of PPTs (odds ratio: 0.32, 95% confidence interval: 0.11-0.92) but only among participants who scored high on both masculine and feminine personality traits (those classified as androgynous). The high prevalence of PPTs use found in our study is positive. Our results are relevant for a more personalized promotion of PPTs for chronic pain management.
GRAIL gene knockout mice protect against aging-related and noise-induced hearing loss
Authors: Chuang Kai-Fen , Wang Chih-Hung , Chen Hang-Kang , Lin Yuan-Yung , Lin Chia-Hsin , Lin Yi-Chun , Shih Cheng-Ping , Kuo Chao-Yin , Chen Ying-Chuan , Chen Hsin-Chien 
Published: October 2023

Background:
Hearing loss is a global health issue and its etiopathologies involve complex molecular pathways. The ubiquitin-proteasome system has been reported to be associated with cochlear development and hearing loss. The gene related to anergy in lymphocytes (GRAIL), as an E3 ubiquitin ligase, has not, as yet, been examined in aging-related and noise-induced hearing loss mice models.

Methods:
This study used wild-type (WT) and GRAIL knockout (KO) mice to examine cochlear hair cells and synaptic ribbons using immunofluorescence staining. The hearing in WT and KO mice was detected using auditory brainstem response. Gene expression patterns were compared using RNA-sequencing to identify potential targets during the pathogenesis of noise-induced hearing loss in WT and KO mice.

Results:
At the 12-month follow-up, GRAIL KO mice had significantly less elevation in threshold level and immunofluorescence staining showed less loss of outer hair cells and synaptic ribbons in the hook region compared with GRAIL WT mice. At days 1, 14, and 28 after noise exposure, GRAIL KO mice had significantly less elevation in threshold level than WT mice. After noise exposure, GRAIL KO mice showed less loss of outer hair cells in the cochlear hook and basal regions compared with WT mice. Moreover, immunofluorescence staining showed less loss of synaptic ribbons in the hook regions of GRAIL KO mice than of WT mice. RNA-seq analysis results showed significant differences in C-C motif chemokine ligand 19 (CCL19), C-C motif chemokine ligand 21 (CCL21), interleukin 25 (IL25), glutathione peroxidase 6 (GPX6), and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (NOX1) genes after noise exposure.

Conclusion:
The present data demonstrated that GRAIL deficiency protects against aging-related and noise-induced hearing loss. The mechanism involved needs to be further clarified from the potential association with synaptic modulation, inflammation, and oxidative stress.
Newborn cytomegalovirus screening: is this the new standard?
Authors: Gantt Soren 
Published: October 2023

Purpose of review
Congenital cytomegalovirus infection (cCMV) is a major cause of childhood hearing loss and neurodevelopmental delay. Early identification of cCMV allows for interventions that improve outcomes, particularly for cCMV-related hearing loss that develops in early childhood. Most cCMV is asymptomatic at birth and is rarely diagnosed without newborn screening. Therefore, various approaches to cCMV screening are increasingly being adopted.

Recent findings
Both universal screening (testing all newborns) and targeted screening (testing triggered by failed hearing screening) for cCMV appear valuable, feasible and cost-effective, though universal screening is predicted to have greatest potential overall benefits. CMV PCR testing of newborn oral swabs is sensitive and practical and is therefore widely used in targeted screening programs. In contrast, PCR using dried-blood spots (DBS) is less sensitive but was adopted by current universal cCMV screening initiatives because DBS are already collected from all newborns in high-income countries, which circumvents large-scale oral swab collection.

Summary
Targeted screening is widely recommended as standard of care, while universal screening is less common but is progressively considered as the optimal strategy for identification of children with cCMV. As with all screening programs, cCMV screening requires commitments to equitable and reliable testing, follow-up and services.
A massive primary congenital mesoblastic nephroma was successfully managed through open total nephrectomy: a case report
Authors: Samha Raghad , Mansour Marah , AlAwad Yara , Almaalouli Bsher , Mayhoob Reema , Al Sabbagh Aliaa , Aljundi Rama , Barakat Ali 
Published: October 2023

Background:
Congenital mesoblastic nephroma is the most common renal tumor in children under the age of 6 months, comprising 3–10% of all kidney tumors in children. It is a rare and mostly benign tumor. It divides into cellular, classic, and mixed subtypes. It is typically detected in the third trimester of pregnancy using ultrasonography and magnetic resonance imaging. The best treatment is surgically by completely removing the tumor.

Case presentation:
We reported a case of a one-day-old female who was born at 31 weeks gestation weighing 1670 g. Preterm labor was due to polyhydramnios, which was diagnosed predelivery. A large mass was detected in the left hypochondrium using computerized tomography, total nephrectomy was performed, and the histopathological examination of the specimen confirmed the diagnosis of congenital mesoblastic nephroma.

Clinical discussion and conclusion:
Early polyhydramnios could be the most significant sign of renal tumors in infants, especially congenital mesoblastic nephroma.
Identifying the Mental Health Effects of Cumulative Traumatic Exposure in HIV-Affected Youth: A Longitudinal Assessment
Authors: Morrison Corey A. , Corbeil Thomas , Kluisza Luke , Poku Ohemaa , Liotta Lucy , Attoh Okine Naa-Djama , Dolezal Curtis , Wiznia Andrew , Abrams Elaine J. , Robbins Reuben N. , Mellins Claude A. 
Published: October 2023

Introduction:
Traumatic events (TEs) in early life can precede adult psychopathology. Limited research exists on this relationship in young adults with perinatally acquired HIV-infection (PHIV) or perinatal HIV-exposure without infection (PHEU), who often experience social and health disparities. This study examined TEs experienced in childhood/adolescence and their association with psychiatric and substance use disorders in young adults with PHIV and PHEU.

Methods:
Participants in a New York City–based longitudinal cohort study were assessed for TE exposure at enrollment (mean age = 12 years) and the first 2 follow-up interviews. Past-year psychiatric and substance use disorders were evaluated via psychiatric interview (DISC-IV) at the fifth follow-up interview (mean age = 22 years). Unadjusted and adjusted logistic regression models assessed associations between cumulative childhood/adolescence TEs and young adult psychiatric and substance use outcomes. Group differences were tested for PHIV and PHEU subgroups.

Results:
Among 236 participants (60% Black, 51% Latinx), mean cumulative traumatic event count was 3.09 (SD = 1.77); 26% had a past-year psychiatric diagnosis, and 28% had a past-year substance use diagnosis. Increased TEs were associated with past-year psychiatric diagnoses in young adulthood [average marginal effects (AME) 4.21, 95% confidence interval (CI): 0.83 to 7.58]; for PHEU participants, increased TEs were associated with a past-year substance use disorder (AME 15.67, 95% CI: 8.08 to 23.25).

Conclusions:
High levels of TEs in childhood/adolescence may contribute to psychiatric and substance use disorders in young adults with PHIV or PHEU. Research exploring relationships between TE exposure and later psychiatric problems is needed to inform interventions for HIV-affected youth.
The role of interoperability and inter-side benefits on merchants' e-wallet adoption: the case of Peruvian nanostores
Authors: Libaque-Saenz Christian Fernando , Ortega Claudio , Rodriguez-Serra Michelle , Chong Mario , Lopez-Puente-de-la-Vega Salvador 
Published: October 2023

PurposeAlthough e-wallet adoption has grown in recent years, there are some countries like Peru with low penetration rates. Contrary to prior studies that focused on customers' adoption of e-wallets, this study focuses on merchants' adoption to fully understand the use of these services. Additionally, considering that e-wallets are two-sided markets with the co-existence of two distinct economic agents (customer and merchants) interacting through these platforms, this study is the first to assess the dynamics of inter-side benefits from the merchants' perspective. Finally, interoperability was also included to determine its role in countries where the interaction between different e-wallets is limited.Design/methodology/approachBased on two-sided markets and social cognitive theory, a model was proposed including merchants' perceived benefits associated with the use of e-wallets, for them and for their customers (inter-side). Additionally, technical issues such as interoperability were measured. Data were collected from nanostore owners in Lima in 2022. A structural equation modeling technique was used to determine the impact of both types of benefits and technical features on merchants' adoption of e-wallets. Finally, a polynomial regression with response surface methodology was used to assess the interaction of the benefits for both sides of the platform from the merchants' perspective.FindingsThe two-sided-market features of e-wallets were validated. From merchants' view, the use of these platforms is the result of balancing the benefits for them and for their customers, and the interaction between these two types of benefits varies according to the socio-economic level in which the nanostore operates. Additionally, interoperability was found to be important for merchants, so future policies should commit to achieve an ecosystem that facilitates the interoperability not only among e-wallets but also between e-wallets and third-party services. Finally, since service availability is also important for merchants, e-wallet providers should invest in improving their infrastructure's scalability.Originality/valuePrior studies have mainly focused on the customer side of e-wallets, with little research about the adoption of digital payment methods by the merchant side. In addition, no study has focused on the effect of one of the sides of the platform on the other side (inter-side benefits) when adopting these services. Finally, the effect of interoperability across platforms has not been addressed in detail yet. This study aims to fill these gaps by proposing a framework to understand the adoption of these services by merchants in terms of inter-side benefits and technical issues.
Visitors' experiences of UNESCO World Heritage Site: evidence from Göbeklitepe, Türkiye
Authors: Nguyen Thi Hong Hai , Ağbay Nurullah Cihan , Çakar Kadir 
Published: October 2023

PurposeThis study seeks to investigate and discuss the heritage experiences of both domestic and international visitors at Göbeklitepe UNESCO World Heritage Site in Türkiye.Design/methodology/approachA qualitative research approach was adopted in the current study. TripAdvisor's comments and reviews of both domestic (n = 519) and international (n = 186) visitors regarding their visits to Göbeklitepe were collected. The data were then subjected to content analysis by MAXQDA as qualitative data analysis software. Additionally, an abductive research approach, which consisted of three stages, was implemented for data analysis.FindingsThe three aspects of visitor experiences at Göbeklitepe, including cognitive, emotional and relational experiences were found and discussed. Additionally, commonalities and differences among domestic and international visitors in terms of the heritage experience they gained from their visit to Göbeklitepe were revealed and analyzed.Practical implicationsBased on the findings regarding the main aspects of heritage experiences at Göbeklitepe, including cognitive, emotional and relational experiences, site managers and destination marketers can create effective marketing strategies that focus on those characteristics to attract visitors to the site. Moreover, the study can guide destination marketers to develop targeted marketing campaigns that highlight the different historical and religious significance of the site for both groups of domestic and international visitors.Originality/valueFirst, the study affirms that Göbeklitepe is an important and impressive cultural heritage site due to its historical significance to both domestic and international visitors. It also strengthens the multifaceted nature of heritage experiences. Especially, the evidence of relational heritage experiences, including the connectedness to heritage and the sense of belonging to the visitor community, enriches the literature of heritage experience in this regard.
Impact of social influence on construction workers' intention-to-use exoskeletons
Authors: Gonsalves Nihar , Afolabi Adedeji , Akanmu Abiola Abosede 
Published: October 2023

PurposeLow back disorder is one of the most prevalent and costly injuries in the construction industry. Back-support exoskeletons are increasingly perceived as promising solutions. However, the intended benefits of exoskeletons may not be realized if intention-to-use the device is low. Social influence could increase intention-to-use exoskeletons. This study aims to evaluate the impact of social influence on construction workers' intention-to-use back-support exoskeletons.Design/methodology/approachA field study involving 37 construction workers was conducted, with workers who used exoskeleton for one week, and their peers and supervisors. Data were collected using questionnaires and semi-structured interviews, and analyzed using descriptive statistics and thematic analysis, respectively.FindingsThe workers felt that the exoskeleton is easy to use and the functions are well integrated. Workers' intention-to-use exoskeleton was mainly influenced by employers providing and requiring the use of the device. The attitude of the workers and the perception of peers and supervisors did not have a significant impact on workers' intention-to-use exoskeleton, whereas the subjective norm of construction workers had a positive impact on the intention-to-use exoskeletons.Research limitations/implicationsThe study involved only 37 workers, including 15 workers who used the exoskeleton, and 14 peers and 8 supervisors of the workers.Originality/valueThis study contributes to existing knowledge on the influence of social influence on intention-to-use exoskeletons. The study also highlights how exoskeleton designs and the construction workplace can influence behavioral intention-to-use exoskeletons.
Is dirt cheap? The economic costs of failing to meet soil health requirements on smallholder farms
Authors: Gourlay Sydney , Kilic Talip 
Published: October 2023

AbstractAgricultural productivity is hindered in smallholder farming systems due to several factors, including farmers’ inability to meet crop‐specific soil requirements. This article focuses on soil suitability for maize production and creates multidimensional soil suitability profiles of smallholder maize plots in Uganda while quantifying forgone production due to cultivation on less‐than‐suitable land and identifying groups of farmers that are disproportionately impacted. The analysis leverages the unique socioeconomic data from a subnational survey conducted in Eastern Uganda, inclusive of plot‐level, objective measures of maize yields and soil attributes. Stochastic frontier models of maize yields are estimated within each soil suitability class to understand differences in returns to inputs, technical efficiency, and potential yield. Farmers cultivating highly suitable soil have the potential to increase their observed yields by as much as 86%, while those at the opposite end of the suitability distribution (i.e., with marginally suitable land) operate closer to the production frontier and can only increase yields by up to 59%, given the current technology set. There is heterogeneity in potential gains across the wealth distribution, with poorer households facing more heavily constrained potential.
Measurement errors in popular night lights data may bias estimated impacts of economic sanctions: Evidence from closing the Kaesong Industrial Zone
Authors: Kim Bonggeun , Gibson John , Boe‐Gibson Geua 
Published: October 2023

AbstractSatellite‐detected night lights data are widely used to evaluate economic impacts of sanctions. Such data should be free from political manipulation. However, measurement errors in these data, from blurring and bottom‐coding, are rarely considered. To study such errors, we use a difference‐in‐differences analysis of impacts of closing the Kaesong Industrial Zone in North Korea—a sanction South Korea imposed in 2016. Luminosity in the affected region declined by a precisely estimated 50 percent. When using the popular Defense Meteorological Satellite Program (DMSP) night lights data the apparent impacts are imprecisely estimated and far smaller. Measurement errors in DMSP data may distort evaluations of sanctions.