bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting cancer-associated adipocyte-derived CXCL8 inhibits triple-negative breast cancer progression and enhances the efficacy of anti-PD-1 immunotherapy
Authors: Huang Renhong , Wang Zheng , Hong Jin , Wu Jiayi , Huang Ou , He Jianrong , Chen Weiguo , Li Yafen , Chen Xiaosong , Shen Kunwei 
Published: October 2023

AbstractCancer-associated adipocytes (CAAs), one of the primary stromal components, exhibit intimate crosstalk and release multiple cell factors mediating local and systemic biological effects. However, the role of CAAs in the regulation of systemic immune responses and their potential value in the clinical treatment of triple-negative breast cancer (TNBC) are not well described. Transcriptome sequencing was performed on CAA and normal adipocyte (NA) tissues isolated from surgically resected samples from TNBC patients and healthy controls. Cytokines, including C-X-C motif chemokine ligand 8 (CXCL8, also known as IL-8), secreted from NAs and CAAs were compared by transcriptome sequencing and enzyme-linked immunosorbent assay (ELISA). Proliferation, migration and invasion assays were employed to analyze the role of CAAs and CAA-derived CXCL8 (macrophage inflammatory protein-2 (MIP2) as a functional surrogate in mice). TNBC syngraft models were established to evaluate the curative effect of targeting CXCL8 in combination with anti-PD-1 therapies. Real-time quantitative polymerase chain reaction (RT-qPCR), western blotting (WB), polymerase chain reaction (PCR) array, flow cytometry, immunohistochemistry (IHC), and immunofluorescence (IF) were applied to analyze immune cell infiltration and epithelial–mesenchymal transition (EMT) markers. Specifically, we demonstrated that CAAs and CAA-derived CXCL8 played important roles in tumor growth, EMT, metastasis and tumor immunity suppression. CAA-derived CXCL8 remodeled the tumor immune microenvironment not only by suppressing CD4+ T and CD8+ T immune cell infiltration but also by upregulating CD274 expression in TNBC. The combination of targeting the CXCL8 pathway and blocking the PD-1 pathway synergistically increased the tumor immune response and inhibited tumor progression. Thus, our results highlight the molecular mechanisms and translational significance of CAAs in tumor progression and immune ecosystem regulatory effects and provide a better understanding of the potential clinical benefit of targeting CAA-derived CXCL8 in antitumor immunity and as a new therapeutic moiety in TNBC.
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
Authors: Bayona-Feliu Aleix , Herrera-Moyano Emilia , Badra-Fajardo Nibal , Galván-Femenía Iván , Soler-Oliva María Eugenia , Aguilera Andrés 
Published: October 2023

AbstractGenome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication conflicts (TRCs). Here we show that TRCs trigger a DNA Damage Response (DDR) involving the chromatin network to prevent genome instability. Depletion of the key chromatin factors INO80, SMARCA5 and MTA2 results in TRCs, fork stalling and R-loop-mediated DNA damage which mostly accumulates at S/G2, while histone H3 Ser10 phosphorylation, a mark of chromatin compaction, is enriched at TRCs. Strikingly, TRC regions show increased mutagenesis in cancer cells with signatures of homologous recombination deficiency, transcription-coupled nucleotide excision repair (TC-NER) and of the AID/APOBEC cytidine deaminases, being predominant at head-on collisions. Thus, our results support that the chromatin network prevents R-loops and TRCs from genomic instability and mutagenic signatures frequently associated with cancer.
Copula-based risk aggregation with trapped ion quantum computers
Authors: Zhu Daiwei , Shen Weiwei , Giani Annarita , Ray-Majumder Saikat , Neculaes Bogdan , Johri Sonika 
Published: October 2023

AbstractCopulas are mathematical tools for modeling joint probability distributions. In the past 60 years they have become an essential analysis tool on classical computers in various fields. The recent finding that copulas can be expressed as maximally entangled quantum states has revealed a promising approach to practical quantum advantages: performing tasks faster, requiring less memory, or, as we show, yielding better predictions. Studying the scalability of this quantum approach as both the precision and the number of modeled variables increase is crucial for its adoption in real-world applications. In this paper, we successfully apply a Quantum Circuit Born Machine (QCBM) based approach to modeling 3- and 4-variable copulas on trapped ion quantum computers. We study the training of QCBMs with different levels of precision and circuit design on a simulator and a state-of-the-art trapped ion quantum computer. We observe decreased training efficacy due to the increased complexity in parameter optimization as the models scale up. To address this challenge, we introduce an annealing-inspired strategy that dramatically improves the training results. In our end-to-end tests, various configurations of the quantum models make a comparable or better prediction in risk aggregation tasks than the standard classical models.
An investigation into a semi-porous channel's forced convection of nano fluid in the presence of a magnetic field as a result of heat radiation
Authors: Jalili Bahram , Shateri Amirali , Akgül Ali , Bariq Abdul , Asadi Zohreh , Jalili Payam , Ganji Davood Domiri 
Published: October 2023

AbstractThis study investigates the impact of heat radiation on magnetically-induced forced convection of nanofluid in a semi-porous channel. The research employs Akbari-Ganji's and Homotopy perturbation methods to analyze the effects of multiple parameters, including Hartmann number, Reynolds number, Eckert number, radiation parameter, and suction parameter, on the flow and heat transfer characteristics. The results demonstrate that increasing Reynolds number, suction, and radiation parameters increases temperature gradient, providing valuable insights into improving heat transfer in semi-porous channels. The study validates the proposed methods by comparing the results with those obtained from other established methods in the literature. The main focus of this work is to understand the behavior of nanofluids in semi-porous channels under the influence of magnetic fields and heat radiation, which is essential for various industrial and engineering applications. The future direction of this research includes exploring the effects of different nanoparticle shapes and materials on heat transfer performance and investigating the influence of other parameters, such as buoyancy forces and variable properties, on the flow and heat transfer characteristics. The findings of this study are expected to contribute to the development of more efficient thermal management systems in the future.
Analysis of thyroid function and related factors in narcolepsy patients
Authors: Wang Hongli , Jia Mingrui 
Published: October 2023

AbstractThe loss of hypocretin is thought to be the main pathophysiological mechanism of narcolepsy. There is strong evidence that hypocretin is related to the regulation of endocrine functions and depression. To explore thyroid hormone levels in narcolepsy patients was our aim. In addition, further is to analyze the relationship between thyroid hormone levels and sleep quality, anxiety, and depression in narcolepsy patients. There are 40 patients with narcolepsy and 40 healthy controls (HCs) were conducted. Blood samples were explored for thyroid function. Correlation analysis between thyroid hormones and clinical characteristics of narcolepsy was performed using Pearson or Spearman. Narcolepsy patients had significantly lower free thyroxine (FT4) levels in comparison to controls (p < 0.001). No subject was diagnosed with primary hypothyroidism. There were 4 (10%) subjects with subclinical hypothyroidism. The serum FT4 levels were positively correlated with HAMA14 score (r = − 0.343, p = 0.030) by Pearson correlation analysis. The serum TSH levels and HAMD24 score (r = − 0.807 p ˂0.001), and ESS score (r = − 0.317, p = 0.046) both showed a negative correction. Hypocretin deficiency may be associated with the regulation of thyroid hormones in narcolepsy patients. The serum thyroid hormones may affect the severity and neuropsychological functions of narcolepsy patients.
Clinico-radiologic subtypes and therapeutic observation of acute Marchiafava-Bignami disease
Authors: Zhang Yan-li , Ran Chao , Xu Chao , Li Wei 
Published: October 2023

AbstractWe aimed to investigate the clinico-radiologic features of acute Marchiafava-Bignami disease (MBD) and its evolutionary process after effective treatment through subgroup comparison. The clinical and MRI data of 23 patients with acute MBD were retrospectively analyzed and divided into type A (12 cases, with entire callosal involvement) and type B (11 cases, with focal callosal involvement). The clinical assessments and MRI findings (before and after treatment) were compared between the two subtypes. Compared with type B, type A had lower MoCA (Montreal Cognitive Assessment) scores at admission (16.50 ± 1.73 vs 18.27 ± 1.68, P = 0.021) and were more common with extracallosal involvement (66.67% vs 18.18%, P = 0.036) and longer illness duration (18.3 ± 2.1 days vs 15.6 ± 2.4 days, P = 0.012). During the treatment, the residual lesion in the splenium was more common in type A (58.33% vs 9.09%, P = 0.027). After treatment, the MoCa scores of both subtypes gradually increased (P < 0.001), and the callosal and extracallasal lesions disappeared completely. Clinico-radiologic typing of acute MBD is related to the severity of early symptoms, but not to the prognosis. Complete clinico-radiologic recovery is possible for both subtypes with combined treatment. The clinico-radiologic reversibility is helpful for accurate diagnosis and therapeutic evaluation.
Periodic fluctuations in reading times reflect multi-word-chunking
Authors: Lo Chia-Wen , Anderson Mark , Henke Lena , Meyer Lars 
Published: October 2023

AbstractMemory is fleeting. To avoid information loss, humans need to recode verbal stimuli into chunks of limited duration, each containing multiple words. Chunk duration may also be limited neurally by the wavelength of periodic brain activity, so-called neural oscillations. While both cognitive and neural constraints predict some degree of behavioral regularity in processing, this remains to be shown. Our analysis of self-paced reading data from 181 participants reveals periodic patterns at a frequency of $$\sim$$
∼
2 Hz. We defined multi-word chunks by using a computational formalization based on dependency annotations and part-of-speech tags. Potential chunk outputs were first generated from the computational formalization and the final chunk outputs were selected based on normalized pointwise mutual information. We show that behavioral periodicity is time-aligned to multi-word chunks, suggesting that the multi-word chunks generated from local dependency clusters may minimize memory demands. This is the first evidence that sentence processing behavior is periodic, consistent with a role of both memory constraints and endogenous electrophysiological rhythms in the formation of chunks during language comprehension.
Retrospective judgments of confidence in a complex span task
Authors: Lau Giovanny , Moulin Chris J. A. , Portrat Sophie 
Published: October 2023

AbstractAlthough the study of metamemory monitoring originated in predictions for simple span tasks, the study of metacognition for working memory (WM) has been somewhat neglected in comparison with long-term memory. We aimed to fill this gap by exploring the ability to self-assess WM operations. Thirty-four participants performed 16 series of complex span tasks and rated their confidence in a verbal recall paradigm. We manipulated the cognitive load based on the TBRS model in order to analyze the role of attentional resources on both WM and metacognitive evaluations. As expected, we found that recall is affected by cognitive load and we found standard serial position effects. Interestingly, metacognitive evaluations followed the same pattern, and measures of metacognitive sensitivity suggest that participants are able to make item-by-item retrospective judgments reflective of their performance. We discuss how these results contribute to our understanding of metacognitive access to newly-formed WM contents.
Imaging low-energy positron beams in real-time with unprecedented resolution
Authors: Berghold Michael , Burwitz Vassily Vadimovitch , Mathes Lucian , Hugenschmidt Christoph , Guatieri Francesco 
Published: October 2023

AbstractParticle beams focused to micrometer-sized spots play a crucial role in forefront research using low-energy positrons. Their expedient and wide application, however, requires highly-resolved, fast beam diagnostics. We have developed two different methods to modify a commercial imaging sensor to make it sensitive to low-energy positrons. The first method consists in removing the micro-lens array and Bayer filter from the sensor surface and depositing a phosphor layer in their place. This procedure results in a detector capable of imaging positron beams with energies down to a few tens of eV, or an intensity as low as $${35}\,{\hbox {e}^+/\hbox {s/mm}^{2}}$$

35

e
+

/

s/mm
2

when the beam energy exceeds 10 $${\hbox {keV}}$$
keV
. The second approach omits the phosphor deposition; with the resulting device we succeeded in detecting single positrons with energies upwards of $${6}\,{\hbox {keV}}$$

6

keV

and efficiency up to 93%. The achieved spatial resolution of 0.97 $$\upmu \hbox {m}$$

μ
m

is unprecedented for real-time positron detectors.
Exploring new subgroups for irritable bowel syndrome using a machine learning algorithm
Authors: Mousavi Elahe , Hassanzadeh Keshteli Ammar , Sehhati Mohammadreza , Vaez Ahmad , Adibi Peyman 
Published: October 2023

AbstractIrritable bowel syndrome (IBS) is a complicated gut-brain axis disorder that has typically been classified into subgroups based on the major abnormal stool consistency and frequency. The presence of components other than lower gastrointestinal (GI) symptoms, such as psychological burden, has also been observed in IBS manifestations. The purpose of this research is to redefine IBS subgroups based on upper GI symptoms and psychological factors in addition to lower GI symptoms using an unsupervised machine learning algorithm. The clustering of 988 individuals who met the Rome III criteria for diagnosis of IBS was performed using a mixed-type data clustering algorithm. Nine sub-groups emerged from the proposed clustering: (I) High diarrhea, pain, and psychological burden, (II) High upper GI, moderate lower GI, and psychological burden, (III) High psychological burden and moderate overall GI, (IV) High constipation, moderate upper GI, and high psychological burden, (V) moderate constipation and low psychological burden, (VI) High diarrhea and moderate psychological burden, (VII) moderate diarrhea and low psychological burden, (VIII) Low overall GI, and psychological burden, (IX) Moderate lower GI, and low psychological burden. The proposed procedure led to the discovery of new homogeneous clusters in addition to certain well-known Rome sub-types for IBS.
Relation of serum uric acid levels to readmission and mortality in patients with heart failure
Authors: Li Zengpan , Yuan Jie , Hu Encong , Wei Diyang 
Published: October 2023

AbstractData on the association between uric acid (UA) levels and clinical outcomes, such as readmission and mortality, in patients with heart failure are scarce. This study explores whether UA exhibits an independent association with the composite endpoint (clinical outcome during 6 months after discharge, including mortality and 6-month readmission) in patients with chronic heart failure while controlling for other covariates. This study was an observational retrospective study. A cohort of 1943 consecutive patients diagnosed with chronic heart failure, who were admitted between December 2016 and June 2019, was included in the study. Data were sourced from PhysioNet. The independent variable analyzed was the UA level, and the dependent variable was a composite endpoint comprising mortality and 6-month readmission. The study had 1943 participants, of which 91.04% were aged more than 60 years and 58.05% were female. The fully-adjusted model yielded a positive correlation between UA levels (per 10 µmol/L) and the composite endpoint as well as readmission, following adjustment for confounding variables (HR = 1.01, 95% CI 1.00–1.01). Notably, a non-linear relationship was observed between UA levels and the composite endpoint, particularly readmission, with a J-shaped correlation observed between UA levels and both the composite endpoint and readmission. Overall, we found that the serum UA levels at admission were independently and positively associated with the risk of the composite endpoint (clinical outcomes during 6 months after discharge), especially readmission after adjusting other covariates. A J-shaped relationship was observed between UA levels and the composite endpoint and readmission.
Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers–Danlos syndrome
Authors: Kamada Hiroki , Emura Kousuke , Yamamoto Rikuto , Kawahara Koichi , Uto Sadahito , Minami Toshiaki , Ito Seiji , Matsumoto Ken-ichi , Okuda-Ashitaka Emiko 
Published: October 2023

AbstractDeficiency of an extracellular matrix glycoprotein tenascin-X (TNX) leads to a human heritable disorder Ehlers–Danlos syndrome, and TNX-deficient patients complain of chronic joint pain, myalgia, paresthesia, and axonal polyneuropathy. We previously reported that TNX-deficient (Tnxb−/−) mice exhibit mechanical allodynia and hypersensitivity to myelinated A-fibers. Here, we investigated the pain response of Tnxb−/− mice using pharmacological silencing of A-fibers with co-injection of N-(2,6-Dimethylphenylcarbamoylmethyl) triethylammonium bromide (QX-314), a membrane-impermeable lidocaine analog, plus flagellin, a toll-like receptor 5 (TLR5) ligand. Intraplantar co-injection of QX-314 and flagellin significantly increased the paw withdrawal threshold to transcutaneous sine wave stimuli at frequencies of 250 Hz (Aδ fiber responses) and 2000 Hz (Aβ fiber responses), but not 5 Hz (C fiber responses) in wild-type mice. The QX-314 plus flagellin-induced silencing of Aδ- and Aβ-fibers was also observed in Tnxb−/− mice. Co-injection of QX-314 and flagellin significantly inhibited the mechanical allodynia and neuronal activation of the spinal dorsal horn in Tnxb−/− mice. Interestingly, QX-314 alone inhibited the mechanical allodynia in Tnxb−/− mice, and it increased the paw withdrawal threshold to stimuli at frequencies of 250 Hz and 2000 Hz in Tnxb−/− mice, but not in wild-type mice. The inhibition of mechanical allodynia induced by QX-314 alone was blocked by intraplantar injection of a TLR5 antagonist TH1020 in Tnxb−/− mice. These results suggest that mechanical allodynia due to TNX deficiency is caused by the hypersensitivity of Aδ- and Aβ-fibers, and it is induced by constitutive activation of TLR5.
Usage of fractional order $${\textrm{PI}}^\lambda {\textrm{D}}^\mu$$ controller as AQM algorithm
Authors: Marszałek Karol , Domański Adam , Milik Adam 
Published: October 2023

AbstractThe article describes the Usage of fractional order $${\textrm{PI}}^\lambda {\textrm{D}}^\mu$$

PI

λ

D

μ

controller as AQM algorithm. The alternative, integer-based calculation process for $${\textrm{PI}}^\lambda {\textrm{D}}^\mu$$

PI

λ

D

μ

controller is proposed and tested in numerical analysis, simulation environment, and Linux-based testbed environment with real-life devices. The FPGA design for the calculation process is presented. Experimental evaluation and setup process for AQM in the network is presented.
Artificial intelligence-based framework for precise prediction of asphaltene particle aggregation kinetics in petroleum recovery
Authors: Sharifzadegan Ali , Behnamnia Mohammad , Dehghan Monfared Abolfazl 
Published: October 2023

AbstractThe precipitation and deposition of asphaltene on solid surfaces present a significant challenge throughout all stages of petroleum recovery, from hydrocarbon reservoirs in porous media to wellbore and transfer pipelines. A comprehensive understanding of asphaltene aggregation phenomena is crucial for controlling deposition issues. In addition to experimental studies, accurate prediction of asphaltene aggregation kinetics, which has received less attention in previous research, is essential. This study proposes an artificial intelligence-based framework for precisely predicting asphaltene particle aggregation kinetics. Different techniques were utilized to predict the asphaltene aggregate diameter as a function of pressure, temperature, oil specific gravity, and oil asphaltene content. These methods included the adaptive neuro-fuzzy interference system (ANFIS), radial basis function (RBF) neural network optimized with the Grey Wolf Optimizer (GWO) algorithm, extreme learning machine (ELM), and multi-layer perceptron (MLP) coupled with Bayesian Regularization (BR), Levenberg–Marquardt (LM), and Scaled Conjugate Gradient (SCG) algorithms. The models were constructed using a series of published data. The results indicate the excellent correlation between predicted and experimental values using various models. However, the GWO-RBF modeling strategy demonstrated the highest accuracy among the developed models, with a determination coefficient, average absolute relative deviation percent, and root mean square error (RMSE) of 0.9993, 1.1326%, and 0.0537, respectively, for the total data.
Cohabitation with aggressive hosts: description of a new microhisterid species in nests of a ponerine ant with ecological notes
Authors: Pérez-Lachaud Gabriela , Degallier Nicolas , Gomy Yves , Elías-Gutiérrez Manuel , Rocha Franklin H. , Lachaud Jean-Paul 
Published: October 2023

AbstractA new clown beetle species, Bacanius neoponerae, is described from Mexican nests of the arboreal ponerine ant Neoponera villosa found in the tank bromeliad Aechmea bracteata. Adult beetles were found in brood chambers or inner refuse piles, but also outside the ant nests, in decaying organic matter between the bromeliad leaves. No direct interactions between ants and microhisterid beetles could be observed. Several lines of evidence suggest a close relationship either with the ants, specific microhabitats within the ant nests or the bromeliads. Sample site elevation, colony size, monthly rainfall and collecting site were the main variables predicting the association. Almost half of the N. villosa colonies were associated with the microhisterids, and larger colonies favored their presence, especially during the driest months of the year. Two specimens were found in a nest of another ant species, Camponotus atriceps, also inhabiting A. bracteata. The new species is the seventh of the genus Bacanius reported from Mexico. This is the second time a species of this genus is associated with ants, and the fourth record of a histerid beetle cohabiting with ponerine ants. The small size of these beetles and their very protective body structure may facilitate their cohabitation with such aggressive hosts.