bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation
Authors: Kim Eugene E. , Shekhar Akshay , Ramachandran Jayalakshmi , Khodadadi-Jamayran Alireza , Liu Fang-Yu , Zhang Jie , Fishman Glenn I. 
Published: October 2023

ABSTRACT
Reciprocal interactions between non-myocytes and cardiomyocytes regulate cardiac growth and differentiation. Here, we report that the transcription factor Ebf1 is highly expressed in non-myocytes and potently regulates heart development. Ebf1-deficient hearts display myocardial hypercellularity and reduced cardiomyocyte size, ventricular conduction system hypoplasia, and conduction system disease. Growth abnormalities in Ebf1 knockout hearts are observed as early as embryonic day 13.5. Transcriptional profiling of Ebf1-deficient embryonic cardiac non-myocytes demonstrates dysregulation of Polycomb repressive complex 2 targets, and ATAC-Seq reveals altered chromatin accessibility near many of these same genes. Gene set enrichment analysis of differentially expressed genes in cardiomyocytes isolated from E13.5 hearts of wild-type and mutant mice reveals significant enrichment of MYC targets and, consistent with this finding, we observe increased abundance of MYC in mutant hearts. EBF1-deficient non-myocytes, but not wild-type non-myocytes, are sufficient to induce excessive accumulation of MYC in co-cultured wild-type cardiomyocytes. Finally, we demonstrate that BMP signaling induces Ebf1 expression in embryonic heart cultures and controls a gene program enriched in EBF1 targets. These data reveal a previously unreported non-cell-autonomous pathway controlling cardiac growth and differentiation.
The effects of group psychodrama on the ruminative thinking style, dysfunctional attitudes, anxiety and depressive symptoms: a quasi-experimental study
Authors: Yeşil Örnek Bahar , Kırlangıç Şimşek Bircan 
Published: October 2023

Aim of the studyThe aim of the study where quasi-experimental method was used with the control group through pre-post test design was to investigate the effect of psychodrama on symptoms of ruminative thinking style and dysfunctional attitudes as well as the anxiety and depression.Subject or material and methodsThis study included 16 adults including 8 individuals in the psychodrama and 8 individuals in the control group. A group therapy was conducted with the psychodrama group for 12 sessions during 6 weeks; the control group was observed without any intervention.ResultsThe psychodrama group scale scores were significantly lower in end tests in the intragroup analysis; there was not any difference in the control group.DiscussionWith psychodramatic techniques, increasing and maintaining attention; reduce or replace ruminations by concretizing and be able to reprocess death, mourning, uncertain loss and trauma through staging; have the opportunity to experience functional attitudes in the sur-plus reality scene and develop functional beliefs and attitudes may have contributed to our results.ConclusionsOur results reveal that psychodrama techniques are useful in ruminative thinking and dysfunctional attitudes which play a role in the cognitive aspects of anxiety and depression.
Risk factors for blood transfusion and postoperative anaemia following total knee arthroplasty
Authors: Kolin David A. , Sculco Peter K. , Gonzalez Della Valle Alejandro , Rodriguez Jose A. , Ast Michael P. , Chalmers Brian P. 
Published: October 2023

AimsBlood transfusion and postoperative anaemia are complications of total knee arthroplasty (TKA) that are associated with substantial healthcare costs, morbidity, and mortality. There are few data from large datasets on the risk factors for these complications.MethodsWe retrospectively reviewed the records of TKA patients from a single tertiary care institution from February 2016 to December 2020. There were a total of 14,901 patients in this cohort with a mean age of 67.9 years (SD 9.2), and 5,575 patients (37.4%) were male. Outcomes included perioperative blood transfusion and postoperative anaemia, defined a priori as haemoglobin level < 10 g/dl measured on the first day postoperatively. In order to establish a preoperative haemoglobin cutoff, we investigated a preoperative haemoglobin level that would limit transfusion likelihood to ≤ 1% (13 g/dl) and postoperative anaemia likelihood to 4.1%. Risk factors were assessed through multivariable Poisson regression modelling with robust error variance.ResultsIn multivariable analyses, each gram of tranexamic acid reduced transfusion likelihood by 39% (adjusted risk ratio (ARR) 0.61 (95% confidence interval (CI) 0.47 to 0.78)). Risk factors associated with an increased risk of transfusion included operating time (ARR 2.07 (95% CI 1.54 to 2.77)) and drain use (ARR 1.73 (95% CI 1.34 to 2.24)).ConclusionIn this study, we found that increased tranexamic acid dosing, decreased operating time, and decreased drain use may reduce transfusions following TKA. We also established a single preoperative haemoglobin cutoff of 13 g/dl that could help minimize transfusions and reduce postoperative complete blood counts.Cite this article: Bone Joint J 2023;105-B(10):1086–1093.
The potential of beneficial microbes to suppress the development of bacterial leaf blight in rice plants caused by Xanthomonas oryzae pv. oryzae
Authors: RAHMA HALIATUR , MARTINIUS MARTINIUS , KHAIRUL UJANG , RAHMI FADHILA 
Published: October 2023

Abstract. Rahma H, Martinius, Khairul U, Rahmi F. 2023. The potential of beneficial microbes to suppress the development of bacterial leaf blight in rice plants caused by Xanthomonas oryzae pv. oryzae. Biodiversitas 24: 4209-4217. Xanthomonas oryzae pv. oryzae (Xoo) is caused bacterial leaf blight in rice plants. One technique for controlling the bacterial leaf blight that currently being developed is using beneficial microbes. The purpose of this study was to isolate and identified beneficial microbes that can suppress bacterial leaf blight development in rice plants. In the present study fifteen isolates of beneficial microbes were investigated for their potential as an antagonist against Xoo, the causal agent of bacterial leaf blight of rice plants. Four isolates, namely Act-SK2, Act-Mn2, Act-Hr21, and Act-Pha4, showed the ability to reduce the area under progress curve (AUDPC) values by 51.33, 51.00, 84.00, and 82.33, respectively. The effectiveness of AUDPC suppression ranged between 80%-88%. Two out of four isolates showed potential in reducing the severity of BLB disease by 3.65% (Act-Sk2) and 3.88% (Act-Mn2) as compared to control. The effectiveness of both isolates in reducing disease severity was 86.34% (Act-Sk2) and 85.48% (Act-Mn2). Furthermore, identification based on 16S rRNA gene sequence analysis showed that three isolates, namely Act-Sk2, Act-Hr21, and Act-Pha4, belong to Actinobacteria. Each isolate showed 99.68% similarities with Streptomyces sp. strain KS02 (Acc. No. AB373961, 99.84% with Streptomyces sp. strains Al-Dhabi-119 (Acc. No.MK675528), and 99.64% with Streptomyces griseus strain K 2 (Acc. No. MK811436). Isolate Act-Mn2 showed 100% similarity with Penicillium janthinellum strain CMV006C1 (Acc. No. MK450697). The results of this study indicate that the four microorganisms tested have potential to be developed as biological agents.
A Predictive Model to Identify the Effects of Transcutaneous Sacral Nerve Stimulation With Pelvic Floor Exercises in Fecal Incontinence After Surgery for Anorectal Malformation
Authors: Shen Zhe-Ying , Zhang Yao , Tao Chun-Hong , Wang Da-Jia , Zhang Zhi-Bo , Zhang Shu-Cheng 
Published: October 2023

INTRODUCTION:Although the combination of transcutaneous sacral nerve stimulation (tSNS) and pelvic floor exercises (PFEs) has shown significant effectiveness in treating fecal incontinence (FI) after surgery for congenital anorectal malformation (CARM), not all patients achieve satisfactory continence. Therefore, identifying which individuals will benefit from this method is crucial.METHODS:A prospective cohort study enrolled 92 children with FI. All patients underwent tSNS with PFE treatment, and an improved outcome was defined as a Wexner score ≤4. A predictive model to identify the effects of tSNS with PFEs in FI was developed based on the analysis of magnetic resonance imaging and high-resolution anorectal manometry with area under the receiver-operating characteristic curve to evaluate the predictive value of external anal sphincter (EAS) thickness index and anal squeezing pressure (ASP).RESULTS:tSNS with PFEs improved outcomes in 72 patients and led to poor outcomes in 20 (4 had their rectums deviate from the puborectalis muscle center or puborectal muscle ruptures while 16 lacked EAS with a lower ASP). The areas under the receiver-operating characteristic curve for EAS thickness index and ASP in predicting the effects of tSNS with PFEs were 0.915 (95% confidence interval 0.846–0.983,P= 0.000) and 0.886 (95% confidence interval 0.819–0.952,P= 0.000), respectively. By applying cutoff values of 0.076 for EAS thickness index and 21.95 mm Hg for ASP, tSNS with PFEs was found to be ineffective.DISCUSSION:tSNS with PFEs is effective for most patients with FI after CARM surgery, except when the rectum deviates from the puborectal muscle center, puborectal muscle rupture occurs, or EAS is absent with a low ASP.
The Impact of Patients' Primary Language on Inpatient Gastrointestinal Bleeding Outcomes
Authors: Youssef Michael , Rubens Muni , Sedarous Mary , Babajide Oyedotun , Adekunle Deborah , Mahmud Muftah , Roque Maria Vazquez , Okafor Philip N. 
Published: October 2023

BACKGROUND:
The impact of English proficiency on gastrointestinal bleeding (GIB) outcomes remains unclear. In this analysis, we compare inpatient GIB outcomes between patients with English as their primary language (EPL) and those with a primary language other than English (PLOE).

METHODS:
Using the 2019 State Inpatient Databases for New Jersey, Maryland, and Michigan, we created an analysis cohort of GIB hospitalizations using International Classification of Diseases, 10th Revision codes. Patients were stratified by primary language (EPL vs PLOE) and type of bleeding (variceal upper GI bleeding [VUGIB], nonvariceal upper GI bleeding [NVUGIB], and lower GI bleeding (LGIB)]. Regression analyses were used to compare mortality, 30-day readmissions, and length of stay. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were reported. P < 0.05 was considered statistically significant.

RESULTS:
In the cohort, 5.5%–10% of the patients spoke a primary language other than English. Endoscopy utilization was lower among patients with PLOE vs EPL for NVUGIB (17.2% vs 21.2%, P < 0.001) and LGIB (26.3% vs 29.2%, P = 0.027). Patients with PLOE had higher odds of dying of VUGIB (aOR 1.45, 95% CI 1.16–2.48) and LGIB (aOR 1.71, 95% CI 1.22–2.12). Patients with PLOE were also more likely to be readmitted after NVUGIB (aOR 1.75, 95% CI 1.64–1.81). However, after controlling for the percentage of patients with PLOE discharged from each hospital, the disparities in mortality and readmissions were no longer detected.

DISCUSSION:
Disparities exist in GIB outcomes among patients with PLOE, but these gaps narrow at hospitals with higher percentages of patients with PLOE. Cultural and linguistic competence may improve outcomes in this vulnerable group.
Minimizing movements for anisotropic and inhomogeneous mean curvature flows
Authors: Chambolle Antonin , De Gennaro Daniele , Morini Massimiliano 
Published: October 2023

Abstract
In this paper we address anisotropic and inhomogeneous mean curvature flows with forcing and mobility, and show that the minimizing movements scheme converges to level set/viscosity solutions and to distributional solutions à la Luckhaus–Sturzenhecker to such flows, the latter result holding in low dimension and conditionally to the convergence of the energies. By doing so we generalize recent works concerning the evolution by mean curvature by removing the hypothesis of translation invariance, which in the classical theory allows one to simplify many arguments.
Self-Reported Mental Health and the Demand for Mental Health Care After a Labor Market Shock: Evidence from the Spanish Great Recession
Authors: Polo-Muro Eduardo Ignacio 
Published: October 2023

Abstract
This research examines the mental health inequalities between employed and unemployed individuals among the fluctuations over the business cycle. To analyze whether a recession affects self-evaluated mental health and consequently increases the demand for mental health care, I exploit the sudden increase of the unemployment rate in Spain during the period 2007–2009. First, I analyze the impairment of self-evaluated mental health as a consequence of the Great Recession and if it prevails during the economic recovery. In addition, I estimate if the effect on self-reported mental health is reflected in demand for mental health care. The results from an event study design show that the economic downturn increases the differences between employed and unemployed individuals in self-evaluated mental health. However, and despite the continuous improvement in unemployment, the mental health gap remained unchanged between 2014 and 2017, which could imply the persistence of some lasting impacts of the Great Recession on mental health. Nonetheless, I find a reduction in the differences of using drugs related to mental health during the period 2011–2012, when I estimate the largest inequalities in self-evaluated mental health.
The quasi-Zariski topology on the graded quasi-primary spectrum of a graded module over a graded commutative ring
Authors: Jaradat Malik , Al-Zoubi Khaldoun 
Published: October 2023

Abstract
Let G be a group. Let R be a G-graded commutative
ring and let M be a graded R-module. A proper graded submodule Q of M is
called a graded quasi-primary submodule if whenever

r
∈

h
⁢

(
R
)

{r\in h(R)}

and

m
∈

h
⁢

(
M
)

{m\in h(M)}

with

r
⁢
m

∈
Q

{rm\in Q}

, then either

r
∈
Gr

(

(
Q

:
R

M
)

)

{r\in\operatorname{Gr}((Q:_{R}M))}

or

m
∈

Gr
M

⁡

(
Q
)

{m\in\operatorname{Gr}_{M}(Q)}

.
The graded quasi-primary spectrum

qp
.
Spec

g

(
M
)

{\mathop{\rm qp.Spec}\nolimits_{g}(M)}

is defined to be the set
of all graded quasi-primary submodules of M. In this paper, we introduce
and study a topology on

qp
.
Spec

g

(
M
)

{\mathop{\rm qp.Spec}\nolimits_{g}(M)}

, called the quasi-Zariski topology,
and investigate the properties of this topology and some conditions under which

(

qp
.
Spec

g

(
M
)

,
q

.

τ
g

)

{(\mathop{\rm qp.Spec}\nolimits_{g}(M),q.\tau^{g})}

is a Noetherian, spectral space.
The good or the bad: an overview of autoantibodies in traumatic spinal cord injury
Authors: Guntermann Annika , Marcus Katrin , May Caroline 
Published: October 2023

Abstract
Infections remain the most common cause of death after traumatic spinal cord injury, likely due to a developing immune deficiency syndrome. This, together with a somewhat contradictory development of autoimmunity in many patients, are two major components of the maladaptive systemic immune response. Although the local non-resolving inflammation in the lesioned spinal cord may lead to an antibody formation against autoantigens of the injured spinal cord tissue, there are also natural (pre-existing) autoantibodies independent of the injury. The way in which these autoantibodies with different origins affect the neuronal and functional outcome of spinal cord-injured patients is still controversial.
A note on the degree of ill-posedness for mixed differentiation on the d-dimensional unit cube
Authors: Hofmann Bernd , Fischer Hans-Jürgen 
Published: October 2023

Abstract
Numerical differentiation of a function over the unit interval of the real axis, which is contaminated with noise, by inverting the simple integration operator J mapping in

L
2

{L^{2}}

is discussed extensively in the literature. The complete singular system of the compact operator J is explicitly
given with singular values

σ
n

⁢

(
J
)

{\sigma_{n}(J)}

asymptotically proportional to

1
n

{\frac{1}{n}}

. This indicates a degree one of ill-posedness for the associated inverse problem of differentiation. We recall the concept of the degree of ill-posedness for linear operator equations with compact forward operators in Hilbert spaces. In contrast to the one-dimensional case, there is little specific material available about the inverse problem of mixed differentiation, where the d-dimensional analog

J
d

{J_{d}}

to J, defined over unit d-cube, is to be inverted.
In this note, we show for that problem that the degree of ill-posedness stays at one for all dimensions

d
∈
ℕ

{d\in{\mathbb{N}}}

.
Some more discussion refers to the two-dimensional case in order to characterize the range of the operator

J
2

{J_{2}}

.
Coupling of laser diode with cylindrical microlens fabricated on the tip of single-mode photonic crystal fiber: prediction of coupling optics by ABCD matrix
Authors: Majumdar Angshuman , Gangopadhyay Sankar 
Published: October 2023

Abstract
We report the theoretical prediction of the coupling optics involving a laser diode and photonic crystal fiber which contains on its tip cylindrical microlens. The analysis is based on relevant ABCD matrix formalism. Though photonic crystal fiber has very large single-mode region, we carry on the investigation for two commonly used wavelengths such as 1.3 µm and 1.5 µm. For the particular kind of photonic crystal having specific value of air filling ratio and hole pitch, we have optimized the distance of laser diode from the microlens in order to get maximum value of coupling efficiency for each value of radius of cylindrical microlens. Incidentally, we have got here maximum coupling efficiency to the extent of 86.99 % at the wavelength 1.3 µm when the radius of the cylindrical microlens is 8.5 µm and effective spot size of the fiber is 4.433909 µm. Further, the maximum efficiency becomes 91.78 % at 1.3 µm when the radius of the cylindrical microlens is 4.0 µm and effective spot size of the fiber is 1.859907 µm. It has been shown that wavelength 1.5 µm is not so coupling efficient like 1.3 µm. Moreover, it has been shown that with same set of relevant parameters, PCF is more coupling efficient compared to ordinary graded index fiber. Thus the present work generates scope for varying different photonic crystal fiber parameters and the wavelengths of source as well for enhancing the coupling efficiency. Accordingly, the present analysis will be extremely helpful for design of efficient coupler of this kind.
Bayesian approach for design and analysis of medical device trials in the era of modern clinical studies
Authors: Cao Han , Yao Chen , Yuan Ying 
Published: October 2023

Abstract
Medical device technology develops rapidly, and the life cycle of a medical device is much shorter than drugs. It is necessary to evaluate the safety and effectiveness of a medical device in a timely manner to keep up with technology flux. Bayesian methods provides an efficient approach to addressing this challenge. In this article, we review the characteristics of the Bayesian approach and some Bayesian designs that were commonly used in medical device regulatory setting, including Bayesian adaptive design, Bayesian diagnostic design, Bayesian multiregional design, and Bayesian label expansion study. We illustrate these designs with medical devices approved by the US Food and Drug Administration (FDA). We also review several innovative Bayesian information borrowing methods, and briefly discuss the challenges and future directions of the Bayesian application in medical device trials. Our objective is to promote the use of the Bayesian approach to accelerate the development of innovative medical devices and their accessibility to patients for effective disease diagnoses and treatments.
Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep
Authors: Fan Joline M. , Kudo Kiwamu , Verma Parul , Ranasinghe Kamalini G. , Morise Hirofumi , Findlay Anne M. , Vossel Keith , Kirsch Heidi E. , Raj Ashish , Krystal Andrew D. , Nagarajan Srikantan S. 
Published: October 2023

Sleep is a highly stereotyped phenomenon, requiring robust spatiotemporal coordination of neural activity. Understanding how the brain coordinates neural activity with sleep onset can provide insights into the physiological functions subserved by sleep and the pathologic phenomena associated with sleep onset. We quantified whole-brain network changes in synchrony and information flow during the transition from wakefulness to light non-rapid eye movement (NREM) sleep, using MEG imaging in a convenient sample of 14 healthy human participants (11 female; mean 63.4 years [SD 11.8 years]). We furthermore performed computational modeling to infer excitatory and inhibitory properties of local neural activity. The transition from wakefulness to light NREM was identified to be encoded in spatially and temporally specific patterns of long-range synchrony. Within the delta band, there was a global increase in connectivity from wakefulness to light NREM, which was highest in frontoparietal regions. Within the theta band, there was an increase in connectivity in fronto-parieto-occipital regions and a decrease in temporal regions from wakefulness to Stage 1 sleep. Patterns of information flow revealed that mesial frontal regions receive hierarchically organized inputs from broad cortical regions upon sleep onset, including direct inflow from occipital regions and indirect inflow via parieto-temporal regions within the delta frequency band. Finally, biophysical neural mass modeling demonstrated changes in the anterior-to-posterior distribution of cortical excitation-to-inhibition with increased excitation-to-inhibition model parameters in anterior regions in light NREM compared with wakefulness. Together, these findings uncover whole-brain corticocortical structure and the orchestration of local and long-range, frequency-specific cortical interactions in the sleep-wake transition.SIGNIFICANCE STATEMENTOur work uncovers spatiotemporal cortical structure of neural synchrony and information flow upon the transition from wakefulness to light non-rapid eye movement sleep. Mesial frontal regions were identified to receive hierarchically organized inputs from broad cortical regions, including both direct inputs from occipital regions and indirect inputs via the parieto-temporal regions within the delta frequency range. Biophysical neural mass modeling revealed a spatially heterogeneous, anterior-posterior distribution of cortical excitation-to-inhibition. Our findings shed light on the orchestration of local and long-range cortical neural structure that is fundamental to sleep onset, and support an emerging view of cortically driven regulation of sleep homeostasis.