bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of blood pressure by METTL3 via RUNX1b-eNOS pathway in endothelial cells
Authors: Zhang Yanhong , Yang Xiaoxiao , Lan Mei , Yuan Ze , Li Shuai , Liu Yangping , Han Cha , Ai Ding , Yang Yang , Zhu Yi , Li Bochuan 
Published: December 2023

AbstractBackgroundEndothelial cells regulate vascular tone to control the blood pressure (BP) by producing both relaxing and contracting factors. Previously, we identified methyltransferase-like 3 (METTL3), a primaryN6-methyladenosine (m6A) methyltransferase, as a key player in alleviating endothelial atherogenic progression. However, its involvement in BP regulation remains unclear.MethodsTo evaluate the role of METTL3in vivo, mice with EC specific METTL3 deficiency (EC-Mettl3KO) with or without Ang II infusion were used to create a hypertensive model. Functional and MeRIP sequencing analysis were performed to explore the mechanism of METTL3-mediated hypertension.ResultsWe observed a reduction in endothelial METTL3 activity by Ang IIin vitroandin vivo. Endothelial METTL3-deficient mice exhibited higher BP than controls, both before and after Ang II infusion. Through m6A sequencing and functional analysis, we identified m6A modification of various RUNX1 monomers resulted in endothelial dysfunction. Mutations in the 3′UTR region of RUNX1b abolished its luciferase reporter activity, and enhanced eNOS promoter luciferase reporter activity with or without METTL3 overexpression. Overexpression of METTL3 by adeno-associated virus reduced Ang II-induced BP elevation.ConclusionThis study reveals that METTL3 alleviates hypertension through m6A-dependent stabilization ofRUNX1bmRNA, leading to upregulation of eNOS, thus underscoring the pivotal role of RNA transcriptomics in the regulation of hypertension.
Basement membrane extract potentiates the endochondral ossification phenotype of bone marrow-derived mesenchymal stem cell-based cartilage organoids
Authors: Notoh Hinako , Yamasaki Satoshi , Suzuki Nobuaki , Suzuki Atsuo , Okamoto Shuichi , Kanematsu Takeshi , Suzuki Naruko , Katsumi Akira , Kojima Tetsuhito , Matsushita Tadashi , Tamura Shogo 
Published: December 2023

AbstractEndochondral ossification is a developmental process in the skeletal system and bone marrow of vertebrates. During endochondral ossification, primitive cartilaginous anlages derived from mesenchymal stem cells (MSCs) undergo vascular invasion and ossification.In vitroregeneration of endochondral ossification is beneficial for research on the skeletal system and bone marrow development as well as their clinical aspects. However, to achieve the regeneration of endochondral ossification, a stem cell-based artificial cartilage (cartilage organoid, Cart-Org) that possesses an endochondral ossification phenotype is required. Here, we modified a conventional 3D culture method to create stem cell-based Cart-Org by mixing it with a basement membrane extract (BME) and further characterized its chondrogenic and ossification properties. BME enlarged and matured the bone marrow MSC-based Cart-Orgs without any shape abnormalities. Histological analysis using Alcian blue staining showed that the production of cartilaginous extracellular matrices was enhanced in Cart-Org treated with BME. Transcriptome analysis using RNA sequencing revealed that BME altered the gene expression pattern of Cart-Org to a dominant chondrogenic state. BME triggered the activation of the SMAD pathway and inhibition of the NK-κB pathway, which resulted in the upregulation ofSOX9,COL2A1, andACANin Cart-Org. BME also facilitated the upregulation of genes associated with hypertrophic chondrocytes (IHH,PTH1R,andCOL10A1) and ossification (SP7,ALPL, andMMP13). Our findings indicate that BME promotes cartilaginous maturation and further ossification of bone marrow MSC-based Cart-Org, suggesting that Cart-Org treated with BME possesses the phenotype of endochondral ossification.HighlightsBasement membrane extract (BME) enlarges MSC-based Cart-Org.BME activates the SMAD pathway and inhibits the NK-kB pathway of the Cart-Org.BME promotes cartilaginous maturation and further ossification of Cart-Org.
A YIPF5-GOT1A/B complex directs a transcription-independent function of ATF6 in ER export
Authors: Cramer Paul , Yonemura Yoji , Behrendt Laura , Marszalek Aleksandra , Sannai Mara , Durso William , Günes Cagatay , Szafranski Karol , Nakamura Nobuhiro , Nasrashvili Tornike , Mayer Johanna , von Eyss Björn , Kaether Christoph 
Published: December 2023

AbstractExit from the endoplasmic reticulum is mediated by the Sar1/COPII machinery and a number of accessory factors. How the initial steps of cargo recruitment upstream of Sar1/COPII are mediated remains unclear, but the dihydropyridine FLI-06 inhibits cargo recruitment into ER exit sites. Here, we used chemical genetics screening approaches in conjunction with FLI-06 treatment and identified the ER membrane proteins YIPF5 and GOT1A/B as putative components of early export processes. Surprisingly, the two homologous proteins GOT1A and GOT1B, coded byGOLT1AandGOLT1B, respectively, exhibited opposite functions after treatment with FLI-06: increasing the expression of GOT1A or reducing the expression of GOT1B or YIPF5 prevented inhibition of ER-export by FLI-06. Inhibiting ER export with FLI-06 elicited a specific ER stress-related gene expression signature distinct from the ER-stress signature induced by Thapsigargin. The interactomes of GOT1A and GOT1B suggested a connection to ER-stress mediators. Moreover, RNA-Seq data showed that FLI-06-induced genes are strongly enriched for ATF6 target genes which are suppressed by GOLT1A overexpression or GOLT1B knock-down. This suggests that ATF6 signaling is involved in FLI-06-mediated toxicity, and we could demonstrate that siRNA-mediated knock-down or specific inhibitor of ATF6 rescued cells from FLI-06-mediated cell death. Knock-down or inhibition of ATF6 is sufficient to resume transport from the ER under FLI-06-treatment, suggesting that ATF6 is directly involved in the FLI-06-mediated ER-export block. Surprisingly, our data show that this ATF6 function is independent ofde novotranscription, implying a novel, transcription-independent function of ATF6.
Review on aviation intelligent self-healing anti-corrosion coating
Authors: Chen Yajun , Sui Zehuan , Du Juan 
Published: December 2023

Purpose
This paper aims to focus on the research progress of intelligent self-healing anti-corrosion coatings in the aviation field in the past few years. The paper provides certain literature review supports and development direction suggestions for future research on intelligent self-healing coatings in aviation.

Design/methodology/approach
This mini-review uses a systematic literature review process to provide a comprehensive and up-to-date review of intelligent self-healing anti-corrosion coatings that have been researched and applied in the field of aviation in recent years. In total, 64 articles published in journals in this field in the last few years were analysed in this paper.

Findings
The authors conclude that the incorporation of multiple external stimulus-response mechanisms makes the coatings smarter in addition to their original self-healing corrosion protection function. In the future, further research is still needed in the research and development of new coating materials, the synergistic release of multiple self-healing mechanisms, coating preparation technology and corrosion monitoring technology.

Originality/value
To the best of the authors’ knowledge, this is one of the few systematic literature reviews on intelligent self-healing anti-corrosion coatings in aviation. The authors provide a comprehensive overview of the topical issues of such coatings and present their views and opinions by discussing the opportunities and challenges that self-healing coatings will face in future development.
Fractal model of thermal contact conductance of rough surfaces based on axisymmetric cosinusoidal asperity
Authors: Sun Xianguang , Xin Xicheng 
Published: December 2023

Purpose
The purpose of this study is to propose a fractal model of thermal contact conductance of rough surfaces based on axisymmetric cosinusoidal asperity.

Design/methodology/approach
The effects of contact load, fractal dimension, fractal roughness and friction coefficient on the thermal contact conductance of rough surfaces were investigated in this study.

Findings
The findings suggest that as the contact load increases, the thermal contact conductance of rough surfaces also increases. In addition, an increase in the fractal dimension corresponds to an increase in the thermal contact conductance. Conversely, an increase in fractal roughness leads to a decrease in thermal contact conductance. The smaller the friction coefficient, the lower the thermal contact conductance of the rough surface. In practical engineering applications, it is possible to achieve the desired thermal contact conductance of rough surfaces by selecting surfaces with appropriate roughness.

Originality/value
A fractal model of thermal contact conductance of rough surfaces based on axisymmetric cosinusoidal asperity was established in this study. The findings of this study offer a theoretical foundation for investigating the thermal contact conductance of rough surfaces.
Intellectual capital, digital transformation and firm performance: evidence based on listed companies in the Chinese construction industry
Authors: Zhang Yang , Li Hui , Yao Zeliang 
Published: December 2023

PurposeThe study aims to investigate the effects of intellectual capital and its constituents on the performance of listed companies operating in China's construction sector. The study also intends to examine the moderating role of digital transformation.Design/methodology/approachHypotheses will be tested using Modified Value-Added Intellectual Capital (MVAIC). The sample will be comprised of 93 Shenzhen and Shanghai A-share listed companies within the construction industry from the period of 2015–2021. Multiple regression analysis was employed to investigate the influence of intellectual capital, its components and digital transformation on the performance of construction firms.FindingsThe study's results reveal that the performance of construction firms greatly depends on intellectual capital and its components. Furthermore, digital transformation plays a vital moderating role between intellectual capital and its components and construction firm performance.Practical implicationsThis study addresses a critical inquiry on how construction managers can employ intellectual capital to enhance the performance of firms during digital transformation. Additionally, this research bridges this gap by guiding construction managers to concentrate on their external surroundings when examining firm performance.Originality/valueBy focusing on the predictors influencing construction firms' performance, this study contributes to the existing corpus of knowledge. This study employs resource orchestration theory (ROT) to determine how the different components of intellectual capital impact the performance of construction firms, with digital transformation acting as a moderating variable. This research will be valuable to researchers, construction industry professionals and policymakers.
What and how influence the safety knowledge sharing of new generation of construction workers in China: a study based on DEMATEL and ISM
Authors: Ni Guodong , Zhou Qi , Miao Xinyue , Niu Miaomiao , Zheng Yuzhuo , Zhu Yuanyuan , Ni Guoxuan 
Published: December 2023

PurposeNew generation of construction workers (NGCWs) who were born in the 1980s and later have gradually become the main workforce of Chinese construction industry. They may behave differently when dealing with knowledge-related activities due to divergent characteristics caused by generational discrepancy. To provide a theoretical foundation for construction companies and safety managers to improve safety management, this research explores the factors and paths impacting the NGCWs' ability to share their safety knowledge.Design/methodology/approachBased on literature review, main factors that influence the safety knowledge sharing of the NGCWs were identified. Decision-Making Trial and Evaluation Laboratory and Interpretive Structural Modeling were applied to identify the hierarchical and contextual relations among the factors influencing the safety knowledge sharing of the NGCWs.FindingsThe results showed that sharing atmosphere ranked first in centrality and had a high degree of influence and being influenced, indicating itself an extremely important influencing factor of safety knowledge sharing of NGCWs. Six root influencing factors were identified, including individual characteristics, work pressure, sharing platform, incentive mechanism, leadership support and safety management system.Research limitations/implicationsThe number of influencing factors of safety knowledge sharing of the NGCWs identified in this study is limited, and the data obtained by the expert scoring method is subjective. In future studies, the model should be further developed and validated by incorporating experts from different fields to improve its integrity and applicability.Practical implicationsThe influencing factors identified in this paper can provide a basis for construction companies and safety managers to improve productivity and safety management by taking relevant measures to promote safety knowledge sharing. The research contributes to the understanding knowledge management in the context of the emerging market. It helps to answer the question of how the market can maintain the economic growth success through effective knowledge management.Originality/valueThis paper investigates the influencing factors of NGCWs' safety knowledge sharing from the perspective of intergenerational differences, and the 13 influencing factor index system established expands the scope of research on factors influencing safety knowledge sharing among construction workers and fills the gap in safety knowledge sharing research on young construction workers. Furthermore, this paper establishes a multi-layer recursive structure model to clarify the influence path of the influencing factors and contributes to the understanding of safety knowledge sharing mechanism.
Predicting students' soft skills: the role of psychological capital, psychological well-being and grade levels
Authors: Saman Abdul , Wirawan Hillman 
Published: December 2023

PurposeSoft skills are essential not only for students but also for employees in any workplace. Some factors influence the development of soft skills in high schools. This study investigates the effect of psychological capital (PsyCap) on soft skills through the role of psychological well-being at different students’ grade levels.Design/methodology/approachThree scales (i.e. the Psychological Capital Questionnaire, the Scale of Psychological Well-being and the soft skills assessment) were used on 707 high school students from seven senior high schools. The data were analysed using a moderated-mediation regression technique to reveal the conditional indirect effect of PsyCap on soft skills.FindingsThe results suggested that students' grade levels moderated the indirect effect of PsyCap on soft skills via psychological well-being. Students in higher grades showed a stronger impact of PsyCap on soft skills via psychological well-being.Research limitations/implicationsThe psychological states of students should be regarded as one of the most critical aspects of education and career advancement. Schools should assist students in developing their soft skills. Students, regardless of grade level, would begin to occupy their PsyCap, ensure their psychological well-being and finally, engage in soft skills development activities.Originality/valueThis current study has shifted from simply assessing soft skills to investigating some avenues for developing soft skills in various contexts and areas. If the theoretical model is well established, teachers and educators can effectively improve soft skills intervention by understanding the antecedents of soft skills.
Scale to measure project resilience for the construction sector to cope with hazards
Authors: Rahi Khalil , Abu Baker Faris , Preece Christopher , Abu Jadayil Wisam 
Published: December 2023

Purpose
The purpose of this study is to test and validate a scale for measuring project resilience in the construction sector within the built environment. By identifying relevant indicators and items, the study aims to enhance the resilience of construction projects and minimize losses and failures resulting from disruptive events such as societal, technological, biological and environmental hazards (e.g. Covid-19, war in Ukraine, shortage of resources, etc.).

Design/methodology/approach
The study uses a quantitative approach, specifically exploratory factor analysis and confirmatory factor analysis, to evaluate the suitability, dimensionality and reliability of the proposed indicators and items for measuring project resilience in the construction sector.

Findings
The study found that 9 indicators and 34 items were suitable for measuring project resilience in the construction sector, and the proposed model showed good fit for the two dimensions of project resilience, which may have practical implications for project managers in the construction sector within the built environment.

Originality/value
The study proposes a new scale for measuring project resilience in the construction sector, which is a novel contribution to the field of project management. The study identifies specific indicators and items that are relevant to this industry, which may have practical implications for project managers in this sector. The study also highlights the need for further research to make the project resilience scale more robust and reliable.
The accreditation paradigm: a comparative analysis of accreditations for management programmes
Authors: Reddy J. Srikanth , Sharma Ritu , Gupta Narain 
Published: December 2023

PurposeThe present paper concerns the domestic and international accreditations of business schools to find the commonalities in various accreditation standards. The study also addresses cost involvement and comparisons between various accreditations.Design/methodology/approachThe research examined the requirements, methods and preparations for many national and international accrediting authorities. The accreditation criteria, history and guidelines were collected from secondary data sources. The content analysis was used to draw conclusions about the similarities and differences between the data sources and identify any differences and similarities between various accreditations.FindingsThe study found commonalities across accreditation standards and cost analyses, helping institutions achieve suitable accreditations. To unify the administrative procedure at the institutional level and reduce duplicates for schools seeking multiple accreditations, similarities in all accreditation requirements are analysed. The comparison helps organisations determine which accreditation standard best suits their needs and goals. Schools with limited budgets might compare accreditation costs to determine which are worth pursuing.Research limitations/implicationsThis study is limited to comparing a few accreditation bodies related to management education. In future research, the study may be extended to other areas. The use of the approach developed in this study for evaluating accreditation agencies of different streams, such as engineering, science and medicine, will be the study's future implications.Practical implicationsThe research indicates that schools can streamline accreditation by identifying commonalities, aligning procedures, comparing standards and conducting cost assessments. These insights aid efficient accreditation and inform accrediting bodies' framework enhancements. Standards facilitate global performance comparisons.Originality/valueThis is likely the first study to compare Indian and international accreditations using the accreditation frameworks and cost analyses using comparative analysis. The study recommends strategies for achieving academic benchmarks through continuous improvement activities and success in international competition.
Interpersonal deviance, organizational deviance and socio-emotional factors at work: the role of socio-demographic traits
Authors: Abas Basit , Vo-Thanh Tan , Bukhari Shazia , Villivalam Srikanth , Senbeto Dagnachew Leta 
Published: December 2023

PurposeThe existing hospitality and tourism literature indicates a discrepancy in the findings related to the socio-demographic variables' impact on hotel employees' socio-emotional factors and behavioral outcomes. This study aims to provide a comprehensive understanding of this topic.Design/methodology/approachUsing a questionnaire, primary data were gathered from hotel employees in the Union Territory of Jammu and Kashmir, India from February to June 2022. A total of 416 valid responses collected through offline mode were used in the data analysis. Multiple linear regressions were done using SPSS V.29.FindingsThe findings show that the socio-demographic characteristics of respondents significantly affect socio-emotional factors at work as well as interpersonal deviance and organizational deviance.Practical implicationsPolicymakers and hotel managers can implement training and development programs that assist hotel employees with diversified socio-demographic attributes in handling stress, developing their emotional intelligence and minimizing workplace deviance. The study also provides hotel managers with actional recommendations to reduce work–family conflict, social disparity among employees and their emotional exhaustion.Originality/valueThe study adds to the literature with a comprehensive framework regarding the role of various socio-demographic traits in fostering interpersonal deviance, organizational deviance and socio-emotional factors at work.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-04-2023-0304
At what age do Mexicans suffer the most financial stress?
Authors: García Mata Osvaldo 
Published: December 2023

PurposeNeeds change as people get older. Procuring resources to satisfy them can generate anguish and insecurities in consumers due to their financial situation. This study aims to analyze the relationship between age and financial stress among Mexican adults and estimate the age of their maximum financial stress.Design/methodology/approachThis study is based on constructing a financial stress indicator using the confirmatory factor analysis and linear regression models with a quadratic term, employing data from the National Survey on Financial Inclusion 2021.FindingsResults show that the relationship between age and financial stress follows a quadratic pattern, with a maximum level at age 56, which varies according to sex, marital status, number of dependents, education and regions. These findings interest financial product designers and policy developers who aim to improve consumers' well-being.Research limitations/implicationsLongitudinal studies and indicators, such as financial fragility, are needed to facilitate refining models over time.Originality/valueThere is no evidence of studies that have addressed the age of maximum financial stress in Latin America. Doing so is relevant because identifying the stages in life when adults are most vulnerable to financial stress helps assess its causes more precisely, thus mitigating its adverse effects.