bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico, anti-inflammatory and acute toxicological evaluation of an indigenous medicinal plant Pterospermum rubiginosum using Sprague-Dawley rats
Authors: Anish Rajamohanan Jalaja , Nair Aswathy , Saraswathy V. , Kalpana Velappan Nair S. , Shyma Rajendran L. 
Published: February 2024

Abstract
Background
Pterospermum rubiginosum has been traditionally used by the tribal inhabitants of Southern India for treating bone fractures and as a local anti-inflammatory agent; however, experimental evidence to support this traditional usage is lacking. The present study aimed to investigate the phytochemical characterization, in silico and in vitro anti-inflammatory evaluation, followed by in vivo toxicological screening of P. rubiginosum methanolic bark extract (PRME).

Results
The LCMS evaluation revealed the presence of 80 significant peaks; nearly 50 molecules were identified using the LCMS database. In silico analysis showed notable interactions with inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6). In vitro gene expression study supported the docking results with significant down-regulation of iNOS, IL-6, and IL-10. PRME was administered orally to the SD rats and was found to be non-toxic up to 1000 mg/kg body weight for 14 days. The antioxidant enzymes catalase and sodium dismutase exhibited an increased value in PRME-administered groups, possibly due to the diverse phytochemical combinations in bark extract.

Conclusions
PRME administration significantly downregulated the gene expression of inflammatory markers, such as iNOS, IL-6, and IL-10. The molecular docking analysis of iNOS and IL-6 supports the in vitro study. In vivo toxicological study of PRME in SD rats was found to be non-toxic up to a concentration of 1000 mg/kg body weight for 14 days.

Graphical abstract
Overall Survival From the EORTC LCG-1613 APPLE Trial of Osimertinib Versus Gefitinib Followed by Osimertinib in Advanced EGFR-Mutant Non–Small-Cell Lung Cancer
Authors: Remon Jordi , Besse Benjamin , Aix Santiago Ponce , Callejo Ana , Al-Rabi Kamal , Bernabe Reyes , Greillier Laurent , Majem Margarita , Reguart Noemi , Monnet Isabelle , Cousin Sophie , Garrido Pilar , Robinet Gilles , Campelo Rosario Garcia , Madroszyk Anne , Mazières Julien , Curcio Hubert , Wasąg Bartosz , Pretzenbacher Yassin , Grillet Fanny , Dingemans Anne-Marie C. , Dziadziuszko Rafal 
Published: February 2024

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. Osimertinib has been established as a standard of care for patients with common sensitizing EGFR-mutant advanced non–small-cell lung cancer (NSCLC) although the sequential approach (first-generation inhibitor gefitinib followed by osimertinib) has not been formally compared. The phase II APPLE trial (ClinicalTrials.gov identifier: NCT02856893 ) enrolled 156 treatment-naïve patients, and two treatment strategies were evaluated: osimertinib up front or the sequential treatment approach with gefitinib up front followed by osimertinib at the time of progression, either molecular progression (detection of plasma T790M resistance mutation) regardless of the radiologic status or just at the time of radiologic progression. Patients' characteristics were well balanced, except for the higher proportion of baseline brain metastases in the sequential approach (29% v 19%). Per protocol, 73% of patients switched to osimertinib in the sequential arm. Up-front treatment with osimertinib was associated with a lower risk of brain progression versus the sequential approach (hazard ratio [HR], 0.54 [90% CI, 0.34 to 0.86]), but a comparable overall survival was observed between both strategies (HR, 1.01 [90% CI, 0.61 to 1.68]), with the 18-month survival probability of 84% and 82.3%, respectively. The APPLE trial suggests that a sequential treatment approach is associated with more frequent progression in the brain but a similar survival in advanced EGFR-mutant NSCLC.
Comparison of rapid and conventional methods for investigating of mecA presence in Staphylococcus Species
Authors: TAŞKIN MEHMET HAKAN 
Published: February 2024

doi: https://doi.org/10.12669/pjms.40.4.9284
How to cite this: Taskin MH. Comparison of rapid and conventional methods for investigating of mecA presence in Staphylococcus Species. Pak J Med Sci. 2024;40(4):794-795. doi: https://doi.org/10.12669/pjms.40.4.9284
Review of available therapies for the treatment of pediatric COVID-19-associated polyarticular inflammatory syndrome
Authors: Leśniewski Michał 
Published: February 2024

Recently, there have been an increasing number of reports from around the world describing children and adolescents with multisystemic inflammatory conditions associated with COVID-19. The clinical features of these pediatric cases are both similar to and different from other well-described inflammatory syndromes, including Kawasaki disease. Symptoms appear to develop after infection, rather than in the acute phase of COVID-19. Regarding the clinical spectrum, much remains unknown.
The new disease entity challenges specialists around the world in developing universal management protocols. In the fight for the health and lives of patients, treatment according to standard protocols for Kawasaki disease has been used. However, further clinical trials are required to prove the effectiveness and safety of these treatments. There are reports of successful therapy using intravenous immunoglobulin preparations and steroid therapy. Biologic, antiviral, antibiotic, antiplatelet and anticoagulant therapies are also used. The described pediatric disease can be associated with hemodynamic failure, so treatment should take place in a hospital setting, under the watchful eye of a multidisciplinary team.
Percepção dos profissionais de saúde sobre a relevância do acolhimento para a gestão do cuidado na Atenção Primária à Saúde
Authors: Silva Tarciso Feijó da , Ramos Tatiana Cabral da Silva , Nascimento Vagner Ferreira do , Silva Pedro Henrique Souza , Vaz Ismael Fabrício 
Published: February 2024

Objetivo: identificar a partir da percepção dos profissionais de saúde qual a relevância do acolhimento para a gestão do cuidado na Atenção Primária à Saúde. Método: estudo descritivo e exploratório desenvolvido com 17 profissionais de uma unidade de Atenção Primária à Saúde do município do Rio de Janeiro. Os dados foram coletados por meio da entrevista narrativa e a análise de conteúdo dos dados com o auxílio do ATLAS ti 7.1.8. Resultados: apesar dos profissionais atuarem no campo há mais de 3 anos e de suas práticas serem permeadas pelo vínculo, as percepções sobre o acolhimento foram distintas, sendo observado como dispositivo para organização do processo de trabalho, como ferramenta para orientação do acesso e das demandas e como estratégia de vigilância em saúde para produção do cuidado. Conclusão: a utilização que o profissional faz do acolhimento no âmbito da Atenção Primária à Saúde acaba sendo ditada pelos fluxos e processos instituídos pela gestão, o que pode influir diretamente no acesso, no trabalho em equipe e na produção do cuidado em saúde.
WO3/Pt/PEG/SiO2 porous film for hydrogen sensing by the sol-gel method
Authors: Chu FengHong , Pei Dan , Bian ZhengLan , Sun YiSheng , Hu AnDuo , Zhang GuiLin , Xue Liang , Han JiaWen , Zhang JiaMeng 
Published: February 2024

Tungsten oxide (WO3) has been widely used in hydrogen sensing due to its stable chemical properties and high oxygen vacancy diffusion coefficient. However, the response of pure WO3 to hydrogen is slow, and doping is an effective way to improve the hydrogen sensing performance of WO3 materials. In this paper, WO3/Pt/PEG/SiO2 porous film was prepared by the sol-gel method using tungsten powder, H2O2 and C2H5OH as precursors, polyethylene glycol (PEG) as the pore-forming agent, and tetraethyl orthosilicate (TEOS) as the SiO2 source material. The sensing properties of the WO3 composite for hydrogen were characterized by a transmission optical fiber hydrogen sensing system made at home. The process parameters such as water bath time, aging time, W:PEG ratio, and W:TEOS ratio were optimized to improve the sensitivity and response time of the sensing film. The experimental results indicate that the sensitivity is 15.68%, the average response time is 45 s, and the repeatability is up to 98.74% in 16 consecutive tests. The linearity index R2 is 0.9946 within the hydrogen concentration range of 5000 ppm to 50,000 ppm. The film responds only to H2 when the concentration of interfering gases (CH4, CO, CO2) is 2000 ppm. The hydrogen sensing performance of the optimized film is significantly improved compared with that of the undoped film.
VO2 wire grid polarizers for MWIR applications
Authors: Lawandi Roseanna G. , Morden Dylan , Agha Imad , Vangala Shivashankar , Sarangan Andrew M. 
Published: February 2024

Phase change materials (PCMs) have received a lot of attention recently due to their
ability to reversibly switch between phases producing large changes in
their optical and electrical properties.VO2 is unique compared to other
chalcogenide-based PCMs due to its volatile switching behavior,
allowing it to automatically reset when the thermal stimulus is
removed. It is able to switch between a metallic rutile phase and a
monoclinic semiconducting phase, making it an ideal candidate for
polarization control. In this paper, we demonstrate a VO2 wire grid polarizer with an
extinction ratio as high as 6 dB in the midwave infrared (MWIR)
spectrum that can be thermally turned on and off. We used a novel, to
the best of our knowledge, approach to fabricate these devices, using
conventional photolithography and lift-off processes on metallic
vanadium followed by thermal oxidation in a furnace. This is a
significantly simpler and a scalable procedure compared to current
processes of patterning and etching VO2.
FEATURES OF THE DEVELOPMENT OF CROSS-BORDER TRADE BETWEEN RUSSIA AND CHINA IN MODERN CONDITIONS
Authors: Obiremko S. I. , Ivanova M. Yu. , Zhang Jian 
Published: February 2024

The article discusses theoretical issues and some practical aspects of the development of cross-border trade. To understand the strategic importance of cross-border trade at the present stage of transformation of international economic relations, materials describing the state of cross-border trade between the Russian Federation and the People's Republic of China were used.
In the theoretical part of the article, attention is drawn to the diversity of approaches to the definition of «cross-border trade», understanding the importance of rapidly developing elements of the structure of crossborder trade. The authors state the state of development of institutional aspects of bilateral trade relations between Russia and China, as a convergence of positions on key issues of legislation and taxation, product certification and customs regulations.
Much attention is paid to the practical confirmation of the irreversibility of some trends in the formation of the economic foundations of a multipolar world.
In the practical part, the most important problems of logistics and management of cross-border trade are investigated.
IMPLEMENTASI PEMBERLAKUAN TAX AMNESTY DI KANTOR PELAYANAN PAJAK PRATAMA SEMARANG TENGAH SATU
Authors: Sari Hafizhah Mayang , Sa’adah Nabitatus , Juliani Henny 
Published: February 2024

Tax amnesty adalah program pengampunan yang diberikan oleh Pemerintah kepada Wajib Pajak meliputi penghapusan pajak yang seharusnya terutang, penghapusan sanksi administrasi perpajakan, serta penghapusan sanksi pidana di bidang perpajakan atas harta yang diperoleh pada tahun 2015 dan sebelumnya yang belum dilaporkan dalam Surat Pemberitahuan Tahunan (SPT), dengan cara melunasi seluruh tunggakan pajak yang dimiliki dan membayar uang tebusan. Permasalahan yang diangkat dalam penulisan hukum ini adalah mengenai bagaimana implementasi dan tingkat keberhasilan pemberlakuan tax amnesty di Kantor Pelayanan Pajak (KPP) Pratama Semarang Tengah Satu, kendala apa saja yang dihadapi dan bagaimana upaya untuk mengatasi kendala-kendala yang timbul selama pelaksanaan tax amnesty di Kantor Pelayanan Pajak (KPP) Pratama Semarang Tengah Satu. Metode pendekatan dalam penelitian ini menggunakan pendekatan yuridis empiris. Untuk mendekati pokok masalah penulisan, spesifikasi penulisan yang digunakan adalah deskriptif analitis. Data diperoleh dari data primer yang dilakukan dengan cara wawancara dan data sekunder yang bersumber dari penelitian kepustakaan serta metode analisis yang digunakan bersifat kualitatif. Hasil penelitian dapat diketahui bahwa pelaksanaan kebijakan tax amnesty di Kantor Pelayanan Pajak (KPP) Pratama Semarang tengah Satu dapat meningkatkan jumlah Wajib Pajak yang terdaftar baik Wajib Pajak Orang Pribadi maupun Wajib Pajak Badan dan meningkatkan penerimaan negara melalui pemasukan uang tebusan.Kendala-kendala selama pelaksanaan tax amnesty yaitu perubahan peraturan atau adanya tambahan peraturan baru mengenai kebijakan tax amnesty yang tidak diketahui Wajib Pajak, kekurangan jumlah petugas pajak, dan format penyerahan softcopy Surat Pengakuan Harta (SPH) oleh Wajib Pajak yang tidak sesuai. Upaya untuk mengatasi kendala tersebut adalah dengan petugas helpdesk selalu memberitahukan tentang adanya perubahan peraturan atau tambahan peraturan-peraturan baru, pembagian pegawai di Kantor Pelayanan Pajak (KPP) Pratama Semarang Tengah Satu dalam tim yang mengurus mengenai tax amnesty dan tim yang mengurus pekerjaan rutin, petugas helpdesk selalu memberikan edukasi kepada Wajib Pajak mengenai cara pengisian formulir Surat Pengakuan Harta (SPH) yang benar, dan petugas pajak berusaha memberikan layanan prima selama periode kebijakan tax amnesty berlangsung tanpa mengabaikan tugas pokok.
Cardiopulmonary exercise testing in younger patients with persistent dyspnea following acute, outpatient COVID‐19 infection
Authors: Holley Aaron B. , Fabyan Kimberly D. , Haynes Zachary A. , Holtzclaw Arthur W. , Huprikar Nikhil A. , Shumar John N. , Sheth Phorum S. , Hightower Stephanie L. 
Published: February 2024

AbstractStudies using cardiopulmonary exercise testing (CPET) to evaluate persistent dyspnea following infection with COVID‐19 have focused on older patients with co‐morbid diseases who are post‐hospitalization. Less attention has been given to younger patients with post‐COVID‐19 dyspnea treated as outpatients for their acute infection. We sought to determine causes of persistent dyspnea in younger patients recovering from acute COVID‐19 infection that did not require hospitalization. We collected data on all post‐COVID‐19 patients who underwent CPET in our clinic in the calendar year 2021. Data on cardiac function and respiratory response were abstracted, and diagnoses were assigned using established criteria. CPET data on 45 patients (238.3 ± 124 days post‐test positivity) with a median age of 27.0 (22.0–40.0) were available for analysis. All but two (95.6%) were active‐duty service members. The group showed substantial loss of aerobic capacity—average VO2 peak (L/min) was 84.2 ± 23% predicted and 25 (55.2%) were below the threshold for normal. Spirometry, diffusion capacity, high‐resolution computed tomography, and echocardiogram were largely normal and were not correlated with VO2peak. The two most common contributors to dyspnea and exercise limitation following comprehensive evaluation were deconditioning and dysfunctional breathing (DB). Younger active‐duty military patients with persistent dyspnea following outpatient COVID‐19 infection show a substantial reduction in aerobic capacity that is not driven by structural cardiopulmonary disease. Deconditioning and DB breathing are common contributors to their exercise limitation. The chronicity and severity of symptoms accompanied by DB could be consistent with an underlying myopathy in some patients, a disorder that cannot be differentiated from deconditioning using non‐invasive CPET.
Metasurface absorber enhanced thermoelectric conversion
Authors: Nakayama Ryosuke , Saito Sohei , Tanaka Takuo , Kubo Wakana 
Published: February 2024

Abstract
Metasurfaces are artificial thin materials that achieve optical thickness through thin geometrical structure. This feature of metasurfaces results in unprecedented benefits for enhancing the performance of optoelectronic devices. In this study, we report that this metasurface feature is also essential to drive photo-thermoelectric conversion, which requires the accumulation of thermal energy and effective heat conduction. For example, a metasurface-attached thermoelectric device placed in an environment with uniform thermal radiation generates an output voltage by gathering the thermal energies existing in the environment and creating an additional thermal gradient across the thermoelectric element. In contrast, when a 100-μm-thick-carbon-black-coated electrode was used instead of the metasurface, the device showed lower thermoelectric performance than that of the metasurface-attached device although carbon black exhibits higher infrared absorption than the metasurface. These results indicate that metasurface characteristics of optical thickness and thin geometrical structure for achieving the high thermal conductance are essential in enhancing the performance of photo-thermoelectric devices in terms of the effective collection of thermal energies and conduction of local heating.
ОПЕРАТИВНИЙ КОНТРОЛЬ ФУНКЦІОНАЛЬНИХ ПОКАЗНИКІВ У СИЛОВИХ ВИДАХ СПОРТУ
Authors: Мочернюк Владислав , Завадяк Іван , Мартин Володимир 
Published: February 2024

Мета дослідження – аналіз даних оперативного контролю та діагностика функціональних станів представників силових видів спорту. Матеріал і методи дослідження: Визначались абсолютні розміри довжина тіла, обхвати грудей і талії та співвідношення талії до обхвату стегон та до обхвату грудної клітки, застосувався біоімпедантний аналізу в поєднанні з контролем діяльності серцево-судинної системи серед представників силових видів спорту Прикарпаття. Результати. Встановлено високу частку молодих спортсменів важкоатлетів та пауерліфтерів з надмірною власною вагою та показниками вісцерального жиру, перевищенням біологічного віку над паспортним на понад 10 років, високими показниками АТ і ЧСС.
Висновки: Виявлено негативний вплив надмірної маси тіла та високого вмісту жирового компоненту на динаміку ЧСС та АТ під час тренувань.
Estrés académico y clima organizacional en estudiantes universitarios de una universidad pública en Perú en pospandemia Covid-19
Authors: López-Armes Edy Luisa , Javier-Ninahuaman Henry Juan 
Published: February 2024

Con la COVID 19 se ha evidenciado que los estudiantes universitarios se han visto afectados en el aspecto psicológico que a su vez fue reflejada en reacciones fisiológicas, emocionales, cognitivas y conductuales, ¿Tendrá el clima organizacional de la universidad importancia para estos aspectos? El objetivo del presente trabajo de investigación, fue determinar la relación entre el estrés académico y el clima organizacional en los estudiantes de la Unidad Académica de Estudios Generales de una universidad pública en pospandemia COVID 19. Como metodología se empleó la investigación aplicada, nivel descriptivo, diseño correlacional, enfoque cuantitativo y, la técnica encuesta, además se propuso un modelo de interacción de variables por ecuaciones estructural SEM por análisis factorial exploratorio de los componentes. Se aplicaron los instrumentos Inventario de SISCO de estrés académico y clima organizacional en escala ordinal a una muestra de 1 427 estudiantes de una población de 1 500. Los resultados obtenidos indican que existe relación inversa débil y significativa entre estrés académico y clima organizacional en la muestra analizada (rho de Spearman =-0.13; sig= 5%), además que el afrontamiento y los síntomas (S) del estrés inciden en el diseño organizacional universitario (DO), y que DO influencia a la cultura organizacional (CUO) y el potencial humano (PH) del estudiante; los estresores afectan a PH, S y el clima organizacional.
Fast-activating reserve power sources: is lead dead indeed?
Authors: Shcheglov Pavel A. , Samsonov Dmitry A. , Pavlenkov Anatoly B. , Kulova Tatiana L. , Rychagov Alexey Yu. , Skundin Alexander M. , Postnova Evgeniya Yu. 
Published: February 2024

The purpose of this research is to improve the performance and reduce the activation time of reserve power sources based on lead-acid systems at lower temperatures, down to –50 °C. Physico-chemical factors affecting the activation speed of reserve power sources based on Pb–HClO4–PbO2 and Zn–HClO4–PbO2 systems are investigated using chronopotentiometry, scanning electron microscopy, and standard contact porosimetry. Two approaches to the improvement of the low-temperature performance of power sources are used. The first one is based on the substitution of lead as anodic material with zinc. This allows the increase in discharge voltage and simultaneous decrease in activation time, but brings about the instability of discharge characteristics and, finally, deteriorates the reliability of power sources. The second approach is based on the use of PbO2 cathode material with enhanced nanoporosity. The chronopotentiometric method in galvanostatic mode is applied to the quality estimation of cathodes. The criterion of applicability of cathodes for reserve power sources consists in the low discharge overvoltage (0.1–0.2 V). Efficient performance of reserve power sources possessing the stable discharge voltage (1.5–1.8 V per cell) and the unprecedentedly short activation time (under 30 ms) even at lower temperatures (down to –50 °C) is achieved. The results are verified by fabrication and testing of pilot batches of miniaturized reserve power sources having microcells’ volume of 0.02 ml. The second approach to the improvement of power sources is transferred into the industrial production.
Actividad física y conducta sedentaria en estudiantes de primer ciclo de educación infantil.
Authors: Díaz Gema , Navarro-Rueda María Inés , Torres-Luque Gema 
Published: February 2024

El objetivo de este trabajo fue: a) analizar el cumplimiento de las recomendaciones de actividad física y comportamiento sedentario en sujetos de primer ciclo de educación infantil, en relación al género, y; b) determinar las posibles diferencias en cuanto al comportamiento sedentario en horario escolar versus horario extraescolar. Se seleccionaron 73 escolares de primer ciclo de Educación Infantil (2.12±0.46 años). Los participantes llevaron puesto durante 5 días consecutivos (lunes a viernes), un acelerómetro (Actigraph GT3X; Actigraph, Pensacola, FL, USA), que registró el nivel de actividad física moderada-vigorosa (AFMV) (min/día), el volumen de pasos, la conducta sedentaria (min/día) y el número de Bouts de conducta sedentaria (10, 20 y 30 min) de lunes a viernes; así como en Horario Escolar vs Horario Extraescolar. Los resultados indican un cumplimiento medio de las recomendaciones de AFMV (entorno al 50%), para estas edades, existiendo una tendencia a ser más alto en los chicos. Además, se observa una alta conducta sedentaria en los diferentes momentos evaluados, aunque destaca que la misma es significativamente menor en el Horario Escolar vs Horario Extraescolar. Este estudio puede contribuir a generar programas de intervención que contribuyan a un incremento de la AF y descender el tiempo en conducta sedentaria.