bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMBANGUNAN MANUSIA DALAM PERSPEKTIF EKONOMI ISLAM UNTUK MENCAPAI FALAH
Authors: Jaya Arisman 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui tentang pembangunan manusia dalam perspektif ekonomi islam. Pembangunan manusia dipandang sebagai proses perluasan pilihan dalam hidup manusia atau peningkatan kualitas hidup manusia. Adapun dimensi pembangunan manusia tersebut adalah pendidikan, kesehatan dan hidup yang layak. Ketiga dimensi tersebut merupakan hal yang esensial dalam kehidupan. Ekonomi islam sebagai suatu sistem prekonomian bertujuan untuk menghantarkan manusia untuk mencapai falah. Berdasarkan pada tujuan penelitian, maka pendekatan penelitan yang digunakan adalah penelitian kualitatif. Penelitan ini menggunakan dokumentasi dalam mengumpulkan data yang dipublikasikan dan beserta literasi-literasi yang terkait dengan penelitian. Data yang telah terkumpul kemudian dideskripsikan dengan menggunakan analisis deskriptif. Hasil penilitian ini adalah pembangunan manusia dalam ekonomi islam merupakan pembangunan sumber daya manusia yang religius. Dimana tidak hanya berorientasi pada kepentingan dunia semata, mereka akan menyeimbangkanya dengan akhirat untuk mencapai falah.
ANALISIS DESKRIPTIF GAYA KEPEMIMPINAN DAN FAKTOR-FAKTOR YANG MEMPENGARUHI KINERJA KARYAWAN PADA PABRIK GULA PT. PERKEBUNAN NUSANTARA XIV (PERSERO) KABUPATEN BONE
Authors: Irmayani Irmayani 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui gambaran penerapan gaya kepemimpinan dan faktor-faktor yang mempengaruhi kinerja karyawan pada pada pabrik gula PT. Perkebunan Nusantara XIV (persero) Kabupaten Bone. Penulis menggunakan metode field research (penelitian lapangan) dengan melakukan observasi, wawancara, dokumentasi dan kuisioner untuk memperoleh data dari masalah tersebut,. Selanjutnya dalam menganalisis data, penulis melalui tiga tahap kegiatan yaitu seleksi data, klasifikasi data, dan sistematika data. Hasil penelitian menunjukkan bahwa berdasarkan mean (rata-rata) dari 20 responden dan diberikan 10 pertanyaan dalam bentuk kuisioner yang terdiri 5 pertanyaan untuk variable gaya kepemimpinan berdasarkan dari rata-rata tersebut maka sangat jelas bahwa pemimpin menerapkan gaya kepemimpinan dalam pengembangan keputusan. Sedangkan faktor-faktor yang mempengaruhi kinerja karyawan adalah sikap disiplin, motivasi kerja, kompensasi atau insentif, gaya kepemimpinan, lingkungan kerja, pelatihan terhadap karyawan, perkembangan teknologi, delegasi tugas, dan komunikasi yang kuat.
Penentuan Tingkat Kerusakan Pantai Air Kodok, Desa Hatu - Pulau Ambon
Authors: Lilipory Isak , Pattiselanno Steanly R.R. 
Published: February 2024

Pola pengembangan dan penempatan infrastruktur di sepanjang pesisir pantai yang diterapkan di Pulau Ambon, selain menyajikan daya tarik yang luar biasa, juga menyimpan potensi kerawanan yang tinggi. Karena infrastruktur yang dibangun akan terdampak langsung menghadapi daya rusak alam lewat kondisi perairan pantai saat tejadi gelombang yang besar. Akibatnya adalah abrasi, erosi, ataupun sedimentasi yang langsung mempengaruhi morfologi pantai.
Hal ini juga yang terjadi pada Pantai Air Kodok Desa Hatu yang terletak pada posisi bentang koordinat -3.7219 BT, 128.0636 LS sampai dengan Pantai Waikiri pada koordinat -3.7243 BT, 128.0606 LS, di mana pada daerah pantai Desa Hatu adanya objek vital seperti Aproach Light (Lampu Pendaratan Pesawat), jalan provinsi yang menghubungan akses msayarakat dari Hatu, Liliboi dan Allang ke Kota Ambon, serta pemukiman penduduk yang masuk area sempadan pantai. Fenomena tersebut, menarik untuk didalami terhadap besarnya dampak yang terjadi, dan salah satu alat ukur yang dapat digunakan untuk menilai kriteria kerusakan daerah pantai adalah menggunakan standar Surat Edaran Menteri PUPR No.8/SE/M/2010 tentang Pemberlakukan Pedoman Penilaian Kerusakan Pantai dan Prioritas Penanganannya.
Hasil penelitian menunjukkan bahwa analisa penilaian kerusakan pantai dan penentuan prioritasnya berdasarkan kerusakan lingkungan dan tingkat kepentingannya pada lokasi Desa Hatu masuk kategori prioritas E (tidak diutamakan), untuk kerusakan akibat erosi/abrasi dan kerusakan bangunan pantai Desa Hatu, temasuk kategori kurang diutamakan (prioritas D), sampai dengan amat sangat diutamakan – darurat (prioritas A), yaitu pada kerusakan tembok laut sepajang 55 m, di antara STA 0+100 s/d 0+200 akibat gerusan gelombang.
Kata kunci: Desa Hatu, Kerusakan Pantai, Pulau Ambon.
Pengaruh Profitabilitas, Solvabilitas, Auditor Switching, dan Ukuran Perusahaan Terhadap Penyelesaian Audit (Audit Delay) (Studi Empiris Pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Periode 2017-2021)
Authors: Amalia Rizki , Indupurnahayu Indupurnahayu 
Published: February 2024

This study aims to determine the effect of profitability, solvability, auditors switching, and company size in manufacturing companies in the various industrial sectors listed on the Indonesia Stock Exchange (IDX) for the 2017-2021 period. The research method used in this study is a quantitative approach using a descriptive method in which the results of research data are in the form of presentation of statistical results obtained using Eviews 12 software. This research uses secondary data. Sampling using technique purposive sampling and there are 21 manufacturing companies in various industrial sectors with a five-year period.
Based on the analysis that has been carried out in this study, the results show that the influence of the profitability and solvability variables is a significant negative effect on audit delay, then the auditor switching variable has a significant positive effect and firm size does not have a significant effect on audit delay. Thus, companies that have good profitability and solvability will reduce audit delay because management will speed up the publication of financial reports. Then the change of auditors will extend the audit delay because the new auditor must adapt again to company conditions, and the size of a company size must pay attention to audit delay because it will attract investors, and avoid sanctions.
Maleficient’s horn like appearance myxomatous fusiform aneurysm of the right middle cerebral artery: An evil caused by the atrial myxoma.
Authors: Khoirul Hadi  
Published: February 2024

Atrial myxoma is the most common neoplasm of the heart which consist of 50% of the total cases reported and tend to seed peripherally after operation(1). When the dissemination occurred in the brain, patient normally presented with stroke symptoms due to tumour embolism. However, cerebral aneurysm due to metastatic deposit after atrial myxoma incision is rare.
In a study by M. Anvari et al showed that the most common presentation of atrial myxoma is shortness of breath (63%), followed by chest pain (37%) and neurological symptoms, which is mostly related to stroke (26%)(2). In some cases, patient presented with constitutional symptoms like loss of weigh and appetite and some with anaemic symptoms(2). Size of the lesion mainly related to the local symptoms due obstruction of the blood flow in the heart, but the rate of dissemination is depending on the mobility of the lesion(3). Histologically, mayo clinic has divided the tumour based on its gross anatomy into solid and papillary type. The solid type is normally larger and causing obstructive symptoms, however papillary type is the one that tends to embolise peripherally(4).
Atrial myxoma can be diagnosed by echocardiogram and mostly located within the left atrium, specifically within the fossa ovalis in 75% of the cases (3). In some cases, MRI is needed to confirm the diagnosis because sometimes thrombus, vegetation or primary lymphoma of the heart might mimic the tumour. In a case of brain dissemination, the stroke due to embolization can be detected via plain CT brain as it will show multifocal infarction predominantly at the cortimedullary junction which is not specific to the arterial territory. As the dissemination occurred at the vessel wall, it can lead to aneurysm formation which can be detected by plain CT brain and confirmed by MRI or cerebral angiogram. We are reporting a case of multiple fusiform cerebral aneurysm 9 years after left atrial myxoma operation.
Investigating the Impact of Productivity on Surface Roughness and Dimensional Accuracy in FDM 3D Printing
Authors: Kónya Gábor 
Published: February 2024

Over the past three decades, 3D printing technologies have undergone significant advancements, revolutionizing various industries, such as automotive. Additive manufacturing has played a crucial role in reducing product development time and enabling the direct printing of functional parts. One of the key advantages of additive manufacturing is its ability to provide greater design freedom compared to traditional manufacturing methods. This means that complex geometries and varying material properties can be easily printed. In this research paper, the author focused on investigating the impact of layer thickness and part orientation on the surface roughness and accuracy of printed parts. The main objective was to identify the optimal combination of layer thickness and part orientation that would yield the best results in terms of surface roughness and accuracy, considering printing time as a variable. The results from printing time, accuracy and surface roughness measurements showed that the vertical orientation is the superior for cylindrical orientation.
واقع توافر الإمكانيات المادية والبشرية لإنجاح المخيمات الكشفية المدرسية من وجهة نظر اصحاب القرار
Authors: Teacher .Dr. Haider Abdul Hussein Jassim  
Published: February 2024

هدف البحث الى اعداد استبانة خاصة لتوافر الامكانيات المادية والبشرية من وجهة نظر القادة الكشفيين في العراق . والتعرف على مدى توافر الامكانيات المادية والبشرية لإدارة المخيمات الكشفية المدرسية من وجهة نظر القادة الكشفيين في العراق . قام الباحث بتحديد مجتمع بحثة من اصحاب القرار في العراق مديرية والنشاط الرياضي والكشفي في العراق حيث بلغ مجتمع البحث الحالي (378) من اصحاب القرار وتشكل نسبة 100% منهم والموزعين في مديريات والنشاط الرياضي والكشفي في العراق حيث اقتصر الباحث على وزارة التربية لكون العينة قريبة من الباحث اعتمد الباحث النسبة المئوية ( 50%) من مجتمع البحث الحالي بإخذ هذه النسبة بصورة عشوائية حيث بلغت عينة البحث الحالي (189) من اصحاب القرار وقد تم الاعتماد على الطريقة العشوائية البسيطة (القرعة) في اختيار العينة ومن ثم تم تقسيم عينة البحث الحالية البالغة (189) الى (3) عينات ( استطلاعية – ثبات – تطبيق ) وابرز التوصيات ضرورة غرس الاخلاق والقيم التنظيمية لدى الطلبة من اجل فهم اهداف المخيمات الكشفية المدرسية بشكل صحيح من قبل الطلبة . ضرورة ان تكون الاهداف الموضوعة من قبل القائمين على ادارة المخيم الكشفي ان تكون واقعية ومفهومة بشكل صحيح .ضرورة ان يمتلك القائمين على ادارة المخيمات الكشفية يمتلكون رؤية مستقبلية واضحة عن تحقيق الاهداف للمخيم الكشفي .
Development of a mini pig model of peanut allergy
Authors: Shakya Akhilesh Kumar , Backus Brittany , Nesovic Lazar D. , Mallick Malini , Banister Olivia , Davis Carla M. , Anvari Sara , Gill Harvinder Singh 
Published: February 2024

IntroductionThe prevalence of peanut allergies is increasing, emphasizing the need for an animal model to enhance our understanding of peanut allergy pathogenesis and to advance diagnostic tools and therapeutic interventions. While mice are frequently used as model organisms, their allergic responses do not fully mirror those observed in humans, warranting the exploration of a higher animal model. The porcine gastrointestinal system closely resembles that of humans, and exhibits allergy symptoms akin to human responses, making pigs a promising model for peanut allergy research.MethodsIn this study we compared two allergen sensitization protocols involving either topical allergen application after repeated tape stripping (TS) or intraperitoneal (IP) injections to induce peanut-specific allergy and anaphylaxis reactions in mini pigs. Mini pigs sensitized with a combination of peanut protein extract (PE) and cholera toxin (CT) through either the IP or the TS route.ResultsSensitized pigs via both methods developed systemic PE-specific IgG and IgE responses. Following peanut challenge via the IP route, both TS- and IP-sensitized pigs displayed allergy symptoms, including lethargy, skin rashes, vomiting, and a drop in body temperature. However, respiratory distress was observed exclusively in pigs sensitized through the TS route and not in those sensitized through the IP route. However, it is noteworthy that both groups of sensitized pigs maintained peanut hypersensitivity for up to two months post-sensitization, albeit with a reduction in the severity of allergy symptoms. Importantly, both groups exhibited sustained levels of PE-specific IgG, IgE, and elevated concentrations of mast cell protease in their blood following the IP challenges.DiscussionOverall, this study reports TS and IP as two different modes of sensitization leading to onset of peanut specific allergic reactions in mini pigs, but only the TS-sensitization led to systemic anaphylaxis (simultaneous presence of symptoms: breathing difficulty, intense skin rash, and impaired mobility). A distinctive feature of these sensitization protocols is the 100% success rate (N = 4 pigs per group) in sensitizing the subjects.
Grasping knowledge, attitude, and perception towards monkeypox among healthcare workers and medical students: an Egyptian cross-sectional study
Authors: Amer Fatma A. , Nofal Hanaa A. , Gebriel Manar G. , Bedawy Aya M. , Allam Ayman A. , Khalil Hend E. S. , Elahmady Mohammed , Nofal Hagar , Saeed Maysaa A. , Shaltout Shaker Wagih , Behiry Ahmed , Attia Osama , Bahgat Shereen Mohamed , Ali Ahmed A. , Ahmed Fatma Mohammed , Abdelrahman Ahmed Mohammed , Hammad Noha M. 
Published: February 2024

BackgroundMonkeypox (Mpox) is a re-emerging infectious disease representing a new global challenge. It poses a substantial threat to countries, particularly those with a low number of cases. Due to its popularity as a tourist destination and its proximity to many African refugees, Egypt is potentially at risk of Mpox importation. Therefore, effective disease management necessitates healthcare workers (HCWs) to possess adept knowledge, along with a positive attitude and behavior. The study aimed to assess the knowledge, attitude, and perception of Egyptian HCWs and medical students towards human Mpox.MethodsThe present cross-sectional study data was collected from participants between October and December 2022 via a questionnaire. The questionnaire comprised 31 questions in the knowledge section, 11 questions in the attitude section, and 14 in the perception section.ResultsThe present study involved a total of 1,034 HCWs and medical students. It was found that 55.3% of the participants demonstrated adequate knowledge about Mpox, whereas 44.5% and 39.8% of the respondents exhibited favorable attitudes and perceptions towards the disease, respectively. Binary logistic regression analysis revealed that adequate knowledge was significantly observed in ages older than 40 years (p &lt; 0.001), married participants (p &lt; 0.001), and doctors (p &lt; 0.001). The positive attitude was significantly observed among the male sex (p = 0.045), urban residents (p = 0.002), and nurses (p = 0.002). Conversely, married participants (p = 0.013), doctors (p &lt; 0.001), and individuals employed in pharmacy and laboratory departments (p &lt; 0.001) experienced an increase in positive perception.ConclusionKnowledge, attitude, and perception towards Mpox among Egyptian HCWs and medical students exhibit suboptimal levels. Addressing these gaps is crucial to controlling and effectively preventing disease transmission.
Electronic medical record systems data use in decision-making and associated factors among health managers at public primary health facilities, Dodoma region: a cross-sectional analytical study
Authors: Kessy Eusebi Cornelius , Kibusi Stephen Mathew , Ntwenya Julius Edward 
Published: February 2024

BackgroundTanzania has shown some improvements in the adoption of electronic medical record (EMR) systems in public health facilities; however, the rate of utilization of data generated from EMRs among health managers is not well documented. This study aims to assess the use of electronic medical record systems data in decision-making among health managers at public primary health facilities in Dodoma Region, Central Tanzania.MethodsA facility-based quantitative cross-sectional analytical study was conducted among 308 randomly selected health managers. A self-administered questionnaire supplemented with documentary review was used. Descriptive summary statistics and bivariable and multivariable logistic regression analyses (crude and adjusted odds ratios) were used. A P-value of &lt;0.05 was used to declare statistically significant associations.ResultsOverall, more than a third (40.6%) of the health managers, that is 174 of the 308 included in the study, reported using data generated by EMR systems in decision-making. One-third (33.4%) of the health managers were adequately using data generated by EMR systems, of which 39.3% used data to support continuous quality improvement initiatives. Among the facilities visited, only nine (30%) had good documented EMR systems data use. Access to computers [adjusted odds ratio (AOR) = 4.72, 95% confidence interval (CI): 1.65, 13.48, p-value (p) = 0.004] and discussions on EMRs during meetings (AOR = 2.77, 95% CI: 1.01, 7.58, p = 0.047) were independent predictors of EMR system data use. Those who reported having EMR systems in all working areas were seven times more likely to use EMR system data (AOR = 7.23, 95% CI: 3.15, 16.59, p = 0.001). The respondents with good perceived EMR system information quality were more likely to use EMR system data (AOR = 2.84, 95% CI: 1.50, 5.39, p = 0.001) than those with poor perception. Furthermore, health managers who had excellent knowledge of computers and data use had higher odds of using EMR system data (AOR = 1.84, 95% CI: 3.38, 10.13, p = 0.001) compared with their counterparts.ConclusionsThe findings of this study indicate that utilization of EMR system data in decision-making among health managers was optimal. It was found that training in itself is insufficient to improve use of EMR, which points to more organizational aspects of work routine as a challenge. Hence, a comprehensive approach that addresses these factors is essential for maximizing EMR system data use in decision-making.
Expression and localization of HPG axis-related genes in Carassius auratus with different ploidy
Authors: Xu Xiaowei , Yang Li , Deng Xinyi , Xiao Qingwen , Huang Xu , Wang Chongqing , Zhou Yue , Luo Xiang , Zhang Yuxin , Xu Xidan , Qin Qinbo , Liu Shaojun 
Published: February 2024

IntroductionIn the Dongting water system, the Carassius auratus (Crucian carp) complex is characterized by the coexistence of diploid forms (2n=100, 2nCC) and polyploidy forms. The diploid (2nCC) and triploid C.auratus (3n=150, 3nCC) had the same fertility levels, reaching sexual maturity at one year. MethodsThe nucleotide sequence, gene expression, methylation, and immunofluorescence of the gonadotropin releasing hormone 2(Gnrh2), Gonadotropin hormone beta(Gthβ), and Gonadotropin-releasing hormone receptor(Gthr) genes pivotal genes of the hypothalamic-pituitary-gonadal (HPG) axis were analyzed. ResultsThe analysis results indicated that Gnrh2, follicle-stimulating hormone receptor(Fshr), and Lethal hybrid rescue(Lhr) genes increased the copy number and distinct structural differentiation in 3nCC compared to that in 2nCC. The transcript levels of HPG axis genes in 3nCC were higher than 2nCC (P&lt;0.05), which could promote the production and secretion of sex steroid hormones conducive to the gonadal development of 3nCC. Meanwhile, the DNA methylation levels in the promoter regions of the HPG axis genes were lower in 3nCC than in 2nCC. These results suggested that methylation of the promoter region had a potential regulatory effect on gene expression after triploidization. Immunofluorescence showed that the localization of the Fshβ, Lhβ, and Fshr genes between 3nCC and 2nCC remained unchanged, ensuring the normal expression of these genes at the corresponding sites after triploidization. DiscussionRelevant research results provide cell and molecular biology evidence for normal reproductive activities such as gonad development and gamete maturation in triploid C. auratus, and contribute to further understanding of the genetic basis for fertility restoration in triploid C. auratus.
Novel FOXL2 variants in two Chinese families with blepharophimosis, ptosis, and epicanthus inversus syndrome
Authors: Zhao Mingyu , Meng Xiaolu , Wang Jiaqi , Wang Tailing 
Published: February 2024

Introduction: Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) is a rare inherited disorder. This study was aimed to identify and functionally validate FOXL2 variants in two Chinese families with BPES.Methods: The proband and his family members were subjected to whole-exome sequencing to identify disease-associated variants. Several bioinformatic tools were used to computationally predict altered proteins. In vitro functional assays were conducted by transfecting wild-type and mutant FOXL2 cDNAs into HEK-293 cells, followed by subcellular localization assays, luciferase reporter gene assays, and quantitative real-time polymerase chain reaction.Results: The clinical features of BPES, including small palpebral fissures, ptosis, telecanthus, and epicanthus inversus, were present in all affected patients. Two novel mutations were detected, c.292T&gt;A and c.383G&gt;T. Whole-exome sequencing analysis and prediction software suggested that these mutations were pathogenic. Functional studies showed that these two point mutations decreased FOXL2 protein expression, resulting in subcellular mislocalization and aberrant transcriptional activity of the steroidogenic acute regulatory protein gene promoter.Conclusion: Our results add to the current understanding of known FOXL2 variants in, and our in vitro experiments provide reference data and insights into the etiology of BPES. Further studies are needed to identify the possible mechanisms underlying the action of this mutation on the development of BPES.
Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease
Authors: Fernández-Soto Daniel , García-Jiménez Álvaro F. , Casasnovas José M. , Valés-Gómez Mar , Reyburn Hugh T. 
Published: February 2024

IntroductionIt is now clear that coronavirus disease 19 (COVID-19) severity is associated with a dysregulated immune response, but the relative contributions of different immune cells is still not fully understood. SARS CoV-2 infection triggers marked changes in NK cell populations, but there are contradictory reports as to whether these effector lymphocytes play a protective or pathogenic role in immunity to SARS-CoV-2.MethodsTo address this question we have analysed differences in the phenotype and function of NK cells in SARS-CoV-2 infected individuals who developed either very mild, or life-threatening COVID-19 disease.ResultsAlthough NK cells from patients with severe disease appeared more activated and the frequency of adaptive NK cells was increased, they were less potent mediators of ADCC than NK cells from patients with mild disease. Further analysis of peripheral blood NK cells in these patients revealed that a population of NK cells that had lost expression of the activating receptor NKG2D were a feature of patients with severe disease and this correlated with elevated levels of cell free NKG2D ligands, especially ULBP2 and ULBP3 in the plasma of critically ill patients. In vitro, culture in NKG2DL containing patient sera reduced the ADCC function of healthy donor NK cells and this could be blocked by NKG2DL-specific antibodies.DiscussionThese observations of reduced NK function in severe disease are consistent with the hypothesis that defects in immune surveillance by NK cells permit higher levels of viral replication, rather than that aberrant NK cell function contributes to immune system dysregulation and immunopathogenicity.