bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor abnormal protein as a promising biomarker for screening solid malignancies and monitoring recurrence and metastasis
Authors: Zhang Zhihui , Tian Changjun , Liu Yuexuan , Zhang Lin , Sun Han , He Siqi , Liu Yujia , Fan Hui , Zhang Yongsheng , Gao Mingxin , Wu Shuhua 
Published: December 2023

BackgroundTumor abnormal protein (TAP), the sugar chain protein released by tumor cells during metabolism, allows the development of a technique that exploits aggregated tumor-associated abnormal sugar chain signals in diagnosing malignancies. Clinically, we have found that TAP detection can well predict some malignancies, but several physicians have not paid attention, and related studies have been minimal.MethodsWe evaluated TAP’s ability to distinguish between malignancies and benign diseases by receiver operating characteristic (ROC) curve analysis and studied the possibility of monitoring malignancy progression by evaluating TAP levels in follow-up. We used Kaplan-Meier survival curves and Cox proportional hazard regression models to investigate the relationship between TAP and prognosis.ResultsTAP levels were higher in whole solid malignancies and every type of solid malignancy than in benign patients. ROC curve analysis showed that TAP levels aid in distinguishing between malignancies and benign diseases. TAP levels decreased in patients with complete remission (CR) after treatment and increased in patients with relapse from CR. Patients with metastases had higher TAP levels than non-CR patients without metastases. There was no difference in overall survival among patients with different TAP levels, and multivariate analysis suggested that TAP was not an independent risk factor for solid malignancies.ConclusionTAP is an effective screening biomarker for many solid malignancies that can be used to monitor the progression of malignancies but not to prognosticate.
Analysis of anti-rheumatic activity of Nyctanthes arbor-tristis via in vivo and pharmacovigilance approaches
Authors: Sharma Ayushi , Goel Anjana , Lin Zhijian 
Published: December 2023

Introduction: Rheumatoid arthritis (RA) is an immune-mediated disease associated with chronic inflammation of numerous joints. Nyctanthes arbor-tristis (NAT) is a traditional remedy for RA, a chronic inflammatory disorder.Aim: The current project aims to demonstrate the role of the NAT extracts in sub-acute toxicity, pharmacovigilance, and anti-rheumatic biomarkers.Method: Hydroethanolic extract (1:1) of plant leaves was prepared by using the reflux method. The safety of the dose was evaluated in Sprague–Dawley rats, and the anti-inflammatory effects of NAT on RA symptoms, including paw volumes, body weight, arthritic index, withdrawal latency, hematology and serological test, radiology, and histopathology, were evaluated in Freund’s complete adjuvant (FCA)-induced arthritis Sprague–Dawley rat models. The inflammatory (TNF-α and COX-2) and anti-inflammatory markers (IL-10) were analyzed in control and experimental groups.Result: The study showed that 500 mg/kg BW NAT leaf extract was found to be least toxic without showing any subacute toxicity symptoms. The pharmacovigilance study highlighted the potential side effects of NAT, such as drowsiness, sedation, and lethargy, at high dosages. Treatment with the plant extract mitigated paw edema, restored the immune organ and body weights, and ameliorated the level of blood parameters such as hemoglobin, red blood cells, platelets, white blood cells, aspartate aminotransferase (AST), alanine transaminase (ALT), C-reactive proteins, and rheumatoid factor. Treatment with the plant extracts also reduced the level of cyclooxygenase 2 and TNF-α and increased the level of IL-10 in the serum of arthritic rats dose-dependently. Radiographic analysis of the ankle joint showed an improvement in the hind legs. Histological examination of the ankle joints revealed that the plant extract treatment decreased pannus formation, inflammation, and synovial hyperplasia in arthritic animals.Conclusion: NAT 500 mg/kg could serve as a promising therapeutic option for the treatment of inflammatory arthritis.
Electromyography of scapular stabilizers in people without scapular dyskinesis during push-ups: a systematic review and meta-analysis
Authors: Arghadeh Ramin , Alizadeh Mohammad Hossein , Minoonejad Hooman , Sheikhhoseini Rahman , Asgari Mojtaba , Jaitner Thomas 
Published: December 2023

Background: Push-up (PU) is widely considered an effective exercise to stabilize the scapular, especially if performed on unstable surfaces. However, available studies cover a wide range of exercise variations and differ according to exercise prescription, muscle selection and study design. Therefore, findings are contradictory, and conclusions for a proper application of the PU are difficult to draw.Objective: To synthesize the available literature on the changes in the activity of the periscapular muscles in individuals without scapular dyskinesis while performing different types of PU on unstable surfaces.Search procedure: Four online databases were searched from the earliest publications to 9 August 2023, using predefined keywords. Out of the 2,850 potential references identified in the primary search, 92 studies were reviewed in detail, of which 38 met the inclusion criteria and were included. Methodological quality was evaluated using a standardized form based on the Newcastle‒Ottawa scale for observational studies. Data combination was performed using CMA (v3), and the random-effects model was used to calculate the standardized mean difference (SMD) with a 95% confidence interval (CI).Results: The use of unstable surfaces in people without scapular dyskinesis led to increased activity of the upper trapezius during the PU (p = 0.017; I2 = 84.95%; SMD = 0.425 [95% CI 0.077, 0.773]) and knee PU (p = 0.023; I2 = 70.23%; SMD = 0.474 [95% CI 0.066, 0.882]) exercises and increased activity of the middle trapezius (MT) (p = 0.003; I2 = 64.50%; SMD = 0.672 [95% CI 0.225, 1.119]) and serratus anterior (SA) (p = 0.039; I2 = 4.25%; SMD = 0.216 [95% CI 0.011, 0.420]) muscles during the push-up plus (PUP) exercise.Conclusion: Using an unstable support base during PU does not necessarily increase the activity of all scapular stabilizers. The amount of muscle activity depends on the type of PU other than the type of support base. If an unstable surface is used, PUP exercise appears to be the most effective modality to increase the quality of training, improve performance, and prevent the occurrence of scapular dyskinesis due to the increase in the activity of the MT and SA muscles.Systematic Review Registration: http://www.crd.york.ac.uk/PROSPERO, CRD42021268465.
Effects of probiotics on neurocognitive outcomes in infants and young children: a meta-analysis
Authors: Lin Feng-Li , Chen Chia-Min , Sun Cheuk-Kwan , Cheng Yu-Shian , Tzang Ruu-Fen , Chiu Hsien-Jane , Wang Ming-Yu , Cheng Ying-Chih , Hung Kuo-Chuan 
Published: December 2023

BackgroundTherapeutic efficacies of probiotics in improving neurocognitive functions in infants and young children remained unclear. This meta-analysis focused on different cognitive outcomes in this population.MethodsMajor databases were searched electronically from inception to October 2023 to identify randomized controlled trials (RCTs) that investigated the therapeutic efficacy of probiotics in enhancing cognitive functions assessed by standardized tasks. The overall effect size was calculated as standardized mean difference (SMD) based on a random effects model.ResultsNine RCTs with 3,026 participants were identified. Both our primary and secondary results demonstrated no significant difference in neurocognitive outcomes between infants/children treated with probiotics and those receiving placebos. However, our subgroup analysis of studies that offered a probiotics treatment course of over six months demonstrated a significantly better neurocognitive outcome than placebos (SMD = 0.21, p = 0.03, two studies with 451 participants), but this finding was based on only two RCTs.ConclusionDespite lack of significant therapeutic effects of probiotics on neurocognitive outcomes, our finding of a positive impact of probiotics on neurocognitive development in those undergoing treatment for over six months may provide an important direction for further investigations into the enhancement of therapeutic effects of probiotics on neurocognitive development in infants and young children.Systematic review registrationPROSPERO CRD42023463412.
ANALISA HADIST TAJDID DIN
Authors: Muhibuddin Muhibuddin , Saefullah Awwab 
Published: December 2023

Konsekuensi syahadat adalah iman kepada Rasulullah saw., dan bukti keimanan itu ditunjukkan dalam bentuk sikap. Rasulullah juga menegaskan bahwa Allah Swt. memberikan anugerah-Nya dengan memunculkan para mujadid (pembaharu) yang mengikuti jejak Rasulullah saw. untuk menghidupkan kembali ajaran Islam yang murni. Hadis tajdid adalah hadis yang memiliki kualitas derajat hadis shahih jika dilihat dari sanad (jalur periwayatannya). Dari segi matan maka hadis ini tidak memiliki cacat karena sesuai dengan AlQuran dan hadis shahih lainnya. Hadis ini juga merupakan salah satu bukti kenabian Rasulullah, karena terkait dengan kabar masa depan (nubuat). Serta hadis ini merupakan kabar gembira bagi umat Islam sekaligus bukti penjagaan dari Allah Swt. atas agama ini (Islam). Adapun penelitian ini menggunakan metode penelitian kualitatif yang dipadukan dengan kajian pustaka. Teknik pengumpulan data peneliti mengamati data sesuai dengan pembahasan. Informasi diperoleh dari berbagai buku, literatur, dokumen, majalah, publikasi, artikel dan informasi dari media cetak dan elektronik lainnya yang berkaitan dengan masalah yang teridentifikasi. Dari hasil penelitian ini maka disimpulkan bahwa: 1) Makna tajdid menurut jumhur ulama (konservatif) adalah upaya pembaharuan (mengembalikan) Islam menuju Al-Quran dan Sunah seperti masa pemahaman di masa Rasulullah dan Khulafa Rasyidin, 2) Makna tajdid yang diarahkan kepada modernisasi (oleh kaum modernis) justru seolah makin menjauhkan dari pemahaman generasi terbaik (salafu salih) terhadap Al-Quran dan Sunah.
PERAN GURU PENDIDIKAN AGAMA KATOLIK DALAM MENEGAKKAN DISIPLIN SISWA KELAS VII SMP RK DELI MURNI DELITUA
Authors: Tibo Paulinus , Br Munthe Yelly Yuwindawati 
Published: December 2023

This research was conducted to determine the role of Catholic religious education teachers in enforcing the discipline of class VII students at SMP RK Deli Murni Delitua. This study uses a qualitative method. The qualitative method was chosen because it can explore a problem in depth and can explain in detail problem that occurs, starting from identifying a problem to explaining the solution. This study used several techniques o collect the data namely interviews, observation, and documentation. The research subject used were 1 tutor, 1 school principal, 1 colleague, and 6 students of class VII junior high school. The results of this study indicate that there are still students who do not obey the rules set by the school,students who skip school, students who come late to school, and student who smoke at school. Researchers found that the role of Catholic religious education teachers in upholding student discipline was good. Learning the Catholic religion implies that discipline is the main requirement to obey the rules. The contribution to the school is with the role of the Catholic religious education teacher as a good educator.
Squalius seyhanensis (Teleostei: Leuciscidae)'nin Dağılımına İlişkin Yeni Veriler
Authors: BAYÇELEBİ Esra 
Published: December 2023

Squalius seyhanensis türü Akdeniz Havzasında Bulunan Seyhan Nehri’nin drenajı olan Sarız
deresinden tanımlanmıştır, Türün dağılım alanı Seyhan Nehri ve Fırat Nehri'nin batı havzasıdır.
Bu çalışmada türün bilinen dağılım alanlanın yanı sıra Kızılırmak Nehri'nin drenajı olan Kışla
deresinden de kaydı verilmiştir. Bu çalışmada Kışla ve Sarız popülasyonlarını karşılaştırılmıştır.
Ayırt edici karakterler olan vücut yüksekliği (24.9-27.4% SB, vd. 24.8-28.1) ve kuyruk sapı
yüksekliği (11.8-13.3% SB, vd. 11.8-13.3) neredeyse tamamen örtüşmektedir.
La preuve : armature de toute responsabilité
Authors: Safa Nour 
Published: December 2023

Solution - Si l’existence d’un lien de causalité entre l’inexécution d’une obligation par une partie à un contrat et le préjudice subi par l’autre partie est une condition primordiale pour engager la responsabilité contractuelle de la première et par suite l’obtention par la seconde des dommages et intérêts, la preuve de ce lien n’est pas toujours aussi évidente qu’elle ne le paraît. C’est dans ce sens que l’analyse de la décision rendue le 15 mars 2022 sous le numéro 20/02307 par la deuxième chambre civile de la Cour d’appel de Grenoble s’avère intéressante.
Quand les présomptions de fait permettent de retenir le recel au détriment du vol en l’absence de preuve matérielle d’acte de soustraction
Authors: Hamonic Julie 
Published: December 2023

La Cour d’appel de Grenoble prononce la condamnation du prévenu pour recel, alors que les faits de l’espèce laissent peu de doute sur le fait que le prévenu est également l’auteur du vol. Sur la base des éléments de preuve concordants produits par la victime et des déclarations contradictoires du prévenu, les juges du fond ont retenu que ce dernier avait « nécessairement connaissance du caractère frauduleux des objets volés » retrouvés en sa possession.
Garanties de réinsertion et aménagement des courtes peines d’emprisonnement avant mise à exécution
Authors: Royer de Véricourt Camille , Fournier Sous la dir. de Stéphanie , Robert Sous la dir. d'Anne-Gaëlle 
Published: December 2023

Alors que depuis la loi de programmation pour la justice du 23 mars 2019, le juge correctionnel ne doit plus prendre en compte les garanties de réinsertion pour aménager ab initio les courtes peines d’emprisonnement, les juridictions de l’application des peines semblent au contraire continuer de l’exiger lorsqu’elles se prononcent dans le cadre de l’article 723-15 du Code de procédure pénale.
Enrichissement injustifié et financement du logement de la concubine
Authors: Ruffieux Gaëlle 
Published: December 2023

Les relations familiales en général et le concubinage en particulier constituent le terreau idéal de l’enrichissement injustifié. Le concubin trop généreux ayant participé au financement du logement du couple appartenant exclusivement à sa concubine peut-il obtenir le remboursement des sommes exposées sur le fondement de l’action de in rem verso  ? L’arrêt rendu par la Cour d’appel de Grenoble le 1er février 2022 s’inscrit dans un courant jurisprudentiel en vertu duquel les outils du droit commun, régulièrement sollicités par les justiciables, sont de moins en moins mobilisés par les juges pour régler les intérêts patrimoniaux des concubins qui se séparent.
Recovery of cycling-induced degradation of interfacial SiO2 in HfO2-FeFET and its impact on retention characteristics
Authors: Schlykow Viktoria , Suzuki Kunifumi , Yoshimura Yoko , Hamai Takamasa , Sakuma Kiwamu , Matsuo Kazuhiro , Suzuki Masamichi , Saitoh Masumi , Ichihara Reika 
Published: December 2023

Abstract
A detailed understanding of cycling induced degradation of interfacial SiO2 in HfO2-FeFET devices is presented. By direct observation of electron trapping to cycling-generated trap sites in various time domains, we found that trap sites disappear over time. This recovery of the degradation has a non-negligible impact on the retention characteristics after cycling.
Grid-patterned trench insulated gate bipolar transistor for 1.2 kV hybrid/plug-in hybrid electric vehicle silicon power devices
Authors: Machida Satoru , Yamashita Yusuke , Saito Jun , Senoo Masaru 
Published: December 2023

Abstract
This paper reports on the newly developed silicon insulated gate bipolar transistor (IGBT) for Toyota’s fifth generation power devices. The designed IGBTs with a grid-patterned trench provide a lower on-state voltage (V

ON
) while maintaining a wide mesa width. A successful 15% reduction of V

ON
was accomplished by enhancement of the two-dimensional hole storage effect. Furthermore, the grid-patterned trench IGBT merged with Schottky and multi-layered anode technology demonstrated a significant improvement in the trade-off curve between the reverse recovery current (I

rr
) and V

ON
in a reverse conducting IGBT without a lifetime control process. As a result, the grid-patterned trench IGBT has contributed to reduce power loss and volume in the new power control units.
EMIB and advanced substrate packaging technologies to enable heterogeneous integration (HI) applications
Authors: Duan Gang , Mahajan Ravi , Manepalli Rahul , Azimi Hamid 
Published: December 2023

Abstract
Heterogeneous chiplet integration has become a crucial performance enabler in the microelectronics industry by providing the flexibility of die disaggregation, and the ability to mix/match different IP blocks optimized on different Si nodes in a single package. It shows great potential in supercomputing, autonomous driving, artificial intelligence, and machine learning applications. With rising demand in high performance computing, the key focus in heterogeneous integration (HI) scaling has been to push interconnect density with increased bandwidth and improved power efficiency. In this paper, we provide an overview of embedded multi-interconnect bridge packaging technology scaling and discuss key considerations for advanced substrate packaging technologies to enable further HI applications.
Application of digital twin technology in Russia: Development opportunities and constraints
Authors: Sosfenov D. A. , Shahova M. S. 
Published: December 2023

Aim. To identify trends in the development of the digital twin concept in Russia.Objectives. To analyze the experience of applying such an innovative tool as a digital twin at Russian enterprises and consider the benefits of its implementation; to characterize the aspects of regulation and state support in the field of digital twin application in Russia; to reveal the main problems hindering the development of digital twin technology, as well as to propose posible solutions to the identified problems.Methods. The authors used empirical methods, in particular, the analysis and generalization of data from scientific and methodological literature; methods of observation and comparison. The article also reflects the results of scientific research of Russian and foreign scientists.Results. It is established that today the method of digital twins in the economy is becoming more and more popular. Thanks to the introduction of digital twin technology, companies manage to speed up production processes, increase their transparency, reduce costs, improve the quality of manufactured products and, in general, achieve greater efficiency, competitiveness and investment attractiveness. The main constraints to development include insufficient funds required to implement digital transformation, lack of necessary experience and highly qualified specialists, low level of legal framework in the field of digital twins and high level of risks associated with data security. For successful implementation of digital transformation, it is advisable to study and generalize successful examples of digital twins implementation both in foreign and domestic companies, to create a unified management system for this area, to develop a motivation system for companies applying digital twin technology, to increase the level of information security.Conclusions. In Russia, innovative technologies are a priority for ensuring technological leadership and entry of domestic companies into international markets. Despite lagging behind some foreign countries, Russia has great potential for the formation of a national market and the introduction of digital twin technology, especially among large corporations and high-tech enterprises. But for this purpose it is necessary to eliminate the factors that hinder the development of the digital twin method, such as high risks associated with cybersecurity, insufficient funding in the use of technology, the lack of specificity in some cases in the field of legal regulation and a number of others.
Transformation of management of dental organizations in the conditions of transition to a value-based healthcare model
Authors: Yashin S. N. , Avdeeva I. N. , Aleshina O. A. 
Published: December 2023

Aim. To develop recommendations for management consulting on practical implementation of the model of value-oriented approach in medical organizations of dental profile.Objectives. To analyze the experience of implementing the elements of the value-oriented approach in the management of dental organizations in foreign medical practice and dental institutions of the Russian health care system; to review foreign and domestic scientific literature in the context of the research topic; to study and apply the data of analytical reports of specialized international organizations.Methods. The authors used general scientific and special scientific methods. The analysis of domestic and foreign scientific publications in the context of the research topic was presented, and also methods of modeling, applied qualitative content analysis of information were applied.Results. The article investigates the models of implementation of the value-based approach in the organizations of the health care system abroad. The dissemination of the elements of this model in domestic dental institutions was analyzed. The conclusions about the main obstacles in the implementation of the principles of value-oriented approach in Russian dentistry are made. Recommendations on forms and methods of management consulting for effective implementation of the value-oriented health care model in the stomatological sphere of medical activity are formulated.Conclusions. According to the evaluations of pilot projects and indicators of scientific calculations, the transition to the system of value-oriented health care is slow, but it is recognized as an inevitable and necessary vector of health care development. Taking into account the socially useful effect of this model, the need for the Russian system of state guarantees of health care in the introduction of a value-oriented approach is extremely high. Further practical, research activities are necessary to develop tools for implementing the principles of value-oriented approach in the dental sphere.
Firenze 1865-1871: una capitale provvisoria
Authors: Paloscia Raffaele 
Published: December 2023

Il contributo fa parte degli Atti "1871: Firenze capitale...dell'Antropologia Italiana", redatti a seguito della giornata di celebrazioni dei 150 anni dalla fondazione della Società Italiana di Antropologia e Etnologia - Firenze, 15 Febbraio 2022