bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower Completions Design and Execution in the Complex ERD Well on Tengiz Oil Field
Authors: Rakhmetov Z. , Ismukhambetov A. , Sissenov O. , Click C. , Morrison A. , Takhanov D. , Simancas R. Gomez , Gabdulov T. , Kabiyev K. 
Published: December 2023

Abstract
This paper presents a case study of designing a lower completion deployment concept consisting of conformance control liner with up to 25 compartments (packers and sliding sleeves). The horizontal well was planned with the longest lateral section of up to 2,500m in an out-board area of Tengiz field. The reservoir in this area is known to have a modest carbonate matrix reservoir, relatively poorly connected with presence of scattered natural fractures networks. To maximize number of natural fracture intersections and contact with reservoir matrix, Tengizchevroil (TCO) planned to drill a horizontal well with long lateral section, followed by frac and/or matrix stimulation to improve production by connecting to the natural fracture network.
One of the main challenges of the well design was the ability to successfully deploy a lower completion to the well total depth (TD). Extended length of the lateral section causes drag accumulation along the string during the run which could lead to inability to run the liner to the desired depth. Generation of excessive compressional loads which could result in liner string buckling and ultimately to lock up was expected at open hole friction factors more than 0.45. Based on friction factors calibration from the other Tengiz offset wells with similar well trajectories which revealed 0.35–0.45 OH FF along with the absence of experience in running long completions strings with up to 25 compartments and lack of good understanding of OH FF in naturally fractured horizontal well, the decision was made to deliberately plan for 0.60 OH FF as design friction factor to establish feasibility.
Installation of the liner in this well at higher OH FF required consideration of advanced methods such as a) liner flotation, b) liner rotation, c) running a casing swivel. The detailed analysis of each of the methods revealed that introduction of liner rotation would not only solve the liner running issue on this well with long lateral section but may also allow completion of more extended lateral sections beyond 2,500m.
Multiple trait approach to inform ecosystem service value of corals propagated for restoration on the Great Barrier Reef
Authors: Lendo C. Isabel Nuñez , Camp Emma F. , Edmondson John , Hughes David J. , Kuzhiumparambil Unnikrishnan , Clases David , de Vega Raquel Gonzalez , Suggett David J. 
Published: December 2023

Abstract

Coral propagation- and planting-based reef restoration practices are accelerating globally, yet short-term “success” continues to be measured as broad metrics of coral survival and growth, even though goals are often centred on recovering broad ecosystem service values. As such, how restoration activities may impact healthy reef functioning remains uncertain. For example, trade-offs in resource acquisition and partitioning that potentially regulate growth vs survival may yield very different outcomes towards factors governing reef biogeochemical cycles. Here we considered a proof-of-concept “multi-trait” approach to capture how a broader range of functional traits reflect the expression of growth and survival for a key coral species (Acropora cf. hyacinthus) — impacted by recent mass bleaching events — propagated for restoration activities on the Great Barrier Reef (GBR), Australia. We examined a diverse array of bio-physical, bio-chemical, and skeletal traits (n = 91 traits) for wild (donor) colonies and their nursery-derived fragments from a 12-month growth period (Opal Reef, northern GBR). Nursery corals grew 20-25 times faster than their donor (wild) colonies, but both exhibited similar survivorship. Faster growth within nurseries was accompanied by more pigmented colonies (darker-coloured and with more symbionts), and higher photosynthesis, respiration, and calcification rates. However, despite these metabolic changes, biogeochemical properties of the nursery and reef corals (carbohydrates, lipids, proteins, elemental stoichiometry, and skeletal properties) remained largely the same after 12 months, suggesting the bio-energetic value to trophic transfer as well as the structural rigour of corals was unaltered by nursery propagation. Thus, a “multi-trait” approach enables more informed evaluation as to how propagation activities impact diverse ecosystem service values, highlighting the immense importance of this knowledge in choosing coral individuals for restoration. Our example provides confidence to practitioners that key ecosystem service attributes of native corals are largely retained through an intermediate nursery growth phase that can accelerate coral biomass gains.
The Effect Of Dexmedetomidine On The Perioperative Liver Function Of Diabetic Patients: Study Protocol For A Double-blinded 2 × 2 Factorial Randomized Controlled Trial.
Authors: Zeng Lin , Luo Tuo , Liu Yusong , Zeng Yali 
Published: December 2023

Abstract
Introduction Type 2 diabetes mellitus (T2DM) is one of the high-risk factors for gallbladder stones, and laparoscopic cholecystectomy (LC) is currently the common treatment for this disease. Oxidative stress (OS) and inflammatory response induced by intraoperative pneumoperitoneum may cause damage to liver function in patients with T2DM. Dexmedetomidine has sedative, analgesic, and anti-sympathetic effects. Several studies have reported that dexmedetomidine is a highly selective α2-adrenergic receptor agonist that protects liver function in perioperative patients by inhibiting OS and inflammatory response. However, patients with T2DM have not been included in the previous studies. The purpose of this study is to investigate the effects of perioperative low-dose dexmedetomidine on perioperative liver function in T2DM patients.
Methods and analysisThis is a double-blinded, randomized controlled trial using a 2×2 factorial trial design, which will be conducted from April 2022 to April 2024. Seventy-six patients undergoing elective LC will be included in this study, 38 with T2DM and 38 without diabetes, and they will be randomized into four groups (n=19 per group): nondiabetic dexmedetomidine group (ND group) and diabetic dexmedetomidine group (DD group) (intravenous pump injection with 4µg/ml dexmedetomidine) and nondiabetic control group (NC group) and diabetic control group (DC group) (intravenous pump injection with the same dose of normal saline). The main result is the activity of liver enzymes (AST, ALT, GGT). Secondary results include biomarkers of oxidative stress (ROS, MDA, SOD) and inflammatory response (TNF-α, IL-6).
Ethics and disseminationThis study was approved by the Ethics Committee of The First Affiliated Hospital of Chengdu Medical College (2020CYFYHEC-BA-64). The results of the trial will be presented at national and international meetings relevant to the topic area and submitted to international peer-reviewed journals.
Trial registration numberChiCTR2100049440. Registered April 9, 2022 https://www.chictr.org.cn/showproj.html?proj=131021
Sertraline for anxiety in adults with a diagnosis of autism (STRATA): Study protocol for a pragmatic, multicentre, double-blind, placebo-controlled randomised controlled trial.
Authors: Rai Dheeraj , Webb Doug , Lewis Amanda , Cotton Leonora , Norris Jade Eloise , Alexander Regi , Baldwin David S , Brugha Traolach S , Cochrane Madeleine , Piccolo Maria Chiara Del , Glasson Emma J , Hatch Katherine , Kessler David , Langdon Peter E , Leonard Helen , MacNeill Stephanie J , Mills Nicola , Morales Maximiliano Vazquez , Morgan Zoe , Mukherjee Raja , Realpe Alba X , Russell Ailsa , Starkstein Sergio , Taylor Jodi , Turner Nicholas , Thorn Joanna , Welch Jack , Wiles Nicola 
Published: December 2023

Abstract
Background: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to manage anxiety in adults with an autism diagnosis. However, their effectiveness and adverse effect profile in the autistic population is not well known. This trial aims to determine the effectiveness and cost-effectiveness of the SSRI sertraline in reducing symptoms of anxiety and improving quality of life in adults with a diagnosis of autism compared with placebo, and to quantify any adverse effects.
Methods: STRATA is a two parallel group, multi-centre, pragmatic, double blind, randomised placebo-controlled trial with allocation at the level of the individual. It will be delivered through recruiting sites with autism services in 4 regional centres in the United Kingdom (UK) and 1 in Australia. Adults with an autism diagnosis and a Generalised Anxiety Disorder Assessment (GAD-7) score ≥10 at screening will be randomised 1:1 to either 25mg sertraline or placebo, with subsequent flexible dose titration up to 200mg. The primary outcome is GAD-7 scores at 16-weeks post-randomisation. Secondary outcomes include adverse effects, proportionate change in GAD-7 scores including 50% reduction, social anxiety, obsessive compulsive symptoms, panic attacks, repetitive behaviours, meltdowns, depressive symptoms, composite depression and anxiety, functioning and disability, and quality of life. Carer burden will be assessed in a linked carer sub-study. Outcome data will be collected using online/paper methods via video call, face-to-face or telephone according to participant preference at 16, 24- and 52-weeks post-randomisation, with brief safety checks and data collection at 1-2, 4, 8, 12 and 36 weeks. An economic evaluation to study cost-effectiveness of sertraline vs placebo, and a QuinteT Recruitment Intervention (QRI) to optimise recruitment and informed consent are embedded within the trial. Qualitative interviews at various times during the study will explore experiences of participating and taking the trial medication.
Discussion: Results from this study should help autistic adults and their clinicians make evidence-based decisions on the use of sertraline for managing anxiety in this population.
Trial registration: ISRCTN, ISRCTN15984604. Registered 08 February 2021, https://www.isrctn.com/ISRCTN15984604. EudraCT: 2019-004312-66. ANZCTR,ACTRN12621000801819. Registered 07 April 2021.
Observation of mammalian living cells with femtosecond single pulse illumination generated by a soft X-ray free electron laser
Authors: Egawa Satoru , Sakurai Kai , Takeo Yoko , Yoshinaga Kyota , Takei Masashi , Owada Shigeki , Yamaguchi Gota , Yokomae Shunya , Mimura Hidekazu , Yamagata Yutaka , Yabashi Makina , Shimura Mari , Kimura Takashi 
Published: December 2023

Abstract

Soft X-ray transmission microscopy is a powerful tool for visualizing cellular structures due to the natural contrast between organic material and water, but radiation damage has hindered its application to living cells. We have developed a soft X-ray microscope using femtosecond pulse illumination generated by a soft X-ray free electron laser, with which structural change of cells caused by radiation damage is negligible. Employing Wolter mirrors for illumination and objective optics enabled us to perform soft X-ray imaging with a large field of view, facilitating observation of mammalian cells. We successfully captured images of living cells in culture medium visualizing their carbon distribution. The broad wavelength-tunability of soft X-ray free electron lasers, in conjunction with the achromaticity of Wolter mirrors, enabled wavelength resolved cellular imaging.
Different Basin’s Parameters Investigation of Gravitational Whirlpool Hydropower Turbine
Authors: Moneer Miral Michel , Shehata Ahmed S. , Elsherbiny Khaled , Mehanna Ahmed 
Published: December 2023

Abstract
The rapid growth of renewable energy is heading to use different types of hydropower energy applications. While the water flows at riverine systems, canals, streams, dykes, and channels with low water velocity and ultra-low head of water; several methods are used to enhance the gravitational water vortex turbine. A numerical model has simulated the artificially induced gravitational water vortex and the attached water turbine. A validated model was used to investigate different basin parameters to enhance the overall performance, such as the airfoil types, spacing and the sizing on the basin wall. Results showed that the power coefficient of the runner is improved by using a helical airfoil on the basin wall of thick airfoil with small chord length and narrow spacing. The simulation showed the spacing of 50mm, sizing of 35mm and airfoil of NACA0024 had the best performance. Therefore, airfoil profiles are simulated having the best characteristics of airfoils, sizing and spacing. Whereas the results indicated the NACA0024, sizing of 35mm and spacing of 50mm has the highest hydrodynamics characteristics.
Designing Effective ML Baseline Models using Ensemble and Probability Threshold Tuning Methods: A study on Cardiac Arrhythmia and Hospital Readmissions
Authors: Patel Pooja , Juneja Sanchita , Talaat-Hamid Laura-Amira , Pedebos Lucas , Tissot Hegler 
Published: December 2023

Abstract
As the healthcare industry increasingly adopts Electronic Health Records (EHRs), there is growing interest in leveraging machine learning (ML) algorithms for proactive risk assessments and effective interventions. However, the true potential of ML and artificial intelligence (AI) in healthcare remains largely untapped, lacking a systematic exploration.In this research, our focus is on using effective baseline models in tackling class imbalance in machine learning. To achieve this, we investigate the effectiveness of tuning probability thresholds and applying ensemble methods as a means to improve the F1 score when dealing with complex ML problems.We aim to look at how baseline models perform when designed as ensemble methods with proper tuning probability thresholds using two evaluation tasks: (a) predicting cardiac arrhythmia and (b) hospital readmissions in ICU patients. Leveraging the publicly available MIMIC-III database, we implemented three baseline ML models: Logistic Regression, Extreme Gradient Boosting (XGBoost), and Neural Network (ANN). The main findings from this study demonstrate the effectiveness of ensemble learning methods by combining predictions tailored to specific patient cohorts. Additionally, this study underscores the significance of tuning probability thresholds to enhance F1 scores, especially in handling imbalanced healthcare data. Notably, in both evaluation tasks, XGBoost outperforms ANN models, consolidating it a promising baseline for intricate deep learning applications.
A telomere-to-telomere genome of mango exclusively from long-read sequence data
Authors: Henry Robert , Wijesundara Upendra , Furtado Agnelo , Masouleh Ardy , Dillon Natalie 
Published: December 2023

Abstract
Improvements in long-read sequencing techniques have greatly accelerated plant genome sequencing. Current de novo assemblies are routinely achieved by assembling long-read sequence data into contigs that are assembled to chromosome level by chromatin mapping (Hi-C). We report here a telomere-to-telomere chromosome-level mango genome using only PacBio HiFi long reads. HiFi reads at high coverage (204X) resulted in the assembly of 17 chromosomes each as a single contig with telomeres at both ends. The remaining three chromosomes were represented each by two contigs with telomeres at one end and ribosomal repeats at the other end. Analysing contig ends allowed them to be paired and linked to generate the remaining three complete chromosomes, telomere-to-telomere. The assembled genome was 365 Mb with 100% completeness as assessed by BUSCO analysis. The haplotypes assembled demonstrated extensive structural differences. This approach may be useful for assembling telomere-to-telomere and haplotype-resolved genomes for many other plants.
Economic Values of Some Important Traits for Smallholder Dairy Production in Central Ethiopia
Authors: Demisse Direba Hunde , Tadesse Yosef , Tadesse Million , Biratu Kasa , Shumiye Molla , Yadesa Endale , Wedajo Fikadu , Getahun Kefale , Beneberu Nibo , Gelmesa Ulfina , Getachew Tesfaye 
Published: December 2023

Abstract

Economic value (EV), sensitivity of EV and relative economic importance of milk yield (MY), age at first calving (AFC), calving interval (CI) and herd life (HL) traits were estimated for smallholder dairy cattle production in the central part of Ethiopia. The data on biological and economic parameters were collected using household interview and group discussions methods participating 238 farmers who had crossbred dairy cattle. Bio-economic model was used to calculate EV, sensitivity of EV and relative importance of EV. Cost of animal feed takes the highest share which accounted 81.35% of the total expenditure. The overall average profit per farmers expressed in Ethiopia currency (ETB, 1 US-$ = 39.55696 ETB) was 72,458.10 ± 5068 per year. Profitability of crossbred dairy cattle was significantly varied (p < 0.05) between zones. Economic value estimated for MY, AFC, CI and HL in ETB were 13.38/kg, -16.19/day, -33.58/day and 79.55/day. The associated EV per additive standard deviation were 6083.62, -1311.59, -1271.05 and 117.73 ETB for MY, AFC, CI and HL, respectively. Analysis of sensitivity to scenario change (± 20%) showed that milk price had positive association with profit and EV, whereas feed price has inversely influenced both profit and EV. The profit obtained by farmers was altered by ± 29.08% and ± 12.31% as milk price and feed price fluctuated by ± 20%, respectively. Similarly, the EV of MY was changed by ± 20% with change in milk price and ± 7% with feed price. Scenario change in feed price (± 20%) has also caused ± 13.63% change on EV for AFC and ± 17.58% for CI. It can be noted that profit and EV of the traits were less sensitive to the change in price of milk, feed and labor. In general, the results of EV and profitability were encouraging for dairy farmers and the estimates can be used as an input for development of breeding program in the study area.
Geometry-Based Decomposition Rules and Programming Strategies for Complex Components in Additive and Hybrid Manufacturing
Authors: Saghafi Marzia , Urbanic Ruth Jill , Hedrick Bob , Ramezani Hamoon 
Published: December 2023

Abstract
Additive manufacturing (AM) processes offer a promising avenue for providing service components, primarily due to their inherent advantage of producing components without the need for tooling or fixtures. Nevertheless, many AM processes often necessitate extensive post-processing steps to eliminate support materials and achieve the required surface finishes and feature tolerances. The central objective of this research is to investigate the feasibility of using directed energy deposition (DED) AM solutions to manufacture intricated geometries that are traditionally produced through casting, machining, or forging, leveraging hybrid manufacturing build techniques where machining operations are introduced as needed. DED AM processes with innovative tool paths and build strategies are employed to create a near-net shape, followed by final machining or intermittent machining operations. To structure our approach, we introduce a geometry classification schema, which allows us to group similar build strategies. This classification framework lays the foundation for our decomposition methods and process planning strategies. Some issues, such as overhang geometries and collisions, have been resolved using these specific strategies. It is important to note that this research is ongoing, and in future work, we plan to develop in-line heat maps and explore heating cycles impact on the resulting mechanical, tribological and physical properties of these components. This continued exploration will further enhance our understanding of the potential of DED AM in this context.
Impact of Omicron Infection on Childhood Health: The China Long-COVID Study
Authors: Zhou Bo , Li Minjun , Xu Qi , Li Shaoli , Wang Jianhong , Liu Junting , Zhang Ting , Qu Xia , Wang Xi , Zhang Lili , Liu Xiaoli , Gu Jialu , Zhou Lijun , Chen Fangfang , Zong Xinnan , Niu Wenquan , Wang Lin 
Published: December 2023

Abstract
Purpose
The aim of this prospective study was to assess the dynamic changes of persisting symptoms among children aged 6–18 years during 1–2 months after the Omicron infection based on the modification of SBQ-LC in Tongzhou cohort, Beijing.
Methods
This study includes 4 serial surveys performed on January 7–9, January 14–16, January 21–23 and February 12–14, respectively. The prediction of age and survey for eight domains in the Rasch 0-100 linear score was undertaken by generalized additive mixed model.
Results
Total 1536 children (median age: 13 years, boys: 49.9%) had completed information across 4 surveys. Information on 51 symptoms was collected, with each scored on a 4-point rating scale. Generally, the distribution of age with all domains followed the N-shaped geometry, and that of survey followed the inverse J-shaped geometry. The Rasch linear score hit the lowest level among children aged 6–8 years, and reached the peak among children aged 12–13 years. The scores of all domains sharply declined from the first to the third survey, and remained stable between the third and the fourth survey. At the fourth survey, 95.05% and 51.37% of children still had one or more problems relating to breathing and mental health, respectively, and the percentage of rest six domains was reduced to less than 20%.
Conclusions
Our findings indicate the multifaceted impact of Omicron infection on childhood health, especially among children aged 12–13 years. Moreover, breathing and mental health related problems still persisted during 1-to-2-month Omicron infection period.
NPIP: A Comprehensive Analysis Pipeline for Rapid Pathogen Detection in Clinical Samples Based on Nanopore Sequencing
Authors: Kong Yanhua , Sun Huizhuo , Gao Tongxin , Han Na , Zhang Tingting , Qiang Yujun , Peng Xianhui , Li Xiuwen , Zhang Wen 
Published: December 2023

Abstract
Background: Rapid and accurate pathogen detection is important for effective control of infectious diseases. However, traditional pathogen culture methods have a very long detection time, as well as high rates of false-positive and false-negative results. Third generation sequencing (TGS) technology brings the new possibility of being used as a pathogen detection method. However, the practicability of a pathogen detection report based on TGS is still lacking. There is also a lack of professional and accurate report interpretation.
Results: Here, we report on the development of a pathogen detection and analysis tool (NPIP) based on third generation nanopore sequencing technology. We also prove the practicability of nanopore sequencing and NPIPanalysis tools in emergency and clinical pathogen detection by demonstrating its use in a practical case.
Conclusions: This platform provides an effective, convenient, and fast analysis tool for clinicians and public health personnel to more successfully apply TGS in pathogen detection.