bluuebunny/crossref_metadata_2025_split huggingface dataset:
IBC Oxford University Poster Abstract 27 - Is distalization a good option for insufficient weight loss or weight regain after Roux-en-Y gastric bypass? The initial experience of a differentiated center
Authors: Oliveira A , Santos-Sousa H , Machado M , Coutinho C , Nogueiro J , Lemos J , Peleteiro B , Resende F , Pinho A , Preto J , Freitas P , Carneiro S , da Costa E Lima 
Published: February 2025

Abstract

Introduction
Bariatric surgery is recognized as the most effective long-term treatment for clinically severe obesity, leading to sustained weight loss. Among the common bariatric procedures, the laparoscopic Roux-en-Y gastric bypass (RYGB) is frequently performed and is known for its significant weight loss results and its ability to reduce obesity-related comorbidities in many patients. However, 10% to 40% of patients may experience insufficient weight loss (IWL) or weight regain (WR), along with the persistence or recurrence of comorbidities after 5 to 7 years, presenting a major challenge for bariatric surgeons. The distalisation of RYGB, a revisional malabsorptive procedure, can potentially address these issues but comes with its own complications.

Methods
We reviewed all distalisations of RYGB performed at our hospital between 2019 and 2023. During this period, a total of 2117 RYGB surgeries were performed. The primary outcomes assessed were weight loss progress and changes in comorbidities. Secondary outcomes included early postoperative complications and the need for surgical revisions.

Results
A total of 13 distalisations of RYGB type I (BPL distalisation) were performed, all on female patients with a median age of 49 years. The median BMI was 50.7 kg/m2 at the initial bypass and 41.2 kg/m2 before the distalisation. The median interval between the two surgeries were 103 months. In all the cases, the common limb length was more than 2.5 m and there was a median length of 2.32 m of the biliopancreatic limb. Total weight loss was 27.7% at 6 months, 30% at 1 year (n = 9), 25.2% at 1.5 years (n = 7), and 24.1% at 2 years (n = 6). Among the four patients with hypertension before the revisional surgery, there was one patient with remission at 6 months post-surgery, while the others continued to have hypertension. There were no cases of diabetes mellitus, dyslipidaemia, or sleep apnoea syndrome prior to the surgery. However, one patient developed diabetes mellitus 6 months post-surgery. The average surgery duration was 107 minutes, and patients were discharged after 2 days. There were no complications, and no surgical revisions were required. The median follow-up time was 23 months.

Discussion
Our hospital’s experience with distalisation procedures demonstrates that this surgery is both safe and effective, leading to significant BMI reduction without malnutrition. Furthermore, the initial surgery was highly effective in reducing comorbidities, as most patients had remission of these conditions following gastric bypass.

Conclusions
The limited number of cases hinders our ability to draw definitive conclusions. Increasing the number of cases will be crucial for obtaining more reliable results.
Differential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks
Authors: Qureshi Abid Y , Nielsen Jared A , Sepulcre Jorge 
Published: February 2025

Abstract
Qualitatively different topographical patterns of connections are thought to underlie individual differences in thought and behavior, particularly at heteromodal association areas. As such, we hypothesized that connections unique to 16p11.2 deletion carriers compared to controls, rather than hyper- or hypo-connectivity, would serve as a better model to explain the cognitive and behavioral changes observed in individuals carrying this autism-risk copy number variation. Using a spatially-unbiased, data-driven approach we found that differential links clustered non-uniformly across the cortex—particularly at the superior temporal gyrus and sulcus, posterior insula, cingulate sulcus, and inferior parietal lobule bilaterally. At these hotspots, altered local connectivity that spanned across the borders of cortical large-scale networks coincided with aberrant distant interconnectivity between large-scale networks. This was most evident between the auditory and the dorsomedial default (DNb) networks—such that greater between-network interconnectivity was associated with greater communication and social impairment. Entangled connectivity between large-scale networks may preclude each network from having the necessary fidelity to operate properly, particularly when the 2 networks have opposing organization principles—namely, local specialization (segregation) versus global coherency (integration).
Multi-parameter Persistence Modules are Generically Indecomposable
Authors: Bauer Ulrich , Scoccola Luis 
Published: February 2025

Abstract
Algebraic persistence studies persistence modules (typically, linear representations of the poset $\textbf{R}^{n}$ with $n \geq 1$) and the algebraic relationships between persistence modules that are interleaved. The notion of $\varepsilon $-interleaving between persistence modules is a generalization of the notion of isomorphism (recovering isomorphism when $\varepsilon = 0$), which can be used to quantify how far any two persistence modules are from being isomorphic. An emblematic example of this kind of study is the algebraic stability theorem, which strengthens the Krull–Schmidt property of one-parameter persistence modules (representations of $\textbf{R}$) by generalizing isomorphism to interleaving: If a pair of one-parameter persistence modules is $\varepsilon $-interleaved, then there exists a partial matching between the indecomposable summands of the two modules such that matched indecomposables are $\varepsilon $-interleaved and unmatched indecomposables are $\varepsilon $-interleaved with the zero module. Our first main result implies that the obvious extension of the algebraic stability theorem to the case of multi-parameter persistence modules (representations of $\textbf{R}^{n}$ with $n \geq 2$) fails spectacularly: Any finitely presentable multi-parameter persistence module can be approximated arbitrarily well by an indecomposable module. Our second main result states that modules that are sufficiently close to an indecomposable decompose as a direct sum of an indecomposable and a nearly trivial module. We derive from these two results several consequences about the interplay between the algebraic and the topological properties of multi-parameter persistence modules. These results provide strong motivation for approaching multi-parameter persistence in a way that does not rely on directly decomposing modules by indecomposables.
L-functions for Sp(2n) × GL(k) via Non-unique Models
Authors: Jin Yubo , Yan Pan 
Published: February 2025

Abstract
Let $n$ and $k$ be positive integers such that $n$ is even. We derive new global integrals for $\textrm{Sp}_{2n}\times \textrm{GL}_{k}$ from the generalized doubling method of Cai, Friedberg, Ginzburg, and Kaplan, following a strategy and extending a previous result of Ginzburg and Soudry on the case $n=k=2$. We show that these new integrals unfold to non-unique models on $\textrm{Sp}_{2n}$. Using the New Way method of Piatetski-Shapiro and Rallis, we show that these new global integrals represent the $L$-functions for $\textrm{Sp}_{2n}\times \textrm{GL}_{k}$, generalizing a previous result of the second-named author on $\textrm{Sp}_{4}\times \textrm{GL}_{2}$ and a previous work of Piatetski-Shapiro and Rallis on $\textrm{Sp}_{2n}\times \textrm{GL}_{1}$.
Mitochondrial RNA metabolism, a potential therapeutic target for mitochondria-related diseases
Authors: Duan Tongyue , Sun Liya , Ding Kaiyue , Zhao Qing , Xu Lujun , Liu Chongbin , Sun Lin 
Published: February 2025

Abstract
In recent years, the roles of mitochondrial RNA and its associated human diseases have been reported to increase significantly. Treatments based on mtRNA metabolic processes and nuclear gene mutations are thus discussed. The mitochondrial oxidative phosphorylation process is affected by mtRNA metabolism, including mtRNA production, maturation, stabilization, and degradation, which leads to a variety of inherited human mitochondrial diseases. Moreover, mitochondrial diseases are caused by mitochondrial messenger RNA, mitochondrial transfer RNA, and mitochondrial ribosomal RNA gene mutations. This review presents the molecular mechanisms of human mtRNA metabolism and pathological mutations in mtRNA metabolism-related nuclear-encoded/nonencoded genes and mitochondrial DNA mutations to highlight the importance of mitochondrial RNA-related diseases and treatments.
Crisis Management and Problem-Solving Skill Levels of Nurses Caring for Patients With COVID-19 and Affecting Factors
Authors: Kesemen Cansu , Polat Ülkü 
Published: February 2025

This study aims to assess the crisis management and problem-solving skills of nurses caring for patients with COVID-19. The participants of this descriptive cross-sectional were 132 nurses who cared for patients with COVID-19 in a public hospital. The crisis management scale (CMS), problem-solving inventory (PSI), and Nurse Introduction Form were used to collect data. In this study, the nurses’ CMS total score average was 3.75 ± 0.442, the average PSI total score was 86.32 ± 24.420, and it was determined that their crisis management ability was at a good level and their problem-solving skills were at a medium level. A significant difference was found between the nurses’ descriptive characteristics of having children (P = .029), being informed about crisis management (P = .035), and their total average score on the CMS (P < .05). A statistically significant negative relationship was found between the nurses’ total CMS and PSI scores (P < .05).This study showed that the problem-solving skill levels of nurses caring for patients with COVID-19 affected their crisis management skills.
Efficacy and safety of PD-1/PD-L1 inhibitor monotherapy or combination therapy versus platinum-based chemotherapy as a first-line treatment of advanced urothelial cancer: A systematic review and meta-analysis
Authors: He Xiaohui , Huang Shibo , Jiang Qiuhong , Huang Conghui , Huang Weisheng , Liang Weiming 
Published: February 2025

Abstract

Background
Recent clinical trials have shown that inhibitors targeting programmed cell death protein 1 (PD-1) or its ligand (programmed cell death-ligand 1 [PD-L1]) provide significant efficacy and clinical benefit in the treatment of advanced or metastatic urothelial carcinoma. This systematic review and meta-analysis aimed to compare the effectiveness and safety of PD-1/PD-L1 inhibitors in combination with chemotherapy or PD-1/PD-L1 inhibitor monotherapy versus platinum-based chemotherapy as a first-line treatment for advanced urothelial carcinoma.

Materials and methods
From the beginning of the database construction to February 4, 2024, a combination of MeSH and free-text words was searched using the population intervention comparison outcome study design framework. The PubMed, Cochrane Library, Embase, and Web of Science electronic databases were searched. Meta-analyses of progression-free survival, overall survival, objective response rate (ORR), complete remission rate, duration of remission, and grade ≥3 adverse events were performed.

Results
Four studies were included in the meta-analysis. The PD-1/PD-L1 inhibitors plus chemotherapy therapy is associated with significantly better ORR rate compared with chemotherapy. Unfortunately, there were no significant differences between PD-1/PD-L1 inhibitor monotherapy and chemotherapy in terms of ORR, duration of remission, or overall survival.

Conclusions
Our findings indicate that PD-1/PD-L1 inhibitors plus chemotherapy therapy provides more oncological advantages than standard chemotherapy and should be recommended as a first-line treatment for advanced or metastatic urothelial carcinoma. Attention must also be paid to the adverse effects of the combination of PD-1/PD-L1 inhibitors and chemotherapy.
Efficacy and safety of a fully covered self-expandable metallic stent equipped with square flare in EUS–guided drainage/anastomosis: A multicenter retrospective study
Authors: Takahashi Sho , Matsubara Saburo , Fujisawa Toshio , Otsuka Takeshi , Suda Kentaro , Ushio Mako , Fukuma Taito , Suzuki Akinori , Takasaki Yusuke , Ito Koichi , Tomishima Ko , Ishii Shigeto , Nagoshi Sumiko , Isayama Hiroyuki 
Published: February 2025

ABSTRACT

Background and Objectives
Recent technological advances in interventional EUS have improved EUS-guided drainage/anastomosis (EUS-D/A), yet challenges remain. This study evaluated the safety and feasibility of a square flare fully covered self-expandable metallic stent (SF-FCSEMS) with anti-migration properties for EUS-D/A.

Methods
This retrospective cohort study was performed at 2 academic centers and analyzed patients who underwent SF-FCSEMS placement for EUS-D/A from April 2015 to November 2022. We have used an SF-FCSEMS that has a square flare at both ends that is 4 mm larger in diameter than the stent body, providing an anti-migration effect.

Results
Thirty-six patients (median age: 74 years), 41.6% male, were included. Malignancies accounted for 83.3%. Among the EUS-D/A procedure types, EUS-abscess drainage was performed in 52.8%, EUS-guided gallbladder drainage in 30.6%, and EUS-guided abscess drainage in 16.7%. The technical success rate was 97.2%, and the clinical success rate was 97.1%. The median procedure time was 36 minutes, with puncture tract dilation conducted in all cases. Adverse events occurred in 11.1%; recurrent symptoms were observed in 11.8%, with no migration. SF-FCSEMS removal was performed in 26.5% of patients during the follow-up period, with a median duration of 154 days. The total cost of deploying SF-FCSEMS was approximately 40% less than that of using lumen apposing metal stent.

Conclusions
EUS-D/A with an SF-FCSEMS, which has anti-migration properties, not only was effective and feasible in the present study but also demonstrated a cost advantage.
Multiple features of cell-free mtDNA for predicting transarterial chemoembolization response in hepatocellular carcinoma
Authors: Dang Miao , Wang Siyuan , Peng Fan , Zhang Runjiao , Jiao Huanmin , Zhang Huanqin , Dong Haiying , Zhang Hongxin , Xing Jinliang , Guo Xu , Liu Yang 
Published: February 2025

Background:
Transarterial chemoembolization (TACE) is the primary treatment modality for advanced HCC, yet its efficacy assessment and prognosis prediction largely depend on imaging and serological markers that possess inherent limitations in terms of real-time capability, sensitivity, and specificity. Here, we explored whether multiple features of cell-free mitochondrial DNA (cf-mtDNA), including copy number, mutations, and fragmentomics, could be used to predict the response and prognosis of patients with HCC undergoing TACE treatment.

Methods:
A total of 60 plasma cell-free DNA samples were collected from 30 patients with HCC before and after the first TACE treatment and then subjected to capture-based mtDNA sequencing and whole-genome sequencing.

Results:
Comprehensive analyses revealed a clear association between cf-mtDNA multiple features and tumor characteristics. Based on cf-mtDNA multiple features, we also developed HCC death and progression risk prediction models. Kaplan-Meier curve analyses revealed that the high-death risk or high-progression–risk group had significantly shorter median overall survival (OS) and progression-free survival than the low-death risk or low-progression-risk group (all p<0.05). Moreover, the change in cf-mtDNA multiple features before and after TACE treatment exhibited an exceptional ability to predict the risk of death and progression in patients with HCC (log-rank test, all p<0.01; HRs: 0.36 and 0.33, respectively). Furthermore, we observed the consistency of change between the cf-mtDNA multiple features and copy number variant burden before and after TACE treatment in 40.00% (12/30) patients with HCC.

Conclusions:
Altogether, we developed a novel strategy based on profiling of cf-mtDNA multiple features for prognosis prediction and efficacy evaluation in patients with HCC undergoing TACE treatment.
N-Acetylcysteine for Nonsuicidal Self-Injurious Behavior in 3 Adults With Williams Syndrome
Authors: Kandel Hagar , Cruz Ava R. , Thom Robyn P. , McDougle Christopher J. 
Published: February 2025

Abstract

Background
Williams syndrome (WS) is a genetic disorder that results from a microdeletion of 25 to 27 genes on chromosome 7q11.23. Individuals with WS often exhibit comorbid neuropsychiatric symptoms, especially anxiety. To our knowledge, nonsuicidal self-injurious behavior (NSSIB) has not been reported in WS. N-acetylcysteine (NAC) is a safe and readily available drug that may modulate glutamate activity in the brain. NAC is effective for treating various neuropsychiatric symptoms and disorders. There are limited reports in the literature where NAC has been used to treat NSSIB effectively, but none in WS.

Methods
This report describes using NAC to treat NSSIB in 3 adults with WS.

Findings
Nonsuicidal self-injurious behavior was successfully treated in 3 adults with WS using NAC in doses ranging from 2400 to 3600 mg a day, resulting in significant improvement in their daily functioning. Additionally, NAC was well tolerated.

Conclusions
NAC was effective for treating NSSIB in 3 adults with WS. By addressing these challenging behaviors, NAC offers a promising pharmacological intervention that can significantly improve the quality of life for patients with WS who engage in NSSIB. Further research and clinical trials are necessary.
Beyond Borders, Beneath Words: Using Natural Language Processing to Map Student Reflections on International Service Learning to Physical Therapy Values
Authors: Borstad Alexandra L. , Appling Susan A. , Kloos Anne D. , Spangler Lynda , Marc David T. 
Published: February 2025

Introduction.
Advances in artificial intelligence (AI) offer physical therapy educators opportunities to improve student learning. We applied AI to identify themes and determine the extent to which physical therapy professional values were reflected upon by students during a high-impact international service learning (ISL) course in México.

Review of Literature.
Natural language processing (NLP), a subfield of AI, organizes and interprets language nuances, efficiently providing insight into the meaning expressed in written work. Efficient methods to measure written work are needed.

Subjects.
Reflection statements (n = 802) from 21 third-year, Doctor of Physical Therapy students were analyzed.

Methods.
Natural language processing methods executed in the R statistical software were K-means clustering to parse reflections by theme, and the semantic distance metric, cosine similarity (cos θ), to quantify the similarity of meaning between reflections and 7 physical therapy professional values.

Results.
Using NLP, 3 themes emerged in the reflections: educating patients and caregivers, providing new treatment ideas, and learning about a different culture. Eighty-four percent of reflections were highly similar (cos θ = 0.59) to the value excellence. Reflections were also highly similar to integrity (cos θ = 0.61) and compassion and caring (cos θ = 0.51) and least similar to professional duty (cos θ = 0.24). Reflections on the theme of learning about a different culture were most similar to 5 of the 7 values compared with other themes.

Discussion and Conclusion.
Natural language processing enabled a detailed understanding of the values woven throughout students' written reflections on ISL. The experience implicitly promoted the development of physical therapy core values, in particular excellence, affirming it as a high-impact educational practice for professional development. Natural language processing's automated, quantitative, and debiased outcomes advance reflection analytics, an example of one of the new and powerful approaches AI offers educators and researchers that will transform our field.
Merkel cell carcinoma in a patient with basal cell carcinoma: a case of localized disease with negative sentinel node biopsy
Authors: Shahani Hiba Arshad , Ali Masab , Babar Ilsa , Javeria Sana , Ahmad Muhammad Husnain , Saeed Humza , Ahmad Uswa , Sehbai Aasim 
Published: February 2025

Introduction:
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer with a high risk of recurrence and metastasis. It typically affects sun-exposed areas in elderly or immunocompromised individuals. Early diagnosis and management are essential due to its rapid progression and potential for early metastasis.

Case presentation:
We report the case of a 65-year-old male with a history of diabetes mellitus and basal cell carcinoma who developed MCC on his left upper extremity. Initial imaging, including a sentinel lymph node biopsy (SLNB) and magnetic resonance imaging (MRI), localized the tumor and assessed lymph node involvement. The SLNB was negative for metastasis, and a wide excision confirmed no residual MCC. Further imaging with positron emission tomography (PET) and computed tomography (CT) scans showed no distant metastasis, indicating localized disease. The patient underwent wide excision followed by radiation therapy (RT) (50 Gy in 25 fractions), experiencing mild post-radiation effects such as swelling and erythema.

Clinical discussion:
MCC poses significant diagnostic and therapeutic challenges due to its nonspecific presentation and rapid progression. In this case, early detection and appropriate imaging allowed for timely intervention. Negative SLNB results and localized disease justified the use of wide excision and MC. Multimodal treatment, including surgery and radiation, is crucial in managing localized MCC.

Conclusion:
This case emphasizes the importance of early detection, comprehensive imaging, and multimodal therapy in the management of MCC. Close follow-up remains essential, especially in cases with negative SLNB, to monitor for recurrence or metastasis.
Referral to Geriatric Rehabilitation in the Netherlands, an Exploratory Study of Patient Characteristics
Authors: de Groot Aafke J. , Wattel Elizabeth M. , van Balen Romke , Hertogh Cees M. P. M. , van der Wouden Johannes C. 
Published: February 2025

Abstract

Purpose
Geriatric rehabilitation is intended for older adults with vulnerability, comorbidity, and acute functional impairments. To explore and evaluate referral criteria, this study followed hospital patients referred for rehabilitation in nursing homes.

Design
Exploratory, retrospective cohort study.

Methods
Participants were community living before acute hospitalization and referred for geriatric rehabilitation between January 15 and May 15, 2019. Data were collected at hospital admission, hospital discharge, and discharge from rehabilitation-oriented care. Outcome measure was the final discharge destination.

Results
Out of 87 hospital patients referred for rehabilitation (mean age = 76.3 years, SD = 10.7), 73 received rehabilitation-oriented post-acute care and 60 (82.2%) returned home after rehabilitation. Premorbid functional status was regained by 45 (61.6%) participants and mobility by 40 (54.8%). Independent baseline mobility, no complications during post-acute care, fewer cognitive symptoms, and multidomain vulnerability were associated with discharge destination after rehabilitation.

Clinical Relevance to Rehabilitation Nursing
A multidomain assessment can make vulnerability applicable in referral decisions and induce tailored individual rehabilitation programs.

Conclusion
This study explored the case-mix characteristics of hospital patients following rehabilitation trajectories. No frailty measures were available; vulnerability was refined into physical, cognitive, and social components. Careful assessment of vulnerability can support personalized referral decision-making.