bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photochemische Untersuchungen an Farbstoffen. I: Chemismus der Phototropie von Kupferphtalocyanin‐Farbstoffen
Authors: Eigenmann G. 
Published: December 2004

AbstractThe photochemically induced change of colour of dyes derived from copper‐(II)‐phthalocyanine in presence of certain nitrogen‐containing crease‐resist resins was investigated by means of optical and electronspinresonance spectroscopy and by photo‐potentiometric methods. It is shown to be due to a light induced reversible one‐electron reduction of the copper (II)‐phthalocyanine.
Über die Chemie des Vitamins E. 1. Mitteilung. Die Umkehrung der Konfiguration am Kohlenstoffatom 2 von natürlichem (2 R, 4′ R, 8′ R)‐α‐Tocopherol
Authors: Schudel P. , Mayer H. , Metzger J. , Rüegg R. , Isler O. 
Published: December 2004

Abstract(2 S, 4′R, 8′R)‐α‐Tocopherol with unnatural configuration at C‐2 is prepared by oxidation of natural, so called d‐α‐tocopherol (I), which has the (2R, 4′R, 8′R)‐configuration, to α‐tocopherylquinone (II), followed by recyclization of the corresponding α‐tocopherylhydroquinone (III). Experiments showed that the configuration of carbon atom 2 of natural α‐tocopherol is retained during the ferric chloride oxidation (I →II) and is predominantly inverted by zinc chloride cyclization of α‐tocopherylhydroquinone (III).
Über Reaktionen von Alkoxyradikalen. Epimerisierungen in der Steroidreihe. Über Steroide, 194. Mitteilung
Authors: Heusler K. , Kalvoda J. , Anner G. , Wettstein A. 
Published: December 2004

AbstractThe lead ester formed from steroidal alcohols with lead tetraacetate are thermally decomposed to oxy radicals which can either form tetrahydrofurane derivatives by direct attack on a hydrogen atom at δ‐carbon atom or, by cleavage of the α,β‐carbon bond, give rise to a carbonyl group and a carbon radical. The latter reaction is shown to be reversible in certain cases and the recyclisation can yield oxy radicals epimeric at one or both of the α and β carbon atoms.
Synthese eines 1‐Oxa‐phenalen‐Derivates mit dem chromophoren System des Biflorins
Authors: Grant Heather N. , Prelog V. , Sneeden R. P. A. 
Published: December 2004

AbstractSeveral derivatives of 1‐oxaphenalene (II) and 1‐oxaphenalene‐7,8‐quinone have been synthesized in order to support the constitution I of biflorin by comparison of the absorption spectra.
Über die Struktur des Kopsins
Authors: Govindachari T. R. , Pai B. R. , Rajappa S. , Viswanathan N. , Kump W. G. , Nagarajan K. , Schmid H. 
Published: December 2004

AbstractDie Experimente, die zur Ableitung der Formel I für Kopsin, dem Hauptalkaloid aus Kopsia fruticosa, führten, werden beschrieben.
Synthesen in der Polymyxin‐Reihe. 7. Mitteilung. Synthese des hochaktiven cyclischen Decapeptids 7α
Authors: Studer R. O. , Lergier W. , Vogler K. 
Published: December 2004

AbstractThe synthesis of an antibiotic substance to which we assign the structure 7α, one of the four possible formulas proposed for natural polymyxin B1, is reported. Although both synthetic and the natural product have the same antimicrobial activity towards Brucella bronchiseptica in vitro (plate test), they are not identical, as shown by the lower optical rotation of the synthetic material.
Über die Chemie des Vitamins E. 2. Mitteilung. Die Struktur des Kaliumferricyanid‐Oxydationsproduktes von α‐Tocopherol
Authors: Schudel P. , Mayer H. , Metzger J. , Rüegg R. , Isler O. 
Published: December 2004

AbstractThe structure of the main oxidation product of natural (2R, 4′R, 8′R)‐α‐tocopherol with potassium ferricyanide is shown to be XXIII.
Über die Chemie des Vitamins E. 3. Mitteilung. Die Totalsynthese von (2R, 4′R, 8′R)‐ und (2S, 4′R, 8′R)‐α‐Tocopherol
Authors: Mayer H. , Schudel P. , Rüegg R. , Isler O. 
Published: December 2004

Abstract(2R, 4′R, 8′R)‐ and (2S, 4′R, 8′R)‐α‐tocopherol have been synthesized by WITTIG reaction of the two enantiomeric S‐(+)‐ and R‐(−)‐6‐acetoxy‐Z‐formyl‐2,5,7, 8‐tetramethyl‐chromans (I) with (3R, 7R)‐hexahydrofarnesyl‐triphenylphosphonium bromide (II), followed by hydrogenation and hydrolysis. (2R, 4′R, 8′R)‐α‐tocopherol proved to be identical in every respect with natural so called d‐α‐tocopherol. Resolution of the chroman component was achieved via the diastereomeric quinine salts of 2‐carboxyethynyl‐6‐hydroxy‐2,5,7,8‐ tetramethyl‐chroman (XVIII). followed by transformation of the enantiomers into S‐(+)‐ and R‐(−)‐I, respectively.
Das Mischpotential und seine Berücksichtigung bei der Konstruktion von elektrometrischen Flächen
Authors: Milí ević B. 
Published: December 2004

AbstractFor two simple examples the mixed potential is discussed and the three‐dimensional models of the voltametric and chrono‐electrometric processes with two electronexchanger pairs are given. The potential possibility of the «zero‐current chronopotentiometry» is outlined.
Ein neuer Carotinoidfarbstoff: 4′‐Hydroxykryptoxanthin
Authors: Karrer P. , Jaeger L. 
Published: December 2004

AbstractDurch Oxydation von Kryptoxanthin mittels N‐Bromsuccinimid in Gegenwart von Eisessig und nachfolgende Verseifung erhält man das bisher unbekannte 4′‐Hydroxykryptoxanthin.
Welkstoffe und Antibiotika. 25. Mitteilung. Synthese der natürlichen Dehydrofusarinsäure
Authors: Steiner K. , Graf U. , Hardegger E. 
Published: December 2004

AbstractDie Synthese der natürlichen Dehydrofusarinsäure (VI) gelang in guter Ausbeute durch Alkyliercing der leicht zugänglichen 5‐Methyl‐2‐picolinsäure (V) mit Allylchlorid. Die unnatürliche Δα,β‐Dehydrofusarinsäure (111), sowie die Bis‐dehydrofusarinsäure (VII) wurden nach Modell‐Versuchen am 3‐Butyl‐pyridin (Ia) gemäss Formelschema aus Fusarinsäure (I) hergestellt.
Synthese einiger Thioxanthen‐Derivate
Authors: Schindler O. , Lehner H. , Michaelis W. , Schmutz J. 
Published: December 2004

AbstractThe synthesis of some thioxanthene derivatives as possible metabolites of Methixerc (VI‐hydrochloride) is described. The VON BRAUN degradation of VI with cyanogen bromide leads to the demethyl derivative 9‐ [(3‐piperidyl)‐methyl]‐thioxanthene (VIII). Oxidation of Methixen with hydrogen peroxide at 20° gives a mixture of the two steroisomerie sulfoxides IX and X; they were separated by preparative paper‐chromatography. The same oxidant at 100° oxidizes Methixelz to the sulfone IV. This was also obtained by alkylation of thioxanthene‐10, 10‐dioxide (11). On oxidation with hydrogen peroxide the demethyl derivative VIII affords at 20° the sulfoxide XI (isolated in non‐uniform steric state), and at 100° the sulfone V. Alkylation of thio‐xanthene with N‐methyl‐3‐chloromethyl‐piperidine‐N‐oxide (I) leads to ‐[(N‐ methyl‐3‐piperidyl)‐methyl]‐thioxanthene‐N‐oxide (111), the constitution of which was proved by conversion to VI.
Zur Kenntnis der sogenannten «Alkalicarbonyle» I Die Kristallstruktur des Kalium‐acetylendiolats, KOCCOK
Authors: Weiss E. , Büchner W. 
Published: December 2004

AbstractThe structure of the yellow «potassium carbonyl», obtained from CO and K in liquid ammonia, has been shown to be potassium acetylenediolate, KOCCOK. From X‐ray powder‐diagrams a tetragonal cell containing two KOCCOK units with a = 3.93, Å, c = 12.75 Å (space group I 4/mmm) has been derived. The KOCCOK units are arranged parallel to the c‐axis with the following internuclear distnaces: K0: 2.67 and 2.78 Å; KK: 3.65 Å; C0 : 1.28 Å; CC: 1.21 Å.
Synthesen in der Isochinolinreihe Substituierte 1‐[ω‐(Nitrophenyl)alkyl]‐1,2,3,4‐tetrahydro‐isochinoline
Authors: Walter M. , Besendorf H. , Schnider O. 
Published: December 2004

AbstractThe synthesis of substituted 1‐[ω‐(nitrophenyl)alkyl]‐l,2,3,4‐tetrahydro‐iso‐quinolines and their resolution into optical antipodes are described. Some of these l‐[ω‐(nitrophenyl)alkyl]‐l,2,3,4‐tetrahydro‐isoquinolines are potent analgesics.
Die sterische Anordnung der 1:2‐Metallkomplexfarbstoffe im Lichte der geometrischen Gegebenheiten
Authors: Schetty G. 
Published: December 2004

AbstractPrevious investigations of the 1:2‐Cr (and ‐Co) complexes have lead to the conclusion that the azo (and azomethine) dyestuffs which form 56‐rings with the metal atom are arranged perpendicularly to each other (DREW‐PFITZNER disposition). On the other hand those dyestuffs which form 6–6‐rings with the metal atom coordinate in sandwiches, thus making the formation of stereoisomeric 1 : 2‐complexes possible. The critical atomic distances and angles have been calculated and compared with the theoretical values obtained from the coordination octahedron, and found to be in good agreement with the experimental results.
Sekundäre Isotopeneffekte der Aciditätskonstanten kerndeuterierter Anilinium‐Ionen
Authors: Bernasconi C. , Koch W. , Zollinger Hch. 
Published: December 2004

Abstract(1) Acidity constants of 2,3,4,5,6‐d5‐, 2,4,6‐d3‐ and 3,5‐d2‐anilinium ion, of 2,6‐d2−4‐toluidinium and 4‐d‐2,6‐xylidiniumion have been measured in aqueous solution.
Die Glykoside der Blätter von Digitalis canariensis L., var. isabelliana (WEBB) LINDINGER
Authors: Pavanaram S. K. , Hofer P. , Linde Horst , Meyer Kuno 
Published: December 2004

AbstractDie durch Ausschiitteln eines aus getrockneten Blättern von Digitalis canariensis L., vai. isabelliana bereiteten wässerigen Auszuges mit Äther und Chloroform gewonnenen Extrakte wurden einer eingehenden Analyse unterzogen. Im Ätherauszug konnten neben den bereits in der vorangegarigenen Mitteilung beschriebenen Monosiden a, b und c und den Cardenoliden Digitoxigenin (nicht isoliert) und Uzarigenin die folgenden Substanzen kristallisiert werden : ein gelbes Pigment der Formel C16H12O3 (Methyl‐methoxy‐anthrachirion ?), ein Gitoxigenin‐Glykosid (= Substanz J), dessen Konstitution nicht abgeklart werden konnte, und γ‐Sitosterin. Letzteres ist damit zum ersten Mal in einer Digitalispflanze nachgewiesen worden. ‐ Aus dem Chloroformextrakt liessen sich die Digitanol‐glykoside Digifolein, Diginin und 14 α Digipronin in Kristallen isolieren, während Lanafolein, das nur in Spuren vorhanden war, sowohl papier‐ als auch dünnschicht‐chromatographisch nachgewiesen werden konnte. Ausserdem liessen sich zwei für D. isabelliana neue digitaloide Glykoside, nämlich Strospesid und in sehr geringer Menge ein vermutlich unbekanntes Digitalosid (= Substanz K) isolieren.
Hydroxamatkomplexe II. Die Anwendung der pH‐Methode
Authors: Anderegg G. , L'Eplattenier F. , Schwarzenbach G. 
Published: December 2004

AbstractThe equilibria between acethydroxamic acid and 16 metal cations, and their complexes have been elucidated. For the results see table 1. The complex Formation of desferri‐ferrioxamine B and desferri‐ferrioxamin E, which are trihydroxamic acids, with various bivalent and trivalent metal ions have been studied in a similar manner. For the results see tables 2 and 3.
Hydroxamatkomplexe III. Eisen(III)‐Austausch zwischen Sideraminen und Komplexonen. Diskussion der Bildungskonstanten der Hydroxamatkomplexe
Authors: Anderegg G. , L'Eplattenier F. , Schwarzenbach G. 
Published: December 2004

AbstractThe iron transfer from sideramines to suitably chosen complexones (EDTA and similar compounds) has been studied optically. From the equilibrium constants of such exchange reactions the stability constants of Ferrioxamine B, Ferrioxaminc D1, Ferrioxamine E, Ferrichrom and Ferrichrysin have been deduced. For the results see table 5.
Über den Einbau des Kohlenstoffs der Glucose in die Harnsäure bei Drosophila melanogaster. Vorläufige Mitteilung
Authors: Brenner‐Holzach O. , Leuthardt F. 
Published: December 2004

Abstract1. Uric acid was isolated from larvae of Drosophda melanogaster to which glucose‐[1‐14C] and glu∼ose‐[6‐14C] had been fed. The specific activity of the atoms 2 and 8 of the purine skeleton was considerably higher after feeding glucose‐ [6–14C] than after glucose‐ [1‐14C]. The activated formate used in building the purine ring probably derives from the C 3 of glyceric acid (glycerate → hydroxypyruvate → serine).
Le rôle du catalyseur dans la cyclisation des esters glutamiques
Authors: Hubert A. J. , Buyle R. , Hargitay B. 
Published: December 2004

AbstractLactam formation from glutamic acid diesters is subject to catalysis by carbo‐xylic acids in general and to base catalysis in alcohols. Kinetic measurements prove that catalysis by carboxylic acids is based on a push‐pull mechanism provoked by the undissociated acid molecule and that the base catalysed reaction is due to the alcoholate anion and is therefore absent in aprotic solvents. Carboxylic acids exhibit catalysis as well as ‐ at higher concentration ‐ inhibition.
Etude de structures peptidiques à l'aide de phénylisothiocyanate IV. Note sur la préparation et la purification des phénylthiohydrantoïnes dérivées de divers acides aminés
Authors: Cherbuliez Emile , Marszalek J. , Rabinowitz J. 
Published: December 2004

AbstractThe authors describe modified procedures for the synthesis of phenylthiohydantoins derived from α‐amino acids, applied to 16 amino acids. With the exception of the phenylthiohydantoins containing a free NH2, CONH2, COOH or hetero‐cyclic group belonging to the starting amino acid, they can be purified by sublimation. The yield of chromatographically pure product vary between 54 yo (threonine) and 92% (tyrosin); with asparagine, the yield did not exceed 49%.
Recherches sur la formation et la transformation des esters XLII. Sur la phosphorylation de différents types d'alcools, et particulièrement d'alcools non saturés
Authors: Cherbuliez Emile , Cǒak‐Antić Sl. , Schwarz M. , Rabinowitz J. 
Published: December 2004

AbstractTertiary alcohois and terpenic alcohols cannot be phosphorylated by means of polyphosphoric acid or phosphorus pentoxide even in the presence of a tertiary base.
Synthese von Zwischenprodukten für den Aufbau corticotrop wirksamer Polypeptide. V. Derivate des Pentapeptids H · Val‐Lys‐Val‐Tyr‐Pro · OH (β20–24‐Corticotropin) und des diastereoisomeren Peptids H · Val‐lys‐Val‐Tyr‐Pro · OH
Authors: Schwyzer R. , Riniker B. , Kappeler H. 
Published: December 2004

AbstractVarious syntheses of L‐Valyl‐Nϵ‐t‐butoxycarbonyl)‐L‐lysyl‐L‐valyl‐L‐tyroxyl‐L‐proline t‐butyl ester (IX) are described. Condensations involving dicyclohexyl carbodiimide and either p‐phenylazo‐benzyloxycarbonyl‐L‐valyl‐(Nϵ‐t‐butoxycarbonyl)‐L‐lysine (VII), carbobenzoxy‐L‐valyl‐(Nϵ‐t‐butoxycarbonyl)‐L‐lysine (XI), or carbo‐benzoxy‐L‐valyl‐L‐tyroxine (I) produce about 25 per cent racemisation of the C‐terminal amino acids. Carbobenzoxy‐L‐valyl‐(Nϵ‐t‐butoxycarbonyl)‐D‐lysyl‐L‐valyl‐L‐tyrosyl‐L‐proline t‐butyl ester (XIIa) was isolated as a cristalline compound with the same m. p. as the «all‐L»‐isomer. Configurations were determined by teh action of trypsin on lysyl peptides and by the action of L‐amino‐acid oxidase on acid hydrolysates.
Über die Geschwindigkeit der Aminolyse von verschiedenen neuen, aktivierten, N‐geschützten α‐Aminosäure‐phenylestern, insbesondere 2,4,5‐Trichlorphenylestern
Authors: Pless J. , Boissonnas R. A. 
Published: December 2004

AbstractA comparison of the ate of aminolysis of many substituted phenyl esters of N‐protected α‐amino‐acids shows that the 2,4,5‐trichlorophenyl esters are promising new active derivatives for the synthesis of peptides.
Synthèse de la Sér4‐oxytocine, de l'Ala4‐oxytocine, de la Sér5‐oxytocine et de l'Ala5‐oxytocine
Authors: Guttmann St. , Boissonnas R. A. 
Published: December 2004

AbstractSer4‐oxytocin and Ala4‐oxytocin have been synthesized and found to possess biological properties not very different from those of isotocin. Ser5‐oxytocin and Ala5‐oxytocin have also been prepared and found to be almost inactive. An hypothesis concerning the mode of fixation of oxytocin on its receptor is presented.
Synthèse de l'Orn8‐vasopressine et de l'Orn8‐oxytocine
Authors: Huguenin R. L. , Boissonnas R. A. 
Published: December 2004

AbstractOrn8‐vasopressin and Orn8‐oxytocin have been synthesized and their biological activities compared with those of arginine‐vasopressin and lysine‐vasopressin and of arginine‐vasotocin and lysine‐vasotocin, respectively. The replacement of the arginine or lysine residues by an ornithin residue to not considerably affect the oxytocic and pressorie activities.
Tricyclo[2,2,2,02,6]octan und Tricyclo[2,2,2,02,6]oct‐7‐en Konjugation in Cyclopropyl‐äthylenen. Bicyclo[2. 2. 2]octan‐Reihe, 6. Mitteilung
Authors: Grob C. A. , Hostynek J. 
Published: December 2004

Abstract3,5‐Dibromo‐tricyclo[2.2.2.02,6]octane (3), which is obtained by homoconjugative addition of bromine to bicyclo[2.2.2]octa‐2.5‐diene (1), is shown by NMR.‐spectroscopy to be a mixture containing ca. 72% of the trans stereoisomer 13 and ca. 28% of a cis stereoisomer, presumably the exo‐cis from 11. Upon treatment with zinc in dimethylformamide these tricyclic dibromides 3 revert to the diene 1. Hydrogenation over nickel produces bicyclo[2.2.2]octane (15) and a small amount of tricyclo‐[2.2.2.02,6]octane (4), which has been synthesized from bicyclo[2.2.2]octan‐2‐one (16) by a Bamford‐Stevens reaction. In addition to the diene 1, Cope‐elimination of 2‐(dimethylamino‐N‐oxido)‐bicyclo[2.2.2]‐oct‐5‐ene (9) produces small amounts of the abnormal 1,3‐elimination product tricyclo[2.2.2.02,6]oct‐7‐ene (5). The latter compound has been prepared in high yield by a Bamford‐Stevens reaction on bicyclo[2.2.2]oct‐2‐en‐5‐one (23). In tricyclo[2.2.2.02,6]oct‐7‐ene (5) the plane of the double bond symmetrically bisects the cyclopropane ring. Strong conjugation of the cyclopropyl‐ethylene system is indicated by the UV.‐absorption maximum at 206 mμ (log ϵ = 3.71), which shows a bathochromic shift of 23 mμ with respect to cyclohexene.
Organische Phosphorverbindungen VII. Zur Kenntnis der Reaktion von Phenylphosphin mit Schwefel
Authors: Maier Ludwig 
Published: December 2004

AbstractBei der Umsetzung von Phenylphosphin mit Schwefel im Molverhältnis 1:1 bildet sich Phenylphosphinsulfid, dem die Thionostruktur C6H5P(S)H2 und nicht die isomere Thiolstruktur C6H5P(SH)H zukommt. Phenylphosphinsulfid ist instabil und zersetzt sich unter Bildung von Tetraphenyl‐cyclo‐tetraphosphin‐monosulfid, [(C6H5)P]4S, Schwefelwasserstoff und Phenylphosphin.
Recherches sur la formation et la transformation des esters XLIV. Sur l'action de l'oxyde phénylphosphonique sur des alcools non saturés, des hydroxy‐éthers, des alcools cycliques et le phénol
Authors: Cherbuliez Emile , Čolak‐Antić Sl. , Gabbai A. , Hunkeler F. , Gowhari M. , Rabinowitz J. 
Published: December 2004

AbstractEthenic alcohols, ethynic tertiary alcohols, hydroxy ethers, cyclic alcohols, araliphatic alcohols, and phenol react very easily with phenyl phosphonic oxide to yield the corresponding phosphonic monoesters.
Etudes sur les matières végétales volatiles CLXXXVIII. Sur l'absorption d'alcools terpéniques aliphatiques dans l'ultra‐violet, de 185 à 225 mμ
Authors: Naves Yves‐René , Frei Charles 
Published: December 2004

AbstractThe ultra‐violet spectra of a number of aliphatic terpene and sesquiterpene alcohols together with their ydrogenated derivatives have been measured between 185 and 225 mμ.
Über Protonenresonanz‐Spektren von Pteridinen III. Zur Struktur von 9‐Acetonylxanthopterin und Erythropterin
Authors: von Philipsborn W. , Stierlin H. , Traber W. 
Published: December 2004

AbstractProton magnetic resonance spectra of 9‐acetonylxanthopterine (I) and erythropterine (II) are reported. Based upon these data and UV.‐spectroscopic evidence, it is shown that these compounds exist in the tautomeric forms Ib and IIb, respectively.
Über Pterinchemie. 8. Mitteilung. Struktur und Protonenresonanz‐Spektren einiger Xanthopterinderivate
Authors: Merlini L. , von Philipsborn W. , Viscontini M. 
Published: December 2004

AbstractIm Zusammenhang mit der Struktur des Schmetterlingspigmentes Erythropterin wurden einige Xanthopterinderivate untersucht und die Tautomeriefragen mittels NMR.‐ und UV.‐Spektren abgeklärt.
Etude des composés d'addition des acides de LEWIS XIX. Sur les composés formés par les 2‐ et 4‐hydroxyacétophénones avec TiCl4 et ZnCl2
Authors: Göhring J. , Rossetti G. P. , Susz B. P. 
Published: December 2004

AbstractThe preparation of complex compounds between ZnCl2 or TiCl4 and p‐hydroxy‐, o‐hydroxy‐ and hydroxy‐2‐methyl‐5‐acetophenone is described. Some of these compounds have been isolated as intermediate complexes of Fries rearrangements catalyzed by TiCl4. ZnCl2 forms addition compounds whereas with TiCl4 elimination of HCl occurs. The IR, absorption spectra are examined and prodable structures proposed for the compounds. The electronic acceptor group ‐OTiCl2 is found to be weaker than TiCl4 and about as strong ZnCl2 when dative bonds are formed.
Ringschlussreaktionen des Butadiendioxids mit Hydrazinen zu neuen Derivaten des Pyrazolidins und Piperidazins
Authors: Meyer H. R. , Gabler R. 
Published: December 2004

AbstractThe reaction of butadiene dioxide (dl‐and meso‐) with various hydrazines led to 1: 1‐adducts having either pyrazolidine or piperidazine structures. Using N,N′‐di‐substituted hydrazines, pyrazolidine derivatives were obtained with yields of 70–80%, whereas hydrazine itself reacted with DL‐butadiene dioxide to give about 20% of trans‐4,5‐dihydroxypiperidazine and a small quantity of trans‐7,8‐tetrahydroxy‐10‐azaquinolizidine. The five ring closure reaction seems to be a general and preparativeloy interesting pyrazolidine synthesis. The structure of a representative of the 5‐ and of the 6‐ring system was proven by their conversion into open chain diamines. The constitutions of these diamines were established by independent synthesis or by conversion into known compounds. The assignation of the other 1: 1‐adducts to the pyrazolidine or to the piperidzaien series respectively was carried out by mean of NMR‐analysis.
Hircinol, eine antifungisch wirksame Substanz aus Knollen von Loroglossum hircinum (L.) RICH
Authors: Urech J. , Fechtig B. , Nüesch J. , Vischer E. 
Published: December 2004

AbstractAus Knollen von Loroglossum hircinum (L.) Rich., welche mit dem Pilz Rhizoctonia versicolor Müller et Nüesch infiziert worden sind, wird das fungistatisch wirksame Hircinol, C15H14O3, in Ausbeuten von 250–400 mg pro kg Knollengewebe isoliert. Die Knollen enthalten ferner pro kg ca. 150 mg einer fungistatisch unwirksamen Substanz A. Beide Verbindungen scheinen dem Orchinol, einem aus Orchis militaris L. isolierten Pilzabwerhrstoff, chemisch nahe zu stehen. Substanz A hat sich als identisch mit dem von Hardegger und Mitarb. beschirebene Loroglossol erwiesen.
Synthesen in der Polymyxin‐Reihe. 8. Mitteilung. Synthese des hochaktiven cyclischen Decapeptides 7 γ und sein Vergleich mit natürlichem Polymyxin B1
Authors: Vogler K. , Studer R. O. , Lanz P. , Lergier W. , Böhni E. , Fust B. 
Published: December 2004

AbstractEs wird über die Synthese des cyclo‐Decapeptides 7γ berichtet. Als Ergebnis unserer Bemühungen zur Strukturaufklärung von Polymyxin B2 durch Synthese wird festgestellt, dass keine der möglichen Formeln 8α, 8γ, 7α und 7γ, die durch Abbau hergeleitet wurden, mit der Struktur von Polymyxin B1 übereinstimmen, obwohl 7α und 7γ eine bemerkenswerte antimikrobielle Aktivität in vitro in vivo aufweisen.
Reaktionen von Steroid‐Hypojoditen VII. 3‐Oxo‐1,11α‐oxido‐Δ1‐steroide. Über Steroide, 204. Mitteilung
Authors: Meystre Ch. , Kalvoda J. , Anner G. , Wettstein A. 
Published: December 2004

AbstractThe homolytic cleavage of 11‐hypoiodites of 3‐oxo‐11α‐hydroxy‐steroids, generated from the corresponding hydroxy compounds by treatment with lead tetraacetate and iodine, has been investigated. The main reaction products are enol ethers containing the 3‐oxo‐1, 11α‐oxido‐Δ1‐grouping.
Über eine neuartige Basen‐katalysierte Umlagerung der Nitroso‐Gruppe
Authors: Daeniker H. U. 
Published: December 2004

AbstractBy treatment with bases in methanolic solution N‐substituted N‐nitroso‐amino‐acetonitriles (I) undergo an internal rearrangement of the nitroso group to yield α‐isonitroso‐aminoacetonitriles (II). The structures of the rearrangement products are proved by their physico‐chemical properties, by chemical degradation to known products, and by transformation into a number of derivatives. Similar compounds in which the nitrile group of I is replaced by other activating groups do not rearrange to compounds analogous to 11, but lead in part to SCHIFF bases. Mechanisms for all these reactions are proposed.