bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to follow the guidelines, when the appropriate fluid is missing?
Authors: Brossier David W. , Goyer Isabelle , Morice Claire , Alsohime Fahad , Mayberry Huw F. , Porcheret Florence , Tume Lyvonne N. , Valla Frederic V. , group (ESPNIC) IV-MFT 
Published: February 2024

Abstract
Intravenous maintenance fluid therapy (IV-MFT) is probably the most prescribed drug in paediatric hospital care. Recently paediatric societies have produced evidence-based practice guidelines that recommend the use of balanced isotonic fluid when prescribing IV-MFT in both acute and critical paediatric care. Unfortunately, the applicability of these guidelines could be called into question when a ready-to-use glucose containing balanced isotonic fluid is not available. The main objective of this study was to describe the availability of glucose containing balanced isotonic fluids in European and Middle Eastern paediatric acute and critical care settings. This work is an ancillary study of the survey dedicated to IV-MFT practices in the paediatric acute and critical care settings in Europe and Middle East, a cross-sectional electronic 27-item survey, emailed in April–May 2021 to paediatric critical care physicians across 34 European and Middle East countries. The survey was developed by an expert multi-professional panel within the European Society of Peadiatric and Neonatal Intensive Care (ESPNIC). Balanced Isotonic Fluid with glucose 5% was available for only 32/153 (21%) responders. Balanced Isotonic Fluid with glucose 5% was consistently available in the United Kingdom (90%) but not available in France, Greece, The Netherlands and Turkey. Ready-to-use isotonic balanced IV solutions containing glucose in sufficient amount exist, but are inconsistently available through Europe. National and European Medication Safety Incentives should guarantee availability of the most appropriate and safest IV-MFT solution for all children.
A novel nomogram predicting short-term overall survival of patients with glioma
Authors: Yang Xing-jie , Xi Jian-hua , Sun Nai-ying , Bao Jin , Ma Qiang 
Published: February 2024

Abstract

Gliomas are the most common malignant tumors in the central nervous system. This study aimed to create a tumor survival prediction model to predict short-term overall survival in patients with glioma. In this study, the mRNAseq_325 dataset was downloaded from the Chinese Glioma Genome Atlas database as the training group, and the mRNAseq_693 dataset was downloaded as the validation group. LASSO‐COX algorithm was applied to shrink predictive factor size and build a risk score. The calibration curves and C‐Index were assessed to evaluate the nomogram's performance. This study found that the risk score, built by the LASSO‐COX algorithm, was significantly associated with overall survival in gliomas, and the nomogram, combining the risk score and clinical prognostic predictors, showed powerful prognostic ability in the training and validation groups. In conclusion, an individualized prediction model was established for predicting the short-term overall survival of glioma patients, which can provide valuable insights into identifying individuals at high risk and highlight the potential in facilitating early interventions and accurate treatment for patients with limited survival prognosis.
Loggerhead Sea Turtles as Hosts of Diverse Bacterial and Fungal Communities
Authors: Filek Klara , Vuković Borna Branimir , Žižek Marta , Kanjer Lucija , Trotta Adriana , Bello Antonio di , Corrente Marialaura , Bosak Sunčica 
Published: February 2024

Abstract

The research on microbial communities associated with wild animals provides a valuable reservoir of knowledge that could be used for enhancing their rehabilitation and conservation. The loggerhead sea turtle (Caretta caretta), a globally distributed species, currently has a thriving population in the Mediterranean Sea, thanks to robust conservation efforts. In our study we aimed to further understand their biology in relation to their associated microorganisms. We investigated epi- and endozoic bacterial and endozoic fungal communities of cloaca, oral mucosa, carapace biofilm samples obtained from 18 juvenile, subadult and adult turtles as well as 8 respective enclosures, during a period of 3 years, by amplicon sequencing of 16S rRNA gene and ITS2 region of nuclear ribosomal gene. Our results reveal a trend of decreasing diversity of distal gut bacterial communities with the age of turtles. Notably, Tenacibaculum species show higher relative abundance in juveniles than in adults. Differential abundances of taxa identified as Tenacibaculum, Moraxellaceae, Cardiobacteriaceae, and Campylobacterwere observed in both cloacal and oral samples in addition to having distinct microbial compositions with Halioglobus taxa present only in oral samples. Fungal communities in loggerheads' cloaca were diverse and varied significantly among individuals, differing from those of tank water. Our findings expand the known microbial diversity repertoire of loggerheads, highlighting interesting taxa specific to individual body sites. This study provides a comprehensive view of the loggerhead sea turtle bacterial microbiota and marks the first report of distal gut fungal communities that contributes to establishing a baseline understanding of loggerhead sea turtle holobiont.
Expression, Prognostic and Immunological Roles of USP8 in kidney renal clear cell carcinoma: An Integrated Analysis
Authors: Yan Wen , Yue Zeng , Qiying Zeng , Wubing Feng , Yan Chen , Xi Yao , Can Wang 
Published: February 2024

Abstract
Background
USP8 is a deubiquitinating enzymes (DUBs) that belongs to the ubiquitin-specific processing (USP) protease family. Previous study revealed that USP8 overexpressed and acted as oncogenes in multiple cancers. However, the function of USP8 in kidney renal clear cell carcinoma (KIRC) remains unclear. This research aimed to investigate USP8 expression, prognostic value and its possible roles in tumor immunity in KIRC.
Methods
Data on patients diagnosed with KIRC were extracted from the TCGA-KIRC and other public omics databases. We detected the expression profiles, clinical relevance and diagnostic value of USP8 in KIRC using GEPIA, UALCAN, GTEx, TIMER, Kaplan-Meier Plotter and HPA Database. The epigenetic characteristics of USP8 were detected by UALCAN and DNMIVD Database. Co-expressed with USP8 and related mechanism analyses were conducted by retrieving data in STRING and cBioPortal. In addition, immune infiltration, single-cell expression and immunotherapy-related analyses were performed by TIMER and TISCH2.
Results
Low expression levels of USP8 were observed in most cancer types. USP8 mRNA and proteins were downregulated in KIRC. Detection of epigenetics and genetics of USP8 suggested that its expression was negatively related to DNA methylation. Higher-expressed USP8 patients had a better prognosis, including overall survival (OS) and disease free survival (DFS). USP8 mRNA was aberrantly downregulated and correlated to sample types, tumor grade, stages, subtypes and nodal status. Immune infiltration and single-cell analysis suggested the indispensable role of USP8 expression in immune cell infiltration, indicating that USP8 may be an underlying predictor of immune treatment effects for KIRC patients. Meanwhile, the USP8-related gene expression signature in KIRC is correlated to the enrichment of genes involved in the ErbB signaling pathway, Ubiquitin mediated proteolysis, EGFR tyrosine kinase inhibitor resistance, etc.
Conclusions
Methylated USP8 may act as a novel prognostic and immunotherapy biomarker for KIRC.
A tentative role of vibration-based communication in locust collective behavior
Authors: Pinchasik Bat-El , Das Rakesh , David Izhak , Ayali Amir 
Published: February 2024

Abstract
Locusts are renowned for their coordinated locomotion, in which juveniles swarm and walk in a synchronized fashion. While it is generally accepted that vision is the main form of communication enabling this behavior, it is suggested here that mechanical vibrations may also contribute to communication within the group. Using a laser Doppler vibrometer and accelerometer, the substrate vibration signals generated by locust walking, jumping, and coordinated marching were quantified in terms of frequency and amplitude. These mechanical signals were then artificially produced by a vibration generator and directly applied to the mechanical sensory receptors of experimental tethered locusts. A sensory threshold curve of the mechanical response of the locusts was established, in order to quantify and compare their ability to sense specific forms of locomotion. While the vibrations generated by individuals walking in an unsynchronized fashion were below the sensory threshold of the locust, our findings indicate that locusts are capable of sensing the vibration signals generated by locust hopping or by the collective marching of conspecifics. It is suggested that locusts in a swarm may use substrate-borne mechanical vibrations for communication within the group, and that vibration-based communication may have a role in locust collective behavior and coordinated marching.
Lymphocytopenia is a main sensitive risk factor of primary liver cancer complicated with bacterial infections
Authors: Ye Wenyi , Zhao Hong , Guo Yong 
Published: February 2024

Abstract
As we known immunity and inflammation play an important role in primary liver cancer (PLC) development. Through retrospective analysis of patients with or with PLC in our center in order to analyze the clinical features of circulating cytokines, immunoglobulin, complement and leukocyte subsets in patients with primary liver cancer (PLC) with or without bacterial infections (BIs). Propensity score matching (PSM) to adjust differences in baseline characteristics. The possible confounding risk factors for PLC-BIs during hospitalization were been explored by multivariate logistic regression model analysis and area under the ROC curve (AUC) to analyze the sensitivity and specificity of the risk factors of hepatitis B patients with PLC-BIs. 225 patients with chronic B hepatitis in hospitalization were been enrolled. After PSM, patients with PLC were higher incidence of BIs (25.0% vs. zero, p = 0.004) and lower lymphocytes count and subsets (p < 0.001) whether or not with BIs. The percentage of lymphocytes [Odds ratio (OR) = 0.82, 95% confidence interval (CI): 0.73–0.93, p = 0.002] was the independent risk factors for patients with PLC-BIs. The AUC of the percentage of lymphocytes was 0.806 (95%CI: 0.71–0.88, p < 0.0001), the sensitivity was 82.4% and specificity was 83.6% when the levels of the levels of percentage of lymphocytes lower 15.9%. We may safely concluded that patients with PLC decreased immunity and increased some inflammatory cytokines, were easy to merge BIs. Furthermore, lymphocytopenia is the main risk factor of PLC complicated with BIs.
Destruction mechanism and control technology of peripheral rock of shallowly buried large mining height roadway under concentrated coal pillar
Authors: Yun Qinglong , Zhang Wenbo , Liu Tao , Wang Jianghao , Tong Fei 
Published: February 2024

Abstract
To study the damage mechanism of the return roadway of shallow burial depth, thin bedrock, and large mining height working face under the action of concentrated coal pillar. In this paper, we take the 22408 return roadway of Bulianta Mine as the research background and focus on the problem that the mine pressure appears drastically when it passes over the overlying concentrated coal pillar. Through theoretical analysis and numerical simulation, the mine pressure manifestation law of 22408 working face back to the mining roadway is studied. We analyzed the reasons that led to the drastic manifestation of mine pressure in the 22408 return roadway over the overlying concentrated coal pillar, revealed the damage mechanism of the roadway under this condition, and put forward a reasonable and effective method of controlling the stability of the surrounding rock for this problem. (1) Propose to utilize hydraulic fracturing to control the problem in advance, and set up a drilling field in the 22407 return tunnel to fracture the medium-grained sandstone 20m above the 2–2 coal in advance; (2) Strengthen the support of the area affected by the coal pillar in advance, and replenish three Φ21.6×8150 mm anchor cables with the spacing of 1200 mm-1500 mm-1500 mm-1200 mm on the roof of the tunnel; (3) Strengthen the support of the area affected by the coal pillar in advance; (4) Strengthen the support of the area affected by the coal pillar in advance, and strengthen the support of the area affected by the coal pillar in advance. At this time, three Φ21.6×5150 mm anchor cables with PVC belts were installed on the side gang of the return tunnel, and the optimized return tunnel was monitored on site, and the effect was good.
Overnight Stay in Spanish Emergency Departments and Mortality in Older Patients
Authors: Miró Òscar , Aguiló Sira , Alquézar-Arbé Aitor , Fernandez Cesáreo , Burillo Guillermo , Martínez Sergio Guzmán , Larrull Maria Esther Martínez , Periago Andrea B. Bravo , Molinas Claudia Lorena Amarilla , Falcon Carolina Rangel , Dacosta Paz Balado , Flores Rudiger Carlos Chávez , Calzada Jorge Navarro , Blesa Eva Maria Fragero , Martín Manuel Ángel Palomero , Requena Ángela Cobos , Fuentes Lidia , Cortizo Isabel Lobo , Garcinuño Pablo Gonzalez , García María Bóveda , Valle Pedro Rivas Del , Campos Raquel Benavent , Jiménez Verónica Castro , Cuñado Vanesa Abad , Gutiérrez Olga Trejo , Reviriego María del Mar Sousa , Roussel Melanie , Castillo Juan González Del 
Published: February 2024

Abstract

OBJECTIVE: To assess whether older adults who spend a night in emergency departments (ED) awaiting admission are at increased risk of mortality.
METHODS: This was a retrospective review of a multipurpose cohort that recruited all patients ≥75 years who visited ED and were admitted to hospital on April 1 to 7, 2019, at 52 EDs across Spain. Study groups were: patients staying in ED from midnight until 8:00 a.m. (ED group) and patients admitted to a ward before midnight (ward group). The primary endpoint was in-hospital mortality, truncated at 30 days, and secondary outcomes assessed length of stay for the index episode.
RESULTS: The sample comprised 3,243 patients (median [IQR] age, 85 [81-90] years; 53% women), with 1,096 (34%) in the ED group and 2,147 (66%) in the ward group. In-hospital mortality in ED vs ward group was 10.7% vs 9.5% (adjusted OR: 1.12, 95%CI: 0.80-1.58). Sensitivity analyses rendered similar results (ORs ranged 1.06-1.13). Interaction was only detected for academic/non-academic hospitals (p<0.001), with increased mortality risk for the latter (1.01, 0.33-3.09 vs 2.86, 1.30-6.28). There were no differences in prolonged hospitalization (>7 days), with adjusted OR of 1.16 (0.94-1.43) and 1.15 (0.94-1.42) depending on whether time spent in the ED was or was not taken into consideration.
CONCLUSIONS: No increased risk of in-hospital mortality or prolonged hospitalization was found in older patients waiting overnight in the ED for admission. Nonetheless, all estimations suggest a potential harmful effect of staying overnight, especially without the proper hospitalist care.
Seizure outcomes and predictors in patients with repeat epilepsy surgery
Authors: Hu Yue , Chen Guoqiang , Liu Yaoling , Zhang Rui , Chen Jianwei , Zhou Junjian , Zhang Zhaozhao , Hu Jianfei , Liu Qiang , Zhang Guangming 
Published: February 2024

Abstract
(1) Background: One of the most important goals of surgical epilepsy treatment is seizure freedom. Patients who continue to experience seizures after epilepsy surgery could be considered for a repeat surgical treatment. This study aimed to analyze the seizure outcomes of re-peat surgical treatment of epilepsy and evaluate the prognostic factors.
(2) Methods: This single-center cohort study retrospectively collected clinical data from patients undergoing repeat epilepsy surgery at the Aviation General Hospital from 2016 to 2022. Patients who met the inclusion criteria were followed up for at least one year, and seizure outcomes were based on the International League Against Epilepsy (ILAE) seizure outcome classification.
(3) Results: A total of 43 patients were included in this study, with a mean follow-up of 43.95 months. Malformation of cortical development was the most common postoperative pathology finding, occurring in 19 (44.2%) patients, followed by tumors in seven (16.3%) patients. Following repeat epilepsy surgery, 23 (53.5%) patients achieved ILAE Class 1 or 2. Multifactorial analysis showed that lesional magnetic resonance imaging (MRI) was associated with favorable seizure outcomes, and bilateral or multifocal ictal discharge patterns predicted poor seizure outcomes. Repeat epilepsy surgeries resulted in 13 (30.2%) patients with permanent neurological deficits.
(4) Conclusions: Following a detailed assessment, including imaging, electroencephalography (EEG), and invasive evaluation, repeat epilepsy surgery is a safe and effective option for patients who have failed resective epilepsy surgery. Meanwhile, possible neurological permanent deficits should be taken into account when considering repeat surgery.
The role of water and iodine in supramolecular assembly of a 2D coordination of benzimidazole derivate: X-ray crystallography and DFT calculations
Authors: Gandhi Sahaj A. , Soni Saurabh S. , Patel Urmila H. , Kotadia Deepali 
Published: February 2024

Abstract
We describe the synthesis and crystal structure of DBZIW, 1,3-Dimethyl-3H-benzimidazol-1-ium iodide monohydrate, which crystallizes in a monoclinic system with space group P21/c and Z = 4. The asymmetric unit contains a molecule of [C9 H11N2]+, an iodine ion I−, and a water molecule. Water oxygen O1 and iodine ion I− (O-H...I) connection display significant involvement in hydrogen bond interactions in the molecular packing of DBZIW. The network of C-H...O hydrogen bond contacts plays an essential part in the stability. The molecular structures 1, 3-Dimethyl-3H-benzimidazol-1-ium [DBZ], 1, 3-Dimethyl-3H-benzimidazol-1-ium, monohydrate [DBZW], 1, 3-Dimethyl-3H-benzimidazol-1-ium, iodine [DBZI] and 1, 3-dimethyl-3H-benzimidazol-1-ium iodide monohydrate [DBZIW] were optimized at the B3LYP method with 6-311G (d, p) level using Gaussain-09 software. The energy band gap value of HOMO and LUMO of DBZ, DBZW, DBZI and DBZIW have 4.997 eV, 4.786 eV, 3.309 eV and 1.265 eV, respectively. The HOMO-LUMO energy gap, which is useful in determining the molecular electrical transport properties, explains the charge transfer interaction inside the molecule. The molecular docking studies indicated that DBZIW had high binding affinity for thyroid stimulating hormone receptor (TSHR) protein targets (4QT5).
The impact of betrayal-based moral injury on PTSD and depression in the aftermath of the October 7th 2023 terror attack in Israel: A nationwide prospective study
Authors: Levi-Belz Yossi , Blank Carmel , Groweiss Yoav , Neria Yuval 
Published: February 2024

Abstract

With more than 1300 civilians murdered and 240 civilians kidnapped, the massacre of October 7th is one of the deadliest terrorist attacks in modern history. The mental health consequences of terrorist attacks have been documented. However, little is known of the impact of betrayal-based moral injury (MI)––in which individuals feel betrayed by leaders they once trusted–– on levels of psychological burden in the aftermath of such an attack. In this national prospective cohort study, we examined to what extent the experience of betrayal exacerbates the risk for posttraumatic stress disorder (PTSD) and depression in the wake of the October 7th terrorist attack. A representative sample of 710 Israeli adults (362 female, 51.1%), Jews (557, 79.9%) and Arabs (153, 20.1%), aged 18–85 (M = 41.01, SD = 13.72) completed validated self-report questionnaires assessing PTSD, depression, and betrayal-related MI at two timepoints: T1, in August 2023 (6–7 weeks before the attack) and T2, in November 2023 (5–6 weeks after the attack). In two hierarchical logistic regressions, we found that experience of betrayal predicted diagnoses of both PTSD (OR = 1.75, 95% CI = 1.18–2.60) and depression (OR = 2.01, 95% CI = 1.35–2.91) at T2, beyond probable PTSD/depression at T1 and demographic and trauma-related variables. Moreover, in two repeated-measure analyses predicting PTSD/depression symptoms, we found significant interactions between PTSD/depression trajectories and betrayal, meaning that the increase of PTSD/depression symptoms was significantly higher among participants experiencing betrayal by leaders in the context of the attack. Our study highlights the impact of betrayal-based MI on the dramatic increase in psychopathology following the October 7th terror attack in Israel’s population. Clinicians treating individuals coping with PTSD and depression should attend to their patients’ possible exposure to betrayal-based MI following the attack. Moreover, national leaders and policymakers should take significant steps to repair the public’s betrayal experience.
Co-pyrolysis Development of Waste Tire-sludge Adsorbent by Mixed of Waste Tires and Oily Sludge
Authors: Tang Chao , Guan Jiaojiao , Xie Shui-xiang 
Published: February 2024

Abstract

To facilitate resource utilization of waste tires (WT) and oily sludge (OS), waste tire-sludge adsorbent (WTSA) was developed using co-pyrolysis technology, and its effectiveness in adsorbing crude oil was investigated. The study revealed that the optimal preparation conditions for WTSA included a 1.5:1 mass ratio of WT to OS, a co-pyrolysis temperature of 600 ℃, a co-pyrolysis holding time of 2 hours, and a co-pyrolysis heating rate of 15 ℃/min. The surface of WTSA exhibited numerous pores and cracks with varying shapes and sizes. The dominant pore structures were found to be mesopores and macropores. The carbon content of WTSA was measured to be 89.95%. Moreover, the BET specific surface area, pore volume, and average pore size were determined to be 686.81 m2/g, 0.74 cm3/g, and 5.91 nm, respectively. In the crude oil adsorption test, WTSA demonstrated a comparable adsorption capacity to activated carbon (AC), but with a more attractive initial adsorption rate. Furthermore, thermal regeneration treatment was found to significantly enhance the lipophilic properties of WTSA, leading to an increase in its initial adsorption rate. The adsorption capacity of regenerated WTSA was also found to be relatively stable, making it an ideal solution for emergency crude oil spill cleanups. Compared to AC, WTSA can be recycled and reused multiple times, making it a more sustainable and cost-effective option.