bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aesthetic Motivation Impacts Judgments of Others’ Prosociality and Mental Life
Authors: Agrawal Tanushree , Schachner Adena 
Published: December 2023

Abstract
The ability to infer others’ prosocial vs. antisocial behavioral tendencies from minimal information is core to social reasoning. Aesthetic motivation (the value or appreciation of aesthetic beauty) is linked with prosocial tendencies, raising the question of whether this factor is used in interpersonal reasoning and in the attribution of mental capacities. We propose and test a model of this reasoning, predicting that evidence of others’ aesthetic motivations should impact judgments of others’ prosocial (and antisocial) tendencies by signaling a heightened capacity for emotional experience. In a series of four pre-registered experiments (total N = 1440), participants saw pairs of characters (as photos/vignettes), and judged which in each pair showed more of a mental capacity of interest. Distractor items prevented participants from guessing the hypothesis. For one critical pair of characters, both characters performed the same activity (music listening, painting, cooking, exercising, being in nature, doing math), but one was motivated by the activities’ aesthetic value, and the other by its functional value. Across all activities, participants robustly chose aesthetically-motivated characters as more likely to behave compassionately (Exp. 1; 3), less likely to behave selfishly/manipulatively (Exp. 1; 3), and as more emotionally sensitive, but not more intelligent (Exp. 2; 3; 4). Emotional sensitivity best predicted compassionate behavior judgements (Exp. 3). Aesthetically-motivated characters were not reliably chosen as more helpful; intelligence best predicted helpfulness judgements (Exp. 4). Evidence of aesthetic motivation conveys important social information about others, impacting fundamental interpersonal judgments about others’ mental life and social behavior.
Optimum Estimation of Coastal Currents Using Moving Vehicles
Authors: Chen KuanYu , Huang Chen-Fen , Zheng Zhe-Wen , Lin Sheng-Fong , Liu Jin-Yuan , Guo Jenhwa 
Published: December 2023

Abstract
Ocean acoustic tomography (OAT) deploys most moored stations on the periphery of the tomographic region to sense the solenoidal current field. Moving vehicle tomography (MVT), an advancement of OAT, not only samples the region from various angles for improving the resolution of mapped currents but also acquires information about the irrotational flow due to the sampling points inside the region. To reconstruct a complete two-dimensional current field, the spatial modes derived from the open-boundary modal analysis (OMA) are preferable to the conventional truncated Fourier series since the OMA technique describes the solenoidal and irrotational flows efficiently in which all modes satisfy the coastline and open boundary conditions. Comparisons of the reconstructions are presented using three different representations of currents. The first two representations explain only the solenoidal flow: the truncated Fourier series and the OMA Dirichlet modes. The third representation, accounting for the solenoidal and irrotational flows, uses all the OMA modes. For reconstructing the solenoidal flow, the OMA representation with the Dirichlet modes performs better than the Fourier series. A large difference appears near the bay mouth, where the OMA-Dirichlet reconstruction shows a better fit to the uniform currents. However, considerable uncertainty exists outside the bay mouth where the irrotational currents dominate. This can be improved by the third representation with the inclusion of the Neumann and boundary modes. The reconstruction results using field data were validated against the acoustic Doppler current profiler (ADCP) measurements. Additionally, incorporating constraints from ADCP measurements enhances the accuracy of the reconstruction.

Significance Statement
This study contributes toward improving our understanding of accurately measuring oceanic circulation patterns over large areas without relying solely upon stationary sensors or satellite imagery. The study combines multiple sources, such as shipboard ADCP and tomographic techniques, to obtain a complete picture of what is happening beneath surface waters across entire regions under investigation. It has important implications for fields such as climate science, marine biology, and fisheries management, where accurate knowledge of the movement and distribution of water masses is crucial for predicting future trends and making informed decisions.
Urinary metabolite of pesticide, 3,5,6-trichloropyridinol, is associated with all-cause but not with cancer mortality
Authors: Qiao Fulu , Ma Teng , Wang Xia , Zhang Feng , Wan Long 
Published: December 2023

Abstract3,5,6-trichloropyridinol (TCPY) is a metabolite of chlorpyrifos and chlorpyrifos-methyl, whose presence in the environment is of potential toxicity to human. So, it is need to monitor and regualte TCPY levels to protect human health. However, it is not known whether TCPY is associated with all-cause and cancer mortality and to which degree its levels contributed to hazard risk. The study enrolled 3951 participants from the National Health and Nutrition Examination Surveys (NHANES). Ultra-high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry was used to measure urinary TCPY. Cox proportional hazards regression analysis was performed to explore the associations between TCPY and all-cause and cancer mortality. The study found that the average level of TCPY in the cohort was 1.79 μg/L and was higher in those who had passed away. Individuals in the highest quartile had a 1.56-fold independent increase in rate for all-cause mortality compared to those in the lowest quartile (hazard ratio [HR] 1.56, 95% confidence interval 1.09–2.24, p = 0.002). However, while the univariate model showed a hazard ratio of 2.37 (1.19–4.71) for the highest quartile in regards to cancer mortality, this association disappeared after adjusting for demographics, lifestyles, and comorbidities. Exposure to urinary 3,5,6-trichloropyridinol, as a result of insecticide exposure, increased the rate of all-cause mortality but was not independently associated with cancer mortality.
Transcriptomic analysis reveals the early body wall regeneration mechanism of the sea cucumber Holothuria leucospilota after artificially induced transverse fission
Authors: Liu Renhui , Ren Xinyue , Wang Junyan , Chen Ting , Sun Xinyu , Lin Tiehao , Huang Jiasheng , Guo Zhengyan , Luo Ling , Ren Chunhua , Luo Peng , Hu Chaoqun , Cao Xudong , Yan Aifen , Yuan Lihong 
Published: December 2023

Abstract
Background
Sea cucumbers exhibit a remarkable ability to regenerate damaged or lost tissues and organs, making them an outstanding model system for investigating processes and mechanisms of regeneration. They can also reproduce asexually by transverse fission, whereby the anterior and posterior bodies can regenerate independently. Despite the recent focus on intestinal regeneration, the molecular mechanisms underlying body wall regeneration in sea cucumbers still remain unclear.

Results
In this study, transverse fission was induced in the tropical sea cucumber, Holothuria leucospilota, through constrainment using rubber bands. Histological examination revealed the degradation and loosening of collagen fibers on day-3, followed by increased density but disorganization of the connective tissue on day-7 of regeneration. An Illumina transcriptome analysis was performed on the H. leucospilota at 0-, 3- and 7-days after artificially induced fission. The differential expression genes were classified and enriched by GO terms and KEGG database, respectively. An upregulation of genes associated with extracellular matrix remodeling was observed, while a downregulation of pluripotency factors Myc, Klf2 and Oct1 was detected, although Sox2 showed an upregulation in expression. In addition, this study also identified progressively declining expression of transcription factors in the Wnt, Hippo, TGF-β, and MAPK signaling pathways. Moreover, changes in genes related to development, stress response, apoptosis, and cytoskeleton formation were observed. The localization of the related genes was further confirmed through in situ hybridization.

Conclusion
The early regeneration of H. leucospilota body wall is associated with the degradation and subsequent reconstruction of the extracellular matrix. Pluripotency factors participate in the regenerative process. Multiple transcription factors involved in regulating cell proliferation were found to be gradually downregulated, indicating reduced cell proliferation. Moreover, genes related to development, stress response, apoptosis, and cell cytoskeleton formation were also involved in this process. Overall, this study provides new insights into the mechanisms of whole-body regeneration and uncover potential cross-species regenerative-related genes.
Targeting antimalarial metabolites from the actinomycetes associated with the Red Sea sponge Callyspongia siphonella using a metabolomic method
Authors: Gamaleldin Noha M. , Bahr Hebatallah S. , Millán-Aguiñaga Natalie , Danesh Mahshid , Othman Eman M. , Dandekar Thomas , Hassan Hossam M. , Abdelmohsen Usama Ramadan 
Published: December 2023

AbstractMalaria is a persistent illness that is still a public health issue. On the other hand, marine organisms are considered a rich source of anti‑infective drugs and other medically significant compounds. Herein, we reported the isolation of the actinomycete associated with the Red Sea sponge Callyspongia siphonella. Using "one strain many compounds" (OSMAC) approach, a suitable strain was identified and then sub-cultured in three different media (M1, ISP2 and OLIGO). The extracts were evaluated for their in-vitro antimalarial activity against Plasmodium falciparum strain and subsequently analyzed by Liquid chromatography coupled with high-resolution mass spectrometry (LC-HR-MS). In addition, MetaboAnalyst 5.0 was used to statistically analyze the LC-MS data. Finally, Molecular docking was carried out for the dereplicated metabolites against lysyl-tRNA synthetase (PfKRS1). The phylogenetic study of the 16S rRNA sequence of the actinomycete isolate revealed its affiliation to Streptomyces genus. Antimalarial screening revealed that ISP2 media is the most active against Plasmodium falciparum strain. Based on LC-HR-MS based metabolomics and multivariate analyses, the static cultures of the media, ISP2 (ISP2-S) and M1 (M1-S), are the optimal media for metabolites production. OPLS-DA suggested that quinone derivatives are abundant in the extracts with the highest antimalarial activity. Fifteen compounds were identified where eight of these metabolites were correlated to the observed antimalarial activity of the active extracts. According to molecular docking experiments, saframycin Y3 and juglomycin E showed the greatest binding energy scores (-6.2 and -5.13) to lysyl-tRNA synthetase (PfKRS1), respectively. Using metabolomics and molecular docking investigation, the quinones, saframycin Y3 (5) and juglomycin E (1) were identified as promising antimalarial therapeutic candidates. Our approach can be used as a first evaluation stage in natural product drug development, facilitating the separation of chosen metabolites, particularly biologically active ones.
Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders
Authors: Palamarchuk Iryna S. , Slavich George M. , Vaillancourt Tracy , Rajji Tarek K. 
Published: December 2023

AbstractIn this narrative review, we examine biological processes linking psychological stress and cognition, with a focus on how psychological stress can activate multiple neurobiological mechanisms that drive cognitive decline and behavioral change. First, we describe the general neurobiology of the stress response to define neurocognitive stress reactivity. Second, we review aspects of epigenetic regulation, synaptic transmission, sex hormones, photoperiodic plasticity, and psychoneuroimmunological processes that can contribute to cognitive decline and neuropsychiatric conditions. Third, we explain mechanistic processes linking the stress response and neuropathology. Fourth, we discuss molecular nuances such as an interplay between kinases and proteins, as well as differential role of sex hormones, that can increase vulnerability to cognitive and emotional dysregulation following stress. Finally, we explicate several testable hypotheses for stress, neurocognitive, and neuropsychiatric research. Together, this work highlights how stress processes alter neurophysiology on multiple levels to increase individuals’ risk for neurocognitive and psychiatric disorders, and points toward novel therapeutic targets for mitigating these effects. The resulting models can thus advance dementia and mental health research, and translational neuroscience, with an eye toward clinical application in cognitive and behavioral neurology, and psychiatry.
The creation and validation of predictive models to assess the risk of unfavorable outcomes following hybrid total arch repair for Stanford type A aortic dissection
Authors: Liu Xinyi , Liu Xing , Yang Yuehang , Zhang Ai , Shi Jiawei , Li Huadong , Liu Junwei , Jiang Xionggang , Wang Zhiwen 
Published: December 2023

Abstract
Background
The objective of this study was to develop and validate a nomogram for the individualized prediction of adverse events in patients with Stanford type A aortic dissection (TAAD) undergoing hybrid total aortic arch repair.

Methods
From April 2019 to April 2022, we conducted a comprehensive review of the medical records of Stanford type A aortic dissection patients who underwent hybrid total aortic arch repair surgery at our hospital. Patients were separated into two groups based on whether or not a composite adverse event occurred following surgery. Using univariate and multivariate analyses of logistic regression, the prediction model was created. Construct risk prediction models utilizing nomograms and evaluate their precision, discrimination, and clinical utility.

Results
Age, platelets, serum blood urea nitrogen, and ascending aortic diameter were the variables included in the nomogram by univariate and multivariate analysis. The risk model performed well in internal validation, with an area under the curve (AUC) of 0.829. The calibration curve demonstrated good agreement between predicted and actual probabilities (Hosmer-Lemeshow test, P = 0.22). Clinical decision analysis curves demonstrate predictive nomograms’ clinical utility.

Conclusion
This study created and validated a nomogram for predicting the risk of composite endpoint events in TAAD patients undergoing hybrid total aortic arch repair. The nomogram can help determine the severity of a patient’s condition and provide a more personalized diagnosis and treatment.
Use of a combination of diaphragmatic ultrasound and muscle relaxation monitoring in predicting post-extubation adverse respiratory events among elderly patients in an anesthesia intensive care unit
Authors: Huang Lun , Xia Bo , Cheng Lei , Hu Xian-Wen , Zheng Li-Dong , Cheng Feng 
Published: December 2023

Abstract
Objective
The purpose of this study was to examine the feasibility of using a combination of diaphragmatic ultrasound and muscle relaxation monitoring in predicting adverse respiratory events after extubation among elderly patients in an anesthetic intensive care unit (AICU).

Methods
The study participants were 120 elderly patients who were in the AICU after laparoscopic radical resection for colorectal cancer. Based on whether there were critical respiratory events (CREs) after extubation, they were divided into the adverse event group and the non-adverse event group. We used logistic regression to identify factors influencing the occurrence of CREs post-extubation in elderly patients. Using the receiver operating characteristic (ROC) curve, we analyzed the value of each indicator in predicting CREs post-extubation.

Results
We included 109 patients in the final analysis. In the adverse event group (n = 19), the age, proportion of females, and proportion of preoperative respiratory diseases were higher than in the non-adverse event group (n = 90). The muscle relaxation value, quiet breathing diaphragmatic excursion during extubation (DE-QB), deep breathing diaphragmatic excursion during extubation (DE-DB), and deep breathing diaphragmatic thickening fraction during extubation (DTF-DB) of patients in the adverse event group were significantly lower than those in the non-adverse event group (P < 0.05). Using binary logistic regression analysis, we identified muscle relaxation value, DE-DB, and DTF-DB during extubation as significant predictors of CREs post-extubation in elderly patients (P < 0.05). The area under the curve (AUC) of the combination of the muscle relaxation value, DE-DB, and DTF-DB during extubation for predicting CREs after extubation in elderly patients was 0.949, which was higher than that of any single indicator.

Conclusion
The combination of diaphragmatic ultrasound and muscle relaxation monitoring was more accurate in predicting CREs post-extubation among elderly patients in the AICU.
“Salivary LINC00657 and miRNA-106a as diagnostic biomarkers for oral squamous cell carcinoma, an observational diagnostic study”
Authors: Tarrad Nayroz Abdel Fattah , Hassan Sandy , Shaker Olfat Gamil , AbdelKawy Maha 
Published: December 2023

Abstract
Background
Early detection and diagnosis of malignant tumors is critical for improving the survival rate and treatment outcomes of oral cancer. Thus, the current prospective investigation was designed to verify the role, sensitivity, and specificity of salivary LINC00657 and miRNA-106a as diagnostic markers in oral squamous cell carcinoma patients as compared to oral lichen planus (as an example of oral potentially malignant disorders) and normal individuals, and to show LINC00657 relation to miR-106a.

Methods
A total of 36 participants were included, subdivided into 3 groups: Group I: 12 patients diagnosed with oral squamous cell carcinoma (OSCC). Group II: 12 patients diagnosed with oral lichen planus (OLP). Group III: 12 systemically free individuals with no oral mucosal lesions. Unstimulated salivary samples were collected from all participants to evaluate level of LINC00657 and miR-106a in different groups using quantitative real-time PCR.

Results
OSCC showed the highest LINC00657 and lowest miR-106a fold change among included groups. Receiver Operating Characteristic (ROC) curve analysis of the two biomarkers for detecting OSCC revealed that LINC00657 had higher diagnostic accuracy (DA) (83.3%) compared to miR-106a (80.4%). As for detecting OLP, ROC analysis showed that miR-106a had higher (DA) (61%) compared to LINC00657 (52.5%). To discriminate OSCC from OLP, the diagnostic accuracy of both markers is the same (75%). Moreover, differentiating OSCC grades II and III, ROC analysis showed that miR-106a had lower (DA) (60%) compared to LINC00657 (DA) (83.3%).

Conclusions
Salivary LINC00657 and miR-106a could be promising diagnostic markers for oral squamous cell carcinoma. Salivary LINC00657 may differentiate oral squamous cell carcinoma from oral potentially malignant disorders with considerable diagnostic accuracy. Moreover, low levels of salivary miR-106a could have the potential to indicate malignancy.

Trial registration
The study was retrospectively registered on clinicaltrial.gov with NCT05821179 (first trial registration in 26/3/2023), date of registration: 19/4/2023.
The role of patients’ stories in medicine: a systematic scoping review
Authors: Quah Elaine Li Ying , Chua Keith Zi Yuan , Lin Casper Keegan Ronggui , Vijayan Andrew Vimal , Abdul Hamid Nur Amira Binte , Owyong Jasmine Lerk Juan , Satku Neeta , Woong Natalie , Lim Crystal , Phua Gillian Li Gek , Ong Eng Koon , Fong Warren , Krishna Lalit Kumar Radha 
Published: December 2023

Abstract
Background
Patients’ stories provide Palliative Care physicians with a glimpse into the former’s lives and their psycho-emotional, sociocultural, and contextual considerations. Yet, few physicians are trained to interpret and apply patients’ stories in their practice. Inherent variability in how stories are transmitted and interpreted raises questions over their potential effects on care. Amidst a dearth of accounts in Palliative Care, we map current use of patient stories to guide the training, assessment, and oversight of this ‘care influencing’ practice in medicine.

Methods
This systematic scoping review was guided by the Systematic Evidence-Based Approach (SEBA) to ensure a reproducible and structured approach. The themes and categories identified through the Split Approach’s concurrent and independent thematic and directed content analyses provided a comprehensive sketch of the included articles. The Jigsaw Perspective combined the themes and categories identified. The last stage of SEBA compared these results with two recent reviews of storytelling to ensure consistency of the domains created that guided the discussion.

Results
Ten thousand two hundred seven articles were reviewed, 963 full text articles were evaluated, and 199 articles were included. The four domains identified were study characteristics, benefits, approaches, and positive effects and concerns.

Conclusion
Stories support patient-centered, personalized, and holistic clinical care. However, variability in the stories, their interpretations and use in care decisions underscore the need for further study on the structuring, teaching, assessing, and delivery of this ‘care influencing’ practice.