bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unilateral lesion of the suprachiasmatic nucleus impairs estradiol feedback, follicular development, estrous cycle and ovulation
Authors: Silva Carlos-Camilo , Benítez Diana Pamela , Flores Angélica , Cortés Georgina Daniela , Vieyra Elizabeth , Juárez-Tapia Cinthia Rocío , Romero-Reyes Jessica , Domínguez Roberto 
Published: October 2023

In brief
The SCN regulates ovulation by stimulating the preovulatory surge of gonadotropins. This study revealed an additional role in the sensitization of the hypothalamus to estradiol that changes along the estrous cycle and the side of the nucleus.

Abstract
Ovulation is timed by neural signals originating at the suprachiasmatic nucleus (SCN) that trigger ovulation when converge with high estradiol levels, which indicates the maturation of ovarian follicles. We have shown that the hypothalamic regulation of ovulation is asymmetrical and we hypothesized that the paired SCN could contribute to such symmetries. We unilaterally lesioned the SCN of rats at each stage of the estrous cycle and evaluated the acute effects on the progression of their estrous cycle, follicular development and ovulation. Lesions prevented progression of the estrous cycle when performed in estrus/metestrus but not in diestrus/proestrus. Abnormalities in follicular development were observed in the nonovulating lesioned rats and this was independent of the side of the SCN destroyed and the stage of the cycle when surgery was performed. Groups of lesioned rats were then hormonally primed with GnRH or estradiol to assess the neuroendocrine pathway altered by the treatment. GnRH restored ovulation, suggesting that both SCN are needed for proper triggering of the preovulatory surge of GnRH and that unilateral lesion does not impair the sensitivity of the pituitary or the ovary to GnRH and gonadotropins, respectively. With regard to restoring ovulation, estradiol was asymmetrically effective in rats lesioned in estrous, partially effective in rats operated at diestrus and ineffective in rats at metestrus. Our results indicate that the SCN regulates the activity of the hypothalamic–pituitary–ovarian axis not only by modulating the preovulatory surge of GnRH/gonadotropins but also by promoting the hypothalamic integration of estrogenic signals from the ovaries in an asymmetric and stage-dependent fashion.
Imdar Sebagai Strategi Dalam Memproduksi Karya Tulis
Authors: Suwarno Wiji 
Published: October 2023

Menulis adalah suatu aktivitas komunikasi yang menjadi alternatif setelah komunikasi lisan. Menulis menjadi bahasa komunikasi yang tidak dibatasi ruang dan waktu. Setiap saat, dimana saja, dan siapa saja bisa menggunakan bahasa tulis ini untuk berbagai kepentingan. Penulisan ini mengangkat tema tentang penulisan karya tulis, dimana hal yang akan dilihat adalah strategi penulisan yang dilakukan para pustakawan pada PTKIN yang disimpulkan dalam satu bentuk metode. Penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan studi kasus. Hasil dari penelitian ini bahwa strategi menulis pustakawan dimulai dari pengumpulan ide (Idea), memetakan pokok pikiran (Mind mapping), membuat draft tulisan (Drafting), melakukan aksi menulis (Action), dan membaca kembali, dan menyempurnakan setelah semua selesai ditulis (Read and edit).
Profesionalisme Pustakawan Dalam Kajian Al-Qur’an (Telaah Terhadap Surat Al-An’am Ayat 235 dan Surat Al-Isra Ayat 84)
Authors: Syawqi Ahmad 
Published: October 2023

Tulisan ini dilatarbelakangi adanya opini yang selama ini memandang rendah terhadap profesi seorang pustakawan yang kadang dipandang sebelah mata, dikenal hanya sebagai tukang jaga buku dan pekerjaannya sangat santai sehingga tidak terlalu penting bagi sebagian orang. Tulisan ini bertujuan mengkaji ayat-ayat al-Qur’an yang membahas secara khusus tentang profesionalisme pustakawan dalam surat al-An’am ayat 235 dan surat al-Isra ayat 84. Metode yang digunakan dalam penulisan ini menggunakan teknik library research yang diuraikan secara deskriptif kualitatif dengan mengkaji berbagai penafsiran dalam al-Qur’an terkait tentang profesionalisme pustakawan. Hasil kajian dalam al-Qur’an disebutkan bahwa sikap seorang pustakawan yang profesional adalah memiliki kemampuan dalam melaksanakan segala tugas yang diembannya. Jika menempatkan seorang pustakawan dalam melakukan pekerjaannya harus memiliki kemampuan yang memadai dalam menjalankan pekerjaannya, sehingga profesi yang diembannya bisa dijalankan dengan baik. Agar tidak terjadi penyimpangan dalam menjalankan fungsi profesional pustakawan, al-Qur’an mengingatkan dengan isyarat kepada manusia agar tidak mengambil jalan pintas dengan memperlakukan orang lain untuk bekerja di luar kemampuan yang dimiliki, karena Allah SWT tidak membebani seseorang melainkan sesuai dengan kesanggupannya. Sikap profesionalisme pustakawan lainnya adalah bahwa dalam menjalankan segala pekerjaaan harus sesuai dengan petunjuk Allah dan menghindari kesesatan serta dikerjakan dengan jiwa yang bersih atau ikhlas sehingga menghasilkan pekerjaan yang berkualitas dan mampu mengangkat citra positif pustakawan sebagai profesi yang sangat mulia dan bisa dibanggakan dalam Islam. Simpulannya adalah al-Qur’an sebagai petunjuk bagi manusia memberikan panduan yang sempurna terhadap profesi pustakawan harus dijalankan secara profesional dengan jiwa yang ikhlas sehingga citra positif pustakawan sebagai profesi yang sangat mulia dan bisa dibanggakan dalam Islam
Dual-energy spectral CT for the evaluation of cancellous bone metastasis treated by stereotactic ablative radiotherapy
Authors: Hama Yukihiro , Tate Etsuko 
Published: October 2023

AbstractBackground and aimCalcium-suppressed imaging with dual-energy CT can visualize subtle cellular changes in the bone marrow. The purpose of this study was to investigate the application value of calcium-suppressed images in the evaluation of cancellous bone metastasis treated by stereotactic ablative radiotherapy (SABR).Patients and methodsDual-energy CT was performed before and after SABR in 10 patients with cancellous bone metastasis from breast cancer. Signal intensities of cancellous bone metastases to skeletal muscle were compared using calcium-suppressed images.ResultsThe relative signal intensity of cancellous bone metastasis before SABR was 0.99 ± 0.02, while after SABR it was 0.95 ± 0.06 (P < 0.05). Visual assessment of the signal intensity of cancellous bone metastases showed a decrease in signal intensity in all cases.ConclusionsCalcium-suppressed imaging with dual-energy CT may be able to evaluate cancellous bone metastases treated by SABR.
THE BRITISH COLONIAL POWER IN GEORGE ORWELL’S BURMESE DAYS
Authors: Zulkarnaen Ryan , Ruminda Ruminda , Awaludin Lili 
Published: October 2023

This study tried to discover British colonial power in George Orwell’s Burmese Days. Gramsci's hegemony theory regarding to a concept of an integral state was applied. A qualitative descriptive method was used in the study. Data in the study were dialogues and narratives from historical contacts between British and Burmese regarding the British colonial regime. The data consisted intrinsic element of theme, and 2 extrinsic elements of political society and civil society. Both elements were structure in literary works, and represent the British colonial power in George Orwell’s Burmese Days. A theme of colonial was found among the element of fiction. There were extrinsic elements such as political society and civil society. The study concluded that the intrinsic elements forming a story that could representative how the British colonial power appeared on theme. The relationship of both elements form totality of meaning and integrity that how the British colonial power operations in George Orwell’ Burmese Days. Keywords: colonialism, hegemony, integral state, orientalism
Spatial distribution of δ18O in rainwater and groundwater to identify areas of recharge in the Colombian Northwest
Authors: Ossa-Valencia Juliana , Betancur-Vargas Teresita , Campillo-Pérez Ana Karina 
Published: October 2023

The understanding of the spatiotemporal variability of the water molecule stable isotopes (δ18O and δ2H) in rain and groundwater has been used in hydrogeology to validate recharge zones. In this study, we analyzed the recharge of four aquifer systems located in northwestern Colombia. This region is characterized by highly complex topography, as the Andes Mountain range splits into three branches, two of them included in the study area. The relation in the variation of values of the δ18O‰ between Precipitation (P) and groundwater (GW) was analyzed through the arithmetic expression P/GW; when P/GW is equal or larger than 1, the recharge is direct, and values less than 1 indicate recharge from regional flows. For the purposes of this research, according to statistics criteria, values between 0.98 and 1.02 are considered as 1. It was found that on Bajo Cauca, Occidente and Urabá, the phreatic aquifers are recharged directly with rainwater or after slight evaporation processes, while the recharge of deep aquifers occur through regional flows. The Valle de Aburrá´s phreatic aquifer is also recharged from distant areas; this occurs because the surface has been impermeabilized by urban processes. The P/GW ratio seems to be useful in identifying recharge processes in regions with higher elevation gradients. In low-lying areas, the applicability of this method should be restricted.
Use and effect of fly ash in concrete: A literature review
Authors: Muñoz-Pérez Sócrates Pedro , Lozano-Sánchez Jaime Jamill , Ramírez-Silva Diana Mareline , Vallejos-Madianero Joicie Elizabeth 
Published: October 2023

Concrete production is characterized by a significant demand for energy and raw materials. The construction, maintenance, and demolition of engineering works cause excessive polluting waste that requires costly disposal. For this reason, alternative reusable materials that improve the mechanical properties of concrete, such as fly ash, are currently being investigated as an effective solution to reduce problems related to environmental impact. This paper analyzed 80 articles indexed in different databases such as ScienceDirect, IOPscience, Scielo, Ebsco, Scopus, SpringerLink, ProQuest, Dialnet, and Semanticscholar, which were not older than seven years since publication, to conduct an updated systematic review of the use, effect, and influence of fly ash on concrete. The methodologies and designs used to obtain the optimum percentages of 5, 10, and 15% were reviewed, analyzing mainly the results obtained when fly ash is used in concrete. Finally, according to the review carried out, it was concluded that fly ashes improve the mechanical and physical characteristics of concrete, and that the optimum dosage is 10% in substitution of ordinary Portland cement applied in simple concrete.
Conocimiento de profesionales de enfermería del cuidado de personas con ostomías de eliminación
Authors: MUÑOZ DELGADO ESTEFANIA , ORTEGA ORDOÑEZ GRACE CAROLINA , SALDARRIAGA OCHOA KATHERINE , BENITEZ DUQUE JOAS 
Published: October 2023

Objetivo
Identificar cual es el conocimiento de los profesionales de enfermería para el adecuado cuidado de las ostomías de eliminación.
Metodología
Se desarrolla el presente estudio de revisión integrativa de literatura, utilizando la estrategia PICO para la consolidación de la pregunta de investigación, además de 6 criterios de inclusión y 3 de exclusión para consolidar una base de datos con 28 artículos de 210 encontrados en todo el proceso de búsqueda.
Resultados
Permitió la identificación de las debilidades y falencias más comunes en el cuidado de pacientes ostomizados. A través de la discusión de los resultados se identifica el conocimiento adecuado requerido en el manejo de ostomías de eliminación, el cual se compone de tres áreas o pilares, La formación, El hacer profesional y La orientación educativa.
Conclusiones
De esta manera, los profesionales de enfermería podrán tener en cuenta algunos aspectos claves a la hora de desarrollar un plan de autocuidado eficaz.
Evidencias del profesional de enfermería durante la pandemia
Authors: VALDERRAMA CHARRIA LUZ DARY 
Published: October 2023

Durante los últimos tiempos los sistemas de salud en el mundo se han visto afectados debido a la pandemia de la covid-19. Ello ha provocado su reestructuración, pues no se encontraban preparados para esta contingencia, lo cual desbordó los servicios hospitalarios. En este contexto, es de resaltar la importancia del trabajo desarrollado por enfermeras/os no solo en el sector asistencial, sino en su labor administrativa, al ser vital para brindar atención integral y de calidad al paciente.
Objetivo
Identificar la gestión del profesional de enfermería desde la seguridad del paciente en época de pandemia.
Materiales y métodos
Revisión de literatura de artículos publicados en bases de datos científicas. Se seleccionaron diecisiete de Science Direct, Proquest y otras.
Resultados
Se encontró déficit de personal, escasez de elementos de protección e insumos, falta de protocolos adecuados, poco conocimiento y experiencia en el cuidado crítico y gran sobrecarga laboral, con repercusiones en el desempeño, la salud de los profesionales y el cuidado integral y seguro al paciente covid-19.
Conclusión
A pesar del debilitamiento y la saturación de los sistemas de salud, y las adversidades presentadas para sus profesionales, la respuesta de enfermería en la primera línea de atención fue inmediata y su gestión mostró liderazgo, compromiso y dedicación, lo cual resultó crucial para la atención integral y prestar un servicio de calidad y seguro al paciente.
Female and Male Phenotypes of Iron Deficiency in CHF. Additional analysis of the «The Prevalence of Iron Deficiency in Patients With Chronic Heart Failure in the Russian Federation (J-CHF-RF)» study
Authors: Begrambekova Yu. L. , Mareev Yu. V. , Mareev V. Yu. , Orlova Ya. A. , Kobalava Zh. D. , Karapetyan L. V. , Galochkin S. A. , Kazakhmedov E. R. , Lapshin A. A. , Garganeeva A. A. , Kuzheleva E. A. , Efremushkina A. A. , Kiseleva E. V. , Barbarash O. L. , Pecherina T. B. , Galyavich A. S. , Galeeva Z. M. , Baleeva L. V. , Koziolova N. A. , Veclich A. S. , Duplyakov D. V. , Maksimova M. N. , Yakushin S. S. , Smirnova E. A. , Sedykh E. V. , Shaposhnik I. I. , Makarova N. A. , Zemlyanukhina A. A. , Skibitsky V. V. , Fendrikova A. V. , Skibitsky A. V. , Spiropoulos N. A. , Seredenina E. M. , Eruslanova K. A. , Kotovskaya Yu. V. , Tkacheva O. N. , Fedin M. A. 
Published: October 2023

Aim To evaluate the incidence of iron deficiency (ID) in men and women with chronic heart failure (CHF) and to compare clinical and functional indexes in patient with and without ID depending on the gender.Material and methods An additional analysis of the study “Prevalence of Iron Deficiency in Patients With Chronic Heart Failure in the Russian Federation (ID-CHF-RF)” was performed. The study included 498 (198 women, 300 men) patients with CHF, in whom, in addition to iron metabolism, the quality of life and exercise tolerance (ET) were studied. 97 % of patients were enrolled during their stay in a hospital. ID was defined in consistency with the European Society of Cardiology (ESC) Guidelines. Also, and additional analysis was performed according to ID criteria validated by the morphological picture of the bone marrow.Results ID was detected in 174 (87.9 %) women and 239 (79.8 %) men (p=0.028) according to the ESC criteria, and in 154 (77.8 %) women and 217 (72.3 %) men (p=0.208) according to the criteria validated by the morphological picture of the bone marrow. Men with ID were older and had more severe CHF. They more frequently had HF functional class (FC) III and IV (63.4 % vs. 43.3 % in men without ID); higher concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and lower ET. HF FC III increased the probability of ID presence 3.4 times (p=0.02) and the probability of HF FC IV 13.7 times (p=0.003). This clinical picture was characteristic of men when either method of determining ID was used. In women, ID was not associated with more severe CHF.Conclusion Based on the presented analysis, it is possible to characterize the male and female ID phenotypes. The male ID phenotype is associated with more severe CHF, low ET, and poor quality of life. In females of the study cohort, ID was not associated with either the severity of CHF or with ET.
Comparison of fatigue behaviour and fracture toughness of cobalt chromium alloy fabricated by casting and selective laser melting methods
Authors: Harika Chembeti , Reddy K Mahendranadh , Adithya Venkat 
Published: October 2023

Co-Cr alloys are most commonly used base metal alloy in dentistry for the fabrication of many types of metallic substructures. They gained popularity due to their good mechanical properties and low cost. There are different techniques for fabrication of Co-Cr alloys which includes casting and DMLS technique. However, change in the fabrication techniques showed variation in mechanical properties. Forty Co-Cr samples each were made from two different techniques, Casting and DMLS. Fracture toughness was done with charpy’s impact test machine and fatigue behaviour test was done with nano universal testing machine. The samples were later observed under stereo electron microscope to assess the kind of failure. Unpaired t test revealed that there was statistically significant difference between two different groups. The mean difference of fracture toughness in Casting group was higher when compared with DMLS group. The number of fatigue cycles were higher in DMLS group than the casting group. Within the limitations of this in vitro study, casting group showed higher fracture toughness when compared to DMLS group, whereas fatigue limit was higher in DMLS group than casting group.
Genotyping of cryptosporidium species in cases of irritable bowel syndrome: A case control study from a tertiary care center
Authors: Bajaj Varun , Banerjee Mithu , Dubey Sudhir , Rajmohan K S , Hashmi Syed Asif , Bajaj Surabhi 
Published: October 2023

Irritable bowel syndrome (IBS) is functional bowel disorder characterized by abdominal pain or discomfort and altered bowel habits in the absence of detectable structural abnormalities. Protozoan cysts are commonly found in the stool samples of patients with IBS and a rising body of evidence suggests a direct causal relationship. Cryptosporidium infection can be a potential candidate for IBS. We studied prevalence, association, and genotype of cryptosporidium at a tertiary care centre. Using a case-control design, a total of 100 cases and 100 controls were selected between 2016 and 2017. Fresh stool samples were collected and processed for microscopic examination. Positive samples were subjected to PCR RFLP for speciation and results analysed for Odd’s ratio, relative risk and relationship between variables. There was a high male preponderance (m: f=9:1). Most patients belonged to the middle age group (34.8-42.4 years). Amongst the clinical subtype IBS with diarrhoea (IBS-D) was the most common subtype (63%). Odd’s ratio for having IBS was 57.5 with cryptosporidium with a relative risk of 2.09. Adjusted Odd’s ratio for age was 1.014 suggesting a linear correlation (r value=0.07) with age. Our study shows a significant risk of developing IBS with cryptosporidium infection. The authors recommend studies with larger population samples both within the northern regions of India and across the country to determine prevalence, speciation of cryptosporidium and its relationship to IBS.
Perceived Stress, Mental Well-Being and Coping on Parents of Disabled Children from Mainstream and Special Schools
Authors: Pachița Irina-Cristina , Gherguț Alois 
Published: October 2023

Raising children with special needs increases the level of family stress and undoubtedly affects the mental well-being of its members. Parents' ability to adapt to this challenge, which causes stress and various unpleasant emotions, will have an effect both on them and on the children. We hypothesized that perceived stress is a significant predictor for parents’ mental well-being and that this relationship is moderated by different copying strategies used by them. Moreover, we hypothesized that the type of school in which children are enrolled predicts the level of stress reported by the parents. 202 parents of children with disabilities in special schools and mainstream schools, aged between 21 and 66 years old, completed a questionnaire to measure stress levels, mental well-being and the coping strategies used by them. Regression and moderation analyses were conducted. Parental stress was a negative predictor of mental well-being, and problem-focused coping and emotion-focused coping were moderators of the relationship between the two variables, with lower levels of stress and higher levels of mental well-being for the use of these strategies. Avoidant coping did not represent a moderator in this relationship, being correlated with higher levels of parental stress. Children’ parents in special education have experienced higher levels of stress than children’ parents in mainstream schools. Findings suggest that the way parents of disabled children manage to cope with the stressors influence their mental well-being, offering support in understanding this phenomenon and setting objectives of psycho-emotional intervention for parents.
Zoning of the Territory of the Saratov Region by the Intensity of Epidemic Manifestations of HFRS using GIS Analysis
Authors: Chumachkova E. A. , Ivanova A. V. , Porshakov A. M. , Vyatkin I. N. , Forostyanaya M. V. , Chumachkov K. Ya. , Toporkov V. P. 
Published: October 2023

The aim of the study was to zone the territory of the Saratov Region using indicators that influence the intensity of epidemic manifestations of hemorrhagic fever with renal syndrome (HFRS), and to assess the risk of infection of people for a differentiated approach to the organization of anti-epidemic measures in natural foci.Materials and methods. When calculating the intensity of epidemic manifestations of HFRS in the administrative-territorial units (ATUs) of the Region, the indicators that have the greatest impact on the risk of infection were selected: the intensive rate of morbidity among population, the rate of infection of carriers with the HFRS virus, the number of recreational facilities, and the forest cover rate. The paper presents personalized data of HFRS patients, the results of epizootiological monitoring, information about recreational facilities and the forest fund of the Saratov Region. All the data considered cover the period of 2010–2022 for each of the administrative districts of the Region and the city of Saratov. To calculate the intensity of epidemic manifestations, the dimension method and the decimal logarithm were used.Results and discussion. As a result of calculations, 8 ATU of the Regions have been classed as the territories with the highest intensity of epidemic manifestations and the risk of HFRS infection, with high intensity – 9, with medium – 10 and low – 12. Epidemiological geo-information analysis made it possible to establish that the territories with the highest intensity of epidemic manifestations of HFRS occupy 15.8 % of the area of the region, high – 23.8 %, medium – 28.5 %, low – 31.9 %. Based on the findings of the study, 16 districts of the Region and the city of Saratov were identified as the most dangerous in terms of HFRS infection. Namely these territories that primarily require targeted epizootiological monitoring for early and effective management of preventive activities.