bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Manifestations in Inflammatory Bowel Disease
Authors: Reddy Meda Anish Kumar , Fredrick Fremita Chelsea , Rathod Urvashi , Shah Priyanshi , Jain Rohit 
Published: November 2023

Abstract:
Inflammatory bowel disease is a group of long-term systemic inflammatory disorders
affecting the gastrointestinal tract, including Crohn's disease and ulcerative colitis, which may be
associated with an increased risk of developing extraintestinal manifestations, including cardiovascular
disease, thereby decreasing the quality of life. Pathophysiological changes associated
with inflammatory bowel disease include alterations of the microbiome, endotoxemia, and
changes to glucose and lipid metabolism. Inflammatory bowel disease patients have higher carotid
intima-media thickness, lower flow-mediated dilatation, and increased carotid-femoral pulse
wave velocity, which are markers of elevated cardiovascular risk. In addition, inflammatory
bowel disease patients are at an increased risk for developing venous and arterial thrombotic
events due to a hypercoagulable state caused by thrombocytosis and coagulation system activation.
To reduce the risk of developing cardiovascular disease, lifestyle modifications, such as
smoking cessation, dietary changes, and increased physical activity alongside management with
appropriate medication, should be considered. This research paper examines how inflammatory
bowel disease can influence the risk of cardiovascular complications and the involvement of
drug therapy.

Methods:
PubMed was searched using keywords, such as inflammatory bowel disease, Crohn's
disease, ulcerative colitis, cardiovascular disease, pericarditis, thromboembolism, and many
more. Relevant literature up to March 2023 has been examined and summarized, which consisted
of data from various clinical trials, meta-analyses, retrospective/prospective cohort studies, and
current guidelines.
The Effect of Preparation Design on Stress Distribution in Lithium Disilicate Laminate Veneer using 3D Finite Element Analysis.
Authors: Abid Shahad Emad , Mohammed Kasim Gholam 
Published: November 2023

Background:
A layer of ceramic bonded to the facial surfaces of prepared teeth to create a ceramic esthetic veneer, also known as a laminate veneer.

Objective:
This study aimed to examine the effect of preparation design on the stress distribution in lithium disilicate veneer at different angulations of masticatory loading.

Methods:
The finite element approach assessed the structure stress distribution. So, Exocad dental CAD was used to obtain the models, which consist of an upper central incisor in three dimensions (3D), and prepare them with the same software for an indirect veneer. The models were imported into software (SolidWorks; Dassault Systems) to construct solid models. The external load used in this study was 100 N at 60 degrees (intercuspal) and 125 degrees (protrusive) in the palatal surface, two mm below the incisal edge. The models were restored using e-max laminate veneers with different tooth preparation designs (palatal chamfer and window preparation designs). Analysis and calculations were performed on the stress distributions and maximum stress values of the tooth structures, cement layer, and laminate veneer.

Results:
With a window preparation design, the maximum stress values in the tooth and laminate veneer were higher. In the palatal chamfer design, stresses were dispersed more consistently through the cement layer and laminate veneer. Higher stress was generated by protrusive movement than by intercuspal movement.

Conclusion:
Compared to window preparation, the palatal chamfer design for lithium disilicate laminate veneer showed a more favourable stress distribution. Regardless of the preparation design, maximum stress values were observed in the cervical and incisor areas of the tooth structure.
Latest Evidence on Orthognathic Surgery Techniques and Potential Changes in Oral Microbiota related to Intermaxillary Fixation in Orthodontic Patients: A Systematic Review
Authors: Pellegrini Matteo , Nardi Maria Gloria , Pulicari Federica , Scribante Andrea , Garagiola Umberto , Spadari Francesco 
Published: November 2023

Background:
Orthognathic surgery is often applied for the correction of facial dysmorphia, and different findings were highlighted regarding the techniques applied. After surgical treatment, intermaxillary fixation is placed, which compromises oral hygiene and, consequently, can lead to increased plaque accumulation and microbiological changes, promoting the proliferation of periodontopathogenic bacteria. Therefore, the aims of the present review are to describe the main evidence from the last 20 years of clinical studies concerning surgical techniques applied to orthognathic surgery and, finally, to analyze potential changes in the oral microbiota.

Materials and Methods:
An electronic search was conducted in the PubMed (MEDLINE) and Scopus databases; the MeSH (Medical Subject Heading) terms are bacteria, dental plaque, evidence-based practice, maxillomandibular fixation, microbiota, operative procedures, and orthognathic surgery.

Results:
At the end of the search process, 31 relevant articles were finally included and analyzed in this systematic review, which has a low risk of bias. Clinical studies on humans have been considered in this review. Based on the studies included it would be preferable to use piezoelectric technology in osteotomies because of its many advantages, “surgery-first” technique allows for results comparable to the standard technique in Class III malocclusions while improving quality of life more rapidly, the “mandible-first” technique seems to have more advantages than the “maxilla-first” technique, Computer-Aided Design and Manufacturing (CAD/CAM) could provide more accurate and precise results, and finally, Laser can be applied with different advantages. Regarding intermaxillary fixation, no long-term increase in the concentration of periodontal bacteria was recorded.

Conclusion:
Several findings still need to be confirmed with reference to the best suturing technique to reconstitute the nasal wing base, the real effectiveness of “surgery-first,” “maxilla-first,” and “mandible-first” approaches in patients with Class III malocclusion, the use of CAD/CAM and Laser, more studies should be conducted to evaluate quantitative and qualitative changes in other microorganisms following intermaxillary fixation.
Effect of Aging and Different Surface Treatments on Repair Bond Strength of Hybrid Resin Composites
Authors: Saleh Somaya Ali , Hashem Danya , Salem Reham Mohammed 
Published: November 2023

Background:
With the trend for minimally invasive dentistry and the rapid evolution of composite resin materials, repair of defective composite resin restorations is a popular choice rather than replacement of the restoration. The durability of the bond between the old and repaired composite restoration is important for a successful outcome.

Objective:
To evaluate the immediate and delayed shear bond strength of two types of repaired hybrid resin composites using different chemical and mechanical surface treatments.

Methods:
Two types of hybrid resin composites, micro-hybrid resin composite and nanohybrid resin composite, were used to prepare 288 pre-polymerized resin composite specimens. After polymerization, repair was done after 24 hours and 6 months. Each hybrid resin composite group was divided into 3 groups according to surface treatment used to repair the substrate: group 1: no surface treatment, group 2: treated by medium abrasive stone, and group 3: treated by fine abrasive stone. Each group was further subdivided into 3 subgroups according to different agents used for repair: group 1: Silane, group 2: Universal adhesive, and group 3: Silane + adhesive. Shear bond strengths of the repaired specimens were measured using a Universal testing machine. Failure modes were evaluated under a stereomicroscope.

Results:
Different chemical and mechanical surface treatments had a significant effect on the shear bond strength values of all groups (p ≤ 0.05). The highest mean shear bond strength values were found in nano-hybrid composites immediately repaired by silane after treatment by a medium abrasive stone while the lowest mean shear bond strength values were found in micro-hybrid composites with delayed repair and no surface treatment.

Conclusion:
Diamond burs using silane with adhesive improved the repair bond strength of the tested hybrid composites. In composite repair, using abrasive mechanical pretreatment followed by adhesive conditioning is crucial for the success of the repair restoration.
Photogrammetric and Cephalometric Analyses of Ricketts' Esthetic Line in Malaysian Malay Adults: A Cross-sectional Study
Authors: Lepi Juliza Md , Mahmud Melati , Wah Lim Tong , Norman Noraina Hafizan 
Published: November 2023

Objective:
To compare and correlate the Ricketts Esthetic Line measurement between photographs and lateral cephalogram. The norm for evaluating Ricketts' E-Line in the Malaysian Malay population is to be established.

Materials and Methods:
This was a cross-sectional study involving 126 pre-existing photographs and lateral cephalometric radiographs of skeletal Class I Malaysian Malay aged 19 to 40 recruited from the Orthodontic Clinic of Universiti Teknologi MARA (UiTM). Photogrammetric and cephalometric analyses of the upper and lower lips to Ricketts' E-line were performed. A paired t-test was performed to determine any statistically significant difference between the photographic and cephalometric variables. In addition, Pearson correlation was conducted to estimate the correlations between the photographic and cephalometric variables.

Results:
There was no significant difference between photographs and lateral cephalogram methods in the upper and lower lip to E-line measurement (p>0.05). For the photogrammetric analysis, the distance from the upper lip to the E-line was -0.30mm ±2.46, whereas the cephalometric analysis was -0.43mm ±2.63. The lower lip distance to the E-line for the photogrammetric analysis was 1.44mm ±2.8, whereas the cephalometric analysis was 1.24mm ±3.08. The Pearson correlation coefficient (r) for photographs and lateral cephalometric variables was close to 1 (0.914 and 0.898, respectively), indicating a robust positive correlation between the two variables.

Conclusions:
Photographic and cephalometric analysis can be used synonymously in measuring the Ricketts E line. Malaysian Malay has a more protrusive upper and lower lip to the E-line, compared to Caucasians, and the norm for the investigated population was established.
Anticancer Potential of Hemidesmus indicus-enriched Pt/Au Bimetallic
Nanoparticles against Human Breast and Skin Cancer Cell Lines
Authors: Bagal Vinay A. , Naresh Vijay , Disouza John I. , Mali Uma G. , Bhinge Somnath 
Published: November 2023

Background:
Worldwide, cancer has become the most disastrous disease, causing an
enormous number of deaths in the population. According to GLOBOCON, in the year 2020, there
were 1.93 crore cases of cancer reported and 10 million deaths caused by cancer.

Methods:
Metallic nanoparticles, such as gold, silver, and platinum, which possess properties of bioenvironmental stability, safety, and lower toxicity, have become preferred materials for drug delivery. Bimetallic nanoparticles, in particular, have shown enhanced optical, magnetic, electrical, catalytic, and medicinal properties compared to monometallic nanoparticles. We have developed goldplatinum PtAuBNPs containing H. indicus methanolic extract using a green synthesis approach. The
PtAuBNPs were characterized by UV-visible spectroscopy, particle size analysis, zeta potential
measurement, and surface characteristics using TEM, XRD, Raman spectroscopy, and DSC. The
anticancer activity of PtAuBNPs was investigated using two distinctive cell lines, MCF-7 and
B16F10.

Results:
The change in the colour of the prepared systems after incubation indicated the development
of nanoparticles, as analysed by UV spectroscopy. The PtAuBNPs showed a particle size of 243.3
nm and a zeta potential of -14.4 mV. TEM analysis showed the hexagonal and cubic nature of the
nanoparticles. XRD analysis indicated the crystalline nature of the nanoparticles. The bimetallic
nanoparticles showed greater anticancer activity against the breast cancer cell line (MCF-7) and the
skin cancer cell line (B16F10), with IC50 values of 35.52µg mL-1and 30.22 µg mL-1, respectively,
which have been found to be lower than the standard 5-FU.

Conclusion:
The development of PtAuBNPs may pave the way for a new era of enhancing the anticancer activity of herbal extracts through the synergistic effects of gold and platinum metals. The
developed PtAuBNPs have been shown to exhibit excellent anticancer activity against skin and
breast cancer.
Short-Term Load Forecasting Based on CNN-Bilstm Considering Load
Time-Varying Trend Mapping
Authors: Ji Yuqi , Yan Yabang , Liu Xiaomei , He Ping , Li Congshan , Tao Yukun , Fan Jiale 
Published: November 2023

Background::
Accurate short-term load forecasting is an important guarantee for the
safety, stability, economic and efficient operation of power systems.

Objective::
In order to effectively improve the forecasting accuracy, this paper proposes a hybrid
forecasting model of convolutional neural network (CNN) and bi-directional long short-term
memory (BiLSTM) neural network considering load time-varying trend mapping model (M).

Methods::
Firstly, the time-varying features of the load curve are analyzed, and a mapping model
is established to characterize the load time-varying trend. The features of the load time-varying
trend are extracted, and they are quantified into a mathematical model. Secondly, the feature set
is reconstructed through data migration. Then, the reconstructed feature set is input into the
CNN-BiLSTM hybrid model. In the hybrid model, CNN is used to extract the features from data
again to form a new feature vector, and then the feature vector is input into BiLSTM for forecasting.

Result::
The power load data set from the New England in United States is used to simulate and
verify the correctness and validity of the proposed method.

Conclusion::
With the comparison of the forecasting results between different load forecasting
models, the results show that the forecasting accuracy of the proposed method is higher and it is
verified that the load time-varying trend mapping method proposed can improve the forecasting
accuracy of different models in varying degrees.
Is It Safe to Take 650 mg of Paracetamol on a Regular Basis?
Authors: Kadiri Sunil Kumar , Uchil Deepika , Guruprakash Dhani Movuram , Sathavalli Dhritija , Singh Durgesh 
Published: November 2023

:
The commonest medication to treat moderate to severe pain and fever in adults and children is paracetamol and it has been observed that there has been a rapid increase in the intake of
paracetamol-650 since the COVID-19 pandemic and it has continued to date. This analgesic and
antipyretic medication showed an increase of 150% in its consumption during the pandemic, simultaneously escalating its self-medication. Concerns have been expressed about the indirect advertising
of prescription medications, their illogical use, and improper self-medication, which has resulted in
overdose and certain serious side effects. Chronic pain and pyrexia are the most common symptoms
witnessed during the COVID-19 pandemic. The intake of paracetamol-650 has also been increased
as a prophylactic measure due to the widespread fear generated during COVID-19. The usage of
paracetamol has been shifted from 500 mg to 650 mg for mild and moderate pain and fever during
and after the end of the pandemic. This raises concerns about the misuse of paracetamol-650mg
which may cause damage to the liver, stomach, and kidney chronically. So, this review article aims
to generate awareness among the public and physicians about the rationale of paracetamol as an analgesic and antipyretic.
Evaluation of the Effect of Two Surface Treatment Methods on Shear Bond Strength between Porcelain Veneer and Two Different Zirconia Blocks
Authors: Barzegar Ali , Ghaffari Tahereh , Negahdari Ramin , Dizaj Solmaz Maleki , Saghari Reyhaneh 
Published: November 2023

Introduction:
The aim of the study was to test the effect of two surface treatment methods on shear bond strength between a porcelain veneer and two different zirconia blocks.

Materials and Methods:
Sixty disk-shaped zirconia samples (30 samples of Novi brand and 30 samples of Rainbow brand) were used (diameter of 10 mm and thickness of 4 mm). Based on surface treatment, the samples were randomly divided into 3 groups: control, air-particle abrasion, and Zircos-E Etching Solution. Using the metal mold, the porcelain was veneered on the zirconia surface and then fired. Then, all samples were subjected to shear bond strength testing using a universal testing machine at a speed of 1 mm/min until breaking.

Results:
There was a statistically significant difference between the mean variable shear bond strength of the control group and two other groups, so the shear bond strength in the control group was less than in both groups. And there was no statistically significant difference between the mean variable of shear bond strength in the two groups of “airborne particle abrasion” and “Etching”. There was a statistically significant difference between the mean shear bond strength of the two types of zirconia samples and this amount was lower in Novi than in Rainbow. There was also no interaction between the type of surface preparation and the type of zirconia.

Conclusion:
It can be concluded that surface preparation with air particle abrasion and etching increases the shear bond strength of zirconia to porcelain veneer and the shear bond strength of zirconia and porcelain veneer is affected by the type of zirconia.
Learnings From Implementation of Technology-Enabled Mental Health Interventions in India: Implementation Report
Authors: Kallakuri Sudha , Gara Sridevi , Godi Mahesh , Yatirajula Sandhya Kanaka , Paslawar Srilatha , Daniel Mercian , Peiris David , Maulik Pallab Kumar 
Published: November 2023

Background
Recent years have witnessed an increase in the use of technology-enabled interventions for delivering mental health care in different settings. Technological solutions have been advocated to increase access to care, especially in primary health care settings in low- and middle-income countries, to facilitate task-sharing given the lack of trained mental health professionals.

Objective
This report describes the experiences and challenges faced during the development and implementation of technology-enabled interventions for mental health among adults and adolescents in rural and urban settings of India.

Methods
A detailed overview of the technological frameworks used in various studies, including the Systematic Medical Appraisal and Referral Treatment (SMART) Mental Health pilot study, SMART Mental Health cluster randomized controlled trial, and Adolescents’ Resilience and Treatment Needs for Mental Health in Indian Slums (ARTEMIS) study, is provided. This includes the mobile apps that were used to collect data and the use of the database to store the data that were collected. Based on the experiences faced, the technological enhancements and adaptations made at the mobile app and database levels are described in detail.

Implementation (Results)
Development of descriptive analytics at the database level; enabling offline and online data storage modalities; customizing the Open Medical Record System platform to suit the study requirements; modifying the encryption settings, thereby making the system more secure; and merging different apps for simultaneous data collection were some of the enhancements made across different projects.

Conclusions
Technology-enabled interventions prove to be a useful solution to cater to large populations in low-resource settings. The development of mobile apps is subject to the context and the area where they would be implemented. This paper outlines the need for careful testing using an iterative process that may support future research using similar technology.

Trial Registration
SMART Mental Health trial: Clinical Trial Registry India CTRI/2018/08/015355; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjMyNTQ=&Enc=&userName=CTRI/2018/08/015355. ARTEMIS trial: Clinical Trial Registry India CTRI/2022/02/040307; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=NDcxMTE=&Enc=&userName=CTRI/2022/02/040307
Remote Delivery of the Cuidándome Telehealth Intervention for Self-Management of Depression and Anxiety Among Latina Immigrant Women: Randomized Controlled Trial
Authors: Alvarez Carmen , Aryal Subhash , Vrany Elizabeth , Sanchez R Maria Jose , Quiles Rosalphie , Escobar-Acosta Lia , Hill-Briggs Felicia 
Published: November 2023

Background
Growing evidence suggests that Latina immigrant survivors of adverse childhood experiences (ACEs) are at increased risk for developing and remaining with either depression or anxiety or both symptoms. This study examined the feasibility and acceptability of a telehealth intervention—Cuidándome (quee-DAN-doh-meh, “taking care of myself”). Cuidándome is a 10-week, patient-centered, trauma-informed intervention delivered by a trained facilitator that promotes self-management of depression and anxiety symptoms through improved problem-solving skills and strategies.

Objective
The aim of this study was to examine the feasibility and acceptability of Cuidándome delivered remotely (via Zoom) with Latina immigrant ACE survivors with either depression or anxiety or both symptoms. We also estimated the effect sizes associated with the intervention on decreasing depression and anxiety symptoms and improving social problem–solving styles.

Methods
We evaluated Cuidándome using a randomized controlled trial design. Latina immigrants (N=47) who had experienced at least 1 ACE and had at least mild depression or anxiety symptoms were randomized to Cuidándome or a comparison group delivered by trained facilitators. We assessed for changes in depression and anxiety symptoms as well as social problem–solving styles at baseline, post intervention, and 3- and 6-month follow-up.

Results
Analyses indicated significant decreases over time within both Cuidándome and comparison groups for depression and anxiety symptoms and maladaptive problem-solving. The intervention effect was largest for anxiety; at 6-month follow-up, Cuidándome participants had significantly lower anxiety scores than the comparison group. In addition, we observed a greater average point reduction in depression symptoms at 6 months among Cuidándome participants (5.7 points) than in the comparison group (3.7 points).

Conclusions
A mental health program delivered via Zoom by a trained facilitator was feasible and acceptable to Latina immigrant women and can be beneficial for reducing anxiety and depression symptoms. More research is needed to assess the effectiveness of Cuidándome among a powered sample size of Latina immigrants.

Trial Registration
ISRCTN Registry ISRCTN16668518; https://www.isrctn.com/ISRCTN16668518