bluuebunny/crossref_metadata_2025_split huggingface dataset:
P1222 Gut microbiome differences regarding lifestyle and the history of COVID-19 infection in ulcerative colitis patients
Authors: Straume Z , Krumina N , Elbere I , Rozenberga M , Rudzite D , Ozolina J , Pjalkovskis J , Megnis K , Skuja V , Krumina A 
Published: January 2024

Abstract

Background
The microbiome contributes to the pathogenesis of ulcerative colitis (UC) but the contribution of different lifestyle and environmental factors to the compositional variability of the gut microbiota is unclear. Also, it is known that microbiota plays an important role in infectious diseases like coronavirus disease 2019 (COVID-19).

Methods
In 6-month time (June 2021 to December 2021) 49 UC outpatients from Riga East Clinical University Hospital were included in a Cross-sectional study. All patients were divided into groups according to COVID-19 status (COVID-19posvs COVID-19neg) within 6 months. The effect of the lifestyle (smoking cigarettes, alcohol intake, sports activities, and high psychological stress level) and COVID-19 to the gut microbiota in patients with UC was investigated. For taxonomical classifying of the gut microbiome metagenome data, MetaPhlAn v.2.6.0 tool was used. In further analysis gut microbiome (mostly bacteria phyla) and related data was analysed with SPSS 20.0.

Results
Out of 49 patients, 31(63%) were male and 18(37%) were female, the mean age was Md=38 [IQR:34-51]. Fourteen patients (28.6%) have been COVID-19 pos and 35(71.4%) COVID-19 neg. There were no statistically significant differences between COVID-19 pos and COVID-19 neg patients and their microbiota, nor between COVID-19 pos symptomatic 12(24.5%) and asymptomatic 37(75.5%) patients and their gut microbiome. Out of 49, 24(49%) were doing sports, of those 18(51.4%) were COVD-19neg vs. 6 (42.9%) COVID-19pos, p=0.82. Evaluating differences in the gut microbiome regarding physical activities there was no statistical significance. Of 49 patients, 30(61.2%) have smoked before, while 19(38.8%) haven’t smoked. Medium smoking time was 8 years Md=8 [IQR:4.50-20.0]. Analysing gut microbiome in smokers/non-smokers, and the length of smoking, there were found no statistically significant differences. Thirty-five (71.4%) were using alcohol, and 14(28.6%) were not. Those who were using alcohol had statistically significantly more Firmicutes in their gut microbiome Md= 64.8[IQR:53.7-70.4] than no users Md=48[IQR:37.5-66.3], p=0.041. Regarding high stress levels, those who had less stress 18(36.7%), had more Actinobacteria in their gut microbiome Md=11.7[IQR:6.92-14.8] vs stressful patients 31(63.3%) Md=6.03[IQR:2.23-13.8], p=0.03.

Conclusion
There were no changes in gut microbiome in COVID-19 positive and COVID-19 negative patients, nor in smokers and no smokers. Alcohol users had more bacteria Firmicutes in their gut microbiome. There were no differences in gut microbiome in UC patients doing or lacking sports. UC patients with less stress had more Actinobacteria in their gut microbiome.
P1232 Alterations in microbial composition in patients with newly diagnosed Crohn's disease over a course of one year: data from a prospective longitudinal real-world study
Authors: Sharar Fischler T , Reshef L , Godny L , Freidenberg A , Pauker M , Rabinowitz K , Avni-Biron I , Gophna U , Dotan I , Yanai H 
Published: January 2024

Abstract

Background
Gut microbial composition in Crohn's disease (CD) is variable, changing with specific interventions. We aimed to explore the dynamics in microbial alterations in a cohort of patients with newly diagnosed Crohn's disease (ndCD) over one year.

Methods
This was a prospective longitudinal real-world study of patients with ndCD1 naïve to therapy who were treated at the physician's discretion. Clinical outcomes at one year were corticosteroid-free clinical remission (CSFR) and biochemical remission ([BR], CRP&lt;1mg/dL and FC&lt;150ug/g). We sequenced paired stool samples from diagnosis and after one year using 16S rRNA gene (V4) and analyzed changes in diversity and dysbiosis indices. A linear mixed-effect model was constructed to identify factors associated with microbial alterations and to identify specific genera that drove the alterations while controlling for confounders.

Results
Seventy-five patients completed one-year follow-up (49.3% female, median age 27 years [IQR 22-38.5], therapeutic interventions: 45 patients on biological therapies [43 anti-TNF], 26 antibiotics, 10 corticosteroids, 5 underwent surgery, and 59 various nutritional interventions). Rates of CSFR, BR, and conjoined CSFR-BR at one-year post-diagnosis were 64%, 56%, and 45.3%, respectively. We observed an overall significant increase in microbial Shannon diversity (H index), p&lt;0.001, and decreased microbial dysbiosis index (MDI), p=0.007, from baseline to one year. On subgroup analysis, these alterations were significant among patients who achieved the clinical outcomes (all p&lt;0.05) and even more prominent among patients who were on biological therapies (both indices p&lt;0.001). Notably, in the biological therapy subgroup, the microbial composition at diagnosis was less diverse and more dysbiotic than in the non-biological subgroup. In the latter, microbial composition at diagnosis was less disrupted and remained relatively stable over time. Linear mixed model analysis corroborated a positive association between biological therapy and the positive dynamics in microbial indices (H-index, p=0.020 and MDI, p=0.040). Fifteen specific genera drove the microbial alterations over time (Table 1), while alterations in the relative abundance of some genera correlated with changes in clinical biomarkers and clinical indices (Figure 1).

Conclusion
The microbial composition of this real-world cohort of patients with ndCD improved over the course of one year, which was significant for patients who achieved clinical outcomes and was more prominent for patients requiring biological therapy. In this subgroup, the microbial signature was less diverse and more dysbiotic when diagnosed; this likely led the significant improvement over time.
1 Yanai H,et al. Crohns Colitis 360 2023;5:otad064
P1233 Serum insulin is associated with c-reactive protein and gut microbial diversity in inflammatory bowel disease
Authors: Wark G , Kaakoush N O , Samocha-Bonet D , Ghaly S , Danta M 
Published: January 2024

Abstract

Background
Obesity, impaired glucose tolerance and unfavorable lipid profile are established risk factors for cardiovascular disease. Patients with inflammatory bowel disease (IBD) may be at increased risk of cardiovascular disease, and new therapies such as JAK inhibitors may further add to this risk. C-reactive protein (CRP) is a marker of systemic inflammation that may increase with active IBD and is correlated with metabolic risk in non-IBD cohorts. Diet, in particular consumption of ultra-processed foods, has been linked to gut dysbiosis and the onset, course, and response to treatment of both IBD and metabolic disease. The aim of this study was to identify metabolic risk in a cohort of individuals with IBD through an analysis of diet, metabolic parameters and stool microbial diversity.

Methods
This two-week prospective case-control study enrolled non-diabetic individuals with IBD in clinical remission and healthy individuals (HC). Baseline body mass index (BMI), waist circumference (WC) and waist to hip ratio, detailed diet diary, serum metabolic and inflammatory parameters, stool bacterial microbiota and faecal calprotectin (FC) were examined.

Results
Eighty-one participants; 57 with IBD (26 ulcerative colitis (UC), 31 Crohn’s disease (CD)) and 24 HC participants were recruited. In the IBD group, there was a positive correlation between serum insulin, triglycerides, BMI and WC with CRP and a negative correlation between HDL and CRP (Table 1). There were no associations between measured metabolic risk factors and FC. Stool microbial alpha diversity of the IBD group was lower than that of the HC cohort, with lower species richness (IBD 21.4 v HC 26.8, p&lt;0.01) and Shannon’s diversity index (SDI) (IBD 3.1 v HC 3.4, p=0.03) (Figure 1). In the IBD group, there was a negative association between serum insulin and CRP with stool species evenness (SE) and SDI (insulin: SE r=-0.41, adj-p=0.02, SDI r=-0.39, adj-p=0.02; CRP: SE r=-0.4, p=0.02, SDI r=-0.4, p=0.02) and a negative association between intake of processed meat and stool alpha diversity metrics (SE r=-0.39, adj-p=0.046 and SDI r=-0.42, adj-p=0.02 respectively). There were no significant associations between serum metabolic profile and dietary intake with stool alpha diversity in the HC group.

Conclusion
Unhealthy diet, higher body weight and suboptimal glucose control were positively associated with CRP in participants with IBD. Gut microbiota with reduced diversity may be a common link between adverse metabolic outcomes and IBD. Serum insulin should be explored as a common biomarker of metabolic and gut microbial health.
N02 Inflammatory bowel disease patients with impaired quality of life on biologic therapy benefit from the support of an IBD nurse specialist: Results of a randomized controlled trial in Germany (IBDBIO-ASSIST study) - The IBD nurses perspective
Authors: Hartmann P , Zemke J , Plachta-Danielzik S , Steiner I M , Pohlschneider D , Urzica E , Tappe U , Schreiber S , Steinkat N , Langbrandtner J , Hüppe A , Stargardt T , Bokemeyer B 
Published: January 2024

Abstract

Background
IBD nurses play an important role in the Multidisciplinary Team of managing patients with IBD. IBDBIO-ASSIST was a randomised controlled trial assessing the efficacy of care provided by an IBD nurse specialist in improving health-related quality of life (QoL) in IBD patients on biologic therapy in an outpatient setting in Germany.

Methods
In total, 1086 IBD patients on biologic therapy were randomly assigned to either a control group (CG) receiving usual IBD care or an intervention group (IG) receiving additional care from an IBD nurse. Two IBD nurses per site received an extra study specific IBD training before including patients. The primary outcome was disease-specific QoL (sIBDQ) assessed at months (M) 6, 12, and 18. In addition, IBD nurses provided a final assessment of various aspects of their work in the context of the study at M6 (T0) and M15 (T1), and patients were asked about their satisfaction level with the IBD nurses.

Results
The analysis of patients with impaired QoL at baseline (EQ-VAS &lt; 75 [median]), showed an improvement in sIBDQ over 6 M that became significant at M12 and remained significant through M18 (baseline: IG 4.24; CG 4.31; M18: IG 5.02; CG 4.76; P= .017) (Table 1). Regarding the 5 aspects of fun, usefulness, successful discussions in consultations with patients, successful support of patients, and appreciation by patients, the nurses expressed positive assessments (“completely” and “rather”) at both measurement points, with values of more than 90% (Fig. 1). About 20% to 30% of the nurses reported being rather dissatisfied with two aspects of their jobs: time and space resources for discussions and recognition by physicians. 94% of patients in the IG felt that the additional care provided by the IBD nurses was highly beneficial.

Conclusion
IBD patients with impaired QoL derived a significant benefit from the additional care provided by an IBD nurse specialist, leading to meaningful improvements in sIBDQ over the long term. The survey results from the IBD nurses and patients in the IG revealed a very positive perception of the new form of care. It is noteworthy that an improvement in care provision was reported both by the nurses and the participating patients. Some physicians also experienced benefits from the intervention as they were relieved of certain time-consuming tasks by the IBD nurses. It should be noted that more than 20% of the IBD nurses did not feel sufficiently appreciated by physicians, and about 30% criticised the lack of time and space resources. When introducing the IBD nurse-led care concept into usual practice, these aspects should be considered.
N11 The effect of progressive relaxation techniques on disease activity, anxiety, sleep, and quality of life in individuals with Ulcerative Colitis
Authors: Artan Y , Yıldırım Y , Unal N G 
Published: January 2024

Abstract

Background
The aim of the study was to determine the effect of progressive relaxation techniques on disease activity, anxiety, sleep quality, and quality of life in individuals with ulcerative colitis.

Methods
This study was conducted as a randomized controlled three-arm experimental study. A total of 56 patients with ulcerative colitis were randomly divided into a progressive relaxation (n=19), placebo (n=19) and control (n=18) group. The data of the study were collected using the "Individual Identification Form", "Partial Mayo Score", "State-Trait Anxiety Inventory", "Pittsburgh Sleep Quality Index", and "Inflammatory Bowel Disease Quality of Life Questionnaire". Progressive relaxation techniques were applied to individuals in the progressive relaxation group by providing a video and educational brochure and practicing at least once a day for 25-minute sessions for 8 weeks; a special music selection for relaxation was played for individuals in the placebo group for at least one 25-minute session a day for 8 weeks. No application was made to individuals in the control group. Data collection forms were applied to all individuals before and 4th and 8th weeks after the application.

Results
The average age of the participants in the study was 38.75±11.47, and 51.8% of them were female. It was found that there was a decrease in disease activity scores at the 4th and 8th weeks in both the progressive relaxation and placebo groups, with a greater decrease observed in the progressive relaxation group.This difference was not statistically significant.
Anxiety levels of the individuals, it was found that there was a statistically significant decrease in both state and trait anxiety score averages at the 4th and 8th weeks in both the progressive relaxation and placebo groups, with a higher percentage of decrease observed in the progressive relaxation group (p&lt;0.05).
Sleep quality score averages at the 4th and 8th weeks, it was found that there was no statistically significant change in the control group, while the score averages of both the progressive relaxation and placebo groups significantly decreased, with a higher percentage of decrease observed in the progressive relaxation group (p&lt;0.05).
In the progressive relaxation and placebo groups, it was found that the life quality score averages significantly increased at the 4th and 8th weeks, with a higher percentage of increase observed in the progressive relaxation group (p&lt;0.05).

Conclusion
Our study has shown that progressive relaxation techniques can reduce anxiety levels and improve sleep and quality of life in individuals with ulcerative colitis.
N15 Developing a Tool for educating newly diagnosed Patients with Inflammatory Bowel Disease based on a Quality Database Indicator
Authors: Kjaer-Mikkelsen E , Edelbo R , Riddersholm C , Blichfeldt B , Krogager Y , Andersen D V , Berg A 
Published: January 2024

Abstract

Background
There is evidence that education improves quality of life and empowers patients with chronic diseases including inflammatory bowel disease(IBD).
Education also indicates a better use of ressources enabling relevant treatment to be started earlier.
Education meets an increasing wish from patients to be involved.
ECCO recommend patient education and state that this is well handled by specialist nurses.
When establishing Danish Quality Database for Inflammatory Bowel Disease(DANIBD) the steering committee agreed that education for the newly diagnosed patients with IBD should be an indicator of quality.
This was a new task and a big challenge for many clinics and also it was unusual for nursing to stand out so clearly in a database.
The tool aims at 1.- supporting the clinics in implementing the new task into clinical practice 2.- securing uniformity in the education in relation to fulfilling the indicator and 3.- improving quality of patient education and nurse consultations to patients with IBD.

Methods
In the IBD group of the Danish Nursing Association(DSR) it was decided to develop a tool that would serve as an inspiration or could be used directly by the clinics.
The tool should ensure that the demands in the indicator was met but should also contain inspiration for other subjects regarding patient education and nurse consultations.
Based on literature and the experience of the group members a list of subjects were made and distributed among the group members for developing slides and notes.
At plenary meetings all this was put together, structured and edited.
In order to get a professional product a collaboration with an art director was established.
Financing was secured by donations from the pharmaceutical industry.

Results
There now are two powerpoint presentations - one for Crohn's disease and one for ulcerative colitis.
each presentation is split in two parts. Part one meets the database and part two is an inspiration for covering other subjects relevant for patient education and nurse consultations.
The presentations encourages the dialogue with the patient and can be customized by the individual clinics or the individual nurses.
The presentations contain additional notes and links to further information.
In order to help implement the tool two nurses from each clinic in Denmark were invited to one day of training in using the tool and in communication.
The presentations were put on the webpage of the IBD group from where it can be downloaded and used by everyone interested.

Conclusion
Developing a quality indicator within the database has started an engaging process focusing on the patient and on improving nursong for patients with IBD.
It is expected that the tool will help support and empower patients in their lives with IBD.
N27 Group meetings for adolescents with IBD: results of a survey on patients’ interests
Authors: Gigante S , Cerizza A , Pozzi K , Comoretto R I , Martinato M 
Published: January 2024

Abstract

Background
The increase in both the incidence and prevalence of IBD, especially in people under 21 years of age1,2,3 outlines new issues to be considered in caring for these patients, like the psychosocial effects on both adolescents and their families, school absences, and developmental delay2. The need for better support to improve their HRQoL4, the embarrassment related to the disease, the anxiety about a sudden appearance of gut symptoms, frequent hospital admissions, and diet restrictions, can lead to social isolation5,6. Group meetings designed to make adolescents and young adults with IBD meet each other and with healthcare professionals (HCP) who are experts in IBD can create a safe environment in which to discuss fears, everyday problems and possible solutions, and any doubt about their condition. This could also provide support, suggestions, and opportunities to peer-compare, further promoting social relationships. This study investigated their willingness to participate in this experience and what they consider important to discuss.

Methods
A focus group involving HCP from a paediatric gastroenterology clinic and interviews with a sample of patients provided the basis on which a clear and easy-to-understand survey was developed concerning interest in the project, willingness to participate, topics to be discussed, and needs of peer relationship. The survey was then performed collecting anonymous data to avoid any kind of potential bias.

Results
Twenty-two patients aged 14 to 19 years completed the survey, showing their poor occasions of discussion about the disease and its related issues with other patients (54.5% of them do not know people with IBD) even if they can talk with their family, HCP and peers outside the hospital or outpatient clinic settings (tab 1). The willingness to participate in a group meeting is higher in the oldest subjects, and they show the highest interest in a peer relationship with patients of the same age and expert HCP. The topics considered more significant are 'nutrition' and 'mood' (described by almost two-thirds of patients) followed by ‘symptoms’ and ‘social life’ (fig 1). The best meeting schedule from the patient's point of view is every 6-8 weeks, with both in-person and virtual participation.

Conclusion
This study provides useful information on the feasibility and willingness of young patients with IBD to participate in such interventions. After the experimental application of group meetings, it will be mandatory to let patients provide feedback on this activity and to assess their effects on patients’ psychosocial well-being.
References (DOI)
1 10.1016/j.crohns.2013.01.010
2 10.1053/j.gastro.2021.12.282
3 10.1016/j.gtc.2023.05.001
4 10.1093/ibd/izy041
5 10.1007/s10880-021-09778-0
6 10.1111/hsc.13755
N37 Fatigue in Japanese patients with Inflammatory Bowel Disease: a comparative study based on a systematic review
Authors: Takai M , Tanaka M , Sakagami K , Ito H 
Published: January 2024

Abstract

Background
Fatigue is a common symptom in patients with inflammatory bowel disease (IBD), often persisting even when the disease is in a state of remission. In addition, it is associated with a diminished quality of life (QOL). However, in Japan, only few studies have focused on fatigue in patients with IBD. The Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-F) scale has shown reliability and validity in assessing fatigue in patients with IBD, and studies using this scale have been conducted worldwide. In this study, we aimed to examine the current state of fatigue among Japanese patients with IBD using the FACIT-F scale and compare these findings with data from the global studies through a systematic review.

Methods
Data from 488 patients with IBD treated at a specialized IBD clinic were analysed. Patient characteristics, such as sex, age, and disease duration, along with FACIT-F scores, height, and weight were included as survey items in the questionnaire administered to patients. Data on the disease names and activities, as determined by the Crohn's disease activity index and partial Mayo score, were obtained from medical records. For international comparison, information on age, sex, country, disease duration, body mass index, and disease activity was extracted from each article and listed alongside FACIT-F scores. We conducted a search on PubMed using the search terms ‘inflammatory bowel disease’ OR ‘Crohn's disease’ OR ‘ulcerative colitis’ AND ‘fatigue’ AND ‘FACIT-F’ OR ‘FACIT’ OR ‘FACIT-fatigue’. After applying our predetermined inclusion criteria, we selected eight studies that met our requirements.

Results
The articles of the systematic review included population sizes ranging from 100 to 1185 patients. Patients’ age varied between the late 30s and early 50s, and the proportion of male patients ranged from 39% to 66%. The duration of disease was approximately 10 years. The proportion of disease names and activities was diverse. The overall mean FACIT-F scores ranged from 38.9 ± 11.0 to 41.6 ± 8.6, while the medians [interquartile ranges] ranged from 30 [22-39] to 41 [35-47]. For each article that presented the FACIT-F scores as means ± standard deviations, the t-tests revealed no statistically significant differences. Overall, the FACIT-F scores were higher (indicating higher QOL) in the remission phase than in the active phase. Additionally, these scores were higher in male patients than in female patients and in patients with ulcerative colitis than in those with Crohn’s disease. These findings were consistent across all countries included in this study.

Conclusion
The FACIT-F scores of Japanese patients with IBD demonstrated a similar trend to those of other countries.