bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of tacrolimus and cyclosporine treatment on metabolic syndrome and cardiovascular risk factors after renal transplantation: a meta-analysis
Authors: Xue Wenrui , Zhang Qiang , Xu Yue , Wang Wei , Zhang Xiaodong , Hu Xiaopeng 
Published: January 2024

Background
The therapeutic success of renal transplantation has been largely attributable to the development of effective and balanced immunosuppressive treatment regimens. This study provides a meta-analysis of a series of randomized controlled trials that compared the effects of tacrolimus and cyclosporine on metabolic syndrome (MetS) and cardiovascular risk factors after renal transplantation.

Methods
We searched various electronic databases and bibliographies, including MEDLINE, the Cochrane Central Register of Controlled Trials, and EMBASE, for relevant studies published prior to October 2012.

Results
Our meta-analysis included five randomized controlled trials that examined a total of 923 patients. The tacrolimus group and the cyclosporine group exhibited no significant differences in MetS incidence after renal transplantation; risk ratio (RR): 1.06, 95% confidence interval (CI): 0.73–1.55, P=0.76. Cyclosporine treatment was associated with a higher incidence of hyperlipidemia (RR: 0.50, 95% CI: 0.39–0.64, P <0.01). Although there were no statistically significant differences, cyclosporine treatment was associated with a higher incidence of hypertension (RR: 0.91, 95% CI: 0.83–1.00, P=0.06) after renal transplantation compared to tacrolimus treatment, and tacrolimus treatment was associated with a higher incidence of diabetes after renal transplantation (RR: 1.79, 95% CI: 0.98–3.27, P=0.06) compared to cyclosporine treatment.

Conclusions
Compared to tacrolimus treatment, cyclosporine treatment was associated with a higher incidence of hyperlipidemia. Future large-scale studies are expected to be conducted to further confirm our findings.
Association between interferon gamma receptor 1 -56C/T gene polymorphism and tuberculosis susceptibility: a meta-analysis
Authors: Wang Wei , Ren Weicong , Zhang Xuxia , Liu Yi , Li Chuanyou 
Published: January 2024

Background
Genetic variations in the interferon-gamma (IFN-γ) receptor 1 gene (IFNGR1) may contribute to tuberculosis (TB) risk in different populations. Many studies have investigated the relationship between IFNGR1 56C/T polymorphism and the susceptibility to TB, but have yielded conflicting results. A comprehensive meta-analysis is needed to provide a more accurate estimation of the relationship between them.

Methods
A literature search based on a combination of manual and computer-based methods was conducted on four English databases (PubMed, Science Direct, SpringerLink, and EBSCO) and three Chinese databases (Wanfang, CQVIP, and Chinese National Knowledge Infrastructure databases). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using either the fixed-effects model or the random-effects model for different genetic models based on the heterogeneity examination.

Results
A total of six studies comprising 1 497 confirmed TB cases and 1 802 controls were included in this meta-analysis. Overall, no significant association was observed between IFNGR1 -56C/T polymorphism and TB susceptibility (C vs. T, OR=0.90, 95% CI 0.69–1.17; CC vs. TT, OR=0.87, 95% CI 0.65–1.18; TC vs. TT, OR=1.031, 95% CI 0.872–1.219; CC+TC vs. TT, OR=0.89, 95% CI 0.64–1.26; CC vs. TC+TT, OR=0.92, 95% CI 0.66–1.29). In subgroup analysis, a significant association was found in the dominant model (CC+TC vs. TT, OR=1.24, 95% CI 1.02–1.51) in Africans, but not in Asians or Caucasians.

Conclusions
Our meta-analysis did not provide enough powerful evidence to identify a significant association between IFNGR1 -56C/T polymorphism and TB susceptibility in the overall population. In subgroup analysis, it indicates that IFNGR1 -56C/T is possibly associated with increased TB risk in Africans, but not in Asians or Caucasians. However, larger sample size and better-designed case-control studies are needed to validate these findings.
Tea drinking and risk of pancreatic cancer
Authors: Junbao Wei , Long Chen , Xiaodong Zhu 
Published: January 2024

Background
Epidemiologic studies have reported inconsistent results regarding tea consumption and the risk of pancreatic cancer. This study aimed to investigate whether tea consumption is related to the risk of pancreatic cancer.

Methods
We searched Medline, EMBASE, ISI Web of Science, and the Cochrane library for studies published up to November 2013. We used a meta-analytic approach to estimate overall odds ratio (OR) and 95% confidence interval (CI) for the highest versus the lowest tea consumption categories.

Results
The summary OR for high versus no/almost never tea drinkers was 1.04 (95% CI: 0.91–1.20), with no significant heterogeneity across studies (P=0.751; I
2=0.0%). The OR was 0.99 (95% CI: 0.77–1.28) in males and 1.01 (95% CI: 0.79–1.29) in females. The OR was 1.07 (95% CI: 0.85–1.34) in Asian studies, 1.05 (95% CI: 0.84–1.31) in European studies, and 0.98 (95% CI: 0.72–1.34) in the US studies. The OR was 0.87 (95% CI: 0.69–1.10) without adjustment for a history of diabetes and 1.16 (95% CI: 0.97–0.39) after adjustment for a history of diabetes. The OR was 0.90 (95% CI: 0.72–1.12) without adjustment for alcohol drinking and 1.16 (95% CI: 0.96–1.39) after adjustment for alcohol drinking. The OR was 0.97 (95% CI: 0.76–1.25) without adjustment for BMI and 1.07 (95% CI: 0.87–1.31) after adjustment for BMI.

Conclusion
This systematic meta-analysis of cohort studies dose not provide quantitative evidence that tea consumption is appreciably related to the risk of pancreatic cancer, even at high doses.
Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue microarray immunostaining
Authors: Ma Ding , Yang Bing , Zhou Zhe , Pan Dongliang , Zhang Xianghua 
Published: January 2024

Background
The pathogenesis of benign prostatic hyperplasia (BPH) has been widely studied, and several biomarkers are known to play roles in its development. This study aimed to investigate the possible role of cysteine-rich protein 61 (CYR61), vascular endothelial growth factor (VEGF), androgen receptor (AR), interleukin-6 (IL-6), cytochrome c, caspase-3, and proliferating cell nuclear antigen (PCNA) in the clinical progression of BPH.

Methods
Tissue specimens from 96 BPH cases who underwent transurethral resection of the prostate were processed and transferred to tissue microarrays. Patient age, prostate volume, serum prostate-specific antigen (PSA) level, and International Prostate Symptom Score (IPSS) of all BPH cases were collected before surgery. The expression of CYR61, VEGF, AR, IL-6, cytochrome c, caspase-3, and PCNA was examined by immunostaining in the BPH specimens, and any possible correlation between the different biomarkers and risk factors for BPH clinical progression was analyzed.

Results
The expression of CYR61, VEGF, AR, IL-6, cytochrome c, caspase-3, and PCNA in the BPH cases was 68.8% (66/96), 77.1% (74/96), 43.8% (42/96), 31.3% (30/96), 35.4% (34/96), 56.3% (54/96), and 29.2% (28/96), respectively. The expression of both CYR61 and VEGF was positively correlated with patient age, prostate volume, and serum PSA level (P <0.05). Furthermore, cytochrome c and caspase-3 expression were inversely related to prostate volume (P <0.05), and AR expression was positively related to serum PSA level (P <0.05).

Conclusion
CYR61 and VEGF expression might serve as biomarkers for predicting the clinical progression of BPH due to effects on stromal cell proliferation and angiogenesis.
Dynamic long-term microstructural and ultrastructural alterations in sensory nerves of rats of paclitaxel-induced neuropathic pain
Authors: Yuan Wu , Jun Li , Junfei Zhou , Yi Feng 
Published: January 2024

Background
Paclitaxel, as a first line anti-neoplastic compound, frequently produces long-term pain after tumors have been treated. Clinical manifestations are varied and non-specific. Pathology of the nervous system during the development of the neuropathic pain is unclear. Thus, early diagnosis and treatment is often unsatisfying for patients. This study aimed to promote considerate understanding of the structural alteration of sensory nerves.

Methods
All rats were simply randomized into 3 groups: paclitaxel group, vehicle group and saline group. An established rat model of paclitaxel-induced peripheral neuropathy (2 mg/kg) was chosen for our research, behavior tests were operated during the procedure of 56 days. All rats were sampled on days 0, 3, 7, 28 and 56. The hind paw plantar skin, sciatic nerves, dorsal root ganglion and attached fibers, and lumbar spinal cord were processed for light and electron microscopy. The differences among 3 groups were analyzed with one-way analysis of variance (ANOVA).

Results
We affirmed that paclitaxel-induced mechano-allodynia and mechano-hyperalgesia occured after a 3-7-day delay, and this pain peaked at day 28 and persisted to day 56. Paclitaxel and vehicle treatment both evoked thermalhyperalgesia. Paclitaxel-induced axonal and myelin sheath degeneration was evident. At days 3 and 7, significant increases in atypical mitochondria in both myelinated axons and C-fibers of paclitaxel-treated nerves indicated that injured mitochondria correlated to specific paclitaxel-induced neuropathic pain, and the abnormity sustained till day 56. Microtubule was unaffected in myelinated axons or C-fibers in paclitaxel- or vehicle-treated rats. Significant increase of G ratio was evident with paclitaxel injection at days 7 and 28.

Conclusion
Our research suggests a causal role for axonal degeneration, abnormalities in axonal mitochondria, and structural modification of axonal microtubules in paclitaxel-induced neuropathic pain, and the abnormal mitochondria could be connected to the chronic neuropathic pain.
Ischemic postconditioning alleviates lung injury and maintains a better expression of aquaporin-1 during cardiopulmonary bypass
Authors: Cheng Chi , Li Shanshan , Wang Yong , Chen Song , You Lu , Zhang Hong 
Published: January 2024

Background
It has found that ischemic postconditioning (IPO) might decrease pulmonary ischemia/reperfusion (I/ R) injury, which is one of the main reasons of lung injury caused by cardiopulmonary bypass (CPB). It was found that aquaporins (AQPs) play a role in the maintenance of fluid homeostasis. But it is still unclear whether IPO influences the expression of aquaporin-1 (AQP1). This study was designed to investigate whether IPO can reduce CPB-related lung injury and affect the expression of AQP1 of lungs.

Methods
Twelve healthy dogs were divided into control group (C group) and ischemia postconditioning group (IPO group). CPB procedures were implemented. Ten minutes later, the left pulmonary artery was separated and blocked. Postconditioning consisted of two cycles of 5-minute pulmonary artery reperfusion/5-minute reocclusion starting at the beginning of reperfusion. The 2×4 cm tissues of both sides of pulmonary apex, superior, middle and inferior lobe were taken before CPB (T1), before occlusion and reopening of left pulmonary artery (T2, T3), and 2 hours after CPB (T4). Samples were used to evaluate lung injury degrees and to detect the expression of AQP1. At T1 and T4, blood was collected from femoral artery to calculate pulmonary function.

Results
At T4, each pulmonary function showed significant deterioration compared with T1. Lung injury could be found at the onset of CPB. However, the expression of AQP1 decreased and wet to dry weight ratio (W/D) increased after T2. In the left lung of C group, the worst pulmonary function and structures were detected. The slightest changes were discovered in the right lung of C group. A close relationship between W/D and lung injury score was found. The lung injury score was negatively related with the expression of AQP1. It was found that the expression of AQP1 was negatively connected with W/D.

Conclusions
In dog CPB models, lung injury induced by CPB was related with down regulated expression of AQP1. AQP1 is believed to be involved in the mechanisms of lung ischemia/reperfusion (I/R) injury caused by CPB. IPO increases the expression of AQP1, provides a protective effect on lung suffering from CPB, and alleviates CPB-related lung injury.
Progress in genotyping of Chlamydia trachomatis
Authors: Xia Yong , Xiong Likuan 
Published: January 2024

Objective
To review the common genotyping techniques of Chlamydia trachomatis in terms of their principles, characteristics, applications and limitations.

Data sources
Data used in this review were mainly from English literatures of PubMed database. The search terms were “Chlamydia trachomatis” and “genotyping”. Meanwhile, data from World Health Organization were also cited.

Study selection
Original articles and reviews relevant to present review's theme were selected.

Results
Different genotyping techniques were applied on different occasions according to their characteristics, especially in epidemiological studies worldwide, which pushed the study of Chlamydia trachomatis forward greatly. In addition, summaries of some epidemiological studies by genotyping were also included in this work for reference and comparison.

Conclusions
A clear understanding of common genotyping techniques could be helpful to genotype C. trachomatis more appropriately and effectively. Furthermore, more studies on the association of genotypes of Chlamydia trachomatis with clinical manifestations should be performed.
Hydrogen sulfide defends against the cardiovascular risk of Nw-nitro-L-argininemethyl ester-induced hypertension in rats via the nitric oxide/endothelial nitric oxide synthase pathway
Authors: Ji Wenqiang , Liu Shangyu , Dai Jing , Yang Tao , Jiang Xiangming , Duan Xiaocui , Wu Yuming 
Published: January 2024

Background
Dyslipidemia caused by liver injury is a significant risk factor for cardiovascular complications. Previous studies have shown that hydrogen sulfide (H2S) protects against multiple cardiovascular disease states in a similar manner as nitric oxide (NO), and NO/endothelial nitric oxide synthase (eNOS) pathway is the key route of NO production. The purpose of this study was to investigate whether H2S can ameliorate the high blood pressure and plasma lipid profile in Nw-nitro-L-argininemethyl ester (L-NAME)-induced hypertensive rats by NO/eNOS pathway.

Methods
Thirty-six 4-week old Sprague-Dawley (SD) male rats were randomly assigned to 6 groups (n=6): control group, L-NAME group, control + glibenclamide group, control + NaHS group, L-NAME + NaHS group, and L-NAME + NaHS + glibenclamide group. Measurements were made of plasma triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (CHO), glutamic-pyruvic transaminase (ALT) levels after 5 weeks. Then measurements of NO level and proteins expression of eNOS, P-eNOS, AKT, P-AKT were made in liver tissue.

Results
After 5 weeks of L-NAME treatment, the blood pressure, plasma TG ((1.22±0.12) mmol/L in L-NAME group vs. (0.68±0.09) mmol/L in control group; P <0.05) and LDL ((0.54±0.04) mmol/L in L-NAME group vs. (0.28±0.02) mmol/L in control group; P <0.05) concentration were significantly increased, and the plasma HDL ((0.26±0.02) mmol/L in L-NAME group vs. (0.69±0.07) mmol/L in control group; P <0.05) concentration significantly decreased. Meanwhile the rats treated with L-NAME exhibit dysfunctional eNOS, diminished NO levels ((1.36±0.09) mmol/g protein in L-NAME group vs. (2.34±0.06) mmol/g protein in control group; P <0.05) and pathological changes of the liver. H2S therapy can markedly decrease the blood pressure ((37.25±4.46) mmHg at the fifth week; P <0.05), and ameliorate the plasma TG ((0.59±0.06) mmHg), LDL ((0.32±0.04) mmHg), and HDL ((0.46±0.03) mmHg) concentration in L-NAME + NaHS group (all P <0.05). H2S therapy can also restore eNOS function and NO bioavailability and attenuate the pathological changes in the liver in L-NAME-induced hypertensive rats.

Conclusion
H2S protects the L-NAME-induced hypertensive rats against liver injury via NO/eNOS pathway, therefore decreases the cardiovascular risk.
Güncel Veriler Işığında Tlos Antik Kenti Tiyatrosu ve Meclis Binası Yapı Kompleksi
Authors: Korkut Taner , Uygun Çilem , Özdemir Bilsen 
Published: January 2024

Lykia Bölgesi sınırları içerisinde yer alan Tlos Antik Kenti Akdağlar’ın batı yamacında, Eşen Vadisi’ne hâkim bir noktada konumlanmıştır. Kentin kuzeyinde Araxa, kuzeydoğusunda Oinoanda, güneyinde Xanthos, güneybatısında Pınara ve batısında Telmessos antik yerleşimleri bulunmaktadır. 19. yüzyıl seyyahları tarafından ilk kez keşfedilen kentte 20. yüzyıl sonlarında başlayan yüzey araştırmaları ve kazı çalışmaları, bölgenin yerleşim tarihçesinin Yunan mitolojisine dayandırılan kuruluş hikayesinden daha erkene uzandığını ortaya koymuştur. Kent merkezinde Neolitik Dönem’den Osmanlı Dönemi’ne kadar kesintisiz süren bir yerleşim kronolojisi izlenmektedir. Uzun soluklu yerleşim sürecinde engebeli topografyanın da etkisiyle devşirme malzeme kullanımı artmış ve girift bir mimari plan uygulanmıştır.
Bu çalışmada, kentin önemli kamu yapılarından biri olan tiyatroda gerçekleştirilen güncel araştırmalardan elde edilen sonuçlar yapının mimari evreleri ve kentin şehircilik anlayışı çerçevesinde yorumlanmıştır. Kuzey ve güney analemmadaki kazı çalışmaları sonrasında tiyatronun planı yenilenmiş ve Erken Roma İmparatorluk Dönemi kullanım evresine ait bir çeşme yapısı açığa çıkartılmıştır. Makale kapsamında değerlendirilen bir diğer yapı ise kentte şimdiye kadar lokasyonu yapılamayan bouleuterion ve prytaneion işlevli olarak kullanıldığı düşünülen mekânlardır. Akropolün doğu yamacında konumlanan yapı iki büyük mekândan oluşur ve Bizans Dönemi’nde sur duvarı içerisine entegre edilmiştir. Kazı çalışmaları sonrasında Helenistik Dönem’de inşa edilen ve MS 4. yüzyıla kadar kullanılan, nişli cephe düzenlemesiyle özgün mimari plana sahip görkemli bir yapı kompleksi açığa çıkartılmıştır.
Yoga for Health and Well-Being in Nursing Students: An Integrative Review
Authors: Ford Jodie 
Published: January 2024

Background:
Undergraduate nursing students currently face unprecedented challenges and experience suboptimal health and well-being. Transformative changes are necessary within nursing education curricula. This integrative review describes the current literature on yoga for health and well-being in nursing education for use by educators.

Method:
The framework by Whittemore and Knafl guided this review. The electronic database search included CINAHL Complete, MEDLINE, ProQuest, PubMed, and Scopus.

Results:
Seventeen articles were identified for inclusion.

Conclusion:

This review provides important strategies for nursing educators to use to improve the health and well-being of undergraduate nursing students. Yoga is a feasible, evidence-based intervention that can be implemented to support students and meet recommendations set forth by nursing organizations. Findings also indicate yoga is an effective tool for promoting positive changes in this population. There are opportunities for educators to further explore the benefits of yoga for those entrusted with the profession's future.

[
J Nurs Educ
. 2024;63(1):17–23.]
Keratoconus Treatment Using Femtosecond Laser–Assisted Innovative Intracorneal Ring–Supported Graft Surgery: A Pilot Investigation
Authors: Jadidi Khosrow , Alió Jorge L. , Mosavi Seyed Aliasghar , Nejat Farhad , Aghamolaei Hosein , Pirhad Shiva , Dianat Mohamad Hadi 
Published: January 2024

Purpose:
To investigate clinical manifestations and response to a revision in the intrastromal corneal ring and implantation technique for the treatment of severe keratoconus at two private clinics in Iran.

Methods:
This prospective, non-comparative clinical study included 6 eyes from 6 patients treated with a new innovative sutureless ring-supported graft insertion technique. Refractive, topographic, corneal biomechanical, and anterior aberrometry outcomes were analyzed during the 6-month follow-up. Secondary variables included corneal stiffness and confocal microscopy.

Results:

No intraoperative and postoperative complications occurred. Six months after implantation of the RinGraft, the ring was centered at the pupil reflex, the eye was white and quiet, and the graft was clear. The mean topographic keratometry values decreased significantly postoperatively (
P
= .025). Additionally, corneal stiffness increased significantly postoperatively (
P
= .004). Anterior and posterior corneal aberrometry data collected over a 5-mm diameter revealed a significant decrease in higher order aberrations, spherical aberration, primary coma, and trefoil 6 months after surgery (
P
= .019). Intraocular pressure changes were significantly greater than before surgery (
P
= .006). Uncorrected distance visual acuity increased from 0.96 ± 0.52 logMAR preoperatively to 0.71 ± 0.22 logMAR postoperatively (
P
= .078). No statistically significant change was found in corrected distance visual acuity (
P
= .0221)

Conclusions:
Excellent structural support and stability of the cornea were observed immediately postoperatively and 6 months after RinGraft insertion. Considering the corneal instability and asymmetry, it appears to be a possible and safe therapy option for keratoconic eyes that can be performed easily.

[
Journal of Refractive Surgery Case Reports.
2024;4(1):e1–e10.]
Late-onset Diffuse Lamellar Keratitis in the Context of Conjunctivitis Related to COVID-19: Case Report
Authors: Shetty Akaanksh , Leal Sebastian , Mulpuri Lakshman , Tonk Rahul 
Published: January 2024

Purpose:
To report a case of diffuse lamellar keratitis (DLK) occurring 23 years after laser in situ keratomileusis (LASIK), coinciding with a recent diagnosis of conjunctivitis related to coronavirus disease 2019 (COVID-19) .

Methods:
A 47-year-old woman had LASIK in 2000 and developed conjunctivitis related to COVID-19 in March 2022. In February 2023, she presented with 5 days of decreased vision (corrected distance visual acuity 20/25), photophobia, and glare in her right eye. She was diagnosed as having stage I DLK in the right eye based on corneal inflammatory infiltrates in the peripheral flap interface.

Results:
Topical steroids improved the patient's symptoms and resolved the inflammatory infiltrates within 2 months with a final corrected distance visual acuity of 20/20.

Conclusions:
This report describes a rare case of DLK occurring more than 20 years after LASIK. It is important to consider DLK even outside of the early postoperative period after LASIK or another lamellar interface–based procedure. In this case, conjunctivitis related to COVID-19 may have played a role in immune dysregulation and the development of DLK.

[
Journal of Refractive Surgery Case Reports.
2024;4(1):e11–e14.]
A Decisive Phase of Intense Diplomatic Negotiations between the Mamluk Sultanate and Western Powers (the Crown of Aragon, and the Republics of Genoa and Venice), 1288–1293/AH 687–692
Authors: Coulon Damien 
Published: January 2024

The end of the Latin States of the East in 1291 was a decisive stage in the crusades and in the relations between Christians and Muslims, as historiography has long emphasised. However, in the context of this major conflict, some Western powers—the Republics of Genoa, Venice and the Crown of Aragon—managed to define compromise and exchange agreements of various kinds, which were quite remarkable and which for a long time have gone unnoticed, despite their great originality. This article focuses on the negotiations and the audacious double peace treaty concluded between the Aragonese and Mamluk rulers in 1290 and 1293. It draws on the remarkable archival documentation that has survived on this subject, in particular the Arabic and Catalan versions of the treaty, which has come to new attention thanks to recent developments in the historiography of diplomatic relations in the Middle Ages, both in the Christian West and in the Muslim Levant.