bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of combined training with different intensities on cardiac structure and function in patients with type 2 diabetes: a randomised controlled trial
Authors: he jianghua , wang yang , zhang jianhong , gao can , ma yahong , Dong Chen , Chen Liang 
Published: November 2023

Abstract
Background
Regular exercise is a well-accepted strategy to improve cardiovascular system function in patients with type 2 diabetes mellitus. The results of trials assessing the impact of exercise training on cardiac function in T2DM have been inconsistent. Whether combined exercise training improve subclinical cardiac dysfunction in people with T2DM, however, is not known. Therefore, the purpose of this study was to investigate the effects of high-intensity interval training (HIIT) combined with resistance training (RT) and moderate-intensity continuous training (MICT) combined with RT on cardiac structure and function in patients with type 2 diabetes. The impact of HIIT + RT and MICT + RT on cardiorespiratory fitness and metabolic control was also investigated.
Methods
54 patients who met the inclusion criteria were randomly assigned to the HIIT + RT group, MICT + RT group, and control group (CG). With 18 participants in each group, for 12 weeks, three times per week exercise intervention. Patients underwent echocardiographic cardiac function and structure, metabolic and clinical evaluation at baseline and 3 months.
Results
(1) There was a significant difference between groups for changes on VO2peak. Greater increases on VO2peak were achieved for HIIT + RT in comparison to CG group, with significant difference between HIIT + RT and MICT + RT. VO2peak significantly increased for both HIIT + RT and MICT + RT (P༜0.01). (2) After 12 weeks of intervention, HIIT + RT significantly changed EF, LVPWT, LVEDD and LVESD and LVM (P༜0.01). MICT + RT only had significant effects on EF, LVPW (P༜0.01), and LVM (P༜0.05). Compared with CG, HIIT + RT significantly improve EF, LVEDD (P༜0.01), and LVM (P༜0.05) in T2DM patients. Compared with MICT + RT, HIIT + RT was more effective in improving LVEDD (P༜0.05).
Conclusions
(1) 12 weeks of HIIT + RT and MICT + RT significantly improved body weight and blood glucose control in T2DM patients, which would be beneficial to reduce the risk of cardiovascular disease in T2DM patients. (2) 12 weeks of HIIT + RT and MICT + RT significantly improved peak oxygen uptake and cardiac structure and function in T2DM patients; However, HIIT + RT was more effective in improving cardiopulmonary fitness and cardiac structure and function in T2DM patients.
Tablet-based cognitive training as an early intervention tool for children with autism spectrum disorder
Authors: Cai Zhaona , Li Jiaxiao 
Published: November 2023

Abstract
Background In recent years, with the development of the digital society, tablet/computer-based digital therapies have gradually been applied to assist in the learning, cognition, and social communication of children with Autism Spectrum Disorder (ASD). This will help address the limitations of offline interventions and provide more diverse treatment options for children with autism. In this article, we describe the basic framework of an innovative digital cognitive intervention software developed for toddlers and preschool children with ASD based on the principles of Applied Behavior Analysis (ABA). Additionally, we conducted a preliminary test study to explore the usage and attitudes of Chinese children with autism and their parents towards digital cognitive therapy. Methods In the preliminary test study, 6 Chinese children with ASD aged 3 to 6 were first recruited for a six-week usage test, and the patterns and performance of digital-assisted therapy software used by ASD children were quantitatively analyzed. Subsequently, 12 more ASD children aged 3–6 were recruited for a 3-month test study. A parent questionnaire was distributed after the test and a qualitative analysis of usage and primary caregivers' attitudes towards the digital software was conducted. Results The results of the training data preliminary confirmed the feasibility of the developed cognitive intervention software and the effectiveness of using the software for cognitive skills training in Chinese children with ASD. At the same time, the results of questionnaire interviews with 18 parents of autistic children who were treated with the cognitive intervention software also showed positive outcomes. Conclusion The autism digital intervention tool used in this study is feasible and has certain potential benefits. In the future, formal clinical control studies need to be conducted to recruit subjects from a wide range of backgrounds to further validate the effectiveness of this digital cognitive intervention software.
Evaluation of effect of phytoremediation of heavy metal pollution in farmland soils around a lead-zinc mine, Southwest China
Authors: Liu Wenting , Li Ming , Tamehe Landry Soh , Hong Tangyu , Shi Yujiao , Huang Lishan 
Published: November 2023

Abstract
Environmental pollution by heavy metals in mining areas is a major concern worldwide since it affects surrounding farmland soils as well as the food chain and human health. Phytoremediation is amongst the low cost and environment friendly method proposed to clean up heavy metals from contaminated soils. In this study, we investigate the farmland soils of the Sidi village in Xingping Town, Yangshuo County, Guilin City, Guangxi Zhuang Autonomous Region, which were contaminated by nearby abandoned lead-zinc mine. The contents of heavy metals (As, Cd, and Pb) in these soils have severely exceeded the threshold local values according to the China national standard GB15618-2018. It is therefore urgent to carry out effective remediation of soils polluted by heavy metals to ensure safety of crop production in farmland soils of this region. Hyperaccumulator plants and plant barrier were adopted to reduce the content of heavy metals in soils of slightly polluted areas. The contents of As, Cd, and Pb in soils of moderately polluted areas were reduced by using passivator combined with low heavy metal accumulation crops. Rotation of oilseed rape and oil sunflower has continuously prevented metal pollution in heavily polluted areas. After 15 months of remediation, the pH values of soils in all polluted areas were gradually changing from weakly acidic to near-neutral pH, which met the requirements for crop planting. This study provides a scientific reference to apply remediation methods for polluted soils by heavy metals for the restoration of ecological environment of farmland soils around lead-zinc mine.
The Causal Relationship between Chronic Obstructive Pulmonary Disease and Cardiovascular Diseases: Role of Systemic Inflammation and NF-κB/COX-2 Pathway
Authors: Wu You , Zhang Houwen , Yu Jialin , Cai Wanru 
Published: November 2023

Abstract
Background
Chronic Obstructive Pulmonary Disease (COPD) is a significant global health issue that often coexists with cardiovascular and cerebrovascular diseases. The aim of this study is to investigate the causal relationship between COPD and these diseases, with a focus on the role of systemic inflammation and the NF-κB/COX-2 pathway.
Methods
The Two-Sample Mendelian Randomization (TSMR) approach was used to analyze the genetic correlation between COPD and the risks of ischemic stroke (IS) and acute myocardial infarction (AMI) using data from several large biobanks. In addition, in vivo experiments with ApoE knockout mice and in vitro assays with primary mouse aorta endothelial cells were conducted to explore the role of the NF-κB/COX-2 pathway in COPD-related systemic inflammation.
Results
The MR analysis revealed a significant association between COPD and increased risks of IS (OR: 1.152) and AMI (OR: 1.001). In vivo findings showed exacerbated pulmonary dysfunction and atherogenesis in mice with both COPD and high-fat diet (HFD), with notable histological changes in lung and aortic tissues. Inflammatory markers and lipid profiles were significantly altered in these models. In vitro studies demonstrated that COPD-induced systemic inflammation impaired endothelial cell function. These changes were mitigated by inhibiting the NF-κB/COX-2 pathway.
Conclusions
This study provides strong evidence of a causal link between COPD and an elevated risk of cardiovascular diseases, mediated by systemic inflammation and the NF-κB/COX-2 pathway. These findings highlight the importance of addressing cardiovascular risks in COPD management and suggest that the NF-κB/COX-2 pathway could be a potential therapeutic target for reducing comorbid cardiovascular conditions in COPD patients.
Interactive virtual reality environments and emotions: a systematic review
Authors: Linares-Vargas Benjamin G.P. , Cieza-Mostacero Segundo E. 
Published: November 2023

Abstract

Emotions influence the way we react in different contexts. Virtual Reality (VR) makes it possible to generate environments that can resemble a real experience. These concepts were taken as the basis of the review, focusing on the use of VR on emotions. The search for information was carried out in the Scopus database (179) and other sources of information (17), and the selection criteria were applied to 196 results, such as the user's interaction with the environment and the application of a software development of VR applications, resulting in the analysis of 16 studies. Unity was found to be used in 81.25% of the articles, HTC Vive appears in 37.5% of the research. The minimum time of application of the experience is 1 minute contrasting with the maximum time of 30 minutes. Only theories of emotions were mentioned in 18.75% of the articles, most of the research uses VR to influence users (56.25%) and with the indicators only 1 article coincides with ISO 25000.
Exploring Genetic Testing Requests, Genetic Alterations and Clinical Associations in a Cohort of Children with Autism Spectrum Disorder
Authors: Garrido-Torres Nathalia , Rodríguez Renata Marqués , Alemany-Navarro María , Sánchez-García Javier , García-Cerro Susana , Ayuso María Irene , González-Meneses Antonio , Martinez-Mir Amalia , Crespo-Facorro Benedicto , Ruiz-Veguilla Miguel 
Published: November 2023

Abstract
Several studies show great heterogeneity in the type of genetic study requested and in the clinicopathological characteristics of patients with ASD. Objective: The following study aims, firstly, to explore the factors that might influence professionals' decisions about the appropriateness of requesting genetic testing for their patients with ASD and, secondly, to determine the prevalence of genetic alterations in a representative sample of children with a diagnosis of ASD. Methods: We studied the clinical factors associated with the request for genetic testing in a sample of 440 children with ASD and the clinical factors of present genetic alterations. Results: Even though the main guidelines recommend genetic testing all children with an ASD diagnosis, only 56% of children with an ASD diagnosis were genetically tested. The prevalence of genetic alterations was 17.5%. These alterations were more often associated with intellectual disability and dysmorphic features. There are no objective data to explicitly justify the request for genetic testing, nor are there objective data to justify requesting one genetic study versus multiple studies. Remarkably, only 28% of males were genetically tested with the recommended tests (fragile X and CMA). As expected, children with dysmorphic features and organic comorbidities were more likely to be genetic tested than those without. Previous diagnosis of ASD (family history of ASD) and attendance at specialist services were also associated with Autism Spectrum Disorder Genetically tested GTASD. Conclusions: Our results reflect the need to develop algorithms that could make it possible to offer genetic testing not only to children with intellectual disability and dysmorphic features, but also to the whole ASD population.
Predictive Cross-sectional Study of religiosity, mental immunity, and psychological well-being of diabetes patients in the Kingdom of Saudi Arabia
Authors: Eid Nawal A Al , Arnout Boshra A. , Al-Qahtani Thabet A. , Pavlovic Slavica , AlZahrani Mohammed R. , Abdelmotelab Abdalla S. , Abdelmotelab Youssef S. 
Published: November 2023

Abstract

This predictive cross-sectional study aimed to examine the levels of religiosity, mental immunity, and psychological well-being (PWB) in patients with diabetes, taking into consideration differences due to gender as well as the possibility of predicting the diabetic patients PWB through religiosity and psychological immunity variables. This study was conducted from May 2022 to February 2023 on a random stratified sample of 186 Saudis diagnosed with diabetes. After obtaining the consent of the participants in the study, they answered the scales of religiosity, psychological immunity, and PWB. Means and standard deviations were used to measure the levels of study variables, the t-test to detect differences, and linear regression analysis to validate the predictability of PWB from religiosity and psychological immunity variables. The results indicated average religiosity, psychological immunity, and PWB mean levels. Furthermore, the results indicated statistically significant differences between male and female participants in religiosity, psychological immunity, and PWB in favor of females. No statistically significant differences were found between the groups of patients under 50 years of age and those aged 50 and over in the given variables. However, the findings indicated that psychological immunity was a strong predictor of PWB in diabetic patients. These results confirm the necessity of examining the PWB and psychological immunity of diabetic patients periodically after they start drug treatment as well as the attitudes of health care providers in diabetes care centers who should pay more attention to providing psychological care alongside health care in order to enhance the PWB of diabetes patients, especially for male diabetics.
The impact of economic growth and energy consumption on CO2 emissions in Algeria
Authors: Allali Malika , Mouhadjer Samir 
Published: November 2023

Abstract
Whether there is a relationship between economic growth and energy consumption and the direction of this relationship is of great importance in energy policy decision making in countries where the state plays an active role in energy markets. If there is a relationship from energy to growth, conservative policies such as energy taxes, energy-saving, and energy prices will hurt growth.
This paper attempts to investigate the impact of economic growth and energy consumption on CO2 emissions in Algeria for the period 1990-2100, because energy-related CO2 constitutes over 80% of total emissions, the state energy-related CO2 emission levels provide a good indicator of the relative contribution of individual states to total greenhouse gas emissions.
Our empirical results show that the effect of the independent variables on carbon emissions is heterogeneous across quantities. Energy consumption increases the carbon dioxide emissions, with the strongest effects occurring at different quantities for sample group’s data. But the effects of energy consumption on carbon emissions for developed countries are greater than developing countries. In view of the economic development, developing countries and developed countries present the obvious stage characteristics. The empirical findings are in support of inverted U-shaped curve.
The use of a combined flap in closed-type tympanoplasty
Authors: Komarov M. V. , Dvorianchikov V. V. , Anikin I. A. 
Published: November 2023

Introduction. Cartilage graft has been used in otosurgery since 1959. Cartilage resistance to pressure drops in the tympanic cavity and blood supply deficit in the early postoperative period favorably distinguish it from autofascia. When performing myringoplasty, it is important to create conditions for the formation of a neotympanic membrane that has the same three-dimensional spatial configuration as the native tympanic membrane with full contact of the membrane with the bone tympanic ring and the handle of the malleus. Also, the formation of the neotympanic membrane (myringoplasty) is a key step in tympanoplasty with ossiculoplasty, which ensures not only the restoration of the tightness of the tympanic membrane, but also the contact and proper fixation of the distal part of the prosthesis used to replace the lost elements of the auditory ossicular chain.Objective. Evaluate the effectiveness of closed-type tympanoplasty by using a combined autofascial-autocartilaginous flap.Materials and methods. A study group was formed, including patients who underwent tympanoplasty of types 1–3 according to M. Tos according to the proposed method of using an autofascial-autocartilaginous flap (343 patients), and a comparison group, including patients who underwent type 1 tympanoplasty with using autofascia (54 patients).Results. Long-term anatomical results showed greater stability of the neotympanic membrane formed by the proposed method (2% reperforations). Functional results in the range of speech frequencies had no significant differences. Comparison of functional results in the high frequency range demonstrated a significant advantage of the proposed technique.Conclusion. The conclusion is drawn that the proposed method of forming a neotympanic membrane close in configuration to the native tympanic membrane provides a high functional result with a reduction in the gap in sound conduction between the diseased and healthy ear to 5–10 dB at frequencies of 0.5–16 kHz.
Prevalence of antimicrobial-resistant Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis
Authors: Lyamin A. V. , Zolotov M. O. , Kondratenko O. V. , Maksimova E. A. , Ismatullin D. D. , Bochkareva P. V. 
Published: November 2023

Introduction. Violation of sputum evacuation in patients with cystic fibrosis leads to the persistence of microorganisms. Most often, the microorganisms are isolated from sputum in patients with cystic fibrosis: Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia complex, etc. For the treatment of infections caused by P. aeruginosa, the following groups of antibiotics are used: aminoglycosides, carbapenems, polymyxins, cephalosporins, fluoroquinolones, inhibitor-protected penicillins and fosfomycin.Aim. To the study is to determine antimicrobial resistance in P. aeruginosa isolated from patients with cystic fibrosis.Materials and methods. An analysis of 87 results of sputum, biomaterial from the posterior wall of the pharynx and nose was made.Results and discussion. Biomaterial was taken from the nasal in 4.6% cases, from the posterior pharyngeal wall in 35.6% and sputum in 59.8%. The lowest level of resistance was registered in strains isolated from the nasal cavity. Microorganisms isolated from the posterior pharyngeal wall showed a higher level of antibiotic resistance. The sensitivity data of sputum isolates were similar to the results from the posterior pharyngeal wall. The highest level of resistance was obtained to aminoglycosides (19.3%) and carbapenems (14.8%). In addition, 12.5% of P. aeruginosa isolates were resistant to sodium colistimethate, 10.2% to fluoroquinolones. The lowest level of insensitivity was found to cephalosporins (5.7%) and protected beta-lactams (4.5%). The revealed trend of decreasing sensitivity, in our opinion, is associated with a greater frequency of antibiotic use.Conclusion. Chronic P. aeruginosa infection in patients with CF contributes to a more severe course of the disease and increases the risk of complications.
Differentiated approach to the treatment of infectious and inflammatory pathology of the pharynx and tonsils in adults
Authors: Gurov A. V. , Dubovaya Т. K. , Ermolaev A. G. , Murzakhanova Z. V. , Khalifaeva J. Z. , Klimov A. D. 
Published: November 2023

Introduction. The problem of infectious pathology of the pharynx and tonsils, manifested by sore throat, does not lose relevance. In the absence of indications for systemic antibacterial therapy, the main role of etiotropic treatment passes to topical use of drugs, including in the form of gargling. One of these is hydroxymethylquinoxalindioxide (Dioxidin®), which has recently received a new dosage form.Aim. To present an overview of the efficacy and safety of two dosage forms of Dioxidin® in the treatment of infectious and inflammatory pathology of the pharynx and tonsils.Materials and methods. The results of evaluating the efficacy and safety of 0.1% and 0.025% Dioxidine solutions for oropharyngeal rinsing in the treatment of adult patients with acute tonsillopharyngitis (ATP) or exacerbation of chronic tonsillitis (eCT) obtained during controlled comparative multicenter clinical trials conducted in 2017–2020 were analyzed.Results. By day 9 ± 1 of follow-up, relief of all local signs of inflammation according to pharyngoscopy was observed in 87% of patients with ATP or eCT who used 0.1% solution for rinsing and in 84% of patients with ATP who used 0.025% Dioxidine solution for rinsing. The severity of sore throat, assessed using a visual analog scale, by the specified time decreased by 63 points in the group using 0.1% solution and by 50 points according to the study of the effectiveness of 0.025% Dioxidine. 0.1% Dioxidine solution was more effective than 0.02% nitrofuran solution, and at a concentration of 0.025%, the effectiveness of Dioxidine was comparable to 0.01% benzyldimethyl[3-(myristoylamino)solutionpropyl]ammonium chloride. Both studies demonstrated a high level of safety of the two dosage forms of Dioxidine, which has no statistically significant differences from the safety assessments of comparison drugs.Conclusion. The presented data confirm the high efficacy and safety of 0.1% and 0.025% Dioxidin® solutions and suggest the possibility of implementing a differentiated approach to the treatment of inflammatory tonsillar pathology using two dosage forms of the drug.