bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participant Satisfaction in a Cardiovascular Disease Prevention Intervention for Midlife Black Women
Authors: Jones Holly J. , Kovacic Melinda Butsch , Bacchus Patricia , Almallah Wala’a , Bakas Tamilyn 
Published: October 2023

Background: Midlife Black women suffer disproportionately from cardiovascular disease and are 65% more likely to die following a cardiac event compared with White women. Recruitment and retention of midlife Black women in clinical trials has been historically low. The culturally tailored Midlife Black Women’s Stress Reduction and Wellness (B-SWELL) intervention was codeveloped with the community and designed to lower cardiovascular disease risk in midlife Black women. Objectives: We sought to assess participant satisfaction in the randomized feasibility trial of the B-SWELL intervention. Methods: A feasibility trial comparing the B-SWELL to a wellness intervention was conducted in the winter and spring of 2021 in compliance with pandemic research protocols. An adapted survey tool was used to rate satisfaction with the intervention and its technology using a Likert-type scale (1 [strongly disagree] to 5 [strongly agree]). Survey subscales assessed usefulness, ease, and acceptability of the intervention(s). Results: Randomization yielded no statistical demographic differences (N = 48). Satisfaction for the interventions was high in both the B-SWELL and Wellness intervention groups with mean scores of 4.57 and 4.56, respectively. Mean scores for technology were 4.49 for the B-SWELL and 4.47 for the Wellness group. Subscales were also rated highly. Narrative responses were positively aligned with satisfaction scores. Conclusions: Results support use of cultural adaptation and community participatory methods to develop and deliver interventions targeted to at-risk populations. Culturally adapted interventions designed in collaboration with the community have greater authenticity, increasing the potential for higher recruitment, retention, and participant satisfaction of underrepresented populations. The trial is registered in ClinicalTrials.gov (NCT 04404478).
Hypodontia and Skeletal Malocclusions Among Orthodontic Patients of Kathmandu, Nepal: A Radiographic Study
Authors: Gupta Sanjay Prasad , Rauniyar Shristi 
Published: October 2023

Objective To assess the association between hypodontia and skeletal malocclusions in orthodontic patients. Materials and Methods This cross-sectional study comprised of orthodontic records of 40 hypodontic patients (12 males and 28 females) and 120 non hypodontic patients (58 males and 62 females) as control group matched for gender and age with the study sample who came to the orthodontic department for their treatment were selected. Orthopantamograms were evaluated for hypodontia, whereas lateral cephalogram were traced to determine the cephalometric parameters. The association between different classes of skeletal malocclusion and hypodontia was determined using Pearson’s Chi-square test and the cephalometric parameters between patients with hypodontia and without hypodontia (controls) were assessed using Student’s t-test. Result In hypodontic group, 19 (47.5%) patients had skeletal class II, 18 (45%) patients had skeletal class I, and only 3 (7.5%) patients had skeletal class III malocclusions. Whereas in non-hypodontic group (control group), 86 (53.75%) patients had skeletal class II, 63 (39.38%) patients had skeletal class I, and 11 (6.87%) patients had skeletal class III malocclusions. There was no statistical difference between hypodontia and different skeletal classes of malocclusions ( p = .654). Cephalometric parameters between the control group and hypodontic group did not reveal any significant difference ( p > .05). Conclusion This study did not find any association between different classes of skeletal malocclusions and hypodontia. The cephalometric skeletal parameters were not significantly different in hypodontic and control group. It is suggested that the patients having hypodontia will be evaluated on an individual basis for their treatment.
Climate change and mental health: Global challenges for psychosocial resilience and recovery
Authors: Chiu Lauren 
Published: October 2023

Objective As the greatest global challenge of our time, climate change is not only an ecological crisis but also a humanitarian one. Climate action is a defining opportunity to not only collectively mend ecological health and biodiversity but also to advance psychosocial resilience and social cohesion. This essay aims to understand the interconnectedness between climate change and mental health, as well as explore ways in which this can be transformed into a mobilising force. Conclusions The ramifications of climate change on mental health are complex, and there continues to be expanding knowledge on this through research undertaken out of heightening urgency. With knowledge of this, global recovery will require meaningful and transformative action that addresses the interconnection between climate change, mental health, and social injustice.
Longitudinal Outcomes of Resilience, Quality of Life, and Community Integration in Treatment-Resistant Depression: A Two-Group Matched Controlled Trial
Authors: Wu Chia-Yi , Lee Ming-Been , Huong Pham Thi Thu , Chen I-Ming , Chen Hsi-Chung , Hsieh Min-Hsien 
Published: October 2023

BACKGROUND: Current evidence of nonpharmacological intervention for patients with treatment-resistant depression (TRD) is lacking. AIMS: To examine whether an 8-week nurse-led cognitive-behavioral based group intervention would enhance resilient coping and life quality among community-based patients with TRD. METHOD: The participants were randomly sampled from a cohort of TRD recruited from two general teaching hospitals. The two groups were assessed with multiple outcome measures at baseline (T0); 8-week post-baseline (T1); and at 3, 6, and 9 months after T1 (T2–4). Psychoeducation was nested in the cognitive behavioral group intervention to facilitate discussion. RESULTS: Of the 23 participants (mean age 56 years, 69.6% female) in the experimental group, higher resilient coping and lower mental distress levels at T1 as well as later improved quality of life and community integration at T2–4 were observed compared to the controls across COVID-19 (T3). Overall, the scores of resilience and community integration were higher throughout the four follow-up points of observations for the experimental group. CONCLUSION: The findings indicated that an 8-week nurse-led cognitive-behavioral based group intervention may enhance the TRD patients’ resilient coping and mental distress levels while providing the potentials for community reintegration after mental health psychoeducation engagement. It is imperative for the nurses caring for patients with TRD to extend from clinical-based intervention to community-based self-care approach, with the importance of short-term stress management and healthy lifestyle development highlighted during the community reintegration trajectory.
Mediation of Parental Aggravation in the Association Between ADHD Severity and Electronic Media Use: A National Survey of Children’s Health Study
Authors: Han Jennifer , Koser Karen , Mamey Mary Rose , Vanderbilt Douglas L. , Schonfeld David J. , Yin Larry , Deavenport-Saman Alexis 
Published: October 2023

Objective: To determine whether the association between ADHD severity and electronic media use was mediated by parental aggravation. Methods: This was a retrospective analysis from the 2016 to 2017 National Survey of Children’s Health (NSCH) involving children ages of 3 to 17 years with parent-reported ADHD ( n = 5,930). Path analyses were used to model the relationships between ADHD severity with parental aggravation (PA) as a mediator, and electronic device (ED) and television (TV) use as outcomes, controlling for covariates. Results: Parental aggravation mediated the relationship between ADHD severity and ED use and TV use (indirect effects: β = .02, p < .001; β = .01, p = .004). When stratified by age, the mediation effect between ADHD and ED use remained significant for adolescents and school-age children, and mediation between ADHD and TV use remained significant only for adolescents. Conclusion: These findings suggest a need to develop targeted interventions to address PA and manage excessive electronic media use in children with moderate/severe ADHD.
Evaluation of endoscopic-assisted feline lateral bulla osteotomy: a cadaveric study
Authors: Enright Dory , Cole Grayson , Hatfield Jordan 
Published: October 2023

Objectives The aims of the study were to investigate if feline middle ear anatomy can be visualized using endoscopy via a lateral bulla approach and to determine if scope-assistance increases rates of successful entry into the hypotympanum during feline total ear canal ablation and lateral bulla osteotomy (TECA-LBO). Methods A total of 13 feline cadaver heads underwent CT to confirm the absence of pre-existing middle ear disease. For each head, an electronic coin toss was used to determine which ear would undergo endoscope-assisted TECA-LBO; a traditional TECA-LBO without the use of the scope was performed on the contralateral side. In endoscope-assisted procedures, a 1.9 mm scope was intermittently inserted into the tympanic bulla via a lateral bulla approach and used to identify middle ear structures, visualize the bony septum and confirm entry into the hypotympanum. After the bilateral TECA-LBO, the cadaver heads were imaged again and assessed for evidence of entry through the septum. Results Soft tissue and osseus structures of the middle ear were readily visualized with a 1.9 mm scope. Success rates for entry into the hypotympanum were high between both endoscope-assisted and traditional procedures, with entry confirmed for 12/13 ears in each group. Conclusions and relevance Endoscope assistance can facilitate the identification and examination of middle ear structures but does not appear to increase the success rate of entry into the hypotympanum during feline TECA-LBO, as entry through the bony septum was consistently accomplished even without scope-assisted visualization. Alternative benefits to scope assistance may exist, and future studies to elucidate its impact on rates of intraoperative trauma to middle ear structures are indicated.
Secretory Breast Carcinoma: Report of Two Cases and Literature Review
Authors: Mouadin Amal , Tahiri El Ousrouti Laila , Boukansa Sara , Hammas Nawal , Chbani Laila , El Fatemi Hinde 
Published: October 2023

Secretory Breast Carcinoma (SBC) is a rare subtype of breast cancer, predominantly affecting young women, and characterized by hormone receptor-negative and HER2-negative tumors with distinctive histological features, including secretory droplets within tumor cells. This article presents 2 unique cases of SBC, Case 1 involving a 42-year-old woman with triple-negative mammary carcinoma later diagnosed with triple-negative secretory carcinoma, and Case 2 featuring a 48-year-old woman with poorly differentiated adenocarcinoma subsequently identified as invasive mammary carcinoma of secretory type. Both cases received diverse treatment regimens, incorporating surgery, chemotherapy, radiotherapy, and hormone therapy. The importance of accurate diagnosis and the need for further research to optimize the management of this rare breast cancer subtype are emphasized. Raising awareness of SBC and reporting additional cases can enhance understanding and improve patient outcomes. Additionally, the integration of clinical, radiological, and histopathological findings, alongside specific molecular markers like S-100 and mammaglobin, is crucial for accurate SBC diagnosis. Given the lack of established guidelines for SBC management, collecting additional cases can aid in defining a more effective strategy for diagnosis, monitoring, and treatment, ultimately contributing to advancements in the field. Herein, we report 2 cases of this rare disease that were diagnosed and treated in our institution.
Efficacy of Transdermal Dihydrotestosterone and Testosterone Enanthate for Penile Augmentation in Patients With Idiopathic Micropenis: A Comparative Randomized Study
Authors: Karrou Marouan , Messaoudi Najoua , Assarrar Imane , Alla Achwak , Rouf Siham , Latrech Hanane 
Published: October 2023

Objectives: Our study aimed to compare the efficacy of transdermal dihydrotestosterone and testosterone enanthate in treating idiopathic micropenis. Patients and methods: It’s a comparative randomized study of 49 patients with idiopathic micropenis who are followed up in the Endocrinology-Diabetology and Nutrition Department of Mohammed VI University Hospital Center of Oujda, Morocco. The study was conducted from December 2019 to April 2021. All patients received a clinical examination including measurement of penis size before and after hormonal treatment. The patients were divided into two random groups, each group received a different drug, the first arm was treated with transdermal dihydrotestosterone (27 patients) and the second arm was treated with testosterone enanthate (22 patients). The Trial registration number was researchregistry7745. Results: The majority of the patients were children. The mean age was 9.7 ± 4.4 years. In the first arm, the mean penile size increased from −2.42 SD to −0.7 SD with a gain of 2.37 cm on average. In the second arm, the mean size increased from −2.48 SD to −0.69 SD, with a gain of 1.82 cm on average. The increase in penile size in the first arm was significantly greater than in the second arm ( P = .008). No side effects were detected in both arms. Discussion and conclusion: In the present study, we demonstrated the superiority of transdermal DHT compared to injectable exogenous testosterone in the treatment of idiopathic micropenis. According to the age subgroups, there was no significant difference between the 2 treatments in each age group.
Diroximel fumarate in patients with relapsing–remitting multiple sclerosis: Final safety and efficacy results from the phase 3 EVOLVE-MS-1 study
Authors: Singer Barry A , Arnold Douglas L , Drulovic Jelena , Freedman Mark S , Gold Ralf , Gudesblatt Mark , Jasinska Elzbieta , LaGanke Christopher C , Naismith Robert T , Negroski Donald , Oh Jiwon , Hernandez Perez Miguel Angel , Selmaj Krzysztof , Then Bergh Florian , Wundes Annette , Ziemssen Tjalf , Castro-Borrero Wanda , Chen Hailu , Levin Seth , Scaramozza Matthew , Shankar Sai L , Wang Ting , Wray Sibyl 
Published: October 2023

Background: Diroximel fumarate (DRF) is approved for adults with relapsing–remitting multiple sclerosis (RRMS) in Europe and for relapsing forms of MS in the United States. DRF and dimethyl fumarate (DMF) yield bioequivalent exposure of the active metabolite monomethyl fumarate. Prior studies indicated fewer gastrointestinal (GI)-related adverse events (AEs) with DRF compared with DMF. Objective: To report final outcomes from EVOLVE-MS-1. Methods: EVOLVE-MS-1 was an open-label, 96-week, phase 3 study assessing DRF safety, tolerability, and efficacy in patients with RRMS. The primary endpoint was safety and tolerability; efficacy endpoints were exploratory. Results: Overall, 75.7% (800/1057) of patients completed the study; median exposure was 1.8 (range: 0.0–2.0) years. AEs occurred in 938 (88.7%) patients, mostly of mild (28.9%) or moderate (50.3%) severity. DRF was discontinued due to AEs in 85 (8.0%) patients, with < 2% discontinuing due to GI or flushing/flushing-related AEs. At Week 96, mean number of gadolinium-enhancing lesions was significantly reduced from baseline (72.7%; p < 0.0001); adjusted annualized relapse rate was 0.13 (95% confidence interval: 0.11–0.15). Conclusion: DRF was generally well tolerated over 2 years, with few discontinuations due to AEs; radiological measures indicated decreased disease activity from baseline. These outcomes support DRF as a treatment option in patients with RRMS.
Comparing the suitability of virtual versus in-person care: Perceptions from pediatricians
Authors: Leong Russell , Sanderson Kate E , Klassen Anne F , Ratcliffe Elyanne M , Zuniga-Villanueva Gregorio 
Published: October 2023

Objectives The COVID-19 pandemic compelled a portion of healthcare to be delivered virtually. As the pandemic waned, health systems strived to find a balance between re-incorporating in-person care while maintaining virtual care. To find when virtual or in-person encounters are more appropriate, we surveyed pediatricians’ perceptions when comparing the suitability of virtual care to in-person care. Methods We surveyed a Canadian tertiary-level pediatric hospital where pediatricians assessed whether specific clinical encounters or tasks were more or less effective virtually than when performed in person. Pediatricians also rated the importance of clinical and patient factors when deciding if a patient needs to be seen in person. Results Of 160 pediatrics faculty members, 56 (35%) responded to the survey. When assessing different types of clinical encounters, triage, multidisciplinary meetings, discharge, and follow ups were more likely to favor virtual encounters. However, first consultations and family meetings were more likely to favor in-person encounters. Regarding clinical tasks, pediatricians were more likely to endorse explaining test results, offering treatment recommendations, and obtaining patient histories virtually. On the contrary, there was a preference for physical examinations, assessing patients visually, and assessing developmental milestones to be performed in person. When deciding if a patient should be seen in person versus virtual, pediatricians rated the patient's condition and communication barriers as the most important factors favoring an in-person appointment. Discussion These results offer an initial framework for pediatricians when choosing which encounter type may be most appropriate for their patients between virtual or in-person appointments.
Vertical and sagittal changes produced by an expander with differential opening versus a fan-type expander: A post-hoc analysis of a randomised controlled trial
Authors: Teixeira Rodrigo , Massaro Camila , Garib Daniela 
Published: October 2023

Objective: To compare the sagittal and vertical cephalometric effects in participants treated with an expander with differential opening (EDO) versus the fan-type expander (FE). Design: Two-arm parallel randomised clinical trial (RCT). Methods: This study comprised cone-beam computed tomography-derived cephalometric images from 48 participants from a RCT. The sample was randomly allocated into two groups. The study was single-blinded. In total, 24 participants were treated with rapid maxillary expansion (RME) using EDO and 24 participants underwent RME using FE. The primary outcomes were the dentoskeletal vertical changes produced by RME. The secondary outcomes were the dentoskeletal sagittal changes. A cephalometric analysis was performed before treatment and 1 or 6 months after the active phase of RME using Dolphin Imaging Software. Intergroup comparisons of interphase changes were performed using the t-test and Mann–Whitney U test ( P < 0.05). Results: The final sample comprised 24 patients (11 men, 13 women; mean age = 7.6 ± 0.9 years) in the EDO group and 24 patients (10 boys, 14 girls; mean age = 7.8 ± 0.9 years) in the FE group. Both expanders produced a similar clockwise rotation of the mandible (FMA; mean difference [MD] = 0.09°, 95% confidence interval [CI] = −1.01 to 0.84). In the FE group, a greater increase of the SNA angle was observed after expansion compared to the EDO group (MD = 1.04°, 95% CI = −1.90 to −1.58). More palatal torque of maxillary incisors was observed in the FE group (MD = 1.32°, 95% CI = 0.05–2.56). Of the participants, 54% reported a little discomfort during the active phase of treatment and 46% of the participants did not report any discomfort. Conclusion: Both expanders produced similar vertical cephalometric changes. FEs caused slightly more maxillary anterior displacement after expansion with a compensatory palatal torque of the maxillary incisors, compared to the EDOs. However, the amount of sagittal difference was not clinically relevant. Trial registration: The trial was registered at ClinicalTrials.gov, under the identifier NCT03705871.
Incidence of Distal Radial Artery Occlusion and its Influencing Factors After Cardiovascular Intervention Via the Distal Transradial Access
Authors: Chen Tao , Li Lamei , Yang Anni , Huang Hui , Shi Ganwei , Li Feng , Li Wenhua , Lu Wei , Xu Lingxia , Li Li , Cai Gaojun 
Published: October 2023

Introduction: One of the important advantages of the distal transradial access (dTRA) is the significant reduction in the incidence of radial artery occlusion (RAO). There are few reports on the influencing factors for distal radial artery occlusion (dRAO) after cardiovascular interventions via the dTRA. Methods: This retrospective analysis included the clinical data of patients who underwent a cardiovascular intervention via the dTRA. The dRAO was evaluated by ultrasound within 24 hours after the procedure. Multivariate logistic analysis was used to explore the influencing factors for dRAO. Results: The incidence of dRAO was 3.5% (28/805) at 24 hours follow-up after the procedure. In the comparison between the 2 groups, the preoperative distal radial artery (DRA) internal diameter in the dRAO group was significantly smaller than that in the non-dRAO group (p=0.001). The prevalence of DRA inner diameter/sheath outer diameter <1 was significantly higher in the dRAO group than in the non-dRAO group (p=0.013). The number of puncture attempts was significantly greater in the dRAO group than in the non-dRAO group (p=0.007). Multivariate logistic analysis showed that DRA inner diameter/sheath outer diameter <1 was an independent risk factor for dRAO (OR=4.827, 95% CI=1.087–21.441, p=0.039). Conclusions: The incidence of dRAO 24 hours after cardiovascular intervention via the dTRA was 3.5%, and a DRA inner diameter/sheath outer diameter <1 was an independent risk factor for dRAO. Preoperative ultrasound assessment of vessel inner diameter and selection of a sheath with a smaller outer diameter may reduce the risk of dRAO. Clinical Impact The incidence of distal radial artery occlusion after cardiovascular intervention was 3.5%. The distal radial artery inner diameter/sheath outer diameter <1 was an independent risk factor for distal radial artery occlusion. Preoperative ultrasound assessment of vessel inner diameter and selection of a sheath with a smaller outer diameter may reduce the risk of distal radial artery occlusion. The number of puncture attempts and compression time were not related to distal radial artery occlusion.