bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of digital health access and use among US adults: A latent class analysis.
Authors: Hegeman Phillip , Vader Daniel , Kamke Kristyn , El-Toukhy Sherine 
Published: January 2024

Abstract

Background
Digital technologies allow users to engage in health-related behaviors associated with positive outcomes. We aimed to identify classes of US adults with distinct digital technologies access and health use patterns and characterize class composition. Data came from Health Information National Trends Survey Wave 5 Cycles 1–4, a nationally representative cross-sectional survey of US adults (N = 13,993). We used latent class analysis to identify digital technologies access and health use patterns based on 32 behaviors and access to requisite technologies and platforms that include the internet, internet-enabled devices, health monitors, and electronic health records (EHRs). We ran a multinomial logistic regression to identify sociodemographic and health correlates of class membership (n = 10,734).
Results
Ten classes captured patterns of digital technology access and health use among US adults. This included a digitally isolated, a mobile-dependent, and a super user class, which made up 8.9%, 7.8%, and 13.6% of US adults, respectively, and captured access patterns from only basic cellphones and health monitors to near complete access to web-, mobile-, and EHR-based platforms. Half of US adults belonged to classes that lacked access to EHRs and relied on alternative web-based tools typical of patient portals. The proportion of class members who used digital technologies for health purposes varied from small to large. Older and less educated adults had lower odds of belonging to classes characterized by access or engagement in health behaviors. Hispanic and Asian adults had higher odds of belonging to the mobile-dependent class. Individuals without a regular healthcare provider and those who had not visited a provider in the past year were more likely to belong to classes with limited digital technologies access or health use.
Discussion
Only one third of US adults belonged to classes that had near complete access to digital technologies and whose members engaged in almost all health behaviors examined. Sex, age, and education were associated with membership in classes that lacked access to 1 + digital technologies or exhibited none to limited health uses of such technologies. Results can guide efforts to improve access and health use of digital technologies to maximize associated health benefits and minimize disparities.
Comparison of Methods To Aggregate Climate Data To Predict Crop Yield: An Application to Soybean
Authors: Chen Mathilde , Guilpart Nicolas , Makowski David 
Published: January 2024

Abstract

High-dimensional climate data collected on a daily, monthly or seasonal time step are now commonly used to predict crop yields worldwide with standard statistical models or machine learning models. Since the use of all available individual climate variables generally leads to calculation problems, over-fitting, and over-parameterization, it is necessary to aggregate the climate data used as predictors. However, there is no consensus on the best way to perform this task, and little is known about the impacts of the type of aggregation method used and of the temporal resolution of weather data on model performances. Based on historical data from 1981 to 2016 of soybean yield and climate on 3,447 sites worldwide, this study compares different temporal resolutions (daily, monthly, or seasonal) and dimension reduction techniques (principal component analysis, partial least square regression, and their functional counterparts) to aggregate climate data used as inputs of machine learning and linear regression models predicting yields. Results showed that random forest models outperformed and were less sensitive to climate aggregation methods than linear regressions when predicting soybean yields. With our models, the use of daily climate data did not improve predictive performance compared to monthly data. Models based on principal component analysis or averages of monthly data showed better predictive performance compared to those relying on more sophisticated dimension reduction techniques. By highlighting the high sensitivity of projected impact of climate on crop yields to the temporal resolution and aggregation of climate input data, this study reveals that model performances can be improved by choosing the most appropriate time resolution and aggregation techniques. Practical recommendations are formulated in this article based on our results.
In vitro and in silico anticoccidial activity of the seeds of Lepidium sativum red and black varieties
Authors: Alebachew Yonatan , Wondu  ,   Tigist Getachew3, Tilahun Debora , Adamu Meskerem , Gebre-Mariam Tsige 
Published: January 2024

Abstract

Coccidiosis is a parasitic disease of major economic importance in the poultry industry. The exploration of natural alternative strategies such as phytochemicals is becoming significant in controlling coccidiosis. Therefore, in the present study, we investigate the in vitro anticoccidial activity of the seeds of red and black Lepidium sativum varieties that have multiple traditional medicinal uses and identify their major active components. The seeds of red and black L. sativum varieties were extracted with 80% methanol and tested for their in vitro anticoccidial activity using a sporulation inhibition assay. The 80% methanol extract of the red variety was solvent partitioned into four fractions, and each was tested for activity. Then, column chromatography of the active fractions was carried out to isolate compounds. The chemical structures of the compounds were determined by spectroscopic methods (1H, 13C and DEPT NMR). The 80 methanol extract of both the black and red varieties inhibited sporulation of oocysts by 83.71% and 98.27% at concentrations of 1000 mg/ml, respectively. Among all tested substances, the chloroform fraction, followed by the hexane, was found to be the most active one with sporulation inhibition values of 93.5% and 98.91% at 500 and 1000 mg/ml doses, respectively. Moreover, linoleic acid, alpha-linolenic acid and methyl sinapate were identified and characterized as the major components of the active fractions. Furthermore, molecular docking and conformational similarity scanning study of the compounds and anticoccidial drugs revealed that methyl sinapate had a strong binding affinity and conformational alignment to dihydrofolate reductase (HYDE score, -41.6 KJ/mol) and trimethoprim (FlexS scores, 0.84), respectively. In addition, to find further chemically similar analogs of methyl sinapate, we navigated the chemical space library of billions of commercially available synthetic compounds using the bioinformatics tool infiniSee 5.0.1 and identified 100 molecules with FlexS scores in the range of 0.67–0.78. These findings along with the safety profile derived from the acute oral toxicity tests of the extract suggest L. sativum as an alternative source of treatment for coccidiosis.
Multiphenotypic sinonasal carcinoma with adenoid cystic features: reporting a rare case.
Authors: Zou xi 
Published: January 2024

Abstract
Multiphenotypic sinonasal carcinoma with adenoid cystic features (MSCAC) is an uncommon and aggressive malignancy that primarily affects the sinonasal tract. It is characterized by a varied histological appearance, exhibiting similarities to both adenoid cystic carcinoma (ACC) and other sinonasal malignancies. MSCAC presents a diagnostic challenge due to its histological features that overlap with other tumors, emphasizing the importance of accurate diagnosis for appropriate management and prognosis. Here, we present the case of a 49-year-old male with no notable medical history, who presented to the Emergency department with nasal bleeding. A biopsy revealed a tumor displaying a prominent basaloid component, accompanied by high mitotic activity and necrosis, an adenoid cystic-like component, and a non-keratinizing squamous cell component. Immunohistochemistry was performed and supported the diagnosis of multiphenotypic sinonasal carcinoma with adenoid cystic features. In conclusion, MSCAC is a rare and aggressive malignancy of the sinonasal tract. Its diverse histological appearance and overlapping features with other tumors present diagnostic challenges. This abstract provides an overview of MSCAC, highlighting its clinical presentation, histopathological characteristics, diagnostic challenges, and treatment options. Further research and collaboration among experts are necessary to enhance our understanding of this uncommon malignancy and develop standardized diagnostic and therapeutic approaches.
Specific Impact of Digital Transformation in Economy on Bank Strategy Administration
Authors: Anisimov A. Yu. , Plakhotnikova M. A. , Suslova M. A. , Skryabin O. O. 
Published: January 2024

Strategy administration is an essential link in the outline of credit organization management, its optimality impacts the efficiency of bank functioning on target markets in general and its competitiveness in particular. Economy digitalization acts as an external macro-factor in respect of the bank and its management system and the influence of this factor is quite strong. These circumstances cause the necessity to adapt strategies of the bank development to new conditions. The goal of the research is to assess macro-environment of the Russian bank sector. The following methods were used in the research: comparative analysis, statistic analysis, benchmarking, classification and ranging and PEST-analysis. The research identified stages of strategic transformation of the banking system under the influence of digitalization and showed the impact of digital transformation in economy on bank strategy administration. The authors came to the conclusion that innovation strategy included in corporate strategy of the bank assumes a high degree of using advanced information technologies, detailed monitoring of market of digital solutions for the bank and maximum automation of banking business processes.
Magnetic Nanomaterials for Sample Preparation of Disease-related
Biomarkers
Authors: Hamidi Samin , Siahi-Shadbad Mohammadreza , Taghvimi Arezou , Kurbanoglu Sevinc 
Published: January 2024

Abstract:
Measuring clinically relevant biomarkers is critical for disease screening, diagnosis,
and therapeutic monitoring. However, analyzing trace biomarkers in complex biological fluids
remains challenging. Magnetic solid phase extraction (MSPE) has recently emerged as a promising sample preparation approach due to its simplicity, efficiency, and ability to selectively isolate
biomarkers. Databases, including PubMed, Web of Science, and Scopus, were systematically
searched for studies on MSPE for clinical biomarkers. Key findings on nanomaterial synthesis
strategies, surface modifications, and applications in biomarker isolation were synthesized. Recent research demonstrates magnetic nanoparticles with tailored surface chemistry can selectively extract biomarkers like cancer antigens, neurotransmitters, and pharmaceuticals from matrices
such as plasma, urine, and serum. MSPE enables clinically relevant limits of detection, high recovery, and purification in a rapid and simple workflow. This technique shows significant potential to improve clinical diagnostics. Further research on novel magnetic materials and surface
functionalization is warranted. This review provides insights for researchers aiming to develop
MSPE methods for sensitive and selective analysis of clinical biomarkers.
Application of Carbon-based Nano Adsorbents in the Extraction of
Amphetamines from Urine Samples
Authors: Taghvimi Arezou , Dastmalchi Siavoush , Hamidi Samin , Kurbanoglu Sevinc , Khoshkbar Sadigh Anis , Javadzadeh Yousef 
Published: January 2024

Abstract:
Amphetamines, as psychoactive drugs, are extensively abused in society and cause
serious mental and physical disorders among young people. Furthermore, the extremely euphoric
and excited sense of stimulant consumption leads to dramatic social problems. Determination of
various analytes and related metabolites in the complex biological matrices at trace levels has
made sample preparation an indispensable part of forensic sciences. According to the problems
above, providing high sensitivity, solving some analytical problems like matrix effects in LCMS-MS, and needing a cleaner extract are remarkable aspects of novel sample preparation methods in drug analysis. Application of nanotechnology and carbon-based nanocomposites seems to
bring the above properties in developed and novel sample preparation methods. This review will
try to provide an overview of different carbonic nano adsorbents used in sample preparation
methods of amphetamines and discuss their superiority over the other nanomaterials.
A Comprehensive Review on Polyphenols based Nanovesicular System for Topical Delivery
Authors: Singh Anshu , Fatima Zeeshan , Srivastava Dipti 
Published: January 2024

Background:
Polyphenols are naturally occurring compounds having more than one hydroxy
functional group. They are ubiquitous secondary plant metabolites possessing a wide range of
pharmacological activity. Brightly colored fruits and vegetables are the natural source of polyphenols.
Majorly, they possess antioxidant, anti-inflammatory and antimicrobial properties which make them
suitable candidates to target skin related disorders.

Objective:
This study is focused to explore the potential of polyphenols loaded nanovesicles for skin
related disorders. The aim of the study is to review the applicability and efficacy of different vesicular
systems encapsulated with various classes of polyphenols for skin related disorders, thus opening the
opportunity for future studies based on these drug delivery systems.

Methods:
Web of Science, PubMed, Scopus database, and the search engine Google Scholar were
accessed for the literature search. The results were then filtered based on the titles, abstracts, and
accessibility of the complete texts.

Results:
The expository evaluation of the literature revealed that various nanovesicles like liposomes,
niosomes, ethosomes and transferosomes incorporating polyphenol have been formulated to address
issues pertaining to delivery across the skin. These developed nano vesicular systems have shown
improvement in the physicochemical properties and pharmacological action.

Conclusion:
Polyphenol based nano-vesicular formulations have proved to be an effective system for
topical delivery and henceforth, they might curtail the use of other skin therapies having limited applicability.
Bone Metabolism in Men who Live with HIV Aged 50 years and Over:
Impact of Infection Duration
Authors: Caglar Bilge , Durcan Emre , Karaali Ridvan , Balkan Ilker Inanc , Kaya Sibel Yildiz , Yavuzer Hakan , Konukoglu Dildar , Aygun Gokhan , Saltoglu Nese , Bulut Iclal Nur , Sonmezoglu Kerim , Kadioglu Pinar , Mete Bilgul , Tabak Omer Fehmi 
Published: January 2024

Background:
Early diagnosis and effective antiretroviral therapy (ART) lead to similar
life expectancy in people living with HIV (PLWH) compared to the general population. This population
faces problems such as decreased bone mineral density (BMD) and increased fracture risk.
The aim of this study was to determine the prevalence of osteoporosis in men aged 50 years and
over who were PLWH and to determine risk factors and changes in bone metabolism with bone
turnover markers.

Methods:
79 male PLWH aged 50 years and over were followed up in our outpatient clinic between
May 2021 and October 2021. The patients’ demographic, clinical, laboratory, and DEXA
data were analyzed. Serum levels of bone turnover markers were measured.

Results:
The prevalence of osteopenia, osteoporosis, and normal BMD was found to be 55.7%,
13.9%, and 30.4%, respectively. A correlation was found between low BMD and low body mass
index, elapsed time since diagnosis of HIV infection, high rate of use of ART, and long usage
time of tenofovir disoproxil fumarate + protease inhibitor. A one-year increase in HIV infection
duration was associated with an increased risk of low BMD by 1.246.

Conclusion:
Compared to studies conducted on the general population, the prevalence of osteoporosis
in male PLWH aged 50 years and older was two times higher. The limited effect of the duration
of ART use on low BMD may be due to the patients' histories of replacement therapy.
Therefore, to eliminate the negative effects of ART on BMD, it may be beneficial to start replacement
therapy when necessary.
Finerenone: A Novel Drug Discovery for the Treatment of Chronic Kidney
Disease
Authors: Rana Akshita , Sahu Jagdish K. 
Published: January 2024

Background:
The most common cause of chronic kidney disease (CKD) is diabetic
nephropathy (DN). Primarily mineralocorticoid receptor antagonists (MRAs) (spironolactone and eplerenone),
angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were used for
the treatment of CKD, but due to the high risk of hyperkalaemia, the combination was infrequently
used. Currently after approval by FDA in 2021, finerenone was found to be effective in the treatment
of CKD. Finerenone slowdowns the progression of diabetic nephropathy and lessens the cardiovascular
morbidity in DN patients.

Objective:
The main objective of this review article is to provide a comprehensive and insightful
overview of the role of finerenone by mainly focusing on its pharmacological properties, toxicity,
uses, bioanalytical technique used for determination, and treatment options.

Materials and Method:
Finerenone works by inhibiting the action of the mineralocorticoid receptor.
Finerenone is quickly absorbed from the digestive tract after oral treatment and achieves peak plasma
concentrations in 1-2 hours.

Result:
Finerenone is actively metabolized through oxidation, epoxidation substitution, and direct
hydroxylation. Elimination of finerenone is done through urine and feces. Determination of finerenone
can be done through HPLC-MS and LSC.

Conclusion:
The present review covers the complete picture of ADME properties, bioanalytical techniques,
clinical trials, toxicity, and possible avenues in this arena. Finerenone is effective compared
to other mineralocorticoid receptor-like spironolactone and eplerenone, for the treatment of chronic
kidney disease.
The Role of Triglycerides in Atherosclerosis: Recent Pathophysiologic
Insights and Therapeutic Implications
Authors: Akivis Yonatan , Alkaissi Hussam , McFarlane Samy I. , Bukharovich Inna 
Published: January 2024

Abstract:
Triglycerides have long been recognized as a cardiovascular disease risk factor. However,
their precise role in atherosclerosis and potential utility as a therapeutic target remains debated
topics. This review aims to shed light on these aspects by exploring the complex relationship
between triglycerides and atherosclerosis from pathophysiological and pharmacological
perspectives.

:
Triglycerides, primarily carried by chylomicrons and very low-density lipoproteins, play an essential
role in energy storage and utilization. Dysregulation of triglyceride homeostasis and triglyceride-
rich lipoproteins metabolism often leads to hypertriglyceridemia and subsequently increases
atherosclerosis risk. Triglyceride-rich lipoproteins remnants interact with arterial wall
endothelial cells, get retained in the subendothelial space, and elicit inflammatory responses,
thereby accelerating atherogenesis.

:
Despite the clear association between high triglyceride levels and increased cardiovascular disease
risk, intervention trials targeting triglyceride reduction have produced mixed results. We
discuss a range of triglyceride-lowering agents, from fibrates to omega-3 fatty acids, with a focus
on their mechanism of action, efficacy, and major clinical trial outcomes. Notably, the role
of newer agents, such as angiopoietin-like protein 3 and apolipoprotein C3 inhibitors, is also explored.

:
We highlight the challenges and controversies, including the ongoing debate on the causal role
of triglyceride in atherosclerosis and the discordant outcomes of recent clinical trials. The potential
confounding effects of associated risk factors, such as elevated apolipoprotein B, insulin resistance,
and metabolic syndrome, are considered.

:
In conclusion, this review underscores the importance of a nuanced approach to understanding
the role of triglycerides in atherosclerosis and their potential as a therapeutic target. Further research
is needed to unravel the complex interplay between triglycerides, triglyceride-rich lipoproteins,
and associated factors in atherosclerosis pathogenesis and refine triglyceride-targeted
therapeutic strategies.
Synthesis, Characterization, and Investigation of Doxorubicin Drug
Release Properties of Poly(acrylamide-co-acrylic Acid/Maleic
Acid)-Hydroxyapatite Composite Hydrogel
Authors: Akkaya Birnur , Akkaya Recep 
Published: January 2024

Background:
Hydroxyapatite and its derivatives have been used for a lot of applications.
One of them is drug release studies. Due to its low adhesion strength and lack of the strength and
durability required for load-carrying applications, there is a need to improve the properties of hydroxyapatite.
For this aim, the most important factors are increasing pH sensitivity and preventing
coagulation. Mixing it with multifunctional polymers is the best solution.

Objectives:
The main objectives are: 1- preparing poly(acrylamide-co-acrylic acid/maleic acid)-
hydroxyapatite (PAm-co-PAA/PMA–HApt), 2- assessment of (PAm-co-PAA/PMA–HApt) and
dox-loaded poly(acrylamide-co-acrylic acid/maleic acid) (Dox-(PAm-co-PAA/PMA–HApt)) composite
hydrogels, and 3- elucidating the difference in behavior of drug release studies between hydroxyapatite
(HApt) and poly(acrylamide-co-acrylic acid/maleic acid) composite hydrogels.

Methods:
A composite of PAm-co-PAA/PMA–HApt was prepared by direct polymerization of
acrylamide-co-acrylic acid/maleic acid in a suspension of HApt. The drug loading and release features
of PAm-co-PAA/PMA–HApt and HApt were then investigated for doxorubicin (dox) release.
Using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron
microscopy (SEM), and thermogravimetric analysis (TG/DTA), this unique composite hydrogel has
been physicochemically investigated. Also, a colorimetric assay was used to assess the in vitro
biocompatible support and anticancer activity of HApt and the newly developed composite hydrogel
XTT (2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide) assay.

Results:
According to the results of drug release studies of this new material, it is pH sensitive, and
PAm-co-PAA/PMA–HApt demonstrated a faster release than HApt at 37°C in the acidic solution
of pH 4.5 than in the neutral solution of pH 7.4. The XTT assay outcomes also demonstrated the
biocompatibility of PAm-co-PAA/PMA–HApt and HApt and the cytotoxic effect of dox-loaded
PAm-co-PAA/PMA–HApt.

Conclusion:
It should be inferred that the drug release profile was improved at pH 4.5 by the newly
produced pH-sensitive composite hydrogel.