bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutrophil degranulation, endothelial and metabolic dysfunction in unvaccinated long COVID patients
Authors: Di Ciaula Agostino , Liberale Luca , Portincasa Piero , Khalil Mohamad , Galerati Ilaria , Farella Ilaria , Noto Antonino , JohnBritto Stephy , Moriero Margherita , Michelauz Cristina , Frè Federica , Olivero Chiara , Bertolotto Maria , Montecucco Fabrizio , Carbone Federico , Bonfrate Leonilde 
Published: January 2024

AbstractBackgroundLong COVID symptoms are widely diffused and have a poorly understood pathophysiology, with possible involvement of inflammatory cytokines.Materials and MethodsA prospective follow‐up study involved 385 unvaccinated patients, started 1 month after SARS‐CoV‐2 infection and continued for up to 12 months. We compared circulating biomarkers of neutrophil degranulation, endothelial and metabolic dysfunction in subjects with long COVID symptoms and in asymptomatic post‐COVID controls.ResultsThe highest occurrence of symptoms (71%) was after 3 months from the infection, decreasing to 62.3% and 29.4% at 6 and 12 months, respectively. Compared to controls, long COVID patients had increased levels of the neutrophilic degranulation indices MMP‐8 and MPO, of endothelial dysfunction indices L‐selectin and P‐selectin. Among indices of metabolic dysfunction, leptin levels were higher in long COVID patients than in controls.ConclusionIn unvaccinated patients, symptoms may persist up to 1 year after acute COVID infection, with increased indices of neutrophil degranulation, endothelial and metabolic dysfunction. The clinical implications of specific inflammatory biomarkers require further attention, especially in individuals with fatigue and long COVID‐linked cognitive dysfunctions.
Broadband and rural development: Impacts of the U.S. Department of Agriculture Broadband Initiatives Program on saving and creating jobs
Authors: Rupasingha Anil , Pender John , Williams Ryan 
Published: January 2024

AbstractThis study analyzed the impact of the USDA's Broadband Initiatives Program on employment and business survival. While average employment declined in both program and non‐program areas, the decline was less severe in program areas, suggesting a positive impact. This impact was primarily observed in metro counties, the service sector, and employer establishments. Businesses in program areas were also less likely to fail than those outside the program areas, with variation across location, business type, and industry.
Extracellular vesicles from keratinocytes and other skin‐related cells in psoriasis: A review
Authors: Qi Fei , Jin Hongzhong 
Published: January 2024

AbstractPsoriasis is a highly prevalent chronic inflammatory skin condition involving abnormal proliferation and differentiation of keratinocytes, together with substantial infiltration of immune cells. Extracellular vesicles (EVs), which are released spontaneously into the extracellular space by virtually all cell types, play a crucial role in cell‐to‐cell communication by delivering bioactive cargos such as mRNA nucleic acids and proteins to recipient cells. Numerous studies have highlighted the significant contributions of EVs to both the pathogenesis and treatment of psoriasis. This review provides a concise overview of skin‐derived EVs and their involvement in the pathogenesis of psoriasis.
Effects of operating room nursing intervention on wound infection in patients undergoing ovarian cysts surgery: A meta‐analysis
Authors: Lin Jian‐Hua , Huang Wen , Zhu Ying‐Ju , Duan Hong‐Wei 
Published: January 2024

AbstractWe conducted this study aimed to explore the effect of operating room nursing intervention on wound infection in patients undergoing ovarian cysts surgery. A computer system was used to search PubMed, Web of Science, EMBASE, Cochrane Library, Wanfang, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure databases, from database inception to October 2023, for randomised controlled trials (RCTs) on the application of operating room nursing intervention to ovarian cyst surgery. Literature that met the requirements was independently screened by two researchers, and data were extracted and assessed for literature quality. RevMan 5.4 software was applied for data analysis. Fifteen RCTs involving 1187 patients were finally included. The analyses revealed that, compared with routine nursing, the implementation of operating room nursing intervention had a significant advantage in reducing the incidence of wound infections (1.17% vs. 5.44%, odds ratio [OR]: 0.30, 95% confidence interval [CI]: 0.15–0.58, p = 0.0004) and postoperative complications (6.34% vs. 25.17%, OR: 0.20, 95%CI: 0.13–0.29, p < 0.00001), as well as being able to shorten the operative time (standardised mean difference [SMD]: ‐3.93, 95%CI: −5.67 to −2.20, p < 0.00001), hospital length of stay (SMD: −2.54, 95%CI: −3.19 to −1.89, p < 0.00001) and gastrointestinal recovery time (SMD: −1.61, 95%CI: −2.24 to −0.98, p < 0.00001) in patients undergoing ovarian cysts surgery. This study confirmed by meta‐analysis that the operating room nursing intervention can significantly reduce the incidence of wound infection and complications, shorten the operative time, gastrointestinal recovery time, and hospital length of stay after ovarian cyst surgery.
Use of consecutive transcutaneous oxygen measurement when assessing the need for revascularization and association with the outcomes of ischemic diabetic ulcers
Authors: Sun Hao‐Yi , Wu Yi‐Chun , Sung Li‐Chin , Lin Xin‐Yi , Tsai Feng‐Chou , Lin Yen‐Kuang , Tam Ka‐Wai , Wang Fu‐Yu , Chang Shun‐Cheng 
Published: January 2024

AbstractThis study compared the ankle‐brachial index (ABI) with transcutaneous oxygen pressure (TcPO2) in assessing peripheral vascular disease (PVD) prevalence in 100 diabetic foot ulcer (DFU) patients. Patients were categorized into vascular or nonvascular reconstruction groups and underwent both ABI and TcPO2 measurements four times over 6 months. Predictive validity for PVD diagnosis was analysed using the area under the receiver‐operating characteristic curve (AUC). The study found TcPO2 to be a superior predictor of PVD than ABI. Among the DFU patients, 51 with abnormal TcPO2 values underwent vascular reconstruction. Only TcPO2 values showed significant pretreatment differences between the groups and increased post‐reconstruction. These values declined over a 6‐month follow‐up, whereas ABI values rose. For those with end‐stage renal disease (ESRD), TcPO2 values saw a sharp decrease within 3 months. Pre‐reconstruction TcPO2 was notably lower in amputation patients versus limb salvage surgery patients. In conclusion, TcPO2 is more effective than ABI for evaluating ischemic limb perfusion and revascularization necessity. It should be prioritized as the primary follow‐up tool, especially for ESRD patients.
Evaluating the efficacy of recombinant human growth factors in scar remodelling for patients with facial soft tissue injuries
Authors: Zhang Baiyu , He Zonghai , Zhao Hui , Gao Hongbin , Zhang Zhiying , Gao Zhenhua , Ke Kunbin 
Published: January 2024

AbstractFacial soft tissue injuries, often resulting in scarring, pose a challenge in reconstructive and aesthetic surgery due to the need for functional and aesthetic restoration. This study evaluates the efficacy of recombinant human growth factors (rhGFs) in scar remodelling for such injuries. A retrospective evaluation was conducted from January 2020 to January 2023, involving 100 patients with facial soft tissue injuries. Participants were divided equally into a control group, receiving standard cosmetic surgical repair, and an observation group, treated with rhGFs supplemented cosmetic surgery. The study assessed scar characteristics (pigmentation, pliability, vascularity, height), hospital stay duration, tissue healing time, complication rates and patient satisfaction. The observation group demonstrated significant improvements in all scar characteristics, with notably better pigmentation, pliability, vascularity and height compared with the control group. The rhGF treatment also resulted in reduced hospital stay duration and faster tissue healing. Notably, the total complication rate was significantly lower in the observation group (10%) compared with the control group (34%). Additionally, patient satisfaction levels were higher in the observation group, with 98% combined satisfaction compared with 76% in the control group. The application of rhGFs in treating facial soft tissue injuries significantly enhances scar remodelling, expedites healing, reduces complications and improves patient satisfaction. These findings establish rhGFs as a valuable tool in the management of facial soft tissue injuries, highlighting their potential in improving both functional and aesthetic outcomes.
The use of predator tags to explain reversal movement patterns in Atlantic salmon smolts (Salmo salar L.)
Authors: Waters C. , Cotter D. , O'Neill R. , Drumm A. , Cooney J. , Bond N. , Rogan G. , Maoiléidigh N. Ó' 
Published: January 2024

AbstractAcoustic telemetry has seen a rapid increase in utility and sophistication in recent years and is now used extensively to assess the behavior and survival rates of many aquatic animals, including the Atlantic salmon. As part of the salmon's complex life cycle, salmon smolts are thought to make a unidirectional migration from fresh water to the sea, which is initiated by changes in their physiology. However, some tag movement patterns do not conform with this and can be difficult to explain, particularly if the tagged fish has been eaten by a predator. This study combines the use of predator tags with machine learning techniques to understand the fate of migrating salmon smolts and thereby improve estimates for migration success. Over 3 years between 2020 and 2022, 217 salmon smolts (including wild and hatchery‐reared ranched fish) were acoustically tagged and released into an embayment on the west coast of Ireland. Some tagged smolts were observed to return from the estuary back into a saline lagoon through which they had already migrated. To distinguish between the movement of a salmon smolt and that of a predator, predator tags were deployed in migrating smolts in 2021 and 2022. The addition of a temperature sensor in 2022 enabled the determination of predator type causing the returning movement. A significant number of predator tags were triggered, and the patterns of movement associated with these triggered tags were then used with two types of machine learning algorithms (hierarchical cluster analysis and random forest) to identify and validate the behavior of smolts tagged without extra sensors. Both models produced the same outputs, grouping smolts tagged with predator tags with smolts tagged without the additional sensors but showing similar movements. A mammalian predator was identified as the cause of most reversal movement, and hatchery‐reared ranched smolts were found to be more likely predated upon by this predator than wild smolts within the lake and the estuary. However, overall migration success estimates were similar for both wild and hatchery‐reared ranched fish. This study highlights the value of predator tags as an essential tool in the overall validation of detection data.
A comprehensive review of the medical and cosmetic applications of exosomes in dermatology
Authors: Yousefian Faraz , Espinoza Liliana , Yadlapati Sujitha , Lorenc Z. Paul , Gold Michael 
Published: January 2024

AbstractBackgroundExosomes are a subset of extracellular vesicles that are released by all cell types and are theorized to play a crucial role in intercellular communication. Ranging from 40 to 160 nm in diameter, exosomes contain a variety of genetic materials including DNA, RNA, mRNA, metabolites, proteins, and lipids depending on their cellular origin.AimGiven that intercellular communication is abetted by the exchange of cellular components via exosomes, their applied use can have important implications for disease pathology and exosome‐based therapeutics. We provide a comprehensive review of the current application of exosomes in medical (and skin) diseases and in cutaneous medical aesthetics.MethodsA literature search was conducted on PubMed reviewing exosomes and their application in medical and aesthetic fields.ResultsWhile the therapeutic use of exosomes in the treatment of medical and cosmetic dermatological procedures is promising, it is also important to note that most studies implementing exosomes as therapeutic agents have been conducted in preclinical models, thus highlighting the need for additional studies and clinical trials. One more important note in the aesthetic world associated with exosomes is that in the United States, at the time of this writing, exosomes may only be topically applied and not injected into the skin, as is done in many countries worldwide.ConclusionThere is a need for additional studies and clinical trials to evaluate the safety and therapeutic effect and safety of exosomes in medical and aesthetic fields.
Coping profiles and their association with vicarious post‐traumatic growth among nurses during the three waves of the COVID‐19 pandemic
Authors: Kalaitzaki Argyroula , Theodoratou Maria , Tsouvelas George , Tamiolaki Alexandra , Konstantakopoulos George 
Published: January 2024

AbstractAimsThis study aimed to examine (a) changes in coping strategies and vicarious post‐traumatic growth (VPTG) across three timepoints of the COVID‐19 pandemic among nurses; (b) discrete groups of nurses with unique coping profiles and (c) the association of these coping profiles with VPTG across the timepoints.BackgroundAlthough literature abounds with the negative mental health consequences of the pandemic among healthcare professionals, much less is known about the positive consequences on nurses, the coping strategies that they use, and how these change over time.DesignThis was a cross‐sectional web‐based survey at three timepoints during the pandemic.MethodsA sample of 429 nurses completed online the Post‐Traumatic Growth Inventory (PTGI) and the Brief Coping Orientation to Problems Experienced Inventory (COPE) to measure vicarious post‐traumatic growth (VPTG) and coping strategies, respectively. The STROBE checklist was used to report the present study.ResultsSignificantly higher VPTG scores were observed during the third timepoint. Different coping strategies were employed across the three timepoints. Nurses responded to the pandemic either with an active, an avoidant or a passive coping profile. Significantly higher VPTG levels were reported by the nurses of the active profile compared to those of the passive profile, whereas the difference between active and avoidant profiles was not significant.ConclusionsNotwithstanding the preponderance of the nurses with the active coping profile in achieving high VPTG, the avoidant copers had more gains (VPTG) than the passive copers, suggesting that doing something to cope with the stressor—let it be trying to avoid it—was better than doing nothing.Relevance to Clinical PracticeThe identification of distinct coping profiles among nurses and their association with VPTG is of particular use to policymakers and practitioners in developing tailored prevention and intervention efforts to help the nurses effectively manage the demands of the pandemic.Patient or Public ContributionNo patient or public contribution since the study was exclusively conducted by the authors.
Norwegian perspectives on health care for people with intellectual and developmental disabilities
Authors: Skorpen Stine , Søndenaa Erik 
Published: January 2024

AbstractThe Norwegian health care system is built on individual rights and the principles of universal access, decentralization, and free choice of provider. Norway has universal health coverage, funded primarily by general taxes and by payroll contributions shared by employers and employees. Local authorities at the municipal level organize and finance primary health care services according to local demand and within national frameworks. Habilitation services are offered both in the primary health care and as a part of the specialist health services. They offer both inpatient and outpatient services for people with intellectual/developmental disabilities (IDD). National guidelines, known as Good health and care services for people with IDD, have recently (2021) been launched after various reports over the years of serious breaches and challenges in the health and care services provided to people with IDD.
Primary school children's conflicted emotions about using their heritage languages in multilingual classroom tasks
Authors: Van Gorp Koen , Verheyen Steven 
Published: January 2024

AbstractFor many children in Flanders, Belgium, the language of instruction is not their first language. Allowing children to use their heritage languages in the classroom has been argued to have functional and socioemotional benefits. In two exploratory studies, we introduced a multilingual task in four classrooms across three linguistically and socially diverse primary schools, where Dutch was the language of instruction, to determine how students experience the opportunity to use their linguistic repertoire in class. The multilingual task was preceded by an assessment of students’ emotional reactions to the languages they speak through the Self‐Assessment Manikin gauging students’ emotional responses (pleasure, arousal, and dominance), and followed by a semistructured interview on students’ language choices. Both studies yielded similar results. Students generally indicated that they felt happy, calm, and in control when speaking their heritage language. Despite these positive assessments, many students refrained from using their heritage language in the multilingual tasks. A qualitative analysis revealed a variety of language‐related reasons leading to linguistic insecurity, language anxiety, and not using the heritage language: perceived language proficiency, language norms, language status, and appropriate contexts for language use. Conversely, we also identified several students who felt proud to showcase their heritage language. While multilingual tasks have the potential to induce positive emotions in students, teachers need to be aware of potential backlash and prepared to navigate the negative emotions surrounding contested language choices.
The association between fear of childbirth and social support through the Internet and Social Networking Services in pregnant women: A cross‐sectional study
Authors: Seto Natsuki , Tahara‐Sasagawa Emi , Yonezawa Kaori , Hikita Naoko , Usui Yuriko , Haruna Megumi 
Published: January 2024

AbstractSocial support is an important factor in reducing fear of childbirth (FOC). Recently, the Internet and Social Networking Services (SNS) have become new forms of social support. However, it is unclear whether such support can reduce pregnant women's fear. This study aimed to investigate the association between FOC and social support through the Internet and SNS in pregnant women. A cross‐sectional study using a web‐based questionnaire including questions about FOC, social support, the Internet and SNS usage, psychological variables, and sociodemographic variables was conducted. Data from 111 participants were analyzed. A greater number of social support from people who are often seen during pregnancy, and becoming relieved by interaction with others through the Internet and SNS were negatively associated with FOC. This study showed that face‐to‐face social support was associated with lower FOC, while social support through the Internet and SNS was not. Further research is needed on how to use Internet and SNS to reduce FOC in pregnant women.
Predictors of physical inactivity among pregnant women
Authors: Xiang Zhixuan , Sun Ke , Han Rongrong , Chen Lu , Wang Zhong , Gao Lingling 
Published: January 2024

AbstractIt is recommended that pregnant women be physically active to promote maternal and child health. This study aimed to explore the prevalence of physical inactivity and its modifiable predictors in the three trimesters in Chinese pregnant women. Four hundred forty‐four pregnant women completed the Pregnant Physical Activity Questionnaire in the first, second, and third trimesters. The prevalence of physical inactivity reached its highest (66.2%) in the first trimester and lowest (19.4%) in the second trimester. Pregnant women with inadequate physical activity knowledge and low self‐efficacy were at higher risk for physical inactivity. Monitoring physical inactivity could be incorporated into antenatal care and start from the first trimester. Prenatal care professionals should take action to increase pregnant women's physical activity self‐efficacy and knowledge to enhance their physical activity.
Dysphagia associated with esophageal wall thickening in patients with nonspecific high‐resolution manometry findings: Understanding motility beyond the Chicago classification version 4.0
Authors: Choi Jin Young , Jung Kee Wook , Pandolfino John E. , Choi Kyungmin , Park Young Soo , Na Hee Kyong , Ahn Ji Yong , Lee Jeong Hoon , Kim Do Hoon , Choi Kee Don , Song Ho June , Lee Gin Hyug , Jung Hwoon‐yong 
Published: January 2024

AbstractBackgroundPrevious studies have demonstrated that 50% of patients with normal high‐resolution manometry (HRM) findings or ineffective esophageal motility (IEM) may have abnormal functional luminal imaging probe (FLIP) results. However, the specific HRM findings associated with abnormal FLIP results are unknown. Herein, we investigated the relationship between nonspecific manometry findings and abnormal FLIP results.MethodsWe retrospectively analyzed 684 patients who underwent HRM at a tertiary care center in Seoul, Korea, based on the Chicago Classification version 4.0 protocol.Key ResultsAmong the 684 patients, 398 had normal HRM findings or IEM. Of these 398 patients, eight showed esophageal wall thickening on endoscopic ultrasonography or computed tomography; however, no abnormalities were seen during esophagogastroduodenoscopy. Among these eight patients, seven showed repetitive simultaneous contractions (RSCs) in at least one of the two positions: 61% (±29%) in 10 swallows in the supine position and 51% (±30%) in five swallows in the upright position. Four patients who underwent FLIP had a significantly decreased esophagogastric junction distensibility index (1.0 ± 0.5 at 60 mL). Two of these patients underwent per‐oral endoscopic myotomy (POEM) due to a lack of response to medication. Esophageal muscle biopsy revealed hypertrophic muscle with marginal eosinophil infiltration.Conclusions & InferencesA subset of patients (2%) with normal HRM findings or IEM and RSCs experienced dysphagia associated with poor distensibility of the thickened esophageal wall. FLIP assessment or combined HRM and impedance protocols may help better define these patients who may respond well to POEM.