bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moderating role of internal factors in corporate social responsibility reporting persistence and corporate market value
Authors: Ellili Nejla Ould Daoud , Kuzey Cemil , Uyar Ali , Karaman Abdullah S. 
Published: January 2024

AbstractThe primary purpose of this study is to explore the internal drivers (i.e., board monitoring, financial slack, and shareholder‐orientedness) of corporate social responsibility (CSR) reporting persistence over the years and to test the value relevance of CSR reporting persistence. We also investigate whether internal factors moderate the relationship between CSR reporting persistence and corporate market value. The study draws on a sample of 52,948 observations between 2002 and 2021, and a country‐industry‐year fixed effect regression was executed. The results indicate that board monitoring, financial slack, and shareholder‐orientedness all predict CSR reporting persistence. We also find that CSR reporting persistence enhances corporate market value, and board monitoring, financial slack, and shareholder‐orientedness positively moderate the relationship between CSR reporting persistence and corporate market value. The findings are largely robust to the instrumental variable probit regression, entropy balancing, propensity score matching, alternative firm value proxy, alternative samples, and pre‐ and post‐European Union Directive 95/2014 periods.
Clinical impact of epithelial–mesenchymal transition for cancer therapy
Authors: Mukerjee Nobendu , Nag Sagnik , Bhattacharya Bikramjit , Alexiou Athanasios , Mirgh Divya , Mukherjee Dattatreya , Adhikari Manab Deb , Anand Krishnan , Muthusamy Raman , Gorai Sukhamoy , Thorat Nanasaheb 
Published: January 2024

AbstractThe epithelial–mesenchymal transition (EMT) represents a pivotal frontier in oncology, playing a central role in the metastatic cascade of cancer—a leading global health challenge. This comprehensive review delves into the complexities of EMT, a process where cancer cells gain exceptional mobility, facilitating their invasion into distant organs and the establishment of secondary malignancies. We thoroughly examine the myriad of factors influencing EMT, encompassing transcription factors, signalling pathways, metabolic alterations, microRNAs, long non‐coding RNAs, epigenetic changes, exosomal interactions and the intricate dynamics of the tumour microenvironment. Particularly, the review emphasises the advanced stages of EMT, crucial for the development of highly aggressive cancer phenotypes. During this phase, cancer cells penetrate the vascular barrier and exploit the bloodstream to propagate life‐threatening metastases through the mesenchymal–epithelial transition. We also explore EMT's significant role in fostering tumour dormancy, senescence, the emergence of cancer stem cells and the formidable challenge of therapeutic resistance. Our review transcends a mere inventory of EMT‐inducing elements; it critically assesses the current state of EMT‐focused clinical trials, revealing both the hurdles and significant breakthroughs. Highlighting the potential of EMT research, we project its transformative impact on the future of cancer therapy. This exploration is aimed at paving the way towards an era of effectively managing this relentless disease, positioning EMT at the forefront of innovative cancer research strategies.
Host–microbiota interaction during cancer progression from bulk to single‐cell level
Authors: Ma Yong‐Jing , Zhu Run‐Ze , Liu Ning‐Ning 
Published: January 2024

AbstractBackgroundCancer, a global threat to human health, refers to a large crowd of lethal diseases that can start in almost all tissues or organs of our body when abnormal cells grow uncontrollably and beyond their usual boundaries, followed by invading adjacent normal tissues and spreading to distant organs. Recently, substantial evidence has demonstrated polymorphic microbiome as an emerging cancer characteristic present in a variety of tumour types. By releasing metabolites or other signalling molecules, microbiota can affect immune cell differentiation and activity, including both innate and adaptive immunological responses, as well as the growth and multiplication of cancer cells. It was now employed as a biomarker to predict the patients’ survival rate and the degree of cancer progression.MainTo investigate the underlying mechanism and the technology development of how polymorphic microbiome influence the tumour microenvironment and subsequently cancer progression, we have carried out systematic literature review about polymorphic microbiome and tumour development from bulk to single‐cell level.ConclusionsHere, we provide an overview of the current advancements of host–microbiota interactions during cancer progression from bulk to single‐cell level and discuss the challenges and opportunities in future, looking forward to ascertain the specific activity of different somatic cell types with or without the existence of various multi‐kingdom microbiota and their by‐products and supply a holistic and elaborate investigation of host‐microbiota interaction in the development of cancer.
Impact of COVID‐19 pandemic on mortality rate in memory clinic patients
Authors: Bakker Els D. , van Maurik Ingrid S. , Zwan Marissa D. , Gillissen Freek , van der Veere Pieter J. , Bouwman Femke H. , Pijnenburg Yolande A. L. , van der Flier Wiesje M. 
Published: January 2024

AbstractINTRODUCTIONWe investigated whether mortality in memory clinic patients changed due to coronavirus disease 2019 (COVID‐19) pandemic.METHODSWe included patients from the Amsterdam Dementia Cohort: (1) n = 923 pandemic patients (baseline visit: 2017–2018, follow‐up: until 2021), and (2) n = 830 historical control patients (baseline visit: 2015–2016, follow‐up: until 2019). Groups were well‐balanced. We compared mortality during pandemic with historical control patients using Cox regression. Differences in cause of death between groups were explored using Fisher's exact test.RESULTSPandemic patients had a higher risk of mortality than historical control patients (hazard ratio [HR] [95% confidence interval {CI}] = 1.34 [1.05–1.70]). Stratified for syndrome diagnosis, the effect remained significant in dementia patients (HR [95% CI] = 1.35 [1.03–1.78]). Excluding patients who died of COVID‐19‐infection, the higher mortality risk in pandemic patients attenuated (HR [95% CI] = 1.24 [0.97–1.58]). Only the difference in cause of death between pandemic patients and historical control patients for death to COVID‐19‐infection (p = 0.001) was observed.CONCLUSIONMemory clinic patients had increased mortality risk during COVID‐19 compared to historical control patients, attributable to dementia patients.Highlights
We investigated if mortality rates in memory clinic patients changed due to COVID‐19 pandemic.
We included patients along the cognitive continuum, including SCD, MCI, and dementia.
We used a well‐balanced historical control group.
Memory clinic patients had higher risk for mortality during COVID‐19 lockdown.
Our results indicate that excess mortality is mainly caused by death to COVID‐19 infection.
Midlife sensory and motor functions improve long‐term predictions of cognitive decline and incidence of cognitive impairment
Authors: Schubert Carla R. , Pinto A. Alex , Paulsen Adam J. , Chappell Richard J. , Chen Yanjun , Engelman Corinne D. , Ferrucci Luigi , Hancock Laura M. , Johnson Sterling C. , Merten Natascha 
Published: January 2024

AbstractINTRODUCTIONWe aimed to assess whether midlife sensory and motor functions improve risk prediction of 10‐year cognitive decline and impairment when added to risk prediction models using the Cardiovascular Risk Factors, Aging, and Incidence of Dementia Score (CAIDE) and Framingham Risk Score (FRS).METHODSLongitudinal data of N = 1529 (mean age 49 years; 54% women) Beaver Dam Offspring Study (BOSS) participants from baseline, 5 and 10‐year follow‐up were included. We tested whether including baseline sensory (hearing, vision, olfactory) impairment and motor function improves CAIDE or FRS risk predictions of 10‐year cognitive decline or cognitive impairment incidence using logistic regressions.RESULTSAdding sensory and motor measures to CAIDE‐only and FRS‐only models significantly improved areas under the curve for cognitive decline and impairment models.DISCUSSIONIncluding midlife sensory and motor function improved risk predictions of long‐term cognitive decline and impairment in middle‐aged to older adults. Sensory and motor assessments could contribute to cost‐effective and non‐invasive screening tools that identify high‐risk individuals earlier to target intervention and prevention strategies.Highlights
Sensory and motor measures improve risk prediction models of cognitive decline.
Sensory and motor measures improve risk prediction models of cognitive impairment.
Prediction improvements were strongest in midlife (adults < 55 years of age).
Sensory and motor changes may help identify high‐risk individuals early.
Examining the biological impacts of parent–child relationship dynamics on preschool‐aged children who have experienced adversity
Authors: Coe Jesse L. , Daniels Teresa , Huffhines Lindsay , Seifer Ronald , Marsit Carmen J. , Kao Hung‐Teh , Porton Barbara , Parade Stephanie H. , Tyrka Audrey R. 
Published: January 2024

AbstractParent–child relationship dynamics have been shown to predict socioemotional and behavioral outcomes for children, but little is known about how they may affect biological development. The aim of this study was to test if observational assessments of parent–child relationship dynamics (cohesion, enmeshment, and disengagement) were associated with three biological indices of early life adversity and downstream health risk: (1) methylation of the glucocorticoid receptor gene (NR3C1), (2) telomere attrition, and (3) mitochondrial biogenesis, indexed by mitochondrial deoxyribonucleic acid (DNA) copy number (mtDNAcn), all of which were measured in children's saliva. We tested hypotheses using a sample of 254 preschool‐aged children (M age = 51.04 months) with and without child welfare‐substantiated maltreatment (52% with documented case of moderate‐severe maltreatment) who were racially and ethnically diverse (17% Black, 40% White, 23% biracial, and 20% other races; 45% Hispanic) and from primarily low‐income backgrounds (91% qualified for public assistance). Results of path analyses revealed that: (1) higher parent–child cohesion was associated with lower levels of methylation of NR3C1 exon 1D and longer telomeres, and (2) higher parent–child disengagement was associated with higher levels of methylation of NR3C1 exon 1D and shorter telomeres. Results suggest that parent–child relationship dynamics may have distinct biological effects on children.
A Novel Synthesis of Soluble, Stable Derivatives of the Perchlorinated Trityl Radical
Authors: Bushby Richard J. 
Published: January 2024

AbstractA new approach to the synthesis of derivatives of the perchlorinated tritryl radical is described. It relies on the fact that, under the conditions required to fully chlorinate the ortho positions of a triarylmethane, there is only minimal substitution of aryl fluorine by chlorine and then on the fact that, in the mixed Cl/F substituted triarylmethanes obtained, it is possible to selectively substitute the fluorine‐bearing positions using the sodium salt of n‐hexanol in n‐hexanol/dimethylsulfoxide. The meta‐hexyloxy derivatives obtained are much more soluble and photostable than the parent perchlorotrityl radical. For example, the introduction of four meta‐hexyloxy substituents gives a radical where, under white light illumination, the lifetime is improved by a factor of almost 104. The photostability of the radical, the lifetime of the excited state and the fluorescence all decrease as the number of meta‐hexyloxy substituents is increased. The improvements in solubility and in photostability observed should help in creating a more diverse range of perchlorotrityl radical derivatives and in the development of new applications.
Stimulus‐responsive and task‐dependent activations in occipital regions during pitch perception by early blind listeners
Authors: Pang Wengbin , Xia Zhichao , Zhang Linjun , Shu Hua , Zhang Yang , Zhang Yumei 
Published: January 2024

AbstractAlthough it has been established that cross‐modal activations occur in the occipital cortex during auditory processing among congenitally and early blind listeners, it remains uncertain whether these activations in various occipital regions reflect sensory analysis of specific sound properties, non‐perceptual cognitive operations associated with active tasks, or the interplay between sensory analysis and cognitive operations. This fMRI study aimed to investigate cross‐modal responses in occipital regions, specifically V5/MT and V1, during passive and active pitch perception by early blind individuals compared to sighted individuals. The data showed that V5/MT was responsive to pitch during passive perception, and its activations increased with task complexity. By contrast, widespread occipital regions, including V1, were only recruited during two active perception tasks, and their activations were also modulated by task complexity. These fMRI results from blind individuals suggest that while V5/MT activations are both stimulus‐responsive and task‐modulated, activations in other occipital regions, including V1, are dependent on the task, indicating similarities and differences between various visual areas during auditory processing.
Effectiveness and risk of second primary malignancies after radiotherapy in major salivary gland carcinomas: A retrospective study using SEER database
Authors: Feng Yuan , Qian Kai , Guo Kai , Shi Yuan , Zhou Jiaqing , Wang Zhuoying 
Published: January 2024

AbstractObjectiveTo investigate the effectiveness of radiotherapy and its association with second primary malignancies (SPMs) risk in major salivary gland carcinomas (MSGCs) patients.MethodsCohort 1 included 7274 surgically treated MSGC patients from the Surveillance, Epidemiology, and End Results database, assessing the effectiveness of radiotherapy. Cohort 2 (n = 4213) comprised patients with ≥5‐year survival in Cohort 1 to study SPMs.ResultsRadiotherapy decreased overall survival in MSGCs patients, but improved it in high‐grade MSGCs. Cumulative SPMs incidences at 25 years were 16.5% in the radiotherapy (RT) group compared to 14.5% in the non‐radiotherapy (NRT) group. For second head and neck carcinomas (SHNCs), incidences were 3.4% in RT versus 1.6% in NRT. Radiotherapy increased the relative risks of tumors, particularly SHNCs (RR = 1.78). The 10‐year OS rates of SHNCs after radiotherapy were significantly lower.ConclusionRadiotherapy improves survival in advanced‐stage MSGCs but increases the risk of developing SPMs, particularly SHNCs.
Can mid‐level providers manage medical abortion after 12 weeks' gestation as safely and effectively as physicians? A non‐inferiority, randomized controlled trial in Addis Ababa, Ethiopia
Authors: Kapp Nathalie , Dijkerman Sally , Getachew Abrham , Eckersberger Elisabeth , Pearson Erin , Abubeker Ferid A. , Birara Malede 
Published: January 2024

AbstractObjectiveTo determine whether clinical outcomes among clients undergoing medical abortion after 12 weeks' gestation differ by provider cadre.MethodsRandomized controlled trial conducted among eligible clients seeking abortion between 13 and 20 weeks' gestation. Participants seeking in‐facility abortion were randomized to receive care from a mid‐level provider (nurse/midwife) or physician. The primary outcome was median time to expulsion with non‐inferiority margin of −1.5 h between provider groups. Quantile median regression models assessed non‐inferiority. Secondary outcomes included retained placenta, complications, and patient acceptability.ResultsAfter randomization and eligibility assessment by the provider, 171 women participated in the study: 81 in the physician group and 90 in the mid‐level provider group. Their average age was 24 years, the mean gestational age was 16 weeks, and 65% were nulliparous in both groups. The median time to expulsion did not differ significantly, being 8.1 h for the mid‐level group and 6.6 h for the physician group. The adjusted median difference was 0.8 h (95% confidence interval [CI] –1.15 to 2.66), within the non‐inferiority margin. Retained placenta occurred similarly: 30.0% (n = 24) of the physician group and 20.5% (n = 18) of the mid‐level provider group (adjusted risk difference [ARD] 7.6%, 95% CI –2.81 to 18.06). Complications occurred in 7% of cases, including 5.0% (n = 4) of patients in the physician group and 8.9% (n = 8) in the mid‐level provider group (ARD –4.7%, 95% CI –12.43 to 3.12). Patient acceptability did not differ by group.ConclusionsTraining mid‐level providers to provide abortion services after 12 weeks' gestation independently of physicians is feasible and may result in comparable clinical outcomes.
Characterization of aTiO2 surfaces functionalized with CAP‐p15 peptide
Authors: Ureiro‐Cueto Guadalupe , Rodil Sandra E. , Santana‐Vázquez Maricela , Hoz‐Rodriguez Lia , Arzate Higinio , Montoya‐Ayala Gonzalo 
Published: January 2024

AbstractFunctionalization of Titanium implants using adequate organic molecules is a proposed method to accelerate the osteointegration process, which relates to topographical, chemical, mechanical, and physical features. This study aimed to assess the potential of a peptide derived from cementum attachment protein (CAP‐p15) adsorbed onto aTiO2 surfaces to promote the deposition of calcium phosphate (CaP) minerals and its impact on the adhesion and viability of human periodontal ligament cells (hPDLCs). aTiO2 surfaces were synthesized by magnetron sputtering technique. The CAP‐p15 peptide was physically attached to aTiO2 surfaces and characterized by atomic force microscopy, fluorescence microscopy, and water contact angle measurement. We performed in vitro calcium phosphate nucleation assays using an artificial saliva solution (pH 7.4) to simulate the oral environment. morphological and chemical characterization of the deposits were evaluated by scanning electronic microscopy (SEM) and spectroscopy molecular techniques (Raman Spectroscopy, ATR‐FTIR). The aTiO2 surfaces biofunctionalized with CAP‐p15 were also analyzed for hPDLCs attachment, proliferation, and in vitro scratch‐healing assay. The results let us see that the homogeneous amorphous titanium oxide coating was 70 nanometers thick. The CAP‐p15 (1 μg/mL) displayed the ability to adsorb onto the aTiO2 surface, increasing the roughness and maintaining the hydrophilicity of the aTiO2 surfaces. The physical adsorption of CAP‐p15 onto the aTiO2 surfaces promoted the precipitation of a uniform layer of crystals with a flake‐like morphology and a Ca/P ratio of 1.79. According to spectroscopy molecular analysis, these crystalline deposits correspond to carbonated hydroxyapatite. Regarding cell behavior, the biofunctionalized aTiO2 surfaces improved the adhesion of hPDLCs after 24 h of cell culture, achieving 3.4‐fold when compared to pristine surfaces. Moreover, there was an increase in cell proliferation and cell migration processes. Physical adsorption of CAP‐p15 onto aTiO2 surfaces enhanced the formation of carbonate hydroxyapatite crystals and promoted the proliferation and migration of human periodontal ligament‐derived cells in in vitro studies. This experimental model using the novel bioactive peptide CAP‐p15 could be used as an alternative to increasing the osseointegration process of implants.
CEO characteristics and bank stability: Evidence from an emerging economy
Authors: Hai Nam Pham , Diem Chi Le Ha 
Published: January 2024

AbstractThis paper investigates the effect of CEO characteristics on bank stability of commercial banks in Vietnam. The study used regression models Pooled OLS, Fixed effects Model (FEM), random effects model (REM), and Feasible Generalized Least Square (FGLS) to evaluate the relationship between CEO characteristics and bank stability of 26 commercial banks in Vietnam. To deal with the limitations of traditional regression methods, we propose Bayesian regression method. The data collection period in the study is from 2013 to 2022. In these regression models, CEO power, female CEO, CEO tenure, and CEO age are independent variables. The dependent variable representing bank stability is the Z‐score. The research results show that the factors CEO power, female CEO, CEO tenure, CEO age have a positive impact on bank stability in Vietnam.
A neural network potential based on pairwise resolved atomic forces and energies
Authors: Kalayan Jas , Ramzan Ismaeel , Williams Christopher D. , Bryce Richard A. , Burton Neil A. 
Published: January 2024

AbstractMolecular simulations have become a key tool in molecular and materials design. Machine learning (ML)‐based potential energy functions offer the prospect of simulating complex molecular systems efficiently at quantum chemical accuracy. In previous work, we have introduced the ML‐based PairF‐Net approach to neural network potentials, that adopts a pairwise interatomic scheme to predicting forces within a molecular system. Here, we further develop the PairF‐Net model to intrinsically incorporate energy conservation and couple the model to a molecular mechanical (MM) environment within the OpenMM package. The updated PairF‐Net model yields energy and force predictions and dynamical distributions in good agreement with the rMD17 dataset of ten small organic molecules in the gas‐phase. We further show that these in vacuo ML models of small molecules can be applied to force predictions in aqueous solution via hybrid ML/MM simulations. We present a new benchmark dataset for these ten molecules in solution, obtained from QM/MM simulations, which we denote as rMD17‐aq (https://zenodo.org/records/10048644); and assess the ability of PairF‐Net to reproduce the molecular energy, atomic forces and dynamical distributions of these solution conformations via ML/MM simulations.
Mental health screening and referral to treatment in dental practices: A scoping review
Authors: Culmer Nathan P. , Smith Todd Brenton , Berryhill M. Blake , Gurenlian JoAnn , Simpson Lance , Ogden Shawnna , Parrish Jonathan , Ryan Lacey , White Nicole , Bettis Merrill , Greenwood Charlotte 
Published: January 2024

AbstractObjectiveThe purpose of this study was to conduct a scoping review to examine and summarize the characteristics of research related to mental health (MH) screenings and/or referrals to treatment in dental practices.MethodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines for Scoping Reviews and searched multiple databases for terms connected with dental care, MH concerns, screening, and referral. Included articles: (1) described care provided in a dental practice, (2) described a situation where the patient is experiencing the potential MH problem, (3) did not involve dental anxiety exclusively, and (4) involved some form of MH screening and/or referral to treatment. Article analysis included a summary of key study characteristics, types of evidence, study design, and central concepts and definitions.ResultsThe search generated 2050 records, with 26 ultimately included. Most studies involved only adults (22, 85%), but only three (12%) reported on rurality (two urban; one mixed) and only two each (8%) reported race or ethnicity. Fifteen (58%) articles were prospective and 11 (42%) were retrospective. The studies varied widely in study designs, from 11 (42%) cross‐sectional methodologies to only one (4%) randomized controlled trial. Thirty‐four screening tools were used to screen for symptoms of 43 MH conditions, with depression and anxiety screened for most frequently. Few articles discussed making referrals, practice workflows, or follow‐up outcomes.ConclusionsIncluded studies provide evidence of viable options for dental practitioners regarding MH screening, referring, and conducting follow‐up, but lack specificity regarding these processes. Overall, more research is needed to clarify what workflows are most efficient for dental practitioners and efficacious in identifying patients with MH concerns.