bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibula free flap for mandibular reconstruction following total en bloc resection in ameloblastoma: a case report and literature review
Authors: Laksmi Putu Pradnyasanti , Tillasman Natassya Sandra , Hamid Agus Roy Rusly Hariantana , Rooseno Ratna Rayeni Natasha 
Published: November 2023

Background: The fibular free flap is considered the gold standard in mandibular bone reconstruction. It has a high survival rate, is well-vascularized, and fits seamlessly into long-bone defects. The purpose of this article is to describe the use of vascularized fibular free flap in mandibular reconstruction after total en bloc resection in case of ameloblastoma suspected of repeated trauma to the mandible.
Method: A case report of a 26-year-old patient undergoing a mandibular reconstruction using fibula osteocutenous free flap following total en bloc resection due to ameloblastoma on mandibular symphisis region was monitored using Doppler ultrasound every 15 minutes for three to five days.
Result: Within four months of treatment, the patient had improved, and the graft was found to be viable.
Conclusion: The severity and size of the affected tissue, the tumour's histological arrangement, and the consequences were the influence of whether or not ameloblastoma patients should require surgery. To determine the best course of treatment for each individual case of ameloblastoma, an accurate clinical examination and image evaluation are required.
Antibiogram of Acinetobacter baumannii isolated from Intensive Care Unit at Prof. dr. I.G.N.G. Ngoerah Hospital in 2020-2022
Authors: Setyojatmiko Indramawan , Fatmawati Ni Nengah Dwi , Tarini Ni Made Adi 
Published: November 2023

Background: Acinetobacter baumannii infection is a severe problem since it tends to be multi-resistant to many antibiotics. This study aimed to determine the prevalence of A. baumannii isolated from blood, urine, and sputum cultures and their antibiotic resistance patterns.
Methods: Data of A. baumanii isolated from clinical specimens of Intensive Care Unit (ICU) wards patients were collected retrospectively from laboratory records in the Clinical Microbiology Department of Prof. Dr. I. G. N. G. Ngoerah General Hospital during 2020-2022. Identification and antimicrobial susceptibility tests were conducted using the Vitek-2 Compact system (bioMérieux, France). Isolates resistant to ≥ 3 antibiotic classes were categorized as multidrug-resistant (MDR) A. baumanii.
Results: A. baumanii collected from sputum, blood, and urine in Intensive Care Unit (ICU) wards were 63%, 13%, and 7.5% from 2020 until 2022. Most A. baumanii isolates in 2020, 2021, and 2022 were susceptible to Amikacin, which was 75%, 78%, and 76%, respectively. Furthermore, the isolates that were susceptible to Trimethoprim/Sulfamethoxazole were 66%, 81%, and 72%, followed by Tigecycline, 80%, 61%, and 56% respectively. A. baumanii, however, showed low sensitivity to Meropenem even though susceptibility is getting higher each year. Almost all the isolates were resistant to ceftriaxone.
Conclusions: Acinetobacter baumannii isolates isolated during 2020-2022 showed high resistance to penicillin, cephalosporin and fluoroquinolones. Although A. baumanii was resistant to carbapenem, its susceptibility tends to increase throughout the 3 years of this study. These data could be considered for empirical therapy of A. baumanii infections.
Supraventricular tachycardia in pregnancy: a rare case series and dilemmatic antiarrhythmic drug choices in the rural area
Authors: Nugraha Putra Ngurah Agung Reza Satria , Arjawa Ida Bagus Komang , Prabawa Aditya 
Published: November 2023

Background: The prevalence of cardiovascular disease in pregnancy is reported to be increasing and becoming a major cause of maternal morbidity and mortality. The incidence of arrhythmia during pregnancy has been linked to increased fetal mortality and complications. Arrhythmias can develop de novo during pregnancy or be exacerbated by pregnancy.
Case Description: A 35-year-old (third trimester) and a 25-year-old (second trimester) woman complained of shortness of breath and palpitations. The first patient was in her sixth pregnancy, with three live births and two miscarriages. Meanwhile, the second patient was in her first pregnancy and had never miscarried. The first and second patients' pulse rates were 180 and 160 beats per minute, respectively. In both cases, 12-lead electrocardiography revealed an atrioventricular nodal re-entrant tachycardia rhythm. Initially, both patients were given carotid artery massages. The first patient's rhythm returned to normal sinus, but carotid artery massage failed in the second patient. Then, the second patient received a slow bolus of 0.5 mg digoxin IV. The heart rate returned to normal sinus rhythm following the observation. Both patients were admitted to the intensive care unit.
Conclusion: Atrioventricular nodal re-entrant tachycardia is a type of paroxysmal supraventricular tachycardia. Effective management highly depends on both clinical presentation and the trimester of pregnancy. This arrhythmia can be treated with vagal maneuvers in mild cases. When vagal maneuvers fail, medical management is preferred. The main concern with using antiarrhythmic drugs during pregnancy is the risk of fetal harm and the decision should be tailored based.
Temuan insidental mitral annular disjunction: laporan kasus dan tinjauan kepustakaan
Authors: Wulan Sari Ni Made Ayu , Wisuda I Wayan Prasetya 
Published: November 2023

Introduction: Mitral annular dysjunction (MAD) is a structural abnormality in the mitral valve which can result in various other pathologies such as ventricular arrhythmias and sudden cardiac death.
Case illustration: An incidental finding in a 61 year old woman with mammary carcinoma who underwent trans thoracic echocardiography evaluation, with findings of left atrial dilatation, mild mitral regurgitation, and mitral annular displacement. The patient did not have any significant heart rhythm abnormalities.
Conclusion: MAD is a structural abnormality that is defined as detachment of the continuity of the mitral annulus-left atrial wall with the basal aspect of the posterolateral LV. This is often found in patients with myxomatous mitral valve degeneration and mitral valve prolapse (MVP).

Pendahuluan: Mitral annular dysjunction (MAD) merupakan suatu kelainan structural pada katup mitral yang dapat mengakibatkan berbagi patologi lainnya seperti aritmia ventrikel dan kematian jantung mendadak.
Ilustrasi kasus: Sebuah temuan incidental pada wanita usia 61 tahun dengan Karsinoma mamae yang dilakukan evaluasi ekokardiografi trans thorakal, dengan temuan adanya dilatasi atrium kiri, mitral reguritasi ringan, dan mitral annular displacement. Pasien tidak memiliki suatu kelainan irama jantung yang bermakna.
Simpulan: MAD adalah kelainan struktural yang diartikan sebagai pelepasan kontinuitas anulus mitral-dinding atrium kiri dengan aspek basal dari LV posterolateral. Hal ini seringkali dijumpai pada pasien dengan degenerasi katup mitral miksomatus dan mitral valve prolapse (MVP).
A hybrid process for integration of organic electrochemical transistors for high uniformity & reliability
Authors: Meier Tommy , Yoon Yeohoon , Teuerle Laura , Solgi Ali , Leo Karl , Kleemann Hans 
Published: November 2023

AbstractPhotolithography is believed to be a complementary technique to large-area printing, allowing for nanometer-scale integration and offering cost-efficiency. For organic electronics though, adapting photolithography is very challenging due to chemical incompatibilities. However, with the help of Alexander Zakhidov, orthogonal resins opened up the prospect of adapting the well-established process of photolithography for organic electronics. Here, we present a hybrid fabrication method for organic electrochemical transistors by combining orthogonal photolithography and inkjet printing, enabling high uniformity and reliability. We demonstrate how the resolution of each process affects the uniformity, and we explore the advantages of this process for device scaling and circuit integration.
Graphical abstract
Viddha karma in timira roga - A single case study
Authors: Sengaonkar Kirti , Rahinj Santosh , Shiralkar Mayur , Kale Anand , Ghosh Atri 
Published: November 2023

Conditions with gradual loss of vision leading to blindness, is considered as Timira (Myopic Astigmatism). The clinical features of timira are dominated by the type of dosha vitiated where as the severity of the disease is dependant upon the number of patalas involved. As per Acharya Vagbhatta Drishti Mandal of Netra is developed from Kapha and Rakta[1]. Drishti Indriya is also developed from Teja Mahabhuta[2]. A case study of Timira Roga had been taken for understanding the effect of Vidhha Karma in Timira roga presented by a 21-year old female who came to Shalakya Netra roga OPD in Dr. D.Y. Patil College of Ayurved & Research Centre, Pimpri, Pune – 18 of Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune (Deemed to be University), Maharashtra, India. Alochaka pitta is situated in netra. Rakta dhatu is the ashray sthana of pitta dosha as per ashrayaashrayi bhaav. In Timira roga, vitiated dosha which is located at the patala comes out with the rakta by the help of sira-vedhana. Sira vedhana or viddha karma causes samprapti- bhang of timira roga and gives clear vision to the patient. In vidhha karma, avyakta rakta srava is always attained, therefore vidhha karma is useful in timira roga.
A Prospective-Comparative Study on Extremity of Stroke in Patients with and Without Atrial Fibrillation as a Clinical Predictor
Authors: G Ramya Balaprabha  , J Jeevaniya Anil  , G Surya Kiran Reddy  , Aryamal Pillai  , T Rama Rao  
Published: November 2023

Background: Atrial fibrillation (AF) is a leading cause of ischemic stroke. It is critical to confirm the impact of AF on stroke outcomes. Objective: To assess the risk factors for stroke in conditions with or without atrial fibrillation. • To compare stroke severity and outcomes in stroke patients with or without atrial fibrillation. • To assess the vascular risk factors and co-morbid conditions Method: Analysis of the patient's medical information, such as age, gender, kind of stroke, location, mode of therapy, severity, and results. antithrombotic therapy) on 100 stroke victims (50 of them who exhibited AF and the other 50 without). Results: Age 61 to 80 were associated with a greater risk of strokes (33% non-AF, 14% AF), while age groups 81 and above were associated with a higher chance of atrial fibrillation (2% AF).men and females had the same incidence of AF (12% each), with the exception that females were more common in the non-AF group (47%) than men (29%). Patients with ischemic stroke were more prevalent (73%), but patients with hemorrhagic stroke (6% AF, 9% non-AF) were more likely to have it. The CHAD2DS2-VASc SCORE and AH showed that hypertensive people had a greater risk of stroke in both the AF (10%) and non-AF (46%) groups. Overall, the AF (10%) and non-AF (46%) groups had hypertension as the most common co-morbid disease, with antihypertensive medications being the commonest prescribed medicine (23% AF, 59% non-AF). Conclusion: The study concluded that if treatment methods for atrial fibrillation and stroke are given, patient outcomes can be improved with sufficient assessment and strict adherence.
Coherent Spatial Variations in the Productivity of Earthquake Sequences in California and Nevada
Authors: Trugman Daniel T. , Ben-Zion Yehuda 
Published: November 2023

Abstract
Earthquakes are clustered in space and time, with individual sequences composed of events linked by stress transfer and triggering mechanisms. On a global scale, variations in the productivity of earthquake sequences—a normalized measure of the number of triggered events—have been observed and associated with regional variations in tectonic setting. Here, we focus on resolving systematic variations in the productivity of crustal earthquake sequences in California and Nevada—the two most seismically active states in the western United States. We apply a well-tested nearest-neighbor algorithm to automatically extract earthquake sequence statistics from a unified 40 yr compilation of regional earthquake catalogs that is complete to M ∼ 2.5. We then compare earthquake sequence productivity to geophysical parameters that may influence earthquake processes, including heat flow, temperature at seismogenic depth, complexity of quaternary faulting, geodetic strain rates, depth to crystalline basement, and faulting style. We observe coherent spatial variations in sequence productivity, with higher values in the Walker Lane of eastern California and Nevada than along the San Andreas fault system in western California. The results illuminate significant correlations between productivity and heat flow, temperature, and faulting that contribute to the understanding and ability to forecast crustal earthquake sequences in the area.
Ileal metastasis masquerading as Crohn’s in lobular carcinoma of the breast, years after initial treatment and review of literature
Authors: Haji Altaf G. , Vijayaraghavalu Shashikanth , Sivakumar Naveen , Zehra Sadaf , Marimuthu Kalimuthu , Selvam Lourdusamy Arul , Piramanayagam Bala 
Published: November 2023

Gastrointestinal (GI) metastases masquerading as Crohn’s years after treated lobular carcinoma of breast is a diagnostic challenge. In some cases, the interval between the primary breast cancer and gastrointestinal metastasis is so long (3-20 years) that the medical records for diagnosis including history might be missed. The susceptibility of invasive lobular cancer (ILC) to metastasize to gut is many times greater than invasive ductal carcinoma (IDC) (4.5% versus 0.2%, respectively). We report the case of lobular breast carcinoma metastasizing to the terminal ileum and ileocecal junction 7 years following treatment of right sided lobular breast cancer in 60 plus-year-old women. Radiological and endoscopic findings can be difficult to distinguish from inflammatory bowel disease or from primary carcinoma of the GI tract. Histopathological and immunochemistry assessments usually help in reaching the diagnosis. A high index of suspicion and awareness regarding such presentations can help in making an accurate diagnosis and subsequent treatment planning.
Tendencias pedagógicas en las prácticas de formación de licenciados en Educación Básica modalidad a distancia y virtual
Authors: Torres Ortíz Jaime Andrés 
Published: November 2023

El trabajo de investigación doctoral que deriva en este libro, presenta aportes y hallazgos en torno a las tendencias pedagógicas en las prácticas de formación de licenciados en Educación Básica, todas ellas como parte de una práctica educativa inmersa en el ámbito de la educación a distancia y virtual. Estas tendencias marcan una práctica que se integra a los cambios sociales, culturales y tecnológicas que intervienen en la formación de maestría. Se analizan e interpretan de antemano las corrientes tradicionales de la pedagogía, como son el conductismo, la tecnología educativa, el cognitivismo, el socioconstructivismo y el huimanismo, entre otros. Posteriormente, se hace un acercamiento holístico, acompañado del paradigma cualitativo y el enfoque etnográfico soportado en la hermenéutica, como parte de la racionalidad interpretativa que acompaña al autor.
Isolation and molecular characterization of Acanthamoeba spp. from Iraqi patients with Keratitis
Authors: Aldin Muna B. , Ardalan Naksheen M. , Jassim Khudair Abbas 
Published: November 2023

تعتبرAcanthamoeba من أكثر الطفيليات انتشارًا وهي على اتصال دائم مع الانسان والحيوان تتكون دورتها من مرحلتين هما الطور الخضري (الناشطة) والطور المتكيس. تضمنت الدراسة الحالية على عزل طفيلي Acanthamoeba الموجودة في قرنية العين. تم جمع ستة وتسعين عينة سريرية من مرضى التهاب القرنية من مستشفى (ابن الهيثم التخصصي) في بغداد للفترة من تشرين الثاني 2020 إلى نهاية أيار 2021 لعزل وتشخيص طفيلي Acanthamoeba، ولقد تم زرع جميع العينات على أوساط تفريقيه، فبعد أخذ العينات عن طريق قشط القرنية أو المسحات، تم نقلها إلى اوساط أجار غير مغذية ANN)) تحتوي على معلق E. coli المعطلة بالحرارة وحضنت لمدة 14 يومًا عند 37 درجة مئوية. ثم تم فحص جميع الاطباق وتصنيفها على أنها تحديد شكلي إيجابي أو سلبي للتعرف شكليا على Acanthamoeba spp. ولم يلاحظ وجود الفطريات فيها. ومن ثم تم إجراء تحليل تفاعل البلمرة المتسلسل (PCR) وتسلسل لتحديد أنواع عزلات Acanthamoeba. بعد تحليل (PCR)، وتحليل جزء DF3 جعل من الممكن تصنيف السلالات الثلاثة من جنس Acanthamoeba، ثم تم إجراء تحليل التسلسل باستخدام أداة NCBI، والتي أظهرت وجود طرازين وراثية مختلفة، تم تجميع سلالتين في النمط الجيني T3، واحدة من T4، ثم تم تسجيلها في GeneBank تحت أرقام المدخلات على التوالي (MZ427912، MZ349042).
التحقق من مصدوقية طريقة تحليل S-phenyl mercapturic acid بالبول باستخدام الاستشراب السائل عالي الأداء مع كاشف الصمام الثنائي الضوئي
Authors: Albitar Mohammad Nour , Barguil Sophie 
Published: November 2023

تم تطوير وتوثيق مصدوقية طريقة تحليلية باستخدام جهاز الاستشراب السائل عالي الأداء HPLC تتمتع بالبساطة والانتقائية والدقة وذلك من أجل تعيين حمض س-فينيل ميركابتوريك. حُقّق الفصل الاستشرابي بواسطة استخدام عمود فصل من نوع (ODS-3 Inertsil) بأبعاد (5μ, 150 mm x 4.6 mm). وكانت درجة حرارة العمود 45 درجة مئوية. واستُخدم طور متحرك مؤلف من أسيتونتريل: ميتانول: ماء منزوع الشوارد محمض بحمض فوق الكلور (4/1/5 حجم/ حجم/حجمpH=3 ,) بمعدل جريان 1.5 مل/دقيقة واستخدام طول موجة مكشاف 225 نانومتر. أُجريت اختبارات ملاءمة النظام لتقييم مدى ملاءمة وفعالية النظام الاستشرابي بأكمله. حُسب زمن احتباس مادتي حمض س-فينيل ميركابتوريك وحمض البنزوئيك فقد وجدتا 17.3 و 15.6دقيقة، على التوالي، وأُجري التحقق من مصدوقية الطريقة المطورة من حيث الخطية والدقة والمضبوطية والنوعية وحد الكشف وحد التقدير الكمي. حيث كان حد الكشف: 126.0 مكغ/مل وحد التقدير الكمي: 0.38 مكغ/مل لمادة س-فينيل ميركابتوريك، وبمردود97.183% :. أظهرت المادة استجابة خطية ضمن المجال 0.5-20 مكغ/مل. تهدف هذه الدراسة إلى تطوير طريقة تحليلية باستخدام جهاز الاستشراب عالي الأداء والتحقق من مصدوقيتها، ويمكن استخدام الطريقة المقترحة لتقدير مستقلب البنزن هذا في البول كونها بسيطة ودقيقة وانتقائية.
Solvability of the Quaternary Continuous Classical Boundary Optimal Control Dominated by Quaternary Parabolic System
Authors: Al-Hawasy Jamil A. Ali , Naji Fetan J. 
Published: November 2023

الهدف من هذا البحث هو دراسة قابلية الحل لمتجه السيطرة الامثلية الحدودية الرباعية التقليدية المستمرة المسيطرة بمسالة القيم الحدودية الغير خطية المكافئة بوجود قيود الحالة. تم ذكر وإثبات مبرهنة الوجود لمتجه السيطرة الامثلية الحدودية التقليدية المستمرة الرباعية مع قيدي التساوي والتباين للحالة وبوجود شروط ملائمة. تم ايجاد الصيغة الرياضية لمسالة القيم الحدودية الرباعية المرافقة والمصاحبة لمسالة القيم الحدودية الرباعية الغير خطية المكافئة . تم ايجاد مشتقة فريشيه لدالة الكلفة ولدوال القيود. بوجود شروط مناسبة تم ذكر نص واثبات مبرهنتي الشروط الضرورية والشروط الكافية لوجود متجهة السيطرة الامثلية الحدودية الرباعية المستمرة التقليدية.
A Multi-Objective Facility Coverage Location Problem for Emergency Medical Service Decisions in Hajj
Authors: Naji Huda Zaki , Al-Behadili Mohanad , Kadim Mohammad Sari 
Published: November 2023

يقترح هذا البحث نموذج منشأة متعدد الأغراض لمشكلة موقع التغطية لتحديد عدد ومواقع وعمليات إعادة نشر نظام EMS الذي يعمل مع سيارتي إسعاف من النوع: دعم الحياة المتقدم (ALS) ودعم الحياة الأساسي (BLS) . يأخذ نموذج التغطية متعددة الأغراض المقترح (MO-CL) في الحسبان هدفين: 1) خفض تكاليف نظام EMS عن طريق الحد من نوعي سيارات الإسعاف ALS و BLS. 2) تقليل إجهاد أعضاء طاقم EMS عن طريق الحد من عدد إعادة الانتشار لنوعين من سيارات الإسعاف مع الاستمرار في توفير مستويات التغطية المطلوبة. يمكن حل نموذج MO-CL من خلال تطبيق خوارزمية البحث MO-CL. يعتمد النموذج المقترح على نموذج المكعب الفائق التقريبي، والذي يلغي افتراضات تشغيل سيارة الإسعاف المستقلة واحتمال الانشغال على مستوى النظام. تم استخدام النموذج في دراسة حالة بناءً على بيانات حقيقية تم جمعها من مستشفى النور التخصصي في مكة المكرمة خلال فترة الحج التي استمرت 15 يومًا. لتحقيق عتبة تغطية 95 في المائة للطلب الحاسم وغير الحاسم ، يتطلب نموذج MO-CL ما لا يقل عن 64 سيارة إسعاف (29 ALS و 12 BLS احتياطيًا و 23 BLS) و 19 عملية إعادة نشر (9 ALS و 2 للنسخ الاحتياطي BLS ، و 8 BLS) كل يوم.
The Solution of Fermat’s Two Squares Equation and Its Generalization In Lucas Sequences
Authors: Athab Ali S. , Hashim Hayder R. 
Published: November 2023

من المعروف أن هناك عدد غير منتهي من الأعداد الأولية في أشكال خاصة مثل شكل مربع فيرما ، أو تعميمها الذي يحتوي على الشكل ، حيث تمثل المتغيرات و بعض الأعداد الصحيحة. الهدف الرئيسي من هذه الورقة هو التحقق مما إذا كانت الاشكال أعلاه لا تزال تحتوي على العديد من الحلول أم لا عندما تكون هذه المتغيرات مشتقة من متواليات تحتوي على عدد غير منتهي من الأعداد الأولية. بتعبير أدق ، تركز هذه الورقة على التحقيق في حلول هذه الأشكال عندما تمثل هذه المتغيرات مصطلحات في تسلسلات تكرار خطية ثنائية معينة تسمى متواليات لوكاس من النوع الأول والنوع الثاني.
Epistasis regulates genetic control of cardiac hypertrophy
Authors: Wang Qianru , Tang Tiffany , Youlton Nathan , Weldy Chad , Kenney Ana , Ronen Omer , Hughes John , Chin Elizabeth , Sutton Shirley , Agarwal Abhineet , Li Xiao , Behr Merle , Kumbier Karl , Moravec Christine , Tang W. H. Wilson , Margulies Kenneth , Cappola Thomas , Butte Atul , Arnaout Rima , Brown James , Priest James , Parikh Victoria , Yu Bin , Ashley Euan 
Published: November 2023

Abstract
The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy. We derive deep learning-based estimates of left ventricular mass from the cardiac MRI scans of 29,661 individuals enrolled in the UK Biobank. We report epistatic genetic variation including variants close to CCDC141, IGF1R, TTN, and TNKS. Several loci not prioritized by univariate genome-wide association analysis are identified. Functional genomic and integrative enrichment analyses reveal a complex gene regulatory network in which genes mapped from these loci share biological processes and myogenic regulatory factors. Through a network analysis of transcriptomic data from 313 explanted human hearts, we show that these interactions are preserved at the level of the cardiac transcriptome. We assess causality of epistatic effects via RNA silencing of gene-gene interactions in human induced pluripotent stem cell-derived cardiomyocytes. Finally, single-cell morphology analysis using a novel high-throughput microfluidic system shows that cardiomyocyte hypertrophy is non-additively modifiable by specific pairwise interactions between CCDC141 and both TTN and IGF1R. Our results expand the scope of genetic regulation of cardiac structure to epistasis.