bluuebunny/crossref_metadata_2025_split huggingface dataset:
The perfect storm: Cutaneous leishmaniasis in troops deployed in the Atlantic forest of Argentina
Authors: Lamattina Daniela , Couto Esteban Manuel , Moya Sofía Lorian , Giuliani Magalí Gabriela , Cortés Micaela , Vadell María Victoria , Salomón Oscar Daniel 
Published: February 2024

AbstractAmerican cutaneous leishmaniasis (ACL) is the most prevalent form of leishmaniasis, associated with an ulcerative and stigmatizing mucocutaneous pathology. This study assessed the incidence of Leishmania (Viannia) braziliensis in members of the Argentine Army who were exposed to sandfly bites in Iguazú National Park (INP), northeastern Argentina, during an outbreak of ACL in 2019, and the presence of Leishmania in rodents, opossums and phlebotomine sandflies collected in the area of exposure. Samples from military personnel, wild animals and phlebotomine sandflies were analysed. A total of 20 (40%) patients among the Army personnel and two Akodon montensis rodents (11%) were positive for the presence of Leishmania sp. genes by PCR, while Nyssomyia whitmani and Migonemyia migonei, competent vectors of Leishmania, were also found at the same site. Sequences of hsp70 DNA fragments obtained from human samples confirmed the identity of L. (V.) braziliensis. The risk to which military personnel carrying out activities in the forest are exposed is highlighted, and this risk extends to any worker and visitor who circulates without protection in the INP, coming into contact with transmission “hot spots” due to the concentration of vectors, reservoirs and/or parasites.
Enhanced or hindered research benefits? A realist review of community engagement and participatory research practices for non-communicable disease prevention in low- and middle-income countries
Authors: Klingberg Sonja , Adhikari Bipin , Draper Catherine E , Bosire Edna , Nyirenda Deborah , Tiigah Priscilla , Mukumbang Ferdinand C 
Published: February 2024

IntroductionCommunity engagement and participatory research are widely used and considered important for ethical health research and interventions. Based on calls to unpack their complexity and observed biases in their favour, we conducted a realist review with a focus on non-communicable disease prevention. The aim was to generate an understanding of how and why engagement or participatory practices enhance or hinder the benefits of non-communicable disease research and interventions in low- and middle-income countries.MethodsWe retroductively formulated theories based on existing literature and realist interviews. After initial searches, preliminary theories and a search strategy were developed. We searched three databases and screened records with a focus on theoretical and empirical relevance. Insights about contexts, strategies, mechanisms and outcomes were extracted and synthesised into six theories. Five realist interviews were conducted to complement literature-based theorising. The final synthesis included 17 quality-appraised articles describing 15 studies.ResultsWe developed six theories explaining how community engagement or participatory research practices either enhance or hinder the benefits of non-communicable disease research or interventions. Benefit-enhancing mechanisms include community members’ agency being realised, a shared understanding of the benefits of health promotion, communities feeling empowered, and community members feeling solidarity and unity. Benefit-hindering mechanisms include community members’ agency remaining unrealised and participation being driven by financial motives or reputational expectations.ConclusionOur review challenges assumptions about community engagement and participatory research being solely beneficial in the context of non-communicable disease prevention in low- and middle-income countries. We present both helpful and harmful pathways through which health and research outcomes are affected. Our practical recommendations relate to maximising benefits and minimising harm by addressing institutional inflexibility and researcher capabilities, managing expectations on research, promoting solidarity in solving public health challenges and sharing decision-making power.
Excellent response to anti-CD38 therapy with daratumumab in a patient with severe refractory CANOMAD
Authors: Pascual-Goñi Elba , Collet Roger , Tejada-Illa Clara , Martín-Aguilar Lorena , Caballero-Ávila Marta , Lleixà Cinta , Novelli Silvana , López-Pardo Jordi , Sanfeliu Albert Esquirol , Mariscal Anais , Álvaro Gargallo Yolanda , Martínez-Hernández Eugenia , Cocho Dolores , Querol Luis 
Published: February 2024

Background
Intravenous immunoglobulin (IVIG) and rituximab are considered the first-line and second-line treatments for Chronic Ataxic Neuropathy and Ophthalmoplegia with IgM-paraprotein, cold Agglutinins, and anti-Disialosyl antibodies (CANOMAD), with an overall clinical response around 50%. New anti-CD38 daratumumab, targeting long-lived plasma cells, has been reported as a promising therapy for treatment-refractory antibody-mediated disorders. We report the first case of a severe refractory CANOMAD, successfully treated with daratumumab.

Methods
A patient in their 70s with severe relapsing CANOMAD, refractory to IVIG, steroids, rituximab and ibrutinib developed severe tetraparesis and respiratory failure. Plasma exchange (PE) improved motor and ventilatory function; however, after 6 weeks, patient remained PE dependent. Intravenous daratumumab was initiated at 16 mg/kg weekly for 3 weeks, every 2 weeks for the second and third month, and monthly afterwards.

Results
After 3 weeks of starting daratumumab, PE was discontinued and, since then, the patient evolved to complete recovery. Antidisialosyl antibody titres decreased after PE and remained stable during daratumumab. Serum neurofilament light-chain levels were elevated in the exacerbation phase and normalised after daratumumab. The patient remains in clinical remission under monthly daratumumab, 12 months after initiation.

Conclusions
The first patient with aggressive treatment-refractory CANOMAD treated with daratumumab provides proof-of-principle evidence that daratumumab may be an effective treatment in IgM-related neuropathies.
Pain management in trauma: the need for trauma-informed opioid prescribing guidelines
Authors: Baltes Amelia , Horton David M , Malicki Julia , Trevino Colleen , Agarwal, Suresh , Zarzaur Ben L , Brown Randall T 
Published: February 2024

Background/objectivesSurgical populations and particularly injury survivors often present with complex trauma that elevates their risk for prolonged opioid use and misuse. Changes in opioid prescribing guidelines during the past several years have yielded mixed results for pain management after trauma, with a limiting factor being the heterogeneity of clinical populations and treatment needs in individuals receiving opioids. The present analysis illuminates this gap between clinical guidelines and clinical practice through qualitative feedback from hospital trauma providers and unit staff members regarding current opioid prescribing guidelines and practices in the setting of traumatic injury.MethodsThe parent study aimed to implement a pilot screening tool for opioid misuse in four level I and II trauma hospitals throughout Wisconsin. As part of the parent study, focus groups were conducted at each study site to explore the facilitators and barriers of implementing a novel screening tool, as well as to examine the current opioid prescribing guidelines, trainings, and resources available for trauma and acute care providers. Focus group transcripts were independently coded and analyzed using a modified grounded theory approach to identify themes related to the facilitators and barriers of opioid prescribing guidelines in trauma and acute care.ResultsThree major themes were identified as impactful to opioid-related prescribing and care provided in the setting of traumatic injury; these include (1) acute treatment strategies; (2) patient interactions surrounding pain management; and (3) the multifactorial nature of trauma on pain management approaches.ConclusionProviders and staff at four Wisconsin trauma centers called for trauma-specific opioid prescribing guidelines in the setting of trauma and acute care. The ubiquitous prescription of opioids and challenges in long-term pain management in these settings necessitate additional community-integrated research to inform development of federal guidelines.Level of evidenceTherapeutic/care management, level V.
Elements of Timed Pattern Matching
Authors: Ulus Dogan , Ferrère Thomas , Asarin Eugene , Nickovic Dejan , Maler Oded 
Published: February 2024

The rise of machine learning and cloud technologies has led to a remarkable influx of data within modern cyber-physical systems. However, extracting meaningful information from this data has become a significant challenge due to its volume and complexity. Timed pattern matching has emerged as a powerful specification-based runtime verification and temporal data analysis technique to address this challenge.
In this paper, we provide a comprehensive tutorial on timed pattern matching that ranges from the underlying algebra and pattern specification languages to performance analyses and practical case studies. Analogous to textual pattern matching, timed pattern matching is the task of finding all time periods within temporal behaviors of cyber-physical systems that match a predefined pattern. Originally we introduced and solved several variants of the problem using the name of match sets, which has evolved into the concept of timed relations over the past decade. Here we first formalize and present the algebra of timed relations as a standalone mathematical tool to solve the pattern matching problem of timed pattern specifications. In particular, we show how to use the algebra of timed relations to solve the pattern matching problem for timed regular expressions and metric compass logic in a unified manner. We experimentally demonstrate that our timed pattern matching approach performs and scales well in practice. We further provide in-depth insights into the similarities and fundamental differences between monitoring and matching problems as well as regular expressions and temporal logic formulas. Finally, we illustrate the practical application of timed pattern matching through two case studies, which show how to extract structured information from temporal datasets obtained via simulations or real-world observations. These results and examples show that timed pattern matching is a rigorous and efficient technique in developing and analyzing cyber-physical systems.
Deleting a Signal: Evidence from Pre-employment Credit Checks
Authors: Bartik Alexander W. , Nelson Scott T. 
Published: February 2024

Abstract
We study the removal of information from a market, such as a job-applicant screening tool. We characterize how removal harms groups with relative advantage in that information: typically those for whom the banned information is most precise relative to alternative signals. We illustrate this using recent bans on employers’ use of credit report data. Bans decrease job-finding rates for Black job-seekers by 3 percentage points and increase involuntary separations for Black new hires by 4 percentage points, primarily because other screening tools, such as interviews, have around 60% higher standard deviation of signal noise for Black relative to white job-seekers.
Examining Selection Pressures in the Publication Process through the Lens of Sniff Tests
Authors: Snyder Christopher M. , Zhuo Ran 
Published: February 2024

Abstract
Economics papers increasingly report balance, pre-trend, placebo, and other “sniff tests,” rejection of which is bad news for authors, undermining the credibility of their main results. We derive nonparametric bounds on the latent proportion of significant sniff tests removed by the publication process (whether by p-hacking or relegation to the file drawer) and the proportion whose significance was due to true misspecification, not bad luck. Using a hand-collected sample of nearly 30,000 sniff tests, we estimate a removal rate of over 30% for balance tests in randomized controlled trials and a misspecification rate of over 40% for other tests.
Difference-in-Differences Estimators of Intertemporal Treatment Effects
Authors: de Chaisemartin Clément , D'Haultfœuille Xavier 
Published: February 2024

Abstract
We study treatment-effect estimation using panel data. The treatment may be non-binary, non-absorbing, and the outcome may be affected by treatment lags. We make a parallel-trends assumption, and propose event-study estimators of the effect of being exposed to a weakly higher treatment dose for ℓ. periods. We also propose normalized estimators, that estimate a weighted average of the effects of the current treatment and its lags. We also analyze commonly-used two-way-fixed-effects regressions. Unlike our estimators, they can be biased in the presence of heterogeneous treatment effects. A local-projection version of those regressions is biased even with homogeneous effects.
How Big Is the Media Multiplier? Evidence from Dyadic News Data
Authors: Besley Timothy , Fetzer Thiemo , Mueller Hannes 
Published: February 2024

Abstract
This paper estimates the size of the media multiplier, an easily generalizable model-based measure of how far media coverage magnifies the economic response to shocks. We combine monthly aggregated and anonymized credit card activity data from 114 card issuing countries in 5 destination countries with a large corpus of news coverage in issuing countries reporting on violent events in the destinations. To define and quantify the media multiplier we estimate a model in which latent beliefs, shaped by either events or news coverage, drive card activity. According to the model, media coverage can more than triple the economic impact of an event. We document, through our model, that this effect is highly heterogenous and depends on the broader media representation of countries in each others news. We speculate about the role of the media in driving international travel patterns an.
Lowering the Playing Field: Discrimination through Sequential Spillover Effects
Authors: Kessler Judd B. , Low Corinne , Shan Xiaoyue 
Published: February 2024

Abstract
We document a new way that discrimination operates: through sequential spillover effects. Employers in an incentivized resume rating experiment evaluate a sequence of hypothetical candidates with randomly assigned characteristics. Candidates are rated worse when following white men than when following women or minorities. Exploring the mechanisms, we find that spillover effects are inversely related to direct bias. When reviewing high-quality resumes or recruiting in STEM industries, employers directly favor white men and display no spillover effect. For low-quality resumes or non-STEM industries, we find no direct bias but a strong spillover effect. Results suggest that discrimination arises in subtle ways.
The Unintended Consequences of Infrastructure Development
Authors: Bancalari Antonella 
Published: February 2024

Abstract
I investigate the social costs imposed by poor implementation of public infrastructure. Focusing on the period from 2005 to 2015 in Peru, when the government embarked on a nationwide initiative to expand sewerage systems, I leverage quasirandom variation in initiation of the implementation phase. By combining several sources of administrative data, I find that infrastructure development increased infant and under-5 mortality. These effects are driven by health and safety hazards associated with construction work, leading to increased deaths from accidents and waterborne diseases. The severity of these effects is more pronounced in areas where construction activity was more intense.
Information Transmission in Groups: Peer Influence in High-Stakes, Irreversible Financial Decisions
Authors: Ahn Tom , Cunha Jesse M. , Veith Patrick 
Published: February 2024

Abstract
We study the influence of workplace peers on a high-stakes, irreversible retirement plan choice. Mid-career U.S. military personnel choose between higher future pension pay-outs, or an immediate bonus plus lower future pay-outs. With peers defined as those who have locked-in their choices and personnel assignment rules ensuring that peer groups are exogenously formed, we capture the causal impact of peers. Greater peer take-up of the bonus, which is difficult to compare to the alternative plan but often extremely costly over one's lifetime, discourages choosers from selecting the bonus. Peers are especially impactful within professional, race, and gender groups.
Federal Tax Deductions and the Demand for Local Public Goods
Authors: Ambrose Brent W. , Valentin Maxence 
Published: February 2024

Abstract
The United States tax system allows taxpayers to deduct local taxes from their taxable incomes. Using school district referendum results, we employ a continuous treatment two-way fixed-effects framework to provide causal evidence of a positive relation between the demand for local public goods and the share of residents deducting local taxes. We find that a one-percentage-point decrease in the share of residents deducting property taxes reduces tax and bond referendum approval rates by approximately 0.97 percentage points. Because these federal tax deductions disproportionately benefit higher-income individuals, they potentially widen disparities in public service provision across jurisdictions.
Women and Law in Seventeenth-Century Mughal India
Authors: Hassan Basharat 
Published: February 2024

Abstract
This article examines a collection of notary documents referred to as the ‘Cambay Documents’. The ‘Cambay Documents’ is a collection of around fifty documents, registered between the second half of the seventeenth to the first half of the eighteenth century. These documents were acquired by the National Archives of India from a private collection and are now in the Oriental Section of the National Archives of India, New Delhi. We explored these documents to situate the legal position of women in Mughal India. These documents are of immense importance as they are related to the practice of law rather than theory. There is a dearth of such documents in modern repositories and archives, due to the absence of any centralized archives in Mughal India.
Religious Differences and Imperial Pragmatism in a Polemical Arena: A Privileged Law for Muslims, Hindus, and Jains in Diu (1557)
Authors: Paiva José Pedro 
Published: February 2024

Abstract
In 1557 Francisco Barreto, the Portuguese governor of the State of India, issued a decree forbidding the destruction of temples and books belonging to the Gujarati Muslims, Hindus, and Jains of Diu and allowed them to practice their religion freely. This and other reforms introduced by the crown and the Goan archbishop created a special situation for Muslims and Hindus living in Diu, in contrast to the policies designed to establish monolithic confessionalism that the Portuguese authorities had been attempting to impose in most part of Asia since around 1540.
This article aims to reconstruct and explain the specific nature of the religious policies pursued in Diu, adopting a holistic approach that compares them with developments in other areas of Portuguese Asia. It will be argued that the policies adopted made Diu a multiconfessional city, one that accommodated interreligious encounters though it was less supportive of mobility between different religions. This was the outcome of pragmatism, an essential feature of the actions of the different Portuguese agents who intervened at different levels, creating dynamics in which the role of the native population was also decisive in shaping imperial societies.
Locating the Littoral: Michael N. Pearson in the Study of the Northern Bay of Bengal
Authors: Bhattacharyya Shatarupa 
Published: February 2024

Abstract
This article takes up Michael Pearson’s concept of littoral societies and discusses how it provides us with a lens to study a specific estuarine place, a mangrove forest called Sundarbans that is found along the coastlines of India and Bangladesh and opens onto the Bay of Bengal. Inhabitants cope with constant risks and hazards, maintaining distinctive folk traditions practiced by both the region’s Hindus and Muslims. This article discusses the outsider and insider perceptions of this place and its distinctive material culture, which may provide a window for studying other littoral cultures across the Indian Ocean basin.
Neoplatonic Nature of Love
Authors: Chordá Frederic 
Published: February 2024

Abstract
This essay has two sections. The first explores the origin of the universe, the four elements, the knot of love, the third essence, and ‘Primordial Vessel’ by the Florentine Neoplatonic philosopher Marsilio Ficino. The second part interprets Botticelli’s The Birth of Venus of 1485–1486, now at the Galleria degli Uffizi in Florence, drawing upon Ficino’s Neoplatonic texts. Particularly some of Ficino’s Commentaries on Plato’s Dialogues (published in 1484), Symposium (completed in 1469), Philebus (completed in 1469), and Compendium on Timaeus (1480–1491). To this is added Ficino’s Theologia Platonica (published in 1482), his Letters (published in 1495), his Commentary on Proclus’s Alcibiades I (completed in 1488), and his translation of the Neoplatonic text Corpus Hermeticum, entitled Liber Mercurii Trismegisti de potestate et sapientia Dei (published in 1471). Botticelli’s beautiful painting captures the depiction of the goddess Venus’s birth as described in Hesiod’s Theogony, which Ficino recounted in his Philebus Commentary
The difficult PICC insertion is associated with the significant increase of complications in 1 month follow-up
Authors: Lisova Katerina , Pavelkova Katerina , Matejckova Tereza , Simkova Petra , Hloch Ondrej , Charvat Jiri 
Published: February 2024

Background: PICC is routinely inserted with assistance of ultrasonography and/or ECG navigation (RI- routine insertion). Only in a minority of patients the insertion of a PICC is difficult and fluoroscopic visualization with introduction of special guidewire is necessary for the success of the procedure (DI-difficult insertion). The aim of the study was to evaluate whether DI can be predicted and associated with a risk of complications during follow-up. Methods: The study included patients who had a PICC insertion in 2022. The number of patients with RI and DI was recorded and the significance of selected parameters during insertion and the frequency of complications during 1 month follow-up was compared. Results: About 1404 patients had successful PICC insertion in 2022, RI in 1360 (96.8%) and DI in 44 patients (3.2%). There was no significant effect of age, gender, selected vein, its size, insertion site, and tunneling on the course of PICC insertion. However the number of punctures for needle insertion was higher in DI. The complication rate during 1 month follow-up in DI was 9 (20.4%) versus 101 patients (7.4%) in RI ( p = 0.002). Conclusion: PICC insertion was successful in both RI and DI patients. Of the analyzed parameters, the number of needle punctures was associated with DI, and complications during the 1-month follow-up were more frequently noted in the DI group.