bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol
Authors: Zhu Youzhuang , Feng Wei , Kong Qinghan , Sheng Fang , Li Zhichao , Xu Weilong , Li Qun , Han Yan , Wu Xiuyun , Jia Changxin , Guo Jie , Zhao Yang 
Published: November 2023

IntroductionPostoperative delirium (POD) is an acute, transient brain disorder associated with decreased postoperative quality of life, dementia, neurocognitive changes, and mortality. A small number of trials have explored the role of S-ketamine in the treatment of POD due to its neuroprotective effects. Surprisingly, these trials have failed to yield supportive results. However, heterogeneity in delirium assessment methodologies, sample sizes, and outcome settings as well as deficiencies in S-ketamine use methods make the evidence provided by these studies less persuasive. Given the severe impact of POD on the health of elderly patients and the potential for S-ketamine to prevent it, we believe that designing a large sample size, and rigorous randomized controlled trial for further evaluation is necessary.MethodsThis is a single-center, randomized, double-blind, placebo-controlled, pragmatic study. Subjects undergoing total hip or knee arthroplasty will be randomized in a 1:1 ratio to intervention (n = 186) and placebo (n = 186) groups. This trial aims to explore the potential role of S-ketamine in the prevention of POD. Its primary outcome is the incidence of POD within 3 postoperative days. Secondary outcomes include the number of POD episodes, the onset and duration of POD, the severity and subtype of POD, pain scores and opioid consumption, sleep quality, clinical outcomes, and safety outcomes.DiscussionTo our knowledge, this is the first pragmatic study that proposes to use S-ketamine to prevent POD. We reviewed a large body of literature to identify potential preoperative confounding variables that may bias associations between the intervention and primary outcome. We will use advanced statistical methods to correct potential confounding variables, improving the test’s power and external validity of test results. Of note, the patient population included in this trial will undergo intraspinal anesthesia. Although large, multicenter, randomized controlled studies have found no considerable difference in the effects of regional and general anesthesia on POD, patients receiving intraspinal anesthesia have less exposure to at-risk drugs, such as sevoflurane, propofol, and benzodiazepines, than patients receiving general anesthesia. At-risk drugs have been shown to negatively interfere with the neuroprotective effects of S-ketamine, which may be the reason for the failure of a large number of previous studies. There is currently a lack of randomized controlled studies evaluating S-ketamine for POD prevention, and our trial helps to fill a gap in this area.Trial registration: http://www.chictr.org.cn, identifier ChiCTR2300075796.
Quantifying technical load and physical activity in professional soccer players during pre-season matches with IMU technology
Authors: Losada-Benitez José Augusto , Nuñez-Sánchez Francisco Javier , Barbero-Álvarez José Carlos 
Published: November 2023

This study aimed to record, analyze and quantify professional soccer players’ technical (TL) and physical load (PL) in friendly matches to compare their records during the first and second halves and between players with different positions. Eighteen professional soccer players, 24.6 ± 2.7 years, 1.78 ± 0.3 height (m), 74.6 ± 4.5 body mass (kg), 9.8 ± 2.2 body fat (%), and 65.6 ± 2.7 maximal oxygen consumption (VO2max, ml·kg-1·min-1) were monitored during six preseason friendly matches to analyze the activity profile using technical and physical variables through inertial measurement unit (IMU). No significant differences were found between the periods for the TL and PL. Significant differences were found between specific positions: Full Back (FB: n = 4), Central Defender (CD: n = 3), Midfielder (MD: n = 4), Winger (WG: n = 4), and Forward (FW: n = 3), both the TL and PL. We conclude that the PL profile based on his playing position is independent of the development of the PL shown during friendly matches. The monitoring, quantifying, and controlling of the TL added to the PL provides a more holistic vision of soccer players in friendly matches. The relative ease IMU application technology offers an alternative with less time-cost and more significant benefits than other types of technologies applied up to now.
Learning motivation and environmental support: how first-generation college students achieve success?
Authors: Li Xiaojing , Liu Weitong , Hu Ke 
Published: November 2023

IntroductionWith the continuous expansion of higher education worldwide, the academic performance of first-generation college students has become an essential topic in the scope of international educational research. This study examines the impact of learning motivation (i.e., intrinsic and extrinsic motivation) and environmental support (i.e., instructional, relational, and campus support) on the academic outcomes of first-generation college students based on the Cultural Mismatch Theory and Self-Determination Theory from both individual and environmental perspectives.MethodsA two-stage stratified sampling strategy was adopted to guarantee that the samples were representative of the national populations of college students in mainland China. 87418 data were collected from the China College Student Survey (CCSS) 2020, among which 58,864 were first-generation college students. This study primarily employed descriptive statistical analysis and regression analysis methods.ResultsData analysis revealed that intrinsic learning motivation, relational support, campus support, and academic performance of first-generation college students are significantly lower than those of non-first-generation students. However, this study found no significant differences concerning external learning motivation and teaching support. Regression analysis showed that both learning motivation and environmental support positively predicted learning outcomes, with intrinsic learning motivation having the most substantial influence. Moreover, learning motivation and environmental support interact in jointly promoting the student’s academic success.DiscussionThis study highlighted that the academic development of first-generation college students results from the interplay between individual characteristics and the surrounding environment. Postnatal factors, particularly individual learning motivation, and institutional environment support, play a crucial role in their academic achievements.
Art therapy in Alzheimer’s disease. An opportunity of collaboration between intersectoral public and private organizations in the co-design of health and social care services
Authors: Giusti Martina , Persiani Niccolò 
Published: November 2023

IntroductionThe World Health Organization (WHO) has recognized art therapy as an effective supportive mechanism for the maintenance and restoration of mental health. In recent years, art therapy has been integrated in the assistance pathways of older people affected by neurocognitive disorders according to the demonstrated benefits, as no conflicts with pharmacologic treatments and the reduction of anxiety and stress. The shortage of organizational, economic, and professional resources in social-health public organizations does not allow for guaranteeing the provision of these services without the help of the private ones, not exclusively belonging to social-health sector. This research aims to investigate how the collaboration between public and private organizations of different sectors in the co-provision of non-pharmacological approaches guarantees the economic sustainability and the quality improvement of the provided services.MethodsThe Alzheimer Café of Prato was selected as a significant case study.Results and DiscussionArt therapy programs intended for taking care of older people in the first stages of the Alzheimer’s disease have been developed, planned, supplied, and managed over the years as a result of the integration of resources, ideas, and professionals provided both by public and private sectors, the social-health sector, and cultural organizations.ConclusionsThe peer-to-peer co-responsibility of all organizations (public and private, from the cultural sector as well as the social and health sector) involved in the co-design of art therapy programs, not limiting their actions to only co-financing and/or co-delivery of the service, enabled the achievement of the economic sustainability of the services and the improvement of their quality.
I don’t understand how I feel: mediating role of impaired self-mentalizing in the relationship between childhood adversity and psychosis spectrum experiences
Authors: Nonweiler Jacqueline , Torrecilla Pilar , Kwapil Thomas R. , Ballespí Sergi , Barrantes-Vidal Neus 
Published: November 2023

IntroductionChildhood adversity is associated with the severity of multiple dimensions of psychosis, but the mechanisms underpinning the close link between the two constructs is unclear. Mentalization may underlie this relationship, as impaired mentalizing is found in various stages of the psychosis continuum. Nonetheless, the differential roles of self- and other-mentalizing in psychosis are not well understood.MethodsParallel multiple mediation was conducted for the relationship between a diverse range of childhood adversity types, including intentional and nonintentional harm, and schizotypy (positive, negative, disorganized), psychotic-like experiences (PLE) and paranoia via self-mentalizing (attention to emotions and emotional clarity) and other-mentalizing in n = 1,156 nonclinically ascertained young adults.ResultsSignificant parallel multiple mediation models were found for all psychotic outcomes except negative schizotypy. The associations between intentionally harmful childhood adversity and psychotic outcomes were significantly mediated by increased attention to emotions for most models and decreased emotional clarity for some models. No significant mediation was found for parental loss. Paternal abuse was only mediated by attention to emotions whereas the effects of maternal abuse were mediated by attention to emotions and emotional clarity. Other-mentalizing only showed mediating effects on one of thirty models tested.ConclusionResults highlight the mediating role of impaired self-mentalizing in the association between childhood adversity and psychosis. This is consistent with disturbances of self-concept and self-boundary characterizing, in particular, the positive dimension of psychosis. Maternal versus paternal figures may contribute differentially to the development of mentalizing. These results could inform future preventative interventions, focusing on the development and maintenance of self-mentalizing.
Could reasons for admission help to screen unhealthy alcohol use in emergency departments? A multicenter French study
Authors: Chabert Jonathan , Lambert Céline , Cabé Julien , Cherpitel Cheryl J. , Rolland Benjamin , Moustafa Farès , Lesage Patrick , Ragonnet Delphine , Geneste Julie , Poulet Emmanuel , Dematteis Maurice , Naassila Mickael , Chalmeton Maryline , Llorca Pierre-Michel , Pereira Bruno , De Chazeron Ingrid , Brousse Georges 
Published: November 2023

BackgroundMany patients admitted to general emergency departments (EDs) have a pattern of drinking that could lead to future alcohol-related complications. However, it is often difficult to screen these patients in the context of emergency. The aim of this study is to analyze whether reasons for admission could help to screen patients who have an unhealthy alcohol use.MethodPatients were recruited among six public hospital ED in France, between 2012 and 2014. During a one-month period in each hospital, anonymous questionnaires including sociodemographic questions, AUDIT-C and RAPS4-QF were administered to each patients visiting the ED. The reason for admission of each patient was noted at the end of their questionnaire by the ED practitioner.ResultsTen thousand Four hundred twenty-one patients were included in the analysis. Patients who came to the ED for injuries and mental disorders were more likely to report unhealthy alcohol use than non-harmful use or no use. Among male patients under 65 years old admitted to the ED for a mental disorder, 24.2% drank more than four drinks (40 g ethanol) in typical day at least four time a week in the last 12 months. Among these patients, 79.7% reported daily or almost daily heavy episodic drinking (HED, 60 g ethanol), and all were positive on the RAPS4-QF.ConclusionThis study highlights that unhealthy alcohol use is frequent among ED patients and particularly among those who come for injuries or mental disorders. Men under 65 years old with a mental disorder require special attention because of their increased prevalence of daily or almost daily HED.
The causal configurations of provincial health policy innovation in China: an analysis of the food safety standard filing policy
Authors: Li Li , Han Guanghua , Chen Yanting , Zhang Zilin , Fu Xiao 
Published: November 2023

IntroductionAccording to China’s Food Safety Law of 2015, the filing of food safety enterprise standards is a policy innovation led by p9rovincial governments in China. However, there are significant differences in the development of the “Food Safety Enterprise Standard Filing Policy” between provincial governments across the country. This study aims to explore the internal mechanisms driving autonomous innovation by provincial governments in the absence of administrative pressure from the central government, to better understand the policy innovation mechanism in the Chinese context.MethodsCrispy Set Qualitative Comparative Analysis (csQCA) method is used to identify the innovation mechanism.ResultsThis study found that provinces with good provincial economic resources and strong government capabilities are prone to policy innovation, and the influence of internal factors of provincial governments is stronger than that of external factors.DiscussionWhen provincial economic resources and capacity are weak, endogenous factors in the province also help achieve proactive policy innovation by provincial governments. The research results reveal how provincial governments construct local policies in the absence of administrative pressure from the central government.
Work-family trajectories across Europe: differences between social groups and welfare regimes
Authors: Firat Mustafa , Visser Mark , Kraaykamp Gerbert 
Published: November 2023

IntroductionWork and family trajectories develop and interact over the life course in complex ways. Previous studies drew a fragmented picture of these trajectories and had limited scope. We provide the most comprehensive study of early-to-midlife work-family trajectories to date.MethodsUsing retrospective data from waves 3 and 7 of the Survey of Health, Aging and Retirement in Europe (SHARE), we reconstructed work-family trajectories from age 15 to 49 among almost 80,000 individuals born between 1908 and 1967 across 28 countries. We applied multichannel sequence and cluster analysis to identify typical trajectories and multinomial logistic regression models to uncover their social composition.ResultsThe results revealed six common trajectories. The dominant and therefore standard trajectory represents continuous full-time employment with having a partner and children. Women, the lower educated and persons from conservative and liberal welfare regimes are underrepresented in this trajectory, whereas men, higher educated people and those from social-democratic, Eastern European and Baltic welfare regimes are overrepresented. The other trajectories denote a deviation from the standard one, integrating a non-standard form of work with standard family formation or vice versa. Mothers in a stable relationship generally work part-time or not at all. When mostly in full-time employment, women are more likely to be divorced. Lower educated persons are less likely to have work-family trajectories characterized by full-time work and a non-standard family, yet more likely to be non-employed for large parts of their life with standard family formation. Younger cohorts are underrepresented in non-employment trajectories, but overrepresented in part-time employment trajectories along with a partner and children as well as full-time employment trajectories with divorce. Individuals from Southern European and liberal regimes are more likely to be non-working and self-employed partnered parents and those from social-democratic regimes are more likely to be full-time employed divorced parents. We also found pronounced gender differences in how educational level, birth cohort and welfare regime are associated with work-family trajectories from early to midlife.DiscussionOur findings highlight the socially stratified nature of earlier-life work-family trajectories in Europe. Potential implications for inequalities in later life are discussed.
Hong Kong veterinarians’ encounters with client-related stress – a qualitative study
Authors: Chan Camille K. Y. , Wong Paul W. C. 
Published: November 2023

AimsLimited research has explored the stressors experienced by veterinarians in East Asia. Metropolitan cities like Hong Kong may have overlooked factors that significantly contribute to veterinarians’ stress. This paper examines how client-related stressors and contextual factors contribute to the stress levels of Hong Kong-based veterinarians.MethodsVeterinarians from small domestic animal practices in Hong Kong were recruited using purposive and targeted snowball samplings until thematic saturation was achieved. Semi-structured in-depth interviews were conducted, audio-recorded, transcribed, coded, and analysed using reflexive thematic analysis with an interpretivist paradigm based on Heidegger’s phenomenological approach.ResultsA total of 18 participating veterinarians described the expectations of and communication with the animal-health enthusiast (AHE) community, including clients, pet owners, and animal lovers, as their primary source of stress. Discrepant expectations and miscommunication between the AHE and veterinary communities, along with contextual factors, such as convenience in clinic switching, negative online reviews, and the relatively short history of the veterinary profession in the multilingual city, were identified as contributing factors to their stress. Recent socio-political events and the pandemic further intensified societal emotions, leading some clients to project frustrations onto perceived authority figures, including health professionals.ConclusionThe study highlights that client-related stress extends beyond the health of animal patients, encompassing the expectations of the AHE community, which requires professional-level communication skills to build a mutually respectful three-party relationship. Besides, Hong Kong’s unique contextual and historical factors subtly but chronically impact veterinary practices, which can be easily overlooked. Recognising these influences and how they interact is crucial for collaboration, within and beyond the profession, at the policy level to improve veterinary training and practices.ImplicationsOur findings highlight the importance of expectation management and improving communication quality to foster healthy relationships among animals, the AHE community, and veterinary professionals. These efforts are believed to alleviate veterinarians’ stress and enhance the well-being of all parties involved. We recommend incorporating effective communication and self-care discussions into the veterinary curriculum and advocating ongoing training for practising veterinarians. At the community level, encouraging open dialogues between animal caregivers and veterinary professionals can help address expectation discrepancies.
Acute NO2 Stress Shortens the Median Survival Period of Bougainvillea glabra ‘Elizabeth Angus’ by Disrupting Tissue Structure and Photosynthetic Response Centers
Authors: Liang Yuxiang , Qian Xinchen , Song Shuang , Sheng Qianqian , Zhu Zunling 
Published: November 2023

The air pollutant NO2 is one of the major constraints on plant growth, and the ecological value of the ornamental plant Bougainvillea glabra can be weakened by NO2. In this study, an indoor 4 μL·L−1 NO2 simulated fumigation test was conducted with three treatments, CK (normal growth with clean air), T1 (4 μL·L−1 NO2 + 8 h/d), and T2 (4 μL·L−1 NO2 + 24 h/d), which were set up with considerations for time and concentration. The results demonstrated that most of the morphological parameters of B. glabra ‘Elizabeth Angus’, except for the floral organs, were decreased in the root, stem, leaf, and bract. Continuous fumigation significantly attenuated the growth rate and reduced the water and pigment contents of organs. Excessive NO2 reduced the number and transfer rate of photoelectrons by destroying the photosynthetic reaction center, which in turn weakened photosynthesis, but the plants with intermittent fumigation recovered after fumigation. The Kaplan-Meier (K-M) survival curve displayed median survival periods of 41 and 55.5 h for T1 and T2, respectively, and the morphological structure and most of the indicators of photosynthetic reaction centers changed significantly during stress. Acute injury to B. glabra ‘Elizabeth Angus’ was caused by 4 μL·L−1 NO2, and B. glabra ‘Elizabeth Angus’ had limited ability to regulate high concentrations of NO2 acute stress.
Compuestos bioactivos y actividad antioxidante de aceites esenciales en hojas de plantas medicinales
Authors: Taipe Pardo Fredy , Huaraca Aparco Rosa , Merino Quispe Isaac , Flores Pacheco Niki Franklin , Agreda Cerna Henrry Wilfredo , Quispe Chipana Salvador 
Published: November 2023

Los antioxidantes naturales han suscitado un interés creciente para su uso en la industria alimentaria. Objetivo. La investigación tuvo como objetivo determinar los componentes bioactivos y actividad antioxidante del aceite esencial de matico (Piper aduncum) y la borraja (Borago officinalis). Materiales y Métodos. El aceite esencial se obtuvo mediante destilación a vapor, se logró determinar el rendimiento de extracción, densidad relativa, índice de éster, índice de refracción y el porcentaje de solubilidad en solución de etanol. Los componentes bioactivos se determinaron a través de la cromatografía de masa (GC-MS), finalmente se determinó la actividad antioxidante mediante el método de radicales libres 2,2-difenil-1-picryhydraci (DPPH). Resultados. Los rendimientos de extracción variaron de 0,29 a 0,43%, con una tasa de extracción positiva de 0,0367 %/ psi, densidad alrededor de 0,996 (g/ml) con resultados similares para presiones de extracción de 8 y 10 psi en ambas especies, con un índice de refracción de 1,52 para el aceite esencial y 1,33 hidrolatos y un aumento de la acidez con presión de extracción de 2,69 a 5,46 mg KOH/g. La capacidad antioxidante en las dos muestras fueron diferentes entre 14,258 a 017.030 ?mol TEAC/ml mostrando una diferencia con la presión de extracción. En los aceites esenciales de la especie Piper. aduncum fue posible identificar 24 componentes químicos a para Borago officinalis, ambas especies presentadas como componentes principales para apiol en las tres presiones de extracción de un total de (14%). Conclusiones. Son una fuente componentes bioactivos que promueven las potencialidades antimicrobianas y antioxidantes para su uso como conservantes de alimentos.