bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the association between stigmatizing attitudes in nursing students and their desire for a career in mental health nursing: A comparative analysis of generic and accelerated programs in Israel
Authors: Ben Natan Merav , Gharra Adam , Faduos Baher , Magadlah Abedallah , Biadsy Abedalrahman 
Published: February 2024

Accessible SummaryWhat is known on the subject?

Mental health nursing is generally viewed as the least attractive career choice among nursing students.

What the paper adds to existing knowledge?

Studying in the generic nursing program influence higher desire for a career in mental health nursing.

Nursing students who have prior experience working in mental health and have provided care to psychiatric patients are more inclined to express a desire to pursue a career in this field

What are the implications for practice?

Nursing students enrolled in the generic program, who have previous work experience in mental health or experience caring for a person with a mental illness, and who have a lower level of stigmatizing attitudes, may constitute the future workforce in mental health nursing.

AbstractIntroductionMental health nursing is often perceived as an unattractive career choice among nursing students, and it remains unclear whether the type of nursing program influences this view.AimThis cross‐sectional study aimed to explore the association between stigmatizing attitudes in nursing students and their desire for a career in mental health nursing, comparing students in generic and accelerated programs.MethodA total of 220 nursing students from generic and accelerated programs in North‐Center Israel participated in this cross‐sectional study, completing a questionnaire on stigmatizing attitudes and their interest in a mental health nursing career.ResultsNursing students displayed a generally low desire for mental health nursing, influenced by factors such as enrollment in the generic program, previous mental health work experience and stigmatizing attitudes.DiscussionStudents in the generic program, with lower stigmatizing attitudes and prior mental health experience, exhibited a higher inclination towards mental health nursing.Implications for PracticeProspective mental health nursing professionals may be identified in the generic program, particularly those with prior mental health experience and lower stigmatizing attitudes. Additional studies are required to confirm and broaden their applicability to other contexts.
Psychological first aid practice self‐efficacy of nurses in disasters
Authors: Kiliç Bayageldi Nurhayat , Kaloğlu Binici Dilek 
Published: February 2024

AbstractIn the present cross‐sectional study, we determined the self‐efficacy of nurses to apply psychological first aid (PFA) during disasters. The study sample consisted of 580 nurses working in Turkey. The data were collected online between July and November 2022 using the “Personal Information Form” and the “PFA Application Self‐Efficacy Scale.” The data were analyzed using descriptive statistical methods (number, percentage, mean, and standard deviation), generalized linear models, Bonferroni correction, and linear regression analysis. The mean PFA scale scores of male nurses, nurses working in intensive care units, working as service nurses, nurses who have previously received PFA training and applied PFA in disaster situations were higher. Moreover, 91.3% of nurses did not receive PFA training and 90.3% did not receive PFA service earlier, 31.0% did not apply for PFA, 18.3% did not know about PFA. The mean score of the PFA practice self‐efficacy scale of nurses was 131.61 ± 19.41. There exists an urgent requirement to develop nurses' PFA application self‐efficacy. It is recommended that nurses should be provided repeated PFA training and applied studies focusing on PFA interventions.
PopulusMYC2 orchestrates root transcriptional reprogramming of defence pathway to impair Laccaria bicolor ectomycorrhizal development
Authors: Marqués‐Gálvez José Eduardo , Pandharikar Gaurav , Basso Veronica , Kohler Annegret , Lackus Nathalie D. , Barry Kerrie , Keymanesh Keykhosrow , Johnson Jenifer , Singan Vasanth , Grigoriev Igor V. , Vilgalys Rytas , Martin Francis , Veneault‐Fourrey Claire 
Published: February 2024

Summary
The jasmonic acid (JA) signalling pathway plays an important role in the establishment of the ectomycorrhizal symbiosis. The Laccaria bicolor effector MiSSP7 stabilizes JA corepressor JAZ6, thereby inhibiting the activity of Populus MYC2 transcription factors. Although the role of MYC2 in orchestrating plant defences against pathogens is well established, its exact contribution to ECM symbiosis remains unclear. This information is crucial for understanding the balance between plant immunity and symbiotic relationships.
Transgenic poplars overexpressing or silencing for the two paralogues of MYC2 transcription factor (MYC2s) were produced, and their ability to establish ectomycorrhiza was assessed. Transcriptomics and DNA affinity purification sequencing were performed.
MYC2s overexpression led to a decrease in fungal colonization, whereas its silencing increased it. The enrichment of terpene synthase genes in the MYC2‐regulated gene set suggests a complex interplay between the host monoterpenes and fungal growth. Several root monoterpenes have been identified as inhibitors of fungal growth and ECM symbiosis.
Our results highlight the significance of poplar MYC2s and terpenes in mutualistic symbiosis by controlling root fungal colonization. We identified poplar genes which direct or indirect control by MYC2 is required for ECM establishment. These findings deepen our understanding of the molecular mechanisms underlying ECM symbiosis.
APP1/NTL9‐CalS8 module ensures proper phloem differentiation by stabilizing callose accumulation and symplastic communication
Authors: Liu Jie , Fan Yongxiao , Liu Yao , He Meiqing , Sun Yanke , Zheng Qi , Mi Lingyu , Liu Junzhong , Liu Wencheng , Tang Ning , Zhao Xiang , Hu Zhubing , Guo Siyi , Yan Dawei 
Published: February 2024

Summary
Phloem sieve elements (PSE), the primary conduits collaborating with neighboring phloem pole pericycle (PPP) cells to facilitate unloading in Arabidopsis roots, undergo a series of developmental stages before achieving maturation and functionality. However, the mechanism that maintains the proper progression of these differentiation stages remains largely unknown.
We identified a gain‐of‐function mutant altered phloem pole pericycle 1 Dominant (app1D), producing a truncated, nuclear‐localized active form of NAC with Transmembrane Motif 1‐like (NTL9). This mutation leads to ectopic expression of its downstream target CALLOSE SYNTHASE 8 (CalS8), thereby inducing callose accumulation, impeding SE differentiation, impairing phloem transport, and inhibiting root growth.
The app1D phenotype could be reproduced by blocking the symplastic channels of cells within APP1 expression domain in wild‐type (WT) roots. The WT APP1 is primarily membrane‐tethered and dormant in the root meristem cells but entries into the nucleus in several cells in PPP near the unloading region, and this import is inhibited by blocking the symplastic intercellular transport in differentiating SE.
Our results suggest a potential maintenance mechanism involving an APP1‐CalS8 module, which induces CalS8 expression and modulates symplastic communication, and the proper activation of this module is crucial for the successful differentiation of SE in the Arabidopsis root.
Linagliptin's impact on lymphatic barrier and lymphangiogenesis in oral cancer with high glucose
Authors: Wang Hongyu , She Xiao , Xu Qiongdong , Zhou Xingyu , Tang Qinchao , Wei Huakun , Huang Tianjing , Liang Feixin 
Published: February 2024

AbstractObjectivesUncertainties remain regarding the effect of elevated glucose levels on lymphatic metastasis of cancer cells. Our study elucidated the mechanisms linking high glucose to lymphangiogenesis and lymphatic barrier‐related factors and investigated the protective role of linagliptin against lymphatic barrier dysfunction.Materials and MethodsA CAL‐27‐LEC co‐culture system was established. Sodium fluorescein permeability assay observed lymphatic endothelial cell permeability. Western blotting and RT‐qPCR detected protein and mRNA expression under different conditions, respectively. CCK‐8, scratch wound healing, and transwell assays revealed cell migration and proliferation. Tube formation experiment tested capacity for endothelial tube formation. Immunohistochemical staining analyzed tissue sections from 43 oral cancer individuals with/without diabetes.ResultsIn high‐glucose co‐culture system, we observed increased lymphatic barrier permeability and decreased expression of ZO‐1 and occludin, two tight‐junction proteins; conversely, the expression of PAR2, a high permeability‐related protein, was increased. Following linagliptin treatment, the expression levels of VEGF‐C, VEGFR‐3, and PAR2 decreased, while those of ZO‐1 and occludin increased. Considerably higher levels of LYVE‐1 expression in individuals with diabetes than in those without diabetes.ConclusionsBy ameliorating the high glucose‐induced disruption of the lymphatic endothelial barrier, linagliptin may reduce lymphangiogenesis and exhibit an inhibitory effect on lymphatic metastasis in oral cancer patients with diabetes.
Application of metabolomics in oral squamous cell carcinoma
Authors: Luo Guanfa , Wang Shuai , Lu Wen , Ju Wei , Li Jianhong , Tan Xiao , Zhao Huiting , Han Wei , Yang Xihu 
Published: February 2024

AbstractBackgroundOral squamous cell carcinoma (OSCC) is a prevalent malignancy affecting the head and neck region. The prognosis for OSCC patients remains unfavorable due to the absence of precise and efficient early diagnostic techniques. Metabolomics offers a promising approach for identifying distinct metabolites, thereby facilitating early detection and treatment of OSCC.ObjectiveThis review aims to provide a comprehensive overview of recent advancements in metabolic marker identification for early OSCC diagnosis. Additionally, the clinical significance and potential applications of metabolic markers for the management of OSCC are discussed.ResultsThis review summarizes metabolic changes during the occurrence and development of oral squamous cell carcinoma and reviews prospects for the clinical application of characteristic, differential metabolites in saliva, serum, and OSCC tissue. In this review, the application of metabolomic technology in OSCC research was summarized, and future research directions were proposed.ConclusionMetabolomics, detection technology that is the closest to phenotype, can efficiently identify differential metabolites. Combined with statistical data analyses and artificial intelligence technology, it can rapidly screen characteristic biomarkers for early diagnosis, treatment, and prognosis evaluations.
USP14 promotes the cancer stem‐like cell properties of OSCC via promoting SOX2 deubiquitination
Authors: Liu Chang , Zhou Shijie , Tang Wei 
Published: February 2024

AbstractObjectiveUSP14 (Ubiquitin‐specific‐processing protease 14) is a deubiquitinating enzyme with oncogenic effects in oral squamous cell carcinoma (OSCC). This study aims to identify new substrates of USP14 and elucidate their role in modulating cancer stem‐like cells (CSCs) in OSCC.Materials and MethodsBioinformatics prediction and docking were performed using UbiBrowser 2.0 and HDOCK, respectively. OSCC cell lines and patient‐derived cells were used for experimental validation, employing co‐immunoprecipitation, cycloheximide chase assays, and tumor sphere formation to evaluate the effects of USP14 on SOX2 stability, ubiquitination, and CSC phenotypes.ResultsUSP14 upregulation was associated with worse overall survival and progression‐free interval in OSCC. USP14 interacted with SOX2 with its ubiquitin carboxyl‐terminal hydrolase domain. USP14 knockdown impaired SOX2 stability by increasing its polyubiquitination. Ectopic overexpression of wild‐type USP14, but not the hydrolase‐deficient‐mutant USP14C114A, enhanced SOX2 stability by reducing polyubiquitination. USP14 knockdown suppressed OSCC cell proliferation, colony formation, and tumor sphere formation in vitro and tumor growth in vivo. However, the reduction of CSC markers following USP14 knockdown was mitigated by overexpressing SOX2. These findings were verified in OSCC patient‐derived CSC cells.ConclusionThis study revealed a USP14‐SOX2 axis regulating the CSC properties of OSCC.
‘A random assembly of geometric forms’: Thing Theory in J. G. Ballard's and Ray Bradbury's short stories
Authors: Tereszewski Marcin 
Published: February 2024

AbstractThing Theory is a relatively new field of research, developed largely by Bill Brown on the basis of an already existing new materialist movement with roots reaching back to Martin Heidegger's interrogation of the ontology of things in ‘Das Ding’. Focusing on the interconnectedness of objects, their modes of being and irreducible ‘thingness’, as well as the agency objects are shown to exert when freed from the constraints of a subject‐centred perspective, this article presents a reading of three short stories by J. G. Ballard and Ray Bradbury which showcase how such issues are navigated in narrative form. Of particular interest for this article is the subject–object relationship, and the notion of ‘thingness’ as developed in Thing Theory in relation to the unique role accorded to the environment and inanimate objects in J. G. Ballard's and Ray Bradbury's selected works of fiction. It will be shown that a common theme connecting these works is the presence of a confrontation with the external world as it exists outside the definitions imposed on it by human subjects.
Myoglobin deficiency impairs maximal oxygen uptake and exercise performance: a lesson from Mb−/− mice
Authors: Zoladz Jerzy A. , Grandys Marcin , Smeda Marta , Kij Agnieszka , Kurpinska Anna , Kwiatkowski Grzegorz , Karasinski Janusz , Hendgen‐Cotta Ulrike , Chlopicki Stefan , Majerczak Joanna 
Published: February 2024

AbstractMyoglobin (Mb) plays an important role at rest and during exercise as a reservoir of oxygen and has been suggested to regulate NO• bioavailability under hypoxic/acidic conditions. However, its ultimate role during exercise is still a subject of debate. We aimed to study the effect of Mb deficiency on maximal oxygen uptake () and exercise performance in myoglobin knockout mice (Mb−/−) when compared to control mice (Mb+/+). Furthermore, we also studied NO• bioavailability, assessed as nitrite (NO2−) and nitrate (NO3−) in the heart, locomotory muscle and in plasma, at rest and during exercise at exhaustion both in Mb−/− and in Mb+/+ mice. The mice performed maximal running incremental exercise on a treadmill with whole‐body gas exchange measurements. The Mb−/− mice had lower body mass, heart and hind limb muscle mass (P < 0.001). Mb−/− mice had significantly reduced maximal running performance (P < 0.001). expressed in ml min−1 in Mb−/− mice was 37% lower than in Mb+/+ mice (P < 0.001) and 13% lower when expressed in ml min−1 kg body mass−1 (P = 0.001). Additionally, Mb−/− mice had significantly lower plasma, heart and locomotory muscle NO2− levels at rest. During exercise NO2− increased significantly in the heart and locomotory muscles of Mb−/− and Mb+/+ mice, whereas no significant changes in NO2− were found in plasma. Our study showed that, contrary to recent suggestions, Mb deficiency significantly impairs and maximal running performance in mice.
imageKey points
Myoglobin knockout mice (Mb−/−) possess lower maximal oxygen uptake () and poorer maximal running performance than control mice (Mb+/+).
Respiratory exchange ratio values at high running velocities in Mb−/− mice are higher than in control mice suggesting a shift in substrate utilization towards glucose metabolism in Mb−/− mice at the same running velocities.
Lack of myoglobin lowers basal systemic and muscle NO• bioavailability, but does not affect exercise‐induced NO2− changes in plasma, heart and locomotory muscles.
The present study demonstrates that myoglobin is of vital importance for and maximal running performance as well as explains why previous studies have failed to prove such a role of myoglobin when using the Mb−/− mouse model.
Characterizing Drop-Wall Interactions of Engine Fuels at Engine-Relevant Conditions Using Smoothed Particle Hydrodynamics
Authors: Patwary Mohammad F. F. , Isik Doruk , Kong Song-Charng , Mayhew Eric , Kim Kenneth S. , Kweon Chol-Bum M. 
Published: February 2024

Abstract
In an internal combustion engine, interactions of fuel droplets and heated walls can significantly affect the combustion process and engine performance. The formation and characteristics of secondary droplets from drop-wall interactions are functions of various factors such as fuel properties, impact velocity, ambient conditions, and wall temperature. Understanding the impact behavior is important to optimize the distribution of the fuel-air mixture for efficient and clean combustion and to develop a comprehensive spray-wall interaction model. In this study, three-dimensional smoothed particle hydrodynamics (SPH) simulations are performed to investigate the interactions of fuel droplets with a heated wall at atmospheric and elevated pressures over a range of Weber numbers (We). The SPH model is validated using available experimental data. Secondary atomization is characterized by using size distributions for different fuels. The resulting droplets vary in size, where secondary droplets are mostly below 7 μm in diameter. Following these cases, this paper qualitatively describes the impact process and proposes empirical correlation relating the mean secondary droplet size to ambient pressure in the film-boiling regime. Postimpingement vaporization characteristics are also analyzed and compared for fuels with drastically different vapor pressures.
Experimental Study of the Impact of Ethanol Content on Partially Premixed Combustion With Ethanol-Gasoline Blends
Authors: Gainey Brian , Gandolfo John , Lawler Benjamin 
Published: February 2024

Abstract
As ethanol production increases and the demand for gasoline in spark ignition engines decreases over the next few decades, the use of these fuels in compression ignition systems is expected to increase. This raises the question of how much ethanol-in-gasoline is the right blend for compression ignition. This work experimentally studied E10, E30, E50, E75, and E100 in a split injection partially premixed compression ignition strategy. It was found that, separately, the cool flame reactivity of E10 and the high cooling potential of E75 and E100 enable heat release rate control in partially premixed combustion. E30 and E50 did not show the same control authority. E30 performed the worst due to having a small amount of cool flame reactivity and a low cooling potential. It was found that NOx emissions were not significantly impacted by ethanol content, but the smoke emissions were. E100 produced near zero smoke, but all the ethanol-gasoline blends produced some smoke. When 20% of the fuel was injected during the mid-dle of the compression stroke, E10, E30, E50, and E75 all produced low, but nonzero smoke emissions. When the second injection was moved near top dead center, the smoke emissions of E75 stayed low but the smoke emissions of E10, E30, and E50 all rose to a filter smoke number greater than 0.3. These results indicate that low- and high-ethanol content gasolines are both viable paths forward for partially premixed combustion systems, but medium-ethanol content gasolines should be avoided.
The KID Study (Kids Interacting With Dogs): Piloting a Novel Approach for Measuring Dog-Facilitated Youth Physical Activity
Authors: Chase Colleen J. , Burkart Sarah , Potter Katie 
Published: February 2024

Background: Two-thirds of children in the United States do not meet the National Physical Activity Guidelines, leaving a majority at higher risk for negative health outcomes. Novel, effective children’s physical activity (PA) interventions are urgently needed. Dog-facilitated PA (e.g., dog walking and active play) is a promising intervention target, as dogs support many of the known correlates of children’s PA. There is a need for accurate methods of quantifying dog-facilitated PA. Purpose: The study purpose was to determine the feasibility and acceptability of a novel method for quantifying the volume and intensity of dog-facilitated PA among dog-owning children. Methods: Children and their dog(s) wore ActiGraph accelerometers with a Bluetooth proximity feature for 7 days. Additionally, parents logged child PA with the family dog(s). Total minutes of dog-facilitated PA and percentage of overall daily moderate to vigorous PA performed with the dog were calculated. Results: Twelve children (mean age = 7.8 ± 2.9 years) participated. There was high feasibility, with 100% retention, valid device data (at least 4 days ≥6-hr wear time), and completion of daily parent log and questionnaire packets. On average, dog-facilitated PA contributed 22.9% (9.2 min) and 15.1% (7.3 min) of the overall daily moderate to vigorous PA for children according to Bluetooth proximity data and parent report, respectively. Conclusions: This pilot study demonstrated the feasibility of utilizing an accelerometer with a proximity feature to quantify dog-facilitated PA. Future research should use this protocol with a larger, more diverse sample to determine whether dog-facilitated PA contributes a clinically significant amount toward overall PA in dog-owning youth.
Common Wrist-Extensor Tendon and Pectoralis Muscle Stiffness in Healthy Recreational Tennis Players
Authors: Day Joseph M. , Merriman Harold 
Published: February 2024

Context: Imbalances in upper-extremity soft tissue stiffness may play a role in the development of shoulder and elbow musculoskeletal injuries in tennis players. Ultrasound shear wave elastography provides quantifiable and specific data regarding muscle stiffness. The purpose of this study was to compare tendon and muscle stiffness in healthy tennis players to nontennis players. Design: Cross-sectional study. Methods: The shear wave modulus, measured in kilopascals, was obtained for the dominant pectoralis major, pectoralis minor, and common wrist-extensor tendon using 2-dimensional shear wave elastography ultrasound imaging (GE Logiq S8, L9 linear transducer). Independent t test was run to compare age, body mass index, and the activity index score between both groups. Within-day intrarater reliability was assessed using a within-examiner intraclass correlation coefficients (ICC [3, 1]) with 95% confidence intervals. A multivariate general linear model was run to compare the mean differences between the tennis and nontennis players for each of the soft tissues. Results: Twenty-six individuals (13 tennis players and 13 nontennis players) were recruited. Within-day ICCs were very good (ICC > .78 for the pectoralis musculature) and excellent (ICC > .94 for the common wrist extensor). Common extensor tendon stiffness was significantly higher in tennis players compared to nontennis players (mean difference = 114.8 [61.8], confidence interval, −22.8 to 252.5 kPa for the dominant arm [P = .039]). Mean pectoralis major and minor stiffness differences were not significant (P > .214). Conclusions: Common wrist-extensor stiffness in healthy recreational tennis players is higher than those who do not play tennis. Therefore, clinicians may need to facilitate a greater soft tissue stiffness response with resistance training when rehabilitating recreational tennis players as compared to those not playing tennis. Additional normative data on a larger sample of recreational tennis players should be collected.