bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frailty and long-term survival in patients undergoing cardiac resynchronization therapy
Authors: Soldatova A. M. , Enina T. N. , Malishevskaia D. S. 
Published: January 2024

Aim: To access frailty and its impact on 10-year survival in patients with implanted devices for cardiac resynchronization therapy (CRT).Methods: 77 patients with congestive heart failure (74% men, 26% women; mean age of 58.7 ± 10.7 years) with NYHA class II–IV were enrolled. Frailty Index was calculated using 31 parameters (the ability to perform daily activities, clinical status, laboratory markers, comorbidities). Based on the frailty index patients were identified as not frail (< 0.375; n = 41; 53%), and frail (≥ 0.375; n = 36; 47%).Results: The mean follow-up period was 49.0 ± 34.2 months. Survival at 10-year follow-up was 87.5% for non-frail patients, compared to 47.2% for frail patients (log-rank test p < 0.001). In univariate analysis, frailty associated with 10-year mortality (OR 7.824; 95% CI 2.495 – 24.533; p < 0.001). After adjustment for age, gender, rhythm, NYHA class, left ventricular ejection fraction, left bundle branch block, and QRS width, frailty remained a significant prognostic factor associated with 10-year mortality (OR 9.528; 95% CI 2.720 – 33.368; p < 0.001). Also, according to logistic regression, the presence of frailty reduced the chance of superresponse (decrease of left-ventricular end -systolic volume ≥ 30%) to CRT (OR 0.278; 95% CI 0.100–0.770; p = 0.014).Conclusion: Frailty is widespread in patients with heart failure and implanted devices for CRT. In these patients frailty is associated with a more than seven-fold increased risk of death during 10-year follow-up and with a lower chance of superresponse to CRT.
Environmental Impact Assessment on the Development and Operation of Type B Terminal in Bontang City
Authors: Tukimun Tukimun , Widayanti Diyat Susrini , Trias Wahyu Mahendra , Anugrah Riz , Zaman Kumarul 
Published: January 2024

Purpose: The Type B Terminal is critical for improving the area's connectivity and accessibility, particularly in Bontang City and its surroundings. The principles of equality, ecological balance, resilience, sustainable development, viability, and connectivity will guide the terminal's construction and operation. The effects on environmental components must be evaluated, and appropriate countermeasures must be implemented to ensure the project's long-term viability.
Design/methodology/approach: The impacts and countermeasures of the terminal in Gunung Telihan Village, West Bontang District, Bontang City, East Kalimantan Province were determined using a qualitative descriptive method. The matrix method was used to determine the significant impacts during the pre-construction, construction, and operational stages. The structure and operation are expected to have seven effects on the physical environment components, including a reduction in air quality, an increase in noise intensity, a decrease in surface water quality, a disruption in smooth and safe traffic, damage to existing roads, specific waste handling (unloading), and the generation of domestic solid and liquid waste.
Findings: At the same time, three components must be evaluated when implementing countermeasures: disruption of smooth and safe traffic, generation of domestic solid and liquid waste, and handling of specific waste (building demolition) to mitigate the impacts.
Paper type: Research paper
The EXPLORING THE AFFECTING RELATIONSHIP FACTOR OF JOB PERFORMANCE IN PT. PAMAPERSADA NUSANTARA
Authors: Wardana Kurniawan Pitta , Sugiharto Erfan , Yuansa Futra Kurnia , Syamil Ahmad 
Published: January 2024

Purpose: This research proposes to examine the relationship between job performance and empathic leadership, job satisfaction, and work engagement.
Design/methodology/approach: The quantitative research technique is referred to as the research method. The target of this research is PT. Pamapersada Nusantara, and the research sample, which consists of 386 respondents, refers to the structural equational modelling model.
Findings: The findings demonstrated that the respondents believed that each and every hypothesis had been confirmed.
Research limitations/implications: The study only focused on a specific set of factors that may influence job performance, such as individual crafting, supervisory support, and work engagement. Other factors, such as organisational culture or job demands, were not explored in depth. It is important for future research to investigate these additional factors and their potential impact on job performance at PT. Pamapersada Nusantara. Despite these limitations, this study contributes to the understanding of the factors that influence job performance in the mining industry and provides insights for practitioners to develop effective interventions to enhance job performance among employees.
Practical implications: The managerial implication of this research is that the company can enhance job satisfaction and work engagement, boost employee performance, achieve their objectives, and acquire a competitive edge. To ensure they meet organisational goals and improve safety, technical and non-technical training programmes must be evaluated. This assessment should assess teacher preparedness, classroom, simulator, and field practise efficacy, training material content, and employee benefits. Companies may boost employee engagement, performance, and safety by strengthening training programmes and meeting employee requirements.
Originality/value: This report originates from research conducted inside a single mining business.
Paper type: Research Paper.
The Effect of Socioeconomic Status and Environmental Factors on Health Technician Students’ Use of Tobacco Products
Authors: KILINÇ Gülser , AÇIKGÖZ Ayla , KILINÇ Oğuz , TOYRAN Neslihan 
Published: January 2024

Purpose: This study was conducted to investigate health technician students’ behaviors regarding the use of tobacco and tobacco products and levels of tobacco dependence and to reveal the effects of socioeconomic and environmental factors on the use of these products.
Materials and methods: The study consisted of 1118 first- and second-year students from Dokuz Eylül University Vocational School of Health Services in the 2021-2022 academic year. These students were applied a questionnaire that was developed to determine their sociodemographic, individual, family characteristics, habits, and opinions on tobacco use and the Fagerström Test for Nicotine Dependence (FTND).
Results: It was determined that 34.5% of the students used tobacco products, 14.0% smoked water pipe (WTS), 3.0% used electronic cigarettes (EC), and that the average age of starting smoking was 15.6±2.4 years. Of the students, 18.1% stated that they wanted to quit smoking and 1.9% had received professional help to quit smoking. It was found that 64.5% did not want tobacco product advertisements to be banned and that 61.9% did not want a smoking ban in public/indoor areas. According to 64.0% of the students, university education had no effect on tobacco use. The mean score of smokers on the FTND was 3.43±2.20, and 3.9% of them had a high level of dependence. It was determined that a low level of tobacco addiction was more prevalent in students whose mothers had low education and who lived with their parents (p
Evaluation of Serum Drug Concentrations in a Tertiary Care Hospital: A Cross-Sectional Study
Authors: BECİT-KIZILKAYA Merve , ONCU Seyma , ÇAVUŞOĞLU Dilek , KOCA Halit Buğra 
Published: January 2024

Background: Serum drug concentration (SDC) is an important parameter used in drug efficacy and treatment follow-up.
Aim: This study aimed to evaluate SDC and the influencing factors for carbamazepine, phenytoin, phenobarbital, lithium and digoxin.
Materials and Methods: This is a cross-sectional study, evaluating the outpatients’ and inpatients’ SDC data treated at Research and Application Hospital of Afyonkarahisar Health Sciences University between January 1, 2012 and December 31, 2019, and having SDC data. The relations between dependent and independent variables was evaluated with chi-square analysis and Students’ T-test. P
„Królestwo jednego języka i jednego prawa jest słabe” – wieloetniczność wczesnośredniowiecznych Węgier
Authors: Grzesik Ryszard 
Published: January 2024

Przynależność etniczna nie stanowiła przed XVIII wiekiem kryterium decydującego o przynależności państwowej. Miano jednak świadomość różnorodności etnicznej istniejącej w ramach jednego kraju, a nawet, że może ona go wzbogacić. Wydaje się, że w panoramie wczesnośredniowiecznych państw Europy Środkowej Węgry od samego początku wyróżniały się swoją mozaiką etniczną. Były to zaszłości okresu przynależności plemion węgierskich do świata Wielkiego Stepu, gdzie powstające związki polityczne spajane były przez charyzmatycznego wodza lub dynastię mającą sakralną legitymację, lecz po ustaniu tych czynników związki te zanikały. Mogły po nich pozostać ślady w zbiorowej pamięci, jak w przypadku Attyli, lecz poszczególne plemiona rozchodziły się i znajdowały swe miejsce w nowych związkach, zazwyczaj wieloplemiennych.Taki charakter miał plemienny związek węgierski, do którego obok ugrofińskich Madziarów należeli Kabarowie, czyli odłam Chazarów, który zbuntował się przeciwko swoim współplemieńcom, oraz Szeklerzy, którzy jako domniemani nosiciele tradycji o Attyli mogli być potomkami Hunów, krewnymi Onogurów – Protobułgarów. Obie te grupy szybko się zmadziaryzowały, a na nowym miejscu osiedlane były przy granicach państwa, tworząc jego pierwszą linię obronną. Taką rolę odgrywali też późniejsi przybysze na ziemie Kotliny Karpackiej: Pieczyngowie, Kumani oraz nieomówieni w artykule Sasi, muzułmanie i Rusini. Byli oni pierwszym źródłem, które zasilało węgierską mozaikę etniczną. Drugie źródło stanowili słowiańscy czy słowiańsko-awarscy tubylcy zamieszkujący te ziemie w chwili przybycia Węgrów. Pojawienie się Węgrów nie oznaczało eksterminacji tej ludności – stała się ona częścią kształtującego się społeczeństwa węgierskiego, zajmując jednak jako ludność chłopska dolne szczeble drabiny społecznej. Wydaje się również, że dotychczasowe elity podjęły współpracę z najeźdźcami, a ich potomkowie stali się częścią elity węgierskiej, jak np. ród Hont-Pázmány albo Miskolcowie. Kontakt z przybyszami i tubylcami zasilił węgierską tradycję historyczną nowymi elementami, np. pamięcią o pasterzach rzymskich, w których Gyula Kristó widział frankijskich (salzburskich) (dusz)pasterzy działających na terenie księstwa panońskiego.
Nasilje v športu med mladimi športniki
Authors: Strašek Nika 
Published: January 2024

Nasilje, kot neprimerna oblika vedenja, se vse bolj pojavlja tudi v športu. Vsepogostejše pojavljanje nasilja v športu je posledica aktualnih družbeno - ekonomskih razmer in predvsem poveličevanje pomena zmage, ki postaja pomembnejša od izvornega pomena športa. Z razvojem športa in njegovih panog ter sprememb njegovega pomena v družbi so se razvile nove oblike nasilja v športu. Nasilje je vse bolj prisotno tudi v športnih panogah, kjer nasilja prej nismo poznali. Zavedanje obstoja nasilja v športu in predvsem njegovo prepoznavanje sta ključna elementa v procesu njegovega preprečevanja. V članku smo, skozi rezultate lastne raziskave, izvedene z osebnim anketiranjem mladih športnikov iz različnih športnih panog, ki tekmujejo tako na slovenskih kot na mednarodnih tekmovanjih in skozi številne mednarodne primere opozorili na nekatere njegove negativne učinke, tako na posameznika, kot tudi na celotno družbo. V kolikor pričujoč članek vsaj kanček prispeva k ozaveščanju o problemu nasilja in nasilja v športu ter njegovemu preprečevanju, smo z njim dosegli njegov namen.
The effect of cervical traction on stabilometric parameters in cervical radiculopathy patients: A randomized crossover study
Authors: Jellad Anis , Kalai Amine , Abbes Ilef , Jguirim Mahbouba , Boudokhane Soumaya , Salah Frih Zohra Ben , Bedoui Mohamed Hedi 
Published: January 2024

BACKGROUND: Cervical traction is effective on pain and function in patients with cervical radiculopathy but its effectiveness on balance disorders has not yet been studied. OBJECTIVE: To evaluate the effect of mechanical intermittent cervical traction (MICT) on stabilometric parameters in patients with cervical radiculopathy. METHODS: This randomized crossover study assigned 20 patients with cervical radiculopathy to one of the two groups: Group effective traction (ET)/sham traction (ST) (n= 10) treated firstly with ET (traction force of 12 Kg) then with ST (traction force of 2 Kg) with one-week interval and group ST/ET (n= 10) treated invertedly with a ST then ET. Each traction procedure was maintained for 10 minutes twice separated by 5 minutes of rest. Patients were assessed before and immediately after MICT procedure. Main outcome measures were stabilometric parameters: center of pressure, sway area and lateral and anteroposterior displacements using a force platform. Secondary outcome measures were pain intensity, grip strength and dizziness. RESULTS: ET has provided a significantly greater improvement in both groups and in the total population in terms of stabilometric parameters (p< 0.01), pain intensity, and grip strength (p< 0.05), compared to ST. CONCLUSION: MICT seems to have an immediate beneficial effect on stabilometric parameters, pain and grip strength in patients with cervical radiculopathy.
Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters
Authors: Záveský Luděk , Jandáková Eva , Weinberger Vít , Minář Luboš , Kohoutová Milada , Slanař Ondřej 
Published: January 2024

BACKGROUND: Breast cancer is the most commonly occurring cancer worldwide and is the main cause of death from cancer in women. Novel biomarkers are highly warranted for this disease. OBJECTIVE: Evaluation of novel long non-coding RNAs biomarkers for breast cancer. METHODS: The study comprised the analysis of the expression of 71 candidate lncRNAs via screening, six of which (four underexpressed, two overexpressed) were validated and analyzed by qPCR in tumor tissues associated with NST breast carcinomas, compared with the benign samples and with respect to their clinicopathological characteristics. RESULTS: The results indicated the tumor suppressor roles of PTENP1, GNG12-AS1, MEG3 and MAGI2-AS3. Low levels of both PTENP1 and GNG12-AS1 were associated with worsened progression-free and overall survival rates. The reduced expression of GNG12-AS1 was linked to the advanced stage. A higher grade was associated with the lower expression of PTENP1, GNG12-AS1 and MAGI2-AS3. Reduced levels of both MEG3 and PTENP1 were linked to Ki-67 positivity. The NRSN2-AS1 and UCA1 lncRNAs were overexpressed; higher levels of UCA1 were associated with multifocality. CONCLUSIONS: The results suggest that the investigated lncRNAs may play important roles in breast cancer and comprise a potential factor that should be further evaluated in clinical studies.
Facioscapulohumeral Muscular Dystrophy European Patient Survey: Assessing Patient Reported Disease Burden and Preferences in Clinical Trial Participation
Authors: McNiff Megan M. , Hawkins Sheila , Haase Bine , Bullivant Joanne , McIver Tammy , Mitelman Olga , Emery Nicholas , Tasca Giorgio , Voermans Nicol , Diaz-Manera Jordi 
Published: January 2024

Background: Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disorder characterized by progressive muscle weakness leading to permanent disability. There are no curative treatments, however, there are several upcoming clinical trials testing new therapies in FSHD. Objective: This study aimed to explore the disease burden and patient preferences of people with FSHD to ensure that clinical trials can be designed to include outcome measures that are relevant and important to patients. Methods: A survey was developed with a steering committee clinicians and physiotherapists with relevant experience in the disease, patient representatives, a registry expert and industry consultants. Themes of the survey included; participant demographics, disease progression and impact on function, factors encouraging or discouraging clinical trial participation, and positive outcomes of a clinical trial. Results: 1147 participants responded to the online survey, representing 26 countries across Europe and a range of disease severities. The study highlighted the key symptoms causing concern for FSHD patients - muscle weakness and mobility issues - reflecting what participants want targeted for future therapies. The need for clear information and communication throughout clinical trials was emphasised. Factors most encouraging trial participation included access to new investigational therapies, access to trial results and benefits for the FSHD community. Factors most discouraging trial participation included travel related issues and fear of side effects. Conclusions: The results from this study identify the patient reported burden of FSHD and should provide researchers and industry with areas of therapeutic research that would be meaningful to patients, as well as supporting the development of patient centric outcome measures in clinical trials.
Reflections on statistical leadership: Summary of a panel discussion at the WSC 2023
Authors: Penneck Stephen , Bailer John , Humpherson Ed , Kotzeva Mariana , Silva Denise 
Published: January 2024

What qualities are needed by statisticians to achieve top leadership positions in academia, business, industry and government? Five leaders from statistical societies, national and international statistical offices, and academia share their experiences. They respond to five specific questions. Firstly, is leadership just needed by top management or do all statisticians have a role? If so, what is it? Secondly, do statisticians naturally make good leaders? What new skills do they need to acquire? What skills advantages do they have? Thirdly, the panel consider the question: did you work for people who were not good leaders? How did they fall short? What good role models did panellists have? And then, is it harder for women, and for other under-represented groups? And finally they were asked: what message do you have for young statisticians aspiring to leadership roles?
GERAKAN IBU HAMIL CEGAH PENDERITA ANEMIA DI DESA BELIMBING SARI KECAMATAN JABUNG LAMPUNG TIMUR
Authors: Susilowati Eka , Susilawati Susilawati 
Published: January 2024

Menurut WHO (2013), berkisar 20% dan 89% ibu hamil mengalami kejadian anemia dengan menetapkan Hemoglobin 11 g% sebagai dasarnya. Sekitar 70% ibu hamil di Indonesia mengalami anemia akibat kekurangan gizi terutama zat besi. Kekurangan zat besi pada ibu hamil dapat meningkatkan resiko kematian pada saat melahirkan, bayi lahir dengan BBLR, keguguran dan resiko bayi lahir premature. Vitamin C dapat meningkatkan penyerapan besi non heme sebesar empat kali lipat dan dengan jumlah 200 mg akan meningkatkan absorpsi besi sedikitnya 30% (Goodman, 2008). Buah jambu biji mengandung asam askorbat2 kali lipat dari jeruk yaitu sekitar 87 mg/100 gram jambu biji. Tanaman jambu biji mudah ditemukan dan lebih ekonomis, sehingga hal tersebut menjadi salah satu alasan pemilihan bahan menjadi produk untuk intervensi. Selain itu, jambu biji merah juga kaya akan vitamin dan mineral. Kandungan vitamin C jambu biji merah dapat meningkatkan kualitas absorbsi zat besi dalam tubuh sehingga kadar hemoglobin ibu hamil akan meningkat. Kata Kunci : Jambu Biji Merah, Kadar Hemoglobin, Ibu Hamil
Venoarterial extracorporeal membrane oxygenation for vasoplegic shock after treprostinil refill of an implanted intravenous pump: a case report
Authors: Valencia Lucía , López Sergio , Olivas Ana , Becerra Ángel , Alemán-Segura María Desirée , Évora-García Marta , Ojeda Nazario , Cabrera Leonardo , Rodríguez-Pérez Aurelio , Pérez-Peñate Gregorio 
Published: January 2024

IntroductionVenoarterial extracorporeal membrane oxygenation (ECMO) is a rescue therapy that can stabilize patients with hemodynamic compromise. Indications continue to evolve, including drug overdose. However, the indication merely for vasoplegic shock following drug overdose is controversial.Case summaryWe report a case of a 57-year-old male with high-risk idiopathic pulmonary arterial hypertension treated with upfront triple combination therapy (sildenafil, bosentan, and intravenous treprostinil infusion via subcutaneous abdominal implantable pump). In one of the refills of the drug reservoir, accidental administration of 1 months's supply of treprostinil (200 mg) into the subcutaneous tissue occurred, causing refractory vasoplegic shock. He required urgent VA-ECMO for 96 h, surviving to discharge 28 days later.DiscussionTreprostinil poisoning is rare due to its less frequent use but is life-threatening. ECMO may be considered in vasoplegic shock due to overdose of vasodilatory medication. It allows organ perfusion to be maintained, with the knowledge that recovery is as rapid as drug elimination.
A framework towards digital twins for type 2 diabetes
Authors: Zhang Yue , Qin Guangrong , Aguilar Boris , Rappaport Noa , Yurkovich James T. , Pflieger Lance , Huang Sui , Hood Leroy , Shmulevich Ilya 
Published: January 2024

IntroductionA digital twin is a virtual representation of a patient's disease, facilitating real-time monitoring, analysis, and simulation. This enables the prediction of disease progression, optimization of care delivery, and improvement of outcomes.MethodsHere, we introduce a digital twin framework for type 2 diabetes (T2D) that integrates machine learning with multiomic data, knowledge graphs, and mechanistic models. By analyzing a substantial multiomic and clinical dataset, we constructed predictive machine learning models to forecast disease progression. Furthermore, knowledge graphs were employed to elucidate and contextualize multiomic–disease relationships.Results and discussionOur findings not only reaffirm known targetable disease components but also spotlight novel ones, unveiled through this integrated approach. The versatile components presented in this study can be incorporated into a digital twin system, enhancing our grasp of diseases and propelling the advancement of precision medicine.
The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes
Authors: Wang Qian , Cheng Haimei , Jiang Shuangshuang , Zhang Li , Liu Xiaomin , Chen Pu , Liu Jiaona , Li Ying , Liu Xiaocui , Wang Liqiang , Li Zhaohui , Cai Guangyan , Chen Xiangmei , Dong Zheyi 
Published: January 2024

ContextDiabetic retinopathy (DR) and diabetic nephropathy (DN), are major microvascular complications of diabetes. DR is an important predictor of DN, but the relationship between the severity of DR and the pathological severity of diabetic glomerulopathy remains unclear.ObjectiveTo investigate the relationship between severity of diabetic retinopathy (DR) and histological changes and clinical indicators of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM)MethodsPatients with T2DM (n=272) who underwent a renal biopsy were eligible. Severity of DR was classified as non-diabetic retinopathy, non-proliferative retinopathy, and proliferative retinopathy (PDR). Relationship between DN and DR and the diagnostic efficacy of DR for DN were explored.ResultsDN had a higher prevalence of DR (86.4%) and DR was more severe. The sensitivity and specificity of DR in DN were 86.4% and 78.8%, while PDR was 26.4% and 98.5%, respectively. In DN patients, the severity of glomerular lesions (p=0.001) and prevalence of KW nodules (p&lt;0.001) significantly increased with increasing severity of DR. The presence of KW nodules, lower hemoglobin levels, and younger age were independent risk factors associated with more severe DR in patients with DN.ConclusionDR was a good predictor of DN. In DN patients, the severity of DR was associated with glomerular injury, and presence of KW nodules, lower hemoglobin levels and younger age were independent risk factors associated with more severe DR.Trial registrationClinicalTrails.gov, NCT03865914.