bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro comparison of physical characteristics of milled versus printed zirconia discs
Authors: Giugliano Thomas S. , Zhang Yu , Janal Malvin N. , Lim Chek Hai , Smith Ruby M. , Choi Mijin 
Published: September 2023

AbstractPurposeThe purpose of this study was to compare the dimensional accuracy, translucency, and biaxial flexural strength of milled zirconia (MZ) versus 3D‐printed zirconia (PZ) discs.Materials & MethodsA circular disc measuring 14.0 mm in diameter and 1.20 mm in thickness was designed using computer‐aided design (CAD) software. The resulting standard tessellation language (STL) file was used both as a control and to fabricate 36 zirconia (3Y‐TZP) disc specimens (n = 36): 18 were milled (group MZ) and 18 were 3D‐printed (group PZ). The diameter and thickness of each disc were measured using a digital caliper. Translucency was evaluated using a calibrated dental colorimeter. The flexural strength was determined using the piston‐on‐three‐ball biaxial flexure test. All measurements were done by one blinded examiner. The statistical significance level was set to α = 0.05.ResultsThe MZ discs had significantly more accurate dimensions than the PZ discs in both diameter and thickness when compared to the control CAD software‐designed disc. The MZ discs exhibited significantly higher translucency (translucency parameter (TP) = 16.95 ±0.36 vs. 9.24 ±1.98) and biaxial flexural strength (996.16 ±137.37 MPa vs. 845.75 ±266.16 MPa) than the PZ discs. Finally, MZ possessed a significantly higher Weibull modulus relative to PZ.ConclusionsThe results showed that the milled specimens achieved better dimensional accuracy and were more translucent, stronger, and less prone to failure than printed specimens.
Evaluating the impact of a child sponsorship programme on paediatric health and development in Calauan, Philippines: A retrospective audit
Authors: Raupach Arabella K , Faraj Daniel , Anning Kristie‐Lee , Willcock Helen , Hespe Charlotte 
Published: September 2023

AimInternational child sponsorship programmes comprise a considerable proportion of global aid accessible to the general population. Team Philippines (TP), a health care and welfare initiative run in association with the University of Notre Dame Sydney since 2013, leads a holistic sponsorship programme for 30 children from Calauan, Philippines. To date, empirical research has not been performed into the overall success and impact of the TP child sponsorship programme. As such, this study aims to evaluate its effectiveness in improving paediatric outcomes.MethodsStudy cohorts comprised 30 sponsored and 29 age‐ and gender‐matched non‐sponsored children. Data were extracted from the TP Medical Director database and life‐style questionnaires for July–November 2019. Outcome measures included anthropometry, markers of medical health, dental health, exercise, and diet. Statistical analyses were performed in SPSS.ResultsSponsorship resulted in fewer medical diagnoses and prescription medications, superior dental health, and improved diet. Further, sponsored children may show a clinically significant trend towards improved physical health. Sponsorship did not affect growth and development metrics, or levels of physical activity.ConclusionsThe TP child sponsorship programme significantly impacts positive paediatric health outcomes in the Calauan community. The strength of the programme lies in its holistic, sustainable, and community‐based model, which is enabled by effective international child sponsorship. This study further supports the relationship between supporting early livelihood and improved health in the paediatric population.
Morphological and molecular characterization of Fusarium incarnatum as a causal disease agent of pepper (Capsicum annuum) fruit rot
Authors: Soylu Soner , Atay Mehmet , Kara Merve , Uysal Aysun , Soylu Emine Mine , Kurt Şener 
Published: September 2023

AbstractChilli pepper (Capsicum annuum L.) is one of the most important commercially cultivated and consumed vegetables in Turkey. During a disease survey, typical symptoms of fruit rot were observed on mature chilli pepper fruits in several surveyed fields and on dried pepper fruits obtained from local retailers/bazaars in Hatay Province, Turkey. Disease incidence varied from 15 to 45% of the plants in the inspected fields. Following standard isolation procedures, 40 fungal isolates were isolated, purified and single‐spore cultures were obtained from surface‐disinfected, rotted dried pepper tissue. Of these isolates, six fungal isolates with dense, cottony white aerial mycelia that became beige with age, were isolated on a potato sucrose agar. All isolates were found to be pathogenic on artificially inoculated chilli pepper fruit. Based on morphological characteristics, the isolates were initially identified as Fusarium incarnatum (Desm.) Sacc. 1886. Morphological identification of F. incarnatum isolates was further confirmed by MALDI‐TOF and molecular analyses using the sequences of the internal transcribed spacer (ITS), partial translation elongation factor‐1α (TEF‐1α) and second largest subunit of RNA polymerase II (RPB2) loci. Phylogenetic analysis based on ITS, TEF‐1α, RPB2 and concatenation of TEF‐1α, RPB2 loci sequences performed with several isolates of Fusarium spp. confirmed that representative fungal isolates (MKUZF1 and MKUZF4) belong to F. incarnatum. To our knowledge, this is the first report of F. incarnatum causing fruit rot in chilli peppers grown in Turkey.
Idiopathic functional urinary outflow tract obstruction in dogs, a retrospective case series (2010‐2021): 31 cases
Authors: Mathews Kathrina , Toedebusch Christine , Palm Carrie , Kendall Allison , Westropp Jodi L. 
Published: September 2023

AbstractBackgroundIdiopathic functional urinary outflow tract obstruction (iFUOTO) is an uncommon but life‐limiting disease whose etiology and clinical course of disease remain poorly understood.ObjectiveCharacterize signalment, clinical signs, clinicopathologic findings, treatments, and propose a standardized response score for dogs with iFUOTO.AnimalsThirty‐one client‐owned dogs diagnosed with iFUOTO.MethodsRetrospective case series. Medical records from 2010 to 2021 were reviewed and findings recorded. Dogs were categorized based on the presence or absence of overt signs of neurological disease. Response to treatment was scored.ResultsThirty‐one dogs were included. All dogs had stranguria and 14 (45%) had overflow urinary incontinence. Mean age of onset for signs was 6.9 years±8 months. Twenty‐four dogs (77%) were castrated males, 5 (16%) intact males, and 2 (6%) spayed females. Eight (26%) of dogs had overt neurological deficits. Follow‐up data were available for 29 dogs (median 38 days, range: 2‐1277). Final outcome scores were not significantly different among dogs with overt signs of neurological disease (median score 2.5; range: 0‐3) and those without (median score 1; range; 0‐3; P = .35). Treatments included alpha antagonists, skeletal muscle relaxants, parasympathomimetics, anti‐inflammatories, castration, temporary placement of a urethral catheter, or a combination of these.Conclusions and Clinical RelevanceMultimodal treatment was frequently prescribed, but a standard outcome score is needed to evaluate the effectiveness of these therapies. Serial neurological examinations and monitoring of the dogs' dysuria are warranted.
Pharmacokinetics of pimobendan after oral administration to dogs with myxomatous mitral valve disease
Authors: McManamey Anna K. , DeFrancesco Teresa C. , Meurs Kathryn M. , Papich Mark G. 
Published: September 2023

AbstractBackgroundPimobendan is an important therapy for dogs with myxomatous mitral valve disease (MMVD). The pharmacokinetics are reported in healthy dogs but not in dogs with heart disease.Hypothesis/ObjectivesTo determine if dog characteristics such as age, breed, body condition score, ACVIM stage of heart disease or biochemical laboratory value alter the pharmacokinetics of orally administered pimobendan and its metabolite in a cohort of dogs with naturally occurring MMVD.AnimalsFifty‐seven client‐owned dogs with MMVD ACVIM Stage B2, C, or D and administered pimobendan to steady state blood concentrations.MethodsProspective, observational study. Samples were collected using a sparse‐sampling protocol at specific intervals after administration of pimobendan. Plasma pimobendan and the active metabolite (O‐desmethyl‐pimobendan, ODMP) concentrations were determined via high‐pressure liquid chromatography and fluorescence detection. Data was analyzed via a population pharmacokinetic approach and nonlinear mixed effects modeling (NLME). Numerous covariates were examined in the NLME model.ResultsThe absorption and elimination half‐lives (t1/2) were approximately 1.4 and 1 hour for pimobendan and 1.4 and 1.3 hours for ODMP, respectively. Pharmacokinetic parameters were highly variable, especially the values for pimobendan absorption and elimination rate, and absorption rate of ODMP with coefficients of variation of 147.84%, 64.51% and 64.49%, respectively. No covariate evaluated was a significant source of variability.Conclusions and Clinical ImportanceThe pharmacokinetic parameters were highly variable among this group of dogs with MMVD. The variability was not associated with the dog's age, body weight or condition score, stage of heart disease, dose, serum creatinine, or alkaline phosphatase.
Cultural adaptation and validation of the Quality of Dying in Long‐term Care (QoD‐LTC and QoD‐LTC‐C) scales by caregivers in nursing homes
Authors: Puente‐Fernández Daniel , Soto Felipe Carmen , Mota‐Romero Emilio , Esteban‐Burgos Ana Alejandra , Montoya‐Juárez Rafael , Roldan‐Lopez de Hierro Concepción Beatriz 
Published: October 2023

AbstractBackgroundThere is a lack of tools that can evaluate quality of dying in nursing homes from the perspective of deceased patients' caregivers. The aim of this study was to adapt and validate the caregivers' versions of the Quality of Dying in Long‐Term Care (QoD‐LTC) and Quality of Dying in Long‐Term Care Complete (QoD‐LTC‐C) scales in the Spanish context.MethodsThis was a cultural adaptation and validation study. The scales were translated from English to Spanish and vice versa, and 13 experts in end‐of‐life care participated in a two‐round Delphi panel. Caregivers of 69 deceased residents from seven nursing homes in southern Spain completed both scales. Reliability, feasibility, and concurrent validity with global quality of dying perception and symptom burden (Edmonton Symptom Assessment Scale), were evaluated.ResultsSpanish caregivers' version of the QoD‐LTC scale showed good internal consistency for the total scale (α = 0.74) and each of its three factors, and good inter‐rater reliability (ICC = 0.50) and test–retest reliability (ICC = 0.81). The Spanish QoD‐LTC‐C scale for caregivers showed good internal consistency for the total scale (α = 0.81) and for its component factors, and good test–retest reliability (ICC = 0.89) and inter‐rater reliability (ICC = 0.66). Both scales correlated with family caregivers' global perception of deceased residents' quality of dying (r = 0.39; r = 0.32), but not with the ESAS score.ConclusionsBoth scales presented an adequate factorial structure, internal consistency, and reliability to assess caregivers' perception of the quality of dying in Spanish nursing homes.
How do we translate gaps and unmet needs of blood management for thalassemia into a collaborative implementation framework?
Authors: Limwongse Chanin , Rojnuckarin Ponlapat , Kupatawintu Pawinee , Thongthaisin Aphisit , Permpikul Parichart , Kitpoka Pimpan , Watanaboonyongcharoen Phandee , Sucharitchan Pranee , Torcharus Kitti , Fucharoen Suthat , Kongpakwattana Khachen , Nerapusee Osot , Chuncharunee Suporn 
Published: September 2023

AbstractBackground and ObjectiveThe mainstay of management for thalassemia is regular blood transfusions. However, gaps and unmet needs of blood services for thalassemia are still not clearly identified and addressed in Thailand, a country prevalent with thalassemia. What can be a collaborative implementation framework that helps advance practices and policies relating to blood management for thalassemia?MethodsThe first Blood & Beyond Roundtable Discussion was held in July 2022 to gather the current situation, gaps, and unmet needs of blood services for thalassemia from multidisciplinary experts and thalassemic patients. The Implementation Guide as suggested by the Centre for Effective Services was applied as a tool to consolidate information from the discussions and construct the collaborative implementation framework.ResultsThe National Blood Center and hospitals in Thailand followed the missions specified in the National Blood Policy and the standard guidelines to ensure the best practice of blood management for thalassemia. However, there were six gaps and unmet needs identified from the discussions. After all discussion points were mapped onto the framework, an implementation plan comprised of five specific activities became clear and actionable.ConclusionWithout the complete information from both experts and patients, the implementation plan would not have been successfully constructed. The method that we employed to translate all information into the framework can be adapted by other countries to develop their own specific framework efficiently.
Claw bed inverted squamous papilloma associated with canine papillomavirus type 2 in a dog
Authors: Resendes Ana R. , Trainor Karen E. , Bera Monali , Cheng Ryan Chuang Fu , Luff Jennifer 
Published: October 2023

AbstractA claw bed inverted squamous papilloma (ISP) presented clinically as a swollen digit in a dog. Canine papillomavirus (CPV) type 2 was amplified by PCR and localised to the papilloma's epidermis using in situ hybridisation. This is the first report demonstrating a claw bed ISP caused by CPV.
Comparison of Thrombolysis In Cerebral Infarction (TICI) 2b and TICI 3 reperfusion in endovascular therapy for large ischemic anterior circulation strokes
Authors: Winkelmeier Laurens , Faizy Tobias D , Brekenfeld Caspar , Heitkamp Christian , Broocks Gabriel , Bechstein Matthias , Steffen Paul , Schell Maximilian , Gellissen Susanne , Kniep Helge , Thomalla Goetz , Fiehler Jens , Flottmann Fabian 
Published: September 2023

BackgroundLandmark thrombectomy trials have provided evidence that selected patients with large ischemic stroke benefit from successful endovascular therapy, commonly defined as incomplete (modified Thrombolysis In Cerebral Infarction (mTICI) 2b) or complete reperfusion (mTICI 3). We aimed to investigate whether mTICI 3 improves functional outcomes compared with mTICI 2b in large ischemic strokes.MethodsThis retrospective multicenter cohort study was conducted to compare mTICI 2b versus mTICI 3 in large ischemic strokes in the anterior circulation. Patients enrolled in the German Stroke Registry between 2015–2021 were analyzed. Large ischemic stroke was defined as an Alberta Stroke Program Early CT Score (ASPECTS) of 3–5. Patients were matched by final mTICI grade using propensity score matching. Primary outcome was the 90-day modified Rankin Scale (mRS) score.ResultsAfter matching, 226 patients were included. Baseline and imaging characteristics were balanced between mTICI 2b and mTICI 3 patients. There was no shift on the mRS favoring mTICI 3 compared with mTICI 2b in large ischemic strokes (adjusted common odds ratio (acOR) 1.12, 95% confidence interval (95% CI) 0.64 to 1.94, P=0.70). The rate of symptomatic intracranial hemorrhage was higher in mTICI 2b than in mTICI 3 patients (12.6% vs 4.5%, P=0.03). Mortality at 90 days did not differ between mTICI 3 and mTICI 2b (33.6% vs 37.2%; adjusted OR 0.69, 95% CI 0.33 to 1.45, P=0.33).ConclusionsIn endovascular therapy for large ischemic strokes, mTICI 3 was not associated with better 90-day functional outcomes compared with mTICI 2b. This study suggests that mTICI 2b might be warranted as the final angiographic result, questioning the benefit/risk ratio of additional maneuvers to seek for mTICI 3 in large ischemic strokes.Trial registration numberNCT03356392.
Tigertriever in the treatment of acute ischemic stroke with underlying intracranial atherosclerotic disease
Authors: Ojeda Diego J , Ghannam Malik , Sanchez Sebastian , Almajali Mohammad , Koul Prateeka , Saver Jeffrey L , Gupta Rishi , Ortega-Gutierrez Santiago , Liebeskind David S , Samaniego Edgar A 
Published: September 2023

BackgroundThe Tigertriever device offers a unique feature that enables gradual control of the radial expansion. We sought to evaluate the safety and efficacy of the Tigertriever device in patients with large vessel occlusion (LVO) and underlying intracranial atherosclerotic disease (ICAD). The patients were part of the TIGER trial.MethodsThe presence of underlying ICAD was determined by a core imaging laboratory using CT angiography and digital subtraction angiography. The primary outcomes included successful reperfusion, puncture to reperfusion time, and complications associated with the use of the Tigertriever device. Patients underwent mechanical thrombectomy with the Tigertriever device for up to three passes, and alternative devices were employed for subsequent passes.ResultsA total of 160 patients were enrolled in the TIGER trial, and 32 patients had ICAD. Among the patients with ICAD, 78% achieved successful reperfusion within three passes of the Tigertriever device, without requiring rescue therapy. Additionally, a first pass effect was observed in 46.8%. The median time from puncture to reperfusion was 22 minutes. There were no device-related complications. The National Institutes of Health Stroke Scale (NIHSS) score at 24 hours was significantly reduced, from an average of 17 at baseline to 8. At the 3 month follow-up, 50% of patients achieved a modified Rankin Scale score of ≤2.ConclusionEndovascular therapy (EVT) with the Tigertriever device for LVO in patients with underlying ICAD is effective and safe. When compared with historical data from other devices employed in similar cases, we observed a high rate of successful reperfusion, along with a shorter puncture to reperfusion time.
Do Innovation and Institutional Quality Elevate Economic Growth? Empirical Evidence from Developing Countries
Authors: Pradhan Rudra P. , Arvin Mak B. , Nair Mahendhiran S. , Bennett Sara E. , Brem Alexander 
Published: September 2023

Research Highlights • An assessment of institutional quality, innovation, and economic growth in developing countries. • Long-run causality from innovation and institutional quality to economic growth is present. • Short-run directions of causality are varied among variables of interest. • Innovation and institutional quality generally positively impact economic growth. Continuous innovation is the lifeblood of a competitive economy. Furthermore, and arguably, the existence of institutions of governance of quality can be a catalyst for emerging economies to transition up the universal innovation value chain. In this context, we investigate temporal causal interactions among institutional quality, innovation, and economic growth for developing countries (DCs) spanning the period of 2005–2020. Employing a vector error-correction model (VECM), we find that for each case and specification (49 instances), there is evidence of the long-run causality from institutional quality and innovation to economic growth. Stated another way, in the long run, institutional quality and innovation Granger-cause economic growth. However, the short-run causality results differ depending on the specific measures of innovation and institutional quality. The strongest short-run conclusion is support for the feedback hypothesis for economic growth and innovation where there is a strong endogenous relationship between innovation, institutional governance, and economic growth. The empirical analysis shows over 70% of our observations support that economic growth and innovation jointly determine each other in the short run. The results suggest that DCs should develop and pursue long-term growth strategies that simultaneously develop innovation and improve institutional governance.
INDIVIDUAL CORRELATION OF OXYGEN DELIVERY WITH HAEMOGLOBIN LEVEL IN 20-YEAR-OLD WOMAN WITH HB 1.8 WITH INCOMPATIBLE CROSS-MATCH RESULTS: CASE REPORT STUDY
Authors: Permana Septian Adi , Yuliana Friskha 
Published: October 2023

BACKGROUND
Clinical assessment of the delivery of tissue oxygenation is very challenging for clinicians to study. Anaemia reflects a decrease in oxygen carrying capacity in the blood which is very at risk of oxygen delivery (DO2) insufficiency and cellular hypoxemia, to assess tissue hypoxia in addition to being a reliable tool, the clinician must also adjust to the patient's clinical and hemodynamic. Blood transfusions are generally used to correct anaemia precisely and efficiently, but in certain circumstances that make it impossible for clinicians to perform blood transfusions, at that time we have to think of other methods of therapy in patients.
METHODS
20-year-old woman came with anaemia, with a haemoglobin (Hb) level of 6.0 g/dl, a stable clinical condition and hemodynamic within normal limits, a blood transfusion was planned but the results of the Comb test was incompatible, so it was an absolute contraindication for transfusion. The patient experienced clinical changes that indicated the occurrence of tissue hypoxia when the Hb level was 2.0gr/dl. The clinician decided to maximize DO2, and reduce oxygen demand/consumption (VO2), so that there is a balance. The patient was treated with steroids, suspected autoimmune haemolytic anaemia (AIHA). On the eighth day of clinical treatment the patient improved, hemodynamically stable, and Hb increased.
CONCLUSION
Clinical valuation of the distribution of tissue oxygenation is very important for AIHA patient.
TWIN TO TWIN TRANSFUSION SYNDROME APA YANG DAPAT KITA LAKUKAN DI PERIFER?
Authors: Bachnas Muhammad Adrianes 
Published: October 2023

PENDAHULUAN
Twin-Twin transfusion syndrome (TTTS) merupakan tantangan tersendiri bagi perifer. Hingga saat ini Fetoscopic laser photocoagulation (FLP) baru tersedia satu di seluruh Indonesia, yaitu di RSAB Harapan Kita, Jakarta. Sementara menurut perhitungan rasio kejadian TTTS terhadap angka kelahiran di Indonesia, tidak kurang dari 3000 kasus TTTS terjadi pertahunnya. Artinya, 10 kasus perhari membutuhkan tindakan tersebut. Maka bila di satu senter layak mengerjakan maksimal 3 kasus maka dibutuhkan 3-4 senter fetoskopi di Indonesia. Sementara kita menunggu terbitnya senter fetoskopi selain RSAB Harapan Kita Jakarta, maka apa yang mungkin dan bisa kita lakukan?
TUJUAN
Memberikan gagasan manajemen TTTS untuk daerah perifer berbasis telaah literatur beserta telaah kasus serial yang ditangani. Metode: Serial Kasus
HASIL
Empat kasus TTTS terdiagnosis rata-rata pada minggu 26.5 kehamilan (dari 23 – 29 minggu). Satu kasus datang sudah dalam persalinan tanpa intervensi. Satu kasus dilakukan amnnioreduksi. Dua kasus dapat dilakukan 50% dilakukan septostomi dan amnioreduksi. Lama waktu dari intervensi sampai dengan bayi lahir 19.6 hari. Didapatkan 100% (8 bayi) lahir hidup, tetapi hanya 37.5% (3 bayi) yang dapat bertahan hidup. Dua bayi lahir dari ibu yang sama dengan usia kehamilan 36 minggu, sayang bayi resipien meninggal beberapa saat setelah dilahirkan. Pada kasus lain Satu bayi donor juga berhasil bertahan hidup pasca tindakan septostomi yang lahir pada usia 32 minggu sementara resipien meninggal pasca salin. Cara persalinan, 50% (2 kasus) pervaginam dan 50% (2 kasus) perabdominam.
KESIMPULAN
Tindakan pertama terpilih untuk TTTS adalah fetoskopi dan laser ablasi dengan angka keselamatan kedua janin lebih dari 90%, hanya saja dikarenakan fasilitas ini belum tersedia di RSUD Dr. Moewardi maka diambil pilihan kedua, yaitu melakukan septostomi dan amnioreduksi. Tindakan septostomy dapat mencegah kompresi tali pusat pada janin donor akibat oligohidramnion, sehingga mengurangi probabilitas kematian intrauterin. Tindakan amnioreduksi dilakukan simultan setelah septostomy dapat mengurangi dypsnea dan nyeri perut akibat overdistensi serta prematuritas. Timing septostomi dan amnioreduksi ternyata sangat menentukan untuk setidaknya dapat menolong salah satu janin.