bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal association between constipation and risk of colorectal cancer: a bidirectional two-sample Mendelian randomization study
Authors: Wu Long , Wu Huan , Huang Fei , Li Xiao-yun , Zhen Yun-huan , Zhang Bao-fang , Li Hai-yang 
Published: November 2023

BackgroundColorectal cancer (CRC) is a globally significant health concern, necessitating effective preventive strategies through identifying modifiable risk factors. Constipation, characterized by infrequent bowel movements or difficulty passing stools, has been proposed as a potential CRC risk factor. However, establishing causal links between constipation and CRC remains challenging due to observational study limitations.MethodsMendelian randomization (MR) utilizes genetic variants as instrumental variables, capitalizing on genetically determined variation to assess causal relationships. In this dual-sample bidirectional MR study, we extracted genetic data from independent cohorts with CRC (Include colon cancer and rectal cancer) and constipation cases. Genome-wide association studies (GWAS) identified constipation and CRC-associated genetic variants used as instruments to infer causality. The bidirectional MR analysis evaluated constipation’s impact on CRC risk and the possibility of reverse causation.ResultsEmploying bidirectional MR, we explored the causal relationship between constipation and CRC using publicly available GWAS data. Analysis of constipation’s effect on CRC identified 26 significant SNPs, all with strong instrumental validity. IVW-random effect analysis suggested a potential causal link [OR = 1.002(1.000, 1.004); P = 0.023], although alternative MR approaches were inconclusive. Investigating CRC’s impact on constipation, 28 significant SNPs were identified, yet IVW analyses found no causal effect [OR = 0.137(0.007, 2.824); P = 0.198]. Other MR methods also yielded no significant causal association. We analyzed constipation separately from colon and rectal cancer using the same methodology in both directions, and no causal relationship was obtained.ConclusionOur bidirectional MR study suggests a potential constipation-CRC link, with mixed MR approach outcomes. Limited evidence supports constipation causing CRC. Reliable instruments, minimal heterogeneity, and robust analyses bolster these findings, enriching understanding. Future research should explore additional factors to enhance comprehension and clinical implications.
Examination of promotive and protective effects on early adolescent prosocial behavior through a bioecological lens
Authors: Bates Elizabeth J. S. , Berny Lauren M. , Ganiban Jody M. , Natsuaki Misaki N. , Neiderhiser Jenae M. , Shaw Daniel S. , Leve Leslie D. 
Published: November 2023

IntroductionProsocial behavior during childhood has been associated with numerous positive developmental and behavioral outcomes in adolescence and adulthood. Prosocial behavior, which includes cooperation and helping others, develops within a bioecological context. Considering it through such a lens enhances the understanding of the roles of different bioecological factors in its development.MethodsUsing data from a longitudinal study of adopted children and children reared with their biological parents, this paper examined if positive aspects of a child’s bioecological system at age 7 predict prosocial behavior in early adolescence (age 11), and whether these bioecological factors could offset risk due to biological family psychopathology and/or maternal prenatal substance use. The analyses incorporated variables from different levels of Bronfenbrenner’s bioecological model (the individual, microsystem, exosystem, and macrosystem) and examined the promotive, and potentially protective, effect of each contextual factor, while also considering their interplay with biological family psychopathology and prenatal substance use.ResultsResults from linear regression models indicated that the microsystem variable of parental warmth at age 7 had a promotive effect on age 11 prosocial behavior. Further, in addition to its main effect, parental warmth was protective against maternal substance use during pregnancy when children were raised with their biological parent (s). Household type (biological family) and biological family internalizing psychopathology were the only other significant predictors in the model, with each associated with lower prosocial behavior at age 11.DiscussionStudy results extend prior work on the benefits of parental warmth on child outcomes by employing a strength-based, bioecological approach to the development of prosocial behavior during early adolescence and examining “for whom” the effects of parental warmth are most protective.
The impact of maternal work–family conflict on problem behaviors among preschoolers during the COVID-19 epidemic: a moderated mediation model of maternal anxiety and trait mindfulness
Authors: Jin Xiuzhen , Ahn Jinkyeong 
Published: November 2023

PurposeThe mediating effects of maternal anxiety and moderating effects of trait mindfulness on the relationship between Work–family conflict (WFC) and preschool children’s problem behaviors remain unclear during the COVID-19 epidemic. So, this study examined the association between mothers’ WFC and preschoolers’ problem behaviors and identified the roles of maternal anxiety as a mediator and trait mindfulness as a moderator during the COVID-19 epidemic.MethodsIn this cross-sectional study, a sample of 1,068 Chinese preschoolers and their mothers from coastal cities in southern China were investigated. Data were collected using demographic questionnaires, Carlson’s WFC scale, Ma’s Parenting Anxiety Scale, Goodman’s SDQ Scale, and Brown and Ryan’s Trait Mindfulness Scale, and were analyzed using SPSS 26.0 and Process 3.3.ResultsWFC had a positive and direct association with problem behaviors in preschoolers (β = 0.118, t = 3.880, p &lt; 0.001). WFC also had a positive and direct association with maternal anxiety (β = 0.480, t = 18.034, p &lt; 0.001). Maternal anxiety had a positive and direct association with preschoolers’ problem behaviors (β = 0.415, t = 13.584, p &lt; 0.001). The mediating effect value of maternal anxiety between WFC and preschoolers’ problem behaviors was 0.199, and the moderating effect value of trait mindfulness between maternal anxiety and preschoolers’ problem behaviors was −0.078.ConclusionWFC was positively associated with preschoolers’ problem behaviors, and maternal anxiety was a mediator of this association. So, WFC could cause maternal anxiety and lead to more problematic behaviors in children. Besides, maternal anxiety was positively associated with preschoolers’ problem behaviors, and trait mindfulness was a moderator of this association.
Effect of fear of missing out on learning burnout in medical students: a moderated mediation
Authors: Ye Xin , Li Yang , Liu Yang , Zheng Qiuyue , Lin Zhongli , Zeng Yinhua , Lin Ziyue , Zhu Tan , Chen Xiayan , Chen Liangliang , Liu Tao 
Published: November 2023

IntroductionLearning burnout has a significant negative impact on students’ academic performance and professional development, which has been exacerbated by the growing trend of problematic smartphone use, such as smartphone addiction, among young people. Recently, the literature on excessive social media use has revealed a critical role of fear of missing out. Objective The purpose of this study was to examine how fear of missing out affects smartphone addiction and its subsequent effect on learning burnout in college students.MethodsIn Study 1, 352 medical students were recruited to complete a cross-sectional survey. In Study 2, 2,948 college students were recruited to complete a cross-sectional survey. Further in Study 3, 30 medical students were recruited into a mindfulness-based intervention program.ResultsStudy 1 preliminarily confirmed that fear of missing out was positively correlated with learning burnout. Study 2 then revealed a moderated mediation model showing that fear of missing out may increase smartphone addiction, which in turn affects their sleep quality and finally leads to learning burnout. This chain mediation model was moderated by the participants’ level of mindfulness. To confirm the promoting role of mindfulness, Study 3 further confirmed that mindfulness training indeed can improve smartphone addiction and reduce learning burnout in medical students.DiscussionTheoretical and practical contributions were discussed, highlighting the effects of fear of missing out on smartphone addiction and a moderating role of mindfulness training.
Energy Transfer in the CaSO4−Dy Thermoluminescent Dosimeter from the Excited State of the SO42− Anionic Complex to the Impurities
Authors: Nurakhmetov Turlybek N. , Alibay Temirulan T. , Zhangylyssov Keleshek B. , Daurenbekov Dulat H. , Salikhodzha Zhussupbek M. , Shamiyeva Raushan K. , Sadykova Batsaiy M. , Yussupbekova Bagila N. , Tolekov Doszhan A. 
Published: November 2023

The creation of a combined radiative state at 2.95–3.1 eV in the phosphor CaSO4−Dy 3+ has been investigated using vacuum ultraviolet and thermoactivation spectroscopy methods. It is shown that the combined radiative electronic state is formed from the radiative electronic states of the impurity electronic trapping centers Dy 2+− SO4− and the intrinsic electronic radiative states SO43−−SO4− during the excitation of the anion complex SO42−, as a result of charge transfer from the excited anion complex O 2−−Dy 3+ to the impurities and the neighboring anion complex O2−− SO42−. In the CaSO4−Dy phosphor, the combined radiative electronic state and impurity emission of Dy 3+, 2.16 eV and 2.56 eV are excited by photons with energies of 3.95–4.0 eV and 4.5–4.6 eV. Energy transfer from the matrix to the Dy 3+ impurities is revealed upon thermal exposure as a result of the ionization of the electronic capture centers of Dy2+ and SO43−.
Recruitment and retention of staff in rural dispensing primary care practice: a qualitative inquiry
Authors: Cross Rosina , McDonagh Sinead TJ , Cockcroft Emma , Turner Malcolm , Isom Matthew , Lambourn Robert , Campbell John L , Clark Christopher E 
Published: November 2023

BackgroundRural primary care practices struggle to employ and retain staff, and existing literature regarding recruitment and retention is focused on doctors. Shortages of qualified staff affect practice functioning, quality of care, and patient experience. Dispensing of medications is a rural service valued by patients. However, little is known about how dispensing services are valued by practices or related to the recruitment and retention of staff.AimTo understand barriers to, and facilitators of, joining and remaining in rural dispensing practice employment, and to explore how rural practices value dispensing services.Design & settingQualitative inquiry in rural primary care practices across England.MethodSemi-structured interviews with rural dispensing staff were undertaken, audio-recorded, transcribed verbatim, and analysed using framework analysis.ResultsIn total, 17 staff from 12 practices across England were interviewed between June and November 2021. Reasons for taking up employment in rural dispensing practices included perceived career autonomy, development opportunities, and preference for working and living in a rural setting. Skills required for dispensers’ roles balanced against low wages were a barrier to recruitment. For nurses, barriers included perceived lack of knowledge around their role in rural care. Revenue from dispensing, opportunities for staff development, job satisfaction, and positive work environments drove retention of staff. However, negative perceptions of rural practice, travel difficulties, lack of applicants, and insufficient remuneration for roles were barriers to retention.ConclusionBarriers to, and facilitators of, rural primary care recruitment and retention vary by role, and include factors unique to the rural setting.
Pulmonary Benign Metastasizing Leiomyoma: A Case Report
Authors: Матылевич О.П. , Курченков Н.А. , Тарасов И.А. , Мавричев С.А. , Копшай П.А. 
Published: November 2023

Доброкачественная метастазирующая лейомиома матки – крайне редкое заболевание, которое сопровождается распространением высокодифференцированной гладкомышечной ткани за пределы матки, в частности в легкие, молочные железы, лимфоузлы, кости, печень, мягкие ткани малого таза, центральную нервную систему, кожу, пищевод, трахею, аппендикс или сердце. Чаще всего при доброкачественной метастазирующей лейомиоме поражаются легкие, что может привести к дыхательной недостаточности. Заболевание следует подозревать у женщин в пременопаузальном возрасте с метастазами в легких, у которых в анамнезе была лейомиома матки. Морфологический метод исследования опухоли является решающим в установлении диагноза. Этиология и патогенез этой патологии неизвестны. Заболевание в большинстве случаев протекает бессимптомно, что затрудняет его выявление. В настоящий момент не существует определенных алгоритмов диагностики и лечения данного заболевания. В статье представлено клиническое наблюдение пациентки с метастазирующей в легкие доброкачественной лейомиомой матки.
Benign metastasizing leiomyoma is an extremely rare condition, when high-differentiated smooth muscle tissue spreads beyond the uterus, including lungs, breast, lymphatic nodes, bones, liver, soft tissue of pelvis, central nervous system, skin, esophagus, trachea, appendix or heart. Lungs are most commonly affected in this disease, which may lead to respiratory failure. Benign metastasizing leiomyoma should be suspected in premenopausal women with metastatic foci in lungs, who had leiomyoma. Morphological investigation is crucial in making diagnosis. Etiology and pathogenesis are unknown. Mostly the disease is asymptomatic, thus the disease is hard to reveal. Currently, there are no guidelines of diagnosis and treatment of this rare condition. Here we present a case report of benign metastasizing leiomyoma.
Phosphodiesterase Type 5 Inhibitors in the Treatment of Lower Urinary Tract Symptoms in Men
Authors: Ниткин Д.М. 
Published: November 2023

Ингибиторы фосфодиэстеразы 5-го типа (ФДЭ-5) значительно улучшают эректильную функцию у мужчин и являются перспективной группой лекарственных средств для лечения пациентов с симптомами нижних мочевых путей (СНМП). В статье представлен обзор применения данной группы лекарственных средств в лечении симптомов нижних мочевых путей у мужчин с позиции доказательной медицины. Тадалафил является ингибитором ФДЭ-5 с доказанной эффективностью применения у пациентов с СНМП с эректильной дисфункцией или без эректильной дисфункции. Тадалафил имеет высокую биодоступность, оптимальную продолжительность действия и надежный профиль безопасности.
PDE-5 inhibitors significantly improve erectile function in men and are a promising group of drugs for the treatment of patients with lower urinary tract symptoms (LUTs). The article presents an overview of the use of PDE-5 inhibitors in the treatment of lower urinary tract symptoms in men from the standpoint of evidence-based medicine. Tadalafil is a PDE-5 inhibitor with proven efficacy in patients with LUTs with or without erectile dysfunction. Tadalafil has high bioavailability, optimal duration of action and a reliable safety profile.
Immunomodulatory Therapy in the Complex Treatment of Chronic Bacterial Prostatitis
Authors: Ниткин Д.М. 
Published: November 2023

В последнее время в комплексном лечении хронического простатита актуальность приобретают методы иммунной модуляции и коррекции. В статье представлены результаты исследования эффективности применения иммуномодулятора Полиоксидоний (азоксимера бромида) в комплексной терапии хронического простатита. Азоксимера бромид в дозе 12 мг в форме ректальных свечей продемонстрировал иммунокорригирующий эффект, а также повысил клиническую и лабораторную эффективность лечения хронического бактериального простатита.
Methods of immune modulation and correction have become relevant in the complex treatment of chronic prostatitis. The article presents the results of a study of the effectiveness of Polyoxidonium (azoximer bromide) in the complex therapy of chronic prostatitis. Azoximer bromide at a dose of 12 mg in the form of rectal suppositories demonstrated an immunocorrecting effect and increased the clinical and laboratory effectiveness of the treatment of chronic bacterial prostatitis.
Comunicación para prevenir el cáncer de piel: un análisis del uso estratégico de la red social Twitter en España
Authors: Jiménez-Sánchez Lara , Moreno Ángeles 
Published: November 2023

Introducción: la sociedad actual se encuentra ante el irrefrenable avance del cáncer de piel, uno de los más comunes y letales a nivel mundial. En España, su incidencia sigue aumentando en la población, y de forma más incipiente, en la población joven. Segmento potencialmente vulnerable a este tipo de cáncer por la alta frecuencia de exposición a la radiación solar sin tomar medidas preventivas, y la cultura del bronceado. Educar en hábitos de fotoprotección es la mejor medida para reducir el riesgo de cáncer de piel. Las redes sociales se han convertido en una plataforma esencial para la concienciación y promoción de comportamientos saludables. El presente estudio identifica y analiza la comunicación sobre prevención del cáncer de piel que se divulga en Twitter en España por los principales emisores estratégicos involucrados en esta labor. Metodología: se realizó análisis de contenido cuantitativo para determinar el primer y segundo nivel de agenda setting de la comunicación. Para ello se recogieron 2486 publicaciones emitidas en Twitter entre los meses de abril a julio de 2022. Resultados: los hallazgos muestran predominio de información relativa al cáncer de piel en general sin especificar, el melanoma y la fotoprotección, enfocada mayoritariamente en las causas de la enfermedad con la exposición solar como principal factor de riesgo. Conclusiones: al final encontramos un desequilibrio en la agenda respecto a temas y encuadres que revela una comunicación insuficientemente optimizada en la red social.
Epidemic: Human Relationships Mutate like Virus
Authors: - Bineet Kaur Chandok 
Published: November 2023

Either war or epidemic, human beings react differently. Epidemics apocalypse T.V. shows and movies capture the human reactions and psychological aspects quite well. The fresh experience of covid-19 has a huge impact on the viewership and readership of epidemic narratives. This paper will analyze the effects of the mutating human psyche and its actions in response to some human feelings concerning the Korean Apocalypse T.V. show, All of us are Dead.
The making of the virus or dealing with the virus can be understood using Newton’s law of action and reaction. For those who read, an Epidemic is an event, but for those who experience it, it is a process. Experience changes the human understanding of the event, but its impact can mutate the human psyche and even compel human beings to react. In the end, it is a human reaction that causes a major threat to the entire humanity.
NEW FIND OF THE SCYTHIAN SWORD NEAR MOTRONYNSKE HILLFORT
Authors: Lyashko Yu. Yu. 
Published: November 2023

In spring 2023 two kilometers south-west of the well-known Motronynske hillfort of Scythian Age on a flat plateau the iron Scythian sword was found out by chance on a little depth. In the Steppe and Forest-Steppe of North Pontic region swords and daggers of this type date to the second half of 6th—5th cc. BC (rather by the first half of the latter century). Near Motronynske hillfort a few finds of Scythian swords and daggers are known but swords of similar type have not occurred before.
The site was examined by the author. It is a flat plateau with small depressions, located near the road to Hruskivka and Kamianka villages. Nearby the kurgan burial ground was located, investigated in 2018 by an expedition headed by O. D. Mohylov.
The sword was found at a depth of 0.5 m from the modern surface, in forest loam. No cultural layer can be traced here but to the south of the site there are remains of defensive structures in the form of an earthen rampart with a moat that covers the plateau spurs from the side of Hruskivka. Near this rampart in 2019, a bronze triangular arrowhead with a spike was found, which according to A. I. Meliukova’s classification belongs to type 1, group 1, division III.
In recent years several more swords and daggers of the 7th—5th centuries BC have been accidentally found in this area of the Kholodnyi Yar tract. This sword has a simple antenna-shaped pommel and butterfly-shaped cross-bar, i. e., according to the well-known classification of A. I. Meliukova, it belongs to the edged weapons of the II department of the 2nd type, which was widespread in the 6th — first half of the 5th century BC. The sword is 61.3 cm long, double-bladed, with a blade tapering in the last third of its length, well preserved. It weighs 650 grams. Finds of the edged weapons of infighting near the largest settlement of the Scythian Age in the Tyasmin-river-basin, presumably, are the evidence of a military collision of it’s inhabitants with the representatives of the nomadic world of Steppe.
OGLE-2019-BLG-1180Lb: Discovery of a Wide-orbit Jupiter-mass Planet around a Late-type Star
Authors: Chung Sun-Ju , Udalski Andrzej , Yee Jennifer C. , Gould Andrew ,   Leading Authors, Albrow Michael D. , Jung Youn Kil , Hwang Kyu-Ha , Han Cheongho , Ryu Yoon-Hyun , Shin In-Gu , Shvartzvald Yossi , Yang Hongjing , Zang Weicheng , Cha Sang-Mok , Kim Dong-Jin , Kim Seung-Lee , Lee Chung-Uk , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W. ,   The KMTNet collaboration, Poleski Radek , Mróz Przemek , Skowron Jan , Szymański Michał K. , Soszyński Igor , Pietrukowicz Paweł , Kozłowski Szymon , Ulaczyk Krzysztof , Rybicki Krzysztof A. , Iwanek Patryk , Wrona Marcin , Gromadzki Mariusz ,   The OGLE collaboration
Published: November 2023

Abstract
We report on the discovery and analysis of the planetary microlensing event OGLE-2019-BLG-1180 with a planet-to-star mass ratio q ∼ 0.003. The event OGLE-2019-BLG-1180 has unambiguous cusp-passing and caustic-crossing anomalies, which were caused by a wide planetary caustic with s ≃ 2, where s is the star–planet separation in units of the angular Einstein radius θ
E. Thanks to well-covered anomalies by the Korea Micorolensing Telescope Network (KMTNet), we measure both the angular Einstein radius and the microlens parallax in spite of a relatively short event timescale of t
E = 28 days. However, because of a weak constraint on the parallax, we conduct a Bayesian analysis to estimate the physical lens parameters. We find that the lens system is a super-Jupiter-mass planet of

M

p

=

1.75

−
0.51

+
0.53

M

J

orbiting a late-type star of

M

h

=

0.55

−
0.26

+
0.27

M

⊙

at a distance

D

L

=

6.1

−
1.3

+
0.9

kpc

. The projected star–planet separation is

a

⊥

=

5.19

−
1.23

+
0.90

au

, which means that the planet orbits at about four times the snow line of the host star. Considering the relative lens–source proper motion of μ
rel = 6 mas yr−1, the lens will be separated from the source by 60 mas in 2029. At that time one can measure the lens flux from adaptive optics imaging of Keck or a next-generation 30 m class telescope. OGLE-2019-BLG-1180Lb represents a growing population of wide-orbit planets detected by KMTNet, so we also present a general investigation into prospects for further expanding the sample of such planets.