bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of Appropriate Umbilicus Position during Abdominoplasty in Male Patients
Authors: Atiyeh Bishara S. , Emsieh Saif E. , Ibrahim Amir E. , Fadul Romeu R. , Hakim Christopher R.A. , Gnaedinger Anika G. , Oneisi Ahmad K. , Chalhoub Rawad S. , Beaineh Paul T. 
Published: October 2023

Background:
Abdominoplasty techniques are well documented. The ideal position of the umbilicus has, however, received limited attention. Unfortunately, umbilicus position is not universally agreed upon in male cosmetic abdominoplasty. This study was conducted to determine the ideal umbilicus anthropometric measurements in young men, and the relationships between umbilical position and anterior trunk and torso reference points that may be applicable to intraoperative positioning. It is aimed also at investigating whether umbilicus position would be more accurately determined by considering nipple position instead of the abdominal crease, as recently proposed.

Methods:
Several anthropometric measurements of various anterior abdominal and thoracic landmarks were conducted on 60 young and middle-aged male volunteers and 30 cadavers at São Paulo city. All statistical analysis was completed using Stata software.

Results:
Of all the measured reference points, a much stronger correlation (0.513) was demonstrated between umbilicus-anterior axillary fold (U-AX) and inter-nipple (N-N) distances with a constant golden number ratio relationship (N-N = U-AX × 0.618) compared with the weak correlation of 0.034 between umbilicus-xiphisternum and umbilicus-abdominal crease. In 75% of volunteers, the calculated U-AX was within ±3 cm of actual measurement, and in 33.33% within ±1 cm.

Conclusions:
U-AX = 1.618 × N-N equation is more predictive of adequate umbilicus repositioning during abdominoplasty in male patients. Chest and abdomen of men are a single aesthetic unit. Proper positioning of the nipples and umbilicus, as well as harmonious abdominal and torso proportions are critical for an optimal final aesthetic outcome.
Comparative Analysis of a New Automatic System and Four Existing Techniques for Autologous Fat Grafting
Authors: Nelissen Xavier , Licciardi Séverine , Nizet Christophe , Delay Emmanuel , Roche Régis 
Published: October 2023

Background:
Autologous fat grafting is increasingly used worldwide and is a very attractive technique in many ways. However, treatment duration and postinjection tissue resorption remain problematic elements, which are largely related to the preparation method used. Moreover, few scientific studies objectively compare different fat preparation methods. This study analyzes the efficiency and quality of lipoaspirates prepared with a new filtration/centrifugation system (Adipure) in comparison with several existing techniques.

Methods:
Patient lipoaspirates were processed by five different techniques: decantation, centrifugation, Macrofill, Puregraft, and Adipure. Adipose tissue was evaluated in vitro for tissue resorption and oil formation, as well as in vivo after subcutaneous injections in immunodeficient mice. Adipose grafts were collected after 1 month, weighed, and analyzed by histology with a detailed scoring method.

Results:
Decanting gives inferior results to all other techniques, in terms of amount of tissue and oil in vitro, or graft weight and histological analysis in vivo. Methods using classical Coleman centrifugation (1200g), or a modified one (400g) associated with washes (Macrofill) produce very similar results, both in vitro and in vivo. Techniques using filtration systems (Puregraft and Adipure) produce less oil overall and have a higher grafting efficiency. The best results regarding grafting efficiency and oil quantity are found with the Adipure device.

Conclusions:
A combination of filtration and very low-speed centrifugation potentiates the advantages of these techniques, in terms of graft efficiency. The adipose tissue purification being done in a few minutes, in an automatic way, undoubtedly provides a strong advantage for the use of this new system.
Oncoplastic Breast Reduction: A Systematic Review of Postoperative Complications
Authors: Benedict Katherine C. , Brown Madyson I. , Berry Hunter A. , Berry Scott M. , O’Brien Robert C. , Davis Jared M. 
Published: October 2023

Background:
Breast-conserving therapy with oncoplastic reduction is a useful strategy for partial mastectomy defect reconstruction. The most recently published systematic review of oncoplastic breast reduction outcomes from 2015 showed wound dehiscence in 4.3%, hematoma in 0.9%, infection in 2.8%, and nipple necrosis in 0.9% of patients. We performed a systematic review of oncoplastic breast reduction literature, comparing outcomes and complication rates reported over the past 8 years.

Methods:
Studies describing the use of oncoplastic breast reduction and discussion of postoperative complications were included. The primary outcome assessed was the postoperative complication rate; secondary outcomes analyzed were rates of margin expansion, completion mastectomy, and delays in adjuvant therapy due to complications.

Results:
Nine articles met inclusion criteria, resulting in 1715 oncoplastic breast reduction patients. The mean rate of hematoma was 3%, nipple necrosis was 2%, dehiscence was 4%, infection was 3%, and seroma was 2%. The need for re-excision of margins occurred in 8% of patients, and completion mastectomy in 2%. Finally, delay in adjuvant treatment due to a postoperative complication occurred in 4% of patients.

Conclusions:
Oncoplastic breast reduction is an excellent option for many patients undergoing breast-conserving therapy; however, postoperative complications can delay adjuvant radiation therapy. Results of this systematic literature review over the past 8 years showed a slight increase in complication rate compared to the most recent systematic review from 2015. With increased popularity and surgeon familiarity, oncoplastic breast reduction remains a viable option for reconstruction of partial mastectomy defects despite a slight increase in complication rate.
Categorization and recommendations for outcome measures for lower limb absence by an expert panel
Authors: Kohler Friedbert , Halford Gregory R. J. , Lukin Martina , Hafner Brian J. , Boone David A. , Desmond Deirdre M. , Franchignoni Franco , Gailey Robert S. , Hagberg Kerstin , Major Matthew J. , Resnik Linda , Tan Jade M. 
Published: October 2023

Background:
Understanding the psychometric strengths and limitations of outcome measures for use with people with lower limb absence (LLA) is important for selecting measures suited to evaluating patient outcomes, answering clinical and research questions, and informing health care policy. The aim of this project was to review the current psychometric evidence on outcome measures in people with LLA to determine which measures should be included in a stakeholder consensus process.

Methods:
An expert panel was assembled, and a 3-stage review process was used to categorize outcome measures identified in a systematic literature review into 3 distinct categories (recommended for measures with better than adequate psychometric properties; recommended with qualification; and unable to recommend). Panelists were asked to individually categorize measures based on results of a systematic review of identified measures’ psychometric properties. Each measure’s final categorization was based on ≥70% agreement by all panelists.

Results:
No outcome measure attained the ≥70% consensus threshold needed to achieve a rating of “recommend.” Hence, panelists suggested combining “recommend” and “recommend with qualifications” into a single category of “recommend with qualifications.” Using this approach, consensus was reached for 59 of 60 measures. Consensus could not be reached on 1 outcome measure (socket comfort score). Thirty-six outcome measures were categorized as “unable to recommend” based on available evidence; however, 23 (12 patient-reported measures and 11 performance-based measures) demonstrated adequate psychometric properties in LLA samples and were thus rated as “recommend with qualification” by the expert panel. The panel of experts were able to recommend 23 measures for inclusion in the subsequent stakeholder review. A key strength of this process was bringing together international researchers with extensive experience in developing and/or using LLA outcome measures who could assist in identifying psychometrically sound measures to include in a subsequent stakeholder consensus process.

Conclusion:
The above categorizations represent the current state of psychometric evidence on outcome measures for people with LLA and hence may change over time as additional research becomes available. The results will be used to achieve wider consensus from clinicians, health policymakers, health clinic managers, researchers, and end users (i.e., individuals with LLA) on outcome measures for the International Society of Prosthetics and Orthotics lower limb Consensus Outcome Measures for Prosthetic and Amputation ServiceS.
3D Acoustic Wave Sparsely Activated Localization Microscopy With Phase Change Contrast Agents
Authors: Riemer Kai , Tan Qingyuan , Morse Sophie , Bau Luca , Toulemonde Matthieu , Yan Jipeng , Zhu Jingwen , Wang Bingxue , Taylor Laura , Lerendegui Marcelo , Wu Qiang , Stride Eleanor , Dunsby Christopher , Weinberg Peter D. , Tang Meng-Xing 
Published: October 2023

Objective
The aim of this study is to demonstrate 3-dimensional (3D) acoustic wave sparsely activated localization microscopy (AWSALM) of microvascular flow in vivo using phase change contrast agents (PCCAs).

Materials and Methods
Three-dimensional AWSALM using acoustically activable PCCAs was evaluated on a crossed tube microflow phantom, the kidney of New Zealand White rabbits, and the brain of C57BL/6J mice through intact skull. A mixture of C3F8 and C4F10 low-boiling-point fluorocarbon gas was used to generate PCCAs with an appropriate activation pressure. A multiplexed 8-MHz matrix array connected to a 256-channel ultrasound research platform was used for transmitting activation and imaging ultrasound pulses and recording echoes. The in vitro and in vivo echo data were subsequently beamformed and processed using a set of customized algorithms for generating 3D super-resolution ultrasound images through localizing and tracking activated contrast agents.

Results
With 3D AWSALM, the acoustic activation of PCCAs can be controlled both spatially and temporally, enabling contrast on demand and capable of revealing 3D microvascular connectivity. The spatial resolution of the 3D AWSALM images measured using Fourier shell correlation is 64 μm, presenting a 9-time improvement compared with the point spread function and 1.5 times compared with half the wavelength. Compared with the microbubble-based approach, more signals were localized in the microvasculature at similar concentrations while retaining sparsity and longer tracks in larger vessels. Transcranial imaging was demonstrated as a proof of principle of PCCA activation in the mouse brain with 3D AWSALM.

Conclusions
Three-dimensional AWSALM generates volumetric ultrasound super-resolution microvascular images in vivo with spatiotemporal selectivity and enhanced microvascular penetration.
FDG-Avid Granulomatous Lymphocytic Interstitial Lung Disease With Common Variable Immunodeficiency
Authors: van der Zant Friso M. , Knol Remco J. J. 
Published: October 2023

Abstract
A 26-year-old woman with known common variable immunodeficiency was referred for FDG PET/CT because of interstitial pulmonary abnormalities and enlarged mediastinal and hilar lymph nodes. FDG PET showed a combination of ground-glass abnormalities and pulmonary nodules, both displaying increased FDG uptake. In addition, multiple FDG-avid axillary, mediastinal, hilar, and inguinal lymph nodes were found. The abnormalities were diagnosed as granulomatous-lymphocytic interstitial lung disease. Cytology of mediastinal lymph nodes yielded only benign disease, without further specification, whereas histology of an excised axillary lymph node showed reactive changes, but no malignancy.
ECMO in Trauma Care: What You Need to Know
Authors: Flatley Meaghan , Sams Valerie G. , Biscotti Mauer , Deshpande Shyam J. , Usman Asad A. , Cannon Jeremy W. 
Published: October 2023

Abstract
Over the past ten years, extracorporeal membrane oxygenation (ECMO) use in trauma patients has increased significantly. This includes adult and pediatric trauma patients and even combat casualties. Most ECMO applications are in a venovenous (VV ECMO) configuration for acute hypoxemic respiratory failure or anatomic injuries that require pneumonectomy or extreme lung rest in a patient with insufficient respiratory reserve. In this narrative review, we summarize the most common indications for VV ECMO and other forms of ECMO support used in critically injured patients, underscore the importance of early ECMO consultation or regional referral, review the technical aspects of ECMO cannulation and management, and examine the expected outcomes for these patients. In addition, we evaluate the data where it exists to try to debunk some common myths surrounding ECMO management.
Adolescent chronic sleep restriction promotes alcohol drinking in adulthood: evidence from epidemiological and preclinical data
Authors: Faniyan Oluwatomisin O. , Marcotulli Daniele , Simayi Reyila , Del Gallo Federico , De Carlo Sara , Ficiarà Eleonora , Caramaschi Doretta , Richmond Rebecca , Franchini Daniela , Bellesi Michele , Ciccocioppo Roberto , Vivo Luisa de 
Published: October 2023

AbstractEpidemiological investigations have indicated that insufficient sleep is prevalent among adolescents, posing a globally underestimated health risk. Sleep fragmentation and sleep loss during adolescence have been linked to concurrent emotional dysregulation and an increase in impulsive, risk-taking behaviors, including a higher likelihood of substance abuse. Among the most widely used substances, alcohol stands as the primary risk factor for deaths and disability among individuals aged 15-49 worldwide. While the association between sleep loss and alcohol consumption during adolescence is well documented, the extent to which prior exposure to sleep loss in adolescence contributes to heightened alcohol use later in adulthood remains less clearly delineated.Here, we analyzed longitudinal epidemiological data spanning 9 years, from adolescence to adulthood, including 5497 participants of the Avon Longitudinal Study of Parents And Children cohort. Sleep and alcohol measures collected from interviews and questionnaires at 15 and 24 years of age were analyzed with multivariable linear regression and a cross-lagged autoregressive path model. Additionally, we employed a controlled preclinical experimental setting to investigate the causal relationship underlying the associations found in the human study and to assess comorbid behavioral alterations. Preclinical data were collected by sleep restricting Marchigian Sardinian alcohol preferring rats (msP, n=40) during adolescence and measuring voluntary alcohol drinking concurrently and in adulthood. Polysomnography was used to validate the efficacy of the sleep restriction procedure. Behavioral tests were used to assess anxiety, risky behavior, and despair.In humans, after adjusting for covariates, we found a cross-sectional association between all sleep parameters and alcohol consumption at 15 years of age but not at 24 years. Notably, alcohol consumption (Alcohol Use Disorder Identification Test for Consumption) at 24 years was predicted by insufficient sleep at 15 years whilst alcohol drinking at 15 years could not predict sleep problems at 24. In msP rats, adolescent chronic sleep restriction escalated alcohol consumption and led to increased propensity for risk-taking behavior in adolescence and adulthood.Our findings demonstrate that adolescent insufficient sleep causally contributes to higher adult alcohol consumption, potentially by promoting risky behavior.
Ischemic Stroke after Bivalent COVID-19 Vaccination: A Self-Controlled Case Series Study
Authors: Xu Stanley , Sy Lina S. , Hong Vennis , Holmquist Kimberly J. , Qian Lei , Farrington Paddy , Bruxvoort Katia J. , Klein Nicola P. , Fireman Bruce , Han Bing , Lewin Bruno J. 
Published: October 2023

AbstractIntroductionThe potential association between bivalent COVID-19 vaccination and ischemic stroke remains uncertain, despite several studies conducted thus far. The purpose is to evaluate the risk of ischemic stroke following bivalent COVID-19 vaccination.MethodsA self-controlled case series study was conducted among members aged ≥12 years who experienced ischemic stroke between September 1, 2022 and March 31, 2023 in a large California health care system. Ischemic strokes were identified using ICD-10 codes in Emergency Department and inpatient settings. Exposures were Pfizer-BioNTech or Moderna bivalent COVID-19 vaccination. Risk intervals were pre-specified as 1–21 days and 1–42 days after bivalent COVID-19 vaccination; all non-risk-interval person-time served as control interval. We conducted overall and subgroup analyses by age, history of SARS-CoV-2 infection, and co-administration of influenza vaccine. When an elevated risk was detected, we performed chart review of ischemic strokes, and re-evaluated the risk.RESULTSWith 4933 cases, we found no increased risk within 21-day risk interval across vaccines and by subgroups. However, an elevated risk emerged within 42-day risk interval among individuals <65 years who received co-administration of Pfizer-BioNTech bivalent vaccine and influenza vaccine on the same day; relative incidence (RI) was 2.14 (95% CI, 1.02–4.49). Among those who also had history of SARS-CoV-2 infection, RI was 3.94 (95% CI, 1.10–14.16). After chart review, RIs were 2.35 (95% CI, 0.98–5.65) and 4.33 (95% CI, 0.98–19.11), respectively. Among individuals <65 years who received Moderna bivalent vaccine and had history of SARS-CoV-2 infection, RI was 2.62 (95% CI, 1.13–6.03) before chart review and 2.24 (95% CI, 0.78–6.47) after chart review.CONCLUSIONSThe potential association between bivalent COVID-19 vaccination and ischemic stroke in the 1-42-day analysis warrants further investigation among individuals <65 years with influenza vaccine co-administration and prior SARS-CoV-2 infection.
Longitudinal viscosity of blood plasma for rapid COVID-19 prognostics
Authors: Illibauer Jennifer , Clodi-Seitz Tamara , Zoufaly Alexander , Aberle Judith H. , Weninger Wolfgang J. , Foedinger Manuela , Elsayad Kareem 
Published: October 2023

AbstractBlood Plasma Viscosity (PV) is an established biomarker for numerous diseases. While PV colloquially refers to theshear viscosity, there is a second viscosity component--thebulk viscosity--that describes the irreversible fluid compressibility on short time scales. The bulk viscosity is acutely sensitive to solid-like suspensions, and obtainable via the longitudinal viscosity from acoustic attenuation measurements. Whether it has diagnostic value remains unexplored yet may be pertinent given the association of diverse pathologies with the formation of plasma suspensions, such as fibrin-microstructures in COVID-19 and long-COVID. Here we show that the longitudinal PV measured using Brillouin Light Scattering (BLS) can serve as a proxy for the shear PV of blood plasma, and exhibits a temperature dependence consistent with increased suspension concentrations in severe COVID-patient plasma. Our results open a new avenue for PV diagnostics based on the longitudinal PV, and show that BLS can provide a means for its clinical implementation.
Socioeconomic Factors Influencing Breastfeeding Duration in Bangladesh:An Analysis of the Bangladesh Demographic and Health Survey
Authors: Alam Bashirul , Rony Mohammad Abu Tareq , Islam Md Aminul , Hasan Md Khalid , Khan Kanamik Kani 
Published: October 2023

AbstractBackgroundThis cross-sectional survey aimed to investigate the socioeconomic factors influencing the Duration of Breastfeeding in Bangladesh, using data from the Bangladesh Demographic and Health Survey (BDHS) 2017-18, with a sample of 4,881 mothers having children under two years old. The mean Duration of exclusive Breastfeeding was 15.23 months, with a standard deviation of 9.83 months.MethodsThe study utilized statistical tests such as independent sample t-test and one-way analysis of variance (ANOVA) to identify significant differences in the Duration of Breastfeeding between different groups. Pearson’s correlation coefficient was used to explore the linear relationship between the Duration of Breastfeeding and other continuous variables. At the same time, multinomial logistic regression analysis was employed to determine the predictors of breastfeeding duration.ResultThe study revealed significant variations in the Duration of exclusive Breastfeeding based on various demographic, health-related, socioeconomic, and anthropometric factors. Women who received antenatal care had a significantly shorter duration of exclusive breastfeeding compared to those who did not receive such care. However, no significant differences were observed in breastfeeding duration between male and female children or between those born via cesarean section versus vaginal delivery. Also, mothers who gave birth in a hospital or clinic breastfed exclusively for a shorter period than those who gave birth at home. Moreover, mothers who worked outside the house had a longer duration of exclusive Breastfeeding than homemakers.The study also noted substantial differences in exclusive breastfeeding duration based on religion and mothers’ body mass index (BMI). Women in the Barisal region breastfed exclusively for a shorter time than those in other regions. Additionally, women classified as underweight (BMI <18.5 kg/m2) breastfed exclusively longer than those with average weight or obese mothers.ConclusionPolicymakers and program implementers can use these findings to work with specific groups of mothers, mainly those less educated, residing regions, or possessing distinct health or socioeconomic characteristics, to promote optimal infant feeding practices and improve overall child health outcomes by breastfeeding practices in Bangladesh.Ethics and consentThis study does not contain personal identifiable information (PII), so ethical approval is not required. Data collection has been done by obtaining consent.
Characteristics of patients with myofascial pain syndrome of the low back
Authors: Tsai Pao-Feng , Edison Joseph L. , Wang Chih-Hsuan , Gramlich Michael W. , Manning Kailea , Deshpande Gopikrishna , Bashir Adil , Soften JoEllen 
Published: October 2023

AbstractObjectiveIdentify characteristics of patients with myofascial pain syndrome (MPS) of the low back.MethodsTwenty-five subjects with myofascial trigger point(s) [MTrP(s)] on the low back participated in this cross-sectional study. The location, number and type (active or latent) of MTrPs were verified by ultrasound; additionally, data on pain pressure threshold, physical function, quality of life, disability, pain catastrophizing, pain self-efficacy, kinesiophobia, emotional health, exercise motivation and pain were collected. Descriptive statistics, Chi-square, one-way ANOVAs and factorial ANCOVA were used to achieve study objectives.ResultsNo statistically significant differences in variables were found between types of MTrPs: Group 1 (Active, n=13), 2 (Latent, n=5) 3 (Atypical, no twitching but with spontaneous pain, n=2) and 4 (Atypical, no twitching and no spontaneous pain, n=5) except the number of MTrPs, current pain, and worst pain (p=.01-.001). There were interaction effects between spontaneous pain and twitching response on reports of physical function, current pain level, and worst pain level (p=.04-.002). Participants in Group 3 reported lower levels of physical function, higher levels of current pain, and higher levels of worst pain compared to those in Group 4. Participants in Group 1 and 2 had similar levels of physical function, current pain and worst pain.DiscussionNumber of MTrPs is most closely associated with the level of pain. Spontaneous pain report seems to be a decisive factor associated with poor physical function; however, twitching response is not.