bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of innovative wound exudates dissolvable electrospun povidone-iodine loaded poly (Ɛ-caprolactone)-poly (ethylene oxide) composite nanofiber mat based wound bandages
Authors: Tabane Tumelo H. , Batlokwa Bareki S. 
Published: November 2023

Changing of bandage when nursing chronic wounds is a necessary exercise that encourages effective wound healing but often the bandage gets stuck to the wound, making changing it painful and uncomfortable. Furthermore, most of the wound medicine that is usually smeared on the bandage gets thrown away with the removed bandage unused. To deal with these challenges, we fabricated an innovative, dissolvable, drug releasing bandage based on electrospun povidone iodine (pvpi) blended poly (Ɛ-caprolactone), PCL-poly (ethylene oxide), PEO, composite nanofiber mats. From the experiments, smooth, yellow coloured nanofiber mats of calculated average fiber diameters of 341 nm were obtained from electrospinning an optimized 80:20 (v/v) PCL: PEO composite solution, blended with an optimized quantity of pvpi acting as model medicine incorporated in the structure of the nanofiber mats. From the performance evaluation results, the electrospun composite nanofiber mats excelled in releasing over 50% of the loaded pvpi over prolonged drug release time of 210 min which compared well with 200 min we reported in our previous work. Additionally, the composite nanofiber mats proved to be hydrophilic, influenced by the incorporation of the hydrophilic pvpi and PEO within the composite mats. Furthermore, the nanofiber mats gradually dissolved in phosphate-buffered saline (PBS), that was employed as wound exudate mimic, just under 24 h qualifying them as wound exudates-dissolvable nanofiber bandages that could revolutionize the bandage history and make wound care management free from bandage changes as well as totally removing medicine wastage during bandage changing and improving medicine efficacy during wound dressing.
Keywords: Chronic wounds, Wound exudates, Electrospinning, Polymer composite nanofibers, Electrospun nanofiber bandages, Innovative drug delivery bandages, Dissolvable nanostructured bandages
EVALUATION OF THE FREE RADICAL SCAVENGING OF TECTOQUINONE COMPOUND ISOLATED FROM SYZYGIUM OBLANCEOLATUM (C.B.ROB.) MERR
Authors: Najib Ahmad , Handayani Virsa , Jaelani Muhammad Rizki 
Published: November 2023

Aim and objective: In this study, the free radical scavenging of tectoquinone compound isolated from leaf of Syzygium oblanceolatum (C.B. Rob.) Merr was investigated by assessing their capacity to scavenge free radicals using the DPPH (2, 2-diphenyl-1-picrylhydrazyl) assay.
Methods: The quantitative assessment of antioxidant activity was conducted using a UV-Vis spectrophotometric approach, with measurements taken at a wavelength of 516 nm.
Results: The IC50 value, representing the concentration required to inhibit 50% of the DPPH radicals, was determined to be 66.362 μg/mL, indicating a moderate free radical-scavenging activity.
Conclusion: These findings suggest that tectoquinone compounds possess a discernible ability to against free radical, though further research may be necessary to optimize their potential applications in health and medicine.

Peer Review History:
Received: 21 August 2023; Revised: 18 September; Accepted: 9 October, Available online: 15 November 2023
Academic Editor: Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, alyahawipharm@yahoo.com
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
EXTENT OF HEPATOTOXICITY OF ANTI-TUBERCULOSIS DRUGS USED IN PAKISTAN: A CROSS-SECTIONAL STUDY
Authors: Shahid Sara , Ahmed Fahad , Mustafa Abid , Sana Anosh , Khan Rabeel , Shahzad Seerat , Zulfiqar Ayesha , Farooq Hamza , Abbas Sameen , Razzaq Tabinda , Amjad Umair , Ali Wasiq , Saqlain Muhammad 
Published: November 2023

Introduction: Tuberculosis is an infectious disease with high rates of infection and mortality throughout the world, but its spread is greater in developing countries, and its control is difficult. It is known that the most common side reaction of drug treatment for tuberculosis is hepatotoxicity resulting from the drugs, which negatively affects adherence to treatment as a result of patients not continuing to use it.
Objective:This study aimed to determine the extent of hepatotoxicity as a result of drug treatment for tuberculosis.
Methods: The study is a cross-sectional study conducted on TB patients undergoing TB treatment in a general hospital in Islamabad, Pakistan. A data collection form was used to obtain demographic and treatment data. The hepatotoxicity of TB drug therapy was evaluated by performing liver function tests (LFTs).Study duration was of 4 months.
Results: The study showed that out of 100 tuberculosis patients, 55 patients were hepatotoxic. Hepatotoxic population includes 26% males and 29% females including almost 10% children either male or female. The maximun hepatotoxicity was observed in the patients undergoing combination therapy. Around 3-5 % patients showed that the Serum-GlutamicPyruvic-Transaminase (SGPT) values more than 2 times of their normal values. While other 50% showed hepatotoxicity 1-2 times of their normal values. Most of the patients found were in the age group ranging from 35-60 years. The main drugs used in tuberculosis treatment were: Isoniazid, Rifampicin, Pyrazinamide, Ethambutal.
Conclusion:The rate of hepatotoxicity in TB patients on anti-TB treatment was high. The current study concluded that the more we move towards a greater number of drugs in combination, the greater the extent and chance of hepatotoxicity. The combination of three anti-tuberculosis drugs (isoniazid, rifampicin, and pyrazinamide) resulted in maximum hepatotoxicity.

Peer Review History:
Received: 21 August 2023; Revised: 18 September; Accepted: 19 October, Available online: 15 November 2023
Academic Editor: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Owanaro Peter, Nigeria, Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria. owonaropeter@gmail.com
Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
Dr. Sheikh Abdul Khaliq, Department of Pharmacy Practice, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan, drwadhsheikh1974@gmail.com
MEDICINAL PROPERTIES OF RICINUS COMMUNIS AND THE NEED FOR NOVEL FORMULATION OF THE EXTRACTS: A REVIEW
Authors: Ekoja Ali , Audu-Peter Jennifer D. 
Published: November 2023

Some drugs from plant and animal sources have proven to be efficacious, safe, and effective therapeutically. They are potential alternatives to synthetic and semi-synthetic drugs in treating diseases, especially the chronic types. Ricinus communis is one such plant that has been used traditionally for centuries as a medicinal plant in the treatment of a wide range of ailments and disorders like stomach aches, flatulence, constipation, and gallbladder pain. Others include dysmenorrhea, rheumatism, arthritis, backache, muscle aches, and toothache. In addition, other uses include chronic headaches, insomnia, placenta expulsion, and anti-fertility. However, there is a deficiency of novel formulations of the extracts to maximize their therapeutic benefits. The phytochemicals in Ricinus communis are extracted via direct expression of the seed and solvent of both the seed and the different plant parts. Some solvents used for extraction include ethanol, petroleum ether, methanol, ethyl acetate, toluene, benzene, hexane, and chloroform. The constituents of the extracts depend on the plant part used, the solvent employed, and contact time. The phytochemicals found in the various extracts include tannins, saponins, phenols, alkaloids, glycosides, phytate, fatty acids, steroids, oxalate, and volatile constituents. These extracts are found to elicit a wide range of pharmacological activities against bacteria, fungi, cancer cells, worms, conception, constipation, pain, and malaria. In addition, some of the pharmacodynamic activities are laxative, uterine contraction, antiasthmatic, antidiabetic, anti-inflammatory, and anticonvulsant. The extracts are also useful in bone regeneration, wound healing, liver protection, and a host of other pharmacological actions. Novel products of Ricinus communis are not available. Subjecting the extracts to advanced drug delivery formulations such as lipid-based drug delivery technologies would accentuate the dissolution, absorption, and bioavailability of the extracts of Ricinus communis just like other herbal formulations currently in the market. Therefore, there is a crucial need for formulation scientists to explore novel nano-drug delivery technology to formulate extracts into medicines for the improvement of public healthcare.

Peer Review History:
Received: 19 August 2023; Revised: 21 September; Accepted: 24 October, Available online: 15 November 2023
Academic Editor: Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Ali Jaber, Laboratory for Research and Development of Medicines and Natural Products, RDMPN, Faculty of Pharmacy, Lebanese University, Beirut, Lebanon, ali.jaber.2@ul.edu.lb
Prof. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com
What Does the Auditor Say? Auditors’ Disclosures of Critical Audit Matters and Audit Fees
Authors: Chen Jeff Zeyun , Nelson Karen K. , Wang Yanyan , Yu Lisheng 
Published: November 2023

SYNOPSIS
We examine whether critical audit matter (CAM) disclosures contain information about material misstatement risks that is priced in audit fees. We find that textual features of auditors’ risk descriptions and the types of risks identified capture fee-relevant information. Further, the results are incremental to other determinants of audit fees considered in prior research and to managements’ disclosures in the related notes to the financial statements. Overall, we provide evidence that auditors’ perceptions of audit risks revealed in the newly expanded audit opinion capture information relevant for understanding audit pricing decisions.
Data Availability: All data are publicly available from the sources identified in the paper.
JEL Classifications: M41; M42; M48.
PENGEMBANGAN INOVASI PANGAN LOKAL PADA PEMBUATAN TEPUNG JAMUR TIRAM DI KELOMPOK TANI HUTAN MEKAR HASANAH LEBAK-BANTEN
Authors: Agustina Sri , Pitaloka Alia Badra , Pramudita Marta 
Published: November 2023

Budi daya jamur tiram (Pleurotus ostreatus) merupakan salah satu usaha pangan pertanian di kabupaten Lebak, Banten yang dikembangkan oleh Kelompok Tani Hutan dibawah pembinaan Dinas Lingkungan Hidup dan Kehutanan Provinsi Banten. Salah satunya adalah Kelompok Tani Hutan Mekar Hasanah dari kampung Cihelang, Rangkasbitung, Lebak. Jamur tiram memiliki daya simpan yang cukup rendah karena mudah mengalami kerusakan setelah dipanen.Salah satu cara untuk memperpanjang umur simpan jamur tiram adalah melalui proses pengolahan menjadi produk pangan yang baru, seperti tepung serbaguna. Melalui kegiatan pengabdian kepada masyarakat ini, masyarakat Kelompok Tani Hutan Mekar Hasanah diberikan pengarahan mengenai cara pengolahan jamur tiram menjadi tepung. Tepung yang diperoleh melalui proses pengolahan jamur tiram ini dapat digunakan dalam berbagai macam jenis makanan olahan dan memiliki nilai gizi yang baik.
PELATIHAN PERAWATAN ZONA LAMBUNG PERAHU IKAN BERBAHANKAYU BAGI KELOMPOK NELAYAN DESA LONTAR KECAMATAN TIRTAYASA KABUPATEN SERANG
Authors: Marasabessy Amir , Sudjasta Bambang , Rhakasywi Damora 
Published: November 2023

Pengabdian kepada masyarakat sangat membantu bagi kehidupan masyarakat untuk memperbaiki taraf kehidupan perekonomian agar bisa menjadi sejahtera. Kehidupan masyarakat Desa Lontar lebih didominasi oleh mitra kelompok nelayan dengan jumlah 1327 orang dan petani rumput laut 1021 orang. Hasil produksi penangkapan ikan dapat dikatakan belum maksimal jika dibandingkan dengan luas perairan 11.134,224 Km2 dan panjang garis pantai 517,42 Km. Saat ini mata pencaharian masyarakat Desa Lontar sebagian besar sebagai nelayan yang setiap hari mencari ikan untuk memenuhi kebutuhan hidup, perahu ikan yang digunakan berbahan kayu dengan kondisi phisik 40-50 % telah mengalami degradasi, dengan jumlah perahu ikan ± 100 unit. Aspek penting yang mendapat perhatian adalah sebagian besar perahu ikan tidak melaut karena sering terjadi kerusakan/kebocoran zona lambung ± 3 – 4 kali dalam setahun. Tujuan pelaksanaan PKM adalah memberikan pelatihan perawatan zona lambung perahu ikan berbahan kayu menggunakan bahan fiberglass. Metode yang digunakan adalah pendampingan pelatihan dengan melibatkan mitra kelompok nelayan, sebagai upaya transfer ilmu dan teknologi perawatan zona lambung perahu ikan berbahan kayu secara aplikatif. Hasil dari kegiatan Program Kemitraan Masyarakat, mitra kelompok nelayan dapat melakukan perawatan zona lambung perahu ikan secara mandir/kelompoki untuk menghindari kerusakan/kebocoran dan mempertahankan kekuatan zona lambung guna kelancaran dan keselamatan mencari ikan di laut.
BETERNAK DENGAN SUMBER AIR TERDEKAT UNTUK MENINGKATKAN USAHA DI DESA BERNUNG KECAMATAN GEDONG TATAAN PESAWARAN LAMPUNG
Authors: Dewanto Ordas , Irawan Bambang , Wibowo Rahmat Catur 
Published: November 2023

Sebelah timur Kecamatan Gedong Tataan Kabupaten Pesawaran terletak Desa Bernung. Ada masalah mitra yang timbul pada proses berternak, yaitu masalah kebutuhan air. Belum adanya air yang cukup menyebabkan kolam ikan airnya berkurang dan jarang diganti. Masalah berikutnya yaitu saat musim kemarau panjang, menyebabkan berkurangnya air, sehingga kolam ikan mengalami kekeringan. Metode yang digunakan adalah melalui penyuluhan, pelatihan dan demonstrasi serta evaluasi untuk melihat efektivitas program sehingga program akan tersosialisasi dengan baik serta efisien. Metode lainnya meliputi desain pembuatan alat saluran air dan tempat usaha, demonstrasi dan pelatihan. Mata air terdekat Desa Bernung dapat dimanfaatkan untuk peningkatan usaha peternak dengan cara membuat desain saluran air terdekat. Selanjutnya untuk menghadapi musim kemarau perlu membuat sumur dengan cara menentukan kedalaman air tanah menggunakan metode Geolistrik. Hasil akhir yang diperoleh adalah: Terimplementasinya desain pemanfaatan air dari sumber air terdekat menuju tempat mitra, termasuk desain saluran air di tempat ternak dan rumah tangga; telah dilaksanakan penentuan kedalaman air tanah menggunakan metode Geolistrik; Pembuatan kolam ikan sebagai usaha kelompok peternak agar panen peternakan meningkat. Kemudian menyebarkan bibit ikan dan ternak lain dengan tujuan meningkatkan usaha.
PERENCANAAN MASTER PLAN KAWASAN AGROWISATA PESANTREN WIHDATUL ULUM DI KECAMATAN PARANGLOE KABUPATEN GOWA
Authors: Zaki Muhammad , Yudistira Adithya 
Published: November 2023

Pesantren merupakan lembaga pendidikan Tertua dalam sejarah nasional yang hingga kini masih merupakan aset bangsa yang cukup mengakar dalam kehidupan masyarakat. Cakupan kegiatan pondok pesantren semakin luas dan mendalam, kegiatan tidak lagi terbatas pada pendidikan agama, dakwah, pembinaan umat dan kegiatan sosial lainnya, tetapi juga telah merambah pada kegiatan ekonomi. Agrowisata merupakan salah satu bentuk ekonomi kreatif di sektor pertanian yang dapat memberikan nilai tambah agrobisnis dalam rangka peningkatan kesejahteraan petani. Yayasan Wakaf UMI Pesantren Wihdatul Ulum adalah pondok pesantren yang memiliki luas lahan 6.4621 Ha dan yang baru termanfaatkan sekitar 2 Ha. Potensi lahan yang belum termanfaatkan dan teraksimalkan ini, perlu dikelola dengan tepat menjadi andalan dalam peningkatan perekonomian di lingkungan pesantren wihdatul ulum kabupaten gowa. kegaiatan Pengabdian masyarakat ini kami merencanakan Masterplan Agrowisata yang nantinya diisi oleh fasilitas-fasilitas yang menunjang segala bentuk kegiatan berdasarkan fungsi Agrowisata tersebut.
Virtual Reality Warisan Sejarah Lampung: Pengalaman Interaktif dan Edukatif di Desa Negeri Katon
Authors: Muhammad Meizano Ardhi , Pratama Mahendra , Utaminingtyas Ika Wulandari , Sulistiono Wahyu Eko , Martinus  , Djausal Gita Paramita , Mardiana  , Herlinawati  , Despa Dikpride , Khotimah Siti Nurul 
Published: November 2023

Virtual Reality Warisan Sejarah Lampung (VRWSL) dikembangkan untuk meningkatkan pengetahuan masyarakat Lampung tentang sejarah Lampung. Teknologi Virtual Reality (VR) memberikan pengalaman interaktif dan akses informasi sejarah. VRWSL memfasilitasi diseminasi sejarah Lampung melalui model interaktif dan mendalam, melewati batasan spasial dan temporal. Desa Negeri Katon Kabupaten Pesawaran, yang terkenal dengan warisan budayanya, menjadi target dalam program pengabdian kepada masyarakat. VRWSL menawarkan pengalaman Virtual Reality yang memungkinkan pengguna untuk mengunjungi secara virtual situs-situs bersejarah dan mengakses informasi terkait. Delapan landmark, termasuk Museum Lampung, Vihara Thay Hin Bio, dan Monumen Krakatau, dihadirkan dalam aplikasi ini. Implementasi VRWSL meliputi penggunaan model 3D berkepadatan rendah (low-polygon) dan foto 360 derajat yang memberikan pengalaman yang mendalam. Uji Penerimaan Pengguna (User Acceptance Test) dilakukan untuk mengevaluasi efektivitas, efisiensi, dan kepuasan pengguna terhadap VRWSL. Hasil evaluasi menunjukkan bahwa mayoritas pengguna (60,94%) sangat setuju bahwa VRWSL merupakan media yang efektif untuk mempelajari budaya dan sejarah Lampung. Pengembangan VRWSL yang sukses menggambarkan potensinya dalam mempromosikan pelestarian budaya dan mendiseminasi sejarah Lampung. Aplikasi ini memberikan cara yang mudah bagi individu untuk menjelajahi warisan Lampung tanpa perlu melakukan perjalanan fisik, sehingga memperkaya pengalaman budaya dan berkontribusi dalam pelestarian sejarah Lampung.
Smartphone addiction and life satisfaction: mediating effect of negative emotions
Authors: Vallejos-Flores Miguel Angel , Talledo-Sánchez Karim , Carlos-Ventura David , Sullcahuaman Amésquita Jessica J , Caycho-Caja Aaron , Vigo-Carbajal Abigail 
Published: November 2023

Background: Smartphone users have increased worldwide, due to their multifunctionality and accessibility. Objective: To determine the mediating effect of negative emotions between life satisfaction and smartphone addiction in college students. Method: A structural equation explanatory model was proposed in which each negative emotion (depression, anxiety, and stress) has a mediating role between life satisfaction and cell phone addiction. To this end, 1109 university students from Metropolitan Lima were selected and administered the DASS 21, SABAS, SWLS. Result: A partial effect of each mediating model was found, in addition to Satisfaction with life achieved a direct effect on cell phone addiction; at the same time the mediating variables achieved a significant direct effect on addictive behavior. Conclusion: Negative emotions have a mediating role in explaining smartphone addiction.
Catalogue-based spatio-temporal analysis and evaluation of seismic scenarios in the Talysh zone (Azerbaijan)
Authors: Aliyev Y.N. , Babayev G.R. 
Published: November 2023

In this paper, we simulate ground motion shaking of the Talysh zone based on the hybrid stochastic-deterministic approach using catalogue-based spatiotemporal analysis for 1970—2019 from the various local and international sources and the fault source pattern. Data for a homogenous and reliable catalogue are obtained from the International Seismological Center (ISC), European Mediterranean Seismological Center, National Earthquake Information Center, and Republican Center of Seismological Survey at the Azerbaijan National Academy of Science. To evaluate the ground shaking and to characterize its spatial variability, an intensity map was plotted depending on the selected seven active faults and lineaments tracing in the Talysh zone, considering the location, size and length of faults, using empirical relations between magnitude and intensity. The mapping results are presented in terms of intensity distribution. The plotted map shows that shakings with an intensity of VII are observed mainly in the central and western parts of the zone and are predicted to be the highest in the study area. The ground shaking with an intensity VI covers most of the Talysh zone. The magnitude computation results show that a maximum earthquake with Mw=6.2 can be generated by the West Caspian fault.
This study applied various seismic input parameters and different approaches to give the basic information to evaluate the range of intensity distribution in seismic scenarios. The results will contribute to implementing more solid analyses for advancing earthquake countermeasure plans and seismic hazard analysis.