bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between apoptosis markers and the severity of coronary atherosclerosis and clinical and paraclinical characteristics of patients with coronary artery disease
Authors: Zakharyan E. A , Fomochkina I. I 
Published: November 2023

Aim. To assess markers of serum apoptosis markers depending on the severity of coronary atherosclerosis, as well as to study their relationship with clinical and paraclinical characteristics of patients with coronary artery disease (CAD).Material and methods. The study included 176 people (105 men and 71 women), of which 150 were patients with an established diagnosis of CAD, 26 — healthy volunteers (control group). The patients were divided into the following groups: group 1 — with coronary atherosclerosis without stenosis (n=17); group 2 — with hemodynamically insignificant (stenosis <50%) coronary atherosclerosis (n=21); group 3 — with hemodynamically significant (stenosis >50%) coronary atherosclerosis (n=112). Group 4 was represented by healthy volunteers (n=26). Patients underwent coronary angiography using the SYNTAX score, echocardiography, extracranial artery duplex ultrasound. All subjects were studied for the serum level of apoptosis markers Bcl-2, Bax, Bcl-2/Bax, TRAIL and p53. Statistical processing was carried out using the Statistica 10.0 software. Differences were considered significant at p<0,05.Results. There was a very high correlation between the Bcl-2 (r=-0,84; p<0,001), Bax (r=0,83; p<0,001), Bcl-2/Bax (r=-0,86; p<0,001), p53 (r=0,80; p<0,001), TRAIL (r=-0,78; p<0,001) and the severity of coronary atherosclerosis. A correlation of varying strength and significance was revealed between the values of these apoptosis markers and a number of clinical and paraclinical characteristics of patients. In addition, there were significant differences (p<0,001) in Bcl-2, Bax, Bcl2/Bax, p53 and TRAIL between groups of patients with multifocal atherosclerosis, restenosis after previous revascularization and a history of myocardial infarction in comparison with patients without these signs.Conclusion. The correlations we have identified between laboratory signs of apoptosis and coronary lesions, clinical and paraclinical characteristics of patients, as well as the detected reliability of differences between groups with multifocal atherosclerosis, coronary artery restenosis and myocardial infarction in history, make it possible to consider these biomarkers as indicators of atherosclerosis severity. This can also be the basis for the development of novel treatment and diagnostic strategies.
Machine learning in assessing the association between the size and structure of the ascending aortic wall in patients with aortic dilatation of varying severity
Authors: Uspenskiy V. E. , Saprankov V. L. , Mazin V. I. , Zavarzina D. G. , Malashicheva A. B. , Irtyuga O. B. , Moiseeva O. M. , Gordeev M. L. 
Published: November 2023

Aim. To assess the association between pathological ascending aortic (AA) wall changes and its planimetric characteristics in non-syndromic non-familial (sporadic) aneurysm and dilation of the AA.Material and methods. The study included 174 patients with sporadic aneurysms and dilation of the AA, who underwent elective surgery between January 2010 and July 2015 and were divided into 2 groups: patients with AA aneurysm (AAA) (AA diameter >50 mm) and tricuspid aortic valve (AV) with significant aortic stenosis (AS) or regurgitation (AR) (AAA group, n=120), and persons with borderline AA dilatation (AA diameter 45-50 mm), associated with a bicuspid aortic valve (BAV) and significant AS (BD group, n=54). Standard paraclinical investigations and pathological examination of the VA wall were used. Statistical processing was carried out in the SPYDER 4.1.5 environment (Python 3.8), and included univariate correlation analysis, logistic regression analysis, as well as supervised machine learning (ML) methods (support vector machine, k-nearest neighbor method, random forest).Results. Logistic regression revealed positive associations between AA atherosclerosis and age, cystic medial necrosis (CMN) and sinus of Valsalva (SV) diameters. The support vector machine method demonstrated a tendency towards AA expansion at the SV level in individuals with CMN (accuracy, 60,5%), as well as towards expansion of the tubular AA in atherosclerosis (accuracy, 79,2%). During the random forest analysis, the first stage was to construct decision trees to predict three following outcomes: the presence of CMN, atherosclerosis, or normal aortic structure. The model accuracy was 64,2%. Next, the variables "CMN" and "atherosclerosis" were combined, and prediction was made for the outcomes "normal AA wall structure" and "pathological AA wall structure". The model accuracy was 73,5%.Conclusion. The use of ML opens up new opportunities for predicting aortopathy and a patient-centered approach to treatment. In AR, a more aggressive AA intervention is warranted. To predict aortopathies, thoracic aorta diameters indexed to body surface area should not be used. Aortic wall sampling (circular section) followed by a continuous pathological examination may be promising.
Prevalence of myocarditis and its contribution to the course of primary myocardial hypertrophy
Authors: Lutokhina Yu. A. , Blagova O. V. , Kogan E. A. , Nartov A. A. , Nartova V. R. , Zaklyazminskaya E. V. , Dzemeshkevich S. L. 
Published: November 2023

Aim. To assess the incidence of myocarditis in patients with primary myocardial hypertrophy and to study its contribution to the disease course.Material and methods. The study included 100 patients with primary left ventricular myocardial hypertrophy, 52 men and 48 women (mean age, 51,5±15,7 years; followup period 10,4 [2,1; 36,1] months). All patients underwent electrocardiography, 24-hour electrocardiographic monitoring, echocardiography, as well as DNA analysis (n=96), myocardium pathological study (n=29), cardiac magnetic resonance imaging (n=31), cardiac multislice computed tomography (n=26), assessment of anti-cardiac antibodies (n=43), free light chain level in serum and urine by immunofixation method (n=10); 99mTc-pyrophosphate myocardial scintigraphy (n=5); biopsy of the rectal mucosa and/or subcutaneous fat for amyloid (n=9).Results. In 68%, true (sarcomeric) hypertrophic cardiomyopathy (HCM) was diagnosed, in 16% — amyloidosis with cardiac involvement, in 10% — storage diseases, in 3% — neuromuscular diseases, in 2% — myocardial hypertrophy was combined with severe restriction (mixed phenotype), and in 1% — LEOPARD syndrome. Concomitant myocarditis was diagnosed in 30% of patients. In HCM, myocarditis was detected in 31% of cases. These patients had a significantly higher heart failure class (heart failure class 3 [2; 3] vs 2 [1; 3], p=0,026) and mortality (33,3% vs 6,4%, p=0,01). In amyloidosis, the incidence of myocarditis was 31,3%. In these patients, ventricular tachycardia was observed significantly more often: 80,0% vs 18,2% (p=0,036). The prevalence of concomitant myocarditis in the subgroup of storage diseases was 30%: 2 patients with Fabry disease and 1 patient with Danon disease. Of the three patients with neuromuscular diseases, myocarditis was diagnosed in 1. In the subgroups with the restrictive phenotype and LEOPARD syndrome, no cases of myocarditis were recorded. Treatment of myocarditis made it possible to stabilize the patients' condition.Conclusion. Concomitant myocarditis led to heart failure progression, worsening ventricular arrhythmias and, as a consequence, an increased risk of sudden cardiac death. It is necessary to actively diagnose and treat myocarditis in patients with primary myocardial hypertrophy.
Assessment of chronic stress in the adult population of the Vladimir region
Authors: Mamedov M. N. , Sushkova L. T. , Isakov R. V. , Kutsenko V. A. , Drapkina O. M. 
Published: November 2023

Aim. To assess the prevalence of chronic stress in the adult population in the Vladimir region, taking into account sex characteristics.Material and methods. This cross-sectional population study was performed in five cities of the Vladimir Oblast (Vladimir, Kovrov, Murom, Yuryev-Polsky and Vyazniki) from May 2018 to March 2020. From six health care facilities, 9 therapeutic areas were selected. Then, from the assigned population aged 30-69 years, respondents from each area were invited to the study. To identify chronic stress, the Reeder questionnaire was used, which makes it possible to identify three types of disorders: low, moderate and severe stress. The study analyzed fully completed Reeder L. chronic stress questionnaires from 1081 respondents (393 men and 688 women).Results. Among men, every second person has a low chronic stress, 42% — moderate stress, while high chronic stress was found in 6.4% of cases. A similar trend is observed among women. High levels of chronic stress were detected in 8% of women, and the gap between the prevalence of low and moderate chronic stress was minimal. In general, the prevalence of various levels of chronic stress between men and women was comparable, without significant differences. Sex variability in the prevalence of chronic stress was revealed in various cities of the Vladimir Oblast. In Vladimir, the prevalence of high stress among men was three times higher than in women, while in Vyazniki and Kovrov the opposite pattern was observed. In the other two cities (Murom and Yuryev Polsky), the prevalence of high chronic stress between men and women was comparable.Conclusion. In the working-age population, a high chronic stress level is detected in up to 10%. In some cities, there are sex differences between men and women. The mean level of chronic stress is determined in 42-43% of cases. The results obtained indicate the need for large-scale preventive measures to combat chronic stress among working-age men and women of in the Vladimir Oblast.
Clinical efficacy of a fixed-dose combination of amlodipine/indapamide/perindopril in patients with hypertension and multiple risk factors
Authors: Pirozhenko A. A. , Ryabtsev A. S. , Shlyk S. V. , Drobotya N. V. , Kaltykova V. V. 
Published: November 2023

Aim. To evaluate the antihypertensive and organ protective efficacy of the triple fixed-dose combination of amlodipine/indapamide/perindopril in patients with hypertension (HTN) who did not achieve target blood pressure (BP) on previous antihypertensive therapy (AHT).Material and methods. The study included 47 patients with HTN and multiple risk factors who did not achieve target blood pressure during previous AHT. They were prescribed triple fixed-dose combination of amlodipine/indapamide/perindopril with preliminary prescription of amlodipine, indapamide and perindopril in the free-dose combination. At baseline and after 3 months of AHT, 24-hour ambulatory blood pressure monitoring (ABPM), echocardiography and arterial stiffness were analyzed.Results. Initially, in patients included in the study, the main ABPM parameters were increased, while non dipper and reduced dipper (66% of patients) patterns prevailed. The results of echocardiography indicated left ventricular (LV) hypertrophy (LVH) by left ventricular mass index (LVMI), left ventricular posterior wall thickness (LVPWT), interventricular septum (IVS) and its diastolic dysfunction by E/A, while an increase in CAVI and biological vascular age reflected an increase in arterial stiffness. After 3 months of AHT, significant (p£0,05) ABPM changes and a predominance of the dipper-type 24-hour BP pattern were recorded in more than half of the patients (53%). A decrease in LVMI, LVPWT and IVS by 7%, 12% and 8%, respectively (p£0,05), while an E/A increase by 12% reflected LVH regression and LV diastolic function improvement. A decrease in arterial stiffness was evidenced by a decrease (p£0,05) in CAVI by an average of 10% and biological vascular age by 4 years.Conclusion. Triple fixed-dose therapy of amlodipine/indapamide/perindopril after 3-month treatment made it possible to achieve target blood pressure in 78% of patients, improved ABPM parameters and ensured pronounced cardioand vasoprotective effects, reflected in LVH regression, improvement of LV diastolic function and reduction of arterial stiffness.
Comparative characteristics of lifestyle, office and ambulatory blood pressure among students from Tropical Africa, India and Russia
Authors: Mangileva T. A. 
Published: November 2023

Aim. To study the dependence of office and ambulatory blood pressure (BP) level in students with their ethnicity.Material and methods. A total of 110 students were examined as follows: 35 from Russia, 34 from Tropical Africa and 41 from India. Lifestyle was studied using a standardized questionnaire. All students underwent measurement of office blood pressure and 24-hour ambulatory blood pressure monitoring (ABPM) using the BPLabH system (Russia).Results. Students from Russia were more likely to lead a sedentary lifestyle than from Africa (p=0,001) or India (p=0,027). Students from Tropical Africa added salt to food more often than Indians (p=0,03). Office blood pressure measured in the first half of the day was within the normal range for all subjects and did not differ between different ethnic groups. According to ABPM, there were no intergroup differences in systolic blood pressure during the daytime and 24 hours. Diastolic blood pressure of Africans during the daytime (p=0,029) and 24 hours (p=0,002) was higher than in Russians. Nighttime systolic and diastolic blood pressure of African students was significantly higher than in Russian (p=0,006 and p<0,0001, respectively) or Indians (p=0,008 and p=0,006, respectively). Africans showed a smaller blood pressure decrease at night and were more likely to have masked hypertension at night than Russians (p=0,004) or Indians (p=0,046).Conclusion. Office BP did not vary by ethnicity. With ABPM, no differences in blood pressure levels were found between Indian and Russian students. African students had higher blood pressure at night, including masked hypertension, than students from India or Russia.
Comparison of methods for cardiac interoception self-assessment
Authors: Minenko I. A. , Germanova K. N. , Limonova A. S. , Sukmanova A. A. , Iashvili N. , Nikulin V. V. , Kutsenko V. A. , Egorenkova Е. E. , Nazarova M. A. , Ershova A. I. , Drapkina O. M. 
Published: November 2023

Aim. Interoception reflects the perception, integration and modulation of visceral signals. Currently, there is no established universal approach to cardiac interoception assessment allowing its inclusion in the diagnostic protocol for various diseases. The aim was to compare three tests of interoception self-assessment based on heart palpitations within one day in healthy subjects.Material and methods. Eighty healthy volunteers took part in the study. To assess cardiac interoception, a test with button pushes at the moment of palpitations, a feedback test in the form of synchronous and asynchronous sound signals, a heartbeat counting task at specified time intervals were conducted with simultaneous electrocardiographic recording. The obtained data were compared with each other (Wilcoxon test). Its pairwise dependence (Spearman coefficient) and dependence on body parameters (sex, age, body mass index, fat mass, anxiety) were assessed (univariate linear regression).Results. The accuracy of the heartbeat counting task turned out to be significantly higher than in the button- pressing test (p=0,005). However, both estimates correlate with each other (r=0,66, p=0,003). A positive dependence of test accuracy on sex was found for the heartbeat counting task (p=0,021) and a negative dependence on fat mass for button- pressing task (p=0,032).Conclusion. The study found that volunteers' estimates of heartbeat accuracy varied across tests and were also associated with sex and body composition. The heart rate counting task and the button- pressing task are the most suitable for interoception assessment.
Balancing on the redline: a qualitative study of the experiences purchasing sugar-sweetened beverages among Indigenous adults in a Canadian urban neighbourhood
Authors: Kisselgoff Maria , Champagne Michael Redhead , Dubois Riel , Turnbull Lorna , LaPlante Jeff , Schultz Annette , Bombak Andrea , Riediger Natalie 
Published: November 2023

Abstract
Objective
Growing evidence suggests that inner-city residents actively navigate their food landscape to meet a wide range of socio-economic needs. Given the increasing focus of health policies on sugar-sweetened beverages (SSB) through price-based strategies, it is critical to understand purchasing habits of populations with higher SSB intake. This study examined urban Indigenous adults’ SSB shopping behaviour and experiences.

Methods
We conducted a community-based participatory research study using semi-structured interviews with a purposive sample of Indigenous adults (≥ 18 years old) from the North End neighbourhood of Winnipeg. Interviews were audio recorded, transcribed verbatim, and thematically analyzed.

Results
All 20 participants (women = 10; men = 8; two-spirit = 2) consumed SSB on a regular, daily basis either at the time of the interview or at a prior period in their lives. Themes defining residents’ SSB shopping behaviour and experiences of shopping for SSB included balancing on the redline, specifically (1) balancing SSB purchasing constraints and facilitators with savvy shopping approaches and (2) balancing (stereo)typical reactions with resilient coping approaches. Residents procured SSB in various stores within and beyond the boundaries of the North End neighbourhood. SSB is a considerable, reoccurring expense, requiring savvy price-shopping strategies in order to access. Indigenous adults experience judgement and stereotyping when purchasing SSB, including intersecting racial, class, and weight stigma.

Conclusion
Purchasing SSB is perceived as a source of judgement when outside of inner-city neighbourhoods. Policymakers should consider how policies directed at SSB, which are consumed by Indigenous and food-insecure populations in greater quantities, may magnify existing racial, class, and weight-based discrimination.
EKSPLORASI DIMENSI PRAKTIK RELIGIUS REMAJA MUSLIM INDONESIA
Authors: Ihsan Helli , Chotidjah Sitti , , Herlina 
Published: November 2023

The concept of Christian-Western religious practice maybe different to the Islamic religious practice of Moslems. Therefore, explores the dimensions of Daily Religious Practices of Moslems (Praktik Religius Harian Muslim) (Herlina et al., 2015) consisting of 10 items that proven able to predict juvenile delinquency is important to do. This measure was assumed to be unidimensional because is just intended to measure dimensions of religious practice. Principal Component Analysis is used to find dimensions or factors of this measure. The participants were 643 students of two public high schools, one private high school, one private Islamic High School, and one Islamic boarding high school. There were two practical dimensions that found in this PRHM scale, Obligatory Practice and Sunnah Practice. These results give different concept from Western religious theory which emphasizes public and private practices. Although Moslems practices can be private and public but the practices of Indonesian Moslems teenagers were patterned to two of this dimensions.AbstrakKonsep religiusitas Barat yang berbasis Kristen mungkin saja akan berbeda dengan religiusitas Indonesia yang berdasarkan Islam. Untuk itu mengekplorasi dimensi dalam alat ukur Praktik Religius Harian Muslim (PRHM) (Herlina dkk., 2015) yang terdiri dari 10 item dan yang terbukti mampu memprediksi kenakalan remaja ini penting untuk dilakukan. Metode Principal Component Analysis digunakan untuk menemukan dimensi atau faktor yang ada dalam alat ukur ini. Partisipan yang terlibat berjumlah 643 siswa dari dua SMA Negeri, satu SMA swasta umum, satu SMA Islam, dan satu SMA Islamboarding school atau pesantren. Ada dua dimensi praktik yang ditemukan dalam alat ukur PRHM ini yaitu Ibadah Wajib dan Ibadah Sunnah. Meskipun praktik muslim bisa bersifat privat dan publik tapi praktik remaja muslim Indonesia lebih berpola kepada Ibadah Wajib dan Ibadah Sunnah.
FAKTOR YANG MEMPENGARUHI KESEJAHTERAAN SUBYEKTIF ANAK DIDIK LEMBAGA PEMBINAAN KHUSUS ANAK
Authors: Maslihah Sri 
Published: November 2023

The purpose of this study is to explore the factors of Subjective Well-Being of students of LPKA. The research used two approach with participants from LPKA Tangerang and LPKA Bandung. In the first research, 90 students filled the questionnaire and the second was qualitative method by Focus Group Discussion (FGD) technique. FDG was performed to 40 juvenille offenders (ABH) that had high subjective well-being. The result were that the factors that affect subjective well-being were the ability of children to cope stressfull situation, ability to adjust in difficult situations, spirituality and social support from family, peers and officers. Based on the results, the researchers concluded the factors that affect subjective well-being of LPKA students includes internal and external factors.AbstrakTujuan penelitian ini adalah menggali faktor-faktor yang mempengaruhi kesejahteraan subyektif anak didik LPKA. Penelitian dilakukan dua tahap dengan partisipan dari LPKA Pria Tangerang dan LPKA Bandung. Tahap pertama dilakukan dengan menyebarkan angket kepada 90 anak didik LPKA dan tahap kedua dilakukan metode kualitatif dengan menggunakan teknik pengambilan data dengan Focus Group Discussion (FGD). FDG dilakukan kepada 40 orang anak berkonflik dengan hukum (ABH) yang tingkat kesejahteraaan subyektifnya tergolong tinggi. Hasil penelitian menunjukkan bahwa faktor-faktor yang mempengaruhi kesejahteraan subyektif anak didik ini antara lain kemampuan anak untuk mengatasi situasi stressfull, kemampuan menyesuaikan diri dalam situasi sulit, spiritualitas dan dukungan sosial yang bersumber dari keluarga, teman sebaya dan petugas lembaga pembinaan khusus anak. Berdasarkan hasil tersebut peneliti menyimpulkan faktor-faktor yang mempengaruhi kesejahteraan subyektif anak didik LPKA meliputi faktor internal yang bersumber dari dalam diri anak dan faktor eksternal yang bersumber dari lingkungan.
PENERAPAN INTERVENSI SOCIAL STORY DAN ROLEPLAY UNTUK MENINGKATKAN KOMPETENSI SOSIAL PADA REMAJA DENGAN AUTISM SEPCTRUM DISORDER
Authors: Yovita Marcellina , Tjakrawiralaksana Mita Aswanti 
Published: November 2023

Abstract This research is aimed to investigate the effect of Social Story intervention combined with roleplay to increase social competence, such as social understanding and social skill on a teenager with Autism Spectrum Disorder (ASD). The design of this research is single subject design, with a 14-year-old teenage boy with ASD as a participant. Social understanding was measured by answers from the participant on social story worksheet, whereas social skill was measured qualitatively observed during roleplay and on natural settings. The results showed that the implementation of Social Story combined with roleplay improves the social competence, cognitively (social understanding) and behaviourally (social skill) on a teenager with ASD. AbstrakPenelitian ini bertujuan untuk mengetahui efek dari intervensi yang menerapkan Social Story dan roleplay untuk mengembangkan kompetensi sosial yang terdiri atas pamahaman sosial dan keterampilan sosial pada remaja dengan Autism Spectrum Disorder (ASD). Desain penelitian ini adalah single-subject design, dengan seorang remaja laki-laki berusia 14 tahun tahun yang didiagnosa memiliki ASD sebagai partisipan. Pemahaman sosial secara kognitif diperoleh dari jawaban partisipan pada lembar kerja Social Story. Sedangkan dari ranah perilaku, pemahaman sosial tercermin dari perilaku yang ditampilkan saat roleplay dan di situasi alamiah. Hasil penelitian menunjukkan bahwa penerapan Social Story dan roleplay berhasil meningkatkan kompetensi sosial, baik secara kognitif (pemahaman sosial) maupun secara perilaku (keterampilan sosial) pada remaja dengan ASD.