bluuebunny/crossref_metadata_2025_split huggingface dataset:
The evaluation of four nano-formulations loaded-Elsinochrome A on characteristics and in vitro cytotoxicity effect
Authors: Yao Yuanyuan , Wu Tianlong , Pan Lili , Yan Shuzhen , Yu Shuqin , Chen Shuanglin 
Published: December 2023

Elsinochrome A (EA) is a naturally occurring photosensitizer with potential applications in photodynamic therapy (PDT) for various malignancies. Despite its promising therapeutic properties, the poor solubility of EA hampers its effective utilization in clinical settings. To circumvent this limitation, we engineered four distinct nano-formulations: PLGA/EA nanoparticles (NPs), CMC-PLGA/EA NPs, mPEG-PCL/EA nanomicelles (NMs), and LHP-CHOL/EA nanoliposomes (NLs), all designed to enhance the solubility of EA. A comparative evaluation of these formulations, based on metrics such as particle size, Zeta potential, drug loading efficiency, and encapsulation efficiency, identified PLGA/EA NPs and mPEG-PCL/EA NMs as the most efficacious candidates. Subsequent in vitro investigations into the drug release kinetics under varying pH conditions and the impact on cell viability and apoptosis in A549 and MCF-7 cell lines were conducted. Remarkably, the maximum drug release for PLGA/EA NPs and mPEG-PCL/EA NMs was recorded at 62.5% and 70.8% in an acidic environment (pH 5.7), respectively. Upon exposure to 460 nm light, PLGA/EA NPs induced a significant reduction in A549 cell viability to 13.8% and an apoptosis rate of 93.8%, whereas mPEG-PCL/EA NMs elicited a decrease in MCF-7 cell viability to 12.8% and an apoptosis rate of 73.0%.
Increased expression of neutrophil CD15 correlates with the severity of anterior ocular surface damage in type II diabetes mellitus
Authors: Zhmud Tetiana , Barabino Stefano , Malachkova Nataliia 
Published: December 2023

Background Diabetes mellitus is associated with increased risk of ocular surface diseases in elderly. We consider neutrophil CD15 as a potential marker of ocular surface damage in type II diabetes mellitus patients Aim We aimed to evaluate expression of neutrophil CD15 and correlate it with results of conjunctival impression cytology and routine objective anterior ocular surface tests (TMH, NIBUT, LLT, MGD) in T2DM patients. Materials and methods We prospectively enrolled sixty type II diabetes mellitus patients (120 eyes) into a study group. The control group included forty (80 eyes) age- and sex-matched healthy individuals. All patients underwent comprehensive ophthalmological examination, and tear meniscus height test (TMH), noninvasive tear break-up time (NIBUT), lipid layer thickness measurement (LLT), Meibomian gland dysfunction evaluation (MGD), conjunctival impression cytology (CIC) and expression of CD15. Results Abnormal Nelson's grades of squamous metaplasia (grades 2 and 3) were observed in 50% (60 eyes) of the study group, and 13.8 (11 eyes) of the control group. Fifteen patients with type II diabetes mellitus suffered from grade 3 squamous metaplasia. Nelson's grades of squamous metaplasia have shown a positive correlation with the level of CD15 expression either in the study and control groups (rs = 0.628, p = <0.0001; rs = 0.746, p < 0.0001; respectively). Conclusions The research shows significantly reduced values of routine objective ocular tests in type II diabetes mellitus patients in comparison to healthy participants older than 60 y.o. Increased CD15 in the peripheral blood is associated with the development of squamous metaplasia and may be used to evaluate the severity of ocular surface damage in type II diabetes mellitus patients.
Is parent education a factor in identifying autism/takiwātanga in an ethnic cohort of Pacific children in Aotearoa, New Zealand? A national cross-sectional study using linked administrative data
Authors: Kokaua Jesse , Kolose-Pulefolau Betty , Ruhe Troy , Aldridge Faith , Foliaki Siale , Kokaua Liam , Mapusua Talai , Dacombe Joanne , Richards Rosalina , Blakelock Russell , Bowden Nicholas 
Published: December 2023

Studies have found early detection of autism is protective for an individual and their family. Fewer Pacific children are diagnosed with autism compared with non-Pacific children, and those who have significantly higher needs, suggesting an undercount of those diagnosed. The purpose of this study was to explore any association between parental education and autism in Pacific children living in Aotearoa, New Zealand. This was a national cross-sectional study using data from New Zealand’s Integrated Data Infrastructure, including Pacific and non-Māori non-Pacific children in the 2013 Census. A novel method was employed to capture autism, while years of parents’ education was estimated from their highest attained qualification level. Apposite regression models were used to analyse the relationship between parental education and autism. We found that autism was identified in 1.1% of Pacific children compared with 1.6% of non-Māori, non-Pacific children. A year of education among parents of Pacific children was associated with increased identification of autism (odds ratio = 1.10; 95% confidence interval = 1.06–1.15). The findings show education plays a positive role in receiving a diagnosis for Pacific autistic children but suggest a systemic failure to support Pacific parents to navigate existing health systems for themselves or their children. Lay abstract Previous studies of autism in Aotearoa, New Zealand, suggest that fewer Pacific children receive an autism diagnosis compared to European children. This study aimed to explore if formal education qualification of parents is related to receiving an autism diagnosis for their Pacific child. Our findings show that autism was identified in 1.1% of Pacific children compared with 1.6% among non-Māori, non-Pacific children. Parents with higher levels of education were more likely to receive an autism diagnosis for their Pacific child. While the study findings indicate education plays a positive role in receiving a diagnosis for autistic children, they suggest a systemic failure of supporting Pacific parents and communities to navigate the health and education systems that exist in Aotearoa, New Zealand.
Crystal structure of dihydroxy(2,4,6-triisopro-pylphenyl)telluronium trifluoromethanesulfonate, C16H25F3O5STe
Authors: Shibuya Yuga , Mihoya Aya , Koguchi Shinichi , Oba Makoto 
Published: December 2023

Abstract
C16H25F3O5STe, monoclinic, P21/c (no. 14), a = 5.8214(2) Å, b = 16.0059(5) Å, c = 21.9311(7) Å, β = 94.760(3)°, V = 2036.42(12) Å3, Z = 4, R
gt(F) = 0.0282, wR
ref(F
2) = 0.0598, T = 293 K.
Sonderforschungsbereich 1574: Kreislauffabrik für das ewige innovative Produkt
Authors: Lanza Gisela , Klenk Felix , Martin Michael , Brützel Oliver , Hörsting Rick 
Published: December 2023

Abstract
Um Ressourcenverbrauch und Wohlstand zu entkoppeln, sind zirkuläre Muster notwendig. Der Artikel stellt die Vision einer Kreislauffabrik für das ewige innovative Produkt vor, die die lineare und zirkuläre Produktion integriert und mittels Produkt-Produktions-CoDesign Gebrauchtprodukte in aktuelle Produktgenerationen überführt. Hierzu ist die Erforschung von Fragestellungen aus den Bereichen Produktionstechnik, Produktentwicklung und Werkstofftechnik, Arbeitswissenschaft, Robotik, Informatik und Wissensmodellierung notwendig.
ІННОВАЦІЇ КОМБІКОРМОВИХ ТЕХНОЛОГІЙ ХХІ СТОЛІТТЯ
Authors: Єгоров Богдан Вікторович , Макаринська Алла Василівна , Турпурова Тетяна Михайлівна 
Published: December 2023

Тваринництво є ключовою галуззю у забезпеченні населення якісними харчовими продуктами тваринного походження, тим самим забезпечує національну продовольчу безпеку країни, та стратегічно важливою галуззю у загальній структурі сільськогосподарського виробництва, на яке припадає близько 20% загального виробництва. Згідно зі статистичними даними, щорічне споживання м’яса та м’ясопродуктів на одну людину за останні 15 років становило близько 55 кг, що на 25 кг менше від прийнятної норми (80 кг).
Україна має сприятливі умови для вирощування сільськогосподарських тварин та птиці. При організації виробничо-технологічного ланцюга виробництва продукції тваринництва, особливу увагу слід приділяти етапу виробництва комбікормів – максимально ефективно використовувати сировину, ретельно її переробляти, розширювати асортимент і покращувати якість продукції тваринництва для забезпечення продовольчої безпеки країни.
Наведено структуру формування ефективності виробництва продукції тваринництва та показано, що на ефективність виробництва тваринницької продукції понад 60 % усіх витрат впливає якість годівлі сільськогосподарських тварин: рівень організації технології, повноцінна годівля тварин, якість та безпечність сировини. Проблема виробництва якісної та безпечної тваринницької продукції вирішується шляхом впровадження інноваційних технологій, серед яких, насамперед, технології виробництва високоякісної комбікормової продукції. В основу цих технологій покладено досвід та знання багатьох вчених, фундаторів комбікормової галузі. В представленій роботі наведені матеріали щодо фундаторів комбікормової галузі, які внесли значний вклад в становлення та розвиток комбікормової промисловості.
Проведено скринінг розроблених та впроваджених інноваційних технологій виробництва комбікормів, які відіграють значну роль у підвищенні ефективності виробництва та якості продукції. Наукова школа «Наукові основи та енергозберігаючі технології виробництва комбікормової продукції» під керівництвом професора Єгорова Б.В. створює можливості поєднання теорії та практики, новітніх наукових розробок, які мають вагомий внесок у підвищення конкурентоспроможності комбікормової галузі. Проаналізовано тенденції багатосторонньої діяльності наукової школи – видавництво підручників, навчальних посібників, науково-практичного журналу «Зернові продукти і комбікорми», проведення Міжнародної школи кормів, виїзних семінарів на підприємства галузі дозволяє здійснювати підготовку та підвищення кваліфікації професорсько-викладацького складу та інженерних кадрів.
Conjugates of 8-[2,2’-bipyridinyl]coumarins as potential chemosensors for Al3+, Cu2+, Cd2+, Zn2+ ions: synthesis and photophysical properties
Authors: Sharapov Ainur D. , Fatykhov Ramil F. , Khalymbadzha Igor A. , Kopchuk Dmitry S. , Nikonov Igor L. , Potapova Anastasiya P. , Shtaitz Yaroslav K. , Slepukhin Pavel A. 
Published: December 2023

In this work, we report the synthesis of novel coumarin-bipyridine conjugates using a sequence of C–C coupling reaction between 5,7-dimethoxycoumarins and 3-pyridyl-6-aryl-1,2,4-triazines followed by the Boger reaction with norbornandiene to obtain 8-[2,2'-bipyridyl]-5,7-dimethoxycoumarins. Photophysical properties were investigated for the obtained series of 8-[2,2'-bipyridyl]-5,7-dimethoxycoumarins: absorption and emission wavelength maxima are in the region of 212–296 and 401–410 nm, respectively; Stokes shifts are up to 116 nm, and fluorescence quantum yields are up to 15.0%. It was found that titrating the conjugates with Al3+, Zn2+, and Cd2+ ions results in an increase in the intensity of the emission maxima of the complexes, while the opposite effect was observed in the case of titration with Cu2+ ions. These findings suggest that the studied compounds may be considered as promising chemosensing materials. Finally, a positive solvatochromism of 8-[2,2'-bipyridyl]coumarins and their metal complexes was established. The experimental data are supported by mathematical calculations according to the Lippert-Mataga equation and Kosower diagram.
Application of Propofol Target-Controlled Infusion Combined with Etomidate in Painless Gastrointestinal Endoscopy: A Prospective, Randomized Controlled Study
Authors: Luo Huirong , Zheng Ting , Chen Andi , Lin Jingfang , Ye Peng , Chen Yingjie , Lin Mingxue , Chen Lifei , Chen Pinzhong , Chen Xiaohui , Zheng Xiaochun 
Published: December 2023

Abstract
Background
Propofol has been widely used in painless gastrointestinal endoscopy; however, it frequently leads to cardiovascular adverse events and respiratory depression. Propofol target-controlled infusion (TCI) can provide safe sedation but may require higher dosages of propofol. On the contrary, etomidate offers hemodynamic stability. This study aimed to investigate the efficacy and safety of propofol TCI combined with etomidate in painless gastrointestinal endoscopy.
Methods
A total of 330 patients from Fujian Provincial Hospital were randomly divided into three groups: P, 0.1EP, and 0.15EP. Patients in the P group received propofol TCI only, with an initial effect-site concentration of the propofol TCI system of 3.0 µg/mL. Patients in the 0.1EP and 0.15EP groups received 0.1 and 0.15 mg/kg etomidate intravenous injection, respectively, followed by propofol TCI.
Results
Patients in the 0.15EP group had higher mean blood pressure (MBP) after induction than the other groups (P < 0.05). Propofol consumption significantly decreased in the 0.15EP group compared with that in the other groups (P < 0.05). The induction time was longer in the P group than in the other groups (P < 0.01). The recovery time was shorter in the 0.15EP group than in the other groups (P < 0.01). The incidence of hypotension and injection pain was lower in the 0.15EP group than in the other groups (P < 0.05). Furthermore, the incidence of respiratory depression was lower in the 0.15EP group than in the P group (P < 0.05). Additionally, the satisfaction of the patient, endoscopist, and anesthesiologist was higher in the 0.15EP group than in the other groups (P < 0.05).
Conclusions
Our findings suggest that 0.15 mg/kg etomidate plus propofol TCI can significantly reduce propofol consumption, which is followed by fewer cardiovascular adverse events and respiratory depression, along with higher patient, endoscopist, and anesthesiologist satisfaction. Thus, this anesthesia strategy is suitable for painless gastrointestinal endoscopy.
Segmentation of Liver CT Images Based on Weighted Medical Transformer Model
Authors: Gu Qun , Zhang Hai , Cai Rui , Sui Si Yi , Wang Rui 
Published: December 2023

Abstract

Deep Convolutional Neural Networks have been developed in the field of medical image segmentation, although the existing convolutional structure in which the local information of the image is utilized improves the performance, but the dependency information between the contexts is lost. Therefore highly expresses the relationship between contexts using the multi-attention mechanism in the Transformer structureand applies the Transformer network architecture to medical CT liver image segmentation. Most of the models based on this Transformer structure require a large number of datasets for training, but for the medical field, the sample size of the dataset is so small that it is difficult to train the model of the Transformer structure, for this reason, a Weighted Medical Transformer (WMT) model is proposed. This weighting mechanism can improve the problem of inaccurate relative position encoding when the amount of data is insufficient. At the same time, the feature fusion of coarse-grained segmentation and fine-grained segmentation has the advantage of focusing on the inter-block dependency information in coarse-grained segmentation and the intra-block detail information in fine-grained segmentation. The experimental results of this model on the CT dataset show that the F1 score and Iou score are as high as 88.48% and 79.41%, and the accuracy is higher than that of uet++ and Axial Attention U-Net and so on. The method does not require a large dataset and has high execution efficiency compared to other methods.
Exploration of key genes and pathways in response to submergence stress in red clover (Trifolium pratense L.) by WGCNA
Authors: Shang Panpan , Bi Lei , Li Wenwen , Zhou Xiaoli , Feng Yanlong , Wu Jiahai , Zeng Bing 
Published: December 2023

Abstract

Background
Submergence stress is a prevalent abiotic stress affecting plant growth and development and can restrict plant cultivation in areas prone to flooding. Research on plant submergence stress tolerance has been essential in managing plant production under excessive rainfall. Red clover (Trifolium pratense L.), a high-quality legume forage, exhibits low tolerance to submergence, and long-term submergence can lead to root rot and death.
Results
This study assessed the microstructure, physiological indicators, and the key genes and metabolic pathways under submergence stress in the root system of red clover HL(Hong Long) and ZY(Zi You) varieties under submergence stress at 0 h, 8 h, 24 h, 3 d, and 5 d. Based on 7740 transcripts identified in the leaves at 0 h, 8 h, and 24 h submergence stress, Weighted Gene Co-expression Network Analysis (WGCNA) was performed on the differentially expressed genes (DEGs) at 8 h and 24 h. Functional annotation of the DEGs in the four key modules was obtained. Based on the results, the red clover root system exhibited epidermal cell rupture, enlargement and rupture of cortical thin-walled cells, thickening of the mid-column, and a significant increase in the number of air cavities and air cavity area of aeration tissue with the prolongation of submergence stress. The malondialdehyde content, relative conductivity, peroxidase, and superoxide dismutase initially increased and decreased as submergence stress duration increased. Four specific modules (cyan, purple, light cyan, and ivory) closely correlated with each stress were identified by WGCNA. The 14 obtained Hub genes were functionally annotated, among which six genes, including gene51878, gene11315, and gene11848, were involved in glyoxylate and dicarboxylic acid metabolism, carbon fixation in photosynthetic organisms, carbon metabolism, biosynthesis of pantothenic acid and CoA, flavonoid biosynthesis.
Conclusion
In this study, the molecular response mechanisms of red clover to submergence stress were elucidated, and the core genes and metabolic pathways in response to submergence stress were obtained, providing a valuable data resource at the physiological and molecular levels for subsequent studies of submergence stress tolerance in plants.
Variations of streamflow and sediment yield in the Mosul-Makhool Basin, North Iraq under climate change: a pre-dam construction study
Authors: Rasheed Nisreen Jawad , Al-Khafaji Mahmoud S. , Alwan Imzahim A. 
Published: December 2023

Abstract

The Makhool Dam has brought much attention to the Mosul-Makhool Basin (MMB) in Iraq. Dam construction needs comprehensive studies on the impact of climate change on streamflow and sediment yield in watersheds that supply dams; however, there have been no such investigations conducted on the MMB. An ensemble of three General Circulation Models from Coupled Model Intercomparison Project Phase 6 (CMIP6) with two Shared Socioeconomic Pathways scenarios (SSP2–4.5 and SSP5–8.5) was used to predict the impact of climate change. A distribution mapping downscaling method was utilized to improve the biased climate data. The results indicate that precipitation decreased by 9.5 and 18.7% under SSP2–4.5 and SSP5–8.5 scenarios at the end of the 21st century. The average maximum and minimum temperatures are projected to rise by 2.4 and 1.8 °C in SSP2–4.5 and rise by 3.5 and 2.8 °C in SSP5–8.5 during the study period. The streamflow is expected to decrease by 36.6 and 45.9%, and sediment yield will reduce by 46 and 55% within the same scenarios. Understanding the consequences of climate change helps to face abrupt climate changes to manage dam construction and treat water resources successfully. The results of this research are expected to contribute to improving water management strategies in the study region.
Temporal variation in glacier surface area and glacial lakes in glaciated river basins of Arunachal Pradesh
Authors: Murtem Rimum , Mandal Sameer , Nunchhani V. , Megozeno  , Bandyopadhyay Arnab , Bhadra Aditi 
Published: December 2023

Abstract

Climate change-induced glacier recession has sparked a dynamic transformation of glaciers in high-mountain areas worldwide, resulting in genesis, expansion, and dissipation of glacial lakes that pose a potential threat to downstream communities, underscoring the need for regular monitoring. This study incorporates the automated glacier extraction index to improve debris-free glacier mapping accuracy by reducing water and shadow area categorization errors using multi-temporal Landsat-5 Thermal Mapper, Landsat-8 Operational Land Imager, and digital elevation model (Shuttle Radar Topography Mission) to obtain precise glacier extent. Waterbodies were delineated using thresholding techniques applied to water indices: normalized difference water index, modified normalized difference water index, normalized difference turbidity index, and slope information. The study attempted to map and analyze the temporal variations of glaciers and glacier lakes in the glaciated sub-basins of Arunachal Pradesh: Dibang Basin, Mago Basin, and Subansiri Basin. Glaciers receded at a shrinkage rate of 1.08% per year (1988–2017) in Mago Basin, 1.01% per year (2013–2022) in Subansiri Basin, and 1.42% per year (1995–2021) in Dibang Basin. Glacier lakes showed an increasing trend in number and area due to glacier melt, expanding at rates of 3.31% in the Mago Basin, 0.48% in the Subansiri Basin, and 0.68% in the Dibang Basin per year. Findings suggest that global climate change is likely the primary factor driving glacier changes in these basins.
Comparisons between endoscopic and histologic evaluation of the gastrointestinal tract in dogs and cats: 75 cases (1984–1987)
Authors: Roth Lois , Leib Michael S. , Davenport Deborah J. , Monroe William E. 
Published: December 2023

Summary
Observations made during endoscopic evaluation of the stomach, duodenum, and colon of 58 dogs and 17 cats with a history of regurgitation, vomiting, and/or diarrhea were compared with results of histologic examination of tissues obtained during the procedures. Endoscopic observations included normal mucosa, alternations in mucosal color and texture, and luminal masses. Although endoscopy alone is a useful technique for detecting alterations of the gastrointestinal mucosa, histologic assessment of tissues obtained is necessary to confirm either an inflammatory or a neoplastic process.
Decreased colostral immunoglobulin absorption in calves with postnatal respiratory acidosis
Authors: Besser Thomas E. , Szenci Otto , Gay Clive C. 
Published: December 2023

Summary
The effect of postnatal acid-base status on the absorption of colostral immunoglobulins by calves was examined in 2 field studies. In study 1, blood pH at 2 and 4 hours after birth was related to serum IgG1 concentration 12 hours after colostrum feeding (P < 0.05). Decreased IgG1 absorption from colostrum was associated with respiratory, rather than metabolic, acidosis, because blood PCO2 at 2 and 4 hours after birth was negatively related to IgG1 absorption (P < 0.05), whereas serum bicarbonate concentration was not significantly related to IgG1 absorption.
Acidosis was frequently observed in the 30 calves of study 1. At birth, all calves had venous PCO2 value ≥ 60 mm of Hg, 20 of the calves had blood pH < 7.20, and 8 of the calves had blood bicarbonate concentration < 24 mEq/L. Blood pH values were considerably improved by 4 hours after birth; only 7 calves had blood pH values < 7.20.
Calves lacking risk factors for acidosis were examined in study 2, and blood pH values at 4 hours after birth ranged from 7.25 to 7.39. Blood pH was unrelated to IgG1 absorption in the calves of study 2. However, blood PCO2 was again found to be negatively related to colostral IgG1 absorption (P < 0.005).
Results indicate that postnatal respiratory acidosis in calves can adversely affect colostral immunoglobulin absorption, despite adequate colostrum intake early in the absorptive period.