bluuebunny/crossref_metadata_2025_split huggingface dataset:
Language is a critical mediator of autistic experiences within the criminal justice system
Authors: Larson Caroline , Eigsti Inge‐Marie , Spaulding Tammie , Parish‐Morris Julia 
Published: October 2023

AbstractAutism spectrum disorder is characterized by social communication challenges and restricted and repetitive behaviors and interests, but also by highly heterogeneous language skills. The recent International Society of Autism Research (INSAR) policy statement, Autism and the Criminal Justice System: Policy opportunities and challenges (INSAR, 2022), aims to prevent, reduce, and improve interactions between autistic individuals and the criminal justice system. This policy statement provides a foundation for considering how to include language in these important aims. In this commentary, we outline the centrality of language skills to these interactions and provide specific recommendations that can inform future research and provide guidance for autistic individuals, community partners, and individuals working within the criminal justice system. Considering language as a part of justice system policy for autistic individuals will result in greater equity and inclusion, particularly for autistic individuals with co‐occurring language deficits and those who are linguistically diverse. Moreover, it will allow autistic individuals to combat other barriers to effectively navigating interactions with the criminal justice system, such as those related to the core features of autism. We advocate for a greater role for service providers who can assess challenges in language skills, and identify the specific accommodations each autistic individual will need to prevent, reduce, and improve interactions with the criminal justice system.
Spray‐coated Hard Carbon Composite Anodes for Sodium‐Ion Insertion
Authors: Palanisamy Krishnaveni , Daboss Sven , Schäfer David , Rohnke Marcus , Derr Laurin , Lang Marcel , Schuster Rolf , Kranz Christine 
Published: October 2023

AbstractSodium‐ion batteries are among the most promising alternatives to lithium‐ion batteries. Hard carbon (HC) electrodes have been recognized as suitable active anode material for mono‐valent ion batteries. Here, we present a simple and cost‐effective spray‐coating process to prepare HC composite electrodes on copper current collectors with different binder (sodium carboxymethyl cellulose, CMC) content and different HC particle sizes. The spray‐coated electrodes were evaluated and tested in 1 M sodium perchlorate (NaClO4) in propylene carbonate (PC) in dependence of the CMC content with and without fluoroethylene carbonate (FEC) as additive, and the performance was also compared to doctor bladed HC electrodes. Spray‐coated anodes in Na half‐cells revealed improved capacity during the first cycles compared with doctor bladed anodes with similar thicknesses. Time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) studies were performed, which revealed a significant increase of inorganic fluoro‐compounds in the formed solid electrolyte interphase (SEI) when FEC was present as additive. In addition, first single electrode microcalorimetry studies on spray‐coated thin HC composite electrodes yielded an entropy of the sodiation process of 80 J mol−1 K−1 at high state of charge (SoC), comparable to that of bulk Na deposition.
Lifetime and past‐month alcohol use and related factors among female sex workers in Iran
Authors: Rasouli Mohammad Aziz , Zareie Bushra , Gouya Mohammad Mehdi , Hadavandsiri Fatemeh , Mahboobi Marzieh , Moradi Yousef , Moradi Rozhin , Moradi Ghobad 
Published: October 2023

AbstractObjectiveAlcohol use is more common among female sex workers (FSWs). This study assessed the prevalence of lifetime and past‐month alcohol use and related factors among FSWs in Iran.MethodsWe conducted a cross‐sectional survey among 1464 women from 8 major cities in Iran. Behavioral data were collected by trained interviewers and conducted face‐to‐face in a private room. Weighted analysis was used to determine the lifetime and past‐month alcohol use prevalence. Univariate and multivariate logistic regression was used to investigate the association between alcohol use and independent variables.ResultsThe most alcohol used in lifetime and past‐month (weekly, less than once a week, and daily) in FSWs was 52.7% (12.25%, 12.94%, and 1.83%), respectively. In the final model, factors that were independently associated with alcohol use included the 31–40 years (AOR = 2.41, 95% CI: 1.13–5.15), education level of diploma (AOR = 2.43, 95% CI: 1.31–4.51), history of lifetime drug use (AOR = 2.79, 95% CI: 2.01–3.89), history of lifetime group sex (AOR = 2.07, 95% CI: 1.41–3.03), history of intentional abortion (AOR = 1.42, 95% CI: 1.06–1.92), six or more sexual clients in the last month (AOR = 3.25, 95% CI: 1.80–5.87), history of lifetime anal sex (AOR = 2.47, 95% CI: 1.82‐3.35), and FSWs the married, temporarily married, and living with partner were positively associated with lifetime alcohol use.ConclusionAlcohol use is prevalent among FSWs in Iran. Further prevention programs are needed to address and reduce harms associated with alcohol use among this vulnerable population in Iran. Designing intervention programs, it is suggested to consider other variables affecting alcohol use in FSWs.
Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies
Authors: Barnard Gavin C. , Zhou Michelle , Shen Amy , Yuk Inn H. , Laird Michael W. 
Published: October 2023

AbstractMonoclonal antibodies (mAbs) are effective therapeutic agents against many acute infectious diseases including COVID‐19, Ebola, RSV, Clostridium difficile, and Anthrax. mAbs can therefore help combat a future pandemic. Unfortunately, mAb development typically takes years, limiting its potential to save lives during a pandemic. Therefore “pandemic mAb” timelines need to be shortened. One acceleration tool is “deferred cloning” and leverages new Chinese hamster ovary (CHO) technology based on targeted gene integration (TI). CHO pools, instead of CHO clones, can be used for Phase I/II clinical material production. A final CHO clone (producing the mAb with a similar product quality profile and preferably with a higher titer) can then be used for Phase III trials and commercial manufacturing. This substitution reduces timelines by ~3 months. We evaluated our novel CHO TI platform to enable deferred cloning. We created four unique CHO pools expressing three unique mAbs (mAb1, mAb2, and mAb3), and a bispecific mAb (BsAb1). We then performed single‐cell cloning for mAb1 and mAb2, identifying three high‐expressing clones from each pool. CHO pools and clones were inoculated side‐by‐side in ambr15 bioreactors. CHO pools yielded mAb titers as high as 10.4 g/L (mAb3) and 7.1 g/L (BsAb1). Subcloning yielded CHO clones expressing higher titers relative to the CHO pools while yielding similar product quality profiles. Finally, we showed that CHO TI pools were stable by performing a 3‐month cell aging study. In summary, our CHO TI platform can increase the speed to clinic for a future “pandemic mAb.”
Immunological Quantitation of the Glycation Site Lysine‐414 in Serum Albumin in Human Plasma Samples by Indirect ELISA Using Highly Specific Monoclonal Antibodies
Authors: Mötzing Marina , Blüher Matthias , Grunwald Thomas , Hoffmann Ralf 
Published: October 2023

AbstractDiabetes mellitus, a metabolic disorder that is characterized by elevated blood glucose levels, is common throughout the world and its prevalence is steadily increasing. Early diagnosis and treatment are important to prevent acute complications and life‐threatening long‐term organ damage. Glycation sites in human serum albumin (HSA) are considered to be promising biomarkers of systemic glycemic status. This work aimed to develop a sensitive and clinically applicable ELISA for the quantification of glycation site Lys414 in HSA (HSAK414). The monoclonal antibodies (mAbs) were generated by immunizing mice with a glycated peptide. The established indirect ELISA based on mAb 50D8 (IgG1 isotype) yielded a limit of detection of 0.39 nmol/g HSA for HSAK414 with a linear dynamic range from 0.50 to 6.25 nmol/g glycated HSA. The inter‐ and intra‐day assays with coefficients of variation less than 20 % indicated good assay performance and precision. Assay evaluation was based on plasma samples from diabetic and non‐diabetic subjects with known HSAK414 glycation levels previously determined by LC–MS. Both data sets correlated very well. In conclusion, the generated mAb 50D8 and the established ELISA could be a valuable tool for the rapid quantitation of glycation site HSAK414 in plasma samples to evaluate its clinical relevance.
Monitoring of Sweat pH and Dual‐Mode Anti‐Counterfeiting from Metal‐Organic Framework‐Based Multifunctional Gel
Authors: Wang Xiangnan , Zhang Hongli , Li Jiahe , Zou Gang 
Published: October 2023

Comprehensive SummaryMonitoring of sweat pH plays important roles in physiological health, nutritional balance, psychological stress, and sports performance. However, the combination of functional MOFs with phosphorescent material to acquire the real‐time physiological information, as well as the application of dual mode anti‐counterfeiting, has seldom been reported. Herein, we developed multifunctional gel films based on MOFs and phosphorescent dyes which responded to H+ ions and the related mechanism was studied in detail. Upon exposure to H+, the composite gel film exhibited decreased fluorescent signal but enhanced room temperature phosphorescence (RTP), which could be utilized for sweat pH sensing through a dual‐mode. Moreover, multifunctional gel films exhibited a potential application in information encryption and anti‐counterfeiting by designing of stimulus responsive multiple patterns. This research provided a new avenue for portable and non‐invasive sweat pH monitoring methods while also offering insights into stimulus‐responsive multifunctional materials.
Cardioversion strategy impacts rate control during recurrences in patients with paroxysmal atrial fibrillation: A subanalysis of the RACE 7 ACWAS trial
Authors: van der Velden Rachel M. J. , Pluymaekers Nikki A. H. A. , Dudink Elton A. M. P. , Luermans Justin G. L. M. , Meeder Joan G. , Heesen Wilfred F. , Lenderink Timo , Widdershoven Jos W. M. G. , Bucx Jeroen J. J. , Rienstra Michiel , Kamp Otto , van Opstal Jurren M. , Kirchhof Charles J. H. J. , van Dijk Vincent F. , Swart Henk P. , Alings Marco , Van Gelder Isabelle C. , Crijns Harry J. G. M. , Linz Dominik 
Published: October 2023

AbstractBackgroundIn the Rate Control versus Electrical Cardioversion Trial 7–Acute Cardioversion versus Wait and See, patients with recent‐onset atrial fibrillation (AF) were randomized to either early or delayed cardioversion.AimThis prespecified sub‐analysis aimed to evaluate heart rate during AF recurrences after an emergency department (ED) visit identified by an electrocardiogram (ECG)‐based handheld device.MethodsAfter the ED visit, included patients (n = 437) were asked to use an ECG‐based handheld device to monitor for recurrences during the 4‐week follow‐up period. 335 patients used the handheld device and were included in this analysis. Recordings from the device were collected and assessed for heart rhythm and rate. Optimal rate control was defined as a target resting heart rate of <110 beats per minute (bpm).ResultsIn 99 patients (29.6%, mean age 67 ± 10 years, 39.4% female, median 6 [3–12] AF recordings) a total of 314 AF recurrences (median 2 [1–3] per patient) were identified during follow‐up. The average median resting heart rate at recurrence was 100 ± 21 bpm in the delayed vs 112 ± 25 bpm in the early cardioversion group (p = .011). Optimal rate control was seen in 68.4% [21.3%–100%] and 33.3% [0%–77.5%] of recordings (p = .01), respectively. Randomization group [coefficient −12.09 (−20.55 to −3.63, p = .006) for delayed vs. early cardioversion] and heart rate on index ECG [coefficient 0.46 (0.29–0.63, p < .001) per bpm increase] were identified on multivariable analysis as factors associated with lower median heart rate during AF recurrences.ConclusionA delayed cardioversion strategy translated into a favorable heart rate profile during AF recurrences.
Psychometric evaluation of the Swedish Traumatic Grief Inventory Self‐Report Plus (TGI‐SR+) in bereaved parents
Authors: Lenferink Lonneke I. M. , van Dijk Iris , Eisma Maarten C. , Eklund Rakel , Boelen Paul A. , Sveen Josefin 
Published: October 2023

AbstractThe International Classification of Diseases Eleventh Edition (ICD‐11), and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM‐5‐TR), now include prolonged grief disorder (PGD). Since criteria for PGD in both classification systems differ from prior proposed grief disorders and each other, the validation of a single instrument to screen for prolonged grief (PG) symptoms of both new diagnoses is critical for bereavement research and care. Therefore, we evaluated the psychometric properties of the Swedish version of the Traumatic Grief Inventory Self‐Report Plus (TGI‐SR+). Two‐hundred and forty‐eight bereaved parents completed questions about sociodemographic and loss‐related variables, the TGI‐SR+, and symptom measures of post‐traumatic stress (PTS), depression and an older measure of PG symptoms, the Prolonged Grief Disorder‐13 (PG‐13). Confirmatory factor analyses showed that a one‐factor model best fit DSM‐5‐TR and ICD‐11 PG symptoms and the analyses of the internal consistency and inter‐item correlations showed that these symptoms could be reliably assessed. In support of convergent validity, DSM‐5‐TR and ICD‐11 PG symptoms correlated with symptoms of PTS, depression and PG assessed with the PG‐13. In support of known‐groups validity, DSM‐5‐TR and ICD‐11 PG symptoms were higher among lower educated (vs. higher educated) participants and related negatively to time since loss. ROC analyses showed optimal cut‐off score of ≥71 and ≥72 to determine probable caseness for DSM‐5‐TR and ICD‐11 PGD, respectively. Results support the reliability and validity of the Swedish TGI‐SR+ as a screening instrument for PG in research and bereavement care.
spatialMaxent: Adapting species distribution modeling to spatial data
Authors: Bald Lisa , Gottwald Jannis , Zeuss Dirk 
Published: October 2023

AbstractConventional practices in species distribution modeling lack predictive power when the spatial structure of data is not taken into account. However, choosing a modeling approach that accounts for overfitting during model training can improve predictive performance on spatially separated test data, leading to more reliable models. This study introduces spatialMaxent (https://github.com/envima/spatialMaxent), a software that combines state‐of‐the‐art spatial modeling techniques with the popular species distribution modeling software Maxent. It includes forward‐variable‐selection, forward‐feature‐selection, and regularization‐multiplier tuning based on spatial cross‐validation, which enables addressing overfitting during model training by considering the impact of spatial dependency in the training data. We assessed the performance of spatialMaxent using the National Center for Ecological Analysis and Synthesis dataset, which contains over 200 anonymized species across six regions worldwide. Our results show that spatialMaxent outperforms both conventional Maxent and models optimized according to literature recommendations without using a spatial tuning strategy in 80 percent of the cases. spatialMaxent is user‐friendly and easily accessible to researchers, government authorities, and conservation practitioners. Therefore, it has the potential to play an important role in addressing pressing challenges of biodiversity conservation.
Cardiac reverse remodelling by imaging parameters with recent changes to guideline medical therapy in heart failure
Authors: Kodsi Matthew , Makarious David , Gan Gary C.H. , Choudhary Preeti , Thomas Liza 
Published: October 2023

AbstractRecently established heart failure therapies, including sodium glucose co‐transporter 2 inhibitors, angiotensin‐neprilysin inhibitors, and cardiac resynchronization therapy, have led to both clinical and structural improvements. Reverse remodelling describes the structural and functional responses to therapy and has been shown to correlate with patients' clinical response, acting as a biomarker for treatment success. The introduction of these new therapeutic agents in addition to advances in non‐invasive cardiac imaging has led to an expansion in the evaluation and the validation of cardiac reverse remodelling. Methods including volumetric changes as well as strain and myocardial work have all been shown to be non‐invasive end‐points of reverse remodelling, correlating with clinical outcomes. Our review summarizes the current available evidence on reverse remodelling in heart failure by the non‐invasive cardiac imaging techniques, in particular transthoracic echocardiography.
Covalent Association of a Ruthenium‐Based Chromophore and a Copper Catalyst: A Synergy for Sulfides Photo‐oxidation
Authors: Klein Johannes , Girardon Anna , Moreno‐Betancourt Angelica , Loiseau Frédérique , Jouvenot Damien , Pécaut Jacques , Hamelin Olivier , Torelli Stéphane 
Published: October 2023

AbstractThe development of catalytic systems for the oxidation of organic substrates using renewable sources such as water and dioxygen remains challenging. In this paper we report the synthesis and full characterization of a new dyad combining a ruthenium(II)‐based chromophore and a bio‐inspired copper(II) pre‐catalyst. In particular, photo‐induced electron transfer from the photosensitized RuII subunit toward the CuII center is highlighted. The photogenerated CuI moiety proves to be catalytically efficient for sulfides oxidation by 3O2 in the presence of a sacrificial electron source. Finally, the covalent association of the two partners favors Cu/O2‐based catalysis at the expense of a 1O2‐centered reactivity for a bimolecular mixture.
Numerical simulation study of wave dissipation performance of step‐type breakwaters
Authors: Jin Feng , Huang Zhouyi , Deng Wenhao , Chen Minyi , Ma You , Chai Peng 
Published: October 2023

AbstractTo improve the force endurance capacity of plate breakwaters, a step‐type plate breakwater was proposed. The performance of the step‐type breakwater was investigated by numerical simulation method. First, a two‐dimensional numerical regular wave tank was constructed using FLUENT software, and the effectiveness of the tank application was verified by comparing with theoretical value and test data. Then, the numerical tank was used to simulate various working conditions, and the variation rules of the breakwater transmission coefficient with wave height, period, perforation rate, relative plate width, wave steepness, and number of layers were obtained. Finally, the difference in the wave dissipation mechanism between the step‐type breakwater and the “”‐type breakwater was discussed. The results indicated that the transmission coefficient of the step‐type breakwater was small, which also proved to be good at dissipating long‐period waves. In general, the wave dissipation performance of the step‐type breakwater was better than that of the “”‐type breakwater. The research can provide some clues for the research and design of corresponding breakwaters.
Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study
Authors: Braaß Hanna , Feldheim Jan , Chu Ying , Tinnermann Alexandra , Finsterbusch Jürgen , Büchel Christian , Schulz Robert , Gerloff Christian 
Published: October 2023

AbstractForce generation is a crucial element of dexterity and a highly relevant skill of the human motor system. How cerebral and spinal components interact and how spinal activation is associated with the activity in the cerebral primary motor and premotor areas is poorly understood. Here, we conducted combined cortico‐spinal functional magnetic resonance imaging during a simple visually guided isometric force generation task in 20 healthy young subjects. Activation was localized in the right cervical spinal cord and left primary motor and premotor areas. The main finding is that spinal activation was negatively correlated with ventral premotor cortex activation. Spinal activation was furthermore significantly correlated with primary motor cortex activation, while increasing target forces led to an increase in the amount of activation. These data indicate that human premotor areas such as the ventral premotor cortex might be functionally connected to the lower cervical spinal cord contributing to distal upper limb functions, a finding that extends our understanding of human motor function beyond the animal literature.
Trimethoprim‐Sulfamethoxazole Pharmacokinetics in Trauma Patients
Authors: Hess Mary M. , Boucher Bradley A. , Laizure S. Casey , Stevens Robert C. , Sanders Paula L. , Janning Stephen W. , Croce Martin A. , Fabian Timothy C. 
Published: October 2023

Study Objectives. To characterize the pharmacokinetic profile of trimethoprim‐sulfamethoxazole (TMP‐SMX) in trauma patients and to compare these parameter estimates with those obtained in nontrauma patients.Design. Open‐label, multidose, pharmacokinetic study.Setting. Trauma intensive care unit of a level 1 trauma center located within a regional medical center.Patients. Fifteen adult trauma patients with serious gram‐negative infections. All patients were studied on day 1 of treatment, nine on day 3, three on day 5, and two on day 7. One patient was discontinued from the study because of a possible drug‐induced rash.Interventions. Study patients received TMP 4 mg/kg and SMX 20 mg/kg intravenously every 12 hours. Serial blood sampling was performed up to 4 times per patient between treatment days 1 and 7. Serum was assayed for TMP‐SMX using high‐performance liquid chromatography. A one‐compartment model was fit to the data using maximum likelihood estimation.Measurements and Main Results. Mean (SD) baseline parameter estimates for TMP were volume 2.1 (0.65) L/kg, half‐life 9.7 (3.0) hours, and clearance 2.6 (0.80) ml/min/kg. Estimates for SMX were volume 0.51 (0.10) L/kg, half‐life 7.8 (2.0) hours, and clearance 0.80 (0.29) ml/min/kg. Both volume (p<0.01) and clearance (p<0.001) for SMX were significantly higher and half‐life (p<0.05) significantly shorter than previously reported estimates in nontrauma patients. No significant differences in TMP parameter estimates were found. Neither TMP nor SMX clearance was significantly correlated with estimated creatinine clearance (p>0.05).Conclusion. The results indicate that the pharmacokinetics of SMX in trauma patients differ significantly from nontrauma patients, which may result in lower than expected concentrations using standard dosing guidelines.