bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of risk factors for ewe mortality during the pregnancy and lambing period in extensively managed flocks
Authors: Flay K. J. , Chen A. S. , Yang D. A. , Kenyon P. R. , Ridler A. L. 
Published: December 2023

Abstract
Background
Ewe mortality during pregnancy and lambing is an issue for sheep producers globally, resulting in reduced productivity and profitability, compromised ewe welfare, and poor consumer perception. Despite these negative consequences, there was little investigation into factors associated with ewe death during this time. Therefore, this study aimed to assess associations between ewe body condition score (BCS), weight, reproductive parameters, and risk of mortality during pregnancy and lambing.

Methods
Four cohorts from three commercial New Zealand farms participated, with 13,142 ewe lambs enrolled and followed over time. Data were collected for five consecutive lambings. Visits aligned with key on-farm management times, specifically: prior to breeding, at pregnancy diagnosis (PD), prior to lambing (set-stocking), and, at weaning of their lambs. At each visit, ewes were weighed, BCS assessed and reproductive status was recorded when relevant (litter size at PD and lactation status after lambing). Ewes that died or were culled were recorded, and any ewes that were absent from consecutive visits were presumed dead. Logistic regressions were developed to assess the relationship between weight and BCS at each visit, PD result (single or multiple-bearing) and lactation status (wet or dry) in each year, and, risk of mortality during the pregnancy and lambing period in each year.

Results
In the PD to weaning period, mortality incidence ranged from 6.3 to 6.9% for two-tooth (18-months-old at breeding) to mixed-age (54-months-old at breeding) ewes. For ewe lambs (7 to 8-months-old at breeding), mortality was 7.3% from set-stocking to weaning. Heavier ewe lambs at PD were less likely to die during lambing (OR: 0.978, p = 0.013), as were those with greater set-stocking BCS. In subsequent years, BCS was a predictor of ewe death, with odds of mortality greatest for ewes < BCS 2.5. Additionally, for poorer BCS ewes, increasing weight reduced risk of mortality, but there was no impact of increasing weight in greater BCS ewes.

Conclusions
This study identified risk factors associated with ewe mortality during the pregnancy and lambing period. Flock owners can use these to either cull at-risk ewes or proactively intervene to reduce likelihood of mortality, thereby improving flock productivity, profitability and welfare.
Prognosis prediction based on methionine metabolism genes signature in gliomas
Authors: Zhou Sujin , Zhao Xianan , Zhang Shiwei , Tian Xue , Wang Xuepeng , Mu Yunping , Li Fanghong , Zhao Allan Z. , Zhao Zhenggang 
Published: December 2023

Abstract
Background
Glioma cells have increased intake and metabolism of methionine, which can be monitored with 11 C-L-methionine. However, a short half-life of 11 C (~ 20 min) limits its application in clinical practice. It is necessary to develop a methionine metabolism genes-based prediction model for a more convenient prediction of glioma survival.

Methods
We evaluated the patterns of 29 methionine metabolism genes in glioma from the Cancer Genome Atlas (TCGA). A risk model was established using Lasso regression analysis and Cox regression. The reliability of the prognostic model was validated in derivation and validation cohorts (Chinese Glioma Genome Atlas; CGGA). GO, KEGG, GSEA and ESTIMATE analyses were performed for biological functions and immune characterization.

Results
Our results showed that a majority of the methionine metabolism genes (25 genes) were involved in the overall survival of glioma (logrank p and Cox p < 0.05). A 7-methionine metabolism prognostic signature was significantly related to a poor clinical prognosis and overall survival of glioma patients (C-index = 0.83). Functional analysis revealed that the risk model was correlated with immune responses and with epithelial-mesenchymal transition. Furthermore, the nomogram integrating the signature of methionine metabolism genes manifested a strong prognostic ability in the training and validation groups.

Conclusions
The current model had the potential to improve the understanding of methionine metabolism in gliomas and contributed to the development of precise treatment for glioma patients, showing a promising application in clinical practice.
Impact of stress hyperglycemia ratio, derived from glycated albumin or hemoglobin A1c, on mortality among ST-segment elevation myocardial infarction patients
Authors: Liao Wang , Chen Yuwen , Gao Qiyue , Gan Rongrong , Li Ming , Liu Zhenliang , Liang Jiasheng , Cui Henghua , Ren Kaida , Liu Yabin , Wang Zhengdong , Jiang Jun , Wei Qucheng 
Published: December 2023

Abstract
Background
Stress hyperglycemia ratio (SHR), associated with adverse outcomes in patients with ST-segment elevation myocardial infarction (STEMI), has several definitions. This study aims to assess the prognostic value of SHR, derived from hemoglobin A1c (HbA1c) or glycated albumin (GA), to mortality.

Methods
The study comprised 1,643 STEMI patients who underwent percutaneous coronary intervention (PCI) in two centers. SHR1 was calculated using fasting blood glucose (FBG)/GA, while SHR2 was calculated using the formula FBG/(1.59*HbA1c-2.59). The primary endpoints were in-hospital death and all-cause mortality, with a median follow-up duration of 1.56 years.

Results
Higher SHR1 and SHR2 values are associated with increased risks of in-hospital death and all-cause mortality. Each standard deviation increase in SHR1 corresponded to a 39% and 22% escalation in in-hospital death and all-cause mortality, respectively. The respective increases for SHR2 were 51% and 26%. Further examinations validated these relationships as linear. Additionally, the areas under the curve (AUC) for in-hospital death were not significantly different between SHR1 and SHR2 (p > 0.05). Incorporating SHR1 or SHR2 into the base model significantly improved the discrimination and risk reclassification for in-hospital and all-cause mortality. A subgroup analysis revealed that the effects of SHR1 and SHR2 were more pronounced in patients with hypercholesteremia.

Conclusion
SHR1 and SHR2 have emerged as robust and independent prognostic markers for STEMI patients undergoing PCI. The SHR calculation based on either HbA1c or GA can provide additional predictive value for mortality beyond traditional risk factors, helping to identify high-risk STEMI patients.
People’s political views, perceived social norms, and individualism shape their privacy concerns for and acceptance of pandemic control measures that use individual-level georeferenced data
Authors: Kwan Mei-Po , Huang Jianwei , Kan Zihan 
Published: December 2023

Abstract
Background
As the COVID-19 pandemic became a major global health crisis, many COVID-19 control measures that use individual-level georeferenced data (e.g., the locations of people’s residences and activities) have been used in different countries around the world. Because these measures involve some disclosure risk and have the potential for privacy violations, people’s concerns for geoprivacy (locational privacy) have recently heightened as a result, leading to an urgent need to understand and address the geoprivacy issues associated with COVID-19 control measures that use data on people’s private locations.

Methods
We conducted an international cross-sectional survey in six study areas (n = 4260) to examine how people’s political views, perceived social norms, and individualism shape their privacy concerns, perceived social benefits, and acceptance of ten COVID-19 control measures that use individual-level georeferenced data. Multilevel linear regression models were used to examine these effects. We also applied multilevel structure equation models (SEMs) to explore the direct, indirect, and mediating effects among the variables.

Results
We observed a tradeoff relationship between people’s privacy concerns and the acceptance (and perceived social benefits) of the control measures. People’s perceived social tightness and vertical individualism are positively associated with their acceptance and perceived social benefits of the control measures, while horizontal individualism has a negative association. Further, people with conservative political views and high levels of individualism (both vertical and horizontal) have high levels of privacy concerns.

Conclusions
Our results first suggest that people’s privacy concerns significantly affect their perceived social benefits and acceptance of the COVID-19 control measures. Besides, our results also imply that strengthening social norms may increase people’s acceptance and perceived social benefits of the control measures but may not reduce people’s privacy concerns, which could be an obstacle to the implementation of similar control measures during future pandemics. Lastly, people’s privacy concerns tend to increase with their conservatism and individualism.
Magnitude and factors associated with sexual re-victimization among adolescent girls and young women in Kinshasa, Democratic Republic of the Congo: a retrospective multicenter study
Authors: Biluala Fifiya , Kayembe Harry César , Batumbo Doudou , Kapour Germain , Mumbanza Félicitée , Bokabo Eric , Longo-Mbenza Benjamin , Zinga Berthe 
Published: December 2023

Abstract
Background
Adolescent girls and young women are more exposed to sexual violence. A significant proportion of victims of sexual abuse are victims of sexual re-victimization. However, information on the burden of sexual re-victimization among AGYW in contexts other than conflict-affected areas in the Democratic Republic of the Congo (DRC) is limited. The aim of this study was to assess the magnitude of sexual re-victimization among AGYW and to identify associated risk factors in the capital, Kinshasa.

Methods
We conducted a retrospective multicenter cohort study in which sexual violence records between 2015 and 2020 were used to extract and analyze victims’ sociodemographic and behavioral characteristics and profiles of sexual violence perpetrated. Multivariate logistic regression models were employed to identify factors associated with sexual re-victimization using the adjusted odds ratio (AOR) with its 95% confidence interval (95% CI) and p value < 0.05.

Results
We found that 74 (31%) of the 241 AGYW included in this study had experienced sexual re-victimization. Sexual re-victimization was associated with being older (> 19 years), sexually active, and living in a single-parent family, and with perpetrator types, particularly intimate partners and family members.

Conclusions
Our findings provide tools for developing and implementing targeted prevention and intervention programs to reduce sexual violence in general and sexual re-victimization in particular.
Association of hardware removal with secondary osteonecrosis following femoral neck fractures: a systematic review and meta-analysis
Authors: Jiang Qilong , Deng Yu , Liu Yang , Zhao Zhi , Chen Yu , Bai Xinwen , Hong Hao 
Published: December 2023

Abstract
Background
It has been controversial that whether hardware removal will increase the risk of osteonecrosis of femoral head (ONFH) in fracture-healed patients who underwent internal fixation for femoral neck fractures (FNFs). This meta-analysis aimed to clarify the association of hardware removal with secondary hardware removal-induced ONFH (HR-ONFH).

Methods
Four electronic databases (PubMed, Embase, Web of Science, Cochrane Library) were searched for eligible studies published up to March 10, 2023. Studies reporting the relative risk of hardware status (i.e., risk rate, odds ratio [OR], or hazard ratio [HR]) were included. Newcastle–Ottawa scale (NOS) was used to assess risk of bias of included observational studies. Review Manager software was used to pool ORs and adjusted ORs.

Results
Five studies were included into quantitative synthesis. Hardware removal was associated with a reduced risk of HR-ONFH in the synthesis of crude odds ratios (OR, 0.62, 95% CI 0.39–0.96). In the synthesis of adjusted odds ratios, hardware removal was associated with an increased risk of HR-ONFH (OR, 1.76, 95% CI 1.23–2.51).

Conclusion
This study demonstrates that hardware removal was associated with an increased incidence of HR-ONFH in fracture-healed patients who underwent internal fixation due to FNFs.
Impact of informal caregiving on caregivers’ subjective well-being in China: a longitudinal study
Authors: Cheng Mingmei , Yang Hualei , Yu Qian 
Published: December 2023

Abstract
Background
While informal caregiving is crucial for improving and maintaining health of the elderly, there is limited evidence of its potential effect on caregivers’ wellbeing. Understanding this effect is important for policy makers to design effective long-term care policies. This longitudinal study aims to investigate the impact of informal caregiving on caregivers’ subjective wellbeing in China.

Methods
Three waves (2016, 2018, 2020) of data from the China Family Panel Studies (CFPS) are constructed for empirical analysis. Ordered logit model is first used to estimate the effect. Fixed effects ordered logit model and mixed effects ordered logit model are further employed to control for the possible bias from unobserved individual heterogeneity.

Results
Informal caregiving significantly reduces caregivers’ subjective wellbeing and the negative effect is stronger for high-frequency caregivers. Subgroup analysis reveals that informal caregiving imposed greater negative impacts on women, those living in rural areas, being married, working, and living separately from parents. Further analysis of mechanism indicates that decrease in wage income, leisure and sleep time were channels through which informal caregiving affects caregivers’ well-being.

Conclusion
When policy makers formulate sustainable long-term care policies and home support services, interventions to improve caregivers’ stress-coping skills and ensure their engagement in leisure and social activities could be adopted to mitigate the negative effects on caregivers’ subjective well-being.
Experimental Investigation on the Properties of Sustainable Pervious Concrete with Different Aggregate Gradation
Authors: Zhang Junyu , Sun Haoran , Shui Xiaotian , Chen Wenxuan 
Published: December 2023

AbstractPervious concrete (PC) as a green infrastructure material has been increasingly used due to its positive environmental impacts, such as controlling storm water runoff, removing water pollutants and reducing heat island effect. The aggregate gradation is a critical factor influencing the physical properties of PC. Therefore, this paper represents an attempt to determine the effects of aggregate gradation on the various physical properties of PC, and then to explore relationships between them. To this end, three aggregate gradations 4.75–9.5 mm, 9.5–19 mm and 19–31.5 mm were recombined with various proportions (20–80%) to obtain five different gradations named as A, B, C, D and E. PC mixtures were prepared with these five aggregate gradations. Then, physical and mechanical properties of PC including porosity, permeability, compressive strength and water stability were investigated, according to the available specification. The results suggested that it was feasible to use waste concrete for permeable pavement, because all the specimens provided required specification requirements. Different linear relationships were also found between the maximum aggregate size and porosity, permeability coefficient, compressive strength and its loss rate. That is, porosity and permeability increased with the proportion of larger size aggregate increased, however, compressive strength reduced. Thus the compressive strength had an inverse correlation with the porosity and water permeability. Among five different aggregate gradations, group C (20% of 4.75–9.5 mm aggregate, 50% of 9.5–19 mm aggregate and 30% of 19–31.5 mm aggregate) can be seen as the optimum gradation and is suitable for base layer materials of permeable pavements.
The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin’s lymphoma—an observational study
Authors: Dong Hang , Guo Honglin , Du Jing , Cheng Yiping , Wang Dawei , Han Junming , Yuan Zinuo , Yao Zhenyu , An Ran , Wu Xiaoqin , Poulsen Kyle L. , Wang Zhixiang , Shao Shanshan , Fan Xiude , Wang Zhen , Zhao Jiajun 
Published: December 2023

Abstract
Background
The relationship between obesity and non-Hodgkin’s lymphoma (NHL) was controversial, which may be due to the crudeness definition of obesity based on body mass index (BMI). As obesity and metabolic abnormalities often coexist, we aimed to explore whether the classification of obesity based on metabolic status can help to evaluate the real impact of obesity on the readmission of NHL.

Methods
In this retrospective cohort study, utilizing the 2018 Nationwide Readmissions Database, we identified NHL-related index hospitalizations and followed them for non-elective readmission. The patients with NHL were classified as metabolically healthy non-obese (MHNO) and obese (MHO) and metabolically unhealthy non-obese (MUNO) and obese (MUO). Readmission rates for each phenotype were calculated at 30-day intervals. Multiple COX regression was used to analyze the association of metabolic-defined obesity with 30-day, 90-day, and 180-day readmission rates in patients with NHL.

Results
There were 22,086 index hospitalizations with NHL included. In the multivariate COX regression, MUNO was associated with increased 30-day (HR = 1.113, 95% CI 1.036–1.195), 90-day (HR = 1.148, 95% CI 1.087–1.213), and 180-day readmission rates (HR = 1.132, 95% CI 1.077–1.189), and MUO was associated with increased 30-day (HR=1.219, 95% CI: 1.081-1.374), 90-day (HR = 1.228, 95% CI 1.118–1.348), and 180-day readmission rates (HR = 1.223, 95% CI 1.124–1.33), while MHO had no associations with readmission rates.

Conclusions
The presence of metabolic abnormalities with or without obesity increased the risk of non-selective readmission in patients with NHL. However, obesity alone had no associations with the risk of non-selective readmission, suggesting that interventions for metabolic abnormalities may be more important in reducing readmissions of NHL patients.
A mobile phone intervention to reduce heavy drinking: a preliminary analysis of anchoring heuristics
Authors: Palacios-Delgado Jorge , Garduño Fabiola Aimeé Guerrero 
Published: December 2023

Abstract
Background
Preliminary evidence has been presented for interventions focused on preventing alcohol consumption or reducing the occurrence of episodes of excessive drinking. The anchoring text message intervention is a newly proposed theory-based approach to reducing heavy drinking among youth. The current study tests the preliminary efficacy of this intervention for reducing heavy drinking among Mexican youth.

Methods
Focusing on a sample of sixteen Mexican youths—nine not-heavy drinkers and seven heavy drinkers—the participants completed a survey on alcohol consumption and anchoring heuristics. Pretest and post-test questionnaire data were collected to evaluate the effectiveness of the intervention. The anchoring text messages consisted of strategies to limit alcohol use and feedback reminder messages. Assessments were conducted at baseline, four weeks of intervention, and post-intervention.

Results
Logistic regression analyses indicated a significant effect on heavy drinking episodes post-intervention. The post-intervention anchoring effects among the heavy drinker participants were different from those among the non-heavy drinkers in terms of reporting heavy drinking and future drinking. The anchoring heuristic-based intervention reduced the quantity of drinking and the future estimation of drinking and improved the ability to reject alcohol in the heavy drinker group.

Conclusions
These findings provide preliminary support for the effectiveness of the anchoring heuristic-based intervention, conducted through text messages sent by mobile phone to reduce alcohol consumption. The intervention promoted a reduction in alcohol consumption. Future research should be directed toward investigating the anchoring effects among heavy drinkers.
The toxic tango: TKI and ICI cardiotoxicities
Authors: Del Cid Fratti Juan , Paleru Vijayasree , Bajaj Madhuri , Bhardwaj Chetan 
Published: December 2023

Abstract
Background
Immune checkpoint inhibitors (ICI) and Tyrosine kinase inhibitors (TKI) are effective for several types of cancers, but they can have several cardiotoxicity sides effects. We present a case of TKI-ICI toxicity resulting in multiorgan inflammatory syndrome with myocarditis and thrombotic STEMI that were successfully treated with high-dose steroids and PCI.

Case presentation
Seventy-two year-old man patient treated with on pembrolizumab 200 mg IV every 3 weeks and Axitinib 5 mg PO q12h for the past 5 months complained of acute shortness of breath, altered mental status, and chronic diarrhea. Coronary angiography demonstrated a thrombotic lesion in the right coronary artery (RCA) that was treated successfully with percutaneous coronary intervention (PCI). Despite PCI he continued to complain of shortness of breath further workup with Cardiac MRI (CMR) was obtained showed an ejection fraction of 38%, small pericardial effusion, and delayed gadolinium enhancement (DGE) in the inferior wall suggestive of myocarditis. An empirical trial of high-dose steroids improved all patient symptoms and ejection fraction; therefore, the chemotherapy regimen was changed.

Conclusion
This case report highlights the potential vasculogenic effects of Axitinib and immune-related myocarditis of pembrolizumab. Cardiologists and oncologists should be vigilant for the cardiotoxic effects of Axitinib and pembrolizumab.