bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of dupilumab in pediatric patients with a nummular phenotype of atopic dermatitis
Authors: Kim Eun Jae , Hlobik Madeline , Ho Tina 
Published: February 2024

AbstractThe nummular phenotype of atopic dermatitis is clinically characterized by pruritic, coin‐shaped plaques that are frequently recalcitrant to treatment. In this study, a retrospective chart review was conducted to evaluate the effectiveness and safety of dupilumab in children with nummular lesions of dermatitis. Twelve out of 14 patients demonstrated significant clinical improvement at a median time of 2.5 months (interquartile range, 1–4) after dupilumab initiation. A single case of paradoxical psoriasiform eruption was the only side effect reported in our cohort.
Spaces of subsidiarity: A comparative inquiry into the social agenda of Cohesion Policy
Authors: Ballantyne Steven , Mascioli Lorenzo 
Published: February 2024

AbstractCohesion Policy—the European Union's (EU) policy platform for regional and local development—represents a major yet often neglected instance of Social Europe. In this article we inquire into the delivery of Cohesion Policy projects concerned with social policy objectives. Specifically, we ask: how are these projects delivered? Building on the literature of subsidiarisation in social policy, we theorise that the interaction of two processes—vertical subsidiarisation across territorial levels and horizontal subisidiarisation across sectoral levels—generates different spaces of subsidiarity, with major implications for policy outputs and outcomes. Empirically, we explore the emergence of spaces of subsidiarity in over 800 Cohesion Policy projects for quality employment and labour mobility delivered in Italy, Portugal, and Spain, during the 2010s. We show that, despite common rules, the governance framework through which the social agenda of Cohesion Policy is implemented is not a constant but a variable, one that may be leveraged by future research to explain the heterogeneous impact of Cohesion Policy across the EU. Our contribution is relevant to research on Social Europe, research on the territorial dimension of post‐industrial welfare systems as well as research on Cohesion Policy.
Effect of major trauma on the expected number of births in Finnish women: A nationwide population‐based public data and register analysis
Authors: Vaajala Matias , Kuitunen Ilari , Mattila Ville M. , Yazer Mark H. 
Published: February 2024

AbstractBackgroundThe effect of major trauma on subsequent fertility is poorly described. If women have lower fertility after trauma, they would have a lower risk of anti‐D mediated hemolytic disease of the fetus and newborn in a future pregnancy following the transfusion of RhD‐positive blood to RhD‐negative women during their resuscitation.Study Design and MethodsData was obtained from the Care Register for Health Care, National Medical Birth Register, and open access data from Statistic Finland to evaluate the effect of major trauma (traumatic brain injuries, spine, pelvic, hip/thigh fractures) on the age‐specific number of births during years 1998–2018. The total number of births before a specific maternal age for different trauma populations was calculated and these were compared to the corresponding number of births in the general population.ResultsThere were 50,923 injured women in this study. All injured women, including when analyzed by the nature of their injury, demonstrated lower expected numbers of births starting at approximately 28 years of age compared to the general population of women in Finland. At age 49, the expected number of births in the general population was approximately 1.8, whereas for all injured women 0.6, women with TBIs and spine fractures 0.6, women with pelvic fractures 0.5, and women with hip or thigh fractures 0.3.DiscussionInjured women are predicted to have lower fertility rates compared to the general population of Finnish women. The lower fertility rate should be considered when planning a blood product resuscitation strategy for injured women.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada
Authors: Murdock Anita , Bashar Sabrin , White Dawn , Uyaguari-Diaz Miguel , Farenhorst Annemieke , Kumar Ayush 
Published: February 2024

ABSTRACT

The microbiological content of water is an ongoing concern in First Nations communities in Canada. Many communities lack water treatment plants and continue to be under drinking water advisories. However, lack of access to treatment plants is only a part of the problem as poor water distribution systems also contribute to the failure to provide safe drinking water. Here, we studied the microbial diversity and antibiotic resistome from water stored in cisterns from two First Nations communities in Manitoba, Canada. We found that the cistern water contained a high number of bacteria and showed the presence of diverse antimicrobial resistance genes. Interestingly, the bacterial diversity and antimicrobial resistance genes varied considerably from that of the untreated source water, indicating that the origin of contamination in the cistern water came from within the treatment plant or along the delivery route to the homes. Our study highlights the importance of proper maintenance of the water distribution system in addition to access to water treatment facilities to ensure a supply of safe water to First Nations communities in Canada.

IMPORTANCE
The work described addresses a critical issue in First Nations communities in Canada—the microbiological content of water. Many of these communities lack access to water treatment plants and frequently experience drinking water advisories. This study focused on the microbial diversity and antibiotic resistome in water stored in cisterns within two First Nations communities in Manitoba, Canada. These findings reveal that cistern water, a common source of drinking water in these communities, contains a high number of bacteria and a wide range of antimicrobial resistance genes. This highlights a serious health risk as exposure to such water can lead to the spread of drug-resistant infections, posing a threat to the well-being of the residents.
K isomers in atomic nuclei
Authors: Walker P. M. , Kondev F. G. 
Published: February 2024

AbstractThe properties ofKisomers are reviewed. Energies and decay hindrance factors are considered in detail for selected isomers in the$$A \approx $$A≈ 160–190 region, focusing on pairing effects and the keyK-mixing mechanisms that influence$$\gamma $$γ-ray decay rates. The$$\beta $$β-decay ofKisomers is studied, indicating that, far from the valley of$$\beta $$βstability, high-K$$\beta $$β-decaying isomers will populate high-Kstates in the daughter nuclei. The challenges of revealing predicted, but as-yet undiscovered, long-lived isomers in the neutron-rich$$N \approx 116$$N≈116prolate–oblate shape transition region are highlighted, and the occurrence of oblate high-Kisomers is discussed. The 2015 multi-quasiparticleK-isomer table of Kondev, Dracoulis, and Kibédi is updated.
A new exploration tool in the search for native hydrogen and helium
Authors: Olivares Carolina , Findlay Jennifer , Kelly Ranald , Otto Simon , Norman Max , Cairns Michael 
Published: February 2024

Abstract
Native hydrogen and helium have been considered important resources in assisting the energy transition. Hydrogen and helium seeps have been reported worldwide, which may indicate large reserves within the subsurface. However, generation of hydrogen and helium is complex; poorly understood and constrained for both generation processes and migration. One source of native hydrogen is ultramafic rocks, which have experienced serpentinization together with water radiolysis. In contrast, helium generation occurs as the result of the radioactive decay of uranium and thorium present within radiogenically enriched basement. An exploration tool, dedicated to identifying areas with the geological settings and conditions favourable for native hydrogen and helium generation, has been developed and tested. Several databases have been created and integrated as part of this study (geological and geochemical generation models) to support and focus the search for both hydrogen and helium. Machine learning algorithms which extract value from geospatial data types for detecting various accumulations have been implemented. The first machine learning results demonstrate the significant value in integrating data and machine learning for high grading areas more conducive to accumulating hydrogen and helium.
Cultural Adaptation of Recipes
Authors: Cao Yong , Kementchedjhieva Yova , Cui Ruixiang , Karamolegkou Antonia , Zhou Li , Dare Megan , Donatelli Lucia , Hershcovich Daniel 
Published: February 2024

AbstractBuilding upon the considerable advances in Large Language Models (LLMs), we are now equipped to address more sophisticated tasks demanding a nuanced understanding of cross-cultural contexts. A key example is recipe adaptation, which goes beyond simple translation to include a grasp of ingredients, culinary techniques, and dietary preferences specific to a given culture. We introduce a new task involving the translation and cultural adaptation of recipes between Chinese- and English-speaking cuisines. To support this investigation, we present CulturalRecipes, a unique dataset composed of automatically paired recipes written in Mandarin Chinese and English. This dataset is further enriched with a human-written and curated test set. In this intricate task of cross-cultural recipe adaptation, we evaluate the performance of various methods, including GPT-4 and other LLMs, traditional machine translation, and information retrieval techniques. Our comprehensive analysis includes both automatic and human evaluation metrics. While GPT-4 exhibits impressive abilities in adapting Chinese recipes into English, it still lags behind human expertise when translating English recipes into Chinese. This underscores the multifaceted nature of cultural adaptations. We anticipate that these insights will significantly contribute to future research on culturally aware language models and their practical application in culturally diverse contexts.
Metric-Free Learning Network with Dual Relations Propagation for Few-Shot Aspect Category Sentiment Analysis
Authors: Zhao Shiman , Xie Yutao , Chen Wei , Wang Tengjiao , Yao Jiahui , Zheng Jiabin 
Published: February 2024

Abstract
Few-shot Aspect Category Sentiment Analysis (ACSA) is a crucial task for aspect-based sentiment analysis, which aims to detect sentiment polarity for a given aspect category in a sentence with limited data. However, few-shot learning methods focus on distance metrics between the query and support sets to classify queries, heavily relying on aspect distributions in the embedding space. Thus, they suffer from overlapping distributions of aspect embeddings caused by irrelevant sentiment noise among sentences with multiple sentiment aspects, leading to misclassifications. To solve the above issues, we propose a metric-free method for few-shot ACSA, which models the associated relations among the aspects of support and query sentences by Dual Relations Propagation (DRP), addressing the passive effect of overlapping distributions. Specifically, DRP uses the dual relations (similarity and diversity) among the aspects of support and query sentences to explore intra-cluster commonality and inter-cluster uniqueness for alleviating sentiment noise and enhancing aspect features. Additionally, the dual relations are transformed from support-query to class-query to promote query inference by learning class knowledge. Experiments show that we achieve convincing performance on few-shot ACSA, especially an average improvement of 2.93% accuracy and 2.10% F1 score in the 3-way 1-shot setting.
Defining “Crisis” in Migration Governance: a Critical Legal Mapping of EU Crisis Response Mechanisms
Authors: Campesi Giuseppe 
Published: February 2024

Abstract
Over the past ten years, the language of crisis has become increasingly common in discourse about migration governance at the European Union (EU) level, and policy responses have been oriented by an emergency rationale that prioritizes short-term solutions over long-term planning. EU migration and asylum law incorporates several crisis response mechanisms, and the addition of a new set of instruments has recently been proposed. This paper offers a critical legal mapping of what counts as a “crisis” in EU migration and asylum law, and the mechanisms for responding to such crises. It exemplifies a complex system in which the tension between the imperative to address threats purportedly arising from unwanted migration is intricately intertwined with the necessity of granting Member States flexibility to respond to contingencies without compromising the integrity of the common EU asylum and migration system.
Improving the effectiveness of CPR during interventional procedures
Authors: Gaisendrees Christopher , Eghbalzadeh Kaveh , Adam Matti , Djordjevic Ilija , Mehler Oliver , Wahlers Thorsten , Kuhn Elmar W 
Published: February 2024

Introduction The number of interventional procedures, such as transcatheter aortic valve replacements or thoracic endovascular aortic repairs, is on the rise. Intraprocedural cardiac arrest is a rare occurrence during high-risk procedures. Modern hybrid-operating tables may adversely affect chest compression quality due to their flexibility. To investigate this relationship, we analyzed the blood pressure generated during chest compressions at different degrees of table extension and assessed the effect of an additional stabilization bar to secure the table. Methods A CPR manikin was connected to online blood pressure monitoring on a hybrid operating table. Chest compressions were administered using a mechanical device (at 100 bpm and 80 bpm). Hemodynamic effects were evaluated at various degrees of table extension (0%, 50%, 100% table extension) and with the addition of a stabilization bar. Results A greater degree of table extension was associated with lower diastolic blood pressure. The addition of a stabilization bar alleviated this drop in diastolic blood pressure and enabled the generation of higher mean arterial pressures at 50% and 100% table extension during chest compressions. Conclusion The flexibility of a hybrid operating table adversely impacts the hemodynamic effect of chest compressions. This effect may be mitigated by using a stabilization bar. These results may be relevant for providing further recommendations for CPR guidelines in hybrid OR settings.
Tobramycin and Vancomycin in an In Vitro Model of Anterior Cruciate Ligament Allograft Decontamination
Authors: Bentkowski Brett N. , Blunt Koral M. , Milliron Eric M. , Cavendish Parker A. , Barnes Ryan H. , Kaeding Christopher C. , Magnussen Robert A. , Stoodley Paul , Flanigan David C. 
Published: February 2024

Background: Approximately 100,000 anterior cruciate ligament (ACL) reconstructions (ACLRs) occur annually in the United States, and postoperative surgical-site infection is a relatively rare but devastating complication, often leading to graft failure or septic arthritis of the knee, necessitating repeat surgery. Wrapping allografts in vancomycin-soaked gauze has been adopted as a common sterilization technique in the operating room to reduce surgical-site infection; however, identifying effective alternatives to vancomycin has not been extensively pursued. Hypothesis: Tobramycin would be as effective as vancomycin in reducing the concentrations of Staphylococcus epidermidis bacteria on tendon allografts. Study Design: Controlled laboratory study. Methods: S. epidermidis strain ATCC 12228 was inoculated onto the human cadaveric gracilis tendon. The tendons were wrapped in sterile gauze saturated with tobramycin or vancomycin at various experimental concentrations. Bacteria remaining on the tendon were dislodged, serially diluted, and plated for colony counting. Statistical analysis was performed utilizing 2-way analysis of variance testing. Results were considered statistically significant when P < .05. Results: Vancomycin ( P = .0001) and tobramycin ( P < .0001) reduced bacterial concentration. Tobramycin was found to produce a statistically significant reduction in bacterial concentration at concentrations as low as 0.1 mg/mL ( P < .0001 and P = .01 at 10 and 20 minutes), while vancomycin produced a statistically significant reduction at a concentration as low as 2.5 mg/mL ( P < .0001 at both 10 and 20 minutes). Conclusion: This study demonstrates that tobramycin is as effective as vancomycin in bacterial concentration reduction but can achieve this reduction level at lower doses. Further studies clarifying the biomechanical and cytotoxic effects of tobramycin on tendon tissue are indicated to solidify its use as a clinical alternative to vancomycin in ACLR. Clinical Relevance: These results will begin establishing tobramycin as an alternative to vancomycin in ACL graft decontamination. Because of relatively frequent shortages of vancomycin, establishing tobramycin as an alternative agent is a useful option for the orthopaedic surgeon.
Men’s Depression and Anxiety: Contributing Factors and Barriers to Intervention
Authors: Molewyk Doornbos Mary , Zandee Gail Landheer 
Published: February 2024

BACKGROUND: Urban, ethnically/racially diverse, impoverished men are predisposed to experience unaddressed depression and anxiety. The overlap of these factors creates significant mental health inequity. AIMS: This study sought to capture men’s impressions of the factors that contributed to their experience of depression and anxiety as well as barriers that they experienced in pursuing intervention. METHODS: Using community-based participatory research, in the context of long-term partnerships between a department of nursing and three urban, racially/ethnically diverse, and impoverished neighborhoods, the researchers recruited 50 men ages 23–83 years. Data were collected via six homogeneous, Zoom-based focus groups composed of Black, Hispanic, and White men, respectively. RESULTS: The men identified multiple themes pertaining to modifiable and non-modifiable contributing factors that played a role in their development of depression and anxiety as well as barriers related to stigma, resource issues, and a lack of knowledge of mental illness that they faced when seeking intervention. CONCLUSIONS: Understanding men’s perspectives on the contributing factors and barriers to mental health intervention can provide an evidence base with which to address mental health inequity via tailored care, policy, and research agendas.
The use of linked administrative data in Australian randomised controlled trials: A scoping review
Authors: Fahridin Salma , Agarwal Neeru , Bracken Karen , Law Stephen , Morton Rachael L 
Published: February 2024

Background/Aims: The demand for simplified data collection within trials to increase efficiency and reduce costs has led to broader interest in repurposing routinely collected administrative data for use in clinical trials research. The aim of this scoping review is to describe how and why administrative data have been used in Australian randomised controlled trial conduct and analyses, specifically the advantages and limitations of their use as well as barriers and enablers to accessing administrative data for use alongside randomised controlled trials. Methods: Databases were searched to November 2022. Randomised controlled trials were included if they accessed one or more Australian administrative data sets, where some or all trial participants were enrolled in Australia, and where the article was published between January 2000 and November 2022. Titles and abstracts were independently screened by two reviewers, and the full texts of selected studies were assessed against the eligibility criteria by two independent reviewers. Data were extracted from included articles by two reviewers using a data extraction tool. Results: Forty-one articles from 36 randomised controlled trials were included. Trial characteristics, including the sample size, disease area, population, and intervention, were varied; however, randomised controlled trials most commonly linked to government reimbursed claims data sets, hospital admissions data sets and birth/death registries, and the most common reason for linkage was to ascertain disease outcomes or survival status, and to track health service use. The majority of randomised controlled trials were able to achieve linkage in over 90% of trial participants; however, consent and participant withdrawals were common limitations to participant linkage. Reported advantages were the reliability and accuracy of the data, the ease of long term follow-up, and the use of established data linkage units. Common reported limitations were locating participants who had moved outside the jurisdictional area, missing data where consent was not provided, and unavailability of certain healthcare data. Conclusions: As linked administrative data are not intended for research purposes, detailed knowledge of the data sets is required by researchers, and the time delay in receiving the data is viewed as a barrier to its use. The lack of access to primary care data sets is viewed as a barrier to administrative data use; however, work to expand the number of healthcare data sets that can be linked has made it easier for researchers to access and use these data, which may have implications on how randomised controlled trials will be run in future.
Design of a Workshop for Focused Transesophageal Echocardiography During Noncardiac Surgery in Nurse Anesthesia Education
Authors: Swerdlow Barry , Osborne-Smith Lisa , Soelberg Julie 
Published: February 2024

OBJECTIVE The use of transesophageal echocardiography (TEE) by certified registered nurse anesthetists (CRNAs) during noncardiac surgery is relatively uncommon despite its unique potential to diagnose causes of hemodynamic instability. To address this problem, educational endeavors designed to provide practical TEE skills to CRNAs are needed. The aim of the current study was to evaluate the feasibility, acceptability, efficacy, and utility of a 2-day focused TEE workshop in nurse anesthesia education that employed a protocol involving a limited number of views and used goal-directed, qualitative assessments of critical physiologic parameters. METHODS This was a prospective, observational study involving 14 second-year nurse anesthesia students. The cohort was evaluated following completion of this workshop by simulator-based testing involving hypothetical clinical scenarios, and this test data was analyzed according to the percent successful acquisition and interpretation of TEE views to determine immediate objective teaching efficacy. The acceptability, perceived efficacy, and perceived utility of the workshop were assessed by online survey, and survey responses were qualitative and quantitative in nature. RESULTS Participants acquired appropriate TEE views associated with clinical scenarios 99% of the time and correctly interpreted the pathology in those views 93% of the time. Participants uniformly perceived significant educational value in this workshop and intend to incorporate TEE in their future clinical practice. CONCLUSIONS A 2-day workshop to teach focused TEE to nurse anesthesia trainees directed by a streamlined protocol is feasible, acceptable, and perceived as useful by participants, and provides practical experience and entry-level competency in this point-of-care ultrasound modality.