bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of Long-Term Spot Activity on Several Late-Spectral-Type Stars
Authors: Kozhevnikova A. V. , Alekseev I. Yu. , Kozhevnikov V. P. 
Published: December 2023

Abstract
We present our analysis of many-year photometry for several dozens of chromospherically active stars that exhibit solar-type activity (from our own observations as well as from data in the literature). Modeling of the distribution of cool photospheric spots, based on the zonal model, was performed, with several hundred models constructed. We find that, for most stars, their spots are located at intermediate and moderate latitudes and that the largest spotted areas can cover from 7 to 58% of the star’s surface. We demonstrate that a latitude drift of spots can be suspected for a number of stars, towards the equator as well as towards the pole; however, the rate of this drift is several times lower than for solar spots. For 15 stars, we detected the presence of activity cycles from 3 to 28 years long that reveal themselves in variations of the system’s brightness as well as in variations of the total spot coverage of the star. This paper is based on a talk presented at the memorial astrophysical workshop “Novelties in Understanding the Evolution of Binary Stars” dedicated to the 90th birthday of Prof. M.A. Svechnikov.
Parameter calibration of discrete element simulation for the interaction between heavy soil and soil-engaging components in shellfish culture
Authors: Huang Bing , Pan Hong , Wang Xiao-Meng , Li Yong-Ren , Zhang Tao , Li Shi-De , Jiang Yong-Cheng , Wang Fan-Zhen 
Published: December 2023

Shellfish culture heavy soils are suitable for the cultivation of marine organisms and are essential for the development of marine fisheries. To study both the interaction between heavy soil particles and that between the soil and soil-engaging components of agricultural machinery in shellfish culture, the simulation parameters in the model were determined. To study the interaction between soil particles in the viscous soil of shellfish culture with moisture content of 26.51% ± 1%. Discrete element method is used to establish the accumulation simulation experiment; the contact parameters between soil particles were calibrated. The response surface optimization technique was used to create the accumulation angle regression model. To study the interaction between the soil and soil-engaging components, the static friction coefficient between the heavy soil and soil-engaging components was determined by static friction experiment. The contact parameters between the soil and soil-engaging components were calibrated by the slope simulation experiment; the rolling distance regression model was established by response surface optimization methodology. The findings demonstrate that the optimized soil model can simulate the actual soil, and reflect the interaction between the heavy soil particles, soil, and the soil-engaging components of agricultural machinery, which not only provides a theoretical basis for the design and optimization of soil-engaging components of agricultural machinery in heavy soil, but also provides a new way for the research and development of agricultural machinery in a complex environment.
Surgical Treatment for Patients with Post-traumatic Flexion Contracture of Proximal Interphalangeal Joint: Analysis of Various Affecting Factors
Authors: LEE Jun-Ku , OH Chi Hoon , OH Jongbeom , JEONG Simho , LIM Chae Kwang , HAN Soo-Hong 
Published: December 2023

Background: A flexion contracture (FC) of the proximal interphalangeal (PIP) joint can have a profound negative influence on daily activity. The outcomes of surgical release of the PIP joint in literature are based on small sample size studies done several decades ago. The aim of this study is to report the outcomes of surgical treatment for post-traumatic FC of the PIP joint and to identify factors that affect these outcomes. Methods: This single institute retrospective study included patients from 2000 to 2020. We only included patients with post-traumatic FC of the PIP joint. We evaluated the demographic characteristics, cause of FC, surgical approaches and the various procedures conducted. We surveyed postoperative complications. During the study period, we asked about their current symptoms and evaluated their operative outcomes as excellent, good, fair or poor through the phone. Results: The average FC recovery angle was 37.3°. The small finger was the most affected, and the most common cause of FC was a tendon laceration. The volar plate complex release was the most frequently conducted procedure. The FC improvement was positively correlated to the degree of preoperative FC. The more severe preoperative flexion–extension arc was presented, the more FC recovery was achieved after operation. Patients who underwent multiple procedures had a higher degree of preoperative FC, and better correction was achieved with multiple procedures than with a single procedure. The most critical complication was recurrence. Conclusions: We were able to obtain average 37.3° of extension by surgical treatment. The more severe the FC presented before surgery, the greater the need for multiple procedures, however, this resulted in a significant increase in joint extension. Nevertheless, caution should be exercised regarding recurrence and could occur even with an experienced surgeon. Level of Evidence: Level IV (Therapeutic)
Index Finger Flexor Digitorum Profundus Function Deficit after Shoulder Arthroscopy Treated by Neurolysis: A Case Report
Authors: KIM Seong Hun , CHANG Min-Yung , CHOI Heemin , LEE Jun-Ku 
Published: December 2023

A 60-year-old woman presented functional deficit of the index finger flexor digitorum profundus (FDP) tendon after shoulder arthroscopic rotator cuff repair. As no recovery was observed for 10 months, we conducted an operative exploration of the median nerve and the anterior interosseous nerve, followed by an external neurolysis. The patient recovered FDP function 4.5 months after the second operation. In a patient with persistent isolated FDP dysfunction after shoulder arthroscopy, operative exploration and external neurolysis could facilitate functional recovery. Level of Evidence: Level V (Therapeutic)
The Relationship Between Neutrophil Lymphocyte Ratio (NLR) and The Smoking Status of Lung Cancer
Authors: Indah Sari Fitri , Setyawan Ungky , Destyana Dita 
Published: December 2023

Pendahuluan: Angka kematian yang tinggi dipengaruhi beberapa faktor risiko salah satunya rokok yang saat ini menjadi faktor risiko utama penyebab kanker paru. RNL dari darah lengkap perifer dapat menjadi bukti inflamasi sistemik dan indeks prognostik kanker. Penelitian terbaru menunjukkan bahwa RNL memiliki peran penting dalam respon imun terhadap kanker paru.
Tujuan: Tujuan penelitian ini adalah untuk mengetahui karakteristik pasien kanker paru berdasarkan usia, jenis kelamin, status merokok dan RNL di RSSA Malang dan hubungan antara RNL dengan status merokok pasien kanker paru di RSSA Malang.
Metode: Metode penelitian ini merupakan penelitian observasional analitik dengan menggunakan pendekatan desain penelitian cross-sectional. Metode penelitian ini merupakan penelitian observasional analitik dengan menggunakan pendekatan desain penelitian cross-sectional. Populasi penelitian ini adalah semua pasien yang terkonfirmasi kanker paru yang dirawat di RSUD Dr. Saiful Anwar Kota Malang pada bulan Januari 2021 hingga bulan Maret 2022. Data sampel merupakan data sekunder yang diambil dari rekam medis 40 pasien kanker paru di RSSA Malang. . Data yang diperoleh diinput ke excel. Setelah itu, dianalisis menggunakan SPSS. Data yang sudah diinput ke SPSS, dilakukan analisis diantaranya uji normalitas data (Saphirwo-Wilk), uji beda untuk mengetahui apakah ada nilai RNL yang signifikan pada pasien kanker digunakan Uji Independent T-Test, Uji Korelasi untuk mengetahui apakah terdapat hubungan antara RNL dengan status pasien kanker paru dengan ketentusn Uji Pearson apabila distribusi normal dan Uji Spearman apabila distribusi tidak normal.
Hasil: Hasil penelitian menunjukkan karakteristik subyek didominasi usia <60 tahun dimana status perokok lebih banyak terdata pada penelitian ini dengan jumlah 22 dengan jenis kelamin laki-laki lebih mendominasi dibandingkan perempuan dengan jumlah 24 dan lebih terdata sebagai perokok. Pada penelitian ini nilai RNL >3.53 lebih banyak ditemukan pada pasien kanker paru. Mean pada perokok memiliki nilai RNL yang lebih tinggi yaitu 4.821±3.88 sedangkan pada bukan perokok memiliki nilai 4.253±3.73.
Kesimpulan: Tidak terdapat perbedaan dan hubungan signifikan nilai RNL pada perokok dan bukan perokok.
Pasien COVID-19 dengan Cedera Hati Sedang dan Sindrom Gangguan Pernapasan Akut (ARDS)
Authors: Anjarwati Dwi , Putri Rifka , Rizqi Damar 
Published: December 2023

Pendahuluan: Penyakit coronavirus 2019 (COVID-19) masih berlangsung. Beberapa data menunjukkan bahwa penyakit ini menyerang berbagai organ, terutama pada kasus yang parah dan kritis. Kerusakan hati dan ARDS merupakan komplikasi yang sering terjadi pada pasien COVID-19. Tujuan penulisan makalah ini adalah untuk melaporkan dan mendiskusikan terapi pada kasus-kasus yang ditemukan oleh penulis sehingga diharapkan dapat bermanfaat secara klinis.
Ilustrasi kasus: Laki-laki 35 tahun dengan hasil swab nasofaring positif COVID-19 dengan kerusakan hati dan ARDS. Pasien mendapatkan protokol terapi standar pada saat perawatan di rumah sakit, plasma konvalesen 3 kolf dan terapi setelah perawatan di rumah sakit. Pasien telah membaik.
Diskusi: Menekan hiperaktivasi sitokin merupakan target utama dalam terapi COVID-19 agar tidak berkembang menjadi stadium yang lebih parah. Pemilihan favipiravir, colchicine, dexamethasone, UDCA, dan vitamin D adalah terapi yang menargetkan mekanisme ini.
Kesimpulan: Pasien dengan gejala berat hingga kritis berisiko mengalami kondisi yang lebih buruk bahkan kematian. Mengatasi hiperaktivasi sitokin merupakan target utama terapi kasus COVID-19, sehingga pemilihan obat yang digunakan didasarkan pada mekanisme patogenesis tersebut. Selain itu, pemberian terapi suportif lainnya juga perlu diperhatikan untuk penatalaksanaan yang lebih optimal.
Potential Long-Term Benefit of Home Systolic Blood Pressure Below 125 mm Hg for Cardiovascular Risk Reduction: The J-HOP Study Extended
Authors: Kario Kazuomi , Okawara Yukie , Kanegae Hiroshi , Hoshide Satoshi 
Published: December 2023

BACKGROUND:
The long-term benefit of achieving the Japanese Society of Hypertension home systolic blood pressure (SBP) target of <125 mm Hg has not been fully evaluated. This study investigated the long-term risk of cardiovascular disease events in individuals with home SBP <125 versus 125 to <135 or ≥135 mm Hg who participated in the J-HOP study (Japan Morning Surge-Home Blood Pressure).

METHODS:
The J-HOP study enrolled outpatients with ≥1 cardiovascular risk factor between 2005 and 2012, with follow-up until March 2015 and extended follow-up from December 2017 to May 2018. Cardiovascular disease events (stroke, coronary artery disease, congestive heart failure, and aortic dissection) were compared between home SBP subgroups.

RESULTS:
During mean 5.9 years of follow-up in 4231 participants (mean age, 65 years), cardiovascular events included stroke (n=89), coronary artery disease (n=116), congestive heart failure (n=37), and aortic dissection (n=8). The adjusted 10-year risk of total cardiovascular disease was slightly higher, and stroke risk was significantly higher when baseline home SBP was ≥135 versus <125 mm Hg (adjusted hazard ratio, 1.39 [95% CI, 0.97–2.00] for overall cardiovascular disease and 2.68 [95% CI, 1.34–5.38] for stroke; this was largely due to between-group differences in the first 5 years of follow-up, which were maintained over the subsequent 5 years). Findings were similar in the subgroup of high-risk patients (those with diabetes or stroke history).

CONCLUSIONS:
These data highlight the potential long-term benefit of strict home SBP control and validate this as an appropriate Japanese Society of Hypertension guideline target although confirmation in larger populations is needed.

REGISTRATION:
URL: XXX; University Hospital Medical Information Network Clinical Trials Registry; Unique identifier: UMIN000000894 (Japan Morning Surge-Home Blood Pressure study).
Genome-wide identification of CCO gene family in cucumber (Cucumis sativus) and its comparative analysis with A. thaliana
Authors: Akram Jannat , Siddique Riffat , Shafiq Muhammad , Tabassum Bushra , Manzoor Muhammad Tariq , Javed Muhammad Arshad , Anwar Samia , Nisa Bader Un , Saleem Muhammad Hamzah , Javed Bilal , Malik Tabarak , Mustafa Abd El-Zaher M. A. , Ali Baber 
Published: December 2023

AbstractCarotenoid cleavage oxygenase (CCO) is an enzyme capable of converting carotenoids into volatile, aromatic compounds and it plays an important role in the production of two significant plant hormones, i.e., abscisic acid (ABA) and strigolactone (SL). The cucumber plant genome has not been mined for genomewide identification of the CCO gene family. In the present study, we conducted a comprehensive genome-wide analysis to identify and thoroughly examine the CCO gene family within the genomic sequence of Cucumis sativus L. A Total of 10 CCO genes were identified and mostly localized in the cytoplasm and chloroplast. The CCO gene is divided into seven subfamilies i.e. 3 NCED, 3 CCD, and 1 CCD-like (CCDL) subfamily according to phylogenetic analysis. Cis-regulatory elements (CREs) analysis revealed the elements associated with growth and development as well as reactions to phytohormonal, biotic, and abiotic stress conditions. CCOs were involved in a variety of physiological and metabolic processes, according to Gene Ontology annotation. Additionally, 10 CCO genes were regulated by 84 miRNA. The CsCCO genes had substantial purifying selection acting upon them, according to the synteny block. In addition, RNAseq analysis indicated that CsCCO genes were expressed in response to phloem transportation and treatment of chitosan oligosaccharides. CsCCD7 and CsNCED2 showed the highest gene expression in response to the exogenous application of chitosan oligosaccharides to improve cold stress in cucumbers. We also found that these genes CsCCD4a and CsCCDL-a showed the highest expression in different plant organs with respect to phloem content. The cucumber CCO gene family was the subject of the first genome-wide report in this study, which may help us better understand cucumber CCO proteins and lay the groundwork for the gene family's future cloning and functional investigations.
The effect of cognitive-behavioral therapy and haptonomy on fear of childbirth in primigravida women: a randomized clinical trial
Authors: Alivand Zahra , Nourizadeh Roghaiyeh , Hakimi Sevil , Esmaeilpour Khalil , Mehrabi Esmat 
Published: December 2023

Abstract
Background
Considering the role of fear of childbirth (FOC) in the enhancement of unnecessary cesarean sections (CS), the present study aimed at evaluating the effect of Cognitive-Behavioral Therapy (CBT) and haptonomy on the FOC (as primary outcome) and intended birth method and final birth method (as secondary outcomes) among primigravida women.

Methods
This randomized clinical trial was conducted on 99 primigravida women in Tabriz, Iran 2022. Participants were assigned to three groups with a ratio of 1:1:1 using stratified block randomization based on the fear intensity. One of the intervention groups (n = 33) received eight group sessions of CBT from 24 to 28 weeks of gestation and the other intervention group (n = 33) received haptonomy during seven sessions once a week. The control group (n = 33) received routine prenatal care. The Wijma questionnaire was completed by the participants before the intervention, after the intervention at 35–37 weeks of gestation, and after birth. The intended birth method was investigated before and after the intervention at 35–37 weeks of gestation. The final birth method and the reasons for CS were recorded based on the mother’s medical profile. The one-way ANOVA was used before the intervention and RMANOVA after the intervention to compare the mean scores of FOC among the three groups. Further, chi-square test was applied to compare the intended and final birth method.

Results
The mean (standard deviation: SD) of FOC in the CBT group changed from 74.09 (11.35) at 24–28 weeks of gestation to 46.50 (18.28) at 35–37 weeks and 48.78 (20.64) after birth (P < 0.001). The means (SDs) of FOC in the haptonomy group were 76.81 (13.09), 46.59 (15.81), and 45.09 (20.11), respectively (P < 0.001). The mean (SD) of FOC in the control group decreased from 70.31 (6.71) to 66.56 (18.92) and then, increased to 71.00 (21.14) after birth (P = 0.878). After the intervention, there was no statistically significant difference among the three groups in terms of the intended birth method (P = 0.278), and final birth method (P = 0.107).

Conclusion
The findings of the present study revealed that both CBT and haptonomy interventions reduce FOC. Although the desire for vaginal birth and final vaginal birth in the haptonomy group was more than that in the other two groups, there was no statistically significant difference among the three groups.

Trial registration
Iranian Registry of Clinical Trials: IRCT20170506033834N9. Date of registration: 02.01.2022. URL: http://en.irct.ir.
Comparative analysis of external locking plate and combined frame external fixator for open distal tibial fractures: a comprehensive assessment of clinical outcomes and financial implications
Authors: Bangura Mohamed Lamin , Luo Huasong , Zeng Teng , Wang Minglu , Lin Shangce , Chunli Liang 
Published: December 2023

Abstract
Background
Open distal tibial fractures pose significant challenges regarding treatment options and patient outcomes. This retrospective single-centre study aimed to compare the stability, clinical outcomes, complications, and financial implications of two surgical interventions, namely the external locking plate and the combined frame external fixator, to manage open distal tibial fractures.

Methods
Forty-four patients with distal open tibial (metaphyseal extraarticular) fractures treated between 2020 and 2022 were selected and formed into two main groups, Group A and Group B. Group A (19 patients) are patients that underwent treatment using the external locking plate technique, while Group B (25 patients) received the combined frame external fixator approach. Age, gender, inpatient stay, re-operation rates, complications, functional recovery (measured by the Johner-Wrush score), pain ratings (measured by the Visual Analogue Scale [VAS]), and cost analyses were evaluated for each group. Statistical analyses using SPSS were conducted to compare the outcomes between the two groups.

Results
The research found significant variations in clinical outcomes, complications, and cost consequences between Group A and Group B. Group A had fewer hospitalisation periods (23.687.74) than Group B (33.5619.47). Re-operation rates were also considerably lower in Group A (26.3%) than in Group B (48%), owing to a greater prevalence of pin-tract infections and subsequent pin loosening in the combination frame external fixator group. The estimated cost of both techniques was recorded and analysed with the locking average of 26,619.69 ± 9,602.352 and the combined frame average of 39,095.64 ± 20,070.077.

Conclusion
This study suggests that although the two approaches effectively manage open distal tibia fractures, the locking compression plate approach (Group A) has an advantage in treating open distal tibia fractures. Shorter hospitalisation times, reduced re-operation rates, and fewer complications will benefit patients, healthcare systems, and budget allocation. Group A's functional recovery results demonstrate the locking plate technique's ability to improve recovery and patient quality of life. According to the cost analysis, the locking plate technique's economic viability and cost-effectiveness may optimise healthcare resources for open distal tibia fractures. These findings might improve patient outcomes and inform evidence-based orthopaedic surgery.
Sweet-type star fruit supplementation controls oxidative stress status and enhances the community walking capacity among elderly Thai
Authors: Kaju Jynwara , Leelarungrayub Jirakrit , Natakankitkul Surapol , Laskin James J 
Published: December 2023

Abstract
Background
Sweet-type Star fruit (SF) (Averrhoa carambola L.) is seasonal and more available for purchase in many markets in Thailand, when compared to the sour-type. But, its antioxidant activity results and potentially more modified supplement for elderly health during regular exercise in the community are unclear.

Objective
This study aimed to evaluate the antioxidant activity and physical capacity from supplementation of sweet-type SF among elderly people performing home walking exercise.

Methods
Mixing SF juice with honey industrially prepared the SF product. Its effects on oxidative stress status and physical capacity were studied in four groups; a supplement with walking exercise (n = 11, 67.00 ± 4.17 years), control (n = 12, aged 67.50 ± 5.58 years), supplementation (n = 11, aged 69.63 ± 7.14 years), and walking exercise (n = 12, aged 67.91 ± 4.33 years). Twenty grams or two teaspoons of supplement in warm water (150 mL) was the guideline for consumption twice daily for 4 weeks. In contrast, the walking exercise was prescribed with moderate intensity for 30 min, 3 days per week. Before and after the 4-week period, the oxidative stress status; glutathione (GSH), ascorbic acid (Vit C), total antioxidant capacity (TAC), and malondialdehyde (MDA), and 6-minute walking distance (6MWD) were evaluated.

Results
Results after the 4-week period, showed that Vit C and TAC increased and the MDA decreased significantly in the supplementation group, except the GSH and 6MWD results. The GSH and Vit C slightly decreased in the walking exercise group, whereas, its TAC, MDA and 6MWD increased significantly. Finally, The GSH and Vit C did not decrease and MDA slightly decreased in the combined group, but, their TAC and 6MWD increased significantly.

Conclusion
Supplementation of the SF product during walking exercise possibly controls oxidative stress status and may enhance walking capacity.
Hypoxia-mimetic by CoCl2 increases SLC7A5 expression in breast cancer cells in vitro
Authors: Canhasi Leonora , Tina Elisabet , Eremo Anna Göthlin 
Published: December 2023

Abstract
Objective
Increased expression of the amino acid transporter solute Carrier Family 7 Member 5 (SLC7A5) has been observed in neoplastic cells during hypoxic conditions in vitro, indicating an adaptation for cell survival. To further explore this, we evaluated hypoxia-mimetic by CoCl2 as a model for hypoxia in breast cancer cell lines and the effect on SLC257A5 expression. Four different breast cancer cell lines (MCF7, T-47D, BT-474 and ZR-75-1) were exposed to 100 µM CoCl2 for 48 h. Subsequently, cell viability, gene- and protein expression analyses were performed.

Results
The gene expression of VEGF, a marker of hypoxia, was significantly elevated in all four cell lines compared to the control (p < 0.0001), indicating that CoCl2 exposure generates a hypoxic response. Moreover, CoCl2 exposure significantly upregulated SLC7A5 gene expression in T-47D (p < 0.001), BT-474 (p < 0.0001) and ZR-75-1 (p < 0.0001) cells, as compared to vehicle control. Immunofluorescence staining showed increased SLC7A5 protein expression in MCF7, T-47D and BT-474 cells compared to vehicle control. This report suggests that hypoxia-mimetic by CoCl2 can be used as a simple model for inducing hypoxia in breast cancer cell lines and in fact influence SLC7A5 gene and protein expression in vitro.