bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decentralization in France
Authors: DE MONTRICHER NICOLE 
Published: March 2005

In France decentralization of the government was part of the socialist platform for the 1981 presidential election. The issue was immediately put on the agenda by the minister in charge of “interior and decentralization.” The law was published on March 2nd 1982. Ten years later, decentralization is considered a decisive reform toward the modernization of the state. Local governments are engaged in the process of learning the politics of autonomy. But the law maintained the prefet. Therefore the institutional pattern establishes two authorities in charge of the same territory at the level of “département” and “région.” It could be said that the goal of the 1982 reform was to authorize the expression of a local demand while the equality and qualify of public services would be preserved, thanks to deconcentration of the national apparatus. This scheme implies dramatic changes both in the local political system and in the national bureaucracy. The latest is reluctant to assess the evolution.In 1994 public administration in France is in transition. Its centralized structure and rationale has offen led to strategies directed toward the conservation of the old habits and privileges. The role of the prefect is still unsettled. Perhaps more important, serious institutional limits have been imposed on the process of change.
Victorian Emergency Minimum Dataset: Factors that impact upon the data quality
Authors: Marson Rebecca , Taylor David McD , Ashby Karen , Cassell Erin 
Published: March 2005

AbstractObjective:  The Victorian Emergency Minimum Dataset (VEMD) records details of approximately 80% of Victoria's ED presentations. Its usefulness for quality assurance and research relies on the data being both complete and accurate. We aimed to determine the factors that impact adversely on the collection of high‐quality VEMD data.Methods:  The study was a voluntary, anonymous, cross‐sectional survey of a range of ED staff (medical, nursing, clerical) who collect and enter data into the VEMD. Nine of the 28 hospitals that contribute to the VEMD were surveyed. The questionnaire was purpose‐designed and self‐administered.Results:  A total of 218 staff participated (response rate 95%). Six different software types were used, with 40% of respondents using the Pickware (MCAT) system. There was no consistency of ED personnel for the completion of specific data fields. One hundred and twenty‐six (56%) respondents had heard of the VEMD, 67 (29%) had had its structure and purpose explained and 65 (30%) had been trained to enter data. Ninety‐seven (45%) respondents knew what the VEMD data was used for, 38 (17%) knew they could request VEMD data for their own use and 17 (7.8%) had done so. Time constraints, software problems and lack of formal orientation and training in data entry were reported as the most important factors impacting adversely upon quality data entry.Conclusion:  Staff knowledge of the VEMD system and its uses are poor. Numerous factors impact on the quality of data entered and interventions aimed at improving staff education, training and feedback and software are indicated.
Trauma bypass in south‐eastern Sydney: An 8‐year review
Authors: Macken Lewis , Manovel Alvaro 
Published: March 2005

AbstractObjective:  The New South Wales (NSW) Health Department and the Ambulance Service of NSW introduced a trauma bypass system in Sydney on 29 March 1992. This study aims to review the outcomes of trauma bypass patients brought to St George Hospital, a major trauma service in south‐eastern Sydney, and to assess the performance of the current prehospital trauma triage protocol.Methods:  The St George Hospital Department of Trauma Services prospectively collected data on all trauma bypass patients for the 8‐year period from 29 March 1992 to 29 March 2000.Results:  A total of 1990 patients were brought to hospital on trauma bypass. The average age was 32 years, 70% were men and 66% were from road traffic accidents. The positive predictive value of the prehospital triage tool for serious injury (Injury Severity Score [ISS] > 15) was 18.6% (95% CI 16.9–20.4). This is well below the benchmark previously established by the NSW Health Department Trauma System Advisory Committee. For all trauma bypass patients, 33.8% (95% CI 31.7–35.9) were discharged home from the ED. The overall death rate was 2.5% (95% CI 1.9–3.3).Conclusions:  According to the proposed benchmark, current prehospital trauma triage guidelines are underperforming. This suggests that a review of the benchmarks of current local trauma systems and of the trauma triage tool is required.
The Kinematic Structure of a Wasatch Mountain Winter Storm during IPEX IOP3
Authors: Cox Justin A. W. , Steenburgh W. James , Kingsmill David E. , Shafer Jason C. , Colle Brian A. , Bousquet Olivier , Smull Bradley F. , Cai Huaqing 
Published: March 2005

Abstract
The influence of orographic circulations on the precipitation structure of a Wasatch Mountain winter storm is examined using observations collected during the third intensive observing period (IOP3) of the Intermountain Precipitation Experiment (IPEX). The event featured the passage of a midlevel (700–550 hPa) trough followed 3 h later by a surface trough. Prior to and during the midlevel trough passage, large-scale southwesterly flow impinged on the Wasatch Mountains. Low-level confluence was observed between this southwesterly flow and along-barrier southerly flow within 20–40 km of the Wasatch Mountains. This confluence zone, which moved toward the Wasatch Mountains during and following the passage of the midlevel trough, was accompanied by low-level convergence and precipitation enhancement over the upstream lowlands. Dual-Doppler analysis revealed the presence of a shallow along-barrier jet near the base of the Wasatch Mountains that was surmounted by southwesterly cross-barrier flow at mid- and upper-mountain levels. This cross-barrier flow produced strong (1–2 m s−1) ascent as it interacted with the steep windward slopes of the Wasatch Mountains, where precipitation was roughly double that observed in the lowlands upstream. Flow deflection and splitting were also observed near the highest terrain features. A narrow region of strong subsidence, which at times exceeded 2 m s−1, was found to the lee of the Wasatch and, based on radar imagery, appeared to modulate hydrometeor spillover aloft. Processes contributing to the evolution of the near-barrier flow field, including topographic blocking, diabatic effects, and surface friction contrasts, are discussed.
Simulation of the Intraseasonal Variance of the South American Summer Monsoon
Authors: Misra Vasubandhu 
Published: March 2005

Abstract
This study reveals the inadequacy of the Center for Ocean–Land–Atmosphere Studies (COLA) atmospheric general circulation model (AGCM) and the National Centers for Environmental Prediction–National Center for Atmospheric Research (NCEP–NCAR) reanalysis to resolve the variance of the intraseasonal anomalies of outgoing longwave radiation (OLR) over the South American summer monsoon (SASM) domain and the equatorial eastern Pacific Ocean (EEPO) owing to their coarse horizontal resolution. However, when the NCEP–NCAR reanalysis is downscaled by roughly a factor of 2.5 using the Regional Spectral Model (RSM; control-A experiment), the simulation of the seasonal mean variance of intraseasonal anomalies of OLR improves significantly. But downscaling the results of the COLA AGCM (control-B experiment) by roughly a factor of 4 led to no further improvement.
Using the novel technique of anomaly nesting, which replaces the climatology of the COLA AGCM of the nested variables at the lateral boundaries of the RSM with the NCEP–NCAR reanalysis climatology (AN experiment), the simulation of the intraseasonal variance of OLR improves significantly over control-B runs. This improvement is shown to coincide with a distinct diurnal variation of the intraseasonal scales displayed in the AN integrations, which compare reasonably well with control-A integrations. A disappointing result of this study is that the generated variance of intraseasonal anomalies of OLR in the AN integrations arises from the internal variability of the model. However, it is concluded that the systematic errors of the COLA AGCM imposed on RSM from the lateral boundary conditions suppress the generation of intraseasonal variability.
The Spoken Knowledge in Low Literacy in Diabetes Scale
Authors: Rothman Russell L. , Malone Robb , Bryant Betsy , Wolfe Catherine , Padgett Penelope , DeWalt Darren A. , Weinberger Morris , Pignone Michael 
Published: March 2005

Purpose The purpose of this study was to develop and validate a new knowledge scale for patients with type 2 diabetes and poor literacy: the Spoken Knowledge in Low Literacy patients with Diabetes (SKILLD). Methods The authors evaluated the 10-item SKILLD among 217 patients with type 2 diabetes and poor glycemic control at an academic general medicine clinic. Internal reliability was measured using the Kuder-Richardson coefficient. Performance on the SKILLD was compared to patient socioeconomic status, literacy level, duration of diabetes, and glycated hemoglobin (A1C). Results Respondents’ mean age was 55 years, and they had diabetes for an average of 8.4 years; 38% had less than a sixth-grade literacy level. The average score on the SKILLD was 49%. Less than one third of patients knew the signs of hypoglycemia or the normal fasting blood glucose range. The internal reliability of the SKILLD was good (0.72). Higher performance on the SKILLD was significantly correlated with higher income (r= 0.22), education level (r= 0.36), literacy status (r= 0.33), duration of diabetes (r= 0.30), and lower A1C (r= –0.16). When dichotomized, patients with low SKILLD scores (= 50%) had significantly higher A1C (11.2% vs 10.3%, P< .01). This difference remained significant when adjusted for covariates. Conclusion The SKILLD demonstrated good internal consistency and validity. It revealed significant knowledge deficits and was associated with glycemic control. The SKILLD represents a practical scale for patients with diabetes and low literacy.
Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses
Authors: Risueño Ruth M. , Gil Diana , Fernández Edgar , Sánchez-Madrid Francisco , Alarcón Balbino 
Published: March 2005

Abstract
Triggering of the T-cell receptor (TCR) can produce very different responses, depending on the nature of the major histocompatibility complex/antigen peptide (MHCp) ligand. The molecular mechanisms that permit such fine discrimination are still unknown. We show here that an epitope in the cytoplasmic tail of the TCR CD3ϵ subunit, recognized by antibody APA1/1, is only detected when the TCR is fully activated. Exposure of the APA1/1 epitope is shown to be fast and independent of tyrosine kinase activity and that it takes place even when T cells are stimulated at 0°C. These results suggest that APA1/1 detects a conformational change in the TCR. APA1/1 staining concentrates in a restricted area of the immunologic synapse. Most important, we show that full agonist, but not partial agonist, peptides induce exposure of the APA1/1 epitope, indicating a correlation between the induction of the conformational change in the TCR and full T-cell activation. Finally, the conformational change is shown to occur in T cells that are being stimulated by antigen in vivo. Therefore, these results demonstrate that the TCR undergoes a conformational change on MHCp binding in vitro and in vivo, and they establish a molecular correlate for productive TCR engagement. (Blood. 2005;106:601-608)
Diabetes-prone NOD mice show an expanded subpopulation of mature circulating monocytes, which preferentially develop into macrophage-like cells in vitro
Authors: Nikolic Tatjana , Bouma Gerben , Drexhage Hemmo A , Leenen Pieter J M 
Published: March 2005

AbstractIn the nonobese diabetic (NOD) mouse, a model of autoimmune diabetes, dendritic cells (DC), and macrophages (Mφ) is important for the initiation and progression of autoimmunity and the final destruction of β-cells. Previous studies suggested that an aberrant development of DC and Mφ is related to their pathogenic function. To study this in vivo, we investigated NOD mouse monocytes, the direct precursors of DC, and Mφ. The recently described discrimination between immature (Ly-6Chigh) and mature (Ly-6Clow) monocytes enabled us to investigate the apportioning between blood monocyte populations in the NOD mouse, which had an abnormally high number of mature monocytes in circulation, and this phenomenon appeared to be intrinsic to the NOD background, as nonobese resistant (NOR) and NOD-H2b mice also showed this altered balance. After depletion by apoptosis-inducing liposomes, the reappearance and transition of immature-to-mature monocytes had similar kinetics as control mice but led again to the presence of a larger, mature monocyte compartment in the blood. In addition, although monocytes from C57BL mice down-regulated their capability to adhere to fibronectin and intercellular adhesion molecule-1 upon maturation, the mature NOD monocytes retained their high adhesion capacity, characteristic of immature cells. Furthermore, both monocyte subpopulations of NOD mice showed enhanced differentiation into Mφ-like F4/80high cells in vitro. In conclusion, mice with the NOD background have raised numbers of mature monocytes in the circulation and a proinflammatory, Mφ-directed monocyte development.
Analysis of xbx genes in C. elegans
Authors: Efimenko Evgeni , Bubb Kerry , Mak Ho Yi , Holzman Ted , Leroux Michel R. , Ruvkun Gary , Thomas James H. , Swoboda Peter 
Published: March 2005

Cilia and flagella are widespread eukaryotic subcellular components that are conserved from green algae to mammals. In different organisms they function in cell motility, movement of extracellular fluids and sensory reception. While the function and structural description of cilia and flagella are well established, there are many questions that remain unanswered. In particular, very little is known about the developmental mechanisms by which cilia are generated and shaped and how their components are assembled into functional machineries. To find genes involved in cilia development we used as a search tool a promoter motif, the X-box, which participates in the regulation of certain ciliary genes in the nematode Caenorhabditis elegans.
By using a genome search approach for X-box promoter motif-containing genes(xbx genes) we identified a list of about 750 xbx genes(candidates). This list comprises some already known ciliary genes as well as new genes, many of which we hypothesize to be important for cilium structure and function. We derived a C. elegans X-box consensus sequence by in vivo expression analysis. We found that xbx gene expression patterns were dependent on particular X-box nucleotide compositions and the distance from the respective gene start. We propose a model where DAF-19, the RFX-type transcription factor binding to the X-box, is responsible for the development of a ciliary module in C. elegans, which includes genes for cilium structure, transport machinery, receptors and other factors.
Effect of dietary fatty acid composition on depot fat and exercise performance in a migrating songbird, the red-eyed vireo
Authors: Pierce Barbara J. , McWilliams Scott R. , O'Connor Timothy P. , Place Allen R. , Guglielmo Christopher G. 
Published: March 2005

SUMMARYMost migrating birds accumulate lipid stores as their primary source of energy for fueling long distance flights. Lipid stores of birds during migration are composed of mostly unsaturated fatty acids; whether such a fatty acid composition enhances exercise performance of birds is unknown. We tested this hypothesis by measuring metabolic rate at rest and during intense exercise in two groups of red-eyed vireos, a long-distance migratory passerine, fed either a diet containing 82% unsaturated fat (82%U), or one containing 58% unsaturated fat (58%U). Vireos fed the 82%U diet had fat stores containing (77%) unsaturated fatty acids, whereas vireos fed the 58% U diet had fat stores containing less (66%) unsaturated fatty acids. Blood metabolites measured prior to and immediately following exercise confirmed that vireos were metabolizing endogenous fat during intense exercise. Mass-specific resting metabolic rate (RMR) was similar for vireos fed the 58%U diet (2.75±0.32 ml O2 g–1h–1) and for vireos fed the 82%U diet (2.30±0.30 ml O2 g–1 h–1). However,mass-specific peak metabolic rate (MRpeak) was 25% higher in vireos fed the 58%U diet (28.55±1.47 ml O2 g–1h–1) than in vireos fed the 82%U diet (21.50±1.76 ml O2 g–1 h–1). Such whole-animal energetic effects of fatty acid composition of birds suggest that the energetic cost of migration in birds may be affected by the fatty acid composition of the diet.
Testing the hindlimb-strength hypothesis: non-aerial locomotion by Chiroptera is not constrained by the dimensions of the femur or tibia
Authors: Riskin Daniel K. , Bertram John E. A. , Hermanson John W. 
Published: March 2005

SUMMARYIn the evolution of flight bats appear to have suffered a trade-off; they have become poor crawlers relative to terrestrial mammals. Capable walking does occur in a few disparate taxa, including the vampire bats, but the vast majority of bats are able only to shuffle awkwardly along the ground, and the morphological bases of differences in crawling ability are not currently understood. One widely cited hypothesis suggests that the femora of most bats are too weak to withstand the compressive forces that occur during terrestrial locomotion, and that the vampire bats can walk because they possess more robust hindlimb skeletons. We tested a prediction of the hindlimb-strength hypothesis: that during locomotion, the forces produced by the hindlimbs of vampire bats should be larger than those produced by the legs of poorly crawling bats. Using force plates we compared the hindlimb forces produced by two species of vampire bats that walk well, Desmodus rotundus(N=8) and Diaemus youngi (N=2), to the hindlimb forces produced during over-ground shuffling by a similarly sized bat that is a poor walker (Pteronotus parnellii; N=6). Peak hindlimb forces produced by P. parnellii were larger (ANOVA; P&lt;0.05; N=65) and more variable (93.5±36.6% body weight, mean ± s.d.) than those of D. rotundus(69.3±8.1%) or D. youngi (75.0±6.2%). Interestingly,the vertical components of peak force were equivalent among species(P&gt;0.6), indicating similar roles for support of body weight by the hindlimbs in the three species.We also used a simple engineering model of bending stress to evaluate the support capabilities of the hindlimb skeleton from the dimensions of 113 museum specimens in 50 species. We found that the hindlimb bones of vampires are not built to withstand larger forces than those of species that crawl poorly. Our results show that the legs of poorly crawling bats should be able to withstand the forces produced during coordinated crawling of the type used by the agile vampires, and this indicates that some mechanism other than hindlimb bone thickness, such as myology of the pectoral girdle, limits the ability of most bats to crawl.
A novel diuretic hormone receptor inDrosophila: evidence for conservation of CGRP signaling
Authors: Johnson Erik C. , Shafer Orie T. , Trigg Jennifer S. , Park Jae , Schooley David A. , Dow Julian A. , Taghert Paul H. 
Published: March 2005

SUMMARYThe Drosophila orphan G protein-coupled receptor encoded by CG17415 is related to members of the calcitonin receptor-like receptor (CLR) family. In mammals, signaling from CLR receptors depend on accessory proteins, namely the receptor activity modifying proteins (RAMPs)and receptor component protein (RCP). We tested the possibility that this Drosophila CLR might also require accessory proteins for proper function and we report that co-expression of the mammalian or Drosophila RCP or mammalian RAMPs permitted neuropeptide diuretic hormone 31 (DH31) signaling from the CG17415 receptor. RAMP subtype expression did not alter the pharmacological profile of CG17415 activation. CG17415 antibodies revealed expression within the principal cells of Malpighian tubules, further implicating DH31 as a ligand for this receptor. Immunostaining in the brain revealed an unexpected convergence of two distinct DH signaling pathways. In both the larval and adult brain, most DH31 receptor-expressing neurons produce the neuropeptide corazonin, and also express the CRFR-related receptor CG8422, which is a receptor for the neuropeptide diuretic hormone 44 (DH44). There is extensive convergence of CRF and CGRP signaling within vertebrates and we report a striking parallel in Drosophila involving DH44 (CRF) and DH31 (CGRP). Therefore, it appears that both the molecular details as well as the functional organization of CGRP signaling have been conserved.
Dynamical (harmonic) interface stress field in the half-plane covered by the prestretched layer under a strip load
Authors: Akbarov S D , Guler C 
Published: March 2005

Within the framework of the piecewise homogeneous body model, by employing the three-dimensional linearized theory of elastic waves in initially stressed bodies the dynamical problem of the stress distribution in a half-plane covered with a prestretched layer is investigated. It is assumed that the free face plane of the covered layer is subjected to a uniformly distributed harmonic load acting on a strip extending to infinity in the x3 direction, which is perpendicular to the x1-x2 plane and is of width 2a in the x1 direction. The plane-strain state in the x1-x2 plane is analysed. The corresponding boundary-value problems are investigated by employing the exponential Fourier integral transformation. The numerical results regarding the interface normal stress distribution are presented. The influences of the problem parameters and pre-stretching of the covered layer on this distribution are analysed. Practical engineering application fields of the results are suggested.
Studies on mechanical and thermal properties of ternary blends of polyethylenes. I
Authors: Srivastava Deepak 
Published: March 2005

AbstractSix film samples of varying compositions of linear low‐density polyethylene (LLDPE), 10–35 wt %, and high‐density polyethylene (HDPE), 40–65 wt %, having a fixed percentage of low‐density polyethylene (LDPE) at 25 wt % were extruded by melt blending in a single‐screw extruder (L/D ratio = 20 : 1) of uniform thickness of 2 mil. The tensile strength, elongation at break, and impact strength were found to increase up to 60 wt % HDPE addition, starting from 40 wt % HDPE, in the blends and then decreased. The blend sample B‐500 was found to be more thermally stable than its counterparts. The appearance of a single peak beyond 45 wt % HDPE content in the blend in dynamic DSC scans showed the formation of miscible blend systems and this was further confirmed by scanning electron microscopic analysis. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 1691–1698, 2005
Effect of nanosized calcium carbonate on the mechanical properties of latex films
Authors: Manroshan S. , Baharin A. 
Published: March 2005

AbstractAn acrylic dispersed nanosized calcium carbonate filler was added to a prevulcanized latex compound in different amounts. The effect of filler content on the curing time, modulus, tensile strength, elongation at break (Eb) before and after ageing, and the morphology of the films was investigated. Results showed that the curing time decreased with filler loading because of the increased interaction between the filler and rubber matrix, as reflected by the decrease in the apparent swelling index. Modulus at 100% elongation and modulus at 300% elongation increased with filler loading. Tensile strength and Eb increased up to 10 phr of filler loading and then decreased again. Aged films showed improved mechanical properties compared to those of unaged films. Micrographs showed that agglomeration occurred as the filler content was increased. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 1550–1556, 2005