bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of hesperidin on deltamethrin toxicity in rat periodontal membrane
Authors: İpek Fikret , Deveci Engin , İpek Polat 
Published: October 2023

Aim: Deltamethrin (DM), a hydrophobic and lipophilic substance used for insect control, easily accumulates in the body, increasing ROS production and causing mucosal inflammation and damage. The aim of this study was to explore the prophylactic effects of hesperidin on DM toxicity in periodontal membrane.
Methods: The study was conducted for 14 days on 21 male Wistar albino rats. The experimental animals were divided into three groups (n=7): The Sham group received 0.9% NaCl (1 mL). The deltamethrin group received 0.5 mg/kg DM (1 mL, dissolved in dimethyl sulfoxide). The deltamethrin + hesperidin group received DM (0.5 mg/kg) + hesperidin (100 mg/kg) (both drugs dissolved in 1 mL dimethyl sulfoxide). All treatments were administered daily via the orogastric route for 14 days. At the end of the experiment, the rats were euthanized by cervical dislocation, and biochemical and histological analyses were performed.
Results: The biochemical tests showed significantly higher malondialdehyde (MDA) levels in the deltamethrin group than in the Sham group. Combined application of hesperidin and deltamethrin resulted in significantly lower MDA levels in the deltamethrin + hesperidin group than in the deltamethrin group. Histopathological examination of the periodontal tissues of the deltamethrin group revealed cell degeneration at the alveolar bone-tooth junction, including atypical cells, irregularity in collagen fibers, dilatation and congestion of the blood vessels, and inflammatory cell infiltrates distributed in aggregate and solitary forms. The deltamethrin + hesperidin group showed substantially less cell degeneration.
Conclusion: Hesperidin application helped alleviate deltamethrin toxicity by preventing oxidative stress and reducing cell degeneration.

How to cite this article:
İpek F, Deveci E, İpek P. Effect of hesperidin on deltamethrin toxicity in rat periodontal membrane. J Med Dent Invest 2023;4:e230332. https://doi.org/10.5577/jomdi.e230332

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Professionalization of Public Service Delivery in the Southern African Region
Authors: Mbandlwa Zamokuhle 
Published: October 2023

Background: Public service delivery in Africa has been hijacked by politicians who want to advance their political interests and deploy people, not based on how they can contribute to public service delivery. Most countries in Africa have been classified as corrupt states because of corrupt public officials.

Purpose: The purpose of this article is to show the importance of professionalizing public service delivery by ensuring that the public servants in Africa put the citizens first.

Objective: The objective of this article is to provide suggestions on how African governments can professionalize public service delivery. Public servants should not see their employment as means of their survival to earn a salary but as a calling to serve the people.

Research methodology: The study collected the existing data that is related to public service delivery in the countries of the Southern African region. Secondary data was collected to reach the findings and conclusions of this study.

Results: The study found that the existing gap in public service delivery in Africa is based on public servants themselves not owning up to their responsibilities, they need to offer the services to the public the same way they would expect the public services to be delivered to them.

Conclusion: The focus of this article is not on the processes and documentation required by public servants to be seen as professional individuals but the focus is on the existing gap.
Addressing Workplace Bullying: Protecting Human Rights in the Modern Workplace
Authors: Vijayakumar Gavya , Rajagopal Subashini 
Published: October 2023

Purpose: This paper aims to highlight how crucial it is to address workplace bullying as a violation of human rights and to provide ideas for both prevention and intervention. It seeks to draw attention to the negative consequences of workplace bullying on people and organizations while also providing advice on creating a secure and welcoming workplace that supports the rights and dignity of every employee.

Methodology: The research and literature on workplace bullying, human rights concepts, and successful preventative and intervention measures are all thoroughly reviewed in this study. The data was acquired from a variety of sources, including academic research, international human rights norms, legislative frameworks, and case studies from the actual world. This data is combined to give a comprehensive picture of workplace bullying, its effects, and effective ways to deal with it.

Results: According to the study, bullying at work hurts people's physical, emotional, and psychological health as well as an organization's production, morale, and reputation. The study discusses several kinds of workplace bullying, typical bullying conduct, and its effects on people and organizations. It also emphasizes the significance of workplace human rights norms, such as the right to dignity, a secure work environment, and freedom from harassment and discrimination.

Conclusion: As a breach of human rights, workplace bullying is a major problem that has to be addressed. By implementing thorough anti-bullying policies, fostering an inclusive culture, providing accessible reporting mechanisms, providing training and education, and ensuring efficient investigation and resolution procedures, organizations can prevent and address workplace bullying.
PENGARUH PERAN GANDA DAN BEBAN KERJA TERHADAP KINERJA KARYAWAN PT KHARISMA REKSA PRATAMA
Authors: Fabriansyah Nanda , Armaniah Henny 
Published: October 2023

PT Kharisma Reksa Pratama adalah perusahaan swasta yang bergerak dalam bidang Ekspedisi Impor & Ekspor dan merupakan salah satu Pengurus Jalur Kepalabandaran (PPJK) yang menggunakan sistem dan modul online, seperti PIB, PEB, CEISA 4.0, dan SLIM 3.0. Perusahaan ini telah berdiri sejak tahun 1992 dan berlokasi di Tanjung Priok, Jakarta Utara. Penelitian ini bertujuan untuk mengetahui pengaruh peran ganda dan beban kerja terhadap kinerja karyawan PT Kharisma Reksa Pratama. Terdapat 2 variabel bebas dalam penelitian ini yaitu peran ganda dan beban kerja, serta satu variabel terikat yaitu kinerja karyawan. Peneliti menggunakan metode kuantitatif dan sampel yang digunakan dalam penelitian ini berjumlah 44 responden. Teknik yang digunakan dalam penelitian ini adalah meltoldel sampling jelnuh. Data penelitian ini dianalisis dengan menggunakan olah data statistik SPSS 29.0 dengan hasilnya menunjukan bahwa variabel peran ganda tidak berpengaruh terhadap kinerja karyawan PT Kharisma Reksa Pratama, variabel beban kerja berpengaruh negatif signifikan terhadap kinerja karyawan PT Kharisma Reksa Pratama serta peran ganda dan beban kerja berpengaruh secara bersama-sama terhadap kinerja karyawan PT Kharisma Reksa Pratama.
APPLICATION OF DATA MINING IN HEALTHCARE OF BANGLADESH
Authors: Zawad Nafis Md 
Published: October 2023

The paper intends to discuss the status of data mining applications in the normal and critical healthcare system of Bangladesh. The paper also focuses on the data mining strategies and processes in the current healthcare system in Bangladesh. This is a secondary source-based review paper. The methodology chosen for the study is a literature review and document analysis. The literature review was done through the analysis of book chapters, research-based articles, review-based journal articles, organizational reports, and conference papers. The key findings of the study indicate that as Bangladesh is not a developed country and is a developing one, the country’s healthcare system is not up to the required standard, and the application of data mining techniques is very limited and in most cases, it is at the policy level. The implementation and practice of data-mining techniques is available in internationally recognized organizations and institutions. In these circumstances, the country’s healthcare policymakers and administrators should employ experts in data mining in healthcare services and facilities and standard technologies should be included in their administering the data mining in healthcare facilities. Besides, data mining should be incorporated with other related concepts and strategies to make the highest outcomes in health care systems.
Sistem Pakar Diagnosis Penyakit Tanaman Padi Dengan Metode Teorema Bayes
Authors: Kholifah Nurul 
Published: October 2023

One of the cultivated plants is rice, oryza sativa in Latin, although some varieties are wild rice. Rice cultivation began in Indonesia around 15000 BC, although it is thought to have originated in India or Indochina. Rice is the most important crop in agrarian countries like China, India, Bangladesh and Indonesia. The japonica and indica groups usually contain rice plants. According to archaeological evidence, japonica rice was first domesticated around 9,000 years ago in the Yangtze Valley in southern China. Meanwhile, around 5,000 years ago, indica rice was first grown in the Ganges River valley. Rice-producing grass plants fall into this category. For most Indonesians, rice is a staple food. At the time of growth, rice plants are susceptible to various diseases which cause farmers to fail to harvest. To find out the diseases that attack rice plants, an expert who can diagnose rice plant diseases is needed. An expert is someone who understands the problem of diagnosing a disease. However, the lack of agricultural officers/extensioners in the Seputih Banyak District area. The purpose of this research is to apply an expert system using the Bayes theorem method to overcome problems regarding rice plant diseases and the limitations of agricultural officers/extensioners. And can be accessed by farmers anywhere when they need an epert system to diagnose a disease that attack rice plants without having to need assistance from extension agricultural extension officers.
Closing the gap: Understanding and encouraging female entrepreneurship
Authors: Moore Elizabeth R 
Published: October 2023

Closing the gap: Understanding and encouraging female entrepreneurship
Dr Elizabeth R. Moore, Head of Leadership at The University of Law Business School, provides a comprehensive analysis on bridging the gender gap to welcome more female entrepreneurship. Over the past two decades, women globally have begun to edge slightly closer to men in filling managerial and C-suite positions in many industries. There is one sector, however, that has failed to gain the advances made across other industries – this is the area of entrepreneurship. In the UK, the numbers have improved slightly. According to The Rose Review, ‘In 2022, women in the UK established over 150,000 new companies – more than twice as many as in 2018. Our findings show that 16 to 25-year-old women founded nearly 17,500 businesses in 2022, a figure that’s more than 22 times greater than in 2018. All-female-led companies represented 20% of all businesses in the UK in 2022, up from 16% in 2018.’ (The Alison Rose Review of Female Entrepreneurship, February, 2023).
Hydrogen therapy: An emerging therapeutic strategy in cancer treatment?
Authors: Brandi Giovanni , Tavolari Simona 
Published: October 2023

Hydrogen therapy: An emerging therapeutic strategy in cancer treatment?
Professor Giovanni Brandi (1,2) and Dr Simona Tavolari (1,2) from the University of Bologna discuss findings from preclinical and clinical studies that highlight the potential of hydrogen therapy in cancer treatment. Hydrogen is the lightest chemical element and is present in the atmosphere at non-toxic concentrations (less than one part per million) as a colourless and odourless gas. In humans, it is produced from carbohydrates not absorbed in the intestine through the anaerobic metabolism of some intestinal bacteria containing the enzyme hydrogenase. Then, it is partially diffused into the bloodstream and released from the lungs during exhalation. Considered for a long time a physiologically inert gas, recent studies have demonstrated that hydrogen possesses significant antioxidant and anti-inflammatory properties that make the use of this molecule potentially applicable in many different clinical settings, including cancer treatment.
Online pressure and gas analysis of lithium-ion cells during abuse tests
Authors: Ziebert Carlos 
Published: October 2023

Online pressure and gas analysis of lithium-ion cells during abuse tests
Dr Carlos Ziebert, Leader of the Group Batteries – Calorimetry and Safety, KIT, explains how online venting gas analysis of batteries can be performed using a combination of battery calorimetry and online mass spectrometry. The main objective of the AnaLiBa project (Analytics of LithiumIon- Batteries) is the joint method development of a standardised sample handling process for the gas analysis of large cells by combining an accelerating rate calorimeter (ARC) and online mass spectrometry (MS). It is a part of the competence cluster Analytics/Quality Assurance (AQua) funded by the German Federal Ministry of Education and Research (BMBF). The Fraunhofer Institute for Chemical Technology coordinates the project.
CB₂R ligands to treat inflammatory diabetes
Authors: Grether Uwe , Nazaré Marc 
Published: October 2023

CB₂R ligands to treat inflammatory diabetes
Researchers discuss how scientific innovations might influence the discovery of future tailor-made CB2R-based anti-inflammatory treatments. The G-protein-coupled receptor (GPCR) type-2 cannabinoid receptor (CB2R) is a 2 highly promising pharmacological target for novel anti-inflammatory medicines. (1) CB2R is an essential component of a vital lipid signaling system that tremendously influences multiple human health and disease states ranging from metabolic disorders to neurodegenerative diseases and is termed endocannabinoid system (ECS). Few CB2R-activation-based drugs have been launched. (2) Several candidates are under active clinical development, aiming at treating diseases in which inflammatory processes play a significant role or are the underlying reason. Recent scientific innovations in ECS research and drug discovery in general (Figure 1) are now being incorporated into the design, synthesis and evaluation of novel ligands targeting CB2R. They will impact the generation of further improved tailor-made medicines for inflammatory diseases.
Major depressive disorder: Brain signals as biomarkers for depression
Authors: Costa Tiago 
Published: October 2023

Major depressive disorder: Brain signals as biomarkers for depression
Tiago Costa from Delft University of Technology explores the potential of neuroimaging techniques, specifically non-invasive electroencephalography (EEG), in detecting biomarkers for depression. Major Depressive Disorder (MDD) is a prevalent and complex mental disorder posing significant challenges to both individuals and societies worldwide. An early and accurate diagnosis of depression is essential for effective treatment and management. In recent years, advancements in neuroimaging techniques have opened new avenues for identifying biomarkers that could aid in the diagnosis and understanding of depression. Among these techniques, non-invasive electroencephalography (EEG) has gained attention in the last decade for its potential to detect depression biomarkers. While there is significant heterogeneity in terms of methodologies, sample sizes, and research objectives, several consistent patterns and findings emerge.
FFEA software: Repeated early innovation
Authors: Leng Joanna 
Published: October 2023

FFEA software: Repeated early innovation
Dr Joanna Leng, Senior Research Software Engineering Fellow at the University of Leeds, discusses software with repeated early innovation using the example of the FFEA software. This article analyses the application of software engineering (SE) tools and practices and research software engineering (RSE) practices to the Fluctuating Finite Element Analysis (FFEA) software, a mesoscale modelling package. In 2016, I met the FFEA team to discuss improving their software. In 2020, I started working with them to develop a roadmap for the FFEA software by assessing their research interests and software.
Climate, heatwaves, nearshore ecosystems and the sunflower sea star
Authors: Traiger Sarah , Suryan Robert M , Coletti Heather A , Esler Daniel 
Published: October 2023

Climate, heatwaves, nearshore ecosystems and the sunflower sea star
Sarah Traiger, Biologist at the U.S. Geological Survey, in this wide-ranging analysis, examines climate, heatwaves, nearshore ecosystems, and the plight of the sunflower sea star. The sunflower sea star is a wide-ranging and important species in the nearshore ecosystem. At the nexus of the ocean and the land lies the nearshore ecosystem, which includes the intertidal, an area exposed during low tides and submerged during high tides. Intertidal species in the intertidal are adapted to extreme environmental variability of temperatures, waves, and salinity. Species’ tolerance to desiccation determines the elevation within the intertidal they occupy.
Data management plans as a tool for making data fair
Authors: Götz Andy 
Published: October 2023

Data management plans as a tool for making data fair
Andy Götz (ESRF Data Manager and PaNOSC Coordinator), explores if and how Data Management Plans (DMPs) are essential for making data FAIR. In the previous articles in this series on FAIR data, we explained how the scientific world is undergoing a major change with the widespread adoption of the so-called FAIR principles for research data. FAIR stands for Findable, Accessible, Interoperable and Reusable and was first published in a paper in Nature during 2016. (1) The FAIR principles were proposed to ensure research data are made available to the scientific community so that they can be found, downloaded, understood and reused. The goal is to make data used in scientific publications available to the community so they can verify the results, reproduce them and eventually derive new results from them. Applying the FAIR principles systematically to research data will address the reproducibility, also known as the replicability crisis (2) in science. It will make scientific data available for verifying results and use beyond their original purpose.
Knee health promotion and cell therapy for knee osteoarthritis
Authors: Lyu Shaw-Ruey 
Published: October 2023

Knee health promotion and cell therapy for knee osteoarthritis
Shaw-Ruey Lyu, Professor from Dalin Tzu-Chi Hospital, Tzu-Chi University, says that the knee health promotion option and cell therapy are a perfect combination for knee osteoarthritis. Knee osteoarthritis (knee OA) is commonly but mistakenly referred to as a degenerative process of the knee. The mainstream medical community has devoted uncounted resources and talents to identifying the cause of knee OA, but that effort has only produced controversial results. Consequently, sufferers of knee OA have not been able to rest, and the deteriorating course of knee OA symptoms, which typically start from stage I and worsen to stages II, III, IV, and V, puts the patients through increasingly agonising pain and discomfort. The mainstream medical community collectively has tried to offer relief to their knee OA patients, such as nonpharmacological interventions, systemic drug treatment, intra-articular therapies ranging from corticosteroids to hyaluronans to more recently platelet-rich plasma, and more invasive surgical procedures such as arthroscopy or corrective osteotomy.
The mechanisms and benefits of exercise
Authors: Wessells Robert 
Published: October 2023

The mechanisms and benefits of exercise
At Wayne State University, Robert Wessells and his team are making significant strides in identifying potential exercise mediators or mimetics that could help mitigate pathologies resulting from prolonged sedentary periods. Exercise is an indispensable part of our daily life to maintain a healthy body and brain across ages. Regular exercise has been shown to reduce the incidence of many age-related diseases and preserves healthy function during normal aging, improving quality of life and independence. However, chronic exercise remains inaccessible to portions of the population due to injury, illness, advanced age or job-enforced sedentary periods. Therefore, identifying potential exercise mediators or mimetics that can deliver the benefits of exercise to sedentary people would be potentially transformative in reducing disease burden worldwide. At Wayne State University in Detroit, Michigan, USA, Dr Robert (RJ) Wessells and his lab team have used the many genetic tools available for use in fruit flies to identify several single molecules that act as powerful exercise mimetics in the brain and muscle of sedentary flies.
Harnessing redox power for biotechnological application in purple non-sulphur bacteria
Authors: Bose Arpita , Morrison Hailee 
Published: October 2023

Harnessing redox power for biotechnological application in purple non-sulphur bacteria
Here we explore purple non-sulfur bacteria (PNSB) and some of its biotech applications, with a focus on how these applications have been enhanced by manipulating the flow of reducing power. Cellular metabolism refers to the sum of chemical reactions that cells use to obtain energy and material to live, grow, and make products. Many of these reactions are performed by specialized proteins called enzymes, which act on a specific substrate, or input, to produce a specific effect or product, also called a metabolite. To make metabolites, you need three major inputs: carbon, energy, and electrons. Depending on the organism, carbon can be fixed from atmospheric CO2, or can be obtained from organic compounds like carbohydrates or lipids. Energy can be generated in a variety of ways, but typically results in the formation of phosphate bonds in molecules like adenosine triphosphate (ATP) for widespread use in the cell.
Ultravision joins the fight against peritoneal cancer
Authors: Griffiths Dominic 
Published: October 2023

Ultravision join the fight against peritoneal cancer
Peritoneal metastases (PM) refers to cancer that has spread from primary cancer in other organs in the abdomen to the peritoneum, the membrane that lines the abdominal cavity. According to the WHO, there are over seven million new primary abdominal cancer cases each year (1), and depending upon the primary cancer, up to 60% of these will present evidence of PM. (2) As a result, it is estimated that every 30 seconds, a patient is diagnosed with peritoneal metastases. In most cases, at diagnosis, it is typically an advanced, incurable disease. Current therapy guidelines recommend palliative systemic chemotherapy. However, with poor blood supply to the peritoneum, efficacy is poor, and side effects are debilitating. As a result, this terrible disease has a poor prognosis, with patient survival worse than lung and liver metastases. (3) It remains a high, unmet medical need.
Computational biology is poised to advance precision medicine with machine learning
Authors: Mertins Susan D 
Published: October 2023

Computational biology is poised to advance precision medicine with machine learning
Today, scientists are attempting to model whole cells using computational biology, building virtual cells that capture the dynamics of living. In the post-genomic era, vast quantities of data describing the parts of living cells, both normally functioning and diseased, have been amassed. Understanding how cells behave has been the goal of reductionist science, and many of the principles are well understood. In elucidating the details, complexity has been revealed to the degree that scientists have limited capacity to understand the systems underlying the biological networks. This is to say, cellular behavior is difficult to predict.