bluuebunny/crossref_metadata_2025_split huggingface dataset:
Derivational morphology in Modern Greek
Authors: Koutsoukos Nikos , Efthymiou Angeliki 
Published: November 2023

Abstract
Derivational morphology is an umbrella term used for concatenative and non-concatenative processes for the formation of new lexemes. In Modern Greek, derivational morphology is one of the major morphological processes along with compounding and inflection. In recent years, research on derivational morphology has evolved rapidly. We present here the state-of-the-art on the recent advances in the derivational morphology of Modern Greek. First, we present affixational derivation by focusing on the main features of the derivational affixes used in Modern Greek and then we present the non-concatenative derivational processes. We also discuss the main theoretical issues related to derivational morphology, that is, constraints, competition and productivity of derivational patterns, and the main theoretical approaches to Modern Greek derivational structures. Finally, we present some general themes of derivational morphology, including the relationship between derivation and other morphological processes and the role of derivational morphology in scientific terminology, language teaching/lexicography and psycholinguistics. We aim to contribute to better understanding of how morphology works by highlighting the potential of research on derivational morphology in Modern Greek.
The Role of Soft Law of the Council of Europe in Polish Court Proceedings: A Historical Overview
Authors: Grzelak-Bach Katarzyna 
Published: November 2023

Abstract
This paper presents a historical overview of the role of soft law of the Council of Europe in Polish court proceedings. Soft law refers to legal acts that are not formally legally binding, but nevertheless constitute important guidelines for the operation of state authorities. The article focuses on the role of documents adopted by the Council of Europe, such as resolutions, recommendations or declarations, in the process of shaping the Polish legal system. An analysis of the guidelines and standards introduced by the Council of Europe in the field of human rights protection, equality and standards of court proceedings has been undertaken. The paper also shows the evolution of the position of Polish courts in relation to the soft law of the Council of Europe. Have the documents adopted by the Council of Europe been incorporated into legal arguments and jurisprudence in the Polish legal system and how? The study aims to outline the historical key moments and trends in the application of soft law of the Council of Europe in Polish court proceedings. It shows the impact of these soft instruments on the development of the Polish legal system and legal culture, as well as on the evolution of the perception and use of international standards by Polish courts.
The first record of Mammeoxylon lanneoides Lemoigne (Clusiaceae) from Egypt, with a summary of the Egyptian Oligocene wood flora
Authors: Ziada Nermeen A. 
Published: November 2023

Summary
A petrified wood resembling the modern wood of Mammea africana Sabine is described from the Oligocene Gebel Ahmer Formation from Egypt. The fossil wood is attributed to Mammeoxylon lanneoides Lemoigne according to the xylotomical homologies with the species recorded previously from Ethiopia. The wood anatomy observed in the fossil specimen, along with the climatic information available from the Nearest Living Relative comparison, suggests a tropical humid climate at the site of growth. This is the oldest record of Mammeoxylon Lemoigne in Africa, which contributes towards the understanding of the origin and paleo-dispersal pathways of the genus. A list of 46 Egyptian Oligocene wood species attributed to 11 families is also given.
Marāgha Ceased to Function: The Ṭūsī Family’s Intellectual Network and Īl-Khānid Political Itinerance
Authors: Isahaya Yoichi 
Published: November 2023

Abstract
While there is no consensus as to when the Marāgha observatory, centre of a Eurasian-scale intellectual network, ceased to function, given that no historical sources mention such a date, by focusing more on the Īl-Khānid political context than on the scientific activities at the observatory that have so far attracted scholarly attention, I argue that the termination of the observatory’s activity overlapped with the downfall of Aṣīl al-Dīn b. Naṣīr al-Dīn (d. ca. 1317) in 1309/10. Naṣīr al-Dīn al-Ṭūsī (1201–1274) acquired the office of trustee of the waqf endowments for the observatory. This office was inherited after his death by his sons. However, the family property related to the religious endowments was targeted, which resulted in the family’s fall. Thereafter, the eighth īl-khān, Öljeitü (r.1304–1316), did not station his mobile court in Marāgha, which marked a shift of the intellectual centre of the Īl-Khānid dynasty away from the observatory.
Setting sustainability agenda at the local level: a process of compromise making
Authors: Arda Lama (Al) , Pichault Francois , Esposito Giovanni , Crutzen Nathalie 
Published: November 2023

This paper examines how local actors set the sustainability agenda. By relying on the economies of worth, we explain how actors dwell upon multiple worlds to evaluate what is valuable, what is not valuable, and to promote their views. Empirically, we draw evidence from the Walloon region in Belgium, by investigating how multiple actors discuss their views in an attempt to set a sustainability agenda. We outline the multiple worlds that actors refer to during their interaction, the moments of critiques and how a compromise is shaped where the green world is given a significant prominence. Furthermore, we identify a set of mechanisms that facilitated the multi-actor interaction to shape a collective compromise as a continuous process. Points for practitioners (1) Local governments play a crucial role in sustainability policies due to their proximity to local communities, enabling the development of tailored solutions, and direct engagement with citizens to address local environmental and social challenges. (2) Agenda-setting in local sustainability policies is intricate and frequently contentious due to the diverse values, interests, and preferences of all involved stakeholders. (3) Drawing on Boltanski and Thévenot's orders of worth theory, this paper offers researchers and practitioners an approach to unpack and understand the varied values, interests, and preferences of all involved stakeholders. (4) This paper identifies and elucidates three mechanisms (reflection, engagement, and alteration) that facilitate interactions among stakeholders, allowing them to reach a compromise on a shared sustainability agenda.
Determination of age-specific reference intervals for selected serum and urinary biomarkers in elderly cats
Authors: Mortier Femke , van Leeuwenberg Robby , Daminet Sylvie , Paepe Dominique 
Published: November 2023

Objectives Annual health screening is recommended in elderly cats to allow the early detection of conditions such as chronic kidney disease (CKD) and hyperthyroidism. Nevertheless, age-specific reference intervals (RIs) for renal and thyroid parameters in this population are lacking. The aim of this study was to determine age-specific RIs for selected serum and urine biomarkers related to CKD and hyperthyroidism, namely serum creatinine (sCr), symmetric dimethylarginine (SDMA), phosphate (P), total calcium (tCa), total thyroxine (TT4), urinary protein:creatinine ratio (UPC) and urine specific gravity (USG). These RIs were established for elderly cats (aged ⩾7 years) in general, as well as for mature adult cats (aged 7–10 years) and senior cats (aged >10 years) separately. Methods A prospective study was conducted on client-owned cats aged ⩾7 years and considered healthy by their owners. The cats were screened to rule out metabolic and systemic diseases by means of a thorough history, complete physical examination, blood examination and urinalysis. The data from 206 healthy elderly cats (134 mature adult and 72 senior cats) were included. Age-appropriate RIs were determined following the guidelines of the American Society of Veterinary Clinical Pathology and compared with existing laboratory RIs. Results Clinically relevant differences between the age-specific RI and the laboratory RI were found for several variables. Compared with the laboratory RI, the upper limit of the RI for cats aged ⩾7 years was lower for sCr, TT4 and P, and higher for SDMA. The lower limit of the age-appropriate RI was lower for USG. The new RI was almost identical to the existing laboratory RI for tCa and UPC. Conclusions and relevance Using age-specific RIs for renal and thyroid biomarkers in mature adult and senior cats has important clinical consequences for the interpretation of health screening results in elderly cats. This confirms the need to adapt laboratory RIs to the specific animal population for which the RI will be used.
Moderate-Severe TBI as a Progressive Disorder: Patterns and Predictors of Cognitive Declines in the Chronic Stages of Injury
Authors: Green Robin E. A. , Dabek Marika K. , Changoor Alana , Rybkina Julia , Monette Georges A. , Colella Brenda 
Published: November 2023

Background Moderate-severe traumatic brain injury (TBI) has been associated with progressive cognitive decline in the chronic injury stages in a small number of studies. Objective This study aimed to (i) replicate our previous findings of decline from 1 to 3+ years post-injury in a larger, non-overlapping sample and (ii) extend these findings by examining the proportion of decliners in 2 earlier time windows, and by investigating novel predictors of decline. Methods N = 48 patients with moderate-severe TBI underwent neuropsychological assessment at 2, 5, 12 months, and 30+ months post-injury. We employed the Reliable Change Index (RCI) to evaluate decline, stability and improvement across time and logistic regression to identify predictors of decline (demographic/cognitive reserve; injury-related). Results The proportions of patients showing decline were: 12.5% (2-5 months post-injury), 17% (5-12 months post-injury), and 27% (12-30+ months post-injury). Measures of verbal retrieval were most sensitive to decline. Of the predictors, only left progressive hippocampal volume loss from 5 to 12 months post-injury significantly predicted cognitive decline from 12 to 30+ months post-injury. Conclusions Identical to our previous study, 27% of patients declined from 12 to 30+ months post-injury. Additionally, we found that the further from injury, the greater the proportion of patients declining. Importantly, earlier progressive hippocampal volume loss predicted later cognitive decline. Taken together, the findings highlight the need for ongoing research and treatment that target these deleterious mechanisms affecting patients in the chronic stages of moderate-severe TBI.
Factors for progressive pulmonary fibrosis in connective tissue disease-related interstitial lung disease
Authors: Kim Kyuhwan , Lee Jongmin , Jo Yong Suk 
Published: November 2023

Background: Progressive fibrosis can occur in connective tissue disease (CTD)-related interstitial lung disease (ILD) and make the prognosis worse. Objectives: This study aimed to investigate factors related to progressive pulmonary fibrosis (PPF) phenotype in CTD-ILDs. Design: Medical records of patients diagnosed as CTD and ILD at a single, tertiary hospital in South Korea were retrospectively reviewed. Methods: Patients whose lung functions were followed up for more than a year were included in analysis. PPF was defined as forced vital capacity (FVC) declined ⩾10% or diffusion capacity of carbon monoxide (DLco) ⩾15%. Results: Of 110 patients with CTD-ILD, 24.5% progressed into PPF. Rheumatoid arthritis (RA) and Sjogren’s disease accounted for more than 63% of PPF. Compositions of CTD type were similar between PPF and non-PPF. Clinical characteristics and proportion of usual interstitial pneumonia (UIP) pattern on chest images were also similar between PPF and non-PPF. Approximately 10% of patients in both groups were treated with anti-fibrotic agents. Use of systemic steroids and/or other immunomodulating agents lowered the risk of developing PPF in CTD-ILD patients after adjusting for gender-age-physiology score and smoking status (adjusted odds ratio: 0.25, 95% confidence interval: 0.07–0.85). Conclusion: About a quarter of CTD-ILD progressed into PPF. The use of immunomodulating agents lowered the risk of developing PPF. To improve outcomes of patients, future studies need to detect patients at higher risk for PPF earlier and set up clinical guidelines for treatment strategies in the process of PPF.
Integrin α10β1-Selected Mesenchymal Stem Cells Reduce Pain and Cartilage Degradation and Increase Immunomodulation in an Equine Osteoarthritis Model
Authors: Andersen Camilla , Jacobsen Stine , Uvebrant Kristina , Griffin John F. , Vonk Lucienne Angela , Walters Marie , Berg Lise Charlotte , Lundgren-Åkerlund Evy , Lindegaard Casper 
Published: November 2023

ObjectiveIntegrin α10β1-selected mesenchymal stem cells (integrin α10-MSCs) have previously shown potential in treating cartilage damage and osteoarthritis (OA) in vitro and in animal models in vivo. The aim of this study was to further investigate disease-modifying effects of integrin α10-MSCs.DesignOA was surgically induced in 17 horses. Eighteen days after surgery, horses received 2 × 107integrin α10-MSCs intra-articularly or were left untreated. Lameness and response to carpal flexion was assessed weekly along with synovial fluid (SF) analysis. On day 52 after treatment, horses were euthanized, and carpi were evaluated by computed tomography (CT), MRI, histology, and for macroscopic pathology and integrin α10-MSCs were traced in the joint tissues.ResultsLameness and response to carpal flexion significantly improved over time following integrin α10-MSC treatment. Treated horses had milder macroscopic cartilage pathology and lower cartilage histology scores than the untreated group. Prostaglandin E2 and interleukin-10 increased in the SF after integrin α10-MSC injection. Integrin α10-MSCs were found in SF from treated horses up to day 17 after treatment, and in the articular cartilage and subchondral bone from 5 of 8 treated horses after euthanasia at 52 days after treatment. The integrin α10-MSC injection did not cause joint flare.ConclusionThis study demonstrates that intra-articular (IA) injection of integrin α10-MSCs appears to be safe, alleviate pathological changes in the joint, and improve joint function in an equine post-traumatic osteoarthritis (PTOA) model. The results suggest that integrin α10-MSCs hold promise as a disease-modifying osteoarthritis drug (DMOAD).
Investigating self-report and neuropsychological assessments of cognitive flexibility in people with and without persistent pain: An online, cross-sectional, observational study
Authors: Howlett Caitlin A , Stanford Tyman , Berryman Carolyn , Karran Emma L , Bellan Valeria , Coussens Scott , Miles Stephanie , Moseley G Lorimer 
Published: November 2023

Introduction People with persistent pain experience problems modifying their cognition and behaviours when task or environmental demands change – abilities otherwise known as cognitive flexibility. However, limitations and inconsistent results of previous studies raise concerns over the quality of that evidence. We aimed to determine whether people with and without persistent pain differ on two assessments that are commonly used to assess cognitive flexibility. We also examined the relationship between the two assessments and explored whether people with and without persistent pain are distinguishable based on their scores on these assessments. Methods Participant demographics and symptoms of anxiety and depression were assessed. Participants completed the Cognitive Flexibility Inventory (CFI) and the Wisconsin Card Sorting Test (WCST). Multiple linear regression on the two outcome variables: CFI (total score) and WCST (% perseverative responses) was applied using backward stepwise selection. Both outcomes were calculated as a standardised proportion of the outcome scale and log-odds transformed to meet the model assumptions. Correlation analysis and logistic regression were used to investigate our secondary and exploratory aims. Results Data were available from 128 participants with persistent pain and 68 pain-free controls. After adjusting for covariates, no differences were found between people with and without persistent pain on either assessment of cognitive flexibility. No significant correlations were detected between the two assessments in either group. The probability of having persistent pain was also not associated with scores on either or both assessments. Conclusion ‘Cognitive flexibility’ appears similar in people with and without persistent pain.
Platelets mediate the clearance of senescent red blood cells by forming prophagocytic platelet-cell complexes
Authors: Ningtyas Dian C. , Leitner Florentina , Sohail Huma , Thong Yee Lin , Hicks Sarah M. , Ali Sidra , Drew Megan , Javed Kiran , Lee Jiwon , Kenangalem Enny , Poespoprodjo Jeanne R. , Anstey Nicholas M. , Rug Melanie , Choi Philip Y.-I. , Kho Steven , Gardiner Elizabeth E. , McMorran Brendan J. 
Published: November 2023

Abstract
In humans, ∼0.1% to 0.3% of circulating red blood cells (RBCs) are present as platelet-RBC (P-RBC) complexes, and it is 1% to 2% in mice. Excessive P-RBC complexes are found in diseases that compromise RBC health (eg, sickle cell disease and malaria) and contribute to pathogenesis. However, the physiological role of P-RBC complexes in healthy blood is unknown. As a result of damage accumulated over their lifetime, RBCs nearing senescence exhibit physiological and molecular changes akin to those in platelet-binding RBCs in sickle cell disease and malaria. Therefore, we hypothesized that RBCs nearing senescence are targets for platelet binding and P-RBC formation. Confirming this hypothesis, pulse-chase labeling studies in mice revealed an approximately tenfold increase in P-RBC complexes in the most chronologically aged RBC population compared with younger cells. When reintroduced into mice, these complexes were selectively cleared from the bloodstream (in preference to platelet-free RBC) through the reticuloendothelial system and erythrophagocytes in the spleen. As a corollary, patients without a spleen had higher levels of complexes in their bloodstream. When the platelet supply was artificially reduced in mice, fewer RBC complexes were formed, fewer erythrophagocytes were generated, and more senescent RBCs remained in circulation. Similar imbalances in complex levels and senescent RBC burden were observed in humans with immune thrombocytopenia (ITP). These findings indicate that platelets are important for binding and clearing senescent RBCs, and disruptions in platelet count or complex formation and clearance may negatively affect RBC homeostasis and may contribute to the known risk of thrombosis in ITP and after splenectomy.
Survival in primary hemophagocytic lymphohistiocytosis, 2016 to 2021: etoposide is better than its reputation
Authors: Böhm Svea , Wustrau Katharina , Pachlopnik Schmid Jana , Prader Seraina , Ahlmann Martina , Yacobovich Joanne , Beier Rita , Speckmann Carsten , Behnisch Wolfgang , Ifversen Marianne , Jordan Michael , Marsh Rebecca , Naumann-Bartsch Nora , Mauz-Körholz Christine , Hönig Manfred , Schulz Ansgar , Malinowska Iwona , Hines Melissa , Nichols Kim E. , Gil-Herrera Juana , Talano Julie-An , Crooks Bruce , Formankova Renata , Jorch Norbert , Bakhtiar Shahrzad , Kühnle Ingrid , Streiter Monika , Nathrath Michaela , Russo Alexandra , Dürken Matthias , Lang Peter , Lindemans Caroline , Henter Jan-Inge , Lehmberg Kai , Ehl Stephan 
Published: November 2023

Abstract
Primary hemophagocytic lymphohistiocytosis (pHLH) is a life-threatening hyperinflammatory syndrome that develops mainly in patients with genetic disorders of lymphocyte cytotoxicity and X-linked lymphoproliferative syndromes. Previous studies with etoposide-based treatment followed by hematopoetic stem cell transplantation (HSCT) resulted in 5-year survival of 50% to 59%. Contemporary data are lacking. We evaluated 88 patients with pHLH documented in the international HLH registry from 2016-2021. In 12 of 88 patients, diagnosis was made without HLH activity, based on siblings or albinism. Major HLH-directed drugs (etoposide, antithymocyte globulin, alemtuzumab, emapalumab, ruxolitinib) were administered to 66 of 76 patients who were symptomatic (86% first-line etoposide); 16 of 57 patients treated with etoposide and 3 of 9 with other first-line treatment received salvage therapy. HSCT was performed in 75 patients; 7 patients died before HSCT. Three-year probability of survival (pSU) was 82% (confidence interval [CI], 72%-88%) for the entire cohort and 77% (CI, 64%-86%) for patients receiving first-line etoposide. Compared with the HLH-2004 study, both pre-HSCT and post-HSCT survival of patients receiving first-line etoposide improved, 83% to 91% and 70% to 88%. Differences to HLH-2004 included preferential use of reduced-toxicity conditioning and reduced time from diagnosis to HSCT (from 148 to 88 days). Three-year pSU was lower with haploidentical (4 of 9 patients [44%]) than with other donors (62 of 66 [94%]; P &lt; .001). Importantly, early HSCT for patients who were asymptomatic resulted in 100% survival, emphasizing the potential benefit of newborn screening. This contemporary standard-of-care study of patients with pHLH reveals that first-line etoposide-based therapy is better than previously reported, providing a benchmark for novel treatment regimes.
Laparoscopic versus open partial nephrectomy: prospective randomized study for assessment of surgical, functional, and oncological outcomes
Authors: Elmohamady Basheer N. , Goma Rabea , Gharib Tarek , Mostafa Mohamed K. , Nouh Islam 
Published: November 2023

Abstract
Background
The purpose of this study was to compare the surgical, functional, and oncological outcomes between open partial nephrectomy (OPN) and laparoscopic partial nephrectomy (LPN).

Methods
This prospective, randomized study was performed on patients who underwent partial nephrectomy under general anesthesia. Patients were randomized using the closed envelope method to either LPN or OPN. Baseline demographics and surgical, functional, and oncological outcomes were compared. A per-protocol analysis was used.

Results
Randomized study was conducted on 166 patients. The LPN, in comparison to the OPN group, was associated with significantly shorter hospital stay (3 vs. 4 days), less blood transfusion (10% vs. 12%), longer operative time (134 min vs. 124 min), lower visual analog pain score (7 vs. 8), and lower estimated GFR (70.7 ± 17.5 vs. 72.3 ± 14.7).

Conclusions
Oncological and functional results were comparable between LPN and OPN. However, LPN was superior to open surgery because of less hospital stay, visual analog pain score, and blood loss.
Speed control with low complexity for multiple autonomous vehicles in roundabouts
Authors: Farkas Zsófia , Németh Balázs , Mihály András , Gáspár Péter 
Published: November 2023

AbstractThe paper introduces a high level speed control method for the coordination of multiple autonomous vehicles (AVs) in roundabout scenarios. The aim of the control method is to guarantee collision-free motion of the AVs, and similarly, to minimize their traveling time. In the method a priority-based ordering process of the AVs is used, which enforces the time-efficient motion of the AVs. The collision-free motion is guaranteed through an optimization-based method including control input constraints. The ordering process and the optimization form a low complexity solution, which requires low computation effort. The proposed control strategy is involved in the high level of a hierarchical control structure. The effectiveness of the proposed control strategy is illustrated by simulation examples and Hardware-in-the-Loop demonstration.