bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-Reported Outcomes (PROs) and PRO Remission Rates in 12,262 Biologic-Naïve Patients With Psoriatic Arthritis Treated With Tumor Necrosis Factor Inhibitors in Routine Care
Authors: Ørnbjerg Lykke M. , Rugbjerg Kathrine , Georgiadis Stylianos , Rasmussen Simon H. , Jacobsson Lennart , Loft Anne G. , Iannone Florenzo , Fagerli Karen M. , Vencovsky Jiri , Santos Maria J. , Möller Burkhard , Pombo-Suarez Manuel , Rotar Ziga , Gudbjornsson Bjorn , Cefle Ayse , Eklund Kari , Codreanu Catalin , Jones Gareth , van der Sande Marleen , Wallman Johan K. , Sebastiani Marco , Michelsen Brigitte , Závada Jakub , Nissen Michael J. , Sanchez-Piedra Carlos , Tomšič Matija , Love Thorvardur J. , Relas Heikki , Mogosan Corina , Hetland Merete L. , Østergaard Mikkel 
Published: January 2024

ObjectiveTo evaluate patient-reported outcomes (PROs) after initiation of tumor necrosis factor inhibitor (TNFi) treatment in European real-world patients with psoriatic arthritis (PsA). Further, to investigate PRO remission rates across treatment courses, registries, disease duration, sex, and age at disease onset.MethodsVisual analog scale or numerical rating scale scores for pain, fatigue, patient global assessment (PtGA), and the Health Assessment Questionnaire–Disability Index (HAQ-DI) from 12,262 patients with PsA initiating a TNFi in 13 registries were pooled. PRO remission rates (pain ≤ 1, fatigue ≤ 2, PtGA ≤ 2, and HAQ-DI ≤ 0.5) were calculated for patients still on the treatment.ResultsFor the first TNFi, median pain score was reduced by approximately 50%, from 6 to 3, 3, and 2; as were fatigue scores, from 6 to 4, 4, and 3; PtGA scores, from 6 to 3, 3, and 2; and HAQ-DI scores, from 0.9 to 0.5, 0.5, and 0.4 at baseline, 6, 12, and 24 months, respectively. Six-month Lund Efficacy Index (LUNDEX)–adjusted remission rates for pain, fatigue, PtGA, and HAQ-DI scores were 24%, 31%, 36%, and 43% (first TNFi); 14%, 19%, 23%, and 29% (second TNFi); and 9%, 14%, 17%, and 20% (third TNFi), respectively. For biologic-naïve patients with disease duration < 5 years, 6-month LUNDEX-adjusted remission rates for pain, fatigue, PtGA, and HAQ-DI scores were 22%, 28%, 33%, and 42%, respectively. Corresponding rates for patients with disease duration > 10 years were 27%, 32%, 41%, and 43%, respectively. Remission rates were 33%, 40%, 45%, and 56% for men and 17%, 23%, 24%, and 32% for women, respectively. For patients aged < 45 years at diagnosis, 6-month LUNDEX-adjusted remission rate for pain was 29% vs 18% for patients ≥ 45 years.ConclusionIn 12,262 biologic-naïve patients with PsA, 6 months of treatment with a TNFi reduced pain by approximately 50%. Marked differences in PRO remission rates across treatment courses, registries, disease duration, sex, and age at onset of disease were observed, emphasizing the potential influence of factors other than disease activity on PROs.
Systemic Sclerosis in Individuals With Exposure to World Trade Center Ground Zero Rescue and Recovery Efforts: A Case Series
Authors: Own Maryam , Bloostein Aliza , Spiera Robert , Berman Jessica R. , Moline Jacqueline , Gordon Jessica K. , Lakin Kimberly S. 
Published: January 2024

ObjectiveThe World Trade Center (WTC) attack in New York resulted in a dust plume containing silica, hydrocarbons, and asbestos. Autoimmune disorders have been reported among those with WTC site exposure. The characteristics of individuals developing systemic sclerosis (SSc) have not been previously described. The purpose of this study was to describe the features of patients with SSc with WTC exposure.MethodsData were collected from 11 patients with SSc or SSc spectrum conditions who reported exposure to the WTC site. Seven patients completed an exposure assessment.ResultsOf the 11 patients, the majority (n = 8) were female. The median (range) for age at diagnosis was 46 (36-75) years, time between exposure and first non-Raynaud phenomenon SSc symptom was 8 (1-19) years, and time between exposure and diagnosis was 11 (2-18) years. Fifty-five percent had SSc onset > 5 years from WTC exposure. Five patients had limited cutaneous SSc, 3 patients had diffuse cutaneous SSc, 1 patient with SSc features met criteria for mixed connective tissue disease (CTD), and 2 patients had undifferentiated CTD with features of SSc. Four patients had overlapping features with other CTDs. Interstitial lung disease (ILD) was present in 10 patients. Five of 11 patients had a history of tobacco use. Seven of 7 patients who completed the questionnaire reported other hazardous exposures outside of WTC. Of these, only 2 patients reported personal protective equipment use.ConclusionA high frequency of ILD and overlap features were observed among patients with SSc with WTC exposure. Future studies are needed to characterize this association.
Bowel preparation protocol for hospitalized patients ages 50 years or older: A randomized controlled trial
Authors: He Yu , Liu Qi , Chen Yi-Wen , Cui Li-Jian , Cao Kai , Guo Zi-Hao 
Published: January 2024

BACKGROUND
The incidence and mortality rate of colorectal cancer progressively increase with age and become particularly prominent after the age of 50 years. Therefore, the population that is ≥ 50 years in age requires long-term and regular colonoscopies. Uncomfortable bowel preparation is the main reason preventing patients from undergoing regular colonoscopies. The standard bowel preparation regimen of 4-L polyethylene glycol (PEG) is effective but poorly tolerated.
AIM
To investigate an effective and comfortable bowel preparation regimen for hospitalized patients ≥ 50 years in age.
METHODS
Patients were randomly assigned to group 1 (2-L PEG + 30-mL lactulose + a low-residue diet) or group 2 (4-L PEG). Adequate bowel preparation was defined as a Boston bowel preparation scale (BBPS) score of ≥ 6, with a score of ≥ 2 for each segment. Non-inferiority was prespecified with a margin of 10%. Additionally, the degree of comfort was assessed based on the comfort questionnaire.
RESULTS
The proportion of patients with a BBPS score of ≥ 6 in group 1 was not significantly different from that in group 2, as demonstrated by intention-to-treat (91.2% vs 91.0%, P = 0.953) and per-protocol (91.8% vs 91.0%, P = 0.802) analyses. Furthermore, in patients ≥ 75 years in age, the proportion of BBPS scores of ≥ 6 in group 1 was not significantly different from that in group 2 (90.9% vs 97.0%, P = 0.716). Group 1 had higher comfort scores (8.85 ± 1.162 vs 7.59 ± 1.735, P < 0.001), longer sleep duration (6.86 ± 1.204 h vs 5.80 ± 1.730 h, P < 0.001), and fewer awakenings (1.42 ± 1.183 vs 2.04 ± 1.835, P = 0.026) than group 2.
CONCLUSION
For hospitalized patients ≥ 50 years in age, the bowel preparation regimen comprising 2-L PEG + 30-mL lactulose + a low-residue diet produced a cleanse that was as effective as the 4-L PEG regimen and even provided better comfort.
Upper gastrointestinal bleeding in Bangladeshi children: Analysis of 100 cases
Authors: Mazumder Md Wahiduzzaman , Benzamin Md 
Published: January 2024

BACKGROUND
Upper gastrointestinal bleeding (UGIB) is defined as bleeding that occurs proximal to the ligament of Treitz and can sometimes lead to potentially serious and life-threatening clinical situations in children. Globally, the cause of UGIB differs significantly depending on the geographic location, patient population and presence of comorbid conditions.
AIM
To observe endoscopic findings of UGIB in children at a tertiary care center of Bangladesh.
METHODS
This retrospective study was carried out in the department of Pediatric Gastroenterology and Nutrition of Bangabandhu Shiekh Mujib Medical University, a tertiary care hospital of Bangladesh, between January 2017 and January 2019. Data collected from hospital records of 100 children who were 16 years of age or younger, came with hematemesis, melena or both hematemesis and melena. All patients underwent upper gastrointestinal endoscopy (Olympus CV 1000 upper gastrointestinal video endoscope) after initial stabilization. Necessary investigations to diagnose portal hypertension and chronic liver disease with underlying causes for management purposes were also done.
RESULTS
A total of 100 patients were studied. UGIB was common in the age group 5-10 years (42%), followed by above 10 years (37%). Hematemesis was the most common presenting symptom (75%) followed by both hematemesis and melena (25%). UGIB from ruptured esophageal varices was the most common cause (65%) on UGI endoscopy followed by gastric erosion (5%) and prolapsed gastropathy (2%). We observed that 23% of children were normal after endoscopic examination.
CONCLUSION
Ruptured esophageal varices were the most common cause of UGIB in children in Bangladesh. Other causes included gastric erosions and prolapsed gastropathy syndrome.
Hemşirelik Öğrencilerinde Sağlık Okuryazarlığı Düzeyinin ve Etkileyen Faktörlerin Belirlenmesi
Authors: TEKBAŞ Serap , DAL YILMAZ Ümran , POLA Ganna 
Published: January 2024

Giriş: Sağlıklı olmayı ve sağlığı sürdürmeyi sağlayacak bilgilere erişme, anlama ve kullanma
becerilerini tanımlayan sağlık okuryazarlığı bireylerin kendi sağlığı ile ilgili doğru karar alabilme
durumu ile ilişkilidir.

Amaç: Bu çalışmada hemşirelik öğrencilerinin sağlık okuryazarlığı düzeyini ve sağlık okuryazarlığı
düzeyini etkileyen faktörlerin belirlemesi amaçlanmıştır.

Yöntem: Tanımlayıcı ve kesitsel tipteki çalışmamızın örneklem grubunu hemşirelik bölümünde
öğrenim gören 538 öğrenci oluşturmuştur. Veri toplama aracı olarak, araştırmacılar tarafından
hazırlanan kişisel bilgi formu ve yetişkin sağlık okuryazarlık ölçeği kullanılmıştır.

Bulgular: Hemşirelik öğrencilerinin yetişkin sağlık okuryazarlık ölçek puan ortanca değeri 15
olarak bulunmuştur. Birinci sınıftaki öğrencilerin yetişkin sağlık okuryazarlığı ölçek puan ortancası
diğer sınıflara göre daha düşük bulunmuştur (p
NGHIÊN CỨU MỘT SỐ YẾU TỐ ẢNH HƯỞNG ĐẾN QUÁ TRÌNH CHẾ BIẾN TRÀ XANH TỪ LÁ CHÈ TRUỒI TẠI PHÚ LỘC, THỪA THIÊN HUẾ
Authors: Nguyễn Quốc Sinh , Dương Văn Hậu , Nguyễn Văn Huế , Lê Công Danh , Võ Văn Quốc Bảo 
Published: January 2024

Trong ba loại trà chế biến từ cây chè là trà xanh, trà đen và trà ô long, trà xanh là sản phẩm được sản xuất theo phương pháp không lên men. Trong nghiên cứu này, một số yếu tố kỹ thuật làm héo, diệt men, vò chè và sấy khô của quá trình chế biến ảnh hưởng đến hàm lượng nước, chất hoà tan, tanin và chất lượng cảm quan của trà xanh đã được khảo sát. Kết quả nghiên cứu cho thấy, sản phẩm trà xanh được chế biến từ lá chè Truồi tại Phú Lộc, tỉnh Thừa Thiên Huế có chất lượng tốt khi làm héo chè ở nhiệt độ (30 - 35oC) trong thời gian 2 giờ; diệt men bằng cách sao ở nhiệt độ 160oC trong 2 phút; vò trong 12 phút và sấy khô theo 3 giai đoạn để đảm bảo chất lượng chè ở nhiệt độ 90oC - 160oC - 90o tương ứng với 3 mốc thời gian 25 phút -15 phút - 60 phút. Sản phẩm trà xanh có độ ẩm 4,97%, hàm lượng tanin 5,83 %ck chất hoà tan 28,33 %ck, trà có hương thơm, giảm độ hăng, độ chát của sản phẩm.
South Caucasus in the Phase of Russian-Ukrainian War: New Security Challenges and Possible Scenarios for Development
Authors: Karapetyan Roman 
Published: January 2024

The paper mainly examines the economic, political and military situation in the South Caucasus after the start of Russian-Ukrainian war. In the paper we are focused on the question of what kind of consequences does the Russian-Ukrainian war has on the countries of the South Caucasus. Relying on the analytical-forecasting approach, we also are trying to forecast what developments can be expected in this region. On this regard we especially look onto the facts from Armenia’s perspective. Of course, the discussion of the situation in Georgia and Azerbaijan was also under our great attention, because we also had set a task to compare the processes that took place in the three countries of the region.
The modernity of the topic can be measured, first of all, by its global political significance: Russian-Ukrainian conflict continues to be on the top of world political processes. On the other hand, it is actual when studying political and economic processes in the post-Soviet territory. By and large, as a result, the South Caucasus is a part of the European and Middle Eastern security sphere, or at least has an important role in them. Therefore, the ongoing developments in this region are not local and may also affect the European, Middle Eastern and the processes also in other regions.
Russian-Ukrainian conflict has affected on foreign policy behavior of the Southern Caucasus countries. The region is now under the turbulence zone, so we are not aware from being faced by new challenges and security issues. Since we have highly evaluated the impact of the conflict on the countries of the region, we have also tried to make certain predictions regarding possible future development scenarios, which could be as recommendations for foreign policy decision making structures of Armenia.
BIOLOGY OF STENOSTOMUM LEUCOPS (DUGES 1828) (CATENULIDA, TURBELLARIA), THE DOMINANT SPECIES OF TURBELLARIAN WORMS IN A SMALL WATER BODY OF THE UPPER VOLGA BASIN
Authors: Korgina E. 
Published: January 2024

In many hydrobiological studies, a large group of turbellarian worms is not, as a rule, given due attention,
although they are of considerable importance in the ecosystem of the water body. The biology of the development of one of the mass species of turbellarians Stenostomum leucops was studied in the pond of the forest park area during the vegetation period (from April to November) in 2019. The dynamics of the abundance and biomass of the species was studied. The maximum values of these parameters were recorded in June-July at the water temperature of 22.0ºC.
Penerapan Strategi Resolusi Konflik Oleh PT. Angkasa Pura I dan Pemerintah Kabupaten Kulon Progo Dalam Mengatasi Konflik Horizontal di Area Bandara New Yogyakarta Internasional Airport
Authors: Firmansyah Deden 
Published: January 2024

<p align="center"><strong><em> </em></strong></p><p><em>This study aims to look at the role of PT Angkasa Pura I and the Kulon Progo Regency Government in resolving horizontal conflicts that occurred around the Kulon Progo Airport development area. The role of PT Angkasa Pura I and the Kulon Progo Regency Government is important, especially in the process of the resolution stages for the success of the airport development progress. This </em><em>research</em><em> uses qualitative methods that are strengthened by conflict and conflict resolution approaches as a theoretical basis for looking more deeply into the process of conflict formation and efforts to reduce conflict. Data collection was carried out using in-depth interviews with crucial actors, both from the airport, the Kulon Progo Regency Government, and from the community. The results of the </em><em>research</em><em> show that horizontal conflict is formed by five things, namely perceptual distortion, grudges, distrust, competition/scarcity of resources, destructive criticism. Furthermore, PT Angkasa Pura I and the Kulon Progo Regency Government’s role in carrying out horizontal conflict resolution is carried out in </em><em>three</em><em> ways, namely </em><em>by conducting negotiations, local wisdom and through community empowerment</em><em>. It was also found that there was the involvement of indirect actors which increased the intensity and scale of the conflict which could become a basis for further research.</em></p><p>Kajian ini bertujuan untuk melihat peran PT Angkasa Pura I dan Pemerintah Kabupaten Kulon Progo dalam meresolusi konflik horizontal yang terjadi di sekitar area pembangunan Bandara Kulon Progo. Peran PT Angkasa Pura I dan Pemerintah Kabupaten Kulon Progo menjadi penting, khususnya pada proses tahapan-tahapan resolutif untuk mensukseskan progres pembangunan bandara tersebut. Penelitian ini menggunakan metode kualitatif yang dikuatkan dengan pendekatan konflik dan resolusi konflik sebagai basis teoretis untuk melihat lebih dalam proses terbentuknya konflik hingga upaya peredaman konflik. Pengumpulan data dilakukan dengan metode wawancara mendalam pada aktor-aktor yang krusial, baik dari pihak bandara, Pemerintah Daerah, maupun dari kalangan masyarakat. Hasil penelitian menunjukkan bahwa konflik horizontal dibentuk oleh lima hal, yakni penyimpangan persepsi, dendam, ketidakpercayaan, kompetisi/kelangkaan sumber daya, kritik yang bersifat merusak. Lebih lanjut, peran PT Angkasa Pura I dan Pemerintah Daerah Kulon Progo dalam melakukan resolusi konflik horizontal dilakukan melalui tiga cara, yakni dengan melakukan negosiasi, kearifan lokal <em>(local wisdom),</em><em> </em>dan melalui pemberdayaan masyarakat <em>(empowerment)</em>. Ditemukan pula adanya keterlibatan aktor tidak langsung yang meningkatkan intensitas dan skala konflik yang dapat menjadi pijakan bagi penelitian selanjutnya.</p>
Resección anterior ultrabaja y anastomosis laparoscópica en adenocarcinoma de recto. Reporte de un caso
Authors: Torres Antonio , Masabanda Carlos , Rivadeneira Proaño Francisco , Mesías Joseph 
Published: January 2024

Introducción: El Cáncer colorrectal es la segunda causa de muerte en el mundo occidental, en la actualidad el abordaje laparoscópico mínimamente invasivo ha mostrado beneficio sobre la cirugía convencional abierta. Caso clínico: Se informa el caso de una mujer de 53 años que presentó proctorragias de 6 meses de evolución acompañado de mucorrea y dificultad para realizar la deposición. En colonoscopia se identifica a 7 cm de borde anal lesión que ocluye los 2/3 de la luz intestinal, la biopsia reporta adenocarcinoma de recto. Se realizó laparoscopia exploratoria y resección anterior ultra baja con anastomosis término terminal más confección de ileostomía de protección. En estudio histopatológico de pieza quirúrgica reporto bordes quirúrgicos libres de tumor y 38 ganglios mesorrectales negativos para malignidad (pT2 N0 Mx). Se realizó cierre de ileostomía 2 meses después de la intervención con evolución favorable y preservación de continencia fecal. Conclusiones: Años atrás el diagnostico de Cáncer de recto suponía la amputación del órgano y del aparato esfinteriano con colostomía definitiva comprometiendo la calidad de vida y morbilidad. Las técnicas actuales a través de abordaje laparoscópico permiten una mejor resección mesorrectal obteniéndose resultados oncológicos óptimos y adecuada restitución de tránsito intestinal con anastomosis primaria y preservación del aparato esfinteriano. A pesar de la evolución tecnológica en cuanto a los medios diagnósticos es importante mejorar los protocolos para una adecuada estatificación clínica de los tumores de recto.
ANALISIS PERHITUNGAN DESAIN LAYOUT GUDANG SPAREPART KAPAL PADA KANTOR CABANG MERAK - BAKAUHEUNI PT. ASDP
Authors: Mulyati Erna , Mulyati Dini , Maniah Maniah , Hidayat Syamsu 
Published: January 2024

PT ASDP is a company engaged in the field of water transportation. Its main function is to provide access to inter-island public transportation as well as transportation access to areas that do not yet have crossings. Maintenance of ships at PT. ASDP is a must, so the speed of warehouse services in providing spare parts is important. Currently, the spare parts storage warehouse belongs to a third party (BGR warehouse) which shows a large accumulation of goods. This will result in damage if the spare part has a limited-service life and an increase in warehouse rental costs on third parties. Therefore, PT ASDP plans to transfer its spare parts to branch warehouses in Merak and Bakauheuni. This study aims to determine the layout design of the ship spare parts warehouse for PT ASDP branch offices in Merak and Bakauheuni using the class-based storage method, along with the calculation of the needs of using racks and bins. The result of the study is the layout design of the Bakauheni and Merak branch warehouses along with racking and bin needs that can be used as a reference for PT. ASDP in simplifying the process of inbound and outbound spare parts.
PENGARUH FINANCIAL LEVERAGE DAN UKURAN PERUSAHAAN TERHADAP NILAI PERUSAHAAN DENGAN PENGUNGKAPAN PELAPORAN TERINTEGRASI SEBAGAI VARIABEL INTERVENING
Authors: Suryo Medianto , Maulana Dikdik 
Published: January 2024

Perusahaan adalah sebuah organisasi yang mencakup sekelompok individu yang bekerja sama untuk mencapai tujuan organisasi. Nilai perusahaan yang tinggi merupakan keinginan pemilik perusahaan, karena nilai yang tinggi menunjukkan bahwa kekayaan pemegang saham juga tinggi Investor juga lebih tertarik untuk menanamkan sahamnya pada perusahaan yang memiliki prospek bagus untuk meningkatkan shareholder value, tujuan dari penelitian ini adalah untuk mengetahui ada atau tidaknya pengaruh Financial Leverage dan Ukuran Perusahaan, terhadap Nilai Perusahaan dengan Pengungkapan Pelaporan Terintegrasi sebagai Variabel Intervening. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif. Data populasi yang digunakan dalam penelitian ini adalah seluruh perusahaan yang terdaftar di Bursa Efek Indonesia pada periode 2019 berjumlah 671 perusahaan, serta pengambilan sampel dengan teknik purposive sampling dengan kriteria tertentu. Teknik analisis data yang digunakan dalam penelitian ini adalah koefisien korelasi, uji normalitas data, analisis jalur, analisis regresi linier sederhana, analisis koefisien determinasi, uji-t dan uji-f. Perhitungan statistik menggunakan SPSS for windows version 22. Penelitian ini menunjukkan bahwa Financial Leverage dan Ukuran Perusahaan berpengaruh terhadap Nilai Perusahaan dengan Pengungkapan Pelaporan Terintegrasi sebagai Variabel Intervening dan telah berpengaruh secara parsial.
ANALISIS DAN RANCANGAN SISTEM INFORMASI MONITORING PIUTANG PELANGGAN BISNIS MENGGUNAKAN WHATSAPP GATEWAY API
Authors: Armiati Sari , Mulyati Khairaningrum , Wiranda Adi Tiya 
Published: January 2024

PT XYZ as a company engaged in the service sector has services for sending letters and packages on credit to partners who already have cooperation agreements. Every incoming shipment from partners will become receivable, then the company records each incoming receivable so that it is monitored so that partners do not pay receivables beyond the due date. Activities that support the management of receivables are reporting of each receivable to determine the amount and maturity of the receivable. The current accounts receivable management business process is still semi-computed, therefore it is necessary to have a special system that can manage accounts receivable activities properly so that they can be controlled from period to period by providing receivable notification features to partners.
In this study, which is part of the development of a receivables information system, which is reflected in the financial rules regarding receivables. Research activities are carried out in the analysis phase and the information system design phase. Information system analysis uses Porter's value chain to describe ongoing activities and BPMN notation to model the main activity business processes. As for the design is done using an object-oriented approach. In designing this system, the tools used to describe processes and databases are designed using the Unified Modeling Language (UML) which provides accounts receivable management features, notifications using Whatsapp chat media and accounts receivable reporting features.
The output of the research is in the form of a report on the design of an information system for monitoring receivables using the Whatsapp Gateway API, software documents and research publications. The design of the information system built can make it easier for system developers to build management systems and monitor receivables at PT XYZ.