bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burden of late effects in a nationwide sample of long‐term breast cancer survivors
Authors: Smedsland Solveig K. , Falk Ragnhild S. , Reinertsen Kristin V. , Kiserud Cecilie E. , Brekke Mette , Bøhn Synne H. , Dahl Alv A. , Vandraas Kathrine F. 
Published: September 2023

AbstractBackgroundLong‐term breast cancer survivors (BCSs) may experience several late effects (LEs) simultaneously. This study aimed to identify subgroups of 8‐year BCSs with higher burden of LEs who could benefit from closer survivorship care, explore variables associated with higher symptom burden, and describe how symptom burden may affect general functioning.MethodsAll Norwegian women aged 20 to 65 years when diagnosed with stage I‐III breast cancer in 2011 and 2012 were invited (n = 2803). The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire/BR23, the Fatigue Questionnaire, Assessment of Survivor Concerns, and Scale for Chemotherapy Induced Long‐term Neurotoxicity were used to assess 10 common LEs and general functioning. Using latent class analysis, subgroups of BCSs with similar burden of LEs were identified. Multinominal regression analysis were performed to examine variables associated with higher symptom burden.ResultsThe final sample consisted of 1353 BCSs; 46% had low, 37% medium, and 17% high symptom burden. Younger age, short education, axillary dissection, higher systemic treatment burden, higher body mass index, and physical inactivity were associated with higher symptom burden. General functioning scores were lower, and the proportion on disability pension were higher among BCSs in the two most burdened subgroups compared with those in the low burden subgroup.ConclusionMore than half of long‐term BCSs suffered from medium or high symptom burden and experienced impaired general functioning compared with BCS with low symptom burden. Younger age and systemic treatment were important risk factors for higher symptom burden. BCSs at risk of higher symptom burdens should be identified and offered closer and extended survivorship care.
Adduct‐Type Compounds for Nonlinear Optical Crystals
Authors: Wang Chao , Yang Shunda , Luo Min 
Published: September 2023

AbstractThe performance prerequisites for nonlinear optical (NLO) crystals encompass a substantial second‐harmonic generation (SHG), a considerable laser induced damage threshold, and a moderate degree of birefringence. Nevertheless, the presence of particular anions may result in deficiencies within certain properties. The utilization of mixed anionic groups has emerged as an effective strategy to achieve a balance among numerous performance parameters of NLO crystals, particularly in terms of SHG responses and bandgaps. Compared with other heteroanionic compounds, adduct‐type compounds feature more concise structures with specific properties. Herein, we aim to provide an overview of the recent advancements in adduct‐type NLO crystals, focusing on their structures and properties. Furthermore, we analyze the coordination chemistry and disadvantages involved in adducts, and discuss the current synthesis methods as well as future directions for further exploration.
Sequential Recognition of Bisulfate and Acetate by a Ruthenium(II) Complex: Experimental and Theoretical Studies
Authors: Bazany‐Rodríguez Iván. J. , García‐Rojas Liliana Margarita , Guadalupe Hernández José , Thangarasu Pandiyan 
Published: September 2023

AbstractNew complex [RuLCl2(PPh3)] (L=N,N‐bis(2‐hydroxy‐5‐nitrobenzaldehyde)‐2,2’‐diaminodiethylamine) was prepared and characterized analytically and was employed as a luminescent chemosensor for the detection of anions. The results show that [RuLCl2(PPh3)] can detect HSO4− and AcO− selectively and in sequential order in H2O‐CH3CN (8 : 2, v/v) at pH 7.0. The spectral binding, titration, and interference analyses reveal that the addition of HSO4− to [RuLCl2(PPh3)] results in an intense fluorescence emission (IF/I0=6.55). This shows that HSO4− interacts suitably with the complex to switch ON the fluorescence which could be explained by inhibition of a PET mechanism as the above addition forms [RuLCl(HSO4)(PPh3)] in the excited state. Selectivity interaction of complex [RuLCl2(PPh3)] with HSO4− results in the formation of [RuLCl(HSO4)(PPh3)] in water but the system exhibits negligible change in its emission except for AcO−, which enhances fluorescence intensity. For the addition of AcO− to [RuLCl2(PPh3)], the system [RuLCl(AcO)(PPh3)] is formed, however, the adding of HSO4− to [RuLCl(AcO)(PPh3)] does not show any change in the intensity, suggesting that there exists a logic gate function for the addition of HSO4− followed by AcO− to [RuLCl2(PPh3)]. This finding is interesting because [RuLCl2(PPh3)] can act as a fast selective chemosensor for the sequential detection of HSO4− and AcO−.
Persistence of neuropsychiatric symptoms and dementia prognostication: A comparison of three operational case definitions of mild behavioral impairment
Authors: Guan Dylan X. , Smith Eric E. , Pike G. Bruce , Ismail Zahinoor 
Published: September 2023

AbstractINTRODUCTIONWe compared three operational case definitions of mild behavioral impairment (MBI) in the context of MBI prevalence estimates and dementia risk modeling.METHODSParticipants were dementia‐free older adults (n = 13701) from the National Alzheimer's Coordinating Center. Operational case definitions of MBI were generated based on neuropsychiatric symptoms at one (OV), two‐consecutive (TCV), or more than two‐thirds (TTV) of dementia‐free study visits. Definitions were compared in prevalence and in Cox regressions using MBI to predict incident dementia.RESULTSOV MBI was the most prevalent (54.4%), followed by TCV (32.3%) and TTV (26.7%) MBI. However, OV MBI had the lowest rate of incident dementia (hazard ratio [HR] = 2.54, 95% confidence interval [CI]: 2.33–2.78) and generated poorer model metrics than TCV MBI (HR = 4.06, 95% CI: 3.74–4.40) and TTV MBI (HR = 5.77, 95% CI: 5.32–6.26).DISCUSSIONCase ascertainment with longer timeframe MBI operational case definitions may more accurately define groups at risk of dementia in datasets lacking tools designed to detect MBI.Highlights
Mild behavioral impairment (MBI) can identify older adults at risk of dementia.
Neuropsychiatric symptom (NPS) assessment tools can be proxy measures for MBI.
Hazard for dementia was highest for MBI defined by NPS presence at more than two‐thirds of visits.
Evolution of endoglucanase genes in subterranean and surface isopod crustaceans from Central Western Australia
Authors: Javidkar Mohammad , Cooper Steven J. B. , Shokri Bousjein Nahid , Humphreys William F. , King Rachael A. , Austin Andrew D. 
Published: September 2023

AbstractRecent studies have identified a significant number of endogenous cellulase genes in various arthropods, including isopods, allowing them to process hydrocarbons efficiently as a food source. While this research has provided insight into underlying gene‐level processes in cellulose decomposition by arthropods, little is known about the existence and expression of cellulase genes in species from cave environments where carbohydrates are sparse. To investigate whether endogenous cellulase genes are maintained in subterranean species, we sequenced the transcriptomes of two subterranean paraplatyarthrid isopod species from calcrete (carbonate) aquifers of central Western Australia and a related surface isopod species. Seven protein‐coding open‐reading frames associated with endoglucanase genes were identified in all species. Orthology inference analyses, using a wide range of cellulase sequences from available databases, supported the endogenous origin of the putative endoglucanase genes. Selection analyses revealed that these genes are primarily subject to purifying selection in most of the sites for both surface and subterranean isopod species, indicating that they are likely to encode functional peptides. Furthermore, evolutionary branch models supported the hypothesis of an adaptive shift in selective pressure acting on the subterranean lineages compared with the ancestral lineage and surface species. Branch‐site models also revealed a few amino acid sites on the subterranean branches to be under positive selection, suggesting the acquisition of novel adaptations to the subterranean environments. These findings also imply that hydrocarbons exist in subsurface aquifers, albeit at reduced levels, and have been utilized by subterranean isopods as a source of energy for millions of years.
Seasonal variability of lotic macroinvertebrate communities at the habitat scale demonstrates the value of discriminating fine sediment fractions in ecological assessments
Authors: Mathers Kate L. , Armitage Patrick D. , Hill Matthew , McKenzie Morwenna , Pardo Isabel , Wood Paul J. 
Published: September 2023

AbstractDespite lotic systems demonstrating high levels of seasonal and spatial variability, most research and biomonitoring practices do not consider seasonality when interpreting results and are typically focused at the meso‐scale (combined pool/riffle samples) rather than considering habitat patch dynamics. We therefore sought to determine if the sampling season (spring, summer and autumn) influenced observed macroinvertebrate biodiversity, structure and function at the habitat unit scale (determined by substrate composition), and if this in turn influenced the assessment of fine sediment (sand and silt) pressures. We found that biodiversity supported at the habitat level was not seasonally consistent with the contribution of nestedness and turnover in structuring communities varying seasonally. Habitat differences in community composition were evident for taxonomic communities regardless of the season but were not seasonally consistent for functional communities, and, notably, season explained a greater amount of variance in functional community composition than the habitat unit. Macroinvertebrate biodiversity supported by silt habitats demonstrated strong seasonal differences and communities were functionally comparable to sand habitats in spring and to gravel habitats in autumn. Sand communities were impoverished compared to other habitats regardless of the season. Silt habitats demonstrated a strong increase in Ephemeroptera, Plecoptera and Trichoptera (EPT) taxa and functional richness from spring into autumn, while vegetation habitats displayed a peak in EPT abundance in summer. Only silt and sand habitats demonstrated temporal variability in functional evenness suggesting that these habitats are different in terms of their resource partitioning and productivity over time compared to other habitats. Gravel and vegetation habitats appeared to be more stable over time with functional richness and evenness remaining consistent. To accurately evaluate the influence of fine sediment on lotic ecosystems, it is imperative that routine biomonitoring and scientific research discriminate between sand and silt fractions, given they support different biodiversity, particularly during summer and autumn months.
Inhaled nitric oxide testing in predicting prognosis in pulmonary hypertension due to left‐sided heart diseases
Authors: Satoh Taijyu , Yaoita Nobuhiro , Nochioka Kotaro , Tatebe Shunsuke , Hayashi Hideka , Yamamoto Saori , Sato Haruka , Takahama Hiroyuki , Suzuki Hideaki , Terui Yosuke , Yamada Kaito , Yamada Yusuke , Inoue Takumi , Aoki Tatsuo , Satoh Kimio , Sugimura Koichiro , Miyata Satoshi , Yasuda Satoshi 
Published: September 2023

AbstractAimsThe pathophysiology of pulmonary hypertension (PH) due to left‐sided heart disease (Group 2 PH) is distinct from that of other groups of PH, yet there are still no approved therapies that selectively target pulmonary circulation. The increase in pulmonary capillary pressure due to left‐sided heart disease is a trigger event for physical and biological alterations of the pulmonary circulation, including the nitric oxide (NO)–soluble guanylate cyclase–cyclic guanosine monophosphate axis. This study investigated inhaled NO vasoreactivity tests for patients with Group 2 PH and hypothesized that these changes may have a prognostic impact.Methods and resultsThis was a single‐centre, retrospective study with a median follow‐up of 365 days. From January 2011 to December 2015, we studied 69 patients with Group 2 PH [age, 61.5 ± 13.0 (standard deviation) years; male:female, 49:20; left ventricular ejection fraction, 50.1 ± 20.4%; mean pulmonary arterial pressure, ≥25 mmHg; and pulmonary arterial wedge pressure (PAWP), >15 mmHg]. No adverse events were observed after NO inhalation. Thirty‐four patients with Group 2 PH showed increased PAWP (ΔPAWP: 3.26 ± 2.22 mmHg), while the remaining 35 patients did not (ΔPAWP: −2.11 ± 2.29 mmHg). Multivariate analysis revealed that increased PAWP was the only significant predictor of all‐cause death or hospitalization for heart failure (HF) after 1 year (hazard ratio 4.35; 95% confidence interval, 1.27–14.83; P = 0.019). The acute response of PAWP to NO differed between HF with preserved and reduced ejection fractions.ConclusionsPatients with Group 2 PH were tolerant of the inhaled NO test. NO‐induced PAWP is a novel prognostic indicator.
Post‐hypoxic status epilepticus – A distinct subtype of status epilepticus with poor prognosis
Authors: Orav Kateriine , Bosque Varela Pilar , Prüwasser Tanja , Machegger Lukas , Leitinger Markus , Trinka Eugen , Kuchukhidze Giorgi 
Published: September 2023

AbstractObjectiveTo evaluate the clinical outcome of patients with possible and definitive post‐hypoxic status epilepticus (SE) and to describe the SE types in patients with definitive post‐hypoxic SE.MethodsPatients with definitive or possible SE resulting from hypoxic brain injury after cardiac arrest (CA) were prospectively recruited. Intermittent EEG was used for the diagnosis of SE according to clinical practice. Two raters blinded to outcome analyzed EEGs retrospectively for possible and definitive SE patterns and background features (frequency, continuity, reactivity, and voltage). Definitive SE was classified according to semiology (ILAE). Mortality and Cerebral Performance Categories (CPC) score were evaluated 1 month after CA.ResultsWe included 64 patients of whom 92% died. Among the survivors, only one patient had a good neurological outcome (CPC 1). No patient survived with a burst suppression pattern, low voltage, or electro‐cerebral silence in any EEG. Possible or definitive SE was diagnosed in a median of 47 h (IQR 39–72 h) after CA. EEG criteria for definitive electrographic SE were fulfilled in 39% of patients; in 38% – for electroclinical SE and in 23% – for ictal‐interictal continuum (IIC). The outcome did not differ significantly between the three groups. The only patient with good functional outcome belonged to the IIC group. Comatose non‐convulsive SE (NCSE) without subtle motor phenomenon occurred in 20% of patients with definitive electrographic SE and outcome was similar to other types of SE.SignificancePossible or definitive SE due to hypoxic brain injury is associated with poor prognosis. The outcome of patients with electrographic SE, electroclinical SE, and IIC did not differ significantly. Outcome was similar in patients with definitive electrographic SE with and without prominent motor features.
Dose response of transcranial near infrared light stimulation on brain functional connectivity and cognition in older adults—A randomized comparison
Authors: Joshi Himanshu , Sinha Preeti , Bowers Dawn , John John P. 
Published: September 2023

AbstractPhotobiomodulation, also called low‐level light therapy, has been reported in animal studies to have an effect on brain activity and cognition. However, studies in humans regarding its effect on cognition and brain functional connectivity, and the required dose threshold for achieving the same have been very limited. We compared the effects of different doses of photobiomodulation (PBM) on cognition and resting state brain functional connectivity in 25 cognitively normal adults aged 55–70 years. They were randomized to a single session of the sham group, “low‐dose” and “high‐dose” groups receiving NIR light with transcranial fluence of 26 and 52 J/cm2 respectively, and intranasal fluence of 9 and 18 J/cm2 respectively. There was a significant increase in resting state functional connectivity of the left superior frontal gyrus (SFG) with the left planum temporale (PT), p = 0.0016, and with the left inferior frontal gyrus, pars triangularis, p = 0.0235 in the “high‐dose” group only compared to the “sham” group. There was also a significant improvement in visual search and processing speed (p = 0.012) in the “high‐dose” group. Replication of these findings in an adequately powered randomized sham‐controlled study in healthy older adults can pave the way for clinical application of NIRL as a therapeutic modality in patients with Alzheimer's disease.
Self‐regulatory control processes in youths: A temporal network analysis approach
Authors: Turri Fiorella , Jones Andrew , Constanty Lauriane , Ranjbar Setareh , Drexl Konstantin , Miano Giorgia , Lepage Caroline , Plessen Kerstin Jessica , Urben Sébastien 
Published: September 2023

AbstractObjectiveThis study aimed to better understand the temporal interrelationships among self‐control, response inhibition, and anger (i.e., momentary state and rumination) on both the within‐ and between‐person levels in male adolescents.MethodWe applied temporal network analyses among 62 male adolescents with a wide range of behavioral difficulties. Self‐control, momentary anger, and anger rumination were mapped by self‐report measures, whereas we measured response inhibition through an ambulatory Go/No‐go task (two measures a day—morning and afternoon—over a 9‐day period).ResultsTemporal network analysis, at the within‐person level, revealed that morning measures of response inhibition, anger rumination, and self‐control were related to the corresponding measure in the afternoon. More efficient response inhibition in the morning was associated with higher self‐control in the afternoon. Higher anger rumination in the morning led to higher momentary anger in the afternoon. In a concurrent within‐person network, higher momentary anger was reciprocally associated with lower self‐control. At the between‐person level, higher momentary anger was correlated to higher anger rumination, lower response inhibition, and lower self‐control.DiscussionThis study provides insight into the dynamic interactions among self‐control, response inhibition, and anger (momentary state and rumination) in male adolescents, advancing the understanding of self‐regulatory control functioning.
Perceptions of the dental education‐wide climate: Analysis of the 2022 ADEA climate study focus groups
Authors: Escontrías Omar A. , Escontrías Gabriel , West Karen P. 
Published: September 2023

AbstractObjectiveClimate assessments in higher and postsecondary education institutions are essential in landscaping inclusiveness and belonging for students, faculty, and staff. Although some climate assessments in dental education have been conducted either as part of their own campus or parent university climate assessment, a dental education‐wide climate study has not been conducted across dental schools and allied dental education programs in the United States and Canada.MethodsAs integral part of the 2022 ADEA Climate Survey in Dental Education, focus groups were conducted from March to April 2022 to ascertain the perceptions of students, faculty, and staff in dental education. A phenomenological study on 85 focus group participants comprised of students, faculty, and staff at U.S. and Canadian dental schools and allied dental education programs was conducted. Thematic analyses were structured on four overarching categories: (1) belonging, (2). bias, (3) challenges and barriers, and (4) future recommendations.ResultsSeveral themes emerged across all groups. The lack of inclusion and belonging on campuses, deficit of faculty of color, microaggressions and differential treatment of students of color, and the need to enhance recruitment of diverse students and faculty of color were among themes identified. Exclusive to U.S. allied dental education programs, exposure to unique community and clinical opportunities for students was identified as an important theme to enhance diversity, equity, inclusion, and belonging (DEIB).ConclusionThe first‐ever dental education‐wide climate study exposes the need to undertake this initiative in academic dentistry. The ongoing challenges unveiled in this study offer an opportunity to identify solutions that are meaningful, inclusive, impactful, and that foster humanistic learning environments for students, faculty, and staff in dental education.
Spatial and temporal characteristics of past droughts in New Brunswick (1971–2020)
Authors: Poirier Charlotte , Fortin Guillaume , Dubreuil Vincent 
Published: September 2023

AbstractThis study aimed to provide a historical picture from 1971 to 2020 of the state of droughts in New Brunswick (NB). More specifically, we wished to determine whether there were statistically significant trends using two drought indices: the Standardized Precipitation Index (SPI) and the Standardized Precipitation‐Evapotranspiration Index (SPEI). Monthly precipitation (rain and snow) and average maximum and minimum temperatures were obtained from 10 stations located in New Brunswick. Then, we applied Mann–Kendall and Sen's Slope's nonparametric tests to these two indices at a 1‐, 3‐, 6‐ and 12‐month timescale. The results have shown that the average value for the SPI and SPEI evolution throughout the study period indicated a decrease in indices values (at 95% confidence level). The temporal evolution of the SPI and SPEI were similar at various timescales regarding severities and intensities. However, there were still slight differences in the fluctuation values, especially during the last 20 years of the study period. At a 12‐month timescale, both indices indicated the driest years as being 2020, 2001 and 2004. The SPEI Miramichi, Saint John and Moncton stations had maximum negative MK values (−0.259, −0.221 and −0.215), respectively. As for spatial distribution, four stations located in the south stood out with the highest increase in dry conditions and significantly negative trends (meaning increased drought in this case). Stations in the northern part of the province (Bathurst and Charlo) show non‐significant trends. This study suggests a slight drought increase trend exists in New Brunswick, while an increase in annual precipitation is expected between 42 and 324 mm by 2100 according to climate scenario RCP8.5 of CMIP6.