bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluoreszierende Stoffe aus Roten Waldameisen der Gattung Formica (INS. HYM). 6. Mitteilung [1]. Einige chemische Eigenschaften des Formicapterins
Authors: Viscontini M. , Konishi M. 
Published: December 2004

AbstractFormicapterin wurde aus Formica rufa und F. polyctena isoliert. Die Ergebnisse der physikalisch‐chemischen Messungen und der Abbaureaktionen, die am verfügbaren Material ausgeführt wurden, erlauben noch keine endgültige Aussage über die Struktur des Formicapterins, das vermutlich ein polyhydroxyliertes Lumazin ist.
Struktur der Blei(IV)‐carboxylate und ihre Zersetzung über elektronenspinresonanz‐spektroskopisch nachweisbare Radikalzwischenstufen
Authors: Heusler K. , Loeliger H. 
Published: December 2004

AbstractThe position of the asymmetric COO‐ vibration of lead4+ carboxylates (at 6.50 to 6.58 μ) clearly indicates the absence of covalent bonding between oxygen and lead. These salts show strong UV. absorption in the region of 220 to 270 nm which is assigned to a charge transfer from oxygen to lead. UV.‐irradiation of lead4+ carboxylates at −196°C in a solid benzene matrix leads to decarboxylation and production of alkyl radicals which were identified by ESR. spectrometry. These radicals react in the solid matrix by hydrogen abstraction from the α‐position of a neighbouring carboxylate. In solution however rapid oxidation to carbonium ions occurs.
Das Problem der Mononitrierung von Durol
Authors: Hanna S. B. , Hunziker E. , Saito T. , Zollinger H. 
Published: December 2004

AbstractIn contrast to many previous investigations, reaction conditions were found under which the nitration of durene (nitrating ratio of 1:1) gives predominantly, and in high yield, mononitrodurene rather than the usually formed dinitrodurene (plus unreacted durene). The method consists in nitrating by nitronium phosphorohexafluoride in nitromethane as solvent in presence of two equivalents of water.With mixed acid (HNO3 + H2SO4) in nitromethane and in acetonitrile durene forms also monoand no dinitrodurene; but under most conditions by‐products are formed. Some of the by‐products were identified.Some preliminary mechanistic results are reported: An addition complex of unknown structure is formed rapidly; 3, 6‐dideuterodurene + D2O do not show a hydrogen isotope effect; the preferential formation of dinitrodurene under conventional conditions is due to the fact that the reaction occurs at encounter‐controlled rate.
Strahlungschemie von Kohlenwasserstoffen. 15. Mitteilung. Energieübertragung im System Benzol–3‐Phenylcyclohexadien‐(1,4)
Authors: Zimmerli Bernhard , Gäumann Tino 
Published: December 2004

Abstract3‐Phenylcyclohexa‐1,4‐diene, which is a reaction product in the benzene radiolysis, is decomposed when its solutions in benzene are irradiated by γ‐rays. The main products are biphenyl (20%) and dihydrobenzene (10%). They show that hydrogen from phenylcyclohexadiene is transferred to benzene. The high G‐value for the disappearance is explained by energy‐transfer from a high‐lying state of benzene, formed with g(B*) ≥ 2, to the diene. From the concentration dependence in the range 0.015–0.25 Mol/1 can be concluded that τ · ktA is 21 1/Mole for phenylcyclohexadiene and 4 1/mole for cyclohexene, where τ is the lifetime of the excited state of benzene involved in the reaction and ktA is the rate constant for energy‐transfer from this excited state to the acceptor. This rate constant is in the same order of magnitude for biphenyl, naphthalene and cyclohexa‐1,4‐diene as accepted for phenylcyclohexadiene. The nature of the energy transfer from benzene to phenylcyclohexadiene is discussed. The possibilities of charge transfer or the lowest singlet‐ or tripletstate as excited states are ruled out.
Groupes de départ inhabituels lors de cyclisations dans la série des quinoxalines, II [1]
Authors: Dahn H. , Nussbaum Jeannine 
Published: December 2004

AbstractQuinoxaline‐3‐ketones substituted by different groups in position 2 (I) are easily cyclized by hydroxylamine and phenylhydrazine to form isoxazolo[4, 5‐b] quinoxalines (II) and pyrazolo [3, 4‐b] quinoxalines (III) respectively. The reactions proceed via the oximes resp. phenylhydrazones. Groups displaced are not only the customary leaving groups of aromatic SN2 reactions (halogens, OH), but likewise H, COOH, CONH2, CO‐Ar, and, less easily, benzyl groups; methyl and phenyl groups were not displaced. The displacement of hydride ion in the presence of excess of hydroxylamine resp. phenylhydrazine is explained in terms of an extension of the theory of osazone formation.
Über die Chiralität der enantiomeren cis‐Tetrahydro‐actinidiolide
Authors: Ribi M. , Eugster C. H. 
Published: December 2004

AbstractAusgehend von (+) R‐α‐Cyclogeraniumsäure wurde die (+) R‐α‐Homocyclogeraniumsäure und daraus durch Jodlactonisierung und Hydrogenolyse (1R: 2 S)‐2, 6, 6‐Trimethyl‐2‐hydroxy‐cyclohexanessigsäure‐lacton ((+)‐cis‐Tetrahydro‐actinidiolid) hergestellt.
Etudes sur les composés organométalliques V [1]. Action de la pyridine sur les organomagnésiens
Authors: Dubsky George Jon , Jacot‐Guillarmod André 
Published: December 2004

AbstractBy the action of pyridine on various Grignard reagents at room temperature, new diorganomagnesium complexes R2Mg · 2pyridine (R=Ph, n‐Bu, t‐Bu and Et) were prepared and analyzed. Anomalous results were obtained with methyl‐ or benzylmagnesium reagents.
Calotropis‐Glykoside, vermutliche Teilstruktur.. Glykoside und Aglykone, 321. Mitteilung
Authors: Brüschweiler F. , Stöckel K. , Reichstein T. 
Published: December 2004

AbstractReduction of uscharidin (19) with NaBH4 gave a crystalline product C29H42O9 which we formulate as β‐tetrahydro‐uscharidin (12), it was characterised as a crystalline tri‐O‐acetyl‐derivative 14. The same compound 12 was obtained from calactin (18) and calotropin (18A), thus confirming earlier results of HESSE et al. about the close interrelationship of the three compounds. New formulae are suggested for the 7 Calotropis glycosides: calactin (18), calotropin (18A), uscharidin (19), calotoxin (20), procerosid (21), uscharin (31), and voruscharin (32). These formulae are consistent with the chemical reactions and spectra of the mentioned compounds. They are constructed in analogy to the formula of gomphoside (11) advanced by WATSON et al. with only an additional oxo group at C‐19.
Zur Thermodynamik der Metallcarbonate 3. Mitteilung [1]. Löslichkeitskonstanten und Freie Bildungsenthalpien von ZnCO3 und Zn5(OH)6(CO3)2 bei 25°
Authors: Schindler P. , Reinert M. , Gamsjäger H. 
Published: December 2004

AbstractThe solubilities of ZnCO3 and Zn5(OH)6(CO3)2 have been investigated at 25°C in solutions of the constant ionic strength 0,2 M consisting primarily of sodium perchlorate. From experimental data the following values for equilibrium constants and GIBBS free energies of formation are deduced:

A predominance area diagram for the ternary system Zn2+–H2O–CO2(g) including ZnO, ZnCO3, Zn5(OH)6(CO3)2, and Zn2+ is given.
Eine präparative Synthese von Streptozotocin
Authors: Hardegger E. , Meier A. , Stoos A. 
Published: December 2004

AbstractDurch Umsetzung von D‐Glucosamin mit dem bisher unbekannten N‐Nitroso‐methylcarbamylazid (VII) wurde das Beta‐Zytotoxin Streptozotocin (VIII) synthetisch präparativ zugänglich gemacht.
Über die Stabilitätsbereiche der Bleisalze des 2,4,6‐Trinitroresorcins in wässeriger Lösung
Authors: Durtschi A. , Rauber W. , Aebi F. 
Published: December 2004

AbstractDas 2,4,6‐Trinitroresorcin (  H2Tric) bildet ausser den bereits bekannten Bleisalzen PbTric · H2O und Pb2(OH)2 Tric noch die Verbindungen Pb5(OH)6Tric2 und Pb13O7(OH)8Tric2. Diese Niederschläge wurden aus Pb(ClO4)2‐Lösungen durch Zugabe von NaOH und Trinitroresorcin erzeugt. Die überstehenden Lösungen waren 0,2 M an NaClO4. Nach zehnmonatiger Versuchsdauer wurde in ihnen – log[Pb]total, – log[Tric]total und – log[H+] bestimmt. Daraus wurden für die Löslichkeitskonstanten

folgende Werte bestimmt:

Bodenkörper
−log*L
Bodenkörper
−log*L

PbTric · H2O
5,35 ± 0,06
Pb5(OH6)Tric2
−1,26 ± 0,15

Pb2(OH)2Tric
−0,40 ± 0,25
Pb13O7(OH)8Tric2
−7,96 ± 0,19

Pb5(OH)6Tric2
−2,36
PbO · Pb(OH)2
−12,33 ± 0,09

Die Werte der linken Spalte sind nur im Bereich – log[H+] ⩽ 8,5, die der rechten nur im Bereich – log[H+] ≥ 11,0 gültig.Aus diesen Daten wurde das Prädominanzdiagramm mit den Achsen – log[H+], – log[Pb]total und – log[Tric]total gezeichnet. Das Diagramm wird bei höheren pH‐Werten durch das PbO · Pb(OH)2 abgeschlossen.
Synthese des «Thyrotropin‐releasing» Hormons (TRH) (Schaf) und verwandter Peptide
Authors: Gillessen D. , Lergier W. , Studer R. O. , Felix A. M. 
Published: December 2004

AbstractThe syntheses of seven tripeptide isomers containing L‐histidine, L‐proline and L‐glutamic acid residues, the same as found in the natural thyrotropin‐releasing hormone (TRH), are reported. In addition L‐pyroglutamyl‐L‐histidyl‐L‐proline and its amide as well as Nα‐acetyl‐L‐glutamyl‐L‐histidyl‐L‐proline are described. Whereas eight peptides are inactive and L‐pyroglutamyl‐L‐histidyl‐L‐proline shows a slight TRH activity, L‐pyroglutamyl‐L‐histidyl‐L‐proline‐amide has the full biological activity of the isolated thyrotropin‐releasing hormone and, at the present state of knowledge, seems to be identical with it.
Reaktionen von α‐Chlorcarbonsäurechloriden mit Trialkylaminen
Authors: Giger R. , Allain R. , Rey M. , Dreiding A. S. 
Published: December 2004

AbstractThe condensation of α,α‐dichloropropionyl chloride (IVa) and of trichloroacetyl chloride (IVb) with α‐chloropropionyl chloride (Ia) in the presence of triethylamine led to two acid chloride enol‐esters, both as mixtures of cis‐ and trans‐isomers, namely 1, 2‐dichloropropenyl α,α‐dichloropropionate (Va) and 1, 2‐dichloropropenyl trichloroacetate (Vb).A mixture of triethylamine and trichloroacetyl chloride produced an oxidation‐reduction reaction to give 48% 1, 2, 2, 2‐tetrachloroethyltrichloroacetate (VIII) and 69% 1‐diethylamino‐4, 4, 4‐trichloro‐1‐butene‐3‐one (IX). Basic hydrolysis of IX led to 43% of glutaconic acid (XIII). Tripropylamine reacted in the same way with trichloroacetyl chloride to yield 1‐dipropylamino‐2‐methyl‐4, 4, 4‐trichloro‐but‐1‐ene‐3‐one (XIX) which was readily hydrolyzed in acid solution to α‐trichloroacetyl‐propionaldehyde (XX).
Isolierunǵ von (‐)‐allo‐Muscarin aus Amanita muscaria. 33. Mitteilung über Inhaltsstoffe von Fliegenpilzen
Authors: Schleusener E. , Eugster C. H. 
Published: December 2004

AbstractAus Fliegenpilzen (Amanita muscaria) wurde (–)‐allo‐Muscarin isoliert.
Russula‐Farbstoffe: Erkennung der roten Hauptkomponenten als dimere Pteridinǵlykoside; Trennung von Pterinen durch isoelektrische Fokussierung in einem pH‐Saccharose‐Gradienten. Vorläufige Mitteilung
Authors: Euǵaster C. H. , Frauenfelder E. F. , Koch H. 
Published: December 2004

AbstractThe genus Russula is rich in colourless, yellow and red pteridine derivatives. The main dyestuffs of the pileus of the red species (R. emetica, badia, sardonia, obscura, paludosa) are recognized as glycosides of dimeric pteridine derivatives. The main component is a D‐riboside. It has been named Russupteridin‐sIII. The chromophore is very similar to that of rhodopterine (pterorhodine; I).Rhodopterine has been cleaved by aqueous ammonia to give xanthopterine and 7‐methyl‐xanthopterine, respectively.The new technique of isoelectric focusing using a pH and sucrose gradient [7] [8] effectively separated pterines and Russula‐dyestuffs. Preparative separation was achieved by means of a sephadex G25 chromatographic column using pyridine‐water as a eluant.
Photochemische Darstellung von Hexaalkylborazol‐und Aromaten‐chromtricarbonylen
Authors: Deckelmann K. , Werner H. 
Published: December 2004

AbstractThe half‐sandwich type complexes LCr(CO)3 (L=(C2H5)3B3N3(CH3)3, (CH3)3B3N3(C2H5)3, C6H6, sym‐C6H3(CH3)3) have been prepared by photochemical reaction of Cr(CO)6 with the appropriate ligand L at highly reduced pressure. This new method is of particular advantage for the synthesis of the hexaalkylborazole complexes.
Utilisation d'ylides du phosphore non stabilisés en chimie des sucres. IV. Nouveaux exemples de sucres méthylthiovinyliques terminaux. Communication préliminaire
Authors: Tronchet J. M. J. , Le‐Hong N. , Perret F. 
Published: December 2004

AbstractThe previously described one‐carbon chain extension of aldehydo‐sugars with methylthiomethylene‐triphenylphosphorane has been successfully applied to an anhydro‐aldehydo‐sugar and two w‐aldehydo‐sugars. Some spectroscopic properties of the so obtained methylthiovinylic sugars are given.
Über Pterinchemie. 28. Mitteilung. Hydroxylierung von Phenylalanin zu Tyrosin mittels Tetrahydropterin unter physiologischen Bedingungen
Authors: Viscontini M. , Mattern G. 
Published: December 2004

AbstractEs werden die Versuche und Ergebnisse beschrieben, die zur Entwicklung der Theorie eines Radikalmechanismus für die Hydroxylierung des Phenylalanins mittels Tetrahydropterin unter physiologischen Bedingungen beigetragen haben.
Untersuchungen über das Verhalten organischer Mischphasen 9. Mitteilung Vergleich der binären Systeme Tetrahydrofuran mit Wasser, Methanol und Cyclohexan, Diäthyläther mit Wasser, Methanol und Cyclohexan und Tetrahydrofuran‐Diäthyläther
Authors: Arm H. 
Published: December 2004

AbstractActivities and mixing functions of the following binary systems at 25° C are discussed: 1. mixtures of tetrahydrofuran with water, methanol, and cyclohexane; 2. mixtures of diethyl ether with water, methanol, and cyclohexane, and 3. mixtures of tetrahydrofuran with diethyl ether. Comparison with similar systems shows that in systems containing methanol, the strongest interactions are formation and breaking of hydrogen bonds between alcohol molecules; interactions between methanol and ether molecules play a minor rǒle. Systems containing water exhibit two main kinds of interaction: formation and breaking of hydrogen bonds between water molecules, and formation of hydrogen bonds between water and ether molecules. Deviations from ideality are larger for diethyl ether than for tetrahydrofuran in water and methanol, and smaller in cyclohexane.
Synthese von terpenartigen bicyclischen Systemen über die Cycloaddition von Dimethylketen an Methylcyclopentadien
Authors: Huber Ulrich A. , Dreiding André S. 
Published: December 2004

AbstractThe structure of the cyclo‐addition products of ketenes (2) and methylcyclopentadiene could not be predicted, since this ketenophile exists as a rapidly equilibrating 45:54:1 mixture of the 1‐ (4), 2‐ (5) and 5‐methyl (6) isomers. We studied this reaction using dimethylketene (2a) with a view to monoterpenoid synthesis. Only two (A and B) of the many possible cyclo‐adducts were formed in good yield. Using three methods to generate dimethylketene, the ratios of A:B were 90:6, 77:16 and 55:31 respectively.The structures of A and B were proved without making use of the known ketene cyclo‐addition rules: Of the many possibilities, all but 7, 8, 9 and 10 were excluded by the CO and CCCH3 IR.‐bands and NMR. signals. Structure 7 (filifolone) was rejected by the difference of its NMR. spectrum from those of both A and B, leaving only 8, 9 and 10.For A, structures 9 and 10 were eliminated by two chemical approaches: (1) Peracetic acid oxidation of a mixture rich in A resulted in a combination of Baeyer‐Villiger reaction, epoxidation, and epoxide‐ketone rearrangement affording a C10‐keto‐lactone 14, which was cleaved by alkali to acetone and a C7‐keto‐acid 18. (2) Another peracetic acid treatment produced a keto‐epoxide 11, which was converted to a diol 22 and then to a diketo‐aldehyde 23 with an NMR. doublet for the aldehyde proton.Of the two structures (9 and 10) left for B, the latter was excluded by the NMR. spectrum of keto‐epoxide 15 isolated from the peracid treatment of a mixture rich in B: A decoupling experiment with 15 showed that the ‐CH2‐ was placed next to the α‐carbon of the carbonyl function.Thus the major cyclo‐adduct of dimethylketene and methylcyclopentadiene is 8, and the minor product is 9. This result demonstrates further ketene cyclo‐addition specificities on top of the ones expressed by the three known rules. The different ratios of 8 : 9 are considered to be due to varyingly effective competition between the preliminary interconversion of the methylcyclopentadienes and their cyclo‐addition of dimethylkctene.A number of other oxidation and reduction products of 8 are described. One of them proved that C7 had migrated in the Baeyer‐Villiger reaction.A partial separation of the enantiomers of the major cycloadduct 8 was achieved. By the use of 0.5 equivalent of three chiral primary amines (31, 32, and 33) to form a Schiff base, the excess ketone 8 was in each case distilled off in a chirally enriched form with positive optical rotation. The derived 2.3‐dihydroketone 36 was shown to have a positive Cotton effect and, by an application of the octant rule, to have the (1R,5S) chirality orientation.
Contribution à la connaissance des o‐menthols et des o‐menthones (carquéjanols et carquéjanones). 2e communication
Authors: Ferretti‐Alloise Maria‐Giulia , Jacot‐Guillarmod André , Naves Yves‐René 
Published: December 2004

Abstract(+)‐Carquejanone and (‐)‐isocarquejanone have been described by their IR. spectra and configurationally studied by optical rotatory dispersion and circular dichroism (Cotton effect). The application of the octant rule confirms the configurations previously assigned by Thomas.
The Pyrolysis of Fur‐2‐ylmethyl Vinyl Ethers
Authors: Thomas Alan F. 
Published: December 2004

AbstractThe pyrolysis of fur‐2‐ylmethyl vinyl ether and its next highest homologue, the propenyl ether, is described. Products from two reaction mechanisms are observed namely a 3‐substituted 2‐methylfuran from an electrocyclic mechanism, and 1,2‐di‐(fur‐2‐yl)‐ethane and furylpropanal from a biradical mechanism.
Die nucleofuge Aktivität von Substituenten am Brückenkopf von Bicyclo[2.2.2]octan und Chinuclidin Das kOTs/kBr‐Verhältnis als mechanistisches Kriterium. Fragmentierungsreaktionen, 24. Mitteilung
Authors: Grob C. A. , Kostka K. , Kuhnen F. 
Published: December 2004

AbstractThe rate ratios kOTs/kBr of the bridgehead tosylate and bromide of bicyclo [2.2.2]‐octane and quinuclidine, respectively, have been determined in 80 vol.‐% ethanol. The high ratio for the bicyclo [2.2.2] octane derivatives (3,3 · 103 at 25°) indicates a highly ionic transition state. Since nucleophilic assistance to ionisation by solvent is precluded in this system a ratio of 103 or greater is typical for the «limiting» SN1 mechanism. Lower kOTs/kBr ratios therefore reflect increasing nucleophilic participation in the transition state of substitution and elimination reactions.The high kOTs/kBr ratio for 4‐substituted quinuclidines, namely 1,6 · 103 at 25°, indicates the absence of anchimeric nitrogen participation in the transition state of this synchronous fragmentation. The rates of the 4‐haloquinuclidines follow the normal order of nucleofugal activity for halides in solvolysis reactions.
Etude théorique et possibilités d'application de la méthode de «variations continues» [1] aux complexes très dissociés
Authors: Marcantonatos M. , Buffle R. , Monnier D. 
Published: December 2004

AbstractA theoretical study of the possibilities of applicability to very unstable complexes of the «continuous variation» principle shows that the general equation of a theoretical Job's curve can be reduced, for limiting values of x and 1 − x (x being the ligand's mole fraction), to expressions permitting the determination of the number «m» of the central groupes, the number «n» of the ligands, and the stability constants of highly dissociated complexes. Theoretical and practical limitations are discussed.
C‐Glycosides II. Synthèse d'un analogue de la pyrazomycine. Communication préliminaire
Authors: Tronchet J. M. J. , Perret Mlle F. 
Published: December 2004

AbstractA synthesis of 3‐β‐D‐erythro‐furanosyl‐1‐p‐nitrophenyl‐pyrazole is described.
Der geschwindigkeitsbestimmende Schritt bei der Decarboxy‐lierung von 2,4‐Dihydroxybenzoesäure in mässig konzentrierter wässeriger Salzsäure
Authors: Willi A. V. , Cho M. H. , Won C. M. 
Published: December 2004

AbstractThe decarboxylation kinetics of 2,4‐dihydroxybenzoic acid have been studied in 0.1–8 N aqueous HCl at 50°. At low HCl concentrations, the observed first order rate constant, k, increases with increasing acidity of the solution. In solutions with 3.5–6 N HCl, k remains constant.The D2O solvent isotope effect decreases from kH2O/kD2O = 2.0 in 1N HCl to 1.3 in 5 N HCl, and it remains unchanged at 1.3 if the HCl concentration is increased further to 8 N.It is concluded that an increase of the acidity of the solution causes a change of the rate determining step from slow proton transfer to rate limiting CC bond cleavage.
Totalsynthese des Antibioticums Anisomycin
Authors: Felner I. , Schenker K. 
Published: December 2004

AbstractThe synthesis of the antibiotic anisomycin (1) is described. In the key step 3, 4‐dimethoxy‐thiopyrrolidone (16), prepared from diethyl L‐( + )‐tartarate (4) was converted to the thioiminoester 18, which upon treatment with trimethylphosphite yielded the benzylidene derivative 19. Cleavage of the ester group of 19 and hydrogenation of the decarboxylation product gave the two isomers 21 and 22. 22 was converted into desacetylanisomycin (3) and anisomycin (1).
Über Pterinchemie. 31. Mitteilung [1]. Hydroxylierung von Tryptophan mittels Tetrahydropterin unter physiologischen Bedingungen
Authors: Viscontini M. , Mattern G. 
Published: December 2004

AbstractDie experimentelle Arbeit der 21., vorläufigen Mitteilung [3] wird beschrieben. Dort wurde gezeigt, dass Tryptophan an der Luft in wässeriger Lösung mittels Tetrahydropterin und Eisen (II) als Sauerstoffaktivator unter physiologischen Bedingungen hydroxyliert wird, wobei 5‐Hydroxytryptophan, Melanine, Kynurenin, 3‐Hydroxykynurenin, Xanthommatin u. a. isoliert werden können.
Synthèse de quelques dérivés de l'amino‐3‐didésoxy‐3, 5‐D‐lyxose Communication préliminaire
Authors: Tronchet J. M. J. , Graf R. 
Published: December 2004

AbstractLAH reduction of 3, 5‐dideoxy‐1, 2‐O‐isopropylidene‐β‐D‐threo‐pentofuranose‐3‐ulose oxime leads with a high stereoselectivity to 3‐amino‐3, 5‐dideoxy‐1, 2‐O‐isopropylidene‐β‐D‐lyxofuranose. Some derivatives of the latter compound are described.
Synthèse d'analogues partiellement saturés de l'amitriptyline à partir d'ortho‐tolunitriles. 2e Communication sur les antidépresseurs et les neuroleptiques tricycliques [1]
Authors: Dostert P. , Kyburz E. 
Published: December 2004

AbstractSubstituted o‐tolunitriles are alkylated with 1‐bromomethyl‐cyclohexene. Saponification yields substituted o‐[2‐(1‐cyclohexen‐1‐yl)‐ethyl]‐benzoic acids, which are cyclised to 1,2,3,4,10,11‐hexahydro‐5H‐dibenzo[a,d]cyclohepten‐5‐ones. Reaction of the latter with (3‐dimethylamino‐propyl)‐magnesium chloride yields, after dehydration, hexahydro derivatives of the known antidepressant amitriptyline. The position of the double bonds remains uncertain.
Über die Synthese von O‐Glycyl‐N‐(2, 3, 4‐trihydroxybenzyl)‐hydroxylamin‐dihydrobromid
Authors: Hegedüs B. , Krassó A. F. 
Published: December 2004

AbstractThe synthesis of O‐glycyl‐N‐(2, 3, 4‐trihydroxybenzyl)‐hydroxylamine dihydrobromide (3) starting from carbobenzoxy‐glycine and tritylhydroxylamine is described. In contrast to the corresponding isosteric hydrazine derivative 1, 3 is no decarboxylase inhibitor.