bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constitutionalism in the Anthropocene: Compliance of International Environmental Law (IEL) Instruments
Authors: Apriani Atika Sari Diah , Triatmodjo Marsudi , Purwanto Harry 
Published: January 2025

Abstract
The constitutionalism paradigm is based on the idea that certain norms and obligations imposed on parties for environmental protection through law, especially human rights to the environment have the potential to provide global environmental protection. The aim of this research is to examine international environmental legal norms that have the potential to possess the highest hierarchy in international law through an Anthropocene approach. This research adopted a normative methodology with legislative and conceptual approaches. The research Qindings indicate that the anthropocentric approach must be compatible with the earth system perspective in order to effectively respond to the ongoing transformations of the earth system. Law serves as a tool to descriptively and normatively explain reality and to regulate the interests of all living beings, including humans. Thus, the existence of humans as legal subjects can describe the material reality of human existence in a descriptively normative manner. Constitutionalism is an attempt to determine the existence of norms that are hierarchically higher than other norms. Normative hierarchy theory postulates that the core of certain norms articulates the basic values of international society at the top of the hierarchy of international legal norms.
Digital Twin for Vibration Monitoring of Pelton Units
Authors: Boden M , Chiarelli M , Tsingos V , Allaban N , Decaix J , Stojanovic-Roth S , Blommaert G , Valluy B , Münch-Alligné C 
Published: January 2025

Abstract
The development of a digital twin to simulate the vibrational behaviour of a Pelton hydropower unit during startups offers significant potential for enhanced maintenance by detecting early warning signs of anomalies. The proposed methodology, combining high-frequency vibrational data acquisition with an offline digital twin to improve data interpretation, is applied in this study to a 15MW horizontal dual Pelton unit located in the Swiss Alps. The digital twin models fluid-structure interactions during startup with a combination of CFD simulations and transient FEM analysis, predicting the vibrational response of the unit. This numerical model allows investigating the effect of specific anomalous cases, such as jet misalignment, on the excited frequencies of the runner, enabling the creation of a library of frequency responses for predictive maintenance. Experimental modal analysis and in-situ vibration data acquisition validate the numerical model. Preliminary results show the effectiveness of this approach in understanding and predicting the vibrational behaviour of a Pelton unit during startup. Further refinement is needed, especially in conducting transient modal analysis of the full runner and shaft line, which will be conducted as part of the Horizon ReHydro project.
Green catalysts AuNPs/CQDs from turmeric starch: an effective solution in 4-Nitrophenol reduction
Authors: Le Thi Hoa , Anh Ta Thi Ngoc , Huong Nguyen Thi Thu , Thanh Nhi Le Thi , Nguyen Quoc Hien , Tran Thai Hoa 
Published: January 2025

Abstract
This paper presents a green synthesis method for growing carbon quantum dots (CQDs) from turmeric starch. The CQDs were then used as reducing agents and stabilizers to synthesize dual-shaped gold nanoparticles (AuNPs) with spherical and triangular shapes. In addition to the advantages of CQDs in catalysis, such as their large surface area and the presence of functional groups, including hydroxyl (-OH) and carbonyl (-C=O), as evidenced by FTIR analysis, the material also demonstrates excellent electron transfer efficiency. This efficiency is attributed to the synergistic interaction between AuNPs and the functional groups on CQDs, facilitating catalytic electron transfer processes in reducing 4-nitrophenol (4-NP). Furthermore, the obtained AuNPs/CQDs material benefits from the plasmonic properties of AuNPs, enhancing light absorption and accelerating catalytic reactions. As a result, AuNPs/CQDs have been successfully applied to effectively catalyze the reduction of 4-NP in aqueous media with high efficiency. The synergy between the plasmonic effect of AuNPs and the catalytic properties of CQDs results in a high catalytic efficiency and a fast reaction time of 20 min, making this method simple, rapid, scalable, and highly effective for environmental pollution remediation.
Can residential energy systems withstand the heat? Quantifying solar photovoltaic and heat pump yields for future New Zealand climate conditions
Authors: Zegeer Madison L , Peer Rebecca A M , Haas Jannik 
Published: January 2025

Abstract
We investigate how higher temperatures resulting from climate change impact the energy system. Specifically, we examine the cumulative effects of fluctuating solar photovoltaic (PV) generation performance, heating and cooling demand, and heat pump efficiency on such days. To achieve this, we used the climate analogue space, which maps a given city’s future climate to an existing one. By employing climate analogues, we can predict the impact of higher temperatures by 2050, transforming Auckland, New Zealand’s climate into one akin to Sydney, Australia. This approach avoids reliance on historical weather data, which many energy system models use. We used this future climate time series as an input to a residential energy system model for Auckland, New Zealand. The residential energy system model simulates solar PV generation output via mapping of experimental data, building thermal characteristics via grey-box resistance–capacitance (RC) modelling, and hourly coefficient of performance for air source heat pumps (ASHP) via linear regression. Our findings revealed that a future climate doubles the cooling demand and reduces the heating demand by one-third, with the heat pump demand peak load projected to be 40% higher than current demand. Although solar PV generation experiences a decrease in efficiency of 8%, there is a 40% increase in annual direct usage of ASHP. Despite the high cooling demand, the combined yearly electricity demand for heating and cooling decreased by 6.5% overall, and the system saw a 50% improvement in demand fulfilment. However, the system performance volatility at hotter-than-normal temperatures and the potential for significant energy shortfalls remain concerns. The shift from a predominantly heating to a cooling environment is a critical design condition that should be considered in energy expansion planning and future electrification. The framework and time series developed in this work can be expanded and applied to other energy system modelling exercises.
Management of invasive populations
Authors: Phillips Ben 
Published: January 2025

Abstract
This chapter develops four diverse case studies: an invasive species; tumour growth; gene drives; and the spread of a pathogen. The chapter shows how all these cases can be understood as invasions, and it examines how the theory that has been developed might be applied to managing such invasions. The chapter maps existing management strategies to theory and shows how an evolutionary perspective can allow the development of novel management strategies.
The Battle and the Arrival of Self-Advocacy
Authors: Briggs Jonathyne 
Published: January 2025

Abstract
This chapter details the continued challenges facing autistic persons in France in the twenty-first century, as well as recent developments of advocacy groups run by autistic people that counter the entrenched stereotypes of autism in France. Diagnosis and treatment of autism has become the center of a cultural war in France, with social, political, and legal ramifications. Psychoanalysts were put on the defensive thanks to advocates who directly challenged their authority and position. The definition of autism in France further diverged from that of other countries. This difference led the French government to take a greater interest in autism in the form of identifying it as a national cause in 2012, even as medical professionals remained entrenched in their methods of treatment. The appearance of prominent autistic self-advocates suggested a powerful shift in the framework of the debate, which had to this point been dominated by the viewpoints of professionals.
Historical and Contemporary Examples of Power, Privilege, and Public Health for Classroom Teaching
Authors: Dean Lorraine T 
Published: January 2025

Abstract
This chapter offers concrete examples of how public health research and practice have been complicit in advancing oppressive structures or have been co-opted to do so. Examples date back to the medicalization of responses to oppression through pathologies like “drapetomania,” how scientific progress has been prioritized above ethical practice, how public health and medical training and accreditation have contributed to oppression, and how infectious disease prevention was used to advance racial oppression. Contemporary examples include the use of public health insurance policies to limit the movement of foreign-born persons and promote anti-immigration rhetoric, state-sanctioned forced sterilizations of incarcerated and nonincarcerated persons, and how individuals are criminalized for the health care system’s failures. Examples are presented as case studies and vignettes that can be used in classroom-based activities for how to detect and avoid oppressive actions in future public health work.
Queer Reckonings with International Law
Authors: Biddolph Caitlin 
Published: January 2025

Abstract
Chapter 6 concludes the book by considering the broader possibilities for queering international law. Synthesizing the main findings and arguments developed across the book and through the case of the International Criminal Tribunal for the former Yugoslavia (ICTY), the chapter presents a queer approach and imagining of international law that recognizes hope, violence, and the power of queer critique. Drawing on examples from various international legal contexts and justice movements, the chapter argues that any critique of international law must reckon with calls for law by victims and survivors, but that law is necessarily limited and violent, by virtue of its gendered, sexual, and civilizational hierarchies. The chapter also suggests, however, that queer reckonings with international law can hold this seeming contradiction together: that as a (queer) governance mechanism, international law is both violent and queer, a site of (in)justice and a vocabulary that will be both used and resisted.
Housing adaptations and older adults’ health trajectories by level of initial health: evidence from the English Longitudinal Study of Ageing
Authors: Wu Jiawei , Grundy Emily M 
Published: January 2025

Abstract

Background
In many ageing societies, the housing stock is poorly designed to meet the needs of older people with health limitations. Housing adaptations may enable older people to retain functional ability in the home, improve well-being and reduce the risks of falls. There is mixed evidence on whether adaptations are most beneficial for those who have limitations or whether they have a greater impact if implemented before people experience substantial disability. This study aimed to identify socio-demographic factors associated with obtaining housing adaptations and whether and how the impact of adaptations on changes in mental and physical health varied by initial level of health measured using objective indicators.

Methods
We used data from the English Longitudinal Study of Ageing to analyse socio-demographic factors associated with acquiring housing adaptations using logistic regression. We then estimated mixed-effects models to assess how a measure of baseline physical health, derived from observer-measured indicators of physical function, modified the association between acquiring housing adaptations and health and disability outcomes for two cohorts each followed up for three waves.

Results
Having more activities of daily living (ADL) limitations was positively associated with acquiring housing adaptations, but we found no evidence for socio-demographic variations. Acquiring housing adaptations was associated with slower development of instrumental ADL/ADL disability among older people with initially good latent physical health. Sensitivity analysis suggested that housing adaptations mitigated the predicted probability of falls for those with severe mobility impairments.

Conclusions
Housing adaptations may slow down development of disability in older people with initially good health.
Asiaticoside-nitric oxide synergistically accelerate diabetic wound healing by regulating key metabolites and SRC/STAT3 signaling
Authors: Mu Xingrui , Chen Jitao , Zhu Huan , Deng Junyu , Wu Xingqian , He Wenjie , Ye Penghui , Gu Rifang , Wu Youzhi , Han Felicity , Nie Xuqiang 
Published: January 2025

Abstract

Background
Diabetic wounds pose significant clinical challenges due to impaired healing processes, often resulting in chronic, non-healing ulcers. Asiaticoside (AC), a natural triterpene derivative from Centella asiatica, has demonstrated notable anti-inflammatory and wound-healing properties. However, the synergistic effects of nitric oxide (NO)—a recognized promoter of wound healing—combined with AC in treating diabetic wounds remain inadequately explored.

Methods
Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) was utilized to identify differential metabolites and dysregulated metabolic pathways associated with diabetic wounds. Molecular docking analyses were conducted to confirm the binding affinity of AC to key therapeutic targets. The effects of Asiaticoside-nitric oxide hydrogel (ACNO) on gene and protein expression were evaluated using RT-qPCR and western blotting. In vitro experiments using SRC agonists and inhibitors were performed to investigate the impact of ACNO therapy on the expression of SRC, STAT3, and other proteins in HaCaT cells.

Results
Metabolomic profiling revealed that diabetic wounds in mice exhibited marked metabolic dysregulation, which was attenuated by ACNO treatment. Key metabolites modulated by ACNO included mandelic acid, lactic acid, and 3-hydroxyisovaleric acid. The primary metabolic pathways involved were methyl histidine metabolism and the malate–aspartate shuttle. Immunofluorescence staining confirmed that ACNO therapy enhanced angiogenesis, promoted cellular proliferation, and facilitated diabetic wound closure. RT–qPCR data demonstrated that ACNO regulated the transcription of critical genes (SRC, STAT3, EGFR, and VEGFA). Notably, ACNO attenuated SRC/STAT3 pathway activation while concurrently upregulating EGFR and VEGFA expression.

Conclusions
These findings emphasize the therapeutic potential of ACNO hydrogel in diabetic wound healing through the modulation of metabolic pathways and the SRC/STAT3 signaling axis. By correlating altered metabolites with molecular targets, this study elucidates the pharmacodynamic foundation for ACNO’s pre-clinical application and provides valuable insights into the development of targeted therapies for diabetic wound management.
Association of treatment methods and survival in esophageal neuroendocrine carcinoma population of Surveillance, Epidemiology, and End Results database: a retrospective cohort study
Authors: Yang T , Yang P , Li H , Sun M , Zhang J , Li Y , Zhu B 
Published: January 2025

Summary
Esophageal neuroendocrine carcinoma (ENEC) is an uncommon and highly aggressive tumor with an obscure etiology. Thus, this study aimed to investigate the best treatment option for patients with ENEC. This study identified patients with ENEC from the Surveillance, Epidemiology, and End Results (SEER) database between 1975 and 2021. Clinicopathological characteristics were analyzed using descriptive statistics, and prognostic factors were determined through Cox regression analysis. Kaplan–Meier survival analysis was used to assess five-year overall survival (OS). Patients were divided into a combined radiotherapy and chemotherapy group and a surgery group based on treatment modality. Propensity score matching (PSM) was performed to balance baseline characteristics between the two groups. A total of 604 participants were included; univariate and multivariate analyses indicated that ENEC patients with localized or regional disease had significantly higher survival rates (HR = 0.38, 95% CI 0.29-0.51, P &lt; 0.001 and HR = 0.56, 95% CI 0.44-0.71, P &lt; 0.001) than those with distant metastases. The combination of radiotherapy and chemotherapy (HR = 0.34, 95% CI 0.25-0.46, P &lt; 0.001) and surgical treatment (HR = 0.43, 95% CI 0.31-0.59, P &lt; 0.001) significantly improved survival. Kaplan–Meier analysis showed significant differences in OS among treatments (P &lt; 0.0001), with the combination therapy and surgery groups having similar rates of 7.04% and 8.77%, respectively, and outperforming other methods. The combination therapy group maintained the best survival rate over time. The synergistic application of radiotherapy and chemotherapy has markedly enhanced the five-year survival rate of patients with ENEC, offering invaluable insights for clinical management strategies.
Association between orthodontic treatment and psychosocial factors in adolescents: a cross-sectional study
Authors: Schmahl Teresa , Steinhäuser Jost , Goetz Katja 
Published: January 2025

Abstract

Background
Orthodontic treatment is one of the longest and most common medical interventions in adolescence. There are certain inequalities in care leading to risk factors associated with higher rates of untreated tooth malocclusion, resulting in a significant burden on oral health. Little is known about that certain psychosocial and personal risk factors influence the uptake of orthodontic treatment. Therefore, the aim was to explore factors that might influence orthodontic treatment and psychosocial and personal factors in a representative sample in Germany.

Methods
The data are based on the KiGGS Survey Wave 2, a representative cross-sectional study of children and adolescents in Germany. Sociodemographic data, uptake of orthodontic treatment, parental socioeconomic status, social support, self-efficacy, and perceived health status were collected through a self-reported questionnaire.

Results
A total of 6599 children and adolescents between 11 and 17 years were included in the analysis. Girls, non-immigrants, children, and adolescents with higher levels of social support, and children and adolescents who have visited a dentist or orthodontist more often in the past 12 months are more likely to have received orthodontic treatment. Among 14- to 17-year-olds, the likelihood of seeking orthodontic treatment is also associated with an increasing parental socioeconomic status (odds ratio 1.07 [95% CI 1.02; 1.14] P = .013).

Conclusions
Certain protective and risk factors as well as personal and psychosocial factors are associated with orthodontic treatment. This knowledge can be used to determine which individuals should be targeted for need-based care to ensure that health care is provided without over- or undertreatment.
The added value of electrocardiogram abnormalities in predicting incident cardiovascular disease risk for people with Type 2 diabetes: the Hoorn Diabetes Care System cohort
Authors: Harms Peter P , Herings Reinier A R , Remmelzwaal Sharon , Rutters Femke , Beulens Joline W J , Nijpels Giel , Elders Petra P J M , Blom Marieke T 
Published: January 2025

Abstract

Aims
To investigate whether adding electrocardiogram (ECG) abnormalities as a predictor improves the performance of incident cardiovascular disease (CVD) risk prediction models for people with Type 2 diabetes (T2D).

Methods and results
We evaluated the four major prediction models that are recommended by the guidelines of the American College of Cardiology/American Heart Association and European Society of Cardiology, in 11 224 people with T2D without CVD (coronary heart disease, heart failure, stroke, and thrombosis) from the Hoorn Diabetes Care System cohort (1998–2018). Baseline measurements included CVD risk factors and ECG recordings coded according to the Minnesota Classification as no, minor, or major abnormalities. After confirming good reference model fit, model performance was assessed before and after addition of ECG abnormalities and compared using c-statistics, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). c-statistics [95% confidence interval (CI)] of reference models (ASCVD, AD-ON, ADVANCE, and SCORE2-Diabetes) were 0.67 (0.65–0.70), 0.73 (0.71–0.76), 0.71 (0.68–0.74), and 0.67 (0.65–0.69), respectively. Adding ECG abnormalities as a predictor improved c-statistics with +0.02 (0.01–0.03), +0.01 (0.00–0.01), +0.02 (0.01–0.03), and +0.02 (0.01–0.02), respectively. Reclassification indicators also showed improvement: categorical NRI (+6%, +3%, +8%, and +5%, respectively), continuous NRI (95% CI) [0.25 (0.08–0.37), 0.32 (0.23–0.42), 0.54 (0.34–0.69), and 0.28 (0.09–0.33)], respectively, and IDI (95% CI) [0.005 (0.001–0.010), 0.002 (−0.001–0.007), 0.006 (0.001–0.007), and 0.004 (0.000–0.006), respectively]. Sensitivity analyses yielded similar results.

Conclusion
The addition of ECG abnormalities to incident CVD risk prediction models moderately but consistently improves the ability of models to correctly classify people with T2D in the appropriate CVD risk category with up to 8%, which is approximately equivalent to many established predictors and (bio)markers.
Associations of Faith Community Rejection with Social Support and Health Outcomes among LGBTQ+ Older Adults
Authors: Lampe Nik M , McKay Tara 
Published: January 2025

Abstract

Objectives
Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) older adults have varied experiences with faith communities, ranging from affirmation to religious trauma. We investigate how faith community rejection impacts social support and health outcomes among LGBTQ+ older adults in the Southern United States.

Methods
We analyze Wave 1 data from the LGBTQ+ Social Networks, Aging, and Policy Study (QSNAPS), collected between April 2020 and September 2021. This sample included 1,256 LGBTQ+ adults aged 50+ residing in four Southern U.S. states. Bivariate and Poisson regression analyses were conducted to examine associations of LGBTQ-related faith community rejection with social support and health outcomes.

Results
Nearly half (44%) of QSNAPS respondents reported LGBTQ-related faith community rejection. Respondents who reported rejection were more likely to be: transgender or gender diverse (p&lt;0.01) and from a minoritized racial/ethnic background (p&lt;0.01). Compared with respondents who never experienced faith community rejection, respondents who experienced LGBTQ-related faith community rejection reported a lower prevalence of family support (APR=0.80; p&lt;0.001); higher prevalence of symptoms related to moderate to severe psychological distress (APR=1.27; p&lt;0.001); higher prevalence of poor sleep quality (APR=1.17; p&lt;0.05) and high blood pressure diagnosis (APR=1.13; p&lt;0.05). We also find a marginally statistically significant association between faith community rejection and higher prevalence of symptoms related to subjective cognitive decline (APR=1.35; p&lt;0.10).

Discussion
Experiences of faith community rejection come with substantial social support and health costs for LGBTQ+ older adults. Our findings highlight the importance of integrating faith and promoting inclusion within affirming faith communities for LGBTQ+ aging-related care and prevention.