bluuebunny/crossref_metadata_2025_split huggingface dataset:
The salvage role of allogeneic hematopoietic stem-cell transplantation in relapsed/refractory diffuse large B cell lymphoma
Authors: Min Gi-June , Jeon Young-Woo , Kim Tong Yoon , Kwag Daehun , Kim Byung-Su , Lee Joonyeop , Lee Jong Hyuk , Park Sung-Soo , Park Silvia , Yoon Jae-Ho , Lee Sung-Eun , Cho Byung-Sik , Eom Ki-Seong , Kim Yoo-Jin , Lee Seok , Kim Hee-Je , Min Chang-Ki , Lee Jong Wook , Cho Seok-Goo 
Published: October 2023

AbstractTo clarify the role of allogeneic hematopoietic stem-cell transplantation (allo-HSCT) in the chimeric antigen receptor T-cell therapy era, we analyzed the clinical characteristics and outcomes of 52 patients treated with allo-HSCT with relapsed/refractory diffuse large B cell lymphoma. Most enrolled patients had previously undergone intensive treatments, the median number of chemotherapy lines was 4, and the median time from diagnosis to allo-HSCT was 27.1 months. Patients were divided into remission-achieved (n = 30) and active-disease (n = 22) groups before allo-HSCT. Over a median follow-up period of 38.3 months, overall survival (OS) and event-free survival (EFS) rates were 38.4% and 30.6%, respectively. The cumulative incidence of relapse (CIR) and the non-relapsed mortality (NRM) were 36.7% and 32.7%, respectively. OS, EFS, and graft-versus-host disease-free, relapse-free survival (GRFS) outcomes were significantly superior in the remission-achieved group with lower CIR. In a multivariate analysis, a shorter interval from diagnosis to allo-HSCT reflected relatively rapid disease progression and showed significantly poor OS and EFS with higher CIR. Patients with active disease had significantly lower EFS, GRFS, and higher CIR. Previous autologous stem-cell transplantation was associated with better GRFS. Allo-HSCT is an established modality with a prominent group of cured patients and still has a role in the CAR T-cell era, particularly given its acceptable clinical outcomes in young patients with chemo-susceptible disease.
Highly nonlinear optic nucleic acid thin-solid film to generate short pulse laser
Authors: Ghasemi Marjan , Debnath Pulak Chandra , Kim Byungjoo , Pournoury Marzieh , Khazaeinezhad Reza , Hosseinzadeh Kassani Sahar , Yeom Dong-Il , Oh Kyunghwan 
Published: October 2023

AbstractUsing aqueous precursors, we report successfully fabricating thin-solid films of two nucleic acids, ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). We investigated the potential of these films deposited on a fiber optic platform as all-fiber integrated saturable absorbers (SAs) for ultrafast nonlinear optics. RNA-SA performances were comparable to those of DNA-SA in terms of its nonlinear transmission, modulation depth, and saturation intensity. Upon insertion of these devices into an Erbium-doped fiber ring-laser cavity, both RNA and DNA SAs enabled efficient passive Q-switching operation. RNA-SA application further facilitated robust mode-locking and generated a transform-limited soliton pulse, exhibiting a pulse duration of 633 femtoseconds. A detailed analysis of these pulsed laser characteristics compared RNA and DNA fiber optic SAs with other nonlinear optic materials. The findings of this research establish the feasibility of utilizing RNA as a saturable absorber in ultrafast laser systems with an equal or higher potential as DNA, which presents novel possibilities for the nonlinear photonic applications of nucleic acid thin solid films.
Design and fabrication of 3D-printed patient-specific soft tissue and bone phantoms for CT imaging
Authors: Mei Kai , Pasyar Pouyan , Geagan Michael , Liu Leening P. , Shapira Nadav , Gang Grace J. , Stayman J. Webster , Noël Peter B. 
Published: October 2023

AbstractThe objective of this study is to create patient-specific phantoms for computed tomography (CT) that possess accurate densities and exhibit visually realistic image textures. These qualities are crucial for evaluating CT performance in clinical settings. The study builds upon a previously presented 3D printing method (PixelPrint) by incorporating soft tissue and bone structures. We converted patient DICOM images directly into 3D printer instructions using PixelPrint and utilized calcium-doped filament to increase the Hounsfield unit (HU) range. Density was modeled by controlling printing speed according to volumetric filament ratio to emulate attenuation profiles. We designed micro-CT phantoms to demonstrate the reproducibility, and to determine mapping between filament ratios and HU values on clinical CT systems. Patient phantoms based on clinical cervical spine and knee examinations were manufactured and scanned with a clinical spectral CT scanner. The CT images of the patient-based phantom closely resembled original CT images in visual texture and contrast. Micro-CT analysis revealed minimal variations between prints, with an overall deviation of ± 0.8% in filament line spacing and ± 0.022 mm in line width. Measured differences between patient and phantom were less than 12 HU for soft tissue and 15 HU for bone marrow, and 514 HU for cortical bone. The calcium-doped filament accurately represented bony tissue structures across different X-ray energies in spectral CT (RMSE ranging from ± 3 to ± 28 HU, compared to 400 mg/ml hydroxyapatite). In conclusion, this study demonstrated the possibility of extending 3D-printed patient-based phantoms to soft tissue and bone structures while maintaining accurate organ geometry, image texture, and attenuation profiles.
Assessment of biomechanical behavior of immature non-vital incisors with various treatment modalities by means of three-dimensional quasi–static finite element analysis
Authors: Hassouneh Layla , Matoug-Elwerfelli Manal , Al-Omari Taher , Setzer Frank C. , Nagendrababu Venkateshbabu 
Published: October 2023

AbstractThe objectives of this study were to evaluate the stress distribution and risk of fracture of a non-vital immature maxillary central incisor subjected to various clinical procedures using finite element analysis (FEA). A three-dimensional model of an immature central incisor was developed, from which six main models were designed: untreated immature tooth (C), standard apical plug (AP), resin composite (RC), glass-fibre post (GFP), regeneration procedure (RET), and regeneration with induced root maturation (RRM). Mineral trioxide aggregate (MTA) or Biodentine®were used as an apical or coronal plug. All models simulated masticatory forces in a quasi–static approach with an oblique force of 240 Newton at a 120° to the longitudinal tooth axis. The maximum principal stress, maximum shear stress, risk of fracture, and the strengthening percentage were evaluated. The mean maximum principal stress values were highest in model C [90.3 MPa (SD = 4.4)] and lowest in the GFP models treated with either MTA and Biodentine®; 64.1 (SD = 1.7) and 64.0 (SD = 1.6) MPa, respectively. Regarding the shear stress values, the dentine tooth structure in model C [14.4 MPa (SD = 0.8)] and GFP models [15.4 MPa (SD = 1.1)] reported significantly higher maximum shear stress values compared to other tested models (p < 0.001), while no significant differences were reported between the other models (p > 0.05). No significant differences between MTA and Biodentine®regarding maximum principal stress and maximum shear stress values for each tested model (p > 0.05). A maximum strain value of 4.07E−03 and maximum displacement magnitude of 0.128 mm was recorded in model C. In terms of strengthening percentage, the GFP models were associated with the highest increase (22%). The use of a GFP improved the biomechanical performance and resulted in a lower risk of fracture of a non-vital immature maxillary central incisor in a FEA model.
The suppression of MAPK/NOX/MMP signaling prompts renoprotection conferred by prenatal naproxen in weaning preeclamptic rats
Authors: Abdelhady Sherien A. , Ali Mennatallah A. , Yacout Dalia M. , Essawy Marwa M. , Kandil Lamia S. , El-Mas Mahmoud M. 
Published: October 2023

AbstractAlthough nonsteroidal antiinflammatory drugs (NSAIDs) are frequently used for fever and pain during pregnancy, their possible interaction with perinatal renal injury induced by preeclampsia (PE) has not been addressed. Here, studies were undertaken in the N(gamma)-nitro-l-arginine methyl ester (l-NAME) PE model to assess the influence of gestational NSAIDs on renal damage in weaning dams. PE-evoked increments and decrements in urine protein and creatinine clearance, respectively, were intensified by celecoxib and weakened by diclofenac or naproxen. Naproxen also improved renal cloudy swelling, necrosis, and reduced glomerular area evoked by PE. The concomitant rises in renal expression of markers of oxidative stress (NOX2/4), extracellular matrix metaloproteinase deposition (MMP9), and prostanoids (PGE2, PGF2α, TXA2) were all more effectively reduced by naproxen compared with celecoxib or diclofenac. Western blotting showed tripled expression of mitogen-activated protein kinases (MAPKs; p-p38, p-JNK1, p-ERK1, p-ERK2) in PE kidneys that was overturned by all NSAIDs, with naproxen producing the largest drop in p-ERK2 expression. The PE-provoked elevation in renal expression of autophagic marker LC3 was reduced by naproxen and diclofenac, but not celecoxib. The data suggests superior effect for naproxen over other NSAIDs in rectifying preeclamptic renal injury and predisposing inflammatory, oxidative, autophagic, and fibrotic signals.
Alleviation role of exogenous cadaverine on cell cycle, endogenous polyamines amounts and biochemical enzyme changes in barley seedlings under drought stress
Authors: Ozmen Serkan , Tabur Selma , Oney-Birol Signem 
Published: October 2023

AbstractCadaverine (Cad), which has an independent synthesis pathway compared to other polyamine (PA) types, contributes to the health of plants by regulating plant growth and development, abiotic stress tolerance and antioxidant defense mechanisms. In this work, experiments were carried out to understand the effects of exogenous Cad (10 µM) application under drought stress (%22 PEG 6000) and without stress on cell cycle, total protein content, endogenous PA levels, and biochemical enzyme activities in barley (Hordeum vulgare cv. Burakbey) considering the potential of Cad to stimulate the drought-related tolerance system. Cad application in a stress-free environment showed an effect almost like low-impact drought stress, causing changes in all parameters examined compared to samples grown in distilled water environment (Control). The results clearly show that Cad applied against the negative effects of drought stress on all parameters creates a drought resistance mechanism of the plant. Accordingly, Cad applied together with drought stress increased the density of cells in the cell cycle (G1–S and S–G2 phases) and the amount of endogenous (spermidine 10% and spermine 40%) PAs. In addition, while superoxide dismutase (SOD) (5%), (CAT) (55%) and ascorbate peroxidase (APX) (18%) enzyme levels increased, a stress response mechanism occurred due to the decrease in total protein content (20%) and malondialdehyde (MDA) (80%). As a result, exogenous application of 10 µM Cad showed that it reduced the negative effects of drought stress on endogenous PA amounts, cell division and biochemical activities in barley.
The application of a combined stimulation with CRH and desmopressin during bilateral inferior petrosal sinus sampling in patients with Cushing's syndrome
Authors: Tsagarakis S. , Kaskarelis I. S. , Kokkoris P. , Malagari C. , Thalassinos N. 
Published: October 2023

SummaryBACKGROUND Bilateral inferior petrosal sinus sampling (BIPSS) is a useful investigative technique in the differential diagnosis of ACTH‐dependent Cushing's syndrome (CS). The diagnostic sensitivity of this procedure is improved by the administration of CRH to stimulate ACTH secretion. It has been reported recently that the combined administration of CRH and desmopressin is a more potent stimulus for ACTH release from corticotroph adenomas. We therefore hypothesized that the combined stimulation of ACTH secretion with CRH plus desmopressin may further improve the diagnostic outcome of this procedure.AIMS To report our experience of the application of combined stimulation with CRH and desmopressin during BIPSS in patients with ACTH‐dependent Cushing's syndrome, and to compare these results to those obtained in patients who have undergone BIPSS with CRH stimulation alone.PATIENTS We studied 34 patients with ACTH‐dependent CS: 30 with Cushing's disease (CD) and four with occult ectopic ACTH syndrome (oEAS). A combined stimulation with CRH (100 μg i.v.) plus desmopressin (10 μg i.v.) during BIPSS was performed in 15 patients with CD, while in a different group of 15 patients with CD, BIPSS was performed with CRH stimulation alone (100 μg i.v.). In the patients with oEAS, BIPSS was performed with CRH stimulation in three and CRH plus desmopressin in one patient.RESULTS In patients with CD the mean peak ACTH levels from the dominant petrosal sinus samples were significantly higher in the group given a combined stimulus than in the group who had only CRH stimulation (mean ± SD: 1649 ± 938 vs. 692 ± 561 ng/l, P < 0·05). Dominant inferior petrosal sinus/peripheral (IPS/P) ACTH ratios greater than 2 were observed in 15/15 (100%) patients following the combined stimulation with CRH and desmopressin and 13/15 (87%) patients undergoing stimulation with CRH alone. No patient with oEAS had an IPS/P ratio greater than 2. It is of note that the single patient with oEAS studied following a combined stimulation during BIPSS had a IPS/P ratio of less than 2, despite a significant peripheral ACTH and Cortisol response.CONCLUSIONS A combined stimulus using CRH and desmopressin appears to induce a higher ACTH output from pituitary corticotroph adenomas during BIPSS, which may improve the diagnostic sensitivity of this procedure.
The time invariant beamformer for Doppler spread suppression in high‐mobility transmission
Authors: Hu Zhinan 
Published: October 2023

AbstractBeamforming network with the Doppler suppression scheme reducing the channel time‐varying effects has attracted much research interests in high‐mobility massive MIMO communications. However, the current time‐varying beamforming network still suffers from high volatility peak‐to‐average power ratio (PAPR) fluctuations. For this reason, a time invariant compensation optimized beamformer is proposed to mitigate the peak‐to‐average power ratio high volatility and the channel time variation in the high‐mobility uplink transmission. To attain the Doppler spread and implement the Doppler spread suppression scheme, a time‐varying spectrum (TVS) is proposed and its statistical properties of time‐varying spectrum is analyzed. The simulation results are provided to verify the proposed studies.
Generation of random sea clutter amplitude sequence with quantitative control on distribution tail
Authors: Liao Xingxing , Zhou Jie , Xie Junhao 
Published: October 2023

AbstractThis letter proposes a data‐driven method to simulate random sea clutter amplitude sequence with distribution and correlation characteristics directly inherited from the measured clutter. First, a generation model is developed to simulate clutter amplitude sequence with desired distribution. By multiplying the measured amplitudes with random disturbance coefficients, the model introduces sample diversity between the simulated and measured sequences. Meanwhile, to quantitatively control the difference of the distribution tails between the simulated and measured sequences (i.e. to ensure their distributions are similar), the threshold error metric is introduced to set the disturbance variance. Second, a scheme combining the generation model with the correlation transfer technique is presented, which allows to simulate clutter amplitude sequence with both desired distribution and correlation for engineering purpose. Experiments based on different measured clutter sets indicate the proposed method works very well.
Integer codes correcting single errors and double adjacent errors
Authors: Miletic Miljan , Radonjic Aleksandar 
Published: October 2023

AbstractThe user datagram protocol is the most widely used protocol for streaming multimedia data over the Internet. Like other protocols at the network and transport layers, it uses the Internet Checksum (IC) to detect channel errors. The consequence of this is that each corrupted packet is dropped, which can degrade the quality of service perceived by a user. In this paper, the authors present a solution to this problem based on integer codes capable of correcting single and double adjacent errors. The presented codes are a generalization of the IC, which makes them easy to implement in software.
Multi‐level cross‐modality learning framework for text‐based person re‐identification
Authors: Wu Tinghui , Zhang Shuhe , Chen Dihu , Hu Haifeng 
Published: October 2023

AbstractThe target of text‐based person re‐identification (Re‐ID) is to retrieve the corresponding image of a person through the given text information. However, due to the homogeneous variety and modality heterogeneity, it is challenging to simultaneously learn both global‐level and local‐level cross‐modal features and align them in the same embedding space without additional networks. To address these problems, an effective multi‐level cross‐modality learning (MCL) framework for language and vision person Re‐ID is proposed. More specifically, a multi‐branch feature extraction (MFE) module is designed to comprehensively map both global and partial semantic information for the visual and textual embedding at the same time, capturing the intra‐class semantic relationships in multi‐granularities. Besides, a cross‐modal alignment (CA) module is devised to match the multi‐grained representations and reduce the inter‐class gap from global‐level to partial‐level. Extensive experiments conducted on the CUHK‐PEDES and ICFG‐PEDES datasets suggest that this method outperforms the state‐of‐the‐art models.
Seasonal restructuring facilitates compositional convergence of gut microbiota in free-ranging rodents
Authors: Klure Dylan M , Dearing M Denise 
Published: October 2023

Abstract
Gut microbes provide essential services to their host and shifts in their composition can impact host fitness. However, despite advances in our understanding of how microbes are assembled in the gut, we understand little about the stability of these communities within individuals, nor what factors influence its composition over the life of an animal. For this reason, we conducted a longitudinal survey of the gut microbial communities of individual free-ranging woodrats (Neotoma spp.) across a hybrid zone in the Mojave Desert, USA, using amplicon sequencing approaches to characterize gut microbial profiles and diet. We found that gut microbial communities were individualized and experienced compositional restructuring as a result of seasonal transitions and changes in diet. Turnover of gut microbiota was highest amongst bacterial subspecies and was much lower at the rank of Family, suggesting there may be selection for conservation of core microbial functions in the woodrat gut. Lastly, we identified an abundant core gut bacterial community that may aid woodrats in metabolizing a diet of plants and their specialized metabolites. These results demonstrate that the gut microbial communities of woodrats are highly dynamic and experience seasonal restructuring which may facilitate adaptive plasticity in response to changes in diet.
Crustal deformation in the southeastern margin of the Tibetan Plateau: insights from broad-band Pg-wave attenuation tomography
Authors: Li Ruo-Jie , Zhao Lian-Feng , Xie Xiao-Bi , Yao Zhen-Xing 
Published: October 2023

SUMMARY
The deformation mechanism in southeastern Tibet since the continental collision between the Indian and Eurasian plates could be explained by several models, including two major classic end-member models, the rigid-block extrusion model and the crustal flow model. Crustal channel flow is likely an important tectonic regime for properly explaining a large number of geological and geophysical observations but remains in competition with the block extrusion model. Consequently, detecting ductile flow connectivity would play a key role in understanding the tectonic evolution of the southeastern Tibetan Plateau. Here, we established a high-resolution broad-band QPg model for the crust in SE Tibet by using a joint inversion tomography method based on both single- and two-station Pg data. We verified the stability of the QPg tomography by comparing the QPg values at 1 Hz between the joint inversion and the two-station method. Two low-QPg zones were observed, isolated by the high-QPg Emeishan large igneous province (ELIP). Strong Pg attenuation beneath the Songpan-Ganzi Block and Western Sichuan Block may indicate the presence of crustal material flow due to relatively weak rheological strength. Cooled basaltic magma remnants in the inner zone of the ELIP likely block the southeastward migration of crustal materials driven by the gravity and lateral pressure gradient, and restrict the flow to the Western Sichuan Block, resulting in surface uplift and crustal thickening. Strong Pg attenuation near the Xiaojiang Fault and the Red River Fault may result from mantle upwelling in this region. Our QPg model, combined with previous results, suggests that the tectonic deformation in the southeastern Tibetan Plateau has been mainly controlled by the effects of crustal channel flow and asthenospheric upwelling since the Late Miocene.
Simulating aortic root replacement for a surgical wet laboratory in a resource-limited setting: an economical innovation
Authors: Kamal Mian Mustafa , Sohail Abdul Ahad , Qureshi Neelam Jawed , Ullah Haseeb , Shahabuddin Syed , Kamal Mian Yasir 
Published: October 2023

Abstract
Traditional cardiac surgery residency programs rely mainly on teaching surgical skills in the operating room. The increasing complexity of cardiac surgical operations on high-risk patients and the time constraints placed on residents in this surgical discipline negatively impact the learning opportunities for those residents. Simulation models, though efficient, are very expensive. In Third World Countries, they are unavailable for trainees due to financial constraints.
We have introduced an innovative and cost-effective way of simulating aortic root replacement in a wet laboratory by applying a hand-made valve conduit or ‘pencil conduit’ to a bovine heart. It is reproducible, easy to assemble, cost-effective and simple to use. It can help develop and enhance the surgical skills of residents and junior surgeons for this advanced operation, which requires a meticulous surgical technique performed within a limited time frame.
Forecasting the effective reproduction number during a pandemic: COVID-19 R
t forecasts, governmental decisions and economic implications
Authors: Vasilakis Chrysovalantis , Nikolopoulos Konstantinos 
Published: October 2023

Abstract
Accepted by: Prof. M. Zied Babai
This research empirically identifies the best-performing forecasting methods for the Effective Reproduction Number Rt of coronavirus disease 2019, the most used epidemiological parameter for policymaking during the pandemic. Furthermore, based on the most accurate forecasts for the United Kingdom, we model the excess exports and imports during the pandemic (using World Trade Organization data), whilst simultaneously controlling for governmental decisions, i.e. lockdown(s) and vaccination. We provide empirical evidence that the longer the lockdown lasts, the larger the cost to the economy is, predominantly for international trade. We show that imposing a lockdown leads to exports falling by 16.55% in the United Kingdom; without a lockdown, the respective decrease for the same period would be only 1.57%. On the other hand, efforts towards fast population vaccination improve the economy. We believe our results can help policymakers to make better decisions before and during future pandemics.