bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical composition of horse hooves with functional qualities for competing barefoot
Authors: Spörndly-Nees Ellinor , Jansson Anna , Pökelmann Mette , Pickova Jana , Ringmark Sara 
Published: October 2023

Abstract
Barefoot racing is a common practice within the harness racing industry, but not all horses have hooves of sufficient quality to race sustainably without shoes. There is currently no objective approach available to assess whether a horse’s hooves are suitable for barefoot racing, raising animal welfare issues if trainers misjudge the functional qualities of hooves. This study compared chemical composition of the hoof wall and fatty acid (FA) composition of the digital cushion in a group of horses that had raced barefoot often (RB) and a group of horses that could not race barefoot and therefore raced with shoes (RS). Trimmings from the hind hoof wall were collected from the lateral quarters in one sub-cohort postmortem and in another sub-cohort of live horses and analyzed for macro- and microelements, nitrogen, dry matter (DM), and total and free amino acid content. For the postmortem horses, samples of the digital cushion were also collected and analyzed for total and free FAs. RB horses had lower concentrations of copper in the hoof wall (17.5 ± 3.9 vs. 32.8 ± 4.7 mg/kg DM, P = 0.02) than RS horses. RB horses also tended (P &lt; 0.1) to have higher concentrations of nitrogen (164.2 ± 0.2 vs. 163.5 ± 0.3 g/kg DM) and sulfur (22.9 ± 0.2 vs. 22.3 ± 0.3 g/kg DM). RB horses had higher hoof wall concentrations of arginine (10.51 ± 0.05 vs. 10.34 ± 0.06 g/100 g DM, P = 0.03) and showed a trend (P &lt; 0.1) for higher hoof wall concentrations of cysteine (6.14 ± 0.10 vs. 5.82 ± 0.13 g/100 g DM) and proline (4.62 ± 0.05 vs. 4.49 ± 0.06 g/100 g DM). There were no differences between the groups for any other element or amino acid analyzed. There were also no differences between the two groups in terms of FA composition of the digital cushion. These results indicate that chemical composition, especially with respect to copper, arginine, nitrogen, sulfur, cysteine, and proline, may be important for the functional qualities of the hoof capsule and the ability to race barefoot without wearing the hoof down. However, chemical analysis of hoof wall tissue and of the fat content of the digital cushion does not seem to be a definitive method for distinguishing horses that have hooves suitable for barefoot racing from those that do not.
Fragmentation and dynamics of dense gas structures in the proximity of massive young stellar object W42-MME
Authors: Bhadari N K , Dewangan L K , Pirogov L E , Pazukhin A G , Zinchenko I I , Maity A K , Sharma Saurabh 
Published: October 2023

ABSTRACT
We present an analysis of the dense gas structures in the immediate surroundings of the massive young stellar object (MYSO) W42-MME, using the high-resolution (0″.31 × 0″.25) Atacama Large Millimetre/submillimetre Array dust continuum and molecular line data. We performed a dendrogram analysis of H13CO+ (4–3) line data to study multiscale structures and their spatio–kinematic properties, and analysed the fragmentation and dynamics of dense structures down to ∼2000 au scale. Our results reveal 19 dense gas structures, out of which 12 are leaves and 7 are branches in dendrogram terminology. These structures exhibit transonic–supersonic gas motions (1$\lt \mathcal {M}\lt 5$) with overvirial states (αvir ≥ 2). The non-thermal velocity dispersion–size relation (σnt–L) of dendrogram structures shows a weak negative correlation, while the velocity dispersion across the sky ($\delta \mathit {V_{\rm lsr}}$) correlates positively with structure size (L). Velocity structure function (S2(l)1/2) analysis of H13CO+ data reveals strong power-law dependences with lag (l) up to a scale length of ≲6000 au. The mass–size (M–R) relation of dendrogram structures shows a positive correlation with power-law index of 1.73 ± 0.23, and the leaf L17 hosting W42-MME meets the mass–size conditions for massive star formation. Blue asymmetry is observed in the H12CO+ (4–3) line profiles of most of the leaves, indicating infall. Overall, our results observationally support the hierarchical and chaotic collapse scenario in the proximity of the MYSO W42-MME.
Type-A quasi-periodic oscillation in the black hole transient MAXI J1348−630
Authors: Zhang Liang , Méndez Mariano , García Federico , Zhang Yuexin , Ma Ruican , Altamirano Diego , Yang Zi-Xu , Ma Xiang , Tao Lian , Huang Yue , Jia Shumei , Zhang Shuang-Nan , Qu Jinlu , Song Liming , Zhang Shu 
Published: October 2023

ABSTRACT
We present a detailed analysis of the spectral and timing characteristics of a 7-Hz type-A quasi-periodic oscillation (QPO) detected in NICER observations of the black hole X-ray binary MAXI J1348−630 during its high-soft state. The QPO is broad and weak, with an integrated fractional rms amplitude of 0.9 per cent in the 0.5–10 keV band. Thanks to the large effective area of NICER, combined with the high flux of the source and a relatively long accumulative exposure time, we construct the first rms and phase-lag spectra for a type-A QPO. Our analysis reveals that the fractional rms amplitude of the QPO increases with energy from below 1 per cent at 1 keV to ∼3 per cent at 6 keV. The shape of the QPO spectrum is similar to that of the Comptonized component, suggesting that the Comptonized region is driving the variability. The phase lags at the QPO frequency are always soft taking the lowest energy as reference. By jointly fitting the time-averaged spectrum of the source and the rms and phase-lag spectra of the QPO with the time-dependent Comptonization model vkompthdk, we find that the radiative properties of the type-A QPO can be explained by a vertically extended Comptonized region with a size of ∼2300 km.
Extreme photometric and polarimetric variability of blazar S4 0954+65 at its maximum optical and γ-ray brightness levels
Authors: Raiteri C M , Villata M , Carnerero M I , Savchenko S S , Kurtanidze S O , Vlasyuk V V , Marchini A , Matsumoto K , Lorey C , Joner M D , Gazeas K , Carosati D , Mirzaqulov D O , Acosta Pulido J A , Agudo I , Bachev R , Benítez E , Borman G A , Calcidese P , Chen W P , Damljanovic G , Ehgamberdiev S A , Elsässer D , Feige M , Frasca A , Gaur H , Grishina T S , Gupta A C , Hiriart D , Holland M , Horst B , Ibryamov S , Ivanidze R Z , Jensen J , Jithesh V , Jovanovic M D , Kiehlmann S , Kimeridze G N , Kishore S , Kopatskaya E N , Kurtanidze O M , Larionova E G , Lin H C , Mannheim K , Marinelli C , Moreira Reyes J , Morozova D A , Nikolashvili M G , Reinhart D , Romanov F D , Semkov E , Seufert J , Shishkina E V , Sigua L A , Skalidis R , Spiridonova O I , Stojanovic M , Strigachev A , Troitskaya Y V , Troitskiy I S , Tsai A , Vasilyev A A , Vince O , Vrontaki K , Wani K , Watts D , Zhovtan A V 
Published: October 2023

ABSTRACT
In 2022 the BL Lac object S4 0954+65 underwent a major variability phase, reaching its historical maximum brightness in the optical and γ-ray bands. We present optical photometric and polarimetric data acquired by the Whole Earth Blazar Telescope (WEBT) Collaboration from 2022 April 6 to July 6. Many episodes of unprecedented fast variability were detected, implying an upper limit to the size of the emitting region as low as $10^{-4}$ parsec. The WEBT data show rapid variability in both the degree and angle of polarization. We analyse different models to explain the polarization behaviour in the framework of a twisting jet model, which assumes that the long-term trend of the flux is produced by variations in the emitting region viewing angle. All the models can reproduce the average trend of the polarization degree, and can account for its general anticorrelation with the flux, but the dispersion of the data requires the presence of intrinsic mechanisms, such as turbulence, shocks, or magnetic reconnection. The WEBT optical data are compared to γ-ray data from the Fermi satellite. These are analysed with both fixed and adaptive binning procedures. We show that the strong correlation between optical and γ-ray data without measurable delay assumes different slopes in faint and high brightness states, and this is compatible with a scenario where in faint states we mainly see the imprint of the geometrical effects, while in bright states the synchrotron self-Compton process dominates.
Envelope ejection and the transition to homologous expansion in common-envelope events
Authors: Valsan Vinaya , Borges Sarah V , Prust Logan , Chang Philip 
Published: October 2023

ABSTRACT
We conduct a long-time-scale ($5000\,$ d) 3D simulation of a common-envelope event with a $2\, {\rm M}_{\odot }$ red giant and a $1\, {\rm M}_{\odot }$ main-sequence companion, using the moving-mesh hydrodynamic solver manga. Starting with an orbital radius of $52\, \mathrm{ R}_{\odot }$, our binary shrinks to an orbital radius of $5\, \mathrm{ R}_{\odot }$ in $200\,$ d. We show that over a time-scale of about $1500\,$ d, the envelope is completely ejected, while 80 per cent is ejected in about $400\,$ d. The complete ejection of the envelope is solely powered by the orbital energy of the binary, without the need for late-time reheating from recombination or jets. Motivated by recent theoretical and observational results, we also find that the envelope enters a phase of homologous expansion about $550\, \rm d$ after the start of our simulation. We also run a simplified 1D model to show that heating from the central binary in the envelope at late times does not influence the ejection. This homologous expansion of the envelope would likely simplify calculations of the observational implications such as light curves.
Exceptional Early Jurassic fossils with leathery eggs shed light on dinosaur reproductive biology
Authors: Han Fenglu , Yu Yilun , Zhang Shukang , Zeng Rong , Wang Xinjin , Cai Huiyang , Wu Tianzhuang , Wen Yingfeng , Cai Sifu , Li Chun , Wu Rui , Zhao Qi , Xu Xing 
Published: October 2023

ABSTRACT
Our understanding of pre-Cretaceous dinosaur reproduction is hindered by a scarcity of evidence within fossil records. Here we report three adult skeletons and five clutches of embryo-containing eggs of a new sauropodomorph from the Lower Jurassic of southwestern China, displaying several significant reproductive features that are either unknown or unlike other early-diverging sauropodomorphs, such as relatively large eggs with a relatively thick calcareous shell formed by prominent mammillary cones, synchronous hatching and a transitional prehatching posture between the crocodilians and living birds. Most significantly, these Early Jurassic fossils provide strong evidence for the earliest known leathery eggs. Our comprehensive quantitative analyses demonstrate that the first dinosaur eggs were probably leathery, elliptical and relatively small, but with relatively long eggshell units, and that along the line to living birds, the most significant change in reptilian egg morphology occurred early in theropod evolution rather than near the origin of Aves.
Eggplant transcription factor SmMYB5 integrates jasmonate and light signaling during anthocyanin biosynthesis
Authors: Li Shaohang , Dong Yanxiao , Li Dalu , Shi Suli , Zhao Na , Liao Jielei , Liu Yang , Chen Huoying 
Published: October 2023

Abstract
Low light conditions severely suppress anthocyanin synthesis in fruit skins, leading to compromised fruit quality in eggplant (Solanum melongena L.) production. In this study, we found that exogenous methyl-jasmonate (MeJA) application can effectively rescue the poor coloration of the eggplant pericarp under low light conditions. However, the regulatory relationship between jasmonate and light signaling for regulating anthocyanin synthesis remains unclear. Here, we identified a JA response factor, SmMYB5, as an anthocyanin positive regulator by applying RNA-sequencing and characterization of transgenic plants. Firstly, we resolved that SmMYB5 can interact with TRANSPARENT TESTA8 (SmTT8), an anthocyanin-promoted BASIC HELIX-LOOP-HELIX (bHLH) transcription factor, to form the SmMYB5–SmTT8 complex and activate CHALCONE SYNTHASE (SmCHS), FLAVANONE-3-HYDROXYLASE (SmF3H), and ANTHOCYANIN SYNTHASE (SmANS) promoters by direct binding. Secondly, we revealed that JA signaling repressors JASMONATE ZIM DOMAIN5 (SmJAZ5) and SmJAZ10 can interfere with the stability and transcriptional activity of SmMYB5–SmTT8 by interacting with SmMYB5. JA can partially rescue the transcriptional activation of SmF3H and SmANS promoters by inducing SmJAZ5/10 degradation. Thirdly, we demonstrated that the protein abundance of SmMYB5 is regulated by light. CONSTITUTIVELY PHOTOMORPHOGENIC1 (SmCOP1) interacts with SmMYB5 to trigger SmMYB5 degradation via the 26S proteasome pathway. Finally, we delineated a light-dependent JA-SmMYB5 signaling pathway that promotes anthocyanin synthesis in eggplant fruit skins. These results provide insights into the mechanism of the integration of JA and light signals in regulating secondary metabolite synthesis in plants.
IbMYB73 targets abscisic acid-responsive IbGER5 to regulate root growth and stress tolerance in sweet potato
Authors: Wang Zhen , Li Xu , Gao Xiao-ru , Dai Zhuo-ru , Peng Kui , Jia Li-cong , Wu Yin-kui , Liu Qing-chang , Zhai Hong , Gao Shao-pei , Zhao Ning , He Shao-zhen , Zhang Huan 
Published: October 2023

Abstract
Root development influences plant responses to environmental conditions, and well-developed rooting enhances plant survival under abiotic stress. However, the molecular and genetic mechanisms underlying root development and abiotic stress tolerance in plants remain unclear. In this study, we identified the MYB transcription factor-encoding gene IbMYB73 by cDNA-amplified fragment length polymorphism and RNA-seq analyses. IbMYB73 expression was greatly suppressed under abiotic stress in the roots of the salt-tolerant sweet potato (Ipomoea batatas) line ND98, and its promoter activity in roots was significantly reduced by abscisic acid (ABA), NaCl, and mannitol treatments. Overexpression of IbMYB73 significantly inhibited adventitious root growth and abiotic stress tolerance, whereas IbMYB73-RNAi plants displayed the opposite pattern. IbMYB73 influenced the transcription of genes involved in the ABA pathway. Furthermore, IbMYB73 formed homodimers and activated the transcription of ABA-responsive protein IbGER5 by binding to an MYB binding sites I motif in its promoter. IbGER5 overexpression significantly inhibited adventitious root growth and abiotic stress tolerance concomitantly with a reduction in ABA content, while IbGER5-RNAi plants showed the opposite effect. Collectively, our results demonstrated that the IbMYB73-IbGER5 module regulates ABA-dependent adventitious root growth and abiotic stress tolerance in sweet potato, which provides candidate genes for the development of elite crop varieties with well-developed root-mediated abiotic stress tolerance.
Measuring Policy Diffusion in Federal Systems: The Case of Legalizing Cannabis in Canada under Time Constraints
Authors: Brie Evelyne , Huo Cynthia , Alcantara Christopher 
Published: October 2023

Abstract
Existing studies of policy diffusion rely on quantitative or qualitative methods depending on the number of cases and the policy at hand. Studies of diffusion in Canada, for instance, almost exclusively use qualitative techniques due to the limited number of subnational units. In this article, we explore whether machine learning techniques can complement qualitative approaches in these contexts. In 2015, the Canadian federal government decided to impose the legalization of cannabis and gave the provinces and territories a short time frame to develop and implement legislation. Previous qualitative research on this case found that within-province policy development was more salient than interprovincial diffusion. Using a plagiarism detection software, we find limited evidence of exact matches between provincial legislation, but a cosine score approach reveals significant similarities across provinces. These results suggest that computational and qualitative techniques together should be used where possible to identify and analyze policy diffusion in certain contexts.
Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function in the Ischemic Heart: A Redox-dependent Mechanism for AMPK Activation by Thioredoxin-1
Authors: Zhu Yi , He Ya-Jun , Yu Yuan , Xu Dan , Yuan Shi-Ying , Yan Hong 
Published: October 2023

Abstract:
Aldehyde dehydrogenase 2 (ALDH2) protects the ischemic heart by activating adenosine 5′-monophosphate-activated protein kinase (AMPK) signaling. However, the molecular mechanisms linking ALDH2 and AMPK signaling are not fully understood. This study aimed to explore the potential mechanisms linking ALDH2 and AMPK in myocardial ischemic injury. An ischemic model was established by ligating the left anterior descending coronary artery in rats. The overexpression or knockdown of ALDH2 in H9c2 cells treated with oxygen–glucose deprivation was obtained through lentivirus infection. Transferase-mediated dUTP nick-end labeling was used to evaluate apoptosis in an ischemic rat model and oxygen–glucose deprivation cells. ALDH2 activity, mitochondrial oxidative stress markers, adenosine triphosphate, respiratory control ratio, and cell viability in H9c2 cells were evaluated using a biological kit and 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide. Protein expression of ALDH2, 4-hydroxynonenal, thioredoxin-1 (Trx-1), and AMPK–proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) signaling pathway was detected through Western blotting. ALDH2 activation reduced ischemic-induced myocardial infarct size and apoptosis. ALDH2 protected mitochondrial function by enhancing mitochondrial respiratory control ratio and adenosine triphosphate production, alleviated mitochondrial oxidative stress, and suppressed myocardial apoptosis. Moreover, ALDH2 attenuated ischemia-induced oxidative stress and maintained Trx-1 levels by reducing 4-hydroxynonenal, thereby promoting AMPK–PGC-1α signaling activation. Inhibiting Trx-1 or AMPK abolished the cardioprotective effect of ALDH2 on ischemia. ALDH2 alleviates myocardial injury through increased mitochondrial biogenesis and reduced oxidative stress, and these effects were achieved through Trx1-mediating AMPK–PGC1-α signaling activation.
Experiences of fear of recurrence in patients with sarcoma
Authors: Vindrola-Padros Cecilia , Fern Lorna A. , Gerrand Craig , Hulbert-Williams Nicholas J. , Lawal Maria , Storey Lesley , Wells Mary , Windsor Rachael , Woodford Julie , Taylor Rachel M. 
Published: October 2023

Abstract

Background:
Fear of cancer recurrence (FCR) is often described as the most distressing consequence of cancer and has a negative impact on quality of life. There have been few investigations into the FCR in patients with sarcomas. We sought to explore the patient's FCR after a sarcoma diagnosis to determine when these fears were presented and the strategies patients used to address these fears.

Methods:
This was a secondary analysis of qualitative semi-structured interview data from patients with sarcoma, as part of a study to develop a patient-reported outcome measure. This study included 121 patients from across the United Kingdom aged 13–82 years. Telephone and face-to-face interviews focused on the experiences of living with and beyond a sarcoma diagnosis, based on the domains of quality of life (physical, emotional, and social well-being). A secondary analysis was performed using the Common-Sense Model.

Results:
The following four key themes were identified: triggers for FCR (symptoms and events), discussion of FCR, consequences of FCR (negative impact on quality of life), and strategies used to deal with FCR.

Conclusion:
Patients with sarcoma reported a FCR at different stages of treatment and how these fears played a role in their daily lives. Despite these experiences, the identification and management of FCR have not been reported as a core component of routine clinical practice.
Effect of Early Physical Therapy on Children of School Age With Hematological Cancer: A Quasi-Randomized Controlled Pilot Study
Authors: Sonoda Yuma , Tobita Ryo , Ikeda Yuhachi , Taga Takashi 
Published: October 2023

Purpose:
Although physical therapy (PT) positively impacts exercise capacity and health-related quality of life (HRQOL) in children with hematological cancers, the optimal time for intervention is unknown. We compared the effects of PT administered before and after initial cancer treatment on the exercise capacity and HRQOL of children with hematological cancer.

Methods:
The participants were allocated to early (before initiating treatment) and late PT (after initiating treatment) groups. We evaluated exercise capacity using the 6-min walking distance (6MWD) test and HRQOL using the Pediatric Quality of Life Inventory.

Results:
Thirteen school children (7-13 years) were included. The early PT cohort had significant improvements in Pediatric Quality of Life Inventory but not 6MWD scores from admission to the completion of initial treatment; however, both scores reduced significantly in the late PT cohort.

Conclusions:
Early rather than late PT during hospitalization might prevent reduced exercise capacity and improve HRQOL in children with hematological cancers.
Safety and Efficacy of a Third Dose of the BNT162b2 Vaccine in Liver-Transplanted and Healthy Adolescents
Authors: Sintusek Palittiya , Buranapraditkun Supranee , Khunsri Siriporn , Thongmee Thanunrat , Vichaiwattana Preeyaporn , Polsawat Warunee , Poovorawan Yong 
Published: October 2023

Objectives:
According to our previous study, the 2-dose-BNT162b2 vaccination is less effective against the Omicron variant. This study aimed to assess the safety and efficacy of a 3-dose-BNT162b2 vaccination in liver-transplanted (LT) and healthy adolescents.

Methods:
LT and healthy adolescents who met the inclusion criteria received a third dose of the BNT162b2 vaccine (30 µg). Antireceptor-binding domain immunoglobulin and T-cell-specific responses to severe acute respiratory syndrome coronavirus 2 spike peptides were assessed 3 months before the third dose (Visit −1) and 0 (Visit 0), 1 (Visit 1), and 2 months (Visit 2) after the third dose. Antinucleocapsid immunoglobulin and neutralizing antibodies were assessed at Visits 0 and 1. Adverse events (AEs) were monitored.

Results:
Eleven LT and 14 healthy adolescents aged 14.64 (13.2, 15.7) years (44.2% male) had antireceptor-binding domain immunoglobulin geometric mean titers of 1412.47 (95% confidence interval [CI], 948.18–2041.11) and 1235.79 (95% CI, 901.07–1705.73) U/mL at Visit −1 but increased to 38 587.76 (95% CI, 24 628.03–60 460.18) and 29 222.38 (95% CI, 16 291.72–52 401.03) U/mL (P < 0.05) at Visit 1, respectively. This was consistent with neutralizing antibodies (42.29% and 95.37% vs 44.65% and 91.68%, P < 0.001) and interferon-γ-secreting cells in LT and healthy adolescents at Visit 0 versus Visit 1, respectively. For serious AEs, an LT girl with autoimmune overlap syndrome died 5 months postvaccination from acute liver failure.

Conclusions:
In both LT and healthy adolescents, humoral and cellular immune responses were high after the 3-dose-BNT162b2 vaccination. However, serious AEs were suspected in LT adolescents with autoimmune diseases.