bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of divergent host use and geography in the evolution of habitat isolation and sexual isolation among sister species of Belonocnema gall wasps
Authors: Zhang Linyi , Hood Glen Ray , Ott James R , Egan Scott P 
Published: January 2024

Abstract
Ecology and geography can play important roles in the evolution of reproductive isolation across the speciation continuum, but few studies address both at the later stages of speciation. This notable gap in knowledge arises from the fact that traditional ecological speciation studies have predominantly focused on the role of ecology in initiating the speciation process, while many studies exploring the effect of geography (e.g., reinforcement) concentrate on species pairs that lack divergent ecological characteristics. We simultaneously examine the strength of habitat isolation and sexual isolation among three closely related species of Belonocnema gall-forming wasps on two species of live oaks, Quercus virginiana and Q. geminata, that experience divergent selection from their host plants and variable rates of migration due to their geographic context. We find that the strength of both habitat isolation and sexual isolation is lowest among allopatric species pairs with the same host plant association, followed by allopatric species with different host plant associations, and highest between sympatric species with different host-plant associations. This pattern suggests that divergent selection due to different host use interacts with geography in the evolution of habitat isolation and sexual isolation during the later stages of speciation of Belonocnema wasps.
An Economic Case against Public Banking, and a Case for It
Authors: Krishnamurthy Prasad , Cochenour Tucker 
Published: January 2024

Abstract
In this article, we examine the economics of public consumer banking in the United States. Public expenditures on consumer banking can take the form of price subsidies or direct provision. The economic case for price subsidies is weak because the evidence suggests most unbanked consumers would prefer a cash grant. The economic case for public provision is also weak because the existing market failures in banking are better remedied by regulation. The exceptions to this rule are check cashing and related payment services, which could be supplied by the US Postal Service (USPS) at a lower cost than private providers. On the other hand, economic arguments for the superiority of cash transfers presume that the institutional infrastructure exists to deliver them. But an effective infrastructure for public transfers does not exist in the United States and is only possible with universal ownership of payment accounts, which in turn requires some form of public subsidy or provision. We suggest one path forward: expand the financial services currently offered to federal beneficiaries—such as Social Security recipients—by the Treasury.
High-order azimuth coherent imaging for microseismic location
Authors: Shi Ying , Guo Xuebao , Yu Youqiang 
Published: January 2024

Abstract
The cross-correlation-based methods, widely used for microseismic monitoring, utilize cross-correlation to extract time differences of signals within station pairs, and subsequently use these time differences for back-projection and localization without the need for triggering moment scanning. The selection of imaging conditions, applied to the spatial projection of all cross-correlation records, determines the noise resistance and resolution of such methods. To fully exploit the azimuthal properties of station pairs for constraining the source imaging, we propose a high-order azimuth coherent imaging condition, which involves the following steps: (i) choosing station pairs that meet specific inter-station distance criteria; (ii) combining station pairs into dual-station pairs that satisfy a certain inter-station pair angle criterion; (iii) further combining station combinations pairwise to form the final set of station pairs; (iv) multiplying the projection results of station pairs within each combination from the third step; and (v) summing the results of all combinations. This method effectively suppresses the hyperboloid in the spatial projection of a single station, enhances the coherence of seismic source imaging, and maintains noise resistance. Compared to the conventional imaging conditions, the method proposed has demonstrated superior resolution and robustness in both theoretical analysis and practical testing.
Biomarkers for immune-related adverse events in cancer patients treated with immune checkpoint inhibitors
Authors: Liang Yao , Maeda Osamu , Ando Yuichi 
Published: January 2024

Abstract
Although immune checkpoint inhibitors have greatly improved cancer therapy, they also cause immune-related adverse events, including a wide range of inflammatory side effects resulting from excessive immune activation. Types of immune-related adverse events are diverse and can occur in almost any organ, with different frequencies and severities. Furthermore, immune-related adverse events may occur within the first few weeks after treatment or even several months after treatment discontinuation. Predictive biomarkers include blood cell counts and cell surface markers, serum proteins, autoantibodies, cytokines/chemokines, germline genetic variations and gene expression profiles, human leukocyte antigen genotype, microRNAs and the gut microbiome. Given the inconsistencies in research results and limited practical utility, there is to date no established biomarker that can be used in routine clinical practice, and additional investigations are essential to demonstrate efficacy and subsequently facilitate integration into routine clinical use.
Recent advances and future perspectives of T-cell engagers in lymphoid malignancies
Authors: Shirouchi Yuko , Maruyama Dai 
Published: January 2024

Abstract
Bispecific antibodies (BsAbs) are monoclonal antibodies that simultaneously bind to a specific antigen on tumors and CD3 on T cells, leading to T cell activation and subsequent tumor cell lysis. Several CD20 × CD3 BsAbs are being developed for B-cell lymphomas. Furthermore, multiple clinical trials to evaluate BsAbs for the treatment of multiple myeloma, with targets including BCMA, GPRC5D and FcRH5, are ongoing. Emerging evidence suggests promising efficacy in heavily pretreated patients with relapsed or refractory lymphoid malignancies, showing an overall response rate of 50–60%, with complete response rates of 30–40% for relapsed or refractory large B-cell lymphoma and 60–70% for relapsed or refractory multiple myeloma. Their toxicity profiles are generally consistent with other T-cell redirecting therapies, including cytokine release syndrome, which may be mitigated with several strategies, such as step-up dosing, pre-mediation with glucocorticoids and a subcutaneous route of administration, and very rare neurotoxicity. Several clinical trials evaluated BsAbs in combination with other agents or in earlier lines of treatment, including in front-line settings. BsAbs have the potential to change the treatment paradigm of lymphoid malignancies in the coming years; however, longer follow-ups are required to assess the durability of responses to these agents. We herein provide an overview of the findings of recent clinical trials on BsAbs, including mechanisms of action, safety profiles, and efficacy, and discuss the role of BsAbs in the treatment of B-cell lymphomas and multiple myeloma.
Si-Zhi Wan regulates osteoclast autophagy in osteoporosis through the AMPK signaling pathway to attenuate osteoclastogenesis
Authors: Huang Yucheng , Yao Huan , Tjahjono Adi Wirawan , Xiang Li , Li Ke , Tang Jiahe , Gao Yongxiang 
Published: January 2024

Abstract

Objectives
The mechanisms underlying the therapeutic effects of Si-Zhi Wan (SZW), a traditional Chinese medicine used to treat osteoporosis (OP), remain unknown. This study investigated the therapeutic effects of SZW on mice that underwent ovariectomy (OVX) and underlying mechanisms thereof.

Methods
We established an in vivo model of OP by performing OVX in mice. Microcomputed tomography (Micro-CT) was used to assess changes in bone characteristics of mice following SZW administration for 4 weeks. H&E staining revealed alterations in bone tissues of mice. Osteoclastogenesis in mouse bone tissue was observed using tartrate-resistant acid phosphatase staining and western blotting. Furthermore, we examined the impact of SZW on osteoclastogenesis in vitro using receptor activator of nuclear factor kappa-B ligand (RANKL). Finally, we explored the regulatory effects of SZW on osteoclast autophagy and the AMPK pathway.

Key findings
The results demonstrated that high-dose SZW reversed changes in bone density parameters caused by OVX, including bone volume (BV), BV/total volume, trabecular number, and trabecular spacing (P = 0.0007, 0.0035, 0.0114, and 0.0182, respectively), and stimulated the formation of bone trabeculae in mice (P &lt; 0.0001). Furthermore, SZW suppressed osteoclast formation in mice with OVX and inhibited osteoclast formation induced by RANKL. Mechanistically, SZW inhibited osteoclast precursor cell autophagy through the AMPK pathway.

Conclusions
SZW effectively inhibited the autophagy of osteoclast precursors by regulating the AMPK pathway, thereby exerting anti-osteoclastogenic effects and serving as an alternative therapy for OP.
Globular clusters and bar: captured or not captured?
Authors: Smirnov Anton A , Bajkova Anisa T , Bobylev Vadim V 
Published: January 2024

ABSTRACT
Studies of the dynamics of globular clusters assume different values of bar parameters (mass, velocity, and size) and analyse the results of orbit classifications over the range of the chosen values. It is also a usual thing that a spherical bulge component is converted into the bar to obtain a non-axisymmetric potential from an axisymmetric one. The choice of bar parameters and the way the bar is converted from the bulge introduce systematics into the orbit classifications that we explore in this study. We integrate orbits of 30 bulge globular clusters residing in the inner area of the Galaxy (R ≲ 5 kpc) backwards in time for three different potentials, two of which are obtained by fitting the rotation curve, and one is taken from the surrogate N-body model representing our Galaxy. We analyse each orbit in terms of dominant frequencies obtained from its coordinate spectra. We find that the bar pattern speed is a key factor in orbital classification. With an increase of the bar pattern speed, frequencies deviate more and more from the ‘bar’ frequency ratio 2:1. The bar-to-bulge mass ratio (assuming the total mass of the bar plus the bulge is fixed) and size of the bar play a smaller role. We also find that, in the N-body potential, the fraction of orbits that follow the bar is higher than in those obtained from fitting the rotation curve.
The dynamic centres of infrared-dark clouds and the formation of cores
Authors: Rigby Andrew J , Peretto Nicolas , Anderson Michael , Ragan Sarah E , Priestley Felix D , Fuller Gary A , Thompson Mark A , Traficante Alessio , Watkins Elizabeth J , Williams Gwenllian M 
Published: January 2024

ABSTRACT
High-mass stars have an enormous influence on the evolution of the interstellar medium in galaxies, so it is important that we understand how they form. We examine the central clumps within a sample of seven infrared-dark clouds (IRDCs) with a range of masses and morphologies. We use 1-pc-scale observations from the Northern Extended Millimeter Array (NOEMA) and the IRAM 30m telescope to trace dense cores with 2.8-mm continuum, and gas kinematics in C18O, HCO+, HNC, and N2H+ (J = 1–0). We supplement our continuum sample with six IRDCs observed at 2.9 mm with the Atacama Large Millimeter/submillimeter Array (ALMA), and examine the relationships between core- and clump-scale properties. We have developed a fully automated multiple-velocity component hyperfine line-fitting code called mwydyn which we employ to trace the dense gas kinematics in N2H+ (1–0), revealing highly complex and dynamic clump interiors. We find that parsec-scale clump mass is the most important factor driving the evolution; more massive clumps are able to concentrate more mass into their most massive cores – with a log-normally distributed efficiency of around 9 per cent – in addition to containing the most dynamic gas. Distributions of linewidths within the most massive cores are similar to the ambient gas, suggesting that they are not dynamically decoupled, but are similarly chaotic. A number of studies have previously suggested that clumps are globally collapsing; in such a scenario, the observed kinematics of clump centres would be the direct result of gravity-driven mass inflows that become ever more complex as the clumps evolve, which in turn leads to the chaotic mass growth of their core populations.
An analytic surface density profile for ΛCDM haloes and gravitational lensing studies
Authors: Lazar Alexandres , Bullock James S , Nierenberg Anna , Moustakas Leonidas A , Boylan-Kolchin Michael 
Published: January 2024

ABSTRACT
We introduce an analytic surface density profile for dark matter haloes that accurately reproduces the structure of simulated haloes of mass Mvir = 107–1011 M⊙, making it useful for modelling line-of-sight (LOS) perturbers in strong gravitational lensing models. The two-parameter function has an analytic deflection potential and is more accurate than the projected Navarro, Frenk, and White profile commonly adopted at this mass scale for perturbers, especially at the small radii of most relevant for lensing perturbations. Using a characteristic radius, R−1, where the log slope of surface density is equal to −1, and an associated surface density, Σ−1, we can represent the expected lensing signal from LOS haloes statistically, for an ensemble of halo orientations, using a distribution of projected concentration parameters, $\mathcal {C}_{\rm vir} := r_{\rm vir}/ R_{-1}$. Though an individual halo can have a projected concentration that varies with orientation with respect to the observer, the range of projected concentrations correlates with the usual three-dimensional halo concentration in a way that enables ease of use.
Antiproliferative activity of platinum(II) and copper(II) complexes containing novel biquinoxaline ligands
Authors: El-Beshti Hager Sadek , Gercek Zuhal , Kayi Hakan , Yildizhan Yasemin , Cetin Yuksel , Adigüzel Zelal , Güngör Gamze , Özalp-Yaman Şeniz 
Published: January 2024

Abstract
Nowadays, cancer represents one of the major causes of death in humans worldwide, which renders the quest for new and improved antineoplastic agents to become an urgent issue in the field of biomedicine and human health. The present research focuses on the synthesis of 2,3,2ʹ,3ʹ-tetra(pyridin-2-yl)-6,6ʹ-biquinoxaline) and (2,3,2ʹ,3ʹ-tetra(thiophen-2-yl)-6,6ʹ-biquinoxaline) containing copper(II) and platinum(II) compounds as prodrug candidates. The binding interaction of these compounds with calf thymus DNA (CT-DNA) and human serum albumin were assessed with UV titration, thermal decomposition, viscometric, and fluorometric methods. The thermodynamical parameters and the temperature-dependent binding constant (Kʹb) values point out to spontaneous interactions between the complexes and CT-DNA via the van der Waals interactions and/or hydrogen bonding, except Cu(ttbq)Cl2 for which electrostatic interaction was proposed. The antitumor activity of the complexes against several human glioblastomata, lung, breast, cervix, and prostate cell lines were investigated by examining cell viability, oxidative stress, apoptosis-terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, in vitro migration and invasion, in vitro-comet DNA damage, and plasmid DNA interaction assays. The U87 and HeLa cells were investigated as the cancer cells most sensitive to our complexes. The exerted cytotoxic effect of complexes was attributed to the formation of the reactive oxygen species in vitro. It is clearly demonstrated that Cu(ttbq)Cl2, Pt(ttbq)Cl2, and Pt(tpbq)Cl2 have the highest DNA degradation potential and anticancer effect among the tested complexes by leading apoptosis. The wound healing and invasion analysis results also supported the higher anticancer activity of these two compounds.
A probe into the acid deposition mitigation path in China over the last four decades and beyond
Authors: Yu Qian , Ge Xiaodong , Zheng Haotian , Xing Jia , Duan Lei , Lv Dongwei , Ding Dian , Dong Zhaoxin , Sun Yisheng , Maximilian Posch , Xie Danni , Zhao Yu , Zhao Bin , Wang Shuxiao , Mulder Jan , Larssen Thorjørn , Hao Jiming 
Published: January 2024

ABSTRACT
China currently has the highest acid deposition globally, yet research on its status, impacts, causes and controls is lacking. Here, we compiled data and calculated critical loads regarding acid deposition. The results showed that the abatement measures in China have achieved a sharp decline in the emissions of acidifying pollutants and a continuous recovery of precipitation pH, despite the drastic growth in the economy and energy consumption. However, the risk of ecological acidification and eutrophication showed no significant decrease. With similar emission reductions, the decline in areas at risk of acidification in China (7.0%) lags behind those in Europe (20%) or the USA (15%). This was because, unlike Europe and the USA, China's abatement strategies primarily target air quality improvement rather than mitigating ecological impacts. Given that the area with the risk of eutrophication induced by nitrogen deposition remained at 13% of the country even under the scenario of achieving the dual targets of air quality and carbon dioxide mitigation in 2035, we explored an enhanced ammonia abatement pathway. With a further 27% reduction in ammonia by 2035, China could largely eliminate the impacts of acid deposition. This research serves as a valuable reference for China's future acid deposition control and for other nations facing similar challenges.
New structure transistors for advanced technology node CMOS ICs
Authors: Zhang Qingzhu , Zhang Yongkui , Luo Yanna , Yin Huaxiang 
Published: January 2024

ABSTRACT
Over recent decades, advancements in complementary metal-oxide-semiconductor integrated circuits (ICs) have mainly relied on structural innovations in transistors. From planar transistors to the fin field-effect transistor (FinFET) and gate-all-around FET (GAAFET), more gate electrodes have been added to three-dimensional (3D) channels with enhanced control and carrier conductance to provide higher electrostatic integrity and higher operating currents within the same device footprint. Beyond the 1-nm node, Moore’s law scaling is no longer expected to be applicable to geometrical shrinkage. Vertical transistor stacking, e.g. in complementary FETs (CFET), 3D stack (3DS) FETs and vertical-channel transistors (VFET), for enhanced density and variable circuit or system design represents a revolutionary scaling approach for sustained IC development. Herein, innovative works on specific structures, key process breakthroughs, shrinking cell sizes and design methodologies for transistor structure research and development are reviewed. Perspectives on future innovations in advanced transistors with new channel materials and operating theories are also discussed.
The application of machine learning on brain imaging features of different narcolepsy subtypes
Authors: Chin Wei-Chih , Huang Sheng-Yao , Liu Feng-Yuan , Wang Chih-Huan , Tang I , Hsiao Ing-Tsung , Huang Yu-Shu 
Published: January 2024

AbstractStudy ObjectivesNarcolepsy is a central hypersomnia disorder, and differential diagnoses between its subtypes can be difficult. Hence, we applied machine learning to analyze the positron emission tomography (PET) data of patients with type 1 or type 2 narcolepsy, and patients with type 1 narcolepsy and comorbid schizophrenia, to construct predictive models to facilitate the diagnosis.MethodsThis is a retrospective and prospective case–control study of adolescent and young adult patients with type 1 or type 2 narcolepsy, and type 1 narcolepsy and comorbid schizophrenia. All participants received 18-F-fluorodeoxy glucose PET, sleep studies, neurocognitive tests, sleep questionnaires, and human leukocyte antigen typing. The collected PET data were analyzed by feature selections and classification methods in machine learning to construct predictive models.ResultsA total of 314 participants with narcolepsy were enrolled; 204 had type 1 narcolepsy, 90 had type 2 narcolepsy, and 20 had type 1 narcolepsy and comorbid schizophrenia. We used three filter methods for feature selection followed by a comparative analysis of classification methods. To apply a small number of regions of interest (ROI) and high classification accuracy, the Naïve Bayes classifier with the Term Variance as feature selection achieved the goal with only three ROIs (left basal ganglia, left Heschl, and left striatum) and produced an accuracy of higher than 99%.ConclusionsThe accuracy of our predictive model of PET data are promising and can aid clinicians in the diagnosis of narcolepsy subtypes. Future research with a larger sample size could further refine the predictive model of narcolepsy.
Genome-wide support for incipient Tula hantavirus species within a single rodent host lineage
Authors: Labutin Anton , Heckel Gerald 
Published: January 2024

Abstract
Evolutionary divergence of viruses is most commonly driven by co-divergence with their hosts or through isolation of transmission after host shifts. It remains mostly unknown, however, whether divergent phylogenetic clades within named virus species represent functionally equivalent byproducts of high evolutionary rates or rather incipient virus species. Here, we test these alternatives with genomic data from two widespread phylogenetic clades in Tula orthohantavirus (TULV) within a single evolutionary lineage of their natural rodent host, the common vole Microtus arvalis. We examined voles from forty-two locations in the contact region between clades for TULV infection by reverse transcription (RT)-PCR. Sequencing yielded twenty-three TULV Central North and twenty-one TULV Central South genomes, which differed by 14.9–18.5 per cent at the nucleotide and 2.2–3.7 per cent at the amino acid (AA) level without evidence of recombination or reassortment between clades. Geographic cline analyses demonstrated an abrupt (&lt;1 km wide) transition between the parapatric TULV clades in continuous landscape. This transition was located within the Central mitochondrial lineage of M. arvalis, and genomic single nucleotide polymorphisms showed gradual mixing of host populations across it. Genomic differentiation of hosts was much weaker across the TULV Central North to South transition than across the nearby hybrid zone between two evolutionary lineages in the host. We suggest that these parapatric TULV clades represent functionally distinct, incipient species, which are likely differently affected by genetic polymorphisms in the host. This highlights the potential of natural viral contact zones as systems for investigating the genetic and evolutionary factors enabling or restricting the transmission of RNA viruses.