bluuebunny/crossref_metadata_2025_split huggingface dataset:
What are family caregivers’ experiences of coordinating end-of-life care at home? A narrative review
Authors: Nicholls Harriet , Carey Matthew , Hambridge Kevin 
Published: January 2025

Abstract

Objectives
People with life-limiting diseases, who are no longer receiving active or curable treatment, often state their preferred place of care and death as the home. This requires coordinating a multidisciplinary approach, using available health and social care services to synchronize care. Family caregivers are key to enabling home-based end-of-life support; however, the 2 elements that facilitate success – coordination and family caregiver – are not necessarily associated as being intertwined or one and the same. This narrative review explores family caregiver experiences of coordinating end-of-life care in the home setting.

Methods
Studies were identified systematically following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A search of 5 databases (CINAHL, AMED, MEDLINE, Joanna Briggs Institute for Systematic Reviews, and the Cochrane Database) was conducted using Medical Subject Headings search terms and Boolean operators. Seven hundred and eighty papers were screened. Quality assessment was conducted using the JBI Critical Appraisal Checklist for Qualitative Research. Characteristics of included studies were extracted using the Joanna Briggs Institute Qualitative Assessment and Review Instrument (JBI-QARI) extraction tool.

Results
Ten qualitative studies were included. A meta-aggregative approach was used to assemble findings and categories extracted from the included papers, which led to identification of 3 overall themes: (1) family caregiver identity, (2) strategies for care, and (3) practicalities of care.

Significance of results
Research suggests there should be a designated care coordinator to support people nearing the end of life at home. However, this review shows that family caregivers intrinsically take on this role. Their experiences, frequently share commonalities across different cultures and regions, highlighting the universal nature of their challenges. Difficulties associated with providing home-based care are evident, but the undertaking of care coordination by relatives highlights a need for a change in approach. Future studies could explore the impact of having a designated “facilitator” or single point of contact for families, as well as the development of tailored communication strategies.
Globalization and religious resurgence: a comparative analysis
Authors: Szendrő Brendan 
Published: January 2025

Abstract
Why does religion continue to emerge as a flashpoint in the age of secularization? Although models of religious resurgence suggest that religious cleavages are more prominent in the modern era, other models continue to show declining religious involvement. What is needed is a theory that can observe both resurgence and secularization at the same time. I argue that globalization—and the flow of people across borders, in particular—provokes a religious backlash at the societal level due to its secularizing effects. As the public is exposed to new and diverse religious traditions, religiosity declines; as a result, however, religious practitioners become more aggressive toward other religious groups. I test this theory using data on globalization, religious discrimination, and religious practice. I find that types of globalization dealing with the flow of people and information across borders have an outsize effect on societal religious discrimination, or SRD. This effect, however, is contingent on a decline in religious practice. This study suggests that religious resurgence can take place in secularizing environments, and that both resurgence and secularization share root causes.
Perceived threat and demographic misperception
Authors: Ives Brandon , Breslawski Jori 
Published: January 2025

Abstract
What causes demographic misperceptions of minority populations? We anticipate that the extent to which members of the majority group perceive the minority group as a threat shapes their estimation of minority group size. While existing research argues that demographic misperceptions of minority groups can lead to a sense of threat, we argue that the opposite relationship may exist—that threat also causes demographic misperception. We test our argument using an experiment embedded in a survey of Muslims in Indonesia. We manipulate perceived threat of Christians in Indonesia and then ask respondents to estimate the size of the Christian population. While Muslims generally overestimated the size of the Christian population, we find that Muslims who felt a greater sense of threat estimated the Christian population to be significantly larger at both the national and provincial levels. This finding provides new insights on the directionality of the relationship between the widely acknowledged connection between threat and demographic misperceptions.
Evolution of Shoulder Type Escarpments Through Feedback Between Knickpoint and Windgap Migration
Authors: Qu Tianyue , Shelef Eitan , Goren Liran , Harel Elhanan , Porat Omri 
Published: January 2025

AbstractEscarpments and cliffs (hereafter termed escarpments) form topographic barriers that influence the spatial patterns of climate and biodiversity. The inherent extreme slope change across the escarpment edge promotes escarpment retreat over time. Typically, escarpments are divided into arch‐ and shoulder‐types. In arch‐type, the drainage divide is located inland, and knickpoints, located where channels flow across the escarpment, can retreat and embay the escarpment. In shoulder‐type, the divide aligns with the escarpment edge, a setting expected to cause a slow and uniform escarpment retreat, preserving their integrity as barriers through time. However, observations from around the globe reveal shoulder‐type escarpments are associated with deep embayments (i.e., alcoves) that destroy the linear appearance of the escarpment front. Yet, the processes that produce and sustain these embayments remain largely unexplored. Embayments of shoulder‐type escarpments typically occur along reversed channels which were part of the antecedent drainage that used to flow away from the escarpment but now flow toward it, often resulting in a valley confined drainage divide called a windgap. Here, we hypothesize that feedback between knickpoint retreat and windgap migration away from the escarpment along reversed channels can sustain escarpment embayments, and use topographic analyses and numerical simulations to explore this hypothesis. Our analyses, focused on field sites in the Negev Desert, show that embayments of shoulder‐type escarpments can be sustained through the hypothesized feedback, and quantify the sensitivity of this feedback to geomorphologic and lithologic parameters. Results suggest that this feedback may explain some of the global variability of escarpment morphologies.
Consecutive Glacier Sub‐Surge Events Within Five Years Were Identified in an Unexplored Glacier of the Karakoram
Authors: Zhu Q. H. , Li H. L. , Ke C. Q. 
Published: January 2025

AbstractIn order to monitor the dynamic changes of an unnamed glacier (called G1 Glacier) located in the Karakoram in detail, glacier surface velocities were extracted from 165 Sentinel‐1 SAR images with 12‐day and 24‐day time intervals from 2014 to 2020, glacier elevation changes were obtained from four ASTER stereo images, and glacier terminus evolutions were derived from four Landsat 8 images. Based on the high‐density glacier surface velocity results, four consecutive glacier sub‐surge events of the G1 Glacier ranging from 6 months to 1 yr between 2015 and 2019 were confirmed for the first time, accompanied by sporadic pulse events before and after the four sub‐surges. The velocity changes and impact range of the four glacier sub‐surges showed a trend of first increasing, then stabilizing and finally decreasing. At the same time, the accelerating area gradually moved downstream of the glacier. The changes in glacier elevation and the evolutions in the glacier terminus also proved the occurrence of glacier acceleration events. Sentinel‐1 SAR images with shorter time intervals could be used to identify multiple sub‐surge events and pulse events within a complete surge. Combining four sub‐surges and multiple pulse events, a complete chain of glacier large‐scale acceleration events from pulse to surge and then to pulse could be summarized, which might mean that the effective identification of pulse events provides the possibility for the early warning of glacier surge events.
Transparent OLED displays for selective bidirectional viewing using ZnO/Yb:Ag cathode with highly smooth and low-barrier surface
Authors: Choi Eun-young , Kang Sung-Cheon , Kim Kanghoon , Lee Su-Hyeon , Kim Jeong-Beom , Song Jang-Kun 
Published: January 2025

Abstract
Transparent organic light-emitting diode (TrOLED) displays represent cutting-edge technology posed to significantly enhance user experience. This study addresses two pivotal challenges in TrOLED development. Firstly, we focus on the innovation of transparent cathodes, a fundamental component in TrOLEDs, by introducing a ZnO/Yb:Ag cathode. This cathode employs a combination of seed layer and metal doping techniques to achieve a highly uniform surface morphology and a low surface energy barrier. The optimized Yb:Ag cathode on ZnO, with a mere thickness of 15 nm, exhibits remarkable properties: an extremely low surface roughness of 0.52 nm, sheet resistance of 11.6 Ω ϒ−1, an optical transmittance of 86.7% at 510 nm, and tunable work function (here, optimized to be 3.86 eV), ensuring superior electron injection capability. Secondly, we propose a novel TrOLED pixel structure that features selective bidirectional viewing, allowing different types of information to be selectively displayed on each side while preserving overall transparency and minimizing pixel complexity. This design innovation distinguishes itself from conventional TrOLEDs that display images on only one side. The bidirectional TrOLED design not only enhances openness and esthetic appeal but also holds promise for diverse applications across various user environments.
Deficiency of the palmitoyl acyltransferase ZDHHC7 modulates depression-like behaviour in female mice after a mild chronic stress paradigm
Authors: Hohoff Christa , Kerkenberg Nicole , Zhang Mingyue , Palkowska Weronika , Wachsmuth Lydia , Peng Maja , Stiehl Lena , Schettler Christiane , Zang Johannes C. S. , Huge Andreas , Ponimaskin Evgeni , Faber Cornelius , Baune Bernhard T. , Zhang Weiqi 
Published: January 2025

Abstract
Chronic stress (CS) is a debilitating condition that negatively affects body and brain. In mice, CS effects range from changes in behaviour and brain microstructure down to the level of gene expression. These effects are partly mediated by sex and sex steroid hormones, which in turn are affected by the palmitoyl acyltransferase ZDHHC7. ZDHHC7 might modulate also the response to CS via palmitoylation of sex steroid hormone receptors and other proteins critical for neuronal structure and functions. Therefore, we aimed to investigate the role of ZDHHC7 in response to CS on different system levels in a mouse model of Zdhhc7-deficiency. Female and male Zdhhc7-knockout (KO) and -wildtype (WT) mice underwent a four-week-mild CS paradigm or non-stress control (C) condition. After C or CS, behaviours, hippocampal microstructures (via MRI-based diffusion tensor imaging) and brain gene expression profiles (via mRNA-seq transcriptomics) were investigated. Analyses focused on effects of genotype (KO vs. WT) or condition (C vs. CS) separately in both sexes. Our results revealed significant effects particularly in females. Female KOs displayed increased locomotion and reduced depression-like behaviour after CS (KO vs. WT, C vs. CS: p

all
< 0.05). Hippocampal fibres were reduced in female KOs after C (KO vs. WT: p

all
< 0.05) but in female WTs after CS (C vs. CS: p

all
< 0.05). Furthermore, female KOs showed increased cortistatin expression after CS (C vs. CS: mRNAseq and qPCR p

all
< 0.05). In sum, Zdhhc7-deficiency reduced depression-like behaviours, prevented hippocampal fibre reduction and upregulated cortistatin after CS. It seemed to be related to a sex-specific stress response and may reveal genetic factors of CS-resilience in female mice.
Optimising deep learning models for ophthalmological disorder classification
Authors: Vidivelli S. , Padmakumari P. , Parthiban C. , DharunBalaji A. , Manikandan R. , Gandomi Amir H. 
Published: January 2025

Abstract
Fundus imaging, a technique for recording retinal structural components and anomalies, is essential for observing and identifying ophthalmological diseases. Disorders such as hypertension, glaucoma, and diabetic retinopathy are indicated by structural alterations in the optic disc, blood vessels, fovea, and macula. Patients frequently deal with various ophthalmological conditions in either one or both eyes. In this article, we have used different deep learning models for the categorisation of ophthalmological disorders into multiple classes and multiple labels utilising transfer learning-based convolutional neural network (CNN) methods. The Ocular Disease Intelligent Recognition (ODIR) database is used for experiments, and it contains fundus images of the patient’s left and right eyes. We compared the performance of two different optimisers, Stochastic Gradient Descent (SGD) and Adam, separately. The best result was achieved using the MobileNet model with the Adam optimiser, yielding a testing accuracy of 89.64%.
Sex-specific association of immunological markers in CS-delivered newborns with pre-pregnancy body mass index and gestational weight gain of mothers
Authors: Rak Karolina , Godyla-Jabłoński Michaela , Bronkowska Monika 
Published: January 2025

Abstract
Just as overweight and obesity may impair immunity, excessive body weight-related parameters of women in the pre-conception period and during pregnancy are possible detrimental factors for fetal programming of the immune system in their offspring. We investigated the relationship of pre-pregnancy body mass index (pBMI) and gestational weight gain (GWG) of mothers with the placental transport rate (PTR) of IgG antibodies and antineutrophil cytoplasmatic antibodies against lactoferrin (Lf-ANCA) and their concentration in umbilical cord blood serum (UCS), verifying the sex-specificity of this relationship. The examined group of this cross-sectional pilot study consisted of 101 pregnant women and their healthy CS-delivered newborn children. The concentration of antibodies in maternal serum (MS) and UCS were determined by ELISA method. PTR was assessed as a ratio of the concentration of antibodies in the UCS and MS. A significantly lower PTR of IgG and their concentration in the UCS were demonstrated in newborns of mothers with an excessive pBMI compared to those with pBMI < 25 and the association was more pronounced in male newborns. The lowest PTR of beneficial IgG and their concentration in the UCS as well as the highest PTR of detrimental Lf-ANCA and their concentration in UCS were observed in newborns born to mothers with co-occurrence of both an excessive pBMI and GWG. It seems that maternal preconception overweight and obesity along with an excessive GWG can be a predictor of unfavorable immune effects in fetuses. Further studies are needed to explain the role of maternal weight-related parameters in the development of immunological health of their offspring.
Giant pit craters on the modern seafloor above magma-induced hydrothermal vent complexes of Scotia Sea, offshore Antarctica
Authors: Somoza L. , Andreassen K. M. , Plaza-Faverola A. , Medialdea T. , Gafeira J. , González F. J. , Dickens G. R. 
Published: January 2025

Abstract
Massive injection of 13C depleted carbon to the ocean and atmosphere coincided with major environmental upheaval multiple times in the geological record. For several events, the source of carbon has been attributed to explosive venting of gas produced when magmatic sills intruded organic-rich sediment. The concept mostly derives from studies of a few ancient sedimentary basins with numerous hydrothermal vent complexes (HTVCs) where craters appear to have formed across large areas of the seafloor at the same time, but good examples remain rare in strata younger than the Early Eocene. We present geophysical data documenting at least 150 large (km-scale) craters on the modern seafloor across ∼148,000 km2 of Scan Basin in the southern Scotia Sea, a remote region offshore Antarctica. Seismic and bathymetric information reveals the craters relate to vertical fluid pipes extending above dome-shaped forced folds and saucer-shaped igneous sills. Presumably, magmatic intrusions deform overlying sediment and produce thermogenic gas, where buoyant hydrothermal fluids migrate upwards from sill flanks through V-shaped gas chimneys to the seafloor. Fluid expulsion, driven by excess pore pressure, enhances vertical conduits and creates collapse structures on the seafloor. Age estimates for sill emplacement and crater formation come from correlations of seismic reflectors with bore hole data collected on IODP Expedition 382. Sills intruded into sediment at least two times, first about 12–13 Ma (Middle Miocene), which occurred with deep intrusions of stacked composite sills, and once about 0.9 Ma and associated with volcanism along Discovery Bank, which may have reactivated previous fluid venting. Crater reactivation has occurred since 0.9 Ma, although probably episodically. Importantly, at present-day, numerous craters related to sills and fluid pipes populate the seafloor above a young sedimentary basin, and the ocean and atmosphere are receiving massive quantities of 13C depleted carbon. The two phenomena are unrelated but, with changes in global climate and sedimentation, the craters could be filled simultaneously and give an impression in the rock record of rapid and coeval formation coincident with carbon emission. Interpretations of ancient HTVCs and their significance to global carbon cycling needs revision with consideration of modern seafloor regions with HTVCs, notably Scan Basin.
Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events
Authors: Chen Li , Pruteanu-Malinici Iulian , Dastur Anahita , Yin Xunqin , Frederick Dennie , Sadreyev Ruslan I. , Benes Cyril H. 
Published: January 2025

Abstract
Genotype-informed anticancer therapies such as BRAF inhibitors can show remarkable clinical efficacy in BRAF-mutant melanoma; however, drug resistance poses a major hurdle to successful cancer treatment. Many resistance events to targeted therapies have been identified, suggesting a complex path to improve therapeutics. Here, we showed the utility of a piggyBac transposon activation mutagenesis screen for the efficient identification of genes that are resistant to BRAF inhibition in melanoma. Although several forward genetic screens performed in the same context have identified a broad range of resistance genes that poorly overlap, an integrative analysis revealed a much smaller functional diversity of resistance mechanisms, including reactivation of the MAPK pathway, PI3K-AKT pathway, and Hippo pathway, suggesting that a relatively small number of therapeutic strategies might overcome resistance manifested by a large gene set. Moreover, we illustrated the pivotal role of the Hippo pathway effector TAZ (encoded by the WWTR1 gene) in mediating BRAF inhibition resistance through transcriptional regulation of receptor tyrosine kinases and through interactions with the E3 ubiquitin ligase NEDD4L.
A phylogenetic epidemiology approach to predicting the establishment of multi-host plant pests
Authors: Lynch Shannon Colleen , Reyes-Gonzalez Edeli , Bossard Emily L. , Alarcon Karen S. , Love Natalie L. R. , Hollander Allan D. , Nobua-Behrmann Beatriz E. , Gilbert Gregory S. 
Published: January 2025

Abstract
Forecasting emergent pest spread is paramount to mitigating their impacts. For host-specialized pests, epidemiological models of spread through a single host population are well developed. However, most pests attack multiple host species; the challenge is predicting which communities are most vulnerable to infestation. Here, we develop a phylogenetically-informed approach to predict establishment of emergent multi-host pests across heterogeneous landscapes. We model a beetle-pathogen symbiotic complex on trees, introduced from Southeast Asia to California. The phyloEpi model for likelihood of establishment was predicted from the phylogenetic composition of woody species in the invaded community and the influence of temperature on beetle reproduction. Plant communities dominated by close relatives of known epidemiologically critical hosts were four times more likely to become infested than communities with more distantly related species. Where microclimate favored beetle reproduction, pest establishment was greater than expected based only on species composition. We applied this phyloEpi model to predict infestation risk in California using weather data and complete tree inventories from 9262 1-km2 grids in 170 cities. Regions in the state predicted with low likelihood of infestation were confirmed by independent monitoring. Analysts can adapt these phylogenetic ecology tools to predict spread of any multi-host pest in novel habitats.
Landslide-channel feedbacks amplify channel widening during floods
Authors: Bennett Georgina L. , Panici Diego , Rengers Francis K. , Kean Jason W. , Rathburn Sara L. 
Published: January 2025

Abstract
Channel widening is a major hazard during floods, particularly in confined mountainous catchments. However, channel widening during floods is not well understood and not always explained by hydraulic variables alone. Floods in mountainous regions often coincide with landslides triggered by heavy rainfall, yet landslide-channel interactions during a flood event are not well known or documented. Here we demonstrate with an example from the Great Colorado Flood in 2013, a 1000 year precipitation event, how landslide-channel feedbacks can substantially amplify channel widening and flood risk. We use a combination of DEM differencing, field analysis, and multiphase flow modeling to document landslide-channel interaction during the flood event in which sediment delivered by landslides temporarily dammed the channel before failing and generating substantial channel widening. We propose that such landslide-flood interactions will become increasingly important to account for in flood hazard assessment as flooding and landsliding both increase with extreme rainfall under climate change.