bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of dual-energy computed tomography in the diagnosis of neurological complications after endovascular treatment of acute ischaemic stroke: a systematic review and meta-analysis
Authors: Ebaid Noha Yahia , Mouffokes Adel , Yasen Noha S , Elrosasy Amr M , Philip Kerollos George , Assy Mostafa Mohamad , Alsowey Ahmed Mohamed 
Published: January 2024

Abstract

Objectives
To investigate dual-energy computed tomography’s (DECT) diagnostic performance in detecting neurological complications following endovascular therapy (EVT) of acute ischaemic stroke (AIS).

Methods
We performed the literature search using Web of Science, Scopus, PubMed, EBSCO, and Science Direct databases for published related studies. The selected studies estimated the validity of DECT in the detection of neurological complications after EVT for AIS. Study quality assessment was performed utilizing the Quality of Diagnostic Accuracy Studies-2 Tool. Our meta-analysis calculated the pooled sensitivity, negative likelihood ratio, specificity, and positive likelihood ratio for each detected complication. The summary receiver operating characteristics (sROC) curve was utilized to estimate the area under the curve (AUC).

Results
Of 22 studies, 21 were included in the quantitative synthesis. In the detection of intracerebral haemorrhage (ICH), DECT pooled overall sensitivity and specificity were 69.9% (95% CI, 44.5%-86.8%) and 100% (95% CI, 92.1%-100%); whereas, in the detection of ischaemia, they were 85.9% (95% CI, 80.4%-90%) and 90.7% (95% CI, 87%-93.5%), respectively. On the sROC curve, AUC values of 0.954 and 0.952 were recorded for the detection of ICH and ischaemia, respectively.

Conclusions
DECT demonstrated high accuracy and specificity in the detection of neurological complications post-endovascular treatment of AIS. However, further prospective studies with a standardized reference test and a larger sample size are recommended to support these findings.

Advances in knowledge
DECT is a rapid and valid imaging tool for the prediction of ICH and cerebral ischaemia after the EVT of AIS.
Transjugular approach: comparison with conventional endovascular treatment of native arteriovenous fistulas
Authors: Lee Dong Kyu , Cho Sung Bum , Kwak Jung Won , Min Hyeon Jin , Chung Hwan Hoon , Lee Seung Hwa , Song Myung Gyu , Sung Deuk Jae 
Published: January 2024

Abstract

Objectives
The aim of this study was to compare the outcomes of the transjugular approach with those of the conventional approach for endovascular treatment of arteriovenous fistulas (AVFs).

Methods
Between May 2015 and July 2019, 112 patients with endovascular treatment of dysfunctional or immature AVFs were included and divided into the transjugular (n = 46) and conventional (n = 66) groups. Electronic medical records and angiography of the patients were retrospectively reviewed to assess technical and clinical success rates, time to first fistulography, total procedure time, primary and secondary patency, and complications in both groups.

Results
There were no significant differences in technical success rate (87.0% vs 97.0%; P = .062), clinical success rate (80.4% vs 90.9%; P = .109), or total procedure time (60.2 vs 57.9 min; P = .670) between the groups. Cox proportional hazards models showed that the cumulative primary patency was significantly higher in the transjugular group than in the conventional group (P = .041; 6-month patency rates, 93.8% vs 91.5%). Also, a statistically significant difference was found between the cumulative secondary patency of the groups (P = .014; 6-month patency rates, 91.4% vs 86.5%). No major complications were observed.

Conclusions
Transjugular endovascular treatment of AVFs was successful and effective. Longer patency periods were observed when treated via transjugular access.

Advances in knowledge
This article compared the outcomes of transjugular approaches with those of conventional approaches in the endovascular treatment of native AVFs and showed higher patency periods/rates in the transjugular group than in the conventional group.
Imaging of musculoskeletal tuberculosis
Authors: Pattamapaspong Nuttaya , Kanthawang Thanat , Bouaziz Mouna Chelli , Ladeb Mohamed Fethi , Hammami Nadia , Peh Wilfred C G 
Published: January 2024

Abstract
Extra-pulmonary tuberculosis (TB) of the musculoskeletal system usually manifests with non-specific clinical features, mimicking a variety of diseases. Diagnosis and treatment of spinal and extra-spinal musculoskeletal TB are often challenging. Imaging has an important role in detecting this disease, aiding diagnosis, identifying complications, and monitoring disease progression. Radiographs and magnetic resonance imaging are the key imaging modalities utilized. Radiologists should aim to be familiar with the spectrum of imaging features of TB affecting spinal and extra-spinal locations in the musculoskeletal system.
Temporomandibular joint pathologies: pictorial review
Authors: Larheim Tore A , Hol Caroline , Løseth Guro , Arvidsson Linda Z 
Published: January 2024

Abstract
In this pictorial review, an introductory paragraph emphasizes the significance of some anatomical aspects for optimal imaging of the temporomandibular joint (TMJ). The most frequent pathologies: internal derangement (ID) and osteoarthritis (OA) are comprehensively discussed and illustrated. Less common conditions: ID and OA-like changes in children and adolescents, idiopathic condylar resorption, inflammatory arthritis, and juvenile idiopathic arthritis are briefly discussed. A short paragraph on differential diagnostics in young patients is included followed by a brief comment on expansile lesions that occasionally may occur in the TMJ.
Utility of 68Ga-DOTATATE PET-MRI for Gamma Knife® stereotactic radiosurgery treatment planning for meningioma
Authors: Ratnayake Gishan , Huo Michael , Mehta Akash , Ramachandran Prabhakar , Pinkham Mark B , Law Phillip , Watkins Trevor , Olson Sarah , Hall Bruce , Brown Simon , Lusk Ryan , Jones Catherine , O’Mahoney Eoin , McGill George , Foote Matthew C 
Published: January 2024

Abstract

Objectives
To investigate the impact of adding 68Ga-DOTATATE PET/MRI to standard MRI for target volume delineation in Gamma Knife® stereotactic radiosurgery (GKSRS) for meningioma.

Methods
Seventeen patients with 18 lesions undergoing GKSRS for WHO grade 1 meningioma were enrolled in a prospective study. All patients underwent pre-treatment 68Ga-DOTATATE PET/MRI examination in addition to standard procedures. Five clinicians independently contoured the gross tumour volume (GTV) based on standard MRI (GTVMRI) and PET/MRI (GTVPET/MRI) on separate occasions. Interobserver agreement was evaluated using Cohen’s Kappa statistic (CKS), Dice similarity coefficient (DC), and Hausdorff distance (HD). Statistical analysis was performed with paired t-test and Wilcoxon signed rank test.

Results
The addition of PET/MRI significantly increased GTV contour volume (mean GTVPET/MRI 3.59 cm3 versus mean GTVMRI 3.18 cm3, P = .008). Using the treating clinician’s pre-treatment GTVMRI as the reference, median CKS (87.2 vs 77.5, P = .006) and DC (87.2 vs 77.4, P = .006) were significantly lower, and median HD (25.2 vs 31.0, P = .001) was significantly higher with the addition of PET/MRI. No significant difference was observed in interobserver contouring reproducibility between GTVMRI and GTVPET/MRI.

Conclusion
The addition of 68Ga-DOTATATE PET/MRI for target volume delineation in GKSRS for meningioma is associated with an increase in GTV volume and greater interobserver variation. PET/MRI did not affect interobserver contouring reproducibility.

Advances in Knowledge
This study provides novel insights into the impact of 68Ga-DOTATATE PET/MRI on GTV delineation and interobserver agreement in meningioma GKSRS, highlighting its potential for improving GKSRS treatment accuracy.
Risk stratification of prostate cancer with MRI and prostate-specific antigen density-based tool for personalized decision making
Authors: Rajendran Ishwariya , Lee Kang-Lung , Thavaraja Liness , Barrett Tristan 
Published: January 2024

Abstract

Objectives
MRI is now established for initial prostate cancer diagnosis; however, there is no standardized pathway to avoid unnecessary biopsy in low-risk patients. Our study aimed to test previously proposed MRI-focussed and risk-adapted biopsy decision models on a real-world dataset.

Methods
Single-centre retrospective study performed on 2055 biopsy naïve patients undergoing MRI. Diagnostic pathways included “biopsy all”, “MRI-focussed” and two risk-based MRI-directed pathways. Risk thresholds were based on prostate-specific antigen (PSA) density as low (&lt;0.10 ng mL−2), intermediate (0.10-0.15 ng mL−2), high (0.15-0.20 ng mL−2), or very high-risk (&gt;0.20 ng mL−2). The outcome measures included rates of biopsy avoidance, detection of clinically significant prostate cancer (csPCa), missed csPCa, and overdiagnosis of insignificant prostate cancer (iPCa).

Results
Overall cancer rate was 39.9% (819/2055), with csPCa (Grade-Group ≥2) detection of 30.3% (623/2055). In men with a negative MRI (Prostate Imaging-Reporting and Data System, PI-RADS 1-2), the risk of cancer was 1.2%, 2.6%, 9.0%, and 12.9% in the low, intermediate, high, and very high groups, respectively; for PI-RADS score 3 lesions, the rates were 10.5%, 14.3%, 25.0%, and 33.3%, respectively. MRI-guided pathway and risk-based pathway with a low threshold missed only 1.6% csPCa with a biopsy-avoidance rate of 54.4%, and the risk-based pathway with a higher threshold avoided 62.9% (1292/2055) of biopsies with 2.9% (61/2055) missed csPCa detection. Decision curve analysis found that the “risk-based low threshold” pathway has the highest net benefit for probability thresholds between 3.6% and 13.9%.

Conclusion
Combined MRI and PSA-density risk-based pathways can be a helpful decision-making tool enabling high csPCa detection rates with the benefit of biopsy avoidance and reduced iPCa detection.

Advances in knowledge
This real-world dataset from a large UK-based cohort confirms that combining MRI scoring with PSA density for risk stratification enables safe biopsy avoidance and limits the over-diagnosis of insignificant cancers.
Utility of marking and fusion image-guided technique with cone-beam CT in kidney ruptured haemorrhage without extravascular leakage in angiography: a pilot study
Authors: Wang Zi-Xuan , Li Lin , Zhao Yi-Fan 
Published: January 2024

Abstract

Objective
To explore the feasibility of using marking and fusion image-guided technique with cone-beam CT (CBCT) in cases of kidney ruptured haemorrhage without extravascular leakage in digital subtraction angiography (DSA) images.

Methods
This is a retrospective case-control study that included 43 patients who underwent transcatheter arterial embolization for kidney ruptured haemorrhage and difficult haemostasis. The patients were divided into two groups: the CBCT group (cases without extravascular leakage observed in angiography) and the control group (cases with clearly identifiable target vessels in angiography). The baseline characteristics and clinical outcomes were collected and analysed.

Results
The results showed no statistically significant differences in the duration of the procedure and intraoperative blood transfusion between the control and CBCT groups (P &gt; .05). The study clarified that the CBCT group had a significantly higher rate of improvement of gross haematuria compared to the control group (P &lt; .05). The CBCT group showed a greater increase in haemoglobin and a lesser increase in creatinine. The clinical success rates were 87.5% in the control group and 90.9% in the CBCT group (P &gt; .05).

Conclusions
The marking and fusion image-guided technique is useful in cases of kidney ruptured haemorrhage without extravascular leakage of contrast agent. The technique is safe, feasible, and effective, and we believe it is superior to purely DSA-guidance.

Advances in knowledge
The use of the marking and fusion image-guided technique is recommended to overcome the challenge of undetectable target vessels during interventional procedures. This technique is considered as non-inferior to purely DSA-guided interventional procedures where the target vessels are clearly identifiable.
Impact of nutritional status on the outcome of transjugular intrahepatic portosystemic shunt in patients with cirrhosis: a systematic review
Authors: Giri Suprabhat , Anirvan Prajna , Chaudhary Mansi , Tripathy Taraprasad , Patel Ranjan Kumar , Rath Mitali Madhumita , Panigrahi Manas Kumar 
Published: January 2024

Abstract

Objectives
Malnutrition and sarcopenia have been reported to adversely affect the outcome of patients with cirrhosis of the liver. There is an emerging body of evidence suggesting malnutrition and sarcopenia increase the risk of hepatic encephalopathy (HE) and mortality after transjugular intrahepatic portosystemic shunt (TIPS). The current systematic review aims to determine whether the body of evidence supports an association between nutritional status and post-TIPS outcomes in patients with cirrhosis.

Methods
Electronic databases of PubMed, Embase, and Scopus were searched from inception to June 3, 2023, for studies analysing the effect of nutritional status on post-TIPS outcomes in patients with cirrhosis.

Results
A total of 22 studies were included in the systemic review. Assessment of sarcopenia was done by skeletal muscle index (SMI) at the L3 level, transversal psoas muscle thickness, psoas muscle density, malnutrition as per ICD, relative sarcopenia with excess adiposity, lipid profile, controlling nutritional status score, body composition analysis, hospital frailty risk score, and visceral and subcutaneous fat area index. Ten out of 12 studies in this systematic review showed a significant association with the incidence of post-TIPS HE. Thirteen out of 14 studies reported that the presence of malnutrition was associated with increased odds of mortality following TIPS. One study reported sarcopenia as an independent predictor of liver failure, and another study reported that Pre-TIPS SMI was an independent predictor of substantial improvement in post-TIPS SMI.

Conclusions
The current systematic review shows that the presence of pre-TIPS malnutrition or sarcopenia is an independent predictor of adverse outcomes after TIPS. Incorporating these parameters into present prediction models can provide additional prognostic information.

Advances in knowledge
Nutritional assessment should be part of the evaluation of patients planned for TIPS for prediction of adverse events after the procedure.
Is arterial spin labelling necessarily low perfusion for cavernous sinus venous malformation? A case of hyperperfusion cavernous sinus venous malformation
Authors: Luo Dan , Xiao Xinlan 
Published: January 2024

Abstract
Generally, due to the complexity of the skull base structures, it is difficult to differentiate cavernous vascular malformation and meningioma in the cavernous sinus area using conventional imaging studies. Cavernous sinus venous malformation are characterized by increased capillary masses without a direct arterial supply, typically leading to low perfusion. On the other hand, meningiomas receive arterial blood supply to the tumour and often exhibit high perfusion. So, arterial spin labelling (ASL) can be helpful in distinguishing between the 2 tumour types. However, in our specific case of a cavernous sinus venous malformation, the ASL imaging showed hyperperfusion. Further analysis revealed that this hyperperfusion on ASL can occur when cavernous sinus venous malformation is associated with arteriovenous fistula malformation.
Natural language processing to automate a web-based model of care and modernize skin cancer multidisciplinary team meetings
Authors: Ali Stephen R , Dobbs Thomas D , Tarafdar Adib , Strafford Huw , Fonferko-Shadrach Beata , Lacey Arron S , Pickrell William Owen , Hutchings Hayley A , Whitaker Iain S 
Published: January 2024

Abstract

Background
Cancer multidisciplinary team (MDT) meetings are under intense pressure to reform given the rapidly rising incidence of cancer and national mandates for protocolized streaming of cases. The aim of this study was to validate a natural language processing (NLP)-based web platform to automate evidence-based MDT decisions for skin cancer with basal cell carcinoma as a use case.

Methods
A novel and validated NLP information extraction model was used to extract perioperative tumour and surgical factors from histopathology reports. A web application with a bespoke application programming interface used data from this model to provide an automated clinical decision support system, mapped to national guidelines and generating a patient letter to communicate ongoing management. Performance was assessed against retrospectively derived recommendations by two independent and blinded expert clinicians.

Results
There were 893 patients (1045 lesions) used to internally validate the model. High accuracy was observed when compared against human predictions, with an overall value of 0.92. Across all classifiers the virtual skin MDT was highly specific (0.96), while sensitivity was lower (0.72).

Conclusion
This study demonstrates the feasibility of a fully automated, virtual, web-based service model to host the skin MDT with good system performance. This platform could be used to support clinical decision-making during MDTs as ‘human in the loop’ approach to aid protocolized streaming. Future prospective studies are needed to validate the model in tumour types where guidelines are more complex.
Experimental determination of relationship between intramolecular bond lengths and their stretching vibrational frequencies of N,N-dimethylformamide and acetonitrile molecules in the liquid state
Authors: Kameda Yasuo , Amo Yuko , Usuki Takeshi , Watanabe Hikari , Umebayashi Yasuhiro , Ikeda Kazutaka , Honda Takashi , Otomo Toshiya 
Published: January 2024

Abstract
Time-of-flight (TOF) neutron diffraction measurements have been carried out on pure liquid deuterated N,N-dimethylformamide (DMF-d7), acetonitrile (AN-d3), and their concentrated LiTFSA solutions to investigate the effect of intermolecular interaction to intramolecular bond lengths, rCO, of the DMF and rCN of the AN molecules in the liquid state. Intramolecular parameters of DMF and AN are determined by least-squares fitting analyses of neutron total interference terms observed in the high-Q region. Attenuated total reflection (ATR) IR spectra have been measured for pure liquid DMF, AN, and their LiTFSA solutions of natural abundances to determine the average C=O and C≡N stretching vibrational frequencies (νCO and νCN) of the DMF and AN molecules, respectively. The relationships between rCO and νCO for DMF, and between rCN and νCN for AN, are well approximated by linear functions. The value, dνCO/drCO = −3,400 ± 1,600 cm−1 Å−1 has been derived for DMF from the slope of the fitted function. dνCN/drCN = −7,000 ± 3,000 cm−1 Å−1 has been obtained for AN. It has been revealed that the C = O bond length of the DMF and the C≡N one of the AN molecules are sensitively affected by intermolecular interaction.
Analysis of the structural H/D isotope effect with an excess proton/deuteron in light/heavy water solvent using path integral molecular dynamics simulations
Authors: Tatenuma Kazuki , Takagi Makito , Shimazaki Tomomi , Tachikawa Masanori 
Published: January 2024

Abstract
We analyzed the difference in the structural H/D isotope effect between an excess proton in light water (H-body) and an excess deuteron in heavy water (D-body), including the nuclear quantum effect, using path integral molecular dynamics simulations. We found that the second peak of the H-body is shorter than that of the D-body in the radial distribution function of O*–O, where O* is the oxygen atom of the H3O+/D3O+ fragment. The main reason for this would be the difference in the ratio of the Zundel structure with the sp3-like configuration, where the Zundel structure in the H-body (14.0%) is greater than that in the D-body (12.0%). We also found rare occurrences of double H3O+/D3O+ configurations, mainly including Zundel–Zundel-like structures such as H7O3+/D7O3+ and H9O4+/D9O4+. The ratios of such configurations appearing in our simulations are 0.89% and 0.20% for the H-body and the D-body, respectively.
Highly specific and sensitive detection of bacteria by dark-field light-scattering imaging based on bacteriophage-modified magnetoplasmonic nanoparticles
Authors: Imai Masashi , Uchiyama Jumpei , Takemura-Uchiyama Iyo , Matsuzaki Shigenobu , Niko Yosuke , Hadano Shingo , Watanabe Shigeru 
Published: January 2024

Abstract
Bacterial infections pose significant global health concerns, necessitating precise and sensitive detection methods. This study introduces a multifunctional probe for bacterial detection. Bifunctional magnetoplasmonic nanoparticles (NPs) serve a dual purpose as carriers for magnetic separation (MS) and enhancers for light scattering of the target bacteria. We achieved exceptional selectivity at the bacterial species level by bioconjugating them with bacteriophages (phages). Optimal phage coverage was carefully determined to enhance the capture efficiency of the target bacterial cells. Additionally, we identified the ideal mixing ratios of the phage probe to bacteria, ensuring efficient MS and high light-scattering intensity. The use of the phage probe enabled the successful separation of captured target bacteria from other bacterial strains in the sample mixture. Bacterial detection was accomplished through dark-field light-scattering imaging, eliminating the need for additional labeling with other probes. This method showed a remarkable sensitivity, achieving a detection limit of ∼102  colony-forming units ml−1. This value is 2 orders of magnitude lower than that achieved using our previously reported technique using monofunctional plasmonic NPs. These phage probes hold promise for healthcare, biotech, and environmental monitoring owing to their adaptability to diverse bacterial species.
Possibility of Nickel(I) complex in Suzuki-Miyaura coupling using pincer-type 1,2,3-triazolylidene Nickel(II) complex
Authors: Tomomatsu Kanta , Yamada Yuji , Koga Yuji , Matsubara Kouki 
Published: January 2024

Abstract
The catalytic behavior of Ni(II) complexes bearing a tridentate 1,2,3-triazolylidene ligand in the Suzuki-Miyaura coupling of bromoarenes was studied experimentally and theoretically. The reaction of Ni(II) complex with K3PO4 produced a paramagnetic Ni(I) species rather than a 2e-reduced Ni(0) species. A Ni(II)–phenyl complex was obtained via transmetalation; however, it was inactive during the catalytic process. A theoretical study also indicated the possibility of using Ni(I) species as intermediates in the catalytic process.