bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion
Authors: Cheruiyot Abigael , Hollister-Lock Jennifer , Sullivan Brooke , Pan Hui , Dreyfuss Jonathan M. , Bonner-Weir Susan , Schaffer Jean E. 
Published: September 2023

AbstractPancreatic β-cells are specialized for coupling glucose metabolism to insulin peptide production and secretion. Acute glucose exposure robustly and coordinately increases translation of proinsulin and proteins required for secretion of mature insulin peptide. By contrast, chronically elevated glucose levels that occur during diabetes impair β-cell insulin secretion and have been shown experimentally to suppress insulin translation. Whether translation of other genes critical for insulin secretion are similarly downregulated by chronic high glucose is unknown. Here, we used high-throughput ribosome profiling and nascent proteomics in MIN6 insulinoma cells to elucidate the genome-wide impact of sustained high glucose on β-cell mRNA translation. Prior to induction of ER stress or suppression of global translation, sustained high glucose suppressed glucose-stimulated insulin secretion and downregulated translation of not only insulin, but also of mRNAs related to insulin secretory granule formation, exocytosis, and metabolism-coupled insulin secretion. Translation of these mRNAs was also downregulated in primary rat and human islets followingex-vivoincubation with sustained high glucose and in anin vivomodel of chronic mild hyperglycemia. Furthermore, translational downregulation decreased cellular abundance of these proteins. Our findings uncover a translational regulatory circuit during β-cell glucose toxicity that impairs expression of proteins with critical roles in β-cell function.
NMD targets experience deadenylation during their maturation and endonucleolytic cleavage during their decay
Authors: Viscardi Marcus J. , Arribere Joshua A. 
Published: September 2023

ABSTRACTPremature stop codon-containing mRNAs can produce truncated and dominantly acting proteins that harm cells. Eukaryotic cells protect themselves by degrading such mRNAs via the Nonsense-Mediated mRNA Decay (NMD) pathway. The precise reactions by which cells attack NMD target mRNAs remain obscure, precluding a mechanistic understanding of NMD and hampering therapeutic efforts to control NMD. A key step in NMD is the decay of the mRNA, which is proposed to occur via several competing models including deadenylation, exonucleolytic decay, and/or endonucleolytic decay. We set out to clarify the relative contributions of these decay mechanisms to NMD, and to identify the role of key factors. Here, we modify and deploy single-molecule nanopore mRNA sequencing to capture full-length NMD targets and their degradation intermediates, and we obtain single-molecule measures of splicing isoform, cleavage state, and poly(A) tail length. We observe robust endonucleolytic cleavage of NMD targetsin vivothat depends on the nuclease SMG-6 and we use the occurence of cleavages to identify several known NMD targets. We show that NMD target mRNAs experience deadenylation, but similar to the extent that normal mRNAs experience as they enter the translational pool. Furthermore, we show that a factor (SMG-5) that historically was ascribed a function in deadenylation, is in fact required for SMG-6-mediated cleavage. Our results support a model in which NMD factors act in concert to degrade NMD targets in animals via an endonucleolytic cleavage near the stop codon, and suggest that deadenylation is a normal part of mRNA (and NMD target) maturation rather than a facet unique to NMD. Our work clarifies the route by which NMD target mRNAs are attacked in an animal.
Severe nomophobia is a predictor of poor road safety among motorists
Authors: Jahrami Haitham 
Published: September 2023

PurposeUsing a mobile phone is increasingly becoming recognized as very dangerous while driving. With a smartphone, users feel connected and have access to information. The inability to access smartphone has become a phobia, causing anxiety and fear. The present study’s aims are as follows: first, quantify the association between nomophobia and road safety among motorists; second, determine a cut-off value for nomophobia that would identify poor road safety so that interventions can be designed accordingly.Design/methodology/approachParticipants were surveyed online for nomophobia symptoms and a recent history of traffic contraventions. Nomophobia was measured using the nomophobia questionnaire (NMP-Q).FindingsA total of 1731 participants responded to the survey; the mean age was 33 ± 12, and 43% were male. Overall, 483 (28%) [26–30%] participants received a recent traffic contravention. Participants with severe nomophobia showed a statistically significant increased risk for poor road safety odds ratios and a corresponding 95% CI of 4.64 [3.35-6.38] and 4.54 [3.28-6.29] in crude and adjusted models, respectively. Receiver operator characteristic (ROC)-based analyses revealed that NMP-Q scores of = 90 would be effective for identifying at risk drivers with sensitivity, specificity and accuracy of 61%, 75% and 72%, respectively.Originality/valueNomophobia symptoms are quite common among adults. Severe nomophobia is associated with poor road safety among motorists. Developing screening and intervention programs aimed at reducing nomophobia may improve road safety among motorists.
Environmental concern and purchase intention of pre-loved luxury products: a moderated mediation model
Authors: Malhotra Gunjan , Shaiwalini Shipra 
Published: September 2023

PurposeThis research paper aims to examine consumers' perceptions and behaviours towards “pre-loved luxury fashion products” and focusses on analysing the moderating influence of consumers' attitude strength. Additionally, it investigates the impact of desirability in sustainable luxury experiences (LEs) on consumers' purchase intentions (PIs). The study draws inspiration from the Norm Activation Model theory and operationalises attitude strength using the Elaboration Likelihood Model theory.Design/methodology/approachPurposive sampling technique was employed to collect 317 useable samples from respondents who had previously purchased or intended to purchase pre-loved luxury fashion goods. SPSS and AMOS version 25 was used for data analysis.FindingsThe findings reveal that consumers' environmental concern influences their intention to purchase pre-loved luxury fashion products. Furthermore, sustainable LE acts as a significant mediator in this relationship. The study also demonstrates that the intention to purchase pre-loved luxury fashion products is strengthened when consumers possess a strong attitude towards them.Practical implicationsLuxury marketers can strategise accordingly to motivate consumers to purchase pre-loved luxury fashion products by resonating with their cultural correlates through persuasive advertising to favourably affirm their attitude towards pre-loved luxury fashion products.Originality/valueThis study contributes to the literature by addressing the unresolved area of PIs for pre-loved luxury fashion products, considering the moderating role of attitude strength in emerging markets. It highlights the significance of advocating and promoting pre-loved luxury fashion products and provides valuable insights for luxury marketers.
Stuck between the ideal worker and the bread winner: experiences of motherhood and work during the COVID-19 pandemic in India
Authors: Kataria Priya , Pandey Shelly 
Published: September 2023

PurposeThe purpose of this paper is to study the experiences of middle-class working mothers from the ITES (Information Technology Enabled Service) sector in India during the COVID-19 pandemic. Their experiences of work from home are studied in the backdrop of the ideal worker model at work and the adult worker model at home. Further, the study aims to identify the need for sustainable, inclusive practices for working mothers in Indian organizations to break the male breadwinner model in middle-class households.Design/methodology/approachA qualitative approach to collect data from 39 middle-class mothers working in MNCs in four metro cities in India. The semi-structured, in-depth interviews focused on their experiences of motherhood, care and work before, during and after the COVID-19 pandemic.FindingsThe pandemic made it evident that the ideal worker model in organizations and the adult worker model at home were illusions for working mothers. The results indicate a continued obligation of the “ideal worker culture” at organizations, even during the health crisis. It made the working mothers realize that they were chasing both the (ideal worker and adult worker) norms but could never achieve them. Subsequently, the male breadwinner model was reinforced at home due to the matrix of motherhood, care and work during the pandemic. The study concludes by arguing the reconstruction of the ideal worker image to make workplaces more inclusive for working mothers.Originality/valueThe study is placed in the context of Indian middle-class motherhood during the pandemic, a demography less explored in the literature. The paper puts forth various myths constituting the gendered realities of Indian middle-class motherhood. It also discusses sustainable, inclusive workplace practices for mothers from their future workplaces' standpoint, especially in post-pandemic times.
Does black-box supplier involvement help buyers' product modular and architectural innovation? The moderating role of product modularity
Authors: Li Yuzhong 
Published: September 2023

PurposeIn product modular design tasks, especially in the high-tech manufacturing industry, buyers and supplies play distinct roles, which may have different impacts on product architectural and modular innovation. Prior research has tended to view product innovation as a holistic concept, overlooking the importance of this differentiated influence. This study, from a modular design perspective, aims to clarify the impact of black-box supplier involvement on product architectural and modular innovation, as well as the influence of product modularity on these relationships.Design/methodology/approachBased on the theory of product modular design, this study decomposes product innovation into architectural and modular innovation from the perspective of the product internal structure to conduct in-depth theoretical analysis and model construction. A total of 276 valid questionnaires are collected from typical Chinese high-tech manufacturing firms and used to empirically test the constructed theoretical model using multiple hierarchical regression analysis.FindingsThe results show that black-box supplier involvement positively affects modular innovation and takes an inverted U-shape, as moderated by product modularity. However, the impact of black-box supplier involvement on architectural innovation shows contradictory differences at different modularity levels. Under a low level of product modular design, black-box supplier involvement has a negative impact on architectural innovation, but under a moderate level of modular design, it has a positive impact. After the degree of modular design exceeds a certain threshold, the impact gradually weakens.Practical implicationsThe results provide valuable insights for managers, highlighting the need to avoid oversimplifying the innovation impact of black-box suppliers solely based on overall product innovation. Instead, a more accurate assessment of the innovation contributions of both the buyer and supplier should be based on the degree of architectural and modular innovation. Additionally, the findings suggest that managers should consider the alignment between their company's product modular design features and innovation priorities (i.e. modular innovation or architectural innovation) when determining an appropriate supplier collaborative development strategy.Originality/valueThis study not only reveals the different impacts of black-box supplier involvement on architectural and modular innovation, but also proves the significant synergistic innovation effect of the relationship between black-box supplier involvement and product modularization. It constitutes an enriched and deepened exploration in the existing research on supplier involvement in product innovation.
Can leaders enhance followers' psychological capital? A framework to support leader–member exchange for sustainable organizations
Authors: Feng Xueling , Adams Donnie 
Published: September 2023

PurposeServant leadership suggests that leaders should focus on the betterment and psychological needs of their followers at work. However, little is known about the relationships among servant leadership, leader–member exchange (LMX) and psychological capital (PsyCap) in the field of education. The purpose of this paper is to propose a conceptual framework on the mediating role of LMX in the relationship between servant leadership and followers' PsyCap based on theory and previous empirical research, particularly in the context of higher education.Design/methodology/approachTo achieve the purpose of the study, a review of literature was conducted to develop a conceptual framework.FindingsFindings suggested that servant leadership can positively influence followers' PsyCap via the mediating effect of LMX.Originality/valueBy positing that servant leadership affects followers' PsyCap via LMX in the context of higher education, this paper's framework lays a strong foundation for the expansion of the servant leadership knowledge base as well as for future theory development and debate.
A decision support method for credit risk based on the dynamic Bayesian network
Authors: Lu Jie , Wu Desheng , Dong Junran , Dolgui Alexandre 
Published: September 2023

PurposeCredit risk evaluation is a crucial task for banks and non-bank financial institutions to support decision-making on granting loans. Most of the current credit risk methods rely solely on expert knowledge or large amounts of data, which causes some problems like variable interactions hard to be identified, models lack interpretability, etc. To address these issues, the authors propose a new approach.Design/methodology/approachFirst, the authors improve interpretive structural model (ISM) to better capture and utilize expert knowledge, then combine expert knowledge with big data and the proposed fuzzy interpretive structural model (FISM) and K2 are used for expert knowledge acquisition and big data learning, respectively. The Bayesian network (BN) obtained is used for forward inference and backward inference. Data from Lending Club demonstrates the effectiveness of the proposed model.FindingsCompared with the mainstream risk evaluation methods, the authors’ approach not only has higher accuracy and better presents the interaction between risk variables but also provide decision-makers with the best possible interventions in advance to avoid defaults in the financial field. The credit risk assessment framework based on the proposed method can serve as an effective tool for relevant policymakers.Originality/valueThe authors propose a novel credit risk evaluation approach, namely FISM-K2. It is a decision support method that can improve the ability of decision makers to predict risks and intervene in advance. As an attempt to combine expert knowledge and big data, the authors’ work enriches the research on financial risk.
The influence of family dynamics on business performance: does effective leadership matter?
Authors: Maharajh Reshmini , Dhliwayo Shepherd , Chebo Abdella Kosa 
Published: September 2023

PurposeFamily businesses have a dual objective of profit making and providing opportunities for family members. This duality leads to a conflict that may bring poor team work and communication, which is difficult to reconcile. Thus, the study looked into how the performance of family enterprises is affected by family dynamics. Additionally, it examines the relationship's ability to be mediated by effective leadership.Design/methodology/approachThe study adopted a quantitative, explanatory research approach. The study population was family-owned enterprises in KwaZulu-Natal's South Durban Basin, of which 236 were chosen using a snowball and convenience sampling technique. Data was analysed using various descriptive and inferential statistical techniques, namely, multiple regression and the standard deviation.FindingsThe finding of the study shows that family dynamics significantly influenced business performance both directly and indirectly through effective leadership. Besides, the family firms with larger employee sizes have better effective leadership that positively contributes to the business performance.Research limitations/implicationsThe study recommends that family businesses should train their members to ensure leadership effectiveness.Originality/valueThis study is unique in that it was conducted in Black Townships and focusses mainly on businesses owned by families of Indian descent that need to prepare for leadership/ownership. It also contributes to academic literature on family dynamics and will encourage families to recognise the importance of strong leadership in controlling family dynamics to improve business success.
Femvertising social marketing: a focus on perceived authenticity and perceived congruence of the advertising and consumers' attitudes toward female portrayal
Authors: Negm Eiman Medhat 
Published: September 2023

PurposeThis research studies femvertising social marketing impact on their perceived congruence and authenticity; and attitudes toward female role portrayal cross-gender.Design/methodology/approachThis research used deductive quantitative research approach. Data were gathered during a sports event in Egypt made to support female empowerment; a local sports organization hosted 8K Women Race on February 26, 2022, applying a cross-sectional timeframe. The researcher approached both male and female segments with an administrated questionnaire to fill out through convenience sampling. Structural equation modeling path coefficient analysis was used to test the hypotheses.FindingsThe research shows femvertising perceived congruence is insignificant cross-gender; femvertising perceived authenticity is significant to female segment, not the male segment; femvertising impacts female portrayal among male segment and female segment.Practical implicationsThe conclusions could be reference for stakeholders who have interest in women empowerment marketing strategies as brand activism; companies that look toward femvertising as effective tactic to enhance affirmative attitude and build an empowered female customer base. The results indicate that marketers can benefit from adapting a more mindful approach to the portrayal of females used in advertising.Originality/valueThe addition of a cross-gender perspective on femvertising (as brand activism) is a key contribution to this literature. This study adds knowledge on the how perceived congruence and authenticity of the advertising can impact significantly attitude toward women empowerment; when brands promote social matters, their underpinning motives are under microscope among consumers, and adverse attributions can hinder brand performance as consumers may not believe the brands when they engage in the activism.
The link between lean manufacturing and Industry 4.0 for product development process: a systemic approach
Authors: Tardio Paulo Roberto , Schaefer Jones Luís , Nara Elpidio Oscar Benitez , Gonçalves Marcelo Carneiro , Dias Izamara Cristina Palheta , Benitez Guilherme Brittes , Castro e Silva Andreia de 
Published: September 2023

Purpose This research examines the impact of integrating lean manufacturing (LM) principles and Industry 4.0 (I4.0) into the product development process (PDP) of manufacturing companies in southern Brazil, with the objective of improving market performance (MP).Design/methodology/approachA survey was conducted with 110 product development managers to evaluate the level of LM and I4.0 principles, PDP phases, and the improvement of MP. Quantitative analysis was employed to analyse the data, including confirmatory factor analysis (CFA) and ordinary least squares (OLS) hierarchical regression.FindingsThe study reveals that integrating LM and I4.0 principles in the PDP enhances product development and positively impacts the MP of manufacturing companies. Additionally, I4.0 partially mediates the LM-PDP relationship, while LM partially mediates the I4.0-PDP relationship, highlighting their interdependence rather than one being a prerequisite for the other.Research limitations/implicationsThe study has limitations regarding its narrow focus on product development managers in Brazil and the absence of multiple case studies.Practical implicationsThe study emphasises the importance of coordinated efforts in manufacturing companies to adopt and manage both LM and I4.0 principles, as they positively impact all phases of the PDP and ultimately contribute to the overall MP of the companies.Originality/valueThe novelty of this study lies in its systemic approach, examining the relationships and effects of LM and I4.0 principles on the PDP, and demonstrating how these effects manifest in manufacturing companies.
Stimulating exploitative and exploratory innovation through transformational leadership and knowledge management capability: the moderating role of competitive intensity
Authors: Le Phong Ba , Le Hung Manh 
Published: September 2023

PurposeGiven the importance of leadership practices and knowledge resources in fostering innovation capabilities of firms, the purpose of this study is to explore the influence of transformational leadership on exploitative and exploratory innovation via mediating role of knowledge management capability. This study also attempts to increase understanding of the appropriate mechanisms for firms to pursue innovation capability by examining the moderating mechanism of competitive intensity.Design/methodology/approachThis study utilized the structural equation modeling and cross-sectional design to test hypotheses in the proposed research model using survey data collected from 351 participants in 120 manufacturing and service firms.FindingsThe findings indicate that transformational leadership induces greater effect on exploratory innovation compared to its effect on exploitative innovation. The mediating role of knowledge management capability between transformational leadership and aspects of innovation capability is also supported. Especially, the influences of knowledge management capability on exploratory innovation capability are enhanced and depended on the degree of competitive intensity.Research limitations/implicationsFuture research should examine the mediating mechanisms of knowledge acquisition, knowledge sharing and knowledge application to provide deeper insight on the role of specific components of knowledge management capability in linking transformational leadership and innovation capability.Practical implicationsThe paper highlights the important role of transformational leadership practices for fostering knowledge management capability and specific aspects of innovation capability under high level of competitive pressure.Originality/valueThe paper is unique in the attempts to provide a prospective solution for firms to pursue and improve innovation based on the meaningful insights on the mediating role of knowledge management capability and moderating effect of competitive intensity in the relationship between transformational leadership and specific dimensions of innovation capability.