bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating Single-cell and Bulk RNA Sequencing Reveals Stemness
Phenotype Associated with Clinical Outcomes and Potential Immune
Evasion Mechanisms in Hepatocellular Carcinoma
Authors: Zhu Xiaojing , Zhang Jiaxing , Zhang Zixin , Yuan Hongyan , Xie Aimin , Zhang Nan , Wang Minwei , Jiang Minghui , Xiao Yanqi , Wang Hao , Wang Xing , Xu Yan 
Published: December 2023

Aims:
Bulk and single-cell RNA sequencing data were analyzed to explore the association
of stemness phenotype with dysfunctional anti-tumor immunity and its impact on clinical outcomes
of primary and relapse HCC.

Background:
The stemness phenotype is gradually acquired during cancer progression; however, it
remains unclear the effect of stemness phenotype on recurrence and clinical outcomes in hepatocellular
carcinoma (HCC).

Methods:
The stemness index (mRNAsi) calculated by a one-class logistic regression algorithm in
multiple HCC cohorts was defined as the stemness phenotype of the patient. Using single-cell profiling
in primary or early-relapse HCC, cell stemness phenotypes were evaluated by developmental potential.
Differential analysis of stemness phenotype, gene expression and interactions between primary
and recurrent samples revealed the underlying immune evasion mechanisms.

Results:
A strong correlation was discovered between mRNAsi and clinical outcomes in patient with
HCC. The high and low mRNAsi groups had distinct tumor immune microenvironments. Cellular
stemness phenotype varied by cell type. Moreover, compared with primary tumors, early-relapse tumors
had increased stemness of dendritic cells and tumor cells and reduced stemness of T cells and B
cells. Moreover, in relapse tumors, CD8+ T cells displayed a low stemness state, with a high exhausted
state, unlike the high stemness state observed in primary HCC.

Conclusions:
The comprehensive characterization of the HCC stemness phenotype provides insights
into the clinical outcomes and immune escape mechanisms associated with recurrence.
Evaluation of Soft Tissue Changes Following Platelet-rich Fibrin in Immediate Implantation of Posterior Teeth: A Randomized Clinical Trial
Authors: Moeintaghavi Amir , Ghanbari Habibollah , Arab Hamidreza , Shiezadeh Farid , Jamali Mounes 
Published: December 2023

Background:
Currently, immediate implant placement is favored due to its reduced number of surgical appointments and shorter overall treatment duration. However, a notable disadvantage of this protocol is the inadequate dimension of soft tissue surrounding the implant, which presents a challenge for immediate implantation in posterior teeth. As a result, patients frequently necessitate soft tissue augmentation to alleviate potential complications. In this randomized clinical trial study, a minimally invasive technique utilizing platelet-rich fibrin (PRF) was employed to enhance soft tissue thickness and keratinized tissue width during immediate implantation in the posterior region of the jaw.

Methods and Materials:
A total of 20 bone-level implants were utilized in 20 patients through the immediate implantation protocol. In order to augment soft tissue, 10 patients were subjected to treatment with platelet-rich fibrin (PRF) on immediate implants in the test group, while 10 patients received connective tissue graft (CTG) on immediate implants in the control group. After a period of 3 months, all implants were uncovered through surgery, and healing abutments were placed on fixtures. Keratinized tissue width was measured using a periodontal probe at baseline, 1 month, and 3 months after implant placement, while soft tissue thickness was measured at baseline and 3 months after implant placement.

Results:
Treatment was successful for all the patients. The average keratinized tissue width in the test and control group was 3.45 and 2.65 at baseline, 4.00 and 3.40 one month after surgery, and 4.20 and 3.85 three months after implant placement, respectively. Average keratinized tissue thickness in the test and control group was 2.45 and 2.05 at baseline and 3.20 and 3.25 at reentry (three months after implant placement), respectively. The average increase in keratinized tissue thickness from baseline to 3rd month was 0.75 in the test and 1.20 in the control group. The average increase in keratinized tissue width from baseline to 1st month was 0.55 in the test and 0.75 in the control group, and from baseline to 3rd month, it was 0.75 in the test and 1.20 in the control group, respectively. Data for both parameters in each group from baseline to 3rd month were statistically significant. Data for keratinized tissue thickness (p=0.077) and keratinized tissue width (p=0.089) between both the groups were not statistically significant.

Conclusion:
Platelet-rich fibrin (PRF) has the potential to serve as a minimally invasive approach for augmenting soft tissue in the posterior region of the jaw during immediate implant placement.

Clinical Trial Registration Number:
The clinical trial registration number for this study is IRCT20190723044313N1.
A Comprehensive Study of Allium Sativum Linn
Authors: Sah Roshan , Singh Manish Pal , Gohil Kashmira J. 
Published: December 2023

Abstract:
Allium sativum, commonly known as garlic, has been employed for ages for both cui-sines and restorative purposes. Many sulfur-containing phytochemical constituents are abundant in garlic and they are responsible for its many pharmacological properties. The most extensively studied compound in garlic is allicin, however, other forms of garlic such as aged garlic, raw garlic, and oil maceration of garlic, have their own unique chemical properties. Garlic has been shown to lower blood pressure, reduce cholesterol levels, improve insulin sensitivity, inhibit cell prolifera-tion, enhance peristalsis motion, modulate acetylcholine, and inhibit lipid oxidation. Apart from all its traditional therapeutic activity, it has much more potential for further study such as cancer treatment with lesser side-effects, improving mitochondrial dysfunction in Huntington’s disease, enhancement psoriasis treatment, affinity to treat glomerular disease, and vast scope in polycystic ovary syndrome and in uterine contraction. This review talks about pharmacology activities, future aspects, phytochemicals, and the privileged aspects of Allium sativum.
Confiabilidad y validez del Cuestionario de Cultura de Seguridad del Paciente en los Hospitales
Authors: Cuadros-Carlesi K. , Leal-Kaymalyz C. , Henríquez-Roldán C. , Godoy-Godoy S. 
Published: December 2023

Introducción: La cultura de seguridad es clave para disminuir los riesgos asociados a la atención sanitaria, ya que conduce a las organizaciones hacia el logro de la máxima seguridad posible. Por ello, su evaluación sistemática es primordial para la gestión de riesgos en los hospitales.
Objetivo: Evaluar la confiabilidad y validez del Cuestionario de Cultura de Seguridad del Paciente en los Hospitales, elaborado por la Agency for Healthcare Research and Quality, en un hospital de Chile.
Metodología: Investigación cuantitativa, analítica, de corte transversal. Se aplicó el cuestionario a una muestra no aleatoria de 225 enfermeras y técnicos en enfermería. Para evaluar la consistencia interna se utilizaron los coeficientes de α-Cronbach, λ6-Guttman y ω-McDonald. Para examinar la validez de constructo se realizó análisis factorial exploratorio.
Resultados: Los coeficientes de confiabilidad para los ítems del cuestionario fueron mayores a 0.89. Se detectaron tres dimensiones con problemas de consistencia interna: Percepción de la seguridad, Franqueza en la comunicación y Trabajo en equipo entre unidades. El análisis factorial exploratorio planteó entre 12 y 13 dimensiones.
Discusión: La evaluación de la cultura de seguridad es relevante para lograr los objetivos del Plan Global de Seguridad del Paciente, siendo esencial disponer de instrumentos adaptados culturalmente, válidos y confiables que faciliten la toma de decisiones organizacionales y permitan evaluar el impacto de estas a lo largo del tiempo.
Conclusiones: El cuestionario responde adecuadamente a la consistencia interna y tiende a agrupar 12 dimensiones. No obstante, requiere ajustes en ítems problemáticos de tres dimensiones con baja consistencia interna.
Seismic facies characterization using Rock Physics Templates and brittleness indices: Stybarrow field
Authors: López-Aguirre Daniel , Domínguez-Cruz Miguel Ángel , España-Pinto José Aurelio , Valdiviezo-Mijangos Oscar Cerapio , Nicolás-López Rubén 
Published: December 2023

This paper proposes a method for identifying the lithological properties of the medium based on the joint analysis of the Lamé parameters, Young's Modulus, and Poisson's Ratio. Additionally, an analysis of brittleness was proposed to identify brittle/ductile intervals and areas of potential reservoirs. The petroelastic properties were analyzed at well and seismic scales using ternary rock physics templates. The ternary templates were built from a self-consistent micromechanical model. In addition, the analysis allows for preserving the conditions of the environment subsurface in the seismic and log information. A workflow for petroelastic lithology interpretation was coupled with a workflow of brittleness modeling. The results correlate well with conventional qualitative methodologies applied in previous studies. A brittleness analysis methodology was developed and tested to identify reservoirs associated with the Lower Cretaceous in the Stybarrow field in Australia; the results highlight the high brittleness zones attenuated by hydrocarbons ( ). The proposed seismic-based methodology is an improvement to conventional analysis trends for identifying lithologies and prospective hydrocarbon zones.
Pengembangan Media Roda Berputar (Rotar) Dalam Pembelajaran IPA Kelas V SD Negeri 2 Trikarya
Authors: Saputra Iksan , Rosalina Elya , Egok Asep Sukenda 
Published: December 2023

Penelitian ini bertujuan untuk mengembangkan media roda berputar (rotar) dalam pembelajaran IPA kelas V SD Negeri 2 Trikarya. Jenis penelitian ini yakni Research and Development dengan model pengembangan 4D. Subjek penelitian ini berjumlah 24 siswa. Teknik pengumpulan data yakni wawancara, angket dan tes. Berdasarkan hasil uji kevalidan diperoleh skor keseluruhan sebesar 0,81 dengan kategori tinggi. Hasil dari uji kepraktisan dengan skor rata-rata keseluruhan 94,21Â dengan kategori sangat praktis. Dan hasil dari uji efektifitas dengan skor rata-rata keseluruhan 0,77 dengan kategori tinggi, sehingga dapat disimpulkan bahwa media roda berputar (rotar) memenuhi kriteria valid, praktis dan efektivitas.Â
Penerapan Model Problem Based Learning Berbantuan Geogebra Classroom Untuk Meningkatkan Motivasi Belajar Peserta Didik
Authors: Puspasari Ayu Erika 
Published: December 2023

Penelitian ini bertujuan untuk meningkatkan motivasi belajar peserta didik melalui penerapan modelÂ Problem Based Learning berbantuan Geogebra ClassroomÂ pada peserta didik kelas XII MIPA 2 di SMA Negeri 2 Pagaden. Penelitian ini merupakan penelitian tindakan kelas yang terdiri dari dua siklus dengan tiap siklus terdiri atas tahap perencanaan, pelaksanaan, observasi, evaluasi dan refleksi. Hasil motivasi belajar peserta didik diperoleh melalui angket dan data hasil belajar peserta didik diperoleh melalui tes evaluasi pada akhir tiap siklus. Hasil penelitian menunjukkan bahwa terdapat peningkatan skor angket motivasi belajar peserta didik sebesar 16,55. Selain itu, jika dilihat dari tes hasil belajar peserta didik terdapat peningkatan rata-rata sebesar 9 dan juga tingkat kelulusan sebesar 15%. Berdasarkan hasil ini terlihat bahwa dengan meningkatnya motivasi peserta didik maka pemahaman peserta didik juga ikut meningkat karena peserta didik terlibat secara aktif dalam penyelesaian masalah. Dengan demikian Problem Based Learning berbantuan Geogebra Classroom berdampak positif terhadap peserta didik terutama motivasi belajar peserta didik. Oleh karena itu, Problem Based Learning berbantuan Geogebra Classroom disarankan untuk diterapkan dalam pembelajaran matematika.
A Journey through language and diversity in the English-speaking community: from its origins to the Colombian case
Authors: Catullo MacIntyre Luca Tommaso , Vergara Restrepo Mateo , Otálvaro Arango Santiago 
Published: December 2023

This article is meant to be a journey through the English community and its diversity, depicted by a variety of people, accents and dialects existing in several native English-speaking countries. It is a brief but meaningful historical background, which starts from the Anglo-Saxon invasion of the British Isles, in the fifth century of our era, and it continues until the spread of English as an international language. A fairly relevant part is also dedicated to the first dispersal of ‘Englishes’, people who migrated from the south-east of England mostly to North America and Australia, giving birth to new and meaningful linguistic varieties.
The impact of English on higher education will be extensively analysed and discussed; this includes the brand-new role of twentieth-century English teachers, as well as the history of English in Colombia and its influence in culture, education and language policies, from its origins to its current handling.
Peculiarities of Accounting Practices in Francesco Datini’s Partnership in Pisa
Authors: Kuter Mikhail , Baker Charles Richard , Gurskaya Marina , Sagitova Roza 
Published: December 2023

ABSTRACT
This study examines how bookkeeping was used to determine the financial results of the Datini Partnership in Pisa in the late 14th century. It highlights the difference between accounting procedures in a medieval partnership and accounting procedures in individual medieval enterprises and over time. Building upon previous studies, the analysis of archival documents and the construction of a model of the flow of information between accounts and account books reveals the details of the bookkeeping procedures in the firm and a complete picture of the calculation of the financial result of the partnership in 1394. The study found that the need for the partnership to identify profits resulted in a change in the bookkeeping method for inventory that improved the information quality when used in the process of identifying operating results and the overall financial result.
JEL Classifications: M41; N83.
Validity and reliability of the evaluation tool of TCM confidence in students with TCM learning experience
Authors: Jia Rui-Min , Yan Xiao-Ning , Liu Xing-Yu , Wang Jin-Nan 
Published: December 2023

Abstract

Objective
This study aimed to design an evaluation scale of traditional Chinese medicine (TCM) confidence and then evaluate its validity and reliability.

Methods
Three parallel samples with TCM learning experience were included in this current study. Randomly selected 500 nursing students were included factor analysis and reliability and validity analyses. After 4 weeks, 200 nursing students were recruited to retest the reliability. The evaluation tool of TCM confidence included 6 dimensions and 25 entries.

Results
Cronbach’s α coefficient of the evaluation scale was 0.95 and that of the 6 observed aspects were higher than 0.90, and split-half reliability was 0.81. For the retest reliability, Cronbach’s α coefficient of the evaluation scale was 0.93 and that of the 6 examined aspects was all over 0.80. The index of content validity Scale Content Validity Index (S-CVI) was 0.92 and Item Content Validity Index (I-CVI) was 0.83–1.00.

Conclusions
Observed results may indicate that the designed tool can be used to assess the TCM confidence level of students with TCM studied experience and also can evaluate results of TCM education during studying TCM lectures.
Survival in Patients with Liver Cirrhosis: A Prospective Study
Authors: Ristovska Elena Curakova , Genadieva-Dimitrova Magdalena , Todorovska Beti 
Published: December 2023

Abstract

Introduction: The differences in the survival time of cirrhotic patients reported by different studies are probably caused by the influence of many contributing factors. The aim of the study was to evaluate the survival over a one-year period, to register the occurrence of acute decompensation (AD) and to determine the most frequent causes of death.

Material and methods: Out of 71 patients enrolled in the study, 63 completed the prospective one-year follow-up. During the follow-up, we evaluated the occurrence of AD, the causes of death, and we registered three-month, six-month and one-year survival regarding the AD status at presentation.

Results: Of the 63 patients, 24 (38.09%) died before the end of the study (14 patients before the end of three months, 6 before the end of six months and 4 patients before the end of one year). The overall survival was 38.09% and the mean survival time was 108 ± 98.53 days. The most prevalent cause of death was bleeding from esophageal varices (5 patients, 20.83%). AD patients had a significantly shorter survival than patients without AD (97±90.54 vs. 229±138.59) and 78.57% of them died during the follow-up. The estimated six-month and one-year median survival time were 272.8 [95% CI (238.4–307.2)] and 267.1 [95% CI (232.9–301.2)] days, respectively. The six-month and one-year survival were significantly shorter in AD patients (p<0.0001).

Conclusion: The etiology, stage of liver disease and the presence of AD are important factors that influence on the survival in cirrhotic patients.
Renal functional outcomes after robot-assisted partial nephrectomy and percutaneous cryoablation of clinical T1 renal cell carcinoma – A prospective study
Authors: Duus Louise Aarup , Junker Theresa , Rasmussen Benjamin Schnack Brandt , Vilstrup Mie Holm , Lund Lars , Pedersen Michael , Graumann Ole 
Published: December 2023

Objectives:
The objective of this study was to investigate renal function after robot-assisted partial nephrectomy (RAPN) and percutaneous cryoablation (PCA) in clinical stage T1 (cT1) renal cell carcinoma (RCC) and evaluate the relationship between baseline renal function and renal functional outcome.

Material and Methods:
Patients with cT1 RCC treated with RAPN or PCA were prospectively enrolled between June 2019 and January 2021. Renal function was evaluated using estimated glomerular filtration rate, Tc-99m diethylenetriamine-pentaacetate plasma clearance, Tc-99m mercaptoacetyltriglycine renography, and renal volume at baseline and 6 months after treatment.

Results:
Fifty-six patients were included (18 RAPN, 38 PCA). PCA patients had a significantly higher age (68.5 years; P = 0.019) and Charlson comorbidity index (3.0; P = 0.007). Tumor characteristics did not differ significantly between RAPN and PCA. Total renal volume decreased significantly after PCA (−18.2 cm3; P = 0.001). Baseline chronic disease stage IIIb–IV leads to a greater reduction in renal volume (−31.8 cm3; P = 0.003) but not other renal function measures. Renal function declined significantly after either treatment without significant differences between RAPN and PCA.

Conclusion:
This study found a small, similar decrease in renal function 6 months after RAPN or PCA, despite significant differences in baseline patient characteristics. Reduced renal function at baseline did not lead to a worse renal functional outcome.
NOVAS PERSPECTIVAS DO CONSTITUCIONALISMO GLOBAL: A CONSTITUIÇÃO DA TERRA
Authors: Marques Júnior William Paiva 
Published: December 2023

As transformações são bastante perceptíveis com o quadro pandêmico mundial causado pela Covid-19, verificando-se uma reorganização do Direito Internacional. Tem-se, portanto, uma genuína internacionalização do Direito, surgindo a necessidade de reconstrução do constitucionalismo global nos tempos vivenciados como combate aos efeitos deletérios oriundos pela pandemia de Covid-19. Considerando as mutações analisadas, Luigi Ferrajoli propõe um projeto de constitucionalismo expandido para o plano internacional, elaborado para suplantar as Constituições dos estados nacionais. O autor sustenta que os direitos fundamentais devem ser universais e que a Organização das Nações Unidas fracassou em promovê-los, tal qual se vê na Guerra Rússia/Ucrânia. Utiliza-se, como metodologia, de pesquisa do tipo bibliográfica por meio da análise de livros, artigos jurídicos, documentos internacionais, da legislação e da jurisprudência, apoiando-se principalmente na obra de Luigi Ferrajoli. A pesquisa é pura, de natureza qualitativa e quantitativa, com finalidade descritiva e exploratória.
SISTEMA DE DESESTÍMULO À LITIGÂNCIA POR MEIO DOS PRECEDENTES GARANTINDO O PRINCÍPIO DA PROCEDIMENTALIZAÇÃO DA ISONOMIA
Authors: Mansano Josyane , Mollica Rogerio 
Published: December 2023

O Código de Processo Civil (Lei nº 13.105, de 16 de março de 2015) em muito inovou a metodotização dos procedentes estabelecidos pelas Cortes Superiores e Tribunais locais, objetivando outorgar mais racionalidade ao sistema de justiça. Foram criados, neste tocante, diversos instrumentos jurídicos para a formação de precedentes qualificados, como o Incidente de Resolução de Demandas Repetitivas e Incidente de Assunção de Competência. O presente estudo propõe-se a analisar como uma abordagem centrada na formação do stare decisis pode contribuir para a criação de ambiente negocial favorável à aplicação de precedentes vinculantes a partir da doutrina do common law, favorecendo a segurança jurídica, como a principal função de garantir a isonomia nos julgamentos, vez que, no Brasil, a propensão das decisões judiciais é formar uma “corrente jurisprudencial”, o que, de certo modo, não dá uniformidade. Assim, a partir de uma perspectiva gerencial, cuja preocupação é centrada no enfrentamento dos números e nas estatísticas de julgamento que interferem no funcionamento adequado do Poder Judiciário, essa estratégia possibilita a solução de milhares de processos e a redução do acervo processual. O resultado do estudo mostrou que, tomando como referência a promessa de otimização dos precedentes há influência na consolidação do Poder Judiciário em converter segurança aos jurisdicionados, para que haja um ambiente eufônico entre os poderes do Estado.
ADMINISTRAÇÃO CONSENSUAL E CONFIANÇA PÚBLICA: O DIÁLOGO COMPETITIVO COMO FERRAMENTA DISRUPTIVA DA AQUISIÇÃO PÚBLICA TRADICIONAL
Authors: Silva Alexandre Antonio Bruno da , Brunetta Cíntia Menezes , Maia Paulo Roberto Fontenele 
Published: December 2023

A nova Lei 14.133/2021 surge em um cenário brasileiro carente de decisões transparentes e objetivas em termos de políticas públicas. Mais do que isso, ingressa no ordenamento jurídico pátrio no meio de uma pandemia que forçou uma reinterpretação e uma reinvenção de velhas e ultrapassadas práticas administrativas inspiradas em tradições seculares. O presente artigo aborda questões tão diversas como administração consensual e machine learning, legitimidade e governança, burocracia e eficiência. Pretende buscar no passado legitimidade e razão para as transformações, encontrar no presente ferramentas possíveis para elas e projetar no futuro uma administração pública mais coerente e democrática. No seu desenvolvimento, reconhece-se que pensar em modernização do Estado é pensar em burocracia e em processos decisórios transparentes. Defende-se, a seguir, que a nova modalidade licitatória trazida pela Lei 14.133/2021, o diálogo competitivo, inaugura uma Administração Pública menos encastelada e mais horizontal, institucionalizando a participação privada na busca pelas melhores soluções para os desafios da “era da informação”. Conclui-se que se está diante de uma transformação paradigmática do Direito Público, em que abandona o formalismo jurídico para uma interpretação mais realista da norma mediante a concretização da Administração Pública consensual.