bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-World Tralokinumab Use in Dupilumab-Experienced Patients: A Eetrospective Multi-Center Case Series
Authors: Herman Edward , Burgy Jessica , Shahriari Mona 
Published: January 2024

Introduction: There is a need for treatment options that offer atopic dermatitis (AD) patients long-term disease control along with a favorable safety profile. Head-to-head studies of the two available FDA-approved biologics dupilumab and tralokinumab for adults with moderate-to-severe AD have not been performed, and real-world evidence of tralokinumab use in patients that were previously treated with dupilumab is limited.
Objective: To further characterize the tralokinumab efficacy and safety profile by evaluating clinical findings in patients previously treated with dupilumab in routine clinical practice who later switched to tralokinumab.
Method: Nine adult patients with moderate-to-severe AD previously treated with dupliumab, and subsequently switched to tralokinumab, were included. Data collected during routine clinical practice related to tralokinumab treatment included duration of treatment, dose, IGA, BSA, PROs, and AEs.
Results: Median (range) baseline IGA and IGA at time of tralokinumab administration were 4 (3-4) and 3 (2-4), respectively. Median baseline BSA and BSA at time of tralokinumab administration were 20% (4-30%) and 10% (1-30%), respectively. Disease duration ranged from 1-2 years to over 20 years. Duration of dupilumab treatment was 2-8 months (n=6). Reasons for discontinuing dupilumab treatment included AEs (n=5) and inadequately controlled AD on dupilumab (n=3). All 9 dupilumab-experienced patients were administered on-label tralokinumab (every 2 weeks, n=1; every 4 weeks, n=1) and had been on tralokinumab for 2-8 months. At the time of data collection, median (range) IGA and BSA for these patients were 0 (0-3) and 0% (0-10%), respectively. All patients experienced improvements in PROs; 67% (6/9) reported improvements in itch with NRS scores of 0/1, 44% (4/9) reported general clearance of AD signs and symptoms, and 44% (4/9) reported overall satisfaction of being on tralokinumab. AEs of conjunctivitis (n=3) and joint pain (n=1) completely resolved in patients upon switching from dupilumab to tralokinumab. No AEs were reported except in 1 patient with possible mild seborrheic dermatitis/head-neck dermatitis eruption that was treated with topicals, and 1 patient with herpes labialis, which was unclear if related to tralokinumab treatment.
Conclusion: This case series suggests tralokinumab is a potentially effective therapy in moderate-to-severe AD patients who have failed dupilumab due to lack of efficacy or AEs.
Use of the 40-Gene Expression Profile (40-GEP) Test in Medicare-Eligible Patients Diagnosed with Cutaneous Squamous Cell Carcinoma (cSCC) to Guide Adjuvant Radiation Therapy (ART) Decisions Leads to a Significant Reduction in Healthcare Costs
Authors: Somani Ally‐Khan , Ibrahim Sherrif , Tassavor Michael , Yoo Jane , Farberg Aaron 
Published: January 2024

Objective: Adjuvant radiation therapy (ART) is often recommended for high-risk cSCC patients but carries significant costs and risks. This study aims to determine if utilizing the 40-GEP test to guide ART can reduce healthcare costs in cSCC management.
Methods: Medical claims data with new diagnoses of cSCC for the 12 months ending June 2022 in the Medicare (≥65 years) population (source: IQVIA claims database) were obtained and normalized to the general population for missingness. CPT codes associated with radiation therapy within one-year post diagnosis were used to establish adjuvant RT use (defined as ‘ART’). Average weighted direct costs for four major ART modalities were calculated from published studies and (IQVIA). Sensitivity analysis was used to assess the financial impact of ART treatment using varying distributions of 40-GEP Class results.
Results: Normalized medical claims data identified 22,917 Medicare-eligible cSCC patients who received ART within the United States. The weighted average direct cost for ART, which includes the four most used CPT code-defined modalities (IGRT, IMRT, IMPT, and XRT), was $60,693 per patient, amounting to an annual projected ART cost of $1.4 billion. Using the distribution of 40-GEP results from published studies, utilization of a 40-GEP test result to avoid ART in these patients could save up to $972 million in Medicare-eligible population. Sensitivity analysis shows, depending upon the distribution of the 40-GEP results, that for every 10% of Class 2A test results omitting ART, an extra $38-66 million in annual savings is expected
Limitations: Potential limitations include a need for more comprehensive patient information and the cost of ART-related complications.
Conclusion: Utilizing the 40-GEP test results to guide ART decision-making would result in material savings to Medicare.
L’art écologique selon Paul Ardenne : extensions et limites d’un genre
Authors: Mérigonde Mireille 
Published: January 2024

Chez Paul Ardenne, la définition des arts écologiques constitue, d’une part, une extension du champ de l’art, en y intégrant des pratiques culturales comme l’artisanat ou l’agriculture et, d’autre part, une limitation rigoureuse des frontières du genre dit « écologique ». Si l’on conçoit aisément, comme l’auteur, que tout Faire avec la Nature n’est pas nécessairement « écologique », il nous semble plus discutable de décréter le caractère « anesthétique » de ces pratiques artistiques. L’installation Ici, lumières sur les espèces éteintes de Cathy Connan nous permettra de montrer que, bien au contraire, toute éthique se fonde sur le sensible et que, de fait, toute création artistique emporte avec elle son esthétique.
Critical Success Factors for Quality Improvement Projects In Pasuruan, East Java, Indonesia
Authors: Matarat Korakot 
Published: January 2024

Purpose: This study aims to examine hotel reviews, with a specific emphasis on environmental aspects. Employing advanced sentiment analysis techniques, we delve into user sentiments expressed in evaluations.

Theoretical Framework: The theoretical framework utilizes sentiment analysis to delve into hotel reviews, emphasizing the environment. Focused on key areas such as staff service (professionalism and friendliness), hotel environment and facilities (beautiful décor and cleanliness), and affordability with a friendly pricing strategy.

Design/Methodology/Approach: This study involves the manual collection and analysis of 3,475 hotel review from Centara Hotel & Convention Center Udon Thani. The methodology includes systematic steps: Preprocessing (removing irrelevant charcters and stopword), Feature Extraction (identifying key elements), Classification (using Logistic Regression for binary sentiment analysis), and Prediction (applying the model to categorize new reviews).

Findings: In our findings, Logistic Regression effectively categorized reviews into positive or negative sentiments, boasting a robust macro precision of 0.80. Notably, positive evaluations showed superior prediction results, with a high recall value of 0.84 percent, contributing to an impressive overall accuracy of 86 percent. These results highlight the efficacy of Logistic Regression in distinguishing sentiment categories, affirming its suitability for this analysis.

Research, Practical & Social Implications: In summary, focusing on enhancing staff service, maintaining a pristine hotel environment, and offering friendly, affordable services has the potential to greatly boost customer satisfaction and overall business performance. These strategic efforts not only generate positive feedback but also lead to increased competitive advantages and expanded market share in the fiercely competitive hotel industry.

Originality/Value: The findings have broader implications by shaping public perceptions, providing valuable insights for strategic decision-making, and positioning hotels for success in the highly competitive hospitality landscape.
Pelilinan dan Penyimpanan Suhu Rendah pada Cabai Rawit Varietas Lokal Garut dan Ori 212
Authors: Dwi Utami Nur Usmani  , Efendi Darda , Deden Derajat Matra  , Dewi Sukma  
Published: January 2024

Cabai rawit memiliki kadar air cukup tinggi sehingga tidak dapat disimpan terlalu lama serta mudah mengalami kerusakan. Buah cabai yang sudah dipanen masih melangsungkan aktivitas fisiologis dan metabolisme sampai buah memasuki proses pembusukan. Perlu penanganan pasca panen yang dapat memperpanjang umur simpan dan mempertahankan mutu cabai rawit, diantaranya adalah dengan pelilinan menggunakan bahan yang aman dikonsumsi seperti lilin lebah, lilin karnauba, dan kitosan. Penelitian bertujuan mengetahui konsentrasi dari masing-masing bahan pelapis yang efektif memperpanjang masa simpan dan mempertahankan mutu buah dengan penyimpanan suhu rendah. Penelitian menggunakan Rancangan Acak Kelompok (RAK) faktor tunggal yaitu konsentrasi bahan pelapis. Pengamatan yang dilakukan terdiri dari pengamatan destruktif meliputi pengukuran kadar air pada awal sebelum perlakuan dan pengamatan non-destruktif meliputi pengukuran susut bobot, kualitas visual buah, kemunculan gejala penyakit, pembusukan buah, dan buah kering. Hasil penelitian menunjukkan pelilinan dikombinasikan dengan penyimpanan pada suhu rendah dapat menekan susut bobot, mempertahankan kualitas visual, serta menghambat kemunculan gejala penyakit. Cabai rawit varietas lokal garut dengan pelilinan lilin lebah 0,5%, lilin karnauba 0,5%, dan kitosan 1,5% serta cabai rawit varietas ori 212 dengan lilin lebah 0,5%, lilin karnauba 1,5%, dan kitosan 2% dengan penyimpanan suhu rendah mampu mempertahankan kualitas buah selama 30 hari.
Kata kunci: cabai rawit, pasca panen, pelilinan, penyimpanan
ANALISIS LULUSAN MATEMATIKA FMIPA UNIVERSITAS MATARAM MENGGUNAKAN DIAGRAM KONTROL MULTIVARIATE EXPONENTIALLY WEIGHTED MOVING AVERAGE (MEWMA
Authors: Ramdani Vidya Atika , Sulistyowati Emmy Dyah , Harsyiah Lisa 
Published: January 2024

Pengendalian kualitas lulusan Matematika FMIPA UNRAM tahun 2012-2018 dengan diagram kontrol Multivariate Exponentially Weighted Moving Average (MEWMA), merupakan bentuk uji yang digunakan untuk mengontrol kualitas lulusan dan mengetahui penyebab kurangnya kualitas lulusan mahasiswa Matematika. Dalam uji ini, dilakukan pengontrolan dengan menggunakan tiga variabel kontrol yaitu Indeks Prestasi Kumulatif , lama studi , dan jumlah Satuan Kredit Semester . Pada penelitian ini digunakan nilai pembobot dengan Batas Kontrol Atas (BKA) senilai 10,685. Diperoleh hasil bahwa diagram kontrol yang terbentuk menunjukkan terdapat 42 data yang berada diluar batas kontrol (out of control), hal ini menyebabkan kualitas lulusan menjadi tidak terkontrol. Dengan menggunakan diagram kontrol univariat EWMA, diketahui bahwa variabel lama studi menjadi penyebab data out of control. Oleh karena itu, dilakukan revisi pada diagram kontrol MEWMA sehingga proses pengendalian kualitas lulusan Matematika FMIPA Universitas Mataram berada dalam batas kontrol setelah revisi kedua. Hal tersebut ditunjukkan dengan tidak adanya titik pengamatan yang berada di luar batas kontrol sehingga kualitas lulusan matematika dapat dikatakan baik. Selanjutnya, dilakukan perbandingan hasil pengamatan dengan kualitas lulusan Matematika Universitas Mataram menggunakan diagram kontrol T2 Hotelling pada penelitian sebelumnya dengan hasil terdapat satu subgrup data yang keluar batas kontrol dengan 𝐵𝐾𝐴 = 14,5249 yang menyebabkan perlunya revisi diagram kontrol T2 Hotelling sebanyak satu kali revisi sehingga mendapatkan diagram yang terkontrol secara statistik. Dengan demikian, dapat dikatakan bahwa diagram kontrol MEWMA lebih sensitif dibandingkan dengan diagram kontrol T2 Hotelling.
Manajemen Program Boarding School Dalam Membentuk Karakter Religius Peserta Didik di MTs. Mu’allimin NW Anjani Lombok Timur
Authors: Efendy Dedy , Fahruddin Fahruddin , Makki Muhammad , Asrin Asrin , Sumardi Lalu 
Published: January 2024

Tujuan penelitian ini untuk mengetahui manajemen program Boarding school dalam membentuk karakter religius peserta didik. Penelitian ini menggunakan Jenis penelitian kualitatif dengan menggunakan pendekatan fenomenologi. Sumber data pada penelitian ini menggunakan sumber data primer dan data skunder. Pengumpulan data pada penelitian ini menggunakan teknik observasi, wawancara, dan dokumentasi. Analisis data melalui pengumpulan data, reduksi data, penampilan data dan penarikan kesimpulan. Pemeriksaan kabsahan data menggunakan uji creadibility, Transferbility, Defendability, dan comfirmability. Hasil penelitian menunjukkan; (1) Proses perencanaan program Boarding school berlangsung dalam bentuk forum musyawarah yang diikuti oleh yayasan, tenaga pendidik, komite madrasah, wali santri, tenaga kependidikan, dan pengurus asrama. (2) Pengorganisasian pada program Boarding school merupakan kegiatan pembagian tugas yang ditentukan secara struktural (3) Pelaksanaan program Boarding school terbagi menjadi beberapa jenis kegiatan; 1) kegiatan religius di lingkungan asrama. 2) kegiatan religius di lingkungan madrsah/sekolah. 3) pembiasaan budaya religius di lingkungan asrama dan lingkungan sekolah. (4) Pengontrolan program Boarding school di MTs Mu’allimin NW Anjani dilakukan dalam bentuk evaluasi kegiatan setiap bulan bersama pengurus program Boarding school. (5) Faktor pendukung; Fasilitas asrama dan madrasah, pengasuh tetap bersama santri, kerjasama orang tua dan guru, semangat menuntut ilmu, dan do’a serta semangat orang tua. Faktor penghambat; turunnya komitmen dari diri sendiri; tercermin dari kenakalan, kebosanan, dan kemalasan santri karena kegiatan-kegiatan terlalu padat.
Pelaksanaan Supervisi Akademik Oleh Kepala Sekolah di SMP Negeri 2 Kuripan Kabupaten Lombok Barat
Authors: Nahar Nahar , Rokhmat Joni , Sudirman Sudirman , Asrin Asrin , Makki Muhammad 
Published: January 2024

Supervisi merupakan kegiatan untuk memberikan bantuan kepada guru mengembangkan kemampuan dan keterampilannya dalam mengelola pembelajaran dan pencapaian tujuan pembelajaran. Fokus penelitian ini adalah pelaksanaan supervisi akademik oleh kepala sekolah di SMP Negeri 2 Kuripan Kabupaten Lombok Barat. Tujuan penelitian ini adalah: (1) mendeskripsikan perencanaan supervisi akademik oleh kepala sekolah di SMP Negeri 2 Kuripan Kabupaten Lombok Barat, (2) mendeskripsikan pelaksanaan supervisi akademik oleh kepala sekolah di SMP Negeri 2 Kuripan Kabupaten Lombok Barat, dan (3) mendeskripsikan tindak lanjut supervisi akademik oleh kepala sekolah di SMP Negeri 2 Kuripan Kabupaten lombok Barat. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Pengumpulan data dilakukan melalui observasi, wawancara dan dokumentasi. Subyek penelitian adalah kepala sekolah dan guru-guru di SMP Negeri 2 Kuripan. Teknik supervisi yang digunakan adalah teknik individual dan teknik kelompok. Hasil penelitian menunjukkan bahwa: (1) kepala sekolah memiliki perencanaan supervisi yang baik yaitu melaksanakan rapat persiapan, membentuk tim, menyusun rencana program supervisi, dan menyusun jadwal supervisi, (2) kepala sekolah melaksanakan supervisi akademik dengan langkah-langkah pra observasi, observasi, dan pasca observasi atau pertemuan balikan, (3) kepala sekolah melakukan tindak lanjut supervisi akademik memberikan penguatan dan penghargaan kepada guru-guru yang memenuhi standar, memberikan teguran, saran kepada guru-guru yang belum memenuhi standar, dan memberikan kesempatan guru-guru untuk mengikuti pendidikan dan latihan lebih lanjut.
Peran Beauty Influencer Dalam Meningkatkan Minat Beli Produk Make Up Pada Generasi Z
Authors: Indah Lestari Novia , Ramadani Mery , Noor Syrah Anniba , Anggreini Stevany 
Published: January 2024

In recent years, the development of commercial communications and live broadcast events on television has attracted a lot of attention from the public, especially the younger generation. Is a Trend in today’s digital world across various social media platforms, creating an opportunity for brands to market through social media influencers, many artists or athletes getting involved with the product and delivering their reviews so that many target audiences. We call beauty influencers. Currently, generation Z will tend to look at reviews from beauty influencers before they buy a product. This research aims to see the effect of beauty influencers on customer purchase intention in cosmetic products. This research on Generation Z. The sample was 100 respondents using purposive sampling. The data will be processed using regression. The results show that the role of beauty influencers can increase the purchase intentions of Generation Z partially or simultaneously and influences 87.6% and the remaining 12.4% is influenced by other variables not examined in this research.

Keywords : beauty influencer, purchase intention, gen z
Pengembangan Aparatur Desa Wangunharja Melalui Bimbingan Teknis Coaching dan Counseling
Authors: Anindita Nadiarani , Maasir Lidia , Annisa Yayuk Nur 
Published: January 2024

The aim of this coaching and counseling technical guidance activity is to enhance the competency of the Wangunharja Village Apparatus in the field of coaching & counseling. It is hoped that this activity will foster advanced village governance practices, cultivating village cadres as leaders who have good knowledge, attitudes and skills. The research used Participatory Learning and Action method. This activity is carried out by emphasizing lectures, discussions, brainstorming and simulations conducted interactively with group members, complemented by real-world actions or activities relevant to community empowerment material through coaching & counseling. The outcomes of community service activities aligned with the established plans. Village officials were receptive and enthusiastic about training workshops and exhibited tangible improvements in their knowledge, attitudes, and skills. The output of this technical guidance activity is the preparation of coaching and counseling guidelines for Wangunharja village officials.
Premature Menopause and its Association with Dyslipidemia
Authors: Gupta Sunita Kumari , Kumar Pratap , Gupta Suprita , Sah Sanjay Kumar , Marasini Surendra 
Published: January 2024

Introduction: Premature Menopause is defined as premature ovarian failure before the age of 40 years with a consecutive 12 months of amenorrhea. Menopause affects 1% of women under the age of 40 years. It is seen in 10‑28% of primary amenorrhea and 4‑18% of secondary amenorrhea. Estrogen deficiency occurring during premature menopause causes decrease in HDL level and increase in LDL, cholesterol and triglycerides levels thus causing dyslipidemia. Regardless of cause, women who experience estrogen deficiency at an early age before the natural menopause are now considered to be at increased risk for premature morbidity and mortality. The current study is aimed to find out the impact of premature menopause on the blood lipid level in the current population.
Materials and Methods: Ninety-six cases of premature menopause women were enrolled retrospectively for the study. Complete Lipid profile – Serum Total Cholesterol, Serum Triglyceride, Serum HDL, were measured in fully automated biochemistry analyzer and Serum VLDL and Serum LDL were estimated by Friedewald's Formula.
Results: The current study revealed the lipid profile status of premenopausal women. The prevalence of dyslipidemia was observed in 57 cases (59.4%) and remaining 39 cases (40.6%) were having normal lipid levels. On comparing the serum lipid levels statistical significance were observed in Total cholesterol (P value: 0.00), Triglyceride (P value: 0.00), LDL-C (P value: 0.00), and VLDL-C (P value: 0.00). However, no statistically significant difference was observed in HDL cholesterol (P value: 0.15).
Conclusions: Serum Lipid levels is deranged in the women with premature menopause (Age < 40 years) and thus dyslipidemia, particularly noticed with the Total cholesterol and triglyceride levels. The path-physiology lying behind dyslipidemia can be correlated to the premature ovarian failure and estrogen deficiency.
Specifics of perception and assessment of motor experience in the pedagogy of motor activity and physical effort
Authors: Vrzhesnevskyi Ivan , Rakitina Tatiana , Orlenko Natalia , Yanishevskyi Yuriy 
Published: January 2024

In the pedagogical tradition of physical education, such an important factor as "personal movement experience" is not sufficiently represented. Neglecting the specified influencing factor significantly reduces the effectiveness of the pedagogical process of this discipline. The author's vision of the role of a person's motor experience in the communicative field of physical education and in the formed "attitudes" of an individual towards regular physical exertion is proposed in the work. The purpose of the study is to explain the significance of the interaction of psychophysiological, pedagogical and anthropological factors of personal motor experience in the context of the perception of physical efforts, in accordance with the specifics of role communication in physical education.
The multifaceted effects of personal movement experience in the context of forming an attitude to physical education are revealed. According to the results of testing and a questionnaire survey (regarding key elements of attitude to physical education and loads) of first-year students of NAU, the following levels of the state of "motor experience" of students are proposed: "initial", "basic", "sufficient" and "sufficient plus". The specificity of the teacher's role communication is determined. Based on the results of the analysis and generalization of teaching experience, testing and questionnaires, the following sequence of acquiring a person’s motor experience was proposed: “initial”, “basic”, “sufficient”, “sufficient plus” with the provision of appropriate definitions.
Conclusions:

the lack of adequate personal motor experience calls into question at a certain stage the student’s subjectivity in the pedagogical process of physical education;
stratification of the contingent of those who engage in personal movement experience reduces the effectiveness of physical education classes;
a physical education teacher must adapt his motor experience to the general field of pedagogical practice in physical education.
Тechnologies of use of physical training means of freestyle wrestlers in adolescent age
Authors: Danko Grigory , Lavrentiev Oleksandr , Danko Taras , Krupenya Svitlana , Zhyvollovych Svitlana 
Published: January 2024

This article examines issues aimed at the development of free wrestling and the specifics of development at the teenage age. Which mainly depends on one of the most important biological factors - puberty, which begins at the age of 12-13 years. The process of puberty is accompanied by significant changes in the activity of all physiological systems, primarily the central nervous system. The initiator of puberty is the hypothalamus, which forms a single hypothalamic-pituitary system with the pituitary gland. They are not only the most important structure of the regular system of the brain, which is responsible for higher nervous and mental processes occurring in the human body, but are also the center of neuroendocrine regulation of physiological systems that ensure homeostasis. A sharp increase in the activity of the hypothalamus at the initial stage of puberty causes drastic changes in the functioning of all body systems.
Physical education and sports training are specialized forms of managing the development of a person's physical, mental abilities and properties through the development of the culture of motor activity. The content, formulated goals, tasks, tools, methods and pedagogical technologies used in the educational and training process should be selected in accordance with the age and level of training of athletes.
Special physical training is aimed at creating a special foundation, which will be necessary for effective performance of large training volumes invested in the development of special movement qualities required in a specific sport.
Today, high sports results largely depend on the level of physical fitness of those who practice, and the main role in this process is given to timely specialization in one or another area of movements.