bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using resiliency, redundancy, and representation in a Bayesian belief network to assess imperilment of riverine fishes
Authors: Dunn Corey G. , Schumann David A. , Colvin Michael E. , Sleezer Logan J. , Wagner Matthew , Jones‐Farrand D. Todd , Rivenbark Erin , McRae Sarah , Evans Kristine 
Published: January 2024

AbstractConservation prioritization frameworks are used worldwide to identify species at greatest risk of extinction and to allocate limited resources across regions, species, and populations. Conservation prioritization can be impeded by ecological knowledge gaps and data deficiency, especially in freshwater species inhabiting highly complex aquatic ecosystems. Therefore, we developed a flexible approach that calculates a species' imperilment risk based on the conservation principles of resiliency, redundancy, and representation (i.e., the “three R's”). Our approach organizes data on species traits, distributions, population connectivity, and threats within a Bayesian belief network capable of predicting resiliency and redundancy within representative ecological settings. Empirical data and expert judgment inform the model to provide robust and repeatable risk assessments for rare and data‐deficient species. The model calculates resiliency at hierarchical spatial scales from distributional trends and population strength. Redundancy is estimated from the connectivity and quantities of extant populations. Resiliency, redundancy, and species' inherent vulnerability based on species traits collectively estimate extirpation risk within each unique ecological setting. Extirpation risks across ecological settings characterize representation and are aggregated to estimate global imperilment risk. We demonstrate the model's utility with Piebald Madtom (Noturus gladiator), a species petitioned for listing under the U.S. Endangered Species Act. Our results revealed that resiliency, redundancy, and extirpation risks can vary spatially across the species' range while identifying populations where additional sampling could disproportionally reduce uncertainty in estimated global imperilment risk. Our approach could standardize and expedite conservation status assessments, identify opportunities for early management intervention of at‐risk species and populations, and strategically reduce uncertainty by focusing monitoring and research on priority information gaps.
The global incidence, mortality, and burden of uterine cancer in 2019 and correlation with SDI, tobacco, dietary risks, and metabolic risk factors: An ecological study
Authors: Mazidimoradi Afrooz , Momenimovahed Zohre , Khalajinia Zohre , Allahqoli Leila , Salehiniya Hamid , Alkatout Ibrahim 
Published: January 2024

AbstractBackground and AimEndometrial cancer (EC) is the sixth most common cancer among women worldwide. Since global studies are based on awareness of the incidence trend, mortality, geographical diversity, and level of social development and income of countries, this study was conducted to investigate the trend of uterine cancer (UC) in the world in 2019.MethodsAge‐standardized rates (ASR) of incidence, deaths, prevalence, and disability‐adjusted life years (DALYs) of UC, as well as targeted risk factors, were extracted from the Global Burden of Disease (GBD) online database 2019. Pearson correlation coefficient and SPSS 16 were used to calculate the correlation between risk factors and ASR of epidemiological indicators. Statistical significance was considered as p < 0.05.ResultsIn 2019, the age‐specific incidence and death rate of UC was peaking at 60–64 and 65–69 years, respectively. The highest age‐standardized incidence rate per 100,000 people for UC has been reported in the Northern Mariana Islands, high sociodemographic index (SDI) countries, World Bank High‐Income category, Europe continent and among World Health Organization (WHO) regions were found in the European Region. The highest age‐standardized death rate per 100,000 people for UC has been reported in Grenada, high SDI countries, the World Bank High‐Income category, Europe continent, and among WHO regions found in the European Region. In 2019, the age‐standardized DALYs rate was 53.54 per 100,000 inhabitants, of which 48.49 cases were related to years of life lost (YLLs) and 5.05 cases were related to years lived with disability.ConclusionAccording to GBD‐2019, the highest incidence, mortality, and DALY of UC are in Europe. The evidence and traces of diversity can be seen in the inequalities of UC. Race, ethnicity, economic status, level of education and awareness, co‐morbidities, access, grade, and histological type of tumor are the most important causes of this inequality.
Knowledge, perceptions, and attitudes toward pharmacogenomics among pharmacists and pharmacy students: A systematic review
Authors: Wondrasek Amanda , Fryza Amber , Aziz Md. Abdul , Leong Christine , Kowalec Kaarina , Maruf Abdullah Al 
Published: January 2024

AbstractBackground and AimsPharmacists have been recognized as one of the most qualified healthcare professionals in the clinical implementation of pharmacogenomics, yet its widespread implementation in clinical pharmacy practice has remained limited. The review aims to systematically investigate knowledge, perceptions, and attitudes toward pharmacogenomics among pharmacists and pharmacy students to inform the future delivery of pharmacogenomics education programs.MethodsPubMed, MEDLINE, Embase, Scopus, and the International Pharmaceutical Abstracts were searched up to May 17, 2022. Studies were selected if they included data on pharmacists' or pharmacy students' knowledge, perception, or attitude about pharmacogenomics and were published in a peer‐reviewed, English‐language journal with full‐text availability. Any published study not deemed original research was excluded. All included studies were critically appraised using the Center for Evidence‐Based Management's critical appraisal tools. The data were descriptively analyzed and presented based on pharmacists' and pharmacy students' knowledge/awareness, perception/attitudes toward pharmacogenomic (PGx), confidence in using or interpreting PGx testing results, and their desire to get further PGx education or their most preferred method of further education.ResultsA combined total of 12,430 pharmacists and pharmacy students from 26 countries are represented in the 52 included studies. Despite overwhelmingly positive attitudes and perceptions toward pharmacogenomics among pharmacists and pharmacy students, an overall lack of adequate knowledge and confidence was found. The review also found a strong desire for further pharmacogenomics education among pharmacists and pharmacy students.ConclusionPharmacists and pharmacy students have positive perceptions and attitudes toward pharmacogenomics, which is hindered by a lack of knowledge and confidence. However, inadequate control for confounders, limited representativeness of the studied population or region, and small sample sizes diminish the generalizability of the review results. Knowledge and confidence could be improved through enhanced delivery of pharmacogenomic courses within the pharmacy curriculum and continuing education programs.
Water generation through desiccant using novel‐designed solar still coupled with heat pipe vacuum tube collector: An experimental observation
Authors: Srivastava Rahul , M. Chandrashekara , Yadav Avadhesh 
Published: January 2024

AbstractIn this article, an experiment has been carried out with heat pipe vacuum or evacuated tube collector to produce water from atmospheric air. In this experiment, the regeneration and adsorption method has been adopted, that is, water has been produced through the adsorption and regeneration of desiccants. The desiccant is heated through a hot surface to facilitate its regeneration. Limited experiments have been conducted to obtain water through the regeneration of desiccant using a hot surface. For the condensation of water vapor, a novel box has been designed, named the “novel‐designed acrylic box.” The water is collected in a measuring flask or beaker to determine its quantity. Silica gel desiccant has been used for the adsorption and regeneration of water vapors. In this experiment, the adsorption process for silica gel was carried out in two different ways. In the first method, 1 kg of silica gel was scattered on the copper tray, that is, inside the system, while in the second method, 1 kg of silica gel was scattered on the paper, that is, outside of the system. In the first case silica gel adsorbed 137 g water vapor, and in the second case, it adsorbed 232 g water vapor. In the first case of adsorption, 70 mL water was produced while in the second case of adsorption, 175 mL water was produced from ambient air. The system's maximum efficiency was found to be 4.9%. Effects of various parameters, such as solar intensity, ambient temperature, wind speed, and so forth, have been studied.
Cordyceps cicadae ameliorates inflammatory responses, oxidative stress, and fibrosis by targeting the PI3K/mTOR‐mediated autophagy pathway in the renal of MRL/lpr mice
Authors: Yang Feng , Zhang Yanyan , Dong Lei , Song Zhichao 
Published: January 2024

AbstractBackgroundThe vast majority of systemic lupus erythematosus patients develop lupus nephritis (LN) with severe renal manifestations, such as inflammatory responses, oxidative stress, and fibrosis. The purpose of this research was to investigate Cordyceps cicadae as a potential therapeutic target for treating inflammatory responses, oxidative stress, and fibrosis in LN.MethodsThe effects of C. cicadae on lupus symptoms in mice with LN were determined. MRL/lpr mice were treated with C. cicadae (4 g/kg/day, i.e., CC group, n = 8) or an equal volume of saline (model group, n = 8), and MRL/MP mice were treated with an equal volume of saline (control group, n = 8). Renal function indices, renal pathology, inflammatory markers, oxidative stress markers, and renal interstitial fibrosis levels were evaluated after C. cicadae treatment. Western blot analysis was performed to investigate the effect of C. cicadae on the expression of fibrosis biomarkers and the phosphatidylinositol 3‐kinase (PI3K)/mammalian target of rapamycin (mTOR)‐mediated autophagy pathway in the renal tissues of mice.ResultsC. cicadae ameliorated renal lesions, the inflammatory response, and oxidative stress damage in MRL/lpr mice. C. cicadae treatment inhibited renal fibrosis (16.31 ± 4.16 vs. 31.25 ± 5.61) and downregulated the expression of the fibrosis biomarkers alpha‐smooth muscle actin, fibronectin, and collagen I (COL I) in the kidneys of MRL/lpr mice. In addition, further research showed that the PI3K/mTOR‐mediated autophagy pathway was involved in C. cicadae‐mediated effects on renal fibrosis in MRL/lpr mice. Furthermore, the therapeutic effect of C. cicadae on repairing renal fibrosis and damage in MRL/lpr mice was abolished by the PI3K agonist 740 Y‐P.ConclusionsThe findings of the present research showed that C. cicadae could alleviate inflammatory responses, oxidative stress, and fibrosis in the renal tissues of mice with LN by targeting the PI3K/mTOR‐mediated autophagy pathway.
An innovative educational program for adolescents on home parenteral nutrition for the “transition” to adulthood
Authors: Goulet Olivier , Payen Elise , Talbotec Cécile , Poisson Catherine , Rocha Amelia , Brion Karina , Madras Marie‐Bernadette , Eicher Isabelle , Martinez Isabelle , Bégo Clémence , Chasport Céline , Ollivier Julie , Godot Cécile , Villain Claude , Joly Francisca , Lambe Cécile 
Published: January 2024

AbstractFacing with an increasing demand for transition to adult care management, our home parenteral nutrition (HPN) team designed an adolescent therapeutic educational program (ATEP) specifically intended for adolescents on long‐term HPN. The aim of this study was to report on the first sessions of this program.MethodsThe ATEP is designed in three sessions of five consecutive days, during school holidays over the year. It includes group sessions on catheter handling, disconnecting and connecting the PN and catheter dressing, dealing with unforeseen events (e.g., fever or catheter injury), but also sessions with psychologist, social worker, sports teacher, fashion specialist, meeting with adults who received HPN since childhood. Specific course for the accompanying parents were also provided. Six months after the last session, a 3‐day trip to the attraction park “le Futuroscope,” Poitiers, France, was organized without any parental presence.ResultsAfter 3 ATEP courses, a total of 16 adolescents have been enrolled. They were aged between 13 and 17 years (median 14 IQR: 14–16.25). All were on long term HPN started during the neonatal period except for four who started PN at a median age of 10 years old (IQR: 1–10). At the time of the ATEP, their median PNDI was 105% (IQR: 95.5–120.8) while receiving a median of six infusions per week (IQR: 5–7). Thirteen received Taurolidine lock procedure. After the ATEP, 11 adolescents could be considered as fully autonomous, 4 as partially autonomous and one failed to gain any autonomy. Course evaluation by adolescents or parents was good to excellent.ConclusionThrough the holistic and multiprofessional approach of this training and the group cohesion, the adolescents were not only able to handle catheter care and PN connections but were able to understand and accept better their illness and project themselves into their own future.
Congenital mixed hiatal hernia: A case report of an atypical cause of neonatal vomiting
Authors: Estrada‐Medrano Katia N. , Fernández‐Ortiz Sergio J. , Tamez‐Rivera Oscar , Villarreal Enrique G. 
Published: January 2024

AbstractCongenital mixed hiatal hernia is a disorder that combines features of both sliding and paraoesophageal hernias. The precise incidence of congenital mixed hiatal hernia during the pediatric and neonatal period remains uncertain, making diagnosis challenging within this age cohort. This case presents a 15‐day‐old female with an 8% postnatal weight loss and apost‐feeding vomiting. An upper gastrointestinal series, computer tomography, and upper endoscopy revealed a mixed hiatal hernia. The patient underwent a laparoscopic herniorrhaphy and Nissen fundoplication achieving successful resumption of complete oral feeding before discharge. Diagnosis and management of this condition in neonates remain challenging due to its rarity and variable clinical presentations. This report emphasizes the importance of early recognition, accurate diagnosis, and tailored management strategies in the neonatal period. Further research, with a collaborative effort between pediatricians and surgeons, is needed to refine diagnostic criteria, establish evidence‐based management approaches, and improve outcomes for affected children.
High rates of return to sport following management of osteochondritis dissecans of the femoral trochlea: A systematic review
Authors: Vivekanantha Prushoth , Sritharan Praveen , Hemstock Riley , Johnson Jansen , de SA Darren 
Published: January 2024

AbstractPurposeTo summarize management strategies and associated clinical outcomes in patients with osteochondritis dissecans (OCD) of the femoral trochlea.MethodsThree databases were searched from inception to 2 October 2023, for studies describing outcomes posttreatment for femoral trochlear OCD. The authors adhered to the preferred reporting items for systematic reviews and meta‐analyses and revised assessment of multiple systematic reviews guidelines as well as the Cochrane Handbook for Systematic Reviews of Interventions. Data on demographics, injury characteristics, and operative details were extracted. Outcomes included patient reported outcome measures (PROMs), complications, and revision and return to sport (RTS) rates.ResultsTwenty studies comprising 105 patients (119 knees) were included. Females comprised 10.1% (range: 0%–100%) of patients and the mean age of patients was 14.5 (range: 11–28) years. A total of 89 (74.7%) of knees received operative management, with 28 of 34 (82.4%) known open procedures being open reduction internal fixation (ORIF), and nine of 29 (31%) known arthroscopic procedures receiving arthroscopic reduction internal fixation (ARIF) or drilling. Lysholm and International Knee Documentation Committee scores in 20 patients each ranged from 93.4 to 100 and 74.7 to 96.6, respectively. The revision rate for operative procedures was 9.0%, and the overall RTS rate was 93.3%.ConclusionThere is very little high quality evidence investigating patients with femoral trochlear OCD lesions. Drilling, ARIF, and ORIF were the most common surgical options for this patient population. Patients treated with either nonoperative or operative management returned to sport at a high rate, and those requiring operative management had a low revision rate.Level of EvidenceLevel V.
No differences in long‐term clinical outcomes and survival rate of navigation‐assisted versus conventional primary mobile‐bearing total knee arthroplasty: A minimum 10‐year follow‐up
Authors: Lee Sung‐Sahn , Chang Moon Jong , Cho Jin‐Ho , Oh Juyong , Moon Young‐Wan 
Published: January 2024

AbstractPurposeThis study aimed to compare long‐term clinical and radiographic outcomes and survival rates between navigation‐assisted (NAV) total knee arthroplasty (TKA) and conventional (CON) TKA using a mobile‐bearing insert.MethodsFrom May 2008 to December 2009, 45 and 63 mobile‐bearing TKA patients were enroled in the CON‐ and NAV‐TKA groups with 146.8 months follow‐up, respectively. Clinical outcomes (Western Ontario and McMaster University Osteoarthritis Index and Knee Society Scores), radiographic outcomes (hip‐knee‐ankle [HKA], lateral distal femoral, medial proximal tibial, γ, and δ angles), and survivorship were compared between both groups.ResultsThe number of HKA angle outliers (more than 3 degrees or less than −3 degree) was significantly lower in the NAV‐TKA group (24.4% vs. 9.5%, p = 0.036) than in the CON‐TKA group. However, long‐term clinical outcomes were similar between both groups. The cumulative survival rate (best‐case scenario) was 98.3% in the CON‐TKA group and 97.5% in the NAV‐TKA group, with no significant difference between the groups (p = 0.883).ConclusionLong‐term clinical outcomes and survival rates were similar between the two groups despite fewer outliers of postoperative lower‐limb alignment in the NAV‐TKA group. Excellent survival rates were observed in both groups using mobile‐bearing inserts.Level of EvidenceLevel IV, case series.
Cystic ovary disease (COD) alters structure and function of the bovine oviduct
Authors: Scully Deirdre , Reese Sven , Kölle Sabine 
Published: January 2024

AbstractCystic ovary disease (COD) is a common cause of subfertility in dairy cattle. Therefore, the aim of this study was to provide novel concepts for cyst classification and to investigate the effects of COD on tubal microarchitecture, oviductal metabolic function, and the formation of the sperm reservoir. Bovine Fallopian tubes affected by follicular cysts, follicular cysts with luteinization and luteal cysts were investigated by a variety of microscopic and histological techniques and compared to control cows in metestrus and diestrus. We defined three types of cysts involved in COD, each of which had a characteristic wall thickness, inner wall appearance and cellular pattern within the cyst aspirate. Regarding the Fallopian tube, each cyst type was associated with a characteristic morphology, specifically the microarchitecture of the folds in ampulla, epithelial cell ratios, and ciliated/secretory cell size and form. Furthermore, each cyst type showed different patterns of tubal glycoprotein and acidic mucopolysaccharide synthesis, which was highly variable as compared to the controls. Our studies are the first to characterize the effects of COD on the Fallopian tube, which promotes the establishment of novel, cyst‐specific therapeutic concepts in cattle and helps gain a holistic view of the causes of subfertility in cows with COD.
The cost of lifelong LUTS—A systematic literature review
Authors: Holm‐Larsen Tove , Van den Ende Mauro , Wendelboe Helena Goldstein , Verbakel Irina , Kheir George Bou , Hervé François , Everaert Karel 
Published: January 2024

AbstractBackgroundLower urinary tract symptoms (LUTS) are highly prevalent and very bothersome. To support the best possible allocation of health care resources and to avoid unnecessary expenditures, it is important to understand and quantify the wide‐ranging health care costs affecting people suffering from LUTS. We aimed at creating a foundation for exploring the cost of LUTS.MethodIn this systematic literature review, we explored the costs of illness of the LUTS umbrella. We used the online literature review tool Silvi.ai for transparent decision‐making and literature management.ResultsA total of 1821 original articles were screened. Forty had explored the cost of illness of a LUTS disease since 2013. The studies were conducted in 18 countries. A number of different study designs were applied, including both retrospective and prospective studies. In total, seven LUTS indications were explored. None of them focused on lifelong LUTS. None of them were conducted in infants or children. Eighty‐two percent were conducted in adults and 18% in frail elderly. Most cost of illness studies focused on the cost of hospitalization and use of medicine.ConclusionWe have created the groundwork for understanding the cost of LUTS illness. To fully understand the cost of illness of lifelong LUTS, the main gap in research is to investigate the cost of LUTS in infants and children.
Validation of a simple body map to measure widespread pain in urologic chronic pelvic pain syndrome: A MAPP Research Network study
Authors: Clemens J. Quentin , Locke Kenneth , Landis J. Richard , Kreder Karl , Rodriguez Larissa V. , Yang Claire C. , Tu Frank F. , Harte Steven E. , Schrepf Andrew , Farrar John T. , Sutcliffe Siobhan , Naliboff Bruce D. , Williams David A. , Afari Niloofar , Spitznagle Theresa , Taple Bayley J. , Lai H. Henry ,   Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
Published: January 2024

AbstractPurposeIn patients with urologic chronic pelvic pain syndrome (UCPPS), the presence of widespread pain appears to identify a distinct phenotype, with a different symptom trajectory and potentially different response to treatment than patients with pelvic pain only.Materials and MethodsA 76‐site body map was administered four times, at weekly intervals, to 568 male and female UCPPS participants in the MAPP Network protocol. The 76 sites were classified into 13 regions (1 pelvic region and 12 nonpelvic regions). The degree of widespread pain was scored from 0 to 12 based on the number of reported nonpelvic pain regions. This continuous body map score was regressed over other measures of widespread pain, with UCPPS symptom severity, and with psychosocial variables to measure level of association. These models were repeated using an updated body map score (0–12) that incorporated a threshold of pain ≥ 4 at each site.ResultsBody map scores showed limited variability over the 4 weekly assessments, indicating that a single baseline assessment was sufficient. The widespread pain score correlated highly with other measures of widespread pain and correlated with worsened UCPPS symptom severity and psychosocial functioning. Incorporating a pain severity threshold ≥4 resulted in only marginal increases in these correlations.ConclusionsThese results support the use of this 13‐region body map in the baseline clinical assessment of UCPPS patients. It provides reliable data about the presence of widespread pain and does not require measurement of pain severity, making it relatively simple to use for clinical purposes.