bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of continuous grafting on the growth and selenium accumulation characteristics in the post-generations of tomato
Authors: Huang Zhi , Song Xiaoli , Meng Shiling , Zhou Wende , Huang Juan , Zhao Yatian , Tang Yi , Sun Bo , Li Huanxiu 
Published: October 2023

Abstract

To clarify the effect of continuous grafting on selenium (Se) uptake using tamarillo as rootstocks and tomato seedlings as scions, a pot experiment was used to study the physiological and selenium accumulation characteristics of progeny seedlings produced by continuous grafting in 10 mg kg− 1 soil. The results indicated that multiple grafting improved the biomass and soluble protein content of post-grafting generation. Chlorophyll a, b, and carotenoids were significantly increased by different numbers of grafting. In addition, POD and CAT activities increased with the number of grafting, but SOD activity decreased. Furthermore, the selenium content in the root significantly increased with the grafting treatments, with increases of 66.43% in the triple grafting, compared to the control. Moreover, the triple grafting treatment resulted in relatively high selenium accumulation in the root and aboveground parts, with increases of 74.48% and 14.29% compared to the control, respectively, which was beneficial for selenium accumulation in the progeny of grafted plants. However, the translocation coefficient decreased, inhibiting the transfer of selenium to the aboveground parts to some extent.
Inherently integrated microfiber-based flexible proprioceptive sensor for feedback-controlled soft actuators
Authors: Lee Jaehong , Kim Hwajoong , Na Hyunbin , Noh Seungbeom , Chang Shinwon , Kim Jinho , Gong Taejune , Shin Gyowook , Lee Chankyu , Lee Seonggyu , Park Yong-Lae , Oh Sehoon 
Published: October 2023

Abstract
For the accurate and continuous control of soft actuators in dynamic environments, the movements of the soft actuators must be monitored in real-time. To this end, various soft actuators capable of self-monitoring have been developed by separately integrating sensing devices into actuators. However, integrating such heterogeneous sensing components into soft actuators results in structural complexity, high manufacturing costs, and poor interfacial stability. Here, we report on intelligent pneumatic fiber-reinforced soft actuators with an inherent flexible proprioceptive sensor that uses only the essential components of typical fiber-reinforced soft actuators. The inherent flexible proprioceptive sensor is achieved by leveraging two parallel conductive microfibers around an elastomeric chamber of the soft actuator, which simultaneously acts as both a capacitive bending sensor and radial expansion limiting fibers of typical fiber-reinforced soft actuators. The proprioceptive soft actuator exhibits excellent mechanical actuation up to 240° bending motion and proprioceptive sensing performance with high sensitivity of 1.2 pF/rad. Mathematical analysis and simulations of the soft actuator can effectively predict the bending actuation and capacitive responses against input pressures. We demonstrate that proprioceptive soft actuators can be used to construct a soft gripping system and prosthetic hand which express various hand gestures and perform dexterous manipulation with real-time proprioceptive sensing capability.
Role of PGPB in phytoremediation of heavy metal contaminated soils and the biochemical responses of Vicia faba-soil system
Authors: Saadani Omar , Abdelkrim Souhir , Taamali Wael , Challougui Imen Fatnassia , Mannai Khedhiri , Jebara Moez , Jebara Salwa Harzalli 
Published: October 2023

Abstract

Phytoremediation is an eco-friendly and promising strategy for heavy metal (HM) removal from polluted soils. The present study focuses on assessing the potential of faba bean - plant growth promoting bacteria (PGPB) symbiosis in phytoremediation and soil fertility restoration. Vicia faba L. var. minor was inoculated with efficient and HMs resistant PGPB, and was cultivated in three soil samples differently contaminated by HMs; through the addition of different concentrations of copper (Cu), zinc (Zn), lead (Pb) and cadmium (Cd).An increase in shoot dry weight (SDW) and nodule dry weight (NDW) was observed after bacterial inoculation mostly in C1 soil. Furthermore, the inoculation effect was marked in the moderately contaminated soil, where a significant increase in shoots Zn, Pb and Cd accumulation (by 56%, 66% and 441, respectively). Likewise, in C1, Cu, Zn, Pb and Cd content in plants was more pronounced in inoculated V. faba by 54%, 217%, 179% and 319%, respectively, compared to the non-inoculated. Nevertheless, HMs induced a significant increase in roots antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) and inoculation further enhancing their activities essentially in C1. Moreover, PGPB considerably reduced Cu and Cd available fractions by 31% and 53%, in C1 and C2, respectively, and increased soil nitrogen (N) and phosphorus (P) content, urease and β-glucosidase activities. The obtained results highlight the effectiveness of V. faba- PGPB symbiosis in the reclamation of low and moderately Cu, Cd and Zn contaminated soils. The consortium could be used as biofertilizer to improve soil quality and fertility.
Comparative analysis of ultrastructural and metabolic changes in the transmitting tissue of Ananas comosus (L.) Merr. after various pollinations.
Authors: VIJAYAN VRINDHA , Radhamany P M 
Published: October 2023

Abstract

The study of enzyme activity during pollen development can provide an idea of the role of different enzymes in pollen tube growth and elucidate certain basic patterns and mechanisms of plant growth.The tissue-specific peroxidases in the style transmitting tissue may play a direct role in regulating pollen tube growth. Coordination between pollen and pistil is essential for successful pollination in flowering plants. A.comosus (pineapple) in Bromeliaceae prevents self-fertilization rates due to gametophytic self-incompatibility. The stigma of two commercial cultivars of Ananas was pollinated with its pollen and also pollen from other cultivar. Cross-pollinated stigma showed higher peroxidase activity compared to self-pollinated and open pollinated pistil of the flower. In peroxidase localization reddish color appeared on the stigma of cross-pollinated pistil.TEM analysis showed ultrastructural and metabolic changes in the transmitting cells of styles in Ananas after various pollinations. The cells in the transmitting tissue of Ananas is rich in cytoplasm and numerous large rough endoplasmic reticulum, large vacuole, golgi vesicles and prominent nucleus in cross-pollinated pistil.
Minimally Invasive Tibial Osteotomy and Telescopic Rod Osteosynthesis in Anterior Bowing of Osteofibrous Dysplasia of the Tibia: A Preliminary Study with a Four-Case Report, Avoiding Lesion Resection
Authors: Jing Yanhui , Zhang Zhiqiang , Mo Yueqiang , Wang Dahui , Wu Chunxing , Ning Bo 
Published: October 2023

Abstract
Background: Osteofibrous dysplasia (OFD) occurs most frequently in the tibia and may result in deformity and pathological fracture. Surgical treatment such as curettage or segment excision has been performed but remains controversial due to high complication rates and surgical burden. This study introduces a new method to manage OFD with anterior bowing of the tibia using minimally invasive tibial osteotomy and telescopic rod (TR) osteosynthesis without extensive lesion resection.
Methods: A retrospective study of 4 children with OFD and tibia bowing deformity treated with minimally invasive tibial wedge osteotomy and TR fixation between January 2015 and November 2020 was performed. Results including bone healing, complications, function based on MSTS score, and recurrance of deformity were assessed.
Results: The median follow-up was 29 months. Radiographs showed the median time for union was 3 months. There were no instances of refracture or recurrence of deformity. The mean post-operative MSTS score was significantly higher than preoperative score.
Conclusions: This method avoids large bone defects and reconstructive procedures. It is an effective and minimally invasive approach for managing anterior bowing deformity secondary to OFD while improving function and quality of life.
Level of evidence: Level IV; Case Series; Treatment Study.
Chemotherapy versus personalized therapy for EGFR mutant lung adenocarcinoma resistance to EGFR-Tyrosine Kinase Inhibitors: A Retrospective Dual-Center Study
Authors: Jiang Kan , Wu Lin , Zheng Xinlong , Xu Yiquan , Miao Qian , Zhen Xiaobing , Zhang Longfeng , Huang Cheng , Lin Gen 
Published: October 2023

Abstract
Background
Advanced lung adenocarcinoma patients often develop resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs), leaving uncertainties regarding subsequent treatment strategies. Although personalized therapy targeting individual acquired resistances (ARs) shows promise, its efficacy has not been systematically compared with platinum-containing doublet chemotherapy, a widely accepted treatment after EGFR-TKIs failure.
Methods
A retrospective dual-center study was conducted involving patients with advanced lung adenocarcinoma and EGFR mutations who developed resistance to EGFR-TKIs between January 2017 and December 2022. Eligible patients were adults aged 18 years or older with an Eastern Cooperative Oncology Group score of 0–1, normal organ function, and no prior chemotherapy. Patients were divided into the chemotherapy group (CG) or personalized therapy group (PG) based on the treatment received after disease progression. The primary endpoints were progression-free survival (PFS) and objective response rate (ORR).
Results
Of the 144 patients enrolled, there were 53 patients in the PG and 91 patients in the CG. The PG acquired resistance to EGFR-TKIs through the MET amplification and small cell lung cancer transformation and 18% of them reported multiple resistance mechanisms. The ORR of the PG was similar to that of the CG (34% vs. 33%, P = 1.0) and the PFS of the PG patients was not statistically different from that of their CG counterparts [4.2 months (95% CI: 3.6–4.8 months) vs. 5.3 months (95% CI: 4.6-6.0 months), P = 0.77].
Conclusions
These findings suggest that the therapeutic efficacy of chemotherapy approximates to that of personalized therapy, which signifies that chemotherapy is still a reliable choice for patients who develop resistance to EGFR-TKIs and that further research is awaited to explore the benefit of personalized treatment.
Financial burden of the surgical treatment for retroperitoneal sarcoma
Authors: Yokoyama Yukihiro , Sunagawa Masaki , Kurimoto Keisuke , Sakai Tomohisa , Nishida Yoshihiro , Ebata Tomoki , Kodera Yasuhiro 
Published: October 2023

Abstract
Background
The surgical treatment for retroperitoneal sarcoma (RPS) is challenging because of its complex clinical features. According to the Japanese National Health-Care Insurance System, the fee for the surgical treatment of RPS is nearly equal to that of open distal gastrectomy for gastric cancer (GC). The purpose of the present study is to compare the financial burdens of surgery for RPS and GC.
Methods
All patients who underwent surgery for GC or RPS between 2020 and 2021 at Nagoya University Hospital were included. The clinical characteristics, surgical fee per surgeon and surgical fee per hour were compared between the two groups.
Results
There were 35 patients in the GC group and 63 patients in the RPS group. In the latter, 37 patients (59%) underwent tumor resection combined with organ resection; the most common organ was the intestine (n = 23, 37%), followed by the kidney (n = 16, 25%). The mean operation time (248 vs. 417 min, p < 0.001) and intraoperative blood loss (423 vs. 1123 ml, p < 0.001) were significantly greater in the RPS group than in the GC group. The mean surgical fee per surgeon was 1,667 dollars in the GC group and 1,022 dollars in the RPS group (p < 0.001); that per hour was 1,388 dollars and 777 dollars, respectively (p < 0.001).
Conclusions
The financial burden of surgical treatment for RPS was unexpectedly higher than that for GC. Additional data are needed to determine the actual costs of RPS treatment and to justify the fee for the surgical treatment of RPS.
Time-Cost and Safety Trade-off in Project Scheduling under Uncertainty
Authors: Nasrolahi Fatemeh , Shahsavari-Pour Nasser 
Published: October 2023

Abstract
The aim of this study is to find a balance between cost, time, and fuzzy safety constraints in project scheduling. The objective is to minimize both the duration and the cost of the project while maintaining the safety standards within acceptable limits. Appropriate attention to safety can lead to increased customer satisfaction. By optimizing significant objectives such as cost and time, along with other project objectives like safety, project managers can deliver superior-quality projects. The existence of multiple factors that could potentially jeopardize project safety significantly impacts initial managerial estimates, and unforeseen changes may arise. Thus, it is crucial to consider the impact of safety on project scheduling, particularly when juggling multiple project objectives. Most real-world optimization problems are more complex and challenging to solve than those solvable through exact methods. Metaheuristic algorithms are typically employed to address NP-hard problems. In this study, we utilize the NHGA metaheuristic algorithm, proving to be more efficient than the classic genetic algorithm. As safety factors in project realms are often uncertain, we employ fuzzy number theory and linguistic variables to measure safety and account for the project manager's risk tolerance.
Symptom Clusters and Influencing Factors in Elderly Patients on Maintenance Hemodialysis
Authors: Weng JiaMin , Lu ChuHan , Huang BiHong , Chen Jing , Yang XiaoLi , Wang MengJing 
Published: October 2023

Abstract

Background
Symptom clusters can provide empirical evidence for the development of personalized and accurate symptom management strategies. This study aimed to investigate symptom clusters in elderly patients on maintenance hemodialysis, and to explore factors influencing symptom clusters.
Methods
We conducted a cross-sectional study at the Huashan Hospital Hemodialysis Center. A total of 171 maintenance hemodialysis patients were enrolled. We noted demographic characteristics and collected biochemical indicators. Symptom presence and distress ratings were assessed using the Dialysis Symptom Index (DSI). Factor analyses and latent profile analyses were used, respectively, to explore symptom clusters and differing levels of distress. Binary logistic regression was used to explore risk factors associated with differing levels of distress in symptom clusters.
Results
The mean (± SD) age of participants in our cohort was 69.10±8.06 years, and 57.9% of patients were male. Six symptom clusters were obtained from our exploratory factor analysis, including a “mental emotional symptom cluster”, a “dialysis insufficiency symptom cluster”, a “neuromuscular symptom cluster”, a “pulmonary-intestinal symptom cluster”, a “vegetative nerve dysfunction symptom cluster”, and a “sexual function symptom cluster”. A three-class solution demonstrated the best fit [low distress class (71.9%), moderate distress class (20.5%), and high-distress class (7.6%)]. Female sex (OR: 3.503; 95%CI:1.424, 8.617), cardiovascular disease history (OR: 3.566; 95%CI:1.470, 8.651), low BMI (OR: 2.965; 95%CI: 1.239, 7.093), high iPTH (OR: 5.559; 95%CI: 1.096, 28.207), and high β2 microglobulin (OR: 2.485; 95%CI: 1.034, 5.974) significantly predicted moderate & high-distress profiles of symptom clusters compared to the low distress profile.
Conclusion
We identified six symptom clusters, and three different levels of distress amongst those clusters, in elderly patients receiving maintenance hemodialysis. Identifying risk factors for higher symptom cluster distress profiles could help formulate accurate and effective symptom management strategies.
Knowledge, Attitudes, and Practices Regarding Monkeypox Surveillance – A Systematic Review and Meta-Analysis
Authors: Shaik Riyaz Ahamed , Ahmed Mohammed Shakil , Miraj Mohammed , Mehta Vini , Mathur Ankita , Obulareddy Vishnu Teja , Barboza Joshuan J. , Sah Sanjit , Rustagi Sarvesh , Sheran Hashem Abu , Kishore Surekha , Mohanty Aroop , Sah Ranjit 
Published: October 2023

Abstract
Background
Core elements such as emergency coordination, cooperative surveillance, community protection, safe and scalable care, countermeasures, and research have been used to direct preparedness and response operations. Among these, healthcare workers (HCWs) attitudes and knowledge regarding monkeypox (Mpox) play a crucial part in epidemic response, prevention, and readiness. We carried out a systematic review and meta-analysis to look into the knowledge, attitudes, and practices (KAP) of HCWs about Mpox surveillance and reporting.
Methods
Using Boolean operators and MeSH keywords, a thorough search was carried out across numerous databases, including PubMed, Scopus, Embase, Web of Science, CINAHL, PsycINFO, Cochrane Library, and Google Scholar. Papers reporting on KAP assessments among HCWs were included according to inclusion criteria. To ensure uniformity in data extraction, a standardized technique was used, and interrater reliability was verified. Quality assessment and meta-analysis were carried out.
Results
There was no statistically significant difference between the average mean KAP groups, according to the pooled odds ratio (ORs) for high knowledge (0.97), high altitude (1.00), and high practice (1.00) scores. High knowledge, attitude, and practice scores made up 35.6%, 32.9%, and 31.5% of the total scores, respectively. The pooled risk ratios (RRs) for high knowledge (0.98), high altitude (1.00), and high practice (1.01) scores were not significant, indicating that there was no discernible difference in KAP scores between the two groups, in line with the results of the OR analysis. Low heterogeneity was found in the examined studies overall and for each KAP category.
Conclusion
This study emphasizes the importance of addressing knowledge gaps and differences in attitudes and practices among HCWs regarding Mpox. Some HCWs showed excellent awareness and positive attitudes, whereas others lacked fundamental skills and preventative measures. The management of prospective Mpox outbreaks should be improved through the implementation of targeted educational interventions.
Analysis of Formation Mechanism of Crystal Form I in Isotactic Polybutene-1 Based on a Melting Memory Method
Authors: Zhang Ziqi , Zhang Weijia , Li Hongshu , Wen Huiying 
Published: October 2023

Abstract

In this paper, the melting memory effect generated by a new protocol of cyclic thermal treatment with form II as “seeds” on the polymorphic transformation in isotactic polybutylene-1(iPB-1) was investigated. Polar Optical Microscope (POM), wide angle X-ray diffraction (WAXD) and Fourier transform infrared spectroscopy (FTIR) were used to study the change of morphology and crystal form II→I transition during aging. Selected crystallization temperature (Tsc) and melting temperature (Tsm) were applied to generate residual nuclei of form II. The cycled and uncycled samples were analyzed to demonstrate the formation of crystal I and polymorphic transformation. The results indicate that the melting memory has a significant effect on tetragonal modification, with an increased nucleation density and an accelerated nucleation speed. The ordered chain sequences in crystal II initiated the formation of crystal nucleus of form I, which subsequently induce fast conversion and increased transition degree in the hexagonal crystal growth. Form I was found to have two formation pathways, including the transformation of the unstable crystal form II and the direct formation from residual crystal and melt, which have been rarely discussed before and may shed light on understanding of crystal formation mechanism in polymorphism polybutene-1.
Fully tunable Fabry-Pérot cavity based on MEMS Sagnac loop reflector with ultra-low static power consumption
Authors: Park Young Jae , Her Man Jae , Jeong Youngjae , Choi Dong Ju , Kim Dong Uk , Lim Min Gi , Hong Myung Seok , Gwon Hyug Su , Han Sangyoon , Yu Kyoungsik 
Published: October 2023

Abstract

The Fabry-Pérot interferometer, a fundamental component in optoelectronic systems, offers interesting applications such as sensors, lasers, and filters. In this work, we show a tunable Fabry-Pérot cCavity consisting of tunable Sagnac loop reflectors (SLR) and a phase shifter based on electrostatic microelectromechanical actuators. The fabrication process of the device is compatible with the standard wafer-level passive silicon photonics platform. The electrical power and energy consumption of the device are extremely low, measuring less than 675nW of static power, and the energy needed for tuning is below 20 pJ. This electrostatic actuation mechanism provides well-balanced, scalable pathways for efficient tuning methodologies. The extinction ratio of the continuously tunable SLR's reflectivity is larger than 20 dB. Full 2π phase shifting is achieved, and all component's actuation times are less than 25 μs.
A Systematic review and Network Meta-analysis of pharmaceutical interventions used to manage chronic pain
Authors: Shetty Ash , Delanerolle Gayathri , Cavalini Heitor , Deng Chunli , Yang Xiaojie , Boyd Amy , Fernandez Tacson , Phiri Peter , Bhaskar Arun , Shi Jian Qing 
Published: October 2023

Abstract

Background: It is estimated 1·5 billion of the global population suffer from chronic pain with prevalence increasing with demographics including age. It is suggested long-term exposure to chronic could cause further health challenges reducing people’s quality of life. Therefore, it is imperative to use effective treatment options. We explored the current pharmaceutical treatments available for chronic pain management to better understand drug efficacy and pain reduction.
Methods: A systematic methodology was developed and published in PROSPERO (CRD42021235384). Keywords of opioids, acute pain, pain management, chronic pain, opiods, NSAIDs, and analgesics were used across PubMed, Science direct, ProQuest, Web of science, Ovid Psych INFO, PROSPERO, EBSCOhost, MEDLINE, ClinicalTrials.gov and EMBASE. All randomised controlled clinical trials (RCTs), epidemiology and mixed-methods studies published in English between the 1st of January 1990 and 30th of April 2022 were included. A total of 119 studies were included. The data was synthesised using a tri-partied statistical methodology of a meta-analysis (24), pairwise meta-analysis (24) and network meta-analysis (34). Mean, median, standard deviation and confidence intervals for various pain assessments were used as the main outcomes for pre-treatment pain scores at baseline, post-treatment pain scores and pain score changes of each group.
Findings: Our meta-analysis revealed the significant reduction in chronic pain scores of patients taking NSAID versus non-steroidal opioid drugs was comparative to patients given placebo under a random effects model. Pooled evidence also indicated significant drug efficiency with Botulinum Toxin Type-A (BTX-A) and Ketamine.
Conclusion: Chronic pain is a public health problem that requires far more effective pharmaceutical interventions with minimal better side-effect profiles which will aid to develop better clinical guidelines. The importance of understanding ubiquity of pain by clinicians, policy makers, researchers and academic scholars is vital to prevent social determinant which aggravates issue.