bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Portal Use and Risk of Readmissions in Decompensated Cirrhosis: Retrospective Study
Authors: Louissaint Jeremy , Gibbs Jeffrey , Shenoy Abhishek , Cohen-Mekelburg Shirley , Lok Anna , Tapper Elliot 
Published: December 2023

Background
Patient portals are a common electronic medical record tool that allow for the asynchronous exchange of health information between patients and their health care teams. Patients can leverage patient portals to perform tasks such as viewing test results, reviewing clinical notes, and messaging their health care team. The impact of patient portal use on clinical outcomes in cirrhosis is unknown.

Objective
In this study, we evaluated the relationship between patient portal use patterns and readmissions in cirrhosis.

Methods
We identified 131 patients with decompensated cirrhosis with an index cirrhosis-related admission between May 1, 2018, and May 1, 2019. We then examined patient portal enrollment and use data during the 6-month period preceding the study period. Portal functions evaluated included sending a message, reading a message, and reading a test result. Use was categorized as active (sending a message) and passive (reading a message or test result) and was further stratified as no, moderate, or frequent use based on the frequency of portal function use compared to the mean. The primary outcomes were 90-day and overall readmissions, adjusted for age, model for end-stage liver disease–sodium, alcohol-related cirrhosis etiology, ascites, and hepatic encephalopathy. Portal functions assessed included sending a message, reading a message, and reading a result; the total number of times a portal function was performed was divided by the number of months the patient was enrolled in the patient portal during the 6-month period.

Results
The study population was 50.4% (66/131) female, with a mean age of 58 years. Enrollment in the patient portal was 63.4% (83/131), and there was no significant difference in enrollment based on clinical or demographic characteristics. For the entire cohort, 14.5% (19/131) and 22.1% (29/131) of patients were moderate and frequent active users, respectively. Of those enrolled in the patient portal, 97.6% (81/83) of patients were moderate or frequent passive users for both reading a message and reading a test result. Moderate active users had less 90-day readmissions (odds ratio 0.77, 95% CI 0.60-1.00) and overall readmissions (subdistribution hazard ratio 0.42, 95% CI 0.21-0.84), compared to nonactive users. There was no relationship between readmissions and passive use.

Conclusions
Passive use of the patient portal is very high but is not associated with the risk of readmissions in people with decompensated cirrhosis. However, moderately active use of the patient portal is associated with a reduced risk of readmissions. Further work is needed to identify possible confounders and refine key use behaviors that may be protective with regard to the risk of readmission in this population.
Key Features of Smart Medication Adherence Products: Updated Scoping Review
Authors: Faisal Sadaf , Samoth Devine , Aslam Yusra , Patel Hawa , Park SooMin , Baby Bincy , Patel Tejal 
Published: December 2023

Background
Older adults often face challenges in self-managing their medication owing to physical and cognitive limitations, complex medication regimens, and packaging of medications. Emerging smart medication dispensing and adherence products (SMAPs) offer the options of automated dispensing, tracking medication intake in real time, and reminders and notifications. A 2021 review identified 51 SMAPs owing to the rapid influx of digital technology; an update to this review is required.

Objective
This review aims to identify new products and summarize and compare the key features of SMAPs.

Methods
Gray and published literature and videos were searched using Google, YouTube, PubMed, Embase, and Scopus. The first 10 pages of Google and the first 100 results of YouTube were screened using 4 and 5 keyword searches, respectively. SMAPs were included if they were able to store and allowed for the dispensation of medications, tracked real-time medication intake data, and could automatically analyze data. Products were excluded if they were stand-alone software applications, not marketed in English, not for in-home use, or only used in clinical trials. In total, 5 researchers independently screened and extracted the data.

Results
This review identified 114 SMAPs, including 80 (70.2%) marketed and 34 (29.8%) prototypes, grouped into 15 types. Among the marketed products, 68% (54/80) were available for consumer purchase. Of these products, 26% (14/54) were available worldwide and 78% (42/54) were available in North America. There was variability in the hardware, software, data collection and management features, and cost of the products. Examples of hardware features include battery life, medication storage capacity, availability of types and number of alarms, locking features, and additional technology required for use of the product, whereas software features included reminder and notification capabilities and availability of manufacturer support. Data capture methods included the availability of sensors to record the use of the product and data-syncing capabilities with cloud storage with short-range communications. Data were accessible to users via mobile apps or web-based portals. Some SMAPs provided data security assurance with secure log-ins (use of personal identification numbers or facial recognition), whereas other SMAPs provided data through registered email addresses. Although some SMAPs were available at set prices or free of cost to end users, the cost of other products varied based on availability, shipping fees, and subscription fees.

Conclusions
An expanding market for SMAPs with features specific to at-home patient use is emerging. Health care professionals can use these features to select and suggest products that meet their patients’ unique requirements.
Efficacy of Voclosporin in Proliferative Lupus Nephritis with High Levels of Proteinuria
Authors: Menn-Josephy Hanni , Hodge Lucy S. , Birardi Vanessa , Leher Henry 
Published: December 2023

Background
In a phase 3 study of adults with active lupus nephritis, addition of voclosporin to mycophenolate mofetil (MMF) and low-dose glucocorticoids led to significant improvements in the proportion of participants achieving complete and partial renal response as well as sustained reduction in proteinuria. This analysis examined the efficacy and safety of voclosporin in a subgroup of the phase 3 study with proliferative lupus nephritis and high levels of proteinuria.

Methods
Participants were randomized to oral voclosporin (23.7 mg twice daily) or placebo for 12 months; all participants received MMF and low-dose glucocorticoids. This analysis includes participants with class III or IV (±class V) lupus nephritis and baseline urine protein–creatinine ratio (UPCR) ≥3 g/g. Efficacy end points included complete renal response (UPCR ≤0.5 g/g with stable eGFR, low-dose glucocorticoids, and no rescue medication), partial renal response (≥50% reduction from baseline UPCR), and UPCR over time. Safety outcomes were also assessed.

Results
A total of 148 participants were in the voclosporin (n=76) and control (n=72) arms. At 12 months, 34% and 11% of participants in the voclosporin and control arms, respectively, achieved a complete renal response (odds ratio, 4.43; 95% confidence interval [CI], 1.78 to >9.99; P = 0.001). A partial renal response was achieved by 65% of the voclosporin arm and 51% of the control arm at 12 months (odds ratio, 1.60; 95% CI, 0.8 to 3.20; P = 0.18). More voclosporin- than control-treated participants achieved UPCR ≤0.5 g/g (51% versus 26%), and voclosporin-treated participants met this end point significantly earlier (hazard ratio, 2.07; 95% CI, 1.19 to 3.60; P = 0.01). The incidence of adverse events was similar between the arms; mean eGFR values remained stable and within normal range in both arms.

Conclusions
Addition of voclosporin to MMF and low-dose glucocorticoids resulted in a significantly higher proportion of participants with proliferative lupus nephritis achieving complete and partial renal responses as well as earlier reductions in proteinuria, with no evidence of worsening kidney function.
Hubungan Pengetahuan Dan Sikap Remaja Putri dengan Perilaku Vulva Hygiene di Sekolah Menengah Kejuruan Swasta Keluarga Bunda Jambi
Authors: Sari Intan Puspita , Mariana Silvia , Monica Olivia Tri , Rahmah Rahmah 
Published: December 2023

Vulva Hygiene is maintaining the cleanliness of the external genital organs. The benefits of vulva hygiene are keeping the vagina clean, comfortable when traveling and to avoid the problem of vaginal discharge in teenagers. This requires good knowledge and attitude. The aim of the research is to determine the relationship between knowledge and attitudes of young women regarding vulva hygiene. This study used an crossectional. The population in this study was 34 students of the Bunda Jambi Family Private Vocational High School (SMKS) with a total sampling technique of 34 samples at the Bunda Jambi Family Vocational School. The research results showed that there was a relationship between attitude (p<.003) and knowledge (p<.023) with vulva hygiene behavior. The conclusion is that there is a relationship between attitudes and vulva hygiene behavior, and there is no relationship between adolescent girls' knowledge and vulva hygiene behavior at the Bunda Jambi Family Vocational School. For this reason, it is hoped that teenagers will implement vulva hygiene behavior correctly, so that they will achieve a sense of comfort and avoid vaginal discharge.
Abstrak
Vulva Hygiene merupakan menjaga kebersihan organ genital eksternal. Manfaat dari kebersihan vulva adalah menjaga vagina tetap bersih, nyaman saat bepergian dan untuk menghindari masalah keputihan pada remaja untuk itu dibutuhkan pengetahuan dan sikap yang baik. Tujuan penelitian yaitu untuk mengetahui hubungan pengetahuan dan sikap remaja putri tentang vulva hygiene. Penelitian ini menggunakan desain crossectional. Populasi dalam penelitian ini yaitu siswa Sekolah Menengah Kejuruan Swasta (SMKS) Keluarga Bunda Jambi sebanyak 34 orang dengan teknik pengambilan sampel total sampling sebanyak 34 sampel di SMKS keluarga bunda jambi. Hasil penelitian didapatkan adanya hubungan sikap (p<,003) dan pengetahuan (p<,023) dengan perilaku vulva hygiene. Kesimpulan yaitu terdapat hubungan antara sikap dengan prilaku vulva hygene, dan tidak hubungan pengetahuan remaja putri dengan prilaku vulva hygiene di SMKS Keluarga Bunda Jambi. Untuk itu diharapkan kepada remaja agar menerapkan perilaku vulva hygiene dengan benar, sehingga akan tercapai rasa nyaman dan terhindar dari keputihan.
Kata Kunci : Pengetahuan, Sikap , Vulva Hygiene.
Analisis Du Pont System terhadap Penilaian Kinerja Keuangan Industri Farmasi yang Terdaftar di Bursa Efek Indonesia
Authors: Yanti Ni Putu Ayu Krisna Weda , Diatmika I Putu Gede 
Published: December 2023

Abstract
The purpose of this study was to determine the financial performance of pharmaceutical companies using the Du Pont System. The method of analysis using the Du Pont System with variables namely Total Asset Turnover (TATO), Net Profit Margin (NPM), and Return On Investment (ROI). This research was conducted with a quantitative descriptive approach. The data used is secondary data in the form of financial statements, data collection techniques with literature study. The results of the study using the Du Pont System showed that one company with a Net Profit Margin variable that was above the industry average and seven companies with a Net Profit Margin variable that was below the industry average and Total Asset Turnover below the industry standard average below the industry standard. The financial performance of pharmaceutical companies during the 2019-2020 period has a value below industry standards it can be concluded that the company's efficiency in managing all assets to generate profits is not good enough. With one companies that generate a net profit and is declared good, but is not followed by the management of existing company assets.

Keywords : Du Pont System, Return On Investment, Net Profit Margin, Total Asset Turnover
Credit Risk as Moderating Effect of Minimum Capital Adequacy Requirement, Credit Distribution and Efficiency Operational to Profitability
Authors: Ni Kadek Diana Yasmini 
Published: December 2023

Abstract
This study aims to determine: (1) to determine the effect of minimum capital adequacy on profitability, (2) to determine the effect of lending on profitability, (3) to determine the effect of operational efficiency on profitability, (4) to determine the effect of capital adequacy obligations minimum on profitability moderated by credit risk, (5) to determine the effect of lending on profitability moderated by credit risk, and (6) to determine the effect of operational efficiency on profitability moderated by credit risk. To achieve the research objectives, the research design used is correlational quantitative using secondary data obtained frompublication reportbank. The population of this study were all BPDs throughout Indonesia, amounting to 31 banks. The sampling technique in this study used purposive sampling with a total sample of 25 companies. The data analysis technique used is moderated regression analysis. The results showed that (1) the minimum capital requirement has a positive effect on profitability, (2) credit distribution has a positive effect on profitability, (3) operational efficiency has a negative effect on profitability, (4) credit risk weakens the effect of the minimum capital requirement on profitability, (5) credit risk weakens the effect of lending on profitability, and (6) credit risk strengthens the effect of operational efficiency on profitability.
Keywords: minimum capital requirement, lending, operational efficiency, credit risk, profitability
PENGARUH INTELLECTUAL CAPITAL (IC) TERHADAP IMPLEMENTASI PEMBENTUKAN CADANGAN KERUGIAN PENURUNAN NILAI (CKPN) PSAK 71 DAN KESEHATAN PERUSAHAAN PERBANKAN
Authors: Sumertaputri Sinta Kumala , Devi Sunitha 
Published: December 2023

Penelitian ini mengkaji dampak intellectual capital terhadap implementasi pembentukan PSAK CKPN 71 dan tingkat kesehatan perbankan pada 44 bank yang terdaftar di Bursa Efek Indonesia (BEI). Menggunakan Resource-Based Theory sebagai kerangka teori, penelitian ini menganalisis data dari tahun 2020 dan menggunakan analisis regresi untuk menguji hubungan antara intellectual capital, penerapan PSAK CKPN 71, dan tingkat kesehatan bank. Hasil penelitian menemukan bahwa intellectual capital berdampak positif terhadap implementasi pembentukan PSAK CKPN 71. Hasil penelitian juga menemukan bahwa intellectual capital berdampak positif terhadap tingkat kesehatan perbankan yang diukur dengan indeks RGEC. Hasil penelitian menyarankan bahwa bank harus terus berinvestasi dalam pengembangan intellectual capital mereka untuk meningkatkan tingkat kesehatan dan kemampuan mereka untuk menerapkan PSAK CKPN 71 untuk memenuhi persyaratan peraturan dan menjaga stabilitas keuangan mereka, terutama selama masa ekonomi yang penuh tantangan. Namun, penelitian ini memiliki beberapa keterbatasan, termasuk ukuran sampel yang kecil, tidak mengkaji komponen spesifik intellectual capital, dan berfokus hanya pada satu sektor industri negara. Meskipun keterbatasan ini, penelitian ini berkontribusi pada literatur intellectual capital, PSAK CKPN 71, dan tingkat kesehatan bank, serta memberikan implikasi praktis bagi perbankan dan pembuat kebijakan di Indonesia.
Kata kunci: Intellectual Capital, CKPN PSAK 71, Tingkat Kesehatan Bank, RGEC
Pengaruh Keputusan Investasi, Keputusan Pendanaan, dan Profitabilitas Terhadap Nilai Perusahaan (Studi Kasus pada Sektor Transportasi dan Logisitik yang Terdaftar di Bursa Efek Indonesia Tahun 2019 - 2021)
Authors: Fidela Netha Setiani  , I Gede Putu Banu Astawa  
Published: December 2023

Adanya fenomena fluktuasi yang cenderung menurun pada indeks saham sektor transportasi dan logistik yang menjadi faktor utama penelitian terkait nilai perusahaan. Penelitian ini bertujuan untuk menguji pengaruh keputusan investasi, keputusan pendanaan, dan profitabilitas secara parsial dan simultan terhadap nilai perusahaan pada sektor transportasi dan logistik yang terdaftar di Bursa Efek Indonesia tahun 2019 – 2021. Penelitian ini merupakan penelitian kuantitatif dengan teknik analisis regresi linear berganda dengan bantuan program SPSS versi 26. Data yang digunakan dalam penelitian adalah data sekunder. Sampel ditentukan dengan teknik purposive sampling atau berdasarkan kriteria-kriteria tertentu sehingga memperoleh 51 sampel. Hasil penelitian ini menunjukkan bahwa: (1) keputusan investasi secara parsial berpengaruh positif tetapi tidak signifikan terhadap nilai perusahaan, (2) keputusan pendanaan secara parsial berpengaruh positif dan signifikan terhadap nilai perusahaan, (3) profitabilitas secara parsial berpengaruh positif dan signifikan terhadap nilai perusahaan, (4) keputusan investasi, keputusan pendanaan, dan profitabilitas secara simultan berpengaruh positif dan signifikan terhadap nilai perusahaan.
Kata kunci: keputusan investasi, keputusan pendanaan, profitabilitas, dan nilai perusahaan
CURRENT CONCEPT AND MANAGEMENT OF FEMORAL SHAFT FRACTURES
Authors: Marindratama Hasmeinda , Santoso Asep , Anwar Iwan Budiwan 
Published: December 2023

ABSTRACT
Femoral shaft fractures are severe injuries and are often associated with a high impact trauma mechanism, frequently seen in multiple injured patients. In contrast an indirect trauma mechanism can lead to a complex femoral shaft fracture especially in elderly patients with minor bone stock quality. Hence management of femoral shaft fractures is often directed by co-morbidities, additional injuries and the medical condition of the patient. Timing of fracture stabilization is depended on the overall medical condition of the patient, but definite fracture fixation can often be implemented in the early total care concept in management of multiple injured patients. Femoral shaft fractures (FSF) typically occur in a bimodal distribution, high-energy trauma in the young population, and lower energy trauma in the elderly population. FSFs are also associated with other comorbidities necessitating a thorough advanced trauma life support (ATLS) assessment and interdisciplinary care. Intramedullary nailing (IMN) is the most common treatment of physiologically stable patients. The goal of fixation is early healing and long-term functional recovery. Treatment of modern-day femoral shaft fractures results in excellent outcomes.

ABSTRAK
Fraktur Shaft Femur (FSF) merupakan cedera yang parah dan sering dikaitkan dengan mekanisme trauma high-impact, sering dijumpai pada pasien dengan cedera multipel. Sebaliknya mekanisme trauma tidak langsung dapat menyebabkan FSF yang kompleks terutama pada pasien usia lanjut dengan kualitas cadangan tulang yang minim. Oleh karena itu penatalaksanaan FSF sering disesuaikan dengan penyakit penyerta, cedera tambahan, dan kondisi medis pasien. Waktu dilakukannya stabilisasi fraktur bergantung pada kondisi medis pasien secara keseluruhan, tetapi fiksasi fraktur yang definitif sering kali dapat dilakukan dalam manajemen awal pasien dengan cedera multipel. FSF dapat terjadi pada dua kelompok usia. Pada usia muda, penyebabnya adalah trauma energy tinggi dan pada usia tua penyebabnya adalah trauma energy rendah. FSF juga dikaitkan dengan komorbiditas lain sehingga membutuhkan penilaian Advanced Trauma Life Support (ATLS) secara cermat dan perawatan interdisipliner. Intermedullary Nailing (IM) merupakan tatalaksana yang paling umum dilakukan pada penanganan pasien yang stabil secara fisiologis. Tujuan fiksasi adalah penyembuhan dini dan pemulihan fungsional jangka panjang. Pengobatan FSF masa kini memiliki hasil yang sangat baik.
Pênfigo vulgar sobre cicatrizes de mamoplastia de aumento com próteses mamárias e de abdominoplastia clássica em paciente
Authors: Canedo Lucas Ribeiro , Moura Brenner Dolis Marretto de , Lima Bárbara Matsumoto , Mendes Neto Ivam Pereira , Feitosa Damião Marcelo Pontes , Reis Carmélia Matos Santiago 
Published: December 2023

O pênfigo vulgar (PV) é uma dermatose que acomete pele e mucosas. Sua incidência é de dois novos casos/milhão de habitantes/ano na Europa Central. É conhecido por ser multifatorial e envolve interação entre predisposição genética e fatores ambientais. Este estudo relata um raro caso de PV pós cirurgia plástica. Apresentamos o caso de uma mulher de 51 anos com deiscência de sutura no pós-operatório de mamoplastia com prótese e abdominoplastia e, posteriormente, surgimento de lesões bolhosas nas cicatrizes. Essas lesões foram posteriormente diagnosticadas como PV. A paciente evoluiu com melhora das lesões após corticoterapia. Ressalta-se também que a paciente apresentou COVID-19 durante a internação, um fator conhecido de exacerbação do pênfigo, porém sem piora das lesões e com regressão completa do quadro infeccioso após tratamento. A evolução clínica do PV pode se limitar ao acometimento mucoso ou evoluir para a pele. Formam-se grandes áreas erodidas, exsudativas, sangrantes, confluentes, dolorosas e sem tendência à cicatrização. O acometimento cutâneo pode ocorrer em qualquer local, sendo mais comum no couro cabeludo, tronco, abdome e flexuras.