bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan E-Government Pada Aplikasi SIKS-NG di Desa Sihiong Kecamatan Bonatua Lunasi Kabupaten Toba
Authors: Purwanti Eka Henny 
Published: October 2023

Perkembangan teknologi ini juga sangat berpengaruh bagi sector public, secara khusus bagi jalannya roda pemerintahan di Indonesia yang kita kenal dengan e-government. Penerapan e-government merupakan salah satu cara pemerintah memberikan pelayanan yang baik kepada masyarakat dan implementasi e-government juga beragam, salah satunya dengan cara melakukan pembaruan data melalui verifikasi dan valiasi data menggunakan aplikasi Sosial Next Generation Geographic Information System (SIKS-NG). Undang-undang Nomor 13 Tahun 2011, tentang Penanganan Fakir Miskin, dan Keputusan Menteri Sosial Republik Indonesia Nomor 57/HUK/2017, tentang Penetapan Data Terpadu Program Penanganan Fakir Miskin Tahun 2017, Kabupaten/Kota di seluruh Indonesia memperoleh mandat untuk melakukan verifikasi dan validasi (verivali) data setiap tahun sekali. Verifikasi dan validasi tersebut dilakukan berdasarkan by name by address, yang ada di SIKS-NG menjadi acuan pada pelaksanaan program penanganan fakir miskin. Berdasarkan hasil penelitian yang dilakukan, bahwa implementasi aplikasi SIKS-NG dalam pemutakhiran Data Terpadu Kesejahteraan Sosial (DTKS) menghasilkan data yang sesuai dengan kondisi yang sesuai Keluarga Penerima Manfaat (KPM) di lapangan, masalah yang sering muncul dalam proses implementasi yaitu data yang berada di Aplikasi SIKS-NG berupa NIK keluarga penerima manfaat tidak sesuai dengan data di lapangan sehingga menyebabkan data tersebut tidak bersinergi , sehingga pada saat dilakukan pengusulan DTKS terjadi ketidak cocokan dan ketidak validan data dalam system aplikasi SIKS-NG. Jenis penelitian ini menggunakan pendekatan deskriptif kualitatif yang bertujuan untuk menjawab dan memecahkan gejala sosial yang terjadi dan berusaha memberikan gambaran-gambaran yang jelas tentang permasalahan objek penelitian
Back to basics: likelihood ratios for olive and grass pollen specific IgE in seasonal allergic rhinitis
Authors: Manzanares Bárbara , González Rafael , Serrano Pilar , Navas Ana , Alonso Corona , Fernandez Lourdes , Jurado Aurora , Moreno-Aguilar Carmen 
Published: October 2023

IntroductionSpecific IgE (sIgE) is merely a sensitization marker that cannot be used for allergy diagnosis if there are no associated clinical symptoms. As of 2023, there is still no evidence regarding the quantity of sIgE necessary to confirm or exclude clinical disease. Therefore, this study aimed to calculate cut-offs for sIgE, allowing us to effectively diagnose olive or grass pollen allergy and select allergenic immunotherapy (AIT) candidate patients in a region under high olive and grass allergenic pressure.MethodsAn observational retrospective study consisting of the review of electronic medical records from 1,172 patients diagnosed with seasonal rhino-conjunctivitis and suspected allergy to olive or grass pollen. Symptoms correlated with sIgE to Poaceae and Oleaceae whole extracts and sIgE to genuine allergenic components were evaluated. Optimal cut-off values were calculated using receiver operating characteristic curves. Relevant clinical symptoms and AIT indications were taken into consideration when determining the clinical allergy diagnosis.ResultssIgE to Lolium showed the best area under the curve (AUC) for both diagnosis (0.957) and an indication of AIT (0.872). The optimal cut-off values for grass diagnosis and AIT indication were 1.79 kUA/L and 8.83 kUA/L, respectively. A value of 5.62 kUA/L was associated with a positive likelihood ratio (LR) of 10.08 set for grass allergy. Olea sIgE showed the best AUC for the diagnosis (0.950). The optimal cut-off for diagnosis was 2.41 kUA/L. A value of 6.49 kUA/L was associated with a positive LR of 9.98 to confirm olive pollen allergy. In regard to immunotherapy, Ole e 1 sIgE showed the best AUC (0.860). The optimal cut-off was 14.05 kUA/L. Ole e 1 sIgE value of 4.8 kUA/L was associated with a 0.09 negative LR to exclude olive AIT indication.ConclusionsThe sIgE cut-offs found in this population under high olive and grass allergenic pressure reduce the gap between sensitization and clinical allergy, providing a new tool for the diagnosis of seasonal allergic rhinitis/asthma and helping to discriminate patients who will benefit from AIT.
Supraglacial geomorphology of Companion Glacier, central Himalaya: evolution, controls and consequences
Authors: Garg Purushottam Kumar , Mehta Manish , Shukla Aparna , Chauhan Pankaj , Kesarwani Kapil , Mukherjee Sandipan 
Published: October 2023

Supraglacial debris cover greatly influences glacier dynamics. The present study combines field and remote sensing observations acquired between 2000 and 2020 to understand debris characteristics, area and terminus changes, surface velocity, and mass balance of the Companion Glacier, Central Himalaya, along with a systematic investigation of its supraglacial morphology. According to field observations, the glacier’s lower ablation zone has very coarse and thick debris (1–3 m). Owing to thick debris and consequent protected margins, the glacier could maintain its geometry during the study (2000–2020) showing much less area loss (0.07% ±0.1% a−1) and terminus retreat (1.2 ±1.9 m a−1) than other glaciers in the study region. The average mass balance (−0.12 ±0.1 m w. e. a−1; 2000–2020) was also less negative than the regional trend. Interestingly, in contrast to widespread regional velocity reduction, Companion’s average velocity increased (by 21%) from 6.97 ±3.4 (2000/01) to 8.45 ±2.1 m a−1 (2019/20). Further, to investigate supraglacial morphology, the glacier ablation zone is divided into five zones (Zone-I to V; snout-to-up glacier) based on 100 m altitude bins. Analysis reveals that stagnation prevails over Zone-I to Zone-III, where despite slight acceleration, the velocity remains &lt;∼8 m a−1. Zone-V is quite active (12.87 ±2.1 m a−1) and has accelerated during the study. Thus, Zone-IV with stable velocity, is sandwiched between fast-moving Zone-V and slow-moving Zone-III, which led to bulging and development of mounds. Debris slides down these mounds exposing the top portion for direct melting and the meltwater accumulates behind the mounds forming small ponds. Thus, as a consequence of changing morphology, a new ablation mechanism in the form of spot-melting has dominated Zone-IV, leading to the highest negative mass balance here (−0.5 ±0.1 m w. e. a−1). The changing snout and supraglacial morphology, active mound-top’s melting and formation of ponds likely promote relatively higher glacier wastage in the future.
The relationship between sarcopenia and mortality in Chinese community-dwelling adults: a 7-year cohort study with propensity score matching and Mendelian randomization
Authors: Xiong Lijiao , Liao Tingfeng , Guo Tianting , Zeng Zhaohao , Wang Shuojia , Yang Guangyan , Wang Xiaohao , Wang Xinyu , Zhu Jing , Zhao Pengfei , Li Yanchun , Li Lixing , Kang Lin , Yang Shu , Liang Zhen 
Published: October 2023

BackgroundSarcopenia has been linked to adverse health outcomes, including an increased risk of mortality. This study aimed to assess the 7-year mortality risk of sarcopenia in a community-based population in China and explore the causal relationship between components of sarcopenia and any death.MethodsData were sourced from the China Health and Retirement Longitudinal Study (CHARLS) conducted between 2011 and 2018. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Logistic regression, Kaplan–Meier (KM) survival analysis, and propensity score matching with inverse probability of treatment weighting were used. Mendelian randomization (MR) analyses, conducted using European population data, were utilized to assess causality between sarcopenia and any death.ResultsThe study included 9,006 participants: 3,892 had no sarcopenia, 3,570 had possible sarcopenia, 1,125 had sarcopenia, and 419 had severe sarcopenia. Over 7 years of follow-up, there were 871 deaths, including 196 with sarcopenia and 133 with severe sarcopenia. The KM curves showed that sarcopenia had a higher risk of mortality. Compared to those of no sarcopenia, the odds ratios (ORs) of sarcopenia for 7-year mortality were 1.41 (95% CI, 1.06–1.87) after adjusting for confounding variables (p &lt; 0.05). The ORs of severe sarcopenia were 2.11 (95% CI, 1.51–2.95). Propensity score matching analysis and inverse probability of treatment weighting analysis confirmed these findings. The adjusted ORs of sarcopenia and 7-year mortality were 2.94 (95% CI, 1.6–5.39) in the 45–60 age group, 1.72 (95% CI, 1.11–2.68) in the 60–80 age group, and 5.03 (95% CI, 0.48–52.65) in the ≥80 age group. The ORs of severe sarcopenia and 7-year mortality were 6.92 (95% CI, 1.95–24.5) in the 45–60 age group, 2.59 (95% CI, 1.61–4.17) in the 60–80 age group, and 12.52 (95% CI, 1.18–133.18) in the ≥80 age group. The MR analyses, leveraging the inverse variance weighted (IVW) method, unveiled substantial causal links between low hand grip strength in individuals aged 60 and older, the usual walking pace, and mortality risk.ConclusionThis study underscores the significant impact of sarcopenia and its components on mortality risk within the Chinese population. Particularly, low hand grip strength and usual walking pace emerged as noteworthy contributors to mortality risk.
Skeletal muscle mass, muscle strength, and physical performance in children and adolescents with obesity
Authors: Zembura Marcela , Czepczor-Bernat Kamila , Dolibog Patrycja , Dolibog Paweł T. , Matusik Paweł 
Published: October 2023

IntroductionSarcopenic obesity (SO) is defined as obesity with low skeletal muscle function and mass. This study aimed to evaluate the presence of sarcopenic obesity according to different diagnostic criteria and assess the elements of sarcopenia in children and adolescents with obesity.MethodsA total of 95 children and adolescents with obesity (diagnosed with the use of International Obesity Task Force (IOTF) criteria) with a mean age of 12.7( ± 3) years participated in the study. Body composition was assessed with the use of bioelectrical impedance—BIA (Tanita BC480MA) and dual-energy X-ray absorptiometry—DXA (Hologic). Fat mass (FM) and appendicular skeletal muscle mass (SMMa) were expressed as kilograms (kg) and percentage (%). Muscle-to-fat ratio (MFR) was defined as SMMa divided by FM. A dynamometer was used in order to measure grip strength. Six-minute walk test (6MWT) and a timed up-and-go test (TUG) were used to assess physical performance.ResultsThe presence of SO ranged from 6.32% to 97.89%, depending on the criteria used to define sarcopenia. Children with sarcopenia, defined as a co- occurrence of low skeletal muscle mass % (SMM%) measured by DXA (≤9th centile) according to McCarthy et al. and weak handgrip strength (≤10th centile) according to Dodds et al., had significantly lower SMMa measured by both DXA and BIA, lower maximal handgrip strength, and lower physical performance. Maximal handgrip was positively correlated with SMMa (kg) and SMMa% derived from both DXA and BIA and BIA-MFR. Maximal handgrip was negatively correlated with waist-to-height ratio (WHtR). The distance of 6MWT correlated positively with BIA-measured SMMa% and BIA-MFR. 6MWT distance correlated negatively with BIA-FM% and body mass index (BMI) z-score. TUG was positively correlated with BIA-FM%, BMI z-score, WHtR, and IOTF categories and negatively correlated with BIA-SMMa% and BIA-MFR.DiscussionThe presence of sarcopenia in our study varied depending on the diagnostic criteria used. This is one of the first studies evaluating muscle mass, muscle strength, and physical performance in children and adolescents with obesity. The study highlighted the need for the implementation of a consensus statement regarding SO diagnostic criteria in children and adolescents.
Identifying potential DNA methylation markers for the detection of esophageal cancer in plasma
Authors: Pei Bing , Zhao Guodong , Geng Zhixin , Wang Yue , Wang Menglin , Wang Xiaomei , Xiong Shangmin , Zheng Minxue 
Published: October 2023

Background: Esophageal cancer (EC) is a leading cause of cancer-related deaths in China, with the 5-year survival rate reaching less than 30%, because most cases were diagnosed and treated at the advanced stage. However, there is still a lack of low-cost, efficient, and accurate non-invasive methods for the early detection of EC at present.Methods: A total of 48 EC plasma and 101 control plasma samples were collected in a training cohort from 1 January 2021 to 31 December 2021, and seven cancer-related DNA methylation markers (ELMO1, ZNF582, FAM19A4, PAX1, C13orf18, JAM3 and TERT) were tested in these samples to select potential markers. In total, 20 EC, 10 gastric cancer (GC), 10 colorectal cancer (CRC), and 20 control plasma samples were collected in a validation cohort to evaluate the two-gene panel.Results:ZNF582, FAM19A4, JAM3, or TERT methylation in plasma was shown to significantly distinguish EC and control subjects (p &lt; 0.05), and the combination of ZNF582 and FAM19A4 methylation was the two-gene panel that exhibited the best performance for the detection of EC with 60.4% sensitivity (95% CI: 45.3%–73.9%) and 83.2% specificity (95% CI: 74.1%–89.6%) in the training cohort. The performance of this two-gene panel showed no significant difference between different age and gender groups. When the two-gene panel was combined with CEA, the sensitivity for EC detection was further improved to 71.1%. In the validation cohort, the sensitivity of the two-gene panel for detecting EC, GC, and CRC was 60.0%, 30.0%, and 30.0%, respectively, with a specificity of 90.0%.Conclusion: The identified methylation marker panel provided a potential non-invasive strategy for EC detection, but further validation should be performed in more clinical centers.
An integrated machine learning predictive scheme for longitudinal laboratory data to evaluate the factors determining renal function changes in patients with different chronic kidney disease stages
Authors: Tsai Ming-Hsien , Jhou Mao-Jhen , Liu Tzu-Chi , Fang Yu-Wei , Lu Chi-Jie 
Published: October 2023

Background and objectivesChronic kidney disease (CKD) is a global health concern. This study aims to identify key factors associated with renal function changes using the proposed machine learning and important variable selection (ML&amp;IVS) scheme on longitudinal laboratory data. The goal is to predict changes in the estimated glomerular filtration rate (eGFR) in a cohort of patients with CKD stages 3–5.DesignA retrospective cohort study.Setting and participantsA total of 710 outpatients who presented with stable nondialysis-dependent CKD stages 3–5 at the Shin-Kong Wu Ho-Su Memorial Hospital Medical Center from 2016 to 2021.MethodsThis study analyzed trimonthly laboratory data including 47 indicators. The proposed scheme used stochastic gradient boosting, multivariate adaptive regression splines, random forest, eXtreme gradient boosting, and light gradient boosting machine algorithms to evaluate the important factors for predicting the results of the fourth eGFR examination, especially in patients with CKD stage 3 and those with CKD stages 4–5, with or without diabetes mellitus (DM).Main outcome measurementSubsequent eGFR level after three consecutive laboratory data assessments.ResultsOur ML&amp;IVS scheme demonstrated superior predictive capabilities and identified significant factors contributing to renal function changes in various CKD groups. The latest levels of eGFR, blood urea nitrogen (BUN), proteinuria, sodium, and systolic blood pressure as well as mean levels of eGFR, BUN, proteinuria, and triglyceride were the top 10 significantly important factors for predicting the subsequent eGFR level in patients with CKD stages 3–5. In individuals with DM, the latest levels of BUN and proteinuria, mean levels of phosphate and proteinuria, and variations in diastolic blood pressure levels emerged as important factors for predicting the decline of renal function. In individuals without DM, all phosphate patterns and latest albumin levels were found to be key factors in the advanced CKD group. Moreover, proteinuria was identified as an important factor in the CKD stage 3 group without DM and CKD stages 4–5 group with DM.ConclusionThe proposed scheme highlighted factors associated with renal function changes in different CKD conditions, offering valuable insights to physicians for raising awareness about renal function changes.
Ticks are unlikely to play a role in leprosy transmission in the Comoros (East Africa) as they do not harbour M. leprae DNA
Authors: Krausser Lena , Chauvaux Elien , Van Dyck-Lippens Magalie , Yssouf Amina , Assoumani Younoussa , Tortosa Pablo , de Jong Bouke Catherine , Braet Sofie Marijke 
Published: October 2023

IntroductionLeprosy, one of the oldest known human diseases, continues to pose a global challenge for disease control due to an incomplete understanding of its transmission pathways. Ticks have been proposed as a potential contributor in leprosy transmission due to their importance as vectors for other infectious diseases.MethodsIn 2010, a sampling of ticks residing on cattle was conducted on the islands Grande Comore, Anjouan, and Mohéli which constitute the Union of the Comoros where leprosy remains endemic. To investigate the potential role of ticks as a vector in transmission of leprosy disease, molecular analyses were conducted.ResultsOut of the 526 ticks analysed, none were found to harbour Mycobacterium leprae DNA, as determined by a quantitative polymerase chain reaction (qPCR) assay targeting a family of dispersed repeats (RLEP) specific to M. leprae.DiscussionTherefore, our results suggest that in the Union of the Comoros, ticks are an unlikely vector for M. leprae.
Study protocol of a phase II clinical trial evaluating the efficacy of neoadjuvant intraperitoneal and systemic albumin-bound paclitaxel combined with camrelizumab and S-1 in the treatment of patients with exfoliative cell-positive gastric cancer
Authors: Lv Jingxia , Wu Jiaxiang , Wu Haotian , Ding Ping’an , Guo Honghai , Yang Peigang , Tian Yuan , Liu Yang , Zhao Qun 
Published: October 2023

BackgroundCurrently, gastric cancer with positive lavage cytology without gross peritoneal dissemination (GC-CY1) is a special type of metastatic form with poor prognosis. Consensus guidelines on treatment strategies for patients with GC-CY1 have not been established. This study involves a single-arm, prospective, phase II clinical trial to examine the efficacy and safety of neoadjuvant intraperitoneal and systemic (NIPS) albumin-bound paclitaxel combined with Camrelizumab and S-1 in the treatment of GC-CY1 patients.Methods/designThis is a prospective single-center exploratory study, and the primary endpoints of the trial are R0 resection rate and conversion rate of abdominal free cancer cells (FCCs), with secondary endpoints of 3-year progression-free survival (PFS); 3-year overall survival (OS); objective remission rate (ORR); disease control rate (DCR); safety and TRG classification.DiscussionThis study is the first to apply NIPS albumin-bound paclitaxel combined with Camrelizumab and S-1 to the conversion therapy of GC-CY1 patients. It is speculated that this combination of regimens will increase the negative conversion rate of FCCs by 20%, which will provide innovative insights into conversion treatment ideas for GC-CY1 patients to be managed in a more comprehensive and optimized manner.Clinical trial registrationhttp://clinicaltrials.gov/, identifier NCT05410847.
Use and accuracy of decision support systems using artificial intelligence for tumor diseases: a systematic review and meta-analysis
Authors: Oehring Robert , Ramasetti Nikitha , Ng Sharlyn , Roller Roland , Thomas Philippe , Winter Axel , Maurer Max , Moosburner Simon , Raschzok Nathanael , Kamali Can , Pratschke Johann , Benzing Christian , Krenzien Felix 
Published: October 2023

BackgroundFor therapy planning in cancer patients multidisciplinary team meetings (MDM) are mandatory. Due to the high number of cases being discussed and significant workload of clinicians, Clinical Decision Support System (CDSS) may improve the clinical workflow.MethodsThis review and meta-analysis aims to provide an overview of the systems utilized and evaluate the correlation between a CDSS and MDM.ResultsA total of 31 studies were identified for final analysis. Analysis of different cancers shows a concordance rate (CR) of 72.7% for stage I-II and 73.4% for III-IV. For breast carcinoma, CR for stage I-II was 72.8% and for III-IV 84.1%, P≤ 0.00001. CR for colorectal carcinoma is 63% for stage I-II and 67% for III-IV, for gastric carcinoma 55% and 45%, and for lung carcinoma 85% and 83% respectively, all P&gt;0.05. Analysis of SCLC and NSCLC yields a CR of 94,3% and 82,7%, P=0.004 and for adenocarcinoma and squamous cell carcinoma in lung cancer a CR of 90% and 86%, P=0.02.ConclusionCDSS has already been implemented in clinical practice, and while the findings suggest that its use is feasible for some cancers, further research is needed to fully evaluate its effectiveness.