bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indirect treatment comparison of lanadelumab and a C1-esterase inhibitor in pediatric patients with hereditary angioedema
Authors: Watt Maureen , Goldgrub Rachel , Malmenäs Mia , Haeussler Katrin 
Published: January 2025

Aim:
To compare the efficacy and safety of lanadelumab versus other approved long-term prophylaxis (LTP) treatments in patients with pediatric hereditary angioedema (HAE) aged <12 years.
Materials
&
methods:
A systematic literature review was conducted to identify studies of LTP in patients with HAE aged <12 years. Two studies met the inclusion criteria in an indirect treatment comparison of efficacy and safety data in pediatric HAE patients. These were for lanadelumab (SPRING,
NCT04070326
) and intravenous-C1-esterase inhibitor (C1-INH[IV],
NCT02052141
). A propensity score analysis used individual patient-level data from both studies in a logistic regression model to estimate inverse probability weights. To avoid convergence issues and an underpowered analysis due to the small sample size (n = 29), the base case was defined as Poisson regression analyses on monthly attack rate adjusting for one covariate (baseline attack rate). Model selection among unadjusted, adjusted and weighted regression models was conducted through the Akaike and Bayesian Information Criteria.
Results:
Lanadelumab 150 mg every 2 weeks (Q2W) reduced the monthly HAE attack rate by 82.1% versus C1-INH(IV) 1000 IU twice weekly (every 3–4 days [BIW]; rate ratio [RR], 0.1792 [95% CI: 0.0296–1.0853]) and by 88.9% versus C1-INH(IV) 500 IU BIW (RR: 0.1107 [95% CI: 0.0234–0.5239]). Treatment with lanadelumab Q2W reduced the risk of total adverse events by 56.2% versus C1-INH(IV) 1000 IU BIW (RR:0.4377 [95% CI: 0.1536–1.2469]) and by 66.0% versus C1-INH(IV) 500 IU BIW (RR: 0.3401 [95% CI: 0.1234–0.9371]).
Conclusion:
This exploratory analysis suggested a trend toward greater efficacy and fewer adverse events with lanadelumab 150 mg Q2W compared with C1-INH(IV) BIW 1000 IU and 500 IU in pediatric patients with HAE. Future studies could potentially assess larger samples over longer periods of time for the long-term preventative efficacy, safety and tolerability of lanadelumab and C1-INH(IV).
Real-world ePRO use and clinical outcomes using electronic patient-reported symptom monitoring for patients with advanced non-small-cell lung cancer receiving first-line pembrolizumab
Authors: Blakely L. Johnetta , Oskar Sabine , Kudel Ian , Roush Ashley , Shamsi Zoya , Perry Toni , Christianson Annette , Smith Brittni , Burke Thomas 
Published: January 2025

Aim:
This ambispective observational study assessed the impact of Noona, an electronic patient-reported outcomes (ePRO) platform, for patients with non-small cell lung cancer (NSCLC) treated in a community oncology setting.
Methods:
Adults with advanced NSCLC, ECOG performance status of 0–2, who received first-line (1L) pembrolizumab (monotherapy or with chemotherapy) were eligible. Those initiating pembrolizumab from 1 July 2017 to 30 June 2019, identified retrospectively (historical cohort), were compared with those initiating pembrolizumab from 1 October 2019 to 30 September 2021 who were prospectively offered Noona (standard of care [SoC] cohort). The Kaplan–Meier method and Cox proportional hazards models were used to compare pembrolizumab real-world time on treatment (rwToT; primary outcome measure) and rw time to next treatment or death (rwTTNTD) between historical and SoC cohorts. Healthcare resource use (HCRU) was compared using generalized linear models with Poisson distribution. Analyses were repeated to compare outcomes in the SoC cohort between Noona users (created a profile and used any function ≥one-time during 1L therapy) and nonusers with >42 days on 1L pembrolizumab. Data cutoff was 30 June 2020 and 30 September 2022 for historical and SoC cohorts, respectively.
Results:
Median pembrolizumab rwToT was 4.4 months (95% CI: 3.9–5.1) in the historical cohort (n = 448) versus 4.1 months (95% CI: 3.3–4.8) in the SoC cohort (n = 462; adjusted hazard ratio [aHR], 0.9; 95% CI: 0.8–1.0; p = 0.14 vs historical cohort). In the SoC cohort, 147 of 341 eligible patients (43%) established a Noona profile; 122/341 (36%) were Noona users. Median rwToT was 6.4 months (95% CI: 5.1–7.4) and 6.9 months (95% CI: 5.6–7.6) among Noona users and Noona nonusers (n = 219), respectively (aHR, 1.1; 95% CI: 0.8–1.4; p = 0.95 vs Noona users). The rwTTNTD and HCRU were comparable in historical versus SoC cohorts and for Noona users versus nonusers. During the first year after establishing a Noona profile, 92 of 147 patients (63%) used the platform; monthly use was 32–42%, and checking laboratory results was the most used function overall (by 52% of the 147).
Conclusion:
Notwithstanding the null findings of this study, positive results of ePRO use in clinical trials and observational studies support the treatment-related symptom monitoring and survival benefits of ePRO utilization.
A real-world analysis of antidepressant medications in US veterans aged 60 years and older: a comparative analysis
Authors: Pittman Ryan D , Sutton S Scott , Magagnoli Joseph , Cummings Tammy H 
Published: January 2025

Aim:
To compare the safety and efficacy of antidepressants (AD) among older adults with major depressive disorder (MDD) by assessing treatment change, augmentation and hospitalization rates.
Methods:
This retrospective study analyzed data from the Veterans Affairs (VA) database, including 142,138 patients aged ≥60 years diagnosed with MDD. Patients prescribed bupropion, citalopram, duloxetine, escitalopram, fluoxetine, mirtazapine, paroxetine, sertraline, or venlafaxine were included. Outcomes were treatment change, augmentation and hospitalization rates. Hazard ratios (aHRs) were calculated using sertraline as the reference.
Results:
Of the patients, 39.6% required augmentation, 18.1% changed antidepressant treatment and 13.3% were hospitalized. The corresponding incidence rate was 544, 124 and 122 events per 1000 person-years. Compared with sertraline, mirtazapine users had the highest AD change risk (aHR 1.34, 95% CI: 1.29–1.40), while duloxetine users had the lowest (aHR 0.87, 95% CI: 0.83–0.92). Duloxetine also had the lowest augmentation risk (aHR 0.89, 95% CI: 0.86–0.92). Mirtazapine users also had the highest risks of augmentation (aHR 1.15, 95% CI: 1.12–1.18) and hospitalization (aHR 1.14, 95% CI: 1.07–1.23). Bupropion had the lowest hospitalization risk (aHR 0.77, 95% CI: 0.71–0.84).
Conclusion:
Antidepressant choice significantly influences treatment outcomes in older adults with MDD. Duloxetine demonstrated the best profile with the lowest risks of AD change and augmentation, while mirtazapine posed the highest risks of all three outcomes. Personalized treatment strategies are crucial to improving outcomes in this population.
Determination of The Level of Paracetamol and Tramadol Hcl Mixture in Tablets by Chemometric Method by Fourier Transform Infrared Spectrophotometry
Authors: Purba Gratia Apulina Cindylawsa , Muchlisyam Muchlisyam , Putra Effendy De Lux 
Published: January 2025

Fixed-dose combinations of paracetamol and tramadol HCl are effective in the treatment of moderate to severe pain. Therefore, the determination of the levels of the mixture of paracetamol and tramadol HCl is very important for the pharmaceutical industry. The purpose of this study was to determine the levels of paracetamol and tramadol HCl mixture using Fourier Transform Infrared combined with partial least square (PLS) chemometric method. This study was conducted by making a calibration model and chemometric validation of each of the five concentrations measured absorbance at specific wave numbers of paracetamol and tramadol HCl. The results of the study on PLS multivariate calibration of paracetamol and tramadol HCl with RMSECV values of 0.06279 and 0.03785, PRESS values of 0.02366 and 0.00860, and R2 values of 0.9995 0.9998, respectively. All validation parameters are within the acceptable range. This indicates that the method can be used to accurately determine drug levels without separation
Application of the Talking Stick Learning Model to Improve Early Childhood Physical Motor Skills
Authors: Hadidja Sitti , Herlina Herlina , Bachtiar Muhammad Yusri , Wahira Wahira 
Published: January 2025

The Talking Stick learning model is interpreted as a learning model for playing sticks, designed to measure the mastery of learning materials, foster learning motivation and create a fun learning atmosphere for students by using sticks. This research focuses on the Application of the Talking Stick Learning Model by Utilizing Used Goods to Improve Physicalmotor Skills in Early Childhood. The purpose of this study is to find out the Application of the Talking Stick Learning Model by Utilizing Used Goods to Improve Children's Physicalmotor Skills after early childhood The type of research used is a type of qualitative research with a case study approach. The results of the study are as follows: 1) The Talking Stick learning model is implemented in early childhood, where teachers provide direct guidance. The application of the talking stick learning model is carried out in the process of activities that can improve children's oral language skills in the future As for the inhibiting factors in Talking Stick learning that "one of the disadvantages of Talking Stick is that when students do not understand the lesson, then students will feel anxious and worried when Talking Stick in his hands. Meanwhile, the Supporting Factors are to test students' readiness in mastering the subject matter, practicing reading and understanding the subject matter quickly, according to the material that has been delivered and to be more active in learning because students never know that the stick will be their turn.
Application of Experimental Methods in Science Learning to Improve Early Childhood Thinking Skills
Authors: Sapia Sapia , Herlina Herlina , Bachtiar Muhammad Yusri , Wahira Wahira 
Published: January 2025

This study aims to: 1) provide a description of the application of experimental methods in science learning to improve early childhood thinking skills; 2) knowing the Supporting Factors and Inhibiting Factors in the Application of Experimental Methods in Science Learning to Improve Early Childhood Thinking Skills. The research subjects consisted of three information people, namely 2 teachers and 1 principal. The experimental method was chosen because it is considered to be able to provide direct experience that stimulates children's active involvement in learning, so that it can increase their understanding of science concepts in depth. This study uses a qualitative descriptive approach, collecting data through observation, interviews, and documentation. The results of the study show that the application of experimental methods in science learning is able to improve the ability to think critically, logically, and creatively in early childhood. The main supporting factors for the success of this method are the availability of adequate facilities and infrastructure, as well as the active involvement of teachers as facilitators. The obstacles faced include a lack of time in implementing the experiment and limited teachers' understanding of the use of this method.
The Effect of Problem-Based Learning Model on the Ability to Recognize Geometric Shapes in Children Aged 5-6 Years
Authors: Saining Munirah , Rusmayadi Rusmayadi , Musi Muhammad Akil , Halik Abdul 
Published: January 2025

This study aims to find out the overview of the problem-based learning (PBL) learning model on the ability to recognize geometric shapes of children aged 5-6 years and to determine the influence of the Problem Based Learning (PBL) model on the ability to recognize geometric shapes of children aged 5-6 years. The approach used is a quantitative approach with a type of Quasi Experimental research with a research design, namely a nonequaivalent control group design. The population in this study is children aged 5-6 years. The sampling in this study is cluster random sampling. The sample in this study is 14 children with 7 children as the experimental group and 7 children as the control group. The data analysis techniques used are descriptive statistical analysis and non-parametric statistical analysis. The results of data analysis obtained Asym (2-tailed) = 0.017 < 0.05 HI accepted and H0 rejected, meaning that the geometry ability of children who were treated with the problem-based learning model in the experimental group experienced significant development compared to the control group. This shows that the problem-based learning learning model significantly influences the geometry ability of children aged 5-6 years.
Hallazgos clínicos y endoscópicos en niños con hemorragia digestiva inferior
Authors: Ainslie Katherine , Gómez Eleana , Silva Carlos , Blanco Karolin , Colina Nina , Mosquera Nazareth 
Published: January 2025

Introducción: La hemorragia digestiva inferior es aquella que tiene su origen en el tubo digestivo distal al ángulo de Treitz. Es más frecuente en sexo masculino, su incidencia aumenta con la edad. Puede variar de un evento no preocupante a un episodio agudo que compromete la vida cuyas causas son múltiples, por lo que es necesaria una investigación minuciosa y la realización de estudios endoscópicos. Objetivo: Determinar hallazgos clínicos y endoscópicos en niños con hemorragia digestiva inferior que acuden a la Unidad de Gastroenterología y Nutrición Pediátrica del Hospital Militar Universitario “Dr. Carlos Árvelo” en una serie de casos. Métodos: Enfoque cuantitativo, de diseño observacional, prospectivo, no experimental, nivel descriptivo de corte transversal. La población de estudio estuvo constituida por 20 pacientes, a quienes se les realizó estudio colonoscópico. Resultados: La edad promedio fue de 6,5 años, predominó el sexo masculino (60%), estrato sociodemográfico: Graffar IV (50,00%), uso de antibioticoterapia previa (60,5%) y dieta baja en fibra (96,79%). Los síntomas y signos más encontrados fueron dolor abdominal (40,00%) y rectorragia (85,00%) respectivamente. El hallazgo endoscópico más frecuente fue pólipo rectal(85,00%), histológicamente reportando: pólipo de retención juvenil: (95,00%). Conclusión: La rectorragia y dolor abdominal representan las manifestaciones clínicas más comunes de hemorragia digestiva inferior en niños, cuya etiología predominante fue el pólipo rectal de retención juvenil.ESCUCHE EL RESUMEN HANCIENDO CLIC EN EL IDIOMA DE SU PREFERENCIA:EspañolEnglishPortugues
Elastografía esplénica en niños con cavernomatosis de la porta
Authors: Malavé Maritza , Colina Nina , Dagher Lucy , Ruiz Maygreg 
Published: January 2025

Introducción: La cavernomatosis portal, generalmente secundaria a la trombosis de la vena porta, provoca hipertensión portal que conlleva a sangramiento digestivo. Objetivo: Evaluar la utilidad de la elastografía esplénica en niños con diagnóstico de cavernomatosis de la porta. Pacientes y Métodos: Investigación de campo, cuasi experimental, prospectivo, longitudinal, muestra 10 pacientes. Resultados: El 100% estrato socioeconómico III. Ambos sexos frecuencia 50%, adolescentes (tempranos y tardíos) 50% cada grupo, promedio 14,8 años (rango 14-17 años DE +/- 1,03 años). 100% peso superior a 36 kg, promedio 45,51 Kg (rango 35-58 kg, DE +/- 9,17 kg), 80% talla mayor a 1,45 m, promedio 1,55 m (rango1,35-1,8 m DE +/- 0,13 m), IMC 50% los rangos bajo y normal, el 100% perímetro torácico mayor de 75 cm. 100% con várices esofágicas grandes, 100% niveles mayores 45 KPa en elastografía esplénica, 80% trombocitopenia moderada, 100% F0 de fibrosis hepática, el 90% esteatosis hepática S0. 100% flujo portal bajo y esplenomegalia, 40% entre 80 y 100 KPa en elastografía hepática. Conclusiones: La elastografía esplénica en pediatría es útil reportando IQR/MED promedio 2,52 KPa, el resultado > 45 KPa es un parámetro no invasivo funciona como predictor de riesgo de presentar varices esofágicas.ESCUCHE EL RESUMEN HANCIENDO CLIC EN EL IDIOMA DE SU PREFERENCIA:EspañolEnglishPortugues
Hubungan Antara Motivasi dan Disiplin Kerja Dengan Produktivitas Kerja Perawat di Ruang Rawat Inap RS Melati Tangerang
Authors: Deswita Reny 
Published: January 2025

Latar Belakang: Produktivitas kerja perawat merupakan faktor yang penting dalam meningkatkan dan mengembangkan mutu pelayanan rumah sakit. Produktivitas dalam keperawatan bersifat kompleks dan berdampak pada perawatan pasien. Apabila produktivitas perawat rendah maka kinerja perawat dalam melakukan pelayanan keperawatan akan menurun. Akibatnya kepuasan klien sebagai penerima jasa pelayanan keperawatan tidak terpenuhi dengan baik, sehingga mutu pelayanan keperawatan menurun. Selain itu, produktivitas perawat yang tidak baik cenderung menghasilkan kualitas dokumentasi yang tidak baik juga. Tujuan: Tujuan penelitian ini adalah untuk menganalisis hubungan antara motivasi dan disiplin kerja dengan produktivitas kerja. Metode: Penelitian kuantitatif dengan pendekatan Cross Sectional, sampel dalam penelitian ini adalah 65 responden. Penelitian ini dilakukan di RS Melati Tangerang sejak bulan April-Mei 2023. Penelitian ini menggunakan uji univariat untuk mengidentifikasi karakteristik responden dan uji Bivariat mengggunakan Uji Chi-Square digunakan untuk mengetahui hubungan antar variabel. Hasil: terdapat hubungan yang signifikan antara motivasi dan disiplin kerja dengan produktivitas kerja perawat dengan nilai p-value 0,000. 81,5 % responden memiliki motivasi kerja yang tinggi, 84,6 % responden memiliki disiplin kerja yang tinggi dan sebanyak 81,5 % responden memiliki tingkat produktivitas kerja yang tinggi. Kesimpulan: Motivasi dan disiplin kerja yang tinggi dapat meningkatkan produktivitas kerja sehingga meningkatkan mutu pelayanan keperawatan dan mencegah terjadinya kesalahan dalam melakukan asuhan keperawatan
YASMIQ TARKIBIDAGI SUVDA ERIYDIGAN VITAMINLAR MIQDORINI ANIQLASH
Authors: Isayev Y.T. , Mirzabayeva D.S. 
Published: January 2025

Mazkur maqolada yasmiq tarkibidagi vitaminlarning sog‘lom oziqlanishdagi ahamiyati va inson salomatligiga ta’siri tahlil qilinadi. Xususan, B guruhi vitaminlari, antioksidant xususiyatga ega C va E vitaminlari hamda foliy kislotasining organizm uchun ahamiyati yoritib berilgan. Yasmiq donlari tarkibidagi suvda eriydigan vitaminlar miqdori YuSSX metodi yordamida aniqlangan. Bunda o`rganilgan o`simlik materialida eng ko`p miqdorda folat kislotasi, ya`ni vitamin B9 mavjudligi qayd etilgan.
В данной статье представлены обсуждены результаты количественного определения водорастворимых витаминов зерен чечевицы. В частности, в вводной части описывается значение витаминов группы B, а также обладающих антиоксидантной активностью витаминов С и Е, фолиевой кислоты. Количественное определение витаминов проведен методом ВЭЖХ. Так, установлено, что в наибольшим количестве в растительном материале содержится фолиевая кислота или витамин B9.
This article presents the results of quantitative determination of water-soluble vitamins of lentil grains. In particular, the introductory part describes the importance of B vitamins, as well as vitamins C and E with antioxidant activity, folic acid. The quantitative determination of vitamins was carried out by HPLC. Thus, it was found that the greatest amount of folic acid or vitamin B9 is contained in plant material.
Pengadopsian Konvergensi IFRS Ditinjau dari Goodwill dan Aset Lainnya dalam Kombinasi Bisnis pada Laporan Keuangan PT Manufaktur Bidang Farmasi dan Kimia
Authors: Astri Ayu Pramesti  , Desinta Leba  , Angelina Wijaya Tan  , Yohana Natalia Cristanti  , Nadia Fransiska Dewi  , Ardhi Islamudin  
Published: January 2025

Transaksi kombinasi bisnis adalah salah satu indikator yang tertuang dalam konvergensi IFRS. Akses jaringan merupakan alasan PT Manufaktur Farmasi dan Kimia melakukan kombinasi bisnis. Tujuan penelitian ini adalah untuk memeriksa pengadopsian konvergensi IFRS dalam laporan keuangan PT Manufaktur Farmasi dan Kimia dengan melihat kebaikan dan aset lainnya dalam kombinasi bisnis. Penelitian ini diimplementasikan dengan pendekatan deskriptif kuantitatif. Data sekunder diterapkan pada penelitia ditemukan dari media perantara seperı. laporan keuangan sudah diaudit serta laporan tahunan perusahaan yang dipublikasikan di BEI pada periode 2015 hingga 2019. Metode pengumpulan data adalah penelitian pustaka dan penelitian laporan keuangan. Penelitian ini mengindikasikan bahwa Goodwill berpengaruh positif atas Nilai Perusahaan. Sementara Growth Opportunity serta Kombinasi Bisnis tidak berpengaruh atas Nilai Perusahaan. Good Corporate Governance tidak meningkatkan pengaruh Goodwill, Growth Opportunity atas Nilai Perusahaan. Sedangkan Good Corporate Governance meningkatkan pengaruh Business Combination atas Nilai Perusahaan.
Enhancing Productivity of Bread Wheat (Triticcum aestivum L.) Through Integrating Vermicompost and N fertilizer in Meskan District, Central Ethiopia
Authors: Teshome Yitbarek  , Rehima Redi  , Solomon Kibebew  
Published: January 2025

Soil fertility management is very crucial to optimize and sustain agricultural production so as to secure food for the current generation as well as the generation to come. Ethiopia is one of the food insecure countries in Sub-Saharan Africa. The country is striving to secure food through optimizing and sustaining crop production. The purpose of the study was to examine the combined effect of organic (vermicompost) and inorganic (nitrogen) fertilizer rates on growth and yield of bread wheat in Meskan distric, Central Ethiopia. The experiment used four levels of vermicompost (0, 1, 1.5, and 2 t ha-1) and Nitrogen (0, 50 percent recommended rate of N (RN), 75 percent RN, and 100 percent RN) in a factorial combination in RCBD design with three replications using a wheat variety (Kekeba) as the test crop. The result of the study asserted that yield and yield-related traits were significantly different at P < 0.05. The treatment of 2 t ha-1 vermicompost + 75 percent of RN produced the maximum grain yield (2773 kg ha-1); while the control produced the lowest grain yield (1062 kg ha-1). Combined application of organic fertilizer (vermicompost) and inorganic fertilizer (N) optimizes wheat production in the study area. Sole application of organic fertilizer (vermicompost) and inorganic fertilizer (N) would not bring optimum production of wheat. Therefore, combined application of organic and inorganic fertilizers could have great contribution towards food security for countries like Ethiopia with low fertilizers input user and high food insecurity level.