bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy and safety of granulocyte colony-stimulating factor in the treatment of acute-on-chronic liver failure: A systematic review and meta-analysis
Authors: Qiu Bo , Liang Jia Xu , Romero Gómez Manuel 
Published: November 2023

Background and objectives
The safety and efficacy of granulocyte-colony stimulating factor (G-CSF) for the treatment of acute-on-chronic liver failure (ACLF) remain controversial. This meta-analysis aimed to evaluate the effectiveness and safety of G-CSF in treating ACLF.

Methods
The estimated pooled risk ratio (RR) and 95% confidence interval (CI) assessed the treatment effects of G-CSF. Mean differences (MD) and 95% confidence intervals were used to analyze continuous data. Heterogeneity was explored by sensitivity analysis. Potential publication bias was assessed using Egger’s test.

Results
Ten studies, comprising a total of 603 participants, were included in the analysis. The G-CSF group showed significantly lower MELD scores at 7-day (MD = -2.39, 95%CI: -3.95 to -0.82), CTP scores at 7-day (MD = -0.77, 95%CI: -1.41 to -0.14), and MELD scores at 30-day (MD = -3.01, 95%CI: -5.36 to -0.67) compared to the control group. Furthermore, the G-CSF group was associated with a reduced risk of sepsis (RR = 0.53, 95%CI: 0.35–0.80). The 30-day survival (RR = 1.26, 95%CI:1.10–1.43), 60-day survival (RR = 1.47, 95%CI:1.17–1.84, and 90-day survival (RR = 1.73, 95%CI: 1.27–2.35) of patients with ACLF treated with G-CSF were significantly higher than those of the control group.

Conclusions
Our meta-analysis suggests that G-CSF therapy may be a promising treatment for ACLF, with significant improvements in liver function and survival rates, however, further studies are needed to verify this conclusion.
Definitions of successful aging among middle-aged Latinas residing in a rural agricultural community
Authors: Ambriz Elizabeth , De Pierola Camila , Calderon Norma M. , Calderon Lucia , Kogut Katherine , Deardorff Julianna , Torres Jacqueline M. 
Published: November 2023

Introduction
Latinos are the fastest growing aging population in the U.S. However, there has been limited attention to conceptualizing successful aging among Latinos, especially those residing in rural communities. Latinos are the largest racial or ethnic group residing in rural underserved communities and rural Latinos experience significant structural barriers to access the conditions they need to age well. The goal of this study is to make unique contributions to the successful aging literature by describing what successful aging means for middle-aged Latinas residing in a rural community.

Methods
This qualitative paper used inductive thematic content analysis to examine definitions of successful aging among Latina women (n = 40) residing in an underserved agricultural community and entering mid-life (mean = 49 years old; age range 40–64).

Results
With regards to definitions of successful aging, four themes emerged: 1) Having good health; 2) maintaining an active lifestyle; 3) the wellbeing of one’s children; and 4) being independent.

Discussion
Participants’ definitions of successful aging aligned to some extent with existing frameworks, specifically related to health and independence. However, middle-aged Latina participants’ unique definitions of successful aging also diverged from existing frameworks, especially around the wellbeing of their children and the importance of work as a way of maintaining an active lifestyle. More research is needed to understand the unique social context and circumstances of middle-aged Latinos residing in rural communities and how they influence their aging journeys. This can provide important information for the development of culturally sensitive services, interventions, and policies to help Latinos age well.
Kinematic alteration in three-dimensional reaching movement in C3-4 level cervical myelopathy
Authors: Noguchi Naoto , Akiyama Ryoto , Kondo Ken , Vo Duy Quoc , Sato Lisa , Yanai Akihito , Ino Masatake , Lee Bumsuk 
Published: November 2023

Object
This study aimed to compare the reaching movement between two different spinal cord compression level groups in cervical myelopathy (CM) patients.

Methods
Nine CM patients with maximal cord compression at the C3-4 level (C3-4 group) and 15 CM patients with maximal cord compression at the C4-7 level (C4-7 group) participated in the study. We monitored three-dimensional (3D) reaching movement using an electronic-mechanical whack-a-mole-type task pre-and post-operatively. Movement time (MT) and 3D movement distance (MD) during the task were recorded. An analysis of variance for split-plot factorial design was performed to investigate the effects of compression level or surgery on MT and MD. Moreover, we investigated the relationship between these kinematic reaching parameters and conventional clinical tests.

Results
The 3D reaching trajectories of the C3-4 group was unstable with higher variability. The C3-4 group showed longer MT (p < 0.05) and MD (p < 0.01) compared with the C4-7 group both before and after surgery. Moreover, MT was negatively correlated with the Japanese Orthopedic Association score only in the C3-4 group (r = - 0.48).

Conclusion
We found that spinal cord compression at the C3-4 level had a negative effect on 3D reaching movement and the kinematic alteration influenced the upper extremity performance. This new knowledge may increase our understanding of kinematic alteration in patients with CM.
Home delivery among women who had optimal ANC follow-up in Sub-Saharan Africa: A multilevel analysis
Authors: Zegeye Alebachew Ferede , Negash Wubshet Debebe , Kassie Alemneh Tadesse , Wassie Likinaw Abebaw , Tamir Tadesse Tarik 
Published: November 2023

Background
Home deliveries, where most births take place, are significantly responsible for the majority of maternal mortality. In order to develop appropriate policies and methods that could aid in addressing the issue, it is important to understand the scope of home delivery and its determinants in developing countries. Therefore, this study aims to ascertain the prevalence and factors associated with home delivery among women who had optimal ANC follow up in the Sub-Saharan Africa countries.

Methods
A population based cross-sectional study was conducted. Data from the most recent Demographic and Health Surveys, which covered 23 Sub-Saharan Africa countries from 2014 to 2020, were used. The study used a total of 180,551 women who had optimal ANC follow up weighted sample. Stata 14 was used to analyze the data. The determinants of home delivery were determined using a multilevel mixed-effects logistic regression model. Factors associated with home delivery in the multilevel logistic regression model were declared significant at p-values <0.05. The adjusted odds ratio and confidence interval were used to interpret the results.

Results
In Sub-Saharan Africa, three in ten (30%) women who had optimal ANC follow-up gave birth at home. Individual-level variables such as maternal age (20 to 35 years) (AOR = 1.27, 95% CI: 1.10, 1.46), no formal education (AOR = 3.10, 95% CI: 2.68, 3.59), pregnancy complications (AOR = 0.74, 95% CI: 0.67, 0.82), distance to a health facility (AOR = 1.43, 95% CI: 1.30, 1.58), and poor wealth status (AOR = 2.71, 95% CI: 2.37, 3.10) had higher odds of home delivery. Community-level variables such as rural residence (AOR = 2.83, 95% CI: 2.48, 3.22), living in central Sub-Saharan Africa (AOR = 7.95, 95% CI: 5.81, 10.9), and eastern Sub-Saharan Africa (AOR = 2.74, 95% CI: 2.09, 3.59), were significantly associated with home delivery.

Conclusions and recommendation
This study concludes that home delivery in sub-Saharan Africa among women who had optimal ANC follow-up were high. The study identified that both individual and community-level variables were determinants of home delivery. Therefore, the Government and ministries of health in Sub-Saharan Africa countries should give attention to those women who reported distance as a big problem to health facilities and for rural resident women while designing policies and strategies targeting reducing home delivery in sub-Saharan Africa.
PREPARATION OF NEW GLYCYRRETIC ACID DERIVATIVES WITH NITROGEN-CONTAINING LIGANDS
Authors: Esanov Rakhmat Sulton ugli , Ishimov Uchkun Zhomuradovich , Gafurov Makhmudzhon Bakiyevich , Sobirova Fotima Azamjonovna , Matchanov Alimzhan Davlatbaevich 
Published: November 2023

This article presents the results of a study of obtaining new derivatives of glycyrrhizic acid aglycone with nitrogen-containing ligands. Natural compounds isolated from plant materials are relatively low toxic, can exhibit unique physical and chemical properties, and have a wide range of biological activity. One of these natural compounds is 3β-hydroxy-11-oxo-12-en-18βН, 20β-olean-30 acid, 3-О-(2҆-О-β-D-glucuronopyranosyl)-β-D-glucuronopyranoside (glycyrrhizic acid, GK) is the main active principle of licorice root (Glycyrrhiza glabra L.), which grows on the territory of the Republic of Uzbekistan and is a renewable natural source. With the ability to self-organize and recognize other particles and molecules, natural biologically active compounds are the subject of current chemical research aimed at modeling various biochemical processes. One of such widespread natural compounds are plant triterpenoids, glycyrrhizic (GA), glycyrrhetic (GlK), oleanolic, betulinic and ursalic acids, etc.
The article also presents the results of a study of the dependence of the complex formation of GlK with nitrogen-containing ligands depending on the structural changes in the guest molecule. New supramolecular derivatives of GlK with some nitrogen-containing ligands were obtained by the liquid phase method, their physicochemical and spectral (UV, IR) characteristics of the synthesized compounds were determined, and the chemical structure was analyzed on the basis of mass spectrometry data.
Developmental fluoxetine exposure affects adolescent and adult bone depending on the dose and period of exposure in mice
Authors: Fricke Hannah P. , Krajco Chandler J. , Perry Molly J. , Desorcy‐Scherer Katelyn M. , Wake Lella A. , Charles Julia F. , Hernandez Laura L. 
Published: November 2023

AbstractAt the end of gestation, fetal skeleton rapidly accumulates calcium, and bone development continues in offspring postnatally. To accommodate, maternal skeletal physiology is modulated in a serotonin‐dependent manner. Selective serotonin reuptake inhibitors (SSRIs) are generally considered safe for treatment of major depressive disorder, postpartum depression, and other psychiatric illnesses during the peripartum period, but because serotonin affects bone remodeling, SSRIs are associated with decreased bone mass across all ages and sexes, and the impact of SSRIs during fetal and postnatal development has not been fully investigated. In the present study, our aim was to examine developmental fluoxetine exposure on offspring skeleton and to assess varying degrees of impact depending on dose and window of exposure in short‐term and long‐term contexts. We established that a low dose of lactational fluoxetine exposure caused a greater degree of insult to offspring bone than either a low dose during fetal and postpartum development or a high dose during lactation only in mice. We further discovered lasting impacts of developmental fluoxetine exposure, especially during lactation only, on adult bone and body composition. Herein, we provide evidence fluoxetine exposure during early development may have detrimental effects on the skeleton of offspring at weaning and into adulthood.
Down-regulation of COL1A1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer
Authors: Ma Bin , Li Fangfang , Ma Binlin 
Published: November 2023

Abstract
We investigated the effects of collagen type I alpha 1 (COL1A1) on tumor-associated fibroblast activation and matrix remodeling in the tumor microenvironment of breast cancer. Cells were divided into the blank control, negative control, and siRNA-COL1A1 groups, or HKF control, HKF + exosomes (EXO), HKF + siRNA negative control-EXO, and HKF + siRNA-COL1A1-EXO co-culture groups. Western blot and quantitative real-time PCR detected gene expressions. COL Ⅰ, COL Ⅲ, and TGF-β1 were detected by enzyme-linked immunosorbent assay. We found that compared with blank and negative control groups, COL1A1 expression and the secretion of exosomes by breast cancer cells were inhibited in the siRNA-COL1A1 group. Compared with the HKF control group, the COL Ⅰ, COL Ⅲ, TGF-β1, α-SMA, and fibroblast activation protein (FAP) were increased, while the E-cadherin and CAV-1 were decreased in the HKF + EXO, HKF + siRNA negative control-EXO, and HKF + siRNA-COL1A1-EXO co-culture groups. Compared with HKF + EXO and HKF + siRNA negative control-EXO co-culture groups, the COL Ⅰ, COL Ⅲ, TGF-β1, α-SMA, and FAP were decreased, and the E-cadherin and CAV-1 were increased in the HKF + siRNA-COL1A1-EXO co-culture group. Collectively, COL1A1 down-regulation may inhibit exosome secretion possibly via inhibiting COL Ⅰ and upregulating CAV-1, thereby inhibiting tumor-associated fibroblast activation and matrix remodeling in the tumor microenvironment.
Interfuel Substitution and Inflation Dynamics in India
Authors: Sengupta Anirban , Serletis Apostolos , Xu Libo 
Published: November 2023

Abstract
This paper uses neoclassical microeconomic theory to investigate the demand for energy and interfuel substitution in India at the sectoral level. It makes full use of the relevant economic theory and econometrics and generates inference in terms of Allen and Morishima elasticities of substitution that are internally consistent with the data and nonlinear models used. The results indicate that the interfuel substitution elasticities are consistently below unity in the household and power sectors, revealing the limited ability to substitute between major energy commodities in these two sectors. However, significant substitution relationships are found in the industrial and transportation sectors, suggesting that energy price changes in these sectors will significantly shift the demand for energy and consumption. Based on measured elasticities of substitution, we also discuss implications of energy price shocks on inflation and inflation targeting strategies by the central bank.
Volatility Forecasting Using Quasi-Score-Driven Models with an Application to the Coronavirus Pandemic Period
Authors: Ayala Astrid , Blazsek Szabolcs , Licht Adrian 
Published: November 2023

Abstract
We study the statistical and volatility forecasting performances of the recent quasi-score-driven EGARCH (exponential generalized autoregressive conditional heteroscedasticity) models. We compare the quasi-score-driven EGARCH models with GARCH, asymmetric power ARCH (A-PARCH), and all relevant score-driven EGARCH models of the literature. For score-driven and quasi-score-driven EGARCH, we use the following seven score-driven probability distributions: Student’s t-distribution; general error distribution (GED); generalized t-distribution (Gen-t); skewed generalized t-distribution (Skew-Gen-t); exponential generalized beta distribution of the second kind (EGB2); normal-inverse Gaussian distribution (NIG); Meixner distribution (MXN). We use all combinations of those distributions for (i) the probability distribution of the dependent variable, and (ii) the probability distribution which defines the quasi-score function updating term of the quasi-score-driven filters. We use daily data for the Standard & Poor’s 500 (S&P 500) index. We find that both in-sample and out-of-sample, quasi-score-driven EGARCH is superior to GARCH, A-PARCH, and score-driven EGARCH. We report in-sample results for the period of January 2000 to December 2020, providing evidence in favor of the quasi-score-driven EGARCH model for the last two decades. We report out-of-sample volatility forecasting results for a period within the coronavirus disease 2019 (COVID-19) pandemic, providing evidence in favor of the quasi-score-driven EGARCH model for a crisis period.
La participation parentale à l’établissement des plans d’intervention d’élèves en difficulté d’adaptation
Authors: Chouinard Jeanne , Gaudreau Nancy , Massé Line 
Published: November 2023

Le plan d’intervention (PI) constitue un outil de planification mis en place pour favoriser la réussite des élèves présentant des difficultés d’adaptation. Dans cette optique, la participation des parents est attendue de la part de l’école. Quelle forme celle-ci prend-elle ? Quels facteurs facilitent ou entravent la participation parentale ? Cet article présente les résultats d’une recherche qualitative menée au Québec auprès de 29 parents d’élèves présentant des difficultés d’adaptation. Les analyses réalisées permettent de dégager certaines recommandations pour favoriser une plus grande participation des parents à la démarche du PI de leur enfant.
Integrated systems biology approach identifies gene targets for endothelial dysfunction
Authors: Pinheiro‐de‐Sousa Iguaracy , Fonseca‐Alaniz Miriam Helena , Giudice Girolamo , Valadão Iuri Cordeiro , Modestia Silvestre Massimo , Mattioli Sarah Viana , Junior Ricardo Rosa , Zalmas Lykourgos‐Panagiotis , Fang Yun , Petsalaki Evangelia , Krieger José Eduardo 
Published: November 2023

AbstractEndothelial dysfunction (ED) is critical in the development and progression of cardiovascular (CV) disorders, yet effective therapeutic targets for ED remain elusive due to limited understanding of its underlying molecular mechanisms. To address this gap, we employed a systems biology approach to identify potential targets for ED. Our study combined multi omics data integration, with siRNA screening, high content imaging and network analysis to prioritise key ED genes and identify a pro‐ and anti‐ED network. We found 26 genes that, upon silencing, exacerbated the ED phenotypes tested, and network propagation identified a pro‐ED network enriched in functions associated with inflammatory responses. Conversely, 31 genes ameliorated ED phenotypes, pointing to potential ED targets, and the respective anti‐ED network was enriched in hypoxia, angiogenesis and cancer‐related processes. An independent screen with 17 drugs found general agreement with the trends from our siRNA screen and further highlighted DUSP1, IL6 and CCL2 as potential candidates for targeting ED. Overall, our results demonstrate the potential of integrated system biology approaches in discovering disease‐specific candidate drug targets for endothelial dysfunction.
Profitabilitas dalam Memediasi Pengaruh Kepemilikan Institusional, Komite Audit, dan Ukuran Perusahaan terhadap Pengungkapan Sustainability Report
Authors: Roviqoh Devi Istiani , Khafid Muhammad 
Published: November 2023

Tujuan penelitian dilakukan adalah menguji pengaruh kepemilikan institusional, komite audit, dan ukuran perusahaan terhadap pengungkapan sustainability report dengan variabel intervening profitabilitas. Populasi dalam penelitian ini adalah perusahaan yang termasuk kategori indeks LQ45 periode 2013-2017 sebanyak 70 perusahaan. Teknik sampel yang digunakan pada penelitian ini yaitu purposive sampling. Sampel yang diperoleh sebanyak 14 perusahaan sehingga diperoleh total 70 unit analisis. Teknik analisis yang digunakan adalah analisis statistik deskriptif dan path analysis dengan software IBM SPSS Statistics 23. Penelitian ini menunjukkan adanya pengaruh positif profitabilitas terhadap pengungkapan sustainability report, komite audit berpengaruh positif terhadap profitabilitas, dan ukuran perusahaan berpengaruh negatif terhadap profitabilitas. Sedangkan kepemilikan institusional, ukuran perusahaan, dan komite audit tidak mempengaruhi pengungkapan sustainability report, serta kepemilikan institusional tidak berpengaruh terhadap profitabilitas. Hasil Sobel Test menunjukkan profitabilitas mampu memediasi pengaruh ukuran perusahaan dan komite audit terhadap pengungkapan sustainability report, namun tidak mampu memediasi pengaruh kepemilikan institusional terhadap pengungkapan sustainability report. Simpulan penelitian yaitu pengungkapan sustainability report akan lebih tinggi ketika ukuran perusahaan dan komite audit yang dimiliki, ditunjang dengan tingginya tingkat profitabilitas perusahaan. Hal tersebut menunjukkan bahwa manajemen hendaknya menjaga profitabilitas perusahaan karena terbukti berpengaruh langsung dan mampu memediasi terhadapÂ pengungkapan sustainability report.
The Impact of Consumer Price Index, Foreign Direct Investment, Bank Credit and Labour Force on Economic Growth in Indonesia
Authors: Lamah Abdulhadi Ieweedat Ali , Yanto Heri , Setyadharma Andryan 
Published: November 2023

This study aims to analyse the impact of consumer price index on GDP, to analyse the im-pact of Foreign Direct Investment (FDI) on GDP, to analyse the impact of bank credit on GDP, to analyse the impact of Labour Force on GDP. The sample in this study are the data for GDP, direct investment (FDI), bank credit, Consumer Price Index, and the labour force with annual data for fourteen consecutive years that are from period 2005-2019 years. ECM with e-views programs used to analyse the data. Based on the results of data analysis and discussion that has been presented, the following conclusions can be drawn that Con-sumer Price Index (CPI) has no impact on GDP in short term and long term, Foreign Direct Investment (FDI) has an impact on GDP in short term and long term, Bank Credit (BC) has no impact on GDP in short term and long term, Labour Force (LB) has no impact on GDP in short term and long term.
Evaluasi Program Theurapetic Feeding Center dalam Upaya Penanganan Kasus Gizi Buruk pada Balita di Kabupaten Tegal (Studi Kasus di Wilayah Kerja Puskesmas Bumijawa, Tegal Tahun 2021)
Authors: Umami Nur Atik , Farida Eko 
Published: November 2023

ABSTRAK
Latar belakang : Kasus gizi buruk di Jawa Tengah mengalami peningkatan sejak empat tahun terakhir. Pada tahun 2019 prevalensi gizi buruk di Kabupaten Tegal menempati urutan kedua tertinggi yaitu 10,4%. Puskesmas Bumijawa merupakan salah satu puskesmas dengan kasus gizi buruk tertinggi dan merupakan satu-satunya Puskesmas di Kabupaten Tegal yang telah berhasil mendirikan Program Theurapetic Feeding Centre (TFC) sebagai upaya dalam mengatasi gizi buruk pada balita. Untuk itu, perlu dilakukan penelitian dalam mengevaluasi program yang ditinjau dari komponen input, proses dan output. Metode : Jenis penelitian kualitatif yang dilengkapi dengan data-data kuantitatif dengan desain penelitian analisis deskriptif. Informan dipilih secara purposive sampling dan snowball sampling dengan kriteria tertentu yang terdiri dari 4 informan utama dan 4 informan triangulasi. Teknik pengambilan data dilakukan dengan wawancara mendalam, observasi dan telaah rekam medis. Data kualitatif dianalisis menggunakan model analisis Miles dan Huberman sedangkan kuantitatif dengan deskriptif presentase. Hasil : Hasil menunjukkan bahwa program TFC dapat dikatakan cukup baik . Hal ini terlihat dari komponen input (petugas, dana, bahan dan waktu pelaksanaan sudah baik, namun masih terdapat kendala dalam peralatan yang masih kurang memadai dan masih ada paket makanan yang tidak sesuai dengan sasaran program). Komponen proses (tahap penemuan kasus sudah sesuai dengan panduan, penanganan kasus sesuai dengan kondisi balita, serta pemulihan yang sudah dilakukan orang tua balita di rumah. Namun dalam tahapan pemulihan orang tua balita merasa kesulitan tersendiri dalam menyokong pemulihannya selama di rumah). Kemudian pada komponen output (dalam waktu 3 bulan balita gizi buruk mengalami kenaikan berat badan selama mengikuti program TFC). Kesimpulan : Program TFC Puskesmas Bumijawa sudah berjalan cukup baik dalam mengatasi masalah gizi buruk pada balita, namun masih ada beberapa kendala dalam pelaksanaan yang harus di perbaiki agar pelaksanaan program berjalan maksimal.