bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Modified Mediterranean and Dietary Approaches to Stop Hypertension (DASH) Dietary Patterns Interact with Psychological Disorders on Sleep Quality and Quantity? YaHS-TAMYZ study
Authors: Sherafatmanesh Saeed , Madadizadeh Farzan , Hosseinzadeh Mahdieh , Mohammadi Mohammad , Mirzaei Masoud , Khosravi-Boroujeni Hossein , Salehi-Abargouei Amin 
Published: October 2023

Abstract

BackgroundThe separate relationship between dietary food intake and psychiatric illnesses on individuals' sleep has been discovered in previous investigations. However, it is yet unknown how these variables combine to affect the quantity and quality of sleep.ObjectiveThe purpose of the present cross-sectional study was to assess the possible interaction between Dietary Approaches to Stop Hypertension (DASH) and Modified Mediterranean (mMED) dietary patterns (DPs) and psychological ailments (PAs) on sleep quality and duration among Iranian adults, Yazd, Iran.Methods and Materials:Baseline data from a large Iranian cohort study (Yazd Health Study: YaHS-TAMYZ) were used in the current investigation. A validated food frequency questionnaire was utilized to obtain participants' dietary consumption. The adherence level of a priori DPs was calculated according to the earlier scientific literature. The depression, anxiety, and stress scale-21 (DASS-21) questionnaire was employed to assess PAs. To gather information regarding the individuals' sleep quality and duration, a nocturnal sleep questionnaire and short version of the Pittsburgh questionnaire were utilized. Finally, the multivariable adjusted binary logistic regression test was used to examine the interaction between DPs and PAs on sleep quality and duration.ResultsParticipants with the greatest adherence to the mMED DP and with severe depression had significantly lower odds of "low sleep quality" than those without depression signs and the lowest imitation of the diet (P for interaction: 0.039).ConclusionA Mediterranean-like diet might help those with severe depression among people with severe depression. Prospective investigations are needed to confirm this finding.Keywords: Mediterranean; Dietary Approaches To Stop Hypertension; Diet; Depression; Anxiety; Stress; Psychological Well-Being; Sleep
Quantitative trait loci detection for three tiller-related traits and the effects on wheat (Triticum aestivum L.) yields
Authors: Cai Yibiao , Zhou Xiaohan , Wang Chenyang , Liu Aifeng , Sun Zhencang , Li Shihui , Shi Xinyao , Yang Shuang , Guan Yuxiang , Cheng Jiajia , Wu Yongzhen , Qin Ran , Sun Han , Zhao Chunhua , Li Junming , Cui Fa 
Published: October 2023

Abstract

Tiller-related traits play an important role in determining the yield potential of wheat. Therefore, it is important to elucidate the genetic basis for tiller number when attempting to use genetic improvement as a tool for enhancing wheat yields. In this study, a quantitative trait locus (QTL) analysis of three tiller-related traits was performed on the recombinant inbred lines (RILs) of a mapping population, referred to as KJ-RILs, that was derived from a cross between the Kenong 9204 (KN9204) and Jing 411 (J411) lines. A total of 38 putative additive QTLs for spike number per plant (SNPP), maximum tiller number (MTN), and ear-bearing tiller rate (EBTR) were detected in eight different environments. Among the QTLs, three major and stable QTLs were first documented herein. The genetic effects of two co-located major and stable QTLs, i.e., qSnpp-KJ-5D.1 and qMtn-KJ-5D, for yield-related traits were characterized. These beneficial alleles were selected for wheat breeding programs, and their potential for future application in molecular breeding technology for yield improvement was evaluated. The candidate genes underlying qMtn-KJ-5D were predicted based on multi-omics data, and TraesKN5D01HG00080 was identified as a likely candidate gene. Overall, our results will help elucidate the genetic architecture of tiller-related traits and can be used to develop novel wheat varieties with high yields.
Delphi method applicability in drug foresight
Authors: Lintonen Tomi , Karjalainen Karoliina , Rönkä Sanna , Kotovirta Elina , Niemelä Solja 
Published: October 2023

Abstract

Background
The aim of the current study was to assess the accuracy of expert predictions, which were derived using a Delphi panel foresight study in 2010, on a variety of drug-related topics in Finland in 2020.
Methods
The material used to evaluate the accuracy of the predictions consists of published reports on statistics, survey results, official register data, wastewater analyses and official documents. Whenever possible, we used multiple information sources to ascertain possible changes related to the predictions.
Results
In 2010, the majority – but not all – of the experts accurately predicted an increase in drug use. Indeed, more people experimented with or used drugs, and more drug residues were found in wastewater monitoring. The experts also correctly predicted an increase in population-level approval of drug use, but this development has been rather slow. Contrary to predictions, there was no marked increase in the use of new synthetic drugs. However, the misuse of buprenorphine increased during the 2010s. In the drug market, unit prices were surprisingly stable over the ten-year period. There were no changes in legislation related to the legal status of drugs, as was foreseen by the experts. However, enforcement moved in the direction foreseen by the experts: more lenient measures have been taken against users. Drug care system reforms favored a combination of mental health and addiction care units between 2010 and 2020, as foreseen by the experts.
Conclusions
It seems to have been easier for the experts to foresee the continuation of existing trends, e.g., increasing use of drugs or widening approval of drugs, than to predict possible changes in the popularity of distinct groups of drugs such as new psychoactive substances (NPS). Even armed with the prediction that drug imports and wholesale would increasingly fall into the domain of organized crime, this undesirable development could not be stopped. Expert disagreement can also be seen as a valuable indication of uncertainty regarding the future. Foresight related to drug-related issues can produce relatively accurate and realistic views of the future at least up to ten years ahead.
Prediction of the success rates after endoscopic treatment of stone related ureteral stricture: Could the assesement of ureteral wall thickness play a role?
Authors: Sahin Cahit , Sobay Resul , Sinanoglu Orhun , Arikan Ozgur , Uslu Mehmet , Bicaklioglu Fatih , Sahinler Emre Burak , Yildirim Salih , Sarica Kemal 
Published: October 2023

Abstract

To evaluate the role of certain radiological parameters in predicting the success of endoscopic treatment in ureteral strictures formation.
51 adult patients with ureteral stricture formation (< 1cm) after ureteroscopic removal of proximal ureteric stones were included and in addition to stone and patient parameters, radiological parameters including ureteral wall thickness (UWT) at the impacted stone site were also measured on computed tomography (CT) images. Patients were evaluated in two groups: Group 1: Patients in whom a endoscopic treatment was successful and Group 2: Patients in whom other approaches were needed after endoscopic treatment failure. The possible relationship between the UWT values and other radiological parameter with the outcomes of endoscopic treatment was comparatively evaluated.
All patients developed ureteral stricture due to upper ureteral stones with ureteroscopic laser disintegration. No significant difference was present regarding the patient characteristics. Mean UWT value assessed at the treated stone site was significantly higher in cases unresponsive to endoscopic treatment with values of 2.77±1.03 mm and 4.25±1.32 mm in Group 1 and 2 respectively. A cut off value 3.55 mm for UWT was found to be highly predictive for endoscopic treatment failure.
Our current results indicated that assessment of UWT value at the obstructing stone could be helpful enough to predict the likelihood of failure following endoscopic management of strictures with high sensitivity and specifity. Evaluation of this particular parameter could let the endourologists to look for more rational treatment alternatives with necessary mesaures taken on time.
Clinical comparative study of transumbilical laparoendoscopic single-site surgery versus conventional laparoscopic surgery for patients with fallopian pregnancy
Authors: Han Ling , Zhang Bingyi 
Published: October 2023

Abstract
Object:
The Body Image Questionnaire (BIQ) score was introduced to objectively evaluate the aesthetic effects of single and porous laparoscopic salpingectomy.
Methods:
A total of 40 patients undergoing single-port laparoscopic salpingectomy for fallopian pregnancy admitted to People's Hospital of China Three Gorges University from January 2019 to July 2021 were enrolled, and 38 patients undergoing conventional laparoscopic surgery for the same disease were selected as the control group. Visual Analogue Scale (VAS) at 24 hours after surgery and BIQ were used to evaluate patients' body satisfaction and cosmetic satisfaction of postoperative wound scar.
Results:
here was no significant difference in the mean age, Body mass index (BMI), history of previous abdominal surgery, pelvic adhesion, Visual analogue score of pain at 24 h postoperatively, postoperative pain drug use, and Body Image Scale（BIS）score between the two groups. Two groups of patients with postoperative fever, intraoperative blood loss, postoperative 24 hours Hb decreased, total length of hospital stay, there was no statistically significant difference. However, there were statistical differences between the two groups in postoperative cosmetic score, total hospitalization cost, and operation time.
Conclusion:
Single port laparoscopic salpingectomy is safe and feasible and has certain advantages inincision beauty and incision pain.
Dose Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood Brain Barrier Permeability Following Traumatic Brain Injury: An In-vivo Murine Study
Authors: Culkin Matthew C , Bele Priyanka , Georges Anastasia P , Carlin Patricia Santos , Niziolek Grace , Kaplan Lewis J , Smith Douglas H , L Jose L Pascual 
Published: October 2023

Abstract
Background. Early post-TBI Tranexamic acid (TXA) may reduce blood-brain-barrier (BBB) permeability, but it is unclear if this effect is fixed regardless of dose. We hypothesized that post-TBI TXA demonstrates a dose dependent reduction of in vivopenumbral leukocyte (LEU) mobilization, BBB microvascular permeability, and enhanced neuroclinical recovery.
Study Design. CD1 male mice (n=40) were randomized to TBI by controlled cortical impact (Injury, I) or sham craniotomy (S), followed by IV bolus of either saline (placebo, P) or TXA (15, 30, or 60mg/kg). At 48h, in-vivo pial intravital microscopy (IVM) visualized live penumbral BBB microvascular LEUs and albumin leakage. Neuroclinical recovery was assessed by Garcia Neurological Test (GNT) scores and animal weight changes at 24 and 48h after injury.
Results.I+TXA60 reduced live penumbral LEU rolling compared to I+P (p<0.001) and both lower TXA doses (p=0.017 vs. I+TXA15, p=0.012 vs. I+TXA30). LEU adhesion was infrequent and similar across groups. Only I+TXA60 significantly reduced BBB permeability compared to I+P (p=0.004). All TXA doses improved GNT scores relative to I+P at both 24 and 48h (p<0.001 vs. I+P for all at both time points). Mean 24-hour body weight loss was greatest in I+P (-8.7±1.3%) and lowest in TXA15 (-4.4±1.0%, p=0.051 vs. I+P).
Conclusion. Only higher TXA dosing definitively abrogates penumbral LEU mobilization, preserving BBB integrity post-TBI. Some neuroclinical recovery is observed even with lower TXA dosing. Better outcomes with higher dose TXA after TBI may occur secondary to LEU-mediated penumbral cerebrovascular inflammation blunting.
Protective effects of metformin against doxorubicin-induced hepatoxicity in rats
Authors: lal-Shahsavar Shabnam , Zolbanin Naime Majidi , Jafari Abbas , Ghasemnejad-Berenji Morteza 
Published: October 2023

Abstract
Purpose
Doxorubicin (DOX) is one of the most commonly prescribed anti-cancer drugs. However, DOX-induced hepatotoxicity is a dose-limiting side effect. This study aimed to clarify the potential protective effects of metformin on DOX-induced hepatotoxicity in rats.
Methods
The animals were divided into six groups (n=6 each): Control Group, DOX group, metformin 200 mg/kg group, DOX + metformin 50 mg/kg group, DOX + metformin 100 mg/kg group, and DOX + metformin 200 mg/kg group. Hepatic injury was induced by a single intraperitoneal injection of DOX (20mg/kg). The activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in serum were determined. Furthermore, the hepatic histopathological changes were evaluated. In order to identify the markers of oxidative stress, the level of malondialdehyde (MDA) and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver tissue were measured.
Results
Results showed that DOX provoked a marked elevation in ALT, AST, and ALP serum levels. In addition, oxidative stress was significantly boosted in DOX-treated rats compared to control rats. All these were abolished with the metformin administration. Histological examination also showed that metformin could significantly reduce DOX-induced alterations. The most prominent effect was observed by high-dose metformin.
Conclusion
This study showed that metformin could prevent doxorubicin-induced hepatoxicity.
Controllable preparation of Zeolite-P/calcined diatomite with MgCl2
Authors: Guo Zhengzheng , Ren Zijie , Gao Huimin , Guan Junfang , Li Peiyue , Zheng Renji , Yin Hang , Chen Zhijie 
Published: October 2023

Abstract
Developing highly efficient calcined diatomite (C-D)-based filter aids with excellent adsorption performance is of great significance. Herein, Zeolite-P was successfully synthesized on the surface of C-D through hydrothermal modification with NaOH and MgCl2 as efficient morphology control agents. The optimal Zeolite-P/C-D material perfectly retained the diatomite structure and showed a whiteness of 83.36% and a high specific surface area of 237.47 m2/g, leading to an excellent adsorption capacity for methylene blue trihydrate (MB) of 125.46 mg/g and a good permeability of 0.43 darcy. The porous fibrous microspheres Zeolite-P was synthesized on the surface of C-D under controlled conditions to improve the adsorption performance of Zeolite-P/C-D material. By developing diatomite-based composites for filter aids applications, this study paves the way for the comprehensive and efficient utilization of low-cost diatomite resources.
Genetic dissection and identification of stripe rust resistance genes in the wheat cultivar Lanhangxuan 121, a cultivar selected from a space mutation population
Authors: Wu Qimeng , Liu Lei , Zhang Dandan , Li Chenchen , Nie Ruiqi , Duan Jiangli , Wan Jufen , Zhao Jiwen , Cao Jianghao , Liu Dan , Liu Shengjie , Wang Qilin , Zheng Weijun , Yao Qiang , Kang Zhensheng , Zhang Wentao , Du Jiuyuan , Han Dejun , Wang Changfa , Wu Jianhui , Li Chunlian 
Published: October 2023

Abstract
Stripe rust is a devastating disease of wheat worldwide. Chinese wheat cultivar Lanhangxuan 121 (LHX121), selected from an advanced line L92-47 population that had been subjected to space mutation breeding displayed a consistently higher level of resistance to stipe rust than its parent in multiple field environments. The aim of this research was to establish the number and types of resistance genes L92-47 and LHX121 using separate segregating populations. The first population developed from a cross between LHX121 and susceptible cultivar Xinong 822 comprised 278 F2:3 lines. The second validation population comprised 301 F2:3 lines from a cross between L92-47 and susceptible cultivar Xinong 979. These lines were evaluated for stripe rust response at three sites during the 2018-2020 cropping season. Affymetrix 660K SNP arrays were used to genotype the lines and parents. Inclusive composite interval mapping detected QTL QYrLHX.nwafu-2BS, QYrLHX.nwafu-3BS, and QYrLHX.nwafu-5BS for resistance in all three environments. Based on previous studies and pedigree information, QYrLHX.nwafu-2BS and QYrLHX.nwafu-3BS were likely to be Yr27 and Yr30 that are present in the L92-47 parent. QYrLHX.nwafu-5BS (YrL121) detected only in LHX121 was mapped to a 7.60 cM interval and explained 10.67-22.57% of the phenotypic variation. Compared to stripe rust resistance genes previously mapped to chromosome 5B, YrL121 might be a new adult plant resistance QTL. Further, there were a number of variations signals using 35K SNP array and differentially expressed genes using RNA-seq between L92-47 and LHX121 in the YrL121 region, indicating that they probably impair the presence and/or function of YrL121.
Fluctuating selection at work: Estimating the firms’ fitnesses from time series of their market caps and forecasting their future shares
Authors: Fort Hugo 
Published: October 2023

Abstract

Evolutionary economics has been useful to explain the nature of the processes of innovation, as well as providing useful heuristics for applied research. However, quantitative tests are rare and in general fail to capture the observed dynamics of firms in real markets. A main problem is how to estimate the fitnesses of companies. We present a quantitative implementation of fluctuating selection to explain and forecast the dynamics of firms’ market capitalizations (MC). We start by proposing a recipe to estimate the financial fitness of a company from its MC time series, which is completely analogous to the Malthusian fitness of evolutionary biology. Using Malthusian fitnesses in terms of MC implies that all companies, through their stocks, irrespective of their industry or sector, are competing for investors’ money. These fitnesses, in turn, allow to forecast the companies’ proportions of total MC through a natural selection equation. We validate the method using the daily MC of public-owned Fortune 100 companies across 2000–2021. This Fluctuating Selection from Market Capitalization (FSMC) formula is particularly accurate in forecasting the MC proportions of companies. It outperforms the geometric random walk stochastic benchmark for all forecasting instances across validation periods ranging from a month to a year.JEL codes: B52, C51, C52, C53, C63, G17
Prolonged corticosteroid regimen with slow monthly tapering course is effective for the initial episode of steroid sensitive nephrotic syndrome; Evidence from a Randomized control trial
Authors: Udupitikankanange Jayantha , Randula Sithira , Darshana Nuwan 
Published: October 2023

Abstract
Background
The benefits of prolonged steroid therapy in the initial episode Steroid Sensitive Nephrotic Syndrome (SSNS) has been challenged. This study was conducted to determine whether prolonged corticosteroid regimen for the initial episode of SSNS resulting in highly favorable results with slow monthly tapering course against prolonged regimen with steep dose reduction and rapid tapering course.
Methods
A randomized control trial was conducted among 65 children aged 1-12years with nephrotic syndrome after achieve remission with daily prednisolone for 28 days. They were randomized into two groups based on prednisolone regimen; Author Experimental Regimen (AER)(n = 32) and Kidney Disease Improving Global outcome (KDIGO)(n = 33) regimen. AER group (total 7 months) received a prolonged prednisolone regimen with slow monthly tapering course. KDIGO regimen group received prolonged regimen with steep dose reduction and rapid tapering course. Both groups were followed up to three years at 6-month, 12-month, 24 month and 36 months respectively.
Results
The mean (SD) duration of remission following the initial episode was significantly prolonged in the AER group compared to the KDIGO group (17.3 vs 8.4 months). Relapse rate, relative risk for relapse, cumulative relapse status and incidence of steroid dependence were statistically significantly very low in AER group. Children in AER group had lower risk to develop adverse events due to steroid therapy.
Conclusion
The prolonged corticosteroid regime with a slow monthly tapering course showed a highly favorable results for the initial episode of SSNS. Hence, AER is recommended to manage children with initial episode of SSNS to achieve better outcome.
The gut microbiota and psoriasis: A two-sample Mendelian randomization study Running title: Gut microbiota and psoriasis
Authors: Guo Chenqi , Li Junchen , Zhang Jianfeng , Xu Fan , Wang Yingdong , Gu Xiangru , Zhang Min , Zhang Yu 
Published: October 2023

Abstract

Background
Increasing evidence suggests an association between the gut microbiota and psoriasis, but the causal relationship between them is not yet clear.
Methods
To explore the relationship between the gut microbiome (GM) and psoriasis, a bidirectional dual-sample Mendelian randomization (MR) study was conducted. The genome-wide association study (GWAS) summary statistics of the gut microbiota and psoriasis were obtained from the most extensive GWAS database. We used maximum likelihood (ML), MR Egger regression, weighted median, inverse variance weighting (IVW), and weighted models to study the causal relationship between the gut microbiota and psoriasis. Then, sensitivity analyses such as level multiple validity analysis, Cochran’s Q test, and the retention method were used to evaluate the reliability of the results.
Results
MR analysis revealed that the class Mollicutes (OR = 1.003, 95% CI = 1.001–1.006, P = 0.004019), genus Lachnospiraceae FCS020 group (OR = 1.003, 95% CI = 1.000-1.005, P = 0.04076), and phylum Tenericutes (OR = 1.003, 95% CI = 1.001–1.006, P = 0.004019) were causally associated with an increased risk of psoriasis. The family Victivallaceae (OR = 0.998, 95% CI = 0.997-1.000, P = 0.005296) and order Pasteurellales(OR = 0.998, 95% CI = 0.996 -1.000, P = 0.047) were also linked to a decreased risk of psoriasis. The results of the sensitivity analysis were robust. There is no evidence of a reverse causal relationship from psoriasis to the identified bacterial taxa found in the results of reverse MR analysis results.
Conclusion: Our study comprehensively evaluated the potential causal relationship between the gut microbiota and psoriasis, demonstrating that specific gut microbiota can affect the development of psoriasis and providing new directions for future prevention and treatment of psoriasis.
Requirements Business Value and Test Case Attributes based Test Case Prioritization Using Deep Reinforcement Learning.
Authors: Khan Tamim Ahmed , Akhtar Zobia Jabeen 
Published: October 2023

Abstract
Testing is a cost-intensive process whereas regression testing is used for the purpose of finding out if there is a regression in a post-evolution or post-maintenance scenario. It is expensive to run all test cases for regression testing and therefore we require a test case selection strategy so that we may select a subset of test cases from a previously available set of all test cases. Test case prioritization is a mechanism that can be used as a test subset selection strategy for regression testing. We investigate how requirements priority and importance as well as test case parameters such as fault severity, fault count, and their inter-dependency can be used for proposing a reward function to improve results. We use a deep reinforcement learning approach to optimize or prioritize the test cases using our reward function. We make use of an off-policy, model-free, and value-based test case prioritization approach considering a deep Q-Network (DQN) agent and a reward system based on a business value of test cases that prioritize the test cases against those business values. We use performance metrics to measure the performance and effectiveness of our research. We have compared our results with the published research and conclude that the results achieved from our approach outperform the previously published results of state-of-the-art studies.