bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human papillomavirus infection affects treatment outcomes and the immune microenvironment in patients with advanced penile squamous cell carcinoma receiving programmed cell death protein 1 inhibitor–based combination therapy
Authors: Wei Lichao , Li Zaishang , Guo Shengjie , Ma Huali , Shi Yanxia , An Xin , Huang Kangbo , Xiong Longbin , Xue Ting , Zhang Zhiling , Yao Kai , Luo Junhang , Han Hui 
Published: December 2023

AbstractBackgroundPenile squamous cell carcinoma (PSCC) is a human papillomavirus (HPV)‐associated malignancy. Immunotherapy is emerging as a potential treatment for advanced PSCC. In this study, the authors analyzed the association of HPV status with outcomes and the immune microenvironment in patients with advanced PSCC undergoing programmed cell death protein 1 (PD1) inhibitor–based combination therapy (PCT).MethodsHPV status was assessed using quantitative polymerase chain reaction in 87 patients with advanced PSCC treated with PCT. Objective response rate (ORR), disease control rate (DCR), progression‐free survival (PFS), and overall survival (OS) in the HPV+ and HPV– groups were compared. Additionally, bulk RNA sequencing was performed to investigate the potential impact of HPV on the immune microenvironment in advanced PSCC.ResultsAmong patients receiving first‐line PCT, ORR (91.7% vs. 64.6%, p = .014) and DCR (100.0% vs. 79.2%, p = .025) in the HPV+ group were higher compared to the HPV– group. Kaplan–Meier curves demonstrated that the HPV+ group exhibited superior PFS (p = .005) and OS (p = .004) for patients in the first‐line setting. However, these advantages of HPV infection were not observed in multi‐line PCT (p > .050). HPV status remained an independent prognostic factor for predicting better ORR (p = .024), PFS (p = .002), and OS (p = .020) in the multivariate analyses. Landmark analyses showed that the HPV‐induced superiority of PFS occurred at an early stage (within 3 months) and OS occurred at a relatively late stage (within 9 months). Bioinformatic analyses identified potential immune‐activated genes (GLDC, CYP4F12, etc.) and pathways (RAGE, PI3K/AKT, etc.), antitumor immune cell subtypes, and lower tumor immune dysfunction and exclusion scores in HPV+ tissues.ConclusionsHPV infection may confer treatment efficacy and survival benefits in patients with advanced PSCC receiving first‐line PCT because of the possible stimulation of the antitumor immune microenvironment.Plain Language Summary

Human papillomavirus (HPV) infection may induce better objective response rate, progression‐free survival (PFS), and overall survival (OS) for advanced penile squamous cell carcinoma (PSCC) patients receiving first‐line programmed cell death protein 1 inhibitor–based combination therapy (PCT) instead of multi‐line PCT.
HPV infection‐induced PFS advantage occurs at an early stage (within 3 months) whereas OS superiority occurs at a relatively late stage (within 9 months).
Antitumor immune microenvironment could be stimulated by HPV infection in advanced PSCC tissues.
In‐Situ Colloidal Synthetic Route to Monodispersed NiCo2S4 Nanoparticles over Nickel Foam for High‐Performance Supercapacitive Charge Storage
Authors: Wang Ye , Yu Junling , Yang Fengyi , Yang Qing 
Published: December 2023

AbstractOne‐step colloidal synthetic route was adopted to in‐situ grow monodispersed NiCo2S4 nanoparticles (NPs) on nickel foam (NF) from metallic salts with benzyl disulfide in the media of oleylamine and octadecene. Owing to the favorable dispersion and considerable redox activity of NiCo2S4 along with tight and binder‐free connection with NF, the obtained battery‐type supercapacitor delivered a specific capacitance of 1790.8 F g−1 at 1 A g−1 via a three‐electrode system. Simultaneously, it just degraded 40 % at 20 A g−1 and maintained 86.8 % of initial specific capacitance (C0) after 2000 cyclic trials at 10 A g−1. When the NiCo2S4 NPs were assembled with active carbon (AC) forming an asymmetric capacitor device of NiCo2S4 NPs//AC, it delivered an energy density (E) of 48.7 W h kg−1 at a power density (P) of 161.1 W kg−1, and kept 21.9 W h kg−1 at a high P of 8.05 kW kg−1. Meanwhile, the capacitor manifested preeminent cycling life (C=94.5 % C0 after 5000 cyclic trials) at 5 A g−1. The in‐situ grown NiCo2S4 NPs on NF without any binder exhibited high performance in energy storage, providing a feasible way to improve the electrochemical performance of the electrode materials.
A robust transformer GAN for unpaired data makeup transfer
Authors: Chen Yan , Xie Jiajian , Xue Jiajun , Wang Hui 
Published: December 2023

SummaryThe objective of makeup transfer is to apply the makeup style of, thereby creating the similar appearance as if it was professionally done. This technique has significant practical applications in fashion, beauty, and video special effects industries. However, there are several challenges faced by current makeup transfer models: (1) Low‐resolution images can only achieve partial makeup transfer in mainstream models. (2) Difficulty arises in obtaining paired data consisting of both makeup and non‐makeup images. (3) Spatial displacement occurs due to differences in subject and pose between reference and source images, affecting corresponding feature regions. (4) Mainstream models primarily focus on local feature characteristics while lacking global feature perception. To address these challenges, this paper proposes a nonpaired data makeup transfer model based on swin transformer generative adversarial networks. Additionally, an improved progressive generative adversarial network model (PSC‐GAN), incorporating semantic perception and channel attention mechanisms, is proposed to enhance the effectiveness of makeup transfer.
Production rates and destruction frequencies of ammonia in inductively coupled H2O/N2 and H2/N2 plasmas
Authors: Takahashi Jin , Sasaki Koichi 
Published: December 2023

AbstractWe compared the production rates and the destruction frequencies of ammonia in inductively coupled H2O/N2 and H2/N2 plasmas. We observed that the production rates of ammonia ranged between 4 and 7 μmol/s both in the H2O/N2 and H2/N2 plasmas generated at rf powers between 100 and 160 W, corresponding to the energy cost of 23–25 mol/MJ. Almost the same production rates suggest the usefulness of H2O as the resource for hydrogenation of atomic nitrogen adsorbed on surfaces. On the other hand, the destruction frequency was 2–4 times higher in the H2O/N2 than H2/N2 plasmas. Although the H2O/N2 plasma has a drawback in the destruction frequency, the present work shows its potential for the direct synthesis of ammonia from water with skipping the production of hydrogen.
Mukherjee, Souvik. 2022. Videogames in the Indian Subcontinent. Development, Culture(s) and Representations. Bloomsbury
Authors: Zeiler Xenia 
Published: December 2023

AbstractThe book Videogames in the Indian Subcontinent. Development, Culture(s) and Representations is the first ever comprehensive presentation and discussion of material spanning over all nations of South Asia, including Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka. Discussed by the leading expert on the theme, it offers both an overview of as well as numerous detailed examples of both, historical and contemporary developments. Appropriately, this work also situates the regional characteristics in larger global contexts and cultural flows, and contemporary developments in historical contexts.
Embryonic development of the neotropical pit viper Bothrops atrox (Serpentes: Viperidae: Crotalinae), with emphasis on pit organ morphogenesis and its evolution in snakes
Authors: Silva Fernanda Magalhães , Guerra‐Fuentes Ricardo Arturo , Blackburn David C. , Prudente Ana L. Costa 
Published: December 2023

AbstractBackgroundBothrops atrox is a pit viper with a loreal pit organ, and its embryological development remains undescribed. Here, we provide a comprehensive description of the embryology of B. atrox, focusing on the loreal pit organ and cephalic scales.ResultsWe characterized 13 developmental stages of B. atrox based on external features consistent with the embryogenesis of previously described snake species. The loreal pit organ originates from the circumorbital region and migrates to its final position. In Crotalinae, the pit organ first becomes visible at stage 28, whereas in Pythonidae labial, pit organs appear at Stage 35. Pit organs evolved independently three times in Serpentes, encompassing Boidae, Pythonidae, and Crotalinae. Boidae lacks embryological information for pit organs. Furthermore, we observed that head scalation onset occurs at Stage 33 in B. atrox, with fusion of scales surrounding the loreal pit organ.ConclusionsThe embryology of pit organs in Pythonidae and Boidae species remains poorly understood. Our detailed embryological descriptions are critical for proposing developmental scenarios for pit organs and guiding future research on these structures.
Clinical phenogroup diversity and multiplicity: Impact on mechanisms of exercise intolerance in heart failure with preserved ejection fraction
Authors: Larson Kathryn , Omar Massar , Sorimachi Hidemi , Omote Kazunori , Alogna Alessio , Popovic Dejana , Tada Atsushi , Doi Shunichi , Naser Jwan , Reddy Yogesh N.V. , Redfield Margaret M. , Borlaug Barry A. 
Published: December 2023

AbstractAimsWe aimed to clarify the extent to which cardiac and peripheral impairments to oxygen delivery and utilization contribute to exercise intolerance and risk for adverse events, and how this relates to diversity and multiplicity in pathophysiologic traits.Methods and resultsIndividuals with heart failure with preserved ejection fraction (HFpEF) and non‐cardiac dyspnoea (controls) underwent invasive cardiopulmonary exercise testing and clinical follow‐up. Haemodynamics and oxygen transport responses were compared. HFpEF patients were then categorized a priori into previously‐proposed, non‐exclusive descriptive clinical trait phenogroups, including cardiometabolic, pulmonary vascular disease, left atrial myopathy, and vascular stiffening phenogroups based on clinical and haemodynamic profiles to contrast pathophysiology and clinical risk. Overall, patients with HFpEF (n = 643) had impaired cardiac output reserve with exercise (2.3 vs. 2.8 L/min, p = 0.025) and greater reliance on peripheral oxygen extraction augmentation (4.5 vs. 3.8 ml/dl, p < 0.001) compared to dyspnoeic controls (n = 219). Most (94%) patients with HFpEF met criteria for at least one clinical phenogroup, and 67% fulfilled criteria for multiple overlapping phenogroups. There was greater impairment in peripheral limitations in the cardiometabolic group and greater cardiac output limitations and higher pulmonary vascular resistance during exertion in the other phenogroups. Increasing trait multiplicity within a given patient was associated with worse exercise haemodynamics, poorer exercise capacity, lower cardiac output reserve, and greater risk for heart failure hospitalization or death (hazard ratio 1.74, 95% confidence interval 1.08–2.79 for 0–1 vs. ≥2 phenogroup traits present).ConclusionsThough cardiac output response to exercise is limited in patients with HFpEF compared to those with non‐cardiac dyspnoea, the relative contributions of cardiac and peripheral limitations vary with differing numbers and types of clinical phenotypic traits present. Patients fulfilling criteria for greater multiplicity and diversity of HFpEF phenogroup traits have poorer exercise capacity, worsening haemodynamic perturbations, and greater risk for adverse outcome.
Research on high efficiency and retarded autogenous mud acid for plugging removal in a sandstone reservoir—Example of Bai 823 well area
Authors: Li Huan , Yang Shuai , Li Guoliang , Yang Tingting , Fu Haoran 
Published: December 2023

AbstractAcidification, as an effective measure to remove blockages and restore oil well productivity, has received widespread concern. However, conventional acid systems can only be used to unblock near‐wellbore zones and are difficult to act on far‐wellbore reservoirs. In this article, scanning electron microscope, energy‐dispersive X‐ray spectroscope, and X‐ray diffractometer were used to analyze the blockages in the Bai 823 well area, and it was determined that their main components were CaCO3 and FeCO3, which provided the basis for the construction of the unblocking formula. Then, the acid dissolution experiments on the plugging materials showed that the dissolution rate of 10% HCl can reach more than 85% for the scale sample; the acid dissolution experiments on the rock sample showed that the autogenous mud acid has better dissolution performance and better retardation performance for the rock sample, and the effective action time is longer, so it can be used for deeper unplugging of the reservoir. Finally, the process parameters such as the optimal acid concentration, acid dosage, and discharge volume were optimized by establishing the fracture‐matrix acid flow reaction model. Research results indicate that the autogenous mud acid can act on the blockage in the far‐wellbore area to improve the acidification effect.
Electric machine sizing consideration for ePumps in mobile hydraulics
Authors: Assaf Hassan , Sarode Shanmukh , Vacca Andrea , Sudhoff Scott D. 
Published: December 2023

AbstractEnvironmental concerns have pushed toward electrified technologies for off‐road vehicle actuations that can lower greenhouse gas emissions and reduce energy consumption. Replacing a central diesel engine with a dedicated electric machine (EM) as a prime mover for the hydraulic supply offers several opportunities for so‐called ePumps (aka electric‐driven pumps) to maximize energy efficiency and limit the usage of electric materials. This paper discusses the impact of different choices for the ePumps architecture (i.e., fixed vs. variable displacement pump; variable speed vs. fixed speed electrical machine), and on their main design parameters in terms of size and efficiency. Although the procedure followed in the study could be extended to different types of electric and hydraulic units, the paper particularly considers ePumps based on permanent magnet synchronous machines combined with axial piston machines. The importance of properly considering the ePump drive cycle and its cooling requirements is taken into account while addressing energy efficiency, mass, and overall compactness of the solution. The results show that an ePump based on a variable displacement pump, when compared to fixed displacement ePumps, reduces the electrical machine size both in volume and mass up to 40%, when the high‐pressure demand is not combined with high flow rate demand, thus decreasing the cost of the EM. In all drive cycles, the variable speed EM–fixed displacement pump architecture has a higher efficiency, ranging from 1% to 5%, compared to the case of fixed speed EM–variable displacement pump. Finally, the paper compares the advantages and shortcomings of each ePump architecture presented, based on representative drive cycles.
Performance evaluation of CO2 capture on using potential adsorbents in a CI engine exhaust–An experimental investigation
Authors: Ravi Maniarasu , Rathore Sushil Kumar , Sivalingam Murugan 
Published: December 2023

AbstractAnthropogenic activites release greenhouse gas emissions into our atmosphere, especially carbon dioxide (CO2). This abundant accumulation of CO2 generates numerous problems like global warming and climate change. However, research has been conducted to capture CO2 from significant single‐point emitters like compression ignition (CI) engines, backup generators, and distributed power production plants. Moreover, research has also been done on post‐combustion adsorption chamber to capture CO2 emissions from small stationary engines. Biomass‐based activated carbon as an adsorbent for capturing CO2 from engine exhaust has recently been investigated. Three biomass‐based adsorbents, (a) coconut shell adsorbent, (b) rice husk adsorbent and (c) eucalyptus wood adsorbent, are used in the capture unit to trap CO2 from the CI engine exhaust. This study uses a single‐cylinder, four‐stroke, air‐cooled, naturally‐aspirated, direct‐injection (DI) CI engine running at a constant speed of 1,500 rpm and producing power of 4.4 kW. The adsorption performance of adsorbent samples is investigated by coupling the adsorption chamber to the exhaust system of a test engine operated on diesel (D100) at various loads. Temperature swing adsorption (TSA) is used to regenerate the original adsorbent. The adsorbents’ adsorption capacities are evaluated by performing multiple adsorption–desorption test cycles using the same adsorbents. During TSA, CO2 released from the capture unit is further captured and stored in a gas bag. The captured gas sample is characterized through gas chromatography‐mass spectroscopy (GC‐MS) characterization to examine and ensure the gas adsorption efficacy of adsorbent samples. The outcomes of this research study are discussed and presented in detail. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
Chiral Quaternary Ammonium Salt‐Catalyzed Enantioselective Addition Reactions of Hydantoins
Authors: Röser Katharina , Prameshuber Lucas , Jahangir Sajid , Chandra Mallojjala Sharath , Hirschi Jennifer S. , Waser Mario 
Published: December 2023

AbstractWe herein report a protocol for the asymmetric 1,4‐addition of hydantoins to various Michael acceptors by utilizing Cinchona alkaloid‐based chiral quaternary ammonium salt catalysts. Various products were obtained with moderate to good enantioselectivities and accompanying computational investigations helped to identify key interactions responsible for the observed selectivity. DFT calculations along with non‐covalent interaction plots reveal the presence of numerous stabilizing non‐classical hydrogen bonding interactions along with other non‐covalent interactions between the chiral quaternary ammonium salt and hydantoin molecule in the C−C bond forming transition states leading to the formation of the products. In addition, a first proof‐of‐concept for an analogous a‐sulfanylation reaction, albeit with poor selectivity, is reported as well.
Sonographic features of diffuse giant cell tumor of the tendon sheath in the shoulder: A case report
Authors: Du Yan , Li Li , Hu Xiaoling 
Published: December 2023

AbstractA middle‐aged woman presented to our hospital with a chief complaint of a mass on the left shoulder for 1 year. The initial lump was small with no pain or tenderness, and the patient had not sought medical attention for numbness in the left shoulder. Clinical examination showed a mass on the left shoulder measuring 11 × 8 × 3 cm approximately with no apparent skin damage or ecchymosis. No limitations in left shoulder joint movements were observed, and the patient exhibited normal movement of the left elbow joint, wrist joint, and metacarpophalangeal joint. Moreover, the left radial artery was palpable.
Evaluation of antioxidant, antityrosinase, and anticancer activity of mucus extract from both Egyptian land snails, Eremina desertorum and Helix aspersa, with emphasis on their chemical profiles
Authors: Kandeil Manar A. , Mona Mahy M. 
Published: December 2023

AbstractThe snail mucus provides several functions and is increasingly being exploited for medicinal and cosmetic purposes. This study aimed to determine the chemical profile of two snail mucus extracts: the garden snail (Helix aspersa) and the desert snail (Eremina desertorum). In addition, it elucidates the antityrosinase, antioxidant, and anticancer activities against the human cancer cell line epithelioid carcinoma (Hela). The mucus was extracted from the pedal glands of garden snails (H. aspersa) and desert snails (E. desertorum). 2,2‐Diphenyl‐1‐picrylhydrazyl assay and the content of catalase, glutathione‐S‐transferase, superoxide dismutase, and reduced glutathione were utilized to assess the antioxidative screening activity of the mucus extracts. Besides a tyrosinase inhibitor assay, anticancer activity on cervical cancer cells (Hela) was studied. Additionally, the two mucus samples' total protein, total lipid, fatty acid, and amino acid profiles were compared. The mucus from both snails exhibited antioxidant activity. E. desertorum is more effective in inhibiting tyrosinase activity and has better scavenging activity than H. aspersa mucus extract. Both extracts revealed inhibitory activity against Hela cells, with insignificant differences. Moreover, the results indicated higher protein, lipids, and fatty acids mucus content of E. desertorum extract than those of H. aspersa mucus extract. Both snail slimes' obtained different biological activities, and amino acid contents could be related to their specific functions and beneficial for medical applications, especially antihyperpigmentation.
Long‐term outcomes of neoadjuvant gemcitabine, nab‐paclitaxel, and S1 (GAS) in borderline resectable pancreatic cancer with arterial contact: Results from a phase II trial
Authors: Uemura Kenichiro , Kondo Naru , Sudo Takeshi , Sumiyoshi Tatsuaki , Shintakuya Ryuta , Okada Kenjiro , Baba Kenta , Harada Takumi , Murakami Yoshiaki , Takahashi Shinya 
Published: December 2023

AbstractBackground/PurposeThis study reports the long‐term results of a phase II trial evaluating the clinical efficacy of neoadjuvant gemcitabine, nab‐paclitaxel, and S1 (GAS) in borderline resectable pancreatic cancer with arterial contact (BRPC‐A).MethodsA multicenter, single‐arm, phase II trial was conducted. Patients received six cycles of GAS and patients without progressive disease were intended for R0 resection.ResultsOf the 47 patients, 45 (96%) underwent pancreatectomy. At the time of this analysis, all patients were updated with no loss to follow‐up. A total of 30 patients died, while the remaining 17 patients were followed for a median of 68.1 months. The updated median overall survival (OS) was 41.0 months, with 2‐ and 5‐year OS rates of 68.0% and 44.6%, respectively. Multivariate analysis in the preoperative model showed that a tumor diameter reduction rate ≥10% and a CA19‐9 reduction rate ≥95% after neoadjuvant chemotherapy remained independently associated with favorable survival. In the postoperative multivariate model, no lymph node metastasis, no major surgical complications, and completion of adjuvant chemotherapy were independently associated with improved OS.ConclusionsThis long‐term evaluation of the neoadjuvant GAS trial demonstrated the high efficacy of the regimen, suggesting that it is a promising treatment option for patients with BRPC‐A.
Accelerated Musculoskeletal Magnetic Resonance Imaging
Authors: Yoon Min A , Gold Garry E. , Chaudhari Akshay S. 
Published: December 2023

With a substantial growth in the use of musculoskeletal MRI, there has been a growing need to improve MRI workflow, and faster imaging has been suggested as one of the solutions for a more efficient examination process. Consequently, there have been considerable advances in accelerated MRI scanning methods. This article aims to review the basic principles and applications of accelerated musculoskeletal MRI techniques including widely used conventional acceleration methods, more advanced deep learning‐based techniques, and new approaches to reduce scan time. Specifically, conventional accelerated MRI techniques, including parallel imaging, compressed sensing, and simultaneous multislice imaging, and deep learning‐based accelerated MRI techniques, including undersampled MR image reconstruction, super‐resolution imaging, artifact correction, and generation of unacquired contrast images, are discussed. Finally, new approaches to reduce scan time, including synthetic MRI, novel sequences, and new coil setups and designs, are also reviewed. We believe that a deep understanding of these fast MRI techniques and proper use of combined acceleration methods will synergistically improve scan time and MRI workflow in daily practice.Evidence Level3Technical EfficacyStage 1