bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond MEN1, When to Think About MEN4? Retrospective Study on 5600 Patients in the French Population and Literature Review
Authors: Chevalier Benjamin , Coppin Lucie , Romanet Pauline , Cuny Thomas , Maïza Jean-Christophe , Abeillon Juliette , Forestier Julien , Walter Thomas , Gilly Olivier , Le Bras Maëlle , Smati Sarra , Nunes Marie Laure , Geslot Aurore , Grunenwald Solange , Mouly Céline , Arnault Gwenaelle , Wagner Kathy , Koumakis Eugénie , Cortet-Rudelli Christine , Merlen Émilie , Jannin Arnaud , Espiard Stéphanie , Morange Isabelle , Baudin Éric , Cavaille Mathias , Tauveron Igor , Teissier Marie-Pierre , Borson-Chazot Françoise , Mirebeau-Prunier Delphine , Savagner Frédérique , Pasmant Éric , Giraud Sophie , Vantyghem Marie-Christine , Goudet Pierre , Barlier Anne , Cardot-Bauters Catherine , Odou Marie Françoise 
Published: January 2024

Abstract

Context
Germline CDKN1B variants predispose patients to multiple endocrine neoplasia type 4 (MEN4), a rare MEN1-like syndrome, with &lt;100 reported cases since its discovery in 2006. Although CDKN1B mutations are frequently suggested to explain cases of genetically negative MEN1, the prevalence and phenotype of MEN4 patients is poorly known, and genetic counseling is unclear.

Objective
To evaluate the prevalence of MEN4 in MEN1-suspected patients and characterize the phenotype of MEN4 patients.

Design
Retrospective observational nationwide study. Narrative review of literature and variant class reassessment.

Patients
We included all adult patients with class 3/4/5 CDKN1B variants identified by the laboratories from the French Oncogenetic Network on Neuroendocrine Tumors network between 2015 and 2022 through germline genetic testing for MEN1 suspicion. After class reassessment, we compared the phenotype of symptomatic patients with class 4/5 CDKN1B variants (ie, with genetically confirmed MEN4 diagnosis) in our series and in literature with 66 matched MEN1 patients from the UMD-MEN1 database.

Results
From 5600 MEN1-suspected patients analyzed, 4 with class 4/5 CDKN1B variant were found (0.07%). They presented with multiple duodenal NET, primary hyperparathyroidism (PHPT) and adrenal nodule, isolated PHPT, PHPT, and pancreatic neuroendocrine tumor. We listed 29 patients with CDKN1B class 4/5 variants from the literature. Compared with matched MEN1 patients, MEN4 patients presented lower NET incidence and older age at PHPT diagnosis.

Conclusion
The prevalence of MEN4 is low. PHPT and pituitary adenoma represent the main associated lesions, NETs are rare. Our results suggest a milder and later phenotype than in MEN1. Our observations will help to improve genetic counseling and management of MEN4 families.
Modifications of the GH Axis Reveal Unique Sexually Dimorphic Liver Signatures for Lcn13, Asns, Hamp2, Hao2, and Pgc1a
Authors: Brie Belen , Sarmento-Cabral Andre , Pascual Florencia , Cordoba-Chacon Jose , Kineman Rhonda Denise , Becu-Villalobos Damasia 
Published: January 2024

Abstract
Growth hormone (GH) modifies liver gene transcription in a sexually dimorphic manner to meet liver metabolic demands related to sex; thus, GH dysregulation leads to sex-biased hepatic disease. We dissected the steps of the GH regulatory cascade modifying GH-dependent genes involved in metabolism, focusing on the male-predominant genes Lcn13, Asns, and Cyp7b1, and the female-predominant genes Hao2, Pgc1a, Hamp2, Cyp2a4, and Cyp2b9. We explored mRNA expression in 2 settings: (i) intact liver GH receptor (GHR) but altered GH and insulin-like growth factor 1 (IGF1) levels (NeuroDrd2KO, HiGH, aHepIGF1kd, and STAT5bCA mouse lines); and (ii) liver loss of GHR, with or without STAT5b reconstitution (aHepGHRkd, and aHepGHRkd + STAT5bCA). Lcn13 was downregulated in males in most models, while Asns and Cyp7b1 were decreased in males by low GH levels or action, or constant GH levels, but unexpectedly upregulated in both sexes by the loss of liver Igf1 or constitutive Stat5b expression. Hao, Cyp2a4, and Cyp2b9 were generally decreased in female mice with low GH levels or action (NeuroDrd2KO and/or aHepGHRkd mice) and increased in HiGH females, while in contrast, Pgc1a was increased in female NeuroDrd2KO but decreased in STAT5bCA and aHepIGF1kd females. Bioinformatic analysis of RNAseq from aHepGHRkd livers stressed the greater impact of GHR loss on wide gene expression in males and highlighted that GH modifies almost completely different gene signatures in each sex. Concordantly, we show that altering different steps of the GH cascade in the liver modified liver expression of Lcn13, Asns, Cyp7b1, Hao2, Hamp2, Pgc1a, Cyp2a4, and Cyp2b9 in a sex- and gene-specific manner.
Predicting Fluid Responsiveness Using Carotid Ultrasound in Mechanically Ventilated Patients: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies
Authors: Lipszyc Adam C. , Walker Samuel C. D. , Beech Alexander P. , Wilding Helen , Akhlaghi Hamed 
Published: January 2024

BACKGROUND:
A noninvasive and accurate method of determining fluid responsiveness in ventilated patients would help to mitigate unnecessary fluid administration. Although carotid ultrasound has been previously studied for this purpose, several studies have recently been published. We performed an updated systematic review and meta-analysis to evaluate the accuracy of carotid ultrasound as a tool to predict fluid responsiveness in ventilated patients.

METHODS:
Studies eligible for review investigated the accuracy of carotid ultrasound parameters in predicting fluid responsiveness in ventilated patients, using sensitivity and specificity as markers of diagnostic accuracy (International Prospective Register of Systematic Reviews [PROSPERO] CRD42022380284). All included studies had to use an independent method of determining cardiac output and exclude spontaneously ventilated patients. Six bibliographic databases and 2 trial registries were searched. Medline, Embase, Emcare, APA PsycInfo, CINAHL, and the Cochrane Library were searched on November 4, 2022. Clinicaltrials.gov and Australian New Zealand Clinical Trials Registry were searched on February 24, 2023. Results were pooled, meta-analysis was conducted where possible, and hierarchical summary receiver operating characteristic models were used to compare carotid ultrasound parameters. Bias and evidence quality were assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool and the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) guidelines.

RESULTS:
Thirteen prospective clinical studies were included (n = 648 patients), representing 677 deliveries of volume expansion, with 378 episodes of fluid responsiveness (58.3%). A meta-analysis of change in carotid Doppler peak velocity (∆CDPV) yielded a sensitivity of 0.79 (95% confidence interval [CI], 0.74–0.84) and a specificity of 0.85 (95% CI, 0.76–0.90). Risk of bias relating to recruitment methodology, the independence of index testing to reference standards and exclusionary clinical criteria were evaluated. Overall quality of evidence was low. Study design heterogeneity, including a lack of clear parameter cutoffs, limited the generalizability of our results.

CONCLUSIONS:
In this meta-analysis, we found that existing literature supports the ability of carotid ultrasound to predict fluid responsiveness in mechanically ventilated adults. ∆CDPV may be an accurate carotid parameter in certain contexts. Further high-quality studies with more homogenous designs are needed to further validate this technology.
Teprotumumab-associated hearing-related adverse events
Authors: Key Amanda , Pederson Addie , Sant Jared , Ray Coby 
Published: January 2024

This study aims to provide a review of the existing literature on teprotumumab (Tepezza)-associated hearing-related adverse effects. A review of PubMed and Embase was conducted using keywords “teprotumumab,” “tepezza,” “hearing disorder[s],” “hearing loss,” and “ototoxicity.” These search results were filtered to include all clinical trials, observational studies, case reports, and case series relevant to the topic of teprotumumab-associated hearing disorders. Data collection from the 15 included studies consisted of: sample size, number and percentage of hearing disorders reported, types of hearing disorders, remission rates, timeline of symptom onset, predisposing risk factors, suggested screening guidelines, and treatment proposals. Teprotumumab-associated hearing disorders are reported in 7-81.5% (median 12%) of clinical study participants. Symptoms described include sensorineural hearing loss (SNHL), hypoacusis, autophony, ear fullness/pressure/plugging, patulous eustachian tube, and tinnitus. Most symptoms improve with discontinuation of teprotumumab, but some symptoms persist after completion of treatment, most commonly SNHL. Symptoms have been reported occurring 3-37 (median 8.4) weeks after treatment initiation, with the majority reported 6 weeks after treatment initiation. Additional prospective studies are needed to clarify how frequently teprotumumab causes ototoxicity. There remains a need for both standardized audiologic screening guidelines and treatment for patients in whom ototoxicity persists post-treatment.

Key Words: teprotumumab, tepezza, hearing disorder[s], hearing loss, ototoxicity
Nieadekwatność doświadczenia a możliwość chaosu w fenomenologii Husserla
Authors: Łaciak Piotr 
Published: January 2024

Zasadnicza teza tekstu brzmi, że możliwość totalnego chaosu empirycznego, która jest rozpatrywana w ramach eksperymentu unicestwienia świata, nie jest możliwością realną, lecz możliwością logiczną. Według Husserla hipoteza totalnego chaosu empirycznego pozostaje w związku z zasadniczą nieadekwatnością doświadczenia świata, która nie wyklucza możliwości nieistnienia świata. Unicestwienie świata jako efekt całkowitego załamania się doświadczenia świata mogę jednak przyjąć tylko hipotetycznie i taka fikcyjna możliwość nie ma charakteru możliwości realnej, ponieważ absolutny fakt mojego doświadczenia poprzedza wszelkie możliwości, nadając im dopiero znaczenie możliwości realnych. Doświadczenie w swej pierwotnej strukturze obejmuje zarówno doświadczenie świata, jak i doświadczenie ego cogito i jest jednym, absolutnym doświadczeniem, tak że możliwość globalnego chaosu empirycznego okazuje się jedynie pustym eksperymentem myślowym i jako taka możliwość ta pozostaje w zasadniczej analogii do możliwości niepoznawalnych rzeczy samych w sobie.
Słowa kluczowe: fenomenologia transcendentalna, eksperyment unicestwienia świata, doświadczenie świata, doświadczenie ego cogito, realna możliwość, logiczna możliwość
Online Advertising, Data Sharing, and Consumer Control
Authors: Johnson Justin P. , Jungbauer Thomas , Preuss Marcel 
Published: January 2024

Invoking a property rights approach, we examine how competition between advertising exchanges influences the targeting options that these exchanges make available to advertisers. When advertisers have strong property rights over data regarding consumers’ active purchase interests, competition between ad exchanges leads to too little sharing of data. This may harm consumers, who receive too few pertinent ads, and advertisers themselves can also be harmed due to a situation resembling a prisoner’s dilemma. We find that reallocating property rights to consumers, that is, giving them the right to opt out of tracking may also benefit consumers who allow tracking by altering the incentives of ad exchanges to offer improved targeting options. In addition, we show that initiatives by Apple and Google to limit third-party tracking and to introduce alternative tracking systems such as Google’s Topics might benefit consumers by weakening the data property rights of advertisers. Because more data are shared by default under such systems, this can be true even if these systems are less accurate than third-party tracking systems. This paper was accepted by Joshua Gans, business strategy.
Why Do Some Conservative CEOs Publicly Support Liberal Causes? Organizational Ideology, Managerial Discretion, and CEO Sociopolitical Activism
Authors: Wowak Adam J. , Busenbark John R. 
Published: January 2024

The phenomenon of chief executive officers (CEOs) speaking out on contested social issues is a recent one, as CEO sociopolitical activism was seen as overly risky, and even taboo, for most of American business history. Yet, CEOs are increasingly choosing sides in societal debates despite the inherent risk of alienating stakeholders who disagree with the CEO’s stance. Even more puzzlingly, conservative CEOs sometimes espouse liberal stances in such debates, which runs counter to the otherwise consistent evidence in the upper echelons literature that CEOs are guided by their own values in their actions. Our study addresses this paradox by examining the antecedents of CEO liberal activism, with an emphasis on the interplay between the CEO’s ideology and the prevailing ideological tilt of the employee population in driving CEOs’ activism decisions. Drawing on the concept of managerial discretion, or latitude of action, we theorize that a pronounced organizational ideology constrains a CEO’s ability to act in accordance with their own values—particularly in the highly symbolic domain of activism. We also argue that conservative CEOs are relatively more focused on instrumental rationales for activism, whereas liberal CEOs tend to prioritize more intrinsic rationales, a consequence of which is that conservative CEOs more heavily weight organizational ideology in their activism decisions. We test our theory in the context of a highly publicized letter signed by nearly 100 CEOs of public companies in opposition to North Carolina’s controversial 2016 “bathroom bill.” Relying on a variety of novel data sources, we find robust support for our theory. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.17160 .
Um estudo sobre os efeitos de sentido na recepção negativa da obra Castanha do Pará pelo viés da Abordagem Crítica da Metáfora
Authors: Sena da Silva Eduarda , Carneiro Cavalcanti Fernanda 
Published: January 2024

Este artigo investiga a reação negativa de um policial, em uma publicação na rede social Facebook, à presença de uma imagem dos quadrinhos Castanha do Pará, de Gidaldi Júnior, em uma exposição de artes, em Belém-PA, no ano de 2018. Para tal, lança-se mão de metodologia de caráter descritivo-interpretativo, em que se analisa a postagem a partir das metáforas conceptuais que estruturam os elementos visuais da imagem. Assim, ao se abordar o valor ideológico da metáfora animal monomodal MENINO É URUBU na imagem, observa-se a emergência de duas metáforas conceptuais: a multimodal AÇÃO DA SEGURANÇA PÚBLICA É GUERRA na postagem, influenciada por sua realidade; e a monomodal SEGURANÇA PÚBLICA É GUERRA CONTRA SUJEITOS EM SITUAÇÃO DE RUA, a qual ele critica por estar presente na História em Quadrinhos e ser inverídica.
Digital scanning in orthodontics: a literature review
Authors: Irving Murray , Nandhra Kieran , Singh Suhavi , Gogna Nikhil 
Published: January 2024

The landscape of orthodontics is changing, and the transition to digital workflows in clinical practice has begun. As new and updated scanner models are regularly being released, it is paramount to assess the current evidence base and compare this to manufacturer claims. At present, there are limited literature reviews assessing and summarizing the clinically relevant features of dental scanners. This review summarizes key findings with respect to accuracy, patient-related outcomes and clinician experiences with digital dental scanners. CPD/Clinical Relevance: Digital scanners are an increasingly popular device in orthodontics, this article provides an up-to-date summary of the pros and cons of scanners in relation to both the patient and orthodontic clinician.
The Influence of Foam Density on the Flexural Properties of Structural Insulated Panels
Authors: Khademibami Laya , Shmulsky Rubin , Senalik Christopher Adam , Seale Roy Daniel , Ross Robert J. , Mohammadabadi Mostafa , Williamson Thomas 
Published: January 2024

Abstract
The effect of foam core density on the strength of structural insulated panels (SIPs) was investigated herein as part of a larger study to determine the creep performance of SIPs. Two depths (16.5 cm and 31.1 cm [6.5 in. and 12.25 in.]) of SIPs were tested in 1/3rd-point flexure according to the American Society of Testing and Materials standard ASTM D6815. Parent SIP panels, each approximately 122 cm (48 in.) wide, were manufactured by a SIPA member in accordance with ESR 4698 and sawn into beam, type elements, each approximately 29.8 cm (11.8 in.) wide, for mechanical testing. All specimens had discontinuities in the foam core in a location that was subject to high shear stress, i.e., between the reaction support and the load head, during the bending tests. The foam density in half of the specimens was approximately 0.016 g/cm3 (1.0 lb/ft3) and in the other half of the specimens, it was approximately 0.019 g/cm3 (1.2 lb/ft3). The flexural properties of these specimens based on the maximum load, Pmax and deflection at failure Δymax (two different depths and two different foam densities) were statistically compared by 2-tailed t test. The results showed that foam density affects the bending performance of SIPs. In both depths, beams with heavier foam cores were stronger for the specific test conditions used in this study. It is noted that results may not be applicable to other design situations such as SIPs subjected to uniform loading with randomly placed foam core joints.
Substitution Estimates for Wood Products in the United States, 1990 to 2020
Authors: Taylor Adam , Hurmekoski Elias , Brandeis Consuelo , Domke Grant 
Published: January 2024

Abstract
Forest carbon stock changes are routinely reported at the national level. Such accounting usually includes carbon sequestered by live trees and stored in living and dead trees, litter, and soil. The carbon stored in harvested wood products (HWPs), while in use and after disposal, may also be reported. However, wood products may provide a further indirect carbon benefit by providing an alternative to materials that require relatively large inputs of fossil-derived carbon. This “substitution impact” of HWPs is not explicitly considered in national reporting for forest carbon accounts because it is not directly comparable with absolute emissions and removals. However, the substitution impact is avoided fossil emissions, which do affect the net climate impact of wood use. Here, we estimate the total substitution impact for wood products harvested recently from forests in the United States. The total substitution impact is based on reported volumes of national wood production and the substitution factors for individual products. The substitution factors are obtained from comparative life-cycle assessments of specific wood products and their nonwood alternatives. The total substitution impact for wood products in the United States in 2020 was 188 TgCO2 equivalents. Calculation of substitution factors is challenged by assumptions about the use of wood products and their alternatives and by limited availability of current and specific life-cycle assessment data; however, our findings indicate that the substitution impact of forest products are a relatively important component of the carbon benefits of wood-based products.
A Specialized Data Crawler for Urban Wood Information
Authors: Thomas R. Edward , Espinoza Omar 
Published: January 2024

Abstract
The Internet is composed of >50 billion Web pages and grows larger every day. As the number of links and specialty subject areas increases, it becomes ever more difficult to find pertinent information. For some subject areas, special purpose data crawlers continually search the Internet for specific information; examples include real estate, air travel, auto sales, and others. The use of such special purpose data crawlers (i.e., targeted crawlers and knowledge databases), also allows the collection and analysis of agricultural and forestry data. Such single-purpose crawlers can search for hundreds of keywords and use machine learning to determine whether or not what is found is relevant. In this paper, we examine the design and data return of such a specialty knowledge database and crawler system developed to find information related to urban wood utilization—products made from timber harvested in cities and municipalities. Our search engine uses intelligent software to locate and update pertinent references related to urban wood as well as to categorize information with respect to common application and interest areas. At the time of this publication, the urban wood knowledge database has cataloged >700 publications regarding various aspects of urban wood.
Characterizing differences in retinal and choroidal microvasculature and structure in individuals with Huntington’s Disease compared to healthy controls: A cross-sectional prospective study
Authors: Joseph Suzanna , Robbins Cason B. , Haystead Alice , Hemesath Angela , Allen Ariana , Kundu Anita , Ma Justin P. , Scott Burton L. , Moore Kathryn P. L. , Agrawal Rupesh , Gunasan Vithiya , Stinnett Sandra S. , Grewal Dilraj S. , Fekrat Sharon 
Published: January 2024

Objective
To characterize retinal and choroidal microvascular and structural changes in patients who are gene positive for mutant huntingtin protein (mHtt) with symptoms of Huntington’s Disease (HD).

Methods
This study is a cross-sectional comparison of patients who are gene positive for mHtt and exhibit symptoms of HD, either motor manifest or prodromal (HD group), and cognitively normal individuals without a family history of HD (control group). HD patients were diagnosed by Duke movement disorder neurologists based on the Unified Huntington’s Disease Rating Scale (UHDRS). Fovea and optic nerve centered OCT and OCTA images were captured using Zeiss Cirrus HD-5000 with AngioPlex. Outcome metrics included central subfield thickness (CST), peripapillary retinal nerve fiber layer (pRNFL) thickness, ganglion cell-inner plexiform layer (GCIPL) thickness, and choroidal vascularity index (CVI) on OCT, and foveal avascular zone (FAZ) area, vessel density (VD), perfusion density (PD), capillary perfusion density (CPD), and capillary flux index (CFI) on OCTA. Generalized estimating equation (GEE) models were used to account for inter-eye correlation.

Results
Forty-four eyes of 23 patients in the HD group and 77 eyes of 39 patients in the control group were analyzed. Average GCIPL thickness and FAZ area were decreased in the HD group compared to controls (p = 0.001, p < 0.001). No other imaging metrics were significantly different between groups.

Conclusions
Patients in the HD group had decreased GCIPL thickness and smaller FAZ area, highlighting the potential use of retinal biomarkers in detecting neurodegenerative changes in HD.