bluuebunny/crossref_metadata_2025_split huggingface dataset:
Книга Притчей Соломоновых в составе Виленского ветхозаветного свода: глоссы и их источники
Authors: Прихотько Кирилл 
Published: January 2025

Данная статья посвящена исследованию записей на полях Книги Притчей Соломоновых в составе Виленского ветхозаветного свода (F 19-262). Подробное изучение глосс в сопоставлении с текстом масоретской Библии, Вульгаты, а также текстов церковнославянской библейской традиции с привлечением лексикографических сборников XVI–XVII вв. позволило определить функции глосс и их возможные источники. Записи на полях служат для исправления допущенных при переписке ошибок прочтения, а также для толкования лексических рутенизмов. Часть глосс предлагают замену для церковнославянизмов. Исследование также показало, что церковнославянская библейская традиция не является источником записей, равно как и текст масоретской Библии. Дважды глоссам нашлись соответствия в азбуковнике и лексиконах, правда более позднего времени, из чего можно предположить, что книжник мог ориентироваться на какие-либо лексикографические сборники его времени.
This article is devoted to the study of the entries in the margins of the Book of the Proverbs of Solomon in the Vilnius copy Old Testament (F 19-262). A detailed study of the glosses in comparison with the text of the Masoretic Bible, the Vulgate, and the texts of the Church Slavonic biblical tradition with the help of lexicographic collections of the 16th–17th centuries allowed us to determine the functions of the glosses and their possible sources. The entries in the margins serve to correct reading errors made during the correspondence, as well as to interpret lexical ruthenisms. Some of the glosses offer substitutions for Church Slavonicisms. The study also showed that the Church Slavonic biblical tradition is not the source of the records, nor is the text of the Masoretic Bible. Twice glosses were found in the alphabet book and lexicons, but of a later time, from which it can be assumed that the scribe could be guided by some lexicographical collections of his time.
Схимонах Иларион (Домрачёв) и его книга «На горах Кавказа»
Authors: Солодов Николай 
Published: January 2025

В статье исследуется история книги схимонаха Илариона (Домрачёва) «На горах Кавказа»: насколько это доступно по имеющимся источникам уточняется биография ее автора; далее устанавливаются этапы эволюции сочинения «На горах Кавказа» и его литературный контекст. Кроме трёх общеизвестных отдельных изданий книги мы привлекаем к анализу предварительный вариант сочинения, распространявшийся в рукописях. В результате существенно корректируются многие распространённые мнения о книге «На горах Кавказа» и её авторе. В частности, выдвигается и обосновывается предположение о том, что старец Дисидерий является авторским персонажем, унаследовавшим биографию о. Илариона и высказывающим его взгляды.
The article examines the history of the book of schemonach Hilarion (Domrachev) «On the Mountains of the Caucasus». His biography is clarified, as far as it is available from available sources; further, the stages of the evolution of the composition «On the Mountains of the Caucasus» and its literary context are established. In addition to the three well-known individual editions of the book, we involve in the analysis a preliminary version of the work, which was distributed in manuscripts. As a result, many common opinions about the book «On the Mountains of the Caucasus» and its author are significantly corrected. In particular, the assumption is put forward and justified that the elder Disiderius is an author’s character who inherited the biography of schemamonk Hilarion and those who express his views.
Личность и общество в мировоззрении протоиерея Василия Зеньковского
Authors: Парпара Анатолий Анатольевич 
Published: January 2025

В статье прослеживается диалектика взаимоотношений личности и общества, согласно прот. Василию Зеньковскому. Используя методы систематизации, сравнения и имманентной критики, автор реконструирует позицию прот. Василия следующим образом. Личность, благодаря христианскому благовестию осознавшая свою свободу, встаёт в оппозицию к Церкви и семье. Это попытка самоутверждения личности приводит к парадоксальным результатам: крайний индивидуализм выражается в имперсонализме и порождает противоположную крайность — коллективизм. Путь к разрешению этих противоречий лежит через достижение органического единства личности с надындивидуальными социальными образованиями, которые прот. Василий рассматривает через призму иерархического персонализма В. Штерна как полноценные самостоятельные сущности. Основа и парадигма нормальных отношений личности и общества — это здоровая семья, в которой создаются оптимальные условия для развития интроцепции и эмпатии. Также огромную роль играют взаимоотношения между личностью и нацией. Интроцепция общественных целей и ценностей приводит к тому, что они становятся органической частью личности и без них личность неизбежно «теряет себя».
The article traces the dialectic of the interrelations between the person and society, according to Archpriest Vasily Zenkovsky. Using methods of systematization, comparison and immanent criticism, the author reconstructs Zenkovsky’s views as follows. Realization of personal freedom caused by the admission of Christianity has put the individual into opposition to the Church and family. This attempt at self-affirmation of the individual leads to paradoxical results: extreme individualism results in impersonalism and also gives rise to its opposite, collectivism. The path to resolving these contradictions lies through achieving the organic unity of the individual with supra-individual social formations. Zenkovsky regards these formations through the prism of W. Stern’s hierarchical personalism as real particular entities. The basis and paradigm of normal relations between the person and society is represented by the normal family, which provides optimal conditions for the development of introception and empathy. The interrelations between the person and the nation also play a huge role. Through introception, social goals and values become an organic part of the person, so that losing these goals and values would inevitably result for a person in «losing their true self».
Общественно-политическое и философское осмысление войны в Новейшей истории
Authors: Суханов Георгий Олегович 
Published: January 2025

Основная цель исследования — хронологический обзор и сравнительный анализ философских взглядов на войну в период Новейшей истории. В работе применяются сравнительно-исторический и герменевтический методы. Для достижения поставленной цели рассматриваются значимые общественно-политические, философские труды, затрагивающие проблему осмысления войны. Первая и Вторая мировые войны — ключевые события современной истории, требующие ясности понимания. Эпоха тотальной войны сменяется обманчивым затишьем второй половины ХХ века: мировое пространство занимают ассиметричные конфликты и гибридные войны. Милитаризм утрачивает позиции: на смену приходит постгероическая эпоха. Интеллектуальное поле занимают вновь востребованная теория справедливой войны и классические оппоненты в лице реалистов и неореалистов. Исследование выявляет преимущества и недостатки восприятия войны различными «нормативными теориями» и определяет их влияние на исторические события Новейшего времени.
The main purpose of the research is a chronological review and comparative analysis of philosophical views on war in the period of Modern history. Comparative historical and hermeneutical methods are used in the work. To achieve this goal, significant socio-political and philosophical works dealing with the problem of understanding the war are considered. The First and Second World Wars are key events in modern history that require clarity of understanding. The era of total war is being replaced by a deceptive lull in the second half of the twentieth century: asymmetric conflicts and hybrid wars occupy the world space. Militarism is losing ground: the post-heroic era is coming to replace it. The intellectual field is occupied by the newly demanded theory of just war and classical opponents in the person of realists and neorealists. The study reveals the advantages and disadvantages of the perception of war by various «normative theories» and determines their impact on the historical events of Modern times.
„Papista” na tronie Zjednoczonego Królestwa? Analiza krytyczna reguły wykluczenia katolików od dziedziczenia brytyjskiej korony
Authors: Krawczyk Michał , Krzywkowska Justyna 
Published: January 2025

Ustawa o sukcesji koronnej (The Succession to the Crown Act) uchwalona przez parlament Zjednoczonego Królestwa w 2013 r. w sposób istotny zmieniła kilkusetletnie zasady rządzące dziedziczeniem brytyjskiego tronu. Utrzymała jednak w mocy istniejącą od końca XVII w. regułę wykluczenia katolików od dziedziczenia tronu. W artykule podjęto polemikę z argumentami wysuwanymi za utrzymaniem takiego wykluczenia. Starano się wykazać, iż zakaz dziedziczenia brytyjskiego tronu przez osobę wyznającą religię katolicką jest nie tylko historycznym anachronizmem sprzecznym z wolnością sumienia i wyznania, ale jest także niepraktyczny, nieracjonalny i rodzący szereg problemów konstytucyjnych.
Comparação entre os Critérios GLIM, o Consenso de Caquexia do Câncer e a ASG-PPP VR para o Diagnóstico Nutricional de Pacientes com Câncer Avançado em Cuidados Paliativos
Authors: Wiegert Emanuelly Varea Maria , Cunha Gabriella da Costa , Calixto-Lima Larissa 
Published: January 2025

Introdução: O diagnóstico nutricional de pacientes com câncer pode variar de acordo com o método utilizado para avaliação. Objetivo: Avaliar a concordância dos critérios do Global Leadership Initiative on Malnutrition (GLIM) e do consenso de caquexia do câncer com avaliação subjetiva global produzida pelo paciente versão reduzida (ASG-PPP VR) para diagnóstico nutricional de pacientes com câncer avançado em cuidados paliativos. Método: Estudo observacional com pacientes com câncer avançado, avaliados no primeiro atendimento em unidade de cuidados paliativos. O estado nutricional foi definido por meio do critério GLIM, do consenso de caquexia e da ASG-PPP VR. Foram analisados os valores de concordância pelo coeficiente de Kappa (k) e calculadas as medidas de acurácia entre os métodos. Resultados: Foram incluídos 254 pacientes, com mediana de idade de 65 anos e predominância do sexo masculino (55,1%). A prevalência de alterações do estado nutricional foi de 71,3%, 79,1% e 58,3%, conforme o GLIM, consenso de caquexia e ASG-PPP VR, respectivamente. A concordância entre o GLIM e o consenso de caquexia foi moderada (k = 0,79; p < 0,001), enquanto com a ASG-PPP VR foi muito fraca (GLIM k = 0,06; p = 0,320 e consenso de caquexia k = 0,06; p = 0,224). A acurácia entre o GLIM e o consenso de caquexia foi alta (92,1%), contudo, demonstraram baixa acurácia (<57,9%) em relação à ASG-PPP VR. Conclusão: Comparados com ASG-PPP VR, os critérios do GLIM e do consenso de caquexia apresentaram concordância e acurácia consideradas não aceitáveis para o diagnóstico nutricional, o que sugere menor aplicabilidade prática para a avaliação nutricional dessa população.
Ferula communis leaf extract: antioxidant capacity, UHPLC–MS/MS analysis, and in vivo and in silico toxicity investigations
Authors: Ed-Dahmani Imad , El Fadili Mohamed , Nouioura Ghizlane , Kandsi Fahd , Atki Yassine El , Abuelizz Hatem A. , Conte Raffaele , Zahra Lafdil Fatima , Taleb Abdeslam , Abdellaoui Abdelfattah , Taleb Mustapha 
Published: January 2025

IntroductionFerula communis has demonstrated an abundance of pharmacological and antioxidative qualities.MethodsThis study investigates the antioxidant activity of F. communis leaf aqueous extract, total polyphenol and flavonoid concentrations, and ultra-high-performance liquid chromatography (UHPLC) composition and then evaluates the toxicity of the plant’s leaves in vitro and in silico. The major compound of the studied extract, namely, p-hydroxybenzoic acid, was chosen for a molecular docking technique to discover the inhibition mechanism toward antioxidant proteins. In addition, a detailed molecular dynamics simulation was carried out to examine the thermodynamic stability of the produced intermolecular interactions. The antioxidant capacity of the extracts of F. communis was evaluated using 2,2-diphenylpicryl hydroxyl (DPPH) radical and ferric reducing antioxidant power (FRAP) procedures. Acute toxicity was tested on albino mice at doses of 200, 300, and 400 mg/kg.ResultsThe results show that the polyphenol and flavonoid contents of the extract are significant (0.257 ± 0.003 mg Eq AG/mg and 0.32 ± 0.04 mg Eq Q/mg, respectively). The antioxidant activity illustrates that the extracts have notable activity in DPPH and FRAP assays. The toxicity study revealed that the mice’s behavior, body weight, and organ weights (liver and kidneys) were unaffected by Ferula communis leaf extract administration compared to controls. UHPLC–tandem mass spectrometry (MS/MS) analysis of the extract highlights the presence of 11 compounds, the most abundant of which is p-hydroxybenzoic acid, representing 53.65%. The predicted pharmacokinetic characteristics of absorption, distribution, metabolism, excretion, and toxicity (ADMET) attest to the well-absorbed nature of the isolated compounds, with human intestinal absorption (HIA) varying from 42% for arbutin (M3) to 100% for ursolic acid (M4).ConclusionIn conclusion, the leaves of Ferula communis are a good source of natural antioxidants and phenolic compounds. Thus, this study demonstrates that this plant has a wide range of applications, including natural food preservatives, pharmaceuticals, and cosmetics, as evidenced by ongoing research.
Epigenome-wide DNA methylation profiling in septic and non-septic patients with similar infections: potential use as sepsis biomarkers
Authors: López-Cruz Ian , García-Giménez José Luis , Madrazo Manuel , García-Guallarte Judit , Piles Laura , Pallardó Federico V. , Artero Arturo 
Published: January 2025

IntroductionSepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ failure. Despite its significant global burden, the underlying mechanisms of immune dysfunction in sepsis remain incompletely understood. This study explores the role of DNA methylation in white blood cells in sepsis pathogenesis.MethodsA prospective case-control study was conducted to compare DNA methylation profiles between patients with community-acquired sepsis and matched controls who had similar infections but did not develop sepsis. Whole blood samples from these patients were analyzed using the Infinium MethylationEPIC v2.0 kit, enabling genome-wide methylation analysis. Selected genes with differential methylation were validated by pyrosequencing.ResultsSignificant differential DNA methylation patterns were identified between septic and non-septic individuals uising. Our results suggest that DNA methylation changes are closely linked to the pathophysiological processes of sepsis, influencing immune cell activation, inflammation, and organ dysfunction. The most prominent findings include the hypomethylation of immune-related genes (SERPINA1, AZU1, MPO, and SLX4), which were strongly correlated with clinical severity and inflammatory markers such as SOFA scores and PCT levels. Correlation analyses demonstrated significant associations between the methylation levels of these genes and clinical severity markers, such as SOFA score and PCT levels. Notably, SLX4 hypomethylation showed the highest predictive value for poor prognosis (AUC 0.821), while SERPINA1 hypomethylation exhibited strong diagnostic potential for sepsis (AUC 0.858).DiscussionOur results underscore the potential of DNA methylation changes, particularly in immune-related genes, to enhance the early detection of sepsis and to stratify patients based on severity. Future research should explore the therapeutic implications of these epigenetic alterations in sepsis care.
Evaluation of the transmission-blocking potential of Plasmodium vivax antigen Pvg37 using transgenic rodent parasites and clinical isolates
Authors: Zhang Di , Zhao Yan , Liu Dongyan , Liu Fei , Liu Pengbo , Zhang Biying , Wu Zifang , Roobsoong Wanlapa , Bantuchai Sirasate , Thongpoon Sataporn , Sripoorote Piyarat , Wang Meilian , Cui Liwang , Cao Yaming 
Published: January 2025

BackgroundPlasmodium vivax is a major cause of malaria, particularly outside Africa, necessitating effective strategies for public health management. Transmission-blocking vaccines (TBVs) have shown the potential to inhibit malaria transmission by targeting antigens expressed in sexual-stage parasites. Pbg37, a conserved protein expressed in sexual stages from gametocyte to ookinete in the rodent parasite P. berghei, is a viable target for TBV development.Methods and findingsIn this study, we constructed a transgenic strain, TrPvg37Pb, expressing Pvg37 using the P. berghei ΔPbg37 strain. Initial findings demonstrated that the replacement of Pbg37 with the exogenous Pvg37 did not impact parasite growth or development. Notably, Pvg37 was expressed during the gametocyte to ookinete development and was associated with the plasmic membrane, similar to Pbg37. To evaluate the potential of Pvg37 as a TBV candidate, we synthesized two Pvg37 polypeptides and immunized rabbits to generate antibodies. In vitro experiments demonstrated that anti-Pvg37-P2 antibodies significantly inhibited the formation of male gametes and ookinetes in the transgenic TrPvg37Pb parasite. Additionally, in mosquito feeding assays, mosquitos feeding on TrPvg37Pb-infected mice passively transferred with anti-Pvg37-P2 antibodies showed a significant 80.2% decrease in oocyst density compared to the control group. Furthermore, in direct membrane feeding experiments using four clinical P. vivax isolates, the anti-Pvg37 antibodies significantly reduced oocyst density by 28.6–50.4%.ConclusionPvg37 is a promising candidate for P. vivax TBV development, deserving further research and optimization to enhance its immunogenicity and transmission-blocking activity.
Amphetamine use as a predictor of cardiovascular and cerebrovascular mortality and morbidity: a longitudinal cohort study of criminal justice clients
Authors: Åhman Ada , Berge Jonas , Håkansson Anders 
Published: January 2025

IntroductionAmphetamine use is an increasing problem, and studies suggest a connection between amphetamine use and cardiovascular and cerebrovascular pathology. However, few long-term studies examine amphetamine users' risk of cardiovascular and cerebrovascular pathology, in comparison to users of other drugs. In addition, in a criminal justice system, illicit drug use and psychiatric comorbidity is common, whereas structured treatment and follow-up is uncommon, and stimulant use is common in this setting. The aim of this study was to investigate the risk of cardiovascular and cerebrovascular morbidity and mortality for intravenous drug users with different drugs as the primary drug, using data from the criminal justice system.MethodsA cohort of injecting substance users (N = 2,422) was identified in the Swedish criminal justice system through interviews with the Addiction Severity Index (ASI) between January 2001 and August 2006. Data on age, sex, self-reported injection drug, tobacco use, and time in prison or custody were retrieved from the ASI database. The clients were followed in national registers up to 2014 with respect to cardiovascular and cerebrovascular morbidity and mortality. Potential predictors of cardiovascular and cerebrovascular events were investigated.ResultSelf-reported main drug was amphetamine in 51.5% (n = 1,247), polysubstance use in 33% (n = 799), and heroin in 15.5% (n = 376) of the cohort. Total observational time for the entire cohort was 23,911 person-years [median 10.3 years (IQR 9.3–11.2 years)]. The highest incidence rates of both cardiovascular and cerebrovascular events were found among amphetamine users. Bivariate analyses showed a significantly higher percentage of cardiovascular events in amphetamine users compared to other substance users (p &lt; 0.044). Amphetamine was not significantly associated with cardiovascular or cerebrovascular events, compared to the main drug heroin or polysubstance use.ConclusionIn this study on substance-using criminal justice clients, while the highest incidence rates of both cardiovascular and cerebrovascular events were found among amphetamine-using individuals, the study did not provide evidence of an independent association. The study highlights the need to take co-factors into account, such as comorbidities and socio-economic factors. More studies are needed to distinguish substance-specific pathology from the impact of other unhealthy lifestyle factors among substance-using individuals.
Quantitative analysis of peripapillary RNFL capillary density and thickness in patients with mild nonproliferative diabetic retinopathy
Authors: Cao Zelie , Tian Tao , Liu Ru , Peng Jinli , Kuang Guoping 
Published: January 2025

PurposeOptical coherence tomography angiography was used to compare the changes of capillary density and thickness of the peripapillary retinal nerve fiber layer in patients with diabetes mellitus (DM) without diabetic retinopathy (DR) and patients with mild nonproliferative diabetic retinopathy (NPDR).MethodsIn this prospective cross-sectional study, 62, 85, and 75 eyes of normal control group (NC), DM group, and NPDR group were included, respectively. All subjects received an optic-disc-centered 6 × 6-mm fundus scan. The annular region outside the optic disc boundary was divided into eight sectors: nasal superior, nasal inferior, inferior nasal (IN), inferior temporal (IT), temporal superior, temporal inferior, superior nasal, and superior temporal (ST). The average retinal nerve fiber layer thickness, average capillary density, and changes in thickness and capillary density of each sector in the annular region were calculated.ResultsCompared with the NC group, the average capillary density of pRNFL in patients with DM and NPDR groups decreased significantly (p &lt; 0.001), and there were significant differences in capillary density in all sectors except the IN sector in the DM group. There was no significant difference in the average thickness of pRNFL between the groups. Only the thickness of ST and IT in DM group and NPDR group, respectively, were significantly lower than that in the control group. In addition, the ROC curve of pRNFL average capillary density has high sensitivity and specificity in distinguishing DR from healthy eyes (AUC = 0.852).ConclusionThe pRNFL average capillary density in diabetic patients without DR and patients with mild NPDR, respectively, were significantly lower than that in healthy controls, especially in the NPDR group.