bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOSIALISASI DAN BIMBINGAN TEKNIS IMPLEMENTASI KURIKULUM MERDEKA SMA DI SMA NEGRI 9 BANDAR LAMPUNG
Authors: Sumiyati  , Kurniawan Rahmat , Sormin Elferida , Simanjuntak Familia Novita , Simatupang Nova Irawati , Purba Leony Sanga Lamsari , Harefa Nelius , Azzahra St Fatimah , Mahendra I Putu 
Published: November 2023

Pengabdian kepada Masyarakat (PkM) oleh Prodi Pendidikan Kimia kolaborasi dengan Institut Teknologi Sumatera, menyasar masyarakat di daerah Bandar Lampung. Masyarakat yang dimaksud dalam hal ini adalah lingkungan Pendidikan secara khusus Sekolah Menengah Atas (SMA) Negeri 9 Bandar Lampung. Adapun kegiatan PkM dengan judul:” Sosialisasi dan Bimbingan Teknis tentang Implementasi Kurikulum Merdeka” akan ditujukan kepada para Guru dan Manajemen Sekolah, sebagai upaya untuk membantu mendorong percepatan pencapaian target sekolah dalam mengimplementasikan kurikulum merdeka belajar. Kegiatan PkM ini dilaksanakan dengan tujuan memberikan kontribusi keilmuan dari sisi ilmu sains dan teknologi dalam membantu SMA N 9 Bandar Lampung menuju sekolah yang mengimplementasikan kurikulum merdeka bahkan sampai kepada pencapaian menjadi sekolah penggerak. Kegiatan dilakukan dalam bentuk sosialisasi dengan menghadirkan para narasumber yang sudah pakar di bidangnya yang juga merupakan dosen Prodi Pendidikan Kimia, yang selanjutnya dirangkai dengan kegiatan workshop penyusunan kurikulum merdeka yang disesuaikan dengan potensi yang dimiliki oleh SMA N 9 Bandar Lampung. Pelaksanaan kegiatan disambut dengan baik, karena materi yang disampaikan sesuai dengan jenis sekolah dengan jalur “Mandiri Berubah”. Sekolah dengan jalur tersebut adalah sekolah dalam hal ini SMA yang baru melaksanakan kurikulum merdeka pada kelas X, dimana masih dalam taraf peralihan dari kurikulum 2013 ke kurikulum merdeka. Materi yang disampaikan mencakup kerangka dasar dan struktur kurikulum SMA , Proyek Peningkatan Profil Pelajar Pancasila (P5) dan Modul Pembelajaran. Kepala Sekolah dan guru SMA Negri 9 Bandarlampung mengusulkan adanya pertemuan tindak lanjut. Hasil kegiatan PkM kolaborasi UKI dan ITERA adalah para guru SMA memperoleh penguatan pemahaman terhadap implementasi kurikulum merdeka yang terdiri dari mendesign, merencanakan, melaksanakan, projek penguatan profil pelajar Pancasila yang dilakukan di dalam kelas, dilingkungan sekolah dan lingkungan masyarakat sekitar lingkungan sekolah, juga bagaimana melaksanakan pencapaian pembelajaran secara akademis yang terdiri dari penyusunan kurikulum organisasi satuan Pendidikan, menjabarkan capaian pembelajaran, menyusun alur tujuan pembelajaran serta menyusun modul pembelajaran.
Kata Kunci:kurikulum merdeka; profil pelajar pancasila; mandiri berubah; modul pembelajaran
Global patent activities survey in the field of welding for the period of 2013−2022
Authors: Bernadska Iryna 
Published: November 2023

This study is an example of the application of IPR methods in the R&D management. The purpose of this article is to describe the global situation and trends ofpatenting in the field of welding. In Ukraine such a study put through for the first time.Based on the results of a series of searches using IPC indexes, an analysis of the worldwide patent statistics in the field of welding for 2013−2022 was accomplished. The overwhelming dominance of China was revealed among the countries in which patent applications are filed. China’s share for 2013-2022 was almost 83 % and continues to grow rapidly. The USA has second rate with 4.3 %, and Japan is third with 3.1 %. Ukraine, having its share as of 0.06 %, ranks 15th among almost 50 countries. The top 10 applicants in the field of welding are manufacturing companies that surpass most countries in the world in terms of their patent activity. Five of them are Japanese, two each from the USA and China, and one is Korean. The R&D sector among the first hundred applicants is mainly represented by Chinese universities. There are only three European companies in the top 100 applicants, namely Siemens, Bosch and Fronius.
Itemized peculiar structure of research and developments in the field of welding was determined and compared with the proper structure of scientific research conducted at the E.O. Paton Electric Welding Institute (PWI). It is typical that in the global dimension, the greatest efforts are focused on patenting universal devices and processes that can be used in various welding methods (44 %), followed by electric arc welding in all its variety of applications (12.2 %) and then laser welding and related technologies (7.5 %). Meanwhile, in the structure of scientific research of PWI, a prominent place is occupied by electric arcwelding technologies (37.0 %), followed by the creation of new substances for the manufacture of rods, electrodes, materials or environments used in welding (15.6 %).On a practical aspect, exploitation of IPR methods in R&D activities is needed not only to determine the freedom to operate of the results of scientific research and newly developed technologies, but for operational and medium-term planning of R&D activities, to determine the place of any scientific institution among other research centers, enterprises and companies which belong to a certain industry.
FAKTOR DAN KENDALA GURU DALAM MENYUSUN KOMPONEN RPP KURIKULUM 2013
Authors: Afridha Sesrita  , Marlina Mina 
Published: November 2023

Penelitian ini berupaya untuk mengetahui beberapa faktor yang mempengaruhi kendala yang dihadapi guru dalam menyusun Rencana Pelaksanaan Pembelajaran (RPP) di SD Negeri Tapos 1. Hasil penelitian mampu memberikan informasi yang penting bagi guru untuk menangani kendala dalam menyusun RPP. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan pendekatan sistematik. Peneliti mengumpulkan data melalui observasi, wawancara dan dokumen dengan salah satu guru SD Negeri Tapos 1. Untuk menganalisis data, peneliti menggunakan model Miles dan Huberman sebagai reduksi data, penyajian dan penarikan kesimpulan. Penelitian ini terdiri dari data primer dan sekunder. Berdasarkan hasil penelitian ini ditemukan bahwa banyak kendala yang dihadapi oleh para guru ketika menyusun bagian-bagian dari RPP antara lain: (1) kendala dalam merumuskan indikator, (2) mencari sumber belajar, (3) mengidentifikasi media pembelajaran, dan (4) menyusun model dan metode, dan (5) membuat penilaian. Banyak faktor yang mempengaruhi kendala guru, antara lain: (1) guru tidak memahami prinsip menyusun beberapa bagian RPP Kurikulum 2013, (2) waktu yang singkat untuk menyusun RPP, (3) ketidakjelasan pelatihan yang diberikan kepada guru dan (4) rendahnya motivasi guru.
Case Report: Hypertrophic cardiomyopathy with recurrent episodes of ventricular fibrillation and concurrent sinus arrest
Authors: Hamidi Jassin , Winter Joachim , Weber Rene , Dittmann Sven , Schulze-Bahr Eric 
Published: November 2023

BackgroundHypertrophic cardiomyopathy (HCM) is a serious hereditary cardiomyopathy. It is characterized morphologically by an increased left ventricular wall thickness and mass and functionally by enhanced global chamber function and myocellular contractility, diastolic dysfunction, and myocardial fibrosis development. Typically, patients with HCM experience atrial fibrillation (AF), syncope, and ventricular fibrillation (VF), causing severe symptoms and cardiac arrest. In contrast, sinoatrial node (SAN) arrest in the setting of HCM is uncommon. In particular, during VF, it has not been described so far.Case summaryIn this study, we report an 18-year-old woman patient with sudden cardiac arrest due to VF and successful cardiopulmonary resuscitation as the first clinical manifestation of non-obstructive HCM. Subsequently, a subcutaneous implantable cardioverter-defibrillator (ICD) was implanted for secondary VF prophylaxis. However, additional episodes of VF occurred. During these, device interrogation revealed a combined occurrence of VF, bradycardia, and SAN arrest, requiring a device exchange into a dual-chamber ICD. A heterozygous, pathogenic variant of the MYH7 gene (c.2155C&gt;T; p.Arg719Trp) was identified as causative for HCM.DiscussionFirst published in 1994, the particular MYH7 variant (p.Arg719Trp) was described in HCM patients with a high incidence of premature cardiac death and a reduced life expectancy. Electrophysiological studies on HCM patients are mainly performed to treat AF and ventricular tachycardia. Further extraordinary arrhythmic phenotypes were reported only in a few HCM patients. Taken together, the present case with documented co-existing VF and SAN arrest is rare and also emphasizes addressing the presence of SAN arrest (in particular, during VF episodes) in HCM patients when a distinct ICD device is considered for implantation.
Utility of coronary artery calcium in refining 10-year ASCVD risk prediction using a Thai CV risk score
Authors: Tiansuwan Noppanat , Sasiprapha Thinnakrit , Jongjirasiri Sutipong , Unwanatham Nattawut , Thakkinstian Ammarin , Laothamatas Jiraporn , Limpijankit Thosaphol 
Published: November 2023

BackgroundCoronary artery calcium (CAC) scanning is a valuable additional tool for calculating the risk of cardiovascular (CV) events. We aimed to determine if a CAC score could improve performance of a Thai CV risk score in prediction of 10-year atherosclerotic cardiovascular disease (ASCVD) risk for asymptomatic patients with CV risk factors.MethodsThis was a retrospective cohort study that enrolled asymptomatic patients with CV risk factors who underwent CAC scans between 2005 and 2013. The patients were classified as low-, intermediate-, or high-risk (&lt;10%, 10%–&lt;20%, and ≥20%, respectively) of having ASCVD within 10-years based on a Thai CV risk score. In each patient, CAC score was considered as a categorical variable (0, 1–99, and ≥100) and natural-log variable to assess the risk of developing CV events (CV death, non-fatal MI, or non-fatal stroke). The C statistic and the net reclassification improvement (NRI) index were applied to assess whether CAC improved ASCVD risk prediction.ResultsA total of 6,964 patients were analyzed (mean age: 59.0 ± 8.4 years; 63.3% women). The majority of patients were classified as low- or intermediate-risk (75.3% and 20.5%, respectively), whereas only 4.2% were classified as high-risk. Nearly half (49.7%) of patients had a CAC score of zero (no calcifications detected), while 32.0% had scores of 1–99, and 18.3% of ≥100. In the low- and intermediate-risk groups, patients with a CAC ≥100 experienced higher rates of CV events, with hazard ratios (95% CI) of 1.95 (1.35, 2.81) and 3.04 (2.26, 4.10), respectively. Incorporation of ln(CAC + 1) into their Thai CV risk scores improved the C statistic from 0.703 (0.68, 0.72) to 0.716 (0.69, 0.74), and resulted in an NRI index of 0.06 (0.02, 0.10). To enhance the performance of the Thai CV risk score, a revision of the CV risk model was performed, incorporating ln(CAC + 1), which further increased the C statistic to 0.771 (0.755, 0.788).ConclusionThe addition of CAC to traditional risk factors improved CV risk stratification and ASCVD prediction. Whether this adjustment leads to a reduction in CV events and is cost-effective will require further assessment.
Study on the vertical well seepage model in composite carbonate reservoirs
Authors: Minjing Chen , Zhan Qu , Jiajun Cao , Junhang Hu , Xinggang Meng , Shuaihu Jia , Chenyu Zhang 
Published: November 2023

Introduction: Carbonate reservoirs are widely distributed throughout the world. Due to the good physical properties of the reservoirs, they are easily contaminated by mud during drilling opening, so they are often put into production after acidification. After acidification, the near-well reservoir’s physical property is improved, while the far-well reservoir’s physical property remains unchanged. Such reservoirs are commonly called composite reservoirs. Composite carbonate reservoir seepage law is more complicated.Methods: In this paper, the point source function of a triple-medium composite reservoir is established using the source function theory, Laplace transform, perturbation transform, and linear superposition principle of partial differential equation.Results: Second, the vertical well seepage model of a composite reservoir is obtained through the new point source function.Discussion: Finally, the correctness of the model is verified, and the sensitivity analysis of the key parameters affecting the seepage law is carried out. The applicability of the model established in this paper is demonstrated by two wells in the field. This paper provides a theoretical basis for vertical well test analysis of composite reservoirs.
miR-135a-5p overexpression in peripheral blood-derived exosomes mediates vascular injury in type 2 diabetes patients
Authors: Xie Kangling , Li Cui , Wang Mingzhu , Fu Siqian , Cai Ying 
Published: November 2023

ObjectiveDiabetes pathology relies on exosomes (Exos). This study investigated how peripheral blood Exo-containing microRNAs (miRNAs) cause vascular injury in type 2 diabetes (T2D).MethodsWe removed DEmiRNA from T2D chip data from the GEO database. We isolated Exo from 15 peripheral blood samples from T2D patients and 15 healthy controls and measured Exo DEmiRNA levels. We employed the intersection of Geneards and mirWALK database queries to find T2D peripheral blood mRNA-related chip target genes. Next, we created a STRING database candidate target gene interaction network map. Next, we performed GO and KEGG enrichment analysis on T2D-related potential target genes using the ClusterProfiler R package. Finally, we selected T2D vascular damage core genes and signaling pathways using GSEA and PPI analysis. Finally, we used HEK293 cells for luciferase assays, co-cultured T2D peripheral blood-derived Exo with HVSMC, and detected HVSMC movement alterations.ResultsWe found 12 T2D-related DEmiRNAs in GEO. T2D patient-derived peripheral blood Exo exhibited significantly up-regulated miR-135a-3p by qRT-PCR. Next, we projected miR-135a-3p’s downstream target mRNA and screened 715 DEmRNAs to create a regulatory network diagram. DEmRNAs regulated biological enzyme activity and vascular endothelial cells according to GO function and KEGG pathway analysis. ErbB signaling pathway differences stood out. PPI network study demonstrated that DEmRNA ATM genes regulate the ErbB signaling pathway. The luciferase experiment validated miR-135a-3p and ATM target-binding. Co-culture of T2D patient-derived peripheral blood Exo with HVSMC cells increases HVSMC migration, ErbB2, Bcl-2, and VEGF production, and decreases BAX and ATM. However, miR-135a-3p can reverse the production of the aforesaid functional proteins and impair HVSMC cell movement.ConclusionT2D patient-derived peripheral blood Exo carrying miR-135a-3p enter HVSMC, possibly targeting and inhibiting ATM, activating the ErbB signaling pathway, promoting abnormal HVSMC proliferation and migration, and aggravating vascular damage.
Case Report: A novel de novo variant of COL1A1 in fetal genetic osteogenesis imperfecta
Authors: Mai Qiuyan , Han Ruining , Chen Yinlong , Shen Ke , Wang Shimin , Zheng Qingliang 
Published: November 2023

ObjectiveOsteogenesis imperfecta (OI) is a rare genetic disorder. Clinical severity is heterogeneous. The purpose of this study was to investigate the genetic characteristics of a fetus with OI by whole exome sequencing (WES) and identify the cause of the disease.MethodsIn this study, a fetus with osteogenic dysplasia was referred to our hospital. DNA was extracted from the aborted fetal tissue and peripheral blood of the parents. To identify the pathogenic genes, we conducted the trio-WES using DNA. A de novo variant in the COL1A1 gene is suspected to be the cause of the OI phenotype. We used Sanger sequencing for validation and various bioinformatics methods (such as SIFT, PolyPhen2, Mutation Taster, conservative analysis, SWISS Model, glycosylation site prediction, and I-Mutant 2.0) for analysis.ResultsBoth WES and Sanger sequencing identified a novel de novo variant of COL1A1 (c. 1309G&gt;A, p. Gly437Ser) in a fetus with OI. Bioinformatic analysis showed that the affected residue, p. Gly437, was highly conserved in multiple species and predicted that the variant was deleterious and may have an impact on protein function. This variant is present in highly conserved glycine residues of Gly-X-Y sequence repeats of the triple helical region of the collagen type I α chain, which may be the cause of OI.ConclusionThis study revealed that the c.1309G&gt;A (p. Gly437Ser) variant in the COL1A1 gene may be the genetic cause of fetal OI in this case. The discovery of this variant enriched the variation spectrum of OI. WES improves the accurate diagnosis of fetal OI, and doctors can provide patients with appropriate genetic counseling.
Assessing the efficiency of microplastics extraction methods for tropical beach sediments and matrix preparation for experimental controls
Authors: Bonita Jan Danielle P. , Gomez Norchel Corcia F. , Onda Deo Florence L. 
Published: November 2023

IntroductionMicroplastic pollution has become a global issue, eliciting attention not just from the scientific community but also both from the public and governmental bodies. Drawing data-driven policies and interventions, however, remain difficult due to the severely lacking baseline information from different environments such as beaches. One of the challenges in doing baseline studies is the lack of harmonized methodologies that will allow for comparison of results, integration of data, and its effective translation to evidence-based policies. Emphasis on quality control measures among baselining efforts through the proper implementation of experimental controls is also lacking.MethodologyTo address these gaps, we compared methodologies for preparing the sediment matrix for experimental controls, as well as evaluated protocols for extracting microplastics from tropical beach sediments. Beach sediments were collected, dried, sieved, and spiked with known amounts of microplastics of different polymer types. The removal and extraction efficiencies of the protocols being compared were evaluated.Results and discussionOur results showed that subjecting beach sediments to a furnace at 550° C for 4 hours is the most efficient way to remove plastic contamination, implying its applicability for preparing experimental controls. Meanwhile, a modified version of Masura et al. (2015), one of the widely cited methodologies for microplastics extraction, exhibited the highest mean extraction efficiency (99.05 ± 0.82%) among the protocols being compared. Results of this work will be useful in identifying methods that can be adopted and utilized for research and baselining efforts not just in the Philippines but also in Southeast Asia. This will also be helpful in the harmonization of methods, data reporting, and even skills as implemented through the regional and national action plans to address marine plastic pollution.
Changes in axial length in anisometropic children wearing orthokeratology lenses
Authors: Qin Jian , Qing Huiling , Ji Na , Lyu Tianbin , Ma Hui , Shi Menghai , Yu Shiao , Ma Conghui , Fu Aicun 
Published: November 2023

PurposeThere is a particular anisometropia occurring in one eye with myopia, while the other eye has very low myopia, emmetropia, or very low hyperopia. It is unclear how the binocular axial length changes when these children wear unilateral OK lenses only in the more myopic eyes. This study investigates the changes in the axial elongation of both eyes.MethodsThis is a 1-year retrospective study. In total, 148 children with myopic anisometropia were included. The more myopic eyes were wearing orthokeratology lenses (treated eyes), whereas the contralateral eyes were not indicated for visual correction (untreated eyes). The untreated eyes were classified into three subgroups based on the spherical equivalent refraction (SER): low myopia (≤ -0.50 D, n = 37), emmetropia (+0.49 to −0.49 D, n = 76), and low hyperopia (≥0.50 D, n = 35). Changes in the axial length (AL) were compared between the untreated and treated eyes and among the three subgroups.ResultsThe axial elongation was 0.14 ± 0.18 mm and 0.39 ± 0.27 mm in all treated and untreated eyes, respectively (p &lt; 0.001). The interocular AL difference decreased significantly from 1.09 ± 0.45 mm at the baseline to 0.84 ± 0.52 mm at 1 year (p &lt; 0.001). The baseline median (Q1, Q3) SER of the untreated eyes were −0.75 D (−0.56, −0.88 D), 0.00 D (0.00, −0.25 D), and +0.75 D (+1.00, +0.62 D) in low myopia, emmetropia, and low hyperopia subgroups, respectively. The axial elongation was 0.14 ± 0.18 mm, 0.15 ± 0.17 mm, and 0.13 ± 0.21 mm (p = 0.92) in the treated eyes and 0.44 ± 0.25 mm, 0.35 ± 0.24 mm, and 0.41 ± 0.33 mm in the untreated eyes (p = 0.11) after 1 year. Multivariate linear regression analyses only showed significant differences in axial elongation between the emmetropia and low myopia subgroups of untreated eyes (p = 0.04; p &gt; 0.05 between other subgroups).ConclusionUnilateral orthokeratology lenses effectively reduced axial elongation in the more myopic eyes and reduced interocular AL differences in children with myopic anisometropia. The refractive state of the untreated eyes did not affect the axial elongation of the more myopic eye wearing the orthokeratology lens. In the untreated eyes, AL increased faster in the low myopia subgroup than in the emmetropia subgroup.
Ideal serum non-ceruloplasmin bound copper prediction for long-term treated patients with Wilson disease: a nomogram model
Authors: Tao Zhuang , Yang Pingping , Zhou Jiafeng , Wang Rui , Jiang Zhenzhen , Han Hui , Wang Meixia 
Published: November 2023

PurposeThis study aimed to explore the factors associated with the optimal serum non-ceruloplasmin bound copper (NCBC) level and develop a flexible predictive model to guide lifelong therapy in Wilson disease (WD) and delay disease progression.MethodsWe retrospectively collected clinical data from 144 patients hospitalized in the Encephalopathy Center of the first affiliated hospital of Anhui University of Chinese Medicine between May 2012 and April 2023. Independent variables were selected using variate COX and LASSO regressions, followed by multivariate COX regression analysis. A predictive nomogram was constructed and validated using the concordance index (C-index), calibration curves, and clinical decision curve analysis, of which nomogram pictures were utilized for model visualization.ResultsA total of 61 (42.36%) patients were included, with an average treatment duration of 55.0 (range, 28.0, 97.0) months. Multivariate regression analysis identified several independent risk factors for serum NCBC level, including age of diagnosis, clinical classification, laminin liver stiffness measurement, and copper to zinc ratio in 24-h urinary excretion. The C-index indicated moderate discriminative ability (48 months: 0.829, 60 months: 0.811, and 72 months: 0.819). The calibration curves showed good consistency and calibration; clinical decision curve analysis demonstrated clinically beneficial threshold probabilities at different time intervals.ConclusionThe predictive nomogram model can predict serum NCBC level; consequently, we recommend its use in clinical practice to delay disease progression and improve the clinical prognosis of WD.