bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical study of alisol B 23‐acetate on methionine and choline deficient diet‐induced nonalcoholic steatohepatitis based on untargeted metabolomics
Authors: Li Hua‐jun , Wang Yuan‐song , Wang Ya‐nan , Liu Ai‐ru , Su Xiu‐hai , Ma Zi‐ang , Wang Li‐xin , Zhang Zhong‐yong , Lv Shu‐quan , Miao Jing , Cui Huan‐tian 
Published: October 2023

AbstractAlisol B 23‐acetate (AB23A) has been demonstrated to have beneficial effects on nonalcoholic steatohepatitis (NASH). However, the mechanisms of AB23A on NASH remain unclear. This study aimed to investigate the mechanisms underlying the metabolic regulatory effects of AB23A on NASH. We used AB23A to treat mice with NASH, which was induced by a methionine and choline deficient (MCD) diet. We initially investigated therapeutic effect and resistance to oxidation and inflammation of AB23A on NASH. Subsequently, we performed untargeted metabolomic analyses and relative validation assessments to evaluate the metabolic regulatory effects of AB23A. AB23A reduced lipid accumulation, ameliorated oxidative stress and decreased pro‐inflammatory cytokines in the liver. Untargeted metabolomic analysis found that AB23A altered the metabolites of liver. A total of 55 differential metabolites and three common changed pathways were screened among the control, model and AB23A treatment groups. Further tests validated the effects of AB23A on modulating common changed pathway‐involved factors. AB23A treatment can ameliorate NASH by inhibiting oxidative stress and inflammation. The mechanism of AB23A on NASH may be related to the regulation of alanine, aspartate and glutamate metabolism, d‐glutamine and d‐glutamate metabolism, and arginine biosynthesis pathways.
Human platelet‐derived growth factor‐BB (rhPDGF‐BB) with collagen matrix for sinus elevation without using a bone graft
Authors: Ghassib Iya H. , Saleh Muhammad H. A. , Wang Hom‐Lay 
Published: October 2023

AbstractBackgroundThis case report involves a 38‐year‐old male who presented to the clinic after experiencing complications from a tooth extraction, including a dislodged root segment in the sinus, a sinus wall fenestration on the palate, a residual bone height (RBH) of 3 mm, and inadequate healing of the soft tissue. He presented for implant placement.MethodsRecombinant human platelet‐derived growth factor‐BB (rh‐PDGF‐BB) was applied to a wound dressing material and placed in the sinus cavity alongside a 4.8 × 10 mm dental implant (Straumann SP, Straumann, Andover, MA, USA.). As documented in the literature, a graftless sinus lift via a lateral window was performed using a split‐thickness flap technique to elevate the sinus membrane, re‐establish its integrity, and restore its barrier function.ResultsAn 8‐month cone beam computed tomography assessment showed a 6.2 mm vertical bone gain and complete implant coverage.ConclusionThis approach provided a successful alternative to shorten treatment duration and achieve favorable radiographic outcomes during early healing.Key pointsThe use of rhPDGF‐BB and a collagen matrix in a sinus lift procedure emerges as a practical therapeutic option when grafting might lack predictability and notably consume more treatment time, while also achieving the desired bone height when used with a simultaneously placed implant.
A Comparative Analysis of Phytochemicals, Metal Ions, Volatile Metabolites in Heart Wood, Stem Bark and Leaves of Salix alba L. along with in Vitro Antioxidant, Antacid, Antimicrobial Activities for Sake of Environment Conservation by Substitution of Stem Bark With Leaf
Authors: Gandhi Yashika , Rawat Hemant , Singh Dhanjal Daljeet , Kumar Vijay , Charde Vaibhav , Soni Hemant , Mishra Sujeet K. , Singh Gagandeep , Singh Simranjeet , Sharma Preeti , Shakya Santosh K. , Narsimhaji C. V. , Meena Ajay K , Singh Arjun , Singh Ravindra , Srikanth Naryanam , Acharya Rabinarayan 
Published: October 2023

AbstractThe genus of Salix is used in food, medicine and nutraceuticals, and standardized by using the single marker compound Salicin only. Stem bark is the official part used for the preparation of various drugs, nutraceuticals and food products, which may lead to overexploitation and damage of tree. There is need to search substitution of the stem bark with leaf of Salix alba L. (SA), which is yet not reported. Comparative phytochemicals viz. Salicin, Procyanidin B1 and Catechin were quantified in the various parts of SA viz. heart wood (SA‐HW), stem bark (SA‐SB) and leaves (SA‐L) of Salix alba L.by using newly developed HPLC method. It was observed that SA‐HW and SA‐L contained far better amount of Salicin, Procyanidin B and Catechin as compared to SA‐SB (SA‐HW~SA‐L≫SA‐SB). Essential and toxic metal ions of all three parts were analysed using newly developed ICP‐OES method, where SA‐L were founded as a rich source of micronutrients and essential metal ions as compared to SA‐SB and SA‐HW. GC‐MS analysis has shown the presence of fatty acids and volatile compounds. The observed TPC and TFC values for all three parts were ranged from 2.69 to 32.30 mg GAE/g of wt. and 37.57 to 220.76 mg QCE/g of wt. respectively. In DPPH assay the IC50 values of SA‐SB, SA‐HW, and SA‐L were 1.09 (±0.02), 5.42 (±0.08), and 8.82 (±0.10) mg/mL, respectively. The order of antibacterial activities against E. coli, S. aureus, P. aeruginosa, and B. subtilis strains was SA‐L>SA‐HW>SA‐SB with strong antibacterial activities against S. aureus, and B. subtilis strains. The antacid activities order was SA‐L>SA‐SB>SA‐HW. The leaves of SA have shown significant source of nutrients, phytochemicals and medicinal properties than SA‐HW and SA‐SB. The leaves of SA may be considered as substitute of stem bark to save the environment or to avoid over exploitation, but after the complete pharmacological and toxicological studies.
Single center experience with the balloon‐expandable Myval transcatheter aortic valve system with the first 100 patients: 30‐day and 1‐year follow‐up
Authors: Magyari Balázs , Kittka Bálint , Goják Ilona , Kasza Gábor , Schönfeld Kristóf , Szapáry László Botond , Simon Mihály , Kiss Rudolf , Bertalan Andrea , Várady Edit , Gyimesi András , Szokodi István , Horváth Iván 
Published: October 2023

AbstractAimsTo report our single‐center data, regarding the first 100 patients who underwent TAVR procedure with the new balloon‐expandable MYVAL system. We report 30‐day and 1‐year outcomes in low to high‐risk TAVR patient population.MethodsFrom November 2019 to July 2021, 100 consecutive patients underwent TAVR procedure. Patient outcome was classified according to the VARC‐2 definitions. The device performance was assessed using transthoracic echocardiography. Data collection was allowed by the Local Ethical Committee.ResultsThe mean age was 74.7 years, 63 (63%) were male. The mean Euroscore II and STS score were 4.8 ± 4.9 and 5.6 ± 3.9, respectively. Transfemoral access was the most frequent (surgical vs. percutaneous 2% vs. 97%) and in one patient surgical subclavian access was used. VARC‐2 outcomes were as follows: device success 99%, STROKE 1%, major and minor vascular complication was 1% and 11%, respectively, the rate of new permanent pacemaker implantation was 30.7%. At discharge, the incidence of grade I, grade II aortic regurgitation was 39% and 1%, respectively, without relevant PVL. In‐hospital mortality was only 1%. These results included a high proportion (17%) of patients with bicuspid aortic valves. At 1 year, the all‐cause mortality rate was 7% (only two due to cardiac event) and only a single patient had valve‐related dysfunction requiring surgical aortic replacement.ConclusionsTAVR procedure with MYVAL transcatheter heart valve system shows excellent 30‐day and 1‐year outcomes regarding patient survival, technical success, and valve‐related adverse events. The limitations of our study comprise a single‐center study with retrospective data collection.
Delayed rupture of peroneal artery pseudoaneurysm following endovascular treatment in a patient with chronic limb‐threatening ischemia: A case report
Authors: Asano Kazuhiro , Kojima Shunsuke , Obunai Kotaro , Nakama Tatsuya 
Published: October 2023

AbstractBelow‐the‐knee (BTK) pseudoaneurysms that occur after endovascular therapy (EVT) and result in delayed rupture have rarely been reported. In this report, we present a rare case of an 86‐year‐old man with chronic limb‐threatening ischemia who developed delayed rupture of an idiopathic pseudoaneurysm of the peroneal artery (PA) following EVT. The PA chronic total occlusion (CTO) was successfully crossed using a guidewire via an antegrade approach, however, subintimal crossing was confirmed by intravascular ultrasound. Balloon angioplasty was then performed using an appropriately sized balloon, resulting in successful recanalization of the PA CTO with minor dissection and no complications. Postoperatively, the patient's condition was stable until he suddenly complained of right calf pain 10 days after EVT. Computed tomography revealed a rupture of the PA pseudoaneurysm. Urgent angiography revealed two pseudoaneurysms, one saccular and the other spindle‐shaped. The ruptured saccular aneurysm was successfully excluded through coil embolization and stent graft placement. To the best of our knowledge, this is the first reported case of delayed rupture of a BTK pseudoaneurysm following EVT. Balloon angioplasty in the subintimal space can lead to the formation of a pseudoaneurysm and its delayed rupture.
Herpes zoster occurring over the site of tinea cruris—A case report based on the model of T‐cell exhaustion in the Ruocco's immunocompromised cutaneous district
Authors: Mathur Mahesh , Thakur Neha , Jaiswal Sunil , Maharjan Srijana , Paudel Supriya , Shrestha Anjali 
Published: October 2023

Key Clinical MessageImmunocompromised district refers to the area of the skin with altered immune response predisposing secondary diseases to develop in an immunocompetent individual. This might be explained by the theory of T‐cell exhaustion which is characterized by the impairment of the effector function of antigen‐specific T cells due to chronic persistence of the primary antigen. T‐cell exhaustion model is not well known; however, it serves as a newer concept in the pathogenesis of diseases occurring simultaneously over the same site. Thus, it is not surprising to have two different infectious or non‐infectious dermatoses over the same site one preceding the other as observed in our patient. The concept of immunocompromised district and T‐cell exhaustion is a rare phenomenon; however, it should be identified by the treating physicians/dermatologists for the optimum management of the atypical presentation of the diseases.
A case report of clubbing as the initial sign of systemic sclerosis sine scleroderma: A rare possible presentation
Authors: Amirpour Anahita , Ghorbani Parastoo , Ghadirzadeh Erfan , Charkazi Elham , Paraandavaji Elham 
Published: October 2023

Key Clinical MessageEven in the absence of characteristic cutaneous symptoms of scleroderma, systemic sclerosis should be considered in the differential diagnosis of patients initially diagnosed with idiopathic interstitial lung disease.AbstractSystemic sclerosis (SSc) is an idiopathic connective tissue disorder characterized by multisystem involvement. Although skin thickening is a hallmark manifestation of SSc, a subset known as systemic sclerosis sine scleroderma (ssSSc) presents with internal organ involvement and positive serologic markers in the absence of significant cutaneous manifestations. We report the case of a 36‐year‐old Iranian woman who presented with clubbing as an initial symptom of ssSSc. Notably, clubbing as the sole initial sign of the disease has not been previously reported. Timely diagnosis of ssSSc is crucial to facilitate appropriate treatment and prevent disease progression. Physicians should adopt a comprehensive approach when evaluating patients presenting with limited clinical features, as they might be indicative of underlying ssSSc.
Agenesis of the right lung in an adult woman: A case report
Authors: Gonçalves Elias , Sachicola Ofélia , Estanislau Bartolomeu , Quifica Francisca , Morais Humberto , Arrais Margarete 
Published: October 2023

Key Clinical MessagePulmonary agenesis is a rare congenital abnormality. Patients with hemithorax white‐out on x‐rays should be treated with caution, especially in resource‐limited countries where chest CT and bronchofibroscopy are not available to confirm the diagnosis.AbstractPulmonary agenesis is an uncommon congenital abnormality defined by the complete absence of the lung parenchyma, as well as the bronchial and vascular structures. Right‐sided pulmonary agenesis is less frequent, has a worse prognosis, and is usually associated with other congenital abnormalities. We reported the clinical case of a 31‐year‐old woman with right pulmonary agenesis, and no other congenital abnormalities, whose diagnosis was confirmed by thoracic computed tomography and bronchofibroscopy and who has a good prognosis.
Cr2O3 Promoted In2O3 Catalysts for CO2 Hydrogenation to Methanol
Authors: Yang Yuying , Guo Meng , Zhao Fuzhen 
Published: October 2023

AbstractCr2O3 was applied to study the modification of In2O3 based catalysts for CO2 hydrogenation to methanol reaction. Combined with X‐ray diffraction (XRD), scanning transmission electron microscopy (STEM), X‐ray photoelectron spectroscopy (XPS), etc., the structure of the catalysts was characterized. The reaction performances for CO2 hydrogenation to methanol were evaluated on a stainless‐steel fix‐bed reactor. The results showed that solid solutions were formed for the Cr2O3 promoted In2O3 catalysts. The important role of electronic interaction between Cr2O3 and In2O3 was revealed in the hydrogenation reaction. In1.25Cr0.75O3 sample exhibited the highest methanol yield, which was 2.8 times higher than that of pure In2O3. No deactivation was observed for In1.25Cr0.75O3 sample during the 50 hours of reaction. The improved catalytic performance may be due to the formation of the solid solutions and the highest amount of oxygen vacancies.
Organic Semiconductor Based on N, S‐Containing Crown Ether Enabling Efficient and Stable Perovskite Solar Cells
Authors: Chen Kaixing , Zeng Ye , Gao Xing , Liu Xiaorui , Zhu Linna , Wu Fei 
Published: October 2023

AbstractThe uncoordinated lead cations are ubiquitous in perovskite films and severely affect the efficiency and stability of perovskite solar cells (PSCs). In this work, 15‐crown‐5 with various heteroatoms are connected to the organic semiconductor carbazole diphenylamine, and two new compounds, CDT‐S and CDT‐N, are developed to modify the Pb2+ defects in perovskite films through the anti‐solvent method. Apart from the oxygen atoms, there are also N atoms on crown ether ring in CDT‐N, and both S and N heteroatoms in CDT‐S. The heteroatoms enhance the interaction between the crown ether‐based semiconductors and the undercoordinated Pb2+ defect in perovskite. Particularly, the stronger interaction between S atoms and Pb2+ further enhances the defect passivation effect of CDT‐S than CDT‐N, thereby more effectively suppressing the non‐radiative recombination of charge carriers. Finally, the efficiency of the device treated with CDT‐S is up to 23.05 %. Moreover, the unencapsulated device based on CDT‐S maintained 90.5 % of the initial efficiency after being stored under dark conditions for 1000 hours, demonstrating good long‐term stability. Our work demonstrates that crown ethers are promising in perovskite solar cells, and the crown ether containing multiple heteroatoms could effectively improve both efficiency and stability of devices.
Applying software‐defined ambient intelligence techniques for cognitive and emotional awareness in the Internet of Things
Authors: Azeez Syed Salman , Nag Ishita , Basu Shreya , Kumar Sharma Deepak 
Published: October 2023

SummarySmart “discrete” technologies are taking over everyday activities with an intended shift towards complete automation. With this, ambient intelligence (AmI) has come under the limelight, to make these routines subtle and automated, enabled through the widespread adoption of the ubiquitous and pervasive Internet of Things (IoT). AmI is context‐driven depending largely on user input through various interfaces, which is nothing but the interplay between IoT and artificial intelligence (AI). Despite extensive incorporation of personal digital assistants and smart home systems, AI is not yet capable of accurately interpreting and responding to human emotions. This paper aims to present one such application to gauge the emotional and cognitive state of the user and respond appropriately, be it ambient lighting or an emergency SOS. The proposed model extracts network packets to work with audio messages on the real‐time transport protocol (RTP) layer and presents a lightweight multilayer perceptron (MLP)‐based speech emotion recognition (SER) model for emotional analysis with an accuracy of 80.52%. It also features a simple confidence rating system for further optimization.
The nature of science: The fundamental role of natural history in ecology, evolution, conservation, and education
Authors: Nanglu Karma , de Carle Danielle , Cullen Thomas M. , Anderson Erika B. , Arif Suchinta , Castañeda Rowshyra A. , Chang Lucy M. , Iwama Rafael Eiji , Fellin Erica , Manglicmot Regine Claire , Massey Melanie D. , Astudillo‐Clavijo Viviana 
Published: October 2023

AbstractThere is a contemporary trend in many major research institutions to de‐emphasize the importance of natural history education in favor of theoretical, laboratory, or simulation‐based research programs. This may take the form of removing biodiversity and field courses from the curriculum and the sometimes subtle maligning of natural history research as a “lesser” branch of science. Additional threats include massive funding cuts to natural history museums and the maintenance of their collections, the extirpation of taxonomists across disciplines, and a critical under‐appreciation of the role that natural history data (and other forms of observational data, including Indigenous knowledge) play in the scientific process. In this paper, we demonstrate that natural history knowledge is integral to any competitive science program through a comprehensive review of the ways in which they continue to shape modern theory and the public perception of science. We do so by reviewing how natural history research has guided the disciplines of ecology, evolution, and conservation and how natural history data are crucial for effective education programs and public policy. We underscore these insights with contemporary case studies, including: how understanding the dynamics of evolutionary radiation relies on natural history data; methods for extracting novel data from museum specimens; insights provided by multi‐decade natural history programs; and how natural history is the most logical venue for creating an informed and scientifically literate society. We conclude with recommendations aimed at students, university faculty, and administrators for integrating and supporting natural history in their mandates. Fundamentally, we are all interested in understanding the natural world, but we can often fall into the habit of abstracting our research away from its natural contexts and complexities. Doing so risks losing sight of entire vistas of new questions and insights in favor of an over‐emphasis on simulated or overly controlled studies.
Effects of solar energy development on ants in the Mojave Desert
Authors: Grodsky Steven M. , Roeder Karl A. , Campbell Joshua W. 
Published: October 2023

AbstractLand‐use change from solar energy development may affect desert ecosystems and the soils, plants, and animals therein, yet our understanding of these interactions is nascent. With their ubiquity, criticality as ecosystem constituents, and sensitivity to environmental variation, ants may be useful study organisms for elucidating ecological effects of solar energy development in deserts. Our objectives were to disentangle the response of a desert ant community to solar energy development decisions and test the efficacy of ants as bioindicators at a solar power facility (392 MW) in the Mojave Desert, USA. We used pitfall traps to collect ants in treatments representing different solar energy development decisions, including variably intense site preparation practices: blading (i.e., bulldozing) and mowing, and establishment of undeveloped patches in solar fields, replicated across three power blocks comprising the facility and in undeveloped control sites surrounding the facility. We determined that ant abundance, species richness, Shannon Diversity Index, and functional richness were lower in bladed treatments than in all other treatments and controls. For most taxonomic and functional ant responses, we detected no difference between nonbladed treatments and controls; these results suggest that less intensive site preparation and increased spatial heterogeneity (i.e., undeveloped patches in solar fields) can reduce the negative effects of solar energy development on desert ants. However, our results indicate that ants may serve as useful bioindicators of the severity of anthropogenic disturbance from solar energy development in deserts, and indicator analysis signifies that solar energy infrastructure may negatively affect some species with high ecological value (e.g., harvester ants). Negative effects of solar energy development on ants can have significant implications for desert ecosystem function and integrity, but conservation‐minded solar facility design and construction may lead to avoidance of “bottom‐up” ecological ramifications of increased solar production during the renewable energy transition.
Stereochemistry of aminoacylated cardiolipins and phosphatidylglycerols from bacteria
Authors: Kyselová Lucie , Řezanka Tomáš 
Published: October 2023

AbstractHydrophilic interaction liquid chromatography (HILIC) connected with electrospray high‐resolution tandem mass spectrometry (MS) was used for the analysis of unusual amino acid (AA) substituted phosphatidylglycerols (PG) and cardiolipins (CL) in mesophilic and thermophilic bacteria. Individual peaks from the lipid class separation by HILIC were isolated and hydrolyzed to determine the absolute configuration of the aminoacyl side chain. The configuration of the aminoacyl side chain was assigned by indirect liquid chromatography (LC) enantiomer separation after the hydrolysis of the aminoacylated (aminoacyl) lipids using N‐(4‐nitrophenoxycarbonyl)‐l‐phenylalanine 2‐methoxyethyl ester as chiral derivatizing agent and reversed phase LC–MS for analysis. When two chromatographic methods were combined, less common AAs, such as d‐allo‐Ile and d‐allo‐Thr, were identified. The taxonomic classification of bacteria showed that bacteria of the family Bacillaceae (Bacillus and Geobacillus) produce branched‐chain AAs, that is, d‐allo‐Ile, d‐Ile, and d‐Leu. These AAs were present only in the genera Bacillus and Geobacillus and not in Alicyclobacillus acidoterrestris (family Alicyclobacillaceae). On the contrary, hydroxy AAs, that is, l‐ and d‐Thr, and l‐ and d‐allo‐Thr, were identified as aminoacyl‐PG and aminoacyl‐CL in A. acidoterrestris and were not present in the genera Bacillus and Geobacillus. Therefore, the complete analysis made it possible to identify the stereochemistry of AAs in aminoacyl PGs and CLs and use this fact for chemotaxonomy.