bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Effect of Virgin Rice Bran Oil (VRBO) on DoxorubicinInduced Cardiotoxicity in Wistar Rats
Authors: Prema S. , Verma Rakesh , Nagarwal Amritesh , Bharkatiya Meenakshi , Baghel Madhuri , Kishore Ladli , Wal Pranay , Gasmi Amin 
Published: January 2025

Objective:
The usage of doxorubicin (DOX), an antineoplastic drug that is frequently
used for the cure of cancer, is restricted to maximal doses due to its cardiac toxicity. Reactive
oxygen species produced by DOX result in lipid peroxidation and organ failure, ultimately
resulting in cardiomyopathy. Due to its high polyphenol content, virgin rice bran oil (VRBO) is
a diet nutritional supplement with a strong antioxidant. This study aimed to assess the potential
defense of VRBO against DOX-induced cardiotoxicity.

Methods:
VRBO and DOX injections were administered to thirty male Wistar rats for 42 days
after being randomly assigned to five groups.

Results:
The study demonstrated the cardioprotective effects of VRBO against doxorubicin
(DOX)-induced cardiotoxicity. VRBO (0.71 and 1.42 ml/kg) significantly improved the heart-tobody weight ratio, reduced elevated serum CK-MB and LDH levels by 18.4% and 52.7%, respectively, and increased HDL by 43.1%. ECG parameters also improved, with reductions in QT
interval (19%), ST interval (28%), and QRS complex (15%). VRBO enhanced systolic blood
pressure (up to 21%) and heart rate (7.1%). Antioxidant markers showed notable recovery, with
MDA levels reduced by 66.1%, while GSH, SOD, and catalase levels increased by 129.4%,
158.2%, and 84.8%, respectively.

Conclusion:
A cardioprotective benefit was found at middle and higher VRBO dosages. In order
to demonstrate the effectiveness of VRBO as a cardioprotective medication, further research on
dosage response and bioavailability is required.
Therapeutic Targeting of Quercetin to Breast Cancer Cells under In Vitro Conditions: A Systematic Review
Authors: Esmaeli Mojtaba , Ghanbari Ali 
Published: January 2025

Background:
Quercetin (QT) is an effective plant compound in treating various diseases,
including certain types of cancer. Therefore, this systematic review study was conducted to investigate
the positive effects of quercetin (QT) on different breast cancer cell lines under in vitro conditions.

Objective:
The purpose of this study was to explore the beneficial effects of quercetin (QT) on various
breast cancer cell lines in an in vitro setting.

Methods:
Using various databases, including PubMed, Scopus, Science Direct, and Google Scholar,
we searched for publications from 2018 to May 2024 based on relevant terms and keywords for
this systematic review. Inclusion criteria focused on English, open access, and original studies that
exclusively examined the effects of QT on breast cancer cell types in vitro.

Results:
From the initial search, 1308 publications were identified. However, only 46 met the inclusion
criteria and were included in this systematic review.

Conclusion:
In summary, quercetin (QT) shows anti-tumor effects on different breast cancer cell
lines by activating the PI3K/AKT/mTOR, IGF1/IGF1R, MAPK, Transforming Growth Factor-β
(TGFβ), and JAK/STAT1 pathways. Nonetheless, further extensive animal and clinical studies are
essential to draw definitive conclusions.
Exploring Pyridine-Based Schemes: A Comprehensive Review on their Synthesis and Therapeutic Applications
Authors: Balikai Amruta M. , M.R. Pradeep Kumar , Rajagopal Kalirajan , Alshehri Mohammed Ali , Obaidur Rab Safia , Nafady Mohamed H. , Bin Emran Talha 
Published: January 2025

Abstract:
Pyridine and its derivatives are six-membered aromatic rings containing nitrogen, which
are abundant in nature and indispensable in studying heterocyclic chemistry. They constitute significant
chemical substances with numerous applications. The application of pyridine derivatives by
incorporating metals in modern medicine is growing in relevance. Due to their convenient parallelization
and various testing capabilities in the chemical domain, pyridine derivatives have attracted
increased interest in the treatment of various disease states. This review aims to systematically
evaluate and highlight the recent advancements in the synthesis (conventional, synthetic, and green
approach) and biological activities of metal-based pyridine derivatives, including antioxidant, antimicrobial,
and antitumor activities, while identifying promising candidates for further drug development.
By consolidating all this knowledge underlying their biological effects, this review aims to
pave the way for future research endeavors and encourage the exploration of pyridine derivatives as
viable therapeutic agents across a diverse array of medical applications.
Isolation of Hemolymph-derived Antifungal Product from Marine Crab
Dromia dehaani
Authors: Ravichandran Samuthirapandian , Alagumuthu Manikandan , Suresh Jeevitha , Vadlaganti Vibha Sai 
Published: January 2025

Background:
Crab hemolymph are rich in medicinally important secondary metabolites.

Objectives:
The objective of this study was to isolate, identify, and establish the crab hemolymphderived secondary metabolites for the antifungal activity.

Methods:
Several brachyuran crabs were investigated against 10 pathogenic strains. The disc diffusion method was used to investigate hemolymph extracts to identify potential brachyuran crabs
showing antifungal activity. The moderately purified hemolymph was taken for RP-HPLC using a C18 column. The obtained GC-MS-NIST formula/compound details were used to unveil the possible
structures of obtained compounds. Individual compounds were confirmed by comparing the obtained
structures with 1H NMR & 13C NMR results. The isolated Sparsomycin was subjected to a molecular docking Crystal Structure of Fungal RNA Kinase (PDB ID: 5U32).Methods:

Results:
Notably, most of the crab species in this study exhibited activity against various strains of
fungi. The current findings demonstrated that the hemolymph of the crab Dromia dehaani exhibits
broad-spectrum activity against pathogenic fungi. The D. dehaani showed the uppermost antimicrobial activity, and the most potent extracts obtained from the sponge crab, D. dehaani, displayed activity against several fungal organisms that included Candida albicans and Aspergillus niger. D.
dehaani was selected for detailed investigations as the hemolymph of D. dehaani has the potential to
be developed as an anti-microbial agent to treat infections.

Conclusion:
The compounds isolated, identified, and established as antifungal agents could be the
future drugs for restricting major fungal infections.
Favourable Living Donor Kidney Transplantation Outcomes within a National Kidney Exchange Program: A Propensity Score Matching Analysis.
Authors: van de Laar Stijn C. , de Weerd Annelies E. , Bemelman Frederike J. , Idu Mirza M. , de Vries Aiko P.J. , Alwayn Ian P.J. , Berger Stefan P. , Pol Robert A. , van Zuilen Arjan D. , Toorop Raechel J. , Hilbrands Luuk B. , Poyck Paul P. , Christiaans Maarten H.L. , van Laanen Jorinde H.H. , van de Wetering Jacqueline , Kimenai Hendrikus J.A.N. , Reinders Marlies E.J. , Porte Robert J. , Dor Frank J.M.F. , Minnee Robert C. 
Published: January 2025

Background:
KEPs (kidney exchange programs) facilitate living donor kidney transplantations (LDKT) for patients with incompatible donors, who are typically higher risk than non-KEP patients because of higher sensitization and longer dialysis vintage. We conducted a comparative analysis of graft outcomes and risk factors for both KEP and non-KEP living donor kidney transplants.

Methods:
All LDKTs performed in the Netherlands between 2004-2021 were included. The primary outcome measures were one-, five- and 10-year death censored graft survival (DCGS). The secondary outcome measures were delayed graft function (DGF), graft function, rejection rates and patient survival. We used a propensity score matching model to account for differences at baseline.

Results:
Out of 7536 LDKTs, 694 (9%) were transplanted via the KEP. Ten-year graft survival was similar for KEP 0.916 (95% CI: 0.894 - 0.939) and non-KEP 0.919 (0.912 - 0.926, p = 0.82). We observed significant differences in five-year rejection (12% vs 7%), and five-year patient survival (KEP: 84%, non-KEP: 90%), which was non-significant after propensity score matching. Significant risk factors for lower graft survival included high donor age, re-transplantations, extended dialysis vintage, higher panel reactive antibodies, and nephrotic syndrome as the cause of end-stage kidney disease .

Conclusions:
Transplantation via KEP offers a viable alternative for patients lacking compatible donors, avoiding specific and invasive pre- and post-transplant treatments. KEP's similar survival rate to non-KEP suggests prioritizing KEP LDKT over deceased donor kidney transplantation, desensitization, and dialysis. However, clinicians should consider the identified risk factors when planning and managing pre- and post-transplant care to enhance patient outcomes. Thus, we advocate for the broad adoption of KEP and establishment in regions lacking such programs, alongside initiation and expansion of international collaborations.
Factors influencing consumers repurchase intention on e-commerce live streaming of agricultural products
Authors: Liu Ying , Fan Jing 
Published: January 2025

Abstract
Accompanied by the comprehensive promotion of the Internet and the prosperity of e-commerce, e-commerce live streaming of agricultural products is booming and has a promising market prospect. This study presents a research model aimed at investigating the factors influencing consumers repurchases of agricultural products via e-commerce live streaming. The research uses a questionnaire format and structural equation modelling to analyze data from 586 consumers in China. The results of the study show that information quality, product quality, logistics service quality, and ROO image have a positive effect on satisfaction and trust. Both satisfaction and trust have a positive effect on repurchase intention. Satisfaction and trust play a partial mediating role. This research theoretically enriches the influencing factors of consumers repurchase of agricultural products through e-commerce live streaming, and also provides development insights for e-commerce live streaming of agricultural products.
Los corresponsales extranjeros en Madrid durante la Guerra Civil: dinámicas e identidades
Authors: Barreiro Gordillo Cristina 
Published: January 2025

El comienzo de la Guerra Civil atrajo el interés mediático internacional. En un momento de fuertes tensiones entre fascismo y comunismo, muchos vieron el inicio del conflicto español como un campo de experimentación para un enfrentamiento de dimensiones mayores. Por este motivo, los principales medios internacionales enviaron a Madrid sus corresponsales más renombrados. Hemingway, Herbert, Matthews, Sefton Delmer, John Dos Passos o Mijail Kolstov fueron algunos de los corresponsales que estuvieron en España en este periodo. También encontramos corresponsales latinoamericanos en el conflicto como Binns o Cano Reyes y figuras femeninas como la mexicano-estadounidense Anita Brenner, que escribió numerosas crónicas desde España para Estados Unidos. En este artículo se pretende trazar un recorrido por la dinámica de trabajo que siguieron los corresponsales que estuvieron en Madrid desde julio de 1936 hasta abril de 1939. De este modo, se trata de comprender cómo las informaciones que salieron de la capital pasaron el filtro de censura y terminaron estableciendo unos parámetros mediatizados de la realidad española.
La frontera interior y el despliegue del Estado en el siglo XIX colombiano: dos documentos para la historia de Santa Rosa de Cabal
Authors: Nueva Ciencia 
Published: January 2025

Los textos que transcribimos en esta ocasión para la sección Anales son el testimonio del proceso en el que se encontraba el territorio de la actual Colombia en durante la segunda mitad del siglo XIX. Hacia la década de 1840, una vez superada “la Guerra de los Caudillos Supremos”, la república de la Nueva Granada debía enfrentar su consolidación como Estado-nación, lo que requería no solo la organización política de su territorio, sino también su integración y expansión hacia áreas menos controladas. En este marco, el territorio del Cauca jugó un papel central al proponerse como punto estratégico para la creación de nuevos asentamientos en su frontera norte, un espacio en transformación que conectaba con la histórica región de Antioquia. Este proceso no solo respondía a la necesidad de consolidar las fronteras internas, sino también de controlar territorios en disputa poco integrados al control estatal y a instituciones de poder que en muchos casos se habían establecido desde el temprano periodo monárquico.
Preliminary exploration of ChatGPT-4 shows the potential of generative artificial intelligence for culturally tailored, multilingual antimicrobial resistance awareness messaging
Authors: Akinyede Oluwaseun , Yustyniuk Valeriia , Ochwo Sylvester , Aworh Mabel , Wilkins Melinda 
Published: January 2025

Abstract

Objective
Antimicrobial resistance (AMR), a global threat driven by factors such as improper antimicrobial use in humans and animals, is projected to cause 10 million annual deaths by 2050. For behavior change, public health messages must be tailored for diverse audiences. Generative AI may have the potential to create culturally and linguistically suited AMR awareness messages. This study assesses ChatGPT-4's capability for crafting such content.

Methods
4 veterinary public health professionals from diverse linguistic and cultural backgrounds identified top AMR contributors and audiences in their countries. A fifth person developed and refined ChatGPT-4 prompts to create AMR awareness content in US English, Ukrainian, Luganda, Ugandan English, Yoruba, and Nigerian Pidgin, using behavior change models. The content was rated for accuracy, applicability, language, cultural fit, originality, clarity, persuasiveness, and overall quality.

Results
ChatGPT-4 created 2 content types (long and short) per language for social media, television ads, and WhatsApp. Quality ranged from poor to excellent. Shorter content outperformed longer ones. Performance varied across languages, with abysmal results for Yoruba and excellent for Pidgin. Problematic issues like simplistic language and inappropriate terminology were identified.

Conclusions
ChatGPT-4 has the potential to generate content and training aids. However, the varied quality requires professional verification. Future research should optimize prompts and incorporate expert and audience insights for better results. These preliminary findings should be interpreted cautiously due to the small sample size and subjectivity.

Clinical Relevance
ChatGPT-4 can quickly create tailored content for global AMR awareness. More research is needed to explore generative AI for One Health messaging.
Description of Methodology for Testing the Synergistic and Additive Effects of Antibiotics in Vitro
Authors: Kmiecikowski Paweł Z. , Gabriel Aniela , Depka Dagmara , Bogiel Tomasz 
Published: January 2025

Abstract
Given the dynamic growth of antibiotic resistance observed over the past few decades, new therapeutic methods for life-threatening infections are crucial. Effective treatment of infections caused by multidrug-resistant microorganisms increasingly requires the use of last resort drugs, and new antibiotics generate resistance in less time than it takes to bring them to the therapy. Therefore it is advisable to seek solutions using currently available antibiotics. Effective therapy of infections with multidrug-resistant microorganisms may be enabled by the use of additive and synergistic interactions, resulting from the combination of different groups of antibiotics with the same or different modes of action – including those to which a particular bacterial strain is resistant. This paper describes methods for determining the synergistic and additive effects of antibiotics in vitro, including the CombiANT method under testing. The purpose of this study is to present possible methods for determining the additive and synergistic effects between antibiotics in vitro and to propose appropriate laboratory procedures for their use. This paper reviews the latest literature on methods for determining the antimicrobials interactions. Clinical studies indicate significant benefits of using the phenomenon of antibiotic addition or synergy in clinical practice, not only improving the effectiveness of therapy, but also minimizing side effects and reducing the risk of developing de novo antibiotic resistance. Despite the significant problem of increasing antibiotic resistance level, clinical practice still lacks clearly standardized methods for determining synergism. Further research is needed to determine the most beneficial standard available for a wide range of microbiology diagnostic facilities.
Causes and Consequences of Peri-Urban Land Conflicts in Ethiopia: The Case of Mekelle City
Authors: Araya Negash , Girma Birhanu 
Published: January 2025

Abstract
In Ethiopia, like in other developing countries, land conflicts in urban fringes are usually subject to severe disputes. Different land tenure and administration systems may clash as land use converted from rural to urban status, resulting in disagreements, contestations, and occasional violence. Nevertheless, the specific reasons for peri-urban land conflict are not well understood in developing countries so far because of the political use of regularizing land tenure and the control exercised by a corporatist system of the government. Hence, accordingly, this paper explores the causes and consequences of peri-urban land conflicts in Mekelle City: Enderta district. A case study was used to answer the research question, while questionnaire and document analysis were the main sources of primary and secondary data. According to the research’s findings, overlapping legal and governance frameworks, a variety of property rights claims, local power dynamics, and self-serving individual interests are the main drivers of peri-urban land conflicts. Moreover, lowering tax revenue for the state or municipality, raising expenses, impeding investment, and causing conflict were the consequences of peri-urban land conflicts.
Getting Personal about Personal Insurance
Authors: Driver Tania , Brimble Mark , Freudenberg Brett , Hunt Katherine 
Published: January 2025

Abstract
This article reports research into an area of insurance, personal insurance. This is important as some research suggests that insurance literacy could be related to the level of insurance purchased. To consider this potential relationship this article reports a detailed analysis of interviews with consumers and financial advisers in Australia about their consideration of personal insurance products. The findings reveal financial advisers consider that consumers have very low levels of insurance literacy, which they believe is linked to underinsurance. Consumers demonstrated low levels of personal insurance literacy, with trauma insurance being the least understood, and this may lead to strategies to improve insurance literacy and address concerns about under- or over-insurance.
Practical analysis of using PPPH and raPPPid for Precise Point Positioning in Europe
Authors: Saber Mohamed , El-Mewafi Mahmoud , Awad Ahmed 
Published: January 2025

Abstract
Assessing the reliability of using open-source software packages for post-processing of the Global Navigation Satellite System (GNSS) is essential since GNSS modernization has the potential to assist satellite navigation users. The purpose of this study is to evaluate the accuracy of using two MATLAB-based programs, raPPPid and PPPH for precise point positioning in Europe. Data from 12 MGEX stations over two days were used, with one day dedicated to each of the 6 stations and a 30-second observation interval. The data were post processed by PPPH and raPPPid programs and a comparison was made to evaluate the results accuracy produced by each software and the ones acquired from MGEX stations. Convergence time was also estimated. By comparing the root mean square error (RMSE) values for North, East and Up directions estimated by PPPH and raPPPid, it was found that raPPPid gives more accurate results where the RMSE in N direction estimated by raPPPid varied from 0.5 cm to 1.9 cm; however, RMSE in N direction estimated by PPPH varied from 0.7 cm to 2.8 cm. RMSE in E direction estimated by raPPPid varied from 0.4 cm to 3.3 cm, but RMSE in E direction estimated by PPPH varied from 0.5 cm to 3.7 cm. RMSE in Up direction estimated by raPPPid varied from 0.8 cm to 5.2 cm, while RMSE in Up direction estimated by PPPH varied from 0.9 cm to 5.5 cm. 3D Positioning error was also estimated by both software and it was found that the 3D positioning error estimated by raPPPid varied from 0.2 cm to 2.2 cm, whereas the 3D positioning error estimated by PPPH varied from 0.9 cm to 4.1 cm. Finally, the average convergence time achieved by raPPPid was 16.5 minutes, while the average convergence time achieved by PPPH was 32 minutes.
Real-time geo-decisional system for risk and disaster management in Madagascar
Authors: Rakotoarison Tsiorinantenaina René , Hajalalaina Aimé Richard 
Published: January 2025

Abstract
Climate change is intensifying extreme phenomena, and the world is increasingly vulnerable to a variety of disasters whose impacts are considerable and varied over time, from one place to another and from one community to another. Due to its geographical location, Madagascar is the most cyclone-prone country in Africa and the ninth most vulnerable country in the world. Almost every year, Madagascar is hit by cyclones, causing loss of life and property for the population. In terms of prevention, Madagascar already has an early warning system to inform the population, but during a crisis, it still lacks a decision support system for rapid, real-time intervention to minimize damage. In this paper, we propose a real-time geo-decision support system based on real-time data integration, real-time ETL and real-time cube building. In the proposed architecture, continuous data ˚ow is required for real-time data integration. The proposed real-time ETL unit is composed of the capitalization of risk analysis experiments to ensure their reusability, as well as the insertion of processing parallelization to optimize the processing time of voluminous data. The real-time SOLAP unit consists of real-time cube formation using a spatial database that stores spatio-temporal data from a given point in time, with query optimization using materialized query technology. Our prototype uses NASA’s weather data streaming service via an API. The ETL is written in a Matlab script and loads the data into a spatial database in Postgresql after processing. A web mapping application queries the constitution of a cube and displays the result for visualization.