bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potensi Terapi Stem Cells Jaringan Adiposa dari Limbah Sedot Lemak untuk Regenerasi Paru-Paru Pasca Terpapar COVID-19
Authors: Ismi Alfita Ramdiyati , Haryanto Haryanto , Bahari Sandya Firman Vira , Hakim Mohammad Zayyan Firdausy 
Published: November 2023

COVID-19 merupakan penyakit menular yang disebabkan oleh virus SARS-CoV-2 yang pertama kali ditemukan di Wuhan-Tiongkok pada Desember 2019 sampai 21 September 2021 telah dilaporkan >219 juta positif dan >4,55 juta kematian. Walaupun sudah dinyatakan sembuh namun fungsi organ yang terinfeksi tidak bisa kembali optimal seperti semula. Terapi stem cells menjadi salah satu upaya yang sedang dikembangkan dan memiliki potensi untuk membantu regenerasi paru-paru penyintas COVID-19 dengan memperbaiki kerusakan sel akibat infeksi virus SARS-CoV-2. Tujuan penulisan ini adalah menjelaskan strategi mekanisme pengarahan dan optimalisasi mesenchymal stem cells (MSCs) dari derivat adiposa sedot lemak untuk terapi regenerasi paru-paru pasca terpapar COVID-19. Metode penulisan penelitian ini menggunakan studi litelatur, penelusuran data dengan cara komparasi studi pustaka jurnal, artikel, e-book berbahasa Indonesia dan Inggris, dilakukan secara skrining kata kunci. MSCs diisolasi dari adiposit hasil sedot lemak, lalu disentrifugasi untuk diambil lapisan paling bawah dan dikonfirmasi secara berkala sebelum dikultur pada flask dengan medium kultur sampai tahap konfluensi dan siap dipanen untuk digunakan sebagai sumber terapi. Sebelum dilakukan injeksi MSCs pasien diberikan injeksi intramuscular sebanyak 25mg promethazine hydrochloride untuk mencegah alergi, MSCs diinjeksikan dengan interval 2 kali selang 5 hari dengan dosis standar 1x106 sel mononuklear per kilogram berat badan. Hasil CT scan yang dilakukan pada 25 pasien terapi MSCs, 16 pasien menunjukkan paru-parunya beregenerasi sehingga aman efikasi dan tidak menimbulkan efek samping, Disimpulkan bahwa terapi MSCs derivat adiposa menjadi harapan baru dalam regenerasi paru-paru pasca terpapar COVID-19.
KAJIAN PENGGUNAAN OBAT ANTI HIPERTENSI PADA PASIEN DENGAN GANGGUAN FUNGSI GINJAL DI RUMAH SAKIT DAERAH PASAR REBO
Authors: Fathonah Diyah , Tola Sakura Muhammad 
Published: November 2023

Latar belakang Antihipertensi merupakan obat yang diberikan pada pasien terdiagnosis hipertensi, pada sebagian pasien terdapat pula gagal ginjal sebagai komplikasi dari hipertensi yang sudah lama berada pada tubuh pasien. Sehingga terdapat obat antihipertensi yang memiliki efek melindungi ginjal (renoprotektif) berupa ACEI dan ARB.Tujuan Penelitian ini bertujuan untuk mengetahui penggunaan obat antihipertensi pada pasien gangguan fungsi ginjal rawat inap di RSUD Pasar Rebo dan untuk mengetahui pandangan Islam tentang hukum penggunaan obat antihipertensi.Metode. Jenis penelitian ini merupakan penelitian observasional retrospektif menggunakan data sekunder dari rekam medis. Populasi dan sampel penelitian ini menggunakan total sampling dengan kriteria inklusi pasien dewasa dengan diagnosa gangguan fungsi ginjal dengan hipertensi di instalasi rawat inap yang mendapat terapi obat anti hipertensi golongan obat, jenis obat, serta penggunaan obat sebagai monoterapi maupun terapi kombinasi di Rumah Sakit Umum Daerah Pasar Rebo periode tahun 2016.Hasil dan Diskusi penelitian yang dilakukan di Rumah Sakit Umum Pasar Rebo diperoleh jumlah pasien sebanyak 123 pasien yang memenuhi kriteria inklusi dan eksklusi. Presentase penggunaan obat berdasarkan pasien gangguan fungsi ginjal didapatkan laki-laki (61%), dan perempuan (39%). Presentase pasien gangguan fungsi ginjal berdasarkan usia 18-34 tahun didapat (5%), usia 35-44 tahun (12%), usia 45-54 tahun (39%), dan usia 55-64 tahun (44%). Presentasi pasien terdiagnosis gangguan fungsi ginjal berdasarkan CKD yaitu (83%) dan AKI (17%). Presentasi nilai GFR pada pasien hipertensi dengan gangguan fungsi ginjal yaitu ? 90 ml/min/1,73 m2 (1%), 60-89 ml/min/1,73 m2 (7%), 30-59 ml/min/1,73 m2 (21%), 15-29 ml/min/1,73 m2 (26%), dan ? 15 ml/min/1,73 m2 (45%). Presentase jenis obat pada pasien gangguan fungsi ginjal yaitu ACEi (7%), ARB (17%), Beta Blocker (15%), CCB (26%), dan Diuretik ( 39%). Presentase golongan obat menurut variasi penggunaan obat antihipertensi yaitu monoterapi sebanyak (25%), Kombinasi 2 obat (18,8%), kombinasi 3 obat (16,8%), kombinasi >3 obat (30,4)Kesimpulan Presentase ketepatan pemilihan pada penggunaan obat antihipertensi yaitu didapatkan (100%). Presesntase ketepatan indikasi penatalaksaan pada penggunaan obat pasien hipertensi dengan gangguan fungsi ginjal yaitu (100%)Presentase ketepatan dosis pada penggunaan obat anhipertensi didapatkan terdapat kelebihan dosis sebanyak (2%). Kata Kunci : Gangguan Fungsi Ginjal, Hipertensi, Anti hipertensi, Pasien, Rumah Sakit
EFEK LISTRIK TEGANGAN RENDAH TERHADAP PERTUMBUHAN BAKTERI Escherichia Coli
Authors: Firmansyah Dedy 
Published: November 2023

Bakteri Escherichia coli merupakan salah satu jenis bakteri gram negatif dan bersifat fakultatif anaerob.Bakteri yang ditemukan oleh Theodor Escherich ini biasanya hidup di usus besar manusia berfungsi untuk menjaga kesehatan sistem pencernaan. Bakteri ini umumnya tidak berbahaya,walaupun begitu tingkat kewaspadaan terhadap Escherichia coli perlu tetap diterapkan.Prevalensi infeksi karena bakteri Escherichia coli sangat tinggi di negara berkembang dengan perkiraan angka kejadian lebih dari 100 kasus per 100.000 penduduk (WHO, 2006). Penelitian ini merupakan penelitian eksperimental dengan tujuan untuk mengetahui efek listrik tegangan rendah terhadap pertumbuhan bakteri Escherichia coli.Perlakuan menggunakan perlakuan sebanyak lima batch yang masing-masing batch terdiri dari lima tabung. Setiap 1 batch penelitian menggunakan tegangan listrik yang sama selama 1 jam dengan mengevaluasi pemantauan setiap 20 menit, 40 menit, dan 60 menit.Pada batch 1,digunakan tegangan listrik 0,4 volt sebanyak lima tabung,batch ke-2 dilanjutkan dengan tegangan listrik 0,5 volt sebanyak lima tabung,batch ke-3 dengan menggunakan tegangan listrik 0,7 volt,dan batch ke-4 dengan menggunakan tegangan listrik 0,8 volt dan pada batch ke-5 dengan menggunakan tegangan listrik 1 volt sebanyak lima tabung.Dari hasil penelitian ini didapatkan hasil bahwa listrik tegangan rendah dapat membunuh bakteri Eschericia coli dengan tegangan listrik optimal sebesar 0,5 volt,arus listrik 40 mA dan waktu pemantauan optimal yaitu 20 menit.
Time Series Forecasting of Top 3 Ranking Cryptocurrencies
Authors: Setiawan Ridwan , Julianto Indri Tri , Roji Fikri Fahru 
Published: November 2023

Cryptocurrency has become a phenomenon worldwide. Although not all countries have legalized it, it is considered a promising investment asset. Currently, there are three top-ranking cryptocurrencies: Bitcoin, Ethereum, and Tether. This research aims to compare the performance of five forecasting algorithms, namely Autoregressive Integrated Moving Average (ARIMA), Neural Network, Support Vector Machine, Linear Regression, and Generalized Linear Model, using the dataset of Bitcoin, Ethereum, and Tether cryptocurrencies. The research methodology employed is Knowledge Discovery In Databases (KDD). The technique involves assessing the performance based on the Root Mean Square Error (RMSE) and comparing the results to find the most optimal model performance. The research findings indicate that for Bitcoin cryptocurrency, the Neural Network algorithm produced the most optimal results with an RMSE of 9180.534. For Ethereum cryptocurrency, the Neural Network algorithm demonstrated the best performance with an RMSE value of 537.528. Furthermore, for Tether cryptocurrency, the ARIMA algorithm yielded the best performance with an RMSE value of 0.003. Keywords – bitcoin, cryptocurrency, ethereum, forecasting, tether
The Development of Digital Comics Learning Media Based on Scientific Approach as Character Strengthening for Grade 2 Elementary School
Authors: Rosyada Tanti Nur , Asmarani Ratih 
Published: November 2023

The development of digital comic media as an effort to provide innovation and education in character education in learning material on religious diversity is based on several gaps, including: 1) students' lack of understanding of religious diversity in Indonesia, 2) lack of student understanding of tolerance, 3) The way teachers provide religious diversity material is conventional and only based on books. The purpose of this research to find out digital comic media development and implementation at SDN Kepanjen 2 Jombang.
Based on the problems that have been described, the development aims to produce valid digital comic media for grade II students of SDN Kepanjen 2 Jombang. The development of this digital comic media used the ADDIE development model. There are 5 stages in the development process that have been carried out in this research, namely 1) analysis, 2) design, 3) development, 4) implementation, and 5) evaluation. The assasement of digital comic media was carried out by material experts, media experts, educators, and second grade students at SDN Kepanjen 2 Jombang.
The results of the research showed that the development of digital comic media show that the percentage obtained from material expert validators, which is 85% with a very valid category and suitable for use without improvement, the value obtained from media expert validators, is 91.25% with a very valid category and suitable for use without improvement. but there are still revisions. Furthermore, the results of the educator's trial 91% with a very valid category and suitable for use without improvement. The results of field trials were carried out with 20 students with a percentage of 88% in the very interesting category. Based on the results of the data analysis, it can be concluded that the development of digital comic media is fit and possible to used as a media learning.
The Effect Of Cooperative Type Pair Check On The Mathematics Result For Grade IV
Authors: Musfiroh Siti A'yunin , Rahma Pratiwi Emy Yunita 
Published: November 2023

This research purpose to determine the effect of the pair check type of cooperative learning model on the mathematics learning outcomes of fourth grade. This quantitative research of pre-experimental research design that used in the form of a one group pretest posttest design. The population is all of the students in SDN Sugihwaras I. The sample in this study consisted in the entire class IV, with the generally 23 students. The date collection used a test and questionnaire method. The form of a written test have a form of multiple choice, while the questionnaire to have a form of a statement. The result of this study can be several conclusion, including : (1) the ability to understand the material before using the pair check type cooperative learning model in fourth grade students was generally categorized as moderate with the average score obtained by students is 63.65. (2) the ability to understand the material after using the pair check type cooperative learning model in fourth grade students was generally categorized as capable, this is evidenced by the average score obtained by students, which is 92.35. (3) the value of learning mathematics on the subject for fourth grade students showed that the significant value of 0,000. The significant value indicates 0,000 < 0,05 so H0 is rejected and H1 is accepted, which means that the significant value when used of the pair check type cooperative learning model on the fourth grade students mathematics learning outcomes at SDN Sugihwaras I Ngoro Jombang.
Examining the urban regeneration of public cultural space using multi-scale geospatial data: a case study of the historic district in Jinan, China
Authors: Xu Yabing , Tong Hui , Chen Meng , Rollo John , Zhang Ruijie 
Published: November 2023

Introduction: Historical-cultural landscapes and urbanscapes integrate regional culture, collective memory, urban patterns, living habits, and other related historical and spatial information, and are important places for expressing the values of urban space. This study analyzes cultural landscapes and urbanscapes from the perspective of spatial values, taking the Baihuazhou historic and cultural district in Jinan as an example to analyze the spatial identification of public cultural space. The significance of this research lies in examining the urban regeneration of public cultural space using multi-scale geospatial data from both an objective and subjective perspective. This methdology is based on a large body of previous literature in relation to cultural heritage, and draws on a comprehensive understanding of the field.Methods: This study applies spatial syntax, visual graph, and survey analyses, focusing on urban spatial patterns, spatial culture, and spatial memory as heritage values.Results: The analysis results reveal that historic districts generally do not have good accessibility, predominantly because of the disorganized texture of the buildings and absence of spatial consistency.Discussion: There should be improved dynamic spatial identification and accessibility in older urban environments and enhancement of local spatial identification memory by increasing sightline accessibility. Based on consideration of values, corresponding suggestions are made from the three perspectives of urban space, cultural landscapes, and local collective memories to provide a reference for the protection of the Baihuazhou historic district and promote the preservation and development of similar heritage spaces.
Association between serum uric acid level and bone mineral density in men more than 50 years of age
Authors: Kim Sujin , Lee Seulki , Kwon Hyuktae 
Published: November 2023

BackgroundThe results of previous studies on the association between serum uric acid levels and bone mineral density and the risk of osteoporosis are controversial. Fat free mass (FFM) is more strongly associated with bone mineral density (BMD) than it is with body fat mass (BFM). Skeletal muscle mass is assumed to contribute indirectly to the relationship between serum uric acid levels and BMD. Therefore, we aimed to evaluate the association between serum uric acid levels and BMD and abnormal BMD (at least osteopenia) by considering body composition in men aged ≥ 50 years.MethodsThis was a retrospective observational cross-sectional study. We used data obtained from 2,991 men aged ≥50 years who completed questionnaires, anthropometric surveys, laboratory tests, and bone mineral density scans. A subgroup analysis of 1,135 men who additionally underwent body composition data analysis using Inbody® was performed. Multiple linear regression analysis was used to explore the relationship between serum uric acid levels and BMD at three sites (L1-L4, Femur neck, Femur total). In addition, multiple logistic regression analysis was performed to determine the association of serum uric acid levels with abnormal BMD (at least osteopenia).ResultsPositive correlations between serum uric acid levels and BMD at the three sites (L1-L4, Femur neck, Femur total) were observed in unadjusted and fully adjusted models except the BMD of the femoral neck (P-value=0.054).Furthermore, FFM and skeletal muscle mass index (SMI) showed positive association with serum uric acid level and BMD at three sites, with statistical significance. An increase in serum uric acid level was associated with a lower risk of abnormal BMD after adjusting for confounders including FFM and SMI.ConclusionSerum uric acid level was positively associated with BMD at three sites and had a protective effect against abnormal BMD after adjusting for multiple confounders, including FFM and SMI, in men aged ≥ 50 years.
Disrespect and abuse during childbirth in East Hararghe Zone public health facilities, eastern Ethiopia: a cross-sectional study
Authors: Usso Ahmedin Aliyi , Adem Hassen Abdi , Alemu Addisu , Mohammed Aminu 
Published: November 2023

BackgroundCompassionate and respectful maternity care during childbirth has been identified as a potential strategy to prevent and reduce maternal mortality and morbidity. Despite its importance, there is a paucity of information on the level of disrespect and abuse meted out to mothers in eastern Ethiopia. This study assesses the level of disrespect and abuse suffered by women during childbirth, and the associated factors, in public health facilities in the rural East Hararghe Zone in eastern Ethiopia.MethodsA cross-sectional study was conducted among 530 women who gave birth in 20 public health facilities in the East Hararghe Zone during the period between 1 April and 30 April 2020. Data were collected using a validated questionnaire. Bivariable and multivariable binary logistic regression analyses were employed to identify the factors associated with disrespect and abuse during childbirth. Adjusted odds ratio (AOR) (95% CI) was used to report this association, and statistical significance was set at P &lt; 0.05.ResultsOverall, 77% (95% CI: 73%–81%) of women reported at least one type of disrespect and abuse during childbirth in the East Hararghe Zone public health facilities. In this study, factors such as households having an average monthly income of below 57.22 USD (AOR = 2.29, 95% CI: 1.41–3.71), mothers residing at more than 30 min away from a nearby health facility (AOR = 2.10, 95% CI: 1.30–3.39), those not receiving antenatal care (AOR = 4.29, 95% CI: 2.17–8.52), and those giving birth during nighttime (AOR = 2.16, 95% CI: 1.37–3.41) were associated with at least one type of disrespect and abuse during childbirth.ConclusionMore than three in every four women who gave birth in the East Hararghe Zone public health facilities were disrespected and abused during childbirth. Encouraging all pregnant women to pay attention to antenatal care visits and improving the quality of healthcare service during nighttime in all health facilities will be essential for preventing and reducing disrespect and abuse and its negative consequences.
A novel anti-galectin-9 immunotherapy limits the early progression of pancreatic neoplastic lesions in transgenic mice
Authors: Quilbe Alexandre , Mustapha Rami , Duchêne Belinda , Kumar Abhishek , Werkmeister Elisabeth , Leteurtre Emmanuelle , Moralès Olivier , Jonckheere Nicolas , Van Seuningen Isabelle , Delhem Nadira 
Published: November 2023

BackgroundPancreatic adenocarcinoma (PDAC) is a devastating disease with an urgent need for therapeutic innovation. Immune checkpoint inhibition has shown promise in a variety of solid tumors, but most clinical trials have failed to demonstrate clinical efficacy in PDAC. This low efficacy is partly explained by a highly immunosuppressive microenvironment, which dampens anti-tumor immunity through the recruitment or induction of immunosuppressive cells, particularly regulatory T cells (Tregs). In this context, our laboratory has developed a novel immunotherapeutic strategy aimed at inhibiting the suppressive activity of Tregs, based on a patented (EP3152234B1) monoclonal antibody (mAb) targeting galectin-9 (LGALS9).Materials and methodsCD4+ conventional T cells (TCD4 or Tconv), Treg ratio, and LGALS9 expression were analyzed by immunohistochemistry (IHC) and cytometry in blood and pancreas of K-rasLSL.G12D/+;Pdx-1-Cre (KC) and K-rasWildType (WT);Pdx1-Cre (WT) mice aged 4–13 months. Pancreatic intraepithelial neoplasm (PanIN) progression and grade were quantified using FIJI software and validated by pathologists. The anti-galectin-9 mAb was validated for its use in mice on isolated murine C57BL/6 Treg by immunofluorescence staining and cytometry. Its specificity and functionality were validated in proliferation assays on rLGALS9-immunosuppressed murine Tconv and in suppression assays between murine Treg and Tconv. Finally, 2-month-old KC mice were treated with anti-LGALS9 and compared to WT mice for peripheral and infiltrating TCD4, Treg, and PanIN progression.ResultsIHC and cytometry revealed a significant increase in LGALS9 expression and Treg levels in the blood and pancreas of KC mice proportional to the stages of precancerous lesions. Although present in WT mice, LGALS9 is expressed at a basal level with low and restricted expression that increases slightly over time, while Treg cells are few in number in their circulation and even absent from the pancreas over time. Using our anti-LGALS9 mAb in mice, it is shown that (i) murine Treg express LGALS9, (ii) the mAb could target and inhibit recombinant murine LGALS9, and (iii) neutralize murine Treg suppressive activity. Finally, the anti-LGALS9 mAb in KC mice reduced (i) LGALS9 expression in pancreatic cancer cells, (ii) the Treg ratio, and (iii) the total surface area and grade of PanIN.ConclusionWe demonstrate for the first time that an anti-LGALS9 antibody, by specifically targeting endogenous LGALS9 tumor and exogenous LGALS9 produced by Treg, was able to limit the progression of pancreatic neoplastic lesions in mice, opening up new prospects for its use as an immunotherapeutic tool in PDAC.
Challenges of fully online learning for dermatology education: a retrospective study
Authors: Meng Yunfang , Sun Mingxia , Guo Jing , Jiao Jing , Dang Ningning 
Published: November 2023

BackgroundBlended learning has proven to be an effective teaching strategy. During the COVID-19 pandemic in 2019, educational institutions worldwide switched to online learning. However, there is limited research on the effectiveness of blended learning and fully online learning. This study aims to evaluate and compare whether pure online learning is as effective as traditional blended learning by taking the example of dermatology education.MethodsThe researchers compared traditional blended learning and fully online learning by evaluating the achievement scores of undergraduate students in a dermatology course in the academic years 2019 and 2020, respectively, at the Shandong First Medical University, China. In 2019, students undertook small private online courses (SPOCs) combined with face-to-face teacher-led learning. In 2020, live teacher-led learning replaced face-to-face teacher-led learning. The researchers also conducted a questionnaire survey in 2020.ResultsThe scores of students in 2019 were significantly higher than in 2020 (p = 0.002). There was no significant difference in the distribution of achievement variance in the scores between the two academic years. In the questionnaire survey, the majority of the students rated highly the fully online education mode and responded that pure online learning enhanced their self-study ability.ConclusionThe present study shows that fully online learning currently does not perform as well as traditional blended learning in terms of examination scores due to some limitations. However, pure online education has several advantages over traditional blended education. Online courses should be improved to ignite students’ interest and increase their learning efficiency.