bluuebunny/crossref_metadata_2025_split huggingface dataset:
Additive Manufacturing of High‐Temperature Hybrid Electronics via Molecular‐Decomposed Metals
Authors: Khuje Saurabh , Alshatnawi Firas , Smilgies Detlef , Alhendi Mohammed , Islam Abdullah , Armstrong Jason , Yu Jian , Poliks Mark , Ren Shenqiang 
Published: October 2023

AbstractAs the modern electronic technology extends into operating in harsh working conditions, it calls for a system that is capable of uncompromising performance in extreme environments, thus providing a strong motivation to look for advanced materials and electronics with the capability of high‐throughput and rapid prototyping. Coupled with additive manufacturing, molecular decomposition metals bypass the challenging oddities of traditional material‐limited and thermally initiated metalworking, enabling high throughput and rapid prototyping of stoichiometry and composition‐controlled metals. Here, a new paradigm for the design and additive manufacturing of copper metallic alloy materials onto ceramics is described by printing molecular decomposable metal materials, capable of withstanding thermo‐mechanical loading, operating in extreme environments in static and dynamic conditions. The resulting printed hybrid electronics are electrically stable for 25 h of aging at 1000 °C. This curious fact paves a way for printed antenna and sensor electronics that reliably operate up to 1000 °C. These results can be further extended to establish other printable molecular decomposable materials as a platform for rapid prototyping of high temperature electronics that are suitable for harsh environments.
Leveraging Semiconducting Polymer Nanoparticles for Combination Cancer Immunotherapy
Authors: Wu Jiayan , Pu Kanyi 
Published: October 2023

AbstractCancer immunotherapy has become a promising method for cancer treatment, bringing hope to advanced cancer patients. However, immune‐related adverse events caused by immunotherapy also bring heavy burden to patients. Semiconducting polymer nanoparticles (SPNs) as an emerging nanomaterial with high biocompatibility, can eliminate tumors and induce tumor immunogenic cell death through different therapeutic modalities, including photothermal therapy, photodynamic therapy, and sonodynamic therapy. In addition, SPNs can work as a functional nanocarrier to synergize with a variety of immunomodulators to amplify anti‐tumor immune responses. In this review, SPNs‐based combination cancer immunotherapy is comprehensively summarized according to the SPNs’ therapeutic modalities and the type of loaded immunomodulators. The in‐depth understanding of existing SPNs‐based therapeutic modalities will hopefully inspire the design of more novel nanomaterials with potent anti‐tumor immune effects, and ultimately promote their clinical translation.
Using Human‐Induced Pluripotent Stem Cell Derived Neurons on Microelectrode Arrays to Model Neurological Disease: A Review
Authors: Lv Shiya , He Enhui , Luo Jinping , Liu Yaoyao , Liang Wei , Xu Shihong , Zhang Kui , Yang Yan , Wang Mixia , Song Yilin , Wu Yirong , Cai Xinxia 
Published: October 2023

AbstractIn situ physiological signals of in vitro neural disease models are essential for studying pathogenesis and drug screening. Currently, an increasing number of in vitro neural disease models are established using human‐induced pluripotent stem cell (hiPSC) derived neurons (hiPSC‐DNs) to overcome interspecific gene expression differences. Microelectrode arrays (MEAs) can be readily interfaced with two‐dimensional (2D), and more recently, three‐dimensional (3D) neural stem cell‐derived in vitro models of the human brain to monitor their physiological activity in real time. Therefore, MEAs are emerging and useful tools to model neurological disorders and disease in vitro using human iPSCs. This is enabling a real‐time window into neuronal signaling at the network scale from patient derived. This paper provides a comprehensive review of MEA's role in analyzing neural disease models established by hiPSC‐DNs. It covers the significance of MEA fabrication, surface structure and modification schemes for hiPSC‐DNs culturing and signal detection. Additionally, this review discusses advances in the development and use of MEA technology to study in vitro neural disease models, including epilepsy, autism spectrum developmental disorder (ASD), and others established using hiPSC‐DNs. The paper also highlights the application of MEAs combined with hiPSC‐DNs in detecting in vitro neurotoxic substances. Finally, the future development and outlook of multifunctional and integrated devices for in vitro medical diagnostics and treatment are discussed.
A Novel Biosensing Approach: Improving SnS2 FET Sensitivity with a Tailored Supporter Molecule and Custom Substrate
Authors: Nisar Sobia , Basha Beriham , Dastgeer Ghulam , Shahzad Zafar M. , Kim Honggyun , Rabani Iqra , Rasheed Aamir , Al‐Buriahi M. S. , Irfan Ahmad , Eom Jonghwa , Kim Deok‐kee 
Published: October 2023

AbstractThe exclusive features of two‐dimensional (2D) semiconductors, such as high surface‐to‐volume ratios, tunable electronic properties, and biocompatibility, provide promising opportunities for developing highly sensitive biosensors. However, developing practical biosensors that can promptly detect low concentrations of target analytes remains a challenging task. Here, a field‐effect‐transistor comprising n‐type transition metal dichalcogenide tin disulfide (SnS2) is developed over the hexagonal boron nitride (h‐BN) for the detection of streptavidin protein (Strep.) as a target analyte. A self‐designed receptor based on the pyrene‐lysine conjugated with biotin (PLCB) is utilized to maintain the sensitivity of the SnS2/h‐BN FET because of the π–π stacking. The detection capabilities of SnS2/h‐BN FET are investigated using both Raman spectroscopy and electrical characterizations. The real‐time electrical measurements exhibit that the SnS2/h‐BN FET is capable of detecting streptavidin at a remarkably low concentration of 0.5 pm, within 13.2 s. Additionally, the selectivity of the device is investigated by measuring its response against a Cow‐like serum egg white protein (BSA), having a comparative molecular weight to that of the streptavidin. These results indicate a high sensitivity and rapid response of SnS2/h‐BN biosensor against the selective proteins, which can have significant implications in several fields including point‐of‐care diagnostics, drug discovery, and environmental monitoring.
Catalysis Sans Catalyst Loss: The Origins of Prolonged Stability of Graphene–Metal–Graphene Sandwich Architecture for Oxygen Reduction Reactions
Authors: Abdelhafiz Ali , Choi Ji Il , Zhao Bote , Cho Jinwon , Ding Yong , Soule Luke , Jang Seung Soon , Liu Meilin , Alamgir Faisal M. 
Published: October 2023

AbstractOver the past decades, the design of active catalysts has been the subject of intense research efforts. However, there has been significantly less deliberate emphasis on rationally designing a catalyst system with a prolonged stability. A major obstacle comes from the ambiguity behind how catalyst degrades. Several degradation mechanisms are proposed in literature, but with a lack of systematic studies, the causal relations between degradation and those proposed mechanisms remain ambiguous. Here, a systematic study of a catalyst system comprising of small particles and single atoms of Pt sandwiched between graphene layers, GR/Pt/GR, is studied to unravel the degradation mechanism of the studied electrocatalyst for oxygen reduction reaction(ORR). Catalyst suffers from atomic dissolution under ORR harsh acidic and oxidizing operation voltages. Single atoms trapped in point defects within the top graphene layer on their way hopping through toward the surface of GR/Pt/GR architecture. Trapping mechanism renders individual Pt atoms as single atom catalyst sites catalyzing ORR for thousands of cycles before washed away in the electrolyte. The GR/Pt/GR catalysts also compare favorably to state‐of‐the‐art commercial Pt/C catalysts and demonstrates a rational design of a hybrid nanoarchitecture with a prolonged stability for thousands of operation cycles.
Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2
Authors: Lázaro‐Gorines Rodrigo , Pérez Patricia , Heras‐Murillo Ignacio , Adán‐Barrientos Irene , Albericio Guillermo , Astorgano David , Flores Sara , Luczkowiak Joanna , Labiod Nuria , Harwood Seandean L. , Segura‐Tudela Alejandro , Rubio‐Pérez Laura , Nugraha Yudhi , Shang Xiaoran , Li Yuxing , Alfonso Carlos , Adipietro Kaylin A. , Abeyawardhane Dinendra L. , Navarro Rocío , Compte Marta , Yu Wenbo , MacKerell Alexander D. , Sanz Laura , Weber David J. , Blanco Francisco J. , Esteban Mariano , Pozharski Edwin , Godoy‐Ruiz Raquel , Muñoz Inés G. , Delgado Rafael , Sancho David , García‐Arriaza Juan , Álvarez‐Vallina Luis 
Published: October 2023

AbstractAdministration of neutralizing antibodies (nAbs) has proved to be effective by providing immediate protection against SARS‐CoV‐2. However, dual strategies combining virus neutralization and immune response stimulation to enhance specific cytotoxic T cell responses, such as dendritic cell (DC) cross‐priming, represent a promising field but have not yet been explored. Here, a broadly nAb, TNT, are first generated by grafting an anti‐RBD biparatopic tandem nanobody onto a trimerbody scaffold. Cryo‐EM data show that the TNT structure allows simultaneous binding to all six RBD epitopes, demonstrating a high‐avidity neutralizing interaction. Then, by C‐terminal fusion of an anti‐DNGR‐1 scFv to TNT, the bispecific trimerbody TNTDNGR‐1 is generated to target neutralized virions to type 1 conventional DCs (cDC1s) and promote T cell cross‐priming. Therapeutic administration of TNTDNGR‐1, but not TNT, protects K18‐hACE2 mice from a lethal SARS‐CoV‐2 infection, boosting virus‐specific humoral responses and CD8+ T cell responses. These results further strengthen the central role of interactions with immune cells in the virus‐neutralizing antibody activity and demonstrate the therapeutic potential of the Fc‐free strategy that can be used advantageously to provide both immediate and long‐term protection against SARS‐CoV‐2 and other viral infections.
Detection of Ice Formation With the Polymeric Mixed Ionic‐Electronic Conductor PEDOT: PSS for Aeronautics
Authors: Dongo Patrice D. , Hakansson Anna , Stoeckel Marc‐Antoine , Pavlopoulou Eleni , Wang Suhao , Farina Dario , Queeckers Patrick , Fabiano Simone , Iorio Carlo Saverio , Crispin Reverant 
Published: October 2023

AbstractIce formation detection is important in telecommunications and aeronautics, e.g., ice on the wings of an aircraft affects its aerodynamic performance and leads to fatal accidents. While many types of sensors exist, resistive sensors for ice detection have been poorly explored. They are however attractive because of their simplicity and the possibility to install an array of sensors on large areas to map the ice formation on wings. Hygroscopic ionic conductors have been demonstrated for resistive ice sensing but their high resistance prevents the readout of sensor arrays. In this work, mixed ionic‐electronic polymer conductors (MIEC) are considered for the first time for ice detection. The polymer blend poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) is solution deposited on a pair of electrodes. The sensor displays an abrupt rise in electrical resistance during the transition phase between water liquid to solid. It is proposed that the morphology and electronic transport in PEDOT are affected by the freezing event because the absorbed water in the PSS‐rich phase undergoes dilatation upon forming ice crystals. For the aeronautics application, successful tests of integration of sensing layer in pre‐preg layers of aeronautical grade and freezing detection are carried out to validate the ice detection principle.
Assessing clethodim spot spraying applications for control of problematic weedy rice and other grasses in California rice fields
Authors: Unan Rasim , Galvin Liberty , Becerra‐Alvarez Aaron , Al‐Khatib Kassim 
Published: October 2023

AbstractSpot spraying applications offer the opportunity to target specific weeds in a field, while simultaneously reducing herbicide usage and increasing the long‐term efficacy of chemical control options. The study is focused on controlling California weedy rice accessions (Oryza spp.) and problematic grass weeds with a spot spray application of clethodim in a flooded rice system. The efficacy of incorporating nonionic surfactant to clethodim applications was also assessed. Dose‐response experiments were carried out in a greenhouse on five weedy rice accessions, common grass rice weeds, and cultivated rice varieties L207, M105, M206, M209, M211, and S102 to determine the dose needed to affect these populations. Clethodim was applied in a field setting to assess spot spraying efficacy, the possibility of herbicide dispersion in the water, and crop injury. Clethodim successfully controlled weedy rice and grasses in the greenhouse. The effective rates to control 90% of the five test populations (ED90) were between 51 and 74 g ai ha−1 clethodim for weedy rice accessions. Adding nonionic surfactant to clethodim increased its efficacy by 1.6‐ to 1.9‐fold. Cultivated rice varieties did not exhibit any tolerance to clethodim, however, spot spraying applications at 150 g ai ha−1 clethodim did not cause any dispersion in the field. Clethodim spot spray application was effective both at the three‐ to four‐leaf growth stage and tillering growth stage for weedy rice.
Multinational enterprises and local firms’ export market entry: A panel data analysis of Vietnam's food processing industry
Authors: Nguyen Dao T. H. , Kokko Ari , Nguyen Thong T. 
Published: October 2023

AbstractThis study develops new insights into the spillover effects of foreign multinational enterprises (MNEs) on local firms’ export market entry, using the case of Vietnam—a notable global manufacturing hub located in Southeast Asia. The empirical analysis is based on a disaggregated firm‐level panel dataset of 25,032 observations of Vietnamese food processing firms during the period 2011–2016. The food processing industry is an essential part of the country's thriving manufacturing sector, with enormous potential for exports. The random‐effects Probit estimation results suggest that the presence of foreign MNEs significantly raises the likelihood that private local firms become exporters and thereby start integrating into global value chains. Further regressions reveal that foreign presence is also linked to higher export intensity among domestic firms, and that the magnitude of the estimated spillover effects is conditional on the specific measures of foreign MNE presence, the ownership structure in local industry, and the size of local firms. The findings highlight the considerable potential for foreign MNEs to influence local firms’ export prospects and validate the policy efforts to attract foreign direct investment inflows to the examined industry.
Systematic review of errors on beta‐2 transferrin gel electrophoresis testing of rhinorrhea and otorrhea
Authors: Eide Jacob G. , Mason William , Ray Amrita , Carey John , Cook Bernard , Craig John R. 
Published: October 2023

AbstractBackgroundBeta‐2 transferrin (B2‐Tf) gel electrophoresis (GE) is the preferred non‐invasive diagnostic modality for confirming cerebrospinal fluid (CSF) in body fluids. While B2‐Tf GE testing is highly sensitive and specific for CSF, false‐positive (FP) and false‐negative (FN) results can lead to diagnostic and therapeutic dilemmas. Several series have demonstrated potential causes of false B2‐Tf GE results, but few studies have reported reasons for these errors. The purpose of this systematic review was to describe sources of B2‐Tf GE errors.MethodsA systematic review was performed by searching OVID, EMBASE, and Web of Science databases for B2‐Tf GE studies. After applying exclusion criteria, original research studies directly addressing erroneous B2‐Tf GE results underwent qualitative analysis.ResultsOf the 243 abstracts screened, 71 underwent full‐text review and 18 studies reporting B2‐Tf GE errors were included for analysis. There were 15 potential FPs, 12 actual FPs, 12 potential FNs, 19 actual FNs, and 14 indeterminate results. There were also 246 potentially indeterminate results from in vitro studies. Reasons for B2‐Tf GE errors included serum transferrin alterations (n = 17; all potential), infection related (n = 13; 9 potential), orbital or salivary contamination (n = 2; 1 potential), and collection related (n = 255; 246 potential). There were 31 false or indeterminate results with unspecified reasons. There were no reported errors due to laboratory processing.ConclusionsMultiple potential or actual reasons for false or indeterminate results have been reported for B2‐Tf GE testing of rhinorrhea and otorrhea. Future studies should explore reasons for B2‐Tf testing errors and how these may affect clinical decision making.
Comparative study on the tribological properties of poly(arylene ether nitrile)/polytetrafluoroethylene composites: The influence of filler size and testing conditions
Authors: Ding Weiyi , Peng Xionghou , Li Jixiang , Heng Zhengguang , Zhou Shengtai , Zou Huawei 
Published: October 2023

AbstractIn this work, the influence of polytetrafluoroethylene (PTFE) filler size and testing conditions (i.e., air, water, and lubricating oil) on the tribological properties of poly(arylene ether nitrile) (PEN) was systematically investigated. The results showed that the addition of PTFE was beneficial to improve the tribological properties of PEN‐based composites which was related to the easier formation of transfer film on the surface of friction pair. Samples which were tested in water demonstrated a relatively higher friction coefficient (μ) and wear loss when compared with those tested in dry air and lubricating oil scenarios, which was attributed to the fact that friction induced heat and wear debris could be timely removed by water. In addition, the infiltration of water further reduced the interaction between PTFE filler and PEN, which aggravated the wear loss of sample blocks. When tested in lubricating oil, pure PEN showed the lowest wear loss when compared with that of PEN/PTFE composites. At a given content (20 wt%) of PTFE fillers, PEN/PTFE1.5μm exhibited the lowest μ in lubricating oil whereas PEN/PTFE5μm demonstrated the lowest specific wear loss in air condition (1.18 × 10−6 mm3/N·m). This work provided some useful information for the design and application of PTFE‐containing polymer composites that can be targeted in different lubrication scenarios in industrial fields.
Environmental drivers of yellowtail kingfish, Seriola lalandi, activity inferred through a continental acoustic tracking network
Authors: Clarke Thomas M. , Whitmarsh Sasha K. , Jaine Fabrice R. A. , Taylor Matt D. , Brodie Stephanie , Payne Nicholas L. , Butcher Paul A. , Broadhurst Matt K. , Davey Joshua , Huveneers Charlie 
Published: October 2023

Abstract

Identifying the species response to changing environments can contribute towards proactive and adaptable resource management and, although obtaining observations can be logistically challenging for aquatic species, can be postulated through monitoring.
A network of acoustic tracking receivers (n = 93) across south‐eastern Australia was used to identify the effects of environmental conditions on the activity of the yellowtail kingfish (Seriola lalandi, n = 63), an economically important species with a crucial role in pelagic ecosystems. Activity (measured via tri‐axial acceleration) provides an insight into the energetic expenditure of animals, which is linked to movement, behaviour, and physiological processes.
Kingfish activity was strongly influenced by sea surface temperature and hour of day, with smaller effects from distance to nearest landmass and bathymetry. Activity also decreased during higher tides and periods of greater moon fraction. Findings show that the energetic responses of kingfish are sensitive to long‐ and short‐term changes, which can regulate behaviours and physiological processes. Changes in kingfish activity and movement (residency and space use) were further investigated at a seasonal aggregation in a small temperate estuary (approx. 120 km2; Coffin Bay, South Australia), where individuals remained during the austral spring and summer (September–April), with a complete exodus in winter. Fifty per cent of tagged fish returned to this estuary in three consecutive years, indicating its importance for aggregating kingfish.
While residing in Coffin Bay, kingfish activity varied between interconnected areas, with temperature, hour of day, tide height, and moon fraction again identified as important explanatory variables. These findings have implications for the energetic budgets of large pelagic fish in subtropical and temperate regions, which are facing rapidly changing climates.
These results are important for understanding and accounting for the potential responses and physiological impacts of future climatic conditions on migratory pelagic species.
Impatience for information: Curiosity is here today, gone tomorrow
Authors: Molnar Andras , Golman Russell 
Published: October 2023

AbstractBased on the curiosity‐as‐drive theory and the theory of information gaps, we argue that curiosity—that is, the desire to seek out novel information for its own sake—is highly transient, and while people may be tempted by immediate answers, they may be less motivated when they need to wait for information. Contrary to standard economic models, we predict an immediacy effect (or present bias) for information even in those cases when waiting does not affect the objective value of information. Furthermore, we argue that this immediacy effect is independent from motivated emotion‐management; that is, introducing delays makes people less willing to obtain information for its own sake even when information does not elicit strong anticipatory feelings. We test these hypotheses in two pre‐registered experiments (N = 2406) featuring real effort and monetary incentives and find that introducing a delay in information provision significantly reduces participants' willingness to obtain information. In Study 1, we also show that people display a stronger immediacy effect for information than for monetary rewards. In Study 2, we demonstrate that people are impatient for information regardless of how they expect to feel after receiving the information, and even when the perceived instrumental value of information remains unaffected by the delay. The strong impatience for information in both studies is consistent with the notion that curiosity acts as a drive, and as such, is highly transient.