bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of the efficacy and safety of Ginkgolide Meglumine Injection combined with Butylphthalide in the treatment of Acute Ischemic Stroke
Authors: Xin-Shuai Li , Zhou Jia-Qi , Chen Xiang-Fan , Chen Xia , Feng Pan-Feng 
Published: January 2024

Objective
To evaluate the efficacy and safety of Ginkgolide Meglumine Injection (GMI) combined with Butylphthalide in the treatment of Acute Ischemic Stroke (AIS), and provide reference for rational clinical medication.

Methods
PubMed, Embase, Web of science, CNKI, Wanfang, VIP and other databases were searched for published studies on the treatment of AIS with GMI combined with Butylphthalide in both Chinese and English. The search period was from the establishment of the database to July 2023. The included studies that met the inclusion criteria were analyzed using RevMan 5.3 software for Meta-analysis.

Results
A total of 25 studies involving 2362 patients (experimental group = 1182, control group = 1180) were included. The results of meta-analysis showed that the overall effective rate of the experimental group was significantly higher than that of the control group [RR = 1.21, 95% CI (1.16, 1.26), P< 0.00001]. In addition, compared with the control group, the experimental group showed significant improvement in NIHSS score [SMD = -1.59, % CI (-2.00–1.18), P< 0.00001] and ADL score [SMD = 2.12, 95% CI (1.52, -2.72), P<0.00001], significant decrease in CRP [SMD = -2.24, 95% CI (-3.31, -1.18), P<0.0001] and TNF-α [SMD = -2.74, 95% CI (-4.45, -1.03), P< 0.005] levels, and improvement in plasma viscosity [SMD = -0.86, 95% CI (-1.07, -0.66), P< 0.00001]. However, the influence on homocysteine level remains inconclusive. Furthermore, there was no significant difference in the incidence of adverse reactions between the two groups [SMD = 0.95, 95% CI (0.71, 1.28), P> 0.05].

Conclusion
GMI combined with Butylphthalide shows good clinical application effects and good safety in the treatment of AIS. However, more large-sample, multicenter, randomized controlled are needed to confirm these findings.
Quantitative changes in the corneal endothelium and central corneal thickness during anterior chamber inflammation: A systematic review and meta-analysis
Authors: Mejía-Salgado Germán , Muñoz-Vargas Paula Tatiana , Cifuentes-González Carlos , Flórez-Esparza Gabriela , Paquentín-Jiménez Rebeca , Castro-Monreal Miguel Ángel , Medina-Galindo Naomi , Hernández-Herrera Gilma Norella , Concha-del-Río Luz Elena , de-la-Torre Alejandra 
Published: January 2024

Purpose
To establish the effects of anterior chamber inflammation (ACI) on the corneal endothelium parameters and central corneal thickness (CCT).

Methods
We conducted a comprehensive literature review using medical databases (PubMed, EMBASE, VHL, and medRxiv) on March 8, 2023, for studies that included patients with ACI who had undergone specular microscopy or pachymetry. Case series with >10 patients, cross-sectional, case-control, and cohort studies were included. The risk of bias was assessed using CLARITY tools and validated scales such as those by Hassan Murad et al. and Hoy et al. A narrative synthesis and a quantitative standardized mean difference meta-analysis, I2 heterogeneity assessment, and publication bias tests were conducted. The study was registered in PROSPERO (CRD42023420148) and approved by the Universidad del Rosario ethical committee (DVO005 2277- CV1712).

Results
Thirty-four studies, encompassing 1,388 eyes with ACI, were included. Compared with healthy controls, overall, ACI eyes show significant mean differences in endothelial parameters (endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX)) (P < 0.05). In the subgroup analysis compared with healthy controls, both active and chronic-recurrent ACI demonstrated a reduced ECD. An increased CV was observed in active, inactive, and chronic-recurrent ACI. Lower HEX was evident in inactive, acute, and chronic-recurrent ACI, while both active and acute ACI exhibited high CCT.

Conclusion
ACI leads to significant alterations in endothelial parameters and CCT. The primary contributors to these changes are increased IOP, uveitis duration, and intraocular surgeries. Further studies are needed to explore the impact of ACI etiology on the endothelium, potential biases in IOP measurements during acute ACI episodes, and the potential necessity for monitoring the endothelial parameters and CCT in patients with chronic ACI.
Capillary Microhematocrit Measurement as a Screening Test for Anemia in Children
Authors: Mustaring Mustaring , Tranggana Sunar , Daud Dasril 
Published: January 2024

The spectrophotometric measurement of hemoglobin performed with a well standardized instrument using venous blood is widely accepted as a reference standard for anemia. In developed countries automated electronic counters are used instead However, this method of determining anemia is not practical for screening in developing countries as it requires special skill or expensive equipment to obtain the specimen or to perform the test.
The primary objective of this study was to determine the feasitnlity of ustng capillary nucrohematoerit measurement as a screening test for anemia.
The 104 patients examined ranged in age from 6 months to 6 years; 65 were males and 36 females Sixty one of the 104 cases (58.7%) were below 2 years of age and the other 43 cases (41.5%) were older than 2 years Hemoglobin values ranged from 2.7-13.5 g/dl and capillary microhematocrit ranged from 9-41%. Analysis of the result showed a significant correlation between the capillary microhematocrit values and the capillary hemoglobin values (r = 0.99 and p < 0.001) The sensitivity of the microhematocrit method for detecting anemia was 91.11% and the spectficity was 89.83%. The predictive value for a normal (negative) microhematocrit was 92.98% and the predictive value for a low (positive) microhematocrit was 87.23%.
We conclude from this study that the capillary microhematocrit measurement method can be appropriately used as a screening test for anemia.
Iron role paradox in nerve degeneration and regeneration
Authors: Bolandghamat Samira , Behnam‐Rassouli Morteza 
Published: January 2024

AbstractIron accumulates in the neural tissue during peripheral nerve degeneration. Some studies have already been suggested that iron facilitates Wallerian degeneration (WD) events such as Schwann cell de‐differentiation. On the other hand, intracellular iron levels remain elevated during nerve regeneration and gradually decrease. Iron enhances Schwann cell differentiation and axonal outgrowth. Therefore, there seems to be a paradox in the role of iron during nerve degeneration and regeneration. We explain this contradiction by suggesting that the increase in intracellular iron concentration during peripheral nerve degeneration is likely to prepare neural cells for the initiation of regeneration. Changes in iron levels are the result of changes in the expression of iron homeostasis proteins. In this review, we will first discuss the changes in the iron/iron homeostasis protein levels during peripheral nerve degeneration and regeneration and then explain how iron is related to nerve regeneration. This data may help better understand the mechanisms of peripheral nerve repair and find a solution to prevent or slow the progression of peripheral neuropathies.
Quasi-Optimality of an AFEM for General Second Order Elliptic PDE
Authors: Pal Arnab , Gudi Thirupathi 
Published: January 2024

Abstract
In this article, convergence and quasi-optimal rate of convergence of an adaptive finite element method (in short, AFEM) is shown for a general second-order non-selfadjoint elliptic PDE with convection term

b
∈

[

L
∞

⁢

(
Ω
)

]

d

{b\in[L^{\infty}(\Omega)]^{d}}

and using minimal regularity of the dual problem, i.e., the solution of the dual problem has only

H
1

{H^{1}}

-regularity, which extends the result [J. M. Cascon, C. Kreuzer, R. H. Nochetto and K. G. Siebert,
Quasi-optimal convergence rate for an adaptive finite element method,
SIAM J. Numer. Anal. 46 2008, 5, 2524–2550]. The theoretical results are illustrated by numerical experiments.
Use of saliva-based qPCR diagnostics for the accurate, rapid, and inexpensive detection of strep throat
Authors: Peachey Madeline H. , Kubow Kristopher E. , Blyer Kristina B. , Halterman Julia A. 
Published: January 2024

Abstract

Objectives
Outpatient health care facilities are essential for quickly diagnosing common infectious diseases such as bacterial and viral pharyngitis. The only form of pharyngitis requiring antibiotics is strep throat (ST); however, antibiotic prescription rates are much higher than ST prevalence, suggesting antibiotics are being inappropriately prescribed. Current rapid ST diagnostics may be contributing to this problem due to the low sensitivity and variable specificity of these tests. It is best practice to verify a negative ST diagnosis with a group A Streptococcus (GAS) culture, but many clinics do not perform this test due to the additional cost and 24–72 h required to obtain results. This indicates there is great need for more accurate rapid diagnostic tools in outpatient facilities. We hypothesized that next generation qPCR technology could be adapted to detect GAS DNA from saliva samples (instead of the traditional throat swab) by creating a simple, fast, and inexpensive protocol.

Methods
Saliva specimens collected from patients at James Madison University Health Center were used to test the effectiveness of our Chelex 100-based rapid DNA extraction method, followed by a fast protocol developed for the Open qPCR machine to accurately detect ST.

Results
Our final saliva processing and qPCR protocol required no specialized training to perform and was able to detect ST with 100 % sensitivity and 100 % specificity (n=102) in 22–26 min, costing only $1.12 per sample.

Conclusions
Saliva can be rapidly analyzed via qPCR for the accurate and inexpensive detection of ST.
Erosion rate of AA6082-T6 aluminum alloy subjected to erosive wear determined by the meta-heuristic (SCA) based ANFIS method
Authors: Yılmaz Serhat , Yıldırım Aygen Ahsen , Feyzullahoğlu Erol 
Published: January 2024

Abstract
AA6082-T6 aluminum alloy is used in different engineering applications. The erosive wear takes places in many machine parts. The prediction of wear amounts for aluminum alloy materials is complicated and nonlinear phenomena. The fuzzy inference systems (FIS) and the artificial neural networks (ANNs) have a series of properties on modeling nonlinear systems. In this study, it was aimed to determine the optimum erosive wear parameters in terms of wear resistance. This study suggests a meta-heuristic (sine–cosine algorithm-SCA) Based ANFIS prediction model for prediction of wear behavior of AA6082-T6 aluminum alloy within various impingement pressure, impact velocity, impingement angle and particle sizes. In this study, a model is developed that determines the optimum erosive wear parameters to achieve the minimum wear rate. The erosion rate-SCA Based ANFIS prediction model extracted reasonable results. Estimation capability has been achieved to 99.81 % by the proposed model.
Language ideologies and the use of French in an English-dominant context of Canada: new insights into linguistic insecurity
Authors: Bouchard Marie-Eve 
Published: January 2024

AbstractTeachers play an essential role in fostering linguistic security in their classrooms. The aim of this study is to identify the language ideologies articulated by teachers in the Francophone schools of the English-dominant context of British Columbia (Canada) in order to explore how the different practices they implement to foster the use of French in their multilingual classrooms and foster linguistic security may interact and expose contradictions. The findings are based on a thematic analysis of interviews with twenty-one French-speaking high school teachers. I argue that linguistic ideologies provide a useful locus for studying the tensions produced by institutional policies and practices and the possible impact on the students’ feelings of linguistic insecurity. Building on excerpts from the interviews, the findings indicate that the practices the teachers use to implement the French-language policy in their classrooms must be examined further as they might be harming the efforts they are making to increase linguistic security. This paper is intended to contribute to the ongoing conversation about the practical process of engaging with linguistic insecurity.
Sorption behavior of cesium ions to Mg-containing calcium silicate hydrate in a co-precipitation process
Authors: Seki Tsugumi , Oasa Ryota , Chida Taiji , Niibori Yuichi 
Published: January 2024

AbstractThe sorption behavior of Cs to Mg-containing calcium silicate hydrate (C–S–H) was examined to consider C–S–H formation under the water-saturated conditions around a radioactive waste repository. The amount of Cs sorption was slightly lower for Mg-containing C–S–H than for C–S–H, because Mg leads to a decrease in sorption sites by facilitating the polymerization of silicate chains. However, the apparent sorption distribution coefficient Kd of Cs on C–S–H with a Ca/Si molar ratio of 0.8 and Mg contents up to 20% was estimated to be 3.4–6.1 mL/g. Furthermore, the amount of Cs sorption was not decreased by the presence of Ba. The apparent Kd obtained in this study was about 10 times higher than that conventionally estimated for host rocks in the plutonic repository, indicating that C–S–H retains the effect of Cs immobilization even when it contains Mg.
Graphical abstract
Spór o status ludzkiego embrionu w kontekście rozważań na temat in vitro
Authors: Franczak Wiktoria 
Published: January 2024

W artykule wskazano główne kontrowersje, związane z pojęciem embrionu. Wiążą się one ze starciem dwóch koncepcji bioetycznych: świętości życia i nowej etyki jakości życia. Postęp biotechnologiczny w zakresie medycyny stwarza różnorodne możliwości ingerencji lekarzy już w początkowej, embrionalnej fazie życia ludzkiego. Stwarza to wiele dylematów natury moralnoprawnej, stając się przedmiotem sporów w dyskusjach doktrynalnych. Z perspektywy artykułu istotny był problem zdefiniowania istoty człowieczeństwa, w tym również pojęcia „embrion ludzki” - z uwzględnieniem dominujących ujęć: liberalnego (świeckiego) i religijnego (chrześcijańskiego). Kluczowa okazała się więc odpowiedź na pytanie: kim jest człowiek oraz od którego momentu zaczyna się osoba ludzka? Czy embrion jest podmiotem, czy też przedmiotem prawa? Przywołano sposoby definiowania terminu „osoba” w różnych, międzynarodowych aktach prawnych, orzecznictwie i literaturze przedmiotu. Omówiono główne teorie statusu embrionu ludzkiego: koncepcję, na gruncie której embrion traktowany jest jak rzecz, koncepcję przyznającą embrionowi status osoby, oraz koncepcję pośrednią, tzw. „godnościową”. Przedstawiono różne prawne modele ochrony życia ludzkiego Przedmiotem rozważań stało się również zagadnienie zapłodnienia pozaustrojowego in vitro implikowane przyjętym w danym państwie prawnym modelem ochrony życia w jego początkowej (prenatalnej) fazie.
ОСОБЛИВОСТІ ОБ'ЄКТІВ АВТОМАТИЧНИХ СИСТЕМ КООРДИНУВАЛЬНОГО УПРАВЛІННЯ
Authors: Дубна С. М. , Гурський О. О. , Гончаренко О. Є. 
Published: January 2024

Представлені особливості об'єктів управління в яких доцільно координувати регульовані змінні в перехідних режимах. Розглянуті відповідні приклади об'єктів та зазначені їх загальні характеристики. Виділений клас об'єктів управління для яких варто синтезувати системи управління, що забезпечують узгодження перехідних процесів.
Метою роботи є підвищення ефективності функціонування певного класу об'єктів управління шляхом застосування систем, що забезпечують координацію регульованих змінних у перехідних режимах. Для досягнення поставленої мети було вирішено задачу пов'язану з виділенням класу об'єктів управління і їх загальних характеристик та особливостей для доцільного застосування алгоритмів координувального управління. Було показано, що ефективність функціонування та ККД деяких об’єктів залежіть від співвідношення регульованих змінних. В якості прикладів указано на співвідношення паливо-повітря у парогенераторах та котельних установках, або співвідношення між швидкістю обертання валу турбокомпресора і кутом установки лопаток вхідного направляючого апарату. Також показані різні структурні схеми об’єктів управління для можливої композиції цих схем у загальну структурну схему автоматичної системи координувального управління.
У результаті проведених досліджень, у процесі виконання поставленої задачі, було визначено загальну структурну схему об'єкта координувального управління та загальні його характеристики. Такі загальні характеристики були визначені на основі розглянутих прикладів об’єктів управління в яких важливо дотримувати деякі співвідношення між регульованими змінними. В якості прикладів було розглянуто: парогенератор з типовою системою регулювання, газотурбінний та реактивний двигун, холодильну установку з відцентровим компресором. Показано особливості ефективного функціонування розглянутих об'єктів з огляду на аналіз їх загальних характеристик.
Analisis Manajemen Risiko SPBE Menggunakan COBIT 5 For Risk dan ISO 31000:2018 di Kabupaten Magetan ( E-Government Risk Management Analysis Using COBIT 5 For Risk and ISO 31000:2018 in Magetan Regency)
Authors: Aprianto Khrisna , Endroyono Endroyono , Nugroho Supeno Mardi Susiki 
Published: January 2024

Kondisi penerapan SPBE di Indonesia saat ini mengalami beberapa hambatan. Diantaranya yaitu, lebih dari 50% anggaran instansi pemerintah dibelanjakan untuk pengadaan perangkat lunak sejenis.Penggunaan server dan pusat data masih di bawah 40% utilitasnya. Ego sektoral antar instansi pemerintah menjadi salah satu sebab penerapan SPBE tidak optimal. Untuk itu, pemerintah melalui KemenPAN RI menerbitkan Peraturan Menteri Nomor 5 Tahun 2020 sebagai pedoman bagi instansi pemerintah dalam manajemen risiko SPBE. Organisasi XY di Kabupaten Magetan sebagai instansi pelaksana SPBE berkewajiban melakukan manajemen risiko untuk menjamin tercapainya sasaran dan tujuannya. Dalam penelitian ini, peneliti menggunakan COBIT 5 for risk dan ISO 31000:2018 untuk melakukan analisa terhadap manajemen risiko SPBE. Tujuan dari penelitian adalah analisa efektifitas manajemen risiko SPBE yang diterbitkan KemenPAN RI dengan COBIT 5 for risk dan ISO 31000:2018 dan menghasilkan rekomendasi manajemen risiko SPBE sebagai panduan penyusunan manajemen risiko SPBE. Dari hasil identifikasi diperoleh 21 risiko dan 15 rekomendasi pengendalian.
Pemanfaatan Sistem Informasi Desa (SID) untuk Mewujudkan Smart Village di Kalurahan Panggungharjo DIY (Utilization of Sistem Informasi Desa (SID) to Realize Smart Village in Kalurahan Panggungharjo, Sewon, Bantul, DI Yogyakarta)
Authors: Sulistyowati Fadjarini , Tyas Hari Saptaning , Dibyorini M.C. Candra Rusmala , Puspitosari Condrodewi 
Published: January 2024

Smart village merupakan desa yang secara inovatif mampu menggunakan teknologi informasi untuk mencapai peningkatan kualitas hidup, efisiensi dan daya saing dalam aspek ekonomi, sosial dan lingkungan tanpa meninggalkan kearifan lokal. Penelitian ini bertujuan untuk mendeskripsikan pemanfaatan SID dan menemukan faktor-faktor yang mewujudkan smart village di Kalurahan Panggungharjo. Penelitian ini menggunakan pendekatan fenomenologi. Teknik pengumpulan data menggunakan FGD, wawancara dan observasi. Analisis data menggunakan teknik analisis data interaktif. Hasil penelitian menunjukkan adanya faktor-faktor yang mendorong terwujudnya smart village dengan pemanfaatan SID, yakni: 1) Keberadaan SID yang diinisiasi desa dapat dimanfaatkan untuk melakukan pendataan desa yang lebih akurat dan sebagai media penyampaian informasi dan komunikasi; 2) Prakarsa pemerintah desa dalam mendorong pemanfaatan inovasi teknologi informasi dan partisipasi masyarakat dalam program pembangunan desa seperti pengolahan sampah dari rumah tangga dan pewarisan budaya lokal melalui lumbung kebudayaan; 3) SID mendorong relasi yang lebih baik antara pemerintah desa, masyarakat dan lingkungan untuk mendukung terwujudnya smart village;
Public Communication in The Era of The Communication and Information Technology Revolution
Authors: Hardianti Fitri , Fatmawati  , Pratiwi Yuli Rahmi 
Published: January 2024

Pemerintah Provinsi Riau melalui Diskominfotik Provinsi Riau beradaptasi menggunakan teknologi untuk kepentingan komunikasi publik. Tujuannya untuk mengetahui gambaran komunikasi publik yang dilakukan Diskominfotik Provinsi Riau di era revolusi teknologi komunikasi dan informasi. Metode yang digunakan adalah kualitatif, Teknik pengumpulan data yakni observasi, wawancara dan dokumentasi. Teknik analisis data menggunakan Miles dan Huberman serta Teknik Pemeriksaan keabsahan data menggunakan Triangulasi. Hasil penelitian menunjukkan Komunikasi publik yang dilakukan Diskominfotik Provinsi Riau melalui sejumlah tahapan. Tahapan pertama yakni mengumpulkan data dari berbagai sumber dengan membentuk kemitraan dengan sejumlah Operasi Perangkat Daerah (OPD), membentuk komunitas informasi masyarakat, bermitra dengan humas-humas vertikal dan ikut berperan aktif dalam organisasi Perhumas Riau. Selanjutnya tahap analisis data dan menyajikannya dalam sebuah konten yang nantinya disebarluaskan kepada masyarakat. Setelah konten tersebut siap, kemudian didistribusikan ke seluruh kanal media Pemerintah Provinsi Riau diantaranya Website mediacenter.riau.go.id, media sosial diantaranya Instagram, Facebook, Twitter dan Youtube, tidak lupa juga disiarkan di radio online
Kesenjangan Digital dan Solusi yang Diterapkan di Indonesia Selama Pandemi COVID-19
Authors: Jayanthi Ria , Dinaseviani Anggini 
Published: January 2024

The digital divide is a crucial issue in developing countries. Indonesia needs to find elite solutions to solve the issue. By looking at the speedy development of telecommunications and the cheapening of information technology, especially the internet, the expectation is to lower the digital gap problems. By this time, the digital divide discoursing is mostly associated with the availability of access and infrastructure, even though good digital capabilities are a prerequisite for digital equality. This study aims to observe how the conditions of the digital divide in Indonesia and the way to solve it presented by the government or individuals to overcome the digital divide. Using the descriptive qualitative method in this research is to illustrate the restrictions of the digital divide between provinces and regions in Indonesia and what solutions have been taken to address the digital divide in Indonesia. This study concludes that the enlargement of internet access in Indonesia has not been linear with the digital competency of its people. It includes motivation to be more productive using the internet, get useful information and use it for productive activities that can improve the economy.
Scapholunate Ligament Rupture and Coincident Fracture Proximal Pole Scaphoid Presenting Late with Osteonecrosis
Authors: S Vignesh , Prabhakar R Ponnaian , Shekhar Raj 
Published: January 2024

Case:
A 29-year-old young active man with ununited necrosed proximal fifth of scaphoid with chronic scapholunate ligament disruption was managed by excision of proximal pole fragment and interosseous scapholunate reconstruction using modified Brunelli triple ligament tenodesis technique with satisfying outcome at 6 months and return to sports instructor job by the end of 1 year.

Conclusion:
Meticulous understanding and algorithmic itemwise approach of injury components can lead to optimal management of complex unstable wrist injuries such as scapholunate dissociation. To the best of our knowledge, this is the first report on excision of proximal pole of scaphoid coupled with scapholunate ligament reconstruction.