bluuebunny/crossref_metadata_2025_split huggingface dataset:
El camino hacia la erradicación del cáncer de cuello uterino en América del Sur para 2030
Authors: Vega Crespo Bernardo José , Delgado López Dayanara Alejandra , Pozo Palacios Juan Carlos , Neira Molina Vivian Alejandra 
Published: February 2025

Introducción: en 2021, la Organización Mundial de la Salud (OMS) presentó la estrategia 90-70-90, orientada a la erradicación del cáncer cervical (CCU) para el año 2030. Esta iniciativa tiene como objetivo principal reducir tanto la incidencia como la mortalidad asociada a esta enfermedad, estableciendo una meta de menos de 4 casos por cada 100 000 mujeres.

Desarrollo: la citología cervical es la técnica más comúnmente utilizada para la detección del cáncer cervical. En los últimos cinco años, la cobertura promedio del tamizaje ha sido del 27,5 %. Entre los países de América del Sur, Guyana registra la cobertura más baja con un 16 %, mientras que Paraguay alcanza la más alta con un 84 %. La tasa bruta de incidencia de cáncer cervical en la región es de 25,7 por cada 100 000 mujeres, siendo Bolivia el país con la tasa más alta (34,1) y Uruguay el que presenta la más baja (15,2). Respecto a la mortalidad, la mediana en América del Sur es de 14,5 por cada 100 000 mujeres; Bolivia encabeza la lista con 19, mientras que Chile muestra la menor tasa con 8,5.
En contraste, países que avanzan hacia la eliminación del cáncer cervical, como Estados Unidos, Suiza y Australia, registran coberturas de tamizaje superiores al 84 % en el mismo período. Estas naciones reportan tasas de incidencia por debajo de 8,1 y tasas de mortalidad menores a 3,5 por cada 100 000 mujeres, lo que refleja el impacto de estrategias de prevención y detección más efectivas.

Conclusiones: A pesar de los esfuerzos, América del Sur aún enfrenta un desafío significativo para alcanzar los objetivos de eliminación del cáncer cervical. Las tasas de incidencia y mortalidad permanecen elevadas en comparación con los países más avanzados en esta meta. Es crucial que los gobiernos evalúen la relación costo-efectividad de los programas de tamizaje e incorporen métodos más sensibles y aceptados para la detección temprana. Además, es fundamental expandir las estrategias de vacunación contra el VPH, abarcando a jóvenes varones y mujeres hasta al menos los 26 años, con el fin de fortalecer la prevención a largo plazo.
Intervenção sobre o comportamento de masturbação pública de uma criança com Transtorno do Espectro Autista
Authors: Lobo-Carneiro Lorena De Oliveira , Britto Ilma A. Goulart de Souza 
Published: February 2025

Este trabalho teve como objetivo intervir para a redução de masturbação pública emitida por uma criança de cinco anos de idade com Transtorno do Espectro Autista (TEA) após avaliação funcional do comportamento. Foram conduzidas: (a) avaliação indireta; (b) avaliação direta; e (c) análise funcional (experimental) proposta por Iwata et al. (1982/1994) acrescida das subcondições atenção-reprimenda, atenção-instrução-e-bloqueio, sozinha-com-reforçador e sozinha-sem-reforçador. Os procedimentos foram controlados pelo delineamento de múltiplas condições. Os resultados apontaram que o comportamento de masturbação pública era mantido por reforçamento automático. Durante a intervenção, foram usados os procedimentos de Interrupção de Resposta e Redirecionamento (RIRD), no qual a resposta de masturbação era interrompida e redirecionada para uma resposta incompatível que era seguida por reforçamento (DRI). O RIRD foi associado ao Reforçamento Diferencial de Outros Comportamentos (DRO) de intervalo variável (15s) contingente a não emissão da resposta de masturbação. Para o controle experimental foi empregado o delineamento ABA seguido de follow-up. Os resultados apontaram que os procedimentos foram eficazes para a diminuição da resposta de masturbação pública em ambiente clínico. Este estudo contribuiu para demonstrar a aplicação de variáveis que controlam comportamentos desafiadores, para o direcionamento de intervenção e avançou ao utilizar a associação de procedimentos como o uso de reforçamento diferencial juntamente com a interrupção e o redirecionamento de respostas. Palavras-chave: Análise funcional, TEA, RIRD, Reforço diferencial, Masturbação pública.
Práticas pedagógicas no jardim sensorial
Authors: Silva Gabriela Lachmann , Cunha Gislaine Scarlat , Azevêdo Maria Anália Vieira , Guizoni Valquiria de Borba , Barroso Vanda Maria Vital , Brandt Andressa Graziele 
Published: February 2025

A construção de jardins sensoriais é idealizada a fim de estimular os cinco sentidos (visão, olfato, tato, audição e paladar) do corpo humano, por meio de plantas e materiais da natureza, gerando benefícios que vão do bem-estar ao uso do jardim como recurso pedagógico e interdisciplinar. No projeto de extensão jardim sensorial, objetivou-se construir um laboratório didático-pedagógico e educativo para utilizar a capacidade do paisagismo como ferramenta promotora de atividades de ensino e aprendizagens, por meio do contato com a natureza, inclusão social, sustentabilidade e promoção do bem-estar de forma interdisciplinar. Justifica-se, esse projeto como recurso pedagógico e interdisciplinar, pois o mesmo contempla as três dimensões ensino, pesquisa e extensão. Como resultados alcançados, destaca-se a utilização do mesmo como laboratório didático pedagógico para o ensino dos componentes curriculares dos cursos do IFC - Campus Camboriú e a realização de práticas pedagógicas com crianças e professores dos municípios da Associação dos Municípios da Foz do Rio Itajaí – AMFRI. A partir das atividades pedagógicas já realizadas, conclui-se que o jardim sensorial proporcionou, às crianças e aos professores, conhecimentos estéticos e sensoriais.

Palavras-chave: Programa de Educação Tutorial; Curso de gramática; Formação de professores.
Effect of Different Papain Concentrations on Yield and Quality of Tuna Eye Oil
Authors: Trilaksani Wini , Nurhayati Tati , Santoso Joko , Riyanto Bambang , Fauziah Silva , Sinulingga Fahri 
Published: February 2025

Graphical Abstract

Highlight Research

Innovative Use of By-Products: The study explores the use of tuna eye by-products, a rich source of docosahexaenoic acid (DHA), to reduce reliance on imported fish oil and promote sustainable utilization of fishery waste.
Enhanced Extraction Methodology: Enzymatic extraction using papain at optimal concentrations significantly improves the yield and quality of tuna eye oil, achieving up to six times higher yield compared to other methods.
Nutritional and Quality Benefits: The extracted oil demonstrated low Index of Atherogenicity (IA) and Index of Thrombogenicity (IT), indicating its potential as a heart-healthy dietary supplement, with DHA and EPA concentrations well preserved.
Environmental and Safety Advantages: The enzymatic process is solvent-free, minimizing environmental impact and ensuring consumer safety, while also addressing challenges posed by extended sample storage during the COVID-19 pandemic.

Abstract
Docosahexaenoic acid (DHA) is an essential omega-3 fatty acid, a major component of the human frontal cortex performing a significant role in the fetal brain and retinal development. Deficiency of this component, especially in fetuses, infants, and young children, triggers poor brain neurodevelopment and cognitive impairment. Compulsion of fish oil rich in DHA fulfilled by imports reaching 9,124,579 kg in 2021. In the interim, utilization of potential by-products (tuna’s eyes) as a source of DHA has not been piloted on account of some constraints, one of which is yield that has not been maximized. Enzymatic oil extraction is considered green extraction which is safer and produces higher yields than conventional extraction using high temperatures and chemical solvents. The purpose of this study was to determine the optimal concentration of papain in enzymatic extraction to obtain the highest possible yield of tuna eye oil and the quality of extracted tuna eye oil. The best results were obtained from the extraction with papain enzyme 1% at 55°C for 1 hour, giving an optimal yield. The best yield produced was 8.59 ± 0.69%, or six times higher than cold extraction (centrifugation) without enzyme addition (1.41 ± 0.07%). Adding enzyme concentration up to 1% resulted in increased yield, decreased dark color, decreased viscosity, and improved oxidation quality. The study found that the Index of Atherogenicity (IA) and Index of Thrombogenicity (IT) values fell within low ranges 0.38-0.40 and 0.20-0.21, respectively. Heating during the enzymatic hydrolysis process (55°C) for 1 hour did not significantly alter the percentage of PUFA, and especially DHA remained well preserved.
Does Resident Gender or Race/Ethnicity Affect Orthopaedic Surgery Case Volume During Residency Training?
Authors: Shoga Parisun , Van Heest Ann , Ames S. Elizabeth , Hogan Sean O. , Holmboe Eric , Klingensmith Mary , Park Yoon Soo , Parker Corey , Solberg Erik , Templeton Kimberly 
Published: February 2025

Introduction:
Disparities in case volumes have been reported in some surgical specialties. The objective of this study was to evaluate whether gender or racial/ethnicity disparities exist during orthopaedic surgery residency surgical case log volume.

Methods:
Accreditation Council for Graduate Medical Education Case Log Database for orthopaedic surgery residents for 9 years of cohorts graduating in academic years 2013-2014 to 2021-2022 were analyzed to compare case logs between men and women, as well as race/ethnicity, defined by Association of American Medical Colleges as underrepresented in medicine (URiM) and non-URiM groups.

Results:
Longitudinal analyses of total required minimum type cases indicate significant gender differences among the initial graduating cohorts with women trainees reporting 33 cases fewer than men; in the most recent years of this study period, women trainees reported 5 cases fewer than men per year. URiM trainees reported 29 cases fewer at baseline, while in the most recent years, there were no significant differences. Significant differences exist for 8 of the 15 case minimum types with fewer women cases at baseline; in the most recent years, women had fewer cases in anterior cruciate ligament Reconstruction, Ankle Fracture Fixation, Closed Reduction Forearm Fracture, Total Hip Arthroplasty, and Total Knee Arthroplasty. There were significant differences for 3 of 15 case minimum types at baseline for URiM trainees with no significant differences in most recent years. Hand was the only anatomic area with women reporting significantly more cases than men, both initially and over the 9 years of study period.

Conclusion:
Significant differences exist in case volume and case types during orthopaedic surgery residency based on gender for the initial cohort, albeit lessening in most recent years. Although initial differences in cases volumes based on race/ethnicity exist, no significant differences persist in most recent years of the study period.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
Modification and Performance Evaluation of Radio Frequency Identification Technology in High-Temperature and High-Pressure Environments
Authors: Zhang Jian , Yu Peihang , Zhou Zhaoming , Li Hui , Zhou Ting , Yu Chunlei 
Published: February 2025

Summary
As oil and gas exploration progresses into deeper and ultradeep territories, the radio frequency identification (RFID) tags used in drillpipes are required to demonstrate enhanced resilience to elevated temperatures and pressures. Current research on tags for ultrahigh temperature and ultrahigh pressure environments is relatively scarce. This study focuses on the application of RFID in deeper drilling operations, aiming to further enhance the tags’ temperature and pressure resistance to meet the application requirements. Numerical simulations were conducted to assess the mechanical properties of RFID tags installed on drillpipes of varying dimensions under conditions of elevated temperatures and pressures. This process enabled the optimization of the dimensions of the RFID tags and installation holes. The optimal dimensions for the RFID tag were determined to be φ24.3×7 mm, with the corresponding installation hole being φ24.3×11 mm. To evaluate the high-temperature endurance of the RFID tags, they were subjected to a temperature of 200℃ for a period of time, after which a maximum temperature of 230℃ was applied. Furthermore, a bespoke high-temperature and high-pressure apparatus was used to conduct a 7-day endurance test at 200℃ and 200 MPa. The findings demonstrated that the RFID tags exhibited reliable performance even when subjected to an extreme temperature of 230℃. Furthermore, the RFID tags exhibited consistent performance when subjected to prolonged periods of high temperature and pressure. The efficacy of the RFID tags was further validated through an 11-well field experiment, wherein the embedded tags exhibited no indications of detachment or deterioration. Once removed from the apparatus, the tags were able to be read automatically in real time, thus enabling the automated collection of data from the drillpipe in actual operating conditions. The findings of this study provide valuable insights and establish a foundation for the design and application of RFID tags in the challenging environments of deep and ultradeep oil and gas exploration.
Effects of biofertilizers and nano iron-silicon oxide on yield, dry matter remobilization, and trend of changes of the grain filling of triticale under salinity stress
Authors: Aghaei Fatemeh , SeyedSharifi Raouf , Farzaneh Salim , Narimani Hamed 
Published: February 2025

Abstract

Salinity is the major abiotic stress factor negatively affecting numerous crop plants’ morphological and biochemical traits, resulting in reduced agricultural production and sustainability. Iron-silicon (Fe-Si) nanoparticles (NPs) and plant growth-promoting rhizobacteria can decrease abiotic stress and improve crop yield. Accordingly, a factorial experiment was conducted in 2021 under greenhouse conditions using a randomized complete block design with three replicates. The treatment included salinity at three levels (no salinity, 35 mM and 70 mM with sodium chloride), four levels of NP foliar application (foliar application with water as control, nano Si, nano Fe, and Fe-Si NPs), and four levels of plant growth-promoting rhizobacteria (PGPR; no application, Pseudomonas, Azospirillum, and Azospirillum and Pseudomonas applications). According to the results, the highest dry matter remobilization from shoot and stem and the contribution of stem reserves to the grain yield were found in severe salinity stress conditions. In addition, under 70 mM salinity stress conditions, PGPR and nano Fe-SiO applications increased carotenoid content (51.1%), leaf area index (39.4%), total Chl (31.4%), chlorophyll a (29.1%), grain-filling duration (22.2%), effective grain-filling duration (EGFD, 16.3%), and grain yield (12.8%) when compared to control (no PGPR and NP applications) at the same level of salinity. According to the findings, the application of PGPR and NPs increased the grain yield of triticale in salinity stress conditions because of improving the components of grain filling and some physiological features.
Soil bacterial diversity and community structure of cotton rhizosphere under mulched drip- irrigation in arid and semi-arid regions of Northwest China
Authors: Zhang Man , Hu Yang , Ma Yue , Hou Tianyu , Wang Juanhong , Che Qingxuan , Chen Bolang , Wang Qinghui , Feng Gu 
Published: February 2025

Abstract

Background
Xinjiang is situated in an arid and semi-arid region, where abundant heat and sunlight create highly favorable conditions for cotton cultivation. Xinjiang's cotton output accounts for nearly one-quarter of global production. Moreover, the implementation of advanced planting techniques, such as 'dwarfing, high-density, early-maturing' strategies combined with mulched drip irrigation, ensures stable and high yields in this region. Despite these advancements, limited research has focused on the microbial mechanisms in cotton fields employing these advanced planting methods.
Results
The bacterial and phoD communities in the cotton rhizosphere were predominantly composed of nine bacterial phyla (i.e., Proteobacteria, Actinobacteria, Acidobacteria, Gemmatimonadetes, Chloroflexi, Bacteroidetes, Rokubacteria, Firmicutes, and Nitrospirae) and five phoD phyla (i.e., Proteobacteria, Actinobacteria, Planctomycetes, Acidobacteria, and Firmicutes), respectively. Alpha diversity analysis indicated that the medium yield cotton field (MYF) exhibited higher bacterial richness and diversity indices compared to low yield (LYF) and high yield (HYF) fields. The symbiotic network analysis of LYF revealed greater values of average degree, number of edges, and modularity, suggesting a more complex network structure in both bacterial and phoD communities. The Mantel test, RDA, and PLS-PM model identified soil pH, electrical conductivity (EC), organic phosphorus (OP), available phosphorus (AP), total nitrogen (TN), microbial biomass carbon (MBC), and clay content as the main driving factors influencing changes in the rhizosphere bacterial community diversity and network structure.
Conclusion
These findings provide a theoretical basis for future research aimed at improving soil quality and cotton yield.
RANBP9 and RANBP10 cooperate in regulating non-small cell lung cancer proliferation
Authors: Orlacchio Arturo , Kajimura Yasuko , Rizzotto Lara , Tessari Anna , Soliman Shimaa H.A. , Visone Rosa , Zhang Liwen , Fries Brian , Tessarollo Lino , Amann Joseph , Carbone David P. , Lodi Alessia , Ahmed Amer , Fiermonte Giuseppe , Freitas Mike , Palmieri Dario , Kaufman Jacob , Coppola Vincenzo 
Published: February 2025

Abstract

Background
RANBP9 and RANBP10, also called Scorpins, are essential components of the C-terminal to LisH (CTLH) complex, an evolutionarily conserved poorly investigated multisubunit E3 ligase. Their role in non-small cell lung cancer (NSCLC) is unknown.
Methods
In this study, first we used stable loss-of function and overexpression inducible cell lines to investigate the ability of either RANBP9 or RANBP10 to form their own functional CTLH complex. Then, we probed lysates from patient tumors and analyzed data from publicly available repositories to investigate the expression of RANBP9 and RANBP10. Finally, we used inducible cell lines in vitro to recapitulate the expression observed in patients and investigate the changes of the proteome and the ubiquitylome associated with either RANBP9 or RANBP10 in NSCLC.
Results
Here, we show that the two Scorpins are both expressed in NSCLC cells and that either of them can independently support the formation of the CTLH complex. Short-term experiments revealed that the RANBP9 and RANBP10 proteins balance each other in terms of expression, and the acute overexpression of one or the other results in significant reshaping of the NSCLC cell proteome and ubiquitylome. A higher RANBP9/RANBP10 ratio is associated with greater proliferation in both NSCLC cell lines and patients. Acute increased expression of RANBP10 slows NSCLC cell proliferation and decreases the level of proliferation-associated proteins, including key players in DNA replication.
Conclusions
We present evidence that the Scorpins act as partial antagonists and work together as one sophisticated rheostat to modulate the CTLH complex ubiquitylation output, which regulates cell proliferation and other key biological processes in NSCLC. These results suggest that the two Scorpins can be considered as targets for the treatment of NSCLC.
Methyl Ethyl Ketone removal from Water via Pervaporation Using a Hydrophobic silicone-based Membrane
Authors: ShahBahrami Mohadese , Vahidi Omid , Farrokhzad Hasan , Poorkhalil Ali 
Published: February 2025

Abstract

The experimental study for the separation of methyl ethyl ketone (MEK) from water using the pervaporation membrane process with a polydimethylsiloxane (PDMS) membrane was conducted. Initially, several polymers were selected using Hansen solubility parameters, and ultimately, polydimethylsiloxane was chosen. In this study, ELASTOSIL® RT 601 A/B, which has a structure similar to polydimethylsiloxane, commercially known as Silgard 184, was used. This was confirmed through analyses such as FTIR, NMR, SEM, and water contact angle measurements, but the ELASTOSIL® RT 601 A/B was used at one-third of the price of Silgard 184. The feed was highly non-ideal and contained a heterogeneous azeotrope. The pervaporation experiments were performed at concentrations (5–15 wt%) and temperatures (40–60°C) under a vacuum pressure of 200 mbar. For a 5 wt% feed at 40°C, a total flux of 1.0208 kg/m²·h and a selectivity of 33 was achieved. Additionally, the effects of operational parameters, such as feed concentration and temperature, on the two factors of selectivity and flux were evaluated.
Effect of behavioural intervention package on empowerment and resilience among the pregnant women in India experiencing domestic violence: A facility-based randomized control trial
Authors: Mahapatro Meerambika , Roy Sudeshna , Nayar Poonam , Jadhav Ashwini , Panchkaran Suruchi , srivast divyanshu , Chandhok Gunjan , Prasad Sudha 
Published: February 2025

Abstract

Background
Women empowerment programs may reduce domestic violence (DV) by taking control of their lives. In a cognizant effort to empower pregnant women who have experienced DV, a Behaviour Intervention Package (BIP) was developed and used. It incorporates yoga-based techniques for self-development, interpersonal skill development, and awareness sessions. The study aims to assess the effects of a BIP on empowerment and resilience among pregnant women who have experienced violence and were attending antenatal care at a tertiary care hospital in India.
Methods
A randomised controlled trial was conducted with 211 pregnant women recruited between 18 to 20 weeks of pregnancy and randomly assigned to intervention (n = 105) or control (n = 106). The intervention group received behavioural intervention and standard care, while the control group received only standard care for 28 weeks. The study tools were completed once before the intervention and again at six weeks postnatal. The assessments were compared using methods as appropriate to estimate the effect size at baseline and post-intervention.
Results
The results showed that at a personal, relational, and socio-environmental level, the BIP intervention effectively improved quality of life, reduced DV, reduced stress and depression, and all parameters enabled women to develop a positive self-perception. They also reported being resilient and hopeful about their future.
Conclusion
The BIP may effectively empower pregnant women from low socioeconomic backgrounds facing DA in India, enhancing their quality of life. With no standardized intervention currently available, the BIP can be implemented in supportive settings to address the psychosocial health needs of women in distress and protect their health.
Trial registration
The Indian Registry of Clinical Trials number is CTRI/2019/01/017009 dated 9.1.2019.