bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unorthodox Conceptions of the Cartesian Mind, Inside and Outside the University of Leiden
Authors: Jaworzyn Michael 
Published: September 2023

Abstract
This chapter evaluates how the standard views of the Cartesian mind were revised and transformed in Arnold Geulincx’s own philosophical tradition. It addresses the developments within Geulincx’s works over his career, and in the works of two thinkers who wrote in his wake: Cornelis Bontekoe and Arnold Houbraken. When he moved to the University of Leiden in 1659, Geulincx’s teaching had to remain within the ‘bounds of the Aristotelian philosophy’ at first. It was presumably his apparent Cartesianism that worried the authorities. At some point in the course of his career, Geulincx held some apparently strange views of the mind that went far beyond what was standard (or acceptable) among Cartesians. Most strikingly, he refers to the mind as a ‘mode’ of the divine mind, a claim which many would have associated with Spinozism and atheism. Meanwhile, in his posthumous 1688 Metaphysica, Bontekoe denies the mind’s ability to change itself. Bontekoe thinks that each thought, each mode of thinking, remains as it is — the mind remains as it is — until something else changes it. For Houbraken, unlike the more unconventional strand of Geulincx’s work, the mind is a thinking thing in the ordinary Cartesian sense, and unlike for Bontekoe, it seems that it is capable of bringing things about within itself.
University Divinity and Intellectual Innovation in Eighteenth-Century Scotland
Authors: Raffe Alasdair 
Published: September 2023

Abstract
This chapter examines intellectual innovation in eighteenth-century Scotland which, as it shows, was strongly influenced by the country’s institutions. It relates this development with, particular reference to John Simson (1667–1740), professor of divinity at the University of Glasgow. Simson was twice prosecuted in the church courts for his alleged errors. As the chapter shows, however much that Scottish university divinity was transformed in the first half of the eighteenth century, its remoulding was not the result of any open assault on received doctrines, outright approval of heterodoxies, or enlightened campaign for free speech. Rather, the silences of divinity professors undermined the systematic quality of Reformed orthodoxy, producing a diluted Christianity. This simplified brand of Protestantism, the chapter concludes, coexisted with evolving forms of evangelical orthodoxy. John Simson and his trials, the chapter argues, may not have heralded the Scottish Enlightenment, but they contributed to the intellectual pluralisation of Scottish presbyterian culture.
“This World-Wide Need”
Authors: Jahanbani Sheyda F.A. 
Published: September 2023

Abstract
This chapter explores the global thought of John Collier and a transnational community of experts he brought together to address the conditions of “dependent” peoples. A Progressive Era social reformer, Collier encountered Native American poverty firsthand in the 1920s and became a lifelong advocate for indigenous people. As Franklin Roosevelt’s Bureau of Indian Affairs Commissioner, Collier drew on a vast network of social science experts in the United States and Mexico to reform policies toward native people. In 1941, as the US entered World War II, Collier established the Inter-American Indian Institute, from which he and his allies in Mexico collaborated to address the poverty of indigenous peoples throughout the Western Hemisphere. Identifying Indian poverty as a consequence of colonization, Collier used his position to create both demand and supply for new ideas about poverty in the emerging context of decolonization.
“Not Modern Men”
Authors: Jahanbani Sheyda F.A. 
Published: September 2023

Abstract
This chapter explores the creation of an explicitly cross-cultural theory of poverty, one that updated distinctions between rich and poor for an age of cultural relativism and global development. It revisits the life and work of anthropologist Oscar Lewis and his controversial “culture of poverty” theory. From Lewis’s work for John Collier’s Indian Personality Project in Mexico to his fieldwork in rural urban slums in Mexico, Puerto Rico, India, and the United States, this chapter reinterprets Lewis as a major theorist of “underdevelopment,” arguing that his culture of poverty thesis became one especially trenchant way of thinking about “world poverty” for policymakers in the 1960s.
Identifying child maltreatment during virtual medical appointments through the COVID-19 pandemic
Authors: Lim-Reinders Stephanie , Ward Michelle G K , Malic Claudia , Keely Kathryn , Kang Kristopher , Jain Nita , Zwicker Kelley 
Published: September 2023

Abstract

Background
Throughout the COVID-19 pandemic there has been a documented decline in reports to child protective services, despite an increased incidence of child maltreatment. This is concerning for increasing missed cases. This study aims to examine if and how Canadian paediatricians are identifying maltreatment in virtual medical appointments.

Methods
A survey was sent through the Canadian Paediatric Surveillance Program (CPSP) to 2770 practicing general and subspecialty paediatricians. Data was collected November 2021 to January 2022.

Results
With a 34% (928/2770) response rate, 704 surveys were eligible for analysis. At least one case of child maltreatment was reported by 11% (78/700) of respondents following a virtual appointment. The number of cases reported was associated with years in medical practice (P = 0.026) but not with the volume (P = 0.735) or prior experience (P = 0.127) with virtual care, or perceived difficulty in identifying cases virtually (Cramer’s V = 0.096). The most common factors triggering concern were the presence of social stressors, or a clear disclosure. The virtual physical exam was not contributory. Nearly one quarter (24%, 34/143) required a subsequent in-person appointment prior to reporting the case and 32% (207/648) reported concerns that a case had been identified late, or missed, following a virtual appointment. Some commented that clear harm resulted.

Conclusions
Many barriers to detecting child maltreatment were identified by paediatricians who used virtual care. This survey reveals that virtual care may be an important factor in missed cases of child maltreatment and may present challenges to timely identification.
Did Gender Egalitarianism Weaken Religiosity in Baby Boom Women? A Developmental-Historical Approach
Authors: Silverstein Merril , Hwang Woosang , Kim Jeung Hyun , Brown Maria T 
Published: September 2023

Abstract
This investigation used long-term longitudinal survey data from baby boomer women to identify whether strengthening gender role egalitarianism in early adulthood predicted declines in religious service attendance and religious intensity in later life. The aging of this cohort coincided with dramatic societal shifts in gender values and religiosity. The data were derived from 350 women participating in the Longitudinal Study of Generations, a study originally fielded in 1971 of families living in Southern California. Respondents were initially assessed in their late teens and early 20s and followed up to their early-to-mid 60s. Using growth curve modeling, we linked the change in egalitarian gender attitudes from 1971 to 1988 to a change in religiosity from 1994 to 2016. Women who became more egalitarian in their gender attitudes experienced sharper declines in religious intensity, but not in religious attendance in the period studied. Controlling for life-course transitions did not alter these results. The findings are discussed in terms of the connection between two asynchronous social changes occurring over the lives of women in a uniquely positioned birth cohort.
Mechanisms of Breast Cancer Stem Cell Specification and Self-Renewal Mediated by Hypoxia-Inducible Factor 1
Authors: Semenza Gregg L 
Published: September 2023

Abstract
Many advanced human cancers contain regions of intratumoral hypoxia, with O2 gradients extending to anoxia. Hypoxia-inducible factors (HIFs) are activated in hypoxic cancer cells and drive metabolic reprogramming, vascularization, invasion, and metastasis. Hypoxia induces breast cancer stem cell (BCSC) specification by inducing the expression and/or activity of the pluripotency factors KLF4, NANOG, OCT4, and SOX2. Recent studies have identified HIF-1-dependent expression of PLXNB3, NARF, and TERT in hypoxic breast cancer cells. PLXNB3 binds to and activates the MET receptor tyrosine kinase, leading to activation of the SRC non-receptor tyrosine kinase and subsequently focal adhesion kinase, which promotes cancer cell migration and invasion. PLXNB3-MET-SRC signaling also activates STAT3, a transcription factor that mediates increased NANOG gene expression. Hypoxia-induced NARF binds to OCT4 and serves as a coactivator by stabilizing OCT4 binding to the KLF4, NANOG, and SOX2 genes and by stabilizing the interaction of OCT4 with KDM6A, a histone demethylase that erases repressive trimethylation of histone H3 at lysine 27, thereby increasing KLF4, NANOG, and SOX2 gene expression. In addition to increasing pluripotency factor expression by these mechanisms, HIF-1 directly activates expression of the TERT gene encoding telomerase, the enzyme required for maintenance of telomeres, which is required for the unlimited self-renewal of BCSCs. HIF-1 binds to the TERT gene and recruits NANOG, which serves as a coactivator by promoting the subsequent recruitment of USP9X, a deubiquitinase that inhibits HIF-1α degradation, and p300, a histone acetyltransferase that mediates acetylation of H3K27, which is required for transcriptional activation.
Effects of simulated climate change conditions of increased temperature and [CO2] on the early growth and physiology of the tropical tree crop, Theobroma cacao L.
Authors: Mateus-Rodríguez Julián Fernando , Lahive Fiona , Hadley Paul , Daymond Andrew J 
Published: September 2023

Abstract
Despite multiple studies of the impact of climate change on temperate tree species, experiments on tropical and economically important tree crops, such as cacao (Theobroma cacao L.), are still limited. Here, we investigated the combined effects of increased temperature and atmospheric carbon dioxide concentration ([CO2]) on the growth, photosynthesis and development of juvenile plants of two contrasting cacao genotypes: SCA 6 and PA 107. The factorial growth chamber experiment combined two [CO2] treatments (410 and 700 p.p.m.) and three day/night temperature regimes (control: 31/22 °C, control + 2.5 °C: 33.5/24.5 °C and control + 5.0 °C: 36/27 °C) at a constant vapour pressure deficit (VPD) of 0.9 kPa. At elevated [CO2], the final dry weight and the total and individual leaf areas increased in both genotypes, while the duration for individual leaf expansion declined in PA 107. For both genotypes, elevated [CO2] also improved light-saturated net photosynthesis (Pn) and intrinsic water-use efficiency (iWUE), whereas leaf transpiration (E) and stomatal conductance (gs) decreased. Under a constant low VPD, increasing temperatures above 31/22 °C enhanced the rates of Pn, E and gs in both genotypes, suggesting that photosynthesis responds positively to higher temperatures than previously reported for cacao. However, dry weight and the total and individual leaf areas declined with increases in temperature, which was more evident in SCA 6 than PA 107, suggesting the latter genotype was more tolerant to elevated temperature. Our results suggest that the combined effect of elevated [CO2] and temperature is likely to improve the early growth of high temperature-tolerant genotypes, while elevated [CO2] appeared to ameliorate the negative effects of increased temperatures on growth parameters of more sensitive material. The evident genotypic variation observed in this study demonstrates the scope to select and breed cacao varieties capable of adapting to future climate change scenarios.
Multiple introductions and country-wide spread of DENV-2 genotype II (Cosmopolitan) in Brazil
Authors: Gräf Tiago , Ferreira Caroline Do Nascimento , de Lima Gustavo Barbosa , de Lima Raul Emídio , Machado Lais Ceschini , Campos Tulio de Lima , Schemberger Michelle Orane , Faoro Helisson , Paiva Marcelo Henrique Santos , Bezerra Matheus Filgueira , Nascimento Valdinete , Souza Victor , Nascimento Fernanda , Mejía Matilde , Silva Dejanane , de Oliveira Yasmin Silva , Gonçalves Luciana , Ramos Tatyana Costa Amorim , de Castro Daniel Barros , Arcanjo Ana Ruth , Dantas Herton Augusto Pinheiro , Presibella Mayra Marinho , Fernandes Sandra Bianchini , Gregianini Tatiana Schaffer , Paz E Silva Keilla Maria , Sacchi Claudio Tavares , Cruz Ana Cecília Ribeiro , Duarte dos Santos Claudia Nunes , Bispo de Filippis Ana Maria , Bello Gonzalo , Wallau Gabriel Luz , Salvato Richard Steiner , Naveca Felipe 
Published: September 2023

Abstract
Dengue virus serotype 2, genotype Cosmopolitan (DENV-2-GII), is one of the most widespread DENV strains globally. In the USA, DENV-2 epidemics have been dominated by DENV-2 genotype Asian-American (DENV-2-GIII), and the first cases of DENV-2-GII were only described in 2019, in Peru, and in 2021 in Brazil. To gain new information about the circulation of DENV-2-GII in Brazil, we sequenced 237 DENV-2 confirmed cases sampled between March 2021 and March 2023 and revealed that DENV-2-GII is already present in all geographic regions of Brazil. The phylogeographic analysis inferred that DENV-2-GII was introduced at least four times in Brazil, between May 2020 and August 2022, generating multiple clades that spread throughout the country with different success. Despite multiple introductions of DENV-2-GII, analysis of the country-wide laboratory surveillance data showed that the Brazilian dengue epidemic in 2022 was dominated by DENV-1 in most states. We hypothesize that massive circulation of DENV-2-GIII in previous years in Brazil might have created a population immune barrier against symptomatic homotypic reinfections by DENV-2-GII, leading to sustained cryptic circulation in asymptomatic cases and localized outbreaks of this new genotype. In summary, our study stresses the importance of arboviral genomic surveillance to close monitoring and better understanding the potential impact of DENV-2-GII in the coming years.
New sauropod dinosaur from the Lower Cretaceous of Morella (Spain) provides new insights on the evolutionary history of Iberian somphospondylan titanosauriforms
Authors: Mocho Pedro , Escaso Fernando , Gasulla José M , Galobart Àngel , Poza Begoña , Santos-Cubedo Andrés , Sanz José L , Ortega Francisco 
Published: September 2023

Abstract
A new somphospondylan titanosauriform from the Lower Cretaceous of Spain is described from the remains found at the Sant Antoni de la Vespa site (upper Barremian Arcillas de Morella Formation) located in Morella. Garumbatitan morellensis gen. et sp. nov. is diagnosed by 11 autapomorphies and eight local autapomorphies; and our phylogenetic analyses suggest that Garumbatitan morellensis might correspond to an early-branching somphospondylan. The presence of several somphospondylan traits in Garumbatitan morellensis supports the somphospondylan hypothesis. The phylogenetic distribution of some titanosauriform and somphospondylan novelties in the femur (markedly developed lateral bulge, high shaft eccentricity, linea intermuscularis cranialis, and trochanteric shelf) is discussed. The tarsus and pes of Garumbatitan morellensis are distinctive, being characterized by the loss of the calcaneum, relative slenderness of the metatarsals II, III, and IV when compared to the retracted metatarsals I and V, three pedal phalanges in digit IV, and reduced ungual III. The sauropod fauna of the Iberian Peninsula during the Hauterivian–Aptian shows a complex phylogenetic mosaic, including forms with Laurasian affinities, mainly titanosauriforms (Soriatitan, Garumbatitan, and possibly Tastavinsaurus and Europatitan), and Gondwanan affinities, the rebbachisaurid Demandasaurus. Faunal exchange during the Early Cretaceous between the Europe, North America, East Asia, and Africa is plausible.
Psychometric Properties of Patient-reported Outcome Measures to Assess Resilience in Individuals with Musculoskeletal Pain or Rheumatic Conditions
Authors: Rosa Dayana Patricia , Dubé Marc-Olivier , Roy Jean-Sébastien 
Published: September 2023

Objectives:
The objective of this systematic review was to provide a comprehensive overview of the measurement properties of patient-reported outcome measures (PROMs) used to assess resilience in individuals with musculoskeletal and rheumatic conditions.

Methods:
Four electronic databases (MEDLINE, CINAHL, PsycINFO, Web of Science) were searched. Studies assessing any measurement property in the target populations were included. Two reviewers independently screened all studies and assessed risk of bias using the COSMIN checklist. Thereafter, each measurement property of each PROM was classified as sufficient, insufficient, or inconsistent based on the COSMIN criteria for good measurement properties.

Results:
Four families of PROMs (Brief Resilient Coping Scale [BRCS]; Resilience Scale [RS-18]; Connor–Davidson Resilience Scale [CD-RISC-10 and CD-RISC-2]; and Pain Resilience Scale [PRS-14 and PRS-12]) were identified from the 9 included studies. Even if no PROM showed sufficient evidence for all measurement properties, the PRS and CD-RISC had the most properties evaluated and showed the best measurement properties; although responsiveness still needs to be assessed for both PROMs. Both PROMs showed good level of reliability (intraclass coefficient correlation 0.61 to 0.8) and good internal consistency (Cronbach’s alpha ≥0.70). Minimal detectable change values were 24.5% for PRS and between 4.7% and 29.8% for CD-RISC.

Discussion:
Although BRCS, RS-18, CD-RISC or PRS have been used to evaluated resilience in individuals with musculoskeletal and rheumatic conditions, the current evidence only supports the use of PRS or CD-RISC in this population. Further methodological studies are therefore needed and should prioritize the assessment of reliability and responsiveness.
Sleep Disruptions in Hospitalized Adults Sustaining a Traumatic Brain Injury: A Scoping Review
Authors: Leclerc Catherine , Gervais Charles , Hjeij Danny , Briand Marie-Michèle , Williamson David , Bernard Francis , Duclos Catherine , Arbour Caroline 
Published: September 2023

Objective:
Adults sustaining a traumatic brain injury (TBI) are at risk of sleep disturbances during their recovery, including when such an injury requires hospitalization. However, the sleep-wake profile, and internal and external factors that may interfere with sleep initiation/maintenance in hospitalized TBI patients are poorly understood. This review aimed to: (1) identify/summarize the existing evidence regarding sleep and sleep measurements in TBI adults receiving around-the-clock care in a hospital or during inpatient rehabilitation, and (2) identify internal/external factors linked to poor sleep in this context.

Methods:
A scoping review was conducted in accordance with the PRISMA Scoping Review Extension guidelines. A search was conducted in MEDLINE, PsycINFO, CINAHL, and Web of Science databases.

Results:
Thirty relevant studies were identified. The most common sleep variables that were put forth in the studies to characterize sleep during hospitalization were nighttime sleep time (mean = 6.5 hours; range: 5.2-8.9 hours), wake after sleep onset (87.1 minutes; range: 30.4-180 minutes), and sleep efficiency (mean = 72.9%; range: 33%-96%) using mainly actigraphy, polysomnography, and questionnaires (eg, the sleep-wake disturbance item of the Delirium Rating Scale or the Pittsburgh Sleep Quality Index). Twenty-four studies (80%) suggested that hospitalized TBI patients do not get sufficient nighttime sleep, based on the general recommendations for adults (7-9 hours per night). Sleep disruptions during hospitalization were found to be associated to several internal factors including TBI severity, cognitive status, and analgesia intake. External and modifiable factors, such as noise, light, and patient care, were consistently associated with sleep disruptions in this context.

Conclusion:
Although the literature on sleep disturbances in hospitalized TBI patients has been increasing in recent years, many gaps in knowledge remain, including phenotypes and risk factors. Identifying these factors could help clinicians better understand the multiple sources of TBI patients' sleep difficulties and intervene accordingly.
A CASE OF EPSTEIN–BARR VIRUS–ASSOCIATED PRIMARY VITREORETINAL LYMPHOMA IN AN IMMUNOSUPPRESSED PATIENT
Authors: Sun Chunxiao , Muraoka Yuki , Ishihara Kenji , Morooka Satoshi , Akada Masahiro , Hata Masayuki , Tsujikawa Akitaka 
Published: September 2023

Purpose:
To describe a rare case of Epstein–Barr virus (EBV)-positive primary vitreoretinal lymphoma in an immunosuppressed patient.

Methods:
Observational case report.

Results:
A 64-year-old man under immunosuppressive therapy for rheumatic arthritis was referred for 2 months of blurred vision and decreased visual acuity in the right eye. Only mutton-fat keratic precipitates and mild vitreous opacity were found in the right eye without (sub)retinal or sub-retinal pigment epithelial lesions. Vitreous biopsy and systemic workup suggested the diagnosis of primary vitreoretinal lymphoma of diffuse large B-cell lymphoma subform. Neoplastic cells stained positive for EBV antigens, EBV-encoded small RNA, and Epstein–Barr nuclear antigen 2, consistent with EBV-positive diffuse large B-cell lymphoma. Intravitreal methotrexate was effective in improving ocular symptoms.

Conclusion:
The case provided evidence on the association of EBV infection with primary vitreoretinal lymphoma.