bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative assessment of insomnia in recovering alcohol‐dependent patients
Authors: Zhabenko Olena , Linskiy Igor V. , Minko Oleksandr I. , Kuzminov Valeriy N. , Gmeinwieser Meike , Kiefer Lars P. , Conroy Deirdre A. 
Published: October 2023

AbstractInsomnia is a common symptom that may interfere with the efforts of alcohol‐dependent patients to initiate and maintain sobriety. This study investigates the experiences of recovering alcohol‐dependent patients with insomnia as well as preferences for treatment strategies. Semi‐structured interviews were conducted with 27 patients in Ukraine and Germany. Most of the patients experienced negative psychological (n = 21), physiological (n = 14) effects and negative daytime consequences during insomnia. All 27 patients were engaged in nonpharmacological approaches to insomnia and 52% used pharmacological approaches to manage insomnia. This study provides insight for understanding how alcohol‐dependent patients in recovery perceive insomnia.
Copper‐PCL/PVP virucidal nanofibers against coronavirus produced by electrospinning technology
Authors: de Moraes Segundo João de Deus Pereira , Calais Guilherme Bedeschi , Constantino Jamilly Salustiano Ferreira , de Moura Junior Celso Fidelis , de Souza Francisco Fábio Pereira , Andrade Fábia Karine , de Moraes Maria Oneide Silva , d'Ávila Marcos Akira , Tsukamoto Junko , Arns Clarice Weis , Beppu Marisa Masumi , Vieira Rodrigo Silveira 
Published: October 2023

AbstractThis work investigated the virucidal property of copper‐loaded poly(ε‐caprolactone) (PCL)/polyvinylpyrrolidone (PVP) blended nanofibers against coronavirus. Electrospinning solutions were prepared with 0.25, 0.75, and 1.50% [w/v] of copper salt and their properties of electrical conductivity, surface tension, and viscosity were measured. The copper‐PCL/PVP nanofibers produced electrospun composite membranes of 30.5–38 g m−2. IR spectra confirmed the blended PCL/PVP, and SEM/EDS images revealed the morphology of the randomly oriented nanofibers with homogeneously incorporated copper in the electrospun nanofibers. The copper quantification indicated the final incorporation of 5.50 ± 0.31, 14.00 ± 1.03, and 27.10 ± 3.00 mg g−1 of copper, as measured by atomic absorption spectrometry, into electrospun composite membranes for 0.25, 0.75, and 1.50% [w/v] copper solution formulations, respectively, and these compositions also affected the nanofibers mechanical properties. Copper release assays showed that copper‐PCL/PVP nanofibers readily release ions into aqueous media. The 0.75% copper‐PCL/PVP composite membrane was virucidal against coronavirus, reaching 99.99% inactivation in 1 hour and 99.999% inactivation in 24 h, and non‐cytotoxic to L929 cells in 24 h of exposure. This work presents a virucidal composite membrane with potential use in personal protective equipment against viral outbreaks or pandemics.
Validating repurposed GAD‐7 anchored in COVID‐19 pandemic experiences: A factor‐ and person‐centered approach
Authors: Mordeno Imelu G. , Gallemit I Marie Joy S. , Ducay Judith L. , Abdullah Sittiehara P. , Suba Salihah Marjannah S. , Edaros Nashren D. 
Published: October 2023

AbstractGeneralized Anxiety Disorder 7‐item Scale (GAD‐7) has been found to accurately assess the presence of generalized anxiety disorder (GAD) in various populations. However, despite showing good psychometric properties in assessing GAD symptoms, there is a need to further validate GAD‐7 in milieu of the pandemic, considering that recent cross‐sectional studies have utilized this scale in understanding GAD prevalence and risk factors. The present study aimed to contextualize the GAD‐7 scale into the present condition through investigating its (1) factor structure, (2) measurement invariance, and (3) latent classes. This study utilized 1922 (63.4%) secondary and 1110 (36.6%) tertiary Filipino teachers. Confirmatory factor analyses showed that the scale is best represented by two factors: cognitive–emotional experiences and somatic experiences. Moreover, the results revealed that while the two‐factor GAD model showed good measurement equivalence across teacher groups, measurement non‐invariance was observed in gender groups. Lastly, the latent class analysis yielded a three‐class solution best fitting to the data. It specifically grouped GAD symptom intensity as low, moderate, and severe anxiety groups. These findings provide evidence of the scale's validity, supporting the utilization of the GAD‐7 scale in assessing pandemic‐related generalized anxiety.
Alleviating learning burnout of Chinese middle school students by school‐based mindfulness training: The mediating role of psychological resilience
Authors: Liu Xianhua , Lei Lei , Zheng Yanli , Deng Yu , Chen Jiajing 
Published: October 2023

AbstractThis study aimed to explore the effectiveness of school‐based mindfulness training on learning burnout of Chinese middle school students and the mediating role of psychological resilience between dispositional mindfulness and learning burnout. A cluster randomized controlled trial was conducted with repeated measurement analysis, in which 62 Chinese middle school students in the experimental group received a 10‐week school‐based mindfulness training. In comparison, 63 students in the control group were randomized to receive no intervention. Learning burnout, dispositional mindfulness, and psychological resilience were measured by Adolescent Student Burnout Inventory, Five Facet Mindfulness Questionnaire, and Resilience Scale for Chinese Adolescents, respectively. The results showed: (1) Compared with the experimental group's pre‐test scores and the control group's pretest and posttest scores, the posttest scores of learning burnout in the experimental group significantly decreased. In contrast, the posttest scores of dispositional mindfulness and psychological resilience in the experimental group significantly increased. Meanwhile, the control group gained no significant changes between the pre‐and posttest in learning burnout, dispositional mindfulness, and psychological resilience. (2) Dispositional mindfulness was positively related to psychological resilience, while dispositional mindfulness and psychological resilience were negatively associated with learning burnout. (3) The direct effect of dispositional mindfulness on learning burnout and the mediating effect of psychological resilience between dispositional mindfulness and learning burnout were significant. This study suggested that school‐based mindfulness training distinctly improves dispositional mindfulness and psychological resilience and alleviates learning burnout in Chinese middle school students. Furthermore, psychological resilience plays a mediating role between dispositional mindfulness and learning burnout.
Registration of ‘ARTPEA‐204B’, an early‐maturing cowpea cultivar for the southern agro‐ecology of Nigeria, with high fodder, high grain yield and reduced need for insecticidal spray
Authors: Obafemi Obajimi A. , Owolade Oluwaferanmi F. , Olasoji Julius O. , Olakojo Samuel A. , Adamu Rabiu S. , Agboola Adebayo A. , Obembe Michael O. 
Published: October 2023

AbstractCowpea [Vigna ungiculata (L.) Walp] production is affected by numerous constraints such as insect pests, diseases (fungal, viral, and bacterial), poor soil fertility, metal toxicity, drought, and excessive rainfall. The high cost of input, especially pesticides, also contributes to the reduction of cowpea yield potential in sub‐Saharan Africa. ‘ARTPEA‐204B’ (Reg. no. CV‐351, PI 702792; National code NGVU‐22‐38), also known as Modupe, was developed through a cross between ‘Ife Brown’ and a wild cowpea landrace and release by the Institute of Agricultural Research and Training, Obafemi Awolowo University, Moor Plantation, Ibadan, Nigeria, in 2022. It was bred for early maturing, high grain and fodder yield, and reduced insecticidal spray for the southern agro‐ecologies of Nigeria. ARTPEA‐204B along with Ife Brown and other cowpea lines were evaluated under farmer's management conditions in an on‐farm trial conducted in 30 communities in 15 local government areas of Ondo, Ekiti, Osun, and Oyo States in 2021 under farmers’ condition. ARTPEA‐204B is early maturing (69–72 days), high‐yielding fodder (4500 kg/ha) and grain (1.29 t/ha), photoperiod insensitive, reduce spray, and adaptable to all agro‐ecologies in southern Nigeria.
Inhibition of N‐myristoyltransferase activity promotes androgen receptor degradation in prostate cancer
Authors: Alsaidan Omar Awad , Onobun Emmanuel , Ye Chenming , Lou Lei , Beharry Zanna , Xie Zhong‐Ru , Lebedyeva Iryna , Crich David , Cai Houjian 
Published: October 2023

AbstractBackgroundEven though prostate cancer (PCa) patients initially respond to androgen deprivation therapy, some will eventually develop castration resistant prostate cancer (CRPC). Androgen receptor (AR) mediated cell signaling is a major driver in the progression of CRPC while only a fraction of PCa becomes AR negative. This study aimed to understand the regulation of AR levels by N‐myristoyltransferase in PCa cells.MethodsTwo enantiomers, (1S,2S)‐
d‐NMAPPD and (1R,2R)‐
d‐NMAPPD (LCL4), were characterized by various methods (1H and 13C NMR, UHPLC, high‐resolution mass spectra, circular dichroism) and evaluated for the ability to bind to N‐myristoyltransferase 1 (NMT1) using computational docking analysis. structure–activity relationship analysis of these compounds led to the synthesis of (1R,2R)‐LCL204 and evaluation as a potential NMT1 inhibitor utilizing the purified full length NMT1 enzyme. The NMT inhibitory activity wase determined by Click chemistry and immunoblotting. Regulation of NMT1 on tumor growth was evaluated in a xenograft tumor model.Results(1R,2R)‐
d‐NMAPPD, but not its enantiomer (1S,2S)‐
d‐NMAPPD, inhibited NMT1 activity and reduced AR protein levels. (1R,2R)‐LCL204, a derivative of (1R,2R)‐
d‐NMAPPD, inhibited global protein myristoylation. It also suppressed protein levels, nuclear translocation, and transcriptional activity of AR full‐length or variants in PCa cells. This was due to enhanced ubiquitin and proteasome‐mediated degradation of AR. Knockdown of NMT1 levels inhibited tumor growth and proliferation of cancer cells.ConclusionInhibitory efficacy on N‐myristoyltransferase activity by d‐NMAPPD is stereospecific. (1R,2R)‐LCL204 reduced global N‐myristoylation and androgen receptor protein levels at low micromolar concentrations in prostate cancer cells. pharmacological inhibition of NMT1 enhances ubiquitin‐mediated proteasome degradation of AR. This study illustrates a novel function of N‐myristoyltransferase and provides a potential strategy for treatment of CRPC.
Electron ionization fragmentation studies for a series of 4‐methoxymethylene benzoate esters
Authors: Abiedalla Younis , Clark C. Randall 
Published: October 2023

RationaleProduct ion studies and stable isotope deuterium labeling experiments provide useful data for understanding the electron ionization (EI)‐mass spectroscopy (MS) fragmentation of methoxymethylene substituted benzoate esters. The methoxymethylene ether is regioisomeric with the ethoxy group and represents the two possible ether substituents of a benzene ring of C2H5O. Structural confirmation of these synthetic precursor materials via gas chromatography (GC)–EI‐MS revealed unexpected fragment ions. The synthesis and EI‐MS evaluation of some homologs and deuterated derivatives allowed for the characterization of these unique ions and their fragmentation pathways. The relative effects of the position of the oxygen of the ether side chain are the subject of this investigation.MethodsThe desired compounds were prepared from 4‐chloromethylbenzoyl chloride by alkoxide displacement followed by transesterifications and the deuterated analogs were prepared similarly. The compounds were separated by capillary GC and their MS fragmentation evaluated in EI, MS/MS and chemical ionization experiments.ResultsThe methoxymethylene‐substituted benzoate esters yield major fragment ions from the loss of the alkyl group from the ether as well as alkoxy group loss from the ester or ether portion of the molecule. The loss of the alkyl group from the ether followed by loss of the ester alkoxy group as the corresponding alcohol yielded the unique cation at m/z 133 for all compounds. The identity of the major ions was confirmed by product ion and deuterium labeling studies and possible mechanisms of fragment ion formation are described.ConclusionsThe aliphatic oxygen of the alkoxymethylene group plays a much more active role in the EI‐MS fragment formation profile than the direct aromatic ring linked oxygen of the ethoxy group. Thus, yielding a greater variety of characteristic fragments. The m/z 133 ion is unique to this class of compounds and does not have an equivalent pathway for the regioisomeric ethoxy series.
Learning to be entrepreneurial: Do family firms gain more from female leadership than nonfamily firms?
Authors: Hernández‐Linares Remedios , López‐Fernández María Concepción , Eddleston Kimberly A. , Kellermanns Franz 
Published: October 2023

AbstractResearch SummaryWe integrate social learning theory with gender role congruity theory to propose that family firms gain more from female leadership than nonfamily firms due to the congruence of female communal values with those of a family business. Results of our empirical study, based on a sample of 322 Spanish small‐ and medium‐sized enterprises (SMEs), show that while all three dimensions of learning orientation (commitment to learning, shared vision, and open‐mindedness) are positively related to an entrepreneurial orientation, significant differences exist based on the CEO's gender and whether the SME is a family or nonfamily firm. Strongest differences were found between female‐led family and nonfamily SMEs whereby the entrepreneurial orientation of female‐led family SMEs benefited significantly more from their firm's commitment to learning and open‐mindedness.Managerial SummaryTo cultivate entrepreneurship, a small‐ and medium‐sized enterprise (SME) leader must create an organization that fosters learning. Yet, surprisingly, we know little about male and female leaders' ability to translate their SME's learning into entrepreneurship. Our study reveals that in comparison to nonfamily firms, family firms offer an environment that is more conducive to supporting women leaders, which allows their female leaders to direct their SME's learning more effectively toward entrepreneurship. However, while female‐led family SMEs were as effective as male‐led family‐ and nonfamily‐led SMEs in directing learning toward entrepreneurship, female‐led nonfamily SMEs struggled. Our study therefore suggests that while women have an advantage leading family SMEs, gender biases hamper female leaders' ability to transform learning into greater entrepreneurial orientation in nonfamily SMEs.
Modification and crosslinking strategies for hyaluronic acid‐based hydrogel biomaterials
Authors: Luo Zhiqiang , Wang Yu , Xu Ye , Wang Jinglin , Yu Yunru 
Published: October 2023

AbstractHyaluronic acid (HA) is an attractive extracellular matrix‐derived polymer. The related HA‐based hydrogels are emerging to be the hotspots in the cutting edge of biomaterials. The continuous sights concentrate on exploring modification methods and crosslinking strategies to promote the advancement of HA‐based hydrogels with enhanced physical/chemical properties and enriched biological performance. Here, the advances on modification methods and crosslinking strategies for fabricating HA‐based hydrogels with diverse capacities are summarized. Firstly, the modification reactions that occur on the active hydroxyl, carboxyl and N‐acetyl groups of HA molecule are discussed. Next, the emphasis is put on various crosslinking strategies including physical crosslinking, covalent crosslinking and dynamic covalent crosslinking. Finally, we provide a general summary and give a critical viewpoint on the remaining challenges and the future development of HA‐based hydrogels. It is hoped that this review can provide new proposals for the specific design of functional hydrogel biomaterials.
Photothermal‐Enhanced Dual Inhibition of Lactate/Kynurenine Metabolism for Promoting Tumor Immunotherapy
Authors: Xie Yulin , Wang Man , Qiao Luying , Qian Yanrong , Xu Wencheng , Sun Qianqian , Luo Shuiping , Li Chunxia 
Published: October 2023

AbstractTraditionally referred to as “metabolic junk”, lactate has now been recognized as essential “energy currency” and crucial “messenger” that contributes to tumor evolution, immunosuppression, etc., thus presenting a promising strategy for antitumor interventions. Similarly, kynurenine (Kyn) also exerts an immunosuppressive function, thereby significantly compromising the effectiveness of immunotherapy. This study proposes and validates a strategy for enhancing immunotherapy through photothermal‐assisted depletion of lactate sustained by cycle‐like O2 supply, with blocking the tryptophan (Trp)/Kyn metabolic pathway. In brief, a nanozyme therapeutic agent (PNDPL) is constructed, which mainly consists of PtBi nanozymes, lactate oxidase (LOX) and the indoleamine 2,3‐dioxygenase (IDO) inhibitor NLG919. The PtBi nanozymes, which exhibit a catalase (CAT)‐like activity, form a positive feedback loop with LOX to consume lactate while self‐supplying O2. Moreover, PtBi nanozymes retain enzyme‐like performance even in a slightly acidic tumor microenvironment. Under 1064 nm irradiation, photothermal therapy (PTT) not only induces tumor cell death but also accelerates lactate exhaustion. Therefore, the combination of lactate depletion‐induced starvation therapy and PTT, along with the blocking of IDO‐mediated immune escape, effectively inhibits tumor growth and reverses immunosuppressive microenvironment, thus preventing tumor metastasis. This study represents the first investigation into the synergistic antitumor effects by lactate metabolism regulation and IDO‐related immunotherapy.
Impact of genotype‐calling methodologies on genome‐wide association and genomic prediction in polyploids
Authors: Njuguna Joyce N. , Clark Lindsay V. , Lipka Alexander E. , Anzoua Kossonou G. , Bagmet Larisa , Chebukin Pavel , Dwiyanti Maria S. , Dzyubenko Elena , Dzyubenko Nicolay , Ghimire Bimal Kumar , Jin Xiaoli , Johnson Douglas A. , Kjeldsen Jens Bonderup , Nagano Hironori , de Bem Oliveira Ivone , Peng Junhua , Petersen Karen Koefoed , Sabitov Andrey , Seong Eun Soo , Yamada Toshihiko , Yoo Ji Hye , Yu Chang Yeon , Zhao Hua , Munoz Patricio , Long Stephen P. , Sacks Erik J. 
Published: October 2023

AbstractDiscovery and analysis of genetic variants underlying agriculturally important traits are key to molecular breeding of crops. Reduced representation approaches have provided cost‐efficient genotyping using next‐generation sequencing. However, accurate genotype calling from next‐generation sequencing data is challenging, particularly in polyploid species due to their genome complexity. Recently developed Bayesian statistical methods implemented in available software packages, polyRAD, EBG, and updog, incorporate error rates and population parameters to accurately estimate allelic dosage across any ploidy. We used empirical and simulated data to evaluate the three Bayesian algorithms and demonstrated their impact on the power of genome‐wide association study (GWAS) analysis and the accuracy of genomic prediction. We further incorporated uncertainty in allelic dosage estimation by testing continuous genotype calls and comparing their performance to discrete genotypes in GWAS and genomic prediction. We tested the genotype‐calling methods using data from two autotetraploid species, Miscanthus sacchariflorus and Vaccinium corymbosum, and performed GWAS and genomic prediction. In the empirical study, the tested Bayesian genotype‐calling algorithms differed in their downstream effects on GWAS and genomic prediction, with some showing advantages over others. Through subsequent simulation studies, we observed that at low read depth, polyRAD was advantageous in its effect on GWAS power and limit of false positives. Additionally, we found that continuous genotypes increased the accuracy of genomic prediction, by reducing genotyping error, particularly at low sequencing depth. Our results indicate that by using the Bayesian algorithm implemented in polyRAD and continuous genotypes, we can accurately and cost‐efficiently implement GWAS and genomic prediction in polyploid crops.
Serratia marcescens‐associated subcutaneous abscess in a dog
Authors: Koo Yoonhoi , Yun Taesik , Chae Yeon , Lee Dohee , Yu Hogeun , Cha Sijin , Kim Hakhyun , Yang Mhan‐Pyo , Kang Byeong‐Teck 
Published: October 2023

AbstractThis report describes the clinical presentation and progression of a Serratia marcescens‐associated subcutaneous abscess in a dog with hypothyroidism, hyperadrenocorticism and diabetes mellitus. The S. marcescens isolate was resistant to several antibiotics. Treatment with antibiotics and topical antiseptics was not successful.
A Natural History of the Emirates: An Introduction
Authors: Burt John A. 
Published: October 2023

AbstractIn recent decades there has been a dramatic increase in research on the natural history of the United Arab Emirates (UAE), driven by the growing interest of both amateur and professional naturalists to deepen our understanding of the patterns and processes that structure life across this environmentally unique young nation. A Natural History of the Emirates summarizes this knowledge, providing a current and comprehensive overview of the UAE’s natural environment, emphasizing its unique ecosystems, diverse flora and fauna, and human interactions with these fragile habitats. By shedding light on the physical environment of the Emirates, including the major terrestrial and marine ecosystems, and the uniquely adapted flora and fauna found in the UAE, this book provides invaluable insights into the intricate and interconnected web of life in this environmentally distinct region. Furthermore, the book explores the complex relationship between humans and the environment in the UAE, examining how positive changes under economic development have sometimes come at a cost to nature, and in other cases has created new habitat for human-associated communities. A Natural History of the Emirates serves as an essential foundation for those seeking to contribute to the vital mission of preserving and protecting the rich natural heritage of the United Arab Emirates for future generations.
Seaweeds of the Emirates
Authors: John David M. 
Published: October 2023

AbstractSeaweeds, Cyanobacteria, seagrasses and mangroves are the principal inshore primary producers in the southern basin of the Arabian Gulf. Of these the seaweeds are by far the most diverse with about 120 species recorded from those Emirates bordering the region. Little is still known of the seaweed floras of the two Emirates within the Gulf of Oman (Fujairah, Sharjah). Briefly discussed are the very extensive cyanobacterial mats association with inshore sedimentary environments. Described are the bands of seaweeds, cyanobacteria and sessile animals that are a feature of the intertidal of rocky shores. Much consideration is given to the striking forest-like community that develops seasonally on shallow and often seaward sloping rocky platforms. Large foliose brown seaweeds are the canopy dominants of this community that develops rapidly over the months of lowest sea temperature (‘winter’). Many of these seaweeds decay and are lost during the early summer resulting in a striking transformation of the seascape when the understory of smaller mat/turf-forming and crustose coralline seaweeds becomes evident. Since the late 1990s there has been a ‘phase shift’ with seaweeds replacing stony corals as the spatial dominants on many rocky platforms. The ecological significance of the large biomass of dead and decaying seaweed produced in early summer is discussed. Briefly mentioned are seaweeds as providers of ecosystem services.