bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolonged Jaundice in a Premature Breastfed Infant With Gilbert’s Syndrome
Authors: Strobl Frances , Theurich Melissa Ann 
Published: February 2024

Introduction: Neonatal jaundice and prematurity pose significant barriers to breastfeeding in the first days of life. There is limited literature exploring the relationship between prolonged jaundice in breastfed infants and Gilbert’s (Meulengraght) syndrome. This case study describes the diagnostic and therapeutic challenges associated with Gilbert’s syndrome in a late preterm breastfed infant born in Germany. Main Issue: In this case report, an infant born to a primipara woman presented at 3 weeks postpartum to an International Board Certified Lactation Consultant. The initial assessment revealed a late preterm infant with inadequate weight gain and jaundice. The dyad received breastfeeding support and eventually achieved adequate weight gain; however, the infant’s jaundice persisted. Management: The consulting midwife suggested that the persistent jaundice was “breastmilk jaundice” and recommended temporarily interrupting breastfeeding. Due to a suspected family history of Gilbert’s Syndrome, the dyad was referred, instead, to a pediatric gastroenterologist. Pathologic liver disease was excluded, and genetic testing confirmed Gilbert’s Syndrome. At 6 months of age, the dyad was successfully breastfeeding and beginning complementary feeding. Conclusion: Genetic testing for Gilbert’s Syndrome should be considered for infants with prolonged jaundice and positive family history. Interruption or cessation of breastfeeding are not evidence-based recommendations, and current guidelines do not support these practices. Lactation professionals play a critical role in the management of breastfeeding for preterm infants with prolonged jaundice and should refer to specialists to rule out pathologic etiologies.
Manual versus automated chemotherapy preparation: A retrospective pharmaco-economic analysis
Authors: Chennaq Meryem , El Baraka Soumaya , Cherif Chefchaouni Ali , Benahmed Houda , Chaibi Aicha , Belahcen Mohammed-Jaouad , Rahali Younes 
Published: February 2024

Introduction The National Oncology Institute of Morocco's (NIO) shift to an automated cytotoxic drug preparation system (PHARMODUCT®) has prompted an evaluation of its economic and clinical impacts compared to traditional manual methods. Methods A retrospective cost-benefit analysis over six months, extrapolated to annual projections, assessed initial investments, labour, equipment, drugs and consumables. Four commonly used chemotherapy drugs were analyzed, with a focus on the cost implications of drug waste in manual preparation versus the efficiency of vial-sharing in automated methods. Results The automated system incurred a higher initial cost $2,934,098.74, but reduced annual drug consumption costs by 19.74% and drug-related expenses by $41,228.27. It also decreased personnel costs by $48,073.35. Despite the upfront investment, the system is projected to break even within two years, with no medication waste due to its vial-sharing capability. Conclusion The initial higher investment in pharmaceutical automation promises considerable long-term savings and efficiency gains. Despite the study's limited scope and duration, the findings endorse the adoption of automated systems in oncology pharmacy settings for sustainable financial management and improved clinical outcomes.
In Memoriam: Professor Joseph Biederman’s Contributions to Child and Adolescent Psychiatry
Authors: Faraone Stephen V. , Newcorn Jeffrey H. , Wozniak Janet , Joshi Gagan , Coffey Barbara , Uchida Mai , Wilens Timothy , Surman Craig , Spencer Thomas J. 
Published: February 2024

Objective: To provide an overview of Joe Biederman’s contributions to child and adolescent psychiatry. Method: Nine colleagues described his contributions to: psychopharmacology, comorbidity and genetics, pediatric bipolar disorder, autism spectrum disorders, Tourette’s and tic disorders, clinical and neuro biomarkers for pediatric mood disorders, executive functioning, and adult ADHD. Results: Joe Biederman left us with many concrete indicators of his contributions to child and adolescent psychiatry. He set up the world’s first pediatric psychopharmacology clinic and clinical research program in child adolescent psychiatry. As a young faculty member he began a research program that led to many awards and eventual promotion to full professor at Harvard Medical School. He was for many years the most highly cited researcher in ADHD. He achieved this while maintaining a full clinical load and was widely respected for his clinical acumen. Conclusion: The world is a better place because Joe Biederman was here.
Disentangling multiple sclerosis phenotypes through Mendelian disorders: A network approach
Authors: Bellucci Gianmarco , Buscarinu Maria Chiara , Reniè Roberta , Rinaldi Virginia , Bigi Rachele , Mechelli Rosella , Romano Silvia , Salvetti Marco , Ristori Giovanni 
Published: February 2024

Background: The increasing knowledge about multiple sclerosis (MS) pathophysiology has reinforced the need for an improved description of disease phenotypes, connected to disease biology. Growing evidence indicates that complex diseases constitute phenotypical and genetic continuums with “simple,” monogenic disorders, suggesting shared pathomechanisms. Objectives: The objective of this study was to depict a novel MS phenotypical framework leveraging shared physiopathology with Mendelian diseases and to identify phenotype-specific candidate drugs. Methods: We performed an enrichment testing of MS-associated variants with Mendelian disorders genes. We defined a “MS-Mendelian network,” further analyzed to define enriched phenotypic subnetworks and biological processes. Finally, a network-based drug screening was implemented. Results: Starting from 617 MS-associated loci, we showed a significant enrichment of monogenic diseases ( p < 0.001). We defined an MS-Mendelian molecular network based on 331 genes and 486 related disorders, enriched in four phenotypic classes: neurologic, immunologic, metabolic, and visual. We prioritized a total of 503 drugs, of which 27 molecules active in 3/4 phenotypical subnetworks and 140 in subnetwork pairs. Conclusion: The genetic architecture of MS contains the seeds of pathobiological multiplicities shared with immune, neurologic, metabolic and visual monogenic disorders. This result may inform future classifications of MS endophenotypes and support the development of new therapies in both MS and rare diseases.
Decreased PDLIM1 expression in endothelial cells contributes to the development of intracranial aneurysm
Authors: Yan Yan , Qin Xuanfeng , Zheng Yongtao , Jin Tao , Hu Yuanyuan , An Qingzhu , Leng Bing 
Published: February 2024

Introduction: Intracranial aneurysm (IA) is a common vascular enlargement that occurs in the wall of cerebral vessels and frequently leads to fatal subarachnoid hemorrhage. PDZ and LIM domain protein 1 (PDLIM1) is a cytoskeletal protein that functions as a platform for multiple protein complex formation. However, whether PDLIM is involved in the pathogenesis of IA remains poorly understood. Methods: Loss-of-function and gain-of-function strategies were employed to determine the in vitro roles of PDLIM1 in vascular endothelial cells (VECs). A rat model of IA was generated to study the role of PDLIM1 in vivo. Gene expression profiling, Western blotting, and dual luciferase reporter assays were performed to uncover the underlying cellular mechanism. Clinical IA samples were used to determine the expression of PDLIM1 and its downstream signaling molecules. Results: PDLIM1 expression was reduced in the endothelial cells of IA and was regulated by Yes-associated protein 1 (YAP1). Genetic silencing of PDLIM1 inhibited the viability, migratory ability, and tube formation ability of VECs. Opposite results were obtained by ectopic expression of PDLIM1. Additionally, PDLIM1 overexpression mitigated IA in vivo. Mechanistic investigations revealed that PDLIM1 promoted the transcriptional activity of β-catenin and induced the expression of v-myc myelocytomatosis viral oncogene homolog (MYC) and cyclin D1 (CCND1). In clinical settings, reduced expression of PDLIM1 and β-catenin downstream target genes was observed in human IA samples. Conclusion: Our study indicates that YAP1-dependent expression of PDLIM1 can inhibit IA development by modulating the activity of the Wnt/β-catenin signaling pathway and that PDLIM1 deficiency in VECs may represent a potential marker of aggressive disease.
Venous thromboembolic outcomes in patients with lymphedema and lipedema: An analysis from the National Inpatient Sample
Authors: Khalid Muhammad Umar , Prasada Sameer , Jennings Courtney , Bartholomew John R , McCarthy Meghann , Hornacek Deborah A , Joseph Douglas , Chen Wei , Schwarz Graham , Bhandari Rohan , Elbadawi Ayman , Cameron Scott J 
Published: February 2024

Background: Patients with lymphedema and lipedema share physical exam findings that may lead to misdiagnosis. Poor mobility is common in patients with obesity and patients with lymphedema and lipedema. This may constitute a risk factor for venous thromboembolism (VTE). Our objective was to evaluate the association of VTE in obese patients with lymphedema and lipedema. Methods: The National Inpatient Sample (NIS) was searched from 2016 to 2020 to identify hospital admissions of obese female patients with lymphedema and lipedema. Patients were analyzed in the context of presence or absence of VTE while adjusting for complex cluster sampling techniques. Predictors of VTE were accessed by multivariable regression. Results: Lymphedema was identified in 189,985 patients and lipedema in 50,645 patients. VTE was observed in 3.12% ( n = 374,210) of patients with obesity. In patients with obesity, VTE was more common in patients with lymphedema than without (2.6% vs 1.6%; p < 0.01). Similarly, VTE was more common in patients with lipedema than without (0.6% vs 0.4%; p < 0.01). After multivariable logistic regression, VTE events in obese patients with lymphedema were higher versus without (OR 1.6; CI 1.08–2.43; p = 0.02). Similarly, VTE events were more common in obese patients with lipedema versus obese patients without lipedema (OR 1.20; CI 1.03–1.41; p = 0.02). Conclusions: In this hypothesis-generating study, lymphedema and lipedema show a positive association with VTE after adjusting for baseline patient characteristics such as obesity, which is a known independent risk factor for VTE. Mechanisms whereby lymphedema and lipedema are associated with VTE should be investigated.
Dysregulated platelet function in patients with postacute sequelae of COVID-19
Authors: Aggarwal Anu , Singh Tamanna K , Pham Michael , Godwin Matthew , Chen Rui , McIntyre Thomas M , Scalise Alliefair , Chung Mina K , Jennings Courtney , Ali Mariya , Park Hiijun , Englund Kristin , Khorana Alok A , Svensson Lars G , Kapadia Samir , McCrae Keith R , Cameron Scott J 
Published: February 2024

Background: Postacute sequelae of COVID-19 (PASC), also referred to as “Long COVID”, sometimes follows COVID-19, a disease caused by SARS-CoV-2. Although SARS-CoV-2 is well known to promote a prothrombotic state, less is known about the thrombosis risk in PASC. Our objective was to evaluate platelet function and thrombotic potential in patients following recovery from SARS-CoV-2, but with clear symptoms of patients with PASC. Methods: patients with PASC and matched healthy controls were enrolled in the study on average 15 months after documented SARS-CoV-2 infection. Platelet activation was evaluated by light transmission aggregometry (LTA) and flow cytometry in response to platelet surface receptor agonists. Thrombosis in platelet-deplete plasma was evaluated by Factor Xa activity. A microfluidics system assessed thrombosis in whole blood under shear stress conditions. Results: A mild increase in platelet aggregation in patients with PASC through the thromboxane receptor was observed, and platelet activation through the glycoprotein VI (GPVI) receptor was decreased in patients with PASC compared to age- and sex-matched healthy controls. Thrombosis under shear conditions as well as Factor Xa activity were reduced in patients with PASC. Plasma from patients with PASC was an extremely potent activator of washed, healthy platelets – a phenomenon not observed when stimulating healthy platelets after incubation with plasma from healthy individuals. Conclusions: patients with PASC show dysregulated responses in platelets and coagulation in plasma, likely caused by a circulating molecule that promotes thrombosis. A hitherto undescribed protective response appears to exist in patients with PASC to counterbalance ongoing thrombosis that is common to SARS-CoV-2 infection.
Respiratory impairments in patients suffering from Fabry disease – A cross-sectional study
Authors: Ahmed Huma , Backer Vibeke , Effraimidis Grigoris , Rasmussen Åse Krogh , Kistorp Caroline Michaela , Feldt-Rasmussen Ulla 
Published: February 2024

Background The inherited X-linked disorder, Fabry disease, is caused by deficient lysosomal enzyme α-galactosidase A, with progressive accumulation of globotriaosylceramide in multiple organs including the upper and lower airways. Objectives To assess pulmonary function at the time of the first pulmonary function test (PFT) performed among the National Danish Fabry cohort and define the prevalence of affected lung function variables. Materials and Method A cross-sectional retrospective cohort study of 86 adult patients enrolled in one or both international patient registry databases for Fabry disease, Fabry Registry or FollowME with at least one PFT. The Mainz Severity Score Index (MSSI) was calculated to determine the disease severity. Lung function variables were examined by multivariate regression adjusted for important variables for developing airway illness. Results Seventeen patients (20%) showed obstructive airflow limitation and 7 (8%) a restrictive lung deficiency. Smoking status ( p = .016) and MSSI ( p < .001) were associated with increasing obstructive airway limitation. Conclusion The prevalence of affected lung function among the National Danish Fabry cohort was 28%. Patients with classic gene variants frequently developed a decrease in lung function regardless of their smoking status, with significant relationship with disease severity.
Exploring Feminine Hygiene Product Adoption: A Gynecologists’ Perspective in India. Application of the Theory of Planned Behavior (TPB) to Women’s Buying Behavior
Authors: Shukla Smriti , Sanjeev Rinku 
Published: February 2024

Purpose Feminine hygiene has emerged as a crucial topic of concern in recent years, with growing emphasis on the perspectives of medical professionals, particularly gynecologists. This paper sets out to study the feminine hygiene product adoption among women from gynecologists’ perspective using the theory of planned behavior (TPB) as a relevant and effective framework to study the behavioral tendencies of target audience. Methods Our research employs a qualitative approach, engaging in-depth interviews with 25 gynecologists. A semi-structured questionnaire guided these interviews, and they took place in settings chosen by the gynecologists themselves, such as private clinics or hospitals. The collected data was meticulously analyzed using thematic analysis. Findings Our study confirms the applicability of the TPB as a qualitative research tool. Furthermore, the results have contributed to the evolution and enhancement of the TPB model by incorporating additional influential variables. Notably, ‘comfort’ was identified as a significant factor influencing women’s attitude towards feminine hygiene, and beyond the TPB constructs, product knowledge was revealed to play a pivotal role in shaping women’s intentions to adopt feminine hygiene products. Practical Implication From a social marketing perspective, our study offers valuable insights for various stakeholders within the healthcare industry, policymakers, and product manufacturers. It highlights the urgency of normalizing the acceptance of feminine hygiene products, addressing unfamiliar advantages and disadvantages, and promote product efficacy. By adopting these strategies, stakeholders can better cater to women’s needs and enhance their overall health and well-being. Originality/Value This research makes a noteworthy contribution to the feminine hygiene literature by shedding light on the constructs that need to be integrated to understand women’s menstrual hygiene behavior comprehensively. This study has offered a wide range of understanding about feminine hygiene phenomenon from gynecologists’ perspective that has not yet been explored in any study. Additionally, we provide a robust theoretical framework for comprehending the feminine hygiene context, offering a foundation for further research and practical interventions.
Antibacterial Activity and Possibly Made of Action of Isoquinoline-3-Carboxylic Acid
Authors: Zhiyuan Xu , Haixin Ding , Xin Fu , Yan Xu , Fadi Zhu , Huochun Ye , Yuan Yuan Zhang , Yongxia Guo , Jing Zhang , Gang Feng 
Published: February 2024

Objectives Due to the urgent need to develop innovative, environmentally sustainable bactericides, we use the natural product isoquinoline as a lead compound to discover highly active bactericides from isoquinoline derivatives. Methods In this paper, the antibacterial activity of 49 isoquinoline derivatives was evaluated against three plant bacteria in vitro. Results Among all the derivatives, isoquinoline-3-carboxylic acid (IQ3CA) demonstrated significant antibacterial activity against Ralstonia solanacearum ( Rs), Acidovorax citrulli ( Ac), X. oryzae pv. oryzicola ( Xoc), X. campestris pv. campestris ( Xcc), P. carotovorum subsp. carotovorum ( Pcc), and X. fragariae ( Xf), with EC50 values ranging from 8.38 to 17.35 μg/mL. Furthermore, IQ3CA exhibited a potent protective effect against Ac, with an efficacy of 68.56% at 200 μg/mL, which was not significantly different from that of the positive control kasugamycin (72.48%) and was superior to that of the positive control thiosen copper (64.62%). The scanning electron microscopy observations revealed that treatment of Ac cells with IQ3CA at a concentration of 25 μg/mL resulted in a curved and sunken cell morphology, along with destroyed cell membrane integrity. Additionally, the motility and exopolysaccharides production of Ac were inhibited, and biofilm formation was prevented. Conclusion These results suggest that IQ3CA holds promise as a lead compound with antibacterial properties against plant diseases.
Knowledge, attitudes, and practices of secondary school students towards COVID-19 in Sana’a City, Yemen: A cross-sectional study
Authors: Al-Shahethi Ahmed H , Alhidary Ahmed , Alrubaiee Gamil Ghaleb , Al-Shahethi Hakim M , Al-Shameri Emad A , Abol Gaith Fawz Mohammad , Ali Al-Dhahari Amar , Al-Soofi Ahmed Mohammed , Abkar Mohammed Abdo , Al-Surimi Khaled 
Published: February 2024

Background: Understanding of public awareness on public health issues is very crucial, including the current health crisis of COVID-19. This research aimed to examine the Knowledge, Attitudes and Practices among Students towards COVID-19. Design and methods: A cross-sectional survey was conducted among secondary school students in grades 10–12. Proportional sample allocation was used in 16 randomly selected schools. Moreover, the schools were recruited by using a systematic random sampling technique. Socio-demographic data and questions of the knowledge, attitude and practice were collected by interview. Logistic regression analyses were employed to identify the associated factors and p-value < 0.05 was considered statistically significant. Results: Among the 357 participants the level of good knowledge, positive attitude, and optimal practice were 65.2%, 66.7% and 89.4% respectively. Regression analyses showed that being in the adolescent age group (15–16 years old), living with >5 family size, and family with a good income effectively predicted knowledge level. Attitudes towards COVID-19, male students were pessimistic about COVID-19 prevention and control measures as opposed to their female counterparts [aOR = 0.39; 95% CI: 0.21–0.71). Students with awareness of the virus demonstrated greater (two-fold) odds of a positive attitude as opposed to their less-conscious counterparts. The urban-area male students were demonstrated a higher (three-fold) odds of good practice level towards COVID-19 prevention and control measures as opposed to their rural-area female counterparts. Conclusion: A good knowledge level denoted a positive attitude despite the lack of information. Meanwhile, good preventive measure practices and behaviours reflected high levels.
Correlation Between Improvement in Pain After Ultrasound-Guided Intra-articular Hip Injection and Outcomes After Arthroscopy in Patients With Femoroacetabular Impingement
Authors: Shuang Ya-Juan , Mao Yi , Yu Kang-Kang , Li Chun-Bao , Zhang Ming-Bo 
Published: February 2024

Background: An accurate and objective criterion is needed to determine candidates who are suitable for hip arthroscopy in patients with femoroacetabular impingement (FAI). Purpose: To determine whether improvement in pain after ultrasound (US)-guided intra-articular hip injection during standardized examinations can be used to predict the outcomes of hip arthroscopy in patients with FAI. Study Design: Cohort study; Level of evidence, 3. Methods: We enrolled 119 patients with FAI who underwent US-guided intra-articular hip injection of local anesthesia during standardized examinations, carried out from May 2018 to February 2020 (within 2 weeks before hip arthroscopy). All patients had undergone a minimum of 6 months of nonoperative treatment without remission and had 2-year follow-up data. Pain visual analog scale (VAS) scores (0-10) were recorded for 7 different physical examination tests, and a total score (0 [best] to 70 [worst]) was obtained. In addition, International Hip Outcome Tool–12 (iHOT-12) and modified Harris Hip Score (mHHS) scores were recorded before hip arthroscopy and at final follow-up. According to whether patients achieved the substantial clinical benefit (SCB) on the iHOT-12, they were divided into SCB and non-SCB groups, and the improvement in VAS pain scores from preinjection to postinjection (ΔVAS pain) was compared between the 2 groups. Logistic regression analysis was used to predict the achievement of SCB, and the area under the receiver operating characteristic curve (AUC) was used to estimate the accuracy of the prediction. Results: There was a significant pre- to postoperative increase in iHOT-12 (31.6 points; P < .001) and mHHS (20.0 points; P < .001) scores, and 84 (70.6%) patients achieved the SCB. The ΔVAS pain score was significantly greater in the SCB versus the non-SCB group (16.0 vs 7.0 points; respectively; P < .001). Logistic regression analysis demonstrated an optimal cutoff value of 8.5 points for ΔVAS pain (AUC, 0.772; 95% CI, 0.687-0.858). For patients with more severe symptoms (total preinjection VAS pain score of >10 out of 70), the accuracy of the prediction for ΔVAS pain had a better evaluation value (AUC, 0.834; 95% CI, 0.676-0.992). Conclusion: Improvement in pain after US-guided intra-articular hip injection predicted the outcomes of hip arthroscopy in patients with FAI in this study, especially for patients with more severe pain.