bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone deacetylase‐mediated silencing of PSTPIP2 expression contributes to aristolochic acid nephropathy‐induced PANoptosis
Authors: Xu Chuanting , Wang Qi , Du Changlin , Chen Lu , Zhou Zhongnan , Zhang Zhenming , Cai Na , Li Jun , Huang Cheng , Ma Taotao 
Published: December 2023

Background and PurposeAristolochic acid nephropathy (AAN) is a progressive kidney disease caused by using herbal medicines. Currently, no therapies are available to treat or prevent aristolochic acid nephropathy. Histone deacetylase (HDAC) plays a crucial role in the development and progression of renal disease. We tested whether HDAC inhibitors could prevent aristolochic acid nephropathy and determined the underlying mechanism.Experimental ApproachHDACs expression in the aristolochic acid nephropathy model was examined. The activation of PANoptosis of mouse kidney and renal tubular epithelial cell were assessed after exposure to HDAC1 and HDAC2 blockade. Kidney‐specific knock‐in of proline–serine–threonine–phosphatase‐interacting protein 2 (PSTPIP2) mice were used to investigate whether PSTPIP2 affected the production of PANoptosome.Key ResultsAristolochic acid upregulated the expression of HDAC1 and HDAC2 in the kidneys. Notably, the HDAC1 and HDAC2 specific inhibitor, romidepsin (FK228, depsipeptide), suppressed aristolochic acid‐induced kidney injury, epithelial cell pyroptosis, apoptosis and necroptosis (PANoptosis). Moreover, romidepsin upregulated PSTPIP2 in renal tubular epithelial cells, which was enhanced by aristolochic acid treatment. Conditional knock‐in of PSTPIP2 in the kidney protected against aristolochic acid nephropathy. In contrast, the knockdown of PSTPIP2 expression in PSTPIP2‐knock‐in mice restored kidney damage and PANoptosis. PSTPIP2 function was determined in vitro using PSTPIP2 knockdown or overexpression in mouse renal tubular epithelial cells (mTECs). Additionally, PSTPIP2 was found to regulate caspase 8 in aristolochic acid nephropathy.Conclusion and ImplicationsHDAC‐mediated silencing of PSTPIP2 may contribute to aristolochic acid nephropathy. Hence, HDAC1 and HDAC2 specific inhibitors or PSTPIP2 could be valuable therapeutic agents for preventing aristolochic acid nephropathy.
The efficacy of natural products for the treatment of nasopharyngeal carcinoma
Authors: Ao Xudong , Luo Chao , Zhang Mengni , Liu Lisha , Peng Shunlin 
Published: December 2023

AbstractNasopharyngeal carcinoma (NPC) is a malignant tumor originating in the nasopharyngeal epithelium with a high incidence in southern China and parts of Southeast Asia. The current treatment methods are mainly radiotherapy and chemotherapy. However, they often have side effects and are not suitable for long‐term exposure. Natural products have received more and more attention in cancer prevention and treatment because of their its high efficiency, low toxic side effects, and low toxicity. Natural products can serve as a viable alternative, and this study aimed to review the efficacy and mechanisms of natural products in the treatment of NPC by examining previous literature. Most natural products act by inhibiting cell proliferation, metastasis, inducing cell cycle arrest, and apoptosis. Although further research is needed to verify their effectiveness and safety, natural products can significantly improve the treatment of NPC.
A moderated mediation model of the relationship between adolescent screentime, online privacy cognitions and exposure to online substance marketing
Authors: Corcoran Erin , Wydra Nathaniel , Tejada Nelsa , Nelapati Shimei , Gabrielli Joy 
Published: December 2023

AbstractAdolescent exposure to substance‐related marketing is associated with subsequent substance initiation and progression. The extent to which adolescents are exposed to such content may be associated with adolescent cognitions about digital privacy and media‐specific parenting behaviours. The present study assesses whether the relationship between screentime and online marketing risk is mediated by adolescent digital privacy‐related cognitions and moderated by media‐specific parenting behaviours. Parents and their 10–14‐year‐old adolescents (n = 960) completed an online survey on media parenting techniques and adolescent media use and attitudes. Associations between screentime, Adolescent Cognitions about Online Privacy (ACOP; comprising privacy‐related attitudes, subjective norms and perceived behavioural control), TECH parenting (Talk, Educate, Co‐Use, House Rules) and adolescent online marketing exposure were explored via a moderated mediation model. A significant total effect between screentime and online marketing exposure was identified, including an indirect path via ACOP. TECH parenting significantly strengthened ACOP's mediation of the relationship between screentime and online marketing risk. This study indicates that adolescent privacy‐related cognitions may be an important mechanism for future studies related to adolescent online risk behaviour. Implications for child and family social work are discussed.
Habitat specialisation and resource availability determine dispersal behaviour in four afro‐tropical butterflies
Authors: Habel Jan Christian , Milidakis Melina A. , Lindorfer Sophia , Teucher Mike , Schmitt Thomas , Eberle Jonas 
Published: December 2023

Abstract
Ecological demands, such as sex and environmental conditions, determine species' behaviour, such as dispersal, and shape local population structures. However, only marginal knowledge of these factors exists for afro‐tropical insects so far.
Therefore, we performed a mark–release–recapture study in the coastal region of Kenya over a period of 2 months, covering the dry and the rainy seasons. As study species, we used four co‐occurring but ecologically diverging butterfly species, the forest species Bicyclus safitza and Junonia natalica and the savannah species Junonia oenone and Byblia ilithyia. The study area represents an ecosystem mosaic consisting of anthropogenic habitats as well as natural forest and savannah, assessed by detailed landscape mapping.
We obtained 1701 capture events, comprising 1224 individuals with an overall recapture rate of 24% (ranging from 15% to 48%). The analyses based on these results allowed an assessment of the population ecology, dispersal behaviour and habitat preferences of these species.
Demographic models inferred different patterns of population dynamics among species. All species preferred the habitats they were known for. The observed dispersal distances were rather low ranging from a mean of 25 to 72 m, referring to taxa and sexes. The dispersal extrapolations were unreliably low for the negative exponential function, while the values for inverse power function were credible. The latter predicted a considerably higher long‐distance dispersal capacity in males than in females of the forest species B. safitza and J. natalica, while females dispersed more than males in the savannah species J. oenone and B. ilithyia.
Our results obtained from these four ecologically diverging afro‐tropical butterfly species underline that species’ behaviour, such as dispersal, is strongly determined by habitat preferences, sex and the availability of resources.
Culinary capital and conceptualisations of school mealtime
Authors: Lalli Gurpinder Singh 
Published: December 2023

AbstractThis paper presents ethnographic work conducted to investigate how notions of culinary capital have the potential to shape the everyday experiences of children during mealtime in school. Children's early experiences with mealtimes and food are critical determinants for eating behaviour over the life course. The paper presents an account of conceptual debates based on longstanding ethnographic work on school food with a particular focus on a case study of Maple Field Academy to frame the research. Research methods used included semi‐structured interviews, fieldnotes and photographs with the aim of capturing a rich picture of the school. This paper introduces Laird's sensory theory to frame the discussion. This research calls for the need to recognise the social good that can be realised from participating in mealtimes and school is a microcosm of society, which means it can function as a driver for social change. The paper calls for more engagement with social theorising on studies which focus on researching food in school.
Personal networks and the politics of belonging: Refugee integration in Thessaloniki Greece
Authors: Bulled Nicola 
Published: December 2023

AbstractRefugees use social networks to navigate the institutions of immigration. Social networks also serve as support structures as refugees claim their identity and establish a sense of belonging. This paper examines the influence of personal social networks on the integration experiences of 16 asylum‐seekers in Thessaloniki, Greece. Case studies of three recent asylum‐seekers convey how the dynamics of personal social networks differentially influence the experiences of integration. The visualizations of their personal social network, the 45 individuals they engage with routinely, reveal the structure and composition of their social lives. Across the study sample, refugees with more Greek contacts were better able to navigate the economic and legal landscape. However, more engagement with host nationals did not necessarily improve feelings of belonging. Migration policies and programming should consider how to use social networks, both existing and new, to improve migrant integration outcomes.
Role of Laboratory in Emerging Infectious Disease Control in Iran, Pasteur Institute of Iran, and national laboratory network
Authors: Maleki Ali , Mostafavi Ehsan , Fazlalipour Mehdi , Salehi‐Vaziri Mostafa 
Published: December 2023

AbstractStrengthening surveillance systems is a key aspect of outbreak response and was particularly important during the COVID‐19 pandemic. Respiratory pathogens spread rapidly, and laboratory capacity is key to monitoring the spread. Prior to the pandemic, Iran had established a rapid response team and laboratory network to provide identification, monitoring, and detection of emerging infectious diseases, but did not have the laboratory capacity to respond to COVID‐19. Following the announcement of the COVID‐19 pandemic, the rapid response team diverted all attention to supporting COVID‐19 surveillance. Iran built on the existing national laboratory infrastructure to incorporate SARS‐CoV‐2 surveillance into the response network. Based on existing international protocols, in‐house molecular diagnosis capacity was operationalized, and commercial controls and assays were acquired and validated to national standards. The first COVID‐19 laboratory was operational by January 25, less than 4 weeks before the initial detection of SARS‐CoV‐2 was announced. Assays and support were expanded and rolled out to form the COVID‐19 National Laboratory Network, which consists of 560 multi‐sectoral laboratories covering all provinces of Iran. The national laboratory network supports a wide range of operational capacities, including assay validation and protocol development, quality assurance, respiratory pathogen diagnosis and surveillance, and variant identification and assessment using multiple sequencing platforms. This network has supported the testing of over 55 million samples over the past 36 months using RT‐qPCR and has sequenced approximately 2200 samples across the country, contributing the data to international databases, including GISAID.
The second most abundant dinophyte in the ponds of a botanical garden is a species new to science
Authors: Müller Anna , Stark Marina , Schottenhammel Sophia , John Uwe , Chacón Juliana , Klingl Andreas , Holzer Victoria Julia Christine , Schöffer Marika , Gottschling Marc 
Published: December 2023

AbstractIn the microscopy realm, a large body of dark biodiversity still awaits to be uncovered. Unarmoured dinophytes are particularly neglected here, as they only present inconspicuous traits. In a remote German locality, we collected cells, from which a monoclonal strain was established, to study morphology using light and electron microscopy and to gain DNA sequences from the rRNA operon. In parallel, we detected unicellular eukaryotes in ponds of the Botanical Garden Munich‐Nymphenburg by DNA‐metabarcoding (V4 region of the 18S rRNA gene), weekly sampled over the course of a year. Strain GeoK*077 turned out to be a new species of Borghiella with a distinct position in molecular phylogenetics and characteristic coccoid cells of ovoid shape as the most important diagnostic trait. Borghiella ovum, sp. nov., was also present in artificial ponds of the Botanical Garden and was the second most abundant dinophyte detected in the samples. More specifically, Borghiella ovum, sp. nov., shows a clear seasonality, with high frequency during winter months and complete absence during summer months. The study underlines the necessity to assess the biodiversity, particularly of the microscopy realm more ambitiously, if even common species such as formerly Borghiella ovum are yet unknown to science.
Did High Leverage Render Small Businesses Vulnerable to the COVID‐19 Shock?
Authors: BRÄUNING FALK , FILLAT JOSÉ L. , WANG J. CHRISTINA 
Published: December 2023

AbstractUsing supervisory data on small and midsized nonfinancial enterprises (SMEs), we find that those SMEs with higher leverage faced tighter constraints in accessing bank credit after the COVID‐19 outbreak in spring 2020. Specifically, SMEs with higher pre‐COVID leverage obtained a smaller volume of new loans and had to pay a higher spread on them during the pandemic period. Consistent with an inward shift in loan supply, these effects were concentrated in loans originated by banks with below‐median capital buffers. Highly levered SMEs that relied on low‐capital large banks for funding before the pandemic were not able to substitute to other sources of debt financing and thus experienced more of a reduction in total debt as well as a decline in investment and employment. On the other hand, the unprecedented public support, especially the Paycheck Protection Program (PPP), mitigated the adverse real effect stemming from bank credit constraints.
Psychological distress and coping efficacy in children with disorders of gut–brain interaction
Authors: Santucci Neha R. , Velasco‐Benitez Carlos Alberto , Cunningham Natoshia , Li Jesse , Fei Lin , Sun Qin , Saps Miguel 
Published: December 2023

AbstractBackgroundMultiple psychological factors influence disorders of gut–brain interaction (DGBIs). We aimed to evaluate psychological distress in Colombian schoolchildren with and without DGBIs.MethodsWe included children ages 8–18 years without organic medical conditions from largest regional public schools in Colombia. Children completed Spanish versions of Rome III diagnostic questionnaire for DGBIs, State Trait Anxiety Inventory for Children (STAIC), Children's Somatization Inventory (CSI), and a measure of coping efficacy. These data, demographic and socioeconomic characteristics, were compared between children with DGBIs and healthy peers. Exploratory analyses investigated differences between youth with symptoms of functional abdominal pain disorders (FAPDs) compared with healthy peers.Key ResultsOf 1496 children, 281 (mean age 12.9 ± 2.2 years, 49.8% females) self‐reported criteria for DGBIs and 125 reported (44.5%) FAPDs. Children with DGBIs had higher trait anxiety, emotional sensitivity, somatization including GI, non‐GI, pain‐related, and non‐pain‐related subscales (p < 0.001 each) and lower coping efficacy (p = 0.02) compared to healthy peers. Females had higher trait anxiety and somatization (p = 0.04 and p = 0.005, respectively). State and trait anxiety and coping efficacy differed based on location in children with DGBIs (p = 0.02, p = 0.03, and p < 0.001, respectively). Children with FAPDs had higher trait anxiety (p = 0.02) and somatization (p < 0.001) compared to healthy youth.Conclusions & InferencesChildren with DGBIs had higher anxiety, emotional sensitivity, and somatization, and lower coping efficacy compared with healthy youth. This highlights the importance of appraising psychological distress characteristics as well as incorporating conflict resolution, assertiveness training, and resilience building during the treatment of DGBIs.
Genomic imprints of unparalleled growth
Authors: Murik Omer , Geffen Or , Shotland Yoram , Fernandez‐Pozo Noe , Ullrich Kristian Karsten , Walther Dirk , Rensing Stefan Andreas , Treves Haim 
Published: December 2023

Summary

Chlorella ohadii was isolated from desert biological soil crusts, one of the harshest habitats on Earth, and is emerging as an exciting new green model for studying growth, photosynthesis and metabolism under a wide range of conditions.

Here, we compared the genome of C. ohadii, the fastest growing alga on record, to that of other green algae, to reveal the genomic imprints empowering its unparalleled growth rate and resistance to various stressors, including extreme illumination. This included the genome of its close relative, but slower growing and photodamage sensitive, C. sorokiniana UTEX 1663.

A larger number of ribosome‐encoding genes, high intron abundance, increased codon bias and unique genes potentially involved in metabolic flexibility and resistance to photodamage are all consistent with the faster growth of C. ohadii. Some of these characteristics highlight general trends in Chlorophyta and Chlorella spp. evolution, and others open new broad avenues for mechanistic exploration of their relationship with growth.

This work entails a unique case study for the genomic adaptations and costs of exceptionally fast growth and sheds light on the genomic signatures of fast growth in photosynthetic cells. It also provides an important resource for future studies leveraging the unique properties of C. ohadii for photosynthesis and stress response research alongside their utilization for synthetic biology and biotechnology aims.
The effect of body mass index on complications in cardiac implantable electronic device surgery
Authors: Güzel Tuncay , Demir Muhammed , Aktan Adem , Kılıç Raif , Arslan Bayram , Günlü Serhat , Altıntaş Bernas , Karahan Mehmet Zülküf , Özbek Mehmet , Aslan Burhan , Arpa Abdulkadir , Coşkun Mehmet Sait , Altunbaş Mahsum , Tüzün Rohat , Akgümüş Alkame , Karadeniz Muhammed , Aydın Saadet , Güzel Hamdullah , Aslan Selen Filiz , Söner Serdar , Taş Ahmet , Ertaş Faruk 
Published: December 2023

AbstractBackgroundCardiac implantable electronic device (CIED) procedures are prone to complications. In our study, we investigated the effect of body mass index (BMI) on CIED‐related complications.Methods1676 patients who had undergone CIED surgery (de novo implantation, system upgrade, generator change, pocket revision or lead replacement) at two heart centers in Turkey and met the study criteria were included in our study. For analysis of primary and secondary endpoints, patients were classified as non‐obese (BMI < 25 kg/m2), overweight (25 ≤ BMI < 30 kg/m2), and obese (BMI ≥ 30 kg/m2). The primary endpoint was accepted as cumulative events, including the composite of clinically significant hematoma (CSH), pericardial effusion or tamponade, pneumothorax, and infection related to the device system. Secondary outcomes included each component of cumulative events.ResultsThe rate of cumulative events, defined as primary outcome, was higher in the obese patient group, and we found a significant difference between the groups (3.0%, 4.3%, 8.9%, p = .001). CSH and pneumothorax rates were significantly higher in the obese patient group (0.3%, 0.9%, 1.9%, p = .04; 1.0%, 1.4%, 3.3%, p = .04, respectively). According to our multivariate model analysis; gender (OR:1.882, 95%CI:1.156–3.064, p = .01), hypertension (OR:4.768, 95%CI:2.470–9.204, p < .001), BMI (OR:1.069, 95%CI:1.012–1.129, p = .01) were independent predictors of cumulative events rates.ConclusionsPeriprocedural complications associated with CIED (especially hematoma and pneumothorax) are more common in the group with high BMI.
Learning point cloud context information based on 3D transformer for more accurate and efficient classification
Authors: Chen Yiping , Zhang Shuai , Lin Weisheng , Zhang Shuhang , Zhang Wuming 
Published: December 2023

AbstractThe point cloud semantic understanding task has made remarkable progress along with the development of 3D deep learning. However, aggregating spatial information to improve the local feature learning capability of the network remains a major challenge. Many methods have been used for improving local information learning, such as constructing a multi‐area structure for capturing different area information. However, it will lose some local information due to the independent learning point feature. To solve this problem, a new network is proposed that considers the importance of the differences between points in the neighbourhood. Capturing local feature information can be enhanced by highlighting the different feature importance of the point cloud in the neighbourhood. First, T‐Net is constructed to learn the point cloud transformation matrix for point cloud disorder. Second, transformer is used to improve the problem of local information loss due to the independence of each point in the neighbourhood. The experimental results show that 92.2% accuracy overall was achieved on the ModelNet40 dataset and 93.8% accuracy overall was achieved on the ModelNet10 dataset.
Corruption, patronage, and avertable child deaths in developing countries
Authors: Hiroi Taeko , Schober Gregory S. 
Published: December 2023

AbstractMany children die of easily preventable or treatable diseases in developing countries. What are the relationships between corruption, patronage, and child mortality in low‐ and middle‐income countries? We argue that corruption and patronage affect child mortality outcomes for some causes of death, especially those that are more easily prevented or treated with affordable care. To test our hypotheses, we utilize cross‐national time‐series analysis of under‐five child mortality in developing countries between 1996 and 2016. Our study finds that patronage and corruption increase under‐five child mortality arising from easily preventable childhood diseases, but they have almost no effect on under‐five child mortality caused by more complex illnesses. Our study underscores the need to examine cause‐specific health outcomes rather than overall health outcomes in comparative health analysis, as the ability of governments to address specific health issues depends on the nature of the problems.Related ArticlesIreni‐Saban, Liza. 2013. “Give Me Children or Else I Die: The Politics and Policy of Cross‐Border Reproductive Care.”Politics & Policy41(1): 5–38.https://doi.org/10.1111/polp.12004.Lagunes, Paul F. 2012. “Corruption's Challenge to Democracy: A Review of the Issues.”Politics & Policy40(5): 802–26.https://doi.org/10.1111/j.1747‐1346.2012.00384.x.Tusalem, Rollin F. 2022. “Does Gendered Representation in National Legislatures Promote Substantive Representation and Human Development? Evidence from the Developing World.”Politics & Policy50(6): 1096–137.https://doi.org/10.1111/polp.12503.