bluuebunny/crossref_metadata_2025_split huggingface dataset:
An image inpainting-based data augmentation method for improved sclerosed glomerular identification performance with the segmentation model EfficientNetB3-Unet
Authors: He Songping , Zou Yi , Li Bin , Peng Fangyu , Lu Xia , Guo Hui , Tan Xin , Chen Yanyan 
Published: January 2024

AbstractThe percent global glomerulosclerosis is a key factor in determining the outcome of renal transfer surgery. At present, the rate is typically computed by pathologists, which is labour intensive and nonstandardized. With the development of Deep Learning (DL), DL-based segmentation models can be used to better identify and segment normal and sclerosed glomeruli. Based on this, we can better quantify percent global glomerulosclerosis to reduce the discard rate of donor kidneys. We used 51 whole slide images (WSIs) from different institutions that are publicly available on the internet. However, the number of sclerosed glomeruli is much smaller than that of normal glomeruli in different WSIs, which can reduce the effectiveness of Deep Learning. For better sclerosed glomerular identification and segmentation performance, we modified and trained a GAN (generative adversarial network)-based image inpainting model to obtain more synthetic sclerosed glomeruli. Our proposed inpainting method achieved an average SSIM (Structural Similarity) of 0.8086 and an average PSNR (Peak Signal-to-Noise Ratio) of 22.8943 dB in the area of generated sclerosed glomeruli. We obtained sclerosed glomerular segmentation performance improvement by adding synthetic sclerosed glomerular images and achieved the best Dice of glomerular segmentation in different test sets based on the modified Unet model.
Coronavirus takeover of host cell translation and intracellular antiviral response: a molecular perspective
Authors: Karousis Evangelos D , Schubert Katharina , Ban Nenad 
Published: January 2024

AbstractCoronaviruses are a group of related RNA viruses that cause respiratory diseases in humans and animals. Understanding the mechanisms of translation regulation during coronaviral infections is critical for developing antiviral therapies and preventing viral spread. Translation of the viral single-stranded RNA genome in the host cell cytoplasm is an essential step in the life cycle of coronaviruses, which affects the cellular mRNA translation landscape in many ways. Here we discuss various viral strategies of translation control, including how members of the Betacoronavirus genus shut down host cell translation and suppress host innate immune functions, as well as the role of the viral non-structural protein 1 (Nsp1) in the process. We also outline the fate of viral RNA, considering stress response mechanisms triggered in infected cells, and describe how unique viral RNA features contribute to programmed ribosomal −1 frameshifting, RNA editing, and translation shutdown evasion.
Bat algorithm based semi‐distributed resource allocation in ultra‐dense networks
Authors: Fan Yaozong , Ma Yu , Pan Peng , Yang Can 
Published: January 2024

AbstractThis paper addresses the resource allocation (RA) for ultra‐dense network (UDN), where base stations (BSs) are densely deployed to meet the demands of future wireless communications. However, the design of RA in UDN is challenging, as the RA problem is non‐convex and NP‐hard. Therefore, this paper considers and studies a semi‐distributed resource block (RB) allocation scheme, in order to achieve a well‐balanced trade‐off between performance and complexity. In the context of semi‐distributed RB allocation scheme, the problem can be decomposed into the subproblem of clustering and the subproblem of cluster‐based RB allocation. We first improve the K‐means clustering algorithm by employing the Gaussian modified method, which can significantly decrease the number of iterations for carrying out the K‐means algorithm as well as the failure possibility of clustering. Then, bat algorithm (BA) is introduced to attack the problem of cluster‐based RB allocation. In order to make the original BA applicable to the problem of RB allocation, chaotic sequences are adopted to discretize the initial position of the bats, and simultaneously increase the population diversity of the bats. Furthermore, in order to speed up the convergence of BA, the logarithmic decreasing inertia weight is employed for improving the original BA. Our studies and performance results show that the proposed approaches are capable of achieving a desirable trade‐off between the performance and the implementation complexity.
Tangent barrier Lyapunov function based adaptive event‐triggered control for CPS under false data injection attacks
Authors: Miao Baoling , Zeng Qiang , Liu Lei 
Published: January 2024

AbstractIn this paper, an adaptive event‐triggered control scheme is proposed for a class of continuous‐time linear cyber‐physical systems (CPSs) with unknown false data injection attacks (FDIA) and state constraints. First, the adaptive boundary estimation mechanism and Nussbaum‐type function are introduced into the two‐step backstepping control, which successfully reduces the impact of unknown attack gain. Second, considering that the Nussbaum function causes the chattering problem of the system state, the Tangent Barrier Lyapunov function (TBLF) is used to constrain the state. Then, the controller is designed in combination with the event‐triggered mechanism (ETM), which saves communication resources. Based on the designed adaptive event‐triggered security control method, all signals of the closed‐loop system can be guaranteed to be bounded, and the state constraints are not violated. Finally, the simulation results verify the effectiveness and rationality of the proposed control strategy.
Hydrogen, the new green energy resource
Authors: Grecea Danut , Csaszar Tiberiu , Pupazan Gabriela , Nicola Aurelian 
Published: January 2024

The desire to reduce pollution and price instability generated by the major share of fossil fuel use requires firm solutions for green transition of economy, that must provide access to clean, safe and affordable energy. An important sector, seriously affected, being a competitive field with consistent limitations, is the transport system, where use of alternative fuels, the hydrogen, is perhaps a solution.
Hydrogen can be used as a raw material, fuel, and can be stored with many other possible uses in industry sectors, not only transportation. Most importantly, it does not emit CO2 and almost does not pollute the air when in use. It therefore provides a solution for decarbonising industrial processes and economic sectors where carbon reduction is both urgent and difficult to achieve. All this makes hydrogen essential to support the EU's commitment to climate neutrality, on the one hand, and to global effort to implement the Paris Agreement, on the other.
The present paper presents all aspects, through simulation in MATLAB-Simulink, of the production, storage and use of hydrogen as an alternative fuel source.
Time evolution of sulphur dioxide concentration generated by solid fuel combustion systems during the cold periods of the year
Authors: Kovacs Marius , Toth Lorand , Vlad Lăutaru 
Published: January 2024

About 99% of sulphur dioxide present in the atmosphere comes from anthropogenic activities, the main source being industrial activity that processes sulphur materials, including burning fuels (coal, oil or gas), thus releasing sulphur dioxide into the air.
The purpose of this paper is to monitor the concentration of sulphur dioxide during two seasons, in the ambient air of Petroșani, with the aim of highlighting the possible atmospheric pollution caused by thermal power plants that use solid fuel during the winter period.
The monitoring periods were distributed over a period of 6 months (three in summer and three in winter), namely the summer months (May, June, July of 2022), the winter months of December (2022), January and February of 2023.
The main objective of the measurements is to identify if there is an increase in sulphur dioxide concentration in the atmosphere, resulting from the burning of solid fuels from household activities during the winter period.
Results indicate that there is a higher degree of SO2 pollution in the winter period, but the recorded values are far below the limits set by national legislation. The paper presents some measures to limit sulphur dioxide pollution in the context of climate change.
Endoscopic ultrasound for structured surveillance after curative treatment of esophageal cancer
Authors: Bohle Wolfram , Nowack Lioba , Schaudt Andre , Koeninger Joerg , Zoller Wolfram G. , Albert Jörg G. 
Published: January 2024

Abstract
Background Structured surveillance after treatment of esophageal cancer is not established. Due to a paucity of data, no agreement exists on how surveillance should be performed. The main argument against intensive follow-up in esophageal cancer is that it may not lead to true survival advantage.
Methods Structured surveillance was performed in 42 patients after multimodal therapy with peri-operative chemotherapy (29) or definitive chemoradiotherapy (13) of esophageal cancer. The surveillance protocol included gastroscopy, endoscopic ultrasound, chest X-ray, abdominal ultrasound, and CEA measurement at regular intervals of up to five years. We analyzed relapse rate, time to relapse, localization of recurrence, diagnosis within or without structured surveillance, diagnostic method providing the first evidence of a relapse, treatment of recurrence, and outcome.
Results Median follow-up was 48 months; 18/42 patients suffered from tumor relapse, with 16 asymptomatic patients diagnosed within structured surveillance. Median time to recurrence was 9 months. Isolated local or locoregional recurrence occurred in 6, and isolated distant relapse in 9 patients. All patients with isolated locoregional recurrence were exclusively diagnosed with endoscopic ultrasound. Six patients received curatively intended therapy with surgery or chemoradiation, leading to long-lasting survival.
Conclusion Structured surveillance offers the chance to identify limited and asymptomatic tumor relapse. Especially in cases of locoregional recurrence, long-lasting survival or even a cure can be achieved. Endoscopic ultrasound is the best method for the detection of locoregional tumor recurrence and should be an integral part of structured surveillance after curative treatment of esophageal cancer.
Does Age Influence Gastrointestinal Status Responses to
Exertional-heat Stress?
Authors: Young Pascale , Henningsen Kayla , Snipe Rhiannon , Gaskell Stephanie , Alcock Rebekah , Mika Alice , Rauch Christopher , Costa Ricardo J. S. 
Published: January 2024

AbstractThis meta-data exploration aimed to determine the impact of exertional-heat
stress (EHS) on gastrointestinal status of masters age and young adult endurance
athletes. Sixteen MASTERS (mean: 44y) and twenty-one YOUNG (26y) recreational
endurance athletes completed 2 h of running at 60%
˙V O2max in 35˚C ambient
conditions. Blood samples were collected pre-, immediately and 1 h post-EHS, and
analyzed for markers of exercise-induced gastrointestinal syndrome (EIGS).
Thermo-physiological measures and gastrointestinal symptoms (GIS) were recorded
every 10–20 min during EHS. Peak Δ pre- to post-EHS did not
substantially differ (p>0.05) between MASTERS and YOUNG for intestinal
epithelial injury [I-FABP: 1652pg/ml vs. 1524pg/ml,
respectively], bacterial endotoxic translocation [sCD14:
-0.09µg/mL vs. 0.84µg/mL, respectively],
lipopolysaccharide-binding protein [LBP: 0.26µg/mL vs.
1.76µg/mL, respectively], and systemic inflammatory response
profile (SIR-Profile: 92.0arb.unit vs. 154arb.unit, respectively). A
significantly higher peak Δ pre- to post-EHS in endogenous endotoxin
anti-body IgM (p=0.042), and pro-inflammatory cytokine IL-1β
(p=0.038), was observed in YOUNG compared to MASTERS. No difference was
observed between incidence (81% and 80%, respectively) and
severity (summative accumulation: 21 and 30, respectively) of reported GIS
during EHS between MASTERS and YOUNG. Pathophysiology of EIGS in response to EHS
does not substantially differ with age progression, since masters and younger
adult endurance athletes responded comparably.
Living-Donor Liver Transplantation for a Large Hepatocellular Carcinoma in a Genetically Identical Twin Sister
Authors: Koek Ger , Schmitz Sophia M. , Bednarsch Jan , Heise Daniel , Longerich Thomas , Bakers Frank , Trautwein Christian , Luedde Tom , Ulmer Tom Florian , Neumann Ulf Peter 
Published: January 2024

AbstractHepatocellular carcinoma (HCC) is, to date, the most common malignant tumor of the liver and is commonly staged with the Milan criteria. While deceased-donor liver transplantations (DDLT) are reserved for patients within the Milan criteria, living-donor liver transplantation (LDLT) might be a curative option for patients outside the Milan criteria. We here report a case of a 32-year-old woman who developed a giant, unresectable HCC out of a hepatocellular adenoma (HCA) after a pregnancy. The genetically identical twin sister donated her left hemi-liver after ethical approval and preoperative screening. No long-term immunosuppressive therapy was necessary, and after more than eight years, both are in perfect health and the recipient gave birth to a second child. This case shows that in certain situations large HCCs outside the standard criteria can be cured by LT. Careful evaluation of both donor and recipient should be performed for indications like this to assure optimal clinical outcome.
Full trisomy 14 in one of bichorionic biamniotic
twins
Authors: Habek Dubravko , Cerovac Anis 
Published: January 2024

Case presentationWe describe the case of the lethal full trisomy (T) 14 in a fetus from bichorionic
biamniotic (BCBA) twin pregnancy. This is a case of a 28-year-old primigravida, with
an unremarkable personal and family history, who just like her 30-year-old husband,
was without consanguinity between spouses. She conceived spontaneously, without a
burdened gynecological-obstetric history. By the 12th week of pregnancy, she had
hyperemesis gravidarum and one episode of bleeding due to which progesterone
supplementation was prescribed. Due to asymptomatic bacteriuria, she took cefuroxime
axetil in the 13th week of pregnancy and azithromycin in the 15th week due to
cervicitis with ureaplasma urealyticum.
Liver transplantation meets gastrointestinal cancer
Authors: Loosen Sven H. , Leyh Catherine , Neumann Ulf Peter , Bock Hans , Weigel Christian , Luedde Tom , Roderburg Christoph 
Published: January 2024

AbstractLiver transplantation (LT) has emerged as a standard of care for patients with end-stage liver disease, providing a life-saving intervention for patients with severely compromised liver function in both the acute and chronic setting. While LT has also become a routine procedure for early-stage hepatocellular carcinoma (HCC), offering a potential cure by treating both the tumor and the underlying liver disease, its relevance in the context of other malignancies such as cholangiocellular carcinoma (CCA), combined hepatocellular-cholangiocarcinoma (cHCC-CCA) or liver metastases is still the subject of intense debate and no definite recommendations have yet been established. This review summarizes the current therapeutic standards in the context of LT for gastrointestinal malignancies and provides a reflection and outlook on current scientific and clinical developments.
Liver transplantation for HCC in cirrhosis: Are Milan criteria outdated?
Authors: Linecker Michael , Braun Felix , Gundlach Jan-Paul , Ellrichmann Mark , van Rosmalen Marieke , Vogelaar Serge , Eimer Christine , Rheinbay Corinna , Rösgen Sabina , Schäfer Jost-Philipp , Becker Thomas 
Published: January 2024

AbstractIn Germany, organ allocation is based on the MELD-system and lab-MELD is usually low in patients with hepatocellular carcinoma (HCC) in cirrhosis. Higher medical urgency can be achieved by standard exception for HCC (SE-HCC), if Milan criteria (MC) are met. Noteworthy, UNOS T2 reflects MC, but excludes singular lesions < 2 cm. Thus, SE-HCC is awarded to patients with one lesion between 2 and 5 cm or 2 to 3 lesions between 1 and 3 cm. These criteria are static and do not reflect biological properties of HCC.We present a retrospective cohort of 111 patients, who underwent liver transplantation at UKSH, Campus Kiel between 2007 and 2017. No difference was found in overall survival for patient cohorts using Milan, UCSF, up-to-seven, and French-AFP criteria. However, there was a significantly reduced survival, if microvascular invasion was detected in the explanted organ and in patients with HCC-recurrence. The exclusive use of static selection criteria including MC appear to limit the access to liver transplantation.
Overview: Chronic Pain and Cannabis-Based Medicines
Authors: Karst Matthias 
Published: January 2024

AbstractChronic pain is primarily conceptualized as a disease in its own right when it is
associated with emotional distress and functional impairment.
Pathophysiologically, dysfunction of the cortico-mesolimbic connectome is of
major importance, with overlapping signals in the nociceptive and stress
systems. The endocannabinoid system plays an important role in the central
processing of nociceptive signals and regulates the central stress response.
Clinically, there is moderate evidence that cannabis-based medicines (CBM) can
contribute to a significant reduction in pain, especially the associated pain
affect, and improvement in physical function and sleep quality in a proportion
of patients with chronic pain. The analgesic effect appears to be largely
independent of the cause of pain. In this context, CBM preferentially regulates
stress-associated pain processing.
Ocular Trauma Characterization in a Reference Emergency Eye Centre in Colombia (FOSCAL)
Authors: Pedraza-Concha Angelica , Tello Alejandro , Diaz Alberto Luis , Díaz-Martínez Luis Alfonso , Ortiz Rafael , Galvis Virgilio 
Published: January 2024

Abstract
Background Ocular trauma is one of the most important causes of ocular morbidity and inadequate visual acuity in developed and developing countries. In some countries, eye trauma is the leading cause of monocular blindness. Studies conducted in developing countries like Colombia suggest that there is a lack of awareness of preventive measures. In Colombia, there is no countrywide ocular trauma registry. The purpose of the present study is to describe and analyse characteristics of ocular trauma at a tertiary ophthalmology emergency department in Colombia.
Patients/Methods and Material Patients who consulted or were referred to the ophthalmologic emergency department of FOSCAL due to eye injuries between March 1, 2022, and January 10, 2023, were included in this cross-sectional study.
Results Of 1 957 patients, 2 088 eyes were included. Men comprised 78.5% of the patients, the median age was 36 years, and 75.0% lived in urban areas. The median latency between trauma and ophthalmology consultation was 21.8 hours. Of the eyes, 1 805 (88.4%) had suffered mechanical or mixed (mechanical plus burn) trauma. Of the injuries, 87.5% were unilateral. In terms of the circumstances, 45.9% of injuries occurred during working or educational activities (in 85.6% of these cases, without eye protection), 28.2% in home accidents, and 14.0% in transportation situations. According to the Birmingham Eye Trauma Terminology System (BETT), 1 735 eyes (91.1%) were closed globe injuries, and 49 eyes (2.7%) were open globe injuries. Fifty eyes (2.8%) could not be categorised according to BETT at the initial consultation and were classified as “still to be determined”. In the Ocular Trauma Score (OTS), 85.8% were category 5. Of the ocular burn cases, 93.0% were categorised as
grade I according to the Roper Hall classification.
Conclusions In line with global literature, a much higher proportion of men than women sought consultation for ocular trauma. The findings suggest a need for improvement in the referral process from institutions with the lowest level of care. Lack of awareness about eye protection is an issue. Surgical exploration or additional tests may be necessary for precise injury classification. We therefore propose adding a “still to be determined” category to the BETT initial classification. These cases may be reclassified later, thus improving the accuracy of OTS calculation.
Association of Red Blood Cell and Platelet Parameters with Metabolic
Syndrome: A Systematic Review and Meta-Analysis of 170,000
Patients
Authors: Mahmood Aysal , Samad Saba , Haider Hoorain , Hassan Wardah , Mushtaq Rabeea , Perwaiz Aimen , Ali Abraish , Azharuddin Muhammad 
Published: January 2024

AbstractThis systematic review and meta-analysis aim to establish associations between
metabolic syndrome (MetS) and erythrocyte and platelet markers, contributing to
improved diagnostic tests for identifying individuals at risk. Observational
studies and Randomized Controlled Trials (RCTs) were included. The standardized
mean difference (SMD) and 95% confidence intervals (CI) of erythrocyte
and platelet markers between individuals with and without MetS were used as
effect size (inverse variance model). Methodological quality assessment was
conducted using the Newcastle-Ottawa scale (NOS) for observational studies and
the Cochrane Risk of Bias tool 2.0 for RCTs. The analysis included 51 articles.
Compared to controls, individuals with MetS exhibited significantly higher
concentrations of mean red blood cell count [Standardized Mean Difference
(95% CI): 0.15 (0.13−0.18); p<0.00001], hemoglobin [0.24
(0.18−0.31); p<0.00001], blood platelet count [5.49
(2.78–8.20); p<0.0001], and red blood cell distribution width
[(0.55 (0.05–1.04); p=0.03]. Regarding mean platelet volume
[0.16 (– 0.03 to 0.35); p=0.10] and
platelet-to-lymphocyte ratio (PLR) [7.48 (–2.85–17.81);
p=0.16], a non-significant difference was observed in patients with
MetS. There was no statistically significant difference in hematocrit counts
between the two groups [0.47 (–0.40 to –1.34); p=0.29].
Biomarkers such as mean red blood cell count, hemoglobin, blood platelet count,
and RDW are associated with higher levels in patients in MetS, whereas mean
platelet volume and PLR tend to be lower. These markers can potentially provide
new avenues for early diagnosis of MetS.
Esterification as a Demonstration of Electrochemically Powered Catalytic Dehydration
Authors: Nacsa Eric D. , Haines Christopher A. , Han Jian 
Published: January 2024

AbstractThe reliance on wasteful stoichiometric reagents to accomplish dehydration reactions such as esterification, amidation, and alcohol substitution is a longstanding challenge in synthetic chemistry. To address this problem, an electrochemical approach has been developed as a new conceptual platform for dehydration reactions. As a proof-of-concept demonstration, an electrochemical esterification protocol has been described that proceeds at room temperature, without acid or base additives, and without consuming stoichiometric reagents. This approach therefore overcomes key complications of esterification chemistry, and we envision that it will similarly enable improvements to a range of important, related transformations.1	Introduction2	An Electrochemical Design for Catalytic Dehydration3	Electrochemical Esterification4	Conclusions