bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green preparation of metal–organic frameworks in deep eutectic systems with boosted photocatalytic activity
Authors: Jiang Wenqian , Chen Yumei , Ding Xinru , Bi Wentao 
Published: January 2025

AbstractBackgroundMetal–organic frameworks (MOFs) are known for their extensive specific surface area, robust stability, and diverse active sites, which make them highly effective for applications in photocatalysis. The deep eutectic system (DESys) offers a green alternative to traditional toxic organic solvents and can impart novel, eco‐friendly properties to synthesized materials. This study investigates DESys/MIL‐100(Fe), a MOF synthesized within a DESys, and its application for the photocatalytic decomposition of tetracycline hydrochloride (TC‐HCl). Compared to conventional synthesis methods, the DESys‐based approach avoids the use of toxic hydrofluoric acid and high‐pressure reaction equipment, making it more environmentally friendly and potentially suitable for large‐scale industrial production of MOFs.ResultsThe results showed that DESys/MIL‐100(Fe) demonstrated significantly better photocatalytic performance for TC‐HCl degradation than the traditional MIL‐100(Fe) synthesized by conventional methods. After 2 h of visible‐light exposure, the decomposition efficiency of TC‐HCl reached 91.20% with DESys/MIL‐100(Fe), while it was only 38.74% with MIL‐100(Fe) under identical conditions. The improved performance of DESys/MIL‐100(Fe) can be attributed to its enhanced adsorption capabilities, increased number of active sites, greater absorption of visible light, and higher carrier density. These factors contribute to its superior catalytic efficiency.ConclusionThe findings demonstrate that DESys/MIL‐100(Fe) not only exhibits outstanding stability and catalytic performance in the degradation of pollutants but also highlights the potential of using DESys for the green synthesis of high‐performance MOFs. This approach offers a sustainable pathway for the large‐scale production of MOFs with superior photocatalytic properties for environmental applications. © 2025 Society of Chemical Industry (SCI).
Mental health and treatment use in undergraduate engineering students: A comparative analysis to students in other academic fields of study
Authors: Whitwer Matthew D. , Wilson Sarah A. , Hammer Joseph H. , Gomer Brenna 
Published: January 2025

AbstractBackgroundEngineering students experience high levels of distress and low rates of mental health treatment seeking, yet there is a gap in knowledge around how this compares with that of students in other fields of study. Given the influence of social identity (e.g., gender identity, race/ethnicity) on mental health and treatment seeking, it is important to account for sociodemographic variation across fields when performing such comparisons.PurposeThis study used Andersen's Behavioral Model to compare mental health distress and treatment use between students in engineering and other fields while controlling for sociodemographic factors.MethodsSurvey data came from the 2021–2022 Healthy Minds Study (N > 50,000). Measures related to mental health, treatment use, and diagnosis were examined. Descriptive statistics were determined for each field of study, and regression analyses were used to assess differences across fields while accounting for covariates.ResultsCompared to students from other fields, engineering students were among the least likely to report symptoms of depression and anxiety. However, 44.4% of undergraduate engineering students screened positive for current depression and/or anxiety. Of those who screened positive, only 40.4% had received therapy/counseling in the past year. Further, they were the least likely to have received a depression or anxiety diagnosis when compared to students from other fields.ConclusionWhen controlling for sociodemographic factors, undergraduate engineering students reported lower rates of mental health distress and treatment use compared to students in other fields. This study highlights the need for considering engineering culture in the interpretation of student mental health and treatment.
Protocol for Oligonucleotides Characterization Using Hydrophilic Interaction Chromatography
Authors: Guillarme Davy , Fekete Szabolcs , Studzińska Sylwia 
Published: January 2025

ABSTRACTOligonucleotides (ONs) are an increasingly popular category of molecules in the pharmaceutical landscape, particularly attractive for the treatment of genetic and rare diseases. However, analyzing these molecules presents significant challenges, due to their highly hydrophilic nature, multiple negative charges, and the presence of closely related impurities resulting from the complex solid‐phase synthesis process. Ion pairing reverse‐phase liquid chromatography (IP‐RPLC) is the preferred technique for ONs analysis but is not ideal for mass spectrometry (MS) coupling. Consequently, there is a growing interest in exploring alternative strategies with hydrophilic interaction chromatography (HILIC) emerging as one of the most promising options. As HILIC is not yet fully established for the analysis of ONs, we have prepared this protocol paper to facilitate entry into this field. It not only provides best practices, opportunities, and potential advantages but also caveats and other important considerations for using HILIC to characterize ONs. The paper addresses the selection of stationary and mobile phases, optimization of gradient conditions, MS coupling, and key aspects to consider when manipulating ON samples. We hope this protocol will help establish HILIC as a more universal solution for ONs analysis.
Lingual Artery Identification for Ligation in Neck Dissection and Transoral Surgery for Oropharyngeal Tumors
Authors: Chia Clemente , Sharp Samuel , Zhang Henry , Magarey Matthew J.R. 
Published: January 2025

ObjectivesTransoral robotic surgery (TORS) and transoral laser microsurgery (TOLM) plus neck dissection are viable alternatives to radiotherapy as a treatment modality in select cases of oropharyngeal squamous cell carcinoma. Many centers advocate for elective ligation of the feeding arteries at index neck dissection prior to TORS/TOLM to mitigate the risk of catastrophic perioperative hemorrhage. Although there are multiple cadaveric studies in the literature to identify the lingual artery at multiple points throughout its course, there are no studies on the intraoperative identification of the lingual artery for elective ligation prior to TORS/TOLM.MethodsA retrospective review of all patients undergoing neck dissection with vessel ligation prior to TORS. Lingual artery was identified at its origin, and relation to hypoglossal nerve was recorded. Patient demographics, intraoperative findings including the relation between lingual artery and hypoglossal nerve measured in millimeters, and postoperative complications were extracted from medical records.ResultsOf the 33 cases eligible for this study, the lingual artery was identified directly deep to the hypoglossal nerve in 21 cases (63.6%). Of the remaining cases, seven were within 5 mm inferior to the hypoglossal nerve (21.2%), and only two cases (6.1%) were identified superior to the hypoglossal nerve.ConclusionThe hypoglossal nerve is a useful landmark for the intraoperative identification of the lingual nerve in elective neck dissection prior to TORS. The lingual artery can be identified either immediately deep to or within 5 mm inferior to the hypoglossal nerve in majority of cases.Level of Evidence4 Laryngoscope, 2025
Conductive Open‐Cell Silicone Foam for Tunable Damping and Impact Sensing Application
Authors: Preuer Rene , Sleichrt Jan , Kytyr Daniel , Lindner Philip , Cakmak Umut , Graz Ingrid 
Published: January 2025

AbstractNature has long served as a source of inspiration for the development of new materials, with foam‐like structures in citrus fruits such as oranges and pomelos serving as examples of efficient energy dissipation. Inspired by the internal structure of citrus fruit, soft conductive silicone foams are fabricated. The foams are made from a polydimethylsiloxane (PDMS) by mold casting using sugar templates. Addition of silicone oil and carbon black to the silicone allows creation of extremely soft foams that serve as resistive sensor. Completed by a pneumatic radial compression actuator (PRCA) surrounding the foams like a ring in analogy to citrus fruit peel, smart tunable dampers with sensing capabilities are demonstrated. The foams are evaluated for their electrical and mechanical properties alone as well as in conjunction with the PRCA. When pressurized, the PRCA radially compresses the smart foams, allowing to tune their stiffness and thus damping properties. Tunability of this system is evaluated by means of ball drop tests with respect to damping as well as the sensor performance regarding its sensitivity and stability. Overall, the study provides valuable insights into the behavior of conductive silicone foams and their potential as cushioning and impact sensing material.
Professional Learning in a Web‐Based Community of Practice Of, By, and For Chinese Primary Science Teachers: A Narrative Inquiry
Authors: Jin Xiaowan , Tang Xiaowei , Yu Bojun , Li Zuomin , Chen Jianqiu , Zhu Zuanbiao , Zhu Bin , Chen Meijuan , Ding Bangping 
Published: January 2025

ABSTRACTThis study examines Chinese primary science teachers' professional learning experience in a web‐based community of practice established and run by practitioners, with support from teacher researchers. Over time, it has grown into a preferred knowledge‐sharing base for primary science teachers of the region and gradually gained national recognition. Through narrative inquiry, we reconstruct a story that shows how the community emerged and developed into a way of empowering Chinese primary science teachers in their own professional development. Adopting the community of practice framework (Wenger 1998) and with attention guided by the metaphorical space of temporality, sociality, and place, our analysis brings out how the external contexts, the organizational features, and the teachers' learning practices intertwined and contribute to the long‐lasting success of this community. Some of the key organizational features we identify go beyond the ones stressed by the existing literature. More importantly, we show the critical role external contexts can play in the working mechanism of a web‐based community. On that basis, we suggested the need to enrich the methodological choices and broaden the scope of this line of research.
Elements of Social Capital and Counterspace Processes Contribute to Undergraduate STEM Student Development of a Sense of Belonging
Authors: Gray MacKenzie J. , Yacobian Jasmine N. , Shortlidge Erin E. 
Published: January 2025

ABSTRACTHaving a sense of belonging can promote persistence in the STEM fields, but less is known about what it means to develop that sense of belonging. To investigate this phenomenon, we conducted semi‐structured interviews with a cohort of STEM students (n = 10) nearing graduation at an urban university regarding their sense of belonging and qualitatively coded the interviews using thematic analysis. Results revealed that all interviewed students clearly articulated feelings of belonging, making them an ideal population from which to learn more. We applied two frameworks to guide our understanding of what factors promoted the development of a sense of belonging for these students: the Network Theory of Social Capital and the Counterspaces Framework. The students described their experiences in relation to elements of social capital and counterspace processes as they reflected on the development of feelings of belonging. One element of social capital, “reinforcement,” or assurance and recognition of one's worthiness as a member of a group, was the most prevalent element of social capital influencing the participants' development of a sense of belonging. “Direct relational transactions,” or the exchange of resources within a community, was the most prevalent counterspace process discussed by the participants. Our findings expand the utility and add to the theoretical underpinnings of the two frameworks, indicating that gaining social capital and experiencing counterspaces can contribute to undergraduate STEM student development of a sense of belonging.
Enantioselective Catalytic Synthesis of Inherently Chiral Calixarenes
Authors: Qin Wenling , Cera Gianpiero 
Published: January 2025

AbstractSince the introduction of the concept of inherent chirality by Böhmer, an important part of research focused on the asymmetric synthesis of calixarene macrocycles. However, long synthetic procedures and tedious separation strategies hampered the application of this technology in many topics of organic chemistry, including enantioselective molecular recognition and catalysis. Very recently, a new generation of enantioselective catalytic methodologies has been reported, able to provide highly functionalized, inherently chiral calixarenes in a straightforward manner. In this review, we will discuss these new catalytic methods and the versatile properties of such macrocycles that call for potential applications in many areas of science.
The Role of Environmental Factors Prior to Diagnosis on the Activity and Severity of Inflammatory Bowel Diseases—Results From the Prospective Population‐Based Copenhagen Inflammatory Bowel Disease Inception Cohort
Authors: Attauabi Mohamed , Madsen Gorm Roager , Bendtsen Flemming , Burisch Johan , Seidelin Jakob Benedict 
Published: January 2025

ABSTRACTBackgroundThe influence of environmental factors on the severity of early inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is unclear. Herein, we aimed to investigate the role of environmental factors in the initial phenotype, activity, and severity of IBD.MethodsCopenhagen IBD Inception Cohort is a prospective population‐based cohort of patients with newly diagnosed IBD between May 2021 and May 2023. Data on environmental factors were captured at IBD diagnosis using International Organisation of IBD (IOIBD) and HeartDiet questionnaires. Environmental factors' influence on outcome was analyzed and odds ratios (aOR) were adjusted for age, gender, and disease characteristics (adjusted OR, aOR [95% confidence interval]).ResultsIn total, 208 and 128 patients with incident UC and CD, respectively, were included. Active smoking was associated with increased risk of CD‐related hospitalization (aOR = 2.84 [1.03; 7.88]) and stricturing phenotype (aOR = 5.28 [1.76; 15.85]) but lower risk of severe UC course (aOR = 0.28 [0.08; 0.95]). Further, previous smoking was not associated with negative effects in patients with CD in terms of early need for biologics, surgery, or hospitalization. In terms of diets, daily consumption of fruits (aOR = 0.27 [0.07; 0.99]) or vegetables (aOR = 0.27 [0.09; 0.80]) was inversely associated with stricturing CD, whereas whole meal bread was associated with reduced risk of severe CD activity (aOR = 0.40 [0.16; 0.98]).ConclusionsThis prospective population‐based study highlighted several environmental factors associated with the initial severity and activity of IBD, emphasizing their pivotal role in the initial disease burden and giving guidance to personalized patient counseling.
Inadequate Therapy Response on Advanced Therapy in Ulcerative Colitis Adult Patients: A Retrospective Analysis of German Health Claims Data
Authors: Dignass Axel , Blumenstein Irina , Schwedhelm Carolina , Strassen Katrin , Kunk Leonie , Marquardt Sophie , Seiffert Anna , Kulchytska Nataliia , Hänsel Ivonne , Benson Alexa , Kisser Agnes 
Published: January 2025

ABSTRACTBackgroundThe treatment landscape for active ulcerative colitis is rapidly evolving and current real‐world evidence on response to advanced therapy is limited. This study aimed to determine indicators of inadequate therapeutic response among patients with ulcerative colitis in Germany initiating advanced therapy.MethodsThis retrospective analysis used German claims data (2015–2022) from adult patients (≥ 18 years). The prevalence and incidence of ulcerative colitis (ICD‐10‐GM: K51.X) were estimated. Inadequate response to therapy was evaluated in patients initiating advanced therapy based on eight predefined indicators observed for 12 months following dispensation of index treatment.ResultsMean ulcerative colitis patient age in 2016–2022 ranged from 49.6 to 51.5 years, 47.6%–48.3% were female. Administrative prevalence ranged from 0.45% in 2016 to 0.53% in 2022. The number of patients initiating advanced treatment ranged from 157 to 347 across the study years (3.2%–4.9% of overall treated study population). On average from 2016–2021, 78.8% had inadequate response in the 12 months following index treatment. Common indicators included prolonged use of corticosteroids (46.2%) and augmentation with conventional therapies (43.9%).ConclusionsAdult ulcerative colitis patients showed a high prevalence of inadequate response to advanced therapies. Our findings reveal a need for improved UC advanced therapy options, providing insight into inadequate response patterns. This may help identify patients who could benefit from a change in therapy to improve long‐term outcomes.
Sterile pyogranulomatous pericarditis in a dog
Authors: Reguera Burgos Pablo , Mesa Sánchez Ignacio , Martínez Gil Carlos 
Published: January 2025

AbstractA 4‐year‐old, neutered, female crossbreed dog was presented with a chronic history of weakness and hyperthermia. Echocardiography showed mild pericardial effusion. Fluid analysis revealed a marked non‐septic neutrophilic‐macrophagic exudate. Pericardial fluid and blood culture were negative. Leishmania spp., Ehrlichia spp., Bartonella spp., Babesia spp., Mycoplasma spp. and Hepatozoon spp. reverse transcription polymerase chain reaction tests were also negative. Initially, a good response to pericardiocentesis, empirical antibiotic therapy and prednisone was observed. However, pericardial effusion recurred and a subtotal pericardiectomy was performed. Histopathology of the pericardial tissue showed a severe pyogranulomatous inflammatory process. Periodic acid–Schiff and Ziehl–Neelsen stains, pericardial tissue culture and fluorescence in situ hybridisation were negative. Clinical signs recurred, and prednisone was prescribed again. Twenty‐two months after prednisone withdrawal, the dog remains asymptomatic. This is the second report of idiopathic sterile pyogranulomatous pericarditis in a dog, and the first report using fluorescence in situ hybridisation to evaluate the presence of bacterial pericarditis.
Epicardial Pacemaker Lead Related Cardiac Strangulation: The Importance of Early Recognition
Authors: Kendall Scott , Agouba Rihab , Murray Jane , Morrison Margaret Louise , McCrossan Brian , Grant Brian , Sands Andrew , Casey Frank , Nolke Lars 
Published: January 2025

Abstract
Lead strangulation is a dangerous complication of epicardial pacemaker insertion. This complication has been increasingly highlighted lately. Our institution has recently identified four cases over the past five years. This study’s aim was to 1) identify risk factors for strangulation and 2) prospectively screen existing epicardial pacemaker patients for unrecognized strangulation or features that would prompt closer review. Patients known to the pacemaker clinic with epicardial pacemakers inserted from 2005 to 2023 were included. Electronic health records were used to locate all subjects and gather data. Risk factors were identified using Firth’s penalized method of logistic regression. Forty-five patients were included, of which four (8.8%) had evidence of strangulation. Posterior–anterior (PA) chest radiographs all demonstrated characteristic looping patterns of the pacing leads, with confirmation on CT angiography. All affected patients underwent revision surgery. Implantation at a weight of less than 6.5 kg was associated with a significantly increased incidence of strangulation (OR 25, P 0.044). Other factors including lead length, presence of structural cardiac disease, and dual-chamber insertion were not statistically significant. No patients who were prospectively screened were found to have strangulation. Children undergoing insertion of a pacemaker early in infancy are at particularly high risk of strangulation and should be closely monitored following surgery. Regular chest radiography (every three years) to screen for this complication is advised. Larger multi-center studies to pool data for this relatively rare complication may help identify other risk factors for strangulation.
Eco-friendly zinc oxide nanoparticle biosynthesis powered by probiotic bacteria
Authors: AL-Tameemi Ahmed Issa , Masarudin Mas Jaffri , Rahim Raha Abdul , Mizzi Rachel , Timms Verlaine J. , Isa Nurulfiza mat , Neilan Brett A. 
Published: January 2025

Abstract
The rapid advancement of nanotechnology, particularly in the realm of pharmaceutical sciences, has significantly transformed the potential for treating life-threatening diseases. A pivotal aspect of this evolution is the emergence of “green nanotechnology,” which emphasizes the environmentally sustainable synthesis of raw materials through biological processes. This review focuses on the biological synthesis and application of zinc oxide (ZnO) nanoparticles (NPs) from probiotic bacteria, particularly those sourced from wastewater. Microorganisms from wastewater tolerate harmful elements and enzymatically convert toxic heavy metals into eco-friendly materials. These probiotic bacteria are instrumental in the synthesis of ZnO NPs and exhibit remarkable antimicrobial properties with diverse industrial applications. As the challenge of drug-resistant pathogens escalates, innovative strategies for combating microbial infections are essential. This review explores the intersection of nanotechnology, microbiology, and antibacterial resistance, highlighting the importance of selecting suitable probiotic bacteria for synthesizing ZnO NPs with potent antibacterial activity. Additionally, the review addresses the biofunctionalization of NPs and their applications in environmental remediation and therapeutic innovations, including wound healing, antibacterial, and anticancer treatments. Eco-friendly NP synthesis relies on the identification of these suitable microbial “nano-factories.” Targeting probiotic bacteria from wastewater can uncover new microbial NP synthesis capabilities, advancing environmentally friendly NP production methods.

Key points

• Innovative strategies are needed to combat drug-resistant pathogens like MRSA.

• Wastewater-derived probiotic bacteria are an eco-friendly method for ZnO synthesis.

• ZnO NPs show significant antimicrobial activity against various pathogens.