bluuebunny/crossref_metadata_2025_split huggingface dataset:
Summary of the Clinical Practice Guidelines for Upper Tract Urothelial Carcinoma 2023 by the Japanese Urological Association
Authors: Mori Kazuyuki , Hatakeyama Shingo , Enokida Hideki , Miyake Hideaki , Kikuchi Eiji , Nishiyama Hiroyuki , Ichikawa Tomohiko , Kamai Takao , Kaji Yasushi , Kume Haruki , Kondo Tsunenori , Matsuyama Hideyasu , Masumori Naoya , Kawauchi Akihiro , Takenaka Atsushi , Uemura Hirotsugu , Eto Masatoshi , Nonomura Norio , Fujii Yasuhisa , Hinotsu Shiro , Ohyama Chikara 
Published: December 2023

AbstractThis article is an English translation of the Clinical Practice Guidelines for Upper Tract Urothelial Carcinoma (2nd edition) published in June 2023. The Japanese Urological Association's (JUA) Guidelines Committee on Upper Tract Urothelial Carcinoma (UTUC) created a 2023 update guideline to support clinicians' current evidence‐based management of UTUC and to incorporate its recommendations into clinical practice. The new guideline adhered as closely as possible to the Minds Manual for Guideline Development 2020 ver. 3.0. Findings related to epidemiological, pathological, diagnosis, treatment, and follow‐up were reviewed. In addition, seven clinical questions (CQs) were set to determine the grade of recommendation and level of evidence. Preconceptions and biases were removed from the preparation process, the overall evidence was evaluated appropriately, and recommendations were made after fully considering the balance between benefits and harms. Although the evidence is still insufficient to be taken up as a CQ, the latest important information is described in seven columns, and clinical issues that should be resolved in the future related to the CQ are described as recommendations for tomorrow. We hope that these guidelines will help medical professionals, patients, and their families involved in the treatment of UTUC in their decision‐making, and hope that a critical review of these guidelines will lead to further refinements in the next edition.
Fe3O4/C@SiC nanocomposite microwave absorbing material derived from MIL‐101(Fe)@SiC
Authors: Wei Mengjia , Wang Lei , Rehman Sajjad Ur , Zhang Wenmiao , Shen Shuqi , Peng Biyun , Hu Yifeng , Liang Tongxiang 
Published: December 2023

AbstractThe Fe3O4/C@SiC nanocomposites were synthesized by pyrolyzing MIL‐101(Fe)@SiC nanocomposites under Ar gas atmosphere. The magnetic Fe3O4 enhances the magnetic loss of the composite material, while the abundant defects and voids on the surface of MIL‐101(Fe)‐derived porous carbon form a network with SiC whiskers, extending the transmission path of electromagnetic waves. The synergistic effect of Fe3O4 and porous carbon optimizes the impedance matching of the material and improves its attenuation capability. As a result, the Fe3O4/C@SiC nanocomposite exhibits excellent microwave absorption performance. Fe3O4/C@SiC nanocomposites about minimal reflection loss (RLmin) of −80.11 dB at 5.93 GHz and an effective absorption bandwidth (RL −10 dB) of 3.57 GHz (4.33–7.90 GHz). The findings of this study shed light on the potential of SiC for microwave absorption applications.
Type 1 diabetes and the risk of epilepsy: A meta‐analysis
Authors: Wu Shuhui , Ding Yanan 
Published: December 2023

ABSTRACTAims/IntroductionAn overrepresentation of epilepsy has been suggested in patients with type 1 diabetes (T1D). This meta‐analysis was conducted to evaluate if type 1 diabetes is associated with a higher incidence of epilepsy.Materials and MethodsLongitudinal observational studies which are relevant to the purpose of the meta‐analysis were screened and obtained by searching PubMed, Embase, and Web of Science databases. Random‐effects models were used when significant heterogeneity was observed; otherwise, fixed‐effects models were used.ResultsSix observational studies involving 10 datasets of 8,001,899 participants were included, with six datasets including children and only one dataset including older people. Among them, 100,414 (1.25%) had type 1 diabetes. During the follow‐up duration of 5.4–15.2 years (mean: 9.5 years), 98,644 cases (1.23%) of epilepsy were observed. Compared with participants with normoglycemia, those with type 1 diabetes were shown to have a higher incidence of epilepsy (risk ratio [RR]: 2.41, 95% confidence interval 1.69–3.44, P < 0.001; I2 = 95%) after adjustment of potential confounding variables including age and sex. Subgroup analysis showed consistent results in nested case–control and retrospective cohort studies, and in studies of children, non‐elderly adult, and older participants (P for subgroup difference = 0.42 and 0.07). In addition, a stronger association of type 1 diabetes and epilepsy was suggested in studies with follow‐up duration <10 years compared with those ≥10 years (RR: 3.34 vs 1.61, P for subgroup difference < 0.001).ConclusionPatients with type 1 diabetes may have a higher risk of epilepsy, which was mainly driven by datasets including children.
Moisture dependent physical, mechanical, and aerodynamic properties of Simarouba glauca seed: A potential tree born oilseed
Authors: Satpathy S. K. , Naik S. N. , Jena Sujata 
Published: December 2023

AbstractThe present study investigates the moisture dependence of the physical, mechanical and aerodynamic properties of Simarouba seeds within the moisture range of 9.24‐22.46% d.b. The length, width and thickness significantly increased from 19.43 to 22.71 mm, 11.52 to 13.88 mm and 9.79 to 11.34 mm respectively. Our findings showed significant effect of moisture content on the one thousand unit mass, bulk density, true density, and porosity which varied in the range of 1050.41g and 1204.7g, 638.88 to 503.88 kg∙m−3, 999.57 to 970.26 kg∙m−3 and 36.08% to 48.06%. Moisture content was found to have positive effect on the angle of repose terminal velocity and static coefficient of friction for all surfaces studied. A decreasing trend in rupture force and increasing trend in deformation with moisture content was also observed. The understanding of these properties as per the present study would be useful for designing post‐harvest processing equipment and storage of Simarouba seeds.Practical applicationsSimarouba glauca, D.C. is an evergreen potential tree born oilseed tree with high scope for biodiesel and edible oil production. The oilseed is presently underutilized due to lack of availability of suitable processing equipment. The findings of the study provide a comprehensive design database related to engineering properties of Simarouba seeds. The predictive models developed in this study can be used to assess the seed properties at any given moisture content range. The enrichment of database would serve as a guide for agricultural engineers, and food processors in the design and development of relevant post‐harvest handling, and processing equipment for Simarouba seeds. This may further lead to promotion of Simarouba processing as a promising enterprise in rural India.
The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study
Authors: Zou Long , Mo Shengwei , Jia Congwei , Pang Junyi , Chang Xiaoyan , Chen Jie 
Published: December 2023

AbstractBackground and AimPancreatic intraductal papillary mucinous neoplasm (IPMN) is one of the most common precancerous lesions of pancreatic carcinoma. Studies have found that the tumoral microbiome has an important influence on pancreatic carcinoma. However, the tumoral microbiome of IPMNs has rarely been explored.MethodsTumoral microbiome gene sequencing was carried out using 16 specimens of IPMN and 45 specimens of IPMN with associated invasive carcinoma (IPMN‐IC) by 2bRAD sequencing for microbiome. The profile of the tumoral microbiome was summarized. Associations of the tumoral microbiome with disease grade, histological subtype, and prognosis were analyzed.ResultsA total of 598 species of microbes were identified, comprising 228 genera, 109 families, 60 orders, 29 classes, 14 phyla, and 2 kingdoms. The genus Pseudomonas was detected more frequently and had higher relative abundance in IPMN‐ICs; Alcaligenes faecalis was detected with higher relative abundance in IPMNs. Bifidobacterium pseudolongum had a higher relative abundance in the IPMN‐IC group, regardless of histological subtype. Moreover, among patients with IPMN‐ICs, those with a high relative abundance of B. pseudolongum had better overall survival than those with a low relative abundance. Patients who were positive for Staphylococcus aureus or Mycolicibacillus koreensis had shorter survival. The presence of S. aureus was an independent risk factor for poor prognosis.ConclusionsThere are enriching tumoral microbes in IPMN. The tumoral microbiome of IPMN is different from that of IPMN‐IC.
Assessing the rate of non‐linkage to care and identifying barriers in individuals living with hepatitis B. Results of the LINK‐B study
Authors: Feliu‐Prius Anna , Barreira‐Díaz Ana , Rando Ariadna , Vargas‐Accarino Elena , Palom Adriana , Vico‐Romero Judit , Ruiz‐Cobo Juan C. , Riveiro‐Barciela Mar , Rodriguez‐Frias Francisco , Esteban Rafael , Buti Maria 
Published: December 2023

AbstractBackground & AimsHepatitis B infection is the most frequent cause of chronic hepatitis and liver cancer worldwide. Active searching for individuals with chronic hepatitis B has been proposed as a strategy to achieve the elimination of this virus. The primary aim of this study was to link to specialists HBsAg‐positive individuals detected in a laboratory database and to characterize individuals who were not linked to care.MethodsWe performed a retrospective–prospective evaluation of all HBsAg‐positive serum samples identified in the central laboratory of the Northern Barcelona area between January 2018 and June 2022. After reviewing the patients' clinical charts, all those not linked to care were given an appointment with a specialist.ResultsMedical records of 2765 different HBsAg‐positive serum samples were reviewed and 2590 individuals were identified: 844 (32.6%) were not linked to a specialist, 653 were candidates for linkage, and 344 attended the specialist visit. The two main reasons why they were not under specialist care were administrative issues, such as living in another region (12.1%) and lacking contact details (4.1%), and low life expectancy (2.8%). Individuals who did not attend their scheduled visit were mainly young [38.1 ± 12.9 vs. 44.0 ± 14.0 (p < .001)], non‐White European [75.3% vs. 58.1% (p < .001)] and men [70.7% vs. 56.4% (p < .001)].ConclusionsOne in every three HBsAg‐positive individuals in our setting was not currently under specialist care. Of particular note, half of them had never attended a specialist consultation, an essential step for evaluating the disease and starting therapy in some countries.
The role of the gastrointestinal barrier in obesity‐associated systemic inflammation
Authors: Acciarino Adriana , Diwakarla Shanti , Handreck Jessica , Bergola Cedrick , Sahakian Lauren , McQuade Rachel M. 
Published: December 2023

SummarySystemic inflammation is a key contributor to the onset and progression of several obesity‐associated diseases and is thought to predominantly arise from the hyperplasia and hypertrophy of white adipose tissue. However, a growing body of works suggests that early changes in the gastrointestinal (GI) barrier may contribute to both local, within the GI lining, and systemic inflammation in obesity. Intestinal barrier dysfunction is well‐characterized in inflammatory GI disorders such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and is known to contribute to systemic inflammation. Thus, drawing parallels between GI disorders, where intestinal permeability and systemic inflammation are prominent features, and obesity‐induced GI manifestations may provide insights into the potential role of the intestinal barrier in systemic inflammation in obesity. This review summarizes the current literature surrounding intestinal barrier dysfunction in obesity and explores the potential role of intestinal hyperpermeability and intestinal barrier dysfunction in the development of systemic inflammation and GI dysfunction in obesity.
A Novel Technique of Arthroscopic‐Assisted Four‐Corner Fusion and Robot‐Assisted Fixation for Scaphoid Nonunion Advanced Collapse Wrist: A Single Case Study
Authors: Gao XingShuai , Lim Rebecca Qian Ru , Liu Bo 
Published: December 2023

ObjectiveScaphoid nonunion advanced collapse (SNAC) is a relatively common and debilitating wrist disorder yet its treatment remains challenging and controversial. We aim to describe a novel technique of a dual arthroscopic and robotic assisted four‐corner fusion (4CF) in the treatment of SNAC wrist.MethodsIn this study, we describe an original arthroscopic and robotic assisted 4CF, which is novel and currently unpublished in literature. The surgical approach included these predefined steps: arthroscopic resection of the scaphoid, radial styloid and of diseased cartilage between the capitate‐lunate joint and triquetrum‐hamate joint, correction of Dorsal Intercalated Segment Instability (DISI) deformity of the wrist and robotic assisted 4CF performed percutaneously with screws. Dynamic fluoroscopic imaging with the mini C‐arm was performed five times and the 3D scanning machine was used once.ResultsOur patient with SNAC II wrist was 57 years old at the time of initial presentation with a history of untreated traumatic wrist injury approximately 20 years ago. Regular wrist X‐rays were performed at the outpatient setting and a computed tomography (CT) of the wrist was performed at the third postoperative month to confirm bony union. The patient's wrist range of motion (ROM), grip strength, Visual Analog Scale (VAS) score, Quick Disabilities of Arm, Shoulder, and Hand (QuickDASH) score, Modified Mayo Wrist Score (MMWS), and Patient Rated Wrist Evaluation (PRWE) were also evaluated during short‐term follow‐up at 6 months. During the patient's review at 6 months, his VAS score was 0 with complete pain relief. His wrist flexion was 20° and wrist extension at 45°. His pronation‐supination was normal and comparable to his uninjured contralateral wrist. His operated wrist which was also his dominant hand had a grip strength of 22 kg as compared with 28 kg of the unaffected hand. He also had a Mayo Wrist Score of 85, QuickDASH score of 2.3 and PRWE of 6, and resumed his occupation as a clerk at 3 months.ConclusionsThis dual arthroscopic and robotic assisted 4CF is a novel surgical method worth considering in the treatment of SNAC II wrists. It is minimally invasive and allows for accurate placement of the screws in a single attempt. There was bony union by the third postoperative month as confirmed by CT imaging and excellent resolution of symptoms.
Percutaneous Fully‐endoscopic Anterior Transcorporeal Procedure for the Treatment of Isolated Ossification of the Posterior Longitudinal Ligament in the Cervical Spine: A Case Report
Authors: Li Jin , Ao Jun , Hu Xiaolin , Du Qian , Qin Jianpu , Ji Wen Jun , Xin Zhijun , Liao Wenbo 
Published: December 2023

BackgroundWith the development of spinal endoscopic techniques, on the basis of our previous experience in treating various types of cervical disc herniation with this endoscopic technique, we took the lead in applying the percutaneous fully endoscopic anterior transcorporeal procedure to be utilized in the treatment of the isolated cervical ossification of the posterior longitudinal ligament (OPLL).Case PresentationA 66‐year‐old male patient who weighed 57 kg, with a height of 169 cm was admitted to the hospital on September 16, 2021 because of recurrent pain and numbness in the neck, shoulder, and right arm for 2 years, which as aggravated for the last 2 weeks. Two years ago, the patient developed neck and shoulder pain accompanied by right arm pain without obvious predisposing factors, and numbness in the first web space of the right hand. In the last 2 weeks, he had difficulty moving the right arm, but no pain or numbness in the contralateral arm. MRI and CT scans demonstrated that the ossified posterior longitudinal ligament of the cervical 5/6 vertebrae with spinal canal stenosis and seriously compressed the spinal cord patient was treated with a percutaneous fully endoscopic anterior transcorporeal procedure.ConclusionOur percutaneous fully endoscopic anterior transcorporeal procedure is a feasible, minimally invasive surgery for treating isolated ossification of the posterior longitudinal ligament in the cervical spine.
Fertility in a Pandemic: Evidence from California
Authors: Nobles Jenna , Gemmill Alison , Hwang Sungsik , Torche Florencia 
Published: December 2023

AbstractThe COVID‐19 pandemic was accompanied by social and economic changes previously associated with fertility delay and reduction, sparking widespread discussion of a “baby bust” in the United States. We examine fertility trends using restricted vital statistics data from California, a diverse population of 40 million, contributing 12 percent of U.S. births. Using time series models that account for longer‐run fertility trends, we observe modest, short‐term reductions in births from mid‐2020 through early 2021. Birth counts in subsequent months matched or even eased the pace of fertility decline since the 2008 recession and are unlikely a function of the pandemic alone. Responses to the pandemic were heterogeneous. Fertility declined markedly among the foreign‐born population, largely driven by changes in net migration. Among the U.S.‐born population, the short‐term pandemic‐attributable reductions were largest among older, highly educated people, suggesting mechanisms of fertility reduction disparately accessible to those with the most resources. We find no evidence of a strong population fertility response to the pandemic's accompanying employment shock, providing additional evidence of a growing divide between macroeconomic conditions and fertility patterns in the United States.
The synergy of halotolerant PGPB and mauran mitigates salt stress in tomato (Solanum lycopersicum) via osmoprotectants accumulation
Authors: Sánchez Patricia , Castro‐Cegrí Alejandro , Sierra Sandra , Garrido Dolores , Llamas Inmaculada , Sampedro Inmaculada , Palma Francisco 
Published: December 2023

AbstractSalinity stress is one of the major abiotic factors limiting sustainable agriculture. Halotolerant plant growth‐promoting bacteria (PGPB) increased salt stress tolerance in plants, but the mechanisms underlying the tolerance are poorly understood. This study investigated the PGP activity of four halotolerant bacteria under salinity stress and the tomato salt‐tolerance mechanisms induced by the synergy of these bacteria with the exopolysaccharide (EPS) mauran. All PGPB tested in this study were able to offer a significant improvement of tomato plant biomass under salinity stress; Peribacillus castrilensis N3 being the most efficient one. Tomato plants treated with N3 and the EPS mauran showed greater tolerance to NaCl than the treatment in the absence of EPS and PGPB. The synergy of N3 with mauran confers salt stress tolerance in tomato plants by increasing sodium transporter genes' expression and osmoprotectant content, including soluble sugars, polyols, proline, GABA, phenols and the polyamine putrescine. These osmolytes together with the induction of sodium transporter genes increase the osmotic adjustment capacity to resist water loss and maintain ionic homeostasis. These findings suggest that the synergy of the halotolerant bacterium N3 and the EPS mauran could enhance tomato plant growth by mitigating salt stress and could have great potential as an inductor of salinity tolerance in the agriculture sector.
Genetic basis of maize stalk strength decoded via linkage and association mapping
Authors: Zhao Binghao , Li Kun , Wang Min , Liu Zhiyuan , Yin Pengfei , Wang Weidong , Li Zhigang , Li Xiaowei , Zhang Lili , Han Yingjia , Li Jiansheng , Yang Xiaohong 
Published: December 2023

SUMMARYStalk lodging is a severe problem that limits maize production worldwide, although little attention has been given to its genetic basis. Here we measured rind penetrometer resistance (RPR), an effective index for stalk lodging, in a multi‐parent population of 1948 recombinant inbred lines (RILs) and an association population of 508 inbred lines (AMP508). Linkage and association mapping identified 53 and 29 single quantitative trait loci (QTLs) and 50 and 19 pairs of epistatic interactions for RPR in the multi‐parent population and AMP508 population, respectively. Phenotypic variation explained by all identified epistatic QTLs (up to ~5%) was much less than that explained by all single additive QTLs (up to ~33% in the multi‐parent population and ~ 60% in the AMP508 population). Among all detected QTLs, only eight single QTLs explained >10% of phenotypic variation in single RIL populations. Alleles that increased RPR were enriched in tropical/subtropical (TST) groups from the AMP508 population. Based on genome‐wide association studies in both populations, we identified 137 candidate genes affecting RPR, which were assigned to multiple biological processes, such as the biosynthesis of cell wall components. Sixty‐six candidate genes were cross‐validated by multiple methods or populations. Most importantly, 23 candidate genes were upregulated or downregulated in high‐RPR lines relative to low‐RPR lines, supporting the associations between candidate genes and RPR. These findings reveal the complex nature of the genetic basis underlying RPR and provide loci or candidate genes for developing elite varieties that are resistant to stalk lodging via molecular breeding.
Increasing deletion sizes and the efficiency of CRISPR/Cas9‐mediated mutagenesis by SunTag‐mediated TREX1 recruitment
Authors: Capdeville Niklas , Schindele Patrick , Puchta Holger 
Published: December 2023

SUMMARYPreviously, it has been shown that mutagenesis frequencies can be improved by directly fusing the human exonuclease TREX2 to Cas9, resulting in a strong increase in the frequency of smaller deletions at the cut site. Here, we demonstrate that, by using the SunTag system for recruitment of TREX2, the mutagenesis efficiency can be doubled in comparison to the direct fusion in Arabidopsis thaliana. Therefore, we also tested the efficiency of the system for targeted deletion formation by recruiting two other 3′‐5′ exonucleases, namely the human TREX1 and E. coli ExoI. It turns out that SunTag‐mediated recruitment of TREX1 not only improved the general mutation induction efficiency slightly in comparison to TREX2, but that, more importantly, the mean size of the induced deletions was also enhanced, mainly via an increase of deletions of 25 bp or more. EcExoI also yielded a higher amount of larger deletions. However, only in the case of TREX1 and TREX2, the effect was predominately SunTag‐dependent, indicating efficient target‐specific recruitment. Using SunTag‐mediated TREX1 recruitment at other genomic sites, we were able to obtain similar deletion patterns. Thus, we were able to develop an attractive novel editing tool that is especially useful for obtaining deletions in the range from 20 to 40 bp around the cut site. Such sizes are often required for the manipulation of cis‐regulatory elements. This feature is closing an existing gap as previous approaches, based on single nucleases or paired nickases or nucleases, resulted in either shorter or longer deletions, respectively.