bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflamed immune phenotype predicts favorable clinical outcomes of immune checkpoint inhibitor therapy across multiple cancer types
Authors: Shen Jeanne , Choi Yoon-La , Lee Taebum , Kim Hyojin , Chae Young Kwang , Dulken Ben W , Bogdan Stephanie , Huang Maggie , Fisher George A , Park Sehhoon , Lee Se-Hoon , Hwang Jun-Eul , Chung Jin-Haeng , Kim Leeseul , Song Heon , Pereira Sergio , Shin Seunghwan , Lim Yoojoo , Ahn Chang Ho , Kim Seulki , Oum Chiyoon , Kim Sukjun , Park Gahee , Song Sanghoon , Jung Wonkyung , Kim Seokhwi , Bang Yung-Jue , Mok Tony S K , Ali Siraj M. , Ock Chan-Young 
Published: February 2024

BackgroundThe inflamed immune phenotype (IIP), defined by enrichment of tumor-infiltrating lymphocytes (TILs) within intratumoral areas, is a promising tumor-agnostic biomarker of response to immune checkpoint inhibitor (ICI) therapy. However, it is challenging to define the IIP in an objective and reproducible manner during manual histopathologic examination. Here, we investigate artificial intelligence (AI)-based immune phenotypes capable of predicting ICI clinical outcomes in multiple solid tumor types.MethodsLunit SCOPE IO is a deep learning model which determines the immune phenotype of the tumor microenvironment based on TIL analysis. We evaluated the correlation between the IIP and ICI treatment outcomes in terms of objective response rates (ORR), progression-free survival (PFS), and overall survival (OS) in a cohort of 1,806 ICI-treated patients representing over 27 solid tumor types retrospectively collected from multiple institutions.ResultsWe observed an overall IIP prevalence of 35.2% and significantly more favorable ORRs (26.3% vs 15.8%), PFS (median 5.3 vs 3.1 months, HR 0.68, 95% CI 0.61 to 0.76), and OS (median 25.3 vs 13.6 months, HR 0.66, 95% CI 0.57 to 0.75) after ICI therapy in IIP compared with non-IIP patients, respectively (p<0.001 for all comparisons). On subgroup analysis, the IIP was generally prognostic of favorable PFS across major patient subgroups, with the exception of the microsatellite unstable/mismatch repair deficient subgroup.ConclusionThe AI-based IIP may represent a practical, affordable, clinically actionable, and tumor-agnostic biomarker prognostic of ICI therapy response across diverse tumor types.
Investigating colossal thermal expansion driven by chalcogen bonds using AB(XCN)4 (A = Co, Zn, Cd; B = Cd, Hg; X = S, Se) compounds
Authors: Williams-Sekiguchi Robby Y. , Karpiuk Thomas E. , Leznoff Daniel B. 
Published: February 2024

The thermal expansion of eight compounds from the well-known AB(XCN)4 family of thiocyanate- and selenocyanate-bridged frameworks (A = Co, Zn, Cd; B = Cd, Hg; X = S, Se) has been studied using single-crystal X-ray crystallography and Raman spectroscopy, to investigate the influence of chalcogen bonding interactions. In the case of ZnHg(SCN)4, biaxial negative thermal expansion (−6.9(9) ppm K−1) along the a and b axes was observed, occurring elastically due to the colossal positive thermal expansion (124.3(18) ppm K−1) along the c axis driven by weak S···S interactions. Substituting the thiocyanate groups with selenocyanate groups, i.e., with ZnHg(SeCN)4, caused a decrease in the anisotropic behaviour, due to stronger Se···Se interactions suppressing the expansion (α a = −0.4(15) ppm K−1; α c = 90.0(17) ppm K−1). Replacing Zn with Cd was found to also suppress the anisotropic behaviour—regardless of the chalcogen used—while placing Cd at the B site enhanced the anisotropic behaviour. The effect of replacing Zn with Co was less clear, likely due to their similar size. Overall, the results illustrate how weak chalcogen bonds can drive colossal thermal expansion, leading to biaxial negative or zero thermal expansion.
Seasonal changes in the ventilatory response to hypoxia in migratory sparrows and an introduced resident sparrow
Authors: Mohns Maggie L. , Guglielmo Christopher G. , Ivy Catherine M. 
Published: February 2024

Recent research has shown that songbirds that reside at low altitudes can ascend to ∼6000 m above sea level during migratory flight. Since migratory flight is aerobically demanding, whether migratory songbirds exhibit plasticity in breathing to maintain oxygen uptake in low-oxygen environments is unknown. This study investigated whether the hypoxic ventilatory response of sparrows was altered between resident house sparrows ( Passer domesticus (Linneaus, 1758)) and migratory song sparrows ( Melospiza melodia (A. Wilson, 1810)), and Lincoln's sparrows ( Melospiza lincolnii (Audubon, 1834)) or seasonally (long daylight versus short daylight length) within a species. Breathing responses were assessed by stepwise reductions in inspired O2 tension, 21, 16, 12, 9, 7, and 5 kPa during long and short days. Ventilation increased in hypoxia in all species, although song sparrows and Lincoln's sparrows exhibited greater increases in ventilation in severe hypoxia compared to house sparrows. All species became more sensitive to hypoxia during short days compared to long days (increased breathing frequency and total ventilation), with reduced pulmonary oxygen extraction. Although all sparrows had similar ventilatory responses in moderate hypoxia, our findings suggest that migratory sparrows breathe more effectively in severe hypoxia compared to house sparrows, which would be important for maintaining oxygen uptake during migratory flights.
Perturbations of massless external fields in a special Horndeski hairy black hole
Authors: Yang Zhen-Hao , Lei Yun-He , Kuang Xiao-Mei , Wu Jian-Pin 
Published: February 2024

AbstractIn this paper, we study the propagations of external fields in a specific black hole solution in Horndeski theory, including the scalar field, electromagnetic field and Dirac field. We extensively explore the quasinormal frequencies, time evolution, greybody factors and emission rates of those massless perturbing fields by solving the corresponding master equations in the specific Horndeski hairy black hole. With the use of both numerical and analytical methods, we disclose the competitive/promotional influences of the Horndeski hair, spin and quantum momentum number of the external fields on those phenomenal physics. Our results show that this specific Horndeski hairy black hole is stable under those perturbations. Moreover, a larger Horndeski hair could enhance the intensity of energy emission rate for Hawking radiation of various particles, indicating that comparing to the Schwarzschild black hole, this specific Horndeski hariy black hole could have longer or shorter lifetime depending on the sign of the Horndeski hair.
Thermal noise-limited beam balance as prototype of the Archimedes vacuum weight experiment and B-L dark photon search
Authors: Allocca Annalisa , Avino Saverio , Calloni Enrico , Caprara Sergio , Carpinelli Massimo , Contu Andrea , D’Onofrio Luca , D’Urso Domenico , De Rosa Rosario , Errico L. , Esposito Marina , Gagliardi Gianluca , Grilli Marco , Mangano Valentina , Marsella Maria , Naticchioni Luca , Pasqualetti Antonio , Pepe Gianpiero , Perciballi Maurizio , Puppo Paola , Rapagnani Piero , Ricci Fulvio , Rosa Luigi , Rovelli Carlo , Rozza Davide , Ruggi Paolo , Saini Naurang L. , Sequino Valeria , Sipala Valeria , Stornaiuolo Daniela , Tafuri Francesco , Trozzo Lucia 
Published: February 2024

AbstractWe describe the behavior of a beam balance used for the measurement of small forces, in macroscopic samples, in tens of mHz frequency band. The balance, which works at room temperature, is the prototype of the cryogenic balance of the Archimedes experiment, aimed at measuring the interaction between electromagnetic vacuum fluctuations and the gravitational field. The balance described has a 50-cm aluminum arm and suspends an aluminum sample of 0.2 Kg and a lead counterweight. The read-out is interferometric, and the balance works in closed loop. It is installed in the low seismic noise laboratory of SAR-GRAV (Sardinia—Italy). Thanks to the low sensing and actuation noise and finally thanks to the low environmental noise, the sensitivity in torque $$\tilde{\tau _n}$$

τ
n

~

is about $$\tilde{\tau _n} \approx 2*10^{-12} \rm{Nm}/\sqrt {{\text{Hz}}}$$

τ
n

~

≈
2

∗

10

-
12

Nm
/

Hz

at 10 mHz and reaches a minimum of about $$\tilde{\tau _n} \approx 7*10^{-13} \rm{Nm}/\sqrt {{\text{Hz}}}$$

τ
n

~

≈
7

∗

10

-
13

Nm
/

Hz

at tens of mHz, corresponding to the force sensitivity $$\tilde{F_n}$$

F
n

~

of $$\tilde{{F_{n} }} \approx 3*10^{{ - 12}} {\text{N/}}\sqrt {{\text{Hz}}}$$

F
n

~

≈
3

∗

10

-
12

N/

Hz

. The achievement of this sensitivity, which turns out to be compatible with thermal noise estimation, on the one hand, demonstrates the correctness of the optical and mechanical design and on the other paves the way to the completion of the final balance. Furthermore, since the balance is equipped with weight and counterweight made of different materials, it is sensitive to the interaction with dark B-L photons. A first very short run made to evaluate constraints on B-L dark photon coupling shows encouraging results that will be discussed in view of next future scientific runs.
Role of Preimplantation Genetic Testing in Indian Women with Advanced Maternal Age to Optimize Reproductive Outcomes
Authors: Mantravadi Krishnachaitanya , Gedela Durga Rao , Rawat Beena , Chauhan Pooja 
Published: February 2024

Purpose: Does preimplantation genetic testing for aneuploidy (PGT-A) in embryos help women of advanced maternal age (AMA) of Indian origin to achieve better reproductive outcomes? Methods: In this retrospective study, a total of 267 patients were recruited, of which 53 patients (PGT-A group) consented to PGT-A, followed by euploid embryo transfer, whereas the remaining 214 patients (non-PGT-A group) underwent frozen embryo transfer (FET) of unscreened morphologically graded blastocysts. Results: A significant increase in the clinical pregnancy rate was observed in the PGT-A group when compared to the non-PGT-A group (71.6% vs. 51%, [Formula: see text]), while the miscarriage rate was found to be lower in the PGT-A group compared to the non-PGT-A group (11% vs. 25%, [Formula: see text]). The live birth rates were also significantly better in PGT-A group (60.3% vs. 25.6%, [Formula: see text]). In the PGT-A group, similarly, the implantation rate was found to be significantly higher than in the non-PGT-A group (53% vs. 33%, [Formula: see text]). Conclusions: The data suggest that PGT-A testing in women of AMA can improve their reproductive outcomes. Role of PGT-A seemed equally efficient in women of Indian origin and showed no difference based on ethnicity.
Social Determinants of Health Including Child Opportunity Index Leading to Gaps in Care for Patients With Significant Congenital Heart Disease
Authors: Zaidi Abbas H. , Saleeb Susan F. , Gurvitz Michelle , Bucholz Emily , Gauvreau Kimberlee , Jenkins Kathy J. , de Ferranti Sarah D. 
Published: February 2024

Background
Gaps in care (GIC) are common for patients with congenital heart disease (CHD) and can lead to worsening clinical status, unplanned hospitalization, and mortality. Understanding of how social determinants of health (SDOH) contribute to GIC in CHD is incomplete. We hypothesize that SDOH, including Child Opportunity Index (COI), are associated with GIC in patients with significant CHD.

Methods and Results

A total of 8554 patients followed at a regional specialty pediatric hospital with moderate to severe CHD seen in cardiology clinic between January 2013 and December 2015 were retrospectively reviewed. SDOH factors including race, ethnicity, language, and COI calculated based on home address and zip code were analyzed. GIC of >3.25 years were identified in 32% (2709) of patients. GIC were associated with ages 14 to 29 years (
P
<0.001), Black race or Hispanic ethnicity (
P
<0.001), living ≥150 miles from the hospital (
P
=0.017), public health insurance (
P
<0.001), a maternal education level of high school or less (
P
<0.001), and a low COI (
P
<0.001). Multivariable analysis showed that GIC were associated with age ≥14 years, Black race or Hispanic ethnicity, documenting <3 caregivers as contacts, mother's education level being high school or less, a very low/low COI, and insurance status (C statistic 0.66).

Conclusions
One‐third of patients followed in a regional referral center with significant CHD experienced a substantial GIC (>3.25 years). Several SDOH, including a low COI, were associated with GIC. Hospitals should adopt formal GIC improvement programs focusing on SDOH to improve continuity of care and ultimately overall outcomes for patients with CHD.
AT1‐AA Is Produced in Offspring in Response to Placental Ischemia and Is Lowered by B‐Cell Depletion Without Compromising Overall Offspring Health
Authors: Campbell Nathan , Deer Evangeline , Solise Dylan , Cornelius Denise C. , Turner Ty , Amaral Lorena M. , Herrock Owen , Jordan Ariel , Shukla Shivani , Ibrahim Tarek , LaMarca Babbette 
Published: February 2024

Background
Preeclampsia, new‐onset hypertension during pregnancy alongside other organ dysfunction, is the leading cause of mortality for the mother and low birth weight for the baby. Low birth weight contributes to high risk of cardiovascular disorders later in life. Women with preeclampsia have activated B cells producing agonistic autoantibodies to AT1‐AA (angiotensin II type I receptor). We hypothesize that rituximab, a B cell‐depleting chemotherapeutic, will deplete maternal B cells in reduced uterine perfusion pressure (RUPP) rats without worsening the effect of placental ischemia on pup growth and survival.

Methods and Results
To test this hypothesis, the RUPP procedure was performed, and rituximab was continuously infused via miniosmotic pump. Maternal blood and tissues were collected. A separate group of dams were allowed to deliver, pup weights were recorded, and at 4 months of age, tissues were collected from offspring. Immune cells were measured via flow cytometry, and AT1‐AA was quantified using a contraction bioassay. Blood pressure increased in RUPP rats and was normalized with rituximab treatment. RUPP offspring also had increased circulating B cells, cytolytic natural killer cells, and increased circulating AT1‐AA, which were normalized with maternal rituximab treatment. This is the first study to analyze the AT1‐AA in RUPP offspring, which was normalized with rituximab.

Conclusions
Our findings indicate that perinatal rituximab lowers maternal mean arterial pressure in RUPP rats and improves birth weight, circulating AT1‐AA, and circulating natural killer cells, indicating that rituximab improves adverse fetal outcomes in response to placental ischemia.
Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction
Authors: Doiron Jake E. , Li Zhen , Yu Xiaoman , LaPenna Kyle B. , Quiriarte Heather , Allerton Timothy D. , Koul Kashyap , Malek Andrew , Shah Sanjiv J. , Sharp Thomas E. , Goodchild Traci T. , Kapusta Daniel R. , Lefer David J. 
Published: February 2024

Background
The renal sympathetic nervous system modulates systemic blood pressure, cardiac performance, and renal function. Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF).
We investigated the effects of renal sympathetic denervation performed at early or late stages of HFpEF progression.

Methods and Results
Male ZSF1 obese rats were subjected to radiofrequency renal denervation (RF‐RDN) or sham procedure at either 8 weeks or 20 weeks of age and assessed for cardiovascular function, exercise capacity, and cardiorenal fibrosis. Renal norepinephrine and renal nerve tyrosine hydroxylase staining were performed to quantify denervation following RF‐RDN. In addition, renal injury, oxidative stress, inflammation, and profibrotic biomarkers were evaluated to determine pathways associated with RDN. RF‐RDN significantly reduced renal norepinephrine and tyrosine hydroxylase content in both study cohorts. RF‐RDN therapy performed at 8 weeks of age attenuated cardiac dysfunction, reduced cardiorenal fibrosis, and improved endothelial‐dependent vascular reactivity. These improvements were associated with reductions in renal injury markers, expression of renal NLR family pyrin domain containing 3/interleukin 1β, and expression of profibrotic mediators. RF‐RDN failed to exert beneficial effects when administered in the 20‐week‐old HFpEF cohort.

Conclusions
Our data demonstrate that early RF‐RDN therapy protects against HFpEF disease progression in part due to the attenuation of renal fibrosis and inflammation. In contrast, the renoprotective and left ventricular functional improvements were lost when RF‐RDN was performed in later HFpEF progression. These results suggest that RDN may be a viable treatment option for HFpEF during the early stages of this systemic inflammatory disease.
Regional Precipitation Regimes and Evaluation of National Precipitation Datasets against Satellite-Based Precipitation Estimates, Republic of Georgia
Authors: Tsitelashvili Nika , Biggs Trent , Mu Ye , Trapaidze Vazha 
Published: February 2024

Abstract
Analyzing water resources in areas with few hydrometeorological stations, such as those in post-Soviet countries, is difficult due to station closures after 1989. In Caucasus, evaluations often rely on outdated data from nearby rivers. We evaluated one national-level precipitation dataset, the Water Balance of Georgia (WBG) with two satellite-based precipitation products from 1981 to 2021, including the Climate Hazards Group Infrared Precipitation with Station (CHIRPS) data and CHIRPS blended with a dense rain gauge network (geoCHIRPS). We modeled mean annual precipitation from geoCHIRPS as a function of coastal distance and elevation. CHIRPS underestimated precipitation in the cold and wet seasons (R2 = 0.74, r = 0.86) and overestimated dry season precipitation, while geoCHIRPS performed well in all seasons (R2 = 0.86, r = 0.92). Distance from the coast was a more important predictor of precipitation than elevation in western Georgia, while precipitation correlated positively with elevation in the east. At four hydroelectric plants, the underperformance as a percentage of capacity (∼37%) corresponds with the percentage difference between differences in precipitation products (∼38%), suggesting that plants designed based on WBG may be systematically overdesigned, but further work is needed to determine the reasons for the underperformance of the plants and frequency. We conclude that 1) the existing WBG does not accurately reflect elevation–precipitation relationships near the coast, and 2) for accurate analysis of spatiotemporal precipitation variability and its impacts on hydropower generation and environmental and sustainable water resource management, it is essential to calibrate satellite-based precipitation estimates with additional rain gauge data.
Strategies used by Occupational Therapists to overcome return-to-work obstacles perceived by workers with common mental disorders
Authors: Robitaille-Beaumier Eve-Lyne , Lachance Jean-Philippe , Larivière Nadine , Corbière Marc 
Published: February 2024

Introduction: Few studies have focused on identifying distinctive strategies implemented for overcoming return-to-work (RTW) barriers perceived by people with common mental disorders (CMDs), and their impact on RTW. The study aimed to document the strategies used by occupational therapists to overcome RTW obstacles identified by people with CMDs, and to explore the impact of these strategies on employees’ self-efficacy. Method: Ten workers followed by three occupational therapists were recruited for this study. Based on the participants’ ROSES scores, the occupational therapists identified in a logbook the dimensions to be worked on and the strategies they implemented for each dimension. Data was analyzed with the use of thematic analysis and descriptive statistics. Results: Three dimensions of the ROSES were most frequently targeted by the occupational therapists: job demands, fear of relapse and difficult relation with the immediate supervisor. The main strategies used to overcome these obstacles were work-oriented and Cognitive Behavioral Therapy-based interventions. Most of the participants have increased their self-efficacy for RTW after using these strategies. Eighty percent of the participants returned to work at the end of the study. Conclusion: The use of work-oriented and CBT-based interventions by occupational therapists appears to be useful in improving participants’ self-efficacy and promoting their return to work.
Failure of bamlanivimab with selection of E484K mutation in an allogeneic stem cell transplant recipient with nosocomial SARS-CoV-2 infection
Authors: Boussen Inès , Salmona Maud , Sicre De Fontbrune Flore , Xhaard Aliénor , De Castro Nathalie , Delaugerre Constance , Chaix Marie-Laure , Molina Jean-Michel 
Published: February 2024

We report the case of an allogeneic stem cell transplant recipient with nosocomial acquisition of SARS-CoV-2 infection who received antispike neutralizing monoclonal antibody bamlanivimab 2 days after diagnosis of SARS-CoV-2 infection but progressed to severe COVID-19 pneumonia and died with the selection of E484K/Q resistance mutations to bamlanivimab.
Total hip arthroplasty in patients with common pediatric hip orthopedic pathology
Authors: De Salvo Sara , Sacco Ricardo , Mainard Nicolas , Lucenti Ludovico , Sapienza Marco , Dimeglio Alain , Andreacchio Antonio , Canavese Federico 
Published: February 2024

Purpose: Literature regarding total hip arthroplasty for pediatric hip diseases is scarce. This review aims to portray the various orthopedic conditions of childhood that can lead to significant impairment of the hip joint and, ultimately, to total hip arthroplasty in adolescence and adulthood. Methods: In total, 61 out of 3666 articles were selected according to (1) the diagnosis of one of the 12 pediatric hip pathologies (Legg–Perthes–Calvé disease, developmental dysplasia of the hip, slipped capital femoral epiphysis, neuromuscular hip dysplasia, post-traumatic avascular necrosis of the proximal femur, juvenile rheumatoid arthritis, achondroplasia, spondyloepiphyseal dysplasia, mucopolysaccharidosis, mucolipidosis, hip infections, and tumors) that required total hip arthroplasty; (2) minimum follow-up of 16 months; (3) assessed outcome with a clinical or radiologic score; (4) Methodological Items for Non-Randomized Studies quality score of 9 or higher. The following information for each pathology was retrieved: mean age at total hip arthroplasty, reason for total hip arthroplasty, type of total hip arthroplasty, surgical technique, mean follow-up, and outcomes. Results: Overall, the mean age at total hip arthroplasty for pediatric hip disease is in the sixth and seventh decade, except for tumors and skeletal dysplasias. The reason for performing total hip arthroplasty is often osteoarthrosis and abnormal anatomy. Prosthesis types change based on patient’s conditions and technological advances; custom-made implants are used for tumors, juvenile rheumatoid arthritis, and skeletal dysplasias; for other diseases, the most frequent are modular cementless implants. Outcomes are generally good, and all studies portray functional and pain improvements. Conclusion: Total hip arthroplasty is performed more frequently than in the past in patients with pediatric hip pathologies; it enhances patients’ quality of life by reducing pain and improving function. However, revision rate in these patients is not negligible.