bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the mSin3A-Histone Deacetylase 1/2 Corepressor Complex with the Mouse Steroidogenic Acute Regulatory Protein Gene
Authors: Clem Brian F. , Clark Barbara J. 
Published: August 2005

AbstractSeveral factors have been identified in the transcriptional repression of the steroidogenic acute regulatory protein (StAR) gene promoter; yet, no associating corepressor complexes have been characterized for the mouse promoter in MA-10 mouse Leydig tumor cells. We now report that Sp3, CAGA element binding proteins, and a corepressor complex consisting of mSin3A, histone deacetylase (HDAC)1, and HDAC2 associates with a transcriptional repressor region within the mouse StAR promoter. 5′-Promoter deletion analysis localized the negative regulatory region between −180 and −150 bp upstream of the transcription start site, and mutations in both the CAGA and Sp binding elements were required to relieve the repression of basal StAR promoter activity. Protein-DNA binding analysis revealed Sp3 and specific CAGA element-binding protein(s) associated with the repressor region. Coimmunoprecipitation analysis identified the presence of the mSin3A, HDAC1, and HDAC2 corepressor complex in MA-10 cells. Furthermore, chromatin immunoprecipitation assays revealed Sp3, mSin3A, and HDAC1/2 association with the proximal region of the StAR promoter in situ. In addition, HDAC inhibition resulted in a dose-dependent activation of a mouse StAR reporter construct, whereas mutations within the repressor region diminished this effect by 44%. In sum, these data support a novel regulatory mechanism for transcriptional repression of the mouse StAR promoter by DNA binding of Sp3 and CAGA element-binding proteins, and association of the Sin3 corepressor complex exhibiting HDAC activity.
Carbon monoxide clathrate hydrates: Equilibrium data and thermodynamic modeling
Authors: Mohammadi Amir H. , Anderson Ross , Tohidi Bahman 
Published: August 2005

AbstractCarbon monoxide occurs in abundance throughout the cosmos, potentially in clathrate form, whereas on Earth, it forms a notable constituent of industrial flue gases. It has been proposed that hydrate technology could be used in CO2 separation from flue gases, and in subsea flue gas CO2 disposal. This—and the likely widespread occurrence of CO clathrates in the cosmos—means it is important that the phase behavior of CO hydrates is known. Here, we present experimental H‐L‐V (hydrate–liquid–vapor) equilibrium data for CO, COCO2, and COC3H8 (propane) clathrate hydrates. Data were generated by a reliable step‐heating technique validated using measured data for CO2 and CH4 hydrates. Data for CO and COC3H8 clathrates have been used in the optimization of Kihara potential parameters for CO, reported here, facilitating the extension of a thermodynamic model to the prediction of CO hydrate equilibria. Model predictions are validated against independent experimental data for COCO2 (structure I) systems, with good agreement being observed. © 2005 American Institute of Chemical Engineers AIChE J, 2005
Acro‐dermato‐ungual‐lacrimal‐tooth (ADULT) syndrome: Report of a child with phenotypic overlap with ulnar‐mammary syndrome and a new mutation in TP63
Authors: Slavotinek Anne M. , Tanaka June , Winder Alison , Vargervik Karin , Haggstrom Anita , Bamshad Michael 
Published: August 2005

AbstractWe report on a new patient with clinical findings consistent with acro‐dermato‐ungual‐lacrimal‐tooth (ADULT) syndrome. The child had sparse hair, extensive freckling, lacrimal duct stenosis, oligodontia, dystrophic nails, reduced sweating, and bilateral athelia. Examination of his hands showed ulnar ray hypoplasia with bilateral fifth finger brachydactyly and camptodactyly. He also had surgical repair of an imperforate anus. Mutation analysis of TP63 showed a single nucleotide substitution, c.G518A, predicting a novel missense mutation, p.V114M in exon 4. This is the third mutation to be reported in TP63 in ADULT syndrome. © 2005 Wiley‐Liss, Inc.
Domino 6π‐Electrocyclization/Diels–Alder Reactions on 1,6‐Disubstituted (E,Z,E)‐1,3,5‐Hexatrienes: Versatile Access to Highly Substituted Tri‐ and Tetracyclic Systems
Authors: von Essen Regina , Frank Daniel , Sünnemann Hans Wolf , Vidović Denis , Magull Jörg , de Meijere Armin 
Published: August 2005

AbstractThe (E,Z,E)‐1,3,5‐hexatrienes1 a,2 a, band3 bundergo 6π‐electrocyclization within 15–30 min upon heating to 200–215 °C. While the cyclohexene‐annelated products8 a, bwere stable, the analogous cyclopentene‐ and cycloheptene‐annelated derivatives7 aand9 beasily underwent dehydrogenation to the corresponding aromatic compounds10 aand12 bduring the work‐up. The cyclohexadiene derivatives8 a, bwere employed in thermal Diels–Alder reactions with 4‐phenyl‐3H‐1,2,4‐triazoline‐3,5‐dione (PTAD) and tetracyanoethylene (TCNE) to give the expected [4+2] cycloadducts13 aand14 ain good yields (60 and 78 %). The initially formed cycloadduct of8 aand dimethyl acetylenedicarboxylate (DMAD) underwent a subsequent retro‐Diels–Alder reaction to give the tetrahydronaphthalene11 b(47 %). Under high pressure (10 kbar), the cycloadduct15 awas formed at room temperature and could be isolated in 44 % yield. TCNE andN‐phenylmaleimide with8 aunder high pressure also led to the [4+2] cycloadducts14 aand16 ain good yields (60 and 77 %). The 6π‐electrocyclization and subsequent Diels–Alder reaction, when performed as a one‐pot domino process, provided direct access to Diels–Alder products of intermediately formed 6π‐electrocyclization products, for example from the 1,3,5‐hexatrienes1 a, b,2 a, b,3 band TCNE to the corresponding tricyclic products17 a, b,14 a, b,18 bin moderate to good yields (27–80 %) depending on the nature of the alkoxycarbonyl group. Such sequential reactions withN‐phenylmaleimide, maleic anhydride, dimethyl maleate and fumarodinitrile, the latter two under high pressure (10 kbar), worked as well to yield16 b(70 %),19 a, b(19, 32 %) and20 b(39 %) and21 b(76 %), respectively. With PTAD, however, the hexatrienes2 a, breacted at ambient temperature without 6π‐electrocyclization to give the formal [4+2] cycloadducts27 a, b(48 and 46 %), most probably via zwitterionic intermediates23 a, band25 a, b.
Stereoselective acylation of a racemic amine with Cα‐methyl phenylglycine‐based dipeptide 5(4H)‐oxazolones
Authors: Moretto Alessandro , Peggion Cristina , Formaggio Fernando , Crisma Marco , Kaptein Bernard , Broxterman Quirinus B. , Toniolo Claudio 
Published: August 2005

AbstractReactions of a racemic amine with chiral, Nα‐acetylated, Cα‐methyl l‐phenylglycine‐based dipeptide 5(4H)‐oxazolones proceed diastereoselectively to give predominantly dipeptide alkylamides comprising d‐α‐phenylethylamine. Diastereoselectivity is remarkably sensitive to solvent polarity and reaction temperature but not significantly to the nature of the Cα‐tetrasubstituted α‐amino acid at position 1 of the dipeptide. The β‐turn 3D structures of the aminolysis products were established in CDCl3 solution by FT‐IR absorption and in one case in the crystal state by X‐ray diffraction as well. © 2005 Wiley‐Liss, Inc. Chirality 17:481–487, 2005.
Interstitial high‐dose‐rate brachytherapy combined with cervical dissection on head and neck cancer
Authors: Pellizzon Antonio Cassio Assis , dos Santos Novaes Paulo Eduardo Ribeiro , Conte Maia Maria Aparecida , Ferrigno Robson , Fogarolli Ricardo , Salvajoli João Vitor , Kowalski Luiz Paulo 
Published: August 2005

AbstractBackground.The literature is scarce regarding the use of interstitial high‐dose‐rate brachytherapy (I‐HDR) as adjuvant treatment of the cervical region, and most reports are focused on primary tumors of the mobile tongue and oropharynx. We evaluated the outcome and morbidity related to an institutional treatment policy, using I‐HDR as the sole adjuvant treatment or in combination with external beam radiotherapy (EBRT) at the Departments of Radiation Oncology and Head and Neck Surgery, Hospital do Cancer, Sao Paulo, Brazil.Methods.From October 1994 to December 2003, charts of 42 patients who had biopsy‐proven cervical head and neck cancer, with a median follow‐up of 36 months (range, 8–111 months), were reviewed. The median age of the patients was 55 years (range, 31–76 years), and the male/female ratio was 4.25:1.00. Thirty‐five patients had previous irradiation with EBRT, with doses ranging from 30 Gy to 65 Gy (median, 52 Gy). The total dose of I‐HDR ranged from 12 Gy to 48 Gy (median, 24 Gy), given in three to 14 fractions (median, 6 fractions) in 2 to 8 days (median, 4 days).Results.The total treatment time ranged from 19 to 83 days (median, 35 days). The 5‐ and 8‐year overall survival (OS) rates were 52.5% and 48.1%, respectively; and the relapse‐free survival (RFS) rates were 48.5% and 38.1%, respectively. The only statistically significant prognostic factor for RFS and OS at 5 and 8 years was margin status (p = .0050). Four patients (9.5%) had late adverse side effects, such as local dehiscence (n = 2), local ulcer (n = 1), and extensive neck fibrosis (n = 1), not related to a higher dose to the skin or graft.Conclusion.These results suggest that I‐HDR can be recommended in selected patients with first presentation lesions, local recurrences, or second primary carcinomas, even with a previous course of EBRT, but further studies are eagerly awaited to delineate the optimum schedule for this combination‐treatment modality. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005
B and CTL responses to the ALK protein in patients with ALK‐positive ALCL
Authors: Ait‐Tahar Kamel , Cerundolo Vincenzo , Banham Alison H. , Hatton Christian , Blanchard Tom , Kusec Rajko , Becker Marion , Smith Geoffrey L. , Pulford Karen 
Published: August 2005

AbstractAnaplastic lymphoma kinase (ALK)‐positive anaplastic large cell lymphoma (ALCL) has a good prognosis compared to ALK‐negative ALCL, possibly as a result of the immune recognition of the ALK proteins. The aim of our study was to investigate the presence of both a B and cytotoxic T cell (CTL) response to ALK in ALK‐positive ALCL. We confirmed the presence of an antibody response to ALK in all 9 ALK‐positive ALCL patients investigated. An ELISpot assay was used to detect a γ‐interferon (IFN) T cell response after short term culture of mononuclear blood cells with 2 ALK‐derived HLA‐A*0201 restricted peptides: ALKa and ALKb. A significant γ‐IFN response was identified in all 7 HLA‐A*0201‐positive ALK‐positive ALCL patients but not in ALK‐negative ALCL patients (n = 2) or normal subjects (n = 6). CTL lines (>95% CD8‐positive) raised from 2 ALK‐positive ALCL patients lysed ALK‐positive ALCL derived cell lines in a MHC‐Class I restricted manner. This is the first report of both a B cell and CTL response to ALK in patients with ALK‐positive ALCL. This response persisted during long‐term remission. The use of modified vaccinia virus Ankara (MVA) to express ALK is also described. Our findings are of potential prognostic value and open up therapeutic options for those ALK‐positive patients who do not respond to conventional treatment. © 2005 Wiley‐Liss, Inc.
Energy and nutrient digestibilities in wheat dried distillers' grains with solubles fed to growing pigs
Authors: Nyachoti Charles M , House James D , Slominski Bogdan A , Seddon Ian R 
Published: August 2005

AbstractThe aim of this study was to characterize the nutritional profile and to determine the digestibilities of nutrients in wheat‐based dried distillers' grains with solubles (DDGS) fed to growing pigs. Six ileal cannulated barrows individually housed in metabolism crates were fed experimental diets which consisted of a basal wheat‐based diet or the basal diet with wheat replaced by 400 g kg−1 mixed wheat or winter wheat DDGS in a replicated 3 × 3 Latin square design. Ileal digesta and fecal samples were collected for determining apparent ileal (AID) and apparent total tract digestibilities (ATTD), respectively. The contents of proximate components and amino acids in DDGS were about three times higher than in wheat. The AID and ATTD of dry matter, nitrogen and energy were lower (P < 0.05) in DDGS compared with wheat. The DDGS samples had lower (P < 0.05) AID of amino acids compared with wheat; average values for lysine, threonine and isoleucine in DDGS were 43.8, 62.9 and 68.0%, respectively. The ileal and fecal digestible energy content in DDGS averaged 9.7 ± 1.18 and 13.5 ± 0.61 MJ kg−1, respectively. Respective values for wheat were 13.3 ± 0.52 and 14.6 ± 0.22 MJ kg−1 and both were higher (P < 0.05) than in DDGS. Copyright © 2005 Society of Chemical Industry
The influence of oil type and frying temperatures on the texture and oil content of French fries
Authors: Kita Agnieszka , Lisińska Grażyna 
Published: August 2005

AbstractThe purpose of the present study was to determine the effects of the frying medium and temperatures on fat content and texture of French fries. The material taken for the study consisted of seven types of vegetable oil: refined sunflower, rape, soy, olive oil, palm, partially hydrogenated rape oil (modified oil I) and a blend of vegetable oils (modified oil II). The French fries prepared from Asterix potato variety were fried at oils heated to 150, 160, 170, 180 and 190 °C. The length of frying (12, 10, 8, 6.5 and 4.5 min, respectively) depended on oil temperature. Fat content and the texture of French fries were determined. The type of frying medium significantly affects the texture of French fries. Temperature influenced both the fat content and texture of product. The increase of frying temperature decreased fat uptake and hardness of French fries. French fries fried in rape oil exhibited the most delicate texture and the lowest oil absorption when compared with French fries fried in other types of oil under investigation. Copyright © 2005 Society of Chemical Industry
Effect of Maillard‐based conjugation with dextran on the functional properties of lysozyme and casein
Authors: Aminlari Mahmoud , Ramezani Roghayeh , Jadidi Fatemeh 
Published: August 2005

AbstractThe purpose of this research was to find the best experimental conditions for glycosylation of lysozyme and casein with dextran, and to investigate the effect of glycosylation on the functional properties of these proteins. Glycosylation was performed by allowing proteins to react with dextran under Maillard reaction conditions. The extent of glycosylation was determined by sugar analysis, SDS‐PAGE, gel filtration and cation‐exchange chromatography. Glycosylation of lysozyme with a 1:5 weight ratio of protein to dextran, held at 60 °C for one week under a relative humidity of 79% resulted in coupling of 3.0 mole dextran to one mole lysozyme. In the case of casein, at 60 °C, 48 h and 79% relative humidity, 0.1 and 0.13 mole dextran was attached to one mole of casein when a weight ratio of protein to dextran of 1:5 and 1:7.5 was used, respectively. A decrease in the degree of glycosylation occurred when samples were incubated for 72 h. Enzymatic activity of glycosylated lysozyme was reduced by 20% compared with unmodified lysozyme (P < 0.05). Both proteins exhibited improved solubility at different pH values (3, 7 and 9), different temperatures (25, 40 and 60 °C) and increased heat stability, with a better emulsion activity and emulsion stability than with un‐modified proteins (P < 0.05). These changes might increase the applicability of lysozyme as a natural antimicrobial and casein as a protein ingredient in different food systems. Copyright © 2005 Society of Chemical Industry
Changes in quality characteristics during cold storage of shucked mussels (Mytilus galloprovincialis) and selected chemical decomposition indicators
Authors: Erkan Nuray 
Published: August 2005

AbstractThe following chemical changes were observed during the cold storage of mussels for 6 days at 4 °C. Total volatile basic nitrogen (TVB‐N, mg N per 100 g) and trimethylamine values (TMA‐N, mg N per 100 g) were increased from 22.55 and 5.96 mg per 100 g at day 0 to 12.38 and 0.42 mg per 100 g, respectively, at the end of the storage period. The indole value and putrescine concentration were increased from 15.36 µg kg−1 and 24.7mg kg−1 to 34.46 µg kg−1 and 63.86 mg kg−1, respectively, on the fourth day of storage. The pH was slightly reduced and tyramine and cadaverine were not detected during storage. TVB‐N, TMA‐N and indole value could be selected as decomposition indicators for mussels during their cold storage. Acceptable limits of 15 mg per 100 g for TVB‐N, 3 mg per 100 g for TMA‐N, 35 µg kg−1 for indole and 60 mg kg−1 for putrescine are suggested. Sensory and chemical results indicated that the shelf‐life of mussels at 4 °C is limited to 4 days. Copyright © 2005 Society of Chemical Industry
International cooperative ataxia rating scale (ICARS): Appropriate for studies of Friedreich's ataxia?
Authors: Cano Stefan J. , Hobart Jeremy C. , Hart Paul E. , Korlipara L.V. Prasad , Schapira Anthony H.V. , Cooper J. Mark 
Published: August 2005

AbstractClinicians require scientifically rigorous, clinically meaningful rating scales to evaluate the health impact of disease and treatment that cannot be measured using conventional laboratory instruments. This study evaluated the psychometric properties of the International Cooperative Ataxia Rating Scale (ICARS), a commonly used clinician‐rated measure, in Friedreich's ataxia (FRDA). People with confirmed FRDA were assessed by using the ICARS. Two assumptions of its measurement model were tested: the legitimacy of reporting ICARS scores in FRDA, and the acceptability, reliability, and validity of total and subscale scores. Seventy‐seven people with FRDA were assessed. The ICARS total score effectively satisfied all psychometric criteria tested. The posture and gait disturbances subscale also performed well. The other three subscales did not pass standard criteria for tests of scaling assumptions, reliability, and validity. This small study recommends only the use of the ICARS total score as a measure of FRDA. However, the extent to which this score quantifies the true extent of FRDA remains uncertain as our validity testing was limited, partly by the lack of appropriate validating measures. Further validity testing, and examination of responsiveness, is required before the ICARS can be recommended as an outcome measure for treatment trials of FDRA. © 2005 Movement Disorder Society
Tau‐predominant–associated pathology in a sporadic late‐onset Hallervorden–Spatz syndrome
Authors: Zarranz Juan J. , Gómez‐Esteban Juan C. , Atarés Begoña , Lezcano Elena , Forcadas Maribel 
Published: August 2005

AbstractHallervorden–Spatz syndrome (HSS) is a heterogeneous clinicopathological disorder currently included within the broader title of neurodegeneration with brain iron accumulation (NBIA). The classic histological hallmarks of HSS are axonal spheroids and excessive iron‐containing granules accompanied by neuronal loss and gliosis in the globus pallidus and substantia nigra reticulata. In the modern literature, attention has been drawn to the co‐occurrence of two other histological markers: Lewy bodies mainly composed of abnormal α‐synuclein, and neurofibrillary tangles due to hyperphosphorilated tau aggregation. Discrepancies exist regarding the importance of these molecular changes and its relevance for the nosology of HSS. Most authors have emphasized the importance of the Lewy body–like pathology, favoring the inclusion of HSS within the α‐synucleinopathies. We report on a case of late‐onset HSS, with the typical histological findings restricted to the basal ganglia and cerebellum in which tau pathology was exceedingly more abundant than α‐synuclein pathology. This case contributes to the increasing evidence about the heterogeneity of HSS. We favor the view that the molecular changes and the protein misfolding underlying the Lewy body and tangle formation in HSS/NBIA are secondary to the main pathological process and should not be taken as the basis for its nosological classification. © 2005 Movement Disorder Society
Long‐term botulinum toxin treatment increases employment rate in patients with cervical dystonia
Authors: Skogseid Inger Marie , Røislien Jo , Claussen Bjørgulf , Kerty Emilia 
Published: August 2005

AbstractWe examined the impact of cervical dystonia (CD) and long‐term botulinum toxin (BTX) treatment on employment status. Data on employment status at onset of CD, at initiation of BTX treatment, and at evaluation of long‐term treatment were obtained from 62 CD patients aged 31–66 years (median, 53 years; 61% females) who had been treated for a median of 5 years (range, 1.5–10 years). The employment rate fell from 84% at the onset of CD to 47% before initiation of BTX treatment. With long‐term BTX treatment, 72% of those who worked at the initiation of treatment stayed employed, and 67% of those on sick leave returned to work. A younger age and a higher level of education increased the probability of being employed and avoiding disability benefits. Among those who were younger than 55 years at evaluation of BTX treatment (n = 40), the employment rate increased from 47% to 65% with treatment, and among the male patients, it reached the level of the general population (86%). About half of the 34% who received disability benefits did so already before the BTX treatment was initiated. © 2005 Movement Disorder Society
A Demon at Work
Authors: Crenshaw James L. 
Published: August 2005

AbstractRather than defining God as essentially good, one can attribute a flawed character to the supreme being. Two biblical stories reflect this approach to theodicy, describing YHWH, the special name for Israel’s God, as demonic. In Gen 22:1–19 God asks Abraham to sacrifice his only son Isaac on a distant mountain, and in Job 1–2 God wrecks human lives through a heavenly agent, the Satan, without cause (khinnam). Other harrowing tales in the Bible describe objectionable divine conduct best viewed as demonic.
Punishment for Sin
Authors: Crenshaw James L. 
Published: August 2005

AbstractBelief in individual reward and retribution was subscribed to by every segment of the population in the ancient world. Not surprisingly, it became the dominant theodicy, expressed quite simply in language familiar to one and all: “Whoever sows iniquity will reap a harvest of trouble.” Reasoning from faring ill to doing ill, all four of Job’s friends accuse him of wickedness, even though readers know that both God and the narrator have vouched for his integrity. Like Job’s attackers, the author of Psalm 37 attests the rigidity of this dogma when claiming never to have seen the righteous forsaken or impoverished, as does Israelite historiography and liturgical prayer from the period of the second temple. Jesus’ rejection of this view in John 9:7 stands alongside his acceptance of the concept of reward and punishment elsewhere.
Introduction
Authors: Kieckhefer Richard 
Published: August 2005

Abstract
The basic categories of analysis (spatial dynamics, centering focus, aesthetic impact, and symbolic resonance) and the traditions of church-building (classic sacramental churches, classic evangelical churches, and modern communal churches) are explained here. The first main argument of the book is that classic sacramental churches have the density of poetry and thus require interpretation, while the other traditions have the familiarity of prose and are more easily understood. The second main argument is that sacrality may be grounded not in separation (from the profane) but rather in association (with the narratives and experiences most significant to a religious tradition).