bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Symptoms and Neuroanatomical Substrates of Daytime Sleepiness in Parkinson’s Disease
Authors: Rosinvil Thaïna , Postuma Ronald , Rahayel Shady , Bellavance Amélie , Daneault Véronique , Montplaisir Jacques , Lina Jean-Marc , Carrier Julie , Gagnon Jean-François 
Published: October 2023

Abstract

Background: Clinical and neuroanatomical correlates of daytime sleepiness in Parkinson’s disease remain inconsistent in the literature.
Objectives: Two studies were conducted. The first study evaluated the interrelation between non-motor and motor symptoms associated with daytime sleepiness in Parkinson’s disease. The second study identified the neuroanatomical substrates associated with daytime sleepiness in Parkinson’s disease using magnetic resonance imaging.
Methods: Seventy-seven participants with Parkinson’s disease were included in the first study. They completed extensive clinical and cognitive testing in addition to a polysomnographic recording. Principal component analysis was performed to evaluate the interrelation between daytime sleepiness and clinical symptoms and to discriminate between individuals with (n=25) and without (n=52) excessive daytime sleepiness on the components identified. In the second study, 29 individuals with Parkinson’s disease also underwent MRI acquisition of T1-weighted images. Vertex-based cortical and subcortical surface analysis, deformation-based morphometry, and voxel-based morphometry were performed to assess the association between daytime sleepiness severity and structural brain changes in participants.
Results: Individuals with excessive daytime sleepiness showed a higher score on a component including higher dosage of dopaminergic agonist, motor symptoms severity, shorter sleep latency, and greater sleep efficiency. Moreover, increased daytime sleepiness severity was associated with a larger surface area in the right insula, contracted surfaces in the right putamen and right lateral amygdala, and a larger surface in the right posterior amygdala.
Conclusion: Daytime sleepiness in Parkinson’s disease was associated with dopaminergic agonist dosage, motor impairment, and objective sleep measures. Moreover, neuroanatomical changes in cortical and subcortical regions related to vigilance, motor, and emotional states were associated with more severe daytime sleepiness.
Performance of Bt cotton evaluated in relation to mulching and weed control measures in north-west India
Authors: DEVI PRIYANKA , SINGH KARMAL , SEWHAG MEENA , KUMAR SUSHIL 
Published: October 2023

Abstract
Weed infestation in cotton has been reported to offer severe competition and causing yield reduction to a large extent. Weeding via cultural practices is time consuming, tedious and expensive due to long duration of cotton crop and regular monsoon rains. Chemical weed control in cotton has been successfully utilized in the recent past. However, continuous use of similar herbicides leads to resistance in weeds against herbicides and when sprayed to the field herbicides not only suppress the weeds that are targeted but they can leave undesirable residues in the soil that are hazardous to environment. Therefore, a study was performed at cotton research area, Chaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana during two consecutive kharif season (2020 and 2021). The experiment was laid out in factorial randomized block design with two mulching levels (No mulch and Mulching with rice straw @ 7.5 t/ha) and seven weed management levels [Weedy check, Weed free, pendimethalin (PRE) 1.5 kg/ha fb two hoeing at 45 and 90 DAS, Two hoeing at 30 and 60 DAS fb quizalofop-p-ethyl 62.5 g/ha at 90 DAS, Two hoeing at 30 and 60 DAS fb propquizafop-p-ethyl 50 g/ha at 90 DAS, pendimethalin (PRE) 1.5 kg/ha fb one hoeing 45 DAS fb paraquat 0.5% (protected spray) at 90 DAS and pendimethalin (PRE) 1.5 kg/ha fb one hoeing 45 DAS fb glyphosate 1% (protected spray) at 90 DAS] with three replications. Mulching with rice straw @7.5 t/ha resulted in significantly higher seed cotton yield (3189 and 3084 kg/ha) and better weed control in comparison to no mulch (2990 and 3189 kg/ha) in 2020 and 2021 respectively. Among weed management levels apart from weed free, significantly lowest seed cotton yield (1841 and 1757 kg/ha) recorded in weedy check in comparison to other treatments while all other treatments were statistically at par with each other during both years of crop experimentation respectively. Herbicide efficiency index (7.13 and 7.31) achieved with application of pendimethalin (PRE) @1.5 kg/ha fb one hoeing at 45 DAS fb glyphosate 1% (protected spray) at 90 DAS during kharif 2020 and 2021 respectively
Study of evoked potentials and early development in premature infants
Authors: min kyeongil , Shin Hyun lee , Jeong Minjae , Kim Du Hwan , Park Myung Woo , Lee Byung Chan 
Published: October 2023

Abstract
This study aimed to investigate the relationship between evoked potentials (EP) and neurodevelopmental outcomes in preterm infants. Premature infants admitted to the neonatal intensive care unit of a tertiary referral hospital between March 2020 and March 2023 were included in the study. Among them, only those with EP at a corrected age of 40 weeks were included, meanwhile, infants who did not undergo the test or had abnormal results were excluded. Additionally, patients with follow-up developmental outcomes such as the Hammersmith Infant Neurological Examination (HINE) or the Gross Motor Function Measure (GMFM) were included. A total of 24 participants were included in this study. No significant differences in the clinical factors and results of the EP studies were observed between the two groups divided by a HINE score of 60. Hierarchical logistic regression analysis revealed that visual EP was the only factor that correlated with the lying and rolling domains of the GMFM (P = 0.028). A significant association was observed between the GMFM and visual EP. Integrating the visual EP latency with other parameters may improve clinical assessments to predict developmental outcomes beyond the dichotomous classification of normal or abnormal outcomes, possibly improving the accuracy of medical interventions and patient outcomes.
School Boarding, Bullying, and Students’ Mental Health in Rural China
Authors: Li Yunsen , Li Yunlu 
Published: October 2023

Abstract
This study aims to examine the effects of school boarding on the mental health of rural Chinese students using data from the National Children’s Study of China (NCSC). The OLS and estimates based on propensity score matching method show that boarding is not significantly associated with students’ self-confidence, self-esteem, self-concept, and belief in justice. Nonetheless, it is significantly correlated to lower subjective well-being, and higher levels of loneliness, depression, and anxiety. Further robustness test also supports the findings. Additionally, this paper finds that non-left-behind children, elementary students, and female students are more likely to experience the negative effects of boarding at school. The vital mechanism analysis indicates that the adverse effects of boarding may result from significantly increased school bullying in boarding schools.
Research and Application of a User Academic Profile Analysis Platform Based on AHP-EW
Authors: Yu Qian , Wang Jinmin , Wu Jinyuan , Liu Jing , Zhou Wei , Liu Rong , Zhang Yanqiu 
Published: October 2023

Abstract

Academic achievement is a crucial factor in evaluating the academic level of students. However, there is a problem in that academic performance solely reflects grades and cannot assess students' comprehensive abilities and qualities. To address this issue, we have developed and implemented a platform for the analysis of a user's academic profile based on the Analytic Hierarchy Process-Entropy Weight (AHP-EW) method. The platform comprises input and calculation modules for academic performance, construction and evaluation of quality evaluation indicators, diagnostic analysis reports, and knowledge graphs. It constructs students’ academic performance portraits, delivers academic diagnosis and analysis services for various educational regions and schools, and generates academic performance portrait across different levels. It improves the clarity, coherence, and comprehensibility of academic performance and plays a vital role in diagnosing, analyzing, evaluating, and providing feedback on academic performance.
hESC-derived mesenchymal stem cells Promote Oral Mucositis Healing via the PI3K/AKT Pathway
Authors: Lv Kejia , Gao Bicong , Shen Chenlu , Ye Weijia , Yao Yanan , Yao Hua 
Published: October 2023

Abstract
Objective
Oral mucositis (OM) is among the most pervasive adverse reactions caused by radiotherapy or chemotherapy during cancer treatment. This study focused on the reparative effects of human embryonic stem cell-derived mesenchymal stem cells (hESC-MSCs) in OM and possible mechanisms.
Materials and Methods
An ulcer model was created in the rat buccal mucosa to simulate OM, and hESC-MSCs were injected 48h later to assess their reparative effects. The efficacy of hESC-MSCs in regulating apoptosis and proliferation in LPS- or 5-FU-injured HaCaT cells was studied in vitro using a transwell coculture system. Subsequently, the PI3K inhibitor LY24002 was used to assess whether hESC-MSCs regulated injured HaCaT cells through PI3K/AKT pathway.
Results
We found that hESC-MSCs injection promoted OM healing in rats through the acceleration of re-epithelialization, and a decrease in apoptosis. Our findings also revealed that the hESC-MSCs treatment led to a reduction in the quantity of HaCaT cells undergoing apoptosis. Western blot analysis revealed that hESC-MSCs activated AKT, resulting in increased protein levels of PCNA and BCL-2, decreased protein levels of Bax and Caspase-3. Whereas, LY294002 reversed these changes.
Conclusions
hESC-MSCs promoted OM healing, inhibited LPS- or 5-FU-injured HaCaT cell apoptosis, and increased their proliferation via the PI3K/AKT pathway.
Community Based Screening for High Blood Pressure and Diabetes among Albaraha Residents, Khartoum Sudan 2022
Authors: MohammedElamin Khanssa , Sabir Mustafa , Abdulabgi Rasheeda , Emad Ola , Mohammed Ola , Mohammed Fatin , Awad Ibrahim , Fadulelmola Mohammed 
Published: October 2023

Abstract
Background:
Diabetes Mellitus (DM) and Hypertension constitutes a huge burden for low-income countries, so a screening program for identifying those at risk or at the early stages can be beneficial. The Aim of the study is to screen Albaraha residents for DM and high blood pressure.
Methods:
An observational descriptive cross sectional community based study, which was conducted in Khartoum state, Bahri city, Albaraha area, the population of which were Albaraha residents. A screening campaign was carried out for both DM and High blood pressure at the primary health care center at the area, between October-November 2022. A simple random sampling method was taken from individuals attending Albaraha primary health care center, whom fulfilled the inclusion criteria for this study, and a questionnaire assessing the risk/ predisposing factors was filled by all study participants. A single blood pressure reading of > 130/90 was regarded as high blood pressure and a Fasting blood glucose of > 126 mg/dl with a positive risk factor was considered to be DM. The collected data were entered into an Excel form, processed then analyzed using Statistical Package for Social Science (SPSS) version 23.
Results:
A total of 385 individuals were comprised as a sample in the study, all resides at Albaraha area in Bahri locality, most of them 47.8% aged 18–39 and only 4.9% aged more than 70 years. 52.7% of them were females and 52.5% were currently married. Most of them (57.9%) had University degree of education and 46.7% were currently employed. Only 54 of them had High fasting blood glucose and 182 had high blood pressure according to European Society of Hypertension 2023 guideline. 60% of the participant had their parent, brother, sister or their own child with a history of Diabetes and only 8.8% had no family history whatsoever of diabetes nor hypertension. People who had a positive family history of diabetes had 2 times the risk (95% CI 0.6–11.9) of having high fasting blood glucose levels compared with those who didn’t have a family history.
Conclusion:
This study illustrated that Community based screening for high blood pressure and high fasting blood glucose level can be carried out feasibly and it is highly effective in identifying undiagnosed diabetic and hypertensive individuals, especially in a low income country like Sudan in which the incidence of DM and hypertension are rising.
Genotype and haplotype analysis between ESR1 variants and breast cancer in the Bangladeshi patients: A PCR-RFLP-based genetic association study
Authors: Hossen Md. Shafiul , Aziz Md. Abdul , Barek Md Abdul , Jahan Nusrat , Afroz Nahida , Begum Mobashera , Islam Mohammad Safiqul 
Published: October 2023

Abstract
Background
Breast cancer is the most common cancer among Bangladeshi women, and its pervasiveness is increasing day by day. This case-control study attempted to determine the association between ESR1 polymorphisms and breast cancer susceptibility.
Methods
This study genotyped two ESR1 genetic variants (rs2234693 and rs9340799) in a total of 399 confirmed breast cancer patients (201 cases and 198 controls) by applying the PCR-RFLP method. SPSS software (v25.0) was used for statistical analysis, and SHEsis web program and Haploview (v4.2) were used for linkage disequilibrium and haplotype analyses, respectively.
Results
A statistically significant association of rs2234693 variant with grade 3 tumor (OR = 0.17, p = 0.0004) and rs9340799 variant with overweight (OR = 0.46, p = 0.034), infiltrating breast cancer (OR = 0.25, p < 0.0001), and positive lymph node status (OR = 2.34, p = 0.005) were observed. Again, rs2234693 variant was found to be significantly associated with breast cancer in codominant 1 (OR = 0.60, p = 0.045), codominant 2 (OR = 0.50, p = 0.021), dominant (OR = 0.56, p = 0.020), and allelic model (OR = 0.73, p = 0.028). In the case of rs9340799 variant, no significant link was observed for breast cancer. Haplotype analysis revealed a significant correlation of TA and CA haplotypes with breast cancer susceptibility (OR = 1.37, p = 0.028 and OR = 0.41, p = 0.0002, respectively). Besides, both rs2234693 and rs9340799 are found to be in strong linkage disequilibrium (D’=1.00, r2 = 0.697).
Conclusions
In this study, a significant correlation of ESR1 rs2234693 and rs9340799 genetic variants with breast cancer susceptibility has been observed. The findings of this study need to be investigated further to confirm the association.
Myosteatosis and Aortic Calcium Score on Abdominal CT as Prognostic Markers in Non- Dialysis Chronic Kidney Disease Patients
Authors: Kim Ahyun , Lee Chul-min , Kang Bo-Kyeong , Kim Mimi , Choi Jong Wook 
Published: October 2023

Abstract
We aimed to examine the relationship between abdominal computed tomography (CT)-based body composition data and both renal function decline and all-cause mortality in patients with non-dialysis chronic kidney disease (CKD). This retrospective study comprised non-dialysis CKD patients who underwent consecutive unenhanced abdominal CT between January 2010 and December 2011. CT-based body composition was measured using semiautomated method that included visceral fat, subcutaneous fat, skeletal muscle area and density, and abdominal aortic calcium score (AAS). Risk factors for CKD progression and survival were identified using logistic regression and Cox proportional hazard regression models. Survival between groups based on myosteatosis and AAS was compared using the Kaplan–Meier curve. 149 patients (median age: 70 years) were included; 79 (53.0%) patients had sarcopenia and 112 (75.2%) had myosteatosis. The median AAS was 560.9 (interquartile range: 55.7–1478.3)/m2. The prognostic factors for CKD progression were myosteatosis (odds ratio [OR] = 4.31, p = 0.013) and high AAS (OR = 1.03, p = 0.001). Skeletal muscle density (hazard ratio [HR] = 0.93, p = 0.004) or myosteatosis (HR = 4.87, p = 0.032) and high AAS (HR = 1.02, p = 0.001) were independent factors for poor survival outcomes. The presence of myosteatosis and the high burden of aortic calcium were significant factors for CKD progression and survival in patients with non-dialysis CKD.
Fibrates and Risk of Congenital Malformations: A Nationwide Cohort Study in South Korea
Authors: Kay Hee Yeon , Jang Ha Young , Kim In-wha , Oh JungMi 
Published: October 2023

Abstract

Purpose
To examine the association between maternal prescriptions for fibrates and congenital malformations in live births.
Methods
Nationwide retrospective cohort study was conducted using the data sourced from the Korean National Health Insurance database. A cohort of 756,877 completed pregnancies linked to live-born infants in 215,600 women with dyslipidemia between 2012 and 2021. The study compared data on congenital anomalies between pregnancies who were exposed to fibrates and those who were not exposed to fibrates in the first trimester. Odds ratios (OR) were calculated by a multivariable analyses using logistic regression models to adjust for potential confounders.
Results
260 pregnancies (0.12%) were exposed to fibrates during the first trimester. The prevalence of malformations in exposed offspirng was 10.77%, not significantly different compared with 9.68% in offspring of women who were not prescribed fibrates during pregnancy in patients with dyslipidemia (OR, 1.13; 95% CI, 0.75–1.70).
Conclusion
This study implies that the use of fibrates during pregnancy may be safe, as it did not show any association with congenital anomalies. However, caution is warranted due to an elevated risk associated with prolonged exposure.
The role of Helicobacter suis, Fusobacterium gastrosuis and the pars oesophageal microbiota in gastric ulceration in slaughter pigs receiving meal or pelleted feed
Authors: Taillieu Emily , Taelman Steff , De Bruyckere Sofie , Goossens Evy , Chantziaras Ilias , Steenkiste Christophe Van , Yde Peter , Hanssens Steven , De Meyer Dimitri , Criekinge Wim Van , Stock Michiel , Maes Dominiek , Chiers Koen , Haesebrouck Freddy 
Published: October 2023

Abstract
This study investigated the role of causative infectious agents in ulceration of the non-glandular part of the porcine stomach (pars oesophagea). In total, 150 stomachs from slaughter pigs were included, 75 from pigs that received a meal feed, 75 from pigs that received an equivalent pelleted feed with a smaller particle size. The pars oesophagea was macroscopically examined after slaughter. (q)PCR assays for H. suis, F. gastrosuis and H. pylori-like organisms were performed, as well as 16S rRNA sequencing for pars oesophagea microbiome analyses. All 150 pig stomachs showed lesions. F. gastrosuis was detected in 115 cases (77%) and H. suis in 117 cases (78%), with 92 cases (61%) of co-infection; H. pylori-like organisms were detected in one case. Higher infectious loads of H. suis increased the odds of severe gastric lesions (OR = 1.14, p = 0.038), while the presence of H. suis infection in the pyloric gland zone increased the probability of pars oesophageal erosions (16.4% (95%CI: 0.6–32.2%)). The causal effect of H. suis was mediated by decreased pars oesophageal microbiome diversity (-1.9% (95%CI: -5.0–1.2%)), increased abundances of Veillonella and Campylobacter spp., and decreased abundances of Lactobacillus, Escherichia-Shigella, and Enterobacteriaceae spp. Higher infectious loads of F. gastrosuis in the pars oesophagea decreased the odds of severe gastric lesions (OR = 0.8, p = 0.0014). Feed pelleting had no significant impact on the prevalence of severe gastric lesions (OR = 1.72, p = 0.28). H. suis infections are a risk factor for ulceration of the porcine pars oesophagea, probably mediated through alterations in pars oesophageal microbiome diversity and composition.
Is cone beam computed tomography accurate in predicting inferior alveolar nerve exposure during third molar extraction?
Authors: CHEN Kenan , Chen Youbai , Chen Peng , Jiang Junqi , Wang Junlin , Wang Enbo , Guo Chuanbin , Xu Xiangliang 
Published: October 2023

Abstract
Objectives
This study aims to evaluate the accuracy of cone beam computed tomography (CBCT) in predicting the exposure of inferior alveolar nerve (IAN) during complicated mandibular third molars (M3M) extraction.
Methods
115 M3Ms with canal cortical defect (CCD) signs on CBCT were extracted. Candidate variables included basic information and CCD size. Primary outcome were IAN exposure and exposed IAN size measured under endoscope. Multivariate logistic and linear regression analyses were performed to identify the association between outcome and candidate variables.
Results
85/115 M3Ms had intraoperative IAN exposure. The average length and width of exposed IAN were significantly smaller than those of CCD. Logistic regression showed that IAN exposure was significantly associated with the length of CCD on CBCT (P = 0.001). Linear regression analyses showed that the size of exposed IAN were significantly associated with the CCD length (P = 0.013) and width (P＜0.001).
Conclusions
The size of CCD on CBCT is larger than that of intraoperative exposed IAN. IAN exposure can be predicted by the length of CCD on preoperative CBCT. IAN exposure is prone to occur in cases with a length of CCD ≥ 3.4 mm on CBCT.
Clinical Relevance:
Endoscope provides the possibility to observe and record the IAN exposure directly. IAN exposure can be predicted by the length of CCD on preoperative CBCT. IAN exposure is prone to occur in cases with a length of CCD ≥ 3.4 mm on CBCT.