bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric Properties and Measurement Invariance of the Positive Youth Development Scale – Turkish Version
Authors: Yıldırım Sinan , Arslan Yunus 
Published: October 2023

In this study, we translated to Turkish and evaluated the validity, reliability, and measurement invariance for respondent sex, grade level and analysis programs the Short Form and Very Short Form of the Positive Youth Development Scale (Turkish version). We had 435 youth, aged 11–17 years, complete the Short (34 items) and Very Short (17 items) Forms of the instrument. Confirmatory factor analysis revealed that both forms had a 5-factor structure, and validity testing showed good criterion-related correlation validity between this tool and the Satisfaction with Life Scale. The Short Form had adequate reliability coefficients, but the Very Short Form lacked sufficient reliability for some dimensions. Test-retest correlations were satisfactory for both forms. While the Short and Very Short Forms showed measurement invariance across gender and grade level, CFI, NNFI (TLI), and IFI values diverged between LISREL and AMOS analysis programs. In summary, our data suggest that the Short Form is a reliable measure of positive youth development, while the Very Short Form may not be as reliable due to insufficient confidence values.
Re-revisiting the Utilities of Health States Worse than Dead: The Problem Remains
Authors: Jakubczyk Michał 
Published: October 2023

Background In valuation studies of the EQ-5D-5L instrument, the composite time tradeoff method (cTTO) is often used to elicit preferences. In cTTO, some health states are considered worse than dead (WTD) and are assigned negative utility values. However, these negative values correlate poorly with state severity, which suggests that cTTO is insufficiently sensitive. A recent threshold explanation has been offered to account for the lack of correlation: because the severity threshold beyond which a state is considered WTD differs between respondents, the correlation should be studied for individual respondents clustered by the number of WTD states. The results obtained in such a threshold approach were interpreted to disprove the insensitivity of the cTTO method. Aim To scrutinize the threshold explanation and test whether it indeed refutes the insensitivity of cTTO. Methods The study uses data from the EQ-5D-5L Polish valuation study, which includes cTTO responses from 1,510 participants, each of whom evaluated 10 EQ-5D-5L states. The correlation analysis and threshold approach are repeated to confirm the results from previous studies. The data are then modified in 2 contrasting ways. First, negative utilities are randomly reshuffled to test whether the threshold approach can capture cTTO insensitivity. Second, individual-level regressions are used to simulate negative values to ensure they correlate with severity at the individual respondent level, verifying whether the overall severity-utility correlation should be observed. Results First, reshuffling negative utilities does not change the results of the threshold approach. Hence, the threshold explanation fails to prove cTTO sensitivity. Second, when sensitivity was introduced on an individual level, a significant overall correlation between severity and negative utility arose. Conclusion cTTO is insensitive to severity for WTD states. Highlights For the composite time tradeoff method, the utility values of health states worse than dead correlate poorly with state severity, which suggests that cTTO has insufficient sensitivity. Recently, a so-called threshold explanation was offered for the lack of correlation. I show why the threshold explanation fails and why the composite time tradeoff is indeed insensitive for worse-than-dead states.
Adopting ultrasound guided PCNL in nephrolithiasis management
Authors: Neeman Binyamin B , Raisin Galia , Chertin Boris , Qadan Saeed , Kafka Ilan 
Published: October 2023

Introduction: This study aimed to evaluate the learning curve associated with the adoption of US guided PCNL and demonstrate that it can be carried out safely with results comparable to those obtained using standard PCNL. Methods: Prospective study with 65 patients who underwent PCNL between 2019 and 2020. all procedures were performed in supine position and an initial attempt to gain access to the kidney using US was made. Results: Mean procedure duration was 69.5 ± 27.8 min. Fluoroscopy was used with a mean dose of 276.68 ± 560.71 (cGycm3) and mean fluoroscopy time 40.25 ± 77.69 (s). Throughout the study there was a steady decrease in the use of fluoroscopy and amount of radiation to gain access to the kidney to only 25% at the study end. 76.5% of the patients were stone free at follow-up. Complication rate was 9.2%. Conclusions: Fluoroless US guided PCNL is safe, feasible and reproducible procedure.
Diagnostic value of FOXF1 gene promoter-methylated DNA in the plasma samples of patients with colorectal cancer
Authors: Dastafkan Zahra , Rezvani Nayebali , Amini Sabrieh 
Published: October 2023

Background Epigenetic modifications such as DNA methylation in the CpG islands of genes occur at a high rate. In this study, we measured the methylation level of the promoter region of the FOXF1 gene as a new blood biomarker for the detection of colorectal cancer in the early stages. Methods The methylation level of the promoter region of the FOXF1 gene was measured in the plasma samples of 50 colorectal cancer patients and 50 normal individuals. DNA was extracted after exposure to sodium bisulfite by the MethyLight polymerase chain reaction (PCR) method. The percentage of promoter region was measured in all samples, and statistical analysis was done using SPSS v24 software. Results The average promoter region between the plasma samples of colorectal cancer patients and healthy individuals had a significant difference ( P < 0.001). The average promoter region of the FOXF1 gene in tumor plasma samples was 7.1 and in the control samples was 0.48. The sensitivity and specificity of the sample plasma levels were 78% and 89.5%, respectively. Conclusion The promoter region value of the FOXF1 gene in plasma samples using the MethyLight PCR method had high sensitivity and specificity as a non-invasive method for colorectal cancer diagnosis. This research is the first report that has been presented regarding the investigation of FOXF1 gene methylation in plasma samples in colorectal cancer. Therefore, it is necessary to conduct more studies with larger size samples to evaluate the efficiency of the gene under investigation.
Follow the time course of inflammation caused by intraperitoneal administration of multi-wall carbon nanotubes in mice
Authors: Horie Masanori , Sugino Sakiko , Ohno Tomoki 
Published: October 2023

Objective Understand the progress of inflammation over time caused by multi-walled carbon nanotubes (MWCNT). Methods Two types of MWCNTs were administered to C57BL/6N mice via intraperitoneal administration at low and high doses (0.05 and 1.0 mg/mouse, respectively). Inflammation was evaluated until 6 months after administration based on cytokine levels and pathological observations. The abdominal cavity lavage fluid was collected and analyzed 1 week, 1, 3, and 6 month(s) after administration. IL-6 expression markedly increased 3 months after the administration of high-dose MWCNT-7. Results Notable inflammation was observed in the groups administered with one of the MWCNT, MWCNT-7. On the other hand, inflammation in another MWCNT-treated group was milder than that in the MWCNT-7-treated group. MWCNT-7 induced pronounced inflammation but did not induce tumor formation during the experimental period. Inflammation reaction is one of the most important biological responses to MWCNT. Conclusion Three months post-exposure becomes a turning point for the harmful effects of the intraperitoneally administered MWCNT-7.
A Novel Approach to Monitoring Cognitive Adverse Events for Interventional Studies Involving Advanced Dementia Patients: Insights From the Electroconvulsive Therapy for Agitation in Dementia Study
Authors: Park Soohyun , Forester Brent P. , Lapid Maria I. , Harper David G. , Hermida Adriana P. , Inouye Sharon K. , McClintock Shawn M. , Nykamp Louis , Petrides Georgios , Schmitt Eva M. , Seiner Stephen J. , Mueller Martina , Patrick Regan E. 
Published: October 2023

Objective To develop an individualized method for detecting cognitive adverse events (CAEs) in the context of an ongoing trial of electroconvulsive therapy for refractory agitation and aggression for advanced dementia (ECT-AD study). Methods Literature search aimed at identifying (a) cognitive measures appropriate for patients with advanced dementia, (b) functional scales to use as a proxy for cognitive status in patients with floor effects on baseline cognitive testing, and (c) statistical approaches for defining a CAE, to develop CAEs monitoring plan specifically for the ECT-AD study. Results Using the Severe Impairment Battery-8 (SIB-8), baseline floor effects are defined as a score of ≤5/16. For patients without floor effects, a decline of ≥6 points is considered a CAE. For patients with floor effects, a decline of ≥30 points from baseline on the Barthel Index is considered a CAE. These values were derived using the standard deviation index (SDI) approach to measuring reliable change. Conclusions The proposed plan accounts for practical and statistical challenges in detecting CAEs in patients with advanced dementia. While this protocol was developed in the context of the ECT-AD study, the general approach can potentially be applied to other interventional neuropsychiatric studies that carry the risk of CAEs in patients with advanced dementia.
Concurrent Hospice Healthcare Utilization in the Hematology/Oncology Veteran’s Affairs Patient Population
Authors: Hemrajani Anshu , Lo Shelly , Vahlkamp Alexi , Silva Abigail , Limaye Seema 
Published: October 2023

Objectives: Concurrent care is a unique care delivery system that allows patients to receive disease modifying treatments and other supportive interventions while also receiving the traditional benefits of hospice care. The objectives of our observational study were to examine health care utilization, use of cancer-directed therapies and palliative interventions, and location of death in patients enrolled in concurrent care. Methods: 72 hematology-oncology patients at the Hines Veteran’s Affairs Medical Center (VAMC) who enrolled in concurrent care from 12/2018-4/2021 were reviewed. Data were summarized with descriptive statistics including medians and percentages. Results: A minority of patients received cytotoxic chemotherapy (27.8%), immunotherapy (20.8%), palliative radiation (20.9%), blood products (11.1%), or invasive pain procedures (4.2%). Patients also used fewer cancer-directed treatments as they approached end of life (24.4% within 30 days of death compared to 13.3% within 14 days of death). Most patients died at home (62.9%) or in inpatient hospice (12.9%) as opposed to the hospital (2.9%). Conclusions: A minority of concurrent care patients received cancer-directed therapies or additional types of health care interventions despite the option to do so. Cancer-directed treatment utilization also decreased as patients approached end of life. Patients enrolled in concurrent care were able to appreciate its benefits for longer, as the average length of stay on concurrent care was nearly 3 months.
Rationalizing prescription via deprescribing in oncology practice
Authors: Raju Burnis , Chaudhary Raushan Kumar , L Ananthesh , Babu Anjana , Sandeep Ail , Mateti Uday Venkat 
Published: October 2023

Objective To provide an integrated approach for deprescribing practice in oncology setting. Data sources The data on deprescribing in oncology settings has been retrieved from the PubMed, Scopus and Google Scholar. We used “deprescribing,” “potentially inappropriate medication” and “cancer” as a keyword for the conducting general search. The articles relevant to guidelines or tools used to deprescribe in cancer care were included. Data summary The nature of cancer, its treatment strategies, adverse effects of therapy and multimorbidity impact negatively on quality of life (QoL). Further, they invite polypharmacy which puts the patient at higher risk of drug-related problems like drug interactions, adverse drug reactions and addition of potentially improper medications, etc. In older adults with cancer, the incidence of potentially inappropriate medications (PIMs) was between 41% and 52%. Over the decades, multiple strategies have been developed to assess the appropriateness of therapy. One such approach is deprescribing. OncPal and oncoSTRIP (Systematic Tool to Reduce Inappropriate Prescribing) are the cancer specific guidelines whereas BEERs criteria, Screening Tool to Alert to Right Treatment/Screening Tool of Older Person's Prescriptions criteria (START/STOPP criteria), medication appropriateness index (MAI) are the cancer nonspecific tools to identify PIM among cancer patients. Here, we provided an integrative approach and algorithm for deprescribing in oncology setting which includes patient and caregiver goals, life expectancy (LE), review of medications, determining medication appropriateness, assessment of time to benefit (TTB), symptomatic and asymptomatic care, identifying medications to cease, implementation of the plan, monitoring and reviewing. Conclusion Deprescribing in oncology setting is a novel and effective patient-centric approach to counteract the use of PIM, which helps to mitigate polypharmacy, drug–drug interactions, and adverse effects.
Assessment of adherence to routine vaccination schedules in oncology patients
Authors: Sabatino David C. , Campbell Peter , Santamala Jennifer 
Published: October 2023

Introduction Patients diagnosed with cancer are at an increased risk of infection. Vaccines remain one of the most critical public health strategies in limiting infectious diseases, with a heightened importance in cancer patients. Data across the general US population indicates that vaccine adherence rates are suboptimal across all adult vaccine schedules. This study aims to define vaccine adherence rates within the oncology population. Methods This retrospective cohort study includes adult patients with a new cancer diagnosis. Vaccine administrations for COVID-19 (SARS-CoV-2), influenza, pneumococcal, tetanus/diphtheria/pertussis (TDaP), herpes zoster (RZV), human papillomavirus (HPV), and hepatitis B (hepB) were assessed. The primary outcome was complete vaccine adherence. Results Two hundred and eighty-three oncology patients were included. The median age at diagnosis was 63 years old, and most subjects were females (60%). The two most common malignancies were gastrointestinal and breast cancer at 26.5% and 15.2%, respectively. Suboptimal vaccine adherence rates were observed across the entire oncology population. Complete adherence was observed in only 1.4% of patients. Vaccine specific adherence rates were as follows, SARS-CoV-2: 38.9%; influenza: 11.4%; pneumococcal: 12.7%; TDaP: 13.1%; RZV: 3.5%; HPV: 0%; and hepB: 34%. Among the vaccine schedules assessed, SARS-CoV-2 vaccination rates were the highest with 38.9% of patients being fully adherent and 73% receiving at least one dose. Conclusion Lower vaccine adherence rates were observed in oncology patients compared to currently published rates. Providers and pharmacists can play a role in assessing and counseling patients on the importance of vaccine adherence before chemotherapy is initiated and after a remission is obtained.
Optimal Cutoff Values of the Contact Angle of Tumor on Sonography System for Predicting Extrathyroidal Extension of Papillary Thyroid Carcinoma by Tumor Location
Authors: Beom Shin Ik , Hoon Koo Do , Sik Bae Dong 
Published: October 2023

Background: Extrathyroidal extension (ETE) significantly affects the treatment strategy for thyroid cancer. We present a new method to predict ETE of papillary thyroid carcinoma (PTC). methods: We enrolled 1 481 patients with PTCs. The ETE was classified into minimal and gross ETE. Using the novel “contact angle of the tumor on sonography” (CATS) system, we calculated optimal cutoffs for predicting ETE according to tumor location and compared the diagnostic performance to that of previous methods. Results: The optimal cutoff angles for predicting anterior minimal and gross ETE were 41.5° and 49.4°, respectively, while those for posterior ETE were 39.8° and 54.6°, respectively. The optimal cutoff angle predicting tracheal ETE was 88.0°. The diagnostic performance was comparable to that of previous methods. Conclusion: The CATS method for predicting ETE is a valuable alternative.
Andrographolide inhibits infectious bronchitis virus-induced apoptosis, pyroptosis, and inflammation
Authors: Shen Jiachen , Xu Qiuchi , Chen Lu , Chang Xinyu , Shen Ruiting , Zhao Zhenhua , Zhu Lifei , Wu Yifei , Hou Xiaolin 
Published: October 2023

Background Avian infectious bronchitis virus (IBV), a coronavirus, causes a huge economic loss to the poultry industry. Andrographolide (APL) is a compound with a variety of pharmacological properties, including antiviral and anti-inflammatory effects. In this study, APL was evaluated for antiviral activity by its anti-apoptotic, anti-pyroptosis, and anti-inflammatory effects. Methods The cytotoxicity of APL was determined by the MTT method. We investigated the therapeutic impact of APL on IBV through a plate assay. We explored that APL inhibited IBV-induced apoptosis, pyroptosis, and inflammation in HD11 cells by RT-qPCR and immunofluorescence. Also, it was verified in the clinical chicken embryo trial. Results We found that APL down-regulated apoptosis-related genes Caspase-3, Caspase-8, Caspase-9, Bax, Bid, and Bak, down-regulated pyroptosis gene DFNA5, and down-regulated inflammation-related genes (NF-κB, NLRP3, iNOS, TNF-α, and IL-1β). In addition, APL reduced the reactive oxygen species (ROS) production in cells. Finally, clinical trials showed that APL inhibited IBV-induced apoptosis, pyroptosis, and inflammation, as well as reduced the mortality and malformation of chicken embryos. Conclusions In this study, we delved into the antiviral properties of APL in the context of chicken macrophage (HD11) infection with IBV. Our findings confirm that andrographolide effectively inhibits apoptosis, pyroptosis, and inflammation by IBV infection. Furthermore, this inhibition was verified on chicken embryos in vivo. This inhibition suggests a substantial potential for APL as a therapeutic agent to mitigate the harmful effects of IBV on host cells.
Osteoporosis in the setting of rotator cuff repair: A narrative review
Authors: Daher Mohammad , Zalaquett Ziad , Fares Mohamad Y , Boufadel Peter , Khanna Akshay , Abboud Joseph A 
Published: October 2023

Osteoporosis and osteopenia are frequently found in patients undergoing shoulder surgery, especially rotator cuff repair, and it is anticipated that this link will become more common as more elderly people have operations on their shoulders. For orthopedic surgical candidates who are at high risk, preoperative screening may identify those who might benefit from early intervention and prevent any associated adverse events. The major complications include repair failure and revision surgery. Antiresorptive medication preoperatively has shown good results in vivo. However, when used in the clinical setting, the efficacy remains controversial. Surgical management may include repair augmentation and placing the anchors in the posteromedial part of the greater tuberosity. Level of evidence: IV.
Challenges and successes in implementing an integrated electronic patient record (HIVE) at the Manchester University National Health Service Foundation Trust, England: 1000+ legacy systems, 10 hospitals, one electronic patient record
Authors: Burns Mandy 
Published: October 2023

Background: The Manchester University National Health Service (NHS) Foundation Trust (MFT) is one of the largest NHS Trusts in England. Historically, the Trust has had very mixed clinical record keeping, including over 1000 individual information systems. None of these health information technology systems had the full functionality of an integrated electronic patient record (EPR). MFT evolved to its current size and complexity with a vision to improve patient care in Greater Manchester by adopting a Trust-wide EPR. The EPR “Go Live” occurred in September 2022. Aim: To describe the process of EPR integration as it reflected and impacted upon MFT’s health information management (HIM) teams. Method: MFT worked through a 2-year readiness program of work. This included technical readiness, software development and migration planning. Migration of data from the approximately 1000 systems was a major undertaking, during which access to the clinical history and ongoing operational reporting needed to be maintained. Pre-implementation requirements were outlined, a change management program was implemented, and the overall implementation was managed to tight timelines. Discussion: “Go Live” was achieved for the EPIC EPR product (HIVE) within MFT. Legacy systems are still in the process of being decommissioned and staff are transacting within HIVE. Significant changes in processes and reporting continue to be made, despite some challenges. Conclusion: The Trust delivered the single largest EPIC European “Go live.” Lessons learnt continue to be identified. The impact of what the EPR means for the HIM function is described.
Differentiating Between Three Licorice Species Using SFC-TOF/MS Analysis With Principal Component Analysis
Authors: Saito Hideki , Miyoshi Shozo , Murakami Toshiyuki , Suzuki Ryuichiro 
Published: October 2023

Objective Although the discrimination of crude drugs by metabolomics analysis using liquid chromatography–mass spectrometry (LC–MS) has been widely reported, there are few reports on natural products analysis using supercritical fluid chromatography (SFC)–MS. This study aimed to compare the results of metabolomic analysis of licorice obtained using SFC–MS and LC–MS. Methods We analyzed 14 CHCl3 extracts of licorice roots ( Glycyrrhiza glabra, G. uralensis, and G. inflata) using SFC-time-of-flight (TOF)/MS and LC-TOF/MS in conjunction with principal component analysis (PCA). The three species were assessed for discrimination based on the PCA results. The characteristic constituents of each variety were purified, and their chemical structures were elucidated using various spectroscopic analyses. Results The PCA score plots of the results of both SFC and LC classified the licorice samples into three groups. Seven compounds (six known compounds and one new phenolic compound, glyglabone) were isolated from G. glabra, five known compounds were isolated from G. uralensis, and four known compounds were isolated from G. inflata. Conclusions The 16 isolated compounds may be characteristic compounds in the three licorice species. The SFC and LC methods showed comparable results in distinguishing the three species. SFC was highly effective for directly analyzing CHCl3 extracts, reducing analysis time and organic solvent consumption by over 50% compared to the LC analysis. Thus, SFC-TOF/MS in combination with PCA can be used to differentiate between G. glabra, G. uralensis, and G. inflata.