bluuebunny/crossref_metadata_2025_split huggingface dataset:
Description of Dengue Hemorrhagic Fever Cases in Health Centers in the East Pekalongan Sub-District in 2023
Authors: Irawan Teguh , Indriyani Yulis , Angraeni Diva Alya , Amalia Putri Rika , Zahro Fatimata , Mutiafani Amelia , Yusuf Muhammad Lutfi 
Published: February 2025

In terms of public health, Dengue Hemorrhagic Fever (DHF) is a problem in Indonesia. The Aedes aegypti mosquito infected with dengue virus is the vector of dengue hemorrhagic fever (DHF). DHF is usually found in tropical climates, as vector characteristics are influenced by rainfall, temperature, and rapid movement. Data shows that Asia is the center of the most cases of dengue fever every year, and Indonesia is still one of the main transmission areas. In 2017, the dengue incidence rate in Pekalongan City was 1.44 cases per 10,000 population, and there were 44 confirmed cases in the Pekalongan City Health Center area, consisting of 18 males and 16 females. Therefore, this study aims to describe dengue hemorrhagic fever (DHF) cases at the health center in the east Pekalongan sub-district area in 2023, including the number of cases, age, gender, and time of occurrence of cases. This study uses a descriptive method in which secondary data on DHF patients recorded at the Noyontaan, Tondano, and Sukorejo health centers are obtained and then analyzed descriptively using the SPSS version 24 application. Based on the results of the research, the number of DHF cases at the Puskesmas of East Pekalongan Subdistrict in 2023 was quite high, as many as 49 cases, with the highest number of DHF cases found in the Tondano health center area. The number of DHF patients occurred in the adolescent age group of 10-18 years as many as 20 cases (40.8%) and 25 cases (51.0%) of males. The high number of DHF cases indicates the need for more intensive disease prevention and control efforts, especially in the adolescent age group, as well as paying attention to the increase in cases in certain months.
Maya Angelou's I Know Why the Caged Bird Sings: The Journey to Freedom and Empowerment
Authors: Arwa A. Khayat  , Dawla S. Alamri  
Published: February 2025

Maya Angelou's memoir, I Know Why the Caged Bird Sings (1969), demonstrates the transformative power of resistance and the complexities of being a Black woman in a racially oppressive society. This paper delves into Angelou's narrative, examining how she portrays the complexities and intersections of race and gender and their impact on Black women’s lives. The study also explores the various forms of resistance employed by Angelou and other Black women depicted in the memoir through the Black feminist perspectives of Patricia Hill Collins. This perspective provides a lens through which to thoroughly examine the themes of racism, sexism, identity, and resilience central to Angelou's work. Collins’ perspectives offer a critical and intersectional analysis of Black women's unique perspectives, experiences, and struggles. This study argues that Angelou's acts of defiance, ranging from self-expression through literature and poetry to the pursuit of education and the strength found in the community, lead to personal growth, empowerment, and liberation. The findings of this research highlight Angelou’s self-determination, acts of defiance and resistance, self-expression, and collective solidarity in the ongoing struggle against intersectional oppression and the impact on her journey of empowerment, self-healing, and liberation to become a voice that supports others’ freedom.
فاعلية برنامج تدريبي لتحسين مهارات الإدراك لدي أطفال الروضة
Authors: البروفيسور منصور بانقا  حجر محمد  , الدكتور عبد الحميد حسن حاج أمين  
Published: February 2025

هدفت الدراسة إلى التعرف على فاعلية برنامج تدريبي في تحسين مهارات الإدراك لدي أطفال الروضة, ومعرفة الفروق ذات الدلالة الإحصائية بين إجابات الأطفال، قبل تطبيق البرنامج التدريبي وبعد تطبيقه, ومعرفة الفروق ذات الدلالة الإحصائية بين إجابات الأطفال, ترجع لمتغيرات الدارسة النوع, المستوي, مستوي تعليم ولي أمر الطفل, استخدمت الدراسة المنهج شبه التجريبي, والبرنامج التدريبي والمقياس أدوات لها تمثل مجتمع الدراسة في أطفال روضات حي الملك بلدية القضارف، واتخذت الدراسة عينة قصدية تمثلت في أطفال روضة ماما صفية والبالغ عددهم (31) طفل, وتم تحليل النتائج بواسطة برنامج الحزم الإحصائية للعلوم الاجتماع (spss) وتوصلت الدراسة إلي أنه توجد فروق ذات دلالة إحصائية بين إجابات الأطفال قبل تطبيق البرنامج التدريبي وبعد تطبيقه, لصالح إجابات أطفال الروضة بعد تطبيق البرنامج, كما أنه توجد فروق ذات دلالة إحصائية بين إجابات أطفال الروضة قبل تطبيق البرنامج التدريبي وبعد تطبيقه, لصالح إجابات أطفال الروضة بالمستوي الثاني, كما أنه توجد فروق ذات دلالة إحصائية بين إجابات أطفال الروضة قبل تطبيق البرنامج التدريبي وبعد تطبيقه ترجع لمستوي تعليم ولي أمر الطفل, لصالح المستوي الجامعي لولي الأمر, و لا توجد فروق ذات دلالة إحصائية بين المتوسطات بين إجابات أطفال الروضة بعد تطبيق البرنامج ترجع لنوع الطفل.
Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions
Authors: Levina Aviva , Crans Debbie C. , Lay Peter A. 
Published: February 2025

IntroductionCatechol moieties are common in natural bioactive molecules, and their ability to bind metal ions is widely explored both naturally with siderophores and in the development of metal-based drugs. The reactivities and biology activities of a sterically hindered model catechol compound, 3,5-di-tert-butylcatechol (dtbH2) and its oxidation product 3,5-di-tert-butyl-o-quinone (dtbQ), were studied in cell culture medium to understand better the medicinal roles of this class of molecules.MethodsAnti-proliferative activities of dtbH2 and dtbQ in fresh and aged solutions of the molecules were studied in two common human cancer cell lines, T98G (glioblastoma) and A549 (lung carcinoma). Electrospray mass spectrometry and UV/Vis spectroscopy were used to study the reactivities of the molecules in buffer solutions and cell culture medium, in the presence and absence of glutathione and imidazole.Results and DiscussionThe dtbH2 and dtbQ molecules showed high anti-proliferative activity (IC50 &lt; 10 μM in 72 h assays) in T98G and A549 cell lines in the absence of added metal ions. The activity was observed when dtbH2 and dtbQ were freshly added to cell culture medium, while pre-incubation with the medium for 24 h reduced their activity 5-10-fold. This deactivation was avoided when the biological reductant, glutathione (GSH), was added to the medium at a physiologically relevant intracellular concentration (5.0 mM). These results were explained by speciation studies (UV/Vis spectroscopy and mass spectrometry) of dtbH2 and dtbQ in cell culture medium, aqueous buffers, or organic solvents in the presence or absence of GSH. These studies showed that a redox equilibrium was established between dtbH2 and dtbQ, with the latter rapidly coupling the GSH in an oxidative manner. The resultant adduct is likely to be responsible for the high toxicity of dtbH2 and dtbQ in GSH-rich cancer cells via oxygen-dependent radical chain reactions. Deactivation of dtbH2 and dtbQ in cell culture medium in the absence of GSH was due to the reactions of dtbQ with nucleophiles, such as amino acids, followed by the formation of polymeric species. The reported high anti-proliferative activity of V(V)-catecholato complexes can be explained by a combination of their efficient cellular uptake and rapid decomposition in thiol-rich intracellular environment with the formation of active V(V) and dtbH2/dtbQ adducts with thiols (mainly GSH). Slower decomposition and deactivation of the complexes was observed in thiol-poor extracellular environments. These data show that speciation in cell culture medium is crucial for the biological activity not only of metal complexes but also of their ligands when the complexes dissociates.
Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort study
Authors: Chen Jian , Huang Haixin , Zhang Ruichen , Fu Yueqiang , Jing Chunmei 
Published: February 2025

BackgroundBloodstream infection (BSI)-induced severe sepsis is a common cause of mortality, frequently resulting in septic shock and multiple organ dysfunction syndrome (MODS). This study aimed to analyze mortality risk factors and summarize pathogen characteristics associated with BSI-induced severe sepsis in the pediatric intensive care unit (PICU).MethodsThis retrospective study was conducted at a tertiary pediatric hospital between January 2015 and December 2023, encompassing children with BSI-induced severe sepsis in the PICU. Clinical characteristics, laboratory parameters, pathogen characteristics, and drug resistance profiles of the patients were collected. Clinical and laboratory indicators along with pathogen characteristics were summarized. Logistic regression analysis was employed to identify independent risk factors associated with 28-day mortality.ResultsA total of 192 patients with bloodstream infection (BSI)-induced severe sepsis were identified, with a 28-day in-hospital mortality rate of 36.98% (71/192). The incidence of septic shock (42.1% vs. 69%, P &lt; 0.001) and AKI (14% vs. 31%, P = 0.005) was significantly lower in the survival group compared to the non-survival group. In multivariate analysis, independent risk factors for 28-day mortality were the pediatric sequential organ failure assessment (pSOFA) score (OR 1.176; 95% CI: 1.046-1.321, p = 0.007) and the P/F value (OR 0.994; 95% CI: 0.991-0.997, P &lt; 0.001). Double organism growth was detected in 8 cultures, and a total of 200 pathogenic bacteria were isolated from all blood cultures. Of these, 110 strains (55.0%) were Gram-negative bacteria, 88 strains (44.0%) were gram-positive bacteria, and 2 strains (1.0%) were Candida albicans. The most commonly isolated pathogens were Staphylococcus aureus, Coagulase-negative Staphylococcus, and Escherichia coli. The detection rate of carbapenem resistance (CR) in Acinetobacter baumannii (66.7%) was higher than that in Pseudomonas aeruginosa (15.4%). The detection rates of extended-spectrum cephalosporin resistance (ECR) and fluoroquinolone resistance (FQR) in Escherichia coli (E. coli) were higher than those in Klebsiella pneumoniae.ConclusionIn the PICU, higher mortality was observed in children with BSI-induced severe sepsis who presented with elevated pSOFA scores and low P/F values. Acinetobacter baumannii exhibited the highest levels of CR and FQR, while Escherichia coli demonstrated the highest level of ECR.
Students with disabilities in higher education call for personal empowerment, equitable inclusive systems, and individualized accommodations
Authors: Bartolo Paul A. , Borg Michelle , Callus Anne-Marie , Camilleri Liberato , De Gaetano Alistair , Mangiafico Marchita , Mazzacano D'Amato Edward , Sammut Carmen , Vidal Ramona Vella , Vincent Jonathan 
Published: February 2025

IntroductionThe number of students with disabilities in higher education is increasing, but research shows that they continue to face significant challenges for equitable participation. This study aims to deepen our understanding of these challenges through the perceptions of students with disabilities themselves.MethodsParticipants were students with disabilities enrolled at the University of Malta. Data was collected through a student survey with quantitative and open-ended questions and semi-structured interviews with students on their aspirations, on how far they felt enabled to participate in the university academic and social environments, and on how useful were the individual accommodations provided for their equitable participation. The online questionnaire was completed by 51 students constituting 21% of the total relevant population, while four semi-structured interviews were held with autistic students.ResultsThe findings firstly showed that these students considered the university as mainly an opportunity for self-development but experienced significant difficulties during their transition to and at the university for developing a healthy self-identity in the ableist university environment. Secondly, students called for the teaching system to be more pedagogically effective and sensitive to diverse student needs and for their involvement in the development of appropriate facilities for students. Thirdly, they reported that individual accommodations were necessary for their equitable participation and called for less bureaucratic processing of applications, individual negotiation of accommodations, and a system for informing lecturers of students' needs.DiscussionThe study suggests that higher education institutions should listen to the concerns of students with disabilities and involve them in curricular and environmental planning. They need to create a diversity respectful ethos and socio-emotional support that promotes everyone's membership in the university community, while adopting a universal design for learning mindset that is open to the diverse needs of students and providing a smooth system of accommodations for other individual needs.
Insulin resistance and β-cell dysfunction in individuals with normal glucose tolerance but elevated 1-h post-load plasma glucose
Authors: Nie Qianwen , Jin Xue , Mu Yahui , Huang Youyuan , Dong Aimei 
Published: February 2025

ObjectiveDiabetes and its complications impose a significant burden on public health, necessitating early identification and intervention, yet current prediabetes diagnostic criteria may not fully capture all high-risk individuals. Evaluate and compare insulin resistance (IR) and β-cell dysfunction in individuals with normal glucose tolerance (NGT) and 1-hour post-load plasma glucose (1-h PG) ≥ 8.6 mmol/L versus &lt; 8.6 mmol/L, as well as prediabetes based on IFG and/or IGT.Research design and methodsThis retrospective study included individuals at risk for diabetes who underwent an Oral Glucose Tolerance Test (OGTT), classified as having NGT or prediabetes according to ADA criteria. IR and β-cell dysfunction were assessed using the Matsuda index, insulinogenic index (IGI30), and oral disposition index (DI).ResultsAmong the 9,452 participants, 37.8% had NGT, and 62.2% were IFG or IGT in OGTT. Of the NGT group, 39.2% had a 1-h PG ≥ 8.6 mmol/L, with a higher mean age (53 vs. 47 years for those with 1-h PG &lt; 8.6 mmol/L). Glucose and insulin curves showed that the NGT group with 1-h PG ≥ 8.6 mmol/L exhibited glucose profiles similar to those with isolated impaired fasting glucose (I-IFG), marked by elevated glucose, early insulin secretion impairment, and delayed insulin peaks. Older individuals (≥ 65 years) had higher glucose and a higher prevalence of abnormal 1-h PG but showed no significant differences in IR or β-cell dysfunction compared to younger individuals.ConclusionsA 1-h PG ≥ 8.6 mmol/L in individuals with NGT is associated with substantial β-cell dysfunction, highlight the value of incorporating 1-h PG measurement into diagnostic assessments for early detection of insulin secretion impairments across age groups.
Patient perspectives on acromegaly disease burden: insights from a community meeting
Authors: Shah Shruti N. , Yuen Kevin C. J. , Bonert Vivien , Huang Wenyu , Sisco Jill , Palaty Chrystal , Dancel-Manning Kristen , Agrawal Nidhi 
Published: February 2025

ObjectiveA profound mismatch between biological and symptom control in acromegaly creates a high disease burden despite achieving optimal biological control. There is a great need to learn more about the perspectives of patients living with acromegaly.MethodsAcromegaly Community hosted a virtual meeting in January 2021 and prepared a detailed report capturing participants’ input on acromegaly symptoms and current and future treatment approaches. The findings of this report are reviewed and summarized in this study.ResultsFatigue/muscle weakness (92%) and joint pain/arthritis (90%) are the two most common and troublesome symptoms reported by meeting participants. Acromegaly negatively impacts all aspects of daily living: social interaction (49%); exercise (42%); sports/recreational activities (39%); household activities (38%); attending school or job (38%); family relationships (33%); and walking (26%). Anxiety/depression is experienced by 75% of respondents. Eighty-three percent of patients underwent pituitary surgery, and over 71% of patients require medical therapy. Patients desire future improvements in medication efficacy, tolerability, and administration; mental health resources for themselves and their families; and other multimodal approaches to address their physical symptoms, specifically hunger, weight gain, muscle weakness, and joint pains.ConclusionAcromegaly patients experience significant physical and psychological burdens despite biochemical control, highlighting the need for comprehensive and patient-centered care. In particular, the impacts on activities of daily living (ADLs) and heavy psychosocial and socioeconomic burdens are striking. We advocate for periodic screening for impacted ADLs, multidisciplinary teams to proactively address these symptoms, and call for further research on under-evaluated aspects of the disease.
Association of body roundness index with cardiovascular disease in patients with cardiometabolic syndrome: a cross-sectional study based on NHANES 2009-2018
Authors: He Xiaohua , Zhu Jingling , Liang Wenfei , Yang Xiuling , Ning Weimin , Zhao Zhan , Chen Jingyi , He Qiuxing 
Published: February 2025

BackgroundCardiometabolic syndrome (CMS), marked by abdominal obesity and metabolic dysregulation, is associated with a heightened risk of cardiovascular disease (CVD). Compared to the traditional anthropometric predictors represented by body mass index (BMI) and waist circumference (WC), body roundness index (BRI) appears to provide a more accurate reflection of the abdominal fat distribution associated with metabolic diseases. Therefore, this study intends to investigate the association of BRI with the risk of CVD and its components including congestive heart failure (CHF), coronary heart disease (CHD), angina, heart attack, and stroke in patients with CMS. At the same time, we hypothesized that BRI would identify CVD better than BMI or WC.MethodsData from the 2009-2018 National Health and Nutrition Examination Survey (NHANES). Logistic regression models were mainly utilized to evaluate the relationship between BRI and CVD in patients with CMS, including smooth curve analysis, threshold effects analysis, subgroup analysis and multiple imputation. In addition, receiver operating characteristic (ROC) curves were used to assess the ability of BRI to predict CVD.ResultsThe logistic regression model showed a positive association between the BRI and CVD. The highest quartile of BRI (Q4) showing the strongest association with CVD. The smoothed curve revealed a linear relationship between BRI and CVD, but a U-shaped association between the BRI and CHF. For CVD, stratified analyses did not show significant difference between strata. For CHF, BMI interacted with the association, with BRI being associated with decreased risk of CHF in a subgroup of normal weight subjects and increased risk of CHF in a subgroup of obese subjects. The multiple imputation further confirmed the robustness of these results. Additionally, the ROC curve indicated that BRI, BMI and WC had predictive power for CVD and CHF (AUC &gt; 0.05). BRI has similar predictive power to WC but better than BMI.ConclusionsAn elevated BRI is associated with a heightened risk of CVD in patients with CMS. BRI has similar ability to predict CVD and CHF as WC, but superior to BMI.
Environmental technology’s diminishing marginal returns: a study of green patents and emission reductions in China
Authors: Yin Xiaoyu , Xu Baofeng , Li Jia , Wu Jingyi 
Published: February 2025

IntroductionDo environmental technologies always yield desirable returns? This study addresses this question through the lens of command-and-control environmental regulation. It explores the theoretical and empirical mechanisms influencing the efficacy of technology in reducing emissions, focusing on the non-linear characteristics of technological returns under equilibrium conditions.MethodsA socio-economic model integrating pollution discharge issues was developed to examine the marginal effects of emission reduction technology. Empirical validation was conducted using green patent data from Chinese listed companies (2005–2020) and pollution emissions data from various cities. Fixed effects models and generalized random forest models were employed to analyze the relationships.ResultsThe analysis revealed that technological innovation exhibits diminishing marginal returns in reducing emissions due to existing technological constraints. The results were further dissected by categorizing patents and city characteristics, shedding light on the factors influencing emission reduction effectiveness.DiscussionThe findings emphasize the importance of addressing the non-linear nature of technological innovation in environmental regulation. Policy recommendations include fostering tailored innovation strategies and supporting cities with unique characteristics to maximize technological impact on emission reduction.
Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer
Authors: Sicheng Zhao , Jingcheng Zhang , Shuo Zhang , Jiaheng Lou , Yan Cai , Xing Bai , Tao Jiang , Guangji Zhang 
Published: February 2025

ObjectiveGastric cancer is a harmful disease, the comorbidity mechanism and causality relationship between this disease and other diseases are worth studying.MethodsUsing a two-sample Mendelian Randomization method, this study revealed the potential causal effect of atrial fibrillation (AF) on gastric cancer (GC) risk by constructing a genetic instrument containing 136 AF associated SNPs. Subsequently, analysis identifies 62 AF-GC co-associated genes and constructs a protein-protein interaction network of key genes. High-throughput sequencing data were further used to analyze the association between the two and their impact on the survival outcome of gastric cancer.ResultsThe results showed that AF was negatively associated with gastric cancer, and further analysis revealed that this relationship was independent of GC risk factors such as chronic gastritis, Helicobacter pylori infection, and alcohol consumption. Enrichment analysis reveals associations of key genes with pathways related to cardiovascular disease, inflammatory gastrointestinal diseases, and tumorigenesis. Through single-cell sequencing data analysis, fibroblast subpopulations associated with the key gene set are identified in GC, showing significant correlations with cancer progression and inflammation regulation pathways. Transcription factor analysis and developmental trajectory analysis reveal the potential role of fibroblasts in GC development. Finally, prognosis analysis and gene mutation analysis using TCGA-STAD data indicate an adverse prognosis associated with the key gene set in GC.ConclusionThis study provides new insights into the association between AF and GC and offers novel clues for understanding its impact on the pathogenesis and therapeutic strategies of GC.