bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Childhood Education Attendance and Students’ Later Outcomes in Europe
Authors: Del Boca Daniela , Monfardini Chiara , See Sarah Grace 
Published: October 2023

Abstract
The importance of investments in early childhood education (ECE) has been widely documented in the literature. Among the benefits, particularly for children from disadvantaged backgrounds, is its potential to mitigate educational inequality. However, some evidence also suggests that the positive effects of ECE on later outcomes tend to dissipate over time, leaving children who attended such programmes no better off academically than those who did not. This paper studies the relationship between students’ years spent in ECE, from 0 to before starting primary school, and the results of their educational assessment outcomes at age 15. Using PISA survey data for 14 European countries from 2015 to 2018, we conduct a cross-country comparison of student performance in reading, mathematics, and science, correlating the results to the duration of ECE attendance. Our findings show that duration in ECE is associated with better assessments at age 15, but that the benefit is nonlinear and peaks at 3–4 years of attendance. Gender and migration background are associated with student performance on the assessments; but we don’t find evidence of heterogeneity in the relationship between ECE duration and test outcomes based on gender and migration background. Instead, we document differential effects of ECE duration according to age of entry to ECE, mother’s education, and the type of educational system attended.
Ecophysiology of Kuwaiti macroalgae with special emphasis on temperature and salinity tolerance related to the conditions at desalination plant outfalls
Authors: Hajiya Hasan Amal H. , Al-Bader Dhia A. , Woodward Steve , Peters Akira F. , Küpper Frithjof C. 
Published: October 2023

Abstract
Brine discharged from seawater desalination plants impacts marine life by exposure to increased salinity and, in some cases, temperature. However, the responses of individual species to such stress remains poorly known yet their understanding is essential for assessing and predicting the impacts of seawater desalination plants. In this study, unialgal cultures obtained by the germling emergence method of 34 taxa representative of the Rhodophyta, Chlorophyta and Phaeophyceae seaweeds in the Arabian Gulf, and isolated from the vicinity of two large desalination plants in Kuwait, were subjected to increased temperature and salinity under experimental conditions in the laboratory. The dataset is complemented by measurements of seawater temperature and salinity obtained at increasing distances from the outfalls of desalination plants and along the Kuwaiti coastline including from two pristine areas, Boubiyan and Fintas. Chlorophyta, especially Ulva spp., and Phaeophyceae displayed remarkable tolerance against hypersaline and thermal stress, suggesting that this group can cope better with adverse environmental conditions. Members of the Rhodophyta were considerably more sensitive to temperature increases.
Differences between the wild-type and cultivated Gracilariopsis lemaneiformis revealed by quantitative proteome and gene expression profiling analysis
Authors: Ying Xiao , Chen Wenkang , Chen Qionglin , Zhang Xiaoqian , Xu Nianjun , Sun Xue 
Published: October 2023

Abstract
The seaweed Gracilariopsis lemaneiformis is widely cultivated in the southern and northern coasts of China, and is mainly used for agar extraction and abalone feed. The cultivated strain of G. lemaneiformis 981 has various advantages over the wild type such as growth rate and high-temperature tolerance. Therefore, it is necessary to investigate the differences between the wild-type and cultivated G. lemaneiformis. Here, 648 up-regulated and 837 down-regulated proteins were screened using the isobaric tags for relative and absolute quantitation (iTRAQ) technique, and these differentially expressed proteins (DEPs) were concentrated in the pathways including “Ribosome”, “Photosynthesis-antenna proteins”, “alpha-Linolenic acid metabolism”, and “Phenylpropanoid biosynthesis”. The most prominent pathway was “Ribosome”, namely, 116 out of 119 ribosome-associated proteins were up-regulated in G. lemaneiformis 981 compared to the wild type. Subsequently, multiple reaction monitoring (MRM) validated the credibility of the iTRAQ results. Finally, “Phenylpropanoid biosynthesis” and “Photosynthesis-antenna proteins” pathways were also found to be significantly changed in G. lemaneiformis 981 validated by gene expression profiling analysis. Altogether, these results, in combination with chlorophyll fluorescence parameters, unveiled the possible mechanism of differences in growth and anti-abiotic stresses between the wild-type and cultivated G. lemaneiformis, which would provide a reference for breeding of excellent seaweeds.
Finding small molecular compounds to decrease trimethylamine oxide levels in atherosclerosis by virtual screening
Authors: Luo Jiaxin , Zhang Aoqi , Yao Yuan , Yuan Jun 
Published: October 2023

Abstract
The intestinal microbial metabolite trimethylamine oxide (TMAO) affects the formation and development of atherosclerosis (AS). The design and development of an effective targeted drug to reduce serum TMAO levels may provide new avenues for inhibiting AS morbidity. Target genes that may elevate TMAO levels in patients with AS were explored using bioinformatics, virtual screening, and molecular dynamics (MD). We expected these genes to indicate potential TMAO inhibitors. Of these genes, hFMO3 was responsible for increasing TMAO levels. Four small-molecule compounds (SMC-1, SMC-2, SMC-3, and SMC-4) with the lowest binding energy and CGenFF penalty < 10 were connected to the main binding pocket of hFMO3 by hydrogen and/or cation–pi interactions. A 100 ns MD simulation showed that the four systems quickly reached equilibrium. The root mean square deviation of all four small-molecule compounds was less than 0.35 nm, that of the four ligand complexes was less than 0.40 nm, and the average deviations of each amino acid residue from the reference position over time did not differ. Molecular mechanics Poisson–Boltzmann surface area analyses showed that SMC-2, SMC-3, and SMC-4 bound very well to hFMO3, and the energy contribution of the key residues LEU40 and GLU32 was more remarkable in SMC-2, SMC-3, and SMC-4. These four small-molecule compounds may be useful as targeted drugs to reduce serum TMAO levels, inhibiting atherosclerosis formation.
A Conjecture on H
3(1) for Certain Starlike Functions
Authors: Verma Neha , Kumar S. Sivaprasad 
Published: October 2023

ABSTRACT
We prove a conjecture concerning the third Hankel determinant, proposed by Kumar and Kamaljeet in [A cardioid domain and starlike functions, Anal. Math. Phys. 11 (2021), Art. 54], which states that |H
3(1)| ≤ 1/9 is sharp for the class

S
℘
*

=

{

z

f
′

(
z
)

/
f

(
z
)

≺
φ

(
z
)

:
=
1
+
z

e
z

}

. In addition, we also establish bounds for sixth and seventh coefficient, and |H
4(1)| for functions in

S
℘
*

. The general bounds for two and three folds symmteric functions related with the Ma-Minda classes

S
*

(
φ
)

of starlike functions are also obtained.
On the Existence of Bi-Lipschitz Equivalent Metrics in Semimetric Spaces
Authors: Caruso Andrea Orazio , Palmisano Vincenzo 
Published: October 2023

ABSTRACTWe provide an overview of the known problem on the existence of a bi-Lipschitz equivalent metric with respect to a given quasi-ultrametric, revisiting known results and counterexamples in an unified approach based on the existence of a relaxed polygonal inequality. We present new proofs and characterizations of classical results using different techniques.
Flexural performance of a new type of slightly curved arc HRB400 steel bars reinforced one-way concrete slabs
Authors: Zhuang Mei-Ling , Gao Li , Zhu Fangzhi , Sun Chuanzhi , Zhu Hanbo , Yu Changrong , Qiao Yan 
Published: October 2023

Abstract
In the present study, a new type of slightly curved arc HRB400 steel bars (SCAHSs) was proposed to solve the problem of temperature-induced stress loss in mass concrete structures without cutting off steel bars. The flexural performance of SCAHSs and straight HRB400 steel bars reinforced one-way concrete slabs were first experimentally investigated. Then, the effects of the shape and dimension of SCAHSs on the distribution and width of concrete cracks were analyzed and discussed. Subsequently, the synergistic tensile work characteristics between SCAHSs and concrete were presented. Finally, equations for the bearing capacity and allowable crack widths for SCAHSs in hydraulic massive structures were proposed. The test results indicated that after replacing the straight steel bars in the concrete slab with SCAHSs, the crack width of the concrete slabs increased, with the maximum crack width at the bottom of the concrete slabs increasing by a factor of 1.2–1.4. As the rise-span ratio of SCAHSs increased, the flexural stiffness of SCAHSs reinforced concrete slab decreased slightly, but the deflection increased. The allowable crack widths of SCAHSs reinforced concrete slabs under environment categories I, II, and III were 0.20, 0.17, and 0.12 mm, respectively.
Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety
Authors: Rosário Bárbara dos Anjos , Lemes Jéssica Alves , de Lima Maria Paula , Ribeiro Daniel Araki , Viana Milena de Barros 
Published: October 2023

Abstract
Social anxiety disorder (SAD) is a debilitating disorder, characterized by fear and anxiety in social situations. Evidence suggests that the levels of SAD are rising, in particularly after the COVID-19 pandemic. Serotonin and noradrenaline reuptake inhibitors and cognitive-behavioral therapy are effective treatments for SAD. Nevertheless, a significant number of patients do not respond well to these therapeutic options. During the last years, Cannabis and cannabinoid-containing products have been investigated for the treatment of different neuropsychiatric disorders. Nevertheless, their efficacy for the treatment of anxiety disorders is still a matter of debate. The purpose of this review was to investigate subjective, behavioral, and neurobiological effects of Cannabis and cannabinoids in social anxiety and SAD. A search in the PubMed database for articles published between the years of 2003–2023 was conducted. One hundred and seventeen (117) original studies were identified. After the exclusion criteria, eighteen (18) studies were selected. The studies investigated the effects of the cannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in patients or healthy volunteers submitted to tasks that assessed social anxiety. Results showed that CBD decreases social anxiety, producing an inverted U-shaped curve, with anxiety measurements being reduced at intermediate doses administered orally (300–600 mg), but not at lower or higher doses. THC either reduces (lower doses, 6–7.5 mg) or increases (higher doses) social anxiety measurements. CBD attenuates the anxiogenic effects of THC. The effects of THC and CBD in anxiety are associated to the modulation of fronto-limbic regions. Further clinical trials, conducted with male and female patients and larger cohorts are still necessary to consolidate these results.
Quantifying Peripheral Modulation of Olfaction by Trigeminal Agonists
Authors: Genovese Federica , Xu Jiang , Tizzano Marco , Reisert Johannes 
Published: October 2023

In the mammalian nose, two chemosensory systems, the trigeminal and the olfactory mediate the detection of volatile chemicals. Most odorants are able to activate the trigeminal system, and vice versa, most trigeminal agonists activate the olfactory system as well. Although these two systems constitute two separate sensory modalities, trigeminal activation modulates the neural representation of an odor. The mechanisms behind the modulation of olfactory response by trigeminal activation are still poorly understood. We addressed this question by looking at the olfactory epithelium (OE), where olfactory sensory neurons (OSNs) and trigeminal sensory fibers co-localize and where the olfactory signal is generated. Our study was conducted in a mouse model. Both sexes, males and females, were included. We characterize the trigeminal activation in response to five different odorants by measuring intracellular Ca2+changes from primary cultures of trigeminal neurons (TGNs). We also measured responses from mice lacking TRPA1 and TRPV1 channels known to mediate some trigeminal responses. Next, we tested how trigeminal activation affects the olfactory response in the olfactory epithelium using electro-olfactogram (EOG) recordings from wild-type (WT) and TRPA1/V1-knock out (KO) mice. The trigeminal modulation of the olfactory response was determined by measuring responses to the odorant, 2-phenylethanol (PEA), an odorant with little trigeminal potency after stimulation with a trigeminal agonist. Trigeminal agonists induced a decrease in the EOG response to PEA, which depended on the level of TRPA1 and TRPV1 activation induced by the trigeminal agonist. This suggests that trigeminal activation can alter odorant responses even at the earliest stage of the olfactory sensory transduction.SIGNIFICANCE STATEMENTMost odorants reaching the olfactory epithelium (OE) can simultaneously activate olfactory and trigeminal systems. Although these two systems constitute two separate sensory modalities, trigeminal activation can alter odor perception. Here, we analyzed the trigeminal activity induced by different odorants proposing an objective quantification of their trigeminal potency independent from human perception. We show that trigeminal activation by odorants reduces the olfactory response in the olfactory epithelium and that such modulation correlates with the trigeminal potency of the trigeminal agonist. These results show that the trigeminal system impacts the olfactory response from its earliest stage.
Evaluation of the correlation between fetuin-B levels and essential hypertension: a cross-sectional study
Authors: Gao Tao , Liu Rui , Li Chunli , Chu Xinglin , Guo Qiao , Ke Dazhi 
Published: October 2023

Background
Fetuin-B, a cytokine that regulates lipid metabolism, has recently been linked to cardiovascular diseases such as coronary heart disease. In this study, we discussed the relationship between fetuin-B and essential hypertension.

Method
A bioinformatics analysis of fetuin-B was performed. A total of 206 with essential hypertension and 180 age- and-sex-matched healthy subjects were enrolled. Plasma fetuin-B, endothelin 1 (ET-1), nitric oxide (NO), and adiponectin (ADI) levels were measured using ELISA kits.

Results
Bioinformatics analysis has revealed that fetuin-B plays an important role in pathways such as lipid metabolism. Compared with healthy subjects, serum fetuin-B levels in patients with essential hypertension were significantly increased. Correlation analysis showed that the serum fetuin-B level was positively correlated with systolic blood pressure (SBP), diastolic blood pressure, body mass index, fat percentage in vivo, waist–hip ratio, intima–media thickness, low-density lipoprotein cholesterol (LDL-C), glutamyltranspeptidase, alanine transaminase, albumin, fasting blood glucose (FBG), glycated hemoglobin, and ET-1 in the overall study subjects (all P < 0.05) and negatively correlated with HDL-C, ADI, and NO (all P < 0.05). Multivariate linear regression analysis showed that SBP, FBG, LDL-C, ADI, and ET-1 were independent factors affecting serum fetuin-B. A binary logistic regression analysis showed that fetuin-B was an independent risk factor for primary hypertension (odds ratio: 1.060, 95% CI: 1.034–1.086, P < 0.001). Receiver operating characteristic curve analysis was used to evaluate the predictive value of fetuin-B for primary hypertension, and the optimal cutoff point was 83.14 μg/mL (sensitivity 77.4%, specificity 63.3%) (area under the curve) = 0.7738, 95% CI 0.7276–0.8200, P < 0.001).

Conclusion
Elevated fetuin-B levels are associated with an increased risk of essential hypertension.
The Impact of Banking Competition on Bank Financial Stability: Evidence from ASEAN 5 Countries
Authors: Ekananda Mahjus 
Published: October 2023

In the era of the global economy, increasing banking competition will encourage an increase in banking transactions and activities. Banking transactions and activities will affect a country's financial stability. The purpose is to obtain the nonlinear effect of banking competition on financial stability at a specific regime. Previous research assumed that this impact applies to every economic regime. The impact of banking competition on financial stability can change at certain regime levels. Nonlinear impact occurs according to the regime. The method is based on a nonlinear threshold regression model. The researchers obtained the data from five ASEAN countries. The findings of this research are in-depth information about the financial system stability model. Analysis of the effect of variance supports the inconsistency of the effects found by several previous researchers. Practical implications are aimed at policymakers to make different decisions at the GDP level, CAR and Liquidity. The economic regime in each country is different, so this analysis is constructive for policymakers to see the conditions of banking competition and financial system stability at a certain regime level. The originality article systematically offers an analysis that assumes the effect can change at a certain regime level.JEL Classification: E5, G15, G01, G32, C24
Impact of Raw Material Export Restrictions on Employment: Evidence from Panel Data
Authors: Setiono Dede 
Published: October 2023

The extractive industry typically contributes limited direct employment in host countries, prompting some nations to consider export restrictions on raw materials to enhance domestic job opportunities. However, scholarly opinions on the efficacy of these policies vary widely. This study addresses this gap by utilizing an extensive dataset spanning over a decade and encompassing diverse countries. Employing a fixed-effect Ordinary Least Square (OLS) regression model with panel data from 74 countries from 2009 to 2021, this paper shows that raw material export restrictions do not affect employment rates. This fact challenges the prevailing notion that export restrictions inherently boost domestic employment. Consequently, a more comprehensive strategy, including economic diversification, technological investment, and alternative job creation measures alongside export controls, is essential to effectively address employment challenges within the extractive sector.JEL Classification: F1, J2, O1
Maternal Pertussis Vaccination, Infant Immunization, and Risk of Pertussis
Authors: Regan Annette K. , Moore Hannah C. , Binks Michael J. , McHugh Lisa , Blyth Christopher C. , Pereira Gavin , Lust Karin , Sarna Mohinder , Andrews Ross , Foo Damien , Effler Paul V. , Lambert Stephen , Van Buynder Paul 
Published: October 2023

OBJECTIVES
Following the introduction of jurisdictional maternal pertussis vaccination programs in Australia, we estimated maternal vaccine effectiveness (VE) and whether maternal pertussis vaccination modified the effectiveness of the first 3 primary doses of pertussis-containing vaccines.

METHODS
We conducted a population-based cohort study of 279 418 mother–infant pairs using probabilistic linkage of administrative health records in 3 Australian jurisdictions. Infants were maternally vaccinated if their mother had a documented pertussis vaccination ≥14 days before birth. Jurisdictional immunization records were used to identify receipt of the first 3 infant doses of pertussis-containing vaccines. Infant pertussis infections were identified using notifiable disease records. VE was estimated using Cox proportional hazard models.

RESULTS
Pertussis was administered during 51.7% (n = 144 429/279 418) of pregnancies, predominantly at 28–31 weeks’ gestation. VE of maternal pertussis vaccination declined from 70.4% (95% confidence interval [CI], 50.5–82.3) among infants &lt;2 months old to 43.3% (95% CI, 6.8–65.6) among infants 7–8 months old and was not significant after 8 months of age. Although we observed slightly lower VE point estimates for the third dose of infant pertussis vaccine among maternally vaccinated compared with unvaccinated infants (76.5% vs 92.9%, P = .002), we did not observe higher rates of pertussis infection (hazard ratio, 0.70; 95% CI, 0.61–3.39).

CONCLUSIONS
Pertussis vaccination near 28 weeks’ gestation was associated with lower risk of infection among infants through 8 months of age. Although there was some evidence of lower effectiveness of infant vaccination among maternally vaccinated infants, this did not appear to translate to greater risk of disease.
Der Tod und der Blick
Authors: Kovács Adorján 
Published: October 2023

AbstractThe Hungarian poet Sándor Petőfi was neither the nature boy oriented only to folk song nor the proto-socialist revolutionary as the German reception in the 19th and 20th centuries saw him. The short poems of the “Clouds” cycle published in 1846, for example, are aphoristically pointed pessimistic meditations. In the piece presented (Itt állok a rónaközépen…, Here I stand in the middle of the plain…), the speaker recognises the deep gulf between himself and “the other”. Both a death symbolism can be attributed to “the other” and Sartre's phenomenology of the gaze can be applied to his perception, revealing a complexity of Petőfi's poetry that suggests its reassessment.