bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Situ Sodium Chloride Cross‐Linked Fish Skin Collagen Scaffolds for Functional Hemostasis Materials
Authors: Chang Peng , Guo Kai , Li Shijie , Wang Hongtao , Tang Mingqiang 
Published: November 2023

AbstractCurrent fish collagen hemostasis for wound healing products is commonly obtained by electrospinning or artificial cross‐linking fish collagen fibers which lacks mechanical properties, and biofunctions. Here, a new bio‐active fish skin scaffold (FSS) is shown using in situ cross‐linked scaleless freshwater fish skin adding adipose‐derived stem cells (ASCs)‐produced exosomes for hemostasis and wound healing. The structure, pore size, and the thickness of FSS is studied by swelling test, Fourier‐transform infrared (FT‐IR) spectra, scanning electron microscope (SEM) images, and histological analysis. The biofunctions of the FSS are also tested in vitro and in vivo. FSS keeps two functional layers: The dermis layer collagen forms a sponge like structure after swelling and in situ cross‐linking treatments. The pore size of the FSS is ≈152 ± 23.54 µm, which is suitable for cells growing, angiogenesis and ASCs exosomes accelerate wound healing. The fat‐rich epidermis layer can keep the wound moisty and clean before completely healed. In vitro and in vivo experimental results indicate that FSS+Exosomes enhances rat skin cavity wound healing. In situ sodium chloride cross‐linked FSS+Exosomes provides a new strategy as functional hemostatic dressing scaffold for wound healing.
Using Decellularized Magnetic Microrobots to Deliver Functional Cells for Cartilage Regeneration
Authors: Huang Hanjin , Li Junyang , Wang Cheng , Xing Liuxi , Cao Hui , Wang Chang , Leung Chung Yan , Li Zongze , Xi Yue , Tian Hua , Li Feng , Sun Dong 
Published: November 2023

AbstractThe use of natural cartilage extracellular matrix (ECM) has gained widespread attention in the field of cartilage tissue engineering. However, current approaches for delivering functional scaffolds for osteoarthritis (OA) therapy rely on knee surgery, which is limited by the narrow and complex structure of the articular cavity and carries the risk of injuring surrounding tissues. This work introduces a novel cell microcarrier, magnetized cartilage ECM‐derived scaffolds (M‐CEDSs), which are derived from decellularized natural porcine cartilage ECM. Human bone marrow mesenchymal stem cells are selected for their therapeutic potential in OA treatments. Owing to their natural composition, M‐CEDSs have a biomechanical environment similar to that of human cartilage and can efficiently load functional cells while maintaining high mobility. The cells are released spontaneously at a target location for at least 20 days. Furthermore, cell‐seeded M‐CEDSs show better knee joint function recovery than control groups 3 weeks after surgery in preclinical experiments, and ex vivo experiments reveal that M‐CEDSs can rapidly aggregate inside tissue samples. This work demonstrates the use of decellularized microrobots for cell delivery and their in vivo therapeutic effects in preclinical tests.
Multiscale Design for Robust, Thermal Insulating, and Flame Self‐Extinguishing Cellulose Foam
Authors: Sun Hao , Zheng Dingyuan , Zhu Yeling , Zhu Penghui , Ye Yuhang , Zhang Yifan , Yu Zhengyang , Yang Pu , Sun Xia , Jiang Feng 
Published: November 2023

AbstractCellulose foams are in high demand in an era of prioritizing environmental consciousness. Yet, transferring the exceptional mechanical properties of cellulose fibers into a cellulose network remains a significant challenge. To address this challenge, an innovative multiscale design is developed for producing cellulose foam with exceptional network integrity. Specifically, this design relies on a combination of physical cross–linking of the microfibrillated cellulose (MFC) networks by cellulose nanofibril (CNF) and aluminum ion (Al3+), as well as self‐densification of the cellulose induced by ice‐crystal templating, physical cross–linking, solvent exchange, and evaporation. The resultant cellulose foam demonstrates a low density of 40.7 mg cm–3, a high porosity of 97.3%, and a robust network with high compressive modulus of 1211.5 ± 60.6 kPa and energy absorption of 77.8 ± 1.9 kJ m−3. The introduction of CNF network and Al3+ cross–linking into foam also confers excellent wet stability and flame self‐extinguish ability. Furthermore, the foam can be easily biodegraded in natural environments , re‐entering the ecosystem's carbon cycle. This strategy yields a cellulose foam with a robust network and outstanding environmental durability, opening new possibilities for the advancement of high‐performance foam materials.
Anisotropic Multitentacle Janus Particles Synthesized by Selective Asymmetric Growth
Authors: Long Yingchun , Wu Qiuhua , Jiang Chao , Zhang Guolin , Liang Fuxin 
Published: November 2023

AbstractAnisotropic colloidal particles with asymmetric morphology possess functionally rich heterogeneous structures, thus offering potential for intricate superstructures or nanodevices. However, it is a challenge to achieve controlled asymmetric surface partitioned growth. In this work, an innovative strategy is developed based on the selective adsorption and growth of emulsion droplets onto different regions of object which is controlled by wettability. It is found that the emulsion droplets can selectively adsorb on the hydrophilic surface but not the hydrophobic one, and further form asymmetric tentacle by the interfacial sol–gel process along its trajectory. Janus particles with an anisotropic shape and multitentacle structure are achieved via integration of emulsion droplet (soft) and seed (hard) templates. The size and number of tentacles exhibit tunability mediated by soft and hard templates, respectively. This general strategy can be expanded to a variety of planar substrates or curved particles, further confirming the correlation between tentacle growth and Brownian motion. Most interestingly, it can be employed to selectively modify one region of surface partitioned particles to achieve an ABC three‐component Janus structure.
Engineering Zinc–Organic Frameworks‐Based Artificial Carbonic Anhydrase with Ultrafast Biomimetic Centers for Efficient Hydration Reactions
Authors: Li Lin , Xu Wenjie , Wu Zihe , Geng Wei , Li Shuang , Sun Shudong , Wang Mao , Cheng Chong , Zhao Changsheng 
Published: November 2023

AbstractConstructing effective and robust biocatalysts with carbonic anhydrase (CA)‐mimetic activities offers an alternative and promising pathway for diverse CO2‐related catalytic applications. However, there is very limited success has been achieved in controllably synthesizing CA‐mimetic biocatalysts. Here, inspired by the 3D coordination environments of CAs, this study reports on the design of an ultrafast ZnN3‐OH2 center via tuning the 3D coordination structures and mesoporous defects in a zinc–dipyrazolate framework to serve as new, efficient, and robust CA‐mimetic biocatalysts (CABs) to catalyze the hydration reactions. Owing to the structural advantages and high similarity with the active center of natural CAs, the double‐walled CAB with mesoporous defects displays superior CA‐like reaction kinetics in p‐NPA hydrolysis (V0 = 445.16 nM s−1, Vmax = 3.83 µM s−1, turnover number: 5.97 × 10−3 s−1), which surpasses the by‐far‐reported metal–organic frameworks‐based biocatalysts. This work offers essential guidance in tuning 3D coordination environments in artificial enzymes and proposes a new strategy to create high‐performance CA‐mimetic biocatalysts for broad applications, such as CO2 hydration/capture, CO2 sensing, and abundant hydrolytic reactions.
An international empirical study on the relationship between decision‐making information complexity and resource‐based view in small and medium‐sized enterprises
Authors: Sipos Norbert , Bányai Edit , Venczel‐Szakó Tímea 
Published: November 2023

AbstractThis study contributes to the topic of small and medium‐sized enterprise (SME) decision‐making peculiarities from a resource‐based view (RBV). It provides empirical evidence on the relationship between the decision of SMEs and a variety of information sources. We analysed a comprehensive dataset drawn from the Global Competitiveness Project on SMEs' competitiveness, including cross‐sectional data of 784 businesses from eight countries. The extent of information used by SMEs is positively affected by the intensity of competition, networking and the existence of formal and informal relationships, the higher level of innovation activity and a more complex compensation system. We could only partially support the fact that the amount of information used by SMEs in decision‐making is positively influenced by their marketing practices. The SME leaders should consider the fact that their business is much smaller than their potential benchmarking counterparts, and a mere imitation of decision‐making‐related information sources is not necessarily leading to the desired outcome.
Nutrition and Hydration
Authors: Roigk Patrick , Graeb Fabian , Geirsdóttir Ólöf Guðný , Bell Jack 
Published: November 2023

AbstractNutrition and hydration are fundamental aspects of healthcare, especially in the care of older people, particularly those in hospitals or in long-term care facilities. Worldwide, nurses are ‘best-placed’ coordinators of interdisciplinary nutritional management and care processes. Even so, it is essential that nurses collaborate with other healthcare specialists as an interdisciplinary team to provide high-quality care that reflects patients’ needs for assessment, intervention, and health promotion. When an interdisciplinary team work collaboratively, care is more successful, improves patient outcomes, and reduces the risk of in-hospital and long-term mortality.The care process begins with screening and monitoring of the nutritional status and fluid intake of all older people within 24 h of admission. In the case of positive screening, comprehensive assessment and involvement of other team members should undertake to understand the underlying problem. Appropriate food and appealing meals, snacks, and drinks should be available and offered with recommended amounts of energy, protein, vitamins, minerals (particularly calcium), and water. This should be complemented with supplementary drinks if intake is not adequate. The prescription of vitamin D and calcium should be discussed.Patient-centred and evidence-based information should provide and interventions in the case of end-of-life care should be appropriate discussed. Educating, informing, and involving patients and families increases their level of health literacy. Malnutrition and/or dehydration management should be included in the discharge plan.The aim of this chapter is to increase awareness of nurses’ responsibility, within a multidisciplinary team, for assessment and intervention of nutrition and hydration, examine the issues pertaining to nutrition and fluid balance in older people and outline the nature, assessment and interventions relating to malnutrition and dehydration.
Orthogeriatric Care in the Emergency and Perioperative Setting
Authors: Jensen Charlotte Myhre , Skúladóttir Sigrún Sunna , Palm Henrik , Rogmark Cecilia 
Published: November 2023

AbstractThis chapter explores the perioperative care of older people with significant fragility fractures requiring orthogeriatric care, with a focus on hip fracture as the most common of these injures. Surgery is the preferred treatment for most hip fractures. Perioperative care concerns the pre-, intra- and post-operative phase of the surgery. Principles of care and management include all fundamental aspects of care as well as specialised interventions for older people with a focus on prevention and recognition of complications.The care of the orthogeriatric patient following hip fracture and subsequent surgery presents significant challenges for the healthcare team. Assessment and subsequent care are best provided by effective interdisciplinary team working based on sound orthogeriatric principles. Nurses are often not only the caregivers, but also the coordinators of that care, and need to understand different types of hip fracture and their management so that they can deliver evidence-based acute and perioperative care to patients based on each person’s specific needs.Acquiring a hip fracture is experienced as a life-changing event with severe and frightening consequences for the individual. Although physical care attracts the most attention, patients’ existential worries and concerns must be considered as achieving good outcomes in rehabilitation after a hip fracture requires significant motivation and effort from the person.The aim of this chapter is to outline the fundamental care principles across the three perioperative phases. Effective evidence-based nursing care is crucial in optimising patient outcomes following hip fracture. Even once the patient has recovered from surgery, there remains the need to comprehensively prepare them for discharge.
Early Mobilisation and Exercise After Fragility Fracture
Authors: Kristensen Morten Tange , Keene David J. , Queirós Carmen 
Published: November 2023

AbstractThe aim of this chapter is to promote the role of the nurse and other practitioners in patients’ early mobilisation and exercise after fragility fractures. The importance of early mobilisation and exercise is highlighted, along with practical information on assessment, pain and weight bearing and tips on how to facilitate early mobilisation. There is a focus on early mobilisation after hip fracture as this is the most common significant fragility fracture requiring hospitalisation and surgery. However, many of the issues covered are in common with other types of fragility fracture.
Marrow stimulation procedures for high‐grade cartilage lesions during surgical repair of medial meniscus root tear yielded suboptimal outcomes, whilst small lesions showed surgical eligibility
Authors: Moon Hyun‐Soo , Jung Min , Choi Chong‐Hyuk , Yoo Je‐Hyun , Nam Bum‐Joon , Lee Seung‐Hun , Shin Seung‐Hwan , Kim Dong‐Ki , Kim Sung‐Hwan 
Published: November 2023

AbstractPurposeTo investigate the surgical outcomes of arthroscopic pull‐out repair for medial meniscus root tear (MMRT) combined with the marrow stimulation procedures (MSP) for accompanying high‐grade cartilage lesions.MethodsPatients who underwent arthroscopic pull‐out repair for MMRT between 2010 and 2019 were retrospectively reviewed. Patients who had at least 3 years of follow‐up were included and classified into two groups according to whether MSP (microfracture or microdrilling) were performed on cartilage lesions in the medial tibiofemoral joint (group 1, patients with International Cartilage Repair Society [ICRS] grade 0–3a lesions and did not undergo MSP; group 2, patients with ICRS grade 3b–3d lesions and underwent MSP). Comparative analyses, including non‐inferiority trials, were conducted between groups for subjective and objective outcomes. In addition, group 2 was further divided into two subgroups according to cartilage lesion size and compared with group 1 (group S, ≤ 2.0 cm2; group L, > 2.0 cm2).ResultsA total of 94 patients were included (group 1, 68 patients; group 2, 26 patients). There were no significant differences in clinical scores at postoperative 3 years and final follow‐up between groups 1 and 2, but group 2 failed to satisfy the non‐inferiority criteria compared to group 1 overall. In objective outcomes, group 2 did not meet the non‐inferiority criteria for the rate of osteoarthritis progression compared to group 1, and it also showed a significantly higher proportion of high‐grade osteoarthritis at final follow‐up (P = 0.044) and a higher degree of osteoarthritis progression than group 1 (P = 0.03 for pre‐ to postoperative 3 years, and P = 0.006 for pre‐ to final follow‐up). In additional evaluations comparing the subgroups of group 2 and group 1, group S showed relatively favourable results compared to group L in objective outcomes at final follow‐up.ConclusionPatients who underwent arthroscopic pull‐out repair for MMRT combined with MSP for accompanying high‐grade cartilage lesions showed suboptimal outcomes compared to those with no or low‐grade lesions at mid‐term follow‐up. High‐grade cartilage lesions ≤ 2.0 cm2 may be candidates for the surgical repair of MMRT if MSP are performed, but those with larger lesions may require alternative treatment strategies.Level of evidenceIII.
Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics
Authors: Deng Wenxiang , He Qinghu , Zhang Wenan 
Published: November 2023

AbstractCurcumin, a polyphenolic compound derived from the turmeric plant (Curcuma longa), has been extensively studied for its anti-inflammatory and anti-proliferative properties. The safety and efficacy of curcumin have been thoroughly validated. Nevertheless, the underlying mechanism for treating osteoarthritis remains ambiguous. This study aims to reveal the potential mechanism of curcumin in treating osteoarthritis by using metabolomics and transcriptomics. Firstly, we validated the effect of curcumin on inflammatory factors in human articular chondrocytes. Secondly, we explored the cellular metabolism mechanism of curcumin against osteoarthritis using cell metabolomics. Thirdly, we assessed the differences in gene expression of human articular chondrocytes through transcriptomics. Lastly, to evaluate the essential targets and elucidate the potential mechanism underlying the therapeutic effects of curcumin in osteoarthritis, we conducted a screening of the proteins within the shared pathway of metabolomics and transcriptomics. Our results demonstrated that curcumin significantly decreased the levels of inflammatory markers, such as IL-β, IL-6, and TNF-α, in human articular chondrocytes. Cell metabolomics identified 106 differential metabolites, including beta-aminopropionitrile, 3-amino-2-piperidone, pyrrole-2-carboxaldehyde, and various other components. The transcriptomic analysis yielded 1050 differential mRNAs. Enrichment analysis showed that the differential metabolites and mRNAs were significantly enriched in seven pathways, including glycine, serine, and threonine metabolism; pentose and glucuronate interconversions; glycerolipid metabolism; histidine metabolism; mucin-type o-glycan biosynthesis; inositol phosphate metabolism; and cysteine and methionine metabolism. A total of 23 key targets were identified to be involved in these pathways. We speculate that curcumin may alleviate osteoarthritis by targeting key proteins involved in glycine, serine, and threonine metabolism; inhibiting pyruvate production; and modulating glycolysis.
High contrast cartilaginous endplate imaging in spine using three dimensional dual-inversion recovery prepared ultrashort echo time (3D DIR-UTE) sequence
Authors: Athertya Jiyo S. , Lo James , Chen Xiaojun , Shin Soo Hyun , Malhi Bhavsimran Singh , Jerban Saeed , Ji Yang , Sedaghat Sam , Yoshioka Hiroshi , Du Jiang , Guma Monica , Chang Eric Y. , Ma Yajun 
Published: November 2023

Abstract
Purpose
To investigate the feasibility and application of a novel imaging technique, a three-dimensional dual adiabatic inversion recovery prepared ultrashort echo time (3D DIR-UTE) sequence, for high contrast assessment of cartilaginous endplate (CEP) imaging with head-to-head comparisons between other UTE imaging techniques.

Method
The DIR-UTE sequence employs two narrow-band adiabatic full passage (AFP) pulses to suppress signals from long T2 water (e.g., nucleus pulposus (NP)) and bone marrow fat (BMF) independently, followed by multispoke UTE acquisition to detect signals from the CEP with short T2 relaxation times. The DIR-UTE sequence, in addition to three other UTE sequences namely, an IR-prepared and fat-saturated UTE (IR-FS-UTE), a T1-weighted and fat-saturated UTE sequence (T1w-FS-UTE), and a fat-saturated UTE (FS-UTE) was used for MR imaging on a 3 T scanner to image six asymptomatic volunteers, six patients with low back pain, as well as a human cadaveric specimen. The contrast-to-noise ratio of the CEP relative to the adjacent structures—specifically the NP and BMF—was then compared from the acquired images across the different UTE sequences.

Results
For asymptomatic volunteers, the DIR-UTE sequence showed significantly higher contrast-to-noise ratio values between the CEP and BMF (CNRCEP-BMF) (19.9 ± 3.0) and between the CEP and NP (CNRCEP-NP) (23.1 ± 1.7) compared to IR-FS-UTE (CNRCEP-BMF: 17.3 ± 1.2 and CNRCEP-NP: 19.1 ± 1.8), T1w-FS-UTE (CNRCEP-BMF: 9.0 ± 2.7 and CNRCEP-NP: 10.4 ± 3.5), and FS-UTE (CNRCEP-BMF: 7.7 ± 2.2 and CNRCEP-NP: 5.8 ± 2.4) for asymptomatic volunteers (all P-values < 0.001). For the spine sample and patients with low back pain, the DIR-UTE technique detected abnormalities such as irregularities and focal defects in the CEP regions.

Conclusion
The 3D DIR-UTE sequence is able to provide high-contrast volumetric CEP imaging for human spines on a clinical 3 T scanner.
The dysfunctional immune response in renal cell carcinoma correlates with changes in the metabolic landscape of ccRCC during disease progression
Authors: Annels Nicola E. , Denyer M. , Nicol D. , Hazell S. , Silvanto A. , Crockett M. , Hussain M. , Moller-Levet Carla , Pandha Hardev 
Published: November 2023

AbstractRenal cell carcinoma is an immunogenic tumour with a prominent dysfunctional immune cell infiltrate, unable to control tumour growth. Although tyrosine kinase inhibitors and immunotherapy have improved the outlook for some patients, many individuals are non-responders or relapse despite treatment. The hostile metabolic environment in RCC affects the ability of T-cells to maintain their own metabolic programme constraining T-cell immunity in RCC. We investigated the phenotype, function and metabolic capability of RCC TILs correlating this with clinicopathological features of the tumour and metabolic environment at the different disease stages. Flow cytometric analysis of freshly isolated TILs showed the emergence of exhausted T-cells in advanced disease based on their PD-1high and CD39 expression and reduced production of inflammatory cytokines upon in vitro stimulation. Exhausted T-cells from advanced stage disease also displayed an overall phenotype of metabolic insufficiency, characterized by mitochondrial alterations and defects in glucose uptake. Nanostring nCounter cancer metabolism assay on RNA obtained from 30 ccRCC cases revealed significant over-expression of metabolic genes even at early stage disease (pT1-2), while at pT3-4 and the locally advanced thrombi stages, there was an overall decrease in differentially expressed metabolic genes. Notably, the gene PPARGC1A was the most significantly down-regulated gene from pT1-2 to pT3-4 RCC which correlated with loss of mitochondrial function in tumour-infiltrating T-cells evident at this tumour stage. Down-regulation of PPARGC1A into stage pT3-4 may be the ‘tipping-point’ in RCC disease progression, modulating immune activity in ccRCC and potentially reducing the efficacy of immunotherapies in RCC and poorer patient outcomes.