bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated analysis of randomized controlled trials evaluating bortezomib + lenalidomide + dexamethasone or bortezomib + thalidomide + dexamethasone induction in transplant-eligible newly diagnosed multiple myeloma
Authors: Rosiñol Laura , Hebraud Benjamin , Oriol Albert , Colin Anne-Laurène , Ríos Tamayo Rafael , Hulin Cyrille , Blanchard María Jesús , Caillot Denis , Sureda Anna , Hernández Miguel Teodoro , Arnulf Bertrand , Mateos Maria-Victoria , Macro Margaret , San-Miguel Jesús , Belhadj Karim , Lahuerta Juan José , Garelik M. Brigid , Bladé Joan , Moreau Philippe 
Published: November 2023

ObjectiveProviding the most efficacious frontline treatment for newly diagnosed multiple myeloma (NDMM) is critical for patient outcomes. No direct comparisons have been made between bortezomib + lenalidomide + dexamethasone (VRD) and bortezomib + thalidomide + dexamethasone (VTD) induction regimens in transplant-eligible NDMM.MethodsAn integrated analysis was performed using patient data from four trials meeting prespecified eligibility criteria: two using VRD (PETHEMA GEM2012 and IFM 2009) and two using VTD (PETHEMA GEM2005 and IFM 2013-04).ResultsThe primary endpoint was met, with VRD demonstrating a noninferior rate of at least very good partial response (≥ VGPR) after induction vs VTD. GEM comparison demonstrated improvement in the ≥ VGPR rate after induction for VRD vs VTD (66.3% vs 51.2%; P = .00281) that increased after transplant (74.4% vs 53.5%). Undetectable minimal residual disease rates post induction (46.7% vs 34.9%) and post transplant (62.4% vs 47.3%) support the benefit of VRD vs VTD. Treatment-emergent adverse events leading to study and/or treatment discontinuation were less frequent with VRD (3%, GEM2012; 6%, IFM 2009) vs VTD (11%, IFM 2013-04).ConclusionThese results supported the benefit of VRD over VTD for induction in transplant-eligible patients with NDMM. The trials included are registered with ClinicalTrials.gov (NCT01916252, NCT01191060, NCT00461747, and NCT01971658).
PIWIL1 gene polymorphism and pediatric acute lymphoblastic leukemia relapse susceptibility among Chinese children: a five-center case–control study
Authors: Ding Wenjiao , Wang Dao , Cai Mansi , Yan Yaping , Liu Shanshan , Liu Xiaodan , Luo Ailing , Deng Decheng , Liu Xiaoping , Jiang Hua 
Published: November 2023

ObjectivePIWIL1 polymorphisms’ role in pediatric acute lymphoblastic leukemia (ALL) relapse susceptibility remains undiscovered.MethodsA case–control designed and multiple logistic regression model was performed to evaluate the overall risk of pediatric ALL and five single-nucleotide polymorphisms (SNPs) of PIWIL1 gene (rs35997018 C&gt;T, rs1106042 A&gt;G, rs7957349 C&gt;G, rs10773771 C&gt;T, and rs10848087 A&gt;G) in 785 cases and 1,323 controls, which were genotyped by TaqMan assay. The odds ratio (OR) and its 95% confidence interval (CI) were used to estimate the relationship. Stratified analysis was used to investigate the correlation of rs1106042 and rs10773771 genotypes and pediatric ALL relapse susceptibility in terms of age, sex, number of white blood cells (WBC), immunophenotyping, gene fusion type, karyotype, primitive/naïve lymphocytes, and minimal residual disease (MRD) in bone marrow. Finally, the haplotype analysis was performed to appraise the relationship between inferred haplotypes of PIWIL1 and pediatric ALL risk.ResultsAmong the five analyzed SNPs, rs1106042 A&gt;G was related to increased ALL risk, and rs10773771 C&gt;T was related to decreased ALL risk. Compared to the GG genotype, the rs1106042 GA/AA had a deleterious effect on children of age &lt;120 months, who were female and male, had high or average number of WBC, pro-B ALL, pre-B ALL, T-ALL, low- and middle-risk ALL, E2A-PBX fusion gene, non-gene fusion, abnormal diploid, high hyperdiploid, hypodiploid, and normal diploid. Moreover, rs1106042 A&gt;G harmfully affected primitive/naïve lymphocytes and MRD on days 15–19, day 33, and week 12. On the contrary, rs10773771 TC/CC exhibited a protective effect on ALL children with the TEL-AML fusion gene. Haplotype analysis demonstrated that haplotypes CAGT, TACC, TACT, and TAGT were significantly associated with increased pediatric ALL relapse susceptibility.ConclusionPIWIL1 rs1106042 A&gt;G was related to increased ALL risk, and rs10773771 C&gt;T was linked to decreased ALL risk in eastern Chinese children. Rs1106042 GA/AA may predict poor prognosis.
Role of interleukins in the detection of neonatal sepsis: a network meta-analysis
Authors: Xing Wei , Wang Ying , Liu Jiao , Pei Jie , Yu Chengyong 
Published: November 2023

ObjectivesThe purpose of the network meta-analysis was to make a more comprehensive comparison of different interleukins in the detection of neonatal sepsis and to pose clues in the field of clinical practice.MethodsElectronic databases of PubMed, Web of Science and Embase were systematically searched. Eligible studies included diagnostic tests utilizing interleukins to detect neonatal sepsis. We calculated pooled sensitivity, specificity, positive Likelihood Ratio (PLR) and negative Likelihood Ratio (NLR), diagnostic odds ratio (DOR), and superiority index.ResultsFifteen studies including 1,369 neonates diagnosed of sepsis were included in this meta-analysis. For the detection of early-onset sepsis in neonates, the pooled sensitivity was 0.91 (95% CI: 0.81, 0.97; I2 = 0%, p = 0.946) and the pooled specificity was 0.98 (95% CI: 0.87, 0.97; I2 = 46.3%, p = 0.172) for IL-8. For the detection of late-onset sepsis in neonates. the sensitivity was 0.96 (95% CI: 0.85, 1.00; I2 = NA, p = NA) and the pooled specificity was 1.00 (95% CI: 0.92, 1.00; I2 = NA, p = NA) for IL-27. Results of ANOVA model revealed that the superiority index of IL-6, IL-8, IL-10, and IL-27 were 1.20 (0.14, 5.00), 5.14 (0.33, 7.00), 0.75 (0.14, 5.00), and 1.31 (0.14, 5.00) in the detection of early-onset neonatal sepsis. Superiority index of IL-8, IL-10, and IL-27 were 1.84 (0.20, 5.00), 1.04 (0.20, 5.00), and 2.21 (0.20, 5.00) in the detection of late-onset neonatal sepsis.ConclusionsFindings of this network meta-analysis suggest that interleukins including IL-6, IL-8, IL-10, and IL-27 may have favorable performance in the detection of neonatal sepsis. IL-8 was more accurate in the detection of early-onset sepsis in neonates. IL-27 was more accurate in the detection of late-onset neonatal sepsis.
En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma
Authors: Huang Haili , Tian Lijia , Sun Xinghuai , Chen Yuhong 
Published: November 2023

Purpose: To compare the morphological characteristics of Schlemm’s canal (SC) in patients with primary open-angle glaucoma (POAG) and healthy controls, using swept-source optical coherence tomography (SS-OCT) with en face reconstruction.Methods: In this Prospective comparative study, we included 100 eyes from 50 patients diagnosed with POAG and 50 healthy controls. Three-dimensional cube and line scans of the temporal and nasal quadrants of the anterior segment of the limbus were acquired using SS-OCT. SC was identified using en face and cross-sectional images. The diameter and area of SC in cross-sectional images and the visible percentage and area of SC in en face images were measured using ImageJ.Results: SC was observed in 84% of en face images and 81% of cross-sectional images in eyes with POAG but in 92% of en face images and 86% of cross-sectional images in control eyes. Significant differences between the POAG and normal control eyes were found in the en face area (0.35 ± 0.14 mm2 vs. 0.56 ± 0.22 mm2 in the temporal quadrant and 0.36 ± 0.14 mm2 vs. 0.58 ± 0.23 mm2 in the nasal quadrant; both p &lt; 0.001) and visible percentage of SC (85.71% vs. 94.91% and 87.10% vs. 95.52% in the temporal and nasal quadrant respectively, both p &lt; 0.001) in en face images as well as the cross-sectional area (2790.9 ± 942.2 μm2 vs. 4138.6 ± 2027.8 μm2 in the temporal quadrant and 2805.7 ± 947.2 μm2 vs. 4224.0 ± 2002.2 μm2 in the nasal quadrant, both p &lt; 0.001) and diameter of SC (123.1 ± 25.4 μm vs. 149.5 ± 34.7 μm in the temporal quadrant and 126.3 ± 28.9 μm vs. 155.3 ± 36.0 μm in the nasal quadrant, both p &lt; 0.001) in cross-section images. In addition, the mean intraocular pressure (IOP) significantly correlated with the en face area, visible percentage of SC, and cross-sectional area in the temporal and nasal quadrants.Conclusion: SS-OCT can obtain high-quality en face images of SC without post-acquisition processing. Eyes with POAG had a decreased en face SC area compared with normal eyes. A correlation between SC area, visible percentage of en face images, and IOP was also observed.
Improving power of genome-wide association studies via transforming ordinal phenotypes into continuous phenotypes
Authors: Yang Ming , Wen Yangjun , Zheng Jinchang , Zhang Jin , Zhao Tuanjie , Feng Jianying 
Published: November 2023

IntroductionOrdinal traits are important complex traits in crops, while genome-wide association study (GWAS) is a widely-used method in their gene mining. Presently, GWAS of continuous quantitative traits (C-GWAS) and single-locus association analysis method of ordinal traits are the main methods used for ordinal traits. However, the detection power of these two methods is low.MethodsTo address this issue, we proposed a new method, named MTOTC, in which hierarchical data of ordinal traits are transformed into continuous phenotypic data (CPData).ResultsThen, FASTmrMLM, one C-GWAS method, was used to conduct GWAS for CPData. The results from the simulation studies showed that, MTOTC+FASTmrMLM for ordinal traits was better than the classical methods when there were four and fewer hierarchical levels. In addition, when MTOTC was combined with FASTmrEMMA, mrMLM, ISIS EM-BLASSO, pLARmEB, and pKWmEB, relatively high power and low false positive rate in QTN detection were observed as well. Subsequently, MTOTC was applied to analyze the hierarchical data of soybean salt-alkali tolerance. It was revealed that more significant QTNs were detected when MTOTC was combined with any of the above six C-GWAs.DiscussionAccordingly, the new method increases the choices of the GWAS methods for ordinal traits and helps to mine the genes for ordinal traits in resource populations.
Outpatient care for adolescents’ and young adults’ mental health: promoting self- and others’ understanding through a metacognitive interpersonal therapy-informed psychological intervention
Authors: Marconi Elisa , Monti Laura , Fredda Giulia , Kotzalidis Georgios D. , Janiri Delfina , Zani Valentina , Vitaletti Debora , Simone Maria Velia , Piciollo Simone , Moriconi Federica , Di Pietro Emanuela , Popolo Raffaele , Dimaggio Giancarlo , Veredice Chiara , Sani Gabriele , Chieffo Daniela Pia Rosaria 
Published: November 2023

IntroductionPsychological distress may result in impairment and difficulty understanding oneself and others. Thus, addressing metacognitive issues in psychotherapy may improve psychopathology in adolescents and young adults (AYAs). We aimed to compare metacognitive interpersonal therapy (MIT)-informed psychotherapy with other treatment-as-usual (TAU) therapies.MethodsWe administered the Global Assessment of Functioning (GAF) scale, the Clinical Global Impressions–Severity (CGI-S) scale, and the Brief Psychiatric Rating Scale (BPRS) at baseline (BL) and at treatment termination (the endpoint was at 6 months and any last results obtained before that term were carried forward in analyzes). Patients received concomitant psychiatric and psychological treatment.ResultsSixty AYAs were involved in the study. There was a significant reduction in symptomatology after the intervention. Twelve patients (17%) dropped out; treatment adherence was 83%. In the MIT group, 2 patients dropped out (11%), and in the TAU group, 9 patients dropped out (19%). All scales showed a significant reduction in symptoms between baseline (BL) and the 6-month endpoint: GAF (χ2 = 6.61, p &lt; 0.001), BPRS (χ2 = 6.77, p &lt; 0.001), and CGI (χ2 = 7.20, p &lt; 0.001). There was a greater efficacy for the MIT group in terms of symptom reduction on the BPRS (t = 2.31; p &lt; 0.05).ConclusionThe study confirmed the efficacy of early and integrated care in adolescence and suggested greater symptom reduction for a psychotherapeutic intervention focused on stimulating mentalization skills. The study indicates the usefulness of this type of approach in the treatment of adolescent psychopathology. Due to the small sample size, the results need replication.
Analysis of hospital and payer costs of care: aggressive warming versus routine warming in abdominal major surgery
Authors: Song Shujia , Pei Lijian , Chen Hongda , Zhang Yuelun , Sun Chen , Yi Jie , Huang Yuguang 
Published: November 2023

BackgroundHypothermia is common and active warming is recommended in major surgery. The potential effect on hospitals and payer costs of aggressive warming to a core temperature target of 37°C is poorly understood.MethodsIn this sub-analysis of the PROTECT trial (clinicaltrials.gov, NCT03111875), we included patients who underwent radical procedures of colorectal cancer and were randomly assigned to aggressive warming or routine warming. Perioperative outcomes, operation room (OR) scheduling process, internal cost accounting data from the China Statistical yearbook (2022), and price lists of medical and health institutions in Beijing were examined. A discrete event simulation (DES) model was established to compare OR efficiency using aggressive warming or routine warming in 3 months. We report base-case net costs and sensitivity analyses of intraoperative aggressive warming compared with routine warming. Costs were calculated in 2022 using US dollars (USD).ResultsData from 309 patients were analyzed. The aggressive warming group comprised 161 patients and the routine warming group comprised 148 patients. Compared to routine warming, there were no differences in the incidence of postoperative complications and total hospitalization costs of patients with aggressive warming. The potential benefit of aggressive warming was in the reduced extubation time (7.96 ± 4.33 min vs. 10.33 ± 5.87 min, p &lt; 0.001), lower incidence of prolonged extubation (5.6% vs. 13.9%, p = 0.017), and decreased staff costs. In the DES model, there is no add-on or cancelation of operations performed within 3 months. The net hospital costs related to aggressive warming were higher than those related to routine warming in one operation (138.11 USD vs. 72.34 USD). Aggressive warming will have an economic benefit when the OR staff cost is higher than 2.37 USD/min/person, or the cost of disposable forced-air warming (FAW) is less than 12.88 USD/piece.ConclusionDespite improving OR efficiency, the economic benefits of aggressive warming are influenced by staff costs and the cost of FAW, which vary from different regions and countries.Clinical trial registrationclinicaltrials.gov, identifier (NCT03111875).
Development and validation of a device for monitoring laryngeal motion during swallowing
Authors: Aihara Keiko , Inamoto Yoko , Saitoh Eiichi , Shibata Seiko , Sato Yuriko , Harada Maki , Otaka Yohei 
Published: November 2023

Objectives: Hyolaryngeal movement during swallowing is essential to airway protection and bolus clearance. Although palpation is widely used to evaluate hyolaryngeal motion, insufficient accuracy has been reported. The Bando Stretchable Strain Sensor for Swallowing (B4S™) was developed to capture hyolaryngeal elevation and display it as waveforms. This study compared laryngeal movement time detected by the B4S™ with laryngeal movement time measured by videofluoroscopy (VF).Methods: Participants were 20 patients without swallowing difficulty (10 men, 10 women; age 30.6 ± 7.1 years). The B4S™ was attached to the anterior neck and two saliva swallows were measured on VF images to determine the relative and absolute reliability of laryngeal elevation time measured on VF and that measured by the B4S™.Results: The intra-class correlation coefficient of the VF and B4S™ times was very high [ICC (1.1) = 0.980]. A Bland–Altman plot showed a strong positive correlation with a 95% confidence interval of 0.00–3.01 for the mean VF time and mean B4S™ time, with a fixed error detected in the positive direction but with no proportional error detected. Thus, the VF and B4S™ time measurements showed high consistency.Conclusion: The strong relative and absolute reliability suggest that the B4S™ can accurately detect the duration of superior-inferior laryngeal motion during swallowing. Further study is needed to develop a method for measuring the distance of laryngeal elevation. It is also necessary to investigate the usefulness of this device for evaluation and treatment in clinical settings.
Single-center experience with the ClotTriever BOLD catheter for deep vein thrombosis percutaneous mechanical thrombectomy of the lower extremity
Authors: De Marco Garcia Lorena P. 
Published: November 2023

BackgroundThe ClotTriever System is a percutaneous mechanical thrombectomy system used to treat deep vein thrombosis (DVT). The BOLD catheter is a newer compatible component with a modified coring element for which reported outcomes are limited. This retrospective study aims to assess the preliminary procedural safety and success data for patients treated with the BOLD catheter.MethodsAll consecutive patients with symptomatic lower extremity DVT who underwent thrombectomy with the BOLD catheter between 23 November 2021 and 26 June 2022 at a single center were included. Baseline and procedural characteristics were reported. The primary outcome, intraprocedural safety, was assessed by a chart review of recorded intraprocedural adverse events (AEs) or device malfunction. The secondary outcome, procedural success, was defined as ≥75% reduction in the total occlusion across treated venous segments. This was assessed by an interventionalist review of pre- and postprocedural venograms. Additional outcomes included length of postprocedural hospital stay and assessment of AEs at discharge and a 30-day follow-up visit.ResultsEleven patient cases were reviewed. The median patient age was 65 years, the majority were women, and all were treated unilaterally. All procedures were completed in a single session without intraprocedural AEs or device malfunction. The median procedural blood loss was 50 ml. A review of pre- and postprocedural venograms showed that 35 venous segments were treated, including the femoral (n = 9), common femoral (n = 9), external iliac (n = 10), and common iliac (n = 7) veins. Procedural success was achieved in 10 patients (90.9%), and the median reduction rate in venous occlusion was 100%. The median length of postprocedural hospital stay was 1 day, and no AEs were noted at discharge (N = 11). One adverse event occurred among the eight patients who completed their follow-up visit. A patient with advanced-stage cancer and medication failure had a recurrent DVT 13 days postprocedure, which was not related to the device or procedure.ConclusionsNo safety concerns concerning the BOLD catheter were raised during the review of the cases included in this analysis, and the device was successful in reducing venous occlusion in patients with symptomatic proximal lower extremity DVT.
Pour un enseignement des littératures et des cultures d'origine des enfants immigrés
Authors: Langumier Maelise 
Published: November 2023

Les difficultés scolaires que rencontrent les enfants étrangers en France ne sont pas uniquement d’ordre linguistique, puisque la plupart d’entre eux maîtrisent bien le français oral. Il me semble que certains blocages scolaires viennent de l’ignorance, et du mépris où l’on tient les valeurs culturelles de leurs familles ; aussi m’est-il apparu important de faire prendre conscience aux enfants de travailleurs immigrés de la richesse de ces valeurs et de faire partager à leurs camarades français le plaisir de cette découverte.
Voici l’expérience que j’ai faite dans ce but durant le troisième trimestre de l’année 1975 dans deux classes de 5e du collège expérimental de Gagny (93) d’un enseignement des œuvres littéraires des pays d’origine.
Jeunes Vietnamiens anciennement et récemment installés en France
Authors: N’guyen-Thi-Chi Lan Myriam 
Published: November 2023

Vietnamienne en France, j’ai rencontré pour Migrants-Formation 5 jeunes de 16 à 20 ans dont les parents sont vietnamiens, et un Eurasien de 18 ans. Un garçon et une fille étaient nés au Vietnam, les autres en France. Deux étaient lycéens, leurs camarades, étudiants. L’entretien s’est déroulé en français, car si ces jeunes s’intéressent à la langue et la culture de leur famille, ils les connaissent mal.
Analisis Penilaian Persediaan Obat Dengan Menggunakan Metode Fifo Dan Average Di Klinik Idaman As’adiyah Sukorejo Banyuputih Situbondo
Authors: Shoimah Imroatus 
Published: November 2023

Penelitian ini bertujuan untuk menganalisis penilaian persediaan obat dengan menggunakan dua metode yakni metode FIFO dan Metode Average di klinik Idaman As’adiyah Sukorejo Banyuputih Situbondo. Berdasarkan hasil observasi, ada bayak jenis obat yang disiapkan oleh klinik. Akan tetapi hanya 2 (dua) jenis obat yang diputuskan menjadi sampel dalam penelitian ini dengan menggunakan teknik simple random sampling. Hasilnya menunjukkan bahwa penilaian persediaan dengan metode FIFO menunjukkan harga pokok penjualan yang lebih kecil dibandingkan dengan metode Average. Dengan demikian menunjukkan bahwa pengakuan laba kotor metode FIFO lebih besar daripada metode Average. Saran untuk Penelitian selanjutnya adalah memperluas sampel agar mendapatkan hasil yang lebih kuat.
ANALYSIS OF DATA ON PROCUREMENT AND USE OF INSULIN IN DIABETES MELLITUS PATIENTS AT THE GENERAL HOSPITAL Dr. FL TOBING SIBOLGA
Authors: Hasni Hasni Yaturramadhan Harahap , Sofyan Syarifuddin  , Debi Meilani  , Deliwarni Rajagukguk  , Fatimah Sari Simatupang  , Reni Aprinawaty Sirait  
Published: November 2023

Abstrak
Pengelolaan obat merupakan merupakan sebuah rangkaian pengendalian obat mulai dari proses seleksi, pengadaan, distribusi, hingga penggunaan. Pengelolaan obat berhubungan erat dengan anggaran dan belanja instalasi kesehatan seperti rumah sakit, puskesmas, dan apotek.Tujuan penelitian ini untuk kesesuaian pengadaan insulin di RSU. Dr. FL. Tobing Sibolga dengan kebutuhan pasien diabetes mellitus pada Tahun 2022. Metode penelitian ini meliputi penelitian deskriptif yaitu dengan melihat laporan pemakaian dan lembar permintaan insulin di RSU Dr. FL. Tobing Sibolga. Hasil penelitian menunjukkan Pengadaan Insulin pada Rumah Sakit FL. Tobing telah sesuai dengan kebutuhan/pemakaian insulin sepanjang Tahun 2022 dikarenakan Jumlah Pengadaan lebih besar dibandingkan dengan kebutuhan. Dan Hal ini tidak terdapat perbedaan signifikan jumlah insulin yg direncanakan dengan kebutuhan insulin sepanjang Tahun 2022.

Kata kunci: Pengelolaan, Penggunaan, Kesesuaian

Abstract
Drug management is a series of drug control starting from the process of selection, procurement, distribution, to use. Drug management is closely related to the budget and expenditure of health installations such as hospitals, health centers, and pharmacies. The aim of this study is to determine the suitability of insulin procurement in public hospitals. Dr. FL. Tobing Sibolga with the needs of diabetes mellitus patients in 2022. This research method includes descriptive research, namely by looking at usage reports and insulin request sheets at RSU Dr. FL. Tobing Sibolga. The results of the study showed that insulin was procured at the FL Hospital. Tobing is in accordance with the need/use of insulin throughout 2022 because the amount of procurement is greater than the need. And there is no significant difference in the planned amount of insulin and insulin needs throughout 2022.

Keywords: Management, Use, Appropriateness