bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Prophylactic Nifedipine on Renal Function in Patients Administered Contrast Media
Authors: Khoury Ziad , Schlicht John R. , Como Jennifer , Karschner Janet Kimberly , Shapiro Alvin R , Mook William J. , Weber Robert J. 
Published: October 2023

Study Objective. To determine if prophylaxis with nifedipine could decrease the frequency of contrast medium‐induced renal impairment.Design. Prospective, randomized clinical trial.Setting. A university‐affiliated hospital.Patients. Patients undergoing scheduled radiologic examinations involving infusion of contrast media.Interventions. Forty‐two patients were randomized to receive nifedipine 10 mg orally 1 hour before the imaging procedure, and 43 to receive no treatment.Measurements and Main Results. Baseline serum creatinine levels were compared with maximum levels 24 and 48 hours after administration of contrast medium. No statistically significant difference was seen in either the mean change or mean percentage change in serum creatinine between the control and nifedipine groups. The mean changes in serum creatinine were +7.4 μmol/L in the control group and +2.7 μmol/L in the nifedipine group (p=0.33); the mean percentage changes were +10.2% and +4.8%, respectively (p=0.54).Conclusion. Regardless of statistical analysis, it is unlikely that elevations in serum creatinine of this magnitude (< 0.1 mg/dl) are of clinical significance. We therefore conclude that prophylactic nifedipine is not clinically beneficial in preserving renal function in patients receiving contrast medium and that the agent should not be routinely administered for this purpose.
Comparative Evaluation of the Hemodynamic Effects of Oral Cimetidine, Ranitidine, and Famotidine as Determined by Echocardiography
Authors: Welage Lynda S. , Dunn‐Kucharski Valerie A. , Berardi Rosemary R. , Shea Michael J. , Dechert Ronald E. , Bleske Barry E. 
Published: October 2023

Study Objective. To evaluate the influence of cimetidine, ranitidine, famotidine, and placebo on cardiac performance as determined by echocardiography.Design. Randomized, four‐way crossover trial.Setting. Echocardiography laboratory at a university hospital.Participants. Twelve healthy volunteers.Interventions. Volunteers received oral treatment with placebo, cimetidine 800 mg, ranitidine 300 mg, or famotidine 40 mg once/day for 7 days.Measurements and Main Results. On the seventh day of each study phase, 2 hours after administration of the final dose, each subject underwent cardiac echocardiography and Doppler flow studies. No significant differences were detected in ejection fraction, peak flow velocity, or percentage fractional shortening among the treatment phases. A large degree of variability in ejection fraction was observed, with some subjects experiencing marked decreases.Conclusion. The histamine‐2 (H2)‐receptor antagonists had no effect on the hemodynamic variables as determined by echocardiography. The variability in the hemodynamic response may in part explain the conflicting results reported in the literature. It also raises the question as to whether certain individuals are more sensitive to the potential cardiac effects of H2‐receptor antagonists.
Tackling catheter‐associated urinary tract infections with next‐generation antimicrobial technologies
Authors: Duque‐Sanchez Lina , Qu Yue , Voelcker Nicolas H. , Thissen Helmut 
Published: October 2023

AbstractUrinary catheters and other medical devices associated with the urinary tract such as stents are major contributors to nosocomial urinary tract infections (UTIs) as they provide an access path for pathogens to enter the bladder. Considering that catheter‐associated urinary tract infections (CAUTIs) account for approximately 75% of UTIs and that UTIs represent the most common type of healthcare‐associated infections, novel anti‐infective device technologies are urgently required. The rapid rise of antimicrobial resistance in the context of CAUTIs further highlights the importance of such preventative strategies. In this review, the risk factors for pathogen colonization in the urinary tract are dissected, taking into account the nature and mechanistics of this unique environment. Moreover, the most promising next‐generation preventative strategies are critically assessed, focusing in particular on anti‐infective surface coatings. Finally, emerging approaches in this field and their likely clinical impact are examined.
Significant benthic fluxes of bioavailable dissolved amino acids to the ocean: Results from the East/Japan Sea
Authors: Park Hyekyung , Kim Guebuem , Kim Sung‐Han , Lee Jae Seong 
Published: October 2023

AbstractWe measured dissolved organic carbon (DOC) and total dissolved amino acid (TDAA) in seawater and sediment porewater of the Ulleung Basin in the East/Japan Sea. The DOC and TDAA concentrations were 1.1‐ and 1.4‐fold higher in the euphotic zone, and 11‐ and 43‐fold higher in sediment porewater, respectively, than those in the deep ocean. Consequently, in the deep ocean, TDAA and DOC input fluxes from porewater were 2‐ and 0.4‐fold of those from the euphotic zone, respectively. This larger contribution of benthic flux for TDAA and its shorter residence time in the benthic boundary layer (BBL) (1.3 ± 0.9 yr) seem to result in steep TDAA increases in the BBL, although DOC concentrations remained relatively uniform throughout the entire deep ocean. AA‐derived indices also show enhanced bioavailability of dissolved organic matter in the BBL. Benthic inputs seem to supply a significant amount of bioavailable TDAA to the deep ocean, fueling microbial activity.
Cooperative Passivation Exciton Quenching Triggers Surpassing 30% External Quantum Efficiency for a Deep‐Blue Organic Light‐Emitting Diode
Authors: Zhang Jiasen , Li Deli , Li Wei , Meng Yuanyuan , Ge Ziyi 
Published: October 2023

AbstractOvercoming exciton quenching and improving electroluminescence (EL) performances continue to pose persistent challenges in the development of efficient deep blue thermally activated delayed fluorescence (TADF) emitters. Herein, an asymmetric multi‐donors strategy is employed that provides the potential of establishing multiple radiative transition channels for fluorescence emission and reverse intersystem crossing (RISC), while allowing flexible modulation of packing modes in single‐crystal state and optimization of morphology in films by modifying the substitution site of the donor units. As a result, intermolecular π–π interactions are effectively alleviated and a very smooth surface with a reduced defect density is simultaneously achieved, which can significantly reduce the density of triplet excitons, accelerate the charge transfer rate, and enhance carrier injection efficiency. Consequently, a super‐high photoluminescence quantum yield (PLQY) of 99% and fast kRISC of 1.1 × 105 s−1 are concurrently achieved for the proof‐of‐concept emitter 3,4‐Cz‐SF‐SFAC. The corresponding deep‐blue organic light‐emitting diode (OLED) demonstrates an exceptional external quantum efficiency (EQE) of 31.1%, accompanied by an emission peak at 457 nm, one of the preeminent TADF materials within the deep blue region, ranking among the most efficient OLEDs with an EL spectra below 460 nm on record.
Organizational control for safety: A challenge in socioeconomic and natural environment
Authors: Ávila Filho Salvador 
Published: October 2023

AbstractThe concepts and applications of cases in human factors (HFs), risk, reliability, and crisis, include the analysis of complex systems and difficult to predict sociotechnical systems. Rules and barriers are designed or revised to achieve better organizational efficiency results. The investigation then valuates the concepts such as the basis, the tests such as confirmation, the algorithms such as methods and tools, and the validation that indicates the certainty of achieving good results. The human elements (HE) are part of the design and can either disable or enable the flow of hazard energy. The intention is that these HEs inside the safety culture and technology design act as safeguards. The HE avoids design deficiencies, social and physical. HE can reduce load over the resistance capacity. The culture, social phenomenon, company project, management and staff, group and worker, operational control, failure control, and accident and disaster are classes of HF that transform hazard energy and need efficient HE barriers. The internal and external regulation after these discussions needs to revise its principles to correct processes of standardization and organizational communication, which would change the procedures for team building and the criteria for the technology project. An improvement program includes investigation of lessons learned and behavior treatment.
Brassica‐derived isothiocyanates as anticancer therapeutic agents and their nanodelivery
Authors: Rizwan Danish , Masoodi Farooq Ahmad 
Published: October 2023

AbstractThe isothiocyanates (ITCs) derived from the precursor glucosinolate molecules present in Brassica vegetables are bioactive organo‐sulfur compounds with numerous pharmacologically important properties such as antioxidant, antiinflammatory, antimicrobial, and anticancer. Over the years, ITCs have been the focus of several research investigations associated with cancer treatment. Due to their potent chemo‐preventive action, ITCs have been considered to be promising therapeutics for cancer therapy in place of the already existing conventional anticancer drugs. However, their wide spread use at the clinical stage is greatly restricted due to several factors such as low solubility in an aqueous medium, low bioavailability, low stability, and hormetic effect. To overcome these hindrances, nanotechnology can be exploited to develop nano‐scale delivery systems that have the potential to enhance stability, and bioavailability and minimize the hermetic effect of ITCs.
Dynamically Cross‐Linked, Self‐Healable, and Stretchable All‐Hydrogel Supercapacitor with Extraordinary Energy Density and Real‐Time Pressure Sensing
Authors: Xu Muchun , Zhu Jiajun , Xie Jiyang , Mao Yongyun , Hu Wanbiao 
Published: October 2023

AbstractWearable electronics with flexible, integrated, and self‐powered multi‐functions are becoming increasingly attractive, but their basic energy storage units are challenged in simultaneously high energy density, self‐healing, and real‐time sensing capability. To achieve this, a fully flexible and omni‐healable all‐hydrogel, that is dynamically crosslinked PVA@PANI hydrogel, is rationally designed and constructed via aniline/DMSO‐emulsion‐templated in situ freezing‐polymerization strategy. The PVA@PANI sheet, not only possesses a honeycombed porous conductive mesh configuration with superior flexibility that provides numerous channels for unimpeded ions/electron transport and maximizes the utilization efficiency of pseudocapacitive PANI, but also can conform to complicated body surface, enabling effective detection and discrimination of body movements. As a consequence, the fabricated flexible PVA@PANI sheet electrode demonstrates an unprecedented specific capacitance (936.8 F g−1) and the assembled symmetric flexible all‐solid‐state supercapacitor delivers an extraordinary energy density of 40.98 Wh kg−1, outperforming the previously highest‐reported values of stretchable PVA@PANI hydrogel‐based supercapacitors. What is more, such a flexible supercapacitor electrode enables precisely monitoring the full‐range human activities in real‐time, and fulfilling a quick response and excellent self‐recovery. These outstanding flexible sensing and energy storage performances render this emerging PVA@PANI hydrogel highly promising for the next‐generation wearable self‐powered sensing electronics.
Powering the Future: Unleashing the Potential of MXene‐Based Dual‐Functional Photoactive Cathodes in Photo‐Rechargeable Zinc‐Ion Capacitor
Authors: Azadmanjiri Jalal , Regner Jakub , Děkanovský Lukáš , Wu Bing , Luxa Jan , Sofer Zdeněk 
Published: October 2023

AbstractDual‐functional photo‐rechargeable (photo‐R) energy storage devices, which acquire stored energy from solar energy harvesting, are being developed to battle the current energy crisis. In this study, these findings on the photo‐driven characteristics of MXene‐based photocathodes in photo‐R zinc‐ion capacitors (ZICs) are presented. Along with the pristine Ti3C2Tx MXene, tellurium/Ti3C2Tx (Te/Ti3C2Tx) hybrid nanostructure is synthesized via facile chemical vapor transport technique to examine them for photocathodes in ZICs. Interestingly, the evaluated self‐powered photodetector devices using MXene‐based samples revealed a pyro‐phototronic behavior introduced into the samples, with higher desirability observed in Te/Ti3C2Tx. The photo‐R ZICs results exhibited a capacitance enhancement of 50.86% for Te/Ti3C2Tx at two scan rates of 5 and 10 mV s−1 under illumination, compared to dark conditions. In contrast, a capacitance enhancement of 30.20% is obtained for the pristine Ti3C2Tx at only a 5 mV s−1 scan rate. Furthermore, both samples achieved photo‐charging voltage responses of ≈960 mV, and photoconversion efficiencies of 0.01% (for Te/ Ti3C2Tx) and 0.07% (for Ti3C2Tx). These characteristics in MXene‐based single photo‐R ZICs are significant and considerable with the distinguished integrated photo‐R supercapacitors with solar cells, or coupled energy‐harvesting and energy‐storing devices reported recently in the literature.
Catheter‐Assisted Bioinspired Adhesive Magnetic Soft Millirobot for Drug Delivery
Authors: Hu Xingyue , Zhou Yuting , Li Mengyue , Wu Junfeng , He Guannan , Jiao Niandong 
Published: October 2023

AbstractSoft millirobots have evolved into various therapeutic applications in the medical field, including for vascular dredging, cell transportation, and drug delivery, owing to adaptability to their surroundings. However, most soft millirobots cannot quickly enter, retrieve, and maintain operations in their original locations after removing the external actuation field. This study introduces a soft magnetic millirobot for targeted medicine delivery that can be transported into the body through a catheter and anchored to the tissues. The millirobot has a bilayer adhesive body with a mussel‐inspired hydrogel layer and an octopus‐inspired magnetic structural layer. It completes entry and retrieval with the assistance of a medical catheter based on the difference between the adhesion of the hydrogel layer in air and water. The millirobot can operate in multiple modes of motion under external magnetic fields and underwater tissue adhesion after self‐unfolding with the structural layer. The adaptability and recyclability of the millirobots are demonstrated using a stomach model. Combined with ultrasound (US) imaging, operational feasibility within organisms is shown in isolated small intestines. In addition, a highly efficient targeted drug delivery is confirmed using a fluorescence imaging system. Therefore, the proposed soft magnetic millirobots have significant potential for medical applications.
Sialic Acid‐Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy
Authors: Hu Jiahao , You Yuchan , Zhu Luwen , Zhang Jucong , Song Yanling , Lu Jingyi , Xu Xinyi , Wu Xiaochuan , Huang Xiajie , Xu Xiaoling , Du Yongzhong 
Published: October 2023

AbstractThe efficacy of immune checkpoint blockade (ICB) in promoting an immune response against tumors still encounters challenges such as low response rates and off‐target effects. Pyroptosis, an immunogenic cell death (ICD) mechanism, holds the potential to overcome the limitations of ICB by activating and recruiting immune cells. However, the expression of the pyroptosis‐related protein Gasdermin‐E(GSDME) in some tumors is limited due to mRNA methylation. To overcome this obstacle, sialic acid‐functionalized liposomes coloaded with decitabine, a demethylation drug, and triclabendazole, a pyroptosis‐inducing drug are developed. This nanosystem primarily accumulates at tumor sites via sialic acid and the Siglec receptor, elevating liposome accumulation in tumors up to 3.84‐fold at 24 h and leading to the upregulation of pyroptosis‐related proteins and caspase‐3/GSDME‐dependent pyroptosis. Consequently, it facilitates the infiltration of CD8+ T cells into the tumor microenvironment and enhances the efficacy of ICB therapy. The tumor inhibition rate of the treatment group is 89.1% at 21 days. This study highlights the potential of sialic acid‐functionalized pyroptosis nanotuners as a promising approach for improving the efficacy of ICB therapy in tumors with low GSDME expression through epigenetic alteration and ICD.
Fully Active Delivery of Nanodrugs In Vivo via Remote Optical Manipulation
Authors: Liu Xiaoshuai , Wu Shuai , Wu Huaying , Zhang Tiange , Qin Haifeng , Lin Yufeng , Li Baojun , Jiang Xiqun , Zheng Xianchuang 
Published: October 2023

AbstractThe active delivery of nanodrugs has been a bottleneck problem in nanomedicine. While modification of nanodrugs with targeting agents can enhance their retention at the lesion location, the transportation of nanodrugs in the circulation system is still a passive process. The navigation of nanodrugs with external forces such as magnetic field has been shown to be effective for active delivery, but the existing techniques are limited to specific materials like magnetic nanoparticles. In this study, an alternative actuation method is proposed based on optical manipulation for remote navigation of nanodrugs in vivo, which is compatible with most of the common drug carriers and exhibits significantly higher manipulation precision. By the programmable scanning of the laser beam, the motion trajectory and velocity of the nanodrugs can be precisely controlled in real time, making it possible for intelligent drug delivery, such as inverse‐flow transportation, selective entry into specific vascular branch, and dynamic circumvention across obstacles. In addition, the controlled mass delivery of nanodrugs can be realized through indirect actuation by the microflow field. The developed optical manipulation method provides a new solution for the active delivery of nanodrugs, with promising potential for the treatment of blood diseases such as leukemia and thrombosis.
Configuration of the dimolybdate in salt inclusion type of compounds, Cs2Mo2O7 ⋅ CsX (X=Cl, Br, and I)
Authors: Weber Anna Katharina , Denisova Ksenia , Lemmens Peter , Möller Angela 
Published: October 2023

AbstractCs2Mo2O7 ⋅ CsI is obtained as a member of the series Cs2Mo2O7 ⋅ CsX with X=Cl, Br, and I from the synthesis of Cs2MoO4 with MoO3 and CsX. At room temperature, the compounds crystallize in the space group P63/mmc with the dimolybdate, [Mo2O7]2−, in a linear and eclipsed conformation. Low temperature Raman spectroscopy and low temperature X‐ray diffraction were used to investigate the effect of the
hetero‐honeycomb lattice on the bridging angle of the dimolybdate. For X=Cl, a phase transition occurs below 150 K (P63/mmc → Cmcm). The phase transition relates to a lock‐in that involves bending of the (Mo−O−Mo) bridge. For the Pearson softer iodide compound, no phase transition is observed down to 4 K; thus, the linear configuration remains stable. Specific heat data and their evaluation in terms of phonon contributions are given.
Forward effects from action observation: the role of attentional focus
Authors: Ianì Francesco , Limata Teresa , Ras Ivan Nabil , Bucciarelli Monica 
Published: October 2023

AbstractAfter viewing an image representing an action on an object, we recognize the forward states of the seen action faster than the backward states. The present study exploits a variant of a new experimental paradigm to investigate cognitive mechanisms underlying this effect. Participants viewed a series of still photos of unfolding actions on objects, each followed by a photo depicting either one of three (instead of two of the original paradigm) different and temporally distant moments after the image or one moment before the image, along with photos of different actions. Experiment 1 revealed the classical forward effects in this new context: when the task was to judge whether the action in the second photo was the same as in the first photo, evaluations were faster for all forward photos than for backward photos. In Experiment 2, we examined the role of participants’ attention to the object alongside the role of attention to action kinematics in triggering these “forward effects” by manipulating participants’ attentional focus. As the results showed, evaluations were faster for all forward photos when the focus was on the action kinematics, but when the focus was on the object, evaluations were faster only for the last forward photo showing the final action state. These results seem to suggest that focusing on the object triggers a representation of the action goal and thus modulates the mental simulation underlying action anticipation.
Versuch über die Probedeutung
Authors: Storck Timo 
Published: October 2023

ZusammenfassungIn der Psychoanalyse haben Indikationsfragen eine besondere Bedeutung. Eine Möglichkeit, die Indikation für eine psychoanalytische Behandlung zu prüfen, liegt in der sogenannten Probedeutung. Diese bleibt jedoch konzeptuell unterbestimmt. In der vorliegenden Arbeit wird nach einer kurzen Erörterung der Funktion einer Deutung eine Skizze dazu vorgelegt, wie Probedeutungen konzeptuell verstanden und klinisch eingesetzt werden können: Probedeutungen fußen auf einer konkordanten Probeidentifizierung, sie stellen ein Sich-Vorwagen dar und haben eine weniger gesättigte Form als spätere Deutungen. Ihre Wirkung zeigt sich oft erst in der Folgestunde, sodass ihre Funktion auch darin gesehen werden kann, die Fähigkeit eines analytischen Nacharbeitens eines Patienten oder einer Patientin zu prüfen.
Image-based Navigation in Real-World Environments via Multiple Mid-level Representations: Fusion Models, Benchmark and Efficient Evaluation
Authors: Rosano Marco , Furnari Antonino , Gulino Luigi , Santoro Corrado , Farinella Giovanni Maria 
Published: October 2023

AbstractRobot visual navigation is a relevant research topic. Current deep navigation models conveniently learn the navigation policies in simulation, given the large amount of experience they need to collect. Unfortunately, the resulting models show a limited generalization ability when deployed in the real world. In this work we explore solutions to facilitate the development of visual navigation policies trained in simulation that can be successfully transferred in the real world. We first propose an efficient evaluation tool to reproduce realistic navigation episodes in simulation. We then investigate a variety of deep fusion architectures to combine a set of mid-level representations, with the aim of finding the best merge strategy that maximize the real world performances. Our experiments, performed both in simulation and on a robotic platform, show the effectiveness of the considered mid-level representations-based models and confirm the reliability of the evaluation tool. The 3D models of the environment and the code of the validation tool are publicly available at the following link: https://iplab.dmi.unict.it/EmbodiedVN/.
“Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects” as a form of hormesis: an interview with Professor Sataro Goto
Authors: Radak Zsolt 
Published: October 2023

AbstractProfessor Sataro Goto is one of the pioneers of biological aging research in Japan. He is renowned for his work on the role of protein errors and modifications, the accumulation of abnormal proteins due to reduced protein turnover, and the modulation of aging and lifespan by adult-onset dietary restriction and regular exercise. Professor Goto is a remarkably intelligent, visionary, empathetic, humble, and wise man, who kindly agreed to this interview that I (Zsolt Radak) made with him during one of my frequent visits to his labs, in February 2023.