bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnostic accuracy of lung ultrasound to determine PiCCO-derived extravascular lung water in invasively ventilated patients with COVID-19 ARDS
Authors: Atmowihardjo Leila N. , Schippers Job R. , Haaksma Mark E. , Smit Marry R. , Bogaard Harm J. , Heunks Leo , Juffermans Nicole P. , Schultz Marcus J. , Endeman Henrik , van Velzen Patricia , Tuinman Pieter R. , Aman Jurjan , Bos Lieuwe D. J. 
Published: October 2023

Abstract
Background
Lung ultrasound (LUS) can detect pulmonary edema and it is under consideration to be added to updated acute respiratory distress syndrome (ARDS) criteria. However, it remains uncertain whether different LUS scores can be used to quantify pulmonary edema in patient with ARDS.

Objectives
This study examined the diagnostic accuracy of four LUS scores with the extravascular lung water index (EVLWi) assessed by transpulmonary thermodilution in patients with moderate-to-severe COVID-19 ARDS.

Methods
In this predefined secondary analysis of a multicenter randomized-controlled trial (InventCOVID), patients were enrolled within 48 hours after intubation and underwent LUS and EVLWi measurement on the first and fourth day after enrolment. EVLWi and ∆EVLWi were used as reference standards. Two 12-region scores (global LUS and LUS–ARDS), an 8-region anterior–lateral score and a 4-region B-line score were used as index tests. Pearson correlation was performed and the area under the receiver operating characteristics curve (AUROCC) for severe pulmonary edema (EVLWi > 15 mL/kg) was calculated.

Results
26 out of 30 patients (87%) had complete LUS and EVLWi measurements at time point 1 and 24 out of 29 patients (83%) at time point 2. The global LUS (r = 0.54), LUS–ARDS (r = 0.58) and anterior–lateral score (r = 0.54) correlated significantly with EVLWi, while the B-line score did not (r = 0.32). ∆global LUS (r = 0.49) and ∆anterior–lateral LUS (r = 0.52) correlated significantly with ∆EVLWi. AUROCC for EVLWi > 15 ml/kg was 0.73 for the global LUS, 0.79 for the anterior–lateral and 0.85 for the LUS–ARDS score.

Conclusions
Overall, LUS demonstrated an acceptable diagnostic accuracy for detection of pulmonary edema in moderate–to–severe COVID-19 ARDS when compared with PICCO. For identifying patients at risk of severe pulmonary edema, an extended score considering pleural morphology may be of added value.
Trial registration: ClinicalTrials.gov identifier NCT04794088, registered on 11 March 2021. European Clinical Trials Database number 2020–005447-23.
Subchondral insufficiency fractures, subchondral insufficiency fractures with osteonecrosis, and other apparently spontaneous subchondral bone lesions of the knee—pathogenesis and diagnosis at imaging
Authors: Malghem Jacques , Lecouvet Frédéric , Vande Berg Bruno , Kirchgesner Thomas , Omoumi Patrick 
Published: October 2023

AbstractSubchondral insufficiency fractures (SIFs) and SIFs with osteonecrosis (SIF-ONs) of the knee (previously misnamed spontaneous osteonecrosis of the knee (SONK)) are bone lesions that appear without prior traumatic, tumoral, or inflammatory event.Both conditions are characterized in the early stages by epiphyseal bone marrow edema (BME)-like signal at MRI. However, while SIFs usually heal spontaneously, they can also evolve to osteonecrosis (i.e., SIF-ON), which may progress to an irreversible collapse of the articular surface. Careful analysis of other MRI signs may help differentiate the two conditions in the early phase. In SIFs, the BME edema-like signal extends to the area immediately adjacent to the subchondral plate, while in SIF-ONs, this subchondral area shows low signal intensity on fluid-sensitive MR images due to altered bone marrow. The thickness and length of subchondral areas with low fluid-sensitive signal intensity are important factors that determine the prognosis of SIF-ONs. If they are thicker than 4 mm or longer than 14 mm, the prognosis is poor. The differential diagnosis of SIFs and SIF-ONs include bone lesions associated with the “complex regional pain syndrome” (CRPS), epiphyseal osteonecrosis of systemic origin, and those related to cartilage pathology.Clinical relevance statement Imaging plays an essential role in diagnosing subchondral insufficiency fractures (SIFs) from subchondral insufficiency fractures with osteonecrosis (SIF-ONs) and collapse, as well as in distinguishing them from other spontaneous knee subchondral bone lesions presenting with bone marrow edema-like signal.Key points• Subchondral insufficiency fractures may affect the knee, especially in older adults.• Subchondral insufficiency fractures usually heal spontaneously.• Sometimes, subchondral osteonecrosis and collapse may complicate subchondral insufficiency fractures.• Bone marrow-like edema is an aspecific sign seen in all these lesions.• Degraded marrow in osteonecrosis complicating fractures is hypointense on fluid-sensitive sequences.
Graphical Abstract
Generalizations of Levinson type inequalities via new Green functions with applications to information theory
Authors: Rasheed Awais , Khan Khuram Ali , Pečarić Josip , Pečarić Đilda 
Published: October 2023

AbstractIn this paper, four new Green functions are used to generalize Levinson-type inequalities for the class of 3-convex functions. The f-divergence, Renyi entropy, Renyi divergence, Shannon entropy, and the Zipf–Mandelbrot law are also used to apply the main results to information theory.
Predictors of inoculant-based technology adoption by smallholder soybean farmers in northern Ghana: implications for soil fertility management
Authors: Anang Benjamin Tetteh , Dagunga Gilbert , Bosompem Martin 
Published: October 2023

AbstractInoculant-based technologies are environmentally friendly and economic ways to improve soil fertility status by incorporating atmospheric nitrogen into root nodules of leguminous crops to increase crop yield. The uptake of inoculant-based technologies by smallholder farmers in Ghana is not well documented despite measures by research institutions to introduce these technologies to farmers. This study therefore sought to investigate the farmer characteristics, farm-level, input and institutional-level determinants of inoculant-based technology adoption by small-scale soybean producers in Northern Ghana, relying on cross-sectional data and double-hurdle modelling. This study identified the main drivers of inoculant adoption as farmers’ age, sex, educational status, household size, agrochemicals adoption, soil fertility status, extension contact, farmer group membership and participation in off-farm work. Intensity of adoption, expressed as expenditure per hectare on inoculants was significantly influenced by household size, degree of specialization in soybean production, agrochemicals adoption, cost of ploughing, cattle ownership and participation in off-farm work. The results showed that the decision to adopt inoculant technology and the intensity of adoption are influenced by different sets of variables. Improving smallholders’ access to agricultural extension and promoting participation in farmer groups are expected to enhance inoculant technology adoption to promote grain legume production.
Beyond generalized anxiety: the association of anxiety sensitivity with disordered eating
Authors: Bazo Perez Maria , Hayes Timothy B. , Frazier Leslie D. 
Published: October 2023

Abstract
Background
Anxiety and eating disorders (EDs) are rising at alarming rates. These mental health disorders are often comorbid, yet the factors associated with their comorbidity are not well understood. The present study examined a theoretical model of the pathways and relative associations of anxiety sensitivity (AS) with different dimensions of ED risk, controlling for generalized anxiety.

Methods
Participants (N = 795) were undergraduate students with an average age of 21 (SD = 4.02), predominantly female (71%), and Hispanic (71.8%). Participants completed an online survey with established measures of AS (i.e., Anxiety Sensitivity Index-3; ASI-3), general anxiety (i.e., Beck Anxiety Inventory; BAI), and eating behaviors (i.e., Eating Attitudes Test-26; EAT-26).

Results
The results of our structural equation models indicated that AS subscales were significantly associated with dimensions of the EAT-26, even when controlling for generalized anxiety. Specifically, the ASI-3 factors reflecting cognitive and social concerns provided the most consistent significant associations with EDs. Whereas reporting higher cognitive concerns was associated with higher ED symptoms (e.g., reporting the urge to vomit after a meal), reporting higher social concerns was associated with fewer ED symptoms. These differential results may suggest risk and resilience pathways and potential protective or buffering effects of social concerns on ED risk.

Discussion
Findings advance understanding of the role of AS in the comorbidity of anxiety and EDs, demonstrating the strong association of AS with ED pathology. These findings provide cognitive indicators for transdiagnostic therapeutic intervention in order to reduce the risk of EDs.
Competency levels and influential factors of college students’ mobile learning readiness in Thailand
Authors: Diteeyont Watsatree , Heng-Yu Ku 
Published: October 2023

AbstractOne of the key successes of learning through mobile technology comes from the competencies of learners. This study aimed to investigate the overall competency levels of mobile learning readiness and four influential factors (connectivist learners, technology readiness, self-directed learning, and netiquette) that may impact college students’ mobile learning readiness in Thailand. The surveys were given to 583 Thai college students who came from various fields such as Social Science, Agriculture, Engineering and Computer Science, and Science. Descriptive statistical procedures were used to generate overall mobile learning readiness and the confirmatory factor analysis was used to determine whether the competencies of connectivist learners, technology readiness, self-directed learning, and netiquette influence the mobile learning readiness of college students in Thailand. The results showed that overall mobile learning readiness among Thai college students was at a high level in which learners’ competency in technology readiness was the most influential factor related to their mobile learning readiness, followed by the competencies of self-directed learning, netiquette, and connectivist learners. The results of this study could provide useful guidance for instructors in designing effective instruction, activities, and learning materials that encourage learners to be successful in the mobile learning environment. The future study may explore other related factors such as learners’ cultural backgrounds, educational systems, or government supports that may influence mobile learning readiness among learners in higher education in different countries.
Beneficial role of healthy eating Index-2015 score & physical activity on COVID-19 outcomes
Authors: Hegazy Mona A , Fouad Marwa M , Abd elshafy Samah Ahmed , Abdelfatah Dalia , Lithy Rania M , Abdelghani Ahmed , Ashoush Omar Ahmed 
Published: October 2023

Abstract
Background
Nutritional status and physical activity are essential to maintain a strong immune system. No definite pharmacological strategies for Coronavirus disease 2019 treatment are presently available, so natural enhancement of the immune system is in need. Our goal was to assess the correlation of healthy diet and physical activity on COVID-19 disease outcome.

Methods
This cohort study was conducted on 68 adult patients who contracted mild (38) or moderate [30] cases of COVID-19, recruited via a convenience sampling technique from the outpatient clinic, Kasr Al-Aini Faculty of Medicine, Cairo University Hospital. Patients’ Healthy Eating Index (HEI) and degree of physical activity as measured by the Global Physical Activity Questionnaire were evaluated and linked with several inflammatory markers.

Results
Most of patients with mild COVID-19 patients (92.1%) were physically active, compared to only 50% of moderate COVID-19. The total Metabolic Equivalent Task-min/week was positively correlated with the lymphocyte percentage. The median total HEI score was significantly higher in the patients with mild COVID-19 than with moderate COVID. Significant positive correlations observed among the lymphocyte count and total HEI-2015. There was approximately a 64% reduction in the probability of acquiring moderate COVID-19 illness for each unit rise in The HEI.

Conclusion
Healthier nutrition and Physical activity correlated with reduced COVID-19 disease severity.

Trial registration
The study was registered on clinical trial.gov maintained by the US National Library of Medicine (CinicalTrials.gov identifier = NCT04447144; https://clinicaltrials.gov/) (25/06/2020).
Real-world practice patterns of eplerenone use for central serous chorioretinopathy
Authors: Venkatesh Ramesh , Prabhu Vishma , Joshi Aishwarya , Mangla Rubble , Singh Rishi , Wu Lihteh , Lanzetta Paolo , Kuppermann Baruch , Bandello Francesco , Cohen Francine Behar , Chhablani Jay 
Published: October 2023

Abstract
Purpose
To report eplerenone use by retina specialists worldwide for central serous chorioretinopathy (CSCR).

Methods
A self-reporting questionnaire was distributed to retina specialists worldwide to gather clinicians’ perspectives on CSCR cases treated, eplerenone dosage and duration, reasons to use it, and side effects.

Results
The survey included 241 retina specialists (122 Indian and 119 international) with an average experience of 15.69 ± 9.59 years. Oral eplerenone was used to treat CSCR by 149 (62%) participants. Only 6% (n = 9) had easy access to verteporfin dye and photodynamic therapy. 30 (20%) of the 149 respondents changed their treatment with eplerenone after VICI trial results. Eplerenone was prescribed mostly for chronic CSCR (n = 86, 58%), regardless of involvement laterality. 62% (n = 92) had fewer than 25% CSCR cases treated with eplerenone. 85 (57%) respondents used eplerenone only when other treatments failed, while 36 (24%) used it as first-line treatment. 73 (49%) respondents, prescribed eplerenone at a 50 mg daily dose and 137 (92%) retina specialists used eplerenone for 0–3 months. The drug’s efficacy dissatisfied 21 (14%) study participants. 124 (83%) study participants did not encounter any ocular or systemic side effects with eplerenone use. Eplerenone related kidney and electrolyte issues were noted by 11 (7%) study participants.

Conclusion
The treatment of CSCR varies around the world and is primarily influenced by the photodynamic therapy availability and the findings of VICI trial. Despite the limited benefit of eplerenone reported by the VICI trial, it is still used as evidenced by real-world experience.

Trial Registration Number
Not applicable.
The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation
Authors: Li Ping , Li Jingxia , Huang Haoyuan , Chen Xiongnong , Lin Yue , He Ganlin , Xu Duorong 
Published: October 2023

Abstract
Background
A virus infection may lead the body to produce more immune cells of particular types or stimulate the production of new ones, both of which may have anti-leukemic effects. There has been no research on whether immune cells stimulated by varicella-zoster virus (VZV) infection have anti-leukemic effects. The objective of this investigation is to assess the impact of VZV infection on patients' long-term survival following allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods
This retrospective study investigated the association between varicella-zoster virus (VZV) reactivation and outcomes in 219 individuals who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the Sun Yat-sen University’s First Affiliated Hospital. According to being diagnosed with VZV infection or not, these patients were grouped into two groups. The comparison of cumulative incidence of relapse, non-recurrent mortality, and overall survival (OS) was conducted between the two groups.

Results
Analyzing multivariate data, VZV reactivation was linked to lower relapse incidence in the group containing all individuals (hazard ratio [HR] = 0.27; 95% confidence interval [CI], 0.12–0.64), patients suffering from acute myeloid leukaemia (HR = 0.10; 95% CI, 0.01–0.83), and patients suffering from acute lymphoblastic leukaemia (HR = 0.25; 95% CI, 0.08–0.77). Moreover, VZV reactivation was linked with decreased non-relapse mortality in all individuals (HR = 0.20; 95% CI, 0.05–0.79), but no statistical significance was found for any disease subgroup. Further, VZV reactivation was an independent predictor for improved OS in the group containing all individuals (HR = 0.10; 95% CI, 0.03–0.29), patients suffering from acute myeloid leukaemia (HR = 0.09; 95% CI, 0.01–0.66), and patients suffering from acute lymphoblastic leukaemia (HR = 0.16; 95% CI, 0.04–0.68).

Conclusion
This is the first study to show that VZV reactivation following allo-HSCT is an independent predictor for lower relapse rates and improved OS, providing novel therapeutic approaches to improve patients’ long-term survival following allo-HSCT.
Antimicrobial peptide Mastoparan X has good activity against Escherichia coli in vitro and alleviates its pathogenicity in mice
Authors: Zhao Xueqin , Luo Weiyu , Wang Lei , Zhu Chunling , Xue Xianghong , Xia Xiaojing , Wu Xilong , Bai Yueyu , Hu Jianhe 
Published: October 2023

Abstract
Background
Escherichia coli is a facultative anaerobic bacterium that normally resides in the gastrointestinal tract of humans and animals but can cause diarrhea and enteritis. MPX is an antimicrobial peptide extracted from wasp venom and has potent bactericidal effects against many bacteria. This study aimed to investigate the mechanism of MPX’s bactericidal activity against E. coli in vitro, its effect on IPEC-J2 cell apoptosis and barrier function, and its therapeutic efficacy against E. coli infection in mice.

Methods
The effects of MPX on E. coli were investigated in vitro, at the cellular level, and in vivo.

Results
The study found that the MIC of MPX against E. coli was 31.25 µg/mL, and scanning electron microscopy showed that MPX caused the bacteria to become smaller in size with leaked contents. Additionally, NPN, PI, and DiSC3(5) results showed that MPX positively correlated with the fluorescence intensity. MPX significantly inhibited E. coli biofilm formation. Furthermore, MPX effectively reduced IPEC-J2 cell apoptosis, regulated ZO-1, Occludin, and Claudin-1 expression through the Rac1 pathway, and alleviated the pathological damage in the intestine, as shown by H&E staining results. qRT-PCR results indicated that MPX increased TFF3 mRNA expression in the jejunum and colon.

Conclusions
This study is the first to explore the mechanism of MPX's bactericidal activity against E. coli in vitro, providing a foundation for developing new drugs to treat bacterial infections.

Graphical Abstract
Comparative study between open lumbopelvic fixation and percutaneous iliosacral fixation for management of sacral fractures
Authors: Elhabashy Abdelrahman Magdy , Fayed Ahmed Abdelaziz , Sorour Islam 
Published: October 2023

AbstractBackgroundThe main aim of surgical intervention for unstable sacral fractures is to obtain a solid construct across the lumbopelvic junction to allow for early mobilization. Both iliosacral screw fixation (ISF) and lumbopelvic fixation (LPF) are widely used surgical techniques used for treatment of unstable sacral fractures. Nevertheless, it is unclear whether one technique provides more favorable postoperative outcomes than the other.ObjectiveTo compare the three-year outcome of ISF versus LPF in patients with unstable sacral fractures as regard effectiveness and safety of both techniques.MethodsThe study included 54 patients with sacral fractures who underwent sacral fusion using either ISF or LPF at a single institution. Patients were followed up for at least 3 years. Operative and postoperative data were collected and statistically calculated.ResultsThirty patients were included in the ISF group and 24 patients in the LPF group. The operative time was notably higher in the LPF group (mean 107 min compared to 33 min in the ISF group;p = 0.002). Blood loss was also higher in the LPF group (mean 320 ml compared to 96 ml in the ISF;p = 0.004). Assessment of pelvic fusion was done via Majeed and Matta scores (pelvic fusion outcome scores). The ISF and LPF groups had a comparable Majeed score at the end of the third year of follow-up (excellent rate = 53.3% vs. 58.3%, respectively;p = 0.93). Likewise, ISF and LPF groups had comparable Matta score at the end of the third year of follow-up (excellent rate = 66.7% vs. 70.8%, respectively;p = 0.27). The most commonly reported postoperative complications in the ISF group were screw malposition in 2 cases out of 30 cases (6.6%) and non-union in 2 cases out of 30 cases (6.6%). On the other hand, the most commonly reported postoperative complications in the LPF group were implant prominence in 3 cases out of 24 cases (12.5%) and infection in 2 cases out of 24 cases (8.3%).ConclusionLPF and ISF have comparable safety and efficacy in patients with sacral fractures. ISF is an excellent and safe method of fixation, especially in old age to avoid open surgery-related complications. LPF is preferred in young active patients to benefit from rapid weight bearing after surgery and in cases with ambiguous sacral anatomy as sacral dysmorphism.
Protocol for a systematic review of living labs in agricultural-related systems
Authors: Yousefi Maryam , Ewert Frank 
Published: October 2023

Abstract
Background
Living labs are innovative platforms that bring together stakeholders (academic and non-academic actors from diverse disciplines), to collaboratively co-create, develop and test new technologies, products, services in real-life environments. As living labs become increasingly popular in addressing sustainability challenges in agriculture, it is essential to understand the potential of living labs to support innovation in the agricultural context. However, the existing knowledge is dispersed, and uncertainties remained regarding their approaches, methods, and outcomes. To address this gap, this study outlines a systematic review protocol of the existing literature on living labs in agricultural-related contexts. This will be done through questions focusing on the contributions of living labs to agricultural sustainability and innovation, their effectiveness, and strategies for development and implementation. Additionally, it will identify areas that require further research and development to advance our understanding of these initiatives.

Method
This study will be conducted according to the RepOrting Standards for Systematic Evidence Syntheses (ROSES) review protocol. We will search databases, including Scopus, Web of Science (core collection) and Google Scholar, which will be limited to titles, abstracts, and keywords in English to eliminate irrelevant literature. The quality of the method used for each selected study will be evaluated using the Critical Appraisal Skills Program, Qualitative Research Checklist. Coding and data extraction will include for example bibliographic information, types of agricultural practices tested, dominant framework (e.g. open innovation, user innovation, and participatory design), the contribution of living lab in agriculture, stakeholder roles, etc. We will use thematic analysis to synthesise our findings. We will compare descriptive and narrative sub-groups to take into account differences in living lab concepts in relation to the context, outcomes, and limitations.

Conclusions
The results of this review will provide a foundation for informing user-centred innovations in agriculture using living lab methodology. Researchers and practitioners working in areas such as co-design which incorporate user involvement, collaboration, and knowledge exchange, may also benefit from these findings.