bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of the state of cervical cancer: updates from prevention to recurrent disease
Authors: Crafton Sarah M. , Venkat Puja S. , Salani Ritu 
Published: October 2023

Purpose of review
To summarize the recent updates in cervical cancer from prevention and early detection to the management of early stage and recurrent disease as well as future areas of exploration.

Recent findings
The importance of the human papilloma virus vaccine and screening continue to make an impact in reducing the global burden of cervical cancer. In early-stage, low risk disease, new studies have demonstrated the role of less radical surgery with similar disease related outcomes. Efforts to improve outcomes in locally advanced cervical cancer have been reported. The incorporation of adjuvant chemotherapy, novel agents and checkpoint inhibitors, with the latter impacting disease free survival. In advanced/recurrent disease, the role of immunotherapy continues to make an impact and, in addition to recurrent disease, has now moved to the frontline for patients with programmed cell death ligand 1 expression. Tisotumab vedotin, an antibody drug conjugate, and other novel agents continue to be studied in this setting.

Summary
In this review, we discuss prevention measures and the outcomes of recent trials in all stages of cervical cancer. As therapies continue to evolve, ongoing trials and new areas of exploration will continue to identify opportunities to improve survival in cervical cancer.
The effects of therapeutic touch and music on sleep quality, menopausal symptoms, and quality of life in menopausal women
Authors: Keskin Töre Fatma , Yağmur Yurdagül 
Published: October 2023

Abstract

Objectives
This study aimed to examine the effects of therapeutic touch (TT) and music on sleep quality, menopausal symptoms, and quality of life in menopausal women.

Methods
This study was carried out in an experimental model with a pretest, a posttest, and a control group. The study was completed with a total of 108 menopausal women in the TT, music, and control groups. Data were collected using a Participant Information Form, the Pittsburgh Sleep Quality Index, the Menopause Rating Scale, and the Menopause-Specific Quality of Life Scale. TT was applied in the TT group once a week for 4 weeks, and the music group was asked to listen to music for 30 minutes before bedtime every day for 4 weeks. Posttest data were collected in all groups 4 weeks after the pretest. The χ2, analysis of covariance, post hoc tests, and partial η
2 methods were used to analyze the collected data.

Results
When the effect of the pretest scores was adjusted, compared with the control group, there were statistically significant differences in the posttest scores of the participants in both the TT and music groups in the Pittsburgh Sleep Quality Index dimensions of subjective sleep quality (P < 0.001), sleep latency (P ≤ 0.001), and sleep disturbances (P < 0.05). When the effect of the pretest scores was adjusted, compared with the control group, there were statistically significant differences in the posttest scores of the participants in both the TT and music groups in the Menopause Rating Scale and Menopause-Specific Quality of Life Scale (P < 0.001).

Conclusions
It was concluded that TT and music increased sleep quality (subjective sleep quality, sleep latency, and sleep disturbances) and quality of life and reduced menopausal symptoms.
Left atrial appendage closure: the journey today and tomorrow
Authors: Lu Marvin Louis Roy , De Lurgio David Bowers 
Published: October 2023

Purpose of review
This review aims to discuss the rationale behind the development of percutaneous LAAC devices as a treatment option for atrial fibrillation patients ineligible for long-term anticoagulation. The evolution of LAAC, from early experiences and challenges to risk mitigation and improved devices and techniques, will be examined. Furthermore, the review will explore our current understanding of the potential and limitations of LAAC in stroke prevention.

Recent findings
Multiple trials confirm LAAC device safety and efficacy for stroke prevention, but peri-device leak and thrombus remain concerns postimplantation. Even small leaks pose increased stroke risk. While guidelines suggest short-term anticoagulation postimplant; real-world data show equivalent efficacy with dual antiplatelet regimen.

Summary
LAAC device design has evolved and now serve as a viable option for stroke prevention in high-risk atrial fibrillation patients, offering protection in the absence of anticoagulation.
A Ten-Year Retrospective Cohort Study of Real-World Effectiveness of Sofosbuvir-Based Regimens for Hepatitis C in a Single Center in China
Authors: Yang Qiao , Xu Fangping , Shen Yi , Pi Borui , Lv Fangfang 
Published: October 2023

Abstract
This study aimed to review the trends of hepatitis C virus (HCV) treatment over the past decade and to analyze the effectiveness of sofosbuvir (SOF)-based direct-acting antiviral regimens in the heterogeneous population of patients with chronic hepatitis C (CHC) in clinical practice. This retrospective cohort study included CHC patients attending the Sir Run Run Shaw Hospital between January 1, 2012 and December 31, 2022. All of the 194 patients treated with SOF-based regimens completed 12 weeks of treatment and were followed up for at least 12 weeks after completion of the therapy. Sustained virologic response (SVR) 12 weeks after the end of treatment was the primary endpoint. A total of 194 patients treated with SOF-based regimens were included, among which 121, 56, 10 and 7 patients received SOF + velpatasvir±ribavirin, SOF + daclatasvir, SOF + ledipasvir or SOF + ribavirin, respectively. With 36.1%, HCV genotype 1 predominated in CHC patients treated with SOF-based regimens, followed by genotype 2a with 17.5% and genotype 3 with 14.9%. Comorbidities among patients included hypertension (4.1%), diabetes (2.1%), depression (1.0%) and neoplastic disease (2.6%). All patients treated with SOF-based regimens achieved SVR. There was no association between SVR and factors such as HCV genotype, sex, age, presence of cirrhosis or previous treatment history. There were no reports of any serious adverse events in the study. This single-center retrospective study represented the latest 10-year treatment trends for HCV in real-world clinical practice and provided useful information on the excellent efficacy of SOF-based direct-acting antiviral regimens for treatment of CHC patients in Eastern China.
Prevalence of Depression in Elderly People Living With HIV: A Systematic Review and Meta-analysis
Authors: Ahmed Gasmelseed Y. , Saha Chandni , Almusalami Eman M. , Rabaan Ali A. , Alhumaid Saad , Ali Abdelraheem A. , Basheer AbdAllah A. , Babikir Yousra , Aljofan Ziyad Fahad , Al Mutair Abbas 
Published: October 2023

Abstract
We conducted a systematic review and meta-analysis to determine the prevalence of depression among elderly people living with HIV. We searched electronic databases and included 12 observational studies that reported on depression among people who were 50 years of age or older and had HIV. The studies were mostly hospital-based and from Western and African countries. They included a total of 5868 older people with HIV, of whom 1667 had depression. Pooled prevalence of depression was 28% with heterogeneity of 95.2%. Prevalence ranged from 14.5% in the Netherlands to 42.4% in South Africa. Although there was asymmetry in the funnel plot, the Egger’s test showed no significant publication bias. Our meta-analysis found a high burden of depression among older people with HIV. Comprehensive health services addressing psychosocial needs and interventions to prevent and treat depression are needed, especially in community settings. Healthcare providers and policymakers should address the prevalence of depression in such communities.
Erysipeloid and Erysipelothrix rhusiopathiae Bacteremia Secondary to a Crab Stab Wound: A Case Report and Literature Review
Authors: Deng Chaowen , Li Xin , Liu Defu , Sun Linlin , Ye Haiyan , Xing Fanfan 
Published: October 2023

Abstract

Erysipelothrix rhusiopathiae is a facultative anaerobic, nonmotile, nonspore-forming, gram-positive bacillus. It is a zoonotic pathogen that rarely infects humans but causes swine erysipelas. The disease caused by E. rhusiopathiae can manifest in the following three main forms: erysipeloid, diffuse cutaneous infections, and bacteremia with or without endocarditis. In this article, we present the case study of a healthy Chinese man who developed erysipeloid and an E. rhusiopathiae bloodstream infection after being stabbed by a crab. Additionally, we conducted a thorough review of the available literature on E. rhusiopathiae bacteremia within the past two decades and provided a summary of the key findings. Early diagnosis and proper treatment are crucial in mitigating recurrence risk and avoiding sepsis. Understanding the risk factors for death from E. rhusiopathiae bacteremia is essential, and appropriate personal protective equipment should be used to prevent occupational exposure to this bacterium.
The Importance of Multidisciplinary Trauma-Informed Training in Addressing Campus-Based Sexual Violence
Authors: Selwyn Candice N. , Koon-Magnin Sarah , Dixon Victoria , Rudd Alison 
Published: October 2023

ABSTRACT
This study investigates the impact of a professional development training series among a multidisciplinary team (MDT) during establishment of a trauma-informed sexual assault response and prevention program at a midsized university in the southeastern United States. MDT members included forensic nurses, advocates, counselors, law enforcement officers, and relevant faculty and staff. After completion of a baseline survey assessing attitudes toward trauma-informed care and perceptions of the team climate within the MDT, team members engaged in a trauma-informed care (TIC) professional development training series consisting of (a) 4-hour-long didactic lectures with incorporated group discussion and (2) one 2-hour in-situ simulation-based training exercise. MDT members subsequently completed 3-month and long-term follow-up surveys to assess the immediate and enduring impacts of the training series.
The TIC training series significantly increased MDT members' perceptions of participative safety, task orientation, and support for innovation within the group at the 3-month assessment. No long-term differences were found, likely because of a small sample size and low statistical power.
Intensive TIC MDT professional development at the beginning of a campus-wide sexual assault prevention and response initiative enhances psychological safety within the group, evidenced by increased perceptions of participative safety and support for innovation, and builds team cohesiveness around a shared set of tasks. Within the present MDT, the professional development training series also appeared to facilitate adoption of a shared set of values for accomplishing the team's goal of preventing and responding to sexual assault on campus. Recommendations for MDTs with similar goals are discussed.
Rationale for the Development of a Novel Clinical Grading Scale for Postoperative Facial Nerve Function: Results of a Multidisciplinary International Working Group
Authors: Carlson Matthew L. , Lohse Christine M. , Agazzi Siviero , Babu Seilesh C. , Barker Frederick G. , Barnett Samuel , Bi Wenya Linda , Biggs Nigel , Boahene Kofi D. , Breen Joseph T. , Brown Kevin D. , Cayé-Thomasen Per , Cosetti Maura K. , Deep Nicholas L. , Dey Jacob K. , Dornhoffer James R. , Forner David , Gurgel Richard K. , Hansen Marlan R. , Hunter Jacob B. , Kalamarides Michel , Kim Irene A. , King Andrew T. , Kircher Matthew L. , Lassaletta Luis , Link Michael J. , Lloyd Simon K.W. , Lund-Johansen Morten , Marinelli John P. , Matthies Cordula , Mehta Vikas , Moore Eric J. , Nassiri Ashley M. , Neff Brian A. , Nelson Rick F. , Olson Jeffrey J. , Patel Neil S. , Celda Maria Peris , Plitt Aaron R. , Price Daniel L. , Thomas Roland J. , Sweeney Alex D. , Tasche Kendall K. , Tatagiba Marcos , Tveiten Øystein , Van Gompel Jamie J. , Vrabec Jeffrey T. , Wanna George B. , Weisskopf Peter A. 
Published: October 2023

Objective
The objective of the current study was to present the results of an international working group survey identifying perceived limitations of existing facial nerve grading scales to inform the development of a novel grading scale for assessing early postoperative facial paralysis that incorporates regional scoring and is anchored in recovery prognosis and risk of associated complications.

Study Design
Survey.

Setting
A working group of 48 multidisciplinary clinicians with expertise in skull base, cerebellopontine angle, temporal bone, or parotid gland surgery.

Results
House-Brackmann grade is the most widely used system to assess facial nerve function among working group members (81%), although more than half (54%) agreed that the system they currently use does not adequately estimate the risk of associated complications, such as corneal injury, and confidence in interrater and intrarater reliability is generally low. Simplicity was ranked as the most important attribute of a novel postoperative facial nerve grading system to increase the likelihood of adoption, followed by reliability and accuracy. There was widespread consensus (91%) that the eye is the most critical facial region to focus on in the early postoperative setting.

Conclusions
Members were invited to submit proposed grading systems in alignment with the objectives of the working group for subsequent validation. From these data, we plan to develop a simple, clinically anchored, and reproducible staging system with regional scoring for assessing early postoperative facial nerve function after surgery of the skull base, cerebellopontine angle, temporal bone, or parotid gland.
Comparing Speech Recognition Outcomes Between Cochlear Implants and Auditory Brainstem Implants in Patients With NF2-Related Schwannomatosis
Authors: Dornhoffer James R. , Plitt Aaron R. , Lohse Christine M. , Driscoll Colin L.W. , Neff Brian A. , Saoji Aniket A. , Van Gompel Jamie J. , Link Michael J. , Carlson Matthew L. 
Published: October 2023

Objective
To compare cochlear implant (CI) and auditory brainstem implant (ABI) performance in patients with NF2-related schwannomatosis (NF2)

Study Design
Historical cohort.

Setting
Tertiary academic center.

Patients
A total of 58 devices among 48 patients were studied, including 27 ABIs implanted from 1997 to 2022 and 31 CIs implanted from 2003 to 2022. Three patients had bilateral ABIs, three had bilateral CIs, three had an ABI on one side and a CI on the other, one had a CI that was later replaced with an ipsilateral ABI, and one had an ABI and CI concurrently on the same side.

Interventions
CI or ABI ipsilateral to vestibular schwannoma.

Main Outcome Measures
Open-set speech perception, consonant-nucleus-consonant word scores, and AzBio sentence in quiet scores.

Results
Among all patients, 27 (47%) achieved open-set speech perception, with 35 (61%) daily users at a median of 24 months (interquartile range [IQR], 12–87 mo) after implantation. Comparing outcomes, CIs significantly outperformed ABIs; 24 (77%) CIs achieved open-set speech perception compared with 3 (12%) ABIs, with median consonant-nucleus-consonant and AzBio scores of 31% (IQR, 0–52%) and 57% (IQR, 5–83%), respectively, for CIs, compared with 0% (IQR, 0–0%) and 0% (IQR, 0–0%), respectively, for ABIs. Patients with ABIs were younger at diagnosis and at implantation, had larger tumors, and were more likely to have postoperative facial paresis.

Conclusion
Many patients with NF2-associated vestibular schwannoma achieved auditory benefit with either a CI or an ABI; however, outcomes were significantly better in those patients who were able to receive a CI. When disease and anatomy permit, hearing rehabilitation with a CI should be considered over an ABI in these patients. Tumor management strategies that increase the ability to successfully use CIs should be strongly considered given the high risk of losing bilateral functional acoustic hearing in this population.
Cognition and nutrition: the role of dietary protein and amino acids in cognitive health
Authors: Nagao Kenji 
Published: October 2023

Purpose of review
This review underscores recent advancements in the role of protein and amino acid nutrition on cognitive health. Given the escalating prevalence of neurodegenerative disorders, particularly Alzheimer's disease, it is essential to understand nonpharmaceutical interventions that could potentially counteract their development and progression.

Recent findings
Emerging research indicates that moderate protein intake may offer protective benefits against dementia. Studies also emphasize the importance of considering not just the quantity, but also the quality and source of dietary protein. The role of essential amino acids in nutrition is gaining attention in the field of cognitive health. Moreover, plasma-free amino acid concentrations, particularly branched-chain amino acids, are being explored as potential biomarkers for cognitive health and Alzheimer's disease. Mechanistic studies suggest that proteins and amino acids help maintain neuronal integrity, reduce inflammation, and support muscle retention, all essential factors for cognitive health.

Summary
Recent findings emphasize the complex relationship between protein, amino acids, and cognitive health, highlighting the potential of dietary interventions in warding off neurodegenerative diseases. Given the observational nature of these findings, further interventional and longitudinal studies are needed to ascertain causality and elucidate the mechanisms involved.
The colitis may be microscopic, but the diarrhea is not: update on the treatment of microscopic colitis and immune checkpoint inhibitor colitis
Authors: Enwerem Ngozi Y. , Yen Eugene F. 
Published: October 2023

Purpose of review
Microscopic colitis is an inflammatory disease of the colon that presents as watery diarrhea with minimal to normal endoscopic changes on colonoscopy. It encompasses two common subtypes, lymphocytic colitis and collagenous colitis, which are both treated similarly.
Immune checkpoint inhibitor colitis is among the most common immune-related adverse events. Endoscopic and histological findings range from normal colonic mucosa to inflammatory bowel like changes. This review article provides update in treatment and management of microscopic colitis and immune checkpoint inhibitor colitis (ICPi colitis).

Recent findings
Recent studies on microscopic colitis have focused on the successful use of immunomodulators such as biologics for treatment of budesonide refractory microscopic colitis cases. Microscopic colitis does not confer an added risk for colorectal cancer.
With the increasing usage of immunotherapy agents, immune checkpoint inhibitor colitis is becoming more common. ICPi colitis can be successfully managed with steroids, with treatment stepped up to biologics for moderate to severe cases or for mild cases that do not respond to steroids. Immunotherapy agents can be carefully re-introduced in mild cases, after treatment of ICPi colitis.

Summary
Biologics can be used to treat budesonide refractory microscopic colitis. ICPi colitis can be managed with steroids and biologics in moderate to severe cases.
Sociocultural Framework for Psychiatric Case Formulation
Authors: Weiss Mitchell G. , Deshmukh Ankita , Sarmukaddam Sanjeev B. , Paralikar Vasudeo P. 
Published: October 2023

Abstract
A Cultural Formulation Interview (CFI) field trial in India, widely reported racist violence in the United States, and casteist and religious communal conflicts in India highlighted inattention to structural issues affecting mental health problems in the Outline for Cultural Formulation (OCF) and the CFI in the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition). Consequently, we revised the OCF as a sociocultural formulation (SCF) to better consider structures of society and culture. We studied and compared clinicians' ratings of SCF case formulations from a constructed assessment instrument (SCF Interview [SCFI]) and the CFI. Socio-cultural formulations from SCFI interviews were rated higher for details of societal structural impact, and overall interrater agreement was better. CFI interviews were rated higher for clinical rapport. Revision of the CFI should enhance consideration of structural issues and incorporate them in SCFs that better integrate assessment process and case formulation content. The need to acknowledge structural sources of mental health problems is clear, and our study indicates how a sociocultural framework may be used for that.
Addressing Workplace Violence With Evidence
Authors: Bauersfeld Sara , Majers Joan Sevy 
Published: October 2023

AIM
The purpose of this article is to describe how regional community assessment survey data specific to healthcare workers' (HCWs') attitudes and actions related to workplace violence (WPV) from 1 participating urban tertiary hospital was compared with current evidence to identify evidence-based interventions to promote a safer work environment. The regional survey assessed real-time data regarding the state of WPV and its impact on HCWs, and to drive proposed interventions to prevent and reduce WPV in the healthcare community.

BACKGROUND
Incidents of WPV in healthcare continue to increase, resulting in calls for action from staff, leadership, and regulatory organizations.

METHODS
Data were collected from the HCWs who completed the survey. Experiences with WPV were analyzed. Qualitative data were evaluated for themes. A review of external evidence was conducted to identify best practices in preparing proposed next steps for the organization.

RESULTS
Healthcare worker attitudes and practices related to WPV were described as unreported and not addressed. Violence was more readily perceived as a part of the job. External evidence indicated that education and training alone seemed to have minimal effect on preventing WPV. Evidence from best practices and staff feedback were recommended to be incorporated into plans for the organization.