bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe lung disease in children with cystic fibrosis missed in newborn screening
Authors: Baldwin Kathrine , Barker Erin McElroy , Carayannopoulos Mary , Farrell Philip M. , Zanni Robert , Scanlin Thomas F. 
Published: October 2023

AbstractBackgroundCystic fibrosis (CF) is now routinely diagnosed through newborn screening (NBS), but the tests employed in the USA have been evolving for two decades as missed cases become recognized and lab methods improve in association with more knowledge about CF genetics. New Jersey was among the first states to implement CF NBS in 2001 when it introduced the original two‐tiered method that combined measurements of immunoreactive trypsinogen (IRT) with detection of the principal pathogenic variant (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.ObjectiveWith continuation of the IRT/DNA (F508del) algorithm for two decades and identification of screening false negative children, we decided to examine the condition of some missed cases with special attention to their respiratory status.MethodsTo strengthen the arguments for quality improvement in New Jersey's CF NBS program, we reviewed and evaluated false negative cases to determine the potential extent of preventable patient suffering as a consequence of delayed diagnoses.ResultsFive children with CF who had false negative screening results were studied in detail. In each case there was a different cause of the negative screening results. They all had clinically significant/severe lung disease, ranging from chronic cough with CF pathogens on respiratory culture at a young age to respiratory failure.ConclusionThis case series highlights the consequences of false negative screening results, which served as the impetus to upgrade New Jersey's CF NBS algorithm. Implemented changes include lowering the IRT cutoff to 70 ng/mL and expanding to a 139 variant CFTR panel. In 2023, a floating IRT cutoff is anticipated to be implemented.
Seasonal differences in tropical cyclone—induced sea surface cooling in the western North Pacific
Authors: Singh Vineet Kumar , Kim Hye‐Ji , Moon Il‐Ju 
Published: October 2023

AbstractTropical cyclone (TC)‐induced sea surface temperature (SST) cooling plays an important role in controlling the intensity of TCs in ocean basins and can modulate the local weather. This study examined the seasonal differences in TC‐induced SST cooling, especially between summer (June–August) and autumn (September–November), in the western North Pacific for the period 1992–2021. The analysis shows that the average maximum TC‐induced SST cooling along the TC track in autumn is 0.18°C less than in summer, although the mean TC intensity in autumn is 14 knots higher than in summer. This is because in autumn, the average mixed‐layer depth is 10–13 m deeper than in summer, and the TC track shifts equatorward, preventing the entrainment of cooler subsurface water to the surface, thereby causing less SST cooling in autumn at the same TC intensity. Given the negative feedback of TC‐induced SST cooling on TC intensity, these results are crucial to understand the seasonal differences in the intensity of TC in this basin.
Demonstrating software reliability using possibly correlated tests: Insights from a conservative Bayesian approach
Authors: Salako Kizito , Zhao Xingyu 
Published: October 2023

AbstractThis paper presents Bayesian techniques for conservative claims about software reliability, particularly when evidence suggests the software's executions are not statistically independent. We formalise informal notions of “doubting” that the executions are independent, and incorporate such doubts into reliability assessments. We develop techniques that reveal the extent to which independence assumptions can undermine conservatism in assessments, and identify conditions under which this impact is not significant. These techniques – novel extensions ofconservative Bayesian inference(CBI) approaches – give conservative confidence bounds on the software's failure probability per execution. With illustrations in two application areas – nuclear power‐plant safety and autonomous vehicle (AV) safety – our analyses reveals: (1) the confidence an assessor should possess before subjecting a system to operational testing. Otherwise, such testing is futile – favourable operational testing evidence will eventually decrease one's confidence in the system being sufficiently reliable; (2) the independence assumption supports conservative claims sometimes; (3) in some scenarios, observing a system operate without failure gives less confidence in the system than if some failureshadbeen observed; (4) building confidence in a system is very sensitive to failures – each additional failure means significantly more operational testing is required, in order to support a reliability claim.
Remote state estimator design under the round‐Robin protocol
Authors: Wu Chengwei , Chai Qingjie , Chen Yucheng , Yin Liyuan , Zhu Hongming 
Published: October 2023

SummaryThis paper focuses on the remote estimation problem for cyber‐physical systems under the round‐Robin protocol. A round‐Robin protocol‐based Kalman filter is deployed to estimate the real system states on the remote side. When sensor measurements are transmitted by communication networks, the round‐Robin protocol with the zero‐input‐holder strategy is adopted to determine which sensor measurements are transmitted, reducing the communication burden and risk of being attacked. Both the protocol‐based open‐loop and closed‐loop estimation scenarios are considered. The delay resulting from adopting the protocol with the zero‐input‐holder strategy is handled effectively. Corresponding filtering algorithms are proposed, and the estimation error covariance is proved to be converged. Finally, in addition to the effectiveness of the proposed round‐Robin protocol‐based filtering algorithms, simulation results are given to demonstrate that the performance of the proposed filtering algorithms can match that of the classical Kalman filter.
Achieving Ideal and Environmentally Stable n‐Type Charge Transport in Polymer Field‐Effect Transistors
Authors: Yao Ze‐Fan , Wu Hao‐Tian , Zhuang Fang‐Dong , Zhang Peng‐Fei , Li Qi‐Yi , Wang Jie‐Yu , Pei Jian 
Published: October 2023

AbstractRealizing ideal charge transport in field‐effect transistors (FETs) of conjugated polymers is crucial for evaluating device performance, such as carrier mobility and practical applications of conjugated polymers. However, the current FETs using conjugated polymers as the active layers generally show certain non‐ideal transport characteristics and poor stability. Here, ideal charge transport of n‐type polymer FETs is achieved on flexible polyimide substrates by using an organic‐inorganic hybrid double‐layer dielectric. Deposited conjugated polymer films show highly ordered structures and low disorder, which are supported by grazing‐incidence wide‐angle X‐ray scattering, near‐edge X‐ray absorption fine structure, and molecular dynamics simulations. Furthermore, the organic‐inorganic hybrid double‐layer dielectric provides low interfacial defects, leading to excellent charge transport in FETs with high electron mobility (1.49 ± 0.46 cm2 V−1 s−1) and ideal reliability factors (102 ± 7%). Fabricated polymer FETs show a self‐encapsulation effect, resulting in high stability of the FET charge transport. The polymer FETs still work with high mobility above 1 cm2 V−1 s−1 after storage in air for more than 300 days. Compared with state‐of‐the‐art conjugated polymer FETs, this work simultaneously achieves ideal charge transport and environmental stability in n‐type polymer FETs, facilitating rapid device optimization of high‐performance polymer electronics.
Cost‐Effective Nanophotonic Metasurfaces with Spatially Gradient Structures for Ultrasensitive Imaging‐Based Refractometric Sensing
Authors: Li Guohua , Wen Baohua , Yang Ji , Wu Mingxi , Zhou Bin , Ye Xiangyi , Tang Hao , Zhou Jianhua , Cai Jingxuan 
Published: October 2023

AbstractNanophotonic metasurfaces are widely utilized in various domains, such as biomedical, healthcare, and environmental monitoring, benefiting from their unique advantages of label‐free, noninvasive, and real‐time response. However, nanophotonic metasurfaces usually rely on sophisticated instruments, and expensive and time‐consuming fabrication processes, which severely restricts their practical applications. Herein, a spatially gradient metasurface is integrated with an imaging‐based sensing scheme, waiving the requirement of spectrometers and achieving an ultrahigh imaging‐based sensitivity of 3321 pixels/refractive index unit superior to that characterized using conventional compact spectrometers. The metasurface is fabricated by nanoimprint lithography using a reusable cyclic olefin copolymer template featuring millions of unique nanostructures. Under the illumination of monochromatic light, the transmittance of different nanostructures on the metasurface differs, resulting in grayscale images with varied intensity distributions. Analyzing the intensity change of the metasurface's recorded image can obtain the covering medium's refractive index. Furthermore, through theory and experimentation, the high reliability of the proposed reusable and flexible template has been verified for nanophotonic metasurface fabrication which further reduces the fabrication cost of core sensing elements. Finally, with proper optimization of the metasurface structure and imaging system, this setup is expected to be applied to many emerging areas of point‐of‐care, real‐time, and on‐site biosensing.
Report of the Registration Committee
Authors: Loizeau Pierre‐André , Brinda John , Head Martin J. , Ulloa Carmen Ulloa 
Published: October 2023

AbstractThe Registration Committee was established at the Nomenclature Section of the XIX International Botanical Congress (IBC) in Shenzhen, China in 2017. It followed the previous Special Committee on Registration of Algal and Plant Names (including fossils). A clear majority of Registration Committee members support having named taxa associated with a unique universal digital identifier in order to secure and facilitate the exchange of information by electronic means. However, discussions within the Committee showed that mandatory referencing of a unique universal digital identifier was not a solution. The Committee recommends that authors provide nomenclatural repositories with a reference to an actual and current publication for indexing purposes, or to register voluntarily.
Mapping QTL for vernalization requirement identified adaptive divergence of the candidate gene Flowering Locus C in polyploid Camelina sativa
Authors: Chaudhary Raju , Higgins Erin E. , Eynck Christina , Sharpe Andrew G. , Parkin Isobel A. P. 
Published: October 2023

AbstractVernalization requirement is an integral component of flowering in winter‐type plants. The availability of winter ecotypes among Camelina species facilitated the mapping of quantitative trait loci (QTL) for vernalization requirement in Camelina sativa. An inter and intraspecific crossing scheme between related Camelina species, where one spring and two different sources of winter‐type habit were used, resulted in the development of two segregating populations. Linkage maps generated with sequence‐based markers identified three QTLs associated with vernalization requirement in C. sativa; two from the interspecific (chromosomes 13 and 20) and one from the intraspecific cross (chromosome 8). Notably, the three loci were mapped to different homologous regions of the hexaploid C. sativa genome. All three QTLs were found in proximity to Flowering Locus C (FLC), variants of which have been reported to affect the vernalization requirement in plants. Temporal transcriptome analysis for winter‐type Camelina alyssum demonstrated reduction in expression of FLC on chromosomes 13 and 20 during cold treatment, which would trigger flowering, since FLC would be expected to suppress floral initiation. FLC on chromosome 8 also showed reduced expression in the C. sativa ssp. pilosa winter parent upon cold treatment, but was expressed at very high levels across all time points in the spring‐type C. sativa. The chromosome 8 copy carried a deletion in the spring‐type line, which could impact its functionality. Contrary to previous reports, all three FLC loci can contribute to controlling the vernalization response in C. sativa and provide opportunities for manipulating this requirement in the crop.
Perceived enablers and barriers impacting sustainability of small‐and‐medium sized enterprises: A quantitative analysis in four European countries
Authors: Moursellas Andreas , Malesios Chrisovalantis , Skouloudis Antonios , Evangelinos Konstantinos , Dey Prasanta Kumar 
Published: October 2023

AbstractSmall and medium‐sized enterprises (SMEs) often lag behind major corporations in implementing sustainability management practices, limiting their capacity to mitigate negative social and environmental impacts. A notable challenge is the lower percentage of SMEs with sustainability objectives. This research aims to examine the links among sustainability practices and performance of European SMEs. In addition, the causal relationships between enablers/barriers for sustainability practices are also examined. To achieve these objectives, a quantitative research approach was employed. Data were collected from 420 SMEs located in the United Kingdom, France, Spain, and Greece using a structured questionnaire. Statistical modeling and inference were used to analyze the responses, separately for each of the four countries. The study revealed several significant findings. Strong relationships were identified between enablers/barriers and sustainability practices. The study found consistent links between supply chain sustainability practices and SME performance across all participating countries. The research highlighted similarities and differences in findings across various economies and geographical regions. The study's findings have important implications; For policymakers insights from this research can inform policy decisions aimed at promoting sustainability among SMEs, thus contributing to broader social and environmental goals. For SME owners and managers the findings offer guidance for improving sustainable performance through operational, planning, and strategic decisions. Policymakers should consider initiatives that encourage SMEs to adopt sustainability practices. SME owners and managers should prioritize supply chain sustainability and work on overcoming barriers identified in this study. Further research should explore specific strategies for enhancing sustainability practices in different regions and economies.
Sexuelle Gewalt als Denkunmöglichkeit: „weil das einfach (.) so n unding ist, und so=was einfach so gar nicht geht und sein darf“
Authors: Wittfeld Meike 
Published: October 2023

ZusammenfassungFür die Orientierung der Fachkräfte wurde rekonstruiert, dass sie sich in keinster Weise in sexuelle Gewalttaten verstrickt sehen, gleichzeitig werden sie von den Medien und teilweise von der eigenen Organisation unter Generalverdacht gestellt. Daraus ergibt sich eine Inkongruez. Die nun folgenden Ergebnisse schließen genau hier an. In den Blick genommen wird hierfür, wie in den Gruppendiskussionen gesprochen wird. Dabei finden sich abermals mehr Homologien als Unterschiede zwischen den Teams. Da die Homologien eine ungewöhnlich breite gemeinsame Orientierung über alle Teams hinweg beschreiben, sind sie besonders relevant. Vor diesem Hintergrund ist dieses Kapitel auch strukturiert. Es geht zunächst (11.1) um die Sprache, die Worte und Formulierungen, die im Diskursverlauf verwendet werden. Die leitende Frage dabei lautet: Wie wird über sexuelle Gewalt gesprochen? Im zweiten Teil des Kapitels (11.2) wird deutlich werden, dass die Distanzierung der Fachkräfte von sexueller Gewalt damit einhergeht, dass sie sich sexuelle Gewalt in ihrem konkreten Arbeitsalltag nicht oder nur sehr schwer vorstellen können.
Tatverdacht und Gewalttat als Anlass der Thematisierung von sexueller Gewalt in Institutionen: „das traurige ende war das der mitarbeiter sich erhangen hat“
Authors: Wittfeld Meike 
Published: October 2023

ZusammenfassungIm Folgenden wird nun auf Tatverdächtigungen gegen pädagogische Fachkräfte (9.1) und Grenzverletzungen durch pädagogische Fachkräfte (9.2) eingegangen, um diese konkreten Vorfälle als Anlass für die Thematisierung von sexueller Gewalt näher zu beleuchten.
Strategies to remove hydrological effects in continuous gravity time series
Authors: Mouyen Maxime 
Published: October 2023

AbstractMulti-annual gravity time series offer a unique, noninvasive way to monitor mass redistributions within the Earth. However, for non-hydrological purposes, gravity time series must be corrected from hydrological effects to properly quantify mass redistribution involved in other geodynamic processes, such as volcanic activities or sedimentation processes. Such a hydrological correction remains challenging. The objective of this work is to investigate various ways to remove hydrological effects from a 11-years long gravity time series acquired by a superconducting gravimeter (SG) located at the Onsala Space Observatory (Sweden). For that we use hydrological loading corrections distributed by the EOST loading service, and local in situ groundwater level measurements. The most efficient approaches correct up to 89% of the seasonal component of the hydrological signal in the gravity series. On the other hand, for that specific site, we observe local water redistributions at shorter time scales, hours to few days, have a negligible influence on the gravity time series.
Making paper labels smart for augmented wine recognition
Authors: Angeli Alessia , Stacchio Lorenzo , Donatiello Lorenzo , Giacchè Alessandro , Marfia Gustavo 
Published: October 2023

AbstractAn invisible layer of knowledge is progressively growing with the emergence of situated visualizations and reality-based information retrieval systems. In essence, digital content will overlap with real-world entities, eventually providing insights into the surrounding environment and useful information for the user. The implementation of such a vision may appear close, but many subtle details separate us from its fulfillment. This kind of implementation, as the overlap between rendered virtual annotations and the camera’s real-world view, requires different computer vision paradigms for object recognition and tracking which often require high computing power and large-scale datasets of images. Nevertheless, these resources are not always available, and in some specific domains, the lack of an appropriate reference dataset could be disruptive for a considered task. In this particular scenario, we here consider the problem of wine recognition to support an augmented reading of their labels. In fact, images of wine bottle labels may not be available as wineries periodically change their designs, product information regulations may vary, and specific bottles may be rare, making the label recognition process hard or even impossible. In this work, we present augmented wine recognition, an augmented reality system that exploits optical character recognition paradigms to interpret and exploit the text within a wine label, without requiring any reference image. Our experiments show that such a framework can overcome the limitations posed by image retrieval-based systems while exhibiting a comparable performance.
Does the Interest Parity Puzzle Hold for Central and Eastern European Economies?
Authors: Dąbrowski Marek A. , Janus Jakub 
Published: October 2023

AbstractThis paper examines the uncovered interest parity puzzle in Central and Eastern European countries. Apart from investigating baseline UIP regressions, we check for structural breaks in this relationship, scrutinize deviations from the UIP, and employ different estimation methods and models augmented with various risk measures. Moreover, we offer several extensions to the common UIP testing that account for foreign-exchange interventions, the implied volatility of exchange rates, and the limited availability of data on direct measures of market expectations. The study shows that the choice of the reference currency matters for the outcome of the interest parity tests in the CEE economies. In particular, we demonstrate that inconsistencies between the results of the UIP tests vis-à-vis the euro and the US dollar that appear in CEE economies may be accounted for by the movements of the euro-dollar risk premium. This regularity has not been documented in previous studies. Additionally, we show that (a) the FX interventions in Czechia distorted the UIP, (b) the directly measured exchange rate expectations (granular survey data) in Poland do not seem to be informed by the UIP relationship, (c) the limited resilience of CEE economies to rare disasters may plausibly explain deviations from the UIP.
Towards oxidoreductase-based processes for the removal of antibiotics from wastewater
Authors: de Boer Sabrina Rose , Schäffer Andreas , Moreira Maria Teresa 
Published: October 2023

AbstractThe occurrence of antibiotics in surface waters is an alarming issue that can be addressed by advanced wastewater treatment technologies. Among them, enzymatic treatment is an emerging technology claimed to provide prospective benefits in terms of efficiency, controllability, and safety. This review illustrates the current state of research focused on enzyme-based approaches for pollutant abatement, specifically on the most critical classes of antibiotics (e.g. tetracyclines, sulfonamides, fluoroquinolones). In addition to providing an overview of the efficiency both in terms of compound removal as well as toxicity reduction, we critically analyze if selected reaction conditions, such as the pH, temperature and water matrix are representative for real-case scenarios. Enzyme immobilization strategies onto inorganic, organic and composite materials are analyzed in terms of their effect on enzyme stability and activity. Their feasibility to be applied in future processes was also evaluated. We found that adequate kinetic description of target compound removal by sufficiently detailed models is still scarce even though it will be key for successful conceptualization of treatment processes. Considering that only a few studies have been conducted at scales above 100 mL, we present the investigated reactor configurations which are at the forefront of further scale-up. The systematic approach presented in this manuscript, which aims to critically evaluate the feasibility to implement enzymatic processes for the removal of antibiotics, can be adapted for other types of recalcitrant compounds targeted by oxidoreductases. Intensified research in the recommended areas will contribute to the development of enzyme-based processes which can complement other advanced wastewater treatment processes.
Graphical abstract
Hinge commitments and trust
Authors: Pritchard Duncan 
Published: October 2023

AbstractAccording to the innovative account of the structure of rational evaluation offered by Wittgenstein in his final notebooks, published as On Certainty, our rational practices necessarily presuppose arational hinge commitments. These are everyday, apparently mundane, commitments that we are optimally certain of, but which in virtue of the ‘hinge’ role that they play in our rational practices cannot themselves enjoy rational support. Granted that there are such hinge commitments, what is the nature of the propositional attitude in play? Many commentators have described this propositional attitude as a kind of trusting, on account of how our hinge commitments are effectively a groundless kind of presupposition. In contrast, I want to push back against this way of thinking about hinge commitments and argue instead that it is crucial to our understanding of Wittgenstein’s proposal especially in terms of its implications for radical scepticism to realize that hinge commitments are not presuppositions and that the hinge propositional attitude is not one of trusting.