bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of Zn-BTC with Different Morphologies of simple synthetic graphene loading and Their Supercapacitor Performance
Authors: tan shangrong , yao zhuo , Liu Zechen , Li Lili 
Published: October 2023

Abstract
The remarkable advantages of supercapacitors, such as high power density, fast charge-discharge rate, and long cycle life, have attracted considerable attention. Metal-organic framework materials (MOFs) have been widely utilized in the field of energy conversion and storage due to their enormous specific surface area and tunable pore structures. However, the poor conductivity of MOFs hinders their satisfactory electrochemical performance when used as electrode materials for supercapacitors. To address this issue, a graphene-supported Zn-BTC metal-organic framework material with different morphologies was successfully synthesized using a simple ultrasonic oscillation method and a one-step solvothermal method. The synthesized one-dimensional rod-shaped Zn-BTC material was uniformly anchored on the wrinkled graphene nanosheet layer, exhibiting excellent capacitance performance with a specific capacitance of 201.3 C g-1 (at 1 A g-1), surpassing that of graphene-supported two-dimensional sheet-like Zn-BTC (152.6 C g-1), graphene-supported three-dimensional spherical Zn-BTC (139.6 C g-1), graphene (108.2 C g-1), and one-dimensional rod-shaped Zn-BTC (63.5 C g-1). By assembling symmetric supercapacitors using graphene-supported one-dimensional rod-shaped Zn-BTC, a maximum energy density of 4.55 Wh kg-1 was achieved at a power density of 104.17 W kg-1, with a specific capacitance retention of 93.26% after 2000 charge-discharge cycles at a current density of 1 A g-1.
Free vibration behaviour of cracked composite sandwich plate: Meta-modelling approach (HOXFEM-ANN)
Authors: Dwivedi Kishan , Raza Ahmed , Pathak Himanshu 
Published: October 2023

AbstractSandwich plates are commonly subjected to transverse shear force during their service and exhibit vibration phenomena. The presence of geometrical discontinuities or fabrication defects like cracks, pores, and holes in the sandwich structure can significantly reduce its stiffness and influence the natural frequency of the plate. This paper proposed a meta-modeling approach based on the higher-order extended finite element method (HOXFEM) and artificial neural network (ANN) to predict natural frequency response of a cracked sandwich plate. A higher-order shear deformation theory (HSDT) is employed for laminated sandwich plates. In the presented HOXFEM method, crack tip enrichment functions are revised for better computational accuracy and computational time. Only four crack tip enrichment functions are proposed in HOXFEM, instead of the eight enrichment functions used in classical XFEM approach. These four enrichment functions consist of two enrichment functions for displacement degrees of freedom and two enrichment functions for rotational degrees of freedom. Further, optimized neural network architecture (4-10-10-10-1) is constructed with data obtained from HOXFEM simulation. The efficacy of the proposed methodology is established through the application of various numerical examples. These examples include different crack sizes and various small cracks/holes configurations within the sandwich plate under different boundary conditions.
Prediction and validation of hub-genes related to major depressive disorder based on co-expression network analysis
Authors: Jalili Shirin , Shirzad Hadi , Nezhad Seyed Amin Mousavi 
Published: October 2023

Abstract
Background
Major depressive disorder (MDD) is generally among the most prevalent psychiatric illnesses. Significant advances have occurred in comprehension of the MDD biology. However, it is still essential to recognize new biomarkers for potential targeted treatment of patients with MDD.
Methods and Results
The present work deals with in-depth comparative computational analyses to obtain new insights, such as gene ontology and pathway enrichment analyses and weighted gene co-expression network analysis (WGCNA) through gene expression dataset. The expression of selected hub-genes was validated in MDD patients using quantitative real-time PCR (RT-qPCR). We found that MDD progression includes the turquoise module genes (p-value = 1e-18, r = 0.97). According to gene enrichment analysis, the cytokine-mediated signaling pathway mostly involves genes in this module. By selection of four candidate hub-genes (IL6, NRG1, TNF, and BDNF), RT-qPCR validation was performed. A significant NRG1 downregulation was revealed by the RT-qPCR outcomes in MDD. In MDD patients, TNF and IL6 expression were considerably higher, and no considerable differences were found in the BDNF expression. Ultimately, based on ROC analyses, IL6, NRG1, and TNF had a higher MDD diagnostic performance.
Conclusions
Therefore, our study presents information on the intricate association between MDD development and cytokine-mediated signaling thus providing new rationales to develop new therapeutic approaches.
Association between Doppler ultrasound of the superior mesenteric artery and different types of shock in critically ill patients
Authors: Pu Hao , Li Wen , Wang Gui , Zhou Shu-Jun 
Published: October 2023

Abstract

Background
Reduced effective circulating blood volume and impaired peripheral perfusion are significant factors in the development of shock. we investigated the differences in superior mesenteric artery (SMA) Doppler ultrasound parameters among different types of shock. Additionally, we evaluated Whether SMA Doppler ultrasound is associated with lactate levels and the ability to predict hyperlactatemia in patients with shock.
Methods
This prospective observational study was conducted at a tertiary general and teaching hospital in China. From January 2023 to August 2023, we included patients who were diagnosed with shock upon admission or developed shock during their hospital stay. At the same time, patients with stable hemodynamics, no use of vasoactive drugs and normal lactate levels were used as a control group. We collected SMA Doppler ultrasound parameters, including Peak Systolic Velocity (PSV), End Diastolic Velocity (EDV), Resistance Index (RI), pulsatility index (PI), Time-Averaged Mean Velocity (TAMV), and Blood Flow (BF).
Results
We evaluated a total of 85 patients, including 63 patients with different types of shock and 22 in the control group. In the cardiogenic shock group, SMA PSV, TAMV, and BF were lower compared to the other groups. There was no significant difference in SMA RI and PI between the different types of shock groups, but both were significantly lower than the control group. Lactate levels was correlation with SMA RI and PI. Based on the lactate level at the time of measurement, we divided the patients into the normal and hyperlactatemia groups. The hyperlactatemia group had lower SMA RI (0.72 ± 0.09 vs. 0.81 ± 0.05, P < 0.0001) and SMA PI (1.60 ± 0.48 vs. 2.22 ± 0.49, P < 0.0001) compared to the lactate normal group. The cut-off value of SMA RI for predicting hyperlactatemia was ≤ 0.78 with a sensitivity of 0.81 and a specificity of 0.79. Similarly, the cut-off value of SMA PI for predicting hyperlactatemia was ≤ 1.79 with a sensitivity of 0.87 and a specificity of 0.74.
Conclusions
SMA Doppler ultrasound plays a significant role in identifying various types of shock, particularly cardiogenic shock. The measurements of SMA RI and PI are correlated with lactate levels, have a positive predictive value for hyperlactatemia and provide guidance for fluid resuscitation in patients with shock in the future.
Online Learning in Supporting Students' Procedural Abilities Viewed from a Constructivist Approach
Authors: Asmara Jimi 
Published: October 2023

Abstract

The aim of the research is to explain the perspective of online learning in supporting students' procedural abilities from a constructivist perspective. This research uses a literature review methodology to describe topics about online learning, procedural abilities and constructivist theory. Scopus article search engines such as Springer Nature, SAGE, Taylor & Francis and Google Scholar provide the collected literature. There are 350 articles covering the search topic. There were 78 additional articles that met the research variables. Selected articles were evaluated together with 47 references. Online learning has features that conform to the fundamental principles of constructivism. The philosophy of constructivism encourages a learning process that places students as the source of the process through concrete empirical and systematic procedural activities. Meanwhile, online learning provides a new model for how the learning process can be carried out without face to face, and can increase students' abilities, especially in terms of practicums which require procedural abilities in each learning process.
PAPSS2 inhibits proliferation and metastasis of papillary thyroid cancer cells by mediating ferroptosis and disulfidptosis through the AKT signaling pathway
Authors: Li Han , Zhang Fuxing , Huang Caoxin , Liu Qiuhong , Li Jia , He Weiwei , Zhang Xiaofang , Gao Jing , Li Ganfeng , Li Xuejun 
Published: October 2023

Abstract
Papillary thyroid cancer (PTC) is the most common type of thyroid cancer(Derwich, Sykutera et al. 2023). Unfortunately, lymph node metastasis often occur in early stage of PTC, while the specific mechanism is still unclear(Wei, Wei et al. 2023). Previous in vivo study showed that PAPSS2 is a rate-limiting enzyme of the sulfation pathway. Interestingly, it has been known that the expression of PAPSS2 in PTC biopsy samples was significantly lower than that in paracancerous tissues. Bioinformatics analysis and preliminary study suggested that PAPSS2 might affect the metabolism of glycosaminoglycan sulfation and damage the extracellular matrix barrier by inhibiting the sulfation pathway, thus providing a suitable microenvironment for tumor metastasis. Our study showed that PAPSS2 could regulate ferroptosis and disulfidptosis of thyroid cancer cells through regulating the AKT signaling pathway and thereby induce cytoskeletal changes and lymph node metastasis. Our findings not only identified a novel therapeutic target but also shed light upon a better understanding of the pathogenesis of PTC.
Pediatric perioperative mortality in Southeastern Nigeria—a multicenter, prospective study
Authors: Nwankwo Elochukwu P , Onyejesi Daniel C , Chukwu Isaac S , Modekwe Victor I , Nwangwu Emmanuel I , Ezomike Uchechukwu O , Omebe Sunday E , Ekenze Sebastian O , Aniwada Elias C 
Published: October 2023

Abstract

Background
The perioperative mortality rate is a key indicator of the quality of surgical services in low and middle-income countries. (LMIC).
Objective
To determine the perioperative mortality rate of pediatric surgical conditions and the predictive factors in Southeastern Nigeria.
Methodology
A prospective, multicenter study of peri-operative mortalities occurring in children under 18 years in five tertiary hospitals in Southeastern Nigeria over nine months was conducted. All-cause and case-specific in-hospital peri-operative mortality rates, and predictive factors were identified. The mortality rate was expressed as percentages with a 95% confidence interval. The data were analyzed using SPSS 26.
Results
A total of 775 patients underwent anesthesia or surgery, with 28 deaths. The perioperative mortality rates within 24 hours and 30 days after the procedure were 1.94% (95% CI = 1.09–3.17) and 1.17% (95% CI = 0.91–2.91) respectively. The mortality rates was 100% for Gastroschisis and ruptured omphalocele with overwhelming sepsis being the major cause of death (53.6%). Significant determinants of mortality were a higher ASA status (AOR) = 13.944, 95% CI = 1.509-128.851, p = 0.020], sedation without ventilatory support (AOR) = 15.295, 95% CI = 3.304–70.800, p = 0.001] and associated comorbidities (AOR) = 65.448, 95% CI = 11.244-380.962, p = 0.001].
Conclusion
The pediatric peri-operative mortality rate in Southeastern Nigeria is high for Gastroschisis. Associated comorbidities, higher ASA status, and sedation without ventilatory support were significant predictors of mortality.
An Intracortical Microprobe with Adaptive Stiffness
Authors: Sharafkhani Naser , Long John M. , Adams Scott D. , Kouzani Abbas Z. 
Published: October 2023

Abstract
Utilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving process is irreversible, any subsequent positioning error cannot be corrected by re-stiffening the microprobe. This study proposes a compliant intracortical microprobe whose equivalent elastic modulus increases because of the axial force applied by an inserter. Thus, instant switching between stiff and soft modes can be accomplished as many times as necessary to ensure high-accuracy positioning while causing minimal tissue damage. The equivalent elastic modulus of the microprobe during operation is ≈ 23 kPa, which is ≈ 42% less than the existing counterpart, resulting in ≈ 46% less maximum strain generated on the surrounding tissue under brain longitudinal motion. The microprobe with adaptive stiffness and surrounding neural tissue are simulated during insertion and operation to confirm the efficiency of the design. Two-photon polymerisation technology is utilised to 3D print the proposed microprobe, which is inserted into a lamb’s brain without buckling.
Characteristics of acute kidney injury in patients with acute decompensation of heart failure
Authors: Davydov V. V. , Arehina E. L. 
Published: October 2023

Introduction. Acute decompensation of heart failure (AHF) can cause acute kidney injury (AKI), hyponatremia, episodes of oliguria and polyuria in the treatment of furosemide. These complications lengthen the time of hospitalization, increase the economic costs of treatment and worsen the prognosis. Currently, the relationship of these manifestations in patients with CHF has not been studied.Objective. To evaluate the effect of AKI on the rate of diuresis and the level of plasma sodium during the complex therapy of AHF.Materials and methods. Kidney function was assessed in 125 patients receiving complex therapy for AHF. The glomerular filtration rate (GFR) was determined in two ways: by the level of creatinine and cystatin C in blood serum. The number of AKI, hyponatremia, episodes of oliguria and polyuria were studied. An analysis of the relationship between these events was carried out.Results. At the time of admission to the hospital, the study of GFR by the level of cystatin C showed 2.6 times more AKI than by the level of creatinine. In total, AKI was found in 22.4% of cases, hyponatremia in 24.8%, episodes of oliguria in 18.4%, episodes of polyuria in 24.8%. The analysis showed that there is a connection of violations of the rate of diuresis and hyponatremia with AKI.Conclusions. Сases of impaired urinary excretion and hyponatremia during AHF therapy are more common in patients with AKI.
Indicators of quality of life, anxiety-depressive symptoms and severity of dysmenorrhea in adolescent girls with peritoneal endometriosis during conservative therapy for a year
Authors: Khashchenko E. P. , Alekseeva M. N. , Uvarova E. V. , Sivirinova A. S. , Salnikova I. A. , Kyurdzidi S. O. 
Published: October 2023

Introduction. Delayed diagnosis and treatment of endometriosis lead to impaired quality of life and pain chronification in young female patients.Aim. To study indicators of quality of life, anxiety, depression and pain syndrome in adolescents with peritoneal endometriosis (PE) over a one-year period of conservative therapy.Materials and methods. A total of 45 girls aged 13 to 17 years with a confirmed diagnosis of PE were enrolled in a prospective longitudinal study. Pain syndrome (VAS, McGill Pain Questionnaire), anxiety-depressive symptoms (Beck Depression Inventory (BDI), Hospital Anxiety and Depression Scale (HADS), Spielberger State-Trait Anxiety Inventory (STAI)), quality of life indicators (SF-36) were assessed before and after one year of treatment in female patients (dienogest administered continuously, NSAIDs and drotaverine for immediate pain relief only).Results. One year of therapy resulted in a significant decrease in the severity of dysmenorrhea and chronic pelvic pain, gastrointestinal symptoms and dysuria, daily activity and productivity impairment (p < 0.001) in girls with PE. In addition, the study demonstrated decreased indicators of anxiety and depressive disorders (BDI depression, HADS anxiety and depression, STAI reactive and personal anxiety (p < 0.001)) and an improvement in quality-of-life indicators (physical and psychological component, average index (p < 0.001)). There was a declining trend in blood hormone and inflammation test results within the reference range during treatment. The estradiol level has been shown to be a risk factor for high levels of affective disorder symptoms in adolescents with PE: STAI reactive anxiety (p = 0.046), HADS anxiety and depression (p = 0.044 and 0.033, respectively).Conclusion. The one-year therapy of PE in adolescents (dienogest administered continuously, a combination of NSAIDs and drotaverine in pain syndrome only) was associated with significantly improved quality of life, decreased severity of anxietydepressive disorders and pain, which confirms the need to start therapy when symptoms of the disease begin to show them-selves in adolescence.
Left ventricular myocardial hypertrophy and strain changes in children with hypertrophic cardiomyopathy
Authors: Chernykh N. Yu. , Tarasova A. A. , Groznova O. S. 
Published: October 2023

Introduction. An assessment of the relationship between the severity of hypertrophy and changes in the myocardial strain at which systolic disfunction is detected in children with hypertrophic cardiomyopathy (HCM) is clearly essential.Aim. To assess the relationship between hypertrophy and the myocardial strain in children with hypertrophic cardiomyopathy (HCM).Materials and methods. 61 patients aged between 7 and 17 years with a primary form of HCM underwent an ultrasound examination of the heart using standard techniques. An assessment of the left ventricular systolic function performed using of-line the two-dimensional (2D) speckle-tracking mode with analysis parameters that included global and segmental longitudinal, circumferential, and radial myocardial strains. The analysis of hypertrophy of myocardial segments carried out taking into account the absolute values of the thickness of the left ventricular myocardium in systole and diastole, depending on age, in terms of standard deviation units in the population (Z-score factor).Results. A decrease in longitudinal strain below the relevant values, an increase in radial strain, and no changes in circular strain were observed when the thickness of the left ventricular myocardium increased over 2.48Z. A further decrease in radial strain was observed when myocardial thickness was over 4.24Z, and circular strain was over 3.16Z. The relationship between myocardial hypertrophy and longitudinal strain had an inverse linear relationship: the lower the strain values, the greater the thickness of the myocardium. With increasing thickness of the myocardium, the radial strain first tended to increase in a compensatory manner, but it decreased when myocardial thickness increased over 4.24Z. The circular strain, as well as longitudinal one, has an inverse linear relationship, but with longer preservation of normal values when myocardial hypertrophy increases.Conclusion. Children with HCM demonstrate various types of relationships between hypertrophy and myocardial strain, which detection is important for the assessment of the left ventricular systolic function to improve the prognosis and therapeutic approach to the disease. A comprehensive approach to the assessment of myocardial strain in children with HCM should include not only a routine identification of global strain, but also assessment of the segmental strain to detect early signs of myocardial dysfunction. Comparison of measures of various types of strain and the thickness of the left ventricular myocardium has a very important diagnostic value for understanding the degree of changes in its kinetics.
The effect of vitamin D on the early clinical manifestations of menopausal syndrome and the production of cytokines, involved in bone remodeling
Authors: Maylyan E. A. , Lesnichenko D. A. , Dzhelomanova E. S. , Reznichenko N. A. , Prilutskii A. S. , Bagriy A. E. , Trunova O. A. , Prokhorov E. V. 
Published: October 2023

Introduction. The problem of early manifestations of menopausal syndrome is due to the high prevalence among postmenopausal women, a wide range of clinical manifestations, a sharp decrease in the quality of life, not always sufficient effectiveness of menopausal hormone therapy (MHT) in the presence of restrictions on its use.The aim. To evaluate the dynamics of clinical manifestations of menopausal syndrome and to determine the pathogenetic effects of vitamin D preparation when used in combination with menopausal hormone therapy in women of early postmenopausal age with menopausal syndrome.Materials and methods. 154 women were examined, of which 81 were characterized by the presence of clinical manifestations of menopausal syndrome. All women with menopausal syndrome received menopausal hormone therapy with estradiol and didrogesterone drug for 6 months, while 39 women additionally also took the vitamin D drug. Before and after therapy in patients with menopausal syndrome, the prevalence of symptoms of the Green scale was assessed. Concentrations of 25(OH) D, osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) were determined in the blood serum of all women.Results and discussion. The use of MHT by women with menopausal syndrome leads to a decrease in the frequency of registration of a number of symptoms of the Green scale (p < 0.05). At the same time, a decrease in the frequency of registration of individual complaints is found only in the group of women who, along with MYT, received a vitamin D preparation (p < 0.05). Taking the vitamin D preparation is accompanied by an increase in its initially reduced serum concentrations to normal values (p < 0.001). The addition of cholecalciferol to the complex therapy of menopausal syndrome ensures the normalization of RANKL levels by reducing its production in the dynamics of treatment (p < 0.05) A decrease in the concentration of RANKL in response to the complex intake of a hormonal drug and cholecalciferol caused higher OPG/RANKL index values in the basic group by the end of therapy than in women of the comparison group (p < 0.01).Conclusions. The obtained effects of vitamin D preparation when prescribed in combination with menopausal hormone therapy (reduction of the frequency of symptoms of menopausal syndrome, reduction of initially elevated levels of RANKL) indicate the expediency of its use in the treatment of early manifestations of menopausal syndrome.