bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into Healthcare Design Essentials from Diverse Perspectives
Authors: Wells‐Papanek Doris 
Published: February 2024

Much work is yet to be done to transform gaps in services by designing more equitable, accessible, affordable, and empathy‐based healthcare best practices for all humans.Consider how to use meaningful imagery, purposeful storytelling, and intentional problem‐solving to address the new and changing healthcare landscape in order to create a more sustainable, patient‐centered experience.
Using the Design Culture Framework to Identify Value
Authors: Rodríguez Rodrigo Martínez , Gago Paula Fernández 
Published: February 2024

Measuring the value of design remains an obsession for researchers and academics as well as an area of continuous development of models and theories within business management.How do we measure the value of design? This article looks at the perception of design at different organizational levels and its role in strategic business management, looking specifically at the Design Culture Framework.
Recombinant factor IX Fc for the treatment of hemophilia B
Authors: Ljung Rolf , Matino Davide , Shapiro Amy D. 
Published: February 2024

AbstractCurrent hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half‐life (EHL) products that provide effective bleed protection when administered at intervals of 7 days or longer. rFIXFc is a recombinant fusion protein with an extended circulation time. rFIXFc has a biodistribution profile consistent with distribution into extravascular space, where it may support hemostasis at sites of vessel injury independent of circulating plasma activity levels. The safety and efficacy of rFIXFc prophylaxis is well established in adults, adolescents and children including previously untreated patients with hemophilia B, with substantial evidence from clinical trials and real‐world clinical practice. This review describes the pharmacokinetic characteristics of rFIXFc, summarizes available safety and efficacy data, and evaluates the use of rFIXFc in special populations. Current hemophilia B treatment challenges, including target FIX plasma levels, perioperative use, and management of patients with comorbidities, are discussed together with the potential role of EHL products in the future treatment landscape of hemophilia B.
“The spirit of a fighter”: Mixed‐status Latine immigrant families' experiences during COVID
Authors: Vesely Colleen K. , Letiecq Bethany , Davis Elizabeth , Goodman Rachael , DeMulder Elizabeth , Marquez Marlene ,   Amigas de la Comunidad
Published: February 2024

AbstractObjectiveUsing a community‐based participatory research (CBPR) approach, this study documents Latine immigrant families' work, childcare, and education experiences during the COVID‐19 pandemic to inform policy and practice to support Latine families.BackgroundLatine immigrant communities, comprising undocumented and mixed‐status families, were among the hardest hit by the COVID‐19 pandemic. In addition to employment and housing challenges, children and families lost access to the important academic supports and social services built into childcare programs and schools.MethodFor this study, we collected in‐depth qualitative interview data from mothers who were immigrants from Central America and Mexico (N = 23) as part of an ongoing CBPR project. Using community coding techniques, data were analyzed in partnership with our Community Advisory Board, Amigas de la Comunidad.ResultsIn the context of illegality, participants and their families who already feared deportation and family separation, faced added burdens during the pandemic including job loss, school and childcare closures, and isolation. Parents worried about meeting their families' basic needs, getting sick, losing loved ones to COVID‐19, and being evicted from their housing.ConclusionWhile participants shared stories of resilience and resistance, they also reflected on stories loss and hardship—experiences that were exacerbated by anti‐immigrant laws and policies that made navigating the pandemic especially punishing for immigrant families.ImplicationsOn the basis of study findings, program and policy implications for serving Latine children and youth and their immigrant parents, especially those with mixed documentation status, are discussed.
Children's socioemotional skills and fathers' work satisfaction: Mediation of fathers' parenting
Authors: Gong Qiujie , Ju Sehyun , Kramer Karen Z. 
Published: February 2024

AbstractObjectiveIn this study, we examined the bidirectional association between fathers' work satisfaction and children's socioemotional skills from T1 (age 2) to T2 (age 4–5) and the mediating role of fathers' parenting.BackgroundFor many parents, balancing family and work roles can be challenging, particularly for fathers who are now expected to be both “ideal workers” and “involved fathers.” With multiple roles, fathers' experiences at work and in the family may have a mutual influence on each other.MethodThis study used structural equation modeling on secondary data from the Early Childhood Longitudinal Study, Birth Cohort, to examine the associations and mediation mechanisms.ResultsResults indicate a positive association between fathers' work satisfaction at T1 and children's socioemotional skills at T2 through fathers' higher self‐efficacy and lower parenting stress. Additionally, there was a positive association between children's socioemotional skills at T1 and fathers' work satisfaction at T2 through fathers' higher responsibility and lower parenting stress.ConclusionFindings provide support for the spillover theory regarding the mutual influence of fathers' work‐related experiences and children's development.ImplicationsTo help parents balance the demands of work and family, effective parenting education programs and supportive or person‐centered workplace policies are both essential.
Over two decades of research on choice overload: An overview and research agenda
Authors: Jacob Breeze Mary , Thomas Sam , Joseph Joshy 
Published: February 2024

AbstractSince Alwin Toffler coined the term choice overload in 1970, no systematic literature review has been conducted on this subject. At the same time, the three meta‐analytic studies available on the topic does not provide a comprehensive picture of the same. This systematic literature review seeks to critically evaluate the extant research on choice overload for 22 years using insights from 92 articles. After locating the major articles in the choice overload literature, we identified the theories used by researchers to explain the various aspects of choice overload, based on the TCCM framework. We then enlisted the contexts where the studies had been conducted, the characteristics (themes) of the studies, and the methodologies used in these articles. We further identified the relationships between the themes, the variables studied so far, the sampling types and sampling sizes and the statistical tools employed in these studies. Future researchers could investigate the impact of a variety of cognitive and affective factors that impact consumer psychological states and the likelihood of choice saturation. They could also focus on unexplored areas in the field of choice overload, such as comparing the effects of choice overload in physical and online contexts.
How can valid and reliable automatic formative assessment predict the acquisition of learning outcomes?
Authors: Divjak Blaženka , Svetec Barbi , Horvat Damir 
Published: February 2024

AbstractBackgroundSound learning design should be based on the constructive alignment of intended learning outcomes (LOs), teaching and learning activities and formative and summative assessment. Assessment validity strongly relies on its alignment with LOs. Valid and reliable formative assessment can be analysed as a predictor of students' academic performance, but the question is how significant its predictive power is, and what other elements can affect predictions.ObjectivesOur aim was to investigate the predictive power of formative assessment for summative assessment, measuring the acquisition of LOs.MethodsWe analysed formative assessment results (quizzes, homework), together with log data (video and other material use, class attendance), to determine the most influential predictors and establish a reliable predictive learning analytics model. We used the Random Forest algorithm. The model is based on the data from two university mathematical courses, delivered at different years and levels of study, incorporating 813 students in two consecutive years.Results and ConclusionsOur results show that formative assessment, together with previous summative assessment, is a stronger predictor of summative assessment results than other data on students' engagement. The study pointed to the importance of completeness and quality of data, and clear links between assessment and LOs when making predictions of student results. It suggested that predictions are less reliable for the lowest and the highest performing students. It was noted that other factors can also affect predictions, like the level of LOs, or factors not easily extracted from digital data, like the learning environment and individual students' strategies.
Using digital gamification to improve language achievement, foreign language enjoyment, and ideal L2 self: A case of English as a foreign language learners
Authors: Liu Gi‐Zen , Fathi Jalil , Rahimi Masoud 
Published: February 2024

AbstractBackgroundThe impact of digital gamified language learning on language achievement has been corroborated in the literature; however, its impact on language achievement, especially in the English as a foreign language (EFL) context needs further investigation. In addition, the related literature has not sufficiently confirmed the impact of digital gamified language learning on some psychological domains of EFL learning.ObjectivesThis study, therefore, employed a sequential explanatory mixed‐methods approach to explore the effects of digital gamified language learning using a mobile application (app) affordances on EFL learners' language achievement, foreign language enjoyment (FLE), and ideal second language (L2) self.MethodsTo this end, 36 EFL learners were randomly divided into two groups; one group was randomly assigned to the digital class, including 19 EFL learners, and the other group was assigned to the non‐digital class, consisting of 17 EFL learners. The digital learners did the digital gamified language learning activities individually and interactively and received peer and instructor feedback, whilst the non‐digital learners did the same language learning activities in printed format and received peer and instructor feedback. A language achievement test, the FLE scale, and the ideal L2 self‐scale were used to collect the quantitative data and an individual semi‐structured interview was carried out to gather the qualitative data.Results and ConclusionsOne‐way ANCOVA, used to analyse the quantitative data, revealed that the digital and non‐digital classes improved the EFL learners' language achievement, FLE, and ideal L2 self; however, the digital learners outperformed their non‐digital counterparts in all the measures. Thematic analysis, utilised to analyse the qualitative data, uncovered some themes about the digital learners' positive and negative attitudes and perceptions towards the digital gamified language learning activities, clarifying the quantitative findings.ImplicationsPedagogical implications are discussed.
Unveiling the positive impact of biofloc culture on Vibrio parahaemolyticus infection of Pacific white shrimp by reducing quorum sensing and virulence gene expression and enhancing immunity
Authors: Widanarni Widanarni , Gustilatov Muhamad , Ekasari Julie , Julyantoro Pande Gde Sasmita , Waturangi Diana Elizabeth , Sukenda Sukenda 
Published: February 2024

AbstractThis study aimed to evaluate and unveil the positive impact of biofloc culture on Vibrio parahaemolyticus infection of Pacific white shrimp by reducing quorum sensing (QS) and virulence gene expression and enhancing shrimp's immunity. The shrimp with an average body weight of 0.50 ± 0.09 g were reared in containers with a volume of 2.5 L, 21 units, and a density of 20 shrimp L−1. The shrimp were cultured for 5 days, with each treatment including biofloc system maintenance with a C/N ratio of 10 and a control treatment without biofloc, followed by a challenge test through immersion using V. parahaemolyticus at densities of 103, 105, and 107 CFU mL−1 initially. The results of the in vitro experiment showed that biofloc suspension can inhibit and disperse biofilm formation, as well as reduce the exo‐enzyme activity (amylase, protease, and chitinase) of V. parahaemolyticus. Furthermore, the biofloc treatment significantly reduced the expression of the QS regulatory gene OpaR, the PirB toxin gene, and the virulence factor genes T6SS1 and T6SS2 in both in vitro and in vivo. The biofloc system also increased the expression of shrimp immunity‐related genes (LGBP, proPO, SP, and PE) and the survival rate of white shrimp challenged with V. parahaemolyticus.
Metabolic‐associated fatty liver disease and hepatocellular carcinoma: a prospective study of characteristics and response to therapy
Authors: Batt NM , Rodrigues B , Bloom S , Sawhney R , George ES , Hodge A , Vootukuru N , McCrae C , Sood Surbhi , Roberts SK , Dev A , Bell S , Thompson A , Ryan MC , Kemp W , Gow PJ , Sood Siddharth , Nicoll AJ 
Published: February 2024

AbstractBackground and AimThe rising incidence of hepatocellular carcinoma (HCC) in Australia is related to increasing rates of metabolic‐associated fatty liver disease (MAFLD). This study aimed to prospectively characterize the metabolic profile, lifestyle, biometric features, and response to treatment of HCC patients in an Australian population.MethodMulticenter prospective cohort analysis of newly diagnosed HCC patients at six multidisciplinary team meetings over a 2‐year period.ResultsThree hundred and thirteen (313) newly diagnosed HCC patients with MAFLD (n = 77), MAFLD plus other liver disease (n = 57) (the “mixed” group), and non‐MAFLD (n = 179) were included in the study. Alcohol‐associated liver disease (ALD) (43%) and MAFLD (43%) were the most common underlying liver diseases. MAFLD‐HCC patients were older (73 years vs 67 years vs 63 years), more likely to be female (40% vs 14% vs 20%), less likely to have cirrhosis (69% vs 88% vs 85%), showed higher ECOG, and were less likely to be identified by screening (29% vs 53% vs 45%). Metabolic syndrome was more prevalent in the MAFLD and mixed groups. The severity of underlying liver disease and HCC characteristics were the same across groups. While the MAFLD population self‐reported more sedentary lifestyles, reported dietary patterns were no different across the groups. Dyslipidemia was associated with tumor size, and those taking statins had a lower recurrence rate.ConclusionEqual to ALD, MAFLD is now the most common underlying liver disease seen in HCC patients in Australia. Future HCC prevention screening and treatment strategies need to take this important group of patients into consideration.
GaN atomic electric fields from a segmented STEM detector: Experiment and simulation
Authors: Grieb Tim , Krause Florian F. , Mehrtens Thorsten , Mahr Christoph , Gerken Beeke , Schowalter Marco , Freitag Bert , Rosenauer Andreas 
Published: February 2024

SummaryAtomic electric fields in a thin GaN sample are measured with the centre‐of‐mass approach in 4D‐scanning transmission electron microscopy (4D‐STEM) using a 12‐segmented STEM detector in a Spectra 300 microscope. The electric fields, charge density and potential are compared to simulations and an experimental measurement using a pixelated 4D‐STEM detector. The segmented detector benefits from a high recording speed, which enables measurements at low radiation doses. However, there is measurement uncertainty due to the limited number of segments analysed in this study.
Choosing to Disagree: Endogenous Dismissiveness and Overconfidence in Financial Markets
Authors: BANERJEE SNEHAL , DAVIS JESSE , GONDHI NAVEEN 
Published: February 2024

ABSTRACTThe psychology literature documents that individuals derive current utility from their beliefs about future events. We show that, as a result, investors in financial markets choose to disagree about both private information and price information. When objective price informativeness is low, each investor dismisses the private signals of others and ignores price information. In contrast, when prices are sufficiently informative, heterogeneous interpretations arise endogenously: most investors ignore prices, while the rest condition on it. Our analysis demonstrates how observed deviations from rational expectations (e.g., dismissiveness, overconfidence) arise endogenously, interact with each other, and vary with economic conditions.
Justice suspended: Rethinking institutions, regimentation, and channels from a human rights law perspective
Authors: Greenberg Jessica R. 
Published: February 2024

AbstractThis article analyzes institutions as sites for political and social change by looking beyond regimentation and fixedness as the central discursive features of institutionalization. Drawing on research at the European Court of Human Rights—one of the world's most extensive human rights courts—I analyze how human rights actors redeploy normative institutional logics through creative approaches to institutional categories. I argue that lawyers and advocates working within the Court and Convention system naturalize and fix boundaries of law and politics and use that distinction to activate an excess of potential meanings and intertextual connections in legal judgments. This involves using institutional affordances to keep cases open and structure collaborative waiting. These strategies allow people to mutually inhabit open‐ended relationships to texts in intentional ways. In so doing, lawyers and activists defer resolving legal judgments—until new coalitions take political power, there are generational shifts in attitudes or shifts in geopolitical power arrangements that render state actors subject to diplomatic pressure. Analyzing how people improvise, learn, and teach others to manage institutional channels and excess opens up the black box of institutionality as a site for social transformation.
Effect of various surface treatments on relining bond strength of CAD‐CAM denture base materials
Authors: Karaokutan Isil , Ayvaz Ilayda 
Published: February 2024

AbstractPurposeThe aim of this study was to analyze the impact of various surface treatments and production methods on the shear bond strength (SBS) between reline material and denture base resins.Materials and MethodsOne‐hundred‐twenty specimens were produced using conventional heat‐polymerization, subtractive, and additive techniques. Each group consisted of 40 specimens. The specimens were divided into four subgroups, each with 10 samples, for surface treatments. These subgroups were: (1) Control‐only monomer application, (2) 50 μm airborne‐particle abrasion, (3) 110 μm airborne‐particle abrasion, and (4) Roughening with tungsten carbide bur. Representative specimens from each subgroup were examined under SEM. Then, auto‐polymerized resin was condensed in the center of the specimens. Specimens were subjected to thermal aging (5000 cycles at 5–55°C). The SBS test was conducted and failure loads were recorded. The data were evaluated by two‐way ANOVA and Tukey pairwise multiple comparisons method (p < 0.05).ResultsThe additively produced group showed significantly lower SBS than conventional and subtractive groups (p < 0.001), with no significant differences between the subtractive and conventional groups. Specimens that underwent monomer application only showed the lowest SBS among surface treatments, while 50 μm airborne‐particle abrasion showed the highest SBS. Based on the partial eta‐squared analysis results, the surface treatment mainly impacted SBS.ConclusionsAmong the surface treatment methods, treating denture bases with 50 μm airborne‐particle abrasion is more effective for maintaining adhesion, especially in the additive technique.
Directionality explored: Black Adolescents' awareness of systemic racism and race‐based experiences
Authors: Johnson Natasha C. , Rowley Stephanie J. , Kurtz‐Costes Beth 
Published: February 2024

AbstractIncreases in conversations about race and racial discrimination experiences during adolescence make this a critical developmental period to investigate adolescents' awareness of racism. We examined bidirectional associations between race‐based experiences and awareness of systemic racism—operationalized as understanding systemic causes of racial disparities in education. Adolescents who self‐identified as African American/Black were surveyed in Grade 6 (n = 317; Mage = 11.12; 48% girls) and Grade 8 (n = 247; Mage = 13.15; 56% girls). Cross‐lagged panel analyses revealed that racial barrier messages, but not racial discrimination experiences, in Grade 6 positively predicted awareness of systemic racism in Grade 8. Adolescents' awareness of systemic racism in Grade 6 did not predict racial socialization or racial discrimination experiences in Grade 8.
Dietary pterostilbene exerts potential protective effects by regulating lipid metabolism and enhancing antioxidant capacity on liver in broilers
Authors: Zhang Licong , Zhang Jingyang , Zang Haoran , Yin Zesheng , Guan Peiyue , Yu Chunting , Shan Anshan , Feng Xingjun 
Published: February 2024

AbstractIntensive breeding of broilers met the increasing demands of human for broiler products, but it raised their increased susceptibility to various stressors resulting in the disorder of lipid metabolism. Pterostilbene, the methoxylated analogue of resveratrol, exhibits astonishing functions of antioxidant, anti‐inflammatory and glycolipid regulatory. The study aimed to elucidate the protective effects of pterostilbene on broiler liver and to explore the potential mechanisms. A total of 480 one‐day‐old male Arbor Acres (AA) broilers were randomly divided into four groups: the control group (basal diet) and pterostilbene groups (PT200, PT400, and PT600 feeding with basal diet containing 200, 400 and 600 mg/kg pterostilbene, respectively). The results showed that the dietary pterostilbene supplementation significantly improved the ADG of broilers. Dietary pterostilbene supplementation regulated the expression levels of the genes Sirt1 and AMPK and the downstream genes related to lipid metabolism to protect liver function and reduce lipid accumulation in broilers. Dietary pterostilbene supplementation upregulated the expression levels of the Nrf2 gene and its downstream antioxidant genes (SOD, CAT, HO‐1, NQO‐1, GPX) and phase II detoxification enzyme‐related genes (GST, GCLM, GCLC). Collectively, pterostilbene was confirmed the positive effects as a feed additive on lipid metabolism and antioxidant via regulating Sirt1/AMPK and Nrf2 signalling pathways in broilers.