bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization of GPT-4 to Improve Education Quality Through Personalized Learning for Generation Z in Indonesia
Authors: Firdaus Muhammad Fatihul , Wibawa Joseph Nugraha , Rahman Fajri Fathur 
Published: October 2023

<p><strong>The Golden Generation or Generation Z, an important part of the 2020-2035 demographic bonus, will face unique educational challenges, such as low literacy rates and uneven access to technology across regions</strong>[1]<strong>. To support the potential implementation of personalized learning for Generation Z in Indonesia, a research study was conducted to investigate the potential use of GPT-4, an artificial intelligence that uses the GPT language model and the latest Natural Language Processing (NLP) technology. Quantitative, qualitative, and literature study research methods were used to evaluate the effectiveness and accuracy of GPT-4 in the Indonesian educational context. Data was collected from sample testing and reference to previous GPT-4 research, and results were analyzed using predefined evaluation methods. The results of the analysis showed that there was an improvement in terms of coherence and knowledge with the GPT-4 model compared to previous models. To maximize the potential of GPT-4 in education, there needs to be strong support from various parties, as well as efficient adaptation to the specific needs of students and the educational environment in Indonesia </strong>[2]<strong>. With an integrated approach, ethics, and safety, GPT-4 has the potential to support inclusive and effective education for Generation Z in Indonesia. </strong></p>
Air Traffic Demand Forecasting with a Bayesian Structural Time Series Approach
Authors: Rodríguez Yesid , Díaz Olariaga Oscar 
Published: October 2023

Airport planning, and therefore the development of air infrastructure, depends to a large extent on the demand forecast for the future. To plan investments in the infrastructure of an airport system and to be able to meet future needs, it is essential to predict the level and distribution of demand, both for passengers and air cargo. In the present work, a forecast was made, in the medium-long term (10 years), of the demand for passengers and air cargo, applied to a specific case study (Colombia), and where the impact on air traffic during the most severe period of the COVID-19 pandemic was taken into account. To achieve this objective, and as a methodological approach, a model of the Bayesian Structural Time Series (BSTS) type was developed, designed to work with time series data, and widely used for feature selection, time series forecasting, and the immediate inference of the causal impact. From the results obtained, two relevant aspects can be highlighted, firstly, both demand and its growth trend will recover very soon (in just a couple of years), compared to the pre-pandemic year 2019, which was analyzed in the case study. And, secondly, the model presents very acceptable MAPE values (between 1% and 7%, depending on the variable to be forecasted), which makes the BSTS method a viable alternative methodology for calculating air traffic forecasts.
Determinants of Caesarean Section in Bangladesh: A Multilevel Analysis of BDHS 2017-2018 Data
Authors: Haque M Ershadul , Sharmin Sabina , Sharmin Sayema 
Published: October 2023

In recent years Caesarean Section (C-S)is considered as an important mode of child delivery in lowering mother and infant mortality. However, the unnecessary use of C-S has detrimental impacts on both mothers’ and newborns’ health. The purpose of this study is to evaluate the prevalence of caesarean delivery and to find out the related factors influencing the rapid rise in C-Sin Bangladesh by considering an appropriate statistical model in line with the data structure. The study is based on the data from the 2017-2018 BDHS which is a nationally representative survey. BDHS is conducted periodically and 2017-2018 is the latest of all the BDHS conducted so far. Information used in the present study was collected from 5230 mothers who provided complete information about all the variables considered in the study. Among the Bangladeshi women, the rate of Caesarean sections (C-S) was reported to be 32.94% which is high in any international standard. Multilevel analysis suggests that the highest education level, current working status, wealth index, media exposure, number of decisions in which women participated, age at birth, BMI, birth order of the index child, number of ANC visits during the period of pregnancy, and childbirth weight have significant influence on whether mothers deliver babies through the C-S. In order to prevent needless caesarean deliveries and safeguard mothers from the consequences, Bangladesh urgently needs caesarean delivery policy guidelines. The study will help the policymaker in taking such initiatives.
Dhaka Univ. J. Sci. 71(2): 117-126, 2023 (July)
Implementasi IoT Pada Sistem Pembayaran di Koperasi Sekolah
Authors: Silalahi Mesri , Saragih Saut Pintubipar 
Published: October 2023

Information technology has been widely adopted by numerous educational institutions, both formal and informal, based on religion or non-religious, The urgency of innovative technologi which appliable to school business processes are rising rapidly within enormous applicable internet of Things available. The research methodology in this research conducted comprehensively. Researcher will used the technolgu of Microcontroller Esp32 to help the implementation of payment in one of the department of the research object. Developing the system within the school system will need very trmendous effort to justify the system accepted by all the stakeholder. Researcher using the srum methods in software development and using the esp32 microcontroller as the thechologu to merged within, researcher hope the capablity of Background Subtraction Algorithm on ESP32, it is elucidated that the background subtraction algorithm can be implemented on the ESP32 device. This device possesses the capability to process image frames measuring 80 x 60 pixels a total of 10,000 times within a temporal span of 2,000 milliseconds (at an approximate rate of ±5,000 frames per secondThe result of this research supposedly achieve the implementation of the microcontroller technology to provide the solution in school business unit payment processes. All the visitor to the business unit are detected with the RFID card using the microcontroller to automate the identification and enabling better transaction process flow.
GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis
Authors: Nagenborg Jan , Jin Han , Ruder Adele V. , Temmerman Lieve , Mees Barend , Schalkwijk Casper , Müller-Klieser Daniel , Berg Thorsten , Goossens Pieter , Donners Marjo M. P. C. , Biessen Erik A. L. 
Published: October 2023

IntroductionInhibition of STAT5 was recently reported to reduce murine atherosclerosis. However, the role of STAT5 isoforms, and more in particular STAT5A in macrophages in the context of human atherosclerosis remains unknown.Methods and resultsHere, we demonstrate reciprocal expression regulation of STAT5A and STAT5B in human atherosclerotic lesions. The former was highly upregulated in ruptured over stable plaque and correlated with macrophage presence, a finding that was corroborated by the high chromosomal accessibility of STAT5A but not B gene in plaque macrophages. Phosphorylated STAT5 correlated with macrophages confirming its activation status. As macrophage STAT5 is activated by GM-CSF, we studied the effects of its silencing in GM-CSF differentiated human macrophages. STAT5A knockdown blunted the immune response, phagocytosis, cholesterol metabolism, and augmented apoptosis terms on transcriptional levels. These changes could partially be confirmed at functional level, with significant increases in apoptosis and decreases in lipid uptake and IL-6, IL-8, and TNFa cytokine secretion after STAT5A knockdown. Finally, inhibition of general and isoform A specific STAT5 significantly reduced the secretion of TNFa, IL-8 and IL-10 in ex vivo tissue slices of advanced human atherosclerotic plaques.DiscussionIn summary, we identify STAT5A as an important determinant of macrophage functions and inflammation in the context of atherosclerosis and show its promise as therapeutic target in human atherosclerotic plaque inflammation.
NKG2D-CAR memory T cells target pediatric T-cell acute lymphoblastic leukemia in vitro and in vivo but fail to eliminate leukemia initiating cells
Authors: Ibáñez-Navarro Marta , Fernández Adrián , Escudero Adela , Esteso Gloria , Campos-Silva Carmen , Navarro-Aguadero Miguel Ángel , Leivas Alejandra , Caracuel Beatriz Ruz , Rodríguez-Antolín Carlos , Ortiz Alejandra , Navarro-Zapata Alfonso , Mestre-Durán Carmen , Izquierdo Manuel , Balaguer-Pérez María , Ferreras Cristina , Martínez-López Joaquín , Valés-Gómez Mar , Pérez-Martínez Antonio , Fernández Lucía 
Published: October 2023

IntroductionRefractory/relapsed pediatric acute leukemia are still clinically challenging and new therapeutic strategies are needed. Interactions between Natural Killer Group 2D (NKG2D) receptor, expressed in cytotoxic immune cells, and its ligands (NKG2DL), which are upregulated in leukemic blasts, are important for anti-leukemia immunosurveillance. Nevertheless, leukemia cells may develop immunoescape strategies as NKG2DL shedding and/or downregulation.MethodsIn this report, we analyzed the anti-leukemia activity of NKG2D chimeric antigen receptor (CAR) redirected memory (CD45RA-) T cells in vitro and in a murine model of T-cell acute lymphoblastic leukemia (T-ALL). We also explored in vitro how soluble NKG2DL (sNKG2DL) affected NKG2D-CAR T cells’ cytotoxicity and the impact of NKG2D-CAR T cells on Jurkat cells gene expression and in vivo functionality.ResultsIn vitro, we found NKG2D-CAR T cells targeted leukemia cells and showed resistance to the immunosuppressive effects exerted by sNKG2DL. In vivo, NKG2D-CAR T cells controlled T cell leukemia burden and increased survival of the treated mice but failed to cure the animals. After CAR T cell treatment, Jurkat cells upregulated genes related to proliferation, survival and stemness, and in vivo, they exhibited functional properties of leukemia initiating cells.DiscussionThe data here presented suggest, that, in combination with other therapeutic approaches, NKG2D-CAR T cells could be a novel treatment for pediatric T-ALL.
A measurement-to-modelling approach to understand catchment-to-reef processes: sediment transport in a highly turbid estuary
Authors: Xiao Ziyu , Carlin Geoffrey , Steven Andrew D. L. , Livsey Daniel N. , Song Dehai , Crosswell Joseph R. 
Published: October 2023

As sediments carried by rivers enter coastal waters, fine particles can reduce the amount of light that reaches the reef through light attenuation. The Fitzroy Estuary - Keppel Bay (FE-KB), being the second-largest source of sediments to the Great Barrier Reef (GBR) poses a significant threat to the GBR ecosystem such as coral reefs and seagrass meadows, and biogeochemical cycles that influence water clarity. While monitoring and modelling capabilities for catchment and marine settings are now well-developed and operational, a remaining key gap is to better understand and model the transport, dynamics and fate of catchment derived material through tidally influenced sections of rivers that discharge into the GBR. This study aims to reveal sediment transport in the FE-KB estuary by continuously monitoring the seasonal variability over a year-long period and build a high-resolution model to predict sediment budgets under different scenarios of physical forcing and river conditions. Multiple data sources, including field surveys, historical data, and numerical modelling were used to obtain a detailed understanding of the sediment transport processes during wet (high river flow) and dry (low-to-no river flow) seasons. The use of high-resolution bathymetry and survey data for sediment model parameterization allowed for accurate mapping of the morphological changes, while numerical modeling provided insights into the hydrodynamic and sediment transport processes in the estuary. Observation and model data confirm the existence of a Turbidity Maximum Zone (TMZ) in the FE-KB (approximately 35 – 40 km from estuary head), where the topography plays a critical role in trapping sediments. By utilizing the model, a closed sediment budget was calculated under varying flow conditions and the results were used to determine the estuarine trapping coefficient that ranges from 28% (during extreme wet condition) to 100% (during dry condition) of the total catchment loads. Morphodynamic modelling demonstrated a persistent erosion pattern in the upper reach of the FE. The lower FE and southern tidal creeks serve as a large sediment storage basin during both wet and dry seasons, and sediment is exported and deposited offshore during high river flow conditions.
Screening for latent infectious disease in patients with alopecia areata before initiating JAK inhibitors therapy: a single-center real-world retrospective study
Authors: Huang Jundong , Tan Zixin , Tang Yan , Shi Wei 
Published: October 2023

IntroductionAlthough there is growing evidence supporting the effectiveness of Janus kinase (JAK) inhibitors in treating alopecia areata, the high rate of recurrence following drug discontinuation has led to prolonged treatment courses and raised concerns about long-term safety. In clinical practice, caution should be exercised while using JAK inhibitors for various indications, and a comprehensive pre-treatment screening.MethodsThis study presents an analysis of screening data collected from real-world settings before the initiation of Janus kinase inhibitors in patients with alopecia areata. Investigators collected retrospective medical data characterizing patients’ screening data. Data on demographic and clinical data, including age, sex, disease duration, severity of alopecia tool scale, history of prior treatment, and treatment regimen were recorded.ResultsIn this cohort (N = 218), JAK inhibitors were initiated for 163 of 218 (74.8%) alopecia areata patients. The numbers of patients positive for antinuclear antibodies, hepatitis B surface antigen, hepatitis C virus antibodies, human immunodeficiency virus antibody, treponema pallidum hemagglutination assay, and thyroid-stimulating hormone were 32 (32/176), 10(10/218), 0 (0/218), 0 (0/218), 3 (3/218) and 9 (9/176), respectively. The number of patients with T-cell spot positive or imaging of the chest indicating tuberculosis was 37 (37/218).DisccusionOur data provide additional information on the safety profile of JAK inhibitors in patients with alopecia areata. As such, it is necessary and crucial to screen for JAK inhibitors before it is used, particularly for individuals with a high risk of tuberculosis, hepatitis B, and other infections.
Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study
Authors: Yin Qiuyuan , Shi Guolin , Zhu Lei 
Published: October 2023

BackgroundSeveral recent studies speculated that the gut microbiota is associated with sensorineural hearing loss (SNHL) and proposed the concept of the gut–inner ear axis. However, the causal effect of gut microbiota on SNHL is still unknown. In this study, we performed a two-sample Mendelian randomization (MR) analysis to estimate the causal effect of gut microbiota on SNHL.MethodsGut microbiota data were obtained from the largest available genome-wide association study (n = 18,340) conducted by the MiBioGen consortium. The summary statistics of SNHL were obtained from the FinnGen consortium R8 release data (28,310 cases and 302,750 controls). The causal effects were estimated with inverse-variance weighted, MR-Egger, and weighted median. Reverse Mendelian randomization analysis was performed on the bacteria that were found to be associated with SNHL in forward Mendelian randomization analysis. We then performed sensitivity analyses, including Cochran's Q-test, MR-Egger intercept test, MR-PRESSO, cML-MA-BIC, and leave-one-out analysis, to detect heterogeneity and pleiotropy.ResultsThe inverse-variance weighted results suggested that Lachnospiraceae (UCG001) had a significant protective effect against SNHL (odds ratio = 0.85, 95% confidence interval: 0.78–0.93, P = 6.99 × 10−4). In addition, Intestinimonas (odds ratio = 0.89, 95% confidence interval: 0.82–0.97, P = 8.53 × 10−3) presented a suggestively protective effect on SNHL. Rikenellaceae (RC9gutgroup) (odds ratio = 1.08, 95% confidence interval: 1.02–1.15, P = 0.01) and Eubacterium (hallii group) (odds ratio = 1.12, 95% confidence interval: 1.00–1.24, P = 0.048) suggestively increase the risk of SNHL. The results of the reverse MR analysis showed that there is no significant causal effect of SNHL on the gut microbiota. No significant heterogeneity of instrumental variables or pleiotropy was detected.ConclusionThe evidence that the four genera mentioned above are associated with SNHL supports the hypothesis of a gut–inner ear axis. Our study provides microbial markers for the prevention and treatment of SNHL, and further studies are needed to explore the mechanisms of the gut microbiome–inner ear axis in health and diseases.
Temporal and spectral analyses of EEG microstate reveals neural effects of transcranial photobiomodulation on the resting brain
Authors: Truong Nghi Cong Dung , Wang Xinlong , Liu Hanli 
Published: October 2023

IntroductionThe quantification of electroencephalography (EEG) microstates is an effective method for analyzing synchronous neural firing and assessing the temporal dynamics of the resting state of the human brain. Transcranial photobiomodulation (tPBM) is a safe and effective modality to improve human cognition. However, it is unclear how prefrontal tPBM neuromodulates EEG microstates both temporally and spectrally.Methods64-channel EEG was recorded from 45 healthy subjects in both 8-min active and sham tPBM sessions, using a 1064-nm laser applied to the right forehead of the subjects. After EEG data preprocessing, time-domain EEG microstate analysis was performed to obtain four microstate classes for both tPBM and sham sessions throughout the pre-, during-, and post-stimulation periods, followed by extraction of the respective microstate parameters. Moreover, frequency-domain analysis was performed by combining multivariate empirical mode decomposition with the Hilbert-Huang transform.ResultsStatistical analyses revealed that tPBM resulted in (1) a significant increase in the occurrence of microstates A and D and a significant decrease in the contribution of microstate C, (2) a substantial increase in the transition probabilities between microstates A and D, and (3) a substantial increase in the alpha power of microstate D.DiscussionThese findings confirm the neurophysiological effects of tPBM on EEG microstates of the resting brain, particularly in class D, which represents brain activation across the frontal and parietal regions. This study helps to better understand tPBM-induced dynamic alterations in EEG microstates that may be linked to the tPBM mechanism of action for the enhancement of human cognition.
Measurement of body composition by deuterium oxide dilution technique and development of a predictive equation for body fat mass among severe neurologically impaired children
Authors: Sakamornchai Wirada , Dumrongwongsiri Oraporn , Phosuwattanakul Jeeraparn , Siwarom Sirinapa 
Published: October 2023

IntroductionNeurologically impaired (NI) children are at risk of malnutrition, which consequently impacts their health and quality of life. Accurate nutrition assessment is an important step in guiding appropriate nutrition support. Conventional anthropometric measurements among NI children have some limitations. Determining body composition requires more complex equipment, which is not routinely performed. This study was conducted to evaluate the association between anthropometric parameters and body composition assessed using the deuterium dilution technique (DDT) in NI children.MethodsA cross-sectional study enrolled severe NI children aged 1–20 years who received home enteral nutrition for at least 3 months. Weight, length, and 4-site skinfold thickness were measured. Body composition was determined using DDT following the International Atomic Energy Agency (IAEA) protocol.ResultsA total of 37 NI children (56.76% male, median age 7.2 years) were enrolled. The prevalence of underweight, stunting, and overweight were 22, 38, and 35%, respectively. Body composition analysis showed the mean (SD) of total body water (TBW) and fat mass (FM) were 10.52 (4.51) kg and 9.51 (6.04) kg, respectively. Multivariate GLM analysis showed that the factors associated with FM were age (β = 0.07 [0.05,0.08]; p &lt; 0.001), body mass index (BMI) (β = 0.82 [0.52, 1.12]; p &lt; 0.001), biceps skinfold thickness (BSF) (β = 0.49 [0.23,0.75]; p = 0.001), and subscapular skinfold thickness (SSF) (β = −0.24 [−0.46,0.03]; p = 0.030). A predictive equation for FM was constructed.ConclusionA high prevalence of malnutrition was found among severe NI children despite enteral nutrition support. Our findings showed that age, BMI, BSF, and SSF were associated with FM. The predictive equation of FM was proposed and needed to be further validated and applied to clinical practice.
The expression of Ki-67 and Glypican -3 in hepatocellular carcinoma was evaluated by comparing DWI and 18F-FDG PET/CT
Authors: Wang Xuedong , Li Lei , Wang Linjie , Chen Min 
Published: October 2023

ObjectiveThe value of DWI and 18F-FDG PET/CT in evaluating the expression of Ki-67 and GPC-3 in HCC was compared.Materials and methodsNinety-four patients with primary HCC confirmed by pathology were retrospectively divided into high- and low-Ki-67-expression groups and positive- and negative- GPC-3 groups. The ADC and SUVmax values of the lesions in both groups were measured. ROC curves were used to evaluate the identification efficiency of parameters with significant differences for each group of lesions, and AUCwas calculated. The combined ADC and SUVmax values were analyzed by binary logistic regression. The Delong test was used to compare the AUC values of the combined and single parameters. Pearson (in line with normal distribution) or Spearman (in line with abnormal distribution) correlation analysis was used to analyze the correlation.ResultsThe ADC value of the high-Ki-67-expression group was lower than that of the low-Ki-67-expression group (P&lt;0.05), and the SUVmax value of the high-expression group was higher than that of the low-expression group (P&lt;0.05). The ADC value of the positive-GPC-3 group was lower than that of the negative group (P&lt;0.0.tive group (P&lt;0.05). The combined ADC and SUVmax values in the GPC-3 group were better than those of a single parameter (P&lt;0.05). There was a strong negative correlation between the SUVmax value and ADC value in the Ki-67 group (R=-0.578, P&lt;0.001) and a weak negative correlation between the SUVmax value and ADC value in the GPC-3 group (R=-0.279, P=0.006). The SUVmax value was strongly positively correlated with the Ki-67 expression index (R=0.733, P&lt;0.001), while the ADC value was strongly negatively correlated with the Ki-67 expression index (R=-0.687, P&lt;0.001).ConclusionDWI and 18F-FDG PET/CT can be used to evaluate the expression of Ki-67 and GPC-3 in HCC, and there is a certain correlation between the ADC value and SUVmax. Combined DWI and 18F-FDG PET/CT is superior to a single technique in evaluating the expression of GPC-3 in HCC patients. However, the combined model did not benefit the Ki-67 group.