bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nastiness in Groups
Authors: Bauer Michal , Cahlíková Jana , Celik Katreniak Dagmara , Chytilová Julie , Cingl Lubomír , Želinský Tomáš 
Published: December 2023

Abstract
This paper provides evidence showing that people are more prone to engage in nasty behavior, malevolently causing financial harm to other people at own costs, when they make decisions in a group context rather than when making choices individually on their own. We establish this behavioral regularity in a series of large-scale experiments among university students, adolescents, and nationally representative samples of adults—more than ten thousand subjects in total. We test several potential mechanisms, and the results suggest that individual nasty inclinations are systematically more likely to affect behavior when decisions are made under the “cover” of a group, that is, in a group decision-context that creates a perception of diffused responsibility.
Characterization and catalytic investigation of fungal single-module nonribosomal peptide synthetase in terpene-amino acid meroterpenoid biosynthesis
Authors: Tseng Cheng-Chung , Chen Li-Xun , Lee Chi-Fang , Tu Zhijay , Lin Chun-Hung , Lin Hsiao-Ching 
Published: December 2023

Abstract

Hybrid natural products are compounds that originate from diverse biosynthetic pathways and undergo a conjugation process, which enables them to expand their chemical diversity and biological functionality. Terpene-amino acid meroterpenoids have garnered increasing attention in recent years, driven by the discovery of noteworthy examples such as the anthelmintic CJ-12662, the insecticidal paeciloxazine, and aculene A (1). In the biosynthesis of terpene-amino acid natural products, single-module nonribosomal peptide synthetases (NRPSs) have been identified to be involved in the esterification step, catalyzing the fusion of modified terpene and amino acid components. Despite prior investigations into these NRPSs through gene deletion or in vivo experiments, the enzymatic basis and mechanistic insights underlying this family of single-module NRPSs remain unclear. In this study, we performed biochemical characterization of AneB by in vitro characterization, molecular docking, and site-directed mutagenesis. The enzyme reaction analyses, performed with L-proline and daucane/nordaucane sesquiterpene substrates, revealed that AneB specifically esterifies the C10-OH of aculenes with L-proline. Notably, in contrast to ThmA in CJ-12662 biosynthesis, which exclusively recognizes oxygenated amorpha-4,11-diene sesquiterpenes for L-tryptophan transfer, AneB demonstrates broad substrate selectivity, including oxygenated amorpha-4,11-diene and 2-phenylethanol, resulting in the production of diverse unnatural prolyl compounds. Furthermore, site-directed mutagenesis experiments indicated the involvement of H794 and D798 in the esterification catalyzed by AneB. Lastly, domain swapping between AneB and ThmA unveiled that the A‒T domains of ThmA can be effectively harnessed by the C domain of AneB for L-tryptophan transfer, thus highlighting the potential of the C domain of AneB for generating various terpene-amino acid meroterpenoid derivatives.

One-Sentence Summary
The enzymatic basis and mechanistic insights into AneB, a single-module NRPS, highlight its capacity to generate various terpene-amino acid meroterpenoid derivatives.
How should we decide how to treat the child: harm versus best interests in cases of disagreement
Authors: Archard David , Cave Emma , Brierley Joe 
Published: December 2023

ABSTRACT
Where parents seek treatment for their young child that healthcare professionals cannot agree to, the High Court can determine what is in the child’s best interests. Some activists and academics seek change to impose threshold criteria that would bolster the decision-making rights of parents and reduce deference to clinicians and the courts. We defend the best interests standard against arguments that a higher threshold of ‘significant harm’ should apply. We do so from ethical, legal, and clinical perspectives. The matter is of significant moral and practical importance, especially in light of the divergence of academic opinion, the burgeoning number of cases coming before the courts and recent case law and statutory attempts to effect change. We begin by disputing ethical claims that a significant harm threshold is preferable to the best interests standard, and then we set out jurisprudential and practical arguments that demonstrate the imprudence of a significant harm threshold and defend the established yardstick of best interests.
The first ground-based detection of the 752 GHz water line in local ultraluminous infrared galaxies using APEX-SEPIA
Authors: Quinatoa Daysi , Yang Chentao , Ibar Edo , Humphreys Elizabeth , Aalto Susanne , Barcos-Muñoz Loreto , González-Alfonso Eduardo , Impellizzeri Violette , Jaffé Yara , Liu Lijie , Martín Sergio , Weiss Axel , Zhang Zhi-Yu 
Published: December 2023

ABSTRACT
We report the first ground-based detection of the water line p-H2O (211–202) at 752.033 GHz in three z &lt; 0.08 ultraluminous infrared galaxies (ULIRGs): IRAS 06035-7102, IRAS 17207-0014, and IRAS 09022-3615. Using the Atacama Pathfinder EXperiment (APEX), with its Swedish-ESO PI Instrument for APEX (SEPIA) band-9 receiver, we detect this H2O  line with overall signal-to-noise ratios of 8–10 in all three galaxies. Notably, this is the first detection of this line in IRAS 06035-7102. Our new APEX-measured fluxes, between 145 and 705 Jy km s−1, are compared with previous values taken from Herschel SPIRE FTS. We highlight the great capabilities of APEX for resolving the H2O  line profiles with high spectral resolutions while also improving by a factor of two the significance of the detection within moderate integration times. While exploring the correlation between the p-H2O(211–202) and the total infrared luminosity, our galaxies are found to follow the trend at the bright end of the local ULIRG’s distribution. The p-H2O(211–202) line spectra are compared to the mid-J CO and HCN spectra, and dust continuum previously observed with ALMA. In the complex interacting system IRAS 09022-3615, the profile of the water emission line is offset in velocity with respect to the ALMA CO(J = 4–3) emission. For IRAS 17207-0014 and IRAS 06035-7102, the profiles between the water line and the CO lines are spectroscopically aligned. This pilot study demonstrates the feasibility of directly conducting ground-based high-frequency observations of this key water line, opening the possibility of detailed follow-up campaigns to tackle its nature.
Neutrinos from pre-supernova in the framework of TQRPA method
Authors: Dzhioev A A , Yudin A V , Dunina-Barkovskaya N V , Vdovin A I 
Published: December 2023

ABSTRACT
We propose a new method for calculating spectra and luminosities for (anti)neutrinos produced in the pre-supernova environment by weak processes with hot nuclei. It is based on the thermal quasiparticle random phase approximation (TQRPA), which allows microscopic thermodynamically consistent calculations of the weak interaction response of nuclei at finite temperatures. For realistic representative pre-supernova conditions from the stellar evolution code MESA, we compute (anti)neutrino luminosities and spectra arising from neutral- and charged-current weak reactions with hot 56Fe and compare them with the contribution of thermal processes. We find that the TQRPA approach produces not only a higher total luminosity of electron neutrinos (mainly born in the electron capture reaction), compared to the standard technique based on the large-scale shell model (LSSM) weak interaction rates, but also a harder neutrino spectrum. Besides, applying the TQRPA and LSSM, we find that in the context of electron antineutrino generation, the neutral-current nuclear de-excitation (ND) process via neutrino-antineutrino pair emission is at least as important as the electron–positron pair annihilation process. We also show that flavour oscillations enhance the high-energy contribution of the ND process to the electron antineutrino flux. This could potentially be important for pre-supernova antineutrino registration by the Earth’s detectors.
Using transition density models to interpret experimental optical spectra of exciton-coupled cyanine (iCy3)2 dimer probes of local DNA conformations at or near functional protein binding sites
Authors: Heussman Dylan , Enkhbaatar Lulu , Sorour Mohammed I , Kistler Kurt A , von Hippel Peter H , Matsika Spiridoula , Marcus Andrew H 
Published: December 2023

Abstract
Exciton-coupled chromophore dimers are an emerging class of optical probes for studies of site-specific biomolecular interactions. Applying accurate theoretical models for the electrostatic coupling of a molecular dimer probe is a key step for simulating its optical properties and analyzing spectroscopic data. In this work, we compare experimental absorbance and circular dichroism (CD) spectra of ‘internally-labeled’ (iCy3)2 dimer probes inserted site-specifically into DNA fork constructs to theoretical calculations of the structure and geometry of these exciton-coupled dimers. We compare transition density models of varying levels of approximation to determine conformational parameters of the (iCy3)2 dimer-labeled DNA fork constructs. By applying an atomistically detailed transition charge (TQ) model, we can distinguish between dimer conformations in which the stacking and tilt angles between planar iCy3 monomers are varied. A major strength of this approach is that the local conformations of the (iCy3)2 dimer probes that we determined can be used to infer information about the structures of the DNA framework immediately surrounding the probes at various positions within the constructs, both deep in the duplex DNA sequences and at sites at or near the DNA fork junctions where protein complexes bind to discharge their biological functions.
Infrared imaging of magnetic octupole domains in non-collinear antiferromagnets
Authors: Wang Peng , Xia Wei , Shen Jinhui , Chen Yulong , Peng Wenzhi , Zhang Jiachen , Pan Haolin , Yu Xuhao , Liu Zheng , Gao Yang , Niu Qian , Xu Zhian , Yang Hongtao , Guo Yanfeng , Hou Dazhi 
Published: December 2023

ABSTRACT
Magnetic structure plays a pivotal role in the functionality of antiferromagnets (AFMs), which not only can be employed to encode digital data but also yields novel phenomena. Despite its growing significance, visualizing the antiferromagnetic domain structure remains a challenge, particularly for non-collinear AFMs. Currently, the observation of magnetic domains in non-collinear antiferromagnetic materials is feasible only in Mn3Sn, underscoring the limitations of existing techniques that necessitate distinct methods for in-plane and out-of-plane magnetic domain imaging. In this study, we present a versatile method for imaging the antiferromagnetic domain structure in a series of non-collinear antiferromagnetic materials by utilizing the anomalous Ettingshausen effect (AEE), which resolves both the magnetic octupole moments parallel and perpendicular to the sample surface. Temperature modulation due to AEE originating from different magnetic domains is measured by lock-in thermography, revealing distinct behaviors of octupole domains in different antiferromagnets. This work delivers an efficient technique for the visualization of magnetic domains in non-collinear AFMs, which enables comprehensive study of the magnetization process at the microscopic level and paves the way for potential advancements in applications.
Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation
Authors: Wu Zhanfeng , Liu Lei , Li Lei , Cao Xinran , Jia Wang , Liao Xiaodan , Zhao Zhongpu , Qi Hedong , Fan Guoqiang , Lu Huiqiang , Shu Chunying , Zhen Mingming , Wang Chunru , Bai Chunli 
Published: December 2023

ABSTRACT
Sleep deprivation (SD) is a severe public health threat that can cause systemic inflammation and nerve damage. Few effective and side-effect-free drugs are available to address SD. However, the bidirectional communications between the brain and gut provide new strategies for anti-SD therapeutics. Here we explored oral delivery of fullerene nano-antioxidants (FNAO) in the SD model to improve sleep by regulating abnormal intestinal barrier and systemic inflammation via the brain-gut axis. SD caused excessive reactive oxygen species (ROS) production and hyperactive inflammatory responses in the intestines of zebrafish and mouse models, leading to disturbed sleep patterns and reduced brain nerve activity. Of note, based on the property of the conjugated π bond of the C60 structure to absorb unpaired electrons, oral FNAO efficiently reduced the excessive ROS in the intestines, maintained redox homeostasis and intestinal barrier integrity, and ameliorated intestinal and systemic inflammation, resulting in superior sleep improvement. Our findings suggest that maintaining intestinal homeostasis may be a promising avenue for SD-related nerve injury therapy.
Estimating the Burden of Clinically Significant Staphylococcus aureus Infections and Predictors for Hospitalization for Skin and Soft Tissue Infections, Fulton County, Georgia, 2017
Authors: Phillip Katherine I , Webster Andrew S , Ray Susan M , Britton Amber , Swerdlow David , Fridkin Scott K 
Published: December 2023

Abstract

Background
Incidence estimates of Staphylococcus aureus infections rarely include the full spectrum of clinically relevant disease from both community and healthcare settings.

Methods
We conducted a prospective study capturing all S aureus infections in Fulton County, Georgia, during 2017. Medical records of patients with any incident infection (clinical cultures growing S aureus from any site, without prior positive culture in previous 14 days) were reviewed. Estimates of disease incidence were calculated using age-, race-, and sex-specific population denominators accounting for weighted sampling methods. Multivariable logistic regression models were used to identify risk factors for hospitalization among patients with skin and soft tissue infections (SSTIs).

Results
The overall incidence of clinically relevant S aureus infection was 405.7 cases per 100 000 people (standard error [SE], 5.62 [range, 400.1–411.3]). Overall incidence for those of Black race was 500.84 cases per 100 000 people (SE, 14.55), whereas White patients had overall incidence of 363.67 cases per 100 000 people (SE, 13.8). SSTIs were the most common infection (2351; 225.8 cases per 100 000 people [SE, 7.1]), and 30% required hospitalization. Among SSTIs, after adjusting for invasive disease, cellulitis, diabetes, and demographics, independent predictors of hospitalization included methicillin-resistant S aureus (adjusted odds ratio [aOR], 1.6 [95% confidence interval {CI}, 1.0–2.7]) and homelessness (aOR, 4.9 [95% CI, 1.1–22]).

Conclusions
The burden of clinically relevant S aureus infections is high, particularly among the Black population, and risks for hospitalization among SSTIs include isolate factors and factors related to patients’ vulnerability.
PSEUDO-ETIOLATION IN LIGHT proteins reduce greening by binding GLK transcription factors
Authors: Han Yuting , Li Fengfei , Wu Ying , Wang Dong , Luo Guangbao , Wang Xinning , Wang Xin , Kuang Hanhui , Larkin Robert M 
Published: December 2023

Abstract
Knocking out genes encoding proteins that downregulate the accumulation of pigments may lead to increases in crop quality and yield. PSEUDO-ETIOLATION IN LIGHT 1 (PEL1) downregulates the accumulation of carotenoids in carrot and chlorophyll in Arabidopsis and rice and may inhibit GOLDEN 2-LIKE (GLK) transcription factors. PEL1 belongs to a previously unstudied gene family found only in plants. We used CRISPR/Cas9 technology to knock out each member of the 4-member PEL gene family and both GLK genes in Arabidopsis. In pel mutants, chlorophyll levels were elevated in seedlings; after flowering, chloroplasts increased in size, and anthocyanin levels increased. Although the chlorophyll-deficient phenotype of glk1 glk2 was epistatic to pel1 pel2 pel3 pel4 in most of our experiments, glk1 glk2 was not epistatic to pel1 pel2 pel3 pel4 for the accumulation of anthocyanins in most of our experiments. The pel alleles attenuated growth, altered the accumulation of nutrients in seeds, disrupted an abscisic acid-inducible inhibition of seedling growth response that promotes drought tolerance, and affected the expression of genes associated with diverse biological functions, such as stress responses, cell wall metabolism hormone responses, signaling, growth, and the accumulation of phenylpropanoids and pigments. We found that PEL proteins specifically bind 6 transcription factors that influence the accumulation of anthocyanins, GLK2, and the carboxy termini of GLK1 and Arabidopsis thaliana myeloblastosis oncogene homolog 4 (AtMYB4). Our data indicate that the PEL proteins influence the accumulation of chlorophyll and many other processes, possibly by inhibiting GLK transcription factors and via other mechanisms, and that multiple mechanisms downregulate chlorophyll content.
The silver bullet that wasn’t: Rapid agronomic weed adaptations to glyphosate in North America
Authors: Landau Christopher , Bradley Kevin , Burns Erin , Flessner Michael , Gage Karla , Hager Aaron , Ikley Joseph , Jha Prashant , Jhala Amit , Johnson Paul O , Johnson William , Lancaster Sarah , Legleiter Travis , Lingenfelter Dwight , Loux Mark , Miller Eric , Norsworthy Jason , Owen Micheal , Nolte Scott , Sarangi Debalin , Sikkema Peter , Sprague Christy , VanGessel Mark , Werle Rodrigo , Young Bryan , Williams Martin M 
Published: December 2023

Abstract
The rapid adoption of glyphosate-resistant crops at the end of the 20th century caused a simplification of weed management that relied heavily on glyphosate for weed control. However, the effectiveness of glyphosate has diminished. A greater understanding of trends related to glyphosate use will shed new light on weed adaptation to a product that transformed global agriculture. Objectives were to (1) quantify the change in weed control efficacy from postemergence (POST) glyphosate use on troublesome weeds in corn and soybean and (2) determine the extent to which glyphosate preceded by a preemergence (PRE) improved the efficacy and consistency of weed control compared to glyphosate alone. Herbicide evaluation trials from 24 institutions across the United States of America and Canada from 1996 to 2021 were compiled into a single database. Two subsets were created; one with glyphosate applied POST, and the other with a PRE herbicide followed by glyphosate applied POST. Within each subset, mean and variance of control ratings for seven problem weed species were regressed over time for nine US states and one Canadian province. Mean control with POST glyphosate alone decreased over time while variability in control increased. Glyphosate preceded by a labeled PRE herbicide showed little change in mean control or variability in control over time. These results illustrate the rapid adaptation of agronomically important weed species to the paradigm-shifting product glyphosate. Including more diversity in weed management systems is essential to slowing weed adaptation and prolonging the usefulness of existing and future technologies.
News from Home: How Local Media Shapes Climate Change Attitudes
Authors: Andrews Talbot M , Kim Cana , Kim Jeong Hyun 
Published: December 2023

Abstract
Highlighting the local impacts of climate change has the potential to increase the public’s awareness of and engagement with climate change. However, information about local impacts is only effective when delivered by trusted sources such as copartisan political leaders. Is information about climate change conveyed by local media sources similarly beneficial? We argue that local media are well positioned to communicate the local implications of climate change, thereby enhancing the public’s risk perceptions of climate change and willingness to take climate action. We further hypothesize that climate coverage by local media, the media type that is more trusted across party lines, will have a significant influence on Republicans’ climate attitudes. Using the case of Louisiana, we first demonstrate that local and national newspapers cover climate change in substantially different ways, with local media more consistently focused on local impacts. Our survey experiment of Louisiana residents reveals that Republicans viewed the coverage of a hurricane in the region more positively when it came from a local newspaper rather than a national newspaper. Furthermore, local newspapers’ climate coverage increased Republicans’ willingness to take action to mitigate climate change. These results provide insights into the effective communication of climate change to the public and the role of local media in mitigating partisan polarization.
Impurity and hybridization effects on the symmetry classification and magnetic response function of a two-band superconductor with interband pairing order
Authors: Aghamohammadi Renani F , Yavari H 
Published: December 2023

Abstract
The effects of hybridization and impurity (magnetic and nonmagnetic) potentials on the pairing symmetries and magnetic response of a two-band superconductor with an equal-time s-wave interband pairing order parameter in the framework of Green’s function technique are investigated theoretically. First, the effects of spin-independent and spin-dependent hybridization on the generation of even- or odd-frequency Cooper pairs which determines the symmetry classification and the response of the superconductor are studied. Next, the impurity effect on creating different symmetry classes and the kernel response function of a two-band superconductor are discussed. By separating the contributions of even- and odd-frequency pairing to the Meissner kernel, it is shown that the competition between these two terms determines the total Meissner effect of the superconductor. For a two-band spin-singlet superconductor, nonmagnetic impurity scatterings do not change transition temperature according to Anderson’s theorem, while both intra- and interband magnetic impurity scattering cause superconducting transition temperature suppression with the rate following the Abrikosov–Gor’kov theory. For spin-triplet pairing, interband magnetic scattering has no impact on pair breaking, whereas intraband magnetic scattering acts as a pair breaker and suppresses the transition temperature in the Born limit. In this case, the odd-frequency superconducting pairs can be induced in the simultaneous presence of both intra- and interband magnetic impurities. Thus, by controlling the concentration of magnetic impurities, it is possible to engineer triplet-pairing odd-frequency superconductors with a total diamagnetic Meissner response which stabilizes the superconducting state. This technique opens up an avenue for designing stable odd-frequency superconductors.