bluuebunny/crossref_metadata_2025_split huggingface dataset:
TEM characterization of La/B4C multilayer systems by the geometric phase method
Authors: Häussler D. , Spiecker E. , Yang S. , Jäger W. , Störmer M. , Bormann R. , Zwicker G. 
Published: August 2005

AbstractNew La/B4C multilayer systems with layer thicknesses in the nanometer range have been deposited onto structured silicon (001) surfaces by magnetron sputtering and have been characterized by transmission electron microscopy (TEM). By applying a geometric phase method which has been originally developed for measuring displacement fields from high‐resolution TEM images, we demonstrate that the structural perfection of multilayers, especially their local layer periods and local layer orientations, can be analyzed with high sensitivity from bright‐field TEM images of cross‐section specimens. The determination of these structure parameters is relevant for the assessment of the reflectivity properties of such multilayer systems in advanced X‐ray optical components. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effective and practical risk management options for computerised system validation
Authors: McDowall R.D. 
Published: August 2005

AbstractRisk management and risk assessment for computerised systems validation is a key regulatory issue following the Food and Drug Administration's (FDA) reassessment of the 21 Code of Federal Regulation (CFR) Part 11 regulations (Electronic Records and Electronic Signatures final rule). This paper reviews the GXP (i.e. Good Laboratory Practice (GLP), Good Clinical Practice (GCP) and Good Manufacturing Practice (GMP)) regulatory requirements and associated guidance documents and then focuses on the International Standards Organisation (ISO) 14971 risk management process and vocabulary for an overall risk management framework.Several risk analysis methodologies are presented and assessed for their applicability for computerised system validation (CSV). The conclusion is that one methodology does not fit all situations and the prudent professional should select the best methodology applicable for the problem at hand. Finally, an overall risk management process flow for CSV is presented and discussed based on two questions: ‘Do I need to validate the system?’ and if so, ‘How much work do I need to do?’ A single integrated document is presented as an alternative to a full V‐model for the validation of lower risk computer systems. Copyright © 2005 John Wiley & Sons, Ltd.
What's New?
Authors: Hattemer‐Apostel Rita , Broughton Harold Steven 
Published: August 2005

AbstractThe What's New? section in the Quality Assurance Journal aims to draw attention to items of importance to QA professionals. There is usually a three‐month interval between final submission of manuscripts and distribution of the journal. For this issue, the entries in the What's New? section arise from the period of 1 March 2005 to 31 May 2005. If you feel that there is any other new information that should be brought to the attention of readers, please let us know by e‐mailing rha@verdandi.ch. Copyright © 2005 John Wiley & Sons, Ltd.
An adaptive quality‐of‐service network selection mechanism for heterogeneous mobile networks
Authors: Song Qingyang , Jamalipour Abbas 
Published: August 2005

AbstractThe success of broadband service has attracted more people to surf internet with the demand of high mobility and high bandwidth. The ongoing wireless local area network (WLAN) standardization and development activities allow WLAN to provide high data rate in unlicensed spectrum. It motivates cellular network operators to adopt WLAN as a complement to cellular 3G systems in hot spot areas. Consequently, it is imperative to develop a network selection technique to assure quality‐of‐service (QoS) for the integrated cellular/WLAN system. In this paper, an optimization scheme for mobile users to select a network in an integrated WLAN and universal mobile telecommunication system (UMTS) system is proposed. In order to provide users a prospect of being always best connected, analytic hierarchy process (AHP) and grey relational analysis (GRA) techniques are integrated to make decision. The former defines selection criteria and the latter evaluates network alternatives. The network selection module is built at the link layer, and collects the time‐varying QoS information through cross‐layer message signaling. Simulations conducted in a heterogeneous system with UMTS and WLAN show that the proposed network selection technique can successfully satisfy QoS requirements for a variety of applications through a fair decision on the optimum network for mobile users at any time. Copyright © 2005 John Wiley & Sons, Ltd.
Candida albicans SOU1 encodes a sorbose reductase required for L‐sorbose utilization
Authors: Greenberg Jay R. , Price Neil P. , Oliver Richard P. , Sherman Fred , Rustchenko Elena 
Published: August 2005

AbstractPrevious work in our laboratory showed that L‐sorbose utilization in Candida albicans is subject to a novel form of regulation which involves a reversible increase or decrease in the copy number of chromosome 5. Furthermore, the structural gene SOU1 is required for L‐sorbose utilization and encodes a member of the short chain dehydrogenase family. However, the precise function of SOU1 was not known and neither was the pathway for L‐sorbose utilization. We have now expressed SOU1 at a high level from a replicative plasmid having a constitutive ADH1 promoter and purified a version of Sou1p tagged with the FLAG epitope at the N‐terminus. Sou1FLAGNp has a sorbose reductase activity which utilizes NADPH as a co‐factor and converts L‐sorbose to D‐sorbitol. It can also less efficiently utilize fructose as a substrate with NADPH as a co‐factor, converting fructose to mannitol. In agreement with prediction, the purified enzyme has a subunit molecular weight of 31 kDa and a pI of about 4.8. It probably consists of four identical subunits and has a pH optimum of 6.2. The L‐sorbose utilization pathway in C. albicans probably converts L‐sorbose to fructose‐6‐phosphate via D‐sorbitol as an intermediate. The first step is catalysed by Sou1p. We also found that C. albicans extracts have a D‐sorbitol‐6‐phosphate dehydrogenase activity, not encoded by SOU1, which utilizes NADP as a co‐factor. This activity has not been described previously in yeasts and may be involved in the conversion of phosphorylated D‐sorbitol to fructose‐6‐phosphate or glucose‐6‐phosphate. Copyright © 2005 John Wiley & Sons, Ltd.
Characterization of thiol‐specific antioxidant 1 (TSA1) of Candida albicans
Authors: Shin Duck Hyang , Jung Saem , Park So Jeong , Kim Yeo Jung , Ahn Jung Min , Kim Wankee , Choi Wonja 
Published: August 2005

AbstractWe previously identified several proteins that are differentially expressed in pathogenic hyphae by comparing protein profiles of yeast and hyphae of Candida albicans. One of these, thiol‐specific antioxidant 1 (TSA1), attracted our attention because it may play some roles in surviving an unfavourable oxidative environment created by host cells. Two alleles of the C. albicans TSA1 (CaTSA1) gene are located in opposite orientation on the same chromosome. Using PCR‐directed disruption cassettes and URA‐Blaster, a series of deletion mutants that lack one to four copies were constructed to examine the functions of CaTSA1. Northern and Western analyses showed that both the transcript and protein products of CaTSA1 decreased proportionally to the disrupted copy number and were completely absent in the null mutant, indicating that all four TSA1 copies are equally functional at the transcriptional level. Intracellular H2O2 increased by an order of magnitude in deletion mutants lacking three to four copies, suggesting that CaTsa1p is not a redundant H2O2 scavenger. CaTsa1p was indispensable for yeast‐to‐hyphal transition when C. albicans was cultured under oxidative stress. The level of its oxidized form increased ∼five‐fold in hyphal cells, whereas that of the reduced form increased two‐fold compared to yeast cells. The ratio of oxidized to reduced form was increased three‐fold in hyphal cells. This overall increase was found to be controlled at the post‐transcriptional level. Interestingly, CaTsa1p is translocated to the nucleus of hyphal cells. These findings may be of biological significance for differentiation and pathogenicity. Copyright © 2005 John Wiley & Sons, Ltd.
Characterization of GPI14/YJR013w mutation that induces the cell wall integrity signalling pathway and results in increased protein production in Saccharomyces cerevisiae
Authors: Davydenko Svetlana G. , Feng DeJiang , Jäntti Jussi , Keränen Sirkka 
Published: August 2005

AbstractWe report here identification and characterization of a mutation in the GPI14 gene, the yeast homologue of the mammalian PIG‐M that functions in the synthesis of the GPI moiety anchoring proteins to the plasma membrane. We show that the first putative transmembrane domain of Gpi14p is not essential for its function. Downregulation of GPI14 expression/reduced protein function due to an amino terminal deletion resulted in increased transcription and production of an endogenous and a heterologous secreted protein expressed from HSP150 and ADH1 promoter, respectively. In these cells, unfolded protein response was induced but was not responsible for the enhanced production of these proteins. A cell wall defect in the gpi14 mutant cells was suggested by cell aggregation phenotype, increased sensitivity to Calcofluor white, an increased release of Gas1p and total protein into the culture medium. In the gpi14 mutant cells, transcription of RLM1, a transcription factor participating in the cell wall integrity signalling pathway, was increased, and deletion of RLM1 resulted in a synthetic lethal phenotype with the gpi14 mutation. These results suggest that partial inactivation of Gpi14p causes defects in the cell wall structure and suggest that compromised GPI anchor synthesis results in enhanced protein production via the cell wall integrity signalling pathway. Copyright © 2005 John Wiley & Sons, Ltd.
Low‐Dimensional Structural Units in Amine‐Templated Uranyl Oxoselenates(VI): Synthesis and Crystal Structures of [C3H12N2][(UO2)(SeO4)2(H2O)2](H2O), [C5H16N2]2[(UO2)(SeO4)2(H2O)](NO3)2, [C4H12N][(UO2)(SeO4)(NO3)], and [C4H14N2][(UO2)(SeO4)2(H2O)]
Authors: Krivovichev Sergey V. , Kahlenberg Volker 
Published: August 2005

AbstractThe crystals of four amine‐templated uranyl oxoselenates(VI), [C3H12N2][(UO2)(SeO4)2(H2O)2](H2O) (1), [C5H16N2]2[(UO2)(SeO4)2(H2O)](NO3)2 (2), [C4H12N][(UO2)(SeO4)(NO3)] (3), and [C4H14N2][(UO2)(SeO4)2(H2O)] (4) were prepared by evaporation from aqueous solution of uranyl nitrate, selenic acid and the respective amine. The crystal structures of all four compounds have been solved by direct methods from X‐ray diffraction data. The structure of 1 (triclinic, ${\rm P}{\bar 1}$, a = 7.5611(16), b = 7.7650(17), c = 12.925(3) Å, α = 94.605(18), β = 94.405(17), γ = 96.470(17)°, V = 748.8(3) Å3, R1 = 0.029 for 2769 unique observed reflections) is based upon 0D‐units of the composition [(UO2)2(SeO4)4(H2O)4]4−. These discrete units are composed from two pentagonal [UO7]8− bipyramids linked via [SeO4]2− tetrahedra and are unknown in structural chemistry of uranium so far. The structure of 2 (monoclinic, C2/c, a = 28.916(5), b = 8.0836(10), c = 11.9856(16) Å, β = 110.909(11)°, V = 2617.1(6) Å3, R1 = 0.035 for 2578 unique observed reflections) contains [(UO2)(SeO4)2(H2O)]2− chains of corner‐sharing pentagonal [UO7]8− bipyramids and [SeO4]2− tetrahedra. The chains run parallel to the c axis and are arranged into layers parallel to (100). In the structure of 3 (monoclinic, C2/m, a = 21.244(5), b = 7.1092(11), c = 8.6581(18) Å, β = 97.693(17)°, V = 1295.8(4) Å3, R1 = 0.027 for 1386 unique observed reflections), pentagonal [UO7]8− bipyramids share corners with three [SeO4]2− tetrahedra each and an edge with a [NO3]− anion to form [(UO2)(SeO4)(NO3)]− chains parallel to the b axis. In the structure of 4 (triclinic, ${\rm P}{\bar 1}$, a = 6.853(2), b = 10.537(3), c = 10.574(3) Å, α = 99.62(3), β = 94.45(3), γ = 100.52(3)°, V = 735.6(4) Å3, R1 = 0.045 for 2713 unique observed reflections), one symmetrically independent pentagonal [UO7]8− bipyramid shares corners with four [SeO4]2− tetrahedra to form the [(UO2)(SeO4)2(H2O)]2− chains parallel to the a axis. A comparison to related uranyl compounds is given.
Synthesis and Structure of a New Vanadium(IV)‐Cadmium(II) Compound with the Nitrilotriacetate Ligand: {(NH4)2[(VIVO)2(μ2‐O)(nta)2Cd(H2O)2]·H2O}n
Authors: Zhang Quan‐Zheng , Lu Can‐Zhong , Yang Wen‐Bin 
Published: August 2005

AbstractA polymeric VIV‐Cd compound, {(NH4)2[(VIVO)2(μ2‐O)(nta)2Cd(H2O)2]·H2O}n (H3nta = nitrilotriacetic acid), has been prepared and characterized by single‐crystal X‐ray diffraction. The compound crystallizes in the monoclinic space group C2/c with a = 17.3760(2) Å, b = 8.0488(1) Å, c = 17.3380(2) Å, β = 107.9690(10)°, V = 2306.55(5) Å3, Z = 4, and R1 = 0.0303 for 1958 observed reflections. The structure exhibits a heterometallic three‐dimensional network formed by polymeric [(VIVO)2(μ2‐O)(nta)2Cd(H2O)2]2− anions.
Amine‐Templated Uranyl Selenates with Layered Structures. I Structural Diversity of Sheets with a U:Se ratio of 1:2
Authors: Krivovichev Sergey V. , Kahlenberg Volker , Tananaev Ivan G. , Myasoedov Boris F. 
Published: August 2005

AbstractCrystals of four amine‐templated layered uranyl selenates, [C2H10N2][(UO2)(SeO4)2(H2O)](H2O) (1), [CH6N3]2[(UO2)(SeO4)2(H2O)](H2O)1.5 (2), [C4H12N]2[(UO2)(SeO4)2(H2O)] (3), and [CH6N3]3[(UO2)2(SeO4)2(H(SeO4)2)](H2O)2 (4) were prepared by evaporation from aqueous solution of uranyl nitrate, selenic acid and the respective amine. The structures of all four compounds have been solved by direct methods. The structures of 1 (monoclinic, C2/c, a = 11.787(2), b = 7.7007(10), c = 16.600(3) Å, β = 102.016(14)°, V = 1473.7(4) Å3, R1 = 0.037 for 1743 unique observed reflections), 2 (monoclinic, C2/c, a = 37.314(4), b = 7.1771(6), c = 13.2054(14) Å, β = 109.267(8)°, V = 3338.4(6) Å3, R1 = 0.088 for 3005 unique observed reflections) and 3 (monoclinic, C2/c, a = 27.212(10), b = 7.372(3), c = 23.113(7) Å, β = 117.75(2)°, V = 4103(3) Å3, R1 = 0.073 for 2111 unique observed reflections) are based on sheets of the composition [(UO2)(SeO4)2(H2O)]2− consisting of pentagonal [UO7]8− pentagonal bipyramids linked via [SeO4]2− tetrahedra. The sheets have the same chemical composition but different topologies. The structure of 4 (orthorhombic, P212121, a = 10.7261(9), b = 13.918(2), c = 18.321(2) Å, V = 2735.1(5) Å3, R1 = 0.050 for 5683 unique observed reflections) contains [(UO2)2(SeO4)2(H(SeO4)2)]3− sheets parallel to (001). In all four structures, the layers are connected via protonated amine and H2O molecules.
Complexation of 1,4‐Bis(phenylthio)butane on Mercury(II) Salts: Formation of Extended 2D Coordination Polymers
Authors: Peindy Harmel N. , Guyon Fabrice , Knorr Michael , Strohmann Carsten 
Published: August 2005

AbstractTwo novel two‐dimensional (2D) coordination polymers of stoichiometry [{PhS(CH2)4SPh}Hg2X4]n (X = Cl, 2a; X = Br, 2b) have been prepared by treatment of HgX2 with PhS(CH2)4SPh 1, acting as bridging dithioether ligand. The extended 2D structures result from bridging coordination of 1 between two mercury atoms and intermolecular Hg–X interactions, thus linking the HgX2 units in two dimensions. As established for 2a,b by single‐crystal X‐ray diffraction, the coordination around the Hg centers in both isomorphous compounds (monoclinic, space group P21/c) is distorted tetrahedral, with quite short Hg‐thioether bonds of 2.4780(19) (2a) and 2.499(3) Å (2b), respectively.
Darstellung und Kristallstruktur von Cadmiumazid Cd(N3)2
Authors: Karau Friedrich , Schnick Wolfgang 
Published: August 2005

AbstractPreparation and Crystal Structure of Cadmium Azide Cd(N3)2Solvent free, binary cadmium azide was synthesized by the reaction of cadmium carbonate and a 24 weight% solution of HN3 in water. Cadmium azide is a colorless, crystalline powder which is highly sensitive to percussion and heat. Caution, the manipulation of Cd(N3)2 is very dangerous!The crystal structure was solved by single‐crystal methods and the phase purity was verified by a Rietveld refinement (Cd(N3)2, Pbca, no. 61; a = 7.820(2), b = 6.440(2), c = 16.073(3) Å; Z = 8, 1174 independent reflections, 64 parameters, R1 = 0.022). Cadmium azide crystallizes in a new structure type. In the crystal there are edge‐sharing Cd2(N3)10 double octahedrons which are further connected to other units by azide bridges. Vibrational spectroscopic investigations (Raman an IR) are discussed with respect to the crystal structure data.
[{ReN(PMe2Ph)3}{ReO3N}]2 – Structural Evidence for the Nitridotrioxorhenate(VII) Anion, [ReO3N]2−
Authors: Braband Henrik , Yegen Eda , Oehlke Elisabeth , Abram Ulrich 
Published: August 2005

AbstractAir‐stable, orange‐red single crystals of [{ReN(PMe2Ph)3}{ReO3N}]2 are formed when mer‐[ReNCl2(PMe2Ph)3] reacts with strong bases in MeOH. The resulting centrosymmetric tetranuclear complex contains each two {ReN(PMe2Ph)3}2+ and {ReO3N}2− building blocks. They are connected by two oxygen and two nitrogen atoms giving an almost planar {Re4O2N2} ring. The Re–N–Re bridges are only slightly bent (175.2(2)°), while the Re–O–Re angles are 160.9(1)°. The coordination environment of the rhenium atom in the nitridotrioxorhenate(VII) anion is a slightly distorted tetrahedron with O–Re–O and O–Re–N angles between 108.7(1)° and 111.3(1)°.
Selenious Acid as a Ligand: Molecular and Crystal Structure of [Co(H2O)2Cl2(H2SeO3)2]
Authors: Hamida Makram Ben , Wickleder Mathias S. 
Published: August 2005

Abstract[Co(H2O)2Cl2(H2SeO3)2] (monoclinic, P21/c, Z = 2, a = 519.82(5), b = 1462.6(1), c = 643.09(7) pm, β = 92.51(1)°, Rall = 0.0583) was obtained from CoCl2 and H2SeO3 as purple plate–shaped single crystals. In the compound, the Co2+ ions are octahedrally coordinated by two Cl− ions, two H2O molecules, and two monodentate H2SeO3 molecules, leading to neutral complexes [Co(H2O)2Cl2(H2SeO3)2]. They are connected by hydrogen bonds involving both chlorine and oxygen atoms as acceptor atoms.
Synthese, Charakterisierung und Struktur des donorstabilisierten monomeren [PS3]− – Anions (Monometatrithiophosphates)
Authors: Dimitrov Anton , Hartwich Irmgard , Ziemer Burkhard , Heidemann Detlef , Meisel Manfred 
Published: August 2005

AbstractSynthesis, Characterization, and Structure of the Donor‐stabilized Monomeric [PS3]− Anion (Monometatrithiophosphate)The reaction between H2S and some σ4λ5‐derivatives of the monometa‐dithioxaphosphoric acid, [Py→PS2X] (Py = pyridine, X = Cl, NR2), at low temperature in propionitrile as a solvent leads to the formation of the corresponding ammonium salts with the new anion [Py→PS3]− (1). The single crystal structure determinations of three compounds 1a‐1c bearing the new title anion 1 reveal the existence of considerably short distances between the nitrogen of the cation and the sulphur atoms of the anion connected by a cationic proton in all cases. These hydrogen bond contacts fall below the sum of van der Waals radii of nitrogen and sulphur and are crucial for the stabilization of 1 in the crystals which is an electronical support in nature. If acidic hydrogen atoms are not present in the cations of the salts as in the case of tetraphenylarsonium as a counter cation a stabilisation of the new anion 1 does not occur. In this case, even from pyridine solutions, only the salt with the well known dimeric anion [PS3]22− crystallizes.
Synthesis, Characterization and Crystal Structures of new Palladium(II) Complexes and the first Platinum(III) Complex Containing ATT (ATT = 6‐Aza‐2‐thiothymine)
Authors: Ghassemzadeh Mitra , Heravi Majid M. , Neumüller Bernhard 
Published: August 2005

AbstractTreatment of the ligand 6‐aza‐2‐thiothymine (ATT, HL, 1) with palladium chloride in methanol forms the ionic complex [(HL)4Pd]Cl2·8MeOH (2), while its reaction with palladium iodide in same solvent produces the neutral complex trans‐[(HL)2PdI2]·2MeOH (3) in high yields. The reaction of 1 with Na2[PdCl4] in the presence of sodium acetate in a molar ratio of 2:1:2 and with platinum(II) chloride in presence of sodium acetate led to the dimer tetranuclear complexes [(L4Pd2)NaCl]2·8MeOH (4) and [L4Pt2Cl2]·6MeOH·H2O (5). The latter is the first PtIII complex of the ligand. All complexes were characterized by elemental analyses and IR spectroscopy and the crystal structures of 2, 3, 4 and 5 are determined by single‐crystal X‐ray diffraction. Crystal data for 2 at −80 °C: triclinic space group ${\rm P}{\bar 1}$, a = 1006.6(1), b = 1006.9(1), c = 1158.1(1) pm, α = 85.20(1)°, β = 83.84(1)°, γ = 88.91(1)°, Z = 1, R1 = 0.0278; for 3 at −80 °C: triclinic space group ${\rm P}{\bar 1}$, a = 490.5(1), b = 977.2(2), c = 1116.8(2) pm, α = 90.26(1)°, β = 102.33(1)°, γ = 96.08(1)°, Z = 1, R1 = 0.0394; for 4 at −80 °C: orthorhombic space group Ccca, a = 1791.7(2), b = 1874.1(2), c = 2044.0(1) pm, Z = 4, R1 = 0.0341 and for 5 at −80 °C: monoclinic space group P21/c, a = 1464.3(1), b = 2003.7(1), c = 1368.5(1) pm, β = 95.66(1)°, Z = 4, R1 = 0.0429.
Selten‐Erd‐Metall‐Koordinationspolymere: Synthesen und Kristallstrukturen von drei neuen Glutaraten, [Pr2(Glu)3(H2O)4] · 10,5H2O, [Pr(Glu)(H2O)2]Cl und [Er(Glu)(GluH)(H2O)2]
Authors: Bromant Claudia , Nika Wassiliki , Pantenburg Ingo , Meyer Gerd 
Published: August 2005

AbstractRare‐Earth‐Metal Coordination Polymers: Syntheses and Crystal Structures of Three New Glutarates, [Pr2(Glu)3(H2O)4] · 10.5H2O, [Pr(Glu)(H2O)2]Cl, and [Er(Glu)(GluH)(H2O)2]The new rare‐earth dicarboxylates [Pr2(Glu)3(H2O)4] · 10.5H2O (1), [Pr(Glu)(H2O)2]Cl (2) and [Er(Glu)(GluH)(H2O)2] (3) were obtained from the reactions of glutaric acid with PrCl3·6H2O and Er(OH)3, respectively. The crystal structures were determined by single‐crystal X‐ray diffraction. [Pr2(Glu)3(H2O)4] · 10,5H2O crystallizes in the orthorhombic space group Pnma (no. 62) with a = 871.7(4), b = 3105.0(9), c = 1308.3(9) pm and Z = 4. The crystals of [Pr(Glu)(H2O)2]Cl are monoclinic (I2/a; no. 15) with a = 786.2(1), b = 1527.6(2) c = 801.2(1) pm, β = 99.78(1)° and Z = 4. [Er(Glu)(GluH)(H2O)2] crystallizes in the monoclinic space group P21/a (no. 14) with lattice parameters of a = 882.4(1), b = 1375.3(2), c = 1267.4(2) pm, β = 107.13(1)° and Z = 4. The rare‐earth cations have the coordination numbers 10 (1), 8 + 1 (2) and 9 (3). The individual polyhedra are connected to chains and further to sheets in 1 and 2 and to double chains in 3. Only in the water‐rich compound 1 there are channels that contain crystal water molecules. It, therefore, has a considerably lower density than 2 and 3.
A New Copper(II) Complex with the N,N′‐Tetra(antipyryl‐4‐methyl)‐1,2‐ethanediamine (TAMEN) Ligand: [Cu(TAMEN)](ClO4)2·H2O·DMF
Authors: Tudose Ramona , Pantenburg Ingo , Mosoarca Elena Maria , Meyer Gerd , Costişor Otilia 
Published: August 2005

AbstractThe synthesis of the Mannich base N,N′‐tetra(antipyryl‐4‐methyl)‐1,2‐ethanediamine (TAMEN) (1), its crystal structure as well as the synthesis and the crystal structure of the copper complex [Cu(TAMEN)](ClO4)2·H2O·DMF (2) are reported. C50H56N10O4·2C2H5OH (TAMEN·2EtOH) crystallizes with triclinic symmetry, space group $P{\bar 1}$, lattice parameters: a = 877.3(1), b = 1078.1(1), c = 1433.3(2) pm, α = 71.93(1), β = 82.16(1), γ = 84.54(1)° and Z = 1. The copper complex [Cu(TAMEN)](ClO4)2·H2O·DMF also crystallizes with triclinic symmetry, space group $P{\bar 1}$, lattice parameters: a = 1279.2(2), b = 1485.6(2), c = 1513.6(2) pm, α = 98.04(1), β = 101.24(1), γ = 94.66(1)° and Z = 2. The copper(II) atom is six‐coordinate with an elongated pseudo‐octahedral geometry due to a strong Jahn‐Teller effect.