bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Walker’s paradise ain’t a driver’s hell: Evaluating the causal effect of temporary road pedestrianization on traffic conditions of surrounding roads
Authors: Parady Giancarlos , Chikaraishi Makoto , Oyama Yuki 
Published: December 2023

Abstract

This study uses a natural experiment approach to evaluate the causal effect of three regular road pedestrianization schemes in Central Tokyo on traffic conditions in surrounding areas. Cross-sectional traffic flow data collected by the Metropolitan Police Department via traffic counters was used as the dependent variable and causal effect evaluation was done via a difference-in-differences (DID) approach, where the temporal pedestrianization of a street was used as the treatment of interest. We take advantage of (1) the variability in pedestrianization execution days and (2) the seasonal variability in pedestrianization time periods, to define the natural experiments. Furthermore, three different buffer areas of 500m, 750m and 1000m were used to evaluate the sensitivity of effect estimates to the definition of the impact area. Results suggest that irrespective of buffer size, the impact of temporal road pedestrianization on cross-sectional traffic flow of surrounding roads is negligible. Point estimates of treatment effect magnitudes across all models are small (ranging from − 4.8–6.9%) and estimated with high degrees of uncertainty, with most confidence intervals including zero. As such, results do not show evidence of practically important increases in traffic flow in the surrounding areas of pedestrianized roads and point to some degree of “traffic evaporation” likely resulting from drivers’ behavioral adaptation.
Hydropriming improves seed germination in horned melon (Cucumis metuliferus E. Mey. Ex Naudin) landraces
Authors: Mutetwa Moses , Chaibva Paul , Chagonda Ignatius , Makuvaro Veronica , Mtaita Taurira , Ngezimana Wonder , Masaka Johnson , Manjeru Pepukai 
Published: December 2023

The global popularity of horned melon highlights the need of sound crop establishment processes, since uniform and quick seed germination has a substantial influence on crop yield and quality. Using a Completely Randomised Design (CRD) with a factorial structure, the effects of hydro priming durations (0, 8, 16, 24, 32, and 40 h) on seeds of two horned melon landrace (L1&L2) were investigated. Hydro priming had significant (P>0.05) influence on several germination indices (germination percentage, relativized percentage, mean germination rate, germination index, synchronization, duration to 50 % germination, mean daily germination, peak value, and germination value). Among the germination indicators tested, landrace (L2) exhibited a considerably stronger germination response than L1. The findings also reveal a curvilinear relationship between priming length and germination percentage, with 24 hours being greatest proportionately. The mean germination rate, germination index, mean daily germination, peak value of germination, and germination value all rose as the hydro priming duration increased. Primed seeds germinated more quickly than unprimed ones. With increasing priming duration, the synchronization index fell linearly. The interaction between landraces and hydro priming was not significant (P>0.05) for final seed germinated, relativized germination, and synchronization indices, but it had a significant impact on all other indices. Because the efficacy of hydro priming tends to lessen with extended soaking, we recommend using it for a maximum of 32 hours. Future study should concentrate on alternative priming chemicals and the applicability of various priming solutions for various agroecosystems
Chemical composition of summer truffle (Tuber aestivum Vittad.) from Bosnia and Herzegovina
Authors: Ljubojević Srđan , Vasilišin Ladislav , Vučić Goran , Velemir Ana 
Published: December 2023

Ascocarps of summer truffle (Tuber aestivum Vittad.) were found in natural oak and beech forests on calcareous soils, at altitude of 840–850 m, near the town of Šipovo in Bosnia and Herzegovina (B&H), with the help of trained dogs.
Until now, no one in B&H has researched the chemical composition of summer truffle. The aim of the work is to analyze nutritional value, elemental composition, and the assortment of fatty acids in the freshly collected ascocarps and to compare achieved results with the results from the literature related to the summer truffle ascocarps found in some other locations, then with the ascomata of other species of truffles, and with the fruiting bodies of some above-ground edible mushrooms.
Chemical analysis showed that Tuber aestivum contains about 75.5 % water and about 25.5 % dry matter. The most common group of compounds were carbohydrates, followed by proteins, while the mineral component and fats were much less presented. Among analyzed elements, the most prevalent was potassium with an average concentration of 26,409 mg/kgDW and the least represented was lead with an average concentration of 0.45 mg/kgDW. The main part of the mineral spectrum consisted of three elements: K, P and Ca, with a share of 95.3 %. In ascocarps of summer truffle, 24 fatty acids were detected, of which 13 were saturated and 11 unsaturated. The ratio of saturated to unsaturated fatty acids was 58.34 % to 41.66 %. The most common among saturated fatty acids was palmitic with a share of 25.89 %, while the most common unsaturated fatty acid was elaidic with a share of 28.17 %. No ingredients have been found in the fruiting bodies that would make them unfit for human consumption in any way
Prevalence of Moderate to Severe Depressive Symptoms among Adults in the
UAE: A Cross-sectional Study
Authors: Salman Salman Mohamad , Alkhdour Abdel Rahman , Alsyouti Tala , Haddad Mohammad , Sharbatti Shatha Al 
Published: December 2023

Objective::
The objectives of the study were to assess the prevalence of moderate to severe depressive symptoms among adults aged 18 years or older, assess
the relationship between the severity of depression and selected socio-demographic, psycho-social, lifestyle, and health-related factors, and identify
the determinants of moderate-to-severe depressive symptoms in the adult population of 18 years and older in the United Arab Emirates (UAE).

Methods::
This was a cross-sectional study conducted in the United Arab Emirates that targeted residents above 18 years of age. A research questionnaire was
developed and approved by three specialists in the field, along with the Patient Health Questionnaire-9 (PHQ9). The Chi-square test was used to
assess the association between variables, and multiple logistic regression analysis was used to find the predictive risk factors for moderate to severe
depressive symptoms.

Results::
The study encompassed a group of 562 participants, achieving a response rate of 97.33%. Initially, a Google Form was distributed electronically to
the entire participant pool; however, 15 individuals declined to participate, resulting in a final sample size of 547 (n). Amongst the variables that
showed significant prevalence of moderate to severe depressive symptoms were age (P <0.001), sex (P <0.001), marital status (P <0.001),
occupation classification (P <0.001), religiosity (P <0.001), education level (P <0.001), job stress (P <0.001), domicile and residence (P <0.001),
responsibility towards family (P <0.001), post-traumatic stress disorder (PTSD) (P <0.001), consumption of alcohol (P <0.001), coronavirus
disease pandemic (P <0.001), employment status (P = 0.002), family size (P = 0.001), and smoking (P = 0.004). Amongst the variables, the subgroups
that showed significant predictive factors of moderate to severe depressive symptoms were the ages between 18 and 25 years old (P = 0.01),
the female gender (P <0.001), and low levels of religiosity (P <0.001).

Conclusion::
The prevalence of moderate-to-severe depressive symptoms was 48% (n=260). In our study on the prevalence of depression, we have investigated
several predictive factors, including age, gender, religiosity, and a history of prior depression diagnosis. While numerous factors contribute to
depression, additional research is imperative to identify and validate additional predictive factors.
Global Epidemiology, Clinical Features, Diagnosis and Current Therapeutic
Novelties in Migraine Therapy and their Prevention: A Narrative Review
Authors: Ali Mohammad Daud , Gayasuddin Qur Fehmida , Alam Md. Sarfaraz , M. Alotaibi Nawaf , Mujtaba Md. Ali 
Published: December 2023

Introduction::
The current article reviews the latest information on epidemiology, clinical features,
diagnosis, recent advancements in clinical management, current therapeutic novelties, and the prevention of
migraines. In a narrative review, all studies as per developed MeSH terms published until February 2023, excluding
those irrelevant, were identified through a PubMed literature search.

Methods::
Overall, migraine affects more than a billion people annually and is one of the most common neurological
illnesses. A wide range of comorbidities is associated with migraines, including stress and sleep disturbances.
To lower the worldwide burden of migraine, comprehensive efforts are required to develop and enhance
migraine treatment, which is supported by informed healthcare policy. Numerous migraine therapies
have been successful, but not all patients benefit from them.

Results::
CGRP pathway-targeted therapy demonstrates the importance of translating mechanistic understanding
into effective treatment. In this review, we discuss clinical features, diagnosis, and recently approved
drugs, as well as a number of potential therapeutic targets, including pituitary adenylate cyclase-activating
polypeptide (PACAP), adenosine, opioid receptors, potassium channels, transient receptor potential ion channels
(TRP), and acid-sensing ion channels (ASIC).

Conclusion::
In addition to providing more treatment options for improved clinical care, a better understanding
of these mechanisms facilitates the discovery of novel therapeutic targets.
Theoretical Evaluation of Oleocanthal Reactive Centers
Authors: Asgarshamsi Mohammad Hossein , Dehkordi Mehrdad Mohammadpour , Reza Nazifi Seyed Mohamad , Zborowski Krzysztof K. 
Published: December 2023

Background:
Decarboxymethyl ligstroside aglycone (oleocanthal) is an essential component of olive
oil. It is therefore interesting to study its metabolism in the human body. In order to find the best possible starting
point for this metabolism, a theoretical study was carried out using DFT calculations and docking studies.

Methods:
The DFT, B3LYP/6-311++G** and the PCM solvation model calculations were used to study the initial
process of oleocanthal metabolism by the CYP1A2 enzyme. Structures of radicals formed by homolytic dissociation
of hydrogen atoms from the oleocanthal structure were obtained and their properties were studied. Several
parameters such as HOMO and LUMO energy gaps, Bond Dissociation Energy (BDE), hardness, and spin density
of possible oleocanthal radicals were taken into account. Docking of oleocanthal into an enzyme binding pocket
was also performed to locate the most probably metabolic site. Detailed analysis of the theoretical results allows
the determination of the most likely reaction sites in oleocanthal. The mode of binding of oleocanthal to the
CYP1A2 enzyme was also predicted.

Results:
The results of the molecular docking studies are in agreement with the calculated quantum parameters.
The theoretical predictions were compared with experimental data available in the scientific literature. A high
correlation between theoretical calculations and experimental data was observed. The most likely site of oleocanthal
metabolism was identified.

Conclusion:
The results of our research support the usefulness of theoretical calculations in predicting metabolic
pathways.
Liposomal Doxorubicin In vitro and In vivo Assays in Non-small Cell Lung
Cancer: A Systematic Review
Authors: Redruello-Guerrero Pablo , Córdoba-Peláez Paula , Láinez-Ramos-Bossini Antonio Jesús , Rivera-Izquierdo Mario , Mesas Cristina , Ortiz Raul , Prados Jose , Perazzoli Gloria 
Published: December 2023

Background:
Liposomal Doxorubicin (Doxil®) was one of the first nanoformulations approved
for the treatment of solid tumors. Although there is already extensive experience in its use for
different tumors, there is currently no grouped evidence of its therapeutic benefits in non-small cell
lung cancer (NSCLC). A systematic review of the literature was performed on the therapeutic effectiveness
and benefits of Liposomal Doxil® in NSCLC.

Methods:
A total of 1022 articles were identified in publications up to 2020 (MEDLINE, Cochrane,
Web of Science Core Collection and Scopus). After applying inclusion criteria, the number was restricted
to 114, of which 48 assays, including in vitro (n=20) and in vivo (animals, n=35 and humans,
n=6) studies, were selected.

Results:
The maximum inhibitory concentration (IC50), tumor growth inhibition rate, response and
survival rates were the main indices for evaluating the efficacy and effectiveness of Liposomal DOX.
These have shown clear benefits both in vitro and in vivo, improving the IC50 of free DOX or untargeted
liposomes, depending on their size, administration, or targeting.

Conclusion:
Doxil® significantly reduced cellular proliferation in vitro and improved survival in vivo
in both experimental animals and NSCLC patients, demonstrating optimal safety and pharmacokinetic
behavior indices. Although our systematic review supports its benefits for the treatment of NSCLC,
additional clinical trials with larger sample sizes are necessary to obtain more precise clinical data on
its activity and effects in humans.
The Effect of Remote Ischemic Postconditioning on Quality of Life and Clinical Events after an Ischemic Stroke
Authors: Kerstens Thijs P. , Landman Thijs R.J. , Schoon Yvonne , Meijer Frederick J.A. , Warlé Michiel C. , de Leeuw Frank-Erik , Thijssen Dick H.J. 
Published: December 2023

Objectives:
Repeated remote ischemic postconditioning (rIPostC) may be an easily
applicable treatment following ischemic stroke to improve quality of life (QoL) and clinical outcomes.
rIPostC consists of repeated, brief periods of limb ischemia (through inflation of a blood
pressure cuff), followed by reperfusion. This study investigated the 1-year follow-up of rIPostC
on QoL and clinical events.

Methods:
As part of a randomized controlled trial, adult patients with an ischemic stroke within
24 hours after onset of symptoms were randomized to repeated rIPostC or sham-conditioning.
rIPostC was applied twice daily during hospitalization (maximum of 4 days). QoL and patientreported
outcome measures (PROMs) were assessed at 12-week and 1-year follow-ups. Additionally,
we explored the effect of repeated rIPostC on clinical events (recurrent cerebrovascular
events, hospitalization, and mortality).

Results:
The trial was preliminarily stopped due to limitations in recruitment after the inclusion
of 88 patients (rIPostC: 40; sham-conditioning: 48) (70 years, 68% male). Questionnaires were
returned by 69 (78%) and 63 (72%) participants after 12 weeks and 1 year, respectively. The
median difference of the stroke-specific QoL between rIPostC and sham-conditioning was 0.05
(p =0.986) and -0.16 (p =0.654) after 12 weeks and 1-year, respectively. No significant effect of
rIPostC on the different domains of PROMs was detected. We observed no between-group differences
in recurrent cerebrovascular events, hospitalization, or all-cause mortality (Hazard Ratios
p >0.05).

Conclusion:
In this exploratory analysis, we observed no significant difference between repeated
rIPostC and usual care on QoL and clinical outcomes at 12 weeks and 1 year in patients with
an ischemic stroke.

Clinical Trial Registration Number:
NTR6880.
Albumin-Globulin Ratio and Common Carotid Artery Intima-Media Thickness in Patients with Ischemic Stroke
Authors: Han Qiao , You Shoujiang , Miao Mengyuan , Zheng Danni , Du Huaping , Sun Yaming , Zhai Wanqing , Zhong Chongke , Cao Yongjun , Liu Chun-Feng 
Published: December 2023

Background:
The relationships between serum albumin, albumin-globulin (A/G) ratio,
globulin and atherosclerosis in acute ischemic stroke (AIS) remain uncertain. We investigated
the associations between serum albumin, A/G ratio, globulin levels and carotid atherosclerosis
in patients with AIS.

background:
The relationships between serum albumin, albumin-globulin (A/G) ratio, globulin and atherosclerosis in the setting of ischemic stroke are unclear.

Methods:
A total of 1,339 AIS patients were enrolled. Admission A/G ratio was divided into
quartiles, and serum albumin and globulin levels were also categorized. Carotid atherosclerosis
was detected through the assessment of common carotid artery intima-media thickness (cIMT),
and abnormal cIMT was characterized by mean and maximum cIMT values of ≥1 mm. We evaluated
the relationships between A/G ratio, albumin, globulin and abnormal cIMT, using multivariable
logistic regression models.

objective:
We aimed to evaluate the associations between serum albumin, A/G ratio, globulin levels and carotid atherosclerosis in patients with ischemic stroke.

Results:
In the multivariable-adjusted analysis, the highest A/G ratio quartile (Q4) was linked to
a 59% decreased risk of abnormal mean cIMT (OR 0.41; 95% CI 0.29-0.60) and a 58% decreased
risk of abnormal maximum cIMT (OR 0.42; 95% CI 0.30-0.60) when compared to the
lowest quartile (Q1), respectively. Moreover, decreased albumin and elevated globulin levels
were also associated with abnormal mean cIMT and maximum cIMT. In addition, the A/G ratio
provided supplementary predictive capability beyond the already established risk factors, and the
C-statistic of the A/G ratio for abnormal cIMT is larger than globulin (P <0.01).

Conclusion:
Decreased serum A/G ratio, albumin and elevated serum globulin were independently
associated with abnormal cIMT in AIS patients. Moreover, the A/G ratio appeared to
be a better predictor of abnormal cIMT.

result:
In the multivariable-adjusted analysis, the highest A/G ratio quartile (Q4) was associated with a 59% (OR 0.41; 95% CI 0.29-0.60) decreased risk of having abnormal mean cIMT and 58% (OR 0.42; 95% CI 0.30-0.60) decreased risk of having abnormal maximum cIMT in comparison to Q1, respectively. Moreover, decreased albumin and increased globulin levels were associated with abnormal mean cIMT and maximum cIMT. In addition, the A/G ratio provided incremental predictive capacity beyond established risk factors, and the C-statistic of A/G ratio for abnormal cIMT is larger than globulin (P<0.01).

conclusion:
Decreased serum A/G ratio, albumin and elevated serum globulin were independently associated with abnormal cIMT in patients with ischemic stroke. Moreover, the A/G ratio appeared to be a better predictor of abnormal cIMT.

other:
No
Association between Peripheral Arterial Lactate Levels and Malignant Brain Edema Following Endovascular Treatment for Ischemic Stroke
Authors: Wang Huiyuan , Yuan Ruozhen , Shen Panpan , Yu Xinyue , Chen Xinyi , Shang Yafei , Xu Jie , Tan Mingming , Zhang Sheng , Geng Yu 
Published: December 2023

Aims:
To investigate the factors of postoperative malignant brain edema (MBE) in
patients with acute ischemic stroke (AIS) treated with endovascular treatment (EVT).

Background:
MBE is a severe complication following EVT for AIS, and it is essential to identify
risk factors early. Peripheral arterial lactate (PAL) levels may serve as a potential predictive
marker for MBE.

Objective:
To determine whether immediate postoperative PAL levels and the highest PAL level
within 24 hours of EVT are independently associated with MBE development in AIS patients.

Methods:
We retrospectively analyzed patients with AIS who underwent EVT from October
2019 to October 2022. Arterial blood was collected every 8 h after EVT to measure PAL, and
record the immediate postoperative PAL and the highest PAL level within 24 h. Brain edema
was evaluated using brain computed tomography scans within 7 days of EVT.

Results:
The study included 227 patients with a median age of 71 years, of whom 59.5% were
male and MBE developed in 25.6% of patients (58/227). Multivariate logistic regression analysis
showed that the immediate postoperative PAL (odds ratio, 1.809 [95% confidence interval (CI),
1.215-2.693]; p = 0.004) and the highest PAL level within 24 h of EVT (odds ratio, 2.259 [95%
CI, 1.407-3.629]; p = 0.001) were independently associated with MBE. The area under the curve
for predicting MBE based on the highest PAL level within 24 hours of EVT was 0.780 (95% CI,
0.711-0.849).

Conclusion:
Early increase in PAL levels is an independent predictor of MBE after EVT in AIS patients.
Diagnostic Concordance and Discrepancies in 3D TVUS and MRI of Congenital
Uterine Malformations across the ASRM 2016, ASRM 2021, ESHRE/ESGE
2016, and CUME 2018
Authors: Gürses Cemil , Kılıç Koray 
Published: December 2023

Background::
The classification of Congenital Uterine Malformations (CONUTA) relies on coronal imaging of the uterus using 3D TVUS and MRI. In everyday
practice, radiologists and gynaecologists often struggle to confidently categorize CONUTA due to varying classification systems and the lack of
worldwide consensus.

Objectives::
The aim of this study was to evaluate the diagnostic concordance and discrepancies between two imaging techniques within the context of the
ASRM, ESHRE/ESGE, and CUME systems.

Methods::
Ninety-four patients suspected of having CONUTA underwent evaluation: 67 underwent 3D TVUS, 53 had MRI scans, and 34 were examined
using both imaging techniques.
An initial cross-listing table of ASRM, ESHRE/ESGE, and CUME was created, and a flowchart schema was used to define the type of congenital
uterine anomaly for each system
The prevalence of anomalies in each system was calculated, and Fleiss’ Kappa was used to assess and determine the level of agreement.

Results::
Class VI arcuate uterus was the most common form in ASRM 2016 and 2021, while the partially septate uterus predominated in the CUME 2018
and ESHRE/ESGE 2016 classification systems.

Conclusion::
There is no discordance between classification systems for all fusion defects and complete septate type of absorption defects. In the ESHRE/ESGE
system, nearly half of the abnormal uteruses were categorized as partially septate. However, the CUME system proved less effective in
distinguishing between normal and arcuate uteruses.