bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three‐dimensional printed Zn2SiO4/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair
Authors: Wang Yu , Jiao Yiren , Zeng Zhen , Chang Jiang , Yang Chen , Dong Zhihong 
Published: October 2023

AbstractThe intricate nature of the tendon–bone interface poses significant challenges for current surgical methods aimed at repairing tendon–bone interface injuries. Despite notable progress in surgical techniques, these methods continue to grapple with hurdles such as complications and suboptimal healing effects. In this study, we prepared a three‐dimensional‐printed composite scaffold by incorporating bioactive ceramic zinc silicate (Zn2SiO4) into sodium alginate (SA) hydrogel. The physicochemical properties and mechanical strength of the SA hydrogel scaffold composited with Zn2SiO4 (ZnSi/SA) were investigated in vitro. Impressively, the 0.5‐ZnSi/SA scaffold exhibited a sustained release of Zn and Si ions, while exhibiting mechanical properties compatible with tendon–bone interface repair. Moreover, cell viability, cell migration, and osteogenic differentiation assay results showed that 0.5‐ZnSi/SA scaffold facilitated the viability, mobility, and osteogenic differentiation of bone marrow stromal cells. In parallel, assessments of cell viability, cell migration, and tendon differentiation indicated that 0.5‐ZnSi/SA scaffold promoted the viability, migration, and tenogenic differentiation of tendon stem/progenitor cells. Moreover, cell viability, cell migration, and tube formation assay results demonstrated that 0.5‐ZnSi/SA scaffold enhanced the viability, migration rate, and angiogenic performance of human umbilical vein endothelial cells. Collectively, our findings suggest a promising therapeutic avenue employing ZnSi/SA scaffold for tendon–bone interface healing.
Movienet: Deep space–time‐coil reconstruction network without k‐space data consistency for fast motion‐resolved 4D MRI
Authors: Murray Victor , Siddiq Syed , Crane Christopher , El Homsi Maria , Kim Tae‐Hyung , Wu Can , Otazo Ricardo 
Published: October 2023

AbstractPurposeTo develop a novel deep learning approach for 4D‐MRI reconstruction, named Movienet, which exploits space–time‐coil correlations and motion preservation instead of k‐space data consistency, to accelerate the acquisition of golden‐angle radial data and enable subsecond reconstruction times in dynamic MRI.MethodsMovienet uses a U‐net architecture with modified residual learning blocks that operate entirely in the image domain to remove aliasing artifacts and reconstruct an unaliased motion‐resolved 4D image. Motion preservation is enforced by sorting the input image and reference for training in a linear motion order from expiration to inspiration. The input image was collected with a lower scan time than the reference XD‐GRASP image used for training. Movienet is demonstrated for motion‐resolved 4D MRI and motion‐resistant 3D MRI of abdominal tumors on a therapeutic 1.5T MR‐Linac (1.5‐fold acquisition acceleration) and diagnostic 3T MRI scanners (2‐fold and 2.25‐fold acquisition acceleration for 4D and 3D, respectively). Image quality was evaluated quantitatively and qualitatively by expert clinical readers.ResultsThe reconstruction time of Movienet was 0.69 s (4 motion states) and 0.75 s (10 motion states), which is substantially lower than iterative XD‐GRASP and unrolled reconstruction networks. Movienet enables faster acquisition than XD‐GRASP with similar overall image quality and improved suppression of streaking artifacts.ConclusionMovienet accelerates data acquisition with respect to compressed sensing and reconstructs 4D images in less than 1 s, which would enable an efficient implementation of 4D MRI in a clinical setting for fast motion‐resistant 3D anatomical imaging or motion‐resolved 4D imaging.
Durability of the liquid rubber‐modified CFRP‐steel interface under freeze–thaw cycles
Authors: Pang Yuyang , Li Zhenqi , Wang Qiang , Hao Jianbing , Gao Li , Tang Qun 
Published: October 2023

AbstractAn experimental investigation was carried out to evaluate the feasibility of using a liquid rubber‐modified epoxy resin to improve the bonding durability between steel and carbon fiber‐reinforced polymer (CFRP) plates in a freeze–thaw environment. Forty‐eight CFRP‐steel double strap joints were prepared, with a focus on two key factors: the number of freeze–thaw cycles (0, 50, 100, and 200 cycles) and the amount of liquid rubber in the adhesive (0%, 5%, 10%, and 15% by mass). The bond properties encompassing the damage mode, the ultimate capacity, and the bond–slip response of the CFRP‐steel joints were examined, respectively. The study revealed that the ultimate capacity of the joints decreased as the freeze–thaw cycles increased. The ultimate capacity retention rate for unmodified joints, after undergoing 200 freeze–thaw cycles, was approximately 84.9%, while for the modified joints, it ranged from 90.5% to 96.4%. Furthermore, the impact of the freeze–thaw cycles and liquid rubber content on the key bond indicators in terms of the maximum shear stress τmax, initial slip S1, maximum slip Sf, and fracture energy Gf were ascertained, leading to the establishment of the bond–slip degradation relationship of the liquid rubber modified CFRP‐steel interface under freeze–thaw environment.Highlights
The effects of the liquid rubber content and freeze–thaw cycles on the mechanical properties of the epoxy resin‐based adhesive were determined.
The influences of both the liquid rubber content and freeze–thaw cycles on the CFRP‐steel interface were analyzed.
The bond–slip degradation relationships of the liquid rubber‐modified CFRP–steel interface under freeze–thaw cycles were developed.
Bioactivities and chemical profiling comparison and metabolomic variations of polyphenolics and steroidal glycoalkaloids in different parts of Solanum nigrum L.
Authors: Zhang Qi , Liu Dongmei , Cui Yanru , Xu Tongxin , Lu Tiantian , Liu Xiaoli , Liu Kun , Wang Quande , Li Aiqian , Zhao Pengfei , Cheng Zhongzhe 
Published: October 2023

AbstractIntroductionSolanum nigrum L. is a traditional medicinal herb and edible plant. Many studies provide evidence that S. nigrum L. is a nutritious vegetable. Polyphenols and steroidal glycoalkaloids are the main components.ObjectivesThis study aimed to systemically evaluate the phytochemical profile, quantification, and bioactivities of polyphenolics and glycoalkaloids in different parts of S. nigrum L.ResultsTotal polyphenols (TPC) and total glycoalkaloids (TGK) were determined using the Folin–Ciocalteu and acid dye colorimetric methods, respectively. A total of 55 polyphenolic constituents (including 22 phenolic acids and 33 flavonoids) and 24 steroidal glycoalkaloids were identified from different parts using ultrahigh‐performance liquid chromatography Q‐exactive high‐resolution mass spectrometry (UHPLC‐QE‐HRMS), of which 40 polyphenols (including 15 phenolic acids and 25 flavonoids) and one steroidal glycoalkaloid were characterised for the first time in S. nigrum L. Moreover, typical polyphenols and glycoalkaloids were determined using HPLC‐UV and HPLC–evaporative light‐scattering detector (ELSD), respectively. In addition, the TPC and TGK and their typical constituents were compared in different anatomical parts. Finally, the antioxidant capacities of polyphenolic extracts from different parts of S. nigrum L. were evaluated by ·OH, 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging and ferric‐reducing antioxidant power (FRAP) assay in vitro. In addition, the antitumour effects of TGK from different parts of S. nigrum L. on the proliferation of PC‐3 cells were investigated using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay. Polyphenolic and glycoalkaloid extracts from different parts of S. nigrum L. showed different antioxidant and cytotoxic capacities in vitro.ConclusionThis is the first study to systematically differentiate between polyphenolic and glycoalkaloid profiles from different parts of S. nigrum L.
AFM dilatometry measurements on ultra‐stable fluoropolymer glasses: Further evidence of extreme fictive temperature reduction
Authors: El Banna Amer A. , McKenna Gregory B. 
Published: October 2023

AbstractUltra‐stable amorphous fluoropolymers glasses were created using vacuum pyrolysis deposition (VPD). Glass films with thickness ranging from 90 to 160 nm were grown at a substrate temperature of 0.86 Tg, where Tg is the glass transition temperature of the virgin polymer and is in units of K. Atomic force microscope (AFM) dilatometry measurements were conducted to investigate density behavior of the ultra‐stable glasses. Thickness measurements were made in stepwise fashion over a range of temperatures from ambient to above the Tg. Results show that the intersections of the line for the equilibrium liquid and those for the rejuvenated and stable glasses identifying the fictive temperature Tf result in Tf, rejuvenated = 347.3 K and Tf, stable = 269.5 K, that is, nearly 80 K below the Tg of the rejuvenated material and well below the notional Kauzmann temperature as estimated from the Vogel‐Fultcher‐Tammann (VFT) analysis of the cooling rate dependence of the calorimetric glass transition temperature reported previously. The results corroborate the published calorimetric results on the same ultra‐stable fluoropolymer glasses that witnessed Tf reductions of up to 62.6 K below the Tg of the rejuvenated system. In addition, to demonstrate the versatility of the AFM dilatometry methodology for the thin film response, isothermal de‐aging experiments were carried out to illustrate the devitrification kinetics. We also carried out one of the Kovacs’ signature key experiments, the asymmetry of approach, to further illustrate the method.
Shape and Phase‐Controlled One‐Pot Synthesis of Air Stable Cationic AgCdS Nanocrystals, Optoelectronic and Electrochemical Hydrogen Evolution Studies
Authors: Chaturvedi Jyotsna , Munthasir Akkarakkaran Thayyil Muhammed , Nayak Arpan Kumar , Tripathi Laxmi Narayan , Thilagar Pakkirisamy , Jagirdar Balaji R. 
Published: October 2023

AbstractCdS‐based materials are extensively studied for photocatalytic water splitting. By incorporating Ag+ into CdS nanomaterials, the catalyst's charge carrier dynamic can be tuned for photo‐electrochemical devices. However, photo‐corrosion and air‐stability of the heterostructures limit the photocatalytic device's performance. Here, a one‐pot, single molecular source synthesis of the air‐stable AgCdS ternary semiconductor alloy nanostructures by heat‐up method is reported. Monoclinic and hexagonal phases of the alloy are tuned by judicious choice of dodecane thiol (DDT), octadecyl amine (ODA), and oleyl amine (OLA) as capping agents. Transmission electron microscope (TEM) and powder X‐ray diffraction characterization of the AgCdS alloy confirm the monoclinic and hexagonal phase (wurtzite) formation. The high‐resolution TEM studies confirm the formation of AgCdS@DDT alloy nanorods and their shape transformation into nano‐triangles. The nanoparticle coalescence is observed for ODA‐capped alloys in the wurtzite phase. Moreover, OLA directs mixed crystal phases and anisotropic growth of alloy. Optical processes in AgCdS@DDT nano‐triangles show mono‐exponential decay (3.97 ± 0.01 ns). The monoclinic phase of the AgCdS@DDT nanorods exhibits higher electrochemical hydrogen evolution activity in neutral media as compared to the AgCdS@ODA/OLA alloy nanocrystals. DDT and OLA‐capped alloys display current densities of 14.1 and 14.7 mA cm−2, respectively, at 0.8 V (vs RHE).
Mutation testing optimisations using the Clang front‐end
Authors: Vercammen Sten , Demeyer Serge , Borg Markus , Pettersson Niklas , Hedin Görel 
Published: October 2023

AbstractMutation testing is the state‐of‐the‐art technique for assessing the fault detection capacity of a test suite. Unfortunately, a full mutation analysis is often prohibitively expensive. The CppCheck project for instance, demands a build time of 5.8 min and a test execution time of 17 s on our desktop computer. An unoptimised mutation analysis, for 55,000 generated mutants took 11.8 days in total, of which 4.3 days is spent on (re)compiling the project. In this paper, we present a feasibility study, investigating how a number of optimisation strategies can be implemented based on the Clang front‐end. These optimisation strategies allow to eliminate the compilation and execution overhead in order to support efficient mutation testing for the C language family. We provide a proof‐of‐concept tool that achieves a speedup of between 2
and 30
. We make a detailed analysis of the speedup induced by the optimisations, elaborate on the lessons learned and point out avenues for further improvements.
Synthesis of stable iodoplumbate and perovskite for efficient annealing‐free device and long‐term storage
Authors: Kim Jihyun , Park Sang‐Won , Lee Younghyun , Hosono Hideo , Park Byungwoo , Kim Jinhyun 
Published: October 2023

AbstractAs a next‐generation photovoltaic device, perovskite solar cells are rapidly emerging. Nevertheless, both solution and device stability pose challenges for commercialization due to chemical degradation caused by internal and external factors. Especially, the decomposition of iodoplumbate in a perovskite solution hinders the long‐term use of perovskite solutions. Moreover, the synthesis of stable perovskites at low temperature is important for stable devices and wide applications (flexible devices and high reproducibility). Herein, the critical composition of perovskite is found to obtain high stabilities of both iodoplumbate and perovskite crystals by utilizing CsPbBr3 and FAPbI3, exhibiting high device performance and long‐term solution storage. The novel composition of CsPbBr3‐alloyed FAPbI3 not only crystallizes under annealing‐free conditions but also demonstrates excellent iodoplumbate stability for 100 days (∼3000 h) without any degradation. Furthermore, high device stabilities are achieved over 2000 and 3000 h under extreme conditions of A.M. 1.5 and 85°C/85% relative humidity, respectively. Overall, the device exhibited a high power conversion efficiency of 23.4%, and furthermore, CsPbBr3‐alloyed FAPbI3 was devoted to widen the applications in both flexible and carbon‐electrode devices, thereby addressing both scientific depths and potential commercial materials.
Validation of Reference Frame Consistency of GNSS Service Products
Authors: Huisman Lennard , de Ligt Huib 
Published: October 2023

AbstractIn Global Navigation Sattelite System (GNSS) point positioning the coordinate reference frame of the positioning results is determined by the reference frame of the used GNSS service product. These products include broadcast ephemeris, precise orbits, clocks, biases, and reference station observations. Consistency in the reference frame is crucial for analyzing coordinate differences and velocities in earth science and geomatics applications. National agencies calculate coordinates for GNSS reference stations to ensure reference frame consistency within a country, however this approach is not suitable for providers covering multiple countries.This contribution will introduce two new approaches for reference frame validation of GNSS service products and their relation with the International Association of Geodesy’s Reference Frame Sub-Commission for Europe (EUREF) densification guidelines, including results of a first prototype assessing the consistency of a cross-border GNSS RTK service with the EUREF Permanent Network (EPN) reference frame ETRF2000 and consistency of a GNSS PPP service with the International GNSS Service reference frame IGb14.
Wave scattering event shapes at high energies
Authors: Gonzo Riccardo , Ilderton Anton 
Published: October 2023

Abstract
We study the space and properties of global and local observables for radiation emitted in the scattering of a massive scalar field in gauge and gravitational plane-wave backgrounds, in both the quantum and classical theory. We first compute the radiated momentum and angular momentum flow, demonstrating that they are good local observables determined by the amplitude and phase of the waveform. We then focus on the corresponding global observables, which in the gravitational case requires dealing with the collinear divergence of the gravitational Compton cross-section. We show using the KLN theorem that we can obtain an infrared-finite cross-section only by summing over forward scattering diagrams; this suggests dressing the initial state in the direction collinear to the plane wave in order to be able to compute observables integrated over the celestial sphere. Finally, we explore the high-energy behaviour of our observables. We find that classical global observables generically exhibit a power-law mass divergence in electrodynamics and a logarithmic mass divergence in gravity, even when radiation reaction is included. We then show explicitly how this is consistently resolved in the full quantum theory.
The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants
Authors: Nilles Julie , Weiss Johanna , Masin Martin , Tuffs Christopher , Strowitzki Moritz J. , Haefeli Walter E. , Ruez Stephanie , Theile Dirk 
Published: October 2023

AbstractRifampicin and rifabutin can activate the pregnane X receptor (PXR, NR1I2), thereby inducing pharmacokinetically important genes/proteins and reducing exposure to co-administered drugs. Because induction effects vary considerably between these antibiotics, differences could be due to unequal rifamycin-induced activation or tissue expression of the three major NR1I2 splice variants, PXR.1 (NM_003889), PXR.2 (NM_022002), and PXR.3 (NM_033013). Consequently, PXR activation (PXR reporter gene assays) and mRNA expression levels of total NR1I2, PXR.1, PXR.2, and PXR.3 were investigated by polymerase chain reaction in colon and liver samples from eleven surgical patients, in LS180 cells, and primary human hepatocytes. Compared to the colon, total NR1I2 mRNA expression was higher in the liver. Both tissues showed similar expression levels of PXR.1 and PXR.3, respectively. PXR.2 was not quantifiable in the colon samples. Rifampicin and rifabutin similarly enhanced PXR.1 and PXR.2 activity when transfected into LS180 cells, while PXR.3 could not be activated. In LS180 cells, rifampicin (10 μM) reduced total NR1I2 and PXR.3 expression 2-fold after 24 h, while rifabutin (10 μM) increased total NR1I2, PXR.1, PXR.2, and PXR.3 mRNA by approx. 50% after 96-h exposure. In primary human hepatocytes, rifampicin (10 μM) suppressed total NR1I2, PXR.1, and PXR.3 after 48-h exposure, and rifabutin (10 μM) had no significant impact on total NR1I2 or any of the splice variants studied. In conclusion, both antibiotics activated the studied PXR splice variants similarly but modified their expression differently. While rifampicin can suppress mRNA of PXR forms, rifabutin rather increases their expression levels.
The Influence of Scar Patterns After Reduction Mammoplasty on Eye Movement and Gaze Pattern: An Eye-Tracking Investigation
Authors: Frank Konstantin , Zeng Rui , Sedlbauer Stephanie , Prantl Lukas , Giunta Riccardo , Cotofana Sebastian , Moellhoff Nicholas , Alfertshofer Michael , Kaye Kai , Brébant Vanessa 
Published: October 2023

Abstract
Background
Given that scars are acknowledged as the primary cause of postoperative dissatisfaction following reduction mammoplasty, it is imperative to comprehend the patient’s visual perception of different scar patterns in order to enhance patient satisfaction. To achieve this, eye-tracking technology provides an unbiased method of evaluating how observers assess breast scars.

Methods
58 participants (32 females and 26 males) between the ages of 19 and 82 years (mean age of 29.47 ± 10.98 years) were shown 18 color photographs, taken at 3 viewing angles (right 45° oblique, frontal and frontal view with arms raised), from 6 patients undergone reduction mammoplasty with the inverted T-scar technique (3 patients) or no-vertical-scar technique (3 patients). The images were presented to every participant for a fixed duration of 5 s each. Eye-tracking device was used to collect and analyze the gaze data of viewers.

Results
The nipple-areola complex (NAC) and the periareolar scar captured observers’ gaze faster, had longer duration and more count of eye fixation than all other parts of breast scars, regardless of the viewing angle and scar pattern. Moreover, the scar region in the inverted T-scar pattern received greater and faster visual attraction of observer’s gaze than the no-vertical-scar pattern.

Conclusion
The NAC and the periareolar scar seem to be perceived as the most important regions for breast aesthetics. The findings can be helpful to assist plastic surgeons in determining the most appropriate technique for reduction mammoplasty, meanwhile underlining the importance of a fine periareolar scar and symmetric NAC for excellent aesthetic outcomes.

This is to our best knowledge the first study using eye-tracking technology in evaluating reduction mammoplasty outcomes.

This study explored the influence of different scar patterns after reduction mammoplasty on eye movements and gaze patterns among observers.

The study have validated the significance of the NAC and the periareolar scar for breast aesthetics and revealed that the scar region in the inverted T-scar pattern may be judged less visually attractive than the no-vertical-scar pattern.

Level of Evidence V
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas
Authors: de Haan Lorraine M. , de Groen Ruben A. L. , de Groot Fleur A. , Noordenbos Troy , van Wezel Tom , van Eijk Ronald , Ruano Dina , Diepstra Arjan , Koens Lianne , Nicolae-Cristea Alina , Hartog Wietske C. E. den , Terpstra Valeska , Ahsmann Els , Dekker Tim J. A. , Sijs-Szabo Aniko , Veelken Hendrik , Cleven Arjen H. G. , Jansen Patty M. , Vermaat Joost S. P. 
Published: October 2023

AbstractPrevious studies in patients with mature B-cell lymphomas (MBCL) have shown that pathogenic TP53 aberrations are associated with inferior chemotherapeutic efficacy and survival outcomes. In solid malignancies, p53 immunohistochemistry is commonly used as a surrogate marker to assess TP53 mutations, but this correlation is not yet well-established in lymphomas. This study evaluated the accuracy of p53 immunohistochemistry as a surrogate marker for TP53 mutational analysis in a large real-world patient cohort of 354 MBCL patients within routine diagnostic practice. For each case, p53 IHC was assigned to one of three categories: wild type (staining 1–50% of tumor cells with variable nuclear staining), abnormal complete absence or abnormal overexpression (strong and diffuse staining > 50% of tumor cells). Pathogenic variants of TP53 were identified with a targeted next generation sequencing (tNGS) panel. Wild type p53 expression was observed in 267 cases (75.4%), complete absence in twenty cases (5.7%) and the overexpression pattern in 67 cases (18.9%). tNGS identified a pathogenic TP53 mutation in 102 patients (29%). The overall accuracy of p53 IHC was 84.5% (95% CI 80.3–88.1), with a robust specificity of 92.1% (95% CI 88.0- 95.1), but a low sensitivity of 65.7% (95% CI 55.7–74.8). These results suggest that the performance of p53 IHC is insufficient as a surrogate marker for TP53 mutations in our real-world routine diagnostic workup of MBCL patients. By using p53 immunohistochemistry alone, there is a significant risk a TP53 mutation will be missed, resulting in misevaluation of a high-risk patient. Therefore, molecular analysis is recommended in all MBCL patients, especially for further development of risk-directed therapies based on TP53 mutation status.