bluuebunny/crossref_metadata_2025_split huggingface dataset:
CRITICAL ANALYSIS OF POWDER FLOW BEHAVIOUR OF DIRECTLY COMPRESSIBLE COPROCESSED EXCIPIENTS
Authors: Salim Ilyasu , Khalid Garba Mohammed , Wada Abubakar Sadiq , Danladi Suleiman , Kurfi Fatima Shuaibu , Yola Umar Abdurrahman 
Published: February 2024

The aim of this pre-formulation study was to adopt simple linear regression modelling and correlation statistics to understand the associations between pharmacopoeial powder test methods using datasets generated from five commercial brands of directly compressible excipients with a specific focus to inferential implications in formulation design. Powder characterization was conducted using protocols defined in Chapter <1174> and <616> of the United States Pharmacopoeia (USP41-NF36). The study adopted a linear regression modelling analytics and correlation statistics using the fitting algorithm of OriginPro® (OriginPro, Version 2021b, OriginLab Corporation, Northampton, MA, USA). In the results, the modulus of Pearson’s product moment correlation coefficient was used to measure the strength of the linear association between test variables and a correlation matrix generated. Strong positive correlation modulus of Hausner’s Ratio (HR) with Carr’s index (r=+0.999) and static angle of repose (r=+0.932) were evident. Bulk density strongly correlates with tap density in the positive direction (r=+0.911). Tap density also shows a slight negative correlation with HR (r=-0.230), Carr’s index (r=-0.228), and static angle of repose (r==-0.421), while Carr’s index strongly correlated with static angle of repose (r=+0.933). In conclusion, modelling bivariate powder flow datasets has provided a powerful but simplistic statistical relationship for characterizing the modulus of association between HR, Carr’s index, and static angle of repose of the model excipients useful in preformulation design of pharmaceutical formulations.
Effect of Processing Parameters and Wall Thickness on the Strength of Injection Molded Products
Authors: Horváth Szabolcs , Kovács József Gábor 
Published: February 2024

Polymer materials are getting more and more attention in key industries like the automotive, aerospace, and electrical industries. A long lifetime with sustainable recycling is expected; great results are possible thanks to modern material engineering. Finding a suitable material for the purpose and the appropriate methods to test the required functionality is essential. An important mechanical loading tests is the tensile test. Although the ISO 527-1:2019 standard uses different tensile specimen geometries, none of those consider the possible thickness variations of the injection molded parts. If thickness is reduced to 1 mm, the solid layer will be dominant, which makes the properties of the tensile specimen process-dependent instead of material-dependent. In today's industry, it is crucial to examine both the material and the details of the processing technology together, given the downsizing effect.
دراسة مقارنة لمستوى بعض عناصر اللياقة البدنية بين طلاب مدرستي ثانوية نينوى للمتميزين وثانوية نينوى للمتفوقين في مدينة الموصل
Authors: Teacher.Dr. Anmar Abdel Moneim Younis  
Published: February 2024

هدف البحث الى التعرف على الفروق لمستوى بعض عناصر اللياقة البدنية بين طلاب مدرستي ثانوية نينوى للمتميزين وثانوية نينوى للمتفوقين في مدينة الموصل. تم استخدام المنهج التجريبي لملائمته وطبيعة البحث, تم تحديد مجتمع البحث بطلاب الصف الخامس الاعدادي في مدرستي ثانوية نينوى للمتميزين وثانوية نينوى للمتفوقين في محافظة نينوى للعام الدراسي 2022-2023 والبالغ عددهم (137) طالبا, أما عينة البحث فتكونت من طلاب الصف الخامس الاعدادي في ثانوية نينوى للمتميزين شعبة(أ) والبالغ عددهم (35) طالبا ومن طلاب الصف الخامس الاعدادي في ثانوية نينوى للمتفوقين شعبة (أ) والبالغ عددهم (37) طالبا, وبذلك اصبح عدد عينة البحث للمدرستين (72) طالبا وبنسبة مئوية بلغت (52,55%), وتم تحديد عناصر اللياقة البدنية الخاصة بالبحث وبعدها تم تحديد اهم الاختبارات البدنية الخاصة بالعناصر البدنية قيد الدراسة من خلال عرضها على الخبراء واجرت المعاملات العلمية للاختبارات المرشحة وتم استخدام الوسائل الاحصائية الاتية( الوسط الحسابي, الانحراف المعياري, النسبة المئوية, معامل الارتباط البسيط (بيرسون), اختبار (ت)) وقد تمت معالجة البيانات باستخدام الحزم الاحصائية (SPSS).
واستنتج الباحث ما يأتي:
• عدم وجود فروق ذات دلالة معنوية بين ثانوية نينوى للمتميزين وثانوية نينوى لللمتفوقين في اختبار (العدو 20م من الوقوف). اختبار (القفز العريض من الثبات). اختبار (الركض المتعرج بطريقة بارو). اختبار (ثني الجذع امام اسفل من الوقوف).
Tecno-adicción: una revisión sistemática de literatura desde la visión pedagógica con enfoque en el mejoramiento del proceso enseñanza – aprendizaje
Authors: Paredes Zambrano Jenny Lucia , Herrera Ojeda María Micaela , Guerrero Hernández Álvaro Sebastián , Zambrano Cruz Náthaly Sofía 
Published: February 2024

Introducción. Las Tecnologías de la Información y la Comunicación (TIC) indudablemente han generado beneficios en los campos educativos, laborales, y sociales influyendo en el diario vivir de las personas; sin embargo, su uso excesivo ha originado efectos desfavorables en los niños, niñas, adolescentes y en la juventud; así, incrementa el aislamiento, la ansiedad, la fatiga mental; mientras en la educación ha intensificado el cansancio, falta de atención, el desinterés en la realización y el cumplimiento de actividades escolares. Objetivo. Documentar mediante una revisión sistemática de literatura las publicaciones relacionadas con la tecno adicción desde una visión pedagógica con enfoque en el mejoramiento del proceso enseñanza – aprendizaje, abordando los conceptos, la importancia y consecuencias. Metodología. Corresponde a un estudio cualitativo, se aplicó la investigación acción con revisión de literatura en distintas fuentes como en el buscador Google académico, la base de datos E-Book y EBSCOhost, los repositorios de trabajos de post grado, en libros y revistas virtuales, utilizando un total de 40 divulgaciones, la modalidad fue bibliográfica documental, la tipología fue descriptiva. Resultados. en la nueva sociedad globalizada es indispensable fomentar en las instituciones educativas la comunicación eficiente, la reflexión y el liderazgo, aspectos que tienen una marcada relación con las tecnologías. Conclusión. Existe la necesidad de orientar a los padres, que guíen a sus hijos en el manejo adecuado de la conectividad; además en las instituciones educativas la creación de espacios interactivos permitirá prevenir las conductas de riesgo. Área de estudio general: Tecnologías de la información y comunicación. Área de estudio específica: Proceso enseñanza – aprendizaje.
One-year Outcomes of Ultrathin Descemet Stripping Automated Endothelial Keratoplasty Combined with Cataract Surgery in the Korean Population
Authors: Koo Minjeong Ashley , Yoon Hye Yeon , Park Jae Hyun , Chung So-Hyang , Kim Hyun‐Seung , Byun Yong-Soo 
Published: February 2024

Purpose: To evaluate the refractive outcomes after ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) combined with phacoemulsification and intraocular lens implantation (triple procedure) in the South Korean population.Methods: This retrospective observational study included 37 eyes of 36 patients who underwent the UT-DSAEK triple procedure between 2012 and 2021 in a single tertiary hospital. Preoperative and postoperative refractive outcomes and endothelial parameters at 1, 3, 6, and 12 months were observed.Results: At the final postoperative 12-month period, the average best-corrected visual acuity was 0.4 ± 0.5 in logarithm of the minimum angle of resolution. The mean endothelial cell density at 12 months was 1,841.92 ± 731.24 cells/mm<sup>2</sup>, indicating no significant endothelial cell loss compared to the baseline (<i>p</i> = 0.128). The mean postoperative central corneal thickness at 12 months was 597.41 ± 86.26 μm. The postoperative mean absolute error at 12 months was 0.96 ± 0.89 diopters (D) and mean error was 0.89 ± 0.97 D.Conclusions: The results of our South Korean cohort study on UT-DSAEK triple surgery showed favorable and safe outcomes. Regardless of graft thickness, it should be noted that a hyperopic shift of 1.00 to 2.00 D needs to be considered in the case of UT-DSAEK triple surgery.
Revisão bibliográfica narrativa: Lipoenxertia no tratamento de feridas lácero-contusas
Authors: Procópio Bianca Botelho , Faria Isadora Silva de , Schincaglia Júlia Augusto , Neves Lívia Marliere Giupponi , Macedo Maria Júlia Andrini , Kaminski Valéria Lima , Rangel Maysa Alves Rodrigues Brandão 
Published: February 2024

A lipoenxertia consiste na coleta de gordura pelo processo de lipoaspiração, e usado no preenchimento para correções de defeitos de tecidos moles. Pode ser utilizado no processo de cicatrização de diversas feridas, sendo a apresentada no presente trabalho a lácero-contusa. O enxerto de pele é uma técnica utilizada para cobertura de defeitos de pele, em lesões de regiões de difícil fechamento primário. Tem como objetivo verificar se a lipoenxertia tem o melhor prognóstico para cicatrização que o auto enxerto de pele em pacientes com feridas lácero-contusas. Como metodologia utilizada foi uma pesquisa bibliográfica inarrativa de 10 artigos referende ao tema, comparando os prognósticos das duas técnicas. Segundo alguns artigos lidos foram apresentados os benefícios em diversos pacientes, em relação a diminuição de tempo na recuperação, menor morbidade e melhora nos resultados que foram estabelecidos inicialmente.
Fatores associados a manutenção e interrupção do aleitamento materno exclusivo: uma revisão de literatura
Authors: Mendes Francislady Helilene Santos , Araújo Gardenea , Nascimento Ellaine Cristiane F. , Costa Francisca Jessica Lima dos Santos , Alves Thelma Cristina Pires , Marques Talga Monique Naiva Coelho , Rebêlo Kênia Regina Lima de Carvalho 
Published: February 2024

O aleitamento materno é ideal para o suprimento das necessidades alimentares e nutricionais durante os primeiros seis meses de vida trazendo diversos benefícios não só para o recém-nascido, mas também para a mãe e à família. A recomendação para boas práticas do aleitamento materno exclusivo é até os seis meses de idade. O objetivo desta pesquisa foi identificar na literatura os fatores associados à manutenção e/ou interrupção do aleitamento materno exclusivo nos primeiros seis meses de vida no Brasil. Trata-se de uma revisão integrativa da literatura, os dados foram coletados nas bases de dados: Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), SCIELO e BDENF, além das bases PUBMED e SCOPUS, totalizando 10 artigos após aplicação dos filtros selecionados. Com base nos resultados, a adesão ao aleitamento ou desmame precoce está associada a assistência prestada pelos profissionais durante o acompanhamento pré-natal. São vários os fatores contribuintes para a interrupção, como a baixa escolaridade materna, maior tempo de internação na Unidade de Tratamento Intensivo Neonatal (UTIN), falta de informação e estímulo por parte dos profissionais e a percepção materna de não ter uma quantidade suficiente de leite. A experiência prévia com amamentação mostrou-se ser um fator importante para a manutenção do aleitamento materno exclusivo. Além disso, traz o papel da família e/ou rede de apoio da mãe para manutenção, o que foi contrário a alguns achados da literatura, enfatizando que esta realidade não é homogênea.
Recent developments and future prospects of magnesium–sulfur batteries
Authors: Wang Liping , Riedel Sibylle , Drews Janina , Zhao-Karger Zhirong 
Published: February 2024

Rechargeable magnesium (Mg) batteries are promising candidates for the next-generation of energy storage systems due to their potential high-energy density, intrinsic safety features and cost-effectiveness. Among the various electrochemical couples, the combination of an Mg anode with a sulfur (S) cathode stands out as an attractive option, as it offers a remarkable theoretical volumetric energy density exceeding 3,200 Wh L–1. However, owing to the unique properties of Mg-ion electrolytes, Mg polysulfides and the surface passivation of Mg metal anodes, the development of Mg–S batteries is facing multiple challenges. In this review, recent advancements in designing efficient electrolytes for Mg–S battery systems are summarized. Apart from electrolytes, we also discuss the progress made in fabricating new S cathode composites, Mg anodes and functional separators, focusing on their roles in addressing the critical issues of the Mg–S systems. Finally, it is worth pointing out that the collaborative research combining experimental investigations and theoretical modelling could provide deeper insights into the mechanisms of Mg–S battery systems and promote their development. Overall, the comprehensive insights about the S-redox reaction, polysulfide shuttle problems and degradation mechanism in Mg–S batteries are discussed, which is of profound importance for creating solutions to enhance the overall performance of Mg–S batteries. This review aims to providing an overview of the current state of the research to stimulate innovative thoughts on the fundamental guidelines for facilitating development of Mg–S batteries.
A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant
Authors: Yu Xueying , Li Xiaoguang , Xia Shuai , Lu Lu , Fan Jiahui , Wang Ying , Fu Yan , Suo Chen , Man Qiuhong , Xiong Lize 
Published: February 2024

IntroductionMyocardial injury in elderly Omicron variant patients is a leading cause of severe disease and death. This study focuses on elucidating the clinical characteristics and potential risk factors associated with myocardial injury in elderly patients infected with the Omicron variant.MethodsMyocardial injury was defined based on elevated cardiac troponin concentrations exceeding the 99th percentile upper reference limit. Among 772 elderly Omicron-infected patients, categorized into myocardial injury (n = 263) and non-myocardial injury (n = 509) groups. The stratified log-rank statistic was used to compare the probability of patients developing intensive care. Receiver operating characteristic curves were used to determine the best cut-off values of clinical and laboratory data for predicting myocardial injury. Univariate and multivariate logistic regression was adopted to analyze the risk factors for myocardial injury.ResultsThe occurrence of myocardial injury in Omicron variant-infected geriatric patients was up to 34.07% and these patients may have a higher rate of requiring intensive care (P &lt; 0.05). By comparing myocardial injury patients with non-myocardial injury patients, notable differences were observed in age, pre-existing medical conditions (e.g., hypertension, coronary heart disease, cerebrovascular disease, arrhythmia, chronic kidney disease, and heart failure), and various laboratory biomarkers, including cycle threshold-ORF1ab gene (Ct-ORF1ab), cycle threshold-N gene (Ct-N), white blood cell count, neutrophil (NEUT) count, NEUT%, lymphocyte (LYM) count, LYM%, and D-dimer, interleukin-6, procalcitonin, C-reactive protein, serum amyloid A, total protein, lactate dehydrogenase, aspartate aminotransferase, glomerular filtration rate, blood urea nitrogen, and serum creatinine (sCr) levels (P &lt; 0.05). Furthermore, in the multivariable logistic regression, we identified potential risk factors for myocardial injury in Omicron variant–infected elderly patients, including advanced age, pre-existing coronary artery disease, interleukin-6 &gt; 22.69 pg/ml, procalcitonin &gt; 0.0435 ng/ml, D-dimer &gt; 0.615 mg/L, and sCr &gt; 81.30 μmol/L.ConclusionThis study revealed the clinical characteristics and potential risk factors associated with myocardial injury that enable early diagnosis of myocardial injury in Omicron variant-infected elderly patients, providing important reference indicators for early diagnosis and timely clinical intervention.
Case Report: Giant left atrial cystic tumor: myxoma or intracardiac blood cyst?
Authors: Xiao Weizhang , Qin Jing , Feng Jia , Jiang Feng , Chen Xinming , Cao Xiang , Xue Qun , Shi Jiahai 
Published: February 2024

BackgroundPrimary cardiac tumors are uncommon, with the majority being benign myxomas. Cystic myxoma, a particularly rare type of benign cardiac tumor, demands cautious differential diagnosis from other cardiac tumors.Case summaryA 43-year-old male patient presenting with intermittent dyspnea was referred to our department for surgical evaluation. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) unveiled an intra-left atrial cyst, which was subsequently found to be blood-filled during a video-assisted microinvasive heart surgery. Pathological examination depicted a cyst wall filled with small stellate and fat spindle cells, along with a mucoid matrix, indicating a diagnosis of cystic myxoma.ConclusionsWe herein presented a rare case of an adult patient with cystic myxoma, initially misdiagnosed as an intracardiac blood cyst (CBC) prior to surgery, and ultimately verified via pathological findings.
Anti-hypertensive effect of a novel angiotensin II receptor neprilysin inhibitor (ARNi) -S086 in DSS rat model
Authors: Sun Jingchao , Xiao Ying , Xu Wenjie , Xing Wei , Du Frank , Tian Maozhi , Xu Danqi , Ren Yihua , Fang Xin 
Published: February 2024

IntroductionAngiotensin receptor-neprilysin inhibitor (ARNi), comprised of an angiotensin receptor blocker (ARB) and a neprilysin inhibitor (NEPi), has established itself as a safe and effective intervention for hypertension. S086 is a novel ARNi cocrystal developed by Salubris for the treatment of heart failure and hypertension.MethodsDahl Salt Sensitive (DSS) hypertensive rat model and telemetry system were employed in this study to investigate the anti-hypertensive efficacy of S086 and compare it with the first ARNi-LCZ696.Results and discussionThe study showed that oral administration of S086 dose-dependently lowered blood pressure (P &lt; 0.001). The middle dosage of S086 (23 mg/kg) exhibited efficacy comparable to LCZ696 (68 mg/kg), while also demonstrating superiority at specific time points (P &lt; 0.05). Notably, water consumption slightly decreased post-treatment compared to the vehicle group. Furthermore, there were significant increases in natriuresis and diuresis observed on the first day of treatment with 23 mg/kg and 68 mg/kg S086 (P &lt; 0.001). However, over the course of treatment, the effects in all treatment groups gradually diminished. This study demonstrates the anti-hypertensive efficacy of S086 in DSS hypertensive rat model, offering promising avenues for the clinical development of S086 as a hypertension treatment.
Teaching comprehensive sexuality education in a traumatized society: recognizing teachers as sexual, reproductive, and mental health frontline workers
Authors: Macleod Catriona Ida , du Plessis Ulandi 
Published: February 2024

IntroductionResearch on school-based sexuality education in South Africa, taught within Life Orientation (LO), has mainly focused on learners’ responses, how teachers approach the subject, and the curriculum content. Critiques have included heteronormative biases, an emphasis on danger, disease and damage, a reinforcement of gendered binaries, and the lack of pleasure or well-being discourses. In contrast, our research focused on the unexpected moments teachers experience, i.e., the ethical, emotional or psychological challenges they encounter in their interactions with learners.MethodsWe interviewed 49 teachers across a range of schools in three provinces. Data were analyzed using narrative thematic analysis.ResultsTeachers’ narratives referred to an alarming array of traumas and psychosocial problems experienced by learners, including sexual abuse, substance abuse, neglect, HIV diagnosis, unsafe abortion, witnessing murders, and attempted suicide. Teaching particular topics, they indicated, triggered learner distress, although, sometimes, distress was triggered by innocuous topics. Teachers felt insufficiently skilled to teach certain topics sensitively to promote the well-being of learners who experienced current or past trauma. They also felt ill-equipped to deal with learners reporting trauma or psychosocial problems to them. Strategies narrated included allowing learners to skip relevant classes, building trust, understanding learners’ needs, being a learner’s advocate, and drawing on learners’ grounded expertise. Teachers spoke of experiencing burnout and secondary trauma themselves.DiscussionWe argue that LO teachers are, in effect, sexual, reproductive and mental health frontline workers. They need in-depth training in learner-centered and dialogical approaches to build trust within the classroom sensitively and in basic screening, containment, referral and lay counselling skills to assist distressed learners outside the class. A wellbeing approach to sexuality education requires providing LO teachers with ongoing support and consultation with peers and mental health professionals to avoid burnout and promote well-being.
The characteristics of soil salinization effects on nitrogen mineralization and nitrification in upland fields
Authors: Tao Yinglu , Xie Wenjun , Xu Lei , Zhang Lichang , Wang Guangmei , Wang Xiaoning , Shi Cailing 
Published: February 2024

The influence of soil salinization on nitrogen (N) transformation is largely unknown, which impedes the reasonable management of N in saline fields. A comprehensive meta-analysis was thus conducted to evaluate the effects of salinity and relative soil physicochemical properties on net N mineralization and nitrification in upland soils. Results showed that effects of salinity on the net-N mineralization rate (Min) and nitrification rate (Nit) changed with the salinity level and incubation time. Generally, the inhibitory effect of salt on Min and Nit decreased gradually with incubation time. At 14–16 days of soil incubation, significant stimulatory effects on Min were observed in middle-level (ECe: 12–16 dS m-1) and high-level (ECe &gt;16 dS m-1) saline soils, and on Nit in low-level (ECe: 4–12 dS m-1) saline soils. Regression analysis revealed that the effects of soil organic carbon (SOC), total N (TN), C/N, pH, and clay content on Min and Nit were closely related to salinity levels. Nit at 5–7 days of soil incubation first enhanced and then decreased with C/N increase, and the threshold value was 34.7. The effect of pH on Nit changed with salinity levels, and shifted from stimulation to inhibition with increasing pH. Min at 5–7 days of soil incubation in middle-level group first increased with increasing pH, and decreased when pH was higher than 8.1. Salinization deeply affected soil properties, which further influenced N turnover via alteration of the availability of substrates and microbial biomass and activities. Our findings suggest that the influence of salinity on soil N turnover closely related with salinity level, and salinity level should be considered fully when optimizing N management in saline upland fields.