bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfaatan Fitur Facebook sebagai Upaya dalam Meningkatkan Penjualan Produk UMKM di Ujungpangkah Kabupaten Gresik
Authors: Permata Regita Putri , Alifah Amalia Nur , Fadhilah Helisyah Nur 
Published: February 2024

Masih rendahnya kemampuan pelaku usaha dalam mengelola dan mengembangkan produk usahanya di Pangkah Wetan Gresik disebabkan terbatasnya pengetahuan tentang digitalisasi dan kemampuan dalam memasarkan produk secara online. Hal ini menjadi permasalahan yang dihadapi akibat terbatasnya literasi digital dalam menunjang kegiatan wirausaha berbasis potensi unggulan local. Kegiatan pengabdian ini bertujuan untuk meningkatkan literasi digital bagi para pelaku usaha UMKM dengan memanfaatkan fitur sosial media salah satunya Facebook Marketplace sebagai lapak jual online. Penjualan secara online dapat meningkatkan jumlah pelanggan dan meningkatkan omset. Metode pengabdian dilaksanakan melalui kegiatan pelatihan dengan pendekatan kooperatif-partisipatif. Hasil pengabdian menunjukkan foto produk olahan diunggah dan dijual melalui Facebook Marketplace. Hasil penelitian menunjukkan bahwa sebanyak 62,5% sudah menginstall dan mencoba membuka dan mempraktekkan Facebook Marketplace serta rata-rata postest meningkat dari 5.4 menjadi 6.5 dari skor rata-rata pretest, artinya pemahaman peserta meningkat mengenai Facebook Marketplace setelah diadakan sosialisasi literasi digital. Kegiatan ini diharapkan untuk meningkatkan penjualan dan jangkauan dari pemasaran produk UMKM.
Atuação política das Forças Armadas e o fenômeno bolsonarista no Brasil (2013-2022)
Authors: Araujo Rafael , Sales Jean 
Published: February 2024

Recebido: 13/05/2022
Aprovado: 02/06/2022
O artigo analisa a atuação política das Forças Armadas e suas relações com o bolsonarismo. Parte do pressuposto segundo o qual os militares tiveram papel protagonista no processo de abertura política, mas que sua atuação na política aumentou com a chegada de Jair Bolsonaro ao poder. O artigo finaliza realizando algumas reflexões sobre elementos do atual governo que permitem caracterizá-lo como sendo constituído por fortes traços fascistas.
Palavras-chaves: Forças Armadas; Bolsonarismo; Política; Fascismo.
Masculinidade personalista em “República dos assassinos”:
Authors: Santana Diniz Luciana Renata , Silveira Dantas Junior Hamilcar 
Published: February 2024

Recebido: 30/10/2021
Aprovado: 30/04/2022
As declarações misóginas do Presidente Jair Bolsonaro são publicizadas desde sua época de deputado federal. Hoje na Presidência, entendemos que suas ações estão fincadas em raízes violentas, que reproduzem uma lógica de ódio, masculinista e miliciana, já representada no cinema nacional. O objetivo deste artigo é refletir as origens dessa ordem masculinista personalista brasileira traçando paralelos entre a obra fílmica “República dos Assassinos” do diretor Miguel Faria Júnior (1979), as personagens circulantes da trama com as personalidades que fazem parte do atual governo bolsonarista. Objetivamos desnudar essas relações masculinistas personalistas e defender a tese de que o filme reflete (sem anacronismos) dados da nossa realidade presente. Para tanto, usamos as reflexões de Jacques Aumont e Julie Marie em uma análise temática do filme, percebendo os ecos de suas personagens “fictícias” nas manifestações performáticas próprias da masculinidade bolsonarista.
Palavras chaves: Masculinidade. Bolsonarismo. Memória. História. Cinema.
pandemia de COVID-19 e seus impactos sobre a docência do ensino superior
Authors: Pereira de Souza Alessa Cristina , Lima Sousa de Carvalho Anne Gabriele 
Published: February 2024

Recebido: 10/11/2022
Aprovado: 15/04/2023
Este artigo analisa os principais impactos dos dois primeiros anos da pandemia sobre as atividades na docência do ensino superior do nordeste do Brasil. O trabalho foi subsidiado por um levantamento, via formulário digital, alcançando 799 docentes. Os resultados indicam o aumento no tempo de dedicação às atividades, levando à precarização da docência e prejuízos em diferentes dimensões da vida. Os dados apresentam desafios institucionais para o acolhimento necessário à readaptação das atividades após um período permeado por tensões diversas.
Palavras-chave: Trabalho remoto; Docentes; Precarização da vida.
Selected osteointegration markers in different timeframes after dental implantation: findings and prognostic value
Authors: Bayandurov Emir , Orjonikidze Zurab , Kraveishvili Sophio , Orjonikidze Ramaz , Ormotsadze George , Kalmakhelidze Sophio , Sanikidze Tamar 
Published: February 2024

The study aimed to determine the osteointegration markers after dental implantation and evaluate their predictive value. The study was performed on 60 practically healthy persons who needed teeth rehabilitation using dental implants. The conical-shaped implants (CI) and hexagonal implants (HI) were used. The content of Osteopontin (OPN), Osteocalcin (OC), Alkaline Phosphatase (ALP), Osteoprotegerin (OPG), and nitric oxide (NO) was determined in patients’ gingival crevicular fluid (GCF) and peri-implant sulcular fluid (PISF), collected 1, 3, and 6 months after implantation. During the 3–6 months of observation level of OPN increased in patients with CIs (&lt;50 years &gt; 50 years) and HIs (&lt;50 years) (CI: &lt;50 years F = 36.457, p &lt; 0.001; &gt;50 years F = 30.104, p &lt; 0.001; HI &lt; 50 years F = 2.246, p &lt; 0.001), ALP increased in patients with CIs (&lt;50 years: F = 19.58, p &lt; 0.001; &gt;50 years: F = 12.01; p = 0.001) and HIs (&lt;50 years) (F = 18.51, p &lt; 0.001), OC increased in patients &lt;50 years (CI: F = 33.72, p &lt; 0.001; HI: F = 55.57, p &lt; 0.001), but in patients &gt;50 years - on the 3 days month (CI: F = 18.82, p &lt; 0.001; HI: F = 26.26, p &lt; 0.001), but sharply decreased at the end of sixth month. OPG increased during 1–3 months of the observation in patients &lt;50 years (CI: F = 4.63, p = 0.037; HI: F = 2.8927, p = 0.046), but at the end of the sixth month returned to the initial level; NO content in PISF increased in patients with CI (&gt;50 years) during 1–6 months of the observation (F = 27.657, p &lt; 0.001). During the post-implantation period, age-related differences in osteointegration were observed. Patients &lt;50 years old had relatively high levels of OPN, ALP, OC, and OPG in PISF, resulting in less alveolar bone destruction around dental implants and more intensive osteointegration. These indicators may be used as biological markers for monitoring implant healing. The process of osseointegration was more intense in CIs due to their comparatively high mechanical loading.
Glucocorticoid-induced osteoporosis is prevented by dietary prune in female mice
Authors: Chargo Nicholas J. , Neugebauer Kerri , Guzior Douglas V. , Quinn Robert A. , Parameswaran Narayanan , McCabe Laura R. 
Published: February 2024

Glucocorticoid-induced osteoporosis (GIO) is a significant side effect of prolonged glucocorticoid (GC) treatment. Chronic GC treatment also leads to trabecular bone loss and gut microbiota dysbiosis in mice. The gut dysbiosis is mechanistically linked to GIO, which indicates that the microbiota can be targeted to prevent GIO. Prunes, a dried fruit and prebiotic, have emerged in the literature as an effective treatment for sex-steroid deficiency induced osteoporosis (primary osteoporosis). Prunes also significantly alter the composition of the gut microbiota in both rodent models and human studies. Therefore, we tested if dietary prune (DP) supplementation could prevent GC-induced bone loss and affect microbiota composition in an established model of GIO. Sixteen-week-old, skeletally mature, female C57BL/6J mice were treated with a subcutaneous 5 mg placebo or prednisolone pellet for 8 weeks and fed an AIN-93M control diet or a diet modified to include 5, 15, or 25% (w/w) dried California prune powder. As expected, GC treated mice developed significant trabecular bone loss in the distal femur. More importantly, as little as 5% DP supplementation effectively prevented trabecular bone loss. Further, dose dependent increases in trabecular bone volume fraction were observed in GC + 15% and GC + 25% DP mice. Amazingly, in the placebo (non-GC treated) groups, 25% DP supplementation caused a ∼3-fold increase in distal femur trabecular bone volume fraction; this sizable bone response has not been previously observed in healthy mice with gut targeted natural treatments. Along with the striking effect on bone health, GC treatment and 25% DP supplementation led to drastic shifts in gut microbiota composition and several specific changes are strongly associated with bone health. Taken together, these results are the first to demonstrate that DP supplementation effectively prevents the negative effects of prolonged GC therapy on trabecular bone health and strongly associates with shifts in the composition of the gut microbiota.
The reality and obstacles of teaching Saudi Arabian Sign Language (SASL) to hearing students in regular schools: Alshams Private School as a model
Authors: Alamri Abdulhadi A. 
Published: February 2024

IntroductionThis study delves into the reality and challenges associated with teaching Saudi Arabian Sign Language (SASL) to hearing students within the context of regular schools.MethodsA descriptive survey methodology was employed, utilizing a researcher-developed questionnaire. The sample comprised 148 participants, including 94 male and 54 female fifth- and sixth-grade students from Alshams Private School in Riyadh, Saudi Arabia.ResultsThe investigation unveiled various obstacles in SASL instruction, encompassing the absence of Deaf sign language teachers, limited availability of diverse levels or courses for sign language education, occasional student embarrassment, and challenges related to the learning environment and resources. Gender-based differences were observed, with female students exhibiting a more positive outlook on the feasibility of SASL instruction. However, no gender-based distinctions were evident concerning perceived obstacles or overall questionnaire responses. Additionally, no significant differences emerged between fifth- and sixth-grade students in their perceptions of obstacles or questionnaire responses.DiscussionThe findings offer valuable insights into the challenges and student perceptions associated with SASL instruction in Saudi Arabian schools. Notably, the study provides a foundation for further research and potential improvements in sign language education.
Enhancing fuel cell performance through a dual MPC strategy for coordinated temperature management
Authors: Liu Lidong , Zhang Mengli , Gong Jianjun 
Published: February 2024

Ensuring the optimal operating temperature is imperative for achieving efficient performance in proton exchange membrane fuel cells. Consequently, this study introduces a dual-model predictive control strategy to regulate the water pump and cooling fan in a cooling system. Initially, we establish an electrochemical and thermal model for fuel cell stacks and validate the model’s accuracy through experimental data. The system model is linearized, and the model predictive control (MPC) controller is formulated using the MATLAB/Simulink toolbox. Subsequently, it is collaboratively simulated with the electrochemical model of the fuel cell stack and the temperature model. To evaluate the effectiveness of the MPC controller, we conducted a comparative analysis with the traditional proportional–integral–derivative (PID) control and water pump MPC under step load, uniform load increase, and variable target scenarios. The findings indicate that in contrast to the PID control, the MPC controller significantly decreases the stack temperature difference fluctuation by more than 50%, maintaining the stack temperature within ±0.6 K of the set value. Furthermore, we independently assessed the performance of the MPC controller under varying ambient temperatures. The findings illustrate that the dual MPC method proficiently adapts cooling parameters across different ambient temperature ranges (288.15 K–308.15 K), ensuring the stable performance of the fuel cell. The model is linearized, and the simulation work is explained mainly on the MATLAB/Simulink platform. In order to compare the effectiveness of the MPC controller, the comparison with the MPC controller strategy of the water pump is added, which can better reflect the effectiveness of the proposed collaborative MPC controller strategy.
Evaluating the potential footprints of land use and land cover and climate dynamics on atmospheric pollution in Pakistan
Authors: Dilawar Adil , Chen Baozhang , Ul-Haq Zia , Ali Shahbaz , Sajjad Meer Muhammad , Junjun Fang , Gemechu Twekel M. , Guo Man , Dilawar Hamza , Zhang Huifang , Zicheng Zheng , Lodhi Ehtisham 
Published: February 2024

Evaluating the potential impacts of land use and land cover change (LULCC) and climate change on air pollution is crucial to unravel the driving forces and mechanisms behind changes in air quality. A multi-faceted approach was adopted, including a land change model (LCM) and Mann–Kendall (MK) test, to evaluate the transition of land cover type, changes in climate, and atmospheric pollutants during 2004–2021 in Pakistan. Moreover, a multiscale geographically weighted regression (MGWR) model and a mathematical model were used to assess the potential contribution of LULCC and climate dynamics to atmospheric pollution. It was revealed that during 2004, croplands covered an area of 9.72 × 104 mile2, accounting for 38% of the total area. However, the area of the croplands increased to 10.1 × 104 mile2, accounting for 40% of the total area in 2021. The MK test showed that the north and west–south regions significantly experienced air pollution, with the increasing trend for nitrogen dioxide (NO2) and sulfur dioxide (SO2) being 0.89× 1015 molecules/cm2 per year and 0.54 DU/year, respectively. For climate variability, mean precipitation (Precp) and mean surface pressure (SP) showed a prominent increasing trend, with a maximum value of 1 mm/year and 0.01 Kpa/year, respectively. The mean temperature maximum (Tmax) showed an increasing and decreasing trend, with the highest value of 0.28°C/year and 0.08°C/year, respectively. In the context of contribution, the conversion of cropland to grasslands increased the trend for SO2 concentrations. The highest increasing trend of 1.5 DU for ozone (O3) was found due to conversion of grasslands to shrublands. Additionally, regional climate played a significant role in making air pollution stagnant across the country. Precp and wind speed (WS) contributed significantly in escalating NO2 concentrations in Pakistan, while Precp contributed most (0.004 DU) to increasing SO2 concentrations. For O3, the most influential climate factor was Precp. These results on a long-term temporal scale demonstrated how maintaining climate variability through comprehensive land use management can help improve ambient air quality in Pakistan.
Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer
Authors: Zhu Hehuan , Roelands Jessica , Ahmed Eiman I. , Stouten Imke , Hoorntje Rachel , van Vlierberghe Ronald L. P. , Ijsselsteijn Marieke E. , Lei Xin , de Miranda Noel F. C. C. , Tollenaar Rob A. E. M. , Vahrmeijer Alexander L. , Bedognetti Davide , Hendrickx Wouter R. L. , Kuppen Peter J. K. 
Published: February 2024

BackgroundColon cancer is a heterogeneous disease and consists of various molecular subtypes. Despite advances in high-throughput expression profiling, limitations remain in predicting clinical outcome and assigning specific treatment to individual cases. Tumor-immune interactions play a critical role, with tumors that activate the immune system having better outcome for the patient. The localization of T cells within tumor epithelium, to enable direct contact, is essential for antitumor function, but bulk DNA/RNA sequencing data lacks spatial distribution information. In this study, we provide spatial T cell tumor distribution and connect these data with previously determined genomic data in the AC-ICAM colon cancer patient cohort.MethodsColon cancer patients (n=90) with transcriptome data available were selected. We used a custom multiplex immunofluorescence assay on colon tumor tissue sections for quantifying T cell subsets spatial distribution in the tumor microenvironment, in terms of cell number, location, mutual distance, and distance to tumor cells. Statistical analyses included the previously determined Immunologic Constant of Rejection (ICR) transcriptome correlation and patient survival, revealing potential prognostic value in T cell spatial distribution.ResultsT cell phenotypes were characterized and CD3+CD8-FoxP3- T cells were found to be the predominant tumor-infiltrating subtype while CD3+FoxP3+ T cells and CD3+CD8+ T cells showed similar densities. Spatial distribution analysis elucidated that proliferative T cells, characterized by Ki67 expression, and Granzyme B-expressing T cells were predominantly located within the tumor epithelium. We demonstrated an increase in immune cell density and a decrease in the distance of CD3+CD8+ T cells to the nearest tumor cell, in the immune active, ICR High, immune subtypes. Higher densities of stromal CD3+FoxP3+ T cells showed enhanced survival outcomes, and patients exhibited superior clinical benefits when greater spatial distances were observed between CD3+CD8-FoxP3- or CD3+CD8+ T cells and CD3+FoxP3+ T cells.ConclusionOur study’s in-depth analysis of the spatial distribution and densities of major T cell subtypes within the tumor microenvironment has provided valuable information that paves the way for further research into the intricate relationships between immune cells and colon cancer development.
Case report: The utilization of crizotinib and brentuximab vedotin as a bridge to autologous stem cell transplantation and followed by CD30-directed CAR-T cell therapy in relapsed/refractory ALK+ ALCL
Authors: Liu Wanying , Wu Jiaying , Ming Xi , Zhang Qi , Zhou Delian , Zheng Rubing , Zhou Mi , Shang Zhen , Chen Liting , Zhu Xiaojian , Xiao Yi 
Published: February 2024

BackgroundAnaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ ALCL) is a rare, mature T-cell non-Hodgkin lymphoma. The prognosis of patients with relapsed or refractory ALCL following first-line chemotherapy is extremely poor. NCCN guidelines recommend intensified chemotherapy with or without ASCT consolidation for r/r ALCL, however, this is not an effective treatment for all ALK+ALCL.Case reportHerein, we report a patient with relapsed/refractory ALK+ ALCL who received crizotinib and brentuximab vedotin as bridging therapy, followed by autologous stem cell transplantation and sequential anti-CD30 CAR T cell therapy.ConclusionThe patient achieved complete remission and long-term disease-free survival of months and continues to be followed up. The combination therapy model in this case may provide guidance for the management of relapsed/refractory ALK+ ALCL, and further prospective trials are needed to confirm its effectiveness.
Comparing different lymphatic filariasis patient estimate approaches and results in Ethiopia
Authors: Mengistu Belete , Kebede Fikreab , Negash Biruck Kebede , Miheret Addisalem , Beyene Biruk Kebede , Abetew Solomon , Tedla Berihu Gebremariam , Oucha Asfaw Kejella , Alene Shigute , Backers Sharone , Burgert Clara , Toubali Emily , Brady Molly , McPherson Scott 
Published: February 2024

BackgroundThe World Health Organization (WHO) recommends that countries ensure morbidity management and disability prevention (MMDP) services are available to all lymphedema and hydrocele patients in lymphatic filariasis (LF)-endemic areas. The first step in ensuring the availability of MMDP services is to understand the number and distribution of people with lymphedema and hydrocele. We examined the burden of lymphoedema and hydrocoele using different patient estimation approaches employed in endemic districts of the Beneshangul-Gumuz and Tigray regions of Ethiopia.Methodology/principal findingsIn Approach I, trained health extension workers (HEWs) conducted the patient estimates during a door-to-door pre-mass drug administration (MDA) census. Validation of a sample of the data collected was integrated with a post-MDA coverage survey. In Approach II, trained HEWs conducted a stand-alone patient estimation, and clinical officers validated all suspected patients. In 15 districts, 753,557 individuals were surveyed. A total of 1,645 lymphedema (1:1.6 male-to-female ratio) and 517 hydrocele cases were identified. The prevalence of lymphedema and hydrocele was 40 per 10,000 in the adult population and 25 per 10,000 in the adult male population, with wide variation across districts. Validation in Approach I showed that 94% of the lymphedema cases and 77% of hydrocele cases were correctly identified by the HEWs, while 60% and 53% were correctly identified in Approach II.Conclusion/significancePatient estimation is important for planning, prioritization, targeting interventions, and monitoring progress in LF-endemic areas. Trained HEWs can correctly identify most cases using a standardized patient estimate job aid and questionnaire, even when cascade training is used. For the purposes of LF elimination, these results are sufficient and at a low cost per district. Ethiopia’s LF program could integrate patient estimations into MDA activities in the remaining LF-endemic districts with minimal cost and effort.
Bibliometric and scientometric analysis on biomarkers and molecular mechanisms for physical frailty and sarcopenia
Authors: Ginevičienė Valentina , Pranckevičienė Erinija , Kilaitė Justina , Mastavičiūtė Asta , Dadelienė Rūta , Jamontaitė Ieva Eglė , Letukienė Austėja , Ahmetov Ildus I. , Alekna Vidmantas 
Published: February 2024

IntroductionThe influence of physical frailty and sarcopenia (PFS) on the well-being of older people and continuous pressure on the healthcare systems has prompted a research on the pathophysiology and molecular mechanisms of these conditions. Nonetheless some biomarkers have been suggested as potential markers for PFS none of them have been shown to highlight the complex nature of PFS, which reveals that there is a need for an understanding of the possible biomarker candidates. The aim of this study was to identify the current research hotspots, status, and trends in the field of biomarkers and molecular mechanisms for PFS.MethodsThe bibliometric and scientometric analyses were performed using VOSviewer (version 1.6.18) and open source software platform Cytoscape v.3.9 (for visualizing and constructing a network of keywords). Data of publications (from 1997 to 2023) related to biomarkers and molecular mechanisms of PFS were obtained (in May 2023) from the database of Science Citation Index Expanded of Web of Science, Scopus, and PubMed. The keywords obtained from the Scopus database were used to perform a meaningful keyword analysis. A network of keyword relationships was build using Cytoscape.ResultsIn this study, we present biomarker keywords for PFS in relation to other keywords potentially designating processes and mechanisms and reveal the biomarker identities and current contexts in which these biomarker identities are discussed.ConclusionsOver recent years, scientific interest in the field of PFS has increased and focused on the inflammatory process and probably will be concentrated on myokines (such as cytokines and small proteins) that are synthetized and released by skeletal muscles in response to physical activity. Moreover, proteomic and genetic markers are deeply involved in PFS.