bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered Glucagon and GLP-1 Responses to Oral Glucose in Children and Adolescents With Obesity and Insulin Resistance
Authors: Stinson Sara Elizabeth , Fernández de Retana Alzola Ierai , Brünner Hovendal Emilie Damgaard , Lund Morten Asp Vonsild , Fonvig Cilius Esmann , Holm Louise Aas , Jonsson Anna Elisabet , Frithioff-Bøjsøe Christine , Christiansen Michael , Pedersen Oluf , Ängquist Lars , Sørensen Thorkild I A , Holst Jens Juul , Hartmann Bolette , Holm Jens-Christian , Hansen Torben 
Published: December 2023

Abstract

Context
Pediatric obesity is characterized by insulin resistance, yet it remains unclear whether insulin resistance contributes to abnormalities in glucagon and incretin secretion.

Objective
To examine whether fasting and stimulated glucagon, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) concentrations differ between children and adolescents with obesity and insulin resistance (OIR), obesity and normal insulin sensitivity (OIS), and controls with normal weight (NW).

Methods
80 (34 boys) children and adolescents, aged 7-17 years with OIR (n = 22), OIS (n = 22), and NW (n = 36) underwent an oral glucose tolerance test with measurements of serum insulin, plasma glucose, glucagon, total GLP-1, and total GIP. Homeostatic model assessment of insulin resistance (HOMA-IR), single point insulin sensitivity estimator (SPISE), Matsuda index, insulinogenic index (IGI), and oral disposition index (ODI) were calculated.

Results
Fasting concentrations of glucagon and GLP-1 were higher in the OIR group, with no significant differences for GIP. The OIR group had higher glucagon total area under the curve (tAUC0-120) and lower GLP-1 incremental AUC (iAUC0-120), with no significant differences in GIP iAUC0-120. Higher fasting glucagon was associated with higher HOMA-IR, lower Matsuda index, lower SPISE, higher IGI, and higher plasma alanine transaminase, whereas higher fasting GLP-1 was associated with higher HOMA-IR, lower Matsuda index, and lower ODI. Higher glucagon tAUC0-120 was associated lower SPISE and lower Matsuda index, whereas lower GLP-1 iAUC0-120 was associated with a higher HOMA-IR, lower Matsuda index, and lower ODI.

Conclusion
Children and adolescents with OIR have elevated fasting concentrations of glucagon and GLP-1, higher glucagon and lower GLP-1 responses during an OGTT compared to those with OIS and NW. In contrast, individuals with OIS have similar hormone responses to those with NW.
Residual In-Stent Carotid Stenosis and Cigarette Smoking are Independent Predictors of Carotid Restenosis After Carotid Artery Stenting—Results from 738 Carotid Artery Stenting Procedures at a Single Center
Authors: Lai Pui Man Rosalind , Baig Ammad A. , Khawar Wasiq I. , Kruk Marissa D. , Donnelly Brianna M. , Siddiqi Manhal , Davies Jason M. , Siddiqui Adnan H. , Snyder Kenneth V. , Levy Elad I. 
Published: December 2023

BACKGROUND AND OBJECTIVES:
Carotid artery stenting (CAS) has become a viable alternative to carotid endarterectomy for the management of carotid stenosis. Our aim was to determine the rate of radiographic restenosis after CAS and clinical, radiographic, and procedural predictors of in-stent restenosis.

METHODS:
Our single-center, prospectively maintained database was retrospectively reviewed for CAS procedures performed in symptomatic and asymptomatic patients over 12 years (2010-2022). Baseline demographic data, procedural characteristics, and preprocedural and postprocedural radiographic and clinical details were noted. Baseline characteristics of patients with and without carotid restenosis were compared using the χ2 test for categorical variables and the Student t-test for continuous variables. Univariate and multivariate analyses were performed to determine risk factors associated with restenosis, defined as >70% on digital subtraction angiography.

RESULTS:
A total of 1017 consecutive CAS procedures were performed in 905 patients during the 12-year period, with 738 in 632 patients included in our study. Our cohort's overall restenosis rate was 17%, with a 14% restenosis rate at 2 years. On multivariate regression analysis, former or current smoking status (odds ratio [OR] = 2.3, 95% CI 1.2-4.1), plaque irregularity (OR 0.55, 95% CI 0.33-0.91), moderate (50.1%-75%) contralateral stenosis (OR 3.2, 95% CI 1.4-7.2), severe (75.1%-99.9%) contralateral stenosis (OR 2.8, 95% CI 1.3-6.0), and residual (>70%) in-stent stenosis after initial stenting (OR 433, 95% CI 80-2346) were significantly associated with carotid restenosis. Area under the curve for the multivariate regression model analysis was 0.78. Patients with <28.6% initial (residual) in-stent stenosis (45/517 cases) had a 9% restenosis rate, whereas those with >28.6% initial in-stent stenosis (77/221 cases) had a 35% restenosis rate.

CONCLUSION:
In this large, single-center study of carotid artery stenosis treated with CAS, residual in-stent carotid stenosis of approximately 30% and smoking status were independent predictors for restenosis. Maximizing treatment of initial stenosis and smoking cessation education are important steps in preventing future carotid restenosis.
Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility
Authors: Ding Yuxi , He Zequn , Sha Yanwei , Kee Kehkooi , Li Lin 
Published: December 2023

ABSTRACT
Infertility affects couples worldwide. Premature ovarian insufficiency (POI) refers to loss of ovarian function before 40 years of age and is a contributing factor to infertility. Several case studies have reported dominant-inherited POI symptoms in families with heterozygous EIF4ENIF1 (4E-T) mutations. However, the effects of EIF4ENIF1 haploinsufficiency have rarely been studied in animal models to reveal the underlying molecular changes related to infertility. Here, we demonstrate that Eif4enif1 haploinsufficiency causes mouse subfertility, impairs oocyte maturation and partially arrests early embryonic development. Using dual-omic sequencing, we observed that Eif4enif1 haploinsufficiency significantly altered both transcriptome and translatome in mouse oocytes, by which we further revealed oocyte mitochondrial hyperfusion and mitochondria-associated ribonucleoprotein domain distribution alteration in Eif4enif1-deficient oocytes. This study provides new insights into the molecular mechanisms underlying clinical fertility failure and new avenues to pursue new therapeutic targets to address infertility.
BilevelJuMP.jl: Modeling and Solving Bilevel Optimization Problems in Julia
Authors: Garcia Joaquim Dias , Bodin Guilherme , Street Alexandre 
Published: December 2023

In this paper, we present BilevelJuMP.jl, a new Julia package to support bilevel optimization within the JuMP framework. The package is a Julia library that enables the user to describe both upper and lower-level optimization problems using the JuMP algebraic syntax. Because of the generality and flexibility that our library inherits from JuMP’s syntax, our package allows users to model bilevel optimization problems with conic constraints in the lower level and all constraints supported by JuMP in the upper level including conic, quadratic, and nonlinear constraints. Moreover, the models defined with the syntax from BilevelJuMP.jl can be solved by multiple techniques that are based on reformulations as mathematical programs with equilibrium constraints (MPEC). Manipulations on the original problem data are possible due to MathOptInterface.jl’s structures and Dualization.jl features. Hence, the proposed package allows quick modeling, deployment, and thereby experimenting with bilevel models based on off-the-shelf mixed-integer linear programming and nonlinear solvers. History: Accepted by Ted Ralphs, Area Editor for Software Tools. Funding: The authors were partially supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. The work of A. Street was also partially supported by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). The work was partially funded by the project P&D ANEEL PD-00403-0050/2020 sponsored by ENGIE BRASIL ENERGIA S.A. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0135 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0135 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Use and Future Development of Optical Measurement Technology in the Study of Wood Surface Roughness CiteSpace-Based Scientometric Analysis (2003 through 2022)
Authors: Jia Na , Shi Wendi , Guo Lei , Liu Jiuqing 
Published: December 2023

Abstract
Although the contact probe measurement technique is excellent for wood surface roughness measurement, it is necessary to reevaluate the advantages and future development direction of optical measurement techniques in this field, given the emergence of optical measurement techniques such as laser technology and the increasing academic interest in wood surface roughness. The traditional review method, due to its rather limited research directions, only provides a macroscopic and qualitative description of certain laws and conclusions. The purpose of this review is to use the bibliometrics theory and method to comprehensively sort out the research hot spots in this field and explore them in depth.
Acceptability and appropriateness of a risk-tailored organised melanoma screening program: Qualitative interviews with key informants
Authors: Dunlop Kate L. A. , Keogh Louise A. , Smith Andrea L. , Aranda Sanchia , Aitken Joanne , Watts Caroline G. , Smit Amelia K. , Janda Monika , Mann Graham J. , Cust Anne E. , Rankin Nicole M. 
Published: December 2023

IntroductionIn Australia, opportunistic screening (occurring as skin checks) for the early detection of melanoma is common, and overdiagnosis is a recognised concern. Risk-tailored cancer screening is an approach to cancer control that aims to provide personalised screening tailored to individual risk. This study aimed to explore the views of key informants in Australia on the acceptability and appropriateness of risk-tailored organised screening for melanoma, and to identify barriers, facilitators and strategies to inform potential future implementation. Acceptability and appropriateness are crucial, as successful implementation will require a change of practice for clinicians and consumers.MethodsThis was a qualitative study using semi-structured interviews. Key informants were purposively selected to ensure expertise in melanoma early detection and screening, prioritising senior or executive perspectives. Consumers were expert representatives. Data were analysed deductively using the Tailored Implementation for Chronic Diseases (TICD) checklist.ResultsThirty-six participants were interviewed (10 policy makers; 9 consumers; 10 health professionals; 7 researchers). Key informants perceived risk-tailored screening for melanoma to be acceptable and appropriate in principle. Barriers to implementation included lack of trial data, reluctance for low-risk groups to not screen, variable skill level in general practice, differing views on who to conduct screening tests, confusing public health messaging, and competing health costs. Key facilitators included the perceived opportunity to improve health equity and the potential cost-effectiveness of a risk-tailored screening approach. A range of implementation strategies were identified including strengthening the evidence for cost-effectiveness, engaging stakeholders, developing pathways for people at low risk, evaluating different risk assessment criteria and screening delivery models and targeted public messaging.ConclusionKey informants were supportive in principle of risk-tailored melanoma screening, highlighting important next steps. Considerations around risk assessment, policy and modelling the costs of current verses future approaches will help inform possible future implementation of risk-tailored population screening for melanoma.
Prevalence of dry eye during the COVID-19 pandemic: A systematic review and meta-analysis
Authors: Ji Haiyang , Yang Yun , Lu Yunqiong , Kong Xiehe , Yang Guang , Liu Jie , Yang Yanting , Wang Xuejun , Ma Xiaopeng 
Published: December 2023

ObjectiveDuring the COVID-19 pandemic, many people devoted longer time to screen viewing due to the need for study, work, and online social activities, instead of outdoor activities, which may have led to an increase in dry eye symptoms. This study aimed to evaluate the prevalence of dry eye during the COVID-19 pandemic.MethodsPubMed, Cochrane Library, Embase, and Web of Science were searched from January 1, 2020 to October 20, 2022. Cross-sectional surveys on dry eye prevalence conducted after January 1, 2020 were included. Two review authors independently performed data extraction and assessed study quality. The random-effects model was used to analyze the prevalence of dry eye, and the odds ratio was used to assess the strength of the association between variables. Subgroup analysis was performed to detect heterogeneity, the leave-one-out method for sensitivity analysis, and the Egger test for publication bias.ResultsA total of eleven studies with 15692 individuals met the eligibility criteria. The prevalence of dry eye during the COVID-19 pandemic was 61.0% (95%CI: 51.8%-70.2%) globally and 56.7% (95%CI: 45.3%-68.1%) in Asia. The prevalence of dry eye had significant differences in sex and visual display time, with higher prevalence among females and visual display time of more than 4 hours per day. Subgroup analysis was performed based on diagnostic tools, study population, and average age. A significant difference was found in diagnostic tools, but no significant change in heterogeneity (P<0.05). The leave-one-out method showed stable results, and the Egger test identified no significant publication bias.ConclusionThe prevalence of dry eye during the COVID-19 pandemic is significantly higher than before, and a higher prevalence is found among females and those having a visual display time of more than 4 hours per day.
What works in engaging communities? Prioritising nutrition interventions in Burkina Faso, Ghana and South Africa
Authors: Watson Daniella , Barker Mary , Boua P. Romuald , Chatio Samuel , Compaoré Adelaide , Danis Marion , Dalaba Maxwell , Erzse Agnes , Hardy-Johnson Polly , Kehoe Sarah H. , Hofman Karen J. , Lawrence Wendy T. , Nonterah Engelbert A. , Sorgho Hermann , Rwafa-Ponela Teurai , Ward Kate A. , Tugendhaft Aviva ,   on behalf of the INPreP study group
Published: December 2023

Background
“Choosing All Together” (CHAT), is a community engagement tool designed to give the public a voice in how best to allocate limited resources to improve population health. This process evaluation explored the mechanisms through which CHAT generates community engagement.

Method
The CHAT tool was adapted and implemented for use in two rural communities (Nanoro, Burkina Faso, and Navrongo, Ghana) and one urban township (Soweto, South Africa) to prioritize maternal and child nutrition interventions. Community discussions were audio-recorded, transcribed, and translated into English. Twenty-two transcripts, including six each from Navrongo and Soweto and 10 from Nanoro, were analysed thematically to generate data driven codes and themes to explain mechanisms underlying the CHAT process. The process evaluation was based on the UK MRC process evaluation guidance.

Results
Seven themes describing the functions and outcomes of CHAT were identified. Themes described participants deliberating trade-offs, working together, agreeing on priorities, having a shared vision, and increasing their knowledge, also the skills of the facilitator, and a process of power sharing between participants and researchers. Participants came to an agreement of priorities when they had a shared vision. Trained facilitators are important to facilitate meaningful discussion between participants and those with lower levels of literacy to participate fully.

Conclusion
CHAT has been shown to be adaptable and useful in prioritising maternal and child nutrition interventions in communities in Burkina Faso, Ghana, and South Africa. Conducting CHAT in communities over a longer period and involving policy-makers would increase trust, mutual respect and develop partnerships.
Not Your Typical Hyperammonemia: Non-hepatic Severe Hyperammonemia in an Adult
Authors: Barnhill Michele , Yaman Reena , Renszel Krystal , Alzubaidi Sadeer , Vargas Hugo , Chascsa David 
Published: December 2023

ABSTRACT
Hyperammonemia in adults is most often due to cirrhosis. Ammonia is metabolized through the urea cycle. With liver disease, this pathway is altered, and urea is unable to be formed, creating a buildup of ammonia with numerous side effects, including encephalopathy. A less common presentation is hyperammonemia in the absence of liver disease. We present a rare case of non-cirrhotic hyperammonemia due to a splenogonadal shunt.
WATS3D: An Interobserver Study of Barrett's Esophagus–Associated Dysplasia Among Gastrointestinal Pathologists
Authors: Patil Deepa T. , Goldblum John R. , Lauwers Gregory , Lewis Jason T. , Robert Marie , Singer Mendel , Odze Robert D. 
Published: December 2023

INTRODUCTION:
Wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS3D) has been shown to increase the detection rate of dysplasia (and intestinal metaplasia) in patients with Barrett's esophagus (BE). The purpose of this study was to evaluate the interobserver variability and accuracy of diagnosing BE-associated dysplasia in WATS3D specimens among gastrointestinal (GI) pathologists without prior experience with this technology.

METHODS:
Five GI pathologists underwent a 4-hour in-person (at microscope) and virtual training session and then evaluated digital images of discrete cellular foci from 60 WATS3D cases with BE (20 nondysplastic BE [NDBE], 20 low-grade dysplasia [LGD], and 20 high-grade dysplasia/esophageal adenocarcinoma [HGD/EAC]). Each case consisted of 1 hematoxylin and eosin–stained image (cell block), and 1 liquid cytology or papanicolaou-stained smear image (120 images in total).

RESULTS:
The overall kappa value among the 5 study pathologists was excellent (overall kappa = 0.93; kappa = 0.93 and 0.97 for cell block and smear specimens, respectively). There were no significant differences noted in kappa values in interpretation of the cell block vs smear specimens or in any of the individual diagnostic categories when the latter were evaluated separately. Furthermore, agreement was perfect (100%) regarding detection of neoplasia (either LGD, HGD, or EAC). Diagnoses were made with complete confidence in 91% of instances.

DISCUSSION:
We conclude that GI pathologists, without any prior experience in interpretation of WATS3D specimens, can undergo a short training session and then diagnose these specimens with a very high level of accuracy and reproducibility.
Cooling‐promoted myogenic differentiation of murine bone marrow mesenchymal stem cells through TRPM8 activation in vitro
Authors: Takagi Ryo , Takegaki Junya , Osana Shion , Kano Yutaka , Konishi Satoshi , Fujita Satoshi 
Published: December 2023

AbstractTRPM8 agonist has been reported to promote osteogenic differentiation of mesenchymal stem cells (MSCs), therefore we evaluated whether cooling‐induced activation of TRPM8 promotes myogenic differentiation of MSCs. We used 5‐azacytidine as a myogenic differentiation inducer in murine bone marrow‐derived MSCs. Addition of menthol, a TRPM8 agonist, to the differentiation induction medium significantly, increased the percentage of MyoD‐positive cells, a specific marker of myogenic differentiation. We performed intracellular Ca2+ imaging experiments using fura‐2 to confirm TRPM8 activation by cooling stimulation. The results confirmed that intracellular Ca2+ concentration ([Ca2+]i) increases due to TRPM8 activation, and TRPM8 antagonist inhibits increase in [Ca2+]i at medium temperatures below 19°C. We also examined the effect of cooling exposure time on myogenic differentiation of MSCs using an external cooling stimulus set at 17°C. The results showed that 60 min of cooling had an acceleratory effect on differentiation (2.18 ± 0.27 times). We observed that the TRPM8 antagonist counteracted the differentiation‐promoting effect of the cooling. These results suggest that TRPM8 might modulate the multiple differentiation pathways of MSCs, and that cooling is an effective way of activating TRPM8, which regulates MSCs differentiation in vitro.
Supreme Audit Institution Recommendations and the Legal System: The Case of Indonesia
Authors: Atmaja A. P. Edi , Erliyana Anna , Simatupang Dian Puji N. , Oppusunggu Yu Un 
Published: December 2023

Abstract
The audit recommendations of the Indonesian supreme audit institution (Badan Pemeriksa Keuangan, BPK) acquired new significance after the collapse of the authoritarian state in 1998 and constitutional amendments in 1999–2002 that reformed the regulation and institutional governance of public sector audit in Indonesia. However, while the reform of public sector audit regulation was carried out through a strong adoption of private sector audit standards and the Westminster SAI model, the BPK retained some of its Napoleonic legacy. This syncretic organisation led to confusion about the BPK’s role and position in the Indonesian legal system. Using a historical and case study approach, this paper analyses the relationship between the BPK’s audit recommendations and the Indonesian legal system. It argues that it is important for the BPK to develop auditing standards that take full account of higher rules, administrative law, and national interests, or at least not to adopt and abolish auditing standards that are counterproductive to its judicial function – not merely to accommodate private international law instruments developed by private non-state actors operating outside the legal framework of a sovereign state.
Research progress on the effect of cooking and freezing processes on the quality of frozen dough steamed buns
Authors: Zhang Siyu , Yang Lina , Nie Yuchang , Liu He , Zhu Danshi 
Published: December 2023

Abstract
Owing to the convenient and rapid process of producing frozen dough steamed buns, it is rapidly gaining popularity in the Chinese market. However, frozen dough steamed bun products have several issues, such as volume reduction, flavour changes and digestion-related issues, owing to limitations in technology and craft. The quality of frozen dough steamed buns has improved consistently in recent years, and several manufacturers have focused on front-end processes, such as selection of raw and supplementary materials and application of ameliorants. This review summarises and expounds on the effects of steaming, freezing and reheating on the quality of frozen dough steamed buns, providing a reference for the exploration and improvement of technologies for producing frozen dough steamed buns in the future.