bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of topical ketorolac tromethamine on tear parameters, meibography, goblet cell density, and conjunctival oxidative stress in healthy dogs
Authors: Sonego Dábila Araújo , Ribeiro Alexandre Pinto , Dower Nathalie Moro Bassil , Rodrigues Bianca Eidt , de França Lemes Suélem Aparecida , de Oliveira Souza Anderson , de Lara Spada Elaine Cristina , Furlan Fernando Henrrique , Lisboa Douglas Ramalho , Rondon e Silva Jadyellen 
Published: December 2023

AbstractObjectivesThe objective of the study was to evaluate whether a twice‐daily instillation of 0.45% preservative‐free ketorolac tromethamine (FKT) or 0.4% benzalkonium chloride‐preserved ketorolac tromethamine (BACKT), every 12 h for 30 days may affect tear film parameters and the meibography in healthy dogs. Additionally, we assessed whether the same treatments irritated the ocular surface, affected goblet cell density (GCD), and the levels of oxidative stress biomarkers (OSB) in the conjunctiva of the same dogs.ProceduresExperimental and masked comparison study. In 11 healthy dogs baseline values of the lipid layer thickness, tear meniscus height, non‐invasive tear breakup time (NI‐TFBT), and the meibomian gland (MG) loss were assessed by OSAvet®. For each dog, one eye received 40 μL of BACKT, while the other received 40 μL FKT, every 12 h for 30 consecutive days. Tear parameters and meibography were repeated 15, 30, and 60 days post‐treatments. Conjunctival hyperemia and blepharospasm were monitored at the same time points. At baseline and Day 30, a conjunctival biopsy was collected for GCD and OSB determination.ResultsConjunctival hyperemia and blepharospasm were not observed. At Day 15, the MG loss increased only in FKT‐treated eyes (p < .001). On Day 30, both treatment groups showed increased MG loss, shortened NI‐TFBT, and reduced GCD and catalase (p < .05). At Day 30, BACKT‐treated eyes showed lower levels of superoxide dismutase (SOD) (p = .006) and higher levels of malondialdehyde (MDA) (p = .02). Differences between treatments were not observed for any parameter at any time point (p > .05). 60 days after treatment, OSAvet® parameters tended to return to values assessed at baseline; however, significant differences remained for MG loss (p < .05).ConclusionsTwice‐daily instillation of KT, containing or not BAC, for 30 consecutive days shortened NI‐TFBT, decreased GCD, and increased the MG loss in healthy dogs. KT should be used with caution when prescribed for long periods, particularly in patients with tear film abnormalities. However, future controlled studies using KT, BAC, and other topical NSAIDs are indicated to further support this finding.
Leveraging museum specimens, genomics and legacy datasets to unravel the phylogeny and biogeography of cryptin wasps (Hymenoptera, Ichneumonidae, Cryptini)
Authors: Santos Bernardo F. , Brady Seán G. 
Published: December 2023

AbstractModern genomic techniques have enabled the generation of phylogenetic datasets of unprecedented scale. However, there are also troves of molecular data accumulated from past studies using Sanger sequencing, often at fine taxonomic scales. Combining both sources of data is an obviously appealing possibility, but it can also lead to inconsistency due to high levels of missing data, disparities in the scale of Sanger versus genomic datasets, and little overlap in sequences across terminals. To provide an empirical investigation of the potential of such ‘hybrid’ datasets, we combined data from ultraconserved elements (UCEs) for 183 species of Cryptini (Ichneumonidae, Hymenoptera) with a previously existing dataset of 7 loci and morphological data including 308 species plus outgroup taxa. Bioinformatics pipelines allowed recovery of ‘legacy’ markers from the bycatch of UCE sequencing, reducing the problem of limited character overlap. The resulting tree combining Sanger and UCE data is highly supported and includes dense taxon sampling of the group, allowing for a better understanding of the global radiation of Cryptini. The Neotropical region had the highest phylogenetic diversity but the lowest level of phylogenetic dispersion when corrected for standardized effect size, while the Oriental fauna showed the highest level of phylogenetic dispersion. Our results highlight the potential of hybrid datasets to produce a more complete picture of the Tree of Life combining affordability, robust support and deep taxonomic sampling.
Right‐angled Artin groups as finite‐index subgroups of their outer automorphism groups
Authors: Wiedmer Manuel 
Published: December 2023

AbstractWe prove that every right‐angled Artin group occurs as a finite‐index subgroup of the outer automorphism group of another right‐angled Artin group. We furthermore show that the latter group can be chosen in such a way that the quotient is isomorphic to for some . For these, we give explicit constructions using the group of pure symmetric outer automorphisms. Moreover, we need two conditions by Day–Wade and Wade–Brück about when this group is a right‐angled Artin group and when it has finite index.
Study on the Burst Failure Mechanism and Residual Strength of Casing With Compound Wear Based on Extended Finite Element Method
Authors: Kuanhai Deng , Ming Zhang , Yang Peng , Niantao Zhou , Mingyuan Yao , Yuanhua Lin 
Published: December 2023

Abstract
Based on the data of wear casing for ShunNan 501 well in Northwest oilfield and the stress–strain intrinsic relationship of P110 tubing, a two-dimensional mechanical model of casing with compound wear is established by using the nonlinear extended finite element method (XFEM) and the burst failure criterion of damage evolution with due consideration of wear type, angle between crescents, overlap depth of crescents, and wear depth caused by drill pipe body and tool joint. The accuracy and reliability of model are verified by the full-scale burst test data. The effects of wear types, angle between crescents, overlap depth of crescents, and wear depth on the internal pressure yield strength (IPYS), burst strength and failure behavior for casing with compound wear are analyzed, by which it is found that casing with compound wear exist stress interference and complex interaction between stress interference and stress concentration, and the burst failure mechanism of casing with compound wear is revealed. Based on the gray correlation analysis result of wear parameters, a prediction model of the residual strength for P110 casing with compound wear is established by 1stOpt software and universal global optimization (UGO) algorithm.
Condition Monitoring of Wind Turbine Drivetrain Bearings
Authors: Gryllias Konstantinos , Qi Junyu , Mauricio Alexandre , Liu Chenyu 
Published: December 2023

Abstract
As an extremely valuable and reliable energy source, the renewable energy is developing around the world at an unprecedented pace. By the end of 2022, the global installed capacity of offshore wind turbines is expected to reach 46.4 GW, among which 33.9 GW in Europe. Efficiencies in Operations and Maintenance (O&M) offer potential to achieve significant cost savings as it accounts for around 20%–30% of overall offshore wind farm costs. A recent study of approximately 350 offshore wind turbines indicates that gearboxes might have to be replaced as early as 6.5 years. Therefore sensing and condition monitoring (CM) systems are needed in order to obtain reliable information on the state and condition of different critical parts. The development and use of such technologies will allow companies to schedule actions at the right time. The reduced costs of O&M enable the wind energy at a competitive price thus strengthening productivity of the wind energy sector. At the academic level, a plethora of methodologies have been proposed during the last decades focusing toward early and accurate fault detection. Among others, Envelope Analysis is one of the most important methodologies, where the envelope of the vibration signal is estimated, usually after filtering around a selected frequency band excited by impacts due to the faults. Different tools, such as Kurtogram, have been proposed in order to accurately select the optimum filter parameters (center frequency and bandwidth). Cyclostationary analysis and corresponding methodologies, i.e., the cyclic spectral correlation and the cyclic spectral coherence, have been proved as powerful tools for CM. On the other hand the application, test, and evaluation of such tools in general industrial cases is still rather limited. Therefore the main aim of this paper is the application and evaluation of advanced diagnostic techniques and diagnostic indicators, including the Enhanced Envelope Spectrum and the Spectral Flatness on real-world vibration data collected from vibration sensors on gearboxes in multiple wind turbines over an extended period of time of nearly four years. The diagnostic indicators are compared with classical statistic time and frequency indicators, i.e., Kurtosis, Crest Factor, etc. and their effectiveness is evaluated based on the successful detection of two failure events.
Menopausal status, age at menopause and risk of all-cause mortality among Chinese women: findings from a 10-year prospective study
Authors: Huang Sha , Gongye Ruofan , Zou Siyu , Hee Jia Yi , Tang Kun 
Published: December 2023

IntroductionMenopause characteristics (menopausal status and age at menopause) have been implicated in future health consequences. However, evidence of the impact on menopause on total mortality has been inconsistent. The present study aimed to investigate the associations of menopausal status and age at menopause with the risk of all-cause mortality in Chinese women.MethodsWe used prospective data from the China Kadoorie Biobank cohort study that recruited over 300 000 women aged 30–79 years from 10 regions across China between 2004 and 2008. All participants were prospectively followed up, with a median follow-up of 10.20 years. Cox proportional hazard regression was used to examine HRs with 95% CIs for all-cause mortality associated with menopausal status and age at menopause.ResultsCompared with premenopausal women, postmenopausal women were at higher risk of all-cause mortality with adjusted HR of 1.11 (95% CI 1.03 to 1.20). Among postmenopausal women, the HRs of total mortality were 1.25 (95% CI 1.14 to 1.36), 1.09 (95% CI 1.03 to 1.15), 0.98 (95% CI 0.94 to 1.02) and 0.97 (95% CI 0.91 to 1.04) for menopause at ages less than 40, 40–44, 50–53 and 54 years or older, respectively, relative to 45–49 years. In addition, for each 1-year increase in age at menopause was associated with a 1% decreased risk of death from all causes (95% CI 0.98 to 0.99).ConclusionsWomen with postmenopausal status had a higher risk of all-cause mortality than premenopausal women, particularly for ages at menopause younger than 45 years.
The effectiveness of brief non-pharmacological interventions in emergency departments and psychiatric inpatient units for people in crisis: A systematic review and narrative synthesis
Authors: Huber Jacqueline P , Milton Alyssa , Brewer Matthew C , Norrie Louisa M , Hartog Saskia M , Glozier Nick 
Published: December 2023

Objective: Heterogeneous brief non-pharmacological interventions and guidelines exist to treat the burgeoning presentations to both emergency department and inpatient settings, for those in a crisis of mental ill-health. We systematically reviewed the literature to create a taxonomy of these brief non-pharmacological interventions, and review their evaluation methods and effectiveness. Method: We conducted a systematic review across Cochrane, CINAHL, DARE, Embase, MEDLINE, PsycINFO databases. Studies meeting quality criteria, using Joanna Briggs Institute tools, were eligible. Interventions were categorised, and outcomes synthesised. Results: Thirty-nine studies were included: 8 randomised controlled trials, 17 quasi-experimental, 11 qualitative studies, and 3 file audits. Taxonomy produced six coherent intervention types: Skills-focussed, Environment-focussed, Special Observation, Psychoeducation, Multicomponent Group and Multicomponent Individual. Despite this, a broad and inconsistent range of outcome measures reflected different outcome priorities and prevented systematic comparison of different types of intervention or meta-analysis. Few brief non-pharmacological interventions had consistent evidential support: sensory modulation rooms consistently improved distress in inpatient settings. Short admissions may reduce suicide attempts and readmission, if accompanied by psychotherapy. Suicide-specific interventions in emergency departments may improve depressive symptoms, but not suicide attempt rates. There was evidence that brief non-pharmacological interventions did not reduce incidence of self-harm on inpatient wards. We found no evidence for frequently used interventions such as no-suicide contracting, special observation or inpatient self-harm interventions. Conclusion: Categorising brief non-pharmacological interventions is feasible, but an evidence base for many is severely limited if not missing. Even when there is evidence, the inconsistency in outcomes often precludes clinicians from making inferences, although some interventions show promise.
Development, Implementation, and Evaluation of Three Outreach Events to Improve COVID-19 Vaccine Uptake Among Racial and Ethnic Minority Communities in Houston, Texas, 2022
Authors: Munoz-Lavanderos Carmin , Oluyomi Abiodun , Rosales Omar , Hernandez Norvin , Mensah-Bonsu Nana , Badr Hoda 
Published: December 2023

Objectives: Lack of access to timely, accurate, and linguistically appropriate COVID-19 information has complicated the dissemination of evidence-based information and contributed to vaccine hesitancy among racial and ethnic minority groups in the United States. We developed community events that provided outreach, education, and access to COVID-19 vaccination to overcome vaccine hesitancy in these communities. Methods: Using spatial analysis techniques, we identified 3 communities with low vaccine uptake in Houston, Texas, in fall 2021; engaged 20 stakeholders from these communities via 4 focus groups to understand barriers to vaccination; and developed and implemented 3 COVID-19 vaccine education and outreach events tailored to the needs of these communities in January–March 2022. We used program evaluation surveys to assess attendee characteristics and satisfaction with the events. Vaccinated attendees also completed surveys on what motivated them to get vaccinated. Results: Two communities were predominantly Hispanic, and the third had an equal number of Black and Hispanic residents. Based on community stakeholder input, the study team organized 2 health fairs and 1 community festival featuring dialogue-based COVID-19 vaccine engagement in January and March 2022. Across the 3 events, a total of 865 attendees received COVID-19 education and 205 (24.0%) attendees received a COVID-19 vaccine or booster. Of 90 attendees who completed program evaluation surveys, 81 (90%) rated the outreach event as good or excellent. Of 145 attendees who completed postvaccination surveys, 132 (91%) endorsed ≥1 key program feature as motivating them to either get vaccinated or vaccinate their child that day. Conclusion: Community outreach events are important strategies for disseminating information, building trust, and facilitating COVID-19 vaccine uptake.
Longitudinal associations between psychedelic use and unusual visual experiences in the United States and the United Kingdom
Authors: Simonsson Otto , Hendricks Peter S , Stenfors Cecilia UD , Goldberg Simon B , Honk Ludwig , Osika Walter 
Published: December 2023

Background: Whereas findings from case reports and cross-sectional studies suggest that naturalistic psychedelic use may be associated with unusual visual experiences that occur after the acute pharmacological effects have subsided, such findings need to be replicated in longitudinal studies to better understand potential cause-and-effect relationships. Aims: To investigate longitudinal associations between naturalistic psychedelic use and unusual visual experiences. Methods: Using a longitudinal observational research design with samples representative of the US and UK adult populations with regard to sex, age, and ethnicity ( N = 9732), we investigated the relationship between psychedelic use during the 2-month study period and changes in past-week unusual visual experiences. Results: The follow-up survey was completed by 79% of respondents ( n = 7667), with 100 respondents reporting psychedelic use during the 2-month study period (1.3% of those who responded at follow-up). In covariate-adjusted regression models, the results showed that, as hypothesized, psychedelic use during the 2-month study period was associated with greater increases in unusual visual experiences. Notably, there was an interaction between lifetime psychedelic use and psychedelic use during the study period on unusual visual experiences such that those who used psychedelics for the first time reported greater increases in unusual visual experiences. Conclusions: Psychedelic use may elicit unusual visual experiences that occur after the acute pharmacological effects have subsided, especially among those who have not used psychedelics previously. Future longitudinal studies are warranted to further elucidate these relationships.
Analysis of Shared Mechanisms and Chinese Herbal Medicines Between Osteoporosis and Type 2 Diabetes
Authors: Yang Huawen , Luo Fanwei , Xiong Zhongyu 
Published: December 2023

Background Osteoporosis (OP) and type 2 diabetes (T2D) are commonly encountered metabolic disorders in clinical practice, but the comorbidity mechanism has not been clarified. This study explored the underlying mechanisms for utilizing bioinformatics methods. Furthermore, it predicted traditional Chinese medicines (TCMs) with preventive and therapeutic effects. Materials and Methods GSE35958 and GSE43950 were retrieved and downloaded from the GEO database, and differential expression analysis was performed to identify differentially expressed genes (DEGs) with similar expression patterns in OP and T2D. Then, the common DEGs were uploaded to the STRING database to construct a protein interaction network. Enrichment analysis of the screened genes was conducted using R language packages. Relevant TCMs were searched and screened based on gene targets using the Encyclopedia of traditional Chinese medicine (ETCM) database. Molecular docking of active ingredients of the TCMs and related gene targets was performed using AutoDock Vina software. Results By analyzing the gene expression microarrays, GSE35958 and GSE43950, 34 genes with the same expression pattern shared by OP and T2D were identified. Among these genes, 32 were upregulated and two were downregulated. Protein interaction network analysis revealed that tumor necrosis factor, vascular endothelial growth factor A, and CD44 might play key roles in the co-pathogenesis of T2D and OP. TCMs, including Wolfberry (枸杞), Ginseng (人参), and Yam (山药), were screened based on key genes. Molecular docking results demonstrated binding activity between all active ingredients and the related gene targets. Conclusion This study explored the potential molecular co-pathogenesis of OP and T2D through bioinformatic analysis and preliminarily predicted traditional herbal medicines that may have preventive and therapeutic effects.
Two-Year Survivorship and Patient-Reported Outcomes of a Prospectively Enrolled Cohort of INFINITY Total Ankle Arthroplasties
Authors: Doty Jesse , Murphy G. Andrew , Bohay Donald , Fortin Paul , Vora Anand , Strasser Nicholas , Friscia David , Newton William , Gross Christopher E. 
Published: December 2023

Background: The INFINITY total ankle implant is a widely and successfully used option for total ankle arthroplasty. The purpose of this study is to assess the 2-year survivorship, complication rates, patient-reported outcomes, and radiologic findings of prospectively enrolled patients undergoing a fixed-bearing total ankle arthroplasty (TAA). This study sought to determine if factors such as traditional vs patient-specific instrumentation, preoperative degree of arthritis, deformity, or etiology of arthritis impact surgical or clinical outcomes. Methods: A total of 143 prospectively enrolled patients (148 ankles) underwent TAA with a fixed-bearing total ankle implant between 2017 and 2019 at 9 different institutions by 9 different surgeons. A total of 116 completed 2-year follow-up. Patients were stratified by instrumentation used, degree of preoperative deformity, the Canadian Orthopaedic Foot and Ankle Society (COFAS) grading system, and etiology of arthritis. Outcomes used included implant survivorship and adverse events within 2 years of surgery. Additionally, patient-reported outcomes and radiographs were collected at 6-month, 1-year, and 2-year postoperatively. PROMs used included Ankle Osteoarthritis Score (AOS), Patient-Reported Outcomes Measurement Information System (PROMIS) global health score, the Foot and Ankle Outcome Score (FAOS), and patient satisfaction (rated from excellent to poor). Results: Implant survivorship at 2 years was 97.79%. There were 17 reoperations (11.5%), with 4 of the implants requiring revision (2.7%). Significant improvements in all PROMs were observed among all subgroups at all postoperative time points without significant variation between subgroups. Patients classified as COFAS type 2 arthritis preoperatively demonstrated significantly more improvement in FAOS Total Symptom Score at the 1- and 2-year measurements than COFAS type 3 patients at both time points. Conclusion: Total ankle arthroplasty with a fixed-bearing implant system is a safe and reliable treatment option for patients with end-stage arthritis regardless of degree of deformity or COFAS grading. Level of Evidence: Level II, prospective cohort study.
Introducing a core dataset for real-world data in multiple sclerosis registries and cohorts: Recommendations from a global task force
Authors: Parciak Tina , Geys Lotte , Helme Anne , van der Mei Ingrid , Hillert Jan , Schmidt Hollie , Salter Amber , Zakaria Magd , Middleton Rodden , Stahmann Alexander , Dobay Pamela , Hernandez Martinez-Lapiscina Elena , Iaffaldano Pietro , Plueschke Kelly , Rojas Juan I , Sabidó Meritxell , Magyari Melinda , van der Walt Anneke , Arickx Francis , Comi Giancarlo , Peeters Liesbet M 
Published: December 2023

Background: As of September 2022, there was no globally recommended set of core data elements for use in multiple sclerosis (MS) healthcare and research. As a result, data harmonisation across observational data sources and scientific collaboration is limited. Objectives: To define and agree upon a core dataset for real-world data (RWD) in MS from observational registries and cohorts. Methods: A three-phase process approach was conducted combining a landscaping exercise with dedicated discussions within a global multi-stakeholder task force consisting of 20 experts in the field of MS and its RWD to define the Core Dataset. Results: A core dataset for MS consisting of 44 variables in eight categories was translated into a data dictionary that has been published and disseminated for emerging and existing registries and cohorts to use. Categories include variables on demographics and comorbidities (patient-specific data), disease history, disease status, relapses, magnetic resonance imaging (MRI) and treatment data (disease-specific data). Conclusion: The MS Data Alliance Core Dataset guides emerging registries in their dataset definitions and speeds up and supports harmonisation across registries and initiatives. The straight-forward, time-efficient process using a dedicated global multi-stakeholder task force has proven to be effective to define a concise core dataset.