bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long Term Effects of a Social Capital-Based Exercise Adherence Intervention for Breast Cancer Survivors With Moderate Fatigue: A Randomized Controlled Trial
Authors: Han Jeehee , Jang Min Kyeong , Lee Hyojin , Kim Soo Yeon , Kim Sung Hae , Hee Ko Yun , Song Yoonkyung , Kang Min Jae , Jeon Justin Y. , Cho Young Up , Yi Gihong , Kim Sue 
Published: November 2023

Objectives: This study reports on the long-term effects of the Better Life After Cancer: Energy, Strength, and Support (BLESS) program, a 12-week social capital-based exercise adherence program for breast cancer survivors (BCS), implemented using a randomized controlled trial design. The study investigated outcomes related to cancer-related fatigue (CRF), quality of life (QOL), physical activity, depression, anxiety, sleep quality, and social capital. Methods: Participants who had moderate or greater CRF were randomly assigned to the intervention (n = 24), consisting of supervised and home-based exercise, or the control (n = 26), who received exercise leaflets. Generalized estimating equations models were fitted for the outcome variables. The assessment points were baseline (M1), immediately after completing the intervention at 12 weeks (M2), 1 month (M3), and 6 months post-intervention (M4). Results: A significant reduction in the total CRF score was found for both groups. We observed a significant time by group effect at M2, indicating a reduction of behavioral/severity CRF scores and a higher increase of physical activity. Also, there was an increase in the QOL score of both groups at M2, M3, and M4, compared to M1. Both groups had reduced anxiety at M3 and M4 compared to M1. The time by group effect for depression, sleep quality and social capital was not statistically significant. Conclusion: This 12-week exercise adherence program improved behavioral/severity CRF and physical activity post-intervention. Both the experimental group and control group showed significant improvements in CRF, QOL, and anxiety domains compared to the baseline, which extended to 6 months post-intervention. Trial registration: Korean Clinical Research Information Service (KCT0005763)
Reverse or Ulnar-Sided, Greater Arc Perilunate Injury: Case Report and Systematic Review of Literature
Authors: Zampeli Frantzeska , Marín Fermín Theodorakys , Hagert Elisabet , Arnaiz Javier , Andersson Jonny K. 
Published: November 2023

Background: Perilunate injuries of carpal bones are uncommon, high-energy injuries that necessitate early diagnosis and appropriate management to prevent progressive carpal instability and posttraumatic osteoarthritis. A much more uncommon mechanism that starts from the lunotriquetral ligament and proceeds radially in an opposite direction than the classic mechanism may cause a reverse or ulnar-sided perilunate dislocation (PLD). The purposes were: (1) to present an uncommon case of greater arc reverse (ulnar-sided) perilunate fracture-dislocation (REPLFD); and (2) to conduct a systematic review (SR) to evaluate the current evidence on reverse perilunate injuries (REPLIs). Methods: A novel pattern of injury of REPLFD with fractures of the ulnar styloid, triquetrum, and capitate is presented. A SR was conducted with primary outcome measures of the type of injury (pathoanatomy of lesions) and pathomechanics. Secondary outcome measures were choice of surgery and outcome on follow-up. Results: The Murad’s tool and modified Coleman Methodology Score revealed poor methodological quality of the available literature on REPLI. Evidence is lacking in the mechanism of injury and treatment of REPLI, especially regarding REPLFD. Conclusions: The SR revealed poor methodological quality of the available literature and exposes that not all PLDs can be explained by the current existing pathomechanical injury classifications. However, following the management principles of perilunate injuries, REPLI tends to have good functional results with no major complications. Level of Evidence: Level V.
Integration of a Safety Module to Prevent Rebound Hypoglycemia in Closed-Loop Artificial Pancreas Systems
Authors: Villa-Tamayo María F. , Colmegna Patricio , Breton Marc D. 
Published: November 2023

Background: With automated insulin delivery (AID) systems becoming widely adopted in the management of type 1 diabetes, we have seen an increase in occurrences of rebound hypoglycemia or generated hypoglycemia induced by the controller’s response to rapid glucose rises following rescue carbohydrates. Furthermore, as AID systems aim to enable complete automation of prandial control, algorithms are designed to react even more strongly to glycemic rises. This work introduces a rebound hypoglycemia prevention layer (HypoSafe) that can be easily integrated into any AID system. Methods: HypoSafe constrains the maximum permissible insulin delivery dose based on the minimum glucose reading from the previous hour and the current glucose level. To demonstrate its efficacy, we integrated HypoSafe into the latest University of Virginia (UVA) AID system and simulated two scenarios using the 100-adult cohort of the UVA/Padova T1D simulator: a nominal case including three unannounced meals, and another case where hypoglycemia was purposely induced by an overestimated manual bolus. Results: In both simulation scenarios, rebound hypoglycemia events were reduced with HypoSafe (nominal: from 39 to 0, hypo-induced: from 55 to 7) by attenuating the commanded basal (nominal: 0.27U vs. 0.04U, hypo-induced: 0.27U vs. 0.03U) and bolus (nominal: 1.02U vs. 0.05U, hypo-induced: 0.43U vs. 0.02U) within the 30-minute interval after treating a hypoglycemia event. No clinically significant changes resulted for time in the range of 70 to 180 mg/dL or above 180 mg/dL. Conclusion: HypoSafe was shown to be effective in reducing rebound hypoglycemia events without affecting achieved time in range when combined with an advanced AID system.
Polyphenol Content, Antioxidant, and Antibiotic Activities of Pinus Caribaea Morelet Forestry Coproducts
Authors: Sinyeue Cynthia , Maerker Louisa , Guentas Linda , Medevielle Valérie , Bregier Frédérique , Chaleix Vincent , Sol Vincent , Lebouvier Nicolas 
Published: November 2023

Context and objective In the context of valorization of wood waste from the timber industry, this work aims to study the chemical composition and to evaluate the biological capacities of coproducts from Pinus caribaea Morelet. Methods With this mind, sawdust, bark, and knot-wood from P caribaea were analyzed by high-performance liquid chromatography-mass spectrometry. The antioxidant activities of extracts and reference compounds were assessed in vitro using 2 methods: 2.2-diphenyl-1-picrylhydrazyl and 2.2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid). For antimicrobial evaluation, coproduct extracts were assayed against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Candida albicans. Results Despite the variable composition of sawdust, bark, and knot-wood, the composition of P caribaea is typical of the Pinus genus, with the presence of flavonoids, stilbenes, and lignans. Seven compounds were elucidated: 2 lignans (nortrachelogenin and matairesinol), 3 flavonoids (pinocembrin, pinobanksin, pinobanksin 3-acetate), 2 stilbenes (pinosylvin, pinosylvin monomethyl ether), and 1 phenolic acid (caffeic acid). Conclusion The ethanolic extracts of bark and knots showed significant antioxidant activity. The knots showed significant antibacterial properties against S epidermidis.
In-House Virtual Surgery Planning and 3D Printing for Head and Neck Surgery With Free Software: Our Workflow
Authors: Gómez Vicenç J. , Martín-González Antonio , Zafra-Vallejo Víctor , Zubillaga-Rodríguez Ignacio , Fernández-García Antonio , Sánchez-Aniceto Gregorio 
Published: November 2023

Study Design This study explores the workflow of in-house computer-aided design/manufacturing (CAD/CAM) in head and neck oncologic surgery, focusing on 3D printing of biomodels and cutting guides. Objective We aim to describe a validated workflow for an in-house 3D Printing Department within a level III University Hospital of the Spanish Public Health System using free software. Methods Our study outlines a cost-effective and time-efficient workflow utilizing free software for 3D printing. We assess the feasibility of establishing an in-house department compared to outsourcing to the biomedical industry. Results The study demonstrates that creating an in-house 3D Printing Department in a hospital setting is a viable option. We discuss the advantages, including cost savings and reduced lead times, as well as the limitations of this approach. Conclusions In conclusion, establishing an in-house 3D Printing Department has the potential to significantly streamline complex head and neck oncologic surgery procedures. This approach can enhance accessibility to advanced CAD/CAM, making them more efficient and cost-effective within the healthcare system.
Braimah-Taiwo et al New Classification System and Treatment Algorithm of Mandibulo-Maxillary Synostosis Related to Noma. Field Experience From Noma Children Hospital Sokoto, Nigeria
Authors: Braimah Ramat Oyebunmi , Taiwo A. O. , Olasoji H. O. , Legbo J. N. , Amundson M. , Ibikunle A. A. , Suleiman I. K. , Bala M. , Ile-Ogedengbe B. O. 
Published: November 2023

Study Design This was a retrospective study at Noma Children Hospital, Sokoto, Nigeria, from January 2018 to December 2021. Objective The main objective of this appraisal was to present Braimah-Taiwo et al’s new classification system for mandibulo-maxillary synostosis secondary to noma and also to provide a guide to their treatment. Methods Noma with mandibulo-maxillary synostosis was the main inclusion criteria. Excluded were cases of acute noma and noma without mandibulo-maxillary synostosis. Data retrieved include demographics of patients and extent of bony ankylosis and mandibulo-maxillary synostosis. Results A total of 64 patients (30 (46.9%) males and 34 (53.1%) females) were managed. Ages ranged from 6 to 40 years with mean ± SD (18.2 ± 7.6) years. Regarding the new classification system of mandibulo-maxillary synostosis, 6 (9.4%) patients presented with Type 1 (Mild joint obliteration)±Soft tissue scarring, 24 (37.5%) presented with Type II (Total joint obliteration)±Soft tissue scarring, 21 (32.8%) presented with Type III (Coronoid, zygoma and maxilla) ±Soft tissue scarring, 4 (6.3%) presented with Type IV (Condyle, glenoid fossa, coronoid, sigmoid notch and zygoma) ±Soft tissue scarring, 7 (10.9%) presented with Type V (Condyle, glenoid fossa, coronoid, sigmoid notch, zygoma and pterygo-maxilla) ±Soft tissue scarring, while 2 (3.1%) patients presented with Type VI (condyle, glenoid fossa, coronoid, sigmoid notch, zygoma, pterygo-maxilla and the orbit) ±Soft tissue scarring. Conclusions Pattern of tissue destruction in noma patients is complex involving both soft and hard tissues. This new classification will guide surgeons in the effective management of these patients.
The usability of two mobile health assistive technologies for wheelchair-related in-seat movement and pressure
Authors: Jordan Kathleen , Vos-Draper Tamara , Morrow Melissa , Sonenblum Sharon 
Published: November 2023

Introduction This study aimed to understand the degree to which two different mobile health assistive technologies, AW-Shift© and Sensoria® Mat, addressed seven constructs for managing wheelchair-related in-seat movement and pressure. Methods After using each intervention system, participants answered questions regarding the general usability and usefulness of the systems. Results System Usability Survey scores ranged from 5 (Poor) to 97.5 (Excellent), with a median response of 60.0 (Okay) for AW-Shift© and 76.3 (Good) for Sensoria® Mat. Participants reported using AW-Shift© to check areas of high pressure on their cushion, the quality of their weight shifts, and their posture significantly more often than to check the condition of their cushion or to track their movement goals. Participants reported using Sensoria® Mat to check the quality and number of weight shifts, and their posture significantly more often than to check the condition of their cushion. Conclusions The findings of this study highlight that there is no one-size-fits-all solution and that different subpopulations of wheelchair users may have different needs and preferences. Optimizing the design for specific cohorts or constructs can result in an effective product that consistently provides meaningful and accurate information about behavior and performance.
Complications Have Not Improved With Newer Generation Robots
Authors: Farivar Daniel , Kim Terrence T. , Sy Christopher A. , Baron Eli M. , Nomoto Edward K. , Walker Corey T. , Skaggs David L. 
Published: November 2023

Study Design Retrospective cohort study. Objective The purpose of this study was to see whether upgrades in newer generation robots improve safety and clinical outcomes following spine surgery. Methods All patients undergoing robotic-assisted spine surgery with the Mazor X Stealth EditionTM (Medtronic, Minneapolis, MN) from 2019 to 2022 at a combined orthopedic and neurosurgical spine service were retrospectively reviewed. Robot related complications were recorded. Results 264 consecutive patients (54.1% female; age at time of surgery 63.5 ± 15.3 years) operated on by 14 surgeons were analyzed. The average number of instrumented levels with robotics was 4.2 ± 2.7, while the average number of instrumented screws with robotics was 8.3 ± 5.3. There was a nearly 50/50 split between an open and minimally invasive approach. Six patients (2.2%) had robot related complications. Three patients had temporary nerve root injuries from misplaced screws that required reoperation, one patient had a permanent motor deficit from the tap damaging the L1 and L2 nerve roots, one patient had a durotomy from a misplaced screw that required laminectomy and intra-operative repair, and one patient had a temporary sensory L5 nerve root injury from a drill. Half of these complications (3/6) were due to a reference frame error. In total, four patients (1.5%) required reoperation to fix 10 misplaced screws. Conclusion Despite newer generation robots, robot related complications are not decreasing. As half the robot related complications result from reference frame errors, this is an opportunity for improvement.
Microvascular Soft Tissue Reconstruction Outcomes and Risk Factors in Pediatric Patients Undergoing Head and Neck Reconstruction
Authors: James Justin , Seyidova Nargiz , Takyi Evans , Oleru Olachi , Taub Peter J. 
Published: November 2023

Background: Despite improvements in microsurgical techniques and broad application of free tissue transfer for reconstruction in the adult population, there is currently a paucity of literature regarding microsurgical reconstruction in the pediatric population, notably a limited number of case series evaluating outcomes following head and neck reconstruction. Methods: A retrospective analysis of National Surgical Quality Improvement Program Pediatric (NSQIP-P) database from 2015 to 2020 was performed. Pediatric patients undergoing head and neck reconstruction with microvascular muscle and fasciocutaneous flaps were identified using Current Procedural terminology codes (CPT). Multivariate logistic regressions were conducted to assess postoperative outcomes of interest. Results: A total of 120 head and neck free flap reconstructions were performed in the pediatric population. Most free flaps were microvascular muscle (n = 82, 68%) followed by fasciocutaneous (n = 38, 32%) flaps. The surgical complication rate was 8% (n = 9) and was primarily due to wound infection 6% (n = 7), whereas medical related complication rate was 14% (n = 17) with majority of patients requiring blood transfusion 12% (n = 14). The median length of stay was 4 days, and ventilator dependence was found to be significantly different among microvascular free flap types. Patients with underweight BMI and ASA Class >2 had higher odds (OR 59.7 and 17.0, P < .05 respectively) of developing any complication for microvascular muscle flaps. Conclusion: Analysis of a national cohort of pediatric patients revealed a low flap-related complication rate. Although free flap reconstruction in the pediatric population is technically demanding, microsurgical free tissue transfer in this population is safe and should be considered if indicated.
Exploring the Relationship Between Sonographers’ Work-Related Musculoskeletal Disorders and Occupational Burnout
Authors: Bagley Jennifer E. , Amos Danielle , Baldwin Jonathan D. 
Published: November 2023

Objective: Work-related musculoskeletal disorders (WRMSDs) are injuries developed through repetitive use or strain. These may lead to an early career-ending injury. Work-related burnout has also been documented among sonographers, but the potential relationship between WRMSDs and burnout has not been well studied. Material and Methods: A 43-question survey was sent to sonographers and included questions regarding work culture, presence of WRMSDs, early career-ending injury, and occupational burnout. The Oldenburg Burnout Inventory was used to determine gauge occupational burnout. Results: Of 127 respondents, 64% (n = 81) reported a WRMSD and 76% (n = 96) self-reported occupational burnout. The total burnout score was 3.3 points higher among those reporting a WRMSD, compared with those not reporting. ( P = .0077). Conclusion: Work-related musculoskeletal disorders and occupational burnout were associated conditions among this group of sonographers. Hospital and clinic administrators should listen to employees to identify potential occupational burnout or a WRMSD, prior to either condition resulting in an exit from the profession.
Nonactivated and IL-7 cultured CD19-specific CAR T cells are enriched in stem cell phenotypes and functionally superior
Authors: Wang Siao-Yi , Scurti Gina M. , Dalheim Annika V. , Quinn Suzanne , Stiff Patrick J. , Nishimura Michael I. 
Published: November 2023

Abstract
CD19-specific chimeric antigen receptor (CAR) T cells have demonstrated impressive responses in patients with relapsed and refractory B cell malignancies. However, many patients relapse or fail to respond to CD19 CAR T cells, demonstrating the need to improve its efficacy and durability. Current protocols for generating CAR T cells involve T cell activation through CD3 stimulation to facilitate efficient CAR transfer followed by ex vivo expansion with exogenous cytokines to obtain adequate cell numbers for treatment. Both T cell activation and expansion inevitably lead to terminal differentiation and replicative senescence, which are suboptimal for therapy. Interleukin-7 (IL-7) was previously shown to allow for lentiviral transduction of T cells in the absence of activation. In these studies, we used IL-7 to generate CD19 CAR T cells without stimulating CD3. Nonactivated and IL-7 cultured (NICE) CD19 CAR T cells were enriched with the T memory stem cell population, retained novel markers of stemness, had lower expression of exhaustion markers, and increased proliferative potential. Furthermore, our findings are consistent with engraftment of NICE CD19 CAR T cells and demonstrate a superior therapeutic response in both intraperitoneal and subcutaneous in vivo B cell lymphoma models. These results suggest that NICE CD19 CAR T cells may improve outcomes for B cell malignancies and warrant clinical evaluation.
Safety of bendamustine for the treatment of indolent non-Hodgkin lymphoma: a UK real-world experience
Authors: Shotton Rohan , Broadbent Rachel , Alchawaf Alia , Mohamed Mohamed Bakri , Gibb Adam , Martinez-Calle Nicolás , Fox Christopher P. , Bishton Mark , Pender Alexandra , Gleeson Mary , Cunningham David , Davies Andrew , Yadollahi Sina , Eyre Toby A. , Collins Graham , Djebbari Faouzi , Kassam Shireen , Garland Paula , Watts Emily , Osborne Wendy , Townsend William , Pocock Rachael , Ahearne Matthew J. , Miall Fiona , Wang Xin , Linton Kim M. 
Published: November 2023

Abstract
Bendamustine is among the most effective chemotherapeutics for indolent B-cell non-Hodgkin lymphomas (iNHL), but trial reports of significant toxicity, including opportunistic infections and excess deaths, led to prescriber warnings. We conducted a multicenter observational study evaluating bendamustine toxicity in real-world practice. Patients receiving at least 1 dose of bendamustine with/without rituximab (R) for iNHL were included. Demographics, lymphoma and treatment details, and grade 3 to 5 adverse events (AEs) were analyzed and correlated. In total, 323 patients were enrolled from 9 National Health Service hospitals. Most patients (96%) received bendamustine-R, and 46%, R maintenance. Overall, 21.7% experienced serious AEs (SAE) related to treatment, including infections in 12%, with absolute risk highest during induction (63%), maintenance (20%), and follow-up (17%) and the relative risk highest during maintenance (54%), induction (34%), and follow-up (28%). Toxicity led to permanent treatment discontinuation for 13% of patients, and 2.8% died of bendamustine-related infections (n = 5), myelodysplastic syndrome (n = 3), and cardiac disease (n = 1). More SAEs per patient were reported in patients with mantle cell lymphoma, poor preinduction performance status (PS), poor premaintenance PS, and abnormal preinduction total globulins and in those receiving growth factors. Use of antimicrobial prophylaxis was variable, and 3 of 10 opportunistic infections occurred despite prophylaxis. In this real-world analysis, bendamustine-related deaths and treatment discontinuation were similar to those of trial populations of younger, fitter patients. Poor PS, mantle cell histology, and maintenance R were potential risk factors. Infections, including late onset events, were the most common treatment-related SAE and cause of death, warranting extended antimicrobial prophylaxis and infectious surveillance, especially for maintenance-treated patients.
Structural analysis of platelet fragments and extracellular vesicles produced by apheresis platelets during storage
Authors: De Paoli Silvia H. , Patel Mehulkumar , Elhelu Oumsalama K. , Tarandovskiy Ivan D. , Tegegn Tseday Z. , Simak Jan 
Published: November 2023

Abstract
Platelets (PLTs) for transfusion can be stored for up to 7 days at room temperature (RT). The quality of apheresis PLTs decreases over storage time, which affects PLT hemostatic functions. Here, we characterized the membranous particles produced by PLT storage lesion (PSLPs), including degranulated PLTs, PLT ghosts, membrane fragments, and extracellular membrane vesicles (PEVs). The PSLPs generated in apheresis platelet units were analyzed on days 1, 3, 5, and 7 of RT storage. A differential centrifugation and a sucrose density gradient were used to separate PSLP populations. PSLPs were characterized using scanning and transmission electron microscopy (EM), flow cytometry (FC), and nanoparticle tracking analysis (NTA). PSLPs have different morphologies and a broad size distribution; FC and NTA showed that the concentration of small and large PSLPs increases with storage time. The density gradient separated 3 PSLP populations: (1) degranulated PLTs, PLT ghosts, and large PLT fragments; (2) PEVs originated from PLT activation and organelles released by necrotic PLTs; and (3) PEV ghosts. Most PSLPs expressed phosphatidyl serine and induced thrombin generation in the plasma. PSLPs contained extracellular mitochondria and some had the autophagosome marker LC3. PSLPs encompass degranulated PLTs, PLT ghosts, large PLT fragments, large and dense PEVs, and low-density PEV ghosts. The activation-related PSLPs are released, particularly during early stage of storage (days 1-3), and the release of apoptosis- and necrosis-related PSLPs prevails after that. No elevation of LC3- and TOM20-positive PSLPs indicates that the increase of extracellular mitochondria during later-stage storage is not associated with PLT mitophagy.