bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of nonpharmacological multi‐component intervention on depressive symptoms in patients with mild cognitive impairment and dementia: A systematic review and meta‐analysis
Authors: Cai Mingjin , Bai Dingxi , Hou Dongjiang , You Qian , Wang Wei , Lu Xianying , Gao Jing 
Published: November 2023

AbstractPatients with mild cognitive impairment (MCI) and dementia are more prone to depression than people without MCI or dementia. Some studies have found nonpharmacological multi‐component intervention to be more effective than single‐component intervention in improving the condition of patients with MCI and dementia; however, their effect on depressive symptoms is still inconsistent. Therefore, it is necessary to explore the effectiveness of nonpharmacological multi‐component intervention in improving depressive symptoms in patients with MCI and dementia. This review retrieved papers from PubMed, Embase, Cochrane Library, CINAHL, PsycINFO and CNKI. The retrieval time limit was set from 1 January 1990 to 25 November 2022. The PRISMA 2020 guideline was used to report the included studies. The result showed that nonpharmacological multi‐component intervention could improve depressive symptoms in patients with MCI and dementia. Among them, nonpharmacological multi‐component intervention with a duration of <6 months, physical and cognitive activities, or other activities had significant effects. However, each study differed in terms of specific measures, duration and frequency of intervention methods. Accordingly, more randomized controlled trials with larger samples are required to discover the best scheme for nonpharmacological multi‐component intervention.
Effect of transverse colostomy versus ileostomy in colorectal anastomosis on post‐operative wound complications: A meta‐analysis
Authors: Zhang Qixin , Liu Fei , Li Yao , Ji Lin , Yu Yanchun , Yang Xingju 
Published: November 2023

AbstractA meta‐analysis was conducted to evaluate the effect of colostomy or ileostomy on post‐operative wound complications. The research was tested using Embase, PubMed and Cochrane Library databases. Included were randomized, controlled clinical trials (RCTs). A sensitivity analysis and a meta‐analysis were carried out. The results indicated that there were no statistically significant differences in the reduction of wound infection between LC and LI. Out of 268 related studies, 5 publications were chosen and examined for compliance. Literature quality was evaluated throughout the trial. Studies with poor literature were excluded. The data were analysed with RevMan 5.3, and a decision was taken to analyse the data with either a stochastic or a fixed‐effects model. There were no significant differences in the incidence of post‐operative infection in patients with LC (OR, 0.79; 95% CI, 0.34, 1.81; p = 0.57), and the incidence of post‐operative anastomotic fistulae (OR, 0.98; 95% CI, 0.30, 3.15; p = 0.97) was not significantly different from that with LI. These meta‐analyses indicate that no significant reduction in the incidence of post‐operative infections or anastomotic fistulae was observed by either LC or LI.
Care call requests and inpatient beds modernization: Is there any link? A prospective observational study in the oncological setting
Authors: Panattoni Nicolò , Sperduti Isabella , Spano Alessandro , De Leo Aurora , Petrone Fabrizio , Di Simone Emanuele 
Published: November 2023

AbstractAimThe study aims to analyse the principal causes of patients' care calls and compare differences before and after inpatient beds' technological modernization in a surgical breast oncological ward.DesignA prospective observational study was conducted under the STROBE guidelines. Data were collected from June to September 2022.MethodsStatistical analyses were performed to compare each reason for care calls, by shifts and pre and post‐inpatient bed modernization.ResultsTwo thousand five hundred and fifty‐nine care request calls were analysed during the 202 observed shifts. The most frequent reason was related to the requests for positions.ConclusionTechnological modernization of the beds has not led to effective—positive—changes; on the contrary, it seems at first glance to show an upward trend in calls above all in the short period after the changes.Implications for the profession and/or patient care

What problem did the study address? By analysing the principal causes of care calls and comparing the differences before and after inpatient beds' technological modernization, this study evaluates if inpatient gear or device modernization can impact care call requests.

What were the main findings? The results show that the most frequent reasons for care calls were position, possession and other. These findings seem not superimposable; the hypothesis supported by the international literature in which the causes relating to potty and pain were found among the main reasons.

Where and on whom will the research have an impact? These results could impact the care organizational area in nursing care and could improve care quality, patient satisfaction and safety.

Reporting MethodThis prospective observational study was conducted following STROBE guidelines.Patient or Public ContributionAfter adequate information (presentation, design methods and objectives), all unit healthcare staff agreed to collaborate in the study.
Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population
Authors: Kocevska Desana , Trajanoska Katerina , Mulder Rosa H. , Koopman‐Verhoeff M. Elisabeth , Luik Annemarie I. , Tiemeier Henning , van Someren Eus J.W. 
Published: November 2023

BackgroundTwin studies show moderate heritability of sleep traits: 40% for insomnia symptoms and 46% for sleep duration. Genome‐wide association studies (GWAS) have identified genetic variants involved in insomnia and sleep duration in adults, but it is unknown whether these variants affect sleep during early development. We assessed whether polygenic risk scores for insomnia (PRS‐I) and sleep duration (PRS‐SD) affect sleep throughout early childhood to adolescence.MethodsWe included 2,458 children of European ancestry (51% girls). Insomnia‐related items of the Child Behavior Checklist were reported by mothers at child's age 1.5, 3, and 6 years. At 10–15 years, the Sleep Disturbance Scale for Children and actigraphy were assessed in a subsample (N = 975). Standardized PRS‐I and PRS‐SD (higher scores indicate genetic susceptibility for insomnia and longer sleep duration, respectively) were computed at multiple p‐value thresholds based on largest GWAS to date.ResultsChildren with higher PRS‐I had more insomnia‐related sleep problems between 1.5 and 15 years (BPRS‐I < 0.001 = .09, 95% CI: 0.05; 0.14). PRS‐SD was not associated with mother‐reported sleep problems. A higher PRS‐SD was in turn associated with longer actigraphically estimated sleep duration (BPRS‐SD < 5e08 = .05, 95% CI: 0.001; 0.09) and more wake after sleep onset (BPRS‐SD < 0.005 = .25, 95% CI: 0.04; 0.47) at 10–15 years, but these associations did not survive multiple testing correction.ConclusionsChildren who are genetically predisposed to insomnia have more insomnia‐like sleep problems, whereas those who are genetically predisposed to longer sleep have longer sleep duration, but are also more awake during the night in adolescence. This indicates that polygenic risk for sleep traits, based on GWAS in adults, affects sleep already in children.
Secured credit and bankruptcy resolution
Authors: Adler Barry E. , Capkun Vedran 
Published: November 2023

AbstractAccepted wisdom holds that secured creditors favor liquidation of a debtor in bankruptcy even where the debtor may be more valuable as a going concern. This is false wisdom, however. Holders of senior claims can be expected to favor liquidation prior to a debtor's bankruptcy because the return on such claims are capped by the amount owed while debtor asset values fluctuate. But bankruptcy is a day of reckoning that can eliminate a creditor's exposure to value fluctuation. For this reason, we expect that modern bankruptcy practice, with the secured creditor often firmly in control, does not unduly encourage liquidation. In fact, we expect any bias to favor reorganization, which can be manipulated for the benefit of any party in control of the bankruptcy process. Our results are consistent with this hypothesis. In a broad study of US corporate bankruptcy cases, we find that secured credit is positively and significantly correlated with the reorganization of insolvent debtors.
Effects of the GingivalStat approach on early gingival margin remodeling following esthetic clinical crown lengthening: A case series
Authors: Garcia‐Valenzuela Francisco Salvador , Chambrone Leandro 
Published: November 2023

AbstractObjectivesThe aim of this case series is to present the potential applications of the GingivalStat approach, that is, the use of temporary gingival stabilizers, to favor early gingival margin remodeling and prevent the occurrence of gingival rebound following esthetic clinical crown lengthening.Clinical ConsiderationsFour patients requiring clinical crown lengthening were treated for esthetical and functional reasons. The surgical approach included: (a) gingival margin recontouring; (b) full‐thickness flap elevation; (c) osteotomy (to achieve an adequate dimension between the alveolar bone crest and the CEJ) and osteoplasty (to reduce the bone thickness and improve the buccal bone anatomic profile, where indicated); (d) temporary gingival stabilizer placement using a block‐out resin or a composite (the GingivalStat approach); and (e) flap repositioning, adaptation, and suture. One‐ to five‐year follow‐ups, reported in the different case scenarios, show evidence of clinically stable gingival margins around the treated teeth.ConclusionsWithin the limits of this case series, it can be concluded that the GingivalStat approach appears as a further maneuver to cope with clinical crown lengthening procedures at esthetic sites. GingivalStat seems to favor gingival margin contour remodeling during the early phase of healing as well as prevent the occurrence of gingival rebound.Clinical SignificanceGingivalStat approach may guide gingival margin remodeling and prevent gingival rebound after wound healing of sites submitted to esthetic clinical crown lengthening.
Caregiving and all‐cause mortality in postmenopausal women: Findings from the Women's Health Initiative
Authors: Chavan Prachi P. , Weitlauf Julie C. , LaMonte Michael J. , Sisto Sue Ann , Tomita Machiko , Gallagher‐Thompson Dolores , Shadyab Aladdin H. , Bidwell Julie T. , Manson JoAnn E. , Kroenke Candyce H. , Hayden Kathleen M. , Hirsch Calvin H. , Mouton Charles P. , Cannell Michael B. , Hovey Kathleen M. , Wactawski‐Wende Jean 
Published: November 2023

AbstractBackgroundCaregiving is commonly undertaken by older women. Research is mixed, however, about the impact of prolonged caregiving on their health, well‐being, and mortality risk. Using a prospective study design, we examined the association of caregiving with mortality in a cohort of older women.MethodsParticipants were 158,987 postmenopausal women aged 50–79 years at enrollment into the Women's Health Initiative (WHI) who provided information on current caregiving status and caregiving frequency at baseline (1993–1998) and follow‐up (2004–2005). Mortality was ascertained from baseline through March of 2019. Cox regression with caregiving status defined as a time‐varying exposure was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for mortality, adjusting for sociodemographic factors, smoking, and history of diabetes, hypertension, cardiovascular disease (CVD), and cancer. Stratified analyses explored whether age, race‐ethnicity, depressive symptoms, frequency of caregiving, optimism, and living status modified the association between caregiver status and mortality.ResultsAt baseline, 40.7% of women (mean age 63.3 years) self‐identified as caregivers. During a mean 17.5‐year follow‐up, all‐cause mortality (50,526 deaths) was 9% lower (multivariable‐adjusted HR = 0.91, 95% CI: 0.89–0.93) in caregivers compared to non‐caregivers. The inverse association between caregiving and all‐cause mortality did not differ according to caregiving frequency or when stratified by age, race‐ethnicity, depressive symptoms, optimism, or living status (interaction p > 0.05, all). Caregiving was inversely associated with CVD and cancer mortality.ConclusionAmong postmenopausal women residing across the United States, caregiving was associated with lower mortality. Studies detailing the type and amount of caregiving are needed to further determine its impact on older women.
Primed conversion: The emerging player of precise and nontoxic photoconversion
Authors: Kalyviotis Konstantinos , Pantazis Periklis 
Published: November 2023

AbstractIn 2015, we reported primed conversion, a novel way to convert green‐to‐red photoconvertible fluorescent proteins, which emerges as a powerful tool for precision optical imaging. Primed conversion uses the intercept of blue and red‐to‐far‐red light instead of traditional violet or near‐UV light illumination which offers a series of advantages. Here, we review the fundamental principles and applications of primed conversion with a focus on its use in single‐cell labelling and lineage tracing. We provide a historical perspective of lineage tracing techniques, thereby covering basic principles of fluorescence, photoconvertible fluorescent proteins, and eventually primed conversion. We then present the molecular requirements for primed conversion to take place and showcase how it can be used for dual‐colour high‐fidelity lineage tracing. Further, we discuss potential future developments of the primed conversion imaging toolkit that can benefit the study of both development and disease progression.
Best practices for communication while wearing facemasks: A scoping review
Authors: Shaw Clarissa A. , Lee Kyu Ri , Williams Alexander , Shaw Nathan A. , Weeks Delaney , Jackson Lainie , Williams Kristine N. 
Published: November 2023

AbstractIntroductionFacemasks are an important piece of personal protective equipment (PPE) to mitigate the spread of respiratory illnesses, but they can impede communication between patients and healthcare providers. The purpose of this scoping review is to identify effective communication practices while wearing facemasks.DesignScoping review using a systematic search of articles from the PubMed, CINAHL, and Embase databases.MethodsThe PEO (population, exposure, outcome) methodology was selected for this systematic scoping review. The population of interest (P) includes humans of all ages (children, adults, and older adults); the exposure of interest (E) is PPE that covers the mouth (i.e., facemasks); and the outcome of interest (O) is successful or unsuccessful communication practices. The Johns Hopkins Evidence‐Based Practice for Nurses and Healthcare Professionals appraisal guidelines were used to determine the level and quality of the research.ResultsThirty‐nine articles met the inclusion criteria. Seventeen of these were high‐ or good‐quality research studies, and the remaining 22 were non‐research articles included with separate analysis as part of the scoping review. The 17 articles encompassed 2656 participants. The highest quality evidence indicated that standard surgical masks have the least impact on speech perception compared to other non‐transparent mask types, and that recognizing emotions is less accurate with facemasks, necessitating compensatory actions (i.e., reducing extraneous noise, using a microphone to amplify voice, and employing clear speech). Evidence was contradictory regarding the use of transparent masks. Evidence was of limited quality for other non‐verbal and verbal communication strategies.ConclusionAwareness of communication challenges is crucial when wearing facemasks. More high‐quality studies are needed to evaluate communication techniques when speakers are wearing facemasks. Basic strategies such as selecting an appropriate mask type, reducing extraneous noise, using microphones, verbalizing emotions, and employing clear speech appear to be beneficial.Clinical RelevanceThe findings of this scoping review highlight the importance of considering communication challenges while wearing facemasks in the healthcare settings. The review suggests that selecting an appropriate mask type, reducing extraneous noise, verbalizing emotions, and employing clear speech are some strategies that may be effective in mitigating the impact of facemasks on communication between patients and healthcare providers.
What do brain endocasts tell us? A comparative analysis of the accuracy of sulcal identification by experts and perspectives in palaeoanthropology
Authors: Labra Nicole , Mounier Aurélien , Leprince Yann , Rivière Denis , Didier Mélanie , Bardinet Eric , Santin Mathieu D. , Mangin Jean François , Filippo Andréa , Albessard‐Ball Lou , Beaudet Amélie , Broadfield Douglas , Bruner Emiliano , Carlson Kristian J. , Cofran Zachary , Falk Dean , Gilissen Emmanuel , Gómez‐Robles Aida , Neubauer Simon , Pearson Alannah , Röding Carolin , Zhang Yameng , Balzeau Antoine 
Published: November 2023

AbstractPalaeoneurology is a complex field as the object of study, the brain, does not fossilize. Studies rely therefore on the (brain) endocranial cast (often named endocast), the only available and reliable proxy for brain shape, size and details of surface. However, researchers debate whether or not specific marks found on endocasts correspond reliably to particular sulci and/or gyri of the brain that were imprinted in the braincase. The aim of this study is to measure the accuracy of sulcal identification through an experiment that reproduces the conditions that palaeoneurologists face when working with hominin endocasts. We asked 14 experts to manually identify well‐known foldings in a proxy endocast that was obtained from an MRI of an actual in vivo Homo sapiens head. We observe clear differences in the results when comparing the non‐corrected labels (the original labels proposed by each expert) with the corrected labels. This result illustrates that trying to reconstruct a sulcus following the very general known shape/position in the literature or from a mean specimen may induce a bias when looking at an endocast and trying to follow the marks observed there. We also observe that the identification of sulci appears to be better in the lower part of the endocast compared to the upper part. The results concerning specific anatomical traits have implications for highly debated topics in palaeoanthropology. Endocranial description of fossil specimens should in the future consider the variation in position and shape of sulci in addition to using models of mean brain shape. Moreover, it is clear from this study that researchers can perceive sulcal imprints with reasonably high accuracy, but their correct identification and labelling remains a challenge, particularly when dealing with extinct species for which we lack direct knowledge of the brain.
Accuracy of Crit‐Line® monitors in predicting hematocrit and change in blood volume of dogs during hemodialysis
Authors: Vickery Whitney E. , Steinbach Sarah M. L. , Moore George E. 
Published: November 2023

AbstractBackgroundUltrafiltration (UF) is an extracorporeal technique for treating fluid overload and is monitored with noninvasive blood volume monitors.Hypothesis/ObjectivesThe primary objective was to determine the accuracy of Crit‐Line® III and IV noninvasive blood volume monitors to estimate canine packed cell volume (PCV) and changes in blood volume during UF. A secondary aim was to determine accuracy of targeted ultrafiltration rates (UFR) compared to calculated delivered UFR.MethodsAn ex vivo study with a single Phoenix® X36 platform and canine packed red blood cells (pRBC) was performed. Through dilution and UF, clinically applicable PCV values were obtained and compared to Crit‐Line® hematocrit (Hct). Blood volume was constantly measured and compared to targeted UFR. Systematic and proportional bias were calculated using a Bayes method.ResultsCrit‐Line® III and IV reported Hct was significantly lower than PCV (n = 140, median 26%, range, 8%‐50%) when PCV was >25% and >30%, respectively. Crit‐Line® III and IV calculated change in blood volume (ΔBV%) was significantly different from measured blood volume changes at ΔBV% ±20% and >−20%, respectively. Comparing targeted and delivered UFR (mL/h), less than targeted UFR was removed at UFR100 through UFR400 and UFR0 adding volume.Conclusions and Clinical ImportanceCrit‐Line® III and IV monitors provide accurate estimates of canine PCV and UF volume change within specific ranges and are useful in monitoring canine UF and hemodialysis. Veterinary hemodialysis services should evaluate individual machines for UFR inaccuracies, which can meaningfully affect small animals.
Utilizing ISSRseq genotyping to assist growth selection in tomato grouper (Cephalopholis sonnerati) without broodstock information
Authors: Hsu Te‐Hua , Chu Pei‐Yun , Gong Hong‐Yi , Nan Fan‐Hua , Huang Chang‐Wen 
Published: November 2023

AbstractGrowth selection in fish is essential for aquaculture; however, long generation times and artificial breeding limitations present challenges for breeding endeavors. The tomato grouper (Cephalopholis sonnerati) is an emerging aquaculture species with a generation cycle of at least 5 to 10 years. Mixed culture of broodstocks and natural mating are commonly employed in hatcheries. To expedite the selection process for tomato grouper, we utilized ISSRseq technology for assisted future growth selection. After 6 months of rearing, we selected 48 individuals, including 24 fast‐growing and 24 slow‐growing individuals (representing the top and bottom 10% of samples). These samples produced 932 SNPs. Although specific broodstock pairing information is unavailable, our results suggest that these fry likely originated from multiple broodstock exhibiting considerable diversity. Further analysis of genetic relationships among individuals revealed three main clades. One clade contained a higher proportion of faster‐growing individuals (80%), while another featured a lower proportion of rapidly growing individuals (28.6%). Through the relatedness network and further exclusion of individuals, the faster‐growth clade comprised 92.3% of fast‐growing individuals. The faster‐growth clade is appropriate for further development into a high‐growth strain. Our findings demonstrate that molecular markers can advance population selective breeding to family selection in aquaculture breeding research.
Humoral immunity to phlebovirus infection
Authors: Doores Katie J. 
Published: November 2023

AbstractPhleboviruses are zoonotic pathogens found in parts of Africa, Asia, Europe, and North America and cause disease symptoms ranging from self‐limiting febrile illness to severe disease, including hemorrhagic diathesis, encephalitis, and ocular pathologies. There are currently no approved preventative vaccines against phlebovirus infection or antivirals for the treatment of the disease. Here, we discuss the roles of neutralizing antibodies in phlebovirus infection, the antigenic targets present on the mature polyproteins Gn and Gc, progress in vaccine development, and the prospects of identifying conserved neutralizing epitopes across multiple phleboviruses. Further research in this area will pave the way for the rational design of pan‐phlebovirus vaccines that will protect against both known phleboviruses but also newly emerging phleboviruses that may have pandemic potential.