bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR‐423 Coding Region Genetic Polymorphism rs8067576 May Associate With the Risk of Developing Recurrent Spontaneous Abortion: A Case‐Control Study in a Chinese Han Population
Authors: Su Xing , Yu Wan‐Ying , Zhao Ming‐Jia , Hu Yi , Li Ying , Wang Xue‐Qin , Zhang Lu , Lv Xiao‐Dan , Ma Xu , Xia Hong‐Fei 
Published: January 2025

ABSTRACTBackgroundOur previous study has identified an association of a single nucleotide polymorphism (SNP) in the miR‐423 gene with recurrent spontaneous abortion (RSA). The presence of additional RSA‐linked SNPs in the miR‐423 gene remains unclear.MethodsWe evaluated polymorphisms in the coding region of miR‐423 in Han Chinese women with unexplained RSA (URSA).ResultsSignificant differences were observed in the genotype and allele distribution of miR‐423 rs8067576 between patients with RSA and control subjects. A robust association was found between an elevated RSA incidence and the presence of A/T heterozygosity in miR‐423 rs8067576, with an odds ratio (OR) of 1.76 (95% confidence interval [CI]: 1.26 to 2.47, p = 0.000292). The rare allele T in the pre‐miR‐423 sequence was shown to cause a discernible structural change and a reduced ΔG value. Compared with the A allele, the rare T allele promoted cell proliferation. Furthermore, compared with the T allele, the A allele in the rs8067576 polymorphism exhibited a greater ability to inhibit the translation of proliferation‐associated 2 group 4 (Pa2g4), which is the functional target of miR‐423. The T allele in the rs8067576 polymorphism was also found to be more susceptible to the inhibition of cell proliferation induced by mifepristone.ConclusionsThe rs8067576 A > T polymorphism in the miR‐423 gene may serve as a genetic susceptibility locus for RSA. This polymorphism appears to contribute to an increased risk of acquiring URSA in humans by destroying mature miR‐423.
MHC Class II‐Expressing Mucosal Mast Cells Promote Intestinal Mast Cell Hyperplasia in a Mouse Model of Food Allergy
Authors: Oishi Kenji , Nakano Nobuhiro , Ota Masamu , Inage Eisuke , Izawa Kumi , Kaitani Ayako , Ando Tomoaki , Hara Mutsuko , Ohtsuka Yoshikazu , Nishiyama Chiharu , Ogawa Hideoki , Kitaura Jiro , Okumura Ko , Shimizu Toshiaki 
Published: January 2025

ABSTRACTBackgroundIgE‐mediated food allergy is accompanied by mucosal mast cell (MMC) hyperplasia in the intestinal mucosa. Intestinal MMC numbers correlate with the severity of food allergy symptoms. However, the mechanisms by which MMCs proliferate excessively are poorly understood. Here, we clarify the role of newly identified MHC class II (MHCII)‐expressing MMCs in the effector phase of IgE‐mediated food allergy.MethodsMice reconstituted with MHCII‐deficient or wild‐type MMCs were used to generate a mouse mode of IgE‐mediated food allergy. We assessed the extent of intestinal MMC hyperplasia and the severity of hypothermia in these mice. In addition, we performed in vitro antigen presentation assay using induced MHCII‐expressing MMCs generated from bone marrow cells to evaluate the effect of CD4+ T cell activation on MMC proliferation.ResultsIn food‐allergic mice, we identified the appearance of MHCII‐expressing MMCs in the intestinal mucosa and showed that MMC hyperplasia was suppressed in mice with MHCII‐deficient MMCs compared to mice with wild‐type MMCs. In vitro assays demonstrated that MHCII‐expressing MMCs incorporate food antigens directly and through the high‐affinity IgE receptor FcεRI‐mediated endocytosis and activate antigen‐specific CD4+ T cells from food‐allergic mice by antigen presentation. Activated CD4+ T cells secrete IL‐4 and large amounts of IL‐5, which enhance production of the mast cell growth factor IL‐9 by IL‐33‐activated MMCs. Excess IL‐9 causes excessive MMC proliferation, leading to the development of MMC hyperplasia.ConclusionAntigen presentation to CD4+ T cells by MHCII‐expressing MMCs triggers intestinal MMC hyperplasia and exacerbates IgE‐mediated food allergy.
Why do most people on dialysis not accept psychological care to increase perceptions of control in life?
Authors: de Vries Alicia M. , Ranchor Adelita V. , Westerhuis Ralf , Visser Annemieke , Franssen Casper F. M. , Navis Gerjan J. , Schroevers Maya J. 
Published: January 2025

AbstractObjectivesPeople with chronic kidney failure (CKF) on dialysis who perceive little control in life are at risk for a reduced well‐being. We developed and tested an intervention aiming to enhance their perceptions of control. To gain insight into patients' care needs and acceptance of the intervention, we examined the prevalence of patients perceiving low control, their characteristics, and their reasons for (not) accepting the intervention.DesignWe consecutively screened 430 people on dialysis on perceived control, with those reporting low control offered to participate in the intervention study.MethodsWe used data of a Randomized Controlled Trial examining the feasibility, acceptability and efficacy of the intervention. Perceived control was assessed with the Pearlin Mastery scale.ResultsAbout half (55%) of the sample perceived low control, particularly those with more comorbidities. Most persons eligible for receiving the intervention did not accept the intervention (89%), especially older persons. Main reasons were experiencing little burden of perceiving low control as well as no need for care to increase perceived control.ConclusionsA significant number of people on dialysis perceived low control in life, yet very few accepted an intervention for regaining a sense of control. In‐depth qualitative research is needed for a more comprehensive understanding of the personal experience and perceived impact of low control on health and well‐being, activities and relationships as well as people's reasons and needs for enhancing a sense of control and attitude towards psychological interventions aiming to enhance perceived control.
Does Economic Policy Uncertainty differ from other uncertainty measures? Replication of Baker, Bloom, and Davis (2016)
Authors: Bae Siye , Jo Soojin , Shim Myungkyu 
Published: January 2025

AbstractThis paper revisits Baker et al.'s (2016) main finding that shows the significant negative impacts of shocks to the Economic Policy Uncertainty index on the US aggregate economic activity. We focus on subsample analyses with sample periods extended to December 2022. We find that shocks to the index do not significantly affect the economy during the period from September 2008 to December 2019, in contrast to significant negative impacts found in the sample ending earlier. Interestingly, this feature is specific to the Economic Policy Uncertainty index, while other popular uncertainty measures retain downward pressures on the economy across all of the subsample periods under examination. Economic Policy Uncertainty again deters economic activity once the COVID‐19 period is included in the sample, implying that the size of shocks and/or the state of the economy may play an additional role for its transmission.
Interferons in myositis: Pathogenesis and therapy
Authors: Tawara Nozomu 
Published: January 2025

AbstractIdiopathic inflammatory myopathies (IIMs), or myositis, are a heterogeneous group of autoimmune diseases affecting skeletal muscle and other organs. Recent research has revealed the important role of interferons (IFNs) in the pathogenesis of IIMs. This review summarizes the three types of IFNs and their functions in the immune system, focusing on their association with different IIM subtypes. Dermatomyositis (DM) is strongly associated with Type I IFNs. In contrast, inclusion body myositis (IBM), polymyositis with mitochondrial pathology (PM‐mito), and anti‐synthetase syndrome (ASyS) are predominantly associated with Type II IFN. This review explores the molecular mechanisms underlying these associations and their impact on muscle function. In addition, the potential of the IFN signaling pathway as a therapeutic target for IIMs will be discussed. Several clinical trials are currently underway or planned that target the IFN pathway using JAK inhibitors and monoclonal antibodies against Type I IFNs. JAK inhibitors have shown promise in treating DM, particularly in refractory cases. However, more research is needed to fully understand their efficacy and safety profiles in IIMs. The review concludes by highlighting the importance of ongoing research in this area and the potential for new targeted therapies in treating IIMs.
Long‐term survival outcomes in young‐onset colorectal cancer: A population‐based cohort study
Authors: Cao Amy M. Y. , Lonne Michael L. R. , Clark David A. 
Published: January 2025

AbstractAimLong‐term survival outcomes in young‐onset colorectal cancer patients are contradictory and inconsistent. Some studies report overall survival to be significantly superior compared with older adults, while others report worse survival. Worldwide, the incidence of young‐onset colorectal cancer has, alarmingly, nearly doubled since the 1990s, in stark contrast to that in those over 50 years of age. Long‐term survival in young‐onset colorectal cancer has not been explored in the Australian population. The aim of this study was to investigate cancer‐specific and overall survival up to 10 years.MethodThis was a retrospective population‐based cohort study. All colorectal cancer diagnoses between 2001 and 2020 in the state of Queensland, Australia were reviewed. Young‐onset colorectal cancer (20–49 years) was compared with late‐onset colorectal cancer (50 years+).ResultsThere were 52 697 adults diagnosed with colorectal cancer in Queensland. Young‐onset colorectal cancer accounted for 7.7% of these. Young‐onset colorectal cancer had a greater proportion of Stage III and IV disease than the late‐onset group (66% vs. 59%, p < 0.001). Despite this, young‐onset colorectal cancer had statistically significant improved overall survival at all time points to 10 years (p < 0.001). Stage‐for‐stage cancer‐specific survival to 10 years was superior in all stages in young‐onset colorectal cancer (p < 0.001).ConclusionBoth stage‐for‐stage cancer‐specific and overall survival were superior in young‐onset colorectal cancer compared with those aged 50 years and above, up to 10 years.
Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery
Authors: Dovč Klemen , Spanbauer Charles , Chiarle Eleonora , Bratina Natasa , Fröhlich‐Reiterer Elke , Potočnik Nejka , Zaharieva Dessi P. , Hropot Tim , Fritsch Maria , Calhoun Peter , Battelino Tadej 
Published: January 2025

AbstractAimsThe aim of this study was to assess postprandial glycaemic outcomes using automated insulin delivery with faster acting insulin aspart (FIA) or standard insulin aspart (SIA) over 4 weeks in youth (aged 10–18 years) with type 1 diabetes.Materials and MethodsWe undertook a secondary analysis of postprandial glycaemic outcomes from a double‐blind, randomised, crossover study comparing FIA to SIA using an investigational version of MiniMed™ 780G. Endpoints included postprandial time in tight range (70–140 mg/dL; TITR), postprandial glucose excursions and peak glucose, and incremental area under curve (iAUC).ResultsThe mean ± SD age of 30 included participants was 15.0 ± 1.7 years, 47% were male, mean HbA1c was 7.5% ± 0.9% (58 ± 9.8 mmol/mol) and the number of meals per day per participant was 3.2 ± 1.2 meals. Overall, the postprandial outcomes were improved with FIA compared with SIA. Mean glucose at the start of the meal was 151 mg/dL in the FIA group and reached a peak glucose of 194 mg/dL, compared with starting level of 151 mg/dL in the SIA group and a peak of 198 mg/dL (difference in excursion: −3.8 mg/dL; 95% confidence interval −5.8 to −1.7; p <0.001). FIA group also had a 1.9% increase in mean TITR (p = 0.02) and a 2.0‐mg/dL decrease in mean iAUC (p = 0.003). Differences in outcomes were the most noticeable for breakfast, meals with a larger amount of carbohydrates (>45 g) and participants with lower insulin‐to‐carbohydrate ratios.ConclusionsFaster insulin formulation with AID improved postprandial glycaemic outcomes and could be a useful therapeutical option in youth with type 1 diabetes that have challenges achieving glycaemic targets.
Impact of time in tight range on all‐cause and cardiovascular mortality in type 2 diabetes: A prospective cohort study
Authors: Cai Jinghao , Liu Jiechen , Lu Jingyi , Ni Jiaying , Wang Chunfang , Chen Lei , Lu Wei , Zhu Wei , Xia Tian , Zhou Jian 
Published: January 2025

AbstractAimsCurrently, there is a lack of evidence regarding time in tight range (TITR) and long‐term adverse outcomes. We aimed to investigate the association between TITR and the risk of all‐cause and cardiovascular mortality among patients with type 2 diabetes.Materials and MethodsA total of 6061 patients with type 2 diabetes were prospectively recruited in a single centre. TITR was measured with continuous glucose monitoring (CGM) at baseline and was defined as the percentage of time in the target glucose range of 3.9–7.8 mmol/L (70–140 mg/dL) during a 24‐h period. Cox proportion hazard regression models were used to examine the association between TITR and the risk of all‐cause and cardiovascular mortality.ResultsDuring a median follow‐up period of 10.9 years, 1898 (31.3%) death events were confirmed, with 689 (11.4%) due to cardiovascular mortality. The restricted cubic spline revealed significant linear relationships between lower TITR and higher risks of all‐cause and cardiovascular mortality (p for linearity <0.01). In the fully adjusted model including glycated haemoglobin A1c, each 10% decrease in TITR was associated with 4% (95% confidence interval, 1.01–1.06) increased risk of all‐cause mortality and 4% (95% confidence interval, 1.00–1.08) increased risk of cardiovascular mortality. Subgroup analyses showed that the linear relationship between TITR and all‐cause mortality risk was sustained in patients with haemoglobin A1c <7.0% and patients with fasting plasma glucose <7.0 mmol/L.ConclusionsLower TITR is associated with an increased risk of all‐cause and cardiovascular mortality in patients with type 2 diabetes, indicating that tight glycaemic control within the physiological range may be crucial for reducing long‐term mortality risk, especially in those with seemingly well‐controlled diabetes.
Understanding Participation in Integrated Youth Mental Health Service Research: Lessons Learned From a Feasibility Study With Jigsaw
Authors: Dhonnagáin Niall Mac , O'Reilly Aileen , O'Brien Gillian , Dooley Barbara 
Published: January 2025

ABSTRACTIntroductionResearch with integrated youth mental health services (IYMHS) has been criticised for low quality, with difficulties in recruiting and retaining participants in studies which can introduce bias. This feasibility study aimed to investigate the “real‐world research” barriers and facilitators to recruitment and retention arising in a longitudinal study with Jigsaw, the National Centre for Youth Mental Health in Ireland, and to provide recommendations for conducting IYMHS research in future.MethodsA qualitative study was conducted to investigate recruitment and retention difficulties. Participants were young people attending Jigsaw (n = 14) and members of clinical staff (n = 29), who provided feedback on facilitators and barriers to recruiting and retaining participants in a wider youth mental health intervention study. Data were collected via online surveys. Content analysis was conducted on the findings.ResultsFacilitators included the prosocial motivation of young people to support others through research, providing incentives for participants, clear communication and information sharing, and the supportive role of parents/guardians. Identified barriers included the timing of recruitment, communication difficulties, gatekeeping, and reluctance to participate in research. Suggestions provided to address barriers in future were integrating research teams into services, addressing communication difficulties, and timing the recruitment of youth participants appropriately.ConclusionWhere possible, IYMHS should conduct research in person in services to improve communication and reduce gatekeeping. In addition, services should consider remunerating participating young people in research and involve parents/guardians when designing research in this context.
Criminal Offending and Incarceration in United States Adults With Early Phase Psychosis and Comorbid Substance Use Disorder
Authors: Webster Kyle D. , Gunter Tracy D. , Vohs Jenifer L. , Breier Alan 
Published: January 2025

ABSTRACTAimStudies have shown that people experiencing early phase psychosis (EPP) are at increased risk for criminal conviction and incarceration. However, there is limited data looking at overall legal burden. To address these gaps in the literature, the goal of this study was to categorise criminal charges and convictions using the United States Federal Bureau of Investigation (FBI) uniform crime reporting (UCR) program, assess frequency of incarcerations, and describe the frequency of substance use disorder (SUD) diagnoses and its relationship to criminal offending and incarceration in a well categorised EPP population.MethodsA sample of 309 adults experiencing EPP were enrolled in a specialty care clinic. The research team expanded upon prior work and collected data from three public databases to identify legal burden in this population.ResultsAlmost 50% (n = 155) of subjects had a history of a criminal charge, 34% (n = 104) of subjects had a history of criminal conviction, and 40% (n = 123) of subjects had at least one incarceration event. The most common typology of criminal offence were crimes against society. Lastly, a dual diagnosis was statistically associated with incarcerations (χ2 = 10.152, p < 0.0011), crimes against society (χ2 = 13.172, p < 0.0002), and crimes against persons (χ2 = 9.136, p < 0.0023).ConclusionsThese data highlight the high legal burden people experiencing EPP face and the need for future work to examine the risks incarceration places on this population. This work also shows the need for specialty care clinics managing EPP to be proficient in treating a dual diagnosis or the need to partner with an appropriate clinic.
Motion Artifact Removal in Functional Near‐Infrared Spectroscopy Based on Long Short‐Term Memory‐Autoencoder Model
Authors: Yang Pan , Wang Junhong , Wang Ting , Li Lihua , Xu Dongjuan , Xi Xugang 
Published: January 2025

ABSTRACTMotion artifact removal is a critical issue in functional near‐infrared spectroscopy (fNIRS) analysis tasks, with traditional methods relying heavily on expert‐based knowledge and optimal selection of model parameters within brain regions. In this paper, we propose a deep learning denoising model based on long short‐term memory (LSTM)‐autoencoder (viz., LSTM‐AE) to reduce motion artifacts. By training a neural network to reconstruct hemodynamic response coupled with neuronal activity, LSTM‐AE achieves positive denoising results on both our synthesized noisy simulated dataset and the real dataset. The LSTM‐AE processes the raw fNIRS in three phases: (1) Morphological feature extraction of the raw fNIRS is conducted through the encoder module. (2) The LSTM module captures temporal correlations between individual samples to enhance features. (3) The decoder module recovers and reconstructs the morphological feature information of fNIRS from the latent space. Finally, clean reconstructed fNIRS is generated at the output layer. We compare our proposed method with existing calibration algorithms for hemodynamic response estimation using the following metrics: mean square error (MSE), Pearson's correlation (R2), signal‐to‐noise ratio (SNR), and percent deviation ratio (PDR). The proposed LSTM‐AE method outperforms conventional methods, demonstrating an improvement in all these metrics. Additionally, the proposed LSTM‐AE method shows statistically significant differences from other motion artifact algorithms in terms of effectiveness (p < 0.01, significance level α = 0.05). This study demonstrates the potential of deep network architectures to remove motion artifacts in fNIRS data.
Prioritizing Brain Health in Youth: Bringing Neuroscience to Society and Informing Policy, Lessons Learnt from the European Brain Council Expert Meeting Held at the Federation of European Neuroscience Societies Forum 2024
Authors: Dickson Suzanne L. , Tracey Irene , Cirulli Francesca , Kas Martien J. H. , Konradsson‐Geuken Åsa , Rostasy Kevin , Kestens Eva , Arango Celso , Mohr Pavel , Balazs Judit , Simon Judit , Weemaes Karolien , Boselli Simone , Hall Jennifer , Asakawa Tasia , Quoidbach Vinciane 
Published: January 2025

ABSTRACTGood brain health plays a significant role in an individual's well‐being and profoundly impacts the collective economy and society. Brain development does not stop at birth, and some aspects continue throughout childhood and adolescence, allowing the full development of cognitive functions. Different determinants related to physical health, healthy environments, safety and security, life‐long learning and social connection as well as access to quality services influence the way our brains develop, adapt and respond to stress and adversity. Ongoing progress in neurobiology and cognitive neuroscience allows the design of better prevention and intervention strategies to help avoid brain deficits and/or limit their impact and maintain brain health. The European Brain Council (EBC) convened an expert meeting during the Federation of European Neuroscience Societies (FENS) Forum 2024 to address youth brain health challenges. In recent years, the importance of brain health has garnered significant attention across scientific, medical and policy‐making communities. Although much focus has traditionally been on neurodegenerative conditions affecting the elderly, a paradigm shift towards prioritizing brain health in youth is both timely and necessary. This shift can profoundly impact individual lives and society, necessitating an interdisciplinary approach that brings neuroscience to the forefront of public health and informs evidence‐based policy. The topic is of utmost importance as EBC launched this year a new campaign on No Health Without Brain Health rallying support with its member organizations and the wider brain community for the increased prioritization of brain health on EU health and research agendas.