bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation and autonomic balance in cirrhosis: Association between sympathetic nervous system and osteopontin, interleukin‐22, interleukin‐6 and interleukin‐1Ra concentrations according to portal hypertension and disease severity
Authors: Miceli Giuseppe , Pennisi Grazia , Agnello Luisa , Calvaruso Vincenza , Amodio Emanuele , Casuccio Alessandra , Pintus Chiara , Basso Maria Grazia , Pipitone Rosaria Maria , Daidone Mario , Zito Rossella , Lupo Giulia , Petta Salvatore , Cabibbo Giuseppe , Ciaccio Marcello , Grimaudo Stefania , CraxÌ Antonio , Tuttolomondo Antonino 
Published: November 2023

AbstractBackgroundThe autonomic nervous system is linked to hyperdynamic circulation in cirrhosis and several studies have highlighted the crucial role that systemic inflammation elicits in altering sympathovagal equilibrium with the consequent reduction in heart rate variability (HRV).To investigate the correlation between time‐domain HRV parameters, serum cytokines concentrations and portal hypertension, we studied a cohort of patients with cirrhosis, accounting for etiology and treatments.MethodsIn this cross‐sectional, observational cohort study, 107 outpatients with non‐alcoholic cirrhosis were assessed consecutively by abdominal ultrasound and by upper gastrointestinal endoscopy to search for esophagogastric varices. 24‐h electrocardiogram Holter monitoring with time‐domain HRV measurement (square root of the mean of successive differences of Normal‐to‐Normal [NN] [RMSSD], standard deviation or the square root of variance [SDNN] and standard deviation of the means of the NN intervals calculated over a 5‐min period [SDANN]) was performed and serum concentrations of osteopontin (OPN), interleukin (IL)‐22, IL‐6, IL‐1Ra and IL‐17 were obtained in all patients.ResultsIL‐6, OPN, IL‐22 and IL‐1Ra concentrations in cirrhotic patients were associated with disease severity expressed by Child‐Pugh and MELD score, to some portal hypertension's indirect signs and some of its complications. A significant increase in systemic concentrations of OPN in patients with hepatocellular carcinoma was encountered. SDANN and SDNN values were indirectly related to serum levels of IL‐6, OPN, IL‐1Ra and IL‐22.ConclusionsThis study underlines the interaction between the alteration of the ANS and the activation of inflammatory pathways that characterize cirrhosis taking into account clinical characteristics and treatments.
Comparison of poisoning deaths with wastewater‐based consumption estimates and assessment of fatal toxicity for amphetamine‐type stimulant drugs
Authors: Kriikku Pirkko , Kankaanpää Aino , Gunnar Teemu , Ojanperä Ilkka 
Published: November 2023

AbstractAmong several established indicators that are used to monitor the illicit drug scene, drug‐related deaths and wastewater‐based epidemiology (WBE) stand out for population‐level coverage. In this study, we aimed to compare temporal trends with respect to amphetamine, methamphetamine and methylenedioxymethamphetamine (MDMA) revealed by these indicators and explore the differences in fatal toxicity between the stimulants. All deaths in which poisoning caused by amphetamine, methamphetamine or MDMA was either the underlying or contributing cause of death in Finland in 2012, 2014, 2016, 2018 and 2020 were included in the study. Consumption of the studied drugs was measured by WBE in the same years. There was a significant correlation between poisoning and drug consumption for all three stimulants, and for amphetamine and MDMA, these figures increased over the study period. The highest fatal toxicity, as expressed by the number of deaths per million doses, was obtained for methamphetamine at an estimated dose of 50 mg, followed by MDMA (100 mg dose) and with amphetamine (50 mg dose). The fatal toxicity found here for the stimulants was close to that previously reported for many prescription opioids and tricyclic antidepressants. Our study is the first to quantitatively investigate the fatal toxicity of amphetamine‐type stimulants by comparing deaths with consumption estimates derived from WBE. It shows that amphetamine, methamphetamine and MDMA possess a quite similar capacity to cause death. This new approach adds to the earlier methods of estimating drug‐related harm.
2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination
Authors: Pastor Ferenc T. , Dojčinović Biljana P. , Kodranov Igor D. , Gorjanović Stanislava Ž. , Ivanović Tijana , Popović Daniela Ž. , Miladinović Jelena 
Published: November 2023

AbstractDue to the similar chemical properties of Ni2+ and Co2+, several dozens of adsorptive stripping voltammetric (AdSV) methods have been developed for their simultaneous determination. The question was would there be some benefits if a stripping method made for simultaneous determination of Ni2+ and Co2+ will be optimized for the determination of only one of them (Ni2+). It was found that the optimized method has for an order of magnitude lower LOQ (1.89×10−10 M), an order of magnitude lower influence of Co2+, and the applicability of one calibration line for four orders of magnitude of Ni2+ concentration. The influence of some common anions and cations has been examined. The developed method was successfully applied for nickel content determination in real samples. The suitability of the developed method for the determination of Co2+ from the same solution in the second run, upon optimizations of deposition potential and time, was also explored. The LOQ obtained for Co2+ (3.61×10−11 M) is almost two orders of magnitude lower than LOQ of the method for simultaneous determination of both cations and, its LOD and LOQ are among few lowest obtained by AdSV methods for Co2+ determination. The developed method for Ni2+ and Co2+ determination from the same solution in two successive runs has significantly better analytical performances than the starting method for their simultaneous determination in one run.
A new state‐of‐health estimation method for Li‐ion batteries based on interpretable belief rule base with expert knowledge credibility
Authors: Yin Xiuxian , Jia Ruxia , Xu Bing , Li Hongyu , Zhu Hailong , He Wei 
Published: November 2023

AbstractState‐of‐health (SOH) estimation methods for Li‐ion batteries are important for the safe operation of the entire system. However, it is often challenging due to the uncertainty within the batteries and the criteria for model interpretability. Belief rule base (BRB) is a rule‐based expert system that has certain advantages for both aspects. However, several problems with BRB interpretability need to be solved urgently. First, expert knowledge credibility is often given subjectively, while objective information is neglected to be considered. Second, BRB interpretability is easily ignored or corrupted in the optimization process. Third, expert knowledge is assumed to be completely reliable information to be used as interpretability evaluation criterion. Therefore, a new SOH estimation method for Li‐ion batteries based on interpretable BRB with expert knowledge credibility (IBRB‐c) is proposed. In the IBRB‐c, the calculation method of expert knowledge credibility is given. Then, an optimization algorithm with interpretability strategies is used. Finally, the concept of the fuzzy interpretable interval is proposed to design the interpretable evaluation criterion. The effectiveness of the proposed method is verified by using the experiment of NASA Li‐ion battery as a case study.
Fortification of dough with moringa, coriander, and amaranth improves the nutritional composition, health‐benefiting properties, and sensory attributes of Nigerian wheat bread
Authors: Oyinloye P. O. , Ajala A. S. , Asogwa N. T. , Galani Y. J. H. 
Published: November 2023

AbstractConsumption of bread can be associated with some health issues, which can be improved by fortifying it with plants that are good sources of nutrients and bioactive compounds. This study investigated the effects of fortifying bread with 3 leafy vegetables on the quality of Nigerian wheat bread. Leave powders of coriander, moringa, and amaranths were added to wheat dough at 0% (control), 1%, 3%, 5%, or 7%, and the blends obtained were used to bake vegetable breads, which were then analyzed for proximate, minerals, total phenolics, antioxidant activity, reducing sugars, glycemic index, and sensory evaluation. Results showed that vegetable fortification significantly increased bread ash (from 0.84% in control up to 1.93% in fortified bread), crude fiber (from 1.68% to 3.29%), and nutritionally important minerals Ca, Mg, P, Fe, and Zn (up to 5.2‐fold, 5.1‐fold, 18.1‐fold, 4.1‐fold, and 14.0‐fold, respectively); it reduced carbohydrates (from 65.65% down to 43.16%), crude lipids (from 2.25% down to 0.44%), and caloric value (from 1239.65 down to 1125.19 kJ/100 g), with little or no effect on proteins and moisture content. The fortification also improved the bioactive properties of the bread, as evidenced by a considerably higher phenolic content (from 0.40 up to 13.95 mg/100 g GAE) and increased antioxidant activities. There was a significant 1.1‐to 3.4‐fold decrease in the reducing sugars of composite breads with 5% and 7% vegetable powder, and the selected bread formulation with Moringa 7% lowered the glycemic index of rats by 3.5‐fold. Fortification did not generally affect the appearance and taste of the breads but decreased other sensory parameters and overall acceptability; the bread sample enriched with 1% amaranth received the highest general acceptance. In conclusion, fortifying wheat bread with the 3 vegetables improves its nutritional quality and can be recommended as a new pathway for the development of more nutritious and healthy bread.
From medical strategy to foodborne prophylactic strategy: Stabilizing dental collagen with aloin
Authors: Jia Chongzhi , Li Hua , Yang Zhongliang , Xu Rongchen , Wang Lijun , Li Hongbo 
Published: November 2023

AbstractInfectious oral diseases are longstanding global public health concerns. However, traditional medical approaches to address these diseases are costly, traumatic, and prone to relapse. Here, we propose a foodborne prophylactic strategy using aloin to safeguard dental collagen. The effect of aloin on the stability of dental collagen was evaluated by treating dentin with a solution containing aloin (0.1 mg/mL) for 2 min. This concentration is comparable to the natural aloin content of edible aloe. Furthermore, we investigated the mechanisms underlying the interactions between aloin and dentin collagen. Our findings, obtained through fluorescence spectroscopy, attenuated total reflection Fourier transform infrared spectroscopy, Gaussian peak fitting, circular dichroism spectroscopy, and X‐ray diffraction, revealed that aloin interacts with dental collagen through noncovalent bonding, specifically hydrogen bonding in situ. This interaction leads to a reduction in the distance between molecules and an increase in the proportion of stable α‐helical chains in the dental collagen. The ultimate tensile strength and thermogravimetric analysis demonstrated that dental collagen treated with aloin exhibited improved mechanical strength and thermostability. Additionally, the release of hydroxyproline, cross‐linked carboxy‐terminal telopeptide of type I collagen, and C‐terminal cross‐linked telopeptide of type I collagen, along with weight loss, indicated an enhancement in the enzymatic stability of dental collagen. These findings suggest that aloin administration could be a daily, nondestructive, and cost‐effective strategy for managing infectious oral diseases.
Mildew detection in rice grains based on computer vision and the YOLO convolutional neural network
Authors: Sun Ke , Tang Mengdi , Li Shu , Tong Siyuan 
Published: November 2023

AbstractAt present, detection methods for rice microbial indicators are usually based on microbial culture or sensory detection methods, which are time‐consuming or require expertise and thus cannot meet the needs of on‐site rice testing when the rice is taken out of storage or traded. In order to develop a fast and non‐destructive method for detecting rice mildew, in this paper, micro‐computer vision technology is used to collect images of mildewed rice samples from 9 image locations. Then, a YOLO‐V5 convolutional neural network model is used to detect moldy areas of rice, and the mold coverage area is estimated. The relationship between the moldy areas and the total number of bacterial colonies in the image is obtained. The results show that the precision and the recall of the established YOLO‐v5 model in identifying the mildewed areas of rice in the validation set were 82.1% and 86.5%, respectively. Based on the mean mildewed area identified by the YOLO‐v5 model, the precision and recall for light mold detection were 100% and 95.3%, respectively. The proposed method based on micro‐computer vision and the YOLO convolutional neural network can be applied to the rapid detection of mildew in rice taken out of storage or traded.
Dietary approach to stop hypertension (DASH), but not Mediterranean and MIND, dietary pattern protects against Parkinson's disease
Authors: Keramati Majid , Kheirouri Sorayya , Etemadifar Masoud 
Published: November 2023

AbstractThe neuroprotective effects of dietary patterns have been reported in previous studies. This study aimed to examine the association between the dietary approach to stop hypertension (DASH), the Mediterranean diet (MeDi), and the Mediterranean‐DASH intervention for neurodegenerative delay (MIND) with the severity and risk of Parkinson's disease (PD). In this comparative cross‐sectional study, 120 patients with PD and 50 healthy participants participated. Adherence to DASH, MeDi, and MIND dietary patterns was determined according to the dietary intake data using a food frequency questionnaire (FFQ). The Severity of PD was determined by the Unified Parkinson's Disease Rating Scale (UPDRS). The mean score of the DASH was significantly lower in the PD group compared to the healthy group (p = .006), but the mean score of MeDi and MIND did not significantly differ between the two groups (p > .05). Also, the mean score of the DASH was significantly lower in men than in women in the healthy group (p = .018). High adherence to the DASH diet decreased the risk of PD by 15% (OR = 0.856, 95% CI: 0.751, 0.976, p = .020). Participants in quartiles 3 and 4 of the DASH dietary pattern had 86% (p = .003) and 87% (p = .007), respectively, lower risk of PD. MeDi and MIND diets were not significantly associated with the risk of PD. There was no significant association between dietary patterns and the severity of PD. The findings indicate that high adherence to the DASH dietary pattern may protect against PD.
Signaling pathways regulating the immune function of cochlear supporting cells and their involvement in cochlear pathophysiology
Authors: Hayashi Yushi 
Published: November 2023

AbstractThe inner ear, including the cochlea, used to be regarded as an immune‐privileged site because of its immunologically isolated environment caused by the blood‐labyrinthine barrier. Cochlear resident macrophages, which originate from the yolk sac or fetal liver during the embryonic stage and are maintained after birth, are distributed throughout various regions of the cochlear duct. Intriguingly, these cells are absent in the organ of Corti, where hair cells (HCs) and supporting cells (SCs) are located, except for a limited number of ionized calcium‐binding adapter molecule 1 (Iba1)‐positive cells. Instead, SCs exert glial functions varying from a quiescent to an emergency state. Notably, SCs acquire the nature of macrophages and begin to secrete inflammatory cytokines during viral infection in the organ of Corti, which is ostensibly unprotected owing to the lack of general resident macrophages. This review provides an overview of both positive and negative functions of SCs enabled to acquire macrophage phenotypes upon viral infection focusing on the signaling pathways that regulate these functions. The former function protects HCs from viral infection by inducting type I interferons, and the latter function induces HC death by necroptosis, leading to sensorineural hearing loss. Thus, SCs play contradictory roles as immune cells with acquired macrophage phenotypes; thereby, they are favorable and unfavorable to HCs, which play a pivotal role in hearing function.
Sentinel lymph node biopsy for head and neck malignancies utilizing simultaneous radioisotope gamma probe and indocyanine green fluorescence navigation
Authors: Sethi Harleen K. , Sina Elliott M. , Mady Leila J. , Fundakowski Christopher E. 
Published: November 2023

AbstractWe depict an innovative surgical approach for sentinel lymph node biopsy (SLNB) in head and neck malignancies that utilizes both near‐infrared (NIR) imaging with indocyanine green (ICG) dye and hand‐held gamma probe intraoperatively to isolate and excise SLNs. Twenty‐one patients presented to our institution with cutaneous melanoma, cutaneous squamous cell carcinoma (SCC), and oral cavity SCC tumors that met criteria for SLNB based on tumor depth and histology. The video offers a step‐by‐step approach for this technique along with descriptions of recommended equipment. Among 21 patients, two patients had positive SLNs on final pathology. One patient developed a local recurrence over an average of 16.2 months of follow‐up (SD = 15.6). SLNB with ICG and radionucleotide co‐localization may enhance the identification of sentinel nodes without compromising outcomes in the hands of surgeons well‐versed in the technique.
Undergraduate enrollment intentions and willingness‐to‐pay for online to in‐person teaching modalities: Capturing heterogeneity across and within universities in the United States during the pandemic
Authors: Bergtold Jason S. , Penn Jerrod , Boys Kathryn A. , Kiesel Kristin , Ehmke Mariah D. , Katare Bhagyashree 
Published: November 2023

AbstractThis study analyzes undergraduate students' enrollment intentions and preferences for alternate teaching modalities during the pandemic under a range of reopening scenarios and flexible teaching modalities to investigate the value of flexible learning options and campus life offerings for students. Using primary survey data from six land‐grant universities, our findings suggest that there is no one‐size‐fits‐all policy for tackling significant shocks like the pandemic. Business‐as‐usual was the most divisive, with wide differences in preferences both within and across universities. These results have important implications for future responses to major disruptions in higher education.
Using behavioral economics to optimize safer undergraduate late‐night transportation
Authors: Gelino Brett W. , Graham Madison E. , Strickland Justin C. , Glatter Hannah W. , Hursh Steven R. , Reed Derek D. 
Published: November 2023

AbstractMany universities sponsor student‐oriented transit services that could reduce alcohol‐induced risks but only if services adequately anticipate and adapt to student needs. Human choice data offer an optimal foundation for planning and executing late‐night transit services. In this simulated choice experiment, respondents opted to either (a) wait an escalating delay for a free university‐sponsored “safe” option, (b) pay an escalating fee for an on‐demand rideshare service, or (c) pick a free, immediately available “unsafe” option (e.g., ride with an alcohol‐impaired driver). Behavioral‐economic nonlinear models of averaged‐choice data describe preference across arrangements. Best‐fit metrics indicate adequate sensitivity to contextual factors (i.e., wait time, preceding late‐night activity). At short delays, students preferred the free transit option. As delays extend beyond 30 min, most students preferred competing alternatives. These data depict a policy‐relevant delay threshold to better safeguard undergraduate student safety.
Therapeutic properties, biological effects, antiliver cancer, and anticolon cancer effects of some natural compounds: A biochemical approach
Authors: Li Long , Zhu Yu , Huang Ying‐Guang , Hou De‐Zhi , Ahmed Zaki Mohamed Samir , Sideeg Abulqasim M. , Mohammed Heitham , El‐kott Attalla F. , Al‐Saeed Fatimah A. , Ling Ping 
Published: November 2023

AbstractNatural compounds, such as carotenoids, flavonoids, anthocyanins, or terpenoids, are physiologically active components found in plants (pigments), often known as phytochemicals or phytonutrients. The in vitro cytotoxic and anticolon cancer effects of biologically bavachin, bavachinin, artepillin C, and aromadendrin compounds against SW48, SNU‐C1, COLO 205, RKO, LS411N, and SW1417 cancer cell lines were assessed. Results of enzymes and antibacterial, antifungal were in level of micromolar that is good impacts. These natural compounds may be antidiabetic, anticancer, and antibacterial candidates for drug design. IC50 results were obtained between 14–19 and 5–119 µM for α‐amylase and α‐glucosidase, respectively. Good inhibitor Bavachinin was detected for both enzymes (IC50 for α‐amylase: 14.37 µM and IC50 for α‐glucosidase: 5.27 µM). The chemical activities of aromadendrin, artepillin C, bavachin, and bavachinin against pancreatic α‐amylase and α‐glucosidase were assessed by conducting the molecular docking study. The chemical activities of aromadendrin, artepillin C, bavachin, and bavachinin against some of the expressed surface receptor proteins (CD44, CD47, CXCR4, EGFR, folate receptor, HER2, and endothelin receptor) in the mentioned cell lines were investigated using the molecular docking calculations. The results illustrated the atomic‐level properties and potential interactions. These chemicals have high binding affinities to the enzymes and proteins, according to the docking scores. In addition, the compounds formed strong contacts with the enzymes and receptors. Thus, these compounds could be potential inhibitors for enzymes and cancer cells.
Silencing of GDF11 suppresses hepatocyte apoptosis to relieve LPS/D‐GalN acute liver failure
Authors: Zhou Rongsheng , Li Shuang , Wang Qun , Bi Yang , Li Xiaogang , Wang Qiang 
Published: November 2023

AbstractIn this paper, we generated a short hairpin RNA growth differentiation factor‐11 (sh‐GDF11) and evaluated the effects of sh‐GDF11 on the pathogenesis of acute liver failure (ALF) in vitro and in vivo. Through bioinformatics study, the key gene related to ALF was assayed. Lipopolysaccharide (LPS) and D‐galactoamine (D‐GalN) were applied to establish the mouse model of LPS/D‐GalN‐induced liver injury, and TNF‐α and D‐Gal were used to construct an in vitro cell model, followed by treatment of sh‐GDF11 for analysis of liver cell proliferation. Bioinformatics analysis showed that the protective effect of sh‐GDF11 on ALF may be mediated by phosphatidylinositol‐3‐kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway. The results of in vitro study found that sh‐GDF11 could promote cell proliferation and inhibit death by blocking the PI3K/Akt/mTOR signaling pathway. In vivo animal experiments further confirmed that sh‐GDF11 could suppress hepatocyte apoptosis by inhibiting the PI3K/Akt/mTOR signaling pathway. sh‐GDF11 relieved LPS/D‐GalN‐induced ALF by blocking the PI3K/Akt/mTOR signaling pathway, emphasizing its critical role in LPS/D‐GalN‐induced ALF treatment.