bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imputation of Missing Data for Time-to-Event Endpoints Using Retrieved Dropouts
Authors: Wang Shuai , Frederich Robert , Mancuso James P. 
Published: October 2023

AbstractWe have explored several statistical approaches to impute missing time-to-event data that arise from outcome trials with relatively long follow-up periods. Aligning with the primary estimand, such analyses evaluate the robustness of results by imposing an assumption different from censoring at random (CAR). Although there have been debates over which assumption and which method is more appropriate to be applied to the imputation, we propose to use the collection of retrieved dropouts as the basis of missing data imputation. As retrieved dropouts share a similar disposition, such as treatment discontinuation, with subjects who have missing data, they can reasonably be assumed to characterize the distribution of time-to-event among subjects with missing data. In terms of computational intensity and robustness to violation of underlying distributional assumption, we have compared parametric approaches via MCMC or MLE multivariate sampling procedures to a non-parametric bootstrap approach with respect to baseline hazard function. Each of these approaches follows a process of multiple imputation (“proper imputations”), analysis of complete datasets, and final combination. The type-I error, and power rates are examined under a wide range of scenarios to inform the performance characteristics. A subset of a real unblinded phase III CVOT is used to demonstrate the application of the proposed approaches, compared to the Cox proportional hazards model and jump-to-reference multiple imputation.
An Analysis of the Social Impacts of a Health System Strengthening Program Based on Purchasing Health Services
Authors: Tchouaket Eric , Karemere Hermes , Sia Drissa , Kapiteni Woolf 
Published: October 2023

AbstractAccess to universal health coverage is a fundamental right that ensures that even the most disadvantaged receive health services without financial hardship. The Democratic Republic of Congo is among the poorest countries in the world, yet healthcare is primarily made by direct payment which renders care inaccessible for most Congolese. Between 2017 and 2021 a purchasing of health services initiative (Le Programme de Renforcement de l’Offre et Développement de l’accès aux Soins de Santé or PRO DS), was implemented in Kongo Central and Ituri with the assistance of the non-governmental organization Memisa Belgium. The program provided funding for health system strengthening that included health service delivery, workforce development, improved infrastructure, access to medicines and support for leadership and governance. This study assessed the social and health impacts of the PRO DS Memisa program using a health impact assessment focus. A documentary review was performed to ascertain relevant indicators of program effect. Supervision and management of health zones and health centers, use of health and nutritional services, the population’s nutritional health, immunization levels, reproductive and maternal health, and newborn and child health were measured using a controlled longitudinal model. Positive results were found in almost all indicators across both provinces, with a mean proportion of positive effect of 60.8% for Kongo Central, and 70.8% in Ituri. Barriers to the program’s success included the arrival of COVID-19, internal displacement of the population and resistance to change from the community. The measurable positive impacts from the PRO DS Memisa program reveal that an adequately funded multi-faceted health system strengthening program can improve access to healthcare in a low-income country such as the Democratic Republic of Congo.
Taniwha, taonga, and tangata
Authors: Watene Krushil 
Published: October 2023

AbstractThis comment draws on Paul Tapsell’s work on taonga to help make explicit some of what I take to be working behind Dan Hikuroa’s writings on taniwha and thus Justine Kingsbury’s Taniwha project. I detail some of the insights that a more detailed and complex account of taniwha—one that is framed around taniwha and taonga relationships—can provide. I contend that understanding taniwha in relation to taonga helps to highlight the way that Kingsbury’s account necessarily lacks elements essential to taniwha themselves and essential to their relationships with taonga. On the back of this contention, one conclusion we come to is that Kingsbury merely offers us a way of taking some aspects of taniwha seriously. Another, and perhaps more important conclusion, is that our discussion of taniwha and taonga provides us with a way to recast Kingsbury’s project—allowing us to take as our focus (and thereby value) relationships between taniwha, taonga, and tangata. One upshot is a framework for thinking about what is required to enable deeper and harder conversations later on that are framed in relational terms too. This, I argue, might not only be a more fruitful approach, but one more in line with Kingsbury’s aspirations.
“Metropollage”: on innovating the Shanghai metropolitan rural revitalization model
Authors: Yang Guiqing 
Published: October 2023

AbstractIn response to the newly published “the 14th Five-year” Plan for Rural Revitalization of Shanghai Municipality, this article looks into the background and transformation of functions of rural revitalization in the Shanghai metropolis, and puts forward policy suggestions to supplement the current model of rural demolishing and reorganization, and relatively concentrated rural living. Hence the author created the concept of “Metropollage” and its development model; and analyzed the three stages of “Metropollage” development, i.e., the prelude, the enhancement and the maturation, along with their respective key characteristics and operational undertakers, among aspects discussed. This article provides theoretical thinking and exploration into the model of innovative paths for a metropolis to implement the National Rural Revitalization Strategy.
Observational Study of Self-Reported Offshore Sailing-Related Injuries in a Wide Range of Amateur and Professional Sailors
Authors: Forycka Joanna , Wojtowicz Julia , Kolodziejczyk Kornelia , Lesman Jedrzej , Mostowy Marcin 
Published: October 2023

Introduction Offshore sailing yields injury risk. Unfortunately, many studies are restricted to a specific geographic location, regatta, or class of sailboat or to only professional sailors. Therefore, the primary aim of this study was to gather a large database of sailing-related injuries with demographic, injury, and voyage characteristics. Methods An observational study of self-reported offshore sailing-related injuries was performed using an internet-based, multiple-choice survey distributed on social media. Data were analyzed statistically with the use of the Shapiro-Wilk test, Mann-Whitney U test, and χ2 test. Results Five hundred sixty-eight people completed the survey, 217 women and 351 men, with a mean age of 36.26 y (SD=13.69 y). Among reported 793 cruises, 141 resulted in injury (18%). The most frequent injury types were contusion (40%) and skin lesions and lacerations (20%); the most frequent locations were hand (28%) and foot and ankle (18%), and the most frequent mechanisms were tripping/falling (33%), being hit by an object (19%), and using ropes (19%). Sex, age, and sailing experience were not injury risk factors, while higher number of offshore days was ( P=0.0004). None of the analyzed voyage characteristics (purpose, ship’s class, position on the ship, ship’s length overall, type of rigging, and harness wearing) were injury risk factors. Sailors perceived the following as risk factors: inattention/distraction (34%), difficult weather conditions (22%), and fatigue/lack of sleep (14%). Conclusions Approximately 1 in 5 cruises resulted in an injury, occurring regardless of demographic, injury, and voyage characteristics. The multifactorial nature of injuries poses a challenge in implementing safety measures. The authors hope that this study may aid in that cause.
Fire‐Pollutant‐Atmosphere Components and Its Impact on Mortality in Portugal During Wildfire Seasons
Authors: de Souza Fernandes Duarte Ediclê , Salgueiro Vanda , Costa Maria João , Lucio Paulo Sérgio , Potes Miguel , Bortoli Daniele , Salgado Rui 
Published: October 2023

AbstractThis study analyzed fire‐pollutant‐meteorological variables and their impact on cardio‐respiratory mortality in Portugal during wildfire season. Data of burned area, particulate matter with a diameter of 10 or 2.5 μm (μm) or less (PM10, PM2.5), carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), temperature, relative humidity, wind speed, aerosol optical depth and mortality rates of Circulatory System Disease (CSD), Respiratory System Disease (RSD), Pneumonia (PNEU), Chronic Obstructive Pulmonary Disease, and Asthma (ASMA), were used. Only the months of 2011–2020 wildfire season (June–July–August–September‐October) with a burned area greater than 1,000 ha were considered. Principal component analysis was used on fire‐pollutant‐meteorological variables to create two indices called Pollutant‐Burning Interaction (PBI) and Atmospheric‐Pollutant Interaction (API). PBI was strongly correlated with the air pollutants and burned area while API was strongly correlated with temperature and relative humidity, and O3. Cluster analysis applied to PBI‐API divided the data into two Clusters. Cluster 1 included colder and wetter months and higher NO2 concentration. Cluster 2 included warmer and dried months, and higher PM10, PM2.5, CO, and O3 concentrations. The clusters were subjected to Principal Component Linear Regression to better understand the relationship between mortality and PBI‐API indices. Cluster 1 showed statistically significant (p‐value < 0.05) correlation (r) between RSDxPBI (rRSD = 0.58) and PNEUxPBI (rPNEU = 0.67). Cluster 2 showed statistically significant correlations between RSDxPBI (rRSD = 0.48), PNEUxPBI (rPNEU = 0.47), COPDxPBI (rCOPD = 0.45), CSDxAPI (rCSD = 0.70), RSDxAPI (rCSD = 0.71), PNEUxAPI (rPNEU = 0.49), and COPDxAPI (rPNEU = 0.62). Cluster 2 analysis indicates that the warmest, driest, and most polluted months of the wildfire season were associated with cardio‐respiratory mortality.
Methods of Assessing Health Care Costs in a Changing Climate: A Case Study of Heatwaves and Ambulance Dispatches in Tasmania, Australia
Authors: Campbell Sharon L. , Remenyi Tomas , Johnston Fay H. 
Published: October 2023

AbstractAnthropogenic climate change is causing a rise in global temperatures, with this trend projected to increase into the future. Rising temperatures result in an increase in the frequency and severity of heatwave events, with an associated increase in poor health outcomes for vulnerable individuals. This places an increasing strain on health care services. However, methods calculating future health care costs associated with this trend are poorly understood. We calculated health care costs attributable to heatwave events in Tasmania 2009–2019, using ambulance dispatches as a case study. We also modeled the expected health and economic burden for projected heatwave frequencies between 2010 and 2089. We developed our models based on two possible approaches to describing population adaptation to heatwaves—an adapted population calculated by determining heatwave episodes using a rolling baseline, and a non‐adapted population calculated by determining heatwave episodes using a static baseline. Using a rolling baseline calculation for 2010 to 2089, we estimated additional ambulance costs averaging AUD$57,147 per year and totaling AUD$4,571,788. For the same period using a static baseline, we estimated additional ambulance costs averaging AUD$517,342 per year and totaling AUD$41,387,349. While this method is suitable for estimating the health care costs associated with heatwaves, it could be utilized for estimating health care costs related to other climate‐related extreme events. Different methods of estimating heatwaves, modeling an adapted versus non‐adapted population, provide substantial differences in projected costs. There is potential for considerable health system cost savings when a population is supported to adapt to extreme heat.
The Role of Interactive Soil Moisture in Land Drying Under Anthropogenic Warming
Authors: Zhou Wenyu , Leung L. Ruby , Lu Jian 
Published: October 2023

AbstractRelative humidity (RH) is projected to increase over ocean but decrease over land under anthropogenic warming. The land RH decrease was previously attributed to ocean influences on land changes. Here, we show that interactive soil moisture (SM) is necessary and may be sufficient for anthropogenic warming to reduce the land RH. The land RH decrease is absent in simulations with realistic land‐ocean geometry but fixed SM, and present in simulations with interactive SM but no oceans or changes in precipitation minus evaporation. The land RH decrease is coupled to the SM decline and the latter could be understood as a natural response of interactive SM to anthropogenic warming. Specifically, prior to adjustments in SM and RH, evaporation would increase by ∼6% K−1 following the Clausius–Clapeyron relation, outpacing the radiatively constrained ∼2% K−1 precipitation increase. This prior imbalance depletes SM and consequently reduces RH through the coupling between SM and RH.
Quantifying the Absorption Loss of Radiation Belt Energetic Particles by Saturn's Inner Moons
Authors: Wang Shaobei , Si Chaoyue , Long Minyi , Lu Peng , Cao Xing , Ni Binbin , Yang Guanglei 
Published: October 2023

AbstractSaturn owns various moons embedded in the magnetosphere, which results in the absorption loss of energetic particles in Saturn's radiation belts when they encounter the body of moons. In the present study, we perform a quantitative analysis of radiation belt energetic electron and proton lifetimes due to the absorption loss by five of inner moons of Saturn (Mimas, Enceladus, Tethys, Dione, and Rhea). Our results show that the resultant averaged lifetimes of energetic particles generally range from ∼0.01 days to infinity, depending strongly on particle energy, equatorial pitch angle, and moon orbit. The averaged lifetimes of energetic electrons increase with increasing electron energy at energies of <1 MeV and peak at the resonance energy, at which the electron drift velocities approach the Kepler velocities of moons. For >1 MeV electrons, the corresponding electron lifetimes decrease as electron energy increases. The averaged lifetimes of protons decrease monotonically with increasing equatorial pitch angles and kinetic energies. We find that the absorption loss by Tethys is the strongest, with the corresponding electron lifetimes shorter than 1 day and the corresponding proton lifetimes shorter than 10 days. The moon absorption effects due to Mimas are the weakest. Our results of energetic particle lifetimes due to the absorption loss by Saturn's moons can be incorporated into future modeling efforts of the radiation belt particle dynamics at Saturn.
Accelerating Large‐Eddy Simulations of Clouds With Tensor Processing Units
Authors: Chammas Sheide , Wang Qing , Schneider Tapio , Ihme Matthias , Chen Yi‐fan , Anderson John 
Published: October 2023

AbstractClouds, especially low clouds, are crucial for regulating Earth's energy balance and mediating the response of the climate system to changes in greenhouse gas concentrations. Despite their importance for climate, they remain relatively poorly understood and are inaccurately represented in climate models. A principal reason is that the high computational expense of simulating them with large‐eddy simulations (LES) has inhibited broad and systematic numerical experimentation and the generation of large data sets for training parametrization schemes for climate models. Here we demonstrate LES of low clouds on tensor processing units (TPUs), application‐specific integrated circuits that were originally developed for machine learning applications. We show that TPUs in conjunction with tailored software implementations can be used to simulate computationally challenging stratocumulus clouds in conditions observed during the Dynamics and Chemistry of Marine Stratocumulus (DYCOMS) field study. The TPU‐based LES code successfully reproduces clouds during DYCOMS and opens up the large computational resources available on TPUs to cloud simulations. The code enables unprecedented weak and strong scaling of LES, making it possible, for example, to simulate stratocumulus with 10× speedup over real‐time evolution in domains with a 34.7 km × 53.8 km horizontal cross section. The results open up new avenues for computational experiments and for substantially enlarging the sample of LES available to train parameterizations of low clouds.
Snapshot Mueller spectropolarimeter imager
Authors: Dai Tianxiang , Phan Thaibao , Wang Evan W. , Kwon Soonyang , Son Jaehyeon , Lee Myungjun , Fan Jonathan A. 
Published: October 2023

AbstractWe introduce an imaging system that can simultaneously record complete Mueller polarization responses for a set of wavelength channels in a single image capture. The division-of-focal-plane concept combines a multiplexed illumination scheme based on Fourier optics together with an integrated telescopic light-field imaging system. Polarization-resolved imaging is achieved using broadband nanostructured plasmonic polarizers as functional pinhole apertures. The recording of polarization and wavelength information on the image sensor is highly interpretable. We also develop a calibration approach based on a customized neural network architecture that can produce calibrated measurements in real-time. As a proof-of-concept demonstration, we use our calibrated system to accurately reconstruct a thin film thickness map from a four-inch wafer. We anticipate that our concept will have utility in metrology, machine vision, computational imaging, and optical computing platforms.
Muscle-inspired soft robots based on bilateral dielectric elastomer actuators
Authors: Yang Yale , Li Dengfeng , Sun Yanhua , Wu Mengge , Su Jingyou , Li Ying , Yu Xinge , Li Lu , Yu Junsheng 
Published: October 2023

AbstractMuscle groups perform their functions in the human body via bilateral muscle actuation, which brings bionic inspiration to artificial robot design. Building soft robotic systems with artificial muscles and multiple control dimensions could be an effective means to develop highly controllable soft robots. Here, we report a bilateral actuator with a bilateral deformation function similar to that of a muscle group that can be used for soft robots. To construct this bilateral actuator, a low-cost VHB 4910 dielectric elastomer was selected as the artificial muscle, and polymer films manufactured with specific shapes served as the actuator frame. By end-to-end connecting these bilateral actuators, a gear-shaped 3D soft robot with diverse motion capabilities could be developed, benefiting from adjustable actuation combinations. Lying on the ground with all feet on the ground, a crawling soft robot with dexterous movement along multiple directions was realized. Moreover, the directional steering was instantaneous and efficient. With two feet standing on the ground, it also acted as a rolling soft robot that can achieve bidirectional rolling motion and climbing motion on a 2° slope. Finally, inspired by the orbicularis oris muscle in the mouth, a mouthlike soft robot that could bite and grab objects 5.3 times of its body weight was demonstrated. The bidirectional function of a single actuator and the various combination modes among multiple actuators together allow the soft robots to exhibit diverse functionalities and flexibility, which provides a very valuable reference for the design of highly controllable soft robots.
CTNNBIP1-CLSTN1 functions as a housekeeping chimeric RNA and regulates cell proliferation through SERPINE2
Authors: Chen Chen , Qin Fujun , Singh Sandeep , Tang Yue , Li Hui 
Published: October 2023

AbstractThe conventional understanding that chimeric RNAs are unique to carcinoma and are the products of chromosomal rearrangement is being challenged. However, experimental evidence supporting the function of chimeric RNAs in normal physiology is scarce. We decided to focus on one particular chimeric RNA, CTNNBIP1-CLSTN1. We examined its expression in various tissues and cell types and compared it quantitatively among cancer and noncancer cells. We further investigated its role in a panel of noncancer cells and investigated the functional mechanism. We found that this fusion transcript is expressed in almost all tissues and a wide range of cell types, including fibroblasts, epithelial cells, stem cells, vascular endothelial cells, and hepatocytes. In addition, the CTNNBIP1-CLSTN1 expression level in noncancerous cell lines was not evidently different from that in cancer cell lines. Furthermore, in at least three cell types, silencing CTNNBIP1-CLSTN1 significantly reduced the cell proliferation rate by inducing G2/M arrest and apoptosis. Importantly, rescue experiments confirmed that cell cycle arrest was restored by exogenous expression of the chimera but not the wild-type parental gene. Further evidence is provided that CTNNBIP1-CLSTN1 regulates cell proliferation through SERPINE2. Thus, CTNNBIP1-CLSTN1 is an example of a new class of fusion RNAs, dubbed “housekeeping chimeric RNAs”.
Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness
Authors: Galai Geut , He Xie , Rotblat Barak , Pilosof Shai 
Published: October 2023

AbstractCancer cells alter the expression levels of metabolic enzymes to fuel proliferation. The mitochondrion is a central hub of metabolic reprogramming, where chaperones service hundreds of clients, forming chaperone-client interaction networks. How network structure affects its robustness to chaperone targeting is key to developing cancer-specific drug therapy. However, few studies have assessed how structure and robustness vary across different cancer tissues. Here, using ecological network analysis, we reveal a non-random, hierarchical pattern whereby the cancer type modulates the chaperones’ ability to realize their potential client interactions. Despite the low similarity between the chaperone-client interaction networks, we highly accurately predict links in one cancer type based on another. Moreover, we identify groups of chaperones that interact with similar clients. Simulations of network robustness show that this group structure affects cancer-specific response to chaperone removal. Our results open the door for new hypotheses regarding the ecology and evolution of chaperone-client interaction networks and can inform cancer-specific drug development strategies.
Warming-induced contraction of tropical convection delays and reduces tropical cyclone formation
Authors: Zhang Gan 
Published: October 2023

AbstractThe future risk of tropical cyclones (TCs) strongly depends on changes in TC frequency, but models have persistently produced contrasting projections. A satisfactory explanation of the projected changes also remains elusive. Here we show a warming-induced contraction of tropical convection delays and reduces TC formation. This contraction manifests as stronger equatorial convection and weaker off-equatorial convection. It has been robustly projected by climate models, particularly in the northern hemisphere. This contraction shortens TC seasons by delaying the poleward migration of the intertropical convergence zone. At seasonal peaks of TC activity, the equatorial and off-equatorial components of this contraction are associated with TC-hindering environmental changes. Finally, the convection contraction and associated warming patterns can partly explain the ensemble spread in projecting future TC frequency. This study highlights the role of convection contraction and provides motivation for coordinated research to solidify our confidence in future TC risk projections.