bluuebunny/crossref_metadata_2025_split huggingface dataset:
SMART-КОНЦЕПЦІЯ ІННОВАЦІЙНОГО ПРОСТОРОВОГО РОЗВИТКУ: ДОСВІД РОЗВИНУТИХ КРАЇН
Authors: БУДНІКЕВИЧ Ірина , ЗАБЛОДСЬКА Інна , БАСТРАКОВ Данііл 
Published: February 2024

В статті досліджено світовий досвід формування та впровадження Smart-концепції інноваційного просторового розвитку. Досліджено компоненти та індикатори Європейської моделі «Розумне місто» та визначено основі індикатори: «відкритий», «інноваційний», «розумний». Подано приклади реалізації інноваційної моделі «Розумне місто» в різних країнах світу. Досліджено досвід створення та функціонування розумних міст в Норвегії, Фінляндії, Данії, Швеції, Канаді, США та інших розвинутих країнах. Визначено основні сучасні акценти «розумних міст»: використання нових технологій, цифрових рішень на благо його жителів і бізнесу, нових технічних рішень у сфері електропостачання, водопостачання, обліку ресурсів, утилізації відходів, а також створення ефективної транспортної системи та будівництво так званих «розумних» будівель, телекомунікацій, супутникового зв'язку, супутникових систем високошвидкісної передачі даних, блокчейн-технологій, світлодіодні технології, проектів пов'язаних з охолодженням, озелененням, парковими зонами, а в північних містах із освітленням, забезпеченням тепла, турботою про екологію та спілкування між людьми тощо. Відзначено, що в Україні вже впроваджуються деякі елементи «розумного міста» як концепції інноваційної трансформації просторового розвитку: інтелектуальні світлофори, автоматизація контролю трафіку транспорту, відеоспостереження та міні-станції вимірювання концентрації шкідливих речовин, формування міської ідентичності та конструювання «бренду» міста/регіону, залучення мега-подій наукового, інноваційного, знаннєвого спрямування тощо. Зроблено висновок, що метою реалізації smart-концепції інноваційного просторового розвитку є відкритість, взаємодія, формування довготривалих взаємовигідних партнерських відносин. Акцентовано, що ресурси взаємодії є саме тим актив, який дозволяє органам місцевого самоврядування трансформувати свій розвиток в інноваційну концепцію, налагодити партнерські відносини між органами місцевого самоврядування та усіма цільовими аудиторіями, організувати захист інтересів стейкхолдерів, залучити самих громадян до фінансування програм розвитку свого міста чи регіону, ефективного використання місцевих ресурсів і формування місцевої інфраструктури.
Expert Insights from a Delphi-driven Neurologists’ Panel: Real-world Mexiletine use in Patients with Myotonic Disorders in Italy
Authors: Lidonnici Dario , Brambilla Pietro , Ravasio Roberto , Zozulya-Weidenfeller Alla , Beiderbeck Annette , van Aswegen Mariska , Oliveira Rosa , Sansone Valeria A. 
Published: February 2024

Background: Myotonic disorders, such as non-dystrophic myotonias (NDMs) and myotonic dystrophies (DMs) are characterized by a delay in muscle relaxation after a contraction stimulus. There is general consensus that protocols to treat myotonia need to be implemented. Objective: Mexiletine is the only pharmacological agent approved for the symptomatic treatment of myotonia in adult patients with NDM and is considered to be the first-line treatment for DMs; however, its production in Italy was halted in 2022 making its availability to patients problematic. Methods: A panel of 8 Italian neurologists took part in a two-round Delphi panel between June and October 2022, analyzing the current use of mexiletine in Italian clinical practice. Results: The panelists assist 1126 patients (69% DM type1, 18% NDM and 13% DM type2). Adult NDM patients receive, on average, 400–600 mg of mexiletine hydrochloride (HCl) while adult DM patients receive 100–600 mg, per day in the long-term. The severity of symptoms is considered the main reason to start mexiletine treatment for both NDM and DM patients. Mexiletine is reckoned to have a clinical impact for both NDM and DM patients, but currently drug access is problematic. Conclusions: Mexiletine treatment is recognized to have a role in the reduction of the symptomatic burden for NDM and DM patients. Patient management could be improved by facilitating access to therapy and developing new drug formulations.
Cross-sectional analysis of risk factors associated with Mugil cephalus in retail fish markets concerning methicillin-resistant Staphylococcus aureus and Aeromonas hydrophila
Authors: Attia Amira S. A. , Abou Elez Rasha M. M. , El-Gazzar Nashwa , Elnahriry Shimaa S. , Alfifi Ahmed , Al-Harthi Helal F. , Alkhalifah Dalal Hussien M. , Hozzein Wael N. , Diab Hassan Mohmoud , Ibrahim Doaa 
Published: February 2024

IntroductionAeromonas hydrophila and methicillin-resistant Staphylococcus aureus (MRSA) are potent bacterial pathogens posing major hazards to human health via consuming fish harboring these pathogens or by cross-contamination beyond the contaminated environment. The aim of this study was to determine risk variables associated with the presence of certain pathogenic bacteria from Mugil cephalus fish in retail markets in Egypt. The virulence genes of A. hydrophila and S. aureus were also studied. Furthermore, the antibiotic sensitivity and multidrug resistance of the microorganisms were evaluated.MethodsIn a cross-sectional investigation, 370 samples were collected from mullet skin and muscle samples, washing water, fish handlers, knives, and chopping boards. Furthermore, fish handlers’ public health implications were assessed via their response to a descriptive questionnaire.ResultsS. aureus and Aeromonas species dominated the investigated samples with percentages of 26.76% and 30.81%, respectively. Furthermore, A. hydrophila and MRSA were the predominant recovered bacterial pathogens among washing water and knives (53.85% and 46.66%, respectively). The virulence markers aerA and hlyA were found in 90.7% and 46.5% of A. hydrophila isolates, respectively. Moreover, the virulence genes nuc and mec were prevalent in 80% and 60% of S. aureus isolates, respectively. Antimicrobial susceptibility results revealed that all A. hydrophila isolates were resistant to amoxicillin and all MRSA isolates were resistant to amoxicillin and ampicillin. Remarkably, multiple drug resistance (MDR) patterns were detected in high proportions in A. hydrophila (88.37%) and MRSA (100%) isolates. The prevalence of Aeromonas spp. and S. aureus had a positive significant correlation with the frequency of handwashing and use of sanitizer in cleaning of instruments. MRSA showed the highest significant prevalence rate in the oldest age category.ConclusionThe pathogenic bacteria recovered in this study were virulent and had a significant correlation with risk factors associated with improper fish handling. Furthermore, a high frequency of MDR was detected in these pathogenic bacteria, posing a significant risk to food safety and public health.
Application of a modified clinical classification for pulmonary arterial hypertension associated with congenital heart disease in children: emphasis on atrial septal defects and transposition of the great arteries. An analysis from the TOPP registry
Authors: Wacker Julie , Humpl Tilman , Berger Rolf M. F. , Ivy Dunbar , Bowers David , Bonnet Damien , Beghetti Maurice 
Published: February 2024

AimsA proportion of patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) do not fit in the current classification. We aimed to analyse the applicability of an adapted clinical classification of PAH-CHD to pediatric patients using the TOPP-1 registry (Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension) and focus on atrial septal defects (ASD) and transposition of the great arteries (TGA).Methods and resultsHemodynamic and clinical data of all patients with PAH-CHD in the TOPP cohort were reviewed. Patients were classified according to predefined ABCDE categories (A: Eisenmenger syndrome, B: left-to-right shunt, C: coincidental defects, including all ASDs, D: corrected CHD, E: TGA), or as complex CHD (group 5), by 2 independent investigators. In case of disagreement, a third reviewer could either settle a final decision, or the patient was deemed not classifiable. Survival curves were calculated for each group and compared to idiopathic PAH patients of the registry. A total of 223 out of 531 patients in the registry had PAH-CHD, and 193 were categorized to the following groups: A 39(20%), B 27(14%), C 62(32%) including 43 ASDs, D 58(30%), E 7(4%), whereas 6 patients were categorized as group 5, and 10 patients were unable to be classified. No survival difference could be demonstrated between the groups.ConclusionsThis modified classification seems to be more applicable to pediatric PAH-CHD patients than the previous classification, but some patients with PAH-CHD who never had a shunt remain unclassifiable. The role of ASD in pediatric PH should be reconsidered.
Proposed treatment strategy for reactive hypoglycaemia
Authors: Younes Younes R. , Cron Nicholas , Field Benjamin C.T. , Nayyar Vidhu , Clark James , Zachariah Sunil , Lakshmipathy Kavitha , Isuga Jimboy O. , Maghsoodi Negar , Emmanuel Julian 
Published: February 2024

Background/aimManaging reactive hypoglycaemia (RH) poses challenges due to limited and often ineffective treatment options. We report a case series and draw on this to propose a stepwise treatment approach consisting of lifestyle modifications, metformin, GLP-1 analogues, and the use of flash glucose monitoring technology.MethodA retrospective review was conducted to analyse the management of 11 cases presenting with recurrent RH symptoms.ResultTwo patients experienced successful resolution of symptoms through lifestyle modifications. Metformin alone was effective in treating seven out of nine patients who received pharmacological treatment. Two patients with previous upper gastrointestinal surgery showed a partial response to metformin and benefited further from additional long-acting GLP-1 analogue. Pharmacological intervention led to significant reductions in insulin and C-peptide levels in repeat mixed meal tolerance tests (P-values 0.043 for insulin and 0.006 for C-peptide). Finally, flash glucose monitoring technology was useful in early detection and preventing episodes of hypoglycaemia in one of these patients with persistent symptoms.ConclusionThese findings highlight the potential efficacy of escalated treatment strategies for RH, including the use of metformin, GLP-1 analogues, and flash glucose monitoring technology.
MIHIC: a multiplex IHC histopathological image classification dataset for lung cancer immune microenvironment quantification
Authors: Wang Ranran , Qiu Yusong , Wang Tong , Wang Mingkang , Jin Shan , Cong Fengyu , Zhang Yong , Xu Hongming 
Published: February 2024

BackgroundImmunohistochemistry (IHC) is a widely used laboratory technique for cancer diagnosis, which selectively binds specific antibodies to target proteins in tissue samples and then makes the bound proteins visible through chemical staining. Deep learning approaches have the potential to be employed in quantifying tumor immune micro-environment (TIME) in digitized IHC histological slides. However, it lacks of publicly available IHC datasets explicitly collected for the in-depth TIME analysis.MethodIn this paper, a notable Multiplex IHC Histopathological Image Classification (MIHIC) dataset is created based on manual annotations by pathologists, which is publicly available for exploring deep learning models to quantify variables associated with the TIME in lung cancer. The MIHIC dataset comprises of totally 309,698 multiplex IHC stained histological image patches, encompassing seven distinct tissue types: Alveoli, Immune cells, Necrosis, Stroma, Tumor, Other and Background. By using the MIHIC dataset, we conduct a series of experiments that utilize both convolutional neural networks (CNNs) and transformer models to benchmark IHC stained histological image classifications. We finally quantify lung cancer immune microenvironment variables by using the top-performing model on tissue microarray (TMA) cores, which are subsequently used to predict patients’ survival outcomes.ResultExperiments show that transformer models tend to provide slightly better performances than CNN models in histological image classifications, although both types of models provide the highest accuracy of 0.811 on the testing dataset in MIHIC. The automatically quantified TIME variables, which reflect proportions of immune cells over stroma and tumor over tissue core, show prognostic value for overall survival of lung cancer patients.ConclusionTo the best of our knowledge, MIHIC is the first publicly available lung cancer IHC histopathological dataset that includes images with 12 different IHC stains, meticulously annotated by multiple pathologists across 7 distinct categories. This dataset holds significant potential for researchers to explore novel techniques for quantifying the TIME and advancing our understanding of the interactions between the immune system and tumors.
Case report: From palliative to potentially curative – the advent of immunotherapy providing hope to advanced gallbladder adenocarcinoma
Authors: Leong Eugene Kwong Fei , Tan Nigel Chun Hian , Pang Ning Qi , Kow Alfred Wei Chieh 
Published: February 2024

IntroductionBiliary tract cancers (BTC) are often diagnosed at an advanced stage where prognosis is poor and curative-intent surgery is infeasible. First-line cisplatin-gemcitabine chemotherapy for advanced gallbladder cancer has remained unchanged over more than a decade, but recent developments in immunotherapy such as durvalumab have highlighted promise as a combination treatment regime with current standard chemotherapy.MethodsIn this case description, we present a case of locally-advanced gallbladder adenocarcinoma involving the biliary confluence that was initially planned for an extended right hepatectomy after portal vein embolization. Interval imaging revealed peritoneal metastasis, which was confirmed on diagnostic laparoscopy and biopsy. The patient underwent 8 cycles of cisplatin 25 mg/m2 and gemcitabine 1,000 mg/m2 chemotherapy on days 1 and 8 of each 21-day cycle, with durvalumab (Imfinzi®) 1,500 mg immunotherapy on day 1 of every cycle, in accordance with the treatment protocol of the TOPAZ-1 trial. Repeat imaging demonstrated a stable primary lesion with no further evidence of peritoneal disease. The patient subsequently underwent curative-intent conversion surgery with an extended right hepatectomy and Roux-en-Y hepaticojejunostomy, which were completed through a fully minimally-invasive laparoscopic approach.ResultsFinal pathological TNM classification was ypT1aN0, with near-complete pathological response to pre-surgical therapy, uninvolved margins (R0 resection) and tumour shrinkage from 2.5 centimetres on pre-operative cross-sectional imaging to 0.5 centimetres on final histology. The patient had an uneventful post-operative course, and was fit for discharge by the fourth post-operative day. He remained well after three months of routine post-operative follow-up, with no significant post-operative complications and biochemical or radiological evidence of disease recurrence.ConclusionOur case description highlights the immense potential of combination durvalumab immunotherapy with cisplatin-gemcitabine chemotherapy in the treatment of advanced gallbladder adenocarcinoma. The patient’s locally advanced disease was initially planned for complex open surgery, prior to discovery of peritoneal metastasis rendering it inoperable. This was successfully down-staged with combination therapy to eventual R0 resection via minimally-invasive surgery. In addition, this case description demonstrates the feasibility of a fully laparoscopic approach with postulated benefits of diagnostic re-evaluation of peritoneal disease, reduced wound pain and shorter length of hospital stay.
Exploring the origin and fate of surface and sub-surface marine microplastics in the Canary Islands region
Authors: Vega-Moreno Daura , Sicilia-González Sergio , Domínguez-Hernández Cristopher , Moreira-García Enedina , Aguiar-González Borja , Hernández-Borges Javier , Fraile-Nuez Eugenio , Machín Francisco 
Published: February 2024

The presence of different types of microplastics (MPs) in the Atlantic Ocean has been well-documented, with data collected from the Canary Islands indicating high concentrations of MPs at four different beaches (hot spots). However, critical gaps persist regarding the abundance of MPs in diverse open ocean regions, at varying depths, and their transport behavior and origin. This study aims to evaluate, for the first time, the large-scale (&gt;100 km) and mesoscale (10-100 km) ocean dynamic processes and the resulting transport of MPs in the region. On the one hand, this study investigates the surface velocity of currents between 27-32°N latitude range, establishing correlation with the accumulation of MPs on diverse beaches across several islands of the archipelago. This analysis goes beyond studying the predominant current by integrating data at a smaller geographical scale over a two-year period. Concurrently, previous and ongoing research suggests the presence of small MPs (SMPs,&lt;1 mm) at high concentration at a depth of 1100 meters in this region. By integrating these vertical profiles of MPs with a deep understanding of the physical processes of the Canary region accumulated over decades of research, our study introduces an innovative model that outlines how SMPs are sink and transported in open oceans by water mases. This comprehensive approach not only enhances our understanding of the complex dynamics influencing the distribution of MPs but also provides crucial insights to address the widespread problem of MP pollution in the Atlantic.
MLFLHMDA: predicting human microbe-disease association based on multi-view latent feature learning
Authors: Chen Ziwei , Zhang Liangzhe , Li Jingyi , Fu Mingyang 
Published: February 2024

IntroductionA growing body of research indicates that microorganisms play a crucial role in human health. Imbalances in microbial communities are closely linked to human diseases, and identifying potential relationships between microbes and diseases can help elucidate the pathogenesis of diseases. However, traditional methods based on biological or clinical experiments are costly, so the use of computational models to predict potential microbe-disease associations is of great importance.MethodsIn this paper, we present a novel computational model called MLFLHMDA, which is based on a Multi-View Latent Feature Learning approach to predict Human potential Microbe-Disease Associations. Specifically, we compute Gaussian interaction profile kernel similarity between diseases and microbes based on the known microbe-disease associations from the Human Microbe-Disease Association Database and perform a preprocessing step on the resulting microbe-disease association matrix, namely, weighting K nearest known neighbors (WKNKN) to reduce the sparsity of the microbe-disease association matrix. To obtain unobserved associations in the microbe and disease views, we extract different latent features based on the geometrical structure of microbes and diseases, and project multi-modal latent features into a common subspace. Next, we introduce graph regularization to preserve the local manifold structure of Gaussian interaction profile kernel similarity and add Lp,q-norms to the projection matrix to ensure the interpretability and sparsity of the model.ResultsThe AUC values for global leave-one-out cross-validation and 5-fold cross validation implemented by MLFLHMDA are 0.9165 and 0.8942+/−0.0041, respectively, which perform better than other existing methods. In addition, case studies of different diseases have demonstrated the superiority of the predictive power of MLFLHMDA. The source code of our model and the data are available on https://github.com/LiangzheZhang/MLFLHMDA_master.
The effects of transcranial magnetic stimulation for freezing of gait in Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
Authors: Liu Zicai , Wen Xin , Xie Xiuying , Liu Yangyou , Tan Cheng , Kuang Shuanghong , Liu Huiyu 
Published: February 2024

BackgroundFreezing of gait (FOG) is one of the most disabling gait disturbances in Parkinson’s disease (PD), affecting mobility and balance severely, thereby leading to an increased risk of falls.ObjectivesThe purpose of this systematic review and meta-analysis was to investigate the effects of transcranial magnetic stimulation on FOG in PD.MethodsBased on PRISMA guidelines, we searched the databases of MEDLINE (PubMed), Cochrane Library, PEDro, Embase, and Web of Science. Studies of the English language published up to July 2023 were searched. We retrieved for studies of randomized controlled trials (RCTs) of transcranial magnetic stimulation to treat FOG after PD and screened by inclusion and exclusion criteria. Risk of bias was assessed using the Cochrane Collaboration’s tool (Revman5.30). Characteristics of RCTs were extracted. The heterogeneity of the trials was measured by I2 statistic. The effect size was expressed by a standardized mean difference (SMD) with a 95% confidence interval (CI).ResultsA total of 488 articles were screened, after screening sixteen RCTs involved in 408 patients were included in the qualitative analysis, and 15 RCTs were included in meta-analysis. The outcome measures included FOG-Q, walking time, TUG, and UPDRS. Six studies used FOG-Q as outcome measure, six studies used walking time, four studies used TUG, and six studies used UPDRS. Compared with placebo treatment, transcranial magnetic stimulation has positive significant effects in improving gait status with increased walking speed (SMD = −0.41, 95% CI = −0.75 to −0.06, I2 = 7% p = 0.02), FOG-Q scores (SMD = −0.55, 95% CI = −0.89 to −0.21, I2 = 29%, p = 0.002), UPDRS scores (SMD = −1.08, 95% CI = −1.39 to −0.78, I2 = 49%, P &lt; 0.001) and the time of TUG (SMD = −0.56, 95% CI = −0.88 to −0.23, I2 = 25%, p = 0.02) decreased.ConclusionTranscranial magnetic stimulation could significantly improving gait conditions in PD patients with FOG.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails, CRD42023434286.