COMPARATIVE ASSESSMENT OF COMPLEX DRUGS BASED ON TOLTRAZURIL AND MOXIDECTIN AND TOLTRAZURIL AND EMODEPSIDE FOR NEMATODOSES AND CYSTOISOSPOROSIS OF DOGS
Authors: Tishyn O. L. , Yuskiv I. D. , Yuskiv L. L. 
Published: November 2023

The article presents data on the effectiveness of the new domestic complex antiparasitic drug "Profilin coccid" (suspension for oral use) in comparison with the reference drug "Prokoks@ for dogs" when used for the treatment and prevention of endoparasitic infestations in dogs of various breeds, age, sex and body weight.
According to the results of coprological studies, the animals of the experimental and control groups were found to have spontaneously infected dogs with endoparasites, the causative agents of digestive tract nematodes: Toxocara canis, with an intensity of invasion (II) of 100 to 190 eggs in one gram of feces (ЕGF) with an average intensity of invasion of 140.9 ± 4.07 ЕGF and Ancylostoma caninum with an intensity of invasion of 36 to 54 eggs in 1 g of feces with an average intensity of invasion of 44.9 ± 1.45 ЕGF, as well as coccidia of the alimentary canal of the species Cystoisospora canis with an intensity of invasion of 580 to 750 oocysts in 1 g of feces (OGF) with an average intensity of invasion of 677.5 ± 4.07 OGF. Clinically, nematodes of the alimentary canal in dogs and puppies were manifested by: loss of appetite, depression, pallor of the mucous membranes, and in some animals vomiting and mild diarrhea, and in cystoisosporosis - depression, motility, weight loss, during defecation - feces are liquid, sometimes with impurities of mucus.
After the use of the drugs "Profilain coccid" and "Prokoks@ for dogs", coprological studies were carried out with the establishment of indices of parasitological damage and determination of the intensive effectiveness (IE) and extensive effectiveness (EE) of the drugs.
On the basis of the obtained results, it was established that for a spontaneous toxocarosis infestation of dogs on the 7th day after deworming, the intensity of the drug "Profilin coccid" was 96.2 %, and the reference drug "Prokoks@ for dogs" was 96.9 %. On the 14th day after deworming the animals, the intensive and extensive effectiveness of both drugs was 100%.
Helminthological studies established that for spontaneous hookworm infestation in dogs 7 and 14 days after the use of the researched drug and the reference drug in the recommended doses, the intensive and extensive effectiveness of veterinary drugs was 100 %.
In case of spontaneous cystoisosporosis infestation in dogs, it was established that on 3 and 7 days after oral administration of the drugs to the animals, the intensity of the studied drug was 53.0 and 85.2 %, and the intensity of the reference drug was 56.0 and 87.3 %, respectively. On the 14th, 21st, 28th, and 35th day after the use of drugs in the form of a suspension, the intensive and extensive effectiveness for cystoisosporosis in dogs was 100 %.
Field tests showed that the investigational drugs "Profilin coccid" and "Prokoks@ for dogs" are convenient to use and well tolerated by dogs and puppies, regardless of breed, age, sex and body weight, when they are used once orally in the medicinal form of a suspension in the dosage recommended by the manufacturer , and do not have a toxic effect on the body of animals.