bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMP2ART: development of a multi-level programme theory integrating the COM-B model and the iPARIHS framework, to enhance implementation of supported self-management of asthma in primary care
Authors: Steed Liz , Sheringham Jessica , McClatchey Kirstie , Hammersley Vicky , Marsh Viv , Morgan Noelle , Jackson Tracy , Holmes Steve , Taylor Stephanie , Pinnock Hilary 
Published: November 2023

Abstract
Background
Supported asthma self-management, incorporating an asthma action plan and annual clinical review, has been recommended by UK/global guidelines for over three decades. However, implementation remains poor, as only around a third of individuals receive basic asthma care, according to the UKs leading respiratory charity Asthma and Lung UK. A systematic review of implementation studies recommended that a whole systems approach targeting patients, healthcare professional education, and organisations is needed to improve implementation of supported asthma self-management in primary care. The IMPlementing IMProved Asthma self-management as RouTine (IMP2ART) is a national Hybrid-II implementation cluster randomised controlled trial that aims to evaluate such an approach. This paper describes the development of the implementation strategy for IMP2ART with particular focus on the integration of multiple level theories.

Methods
The Medical Research Council design and evaluation of complex interventions framework and the Person-Based Approach to intervention development were used as guidance for stages of strategy development. Specifically, we (i) set up a multidisciplinary team (including practicing and academic clinicians, health psychologists, public health and patient colleagues), (ii) reviewed and integrated evidence and theory, (iii) developed guiding principles, (iv) developed prototype materials, and (v) conducted a pre-pilot study before final refinement.

Results
The implementation strategy included resources for patients, team-based and individual healthcare professional education, practice audit and feedback, and an asthma review template, as well as a facilitator role accessible to primary care practices for 12 months. The synthesis of the integrated Promoting Action on Research Implementation in Health Services (iPARIHS) and Capability, Opportunity, Motivation and Behaviour (COM-B) frameworks led to an evolved framework bringing together important implementation and behaviour change elements which will be used as a basis for the study process evaluation.

Conclusions
A description of rigorous implementation strategy development for the IMP2ART study is provided along with newly theorised integration of implementation and behaviour change science which may be of benefit to others targeting implementation in primary care.

Trial registration
ISRCTN15448074. Registered on 2nd December 2019.
The effect of electricity consumption determinants in household load forecasting models
Authors: Bakiri Hussein A. , Mbembati Hadija 
Published: November 2023

AbstractUsually, household electricity consumption fluctuates, often driven by several electrical consumption determinants such as income, household size, and price. Recently, research studies on the investigation of predictor variables in household electricity consumption have increased especially in the developing and newly industrialized countries. However, the studies just focus on identifying the predictor variables of household electricity consumption that influence load forecasting models. In Tanzania, for instance, scholars found that using the “income” determinant improves the performance of a forecasting model. The scholars suggest without any empirical bases that adding more predictor variables would have improved the accuracy of the model. This study aims to analyze the effect of the number of predictor variables on household load forecasting performance based on Tanzania’s data. Nonlinear regression based on a Weibull function and multivariate adaptive regression splines approaches are used for this purpose. Our findings indicate that income, household size, and number of appliances are common predictor variables of household consumption in developing countries. The measured forecasting root-mean-square error (RMSE) when using income, household size, and the number of appliances is 0.8244, 1.2314, and 0.9868, respectively. Finally, we forecasted load using all three determinants and the RMSE dropped to 0.7031. Having obtained the smaller value of RMSE when all predictors are used reveals that the inclusion of all three predictor variables in load forecasting leads to a significant decrease in RMSE by 14.73%. Therefore, the study recommends using multiple predictor variables in load forecasting models to increase accuracy.
Demography and fitness of Sesamia inferens Walker (Lepidoptera: Noctuidae) on three important gramineous crops
Authors: Li Chen , Shen Zhen , Tang Liang-De , Wang Xi-Ya , Huang Yuan-Qin , Zhang Yu-Fei , Mu Ming-Yue , Smagghe Guy , Zang Lian-Sheng 
Published: November 2023

Abstract
Background
Pink stem borer, Sesamia inferens (Walker), a major rice pest, has rarely been reported to cause serious damage to sorghum in China. During a survey of insect pests in glutinous sorghum for Chinese liquor production areas in Guizhou Province, it was found that S. inferens has caused serious damage to local sorghum in recent years.

Methods
In this context, we assessed the adaptation of S. inferens to three gramineous crop host plants (maize, rice and sorghum) based on age-stage, two-sex life table theory.

Results
Sesamia inferens had the highest development time, survival rate and total longevity on rice, followed by on sorghum and maize. There was no significant difference in intrinsic rate of increase and finite rate of increase among maize (r = 0.0702 day−1, λ = 1.0727 day−1), sorghum (r = 0.0681 day−1, λ = 1.0705 day−1) and rice (r = 0.0645 day−1, λ = 1.0666 day−1), but the mean generation period (T) was significantly higher for populations reared on rice (53.84 days) than on sorghum (49.53 days) and maize (47.31 days).

Conclusions
The results of our study indicate that S. inferens was able to complete the full developmental cycle on all three host plants. This study further supports that glutinous sorghum is an adaptable host plant for S. inferens.
Influence of pulse-tail energy of short-pulse CO2 laser in drilling of various glasses
Authors: Uno Kazuyuki , Kodama Yasushi , Yoneya Kazuyuki 
Published: November 2023

AbstractIn a short-pulse CO2 laser based on discharge excitation, there is a pulse tail that depends on the device configuration and operating conditions. The pulse tail is longer than the spike pulse and causes thermal effects such as a crack, heat-affected zones (HAZ), and so on. There are various types of glass having different physical constants related to heat, such as the thermal expansion coefficient and the softening point. Even if the same CO2 laser pulse is radiated onto glass, the processing results may differ depending on the glass material. Four types of glass, namely, crown glass, soda-lime glass, borosilicate glass, and synthetic quartz glass were irradiated with two types of short CO2 laser pulses, one with a large pulse tail and one with a small pulse tail, at a repetition rate of 200 Hz and a fluence per pulse of 22 J/cm2. As the processing characteristics, the ratios of the surface hole diameter and the HAZ diameter to the irradiation diameter, as well as the drilling depth, were investigated. The pulse-tail energy of the short CO2 laser pulses did not affect the surface hole diameter. In the glasses with small softening points of 740 °C or less, the pulse-tail energy of short CO2 laser pulses affected the HAZ with a large number of pulse irradiations with a total irradiation fluence of 2000 J/cm2 or more. The short CO2 laser pulses with a small tail produced a smaller HAZ than the short CO2 laser pulses with a large tail. In drilling with a large number of pulse irradiations, the short CO2 laser pulses with a small tail produced deeper drilling than the short CO2 laser pulses with a large tail. The glass material did not affect the surface hole diameter and the drilling depth. The glass material affected the HAZ.
Vitamin D Status During Adolescence and the Impact of Lifestyle Changes: 2 Years’ Follow-up From the Fit Futures Study
Authors: Öberg Johanna , Jorde Rolf , Almås Bjørg , Nielsen Christopher Sivert , Gerds Thomas Alexander , Cashman Kevin D , Grimnes Guri 
Published: November 2023

AbstractContextLongitudinal data regarding vitamin D status in adolescence is scarce. This study presents population-based data from an Arctic adolescent population (n = 589) at 16 and 18 years.ObjectiveThe aims of this study were to investigate changes in vitamin D status during 2 years in adolescence, and whether lifestyle changes were associated with serum 25-hydroxyvitamin D (s-25(OH)D) at follow-up.MethodsFit Futures is a longitudinal study at 69°N in Norway. Participants had their s-25(OH)D levels analyzed in their first and third year of upper secondary school (median age 16 and 18 years), in Fit Futures 1 (FF1) and Fit Futures 2 (FF2), respectively. Self-reported lifestyle habits were registered through questionnaires. The association between lifestyle changes and s-25(OH)D levels at follow-up were calculated by regression analyses, controlling for baseline s-25(OH)D levels.ResultsLongitudinal data were available for 309 girls and 280 boys. The proportion of adolescents with s-25(OH)D &lt;50 nmol/L were 73.7% in FF1 and 77.1% in FF2, while the proportion &lt;30 nmol/L constituted 35.7% in FF1 and 40.9% in FF2. Of those with s-25(OH)D &lt;30 nmol/L (severe vitamin D deficiency) in FF1, 73.3% remained severely deficient in FF2. Among boys, an increase in UV exposure was significantly associated with higher s-25(OH)D levels in FF2 (beta; CI [nmol/L] 12.9; 9.1, 16.7). In girls, decreased vitamin/mineral supplement intake was significantly associated with lower s-25(OH)D at FF2 (−6.7; −10.2, −3.1), while increased UV (10.8; 7.0, 14.7) and combined hormonal contraceptive exposure (12.1; 6.0, 18.1) in FF2 was significantly associated with higher s-25(OH)D levels in FF2.ConclusionSevere vitamin D deficiency was prevalent throughout adolescence. Lifestyle changes may alter s-25(OH)D levels in this age group.
Signs of Glucagon Resistance After a 2-Week Hypercaloric Diet Intervention
Authors: Suppli Malte Palm , Høgedal Astrid , Bagger Jonatan Ising , Chabanova Elizaveta , van Hall Gerrit , Forman Julie Lyng , Christensen Mikkel Bring , Albrechtsen Nicolai Jacob Wewer , Holst Jens Juul , Knop Filip Krag 
Published: November 2023

AbstractContextHyperglucagonemia is observed in individuals with obesity and contributes to the hyperglycemia of patients with type 2 diabetes. Hyperglucagonemia may develop due to steatosis-induced hepatic glucagon resistance resulting in impaired hepatic amino acid turnover and ensuing elevations of circulating glucagonotropic amino acids.ObjectiveWe evaluated whether glucagon resistance could be induced in healthy individuals by a hypercaloric diet intervention designed to increase hepatic fat content.MethodsWe recruited 20 healthy male individuals to follow a hypercaloric diet and a sedentary lifestyle for 2 weeks. Amino acid concentrations in response to infusion of glucagon were assessed during a pancreatic clamp with somatostatin and basal insulin. The reversibility of any metabolic changes was assessed 8 weeks after the intervention. Hepatic steatosis was assessed by magnetic resonance spectroscopy.ResultsThe intervention led to increased hepatic fat content (382% [206%; 705%], P &lt; .01). Glucagon infusion led to a decrease in the concentration of total amino acids on all experimental days, but the percentage change in total amino acids was reduced (−2.5% ± 0.5% vs −0.2% ± 0.7%, P = .015) and the average slope of the decline in the total amino acid concentration was less steep (−2.0 ± 1.2 vs −1.2 ± 0.3 μM/min, P = .016) after the intervention compared to baseline. The changes were normalized at follow-up.ConclusionOur results indicate that short-term unhealthy behavior, which increases hepatic fat content, causes a reversible resistance to the effect of glucagon on amino acid concentrations in healthy individuals, which may explain the hyperglucagonemia associated with obesity and diabetes.
Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing
Authors: Fulcher James M , Swensen Adam C , Chen Yi-Chun , Verchere C Bruce , Petyuk Vladislav A , Qian Wei-Jun 
Published: November 2023

Abstract
Altered prohormone processing, such as with proinsulin and pro-islet amyloid polypeptide (proIAPP), has been reported as an important feature of prediabetes and diabetes. Proinsulin processing includes removal of several C-terminal basic amino acids and is performed principally by the exopeptidase carboxypeptidase E (CPE), and mutations in CPE or other prohormone convertase enzymes (PC1/3 and PC2) result in hyperproinsulinemia. A comprehensive characterization of the forms and quantities of improperly processed insulin and other hormone products following Cpe deletion in pancreatic islets has yet to be attempted. In the present study we applied top-down proteomics to globally evaluate the numerous proteoforms of hormone processing intermediates in a β-cell-specific Cpe knockout mouse model. Increases in dibasic residue–containing proinsulin and other novel proteoforms of improperly processed proinsulin were found, and we could classify several processed proteoforms as novel substrates of CPE. Interestingly, some other known substrates of CPE remained unaffected despite its deletion, implying that paralogous processing enzymes such as carboxypeptidase D (CPD) can compensate for CPE loss and maintain near normal levels of hormone processing. In summary, our quantitative results from top-down proteomics of islets provide unique insights into the complexity of hormone processing products and the regulatory mechanisms.
“A Land of Dreams and Nightmares”: Race, Afro-Asia, and Decolonization in Mauritius
Authors: Rouphail Robert M. 
Published: November 2023

AbstractThe Cold War Indian Ocean world was a space in transition. As European empires retreated from the ocean's littoral states, the structure and makeup of what political entities would follow remained opaque and contested. Mauritius's relatively late formal decolonization in 1968 was a case in point: as “winds of change” blew across Indian Ocean Africa, the impending departure of the British from the island threw into stark relief how different racial groups understood their collective diasporic pasts and weighed potential futures free from British rule. This essay examines how race shaped popular conversations on Mauritian political independence through two areas of analysis. The first is a discussion of Mauricianisme, a mid-century project of building a multiracial Mauritian political identity that could accommodate and integrate its African and Asian components to chart a path forward in the postcolonial world. Second is an analysis of a singular Afro-Mauritian newspaper published in the 1950s and 1960s, L’Épée, and how it approached questions of race and decolonization. Taken together, the following pages offer a view into how nationwide debates attempted to reconcile deep histories that spanned the Indian Ocean and to smooth the jagged historical rifts between communal groups with an eye toward political independence.
Parameterizing mechanistic niche models in biophysical ecology: a review of empirical approaches
Authors: Riddell Eric A. , Burger Isabella J. , Tyner-Swanson Tamara L. , Biggerstaff Justin , Muñoz Martha M. , Levy Ofir , Porter Cody K. 
Published: November 2023

ABSTRACT
Mechanistic niche models are computational tools developed using biophysical principles to address grand challenges in ecology and evolution, such as the mechanisms that shape the fundamental niche and the adaptive significance of traits. Here, we review the empirical basis of mechanistic niche models in biophysical ecology, which are used to answer a broad array of questions in ecology, evolution and global change biology. We describe the experiments and observations that are frequently used to parameterize these models and how these empirical data are then incorporated into mechanistic niche models to predict performance, growth, survival and reproduction. We focus on the physiological, behavioral and morphological traits that are frequently measured and then integrated into these models. We also review the empirical approaches used to incorporate evolutionary processes, phenotypic plasticity and biotic interactions. We discuss the importance of validation experiments and observations in verifying underlying assumptions and complex processes. Despite the reliance of mechanistic niche models on biophysical theory, empirical data have and will continue to play an essential role in their development and implementation.
What makes a great invader? Anatomical traits as predictors of locomotor performance and metabolic rate in an invasive frog
Authors: Padilla Pablo , Herrel Anthony , Denoël Mathieu 
Published: November 2023

ABSTRACT
Invasive species are characterized by their ability to establish and spread in a new environment. In alien populations of anurans, dispersal and fitness-related traits such as endurance, burst performance and metabolism are key to their success. However, few studies have investigated inter-individual variation in these traits and more specifically have attempted to understand the drivers of variation in these traits. Associations of anatomical features may be excellent predictors of variation in performance and could be targets for selection or subject to trade-offs during invasions. In this study, we used marsh frogs (Pelophylax ridibundus), a species that has been introduced in many places outside its native range and which is now colonizing large areas of Western Europe. We first measured the inter-individual variation in resting metabolism, the time and distance they were able to jump until exhaustion, and their peak jump force, and then measured the mass of specific organs and lengths of body parts suspected to play a role in locomotion and metabolism. Among the 5000 bootstrap replicates on body size-corrected variables, our statistical models most often selected the stomach (75.42%), gonads (71.46%) and the kidneys (67.26%) as predictors of inter-individual variation in metabolism, and the gluteus maximus muscle (97.24%) mass was the most frequently selected predictor of jump force. However, endurance was poorly associated with the anatomical traits (R2distance=0.42, R2time=0.37). These findings suggest that selection on these predictors may lead to physiological changes that may affect the colonization, establishment and dispersal of these frogs.
A snapshot of 100 years of discovery
Authors: Knight Kathryn 
Published: November 2023

ABSTRACT
With a century of literature behind Journal of Experimental Biology (JEB) in 2023, I look at some of the extraordinary papers contained within its archive. From publishing Nobel Prize-inspiring discoveries to founding fields and solving long-standing mysteries, the journal has been at the hub of experimental biology for 10 decades, leading the way and shining a light on the physiology of many remarkable animal species. In this Perspective, I highlight some of the key players in the field, summarise their seminal works and consider their long-term impact as JEB embarks on its next 100 years.
Effect of glycerin as a plasticizer on flexural strength in the fabrication of gypsum-based chip
Authors: Madarina Amira , Irawan Bambang , Sunarso Sunarso 
Published: November 2023

Background: Ceramic-based drug delivery systems has received significant attention in both medical and material domains. This study used gypsum as a base material for drug delivery chips, which has the potential to replace existing materials such as collagen and gelatin. The choice of gypsum as a material was based on a unique combination of osteoconductive, bioresorbable, and biodegradable characteristics. Methods: In this study, glycerin was added to distilled water at different concentrations (5%, 10%, 15%, 20%, and 25%) to increase the flexibility of gypsum. Calcium Sulfate Hemihydrate powder was then combined with a mixed solution of water and glycerin and stirred. The mixture was then placed in an acrylic mold measuring 25 x 3 x 1.5 mm and allowed to dry for 24 hours at room temperature. After that, the specimen was analyzed to determine flexural strength using the Universal Testing Machine with a three-point bending method at a crosshead speed of 0.5 mm/min. Results: Statistical analysis revealed that the inclusion of glycerin led to an increase in the percentage of strain. However, it has been observed that the mechanical strength of gypsum chips shows a proportional decrease with increasing glycerin concentration. Conclusions: It can be concluded that the addition of glycerin into the gypsum chip can increase the elasticity of the chip even though the flexural strength is reduced.
Case Report: Fever of unknown origin caused by type Ⅱ lepra reaction
Authors: Ran Xiaojuan , Ma Ke , Wang Yanxia , Wu Yayun 
Published: November 2023

We report an ethnic minority patient presenting as fever of unknown origin for over 25 days, who was admitted with atypical cutaneous lesions, damages in the peripheral joints and nervous system. Owing to tracing the past medical history, the patient has received a prompt diagnosis and achieved good outcome. By summarizing the entire diagnosis and treatment process, we report the case to deepen the understanding of fever of unknown origin caused by type Ⅱ lepra reaction. All specialties, meanwhile, should be aware of the rare infectious diseases in daily medical practice.
Highly sensitive temperature and refractive index sensor based on no-core fiber cascaded with a balloon-shaped bent single-mode fiber
Authors: Zhu Xiaojun , Song Mengqiang , Liu Xing , Liu Wen , Pan Yongquan , Cao Juan , Zhang Guoan , Yang Yongjie , Shi Yuechun , Wu Wuming 
Published: November 2023

A highly sensitive temperature and refractive index (RI) sensor based on no-core fiber (NCF) cascaded with a balloon-shaped bent single-mode fiber (BSBSF) is proposed and demonstrated. The NCF can excite higher-order modes which will be concentrated and transmitted into the BSBSF due to the characteristic of self-imaging effect. The BSBSF has an excellent temperature performance due to the high thermo-optical coefficient and thermal expansion coefficient of the polymer coating. The NCF and BSBSF are both conducive to the excitation of higher-order modes, which induces the sensitivity of the sensor with an efficiency improvement. The experimental results show that the maximum temperature sensitivity is −3.19nm/∘C in the range of 22°C–83°C, which is the highest temperature sensitivity in the cascaded BSBSF structure to our best knowledge. In addition, the maximum RI sensitivity is 232.16 nm/RIU when the RI changes from 1.3234 to 1.3512. Compared with other cascaded BSBSF structures, this sensor has a higher temperature sensitivity and can be applicated in the prospects of food, biology, and environmental monitoring.