bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is synthetic data generation effective in maintaining clinical biomarkers? Investigating diffusion models across diverse imaging modalities
Authors: Hosseini Abdullah , Serag Ahmed 
Published: January 2025

IntroductionThe integration of recent technologies in medical imaging has become a cornerstone of modern healthcare, facilitating detailed analysis of internal anatomy and pathology. Traditional methods, however, often grapple with data-sharing restrictions due to privacy concerns. Emerging techniques in artificial intelligence offer innovative solutions to overcome these constraints, with synthetic data generation enabling the creation of realistic medical imaging datasets, but the preservation of critical hidden medical biomarkers is an open question.MethodsThis study employs state-of-the-art Denoising Diffusion Probabilistic Models integrated with a Swin-transformer-based network to generate synthetic medical data. Three distinct areas of medical imaging - radiology, ophthalmology, and histopathology - are explored. The quality of synthetic images is evaluated through a classifier trained to identify the preservation of medical biomarkers.ResultsThe diffusion model effectively preserves key medical features, such as lung markings and retinal abnormalities, producing synthetic images closely resembling real data. Classifier performance demonstrates the reliability of synthetic data for downstream tasks, with F1 and AUC reaching 0.8–0.99.DiscussionThis work provides valuable insights into the potential of diffusion-based models for generating realistic, biomarker-preserving synthetic images across various medical imaging modalities. These findings highlight the potential of synthetic data to address challenges such as data scarcity and privacy concerns in clinical practice, research, and education.
Artificial intelligence applied to diabetes complications: a bibliometric analysis
Authors: Tao Yukun , Hou Jinzheng , Zhou Guangxin , Zhang Da 
Published: January 2025

Background and aimsArtificial intelligence (AI)-driven medical assistive technology has been widely used in the diagnosis, treatment and prognosis of diabetes complications. Here we conduct a bibliometric analysis of scientific articles in the field of AI in diabetes complications to explore current research trends and cutting-edge hotspots.MethodologyOn April 20, 2024, we collected and screened relevant articles published from 1988 to 2024 from PubMed. Based on bibliometric tools such as CiteSpace, Vosviewer and bibliometix, we construct knowledge maps to visualize literature information, including annual scientific production, authors, countries, institutions, journals, keywords and research hotspots.ResultsA total of 935 articles meeting the criteria were collected and analyzed. The number of annual publications showed an upward trend. Raman, Rajiv published the most articles, and Webster, Dale R had the highest collaboration frequency. The United States, China, and India were the most productive countries. Scientific Reports was the journal with the most publications. The three most frequent diabetes complications were diabetic retinopathy, diabetic nephropathy, and diabetic foot. Machine learning, diabetic retinopathy, screening, deep learning, and diabetic foot are still being researched in 2024.ConclusionGlobal AI research on diabetes complications is expected to increase further. The investigation of AI in diabetic retinopathy and diabetic foot will be the focus of research in the future.
Influence of working conditions on German paramedics' intention to leave the profession: a cross-sectional study
Authors: Hofmann Thomas , Stanley Michael , Möckel Luis 
Published: January 2025

IntroductionIt is well known that Germany's ambulance service (AS) suffers from a shortage of qualified personnel, which may increase in the following years. For this reason, this study aimed to determine the percentage of AS staff considering leaving their profession and to analyse the possible causes.MethodsA self-developed questionnaire and the Employee Experience Questionnaire (EXQ) were used for this cross-sectional study.ResultsA total of 814 AS staff with a mean age of 35.71 [standard deviation (SD) 9.78] years were included in this study. Immediately leaving the AS was the intention of 17.27% of participants, with 2.86% having already resigned, 14.29% taking actions such as applying for a job, and another 14.04% specifically planning to leave the AS in the foreseeable future. Those who plan to leave the AS immediately [3.82 (SD 0.79)] showed significantly lower EXQ scores than the group who plan to stay in the EMS until retirement [4.92 (SD 0.87); pTukey ≤0.001]. At the same time, it is noticeable that EMS staff often suffer from unfavourable working conditions, such as not being granted breaks, work-related calls during free time, and over time, and significant correlations with the planned length of stay in the paramedic service and exit thoughts were identified here.ConclusionUnfavourable working conditions further aggravate the already existing shortage of qualified personnel in the ambulance service, so measures by various decision-makers are imperative.
AI-powered estimation of tree covered area and number of trees over the Mediterranean island of Cyprus
Authors: Zenonos Anna , Li Sizhuo , Brandt Martin , Sciare Jean , Ciais Philippe 
Published: January 2025

Trees play a crucial role in mitigating climate change by absorbing CO2 and providing biophysical cooling. The European Commission’s climate policies underscore the importance of forest monitoring systems to achieve substantial greenhouse gas reductions by 2030. In Cyprus, an EU member state located in the Eastern Mediterranean, and a climate change hot-spot, increasingly impacted by forest fires and more arid conditions, the absence of a comprehensive tree monitoring system hinders effective carbon stock assessment and land-based mitigation strategies. The exact tree population inside and outside forests is currently unknown. Artificial Intelligence is a powerful tool that can enable the development of tree monitoring systems by applying machine learning models to high-resolution image data. This study presents a deep learning neural network model applied to high resolution (10 cm) airborne images collected during the year 2019, to generate segmented tree crowns and the number of individual trees over selected areas of Cyprus, including a large national forest park, a forest park in the capital city, and a small urban area, encompassing a total studied area of 107km2. The model, previously applied in Denmark and Finland was completely re-tuned using local annotations to account for Cyprus’s specific conditions and achieved an overall accuracy of 90% and 93% to estimate the area covered by tree crowns and the number of trees, respectively. The results are regressed against coarser resolution tree cover maps to predict the area covered by tree crowns at a national level. The accuracy of the tree cover maps created by this study is compared to those of existing global tree cover maps, such as the Copernicus products. This work lays the foundation for establishing a tree-level inventory for Cyprus using airborne remote-sensing.
Factores asociados al éxito en el otorgamiento de las patentes y el impacto comercial en universidades reconocidas como innovadoras a nivel global
Authors: Quiroga-Arcieniegas Vanessa-Mercedes 
Published: January 2025

Uno de los aspectos relevantes al trabajar datos de innovación son sus múltiples definiciones, sin embargo, la OCDE en el Manual de Oslo estableció que una innovación sí y sólo sí era una innovación cuando esta pasaba por una validación de mercado. El propósito de este trabajo fue encontrar los determinantes que expliquen la innovación de algunas de las principales universidades del mundo, medida a través del licenciamiento de las patentes. Se realizó un modelo de regresión lineal múltiple que tuvo en cuenta las variables internas que afectan a las universidades. Se aplicó un muestreo no probabilístico por conveniencia utilizando como variables dependientes: el indicador de impacto comercial de las patentes y la tasa de éxito de las patentes publicados por el ranking de Reuters. En cuanto a las variables independientes, se utilizaron algunos de los indicadores del ranking Times Higher Education (THE). Los resultados de los modelos econométricos encontraron que los ingresos provenientes de la industria y el nivel de la investigación de las universidades afectan de manera significativa el éxito en el otorgamiento de las patentes y su impacto comercial en las universidades estudiadas. Concluyendo que, si las universidades quieren contribuir cada vez más a la innovación en los países donde operan desde la perspectiva de las patentes, es necesario que estrechen lazos de cooperación con la industria o sector productivo con el propósito de satisfacer cada vez más necesidades de la sociedad basada en conocimiento y desarrollo tecnológico.
Le détail pathopoétique : le cas de Coleridge
Authors: Bertonèche Caroline 
Published: January 2025

Cet article réfléchit à la manière dont certains détails du discours médical au dix‑neuvième siècle ont façonné la poésie romantique anglaise, en s’intéressant notamment au cas de Samuel Taylor Coleridge et à son rapport à deux maladies en particulier, la scrofule et l’épilepsie. Le détail pathopoétique tel qu’il est défini par l’étymologie du terme « pathopoèse » fait référence à la production des maladies, ce qu’elles génèrent dans l’univers mental et physique du poète mais également ce qu’elles apportent en termes de productivité et de créativité chez les romantiques dont l’expérience personnelle de la pathologie oscille entre affliction chronique et hypocondrie. Il suffit parfois d’un mot, d’une formule — savante, médicale —, d’un reliquat de phrase, d’un concept nouveau (ex. : le brownisme), d’un vestige du langage, ou d’une vision, même partielle, du mal pour stimuler l’imaginaire du poète. Sous l’influence de figures scientifiques importantes à l’époque comme le Dr Thomas Beddoes ou Erasmus Darwin, Coleridge est attentif à chacun de ces symptômes, fussent‑ils microscopiques, voire indétectables, pour donner à sa poésie un nouvel élan, en explorant notamment, dans l’intimité de la relation qu’il entretenait avec la médecine et les médecins, un périmètre d’inspiration plus large.
Impacts of capacitive current on electrolyte-gated graphene field-effect transistor arrays
Authors: Ushiba Shota , Nakano Tomomi , Tokuda Yuka , Tani Shinsuke , Kimura Masahiko , Matsumoto Kazuhiko 
Published: January 2025

Abstract
We investigate the effect of gate-source current (I
GS) on variations in the Dirac point voltage (V
DP) in electrolyte-gated graphene field-effect transistor (EG-GFET) arrays through a time-resolved analysis of I
GS and an equivalent circuit model. Source/drain electrodes exposed to the electrolyte induce a substantial capacitive current and a prolonged charging duration of the electric double-layer capacitance, which leads to a position-dependent V
DP variation relative to the gate electrode. The electrode-passivation alleviates the variation by significantly reducing I
GS and associated charging time. These findings offer critical insights for the design of integrated EG-GFET arrays.
A Democracia militante na pauta do Supremo Tribunal Federal
Authors: Martins Gilberto Marcos , Sampaio José Adércio Leite 
Published: January 2025

O apogeu democrático vivido dos anos 1990 sofreu uma grave inflexão a partir do início do século XXI. Ao lado das tradicionais rupturas institucionais, governos, quase sempre, populistas, começaram a erodir o edifício democrático a partir de dentro. Com reformas constitucionais e alterações legislativas que escapam ao controle de constitucionalidade, mediadas por apelos a uma suposta vontade soberana do povo e discursos antissistemas, introduziram elementos iliberais na argamassa democrática. Práticas iliberais passaram a conviver com práticas de democracia militante revelando “sinkholes” nos sistemas democráticos, evidenciando que o modelo de democracia do século passado não mais se sustenta. As democracias estão vivendo um processo de regressão ou corrosão em praticamente todos os cantos do mundo, principalmente, por meio do surgimento de líderes populistas e iliberais. O Brasil não é exceção. O proposito deste simpósio é discutir de que forma as práticas iliberais tem se manifestado e que tipo de medidas têm sido adotadas para contê-las. Especialmente no âmbito das Cortes Constitucionais. No caso do Brasil, entre outras práticas, destaca-se o protagonismo que assumiu o Supremo Tribunal Federal no esforço de, no próprio curso da erosão democrática, tentar conter sua evolução. Um protagonismo inusual, com uma atuação preventiva e reativa ao mesmo tempo. As consequências dessa atuação são pontos que se abrem ao futuro. O ponto central do debate volta-se para os mecanismos que podem ser criados para que as democracias possam evitar a erosão dos seus próprios alicerces, e, se os que já estão sendo colocados em prática alcançam ou não seus objetivos.
PENERAPAN MANAJEMEN PERUBAHAN DALAM PENCAPAIAN TARGET HASIL PEMBELAJARAN DI SEKOLAH ISLAM NABILAH
Authors: Sarmini  , Windayati Diana Titik , Mustika Ita 
Published: January 2025

ABSTRAK
Dalam dunia Pendidikan perubahan sangat penting, karena Pendidikan harus terus berkembang menjadi lebih baik sesuai dengan tuntutan dan tantangan jaman. Sekolah atau satuan Pendidikan wajib menerapkan manajemen perubahan sehingga tercapai keefektifan dan keefisiensian. Begitupun dengan target belajar Pengabdian ini menggunakan metode kualitatif. Peneliti mendeskripsikan temuan-temuan dari fenomena yang terjadi di lapangan. Bahwasannya sebuah perubahan merupakan sesuatu yang mutlak terjadi di semua aspek, termasuk juga aspek Pendidikan. Dalam hal ini Tim PKM mengadakan pengabdian Masyarakat di Lokasi Sekolah Islam Nabilah, Dutamas, Batam bertujuan untuk mengenalkan Manajemen Perubahan dalam Pencapaian Target Hasil pembelajaran di Sekolah Islam Nabilah. Sasaran dari pengabdian ini adalah guru dan siswa SMP dan SMA Islam Nabilah, karena perubahan harus bersama-sama dilakukan oleh warga sekolah. Pelaksana PKM adalah 4 dosen Universitas Batam dan Universitas Ibnu Sina Batam, serta 4 mahasiswa prodi Manajemen. Pelaksanaan PKM dengan cara mengadakan Sosialisasi terhadap siswa dan guru, yang dilaksanakan pada tanggal 17 Januari 2025.
Kata Kunci: Manajemen Perubahan, Pencapaian, Target Pembelajaran
ABSTRACT
Change management according to Lewin consists of the process of Unfreezing (recognizing the need for change), Changing (trying to create new conditions, Refreshing (combining, creating and maintaining change). This study uses a qualitative method. The researcher describes the findings of the phenomena that occur in the field. That a change is something that absolutely happens in all aspects, including the aspect of Education. In this case, the PKM Team held Community Service at the Nabilah Islamic School Location, Dutamas, Batam with the aim of introducing Change Management in Achieving Learning Outcome Targets at the Nabilah Islamic School. The target of this service is teachers and students of Nabilah Islamic Middle and High Schools, because changes must be carried out together by the school community. The PKM implementers are 4 lecturers from Batam University and 4 students of the Management study program. The implementation of PKM is by holding Socialization for students and teachers, which was carried out on January 17, 2025
Keywords: Change Management, Achievement, Learning Targets
FORMULASI DAN EVALUASI MASKER GEL PEEL OFF EKSTRAK ETANOL 96% DAUN BINJAI (Mangifera caesia Jack. Ex. Wall)
Authors: Nurhasna Fitria , Jamaludin Wahyudin Bin , Afra Fairuz Yaumil 
Published: January 2025

Ekstrak etanol 96% daun binjai (Mangifera caesia Jack. Ex. Wall) mengandung senyawa flavonoid dan fenolik yang memiliki aktivitas sebagai antioksidan dengan sebesar 16,14 ppm dengan kategori sangat kuat, sehingga dapat dikembangkan dalam bentuk sediaan masker gel peel off. Penelitian ini bertujuan untuk menentukan karakteristik fisik formulasi dan stabilitas paling optimal dari sediaan masker gel peel off berdasarkan variasi film forming PVA dan plasticizer PEG 400 dikombinasikan dengan gelling agent Na-CMC yang digunakan. Hasil penelitian menunjukan bahwa pada pengujian organoleptis sediaan memiliki warna hijau tua, hijau, hijau muda, bentuk sediaan yang sama yaitu semi solid, bau khas, serta homogen dan memiliki waktu mengering dalam rentang 15-27 menit, elastisitas masker 9,76-15,3 cm, nilai pH 6,23-6,5, daya sebar 4,7-6,5 cm dan viskositas 17746-19380 mPa.s. Pada uji waktu mengering, elastisitas, pH, daya sebar dan viskositas diperoleh nilai p-value (>0,05) sehingga dapat dinyatakan bahwa sebelum dan setelah freeze thaw tidak terjadi perubahan yang signifikan dan dikatakan stabil. Konsentrasi PVA dan PEG 400 yang paling optimum berdasarkan hasil uji homogenitas, waktu mengering, elastisitas, pH, daya sebar dan viskositas baik sebelum dan setelah freeze thaw adalah pada formula 3 dengan konsentrasi PVA sebesar 13,5% dan PEG 400 sebesar 6,5%.
Woman's self-realization in the system and structure of family relations
Authors: Vуsotska Olena , Falova Olena , Rysovana Liubov , Platyniuk Oksana , Bazhenov Oleksandr 
Published: January 2025

AimKnowledge and understanding of the mechanisms, conditions, factors contributing to the development of a woman’s personality and professional achievements, will enable significant assistance in achieving the state of ‘acme’, her peaks in personal, physical, professional, spiritual and moral development. The study of self-realization of women in the context of a marriage and a divorce is relevant and important for understanding their psychological state, social needs and development in modern society. Loss of psychological equilibrium under the influence of social stress and loss of family prospects determines the possibility of occurrence of pathological damage of the blood vessels of the brain. To prevent the development of complex mental and psychosomatic disorders, the issue of self-realization becomes important for women, since this allows them to fill their living space and find a new meaning in life.
In this aspect, it is interesting and relevant to determine the probability/lack of self-realization in women with different marital status depending on their psycho-emotional, individual, psychological and behavioral patterns.Material and methodsWomen of different social status and level of self-realization participated in this study.ResultsIn the given sample, it was displayed what percentages of divorced women compared to those living in families are self-actualized in their lives.ConclusionsA mathematical model was developed to explore the probability/lack of self-realization in women, which allowed the studying of the main indicators that affect the determination of the probability of self-realization in women depending on their psycho-emotional state and individual psychological or behavioral patterns.
Radial shock wave therapy with “Intelect PRW Lite” for calcifying tendinopathy of the shoulder, comparative effectiveness with conventional physical therapy and follow up data
Authors: Simeonova Radostina Hristova , Ignatov Ignat , Ivanov Zlatin , Nanov Georgi 
Published: January 2025

AimThe effectiveness of radial shock wave therapy for treating chronic calcifying tendinopathy of the shoulder is still controversial concerning the doses, methods and follow up. The purpose of the study is to reveal the criteria for effective treatment of this pathology and to compare it with the conventional physical factors.Material and methodsThe research has been taken on 60 people, A control group (CG), including 30 people, treated with basic therapy and experimental group (EG). including 30 people, treated with the same basic therapy and RSWT once per week for seven consecutive weeks. The effect of the treatment was shown by: sonographic examination before and after treatment, physical tests for motor skills in shoulder region, scale of pain and the range of motion (ROM).ResultsThe results have high statistical significance (p<0,001) for both groups. The comparision between EG and CG (p<0,001) proves that usage of RSWT reduces the pain quicker and restores mobility in the shoulder region in a shorter period than conventional physical therapy and only in the EG there is reduction in the parameters of the calcifications and total disappearance in the follow up.ConclusionsThe results have high statistical significance (p<0,001) for both groups. The statistical difference between EG and CG (p<0,001) proves that usage of RSWT reduces the pain quicker and restores mobility in the shoulder region in a shorter period than conventional physical therapy and only the patients in the EG have reduction in the parameters of the calcifications and total disappearance in the follow up.
Immunohistochemical Evaluation of GATA-3 in Patients with Urinary Bladder Cancer
Authors: Hameed Randa Saad , Almudhafar Rihab Hameed , Mahdi Liwaa Hussein 
Published: January 2025

AimBackground: urinary bladder cancer is a disturbing malignant disorder which participates about 3% to the recent development of cancer field. The etiology and pathogenesis can be related to environmental and occupational agents. Transformation of normal urothelial cell to a neoplastic one occurs through complicated sequences of molecular proceedings termed as epithelial plasticity. Aims: to analyze expression levels of GATA-3 in bladder tumor tissues and to prove a relation between expression of GATA-3 and clinicopathological characteristics of bladder tumors, including patient age, sex, tumor grade, and muscle invasion.Material and methodsMaterials and methods: Forty Formalin fixed paraffin embedded FFPE tissue blocks obtained from bladder tumor by transurethral resection are collected from teaching hospitals at Al-Najaf governorate. Those blocks are stained by using hematoxylin and eosin stain. Histopathological features were examined and then immunostained by GATA-3.ResultsResults: Evaluation of GATA-3 expression in urothelial carcinoma, revealed GATA-3 test was (positive) in thirty-four samples of urothelial carcinoma, while GATA-3 test was (negative) in twenty-one samples of urothelial carcinoma. Correlation of GATA-3 with other variables (age, sex, and grade) was a statistically non-significant.ConclusionsConclusion: GATA-3 is an Immunohistochemical sensitive marker to diagnose urothelial carcinoma. GATA-3 expression showed non-significant relation with age, gender and histopathological parameters and its expression has been observed to be lost or reduced in substantial proportion in relation to urothelial carcinoma. This alteration or down regulation of GATA-3 is correlated with higher tumor grade and stage.