bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational and In vitro Elucidation of Indolenine-barbituric Acid Zwitterions as Potential Chemotherapeutical Agents
Authors: Ong Kang Kit , Ramle Abdul Qaiyum , Ng Min Phin , Lim Siew Huah , Sim Kae Shin , Tan Chun Hoe 
Published: February 2024

Introduction:
The continuous pursuit of novel chemotherapeutical agents with improved
efficacy and reduced adverse effects remains a critical area of research despite advancements in
chemotherapy. We have previously synthesized indolenine and barbituric acid zwitterion scaffolds
1–10 sustainably; however, their precise chemotherapeutical properties are still lacking.

Methods:
In this present work, we conducted in silico ADMET analyses, molecular docking calculations,
DNA binding studies, and cytotoxicity assays on these zwitterions.

Results and Discussion:
Among the 10 zwitterions, zwitterion 3 bearing a methoxy group demonstrated
the highest drug-likeness score, low toxicity, as well as no violation of Lipinski’s rule of five
and Veber’s rule. Both molecular docking calculations and DNA binding studies suggested that the
minor groove of DNA is the most probable molecular target of 3 among the others (i.e., topoisomerase
and tubulin). In addition, zwitterion 3 exhibited selective cytotoxicity against a wide array of
human cancer cell lines without noticeable effect against the normal human colon fibroblast CCD-
18Co.

Conclusion:
Overall, these preliminary findings from our combined computational and experimental
strategy suggested that 3 remains promising for further elaboration as a chemotherapeutic agent.
Borderline Brenner Tumor of the Ovary in a Postmenopausal Woman: A Rare Case with Concomitant Endometrial Hyperplasia and Endocervical Polyp
Authors: Kumar Naina , Pradeep Immanuel , Srirambhatla Annapurna , Poojitha K. , Mangla Mishu 
Published: February 2024

Introduction:
Bordeline Brenner tumors of the ovary are rare tumors accounting for 2% of
all ovarian tumors and are characterized by the presence of papillary structures covered with transitional
epithelium without or minimal stromal invasion.

Case Presentation:
In the present case report a 60-year-old postmenopausal woman presented with
complaints of lower abdominal pain and a right ovarian mass of 4x5cm, which was diagnosed on histopathological
examination as borderline Brenner tumor of the ovary. There were coexisting nonatypical
endometrial hyperplasia and endocervical polyps of 1.2x0.9x0.6cm, indicating endometrial
hyperstimulation as a result of estrogen secreted by the tumor. The patient was managed successfully
with staging laparotomy and was diagnosed with stage I borderline Brenner tumor with non-atypical
endometrial hyperplasia and benign endocervical polyp.

Conclusion:
Borderline Brenner tumors are rare tumors of ovaries with uncertain malignant potential.
They have no precise predictive markers but are known to produce estrogen. Surgery remains the
mainstay of treatment for these tumors.
Unravelling the Impact: Pulmonary Side Effects of Anti-Seizure Medications
Authors: Butera Ambra , Pirrone Martina , Accetta Arianna Santina , Consoli Carla , Nicotera Antonio Gennaro , Turriziani Laura 
Published: February 2024

Background:
Epilepsy is a chronic brain condition affecting over 50 million people
worldwide. Several new anti-seizure medications (ASMs) have been introduced to treat epilepsy
in recent decades.

Objective:
Nearby the specific therapeutic action, ASMs, like other types of pharmacotherapy,
can produce various side effects. In this review, we shall analyze the different pharmaceutical
classes of ASMs, their mechanism of action, and their interaction with the respiratory system.

Methods:
This manuscript is based on a retrospective review of English publications indexed by
Pubmed, UpToDate and datasheets published by the European Medicines Agency and the Food
and Drug Administration (FDA), using various terms reminiscent of ASMs and pulmonary function.

Results:
ASMs act on organism homeostasis in different ways, acting on lung function directly
and indirectly and playing a protective or damaging role. A damaging direct lung involvement
ranged from infections, hypersensitivity reactions, and respiratory depression to other structured
pulmonary diseases. Meanwhile, a damaging indirect effect, might be constituted by pulmonary
artery hypertension. On the other hand, a protective effect might be the expression of developmental
processing, decreasing airway remodelling in asthma patients, vascular remodelling in pulmonary
hypertension and, nonetheless, anti-inflammatory and immunomodulatory actions.

Conclusion:
An adequate awareness of ASMs effects on the respiratory system seems essential
for better managing frail individuals or/and those predisposed to respiratory disorders to improve
our patients' clinical outcomes.
An Insight into the Repurposing of Phytoconstituents obtained from
Delhi’s Aravalli Biodiversity Park as Antifungal Agents
Authors: Kaur Amanpreet , Sharma Kalicharan , Sharma Neetika , Aggarwal Geeta 
Published: February 2024

Abstract:
The global prevalence of fungal infections is alarming in both the pre- and postCOVID period. Due to a limited number of antifungal drugs, there are hurdles in treatment
strategies for fungal infections due to toxic potential, drug interactions, and the development
of fungal resistance. All the antifungal targets (existing and newer) and pipeline molecules
showing promise against these targets are reviewed. The objective was to predict or repurpose
phyto-based antifungal compounds based on a dual target inhibition approach (Sterol-14-αdemethylase and HSP-90) using a case study. In pursuit of repurposing the phytochemicals as
antifungal agents, a team of researchers visited Aravalli Biodiversity Park (ABP), Delhi, India,
to collect information on available medicinal plants. From 45 plants, a total of 1149 ligands
were collected, and virtual screening was performed using Schrodinger Suite 2016 software
to get 83 hits against both the target proteins: Sterol-14-α-demethylase and HSP-90. After
analysis of docking results, ligands were selected based on their interaction against both the
target proteins and comparison with respective standard ligands (fluconazole and ganetespib).
We have selected Isocarthamidin, Quercetin and Boeravinone B based on their docking score
and binding interaction against the HSP-90 (Docking Score -9.65, -9.22 and -9.21, respectively) and 14-α-demethylase (Docking Score -9.19, -10.76 and -9.74 respectively). The docking protocol was validated and MM/GBSA studies depicted better stability of selected three
ligands (Isocarthamidin, Quercetin, Boeravinone B) complex as compared to standard complex. Further, MD simulation studies were performed using the Desmond (67) software package version 2018-4. All the findings are presented as a case study for the prediction of dual
targets for the repurposing of certain phytochemicals as antifungal agents.
A Review on Recent Patents for Oil Mist Separation Devices
Authors: Li Yunfeng , Xu Xinming , Li Ming , Li Ruoxuan , Zhang Hang , Tian Ao 
Published: February 2024

:
Oil mist separation technology and oil mist separation devices are indispensable
components of modern industry and engines and are important means to improve air quality and
reduce oil mist diffusion. However, in the study of their separation efficiency and oil droplet
collection, there are still some techniques that need breakthroughs to be able to better separate oil
mist in the future.

:
Through the introduction and discussion of the patent characteristics of oil mist separation devices in
recent years, some valuable conclusions are summarized, and future research and development have
been prospected.

:
The patents of various separation devices were studied, and the patents and research prospects of oil
mist separation devices were summarized.

:
With the development of the machinery industry, oil mist separation has become more and more
important, so a separation device is required to realize the separation, collection, recycling, and
utilization of oil mist.

:
By elaborating on the structural characteristics of the separation device, the importance of the
separation device is discussed. By comparing these patents, it is concluded that electrostatic
separators and composite separation devices are the main development trends of future separation
devices.
Potential Correlation between Gene Mutations and Metabolic Changes in
Acute Myeloid Leukemia
Authors: Jiang Aili , Hou Zhiying , Yu Bingyan , Wang Ning , Zhang Bin 
Published: February 2024

Abstract:
Acute myeloid leukemia (AML) is a common type of leukemia. However, the understanding
of AML remains insufficient. The pathological progression of AML is closely related to chromosome
abnormalities and genetic mutations. Gene mutation is an important factor in the pathogenesis
of AML and a potential cause of drug resistance. Recent studies have shown that gene mutations in
AML can cause metabolic changes. Metabolites, as downstream products of human physiological
activities, can amplify physiological and disease-related signals. Therefore, the analysis of metabolite
markers related to gene mutations can be used for early prediction of the occurrence of the disease.
This review describes the types and significance of AML gene mutations and analyzes the characteristics
of metabolic changes related to gene mutations.
Fault Section Localization Method for Distribution Network based on Synchronous Phasor Measurement
Authors: Fu Yu , Li Yue , Xiao Xiaobing , Liu Shuo , Cai Yongxiang , Liu Hao 
Published: February 2024

Background:
The accurate locating of fault sections in a distribution network can lay
an effective foundation for the rapid processing of faults. However, the waveform of highresistance
grounding faults is relatively weak, which increases the difficulty of fault feature extraction
and localization. In addition, the complex operating conditions and interference factors of
the actual distribution network can affect the fault section localization method, leading to incorrect
location problems.

Objective:
In order to overcome the limitations of existing fault section localization methods on
fault resistance values and application scenarios, a fault section localization method for distribution
networks based on synchronous phasor measurement is proposed in this paper.

Methods:
Firstly, the transient zero sequence equivalent network of single-phase to ground faults
in the distribution network is analyzed, revealing the differences in zero-sequence current within
different sections of the faulty line. At the same time, based on the zero-sequence current waveform
recorded by the waveform measurement device in actual distribution network, the characteristics
of the waveform in different sections in the time and frequency domains are analyzed. Furthermore,
a fault feature extraction method based on wavelet packet transform is proposed to construct
fault differential features for different sections. Then, the grey correlation analysis method is
adopted to calculate the correlation coefficients between different sections to construct locating
criteria, thereby achieving accurate locating of fault sections in distribution network.

Results:
The experimental results using field data indicate that the localization accuracy can reach
98.90%, and the calculation time is about 102.65 ms, which has high localization accuracy and
localization efficiency.

Conclusion:
Through analysis and relevant experiments, it is concluded that the proposed method
can accurately locate faults in actual distribution networks, and still has correct locating results for
high resistance grounding faults. The effectiveness of the method has been verified.
Fractional Trigonometric Function Approximations in a Regular System
Authors: Boucherma Djamel 
Published: February 2024

Introduction:
Linear fractional differential equations of the commensurable order, specifically
those related to fractional trigonometry, pose challenges in terms of analytical solutions.

Methods:
The purpose of this article is to present a novel approximate analytical technique to
solve linear fractional differential equations of the commensurable order, which are related to
fractional trigonometry. This method is used to obtain approximate solutions by forming linear
combinations of appropriate fractional basic functions, for which Laplace transforms are irrational
functions. This approximation technique enables us to represent these functions using timeinvariant
linear system models. Also, the implementation of analog circuits of these basic fractional
order systems can be obtained using approximation of rational functions.

Results:
The research demonstrates the efficacy and precision of this method through illustrative
examples, showcasing its effectiveness in solving linear fractional systems.

Conclusion:
The newly introduced approximate analytical method presents a promising approach
to solving linear fractional differential equations of the commensurable order, providing accurate
solutions and possibly offering applications in various fields.
An Insight into Synthetic Strategies, SAR Study and Anticancer Mechanism of Chalcone Derivatives: Medicinal Chemistry Perspective
Authors: karati Dipanjan , Kumar Dileep 
Published: February 2024

Abstract:
Chalcone derivatives continue to captivate medicinal chemists due to their modest
chemistry, facile synthetic method, and promising biological activities. They have become wellknown
in the therapeutic and pharmaceutical industries due to their diverse biological actions.
These complexes offer different features and applications in a human biological system due to
the flexibility of the reactions, including antimicrobial, antineoplastic, antimalarial, and other
uses. As a result, chalcones have sparked much attention in malignancy research. Cancer is
characterized by uncontrollably growing and spreading abnormal cells and aberrant cell behavior.
These masses destroy surrounding normal tissue and can attack vital organs, leading to
widespread disease. Cancer is frequently used as a warning sign for impending patient death. In
the age of pharmaceutical chemistry, it is unavoidably a cause for concern and a growing
weight on the populace. The pathophysiology of all malignancies is due to faulty genes that
regulate the development, division, and death of cells. Various genetic and environmental variables
combine to cause mutations in genes encoding essential cell-regulatory proteins, leading
to the numerous alterations that characterize the evolution of cancers. Rather than directly targeting
DNA synthesis, the new generation of anticancer medications target signals that promote
or control the cell cycle, growth factors and their receptors, signal transduction pathways, and
pathways impacting DNA repair and death. Drug hunters are focusing their attention on chalcone
derivatives with varying chemical structures since they are essential in the search for anticancer
drugs. Chalcone's anticancer action may be attributed to molecular changes such as drug
efflux protein activities, activation of apoptosis, DNA and mitochondrial damage, inhibition of
angiogenesis, tubulin inhibition, and kinase inhibition. Chalcones are used to diagnose cancer as
well. The development of chalcone congeners as a prodrug or prime chemical to combat cancer
necessitates a thorough investigation. This review gives an update on the different pharmacological
activities of natural and synthesized chalcones in recent years. Furthermore, the structure-
activity connections and processes are extensively documented, providing essential design
and synthesis assistance in the future.
Motion Signal-based Recognition of Human Activity from Video Stream
Dataset Using Deep Learning Approach
Authors: Yadav Ram Kumar , Arockiam Daniel , Bhaskar Semwal Vijay 
Published: February 2024

Background:
Human physical activity recognition is challenging in various research
eras, such as healthcare, surveillance, senior monitoring, athletics, and rehabilitation. The use
of various sensors has attracted outstanding research attention due to the implementation of
machine learning and deep learning approaches.

Aim:
This paper proposes a unique deep learning framework based on motion signals to recognize
human activity to handle these constraints and challenges through deep learning (e.g., Enhance
CNN, LR, RF, DT, KNN, and SVM) approaches.

Method:
This research article uses the BML (Biological Motion Library) dataset gathered from
thirty volunteers with four various activities to analyze the performance metrics. It compares
the evaluated results with existing results, which are found by machine learning and deep
learning methods to identify human activity.

Result:
This framework was successfully investigated with the help of laboratory metrics with
convolutional neural networks (CNN) and achieved 89.0% accuracy compared to machine
learning methods.

Conclusion:
The novel work of this research is to increase classification accuracy with a lower
error rate and faster execution. Moreover, it introduces a novel approach to human activity
recognition in the BML dataset using the CNN with Adam optimizer approach.
HelloFresh: Transitioning to a plastic-free future?
Authors: Sharda Nikita , Krampe Caspar , Ingenbleek Paul T.M. 
Published: February 2024

Abstract
The packaging practices of HelloFresh have come under scrutiny in recent years as a result of the company’s remarkable expansion success. Customers have cancelled their meal-kit subscriptions due to the excessive use of plastic packaging for ingredients. In response to these events, HelloFresh began to seek alternatives to replace plastic packaging for its ingredients, but ultimately found that the currently available packaging technology makes it impossible to eliminate plastic completely. HelloFresh is therefore looking for ways to communicate with customers about its sustainability message and their actions to be cost-effective, retain food-safety, and foster sustainability with regard to packaging while making innovative changes in its packaging processes. In the current stage of the sustainability transition for packaging materials in which no ready-at-hand solutions are available, it is crucial for HelloFresh to strike a balance between converting its packaging practices to be more sustainable and communicating this message effectively to its customers.
ANALISIS PENGGUNAAN SERAT IJUK TERHADAP SIFAT MEKANIS BETON NORMAL
Authors: Koesoema Hansen Chandra , Kushartono Widodo 
Published: February 2024

Concrete is a mixture of cement, coarse aggregate, fine aggregate, water and or without admixture or additional mixed ingredients. There are various types of concrete, one of which is fibrous concrete. Fibrous concrete is a composite structure consisting of ordinary concrete and other materials in the form of fibers. In this research using a mixture of palm fiber with an average diameter of 0.24 mm. The treatment method is carried out by 5 days of immersion in water followed by steam for less than 5 hours. This research uses a volume variation of 1%, 2%, 3% with lengths of 2 and 3 cm palm fiber, respectively. Based on this research, it is known that the use of a mixture of palm fiber in concrete can increase the value of tensile strength and flexural strength with the addition of the percentage of palm fiber. the use of palm fiber mixed into concrete is produced by a length of 2 cm with a percentage of 1% with a percentage increase of 1.01% in compressive strength, a percentage of 2% with a percentage increase of 76.7% in tensile strength, and a length of 3 cm with a percentage of 3% with a percentage increase of 39.8% in flexural strength.
Abstrak
Beton merupakan campuran dari semen, agregat kasar, agregat halus, air, dan atau tanpa admixture atau bahan campuran tambahan. Ada bermacam macam jenis beton salah satunya beton berserat. Beton berserat merupakan bagan komposit yang terdiri dari beton biasa dan bahan lain yang berupa serat. Pada riset ini menggunakan campuran serat ijuk dengan diameter rata rata sebesar 0,24 mm. metode perawatan dilakukan dengan 5 hari perendaman dengan air dilanjutkan steam selama kurang 5 jam. Riset ini menggunakan variasi volume 1%, 2%, 3% dengan panjang serat ijuk berturut turut sepanjang 2 dan 3 cm. diketahui berdasarkan riset ini penggunaan campuran serat ijuk pada beton dapat meningkatkan nilai kuat tarik dan kuat lentur seiring penambahan persentase serat ijuk. penggunaan serat ijuk yang di campurkan ke dalam beton dihasilkan oleh Panjang 2 cm dengan persentase 1% dengan persentase peningkatan 1,01% pada kekuatan tekan, persentase 2% dengan persentase peningkatan 76,7% pada kekuatan tarik, dan Panjang 3 cm dengan persentase 3% dengan persentase peningkatan 39,8% pada kekuatan lentur.
ANALISA CACAT PENYUSUTAN MATERIAL FCD450 DAN ALUMINIUM A356 PADA PROSES PENGECORAN STANG PISTON DINDING TIPIS MENGGUNAKAN SIMULASI
Authors: Cahaya Nicolas Hary , Yamin Lubis Sobron , Riza Abrar 
Published: February 2024

Metal castings are generally used to manufacture machine parts with complex shapes, including the manufacture of thin wall components. Thin wall casting (TWC) is a casting method for producing lightweight component objects by thinning the component walls such as plates or parts of the cast object that can be thinned. Thin wall ductile iron (TWDI) is nodular cast iron, casted through TWC. TWDI makes nodular cast iron possible to compete with aluminum when compared to the weight between these two materials. The application of aluminium to TWC aluminum will lead to lighter components production. The main reason aluminum is replacing cast iron in the automotive field is the inability or lack of interest on the part of cast iron manufacturers to produce lightweight iron components, which is TWDI. The use of simulation in the casting process helps to show the whole process in casting. This research was conducted to determine the effect of using the TWC design made for nodular cast iron on aluminum and the defects formed by using this design through software simulation. The casting design used uses Sulamet-Ariobimo et al. casting design [10] which has succeeded in producing connecting rod components using TWDI on an industrial scale. The simulation software used is the Altair Inspire Cast simulation (serial number: 680344) owned by PT. Wisma Teknik Lestari. Simulations were carried out for both FCD450 and A356 materials. Based on the results of the shrinkage simulation, there are shrinkage defects in the TWDI material and there are no shrinkage defects in Aluminum A356. This is due to the solidification characteristics and cooling rate of the two materials, where the cooling rate for TWDI is 3.84E+4 J, and 8.85E+4 J for Aluminum A356. In addition, based on the solid fraction simulation results, there are hotspots on cast components for TWDI materials which result in shrinkage defects in the components
Vulnerabilidad biopsicosocial y control reproductivo
Authors: Padilla Sierra Cindy Milena 
Published: February 2024

En las últimas décadas la anticoncepción ha sido practicada con los artilugios producidos por el modelo biomédico, entre los cuales uno de los más confiables y recomendados es el anticonceptivo hormonal (AH) de uso exclusivamente femenino. En este trabajo exploraremos cómo este fármaco afecta el bienestar biopsicosocial de algunas personas que los usan y cómo estas afecciones constituyen una vulnerabilidad gestada o producida por la biomedicina.