bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRÁTICA DO ENFERMEIRO NO MANEJO DAS TERAPIAS ALTERNATIVAS FRENTE A DOR CRÔNICA
Authors: Adriana Oliveira Magalhães  , Dayane Santos Oliveira Costa  , Leidiane Cristina Gomes Metelo  , Luana Pontes da Silva  , Vera Lúcia da Silva  
Published: February 2024

As terapias alternativas são consideradas opções eficazes de cuidado e terapia em condições de dores severas. Admite-se que sua prática traga conforto e devolva qualidade de vida ao paciente. Este estudo teve por objetivo analisar a prática do enfermeiro no manejo as terapias alternativas frente a dor crônica. Foi uma pesquisa descritiva, qualitativa e exploratória. A coleta de dados foi realizada após aprovação pelo CEP – Comitê de Ética em Pesquisa do UNIVAG – Centro Universitário de Várzea Grande, após assinatura do Termo de Consentimento Livre e Esclarecido (TCLE). A pesquisa foi realizada através de aplicação de questionário semiestruturado via Google Forms com 07 profissionais que se dispuseram a participar do estudo. Diante das respostas, as categorias com análise de conteúdo foram Percepção dos Enfermeiros na Dor Crônica, Impactos da Dor Crônicas na Vida das Pessoas, Benefícios da Terapia Alternativa para a Dor Crônica, Enfrentamentos dos Profissionais no Cuidado à Dor Crônica pela Terapia Alternativa, e Importância da Utilização de Instrumentos para mensuração da Dor, pelas quais identificou-se o conhecimento dos profissionais, suas técnicas, benefícios e dificuldades no manejo das terapias alternativas frente aos processos de dor crônica, assim como a colaboração do enfermeiro na retomada e manutenção de qualidade de vida das pessoas portadoras de dores crônicas. A pesquisa demonstrou que o enfermeiro na atenção ao cuidado da dor crônica através das terapias alternativas pode contribuir ao processo de retorno à melhora e à qualidade de vida de indivíduos com dor crônica junto à família e sociedade.
Penataan Ruang Perkotaan di Gresik Masa Pemerintahan Bupati Sambari Halim Radianto tahun 2010-2020
Authors: Sulaiman Muhammad , Sasmita Nurhadi 
Published: February 2024

Penelitian ini membahas Penataan Ruang Perkotaan di Gresik Masa Pemerintahan Bupati Sambari Halim Radianto Tahun 2010-2020. Permasalahan penelitian adalah apa faktor yang menyebabkan perlunya penataan Kota Gresik, bagaimana proses penataan ruang kota di Gresik, dan apa upaya Bupati Sambari Halim Radianto dalam mengelola dan menata ruang kota di Gresik tahun 2010-2020. Metode sejarah digunakan untuk rekonstruksi peristiwa, yang meliputi heuristik, kritik, interpretasi dan historiografi. Sumber kajian berasal dari arsip, laporan, buku, jurnal, dan karya penelitian lainnya yang relevan. Teori yang digunakan adalah teori perencanaan tata ruang. Hasil penelitian menunjukkan bahwa, penataan Kota Gresik awalnya pada kepemimpinan Bupati Soefelan tahun 1973-1978, dengan melakukan pemindahan pusat pemerintahan, rumah dinas bupati, dan seluruh kantor instansi yang ada. Penataan kota selanjutnya dilakukan oleh Bupati Robbach Ma’sum tahun 2000-2010, dengan membagi sistem permukiman perkotaan sesuai dengan hirarki dan fungsi kota. Herarki dibagi atas tiga bagian, Kota Orde I, Kota Orde II, dan Kota Orde III. Tahun 2010, Sambari Halim Radianto terpilih menjadi bupati, kemudian kembali melakukan penataan kota. Penataan kota dengan memindahkan Gedung DPRD, Mapolres, dan membangun Mall Pelayanan Publik untuk keperluan pelayanan masyarakat. Bupati Sambari juga membuat landmark sebagai identitas Kota Gresik. Landmark tersebut adalah Tugu Lontar yang terletak di Putat Luar, Sukorame. Kedua adalah Tugu Gajah Mungkur yang terletak di sudut perlimaan Sukorame. Ketiga, Tugu Menara Gardu Suling yang terletak di Pulopancikan, Kec. Gresik. Keempat, adalah Tugu Keris Sumilang Gandring. Hasil penelitian menunjukkan bahwa penataan Kota Gresik dilaksanakan masa Bupati Sambari. Penataan kota berguna untuk meningkatkan daya tarik kota dan meningkatkan perekonomian masyarakat.
Surgical Handover Core Outcome Measures (SH-CORE): A protocol for the development of a core outcome set for trials in surgical handover
Authors: Ryan Jessica M , Devane Declan , Simiceva Anastasija , Eppich Walter , Kavanagh Dara O , Cullen Christine , Hogan Aisling M , McNamara Deborah A 
Published: February 2024

Abstract

Background
Surgical handover is associated with a significant risk of care failures. Existing research displays methodological deficiencies and little consensus on the outcomes that should be used to evaluate interventions in this area This paper reports a protocol to develop a core outcome set (COS) to support standardisation, comparability, and evidence synthesis in future studies of surgical handover between doctors.
Methods
This study adheres to the Core Outcome Measures in Effectiveness Trials (COMET) initiative guidance for COS development, including the COS-Standards for Development (COS-STAD) and Reporting (COS-STAR) recommendations. It has been registered prospectively on the COMET database and will be led by an international steering group that includes surgical healthcare professionals, researchers, and patient and public partners. An initial list of reported outcomes was generated through a systematic review of interventions to improve surgical handover (PROSPERO: CRD42022363198). Findings of a qualitative evidence synthesis of patient and public perspectives on handover will augment this list, followed by a real-time Delphi survey involving all stakeholder groups. Each Delphi participant will then be invited to take part in at least one online consensus meeting to finalise the COS.
Ethics and dissemination
This study was approved by the Royal College of Surgeons in Ireland (RCSI) Research Ethics Committee (202309015). Results will be presented at surgical scientific meetings and published in peer-reviewed journals. A plain English summary will be disseminated through national websites and social media. The authors aim to integrate the COS into the handover curriculum of the Irish national surgical training body and ensure it is shared internationally with other postgraduate surgical training programmes. Collaborators will be encouraged to share the findings with relevant national health service functions and national bodies.
Discussion
This study will develop the first published COS for interventions to improve surgical handover, the first use of a real-time Delphi survey in a surgical context, and will support the generation of better-quality evidence to inform best practice.
Trial registration
Core Outcome Measures in Effectiveness Trials (COMET) initiative registration number 2675. Available at http://www.comet-initiative.org/Studies/Details/2675.
Longitudinal Assessment of Circulating Tumor DNA: A Proposed Statistical Framework
Authors: Pretz Christopher R. , Liao Jiemin , Weipert Caroline , Bucheit Leslie , Drusbosky Leylah , Das Amar 
Published: February 2024

Abstract
As circulating tumor DNA (ctDNA) levels can reflect disease progression, achieving a comprehensive understanding of the temporal evolution of ctDNA is key to informing clinical decision making. However, temporal changes can exhibit complex non-linear patterns and differ substantially across patients. Additionally, patient characteristics and outcomes may impact temporal change. Thus, traditional statistical approaches may be inadequate in characterizing ctDNA evolution over time. In this proof-of-concept study, we propose utilizing a new approach using a hierarchical random effects cubic spline model, which is sufficiently flexible to capture complex temporal ctDNA patterns while supporting the integration of patient characteristics. To demonstrate the benefits of the approach, a retrospective cohort of non-small cell lung cancer patients who received anti-EGFR therapies was analyzed. Model results are presented graphically in the form of patient-level response patterns, where each combination of patient characteristics produces a unique pattern. Patients with various ages, levels of health status, as well as mortality status were contrasted, where results provide examples of how the model can further our conceptualization of ctDNA dynamics and demonstrates how results can be used in targeted, patient-centered, clinical decision-making.
Sperm miR-142-3p reprogramming mediates paternal stress-induced non-alcoholic steatohepatitis in offspring rats
Authors: Wang Hui , Zhang Cong , Guo Yu , Liu Yi , Liu Kexin , Hu Wen 
Published: February 2024

Abstract
Although epidemiological data suggest a strong association between paternal adverse environmental exposure and susceptibility to multiple diseases in offspring, the sperm-to-liver pathway involved in offspring disease is complicated and worthy of further exploration. Caffeine contained in many beverages is regarded as a chronic stressor, and exerts reproductive and developmental toxicity. Effects of paternal pre-pregnant caffeine exposure (PPCE) on the long-term health of offspring and the underlying mechanisms remain unclear. This study innovatively reported the occurrence and transgenerational inheritance of PPCE-induced non-alcoholic steatohepatitis (NASH) in offspring, and aimed to elucidate its sperm reprogramming mechanism and the potential intervention targets. Male rats were administrated with caffeine (15 ~ 60 mg/kg/d) by gavage for 8 weeks before mating. Symptoms of NASH were found in two successive generations of male rats (F1 and F2) whose fathers or grandfathers (F0) were exposed to caffeine. RNA-seq was employed to screen out a novel miRNA mediating equilibrant of liver fatty metabolism: miR-142-3p. Role of sperm miR-142-3p in PPCE-induced offspring NAFLD was validated by in vitro fertilization of the sperm of PPCE or miR-142-3pKO sperm with normal oocytes. Overexpression of miR-142-3p in offspring liver reversed NASH manifestation in PPCE male offspring. We further proved that caffeine-induced paternal chronic stress (high glucocorticoid level) but not caffeine itself is the main cause of methylation changes in sperm and offspring NAFLD, via experiments in vitro and glucocorticoid receptor blockade. Moreover, the linkage between serum high glucocorticoids and sperm miR-142-3p low programming was also verified in clinical samples. Overall, we demonstrated for the first time that PPCE induced NASH in offspring with transgenerational inheritance, confirmed the reprogramming mechanism of sperm miR-142-3p, and identified miR-142-3p as a potential intervention target for paternal-derived NASH.
Chemodiversity and trypanocidal activity of the essential oils of tropical black sage
Authors: de Medeiros Elisabeth Alves Duarte Pereira , Nascimento Rayssa Vicente , Duarte-Junior Eduardo Barros , Pereira Camila da Silva Barbosa , Moreira Ygor Nunes , Torre Rafael , Velez Afonso Santine Magalhães Mesquita , Decote-Ricardo Debora , de Lima Marco Edilson Freire , Santos André Marques dos , Damasceno-Junior Pedro Corrêa , de Souza Marco Andre Alves 
Published: February 2024

Abstract
Tropical black sage (Varronia curassavica Jacq.) is a species native to ecosystems subject to strong anthropic action, and thus is at risk of genetic erosion. However, little is known about this important genetic resource, with possible uses in the aromas, fragrances and pharmaceutical sectors. The objective of this work was to prospect and study native specimens of tropical black sage regarding the concentration, chemical profile and trypanocidal activity of the essential oils (EOs). For this purpose, we collected in situ 47 specimens. The EOs were obtained by distillation from leaves, quantified, and analyzed by GC-FID and GC-MS. The resulting data were submitted to descriptive statistical and multivariate analyses. The concentration of EOs ranged from 0.3 to 4.2% based on dry leaves. The EOs had average contents of 33.4 and 44.9% of oxygenated and non-oxygenated sesquiterpenes, respectively. The concentration of the substance α-humulene varied from 0.3 to 11.1%, with frequency of 100%. Cluster analysis indicated the formation of 10 groups with 50% similarity among the EOs samples. The sample with the best trypanocidal activity was ESB45, with IC50% of 74.6 µg/mL and 100% inhibition of the viability of the epimastigote form of Trypanosoma cruzi at the concentration of 300 µg/mL. Tropical black sage is a source of oxygenated sesquiterpenes, an important chemical class for synthesis and development of medicines. For this reason, efforts are necessary to preserve the genetic information about the species.
Research on road performance and crack extension law of cement-phosphogypsum-red clay under dry and wet cycle
Authors: Jian Hao , Chen Kaisheng , Liu Zeyu 
Published: February 2024

Abstract

Aiming at the special engineering properties of red clay and the waste phenomenon of phosphogypsum solid waste resources, cement was used as the curing agent and SCA-2 as the water stabiliser to investigate the unconfined compressive strength characteristics, CBR characteristics, water stability and fissure extension law of cement-phosphogypsum-red clay under the action of dry and wet cycles, and the water stability mechanism was also explored in terms of the microstructure and mineral composition. The results show that the cement-phosphogypsum-red clay unconfined compressive strength decreases with the increase of the number of wet and dry cycles, with a large decay in the first three wet and dry cycles, and a gentle decay thereafter. The water stability of cement-phosphogypsum-red clay without SCA-2 water stabiliser was poor, and the specimens were basically destroyed after immersed in water for 3 min; the water stability of cement-phosphogypsum-red clay mixes was significantly improved with the addition of 5% dosage of SCA-2 water stabiliser. The cement-phosphogypsum-red clay CBR values increased and then gradually levelled off as the age of the curing period progressed, with the CBR value at 14 days being approximately 95% of that at 28 days.Cement-phosphogypsum-red clay under dry and wet cycling has good resistance to fracture development. The strength of cement-phosphogypsum-red clay (cement 5%, phosphogypsum 47.5%, red clay 47.5%, SCA-2 water stabiliser 5%) under dry and wet cycles meets the specification requirements, with good water stability performance and non-development of fissures, and it can be used as a filler for the bed of highway and first-class highway road base.
Development and Simulation Analysis of an Efficient Cooling System for Injection- Molded Plastic Components
Authors: Dhoble Pankaj Ganeshrao , Deshmukh Ravindra Raosaheb , Manuel Austin , Mahajan Sushant 
Published: February 2024

Abstract
The Injection Moulding (IM) process holds a pivotal role in plastic manufacturing, and the cooling phase, taking up nearly half of the entire cycle time, is of particular significance. The effectiveness of cooling channels plays a crucial role, exerting a substantial impact on both the quantity of production and the standard of the component. In Given the increasing prevalence of additive manufacturing (3D Printing), a viable solution to address this issue involves creating moulds with conformal cooling. This method enables accurate regulation of temperature distribution uniformity throughout the plastic solidification process in molding operations. This study is cantered around the design and simulation of various conformal cooling channel types, including hybrid, zig-zag, spiral and porous configurations. These are compared with traditional straight cooling methods for a plastic part. The comparative analysis encompasses parameters such as mould ejection temperature, shrinkage, Warpage, temperature profiles to determine which configuration is better suited for achieving uniform cooling with minimal cycle time. The investigation utilizes SolidWorks Simulation Moldflow Analysis software to scrutinize the performance outputs of the cooling channels.
The ghost of oysters past: museomics reveals isolation, low diversity and adaptive signatures of an extinct oyster population
Authors: Ewers Christine , Brandis Dirk , Silva Nicolas Antonio da , Hayer Sarah , Immel Alex , Moesges Zoe , Susat Julian , Torres-Oliva Montserrat , Krause-Kyora Ben 
Published: February 2024

Abstract
Understanding the factors that predispose species and populations to decline and extinction is a major challenge of biodiversity research. In the present study, we investigated the historical population genomics of an extinct oyster population from the Wadden Sea collected between 1868 and 1888, and compared it to French and British populations sampled at the same time. The Wadden Sea is a unique habitat on the northern edge of the European oyster distribution. Our museomic results indicate that the now-extinct population was genetically isolated and had a lower nuclear genomic diversity than the examined French and British populations. Furthermore, genome scans revealed signatures of local adaptation, and population-specific divergence in several loci linked to fitness-relevant traits. The Wadden Sea oysters may have been predisposed for extinction because they were not naturally replenished from other populations, and the small population size did not allow them to adapt to anthropogenically-driven environmental change. In addition, anthropogenic translocations could not successfully replenish or replace this population because these foreign oysters may have been unable to reproduce in the unique Wadden Sea habitat. In summary, the Wadden Sea oysters exhibited all intrinsic drivers expected in a population predisposed for extinction.
Fibroblast Dynamics and NR2F2 Pathway in the Development of Mouse Radiation Induced Skin Fibrosis
Authors: Wan Derrick , Abbas Darren , Griffin Michelle , Guo Jason , Berry Charlotte , Valencia Caleb , Guardino Nicholas , Lavin Christopher , Fahey Evan , Kameni Leo , Momeni Arash , Januszyk Michael , Longaker Michael 
Published: February 2024

Abstract
Radiation induced skin fibrosis (RIF) is a debilitating sequela of radiation therapy. Fat grafting represents a primary therapeutic option, but its mechanism remains unknown. We aimed to delineate the cellular contributions to RIF and their part in the evolution of this disease. Furthermore, as fat grafting represents a therapeutic option employed clinically, we explored how this strategy may impact prevalence of various cellular subpopulations and pathways involved. C57BL/6J and ActinCre/ROSA26VT2/GK3 mice underwent radiation wounding and mice were euthanized at weeks 0, 2, 4, and 8 following radiation. Fibrosis had a temporal response from week 0 to 8 with progressive increases in dermal thickness and collagen density along with changes to extracellular matrix organization and loss of vascularity. Tissue-resident cells expanded clonally in response to radiation injury. With single cell RNA sequencing, five transcriptionally distinct fibroblast subpopulations were identified, creating the first murine atlas for RIF. Dynamic alterations in subpopulation prevalence were appreciated in fat grafted mice, and downregulation of the NR2F2 pathway was associated with improvement of RIF.
Spatial shift of small pelagic fish in North-West Africa related to long-term intense warming and local decrease in marine productivity
Authors: SARRE Abdoulaye , DEMARCQ Hervé , KEENLYSIDE Noel , KRAKSTAD Jens-Otto , AYOUBI Salaheddine EL , JEYID Ahmed Mohamed , FAYE Saliou , MBAYE Adama , SIDIBEH Momodou , BREHMER Patrice 
Published: February 2024

Abstract
Along the coast of North-West Africa, fish supply is important at both socio-economic and cultural levels while threatened by climatic changes. To assess the impact of climate change on the distribution of small pelagic fish, a comprehensive trend analysis was conducted using data from 2,363 trawl samplings and 170,000 km of acoustics sea surveys spanning the period 1995–2015. The approach included estimating eight northern small pelagic species' presence and acoustics spatial distribution of the sardinella. The analysis incorporated key environmental variables, including sea temperature, chlorophyll-a concentration, and a wind-based Ekman upwelling index. The Southern Canary Current Large Marine Ecosystem (CCLME) was divided into five distinct ecological areas, extending from Morocco to Senegal, providing a spatialized perspective on the dynamic changes unfolding within these characteristic areas. Then, yearly averages of the monthly data per area were calculated. Strong warming is reported in all five areas. Over 34 years, from 1988 to 2021, several discernible trends emerged, with the southern CCLME experiencing increases in both wind speed and upwelling intensity, particularly in areas where the coastal upwelling was already the strongest. Despite upwelling-induced cooling mechanisms, sea surface temperature increased in most areas, indicating the complex interplay of climatic-related stressors in shaping the marine ecosystem. Concomitant northward shifts in the distribution of sardinella and other species were attributed to long-term warming trends in sea surface temperature (SST). As a result, the abundance of Sardinella aurita, the most abundant species along the coast, has increased in the subtropics (north part) and fallen in the intertropical region (south part). Independent environmental and ecological observational time series confirm a northward shift of around 180 km in one decade for S. aurita, while S. maderensis did not move significantly. Spatial shifts in biomass from 30 to 145 kilometers were observed for six other exploited small pelagic species, similar to those recorded for surface isotherms. An intensification in upwelling intensity within the northern and central regions of the system is documented without change in marine primary productivity. In contrast, a stable upwelling intensity is reported in the southern region (Senegal), which is associated with a decline in primary productivity. These environmental differences were associated with several small pelagic species beyond national boundaries whose recent overexploitation adds a new threat to their sustainable future in the whole region. Such changes must motivate common regional policy considerations for food security and sovereignty in all West African countries sharing the same stocks.
Evaluation of Maternal Patient Experience Through Natural Language Processing Techniques: The Case of Twitter Data in The United States During COVID-19
Authors: Banik Debapriya , Madathil Sreenath Chalil , Lopes Amit Joe , Fong Sergio A. Luna , Mukka Santosh K. 
Published: February 2024

Abstract
Purpose
The healthcare sector constantly investigates ways to improve patient outcomes and provide more patient-centered care. Delivering quality medical care involves ensuring that patients have a positive experience. Most healthcare organizations use patient survey feedback, such as HCAHPS, to measure patients' experiences. The power of social media can be harnessed using artificial intelligence and machine learning techniques to provide researchers with valuable insights into understanding patient experience and care. Our primary research objective is to develop a social media analytics model to evaluate the maternal patient experience during the COVID-19 pandemic.
Method
We used the "COVID-19 Tweets" Dataset, which has over 28 million tweets, to evaluate patient experience using Natural Language Processing (NLP) and extract tweets from the US with words relevant to maternal patients. The maternal patient cohort was selected because the United States has the highest percentage of maternal mortality and morbidity rate among the developed countries in the world.
Results
We created word clouds, word clustering, frequency analysis, and network analysis of words that relate to “pains” and “gains” regarding the maternal patient experience, which are expressed through social media.
Conclusion
This model will help process improvement experts without domain expertise understand various domain challenges efficiently. Such insights can help decision-makers improve the patient care system. We also conducted a preliminary study to discover if a particular group faces racial health inequity.