bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood pressure lowering effects of Vernonia amygdalina Del. Aqueous fraction on hypertensive Wistar Kyoto rats
Authors: Juwita Dian Ayu , Farinka Rindang , Abdillah Rahmad , Rachmaini Fitri 
Published: October 2023

Abstract

Objectives
Vernonia amygdalina (VA) is a plant that consumed as vegetable by Indonesians contained numerous secondary metabolites. VA’s pharmacological action, including its antioxidant properties, anticancer, antidiabetic, and hepatoprotective. The purpose of this research is to reveal the activity of Vernonia amygdalina. leafs aqueous fraction (VALAF) as a blood pressure-lowering agent in hypertensive model.

Methods
Combination of prednisone and NaCl were used as hypertensive inducer. The animals were split into five different groups, normal control group treated with distilled water, treatment VALAF groups with dose of 10; 20 and 40 mg/kg BW respectively, while the last group was treated with captopril at dose of 2.25 mg/kg BW. All animals were given an oral treatment for 15 days. On days 5, 10, and 15, systolic and diastolic blood pressure, heart rate (HR), mean arterial pressure (MAP), and blood flow (BF) were all measured. On days 0 and 15, NO level were assessed. All data were analyzed using two-way ANOVA, and Duncan Multiple Range Test.

Results
The V. amygdalina leaf aqueous fraction has blood pressure lowering activity. The blood pressure parameter of the rats treated with VALAF were lower as compared to the normal control group (p<0.05). NO levels in the VALAF group were not significantly higher than in the normal control group (p>0.05). The VALAF 20 give the greatest percentage of decrease in blood pressure, heart rate and blood volume on the 15th day of examination.

Conclusions
These study indicated that V. amygdalina leaf aqueous fraction has the potential to be an alternative therapy for managing blood pressure in hypertensive animal models.
Causes of adverse outcomes in acute intestinal obstruction
Authors: Madyarov Valentin , Kuzikeev Marat , Malgazhdarov Maulen , Abzalbek Yestay , Zhapbarkulova Gulnara 
Published: October 2023

Abstract

Objectives
The purpose of this study is to analyse the effectiveness of methods of diagnosis and treatment of patients with acute intestinal obstruction.

Methods
A total of 123 patients were examined, who were diagnosed based on history, an overview X-ray of the abdominal cavity, a contrast examination of the intestine, and contrast marks according to Yu. L. Shalkov and irrigoscopy. 57.4 % of patients had all typical aspects of the disease, 17.7 % – indolent aspects, and 4.8 % – atypical. In the case of colonic obstruction, the method of irrigoscopy is informative. To restore intestinal function, patients with acute intestinal obstruction of the small intestine are indicated with a Yu. L. Shalkov nasogastroenteral tube or a double-drainage nasointestinal tube. And with the colonic form of the disease, it is necessary to perform a Hartmann-type operation and establish a Maidl-type anastomosis.

Results
It was noted that with indolent or atypical aspects of the disease, patients received medical care late. It is shown that in the case of resection of necrotic areas of the intestine, it is informative to determine the resection boundary using the vasoscopy method using a 1 % aqueous solution of methylene blue. It was found that the optimal distance from the edge of the resection is 3 cm.

Conclusions
The results of this study are of interest to clinicians who are engaged in the diagnosis and treatment of patients with acute intestinal obstruction.
Paradise Found or Common Sense Lost? Göbekli Tepe’s Last Decade as a Pre-Farming Cult Centre
Authors: Banning Edward B. 
Published: October 2023

AbstractThe spectacular finds at Turkey’s Göbekli Tepe have fired the imaginations of archaeologists and the general public alike. Reflecting on developments at and about the site since the 2011 publication of a critique of the site’s dominant interpretation as a hunter-gatherer cult centre, this article shows that some elements of that critique, including assertions about roofing and a residential population, have gained traction, while others have fallen on deaf ears. Göbekli Tepe has also become the locus of discussion and speculation in disciplines ranging from astronomy and religion to psychology and architectural history, while also inspiring pseudoscientific claims that associate the site with the Garden of Eden, a supposed technologically sophisticated pre-Holocene civilization or extraterrestrial visitors.
Mortality among papillary thyroid cancer patients by detection route: a hospital-based retrospective cohort study
Authors: Wu Lan , Vaccarella Salvatore , Feng Chen-Yang , Dal Maso Luigino , Chen Yu , Liu Wei-Wei , Liang Miao-Bian , Zhang Zike , Yang Jun , Cao Su-Mei , Li Mengmeng 
Published: October 2023

Background
Incidence rates of papillary thyroid cancer (PTC) have increased rapidly, with incidentally detected cancers contributing a large proportion. We aimed to explore the impact of incidental detection on thyroid cancer-specific and competing mortality among PTC patients.

Methods
We conducted a retrospective cohort study of PTC patients at a cancer center in Guangzhou. Baseline information on detection route and other covariates were collected between 2010 and 2018, and death outcome was followed up for each patient. Cumulative incidence functions were used to estimate the mortality risk of thyroid cancer and competing risk. Cause-specific hazard models were then utilized to explore the association between detection routes and PTC-specific and competing mortality.

Results
Of the 2874 patients included, 2011 (70.0%) were detected incidentally, and the proportion increased from 36.9% in 2011 to 82.3% in 2018. During a median follow-up of 5.6 years, 42 deaths occurred, with 60% of them due to competing causes. The probability of competing mortality at 5 years in the non-incidental group and incidental group was 1.4% and 0.4%, respectively, and PTC-specific mortality in the non-incidental group and incidental group was 1.0% and 0.1%, respectively. After adjusting for covariates, the HRs of incidental detection were 0.13 (95% CI: 0.04–0.46; P = 0.01) and 0.47 (95% CI: 0.20–1.10; P = 0.10) on PTC-specific mortality and competing mortality, respectively.

Conclusions
Incidental detection is associated with a lower risk of PTC-specific and competing mortality. Under the context of increasing magnitude of overdiagnosis, incorporation of detection route in clinical decision-making might be helpful to identify patients who might benefit from more extensive or conservative therapeutic strategies.
Could Economic Growth Propel Costa Rica to Lessen its Environmental Debasement? Environmental Kuznets Curve (1990-2021)
Authors: Ugalde-Hernández Óscar 
Published: October 2023

According to the goals proposed and ratified by the Paris Agreement on 2015 and by the United Nations Conference on Climate Change in 2021, the world should attempt to maintain the global average temperature well below 2° above pre-industrial levels in the long run and to restrain the temperature increase to 1.5°C above pre-industrial levels. One country undertaking bold and charismatic environmental action is Costa Rica. Since the late 1960s, this country has implemented both avant-garde policymaking and practices in the environmental field.As a means of contributing with the analysis and understanding of how to determine this country’s effectiveness and efficiency in its environmental efforts, this research aims to analyze the relationship between Costa Rica’s CO2 emissions per capita with economic growth, expressed via Gross Domestic Product (GDP) per capita (constant 2015 dollars). Thus, the Environmental Kuznets Curve (EKC) hypothesis will be tested to determine if Costa Rica is a good example. Using the database from the World Bank’s (2023) World Development Indicators and from Global Change Data Lab (2023) as a basis of analysis and through the application of quantitative correlational analysis with a type of longitudinal nonexperimental design with time-series data from the year 1990 to the year 2021, it is argued that increases in CO2 emissions per capita are influenced positively with a statistical significance at a 5% error margin by GDP per capita (constant 2015 US dollars), and by energy consumption per capita. Alternatively, CO2 emissions per capita are influenced negatively with statistical significance at 5 % error margin respectively by GDP per capita squared (constant 2015 US dollars) and land use change per capita. However, these results cannot be confirmed with reliability and robustness because of the ambivalence and ambiguity present in the proposed model as a consequence of the likelihood of the presence of multicollinearity among the variables and the lack of normality of the dependent variable. Despite the initial promising results of a high goodness-of fit test, an acceptable F-statistic, the lack of heteroscedasticity, and an acceptable result showing no autocorrelation presence, the hypothesis of this study cannot be answered affirmatively. Despite these results, there is room for more research to confirm if the EKC hypothesis continues to be applicable in this country. This study could serve as a reference point for decision-makers regionally and internationally to guide their local environmental efforts towards concrete achievements for obtaining a clean planet in the future.
Reseña del libro: Global Climate Justice Theory and Practice
Authors: Agudelo-Herrera Isabella 
Published: October 2023

The book "Global Climate Justice: Theory and Practice" provides a comprehensive view of climate justice from diverse theoretical approaches by exploring diverse perspectives on the distribution of CO2 and climate responsibility. The text examines controversial viewpoints, such as the right of oil companies to receive compensation for profit losses, as well as historical approaches that consider the persistent effects of colonization on states' capacity to address climate change and the consequent responsibility of colonizing states. The review emphasizes the historical context driving the need to implement environmental justice. Additionally, it highlights the diversity of theoretical perspectives presented in the book and their relevance in formulating international policies.
Assessment of excavation slurry produced clayey mineral from the Bahr Al-Najaf region
Authors: Hussein Mahdi J. , Mohammed Kamal Ali , Naser Fatimah H. 
Published: October 2023

AbstractThis study targeted to investigate a type of excavation slurry by local available material in Najaf region. On the other hand, chief practises is supported the deep sides of foundation in particular pile foundation and, drilling oil wells. The results of slurries are checking, for seven properties, which includes the viscosity (apparent plastic and funnel Marsh), yield stress, density, acidity, and gel power (10–0 min). Which are 11.7367, 8.8733, 38.1667, 11.5467 mPa·s, 1.1045 kg m−3, 10.9067, and 11.2683 mPa·s, respectively. On the basis of the results tests for the above properties, that is possible to produce a product that conforms to the specifications of American Petroleum Institute specifications, and according to the requirements of the standard ACI 336.3R-93:2006 without additives. The rheological behavior improvement is achieved through the breakdown of the bundles of palygorskite fibers that normally make up the texture of these mudstones by increasing the time and speed of the shear force as soon as increasing the concentration of clay powder.
Processing of calcium sulfoaluminate eco-cement coatings containing microencapsulated phase change materials
Authors: Romero-Espinosa Andrea , Sanfélix Susana G. , Morales-Cantero Alejandro , Cuesta Ana , Kjøniksen Anna-Lena , Aranda Miguel A. G. , De la Torre Angeles G. , Santacruz Isabel 
Published: October 2023

On the one hand, calcium sulfoaluminate (CSA) eco-cements release about 40% less carbon dioxide (CO2) than Portland cement during fabrication; on the other hand, phase change materials dispersed in a cementitious matrix can help to optimise the indoor temperature of buildings, reducing carbon dioxide emissions related to heating/air conditioning. However, this is only economically viable if it is used as a thin layer (a coating). In addition, the combination of both materials supposes a double environmental benefit. Consequently, the main objective of this work is the preparation of a suitable homogeneous and well-adhered bilayer sample, composed of CSA and CSA-MPCM. To achieve this, in the first step, the effect of pH, temperature and stirring was studied for microencapsulated phase change material (MPCM) aqueous suspensions (47.3 wt%); second, the MPCM (45 wt% with respect to dry cement) was dispersed in a CSA paste; then, in a third step, a homogeneous well-adhered coating of CSA-MPCM, with undamaged MPCM, was obtained on a CSA matrix. This was achieved through rheological measurements and checked by microscopy. Finally, the corresponding CSA and CSA-MPCM mortars were characterised through their mechanical properties (compression) (70 and 13 MPa at 7 days, respectively) and thermal conductivity (2.06 and 1.19 W/mK, respectively).
Clinical study of 104 cases of hollow viscus perforation with peritonititis in gastric and duodenal perforation at rural tertiary centre
Authors: Tanter Pranjal , Gond Pratik , Pakkal Shreya , Thippaarapu Manideep , Dandekar Kundankumar N 
Published: October 2023

Acute abdomen with peptic ulcer perforation is a common cause of emergency admission and surgery. This is the study that documents the presentation and outcome of perforation management in DBVPRMC, Loni.This is a prospective study of patients operated upon for perforation peritonitis between March 1, 2021, and March 23, 2023. A structured recorded after questionnaire containing patients demographics, operative findings, and outcome was discharge or death.There were 104 patients. 81 males and 23 females (M : F = 3.5 : 1). The age range was between 18 years and 95 years. The mean age was 48.99 years ± SD 16.1 years. The ratio of gastric to duodenal perforation was 1.88 : 1. Perforation was the first sign of peptic ulcer disease in 62 (59.6%). Pneumoperitoneum was detectable with plain radiographs in 95 (91%) patients. 72 (69.2%) had Graham’s Omentopexy. Death rate was 17.3%.We note that gastric perforation is a more commoner disease in our environment. Perforation is often the first sign of peptic ulcer disease. We identify spicy food, alcoholism and NSAIDs intake amongst patient as a risk factor for perforation. Early presentation is associated with good prognosis.
BUSINESS ANALYSIS AND MARKETING OF TILAPIA CASE FLOATING NET CAGES IN ALANG RIVER VILLAGE, KARANG INTAN DISTRICT, BANJAR REGENCY, SOUTH KALIMANTAN PROVINCE
Authors: Dekayanti Tri , Febrianty Irma , Annisa Mira 
Published: October 2023

Alang river Village, Karang Intan District is a village that has a lot of potential in the field of fisheries, especially in the floating net cage media with the commodity of Tilapia which is commonly used by the community, this fish cultivator business is a source of income in the village by utilizing the river that stretches around Alang river village. The problem that occurs in the Jasmine Fish Cultivator Group is the death of the fish which results in many losses and problems in access to fish marketing outside the South Kalimantan area. The purpose of this research was to analyze the feasibility of the business and to analyze the marketing of rearing tilapia in POKDAKAN Melati floating net cages in Sungai Alang village. The method this research is Primary, Secondary, Interview, Observation, Snowball Sampling, and Documentation Methods. The results of this research indicate that the business run by POKDAKAN Melati is feasible and profitable to be developed with profit the average per month is Rp. 5,309,863.2 within a repayment period of 0.46 years or 5 months 16 days, with a total NPV of 7% of Rp. 418,052,002, Net BCR 7% of 1.35% and IRR value of 136.74% Meanwhile, for the marketing channels, there are 2 marketing channels, namely semi-direct channels and indirect channels with the amount of Farmer Share analysis of 78% which can be said to be efficient.

Desa Sungai Alang Kecamatan Karang Intan merupakan desa yang memiliki banyak pontensi dibidang perikanan khusus nya pada media Karamba Jaring Apung dengan komoditi Ikan Nila yang biasa digunakan masyarakat, usaha pembudidaya ikan ini merupakan sumber penghasilan yang ada di desa tersebut dengan memanfaatkan sungai yang membentang disekitaran desa sungai alang. Permasalahan yang terjadi pada Kelompok Pembudidaya Ikan Melati adalah kematian ikan yang mengakibatkan banyaknya kerugian yang dialami dan permasalahan akses pemasaran ikan untuk luar daerah Kalimantan Selatan. Tujuan penelitian ini ialah menganalisis kelayakan usaha dan menganalisis pemasaran pembesaran ikan nila pada POKDAKAN Melati Karamba Jaring Apung Desa Sungai Alang. Metode dalam penelitian ini ialah Primer, Sekunder, Wawancara, Observasi, Snowball Sampling, dan Dokumentasi. Hasil dari penelitian menunjukkan bahwa usaha yang dijalankan POKDAKAN Melati layak dan menguntungkan untuk dikembangkan dengan hasil keuntungan rata-rata per bulan nya sebesar Rp. 5.309.863,2 dalam kurun waktu pengembalian 0,46 tahun atau 5 bulan 16 hari, dengan jumlah NPV 7% sebesar Rp. 418.052.002 , Net BCR 7% sebesar 1,35 % dan nilai IRR 136,74% sedangkan untuk salurannya pemasaran didapatkan 2 saluran pemasaran yaitu saluran semi langsung dan saluran tidak langsung dengan jumlah analisis Farmer Share 78% yang mana dapat dikatakan efisien.
High Sensitivity for Detection of Primary Diagnostic Variants in Autism Spectrum Disorder, Including <em>De Novo</em> Variants, with Trio Whole Genome Sequencing and Data Reanalysis
Authors: Bar Omri , Vahey Elizabeth , Mintz Mark , Frye Richard Eugene , Boles Richard Gregory 
Published: October 2023

Autism spectrum disorder (ASD) is a common condition with lifelong implications and a strong hereditary component suggesting genetic underpinnings. The last decade has seen dramatic improvements in DNA sequencing and related bioinformatics and databases.
We analyzed the raw DNA sequencing files on the Variantyx® bioinformatics platform for the last 50 ASD patients evaluated with trio whole genome sequencing (trio-WGS). “Qualified” variants were defined as coding, rare, and evolutionarily conserved. Primary Diagnostic Variants (PDV) additionally were in genes directly linked to ASD and matched clinical correlation.
A PDV was identified in 34/50 (68%) of cases, including 25 (50%) cases with heterozygous de novo and 10 (20%) with inherited variants. De novo variants in genes directly associated with ASD were far more likely to be Qualifying than non-Qualifying versus a control group of genes not associated with ASD (P = 0.0002, odds ratio 29), validating that most are indeed disease related. Only 14/34 (41%) of PDV cases had the variant listed on the laboratory report, and reanalysis increased diagnostic yield from 28% to 68%. Variants that we assigned as PDVs yet not on the report were predominately de novo in genes not yet reported as ASD associated. Many subjects both with and without a PDV had inherited Qualifying variants in known ASD-associated genes, suggesting polygenic inheritance. Thirty-three subjects (66%) had treatment recommendation(s) based on DNA analyses.
Our results demonstrate high yield of trio-WGS for revealing molecular diagnoses in ASD that is greatly enhanced by re-analyzing DNA sequencing files. In contrast to previous reports, de novo variants dominate the findings, mostly representing novel conditions. This has implications to the cause and rising prevalence of autism.
KESALAHAN PENERAPAN HUKUM SEBAGAI ALASAN KASASI TINDAK PIDANA TURUT SERTA MEMALSUKAN SURAT SECARA BERLANJUT
Authors: Raflyansyah Arief Agha , Septiningsih Ismawati 
Published: October 2023

<em>This legal research aims to find out the misapplication of the law by the District Court Judge as the reason for the Public Prosecutor's cassation against the acquittal in the criminal case of participating in forging letters related to the provisions of Article 253 paragraph (1) of the Criminal Procedure Code and the suitability of the Supreme Court's consideration in examining and deciding the Public Prosecutor's cassation in Supreme Court Decision Number 1086 K/Pid/2022. This legal research is a prescriptive and applied normative legal research with a case study approach. The source of legal material for this research comes from primary legal materials and secondary legal materials. The legal material collection technique used is document study or literature study. The technique of analyzing legal materials in this study uses the syllogism method with deductive thinking patterns. The results of the research and discussion obtained are that the Public Prosecutor can prove the suitability of the reasons for cassation submitted by him with the reasons for cassation contained in Article 253 paragraph (1) of the Criminal Procedure Code, namely in terms of whether it is true that a legal rule is not applied or applied improperly. Therefore, the Supreme Court granted the cassation of the Public Prosecutor and found the defendant guilty of committing the crime charged, then imposed a prison sentence of 6 (six) month.</em><p><em>Keywords: <a href="/verstek/article/view/73134">Cassation, Mail Forgery, Acquittal Decision.</a></em></p>
KESESUAIAN PERTIMBANGAN HAKIM DALAM PUTUSAN NOMOR 1/Pid.Sus-Anak2022/PN BYL DENGAN UU SPPA
Authors: Muharam Azzam Zaid , Santoso Bambang 
Published: October 2023

<p><em>This writing analyzes the suitability of the judge's considerations in imposing a prison sentence of two years and three months of job training for children with Article 71 paragraph (3) and Article 79 of the Law of the Republic of Indonesia Number 11 of 2012 concerning the Juvenile Justice System. In Decision Number 1/Pid.Sus-Anak/2022/PN Byl it is known that there has been a criminal act of sexual intercourse with a child, which was committed by a child. Child offenders are subject to Article 81 paragraph (2) of Law Number 17 of 2016 concerning Stipulation of Government Regulation in lieu of Law Number 1 of 2016 regarding the second amendment to Law Number 23 of 2002 concerning Child Protection. The Child Protection Act can be applied to anyone, regardless of whether the offender is an adult or a child. So to protect child perpetrators, the Law of the Republic of Indonesia Number 11 of 2012 concerning the Juvenile Justice System is enacted. The purpose of this writing is to find out whether the judge's considerations in Decision Number 1/Pid.Sus-Anak/2022/PN Byl are in accordance with the Law of the Republic of Indonesia Number 11 of 2012 concerning the Juvenile Justice System. As a result, the judge in his considerations before making a decision had considered Article 71 paragraph (3) of the Law of the Republic of Indonesia Number 11 of 2012 concerning the Juvenile Justice System.</em></p><p> <em>Keywords: <a href="/verstek/article/view/73217">Consideration; Intercourse; Child</a></em></p>