bluuebunny/crossref_metadata_2025_split huggingface dataset:
STAREE-Mind Imaging Study: a randomised placebo-controlled trial of atorvastatin for prevention of cerebrovascular decline and neurodegeneration in older individuals
Authors: Harding Ian H , Ryan Joanne , Heritier Stephane , Spark Simone , Flanagan Zachary , McIntyre Richard , Anderson Craig S , Naismith Sharon L , Chong Trevor T-J , O'Sullivan Michael , Egan Gary , Law Meng , Zoungas Sophia 
Published: November 2023

IntroductionCerebrovascular disease and neurodegeneration are causes of cognitive decline and dementia, for which primary prevention options are currently lacking. Statins are well-tolerated and widely available medications that potentially have neuroprotective effects. The STAREE-Mind Imaging Study is a randomised, double-blind, placebo-controlled clinical trial that will investigate the impact of atorvastatin on markers of neurovascular health and brain atrophy in a healthy, older population using MRI. This is a nested substudy of the ‘Statins for Reducing Events in the Elderly’ (STAREE) primary prevention trial.MethodsParticipants aged 70 years or older (n=340) will be randomised to atorvastatin or placebo. Comprehensive brain MRI assessment will be undertaken at baseline and up to 4 years follow-up, including structural, diffusion, perfusion and susceptibility imaging. The primary outcome measures will be change in brain free water fraction (a composite marker of vascular leakage, neuroinflammation and neurodegeneration) and white matter hyperintensity volume (small vessel disease). Secondary outcomes will include change in perivascular space volume (glymphatic drainage), cortical thickness, hippocampal volume, microbleeds and lacunae, prefrontal cerebral perfusion and white matter microstructure.Ethics and disseminationAcademic publications from this work will address the current uncertainty regarding the impact of statins on brain structure and vascular integrity. This study will inform the utility of repurposing these well-tolerated, inexpensive and widely available drugs for primary prevention of neurological outcomes in older individuals. Ethics approval was given by Monash University Human Research Ethics Committee, Protocol 12206.Trial registration numberClinicalTrials.gov Identifier:NCT05586750.
Qualitative study of the perceived experiences and needs coping of primary caregivers of patients with breast cancer during operation in central China
Authors: Li Min , Guo Jun , Gao Jinnan , Wang Linying , Ding Yongxia 
Published: November 2023

PurposeThe purpose of this study is to gain an in-depth understanding of the intraoperative waiting period experience and needs response of primary caregivers of patients with breast cancer.MethodUsing a purposive sampling method, 16 primary caregivers of patients with breast cancer admitted to the Department of Breast Surgery of Shanxi Bethune Hospital from January to May 2022 were selected as study subjects. Semistructured in-depth interviews were conducted using a qualitative research method.ResultsFive themes were extracted from the levels of safety and security, information transfer, emotion management, psychological adjustment and role adaptation: safety first and intraoperative care, lack of information and misdirection, negative emotions and tired of coping, ineffective worry and overthinking, and role multiplicity and bearing alone, respectively.ConclusionThe intraoperative waiting period for primary caregivers of patients with breast cancer felt multidimensional and had less than optimal needs satisfaction. Healthcare professionals should use the existing needs as an entry point to give appropriate interventions to enhance the coping ability of caregivers of patients with breast cancer.
Protocol for validating an algorithm to identify neurocognitive disorders in Canadian Longitudinal Study on Aging participants: an observational study
Authors: Mayhew Alexandra J , Hogan David , Raina Parminder , Wolfson Christina , Costa Andrew P , Jones Aaron , Kirkland Susan , O'Connell Megan , Taler Vanessa , Smith Eric E , Liu-Ambrose Teresa , Ma Jinhui , Thompson Mary , Wu Changbao , Chertkow Howard , Griffith Lauren E 
Published: November 2023

IntroductionIn population-based research, disease ascertainment algorithms can be as accurate as, and less costly than, performing supplementary clinical examinations on selected participants to confirm a diagnosis of a neurocognitive disorder (NCD), but they require cohort-specific validation. To optimise the use of the Canadian Longitudinal Study on Aging (CLSA) to understand the epidemiology and burden of NCDs, the CLSA Memory Study will validate an NCD ascertainment algorithm to identify CLSA participants with these disorders using routinely acquired study data.Methods and analysisUp to 600 CLSA participants with equal numbers of those likely to have no NCD, mild NCD or major NCD based on prior self-reported physician diagnosis of a memory problem or dementia, medication consumption (ie, cholinesterase inhibitors, memantine) and/or self-reported function will be recruited during the follow-up 3 CLSA evaluations (started August 2021). Participants will undergo an assessment by a study clinician who will also review an informant interview and make a preliminary determination of the presence or absence of an NCD. The clinical assessment and available CLSA data will be reviewed by a Central Review Panel who will make a final categorisation of participants as having (1) no NCD, (2) mild NCD or, (3) major NCD (according to fifth version of the Diagnostic and Statistical Manual of Mental Disorders criteria). These will be used as our gold standard diagnosis to determine if the NCD ascertainment algorithm accurately identifies CLSA participants with an NCD. Weighted Kappa statistics will be the primary measure of agreement. Sensitivity, specificity, the C-statistic and the phi coefficient will also be estimated.Ethics and disseminationEthics approval has been received from the institutional research ethics boards for each CLSA Data Collection Site (Université de Sherbrooke, Hamilton Integrated Research Ethics Board, Dalhousie University, Nova Scotia Health Research Ethics Board, University of Manitoba, McGill University, McGill University Health Centre Research Institute, Memorial University of Newfoundland, University of Victoria, Élisabeth Bruyère Research Institute of Ottawa, University of British Columbia, Island Health (Formerly the Vancouver Island Health Authority, Simon Fraser University, Calgary Conjoint Health Research Ethics Board).The results of this work will be disseminated to public health professionals, researchers, health professionals, administrators and policy-makers through journal publications, conference presentations, publicly available reports and presentations to stakeholder groups.
Examining the health and functioning status of medical laboratory professionals in Ontario, Canada: an exploratory study during the COVID-19 pandemic
Authors: Joncic Genavieve , Jain Mahika , Chattu Vijay Kumar , Gohar Basem , Nowrouzi-Kia Behdin 
Published: November 2023

ObjectivesThis study aims to explore the overall and specific aspects of the functioning of medical laboratory professionals (MLPs) in Ontario, Canada during the COVID-19 pandemic.DesignA cross-sectional analysis where a questionnaire was used to assess the mental status of MLPs.SettingAn online questionnaire administered in Ontario, Canada.Participants632 MLPs (medical laboratory technologists, technicians and assistants) were included.Main outcome measuresWe employed the WHO Disability Assessment Schedule V.2.0 (WHODAS V.2.0) Questionnaire to assess functioning/disability and Copenhagen Psychosocial Questionnaire, third edition for psychosocial workplace factors. Multiple regression analysis examined the relationship between overall and specific domain functioning scores and psychosocial workplace factors.ResultsOf the total 632 participants, the majority were female gender and Caucasian. It was found that health (β=2.25, p<0.001, CI: 1.77 to 2.73), management of environmental conditions (β=0.65, p<0.001, CI: 0.33 to 0.98), fear of unemployment (β=−0.72, p<0.001, CI: −1.09 to −0.35) and frequency of stress (β=−1.86, p<0.001, CI: −2.33 to −1.40), in addition to bullying exposure (β=0.56, p<0.01, CI: 0.15 to 0.98) and threats of violence exposure (β=0.90, p<0.01, CI: 0.25 to 1.54), significantly decreased functioning overall and within the specific WHODAS V.2.0 functioning domains.ConclusionThis study provides preliminary evidence of the overall and specific aspects of functioning among the MLPs during the COVID-19 pandemic. Besides, these findings can support and guide the improvement of workplace practices and policies among MLPs in the future.
Quantifying the impact of immunotherapy on RNA dynamics in cancer
Authors: Usaite Ieva , Biswas Dhruva , Dijkstra Krijn , Watkins Thomas BK , Pich Oriol , Puttick Clare , Angelova Mihaela , Thakkar Krupa , Hiley Crispin , Birkbak Nicolai , Kok Marleen , Zaccaria Simone , Wu Yin , Litchfield Kevin , Swanton Charles , Kanu Nnennaya 
Published: November 2023

BackgroundCheckpoint inhibitor (CPI) immunotherapies have provided durable clinical responses across a range of solid tumor types for some patients with cancer. Nonetheless, response rates to CPI vary greatly between cancer types. Resolving intratumor transcriptomic changes induced by CPI may improve our understanding of the mechanisms of sensitivity and resistance.MethodsWe assembled a cohort of longitudinal pre-therapy and on-therapy samples from 174 patients treated with CPI across six cancer types by leveraging transcriptomic sequencing data from five studies.ResultsMeta-analyses of published RNA markers revealed an on-therapy pattern of immune reinvigoration in patients with breast cancer, which was not discernible pre-therapy, providing biological insight into the impact of CPI on the breast cancer immune microenvironment. We identified 98 breast cancer-specific correlates of CPI response, including 13 genes which are known IO targets, such as toll-like receptorsTLR1,TLR4, andTLR8, that could hold potential as combination targets for patients with breast cancer receiving CPI treatment. Furthermore, we demonstrate that a subset of response genes identified in breast cancer are already highly expressed pre-therapy in melanoma, and additionally we establish divergent RNA dynamics between breast cancer and melanoma following CPI treatment, which may suggest distinct immune microenvironments between the two cancer types.ConclusionsOverall, delineating longitudinal RNA dynamics following CPI therapy sheds light on the mechanisms underlying diverging response trajectories, and identifies putative targets for combination therapy.
Distinction and prognosis of early arthritis phenotypes: an analysis in three European cohorts
Authors: Sepriano Alexandre , van Dijk Bastiaan , Ramiro Sofia , van der Helm-van Mil Annette , Combe Bernard , van Schaardenburg Dirkjan , de Wit Maarten , Kent Alison , Mateus Elsa , Landewé Robert 
Published: November 2023

ObjectivesThe objective of this study is to evaluate whether there are differences in the long-term prognosis across various phenotypes of early arthritis (EA).MethodsThree EA cohorts (Reade, Etude et Suivi des Polyarthrites Indifférenciées Récentes (ESPOIR) and Early Arthritis Clinic (EAC)) were analysed. Clinical data were collected up to 24 years. Hands and feet radiographs were scored according to the Sharp van der Heijde (SvdH) method. Latent class analysis was applied to determine the EA phenotypes at baseline. Each class received a label reflecting its most prominent features. Prognostic outcomes included Health Assessment Questionnaire (HAQ), Short Form 36 (SF36) and SvdH score. The association between class membership and outcomes over time was tested in multivariable models.ResultsIn total, 390 (Reade), 798 (ESPOIR) and 3991 (EAC) patients were analysed separately. Two classes with symmetrical polyarthritis emerged; one of these labelled as autoimmune inflammatory polyarthritis (AIPA), had high likelihood of acute phase reactants (APR) elevation and autoantibody positivity, while the other (mild-inflammatory polyarthritis; MIPA) had not. A third class had oligoarthritis of upper limbs (OAUL) and could be subdivided into autoimmune OAUL and mild-inflammatory OAUL. A fifth class had oligoarthritis of lower limbs. The SvdH scores were worse in patients with APR/autoantibodies (AIPA) than in those without (MIPA). No clinically meaningful differences across classes in HAQ or SF36 over time were found.ConclusionRadiographic progression over time primarily occurs in EA patients with APR/autoantibodies. The absence of these markers, however, does not necessarily translate into better long-term function and quality of life. Clinicians should not only aim at preventing joint damage, but look beyond structural progression in order to further improve the lives of people with EA.
Factors associated with compartment syndrome after a tibial fracture in children
Authors: Ahmed Nasim , Kuo Yen-Hong 
Published: November 2023

ObjectivesCompartment syndrome (CS) after a tibial fracture in children is one of the orthopedic emergencies. Identifying high-risk patients in a timely fashion minimizes morbidities. This study aimed to find the risk factors of CS after a tibial fracture.MethodsThe study data was retrieved from the Trauma Quality Improvement Program database of the calendar year 2017–2019. All patients aged <18 years old who were admitted to the hospital with tibial fractures were included in the study. Patients’ characteristics, including demography, injury, injury severity, and associated crushed and vascular injuries were analyzed between the groups who developed CS versus those who did not develop CS after a tibial fracture. Multiple logistic regression analyses were performed to find the association of CS. All p values are two-sided and a p value<0.05 is considered statistically significant.ResultsOf 4492 patients who qualified for the study, 49 (1.1%) patients developed CS. The patients who developed CS sustained more crush injuries and were associated with a higher rate of vascular injury (2% vs 0.1%, p=0.043% & 10.2% vs 2.2%, p=0.005). Multivariable analysis showed that for every increase in 1 year of age, the odds of occurrence of CS increased by 15.7% (adjusted OR (AOR)=1.157, 95% CI: 1.032 to 1.297, p=0.013). Non-African American race was associated with more than double the risk of developing CS when compared with the African American race, AOR was 2.238, (95% CI: (1.08 to 4.638)). The associated crush injury had an approximately 19-fold higher risk of CS when compared with patients presented with no crush injury, AOR was 18.812, (95% CI: (1.513 to 233.931)). Associated vascular injury was found to have significantly higher AOR, 3.509, 95% CI: (1.287 to 9.563) of CS.ConclusionIncreased age, non-African American race, vascular injury, and crushed injury were associated with a risk of developing CS after a tibial fracture.Level of evidence: IVStudy type: Observational cohort study.
Brain signal variability and executive functions across the life span
Authors: Goodman Zachary T. , Nomi Jason S. , Kornfeld Salome , Bolt Taylor , Saumure Roger A. , Romero Celia , Bainter Sierra A. , Uddin Lucina Q. 
Published: November 2023

Abstract
Neural variability is thought to facilitate survival through flexible adaptation to changing environmental demands. In humans, such capacity for flexible adaptation may manifest as fluid reasoning, inhibition of automatic responses, and mental set-switching—skills falling under the broad domain of executive functions that fluctuate over the life span. Neural variability can be quantified via the BOLD signal in resting-state fMRI. Variability of large-scale brain networks is posited to underpin complex cognitive activities requiring interactions between multiple brain regions. Few studies have examined the extent to which network-level brain signal variability across the life span maps onto high-level processes under the umbrella of executive functions. The present study leveraged a large publicly available neuroimaging dataset to investigate the relationship between signal variability and executive functions across the life span. Associations between brain signal variability and executive functions shifted as a function of age. Limbic-specific variability was consistently associated with greater performance across subcomponents of executive functions. Associations between executive function subcomponents and network-level variability of the default mode and central executive networks, as well as whole-brain variability, varied across the life span. Findings suggest that brain signal variability may help to explain to age-related differences in executive functions across the life span.
Mouthparts of the crab Goniopsis cruentata (Latreille, 1803) (Decapoda, Brachyura, Grapsidae): morphological variations associated with environment, sex and stage of development
Authors: Soares-Silva Ana Carla , da Conceição Guerreiro Couto Erminda , Carvalho Fabrício Lopes 
Published: November 2023

Abstract
Individuals and populations can display variations in distinct aspects of their life histories, which could be reflected in their morphological characteristics. This study analyzed the mouthpart morphology of the crab Goniopsis cruentata in relation to environment, sex and stage of development. Our results indicate differences in the number of setae between developmental stages and environments, as well as the interaction between developmental stages and environments. There were no differences in setae types between stages, sexes or environments. There were differences in the shape of the ischium between adults and juveniles, with a more homogeneous ischium in juveniles than adults. We also found differences in food content between developmental stages, as well as an interaction between developmental stages and environment. Our results support an association between diet and morphology of mouthparts in G. cruentata, and that these apparatuses vary according to ontogenetic development and the environmental conditions that species are exposed to. These associations should be considered in studies that use these characteristics to verify morphological responses to environmental variations.
Observations of Boundary Layer Convergence Lines and Associated Updrafts in the U.S. Southern Great Plains
Authors: Liu Shanhe , Sindhu Kapil D. , Kirshbaum Daniel J. 
Published: November 2023

Abstract
Boundary layer convergence lines (CLs) are highly effective at deep-convection initiation (DCI), suggesting that their associated updraft properties differ from those of more widespread turbulent updrafts in the planetary boundary layer (PBL). This study exploits observations at the Atmospheric Radiation Measurement Southern Great Plains (ARM SGP) observatory in Oklahoma from 2011 to 2016 to quantify CL properties and their relation to turbulent PBL eddies preceding CL arrival. Two independent methods for estimating CL properties are developed at two locations in the SGP region, both relying on the assumption of a 2D circulation in the CL-normal plane but using different combinations of instruments. The first (the radar method) relies mainly on scanning radar data and is applied to 61 CLs passing near a high-resolution scanning radar based in Nardin, Oklahoma, while the second (the surface method) relies mainly on surface wind data and is applied to 68 CLs crossing the SGP facility in nearby Lamont, Oklahoma. Mean daytime (1000–1900 LST) CL width (∼2 km) and convergence magnitude (∼0.003 s−1) are similar for both methods, and mean daytime CL depth is ∼0.75 km. The two methods disagree at night (0000–1000 and 1900–2400 LST), where the surface method estimates wider and weaker CLs than the radar method. This difference may stem from the radar beam overshooting the shallow, highly stable nocturnal PBL. The largest CL updrafts are slightly wider (∼20%) and stronger (∼40%) than the largest PBL updrafts in the pre-CL period, generating 50%–100% larger updraft mass fluxes over most of the PBL depth.

Significance Statement
Deep convection is commonly initiated by boundary layer convergence lines (CLs), which are associated with intense surface-based wind convergence and strong updrafts that may lift air to saturation. Although CLs form regularly, they are far less common than ordinary, short-lived turbulent thermals in the daytime boundary layer. To better understand why CLs are so effective at deep-convection initiation, we observationally quantify their morphologies and strengths and compare these properties to those of surrounding turbulent updrafts. Perhaps surprisingly, the CLs are found to exhibit only slightly larger scales and strengths as the turbulent updrafts. Although these marginal increases help to explain the preference for storms to initiate along CLs, they likely are not the whole story.
The Vertical Structure of Internal Lee-Wave-Driven Benthic Mixing Hotspots
Authors: He Ying , Hibiya Toshiyuki 
Published: November 2023

Abstract
In global ocean circulation and climate models, bottom-enhanced turbulent mixing is often parameterized such that the vertical decay scale of the energy dissipation rate ζ is universally constant at 500 m. In this study, using a nonhydrostatic two-dimensional numerical model in the horizontal–vertical plane that incorporates a monochromatic sinusoidal seafloor topography and the Garrett–Munk (GM) background internal wave field, we find that ζ of the internal lee-wave-driven bottom-enhanced mixing is actually variable depending on the magnitude of the steady flow U0, the horizontal wavenumber kH, and the height hT of the seafloor topography. When the steepness parameter (Sp = NhT/U0 where N is the buoyancy frequency near the seafloor) is less than 0.3, internal lee waves propagate upward from the seafloor while interacting with the GM internal wave field to create a turbulent mixing region with ζ that extends farther upward from the seafloor as U0 increases, but is nearly independent of kH. In contrast, when Sp exceeds 0.3, inertial oscillations (IOs) not far above the seafloor are enhanced by the intermittent supply of internal lee-wave energy Doppler-shifted to the near-inertial frequency, which occurs depending on the sign and magnitude of the background IO shear. The composite flow, consisting of the superposition of U0 and the IOs, interacts with the seafloor topography to efficiently generate internal lee waves during the period centered on the time of the composite flow maximum, but their upward propagation is inhibited by the increased IO shear, creating a turbulent mixing region of small ζ.