bluuebunny/crossref_metadata_2025_split huggingface dataset:
LCMS: An R package for automated semitargeted analysis in lipidomics
Authors: Peltier Caroline , Vasku Glenda , Crépin Marine , Cabaret Stephanie , Berdeaux Olivier 
Published: January 2024

AbstractWhile nontargeted analysis aims to profile and report the relative distributions of a wide range of molecules from different lipid classes/subclasses, its major challenge is the annotation and identification of the molecules. Semitargeted analysis circumvents the problem by establishing a (potentially large) list of molecules to be targeted in the samples that are identified before the analysis. This approach is particularly adapted for lipid analysis to help with the automation of lipid annotation and identification. However, the manual extraction of peaks for many molecules and many samples is time consuming. Consequently, an automation of these extractions is deeply required. This paper presents a free R package for the automation of semitargeted analysis for lipid analysis. From raw files collected with LC‐MS device and a list of molecules to target (containing their class), it automatically returns Excel files containing the intensities for each targeted molecule and each sample. This package allows a fast computation of the intensities. Furthermore, it guarantees the reproducibility of the results and is freely available and user‐friendly.Practical Applications: With the help of the R package presented in this paper, the use of semitargeted lipidomics as an alternative to untargeted analysis should be investigated by more labs. Work on the comparisons between the approaches could be conducted. While untargeted methods are mostly used, they require long pretreatments and identification of molecules of interest. On the contrary, in semitargeted analysis, once the integration table and retention time are obtained, the results are fast and directly interpretable. An idea for lipidomics would be to use untargeted lipidomics to compute the integration table and retention table, then use semitargeted analysis for a fast computation of well identified molecules.
Investigation into a Tetrahydroquinazoline Scaffold
Authors: Jardner Jonathan , Bantel Leah , Claußen Marie , Christoffers Jens 
Published: January 2024

AbstractA new 5,6,7,8‐tetrahydroquinazoline (i. e. 1,3‐diazanaphthalene) scaffold with four points of diversification RA−RD was prepared. The sequence started from nitroalkanes RCCH2NO2 (with RC = Me, Bu), ethyl acrylate and amidines RAC(NH)NH2 (with RA = Ph, 4‐pyridyl) which were converted in a conjugate addition, Dieckmann condensation and pyrimidine ring formation. After transformation of the OH group in 4‐position to a chloro leaving group, residues RB were introduced by nucleophilic substitution with alkyl amines RBNH2 (10 examples) or aryl thiols RBSH (two examples). Finally, the nitro group in the 6‐position was reduced and the primary amino function amidated with various carboxylic acids RDCO2H. Along this seven‐step sequence, eight examples of the fully decorated scaffold were prepared.
Synthesis and Cell‐Based Evaluation of Umifenovir Analogues as Anti‐SARS‐CoV‐2 Agents
Authors: Tanaka Hiroaki , Miyagi Seiya , Morita Tomoko , Ishii Hiroaki , Mori Natsuki , Oishi Kaho , Sakaguchi Takemasa , Usuki Toyonobu 
Published: January 2024

AbstractUmifenovir is a broad‐spectrum antiviral agent used to treat influenza in China and Russia, and it has been studied as an antiviral agent for the treatment of coronavirus disease 2019 (COVID‐19). We have previously reported the synthesis of novel umifenovir analogues and their biological evaluation with a focus on their inhibitory activity against the binding of the spike glycoprotein (S‐protein) of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) and the angiotensin‐converting enzyme 2 (ACE2) receptor; however, no strong inhibitory activity was observed from these analogues. In the present study, an additional set of umifenovir analogues was synthesized with replacement of the substituents at the 2‐, 3‐, and 4‐positions of the indole, and a cell‐based assay using SARS‐CoV‐2 (B.1.1) was performed to examine the antiviral activity of the analogues. We found that one of the newly synthesized umifenovir analogues exhibited antiviral activity and reduced the viral load to 0.06 % as compared to the control when it was assessed in the presence of nafamostat and marimastat, which inhibit cell‐surface viral entry. In contrast, when this analogue was evaluated without the addition of nafamostat or marimastat, it exhibited less antiviral activity, suggesting that the umifenovir analogue would exert antiviral activity mainly by inhibiting endosome‐mediated viral entry.
Sex addiction 101: Empirical support, treatment considerations, and future directions
Authors: Drozda Natalie A. , Delmonico David 
Published: January 2024

AbstractSex addiction prevalence is estimated between 3% and 10%. There are multiple pathways to its development including biological predispositions, trauma and attachment issues, comorbid conditions, among others. Although controversy still surrounds sex addiction's conceptualization, diagnosis, and treatment, some approaches to treatment have shown promise, including cognitive behavioral therapy (CBT), acceptance and commitment therapy (ACT), and use of selective serotonin reuptake inhibitors (SSRIs). Empirical support, clinical implications, and future directions are discussed.
High‐precision Drosophila heart segmentation and dynamic cardiac parameter measurement for optogenetics‐OCT‐based cardiac function research
Authors: Zheng Fei , Wu Renxiong , Huang Shaoyan , Li Meixuan , Yuan Wuzhou , Ni Guangming , Liu Yong 
Published: January 2024

AbstractDrosophila model has been widely used to study cardiac functions, especially combined with optogenetics and optical coherence tomography (OCT) that can continuously acquire mass cross‐sectional images of the Drosophila heart in vivo over time. It's urgent to quickly and accurately obtain dynamic Drosophila cardiac parameters such as heartbeat rate for cardiac function quantitative analysis through these mass cross‐sectional images of the Drosophila heart. Here we present a deep‐learning method that integrates U‐Net and generative adversarial network architectures while incorporating residually connected convolutions for high‐precision OCT image segmentation of Drosophila heart and dynamic cardiac parameter measurements for optogenetics‐OCT‐based cardiac function research. We compared our proposed network with the previous approaches and our segmentation results achieved the accuracy of intersection over union and Dice similarity coefficient higher than 98%, which can be used to better quantify dynamic heart parameters and improve the efficiency of Drosophila‐model‐based cardiac research via the optogenetics‐OCT‐based platform.
Structures, photoluminescence, and magnetism of 1D lanthanide coordination polymers dominated on 3,5‐dichlorobenzoate
Authors: Dong Yanping , Li Li , Li Guangming , Zhang Ruijia 
Published: January 2024

AbstractTwo series of novel coordination polymers (CPs), namely, Ln3(3,5‐DCB)9(bipy) (H2O)2·(bipy) [Ln = Nd (1), Sm (2)] and Ln2(3,5‐DCB)6(bipy)H2O [Ln = Eu (3), Gd (4), Tb (5) and Dy (6)], have been synthesized by hydrothermal reaction of a bridging ligand, 3,5‐dichlorobenzoic acid (3,5‐HDCB), with LnCl3·nH2O and N‐donor neutral ligand, 2,2′‐bipyridine (bipy). Single‐crystal x‐ray diffraction, elemental analysis, IR spectroscopy, thermogravimetric analysis (TGA), and powder x‐ray diffraction (PXRD) for 1–6 are presented. CPs 1 and 2 exhibit trinuclear lanthanide architectures, in which the center Ln(III) are seven‐coordinated and eight‐coordinated adopting monocapped triangular prismatic, distorted square antiprism and bicapped trigonal prismatic coordination geometry, respectively, whereas CPs 3–6 are isostructural dinuclear structures. The center Ln(III) ions are also seven‐coordinated and eight‐coordinated with different coordinate modes adopting distorted monocapped triangular prismatic and square antiprism coordination geometry. Trinuclear CPs 1 and 2 are packed together via hydrogen‐bonding interaction to form the two‐dimensional (2D) supramolecular layers. CPs 3–6 exhibit 2D layers by the π–π interaction. CPs 2, 3, 5, and 6 display the characteristic fluorescent emissions of Sm(III), Eu(III), Tb(III), and Dy(III), respectively. CPs 1 and 4–6 exhibit corresponding weak anti‐ferromagnetic and ferromagnetic interactions of Nd(III), Gd(III), Tb(III), and Dy(III) in the low‐temperature range.
Late pregnancy maternal naringin supplementation affects the mitochondria in the cerebellum of Wistar rat offspring via sirtuin 3 and AKT
Authors: Gindri dos Santos Bernardo , Maciel August Pauline , Santos Rocha Débora , Mesquita Ismael , Menegotto Manuela , Stone Vinícius , Matté Cristiane 
Published: January 2024

AbstractDietary polyphenol consumption is associated with a wide range of neuroprotective effects by improving mitochondrial function and signaling. Consequently, the use of polyphenol supplementation has been investigated as an approach to prevent neurodevelopmental diseases during gestation; however, the data obtained are still very inconclusive, mostly because of the difficulty of choosing the correct doses and period of administration to properly prevent neurodegenerative diseases without undermining normal brain development. Thus, we aimed to evaluate the effect of naringin supplementation during the third week of gestation on mitochondrial health and signaling in the cerebellum of 21‐day‐old offspring. The offspring born to naringin‐supplemented dams displayed higher mitochondrial mass, membrane potential, and superoxide content in the cerebellum without protein oxidative damage. Such alterations were associated with dynamin‐related protein 1 (DRP1) and phosphorylated AKT (p‐AKT) downregulation, whereas the sirtuin 3 (SIRT3) levels were strongly upregulated. Our findings suggest that high dietary polyphenol supplementation during gestation may reduce mitochondrial fission and affect mitochondrial dynamics even 3 weeks after delivery via SIRT3 and p‐AKT. Although the offspring born to naringin dams did not present neurobehavioral defects, the mitochondrial alterations elicited by naringin may potentially interfere during neurodevelopment and need to be further investigated.
Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc
Authors: Zhou Jiaxiang , Wang Jianmin , Li Jianfeng , Zhu Zhengya , He Zhongyuan , Li Junhong , Tang Tao , Chen Hongkun , Du Yukun , Li Zhen , Gao Manman , Zhou Zhiyu , Xi Yongming 
Published: January 2024

AbstractBackgroundDisc degeneration is associated with repetitive violent injuries. This study aims to explore the impact of repetitive strikes loading on the biology and biomechanics of intervertebral discs (IVDs) using an organ culture model.MethodsIVDs from the bovine tail were isolated and cultured in a bioreactor, with exposure to various loading conditions. The control group was subjected to physiological loading, while the model group was exposed to either one strike loading (compression at 38% of IVD height) or repetitive one strike loading (compression at 38% of IVD height). Disc height and dynamic compressive stiffness were measured after overnight swelling and loading. Furthermore, histological morphology, cell viability, and gene expression were analyzed on Day 32. Glycosaminoglycan (GAG) and nitric oxide (NO) release in conditioned medium were also analyzed.ResultsThe repetitive one strike group exhibited early disc degeneration, characterized by decreased dynamic compression stiffness, the presence of annulus fibrosus clefts, and degradation of the extracellular matrix. Additionally, this group demonstrated significantly higher levels of cell death (p < 0.05) and glycosaminoglycan (GAG) release (p < 0.05) compared to the control group. Furthermore, upregulation of MMP1, MMP13, and ADAMTS5 was observed in both nucleus pulposus (NP) and annulus fibrosus (AF) tissues of the repetitive one strike group (p < 0.05). The one strike group exhibited annulus fibrosus clefts but showed no gene expression changes compared to the control group.ConclusionsThis study shows that repetitive violent injuries lead to the degeneration of a healthy bovine IVDs, thereby providing new insights into early‐stage disc degeneration.
A new phenotype of EVEN‐PLUS syndrome in a Chinese family and literature review
Authors: Liu Ming , Li Huanhuan , Ren Shuhong , Ding Changhong 
Published: January 2024

AbstractBackgroundEpiphyseal, Vertebral, Ear, and Nose (EVEN)‐PLUS syndrome is a rare condition characterized by the involvement of the Epiphyses, Vertebrae, Ears, and Nose, plus other associated findings, due to pathogenic variants in the HSPA9 gene. Due to the sparse number of patients, the clinical phenotypic spectrum is not clear.MethodsWe report two patients with pathogenic HSPA9 variants from a Chinese family. Besides the core clinical features of EVEN‐PLUS syndrome, the two cases had seizures, developmental delay, and basal ganglia lesions in cerebral MRI. We also reviewed the previously published reports of patients with biallelic pathogenic HSPA9 variants.ResultsTogether with the presented cases, 12 cases (9 females) were identified from 6 relevant research items for analysis. All patients had synophrys or arched eyebrows, hypoplastic or dysplastic ears, hypoplastic nasal bone, and dysplastic femoral head. Other specific craniofacial features (such as triangular nares), abnormal skeletal presentations (such as bifid femur, dysplastic epiphyses at the knee, dysplastic acetabula, delayed ossification, short stature, vertebral clefting, scoliosis, and dislocated patellae), congenital heart defects, and renal alterations are common clinical features. Two patients had seizures and basal ganglia lesions in cerebral MRI. Infrequent features, such as aplasia cutis, short thorax and sternum, and widely spaced nipples, are also observed in the syndrome. Thirteen variants associated with EVEN‐PLUS syndrome have been reported.ConclusionsHSPA9 gene mutations should be suspected in all cases with specific craniofacial features, abnormal skeletal presentations, congenital heart defects, and renal alterations. Seizures and basal ganglia lesions are a new phenotype of EVEN‐PLUS syndrome.
Design of a 2–18 GHz low noise amplifier MMIC with current reused topology
Authors: Zhang Zijian , Mou Shouxian 
Published: January 2024

AbstractA 2–18 GHz ultra wideband low noise amplifier (LNA) is illustrated in this letter. The proposed LNA adopts a two‐stage structure, which is composed of a common source amplifying stage and a cascode amplifying stage. By combining band extension matching technique, current reused topology and active bias circuit, the LNA performs excellent in gain, noise figure, power consumption, and immunization against the fluctuation of voltage supply. The LNA is implemented with a 0.18‐μm GaAs pseudomorphic high electron mobility transistor process and has a compact chip area of 1.75 × 1 mm2. The dedicated LNA achieves a measured average gain of 20.7 dB with ±1.5 dB variation all over the ultra‐wide bandwidth of 2–18 GHz. It also has a measured noise figure of lower than 1.7 dB and a measured output 1 dB compression point of higher than 5 dBm in the operating frequency band. The LNA has a low direct current power dissipation of 100 mW under a 5 V voltage supply.
Double diffusive effects on nanofluid flow toward a permeable stretching surface in presence of Thermophoresis and Brownian motion effects: A numerical study
Authors: Deepthi V. V. L. , Narla V. K. , Srinivasa Raju R. 
Published: January 2024

AbstractThe present study explores the nanofluid boundary layer flow over a stretching sheet with the combined influence of the double diffusive effects of thermophoresis and Brownian motion effects. For the purpose of transforming nonlinear partial differential equations into the linear united ordinary differential equation method, the similarity transformation technique is used. The Runge–Kutta–Fehlberg method was used to solve the equations of flow, along with sufficient boundary conditions. The effect on hydrodynamic, thermal and solutes boundary layers of a number of related parameters is investigated and the effects are graphically displayed. In conclusion, a strong agreement between the current numerical findings and the previous literature results is sought.
Enhancing stakeholder engagement in sustainable forest management: A multi‐domain comparative analysis of forest‐related beliefs, values, and behaviors of Canadian Aboriginal and non‐Aboriginal groups
Authors: Yiwen Zhang , Kant Shashi , Vertinsky Ilan 
Published: January 2024

AbstractThe study aims to understand the variations in the domain‐specific pro‐sustainable‐forest‐management behavior (PSFMBs) and their explanatory factors across ecological, economic, recreational, and Aboriginal domains and between Aboriginal and non‐Aboriginal groups. A hybrid model of PSFMB, which integrates environmental psychology and resource economics perspectives, is conceptualized and estimated using multi‐group path analysis and data from three Aboriginal and three non‐Aboriginal communities in Ontario, Canada. Results show that both groups make substantial pro‐SFM contributions, but the contributions and their influencing factors differ across domains and groups. For Aboriginals, environmental worldviews and assigned forest values are the only influencing factors, while for non‐Aboriginals, income and forest environmental conditions play dominant roles. The findings confirm the fundamental differences in the roles of beliefs, values, and situational factors in influencing the PSFMB of Aboriginal and non‐Aboriginal groups, highlight the need for theoretical lenses that account for cultural differences, and contribute to the development of inclusive policies that respect the unique values of different social groups.
DIPEA‐Assisted Efficient One‐Pot Three‐Component Synthesis of Novel β‐Carboline Tethered Pyran Derivatives
Authors: Banyal Naveen , Malakar Chandi C. , Kumar Rakesh , Singh Virender 
Published: January 2024

AbstractA potential DIPEA‐assisted approach has been unfolded for the synthesis of novel β‐carboline tethered‐4H‐pyran derivatives via one‐pot condensation of 1‐formyl‐9H‐β‐carbolines, β‐keto esters and malononitrile in ethanol at ambient temperature. A library of 28 new β‐carboline tethered 4H‐pyran derivatives has been developed. The significant features of the present strategy include high efficiency, excellent yield, inexpensive catalyst, mild reaction conditions, multicomponent character of reaction and simple purification procedure.
Null energy constraints on two-dimensional RG flows
Authors: Hartman Thomas , Mathys Grégoire 
Published: January 2024

Abstract
We study applications of spectral positivity and the averaged null energy condition (ANEC) to renormalization group (RG) flows in two-dimensional quantum field theory. We find a succinct new proof of the Zamolodchikov c-theorem, and derive further independent constraints along the flow. In particular, we identify a natural C-function that is a completely monotonic function of scale, meaning its derivatives satisfy the alternating inequalities (–1)nC(n)(μ2) ≥ 0. The completely monotonic C-function is identical to the Zamolodchikov C-function at the endpoints, but differs along the RG flow. In addition, we apply Lorentzian techniques that we developed recently to study anomalies and RG flows in four dimensions, and show that the Zamolodchikov c-theorem can be restated as a Lorentzian sum rule relating the change in the central charge to the average null energy. This establishes that the ANEC implies the c-theorem in two dimensions, and provides a second, simpler example of the Lorentzian sum rule.
Bloom’s IoT Taxonomy towards an effective Industry 4.0 education: Case study on Open-source IoT laboratory
Authors: Awouda Ahmed , Traini Emiliano , Asranov Mansur , Chiabert Paolo 
Published: January 2024

AbstractIn the rapidly evolving landscape of Industry 4.0, the demand for skilled professionals well-versed in Internet of Things (IoT) technologies is escalating. However, a significant challenge faced in educational settings is the lack of comprehensive and effective methodologies for imparting practical knowledge and skills in IoT. This paper presents an approach for designing and implementing an Internet of Things (IoT) laboratory in which students may practice and comprehend many components of an IoT environment, such as analysis of sensor data, IoT platform development, and setup of messaging protocols. The teaching methodology adopts a Cyber-Physical System (CPS) framework, which integrates teachers, classrooms, and resources to create a comprehensive learning environment. Bloom's taxonomy is employed to assess the efficacy of the suggested technique in terms of cognitive skills and knowledge acquisition. The evaluation procedure demonstrated the advantages of a hybrid learning environment, which integrated both face-to-face and remote instruction. The case study is conducted in an engineering higher education course on first year students. The findings of this paper lay the groundwork for a remotely deliverable IoT training course, contributing to the advancement of IoT education and equipping students with the necessary skills for the evolving landscape of Industry 4.0.
Property rights theory, bundles of rights on IoT data, and the EU Data Act
Authors: Eckardt Martina , Kerber Wolfgang 
Published: January 2024

AbstractWith the advance of smart IoT devices (Internet of Things) the amount of valuable data will increase dramatically. With its recently enacted Data Act (DA) the EU introduces new data access and sharing rights for the users of IoT devices. This article analyzes how the DA will change the bundle of rights on non-personal IoT data regarding who can control, access, use, share, and monetize this data. In a first step, we apply the property rights theory (esp. the approach of Barzel) for explaining the status quo of IoT data governance. Here the manufacturers can get through the technical design of their IoT devices exclusive de facto control over IoT data ("capture" of data). In a second step, we analyze how the DA changes this de facto bundle of rights in order to unlock more IoT data for innovation, competition, and empowerment of users. Since the DA is not very clear and partly contradictory, three different concepts for the design of this bundle of rights are analyzed and compared: A data holder-centric IP-like concept, a user-centric concept, and the concept of co-generated data. The article analyzes all three concepts from an economic perspective including relevant market failures regarding IoT data in B2B and B2C contexts. For achieving the objectives of the DA, especially regarding unlocking of data for innovation, bundles of rights should be chosen which reject notions of exclusivity and enable broad access and sharing of IoT data. The enacted Data Act, which still clings too much to the exclusivity of data and includes too many hurdles for data sharing, cannot be expected to contribute much to achieving these objectives.