bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the causality between regional capital expenditure and local own-source revenue in Maluku province
Authors: Rumerung Dientje , Oppier Hermi , Ramly Fahrudin , Tamtelahitu Jopie , Matitaputty Izaac Tonny 
Published: December 2023

Government initiatives to improve public services are critically necessary by taking into account the region’s entire potential. The regional government employs infrastructure development for public services by allocating funds in the form Regional Government Budget (RGB)) from the regional capital expenditure budgets. The infrastructure development allows the regional government to collect levies and taxes on to boost the Local Own-Source Revenue This study aims to investigate the causality between regional capital expenditure and Local Own-Source Revenue in 11 regencies / cities in Maluku province for a 10-year period (2011-2020). A quantitative method using a Granger causality approach was employed. The data was collected using a purposive sampling method from the Statistics Indonesia of Maluku and analysis with Multiple Linear Regression Method. The results show that there is a unidirectional relationship between the Local Own-Source Revenue and regional capital expenditure. However, there is no causal relationship between regional capital expenditure and Regional Original Income. These results indicate that capital expenditure does not indicate the funding source for Local Own-Source. The implication is that Local Own-SOurce has not been able to meet capital expenditure needs. Therefore, the ability of regional governments to optimize regional income sources through extensification and intensification of potential economic sources reduces regional governments' dependence on central government finance.
Keluwih (Artocarpus camansi) extract effects in zebrafish models of Parkinson’s disease
Authors: Gondokesumo Marisca Evalina , Budipramana Krisyanti , Putri Putu Dea Angelita , Nopitasari Ni Putu Diah , Aditya Martanty , Yusan Liza Yudistira 
Published: December 2023

Parkinson’s disease is a condition that affects the central nervous system in the brain and is brought on by a lack of dopamine. Uncontrollable tremors, uncoordinated movement, and stiffness characterize Parkinson’s disease. Until now, the medication for Parkinson’s disease is limited to relieve the symptoms and maintain the quality of life; thus, the progression of the disease can be delayed. In order to search for alternative therapy from herbs, Kluwih (Artocarpus camansi) has been used traditionally to relieve convulsants. This research aims to observe 96% ethanol extract of A. camansi leaves in dopamine and locomotor activity in adult male and female zebrafish (Dario rerio). The A. camansi extract concentration was 2.5; 5; 7.5; and 10 mg/ml for 28 days. Zebrafish locomotion was observed for 5 minutes on days 0; 7; 14; 21; and 28. ELISA measured the observations of dopamine after 28 days. The 96% ethanol extract of A. camansi leaves at 5 mg/ml can increase dopamine levels after induced with rotenone, but the dopamine level decreased at 7,5 and 10 mg/ml. The maximal concentration to increase locomotor activity is also at 5 mg/ml, along with dopamine concentration. Our findings revealed that 5 mg/ml of 96% ethanol extract of A. camansi leaves was the optimal dosage to stimulate dopamine release and enhance locomotor activity.
Coletânea Maranhense do Agronegócio e Agricultura Familiar - Volume 1
Authors: Nobre Camila Pinheiro , Pinheiro Eduardo Mendonça , Bosco Mousinho Reis João 
Published: December 2023

O primeiro volume da Coletânea Maranhense do Agronegócio e Agricultura Familiar é um produto fruto dos trabalhos apresentados durante a II Reunião Maranhense do Agronegócio e Agricultura Familiar, realizada entre os dias 17 e 18 de outubro de 2023, no campus UEMA em Itapecuru Mirim. O evento, assim como este volume foram fomentados através do edital eventos científicos (01112/23) da Fundação de Amparo à Pesquisa e Desenvolvimento Tecnológico do Estado do Maranhão – FAPEMA e possui dez capítulos abordando os seguintes temas: agricultura familiar, programa de aquisição de alimentos, cadeia produtiva de ovinos, qualidade de farinha de mandioca, cenário da agricultura maranhense em relação às mudanças climáticas, conforto térmico e alimentação animal, produção de soja, fruticultura e fruteiras nativas.
Representaciones sobre el cuerpo, prostitución y territorio a partir del transfemicidio de Pelusa Liendro (2006) en Salta
Authors: Guzmán González Diana 
Published: December 2023

En este artículo presentaremos los avances de investigación en torno a representaciones circulantes en los discursos registrados a partir del transfemicidio de Pelusa Liendro, referente y militante por los derechos de la comunidad LGTBIQ+, quien fue asesinada en el año 2006 en Salta. A partir de aportes procedentes de la Semiótica de la Cultura, Semiótica del Cuerpo y Estudios de Género, reflexionaremos sobre la Zona Roja, como territorio donde se ejerce públicamente la prostitución, y los significantes registrados en el expediente judicial que vinculan la identidad de género disidente con una dimensión patologizante.
El estudio del discurso nos introducirá, entre otros aspectos, en la comprensión de los modos de regulación de los cuerpos, las tensiones que se generaron en la constitución de su identidad durante la investigación policial y las condiciones de posibilidad que enmarcaron la consumación del crimen.
exposure of English Ordinary Level learners to reading by ESL teachers
Authors: Ithindi Sylvia Ndapewa , Engelbrecht Alta , De Jager Lizette 
Published: December 2023

This study investigates the exposure to reading of English Second Language (ESL) learners at Ordinary Level (OL) in Khomas region Senior Secondary Schools. The study focuses on how ESL teachers expose OL learners to reading in the classroom. The qualitative approach with a descriptive case study design was used for this study. Data were collected using non-participant classroom observation and semi-structured interviews with ESL teachers. The collected data were analysed by establishing themes and emerging categories. The study is informed by the principles of the multiliteracies pedagogy of the New London Group (NLG) (1999). The study established that ESL teachers were not exposing OL learners to reading sufficiently, because they were still entrapped in mono-modal teaching habits. The ESL teachers who participated in this study revealed that it was challenge to find appropriate reading materials to use in the classrooms. In addition, participants in this study also demonstrated the lack of broad conceptualisation of literacy that is aligned with the principles and components of the multiliteracies pedagogy. The premise of this paper is to suggest ways in which OL learners can be exposed effectively to reading in ESL classrooms. This study recommends that the principles of the multiliteracies pedagogy (overt instruction, situated practice, critical framing and transformed practices) ought to be introduced in ESL classrooms in Namibia. As a result, ESL teachers will be able to create learning experiences that enable learners to develop strategies to read in a new and unfamiliar manner.
New Awareness of the Interplay Between the Gut Microbiota and Circadian Rhythms
Authors: Pang Xiaoxiao , Chen Long , Xu Guoxin 
Published: December 2023

Abstract
Circadian rhythms influence various aspects of the biology and physiology of the host, such as food intake and sleep/wake cycles. In recent years, an increasing amount of genetic and epidemiological data has shown that the light/dark cycle is the main cue that regulates circadian rhythms. Other factors, including sleep/wake cycles and food intake, have necessary effects on the composition and rhythms of the gut microbiota. Interestingly, the gut microbiota can affect the circadian rhythm of hosts in turn through contact-dependent and contact-independent mechanisms. Furthermore, the gut microbiota has been shown to regulate the sleep/wake cycles through gut-brain-microbiota interaction. In addition to diabetes, the gut microbiota can also intervene in the progression of neuro- degenerative diseases through the gut-brain-microbiota interaction, and also in other diseases such as hypertension and rheumatoid arthritis, where it is thought to have a spare therapeutic potential. Even though fecal microbiota transplantation has good potential for treating many diseases, the risk of spreading intestinal pathogens should not be ignored.
The Influence of Work Commitment and Work Motivation on the Performance of Population and Civil Registration Service Employees in South Papua Province: The Mediating Role of Work Discipline
Authors: Totok Sudarmanto  , Meinarni Asnawi  , Sandra Sukmaning Adji  
Published: December 2023

This study delves into the intricate relationship between work commitment, work motivation, and employee performance, with work discipline serving as a mediating factor. Employing a quantitative research approach and causality analysis, a questionnaire was administered to all employees of the Population and Civil Registration Service in South Papua Province, encompassing Merauke, Boven Digoel, Mappi, and Asmat Regencies. Out of the 220 questionnaires distributed, 214 yielded valid responses suitable for data analysis. SEM-PLS analysis was utilized for hypothesis testing. The findings reveal a positive and significant influence of work commitment and work motivation on work discipline. Furthermore, work commitment, work motivation, and work discipline all demonstrate a positive impact on employee performance. Notably, work discipline effectively mediates the relationship between work commitment and work motivation on employee performance.
This study delves into the intricate relationship between work commitment, work motivation, and employee performance, with work discipline serving as a mediating factor. Employing a quantitative research approach and causality analysis, a questionnaire was administered to all employees of the Population and Civil Registration Service in South Papua Province, encompassing Merauke, Boven Digoel, Mappi, and Asmat Regencies. Out of the 220 questionnaires distributed, 214 yielded valid responses suitable for data analysis. SEM-PLS analysis was utilized for hypothesis testing. The findings reveal a positive and significant influence of work commitment and work motivation on work discipline. Furthermore, work commitment, work motivation, and work discipline all demonstrate a positive impact on employee performance. Notably, work discipline effectively mediates the relationship between work commitment and work motivation on employee performance.
Análisis de la importancia de las pymes en la economía del Ecuador
Authors: Saavedra Tenesaca José Antonio , Tenecela Espinoza Diego Armando , Araujo Ochoa Gabriela Isabel 
Published: December 2023

Introducción. La presente investigación analiza a las pequeñas y medianas empresas (Pymes) que son organizaciones con recursos limitados que operan en un lugar específico y de capital pequeño, pero con grandes virtudes como una gran flexibilidad para afrontar los cambios del mercado, además las pymes tienen una alta participación en la economía, debido a que promueve empleo y genera riqueza por lo que se ha notado que a lo largo del tiempo estas han tenido un crecimiento importante. Objetivo. el objetivo de la presente investigación es analizar la importancia de las pymes en la economía del Ecuador por medio de la revisión del estado del arte, diagnóstico de las diferentes bases de datos y determinar la correlación de las variables. Metodología. La investigación asumió una metodología no experimental, debido a que no se construirá una situación, sino que se observarán diferentes situaciones que han existido. Resultados. la mayoría de las empresas en el Ecuador pertenecen a organizaciones familiares, las pymes son una unidad económica dinamizadora de fuentes empleo y que estas por su tamaño se caracteriza por su rápida adaptación ante los cambios del entorno, sin embargo, estas se han visto detenidas por la falta de apoyo en la obtención de recursos financieros que permitiría mejorar sus estructuras y sobrevivir en el mercado a lo largo del tiempo. Conclusión. Las Pymes generan el 32.38% del total de empleo registrado aportando con 7.5 millones de dólares anules, apoyando grandemente a la economía del país, sin embargo, se debe pensar en que las fuentes de financiamiento es un grave problema que afecta la sostenibilidad de estas. Área de estudio general: Administración y Economía. Área de estudio específica: Estudio de PYMES.
Employer Branding Dalam Pelayanan Publik Bidang Kesehatan di Rsud Banten
Authors: Widyastuti Yeni , Rizkiyani Tiwi , Rahayu Sierfi 
Published: December 2023

Grand Design Reformasi Birokrasi di Indonesia berdasarkan Keputusan Presiden No.81/2010 bertujuan agar reformasi menjadi fokus dan berkelanjutan. Pencapaian strategis bahwa negara bebas dari korupsi, meningkatkan kapasitas dan akuntabilitas serta memperkuat orientasi terhadap peningkatan pelayanan publik. Kepentingan publik pada dasarnya adalah tujuan tertinggi bagi pemerintah. Peran pemerintah adalah memberikan pelayanan publik terbaik kepada masyarakat, pelayanan yang manusiawi, menempatkan pengguna jasa (masyarakat) sebagai pusat kepentingan, standar pelayanan yang profesional. Urgensi employer branding dalam pelayanan publik, khususnya pelayanan kesehatan, merupakan bagian dari mewujudkan kondisi ini.

Kata kunci : employer branding, sektor kesehatan
The prevalence and clustering of metabolic syndrome risk components in Chinese population: a cross-sectional study
Authors: Zhao Xu , Lu Cihang , Song Bo , Chen Deshi , Teng Di , Shan Zhongyan , Teng Weiping 
Published: December 2023

ObjectiveThe metabolic syndrome (MetS) is diagnosed upon the manifestation of ≥ 3 out of 5 specific components. The present study evaluated the epidemiological characteristics of the MetS components and their clustering condition among Chinese adults.Methods68383 participants aged 18-80 years from TIDE were scored on a six-point (0–5) MetS severity score (MSSS), which quantified their cumulative amount of MetS risk components. We evaluated the epidemiological characteristics of these components and their clustering conditions. Additionally, we examined the relation of age with the prevalence of different MSSSs or specific MetS components using restricted cubic splines.ResultsAmong 68383 participants, 26113 men and 24582 women had abnormal MetS components. There were significant differences in most epidemiological characteristics between the 6 MSSS groups. The top three prevalence of abnormal metabolic components were high systolic blood pressure (SBP) (9.41%, n=6568), high waist circumference (WC) (8.13%, n=6120), and the cooccurrence of high SBP and high WC (6.33%, n=4622). Participants were more likely to have all five MetS components when HDL-C was low. Restricted cubic splines showed that when the MSSS ≥3, the MetS prevalence of male peaked and that of the female population increased most rapidly at 40-60 age group.ConclusionThe 40-60 age group can be regarded as the high-risk period of MetS, and elderly women have a higher risk of multiple metabolic disorders than men. The top three clustering of abnormal metabolic components were high SBP, high WC, and their combination. Multiple components aggregation was more likely to occur when HDL-C decreased.
Comprehensive human health risk assessment of heavy metal contamination in urban soils: insights from selected metropolitan zones
Authors: Ayaz Harris , Nawaz Rab , Nasim Iqra , Irshad Muhammad Atif , Irfan Ali , Khurshid Iram , Okla Mohammad K. , Wondmie Gezahign Fentahun , Ahmed Zulkifl , Bourhia Mohammed 
Published: December 2023

Introduction: This study aims to assess the extent of heavy metal contamination in urban soils in sixteen selected cities of Pakistan, encompassing the elements cadmium (Cd), lead (Pb), cobalt (Co), zinc (Zn), chromium (Cr), nickel (Ni), manganese (Mn), iron (Fe), and copper (Cu).Methods: The data utilized for this study was collected from online literature during the period 2005 to 2019. This study investigated potential threats to human health through a comprehensive analysis, considering standards such as Enrichment Factors (EF), Geo-accumulation Indices (Igeo), and Human Health Risk Assessment (HHRA).Results: Geo-accumulation Index results indicated varied risk intensities, with Cu, Pb, Co, Mn, and Fe exhibiting “no pollution” levels, while other elements show “moderate to extremely contaminated” values. EF analysis provided evidence of heavy metal presence, revealing a spectrum from “no pollution” to “moderate to extremely high pollution” for Cd, Zn, Cr, Ni, and Cu. The health risk assessment identified both carcinogenic and non-carcinogenic dangers for adults and children.Discussion: These findings highlighted the substantial contribution of identified sources such as industrial processes, vehicular emissions, sewage sludge, urban flooding, and the production and use of metallic materials that have elevated heavy metal levels in the urban soils. This established the link between urban industrial zones, human health, and long-term economic sustainability. This study provides essential guidance for decision makers to develop effective strategies for soil remediation, enhanced industrial practices, and regulatory measures to address heavy metal contamination in urban areas, ensuring the wellbeing and sustainable environmental quality management in cities.
Should acupuncture become a complementary therapy in the treatment of uterine fibroid: a systematic review and meta-analysis of randomized controlled trials
Authors: Ren Yuehan , Zhang Junning , Wu Weizhen , Yuan Yi , Wang Jiale , Tang Yi , Liao Yan , Liu Xinmin 
Published: December 2023

BackgroundUterine fibroids (UFs) are the most common benign tumors in women of reproductive age. The most effective treatment is myomectomy, but there is no long-term or low-invasive treatment option exists. Acupuncture can be used to treat UFs in a variety of ways. However, there is no meta-analytic synthesis including valid data that explored the efficacy of acupuncture for UFs.ObjectiveTo assess the efficacy and safety of acupuncture for treating UFs.MethodsThe PRISMA 2020 checklist was used. We identified and extracted the trials through may 2023 from six databases. The quality of the trials was assessed using the risk of bias (2.0). Meta-analysis was performed using RevMan 5.4 software, and it was synthesized using the random-effects model if the included studies were in high heterogeneity. Subgroup and sensitivity analysis were used if necessary.ResultsA total of 1,035 trials were identified, of which 11 were included in the review and meta-analysis. In terms of acupuncture scheme design and fibroid-related symptoms, the trials are highly heterogeneous. All 11 trials have reported acupuncture types, with traditional acupuncture and electroacupuncture being the more representative subgroups. A qualitative review of existing evidence shows that acupuncture has no serious adverse reaction on UFs. Meta-analysis shows that acupuncture can effectively reduce the volume of UFs (MD – 3.89, 95% CI – 5.23 to – 2.56, P &lt; 0.00001) or uterine volume (MD – 16.22, 95% CI – 19.89 To – 12.55, p &lt; 0.00001), reduce the score of fibroid symptoms (MD – 3.03, 95% CI − 3.45 to – 2.60, p &lt; 0.00001), improve the treatment efficiency (RR: 0.19, 95% CI: 0.13 to 0.25, p &lt; 0.00001), and likely do not affect the estrogen level.
Biomarkers for predicting the severity of spinal cord injury by proteomic analysis
Authors: Wei Liangfeng , Huang Yubei , Chen Yehuang , Wu Jianwu , Chen Kaiqin , Zheng Zhaocong , Wang Shousen , Xue Liang 
Published: December 2023

PurposeCurrently, there is a shortage of the protein biomarkers for classifying spinal cord injury (SCI) severity. We attempted to explore the candidate biomarkers for predicting SCI severity.MethodsSCI rat models with mild, moderate, and severe injury were constructed with an electro-mechanic impactor. The behavior assessment and pathological examinations were conducted before and after SCI. Then, quantitative liquid chromatography-mass spectrometry (LC-MS/MS) was performed in spinal cord tissues with different extents of injury. The differentially expressed proteins (DEPs) in SCI relative to controls were identified, followed by Mfuzz clustering, function enrichment analysis, and protein-protein interaction (PPI) network construction. The differential changes of candidate proteins were validated by using a parallel reaction monitoring (PRM) assay.ResultsAfter SCI modeling, the motor function and mechanical pain sensitivity of SCI rats were impaired, dependent on the severity of the injury. A total of 154 DEPs overlapped in the mild, moderate, and severe SCI groups, among which 82 proteins were classified in clusters 1, 2, 3, 5, and 6 with similar expression patterns at different extents of injury. DEPs were closely related to inflammatory response and significantly enriched in the IL-17 signaling pathway. PPI network showed that Fgg (Fibrinogen gamma chain), Fga (Fibrinogen alpha chain), Serpinc1 (Antithrombin-III), and Fgb (Fibrinogen beta chain) in cluster 1 were significant nodes with the largest degrees. The upregulation of the significant nodes in SCI samples was validated by PRM.ConclusionFgg, Fga, and Fgb may be the putative biomarkers for assessing the extent of SCI.
Effectiveness and safety of standard chemotherapy in older patients with ovarian cancer: a retrospective analysis by age group and treatment regimen
Authors: Brezis Miriam R. , Shachar Eliya , Peleg Hasson Shira , Laskov Ido , Michaan Nadav , Levy Bar , Wolf Ido , Safra Tamar 
Published: December 2023

ObjectiveTo evaluate the effectiveness and safety of standard chemotherapy administered to patients &gt;70 years with advanced ovarian cancer (OC).MethodsMedical records of 956 advanced-stage patients with OC treated between 2002-2020 with standard surgery and paclitaxel-carboplatin chemotherapy in a three-weekly (PC-3W) or weekly (PC-1W) regimen were reviewed. Treatment response and tolerability were compared between patients ≤70 years (N=723) and &gt;70 years (N=233) with stratification to septuagenarians (&gt;70-80 years) and octogenarians (&gt;80 years).ResultsMedian overall survival (mOS) in patients &gt;70 was 41.26 months (95% confidence interval [Cl], 37.22-45.14) and median progression-free survival (mPFS) was 11.04 months (95% Cl, 8.97-15.74). No statistically significant differences in mPFS and mOS were observed between septuagenarians and octogenarians. Patients &gt;70 treated with PC-1W versus PC-3W had significantly longer mOS (57.17 versus 30.00 months) and mPFS (19.09 versus 8.15 months). Toxicity rates were mostly similar between younger and older patients. Among patients &gt;70 treated with PC-1W, the rate of neutropenia (75.7% versus 51.8%, p=0.0005), thrombocytopenia (41.0% versus 22.2%, p=0.0042) and anemia (78.1% versus 51.9%, p&lt;0.0001) were significantly higher and the rate of grade 2 alopecia was statistically significantly lower compared with those &gt;70 treated with PC-3W. Significantly more patients treated with PC-1W completed ≥6 chemotherapy cycles, suggesting better tolerability of this regimen.ConclusionsOlder patients with OC may benefit from improved OS with reasonable toxicity if treated with standard chemotherapy. Older patients treated with PC-1W are more likely to complete the full chemotherapy course and survive longer compared with those treated with conventional PC-3W.