bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnose- und Aufnahmezentrum
Authors: Braun Urs , Hennig Oliver , Forstner Johanna , Gerhardt Sarah , Deffaa Mirjam ,   DAZ-Team (die Mitglieder sind am Beitragsende aufgelistet), Hirjak Dusan , Deuschle Michael , Koopmann Anne , Wisch Christian , Fritz Melanie , Ende Gabriele , Tost Heike , Schöfer Peter , Bischoff Stefan , Janta Matthias , Kiefer Falk , Schmahl Christian , Banaschewski Tobias , Meyer-Lindenberg Andreas 
Published: February 2024

ZusammenfassungDie routinemäßige, tiefgreifende Charakterisierung von Patienten mit Methoden der klinischen und skalenbasierten Untersuchung, der Neuropsychologie, anhand von Biomaterialien und sensorbasierten Informationen verspricht transformative Möglichkeiten auf dem Weg zu einer personalisierten Diagnostik, Therapie und Prävention in der Psychiatrie, Psychotherapie und Psychosomatik. Die effektive Integration des zusätzlichen zeitlichen und logistischen Aufwands in den Versorgungsalltag sowie die Akzeptanz bei Patienten sind entscheidend für den Erfolg eines solchen Ansatzes, hierzu liegen jedoch bisher kaum Daten vor. Wir berichten hier über die Etablierung eines Diagnose- und Aufnahmezentrums (DAZ) am Zentralinstitut für Seelische Gesundheit (ZI) in Mannheim. Beim DAZ handelt es sich um eine den anderen Versorgungstrukturen vorgeschaltete ambulante Einheit zur klinischen und wissenschaftlichen diagnoseübergreifenden Phänotypisierung als Ausgangsbasis für eine datenunterstützte, individuelle Bahnung der weiteren Behandlungs‑, Diagnostik- oder Studienpfade. Wir beschreiben die Funktionen, Ziele und Implementierung der neu geschaffenen klinisch-wissenschaftlich translationalen Struktur, geben einen Überblick über die damit erreichten Patientenpopulationen und liefern Daten zur Akzeptanz. Die enge Verzahnung mit den nachgelagerten klinischen Prozessen ermöglicht dabei eine besser abgestimmte und bedarfsorientierte Zuweisung und einen schnelleren Beginn der störungsspezifischen Diagnostik und Therapie. Seit dem Start im April 2021 bis Ende 2022 wurden in einer Pilotphase 1021 Patienten im DAZ psychiatrisch untersucht. Die Patientenklientel entsprach dabei einer repräsentativen Stichprobe aus der Regelversorgung und die neu etablierten Prozesse wurden von Patienten als hilfreich erlebt. Zusammenfassend verknüpft das DAZ somit in hohem Maße Interessen und Bedürfnisse der Patienten mit der Erhebung wissenschaftlich relevanter Daten.
Quality enhancement of micro-milled channels with automated laser assistance
Authors: Sahu Ashish Kumar , Iqbal Faiz , Jha Sunil 
Published: February 2024

Abstract
Microchannels are utilised on material surfaces of a body, allowing coolant to pass through them and enabling heat dissipation by increased contact area. Fabrication of metal surface microchannels is primarily achieved by employing a micro-milling process, which has drawbacks such as excessive cutting forces, top burrs, tool wear, and lower tool life. Alternatively, it is also realised by using Laser micro milling, which has problems associated with lower quality of surface finish, un-desired taper, heat-affected zone, and spatters. The existing literature, after due review of the current state of the art, has brought out gaps needing attention. These gaps are limited capability to reduce surface roughness, unaddressed burr width, and irregular bottom surface morphology, which affect microchannel quality. These gaps motivate this research work to improve and sustain the microchannel quality. To achieve the goals, this research work performs the fabrication of microchannels by micro-milling with automated laser assistance being achieved in two ways (a) sequentially, (b) non-sequentially, termed as LASMM and LPCMM, which are novel for the scientific community. The effects of micro milling parameters, spindle speed and feed on the quality were analysed while machining commercially pure titanium (cp-Ti). Results show that laser assistance to micro-milling provides a lower generation of undesired forces and lesser top burrs compared to micro-milling alone. In sequential laser assistance, the channels have a mean down burr width ~ 58% lower and a maximum down burr width ~ 38% lower than the channels done non-sequentially. In the case of up-burr width, a mean value ~ 60% lower and a maximum value ~ 73% lower is achieved in channels done non-sequentially as compared to those done sequentially. In the case of surface roughness, channels done sequentially have a maximum Sa value of 1.508 µm, a maximum Sq value of 1.912 µm whereas non-sequentially, they show a maximum Sa value of 3.495 µm, maximum Sq value of 4.59 µm. Steady tool wear is observed sequentially, whereas in non-sequential, rapid tool wear occurs after 500 mm of cutting length.
Bayesian composite $$L^p$$-quantile regression
Authors: Arnroth Lukas 
Published: February 2024

Abstract

$$L^p$$

L
p

-quantiles are a class of generalized quantiles defined as minimizers of an asymmetric power function. They include both quantiles,

$$p=1$$

p
=
1

, and expectiles,

$$p=2$$

p
=
2

, as special cases. This paper studies composite

$$L^p$$

L
p

-quantile regression, simultaneously extending single

$$L^p$$

L
p

-quantile regression and composite quantile regression. A Bayesian approach is considered, where a novel parameterization of the skewed exponential power distribution is utilized. Further, a Laplace prior on the regression coefficients allows for variable selection. Through a Monte Carlo study and applications to empirical data, the proposed method is shown to outperform Bayesian composite quantile regression in most aspects.
Distances and angles in standing long-leg radiographs: comparing conventional radiography, digital radiography, and EOS
Authors: Birkenmaier Christof , Levrard Louise , Melcher Carolin , Wegener Bernd , Ricke Jens , Holzapfel Boris M. , Baur-Melnyk Andrea , Mehrens Dirk 
Published: February 2024

Abstract
Objective
Distances and angles measured from long-leg radiographs (LLR) are important for surgical decision-making. However, projectional radiography suffers from distortion, potentially generating differences between measurement and true anatomical dimension. These phenomena are not uniform between conventional radiography (CR) digital radiography (DR) and fan-beam technology (EOS). We aimed to identify differences between these modalities in an experimental setup.

Materials and methods
A hemiskeleton was stabilized using an external fixator in neutral, valgus and varus knee alignment. Ten images were acquired for each alignment and each modality: one CR setup, two different DR systems, and an EOS. A total of 1680 measurements were acquired and analyzed.

Results
We observed great differences for dimensions and angles between the 4 modalities. Femoral head diameter measurements varied in the range of > 5 mm depending on the modality, with EOS being the closest to the true anatomical dimension. With functional leg length, a difference of 8.7% was observed between CR and EOS and with the EOS system being precise in the vertical dimension on physical-technical grounds, this demonstrates significant projectional magnification with CR-LLR. The horizontal distance between the medial malleoli varied by 20 mm between CR and DR, equating to 21% of the mean.

Conclusions
Projectional distortion resulting in variations approaching 21% of the mean indicate, that our confidence on measurements from standing LLR may not be justified. It appears likely that among the tested equipment, EOS-generated images are closest to the true anatomical situation most of the time.
Managing hardware-related metal artifacts in MRI: current and evolving techniques
Authors: Feuerriegel Georg C. , Sutter Reto 
Published: February 2024

AbstractMagnetic resonance imaging (MRI) around metal implants has been challenging due to magnetic susceptibility differences between metal implants and adjacent tissues, resulting in image signal loss, geometric distortion, and loss of fat suppression. These artifacts can compromise the diagnostic accuracy and the evaluation of surrounding anatomical structures. As the prevalence of total joint replacements continues to increase in our aging society, there is a need for proper radiological assessment of tissues around metal implants to aid clinical decision-making in the management of post-operative complaints and complications. Various techniques for reducing metal artifacts in musculoskeletal imaging have been explored in recent years. One approach focuses on improving hardware components. High-density multi-channel radiofrequency (RF) coils, parallel imaging techniques, and gradient warping correction enable signal enhancement, image acquisition acceleration, and geometric distortion minimization. In addition, the use of susceptibility-matched implants and low-field MRI helps to reduce magnetic susceptibility differences. The second approach focuses on metal artifact reduction sequences such as view-angle tilting (VAT) and slice-encoding for metal artifact correction (SEMAC). Iterative reconstruction algorithms, deep learning approaches, and post-processing techniques are used to estimate and correct artifact-related errors in reconstructed images. This article reviews recent developments in clinically applicable metal artifact reduction techniques as well as advances in MR hardware. The review provides a better understanding of the basic principles and techniques, as well as an awareness of their limitations, allowing for a more reasoned application of these methods in clinical settings.
Angewandte Improvisation in der Psychotherapie
Authors: Stein Miriam , Dshemuchadse Maja , Scherbaum Stefan , Schnell Knut 
Published: February 2024

ZusammenfassungDer Beitrag beschreibt, wie die Angewandte Improvisation im Rahmen von Psychotherapie nutzbar ist, um grundlegende therapeutische Modelle der sozialen Interaktion leichter verständlich und im Alltag praktisch anwendbar zu machen. Die Angewandte Improvisation bietet für die Psychotherapie im Sinne der interaktionellen Achtsamkeit eine Haltung und ein großes Repertoire von Übungen, mit denen sich die bewusste und flexible Gestaltung von Beziehungen spielerisch trainieren lässt. Die wesentlichen Prinzipien der Angewandten Improvisation werden vorgestellt, um darauf aufbauend darzulegen, wie die Angewandte Improvisation konkret im Kontext der Psychotherapie sinnvoll zum Einsatz kommen kann. Prinzipien und Übungen aus dem Improvisationstheater werden mit Grundkonzepten der Psychotherapie verknüpft. Der Beitrag gibt insbesondere einen Überblick über empirisch belegte Modelle sozialer Interaktion entlang der Konsistenztheorie, des Circumplexmodells und des Rupture-Repair-Ansatzes.
Integrated transcriptome and metabolome analysis revealed that HaMYB1 modulates anthocyanin accumulation to deepen sunflower flower color
Authors: Ma Siqi , Zhou Hanlin , Ren Tingting , Yu Er-ru , Feng Bin , Wang Juying , Zhang Chengsheng , Zhou Chao , Li Yiqiang 
Published: February 2024

Abstract
Key message
HanMYB1 was found to play positive roles in the modulation of anthocyanins metabolism based on the integrative analysis of different color cultivars and the related molecular genetic analyses.

Abstract
As a high value ornamental and edible crop with various colors, sunflowers (Helianthus annuus L.) provide an ideal system to understand the formation of flower color. Anthocyanins are major pigments in higher plants, which is associated with development of flower colors and ability of oxidation resistance. Here, we performed an integrative analysis of the transcriptome and flavonoid metabolome in five sunflower cultivars with different flower colors. According to differentially expressed genes and differentially accumulated flavonoids, these cultivars could be grouped into yellow and red. The results showed that more anthocyanins were accumulated in the red group flowers, especially the chrysanthemin. Some anthocyanins biosynthesis-related genes like UFGT (UDP-glycose flavonoid glycosyltransferase) also expressed more in the red group flowers. A MYB transcriptional factor, HanMYB1, was found to play vital positive roles in the modulation of anthocyanins metabolism by the integrative analysis. Overexpressed HanMYB1 in tobacco could deepen the flower color, increase the accumulation of anthocyanins and directly active the express of UFGT genes. Our findings indicated that the MYB transcriptional factors provide new insight into the dynamic regulation of the anthocyanin biosynthesis in facilitating sunflower color formation and anthocyanin accumulation.
RFC1 repeat expansions in downbeat nystagmus syndromes: frequency and phenotypic profile
Authors: Pellerin David , Heindl Felix , Traschütz Andreas , Rujescu Dan , Hartmann Annette M. , Brais Bernard , Houlden Henry , Dufke Claudia , Riess Olaf , Haack Tobias , Strupp Michael , Synofzik Matthis 
Published: February 2024

Abstract
Objectives
The cause of downbeat nystagmus (DBN) remains unknown in a substantial number of patients (“idiopathic”), although intronic GAA expansions in FGF14 have recently been shown to account for almost 50% of yet idiopathic cases. Here, we hypothesized that biallelic RFC1 expansions may also represent a recurrent cause of DBN syndrome.

Methods
We genotyped the RFC1 repeat and performed in-depth phenotyping in 203 patients with DBN, including 65 patients with idiopathic DBN, 102 patients carrying an FGF14 GAA expansion, and 36 patients with presumed secondary DBN.

Results
Biallelic RFC1 AAGGG expansions were identified in 15/65 patients with idiopathic DBN (23%). None of the 102 GAA-FGF14-positive patients, but 2/36 (6%) of patients with presumed secondary DBN carried biallelic RFC1 expansions. The DBN syndrome in RFC1-positive patients was characterized by additional cerebellar impairment in 100% (15/15), bilateral vestibulopathy (BVP) in 100% (15/15), and polyneuropathy in 80% (12/15) of cases. Compared to GAA-FGF14-positive and genetically unexplained patients, RFC1-positive patients had significantly more frequent neuropathic features on examination and BVP. Furthermore, vestibular function, as measured by the video head impulse test, was significantly more impaired in RFC1-positive patients.

Discussion
Biallelic RFC1 expansions are a common monogenic cause of DBN syndrome.
Chidamide and orelabrutinib synergistically induce cell cycle arrest and apoptosis in diffuse large B-cell lymphoma by regulating the PI3K/AKT/mTOR pathway
Authors: Wu Chunyan , Chen Shilv , Wu Zhimin , Xue Jiao , Zhang Wen , Wang Shan , Xindong Zhao  , Wu Shaoling 
Published: February 2024

Abstract
Objective
The initial therapeutic approach for diffuse large B-cell lymphoma (DLBCL) entails a rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen. However, 40% of patients exhibit suboptimal responses, with some experiencing relapse and refractory conditions. This study aimed to explore novel therapeutic strategies and elucidate their underlying mechanisms in DLBCL.

Methods
Bioinformatics techniques were employed to scrutinize correlations between the HDAC1, HDAC2, HDAC3, HDAC10, BTK, MYC, TP53, and BCL2 genes in DLBCL. In vitro experiments were conducted using DB and SU-DHL-4 cells treated with chidamide, orelabrutinib, and a combination of both. Cell viability was assessed by cell counting kit-8. Cell apoptosis and the cell cycle were determined using flow cytometry. Reactive oxygen species (ROS) production and mitochondrial function were assessed through ROS and JC-1 staining. RNA sequencing and western blot analyses were conducted to elucidate the molecular mechanisms underlying the combined action of chidamide and orelabrutinib in DLBCL cells.

Results
This investigation revealed markedly enhanced antiproliferative effects when chidamide was combined with orelabrutinib. Compusyn software analysis indicated a synergistic effect of chidamide and orelabrutinib in inhibiting DLBCL cell proliferation, with a combination index (CI) < 1. This synergy further manifested as augmented cell cycle arrest, apoptosis induction, the downregulation of cell cycle-associated and antiapoptotic proteins, and the upregulation of proapoptotic proteins. Furthermore, the western blot and RNA-Seq findings suggested that combining chidamide and orelabrutinib modulated the PI3K/AKT/mTOR signaling pathway, thereby promoting DLBCL cell cycle arrest and apoptosis.

Conclusion
The findings of this study provide a compelling justification for the clinical utilization of chidamide and orelabrutinib to treat relapsed/refractory DLBCL.
Causal relationship between psychological factors and hepatocellular carcinoma as revealed by Mendelian randomization
Authors: Xu Fengming , Dirsch Olaf , Dahmen Uta 
Published: February 2024

Abstract
Purpose
The impact of psychological factors on the incidence of hepatocellular carcinoma (HCC) in humans remains unclear. Mendelian randomization (MR) study is a novel approach aimed at unbiased detection of causal effects. Therefore, we conducted a two-sample MR to determine if there is a causal relationship between psychological distress (PD), participation in leisure/social activities of religious groups (LARG), and HCC.

Methods
The genetic summary data of exposures and outcome were retrieved from genome-wide association studies (GWAS). We used PD and LARG as exposures and HCC as outcome. Five MR methods were used to investigate the causal relationship between PD, LARG, and HCC. The result of inverse variance weighted (IVW) method was deemed as principal result. Besides, we performed a comprehensive sensitivity analysis to verify the robustness of the results.

Results
The IVW results showed that PD [odds ratio (OR) 1.006, 95% confidence interval (CI) 1.000–1.011, P = 0.033] and LARG (OR 0.994, 95% CI 0.988–1.000, P = 0.035) were causally associated with the incidence of HCC. Sensitivity analysis did not identify any bias in the results.

Conclusion
PD turned out to be a mild risk factor for HCC. In contrast, LARG is a protective factor for HCC. Therefore, it is highly recommended that people with PD are seeking positive leisure activities such as participation in formal religious social activities, which may help them reduce the risk of HCC.

Graphical abstract
Immunophenotyping of peripheral blood in NSCLC patients discriminates responders to immune checkpoint inhibitors
Authors: Krizova Ludmila , Benesova Iva , Zemanova Petra , Spacek Jan , Strizova Zuzana , Humlova Zuzana , Mikulova Veronika , Petruzelka Lubos , Vocka Michal 
Published: February 2024

Abstract
Purpose
Immune checkpoint inhibitors (ICIs) dramatically changed the prognosis of patients with NSCLC. Unfortunately, a reliable predictive biomarker is still missing. Commonly used biomarkers, such as PD-L1, MSI, or TMB, are not quite accurate in predicting ICI efficacy.

Methods
In this prospective observational cohort study, we investigated the predictive role of erythrocytes, thrombocytes, innate and adaptive immune cells, complement proteins (C3, C4), and cytokines from peripheral blood of 224 patients with stage III/IV NSCLC treated with ICI alone (pembrolizumab, nivolumab, and atezolizumab) or in combination (nivolumab + ipilimumab) with chemotherapy. These values were analyzed for associations with the response to the treatment and survival endpoints.

Results
Higher baseline Tregs, MPV, hemoglobin, and lower monocyte levels were associated with favorable PFS and OS. Moreover, increased baseline basophils and lower levels of C3 predicted significantly improved PFS. The levels of the baseline immature granulocytes, C3, and monocytes were significantly associated with the occurrence of partial regression at the first restaging. Multiple studied parameters (n = 9) were related to PFS benefit at the time of first restaging as compared to baseline values. In addition, PFS nonbenefit group showed a decrease in lymphocyte count after three months of therapy. The OS benefit was associated with higher levels of lymphocytes, erythrocytes, hemoglobin, MCV, and MPV, and a lower value of NLR after three months of treatment.

Conclusion
Our work suggests that parameters from peripheral venous blood may be potential biomarkers in NSCLC patients on ICI. The baseline values of Tregs, C3, monocytes, and MPV are especially recommended for further investigation.
Evaluation of Mixing Effects and Particle Breakage on a Cross Flow Turbine with DEM
Authors: Denzel Michael , Prenner Michael , Sifferlinger Nikolaus A. 
Published: February 2024

AbstractVarious effects during conveying and storage processes lead to size segregation of bulk material, but many applications require a mostly constant particle size distribution. Especially during bunker filling, segregation effects are noticed, which are further intensified by possible core flow effects. In order to reduce segregation effects during bunker filling, a cross flow turbine is installed at a bunker used for storage of blast furnace sinter. In this contribution, discrete element simulations were performed to analyze mixing effects and possible particle breakage due to the cross flow turbine. Significant mixing effects during bunker filling are noticed due to the cross flow turbine. The results show a more evenly distributed bunker outflow in terms of particle size.Particle breakage is analyzed by means of a newly developed breakage model for the Discrete Element Method (DEM). The model is based on a probabilistic particle replacement with voronoi-tessellated fragments. The validated breakage model allows high accuracy in prediction of fragment size distribution. Fragments are further breakable, which allows simulation of processes with several damaging effects. The breakage model was calibrated with a specially developed automated single particle impact tester for rapid analysis of breakage characteristics of bulk materials.
Factorial design-assisted spectrophotometric methods for the determination of total catechins in green tea extract via reaction with MBTH. Application to commercial tablet
Authors: Salem Yara N. , Sharaf El-Din Mohie K. , Sheribah Zeinab A. , Fathy Mona E. 
Published: February 2024

AbstractGreen tea extract (GTE) is a supplement derived from the green tea plant which aids in weight loss along with other innumerable health. New analytical methods for determining GTE via its catechins using a design-assisted spectrophotometric methodologies are provided. The procedures are based on the formation of orange-colored products that are detectable at 473 or 455 nm, respectively, when catechins react with MBTH in the presence of FeCl3 (method I) or K2S2O8 (method II). Critical parameters were optimized using design of experiments (DOE). The absorbance-concentration plots were rectilinear over the ranges 4.0–20.0 or 4.0–40.0 µg cm−3 with limits of detection 0.393 or 0.493 µg cm−3 for methods I & II, respectively. Our methods were applied to pure catechins in GTE, namely (-)-epicatechin and (-)-epigallocatechin gallate. Moreover, the proposed methods were perfectly applied to the analysis of GTE in a commercial tablet. Good agreement between the collected data and those of the reported approach demonstrating that there were no significant variations. According to International Council for Harmonization (ICH) Guidelines, the procedures were validated.
Graphical abstract