bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spinal afferent innervation in flat-mounts of the rat stomach: anterograde tracing
Authors: Ma Jichao , Nguyen Duyen , Madas Jazune , Kwiat Andrew M. , Toledo Zulema , Bizanti Ariege , Kogut Nicole , Mistareehi Anas , Bendowski Kohlton , Zhang Yuanyuan , Chen Jin , Li De-Pei , Powley Terry L. , Furness John B. , Cheng Zixi 
Published: October 2023

AbstractThe dorsal root ganglia (DRG) project spinal afferent axons to the stomach. However, the distribution and morphology of spinal afferent axons in the stomach have not been well characterized. In this study, we used a combination of state-of-the-art techniques, including anterograde tracer injection into the left DRG T7-T11, avidin–biotin and Cuprolinic Blue labeling, Zeiss M2 Imager, and Neurolucida to characterize spinal afferent axons in flat-mounts of the whole rat stomach muscular wall. We found that spinal afferent axons innervated all regions with a variety of distinct terminal structures innervating different gastric targets: (1) The ganglionic type: some axons formed varicose contacts with individual neurons within myenteric ganglia. (2) The muscle type: most axons ran in parallel with the longitudinal and circular muscles and expressed spherical varicosities. Complex terminal structures were observed within the circular muscle layer. (3) The ganglia-muscle mixed type: some individual varicose axons innervated both myenteric neurons and the circular muscle, exhibiting polymorphic terminal structures. (4) The vascular type: individual varicose axons ran along the blood vessels and occasionally traversed the vessel wall. This work provides a foundation for future topographical anatomical and functional mapping of spinal afferent axon innervation of the stomach under normal and pathophysiological conditions.
Concurrent and lagged physiological synchrony during mother–child interaction and their relationship to positive affect in 8- to 10-year-old children
Authors: Capraz Yasemin Zehra , Konrad Kerstin , Reindl Vanessa 
Published: October 2023

AbstractMother–child interaction has been characterized by a fine-tuning of behavior and physiological activity. Yet, little is known about the dynamics of mother–child physiological synchrony during early school age and their associations to positive affect. To investigate these processes, 42 mother–child dyads, with children aged 8 to 10 years, played an interactive game while their interbeat intervals (IBI) and respiratory sinus arrhythmia (RSA) were measured simultaneously. IBI/RSA synchrony was calculated using cross-correlations of the IBI/RSA second-by-second time series for lags − 3 to + 3 seconds. Mother’s and child’s individual and shared positive affect were microcoded. During the interactive tasks, IBI and RSA synchrony significantly increased compared to control conditions. RSA and affect synchrony were significantly stronger for negative compared to positive lags indicating a stronger child leads/mother follows covariation. Further, dyad’s IBI and RSA synchrony were significantly associated to mother’s and child’s individual positive affect. Our data suggest that in low-risk community samples, mothers may respond to their children’s positive affect by matching their own affect and physiology. Investigating these temporally precise, concurrent and lagged synchrony processes may open up new avenues for understanding the ways in which parent–child interactions contribute to child developmental outcomes.
A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System
Authors: Beresniak Ariel , Russo Michele , Forte Gianpiero , Laganà Antonio Simone , Oliva Mario Montanino , Aragona Cesare , Chiantera Vito , Unfer Vittorio 
Published: October 2023

AbstractAccumulating evidence suggests that oral supplementation with myo-Inositol (myo-Ins) is able to reduce the amount of gonadotropins and days of controlled ovarian hyperstimulation (COS) necessary to achieve adequate oocyte maturation in assisted reproduction technology (ART) protocols, particularly in women affected by polycystic ovary syndrome (PCOS). We used computational calculations based on simulation modellings. We simulated in vitro fertilization (IVF) procedures—with or without intracytoplasmic sperm injection (ICSI)—with 100,000 virtual patients, accounting for all the stages of the entire IVF procedure. A Monte Carlo technique was used to account for data uncertainty and to generate the outcome distribution at each stage. We considered virtual patients with PCOS undergoing IVF cycles to achieve pregnancy. Computational data were retrieved from clinical experience and published data. We investigated three parameters related to ART protocols: cost of single procedure; efficacy to achieve ongoing pregnancy at 12 gestational weeks; overall cost per single pregnancy. The administration of oral myo-Ins during COH protocols, compared to the standard COH with recombinant Follicle Stimulating Hormone (rFSH) only, may be considered a potential strategy to reduce costs of ART for the Italian Health System.
Goodness-of-fit testing for meta-analysis of rare binary events
Authors: Zhang Ming , Xiao Olivia Y. , Lim Johan , Wang Xinlei 
Published: October 2023

AbstractRandom-effects (RE) meta-analysis is a crucial approach for combining results from multiple independent studies that exhibit heterogeneity. Recently, two frequentist goodness-of-fit (GOF) tests were proposed to assess the fit of RE model. However, they tend to perform poorly when assessing rare binary events. Under a general binomial-normal framework, we propose a novel GOF test for the meta-analysis of rare events. Our method is based on pivotal quantities that play an important role in Bayesian model assessment. It further adopts the Cauchy combination idea proposed in a 2019 JASA paper, to combine dependent p-values computed using posterior samples from Markov Chain Monte Carlo. The advantages of our method include clear conception and interpretation, incorporation of all data including double zeros without the need for artificial correction, well-controlled Type I error, and generally improved ability in detecting model misfits compared to previous GOF methods. We illustrate the proposed method via simulation and three real data applications.
Variational quantum metrology for multiparameter estimation under dephasing noise
Authors: Le Trung Kien , Nguyen Hung Q. , Ho Le Bin 
Published: October 2023

AbstractWe present a hybrid quantum-classical variational scheme to enhance precision in quantum metrology. In the scheme, both the initial state and the measurement basis in the quantum part are parameterized and optimized via the classical part. It enables the maximization of information gained about the measured quantity. We discuss specific applications to 3D magnetic field sensing under several dephasing noise models. Indeed, we demonstrate its ability to simultaneously estimate all parameters and surpass the standard quantum limit, making it a powerful tool for metrological applications.
Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver
Authors: Salameh Mariam , Zeitoun-Ghandour Sukaina , Sabra Lina , Daher Ahmad , Khalil Mahmoud , Joumaa Wissam H. 
Published: October 2023

AbstractThe current study investigated the effects of 24 h/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during their fetal development period. Fifty-two Sprague–Dawley pregnant rats were equally divided into control and exposed groups. Whole embryos were removed at 7.5 dpc (days post coitus), while liver tissues were extracted from embryos at 11.5, 15.5, and 19.5 dpc. For exposed animals, results showed an increased OS reflected by high levels of malondialdehyde (MDA), a decrease in cytosolic superoxide dismutase (cytoSOD) activity, in mitochondrial superoxide dismutase (mitoSOD) levels and catalase (CAT) mRNA expression but also in hepatic nuclear factor erythroïd 2-related Factor 2 (Nrf-2), protein kinase B (Akt1), and intercellular adhesion molecule-1 (ICAM-1) mRNA expression at 15.5 dpc. Moreover, GSM-EMR exposure was shown to significantly decrease mitoSOD and CAT activities at almost all studied ages. Thus, rat embryos may be protected by their mothers from OS, apoptotic, and pro-inflammatory responses till a sensitive developmental stage, during a continuous prenatal EMR exposure. This protection could be then created from the embryos themselves.
Analysis of a non-integer order mathematical model for double strains of dengue and COVID-19 co-circulation using an efficient finite-difference method
Authors: Obiajulu Emeka F. , Omame Andrew , Inyama Simeon C. , Diala Uchenna H. , AlQahtani Salman A. , Al-Rakhami Mabrook S. , Alawwad Abdulaziz M. , Alotaibi Abdullilah A. 
Published: October 2023

AbstractAn efficient finite difference approach is adopted to analyze the solution of a novel fractional-order mathematical model to control the co-circulation of double strains of dengue and COVID-19. The model is primarily built on a non-integer Caputo fractional derivative. The famous fixed-point theorem developed by Banach is employed to ensure that the solution of the formulated model exists and is ultimately unique. The model is examined for stability around the infection-free equilibrium point analysis, and it was observed that it is stable (asymptotically) when the maximum reproduction number is strictly below unity. Furthermore, global stability analysis of the disease-present equilibrium is conducted via the direct Lyapunov method. The non-standard finite difference (NSFD) approach is adopted to solve the formulated model. Furthermore, numerical experiments on the model reveal that the trajectories of the infected compartments converge to the disease-present equilibrium when the basic reproduction number ($${\mathbb {R}}_0$$

R
0

) is greater than one and disease-free equilibrium when the basic reproduction number is less than one respectively. This convergence is independent of the fractional orders and assumed initial conditions. The paper equally emphasized the outcome of altering the fractional orders, infection and recovery rates on the disease patterns. Similarly, we also remarked the importance of some key control measures to curtail the co-spread of double strains of dengue and COVID-19.
Serious infection risk of tofacitinib compared to biologics in patients with rheumatoid arthritis treated in routine clinical care
Authors: Riek Myriam , Scherer Almut , Möller Burkhard , Ciurea Adrian , von Mühlenen Ines , Gabay Cem , Kyburz Diego , Brulhart Laure , von Kempis Johannes , Mueller Ruediger B. , Hasler Paul , Strahm Tanja , von Känel Sabine , Zufferey Pascal , Dudler Jean , Finckh Axel 
Published: October 2023

AbstractRecently, serious infections related to the use of tofacitinib (TOF) for treatment of rheumatoid arthritis (RA) have raised considerable interest. This study aimed to compare the risk for serious infections in patients with RA upon receiving TOF versus biologic disease-modifying antirheumatic drugs (bDMARDs) by age at treatment initiation. We identified adult RA patients exposed to TOF or bDMARDs using data collected by the Swiss registry for inflammatory rheumatic diseases (SCQM) from 2015 to 2018. The event of interest was the first non-fatal serious infection (SI) during drug exposure. Missing or incomplete SI dates were imputed as either the lower (left) or upper (right) limit of the known occurrence interval. The ratio of SI hazards (HR) of TOF versus bDMARDs was estimated as a function of age using covariate-adjusted Cox regression applied to each type of imputed time-to-SI. A total of 1687 patients provided time at risk for a first SI during study participation and drug exposure for 2238 different treatment courses, 345 for TOF and 1893 for bDMARDs. We identified 44 (left imputation) or 43 (right imputation), respectively, first SIs (12/12 on TOF versus 32/31 on bDMARDs). Left and right imputation produced similar results. For patients aged ≥ 69 years, the treatment HR started to be increased (lower limit of 95% confidence intervals (LLCIs) > 1). By the age of 76, the difference between TOF and bDMARDs started to be clinically relevant (LLCIs > 1.25). For patients aged < 65 years, the data were insufficient to draw conclusions. Our results suggest that we should expect an increased risk for SIs in older patients treated with TOF compared to bDMARDs supporting a cautious use of TOF in these patients.
The impact of the anthropause caused by the COVID-19 pandemic on beach debris accumulation in Maui, Hawaiʻi
Authors: Currie Jens J. , Sullivan Florence A. , Beato Elizabeth , Machernis Abigail F. , Olson Grace L. , Stack Stephanie H. 
Published: October 2023

AbstractThe COVID-19 pandemic and subsequent travel restrictions led to a considerable reduction in tourism and human activity on Maui, presenting a unique opportunity to study debris accumulation on local beaches during changing levels of human activities. Standardized daily debris accumulation surveys were completed at two beach sites in Maui, Hawai ‘i before (2017) as well as throughout the initial year of the pandemic (2020–2021) and allowed for the assessment of pandemic-related restrictions on marine debris accumulation trends. Throughout the pandemic, reduced beach use due to higher lockdown levels had significant impacts on debris accumulation at both sites, but only one of the two sites experienced a significant decrease (~ 90% reduction) in debris accumulation rates when compared to the same months in 2017. Daily accumulation rates across two sites increased from an average of 16 items/100 m during peak lockdown levels to 43 items/100 m when restrictions eased. The observed fluctuations in debris accumulation rates, driven by changes in tourism and travel restrictions during the COVID-19 pandemic emphasize the importance of proactive measures to protect the natural environment, including source reduction and effective legislation for waste prevention. By addressing both local and remote sources of debris and focusing on reducing waste at its source, it is possible to mitigate the impacts of debris accumulation on coastal environments and marine life in Hawaiʻi.
Caregiver’s cognitive traits are associated with pup fitness in a cooperatively breeding mammal
Authors: Shelafoe C. , Thompson F. J. , Mwanguhya F. , Kyabulima S. , Businge R. , Mwesige K. , Sanderson J. L. , Cant M. A. , Marshall H. H. , Vitikainen E. I. K. 
Published: October 2023

AbstractStudies across diverse taxa have revealed the importance of early life environment and parenting on characteristics later in life. While some have shown how early life experiences can impact cognitive abilities, very few have turned this around and looked at how the cognitive skills of parents or other carers during early life affect the fitness of young. In this study, we investigate how the characteristics of carers may affect proxies of fitness of pups in the cooperatively breeding banded mongoose (Mungos mungo). We gave adult mongooses a spatial memory test and compared the results to the success of the pups those individuals cared for. Our results show a tradeoff between speed and accuracy in the spatial memory task, with those individuals which were faster to move between cups in the test arena making more erroneous re-visits to cups that they had already checked for food. Furthermore, the accuracy of their carer predicted future survival, but not weight gain of the pups and the effect was contrary to expected, with pups that were cared for by less accurate individuals being more likely to survive to adulthood. Our research also provides evidence that while younger carers were less accurate during the test, the age of the carer did not have an impact on the chance of raising young that live to sexual maturity. Our findings suggest that banded mongoose carers’ cognitive traits have fitness consequences for the young they care for, affecting the chance that these young live to maturity.
Optimal placement criteria of actuators for hybrid mounting system on a non-aligned plate structure
Authors: Qiu Yang , Hong Dongwoo , Kim Byeongil 
Published: October 2023

AbstractElectric motors in electric and hybrid vehicles generate mid-frequency noise and vibration. These factors cause drivers to experience discomfort while traveling. Active mounting techniques have been extensively researched and developed to effectively address this issue. The optimal placement of an active mounting system is essential for enhancing NVH performance when an active mounting system is utilized. In order to propose optimal location criteria for active paths, this paper concentrates on developing an analytical model based on both dynamic and static analysis. The secondary forces along active trajectories are mathematically determined when a structure is subjected to an excitation force. These locations are considered optimal for the active mounting system if the secondary forces are comparatively minimal. Simulations and feasibility experiments are also conducted in order to validate the proposed method. In addition, the results are compared with the case of beam structure. It has been determined through this procedure that the active path’s control performance will be enhanced if it is positioned in the optimal location and less control force is required than in the case of beam.
Fault diagnosis of anti-friction bearings based on Bi-dimensional ensemble local mean decomposition and optimized dynamic least square support vector machine
Authors: Xiong Zhengqiang , Han Chang , Zhang Guorong 
Published: October 2023

AbstractIn order to ensure the normal operation of rotating equipment, it is very important to quickly and efficiently diagnose the faults of anti-friction bearings. Hereto, fault diagnosis of anti-friction bearings based on Bi-dimensional ensemble local mean decomposition and optimized dynamic least square support vector machine (LSSVM) is presented in this paper. Bi-dimensional ensemble local mean decomposition, an extension of ensemble local mean decomposition from one-dimensional signal processing to Bi-dimensional signal processing, is used to extract the features of anti-friction bearings. Moreover, an optimized dynamic LSSVM is used to fault diagnosis of anti-friction bearings. The experimental results show that Bi-dimensional ensemble local mean decomposition is superior to Bi-dimensional local mean decomposition, optimized dynamic LSSVM is superior to traditional LSSVM, and the proposed Bi-dimensional ensemble local mean decomposition and optimized dynamic LSSVM method is effective for fault diagnosis of anti-friction bearings.
Chlorogenic acid protects against myocardial ischemia–reperfusion injury in mice by inhibiting Lnc Neat1/NLRP3 inflammasome-mediated pyroptosis
Authors: Chai Xin , Liang Zhengwei , Zhang Junshi , Ding Jing , Zhang Qian , Lv Sha , Deng Yazhu , Zhang Rongrui , Lu Deqin 
Published: October 2023

AbstractIncreasing evidences demonstrate that chlorogenic acid (CGA), a polyphenol with multiple effects such as anti-inflammatory and anti-oxidation, protects against myocardial ischemia–reperfusion injury (MIRI) in vitro and in vivo. But its detailed cardiac protection mechanism is still unclear. The MIRI mice model was established by ligating the left anterior descending branch (LAD) of the left coronary artery in C57BL/6 mice. Sixty C57BL/6 mice were randomly divided into four groups. CGA group and CGA + I/R group (each group n = 15) were gavaged with 30 mg/kg/day CGA for 4 weeks. Sham group and I/R group mice (each group n = 15) were administered equal volumes of saline. In vitro MIRI model was constructed by hypoxia and reoxygenation of HL-1 cardiomyocytes. The results showed that CGA pretreatment reduced myocardial infarction size and cTnT contents in serum, simultaneously reduced the levels of Lnc Neat1 expression and attenuated NLRP3 inflammasome-mediated pyroptosis in myocardial tissue. Consistent with in vivo results, the pretreatment of 0.2 μM and 2 μM CGA for 12 h in HL-1 cardiomyocytes depressed hypoxia/reoxygenation-induced Lnc Neat1 expression, NLRP3 inflammasome activation and pyroptosis. Lnc Neat1 shRNA transfection mediated by lentivirus in HL-1 cardiomyocytes significantly reduced activation of NLRP3 inflammasome and pyroptosis. Our findings suggest that CGA protects against MIRI by depressing Lnc Neat1 expression and NLRP3 inflammasome-mediated pyrotosis. Inhibiting the levels of Lnc Neat1 expression may be a therapeutic strategy for MIRI.
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections
Authors: Reinke Patrick Y. A. , de Souza Edmarcia Elisa , Günther Sebastian , Falke Sven , Lieske Julia , Ewert Wiebke , Loboda Jure , Herrmann Alexander , Rahmani Mashhour Aida , Karničar Katarina , Usenik Aleksandra , Lindič Nataša , Sekirnik Andreja , Botosso Viviane Fongaro , Santelli Gláucia Maria Machado , Kapronezai Josana , de Araújo Marcelo Valdemir , Silva-Pereira Taiana Tainá , Filho Antônio Francisco de Souza , Tavares Mariana Silva , Flórez-Álvarez Lizdany , de Oliveira Danielle Bruna Leal , Durigon Edison Luiz , Giaretta Paula Roberta , Heinemann Marcos Bryan , Hauser Maurice , Seychell Brandon , Böhler Hendrik , Rut Wioletta , Drag Marcin , Beck Tobias , Cox Russell , Chapman Henry N. , Betzel Christian , Brehm Wolfgang , Hinrichs Winfried , Ebert Gregor , Latham Sharissa L. , Guimarães Ana Marcia de Sá , Turk Dusan , Wrenger Carsten , Meents Alke 
Published: October 2023

AbstractSeveral drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we show that Calpeptin is an extremely potent cysteine cathepsin inhibitor, a finding additionally supported by X-ray crystallography. Cell infection assays proved Calpeptin’s efficacy against SARS-CoV-2. Treatment of SARS-CoV-2-infected Golden Syrian hamsters with sulfonated Calpeptin at a dose of 1 mg/kg body weight reduces the viral load in the trachea. Despite a higher risk of side effects, an intrinsic advantage in targeting host proteins is their mutational stability in contrast to highly mutable viral targets. Here we show that the inhibition of cathepsins, a protein family of the host organism, by calpeptin is a promising approach for the treatment of SARS-CoV-2 and potentially other viral infections.