bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reactivity of Isocyanate Radical with Formic Acid in the Tropospheric and Outer Space Regions: A DFT and MP2 Investigation in Gaseous Phase
Authors: Kabanda Mwadham M. , Bahadur Indra , Singh Prashant , Mohammad Faruq , Soleiman Ahmed Abdullah 
Published: December 2023

AbstractThis work aims to investigate the nature of the structures, mechanisms and kinetics associated with the prototype reaction of formic acid (FA) with NCO radical in either the troposphere or outer space regions. The kinetic properties have been investigated to include temperature in the cold outer space molecular clouds populated regions (typically between 10 and 100 K), temperature in the warm outer space molecular cloud regions (between 90–200 K) and temperature in the troposphere region of the atmosphere (200–400 K). The study has been performed by means of selected Density Functional Theory (DFT), second order Møller–Plesset perturbation theory (MP2) and transition state theory approaches. The results of the investigation suggest that the H2NCO carbamoyl radical and carbon dioxide are the final fate for the reaction involving NCO radical and FA. HOCNH radical is considered the least formed product of the NCO+FA reaction because all pathways leading to its formation are unfavourable with regards to other competitive processes. Of all the investigated reaction channels, the thermodynamically preferred reaction pathways involve cases in which the starting isocyanate radical species has its unpaired electron on the nitrogen atom (N⋅) rather than on its oxygen atom (O⋅).
A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid Using Carbon Paste/Copper Schiff Base Composite Electrode
Authors: Kulizić Mihajlo , Stanković Milan , Rašić Marija , Mijatović Aleksandar , Baošić Rada , Lolić Aleksandar 
Published: December 2023

AbstractIn this paper, a simple, sensitive, and precise flow injection system was optimized and applied to ascorbic acid determination with a carbon paste electrode modified with the Schiff base copper complex. The modified sensor showed increased sensitivity toward ascorbic acid oxidation with a decrease of oxidation potential by 200 mV. Under optimized flow parameters, working potential, gasket thickness, sample and reaction coil volumes, and flow rate, the developed flow system gave a linear response from 5 to 75 μmol/L of ascorbic acid. The calculated limit of detection was 4.5 μmol/L, calculated as 3σ/s which corresponds to the absolute value of 40 ng for the 50 μL sample coil. The precision for six consecutive injections of 5 and 75 μmol/L ascorbic acid solutions was determined as a relative standard deviation of 5.8 % and 1.5 %, respectively. The flow injection system enabled up to 120 analyses per hour. An optimized flow system was applied to the determination of ascorbic acid in dietary supplements, after simple preparation.
Specific Modification of Granular Potato Starch by Means of Partial Debranching Using Pullulanase
Authors: Ulbrich Marco , Bültena Matthias , Braun Burga , Meißner Karsten , Bussert Robert , Flöter Eckhard 
Published: December 2023

AbstractNative potato starch (PS‐N) is enzymatically modified in the granular state using pullulanase (PUL) for the purpose of a specific partial molecular degradation of the polymers. The PUL compound is added to the aqueous starch suspension (40%, w/w) and processed. The process parameters are varied systematically (enzyme dosage [ENZ] 4/20 mL; pH of the suspension [pH 4.7/7.3]; hydrolysis temperature [TEMP] 40/50 °C, and hydrolysis duration [TIME] 20/120 min) and a new‐developed heat‐induced enzyme inactivation approach (storage of the partially dewatered moist starch for 120 min at 100 °C) is intended to terminate the hydrolysis. Morphological (LM, SEM, and CLSM) and thermal characterization (DSC) of the starch products indicate a partial damage of the granules and a partial loss of the semicrystalline structure owing to the heat treatment, which is confirmed by XRD. The molecular properties (SEC‐MALS‐DRI) are mainly controlled by the factors ENZ, pH, and TEMP, but the intended degradation of the amylopectin (AP) by cleavage of the α‐1,6‐linkages (debranching) is accompanied by a molecular degradation of the amylose (AM) fraction. However, both specificity of the hydrolysis and achievable gel strength are remarkably improved compared to acid‐thinned products.
Multicenter development of a PET-based risk assessment tool for product-specific outcome prediction in large B-cell lymphoma patients undergoing CAR T-cell therapy
Authors: Voltin Conrad-Amadeus , Paccagnella Andrea , Winkelmann Michael , Heger Jan-Michel , Casadei Beatrice , Beckmann Laura , Herrmann Ken , Dekorsy Franziska J. , Kutsch Nadine , Borchmann Peter , Fanti Stefano , Kunz Wolfgang G. , Subklewe Marion , Kobe Carsten , Zinzani Pier Luigi , Stelljes Matthias , Roth Katrin S. , Drzezga Alexander , Noppeney Richard , Rahbar Kambiz , Reinhardt H. Christian , von Tresckow Bastian , Seifert Robert , Albring Jörn C. , Blumenberg Viktoria , Farolfi Andrea , Flossdorf Sarah , Gödel Philipp , Hanoun Christine 
Published: December 2023

Abstract
Purpose
The emergence of chimeric antigen receptor (CAR) T-cell therapy fundamentally changed the management of individuals with relapsed and refractory large B-cell lymphoma (LBCL). However, real-world data have shown divergent outcomes for the approved products. The present study therefore set out to evaluate potential risk factors in a larger cohort.

Methods
Our analysis set included 88 patients, treated in four German university hospitals and one Italian center, who had undergone 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (PET) before CAR T-cell therapy with tisagenlecleucel or axicabtagene ciloleucel. We first determined the predictive value of conventional risk factors, treatment lines, and response to bridging therapy for progression-free survival (PFS) through forward selection based on Cox regression. In a second step, the additive potential of two common PET parameters was assessed. Their optimal dichotomizing thresholds were calculated individually for each CAR T-cell product.

Results
Extra-nodal involvement emerged as the most relevant of the conventional tumor and patient characteristics. Moreover, we found that inclusion of metabolic tumor volume (MTV) further improves outcome prediction. The hazard ratio for a PFS event was 1.68 per unit increase of our proposed risk score (95% confidence interval [1.20, 2.35], P = 0.003), which comprised both extra-nodal disease and lymphoma burden. While the most suitable MTV cut-off among patients receiving tisagenlecleucel was 11 mL, a markedly higher threshold of 259 mL showed optimal predictive performance in those undergoing axicabtagene ciloleucel treatment.

Conclusion
Our analysis demonstrates that the presence of more than one extra-nodal lesion and higher MTV in LBCL are associated with inferior outcome after CAR T-cell treatment. Based on an assessment tool including these two factors, patients can be assigned to one of three risk groups. Importantly, as shown by our study, metabolic tumor burden might facilitate CAR T-cell product selection and reflect the individual need for bridging therapy.
Numerical Analysis of a Tunnel Passing through Jointed Rockmass
Authors: Verma Harshal , Ray Arunava , Rai Rajesh , Manna Bappaditya , Singh T. N. 
Published: December 2023

Abstract
With the increase in the pace of development, the demand for tunnels has increased in recent years. Analysing the stability of a tunnel in a fractured rock mass is a very challenging and cumbersome activity. The tunnel stability depends on the strength of the rock, joints bolt strength, in-situ stresses, and their orientation. This paper focuses on constructing tunnels in fractured/ jointed rock mass. Three different software namely Rocscience Phase2 (finite element based), FLAC3D (finite volume based) and PFC3D (distinct element based), were used to analyse the performance and stability under static and dynamic loading conditions. The geomaterial properties used for the analysis were taken from data obtained after laboratory testing and based on available literature. The effect of joint orientation and bolt length was analysed using Phase 2 assuming plain strain conditions. The effect of earthquake and performance of fully grouted, energy absorbing and deformation-controlled bolts under seismic loading conditions were compared using FLAC3D. While the 3D distinct element analysis of geometry was performed using PFC3D to evaluate the effect of joints and their orientation. The performance of the different types of bolts was also analysed numerically. The behaviour of bolts can be customised using the ‘fish’ function. The results indicate that analysis must incorporate the fusion of various numerical simulation techniques like finite element-, finite volume- and distinct element-based methods for more reliable results.
Challenging EU Sanctions against Russia: The Role of the Court, Judicial Protection, and Common Foreign and Security Policy
Authors: Lonardo Luigi 
Published: December 2023

AbstractThis Article deals with selected issues of judicial protection that arise in the context of the sanctions adopted by the EU against Russia and Belarus after the 2022 invasion of Ukraine. As most cases challenging the sanctions are pending, this Article draws lessons from the previous case law on EU restrictive measures. It explores what aspects of the sanctions escape judicial review, then profiles of external (or formal) legality of the sanctions, of internal (or substantive) legality, and concludes by assessing the overall role of the Court in EU foreign affairs. The discussion shows that the case law in this area of EU administrative law converges to a great extent with other areas of EU competence, but tensions remain in how the Court may impose substantial constraints to executive discretion in the field of Common Foreign and Security Policy.
Phytochemical profiling and anthelmintic potential of extracts of selected tropical plants on parasites of fishes in Epe Lagoon
Authors: Ukwa U. D. , Saliu J. K. , Akinsanya B. 
Published: December 2023

AbstractThis research aims to study the anthelmintic properties of selected five (5) tropical plant extracts, ascertained margin of fish host safety in reference with praziquantel, a commonly used chemo-therapeutics. Qualitative and quantitative analysis of Alligator pepper seeds (Aframomum melegueta), Moringa leaves (Moringa oleifera), Neem leaves (Azadirachta indica), Ginger bulbs (Zingiber officinale) and Garlic (Allium sativum) and their potencies in reference to praziquantel against Clarias gariepinus and different classes of helminth parasites were investigated. The results obtained show that the 70% ethanol extract had 80 to 100% presence of the phytochemical content, compared with the 100% aqueous and 100% ethanol extracts with 50 to 80% and 50 to 90%, respectively. Among the five tropical plants, the richest in saponin and flavonoids are alligator pepper and neem with alkaloids, tannin, flavonoid and saponin in ratios 1:1:3:9 and 1:1:4:3 respectively. While, moringa, garlic and ginger are rich in alkaloids with alkaloids, tannin, flavonoid and saponin in ratios, 8:1:10:1, 6:2:1:4 and 6:3:2:1, respectively. Aframomum melegueta and praziquantel showed above 70% potency (at 96 h LC5) against all the classes of parasites; Wenyonia spp (cestode), Procamallanus spp (nematode), Tenuisentis spp (acanthocephalan), and Electrotaenia sp (cestode) as compared to the other plant extracts that showed above 70% potency (at 96 h LC5) only against Electrotaenia spp. Sub-lethal Concentrations (96 h LC5) of praziquantel and Aframomum melegueta on the juvenile fish host (12.36 mg/l and 9.9 mg/l respectively) were found to be 90.9% and 93.5% effective against adult Electrotaenia spp after 8 to 10 min of exposure. These concentrations were 78 to 85.7% and 89.7 to 88.4%, respectively, effective against the other classes of parasites after 18 to 25 min and 15 to 21 min of exposure. These concentrations were tested on the post juvenile of the fish to determine behavioral changes; there were no significant behavioral responses after 24 h of exposure. The effective concentrations indicate the widest margin of safety for the fish host.
Research on robust fault-tolerant control of the controllable suspension based on knowledge-data fusion driven
Authors: Zhu Honglin , Ding Weiping , Yang Mingliang , Wu Yudong , Du Tong 
Published: December 2023

AbstractFor the robust fault-tolerant control of the controllable suspension system, a control strategy driven by knowledge-data fusion is proposed. Firstly, the boundary fuzziness between perturbation type uncertainty and gain type fault is analyzed, and then a data-driven method is introduced to avoid the state estimation of system uncertainty and fault. The proximal policy optimization algorithm in reinforcement learning is selected to construct a “data control law”, to deal with uncertainty and fault. On the other hand, based on the classical sky-hook control, the “knowledge control law” for system performance optimization is designed, taking into account the nonlinear and non-stationary characteristics of the system. Furthermore, the dependency between robust fault tolerance and performance optimization control is revealed, and the two control laws are fused by numerical multiplication, to realize the performance matching optimization control of robust fault tolerance of controllable suspension system driven by knowledge-data fusion. Finally, the effectiveness and feasibility of the proposed method are verified by the simulation and real-time experiment of non-stationary excitation and near-stationary excitation under the combination of uncertainty and fault.
Application of unsupervised clustering model based on graph embedding in water environment
Authors: Fang Meng , Lyu Li , Wang Ning , Zhou Xiaolei , Hu Yankun 
Published: December 2023

AbstractSurface water monitoring data has spatiotemporal characteristics, and water quality will change with time and space in different seasons and climates. Data of this nature brings challenges to clustering, especially in terms of obtaining the temporal and spatial characteristics of the data. Therefore, this paper proposes an improved TADW algorithm and names it RTADW to obtain the spatiotemporal characteristics of surface water monitoring points. We improve the feature matrix in TADW and input the original time series data and spatial information into the improved model to obtain the spatiotemporal feature vector. When the improved TADW model captures watershed information for clustering, it can simultaneously extract the temporal and spatial characteristics of surface water compared with other clustering algorithms such as the DTW algorithm. We applied the proposed method to multiple different monitoring sites in the Liaohe River Basin, analyzed the spatiotemporal regional distribution of surface water monitoring points. The results show that the improved feature extraction method can better capture the spatiotemporal feature information between surface water monitoring points. Therefore, this method can provide more potential information for cluster analysis of water environment monitoring, thereby providing a scientific basis for watershed zoning management.
An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis
Authors: Jörgensen Sara KM , Karnošová Alena , Mazzaferro Simone , Rowley Oliver , Chen Hsiao-Jou Cortina , Robbins Sarah J , Christofides Sarah , Merkle Florian T , Maletínská Lenka , Petrik David 
Published: December 2023

AbstractHypothalamic Adult Neurogenesis (hAN) has been implicated in regulating energy homeostasis. Adult-generated neurons and adult Neural Stem Cells (aNSCs) in the hypothalamus control food intake and body weight. Conversely, diet-induced obesity (DIO) by high fat diets (HFD) exerts adverse influence on hAN. However, the effects of anti-obesity compounds on hAN are not known. To address this, we administered a lipidized analogue of an anti-obesity neuropeptide, Prolactin Releasing Peptide (PrRP), so-called LiPR, to mice. In the HFD context, LiPR rescued the survival of adult-born hypothalamic neurons and increased the number of aNSCs by reducing their activation. LiPR also rescued the reduction of immature hippocampal neurons and modulated calcium dynamics in iPSC-derived human neurons. In addition, some of these neurogenic effects were exerted by another anti-obesity compound, Liraglutide. These results show for the first time that anti-obesity neuropeptides influence adult neurogenesis and suggest that the neurogenic process can serve as a target of anti-obesity pharmacotherapy.
Cep120 is essential for kidney stromal progenitor cell growth and differentiation
Authors: Langner Ewa , Cheng Tao , Kefaloyianni Eirini , Gluck Charles , Wang Baolin , Mahjoub Moe R 
Published: December 2023

AbstractMutations in genes that disrupt centrosome structure or function can cause congenital kidney developmental defects and lead to fibrocystic pathologies. Yet, it is unclear how defective centrosome biogenesis impacts renal progenitor cell physiology. Here, we examined the consequences of impaired centrosome duplication on kidney stromal progenitor cell growth, differentiation, and fate. Conditional deletion of the ciliopathy gene Cep120, which is essential for centrosome duplication, in the stromal mesenchyme resulted in reduced abundance of interstitial lineages including pericytes, fibroblasts and mesangial cells. These phenotypes were caused by a combination of delayed mitosis, activation of the mitotic surveillance pathway leading to apoptosis, and changes in both Wnt and Hedgehog signaling that are key for differentiation of stromal cells. Cep120 ablation resulted in small hypoplastic kidneys with medullary atrophy and delayed nephron maturation. Finally, Cep120 and centrosome loss in the interstitium sensitized kidneys of adult mice, causing rapid fibrosis after renal injury via enhanced TGF-β/Smad3-Gli2 signaling. Our study defines the cellular and developmental defects caused by loss of Cep120 and aberrant centrosome biogenesis in the embryonic kidney stroma.
A systematic search for double eclipsing binaries in Zwicky Transient Facility data
Authors: Vaessen T. , van Roestel J. 
Published: December 2023

Context. Double eclipsing binaries are gravitationally bound quadruple systems in a ‘2+2’ configuration where both of the binaries are eclipsing. These systems are interesting objects to better understand stellar formation, to investigate the dynamical interaction between the two binary systems, or to study certain stages of stellar evolution, such as common-envelope events or Type Ia Supernovae.
Aims. With this work, we aim to determine if double eclipsing binaries can be found using ZTF data and what the difficulties are in doing so. Secondly, we aim to significantly increase the number of known double eclipsing systems and determine how this sample differs from samples of double eclipsing binaries found with other telescopes.
Methods. We developed a new method to systematically search for double eclipsing binaries in sparsely sampled light curves. For this we used box-least-squares (BLS) to search for the period of the first binary in the system. We then removed that signal from the light curves, and searched the residual light curve again with BLS to find the second period. We applied this method to ZTF light curves of 575 526 eclipsing binaries known in the Gaia eclipsing binary catalogue.
Results. We report the discovery of 198 new double eclipsing binary systems. The shortest and longest orbital periods of the newly detected systems are 0.11 days to 323 days respectively.
Conclusions. We successfully implemented a method that systematically searches for double eclipsing binary systems in sparsely sampled data. In total 198 new double eclipsing binary systems have been found in 575 5 26 light curves (≈0.034%). The ZTF sample typically contains more short period binaries compared to the TESS sample, but is also able to find systems with longer periods than what is currently known. We expect that at least three to four times more quadruples can be found by applying this method to all ZTF stellar light curves, by increasing the number of data points as a result of longer observations, and by implementing an automatic detection mechanism that replaces visual inspection.
Processus psychiques dans la possession. Réflexion à partir de quelques pratiques traditionnelles au Maroc
Authors: Lebbar Hakima 
Published: December 2023

Dans le présent travail, la notion de possession fait référence aux djinns car ce sont ces dernier.e.s qui vont « prendre, habiter ou posséder » les humains. Après de nombreuses années de recherche sur le terrain au Maroc, je présente ici deux praticiens, un fqih de la confrérie de Bouya Omar et une voyante de la confrérie des Gnawas, dont j’ai suivi la consultation pendant plusieurs années. J’ai essayé d’interroger autant leur cheminement pour devenir praticien.ne que leur pratique quotidienne. À travers une grille psychanalytique j’analyse les croyances sous-jacentes aux pratiques traditionnelles, la question de leur survivance, le rapport praticien/malade et les processus psychiques en jeu quant à une supposée efficacité.
Dans le cadre d’une adhésion collective à des croyances ancestrales qui font LOI, certaines souffrances physiques et psychiques peuvent être le fait du symbolique agissant dans l’organisme et le corps en interdépendance avec les croyances collectives ancestrales. Si les pratiques traditionnelles ne peuvent proposer un vrai projet où le Je s’implique, elles apportent certainement du réconfort, du soutien et aident à tenir (et je vais oser cette comparaison) comme l’Art peut offrir une issue aux artistes, pour tenir.
J’ai essayé de produire un texte riche en informations sur le monde des croyances ancestrales et des pratiques traditionnelles au Maroc tout en suivant le trajet de la réflexion présentée ci- dessus.
Harvest more bridge vibration energy by nonlinear multi-stable piezomagnetoelastic harvester
Authors: Zhou Zhiyong , Huang Haobo , Cao Di , Qin Weiyang , Zhu Pei , Du Wenfeng 
Published: December 2023

Abstract
The idea of using bridge vibration energy to power node sensors is promising in solving the power problems of bridge health monitoring systems. This study proposes a piezomagnetoelastic harvester that tries utilizing nonlinear multi-stability to improve the harvesting performance of bridge vibration energy. The harvester can exhibit multi-stable behaviors due to the introduced nonlinear forces. The potential energy functions are derived and corresponding analyzes are carried out. The results show that the tri-stable state of harvester can be obtained by adjusting the parameters related to magnetic forces. Its potential barriers are low and the distance between potential wells is large, so it can execute snap-through motion easily. The experimental study was carried out for different vehicle speeds. The results verify that the energy harvester in a tri-stable state can generate the largest electric output over a wide range of vehicle speeds. Moreover, it is proved that the tri-stable state can protect the harvester from excessive deformation and subsequent damage. Therefore, the tri-stable configuration has a potential advantage in bridge vibration energy harvesting and providing power for self-powered sensors.