bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Simulations of Warm Rain in a Bulk Microphysics Scheme
Authors: Conrick Robert , Mass Clifford F. , McMurdie Lynn 
Published: November 2023

Abstract
Current bulk microphysical parameterization schemes underpredict precipitation intensities and drop size distributions (DSDs) during warm rain periods, particularly upwind of coastal terrain. To help address this deficiency, this study introduces a set of modifications, called RCON, to the liquid-phase (warm rain) parameterization currently used in the Thompson–Eidhammer microphysical parameterization scheme. RCON introduces several model modifications, motivated by evaluating simulations from a bin scheme, which together result in more accurate precipitation simulations during periods of warm rain. Among the most significant changes are 1) the use of a wider cloud water DSD of lognormal shape instead of the gamma DSD used by the Thompson–Eidhammer parameterization and 2) enhancement of the cloud-to-rain autoconversion parameterization. Evaluation of RCON is performed for two warm rain events and an extended period during the Olympic Mountains Experiment (OLYMPEX) field campaign of winter 2015/16. We show that RCON modifications produce more realistic precipitation distributions and rain DSDs than the default Thompson–Eidhammer configuration. For the multimonth OLYMPEX period, we show that rain rates, rainwater mixing ratios, and raindrop number concentrations were increased relative to the Thompson–Eidhammer microphysical parameterization, while concurrently decreasing raindrop diameters in liquid-phase clouds. These changes are consistent with an increase in simulated warm rain. Finally, real-time evaluation of the scheme from August 2021 to August 2022 demonstrated improved precipitation prediction over coastal areas of the Pacific Northwest.

Significance Statement
Although the accurate simulation of warm rain is critical to forecasting the hydrology of coastal areas and windward slopes, many warm rain parameterizations underpredict precipitation in these locations. This study introduces and evaluates modifications to the Thompson–Eidhammer microphysics parameterization scheme that significantly improve the accuracy of rainfall prediction in those regions.
EBEI: A new index of eye bank efficiency
Authors: Aiello Francesco , Gallo Afflitto Gabriele , Ceccarelli Francesca , Cesareo Massimo , Griffoni Carlo , Ponzin Diego , Nucci Carlo 
Published: November 2023

Purpose To describe a new proxy of the Eye Bank (EB) activity named “Eye Bank Efficiency Index” (EBEI), calculated as the ratio between the number of corneal tissues distributed by an EB within a certain time period, and the difference between the number of procured and discarded tissues. Methods To demonstrate the effectiveness of the new metric as compared to traditional statistics, an analysis was conducted using data from the largest Italian Eye Bank (Fondazione Banca degli Occhi del Veneto Venice, Italy). Collected data included: the number of corneas retrieved, the number of discarded grafts, and the number of distributed tissues. The analysis focused on three defined timeframes: January to December, March to May (the “Italian Lockdown period”), and June to December (the “Italian post-lockdown period”). Results In 2020, the annual variation of the EBEI showed a significant increase of up to 3.4% compared to the previous year (0.986 in 2019; 1.020 in 2020), but then gradually decreased to 0.993 in 2022. However, during the months of lockdown in 2020, there was a significant decline of −13.8% in the EBEI compared to the same period in the previous year. The variation in the EBEI during the post-lockdown months was minimal in 2020 and 2021, with the lowest EBEI value of 0.976 being reached in 2022 (−7.8% compared to 2019). Conclusion The EBEI is a simple and reliable new measure of the EB activity. Its widespread adoption could ensure a more accurate and reliable analysis of EB data for academic, political, and economic purposes.
Assessing progress in managing and improving quality in nascent integrated care systems in England
Authors: Lalani Mirza , Sugavanam Priya , Caiels James , Crocker Helen , Gunn Sarah , Hay Harriet , Hogan Helen , Page Bethan , Peters Michele , Fitzpatrick Ray 
Published: November 2023

Objectives In 2022, England embarked on an ambitious reorganisation to produce an integrated health and care system, intended also to maximise population health. The newly created integrated care systems (ICSs) aim to improve quality of care, by achieving the best outcomes for individuals and populations through the provision of evidence-based services. An emerging approach for managing quality in organisations is the Quality Management System (QMS) framework. Using the framework, this study assessed how ICSs are managing and improving quality. Methods Four ICSs were purposively sampled, with the data collected between November 2021 and May 2022. Semi-structured interviews with system leaders ( n=60) from health and social care, public health and local representatives were held. We also observed key ICS meetings and reviewed relevant documents. A thematic framework approach based on the QMS framework was used to analyse the data. Results The ICSs placed an emphasis on population health, reducing inequity and improving access. This represents a shift in focus from the traditional clinical approach to quality. There were tensions between quality assurance and improvement, with concerns that a narrow focus on assurance would impede ICSs from addressing broader quality issues, such as tackling inequalities and unwarranted variation in care and outcomes. Partnerships, a key enabler for integration, was seen as integral to achieving improvements in quality. Overall, the ICSs expressed concerns that any progress made in quality development and in improving population health would be tempered by unprecedented system pressures. Conclusion It is unclear whether ICSs can achieve their ambition. As they move away from an assurance-dominated model of quality to one that emphasises openness, learning and improvement, they must simultaneously build the digital infrastructure, staff expertise and culture to support such a shift.
Safety and Efficacy of Tranexamic Acid in Total Ankle Arthroplasty
Authors: Ghobrial Philip G. , Eikani Carlo K. , Schmitt Daniel R. , Brown Nicholas M. , Pinzur Michael S. , Schiff Adam P. 
Published: November 2023

Tranexamic acid has been shown to significantly reduce blood loss in patients undergoing total knee arthroplasty and total hip arthroplasty. However, there is a paucity of data regarding its safety and efficacy in total ankle arthroplasty. The purpose of this study was to determine whether tranexamic acid use in patients with total ankle arthroplasty affects blood loss or overall complication rate. A retrospective chart review was conducted for 64 patients who underwent total ankle arthroplasty with (n = 32) and without (n = 32) intraoperative tranexamic acid from 2014 to 2023 at a single academic medical center. Recorded blood loss, pre-to-postoperative hemoglobin changes, hidden blood loss, and complication rates were recorded and compared. There was no statistically significant difference in recorded blood loss, total calculated blood loss, pre-to-postoperative hemoglobin difference, hidden blood loss, or overall complications between the groups (all, P > .05). A lower rate of wound complications was observed in the tranexamic acid group, but the difference between each group was not statistically significant (P > .05). Tranexamic acid did not decrease blood loss during total ankle arthroplasty, as measured in our study. Tranexamic acid was not associated with any increase in overall complications. Based on our findings, tranexamic acid may be a safe intervention in total ankle arthroplasty, but further studies are needed to better elucidate its clinical impact. Level of Evidence: Level 3
From “Extensive” to “Connotative” Development: Modernization of Chinese-Style Education
Authors: Yang (杨九诠) Jiuquan 
Published: November 2023

Highlights The transformation of China's education reform from extensive to connotative development involved a shift from characteristically exogenous and late development to endogenous and spontaneous development. The mechanism behind the shift from rationalism to universalism has resulted in tension between extension and intension in the process of modernization. Reflexive modernity has always existed in historical experience and situations, strengthening the appeal of intension to the right of defining. In terms of the scale effect, the expansion of higher education enrollment made historically significant contributions to the modernization of education in China; however, it also had several disadvantages. China's educational modernization invariably requires solving the problem of large-class teaching and promoting small-class teaching in the process of shifting from extensive to connotative development.
Leading a post-pandemic workforce: Understanding employees’ changing work ethic
Authors: Arciniega Luis M , Woehr David J , González Luis 
Published: November 2023

A recent cross-cultural study suggests employees may be classified, based on their scores on a measure of work ethic, into three profiles labeled as “live to work,” “work to live,” and “work as a necessary evil.” The present study assesses whether these profiles were stable before and after an extended lockdown that forced employees to work from home for 2 years because of the COVID-19 pandemic. To assess our core research question, we conducted a longitudinal study with employees of a company in the financial sector, collecting data in two waves: February 2020 ( n = 692) and June 2022 ( n = 598). Tests of profile similarity indicated a robust structural and configural equivalence of the profiles before and after the lockdown. As expected, the prolonged pandemic-based lockdown had a significant effect on the proportion of individuals in each profile. Implications for leading and managing in a post-pandemic workforce are presented and discussed. JEL CLASSIFICATION: M12
Well-Dispersed Graphene Enhanced Lithium Complex Grease Toward High-Efficient Lubrication
Authors: Lin Kaiyue , Zhao Zhuang , Li Yuting , Zeng Zihan , Wei Xiaofeng , Fan Xiaoqiang , Zhu Minhao 
Published: November 2023

AbstractGraphene as a lubricating additive holds great potential for industrial lubrication. However, its poor dispersity and compatibility with base oils and grease hinder maximizing performance. Here, the influence of graphene dispersion on the thickening effect and lubrication function is considered. A well-dispersed lubricant additive was obtained via trihexyl tetradecyl phosphonium bis(2-ethylhexyl) phosphate modified graphene ([P66614][DEHP]-G). Then lithium complex grease was prepared by saponification with 12-OH stearic acid, sebacic acid, and lithium hydroxide, using polyalphaolefin (PAO20) as base oil and the modified-graphene as lubricating additive, with the original graphene as a comparison. The physicochemical properties and lubrication performance of the as-prepared greases were evaluated in detail. The results show that the as-prepared greases have high dropping point and colloidal stability. Furthermore, modified-graphene lithium complex grease offered the best friction reduction and anti-wear abilities, manifesting the reduction of friction coefficient and wear volume up to 18.84% and 67.34%, respectively. With base oil overflow and afflux, well-dispersed [P66614][DEHP]-G was readily adsorbed to the worn surfaces, resulting in the formation of a continuous and dense graphene deposition film. The synergy of deposited graphene-film, spilled oil, and adhesive grease greatly improves the lubrication function of grease. This research paves the way for modulating high-performance lithium complex grease to reduce the friction and wear of movable machinery.
Bernese periacetabular osteotomy (PAO): from its local inception to its worldwide adoption
Authors: Ganz Reinhold , Leunig Michael 
Published: November 2023

AbstractThe development of the Bernese periacetabular osteotomy (PAO) is based on a structured approach starting with an analysis of the preexisting procedures to improve the coverage of the femoral head and was followed by a list of additional goals and improvements. Cadaveric dissections with a detailed description of the vascular supply of acetabulum and periacetabular bone set the stage for an intrapelvic approach, which offered the largest acetabular correction possible combined with safe intracapsular access. The final composition of osteotomies required the development of several instruments and cutting devices before the feasibility could be tested on a series of cadaveric hips.While the sequence of the osteotomies remained largely unchanged over time (except for the pubic and ischial osteotomies), several propositions for an easier/less invasive approach have been discussed; some made it into standard practice. Efforts were undertaken to optimize the learning curve and minimize failures using video-clips, hands-on courses, fellowships, publications, and ongoing mentoring programs. In retrospect, with almost 40 years of experience, such efforts have promoted a worldwide adoption of the Bernese periacetabular osteotomy.
3-D chromatin conformation, accessibility, and gene expression profiling of triple-negative breast cancer
Authors: Llinàs-Arias Pere , Ensenyat-Méndez Miquel , Orozco Javier I. J. , Íñiguez-Muñoz Sandra , Valdez Betsy , Wang Chuan , Mezger Anja , Choi Eunkyoung , Tran Yan Zhou , Yao Liqun , Bonath Franziska , Olsen Remi-André , Ormestad Mattias , Esteller Manel , Lupien Mathieu , Marzese Diego M. 
Published: November 2023

Abstract
Objectives
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. Unlike other breast cancer subtypes, the scarcity of specific therapies and greater frequencies of distant metastases contribute to its aggressiveness. We aimed to find epigenetic changes that aid in the understanding of the dissemination process of these cancers.

Data description
Using CRISPR/Cas9, our experimental approach led us to identify and disrupt an insulator element, IE8, whose activity seemed relevant for cell invasion. The experiments were performed in two well-established TNBC cellular models, the MDA-MB-231 and the MDA-MB-436. To gain insights into the underlying molecular mechanisms of TNBC invasion ability, we generated and characterized high-resolution chromatin interaction (Hi-C) and chromatin accessibility (ATAC-seq) maps in both cell models and complemented these datasets with gene expression profiling (RNA-seq) in MDA-MB-231, the cell line that showed more significant changes in chromatin accessibility. Altogether, our data provide a comprehensive resource for understanding the spatial organization of the genome in TNBC cells, which may contribute to accelerating the discovery of TNBC-specific alterations triggering advances for this devastating disease.
The molecular architecture of a complex social behavior: gregarious song
Authors: Stevenson Tyler J. 
Published: November 2023

AbstractThe medial preoptic area (mPOA) regulates the probability and intensity of singing behavior in birds. Polzin and colleagues examined the molecular changes in the mPOA that were associated with gregarious song in European starlings (Sturnus vulgaris). High-throughput transcriptome analyses identified glutamate and dopamine pathways were highly enriched with gregarious song.
Nurse practitioner led implementation of huddles for staff in long term care homes during the COVID-19 pandemic
Authors: McGilton Katherine S , Krassikova Alexandra , Wills Aria , Bethell Jennifer , Boscart Veronique , Escrig-Pinol Astrid , Iaboni Andrea , Vellani Shirin , Maxwell Colleen , Keatings Margaret , Stewart Steven C. , Sidani Souraya 
Published: November 2023

Abstract
Background
Staff working in long-term care (LTC) homes during COVID-19 frequently reported a lack of communication, collaboration, and teamwork, all of which are associated with staff dissatisfaction, health concerns, lack of support and moral distress. Our study introduced regular huddles to support LTC staff during COVID-19, led by a Nurse Practitioner (NP). The objectives were to evaluate the process of huddle implementation and to examine differences in outcomes between categories of staff (direct care staff, allied care and support staff, and management) who attended huddles and those who did not.

Methods
All staff and management at one LTC home (< 150 beds) in Ontario, Canada were included in this pre-experimental design study. The process evaluation used a huddle observation tool and focused on the dose (duration, frequency) and fidelity (NP’s adherence to the huddle guide) of implementation. The staff attending and non-attending huddles were compared on outcomes measured at post-test: job satisfaction, physical and mental health, perception of support received, and levels of moral distress. The outcomes were assessed with validated measures and compared between categories of staff using Bayesian models.

Results
A total of 42 staff enrolled in the study (20 attending and 22 non-attending huddles). Forty-eight huddles were implemented by the NP over 15 weeks and lasted 15 min on average. Huddles were most commonly attended by direct care staff, followed by allied care/support, and management staff. All huddles adhered to the huddle guide as designed by the research team. Topics most often addressed during the huddles were related to resident care (46%) and staff well-being (34%). Differences were found between staff attending and non-attending huddles: direct care staff attending huddles reported lower levels of overall moral distress, and allied care and support staff attending huddles perceived higher levels of support from the NP.

Conclusions
NP-led huddles in LTC homes may positively influence staff outcomes. The process evaluation provided some understanding of why the huddles may have been beneficial: the NP addressed resident care issues which were important to staff, encouraged a collaborative approach to solving issues on the unit, and discussed their well-being.

Trial registration number
NCT05387213, registered on 24/05/2022.
Real-world treatment patterns of OTX-101 ophthalmic solution, cyclosporine ophthalmic emulsion, and lifitegrast ophthalmic solution in patients with dry eye disease: a retrospective analysis
Authors: Karpecki Paul , Barghout Victoria , Schenkel Brad , Huynh Lynn , Khanal Anamika , Mitchell Brittany , Yenikomshian Mihran , Zanardo Enrico , Matossian Cynthia 
Published: November 2023

Abstract
Background
Dry eye disease (DED) is a disorder characterized by loss of tear film homeostasis that causes ocular surface inflammation and damage. The incidence of DED increases with age. Cyclosporine ophthalmic solution 0.09% (CEQUA®; OTX-101), cyclosporine ophthalmic emulsion 0.05% (Restasis®; CsA), and lifitegrast ophthalmic solution 5% (Xiidra®; LFT) are anti-inflammatory agents indicated for DED. This analysis compared treatment patterns in patients with DED receiving OTX-101, CsA, or LFT.

Methods
This real-world, retrospective, longitudinal cohort study utilized Symphony Health Integrated Dataverse claims from July 2019 to June 2021. The dataset included all patients with OTX-101 claims and patients with CsA or LFT claims randomly selected 2:1 to OTX-101. Patients were sorted into 3 cohorts based on index treatment. Index date was that of first treatment claim, and follow-up period was from index date to end of clinical activity or data availability. Time to treatment discontinuation (TTD), probability of discontinuation, and treatment persistence were assessed for OTX-101 vs. CsA, then OTX-101 vs. LFT. Subgroup analysis was performed based on age and prior DED treatment. Kaplan-Meier analysis and log-rank test were used to examine TTD. A logistic model evaluated association between index treatment and discontinuation. Unadjusted and adjusted odds ratios, 95% confidence intervals, and P-values were reported, with statistically significant associations based on P-values < 0.05.

Results
Overall, 7102 patients (OTX-101 n = 1846; CsA n = 2248; LFT n = 3008) were eligible. Median TTD was 354 days for patients receiving OTX-101 vs. 241 days for CsA and 269 days for LFT. Log-rank test indicated TTD was significantly longer for patients on OTX-101 vs. CsA (P = 0.033). Patients on CsA were 35% more likely to discontinue treatment than patients on OTX-101; OTX-101 and LFT groups had similar discontinuation rates. After 360 days, 49.8% of patients receiving OTX-101 remained on treatment vs. 39.4% of patients on CsA (P = 0.036) and 44.0% of patients on LFT (P = 0.854).

Conclusions
Patients receiving OTX-101 remained on treatment significantly longer and were significantly less likely to discontinue treatment than patients on CsA. Older patients remained on OTX-101 significantly longer than CsA. These findings highlight treatment pattern differences in patients with DED receiving these anti-inflammatory agents.
Knowledge, psychological impacts, and protective behaviours during the first wave of the COVID-19 pandemic among Chinese residents in Canada with dependent school-age children: a cross-sectional online study
Authors: Kong Yujia , Shaver Lance Garrett , Shi Fuyan , Yang Lixia , Zhang Weiguo , Wei Xiaoling , Zhang Eleen , Ozbek Sara , Effiong Andem , Wang Peizhong Peter 
Published: November 2023

Abstract
Background
The purpose of this study was to describe the knowledge, protective behaviours, and psychological impact of COVID-19 on Chinese residents in Canada, as the emotional and behavioural impacts of the pandemic have not been intensively studied amongst these populations. It was important to determine whether having dependent school-age children (DSAC) aged 16 or under was associated with adverse psychological impacts amongst the Chinese residents living in the country.

Methods
In April 2020, 757 eligible participants were recruited through a snowball sampling to complete an online survey related to the COVID-19 pandemic. Psychological, behavioural, and sociodemographic variables were collected and first analyzed using descriptive and univariate statistics. Multiple logistic regression analyses were performed to further confirm the observed significant associations in bivariate analyses for selected psychological outcome variables.

Results
Seven hundred forty-two participants who responded to the “dependent school-age children” question were included in the analysis. Most of them identified as females (65.8%) and 77.2% included receiving a university degree or higher. There were no significant differences in COVID-19 knowledge between those living with or without DSAC. However, participants with DSAC were more likely to perceive themselves as being at greater risk of contracting COVID-19 (p = .023); therefore, having a higher chance of adopting protective behaviours (e.g., hand washing, sanitizing frequently or disinfecting work and living spaces (p < .05), elevated risks of depression (p = .007), and stress (p = .010), compared to those without DSAC.

Conclusions
Predominantly, the Chinese residents in Canada with dependent school-age children were more likely to report the negative psychological impacts of the pandemic. These findings warrant further investigations that may contribute to informing key stakeholders about the identification and implementation of policies and interventions to support the needs of parents with young children, during and after the pandemic.