bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐year outcome of selective caries removal versus pulpotomy treatment of deep caries: A pilot randomized controlled trial
Authors: Chua S. K. X. , Sim Y. F. , Wang W. C. , Mok B. Y. Y. , Yu V. S. H. 
Published: October 2023

AbstractAimThis study aimed to compare the outcome of SCR and Pulpotomy in teeth with deep caries extending at least 75% into dentine.MethodologyThis two‐armed, parallel‐group, randomized, superiority trial included vital mature permanent teeth with deep primary or secondary caries diagnosed radiographically as being at least 75% into the thickness of dentine, without clinical signs of symptomatic irreversible pulpitis or radiographic evidence of a periapical lesion. Carious teeth were blindly allocated to receive either SCR or Pulpotomy using computer‐generated randomized patient codes concealed in opaque envelopes. All teeth were reviewed clinically and radiographically at 6 months and 1 year post‐treatment. Using a significance level of p < .05, the log rank test and Cox proportional hazards regression were used to compare the outcome of SCR and Pulpotomy and to identify potential prognostic factors, respectively.ResultsIn all, 58 teeth in the SCR group and 55 teeth in the pulpotomy group completed treatment, after excluding 6 teeth because they did not complete the allocated treatment and another due to severe periodontal disease. At one year, 57/58 (98.3%) teeth from the SCR group and 48/55 (87.3%) teeth from the Pulpotomy group were available for analysis. One tooth in the Pulpotomy group (2.1%) and eight teeth in the SCR group (14.0%) required the further intervention of root canal treatment (p < .05). There were no other significant prognostic factors for survival. Overall, 91.4% of teeth treated with either SCR or Pulpotomy survived without requiring further intervention over a period of one year. No other adverse events occurred over the review period.ConclusionWithin the limitations of this study, Pulpotomy fares better than SCR in preserving the remaining pulp and periapical health. As a treatment modality, Pulpotomy carries greater cost outlay to patient and takes a longer time to complete treatment than SCR. Long‐term follow‐up is needed to study the pulpal and restorative outcomes of Pulpotomy and SCR.
Consumer well‐being—A systematic literature review and research agenda usingTCCMframework
Authors: Bhardwaj Priya , Kalro Arti D. 
Published: October 2023

AbstractConsumer well‐being (CWB) refers to the cognitive and emotional reactions of consumers in response to their consumption experiences. It encompasses three elements: consumer satisfaction, positive emotions and perceived quality of life. In the past few years, there has been significant research growth in the field of CWB. However, a lack of effort is observed in reviewing this emerging and evolving field of research. This review utilises the Theory–Context–Construct–Methods (TCCM) framework given by Paul and Rosado‐Serrano (2019) (International Marketing Review,36(6), 830–858), to delve into the prominent theories, contexts (i.e., countries and industries), characteristics (major factors and variables) and methods (i.e., research designs and analysis) used in CWB research spanning over the past 24 years (1998–2022). Through a systematic analysis and synthesis of 142 articles, an overview of this research field is provided, establishing a path for future agenda within the TCCM framework. This review reveals a prevalence of single‐theory approaches, with studies primarily focusing on theories such as the self‐determination theory and the attribution theory. Furthermore, CWB research demonstrates a stronger inclination towards examining the services industry context compared to other industries covered in the literature. Additionally, the review emphasises the need for further research on countries with emerging economies. Detailed future research directions are presented.
Generation Z's perceptions of a good life beyond consumerism: Insights from the United States and Finland
Authors: Grénman Miia , Hakala Ulla , Mueller Barbara , Uusitalo Outi 
Published: October 2023

AbstractThis paper examines Generation Z consumers' perceptions of a good life beyond consumerism and how their perceptions and practices have evolved during crises and the cultural context in which they live. We present a unique theoretical and empirical cross‐cultural investigation which focuses on the ecological crisis and COVID‐19 pandemic, and the changes they have caused to Gen Zs' daily lives in the United States (California) and Finland. Two large qualitative data sets were collected through focus group interviews and open‐ and closed‐ended surveys before and during COVID‐19 and analyzed via the PERMA framework. Findings revealed that Gen Zs' pathways that lead to a good life include: healthy behaviors and balance; positive and meaningful relationships; happiness and positivity; meaningful things; productivity and goals; and daily routines. Findings also indicated that since COVID‐19, Gen Zs are increasingly shifting toward virtuous behaviors and eudaimonic‐oriented life, in which moderation, meaningfulness, and self‐realization play key roles. Gen Zs are characterized as a global consumer cohort and a driver of change for a sustainable future, thus understanding how these future professionals, leaders, and mainstream consumers perceive a good life provides theoretical and practical insights into how to provide ecologically sustainable well‐being for nature and future generations.
Optimised extraction of phospholipids and omega‐3 fatty acids from Patagonian squid waste with low‐toxicity solvents
Authors: Rodríguez Alicia , Trigo Marcos , Aubourg Santiago P. , Medina Isabel 
Published: October 2023

SummaryExtracting conditions of lipid compounds (phospholipids, PLs; ω3 fatty acids, FAs) from Patagonian squid (Doriteuthis gahi) waste were optimised by employment of a Simplex‐Lattice design. For it, different concentrations of low‐toxicity solvents (ethanol, acetone and ethyl acetate; single and binary and ternary mixtures) were tested. As a result, the multiple regressionanovaproved that the quadratic model was significant (P < 0.05) for PL and eicosapentaenoic acid (EPA) contents and for total polyunsaturated/total saturated and total ω3/total ω6 FA ratios. Thus, theanovaapplication of the fitting model led to the following optimised values for such parameters: 477.42 g kg−1lipids, 21.48 g 100 g−1total FAs, 3.48 and 13.03, respectively. The combination of process variable levels which maximised the desirability function (0.49 value) was ethanol/ethyl acetate (0.50:0.50, v/v) and led to values of 412.50 (g kg−1lipids), 19.05 (g 100 g−1total FAs), 2.59 and 12.86, respectively, for the above‐mentioned lipid parameters. Results were compared to those obtained by the conventional chloroform/methanol procedure. By including an advanced mathematical design, a novel eco‐friendly strategy based on the employment of low‐toxicity solvents is proposed for the extraction from a marine waste substrate of highly valuable lipid compounds with healthy and nutritional properties.
Familial Mediterranean fever and microRNAs
Authors: Bildirici Aslihan Esra 
Published: October 2023

AbstractFamilial Mediterranean fever (FMF) is an inherited disorder caused by the gain of function mutations in MEFV (MEditerranean FeVer) gene loci. FMF affects more than 100,000 people worldwide and generally seen in the eastern Mediterranean region and causes the lifelong diseases which have a significant effect on the patient's life quality and health systems. The identification of low penetrant or heterozygous MEFV gene mutations in clinically diagnosed FMF patients was considered that epigenetic or environmental factors may display a role in FMF pathogenesis. Epigenetics might be defined as heritable changes that affect gene expression without any changes in the genome. MicroRNAs (miRNAs) are the main group of small noncoding RNAs, and an important element of epigenetic mechanisms and their discoveries revolutionized our knowledge about biological processes, such as malignant, infectious and autoimmune mechanisms, and contributed to the development of the epigenetic areas. In this review, the studies focusing on the roles of miRNAs in FMF pathogenesis in the last decades were examined and the importance of miRNAs as therapeutic agents which are promising for diagnosis and treatment was discussed.
Lifestyle patterns in European preschoolers: Associations with socio‐demographic factors and body mass index
Authors: Descarpentrie Alexandra , Calas Lucinda , Cornet Maxime , Heude Barbara , Charles Marie‐Aline , Avraam Demetris , Brescianini Sonia , Cadman Tim , Elhakeem Ahmed , Fernández‐Barrés Sílvia , Harris Jennifer R. , Inskip Hazel , Julvez Jordi , Llop Sabrina , Margetaki Katerina , Maritano Silvia , Nader Johanna Lucia Thorbjornsrud , Roumeliotaki Theano , Salika Theodosia , Subiza‐Pérez Mikel , Vafeiadi Marina , Vrijheid Martine , Wright John , Yang Tiffany , Dargent‐Molina Patricia , Lioret Sandrine 
Published: October 2023

SummaryBackgroundEnergy balance‐related behaviours (EBRBs), that is, dietary intake, screen, outdoor play and sleep, tend to combine into ‘lifestyle patterns’, with potential synergistic influences on health. To date, studies addressing this theme mainly focused on school children and rarely accounted for sleep, with a cross‐country perspective.ObjectivesWe aimed at comparing lifestyle patterns among preschool‐aged children across Europe, their associations with socio‐demographic factors and their links with body mass index (BMI).MethodsHarmonized data on 2–5‐year‐olds participating in nine European birth cohorts from the EU Child Cohort Network were used (EBRBs, socio‐demographics and anthropometrics). Principal component analysis and multivariable linear and logistic regressions were performed.ResultsThe most consistent pattern identified across cohorts was defined by at least three of the following EBRBs: discretionary consumption, high screen time, low outdoor play time and low sleep duration. Consistently, children from low‐income households and born to mothers with low education level had higher scores on this pattern compared to their socioeconomically advantaged counterparts. Furthermore, it was associated with higher BMI z‐scores in the Spanish and Italian cohorts (β = 0.06, 95% CI = [0.02; 0.10], both studies).ConclusionThese findings may be valuable in informing early multi‐behavioural interventions aimed at reducing social inequalities in health at a European scale.
Controversies in terminology associated with management of BCG‐unresponsive NMIBC in Asia‐Pacific
Authors: Kikuchi Eiji , Ng Chi‐Fai , Kitamura Hiroshi , Ku Ja Hyeon , Lee Lui Shiong , Lin Tzu‐Ping , Ng Junice Yi Siu , Nishiyama Hiroyuki , Poon Darren Ming‐Chun , Kanesvaran Ravindran , Seo Ho Kyung , Spiteri Carmel , Tan Ee Min , Tsai Yuh‐Shyan , Tran Ben 
Published: October 2023

ObjectivesExamine the understanding of terminologies and management patterns of bacillus Calmette‐Guérin (BCG)‐unresponsive nonmuscle invasive bladder cancer (NMIBC) in six territories in Asia‐Pacific.MethodsThis study involved two phases: (1) a survey with 32 urologists and 7 medical oncologists (MOs) and (2) a factorial experiment and in‐depth interviews with 23 urologists and 2 MOs. All clinicians had ≥8 years' experience managing NMIBC patients in Australia, Hong Kong, Japan, South Korea, Singapore, and Taiwan. Data from Phase 1 were summarized using descriptive statistics; content and thematic analyses applied in Phase 2.ResultsIn phase 1, 35% of clinicians defined BCG‐unresponsive as BCG‐refractory, ‐relapse and ‐resistant, 6% defined it as BCG‐refractory and ‐relapse; 22% classified BCG‐failure as BCG‐refractory, ‐relapse, ‐resistant, and when muscle‐invasive bladder cancer is detected. If eligible and willing, 50% (interquartile range [IQR], 50%–80%) of BCG‐unresponsive patients would undergo radical cystectomy (RC), and 50% (IQR 20%–50%) of RC‐eligible patients would receive bladder‐sparing treatment or surveillance. In phase 2, we found that 32%, 88%, and 48% of clinicians, respectively, used “BCG‐unresponsive,” “BCG‐refractory,” and “BCG‐relapse” in clinical practice but with no consistent interpretation of the terms. Compared with EAU definitions, 8%–60% of clinicians appropriately classified 9 tumor types that are persistent or recurrent after adequate BCG. Fifty percent of clinicians mentioned a lack of bladder‐preserving treatment that outperforms RC in quality of life as a reason to retreat BCG‐unresponsive patients with BCG.ConclusionsOur study revealed varied understanding and application of BCG‐unresponsive terminologies in practice. There is a need for a uniform and simple definition of BCG‐unresponsive disease in Asia‐Pacific.
Long‐term stability (21–30 years) of root coverage outcomes using sub‐epithelial connective tissue grafts at single or multiple gingival recessions: A longitudinal case series
Authors: Bertoldi Carlo , Consolo Ugo , Lalla Michele , Zaffe Davide , Tanza Donato , Cairo Francesco , Cortellini Pierpaolo 
Published: October 2023

AbstractAimTo evaluate outcomes and predictive factors for the long‐term stability of root coverage using a sub‐epithelial connective tissue graft.Materials and MethodsOne‐hundred and two healthy subjects (221 gingival recessions, GRs) were treated from 1987 to 1996. Keratinized tissue width (KTW), GR depth (RD), GR width (RW) and GR area (RA) were evaluated at baseline (M0) and at 1 month (M1), 1 year (M2), 11 years (M3), 21 years (M4) and 27 years (M5) after surgery. Primary outcomes consisted of complete root coverage (cRC) and relative dimensional changes in recession depth (measured in mm [c%‐RD]), recession width (measured in mm [c%‐RW]) and recession area (measured in mm2 [c%‐RA]).ResultscRC was 88.7% at 1 year (M2), 59.8% at M3, 44.4% at M4 and 51.9% at M5. Average c%‐RD was 95.2% at 1 year, 81.9% at M3, 71.5% at M4 and 81.7% at M5. KTW increased after surgery and over time and was positively correlated with favourable outcomes. Increased baseline RA was associated with less favourable clinical outcomes.ConclusionsThe sub‐epithelial connective tissue graft is effective in the treatment of GRs and facilitates long‐term stability of clinical outcomes. Wider baseline RA was a strong predictor of unfavourable short‐ and long‐term RC outcomes.
Concurrent and prospective associations between family socioeconomic status, social support and salivary diurnal and hair cortisol in adolescence
Authors: Cantave Christina Y. , Brendgen Mara , Lupien Sonia , Dionne Ginette , Vitaro Frank , Boivin Michel , Ouellet‐Morin Isabelle 
Published: October 2023

BackgroundExposure to socioeconomic adversity is hypothesized to impact hypothalamic–pituitary–adrenal (HPA) axis activity and cortisol secretion, but existing evidence is inconsistent. Yet, few studies have investigated this association using a developmental approach that considers potential protective contextual factors. This study examined the role of stability and changes in family socioeconomic status (SES) in the prediction of multiple cortisol indicators and tested whether social support moderated these associations.MethodsParticipants were part of a population‐based sample of twin pairs recruited at birth. Family SES was assessed in early childhood (ages 0–5) and mid‐adolescence (age 14). Social support was assessed at ages 14 and 19. Diurnal cortisol (n = 569) was measured at age 14 at awakening, 30 min later, in the afternoon and evening over four non‐consecutive days. Hair cortisol concentration (HCC, n = 704) was measured at age 19. All data were collected before the pandemic and multilevel regression models were conducted to account for the nested data structure.ResultsYouth exposed to lower family SES levels in childhood and mid‐adolescence had a flatter diurnal slope and higher HCC compared with those who experienced upward socioeconomic mobility in mid‐adolescence. Contrastingly, mid‐adolescence SES showed no association with the diurnal slope or HCC for youth from higher‐SES households in early childhood. Moreover, youth raised in higher‐SES families in early childhood had a higher CAR in mid‐adolescence if they reported greater social support in mid‐adolescence. Social support also moderated the SES‐cortisol association in mid‐adolescence, with higher‐SES youth showing higher awakening cortisol secretion when reporting more social support.ConclusionsOur findings support the hypothesis that early socioeconomic adversity sensitizes HPA axis activity to later socioeconomic disadvantage, which may bear consequences for socioemotional and behavioral functioning.
Sympathetic skin response for early detection of type 2 diabetic peripheral neuropathy and nephropathy
Authors: Liu Hongying , Tan Sheng , Ma Zhenyu , Gao Qingchun , Yang Weihong 
Published: October 2023

ABSTRACTBackgroundDiabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN) are common complications of type 2 diabetes mellitus (T2DM). Although nerve conduction studies (NCS) and sympathetic skin response (SSR) can detect DPN, the more sensitive method for early diagnosis remains unclear. Furthermore, whether DPN can be used as a predictor for diabetic nephropathy needs clarification.MethodsWe evaluated nerve conduction studies, sympathetic skin response, and the diabetic nephropathy indicator microalbuminuria (MAU) in 192 patients with type 2 diabetes mellitus and 50 healthy controls.ResultsPatients with type 2 diabetes mellitus showed a lower sensory nerve conduction velocity (SCV), sensory active nerve potential (SNAP), motor nerve conduction velocity (MCV), and compound motor action potential (CMAP) than the controls on NCS. Abnormal rates for nerve conduction studies and sympathetic skin response were 75.0% and 83.3%, respectively, in patients with type 2 diabetes mellitus. Interestingly, 54.2% of patients with normal nerve conduction studies had an abnormal sympathetic skin response. Moreover, we found a positive correlation between sympathetic skin response and microalbuminuria for the first time. The abnormal rate of microalbuminuria was 53.8%, lower than that of abnormal nerve conduction studies or sympathetic skin response patients.ConclusionSympathetic skin response is a more sensitive method than nerve conduction studies for the early diagnosis of diabetic peripheral neuropathy. Abnormal sympathetic skin response might serve as an indicator for early diabetic nephropathy. Additionally, diabetic peripheral neuropathy may occur earlier than diabetic nephropathy in the development of type 2 diabetes mellitus.
Mass mortality events associated with cyprinid herpesvirus 2 (CyHV‐2) infection in wild Prussian carp Carassius gibelio in the Netherlands, and molecular biology of virus strains
Authors: Kurobe Tomofumi , Kurita Jun , Haenen Olga , Voorbergen‐Laarman Michal , Ito Takafumi 
Published: October 2023

AbstractIn 2011 and 2015, four mass mortalities of Prussian carp (Carassius gibelio) were observed in a recreational freshwater lake and open freshwater in the western part of the Netherlands. Cyprinid herpesvirus 2 (CyHV‐2) infection was suspected in these cases, based on presumptive gross diagnosis. To elucidate the cause of the mass mortalities diagnostic PCR assays were performed for CyHV‐2, based on the helicase gene. Furthermore, the viral isolates were genotyped by sequencing the enlarged marker A and marker B sequences. Diagnostic PCR revealed that three of four samples were positive for CyHV‐2, indicating these three mass mortalities were associated with CyHV‐2 infection. The marker A sequence from one of the isolates found in this study was identical to those from different locations such as Asia and Middle East, suggesting a link among the isolates. This is the first detailed report on mass mortalities of Prussian carp associated with CyHV‐2 infection in natural aquatic environments in the Netherlands. Since 2015, additionally, in total three CyHV‐2 associated outbreaks of Dutch Prussian carp were seen in 2016 and 2020. These outbreaks in Prussian carp from lakes and open water suggest that the virus has been spreading in natural freshwaters in the Netherlands.
Audit evidence, technology, and judgement: A review of the literature in response to ED‐500
Authors: Barr‐Pulliam Dereck , Calvin Christopher G. , Eulerich Marc , Maghakyan Arpine 
Published: October 2023

AbstractIn October 2022, the International Auditing and Assurance Standards Board (IAASB) issued Exposure Draft 500 (ED‐500). This is focused on revising and integrating the standard auditors use when evaluating audit evidence during an external audit. This study contributes to the ongoing discourse as the IAASB evaluates feedback to ED‐500 and executes its standard‐setting agenda. We review academic literature published in the past 10 years to synthesize extant knowledge specifically on the use of technology and the application of professional skepticism during audit evidence evaluation. Our review offers factors the IAASB should consider when seeking to modernize and future‐proof its standards, suggesting improvements to the proposed ED‐500. We also identify fruitful avenues for future academic research.
The multidimensional nature of career self‐management behaviours and their relation to facets of employability
Authors: Wilhelm Francisco , Hirschi Andreas , Schläpfer Dawa 
Published: October 2023

AbstractCareer self‐management (CSM) has attracted increased scholarly interest, but definitional issues and the lack of an integrative understanding constrain research on the topic. In two studies, we seek to clarify the nature and dimensionality of CSM behaviour, examine the relation of specific dimensions to the general construct and investigate the relation of different CSM behaviours to facets of employability. In Study 1, we used a systematic literature review and thematic analysis to identify seven key CSM behaviours: (a) impression management, (b) building contacts, (c) using contacts, (d) human capital development, (e) goal setting and planning, (f) self‐exploration and (g) mobility‐oriented behaviour. Across two samples in Study 2 (combined N = 1065), we examined the relation of the seven behaviours to the general CSM construct and their relation to facets of employability in a time‐lagged analysis. The results show that CSM behaviours are best modelled as a bifactor structure with a general dimension and seven specific behaviours. Specific CSM behaviours explained unique variance in specific facets of employability. In sum, the studies clarify our understanding of CSM's nature, dimensionality, structure, and nomological net.