bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model
Authors: Bodenlenz Manfred , Yeoh Thean , Berstein Gabriel , Mathew Shibin , Shah Jaymin , Banfield Christopher , Hollingshead Brett , Steyn Stefanus J. , Osgood Sarah M. , Beaumont Kevin , Kainz Sonja , Holeček Christian , Trausinger Gert , Raml Reingard , Birngruber Thomas 
Published: December 2023

Abstract
Purpose
Accurate methods to determine dermal pharmacokinetics are important to increase the rate of clinical success in topical drug development. We investigated in an in vivo pig model whether the unbound drug concentration in the interstitial fluid as determined by dermal open flow microperfusion (dOFM) is a more reliable measure of dermal exposure compared to dermal biopsies for seven prescription or investigational drugs. In addition, we verified standard dOFM measurement using a recirculation approach and compared dosing frequencies (QD versus BID) and dose strengths (high versus low drug concentrations).

Methods
Domestic pigs were topically administered seven different drugs twice daily in two studies. On day 7, drug exposures in the dermis were assessed in two ways: (1) dOFM provided the total and unbound drug concentrations in dermal interstitial fluid, and (2) clean punch biopsies after heat separation provided the total concentrations in the upper and lower dermis.

Results
dOFM showed sufficient intra-study precision to distinguish interstitial fluid concentrations between different drugs, dose frequencies and dose strengths, and had good reproducibility between studies. Biopsy concentrations showed much higher and more variable values. Standard dOFM measurements were consistent with values obtained with the recirculation approach.

Conclusions
dOFM pig model is a robust and reproducible method to directly determine topical drug concentration in dermal interstitial fluid. Dermal biopsies were a less reliable measure of dermal exposure due to possible contributions from drug bound to tissue and drug associated with skin appendages.
Instantaneous CO2 emission modelling for a Euro 6 start-stop vehicle based on portable emission measurement system data and artificial intelligence methods
Authors: Mądziel Maksymilian 
Published: December 2023

AbstractOne of the increasingly common methods to counteract the increased fuel consumption of vehicles is start-stop technology. This paper introduces a methodology which presents the process of measuring and creating a computational model of CO2 emissions using artificial intelligence techniques for a vehicle equipped with start-stop technology. The method requires only measurement data of velocity, acceleration of vehicle, and gradient of road to predict the emission of CO2. In this paper, three methods of machine learning techniques were analyzed, while the best prediction results are shown by the gradient boosting method. For the developed models, the results were validated using the coefficient of determination, the mean squared error, and based on visual evaluation of residual and instantaneous emission plots and CO2 emission maps. The developed models present a novel methodology and can be used for microscale environmental analysis.
Biostimulation of indigenous microbes for uranium bioremediation in former U mine water: multidisciplinary approach assessment
Authors: Newman-Portela Antonio M. , Krawczyk-Bärsch Evelyn , Lopez-Fernandez Margarita , Bok Frank , Kassahun Andrea , Drobot Björn , Steudtner Robin , Stumpf Thorsten , Raff Johannes , Merroun Mohamed L. 
Published: December 2023

AbstractCharacterizing uranium (U) mine water is necessary to understand and design an effective bioremediation strategy. In this study, water samples from two former U-mines in East Germany were analysed. The U and sulphate (SO42−) concentrations of Schlema-Alberoda mine water (U: 1 mg/L; SO42−: 335 mg/L) were 2 and 3 order of magnitude higher than those of the Pöhla sample (U: 0.01 mg/L; SO42−: 0.5 mg/L). U and SO42− seemed to influence the microbial diversity of the two water samples. Microbial diversity analysis identified U(VI)-reducing bacteria (e.g. Desulfurivibrio) and wood-degrading fungi (e.g. Cadophora) providing as electron donors for the growth of U-reducers. U-bioreduction experiments were performed to screen electron donors (glycerol, vanillic acid, and gluconic acid) for Schlema-Alberoda U-mine water bioremediation purpose. Thermodynamic speciation calculations show that under experimental conditions, U(VI) is not coordinated to the amended electron donors. Glycerol was the best-studied electron donor as it effectively removed 99% of soluble U, 95% of Fe, and 58% of SO42− from the mine water, probably by biostimulation of indigenous microbes. Vanillic acid removed 90% of U, and no U removal occurred using gluconic acid.
Effect of microplastic particles on the population growth rate and clearance rate of selected ciliates (Protista, Ciliophora)
Authors: Budziak Martyna , Fyda Janusz 
Published: December 2023

AbstractMicroplastics (MPs), due to their micro size, which overlaps with the typical food size of various aquatic organisms, can be ingested and move up the food chain, accumulating in the bodies of organisms at higher trophic levels. Few studies have focused on the uptake of MPs by ciliates, which are an important element of the microbial cycle. Three different ciliate species were used in this study: Blepharisma japonicum, Euplotes sp., and Spirostomum teres, as well as polystyrene beads with diameters of 1 and 2 µm at two concentrations (106 and 107 beads × mL−1). The results of the experiments showed that MPs have a variable, species-specific effect on the population growth rate of ciliates, which is directly dependent on their concentration in the environment (P < 0.01). It was also observed that the number of MPs ingested changed over time depending on their concentration and size. On average, the highest number of ingested MPs (883.11 ± 521.47) was recorded at 60 min of exposure to a low concentration of small beads in B. japonicum. The lowest number of beads was ingested after 5 min of exposure to a low concentration of large beads in the same species. The rate of MP uptake by the ciliate species was significantly dependent on their concentration, exposure time, and size (P < 0.001). The highest clearance rate was observed in the fifth minute of the experiment in the environment with the lowest MP concentration.
The cognitive reality of morphomes. Evidence from Italian
Authors: Cappellaro Chiara , Dumrukcic Nina , Fritz Isabella , Franzon Francesca , Maiden Martin 
Published: December 2023

AbstractThis study reports and discusses the results of a pilot psycholinguistic investigation into the morphome – a term created (Aronoff 1994) to indicate systematic relations between form and meaning in morphology which lack synchronic semantic, functional, or phonological determinants and are thereby purely morphological.Despite a general consensus (cf. Bermúdez-Otero and Luís 2016) on the need to approach the question of the existence and nature of morphomic structures experimentally and interdisciplinarily, there has been no study beyond Nevins, Rodrigues, and Tang (2015), which focused on the morphomic structure in Romance verb morphology identified by Maiden (1992) and labelled (arbitrarily) the ‘L-pattern’ and concluded that in Italian, Spanish and Portuguese this structure is no longer part of native speakers’ grammar.The present study has replicated, for Italian, the basic experimental design of Nevins et al. It has obtained behavioural measurements (from two experiments) including eyetracking measures (from one experiment). All these measurements converge in showing (i) a statistically significant preference for target items that are consistent with the L-/U-pattern distribution and (ii) a faster decision-making process when the L-item was chosen. We conclude that (pace Nevins et al.) this morphomic structure is part of the internalized grammar of Italian adult speakers.
Die partizipative Methode Photovoice im Kontext Gesundheitsförderung
Authors: Trompke Michaela , Götz Madlen , Dieudonné Jessica , Jantzen Lisa , Sanwald Michelle , Gehrmann Jan 
Published: December 2023

Zusammenfassung
Hintergrund
Im Rahmen eines hochschulinternen Seminars wurden Photovoice-Studien von Studierenden geplant, durchgeführt und ausgewertet. Die Studien befassten sich mit dem Verständnis von Gesundheitsförderung im Alltag von Studierenden aus physischer, psychischer und sozialer Perspektive. Das Ziel des Projekts war die Anwendung der Methode und die kritische Reflexion dieser im Kontext der Chancen und Herausforderungen partizipativer Ansätze.

Methode
In Kleingruppen wurden 3 Photovoice-Studien durchgeführt. Die Identifizierung der Forschungsfragen erfolgte in einem partizipativen Prozess. Daran wurde eine einwöchige Feldphase angeschlossen, in der Fotos zu den jeweiligen Fragestellungen aufgenommen wurden. Nach der Feldphase folgten die Diskussion sowie die Auswertung der Ergebnisse in den Kleingruppen. Die Anwendung der Methode wurde abschließend reflektiert.

Projektbeschreibung
Die Teilstudien fokussierten die Themenbereiche Stressmanagement, Bewegung und Freundschaft. Im Rahmen dieses Artikels werden die Umsetzungsphasen der Methode Photovoice dargestellt. Die Realisierung der Teilstudien erfolgte anhand von sieben Umsetzungsphasen. Die Darstellung der Ergebnisse fokussiert sich primär auf die Planung, Umsetzung und Reflexion des Gesamtprojekts.

Reflexion
Die Anwendung der partizipativen Methode Photovoice förderte durch den stattfindenden Austausch die Auseinandersetzung mit den thematisierten Untersuchungsgegenständen. Die Umsetzung des gesamten Projekts führte zu einer Selbstreflexion über mögliche Forschungs- und Praxisansätze.

Schlussfolgerung
Photovoice als partizipative Forschungsmethode bietet die Möglichkeit, Menschen in ihren Lebenswelten zu erreichen. Wichtig ist dabei die transparente Arbeitsweise aller Forschenden und Beteiligten. Für einen umfassenderen inhaltlichen Einblick sollte sich die Feldphase in ähnlichen Projektvorhaben über einen längeren Zeitraum erstrecken.
New composite materials based on reduced graphite oxide for electrochemical sorption of hydrogen and methanol electrooxidation
Authors: Rozmanowski Tomasz , Krawczyk Piotr , Gurzęda Bartosz , Ratajczyk Kornelia 
Published: December 2023

AbstractThe present work describes preparation of the reduced graphite oxide/nickel/palladium (rGO/Ni/Pd) composite and the examination of its basic electrochemical properties. The reduced graphite oxide was prepared by thermal reduction of graphite oxide beforehand obtained by electrochemical overoxidation of graphite in 8 M HClO4. In the second stage, Ni particles were electrodeposited onto rGO by the galvanostatic method. Finally, chemical deposition of palladium catalyst was performed to yield rGO/Ni/Pd composite. Transmission electron microscopy analysis (TEM) along with energy dispersive spectroscopy (EDS) technique has been used to determine the size as well as the distribution of Ni and Pd particles. The acquired electrochemical results revealed that rGO/Ni/Pd composite exhibits a good activity towards the processes of electrosorption of hydrogen. The highest calculated H/Pd atomic ratio for rGO/Ni/Pd electrode was equal 0.62. Electrocatalytic activity of the investigated material is also depicted by the reaction of methanol electrooxidation. Recorded current density of methanol electrooxidation was 15.04 A g−1 Pd.
Effects of acupuncture and moxibustion on UHRF1 and DNMT1 in ectopic endometrium of rats with endometriosis
Authors: Li Mingyang , Wang Yanwen , Shao Yanting , Sun Yichun , Hu Jiawei , Gao Yuan , Li Yuran , Wu Chuting , Zhang Chunyan 
Published: December 2023

Abstract
Objective
To observe the effects of acupuncture and moxibustion on ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) and DNA methyltransferase 1 (DNMT1) in ectopic endometrium of rats with endometriosis (EMS).

Methods
Forty Sprague-Dawley rats were randomly divided into a sham operation group with 10 rats and a model-building group with 30 rats according to body mass. EMS rat models were established in the model-building group and then were divided into a model group, an acupuncture and moxibustion group, and a progesterone group, with 10 rats in each group. All rats were fixed by a fixator. The sham operation group and the model group were given normal saline by gavage. The acupuncture and moxibustion group received acupuncture at Xuehai (SP10) and Sanyinjiao (SP6), moxibustion at Guanyuan (CV4), and gavage of normal saline. The progesterone group was given the mixed liquid made of dydrogesterone and normal saline by gavage. After 28 d of treatments, the three diameters (length, width, and height) of EMS rats’ ectopic cysts were measured, the cyst volumes were calculated, the volumes before intervention were subtracted, and the difference values were used to evaluate the growth of ectopic cysts. UHRF1 and DNMT1 mRNA and protein levels in normal endometrium, eutopic endometrium, and ectopic endometrium were detected by real-time polymerase chain reaction and immunohistochemistry.

Results
There was no significant difference in the ectopic cyst volume difference between the acupuncture and moxibustion group and the progesterone group (P>0.05), but they were smaller than that of the model group (P<0.05). The levels of UHRF1 and DNMT1 mRNA and protein in the ectopic endometrium of the model group were lower than those in the normal endometrium (P<0.05). The levels of DNMT1 mRNA and UHRF1 protein in the eutopic endometrium of the model group were lower than those in the normal endometrium (P<0.05). The levels of UHRF1 mRNA and protein and the level of DNMT1 protein in the ectopic endometrium of the acupuncture and moxibustion group were higher than those in the model group (P<0.05), and the level of UHRF1 mRNA was higher than that in the progesterone group (P<0.05). The level of DNMT1 mRNA in the eutopic endometrium of the acupuncture and moxibustion group was higher than that in the model group (P<0.05). The levels of UHRF1 and DNMT1 mRNA and protein in the acupuncture and moxibustion group were insignificantly different from those in the normal endometrium (P>0.05).

Conclusion
Acupuncture and moxibustion may up-regulate the levels of UHRF1 mRNA and UHRF1 and DNMT1 proteins in the ectopic endometrium to the normal level so as to reduce the volume of ectopic cysts and cure endometriosis in rats.
Application of Two-dimensional P-type ZnO Powder Illuminated By Visible Light for the Inhibition of Gram-positive and Gram-negative Bacteria in Water
Authors: Díaz-Gómez C. , Carrillo-Morales M. , Zagal-Padilla C. K. , Masegosa-Méndez H. , Gamboa S. A. 
Published: December 2023

AbstractBacteria affect food quality in developing countries by spreading through contaminated soils and water. Antibiotics are used indiscriminately to eliminate Gram-positive and Gram-negative bacteria, with varying degrees of success. The use of nanomaterials with bactericidal properties can minimize the overuse of antibiotics. In this study, a two-dimensional p-type ZnO powder was successfully synthesized and its bactericidal properties were demonstrated. The XRD and Raman spectroscopy results indicated the presence of wurtzite-phase ZnO with Oi as the predominant native defect, resulting in p-type conductivity. SEM analysis confirmed the two-dimensional morphology, and optoelectronic characterization revealed a bandgap of 3.17 eV. Despite this high bandgap value, a plasmonic effect was generated on the surface of two-dimensional ZnO, which enhanced its bactericidal properties when the powders were in contact with bacteria. From an initial colony level of 5.5 × 105 CFU/mL, a significant decrease in the number of Gram-positive bacteria to 1.15 × 105 CFU/mL was observed, whereas the number of Gram-negative bacteria slightly increased to 1.45 × 106 CFU/mL. The observed inhibition rates were higher than those achieved with the broad-spectrum antibiotic, as validated in this study. The use of two-dimensional ZnO may provide a sustainable solution for the eradication of waterborne pathogens using visible light alone.
A taxonomy of critical factors towards sustainable operations and supply chain management 4.0 in developing countries
Authors: Caiado Rodrigo Goyannes Gusmão , Scavarda Luiz Felipe , Vidal Guilherme , de Mattos Nascimento Daniel Luiz , Garza-Reyes Jose Arturo 
Published: December 2023

AbstractSupply chain disruptions, intensified by black swan events such as the COVID-19 pandemic and the Russia-Ukraine war, have increased the interest in resilient supply chains, which can be achieved by adopting sustainable Industry 4.0 (I4.0) practices. However, the critical success factors (CSFs) for sustainable I4.0 in operations and supply chain management (S-OSCM4.0) are unclear, and there is a lack of a holistic and empirically validated taxonomy of CSFs from multiple stakeholders' perspectives to guide organizations in this transition. Moreover, developing countries face specific challenges that require prioritizing the proper set of CSFs for sustainable digitalization. Therefore, this paper aims to develop a CSFs-based taxonomy for S-OSCM4.0 to help organizations stay current in I4.0 adoption and integrate sustainability in OSCM. We first conducted a systematic literature review (SLR) of 131 papers using bibliometric and content analyses and synthesized the theoretical findings into an alpha taxonomy of CSFs following an inductive approach. Then, we employed a Delphi survey technique combining fuzzy logic to solicit experts' perceptions from a developing country to analyze and validate the taxonomy and determine the most pertinent CSFs, resulting in a beta taxonomy of CSFs for S-OSCM4.0. The developed taxonomy represents a pioneering managerial artefact that can guide sustainable development through an inclusive digital transformation with less environmental impact, contributing to decision-making in S-OSCM4.0, especially for operations in developing countries.
Some Inequalities for the Fourier Transform and Their Limiting Behaviour
Authors: Garofalo Nicola 
Published: December 2023

AbstractWe identify a one-parameter family of inequalities for the Fourier transform whose limiting case is the restriction conjecture for the sphere. Using Stein’s method of complex interpolation, we prove the conjectured inequalities when the target space is $$L^2$$

L
2

, and show that this recovers in the limit the celebrated Tomas-Stein theorem.
A taxonomic revision of the genus Weberbauerella Ulbr. (Leguminosae: Papilionoideae) in Peru and Chile
Authors: Orellana-Garcia A. , Hechenleitner P. , Whaley O. Q. , Capcha-Ramos J. , Moat J. , Lewis G. P. 
Published: December 2023

SummaryThe little-known and infrequently collected papilionoid legume genus Weberbauerella, is only known from outlying regions of the Atacama Desert. Presently it comprises three species, one in Chile and two in Peru. These small, woody, perennial species, enigmatic in both occurrence and form, are found growing in isolated populations in climatically extreme conditions. They are characterised by the presence of pustular glands throughout. Here we revise the genus, providing a key to the species, descriptions, distribution maps, illustrations, assessments of conservation status and notes on a northern variant population.
Upper-GI highlights from ASCO and ASCO-GI 2023 meetings: changing paradigm in treatment sequence
Authors: Ilhan-Mutlu Aysegül , Bergen Elisabeth Sophie 
Published: December 2023

SummaryThe annual meeting of the American Society of Medical Oncology (ASCO) was held as usual in Chicago, while the meeting focused on gastrointestinal tumors, ASCO-GI, was held in San Francisco. In particular, ASCO-GI included many phase III trials, the data of which have the potential to change the practice in the near future for tumors of the upper gastrointestinal tract (upper-GI), including tumors of the esophagus, gastroesophageal junction, stomach, and pancreas. Interestingly, ASCO and also the European Society for Medical Oncology (ESMO) offer the virtual plenary sessions under the motto “Today’s Science Can Wait.” As more physicians and scientists become comfortable with online tools in the post-pandemic era, presenting potential practice-changing data outside of annual meetings appears feasible. Here we present a summary of upper-GI tumor abstracts from two major ASCO meetings including virtual plenary series.
Does Cultural Robotics Need Culture? Conceptual Fragmentation and the Problems of Merging Culture with Robot Design
Authors: Mansouri Masoumeh , Taylor Henry 
Published: December 2023

AbstractIncreasingly, roboticists have to pay attention to cultural norms and expectations. But roboticists have generally worked with a relatively narrow understanding of culture, based on nationality. This contrasts with the rich and diverse understandings of culture from disciplines as diverse as sociology, philosophy, and anthropology. Here we draw on the philosophy of science literature on scientific terminology to argue that culture is aconceptually fragmentedconcept: the concept has no unified definition, and alternative definitions of culture are useful for different areas within robotics. We argue that this has important implications for robotics. We consider two possible reactions to this situation. One claims that, despite the lack of a unified definition, the concept of culture still fulfils useful roles within robotics, and ought to be preserved. The other argues that the problems with the concept are so great that the concept ought to be eliminated from discussions in robotics. We argue in favour of the former option.
How can population models contribute to contemporary pest management practices?
Authors: Yamanaka Takehiko 
Published: December 2023

AbstractPopulation models provide a logical knowledge base before conducting laborious and expensive field experiments. Historically, two types of population models have been developed: highly realistic simulations and simple analytical models. Highly realistic simulations comprise a complicated systems model, whereas simple analytical models comprise various analytical models that focus only on the fundamental structure of the target pest population. Although both approaches have contributed to pest management science, each has limitations, poor predictability, and lacks substantial connections to reality. Assimilation by state-space modeling, in which observation and process models are jointly incorporated, is a good compromise between a simple model and reality in nature. In the big data era, artificial intelligence (AI), specifically aimed at high predictability, has recently become popular. If vital physical and biological records are automatically censored in the field with high precision, AI will produce the most plausible predictions, providing the best practical solution given our current knowledge. AI can be a powerful tool in the contemporary world; however, deductive modeling approaches are still important when considering the behavior of AIs and may also provide important insights to detect deficient information in the data.
Digitalisierung und Regulierung am Arbeitsmarkt
Authors: Weber Enzo 
Published: December 2023

ZusammenfassungIndustrie 4.0 und künstliche Intelligenz stehen in der Agenda der Debatte um die Zukunft des Arbeitsmarkts seit Jahren an erster Stelle. Die Corona-Krise hat der Digitalisierung im Arbeitsleben nochmals einen plötzlichen Schub gegeben. Die Transformation der Wirtschaft und die Weiterentwicklung von Sozialstaat und Arbeitsgesellschaft stellen die entscheidenden Herausforderungen dar. Dieser Artikel diskutiert einige Kernfragen und politische Gestaltungmöglichkeiten: Grundeinkommen, Weiterbildungspolitik, Robotersteuern und soziale Sicherung.