bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the performance of Inconel 718 ultrasonic vibration-assisted short electric arc milling composite machining
Authors: Ding Shengwei , Zhou Jianping , Wang Bingbing , Wang Zijian , Zhou Bisheng 
Published: November 2023

Abstract
A new method of ultrasonic vibration-assisted short electric arc machining is proposed to improve the machining quality of workpieces in response to abnormal discharge phenomena such as short circuits, partial discharge, and secondary discharge caused by particle bridges formed between electrodes and workpieces due to poor chip removal in ordinary short electric arc machining. After regular short electric arc and composite processing, the workpiece's macroscopic characteristics and microscopic morphology were compared through experiments. After processing, the surface morphology, roughness, and elemental energy spectrum were detected and analyzed using ultra-depth field, electron scanning, and other methods. The results showed that the surface morphology of the workpiece after the coupling of two particular machining technologies changed, and the surface patterns showed disorder and uniformity under ultrasonic action. The number of electrical corrosion pits and surface microcracks significantly decreased, the thickness of the recast layer decreased by more than twice, and the surface roughness decreased by more than 16%, with a maximum reduction of more than twice. At the same time, the surface elements of the material were modified. This provides a new approach for developing short electric arc technology to improve processing quality, material modification, and technological coupling.
Association between systemic inflammatory response index and abdominal aortic calcification
Authors: Shen Yishi , Zhou Shujing , Wu Chuhan , Huang Xufeng 
Published: November 2023

Abstract
Background
Systemic inflammatory response index (SIRI), a valuable marker which indicates the inflammatory condition in the human body, has drawn more attention recently. Nevertheless, the correlation between SIRI and abdominal aortic calcification (AAC) has never been reported. The aim of this study was to explore the association between SIRI and AAC.
Methods
We utilized cross-sectional data sourced from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) in this study. Multivariable linear regression models were employed to investigate the independent association between AAC and SIRI. Interaction test and subgroup analysis were conducted as well. Fitted smoothing curves were also applied to depict the nonlinear relationship.
Results
3047 representative participants > 40 years of age were included in this study. Those in the higher quartile of SIRI demonstrated a tendency toward higher mean AAC scores and an elevated risk of severe AAC. A positive correlation emerged between SIRI and ACC scores, as well as the risk of severe AAC (β = 0.18, 95% CI 0.01–0.35; OR = 1.23, 95% CI 1.01–1.51) in the fully adjusted model. No significant dependence on the correlation of SIRI and AAC was revealed by the subgroup analysis and interaction tests.
Conclusion
Our investigation revealed a positive association between SIRI and AAC. This suggests that SIRI could be a potential clinical marker for identifying the presence and severity of AAC.
Development and implementation of a novel split-wise model to predict the cutting forces in milling of Al2024 for minimum error
Authors: Heitz Thomas , He Ning , Jamil Muhammad , Bachrathy Daniel 
Published: November 2023

Abstract

This research study is devoted to propose a newly developed split-wise model to predict the cutting forces. The proof-of-the-study is achieved by implementing this model in milling Al2024 for the minimum error. The developed model is based on the classical shifted linear model used in the published literature. This model includes the calculation of the milling tool considering individual teeth, which leads to the determination of 6 force coefficients of different values per tooth. The experiments were conducted on milling Al2024 for two set of experiments (Vfz = 375-675 m/min, ae = 4-12 mm, ap = 0.5-1 mm, D =16 mm) and (Vfz = 220-440 m/min, ae = 0.5- 1 mm, ap = 0.5-1mm, D =2 mm). For the first set, the comparative error determined from the split-wise and classic models is 5.6% and 7.8%, respectively. For the second set, the error is 11% and 15.7%, respectively. Therefore, the use of the split-wise model is highly recommended for the prediction of the cutting force at low tool diameters. The study findings have shown the great capacity of the model to adapt to the runout, especially at low-scale milling where the spindle runout is amplified. Currently, the proposed study uses the optimal force coefficients, which were minimized via a cost function process.
pysentimiento: A Python Toolkit for Opinion Mining and Social NLP tasks
Authors: Perez Juan Manuel , Rajngewerc Mariela , Giudici Juan Carlos , Furman Damián Ariel , Luque Franco , Alemany Laura Alonso , Martínez María Vanina 
Published: November 2023

Abstract
In recent years, the extraction of opinions and information from user-generated text has attracted a lot of interest, largely due to the unprecedented volume of content in Social Media. However, social researchers face some issues in adopting cutting-edge tools for these tasks, as they are usually behind commercial APIs, unavailable for other languages than English, or very complex to use for non-experts. To address these issues, we present pysentimiento, a comprehensive multilingual Python toolkit designed for opinion mining and other Social NLP tasks. This open-source library brings state-of-the-art models for Spanish, English, Italian, and Portuguese in an easy-to-use Python library, allowing researchers to leverage these techniques. We present a comprehensive assessment of performance for several pre-trained language models across a variety of tasks, languages, and datasets, including an evaluation of fairness in the results.
Evaluation of GLOBE and UK-PBC Scores and Long- Term Outcomes in Primary Biliary Cholangitis Complicated with CREST Syndrome
Authors: Abe Kazumichi , Hayashi Manabu , Sugaya Tatsuro , Abe Naoto , Takahata Yosuke , Fujita Masashi , Takahashi Atsushi , Migita Kiyoshi , Ohira Hiromasa 
Published: November 2023

Abstract
Aim
Primary biliary cholangitis (PBC) is frequently associated with autoimmune disease. Although there have been some reports of PBC complicated with CREST syndrome (PBC-CREST), the long-term prognosis of these patients has not been fully investigated. Herein, the long-term prognosis of PBC-CREST was compared with that of PBC alone using GLOBE and UK-PBC scores.
Methods
A total of 302 patients diagnosed with PBC between December 1990 and August 2021 at our hospital and related institutions were included. The survival rates without liver transplantation (LT) were compared between patients with PBC-CREST (n = 57) and those with PBC alone (n = 245). Moreover, 173 patients were divided into two groups (PBC-CREST (n = 26) and PBC alone (n = 147)), excluding those with LT/liver-related death within 1 year after ursodeoxycholic acid administration; GLOBE and UK-PBC scores were compared.
Results
The survival rates without LT (3/5/10 years) were 98%/96%/96% for the PBC-CREST group and 92%/87%/80% for the PBC-alone group, with a significantly better prognosis in the PBC-CREST group (log-rank, P = 0.0172). The predicted liver-related death and LT risk (5/10/15 years) based on the UK-PBC score was significantly lower in the PBC-CREST group (2.4%/7.6%/13.2%) than in the PBC-alone group (4.8%/11.8%/18.8%; P < 0.05). The predicted LT-free survival (3/5 years) based on the GLOBE score was significantly higher in the PBC-CREST group (93%/88%) than in the PBC-alone group (88%/81%; P < 0.05). Multivariate analysis revealed that the presence of CREST syndrome is an independent protective factor for the presence of cirrhosis.
Conclusions
PBC-CREST may have a better long-term prognosis than PBC alone.
Fibroblast growth factor-18 promotes chondrocyte differentiation and plays a protective role in osteoarthritis
Authors: Li Jiayi , Zuo Jianhong 
Published: November 2023

Abstract
Background
Fibroblast growth factor18 (FGF18) is a synthetic growth factor that is associated with osteogenesis, chondrogenesis and articular cartilage repair. However, the exact mechanism is still unknown. In this work, we investigated the specific effects of FGF18 on chondrocyte differentiation and osteoarthritis (OA) development.
Methods
Recombinant FGF18 adenovirus (Ad-FGF18) was constructed to achieve instantaneous efficient expression. Chondrocyte progenitor cells were infected with Ad-FGF18 and subjected to chondrocyte differentiation. Alcian blue staining and chondrocyte differentiation markers’ qRT-PCR were used to evaluate the status of chondrocyte differentiation. Destabilization of the medial meniscus (DMM) surgery was used to construct the OA model. Ad-GFP or Ad-FGF18 was intra-articular injected once a week for 6 weeks. The knee joints were harvested for histological examination.
Results
FGF18 promoted chondrocyte differentiation by increasing the expression of Sox6, Col2 (Collagen type Ⅱ) and Acan (Aggrecan). In the knee joint of Ad-FGF18 intra-articular injected, there was little cartilage degradation, increased protein levels of COL2 and ACAN, and decreased protein levels of ADAMTS5 (a disintegrin and metallopeptidase with thrombospondin type 1 motif 5) and MMP13 (matrix metalloproteinase 13).
Conclusions
Our findings reveal that FGF18 promotes the differentiation of chondrocytes and protects articular cartilage from degradation during OA development. This finding provides a potential novel therapeutic approach for cartilage regeneration and treatment of osteoarthritis.
Rosai-Dorfman Disease Manifesting as a Solitary Mass With Fat in the Thymus
Authors: Liu Dan , Liu Xia , Liu Yi Sha , Zhou Chao Xin 
Published: November 2023

Abstract
Background
Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease, is a rare, self-limiting disease predominantly affects children and young adults. Moreover, the disease is characterized by painless bilateral cervical lymphadenopathy in 95% of the patients. However, few reports are available on the Rosai-Dorfman disease of the thymus.
Case presentation:
We report a rare case of thymic Rosai-Dorfman disease detected using computed tomography. During a medical examination, a 50-year-old man underwent a chest computed tomography scan, which revealed an anterior mediastinal single mass with fat in the thymus. A thymectomy was performed to completely remove the tumor using a thoracoscopic technique due to a clinical suspicion of thymoma. Furthermore, Rosai-Dorfman disease was confirmed using histological and immunohistochemical analyses.
Conclusions
To the best of our knowledge, this is the sixth case of thymus-affecting solitary Rosai-Dorfman disease with histological and immunohistochemical evidence. Fat in the thymus, as was present in this case, has never been described in Rosai-Dorfman disease previously. Our results highlight the challenge of diagnosing this uncommon tumor before surgery, and more cases need to be reported to help with the preoperative diagnosis of such a rare tumor.
Variation of the Vibrational Treatment on Mechanical Properties and Weld Residual Stress
Authors: Serrati Douglas Silva Marques , Silva Ricardo Martins , de Souza Daniel Dominices Baía Gomes , Wiezel Jonas Guilherme Gomes , Cunha Danilo Batista da , Araújo Douglas Bezerra , Vilarinho Louriel Oliveira 
Published: November 2023

Abstract
There are several ways to relieve welding residual stresses. The most commonly used and the only standardized method is the post weld heat treatment. However, this method is time-consuming and costly, which necessitates exploring other approaches that can ensure satisfactory results in a faster and more economical manner. In this context, relief of residual stresses through vibration has been gradually adopted by the industry. Therefore, this study aims to relieve welding residual stresses in thick plates to evaluate whether the position of the excitation source, whether parallel or coincident with the welded plates, influences the expected results. Additionally, it seeks to determine whether the best results are obtained when vibration stress relief is performed simultaneously with welding or after the completion of the process. Furthermore, the results of residual stress measurements using the blind-hole method are provided, and mechanical tests are conducted to determine the influence of these processes on mechanical properties. The results indicated that vibration performed after welding is more efficient and the position of the vibration motor has a significant influence on the results. Furthermore, it was observed that the stress relief process only impacted toughness, without significantly altering other mechanical properties.
125I brachytherapy as consolidative local therapy for patients with synchonous oligometastatic non-small cell lung cancer without progression after first-line chemotherapy plus PD-1 inhibitors treatment：A retrospective observational study
Authors: Meng Wang , Du Kepu , Li Shuai , Li Yadan , Gao Fei , Gao Mengyu , Chen Yanlin , Zhu Meiju , Zhou Zhigang 
Published: November 2023

Abstract
Purpose The aim was to investigate the safety and efficacy of 125I brachytherapy as consolidative local therapy for patients with synchonous oligometastatic non-small cell lung cancer (sOM-NSCLC) without progression after first-line chemotherapy plus PD-1 inhibitors treatment consolidative percutaneous.
Materials and Methods We retrospective analyzed 38 patients (31 male [81.6%], 7 women [18.4%], median age 66 years,range:[47-77 years] ) with sOM-NSCLC without epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) genetic aberrations, who were treated with first-line chemotherapy plus PD-1inhibitors 4-6 cycles followed by consolidative CT-guided 125I brachytherapy and maintenance therapy with PD-1 inhibitors in our hospital between June 2020 to June 2022 . Treatment efficacy and adverse events were evaluated.
Results At the cutoff date of December 2022, the median follow-up time was 16.5 months (range: 7-28 months). 26 patients had progressive disease (PD) and 6 patients had died, the median progression free survival (mPFS) was 17.0 months (95% CI, 12.0-22.0 months). 1 patient had complete response (CR), 26 patients had partial response (PR), 10 patients had stable disease (SD), 1 patient had progressive disease (PD). The best objective response rate (ORR) was 71.1%. Patients with PD-L1 positive cancers and 1-3 metastatic lesions had longer PFS than patients with PD-L1 negative and 4-5 metastatic lesions (18.0 months vs 12 months, p=0.038) and (17.0 months vs 9 months, p=0.010 ). The lymph node stage was an independent prognostic factor for PFS (19 months vs 9 months, p=0.002).
Conclusion 125I brachytherapy is a safe, feasible and valuable consolidative treatment for consideration in patients with sOM-NSCLC after first line chemotherapy plus PD-1 inhibitors treatment.
Robot-assisted laparoscopic continent cutaneous urinary diversion in a single- center study; surgical technique and outcomes
Authors: Loubersac Thomas , Lavallée Etienne , Reiss Benedicte , Lefort Marc , Kieny Pierre , Leclair Marc-David , Rigaud Jérôme , Normand Loic Le , Perrouin-Verbe Brigitte , Lefevre Chloe , Perrouin-Verbe Marie-aimée 
Published: November 2023

Abstract
Introduction:
Robot assisted laparoscopic cutaneous continent urinary diversion (RALCCUD) has been shown to be feasible; however, data on clinical outcomes in adults are lacking.
Materials & Methods:
We conducted a retrospective study of all adults who underwent RALCCUD between 2017 and 2022 at a single tertiary reference center.
Participant characteristics, clinical information and perioperative outcomes were recorded. All participants underwent pre and postoperative urodynamic evaluations.
Functional outcomes were evaluated at 3 months, then yearly. Continence was defined as no stomal or urethral leakage.
Results:
Twelve patients, mostly women (n=11), median (IQR) age 47.4 (19-57) years underwent RALCCUD (4 Mitrofanoff, 4 Yang-Monti and 4 Casale). The main indication for surgery was inability to perform intermittent self-catheterization through the native urethra.
Eleven patients (92%) had neurogenic lower urinary tract disease caused by spinal cord injury or spinal dysraphism.
Median (IQR) operative time was 313 (285-367) min. Four patients (33%) underwent concomitant procedures: 3 supra-trigonal cystectomy with augmentation cystoplasty and 1 artificial urinary sphincter. No conversions to an open approach were required. Median (IQR) follow-up was 42.9 (34-53) months. One early postoperative complication occurred (Clavien grade III). The late postoperative complication rate was 17%, with 3 complications occurring in 2 patients.
At the last follow up, all patients could self-catheterize through the tube, and the stomal and urethral continence rate was 100%.
Conclusion:
RALCCUD is feasible and safe in adults, with a high rate of stomal and urethral continence and a low complication rate.
NK cell-triggered CCL5/IFNγ-CXCL9/10 axis underlies the clinical efficacy of neoadjuvant anti-HER2 antibodies in breast cancer.
Authors: Santana-Hernández Sara , Suarez-Olmos Jesús , Servitja Sonia , Berenguer-Molins Pau , Costa-Garcia Marcel , Comerma Laura , Rea Anna , Perera-Bel Julia , menendez Slvia , Arpí Oriol , Bermejo Begoña , Cejalvo Juan Miguel , Martínez Maria Teresa , Comino-Mendez Iñaki , Pascual Javier , Alba Emilio , López-Botet Miguel , Rojo Federico , Albanell Joan , Rovira Ana , Muntasell Aura 
Published: November 2023

Abstract
Background
The variability in responses to neoadjuvant treatment with anti-HER2 antibodies prompts to personalized clinical management and the development of innovative treatment strategies. Tumor-infiltrating natural killer (TI-NK) cells can predict the efficacy of HER2-targeted antibodies independently from clinicopathological factors in primary HER2-positive breast cancer patients. Understanding the mechanism/s underlying this association would contribute to optimizing patient stratification and provide the rationale for combinatorial approaches with immunotherapy.
Methods
We sought to uncover processes enriched in NK cell-infiltrated tumors as compared to NK cell-desert tumors by microarray analysis. Findings were validated in clinical trial-derived transcriptomic data. In vitro and in vivo preclinical models were used for mechanistic studies. Findings were analysed in clinical samples (tumor and serum) from breast cancer patients.
Results
NK cell-infiltrated tumors were enriched in CCL5/IFNG-CXCL9/10 transcripts. In multivariate logistic regression analysis, IFNG levels underlie the association between TI-NK cells and pathological complete response to neoadjuvant treatment with trastuzumab. Mechanistically, the production of IFN-ɣ by CD16 + NK cells triggered the secretion of CXCL9/10 from cancer cells. This effect was associated to tumor growth control and the conversion of CD16 + into CD16-CD103 + NK cells in humanized in vivo models. In human breast tumors, the CD16 and CD103 markers identified lineage-related NK cell subpopulations capable of producing CCL5 and IFN-ɣ, which correlated with tissue-resident CD8 + T cells. Finally, an early increase in serum CCL5/CXCL9 levels identified patients with NK cell-rich tumors showing good responses to anti-HER2 antibody-based neoadjuvant treatment.
Conclusions
This study identifies specialized NK cell subsets as the source of IFN-ɣ influencing the clinical efficacy of anti-HER2 antibodies. It also reveals the potential of serum CCL5/CXCL9 as biomarkers for identifying patients with NK cell-rich tumors and favorable responses to anti-HER2 antibody-based neoadjuvant treatment.
A mutation in CACNA1F gene found by Whole Exome Sequencing (WES) and in silico analysis in an Iranian family with consanguineous relationships
Authors: Omarmeli Vahid , Sharafshah Alireza , Levandrowski Kai-Uwe , Faizmahdavi Hanieh , Darabi Parichehr , Amiri Amir , Assefi Marjan , Mansouri Nasrin 
Published: November 2023

Abstract
During a premarital study of a family-related couple, some exonic mutations in different genes under autosomal recessive and X-linked genetic inheritances were observed in the female case. After genetic counseling, DNA was extracted from the blood of the men and women, and then the Whole Exome Sequencing (WES) technique was used to look for possible pathogenic mutations in the two individuals. Also, after drawing the couple's pedigree, candidate mutations were examined in the woman's parents as well as her uncles. For further investigations, in silico analyses were performed through SWISS-MODEL, MolProbity, ProSA, PyMol, and FATCAT tools. The most important mutation which was diagnosed in the woman (R1362Q mutation in the 35th exon of CACNA1F), was observed in her mother and her two uncles. The mutation was also screened in both her father and her fiancé, but they had no mutations. After medical examinations of carriers, there was no sign of any eye impairment. Other mutations were TCTN2 (c.1613-2A > G), TARS (p.K319E), SPEG (p.E3020K), CPS1 (p.A1180V), MYO3A (p.I736M), NNT (p.R968Q), MED23 (p.K406T). Bioinformatics analyses indicated no alteration in the mutant structure of CACNA1F (Q1362) compared with the normal structure (R1362). Conclusively, the current study emphasizes the non-pathogenic effect of missense mutation R1362Q in the 35th exon of CACNA1F in association with ocular diseases. This will ensure the reports of this mutation as healthy instead of uncertain in the literature and databanks.
Exploring EFL Teachers' Perceptions Towards Implementing Task-Based Language Teaching in Teaching Grammar in Abu Dhabi/UAE
Authors: Abidi Suzan Al , Alabedi Farah , Bouzenoun Abdeldjalil , Owais Amjad , Zaitoun Eman 
Published: November 2023

Abstract
This qualitative case study was conducted in two private schools in Abu Dhabi/United Arab Emirates to explore EFL teachers’ perceptions of the effectiveness of implementing Task-Based Language Teaching (TBLT) in teaching grammar. In addition, this research aimed to investigate the challenges towards TBLT implementation in EFL classrooms. To collect the qualitative data, the researchers conducted semi-structured interviews with 14 EFL primary teachers and observed 16 language lessons. Willis’ (1996) model of TBLT and Vygotsky’s (1986) sociocultural theory were used as theoretical frameworks to get a holistic picture of TBLT implementation in teaching grammar. The researcher employed thematic analysis to generate themes. Two themes emerged for research question one: what are EFL teachers’ perceptions of using TBLT in teaching grammar? (communicative use of language and stress-free environment), and two themes emerged for research question two: what are the perceived challenges the implementation of TBLT poses for EFL teachers in teaching grammar? (lack of meaningful input and time allocation). Finally, some limitations, as well as recommendations, were addressed based on the main results of this qualitative research.