bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Cement Design for Water Shutoff Application in North Kuwait Heavy Oil Field
Authors: Pullanikkottil S. , Ibrahim M. , Elghoul S. , Bosilca D. , Gupta P. , Al-Hammadi E. K. , Al-Sairafi F. A. , Abdullah A. S. , Al-Ajmi A. M. , Monteiro K. 
Published: November 2023

Abstract
Kuwait Oil Company (KOC) have been actively recovering hydrocarbons from Heavy-oil reservoirs located in the Northern Kuwait (NK) Fields. Northern Kuwait Heavy Oil (NKHO) reserves are mainly located in two major fields: Field-1 (cold well) and Field-2 (thermal well). Currently, this heavy oil field is in the developmental phase, and KOC plans to add additional wells yearly. Field-2 is a thermal field, currently producing with a water cut of approximately 45%. Typically, water coning is a major challenge that hinders thermal recovery in a heavy oil reservoir with a bottom or boundary aquifer. This situation typically occurs when the production zone is near an aquifer or a water-bearing formation with a permeable connection, based on the ratio of horizontal to vertical permeability between the oil production zone and water formation. Coning occurs with pressure drawdown, causing water to migrate from the bottom to the wellbore. This is strictly a near-wellbore phenomenon that occurs only once the pressure forces drawing fluids toward the wellbore exceed the natural buoyancy forces that segregate gas and water from oil. Coning is a rate-sensitive phenomenon generally associated with high production rates. Although it can be controlled by decreasing the production rates, this approach is unfavorable because oil production is reduced and water production impacts the economic life of reservoirs and ultimate recovery. Moreover, it increases the operating expenses such as pumping, water/oil separation, and equipment costs. Additionally, excess water production causes wellbore corrosion, scaling, and sand production problems.
Because of the chemical complexity of the produced water, its disposal is a major environmental concern. This also increases the disposal costs. Therefore, developing a proper and economical method to shut off or lower excess water has become one of the most significant concerns of the KOC in the NKHO field. Field-2 is a relatively new emerging field with increased intervention complexity due to an increase in water cuts.
Early remedial job trials using conventional thermal slurries were unsuccessful in Field-2. This study illustrates the deployment of a novel cementing solution to address the challenges associated with conventional thermal cement for low-pressure, low-temperature, water-shut-off cement squeeze jobs. The slurry design and approach have good potential for vast applications in Kuwait and heavy oil fields worldwide.
Exploration of treatment in childhood Langerhans cell histiocytosis based on inflammatory and tumorous symptoms: A Pilot study
Authors: Lin Hui-ling , Zheng Qing-qing , Huang Ru-lin , Liu Xiao-dan , Wang Jiayi 
Published: November 2023

Abstract
Background: The outcome of multisystem childhood Langerhans cell histiocytosis (LCH), especially risk organ (RO) involvement patients, treated by the international traditional schemes had not been satisfactory and had a high incidence of reactivation with late sequelae. We observed that patients with different clinical symptoms showed different therapeutic responses to different drugs, suggesting that the method of grouping and selecting treatment strategies based only on the number of organs involved is inadequate. Based on the definition of LCH as an inflammatory myeloid tumor, this study innovatively divided children with LCH into inflammatory symptoms’ group and tumor symptoms’ group, and given different intensity treatment regimens accordingly, to explore a more appropriate treatment strategy.
\Methods: According to the clinical manifestations, 37 cases of children were divided into Group A (inflammatory symptoms) and Group B (tumor symptoms). Initial treatment, Group A used vindesine (VDS) and methylprednisolone (PSL); Group B used VDS, PSL, pirarubicin(THP) and cyclophosphamide (CTX). Treatment response was evaluated 6 weeks after the start of induction therapy in all patients, which assessed according to two criterias consisting of disease status and clinical scores of symptoms.
Results: Clinical scores pre- and post-treatment were 1.22 ± 0.547 and 0.00 ± 0.00 in Group A compared with 14.79 ± 1.686 and 1.00 ± 1.563 in Group B. Patients in both groups were all able to successfully enter maintenance treatment without progressive disease state. The overall survival (OS) of 4-year follow-up was 100% in both groups. The 4-year event-free survival (EFS) was 94.4% in Group A and 89.5% in Group B, respectively. There were no obvious adverse events in Group A, and the main adverse events in Group B were alopecia and non-lethal hematological toxicity.
Conclusion: Stratification according to patients’ clinical symptoms, with low-intensity treatment for inflammatory symptoms (mild manifestations) and intensive treatment with multiple drugs for tumor symptoms (severe manifestations), is a positive exploration that simplifies stratification method, achieves good long-term remission of the disease, and obtains a higher survival rate and quality of life, which seemed to be more appropriate for LCH patients.
Foliage to Fiber: Decoding the Nutritional efficiency and assimilation of different hosts on growth, reproduction and silk production of Samia ricini (Donovan) (Lepidoptera: Saturniidae)
Authors: Natarajan Lalitha , Hemachandran Hridya , Nath Arunima , Guha Lopamudra , Neog Kartik 
Published: November 2023

Abstract
Food consumption and conversion efficiency of eri silkworm Samia ricini (Donovan) were studied on castor, tapioca, and kesseru. Growth rate, consumption, and assimilation of food in five larval instars were analyzed. The total larval duration comprising five instar stages were found to complete in 18.33 ± 0.41, 19.92 ± 0.38, and 21.00 ± 0.45 days on castor, tapioca, and kesseru respectively. The ingesta recorded was significantly higher on the primary host castor (34.89 ± 1.15 g) as compared to tapioca (30.35 ± 0.94 g) and kesseru (29.49 ± 1.16g). The tissue growth rate was recorded on par for the first four instars on the three hosts studied. However, fifth-instar weight gain showed significant differences among the hosts. During the fifth instar, high feeding and assimilation rates were recorded in all the hosts studied, to meet the high energy demands of metabolic processes involved in synthesizing and spinning the cocoon as a protection for the succeeding non-feeding pupal stage. The single cocoon weight, pupal weight, and shell weight were found to be superior on castor, followed by tapioca and kesseru. However, the shell ratio percentage was found to be on par for all three hosts. The successful reproductive phase of the non-feeding adult stage was also dependent on the food energy accumulation during the larval stage. The reproductive phase study of the emerged adults reared on three hosts revealed that the effective egg production was on par on all three hosts.
Resting-state brain activation patterns and network topology distinguish human sign and goal trackers
Authors: Schettino Martino , Mauti Marika , Parrillo Chiara , Ceccarelli Ilenia , Giove Federico , Napolitano Antonio , Ottaviani Crisitina , Martelli Marialuisa , Orsini Cristina 
Published: November 2023

Abstract

The Sign-Tracking/Goal-tracking (ST/GT) is an animal model of individual differences in cue-reward learning offering a translational approach to investigate the vulnerability to impulse control disorders. In the present study, we mapped such model onto humans, on the one hand by adopting a new translational relevant Pavlovian paradigm and on the other by investigating resting state functional magnetic resonance imaging correlates in individuals categorized as more disposed to ST or GT. To do so, eye-tracking was used to classify humans as prone to STs (n = 36) or GTs (n = 35) or as intermediates (n = 33), depending on their eye-gaze towards the reward-related cue versus the reward location. Using both connectivity and network-based approach, measures of resting state functional connectivity and centrality (role of a node as a hub) replicated preclinical findings, suggesting a major involvement of subcortical areas in the ST phenotype, and a more cortical involvement in the GT phenotype. Overall, the study strengthens the translational value of the ST/GT model, with important implications for the early identification of vulnerable phenotypes for psychopathological conditions such as substance use disorder.

Martino Schettino and Marika Mauti share co-first authorship.
Event-scale impact and recovery of forest cover following wildfire in the Northern Rocky Mountains
Authors: Epstein Margaret , Seielstad Carl , Moran Christopher 
Published: November 2023

Abstract
Anthropogenic climate change is expected to catalyze forest conversion to grass and shrublands due to more extreme fire behavior and hotter and drier post-fire conditions. However, field surveys of wilderness areas in the Northern Rocky Mountains of the United States show robust conifer regeneration on burned sites. This study utilizes a machine learning (GBM) approach to systematically monitor canopy cover on burned areas in two large wilderness areas from 1985 to 2021. The predictive model was developed from coincident LiDAR and Landsat observations and used to create time series of canopy cover on 352 burned sites. Fire impact, as measured by canopy cover loss relative to pre-fire condition, was highly correlated with burn severity. Recovery was characterized by two metrics: whether or not a site exhibited signs of recovery, and the rate at which a site is recovering. Eighty-five percent of the land area studied showed evidence of recovery. Burned areas that are failing to recover are occurring more recently than their recovering counterparts, with 60% of non-recovering sites burning for the first time after 2003. However, the 5-year probability of recovery is similar among recent burns and for those that burned earlier in the record, suggesting that they may recover with more time. Once sites begin recovering, median time to reach pre-fire state is 40 years. Seven sites have projected recovery times greater than two hundred years, six of which burned for the first time after 2006. While fires that are failing to recover or recovering slowly make up proportionally small portions of the landscape, they may be of particular management interest as harbingers of future forest conversion, particularly under hotter and drier future climate scenarios. This work provides a framework for systematic monitoring into the future and establishes a baseline of recovery in the mountains of western Montana and northern Idaho.
Unlocking the Alchemy: An Analysis of Stainless Steel Creation via Fused Filament, De-Binding, and Sintering
Authors: Batra Raman , kumar Arun , Kumar Ritesh , Parikh Swapnil , chandra Rama , Sharma Vishal 
Published: November 2023

Abstract
Metal, plastic, ceramic, and composite components are made using the additive manufacturing process known as fused deposition modeling (FDM), which boasts zero waste and no need for molds. FDM has gained international attention for both complex and simple metal part production due to its simple setup and approachable process. Feeding filament into a 3D printer results in the extrusion of green components. These "green" components go through a process called thermal de-binding, which is a crucial step in the conversion of filaments into metal parts. Differentiating factors like heating rate, holding duration, and temperature play a role in the successful components made of 316L SS green Ultra fuse are thermally de-binded without creating any defects. Perfect thermal de-binding is accomplished by meticulously controlling these parameters.After de-binding, the Ultra fuse 316L metal is sintered to produce pieces with remarkable characteristics, including a peak, a hardness of 187.88 HV,density of 8.67 g/cm3, and a tensile strength of 570 MPa. This combination of FDM, precise thermal de-binding, and subsequent sintering demonstrates the potential to produce strong metal components with outstanding mechanical properties.
Imaging-Based Diagnosis of Sarcopenia for Transplant-Free Survival in Primary Sclerosing Cholangitis
Authors: Keshoofi Pedram , Schindler Philipp , Rennebaum Florian , Cordes Friederike , Morgul Haluk , Wildgruber Moritz , Heinzow Hauke S. , Pascher Andreas , Schmidt Hartmut H. , Hüsing-Kabar Anna , Praktiknjo Michael , Trebicka Jonel , Seifert Leon Louis 
Published: November 2023

Abstract

Background
Imaging-based assessment of sarcopenia is a well-validated prognostic tool for patients with chronic liver disease. However, little is known about its value in patients with primary sclerosing cholangitis (PSC). This cross-sectional study aimed to investigate the predictive value of the cross-sectional imaging-based skeletal muscle index (SMI) for transplant-free survival (TFS) in patients with PSC.
Methods
A total of 95 patients with PSC who underwent abdominal cross-sectional imaging between 2008 and 2022 were included in this retrospective study. SMI was measured at the third lumbar vertebra level (L3-SMI). The cut-off values to define sarcopenia were < 50 cm²/m² in male patients and < 39 cm²/m² in female patients. The primary outcome of this study was TFS, which was defined as survival without liver transplantation or death from any cause.
Results
Our study indicates that L3-SMI sarcopenia impairs TFS in patients with PSC (5-year TFS: 33.9% vs. 83.3%, p = 0.001, log-rank test). L3-SMI sarcopenia was independently associated with reduced TFS via multivariate Cox regression analysis (HR = 2.749; p = 0.028). Body mass index reduction > 10% at 12 months, which is used as MELD standard exception (SE) criterion in Eurotransplant (in Germany only until September 2023), was not significantly associated with TFS in the multivariate Cox regression analysis (HR = 1.417; p = 0.330). Substitution of BMI reduction with L3-SMI in the German SE criteria improved the predictive accuracy of TFS compared to the established SE criteria (multivariable Cox regression analysis: HR = 4.007, p < 0.001 vs. HR = 1.691, p = 0.141).
Conclusion
Imaging-based diagnosis of sarcopenia via L3-SMI is associated with a low TFS in patients with PSC and may provide additional benefits as a prognostic factor in patient selection for liver transplantation.
Modification of risk for all-cause and cardiovascular disease-related mortality with changes in the body mass index: A prospective cohort study with 12 years follow up
Authors: Lai Yun-Ju , Yen Yung-Feng , Chen Li-Jung , Hsu Li-Fei , Ahmadi Matthew N. , Inan-Eroglu Elif , Biswas Raaj Kishore , Ku Po-Wen , Stamatakis Emmanuel 
Published: November 2023

Abstract
Background: The longitudinal impact of changes in body mass index (BMI) on the risk of all-cause and cardiovascular disease (CVD)-related mortality has not been extensively studied. We examined whether changes in BMI status over time are associated with risk of all-cause and CVD-related mortality
Methods: This longitudinal study recruited 90,258 adults between 2002-2008 from the Taiwan MJ cohort who underwent repeated BMI measurements at an interval of 3.3 years and were followed up for all-cause and CVD-related mortalityover 12.1 years. Cox proportional hazard and Fine-Gray sub-distribution hazard models with death from non-CVD causes as the competing risk were used to determine the impact of changes in BMI status on the risk of all-cause or CVD-related mortality, respectively.
Results: Over 1,094,606 person-years of follow-up, 2,084 participants died, including 391 (18.8%) CVD-related deaths. After adjusting for other covariates, >10% increase (adjusted hazard ratio [aHR], 1.36; 95% confidence interval [CI], 1.09-1.70) or >10% decrease of BMI (aHR, 1.86; 95% CI, 1.43-2.43) was significantly associated with higher risk of all-cause mortality, compared with stable BMI. Participants with obesity at baseline who had BMI increase of >10% during the follow-up period had a significantly higher risk of all-cause (aHR = 2.30; 95% CI:1.38-3.85) and CVD-related mortality (aHR = 3.44; 95% CI:1.33-8.89).
Conclusions: A>10% increase in BMI in individuals with obesity was significantly associated with a higher risk of all-cause and CVD-related mortality. Our findings suggest that individuals with adiposity should adopt measures to reduce body weight to prevent premature mortality.
Antimicrobial Resistance Patterns in Hazara Division: A Cross-Sectional Study in The Pre-and Post-Covid-19 Era
Authors: Awais Muhammad , Fahad Shah , Rehman Masood Ur , Ayub Usman , Ahmad Kaleem , Awan Waqar Ahmed , Khan Dilawar , Waseem Muhammad 
Published: November 2023

Abstract
In COVID-19 there was a lot of misuse of antibiotics that caused the huge burden of antimicrobial resistance (AMR). The study focuses on the impact of COVID-19 on AMR. A total of 1200 samples of urine, PUS, wound, blood, and high vaginal swab (HVS) were collected out of which 529 samples were included while 200 were excluded. Selected samples were cultured and antibiotic disks were applied. Zone size determined antibiotic sensitivity, resistance levels. The statistical analysis was done by using R version 4.3.0. The most commonly isolated bacteria were Escherichia coli (46%) followed by the Staphylococcus spp (18.4%), Klebsiella spp (9.7%), Enterococcus spp (5.5%), Coliform spp (4.9%), Pseudomonas spp (3.6%), Enterobacter spp (3.2%), Candida spp (2.3%), Acinetobacter spp (2.1%), Salmonella typhi (1.1%), Streptococcus spp (1.1%), Proteus mirabilis (0.9%), Burkholderia cepacia (0.4%), Citrobacter freundii (0.5%), Morgenella spp (0.2%). In Females (76%) AMR while in males 23.6% AMR was observed. A total of 42 antibiotics AMR trend was seen out of which 21 antibiotics show an uptrend while others show a downtrend. During COVID-19 the increased use of antibiotics occurred so the increased AMR is seen in 2019 and 2020. Post-COVID-19 identification, reduced antibiotic usage resulted in an observed downward trend.
Is Community Pharmacies’ Personnel Well-Oriented about Cosmeceuticals? A Cross-sectional Survey and Costumer Simulation
Authors: Yousefi Nazila , Noqani Hesam , Mohammadnezhad Ghader , Foroughi Mohammad Javad , Peiravian Farzad 
Published: November 2023

Abstract
Background
The cosmetics business is one of the most profitable and advanced global trade sectors, and academic and industrial investments have expanded to provide high-quality products to the right consumers. Thus, this cross-sectional survey assessed Iranian pharmacists and pharmacy technicians' cosmetic product knowledge, attitudes, and behaviors.
Methods
Demographics were the first questionnaire section after eligibility and consent. Ten questions test knowledge in the second phase. The third portion has nine pharmacist cosmetic product attitudes questions. We used five-point Likert spectrum scaling. The final component of the questionnaire includes a pharmacist practice checklist. This fulfilled 12 pharmacists' obligations. PT demographics, knowledge, and attitude were measured using an eight-, five-, and eight-item questionnaire. A cosmetic sales checklist with eight practice items was devised to evaluate PTs. Pharmacists and PTs were evaluated for scientific advice on exfoliating lotion and anti-stain sunscreen use, skin type, history, and brand presentation. Using a 95% confidence interval, binary logistic regression found significant relationships between categorical dependent and independent variables. Pearson correlation measured knowledge-performance linearity.
Results
The study included 325 pharmacists and 324 PTs. The average knowledge score for pharmacists was 6.38 ± 1.95, while their practice score was 6.35 ± 1.92 out of 10. The overall knowledge score for PTs was 2.8 ± 0.92 out of 5. Results indicate a strong association between pharmacist and PT knowledge and cosmeceutical performance (r = + 0.635 and + 0.564, respectively, P < 0.001).
Conclusion
This study indicates a strong correlation between knowledge and performance in community pharmacists and PTs.
Predictive and prognostic value of excision repair cross-complementing group 1 by multi-omics on the outcomes in patients with advanced gastric cancer
Authors: Yamada Yasuhide , Nagashima Kengo , Azuma Mizutomo , Masutani Mitsuko , Ichikawa Hitoshi , Iwasa Satoru , Takahashi Naoki , Hirano Hidekazu , Kanato Keisuke , Machida Nozomu , Kinoshita Takahiro , Hata Hiroaki , Kawakami Hisato , Takahari Daisuke , Boku Narikazu , Kurokawa Yukinori , Terashima Masanori , Yoshikawa Takaki , Sekine Shigeki , Hiraoka Nobuyoshi 
Published: November 2023

Abstract
Background
To define the optimal chemotherapy regimen for each patient we therefore used tissue from patients to identify molecular prognostic or predictive biomarkers.
Methods
Endoscopic biopsy specimens from primary lesions and surgical specimens on a phase III trial in patients with unresectable advanced or recurrent gastric cancer treated with docetaxel with cisplatin plus S-1 (DCS) or cisplatin plus S-1 (CS), were collected. We measured the mRNA expression of ERCC1 and analyzed SNPs in GSTP1 and ERCC1.
Results
Low ERCC1 expression was associated with favorable prognosis for overall survival, OS by multivariable analysis (P = 0.001). There were significant interactions between the two treatment arms of DCS and CS, and ERCC1 mRNA expression. In patients with low ERCC1 expression of a favorable prognosis, DCS therapy was inferior to CS (P = 0.046). In addition to GSTP1 rs1695 (HR 1.728), ERCC1 rs3212980, ERCC1 rs2298881, ERCC1 rs3212964 with high expression of ERCC1 mRNA were associated with significantly worse prognosis with regard to OS.
Conclusions
ERCC1 mRNA is an independent prognostic factor and predictive marker that can be used to guide the addition of docetaxel. The SNPs of ERCC1 and GSTP1 could be also prognostic or predictive factors.
Clinical Trial Number: UMIN000007652
Development and validation of a prognostic nomogram for ovarian clear cell carcinoma: A study based on the SEER database and a Chinese cohort
Authors: Shen Yao , Zhao Pingge , Zhang Yuhang , Guo Guanlin , Jia Xueyuan , Wu Jie , Kuang Ye 
Published: November 2023

Abstract
Background: Based on the SEER database of patients diagnosed with OCCC from 2000 to 2018, the overall survival (OS) and cancer-specific survival (CSS) nomograms were constructed, and the OCCC patients from our hospital were used for external validation. We aim to develop scientifically valid prognostic models for OCCC.
Methods: Data were extracted from the SEER database for patients diagnosed with OCCC. Cox regression analyses were used to identify independent risk factors for OCCC. Two nomograms were developed and the results were evaluated comprehensively by C-index, ROC curve, calibration curve, and DCA curve. Finally, patients diagnosed with OCCC in our hospital were used as the validation set to verify the model.
Results: A total of 1855 OCCC patients from the SEER database were used as the training set and 101 patients from our hospital were used as the validation set. Cox regression analysis of the independent risk factors affecting the prognosis of OCCC was used to construct nomograms. The C-index of the training set OS was 0.76, and the validation set OS was 0.75. The AUC of the training set OS is 0.803, 0.794, and 0.802 for 1, 3, and 5 years, and 0.774, 0.800, and 0.923 for the validation set. The calibration curve and DCA curve also show that OS and CSS have good predictive power.
Conclusions: We constructed nomograms to predict the prognosis of OCCC. The nomograms have satisfactory accuracy and clinical practicability, which can guide the decision of clinicians.