bluuebunny/crossref_metadata_2025_split huggingface dataset:
A parameter map of cavitation from impacts between solids immersed in water
Authors: Cruz S. , Godínez F. A. , Ramos-Garcia R 
Published: October 2023

AbstractCavitation when two solids immersed in water collide has been studied theoretically and experimentally. A dimensionless parameter map showing a threshold line that delimits with good agreement the cavitation and non-cavitation zones was constructed. The threshold line was set by a cavitation number established with a lubrication model. Experiments were conducted using a device with a solid steel sphere colliding with a solid aluminum plane for different impact velocities and water column heights. When the impact forces are in the order of 100 to 1000 N, only cavitation generated by the rapid separation of solids in the liquid (CSSL) is observed; however, this type of cavitation along with cavitation due to tensile waves (TWC) are perceived for collision forces greater than 1000 N. In some events in which both types of cavitation (TWC-CSSL regime) appear, light emission also takes place. The kinematic coefficient of restitution and impact speed can be used to determine the cavitation onset, the transition from CSSL to TWC-CSSL regimes and the collision events in which photon production occurs. The obtained map will provide key information to develop potential applications as cavitation machining and surface treatment.
On a variant of Pillai’s problem with factorials and S-units
Authors: Faye Bernadette , Luca Florian , Ziegler Volker 
Published: October 2023

AbstractLet S be a finite, fixed set of primes. In this paper, we show that the set of integers c which have at least two representations as a difference between a factorial and an S-unit is finite and effectively computable. In particular, we find all integers that can be written in at least two ways as a difference of a factorial and an S-unit associated with the set of primes $$\{2,3,5,7\}$$

{
2
,
3
,
5
,
7
}

.
Feeling Emotions for Future People
Authors: Andina Tiziana , Sacco Giulio 
Published: October 2023

AbstractIt is more difficult to feel emotions for future generations than for those who currently exist, and this seems to be one of the reasons why we struggle to care for the future. According to a number of authors, who have recently focused on the psychological flaws that prevent us from dealing with transgenerational issues, the main problem is “future discounting”. Challenging this common view, we argue that the main reason we struggle to care about future generations lies in two features of our daily emotions: the «identified victim effect» and the decrease in empathy for people who are different from us. These traits give rise to two puzzles we call the problem of the indeterminateness of future persons and the problem of dissimilarity. After having analyzed these problems of our moral psychology, we show how they allow us to account for some differences in affectivity towards a number of entities that do not currently exist, such as future generations, past generations and fictional characters. Bearing in mind the real limits of our emotions when dealing with future people, we sketch an alternative proposal on how to develop emotions to provide citizens of liberal democracies with a motivation to act in favor of future generations.
Atypical ductal hyperplasia on vacuum-assisted breast biopsy: a scoring system to predict the risk of upgrade to malignancy
Authors: Rella Rossella , Conti Marco , Borghetti Alberto , Belli Paolo , Morciano Francesca , Rossati Claudia , Caneva Andrea , Di Leone Alba , Franceschini Gianluca , Gori Elisabetta , Fornasa Francesca , Tommasini Oscar , Romanucci Giovanna 
Published: October 2023

Abstract
Rationale and objectives
Our multicentric study analysed clinical, radiologic and pathologic features in patients with atypical ductal hyperplasia (ADH) diagnosed with vacuum-assisted biopsy (VAB), to identify factors associated with the risk of upgrade, to develop a scoring system to support decision making.

Materials and methods
Patients with ADH on VAB under stereotactic/tomosynthesis guidance (2012–2022) were eligible. Inclusion criteria were availability of surgical histopathological examination of the entire lesion or radiologic follow-up (FUP) ≥ 24 months. VAB results were compared with surgical pathological results or with imaging FUP evolution to assess upgrade. A backward stepwise linear regression was used to identify predictors of upgrade. The discriminatory power of the model was calculated through the area under the receiver operating curve (ROC–AUC); the Hosmer–Lemeshow test was used to assess model calibration. The points system was developed based on the selected risk factors, and the probability of upgrade associated with each point total was determined.

Results
112 ADH lesions were included: 91 (91/112, 81.3%) underwent surgical excision with 20 diagnosis of malignancy, while 21 (21/112, 18.7%) underwent imaging FUP with one interval change (mean FUP time 48 months). Overall upgrade rate was 18.7% (21/112). Age, menopausal status, concurrent breast cancer, BIRADS classification and number of foci of ADH were identified as risk factors for upgrade. Our model showed an AUC = 0.85 (95% CI 0.76–0.94). The points system showed that the risk of upgrade is < 2% when the total score is ≤ 1.

Conclusion
Our scoring system seemed a promising easy-to-use decision support tool for management of ADH, decreasing unnecessary surgeries, reducing patients’ overtreatment and healthcare costs.
Differential scanning calorimetry as a tool to assess the oxidation state of cold-pressed oils during shelf-life
Authors: Islam Mahbuba , Kaczmarek Anna , Tomaszewska-Gras Jolanta 
Published: October 2023

AbstractCold-pressed oils are highly prone to the peroxidation process, which causes a rapid decline in quality. Thus, there is a need to develop instrumental methods instead of conventional chemical analysis consuming large quantities of harmful chemicals. Differential scanning calorimetry (DSC) is a valuable analytical tool for assessing the oxidative stability of oils. Cold-pressed flaxseed, camelina and hemp seed oils from different cultivars, which had been stored for six months in room conditions under natural light exposure, were tested. Chemical methods for measuring changes in oxidative stability during storage of oils included determination of peroxide value (PV), p-Anisidine value (p-AV), total oxidation value (TOTOX) value and acid value (AV). Parameters like oxidation induction time (OIT) in isothermal mode (120, 140 °C) and onset temperature (Ton) in non-isothermal mode (heating rate 2, 5 °C/min) were established from DSC curves. Data for OIT and Ton plotted against time showed a strong, significant (p ≤ 0.05) descending trend for all oils. However, flaxseed and hempseed oils revealed a more rapid deterioration during storage compared to camelina seed oils. All DSC results showed promising repeatability of the oxidative characteristics for three types of cold-pressed oils, regardless of their origins in different cultivars. However, the most suitable for monitoring the deteriorative changes in oils during storage was the isothermal test carried out at a temperature of 120 °C, for which the correlations with chemical indicators (PV, p-AV, TOTOX) were highly significant (p ≤ 0.0001). Linear discriminant analysis (LDA) based on the DSC results revealed, that the first discriminating function significantly separated the fresh oils from stored oils. The study showed that, based on a starting point defined for fresh oils, the DSC technique can be used to effectively and ecologically monitor the deterioration of oils by oxidation, instead of harmful chemical analyses.
Emerging Medical Therapies for the Treatment of Obesity in Women with Cardiovascular Diseases
Authors: Behrooz Leili , Lenneman Carrie G. , Hamburg Naomi M. 
Published: October 2023

Abstract
Purpose of Review
In this review, the impact of obesity on cardiovascular disease in women and emerging anti-obesity pharmacologic treatments are discussed.

Recent Findings
Robust evidence demonstrates the burden of obesity across the lifespan in women and links obesity to a diverse set of cardiovascular diseases. Female-specific risk factors including sex hormones and pregnancy factors intersect with obesity and cardiovascular risk. Sustained weight loss has potential for cardiovascular benefits. Recent trials demonstrate cardiovascular benefits of emerging agents with weight loss effects including GLP-1 RA and SGLT2 inhibitors in women.

Summary
Treatment and prevention strategies for cardiovascular disease in obese women should include integration of weight management strategies including the targeted use of emerging pharmacologic therapies.
Time-weighted motion history image for human activity classification in sports
Authors: Komori Hideto , Isogawa Mariko , Mikami Dan , Nagai Takasuke , Aoki Yoshimitsu 
Published: October 2023

AbstractVision-based human activity classification has remarkable potential for various applications in the sports context (e.g., motion analysis for performance enhancement, active sensing for athletes, etc.). Recently, learning-based human activity classifications have been widely researched. However, in sports scenes in which more detailed and player-specific classifications are required, this is a quite challenging task; in many cases, only a limited number of datasets are available, unlike daily movements such as walking or climbing stairs. Therefore, this paper proposes a time-weighted motion history image, an effective image sequence representation for learning-based human activity classification. Unlike conventional MHI based on the assumption that “the newer frame is more important,” our method generates importance-aware representation so that the predictor can “see” the frames that contribute to analyzing the specific human activity. Experimental results have shown the superiority of our method.
A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation
Authors: Lei Yangyang , Zhou Boxuan , Meng Xiangzhi , Liang Mei , Song Weijian , Liang Yicheng , Gao Yushun , Wang Minghui 
Published: October 2023

Abstract
Background
Lipid metabolism is a key factor in tumorigenesis and drug resistance, and models related to lipid metabolism have shown potential to predict survival and curative effects of adjuvant therapy in various cancers. However, the relationship between lipid metabolism and prognosis and treatment response of lung adenocarcinoma (LUAD) are still unclear.

Methods
We enrolled seven bulk RNA-sequence datasets (GSE37745, GSE19188, GSE30219, GSE31547, GSE41271, GSE42127, and GSE72094) from the GEO database and one single-cell RNA-sequencing dataset (GSE117570) from the TISCH2 database. Non-negative matrix factorization (NMF) was utilized to construct the risk score model based on lipid score calculated by GSVA algorithm. Phs000452.v3, PMID: 26359337, PMID: 32472114, PRJEB23709 datasets were used to test the response to immunotherapy. Drug sensitivity analysis was assessed according to the GDSC database, and immunotherapy response was evaluated using the Wilcoxon test. Cellular function assays including clone formation, EDU assays and flow cytometry were implemented to explore the phenotype alteration caused by the knockdown of PTDSS1, which is one of key gene in risk score model.

Results
We analyzed both bulk and single-cell RNA sequencing data to establish and validate a risk score model based on 18 lipid metabolism-related genes with significant impact on prognosis. After divided the patients into two groups according to risk score, we identified differences in lipid-related metabolic processes and a detailed portrait of the immune landscapes of high- and low-risk groups. Moreover, we investigated the potentials of our risk score in predicting response to immunotherapy and drug sensitivity. In addition, we silenced PTDSS1 in LUAD cell lines, and found that the proliferation of the cells was weakened, and the apoptosis of the cells was increased.

Conclusion
Our study highlights the crucial roles of lipid metabolism in LUAD and provides a reliable risk score model, which can aid in predicting prognosis and response to immunotherapy. Furthermore, we investigated the roles of PTDSS1 in LUAD carcinogenesis, which showed that PTDSS1 regulated proliferation and apoptosis of LUAD cells.
Overconfidence: the roles of gender, public observability and incentives
Authors: Amirkhanyan Hayk , Krawczyk Michał , Wilamowski Maciej , Bokszczanin Paweł 
Published: October 2023

AbstractIn this project, we manipulate the public observability of forecasts and outcomes of a physical task. We explore how these manipulations affect overconfidence (OC). Participants in the experiment are asked to hold a weight after predicting how long they think they could do it for. Comparing the prediction and outcome times (in seconds) yields a measure of OC. We independently vary two dimensions of public observability (of the outcome and of the prediction). Additionally, we manipulate incentives to come up with an accurate prediction. This design allows us to shed light on the mechanism behind male and female OC. Following the existing literature, we formulate several hypotheses regarding the differences in predictions and outcomes for males and females in the presence of the public observability of predictions and outcomes. Our experimental data do not provide support to most of the hypotheses: in particular, there is no evidence of a gender gap in overconfidence. The most robust finding that emerges from our results is that incentives on making correct predictions increase participants’ forecasts on their own performance (by about 24%) and their actual performance as well, but to a lower extent (by about 8%); in addition, incentives to predict correctly in fact increase error for females (by about 33%).
Some properties of the extremal function for the Fuglede p-modulus
Authors: Ciska-Niedziałomska Małgorzata 
Published: October 2023

AbstractWe deal with the Fuglede p-modulus of a system of measures, focusing on three aspects. First, we combine results concerning Badger’s criterion for the extremal function, i.e., the function which realizes the p-modulus, and plans with barycenter in $$L^q$$

L
q

, which give an alternative—in a sense, probabilistic—approach to p-modulus. It seems that the correlation of these results has not yet been established. Second, we deal with families of measures for which the integral of the extremal function is one. On such a family, the p-modulus as well as the optimal plans are concentrated. We consider closures of these families and relate them with generic families of measures for which the extremal function exists. Finally, we compute the p-modulus and extremal function for finite families of measures.
Comparing Optimization Methods for Radiation Therapy Patient Scheduling using Different Objectives
Authors: Frimodig Sara , Enqvist Per , Carlsson Mats , Mercier Carole 
Published: October 2023

AbstractRadiation therapy (RT) is a medical treatment to kill cancer cells or shrink tumors. To manually schedule patients for RT is a time-consuming and challenging task. By the use of optimization, patient schedules for RT can be created automatically. This paper presents a study of different optimization methods for modeling and solving the RT patient scheduling problem, which can be used as decision support when implementing an automatic scheduling algorithm in practice. We introduce an Integer Programming (IP) model, a column generation IP model (CG-IP), and a Constraint Programming model. Patients are scheduled on multiple machine types considering their priority for treatment, session duration and allowed machines. Expected future arrivals of urgent patients are included in the models as placeholder patients. Since different cancer centers can have different scheduling objectives, the models are compared using multiple objective functions, including minimizing waiting times, and maximizing the fulfillment of patients’ preferences for treatment times. The test data is generated from historical data from Iridium Netwerk, Belgium’s largest cancer center with 10 linear accelerators. The results demonstrate that the CG-IP model can solve all the different problem instances to a mean optimality gap of less than $$1\%$$

1
%

within one hour. The proposed methodology provides a tool for automated scheduling of RT treatments and can be generally applied to RT centers.
Exploring Disparities in Self-Reported Mental Health Symptoms Across Professional Categories in Spain’s Emergency Medical Services: A Nationwide Cross-Sectional Study
Authors: Martínez-Caballero Carmen M. , Matellán-Hernández M. Paz , Polo-Portes Carlos Eduardo , Reques-Marugán Ana María , Soto-Cámara Raúl , Cardaba-García Rosa María , Thuissard Israel John , Navalpotro-Pascual Susana 
Published: October 2023

Abstract

Objective:
This study aimed to analyze stress, anxiety, depression, and self-efficacy levels among Spanish out-of-hospital emergency medical professionals from February 1, 2021, to April 30, 2021.

Methods:
A nationwide survey was completed by 1666 Emergency Medical Services (EMS) workers. The Depression, Anxiety, and Stress Scale (DASS-21) and the General Self-Efficacy Scale (GSE) were used. Data analysis used chi-squared, análisis of variance (ANOVA), and logistic regressions.

Results:
The sample comprised 833 (50%) men, with an average age of 44.3 ± 9.9 y (range: 19-67 y). Occupational distribution included 453 (27.2%) physicians, 474 (28.4%) nurses, and 739 (44.4%) emergency medical technicians (EMTs). EMTs exhibited higher odds of severe or extremely severe depression compared with physicians (odds ratio [OR]: 1.569; 95% confidenceinterval [95% CI]: 1.213-2.030) and nurses (OR: 1.561; 95% CI: 1.211-2.012). EMTs also displayed higher probabilities of severe or extremely severe anxiety compared with nurses (OR: 1.944; 95% CI: 1.529-2.701). Furthermore, EMTs demonstrated elevated probabilities of severe or extremely severe stress compared with physicians (OR: 1.387; 95% CI: 1.088-1.770). However, no significant differences were found in self-efficacy, with a median value of 73 [20].

Conclusions:
Out-of-hospital EMS workers experienced mental health challenges, showing varying levels of depression, stress, and anxiety across different occupational groups. EMTs were particularly affected.
Oligocene Orogen‐Parallel Extension in Southern Tibet During Indian Continental Subduction
Authors: Xue Weiwei , Hu Xiumian , Ma Anlin , Garzanti Eduardo , Liang Wendong , Hao Lulu , Wang Qiang 
Published: October 2023

AbstractThe controversial history of Indian subduction beneath Asia is crucial to understand the Himalayan orogeny and more in general the geodynamic process of continental subduction. New key information is here presented from the Oligocene‐Pliocene Shiquanhe Basin located in the southwestern Tibetan Plateau. The alluvial‐fan, lacustrine, and braided‐river sediments of the Oligocene Rigongla Formation were non‐conformably deposited onto the Upper Cretaceous Gangdese granitoid rocks and fed from erosion of the batholith itself and of associated Paleogene Linzizong volcanic rocks. Stratigraphic evidence testifies to the development of an orogen‐parallel intracontinental rift along the retro‐side of the Gangdese arc in the Oligocene, at the same time as the Kailas basin formed along the pro‐side of the Gangdese arc. The subsidence of these twin basins may have been caused by steepening of the subducting Indian continental slab or by the passage of a wave of dynamic topography during continuing subduction.
Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor
Authors: Turpin Anthony , Delliaux Carine , Parent Pauline , Chevalier Hortense , Escudero-Iriarte Carmen , Bonardi Franck , Vanpouille Nathalie , Flourens Anne , Querol Jessica , Carnot Aurélien , Leroy Xavier , Herranz Nicolás , Lanel Tristan , Villers Arnauld , Olivier Jonathan , Touzet Hélène , de Launoit Yvan , Tian Tian V. , Duterque-Coquillaud Martine 
Published: October 2023

Abstract
Background
Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate cancer, arising from resistance to androgen-deprivation therapies. However, the molecular mechanisms associated with NEPC development and invasiveness are still poorly understood. Here we investigated the expression and functional significance of Fascin-1 (FSCN1), a pro-metastasis actin-bundling protein associated with poor prognosis of several cancers, in neuroendocrine differentiation of prostate cancer.

Methods
Differential expression analyses using Genome Expression Omnibus (GEO) database, clinical samples and cell lines were performed. Androgen or antagonist’s cellular treatments and knockdown experiments were used to detect changes in cell morphology, molecular markers, migration properties and in vivo tumour growth. Chromatin immunoprecipitation-sequencing (ChIP-Seq) data and ChIP assays were analysed to decipher androgen receptor (AR) binding.

Results
We demonstrated that FSCN1 is upregulated during neuroendocrine differentiation of prostate cancer in vitro, leading to phenotypic changes and NEPC marker expression. In human prostate cancer samples, FSCN1 expression is restricted to NEPC tumours. We showed that the androgen-activated AR downregulates FSCN1 expression and works as a transcriptional repressor to directly suppress FSCN1 expression. AR antagonists alleviate this repression. In addition, FSCN1 silencing further impairs in vivo tumour growth.

Conclusion
Collectively, our findings identify FSCN1 as an AR-repressed gene. Particularly, it is involved in NEPC aggressiveness. Our results provide the rationale for the future clinical development of FSCN1 inhibitors in NEPC patients.
Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality
Authors: von Auw Nadine , Serfling Robert , Kitte Reni , Hilger Nadja , Zhang Chengkang , Gebhardt Clara , Duenkel Anna , Franz Paul , Koehl Ulrike , Fricke Stephan , Tretbar U. Sandy 
Published: October 2023

AbstractProcess development for transferring lab-scale research workflows to automated manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies. Therefore, the key factor for cell viability, expansion, modification, and functionality is the optimal combination of medium and T cell activator as well as their regulatory compliance for later manufacturing under Good Manufacturing Practice (GMP). In this study, we compared two protocols for CAR-mRNA-modified T cell generation using our current lab-scale process, analyzed all mentioned parameters, and evaluated the protocols’ potential for upscaling and process development of mRNA-based CAR-T cell therapies.