An Insight into the Mechanism, Safety and Efficacy for Photoprotection
and Dermatological Conditions of Polypodium leucotomos Extract
Authors: Mawia Darthan , Das Aparoop , Umbon Yasangam , Saikia Riya , Pathak Kalyani , Pathak Manash Pratim 
Published: February 2024

Abstract:
Numerous photoprotective techniques have been employed to successfully shield against
the harmful effects of ultraviolet radiation. Current photoprotective techniques have limitations due
to the amount of topical application, insufficient physical protection, and adverse responses to topical
agents. A newer option that offers a promising defense against solar radiation is systemic agents, the
well-researched Polypodium leucotomos is significant in this category, and several studies have found
to be effective ―oral sunscreenǁ. Polypodium leucotomos (PL) extract has gained significant attention
as a potential therapeutic agent in the field of dermatology, particularly in the photoprotection and
management of various dermatological conditions. This abstract provides a comprehensive overview
of the mechanism, safety, and efficacy of Polypodium leucotomos extract in relation to photoprotection
and dermatological conditions. Our primary aim is to review Polypodium leucotomos' photoprotective
results from studies that are currently available, and our secondary goal is to describe Polypodium
leucotomos' applications in different dermatological conditions. Articles discussing Polypodium
leucotomos uses in photoprotection and dermatologic conditions are searched and downloaded from
publicly available databases such as PubMed, JSTOR, PLOS, Science Direct, DOAJ, Google Scholar,
and Web of Science and evaluate the outcomes of the Polypodium leucotomos effect. Firstly, we
delve into the mechanisms underlying the photoprotective properties of PL extract. Extensive research
has demonstrated that PL extract exerts its protective effects through multiple pathways, including
antioxidant activity, DNA repair stimulation, immunomodulation, and inhibition of inflammatory
mediators. These mechanisms collectively contribute to the prevention of photodamage,
such as sunburn, DNA damage, and photoaging. Furthermore, we explore the safety profile
of PL extract, emphasizing its remarkable tolerability and minimal adverse effects reported in clinical
studies. The absence of systemic absorption and its compatibility with other treatments make PL
extract a promising option for long-term use in photoprotection and dermatological care. A promising
alternative to traditional photoprotection may be Polypodium leucotomos. Additional thorough
clinical trials are necessary to ascertain its role and effectiveness more accurately. The efficacy of PL
extract in managing various dermatological conditions is also discussed. Multiple studies have
demonstrated its beneficial effects in conditions such as vitiligo, melasma, psoriasis, and atopic dermatitis.
The anti-inflammatory and immunomodulatory properties of PL extract have shown promise
in reducing disease severity, improving skin symptoms, and enhancing the quality of life for patients.
Additionally, the abstract highlights the potential future directions and areas of research for PL extract.
Investigating its combination therapy with other photoprotective agents, exploring optimal
dosage regimens, and further elucidating the molecular mechanisms are areas that warrant attention.
In conclusion, this abstract provides an insightful overview of the mechanisms, safety, and efficacy of
PL extract in photoprotection and dermatological conditions. The remarkable properties of PL extract,
combined with its favorable safety profile, position it as a promising therapeutic intervention in dermatology.
Further research and clinical trials are needed to fully exploit its potential and establish its
place in the management of various skin conditions.