bluuebunny/crossref_metadata_2025_split huggingface dataset:
AP-1 signaling modulates cardiac fibroblast stress responses
Authors: Whitehead Alexander J. , Atcha Hamza , Hocker James D. , Ren Bing , Engler Adam J. 
Published: November 2023

ABSTRACT
Matrix remodeling outcomes largely dictate patient survival post myocardial infarction. Moreover, human-restricted noncoding regulatory elements have been shown to worsen fibrosis, but their mechanism of action remains elusive. Here, we demonstrate, using induced pluripotent stem cell-derived cardiac fibroblasts (iCFs), that inflammatory ligands abundant in the remodeling heart after infarction activate AP-1 transcription factor signaling pathways resulting in fibrotic responses. This observed signaling induces deposition of fibronectin matrix and is further capable of supporting immune cell adhesion; pathway inhibition blocks iCF matrix production and cell adhesion. Polymorphisms in the noncoding regulatory elements within the 9p21 locus (also referred to as ANRIL) redirect stress programs, and in iCFs, they transcriptionally silence the AP-1 inducible transcription factor GATA5. The presence of these polymorphisms modulate iCF matrix production and assembly and reduce cell–cell signaling. These data suggest that this signaling axis is a critical modulator of cardiac disease models and might be influenced by noncoding regulatory elements.
One Week of Single Leg Immobilization Lowers Muscle Connective Protein Synthesis Rates in Healthy, Young Adults
Authors: Holwerda Andrew M. , Weijzen Michelle E. G. , Zorenc Antoine , Senden Joan , Jetten Guus H. J. , Houben Lisanne H. P. , Verdijk Lex B. , van Loon Luc J. C. 
Published: November 2023

ABSTRACT

Purpose
Short periods of limb immobilization lower myofibrillar protein synthesis rates. Within skeletal muscle, the extracellular matrix of connective proteins is recognized as an important factor determining the capacity to transmit contractile force. Little is known regarding the impact of immobilization and subsequent recovery on muscle connective protein synthesis rates. This study examined the impact of one week of leg immobilization and two weeks of subsequent ambulant recovery on daily muscle connective protein synthesis rates.

Methods
Thirty healthy, young (24 ± 5 y) men were subjected to 7 days of one-legged knee immobilization followed by 14 days of ambulant recovery. Deuterium oxide ingestion was applied over the entire period and muscle biopsy samples were collected before immobilization, after immobilization, and after recovery to measure muscle connective protein synthesis rates and mRNA expression of key extracellular matrix proteins (collagen I, collagen III), glycoproteins (fibronectin, tenascin-C), and proteoglycans (fibromodulin, and decorin). A two-way repeated measures (time x leg) ANOVA was used to compare changes in muscle connective protein synthesis rates during immobilization and recovery.

Results
During immobilization, muscle connective protein synthesis rates were lower in the immobilized (1.07 ± 0.30 %/d) compared with the non-immobilized (1.48 ± 0.44 %/d; P < 0.01) leg. When compared to the immobilization period, connective protein synthesis rates in the immobilized leg increased during subsequent recovery (1.48 ± 0.64 %/d; P < 0.01). Following recovery, skeletal muscle collagen I, collagen III, fibronectin, fibromodulin, and decorin mRNA expression increased when compared to the post-immobilization timepoint (all P < 0.001).

Conclusions
One week of leg immobilization lowers muscle connective protein synthesis rates. Muscle connective protein synthesis rates increase during subsequent ambulant recovery, which is accompanied by increased mRNA expression of key extracellular matrix proteins.
A Mean-Field Control Problem of Optimal Portfolio Liquidation with Semimartingale Strategies
Authors: Fu Guanxing , Horst Ulrich , Xia Xiaonyu 
Published: November 2023

We consider a mean-field control problem with càdlàg semimartingale strategies arising in portfolio liquidation models with transient market impact and self-exciting order flow. We show that the value function depends on the state process only through its law, and we show that it is of linear-quadratic form and that its coefficients satisfy a coupled system of nonstandard Riccati-type equations. The Riccati equations are obtained heuristically by passing to the continuous-time limit from a sequence of discrete-time models. A sophisticated transformation shows that the system can be brought into standard Riccati form, from which we deduce the existence of a global solution. Our analysis shows that the optimal strategy jumps only at the beginning and the end of the trading period. Funding: Financial support is through the National Natural Science Foundation of China [Grants 12101465 and 12101523], Hong Kong Research Grants Council (Early Career Scheme) [Grant 25215122], Hong Kong Polytechnic University [Internal Grant P0044694, Internal Grant P0045668, and Startup Grant P0035348], and the Hong Kong Research Centre for Quantitative Finance [Grant P0042708].
Model pembelajaran probalisi (Problem Based Learning with Science Islamic Integrated) materi kesehatan reproduksi dalam meningkatkan efikasi diri di era society 5.0
Authors: Hidayat Panji , Ulfah Amaliyah 
Published: November 2023

Tujuan penelitian ini adalah; (a) mendeskripsikan karakteristik model pembelajaran Probalisi; (b) mengetahui respon mahasiswa pada pembelajaran model Probalisi pada materi Reproduksi dalam meningkatkan efikasi diri; (c) mengetahui efektivitas buku model pembelajaran Probalisi pada materi kesehatan reproduksi, dan; (d) untuk mengetahui pelaksanaan pembelajaran model pembelajaran probalisi pada mata kuliah IPA Dasar Materi Kesehatan Reproduksi. Penelitian ini merupakan penelitian pengembangan atau RnD dengan model ADDIE dengan subjek penelitian adalah mahasiswa PGSD semester gasal Tahun Ajaran 2022/2023 pada Mata Kuliah IPA Dasar Angkatan Tahun 2022. Hasil penelitian didapatkan bahwa; (a) Didapatkan desain pembelajaran Probalisi dengan mengadaptasi Model Problem Based Learning dengan mengubah sedikit sintaks-sintaksnya; (b) Berdasarkan angket yang digunakan untuk mengukur efikasi diri mahasiswa sebanyak 40 mahasiswa diperoleh total skor hasil 520 dengan rata-rata nilai 13 (82,25 %) dan dikategorikan sangat baik dan sangat layak digunakan untuk memenuhi kebutuhan materi pengayaan Kesehatan Reproduksi; (c) Untuk buku yang digunakan dalam penelitian berdasarkan dosen A dan dosen B yang mengajar pada materi yang sama dalam satu program studi PGSD Universitas Ahmad Dahlan didapatkan skor total adalah 85 (97%) dikategorikan sangat baik); (d) Untuk pelaksanaan pembelajaran probalisi pada kesehatan reproduksi berdasarkan penilaian 2 orang peer reviewer didapatkan skor total 30 (88,24%) dengan kategori sangat baik. Pembelajaran ini begitu sangat bersinergi dengan pengetahuan agama awal mahasiswa karena semua ilmu itu bersumber dari Al Quran dan As Sunnah. Oleh karena itu perlunya dikembangkan pembelajaran probalisi agar semua selamat menganut hukum dan ketatapan yang Allah buat untuk manusia, bukan hukum positif manusia yang serba tentatif kebenarannya
Treatment of postpartum depression with integrated traditional Chinese and Western medicine nursing and electrical stimulation
Authors: Zhai Wen-Hui , Wang Mei-Jiao , Zhao Yi-Jing , Hu Shuang-Ling , Zhou Jin-Man 
Published: November 2023

BACKGROUND
Postpartum depression (PPD) is a common psychological disease among puerperal women, and postpartum pelvic floor dysfunction is a common disease among pregnant women. The occurrence of postpartum pelvic floor dysfunction will increase the incidence of PPD.
AIM
To explore the therapeutic effect of integrated traditional Chinese and Western medicine nursing combined with electrical stimulation of pelvic floor muscles and the rectus abdominis on PPD.
METHODS
From April 2020 to January 2022, 100 parturients with a rectus abdominis muscle separation distance > 2.0 cm who underwent reexamination 6 wk after delivery at our hospital were selected as the research subjects. According to the random number table method, the patients were divided into either an observation group (n = 50) or a control group (n = 50). There was no significant difference in the general data between the two groups (P > 0.05). Both groups were treated by electrical stimulation. The observation group was additionally treated by integrated traditional Chinese and Western medicine nursing. A self-designed Depression Knowledge Questionnaire was used to evaluate the awareness of knowledge on depression in all patients 3 wk after intervention. The Hamilton Depression Scale (HAMD) was used to evaluate the depression before intervention and 1 wk and 3 wk after intervention, and the Morisky Medication Adherence Scale (MMAS-8) was used to evaluate the medication compliance. SPSS19.0 was used for statistical analyses.
RESULTS
The rate of awareness of knowledge on depression in the observation group was significantly higher than that of the control group (P < 0.05). The scores of MMAS-8 were comparable between the two groups before intervention (P > 0.05), but were significantly higher in the observation group than in the control group at 1 wk and 3 wk after intervention (P < 0.05). The HAMD scores were comparable between the two groups before intervention (P > 0.05), but were significantly lower in the observation group than in the control group at 1 wk and 3 wk after intervention (P < 0.05).
CONCLUSION
Integrated traditional Chinese and Western medicine nursing combined with electrical stimulation of pelvic floor muscles and the rectus abdominis is effective in the treatment of postpartum depression and worthy of clinical promotion.
Las metáforas del periodismo: mutaciones y desafíos, Adriana Amado (2021)
Authors: Arriagada Eduardo 
Published: November 2023

Review of: Las metáforas del periodismo: mutaciones y desafíos, Adriana Amado (2021)
Buenos Aires and Madrid: Ediciones Ampersand, 328 pp.,
ISBN 978-9-87416-165-9, p/bk, €18.00
Is the Stick Real? Trends from Concluded Prosecutions of Industrial Environmental Crimes in South Africa
Authors: Strydom Melissa , Field Tracy-Lynn 
Published: November 2023

South Africa’s suite of environmental laws contains many criminal sanctions and penalty provisions. Whether the criminal sanction is an effective tool that realises the constitutionally protected environmental right depends on how it is practically enforced and whether potential offenders become aware of such enforcement measures. This article reports on research aimed at collecting and analysing prosecutions for industry-related transgressions (conducted mainly in Magistrate’s Courts) and involving offences under the National Environmental Management Act (NEMA), the Waste Act, the Air Quality Act and the National Water Act. An analysis of 53 prosecutions shows that most cases resulted in convictions, half were concluded through plea and sentence agreements, half involved the conviction of individuals, no direct imprisonment penalties were imposed, and low fines were imposed in most cases. The findings include that there is some inconsistency in how different listed activities or water uses are treated as separate or consolidated criminal charges, and the exact number, outcome or trends arising from such cases are difficult to determine as there is no central, readily accessible database of concluded prosecutions. Increased access to such information would improve knowledge, implementation and the effective use of the criminal sanction through prosecutions. In turn, this would contribute to the improved realisation of the constitutionally protected environmental right.
Un futur qui manque: sur quelques pièces de théâtre togolaises
Authors: Jakubczuk Renata , Wołowski Witold 
Published: November 2023

Les observations contenues dans le présent article concernent six pièces de théâtre togolaises strictement contemporaines (quatre miniatures dramatiques—Sous le grand kapokier… de Roger Atikpo, Jumel’âge de Jean Kantchébé, Tobbie, frères et sœurs ont la douleur de Rodrigue Norman, Tac-tic à la rue des Pinguins de Gustave Akakpo—et deux textes de dimensions normales : Atterrissage de Kangni Alem et Tanse-maître(s) d’Elemawusi Agbedjidji). Sur le plan esthétique, les analyses visent à décrire les attitudes assumées par les personnages envers le manque d’avenir qui caractérise l’univers dans lequel ils évoluent. Ces considérations s’organisent en deux sections : dans la première, nous nous focalisons sur les éléments traumatisants du passé qui rendent difficile, voire impossible, le dépassement du passé/présent vers un avenir ; dans la seconde nous analysons les éléments relatifs à l’image de l’avenir (ou de son absence) qui se dégage des textes, ainsi que les tentatives faites par les personnages pour surmonter l’apathie et l’inertie. Sur le plan théorique, nous soutenons la thèse selon laquelle, les textes étudiés constituent la preuve d’un certain échec des grandes opérations sociopolitiques et idéologiques (le système du postcolonialisme et le fétiche du développement) qui avaient pour l’objectif l’amélioration de la situation sur le continent africain, et qui sont actuellement remises en cause à travers les débats les plus récents.
Principles and approaches in the development of fluorescent hydrogels for cancer diagnosis
Authors: Sokolov P. M. , Samokhvalov P. S. , Baranova D. A. , Sukhanova A. V. 
Published: November 2023

Introduction. Early sensitive and highly specific diagnosis is crucial for successful cancer therapy. The use of fluorescent hydrogels (FHG) makes it possible to develop versatile biosensors due to the increased binding capacity of biological capture and reporter molecules, sensitive fluorescence detection, and the flexibility of combining their structural and functional elements.Aim. Analyzing the principles of designing biosensors based on FHG for the detection of cancer markers and the methodological approaches to their development, as well as summarizing and systematizing the data on the principles of detection and target signal generation used in these sensors.Results. FHG represent 3D sensing platforms, i. e., structures that combine the reporter fluorescence function with biological capture molecules, allowing the unique optical properties of fluorescent nanocrystals at the macro level to be preserved. The porous structure of hydrogels increases the active surface area of biosensors for 3D immobilization of fluorescent labels and biological capture molecules, while preserving the structure of these molecules, which ensures specific binding of the detected molecules of the sample. This ensures a higher sensitivity compared with the traditional methods of immunoenzymatic and immunochromatographic analyses. Not only the traditionally used antibodies, but also enzymes and glycoproteins, aptamers and oligonucleotides, as well as polymers obtained by molecular imprinting, can serve as biological capture molecules, which extends the range of specifically detectable analytes.Conclusion. The review presents examples of biosensors based on FHG intended for the detection of cancer markers and describes approaches to the preparation of FHG and immobilization of biological capture molecules, as well as principles of generation of the detected optical signal. The main advantages of fluorescent hydrogel biosensors over the classical tests used for quick diagnosis of cancer are shown.
Analysis of the <i>IL-10</i> mRNA level in the peripheral blood of patients with cancer and benign prostatic hyperplasia
Authors: Korovin O. A. , Alyasova A. V. , Arioua Kh. M. , Novikov D. V. , Krasnogorova N. V. , Novikov V. V. 
Published: November 2023

Background. Interleukin-10 (IL-10) is a pleiotropic cytokine with immunomodulatory properties and may inhibit tumor development and progression or stimulate tumor growth.Aim. Analysis of the changes of the IL-10 mRNA level in the peripheral blood (PB) of patients with prostate cancer (PC) and benign prostatic hyperplasia (BPH) in comparison with clinical and laboratory data.Materials and methods. 63 patients with histologically confirmed PC and 52 patients with histologically confirmed BPH were under observation. The control group consisted of 30 practically healthy persons comparable in age. Determination of the relative level of IL-10 mRNA in PB samples was performed by real-time reverse transcription polymerase chain reaction.Results. Both in patients with PC and in patients with BPH, a statistically significant decrease in the level of IL-10 mRNA in the PB of patients was observed in comparison with the control. In PC, the lowest levels were found in patients with a prostate-specific antigen (PSA) concentration above 10 ng / l and with a prostate volume of more than 50 cm3. Differences in the level of IL-10 mRNA at T2 and T3 stages and at different testosterone concentrations were not statistically significant, although there was a pronounced downward trend in prognostically unfavorable cases. Patients with BPH had a relative level of IL-10 mRNA, which was statistically significantly higher than in patients with PC. At PSA concentrations above 10 ng / mL, the level of IL-10 mRNA was also lower than at its lower concentrations.Conclusion. In patients with cancer and BPH, a reduced level of IL-10 mRNA was found in the PB. The decrease is more pronounced in the unfavorable course of diseases and, apparently, is a consequence of the instability of IL-10 mRNA at the post-transcriptional level.
Relato de experiência sobre um programa de assistência domiciliar do idoso em um município do estado do Pará: produção de cuidado em territórios afetivos
Authors: Cardoso Márcia Roberta de Oliveira , Ferla Alcindo Antônio , Gonçalves Aparecida Tereza de Anchieta Ferreira , Furtado Bianca Portal , Cunha Evelyn Cristina Martins , Silva Renato Oliveira da 
Published: November 2023

Objetivo: Este artigo tem por finalidade a apresentação de um relato de experiência do perfil, organização, processo de trabalho e funcionamento de um Programa de Assistência Domiciliar do Idoso de um município do Estado do Pará, desenvolvido a partir da realidade vivenciada no campo do trabalho em equipe. Metodologia: Optou-se pelo relato de experiência como modalidade de estudo, que permite analisar e observar variáveis significativas da realidade acerca do desenvolvimento do cuidado realizado aos sujeitos. Resultados: Foi possível refletir sobre os processos de trabalho e práticas de cuidado que norteiam a modalidade da Atenção Domiciliar, considerando que essa modalidade de assistência se caracteriza como valioso passo a ser exercido no campo de atenção aos idosos, pois além de ampliação da autonomia desta população e sua rede de apoio, diminui riscos psicossociais, diminui a hospitalização e colabora para um melhor suporte emocional para aqueles que se encontram em estado grave ou em fase final de vida. Ficou evidente a necessidade de maior valorização dessa modalidade de assistência, tanto no campo da macropolítica como no da micropolítica. O Programa de internação domiciliar da pessoa idosa, que está em funcionamento há 20 anos, apresenta um grande potencial no sentido de contribuir para processo de desospitalização, redução de custos, otimização do uso de leitos hospitalares e centralização do cuidado no usuário. Entretanto, apesar dos avanços já ocorridos desde a criação do serviço, alguns desafios ainda permanecem, dentre eles a dificuldade de articulação com os demais serviços da Rede Intersetorial e de Atenção à Saúde.

Palavras-chave: Saúde do Idoso; Atenção Domiciliar; Práticas de Cuidado e Processo de Trabalho em Saúde.
The relationship between activation of the coagulo‑fibrinolytic system and aseptic inflammation in patients with long‑term chronic thromboembolic pulmonary hypertension
Authors: Simakova M. A. , Zolotova E. A. , Zhilenkova Yu. I. , Melnichnikova O. S. , Karpov A. A. , Vavilova T. V. , Moiseeva O. M. 
Published: November 2023

Background. Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease with a poor prognosis. The role of monocytic-macrophage inflammation in the incomplete recanalization of acute thromboembolic pulmonary artery disease and the formation of CTEPH was shown. The role of the coagulo-fibrinolytic system in the pathogenesis of CTEPH remains controversial.Objective. To assess the activity of the coagulo-fibrinolytic system and its relationship with the level of monocytic chemotactic factor 1 (MCP-1), as well as the severity of the disease in patients with long-term CTEPH.Design and methods. The study included 44 patients diagnosed with CTEPH: 21 men (mean age 57,0 ± 11,9 years) and 23 women (mean age 53,8 ± 14,7 years). The diagnosis of CTEPH was verified according to the clinical guidelines of the Ministry of Health of the Russian Federation for the diagnosis and management of patients with pulmonary hypertension from 2020. The control group consisted of healthy donors (n = 19, mean age 51,0 ± 11,9 years, 10 men, 9 women). All patients were on anticoagulant therapy with enoxaparin sodium at a therapeutic dose of 1 mg/kg subcutaneously twice a day. The study of markers of the fibrinolysis and inflammation system was carried out by enzyme immunoassay: thrombin-activated fibrinolysis inhibitor (TAFI), tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), monocytic chemotactic factor 1 (MCP-1).Results. In the CTEPH group, an increase in the level of t-PA was demonstrated — 6,06 [4,502; 8,03] vs 2,95 [2,75; 3,56] ng/ml in donors (p = 0,00001). The levels of PAI-1 and TAFI did not differ in patients (34,40 [22,47; 46,43] and 94,67 [90,03; 102,80] ng/mL, respectively) and donors (24,93 [21,41; 43,88] and 92,68 [87,99; 98,29] ng/ml, respectively) (p = 0,0970 and p = 0,233). A significant increase in the level of MCP-1 was found in patients with CTEPH compared to donors (34,95 [31,00; 42,08] vs 26,05 [20,40; 31,33] pg/ml, p = 0,016, respectively). A correlation was noted between MCP-1 and fibrinolysis indices t-PA (0,402, p = 0,046), PAI-1 (0,437, p = 0,029). Correlations of MCP-1 and fibrinolysis markers with hemodynamic and physical performance indicators are also shown: MCP-1 and SvO2 (–0,574, p = 0,002), MCP-1 and cardiac index (CI) (–0,614, p = 0,001), distance in the six-minute walk test (6MWT) and t-PA (–0,435, p = 0,006).Conclusions. As a result of the study, the relationship between MCP-1 and the activity of the coagulo-fibrinolytic system and the severity of CTEPH was demonstrated. The data obtained can be used to further study the pathogenesis of postthromboembolic syndrome and develop criteria for assessing prognosis in patients with CTEPH.