bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotective effects of glucose-lowering drugs in rat focal brain ischemia-reperfusion model
Authors: Simanenkova A. V. , Fuks O. S. , Timkina N. V. , Tikhomirova P. A. , Vlasov T. D. , Karonova T. L. 
Published: December 2023

Background.Ischemic stroke is one of the leading causes of death in patients with type 2 diabetes mellitus (DM). According to the results of clinical and experimental studies, the ability of glucagon-like peptide-1 receptor agonists (GLP-1RA) to reduce the risk and severity of stroke in DM has been proven; data on the sodium-glucose cotransporter-2 inhibitors (SGLT-2i) effect are scarce. There has been no direct comparative study of the GLP-1RA and SGLT-2i neuroprotective effect.Objective.To evaluate and to compare the effect of GLP-1RA of varying duration of action and SGLT-2i of varying selectivity on the neurological deficit severity and the brain damage volume in a transient focal brain ischemia model in rats without DM.Design and methods.Male Wistar rats were divided into groups (n = 10 each) depending on the therapy received: “EMPA” (empagliflozin per os 2 mg/kg once daily), “CANA” (canagliflozin per os 25 mg/kg once daily), “LIRA” (liraglutide 1 mg/kg s. c. once daily), “DULA” (dulaglutide 0,12 mg/kg s. c. every 72 hours), “SEMA” (semaglutide 0,012 mg /kg s. c. once daily), “MET” (metformin per os 200 mg/kg once daily — comparison group), “Control” (administration of 0,9 % NaCl solution s. c. once daily). After 7 days, all groups underwent transient focal 30-minute filament middle cerebral artery occlusion. After 48 hours of reperfusion, neurological deficit was assessed using the Garcia scale, then the brain was collected and sections were stained with 1 % triphenyltetrazolium chloride solution to calculate the damage volume.Results.Neurological deficit severity in the “LIRA” (14,50 (12,25; 15,25) points) and “SEMA” (14,00 (13,50; 18,00) points) groups was significantly less than in the “Control” group (11.00 (6,75; 12,00) points). The use of both SGLT-2i, as well as metformin, had no effect on the neurological status. At the same time, therapy with all study drugs had an infarct-limiting effect, compared with the “Control” group (damage volume 24,50 (14,69; 30,12) % of the total brain volume). At the same time, the brain damage volume in the “MET” group (12,93 (6,65, 26,66) %) was greater than that in the “EMPA” (6,08 (2,97, 7,63) %), “CANA” (5,11 (3,96; 8,34) %), “LIRA” (3,40 (2,09; 8,08) %), “DULA” (4,37 (2,72; 5,40) %), “SEMA” (5,19 (4,11; 7,83) %) groups.Conclusions.SGLT-2i of varying selectivity and GLP-1RA of varying duration of action have a similar infarct-limiting effect in acute experimental brain ischemia. At the same time, GLP-1RA neuroprotective potential is higher, as it is characterized by an additional positive effect on the neurological status.
Promising varieties of berry crops (everbearing raspberry, garden strawberry) by economically useful characteristics in the conditions of the Komi Republic
Authors: Yudin A. , Pavlova E. , Tarabukina T. , Smetanina K. 
Published: December 2023

This article discusses the varieties of berry crops, particularly everbearing raspberry and garden strawberry, which are important sources of vitamin products. The results of the study will help to select suitable varieties of berry crops for cultivation in the Komi Republic and contribute to the development of agriculture in the region. During the study, it was found that the most promising varieties of everbearing raspberry for cultivation in the Komi Republic are Nedosyagaemaya and Bryanskoe Divo and those of garden strawberry - Bereginya and Geyser.
Diclofenac analysis in natural waters using UV-visible absorption spectrometric method
Authors: Bakhoum Jean-Marie , Mbaye Olivier , Bakhoum Jean-Pierre , Gaye-Seye Mame Diabou , Trellu Clément , Atanasse Coly , Aaron Jean-Jacques 
Published: December 2023

In this work, we developed an UV-visible (UV-VIS) absorption spectrometric method for the quantification of sodium diclofenac in natural waters. Several UV-VIS absorption method parameters were optimized. The maximum absorption wavelength was comprised between 276 and 292 nm, depending on the solvent, with molar absorption coefficients greater than 104 L mol-1 cm-1. The linearity of the UV-VIS calibration curves extended over one to three orders of magnitude, with correlation coefficients (R2) very close to unity. The low relative standard deviation (RSD) values indicated a good reproducibility of the measurements. Analytical applications to natural waters yielded satisfactory results with average recovery rates between 94.7 and 99.1%.
TWO-FACTOR AUTHENTICATION PROTOCOL IN ACCESS CONTROL SYSTEMS
Authors: Strelkovskaya Irina , Onatskiy Oleksiy , Yona Larysa 
Published: December 2023

Background. To ensure the protection of the biometric access control system used in unsecured communication channels, it is necessary to exclude the storage and transfer, transfer of biometric data as well as sequences generated on their basis. The paper proposes a cryptographic protocol of two-factor authentication with the zero-knowledge over the extended field GF(2m) on elliptic curves using biometric data and the private key of the user.
Objective. The aim of the article is to develop a cryptographic protocol for zero-knowledge two-factor authentication based on elliptic curves using biometric data and the user’s private key, which allows increasing cryptographic strength and reducing the duration of the authentication process.
Methods. The process of implementing zero-knowledge proof protocols is as follows: one user (proofer) can convince another user (verifier) that he has some secret without disclosing the secret itself.
Results. A cryptographic protocol for two-factor authentication with zero-knowledge over the extended field GF(2m) of elliptic curves using user biometric data is proposed, which significantly reduces the size of the protocol parameters and increases cryptographic strength (computational complexity of the breaking). There is no leakage of private key information and biometric data of the user during the execution of the zero-knowledge proof protocol.
Conclusions. The implementation of a cryptographic protocol with zero-knowledge proof two-factor authentication based on elliptic curves allows significantly reducing the size of protocol parameters and increasing the cryptographic strength (computational complexity of the breaking).
MINIMIZING HIGH-FREQUENCY SWITCHING LOSSES IN WIDEBAND GAN HEMTS FOR FLYBACK CONVERTERS
Authors: Arseniuk Dmytro , Zinkovskyi Yuri 
Published: December 2023

Background. In the realm of pulse power supplies, flyback converters play a pivotal role in efficient voltage conversion and providing electrical isolation. Typically, these converters utilize silicon transistors. However, they encounter several issues that hinder their energy efficiency and operational stability. A primary concern is the increase in switching losses at high frequencies. This is attributed to the lower switching speed and higher on-state resistance characteristic of silicon transistors. Such inefficiency leads to substantial power dissipation, thereby reducing overall efficiency. Additionally, the heat generated from these losses necessitates complex temperature control systems, increasing operational burden and affecting the reliability and longevity of the converters. Furthermore, the operational frequency of these converters is limited. While operating at higher frequencies is beneficial for reducing the size of passive components, it exacerbates the problems of switching losses and heat dissipation in silicon transistors.
Objective. This article aims to conduct a comprehensive study and optimization of flyback converters based on High Electron Mobility Transistors (HEMT) made of Gallium Nitride (GaN), focusing on minimizing losses in high-frequency switching. The study delves into the intrinsic properties of GaN HEMTs, highlighting their superior characteristics compared to traditional silicon counterparts, and emphasizes the circuit design methods for minimizing losses and their features.
Method. The research involved a detailed analysis of the switching losses of GaN HEMTs under high-frequency switching conditions. Using computer simulation models, the study examines the impact of various parameters, such as currents and voltages on the GaN transistor, power dissipation, and the output characteristics of the device with different circuit topologies on the performance and efficiency of switching.
Results. The results provide insights into the optimization strategies of topology, particularly the use of transistor gate drivers and snubber circuits, which are crucial for enhancing the overall efficiency and reliability of flyback converters.
Conclusions. The article offers an in-depth analysis into optimizing high-frequency flyback converters using GaN HEMTs, providing valuable guidance for devices requiring compact power sources, such as in small aircraft systems and telecommunications networks.
PROCESSING OPTIMIZATION OF CRAFT CHEESE CAMEMBERT TYPE
Authors: Melnik Ivan , Zaparenko Anna , Oliinyk Nataliia , Lypovyi Denis 
Published: December 2023

The article substantiates the technology of craft cheese Camembert type with the use of goat milk and dried plant products for restaurants implementation. Differences in the biological value and technological properties of goat and cow milk were analyzed. It is shown that goat milk contains more protein, fat, lactose, potassium, calcium, magnesium and iodine in comparison to cow milk. The density of goat milk is about 1.033 g∕cm3, while for cow milk this indicator varies within 1.024 and 1.037 g∕cm3. Goat milk compared to cow milk contains more retinol, thiamine, ascorbic acid and less such an allergens as αs1-casein and α-lactoalbumin, that proofs an increased biological value of goat milk. Using the methods of experimental and statistical planning, a quadratic model was obtained that adequately describes the dependence of the cheese hardness parameter on the the milk fermentation temperature and the dosage of goat milk in the recipe of Camembert type cheese. As a result of the minimization of the cheese hardness parameter according to the obtained model, it was determined that the of goat milk should be added in the recipe of craft cheese Camembert type in an amount of 35.6% of cow milk content, and the fermentation of milk should be carried out at a temperature of 36°C. These parameters allow to obtain cheese with the hardness of 13.2%. A technological scheme for the production of craft cheese Camembert type was developed, that attaches mixing of goat milk and cow milk, fermentation of milk at a temperature of 36°C, as well as the addition of dried plant products, such as thyme, rosemary and tomatoes at the stage of a clot processing . Based on the results of the evaluation of the organoleptic quality indicators of the cheese, it was found that it has the correct shape, rich and balanced taste, as well as a soft and delicate consistency, which allows to recommend it for implementation into restaurants production.
Improvement of Genetic Variation of cv Grand Naeni Bananas Through Gamma-Ray Irradiation and In Vitro Selection Using Fusaric Acid
Authors: Damayanti Fitri , Roostika Ika , Musliman Acep , Widodo Arif 
Published: December 2023

Abstract

Fusarium wilt is an important and malignant disease of bananas even in very few countries which are free from this disease. One solution that gives hope is the use of resistant varieties. Currently there are still limited resistance to fusarium. Therefore, it is necessary to do plant breeding in order to produce resistant varieties. Conventional breeding will take a long time. To accelerate the assembly of varieties, a strategy will be adopted to utilize fusarium resistant genetic material combined with mutation induction and in vitro selection. The purpose of this activity is to get the genetic diversity of bananas cv. Grand Naine through mutation induction with gamma irradiation and obtained an in vitro selection method for resistance to fusaric acid. The stages of the research included induction of mutations with gamma rays and in vitro selection with fusaric acid stress. The explants used were in vitro shoots of banana cv. Grand Naine. The gamma ray radiation doses used were 0, 5, 10, 15, 20, and 25 Gy. After irradiation, the explants were subcultured into P5 regeneration medium. In vitro selection of mutated banana shoots on culture media containing 30 mg/L fusaric acid. The results showed that banana shoots cv. Grand Naine was able to survive at the highest irradiation dose (25 Gy). The survival percentage of explants irradiated at the highest dose (25 Gy) showed a reduction in viability of up to 70%. Treatment without irradiation produced an average number of fewer normal shoots (7) but produced the most abnormal shoots (72). Irradiation of 25 Gy produced a small number of shoots but produced many perfect shoots (35). In vitro selection with fusaric acid, shoots irradiated with 20 Gy had the best resistance level compared to other irradiation doses.
Lake health assessment based on ecosystem integrity and services：A case study in Baiyangdain Lake
Authors: Zhao Zhixuan , Wei Fangfei , Wu Haotian , Yang Miao , Jin Xin , Wang Pengzhe , Wang Qing 
Published: December 2023

Abstract
Health assessment is vital for ecological protection, restoration and management of lake ecosystems. Although previous studies have established many frameworks and assessment index systems, most of them primarily focused on the single measurements of the natural status of ecosystems under external pressures. However, there is a lack of comprehensive assessment models based on the ecosystem integrity and services from the perspective of balancing the natural health status and human demand. In this study, we proposed an improve method that consider the ecosystem integrity and social services demand, which comprised five categories: physical structure, hydrology, water quality, aquatic organisms, and social service function. We used the Baiyangdian lake of the Haihe river basin in China as a case study to apply the assessment method, and the results show that (1) the overall level of lake health is “sub-healthy”, and the “sub-healthy” sample sites dominate the lake areas in the current year. (2) the index system provided a perspective to reveal the complex interactions among ecosystem integrity, services and ecosystem health status, which can characterize the health status more comprehensively compared to the single index or indicator species method. (3) the assessment method in this study is capable in evaluating the health status of Baiyangdian lake, the results can be used for decision makers to lake ecosystem protection, restoration and management.
Filler wire deflection control for Wire and Arc Additive Manufacturing
Authors: Molochkov Denys , Kulykovskyi Ruslan 
Published: December 2023

Abstract
This paper examines the issue of wire deflection in Wire and Arc Additive Manufacturing (WAAM), which leads to process instability and defects in printed geometry. The study focuses on the deflection of Alloy 601/625, Inconel 718 and SG2 wires during the deposition process. Measurements were taken to determine the relationship between wire deflection and the amount of wire used. Regression models were developed for each material to predict initial wire deflection and changes in deflection due to contact tip wear. The results showed that the deflection of Alloy 601/625 and Inconel 718 wires followed a non-linear pattern for the first 500 meters of wire, while the deflection of SG2 wire followed a nearly linear trend. The intensity of the contact tip wear is dependent on the normal contact load, which decreases as the wear increases. Based on these models, an algorithm was developed to correct the wire deflection by adjusting the tool center point coordinates. The effectiveness of the developed algorithm was verified in practice.
DRL based SFC Orchestration in SDN/NFV Environments subject to Transient Unavailability
Authors: Escheikh Mohamed , Taktak wiem , Barkaoui Kamel 
Published: December 2023

Abstract

We address in this paper how complex and dynamic environments characterized by variable limited capacities and subject to transient unavailability may pose significant challenges for Deep Reinforcement Learning (DRL) agent. The investigation concerns the context of Service Function Chaining (SFC) orchestration problem in Software-Defined Networking (SDN) and Network Function Virtualization (NFV) based environments using DRL approach, implemented through Deep Q-Network (DQN), and aiming to maximize Quality of Experience (QoE) while meeting Quality of Service (QoS) constraints. We show through numerical results how limited capacity in Physical Substrate Network (PSN) complicates the training process in terms of finding suitable compromise between performance and convergence. We highlight also how replay buffer may mitigate transient
unavailability of PSN nodes and what are the limits of such a solution when the unavailability becomes more prolonged in time or more severe (simultaneous unavailability of more than one node).
Development of a Cyclic Fracture Experiment for Characterization of High-Performance Asphalt Concrete Mixes
Authors: Rahman Nafiur , Castro Samuel , Beheshti Masih , Vedula Naaga Viswanath , Noorvand Hossein , Ozer Hasan 
Published: December 2023

Abstract
Cracking resistance of asphalt concrete (AC) is typically determined using monotonic fracture experiments using load-line displacement or crack mouth opening displacements (CMOD) except low or high cycle fatigue experiments. The outcome of the monotonic fracture tests is a single energy-based or index parameter limiting the ability to distinguish a range of mixes with different stiffnesses and viscoelastic characteristics. On the other hand, high cycle fatigue, such as beam fatigue or low cycle fatigue experiments, such as Texas Overlay test, are time consuming and can sometimes be less repeatable. A Cyclic CMOD Control fracture (C3F) testing protocol was developed to assess cracking resistance of various AC mixtures at lower temperatures. The cyclic testing protocol was incorporated with prescribed and limited number of cycles to parametrically assess responses of the specimens to loading and unloading cycles. Various fracture parameters could be extracted from the testing protocol to gain a comprehensive characterization of an AC mix during crack initiation and propagation. A much richer assessment of AC mixes’ cracking resistance can be achieved to include fracture energy, viscoelastic recovery characteristics, critical tip opening displacement, and fracture toughness. Specimen responses were coupled with physical crack growth via a vision-based system to trace crack propagation. The test method was applied to the two different applications for AC mixes commonly used to enhance cracking resistance. The results show the benefits of polymer modification at the crack initiation stages through recovered energy and delayed cracking, whereas fiber reinforcement’s role at the steady state crack propagation stage.
Root disturbance effects of diverse halophytes on soil nutrient elements and salt ions in intertidal ecotone of the Yellow River Estuary wetland
Authors: Sun Debin , Guan Bo , Li Yunzhao , Yu Junbao , Qu Fanzhu , Yang Jisong , Wang Xuehong , Li Xue , Zhou Di 
Published: December 2023

Abstract
Four representative halophytes of Tamarix chinensis (Tc), Phragmites australis (TPa), Suaeda salsa (Ss) and Spartina alterniflora (Sa) in the Yellow River Estuary wetland were selected to clarify the root disturbance effects on soil nutrient elements, salt ions and their stoichiometric ratios. The results showed that the average TOC content of Tc, TPa, Ss, and Sa in the rhizosphere (RS) group were 5.19, 2.15, 2.05, and 2.14 times of those in the non-rhizosphere (CK) group, respectively. TN content of Tc in the RS group was about 3.44 times of the CK group. The average soil pH and salinity reduced by 3.60% and 41.35%, respectively, due to the root disturbance of Tc. Soil ions including K+, Ca2+, Mg2+, Na+, Cl- and SO42- reduced by 33.86%-62.86%. The root disturbance of TPa reduced soil pH and salinity by 1.09% and 35.47%, respectively, and soil ions reduced by 16.93%-46.85%. However, the root disturbance effects in Sa and Ss were not obvious. The results of Mantel test and PCA demonstrated that the root disturbance diversified the soil characteristics. The disturbance of roots played a crustal role in affecting the spatial heterogeneity of soil properties in the coastal wetlands above the intertidal zone (Tc and TPa), and its effect was greatly weakened below the intertidal zone (Sa and Ss). These findings are important for understanding how halophytes can impact soil nutrient levels and salt concentrations in coastal wetlands, which is crucial for effective management and restoration efforts.
Does the day 3 embryo cell number affect pregnancy and neonatal outcomes following single blastocyst transfer from frozen embryo transfer cycles?
Authors: Tao Lin-Lin , Zheng Bo , Li Guo-Zhen , Geng Ya-Song , Yang Zhi-Wei , Dai Hao-Yang , Wang Shu-Song , Dai Fang-fang 
Published: December 2023

Abstract
Background:The aim of this retrospective cohort study was to assess the impact of day 3 embryo cell number on the clinical pregnancy and neonatal outcomes of single blastocyst transfer in frozen embryo transfer (FET) cycles.
Methods:The study included 624 day 5 single blastocyst FET cycles conducted between January 2017 and December 2022. Patients were categorized into four groups based on the cell number on day 3: 51 cycles in the <7-cell group, 378 cycles in the 7~9-cell group, 121 cycles in the 10~13-cell group, and 74 cycles in the >13-cell group. The study compared the clinical pregnancy outcomes and neonatal outcomes among the four groups.
Results: The clinical pregnancy rates of blastocysts in the 7~9-cell group and the 10~13-cell group were significantly higher than those in the <7-cell group. Additionally, the live birth rates in the 7~9-cell group were significantly higher than those in the <7-cell group. While the clinical pregnancy and live birth rates in the >13-cell group decreased compared to the 7~9-cell group and the 10~13-cell group, the differences were not significant. There were no significant differences in the clinical pregnancy rate and live birth rate between the 10~13-cell group and the 7~9-cell group. Additionally, there were no significant differences in the rates of ectopic pregnancy cycles, miscarriage, monozygotic twins, premature delivery, gestational week of delivery, male/female ratio, and birth weight among the four groups.After adjusting for potential confounding factors, the <7-cell group was associated with lower clinical pregnancy and live birth rates compared to the 7~9-cell group and the 10~13-cell group. The clinical pregnancy and live birth rates of the >13-cell group were lower than those of the 7~9-cell group. Subgroup analysis revealed significant differences in the clinical pregnancy and live birth rates among the overall groups for individuals aged ≤30, and the insemination pattern of ICSI.
Conclusion:
When performing single blastocyst transfer in FET cycles, blastocysts with 7~13 cells on day 3 should be prioritized, to enhance clinical pregnancy outcome, especially when patients are aged ≤30 years, and when the insemination pattern is ICSI.