bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dormancy and double‐activation strategy for construction of high‐performance mixed‐matrix membranes
Authors: Li Shuo , Han Wei‐Yao , Wang Zhao‐Xu , Sun Yu‐Jie , Zheng Zilong , Yin Ming‐Jie , Liu Shaomin , An Quan‐Fu 
Published: November 2023

AbstractMixed‐matrix membranes (MMMs) have the potential for energy‐efficient gas separation by matching the superior mass transfer and anti‐plasticization properties of the fillers with processability and scaling up features of the polymers. However, construction of high‐performance MMMs has been prohibited due to low filler‐loading and the existence of interfacial defects. Here, high MOF‐loaded, i.e., 55 wt %, MMMs are developed by a ‘dormancy and double‐activation’ (DDA) strategy. High MOF precursor concentration suppresses crystallization in the membrane casting solution, realizing molecular level mixing of all components. Then, the polymeric matrix was formed with uniform encapsulation of MOF nutrients. Subsequently, double‐activation was employed to induce MOF crystallization: the alkali promotes MOFs nucleation to harvest small porous nanocrystals while excessive ligands activate the metal ions to enhance the MOFs conversion. As such, quasi‐semi‐continuous mass transfer channels can be formed in the MMMs by the connected MOFs nanocrystals to boost the gas permeability. The optimized MMM shows significantly ameliorated CO2 permeability, i.e., 2841 Barrer, five‐fold enhancement compared with pristine polymer membrane, with a good CO2/N2 selectivity of 36. Besides, the nanosized MOFs intensify their interaction with polymer chains, endowing the MMMs with good anti‐plasticization behaviour and stability, which advances practical application of MMMs in carbon capture.
(3+2) Annulation of 4‐Acetoxy Allenoate with Aldimine Enabled by AgF‐Assisted P(III)/P(V) Catalysis
Authors: Qian Jinlong , Zhou Lijin , Peng Rouxuan , Tong Xiaofeng 
Published: November 2023

AbstractA phosphine‐catalyzed (3+2) annulation of 4‐acetoxy allenoate and aldimine with the assistance of AgF is described. The success of this reaction hinges on the metathesis between the enolate‐phosphonium zwitterion and AgF, leading to a key intermediate comprising of silver enolate and a fluorophosphorane P(V)‐moiety. The former is able to undergo a Mannich reaction with aldimine, whereas the latter initiates a cascade sequence of AcO‐elimination/aza‐addition, thus furnishing the P(III)/P(V) catalysis. By taking advantage of the silver enolate, a preliminary attempt at an asymmetric variant was conducted with the combination of an achiral phosphine catalyst and a chiral bis(oxazolinyl)pyridine ligand (PyBox), giving moderate enantioselectivity.
Fully Aromatic Self‐Assembled Hole‐Selective Layer toward Efficient Inverted Wide‐Bandgap Perovskite Solar Cells with Ultraviolet Resistance
Authors: Li Chi , Zhang Zilong , Zhang Huifeng , Yan Wenlong , Li Yuheng , Liang Lusheng , Yu Wei , Yu Xuteng , Wang Yao , Yang Ye , Nazeeruddin Mohammad Khaja , Gao Peng 
Published: November 2023

AbstractUltraviolet‐induced degradation has emerged as a critical stability concern impeding the widespread adoption of perovskite solar cells (PSCs), particularly in the context of phase‐unstable wide‐band gap perovskite films. This study introduces a novel approach by employing a fully aromatic carbazole‐based self‐assembled monolayer, denoted as (4‐(3,6‐dimethoxy‐9H‐carbazol‐9‐yl)phenyl)phosphonic acid (MeO‐PhPACz), as a hole‐selective layer (HSL) in inverted wide‐band gap PSCs. Incorporating a conjugated linker plays a pivotal role in promoting the formation of a dense and highly ordered HSL on substrates, facilitating subsequent perovskite interfacial interactions, and fostering the growth of uniform perovskite films. The high‐quality film could effectively suppress interfacial non‐radiative recombination, improving hole extraction/transport efficiency. Through these advancements, the optimized wide‐band gap PSCs, featuring a band gap of 1.68 eV, attain an impressive power conversion efficiency (PCE) of 21.10 %. Remarkably, MeO‐PhPACz demonstrates inherent UV resistance and heightened UV absorption capabilities, substantially improving UV resistance for the targeted PSCs. This characteristic holds significance for the feasibility of large‐scale outdoor applications.
Multi‐d Electron Synergy in LaNi1‐xCoxRu Intermetallics Boosts Electrocatalytic Hydrogen Evolution
Authors: Shen Shijie , Zhang Huanhuan , Song Kai , Wang Zongpeng , Shang Tongtong , Gao Ang , Zhang Qinghua , Gu Lin , Zhong Wenwu 
Published: November 2023

AbstractDespite the fact that d‐band center theory links the d electron structure of transition metals to their catalytic activity, it is yet unknown how the synergistic effect of multi‐d electrons impacts catalytic performance. Herein, novel LaNi1‐xCoxRu intermetallics containing 5d, 4d, and 3d electrons were prepared. In these compounds, the 5d orbital of La transfers electrons to the 4d orbital of Ru, which provides adsorption sites for H*. The 3d orbitals of Ni and Co interact with the 5d and 4d orbitals to generate an anisotropic electron distribution, which facilitates the adsorption and desorption of OH*. The synergistic effect of multi‐d electrons ensures efficient catalytic activity. The optimized LaNi0.5Co0.5Ru has an overpotential of 43mV at 10 mA cm−2 for alkaline electrocatalytic hydrogen evolution reaction. Beyond offering a variety of new electrocatalysts, this work reveals the multi‐d electron synergy in promoting catalytic reaction.
Achieving the High Capacity and High Stability of Li‐Rich Oxide Cathode in Garnet‐Based Solid‐State Battery
Authors: Chen Butian , Zhang Jicheng , Wong Deniz , Wang Tenghui , Li Taiguang , Liu Chong , Sun Limei , Liu Xiangfeng 
Published: November 2023

AbstractSolid‐state batteries (SSBs) based on Li‐rich Mn‐based oxide (LRMO) cathodes attract much attention because of their high energy density as well as high safety. But their development was seriously hindered by the interfacial instability and inferior electrochemical performance. Herein, we design a three‐dimensional foam‐structured GaN−Li composite anode and successfully construct a high‐performance SSB based on Co‐free Li1.2Ni0.2Mn0.6O2 cathode and Li6.5La3Zr1.5Ta0.5O12 (LLZTO) solid electrolyte. The interfacial resistance is considerably reduced to only 1.53 Ω cm2 and the assembled Li symmetric cell is stably cycled more than 10,000 h at 0.1–0.2 mA cm−2. The full battery shows a high initial capacity of 245 mAh g−1 at 0.1 C and does not show any capacity degradation after 200 cycles at 0.2 C (≈100 %). The voltage decay is well suppressed and it is significantly decreased from 2.96 mV/cycle to only 0.66 mV/cycle. The SSB also shows a very high rate capability (≈170 mAh g−1 at 1 C) comparable to a liquid electrolyte‐based battery. Moreover, the oxygen anion redox (OAR) reversibility of LRMO in SSB is much higher than that in liquid electrolyte‐based cells. This study offers a distinct strategy for constructing high‐performance LRMO‐based SSBs and sheds light on the development and application of high‐energy density SSBs.
A Pyrene‐Fused Dimerized Acceptor for Ternary Organic Solar Cells with 19% Efficiency and High Thermal Stability
Authors: Liu Xucong , Zhang Zhou , Wang Chao , Zhang Cuifen , Liang Shijie , Fang Haisheng , Wang Bo , Tang Zheng , Xiao Chengyi , Li Weiwei 
Published: November 2023

AbstractA pyrene‐fused dimerized electron acceptor has been successfully synthesized and subsequently incorporated as the third component in ternary organic solar cells (OSCs). Diverging from the traditional dimerized acceptors with a linear configuration, this novel electron acceptor displays a distinctive “butterfly‐like” structure, comprising two Y‐acceptors as wings fused with a pyrene‐based backbone. The extended π‐conjugated backbone and the electron‐donating nature of pyrene enable the new acceptor to show low solubility, elevated glass transition temperature (Tg), and low‐lying frontier energy levels. Consequently, the new dimerized acceptor seamlessly integrates as the third component into ternary OSCs, enhancing electron transporting properties, reducing non‐radiative voltage loss, and elevating open‐circuit voltage. These merits have enabled the ternary OSCs to show an exceptional efficiency of 19.07%, a marked improvement compared to the 17.6% attained in binary OSCs. More importantly, the high Tg exhibited by the pyrene‐fused electron acceptor helps to stabilize the morphology of the photoactive layer thermal‐treated at 70 °C, retaining 88.7% efficiency over 600 hours. For comparison, binary OSCs experience a decline to 73.7% efficiency after the same duration. These results indicate that the “butterfly‐like” design and the incorporation of a pyrene unit is a promising strategy in the development of dimerized electron acceptors for OSCs.
Modulating Skeletons of Covalent Organic Framework for High‐Efficiency Gold Recovery
Authors: Liu Minghao , Jiang Di , Fu Yubin , Zheng Chen George , Bi Shuai , Ding Xuesong , He Jun , Han Bao‐Hang , Xu Qing , Zeng Gaofeng 
Published: November 2023

AbstractCovalent organic frameworks (COFs) have attracted considerable attention as adsorbents for capturing and separating gold from electronic wastes. To enhance the binding capture efficiency, constructing hydrogen‐bond nanotraps along the pore walls was one of the most widely adopted approaches. However, the development of absorbing skeletons was ignored due to the weak binding ability of the gold salts (Au). Herein, we demonstrated skeleton engineering to construct highly efficiently absorbs for Au capture. The strong electronic donating feature of diarylamine units enhanced the electronic density of binding sites (imine‐linkage) and thus resulted in high capacities over 1750 mg g−1 for all three COFs. Moreover, the absorbing performance was further improved via the ionization of diarylamine units. The ionic COF achieved 90 % of the maximal adsorption capacity, 1.63 times of that from the charge‐neutral COF within ten minutes, and showed remarkable uptakes of 1834 mg g−1, exceptional selectivity (97.45 %) and cycling stability. The theoretical calculation revealed the binding sites altering from imine bonds to ionic amine sites after ionization of the frameworks, which enabled to bind the AuCl4− via coulomb force and contributed to enhanced absorbing kinetics. This work inspires us to design molecular/ionic capture based on COFs.
Amino Acids Fueling Fibroblast‐Like Synoviocyte Activation and Arthritis By Regulating Chemokine Expression and Leukocyte Migration
Authors: Karonitsch Thomas , Saferding Victoria , Kieler Markus , von Dalwigk Karolina , Tosevska Anela , Heller Gerwin , Dellinger Mirjam , Niederreiter Birgit , Kartnig Felix , Steiner Carl W. , Georgel Philippe , Kiener Hans P. , Smolen Josef S. , Korb‐Pap Adelheid , Bonelli Michael , Aletaha Daniel , Blüml Stephan 
Published: November 2023

ObjectiveWe analyzed the impact of amino acid (AA) availability on the inflammatory response in arthritis.MethodsWe stimulated rheumatoid arthritis (RA) fibroblast‐like synoviocytes (FLSs) with tumor necrosis factor (TNF) in the presence or absence of proteinogenic AAs and measured their response by QuantSeq 3′ messenger RNA sequencing, quantitative polymerase chain reaction, and enzyme‐linked immunosorbent assay. Signal transduction events were determined by Western blot. We performed K/BxN serum transfer arthritis in mice receiving a normal and a low‐protein diet and analyzed arthritis clinically and histologically.ResultsDeprivation of AAs decreased the expression of a specific subset of genes, including the chemokines CXCL10, CCL2, and CCL5 in TNF‐stimulated FLSs. Mechanistically, the presence of AAs was required for the TNF‐induced activation of an interferon regulatory factor 1 (IRF1)‐STAT1 signaling circuit that drives the expression of chemotactic factors. The expression of IRF1 and the IRF1‐dependent gene set in FLSs was highly correlated with the presence of inflammatory cells in human RA, emphasizing the important role of this AA‐dependent pathway in inflammatory cell recruitment to the synovial tissue. Finally, we show that mice receiving a low‐protein diet expressed less IRF1 in the inflamed synovium and consequently developed reduced clinical and histologic signs of arthritis.ConclusionAA deprivation reduces the severity of arthritis by suppressing the expression of IRF1‐STAT1–driven chemokines, which are crucial for leukocyte recruitment to the arthritic joint. Overall, our study provides novel insights into critical determinants of inflammatory arthritis and may pave the way for dietary intervention trials in RA.image
Utilisation and impact of predict prostate on decision‐making among clinicians and patients in a specialist tertiary referral centre: A retrospective cohort study
Authors: Pandiaraja Madhumitha , Pryle Isolde , West Leah , Gardner Lucy , Shallcross Olivia , Tay June , Shah Nimish , Gnanapragasam Vincent , Lamb Benjamin W. 
Published: November 2023

AbstractBackgroundPatients with intermediate‐risk prostate cancer are faced with the decision of whether to undergo radical treatment. Decision‐making aids, such as Predict Prostate, can empower both clinicians and patients to make treatment decisions with personalised information, but their impact on multi‐disciplinary team (MDT) decision‐making and uptake of radical treatment remains unknown.ObjectiveThe objective of this study is to assess the utilisation and utility of Predict Prostate in informing treatment decisions for patients with intermediate‐risk prostate cancer.Patients and MethodsA retrospective cohort study was conducted in Cambridge University Hospitals (CUH) of patients referred to the prostate cancer specialist multi‐disciplinary team (pcSMDT) and robotic prostatectomy clinic (ROPD) between September 2019 and August 2021 for consideration of radical prostatectomy (RARP). Data on patient characteristics, use of PredictProstate and management decisions were collected from the Epic electronic medical record (EMR) of 839 patients, of whom 386 had intermediate‐risk prostate cancer.ResultsThe use of Predict Prostate at the pcSMDT increased in the second half of the study period (34.5% vs. 23.8%, p < 0.001). The use of Predict Prostate was associated with an increased likelihood of attending ROPD for men with CPG2 prostate cancer (OR = 2.155, 95% CI = 1.158–4.013, p = 0.015) but a reduced likelihood of proceeding with RARP for men with CPG2 (OR = 0.397, 95% CI = 0.209–0.753, p = 0.005) and CPG3 (OR = 0.305, 95% CI = 0.108–0.861, p = 0.025) prostate cancer.ConclusionOur study showed that the use of Predict Prostate for patients with intermediate‐risk prostate cancer is associated with increased attendance at specialist surgical clinic and a reduced chance of undergoing radical prostate surgery.
Reconstruction of tracheal window‐shape defect by 3D printed polycaprolatone scaffold coated with Silk Fibroin Methacryloyl
Authors: Shan Yibo , Shen Zhiming , Lu Yi , Zhu Jianwei , Sun Fei , Chen Wenxuan , Yuan Lei , Shi Hongcan 
Published: November 2023

AbstractIn this study, we aimed to utilize autologous tracheal epithelia and BMSCs as the seeding cells, utilize PCL coated with SilMA as the hybrid scaffold to carry the cells and KGN, which can selectively stimulate chondrogenic differentiation of BMSCs. This hybrid tracheal substitution was carried out to repair the tracheal partial window‐shape defect. Firstly, SilMA with the concentration of 10%, 15% and 20% was prepared, and the experiment of swelling and degradation was performed. With the increase of the concentration, the swelling ratio of SilMA decreased, and the degradation progress slowed down. Upon the result of CCK‐8 test and HE staining of 3D co‐culture, the SilMA with concentration of 20% was selected. Next, SilMA and the cells attached to SilMA were characterized by SEM. Furthermore, in vitro cytotoxicity test shows that 20% SilMA has good cytocompatibility. The hybrid scaffold was then made by PCL coated with 20% SilMA. The mechanical test shows this hybrid scaffold has better biomechanical properties than native trachea. In vivo tracheal defect repair assays were conducted to evaluate the effect of the hybrid substitution. H&E staining, IHC staining and IF staining showed that this hybrid substitution ensured the viability, proliferation and migration of epithelium. However, it is sad that the results of chondrogenesis were not obvious. This study is expected to provide new strategies for the fields of tracheal replacement therapy needing mechanical properties and epithelization.
Pharmacological Activities of Rhododendron afghanicum; an Endemic Species of Khyber Pakhtunkhwa, Pakistan
Authors: Alam Khan , Ahmad Nadeem , Ahmad Imran , Nafees Muhammad 
Published: November 2023

AbstractMajority of different kinds of metabolites having therapeutic characteristics are thought to be stored in medicinal plants. So, the present study was aimed to explore the crude extract of leaves and stem of R. afghanicum for phytochemical screening and various pharmacological activities. Toxicological studies at 100 mg/kg showed 60 % mortality where its safe dose level was 90 mg/kg. Phytochemical screening revealed the presence of alkaloids, glycosides, flavonoids and tannins in both extracts. Bacterial strains were susceptible to (RLEt) and (RLM) crude extracts except Staphylococcus aureus. RSM showed maximum anti‐inflammatory activity (20.16 %) followed by RSEt (20.14 %) where lowest activity was displayed by RLEt (18.46 %). Phytotoxic activity showed a substantial dose‐dependent phyto‐inhibition of Lemna minor. An outstanding cytotoxic potential was displayed with LD50 values of 9.46 and 13.03 μg/ml in both stem extracts. RLEt demonstrated a dose‐dependent pain relief at 30, 60 and 90 mg/kg which was 31 %, 40 % and 52 % respectively. A considerable spasmolytic action was observed by the shrinkage of jejunum muscle in albino mice. RLEt at 1000 ppm showed (17 mm) and RLM at 1000 ppm showed (16 mm) zone of inhibition against Aspergillus niger. These findings support and corroborate the traditional applications of R. afghanicum for treating digestive, analgesic and inflammatory ailments.
The effect of (neo)adjuvant chemotherapy on long‐term survival outcomes in patients with invasive lobular breast cancer treated with endocrine therapy: A retrospective cohort study
Authors: Öztekin Selin , Hooning Maartje J. , van Deurzen Carolien H. M. , Dietvorst Anne‐Marie H. P. , Drooger Jan C. , Kitzen Jos J. E. M. , Martens John W. M. , van der Padt‐Pruijsten Annemieke , Vastbinder Mijntje B. , Zuetenhorst Hanneke , Heemskerk‐Gerritsen Bernadette A. M. , Jager Agnes 
Published: November 2023

AbstractBackgroundDespite histological and molecular differences between invasive lobular carcinoma (ILC) and invasive carcinoma of no special type, according to national treatment guidelines no distinction is made regarding the use of (neo)adjuvant chemotherapy. Studies on the long‐term outcome of chemotherapy in patients with ILC are scarce and show inconclusive results.MethodsAll patients with estrogen receptor (ER)–positive, human epidermal growth factor receptor 2 (HER2)–negative ILC with an indication for chemotherapy treated with adjuvant endocrine therapy were selected from the Erasmus Medical Center Breast Cancer database. Cox proportional hazards models were used to estimate the effect of chemotherapy on recurrence‐free survival (RFS), breast cancer–specific survival (BCSS), and overall survival (OS).ResultsA total of 520 patients were selected, of whom 379 were treated with chemotherapy and 141 were not. Patients in the chemotherapy group were younger (51 vs. 61 years old; p < .001), had a higher T status (T3+, 33% vs. 14%; p < .001), and more often had lymph node involvement (80% vs. 49%; p < .001) in comparison to the no‐chemotherapy group. After adjusting for confounders, chemotherapy treatment was not associated with better RFS (hazard ratio [HR], 1.20; 95% confidence interval [CI], 0.63–2.31), BCSS (HR, 1.24; 95% CI, 0.60–2.58), or OS (HR, 0.97; 95% CI, 0.56–1.66). This was also reflected by adjusted Cox survival curves in the chemotherapy versus no‐chemotherapy group for RFS (75% vs. 79%), BCSS (80% vs. 84%), and OS (72% vs. 71%).ConclusionsChemotherapy is not associated with improved RFS, BCSS, or OS for patients with ER+/HER2− ILC treated with adjuvant endocrine therapy and with an indication for chemotherapy.
Artificial flowers as a tool for investigating multimodal flower choice in wild insects
Authors: Chapman Kathryn M. , Richardson Freya J. , Forster Caitlyn Y. , Middleton Eliza J. T. , White Thomas E. , Burke Paul F. , Latty Tanya 
Published: November 2023

AbstractFlowers come in a variety of colours, shapes, sizes and odours. Flowers also differ in the quality and quantity of nutritional reward they provide to entice potential pollinators to visit. Given this diversity, generalist flower‐visiting insects face the considerable challenge of deciding which flowers to feed on and which to ignore. Working with real flowers poses logistical challenges due to correlations between flower traits, maintenance costs and uncontrolled variables. Here, we overcome this challenge by designing multimodal artificial flowers that varied in visual, olfactory and reward attributes. We used artificial flowers to investigate the impact of seven floral attributes (three visual cues, two olfactory cues and two rewarding attributes) on flower visitation and species richness. We investigated how flower attributes influenced two phases of the decision‐making process: the decision to land on a flower, and the decision to feed on a flower. Artificial flowers attracted 890 individual insects representing 15 morphospecies spanning seven arthropod orders. Honeybees were the most common visitors accounting for 46% of visitors. Higher visitation rates were driven by the presence of nectar, the presence of linalool, flower shape and flower colour and was negatively impacted by the presence of citral. Species richness was driven by the presence of nectar, the presence of linalool and flower colour. For hymenopterans, the probability of landing on the artificial flowers was influenced by the presence of nectar or pollen, shape and the presence of citral and/or linalool. The probability of feeding increased when flowers contained nectar. For dipterans, the probability of landing on artificial flowers increased when the flower was yellow and contained linalool. The probability of feeding increased when flowers contained pollen, nectar and linalool. Our results demonstrate the multi‐attribute nature of flower preferences and highlight the usefulness of artificial flowers as tools for studying flower visitation in wild insects.