bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crossing fibers may underlie the dynamic pulling forces of muscles that attach to cartilage at the tip of the nose
Authors: Hur Mi-Sun , Lee Seunggyu , Jung Han-Sung , Schneider Richard A. 
Published: November 2023

AbstractThe present study used microdissection, histology, and microcomputed tomography (micro-CT) with the aims of determining the prevalence and patterns of the depressor septi nasi (DSN) and orbicularis oris (OOr) muscles attached to the footplate of the medial crus (fMC) of the major alar cartilage, focusing on their crossing fibers. The DSN and OOr attached to the fMC of the major alar cartilage were investigated in 76 samples from 38 embalmed Korean adult cadavers (20 males, 18 females; mean age 70 years). The DSN, OOr, or both were attached to the fMC. When the DSN ran unilaterally or was absent, some OOr fibers ascended to attach to the fMC instead of the DSN in 20.6% of the samples. Crossing fibers of the DSN or OOr attached to the fMC were found in 82.4% of the samples. Bilateral and unilateral crossing fibers were found in 32.4% and 50.0%, respectively, and no crossing fibers were found in 17.6%. The DSN and OOr that attached to the fMC could be categorized into six types according to presence of the DSN and the crossing patterns of the DSN and OOr. Anatomical findings of the DSN and OOr that attached to the fMC were confirmed in histology and micro-CT images. These findings offer insights on anatomical mechanisms that may underlie the dynamic pulling forces generated by muscles that attach to the fMCs and on evolutionary variation observed in human facial expressions. They can also provide useful information for guiding rhinoplasty of the nasal tip.
The relationship between myodural bridge, atrophy and hyperplasia of the suboccipital musculature, and cerebrospinal fluid dynamics
Authors: Yang Heng , Wei Xiao-Song , Gong Jin , Du Xue-Mei , Feng Hong-Bo , Su Chang , Gilmore Campbell , Yue Chen , Yu Sheng-Bo , Li Chan , Sui Hong-Jin 
Published: November 2023

AbstractThe Myodural Bridge (MDB) is a physiological structure that is highly conserved in mammals and many of other tetrapods. It connects the suboccipital muscles to the cervical spinal dura mater (SDM) and transmits the tensile forces generated by the suboccipital muscles to the SDM. Consequently, the MDB has broader physiological potentials than just fixing the SDM. It has been proposed that MDB significantly contributes to the dynamics of cerebrospinal fluid (CSF) movements. Animal models of suboccipital muscle atrophy and hyperplasia were established utilizing local injection of BTX-A and ACE-031. In contrast, animal models with surgical severance of suboccipital muscles, and without any surgical operation were set as two types of negative control groups. CSF secretion and reabsorption rates were then measured for subsequent analysis. Our findings demonstrated a significant increase in CSF secretion rate in rats with the hyperplasia model, while there was a significant decrease in rats with the atrophy and severance groups. We observed an increase in CSF reabsorption rate in both the atrophy and hyperplasia groups, but no significant change was observed in the severance group. Additionally, our immunohistochemistry results revealed no significant change in the protein level of six selected choroid plexus-CSF-related proteins among all these groups. Therefore, it was indicated that alteration of MDB-transmitted tensile force resulted in changes of CSF secretion and reabsorption rates, suggesting the potential role that MDB may play during CSF circulation. This provides a unique research insight into CSF dynamics.
A novel simulador for agile and graphical modeling of surface plasmon resonance based sensors
Authors: Gomes Julio C. M. , Oliveira Leiva C. 
Published: November 2023

AbstractSurface plasmon resonance (SPR) sensor is a consolidated technology for analysis of biomolecular interaction, largely applied in biology and pharmaceutical research. The simulation of the surface plasmon optical excitation response is an important step in the development process of SPR based sensors. The structure, design and configuration of the desired sensor benefits from a previous simulated analyses of the generated responses, defining operational conditions and feasibility of the selected materials to composed the optical coupling layers. Here an online web-based SPR sensor’s simulator is presented. With a visual-oriented interface, enable drag & drop actions to easily and quickly model a variety of sensor arrangements. Presenting an embedded materials database for metals, glasses, 2D materials, nanoparticles, polymers, and custom substances, the simulator enables flexible configuration for sensors operating in angular and spectral modes, as well as localized SPR. The light propagation through the multilayer of materials is presented in terms of Fresnel coefficients, which are graphically displayed. The so-called SPR morphology parameters can be visualized. Moreover, sensor dynamic behavior could be knowledge by a Sensorgram simulation. Localized surface plasmon resonance (LSPR) in homogeneous and spherical nanoparticles is also present in the simulator. Simulated scenario’s in various configurations, designs and excitation were performed and compare with other simulator. The proposed simulator guarantees comparable results with low-code, agile, and intuitive flow of execution.
Desmoplasia in cervical cancer is associated with a more aggressive tumor phenotype
Authors: Wolf Benjamin , Weydandt Laura , Dornhöfer Nadja , Hiller Grit Gesine Ruth , Höhn Anne Kathrin , Nel Ivonne , Jain Rakesh K. , Horn Lars-Christian , Aktas Bahriye 
Published: November 2023

AbstractIn cancer of the uterine cervix, the role of desmoplasia, i.e., peritumoral stromal remodeling characterized by fibroblast activation and increased extracellular matrix deposition, is not established. We conducted a retrospective cohort study based on data from 438 patients who had undergone surgical treatment for cervical cancer as part of the prospective Leipzig Mesometrial Resection study between 1999 and 2021. Using non-parametric tests, Kaplan–Meier plotting, and Cox regression modeling, we calculated the prognostic impact of desmoplasia and its association with other risk factors. Desmoplasia was present in 80.6% of cases and was associated with a higher frequency of lymphovascular space involvement (76.5 vs. 56.5%, p < 0.001) and venous infiltration (14.4 vs. 2.4%, p < 0.001). Lymph node metastasis (23.0 vs. 11.8%, p < 0.05) and parametrial involvement (47.3 vs. 17.6%, p < 0.0001) were also more common in patients with desmoplasia. The presence of desmoplasia was associated with inferior overall (80.2% vs. 94.5% hazard ratio [HR] 3.8 [95% CI 1.4–10.4], p = 0.002) and recurrence-free survival (75.3% vs. 87.3%, HR 2.3 [95% CI 1.2–4.6], p = 0.008). In addition, desmoplasia was associated with significantly less peritumoral inflammation (rho − 0.43, p < 0.0001). In summary, we link desmoplasia to a more aggressive phenotype of cervical cancer, reduced peritumoral inflammation, and inferior survival.
Evaluating the prospective crown-root ratio after extrusion and crown lengthening procedures in vitro
Authors: Bruhnke Maria , Voß Isabelle , Sterzenbach Guido , Beuer Florian , Naumann Michael 
Published: November 2023

AbstractFor restoration of extensively damaged teeth preprosthetic treatment measures are necessary. Crown lengthening and extrusion affect the prospective crown-root ratio (CRR). The subject of this in vitro study was to compute CRRs for both treatment approaches. 120 human maxillary central extracted incisors were measured. Measurements were calculated for five treatment groups: C (control), E-2 mm (extrusion of 2 mm), E-4 mm (extrusion of 4 mm), CL-2 mm (crown lengthening of 2 mm), and CL-4 mm (crown lengthening of 4 mm). Tooth (TL), root (RL), and crown lengths (CL) were measured from mesial (m) and facial (f) cemento-enamel junction (CEJ), and respective anatomic (CRR) and effective crown-root ratios (eCRR) were calculated. Following CRR values were computed for C: CRR-m = 0.4 ± 0.1, CRR-f = 0.7 ± 0.1. All crown-root ratios were lower (more favourable) for extrusion compared to crown lengthening (p < 0.001). ECRRs were higher than anatomic CRRs. CRR at mesial CEJ was significantly lower than CRR with facial CEJ as reference (p < 0.001). Mesial measurement-based calculations of CRR typically based on radiographic images should be interpreted with caution as they underestimate the eCRR. CRR can be expected as lower, i.e. more favourable, when teeth are extruded than crown lengthened.
In vitro and in silico prediction of antibacterial interaction between essential oils via graph embedding approach
Authors: Yabuuchi Hiroaki , Hayashi Kazuhito , Shigemoto Akihiko , Fujiwara Makiko , Nomura Yuhei , Nakashima Mayumi , Ogusu Takeshi , Mori Megumi , Tokumoto Shin-ichi , Miyai Kazuyuki 
Published: November 2023

AbstractEssential oils contain a variety of volatile metabolites, and are expected to be utilized in wide fields such as antimicrobials, insect repellents and herbicides. However, it is difficult to foresee the effect of oil combinations because hundreds of compounds can be involved in synergistic and antagonistic interactions. In this research, it was developed and evaluated a machine learning method to classify types of (synergistic/antagonistic/no) antibacterial interaction between essential oils. Graph embedding was employed to capture structural features of the interaction network from literature data, and was found to improve in silico predicting performances to classify synergistic interactions. Furthermore, in vitro antibacterial assay against a standard strain of Staphylococcus aureus revealed that four essential oil pairs (Origanum compactum—Trachyspermum ammi, Cymbopogon citratus—Thujopsis dolabrata, Cinnamomum verum—Cymbopogon citratus and Trachyspermum ammi—Zingiber officinale) exhibited synergistic interaction as predicted. These results indicate that graph embedding approach can efficiently find synergistic interactions between antibacterial essential oils.
Anoikis-related genes signature development for clear cell renal cell carcinoma prognosis and tumor microenvironment
Authors: Jiang Yinglei , Wang Ying , Wang Zhengyan , Zhang Yinzhen , Hou Yulong , Wang Xukai 
Published: November 2023

AbstractClear cell renal cell carcinoma (ccRCC) is one of the most common primary malignancies of the urinary tract, highly heterogeneous, and increasing in incidence worldwide. Anoikis is a specific type of programmed cell death in which solid tumor cells or normal epithelial cells that do not have metastatic properties lose adhesion to the extracellular matrix or undergo inappropriate cell adhesion-induced apoptosis. Anoikis is thought to play a critical role in tumorigenesis, maintenance, and treatment, according to an increasing amount of research. However, there is still some uncertainty regarding the general impact of anoikis-related genes (ARGs) on the prognostic importance, tumor microenvironment characteristics, and treatment reaction of ccRCC patients. For this study, we used The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus datasets to access the RNA sequencing results and clinical information from ccRCC patients. 29 ARGs related to survival were found using differential analysis and univariate Cox regression analysis. The samples were then divided into two clusters that had different immune traits via unsupervised cluster analysis using 29 prognosis-associated differently expressed ARGs. Then, to build an ARGs signature, 7 genes (PLAU, EDA2R, AFP, PLG, TUBB3, APOBEC3G, and MALAT1) were found using Least Absolute Shrinkage and Selection Operator regression analysis. The new ARGs signature demonstrated outstanding prognostic capability for ccRCC patients' overall survival. In conclusion, for ccRCC patients, we created an ARGs signature that strongly connects to immunological traits and therapy response. Clinicians may find this ARGs signature helpful in developing more individualized and detailed treatment strategies for ccRCC patients.
Efficacy of a Supplemental Small-Group Early Literacy Intervention Implemented by Early Childhood Educators
Authors: Goldstein Howard , Peters-Sanders Lindsey A. , Madsen Keri M. , Williams Jeffrey M. , Drobisz Jack , Broome Elizabeth A. , Freda Susan , McKeever Lauren A. , Spencer Trina D. 
Published: November 2023

Purpose:
Phonological awareness and alphabet knowledge are fundamental building blocks for literacy development. We identified preschoolers with persistent delays in these skills and evaluated the efficacy of a supplemental curriculum to remediate deficits in early literacy skills.

Method:
Using a cluster design, 21 classrooms were randomly assigned to early literacy versus language intervention conditions. Sixty children identified through fall semester assessments of phonological awareness and alphabet knowledge were enrolled in small-group instruction. Teachers completed eLearning modules, used a digital platform to enter data and facilitate data-based decision making, received practice-based coaching, and delivered 12 weekly units of an early literacy curriculum. Comparison teachers delivered similarly administered small-group language instruction.

Results:

Large effects were evident for letter sounds, phoneme segmentation, first sound, and first sound fluency measures (
d =
0.92, 4.77, 1.15, and 1.50, respectively), and nonsignificant, small effects for letter naming and blending measures (
d
= 0.26 and 0.27).

Discussion:
This early literacy intervention package had practical benefits, with 90% of experimental group preschoolers exceeding the phonemic awareness benchmark for beginning kindergarten compared to 45% in the comparison group, for example. Providing preschool teachers with tools and support for implementing a tiered approach to early literacy intervention holds promise for producing impressive gains in skills required for children to succeed in later schooling.
Recurrent ALBERT for recommendation: A hybrid architecture for accurate and lightweight restaurant recommendations
Authors: Keya Ashfia Jannat , Arpona Sayefa Arafah , Kabir Muhammad Mohsin , Mridha Muhammad Firoz 
Published: November 2023

AbstractThe online recommendation system has benefited the traditional restaurant business economically. However, finding the best restaurant during rush time and visiting new places is tough. This objective is addressed through a restaurant recommendation approach, which impacts the human decision‐making method. With the help of collaborative filtering, some user‐based recommendation systems were designed to generate the best recommendation based on user choices. Thus, a user preferences‐based method is presented using A Lite Bidirectional Encoder Representations from Transformers and Simple Recurrent Unit to suggest restaurants based on user preferences. Here, a publicly available dataset from Kaggle called Kzomato is used with 9552 samples and 21 features. And the system obtained an F1‐score, precision, and recall of 86%, which will save time and provide the best recommendation based on user preferences easily.
A survey on weakly supervised 3D point cloud semantic segmentation
Authors: Wang Jingyi , Liu Yu , Tan Hanlin , Zhang Maojun 
Published: November 2023

AbstractWith the popularity and advancement of 3D point cloud data acquisition technologies and sensors, research into 3D point clouds has made considerable strides based on deep learning. The semantic segmentation of point clouds, a crucial step in comprehending 3D scenes, has drawn much attention. The accuracy and effectiveness of fully supervised semantic segmentation tasks have greatly improved with the increase in the number of accessible datasets. However, these achievements rely on time‐consuming and expensive full labelling. In solve of these existential issues, research on weakly supervised learning has recently exploded. These methods train neural networks to tackle 3D semantic segmentation tasks with fewer point labels. In addition to providing a thorough overview of the history and current state of the art in weakly supervised semantic segmentation of 3D point clouds, a detailed description of the most widely used data acquisition sensors, a list of publicly accessible benchmark datasets, and a look ahead to potential future development directions is provided.
Aktuelles aus der Kommunikation in der Intensivmedizin
Authors: Jöbges Susanne , Meier Stefan 
Published: November 2023

Was ist neu?
Neue Entwicklungen in der Kommunikation auf der Intensivstation Eine Vielzahl an Veröffentlichungen beschäftigt sich mit dem Einsatz von virtuellen Kommunikationsmöglichkeiten für Patienten und Patientinnen, Zugehörige und das Team auf der Intensivstation (ITS). Auch auf der ITS kommen neben Handy und Tablet vermehrt Computersysteme, bis hin zum Eye-Tracking-PC, als Kommunikationshilfsmittel zum Einsatz. Das Spektrum der Anwendungsmöglichkeiten für virtuelle Kommunikationsformen ist weit. Es reicht vom Einsatz im Rahmen von Aufklärungen und der Informationsvermittlung komplexer Sachverhalte für Team, Patienten und Patientinnen oder Zugehörige, bis zum Einsatz der Telemedizin zur Verbesserung der Qualität und des interdisziplinären Austauschs auf der ITS. Ein weiteres Zukunftsthema ist die Anwendung Künstlicher Intelligenz (KI). Chatbots oder KI-gestützte Patient-Preference-Predictor-Systeme werden eingesetzt, um Inhalte zu transportieren oder Entscheidungsprozesse kommunikativ zu unterstützen.
Neue Technologien – alte Probleme? Kommunikation mit dem Team, mit Patienten und Patientinnen und deren Zugehörigen bleibt immer eine Interaktion, mit der Notwendigkeit, sich auf jemanden einzulassen und ihn wahrzunehmen. Inwieweit digitale Hilfsmittel sinnvoll für die Kommunikation im Team, mit Patienten und Patientinnen und Zugehörigen genutzt werden können, hängt somit weiterhin von der Bereitschaft ab, sich dem Anderen als Kommunikationspartner zuzuwenden.
Das Fibromyalgiesyndrom als Schmerzsyndrom in der Rheumatologie
Authors: Krasselt Marco , Baerwald Christoph 
Published: November 2023

Was ist neu?
Epidemiologie und Pathophysiologie Das Fibromyalgiesyndrom (FMS) ist bei Menschen mit rheumatologischen Erkrankungen deutlich häufiger als in der Allgemeinbevölkerung. Es kann aber auch unabhängig von anderen Erkrankungen auftreten. Es handelt sich um eine multifaktorielle Erkrankung: Physische und psychosoziale Faktoren wirken bei der Genese zusammen. Pathophysiologisch relevant scheint insbesondere eine gestörte Schmerzverarbeitung zu sein. Ob eine Small-Fiber-Neuropathie (SFN) ursächlich ist, muss weiter untersucht werden. Aktuell gibt es erstmals experimentelle Hinweise darauf, dass es sich beim FMS um eine transferierbare (Autoimmun-)Erkrankung handeln könnte.
Symptome und Diagnostik Es handelt sich beim FMS um eine klinische Diagnose: Neben generalisierten Schmerzen bestehen häufig Schlafstörungen und eine Erschöpfungsneigung – auch eine Assoziation mit einer depressiven Erkrankung kann bestehen. Bei der Diagnose und der Beurteilung des Schweregrads helfen der Widespread-Pain-Index (WPI) und der Symptome-Severity-Score (SSS).
Therapie Neben der Aufklärung über die Gutartigkeit der Erkrankung stehen nicht-medikamentöse Verfahren wie Bewegung, physikalische Therapie und kognitive Verhaltenstherapie im Vordergrund. Bei schwer zu behandelnden Verläufen kann eine multimodale Therapie indiziert sein. Analgetika, insbesondere Opioide, sollen allenfalls nachrangig und kurzfristig zum Einsatz kommen. Der Opioidantagonist Naltrexon ist ein vielversprechender Kandidat zur medikamentösen Therapie. Möglicherweise kann auch die TENS-Nutzung hilfreich sein. Im Hinblick auf den therapeutischen Einsatz von Cannabinoiden gibt es positive Beobachtungsstudien, es fehlt aber weiterhin an Evidenz aus kontrollierten Studien.
Update Lungenkarzinom – was bringt die neue Leitlinie mit sich?
Authors: Möller Miriam , Krüger Marcus , Schütte Wolfgang 
Published: November 2023

Was ist neu?
Früherkennung Risikopatienten zwischen 50 und 75 Jahren profitieren von einer jährlichen Low-Dose-CT-Untersuchung. Die Rahmenbedingungen werden aktuell erarbeitet.
Inzidenteller Lungenrundherd Ein PET-positiver, malignitätsverdächtiger Lungenrundherd mit Größenprogredienz im zeitlichen Verlauf kann ohne histopathologische Sicherung bei Inoperabilität des Patienten stereotaktisch bestrahlt werden.
Nicht kleinzelliges Lungenkarzinom (NSCLC) Es sollte bei allen Patienten mit NSCLC im Stadium IV eine Testung auf therapierbare Treiberalterationen erfolgen. Bei EGFR-Mutation (Exon 19 und 21) wird eine adjuvante Therapie mit Osimertinib über 3 Jahre empfohlen. Bei PD-L1-Expression ≥ 50% soll eine adjuvante Immuntherapie mit Atezolizumab im Anschluss an die adjuvante Chemotherapie erfolgen. Nach einer simultanen Radiochemotherapie im Stadium III soll bei PD-L1-Expression von ≥ 1% eine konsolidierende Immuntherapie mit Durvalumab über 1 Jahr erfolgen. Für viele Treiberalterationen stehen mittlerweile zielgerichtete Therapieoptionen zur Verfügung. Im Falle einer NTRK- oder RET-Fusion lautet die Empfehlung, die zielgerichtete Therapie in der Erstlinie durchzuführen. Im Falle einer MET-Exon-14-skipping-Mutation oder einer KRAS-G12C-Mutation ist eine Therapie ab der Zweitlinie sinnvoll und möglich.
Kleinzelliges Lungenkarzinom – Behandlung des Stadiums M1 (Extensive disease) Es sollte allen Patienten mit metastasiertem kleinzelligem Lungenkarzinom eine kombinierte Immunchemotherapie angeboten werden.
Grundsätze des Therapiemanagements Alle Patienten mit neu diagnostiziertem Lungenkarzinom sollten in einem interdisziplinären Tumorboard vorgestellt werden. Die in diesem Board beschlossenen Entscheidungen sollten sich an den aktuellen Leitlinien orientieren. Im Falle einer abweichenden Entscheidung muss diese gut begründet im Tumor-Konferenzprotokoll dokumentiert werden.
Long-Term Outcome of Chest Wall and Diaphragm Repair with Biological Materials
Authors: Merhej Hayan , Ali Mohammed , Nakagiri Tomoyuki , Zinne Norman , Selman Alaa , Golpon Heiko , Goecke Tobias , Zardo Patrick 
Published: November 2023

Abstract
Introduction Chest wall and/or diaphragm reconstruction aims to preserve, restore, or improve respiratory function; conserve anatomical cavities; and upkeep postural and upper extremity support. This can be achieved by utilizing a wide range of different grafts made of synthetic, biological, autologous, or bioartificial materials. We aim to review our experience with decellularized bovine pericardium as graft in the past decade.
Patients and Methods We conducted a retrospective analysis of patients who underwent surgical chest wall and/or diaphragm repair with decellularized bovine pericardium between January 1, 2012 and January 13, 2022 at our institution. All records were screened for patient characteristics, intra-/postoperative complications, chest tube and analgesic therapy duration, length of hospital stay, presence or absence of redo procedures, as well as morbidity and 30-day mortality. We then looked for correlations between implanted graft size and postoperative complications and gathered further follow-up information at least 2 months after surgery.
Results A total of 71 patients either underwent isolated chest wall (n = 51), diaphragm (n = 12), or pericardial (n = 4) resection and reconstruction or a combination thereof. No mortality was recorded within the first 30 days. Major morbidity occurred in 12 patients, comprising secondary respiratory failure requiring bronchoscopy and invasive ventilation in 8 patients and secondary infections and delayed wound healing requiring patch removal in 4 patients. There was no correlation between the extensiveness of the procedure and extubation timing (chi-squared test, p = 0.44) or onset of respiratory failure (p = 0.27).
Conclusion A previously demonstrated general viability of biological materials for various reconstructive procedures appears to be supported by our long-term results.