bluuebunny/crossref_metadata_2025_split huggingface dataset:
Packed to the Brim: Investigating the Impact of Highly Responsive Prefixes on Internet-wide Measurement Campaigns
Authors: Sattler Patrick , Zirngibl Johannes , Jonker Mattijs , Gasser Oliver , Carle Georg , Holz Ralph 
Published: November 2023

Internet-wide scans are an important tool to evaluate the deployment of services. To enable large-scale application layer scans, a fast, stateless port scan (e.g., using ZMap) is often performed ahead of time to collect responsive targets. It is a common expectation that port scans on the entire IPv4 address space provide a relatively unbiased view as they cover the complete address space. Previous work, however, has found prefixes where all addresses share particular properties. In IPv6, aliased prefixes and fully responsive prefixes, i.e., prefixes where all addresses are responsive, are a well-known phenomenon. However, there is no such in-depth analysis for prefixes with these responsiveness patterns in IPv4.
This paper delves into the underlying factors of this phenomenon in the context of IPv4 and evaluates port scans on a total of 161 ports (142 TCP & 19 UDP ports) from three different vantage points. To account for packet loss and other scanning artifacts, we propose the notion of a new category of prefixes, which we call highly responsive prefixes (HRPs). Our findings show that the share of HRPs can make up 70% of responsive addresses on selected ports. Regarding specific ports, we observe that CDNs contribute to the largest fraction of HRPs on TCP/80 and TCP/443, while TCP proxies emerge as the primary cause of HRPs on other ports. Our analysis also reveals that application layer handshakes to targets outside HRPs are, depending on the chosen service, up to three times more likely to be successful compared to handshakes with targets located in HRPs. To improve future scanning campaigns conducted by the research community, we make our study's data publicly available and provide a tool for detecting HRPs. Furthermore, we propose an approach for a more efficient, ethical, and sustainable application layer target selection. We demonstrate that our approach has the potential to reduce the number of TLS handshakes by up to 75% during an Internet-wide scan while successfully obtaining 99 % of all unique certificates.
SPADA: A Sparse Approximate Data Structure Representation for Data Plane Per-flow Monitoring
Authors: Monterubbiano Andrea , Azorin Raphael , Castellano Gabriele , Gallo Massimo , Pontarelli Salvatore , Rossi Dario 
Published: November 2023

Accurate per-flow monitoring is critical for precise network diagnosis, performance analysis, and network operation and management in general. However, the limited amount of memory available on modern programmable devices and the large number of active flows force practitioners to monitor only the most relevant flows with approximate data structures, limiting their view of network traffic. We argue that, due to the skewed nature of network traffic, such data structures are, in practice, heavily underutilized, i.e. sparse, thus wasting a significant amount of memory.
This paper proposes a Sparse Approximate Data Structure (SPADA) representation that leverages sparsity to reduce the memory footprint of per-flow monitoring systems in the data plane while preserving their original accuracy. SPADA representation can be integrated into a generic per-flow monitoring system and is suitable for several measurement use cases. We prototype SPADA in P4 for a commercial FPGA target and test our approach with a custom simulator that we make publicly available, on four real network traces over three different monitoring tasks. Our results show that SPADA achieves 2× to 11× memory footprint reduction with respect to the state-of-the-art while maintaining the same accuracy, or even improving it.
Activating Transcription Factor 5 Promotes Neuroblastoma Metastasis by Inducing Anoikis Resistance
Authors: Banerjee Debarshi , Boboila Shuobo , Okochi Shunpei , Angelastro James M. , Kadenhe-Chiweshe Angela V. , Lopez Gonzalo , Califano Andrea , Connolly Eileen P. , Greene Lloyd A. , Yamashiro Darrell J. 
Published: November 2023

Abstract

MYCN-amplified neuroblastoma often presents as a highly aggressive metastatic disease with a poor prognosis. Activating transcription factor 5 (ATF5) is implicated in neural cell differentiation and cancer cell survival. Here, we show that ATF5 is highly expressed in patients with stage 4 high-risk neuroblastoma, with increased expression correlating with a poorer prognosis. We demonstrated that ATF5 promotes the metastasis of neuroblastoma cell lines in vivo. Functionally, ATF5 depletion significantly reduced xenograft tumor growth and metastasis of neuroblastoma cells to the bone marrow and liver. Mechanistically, ATF5 endows tumor cells with resistance to anoikis, thereby increasing their survival in systemic circulation and facilitating metastasis. We identified the proapoptotic BCL-2 modifying factor (BMF) as a critical player in ATF5-regulated neuroblastoma anoikis. ATF5 suppresses BMF under suspension conditions at the transcriptional level, promoting anoikis resistance, whereas BMF knockdown significantly prevents ATF5 depletion–induced anoikis. Therapeutically, we showed that a cell-penetrating dominant-negative ATF5 peptide, CP-d/n-ATF5, inhibits neuroblastoma metastasis to the bone marrow and liver by inducing anoikis sensitivity in circulating tumor cells. Our study identified ATF5 as a metastasis promoter and CP-d/n-ATF5 as a potential antimetastatic therapeutic agent for neuroblastoma.

Significance:
This study shows that resistance to anoikis in neuroblastoma is mediated by ATF5 and offers a rationale for targeting ATF5 to treat metastatic neuroblastoma.
Physical Activity During Adolescence and Early-adulthood and Ovarian Cancer Among Women with a BRCA1 or BRCA2 Mutation
Authors: Guyonnet Emma , Kim Shana J. , Xia Yue Yin , Giannakeas Vasily , Lubinski Jan , Randall Armel Susan , Eisen Andrea , Bordeleau Louise , Eng Charis , Olopade Olufunmilayo I. , Tung Nadine , Foulkes William D. , Couch Fergus J. , Aeilts Amber M. , Narod Steven A. , Kotsopoulos Joanne 
Published: November 2023

Abstract

In the general population, physical activity has been associated with a lower risk of several cancers; however, the evidence for ovarian cancer is not clear. It is suggested that early-life physical activity may differentially impact risk. Whether this is true among women at high risk due to a pathogenic variant (mutation) in the BRCA1 or BRCA2 genes has not been evaluated. Thus, we performed a matched case–control study to evaluate the association between adolescent and early-adulthood physical activity and ovarian cancer. BRCA mutation carriers who completed a research questionnaire on various exposures and incident disease and with data available on physical activity were eligible for inclusion. Self-reported activity at ages 12–13, 14–17, 18–22, 23–29, and 30–34 was used to calculate the average metabolic equivalent of task (MET)-hours/week for moderate, vigorous, and total physical activity during adolescence (ages 12–17) and early-adulthood (ages 18–34). Conditional logistic regression was used to estimate the OR and 95% confidence intervals (CI) of invasive ovarian cancer associated with physical activity. This study included 215 matched pairs (mean age = 57.3). There was no association between total physical activity during adolescence (ORhigh vs. low = 0.91; 95% CI: 0.61–1.36; Ptrend = 0.85), early-adulthood (ORhigh vs. low = 0.78; 95% CI: 0.51–1.20; Ptrend = 0.38) and overall (ORhigh vs. low = 0.81; 95% CI: 0.54–1.23; Ptrend = 0.56) and ovarian cancer. Findings were similar for moderate (Ptrend ≥ 0.25) and vigorous (Ptrend ≥ 0.57) activity. These findings do not provide evidence for an association between early-life physical activity and BRCA-ovarian cancer; however, physical activity should continue to be encouraged to promote overall health.

Significance:
In this matched case–control study, we observed no association between physical activity during adolescence or early-adulthood and subsequent risk of ovarian cancer. These findings do not provide evidence for an association between early-life physical activity and BRCA-ovarian cancer; however, being active remains important to promote overall health and well-being.
Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy
Authors: Curran Lara , de Marvao Antonio , Inglese Paolo , McGurk Kathryn A. , Schiratti Pierre-Raphaël , Clement Adam , Zheng Sean L. , Li Surui , Pua Chee Jian , Shah Mit , Jafari Mina , Theotokis Pantazis , Buchan Rachel J. , Jurgens Sean J. , Raphael Claire E. , Baksi Arun John , Pantazis Antonis , Halliday Brian P. , Pennell Dudley J. , Bai Wenjia , Chin Calvin W.L. , Tadros Rafik , Bezzina Connie R. , Watkins Hugh , Cook Stuart A. , Prasad Sanjay K. , Ware James S. , O’Regan Declan P. 
Published: November 2023

BACKGROUND:
Hypertrophic cardiomyopathy (HCM) is an important cause of sudden cardiac death associated with heterogeneous phenotypes, but there is no systematic framework for classifying morphology or assessing associated risks. Here, we quantitatively survey genotype-phenotype associations in HCM to derive a data-driven taxonomy of disease expression.

METHODS:
We enrolled 436 patients with HCM (median age, 60 years; 28.8% women) with clinical, genetic, and imaging data. An independent cohort of 60 patients with HCM from Singapore (median age, 59 years; 11% women) and a reference population from the UK Biobank (n=16 691; mean age, 55 years; 52.5% women) were also recruited. We used machine learning to analyze the 3-dimensional structure of the left ventricle from cardiac magnetic resonance imaging and build a tree-based classification of HCM phenotypes. Genotype and mortality risk distributions were projected on the tree.

RESULTS:

Carriers of pathogenic or likely pathogenic variants for HCM had lower left ventricular mass, but greater basal septal hypertrophy, with reduced life span (mean follow-up, 9.9 years) compared with genotype negative individuals (hazard ratio, 2.66 [95% CI, 1.42–4.96];
P
<0.002). Four main phenotypic branches were identified using unsupervised learning of 3-dimensional shape: (1) nonsarcomeric hypertrophy with coexisting hypertension; (2) diffuse and basal asymmetrical hypertrophy associated with outflow tract obstruction; (3) isolated basal hypertrophy; and (4) milder nonobstructive hypertrophy enriched for familial sarcomeric HCM (odds ratio for pathogenic or likely pathogenic variants, 2.18 [95% CI, 1.93–2.28];
P
=0.0001). Polygenic risk for HCM was also associated with different patterns and degrees of disease expression. The model was generalizable to an independent cohort (trustworthiness, M
1
: 0.86–0.88).

CONCLUSIONS:
We report a data-driven taxonomy of HCM for identifying groups of patients with similar morphology while preserving a continuum of disease severity, genetic risk, and outcomes. This approach will be of value in understanding the causes and consequences of disease diversity.
Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans
Authors: Deng Kui , Gupta Deepak K. , Shu Xiao-Ou , Lipworth Loren , Zheng Wei , Thomas Victoria E. , Cai Hui , Cai Qiuyin , Wang Thomas J. , Yu Danxia 
Published: November 2023

Background:
Life’s essential 8 (LE8) is a comprehensive construct of cardiovascular health. Yet, little is known about the LE8 score, its metabolic correlates, and their predictive implications among Black Americans and low-income individuals.

Methods:
In a nested case-control study of coronary heart disease (CHD) among 299 pairs of Black and 298 pairs of White low-income Americans from the Southern Community Cohort Study, we estimated LE8 score and applied untargeted plasma metabolomics and elastic net with leave-one-out cross-validation to identify metabolite signature (MetaSig) of LE8. Associations of LE8 score and MetaSig with incident CHD were examined using conditional logistic regression. The mediation effect of MetaSig on the LE8-CHD association was also examined. The external validity of MetaSig was evaluated in another nested CHD case-control study among 299 pairs of Chinese adults.

Results:

Higher LE8 score was associated with lower CHD risk (standardized odds ratio, 0.61 [95% CI, 0.53–0.69]). The MetaSig, consisting of 133 metabolites, showed significant correlation with LE8 score (
r
=0.61) and inverse association with CHD (odds ratio, 0.57 [0.49–0.65]), robust to adjustment for LE8 score and across participants with different sociodemographic and health status ([odds ratios, 0.42–0.69]; all
P
<0.05). MetaSig mediated a large portion of the LE8-CHD association: 53% (32%–80%). Significant associations of MetaSig with LE8 score and CHD risk were found in validation cohort (
r
=0.49; odds ratio, 0.57 [0.46–0.69]).

Conclusions:
Higher LE8 score and its MetaSig were associated with lower CHD risk among low-income Black and White Americans. Metabolomics may offer an objective measure of LE8 and its metabolic phenotype relevant to CHD prevention among diverse populations.
Saint Patrick, what about legless lizards? Tracing the mitochondrial affiliation and possible origin of Anguis (Squamata: Anguidae) population in Ireland
Authors: Oskyrko Oleksandra , Parry Nicholas , Jablonski Daniel 
Published: November 2023

Abstract
Ireland is home to only one native lizards’ species, the viviparous lizard and one of the few areas of the world where there are no native snakes. However, since the end of the 19th century, there have been reports indicating the presence of legless lizards, Anguis fragilis Linnaeus, 1758 population whose origin is unknown. As this genus has been intensively studied genetically and taxonomically in the past decade, we have decided to investigate newly obtained mtDNA sequences (ND2 gene) to trace affiliation of the Anguis population in Ireland. We genetically examined 12 individuals from the Burren area (western Ireland) and compared them to available data. The Irish population was identified as belonging to A. fragilis, specifically to the most common haplotype of the Illyrian-Central European haplogroup. This genetic affiliation is shared by populations across a wide European region, including the western Balkans, Spain, France, western Hungary, Austria, Germany, Latvia, Poland, the Czech Republic, Russia, Sweden, Norway, and Great Britain. Our findings showed that the Irish population does not exhibit unique mitochondrial variability. This haplotype is present across the range of the species, including Great Britain, which is not in contrast with the earlier hypothesis that nearby populations from this area, along with human-mediated introductions, could be the source of Anguis populations in Ireland. This is thus potentially the first documented case of Anguis introduction out of the native range. However, further research, including broader sampling in Great Britain and genomics, is required to determine and trace its exact origin.
Co-Présences, Hospitalités et Mutualités
Authors: Bidima Jean G. 
Published: November 2023

Résumé
Citoyen allemand qui venait de vivre la deuxième guerre mondiale en Allemagne, Gerhard.A. Rauche émigre en Afrique du Sud dans les années 50 qui correspondent aux premières années de l’Apartheid. Spécialiste de Locke en philosophie et de Grisebach en littérature, il obtint deux doctorats dans ces disciplines. Critique de la philosophie analytique, de l’existentialisme et du Marxisme de l’Ecole de Francfort, il se pencha sur le problème la co-présence des communautés et de leurs relations. Il préconisa, en plein régime d’Apartheid et en guise de critique, la non-absolutisation des positions identitaires pour que la vie authentique et les relations communautaires soient viables. De manière oblique et subtile, il lutta contre l’Apartheid. Sa critique philosophique qui demeure prisonnière des essentialismes et du racialisme, mériterait d’être complétée par une étude minutieuse des notions d’hospitalité et de mutualité.
The International Political Theory of Dialogue of Civilisations: Philosophical Issues
Authors: Petito Fabio 
Published: November 2023

Abstract
Starting from a conception of dialogue as “fusion of horizons” inspired by Gadamerian hermeneutics this article aims to give a philosophical foundation to the argument for a dialogue of civilisations within a broad set of theoretical debates that have taken place in the fields of philosophy, political theory, and international relations. Such a discussion contributes to the international political theory of dialogue of civilisations as an argument for the construction of a multicultural peaceful international society against the background of our troubled contemporary global politics.
Nationalism, Revivalism and Pan-Islamism: Shifts in the Political and Cultural Imaginings of Allama Iqbal’s Poetry
Authors: Mishra Ravi K. 
Published: November 2023

This paper argues that contrary to some popular perceptions, the ideological shift in Iqbal dates not from 1930 (when he apparently moved towards the acceptance of the two-nation theory at the Allahabad Session of the Muslim League) but to his stay in Europe from 1905 to 1908 (after which he made a complete and abrupt shift from Indian nationalism to revivalism and Pan-Islamism). This shift is powerfully expressed in the political and cultural imaginings of both his Urdu and Persian poetry. His poetry becomes suffused with the ideas of revivalism and Pan-Islamism in counter-position to those of composite nationhood and territorial nationalism on which the Indian national movement was premised. The shift is embodied in poetic imagery and metaphor incompatible with the modern idea of nationalism, especially the dominant idea of Indian nationalism. Iqbal’s later thoughts concerning Islam’s relations with non-Muslims in India and elsewhere promote an adversarial historical and cultural narrative of Islam. Though triggered by a passionate rejection of the West and its modernity, the shift manifested not just in a critique of the West but also of all non-Islamic cultures and civilizations. Iqbal’s narrative of Islam is teleological and triumphalist. Far from being defensive about the charges of intolerance and aggression levelled against Islam by its critics, he proudly invokes imagery of the sword and the conquest in the history of Islam, while bemoaning the decline of its political power in the modern era. Iqbal’s quest is for a supposedly pure Islam of the past and its revival in the twentieth century in the form of a redefined, reconstituted and revitalized Umma which cuts across boundaries of nations, continents and ethnicities. Few poets in the history of the modern world have had such influence as Allama Iqbal, and fewer still have made such fundamental shifts.
Effectiveness of guided telerehabilitation on functional performance in community-dwelling older adults: A systematic review
Authors: Gamble CJ , van Haastregt JCM , van Dam van Isselt EF , Zwakhalen SMG , Schols JMGA 
Published: November 2023

ObjectiveTo systematically review the effectiveness of guided telerehabilitation on improving functional performance in community-dwelling older adults.Data sourcesArticles published in PubMed, Cochrane Library and Embase (Ovid) from 01 January 2010 up to 17 October 2023.Review MethodsIncluded studies had (1) a randomised controlled trial design, (2) an average population age of 65 years or older, (3) a home-based setting and (4) evaluated the effectiveness of functional performance outcome measures. The intervention was considered telerehabilitation when guided by a healthcare professional using video, audio and/or text communication technologies with a minimum frequency of once per week. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 statement guideline was followed. Methodological quality was appraised using the revised Cochrane Risk of Bias tool.ResultsA total of 26 randomised controlled trials were included. Telerehabilitation had superior ( N = 15), non-superior ( N = 16) or non-inferior ( N = 11) effectiveness for improving functional performance outcome measures compared to control interventions. No studies found the control intervention to be superior over telerehabilitation. Between study differences in intervention characteristics contributed to significant clinical heterogeneity. Five studies were found to present an overall ‘low’ risk of bias, 12 studies to present ‘some’ risk of bias and 9 studies to present an overall ‘high’ risk of bias.ConclusionThe findings suggest that telerehabilitation could be a promising alternative to in-person rehabilitation for improving functional performance in community-dwelling older adults. Additional well-designed studies with minimised bias are needed for a better understanding of effective telerehabilitation intervention strategies.
Ecology of End-of-life Medical Care for Advanced Cancer Patients in China
Authors: Yang Fei , Leng Anli , Jing Jun , Miller Mary , Wee Bee 
Published: November 2023

Aims Cancer is a leading cause of death worldwide. Approximately 30% of global cancer-related deaths occur in mainland China. However, there is a paucity of information regarding the end-of-life care-seeking behavior of patients with advanced cancer in China. Our study was to investigate end-of-life care-seeking behavior and to quantify the association between sociodemographic characteristics and the location and pattern of end-of-life care. Methods We conducted a mortality follow-back survey using caregivers’ interviews to estimate the number of individuals pre 1000 who died between 2013 and 2021 in the last 3 months of life. We collected data on hospitalization, outpatient visits, cardiopulmonary resuscitation, palliative care and hospice utilization, and place of death, stratified by age, gender, marital status, household income, residential zone, insurance type, and the primary end-of-life decision-maker of the decedents. Results We analyzed data from 857 deceased cancer patients, representing an average of 1000 individuals. Among these patients, 861 experienced at least moderate or more severe pain, 774 were hospitalized at least once, 468 received intensive treatment, 389 had at least one outpatient visit, 270 died in the hospital, 236 received cardiopulmonary resuscitation and 99 received specialist hospice care. Conclusions Our study provides insights into the end-of-life care-seeking behavior of advanced cancer patients in China and our findings serve as a useful benchmark for estimating the use of end-of-life medical care. It highlights the need for the establishment of an accessible and patient-centered palliative care and hospice system.
Modified Mucosal Reconstruction in Unilateral Complete Cleft of Lip and Primary Palate: Surgical Technique and Practical Strategies
Authors: Denadai Rafael , Lo Lun-Jou 
Published: November 2023

Background The nasal floor and intraoral lining reconstruction of unilateral complete cleft of lip and primary palate has sparsely been reported. Solution: This article combines the previously-described C-flap mucosal flap and inferior turbinate flap with the newly-described lateral nasal mucosal flap for the mucosal repair of this uncommon subtype of deformity. Valuable practical strategies are offered to optimize the surgical execution within a limited pediatric intranasal surgical access, targeting to minimize tissue trauma and bleeding.