bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accurately identifying hemagglutinin using sequence information and machine learning methods
Authors: Zou Xidan , Ren Liping , Cai Peiling , Zhang Yang , Ding Hui , Deng Kejun , Yu Xiaolong , Lin Hao , Huang Chengbing 
Published: October 2023

IntroductionHemagglutinin (HA) is responsible for facilitating viral entry and infection by promoting the fusion between the host membrane and the virus. Given its significance in the process of influenza virus infestation, HA has garnered attention as a target for influenza drug and vaccine development. Thus, accurately identifying HA is crucial for the development of targeted vaccine drugs. However, the identification of HA using in-silico methods is still lacking. This study aims to design a computational model to identify HA.MethodsIn this study, a benchmark dataset comprising 106 HA and 106 non-HA sequences were obtained from UniProt. Various sequence-based features were used to formulate samples. By perform feature optimization and inputting them four kinds of machine learning methods, we constructed an integrated classifier model using the stacking algorithm.Results and discussionThe model achieved an accuracy of 95.85% and with an area under the receiver operating characteristic (ROC) curve of 0.9863 in the 5-fold cross-validation. In the independent test, the model exhibited an accuracy of 93.18% and with an area under the ROC curve of 0.9793. The code can be found from https://github.com/Zouxidan/HA_predict.git. The proposed model has excellent prediction performance. The model will provide convenience for biochemical scholars for the study of HA.
Association between dimensions of trauma-related psychopathology and asthma in trauma-exposed women
Authors: Lin Esther R.-H. , Roeckner Alyssa R. , Fani Negar , Merrill Natalie , Gillespie Charles F. , Ely Timothy D. , Bradley Bekh , Michopoulos Vasiliki , Powers Abigail , Jovanovic Tanja , Stevens Jennifer S. 
Published: October 2023

IntroductionExposure to traumatic events and stressful life experiences are associated with a wide range of adverse mental and physical health outcomes. Studies have found post-traumatic stress disorder (PTSD), depression, and anxiety sensitivity occurrence to be common in addition to inflammatory diseases like asthma, especially in women. Moreover, overlapping neurobiological mechanisms have been linked to both PTSD and asthma.MethodsIn the current study, n = 508 women reported on presence of lifetime asthma diagnosis and symptoms of trauma-related psychopathology including PTSD and depression. A separate group of female participants (n = 64) reported on asthma, PTSD, depression and anxiety sensitivity, and underwent functional MRI scans during a fearful faces task, and their anterior insula responses were analyzed.ResultsOverall, PTSD and depression severity were significantly higher in those with asthma versus those without asthma. There was a positive association between anterior insula response to social threat cues and depression symptoms only among individuals without a lifetime presence of asthma.DiscussionThese findings provide continued evidence on the interactions between stress, neural mechanisms involved in interoception and salience detection, and trauma-related psychopathology.
Prebiotic potential of green banana flour: impact on gut microbiota modulation and microbial metabolic activity in a murine model
Authors: Baek Ga Hyeon , Kim Yu-Jeong , Lee Yukyung , Jung Suk-Chae , Seo Hwi Won , Kim Jun-Seob 
Published: October 2023

IntroductionGreen banana flour can be used as a prebiotic due to its ability to promote gut health and provide several health benefits. In this study, we investigated whether feeding mice green banana flour at different doses would alter intestinal microbiota composition.MethodsWe fed C57BL/6N mice either a Low-dose (500 mg/kg/day) or High-dose (2000 mg/kg/day) of green banana flour daily for 3 weeks, and fecal samples were collected on days 0, 14, and 21 for microbiota analysis.ResultsOur results showed that the composition of intestinal microbiota was significantly altered by day 21, regardless of the dose. Notably, the consumption of green banana flour increased the presence of beneficial bacteria, including Coriobacteriaceae_UCG-002, Turicibacter, Parasutterella, Gastranaerophilales_ge, and RF39_ge. These changes in the intestinal microorganisms were accompanied by increased biological processes such as amino acid biosynthesis and secondary metabolite biosynthesis. Conversely, the consumption of green banana flour resulted in a decrease in biological processes related to carbohydrate degradation, glycerol degradation, and similar functions.DiscussionThese results emphasize the potential of green banana flour as a prebiotic that can benefit the gut microbiome.
Cost-effectiveness of analysis serplulimab plus chemotherapy as first-line therapy for PD-L1-positive advanced esophageal squamous cell carcinoma
Authors: Zheng Hanrui , Li Jiafeng , Wen Feng , Su Na 
Published: October 2023

ObjectiveOur study aimed to evaluate the cost-effectiveness of the addition of serplulimab to chemotherapy (cisplatin and fluorouracil) for programmed death-ligand 1 (PD-L1) positive advanced esophageal squamous cell carcinoma (ESCC) as the first-line treatment in China.MethodsA three-state Markov model was established to assess the incremental cost-effectiveness ratio (ICER) for serplulimab plus chemotherapy versus chemotherapy alone. Survival data were extrapolated from the ASTRUM-007 trial, cost data were derived from local sources, and utilities were derived from published literature. Health outcomes were measured as quality-adjusted life-years (QALYs). Sensitivity and probability sensitivity analyses were used to investigate the robustness of the model.ResultsIn the base-case analysis, compared with chemotherapy alone, serplulimab gained an additional 0.16 QALYs with an incremental cost of $29,547.88, leading to an ICER of $184,674.25/QALY. Additionally, the subgroup analyses presented that the ICERs of serplulimab plus chemotherapy were $157,892.50/QALY and $127,996.45/QALY in advanced ESCC patients with 1≤ CPS&lt; 10 and CPS≥ 10, respectively. These ICERs significantly exceeded the Chinese willingness-to-pay (WTP) threshold. The deterministic sensitivity analysis illustrated that the cost of progression-free survival in serplulimab plus chemotherapy group was the parameter with the strongest influence on the ICERs.ConclusionIn the Chinese health care system, with 3 times China’s per capita gross domestic product as the WTP threshold, compared with chemotherapy alone, serplulimab combined chemotherapy is not economical for PD-L1-positive advanced ESCC in the first-line setting.
DNA oxidation after exercise: a systematic review and meta-analysis
Authors: Ye Mengxin , Dewi Luthfia , Liao Yu-Chieh , Nicholls Andrew , Huang Chih-Yang , Kuo Chia-Hua 
Published: October 2023

Purpose: 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a byproduct of DNA oxidation resulting from free radical attacks. Paradoxically, treatment with 8-OHdG accelerates tissue healing. The aim of this study is to quantify the 8-OHdG response after a single session of exercise in both trained and untrained adults.Methods: A systematic review and meta-analysis of exercise intervention studies measuring changes in blood 8-OHdG following resistance exercise and aerobic exercise were conducted. The literature search included Web of Science, PubMed, BASE, and Scopus, with publications up to February 2023 included. Subgroup analysis of training status was also conducted.Results: Sixteen studies involving 431 participants met the eligibility criteria. Resistance exercise showed a medium effect on increasing circulating 8-OHdG levels (SMD = 0.66, p &lt; 0.001), which was similar for both trained and untrained participants. However, studies on aerobic exercise presented mixed results. For trained participants, a small effect of aerobic exercise on increasing circulating 8-OHdG levels was observed (SMD = 0.42; p &lt; 0.001). In contrast, for untrained participants, a large effect of decreasing circulating 8-OHdG levels was observed, mostly after long-duration aerobic exercise (SMD = −1.16; p &lt; 0.05). Similar to resistance exercise, high-intensity aerobic exercise (5–45 min, ≥75% VO2max) significantly increased circulating 8-OHdG levels, primarily in trained participants.Conclusion: Pooled results from the studies confirm an increase in circulating 8-OHdG levels after resistance exercise. However, further studies are needed to fully confirm the circulating 8-OHdG response to aerobic exercise. Increases in 8-OHdG after high-intensity aerobic exercise are observed only in trained individuals, implicating its role in training adaptation.Systematic Review Registration: [https://Systematicreview.gov/], identifier [CRD42022324180]
Examining terror management theory in Ukraine: impact of air-raid alarms and explosions on mental health, somatic symptoms, and well-being
Authors: Stieger Stefan , Lewetz David , Paschenko Svitlana , Kurapov Anton 
Published: October 2023

ObjectiveThis study sought to evaluate Terror Management Theory (TMT) assumptions about death awareness and its psychological impact in the context of a real-world war situation with high external validity. We examined if factors such as habituation to war circumstances and psychological resilience could buffer the effects on civilians’ anxiety, physical and mental health, and affect.MethodWe implemented a pre-registered smartphone-based experience sampling method study over four weeks, with 307 participants (k = 7,824) living in war-affected areas in Ukraine whereby participants were regularly exposed to war situations, including air-raid alarms, explosions, and infrastructural problems.ResultsThe data indicated that war situations significantly increased anxiety, negatively impacting mental health, and raising somatic symptom severity. While habituation showed a mild buffering effect on these impacts, resilience did not.ConclusionThis real-world investigation supports TMT’s fundamental assumptions about death awareness and its psychological implications. However, even amidst the presence of real, life-threatening situations, the buffering effects of habituation were surprisingly minimal. This suggests that further exploration of TMT’s buffering factors in real-world scenarios is warranted.
Heart rate variability measures indicating sex differences in autonomic regulation during anxiety-like behavior in rats
Authors: Frasier Raizel M. , De Oliveira Sergio Thatiane , Starski Phillip A. , Grippo Angela J. , Hopf F. Woodward 
Published: October 2023

IntroductionMental health conditions remain a substantial and costly challenge to society, especially in women since they have nearly twice the prevalence of anxiety disorders. However, critical mechanisms underlying sex differences remain incompletely understood. Measures of cardiac function, including heart rate (HR) and HR variability (HRV), reflect balance between sympathetic (SNS) and parasympathetic (PNS) systems and are potential biomarkers for pathological states.MethodsTo better understand sex differences in anxiety-related autonomic mechanisms, we examined HR/HRV telemetry in food-restricted adult rats during novelty suppression of feeding (NSF), with conflict between food under bright light in the arena center. To assess HRV, we calculated the SDNN (reflective of both SNS and PNS contribution) and rMSSD (reflective of PNS contribution) and compared these metrics to behaviors within the anxiety task.ResultsFemales had greater HR and lower SNS indicators at baseline, as in humans. Further, females (but not males) with higher basal HR carried this state into NSF, delaying first approach to center. In contrast, males with lower SNS measures approached and spent more time in the brightly-lit center. Further, females with lower SNS indicators consumed significantly more food. In males, a high-SNS subpopulation consumed no food. Among consumers, males with greater SNS ate more food.DiscussionTogether, these are congruent with human findings suggesting women engage PNS more, and men SNS more. Our previous behavior-only work also observed female differences from males during initial movement and food intake. Thus, high basal SNS in females reduced behavior early in NSF, while subsequent reduced SNS allowed greater food intake. In males, lower SNS increased engagement with arena center, but greater SNS predicted higher consumption. Our findings show novel and likely clinically relevant sex differences in HRV-behavior relationships.
The three-factor structure of the Autism-Spectrum Quotient Japanese version in pregnant women
Authors: Zain Ekachaeryanti , Fukui Naoki , Watanabe Yuichiro , Hashijiri Koyo , Motegi Takaharu , Ogawa Maki , Egawa Jun , Nishijima Koji , Someya Toshiyuki 
Published: October 2023

BackgroundThere is a rising interest in perinatal mental health studies, and proper psychometric tools to assess autistic traits among this population in Japan are vital.ObjectiveThis study aimed to clarify the optimal factor structure of the AQ as part of a perinatal mental health research project.MethodsWe used the Japanese version of the AQ (AQ-J) to measure autistic-like traits in pregnant women. Participants were 4,287 Japanese women who were pregnant or who had given birth within the last month. We performed exploratory factor analysis (EFA) using the first sample group (n = 2,154) to obtain factor structures for the final item selections. We performed confirmatory factor analysis (CFA) using the second sample group (n = 2,133) to obtain a model with good fit, then compared the model to all previously proposed models to determine the best-fitting model.ResultsThe EFA analysis identified a model consisting of 25 items distributed across three factors. Cronbach’s alpha for the total 25-item AQ-J, 9-item “Social interaction” factor, 11-item “Non-verbal communication” factor, and 5-item “Restricted interest” factor was 0.829, 0.829, 0.755, and 0.576, respectively. McDonald’s omega and its 95% confidence interval were 0.826 (0.821–0.836), 0.835 (0.821–0.837), 0.755 (0.744–0.766), and 0.603 (0.556–0.596), respectively. CFA confirmed that the three-factor structure had an acceptable fit (goodness of fit index: 0.900, comparative fit index: 0.860, root mean square error of approximation: 0.066). These findings indicated that the three-factor model was better than the 13 existing models.ConclusionThe findings are discussed in relation to the adequacy of the AQ-J for assessing autistic traits in perinatal women. We recommend the use of this 25-item, three-factor AQ-J model for this population owing to its superiority to all previous models.
Applying machine-learning to rapidly analyze large qualitative text datasets to inform the COVID-19 pandemic response: comparing human and machine-assisted topic analysis techniques
Authors: Towler Lauren , Bondaronek Paulina , Papakonstantinou Trisevgeni , Amlôt Richard , Chadborn Tim , Ainsworth Ben , Yardley Lucy 
Published: October 2023

IntroductionMachine-assisted topic analysis (MATA) uses artificial intelligence methods to help qualitative researchers analyze large datasets. This is useful for researchers to rapidly update healthcare interventions during changing healthcare contexts, such as a pandemic. We examined the potential to support healthcare interventions by comparing MATA with “human-only” thematic analysis techniques on the same dataset (1,472 user responses from a COVID-19 behavioral intervention).MethodsIn MATA, an unsupervised topic-modeling approach identified latent topics in the text, from which researchers identified broad themes. In human-only codebook analysis, researchers developed an initial codebook based on previous research that was applied to the dataset by the team, who met regularly to discuss and refine the codes. Formal triangulation using a “convergence coding matrix” compared findings between methods, categorizing them as “agreement”, “complementary”, “dissonant”, or “silent”.ResultsHuman analysis took much longer than MATA (147.5 vs. 40 h). Both methods identified key themes about what users found helpful and unhelpful. Formal triangulation showed both sets of findings were highly similar. The formal triangulation showed high similarity between the findings. All MATA codes were classified as in agreement or complementary to the human themes. When findings differed slightly, this was due to human researcher interpretations or nuance from human-only analysis.DiscussionResults produced by MATA were similar to human-only thematic analysis, with substantial time savings. For simple analyses that do not require an in-depth or subtle understanding of the data, MATA is a useful tool that can support qualitative researchers to interpret and analyze large datasets quickly. This approach can support intervention development and implementation, such as enabling rapid optimization during public health emergencies.
Understanding the use intention and influencing factors of telerehabilitation in people with rehabilitation needs: a cross-sectional survey
Authors: Wang Mao-Yuan , Chen Hong , Gong Cheng , Peng Xu-Miao , Zhong Yan-Biao , Wu Chun-Mei , Luo Yun , Wu Yong-Qiang 
Published: October 2023

ObjectiveThis study aimed to investigate the use intention and influencing factors of telerehabilitation in people with rehabilitation needs.MethodsThis cross-sectional survey recruited a total of 183 participants with rehabilitation needs from May 2022 to December 2022. Sociodemographic and medical data were collected by a structured questionnaire. The factors influencing the use intention of telerehabilitation were measured by the extended Unified Theory of Acceptance and Use of Technology (UTAUT) model. Multiple hierarchical regression analyses were performed.ResultsA total of 150 valid questionnaires were included for analysis. The results indicated that the use intention of telerehabilitation was overall high in people with rehabilitation needs. Health condition (β = −0.21, p = 0.03), performance expectancy (β = 0.21, p = 0.01), facilitating conditions (β = 0.25, p = 0.03), perceived trust (β = 0.25, p &lt; 0.01), and self-efficacy (β = 0.19, p = 0.04) were significant factors influencing the use intention of telerehabilitation.ConclusionOverall, the use intention of telerehabilitation is high in individuals with rehabilitation needs. Health conditions, performance expectancy, facilitating conditions, perceived trust, and self-efficacy are important factors influencing the use intention of telerehabilitation in individuals with rehabilitation needs.
Neutrino Mixing Sum Rules and the Littlest Seesaw
Authors: Costa Francesco , King Stephen F. 
Published: October 2023

In this work, we study the neutrino mixing sum rules arising from discrete symmetries and the class of Littlest Seesaw (LS) neutrino models. These symmetry-based approaches all offer predictions for the cosine of the leptonic CP phase cosδ in terms of the mixing angles, θ13, θ12, θ23, while the LS models also predict the sine of the leptonic CP phase sinδ, as well as making other predictions. In particular, we study the solar neutrino mixing sum rules, arising from charged lepton corrections to tri-bimaximal (TB), bimaximal (BM), golden ratio (GR) and hexagonal (HEX) neutrino mixing, and the atmospheric neutrino mixing sum rules, arising from preserving one of the columns of these types of mixing—for example, the first or second column of the TB mixing matrix (TM1 or TM2)—and we confront them with an up-to-date global fit of the neutrino oscillation data. We show that some mixing sum rules, such as an atmospheric neutrino mixing sum rule arising from a version of neutrino golden ratio mixing (GRa1), are already excluded at 3σ, and we determine the remaining models allowed by the data. We also consider the more predictive LS models (which obey the TM1 sum rules and offer further predictions) based on constrained sequential dominance CSD(n) with n≈3. We compare for the first time the three cases n=2.5, n=3 and n=1+6≈3.45, which are favored by theoretical models, using a new type of analysis to accurately predict the observables θ12, θ23 and δ. We study all the above approaches, solar and atmospheric mixing sum rules and LS models, together so that they may be compared and to give an up-to-date analysis of the predictions of all of these possibilities, when confronted with the most recent global fits.
HUBUNGAN DUKUNGAN SOSIAL TERHADAP KUALITAS HIDUP PENDERITA DIABETES MELITUS PADA LANSIA DI RUMAH SEHAT BAZNAS JAKARTA TAHUN 2019
Authors: Purnomo Hendro , Abas Ibnu 
Published: October 2023

Menurunnya derajat kesehatan dan kemampuan fisik akan mengakibatkan lansia secara perlahan menarik diri dari hubungan dengan masyarakat sekitar, sehingga interaksi sosial menjadi menurun, dan dengan menurunnya interaksi sosial lansia, tentunya kualitas hidup yang dialami lansia juga mengalami penurunan. Tujuan penelitian ini untuk melihat hubungan dukungan sosial terhadap kualitas hidup penderita diabetes melitus pada lansia di rumah sehat baznas Jakarta. Metode Penelitian ini menggunakan deskriptif korelasi. Jumlah sampel adalah sebanyak 61 lansia penderita DM tipe 2 yang diambil dengan teknik simple random sampling. Analisis yang digunakan univariat dan bivariat melalui statistik uji chi – square dengan = 5%. Hasil Penelitian menunjukan adanya hubungan dukungan sosial terhadap kualitas hidup penderita diabetes melitus pada lansia di rumah sehat baznas jakarta tahun 2019 dengan nilai = 0,003. Simpulan terdapat hubungan dukungan sosial terhadap kualitas hidup penderita diabetes melitus pada lansia. Saran diharapkan dapat menjadi referensi untuk memberikan masukan dalam upaya untuk dapat lebih mengkoordinir dalam meningkatkan kegiatan-kegiatan sosialisasi kesehatan maupun kegiatan-kegiatan kemasyarakatan lainnya

The decline in the degree of health and physical abilities will cause the elderly to slowly withdraw from relationships with the surrounding community, so that social interaction decreases, and with decreasing social interaction of the elderly, of course the quality of life experienced by the elderly also decreases. The purpose of this study was to look at the relationship of social support to the quality of life of people with diabetes mellitus in the elderly in Rumah Sehat Baznas Jakarta. The research method uses descriptive correlation. The sample was 61 elderly with DM type 2 who were taken by simple random sampling technique. The analysis used univariate and bivariate through chi-square test statistics with = 5%. The results showed a relationship of social support for the quality of life of people with diabetes mellitus in the elderly in the healthy home of the Jakarta baznas in 2019 with a value = 0.003. Conclusion there is a relationship of social support to the quality of life of people with diabetes mellitus in the elderly. Suggestions are expected to be a reference to provide input in an effort to be more coordinated in improving health socialization activities and other social activities.