bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergizing organizational inclusion and IT competencies through resource orchestration: a longitudinal exploration
Authors: Masood Ayesha , Salameh Anas A. , Khalil Ashraf , Zhang Qingyu , Papa Armando 
Published: December 2023

PurposeThis study investigates the integration of information technology (IT) competencies with organizational inclusion initiatives and its impact on firm performance. It examines the role of organizational inclusion in promoting knowledge management capability (KMC) and the moderating effect of approach and avoidance motivation on the relationship between KMC and operational performance.Design/methodology/approachThe study is grounded in the resource orchestration theory (ROT), which conceptualizes the integration of IT competencies and organizational inclusion. It employs hierarchical regression analysis on data collected from 204 firms and 374 managerial respondents to test the proposed hypotheses.FindingsThe results indicate that IT competencies enhance the relationship between organizational inclusion and KMC. Additionally, the relationship between KMC and operational performance is weaker when employees exhibit higher levels of avoidance motivation.Practical implicationsThis study offers theoretical and managerial insights for integrating IT competencies into organizational inclusion initiatives, providing guidance for organizations seeking to enhance their performance, with a specific focus on the relevance of China as the research context.Originality/valueThis study enriches the scholarly discourse by examining the underexplored integration of IT competencies with organizational inclusion, notably in the context of China. It illuminates the moderating role of motivation in the KMC-operational performance relationship, benefiting both academia and practitioners. Furthermore, this work extends the literature by demonstrating how combining organizational inclusion and IT competencies can enhance workplace KMC, connecting it to internal knowledge resources. Theoretical implications extend beyond organizational inclusion and IT to show the broader application potential of ROT in management and information systems.
Affordability and sustainability in the human right to water
Authors: Carchi Darwin , Orellana Mercy , Martínez Andrés , Segovia Joselin 
Published: December 2023

PurposeThe purpose of this study is to analyze the affordability and sustainability of residential water consumption in Ecuador, a developing country.Design/methodology/approachTo determine affordability, the authors assess water consumption and its distribution across different income levels of the population in the three main cities: Cuenca, Guayaquil and Quito. The authors then simulate the effects of a pricing policy on sustainability by deriving demand elasticities through a quadratic almost ideal demand system (QUAIDS).FindingsResults show that Ecuador has low water tariffs with respect to other cities in Latin America, which points to its affordability. However, sustainability might not be guaranteed since consumption is overall higher than the level suggested by the World Health Organization. From an economic point of view, this could be motivated by the low tariffs. Indeed, the simulation of a pricing policy shows that higher prices can significantly reduce demand for most of the sample. However, in low-income households this reduction may compromise vital consumption.Research limitations/implicationsThis research has important implications in terms of stimulating the discussion of how water affordability and sustainability can be achieved. For the case study, Ecuador, the results indicate that sustainability may not be guaranteed and that policies need to be designed to encourage it. Another implication is that population income levels should be considered to avoid negative effects for the most vulnerable groups. The main limitations of this study are methodological. First, the QUAIDS model is based on a conditional demand model (Zhen et al., 2013), which does not take into account spending on other goods. Second, data availability is limited and prevents a deeper analysis.Originality/valueTo the best of the authors' knowledge, this is the first study to analyze these issues in Ecuador, a country that recognizes the human right to water at the constitutional level.
Evaluating the implementation of a person-centred transition programme for adolescents and young adults with long-term conditions: the role of context and organisational behaviour
Authors: Feather Julie , Kaehne Axel , Kiernan Joann 
Published: December 2023

PurposeDrawing on the experiences of healthcare professionals in one paediatric hospital, this paper explores the influence of context and organisational behaviour on the implementation of a person-centred transition programme for adolescents and young adults (AYA) with long-term conditions.Design/methodology/approachA single embedded qualitative case study design informed by a realist evaluation framework, was used. Participants who had experience of implementing the transition programme were recruited from across seven individual services within the healthcare organisation. The data were gathered through semi-structured interviews (n = 20) and analysed using thematic analysis.FindingsImplementation of the transition programme was influenced by the complex interaction of macro, meso and micro processes and contexts. Features of organisational behaviour including routines and habits, culture, organisational readiness for change and professional relationships shaped professional decision-making around programme implementation.Originality/valueThere exists a significant body of research relating to the role of context and its influence on the successful implementation of complex healthcare interventions. However, within the area of healthcare transition there is little published evidence on the role that organisational behaviour and contextual factors play in influencing transition programme implementation. This paper provides an in-depth understanding of how organisational behaviour and contextual factors affect transition programme implementation.
Developing entrepreneurship skills in scientific academia: best practices from India and Japan
Authors: Tikas Gaurav 
Published: December 2023

Purpose
This paper aims to identify such “entrepreneurial skills” that the scientific community can develop within themselves through training and practice to improve their academic research translation capabilities and performance.

Design/methodology/approach
From a qualitative perspective, this study currently presents a few findings from some of the best government-funded laboratories in India and Japan, where they are training their young researchers to be world-class scientists as well as entrepreneurs to help them commercialize their scientific research findings from lab to market for societal benefit.

Findings
This paper intends to focus on identifying some of the “best practices” in developing such capabilities that allow “entrepreneurial scientists” to take their science to the society through entrepreneurship. This paper presents two exemplary case studies about institutions that are trying to build innovation and entrepreneurship capabilities in their research groups through continuous training and practice in the fields of biotechnology (India) and autonomous transportation (Japan).

Originality/value
Policymakers and top management teams at academic institutions can learn from the “best practices” on envisioning, evaluation and execution skills for designing their innovation and entrepreneurship skill-building programs for their scientific community.
External validation of the Oakland Score to assess safe hospital discharge among adult patients with acute lower gastrointestinal bleeding in a single New Zealand Centre
Authors: Amer Mostafa , Haddow James Boyd 
Published: December 2023

AbstractBackgroundAcute lower gastrointestinal bleeding (LGIB) is a common reason for hospital admission. However, the majority resolve spontaneously and only a minority require inpatient intervention. We aimed to describe the epidemiology and aetiology of acute LGIB admissions in our institution. We also aimed to validate the Oakland Score, which can identify patients at low risk of adverse outcome from LGIB, in our population and determine the proportion who could have safely avoided admission.MethodsUsing the prospective, validated Otago Clinical Audit database (DIVA), we searched for adult patients admitted to Dunedin Hospital with a primary diagnosis of LGIB between January 2013 and December 2020. We retrieved data to calculate the Oakland Score and details of inpatient treatment from the electronic patient record. We excluded patients admitted electively, admissions related to inflammatory bowel disease, and those with upper gastrointestinal bleeding.ResultsWe identified 761 patients of which 501 met inclusion criteria (56% male, median age 76 years, 82% NZ European). Overall, 72% were managed with observation or diagnostic endoscopy, 32% received blood products, and 7% required haemostatic intervention to control bleeding. The area under the receiver operating characteristic curve for the Oakland Score was 0.85 (95% CI, 0.81–0.89). A cut‐off score of ≤10 predicted a 95% probability of safely avoiding admission. This equates to saving 30 bed‐days annually.ConclusionThe majority of patients admitted with LGIB are managed conservatively. The Oakland Score could be used as a stratification tool to safely reduce the admission rate.
Modeling of Combustor Non-Uniformities Evolution Through a High-Pressure Turbine Stage
Authors: Notaristefano Andrea , Gaetani Paolo 
Published: December 2023

Abstract
In modern gas turbines, the reduction of pollutant emissions can be achieved by employing lean-burn combustors. At the combustion chamber outlet, the flow is non-uniform and characterized by a residual swirl superimposed to steady (hot streak) and unsteady (entropy waves) temperature disturbances. During the transport from the combustor outlet to the turbine inlet, these disturbances are weakly dissipated and persist at the turbine inlet. Therefore, the interaction between the combustor non-uniformities and the turbine has to be deeply studied. To study combustor–turbine interaction experimentally, a common practice is to install combustor simulators on non-reactive turbine test facilities. For this purpose, a combustor simulator was designed and installed at the Politecnico di Milano turbine test facility. This device can generate a combined steady/unsteady temperature disturbance and swirl profile at the turbine inlet. Using this layout, several experimental campaigns have been carried out changing the type of injected disturbance, the injection position, and the turbine operating condition. In this paper, the data collected from these experiments have been used to develop simplified models to predict the transport and dissipation of combustor perturbations through a turbine's first stage. In the open literature, few attempts are discussed regarding the modeling of combustor–turbine interaction that—in authors’ opinion—represents an important tool for preliminary turbine design.
Windage Torque Reduction in Low-Pressure Turbine Cavities Part I: Concept Design and Numerical Investigations
Authors: Li Zhihui , Christodoulou Loizos , Jefferson-Loveday Richard , Ambrose Stephen , Jackson Richard , Lock Gary D. , Sangan Carl M. , Scobie James A. 
Published: December 2023

Abstract
The windage torque on rotational walls has a negative effect on the performance of the low-pressure turbine. In this paper, three novel flow control concepts (FCCs) were proposed to reduce the windage torque within a turbine stator well, with upstream and downstream cavities connected by an interstage labyrinth seal. The swirl and flow pattern inside a reference turbine cavity was first investigated and the potential locations for the FCCs were identified using numerical simulations. FCC1 was a circumferential row of leaned deflectors downstream of the labyrinth seal. FCC2 was a set of deflector vanes and platform to optimize the ingress swirl at high radius in the upstream cavity. FCC3 combined the two flow concepts and the superposition resulted in a stator well windage torque reduction of 70% when compared to the baseline design. The FCCs also showed performance benefits at off-design conditions and over a range of secondary flow rates to the cavity. In Part II, the numerical analysis and performance of the FCCs are validated in an experimental rig using additively manufactured components.
A phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the pharmacokinetics, safety, and tolerability of oral ceftibuten in healthy adult subjects
Authors: Hernández-Mitre María Patricia , Wallis Steven C. , Morgan Elizabeth E. , Dudley Michael N. , Loutit Jeffery S. , Griffith David C. , Roberts Jason A. 
Published: December 2023

ABSTRACT

This was a phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of oral ceftibuten to describe the pharmacokinetics (PK) of
cis-
ceftibuten (administered form) and
trans-
ceftibuten (metabolite), and to describe safety and tolerability at higher than licensed doses. Subjects received single 400, 600, or 800 mg doses of ceftibuten on Days 1 and 4, followed by 7 days of twice-daily dosing from Days 4 to 10. Non-compartmental methods were used to describe parent drug and metabolite PK in plasma and urine. Dose proportionality was examined using
C
max
, AUC
0–12
, and AUC
0–INF
. Accumulation was calculated as the ratio of AUC
0–12
on Days 4 and 10. Adverse events (AEs) were monitored throughout the study. Following single ascending doses, mean
cis
- and
trans-
ceftibuten
C
max
were 17.6, 24.1, and 28.1 mg/L, and 1.1, 1.5, and 2.2 mg/L, respectively;
cis
-ceftibuten urinary recovery accounted for 64.3%–86.9% of the administered dose over 48 h. Following multiple ascending doses, mean
cis
- and
trans-
ceftibuten
C
max
were 21.7, 28.1, and 38.8 mg/L, and 1.4, 1.9, and 2.8 mg/L, respectively;
cis
-ceftibuten urinary recovery accounted for 72.2%–96.4% of the administered dose at steady state. The exposure of
cis-
and
trans-
ceftibuten increased proportionally with increasing doses.
Cis
- and
trans-
ceftibuten accumulation factor was 1.14–1.19 and 1.28–1.32. The most common gastrointestinal treatment emergent AEs were mild and resolved without intervention. Ceftibuten was well tolerated. Dose proportionality and accumulation of
cis
- and
trans
-ceftibuten were observed. These results support the ongoing development of ceftibuten at doses up to 800 mg twice-daily. (The study was registered at ClinicalTrials.gov under the identifier NCT03939429.)
Development of a quadruple qRT-PCR assay for simultaneous identification of hypervirulent and carbapenem-resistant
Klebsiella pneumoniae
Authors: Xu Zhixiang , Li Baisheng , Jiang Yushan , Huang Jia , Su Lebin , Wu Weibo , Pang Qilin , Li Zhuolin , Zhang Jiaqi , Li Xiaohe , Wang Jun , Cen Fulan , Peng Ling , Liang Jinhu , Wang Fuxiang , Liu Chang , Shen Chenguang , Liu Yingxia , Yang Yang 
Published: December 2023

ABSTRACT

The increasing prevalence of hypervirulent (hv) and carbapenem-resistant (CR)
Klebsiella pneumoniae
(Kp) highlights the importance of timely and accurate differential diagnosis for epidemiological investigation and clinical management. A multiplex quantitative real-time PCR (qRT-PCR) assay for the simultaneous identification of hvKp and CR-Kp was developed and validated with excellent performance in sensitivity and specificity. Generally, the
gltA
gene for Kp, the
iucA
,
rmpA
and
rmpA2
genes for hvKp, and the
Klebsiella pneumoniae
carbapenemases (KPC) gene for CR-Kp were included in the qRT-PCR assay. The detection limits for classic Kp (cKp), CR-cKp, hvKp, and CR-hvKp strains could all reach 50 genome equivalent copies and 20 CFUs per reaction with high accuracy (
R
2
> 0.99) and reliability (CV values < 3%). Detection results from 84 Kp positive clinical samples showed 31 hvKp with 8 CR-hvKp and 53 cKp with 1 CR-cKp strains. The presence of virulence-associated factors for the identified hvKp and KPC genes for CR-Kp was confirmed by previously developed conventional PCR and antimicrobial susceptibility tests, respectively. Furthermore, the qRT-PCR identified hvKp strains showed mortality rates of ≥40% in the outbred murine infection model, while no death for the identified cKp strains. These results indicated that our multiplex qRT-PCR assay could accurately identify hvKp and CR-Kp strains, which will be of great use for the rapid and accurate diagnosis in a clinical setting and the surveillance of the circulating Kp.

IMPORTANCE

Globally, the increasing number of hypervirulent
Klebsiella pneumoniae
(hvKp) and carbapenem-resistant Kp (CR-Kp) infections poses a huge public health challenge with high morbidity and mortality. Worrisomely, due to the mobility of elements carrying virulence and drug-resistance genes, the increasing prevalence of CR-hvKp has also been found with an overwhelming mortality rate in recent years. However, the current detection methods for hvKp and CR-Kp have many disadvantages, such as long turnaround time, complex operation, low sensitivity, and specificity. Herein, a more sensitive, rapid, single-reaction, and multiplex quantitative real-time PCR was developed and validated to differentiate the circulating lineages of Kp with excellent performance in sensitivity and specificity, providing a useful tool for the differential diagnosis and the surveillance of the circulating Kp.
CoPMoV Sulfide Catalysts Supported on Natural Halloysite Nanotubes in Hydrotreating of Dibenzothiophene and Naphthalene
Authors: Vinogradov N. A. , Timoshkina V. V. , Tsilimbaeva E. A. , Zasypalov G. O. , Pimerzin A. A. , Glotov A. P. 
Published: December 2023

Abstract
Mixed sulfided CoMo catalysts supported on γ-Al2O3 and halloysite nanotubes (HNTs) were synthesized by incipient wetness impregnation with salt solutions of Keggin-type phosphorus- and vanadium-containing heteropolyacids. The synthesized materials were characterized by low-temperature nitrogen adsorption, energy dispersive X-ray fluorescence analysis, temperature-programmed reduction (both for the oxide and sulfide catalysts), and Raman spectroscopy, and were tested in hydrogenation of naphthalene and hydrodesulfurization of dibenzothiophene. The HNT-supported catalyst exhibited a greater activity in these reactions.
Aortic Coarctation Associated with Distal Aortic Arch Hypoplasia in Neonates Can Be Effectively Repaired through Left Thoracotomy
Authors: Provost Bastien , Fournier Emmanuelle , Hascoët Sebastien , Le Bret Emmanuel , Roussin Régine , Zoghbi Joy , Belli Emre 
Published: December 2023

Objectives. Aortic coarctation in neonates remains a clinical challenge. Low weight, arch hypoplasia and ductal dependence have been identified as risk factors for recurrent coarctation. We hypothesized that a tailored surgical technique may prevent recurrence. Methods. Retrospective evaluation of neonates treated for coarctation through thoracotomy was done. No primary percutaneous procedure was performed and repairs through sternotomy were excluded. Aortic hypoplasia was defined as a ratio arch diameter (mm)/patient’s weight (kg) < 1. Extended end-to-end anastomosis (EEEA), subclavian flap (Waldhausen) and Amato aortoplasty were performed. Mortality and recurrent obstruction requiring re-intervention were assessed. Results. Records of 340 consecutive patients (2003–2019) were analyzed. Preoperative median age and weight were, respectively, 10 days (1–30) and 3080 grams (1400–5180). Arch hypoplasia was documented in 31 patients (9.1%). Prostaglandin was infused in 220 (65.3%). Critical preoperative status was documented in 35 (10.8%). EEEA repair was performed in 273 (80.3%), Waldhausen was performed in 42 (12.4%), and Amato was performed in 25 (7.4%). The last two were more likely to be performed in the presence of arch hypoplasia (

p

< 0.0001). Hospital mortality occurred in 2 patients (0.6%). Thirty-six procedures (31 percutaneous/5 surgical) were performed for recurrent arch obstruction in 33 patients. Three late deaths occurred. Low-weight, hypoplastic arch, and ductal dependency did not influence the outcome. All survivors were free from residual coarctation at a mean follow-up of 3.6 ± 3.4 years postoperatively. Conclusions. Surgical repair remains the procedure of choice for neonatal coarctation. A tailored approach using alternative techniques seemed to offer comparable results even in presence of associated risk factors.
Surgical treatment of spontaneous intracranial hemorrhage in patients with cancer
Authors: Telles João Paulo Mota , Yamaki Vitor Nagai , Paiva Wellingson , Teixeira Manoel Jacobsen , Neville Iuri 
Published: December 2023

Introduction: Intracranial hemorrhage (ICH) is the most common cerebrovascular event in patients with cancer. We sought to evaluate the outcomes of surgical treatment for ICH and to determine possible pre-operative outcome predictors.
Methods: We retrospectively reviewed surgical procedures for the treatment of ICH in patients with cancer. Analyses included clinical, laboratory, and radiological characteristics. Primary endpoints were survival and mortality in index hospitalization.
Results: Ninety-four emergency neurosurgeries were performed for ICH in 88 different patients with cancer over ten years. 51 patients had chronic subdural hematomas (CSDH: 54.3%), 35 with intraparenchymal hemorrhage (37.2%), 6 with acute subdural hematoma (ASDH: 6.4%), and only 2 with epidural hemorrhages (2.1%). Median patient follow-up was 63 days (IQR=482.2). 71 patients (75.5%) died at follow-up, with a median survival of 33 days. Overall 30-day mortality was 38.3% and reached 27.5% in patients with CSDH. Lower survival was associated to higher absolute leucocyte count (HR 1.06; 95%CI 1.04-1.09), higher aPTT ratio (HR 3.02; 95% CI 1.01-9.08), higher serum CRP (HR 1.01; 95%CI 1.01-1.01), and unresponsive pupils (each unresponsive pupil - HR 2.65; 95%CI 1.50-4.68). Lower absolute platelet count was associated with a modest increase in survival rates (every 1000 platelets - HR 0.99; 95%CI 0.97-0.99).
Conclusion: Outcomes following surgical treatment of ICH in patients with cancer impose significant morbidity and mortality. Altered pupillary reflexes, coagulopathies, and increased inflammatory response were predictors of mortality for any type of ICH. CSDH was the most common type of ICH and had higher mortality rates than non-oncologic patients.
La note américaine
Authors: Leurquin Eric Claude 
Published: December 2023

1921 Les guerres indiennes sont loin. Leurs survivants ont, pour la plupart, été parqués dans des réserves où ils végètent, misérables, abandonnés à leur sort.Une exception à cette règle : le peuple osage. Il s'est vu attribuer un territoire minéral aux confins de l'Oklahoma. Or ces rochers recouvrent le plus grand gisement de pétrole des États-Unis. Les Osages sont millionnaires, roulent en voitures de luxe, envoient leurs enfants dans les plus prestigieuses universités et se font servir par des domestiques blancs. Le monde à l'envers. Un jour, deux membres de la tribu disparaissent. Un corps est retrouvé, une balle dans la tête. Puis une femme meurt empoisonnée. Et une autre. Plus tard, une maison explose. Trois morts. Qui commet ces assassinats ? Qui a intérêt à terroriser les riches Osages ? Les premières enquêtes, locales, sont bâclées, elles piétinent. C'est pourquoi, après une nouvelle série noire, ce dossier brûlant est confié au BOI (Bureau of Investigation, qui deviendra le FBI en 1935). À sa tête, un très jeune homme. Son nom est Hoover, Edgar J. Hoover. Il veut deux choses.
La première: faire toute la lumière sur cette sombre affaire, et il s'en donne les moyens, enquêteurs hors pair, méthodes rigoureuses de police scientifique, mise en fiche de la moindre information. La seconde : le pouvoir. Surtout le pouvoir. Et ce premier coup d'éclat va le lui offrir sur un plateau.