bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAKNA, RAGAM DAN EKSPRESI TARI WANKA
Authors: Purwaningsari Dewi 
Published: February 2024

Artikel penulisan ini bermaksudkan untuk menanalisi bagaimanakah makna, ragam, dan ekspresi yang terdapat dalam Tari Wanka. Tari Wanka merupakan ke dalam jenis karya tari kreasi baru dengan berpijakan non tradisi. Tari Wanka sendiri merupakan karya tari yang berkisahkan tentang kehidupan kuli tiongkok yang berada di Bangka dan bekerja sebagai penambang timah. Metode penelitian ini yaitu dengan metode penelitian kualitatif, yaitu data observasi dengan cara mengobservasi karya tari ini. Data wawancara dilakukan dengan cara wawancara virtual, yaitu wawancara melalui media telepon whatsapp, zoom muapun dengan Google Meet. Sedangkan data dokumentasi diperoleh dengan data yang telah ditemukan sebelumnya. Hasil temuannya yaitu berupa ada beberapa ragam gerak yang terdapat dalam Tari Wankadan juga ekspresi yang digunakan dengan ekspresi dingin, datar, permebrontakan/melawan, dan juga penuh kelesuan.
Human Resource Productivity: Integrating Resilience Engineering, Motivation, and Health Safety
Authors: Putra Ida Bagus Udayana , Kot Sebastian , Ibrahim Abdul Halil Hi , Rajiani Ismi 
Published: February 2024

AbstractThis study investigated the multifaceted relationship between resilience engineering practices, work motivation factors, health, safety, and environment (HSE) management to achieve employee productivity within a mining company in South Kalimantan, Indonesia. Employing structural equation modelling (SEM) on data from 178 workers, intriguing results are diverged from established research. While resilience engineering practices and work motivation factors significantly enhanced productivity, robust HSE management demonstrated a surprisingly insignificant association. This unexpected finding necessitates a closer examination of the unique context of Indonesian mining culture and HSE implementation practices. Several potential explanations emerge, including ingrained communal responsibility for safety, limited applicability of imported frameworks, prioritisation of immediate needs over long-term safety due to competitive pressures, and possible erosion of trust in bureaucratic systems. These factors highlight the need to consider cultural nuances and industry challenges when designing effective HSE interventions. Moving forward, research and practice must prioritise developing culturally sensitive HSE practices, fostering trust and employee engagement, bridging the gap between formal systems and daily realities, and gathering qualitative data to understand employee perspectives. By addressing these considerations, future interventions can effectively align HSE efforts with employee productivity, contributing to a safer, more productive, culturally relevant work environment for Indonesian miners.
Ritmo nodal: caso clínico
Authors: Álvarez Cadmilena Diana Gabriela , Merchán Coronel María Graciela , Calderon Guaraca Prissila Banesa 
Published: February 2024

Introducción. Los latidos originados en el nódulo aurículo ventricular (AV) o el haz de His, caracterizan al ritmo nodal o ritmo de la unión. Aunque poco frecuente en los adultos, se relaciona con múltiples causas. Objetivo. describir los aspectos relacionados con el diagnóstico y tratamiento de esta patología, a fin de establecer elementos novedosos e instructivos de la enfermedad. Metodología. Presentación de caso y revisión de la literatura actualizada, con énfasis en la descripción de las posibles causas relacionadas, el tratamiento y cuidados. Resultados. mujer de 30 años, con antecedentes conocidos de taquiarritmia, que acude a consulta de seguimiento. La evaluación clínica y ecocardiográfica fueron normales. Mediante la electrocardiografía se diagnosticó una taquicardia por reentrada nodal más ritmo idionodal; que fue tratada con Diltiazem. Conclusión. Para la adecuada aproximación clínica y terapéutica a estos pacientes, es posible lograr que desarrollen su vida normalmente. Para esto es indispensable una historia clínica completa. Área de estudio general: medicina. Área de estudio específica: cardiología. Tipo de estudio: Casos clínicos / Clinical cases.
Transition metal oxide nanocatalysts for the deoxygenation of palm oil to green diesel
Authors: Guerrero-Corona C. E. , Melo-Banda J. A. , Lam-Maldonado M. , Vega-Ibarra L. A. , Diaz-Zavala N. P. , Meraz-Melo M. A. 
Published: February 2024

This study investigated the hydrodeoxygenation of palm oil by different oxide nanocatalysts of transition metals α -Fe2O3, NiO, and NiFe2O4, which were synthesized by hot injection. All nanomaterials were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, and dynamic light dispersion. The catalytic evaluation was performed in a Parr-type reactor at 350°C, 3.5 MPa of H2 pressure, and 3 h of reaction. The liquid product obtained was analyzed by ultraviolet-visible light spectroscopy to identify the n-C16 generated during the reaction. The activity in the deoxygenation of fatty acids to produce n-C16 hydrocarbons has the following order: α-Fe2O3 &lt; NiFe2O4 &lt; NiO.
Association between systemic inflammation response index and chronic kidney disease: a population-based study
Authors: Li Xiaowan , Cui Lan , Xu Hongyang 
Published: February 2024

IntroductionOur objective was to explore the potential link between systemic inflammation response index (SIRI) and chronic kidney disease (CKD).MethodsThe data used in this study came from the National Health and Nutrition Examination Survey (NHANES), which gathers data between 1999 and 2020. CKD was diagnosed based on the low estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m2 or albuminuria (urinary albumin-to-creatinine ratio (ACR) of more than 30 mg/g). Using generalized additive models and weighted multivariable logistic regression, the independent relationships between SIRI and other inflammatory biomarkers (systemic immune-inflammation index (SII), monocyte/high-density lipoprotein ratio (MHR), neutrophil/high-density lipoprotein ratio (NHR), platelet/high-density lipoprotein ratio (PHR), and lymphocyte/high-density lipoprotein ratio (LHR)) with CKD, albuminuria, and low-eGFR were examined.ResultsAmong the recruited 41,089 participants, males accounted for 49.77% of the total. Low-eGFR, albuminuria, and CKD were prevalent in 8.30%, 12.16%, and 17.68% of people, respectively. SIRI and CKD were shown to be positively correlated in the study (OR = 1.24; 95% CI: 1.19, 1.30). Furthermore, a nonlinear correlation was discovered between SIRI and CKD. SIRI and CKD are both positively correlated on the two sides of the breakpoint (SIRI = 2.04). Moreover, increased SIRI levels were associated with greater prevalences of low-eGFR and albuminuria (albuminuria: OR = 1.27; 95% CI: 1.21, 1.32; low-eGFR: OR = 1.11; 95% CI: 1.05, 1.18). ROC analysis demonstrated that, compared to other inflammatory indices (SII, NHR, LHR, MHR, and PHR), SIRI exhibited superior discriminative ability and accuracy in predicting CKD, albuminuria, and low-eGFR.DiscussionWhen predicting CKD, albuminuria, and low-eGFR, SIRI may show up as a superior inflammatory biomarker when compared to other inflammatory biomarkers (SII, NHR, LHR, MHR, and PHR). American adults with elevated levels of SIRI, SII, NHR, MHR, and PHR should be attentive to the potential risks to their kidney health.
Nitric oxide-induced lipophagic defects contribute to testosterone deficiency in rats with spinal cord injury
Authors: Zhuang Yuge , Liu Wenyuan , Chen Feilong , Xie Minyu , Zhang Hanbin , Huang Zicong , Zhang Xiaoyuan , Liu Jinsheng , Ma Ke , Feng Hongrui , Ruan Shipeng , He Jing , Zhang Wansong , Zou Feng , Kang Xiangjin , Fan Yong , Zhang Guofei , Chen Zhenguo 
Published: February 2024

IntroductionMales with acute spinal cord injury (SCI) frequently exhibit testosterone deficiency and reproductive dysfunction. While such incidence rates are high in chronic patients, the underlying mechanisms remain elusive.Methods and resultsHerein, we generated a rat SCI model, which recapitulated complications in human males, including low testosterone levels and spermatogenic disorders. Proteomics analyses showed that the differentially expressed proteins were mostly enriched in lipid metabolism and steroid metabolism and biosynthesis. In SCI rats, we observed that testicular nitric oxide (NO) levels were elevated and lipid droplet-autophagosome co-localization in testicular interstitial cells was decreased. We hypothesized that NO impaired lipophagy in Leydig cells (LCs) to disrupt testosterone biosynthesis and spermatogenesis. As postulated, exogenous NO donor (S-nitroso-N-acetylpenicillamine (SNAP)) treatment markedly raised NO levels and disturbed lipophagy via the AMPK/mTOR/ULK1 pathway, and ultimately impaired testosterone production in mouse LCs. However, such alterations were not fully observed when cells were treated with an endogenous NO donor (L-arginine), suggesting that mouse LCs were devoid of an endogenous NO-production system. Alternatively, activated (M1) macrophages were predominant NO sources, as inducible NO synthase inhibition attenuated lipophagic defects and testosterone insufficiency in LCs in a macrophage-LC co-culture system. In scavenging NO (2-4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (CPTIO)) we effectively restored lipophagy and testosterone levels both in vitro and in vivo, and importantly, spermatogenesis in vivo. Autophagy activation by LYN-1604 also promoted lipid degradation and testosterone synthesis.DiscussionIn summary, we showed that NO-disrupted-lipophagy caused testosterone deficiency following SCI, and NO clearance or autophagy activation could be effective in preventing reproductive dysfunction in males with SCI.
The allocation of crop production resources in the southeast of Iran: the application of the water-energy-food nexus approach
Authors: Badih Barzin H. , Hoseini S. M. , Hashemitabar M. , Mardani Najafabadi M. 
Published: February 2024

Introduction: Due to the expansion of population, economic progress, urbanization, increasing food demands, and diversification of food systems, resources are being excessively exploited and degraded. This is compounded by the challenges posed by climate change and limited resources, as well as inadequate management practices. The concept of water-energy-food (WEF) nexus management recognizes the interdependencies among various resources, such as water, food, and energy, in order to promote sustainable resource management. By establishing a harmonious balance among different objectives, this approach aims to safeguard the well-being of both human societies and the environment, ensuring the fulfillment of needs and the preservation of benefits for both parties.Methods: In this study, the water-energy-food (WEF) nexus approach is applied to the Sistan plain, located in the southeastern region of Iran, to effectively redistribute production resources within the agricultural sector. The methodology employed is multi-objective programming, which incorporates various goals. These objectives encompass maximizing farmer revenue and energy derived from food production (measured in calories), while simultaneously minimizing greenhouse gas (GHG) emissions, irrigation water consumption, and overall energy consumption throughout the 2018–2019 crop year.Results: The findings of this study demonstrate that implementing the water-energy-food (WEF) nexus approach in the Sistan plain yields positive outcomes. Despite a reduction in the cultivation area, there is a notable shift towards growing more nutritious crops. This shift not only contributes to food security but also increases crop calorie production from 457.16 million to 565.19 million. Consequently, there is a decrease in irrigation water consumption from 261.62 million to 260.48 million cubic meters, energy consumption from 1400.13 million to 1396.81 million MJ per hectare, and greenhouse gas (GHG) emissions from 0.014 million to 0.0139 million tons per hectare.Discussion: Analyzing the physical and economic productivity reveals that GHG emissions had the highest productivity in terms of both physical and economic measures in Zahak County. As the WEF nexus approach aims to preserve and prevent environmental degradation, it is recommended to implement development and bio-balance policies utilizing this approach to ensure environmental conservation.
Differentiation of regulatory myeloid and T-cells from adult human hematopoietic stem cells after allogeneic stimulation
Authors: Mathew James M. , Sanders Jes M. , Cirocco Robert , Miller Joshua , Leventhal Joseph R. 
Published: February 2024

IntroductionDonor hematopoietic stem cell (DHSC) infusions are increasingly being studied in transplant patients for tolerance induction.MethodsTo analyze the fate of infused DHSCs in patients, we developed anin vitroculture system utilizing CD34+DHSCs stimulated with irradiated allogeneic cells in cytokine supplemented medium long-term.ResultsFlow cytometric analyses revealed loss of the CD34 marker and an increase in CD33+myeloid and CD3+T-cell proportion by 10.4% and 72.7%, respectively, after 21 days in culture. T-cells primarily expressed TcR-αβ and were of both CD4+and CD8+subsets. Approximately 80% of CD3+T cells lacked expression of the co-stimulatory receptor CD28. The CD4+compartment was predominated by CD4+CD25+CD127-FOXP3+Tregs (&gt;50% CD4+CD127- compartment) with &lt;1% of all leukocytes exhibiting a CD4+CD127+phenotype. Molecular analyses for T-cell receptor excision circles showed recent and increased numbers of TcR rearrangements in generated T cells over time suggestingde novodifferentiation from DHSCs. CD33+myeloid cells mostly expressed HLA-DR, but lacked expression of co-stimulatory receptors CD80 and CD83. When studied as modulators in primary mixed lymphocyte reactions where the cells used to stimulate the DHSC were used as responders, the DHSC-lines and their purified CD8+, CD4+, CD33+and linage negative subsets inhibited the responses in a dose-dependent and non-specific fashion. The CD8+cell-mediated inhibition was due to direct lysis of responder cells.DiscussionExtrapolation of these results into the clinical situation would suggest that DHSC infusions into transplant recipients may generate multiple subsets of donor “chimeric” cells and promote recipient Treg development that could regulate the anti-donor immune response in the periphery. These studies have also indicated that T cell maturation can occurin vitroin response to allogeneic stimulation without the pre-requisite of a thymic-like environment or NOTCH signaling stimulatory cell line.
Carbonic anhydrases in the cell wall and plasma membrane of Arabidopsis thaliana are required for optimal plant growth on low CO2
Authors: Weerasooriya Hiruni N. , Longstreth David J. , DiMario Robert J. , Rosati Viviana C. , Cassel Brittany A. , Moroney James V. 
Published: February 2024

Introduction: Plants have many genes encoding both alpha and beta type carbonic anhydrases. Arabidopsis has eight alpha type and six beta type carbonic anhydrase genes. Individual carbonic anhydrases are localized to specific compartments within the plant cell. In this study, we investigate the roles of αCA2 and βCA4.1 in the growth of the plant Arabidopsis thaliana under different CO2 regimes.Methods: Here, we identified the intracellular location of αCA2 and βCA4.1 by linking the coding region of each gene to a fluorescent tag. Tissue expression was determined by investigating GUS expression driven by the αCA2 and βCA4.1 promoters. Finally, the role of these proteins in plant growth and photosynthesis was tested in plants with T-DNA insertions in the αCA2 and βCA4 genes.Results: Fluorescently tagged proteins showed that αCA2 is localized to the cell wall and βCA4.1 to the plasma membrane in plant leaves. Both proteins were expressed in roots and shoots. Plants missing either αCA2 or βCA4 did not show any growth defects under the conditions tested in this study. However, if both αCA2 and βCA4 were disrupted, plants had a significantly smaller above- ground fresh weight and rosette area than Wild Type (WT) plants when grown at 200 μL L−1 CO2 but not at 400 and 1,000 μL L−1 CO2. Growth of the double mutant plants at 200 μL L−1 CO2 was restoredif either αCA2 or βCA4.1 was transformed back into the double mutant plants.Discussion: Both the cell wall and plasma membrane CAs, αCA2 and βCA4.1 had to be knocked down to produce an effect on Arabidopsis growth and only when grown in a CO2 concentration that was significantly below ambient. This indicates that αCA2 and βCA4.1 have overlapping functions since the growth of lines where only one of these CAs was knocked down was indistinguishable from WT growth. The growth results and cellular locations of the two CAs suggest that together, αCA2 and βCA4.1 play an important role in the delivery of CO2 and HCO3− to the plant cell.
Association of immune cell traits with Parkinson’s disease: a Mendelian randomization study
Authors: Song Zhiwei , Li Wangyu , Han Yupeng , Xu Yiya , Ding Haiqi , Wang Yinzhou 
Published: February 2024

BackgroundImmunity and neuroinflammation play crucial roles in the pathogenesis of Parkinson’s disease (PD). Nonetheless, prior investigations into the correlation between immune inflammation and PD have produced varying results. Identifying specific immune cell phenotypes that are truly associated with PD is challenging, and the causal relationship between immune cells and PD remains elusive.MethodsThis study conducted a comprehensive two-sample Mendelian randomization (MR) analysis, employing five distinct analytical approaches, to clarify the causal connection between immune cell characteristics and the risk of PD. Utilizing GWAS data, we investigated the causal relationship between 731 immune cell traits and PD. These immune cell phenotypes encompass absolute cell (AC) counts, median fluorescence intensity (MFI), and relative cell (RC) counts for B cells, cDCs, mature stage T cells, monocytes, myeloid cells, TBNK (T cells, B cells, and natural killer cells), and Tregs, as well as the logistic parameter (MP) for cDCs and TBNK.ResultsThe inverse variance weighted (IVW) analysis indicated that Myeloid DCs (p = 0.004), HVEM expression on CD45RA− CD4+ T cells (p = 0.007), CD62L− CD86+ Myeloid DCs (p = 0.015), and HLA DR expression on monocytes (p = 0.019) were associated with a reduced risk of PD. CD14+ CD16+ monocytes (p = 0.005), HLA DR+ NK cells within CD3− lymphocytes (p = 0.023), and CD28 expression on activated &amp; secreting Tregs (p = 0.032) were associated with an increased risk of PD.ConclusionThis study establishes a causal link between immune cell phenotype and the pathogenesis of PD, identifying several specific immune cell characteristics associated with PD. This could inspire researchers to delve into the pathogenesis of PD at the cellular subtype level, and aid in the identification of potential pharmacological protein targets for PD.
Perioperative immunotherapy for stage II-III non-small cell lung cancer: a meta-analysis base on randomized controlled trials
Authors: Yu Anping , Fu Feng , Li Xiongying , Wu Mengxin , Yu Meijian , Zhang Wenxiong 
Published: February 2024

BackgroundIn recent years, we have observed the pivotal role of immunotherapy in improving survival for patients with non-small cell lung cancer (NSCLC). However, the effectiveness of immunotherapy in the perioperative (neoadjuvant + adjuvant) treatment of resectable NSCLC remains uncertain. We conducted a comprehensive analysis of its antitumor efficacy and adverse effects (AEs) by pooling data from the KEYNOTE-671, NADIM II, and AEGEAN clinical trials.MethodsFor eligible studies, we searched seven databases. The randomized controlled trials (RCTs) pertaining to the comparative analysis of combination neoadjuvant platinum-based chemotherapy plus perioperative immunotherapy (PIO) versus perioperative placebo (PP) were included. Primary endpoints were overall survival (OS) and event-free survival (EFS). Secondary endpoints encompassed drug responses, AEs, and surgical outcomes.ResultsThree RCTs (KEYNOTE-671, NADIM II, and AEGEAN) were included in the final analysis. PIO group (neoadjuvant platinum-based chemotherapy plus perioperative immunotherapy) exhibited superior efficacy in OS (hazard ratio [HR]: 0.63 [0.49-0.81]), EFS (HR: 0.61 [0.52, 0.72]), objective response rate (risk ratio [RR]: 2.21 [1.91, 2.54]), pathological complete response (RR: 4.36 [3.04, 6.25]), major pathological response (RR: 2.79 [2.25, 3.46]), R0 resection rate (RR: 1.13 [1.00, 1.26]) and rate of adjuvant treatment (RR: 1.08 [1.01, 1.15]) compared with PP group (neoadjuvant platinum-based chemotherapy plus perioperative placebo). In the subgroup analysis, EFS tended to favor the PIO group in almost all subgroups. BMI (&gt;25), T stage (IV), N stage (N1-N2) and pathological response (with pathological complete response) were favorable factors in the PIO group. In the safety assessment, the PIO group exhibited higher rates of serious AEs (28.96% vs. 23.51%) and AEs leading to treatment discontinuation (12.84% vs. 5.81%). Meanwhile, although total adverse events, grade 3-5 adverse events, and fatal adverse events tended to favor the PP group, the differences were not statistically significant.ConclusionPIO appears to be superior to PP for resectable stage II-III NSCLC, demonstrating enhanced survival and pathological responses. However, its elevated adverse event (AE) rate warrants careful consideration.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier CRD42023487475.
DIAPH3 predicts survival of patients with MGMT-methylated glioblastoma
Authors: Chehade Georges , El Hajj Nady , Aittaleb Mohamed , Alkailani Maisa I. , Bejaoui Yosra , Mahdi Asma , Aldaalis Arwa A. H. , Verbiest Michael , Lelotte Julie , Ruiz-Reig Nuria , Durá Irene , Raftopoulos Christian , Tajeddine Nicolas , Tissir Fadel 
Published: February 2024

BackgroundGlioblastoma is one of the most aggressive primary brain tumors, with a poor outcome despite multimodal treatment. Methylation of the MGMT promoter, which predicts the response to temozolomide, is a well-established prognostic marker for glioblastoma. However, a difference in survival can still be detected within the MGMT methylated group, with some patients exhibiting a shorter survival than others, emphasizing the need for additional predictive factors.MethodsWe analyzed DIAPH3 expression in glioblastoma samples from the cancer genome atlas (TCGA). We also retrospectively analyzed one hundred seventeen histological glioblastomas from patients operated on at Saint-Luc University Hospital between May 2013 and August 2019. We analyzed the DIAPH3 expression, explored the relationship between mRNA levels and Patient’s survival after the surgical resection. Finally, we assessed the methylation pattern of the DIAPH3 promoter using a targeted deep bisulfite sequencing approach.ResultsWe found that 36% and 1% of the TCGA glioblastoma samples exhibit copy number alterations and mutations in DIAPH3, respectively. We scrutinized the expression of DIAPH3 at single cell level and detected an overlap with MKI67 expression in glioblastoma proliferating cells, including neural progenitor-like, oligodendrocyte progenitor-like and astrocyte-like states. We quantitatively analyzed DIAPH3 expression in our cohort and uncovered a positive correlation between DIAPH3 mRNA level and patient’s survival. The effect of DIAPH3 was prominent in MGMT-methylated glioblastoma. Finally, we report that the expression of DIAPH3 is at least partially regulated by the methylation of three CpG sites in the promoter region.ConclusionWe propose that combining the DIAPH3 expression with MGMT methylation could offer a better prediction of survival and more adapted postsurgical treatment for patients with MGMT-methylated glioblastoma.