bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cholesterol regulates insulin-induced mTORC1 signaling
Authors: Navyasree Kolaparamba V. , Ramesh Shikha T. , Umasankar Perunthottathu K. 
Published: November 2023

ABSTRACT
The rapid activation of the crucial kinase mechanistic target of rapamycin complex-1 (mTORC1) by insulin is key to cell growth in mammals, but the regulatory factors remain unclear. Here, we demonstrate that cholesterol plays a crucial role in the regulation of insulin-stimulated mTORC1 signaling. The rapid progression of insulin-induced mTORC1 signaling declines in sterol-depleted cells and restores in cholesterol-repleted cells. In insulin-stimulated cells, cholesterol promotes recruitment of mTORC1 onto lysosomes without affecting insulin-induced dissociation of the TSC complex from lysosomes, thereby enabling complete activation of mTORC1. We also show that under prolonged starvation conditions, cholesterol coordinates with autophagy to support mTORC1 reactivation on lysosomes thereby restoring insulin-responsive mTORC1 signaling. Furthermore, we identify that fibroblasts from individuals with Smith–Lemli–Opitz Syndrome (SLOS) and model HeLa-SLOS cells, which are deficient in cholesterol biosynthesis, exhibit defects in the insulin–mTORC1 growth axis. These defects are rescued by supplementation of exogenous cholesterol or by expression of constitutively active Rag GTPase, a downstream activator of mTORC1. Overall, our findings propose novel signal integration mechanisms to achieve spatial and temporal control of mTORC1-dependent growth signaling and their aberrations in disease.
iHeard STL: Development and first year findings from a local surveillance and rapid response system for addressing COVID-19 and other health misinformation
Authors: Johnson Kimberly J. , Weng Olivia , Kinzer Hannah , Olagoke Ayokunle , Golla Balaji , O’Connell Caitlin , Butler Taylor , Worku Yoseph , Kreuter Matthew W. 
Published: November 2023

Background
The U.S. Surgeon General and others have emphasized a critical need to address COVID-19 misinformation to protect public health. In St. Louis, MO, we created iHeard STL, a community-level misinformation surveillance and response system. This paper reports methods and findings from its first year of operation.

Methods
We assembled a panel of over 200 community members who answered brief, weekly mobile phone surveys to share information they heard in the last seven days. Based on their responses, we prioritized misinformation threats. Weekly surveillance data, misinformation priorities, and accurate responses to each misinformation threat were shared on a public dashboard and sent to community organizations in weekly alerts. We used logistic regression to estimate odds ratios (ORs) for associations between panel member characteristics and misinformation exposure and belief.

Results
In the first year, 214 panel members were enrolled. Weekly survey response rates were high (mean = 88.3% ± 6%). Exposure to a sample of COVID-19 misinformation items did not differ significantly by panel member age category or gender; however, African American panel members had significantly higher reported odds of exposure and belief/uncertain belief in some misinformation items (ORs from 3.4 to 17.1) compared to white panel members.

Conclusions
Our first-year experience suggests that this systematic, community-based approach to assessing and addressing misinformation is feasible, sustainable, and a promising strategy for responding to the threat of health misinformation. In addition, further studies are needed to understand whether structural factors such as medical mistrust underly the observed racial differences in exposure and belief.
Bone quality, mineral density, and fractures in heart failure
Authors: Canteri Andre Luiz , Gusmon Luana Bassan , Boguszewski Cesar Luiz , Borba Victoria Zeghbi Cochenski 
Published: November 2023

Background
The trabecular bone score (TBS) indirectly estimates bone quality and predicts low-impact fractures independently of bone mineral density (BMD). However, there is still a paucity of data linking bone and heart diseases, mainly with gaps in the TBS analysis.

Methods
In this cross-sectional study, we evaluated TBS, BMD, and fractures in patients with heart failure with reduced ejection fraction (HFrEF) and in sex-, BMI- and age-matched controls, and we assessed the fracture probability using the FRAX tool, considering active search for fractures by vertebral fracture assessment (VFA) and the adjustment for the TBS.

Results
TBS values were 1.296 ± 0.14 in 85 patients (43.5% women; age 65 ± 13 years) and 1.320 ± 0.11 in 142 controls (P = 0.07), being reduced (< 1.31) in 51.8% and 46.1% of them, respectively (P = 0.12). TBS was lower in patients than in the controls when BMD was normal (P = 0.04) and when the BMI was 15–37 kg/m2 (P = 0.03). Age (odds ratio [OR] 1.05; P = 0.026), albumin (OR 0.12; P = 0.046), statin use (OR 0.27; P = 0.03), and energy intake (OR 1.03; P = 0.014) were associated with reduced TBS. Fractures on VFA occurred in 42.4% of the patients, and VFA and TBS adjustment increased the fracture risk by 16%-23%.

Conclusion
Patients with HFrEF had poor bone quality, with a better discriminating impact of the TBS assessment when BMD was normal, and BMI was suitable for densitometric analysis. Variables related to the prognosis, severity, and treatment of HFrEF were associated with reduced TBS. VFA and TBS adjustment increased fracture risk.
Ultrasound-guided manual vacuum aspiration (USG-MVA) with cervical preparation for early pregnancy loss: A cost-effectiveness analysis
Authors: Chung Jacqueline Pui-Wah , Fekadu Ginenus , Sahota Daljit Singh , Leung Tak-Yeung , You Joyce H. S. 
Published: November 2023

Background and aim
Approximately one in four women will experience a miscarriage in their lifetime. Ultrasound-guided manual vacuum aspiration (USG-MVA) is an ideal outpatient surgical treatment alternative to traditional surgical evacuation. We aimed to examine the cost-effectiveness of US-MVA with cervical preparation for treatment of early pregnancy loss from the perspective of public healthcare provider of Hong Kong.

Methods
A decision-analytic model was designed to simulate outcomes in a hypothetical cohort of patients with early pregnancy loss on four interventions: (1) US-MVA, (2) misoprostol, (3) surgical evacuation of uterus by dilation and curettage (surgical evacuation), and (4) expectant care. Model inputs were retrieved from published literature and public data. Model outcome measures were total direct medical cost and disutility-adjusted life-year (DALY). Base-case model results were examined by sensitivity analysis.

Results
The expected DALYs (0.00141) and total direct medical cost (USD736) of US-MVA were the lowest of all interventions in base-case analysis, and US-MVA was the preferred cost-effective option. One-way sensitivity analysis showed that the misoprostol group became less costly than the US-MVA group if the evacuation rate of misoprostol (base-case value 0.832) exceeded 0.920. In probabilistic sensitivity analysis, At the willingness-to-pay (WTP) threshold of 49630 USD/DALY averted (1x gross domestic product per capita of Hong Kong), the US-MVA was cost-effective in 72.9% of the time.

Conclusions
US-MVA appeared to be cost-saving and effective for treatment of early pregnancy loss from the perspective of public healthcare provider of Hong Kong.
An eco-epidemiological model with predator switching behavior
Authors: Tripathi Deepak , Singh Anuraj 
Published: November 2023

AbstractSwitching mechanism is adopted by predator populations when they are provided with two types of prey: susceptible and infected. In this study, we propose a modification of an eco-epidemiological model with the predator switching mechanism. In the presence of switching behavior, the existence of steady states and their stability have been discussed. The qualitative changes in the proposed model have been observed by the existence of transcritical and Hopf bifurcation. Numerical simulations are performed to support our numerical findings. In the context of species’ survival when disease is present in the system, it gives some theoretical views for eco-managers to understand the dynamics.
Carbon emissions analysis of the pulp molding industry: a comparison of dry-press and wet-press production processes
Authors: Lv Zhisheng , Jiang Shaohong , Wei Lingjun , Sun Hao , Liu Yuhui , Cui Jieyu , Zhang Wanlu 
Published: November 2023

Abstract
An initial carbon emission calculation formula for the pulp molding industry was first proposed in accordance with the calculation guidelines provided by the Intergovernmental Panel on Climate Change (IPCC). The formula was primarily developed by utilizing the greenhouse gas accounting methods used in the pulp and paper industry and the life cycle assessment (LCA) theory. Carbon dioxide emissions coming into being during the production processes of dry-press and wet-press pulp molding were calculated individually, alongside the carbon emission factors throughout the lifecycle of the products. This study also delivers a comparative analysis of pulp molding products and similar cushion packaging materials. Moreover, the findings reveal that during the production phase, particularly in the formative stages of pulp molding, substantial carbon dioxide emissions would be produced, with dry-press pulp molding products exhibiting markedly higher carbon emission factors than their wet-press counterparts. The primary objective of achieving low-carbon transformation for the pulp molding industry was to reduce the carbon emissions caused by the forming process, primarily by improving the forming process and enhancing energy efficiency or utilizing clean energy.
Photocatalytic decomposition of Congo red dye by black paste@TiO2 as an efficient recyclable photocatalyst
Authors: Ghoniem Monira Galal , Ben Aissa Mohamed Ali , Adam Fatima A. , Daoush Walid M. , Khairy Mohamed 
Published: November 2023

Abstract
Manufacturing active and economical catalysts and using them in water treatment is one of the most important challenges facing researchers. Spent batteries signify a source of harmful materials when discarded without suitable treatment. In this work, a black paste as one of the main components of spent battery doped with different ratios of TiO2 nanocomposites (0, 1, 3, 7, and 10 %) were manufactured using the sol–gel method. The characterization of the paste@TiO2 nanocomposites has been investigated by SEM, XRD, DRS, FTIR, and BET analysis. The results show formation of anatase phase of TiO2 in all doped samples. While the XRD of black paste indicates the presence of Mn3O4 as a main phase. Photocatalytic properties of black paste@TiO2 nanocomposites have been investigated using Congo red dye. The results showed that the presence of TiO2 in the paste could increase the specific surface area and the composites’ photocatalytic efficiency. A higher percentage of TiO2 (10 %) added to the black paste resulted in higher black paste@TiO2 nanocomposite catalytic activity. The experimental photodegradation data were found to be consistent with the Lagergren kinetics model. The recyclability of the photocatalysts was examined for reuse in the industrial sector. Signifying that the black paste dopped with 10 % of TiO2 (PTO4) photocatalyst in this study had high reusability.
In VivoOptical Interrogation of Neuronal Responses to Genetic, Cell Type-Specific Silencing
Authors: Terzi Firat , Knabbe Johannes , Cambridge Sidney B. 
Published: November 2023

We established a low background, Cre-dependent version of the inducible Tet-On system for fast, cell type-specific transgene expressionin vivo. Coexpression of a constitutive, Cre-dependent fluorescent marker selectively allowed single-cell analyses before and after inducible, Tet-dependent transgene expression. Here, we used this method for precise, acute manipulation of neuronal activity in the living brain. The goal was to study neuronal network homeostasis at cellular resolution. Single induction of the potassium channel Kir2.1 produced cell type-specific silencing within hours that lasted for at least 3 d. Longitudinalin vivoimaging of spontaneous calcium transients and neuronal morphology demonstrated that prolonged silencing did not alter spine densities or synaptic input strength. Furthermore, selective induction of Kir2.1 in parvalbumin interneurons increased the activity of surrounding neurons in a distance-dependent manner. This high-resolution, inducible interference and interval imaging of individual cells (high I5, HighFive) method thus allows visualizing temporally precise, genetic perturbations of defined cells.SIGNIFICANCE STATEMENTGene function is studied by KO or overexpression of a specific gene followed by analyses of phenotypic changes. However, being able to predict and analyze exactly those cells in which genetic manipulation will occur is not possible. We combined two prominent transgene overexpression methods to fluorescently highlight the targeted cells appropriately before cell type-specific transgene induction. By inducing a potassium channel that decreases neuronal firing, we investigated how neuronal networks in the living mouse brain possibly compensate swift changes in cellular activities. Unlikein vitro, known compensatory homeostatic mechanisms, such as changes in synapses, were not observedin vivo. Overall, we demonstrated with our method rapid genetic manipulation and analysis of neuronal activities as well as precision transgene expression.
From “actually existing socialism” to actually existing post-socialism: János Kornai and the importance of language reform in political economy
Authors: Madlovics Bálint , Magyar Bálint 
Published: November 2023

AbstractThis paper discusses the contributions of János Kornai to the “language reform” of socialism and post-socialism, meaning the creation of new conceptual frameworks to replace the mainstream interpretation of the system with a more realistic, critical description. We show that, in the three waves of language reform under the Kádár regime – economics, sociology, and law – Kornai was a trailblazer by introducing concepts like “soft budget constraint,” “plan bargaining,” and “shortage,” which became key concepts for reform economists and dissident intellectuals in Eastern Europe. We discuss Kornai's work on post-socialism as well, particularly his paper “The System Paradigm Revisited,” and point out its merits and shortcomings in the description of the regimes of the region. Presenting our offer for a new language reform, based on Kornai, we underline the importance of proper words for understanding “actually existing post-socialism,” and the task of political economists to revise the current mainstream and analyse the phenomena of post-communist “relational economies.”
The place of dichotomous structures in the thought system of János Kornai
Authors: Mihályi Péter 
Published: November 2023

AbstractThe most significant concept of János Kornai's oeuvre is the shortage economy theory as it was presented in Anti-equilibrium more than fifty years ago. According to this, modern economies are never in equilibrium. On the markets of goods and services, the aggregate demand is either significantly higher or significantly lower than the aggregate supply. This dichotomous model is discussed in the first part of the paper.After the collapse of the communist system in 1989/90, shortages disappeared everywhere unexpectedly quickly. But it was also an unexpected development that the institutions of liberal democracy have not developed in several countries and/or collapsed after a short period. Regarding Hungary, Kornai issued an alarm signal at the turn of 2010/2011. He was the first who said that the Orbán regime had turned the country into an autocracy in barely a year. The second part of the paper examines whether Kornai's assertion, shared by many transition-economy specialist, that there are only two political systems (democracies and autocracies) is adequate for the entire range of post-socialist countries. The author's answer to this question is negative.
The connection between growth imperative of monetary production economies, the realization problem and Kornai's surplus economy
Authors: Gilányi Zsolt 
Published: November 2023

AbstractKornai challenged not only the dominant economic views of the socialist system, but also those of market economies. The former brought him fame, and the latter remained, so to speak, his scientific testament. He studied the systemic properties of different economic systems through the analytical grid of the sign of aggregate excess supply, which defined three categories: shortage economies, equilibrium economies and surplus economies. In this paper, we show that business plans postulated with the aim of realizing strictly positive net retained profits in nominal terms exclude equilibrium economies; these business plans imply a surplus economy. This definition of the business plan makes it possible to combine seemingly disparate results from different parts of the economic literature. An economy in which business plans are the rule and no economic agent can run a permanent negative budget is a surplus economy, which manifests itself in the phenomena of both growth imperative and realization problem. In short, all these phenomena are the manifestations of the same essence: the working of the business plans.
“Celestial” snapshots: Moral economic revisitations of János Kornai's the socialist system
Authors: Hajnal Zsófia 
Published: November 2023

AbstractSignificant parts of the work of the great economist and economic visionary János Kornai function as a magnifying glass in economic theory, philosophy and history. Kornai examined economic systems and system-mixes with substantial details, for then being able to focus his audiences' attention on the most relevant and critical aspects of them. One of Kornai's masterpieces, The Socialist System – a book which recently passed its 30-year publishing anniversary – is such a political economy lens on communism. I am attempting a concise conversion of this magnifying glass, to apply a Galileian metaphor, into an economic telescope. In other words, I am adding another economic lens – that of moral economics – to the Kornaian viewpoints. In a short analysis going through various dimensions of The Socialist System, I am coupling Kornai's thoughts with moral economic ideas, both from the classical and the contemporary moral economy streams. The goal with this exercise of respectfully refreshing a toolkit and style of economic analysis is to then gaze into, and partially describe a potential multitude, or spectra of economic systems, which may manifest in econodiversity.
Studies on scientific literacy in primary education: A bibliometric and content analyses
Authors: Kutlu-Abu Neşe , Bozgün Kayhan , Uluçinar-Sağir Şafak 
Published: November 2023

AbstractThis study aims to ascertain the research trends of articles on scientific literacy in primary schools. In the study, both bibliometric and content analysis techniques were employed. In the Web of Science database, 145 studies conducted between 1993 and 2021 and 60 studies conducted between 2002 and 2021 were included in the content analysis for bibliometric analysis. According to the findings, there is a rising interest in scientific literacy in primary schools. Bybee, R., and McCrae, B., were the most cited authors in this study. The United States was the most frequently cited country, and the Australian Council for Educational Research was the most frequently cited institution. Few mixed studies have been conducted on the topic of scientific literacy, as qualitative studies have dominated the field. As sample groups, primary school students and college graduates were favored. The study concluded that scientific literacy in primary school is mostly promoted by organizations, journals or authors in developed countries. The results of the study were discussed in light of the relevant literature, and suggestions for further studies were offered.
Dihydrokaempferol attenuates LPS-induced inflammation and apoptosis in WI-38 cells
Authors: Wang Qiao , Zhang Liwen , Pang Ping 
Published: November 2023

Background: Globally, pneumonia has been associated as a primary cause of mortality in children aged less than 5 years. Dihydrokaempferol (DHK) has been proposed for being correlated with the process of various diseases. Nevertheless, whether DHK has a role in the progression of infantile pneumonia remains unclear. This study aimed at exploring whether DHK was involved in the progression of infantile pneumonia.
Methods: Human fibroblast cells WI-38 were treated with lipopolysaccharide (LPS). The viability of WI-38 cells was measured via Cell counting kit-8. Reverse transcription-quantitative polymerase chain reaction was used to evaluate the levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α). Western blot analysis revealed the protein levels of IL-1β, IL-6, TNF-α, Bax, and cleaved-caspase 3. Flow cytometry was applied for exploring the apoptosis of WI-38 cells. The concentrations of IL-1β, IL-6, and TNF-α were assessed via enzyme-linked-immunosorbent serologic assay.
Results: DHK modulated the viability of WI-38 cells in infantile pneumonia. Furthermore, we identified that DHK treatment inversely changed LPS induction-mediated elevation on the levels of inflammation biomarkers. Besides, DHK counteracted LPS-induced production of reactive oxygen species (ROS) in WI-38 cells. DHK also decreased LPS-induced elevation of WI-38 cells apoptosis and mediated the levels of apoptosis-associated indexes. Moreover, modulating sirtuin-1 (SIRT1) protein level was lowered by the induction of LPS, and was reversed by DHK treatment. In addition, DHK counteracted LPS induction-mediated elevation of p-p65 and phosphorylated inhibitor of nuclear factor kappa-B kinase subunit alpha (p-IκBα) protein levels.
Conclusion: DHK alleviated LPS-induced WI-38 cells inflammation injury in infantile pneumonia through SIRT1/NF-κB pathway. The results shed light on the implications of DHK on the prevention and treatment of infantile pneumonia.
La musica per la liturgia nel nostro tempo: quale linguaggio?
Authors: Panzetti Pietro 
Published: November 2023

L’articolo descrive il progetto, sviluppato nella Cattedrale di Lodi, che ha portato alla composizione di canti d’introito per le domeniche e le feste principali dell’anno liturgico. Partendo dai principi di nobiltà e semplicità, i brani composti, sfruttando il tesoro della tradizione musicale liturgica, intendono rispondere alle esigenze liturgiche attuali.
Historicidad de los conceptos de infancia y educación en Colombia
Authors: Portilla Benavides Milton Mauricio 
Published: November 2023

El presente escrito invita al lector a conocer aspectos generales sobre la evolución del concepto de infancia y cómo esta dinámica ha fortalecido el proceso de la formación y educación de los niños y niñas en Colombia. Inicialmente, se plantea un recorrido histórico para descubrir los aspectos y las visiones de los adultos frente a los niños; seguidamente, el texto va mostrando cómo los gobiernos y las políticas, en especial en Colombia, han avanzado de tal manera que se convierten en recursos importantes, en dispositivos pedagógicos potentes que permiten pensar la educación de la Primera Infancia, desde un escenario que reconoce el valor humano, cognitivo y social de los niños y niñas como sujetos de derechos.