bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contributions of Local Land‒Atmosphere Coupling and Mesoscale Atmospheric Circulation to the 2013 Extreme Flash Drought and Heatwave Compound Event Over Southwest China
Authors: Fu Kaiqi , Wang Kaicun 
Published: November 2023

AbstractThe flash drought and heat wave compound event of the 2013 summer in Southwest China was exceptional, with profound socio‒economic impacts. Existing studies have captured the signal of this compound event; however, its causes are still poorly understood. In this study, we utilized a high‐resolution index to examine the life cycle of this compound event from 1980 to 2020 and quantified the relative contributions of land‒atmosphere coupling and mesoscale atmospheric circulation using the air parcel backward tracking method. It was found that the dry soil caused by the precipitation deficit further inhibited precipitation and caused the soil to become even drier, which then led to the development of the flash drought. The dry soil induced a substantial increase in the land‒atmosphere sensible heat flux and a rise in the near‐surface air temperature. During this process, the strength of land‒atmosphere coupling was 2.5 standard deviations higher than the mean value of the climate, playing an integral role in the near‐surface air temperature increase, accounting for 55.9% of the maximum temperature changes. The mesoscale atmospheric circulation contributed 44.1%, of which horizontal advection accounted for 41.1%, while vertical advection only accounted for 3.0%. The western Pacific subtropical high expanded westward, accompanied by the northward‐moving westerly jet stream, which prevented cold air from accessing the Southwest China, and abnormal subsidence interfered with precipitation formation. Furthermore, the control of an abnormally high‐pressure system over the region led to a decrease in cloud cover, allowing more surface incident solar radiation and contributing to the increase in the near‐surface air temperature.
What Controls the Subseasonal Precipitation Reversal Over the Western Tibetan Plateau in Winter?
Authors: Liu Yong , Li Xiangyu , Zhang Zhongshi , Li Hua , Chen Huopo , Hu Xiaoyu 
Published: November 2023

AbstractThis study reveals a significant subseasonal reversal of precipitation on the western Tibetan Plateau (WTP) from a deficit in December to an increase in January and February (JF). Changes in vertical moisture advection induced by the dynamic effects contribute mostly to the subseasonal precipitation reversal. This process involves the reversal of the subseasonal westerly driven uplift, accompanied by the weakened (enhanced) subtropical westerly jet and anticyclonic (cyclonic) anomalies over the WTP in December (JF). Further analysis shows that the North Atlantic Tripolar‐like (NAT) sea surface temperature (SST) modes could regulate the sunseasonal winter precipitation reversal over the WTP. The spatially inconsistent changes in SST can result in subseasonal reversed turbulent heat flux anomalies over Iceland‐Scandinavia in December and JF. In particular, the suppressed turbulent heat flux over the extratropical Northeast Atlantic in December leads to significant descending motion and upper tropospheric convergence. The advection of absolute vorticity induced by convergent winds associated with the NAT favors the generation of Rossby wave sources over Iceland‐Scandinavia, which then enhances the wave activity fluxes propagation. However, there are no significant changes in wave sources over Iceland‐Scandinavia in JF. The discrepancies in wave propagation intensity over Iceland‐Scandinavia determine the changes in the atmospheric pattern over the WTP, with anomalous anticyclone in December and cyclone in JF, and ultimately lead to the precipitation reversal. Furthermore, our results show that the suppressed transient eddies over the Atlantic storm track in JF may also contribute to the weakened wave propagation over Iceland‐Scandinavia.
Parallel window decoding enables scalable fault tolerant quantum computation
Authors: Skoric Luka , Browne Dan E. , Barnes Kenton M. , Gillespie Neil I. , Campbell Earl T. 
Published: November 2023

AbstractLarge-scale quantum computers have the potential to hold computational capabilities beyond conventional computers. However, the physical qubits are prone to noise which must be corrected in order to perform fault-tolerant quantum computations. Quantum Error Correction (QEC) provides the path for realizing such computations. QEC generates a continuous stream of data that decoders must process at the rate it is received, which can be as fast as 1μs per QEC round in superconducting quantum computers. If the decoder infrastructure cannot keep up, a data backlog problem is encountered and the computation runs exponentially slower. Today’s leading approaches to quantum error correction are not scalable as existing decoders typically run slower as the problem size is increased, inevitably hitting the backlog problem. Here, we show how to parallelize decoding to achieve almost arbitrary speed, removing this roadblock to scalability. Our parallelization requires some classical feed forward decisions to be delayed, slowing-down the logical clock speed. However, the slow-down is now only polynomial in the size of the QEC code, averting the exponential slowdown. We numerically demonstrate our parallel decoder for the surface code, showing no noticeable reduction in logical fidelity compared to previous decoders and demonstrating the predicted speedup.
Successful fat-only whole breast reconstruction using cultured mature adipocytes and conditioned medium containing MCP-1
Authors: Yanaga Hiroko , Koga Mika , Nishina Hiromichi , Tanaka Yoshio , Yanaga Katsu 
Published: November 2023

AbstractA mastectomy is a curative treatment for breast cancer. It causes breast and soft tissue deficits, resulting in a chest with poor vascularity. Autologous tissue breast reconstruction is commonly associated with donor site morbidity. Breast implants are another reconstruction alternative, but they are associated with infection, rupture, and the need for replacement. Autologous aspirated fat grafting has appeared as an ideal breast reconstruction method, but low graft viability and high resorption remain as the main shortcomings. We developed a novel method for fat-only grafts using cultured mature adipocytes (CMAs) mixed with their condition medium. Twenty-five mastectomy patients, aged 32–72 years, received a mixed grafting of CMAs, MCP1-containing condition medium, and fat grafts for total breast reconstruction. In follow-up periods of 24–75 months, MRI analysis showed full thickness fat-engraftment. The cell proliferation marker Ki67 was negative in post-transplant biopsy specimens from all patients. Aesthetic full breast morphology was achieved, patient satisfaction was evaluated 1 year and 3–6 years after surgery. All grafts were confirmed safe, demonstrating high reliability and long-term sustainability.
Two novel phages PSPa and APPa inhibit planktonic, sessile and persister populations of Pseudomonas aeruginosa, and mitigate its virulence in Zebrafish model
Authors: Karthika Chandrasekar , Malligarjunan Nambiraman , Jothi Ravi , Kasthuri Thirupathi , Alexpandi Rajaiah , Ravi Arumugam Veera , Pandian Shunmugiah Karutha , Gowrishankar Shanmugaraj 
Published: November 2023

AbstractThe present study explores the avenue of phage therapy as an alternative antimicrobial therapeutic approach to counter multidrug-resistant (MDR) Pseudomonas aeruginosa infection. Our study investigated two novel virulent phages PSPa and APPa, specific to P. aeruginosa, in which in vitro evaluations were carried out to assess the therapeutic potential of phages. Both the identified phages exhibited host specificity by showing antagonistic activity of about 96.43% (27/28) and 92.85% (26/28) towards the 28 MDR clinical isolates of P. aeruginosa. The PSPa phage was found to have linear dsDNA with a sequence length of 66,368 bp and 92 ORFs, of which 32 were encoded for known functions of the phage life cycle and the remaining 60 were hypothetical functions. The APPa phage was found to have linear dsDNA with 59,591 bp of genome length and 79 ORFs, of which 15 were found to have known phage functions and the remaining 64 were found to be hypothetical proteins. Notably, the genome of both the phages lacks genes coding for tRNA, rRNA, and tmRNA. The phylogenetic analysis revealed that PSPa and APPa share > 95% sequence similarity with previously sequenced Pseudomonas viruses of their respective families. Further, the in vivo efficacy evaluation using the zebrafish model revealed that the treatment with PSPa and APPa has remarkably improved the survival rate of bacterial-infected zebrafish, reinforcing the anti-infective potential of the isolated phages PSPa and APPa against P. aeruginosa infection.
Exploring the impact of integrated polyvagal exercises and knee reinforcement in females with grade II knee osteoarthritis: a randomized controlled trial
Authors: Rizvi Moattar Raza , Sharma Ankita , Hasan Shahnaz , Ahmad Fuzail , Asad Mohammad Rehan , Iqbal Amir , Alghadir Ahmad H. 
Published: November 2023

AbstractThis study aimed to compare the effects of knee strengthening exercises to those of polyvagal theory–based exercises combined with knee strengthening exercises on selected outcomes in women with grade II knee osteoarthritis (OA). A randomized controlled trial was conducted, in which 60 female participants diagnosed with grade II knee OA, with a mean age of 57.27 ± 7.81 years and knee pain rated between 4 and 7 on the visual analog scale (VAS), were assigned to either the knee strengthening exercise group (Group 1, n = 30) or the polyvagal theory–based exercise plus knee strengthening exercise group (Group 2, n = 30). Pre- and posttreatment assessment of outcome variables, including WOMAC scores (joint pain, joint stiffness, functional limitations, and the overall index), WHOQOL scores (overall quality of life, general health, physical, psychological, social, and environmental domains), and heart rate variability (HRV, time and frequency domains), were analyzed. Group 2 demonstrated significantly greater reductions in joint pain, stiffness, and functional limitations than Group 1 after the intervention. Group 2 presented with significantly improved WOMAC scores, indicating better overall outcomes. Group 2 showed significant improvements in the psychological and social domains regarding quality of life. There were no significant differences in the physical domain or the environmental domain. Group 2 showed a significant increase in high-frequency power (HF) and a significant decrease in the LF/HF ratio, suggesting improved autonomic regulation. A combination of polyvagal exercise and knee strengthening training resulted in superior outcomes compared to knee strengthening exercises alone in women with grade II knee OA. These findings support the potential effectiveness of incorporating polyvagal exercises as an adjunctive intervention for osteoarthritis management.
Comparisons of conventional in vitro fertilization versus intracytoplasmic sperm injection in women with thyroid autoimmunity and non-male factor infertility, a propensity score matching analysis
Authors: Zhang Yuchao , Liu Yanli , Shen Chunyan , Guan Yichun 
Published: November 2023

AbstractThe aim of the study is to compare the outcomes between the insemination methods of conventional in vitro fertilization and intracytoplasmic sperm injection in infertile women with thyroid autoimmunity and non-male factor infertility. This was a retrospective cohort study which included women with thyroid autoimmunity and non-male factor infertility. Reproductive outcomes such as embryo development parameters and clinical outcomes were compared between the two groups. The propensity score matching was applied to balance the general characteristics with significant differences between the two groups. Generalized estimating equations were used to explore the impact of ICSI on the embryo development potential of the inseminated oocytes. Sensitivity analysis using E-values was used to account for unknown confounders. After 1:2 propensity score matching, the general characteristics were all comparable. The good cleavage embryo rate, blastocyst utilization rate, and good blastocyst rate were significantly lower in the intracytoplasmic sperm injection group than those in the conventional in vitro fertilization group. After controlling for the confounding factors, intracytoplasmic sperm injection was significantly negatively associated with development of usable blastocysts and good blastocysts, while showed no impact on fertilized oocytes, usable cleavage embryos and good cleavage embryos. Although limited by the limited sample size, there were comparable clinical and obstetrical outcomes between conventional in vitro fertilization and intracytoplasmic sperm injection groups. Intracytoplasmic sperm injection neither improved the embryo development potential nor increased the clinical pregnancy and live birth rates compared to conventional in vitro fertilization in the studied population. Prospective studies that randomly divide the studied population in two the two groups and compare the reproductive outcomes are warranted.
Photocatalytic degradation of tetracycline antibiotics by RGO-CdTe composite with enhanced apparent quantum efficiency
Authors: Ghosh Suvendu , Chakraborty Koushik , Pal Tanusri , Ghosh Surajit 
Published: November 2023

AbstractRGO-CdTe composite was synthesized using a straightforward, easy-to-realize, one-pot solvothermal technique. The synthesized composite was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Brunauer-Emmett-Teller method (BET), Raman spectra, UV-Vis absorption, and photoluminescence measurement. The RGO-CdTe composite exhibited 83.6% photocatalytic degradation efficiency for the aqueous tetracycline (TC) antibiotic solution and the apparent quantum yield (AQY) for the same was as high as 22.29% which is 2.63 times higher than that of CdTe. The scavenger investigation demonstrated that although hole acts as the leading active species, despite that, superoxide and hydroxyl radicals have also played crucial roles. The initial pH-dependent photocatalytic performance was measured. The zeta potential of the composite at different pH values was evaluated to establish the photocatalytic performance of the RGO-CdTe towards TC degradation at different pH. The recycling experiment depicts that only a 10% degradation performance declines after 5 times recycle use of the RGO-CdTe photocatalyst. An efficient photocurrent generation in RGO-CdTe thin film device has also been observed. Our study establishes as-synthesized composite of RGO-CdTe as a highly potential, and stable photocatalyst for the degradation of antibiotics from the polluted aqueous environment with a very good photoinduced charge generation efficiency in its solid phase.
CSA@g-C3N4 as a novel, robust and efficient catalyst with excellent performance for the synthesis of 4H-chromenes derivatives
Authors: Hosseini Saber , Azizi Najmedin 
Published: November 2023

AbstractA pioneering robust and green heterogeneous acidic catalyst (CSA@g-C3N4) was rationally designed via immobilization of camphorsulfonic acid (CSA) on the g-C3N4 surface under mild conditions. Grafting CSA in the g-C3N4 lattice is distinguished as the root cause of facilitating the structure change of g-C3N4, leading to a unique morphology, accordingly the remarkable catalytic efficiency of CSA@g-C3N4. The morphology of new as-prepared nano-catalyst was specified by means of FT-IR, XRD, SEM, EDS, TEM, TGA, and BET. For the first time, it is exhibited that the efficient catalyst CSA@g-C3N4 can productively accomplish the three-component reactions with high yields and also serve as an inspiration for easily performing various sorts of MCRs based on our finding. The recommended synthesis pathway of chromenes derivatives is facile and cost-effective which applies a condensation reaction of salicylaldehyde, thiophenol, and malononitrile followed by ready purification in a benign manner. Moreover, the CSA@g-C3N4 nanocomposite can be promptly reused, illustrating no sensational decrease in the catalytic activity after ten times.
Green synthesis of biocompatible Fe3O4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic-hyperthermia applications
Authors: Eldeeb Bahig A. , El-Raheem Walaa M. Abd , Elbeltagi Shehab 
Published: November 2023

AbstractGreen synthesis of nanoparticles (NPs) is eco-friendly, biocompatible, cost-effective, and highly stable. In the present study, Citrus sinensis peel extract was utilized to the fabrication of superparamagnetic iron oxide nanoparticles (SPIONs). The fabricated SPIONs were first characterized using UV–Visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). The UV–Vis spectra analysis displayed a peak at 259 nm due to the surface plasmon resonance. The FTIR spectrum showed bands at 3306 cm−1, and 1616 cm−1 revealed the protein’s involvement in the development and capping of NPs. TEM analysis indicated that green synthesized SPIONs were spherical in shape with particle size of 20–24 nm. Magnetization measurements indicate that the synthesized SPIONs exhibited superparamagnetic behavior at room temperature. The antimicrobial activity, minimum inhibitory concentration (MIC), antioxidant potential, anti-inflammatory effect, and catalytic degradation of methylene blue by SPIONs were investigated in this study. Results demonstrated that SPIONs had variable antimicrobial effect against different pathogenic multi-drug resistant bacteria. At the highest concentration (400 μg/mL), SPIONs showed inhibition zones (14.7–37.3 mm) against all the target isolates. Furthermore, the MIC of synthesized SPIONs against Staphylococcus aureus, Streptococcus mutans, Bacillus subtilis, Escherichia coli, Klebsiella pneumonia, and Candida albicans were 3, 6.5, 6.5, 12.5, 50, 25 μg/mL, respectively. SPIONs exhibited strong antioxidant, anti-inflammatory, and catalytic dye degradation activities. Interestingly, Fe3O4 SPIONs shows optimum magnetic hyperthermia (MHT) techniques under an alternating magnetic field (AMF) measured in specific absorption rate (SAR) of 164, 230, and 286 W/g at concentrations 1, 5, and 10 mg/mL, respectively. Additionally, these newly fabricated SPIONs virtually achieve significant execution under the AMF in fluid MHT and are suitable for biomedical applications.
Asthma incidence can be influenced by climate change in Italy: findings from the GEIRD study—a climatological and epidemiological assessment
Authors: Bonomo S. , Marchetti P. , Fasola S. , Vesentini R. , Marcon A. , Ferrante G. , Antonicelli L. , Battaglia S. , Bono R. , Squillacioti G. , Murgia N. , Pirina P. , Villani S. , La Grutta S. , Verlato G. , Viegi G. 
Published: November 2023

AbstractAn association between climatic conditions and asthma incidence has been widely assumed. However, it is unclear whether climatic variations have a fingerprint on asthma dynamics over long time intervals. The aim of this study is to detect a possible correlation of the Summer North Atlantic Oscillation (S-NAO) index and the self-calibrated palmer drought severity index (scPDSI) with asthma incidence over the period from 1957 to 2006 in Italy. To this aim, an analysis of non-stationary and non-linear signals was performed on the time series of the Italian databases on respiratory health (ISAYA and GEIRD) including 36,255 individuals overall, S-NAO, and scPDSI indices to search for characteristic periodicities. The ISAYA (Italian Study on Asthma in Young Adults) and GEIRD (Gene Environment Interactions in Respiratory Diseases) studies collected information on respiratory health in general population samples, born between 1925 and 1989 and aged 20–84 years at the time of the interview, from 13 Italian centres. We found that annual asthma total incidence shared the same periodicity throughout the 1957–2006 time interval. Asthma incidence turned out to be correlated with the dynamics of the scPDSI, modulated by the S-NAO, sharing the same averaged 6 year-periodicity. Since climate patterns appear to influence asthma incidence, future studies aimed at elucidating the complex relationships between climate and asthma incidence are warranted.
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway
Authors: Tian Wang Ze , Yue Qi , Fei Wang , Yao Peng Zi , Han Rui Qin , Tang Jianguo 
Published: November 2023

Abstract
Sepsis is known to cause damage to the intestinal mucosa, leading to bacterial translocation, and exacerbation of both local and remote organ impairments. In the present study, fecal samples were collected from both septic and healthy individuals. Analysis through 16s rRNA sequencing of the fecal microbiota revealed that sepsis disrupts the balance of the gut microbial community. Recent research has highlighted the association of lipid metabolism with disease. By analyzing the fecal metabolome, four lipid metabolites that showed significant differences between the two groups were identified: PE (O-16:0/0:0), PE (17:0/0:0), PE (0:0/14:0), and PE (12:0/20:5 (5Z, 8Z, 11Z, 14Z, 17Z)). Notably, the serum levels of PE (0:0/14:0) were higher in the healthy group. Subsequent in vitro and in vivo experiments demonstrated the protective effects of this compound against sepsis-induced intestinal barrier damage. Label-free proteomic analysis showed significant differences in the expression levels of the aryl hydrocarbon receptor (AHR), a protein implicated in sepsis pathogenesis, between the LPS-Caco-2 and LPS-Caco-2 + PE (0:0/14:0) groups. Further analysis, with the help of Discovery Studio 3.5 software and co-immunoprecipitation assays, confirmed the direct interaction between AHR and PE (0:0/14:0). In the cecal ligation and puncture (CLP) model, treatment with PE (0:0 /14:0) was found to up-regulate the expression of tight junction proteins through the AHR/Cytochrome P450, family 1, subfamily A, and polypeptide 1 (CYP1A1) pathway. This highlights the potential therapeutic use of PE (0:0/14:0) in addressing sepsis-induced intestinal barrier damage.