bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geological insights from the newly discovered granite of Sif Island between Thwaites and Pine Island glaciers
Authors: Marschalek James W. , Thomson Stuart N. , Hillenbrand Claus-Dieter , Vermeesch Pieter , Siddoway Christine , Carter Andrew , Nichols Keir , Rood Dylan H. , Venturelli Ryan A. , Hammond Samantha J. , Wellner Julia , van de Flierdt Tina 
Published: February 2024

AbstractLarge-scale geological structures have controlled the long-term development of the bed and thus the flow of the West Antarctic Ice Sheet (WAIS). However, complete ice cover has obscured the age and exact positions of faults and geological boundaries beneath Thwaites Glacier and Pine Island Glacier, two major WAIS outlets in the Amundsen Sea sector. Here, we characterize the only rock outcrop between these two glaciers, which was exposed by the retreat of slow-flowing coastal ice in the early 2010s to form the new Sif Island. The island comprises granite, zircon U-Pb dated to ~177–174 Ma and characterized by initial ɛNd, 87Sr/86Sr and ɛHf isotope compositions of -2.3, 0.7061 and -1.3, respectively. These characteristics resemble Thurston Island/Antarctic Peninsula crustal block rocks, strongly suggesting that the Sif Island granite belongs to this province and placing the crustal block's boundary with the Marie Byrd Land province under Thwaites Glacier or its eastern shear margin. Low-temperature thermochronological data reveal that the granite underwent rapid cooling following emplacement, rapidly cooled again at ~100–90 Ma and then remained close to the Earth's surface until present. These data help date vertical displacement across the major tectonic structure beneath Pine Island Glacier to the Late Cretaceous.
The onset of mental health disparities in sexual minority and majority youth: evidence from the UK Millennium Cohort Study
Authors: Booth Charlotte , Fitzsimons Emla 
Published: February 2024

AbstractDecades of research shows that sexual minority youth (SMY) display heightened risk for mental health problems, although the onset of such disparities remains unclear. The Millennium Cohort Study is the largest nationally representative longitudinal study of adolescents in the United Kingdom. In this study, participants (N = 10,047, 50% female) self-reported their sexual identity at age 17 and had parent-reported mental health data, from the Strengths and Difficulties Questionnaire, reported across five waves at ages 5, 7, 11, 14, and 17. Multilevel linear spline models, stratified by sex, were used to examine mental health trajectories between sexual identity groups (completely heterosexual, mostly heterosexual, SMY). SMY showed heightened peer problems from the baseline assessment at age five, increasing over time, and heightened emotional problems from age 11, increasing over time. Mostly heterosexual youth showed heightened emotional problems at age 11 in males, and at age 17 in females. Findings are discussed in light of the literature on minority stress and gender conformity in youth. The use of parent-reported mental health data means that estimates are likely to be conservative. We conclude that interventions supporting SMY should start early and be available throughout adolescence.
Geochemical and Isotopic (Nd, Sr) Tracing of the Origin of REE Enrichment in the Cambrian Georgina Basin Phosphorites
Authors: Zivak Diana , Spandler Carl , Valetich Matthew 
Published: February 2024

AbstractPhosphorites of the Georgina Basin (northern Australia) are an established economic source of phosphate and have recently been recognized to be a potential source of rare earth elements (REE). Previous bulk‐rock geochemistry work focused on the eastern margin of the basin revealed that phosphorites from the southern region have significantly higher (up to 0.5%) REE contents than equivalent prospects further to the north. In this study, we examine the origin of REE enrichment in the Georgina Basin phosphorites using an integrated geochemical, petrographic, mineralogical, and isotopic (Sm‐Nd and Sr) approach. The trace element geochemistry of primary phosphate minerals is consistent with a seawater origin for the REEs in phosphorites, with minimal input from the underlying basement rocks. Variations in total REE concentrations are controlled largely by the seawater composition, depositional environment, and the texture of the phosphorite (grainstone vs. mudstone phosphorite). Grainstone phosphorite yields on average higher concentrations of REEs compared to the mudstone phosphorite, likely due to the higher surface‐to‐mass ratio of the grainstone phosphorite resulting in the uptake of higher concentrations of REEs during coastal reworking. The formation of the low‐REE northern and central deposits took place during early transgression in oxidized, shallow supratidal to subtidal platformal environments. During the subsequent main transgressive event, fault‐controlled topography in the southern domain allowed phosphogenesis along basement highs to be facilitated along a redox boundary, where more saline and REE‐rich deep anoxic bottom waters, along with Fe‐cycling and bacterial mediation played a major role in the enrichment of REEs in the southern phosphorites.
Hydrodynamically‐Driven Deposition of Mud in River Systems
Authors: Dunne K. B. J. , Nittrouer J. A. , Abolfazli E. , Osborn R. , Strom K. B. 
Published: February 2024

AbstractThe riverine transport and deposition of mud is the primary agent of landscape construction and evolution in many fluvial and coastal environments. Previous efforts exploring this process have raised uncertainty regarding the effects of hydrodynamic and chemical controls on the transport and deposition of mud, and thus the constructions of muddy coastal and upstream environments. As such, direct measurements are necessary to constrain the deposition of mud by river systems. Here, we combine laboratory evidence and a field investigation in the Mississippi River delta to explore the controls on the riverine transport and deposition of mud. We show that the flocculation of mud, with floc diameters greater than 10 μm, in freshwater is a ubiquitous phenomenon, causing the sedimentation of mud to be driven by changes in local hydrodynamics, and thus providing an explanation for how river systems construct landscapes through the deposition of mud in both coastal and upstream environments.
The Ostracod Clumped‐Isotope Thermometer: A Novel Tool to Accurately Quantify Continental Climate Changes
Authors: Marchegiano Marta , Peral Marion , Venderickx Jeroen , Martens Koen , García‐Alix Antonio , Snoeck Christophe , Goderis Steven , Claeys Philippe 
Published: February 2024

AbstractThis study presents a methodological advancement in the field of clumped‐isotope (∆47) thermometry, specifically tailored for application to freshwater ostracods. The novel ostracod clumped isotope approach enables quantitative temperature and hydrological reconstruction in lacustrine records. The relationship between ∆47 and the temperature at which ostracod shell mineralized is determined by measuring ∆47 on different species grown under controlled temperatures, ranging from 4 ± 0.8 to 23 ± 0.5ºC. The excellent agreement between the presented ∆47 ostracod data and the monitored temperatures confirms that ∆47 can be applied to ostracod shells and that a vital effect is absent outside the uncertainty of measurements. Results are consistent with the carbonate clumped‐isotope unified calibration (Anderson et al., 2021, https://doi.org/10.1029/2020gl092069), therefore, an ostracod‐specific calibration is not needed. The ostracod clumped‐isotope thermometer represents a powerful tool for terrestrial paleoclimate studies all around the world, as lakes and ostracods are found in all climatic belts.
Interannual Variations of the North Equatorial Current Across the Pacific Ocean
Authors: Liu Xueqi , Zhou Hui , Liu Hengchang 
Published: February 2024

AbstractThe interannual variation of the North Equatorial Current (NEC) across the North Pacific Ocean and the modulation of the Pacific Decadal Oscillation (PDO) are investigated based on both observations and reduced gravity model experiments. Results reveal that the interannual variation of the NEC is highly related to El Niño‐Southern Oscillation (ENSO) with unsynchronized variations both in zonal and meridional structure. The tropical and subtropical gyre branches of the NEC (NEC‐S and NEC‐N) behave antiphase variation during El Niño events with the transport of the former being enhanced and the latter being weakened across the Pacific. The NEC axis in the western/eastern Pacific shifts northward/southward during El Niño events, consistent with the meridional shift of the zero‐line of wind stress curl. Model experiments indicate that Rossby waves mainly modulate the NEC near the western boundary and the NEC‐N, while Ekman pumping modulates NEC‐S in the western basin. Meanwhile, the relationship between the interannual variation of the NEC and ENSO events is significantly modulated by different PDO phases. The PDO cold phase favors a much closer connection between the NEC and the Niño 3.4 index. The dynamics lie in that PDO‐related wind stress curl and sea level anomalies are consistent with that of El Niño, favoring the enhanced correlation between NEC and El Niño. The reverse is true for the warm phase. These results will contribute to a better understanding of the behavior of the tropical Pacific Ocean circulation and its role in climate change.
The Impact of Non‐Equilibrium Plasma Distributions on Solar Wind Measurements by Vigil's Plasma Analyser
Authors: Zhang H. , Verscharen D. , Nicolaou G. 
Published: February 2024

AbstractIn order to protect society from space weather impacts, we must monitor space weather and obtain early warnings for extreme events if possible. For this purpose, the European Space Agency is currently preparing to launch the Vigil mission toward the end of this decade as a space‐weather monitor at the fifth Lagrange point of the Sun–Earth system. Vigil will carry, amongst other instruments, the Plasma Analyser (PLA) to provide quasi‐continuous measurements of solar wind ions. We model the performance of the PLA instrument, considering typical solar wind plasma conditions, to compare the expected observations of PLA with the assumed input conditions of the solar wind. We evaluate the instrument performance under realistic, non‐equilibrium plasma conditions, accounting for temperature anisotropies, proton beams, and the contributions from α‐particles. We examine the accuracy of the instrument's performance over a range of input solar wind moments. We identify sources of potential errors due to non‐equilibrium plasma conditions and link these to instrument characteristics such as its angular and energy resolution and its field of view. We demonstrate the limitations of the instrument and potential improvements such as applying ground‐based fitting techniques to obtain more accurate measurements of the solar wind even under non‐equilibrium plasma conditions. The use of ground processing of plasma moments instead of on‐board processing is crucial for the extraction of reliable measurements.
RSPSSL: A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization
Authors: Hu Jiaqi , Chen Gina Jinna , Xue Chenlong , Liang Pei , Xiang Yanqun , Zhang Chuanlun , Chi Xiaokeng , Liu Guoying , Ye Yanfang , Cui Dongyu , Zhang De , yu Xiaojun , Dang Hong , Zhang Wen , Chen Junfan , Tang Quan , Guo Penglai , Ho Ho-Pui , Li Yuchao , Cong Longqing , Shum Perry Ping 
Published: February 2024

AbstractRaman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and technology. It is also an emerging omics technique for metabolic profiling to shape precision medicine. However, precisely attributing vibration peaks coupled with specific environmental, instrumental, and specimen noise is problematic. Intelligent Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information extraction. Here, we propose a novel Raman spectral preprocessing scheme based on self-supervised learning (RSPSSL) with high capacity and spectral fidelity. It can preprocess arbitrary Raman spectra without further training at a speed of ~1 900 spectra per second without human interference. The experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88% reduction in root mean square error and a 60% reduction in infinite norm ($${L}_{{\infty }}$$

L

∞

) compared to established techniques. With this advantage, it remarkably enhanced various biomedical applications with a 400% accuracy elevation (ΔAUC) in cancer diagnosis, an average 38% (few-shot) and 242% accuracy improvement in paraquat concentration prediction, and unsealed the chemical resolution of biomedical hyperspectral images, especially in the spectral fingerprint region. It precisely preprocessed various Raman spectra from different spectroscopy devices, laboratories, and diverse applications. This scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput, cross-device, various analyte complexity, and diverse applications.
Non-interleaved chiral metasurfaces and neural networks enhance the spatial resolution of polarimetry
Authors: Jang Jaewon , Park Minsu , Park Yeonsang 
Published: February 2024

AbstractNon-interleaved chiral metasurfaces for high-spatial-resolution polarimetry are proposed and demonstrated. Furthermore, a convolutional neural network is incorporated to analyze interferometric images with the polarization state of light, and it results in accurate Stokes parameters.
Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?
Authors: Janic Ana , Abad Etna , Amelio Ivano 
Published: February 2024

Abstract
Genomic instability, a hallmark of cancer, is a direct consequence of the inactivation of the tumor suppressor protein p53. Genetically modified mouse models and human tumor samples have revealed that p53 loss results in extensive chromosomal abnormalities, from copy number alterations to structural rearrangements. In this perspective article we explore the multifaceted relationship between p53, genomic stability, and epigenetic control, highlighting its significance in cancer biology. p53 emerges as a critical regulator of DNA repair mechanisms, influencing key components of repair pathways and directly participating in DNA repair processes. p53 role in genomic integrity however extends beyond its canonical functions. p53 influences also epigenetic landscape, where it modulates DNA methylation and histone modifications. This epigenetic control impacts the expression of genes involved in tumor suppression and oncogenesis. Notably, p53 ability to ensure cellular response to DNA demethylation contributes to the maintenance of genomic stability by preventing unscheduled transcription of repetitive non-coding genomic regions. This latter indicates a causative relationship between the control of epigenetic stability and the maintenance of genomic integrity in p53-mediated tumor suppression. Understanding these mechanisms offers promising avenues for innovative therapeutic strategies targeting epigenetic dysregulation in cancer and emphasizes the need for further research to unravel the complexities of this relationship. Ultimately, these insights hold the potential to transform cancer treatment and prevention strategies.
Enhancing detection of topological order by local error correction
Authors: Cong Iris , Maskara Nishad , Tran Minh C. , Pichler Hannes , Semeghini Giulia , Yelin Susanne F. , Choi Soonwon , Lukin Mikhail D. 
Published: February 2024

AbstractThe exploration of topologically-ordered states of matter is a long-standing goal at the interface of several subfields of the physical sciences. Such states feature intriguing physical properties such as long-range entanglement, emergent gauge fields and non-local correlations, and can aid in realization of scalable fault-tolerant quantum computation. However, these same features also make creation, detection, and characterization of topologically-ordered states particularly challenging. Motivated by recent experimental demonstrations, we introduce a paradigm for quantifying topological states—locally error-corrected decoration (LED)—by combining methods of error correction with ideas of renormalization-group flow. Our approach allows for efficient and robust identification of topological order, and is applicable in the presence of incoherent noise sources, making it particularly suitable for realistic experiments. We demonstrate the power of LED using numerical simulations of the toric code under a variety of perturbations. We subsequently apply it to an experimental realization, providing new insights into a quantum spin liquid created on a Rydberg-atom simulator. Finally, we extend LED to generic topological phases, including those with non-abelian order.
WASH interventions and child diarrhea at the interface of climate and socioeconomic position in Bangladesh
Authors: Ante-Testard Pearl Anne , Rerolle Francois , Nguyen Anna T. , Ashraf Sania , Parvez Sarker Masud , Naser Abu Mohammed , Benmarhnia Tarik , Rahman Mahbubur , Luby Stephen P. , Benjamin-Chung Jade , Arnold Benjamin F. 
Published: February 2024

AbstractMany diarrhea-causing pathogens are climate-sensitive, and populations with the lowest socioeconomic position (SEP) are often most vulnerable to climate-related transmission. Household Water, Sanitation, and Handwashing (WASH) interventions constitute one potential effective strategy to reduce child diarrhea, especially among low-income households. Capitalizing on a cluster randomized trial population (360 clusters, 4941 children with 8440 measurements) in rural Bangladesh, one of the world’s most climate-sensitive regions, we show that improved WASH substantially reduces diarrhea risk with largest benefits among children with lowest SEP and during the monsoon season. We extrapolated trial results to rural Bangladesh regions using high-resolution geospatial layers to identify areas most likely to benefit. Scaling up a similar intervention could prevent an estimated 734 (95% CI 385, 1085) cases per 1000 children per month during the seasonal monsoon, with marked regional heterogeneities. Here, we show how to extend large-scale trials to inform WASH strategies among climate-sensitive and low-income populations.
Recurrent evolutionary switches of mitochondrial cytochrome c maturation systems in Archaeplastida
Authors: Li Huang , Akella Soujanya , Engstler Carina , Omini Joy J. , Rodriguez Moira , Obata Toshihiro , Carrie Chris , Cerutti Heriberto , Mower Jeffrey P. 
Published: February 2024

AbstractMitochondrial cytochrome c maturation (CCM) requires heme attachment via distinct pathways termed systems I and III. The mosaic distribution of these systems in Archaeplastida raises questions about the genetic mechanisms and evolutionary forces promoting repeated evolution. Here, we show a recurrent shift from ancestral system I to the eukaryotic-specific holocytochrome c synthase (HCCS) of system III in 11 archaeplastid lineages. Archaeplastid HCCS is sufficient to rescue mutants of yeast system III and Arabidopsis system I. Algal HCCS mutants exhibit impaired growth and respiration, and altered biochemical and metabolic profiles, likely resulting from deficient CCM and reduced cytochrome c-dependent respiratory activity. Our findings demonstrate that archaeplastid HCCS homologs function as system III components in the absence of system I. These results elucidate the evolutionary trajectory and functional divergence of CCM pathways in Archaeplastida, providing insight into the causes, mechanisms, and consequences of repeated cooption of an entire biological pathway.
Impact of ageing on homologous and human-coronavirus-reactive antibodies after SARS-CoV-2 vaccination or infection
Authors: Zhou Fan , Vahokoski Juha ,   Bergen COVID-19 Research Group, Øyen Siri , Sævik Marianne , Høyland Hanne , Sandnes Helene H. , Madsen Anders , Brokstad Karl A. , Mohn Kristin G. I. , Tøndel Camilla , Langeland Nina , Cox Rebecca J. 
Published: February 2024

AbstractThe endemic human coronaviruses (HCoVs) circulate worldwide yet remain understudied and unmitigated. The observation of elevated levels of HCoV reactive antibodies in COVID-19 patients highlights the urgent necessity of better understanding of HCoV specific immunity. Here, we characterized in-depth the de novo SARS-CoV-2 specific antibody responses and the boosting of HCoV-reactive antibodies after SARS-CoV-2 vaccination or infection in individuals up to 98 years old. All the vaccinees were home-dwelling with no documented SARS-CoV-2 infection before receiving the COVID-19 mRNA vaccine (BNT162b2). The first two vaccine doses elicited potent SARS-CoV-2 spike binding antibodies in individuals up to 80 years. The third dose largely boosted the previously low S2 domain binding and neutralizing antibodies in elderly 80–90 years old, but less so in those above 90 years. The endemic betacoronavirus (HKU1 and OC43) reactive antibodies were boosted in all vaccinees, although to a lesser extent in those above 80 years old. COVID-19 patients had potent elevation of alpha- and betacoronavirus (229E, NL63, HKU1 and OC43) reactive antibodies. In both patients and vaccinees, S2 domain specific antibody increases correlated with SARS-CoV-2 neutralizing and HCoV-reactive antibody responses in all ages, indicating S2 domain as a candidate for future universal coronavirus vaccine design.
Emergent temperature sensitivity of soil organic carbon driven by mineral associations
Authors: Georgiou Katerina , Koven Charles D. , Wieder William R. , Hartman Melannie D. , Riley William J. , Pett-Ridge Jennifer , Bouskill Nicholas J. , Abramoff Rose Z. , Slessarev Eric W. , Ahlström Anders , Parton William J. , Pellegrini Adam F. A. , Pierson Derek , Sulman Benjamin N. , Zhu Qing , Jackson Robert B. 
Published: February 2024

AbstractSoil organic matter decomposition and its interactions with climate depend on whether the organic matter is associated with soil minerals. However, data limitations have hindered global-scale analyses of mineral-associated and particulate soil organic carbon pools and their benchmarking in Earth system models used to estimate carbon cycle–climate feedbacks. Here we analyse observationally derived global estimates of soil carbon pools to quantify their relative proportions and compute their climatological temperature sensitivities as the decline in carbon with increasing temperature. We find that the climatological temperature sensitivity of particulate carbon is on average 28% higher than that of mineral-associated carbon, and up to 53% higher in cool climates. Moreover, the distribution of carbon between these underlying soil carbon pools drives the emergent climatological temperature sensitivity of bulk soil carbon stocks. However, global models vary widely in their predictions of soil carbon pool distributions. We show that the global proportion of model pools that are conceptually similar to mineral-protected carbon ranges from 16 to 85% across Earth system models from the Coupled Model Intercomparison Project Phase 6 and offline land models, with implications for bulk soil carbon ages and ecosystem responsiveness. To improve projections of carbon cycle–climate feedbacks, it is imperative to assess underlying soil carbon pools to accurately predict the distribution and vulnerability of soil carbon.