bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of furmonertinib in untreated advanced NSCLC patients with sensitive EGFR mutations in a real-world setting: a single institutional experience
Authors: Yan Ningning , Guo Sanxing , Huang Siyuan , Zhang Huixian , Li Xingya 
Published: February 2024

BackgroundFurmonertinib is the standard treatment option in the first-line setting for advanced non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor (EGFR) mutations in China. However, there are limited real-world data available.MethodsWe conducted a retrospective study at a single center, analyzing a cohort of 73 NSCLC patients who tested positive for EGFR mutations and were treated with furmonertinib as their initial therapy between August 2022 and December 2023. The primary endpoint was progression-free survival (PFS), with secondary endpoints including objective response rate (ORR), overall survival (OS), and safety profile.ResultsThe median observation period was 9 months (95% confidence interval [CI], 8.0–20.0). The median PFS was 19.5 months (95% CI, 14.6–24.4). OS data were not yet mature. Univariate analysis showed no significant correlation between PFS and factors such as Eastern Cooperative Oncology Group performance status (ECOG PS) score, presence of brain or liver metastases, sex, age, EGFR mutation status, or number of metastatic sites. However, multivariate analysis indicated a potential trend toward extended PFS in patients younger than 65 years (p = 0.053, 95% CI, 0.10–1.02), although the p-value was only marginally significant. The most common adverse events were diarrhea (24%), anemia (36%), and liver injury (32%); however, only four cases experienced severe adverse events.ConclusionIn a real-world setting, furmonertinib appears to be a favorable treatment option for EGFR-mutated patients. The manageable nature of adverse events further supports its use in clinical practice.
Pain, comorbidities, and clinical decision-making: conceptualization, development, and pilot testing of the Pain in Aging, Educational Assessment of Need instrument
Authors: Siaton Bernadette C. , Hogans Beth B. , Frey-Law Laura A. , Brown Lana M. , Herndon Christopher M. , Buenaver Luis F. 
Published: February 2024

IntroductionPain is highly prevalent in older adults and often contextualized by multiple clinical conditions (pain comorbidities). Pain comorbidities increase with age and this makes clinical decisions more complex. To address gaps in clinical training and geriatric pain management, we established the Pain in Aging—Educational Assessment of Need (PAEAN) project to appraise the impacts of medical and mental health conditions on clinical decision-making regarding older adults with pain. We here report development and pilot testing of the PAEAN survey instrument to assess clinician perspectives.MethodsMixed-methods approaches were used. Scoping review methodology was applied to appraise both research literature and selected Medicare-based data. A geographically and professionally diverse interprofessional advisory panel of experts in pain research, medical education, and geriatrics was formed to advise development of the list of pain comorbidities potentially impacting healthcare professional clinical decision-making. A survey instrument was developed, and pilot tested by diverse licensed healthcare practitioners from 2 institutions. Respondents were asked to rate agreement regarding clinical decision-making impact using a 5-point Likert scale. Items were scored for percent agreement.ResultsScoping reviews indicated that pain conditions and comorbidities are prevalent in older adults but not universally recognized. We found no research literature directly guiding pain educators in designing pain education modules that mirror older adult clinical complexity. The interprofessional advisory panel identified 26 common clinical conditions for inclusion in the pilot PAEAN instrument. Conditions fell into three main categories: “major medical”, i.e., cardio-vascular-pulmonary; metabolic; and neuropsychiatric/age-related. The instrument was pilot tested by surveying clinically active healthcare providers, e.g., physicians, nurse practitioners, who all responded completely. Median survey completion time was less than 3 min.ConclusionThis study, developing and pilot testing our “Pain in Aging—Educational Assessment of Need” (PAEAN) instrument, suggests that 1) many clinical conditions impact pain clinical decision-making, and 2) surveying healthcare practitioners about the impact of pain comorbidities on clinical decision-making for older adults is highly feasible. Given the challenges intrinsic to safe and effective clinical care of older adults with pain, and attendant risks, together with the paucity of existing relevant work, much more education and research are needed.
Effects of whole-body electromyostimulation with different impulse intensity on blood pressure changes in hyper- and normotensive overweight people. A pilot study
Authors: Kemmler Wolfgang , Kohl Matthias , von Stengel Simon , Willert Sebastian , Kast Stephanie , Uder Michael 
Published: February 2024

Hypertension is a frequent condition in untrained middle-aged to older adults, who form the core group of whole-body electromyostimulation (WB-EMS) applicants. So far, the acute effects of varying impulse intensities on blood pressure responses have not been evaluated in normo- and hypertensive people. Thirteen hypertensive and twelve normotensive overweight WB-EMS novices, 40–70 years old, conducted the same WB-EMS protocol (20 min, bipolar, 85 Hz, 350 µs, 4 s impulse-4 s rest; combined with easy movements) with increasing impulse intensity (low, moderate, advanced) per session. Mean arterial blood pressure (MAP) as determined by automatic sphygmomanometry rose significantly (p &lt; .001) from rest, 5 min pre-WB-EMS to immediately pre-WB-EMS assessment. Of importance, a 20-min WB-EMS application does not increase MAP further. In detail, maximum individual MAP does not exceed 128 mmHg (177 mmHg systolic or 110 mmHg diastolic) in any case. Two-min post-WB-EMS, MAP was significantly lower (p = .016) compared to immediately pre-WB-EMS. In contrast, heart rate increased significantly from immediately pre to immediately post-exercise (p &lt; .001), though individual peak values did not exceed 140 beats/min−1 and heart rate decreased rapidly (p &lt; .001) post-exercise. No significant differences in MAP and HR kinetics were observed for impulse intensity categories or hypertensive status. In summary, largely independently of impulse intensity and status, the acute effect of WB-EMS on MAP in novice applicants seem to be largely negligible. Although definite evidence might not have been provided by the present study, we conclude that hypertension, at least under treatment, should not be considered as a barrier for WB-EMS application in moderately old or older cohorts.
Triangular osteosynthesis and lumbopelvic fixation as a valid surgical treatment in posterior pelvic ring lesions: a systematic review
Authors: Rovere Giuseppe , De Mauro Domenico , Smakaj Amarildo , Sassara Giulia , De Vitis Rocco , Farsetti Pasquale , Camarda Lawrence , Maccauro Giulio , Liuzza Francesco 
Published: February 2024

ObjectiveUnstable fractures of the sacrum often occur in patients with pelvic fractures and represent a real challenge for the orthopedic surgeon. Triangular osteosynthesis (TOS) and lumbopelvic fixation (LP) may represent a valid management option for the treatment of this condition. We present a systematic literature review about lumbopelvic fixation and triangular fixation as treatment option for unstable sacral fractures, to assess clinical and radiological outcomes after surgery and to evaluate appropriate indications and impact on the natural history of sacral fractures.MethodsThe review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 50 articles out of 108 titles, were considered eligible for the full-text analysis. Finally, 16 studies that met inclusion criteria were included in this review.ResultsOverall, 212 patients (87 males, 58 females) with sacral fractures treated with TOS triangular fixation or LP lumbopelvic fixation were collected. The mean age was 37.6 years. Mean follow-up reported in all studies was 24.14 months.ConclusionThe results presented by the different authors, highlight the effectiveness of TOS triangular fixation and LP lumbopelvic fixation for the treatment of unstable sacral fractures associated with other pelvic fractures, in terms of function, stability, cost-effectiveness, and quality of life postoperatively.
Ship Speed Optimization Method in Canal Environments Considering Waiting Times for Crossing Locks
Authors: Xie Wen , Xu Sudong , Zhang Nini , Liu Jun , Yin Kai , Mao Liuyan 
Published: February 2024

The shipping industry faces a pressing challenge with carbon emissions, prompting a focus on speed optimization for energy conservation and emission reduction. While much research has centered on optimizing speeds in oceans and rivers, canals have received less attention, despite their unique challenges of narrow waterways and busy locks. This study fills this gap by establishing a fuel consumption prediction model integrating key environmental factors such as water depth, width, and flow velocity. Drawing upon established methodologies in speed optimization, this study augments these models with waiting time limits for each canal segment. To validate the efficacy of the model, three representative ships are selected as case studies. The findings reveal a high predictive capability of the fuel consumption model, as evidenced by R2 values exceeding 0.97 across all cases. Notably, the optimization approach yields a fuel consumption reduction ranging from 4% to 5% for short waiting times. Furthermore, compared to conventional methods, the proposed optimization strategy achieves an 8.19% enhancement in fuel consumption and carbon emission reduction for long waiting times, culminating in an overall optimization rate of 11.54%. These results underscore the significance of employing the proposed speed optimization methodology, particularly during peak periods of canal congestion.
ВЛИЯНИЕ НАПОЛНИТЕЛЕЙ ИЗ УГЛЕРОДНЫХ ВОЛОКОН И КЕРАМИЧЕСКИХ МИКРОСФЕР НА ФИЗИКО-МЕХАНИЧЕСКИЕ СВОЙСТВА КОМПОЗИЦИОННЫХ МАТЕРИАЛОВ ТЕПЛОЗАЩИТНЫХ ПОКРЫТИЙ
Authors: М.М. Элькади  , П.И. Лобода  , И.М. Гурия  , И.Ю. Тросникова  
Published: February 2024

Исследованы физико-механические свойства материалов теплозащитных покрытий, работающих в условиях экстремально высоких температур. Установлено, что использование смеси керамических пустотелых микросфер в фенолформальдегидной матрице позволит получить полимерный композиционный материал с низкими показателями теплопроводности. Показано, что введение 5 мас.% керамических пустотелых микросфер увеличивает прочностные характеристики при сжатии на 20%, а показатели теплопроводности снижает на 40%.
АНАЛІЗ РІВНЯНЬ ПРЕСУВАННЯ ПЛАКОВАНИХ ЗАЛІЗНИХ ПОРОШКІВ
Authors: А.В.Мініцький  , Д.В.Ведель  , О.В. Степанов  , Н.В.Мініцька  
Published: February 2024

В роботі проведено аналіз ущільненості залізного порошку плакованого міддю за допомогою основних математичних рівнянь, що описують процеси деформації пористого тіла, як залежність щільності від тиску пресування. Застосовано основні теоретичні положення, що описують щільність порошкового тіла як функцію від тиску до яких відносяться рівняння Куніна-Юрченка, Бальшина М.Ю., Ждановича Г.М. та Штерна М.Б. Показано, що характер ущільнення залізного порошку плакованого міддю відрізняється від ущільнення однокомпонентного залізного порошку, що обумовлено тим, що для композиційних порошків залізо – мідь переважають механізми пластичної деформації. Встановлено, що структура пресовок із композиційних залізних порошків де мідь виступає пластичним прошарком, максимально наближена до суцільного континууму і коректно описується рівнянням, що базується на теорії суцільності середовища, що стискається.
Impact of Despotic Leadership on Workplace Incivility: Serial Mediation of Stress and Emotional Exhaustion
Authors: Raza Muhammad Ali , Imran Muhammad , Ul Hadi Noor 
Published: February 2024

Purpose: Considering the importance of despotic leadership to employees’ negative outcomes, this study explored how despotic leadership affects workplace incivility. Drawing on the dark side of leadership, the current study conceptualizes a model to explore the mechanism underlining the despotic leadership and workplace incivility relationship.
Design/Methodology: A cross-lagged survey approach was employed to collect data from 249 employees through questionnaires from Pakistan’s healthcare sector. Model based on structural equation was employed for data analysis.
Findings: Results of the study indicate that employees working in the health sector perceive incivility as a foremost consequence of despotic leadership, stress and emotional exhaustion.
Originality: This research painted a more comprehensive picture of despotic leadership and workplace incivility relationship in the health sector. We conclude that leveraging the bright side while acknowledging the dark side of leadership is an appropriate coping strategy to deal with workplace incivility. The aim of this study is to understand relationship between despotic leadership (DL) and workplace incivility (WI) with serial mediation of stress and emotional exhaustion (EE) in healthcare sector. The study strives to present empirical evidence for negative impact of DL on WI and its toll on employee performance.
What Literature Has to Say about Supply Chain Finance (SCF): A Bibliometric Review of Supply Chain Finance
Authors: Javed Hassan , Wasim Muhammad 
Published: February 2024

Purpose: The current research aims at reviewing Supply Chain Finance (SCF) which is an advanced domain of supply chain management receiving extensive attention in research nowadays.
Design/Methodology: Comprising an in-depth analysis of different concepts, approaches, and methodologies being used in the domain of SCF, the present evaluation is based on a review of 58 research articles published in the domain of SCF at various times. Comprehensive data regarding the utilization of SCF has been gathered from earlier and more recent studies
Findings: The study identifies the areas and domains of supply chain finance which have hitherto received limited attention. The findings show that there is still much left for future researchers to investigate in the area of SCF.
Originality: The present review also maps and identifies possible directions for future research. Future researchers may investigate the novel areas identified within SCF. the research provides insights into the supply chain finance field with possible future workings.
Follow-up on the Supermassive Black Hole Binary Candidate J1048+7143: Successful Prediction of the Next Gamma-Ray Flare and Refined Binary Parameters in the Framework of the Jet Precession Model
Authors: Kun Emma , Jaroschewski Ilja , Tjus Julia Becker , Britzen Silke , Frey Sándor , Gabányi Krisztina Éva , Cui Lang , Wang Xin , Shen Yuling 
Published: February 2024

Abstract
Analyzing single-dish and very long baseline interferometry radio, as well as Fermi Large Area Telescope γ-ray observations, we explained the three major flares in the γ-ray light curve of FSRQ J1048+7143 with the spin–orbit precession of the dominant mass black hole in a supermassive black hole binary system. Here, we report on the detection of a fourth γ-ray flare from J1048+7143, appearing in the time interval that was predicted in our previous work. Including this new flare, we constrained the mass ratio into a narrow range of 0.062 < q < 0.088, and consequently we were able to further constrain the parameters of the hypothetical supermassive binary black hole at the heart of J1048+7143. We predict the occurrence of the fifth major γ-ray flare that would appear only if the jet will still lay close to our line of sight. The fourth major γ-ray flare also shows the two-subflare structure, further strengthening our scenario in which the occurrence of the subflares is the signature of the precession of a spine–sheath jet structure that quasiperiodically interacts with a proton target, e.g., clouds in the broad-line region.
The Strength and Shapes of Contact Binary Objects
Authors: Meyer Alex J. , Scheeres Daniel J. 
Published: February 2024

Abstract
While contact binary objects are common in the solar system, their formation mechanism is unclear. In this work we examine several contact binaries and calculate the necessary strength parameters that allow the two lobes to merge without the smaller of the two being gravitationally destroyed by the larger. We find a small but nonzero amount of cohesion or a large friction angle is required for the smaller lobe to survive the merging process, consistent with observations. This means it is possible for two previously separated rubble piles to experience a collapse of their mutual orbit and form a contact binary. The necessary strength required to survive this merger depends on the relative size, shape, and density of the body, with prolate shapes requiring more cohesion than oblate shapes.
Drilling In Supercharged Reservoir – A Novel Approach Raising the Bar of Operational Excellence In Kuwait Oilfield
Authors: Al Shelian Jasim M. , Alhafedh Bader O. , Goswami Bijan , Al Naqa Faisal A. 
Published: February 2024

It is a regular practice to close the nearby Injector wells prior to drilling any reservoir section to avoid encountering any abnormal pressure due to injection, which may create complications like well-control. However, shutting down injection for long period certainly creates negative impact on productivity & reservoir pressure management. This paper reveals innovative approach in drilling such wells without closing any injectors while ensuring safe and trouble-free operations in a matured field in North Kuwait.
This paper elaborates on the methodology to safely drill into a charged-up reservoir from planning till execution stage. A formation-wise pressure mapping was developed with collaboration from Reservoir Engineering team with zone-wise color coding based on severity of reservoir pressure. In the planning phase, any upcoming well could be plotted in this map which will instantly give an idea about likely pressure regime to be encountered. In execution phase, real-time BHP is acquired from nearby wells with Slick-line. Finally pressure data from the landing section of subject wells is recorded to decide accurate Mud density for smoothly drilling through reservoir.
This procedure was successfully applied in two field trials right from planning till completion of drilling in the North Kuwait field. Based on lessons learnt, this innovative and cost effective practice is expected to be implemented for all upcoming wells in Kuwait.
Drilling Optimization in Mahakam Offshore Field Indonesia by Combining Multiple Shaped Geometry PDC Cutters and Motorized Rotary Steerable System Resulting in Step Change Performance and Substantial Value Creation.
Authors: Hermawan Aditia , Nurmida Arrofi , Yusicha Yasir , Kartaatmadja Himawan , Agriawan Crisa , Wijayanto Timora , Noviasta Bonar 
Published: February 2024

Abstract
Under the marginal remaining reserve condition, Pertamina Hulu Mahakam has been constantly initiating the ways to improve drilling efficiency thru sidetrack well. In the Q4 2022 to Q1 2023, sidetrack drilling campaign was conducted in existing Jempang Metulang (JM-1) platform, South Mahakam Field, which known as the most challenging among other Mahakam offshore fields.
This paper provides a case study of performance improvement of five cased hole sidetrack wells (milling out 9-5/8in casing and drilling 8-1/2in hole section subsequently). The study started by analyzing main drilling problems in the field in which many offset wells experienced multiple BHA runs and severely low rate of penetration (ROP). The average OB ROP in the previous campaign was only 13 m/hr with maximum achievement 1,200-2,400 meters drilling interval per BHA run. In 2023 sidetrack drilling campaign, the main drilling objective is to achieve one-run to well TD, increase OB ROP and optimize well architecture design to drill with single 8-1/2in open hole. Several initiatives were then implemented of motorized RSS BHA utilization, fit-for-purpose bit selection design and proper job execution by applying optimum drilling parameter.
The result of thorough improvement process follow-up shows a significant well cost reduction up to 10.4 MUSD including improvement 159% OB ROP with fastest value 40.6 m/hr. A new drilling record was achieved for longest 8-1/2in hole section of 3,346 meters in one run to well TD. On top of that, all the initiatives have been executed in a safe manner without any major operation issues and successfully unlock remaining marginal reserve to prolong the sustainability of Mahakam.
Unleashing the Sky Potential: Revolutionizing Construction with Drones
Authors: Fong Chen Khian , Kadzim Rosdi , Endot Ernyza 
Published: February 2024

Objectives/Scope
This paper aims to provide an insight on the use of drones in digital construction, specifically focusing on their application in the engineering construction work of 100 hectares onshore gas plant. The objective of the project is to utilize drones for photogrammetry data collection, including surveying, mapping, and inspection; and to enhance project planning, monitoring, and quality control. Final products generated will provide an enhanced visualization for easy analysis and view of the project.
Navigating Complexity: Planning and Execution of the Longest ERD Well with Open Hole Completion Design in India's West Coast Cambay Offshore Field
Authors: Bhosale Saurabh , Misra Anurag , Ranjan Ashish 
Published: February 2024

Abstract
The planning and execution of an Extended Reach Drilling (ERD) project in the Cambay field presented numerous challenges due to the confined nature of the well and the objective of accessing previously untapped reserves. With a step-out ratio of 3:1, indicating a significant increase in complexity compared to conventional Drilling, careful consideration was given to the well path trajectory, casing seat selection, and open hole size selection during the initial planning phase. These critical aspects played a pivotal role in identifying and addressing the unique challenges inherent in ERD operations which necessitated the application of innovative techniques for mitigation. Given the intricate structure of the extended reach well, the key hurdles include torque and drag issues, hole cleaning, casing running, equivalent circulation density control, bottom hole assembly stuck, side tracking, wellbore stability, and well activation with coiled tubing and/or Eline based tractor stroker intervention. These challenges were overcome with deployment of cutting-edge technology in Drilling viz. application of drill pipe severing tool (DPST) & under reamer tool and in Completion viz, shearable gas lift valves, trimmed swell packers, auto lift gas technology, and tapered string coiled tubing. The well also witnessed some complex fishing operation to retrieve stuck Eline tractor tool which was a difficult undertaking.
The paper will summarize the ERD project, outlining the methods, challenges, and technologies used while effectively Drilling and successful Completion of the longest ERD well in the offshore region along India's west coast, with a recorded measured depth of 3,830.79 meters. It will also provide vital insights and lessons acquired from the extensive Drilling and Completion procedures, adding to the knowledge base, and providing as a roadmap for future ERD initiatives of a similar nature.