bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Disunity of Science and the Unity of the World Presidential Address, PSA 2022
Authors: Dupré John 
Published: October 2023

AbstractThis paper recapitulates earlier work in which I argued for the disunity of science, the plurality of partly incommensurable ways in which the world can be conceptualised for scientific purposes. It then aims to show how this plurality is intelligible, even to be expected, from the perspective of a process philosophy that sees the world as largely disorganised, but as allowing the emergence of pockets of stability, most notably the stability provided by biological organisms. It incidentally aims to demonstrate the importance to one another of science and metaphysics.
Niche development: the International Foundation for Science and the road to Sweden
Authors: Beckman Jenny 
Published: October 2023

AbstractThis paper examines the crowded landscape of conferences and organizations within which the International Foundation for Science (IFS) was shaped in the early 1970s. The IFS aimed to support scientists from developing countries, circumventing the bureaucracy of established international organizations such as UNESCO and the Organization for Economic Co-operation and Development (OECD). The new foundation was a potential rival to such institutions, which ironically provided the conditions essential to its emergence. Their conferences, board meetings and assemblies, where scientists and policy makers convened, provided key infrastructure for the development of the IFS. This infrastructure appears simultaneously both as an almost invisible feature of international science policy, and as a political problem. The solution to this problem was Stockholm: a geographical place that was also placeless, occupying both national and international status, desirable in its political, scientific and geographical neutrality. In an organizational context, academies and scientific societies who found their role circumscribed by existing international institutions used the IFS to argue for their particular role and expertise in funding and promoting scientific development. Geographically and politically, neutral Sweden provided a setting which was located between East and West, and which added to the country's own reputation for championing the causes of developing nations.
Trematode genetic patterns at host individual and population scales provide insights about infection mechanisms
Authors: Correia Simão , Fernández-Boo Sergio , Magalhães Luísa , de Montaudouin Xavier , Daffe Guillemine , Poulin Robert , Vera Manuel 
Published: October 2023

AbstractMultiple parasites can infect a single host, creating a dynamic environment where each parasite must compete over host resources. Such interactions can cause greater harm to the host than single infections and can also have negative consequences for the parasites themselves. In their first intermediate hosts, trematodes multiply asexually and can eventually reach up to 20% of the host's biomass. In most species, it is unclear whether this biomass results from a single infection or co-infection by 2 or more infective stages (miracidia), the latter being more likely a priori in areas where prevalence of infection is high. Using as model system the trematode Bucephalus minimus and its first intermediate host cockles, we examined the genetic diversity of the cytochrome c oxidase subunit I region in B. minimus from 3 distinct geographical areas and performed a phylogeographic study of B. minimus populations along the Northeast Atlantic coast. Within localities, the high genetic variability found across trematodes infecting different individual cockles, compared to the absence of variability within the same host, suggests that infections could be generally originating from a single miracidium. On a large spatial scale, we uncovered significant population structure of B. minimus, specifically between the north and south of Bay of Biscay. Although other explanations are possible, we suggest this pattern may be driven by the population structure of the final host.
Effect of next-step antidepressant treatment on suicidal ideation: findings from the VAST-D trial
Authors: Zisook Sidney , Moutier Christine Yu , Rush A. John , Johnson Gary R , Tal Ilanit , Chen PJ. , Davis Lori L , Hicks Paul B , Wilcox James , Planeta Beata , Lauro Kimberly (Weingart) , Scrymgeour Alexandra A. , Kasckow John , Mohamed Somaia 
Published: October 2023

AbstractBackgroundMajor depressive disorder (MDD) contributes to suicide risk. Treating MDD effectively is considered a key suicide prevention intervention. Yet many patients with MDD do not respond to their initial medication and require a ‘next-step’. The relationship between next-step treatments and suicidal thoughts and behaviors is uncharted.MethodThe VA Augmentation and Switching Treatments for Depression trial randomized 1522 participants to one of three next-step treatments: Switching to Bupropion, combining with Bupropion, and augmenting with Aripiprazole. In this secondary analysis, features associated with lifetime suicidal ideation (SI) and attempts (SA) at baseline and current SI during treatment were explored.ResultsCompared to those with SI only, those with lifetime SI + SA were more likely to be female, divorced, or separated, unemployed; and to have experienced more childhood adversity. They had a more severe depressive episode and were more likely to respond to ‘next-step’ treatment. The prevalence of SI decreased from 46.5% (694/1492) at baseline to 21.1% (315/1492) at end-of-treatment. SI during treatment was associated with baseline SI; low positive mental health, more anxiety, greater severity and longer duration of current MDD episode; being male and White; and treatment with S-BUP or C-BUP as compared to A-ARI.ConclusionSI declines for most patients during next-step medication treatments. But about 1 in 5 experienced emergent or worsening SI during treatment, so vigilance for suicide risk through the entire 12-week acute treatment period is necessary. Treatment selection may affect the risk of SI.
On a retrial queue with negative customers, passive breakdown, and delayed repairs
Authors: Han Yunna , Tian Ruiling , Wu Xinyu , He Liuqing 
Published: October 2023

AbstractThis paper studies an M/M/1 retrial queue with negative customers, passive breakdown, and delayed repairs. Assume that the breakdown behavior of the server during idle periods is different from that during busy periods. Passive breakdowns may occur when the server is idle, due to the lack of monitoring of the server during idle periods. When the passive breakdown occurs, the server does not get repaired immediately and enters a delayed repair phase. Negative customers arrive during the busy period, which will cause the server to break down and remove the serving customers. Under steady-state conditions, we obtain explicit expressions of the probability generating functions for the steady-state distribution, together with some important performance measures for the system. In addition, we present some numerical examples to illustrate the effects of some system parameters on important performance measures and the cost function. Finally, based on the reward-cost structure, we discuss Nash equilibrium and socially optimal strategy and numerically analyze the influence of system parameters on optimal strategies and optimal social benefits.
Nuclear DNA-based phylogenetic analysis of Neocinnamomum species
Authors: Li Qishao , Yang Linyi , Yu Qunfei , Xu Wenbin , Xin Yaxuan , Song Yu , Xin Peiyao 
Published: October 2023

AbstractNeocinnamomum plants are evergreen shrubs or small trees belonging to the Neocinnamomeae tribe of the Lauraceae family. Their seeds are rich in fatty acids, and their leaves are often used in traditional Chinese medicine. Presently, only a few studies have been performed on Neocinnamomum plants; therefore, the genome-based phylogeny among Neocinnamomum species has not been determined, which limits the germplasm innovation of this genus. In this study, by the Illumina (next-generation sequencing) and third-generation sequencing technologies, the whole genomes of seven Neocinnamomum species samples were sequenced, their nuclear DNA (nrDNA) sequences were assembled and characterized, and their phylogeny was reconstructed. The results revealed four hypervariable regions (i.e. transcribed spacer regions) in the nrDNA sequences, among which the highest degree of variation was observed in the external transcribed spacer (ETS) region localized behind the 26S gene. A total of 27 insertions/deletions and 184 single-nucleotide polymorphisms, both localized mainly in the ETS and internal transcribed spacer regions, were identified. Phylogenetic trees were constructed based on the nrDNA sequences using the maximum likelihood (ML) and Bayesian inference (BI) methods with Caryodaphnopsis henryi as the outgroup. The ML tree divided the seven Neocinnamomum species into four clades. Clade I consisted of Neocinnamomum caudatum var. macrocarpum and Neocinnamomum caudatum, clade II included Neocinnamomum delavayi and Neocinnamomum mekongense, clade III included Neocinnamomum fargesii and a branch species of N. delavayi and clade IV included Neocinnamomum lecomtei, constituting a monophyletic and basal group. The BI tree shared the same topological structure as the ML tree, and all the support values of the BI tree were one except for that of one Neocinnamomum species (0.98). The results of this study provide new evidence regarding the phylogenetic evolution of the Neocinnamomum plants.
Implementing dialectical behaviour therapy in routine practice: an evaluation of a national CAMHS DBT service for adolescents
Authors: Camp J. , Hunt K. , Smith L.M. 
Published: October 2023

Abstract
Self-harming behaviours are reported to be increasing amongst young people and are associated with increased risk of suicide. The recently published UK clinical guidelines highlight that cross-sector awareness and early psychosocial assessment of self-harming is necessary, alongside careful triaging as to the level of support required. Dialectical behaviour therapy for adolescents (DBT-A) is a recommended intervention for young people with more severe difficulties. The current study aims to contribute to the data available to inform ongoing clinical decisions about the feasibility and implementation of DBT-A by reporting the intervention method, participant characteristics, and clinical outcomes of a national (UK) DBT service for young people with high levels of need and risk. Young people who commenced treatment between 2015 and 2021 were included. Completion rates, reasons for non-completion, and discharge pathways are reported. Measurement and changes in outcomes, including self-harm, in-patient bed days, accident and emergency department attendances and education/work status, are reported, as well as for routine outcome measures assessing emotion dysregulation and symptoms of emerging borderline personality disorder, depression and anxiety. The clinical significance of these outcomes are considered. Ideas for service evaluation, which are feasible and replicable in busy clinical settings are proposed, as well as a discussion of potential adaptations to standardised protocols needed in this context to fit with National Health Service (NHS) resources and the needs of the target population.

Key learning aims

(1)
To learn about the implementation of dialectical behaviour therapy (DBT) and concurrent outcome monitoring in a UK National Health Service CAMHS out-patient setting.

(2)
To understand the clinical profile and response to treatment of young people with high levels of suicidal and non-suicidal self-harming behaviours.

(3)
To present a potential method for outcome monitoring and collection for CAMHS DBT services.
Genetic and Familial Influences on Self-Perception in Early Childhood and Self-Esteem in Adulthood: A Cross-Sectional Analysis
Authors: Marshall Riley L. , DiLalla Lisabeth Fisher , Harbke Colin R. , Pali Emily C. 
Published: October 2023

AbstractSelf-perception in early childhood and self-esteem in adulthood are related to a variety of aspects of psychological wellbeing. The goal of the present study was to examine genetic and familial influences on self-perception and self-esteem in separate samples of children (153 twin pairs of 5-year-olds) and adults (753 twin pairs between the ages of 25–75 years). Genetic common factor modeling showed that three facets of self-perception (physical competence, peer acceptance, and maternal acceptance) loaded onto a single heritable factor in children. Multilevel modeling showed no effects of self or co-twin sex on self-perception, but authoritative parenting style was negatively related to self-perception in boys. Similarly, in Study 2, with the adult sample, five self-esteem items loaded on a single heritable factor with no effects of co-twin sex on adult self-esteem. Remembered maternal affection, paternal affection, and maternal discipline were positively related to self-esteem in adults; maternal affection was especially significant for women. The reversal in direction of parenting effects between early childhood and adulthood suggests that parents may play different roles in shaping how children and adults think of themselves. These results suggest that self-perception in childhood and self-esteem in adulthood are both influenced by genetic and environmental factors and that parenting is an important environmental factor for both children and adults.
Spatial Organisation Affects the Pathway to Precipitation in Simulated Trade‐Wind Convection
Authors: Radtke Jule , Vogel Raphaela , Ament Felix , Naumann Ann Kristin 
Published: October 2023

AbstractWe investigate whether and how spatial organization affects the pathway to precipitation in large‐domain hectometer simulations of the North Atlantic trades. We decompose the development of surface precipitation (P) in warm shallow trade cumulus into a formation phase, where cloud condensate is converted into rain, and a sedimentation phase, where rain falls toward the ground while some of it evaporates. With strengthened organization, rain forms in weaker updrafts from smaller cloud droplets so that cloud condensate is less efficiently converted into rain. At the same time, organization creates a locally moister environment and modulates the microphysical conversion processes that determine the raindrops' size. This reduces evaporation and more of the formed rain reaches the ground. Organization thus affects how the two phases contribute to P, but only weakly affects the total precipitation efficiency. We conclude that the pathway to precipitation differs with organization and suggest that organization buffers rain development.
Unveiling Geomagnetic Reversals: Insights From Tipping Points Theory
Authors: Alberti T. , Florindo F. , De Michelis P. , Consolini G. 
Published: October 2023

AbstractThe geomagnetic field shows aperiodic reversals and excursions separated by stable polarity periods. Although the exact mechanisms responsible of reversals are still debated, several models of different complexity have been proposed. Here we use, for the first time, a different and novel approach based on the theory of tipping points to detect and characterize geomagnetic reversals occurred during the period 25–36 millions years ago by using a high‐resolution magnetostratigraphic study conducted on a sedimentary section located on Maud Rise in the Southern Ocean. We detect a critical threshold for an early warning indicator of the occurrence of a polarity reversal below which a polarity reversal starts. Through the proper use of this early warning indicator we build up a simple non‐autonomous stochastic model to describe the main features of polarity reversals. This approach could be helpful for building up a novel framework for paleomagnetic studies.
Plasma‐Sheet Bubble Identification Using Multivariate Time Series Classification
Authors: Feng Xuedong , Yang Jian 
Published: October 2023

AbstractPlasma‐sheet bubbles play a major role in the earthward transport of magnetotail particles. The most remarkable feature of bubbles is their fast bulk flow velocities, along with reduced plasma density and pressure accompanied by magnetic field dipolarization. These bubbles can be identified based on in situ observations, but subjective ambiguity necessitates human verification, due to confusion with other phenomena mostly associated with magnetic reconnection and plasma waves. In this study, we aim to employ machine learning (ML) techniques to detect bubbles automatically and to create a tool that can be utilized by individuals without specialized subject expertise. To identify bubbles, we combine three distinct techniques: MINImally RandOm Convolutional KErnel Transform (MINIROCKET), 1D convolution neural network, and Residual Network (ResNet). The imbalanced training data set consists of bubble and non‐bubble events with a ratio of 1:40 from 2007 to 2020. The results indicate that the accuracy of all three models is approximately 99%, and their precision, recall, and F2 score are all above 80% for both the validation and test datasets. The three methods are combined with the intersection set as the minimum set of predictions and the union set as the maximum set. The union set can accurately identify 66.7% of bubbles. The combined method reduces the number of false negatives significantly. In the prediction of bubbles in observations made in the year 2021 using a union set, the bubbles obtained by the model are comparable to those discovered using traditional criteria and manual inspections.
Dust Lifting Observations With the Mars Science Laboratory Navigation Cameras
Authors: Guzewich Scott D. , Mason Emily L. , Lemmon Mark T. , Newman Claire E. , Lewis Kevin W. 
Published: October 2023

AbstractMartian dust lifting is believed to occur through two primary mechanisms: dust devils and wind stress forced dust lifting. Gale Crater's varied terrain and meteorology provide a unique in situ perspective on Martian dust lifting, with the Mars Science Laboratory Curiosity rover passing through both conditions and locations detrimental to dust lifting (e.g., the crater floor) and those with active sand motion and frequent dust lifting (e.g., the Bagnold Dunes). Between Ls = 248° in Mars Year 33 and Ls = 51° in Mars Year 37, over ∼3.5 Mars years and 2,300 sols, the rover's Navigation Cameras took 1,260 dedicated image sequences to search for dust lifting. Approximately 42.7% of all sequences, and 9.5% of the total images have shown active dust lifting, both dust devils and linear/straight‐line wind stress dust lifting. 79% of dust lifting events are classified as dust devils, while ∼16% are linear wind stress dust lifting and the remainder are of an indeterminate type. We analyze this large catalog of dust lifting events to provide ground truth on theoretical and model expectations of dust lifting and show that dust lifting in Gale Crater occurs throughout the Martian year, is strongly peaked in frequency near solar noon (even after accounting for observational biases), and that dust lifting shows an affinity for sand‐covered surfaces which highlights the importance of saltating sand grains for Martian dust lifting in both dust devils and wind stress forced lifting.
Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability
Authors: Wootton Olivia , Shadrin Alexey A. , Mohn Christine , Susser Ezra , Ramesar Raj , Gur Ruben C. , Andreassen Ole A. , Stein Dan J. , Dalvie Shareefa 
Published: October 2023

AbstractReaction time variability (RTV), reflecting fluctuations in response time on cognitive tasks, has been proposed as an endophenotype for many neuropsychiatric disorders. There have been no large-scale genome-wide association studies (GWAS) of RTV and little is known about its genetic underpinnings. Here, we used data from the UK Biobank to conduct a GWAS of RTV in participants of white British ancestry (n = 404,302) as well as a trans-ancestry GWAS meta-analysis (n = 44,873) to assess replication. We found 161 genome-wide significant single nucleotide polymorphisms (SNPs) distributed across 7 genomic loci in our discovery GWAS. Functional annotation of the variants implicated genes involved in synaptic function and neural development. The SNP-based heritability (h2SNP) estimate for RTV was 3%. We investigated genetic correlations between RTV and selected neuropsychological traits using linkage disequilibrium score regression, and found significant correlations with several traits, including a positive correlation with mean reaction time and schizophrenia. Despite the high genetic correlation between RTV and mean reaction time, we demonstrate distinctions in the genetic underpinnings of these traits. Lastly, we assessed the predictive ability of a polygenic score (PGS) for RTV, calculated using PRSice and PRS-CS, and found that the RTV-PGS significantly predicted RTV in independent cohorts, but that the generalisability to other ancestry groups was poor. These results identify genetic underpinnings of RTV, and support the use of RTV as an endophenotype for neurological and psychiatric disorders.
Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer
Authors: Wang Yue , Han Jingyi , Wang Dongdong , Cai Menghua , Xu Yi , Hu Yu , Chen Hui , He Wei , Zhang Jianmin 
Published: October 2023

Abstractγδ T cells have the unique ability to detect a wide range of tumors with low mutation burdens, making them attractive candidates for CAR-T-cell therapy. Unlike αβ T cells and other immune cells, γδ T cells are superior in MHC non-restriction, selective cell recruitment, and rapid activation. However, clinical trials have shown limited clinical benefits, and the adoptive transplantation of γδ T cells has often fallen short of expectations. We hypothesized that the limited effectiveness of γδ T cells in eradicating tumor cells may be attributed to the inhibitory tumor microenvironment induced by the suppressive PD-1/PD-L1 axis. Herein, we constructed novel armored γδ T cells capable of secreting humanized anti-PD-1 antibodies, referred to as “Lv-PD1-γδ T cells. Lv-PD1-γδ T cells showed improved proliferation and enhanced cytotoxicity against tumor cells, resulting in augmented therapeutic effects and survival benefits in ovarian tumor-bearing mice. These engineered cells demonstrated a prolonged in vivo survival of more than 29 days, without any potential for tumorigenicity in immunodeficient NOD/SCID/γ null mice. We also found that Lv-PD1-γδ T cells exhibited excellent tolerance and safety in humanized NOD/SCID/γ null mice. With attenuated or eliminated immunosuppression and maximized cytotoxicity efficacy by the local secretion of anti-PD1 antibodies in tumors, Lv-PD1-γδ T cells can serve as a promising “off-the-shelf” cell therapy against cancers.
E-cigarette side effects in otolaryngology: unveiling the vape mirage
Authors: Baniulyte Gabriele , Ali Kamran 
Published: October 2023

Abstract
Data sources
The following databases were searched for publications up to May 2020: Web of Science, EMBASE, CENTRAL, Medline and CINAHL. Additionally, previously published reviews were hand searched.

Study selection
Clinical studies conducted in English language were considered, encompassing cohorts of more than four vaping individuals who have encountered inadvertent side effects. Both adult and paediatric populations were included. In vitro, animal studies and systematic or literature reviews were excluded from the analysis.

Data extraction and synthesis
Two independent reviewers screened 1125 studies following deduplication. Two-hundred and eight full-text studies were assessed for eligibility.

Results
Thirty-two studies met the inclusion criteria. Diverse study designs were included, comprising of cross-sectional, randomised controlled trials, case-control studies, cohort studies, case series investigations and non-randomised trials. Of note, four studies focused on paediatric patients. Most reported side effects were cough, throat and mouth irritation and intra-oral lesions.

Conclusions
While the direct side effects of e-cigarettes are well-documented, the long-term effects remain uncertain.