bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Time for ChitChat? Artificial intelligence Chatbots as a tool to identify research priorities in hip and knee arthroplasty.
Authors: Ridha Ali , Ahmed Imran , Raj Siddarth , Syed Farhan , Wasim Abdus , Smith Toby , Khatri Chetan 
Published: October 2023

Abstract
Background: Artificial intelligence (AI) Chatbots, such as ChatGPT3, have gained attention in medical and non-medical domains. Their ability to identify research gaps in orthopaedics is yet to be tested.
Aims: This study aimed to assess the application of three AI Chatbots to identify research questions in hip and knee arthroplasty in comparison to an existing research prioritisation consensus method.
Methods: Three Chatbots, ChatGPT3, Bing and Bard were prompted to identify research questions in hip and knee arthroplasty. Two authors independently compared the responses to the 21 research priorities for hip and knee arthroplasty established by the James Lind Alliance (JLA). Any discrepancies were discussed with senior authors.
Results: ChatGPT3 successfully identified to 15 (71%) priorities. Bard, nine (42%) priorities, while Bing identified eight (38%). The Chatbots identified further questions that were not stated in the JLA exercise (ChatGPT3: 12 questions; Bard: 14 questions; Bing: 11 questions). All three Chatbots failed to identify five (24%) of the JLA research priorities.
Conclusions: This study reports the first evidence of the potential adoption of AI Chatbots to identify research questions in hip and knee arthroplasty. This may potentially represent a valuable adjunct in improving efficiency of research prioritisation exercises.
Inhibition of glucose uptake increase serial-killing capacity of Natural Killer cells
Authors: Picard Lea Katharina , Niemann Jens Alexander , Littwitz-Salomon Elisabeth , Waldmann Herbert , Watzl Carsten 
Published: October 2023

Abstract
Tumor cells rely heavily on glycolysis to meet their high metabolic demands. While this results in nutrient deprivation within the tumor microenvironment and has negative effects on infiltrating immune cells such as Natural Killer (NK) cells, it also creates a potential target for cancer therapies. Here we use Glupin, an inhibitor of glucose transporters, to study the effect of limited glucose uptake on NK cells and their anti-tumor functions. Glupin treatment effectively inhibited glucose uptake and restricted glycolysis in NK cells. However, acute treatment had no negative effect on NK cell cytotoxicity or cytokine production. Long-term restriction of glucose uptake by Glupin treatment only delayed NK cell proliferation as they could switch to glutaminolysis as alternative energy source. While IFN-g production was partially impaired, long-term Glupin treatment had no negative effect on degranulation. Interestingly, the serial killing activity of NK cells was even enhanced, possibly due to changes in NAD metabolism. This demonstrates that NK cell cytotoxicity is remarkably robust and insensitive to metabolic disturbances and makes cellular metabolism an attractive target for immune-mediated tumor therapies.
Predictive Characteristics of Childhood emergency injury presentations in non-urban Victoria, Australia.
Authors: Peck Blake , Terry Daniel , Kloot Kate 
Published: October 2023

Abstract
Background
Injury is the leading cause of death and disability amongst those between 0–16 years of age. Routinely associated with a social gradient of health, childhood injury is reportedly higher in rural and regional areas. The Rural Acute Hospital Data Register (RAHDaR), which includes previously non-reported data, provides a more accurate understanding of injury emergency presentation events and the factors associated with these presentations.
Methods
A retrospective cross-sectional study collected de-identified emergency injury presentation data from nine health services in regional Victoria for children aged 0–14 years between 2017 and 2022. Demographic and presentation data were collated along with government datasets. Emergency injury presentation incidence rates and predictor variables were analysed using hierarchical multiple regression. Significance was determined at p < 0.05.
Results
Among the 15884 emergency injury presentations, 35.2% (n = 5,597) occurred at health services who did not previously report data. This increase in our understanding of emergency injury presentations demonstrates a rate of 141.63 presentations per 1000 children per year. Key factors such as age, gender, local attendance rates of free three-and-a-half year final stage child health assessment and pre-school, an increasing number of GPs per head of population and Index of Education and Occupation were associated with emergency injury presentation events across gender, while socioeconomic status was not predictive. Interestingly local rates of attendance at free three-and-a-half year final stage child health assessment and attending pre-school were specifically predictive among the 0–4 age group.
Conclusions
Although some findings are consistent with current research, the study high- lights previously unrecognized specific factors that are predictive of injury among 0-4-year-old children that require deeper investigation. These findings provide more accurate insights for healthcare workers and policymakers as they seek to support people with injury and accurately address health inequities.
Evaluating Patient Experience to Improve Care in a Specialist Antenatal Clinic for Pregnancy After Loss
Authors: Tamber Kajal K , Barron Rebecca , Tomlinson Emma , Heazell Alexander EP 
Published: October 2023

Abstract
In the United Kingdom, roughly 1 in 250 babies are stillborn each year. Most women who experience stillbirth become pregnant again – 80% within a year of loss. Presently, obstetric-led care is recommended; though there is a growing body of evidence to support provision of a specialist service. The Rainbow Clinic is a specialist antenatal service providing care for pregnancies after loss incorporating clinical and psychological care. This study aimed to assess patient experience at the Rainbow Clinic and identify areas for clinical improvement. A 13-item questionnaire was distributed to pregnant women who attended the Rainbow Clinics at the Oxford Road and Wythenshawe sites of Saint Mary’s Hospital, Manchester between July 2016 and June 2021. Descriptive statistics and unpaired t-test were used for quantitative data and summative content analysis for qualitative data. Four-hundred and fifty-six women completed the questionnaire. The mean patient experience score per quarter was stable with an average of 21.1 (± 3.0) for the five years, with a maximum attainable score of 25. The COVID-19 pandemic had no effect on patient experience at the Rainbow Clinic (pre-pandemic v during-pandemic: mean 21.2 v 21.3; p = 0.75). Free-text responses demonstrated women felt positively about the antenatal care received. Identified areas for improvement included “more awareness of the [Rainbow] sticker” to ensure women with previous loss are identified; increased publicity of the Rainbow Clinic services; developing more clinics at different locations to improve accessibility; and continuing specialist input into intrapartum care. Specialist antenatal care provided by the Rainbow Clinic was rated as of a high standard. Potential future improvements include sticker alterations (or other mechanisms to identify women who have experienced a previous loss) and develop increased awareness of the clinic in other institutions.
Ultrafast underwater self-healing piezo-ionic elastomer via dynamic hydrophobic-hydrolytic domains
Authors: Kim Do Hwan , Kong Zhengyang , Boahen Elvis K. , Kim Dong Jun , Li Fenglong , Kim Joo Sung , Kweon Hyukmin , Kim So Young , Choi Hanbin , Zhu Jin , Ying Wu Bin 
Published: October 2023

Abstract
The development of advanced materials capable of autonomous self-healing and mechanical stimulus sensing in aquatic environments holds great promise for applications in underwater soft electronics, underwater robotics, and water-resistant human-machine interfaces. However, achieving superior autonomous self-healing properties and effective sensing simultaneously in an aquatic environment is rarely feasible. Here, we present an ultrafast underwater molecularly engineered self-healing piezo-ionic elastomer (MESHPIE) inspired by the cephalopod’s suckers, which possess self-healing properties and mechanosensitive ion channels. Through strategic engineering of hydrophobic C–F groups, hydrolytic boronate ester bonds, and ions, the material achieves outstanding self-healing efficiencies, with speeds of 94.5% (9.1 µm/min) in air and 89.6% (13.3 µm/min) underwater, coupled with remarkable pressure sensitivity (18.1 kPa–1) for sensing performance. Furthermore, integration of this mechanosensitive device into an underwater submarine for signal transmission and LED modulation demonstrates its potential for underwater robotics and smarter human-machine interactions.
Coordination of Head Node Selection Based Energy Efficient Relay Node Routing Protocol for Manet
Authors: Krishnamoorthy Thamizhmaran , Arputham Charles 
Published: October 2023

Abstract
Emerging article we will discussed in one types of cluster based infrastructure less network called Mobile Ad hoc Networks (MANET), because most of the young researcher sincerely worked in this area. MANET is communicated through collections in many of active in-depended mobile nodes that self configured dynamic distributed network affects for many challenging issue such as routing, energy, security, packet drop, packet loss, time delay, mobility and bandwidth etc. In this work proposed cluster head based energy efficient design called Cluster Head selection based energy efficient Relay Node Selection Randomly (CH-RNSR) protocol based on reactive routing protocol they work path selection routing between source and destination via active intermediate nodes for mobile network specially developed to aware head node energy issue compare to existing relay node selection routing protocol, due to increasing remaining energy automatically improve network lifetime and delivery ratio simulated via NS2, the following research used all conditions.
Survey of Awareness and Beliefs about Cancer (ABC) in Tehran Province, Iran
Authors: Akbari Paria , Nemati Saeed , Nahvijou Azin , Bolourinejad Paria , Forbes Lindsay , Zendehdel Kazem 
Published: October 2023

Abstract

Introduction
Knowledge, attitudes and practices are important measures for planning and evaluating cancer control programs. Little is known about these in Iran.
Methods
We conducted a population-based interview survey of adults aged 30–70 using the Farsi version of the Awareness and Beliefs about Cancer questionnaire in the capital province of Tehran, Iran, in 2019. We calculated weighted estimates of levels of cancer knowledge, attitudes and practices to allow for different selection probabilities and for nonresponse. We used multivariate logistic regression to understand demographic factors associated with bowel, cervix, and breast screening practices.
Results
We interviewed 736 men and 744 women. The mean number of recalled cancer warning signs was less than one; 57.7% could not recall any cancer warning signs. On average, participants recognized 5.6 out of 11 early cancer warning signs and 8.8 of 13 cancer risk factors. Most (82.7%) did not know that HPV infection was a cancer risk factor. Approximately, half had negative attitudes towards cancer treatment, but over 80% had positive attitudes towards the effectiveness of screening for improving survival. Colorectal, breast, and cervical screening rates were 24%, 42%, and 49%, respectively. Higher socioeconomic status increased the odds of screening for cancer. Women aged 60–70 were less likely to report taking up breast and cervical screening than younger women.
Discussion
The Iranian population has poor awareness and negative attitudes about cancer, and participation in screening programs is low. Public awareness and early detection of cancer should be promoted in Iran.
Corrosion of Q235 carbon steel induced by sulfate-reducing bacteria in groundwater: corrosion behavior, corrosion product and microbial community structure
Authors: Hua Wenxin , Sun Rui , Wang Xiaoyan , Zhang Yunyun , Li Jiaxing , Qiu Ri , Gao Yu 
Published: October 2023

Abstract
Microbiologically influenced corrosion (MIC) is one of the reasons leading to the service failure of pipelines buried in the soil. To investigate the effect of sulfate-reducing bacteria (SRB) on the corrosion behavior of Q235 carbon steel in groundwater, a hanging plate test was carried out and the SRB was characterized by electrochemical methods, surface analysis, and biological analysis. In addition, a group of blank experiments was used as a control. The results showed that SRB continued to grow and reproduce in groundwater without lacking a carbon source for 14d to maintain life activities. The community structure has changed after corrosion, and the dominant species of SRB has changed from Desulfovibrio to Desulfosporosinus. During the whole growth cycle, the electrochemical results demonstrated that the impedance of the carbon steel surface forming a biofilm was 1 order of magnitude higher than that of other periods, and the formed ferrous sulfide layer also hindered the occurrence of corrosion. In comparison to the condition without SRB, the inclusion of SRB results in reduced weight loss. The average weight loss with SRB is 0.01389 g, whereas the average weight loss without SRB is 0.03956 g. However, the 3D topography indicated that the surface of carbon steel was more uneven and pits were increased with SRB. Altogether these results implied that the growth of SRB makes the corrosion process of Q235 carbon steel more complicated.
Effect of Growth Hormone in Patients with Moderate to Severe Intrauterine Adhesions
Authors: Guo Luwei , Zhang Kunjie , Li Yongfang , Yang Xin , Lin Jiayu 
Published: October 2023

Abstract
Purpose

Intrauterine adhesion (IUA) is one of the obstetrics and gynecology diseases that affect female fertility. The treatment of hysteroscopic adhesiolysis in combination with postoperative hormone therapy has not gained satisfactory effects yet. Since growth hormone (GH) promotes endometrial growth, we wanted to explore the therapeutic effect of GH on patients with moderate to severe IUA clinically.

Methods

We retrospectively analyzed the data of 18 IUA patients, who underwent transcervical resection of adhesion (TCRA) procedure followed by estrogen-progestin sequential therapy and GH administration, with 16 patients who did not receive GH therapy. Patients’ endometria were reexamined and their menstrual recovery was followed up.

Results

There were no statistically significant differences between the two groups in basic characteristics, preoperative American Fertility Society (AFS) score, endometrial thickness difference, and menstrual recovery. On average, patients treated with GH showed a more pronounced increase in endometrial thickness change and a better menstrual pattern, although under the basis of a slightly higher preoperative AFS.

Conclusion

It appeared GH did no difference in moderate to severe IUA. More data are worth accumulating to determine the role of GH in IUA treatment.
Parchmentization process for low cost novel separator for whey protein treatment in microbial fuel cell
Authors: Abdulwahhab Maha A. Allawi , Najim Sarmad talib 
Published: October 2023

Abstract
This study compared the performance of microbial fuel cells (MFCs) using parchment paper as a separator to a CMI7000 proton exchange membrane. The MFCs were operated in two chambers with whey solution as the substrate. Parameters such as COD removal, internal resistance, power density, current density, and Columbic efficiency ratio (CE) were evaluated. The CMI7000 membrane exhibited the highest COD removal at 92%, while the parchment paper achieved removal percentages ranging from 72–91%. The internal resistance was lower for the parchment paper separator for the first run, the internal resistances were 68 and 84 for parchment paper and CMI7000, respectively. The maximum energy densities were 219 mW/m (5.74 mA/m) and 421 mW/m (8.24 mA/m) for parchment paper and CMI7000 membrane, respectively. The CE values for parchment paper were 36.32 and 33.5, while for the CMI7000 membrane, they were 42.73 and 32.0, for the two runs. Overall, the study demonstrated that the parchment paper separator performed reasonably well in terms of COD removal, internal resistance, energy density, and Columbic efficiency ratio compared to the CMI7000 membrane in microbial fuel cells.
Effector Proteins of Funneliformis mosseae: Unravelling Plant-Fungal Interactions through Reference-Based Transcriptome Analysis, In vitro Validation, and Protein‒protein Docking Studies
Authors: Singh Pushplata Prasad , Srivast Divya , Vasistha Pratima , Shukla Sadhana , Johny Leena 
Published: October 2023

Abstract

Background
Arbuscular mycorrhizal (AM) fungi form a highly adaptable and versatile group of fungi found in natural and man-managed ecosystems. Cell signaling molecules are important in establishing symbiosis between host plants and AM fungi. Recent studies have illustrated that effector proteins produced by AM fungi influence host-plant defense responses during the establishment of interactions between host plants and AM fungi. Fungal effectors are secretory proteins capable of modifying host cells, suppressing host defense and promoting infection by fungi to derive nutrients from the host. The effectors are delivered to the host via diverse mechanisms and at different stages based on environmental triggers.
Results
Here, we carried out transcriptome sequencing of Funneliformis mosseae isolate BR221 and identified the expressed gene repertoires. The study emphasized the annotation of putative effector proteins and investigation of the crucial effector proteins that interact with the candidate host targets involved in immunomodulation and facilitation of colonization in roots. A total of 120 effector proteins were identified in F. mosseae isolate BR221, of which 26 were found to be common to previously reported species of AM fungi. In silico prediction using a pathogen‒host interaction database suggested that four effectors could be crucial in establishing AM fungi-host interactions. Protein‒protein in silico interactions between the selected effectors of F. mosseae isolate BR221 and known host-plant proteins previously reported to be important in mycorrhizal association emphasized the potential role of the four selected effectors of F. mosseae in AM fungus-host interactions. Real-time expression of these effectors in F. mosseae isolate BR221 was validated using qPCR experiments.
Conclusions
Through transcriptome analysis of Funneliformis mosseae isolate BR221, we identified key effector proteins central to AM fungi-host symbiosis, with four effectors underscored by in silico prediction and experimental validation as pivotal in mediating this crucial interaction.
Enhancing Air Quality: Investigating Training Room Environments in a Technical University's Sports Facilities
Authors: Melaniuk-Wolny Edyta , Widziewicz-Rzońca Kamila 
Published: October 2023

Abstract
Air quality analyses were conducted in sports facilities at the Silesian University of Technology in Poland, with a specific focus on training rooms occupied by students. The study aimed to assess the impact of indoor air quality (IAQ) on human health, taking into consideration various ventilation methods and the number of individuals exercising indoors. Air samples were collected from five training rooms within three sports facilities. The results indicate that outdoor air primarily influences air quality in sports facilities. Internal factors, such as the number of students, floor surfaces, and mattresses, influenced pollutant concentrations (CO2 and PM2.5). Overall, CO2 levels remained within safe limits, but fluctuations occurred due to physical activity, reaching as high as 1859.7 ppm. The average median concentration of indoor PM2.5 was 16.7 µg/m³, while outdoor levels averaged 12.2 µg/m³. A correlation between indoor and outdoor PM2.5 pollution underscores the importance of using air purifiers to enhance air quality in sports halls.
Value-based pre-operative assessment in a large academic hospital
Authors: Cecconi Maurizio , Goretti Giulia , Pradella Andrea , Meroni Patrizia , Pisarra Martina , Torzilli Guido , Montorsi Marco , Spinelli Antonino , Zerbi Alessandro , Castoro Carlo , Casale Paolo , Civilini Efrem , Quagliuolo Vittorio , Klinger Marco , Spriano Giuseppe , Vitobello Domenico , Maradei Leonardo , Reimers Bernhard , Piccioni Federico , Martucci Maria Rosaria , Stomeo Niccolò , Vanni Elena , Babbini Marco , Monzani Roberta , Capogreco Maria Rosaria , Lagioia Michele , Greco Massimiliano 
Published: October 2023

Abstract
Background:
Value-based healthcare (VBHC) aims to improve healthcare by increasing value outcomes. Our study evaluated whether personalised preoperative evaluation based on VBHC principles improves care and outcomes, thus reducing costs.
Methods: We conducted a quality improvement before-and-after study to determine the impact of VBHC on preoperative evaluation clinics in Humanitas Research Hospital.
The intervention was the implementation of a VBHC-tailored risk matrix during the postintervention phase (year 2021), and the results were compared with those of the preinterventionphase (2019).
The primary study outcome was the difference in the number of preoperative tests and visits per patient at baseline and after the intervention.
Results: A total of 9,722 patients were included: 5,242 for 2019 and 4,480 for 2021. The median age of the population was 63 (IQR: 51-72), 23% of patients were ASA 3 and 4, and 26.8% (2,955 cases) were day surgery cases. We found a considerable decrease in the number of preoperative tests ordered for each patient after the intervention [6.2 (2.5) vs 5.3 (2.6) tests, p <0.001]. The number of preoperative chest X-ray, electrocardiogram, and cardiac exams decreased significantly. The length of the preoperative course was significantly shorter after the intervention [373 (136) vs 290 (157) minutes, p<0.001]. Cost analysis demonstrated a significant reduction in costs, while there was no difference in clinical outcomes.
Conclusions: We demonstrated the feasibility, safety, and cost-effectiveness of a personalized approach to preoperative evaluation. The implementation of VBHC notably enhanced patient care value, as evidenced by decreased patient time in preoperative evaluation and by a reduction in unnecessary preoperative tests.