bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on Adsorption Properties of Cellulose Based Hydrogels
Authors: Li Haihua , Gao Yuhua , Zheng Yuxuan 
Published: October 2023

Abstract
The hydrogel prepared from biomass can be used as the absorbent gel and the adsorbent for heavy metal ions. Cellulose based hydrogel CMC/P(AM-AMPS) was synthesized with sodium carboxymethyl cellulose (CMC) as raw material, acrylamide (AM) and 2-acrylamide-2-methylpropane sulfonic acid (AMPS) as grafting monomer through grafting and crosslinking reaction. The test results showed that the hydrogel had strong adsorption properties, and the swelling rate could reach 198.20 g/g in 2h; When the initial concentration of Cu2+ was 10 mg/L and the dosage of CMC/P(AM-AMPS) was 400 mg/L, the removal rate of Cu2+ could reach 91.2%, and the equilibrium adsorption amount could reach 22.80 mg/g.
Experimental and Theoretical Studies on the Self-assembled Nano-structure of Nonionic Surfactant/ionic Liquid Hybrid Systems
Authors: Zhu Jingjing , Hua Er , Harada Masafumi 
Published: October 2023

Abstract
The self-assembled structure of various Brij series nonionic surfactants (such as Brij-30, Brij-52, Brij-56, Brij-58, Brij-35, and Brij-700) hybridized with room-temperature ionic liquids (RTILs) was studied using small-angle X-ray scattering (SAXS) measurements and DFT calculations. The detailed characterization of the obtained self-assembled structure in nonionic surfactant/RTILs hybrid system was carried out using the combination of SAXS and DFT calculations. The SAXS result indicates that the alkyl chain length dependence on the spatial correlation corresponds to the interference peak angle. The addition of Brij surfactant to the [BMIm][PF6] results in a drastic change in the interference peak position. The DFT calculation result shows that a weak hydrogen bonding was formed between the −CH, −F of RTILs ([BMIm][PF6] and [OMIm][PF6]) and the polar site −OH, −O − of surfactants (Brij-30 and Brij-56). When the mixing molar ratio of ILs/Brij is 1:1, the absolute value of interaction energy (ΔE
0
BSSE) is 8.10-1.43 and 4.22-0.90 kcal·mol-1 for ILs/Brij-30 and ILs/Brij-56, respectively. Meanwhile, in the case of the ILs/Brij molar ratio equal to 2:1, ΔE
0
BSSE is 19.14-1.79 and 12.39-1.45 kcal·mol-1, respectively. It suggests that the stability of ILs/Brij hybridized system is higher for ILs/Brij-30 than for ILs/Brij56, and it has an increasing tendency to some extent with an increase of the molar fraction of ILs.
Development and application of the 2×350kN dual parallel excitation horizontal vibration test system
Authors: Zhiqiang Shen , Xinming Li , Jungang Zhang , Guiqian Fang , Chuang Liu , yicun Xie , qi Xin 
Published: October 2023

Abstract
Vibration test is an important method to test the vibration environment during the launch and flight of spacecraft. With the development of China’s space industry, large spacecraft weighing more than 10 tons and diameter greater than 3 m are becoming more and more common. Key capabilities such as load bearing, table size, rated thrust and overturning moment of the original vibration test equipment can not meet the needs of large spacecraft development. Therefore, this paper develops a set of 2×350kN dual parallel excitation horizontal vibration test system which can carry out horizontal vibration test of large spacecraft. This paper introduces the structure and design method of the system, and analyzes the test results of the system. The technical indexes of the system all meet the design requirements. The system has been successfully applied to the vibration test simulation of large spacecraft such as the core module of the space station, which provides a better evaluation method for the ground test of large spacecraft in China.
Development of methane leakage telemetry system based on tunable diode laser absorption spectroscopy
Authors: Ma Rong , Pan Fu-qian , Wang Ting , Hu Bing , Liang Xiao-yu , Yu Yue 
Published: October 2023

Abstract
A methane telemetry system based on Tunable Diode Laser Absorption Spectroscopy (TDLAS) is proposed for the long-range, high-precision, and real-time measurement of methane concentration in coal mine safety production. The output wavelength of the tunable semiconductor laser is controlled to scan at 1654nm (6045.94cm−1) of the methane absorption spectrum. The harmonic signal is obtained by digital phase locking technique, and the effect of light intensity variation on the system measurement results is eliminated by 2f/1f signal processing technique. Through calibration experiment and measurement error analysis, the measurement error of the system is less than 10%, which proves that the device has the advantages of high accuracy.
Single breath counting technique to assess pulmonary function: a systematic review and meta-analysis
Authors: Delmondes Glívia Maria Barros , Couto Nathália Ferreira Santos , Correia Junior Murilo Gominho Antunes , Bonifácio Amanda Bezerra da Silva , Freitas Dias Ricardo de , Bezerra Jorge , Santos Marcos André de Moura , Gomes de Barros Mauro Virgílio , Costa Emília Chagas , Correia Junior Marco Aurélio de Valois 
Published: October 2023

Abstract
Pulmonary function is usually assessed by measuring Vital Capacity (VC) using equipment such as a spirometer or ventilometer, but these are not always available to the population, as they are relatively expensive tests, difficult to transport and require trained professionals. However, the single breath counting technique (SBCT) appears as a possible alternative to respiratory function tests, to help in the pathophysiological understanding of lung diseases. The objective is to verify the applicability of the SBCT as a parameter for evaluating VC. This is a systematic review registered in the International Prospective Register of Systematic Reviews (CRD42023383706) and used for PubMed®, Scientific Electronic Library Online, LILACS, EMBASE, and Web of Science databases of articles published until January 2023. Methodological quality regarding the risk of bias was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 and National Institutes of Health tools. Eleven of a total of 574 studies were included, of these, nine showed a correlation between VC and SBCT (weak in healthy, moderate in neuromuscular and strong in hospitalized patients). One study of hospitalized patients accurately identified a count value of 21 for a VC of 20 ml kg−1 (Sensitivity = 94% and Specificity = 77%), and another estimated a count lower than 41 for a VC below 80% of predicted in patients with neuromuscular dystrophy (Sensitivity = 89% and Specificity = 62%), and another showed good intra and inter-examiner reproducibility in young, adult, and elderly populations. A meta-analysis of three studies showed a moderate correlation in subjects with neuromuscular diseases (r = 0.62, 95% CI = 0.52–0.71, p < 0.01). A high risk of bias was identified regarding the justification of the sample size and blinding of the evaluators. SBCT has been presented as an alternative to assess VC in the absence of specific equipment. There is a clear relationship between SBCT and VC, especially in neuromuscular and hospitalized individuals. New validation studies conducted with greater control of potential bias risks are necessary.
Simulation study on the conversion between CT and CBCT dose quantities via the effective dose
Authors: Ketelhut Steffen , Kuhlmann Marie-Luise , Büermann Ludwig , Pirl Lukas , Borowski Markus 
Published: October 2023

Abstract
In recent years, cone-beam computed tomography (CBCT) has been used in many imaging tasks traditionally performed by computed tomography (CT). This has created challenges for dosimetry, as the dose quantities in CBCT and CT, i.e. the dose-area product (DAP) and dose-length product (DLP), are not mutually convertible. Convertibility would be desirable to compare doses in similar clinical studies performed using CT or CBCT and ultimately for the application of diagnostic reference levels (DRLs). In this work, the conversion of the DAP into the DLP and vice versa via the effective dose E is investigated with the aim of finding common diagnostic reference levels. The dose calculation was performed using Monte Carlo simulations for scan regions with imaging tasks, which can be carried out either with CT or CBCT scanners. Four regions in the head and four in the trunk were chosen. The calculations resulted in conversion coefficients

k
=

DAP

DLP

of 30(4) cm for the cranium, 22(4) cm for the facial bones, 24(2) cm for the paranasal sinuses, 18(2) cm for the cervical spine, 78(12) cm for the thorax, 85(13) cm for the upper abdomen, 57(6) cm for the lumbar spine and 70(12) cm for the pelvis.
A surjective summation operator with no Lipschitz right inverse
Authors: Laustsen Niels Jakob , Messerschmidt Miek , Wortel Marten 
Published: October 2023

We show that there exists a Banach space

X
X

which contains closed subspaces

Y
Y

and

Z
Z

with

Y
+
Z
=
X

Y+Z=X

such that the associated surjective summation operator

Σ
:
Y
×
Z
→
X

\Sigma \colon Y\times Z\to X

defined by

Σ
(
y
,
z
)
=
y
+
z

\Sigma (y,z)= y+z

for

y
∈
Y

y\in Y

and

z
∈
Z

z\in Z

has no Lipschitz right inverse.
ProsperousPlus: a one-stop and comprehensive platform for accurate protease-specific substrate cleavage prediction and machine-learning model construction
Authors: Li Fuyi , Wang Cong , Guo Xudong , Akutsu Tatsuya , Webb Geoffrey I , Coin Lachlan J M , Kurgan Lukasz , Song Jiangning 
Published: October 2023

AbstractProteases contribute to a broad spectrum of cellular functions. Given a relatively limited amount of experimental data, developing accurate sequence-based predictors of substrate cleavage sites facilitates a better understanding of protease functions and substrate specificity. While many protease-specific predictors of substrate cleavage sites were developed, these efforts are outpaced by the growth of the protease substrate cleavage data. In particular, since data for 100+ protease types are available and this number continues to grow, it becomes impractical to publish predictors for new protease types, and instead it might be better to provide a computational platform that helps users to quickly and efficiently build predictors that address their specific needs. To this end, we conceptualized, developed, tested and released a versatile bioinformatics platform, ProsperousPlus, that empowers users, even those with no programming or little bioinformatics background, to build fast and accurate predictors of substrate cleavage sites. ProsperousPlus facilitates the use of the rapidly accumulating substrate cleavage data to train, empirically assess and deploy predictive models for user-selected substrate types. Benchmarking tests on test datasets show that our platform produces predictors that on average exceed the predictive performance of current state-of-the-art approaches. ProsperousPlus is available as a webserver and a stand-alone software package at http://prosperousplus.unimelb-biotools.cloud.edu.au/.
Quantum annealing-based clustering of single cell RNA-seq data
Authors: Kubacki Michal , Niranjan Mahesan 
Published: October 2023

Abstract
Cluster analysis is a crucial stage in the analysis and interpretation of single-cell gene expression (scRNA-seq) data. It is an inherently ill-posed problem whose solutions depend heavily on hyper-parameter and algorithmic choice. The popular approach of K-means clustering, for example, depends heavily on the choice of K and the convergence of the expectation-maximization algorithm to local minima of the objective. Exhaustive search of the space for multiple good quality solutions is known to be a complex problem. Here, we show that quantum computing offers a solution to exploring the cost function of clustering by quantum annealing, implemented on a quantum computing facility offered by D-Wave [1]. Out formulation extracts minimum vertex cover of an affinity graph to sub-sample the cell population and quantum annealing to optimise the cost function. A distribution of low-energy solutions can thus be extracted, offering alternate hypotheses about how genes group together in their space of expressions.
Incidence, mortality and survival of Merkel cell carcinoma: a systematic review of population-based studies
Authors: Mohsen Samiha T , Price Emma L , Chan An-Wen , Hanna Timothy P , Limacher James J , Nessim Carolyn , Shiers Jessica E , Tron Victor , Wright Frances C , Drucker Aaron M 
Published: October 2023

Abstract

Background
Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer that most commonly occurs in ultraviolet-exposed body sites. The epidemiology of MCC in different geographies and populations is not well characterized.

Objectives
The objective of this systematic review is to summarize evidence on the incidence, mortality and survival rates of MCC from population-based studies.

Methods
We searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from database inception to 6 June 2023. No geographic, age or date exclusions were applied. We included population-based studies of MCC that reported the incidence, survival or mortality rate, and also considered systematic reviews. A data-charting form was created and validated to identify variables to extract. Two reviewers then independently charted the data for each included study with patient characteristics, and estimates of incidence rate, mortality rate, and survival rate and assessed the quality of included studies using the Joanna Briggs Institute Checklist for Prevalence studies, Newcastle–Ottawa Scale and Assessment of Multiple Systematic Reviews. We abstracted age-, sex-, stage- and race-stratified outcomes, and synthesized comparisons between strata narratively and using vote counting. We assessed the certainty of evidence for those comparisons using the Grading of Recommendations, Assessments, Developments and Evaluations framework.

Results
We identified 11 472 citations, of which 52 studies from 24 countries met our inclusion criteria. Stage I and the head and neck were the most frequently reported stage and location at diagnosis. The incidence of MCC is increasing over time (high certainty), with the highest reported incidences reported in southern hemisphere countries [Australia (2.5 per 100 000); New Zealand (0.96 per 100 000) (high certainty)]. Male patients generally had higher incidence rates compared with female patients (high certainty), although there were some variations over time periods. Survival rates varied, with lower survival and/or higher mortality associated with male sex (moderate certainty), higher stage at diagnosis (moderate-to-high certainty), older age (moderate certainty), and immunosuppression (low-to-moderate certainty).

Conclusions
MCC is increasing in incidence and may increase further given the ageing population of many countries. The prognosis of MCC is poor, particularly for male patients, those who are immunosuppressed, and patients diagnosed at higher stages or at an older age.
Demographics, diagnostics, treatment, and outcomes of patients presenting with acute groin hernia: 15-year multicentre retrospective cohort study
Authors: Brown Leo R , Clyde Danielle R , Li Lucy Q , Swan Rebecca , McLean Ross C , Damaskos Dimitrios 
Published: October 2023

Abstract

Background
Groin hernias commonly present acutely in high-risk populations and can be challenging to manage. This retrospective, observational study aimed to report on patient demographics and outcomes, following acute admissions with a groin hernia, in relation to contemporary investigative and management practices.

Methods
Adult (≥18 years old) patients who presented acutely with a groin hernia to nine National Health Service trusts in the north of England between 2002 and 2016 were included. Data were collected regarding patient demographics, radiological investigations, and operative intervention. The primary outcome of interest was 30-day inpatient mortality rate.

Results
Overall, 6165 patients with acute groin hernia were included (4698 inguinal and 1467 femoral hernias). There was a male preponderance (72.5 per cent) with median age of 73 years (interquartile range (i.q.r.) 58–82). The burden of patient co-morbidity increased over the study period (P &lt; 0.001). Operative repair was performed in 2258 (55.1 per cent) of patients with an inguinal and 1321 (90.1 per cent) of patients with a femoral hernia. Bowel resection was more commonly required for femoral hernias (14.7 per cent) than inguinal hernias (3.5 per cent, P &lt; 0.001) and in obstructed (14.6 versus 0.2 per cent, P &lt; 0.001) or strangulated (58.4 versus 4.5 per cent, P &lt; 0.001) hernias. The 30-day mortality rate was 3.1 per cent for the overall cohort and 3.9 per cent for those who underwent surgery. Bowel resection was associated with increased duration of hospital stay (P &lt; 0.001) and 30-day inpatient mortality rate (P &lt; 0.001). Following adjustment for confounding variables, advanced age, co-morbidity, obstruction, and strangulation were all associated with an increased 30-day mortality rate (all P &lt; 0.001).

Conclusion
Emergency hernia repair has high mortality rates. Advanced age and co-morbidity increase both duration of hospital stay and 30-day mortality rate.
Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Authors: Datta Dibyadeep , Perone Isabella , Morozov Yury M , Arellano Jon , Duque Alvaro , Rakic Pasko , van Dyck Christopher H , Arnsten Amy F T 
Published: October 2023

Abstract
Alzheimer’s disease cortical tau pathology initiates in the layer II cell clusters of entorhinal cortex, but it is not known why these specific neurons are so vulnerable. Aging macaques exhibit the same qualitative pattern of tau pathology as humans, including initial pathology in layer II entorhinal cortex clusters, and thus can inform etiological factors driving selective vulnerability. Macaque data have already shown that susceptible neurons in dorsolateral prefrontal cortex express a “signature of flexibility” near glutamate synapses on spines, where cAMP-PKA magnification of calcium signaling opens nearby potassium and hyperpolarization-activated cyclic nucleotide-gated channels to dynamically alter synapse strength. This process is regulated by PDE4A/D, mGluR3, and calbindin, to prevent toxic calcium actions; regulatory actions that are lost with age/inflammation, leading to tau phosphorylation. The current study examined whether a similar “signature of flexibility” expresses in layer II entorhinal cortex, investigating the localization of PDE4D, mGluR3, and HCN1 channels. Results showed a similar pattern to dorsolateral prefrontal cortex, with PDE4D and mGluR3 positioned to regulate internal calcium release near glutamate synapses, and HCN1 channels concentrated on spines. As layer II entorhinal cortex stellate cells do not express calbindin, even when young, they may be particularly vulnerable to magnified calcium actions and ensuing tau pathology.
Low-intensity ultrasound stimulation modulates cortical neurovascular coupling in an attention deficit hyperactivity disorder rat model
Authors: Wang Mengran , Wang Teng , Li Xin , Yuan Yi 
Published: October 2023

Abstract
Attention deficit hyperactivity disorder is accompanied by changes in cranial nerve function and cerebral blood flow (CBF). Low-intensity ultrasound stimulation can modulate brain neural activity in attention deficit hyperactivity disorder. However, to date, the modulatory effects of low-intensity ultrasound stimulation on CBF and neurovascular coupling in attention deficit hyperactivity disorder have not been reported. To address this question, Sprague-Dawley, Wistar-Kyoto, and spontaneously hypertensive (attention deficit hyperactivity disorder (ADHD) rat model) rats were divided into the control and low-intensity ultrasound stimulation (LIUS) groups. Cortical electrical stimulation was used to induce cortical excitability in different types of rats, and a penetrable laser speckle contrast imaging (LSCI) system and electrodes were used to evaluate the electrical stimulation-induced CBF, cortical excitability, and neurovascular coupling in free-moving rats. The CBF, cortical excitability, and neurovascular coupling (NVC) under cortical electrical stimulation in the attention deficit hyperactivity disorder rats were significantly different from those in the Sprague-Dawley and Wistar-Kyoto rats. We also found that low-intensity ultrasound stimulation significantly interfered with the cortical excitability and neurovascular coupling induced by cortical electrical stimulation in rats with attention deficit hyperactivity disorder. Our findings suggest that neurovascular coupling is a potential biomarker for attention deficit hyperactivity disorder. Furthermore, low-intensity ultrasound stimulation can improve abnormal brain function in attention deficit hyperactivity disorder and lay a research foundation for its application in the clinical treatment of attention deficit hyperactivity disorder.
Loneliness is related to smaller gray matter volumes in ACC and right VLPFC in people with major depression: a UK biobank study
Authors: He Zhenhong , Zheng Youcun , Ni Jingxuan , Huang Jin , Pang Qingqing , Chen Tongtong , Muhlert Nils , Elliott Rebecca 
Published: October 2023

Abstract
The anterior cingulate cortex (ACC) and right ventrolateral prefrontal cortex (VLPFC) are thought to have important roles in loneliness (feeling of social isolation/exclusion) experience or regulation and in the pathophysiology of their disturbance in major depressive disorder (MDD). However, the structural abnormalities of these regions and the correlates with loneliness in MDD across the healthy population have not fully been clarified. The study analyzed the link between loneliness and gray matter volumes (GMVs) in the ACC and right VLPFC among 1,005 patients with MDD and 7,247 healthy controls (HCs) using UK Biobank data. Significant reductions in GMV in the right VLPFC were found in MDD males compared to HCs. MDD males also showed a higher association between loneliness and reduced GMVs in the right VLPFC and bilateral ACC than HCs. No such associations were found in MDD females. The findings suggest that loneliness may influence brain structures crucial for emotion experience and regulation, particularly in middle-older aged men with MDD. This highlights the potential adverse effects of loneliness on brain structure in MDD and suggests that social engagement could have a positive impact.
The Spatial Economic Impact of Crime: Evidence from the Construction Sector in Italian Municipalities
Authors: Rizzo Leonzio , Ferraresi Massimiliano , Secomandi Riccardo 
Published: October 2023

Abstract
Literature has mainly focused on understanding whether organized crime impacts on economic growth, broadly intended. Yet, at the local level, little is known as to how crime may affect economic activities. Using a unique geo-localized dataset on Italian firms, we exploit the strengthening of policy enforcement against corruption to show that when municipalities where the city council is dissolved because of organized-crime infiltration, the construction sector suffers a 7% reduction in the value added of firms located in the same area where the council dissolution occurred. We also find that the effect is larger, the longer the commissioner is present in the municipal council. Taken together our findings suggest that the action of the commissioner depresses the economic activity in the construction sector of the area where the temporary-administered municipality is located, given that it blocks all those relationships with firms related with criminality. This calls for a contemporaneous intervention stimulating public procurements with ‘good’ firms. (JEL codes: K42, D73, R10 and H32)