bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do consumers make behavioural decisions on social commerce platforms? The interaction effect between behaviour visibility and social needs
Authors: Jia Yanli , Liu Libo , Lowry Paul Benjamin 
Published: February 2024

AbstractThe online phenomenon of social commerce (i.e., s‐commerce) platforms has emerged as a combination of online social networking and e‐commerce. On s‐commerce platforms, consumers can observe others' behavioural decisions and can distinguish those made by their friends from those made by their followees (i.e., the people a focal consumer follows but who do not follow that consumer back). Given this distinction, our study examines how consumers' behavioural decisions—regarding, for example, purchases, ratings, or “likes”—are made on s‐commerce platforms, with a focus on how they are influenced by prior decisions of friends and followees. Combining panel data from a large s‐commerce platform and two controlled experiments, we identify a strong normative social influence pattern in which consumers tend to follow others' prior decisions to gain social approval. Because the occurrence of normative social influence depends on both consumer behaviours with high public visibility and strong consumer needs to establish social ties, the unique information concerning behaviour visibility and consumers' social needs in the panel data allows us to identify normative social influence and to distinguish it from informational confounding mechanisms. Our panel data results show that on a friend network, where consumers' behavioural decisions are visible, females exhibit a greater tendency to follow others' prior decisions than males. We attribute this result to the stronger social needs of females. However, on a followee network, where behavioural decisions are invisible, these differences become less evident. Moreover, the two experiments demonstrate that making decision contexts private or activating social needs via a priming procedure can thwart (or even turn off) normative social influence. Our findings challenge prior research that identifies informational social influence as the predominant driver of conformity behaviours and thus have important implications for practice related to normative social influence, such as the development of techniques for satisfying consumers' different social needs depending on their gender or any other situational factors on s‐commerce platforms.
Composition‐dependent structural role of lead in aluminoborate and galloborate glasses: A solid‐state NMR study
Authors: Krishnamurthy Arun , Wren John E. C. , Michaelis Vladimir K. , Kroeker Scott 
Published: February 2024

AbstractInvestigations on binary lead‐bearing glass systems have shown that Pb2+ functions as a charge compensator at low concentrations and can participate in network formation at higher loadings. We use multinuclear magnetic resonance spectroscopy to investigate the mechanism underlying this dual‐role nature of Pb2+ in ternary lead‐borate glasses containing aluminum or gallium. 207Pb nuclear magnetic resonance (NMR) spectra—in conjunction with charge‐balance calculations, bond‐valence principles, and precedents from crystalline lead‐borates—are interpreted in terms of high‐ and low‐coordinate Pb2+ species, representing charge‐compensating “network modifier” sites and covalently‐bound “network forming” sites, respectively. Both high‐field 27Al and 71Ga magic‐angle spinning NMR spectra indicate the presence of substantial fractions of four, five, and six‐fold coordinated Al/Ga, reinforcing the isostructural nature of these elements. However, systematic differences in the boron speciation in Al‐ and Ga‐bearing glasses reveal that their size difference has a measurable effect on the short‐range structure in these glasses.
Genetic correlation estimates between calving ease in primiparous cows and economically important traits in Nellore cattle
Authors: Marinho de Negreiros Maria Paula , Amorim Sabrina Thaise , Lôbo Raysildo Barbosa , Brunes Ludmilla Costa , Magnabosco Claudio Ulhoa , Bergmann José Aurélio Garcia , Espigolan Rafael , Cravo Pereira Angelica Simone , Baldi Fernando 
Published: February 2024

AbstractThis study aimed to estimate (co)variance components and genetic parameters for calving ease (CE) and their genetic correlations with growth, reproductive, carcass, and feed efficiency traits in Nellore cattle. Phenotypes for CE are scored in two categories: normal calving and assisted calving. The traits considered were probability of precocious calving, age at first calving, stayability, adjusted scrotal circumference at 365 days of age, accumulated cow productivity, age at puberty of males, gestation length, birth weight, adjusted weights at 210 and 450 days of age, adult cow weight, frame score, hip height, rib eye area, subcutaneous backfat thickness, rump fat thickness, intramuscular fat percentage, residual feed intake and dry matter intake. The estimation of genetic parameters was performed using a two‐trait threshold‐linear animal model, except for CE, stayability, and probability of precocious calving, which were evaluated through a two‐trait threshold animal model. The direct (0.27) and maternal (0.19) heritability estimates for CE in heifers primiparous Nellore indicated that selecting for this trait is feasible. The selection to improve the female sexual precocity should consider CE during the selection and mating decisions to reduce calving problems. Genetic correlation estimates between CE and BW suggest that selecting low birth weight to reduce calving problems is not an appropriate strategy to improve calving ease in heifers Nellore. Therefore, adopting a multi‐trait selection model with CE and BW in the Nellore breed would reduce calving difficulties, particularly in sexually precocious heifers, without impairing the growth, reproductive, feed efficiency conversion, and carcass indicator traits.
ITGBL1 promotes anoikis resistance and metastasis in human gastric cancer via the AKT/FBLN2 axis
Authors: Shen Kanger , Xia Wei , Wang Kun , Li Juntao , Xu Wei , Liu Haoran , Yang Kexi , Zhu Jinghan , Wang Jiayu , Xi Qinhua , Shi Tongguo , Li Rui 
Published: February 2024

AbstractThe resistance to anoikis plays a critical role in the metastatic progression of various types of malignancies, including gastric cancer (GC). Nevertheless, the precise mechanism behind anoikis resistance is not fully understood. Here, our primary focus was to examine the function and underlying molecular mechanism of Integrin beta‐like 1 (ITGBL1) in the modulation of anoikis resistance and metastasis in GC. The findings of our investigation have demonstrated that the overexpression of ITGBL1 significantly augmented the resistance of GC cells to anoikis and promoted their metastatic potential, while knockdown of ITGBL1 had a suppressive effect on both cellular processes in vitro and in vivo. Mechanistically, we proved that ITGBL1 has a role in enhancing the resistance of GC cells to anoikis and promoting metastasis through the AKT/Fibulin‐2 (FBLN2) axis. The inhibition of AKT/FBLN2 signalling was able to reverse the impact of ITGBL1 on the resistance of GC cells to anoikis and their metastatic capability. Moreover, the expression levels of ITGBL1 were found to be significantly elevated in the cancerous tissues of patients diagnosed with GC, and there was a strong correlation observed between high expression levels of ITGBL1 and worse prognosis among individuals diagnosed with GC. Significantly, it was revealed that within our cohort of GC patients, individuals exhibiting elevated ITGBL1 expression and diminished FBLN2 expression experienced the worst prognosis. In conclusion, the findings of our study indicate that ITGBL1 may serve as a possible modulator of resistance to anoikis and the metastatic process in GC.
Identification of the shared genes in type 2 diabetes mellitus and osteoarthritis and the role of quercetin
Authors: Song Siyuan , Yu Jiangyi 
Published: February 2024

AbstractThis study investigated the underlying comorbidity mechanism between type 2 diabetes mellitus (T2DM) and osteoarthritis (OA), while also assessing the therapeutic potential of quercetin for early intervention and treatment of these two diseases. The shared genes were obtained through GEO2R, limma and weighted gene co‐expression network analysis (WGCNA), and validated using clinical databases and the area under the curves (ROC). Functional enrichment analysis was conducted to elucidate the underlying mechanisms of comorbidity between T2DM and OA. The infiltration of immune cells was analysed using the CIBERSORT algorithm in conjunction with ESTIMATE algorithm. Subsequently, transcriptional regulation analysis, potential chemical prediction, gene‐disease association, relationships between the shared genes and ferroptosis as well as immunity‐related genes were investigated along with molecular docking. We identified the 12 shared genes (EPHA3, RASIP1, PENK, LRRC17, CEBPB, EFEMP2, UBAP1, PPP1R15A, SPEN, MAFF, GADD45B and KLF4) across the four datasets. Our predictions suggested that targeting these shared genes could potentially serve as therapeutic interventions for both T2DM and OA. Specifically, they are involved in key signalling pathways such as p53, IL‐17, NF‐kB and MAPK signalling pathways. Furthermore, the regulation of ferroptosis and immunity appears to be interconnected in both diseases. Notably, in this context quercetin emerges as a promising drug candidate for treating T2DM and OA by specifically targeting the shared genes. We conducted a bioinformatics analysis to identify potential therapeutic targets, mechanisms and drugs for T2DM and OA, thereby offering novel insights into molecular therapy for these two diseases.
Morphology and motor behavior of endemic fishes in the upper reaches of the Yangtze River basin
Authors: Liu Shikang , Cao Chengyang , Xi Yuqian , Li Pengcheng , Chen Xuefeng , Xiao Lirong , Yao Weiwei 
Published: February 2024

AbstractDam construction alters the hydrodynamic conditions, consequently impacting the swimming behavior of fish. To explore the effect of flow hydrodynamics on fish swimming behavior, five endemic fish species in the upper Yangtze River basin were selected. Through high‐speed video visualization and computer analysis, these species' swimming patterns under different flow velocities (0.1–1.2 m/s) were investigated. The kinematic and morphological characteristics of the fish were presented. The principal component analysis was used to analyse the main factors influencing the swimming ability of fish and to determine the correlation coefficients among fish behavior indicators. Fish exhibited three different swimming patterns under different flow velocities. Low velocity (0.1–0.3 m/s) corresponds to free motion, middle velocity (0.4–0.7 m/s) corresponds to cruising motion, and high velocity corresponds to stress motion (0.8–1.2 m/s). The fish kinematic index curves were obtained, and four of five fish species showed two extreme points, which means the optimal and adverse swimming strategies can be determined. With the increase in flow velocity, the tail‐beat frequency showed an increasing trend, whereas the tail‐beat angle and amplitude showed a decreasing trend. Morphological and kinematic parameters were the two main indexes that affect the swimming ability of fish, which accounts for 41.9% and 26.9%, respectively.
A highly soluble form of rutin for instant resolution of mask‐wearing related disorders
Authors: De Tollenaere Morgane , Durduret Anaïs , Chapuis Emilie , Lambert Carole , Lemagnen Perrine , Tiguemounine Jean , Auriol Daniel , Scandolera Amandine , Reynaud Romain 
Published: February 2024

AbstractBackgroundThe COVID‐19 pandemic brought about a new normal, necessitating the use of personal protective equipment (PPE) like face shields, surgical masks, gloves, and goggles. However, prolonged mask‐wearing introduced skin‐related issues due to changes in the skin's microenvironment, including increased humidity and temperature, as well as pressure on the skin. These factors led to skin deformation, vascular issues, edema, and inflammation, resulting in discomfort and cosmetic concerns. Clinical reports quickly highlighted the consequences of long‐term mask use, including increased cases of “maskne” (mask‐related acne) or mask‐wearing related disorders such as rosacea flare‐ups, skin‐barrier defects, itching, erythema, redness, hyperpigmentation, and lichenification. Some of these issues, like inflammation, oxidative stress, and poor wound healing, could be directly linked to acne‐related disorders or skin hypoxia.AimTo address these problems, researchers turned to rutin, a well‐known flavonoid with antioxidant, vasoactive, and anti‐inflammatory properties. However, rutin's poor water solubility presented a challenge for cosmetic formulations. To overcome this limitation, a highly water‐soluble form of rutin was developed, making it suitable for use at higher concentrations.MethodsIn vitro and ex vivo tests were conducted, as well as an innovative clinical trial including volunteers wearing surgical masks for at least 2 h, to evaluate the biological activity of this soluble rutin on the main skin concerns associated with mask‐wearing (inflammation, oxidative stress, skin repair, hyperpigmentation, and skin redness).ResultsThe in vitro results showed that the active ingredient significantly reduced oxidative stress, improved wound healing, and reduced inflammation. In dark skin explants, the active ingredient significantly reduced melanin content, indicating its lightening activity. This effect was confirmed in the clinical study, where brown spots decreased significantly after 4 days of application. Moreover, measurements on volunteers demonstrated a decrease in skin redness and vascularization after the active ingredient application, indicating inflammation and erythema reduction. Volunteers reported improved skin comfort.ConclusionIn summary, the COVID‐19 pandemic led to various skin issues associated with mask‐wearing. A highly soluble form of rutin was developed, which effectively addressed these concerns by reducing inflammation, oxidative stress, and hyperpigmentation while promoting wound healing. This soluble rutin offers a promising solution for the rapid treatment of maskne‐related disorders and other skin problems caused by prolonged mask use.
Behavioral weight loss interventions for people with physical disabilities: A systematic review
Authors: Hossaini Jihad , Osmani Vanesa , Klug Stefanie J. 
Published: February 2024

SummaryAimThe aim of this study is to examine which interventions lead to clinically significant weight loss among people with physical disabilities.MethodsWe systematically searched three electronic databases (PubMed, Scopus, and CENTRAL) including studies until May 2022 to find randomized controlled trials on behavioral interventions and weight‐related outcomes in people with physical disabilities. Pharmacological or surgical interventions were excluded. Study quality was evaluated using the Cochrane Risk of Bias Tool. Interventions were grouped as dietary, physical activity, education/coaching, or multi‐component. Mean weight changes, standard deviations, confidence intervals, and effect sizes were extracted or calculated for assessment of the intervention effect.ResultsSixty studies involving 6,511 participants were included in the qualitative synthesis. Most studies (n = 32) included multi‐component interventions, incorporating dietary and physical activity components. Limited evidence suggests that extensive dietary interventions or long‐term multi‐component interventions might lead to a clinically relevant weight reduction of at least 5% for older individuals (age > 50) with mild‐to‐moderate mobility impairments.DiscussionDue to the high heterogeneity of studies and low study quality, it can be assumed that the range of applicability of the findings is questionable. Further research should examine younger age groups (i.e., children, adolescents, and adults under 40 years) and compare different settings such as schools, clinics, nursing homes, and assisted living facilities.
Frequency of the prominent transverse nasal root vein in children
Authors: López‐Carrera Igor , Lam Joseph M. , Torrelo Antonio 
Published: February 2024

AbstractBackgroundThe presence of a vascular, blue linear discoloration on the nasal root of infants and young children is a frequent incidental feature, rarely reported in the medical literature. It is related to the trajectory of the transverse nasal root vein (TNRV).ObjectiveTo study the frequency and clinical characteristics of the vascular discoloration of the nasal root in children.MethodsA prospective study was performed to address the presence or absence of vascular discoloration of the nasal root in all children under 6 years of age attending a pediatric dermatology clinic from November 2022 to November 2023. Data on age and skin phototype (Fitzpatrick classification I–VI) were also collected.ResultsOf 701 patients examined, 345 (49.2%) presented with a vascular discoloration of the nasal root. This was present in 97 of 193 (50.3%), 127 of 261 (48.7%), and 121 of 247 (49.0%) patients for the age groups 0–1, 1–3, and 3–6 years, respectively. The presence of vascular discoloration of the nasal root was more frequent in patients with lighter Fitzpatrick skin phototypes: 49 of 69 (71.0%) phototype II, 157 of 290 (54.1%) phototype III, and 137 of 337 (40.7%) phototype IV.ConclusionsA vascular discoloration of the nasal root is a frequent skin feature in infants and children, persisting at least until the age of 6. It does not constitute any medical problem aside from cosmetic concern and parents can be reassured of its benign nature. We propose the medical term “prominent TNRV” to describe this condition.
Generalization of savoring to novel positive stimuli
Authors: Wilson Kayla A. , MacNamara Annmarie 
Published: February 2024

AbstractSavoring is a positive emotion up‐regulation technique that can increase electrocortical and self‐reported valence and arousal to positive and neutral pictures, with effects persisting to increase response to the same stimuli when encountered later. Outside of the lab, emotion regulation techniques that persist to affect not just encounters with the same stimuli but also encounters with similar, but previously unencountered stimuli should save individuals time and effort. Here, we used event‐related potentials and picture ratings to test whether savoring would generalize to similar, but previously unseen positive pictures. To this end, 89 participants (56 female; M age = 18.96 years, SD = 1.87) were asked to savor positive pictures from one category (e.g., happy people) and to view positive pictures from another category (e.g., cute animals), as well as to view neutral pictures (e.g., plants). In a subsequent passive picture viewing task, participants viewed novel pictures from all three categories (i.e., happy people, cute animals, plants). In the first task, savoring was effective for pictures of animals throughout picture presentation, but only for pictures of people during the later part of picture presentation. In the second task, savoring generalized to novel pictures of animals, though this was only evident in the early portion of picture processing (and for self‐reported ratings). Therefore, savoring holds promise as a useful technique for increasing positive emotion in everyday life, though more work is needed to understand whether effects may vary depending on different types of picture content.
Determining intracortical, corticospinal and alpha motoneurone excitability in athletes with patellar tendinopathy compared to asymptomatic controls
Authors: Vallance Patrick , Malliaras Peter , Vicenzino Bill , Kidgell Dawson J. 
Published: February 2024

AbstractBackgroundLower capacity to generate knee extension maximal voluntary force (MVF) has been observed in individuals affected with patellar tendinopathy (PT) compared to asymptomatic controls. This MVF deficit is hypothesized to emanate from alterations in corticospinal excitability (CSE). The modulation of CSE is intricately linked to the excitability levels at multiple sites, encompassing neurones within the corticospinal tract (CST), intracortical neurones within the primary motor cortex (M1), and the alpha motoneurone. The aim of this investigation was to examine the excitability of intracortical neurones, CST neurones, and the alpha motoneurone, and compare these between volleyball and basketball athletes with PT and matched asymptomatic controls.MethodNineteen athletes with PT and 18 asymptomatic controls participated in this cross‐sectional study. Transcranial magnetic stimulation was utilized to assess CST excitability, corticospinal inhibition (silent period, and short‐interval cortical inhibition). Peripheral nerve stimulation was used to evaluate lumbar spine and alpha motoneurone excitability, including the evocation of lumbar‐evoked potentials and maximal compound muscle action potential (MMAX), and CSE with central activation ratio (CAR). Knee extension MVF was also assessed.ResultsAthletes with PT exhibited longer silent period duration and greater electrical stimulator output for MMAX, as well as lower MVF, compared to asymptomatic controls (p < 0.05).ConclusionThese findings indicate volleyball and basketball athletes with PT exhibit reduced excitability of the alpha motoneurone or the neuromuscular junction, which may be linked to lower MVF. Subtle alterations at specific sites may represent compensatory changes to excitability aiming to maintain efferent drive to the knee extensors.
Deep learning‐based quantification and transcriptomic profiling reveal a methyl jasmonate‐mediated glandular trichome formation pathway in Cannabis sativa
Authors: Huang Xiaoqin , Chen Wei , Zhao Yuqing , Chen Jingjing , Ouyang Yuzeng , Li Minxuan , Gu Yu , Wu Qinqin , Cai Sen , Guo Foqin , Zhu Panpan , Ao Deyong , You Shijun , Vasseur Liette , Liu Yuanyuan 
Published: February 2024

SUMMARYCannabis glandular trichomes (GTs) are economically and biotechnologically important structures that have a remarkable morphology and capacity to produce, store, and secrete diverse classes of secondary metabolites. However, our understanding of the developmental changes and the underlying molecular processes involved in cannabis GT development is limited. In this study, we developed Cannabis Glandular Trichome Detection Model (CGTDM), a deep learning‐based model capable of differentiating and quantifying three types of cannabis GTs with a high degree of efficiency and accuracy. By profiling at eight different time points, we captured dynamic changes in gene expression, phenotypes, and metabolic processes associated with GT development. By integrating weighted gene co‐expression network analysis with CGTDM measurements, we established correlations between phenotypic variations in GT traits and the global transcriptome profiles across the developmental gradient. Notably, we identified a module containing methyl jasmonate (MeJA)‐responsive genes that significantly correlated with stalked GT density and cannabinoid content during development, suggesting the existence of a MeJA‐mediated GT formation pathway. Our findings were further supported by the successful promotion of GT development in cannabis through exogenous MeJA treatment. Importantly, we have identified CsMYC4 as a key transcription factor that positively regulates GT formation via MeJA signaling in cannabis. These findings provide novel tools for GT detection and counting, as well as valuable information for understanding the molecular regulatory mechanism of GT formation, which has the potential to facilitate the molecular breeding, targeted engineering, informed harvest timing, and manipulation of cannabinoid production.