bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive value of comorbidities on postoperative complication rates and overall survival in left-sided oncological colorectal resections: a multicentre cohort study
Authors: Schlager Lukas , Monschein Matthias , Schüller Jessica , Bergmann Michael , Krall Christoph , Razek Peter , Stift Anton , Unger Lukas W. 
Published: October 2023

Introduction:
Surgical- and non-surgical complications significantly worsen postoperative outcomes, and identification of patients at risk is crucial to improve care. This study investigated whether comorbidities, graded by the Charlson Comorbidity Index (CCI), impact complication rates and impair long-term outcome in a cohort of left-sided colorectal resections.

Methods:
Retrospective analysis of patients undergoing oncological left-sided colorectal resections due to colorectal cancer between 01/2015 and 12/2020 in two referral centres in Austria using electronic medical records and national statistical bureau survival data. Patients with recurrent disease, peritoneal carcinomatosis, and emergency surgeries were excluded. Comorbidities were assessed using the CCI, and complication severity was defined by the Clavien Dindo classification (CDC). Logistic regression analysis was performed to identify factors influencing the risk for postoperative complications, and overall survival was assessed using data from the national statistics bureau.

Results:
A total of 471 patients were analysed. Multinominal logistic regression analysis identified a CCI ≥6 (P=0.049; OR 1.59, 95% CI 1.10-2.54) and male sex (P=0.022; OR 1.47 95%, CI 1.21-2.98) as independent risk factors for major complications. While patients with a high CCI had the worst postoperative survival rates, perioperative complications only impacted on overall survival in patients with low CCIs, but not in patients with high CCIs.

Conclusion:
Although a high CCI is a risk factor for major postoperative complications, the presence of comorbidities should not result in withholding surgery.
Defining and predicting textbook outcomes for perihilar cholangiocarcinoma: analysis of factors improving of achievement of desired post-operative outcomes. retrospective cohort study
Authors: Clocchiatti Lucrezia , Marino Rebecca , Ratti Francesca , Pedica Federica , Casadei Gardini Andrea , Lorenzin Dario , Aldrighetti Luca 
Published: October 2023

Background:
Definition of Textbook Outcome (TO), defined as a single indicator combining the most advantageous short-term outcomes, is still lacking for Perihilar Cholangiocarcinoma (PHC). The primary endpoint of the present study is to analyse the rate of achievement of a disease-specific textbook outcome for peri-hilar cholangiocarcinoma within a high volume tertiary referral center. Secondary endpoints are to identify predictive factors of TO achievement and to analyze the impact of achieving textbook outcome on long-term results.

Methods:
Between 2010 and 2022, a total of 237 patients undergoing combined liver and biliary resection for PHC at tertiary referral center were included. Disease-specific TO were defined as: no 90-days mortality, no postoperative complications, no readmission, no intraoperative transfusions and R0 margins. A logistic regression model was developed to identify predictors associated with TO achievement. Kaplan-Meier curves were designed to determine TO’s impact on survival.

Results:
TO was achieved in 60 (25.3%) patients. At multivariate logistic regression, preoperative biliary drainage (OR 2.90 (1.13 – 3.40), P=0.026), high prognostic nutritional index (OR 7.11 (6.71 – 9.43), P=0.007) and minimally-invasive approach (OR 3.57 (2.31 – 3.62), P=0.013) were identified as independent predictors of TO. High ASA score (OR 0.38 (0.17 – 0.82), P=0.013) decreased the odds of TO. A significant improvement in both overall survival and disease-free survival was associated to TO fulfilment.

Conclusion:
Since the achievement of textbook outcome correlates with better disease-free and overall survival, every effort should be made to ameliorate modifiable aspects prior to surery: management within referral centers with dedicated experience in biliary tract cancer and preoperative optimization protocol may positively contribute to improve postoperative outcomes, increasing the chance to obtain TO. Moreover, the implementation of advanced minimally invasive programs plays as well.
Magnetic resonance-guided laser interstitial thermal therapy vs. open surgery for drug-resistant mesial temporal lobe epilepsy: A propensity score matched retrospective cohort study
Authors: Mo Jiajie , Guo Zhihao , Wang Xiu , Zhang Jianguo , Hu Wenhan , Shao Xiaoqiu , Sang Lin , Zheng Zhong , Zhang Chao , Zhang Kai 
Published: October 2023

Background:
Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) and traditional open surgery (OS) are effective and safe options for patients with drug-resistant mesial temporal lobe epilepsy (DR-mTLE). However, their superiority in seizure control and preservation of functional abilities remains unclear. This study aimed to compare the surgical outcomes of MRgLITT and OS.

Materials and Methods:
This multicenter retrospective cohort study included patients with DR-mTLE who underwent MRgLITT or OS at three centers between 2015 and 2023. The data on patient demographics, presurgical non-invasive evaluation, stereoelectroencephalography (SEEG) implantation, memory alteration, and seizure outcomes were collected. A propensity score matching (PSM) analysis was conducted to minimize selection bias, facilitating a comparison of seizure control and functional preservation between two surgical approaches.

Results:
Of the 244 individuals who met the study criteria, 33 underwent MRgLITT and 211 OS. The median (IQR) age at seizure onset was 22.0 (13.0) and 12.3 (10.0) years in the MRgLITT and OS groups, respectively. The first PSM, based on demographic and non-invasive information, resulted in 26 matched pairs for the primary analysis. There were no significant differences in memory preservation (P = .95) or surgical outcomes (P = .96) between the groups. The second PSM, based on demographics and SEEG implantation, yielded 32 matched pairs for the sensitivity analysis, showing similar results. Subset analysis of early and late MRgLITT cases revealed no statistically significant differences in the proportion of patients with memory decline (P = .42) or seizure control (P = 1.00). Patients who underwent SEEG implantation were 96% less likely to achieve seizure freedom after MRgLITT (P = .02).

Conclusion:
Minimally invasive MRgLITT is associated with memory preservation and seizure control, similar to traditional OS. MRgLITT is effective and safe for DR-mTLE and is relevant for future prospective randomized trials on dominant-side mTLE, providing practical implications for guiding neurosurgeons in the selection of surgical approaches.
An unusual coincidence of giant cervical leiomyoma and incidental ovarian granulosa cell tumor: A case report
Authors: Kotowski Krzysztof , Małyszczak Paulina , Towarek Magdalena , Jagasyk Arkadiusz , Murawski Marek , Sozański Rafał 
Published: October 2023

Rationale:
Leiomyomas are the most common benign tumors of smooth muscle origin in women. They are most frequently found in the submucosal tissue of the uterine corpus; however, they also occur in other areas of the uterus, including the cervix. Their size usually varies between 0.5 to 1.0 cm; however, they can reach great dimensions. A strong correlation between the onset and growth of leiomyomas and estrogen levels was observed. Granulosa cell tumor (GCT) is an infrequent sex cord-stromal ovarian neoplasm. Despite their malignancy, GCTs have a good long-term prognosis. In this study, we present a unique case of coincidence of 2 tumors: leiomyoma of rare location (cervix uteri) and extraordinary size (9, 04 cm diameter) with an adult granulosa cell tumor.

Patient concerns:
A 67-year-old Caucasian woman was transported from an emergency ward to a gynecological surgery department due to a massive vaginal hemorrhage.

Diagnoses:
Preliminary examination showed a presence of an enormous uteri cervix tumor.

Interventions:
Initially, the patient underwent physical and ultrasound examinations. To prevent further bleeding, an urgent surgery (hysterectomy) with bilateral salpingo-oophorectomy was performed.

Outcome:
Postoperative histopathological examination revealed a cervical leiomyoma and the incidental occurrence of an adult GCT in the right ovary.

Lessons:
This case shares an interesting coincidence between a rare variant of leiomyoma and GCT. The study suggests that the potential reason for this can be estrogen secreted by the GCT, which causes the enormous size of the patient’s cervical leiomyoma and the severe vaginal bleeding. Therefore, we advise it is important in abnormal cases to search for other hidden explanations, as in cases of GCT.
Primary gastric tuberculosis was misdiagnosed as submucosal mass: A rare case report and review of literature
Authors: Feng Shuyan , He Yi , Zhang Chi , Chen Dandan , Zhong Jihong , Zhang Shuo 
Published: October 2023

Background:
Tuberculosis of stomach is the rarest form of the tuberculosis family. It is not only lacks specificity in clinical symptoms, but also lacks specificity in auxiliary examination results such as upper gastrointestinal barium meal and gastroscopy. In addition, gastric tuberculosis can coexist with gastric ulcer or gastric cancer, which is difficult to confirm the diagnosis and easy to misdiagnose.

Case summary:
We report a patient who presented with gastric discomfort as the main symptom and was diagnosed with gastric submucosal mass at a local hospital several months ago. For further endoscopic treatment, the patient came to our hospital for hospitalization.

Conclusion:
We performed endoscopic ultrasonography and histopathological biopsy for the patient, and found that the “submucosal mass” was actually a gastric tuberculosis lesion. After confirming the diagnosis of gastric tuberculosis, we transferred the patient to a tuberculosis specialist hospital for antituberculosis treatment.
Through a series of literature review, we rediscuss the diagnosis and differential diagnosis of gastric tuberculosis, aiming at improving the understanding of gastroenterologists to this disease, so as to timely diagnose and treat patients with gastric tuberculosis.
Exercise-based cardiac rehabilitation programmers for patients after transcatheter aortic valve implantation: A systematic review and meta-analysis
Authors: Li Zhanjun , Song Wei , Yang Na , Ding Yanyan 
Published: October 2023

Background:
Currently, transcatheter aortic valve implantation (TAVI) is presently a recognized treatment modality for patients with severe aortic stenosis who are often old, disabled, frail, and have low exercise capacity (ExCap). It is further expected from this therapy to improve quality of life by improving of the cardio function performance. The aim of this study is to evaluate the effect of exercise-based cardiac rehabilitation (CR) on patients after TAVI.

Methods:
PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to December 10, 2022 for relevant studies that evaluated the effect of CR on patients after TAVI. The primary outcome was the improvement of 6-minute walked distance and Barthel index score after CR. The secondary outcomes included other parameters such as SF-12 scale, HADS score, Morse Fall Scale, Frailty-Index, ExCap, and FIM score. All statistical analyses were performed using the standard statistical procedures provided in Review Manager 5.2.

Results:
A total of 12 observational studies were identified, with 2365 participants. Pooled data indicated that CR programmers significantly improved the 6-minute walked distance (SMD 0.65; 95% confidence intervals [CI] 0.51–0.79) and Barthel index score (SMD 0.83; 95% CI 0.61–1.06). In addition, compared with admission, patients experienced significant improvement in SF-12 scale at CR discharge, with a pooled mean differences (MD) of 2.74 (95% CI 0.86–4.61) in physical component score and 2.76 (95% CI 0.59–4.93) in mental component score. Similar results were also observed in ExCap (MD 8.10 W; 95% CI 1.57 W–14.63 W) and FIM score (MD 11.0; 95% CI 6.22–15.78).

Conclusions:
Our analysis indicated that exercise-based CR programmers had significant effect on patients after TAVI in improving exercise tolerance and functional independence.
Antenatal diagnosis and management of pregnancy luteoma: A case report and literature review
Authors: Shen Junhua , Li Jingyi , Tao Xia , Feng Yan , Li Baohua 
Published: October 2023

Background:
Pregnancy luoteomas are tumor-like ovarian lesions that emerge during pregnancy and spontaneously regress after delivery. Antenatal diagnosis is infrequently reported, and unnecessary surgery appears to be common in literature reports.

Case summary:
A 28-year-old primigravida with bilateral adnexal masses was discovered at 32 + 5 weeks during prenatal ultrasound evaluation. Combined with clinical presentation, auxiliary examinations including blood test, magnetic resonance imaging, gastroscopy, and consultation of multi-disciplinary team, we successfully made a diagnosis of pregnancy luteoma and provided conservative management recommendations. A cesarean section was conducted on this patient at 34 + 2 weeks of gestation due to fetal distress. The newborn was small for gestational age but normal in appearance. We performed biopsies of the adnexal masses, which were confirmed to be pregnancy luteomas using both intraoperative frozen section and final pathological diagnosis. Serum testosterone, cancer antigen 125, and alpha-fetoprotein levels gradually declined and normalized on postoperative day 28. The masses significantly decreased in size as shown by ultrasonic and magnetic resonance imaging examination on postoperative day 7, with the ovaries returning to their normal size by postoperative day 30.

Conclusion:
Prenatal diagnosis of pregnancy luteoma poses a challenge, requiring hormonal examinations, ultrasound, magnetic resonance imaging, and gastrointestinal endoscopy for identification. Caution must be exercised to avoid overtreatment. While additional cases are needed to summarize the imaging features and effects of excess hormones on the both mother and fetus, further research is necessary for a comprehensive understanding.
Integrated bioinformatics analysis and network pharmacology to explore the potential mechanism of Patrinia heterophylla Bunge against acute promyelocytic leukemia
Authors: Feng Liya , Zhu Sha , Ma Jian , Hong Yali , Wan Meixia , Qiu Qian , Li Hongjing , Li Juan 
Published: October 2023

Introduction:
Current treatment with arsenic trioxide and all-trans retinoic acid has greatly improved the therapeutic efficacy and prognosis of acute promyelocytic leukemia (APL), but may cause numerous adverse effects. Patrinia heterophylla Bunge (PHEB), commonly known as “Mu-Tou-Hui” in China, is effective in treating leukemia. However, no studies have reported the use of PHEB for APL treatment. In this study, we aimed to investigate the potential anticancer mechanism of PHEB against APL.

Methods:
Public databases were used to search for bioactive compounds in PHEB, their potential targets, differentially expressed genes associated with APL, and therapeutic targets for APL. The core targets and signaling pathways of PHEB against APL were identified by the protein–protein interaction network, Kaplan–Meier curves, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment, and compound-target-pathway network analysis. Molecular docking was performed to predict the binding activity between the most active compounds and the key targets.

Results:
Quercetin and 2 other active components of PHEB may exert anti-APL effects through proteoglycans in cancer, estrogen signaling, and acute myeloid leukemia pathways. We also identified 6 core targets of the bioactive compounds of PHEB, including protein tyrosine phosphatase receptor type C, proto-oncogene tyrosine-protein kinase Src, mitogen-activated protein kinase phosphatase 3 (MAPK3), matrix metalloproteinase-9, vascular endothelial growth factor receptor-2, and myeloperoxidase, most of which were validated to improve the 5-year survival of patients. Molecular docking results showed that the active compound bound well to key targets.

Conclusion:
The results not only predict the active ingredients and potential molecular mechanisms of PHEB against APL, but also help to guide further investigation into the anti-APL application of PHEB.
Research trends in chemogenetics for neuroscience in recent 14 years: A bibliometric study in CiteSpace
Authors: Chen Yuerong , Xu Yunyun , Dai Jiale , Ni Wenqin , Ding Qike , Wu Xinyuan , Fang Jianqiao , Wu Yuanyuan 
Published: October 2023

Background:
Chemogenetics has been widely adopted in Neuroscience. Neuroscience has become a hot research topic for scientists. Therefore, the purpose of this study is to explore the current status and trends in the global application of chemogenetics in neuroscience over the last 14 years via CiteSpace.

Methods:
Publications related to chemogenetics in neuroscience were retrieved from the Science Citation Index-Extended Web of Science from 2008 to 2021. We used CiteSpace to analyze publications, citations, cited journals, countries, institutions, authors, cited authors, cited references, and keywords.

Results:
A total of 947 records were retrieved from 2008 to 2021 on February 21, 2022. The number and rate of publications and citations increased significantly. Journal of Neuroscience was the most cited journal, and BRAIN RES BULL ranked first in the centrality of cited journals. The United States of America (USA) had the highest number of publications among the countries. Takashi Minamoto was the most prolific author and Armbruster BN ranked the first among authors cited. The first article in the frequency ranking of the references cited was published by Roth BL. The keyword of “nucleus accumben (NAc)” had the highest frequency. The top 3 keywords with the strongest citation bursts include “transgenic mice,” “cancer,” and “blood-brain barrier.”

Conclusion:
The period 2008 to 2021 has seen a marked increase in research on chemogenetics in neuroscience. The application of chemogenetics is indispensable for research in the field of neuroscience. This bibliometrics study provides the current situation and trend in chemogenetic methods in neuroscience in recent 14 years, which may help researchers to identify the hot topics and frontiers for future studies in this field.
Efficacy and safety of acupuncture therapy combined with conventional pharmacotherapy in the treatment of systemic lupus erythematosus: A systematic review and meta-analysis
Authors: Wang Hanzheng , Wang Baizhou , Huang Jinge , Yang Zi , Song Ziyu , Zhu Qingmiao , Xie Zhijun , Sun Qice , Zhao Ting 
Published: October 2023

Background:
Currently, the mainstream treatments for systemic lupus erythematosus (SLE) are based on glucocorticoids and immunosuppressants, which are known to have considerable adverse effects. This meta-analysis is aimed at confirming the efficacy and safety of acupuncture therapy in combination with traditional medications in the treatment of SLE.

Methods:
Multiple databases were searched for randomized controlled trials using acupuncture therapy in combination with conventional pharmacotherapy for the treatment of SLE, from the establishment of the database to March 2023. Study selection, data collection, as well as quality assessment were conducted by 2 reviewers independently. RevMan 5.4 and Stata 17 software were used for Meta-analysis.

Results:
Seven eligible studies involving 514 patients with SLE were included. Meta-analysis demonstrated that in SLE patients, extra treatment with acupuncture was superior to drug therapy alone in improving the overall response rate (RR = 1.20, 95% confidence intervals [1.11, 1.29], P < .00001, heterogeneity P = .69, I2 = 0%) and regulating immunological indicators (C3, C4, IgG, T lymphocyte subpopulation, IL-6, ds-DNA, ESR) while reducing TCM symptom scores, the SLE Disease Activity Index (SLEDAI) and the incidence of adverse events on treatment (P ≤ 0.05). Additionally, it was able to reduce BUN, Scr and 24 hours urine protein, suggesting that acupuncture treatment had a protective effect on the kidneys.

Conclusions:
Acupuncture therapy combined with conventional pharmacotherapy is an efficient and safe way in the treatment of SLE. However, the conclusions drawn from this meta-analysis have some limitations due to the small number and uneven quality of the included studies, leading to heterogeneity and bias. Thus more relevant high-quality randomized controlled trials are needed for further evaluation in the future.
Effect of different interventions on the efficacy of postpartum urinary incontinence in China: A systematic review and network meta-analysis
Authors: Liu Du chen , Gao Lei , Liu Ying , Wang Jianhua , Li Ying , Xu Ruo yuan 
Published: October 2023

Background:
Currently, numerous treatment measures exist for postpartum stress urinary incontinence (PSUI); however, the study results are inconsistent.

Method:
Computer searches of PubMed, Embase, Web of Science, CKNI, and Wanfang databases were conducted to search the literature on 13 different intervention modalities for PSUI from the date of establishment to January 2023 for analysis. The literature was independently screened, and the information was extracted by 2 researchers. A reticulated meta-analysis was conducted using Stata software.

Results:
The findings of the reticulated meta-analysis revealed that, in terms of the effectiveness of the 13 interventions for treating PSUI from highest to lowest, the most effective was acupressure + pelvic floor muscle training (94.6%). Following this, the interventions ranked from best to worst were electroacupuncture + trans moxibustion (79.1%), pelvic floor muscle training + acupuncture (64.3%), pelvic floor muscle training + pelvic floor electrical stimulation (60.3%), biofeedback electrical stimulation + acupuncture (60.0%), pelvic floor muscle training + biofeedback electrical stimulation (59.8%), biofeedback electrical stimulation + acupuncture + herbal hot compresses (56.6%), moxibustion + pelvic floor muscle training (56.6%), pelvic floor muscle training + pelvic floor electrical stimulation + acupuncture (53.1%), biofeedback electrical stimulation + moxibustion (52.1%), pelvic floor muscle training (17.6%), biofeedback electrical stimulation (16.1%), and health coaching (0.2%). The evidence indicates that acupressure + pelvic floor muscle training may be the most effective intervention for treating PSUI occurrence.

Conclusion:
Improvement in 13 clinical indicators was observed in patients with PSUI, and significant enhancement was achieved through acupressure + pelvic floor muscle training.