bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of ultraprocessed foods consumption and cognitive function among children aged 4–7 years: a cross-sectional data analysis
Authors: Liu Shun , Mo Caimei , Lei Lidi , Lv Fangfang , Li Jinxiu , Xu Xuemei , Lu Peini , Wei Gangjie , Huang Xuanqian , Zeng Xiaoyun , Qiu Xiaoqiang 
Published: October 2023

BackgroundSugar-sweetened beverage (SSB) consumption has shown associations with cognitive function in preschool children, but effects of other ultraprocessed foods consumption are rarely discussed in China. This study aimed to investigate the relationship between ultraprocessed food consumption and cognitive function among preschool children in China.MethodsA total of 325 children aged 4–7 years were included from Guangxi Zhuang Birth Cohort in Guangxi Zhuang Autonomous Region, China. Face-to-face interviews with parents using the Food Frequency Questionnaire (FFQ) was conducted to investigate the status of seven ultraprocessed foods consumption (i.e., chocolate, biscuits, candy, fast-food, ice cream, SSBs, and sweet bakery products). The mandarin-language version of the Wechsler Preschool and Primary Scale of Intelligence (WPPSI, Fourth Edition) was applied to assess the cognitive function of children. Multiple linear and logistic regression models were used to assess the associations between ultraprocessed food consumption and the full-scale intelligence quotient (FSIQ) and different domains and risk of cognitive deficit, respectively.ResultsWe found that frequent consumption of candy (β = −3.34, 95% CI: −5.62∼−1.06; p = 0.004) and sweet bakery products (β = −2.77, 95% CI: −5.58∼0.04; p = 0.054) were significant associated with decreased FSIQ scores in the linear regression models. However, only frequent consumption of candy was statistically significantly associated with an increased risk of cognitive deficit (OR = 2.05, 95% CI: 1.11∼3.79; p = 0.023) in the logistic regression models. For the different domains, we found frequent consumption of candy (β = −3.85, 95% CI: −6.28∼−1.43; p = 0.002) and sweet bakery products (β = −3.48, 95% CI: −6.47∼−0.49; p = 0.023) was also significantly associated with lower Verbal Comprehension Index (VCI). When combining the seven ultraprocessed foods, we found children who frequently consumed more than two kinds of ultraprocessed foods had a significant decrease of VCI scores (β = −2.66; 95% CI: −5.12∼−0.19; p = 0.035) too.ConclusionOur results suggested that frequent consumption of individual (candy and sweet bakery products) and multiple ultraprocessed foods may decrease VCI scores and thereby impact cognitive function in children aged 4–7 years.
Rapid multi-task diagnosis of oral cancer leveraging fiber-optic Raman spectroscopy and deep learning algorithms
Authors: Li Xing , Li Lianyu , Sun Qing , Chen Bo , Zhao Chenjie , Dong Yuting , Zhu Zhihui , Zhao Ruiqi , Ma Xinsong , Yu Mingxin , Zhang Tao 
Published: October 2023

IntroductionOral cancer, a predominant malignancy in developing nations, represents a global health challenge with a five-year survival rate below 50%. Nonetheless, substantial reductions in both its incidence and mortality rates can be achieved through early detection and appropriate treatment. Crucial to these treatment plans and prognosis predictions is the identification of the pathological type of oral cancer.MethodsToward this end, fiber-optic Raman spectroscopy emerges as an effective tool. This study combines Raman spectroscopy technology with deep learning algorithms to develop a portable intelligent prototype for oral case analysis. We propose, for the first time, a multi-task network (MTN) Raman spectroscopy classification model that utilizes a shared backbone network to simultaneously achieve different clinical staging and histological grading diagnoses.ResultsThe developed model demonstrated accuracy rates of 94.88%, 94.57%, and 94.34% for tumor staging, lymph node staging, and histological grading, respectively. Its sensitivity, specificity, and accuracy compare closely with the gold standard: routine histopathological examination.DiscussionThus, this prototype proposed in this study has great potential for rapid, non-invasive, and label-free pathological diagnosis of oral cancer.
A novel, simple near-infrared thoracoscopic technique by a particular route for locating lung nodules
Authors: Li Zhengjun , Xia Mozhu , Liu Chang , Xie Liwei , Wang Tao , Ren Yi 
Published: October 2023

BackgroundThe localization of pulmonary nodules prior to thoracoscopic surgery remains challenging for thoracic surgeons, especially for those nodules that are not visible or palpable on the lung surface. Our study is a simple and effective minimally invasive method using indocyanine green through a special pathway to locate pulmonary nodules and fluorescence thoracoscopic surgery.MethodsThoracoscopic surgery was performed for 18 undiagnosed peripheral non-solid nodules no larger than 2 cm after location. After 0.3 mg/kg indocyanine green was injected through the peripheral vein, the puncture needle was pulled out after it reached approximately 1 cm of the pulmonary parenchyma near the nodules. This was followed by transfer to the operating room. The nodule was initially localized by using a near-infrared thoracoscope to visualize indocyanine green fluorescence. Then, thoracoscopic resection was performed.ResultsEighteen patients received this special and simple localization method, and underwent near-infrared, image-guided, video-assisted thoracoscopic surgery resection. Median computed tomography (CT) tumor size was 1.2 cm. Median depth from the pleural surface is 1.6 cm (range, 0.1–4.6 cm). The median time of CT-guided intervention was 12 min. The duration of thoracoscopic surgery was 67 min. Indocyanine green fluorescence was clearly identified in 17 of 18 patients (94.4%). The surgical margins were all negative on final pathology. The final diagnoses included 17 primary lung cancers, and 1 benign lung tumor.ConclusionsCT-guided single puncture of indocyanine green after peripheral intravenous injection is a simple, effective, and safe method to locate the nodule. This offers surgeons the ease of localization through direct indocyanine green fluorescence imaging, and it can be used as an effective alternative to other placement methods of locating pulmonary nodules.
Musculoskeletal adverse events induced by immune checkpoint inhibitors: a large-scale pharmacovigilance study
Authors: Liu Hao , Li Yumin , Li Jie , Zhang Qiongchi , Wu Jingtao , Li Xinyu , Meng Liesu , Cao Shuai , Li Haopeng 
Published: October 2023

Background: The musculoskeletal toxicity of immune checkpoint inhibitors (ICIs) is receiving increasing attention with clinical experience. Nevertheless, the absence of a systematic investigation into the musculoskeletal toxicity profile of ICIs currently results in the under-recognition of associated adverse events. Further and more comprehensive investigations are warranted to delineate the musculoskeletal toxicity profile of ICIs and characterize these adverse events.Material and methods: The present study employed the FDA Adverse Event Reporting System database to collect adverse events between January 2010 and March 2021. We utilized both the reporting odds ratio and the Bayesian confidence propagation neural network algorithms to identify suspected musculoskeletal adverse events induced by ICIs. Subsequently, the clinical characteristics and comorbidities of the major musculoskeletal adverse events were analyzed. The risk of causing these events with combination therapy versus monotherapy was compared using logistic regression model and Ω shrinkage measure model.Results: The musculoskeletal toxicity induced by ICIs primarily involves muscle tissue, including neuromuscular junctions, fascia, tendons, and tendon sheaths, as well as joints, spine, and bones, including cartilage. The toxicity profile of PD-1/PD-L1 and CTLA-4 inhibitors varies, wherein the PD-1 inhibitor pembrolizumab exhibits a heightened overall risk of inducing musculoskeletal adverse events. The major ICIs-induce musculoskeletal adverse events, encompassing conditions such as myositis, neuromyopathy (including myasthenia gravis, Lambert-Eaton myasthenic syndrome, Guillain-Barré syndrome, and Chronic inflammatory demyelinating polyradiculoneuropathy), arthritis, fractures, myelitis, spinal stenosis, Sjogren’s syndrome, fasciitis, tenosynovitis, rhabdomyolysis, rheumatoid myalgia, and chondrocalcinosis. Our study provides clinical characteristics and comorbidities of the major ICIs-induced musculoskeletal adverse events. Furthermore, the combination therapy of nivolumab and ipilimumab does not result in a statistically significant escalation of the risk associated with the major musculoskeletal adverse events.Conclusion: Immune checkpoint inhibitors administration triggers a range of musculoskeletal adverse events, warranting the optimization of their management during clinical practice.
The zhuyu pill relieves rat cholestasis by regulating the mRNA expression of lipid and bile metabolism associated genes
Authors: Han Jun , Wu Peijie , Wen Yueqiang , Liu Chao , Liu Xinglong , Tao Huan , Zhang Fenghua , Zhang Xiaodan , Ye Qiaobo , Shen Tao , Chen Xiaofeng , Yu Han 
Published: October 2023

Background: The Zhuyu pill (ZYP), composed of Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, is an effective traditional Chinese medicine with potential anti-cholestatic effects. However, the underlying mechanisms of ZYP remain unknown.Objective: To investigate the mechanism underlying the interventional effect of ZYP on mRNA-seq analysis in cholestasis rat models.Materials and methods: This study tested the effects of a low-dose (0.6 g/kg) and high-dose (1.2 g/kg) of ZYP on a cholestasis rat model induced by α-naphthyl-isothiocyanate (ANIT, 50 mg/kg). Serum biochemistry and histopathology results were used to evaluate the therapeutic effect of ZYP, and mRNA-Seq analysis was performed and verified using real-time fluorescence quantitative PCR (qRT-PCR). GO, KEGG, and GSEA analyses were integrated to identify the mechanism by which ZYP impacted cholestatic rats.Results: ZYP was shown to significantly improve abnormal changes in the biochemical blood indexes and liver histopathology of cholestasis rats and regulate pathways related to bile and lipid metabolism, including fatty acid metabolism, retinol metabolism, and steroid hormone biosynthesis, to alleviate inflammation, cholestasis, and lipid metabolism disorders. Relative expression of the essential genes Cyp2a1, Ephx2, Acox2, Cyp1a2, Cyp2c11, and Sult2a1 was verified by qRT-PCR and showed the same trend as mRNA-seq analysis.Conclusion: ZYP has a significant anti-cholestatic effect by regulating bile metabolism and lipid metabolism related pathways. These findings indicate that ZYP is a novel and promising prospect for treating cholestasis.
Dynamic 18F-FDG-PET kinetic parameters for epileptogenic zone localization in drug-resistant epilepsy
Authors: Khamwan Kitiwat , Sukprakun Chanan , Limotai Chusak , Jirasakuldej Suda , Jantarato Attapon , Hemachudha Thiravat , Tepmongkol Supatporn 
Published: October 2023

Objective: Precisely localizing the seizure onset zone remains a challenging task in drug-resistant epilepsy (DRE) patients especially given its critical role in successful surgery and effective management. This study aimed to investigate the kinetic parameters of regional 18F-fluorodeoxyglucose (FDG) uptake in DRE patients, aiming to identify the kinetic parameters best enabling the identification of the epileptogenic region.Methods: Consecutive DRE patients with clinically mandated interictal 18F-FDG PET/CT were recruited from October 2019 to September 2020 for pre-surgical evaluation. Immediately after injecting 18F-FDG of 112–179 MBq, dynamic data were acquired for 90 min. The motion correction and resampling to the Montreal atlas was performed in order to generate a transformation matrix. 116 volume of interests (VOIs) and regional time-activity curves (TACs) were generated by employing the automated anatomical labeling (AAL) template using PMOD software. Kinetic parameters of FDG unidirectional blood-brain clearance (K1), efflux (k2), phosphorylation (k3), and net metabolic flux (Ki) were derived using irreversible 2-tissue-compartment model with an image-derived input function (IDIF). The kinetic parameters values obtained from all regions were ranked and compared with the presumed epileptogenic zone (EZ).Results: Eleven DRE patients (5 males, 6 females, mean age 35.1 ± 10.2 years) were analyzed. We found that the region with the lowest values of Ki provided correct lateralization in 7/7 (100%) of patient with temporal lobe epilepsy (TLE) and the region with the lowest Ki and k3 parameters showed concordance with the EZ in 100% and 71.4% of patients, respectively.Conclusion: The present parametric approach to the evaluation of FDG-PET may be more sensitive than semi-quantitative approaches for the detection of pathophysiology in the EZ of patients with medically unresponsive TLE in addition to the routine clinical investigations.
Remote fruit fly detection using computer vision and machine learning-based electronic trap
Authors: Molina-Rotger Miguel , Morán Alejandro , Miranda Miguel Angel , Alorda-Ladaria Bartomeu 
Published: October 2023

IntroductionIntelligent monitoring systems must be put in place to practice precision agriculture. In this context, computer vision and artificial intelligence techniques can be applied to monitor and prevent pests, such as that of the olive fly. These techniques are a tool to discover patterns and abnormalities in the data, which helps the early detection of pests and the prompt administration of corrective measures. However, there are significant challenges due to the lack of data to apply state of the art Deep Learning techniques.MethodsThis article examines the detection and classification of the olive fly using the Random Forest and Support Vector Machine algorithms, as well as their application in an electronic trap version based on a Raspberry Pi B+ board.ResultsThe combination of the two methods is suggested to increase the accuracy of the classification results while working with a small training data set. Combining both techniques for olive fly detection yields an accuracy of 89.1%, which increases to 94.5% for SVM and 91.9% for RF when comparing all fly species to other insects.DiscussionThis research results reports a successful implementation of ML in an electronic trap system for olive fly detection, providing valuable insights and benefits. The opportunities of using small IoT devices for image classification opens new possibilities, emphasizing the significance of ML in optimizing resource usage and enhancing privacy protection. As the system grows by increasing the number of electronic traps, more data will be available. Therefore, it holds the potential to further enhance accuracy by learning from multiple trap systems, making it a promising tool for effective and sustainable fly population management.
Phenomenological characteristics of autobiographical future thinking in nurses with burnout: a case-control study
Authors: Xue Bowen , Feng Yaping , Zheng Jie , Li Xin , Zhao Yihui , Yang Xiaoshan , Zhang Yu , Wang Shujin , Hu Zhiguo , Luo Hong 
Published: October 2023

ObjectiveNurses constitute the largest group of healthcare workers worldwide, and job burnout is very common among them. This study aims to explore abnormal future thinking in nurses with burnout. Additionally, the study investigates whether these manifestations worsen as burnout progresses.MethodsThe study was conducted in inpatient ward nurses at a tertiary hospital in Hangzhou, China. In the first phase, two group of nurses were recruited: nurses with burnout (N = 70) and nurses without burnout (N = 70). In the second phase, three groups were recruited according to the burnout levels: mild burnout (N = 43), moderate burnout (N = 42) and severe burnout (N = 43). Data on job burnout were obtained using the Chinese Maslach Burnout Inventory. The Sentence Completion for Events in the Future Test (SCEFT) was employed to measure the content of future thinking, which was evaluated by two raters in terms of the specificity, emotional valence, and concrete content of the imagined future events. The proportions of specific types of events among all the produced events were calculated.ResultsThe results revealed that nurses with burnout, compared to nurses without burnout, imagined fewer specific future events, positive events, and events related to relationships and achievement. They also had more omissions. As the level of burnout increased, their impairment in future thinking worsened. Furthermore, the results also revealed that the scores of emotional exhaustion, depersonalization, and personal accomplishment had significant correlations with the proportions of positive events and events related to relationships and achievement/mastery in nurses’ future thinking content.ConclusionThe future thinking ability of nurses with burnout was impaired, and this impairment worsened as the symptoms of burnout progressed. The findings of the present study have important implications for nurse caring and advocate effective interventions targeting positive future thinking to mitigate nurses’ burnout.
The association between emotion malleability beliefs and severe psychological distress stratified by sex, age, and presence of any psychiatric disorders
Authors: Sasaki Yohei , Okubo Ryo , Takeda Kazuyoshi , Ikezawa Satoru , Tabuchi Takahiro , Shirotsuki Kentaro 
Published: October 2023

BackgroundRecent studies have shown an association between psychological distress and emotion malleability beliefs, meaning mindsets about whether one’s emotions are fixed or changeable. However, most studies have not examined the association between these beliefs and sociodemographic factors.MethodsA nationwide cross-sectional Internet survey of residents of Japan aged 15–79 years was conducted using sampling weights for national estimates to investigate the association between emotion malleability beliefs and sociodemographic factors and between fixed beliefs and severe psychological distress (SPD). SPD was defined as a Kessler 6 Scale score of ≥13. Adjusted odds ratios for SPD were calculated considering potential confounders. Further analyses were stratified by sex, age and presence of any psychiatric disorder.ResultsThe analysis included 23,142 participants (female, 48.64%). Fixed beliefs were associated with female sex, age &lt; 45 years, and presence of psychiatric disorders. These beliefs were associated with SPD, and additional analysis showed stronger associations with SPD among female respondents, respondents aged 45–59 years, and those aged ≥60 years.ConclusionResults indicate that female sex, age &lt; 45 years, and current mental disorders were associated with fixed emotion malleability beliefs. Associations between fixed emotion malleability beliefs and SPD were particularly strong among female respondents and people aged ≥45 years compared with the general population. Our study extends the association between emotion malleability beliefs and psychological health to the general population. Future studies should explore mechanisms underlying individual differences in emotion beliefs.
Mothers’ experiences and perceptions about care provided during home deliveries in Alwa sub county, Kaberamaido district, Uganda– a qualitative study
Authors: Dektar Benbella , Beckford Anita Normans , Kemba Jonny , Crayson Belinda 
Published: October 2023

IntroductionIn Uganda 27% of deliveries take place outside a health facility. The existing gaps in quality of maternal and newborn health care must be addressed for Uganda to attain its health targets and consequently its economic targets. Some of the gaps include but are not limited to; ill-equipped healthcare facilities in rural settings, inadequate client/customer care skills by healthcare providers, and health worker absenteeism especially in the night hours. In Kaberamaido District, only 38.3% of the deliveries in Alwa sub county took place at a health facility. Despite the district local government and stakeholder efforts to promote health facility-based deliveries, sadly, a very low proportion of women use the health facilities for delivery. We sought to explore mothers’ experiences and perceptions about care provided during home deliveries in Alwa sub county, Kaberamaido district.MethodsThe study adopted a cross-sectional descriptive qualitative design. We purposively included 115 mothers who delivered outside the health facility and consented to participate and those who lost their babies within the last 24 months preceding the study. Other participants included in the study were village health team (VHT), traditional birth attendants (TBA) and older women. The main instruments used to collect data were focus group discussion (FGD) and in-depth interview (IDI) guides. All voice recordings from FGDs and interviews were transcribed and translated from the local language (Kumam) into English. Thematic content analysis was used to synthesize data by applying codes to segments of the transcripts upon which major domains were derived. Key findings were synthesized and quotes were carefully selected based on their relevance and representativeness to the analysis and study objective.ResultsOur findings indicated general satisfaction with the care provided during and after home delivery by TBAs as expressed by mothers. Motivation to seek services from TBAs was attributable to their vast experience spanning decades with history of safe delivery. Few mothers expressed discontent with TBA services citing abuse and rudeness.DiscussionOur study underscored the common view that TBAs effectively managed home deliveries, providing satisfactory care to mothers. However, concerns emerged on TBAs’ capacity to manage complications, emphasizing a need for their reintegration into formal healthcare systems, alongside further training, and standardization in maternal care practices.
Assessing healthcare capacity crisis preparedness: development of an evaluation tool by a Canadian health authority
Authors: Gomes Chaves Breitner , Alami Hassane , Sonier-Ferguson Brigitte , Dugas Erika N. 
Published: October 2023

IntroductionThe COVID-19 pandemic presented health systems across the globe with unparalleled socio-political, ethical, scientific, and economic challenges. Despite the necessity for a unified, innovative, and effective response, many jurisdictions were unprepared to such a profound health crisis. This study aims to outline the creation of an evaluative tool designed to measure and evaluate the Vitalité Health Network’s (New Brunswick, Canada) ability to manage health crises.MethodsThe methodology of this work was carried out in four stages: (1) construction of an evaluative framework; (2) validation of the framework; (3) construction of the evaluative tool for the Health Authority; and (4) evaluation of the capacity to manage a health crisis.ResultsThe resulting evaluative tool incorporated 8 dimensions, 74 strategies, and 109 observable elements. The dimensions included: (1) clinical care management; (2) infection prevention and control; (3) governance and leadership; (4) human and logistic resources; (5) communication and technologies; (6) health research; (7) ethics and values; and (8) training. A Canadian Health Authority implemented the tool to support its future preparedness.ConclusionThis study introduces a methodological strategy adopted by a Canadian health authority to evaluate its capacity in managing health crises. Notably, this study marks the first instance where a Canadian health authority has created a tool for emergency healthcare management, informed by literature in the field and their direct experience from handling the SARS-CoV-2 pandemic.