bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report: Castleman disease treated by the trinity of internal and external treatment of “Fuzheng, phlegm-resolving, and detoxification method”
Authors: Yuan Xinbei , Fu Hua , Xu Min , Shen Wei , Zhou Wenyi , Li Xi , Gan Xinjin 
Published: February 2024

Rationale:
Castleman disease (CD) was first included in the CSCO lymphoma diagnosis and treatment guidelines in 2021. Its diagnosis relies on lymph node pathological examination. Observation, surgical resection of the lesion, radiotherapy, chemotherapy, and medical therapy (e.g., rituximab, siltuximab, steroids) can be used. Due to the traumatic, incurable, and recurrent nature of surgical treatment, drug therapy has many side effects and is expensive. Exploring effective traditional Chinese medicine (TCM) comprehensive treatment methods for this disease is important and necessary.

Patient concerns:
The main symptom was recurrent lymphadenopathy, which had been surgically removed 5 times in the past. This time, lymph node enlargement occurred again, and the local hospital recommended surgical resection again. The patient could not tolerate another surgical treatment. Other targeted treatments are not available due to financial constraints.

Diagnoses:
The case was diagnosed as CD by pathological examination, which is an important basis for the diagnosis of this disease.

Interventions:
The patient was treated with surgery in the early stage several times, later came to our hospital for the trinity of TCM integrated treatment program, which combines oral TCM with external application of TCM and intravenous drip of TCM as a syndrome of positive deficiency and phlegm-toxin internalization, and the therapeutic principle.

Outcomes:
After nearly 3 years of comprehensive treatment with TCM, the enlarged lymph nodes could not be touched, and there was no fatigue, fever, or weight loss. During this period, the patient did not undergo surgery, chemotherapy and other western medicine treatment, and lived a normal life. It not only met the patient’s expectation but also confirmed that the TCM treatment was indeed effective.

Lessons:
This case report confirms that TCM is safe and effective in the treatment of CD, which is worthy of promotion. In clinical practice, the individualized treatment for the patient, the duration of treatment, and the different disease states also affect the treatment outcome.
Ornidazole induced Stevens–Johnson syndrome without body surface involved: A case report
Authors: Bai Hehe , Wang Xiaodong , Wang Yuanji , Li Yanhong , Guo Weiyan , Lv Juan , Li Yamei , Hao Zhaoqin , Pan Xiaoyan 
Published: February 2024

Rationale:
Ornidazole is a synthetic nitroimidazole derivative that is commonly prescribed for antiparasitic or anti-anaerobic infections. It is generally well tolerated, with known side effects including gastrointestinal tract, anaphylaxis, and central nervous system reactions. Ornidazole-induced binocular reactive keratitis and several mucocutaneous lesions have been rarely reported.

Patient concerns:
A 52-year-old woman who suffered from vaginitis and received an ornidazole vaginal plug (0.5 g). Approximately 20 minutes after the suppository was inserted into the vagina, her lips were swollen and valva and labia were burning. Her eyes were red, sore, and watery.

Diagnosis:
She was diagnosed as Steven–Johnson syndrome by the ophthalmologist. According to the Naranjo scale, the adverse drug reaction was evaluated to be probable and severe.

Interventions:
Dexamethasone was intravenous administrated as anti-inflammatory therapy for 10 days. Eye drops were locally given to relieve edema and promote healing of the epithelium. The symptoms of her eyes, lips, vulva and crissum were soon relieved.

Outcomes:
The patient was discharge from hospital with improved symptoms.

Lessons:
In order to avoid severe adverse effect, the patient should not use metronidazole ether orally or vaginally. The case emphasized the importance of rapid and accurate diagnosis of Steven–Johnson syndrome induced by ornidazole vaginal plug, especially when the eye symptoms were the chief complaint without body skin involved.
18F-FDG PET/CT Findings of Tibia Metastasis From Endometrial Adenocarcinoma
Authors: Chen Jian , Ma Liqiong , Zhao Tingting , Yang Jiqin , Li Yanmei 
Published: February 2024

Abstract
Bone metastases from endometrial carcinoma are rare, especially when the bone is the sole metastatic site. A 55-year-old woman with a history of endometrial carcinoma was referred for FGD PET/CT scan due to pain in the left knee. The images showed that multiple lesions with intense activity were detected in the left tibia. Histopathological examination and immunohistochemistry of the left tibial lesion confirmed metastases from the endometrial adenocarcinoma.
Postoperative Hyperamylasemia (POH) is an Early Predictor of Pancreatic Fistula Occurrence and Severity after Distal Pancreatectomy
Authors: Perri Giampaolo , Romandini Elisa , Marchegiani Giovanni , Ghorbani Poya , Sahakyan Musheg , Holmberg Marcus , Cattelani Alice , Fretland Åsmund , Montorsi Roberto , Rodrigues Isabella D , Kleive Dyre , Bannone Elisa , Edwin Bjørn , Gilg Stefan , Labori Knut , Sparrelid Ernesto , Salvia Roberto 
Published: February 2024

Objectives:
The aim of this international multicentric study is to characterize postoperative hyperamylasemia (POH) after distal pancreatectomy (DP), with particular focus on its relationship with postoperative pancreatic fistula (POPF) occurrence and severity.

Background
The clinical relevance of POH after DP and its relationship with the occurrence and severity of POPF have not been explored yet.

Methods
All patients undergoing DP for any indication between 2015 and 2021 at three European referral Centers for pancreatic surgery were retrospectively analyzed. Drain fluid amylase (DFA), C-reactive protein (C-RP), and serum amylase were examined from postoperative-day (POD) 1 to 3. Biochemical leak (BL), POPF, POH, and post-pancreatectomy hemorrhage (PPH) were defined and graded according to ISGPS definitions.

Results
In total 1192 patients were included. Overall rates of POH and POPF were 18% (n= 210) and 29% (n= 344), respectively. The presence of DFA ≥2000 U/L on POD 1 (OR=2.11, 95% CI 1.68-2.86), C-RP ≥200 mg/L on POD 3 (OR=2.19, 95% CI 1.68-2.86), and POH (OR=1.58, 95% CI 1.14-2.19) were all independent early predictors of POPF (all P< 0.01). The presence of POH almost doubled the rate of POPF (43% vs. 26%, P<0.001), and higher POPF severity presented also higher POH rates (no POPF= 12%; BL= 19%; B POPF= 24%; C POPF= 52%). Among patients developing POPF, patients with POH had higher rates of PPH (22% vs 9%, P= 0.001), sepsis (24% vs 13%; P=0.011), re-operation (21% vs 8%; P< 0.01), and mortality (3% vs 0.3%; P= 0.025).

Conclusions:
The occurrence of POH is an early predictor of POPF and its severity after DP. The diagnosis of POH might define patients at higher risk for a complicated course, targeting them for prevention / mitigation strategies against pancreas specific complications.
Pediatric Intraoperative Neurophysiologic Mapping and Monitoring in Brain Surgery
Authors: Alsallom Faisal , Simon Mirela V. 
Published: February 2024

Summary:
Similar to adults, children undergoing brain surgery can significantly benefit from intraoperative neurophysiologic mapping and monitoring. Although young brains present the advantage of increased plasticity, during procedures in close proximity to eloquent regions, the risk of irreversible neurological compromise remains and can be lowered further by these techniques. More so, pathologies specific to the pediatric population, such as neurodevelopmental lesions, often result in medically refractory epilepsy. Thus, their successful surgical treatment also relies on accurate demarcation and resection of the epileptogenic zone, processes in which intraoperative electrocorticography is often employed. However, stemming from the development and maturation of the central and peripheral nervous systems as the child grows, intraoperative neurophysiologic testing in this population poses methodologic and interpretative challenges even to experienced clinical neurophysiologists. For example, it is difficult to perform awake craniotomies and language testing in the majority of pediatric patients. In addition, children may be more prone to intraoperative seizures and exhibit afterdischarges more frequently during functional mapping using electrical cortical stimulation because of high stimulation thresholds needed to depolarize immature cortex. Moreover, choice of anesthetic regimen and doses may be different in pediatric patients, as is the effect of these drugs on immature brain; these factors add additional complexity in terms of interpretation and analysis of neurophysiologic recordings. Below, we are describing the modalities commonly used during intraoperative neurophysiologic testing in pediatric brain surgery, with emphasis on age-specific clinical indications, methodology, and challenges.
Mapping Stress-Responsive Signaling Pathways Induced by Mitochondrial Proteostasis Perturbations
Authors: Madrazo Nicole , Khattar Zinia , Powers Evan T. , Rosarda Jessica D. , Wiseman R. Luke 
Published: February 2024

SUMMARYImbalances in mitochondrial proteostasis are associated with pathologic mitochondrial dysfunction implicated in etiologically-diverse diseases. This has led to considerable interest in defining the biological mechanisms responsible for regulating mitochondria in response to mitochondrial stress. Numerous stress responsive signaling pathways have been suggested to regulate mitochondria in response to proteotoxic stress, including the integrated stress response (ISR), the heat shock response (HSR), and the oxidative stress response (OSR). Here, we define the specific stress signaling pathways activated in response to mitochondrial proteostasis stress by monitoring the expression of sets of genes regulated downstream of each of these signaling pathways in published Perturb-seq datasets from K562 cells CRISPRi-depleted of individual mitochondrial proteostasis factors. Interestingly, we find that the ISR is preferentially activated in response to mitochondrial proteostasis stress, with no other pathway showing significant activation. Further expanding this study, we show that broad depletion of mitochondria-localized proteins similarly shows preferential activation of the ISR relative to other stress-responsive signaling pathways. These results both establish our gene set profiling approach as a viable strategy to probe stress responsive signaling pathways induced by perturbations to specific organelles and identify the ISR as the predominant stress-responsive signaling pathway activated in response to mitochondrial proteostasis disruption.
The kinematics and aerodynamics of hinged wing of honeybees during takeoff
Authors: Li Yizhe , Hao Zhanzhou , Yang Biao , Gong Weijie , Yin Bo , Wang Chao , Song Jialei , Yin Ling 
Published: February 2024

AbstractIn this study, we utilize a high-speed camera array to meticulously capture the intricate wing kinematics of honeybees during free voluntary takeoffs. This allows us to investigate the variation in kinematic parameters over time. According to the variation of Euler angles, the takeoff process can be categorized into three stages: initial, adjusting, and stable. Our analysis reveals that honeybees typically execute at least 15 wingbeats before taking off, with wing stroke amplitudes exceeding 100 degrees and wingbeat frequencies ranging from 180 to 260 Hz. Significantly, the hinged wing mechanism, connecting the forewing and hindwing via hamuli, undergoes considerable chordwise deformation during this process, with the angle between the fore- and hind-wings surpassing 50 degrees. Notably, the forewing and hindwing maintain a positive camber throughout the wingbeat cycle during takeoff, contributing to the enhanced thrust generation instead of lift, comparing to the flat wings. The positive camber can be passively formed at beginning and ending of each half stroke, but should be actively maintained around middle half-stroke.This study provides valuable insights for aeronautical engineers in the design of flapping wing micro air vehicles, specifically in the effective implementation of hinged wings inspired by the wing motion of honeybees.
Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies
Authors: Danielson Meggie , Nicolai Chris J. , Vo Thaomy T. , Wolf Natalie , Burke Thomas P. 
Published: February 2024

SummaryBacterial pathogens that invade the eukaryotic cytosol are distinctive tools for fighting cancer, as they preferentially target tumors and can deliver cancer antigens to MHC-I. Cytosolic bacterial pathogens have undergone extensive preclinical development and human clinical trials, yet the molecular mechanisms by which they are detected by innate immunity in tumors is unclear. We report that intratumoral delivery of phylogenetically distinct cytosolic pathogens, includingListeria, Rickettsia,andBurkholderiaspecies, elicited anti-tumor responses in established, poorly immunogenic melanoma and lymphoma in mice. We were surprised to observe that although the bacteria required entry to the cytosol, the anti-tumor responses were largely independent of the cytosolic sensors cGAS/STING and instead required TLR signaling. Combining pathogens with TLR agonists did not enhance anti-tumor efficacy, while combinations with STING agonists elicited profound, synergistic anti-tumor effects with complete responses in >80% of mice after a single dose. Small molecule TLR agonists also synergistically enhanced the anti-tumor activity of STING agonists. The anti-tumor effects were diminished inRag2-deficient mice and upon CD8 T cell depletion. Mice cured from combination therapy developed immunity to cancer rechallenge that was superior to STING agonist monotherapy. Together, these data provide a framework for enhancing the efficacy of microbial cancer therapies and small molecule innate immune agonists, via the co-activation of STING and TLRs.
Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in developing cochlea
Authors: Kim Jihyun , Martinez Edward , Qiu Jingyun , Ni Julie Zhouli , Kwan Kelvin Y. 
Published: February 2024

AbstractThe chromodomain helicase binding protein 4 (CHD4) is an ATP-dependent chromatin remodeler.De-novopathogenic variants ofCHD4cause Sifrim-Hitz-Weiss syndrome (SIHIWES). Patients with SIHIWES show delayed development, intellectual disability, facial dysmorphism, and hearing loss. Many cochlear cell types, including spiral ganglion neurons (SGNs), express CHD4. SGNs are the primary afferent neurons that convey sound information from the cochlea, but the function of CHD4 in SGNs is unknown. We employed the Neurog1(Ngn1) CreERT2Chd4conditional knockout animals to deleteChd4in SGNs. SGNs are classified as type I and type II neurons. SGNs lacking CHD4 showed abnormal fasciculation of type I neurons along with improper pathfinding of type II fibers. CHD4 binding to chromatin from immortalized multipotent otic progenitor-derived neurons was used to identify candidate target genes in SGNs. Gene ontology analysis of CHD4 target genes revealed cellular processes involved in axon guidance, axonal fasciculation, and ephrin receptor signaling pathway. We validated increasedEpha4transcripts in SGNs fromChd4conditional knockout cochleae. The results suggest that CHD4 attenuates the transcription of axon guidance genes to form the stereotypic pattern of SGN peripheral projections. The results implicate epigenetic changes in circuit wiring by modulating axon guidance molecule expression and provide insights into neurodevelopmental diseases.
Comprehensive genome annotation of the model ciliateTetrahymena thermophilaby in-depth epigenetic and transcriptomic profiling
Authors: Ye Fei , Chen Xiao , Ju Aili , Sheng Yalan , Duan Lili , Al-Rasheid Khaled A. S. , Stover Naomi A. , Gao Shan 
Published: February 2024

AbstractThe ciliateTetrahymena thermophilais a well-established unicellular model eukaryote, contributing significantly to foundational biological discoveries. Despite its acknowledged importance, currentTetrahymenabiology studies face challenges due to gene annotation inaccuracy, particularly the notable absence of untranslated regions (UTRs). To comprehensively annotate theTetrahymenamacronuclear genome, we collected extensive transcriptomic data spanning various cell stages. To ascertain transcript orientation and transcription start/end sites, we incorporated data of epigenetic marks displaying enrichment towards the 5’ end of gene bodies, including H3 lysine 4 tri-methylation (H3K4me3), H2A.Z, nucleosomes, and N6-methyldeoxyadenine (6mA). Additionally, we integrated Nanopore direct sequencing (DRS), strand-specific RNA-seq, and ATAC-seq data. Using a newly-developed bioinformatic pipeline, coupled with manual curation and experimental validation, our work yielded substantial improvements to the current gene models, including the addition of 2,481 new genes, updates to 6,257 existing genes, and the incorporation of 5,917 alternatively spliced isoforms. Furthermore, novel UTR information was annotated for 26,223 high-confidence genes. Intriguingly, 16% of protein-coding genes were identified to have natural antisense transcripts (NATs) characterized by high diversity in alternative splicing, thus offering insights into understanding transcriptional regulation. Our work will enhance the utility ofTetrahymenaas a robust genetic toolkit for advancing biological research.
Er-driven incommensurate to commensurate magnetic phase transition of Fe in the spin-chain compound
BaErFeO4
Authors: Dönni Andreas , Pomjakushin Vladimir Y. , Belik Alexei A. 
Published: February 2024

Magnetic phase transitions and structures of the spin-chain compound BaErFeO4 were investigated by measurements of magnetic properties (specific heat, magnetic susceptibility) and neutron diffraction. The lattice geometry of the orthorhombic crystal structure (space group ) of the BaRFeO4 compounds (R=Dy–Yb, Y) supports frustrations which lead to multiple magnetic phase transitions with complex magnetic structures. BaErFeO4 undergoes three successive magnetic phase transitions at TN1=49K, TN2=33.4K, and TN3=3.4K. In contrast with the previously investigated BaRFeO4 (R=Y, Tm, Yb) compounds, all with incommensurate magnetic propagation vectors k1=(0,0,kz), BaErFeO4 is the first member in this series that shows a phase transition from an incommensurate (k1 below TN1) to a commensurate magnetic structure with k2=(12,0,12) below TN2. In the crystal structure, all magnetic ions (Fe1, Fe2, Er1, and Er2) are part of chains propagating along the b axis. Below TN1, strong antiferromagnetic (AFM) Fe-Fe spin-exchange coupling between square pyramidal (Fe1) and octahedral (Fe2) centers generates a collinear AFM structure with a constant size of the ordered Fe moments and a constant magnetic phase inside each chain of Fe3+ cations. Exchange coupling between the Fe chains is much weaker. At TN2, 3d−4f exchange interactions induce an ordered moment at the Er3+ ions, which results in a change of the direction of the ordered Fe moments from the b direction (above TN2) to inside the ac plane (below TN2) and a change from an incommensurate (k1 above TN2) to a commensurate (k2 below TN2) AFM structure. Toward lower temperature, 4f−4f exchange interactions become stronger and create at TN3 a constant magnetic phase inside each chain of Er3+ cations. At TN2 and TN3, the magnetic susceptibility shows sharp decreases that coincide with large increases of the correlation length of the magnetic structure. The unique magnetic structures of BaErFeO4 are compared with those of other BaRFeO4 compounds by considering experimental and theoretical aspects.

©2024 American Physical Society
2024
American Physical Society
Study on numerical calculation method of corrosion mechanism for Co-12 laser cladding layer
Authors: Deng Shuangjiu , Li Chang , Han Xing , Yu Menghui , Sun Han 
Published: February 2024

Purpose
The restoration and strengthening of QT600 is an industry bottleneck challenge. The Co-12 cladding layer has great wear and corrosion resistance. The purpose of this paper is to quantitatively reveal the transient evolution law of the corrosion process of Co-12 cladding layer on QT600 surface.

Design/methodology/approach
In this paper, a three-dimensional numerical model of the corrosion process of Co-12 cladding layer by QT600 laser cladding is established. The interaction between pitting pits and corrosion medium is considered to reveal the transient evolution of ion concentration, electrode potential, pH and corrosion rate at different locations.

Findings
The calculation shows that the ion concentration in pitting pit changes Cl−>Co2+>Na+, pH value decreases from top to bottom and corrosion rate at bottom is greater than that at top. The electrochemical corrosion test of Co-12 cladding layer was carried out. It is shown that the current density of QT600 increases by an order of magnitude compared to the Co-12 cladding layer, and the corrosion rate is 4.862 times higher than that of the cladding layer.

Originality/value
The results show that Co-12 cladding layer has great corrosion resistance, which provides an effective way for QT600 protection.
Quick-commerce: green initiatives on customer brand engagement
Authors: Lavuri Rambabu , Kokatnur Shilpa , Thaichon Park 
Published: February 2024

PurposeThe study examines quick-commerce (Q-commerce) green initiatives' (GI') impact on consumer brand engagement by mediating [perceived value (PV) and environmental concern (EC)] and moderating (brand attitude).Design/methodology/approachThe study gathered 458 surveys from recent Q-commerce shoppers, employing measurement and structural models alongside the PROCESS macro for data analysis.FindingsThe findings of the study indicate that (1) Q-commerce GI significantly affect PV, EC and directly impact customer brand engagement (CBE). The mediation analysis reveals that (2) PV positively influences EC and CBE; (3) EC has a favorable impact on CBE and (4) CBE positively affects brand attachment (Batta) and green-word of mouth (GWOM).Originality/valueThis study contributes to a deeper understanding of how Q-commerce's GI shape consumer brand engagement behavior. The insights provided can guide Q-commerce players and policymakers in the development and implementation of effective green practices.
Building meanings through annual reports
Authors: Oliveira Lídia , Caria Ana , Gomes Patrícia 
Published: February 2024

PurposeThe paper aims to understand why and how paratextual elements are included in annual reports, hence how meaning is made through the workings of language and imagery.Design/methodology/approachA comprehensive framework of analysis, combining Genette’s paratextual elements with Barthes’ rhetoric and denotation and connotation concepts, is applied to the case study of the dstgroup, a Portuguese engineering and construction group.FindingsThe study demonstrates the potential of the annual report as a communication tool between an organisation and its stakeholders. The framework of analysis evidences that the paratextual elements highlight and supplement accounting information and that the denotative and connotative meanings associated with them make visible and enhance intangible features of the organisation.Originality/valueThe paper extends theories from other interdisciplinary fields to accounting communication and proposes a comprehensive framework that combines the writings of Genette and Barthes. By exploring the Portuguese under-researched context, it also adds to the literature by analysing the rationales and choices of the preparers on the inclusion of paratextual elements in annual reports.