bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical activity, sports participation and school exclusion: An analysis of the millennium cohort study
Authors: Brinkley A. J. 
Published: February 2024

AbstractBackgroundPhysical activity and modes of sport are widely adopted to promote health, wellbeing, behavioural outcomes and educational attainment in young people excluded from education. However, little is known about the physical activity or sports involvement of excluded young people or the role of participation on predictors and outcomes associated with exclusion.AimsThe study aimed to understand (i) how active excluded young people are, (ii) whether predictors of school exclusion are influenced by participation in physical activity or sport and (iii) if physical activity or sports participation moderates the relationship between school exclusion and health, behavioural and educational outcomes.MethodsMillennium Cohort Study Wave 6 data were analysed using linear multiple regression models. Participants were 11,066 young people. Dependent variables were physical activity or sports participation. Independent variables included school exclusion, body composition and physical health, cognitive and educational outcomes, crime, anti‐social and harmful behaviours, mental health and individual demographic predictors.ResultsMultiple regression analysis of Millennium Cohort Study Wave 6 data indicates young people excluded from education participate in more (+20.71 ± 9.72, p = .03) minutes of physical activity but less (−22.38 ± 32.52, p = .49) minutes of sport than non‐excluded participants. Physical activity or sport did not influence predictors or outcomes associated with exclusion.ConclusionFindings indicate young people excluded from education participate in 8% more MVPA, but 13% less sport than peers not excluded from education. These findings highlight concerns related to the provision of school sports and physical education opportunities for young people excluded from education. Moreover, these findings question the role of physical activity or sport as a silver bullet within UK educational policy.
Transient receptor potential vanilloid 1 inhibition reduces brain damage by suppressing neuronal apoptosis after intracerebral hemorrhage
Authors: Chen Chien‐Cheng , Ke Chia‐Hua , Wu Chun‐Hu , Lee Hung‐Fu , Chao Yuan , Tsai Min‐Chien , Shyue Song‐Kun , Chen Szu‐Fu 
Published: February 2024

AbstractIntracerebral hemorrhage (ICH) induces a complex sequence of apoptotic cascades and inflammatory responses, leading to neurological impairment. Transient receptor potential vanilloid 1 (TRPV1), a nonselective cation channel with high calcium permeability, has been implicated in neuronal apoptosis and inflammatory responses. This study used a mouse ICH model and neuronal cultures to examine whether TRPV1 activation exacerbates brain damage and neurological deficits by promoting neuronal apoptosis and neuroinflammation. ICH was induced by injecting collagenase in both wild‐type (WT) C57BL/6 mice and TRPV1−/− mice. Capsaicin (CAP; a TRPV1 agonist) or capsazepine (a TRPV1 antagonist) was administered by intracerebroventricular injection 30 min before ICH induction in WT mice. The effects of genetic deletion or pharmacological inhibition of TRPV1 using CAP or capsazepine on motor deficits, histological damage, apoptotic responses, blood–brain barrier (BBB) permeability, and neuroinflammatory reactions were explored. The antiapoptotic mechanisms and calcium influx induced by TRPV1 inactivation were investigated in cultured hemin‐stimulated neurons. TRPV1 expression was upregulated in the hemorrhagic brain, and TRPV1 was expressed in neurons, microglia, and astrocytes after ICH. Genetic deletion of TRPV1 significantly attenuated motor deficits and brain atrophy for up to 28 days. Deletion of TRPV1 also reduced brain damage, neurodegeneration, microglial activation, cytokine expression, and cell apoptosis at 1 day post‐ICH. Similarly, the administration of CAP ameliorated brain damage, neurodegeneration, brain edema, BBB permeability, and cytokine expression at 1 day post‐ICH. In primary neuronal cultures, pharmacological inactivation of TRPV1 by CAP attenuated neuronal vulnerability to hemin‐induced injury, suppressed apoptosis, and preserved mitochondrial integrity in vitro. Mechanistically, CAP reduced hemin‐stimulated calcium influx and prevented the phosphorylation of CaMKII in cultured neurons, which was associated with reduced activation of P38 and c‐Jun NH2‐terminal kinase mitogen‐activated protein kinase signaling. Our results suggest that TRPV1 inhibition may be a potential therapy for ICH by suppressing mitochondria‐related neuronal apoptosis.
Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine
Authors: Bao Ying , Zhang Dejing , Guo Huihui , Ma Wenxue 
Published: February 2024

AbstractLiquid biopsy is emerging as a pivotal tool in precision oncology, offering a noninvasive and comprehensive approach to cancer diagnostics and management. By harnessing biofluids such as blood, urine, saliva, cerebrospinal fluid, and pleural effusions, this technique profiles key biomarkers including circulating tumor DNA, circulating tumor cells, microRNAs, and extracellular vesicles. This review discusses the extended scope of liquid biopsy, highlighting its indispensable role in enhancing patient outcomes through early detection, continuous monitoring, and tailored therapy. While the advantages are notable, we also address the challenges, emphasizing the necessity for precision, cost‐effectiveness, and standardized methodologies in its broader application. The future trajectory of liquid biopsy is set to expand its reach in personalized medicine, fueled by technological advancements and collaborative research.
Questionnaire survey on public awareness of cleft lip with/without palate in Mongolia
Authors: Gantugs Anar‐Erdene , Imura Hideto , Chimedtseren Ichinnorov , Kitagawa Ken , Sakuma Chisato , Natsume Nagana , Kawana Takayuki , Badamnyambuu Byambajargal , Kurose Motohiro , Niimi Teruyuki , Furukawa Hiroo , Natsume Nagato 
Published: February 2024

AbstractThe frequency of cleft lip with/without palate (CL/P) in the Mongolian population is approximately 1 in 1314 live births. This research aims to disseminate information about this congenital disability to the public to better understand CL/P, and people's fissures, and review administrative measures, as there is a lack of research in this area. A questionnaire survey was conducted using Google Forms, with 1000 Mongolian participants. Most participants (86.7%) said they had knowledge of the word, whereas 86.2% said they had knowledge of the condition. Most participants' answers were question‐related disadvantages of CL/P patients, including statements such as “It's uncomfortable in human relationships” and “It makes an uncomfortable impression on the person you meet the first time.” The results of this study revealed that most Mongolians were aware of CL/P and are concerned about patients. However, the causes of CL/P in the general population remain unknown, and further research is needed in this area.
Contribution of genetic variants in the development of familial premature coronary artery disease in a cohort of cardiac patients
Authors: Mehvari Sepideh , Karimian Fathi Nahid , Saki Sara , Asadnezhad Maryam , Arzhangi Sanaz , Ghodratpour Fatemeh , Mohseni Marzieh , Zare Ashrafi Farzane , Sadeghian Saeed , Boroumand Mohammadali , Shokohizadeh Fatemeh , Rostami Elham , Boroumand Rahnama , Najafipour Reza , Malekzadeh Reza , Riazalhosseini Yasser , Akbari Mohammadreza , Lathrop Mark , Najmabadi Hossein , Hosseini Kaveh , Kahrizi Kimia 
Published: February 2024

AbstractCoronary artery disease (CAD), the most prevalent cardiovascular disease, is the leading cause of death worldwide. Heritable factors play a significant role in the pathogenesis of CAD. It has been proposed that approximately one‐third of patients with CAD have a positive family history, and individuals with such history are at ~1.5‐fold increased risk of CAD in their lifespans. Accordingly, the long‐recognized familial clustering of CAD is a strong risk factor for this disease. Our study aimed to identify candidate genetic variants contributing to CAD by studying a cohort of 60 large Iranian families with at least two members in different generations afflicted with premature CAD (PCAD), defined as established disease at ≤45 years in men and ≤55 years in women. Exome sequencing was performed for a subset of the affected individuals, followed by prioritization and Sanger sequencing of candidate variants in all available family members. Subsequently, apparently healthy carriers of potential risk variants underwent coronary computed tomography angiography (CCTA), followed by co‐segregation analysis of the combined data. Putative causal variants were identified in seven genes, ABCG8, CD36, CYP27A1, PIK3C2G, RASSF9, RYR2, and ZFYVE21, co‐segregating with familial PCAD in seven unrelated families. Among these, PIK3C2G, RASSF9, and ZFYVE21 are novel candidate CAD susceptibility genes. Our findings indicate that rare variants in genes identified in this study are involved in CAD development.
Fourfolded objects, or toward a philosophy of object‐oriented curation
Authors: Kahambing Jan Gresil S. 
Published: February 2024

AbstractThis paper attempts to contextualize a philosophy of curation that is object‐oriented or toward a “return to the object.” In the museum, three interrelated philosophical problems pervade curation practices that prevent access to the object as it is. Here, the subject‐object relations or idealism‐realism issues are reconsidered as a specific niche of the philosophy of curation. To address these issues, this paper claims that Jean‐Paul Martinon and Graham Harman's philosophical return to the Heideggerian fourfold (das Geviert) can introduce creative pathways for the curated object that is riddled with excess and tensions. Later, with some caveats, the paper addresses the issues and suggests a possible avenue for further research.
Molecular testing in salivary gland cytopathology: A practical overview in conjunction with the Milan system
Authors: Carillo Anna Maria , De Luca Caterina , Pisapia Pasquale , Vigliar Elena , Ikenberg Kristian , Freiberger Sandra N. , Troncone Giancarlo , Rupp Niels J. , Bellevicine Claudio 
Published: February 2024

AbstractRecently, significant advances in the molecular characterization of salivary gland neoplasms have facilitated the classification and diagnosis of specific diagnostic entities. In the highly challenging diagnostic scenario of salivary malignancies, molecular testing is increasingly being adopted in routine practice to refine the cytological diagnosis of salivary lesions. Here, we reviewed the most recent evidence in the field of salivary glands molecular cytopathology.
Patient journey and disease‐related digital media usage: A cross‐sectional study among dermatology patients across Germany
Authors: Wecker Hannah , Höllerl Lea , Schick Teresa Sophie , Biedermann Tilo , Zink Alexander , Ziehfreund Stefanie 
Published: February 2024

SummaryBackground and ObjectivesThis study aimed to fill the gap of evidence‐based data by examining the impact of health‐related digital media use's impact on the patient‐physician relationship and patient journey, with the goal of driving positive changes in office‐based dermatological practice.Patients and MethodsGerman individuals with skin conditions completed a questionnaire assessing health‐related digital media use, eHealth literacy, impact of digital media use on the patient‐physician relationship and patient journey, and sociodemographic and health characteristics from June to November 2022, followed by descriptive analysis and linear regressions.ResultsOverall, 919 participants were analyzed (median age: 47.00, interquartile range [28.00; 61.00] years, female: 53.6%, health‐related digital media users: 56.8%). Google and online encyclopedias were commonly used before and after dermatological consultations. Online self‐help groups were used by 75% of non‐treated participants. Digital media use had no impact on the patient‐physician relationship and a positive impact on the patient journey. Positive impacts were associated with higher eHealth literacy, satisfaction with digital media quality, importance of digital media, rural residence, high education, and trust in dermatologists.ConclusionsThe potential of health‐related digital media in office‐based dermatological care necessitates the drive of an evidence‐based digital health platform to improve eHealth literacy and satisfaction with the quality of digital media among affected individuals.
Assessment of functioning in ADHD according to World Health Organization standards: First revision of the International Classification of Functioning, Disability and Health Core Sets
Authors: Bölte Sven , Alehagen Lovisa , Black Melissa H. , Hasslinger John , Wessman Elina , Remnélius Karl Lundin , Marschik Peter B. , D'arcy Emily , Seidel Andreas , Girdler Sonya , Zander Eric 
Published: February 2024

AbstractAimTo conduct the first revision of the World Health Organization International Classification of Functioning, Disability and Health (ICF) Core Sets for attention‐deficit/hyperactivity disorder (ADHD).MethodA Delphi‐like method was used, integrating evidence from stakeholder feedback and developing and piloting the ADHD ICF Core Set platform to inform revisions to the ADHD Core Sets.ResultsA total of 27 second‐level ICF codes were added to the comprehensive ADHD Core Set: body functions of temperament and personality, and basic sensory functions; activities and participation in terms of learning to read and write, spoken communication, community life, religion and spirituality, education, economy, and human rights; environmental factors for domestic animals; and several societal services. The revised comprehensive Core Set contains 98 ICF codes: 18 body function codes; 47 activities and participation codes; and 33 environmental factor codes. Extensive changes were also made to the age‐appropriate brief Core Sets to allow their independent use in research and clinical practice.InterpretationAlthough substantially expanded, the revised ICF Core Sets better reflect the lived experience of individuals with ADHD and clinical implementation preferences than the initial sets. We recommend further feasibility and validation studies of these Core Sets with the goal of optimizing their acceptance and practicability, and strengthening their evidence base.
An estimate of the need for continuous glucose monitoring in type 2 diabetes with intensive insulin treatment in secondary healthcare
Authors: Trolle Christian , Christensen Mia , Hansen Klavs Würgler 
Published: February 2024

AbstractAimTo estimate the proportion of persons with type 2 diabetes (T2DM) receiving intensive insulin treatment in the secondary healthcare who could be candidates for continuous glucose monitoring (CGM), based on different HbA1c criteria. For comparison, the results are also presented as proportion of persons with type 1 diabetes (T1DM) in the same region.Patients and MethodsIn the Central Denmark Region, we identified all persons with T1DM (n = 6179) and T2DM (n = 4315) who had a minimum of one contact to a diabetes outpatient clinic from September 2021 to September 2022. Insulin regimen and HbA1c measured after a minimum of 2 months with a stable insulin regimen were retrieved from the healthcare administrative electronic platform used in the region.ResultsThe numbers of persons with T1DM and T2DM with HbA1c meeting the criteria were 5145 and 3090, respectively. The fraction of T2DM with basal‐bolus insulin was 35.3%, and the fraction with basal‐bolus insulin and HbA1c >53 (7%) mmol/mol or >58 (7.5%) mmol/mol was 20.5% and 16.6%, respectively. These proportions correspond to 19.4%, 14.4% and 11.7% of the persons with T1DM in the same geographical area.ConclusionThe proportion of persons with T2DM in secondary healthcare undergoing intensive insulin treatment who could be candidates for CGM corresponded to only a minor fraction of persons with T1DM in the same region, irrespective of any HbA1c criteria applied.
Collection of cardiac masses. Up‐to‐date echocardiography and cardiac MRI tools
Authors: Baltodano‐Arellano Roberto , Falcón‐Quispe Luis , Cupe‐Chacalcaje Kelly , Meléndez‐Ramírez Gabriela , Cachicatari‐Beltran Angela , Patrón‐Chi Sergio , Benites‐Yshpilco Lindsay , Meave‐González Aloha , Anicama‐Lima William , Becerra Silvia Jiménez , Urdanivia‐Ruiz Dante , Arias‐Godínez José Antonio , Rojas Paol , Moscoso Josh , Levano‐Pachas Gerald 
Published: February 2024

AbstractHeart masses, including tumors (primary and secondary) and pseudotumor (cysts and thrombus), are rare entities, but of increasing interest in cardiac imaging areas. The clinical manifestations are related to the intracardiac effect of mass, embolization, and systemic symptoms in the case of tumors; however, some of them are detected incidentally. Nowadays, imaging techniques and the advancement of their tools perform the morphological, functional, and tissue characterization of the masses, and additionally know the anatomical relationships, which are crucial factors for the treatment and surgical planning.
Functional response of larval and adult Coccinella septempunctata to eggs and larvae of Plutella xylostella on canola
Authors: Kulkarni S. S. , Evenden M. L. 
Published: February 2024

AbstractUnderstanding of functional responses (i.e., changes in predator feeding rates with prey density) of key predators to different crop pest stages is critical to strengthening biological control, particularly in view of climate change and temperature variation. We investigated prey preferences of Coccinella septempunctata L. (Coleoptera: Coccinelidae) to egg and larval stages of a key brassicaceous pest of canola (Brassica napus L., Brassicaceae), the diamondback moth, Plutella xylostella L. (Lepidoptera: Plutellidae). First, laboratory choice and no‐choice bioassays tested the hypotheses that C. septempunctata accepts and differentially prefers two prey developmental stages (eggs and larvae). Then, C. septempunctata larvae and adults were exposed to six densities of P. xylostella eggs over 24 h in functional response bioassays that determined the number of eggs consumed. Finally, the functional response bioassays were repeated with larval prey and extended with three temperature regimes: 10, 22 and 32 °C. In both choice and no‐choice assays, C. septempunctata adults and larvae consumed more P. xylostella larvae than eggs. The functional response of C. septempunctata depended on predator developmental stage and temperature, with reduced handling time and increased attack rates and consumption under warmer conditions. At 10 and 22 °C, the functional responses of both C. septempunctata larvae and adults were of Type II, i.e., rates of prey consumption increase at decelerating rates and then plateau with increasing prey density. Our study demonstrates that both larvae and adults of C. septempunctata can consume high numbers of eggs and early instar P. xylostella larvae; these responses are temperature‐dependent with increased consumption rates at higher temperatures. This may lead to improvements in management of P. xylostella in canola.
Effects of glyphosate and glyphosate‐based herbicide on learning and memory of the buff‐tailed bumblebee (Bombus terrestris)
Authors: Kaakinen Kimmo , Ramula Satu , Loukola Olli J. , Helander Marjo 
Published: February 2024

AbstractThe decline of insect pollinators is a global concern, and the use of pesticides has been identified as a potential cause for it. Glyphosate‐based herbicides (GBHs) are the world's most used pesticides, but until recent years they have been claimed to be safe for non‐target organisms, such as pollinators. Using controlled arena experiments, we investigated the effects on the learning and long‐term memory of buff‐tailed bumblebees,Bombus terrestris(L.) (Hymenoptera: Apidae), of a single field‐realistic dose of glyphosate, both in its pure form and as a commercial herbicide (Roundup Gold) containing the active ingredient (a.i.) glyphosate and other co‐formulants. We found that glyphosate in its pure form caused deterioration in the learning ability of bumblebees in a 10‐color discrimination experiment; the glyphosate‐treated bees discriminated colors over 10% worse than the untreated control bees. However, the commercially used GBH (Roundup Gold) had no observable effect on the learning ability of the bumblebees, despite the fact that this herbicide contained the same amount of glyphosate as its pure form. These findings shed light on the potential risks associated with agrochemicals previously considered safe for pollinators and emphasize the need for comprehensive risk assessments of pesticides, including evaluations of cognitive functions in pollinators. Therefore, we propose that future pesticide testing should incorporate broader assessments to ensure the safety of pollinators in agricultural landscapes.
Association between dysphagia and symptoms of depression and anxiety after ischemic stroke
Authors: Karisik Anel , Dejakum Benjamin , Moelgg Kurt , Komarek Silvia , Toell Thomas , Mayer‐Suess Lukas , Pechlaner Raimund , Kostner Stefanie , Sollereder Simon , Kiechl Sophia , Rossi Sonja , Schoenherr Gudrun , Lang Wilfried , Kiechl Stefan , Knoflach Michael , Boehme Christian ,   for the STROKE‐CARD Registry study group
Published: February 2024

AbstractBackground and purposeDysphagia is associated with poor outcome, higher mortality, reduced quality of life, and social isolation. We investigate the relationship between swallowing impairment and symptoms of anxiety and depression after ischemic stroke.MethodsConsecutive patients with ischemic stroke participating in the prospective STROKE‐CARD Registry study from 2020 to 2022 were assessed for dysphagia on hospital admission (clinical swallowing assessment) and for persistence until discharge and 3‐month follow‐up (SINGER Independency Index). Anxiety and depression symptoms were recorded using Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS) at 3‐month follow‐up.ResultsOf 648 patients, 19.3% had dysphagia on admission, persisting in 14.8% at discharge and 6.8% at 3‐month follow‐up. With the presence or duration of dysphagia (no dysphagia, dysphagia at baseline, at discharge, at 3 months), score (mean ± SD) increased on the BDI (7.9 ± 6.7, 12.5 ± 8.7, 13.5 ± 9.0, 16.5 ± 10.2), HADS‐D (4.4 ± 3.7, 7.1 ± 4.2, 7.7 ± 4.4, 9.8 ± 4.3), and HADS‐A (4.4 ± 3.5, 5.4 ± 3.6, 6.0 ± 3.6, 7.0 ± 3.6). In linear regression analysis adjusting for age, sex, diabetes, dementia, and either functional disability or stroke severity, BDI and HADS‐D scores were significantly higher in patients with dysphagia across all points in time (admission, discharge, 3‐month follow‐up). An independent association with HADS‐A scores was only evident in patients with persisting dysphagia after 3 months. Patients with dysphagia were more likely to receive antidepressants, antipsychotics, or benzodiazepines at discharge and 3‐month follow‐up.ConclusionsDysphagia after stroke is common and severely affects psychosocial functioning of individuals. Our results highlight swallowing impairment as an independent predictor for poststroke depressive and, to a lesser extent, anxiety symptoms.