bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Like an Emotional Trash Can”: An Interview Study of Bhutanese School Guidance Counselors’ Perceived Challenges and Resources
Authors: Larran Julie , Hein Sascha 
Published: February 2025

Abstract
School counselors are responsible for students’ mental health and their increasingly complex issues. However, little is known about school counseling services in the Kingdom of Bhutan. This study conducted 28 semi-structured interviews with school guidance counselors in Bhutan, 19 online and 9 in-person, to investigate their perceived challenges and resources. The data were analyzed using a phenomenological approach to inquiry and thematic analysis proposed by Braun and Clarke (Qualitative Research in Psychology 3(2):77-101, 2006). The identified challenges and resources were grouped for further analysis according to Martin et al.’s (International Journal for the Advancement of Counselling 37(4):305-318, 2015) model of 11 factors influencing school counseling. The most often mentioned challenges were insufficient resources to cope with rising mental health needs and cultural barriers to the implementation of school guidance counseling, such as stigma and the role of corporal punishment. The most often mentioned resources were the importance of material resources, such as having a separate counseling room within the school, and the importance of support from external professionals, such as clinical counselors. In sum, the results revealed the need for (1) more resources to cope with the mental health needs of students, such as additional training, (2) more organization to systemize stakeholder collaboration and to clarify the school guidance counselors’ roles, (3) more awareness in the general population about school guidance counseling, including overcoming stigma towards mental health issues, and (4) more time for this profession to establish itself in the Kingdom.
The impact of SEC23A on 5-FU chemotherapy sensitivity and its involvement in endoplasmic reticulum stress-induced apoptosis in colorectal cancer
Authors: Su Zhaoran , Liu Menglan , Krohn Mathias , Schwarz Sandra , Linnebacher Michael 
Published: February 2025

Abstract
Background: Colorectal cancer (CRC) represents a significant global health burden, with chemotherapy resistance representing a significant challenge to effective treatment. SEC23A, a core component of the COPII vesicle trafficking system, is of critical importance with regard to protein transport and cellular homeostasis. Nevertheless, its function in CRC progression and chemoresistance remains uncertain. The present study investigates the correlation between SEC23A expression and sensitivity to 5-fluorouracil (5-FU), a widely used chemotherapeutic agent, with particular emphasis on ER stress-induced apoptosis. Methods: A bioinformatic analysis was conducted to evaluate SEC23A expression in CRC and its association with patient prognosis. Chemotherapy sensitivity was predicted using GDSC data and validated experimentally using CRC cell lines with manipulated SEC23A expression. In order to explore the role of SEC23A in acquired drug resistance, patient-derived xenograft (PDX) models and 5-FU-resistant cell lines were employed. Apoptosis assays, cell cycle analysis, and ER stress modulation experiments were performed to elucidate the underlying mechanisms. Results: SEC23A expression was significantly reduced in CRC samples compared to normal tissues. This reduction was linked to a poorer prognosis, including both overall and disease-specific survival. A correlation was observed between low SEC23A expression and increased resistance to 5-FU, as evidenced by both bioinformatic predictions and in vitro experiments. In PDX models, metastatic lesions exhibited decreased SEC23A expression following 5-FU treatment in comparison to primary tumors. Overexpression of SEC23A in 5-FU-resistant cell lines restored sensitivity to the drug and increased apoptosis. Bioinformatic and experimental analyses revealed a robust correlation between SEC23A and ER stress-related apoptotic pathways. Elevated expression of SEC23A was observed to facilitate the accumulation of misfolded proteins in response to 5-FU treatment, which in turn resulted in increased ER stress and apoptosis. Conclusions: SEC23A plays a crucial role in modulating the sensitivity of CRC cells to 5-FU by regulating ER stress-induced apoptosis. Its downregulation contributes to chemoresistance, indicating that SEC23A may serve as a prognostic marker and therapeutic target in CRC. Strategies aimed at upregulating SEC23A or enhancing ER stress may provide new avenues for overcoming chemoresistance and improving treatment outcomes for CRC patients.
Intraductal laser ablation during ductoscopy in patients with pathological nipple discharge
Authors: Makineli Seher , Vriens Menno R. , van Diest Paul J. , Witkamp Arjen J. 
Published: February 2025

Abstract

Background
Ductoscopy is a minimally invasive micro-endoscopic approach for direct visualization and removal of intraductal lesions of the breast. A challenge of ductoscopy is an adequate treatment of intraductal lesions by complete removal to prevent exploratory duct excision surgery. This study aimed to determine the in vivo feasibility of intraductal laser ablation during ductoscopy to remove intraductal lesions in patients suffering from pathological nipple discharge (PND).

Methods
A prospective, single-center diagnostic feasibility trial was conducted between October 2022 and November 2023, enrolling adult women with unilateral PND and no radiological suspicion of malignancy. Intraductal laser ablation was performed after incomplete intraductal biopsy using a Thulium laser.

Results
Duct cannulation and subsequent ductoscopic exploration were successful in 21 patients revealing an intraductal lesion in 13 patients (61.9%). From these 13 patients, 9 patients (69.2%) underwent intraductal laser ablation due to a residual lesion after biopsy. Pathology of the removed intraductal lesions showed a papilloma in eight (88.9%) patients and a papilloma/DCIS combination in one patient (11.1%). Post-procedure, PND stopped in 77.8% of the patients (7/9). Two patients had recurrent PND complaints caused by a residual lesion.

Conclusion
Intraductal laser ablation during ductoscopy in patients with papillary lesions seems to be feasible and safe. The Thulium laser enables ablation of residual lesions and is therefore suitable for an immediate second intervention after ductoscopic removal of intraductal lesions. Further refinement and validation in a follow-up clinical trial are necessary to further assess its therapeutic efficacy.
Family Functioning and Parenting Styles in Adolescents Diagnosed with Trichotillomania
Authors: Okumuş Hande Günal , Kaşak Meryem , Çelik Yusuf Selman , Menderes Ayşe Selma Yenen , Sivri İsranur Yenen , Temeltürk Rahime Duygu , Akdemir Devrim 
Published: February 2025

Abstract
This study aimed to compare the family functioning and parenting styles in adolescents with trichotillomania (TTM) and healthy controls and to assess the relationships between the family functioning, parenting styles, and clinical features of TTM, including the severity of TTM, duration of illness, and concomitant psychiatric symptoms. The study sample consisted of 100 adolescents aged 12–18 years, 50 patients with TTM, and 50 healthy controls. All participants completed a sociodemographic and clinical data form, the Massachusetts General Hospital Hairpulling Scale (MGH-HPS), the Revised Children’s Anxiety and Depression Scale-Child Version (RCADS-CV), the Family Assessment Device (FAD), and the Perceived Parental Attitude Scale (PPAS). Results show that adolescents with TTM reported higher levels of comorbid anxiety and depression symptoms than healthy controls, and 64% of adolescents with TTM had at least one comorbid psychiatric disorder. Parents of adolescents with TTM also reported more significant impairment in the affective responsiveness, problem-solving, and general family functioning subscales of the FAD. Adolescents with TTM endorsed significantly more authoritarian perceptions of both parents on the PPAS. While the severity of hairpulling symptoms showed only a positive and significant relationship with the RCADS-CV total internalizing score, the duration of illness was positively and moderately correlated with the impairment in affective responsiveness, problem-solving, and general family functioning subscales of FAD. Finally, the RCADS-CV total internalizing score and the general functioning subscale of FAD were the most important predictors of TTM. The implications of family functioning and parenting styles, future targets for family-focused approaches in TTM, and study limitations are discussed.
Riparian structural vegetation types exhibit differential responses to local community drivers
Authors: de Simone Leopoldo , Fanfarillo Emanuele , Fiaschi Tiberio , Maccherini Simona , Bonari Gianmaria , Angiolini Claudia 
Published: February 2025

Abstract
Riparian vegetation consists of different Structural Vegetation Types (SVTs): woodland, shrubland, and herbaceous communities. Since each SVT may respond differently to abiotic and biotic drivers, our study aimed to disentangle the independent and shared effects of these drivers on distinct SVTs. Using a stratified random sampling approach, we collected 144 plots in a Mediterranean river of central Italy. We applied RDA and variation partitioning to assess the relative importance of local abiotic (lateral gradient, anthropogenic disturbances, environmental factors) and biotic (alien species) drivers on species richness, Shannon diversity index, and community composition of each SVT. After accounting for spatial autocorrelation, abiotic factors emerged as the main filters shaping riparian community assembly. Additionally, our results showed similar responses in the diversity of woodland and herbaceous SVTs to the independent effects of local drivers. In terms of community composition, only woodlands responded to the effects of environment, lateral gradient, and alien species. Consequently, for conservation purposes, different riparian SVTs should be managed separately, as they may respond differently to local drivers. Finally, the shared effects of certain drivers suggest that management measures addressing only a single group of factors are likely less effective.
Plasticizer modulation of dynamic mechanical properties and dielectric performance in sodium alginate-based biopolymer films
Authors: Kandil Heba , El Desouky Fawzy G. 
Published: February 2025

Abstract
This work focuses on the effects of various plasticizers, such as glycerol (GLY), polyethylene glycol (PEG), and dioctyl phthalate (DOP) at 0%, 25%, and 50% concentrations, on the structure, dynamic mechanical behavior, and relaxation dynamics of charge carriers of sodium alginate (SA) film. The investigation of the structure was conducted using attenuated total reflectance fourier transform infrared (ATR-FTIR) and X-ray diffraction (XRD). The AT-FTIR analysis indicated changes in the OH and C–O bands of plasticized SA films, suggesting potential intermolecular interactions between the SA matrix and the plasticizers. Moreover, XRD revealed that GLY and PEG enhanced the amorphous phase of SA, promoting flexibility, while DOP increased crystallinity. Dynamic mechanical testing revealed that the pristine SA biofilm displayed a high storage modulus (
$$\:E^{\prime}$$
) of 11 GPa at − 50 °C, indicating a stiff structure. The plasticization process with GLY, PEG, and DOP resulted in a decrease in the values to 0.09, 0.1, and 7.11 GPa, respectively, as well as a decrease in the glass transition temperature, which was attributed to weakened polymer chain interactions. The drastic reduction in storage modulus upon plasticization indicates enhanced flexibility. Dielectric measurements revealed significantly higher dielectric constants ranging from 1.65 × 106 to 0.12 × 106 at 0.1 Hz and direct current conductivity at lower frequencies, also decreasing in relaxation time for films plasticized with GLY and PEG linked to increased hydroxyl groups and higher amorphous content. These findings highlight the potential of SA films plasticized with GLY and PEG as advanced materials for electrochemical and conductive polymer electrode applications.
Second-Order, Energy-Stable and Maximum Bound Principle Preserving Schemes for Two-Phase Incompressible Flow
Authors: Li Xiaoli , Liu Hao , Zheng Nan 
Published: February 2025

Abstract
In this paper, we propose several linear fully discrete schemes for the mass-conserved Allen-Cahn-Navier–Stokes equation, based on the generalized stabilized exponential scalar auxiliary variable approach in time and the marker and cell (MAC) scheme in space. It is quite remarkable that our schemes can guarantee second-order accuracy in space provided the maximum bound principle (MBP) is satisfied, whereas most previous work can only possess first-order accuracy in space. We rigorously show that the constructed schemes satisfy the unconditional energy dissipation law and preserve the MBP. Finally, various numerical examples are presented to verify the theoretical results and demonstrate the efficiency of the proposed schemes.
Does a Group CBT-Course for Depressed Youth also Reduce Aggression? Results from a Cluster Randomized Controlled Trial
Authors: Olesen Sunniva , Idsoe Thormod , Keles Serap 
Published: February 2025

Abstract
Aggression and depression are two of the most common forms of psychosocial difficulties in adolescents. High prevalence and disabling effects stress the need for more cost-effective interventions. Studies show that the two difficulties are closely linked regarding comorbidity, risk factors, consequences and theoretical background, making it interesting to investigate whether an intervention targeting one of them could also reduce the other. The aim of this study was therefore to assess the association between aggression and depression and to investigate whether a treatment that has been found effective in reducing depression—“Adolescents coping with depression course” (ACDC), a group-based cognitive behavioural intervention-, could also reduce aggression, either directly, or indirectly via reducing depression. The data came from a randomized control trial, with a pre- post- and follow-up longitudinal design. In total 228 youth participated in the study, of which 133 received the ACDC-intervention and 95 received usual care. Correlation analysis showed that aggression and depression were associated at all time points. Structural equation modelling showed that the intervention did have neither direct nor indirect effect on aggression. Our conclusion is that future CBT interventions with a primary aim to reduce depression might have to design intervention components that are more directly targeted toward aggression if also this potential comorbid difficulty should be addressed. Previous studies have found higher levels of comorbid aggression among depressed boys than girls. Few boys in our sample may thereby have reduced statistical power to detect potential influences on aggression.

Trial Registration: ISRCTN registry ISRCTN19700389. Registered 6 October 2015. Full Protocol: https://doi.org/10.1186/s12888-016-0954-y
Barcoding the Caatinga biome bees: a practical review
Authors: Rodrigues Pedro , Teixeira Cláudia , Guimarães Laura , Ferreira Nuno G. C. 
Published: February 2025

Abstract
Bees play a critical role as pollinators in ecosystem services, contributing significantly to the sexual reproduction and diversity of plants. The Caatinga biome in Brazil, home to around 200 bee species, provides an ideal habitat for these species due to its unique climate conditions. However, this biome faces threats from anthropogenic processes, making it urgent to characterise the local bee populations efficiently. Traditional taxonomic surveys for bee identification are complex due to the lack of suitable keys and expertise required. As a result, molecular barcoding has emerged as a valuable tool, using genome regions to compare and identify bee species. However, little is known about Caatinga bees to develop these molecular tools further. This study addresses this gap, providing an updated list of 262 Caatinga bee species across 86 genera and identifying ~ 40 primer sets to aid in barcoding these species. The findings highlight the ongoing work needed to fully characterise the Caatinga biome’s bee distribution and species or subspecies to support more effective monitoring and conservation efforts.
Energy transfer and localization in a forced cyclic chain of oscillators with vibro-impact nonlinear energy sinks
Authors: Weidemann Tobias , Bergman Lawrence A. , Vakakis Alexander F. , Krack Malte 
Published: February 2025

Abstract
We theoretically investigate the strongly nonlinear dynamics, inter-modal targeted energy transfer and energy localization in an elastically coupled cyclic chain of oscillators with vibro-impact nonlinear energy sinks (VI-NESs) under symmetric harmonic standing or traveling wave forcing. Each identical sector of the chain consists of a single linear oscillator hosting a VI-NES, which is a small mass that is freely placed inside a cavity of the oscillator. We show that the VI-NESs are able to synchronize to the global standing or traveling wave response of the structure in the form of 1:1 resonance captures with the oscillators in each sector. In addition, localized states at higher amplitudes can be found where the VI-NESs synchronize to the motion of their host oscillators in only a subset of all sectors. We derive an analytical model to predict the frequency-amplitude curves of these synchronized solutions and study their local asymptotic stability analytically and their practical stability numerically. We show that the globally synchronized response can experience a modulation instability which gives rise to traveling beat waves. High and practically stable localized amplitudes only arise for sufficiently low excitation wavenumbers and weak inter-sector coupling strengths. However, even the largest practically stable amplitudes show a significant reduction of the vibration level compared to the corresponding linear resonant responses. Hence, a robust high performance of the VI-NESs is observed for all excitation wavenumbers and inter-sector coupling strengths.
Complexity in the interpretation and application of multiple guidelines for thyroid nodules: the need for coordinated recommendations for “small” lesions
Authors: Trimboli Pierpaolo 
Published: February 2025

Abstract
Multiple guidelines for thyroid nodule management have been developed by endocrinologists, often in collaboration with surgeons and radiologists. While there is now a lot of scientific information available to meet the needs of healthcare providers, there is not always uniformity and standardization among recommendations. Consequently, the interpretation and application of guidelines in clinical practice remain somewhat limited. In this context, the management of “small” thyroid nodule warrants full discussion. Looking at treatment guidelines, surgery is the first-line option and the risk of cancer relapse can be assessed only after at least thyroidectomy; in addition, according to guidelines of minimally invasive treatment, thermal ablation may be considered for patients with small classical papillary carcinoma. However, the Thyroid Imaging Reporting And Data Systems do not recommend biopsy in nodules less than 1 cm; and performing biopsy may yield a result that is suspicious or consistent with malignancy without specifying the cancer subtype. With these premises, facing cases of “small” nodule less than 1 cm is challenging. Even if the recommendations of guidelines sound singularly appropriate, they may seem conflicting. Coordinated guidelines are needed.
Friction Coefficient Evolution of Drying Lubricant in the Joints of Beetles by Friction Force Microscopy
Authors: Pichler Cornelia F. , Thelen Richard , van de Kamp Thomas , Hölscher Hendrik 
Published: February 2025

Abstract
Recent studies suggest that the joints of beetles and other insects comprise micro-structured surfaces in combination with lubricants. Here, we utilize friction force microscopy (FFM) to analyse the tribological properties of the femoro-tibial leg joints by the example of Coelorrhina aurata (metallic green flower beetle) and Otiorhynchus sulcatus (black vine weevil). To preserve the original state of the lubricant as well as the microstructures, the FFM measurements were conducted in silicone oil, which satisfies our requirements of transparency, customizable viscosity, absent health risks and lower density compared to the expected density of the lubricant. Microscopic friction was measured on fresh and air-dried samples to stress the change of the lubricant properties over time. Despite the similarity of the two beetle joints, the FFM measurements reveal different frictional properties of the respective lubricants.
Pro-Inflammatory Response to Macrotextured Silicone Implant Wear Debris
Authors: Atkins Dixon J. , Rogers Ann E. , Shaffer Kathryn E. , Moore Ian , Miller Wyatt D. , Morrissey Meghan A. , Pitenis Angela A. 
Published: February 2025

Abstract
Macrotextured silicone breast implants are associated with several complications, ranging from seromas and hematomas to the formation of a rare type of lymphoma, known as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The presence of silicone wear debris has been detected within the peri-implant region and fibrotic capsule and histological analyses reveal inflammatory cells surrounding debris particles. However, it is unclear how these debris particles are generated and released from macrotextured implant surfaces, and whether wear debris generation is related to implant stiffness. In this study, we created an accelerated implant aging model to investigate the formation of silicone wear debris produced from self-mated (“shell-shell”) tribological interactions. We created implant-like silicone elastomers from polydimethylsiloxane (PDMS) using Sylgard 184 base:curing agent (10:1, 12:1, and 16:1) and quantified their mechanical properties (E* = 1141 ± 472, 336 ± 20, and 167 ± 53 kPa, respectively). We created macrotextured PDMS samples using the lost-salt technique and compared their self-mated friction coefficient (< µ > = 4.8 ± 3.2, 4.9 ± 1.8, and 6.0 ± 2.3, respectively) and frictional shear stress (τ = 3.1 ± 1.3, 3.2 ± 1.7, and 2.4 ± 1.4 MPa, respectively) to those of the recalled Allergan Biocell macrotextured implant shell (E* = 299 ± 8 kPa, < µ > = 2.2, and τ = 0.8 ± 0.1). Friction coefficient and frictional shear stress were largely insensitive to variations in elastic modulus for macrotextured PDMS samples and recalled implant shells. The stiffest 10:1 PDMS macrotextured sample and the recalled implant shell both generated similar area fractions of silicone wear debris. However, the recalled implant shell released far more particles (> 10×), mainly within the range of 5 to 20 µm2 in area. Bone marrow-derived macrophages (BMDMs) were treated with several concentrations of tribologically generated silicone wear debris. We observed widespread phagocytosis of wear debris particles and increasing secretion of inflammatory cytokines with increasing concentration of wear debris particles. Our investigation highlights the importance of avoiding macrotextured surfaces and mitigating wear debris generation from silicone implants to reduce chronic inflammation.