bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction of Various Models of Palliative Oncology Care: A Systematic
Review
Authors: Arian Mahdieh , Hajiabadi Fatemeh , Amini Zakiyeh , Oghazian Mohammad Bagher , Valinejadi Ali , Sahebkar Amirhossein 
Published: December 2023

Background:
The aim of this study is to synthesize the existing evidence on various
palliative care (PC) models for cancer patients. This effort seeks to discern which facets of PC
models are suitable for various patient cohorts, elucidate their mechanisms, and clarify the
circumstances in which these models operate.

Methods:
A comprehensive search was performed using MeSH terms related to PC and cancer
across various databases. The Preferred Reporting Items for Systematic Reviews and a
comprehensive evidence map were also applied.

Results:
Thirty-three reviews were published between 2009 and 2023. The conceptual PC
models can be classified broadly into time-based, provider-based, disease-based, nurse-based,
issue-based, system-based, team-based, non-hospice-based, hospital-based, community-based,
telehealth-based, and setting-based models. The study argues that the outcomes of PC encompass
timely symptom management, longitudinal psychosocial support, enhanced communication, and
decision-making. Referral methods to specialized PC services include oncologist-initiated
referral based on clinical judgment alone, via referral criteria, automatic referral at the diagnosis
of advanced cancer, or referral based on symptoms or other triggers.

Conclusion:
The gold standard for selecting a PC model in the context of oncology is a model
that ensures broad availability of early PC for all patients and provides well-timed, scheduled,
and specialized care for patients with the greatest requirement.
In-vitro Augmentation of Mesenchymal Stem Cells by Using Adult Bovine
Serum
Authors: Shehzadi Somia , Javed Maryam , Ullah Asmat , Bilal Waqar Ahmad , Iftikhar Shah Fatima , Ullah Sajjad 
Published: December 2023

Background:
Umbilical cord mesenchymal stem cells (UC-MSCs) are increasingly being
utilized for immune-related disease therapies due to their low immunogenicity. However, the
primary culture of UC-MSCs requires the supplementation of serum in the growth medium, which
has posed a challenge due to ethical issues related to the collection method of the fetal bovine
serum (FBS) that is routinely used in cell culture.

Aim:
In order to address this, the purpose of this research was to assess the effectiveness of adult
bovine serum (ABS) as a different and more affordable source of serum for the in-vitro cultivation
of UC-MSCs. UC-MSCs were isolated from the umbilical cord of Wharton’s jelly of cow immediately
after birth, by digestion with Collagenase type I.

Method:
ABS was collected from fresh bovine sources and heat-inactivated. The morphology of
UC-MSCs was observed under an inverted microscope, and growth patterns, proliferative index,
and doubling time were calculated every two days to compare the efficacy of ABS with FBS. Immunocytochemistry
for specific markers was also conducted on the MSCs.

Result:
The results showed a notable difference in morphology, growth rate, population doubling,
and proliferative index between ABS and FBS.

Conclusion:
Intriguingly, ABS proved to be an effective supplement in the growth medium for expanding
UC-MSCs in vitro, providing a viable alternative to FBS.
A Review on the Neuroanatomy of Bee Brain and Social Behavior
Authors: Nongkhlaw Ridahunlang 
Published: December 2023

Abstract:
At present, there is a growing interest among researchers in studying the structure and function of the bee brain in relation to their cognitive
behavior. The bee brain, despite its small size of approximately 1 million neurons, is known for its ability to facilitate effective communication and
collaboration. Just like humans, the bee brain is also controlled by biogenic amines like dopamine, serotonin and tyramine, octopamine, and
histamine. The honey bees communicate with each other by using a complex language called the “waggle dance”. Despite existing knowledge
about the bee brain's neuroanatomy, there is still a need to understand which specific regions control cognition and social behavior in bees. This
review aims to explore the different major parts of the bee brain and how each part contributes to modulating social behavior.
Tacrolimus Pharmacotherapy: Infectious Complications and Toxicity in
Organ Transplant Recipients; An Updated Review
Authors: Tolou_Ghamari Zahra , Palizban Abbas Ali 
Published: December 2023

Background:
After allogeneic organ transplantation, in order to reduce the risk of rejection, tacrolimus is given. In fact, infection is reported as one of the most common side effects of tacrolimus that
might be associated with graft failure.

Objective:
This study aims to review the association between the occurrence of infections due to toxicity
following the administration of tacrolimus in organ transplant recipients.

Methods:
Scientific literature on the pharmacotherapy of tacrolimus after organ transplantation, infections,
and neurotoxicity were searched using PUBMED.Gov (https://pubmed.ncbi.nlm.nih.gov/), Web of Science,
and Scopus (n=108). All articles were screened, and the data associated with the topic of interest was extracted. The primary outcome was infection and neurotoxicity.

Results:
Total area under the curve exposure, the ratio of parent drug/metabolites of tacrolimus was reported to be correlated with aggressive events such as infection episodes. A trough/dose ratio may demonstrate
the net state of immunosuppression and drug-related events. The most frequent infectious complication of
tacrolimus after organ transplantation was reported as urinary tract infections (UTIs). Virulent strains of
recombinant Listeria monocytogenes, in addition to an increase in bacterial burden in the liver and spleen
tissues, were reported in experimental animal studies. Patient survival was significantly lower in recipients
with UTIs in the first post-transplant month. A higher degree of immunosuppression was associated with
recurrent UTIs and drug-resistant organisms. By inhibiting the cerebral immune system, tacrolimus could
cause neurodegeneration.

Conclusion:
Transplant type, gut dysmotility, acute or chronic condition before transplant surgery, use of
azole, antifungal, hematocrit, tacrolimus methods of detection, the total area under the curve, and duration
of hospital stay could define the risk of infection through the first month of transplant surgery. In addition,
neurological and infectious complications could be associated with the higher amounts of tacrolimus trough
levels (C0). Polypharmacy based on tacrolimus, antiviral, and antifungal drugs, in addition to neurotoxicity,
could increase the risk of opportunistic infections such as cytomegalovirus within the first year of organ
transplantation.
Cognitive Inherent SLR Enabled Survey for Software Defect Prediction
Authors: Mishra Anurag , Sharma Ashish 
Published: December 2023

Introduction::
Any software is created to help automate manual processes most of the
time. It is expected from the developed software that it should perform the tasks it is supposed to do.

Methods::
More formally, it should work in a deterministic manner. Further, it should be capable of
knowing if any provided input is not in the required format. Correctness of the software is inherent
virtue that it should possess. Any remaining bug during the development phase would hamper the
application's correctness and impact the software's quality assurance. Software defect prediction is
the research area that helps the developer to know bug-prone areas of the developed software.

Results::
Datasets are used using data mining, machine learning, and deep learning techniques to
achieve study. A systematic literature survey is presented for the selected studies of software defect
prediction.

Conclusion::
Using a grading mechanism, we calculated each study's grade based on its compliance
with the research validation question. After every level, we have selected 54 studies to include in
this study.
Immunization against COVID-19: A Comprehensive Review on the
Leading Vaccines
Authors: Srinivasan Ananyaa , Rajesh Vijaishree , Thamilvanan Dharani , Ganesh Sanjeev Keekan , Chandrasekaran Subathra Devi. 
Published: December 2023

Abstract:
The global impact of coronavirus disease (COVID-19) has prompted researchers and scientists
to develop effective vaccines to contain the spread of the pandemic. This has led to the deployment
of a range of vaccines from different pharmaceutical companies across the globe in a very
short span of time. The current article provides a comprehensive record of all the vaccines developed
against coronavirus with a specific focus on the mode of action and administration of the vaccines.
The article also dwells on the composition, possible side effects and criteria for the choice of individuals
for the administration of the vaccines. Vaccines against COVID-19 have been broadly categorized
as mRNA vaccines, adenoviral vector-based vaccines and inactivated vaccines. Among the
mRNA vaccines, the Pfizer vaccine and Moderna vaccines gained significant popularity. The Oxford
Astro Zeneca vaccine and Sputnik V were the most effective viral vector vaccines. Inactivated vaccines
such as Covaxin and Sinovac were also significant contributions to contain the pandemic. The
review discusses the efficiency of vaccines against the variants of SARS CoV2. The review will
provide a clear-cut idea about all kinds of exciting vaccines against COVID-19. At present, where
the immediate crisis of the pandemic has been successfully contained, this article acts as a resource
for future public health endeavors, policy makers, health care professionals and the general public to
understand the diversity of COVID-19 vaccines.
Migrants as a resource of the precariat
Authors: Kolinko Maryna 
Published: December 2023

The article is devoted to new socio-economic processes in the construction of labor relations and the formation of the workforce, as well as the socio-cultural and political consequences of these transformations. The precariat is considered as a socio-economic phenomenon, which objectively arises against the background of uncertainty and rapid changes of the modern era. The author focuses on the study of social characteristics and risks of the precariat. This particularly concerns migrants who join the ranks of a new social layer.
The relationship between social anomie and the transgressive state of migrants and other fractions of the precariat is clarified. The influence of objective global processes and the situationality of everyday life on the active integration of new forms of employment into the socio-economic space is shown. It has been proven that solidarity is an effective strategy for adapting a person to the conditions of uncertainty in the life of migrants and the risks of the precariat way of being.
The degree of ischemia-reperfusion as a possible risk factor for the development of atrial fibrillation in patients with obstructive sleep apnea syndrome
Authors: Vasiukova A. A. , Kalinkin A. L. 
Published: December 2023

Objective: the purpose of this study was to identify possible factors for the occurrence of atrial fibrillation (AF) in patients with obstructive sleep apnea syndrome (OSA). Materials and methods: the retrospective study included 50 patients (38 men and 12 women, average age 53 (13) years) admitted to Sleep Medicine Center of University clinic of Lomonosov State University with complaints of snoring and stop of breathig during sleep and who underwent a polysomnographic study. The study included only patients with moderate and severe OSA. For all patients included in the study, the presence of comorbidities was assessed: arterial hypertension (HTN), type 2 diabetes mellitus (DM), coronary heart disease (CHD) and restless legs syndrome (RLS). Results: 11 patients had a history of atrial fibrillation and/or during polysomnography. When assessing heart rhythm during a polysomnographic study, 5 patients (10%) had AF, of which 1 patient had not previously reported the presence of arrhythmia. A predictive model was developed to estimate the probability of AF (atrium fibrillation) conditioning on age, average desaturation, % using binary logistic regression. The resulting regression model is statistically significant (p < 0.001). Based on the value of Nagelkerke R², the model explains 50.6% of the observed AF variance. 1 increase of age is associated with 1.211 times increase in AF odds. 1 increase of average desaturation, % is associated with 1.448 times increase in AF odds. Conclusions: it was shown for the first time that, along with such a well-known risk factor for AF as age, parameters of respiratory disorders during sleep, namely, average desaturation, can play a role in the development of AF through the mechanisms of myocardial ischemia-reperfusion. Average desaturation, reflecting the degree of ischemia-reperfusion, may become a risk factor for the development of AF.
A Deep Learning–Based Approach for Prediction of Vancomycin Treatment Monitoring: Retrospective Study Among Patients With Critical Illness
Authors: Kim Dohyun , Choi Hyun-Soo , Lee DongHoon , Kim Minkyu , Kim Yoon , Han Seon-Sook , Heo Yeonjeong , Park Ju-Hee , Park Jinkyeong 
Published: December 2023

Background
Vancomycin pharmacokinetics are highly variable in patients with critical illnesses, and clinicians commonly use population pharmacokinetic (PPK) models based on a Bayesian approach to dose. However, these models are population-dependent, may only sometimes meet the needs of individual patients, and are only used by experienced clinicians as a reference for making treatment decisions. To assist real-world clinicians, we developed a deep learning–based decision-making system that predicts vancomycin therapeutic drug monitoring (TDM) levels in patients in intensive care unit.

Objective
This study aimed to establish joint multilayer perceptron (JointMLP), a new deep-learning model for predicting vancomycin TDM levels, and compare its performance with the PPK models, extreme gradient boosting (XGBoost), and TabNet.

Methods
We used a 977-case data set split into training and testing groups in a 9:1 ratio. We performed external validation of the model using 1429 cases from Kangwon National University Hospital and 2394 cases from the Medical Information Mart for Intensive Care–IV (MIMIC-IV). In addition, we performed 10-fold cross-validation on the internal training data set and calculated the 95% CIs using the metric. Finally, we evaluated the generalization ability of the JointMLP model using the MIMIC-IV data set.

Results
Our JointMLP model outperformed other models in predicting vancomycin TDM levels in internal and external data sets. Compared to PPK, the JointMLP model improved predictive power by up to 31% (mean absolute error [MAE] 6.68 vs 5.11) on the internal data set and 81% (MAE 11.87 vs 6.56) on the external data set. In addition, the JointMLP model significantly outperforms XGBoost and TabNet, with a 13% (MAE 5.75 vs 5.11) and 14% (MAE 5.85 vs 5.11) improvement in predictive accuracy on the inner data set, respectively. On both the internal and external data sets, our JointMLP model performed well compared to XGBoost and TabNet, achieving prediction accuracy improvements of 34% and 14%, respectively. Additionally, our JointMLP model showed higher robustness to outlier data than the other models, as evidenced by its higher root mean squared error performance across all data sets. The mean errors and variances of the JointMLP model were close to zero and smaller than those of the PPK model in internal and external data sets.

Conclusions
Our JointMLP approach can help optimize treatment outcomes in patients with critical illnesses in an intensive care unit setting, reducing side effects associated with suboptimal vancomycin administration. These include increased risk of bacterial resistance, extended hospital stays, and increased health care costs. In addition, the superior performance of our model compared to existing models highlights its potential to help real-world clinicians.
Comparing the Effectiveness of the Blended Delivery Mode With the Face-to-Face Delivery Mode of Smoking Cessation Treatment: Noninferiority Randomized Controlled Trial
Authors: Siemer Lutz , Pieterse Marcel E , Ben Allouch Somaya , Postel Marloes G , Brusse-Keizer Marjolein G J 
Published: December 2023

Background
Tobacco consumption is a leading cause of death and disease, killing >8 million people each year. Smoking cessation significantly reduces the risk of developing smoking-related diseases. Although combined treatment for addiction is promising, evidence of its effectiveness is still emerging. Currently, there is no published research comparing the effectiveness of blended smoking cessation treatments (BSCTs) with face-to-face (F2F) treatments, where web-based components replace 50% of the F2F components in blended treatment.

Objective
The primary objective of this 2-arm noninferiority randomized controlled trial was to determine whether a BSCT is noninferior to an F2F treatment with identical ingredients in achieving abstinence rates.

Methods
This study included 344 individuals who smoke (at least 1 cigarette per day) attending an outpatient smoking cessation clinic in the Netherlands. The participants received either a blended 50% F2F and 50% web-based BSCT or only F2F treatment with similar content and intensity. The primary outcome measure was cotinine-validated abstinence rates from all smoking products at 3 and 15 months after treatment initiation. Additional measures included carbon monoxide–validated point prevalence abstinence; self-reported point prevalence abstinence; and self-reported continuous abstinence rates at 3, 6, 9, and 15 months after treatment initiation.

Results
None of the 13 outcomes showed statistically confirmed noninferiority of the BSCT, whereas 4 outcomes showed significantly (P<.001) inferior abstinence rates of the BSCT: cotinine-validated point prevalence abstinence rate at 3 months (difference 12.7, 95% CI 6.2-19.4), self-reported point prevalence abstinence rate at 6 months (difference 19.3, 95% CI 11.5-27.0) and at 15 months (difference 11.7, 95% CI 5.8-17.9), and self-reported continuous abstinence rate at 6 months (difference 13.8, 95% CI 6.8-20.8). The remaining 9 outcomes, including the cotinine-validated point prevalence abstinence rate at 15 months, were inconclusive.

Conclusions
In this high-intensity outpatient smoking cessation trial, the blended mode was predominantly less effective than the traditional F2F mode. The results contradict the widely assumed potential benefits of blended treatment and suggest that further research is needed to identify the critical factors in the design of blended interventions.

Trial Registration
Netherlands Trial Register 27150; https://onderzoekmetmensen.nl/nl/trial/27150

International Registered Report Identifier (IRRID)
RR2-doi.org/10.1186/s12889-016-3851-x
Direitos .... bem viver, desenvolvimento, espaço urbano e identidade sociopolítica - processos de transformação e produção de vida
Authors: Silva Andreia Rosalina 
Published: December 2023

O presente artigo tem origem em pesquisa de doutorado[1] sobre a presença de Quilombolas na Pós-graduação em quatro universidades públicas do Brasil – duas do Centro-oeste e duas do Nordeste, tendo em vista as considerações de seus interlocutores a respeito da luta por cidadania e afirmação de direitos - ao território, seu bem estar e à cidade/universidade. A partir da discussão sobre concepções como pertencimento, bem viver, cidade cognitiva e educação, o artigo traz à reflexão o contexto urbano marcado por racismos e colonialidades, e onde se faz necessária a ação sociopolítica, para iniciar processos de transformação e produção de vida, em que todos tenham a sensação de pertencer e possam ter uma vida plena e satisfatória. Assim, resgatamos a compreensão do que significa a atuação quilombola dentro das comunidades, cidades e universidades, articulando seus saberes tradicionais com os conhecimentos científicos sistematizados, o se apresenta como um novo caminho para o desenvolvimento humano.
[1] Pesquisa Financiada pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Bolsa Doutorado. 2019-2022.
MEMPERTAUTKAN DUA HATI, DUA NEGARA BANGSA
Authors: Zed Mestika 
Published: December 2023

Judul Buku : Seperti Bulan dan Matahari, Indonesia dalam Catatan Seorang Diplomat Amerika Penulis : Stanley Harsha Pengantar : Azyumardi Azra Penerbit : Kompas, Mei 2015 Kategori : Catatan pengamatan personal tentang sosial, budaya, dan politik, human interests Tebal : 254 halaman Penulis Resensi : Mestika Zed
EDITORIAL
Authors: Syamsir Syamsir 
Published: December 2023

Jurnal TINGKAP Volume XI, No. 1 bulan April 2015 ini menyajikan 6 artikel, yaitu 4 artikel hasil penelitian, 2 artikel teoretik, dan 1 Resensi buku. Tulisan-tulisan tersebut terangkum dalam satu tema: Pendidikan dan Pendidikan Karakter dan meliputi berbagai topik, yaitu: Kontribusi Kepemimpinan Transaksional Kepala Sekolah dan Motivasi Berprestasi Guru Terhadap Profesionalitas Guru SMA Padang Utara (Desi Areva); Kontribusi Iklim Kerja dan Insentif Terhadap Kepuasan Kerja Guru SMK Swasta di Bukittinggi (Dessi Susanti); Peranan Metode Diskusi dalam Pembentukan Karakter Mahasiswa Melalui Mata Kuliah Pendidikan Kewarganegaraan (PKn) (Edi Saputra); Integrasi Nilai-Nilai Kearifan Lokal Minangkabau ke dalam Materi Ajar Sosiologi dalam Pembentukan Karakter Peserta Didik (Erianjoni); Pembentukan Karakter Melalui Pendidikan Sosiologi (Gurniwan Kamil P); dan Model Penilaian Kemampuan Berpikir Historis (Historical Thinking) dengan Model RASCH (Ofianto dan Wahidul Basri). Selain itu Jurnal edisi ini juga dilengkapi dengan satu resensi buku yang ditulis oleh Mestika Zed: Mempertautkan Dua Hati, Dua Negara Bangsa.
PENGARUH PENDEKATAN SAINTIFIK BERBANTUAN MEDIA VIDEO DAN MOTIVASI TERHADAP HASIL BELAJAR MATEMATIKA SISWA KELAS V SEKOLAH DASAR
Authors: Sirait Hotmaida Rotua , Napitupulu Efendi , Darmana Ayi 
Published: December 2023

The aim of this research is to: Examine how fifth grade students at SD Negeri 2, Kualuh Hulu District, learned mathematics using scientific techniques aided by audiovisual technology. People living in Kualuh Hulu Regency's SD Negeri Region 2. The number of schools is 63 schools. The research sample was 60 students of SD Negeri No. 112279 Aek. A sample of 30 students were taught using a scientific learning approach (Experiment/A1) with video assistance, and 30 students were taught using a contextual learning approach (Control/A2) without video assistance. The research instruments are tests and questionnaires to differentiate student motivation. This research uses a 2 x factorial design. The research findings passed the homogeneity and normality tests which are prerequisites for analysis. Hypotheses can be tested using Two Way Analysis of Variance, often known as Two Way Anova. The study concludes that a scientific strategy using video media influences students' learning results in mathematics at SD Negeri Region 2 Kualuh Hulu Regency.