bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bietti’s crystalline dystrophy: genotyping and deep qualitative and quantitative phenotyping in preparation for clinical trials
Authors: Li Qian , Wang Cong , Zhang Shengjuan , Fu Zhongjie , Jiao Xiaodong , Jin Zi-Bing , Hejtmancik James Fielding , Peng Xiaoyan 
Published: November 2023

PurposeTo qualitatively and quantitatively characterise the genotypes and phenotypes of Bietti’s crystalline dystrophy (BCD) in a cohort of patients.DesignCross-sectional and observational study.MethodsClinically confirmed BCD patients were recruited for genotyping and phenotyping. Multiple retinal imaging modalities were employed. Atrophy in the fovea was adopted as major consideration for staging strategy, while percentage area of autofluorescence (AF) atrophy (PAFA) in the macula was determined for quantitation.ResultsIn 74 clinically diagnosed BCD patients, c.802–8_810del17insGC was shown the predominant variant of theCYP4V2gene (allele frequency 55.4%). Sixty-two cases (123 eyes) with full imaging data were classified according to a modified criterion into stages 1 (n=8, 6.50%), 2A (n=9, 7.32%), 2B (n=17, 13.82%), 3A (n=30, 24.39%) and 3B (n=59, 47.97%). The eyes of the stage 2B were particularly deemed ‘high risk’ due to atrophy near fovea, while in stage 3A, though with remarkable foveal atrophy, preserved retinal pigment epithelium/photoreceptor islands near the fovea were found in 14 eyes. A tendency of increase in PAFA with age was found (rs=0.31, p=0.014). Significant PAFA increase was shown through stages 1 to 3B, and best-corrected visual acuity (BCVA, Logarithm of the Minimum Angle of Resolution) was shown to moderately correlate with PAFA (rs=0.56, p<0.001).ConclusionThe PAFA might be an efficient biomarker for BCD severities correlating with BCVA. The highly heterogeneous chorioretinopathy and BCVA of BCD cases appear to be associated with disease stages, progression types and patients’ ages. Foveal involvement should be of a major concern for consideration of potential therapeutic intervention.
Capability and feasibility of the Global Alignment of Immunisation Safety Assessment in pregnancy criteria for the assessment of pregnancy and birth outcomes in Kinshasa, Democratic Republic of the Congo: a prospective cohort study
Authors: Arena Patrick J , Gadoth Adva , Nkamba Dalau Mukadi , Dzogang Camille , Hoff Nicole , Barrall Angelica L , Kampilu David , Beia Michael , Wong Hui-Lee , Anderson Steven , Kaba Didine , Rimoin Anne W 
Published: November 2023

IntroductionThere is an urgent need to investigate the capabilities of active surveillance in strengthening the development of pharmacovigilance (PV) systems in low-resource settings. Here, we assess the capability and feasibility of prospectively collected data to document maternal immunisation and adverse birth outcomes across delivery centres in Kinshasa, Democratic Republic of the Congo (DRC) according to the Global Alignment of Immunisation Safety Assessment in pregnancy (GAIA) definitions.MethodsWe conducted a facility-based prospective cohort study that enrolled mothers via convenience sampling either during their antenatal care visit or following their delivery. Demographic and clinical information as well as postpartum details related to the index pregnancy were collected after delivery; all mothers were also contacted via telephone 30 days postdelivery to determine if certain outcomes occurred after health facility discharge. Adverse birth outcomes of interest and maternal tetanus immunisation were categorised according to the GAIA criteria, and the level and impact of loss to follow-up (LTFU) was also evaluated.ResultsThe study population consisted of 2675 mothers. The proportion of adverse birth outcomes ranged from 1.6% (for neonatal death) to 15.8% (for small for gestational age). Evidence of maternal tetanus immunisation during the index pregnancy was found for 637 mothers of newborns with any adverse birth outcome. GAIA diagnostic certainty was high for low birth weight and preterm birth, but much lower for stillbirth and neonatal bloodstream infections. Additionally, LTFU was high: only 47.9% of all mothers were successfully followed up via phone call.ConclusionOur investigation highlighted some of the challenges associated with the utilisation of the GAIA criteria in (prospective) observational studies within health facilities in Kinshasa, DRC (eg, data quality, LTFU and selection bias). Nevertheless, active surveillance remains a promising tool for future PV activities in DRC and beyond.
Child pedestrian crossing behaviour and associated risk factors in school zones: a video-based observational study in Kampala, Uganda
Authors: Osuret Jimmy , Van Niekerk Ashley , Kobusingye Olive , Atuyambe Lynn , Nankabirwa Victoria 
Published: November 2023

BackgroundPedestrian crashes, often occurring while road crossing and associated with crossing behaviour, make up 34.8% of road casualties in Uganda. This study determined crossing behaviour and associated factors among child pedestrians around primary schools in Kampala, Uganda.MethodsWe conducted a cross-sectional study in 2022 among 2100 primary school children. Data on their crossing behaviour were collected using video recordings from cameras staged at the crossing points of 21 schools. We estimated prevalence ratios (PR) with their corresponding 95% CIs using a modified Poisson regression model for the association between unsafe behaviour and the predictors.ResultsThe prevalence for each of 5 unsafe child pedestrian behaviour was 206 (25.8%) for crossing outside the crosswalk, 415 (19.8%) for failing to wait at the kerb, 238 (11.3%) for failing to look for vehicles, 361 (17.2%) for running and 235 (13%) for crossing between vehicles. There was a higher likelihood of crossing outside the crosswalk when an obstacle was present (adjusted PR (aPR) 1.8; 95% CI 1.40 to 2.27) and when children crossed alone (aPR 1.5; 95% CI 1.13 to 2.06). Children who crossed without a traffic warden (aPR 2; 95% CI 1.40 to 2.37) had a significantly higher prevalence of failing to wait at a kerb.ConclusionThese findings reveal the interaction between child pedestrians, vehicles and the environment at crossings. Some factors associated with unsafe child pedestrian behaviour were the presence of an obstacle, crossing alone and the absence of a traffic warden. These findings can help researchers and practitioners understand child pedestrian crossing behaviour, highlighting the need to prioritise targeted safety measures.
Hamiltonian analysis for new massive gravity
Authors: Escalante Alberto , Ocaña-García P. Fernando 
Published: November 2023

AbstractA detailed canonical analysis for three- dimensional massive gravity is performed. The construction of the fundamental Dirac brackets, the complete structure of the constraints and the counting of the physical degrees of freedom are reported. In addition, it is shown that the extended Hamiltonian is healed from Orstrogradki’s instabilities.
Einstein–Bumblebee-dilaton black hole solution
Authors: Lessa L. A. , Silva J. E. G. 
Published: November 2023

AbstractWe obtain new black hole solutions in a Einstein–Bumblebee-scalar theory. By starting with a Einstein–Bumblebee theory in ($$D+d$$

D
+
d

) dimensions, the scalar dilaton field and its interaction with the gravitational and Bumblebee fields are obtained by Kaluza–Klein (KK) reduction over the extra dimensions. Considering the effects of both the Bumblebee vacuum expectation value (VEV) and the fluctuations over the VEV, we obtained new charged solutions in $$(3+1)$$

(
3
+
1
)

dimensions. For a vanishing dilaton, the black hole turned out to be a charged de Sitter-Reissner–Nordstrom solution, where the transverse mode is the Maxwell field and the longitudinal mode is the cosmological constant. The stability of these new solutions is investigated by means of the analysis of the black hole thermodynamics. The temperature, entropy, and heat capacity show that these modified black holes are thermodynamic stable.
From concrete quarks to QCD: a personal perspective
Authors: Llewellyn Smith Chris 
Published: November 2023

AbstractThe simple story line that ‘Gell-Mann and Zweig invented quarks in 1964 and the quark model was generally accepted after 1968 when deep inelastic electron scattering experiments at SLAC showed that they are real’ contains elements of the truth, but is not true. This paper describes the origins and development of the quark model until it became generally accepted in the mid-1970s, as witnessed by a spectator and some-time participant who joined the field as a graduate student in October 1964. It aims to ensure that the role of Petermann is not overlooked, and Zweig and Bjorken get the recognition they deserve, and to clarify the role of Serber.
A new cave-dwelling hadzioid amphipod (Senticaudata, Hadzioidea, Melitidae) from sulfidic groundwaters in Iran
Authors: Malek-Hosseini Mohammad Javad , Brad Traian , Fatemi Yaser , Kuntner Matjaž , Fišer Cene 
Published: November 2023

Abstract
Cave systems fed with hydrogen sulfide-rich groundwater are unique chemoautotrophy-dependent ecosystems. Although globally widespread and known to harbor unique subterranean metazoan communities, they have mostly been studied in Europe and North America, less so in Asia. Here, we report on a discovery of a new species of amphipod crustacean from sulfidic waters of Tashan-Chah Kabootari aquifer from Zagros Mountains in Iran. The new species corresponds morphologically to the melitid genus Tegano Barnard & Karaman, 1982, and Tegano tashanensis sp. nov. is the first amphipod from the superfamily Hadzioidea found exclusively in sulfidic water. Phylogenies derived from the mitochondrial coi and the nuclear 28S rRNA sequences recover T. tashanensis sp. nov. in a clade that contains representatives of the currently para- or polyphyletic genera Barnardomelita, Brachina, Josephosella, and Tegano indicating the need for a revised melitid genus level systematics. This clade comprises marine, freshwater and subterranean species globally distributed in regions that were connected by the ancient Tethys Sea. As such, these taxa may be suitable biogeographic models for studying past dispersal, vicariance and multiple colonization of inland groundwaters.
Colloquium 1 Gazing at the Sun: Contemplation of the One and Happiness in the Philosophy of Plotinus
Authors: Stróżyński Mateusz 
Published: November 2023

Abstract
The paper explores the link between contemplation of the One and happiness in Plotinus and challenges the traditional interpretation according to which a contemplative or mystical experience of the One is by necessity brief and transitory, while the experience of Intellect can become a stable state in this life. Were it so, it would not serve as a ground for the good or happy life. In order to reconcile this point with Plotinus’s other claim about contemplation, his doctrine of the double activity of Intellect is invoked.
Colloquium 3 Commentary on Hayes
Authors: Pfeiffer Christian 
Published: November 2023

Abstract
In his paper, Josh Hayes argues that inclination (ῥοπή) is the nature of each element. It is an active and passive principle that explains why the elements move to their proper places. Thus, according to Hayes, by introducing inclination in De Caelo IV 1, Aristotle posits a single explanatory factor that accounts for all elemental motions. By doing so, he answers the question, posed in Physics VIII 4, of what the cause of elemental motion is. In my comments, I will contest these claims. Aristotle’s theory of elemental motion does not rely on a single explanatory factor; yet, it is not, as Hayes claims, incoherent. Instead, the different strands merely reflect the special nature of the elements.
Epidemiology and outcomes of emergency department visits in systemic lupus erythematosus: Insights from the nationwide emergency department sample (NEDS)
Authors: Dhital Rashmi , Pokharel Ashbina , Karageorgiou Ioannis , Poudel Dilli R , Guma Monica , Kalunian Kenneth 
Published: November 2023

Background Systemic lupus erythematosus (SLE) patients are prone to frequent emergency department (ED) visits. This study explores the epidemiology and outcomes of ED visits by patients with SLE utilizing the Nationwide Emergency Department Sample (NEDS). Methods Using NEDS (2019), SLE ED visits identified using ICD-10 codes (M32. xx) were compared with non-SLE ED visits in terms of demographic and clinical features and primary diagnoses associated with the ED visits. Factors associated with inpatient admission were analyzed using logistic regression. Variations in ED visits by age and race were assessed. Results We identified 414,139 (0.35%) ED visits for adults ≥ 18 years with SLE. ED visits with SLE comprised more women, Black patients, ages 31–50 years, Medicare as the primary payer, and had higher comorbidity burden. A greater proportion of Black and Hispanic SLE patients who visited the ED were in the youngest age category of 18–30 years (around 20%) compared to White patients (less than 10%). Non-White patients had higher Medicaid utilization (27%–32% vs 19% in White patients). Comorbidity patterns varied based on race, with more White patients having higher rates of hyperlipidemia and ischemic heart disease (IHD) and more Black patients having chronic kidney disease (CKD), hypertension, and heart failure. Categorizing by race, SLE/connective tissue disease (CTD) and infection were the most prevalent primary ED diagnosis in non-White and White patients, respectively. Age ≥ 65 years, male sex, and comorbidities were linked to a higher risk of admission. Black race (OR 0.86, p = .01) and lowest income quartile (OR 0.78, p = .003) had lower odds of inpatient admission. Conclusion Infection and SLE/CTD were among the top diagnoses associated with ED visits and inpatient admission. Despite comprising a significant proportion of SLE ED visits, Black patients had lower odds of admission. While the higher prevalence of older age groups, hyperlipidemia, and IHD among White patients may partly explain the disparate results, and further study is needed to understand the role of other factors including reliance on the ED for routine care compared among Black patients, differences in insurance coverage, and potential socioeconomic biases among healthcare providers.
Acute infusion-related reactions in pediatric patients receiving etoposide at a tertiary cancer center
Authors: McBride Patrick , Degar Barbara 
Published: November 2023

Introduction Etoposide is a key component of many pediatric chemotherapy regimens for both hematologic and solid tumors. It is well documented that patients receiving etoposide may experience infusion-related reactions. Methods In this study, total doses of etoposide and etoposide phosphate were identified, and infusion-related reactions were retrospectively evaluated at a large pediatric oncology ambulatory clinic. The primary outcome was to determine the rate of acute infusion-related reactions to etoposide. A secondary objective was to identify potential risk factors associated with such reactions. Results Overall, 1463 doses of etoposide were dispensed to 150 unique patients and 15 patients (10%) experienced etoposide infusion-related reactions. Of the 15 patients that experienced etoposide infusion-related reaction, two were successfully able to tolerate subsequent infusions with a slower etoposide infusion rate and pre-medications. The remaining patients changed drug formulation to etoposide phosphate ( n = 12) or continued therapy without any formulation of etoposide ( n = 1). Patients with classical Hodgkin's lymphoma experienced a higher incidence of infusion-related reactions compared to the overall patient population (30.5% vs. 10%) and made up 73.3% of all infusion-related reactions during the study period. Conclusions During the examined study period, 10% of patients experienced an acute infusion-related reaction to etoposide. This review builds on previous literature concluding that additional monitoring may be warranted in patients with classical Hodgkin's lymphoma receiving etoposide.
Factors affecting the association between maternal adverse childhood experiences and preschool children’s behavioural problems: a systematic review of mediators and moderators
Authors: Kurbatfinski Stefan , Letourneau Nicole , Dewey Deborah , Hayes Andrew F. , Hayden K. Alix , Anis Lubna , Dosani Aliyah 
Published: November 2023

Background Adverse childhood experiences (ACEs) are pernicious events (e.g., physical abuse) that occur before 18 years of age within the household. Mothers’ ACEs are associated intergenerationally with their preschool children’s (two-to-five-year-old) behavioural problems, impacting lifelong mental health trajectories. Mediators (e.g., mental health) may explain how mothers’ ACEs exert their influence on children's behavioural development whereas moderators (e.g., child sex) may affect the strength and direction of the association, revealing potential points of intervention. Therefore, this study aimed to: (1) identify mediators and moderators of this association; and (2) describe and compare moderation and mediation outcomes. Methods This review (#CRD42022307214) extracted data from peer-reviewed literature formally analyzing at least one moderating or mediating variable of the association between maternal ACEs and preschool children’s behavioural problems using MEDLINE, Embase, APA PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL, SCOPUS, and Web of Science databases (n = 7). Validity was assessed using the Joanna Briggs Institute checklists. Results Thirteen full-text studies with moderate-to-high validity were identified. Most studies examined mediating variables, with unanimous support for mediation through maternal depression. The mediating roles of adult attachment styles and anxiety were conflicting. No studies examined environmental factors (e.g., neurotoxins). Conclusions Mothers’ depression is a significant contributor to children’s behavioural problems in the context of ACEs and should be a target of early intervention to prevent lifelong challenges. Future research should focus on examining more moderating variables and consider the roles of environmental factors. More research is needed on the moderating and mediating roles of genes.
Peptic ulcer disease burden, trends, and inequalities in 204 countries and territories, 1990–2019: a population-based study
Authors: Zhang Zhongmian , Yan Weitian , Zhang Xiyan , Wang Jiaqi , Zhang Zhonghan , Lin Zili , Wang Lan , Chen Jiaqin , Liu Daming , Zhang Wen , Li Zhihong 
Published: November 2023

Background: Peptic ulcer disease has been a major threat to the world’s population, which remains a significant cause of hospitalization worldwide and healthcare resource utilization. Objectives: We aimed to describe the global burden, trends, and inequalities of peptic ulcer disease. Design: An observational study was conducted. Methods: In this secondary analysis of the Global Burden of Disease, Injuries, and Risk Factors Study 2019, we extracted data for age-standardized incidence rates (ASIRs), disability-adjusted life year rates (ASDRs), and mortality rates (ASMRs); then, we stratified by age, level of regionals, and country; subsequently, we calculated estimated annual percentage changes (EAPC) of ASIR, ASDR, ASMR, and quantified cross-country inequalities in peptic ulcer disease mortality. Results: Globally, ASIR showed a continuous downward trend, from 63.84 in 1990 to 44.26 per 100,000 population in 2019, with an annual decrease of 1.42% [EAPC = −1.42 (95% CI: −1.55 to −1.29)]. ASDR showed a continuing downward trend, and the EAPC was −3.47% (−3.58 to −3.37). ASMR showed a persistent decline, declining by nearly half in 2019 compared to 1990 (3.0 versus 7.39 per 100,000 population), with an annual decrease of 2.55% [EAPC = −3.36 (95% CI: −3.47 to −3.25)]. A significant reduction in sociodemographic index (SDI)-related inequality, from an excess of 190.43 disability-adjusted life years (DALY) per 100,000 (95% CI: −190.83 to −190.02) between the poorest and richest countries in 1990 to 62.85 DALY per 100,000 (95% CI −62.81 to −62.35) in 2019. Conclusion: Global peptic ulcer disease morbidity and mortality rates decreased significantly from 1990 to 2019. These health gains were in accordance with a substantial reduction in the magnitude of SDI-related inequalities across countries, which is paired with overall socioeconomic and health improvements observed in the region.
Changes in the physiological activity of parenchyma cells in Dalbergia odorifera xylem and its relationship with heartwood formation
Authors: Ma Ruoke , Luo Jia , Wang Weijie , Fu Yunlin 
Published: November 2023

Abstract
Background
The formation of a tree’s heartwood gives the wood properties such as natural decay resistance and aesthetic color, and often directly determines the value of wood products. Regulating the quantity and quality of heartwood is of great importance to the use of wood. However, the mechanism of heartwood formation has been poorly understood.

Results
Using Dalbergia odorifera as the study species, the number of starch grains, the morphology of the nuclei, the changes in the content of water and secondary metabolites were observed continuously in the radial direction of the xylem. The results show that from the outer toward inner sapwood, the starch grains are abundant, the length to diameter ratio of the nuclei is decreasing, and the morphology changes from elongated elliptical and then to round. In the outer transition zone, the starch grains begin to decrease abruptly and the nuclei shrink at a slower rate, with a radial width of approximately 2 mm. In the inner transition zone, the heartwood color begins to appear, the starch grains disappear and a few nuclei with reduced fluorescence are present, with a radial width of approximately 1 mm. Heartwood formation after complete disappearance of the nuclei. The moisture content of the heartwood is higher than that of the sapwood, and the inner transition zone is where the content rises. The secondary metabolites of the heartwood begin to accumulate in large quantities in the inner transition zone.

Conclusion
Based on the physiological changes of parenchyma cells in the xylem, the radial width of the transition zone of Dalbergia odorifera is clearly defined as approximately 3 mm. Both the water and secondary metabolite abrupt changes occur at the final stage of programmed cell death, and neither is a direct cause of programmed cell death in parenchyma cells.