bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desain Perancangan Teknologi Pulsed Electric Field dalam Reduksi Bakteri Ikan
Authors: Qirom Qirom , Darmawan Arry , Niam Bahrun 
Published: February 2024

PEF (Pulsed Electric Field) adalah sebuah teknologi pengawetan pangan yang menggunakan metode non termal, dimana peningkatan suhu yang dihasilkan selama proses perlakuan sangat rendah Pulsed Electric Field (PEF) merupakan suatu teknologi pengawetan pangan non thermal karena kenaikan suhu yang dihasilkan rendah selama proses perlakuan. Perlakuan PEF berpotensi sebagai metode pemrosesan minimal. Tujuan penelitian ini adalah untuk merancang sebuah alat pulsed electric field yang digunakan untuk reduksi bakteri produk perikanan dengan sampel fillet ikan tongkol, dengan metode research and development yang menghasilkan sebuah alat dengan spesifikasi output luaran 1kV hingga 5kV, square pulse, 2 amphere serta mampu untuk mereduksi bakteri halofilik dengan sampel ikan tongkol. Perlakuan fillet ikan tongkol dengan tegangan 1kV-5kV dengan masing-masing durasi 10,20,30 detik pada setiap perlakuan menghasilkan titik perlakuan optimum 5kV dengan durasi 30 detik mampu mereduksi bakteri halofilik.
Pengaruh Kompetensi SDM, Locus of Control dan Teknologi Informasi Terhadap Kinerja Pegawai (Studi pada Rumah Sakit Islam Fatimah Cilacap)
Authors: Nurahmat Aris , Budianto Apri , Herman Ferey 
Published: February 2024

Tujuan penelitian ini untuk melihat pengaruh kompetensi, Locus Of Control dan teknologi informasi terhadap kinerja pegawai. Rumusan masalah yang diajukan dalam penelitian ini yaitu 1) Pengaruh kompetensi terhadap kinerja pegawai. 2) Pengaruh Locus Of Control terhadap kinerja pegawai. 3) Pengaruh teknologi informasi terhadap kinerja pegawai. 4) Pengaruh kompetensi, Locus Of Control dan teknologi informasi terhadap kinerja pegawai di Rumah Sakit Islam Fatimah Cilacap.
Metode penelitian yang digunakan adalah metode kuantitatif deskriptif. Teknik sampling yang digunakan adalah simple random sampling. Teknik pengumpulan data dalam penelitian ini adalah wawancara, kuesioner, observasi. Sedangkan teknis analisis yang digunakan dilakukan dengan program SPSS (Statistical Product Service Solution) versi 22.0 for windows. Dari hasil penelitian diperoleh bahwa kompetensi, Locus Of Control dan teknologi informasi pada Rumah Sakit Islam Fatimah Cilacap berpengaruh positif terhadap kinerja dan berpengaruh signifikan, artinya apabila kompetensi, Locus Of Control dan teknologi informasi yang sangat tinggi maka akan berpengaruh terhadap kinerja pegawai. Jadi variabel X1, X2 dan X3 adalah faktor utama dalam meningkatkan kinerja pegawai di Rumah Sakit Islam Fatimah Cilacap.
Investigating the Frost Dilatometry Methodology and Critical Degree of Saturation of Brick Slices Versus Half Brick Samples
Authors: Lee Catherine 
Published: February 2024

<p>This study investigates the susceptibility of clay brick masonry to freeze‐thaw deterioration using the frost dilatometry methodology. Trends between the critical degree of saturation (S<sub>crit</sub>) and varying sizes of clay bricks are examined to see if differences in material composition and pore structure impact the durability classification relative to freeze‐thaw damage. Previous research has investigated the S<sub>crit </sub>for different sized clay brick masonry, however a disconnect exists between relating the specimen size to the resulting degree of frost damage. Therefore, a gap is present in the understanding of what size sample is most representative of a bricks durability as a whole and can sufficiently predict the performance of a brick in service. For this study, 2D and 3D frost dilatometry testing was conducted on brick slices and half brick samples from 14 historical bricks. Strain was measured along the x, y and z‐ axes to assess the resulting effect of frost decay. </p>
<p>Results showed that the S<sub>crit </sub>does appear to be impacted based on the size of the specimen being tested. Smaller sized samples (brick slices) typically resulted in a higher S<sub>crit</sub> than larger samples (half bricks). For instance, samples U3, U4 and U5, which all originate from the same building had a projected S<sub>crit </sub>of 88%, 89% and 88% respectively, when tested as brick slices. However, testing from the half bricks resulted in projected S<sub>crits </sub>of 72%, 77% and 76% respectively. This shift in the projected S<sub>crit </sub>was significant enough to alter the durability classification of each brick. Thus, it was found that out of a total 13 brick samples 11 (85%) were considered to be sufficiently durable, 2 (15%) questionably durable and none were deemed not durable, based on the data collected from testing brick slices. In comparison, to testing conducted on half bricks that found only 2 (15%) samples were considered sufficiently durable, 9 (69%) questionably durable and 2 (15%) were deemed not durable. These findings highlight the importance of standardizing a methodology for frost dilatometry testing to help ensure the durability performance of bricks are being assessed in a comparable manner.</p>
PSIKOLOGI BERMAIN ANAK USIA DINI DALAM MENSTIMULASI PERKEMBANGAN OTAK
Authors: Diananda Amita 
Published: February 2024

In a psychological context, playing is an activity involving all psychological functions in a variety of situations. Playing in a child's world is a fun activity. Many things are gained in playing, such as new experiences, new skills, knowing various rules in the game, being able to discern various emotional conditions that may arise (such as pleasure, joy, tension, satisfaction, and maybe disappointment, too). Thus, psychologically, playing can help develop the potential that exists in children and help improve children's abilities in solving various known problems, as well as recognizing and obeying all existing rules. Besides that, it can also teach children to speak honestly, faithfully, and so on. All of these will be able to stimulate cognitive, social, emotional, motoric, and other intelligence development. The playground also plays a major role in increasing children's intelligence and caring. The results showed that children who were rarely stimulated by playing and be conscious of their environmentÂ t play had their brain growth and development about 20 or 30 percent smaller than their normal size. As a result, brain dysfunction occurs which affects the intelligence and reactive ability of children to respond to everything that happens in their environment. The brain also requires adequate nutritional intake. Malnutrition in the brain results in a decrease in the brain's ability to receive, record, store, process, exercise, respond to, produce, and reconstruct information. In the brain, there is a part of brain cells that manage emotions called the amygdala which functions to store old memories related to emotions. This amygdala is related to human emotional behavior that can be changed and/or controlled for the better, such as from fear to being brave, from not caring to being attentive, and so on.
Pola Asuh Orang Tua Tunggal Dalam Membentuk Akhlak Terpuji Anak
Authors: Kaesuroh Dede , Budiana Irma 
Published: February 2024

The purpose of this study was to find out how single parent parenting styles in shaping childrenâ€™s morals and to find out the morals of children raised by single parents. This research is qualitative field research. The research subjects were single parents in the helmet of 06 Kiara Payung Village. Data sources come from primary and secondary data. Data collection techniques are by observation, interview and documentation or archives. The data validity or validity tes technique used in this study is sources. Data analysis techniques used in this study are interactive data analysis techniques including the data collection stage, the data reduction stage, the data presentation stage and the conclusion drawing stage. The results showed the single parents parenting pattern in hamlet 06 of Kiara Payung Village used a democratic parenting pattern where single parents were good enough to take care of their childrenÂ by conducting deliberation when making several choices. Parents also give freedom but not absolute control by parents and establish good communication and provide moral guidance. The character of the child is quite good but there are bad sides such as lying, fighting and others.
Peran Orang Tua Dalam Membentuk Kedisiplinan Anak Usia 5-6 Tahun
Authors: Sari Dewi Sekar , Alawiyah Neneng 
Published: February 2024

Discipline is a character trait that every student requires. Failure to form this trait can result in students having difficulty in self-management. The purpose of this study was to find out the role of parents in shaping the discipline of their 5-6 years old children, both in the school environment and at home. This research used a descriptive approach with qualitative research methods (field research). The data was collected through observation, interviews, and documentation with a research time of one month. The research subjects were students between 5-6 years old in class B of the Cempaka Putri Curug Tangerang Kindergarten. The data acquired from the parents and students in the form of observations, teacher and parents interview, and documentation. Data analysis carried out inductively with data reduction, data presentation, conclusions, and verification. The data validated through triangulation technique. The result of the study indicate that parents have a critical role and tremendous influence in shaping the children's discipline.Â Parents, assisted by teachers in school, has a clear impact in forming the children's discipline from their early age that will turn into a practice they will carry into their future.
Application of 3D printed titanium mesh and digital guide plate in the repair of mandibular defects using double-layer folded fibula combined with simultaneous implantation
Authors: Li Shangbo , Mi Lian , Bai Li , Liu Zijian , Li Li , Wu Yupeng , Chen Liqiang , Bai Na , Sun Jian , Liu Yanshan 
Published: February 2024

Fibula transplantation plays an irreplaceable role in restoring the function and morphology of the defected mandible. However, the complex load-bearing environment of the mandible makes it urgent to accurately reconstruct the mandible, ensure the position of the condyle after surgery, and restore the patient’s occlusal function and contour. The intervention of digital design and three-dimensional (3D) printed titanium mesh provides a more efficient method and idea to solve this problem. Digital design guides the accurate positioning, osteotomy, and simultaneous implant placement during surgery, and 3D printed titanium mesh ensures stable condyle position after surgery, restoring good mandibular function. The double-layer folded fibula maintains the vertical height of the mandible and a good facial contour, and simultaneous implant placement can establish a good occlusal relationship. This study conducted a retrospective analysis of five patients with jaw defects who underwent digital fibula reconstruction over the past 3 years. It was found that the surgical protocol combining digital design, 3D printed intraoperative guides, 3D printed titanium mesh, free fibula flap, immediate implant, and occlusal reconstruction to repair jaw defects had more ideal facial appearance and biological function. It will provide a more reliable surgical protocol for clinical management of large mandibular defects.
Stemness properties of SSEA-4+ subpopulation isolated from heterogenous Wharton’s jelly mesenchymal stem/stromal cells
Authors: Smolinska Agnieszka , Chodkowska Magdalena , Kominek Agata , Janiec Jakub , Piwocka Katarzyna , Sulejczak Dorota , Sarnowska Anna 
Published: February 2024

Background: High heterogeneity of mesenchymal stem/stromal cells (MSCs) due to different degrees of differentiation of cell subpopulations poses a considerable challenge in preclinical studies. The cells at a pluripotent-like stage represent a stem cell population of interest for many researchers worldwide, which is worthy of identification, isolation, and functional characterization. In the current study, we asked whether Wharton’s jelly-derived MSCs (WJ-MSCs) which express stage-specific embryonic antigen-4 (SSEA-4) can be considered as a pluripotent-like stem cell population.Methods: SSEA-4 expression in different culture conditions was compared and the efficiency of two cell separation methods were assessed: Magnetic Activated Cell Sorting (MACS) and Fluorescence Activated Cell Sorting (FACS). After isolation, SSEA-4+ cells were analyzed for the following parameters: the maintenance of the SSEA-4 antigen expression after cell sorting, stem cell-related gene expression, proliferation potential, clonogenicity, secretome profiling, and the ability to form spheres under 3D culture conditions.Results: FACS allowed for the enrichment of SSEA-4+ cell content in the population that lasted for six passages after sorting. Despite the elevated expression of stemness-related genes, SSEA-4+ cells neither differed in their proliferation and clonogenicity potential from initial and negative populations nor exhibited pluripotent differentiation repertoire. SSEA-4+ cells were observed to form smaller spheroids and exhibited increased survival under 3D conditions.Conclusion: Despite the transient expression of stemness-related genes, our findings could not fully confirm the undifferentiated pluripotent-like nature of the SSEA-4+ WJ-MSC population cultured in vitro.
Virtual calcium removal in calcified coronary arteries with photon-counting detector CT—first in-vivo experience
Authors: Mergen Victor , Rusek Stéphane , Civaia Filippo , Rossi Philippe , Rajagopal Rengarajan , Bättig Eduardo , Manka Robert , Candreva Alessandro , Eberhard Matthias , Alkadhi Hatem 
Published: February 2024

PurposeTo evaluate the feasibility and accuracy of quantification of calcified coronary stenoses using virtual non-calcium (VNCa) images in coronary CT angiography (CCTA) with photon-counting detector (PCD) CT compared with quantitative coronary angiography (QCA).Materials and methodsThis retrospective, institutional-review board approved study included consecutive patients with calcified coronary artery plaques undergoing CCTA with PCD-CT and invasive coronary angiography between July and December 2022. Virtual monoenergetic images (VMI) and VNCa images were reconstructed. Diameter stenoses were quantified on VMI and VNCa images by two readers. 3D-QCA served as the standard of reference. Measurements were compared using Bland-Altman analyses, Wilcoxon tests, and intraclass correlation coefficients (ICC).ResultsThirty patients [mean age, 64 years ± 8 (standard deviation); 26 men] with 81 coronary stenoses from calcified plaques were included. Ten of the 81 stenoses (12%) had to be excluded because of erroneous plaque subtraction on VNCa images. Median diameter stenosis determined on 3D-QCA was 22% (interquartile range, 11%–35%; total range, 4%–88%). As compared with 3D-QCA, VMI overestimated diameter stenoses (mean differences −10%, p &lt; .001, ICC: .87 and −7%, p &lt; .001, ICC: .84 for reader 1 and 2, respectively), whereas VNCa images showed similar diameter stenoses (mean differences 0%, p = .68, ICC: .94 and 1%, p = .07, ICC: .93 for reader 1 and 2, respectively).ConclusionFirst experience in mainly minimal to moderate stenoses suggests that virtual calcium removal in CCTA with PCD-CT, when feasible, has the potential to improve the quantification of calcified stenoses.
Divergent electrophysiologic action of dapagliflozin and empagliflozin on ventricular and atrial tachyarrhythmias in isolated rabbit hearts
Authors: Wolfes Julian , Uphoff Jan , Kemena Sven , Wegner Felix , Rath Benjamin , Eckardt Lars , Frommeyer Gerrit , Ellermann Christian 
Published: February 2024

BackgroundThe use of SGLT-2 inhibitors has revolutionized heart failure therapy. Evidence suggests a reduced incidence of ventricular and atrial arrhythmias in patients with dapagliflozin or empagliflozin treatment. It is unclear to what extent the reduced arrhythmia burden is due to direct effects of the SGLT2 inhibitors or is solely a marker of improved cardiac function.MethodsOne hundred five rabbit hearts were allocated to eight groups and retrogradely perfused, employing a Langendorff setup. Action potential duration at 90% of repolarization (APD90), QT intervals, effective refractory periods, conduction velocity, and dispersion of repolarization were obtained with monophasic action potential catheters. A model for tachyarrhythmias was established with the IKr blocker erythromycin for QT prolongation associated proarrhythmia as well as the potassium channel opener pinacidil for a short-QT model. An atrial fibrillation (AF) model was created with isoproterenol and acetylcholine. With increasing concentrations of both SGLT2 inhibitors, reductions in QT intervals and APD90 were observed, accompanied by a slight increase in ventricular arrhythmia episodes. During drug-induced proarrhythmia, empagliflozin succeeded in decreasing QT intervals, APD90, and VT burden whereas dapagliflozin demonstrated no significant effects. In the presence of pinacidil induced arrhythmogenicity, neither SGLT2 inhibitor had a significant impact on cardiac electrophysiology. In the AF setting, perfusion with dapagliflozin showed significant suppression of AF in the course of restitution of electrophysiological parameters whereas empagliflozin showed no significant effect on atrial fibrillation incidence.ConclusionIn this model, empagliflozin and dapagliflozin demonstrated opposite antiarrhythmic properties. Empagliflozin reduced ventricular tachyarrhythmias whereas dapagliflozin showed effective suppression of atrial arrhythmias.
The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants
Authors: He Lingjie , Xuan Wenting , Liu Dixing , Zhong Jiana , Luo Huijin , Cui Han , Zhang Xiuwei , Chen Weikun 
Published: February 2024

BackgroundAdiposity and adipokines are closely associated with obesity-related metabolic abnormalities, but little is known regarding whether abdominal obesity is linked to type 2 diabetes mellitus (T2DM) through circulating adiponectin levels. Thus, this large-population–based study was designed to investigate the mediating effect of adiponectin in the relationship between abdominal obesity and T2DM.MethodsA total of 232,438 adults who lived in Dongguan, Guangdong Province, China, were enrolled in the present study. The circulating adiponectin concentrations were measured using latex-enhanced immunoturbidimetric assay. The association between circulating adiponectin and other clinical parameters was detected by Spearman’s correlation analysis. Restricted cubic spline (RCS) regression was also used to address the non-linearity of the relationship between waist circumference and diabetes. Mediation analyses of circulating adiponectin were conducted using linear and logistic regression.ResultsSubjects with abdominal obesity had lower levels of circulating adiponectin (P &lt; 0.001). The circulating adiponectin value was inversely related to BMI (r = −0.370, P &lt; 0.001), waist circumference (r = −0.361, P &lt; 0.001), and fasting plasma glucose (r = −0.221, P &lt; 0.001). The RCS plot showed a non-linear relation linking waist circumference with T2DM (P for non-linearity &lt; 0.001). Patients with abdominal obesity presented 2.062 times higher odds of T2DM in comparison with those with non-abdominal obesity (odds ratio, 2.062; 95% confidence interval, 1.969–2.161) after adjusting for confounders. In the mediation analyses, the circulating adiponectin mediated the association between abdominal obesity and T2DM, with a mediation effect of 41.02% after adjustments. The above results were consistent in both men and women.ConclusionThe relationship between abdominal obesity and T2DM is mediated through circulating adiponectin level in adults, suggesting that circulating adiponectin might be a potential predictor for controlling the adverse progression from adiposity to T2DM.
Effect of environmental factors on seminal microbiome and impact on sperm quality
Authors: Neto Filipe T. Lira , Viana Marina C. , Cariati Federica , Conforti Alessandro , Alviggi Carlo , Esteves Sandro C. 
Published: February 2024

ObjectiveThis review provides a comprehensive overview of the existing research on the seminal microbiome and its association with male infertility, while also highlighting areas that warrant further investigation.MethodsA narrative review was conducted, encompassing all relevant studies published between 1980-2023 on the male reproductive tract microbiome in humans. This review considered studies utilizing culture-based, polymerase chain reaction (PCR)-based, and next-generation sequencing (NGS)-based methodologies to analyze the microbiome. Data extraction encompassed sample types (semen or testicular tissue), study designs, participant characteristics, employed techniques, and critical findings.ResultsWe included 37 studies comprising 9,310 participants. Among these, 16 studies used culture-based methods, 16 utilized NGS, and five employed a combination of methods for microorganism identification. Notably, none of the studies assessed fungi or viruses. All NGS-based studies identified the presence of bacteria in all semen samples. Two notable characteristics of the seminal microbiome were observed: substantial variability in species composition among individuals and the formation of microbial communities with a dominant species. Studies examining the testicular microbiome revealed that the testicular compartment is not sterile. Interestingly, sexually active couples shared 56% of predominant genera, and among couples with positive cultures in both partners, 61% of them shared at least one genital pathogen. In couples with infertility of known causes, there was an overlap in bacterial composition between the seminal and vaginal microbiomes, featuring an increased prevalence of Staphylococcus and Streptococcus genera. Furthermore, the seminal microbiome had discernible effects on reproductive outcomes. However, bacteria in IVF culture media did not seem to impact pregnancy rates.ConclusionExisting literature underscores that various genera of bacteria colonize the male reproductive tract. These organisms do not exist independently; instead, they play a pivotal role in regulating functions and maintaining hemostasis. Future research should prioritize longitudinal and prospective studies and investigations into the influence of infertility causes and commonly prescribed medication to enhance our understanding of the seminal microbiota’s role in reproductive health.