bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of immune-related signatures and pathogenesis differences between thoracic aortic aneurysm patients with bicuspid versus tricuspid valves via weighted gene co-expression network analysis
Authors: Huang Min , Guan Rong , Qiu Jiawei , Gnamey Abla Judith Estelle , Wang Yusi , Tian Hai , Sun Haoran , Shi Hongbo , Sun Wenjing , Jia Xueyuan , Wu Jie 
Published: October 2023

Background
Thoracic aortic aneurysm (TAA) occurs due to pathological aortal dilation, and both individuals with normal tricuspid aortic valves (TAV) or abnormal bicuspid aortic valves (BAV), the latter being a congenital condition, are at risk. However, some differences are present between TAA/BAV and TAA/TAV with respect to their pathophysiological processes and molecular mechanisms, but their exact nature is still mostly unknown. Therefore, it is necessary to elucidate TAA developmental differences among BAV vs. TAV patients.

Methods
Publically-available gene expression datasets, aortic tissue derived from TAA/BAV and TAA/TAV individuals, were analyzed by weighted gene co-expression network analysis (WGCNA) to identify gene modules associated with those conditions. Gene Ontology (GO) enrichment analysis was performed on those modules to identify the enriched genes within those modules, which were verified by Gene Set Variation Analysis (GSVA) on a dataset derived from aortic smooth muscle cell gene expression between TAA/TAV and TAV/BAV patients. Immune cell infiltration patterns were then analyzed by CIBERSORT, and a protein-protein interaction (PPI) network was constructed based on WGCNA and enrichment analysis results to identify hub genes, followed by validation via stepwise regression analysis. Three signatures most strongly associated with TAA/TAV were confirmed by receiver operating characteristic (ROC) and decision curve analyses (DCA) between prior-established training and testing gene sets.

Results
WGCNA delineated 2 gene modules being associated with TAA/TAV vs. TAA/BAV; both were enriched for immune-associated genes, such as those relating to immune responses, etc., under enrichment analysis. TAA/TAV and TAA/BAV tissues also had differing infiltrating immune cell proportions, particularly with respect to dendritic, mast and CD4 memory T cells. Identified three signatures, CD86, integrin beta 2 (ITGB2) and alpha M (ITGAM), as yielding the strongest associations with TAA/TAV onset, which was verified by areas under the curve (AUC) at levels approximating 0.8 or above under ROC analysis, indicating their predictive value for TAA/TAV onset. However, we did not examine possible confounding variables, so there are many alternative explanations for this association.

Conclusions
TAA/TAV pathogenesis was found to be more associated with immune-related gene expression compared to TAA/BAV, and the identification of three strongly-associated genes could facilitate their usage as future biomarkers for diagnosing the likelihood of TAA/TAV onset vs. TAA/BAV, as well as for developing future treatments.
Exploring reasons why South African dental therapists are leaving their profession: A theory-informed qualitative study
Authors: Sodo Pumla Pamella , Malele-Kolisa Yolanda , Moola Aneesa , Yengopal Veerasamy , Nemutandani Simon , Jewett Sara 
Published: October 2023

Background
Dental therapy is a category of mid-level oral health professional that was introduced to address inequities in oral health service provision in South Africa within a constrained human resource for health context. However, low numbers of registered dental therapists and attrition threaten this strategy.

Aim
This study explored reasons for this attrition, building on the Hertzberg Two-Factor Theory.

Methods
Through a qualitative exploratory study design, in-depth interviews were conducted with former dental therapists to explore their reasons for leaving the profession. They were recruited using snowball sampling. All interviews were audio recorded, transcribed verbatim, and coded in NVIVO12. A team of researchers applied thematic analysis to agree on themes and sub-themes, guided by Hertzberg’s ideas of intrinsic and extrinsic factors.

Findings
All 14 former dental therapists interviewed expressed their passion for the profession, even though their motivations to join the profession varied. Many of their reasons for leaving aligned with extrinsic and intrinsic factors defined in Hertzberg’s Two-Factor Theory. However, they also spoke about a desire for a professional identity that was recognized and respected within the oral health profession, health system, and communities. This is a novel study contribution.

Conclusion
Dental therapist attrition in South Africa is mainly caused by job dissatisfaction and motivation issues resulting from health system level factors. While the Hertzberg Two-Factor Theory helped identify extrinsic and intrinsic factors at an individual level, we used the Human Resources for Health System Development Analytical Framework to identify solutions for dental therapist production, deployment, and retention. Addressing these issues will enhance retention and accessibility to oral health services in the country.
Quantitative radiomics approach to assess acute radiation dermatitis in breast cancer patients
Authors: Park So-Yeon , Park Jong Min , Kim Jung-in , Choi Chang Heon , Chun Minsoo , Chang Ji Hyun , Kim Jin Ho 
Published: October 2023

Purpose
We applied a radiomics approach to skin surface images to objectively assess acute radiation dermatitis in patients undergoing radiotherapy for breast cancer.

Methods
A prospective cohort study of 20 patients was conducted. Skin surface images in normal, polarized, and ultraviolet (UV) modes were acquired using a skin analysis device before starting radiotherapy (‘Before RT’), approximately 7 days after the first treatment (’RT D7’), on ‘RT D14’, and approximately 10 days after the radiotherapy ended (‘After RT D10’). Eighteen types of radiomic feature ratios were calculated based on the values acquired ‘Before RT’. We measured skin doses in ipsilateral breasts using optically stimulated luminescent dosimeters on the first day of radiotherapy. Clinical evaluation of acute radiation dermatitis was performed using the Radiation Therapy Oncology Group scoring criteria on ‘RT D14’ and ‘After RT D10’. Several statistical analysis methods were used in this study to test the performance of radiomic features as indicators of radiodermatitis evaluation.

Results
As the skin was damaged by radiation, the energy for normal mode and sum variance for polarized and UV modes decreased significantly for ipsilateral breasts, whereas contralateral breasts exhibited a smaller decrease with statistical significance. The radiomic feature ratios at ‘RT D7’ had strong correlations to skin doses and those at ‘RT D14’ and ‘after RT D10’ with statistical significance.

Conclusions
The energy for normal mode and sum variance for polarized and UV modes demonstrated the potential to evaluate and predict acute radiation, which assists in its appropriate management.
A systematic review of passing fit testing of the masks and respirators used during the COVID-19 pandemic: Part 1-quantitative fit test procedures
Authors: Fakherpour Anahita , Jahangiri Mehdi , Jansz Janis 
Published: October 2023

BackgroundDuring respiratory infection pandemics, masks and respirators are highly sought after, especially for frontline healthcare workers and patients carrying respiratory viruses. The objective of this study was to systematically review fit test pass rates and identify factors influencing the fitting characteristics.MethodsPotentially relevant studies were identified using PubMed, Scopus, Web of Science, and Science Direct during the COVID-19 pandemic from February 5, 2020, to March 21, 2023. The search strategy using the following keywords was conducted: Quantitative Fit Test, Condensation Nuclei Counter, Controlled Negative Pressure, PortaCount, Sibata, Accufit, Fit, Seal, Mask, Respirator, Respiratory Protective Device, Respiratory Protective Equipment, Protective Device, Personal Protective Equipment, COVID-19, Coronavirus, and SARS-CoV-2. The quality of the included studies was also assessed using the Newcastle-Ottawa scale.ResultsA total of 137 articles met the eligibility criteria. Fifty articles had a quality score of less than 7 (good quality). A total of 21 studies had a fit test pass rate of less than 50%. 26 studies on disposable respirators and 11 studies on reusable respirators had an FF of less than 50 and less than 200, respectively. The most influential factors include respirator brand/model, style, gender, ethnicity, facial dimensions, facial hair, age, reuse, extensive movement, seal check, comfort and usability assessment, and training.Conclusion37.36% of the disposable respirator studies and 43% of the reusable respirator studies did not report fit test results. 67.86% of the disposable respirator studies had a fit test pass rate greater than 50%, and 35.84% of these studies had an FF greater than 100. Also, 85.71% of the reusable respirator studies had a fit test pass rate greater than 50%, and 52.77% of these studies had an FF greater than 1000. Overall, the fit test pass rate was relatively acceptable. Newly developed or modified respirators must undergo reliable testing to ensure the protection of HCWs. Subject and respirator characteristics should be considered when implementing fit testing protocols. An optimal fit test panel should be developed prior to respirator design, certification, procurement decisions, and selection procedures.
Prediction model for in-hospital mortality in patients at high altitudes with ARDS due to COVID-19
Authors: Rodriguez Lima David Rene , Rubio Ramos Cristhian , Yepes Velasco Andrés Felipe , Gómez Cortes Leonardo Andrés , Pinilla Rojas Darío Isaías , Pinzón Rondón Ángela María , Ruíz Sternberg Ángela María 
Published: October 2023

Introduction
The diagnosis of acute respiratory distress syndrome (ARDS) includes the ratio of pressure arterial oxygen and inspired oxygen fraction (P/F) ≤ 300, which is often adjusted in locations more than 1,000 meters above sea level (masl) due to hypobaric hypoxemia. The main objective of this study was to develop a prediction model for in-hospital mortality among patients with ARDS due to coronavirus disease 2019 (COVID-19) (C-ARDS) at 2,600 masl with easily available variables at patient admission and to compare its discrimination capacity with a second model using the P/F adjusted for this high altitude.

Methods
This study was an analysis of data from patients with C-ARDS treated between March 2020 and July 2021 in a university hospital located in the city of Bogotá, Colombia, at 2,600 masl. Demographic and laboratory data were extracted from electronic records. For the prediction model, univariate analyses were performed to screen variables with p <0.25. Then, these variables were automatically selected with a backward stepwise approach with a significance level of 0.1. The interaction terms and fractional polynomials were also examined in the final model. Multiple imputation procedures and bootstraps were used to obtain the coefficients with the best external validation. In addition, total adjustment of the model and logistic regression diagnostics were performed. The same methodology was used to develop a second model with the P/F adjusted for altitude. Finally, the areas under the curve (AUCs) of the receiver operating characteristic (ROC) curves of the two models were compared.

Results
A total of 2,210 subjects were included in the final analysis. The final model included 11 variables without interaction terms or nonlinear functions. The coefficients are presented excluding influential observations. The final equation for the model fit was g(x) = age(0.04819)+weight(0.00653)+height(-0.01856)+haemoglobin(-0.0916)+platelet count(-0.003614)+ creatinine(0.0958)+lactate dehydrogenase(0.001589)+sodium(-0.02298)+potassium(0.1574)+systolic pressure(-0.00308)+if moderate ARDS(0.628)+if severe ARDS(1.379), and the probability of in-hospital death was p (x) = e g (x)/(1+ e g (x)). The AUC of the ROC curve was 0.7601 (95% confidence interval (CI) 0.74–0, 78). The second model with the adjusted P/F presented an AUC of 0.754 (95% CI 0.73–0.77). No statistically significant difference was found between the AUC curves (p value = 0.6795).

Conclusion
This study presents a prediction model for patients with C-ARDS at 2,600 masl with easily available admission variables for early stratification of in-hospital mortality risk. Adjusting the P/F for 2,600 masl did not improve the predictive capacity of the model. We do not recommend adjusting the P/F for altitude.
Flanders Nursing Home (FLANH) project: Protocol of a multicenter longitudinal observational study on staffing, work environment, rationing of care, and resident and care worker outcomes
Authors: Geyskens Lisa , Declercq Anja , Milisen Koen , Flamaing Johan , Deschodt Mieke ,   the FLANH research consortium
Published: October 2023

Background
While the demand for high quality of care in nursing homes is rising, it is becoming increasingly difficult to recruit and retain qualified care workers. To date, evidence regarding key organizational factors such as staffing, work environment, and rationing of care, and their relationship with resident and care worker outcomes in nursing homes is still scarce. Therefore, the Flanders Nursing Home (FLANH) project aims to comprehensively examine these relationships in order to contribute to the scientific knowledge base needed for optimal quality of care and workforce planning in nursing homes.

Methods
FLANH is a multicenter longitudinal observational study in Flemish nursing homes based on survey and registry data that will be collected in 2023 and 2025. Nursing home characteristics and staffing variables will be collected through a management survey, while work environment variables, rationing of care, and care worker characteristics and outcomes will be collected through a care worker survey. Resident characteristics and outcomes will be retrieved from the Belgian Resident Assessment Instrument for long-Term Care Facilities (BelRAI LTCF) database. Multilevel regression analyses will be applied to examine the relationships between staffing variables, work environment variables, and rationing of care and resident and care worker outcomes.

Conclusion
This study will contribute to a comprehensive understanding of the nursing home context and the interrelated factors influencing residents and care workers. The findings will inform the decision-making of nursing home managers and policymakers, and evidence-based strategies to optimize quality of care and workforce planning in nursing homes.
Projecting Nation: South African Cinemas after 1994, Cara Moyer-Duncan (2020)
Authors: Mututa Addamms 
Published: October 2023

Review of: Projecting Nation: South African Cinemas after 1994, Cara Moyer-Duncan (2020)
East Lansing, MI: Michigan State University Press, 298 pp.,
ISBN 978-1-60917-638-9, e-book, $54.95
“aMorales” en dictadura. Vertiente material de las violencias hacia las disidencias sexo-genéricas a través del estudio de caso de la Policía de la provincia de Buenos Aires (1976-1983) (Segunda Parte)
Authors: Solari Paz Ana Cecilia 
Published: October 2023

Esta investigación es un aporte a la construcción de conocimiento que pretende profundizar la pregunta sobre el objetivo de “exterminio” del terrorismo de Estado implementado por la última dictadura argentina (1976-1983), aportando una serie de elementos para pensar qué quedó fuera de la mira de este gran proceso represivo que produjo muertes, desapariciones, que destruyó toda una serie de sujetxs, para poder pensar en otros temas que fueron reprimidos mucho menos visiblemente.
Este proyecto se inserta en el campo de los estudios de Historia Reciente Argentina y estudios de Terrorismo de Estado, enfocados desde una perspectiva sexo genero disidente, mirando desde el presente cosas que no se han visto desde ese lugar, que no aparecen en las historias dominantes.
Mi propósito consiste en reconstruir la estructura y el funcionamiento de la Policía de la provincia de Buenos Aires durante el periodo, para poder identificar, a posteriori, las áreas encargadas de la represión hacia las disidencias sexo genéricas y sus múltiples y diversas prácticas desplegadas en el territorio, enmarcadas en un momento particular de la historia argentina, en el que el Proceso de Reorganización Nacional puso en funcionamiento una maquinaria del terror, un accionar represivo inédito en sus características, dispositivos y escalas, con el objetivo de “realizar un escarmiento histórico a quien subvierta la norma”, se propuso “exterminar al enemigo”, al “terrorista”, que “es cualquiera que difunde ideas que son contrarias a la civilización occidental y cristiana”, que es quien produce un “trastocamiento de los valores tradicionales; es decir, subversión. Porque subversión no es ni más ni menos que eso: subversión de los valores esenciales del ser nacional”, “subversivos” que “apuntan a destruir la familia, la sociedad y los pilares fundamentales de la República”.
Recorrido sensible en las calles de chimalhuacán: cuerpo y emociones en una marcha feminista*
Authors: Carpio Pacheco Carla V. 
Published: October 2023

Las marchas son un recurso ampliamente utilizado por la protesta social sobre todo en ámbitos urbanos. Su presencia en las calles hace visibles y tangibles los cuerpos indignados, incluso de quienes ya no están pero que alzan la voz a través de quienes salen a las calles. El objetivo de este artículo es mostrar la relevancia de las marchas feministas como dispositivo de la protesta social y su interacción con el espacio urbano a partir de la noción de corpografías urbanas, lo que permite analizar el vínculo de las emociones y el cuerpo en el activismo político. De modo particular me refiero al caso de la Marcha contra las violencias machistas en el municipio de Chimalhuacán, Estado de México en 2017 que describo a partir de mi trabajo de investigación participante. Este artículo pretende contribuir en la investigación interdisciplinar de las protestas sociales, en particular las marchas feministas de la cuarta ola que han puesto en práctica formas novedosas de ocupación del espacio público. Asimismo, se pretende mostrar el desarrollo de dichas manifestaciones que movilizan una serie de redes de apoyo y creación colectiva de las que la marcha es sólo el resultado más visible.
Analisis Sistem Keselamatan dan Kesehatan Kerja pada Lingkungan Area Berbahaya
Authors: Setiawan Enggal , Nugroho Agung , Zaman Badrus 
Published: October 2023

Analisis sistem keselamatan kerja khususnya dalam tata aturan penggunaan peralatan listrik yang digunakan di lingkungan area berbahaya merupakan bagian yang sangat penting dalam suatu proses industri,terutama dengan keberadaan bahan kimia berupa gas yang mudah terbakar yang menjadi alasan bahwa area tersebut termasuk dalam kategori area berbahaya. Standar sistem keamanan peralatan listrik berdasarkan ketentuan ATEX dan lembaga sertifikasi peralatan teknis pada area berbahaya sebagai hal mutlak yang harus diperhatikan. Berdasarkan analisis yang dilakukan, menunjukkan peralatan listrik yang digunakan pada area berbahaya sudah sesuai dengan standar keselamatan dan sudah tersertifikasi untuk penggunaan di area berbahaya dengan disertai kajian terhadap faktor resiko dan cara penanggulangan bahaya. Sebagai data referensi, dilakukan perbandingan dengan acuan dari jurnal Keselamatan dan Kesehatan Kerja, Keberlanjutan melalui perusahaan yang kompetitif dan bertanggung jawab (SCORE) yang dipublikasi oleh ILO (International Labour Organization). Kata kunci: Keselamatan dan kesehatan kerja; Area berbahaya; Peralatan listrik; KlasifikasiAbstract [Analysis of occupational safety and health systems in hazardous area environments] Analysis of work safety systems, especially in the regulation of the use of electrical equipment used in the environment of hazardous areas is a very important part in an industrial process, especially with the presence of chemicals in the form of flammable gases which is the reason that the area is included in the hazardous area category. Electrical equipment safety system standards based on ATEX regulations and technical equipment certification bodies in hazardous areas are absolutely essential. Based on the analysis carried out, it shows that electrical equipment used in hazardous areas is in accordance with safety standards and has been certified for use in hazardous areas accompanied by a study of risk factors and how to deal with hazards. As reference data, a comparison is made with references from the journal Occupational Safety and Health, Sustainability through competitive and responsible companies (SCORE) published by the ILO (International Labor Organization). Keywords: Occupational safety and health; Hazardous areas; Electrical equipment in hazardous areas; Classification of hazardous areas; K3 in hazardous areas.
PEMASANGAN PIPA HDPE PADA PENYAMBUNGAN PIPA IRIGASI DENGAN METODE BUTT FUSION
Authors: Syafrizal Dery , Widayat W , Darsono Suseno 
Published: October 2023

This paper was made based on the experience of implementing a network development project of the raw Spam Regional transmission pipeline BANJARBAKULA from IPA II Pinus (Kab. Banjar) to IPA Pramuka (Banjarmasin city). The path to be traversed installation of pipes not all can be accessed properly to mobilize pipes to the location, until another alternative is found SO that HDPE pipe OD 710 mm to the location of the Pipeline installation plan, by the WAY of unwrapped HDPE pipe OD 710 mm in the irrigation channel primary Riam Kanan. Connection of HDPE pipe divided by two namely short circuit and long circuit with connection method using butt Fusion tool, until the pipe is connected to a single unit and hydrotest test results meet the required specifications. Keywords : HDPE pipe OD 710 mm, butt fusion, curtain pipe, hydrotest