bluuebunny/crossref_metadata_2025_split huggingface dataset:
Culture for Sale: Unpacking Consumer Perceptions of Cultural Appropriation
Authors: Lin Jason D , Kim Nicole You Jeung , Uduehi Esther , Keinan Anat 
Published: November 2023

Abstract
High-profile instances of brands accused of cultural appropriation suggest that even the most prominent brands fail to fully understand the complexities of this phenomenon. This work experimentally unpacks consumer perceptions of cultural appropriation and its impact on brand attitudes and purchase interest. The authors begin by developing and validating a scale for measuring perceptions of cultural appropriation. Next, a series of studies demonstrates that viewing this phenomenon through a historical lens can help determine when and why the use of cultural elements is viewed as appropriative. Specifically, an emphasis on historical power imbalance explains why liberal consumers are more likely to recognize cultural appropriation and why commercializing disadvantaged cultures is considered appropriation, whereas using elements from advantaged cultures may be more acceptable. The conceptualization further identifies brand actions and interventions that influence perceptions of cultural appropriation, including externally emphasizing historical power imbalance, how brands obtain cultural elements, and how brands represent the culture in their product offerings and marketing. These findings help marketers (1) avoid launching products that can be damaging to the brand and offensive to consumers and (2) understand how to better promote products in a way that prevents rather than amplifies these negative perceptions.
Seeds for New Beginnings? Ecological Uncertainty, Blurry Ideology, and Speculative Design at the Universitas Symposium, 1972
Authors: Halland Ingrid 
Published: November 2023

Abstract
In 1972, designer Emilio Ambasz (b. 1943) organized the symposium “The Universitas Project” at MoMA in New York City. The issue at stake was how the field of design should tackle the possibly irresolvable societal, political, and ecological problems of post-industrial society. Ambasz proposed a new design approach, which he named design as a mode of thought, with the aim of building a new research-education institution for design that could tackle the wicked problems ahead. In order to articulate his proposal, Ambasz turned to the speculative realm: discursive design critique, metaphysical cybernetics, design fiction, and storytelling. By critically engaging with some of the participants’ conference presentations, the article first discusses how the concept of the environment was reconfigured by the emerging ecological catastrophe. Then the article discusses ideological responses to the Universitas Project to show how the seemingly different ideological positions between French so-called “radical left” and American “right-wing technocrats” were grounded in the same; all-encompassing uncertainty and a strive for open-endedness. Finally, the article analyses Ambasz’s design fiction writing and the speculative nature of the Universitas and thereby identifies the Universitas as a rare moment in the history of design in which design stopped engaging in the status quo and turned towards a speculative future for finding seeds for new beginnings. The article re-visits the Universitas in order to support a presentist argument: that speculation, discursive design critique, and storytelling might not be sufficient methods on their own to tackle the forthcoming accelerating wicked uncertainties that lie ahead.
Isolation and characterization of intestinal bacteria associated with cellulose degradation in grasshoppers (Orthoptera)
Authors: Li Wen-Jing , Li Fei-Fei , Bai Jing , Liang Ke , Li Kai , Qin Guo-Qing , Zhang Yu-Long , Li Xin-Jiang 
Published: November 2023

Abstract
Insect gut bacteria play an essential role in the nutritional metabolism, growth, and development of insects. Grasshoppers (Orthoptera) are cellulose-rich plant-feeding pests. Although the biological potential of grasshopper gut microorganisms to assist cellulose decomposition is well established, microbial resources for efficient degradation of cellulose biomass are still scarce and need to be developed. In this study, we used selective media to isolate cellulose-degrading bacteria from the intestines of Atractomorpha sinensis, Trilophidia annulata, Sphingonotus mongolicus, and Calliptamus abbreviatus. Phylogenetic analysis based on the maximum likelihood method using 16S rDNA sequencing sequences to identify bacteria revealed the isolation of 11 strains belonging to 3 genera, including Klebsiella, Aeromonas, and Bacillus. The degradability of the isolates to cellulose was then determined by the DNS colorimetric method, and the results showed that Bacillus had the highest degradation rate. The elucidation of microbial cellulose degradation capacity in grasshoppers not only contributes to the understanding of multiple plant–insect–microbe interactions, but also provides a valuable microbial resource for solving the biomass conversion of cellulose species problem.
Seasonal habitat-use patterns of large mammals in a human-dominated landscape
Authors: Dagtekin Dilsad , Ertürk Alper , Sommer Stefan , Ozgul Arpat , Soyumert Anil 
Published: November 2023

Abstract
Large mammals in temperate climates typically display seasonal patterns of habitat use. However, these patterns are often overlooked because large mammals are usually surveyed at annual intervals. In addition, most studies focus on a single species and ignore other species with which the focal species could interact. Knowing seasonal patterns of habitat use in multiple species and understanding factors that cause these patterns can provide further detail on population dynamics and guide effective conservation planning. Here, using dynamic occupancy modeling, we analyze 11 years of camera-trap data collected in northwestern Anatolia, Turkey, to investigate seasonal habitat use of 8 large-mammal species: Brown Bear (Ursus arctos), Eurasian Lynx (Lynx lynx), Gray Wolf (Canis lupus), Red Fox (Vulpes vulpes), Wild Boar (Sus scrofa), Roe Deer (Capreolus capreolus), European Hare (Lepus europaeus), and Red Deer (Cervus elaphus). For each species, we study the strength of seasonality in habitat use and its dependence on human population density and elevation, which have been shown to affect distributions of species in the region. Although all species exhibited seasonality in habitat use, the strength of this seasonality varied among species; it was strongest in Wild Boar, Roe Deer, and Brown Bear. Moreover, except for Brown Bear, all species tended to avoid sites close to humans. The species responded differently to changing elevation; increasing elevation had both positive and negative effects on species-specific colonization and desertion probabilities, and these effects were likely related to either feeding habits or tendency to avoid humans. These results indicate that seasonality should be taken into consideration in population studies. However, because species differ, seasonality patterns should be identified separately for each species of interest, as differences in these patterns can explain the underlying dynamics of habitat-use patterns more accurately.
Perspective and prospects of in situ transmission/scanning transmission electron microscopy
Authors: Sharma Renu , Yang Wei-Chang David 
Published: November 2023

Abstract
In situ transmission/scanning transmission electron microscopy (TEM/STEM) measurements have taken a central stage for establishing structure–chemistry–property relationship over the past couple of decades. The challenges for realizing ‘a lab-in-gap’, i.e. gap between the objective lens pole pieces, or ‘a lab-on-chip’, to be used to carry out experiments are being met through continuous instrumental developments. Commercially available TEM columns and sample holder, that have been modified for in situ experimentation, have contributed to uncover structural and chemical changes occurring in the sample when subjected to external stimulus such as temperature, pressure, radiation (photon, ions and electrons), environment (gas, liquid and magnetic or electrical field) or a combination thereof. Whereas atomic resolution images and spectroscopy data are being collected routinely using TEM/STEM, temporal resolution is limited to millisecond. On the other hand, better than femtosecond temporal resolution can be achieved using an ultrafast electron microscopy or dynamic TEM, but the spatial resolution is limited to sub-nanometers. In either case, in situ experiments generate large datasets that need to be transferred, stored and analyzed. The advent of artificial intelligence, especially machine learning platforms, is proving crucial to deal with this big data problem. Further developments are still needed in order to fully exploit our capability to understand, measure and control chemical and/or physical processes. We present the current state of instrumental and computational capabilities and discuss future possibilities.
Characteristics of post hoc subgroup analyses of oncology clinical trials: a systematic review
Authors: Alrawabdeh Jawad , Alzu'bi Marah , Alzyoud Muntaser , Odeh Nada , Hamadneh Yazan , Mian Hira , Mohyuddin Ghulam Rehman , Kelkar Amar H , Goodman Aaron M , Chakraborty Rajshekhar , Russler-Germain David A , Mehra Nikita , Baggio Diva , Cliff Edward R Scheffer , Al Hadidi Samer 
Published: November 2023

Abstract

Background
Subgroup analyses in clinical trials assess intervention effects on specific patient subgroups, ensuring generalizability. However, they are usually only able to generate hypotheses rather than definitive conclusions. This study examined the prevalence and characteristics of post hoc subgroup analysis in oncology.

Methods
We systematically reviewed published subgroup analyses from 2000 to 2022. We included articles presenting secondary, post hoc, or subgroup analyses of interventional clinical trials in oncology, cancer survivorship, or cancer screening, published separately from the original clinical trial publication. We collected cancer type, year of publication, where and how subgroup analyses were reported, and funding.

Results
Out of 16 487 screened publications, 1612 studies were included, primarily subgroup analyses of treatment trials for solid tumors (82%). Medical writers contributed to 31% of articles, and 58% of articles reported conflicts of interest. Subgroup analyses increased significantly over time, with 695 published between 2019 and 2022, compared to 384 from 2000 to 2014. Gastrointestinal tumors (25%) and lymphoid lineage tumors (39%) were the most frequently studied solid and hematological malignancies, respectively. Industry funding and reporting of conflicts of interest increased over time. Subgroup analyses often neglected to indicate their secondary nature in the title. Most authors were from high-income countries, most commonly North America (45%).

Conclusions
This study demonstrates the rapidly growing use of post hoc subgroup analysis of oncology clinical trials, revealing that the majority are supported by pharmaceutical companies, and they frequently fail to indicate their secondary nature in the title. Given the known methodological limitations of subgroup analyses, caution is recommended among authors, readers, and reviewers when conducting and interpreting these studies.
Phase I and II randomized clinical trial of an oral therapeutic vaccine targeting human papillomavirus for treatment of cervical intraepithelial neoplasia 2 and 3
Authors: Kawana Kei , Kobayashi Osamu , Ikeda Yuji , Yahata Hideaki , Iwata Takashi , Satoh Toyomi , Akiyama Azusa , Maeda Daichi , Hori-Hirose Yumiko , Uemura Yukari , Nakayama-Hosoya Kaori , Katoh Kanoko , Katoh Yuki , Nakajima Takahiro , Taguchi Ayumi , Komatsu Atsushi , Asai-Sato Mikiko , Tomita Naoko , Kato Kiyoko , Aoki Daisuke , Igimi Shizunobu , Kawana-Tachikawa Ai , Schust Danny J 
Published: November 2023

Abstract

Background
Although many human papillomavirus (HPV)–targeted therapeutic vaccines have been examined for efficacy in clinical trials, none have been translated into clinical use. These previous agents were mostly administered by intramuscular or subcutaneous injection to induce systemic immunity. We investigated the safety and therapeutic efficacy of an HPV-16 E7-expressing lacticaseibacillus-based oral vaccine.

Methods
In a double-blind, placebo-controlled, randomized trial, a total of 165 patients with HPV-16–positive high-grade cervical intraepithelial neoplasia 2 and 3 were assigned to orally administered placebo or low, intermediate, or high doses of IGMKK16E7 (lacticaseibacillus paracasei expressing cell surface, full-length HPV-16 E7). In the 4 groups, IGMKK16E7 or placebo was administered orally at weeks 1, 2, 4, and 8 postenrollment. The primary outcomes included histopathological regression and IGMKK16E7 safety.

Results
In per-protocol analyses, histopathological regression to normal (complete response) occurred in 13 (31.7%) of 41 high-dose recipients and in 5 (12.5%) of 40 placebo recipients (rate difference = 19.2, 95% confidence interval [CI] = 0.5 to 37.8). In patients positive for HPV-16 only, the clinical response rate was 40.0% (12 of 30) in high-dose recipients and 11.5% (3 of 26) in recipients of placebo (rate difference = 28.5, 95% CI = 4.3 to 50.0). There was no difference in adverse events that occurred in the high-dose and placebo groups (P = .83). The number of HPV-16 E7–specific interferon-γ producing cells within peripheral blood increased with level of response (stable disease, partial, and complete responses; P = .004). The regression to normal (complete response) rates among recipients with high levels of immune response were increased in a dose-dependent manner.

Conclusion
This trial demonstrates safety of IGMKK16E7 and its efficacy against HPV-16–positive cervical intraepithelial neoplasia 2 and 3. IGMKK16E7 is the first oral immunotherapeutic vaccine to show antineoplastic effects.

Trial registration
jRCT2031190034.
The relationship between how agencies work together and coordinated outcomes: a configurational analysis
Authors: Roberts Michael , Milman Anita 
Published: November 2023

Abstract
Coordination mandates are used to steer collective action between local government agencies. When higher levels of government allow agencies to choose how to work together, the organizational forms and institutional arrangements they adopt likely influences their ability to achieve mandated coordinated outcomes. How group-level interactions influence achievement of coordinated outcomes is not well understood. California’s Sustainable Groundwater Management Act (SGMA) provides opportunity to shed light on this topic. SGMA is a state-legislative mandate that requires local agencies who share groundwater basins to undertake groundwater sustainability planning. The mandate affords agencies leeway in deciding how they engage with one another so long as they meet multiple requirements for coordinated outcomes. Drawing on institutional theories of collective action and ethnographic data collected from 2018 to 2022, we employ multi-value Qualitative Comparative Analysis to examine how configurations of organizational forms and institutional arrangements adopted by agencies in eighteen groundwater basins influenced their achievement of coordinated outcomes. Our findings highlight the importance of adopting collaborative institutional arrangements. Yet, the specific configuration of collaborative institutional arrangements varies depending on the type of coordinated outcomes agencies are mandated to achieve. These findings point to the need for mandates to require adoption of collaborative institutional arrangements, the specific configurations of which will be dictated by the requirements of the mandate.
Emerging Risk of Adolescent Depression and Suicide Detected Through Pediatric Primary Care Screening
Authors: Davis Molly , Jones Jason D , Schwartz Karen T G , Dysart Gillian , So Amy , Young Jami F 
Published: November 2023

Abstract

Objective
The goal of the current study was to document patterns of stability and change in adolescent depression and suicide risk detected via universal depression screening in pediatric primary care and to determine who may go on to experience emerging risk.

Methods
Retrospective electronic health record information (sociodemographic data and depression screening results for 2 timepoints) was extracted for adolescents aged 12–17 who attended well-visits between November 15, 2017, and February 1, 2020, in a large pediatric primary care network. A total of 27,335 adolescents with 2 completed depression screeners were included in the current study.

Results
While most adolescents remained at low risk for depression and suicide across the 2 timepoints, others experienced emerging risk (i.e., low risk at time 1 but elevated risk at time 2), decreasing risk (i.e., high risk at time 1 but low risk at time 2) or stable high risk for depression or suicide. Odds of experiencing emerging depression and suicide risk were higher among adolescents who were female (compared to males), Black (compared to White), and had Medicaid insurance (compared to private insurance). Odds of experiencing emerging depression risk were also higher among older adolescents (compared to younger adolescents) as well as adolescents who identified as Hispanic/Latino (compared to non-Hispanic/Latino).

Conclusions
Findings can inform symptom monitoring and opportunities for prevention in primary care.
Locally acquired mpox outbreak in Riyadh, Saudi Arabia: clinical presentation, risk factors and preventive measures
Authors: Dar Nadeem Gul , Alfaraj Sarah H , Alboqmy Khulood N , Amer Hala , Khanum Nazia , Alshakrah Faleh , Abdallah Hassan , Kumar Deva , Alzarzour Shaimaa H , Alzahrani Nojoom A , Arishy Jasser Y , Ahmed Suhair A , Escorpion Vicenta , Lopez Edna , Jedeba Sami , Memish Ziad A 
Published: November 2023

A cluster of 16 locally acquired monkeypox cases in Riyadh, Saudi Arabia, with 10 cases reported engaging in sexual behaviour within 21 days prior to the onset of symptoms, all of whom had heterosexual contact with illegal partners within 1 week before the appearance of symptoms.
Three novel pentavalent meningococcal vaccines
Authors: Steffen Robert , Caumes Eric 
Published: November 2023

Invasive meningococcal disease (IMD) is rare in travellers but associated with high mortality and long-term sequelae. Six serogroups (MenABCWXY) account for more than 90% of IMD. Three pentavalent vaccines are on the horizon: two MenABCWY, both with a 0–6 month schedule, highly immunogenic and well tolerated, and one single-dose MenACWXY.
Carbon Capture, Utilization and Storage tax credits and tax equity project financing in the USA: an assessment under bilateral tax treaties and BEPS actions
Authors: Bacci Alessandro 
Published: November 2023

Abstract
Carbon Capture, Utilization and Storage (CCUS) is a technology for capturing man-made CO2 emissions (carbon emissions) and either storing them, hopefully permanently, underground, generally in suitable saline formations or oil and gas fields, or utilizing them by, eg, converting them into commercially viable products. Because global energy demand and carbon emissions will continue to increase until 2050 by almost 50 per cent, CCUS projects (despite a current difficult business case per metric tonne stored or used), if deployed on a large scale, could help the world to limit global warming to 2.0°C, but preferably 1.5°C, as proposed by the Paris Agreement. For economic reasons, without government support, it will be difficult to have the required number and scale of CCUS projects to tackle global warming. The introduction section of this paper explains how, if we accept the urgency of the Paris Agreement’s thresholds, there is probably not sufficient time for introducing a global emissions trading scheme (ETS) or a global carbon tax, which are considered the two best approaches to reducing carbon emissions. The CCUS legal/regulatory/fiscal approach section analyses, first, the different legal/regulatory/fiscal approaches to CCUS taken by the US and the EU, secondly, the US federal tax credits available for CCUS projects as of May 2022, and thirdly, the powerful incentive mechanism created when the US CCUS tax credits work together with tax equity partnerships. The US CCUS tax credits and tax treaties section, after some initial literature review of tax incentives and how the US CCUS tax credits can be framed within the panoply of tax incentives, focuses on the first research question, ie, on understanding how the US CCUS tax credits interact in a tax treaty environment. The US CCUS tax credits and the BEPS project section plays a similar role in relation to whether the US CCUS tax credits align well with the requirements of the OECD/G20's Base Erosion and Profit Shifting (BEPS) Project, which is aimed at reducing tax avoidance and is more recent in its development. The last section concludes.
Stomatal improvement for crop stress resistance
Authors: Wang Lu , Chang Cheng 
Published: November 2023

Abstract
The growth and yield of crop plants are threatened by environmental challenges such as water deficit, soil flooding, high salinity, and extreme temperatures, which are becoming increasingly severe under climate change. Stomata contribute greatly to plant adaptation to stressful environments by governing transpirational water loss and photosynthetic gas exchange. Increasing evidence has revealed that stomata formation is shaped by transcription factors, signaling peptides, and protein kinases, which could be exploited to improve crop stress resistance. The past decades have seen unprecedented progress in our understanding of stomata formation, but most of these advances have come from research on model plants. This review highlights recent research in stomata formation in crops and its multifaceted functions in abiotic stress tolerance. Current strategies, limitations, and future directions for harnessing stomatal development to improve crop stress resistance are discussed.
Coping After COVID-19: Cognitive Behavioral Skills for Anxiety, Depression, and Adjusting to Chronic Illness
Authors: Jaywant Abhishek , Kanellopoulos Dora , Oberlin Lauren , Cherestal Stephanie , Bueno Castellano Christina , Wilkins Victoria M. 
Published: November 2023

Abstract
Coping After COVID-19: Client Workbook: Cognitive Behavioral Skills for Anxiety, Depression, and Adjusting to Chronic Illness discusses a cognitive behavioral treatment that helps people to cope with persisting symptoms of COVID-19. These symptoms may include sensory and movement challenges, fatigue, and other debilitating changes to the body and mind. People with persisting COVID-19 symptoms may also experience anxiety and depression while struggling to adjust to the changes in their everyday life and uncertainties about the future. Moreover, adjustment difficulties, anxiety, and depression can result in poor adherence to medical treatments, contribute to disability, and negatively affect overall quality of life. The self-assessments, homework exercises, and worksheets presented in this program help people become active participants in their treatment.