bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative Extracellular Brain Free-Water Changes for Older Adults Electing Total Knee Arthroplasty with General versus Spinal Anesthesia: A Pilot Study
Authors: Tanner Jared J. , Amin Manish , Dion Catherine , Parvataneni Hari K. , Mareci Thomas , Price Catherine C. 
Published: November 2023

Background: Recent research shows that older adults electing to undergo total knee arthroplasty with general anesthesia have a pre- to postoperative acute increase in molecular free-water within their cerebral white matter. It is unknown if this change is similar for individuals who elect spinal anesthesia methods. Objective: To explore white matter microstructural changes in a pilot sample of older adults undergoing total knee arthroplasty and receiving general or spinal anesthesia. Methods: We assessed acute perioperative changes in brain white matter free-water in a limited number of older adults electing total knee arthroplasty under spinal anesthesia ( n = 5) and matched groups of older adults who received general anesthesia ( n = 5) or had no surgery ( n = 5). Patterns of free-water changes were also compared in the larger group of older adults electing total knee arthroplasty under general anesthesia ( n = 61) and older adults with chronic knee pain who received no surgical intervention ( n = 65). Results: Our pilot results suggest older adults receiving general anesthesia had pre- to post-surgery free-water increases extensively throughout their white matter whereas those receiving spinal anesthesia appeared to have less consistent free-water increases. Conclusions: Our pilot results possibly suggest different patterns of perioperative brain white matter free-water changes based on anesthetic approach. We recommend future, larger studies to further examine the effects of anesthetic approach on perioperative brain free-water. The results of our study have potential implications for acute and chronic cognitive changes, perioperative complications, neurodegenerative processes including Alzheimer’s disease, and understanding neuroinflammation.
Life-Sustaining Treatments Among Medicare Beneficiaries with and without Dementia at the End of Life
Authors: Zhu Yingying , Olchanski Natalia , Cohen Joshua T. , Freund Karen M. , Faul Jessica D. , Fillit Howard M. , Neumann Peter J. , Lin Pei-Jung 
Published: November 2023

Background: Older adults with dementia including Alzheimer’s disease may have difficulty communicating their treatment preferences and thus may receive intensive end-of-life (EOL) care that confers limited benefits. Objective: This study compared the use of life-sustaining interventions during the last 90 days of life among Medicare beneficiaries with and without dementia. Methods: This cohort study utilized population-based national survey data from the 2000-2016 Health and Retirement Study linked with Medicare and Medicaid claims. Our sample included Medicare fee-for-service beneficiaries aged 65 years or older deceased between 2000 and 2016. The main outcome was receipt of any life-sustaining interventions during the last 90 days of life, including mechanical ventilation, tracheostomy, tube feeding, and cardiopulmonary resuscitation. We used logistic regression, stratified by nursing home use, to examine dementia status (no dementia, non-advanced dementia, advanced dementia) and patient characteristics associated with receiving those interventions. Results: Community dwellers with dementia were more likely than those without dementia to receive life-sustaining treatments in their last 90 days of life (advanced dementia: OR = 1.83 [1.42–2.35]; non-advanced dementia: OR = 1.16 [1.01–1.32]). Advance care planning was associated with lower odds of receiving life-sustaining treatments in the community (OR = 0.84 [0.74–0.96]) and in nursing homes (OR = 0.68 [0.53–0.86]). More beneficiaries with advanced dementia received interventions discordant with their EOL treatment preferences. Conclusions: Community dwellers with advanced dementia were more likely to receive life-sustaining treatments at the end of life and such treatments may be discordant with their EOL wishes. Enhancing advance care planning and patient-physician communication may improve EOL care quality for persons with dementia.
Paving the Way for Alzheimer’s Disease Prevention: A Systematic Review of Global Open-Access Neuroimaging Datasets in Healthy Individuals
Authors: Ly Maria , Yu Gary Z. , Chwa Won Jong , Raji Cyrus A. 
Published: November 2023

Background: Given the advent of large-scale neuroimaging data-driven endeavors for Alzheimer’s disease, there is a burgeoning need for well-characterized neuroimaging databases of healthy individuals. With the rise of initiatives around the globe for the rapid and unrestricted sharing of data resources, there is now an abundance of open-source neuroimaging datasets available to the research community. However, there is not yet a systematic review that fully details the demographic information and modalities actually available in all open access neuroimaging databases around the globe. Objective: This systematic review aims to provide compile a list of MR structural imaging databases encompassing healthy individuals across the lifespan. Methods: In this systematic review, we searched EMBASE and PubMed until May 2022 for open-access neuroimaging databases containing healthy control participants of any age, race, with normal development and cognition having at least one structural T1-weighted neuroimaging scan. Results: A total of 403 databases were included, for up to total of 48,268 participants with all available demographic information and imaging modalities detailed in Supplementary Table 1. There were significant trends noted when compiling normative databases for this systematic review, notably that 11.7% of databases included reported ethnicity in their participants, with underrepresentation of many socioeconomic groups globally. Conclusions: As efforts to improve primary prevention of AD may require a broader perspective including increased relevance of earlier stages in life, and strategies in addressing modifiable risk factors may be individualized to specific demographics, improving data characterization to be richer and more rigorous will greatly enhance these efforts.
Elevated Pure Tone Thresholds Are Associated with Altered Microstructure in Cortical Areas Related to Auditory Processing and Attentional Allocation
Authors: McEvoy Linda K. , Bergstrom Jaclyn , Hagler Donald J. , Wing David , Reas Emilie T. 
Published: November 2023

Background: Hearing loss is associated with cognitive decline and increased risk for Alzheimer’s disease, but the basis of this association is not understood. Objective: To determine whether hearing impairment is associated with advanced brain aging or altered microstructure in areas involved with auditory and cognitive processing. Methods: 130 participants, (mean 76.4±7.3 years; 65% women) of the Rancho Bernardo Study of Healthy Aging had a screening audiogram in 2003–2005 and brain magnetic resonance imaging in 2014–2016. Hearing ability was defined as the average pure tone threshold (PTA) at 500, 1000, 2000, and 4000 Hz in the better-hearing ear. Brain-predicted age difference (Brain-pad) was calculated as the difference between brain-predicted age based on a validated structural imaging biomarker of brain age, and chronological age. Regional diffusion metrics in temporal and frontal cortex regions were obtained from diffusion-weighted MRIs. Linear regression analyses adjusted for age, gender, education, and health-related measures. Results: PTAs were not associated with brain-PAD (β= 0.09; 95% CI: –0.084 to 0.243; p = 0.34). PTAs were associated with reduced restricted diffusion and increased free water diffusion primarily in right hemisphere temporal and frontal areas (restricted diffusion: βs = –0.21 to –0.30; 95% CIs from –0.48 to –0.02; ps < 0.03; free water: βs = 0.18 to 0.26; 95% CIs 0.01 to 0.438; ps < 0.04). Conclusions: Hearing impairment is not associated with advanced brain aging but is associated with differences in brain regions involved with auditory processing and attentional control. It is thus possible that increased dementia risk associated with hearing impairment arises, in part, from compensatory brain changes that may decrease resilience.
Exploring Students’ Readiness in Blended Leraning in EFL Context
Authors: Larasaty Gina , Oktaviani Ginsa 
Published: November 2023

Nowadays, technology is widely viewed as a platform in EFL teaching that integrates online and offline. Although much of the study investigates the Blended Learning method in EFL teaching, relatively little empirical evidence reports students' readiness for Blended Learning. To fill this gap, this study is aimed to know how students' readiness for Blended Learning is situated in the Senior High School context. Grounded in qualitative research with survey design, this survey is distributed to 108 students from SMAN l Indramayu in the academic year 2021 / 2022. This research showed that students have low readiness levels in the English language Blended Learning in which they scored 2.71 out of 4.00. These indicate that senior high school students are not ready to learn English using Blended Learning. This can be seen from the students' attitude. The student's attitude showed that 1). most students want to access the teaching materials and the English lessons without limits of time and place. 2). most students felt that they got bored when studying online. 3). most of them stated they missed assignment due dates in an online learning activity. 4). most students said they like the fast feedback when they meet their teacher in person. However, they have a positive opinion Web is a helpful platform for learning.
Prosedur Registrasi Online Pertunjukan Perempuan-Perempuan Pilihan Oleh PT Kayangan Abadi Andalan
Authors: Darmawan Mutia Nanda , Kongrat Etty 
Published: November 2023

Registrasi merupakan salah satu unsur penting dalam penyelenggaraan pertunjukan karena registrasi akan menjadi kesan pertama penonton terhadap pertunjukan yang diseleng-garakan. Penelitian ini membahas mengenai prosedur pra registrasi dan registrasi ulang serta hambatan dan solusi yang diberikan selama registrasi dalam pertunjukan Perempuan-Perempuan Pilihan dilakukan. Tujuan dari penelitian ini adalah untuk mengetahui prosedur pra registrasi dan registrasi ulang serta untuk mengetahui hambatan dan solusi yang dilakukan selama registrasi dilaksanakan. Metode pengumpulan data pada penilitian ini menggunakan metode observasi dan metode dokumentasi. Metode analisis data menggunakan analisis kualitatif deskriptif procedural, dimana pengolahan data dilakukan dengan menguraikan data dalam bentuk kalimat teratur, runtun, logis, dan efektif. Hasil penelitian menunjukan bahwa registrasi pada pertunjukan Perempuan-Perempuan Pilihan, yaitu: satu, pra registrasi yang dimulai dengan mempersiapkan platform caket.org, calon penonton melakukan registrasi melalui platform caket.org, sampai dengan calon penonton mendapatkan e-ticket; dua, registrasi ulang, penonton menunjukan e-ticket yang mereka miliki kepada staff registrasi dan staff registrasi akan melakukan scan barcode untuk melakukan pengecekkan data.

Kata Kunci: Pertunjukan, Pra Registrasi, Registrasi Ulang
Penerapan Tata Kelola Lembaga Perkreditan Desa Pada Desa Adat Ketewel Kecamatan Sukawati
Authors: Suandari Anak Agung Mas , Sudiana I Wayan 
Published: November 2023

ABSTRACT
Corporate Governance is a set of structured processes used to manage and direct or lead a business with the intention of increasing corporate value and business continuity. The purpose of this research is to find out how the principles of corporate governance are applied to the LPD in Ketewel Traditional Village. The method used in this research is descriptive qualitative method. The results of the study show that the implementation of village credit institution governance at the Ketewel Traditional Village LPD has been going quite well, by implementing the five GCG principles, but there are still indicators of GCG principles that have not been maximized, namely the principle of accountability. The Ketewel Traditional Village LPD has not optimally conducted training and seminars for employees, the training and seminars that have been conducted so far are still general and internal in nature. In increasing competitiveness outside with other companies, in the future the Ketewel Traditional Village LPD in training and seminars needs to be held externally so that employees can learn new things and add various insights and knowledge outside the company to enhance the development and progress of the company.
Reference-phantom-free imaging of local attenuation coefficient in synthetic transmit aperture ultrasound imaging
Authors: Abdalla Khalid , Zhao Na , Xu Yuan 
Published: November 2023

<p>The attenuation coefficient slope(ACS) is an essential property of biological tissues. Most of the present ACS estimation methods use spectrum-based approaches in B-mode imaging and need a reference phantom. A method to map ACS without a reference phantom is proposed in Synthetic Transmit Aperture ultrasound imaging. The diffraction effect in ACS estimation is studied. In this paper, the transducer bandwidth was divided into overlapping sub-bands, and each sub-band was used to reconstruct an image and yield the corresponding sub-band attenuation coefficient to obtain ACS. The feasibility of the proposed method was demonstrated in numerical simulations and experiments. </p>
SITUS PENINGGALAN SEJARAH PRASASTI PASIR PANJANG DI MERAL BARAT TANJUNG BALAI KARIMUN
Authors: Yuliani Yuliani , Arnesih Arnesih 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui situs sejarah peninggalan Prasasti Pasir Panjang di Meral Barat Tanjung Balai Karimun. Karimun berada di bawah kekuasaan kerajaan Sriwijaya dan pada masa itu pengaruh ajaran Hindu dan Buddha mulai masuk ke Pulau Karimun. Masyarakat mengakui bahwa umat Hindu-Budha pernah singgah ke Tanjung Balai Karimun dan dibuktikan dengan adanya bukti prasasti pasir panjang. Karimun dahulu berada di bawah kekuasaan kerajaan Sriwijaya hingga keruntuhannya pada abad ke-13, dan pada masa itu pengaruh ajaran Hindu dan Buddha mulai masuk ke Pulau Karimun. Banyak tempat-tempat peninggalan sejarah di Tanjung Balai Karimun, seperti, gedung nasional karimun, keramat tanjung gelam, makam badang moyang seraga serta prasasti pasir panjang
PENERAPAN METODE PICTURE AND PICTURE UNTUK MENINGKATKAN HASIL BELAJAR IPS TERPADU SISWA KELAS IX SMPN 25 BATAM T.A 2021/2022
Authors: YANTI FITRI , Mila Nurmila 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar siswa dalam pembelajaran IPS Terpadu menggunakan metode Picture and Picture di SMP Negeri 25 Batam T.A 2021/2022. Jenis penelitian ini adalah penelitian kuantitatif dengan metode eksperimen, quasi eksperimental research. Populasi dalam penelitian ini adalah siswa kelas IX IPS SMP Negeri 25 Batam. Teknik sampling dalam penelitian ini menggunakan non probability sampling, yaitu dengan menggunakan purposive sampling. Instrumen penelitian yang digunakan berbentuk soal pilihan ganda yang telah diuji validitas dan reabilitasnya. Hasil penelitian menunjukkan penerapan metode Picture and Picture efektif terhadap hasil belajar IPS Terpadu siswa kelas IX SMPN 25 Batam, terlihat dari peningkatan hasil belajar siswa diperoleh hasil belajar siswa dengan nilai terbesar siswa kelas eksperimen (Xmax) adalah 100 dan nilai terkecil (Xmin) adalah 75 dengan mean 82.3. Sedangkan pada kelas kontrol, nilai terbesar siswa (Xmax) adalah 90 dan nilai terkecil (Xmin) adalah 60, dengan mean 74.5 yang menandakan presentase hasil belajar belum mencapai KKM 75.00.
PENGARUHiLIKUIDITAS DANiSOLVABILITASiTERHADAP KINERJAiKEUANGAN PTiGUDANG GARAMiTBK PERIODE 2017-2021
Authors: Arumsari Yasinta Citra 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pengaruh likuiditas dan solvabilitas terhadap kinerja keuangan perusahaan. Dalam penelitian ini variabel independent adalah likuiditas yang menggunakan perhitungan rasio CR (Current Ratio) dan solvabilitas yang menggunakan perhitungan DER (Debt to Equity Ratio). Sedangkan untuk variabel dependen adalah kinerja keuangan dengan menggunakan perhitungan rasio ROE (Return on Equity). Data yang digunakan berupa data sekunder laporan keuangan tahunan. Metode penelitan yang diterapkan yakni penelitian kuantitatif. Populasi dalam penelitian ini yakni laporan keuangan PT Gudang Garam Tbk serta mengambil sampel berupa neraca dan laporan laba rugi PT Gudang Garam Tbk periode 2017-2021. Teknik analisis data menggunakan Uji Analisis Asumsi Klasik, Analisis Koefisien Determinasi(R2) dan Analisis Regresi Linier Berganda. Hasil penelitian menunjukkan angka signifikansi likuiditas yang diproksikan dengan CR (Current Ratio) sebesar 0,299. Angka signifikansi solvabilitas yang diproksikan dengan DER (Debt to Equity Ratio) sebesar 0,272. Besarnya angka tersebut melebihi dari standar taraf signifikansi yakni 0,05. Hal tersebut dapat diartikan bahwa likuiditas dan solvabilitas tidak berpengaruh signifikan terhadap kinerja keuangan perusahan.
Where do differences in theory of mind development come from? An agent-based model of social interaction and theory of mind
Authors: Yu Chi-Lin , Wellman Henry M. 
Published: November 2023

IntroductionWhere do individual differences in theory of mind (ToM) development come from? This is an open-ended issue in developmental psychology. Correlational research suggests social interaction as a cause. However, causal experiments controlling children's extended, real-life social interactions are impractical and unethical, so the links between social interaction and ToM remain only indirectly demonstrated. To shed light on how social interaction, in different degrees and forms, may influence ToM development, we conducted computational experiments using agent-based modeling.MethodsTo begin with, we simulated agents (hypothetically, children) and assigned them to 10 groups, where each group was manipulated to allow a different amount of social interaction, from 1 to 10. Within each group, agents randomly roamed and encountered one another and then interacted. If these interactions continued long enough, agents' ToM probabilistically improved.ResultsAs expected, results showed that the amount of social interaction strongly influenced how fast agents developed ToM, where more social interaction led to more rapid development. Given this confirmation of the assumed link, we more focally explored how other factors—such as having a prior, established social network or agents' network centrality—could influence the social interaction-ToM link. Then, we tested our model against real-world data from 84 deaf children and showed that our modeling results could explain the social interaction-ToM link observed in deaf children.DiscussionThese demonstrations illustrate how individual differences in ToM development may emerge and offer an explanation specifying a crucial mechanism for how all humans achieve ToM—faster or with delay—through processes of social interaction.
Characteristics of specialists treating hypothyroid patients: the “THESIS” collaborative
Authors: Žarković Miloš , Attanasio Roberto , Nagy Endre V. , Negro Roberto , Papini Enrico , Perros Petros , Cohen Chagit Adler , Akarsu Ersin , Alevizaki Maria , Ayvaz Göksun , Bednarczuk Tomasz , Berta Eszter , Bodor Miklos , Borissova Anna Maria , Boyanov Mihail , Buffet Camille , Burlacu Maria-Cristina , Ćirić Jasmina , Díez Juan J. , Dobnig Harald , Fadeyev Valentin , Field Benjamin C. T. , Fliers Eric , Frølich Jacob Stampe , Führer Dagmar , Galofré Juan Carlos , Hakala Tommi , Jiskra Jan , Kopp Peter , Krebs Michael , Kršek Michal , Kužma Martin , Lantz Mikael , Lazúrová Ivica , Leenhardt Laurence , Luchytskiy Vitaliy , McGowan Anne , Melo Miguel , Metso Saara , Moran Carla , Morgunova Tatyana , Mykola Tronko , Beleslin Biljana Nedeljković , Niculescu Dan Alexandru , Perić Božidar , Planck Tereza , Poiana Catalina , Puga Francisca Marques , Robenshtok Eyal , Rosselet Patrick , Ruchala Marek , Riis Kamilla Ryom , Shepelkevich Alla , Unuane David , Vardarli Irfan , Visser W. Edward , Vrionidou Andromachi , Younes Younes R. , Yurenya Elena , Hegedüs Laszlo 
Published: November 2023

IntroductionThyroid specialists influence how hypothyroid patients are treated, including patients managed in primary care. Given that physician characteristics influence patient care, this study aimed to explore thyroid specialist profiles and associations with geo-economic factors.MethodsThyroid specialists from 28 countries were invited to respond to a questionnaire, Treatment of Hypothyroidism in Europe by Specialists: an International Survey (THESIS). Geographic regions were defined according to the United Nations Statistics Division. The national economic status was estimated using World Bank data on the gross national income per capita (GNI per capita).Results5,695 valid responses were received (response rate 33·0%). The mean age was 49 years, and 65·0% were female. The proportion of female respondents was lowest in Northern (45·6%) and highest in Eastern Europe (77·2%) (p &lt;0·001). Respondent work volume, university affiliation and private practice differed significantly between countries (p&lt;0·001). Age and GNI per capita were correlated inversely with the proportion of female respondents (p&lt;0·01). GNI per capita was inversely related to the proportion of respondents working exclusively in private practice (p&lt;0·011) and the proportion of respondents who treated &gt;100 patients annually (p&lt;0·01).DiscussionTHESIS has demonstrated differences in characteristics of thyroid specialists at national and regional levels, strongly associated with GNI per capita. Hypothyroid patients in middle-income countries are more likely to encounter female thyroid specialists working in private practice, with a high workload, compared to high-income countries. Whether these differences influence the quality of care and patient satisfaction is unknown, but merits further study.