bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of wiener nonlinear systems with measurement noises utilizing correlation analysis and Kalman filter
Authors: Li Feng , Qian Shengyi , He Naibao , Li Bo 
Published: February 2024

AbstractThis paper is concerned with parameter estimation of Wiener systems with measurement noises employing correlation analysis method and adaptive Kalman filter. The presented Wiener system consists of two series blocks, that is, a dynamic block represented by auto‐regressive moving average (ARMA) model, and static nonlinear block established by neural fuzzy model. Aim at estimating separately the two blocks, the separable signals are introduced. First, applying the separable signals to decouple the identification of linear dynamic block from that of static nonlinear block, then ARMA model parameters are estimated employing correlation function‐based least squares principle. Moreover, aiming at handle with error caused by colored measurement noise, adaptive Kalman filter technique and cluster method are introduced to estimate parameter of the nonlinear block and noises model, enhancing parameter estimation precision. The accuracy and applicability of estimated scheme presented are verified through numerical simulation and nonlinear process, the results demonstrate that it is feasible for estimating the Wiener systems in the presence of colored measurement noises.
4‐Furfuryloxymethyl‐1,2,3‐triazol‐1‐yl‐acetohydrazide Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors: Synthesis, Characterization and Comprehensive Biological Activity Studies
Authors: Şenol Halil 
Published: February 2024

AbstractThis study focused on the synthesis and evaluation of the biological activity of ten novel acetohydrazide hybrid derivatives, having furfuryloxy‐1,2,3‐triazole ring. All the target compounds were tested in vitro and in silico for their inhibitory potential against key enzymes: hAChE, hBChE, hCAI, and hCAII, all involved in significant physiological processes. Remarkably, two compounds, namely (E)‐2‐(4‐((furan‐2‐ylmethoxy)methyl)‐1H‐1,2,3‐triazol‐1‐yl)‐N′‐(4‐hydroxy‐3‐methoxybenzylidene)acetohydrazide (9) and (E)‐N′‐(4‐chlorobenzylidene)‐2‐(4‐((furan‐2‐ylmethoxy)methyl)‐1H‐1,2,3‐triazol‐1‐yl)acetohydrazide (11), exhibited strong inhibitory activity. Compound 9 emerged as the top‐performing inhibitor for both hAChE (IC50 of 0.23 μM) and hBChE (IC50 of 0.74 μM). Additionally, compounds 9 and 11 displayed potent inhibitory effects on hCAI and hCAII, with IC50 values of 0.18 μM and 0.15 μM, respectively. Furthermore, in silico studies provided valuable insights into the interaction mechanisms and stability of the ligand‐protein complexes. Compound 9 demonstrated strong binding scores of −12.063 kcal/mol for hAChE and −9.359 kcal/mol for hBChE, while Compound 11 exhibited substantial scores of −7.040 kcal/mol for hCAI and −8.216 kcal/mol for hCAII. In conclusion, they stand out as promising inhibitors of hAChE, hBChE, hCAI and hCAII enzymes. Their inhibitory activity, supported by low IC50 values, indicated their potential to inhibit enzymes associated with neurological and metabolic processes.
Bird's Nest‐Shaped Sb2WO6/D‐Fru Composite for Multi‐Stage Evaporator and Tandem Solar Light‐Heat‐Electricity Generators
Authors: Wan Yanfen , Hu Yingfei , Tu Hongyu , Zhuang Wenbo , Geng Xuemin , Zhang Tian , Zhang Jinghao , Wen Ming , Yang Peng 
Published: February 2024

AbstractHerein, an integrated solar‐thermal‐power protocol is presented at a micro‐nanoscopic level to maximize the energy utilization efficiency involving utilization period and utilization patterns, and the nexus of freshwater production and nanogeneration is realized. This sophisticated vaporization device is constructed with the merits of thermally confined evaporation space in favor of recycling latent heat of condensation and optimizing light absorption based on the local sunlight angle of incidence. Inspired by a bird's nest, Sb2WO6/D‐Fructose composites are prepared as photothermal absorbers to achieve a superior water evaporation rate of 2.78 kg m−2 h−1 in the Multi‐stage evaporator. In addition, a synergistic tandem photo thermal‐electric device with a combination of solar‐driven water evaporation and further waterflow‐driven hydrovoltaic generation, which can output a stable voltage of up to 360.8 mV with effective utilization of steam energy and a limited water source, is exploited. Such integrated configurations pave a pathway for clean water production and renewable power generation simultaneously toward energy issues.
Highly Sensitive Wearable Sensor Based on (001)‐Orientated TiO2 for Real‐Time Electrochemical Detection of Dopamine, Tyrosine, and Paracetamol
Authors: Zhang Tianyao , Zhu Jia , Xie Maowen , Meng Ke , Yao Guang , Pan Taisong , Gao Min , Cheng Huanyu , Lin Yuan 
Published: February 2024

AbstractThe concentration of dopamine (DA) and tyrosine (Tyr) reflects the condition of patients with Parkinson's disease, whereas moderate paracetamol (PA) can help relieve their pain. Therefore, real‐time measurements of these bioanalytes have important clinical implications for patients with Parkinson's disease. However, previous sensors suffer from either limited sensitivity or complex fabrication and integration processes. This work introduces a simple and cost‐effective method to prepare high‐quality, flexible titanium dioxide (TiO2) thin films with highly reactive (001)‐facets. The as‐fabricated TiO2 film supported by a carbon cloth electrode (i.e., TiO2–CC) allows excellent electrochemical specificity and sensitivity to DA (1.390 µA µM−1 cm−2), Tyr (0.126 µA µM−1 cm−2), and PA (0.0841 µA µM−1 cm−2). More importantly, accurate DA concentration in varied pH conditions can be obtained by decoupling them within a single differential pulse voltammetry measurement without additional sensing units. The TiO2–CC electrochemical sensor can be integrated into a smart diaper to detect the trace amount of DA or an integrated skin‐interfaced patch with microfluidic sampling and wireless transmission units for real‐time detection of the sweat Try and PA concentration. The wearable sensor based on TiO2–CC prepared by facile manufacturing methods holds great potential in the daily health monitoring and care of patients with neurological disorders.
Certifiably employable? Occupational regulation and unemployment duration
Authors: Kukaev Ilya , Timmons Edward J. 
Published: February 2024

AbstractOccupational regulation is a labor market institution that has received a growing amount of attention. However, there is a gap in the literature regarding the relationship between occupational credentials and unemployment duration in the United States. Thus, we propose a random search model to explain differences in unemployment duration resulting from heterogeneous effects from licenses and certification. Our model predicts that an occupational credential with a stronger signaling/human capital effect results in a shorter individual unemployment duration. To estimate the relationship between occupational credentials and spells of unemployment, we perform a survival analysis using panel data from the Survey of Income and Program Participation (SIPP) for the years 2013–2019. We find that both licensing and certification are associated with reductions in unemployment spells for Black males that are similar in magnitude. Our results provide some suggestive guidance to policymakers since certification is less costly and not mandatory like occupational licensing.
Optimization of Synthesis of Cassava Starch Phosphates by Response Surface Methodology and Characterization of the Modified Starches
Authors: Joseph Divya , Jyothi Alummoottil N. , Sreekumar Janardanan 
Published: February 2024

AbstractCassava starch has not been widely exploited in modified starch sector, despite its beneficial and peculiar properties including bland taste and flavor, easy extractability, and good paste clarity. In this study, cassava starch is phosphorylated using sodium tripolyphosphate (STPP) and sodium trimetaphosphate (STMP) at different pH levels according to a central composite design and optimized reaction conditions for maximum phosphorus content. The granule morphology, crystalline pattern, pasting properties, physicochemical properties, and in vitro starch digestibility of the modified starches are determined. The reaction conditions have significant effects on the P content. The highest P content (0.160%) is obtained for the sample synthesized using 8% of STMP and 4% of STPP (based on starch dry weight) at a pH of 9.0. X‐ray diffraction analysis revealed no noticeable change in crystalline properties of the modified starches in comparison to native starch. Samples with lower %P have similar granule morphology as the native starch, whereas at higher levels of P, granule rupture and agglomeration are noticed. Wide differences in the pasting and swelling properties are observed among the modified starches. Crosslinked starches formed at higher levels of pH show highly reduced paste viscosity and restricted in vitro starch digestibility.
Report of the Nomenclature Committee for Fossils: 17
Authors: Herendeen Patrick S. 
Published: February 2024

SummaryThe following four generic names are recommended for conservation: Dipterocarpoxylon with a conserved type against Hippocrateoxylon, Dryobalanoxylon against Naucleoxylon, Shoreoxylon against Bredaea and Grewioxylon, and Myrtophyllum Heer (fossil Angiosperms) with a conserved type against Myrtophyllum Turcz. The following one species name is recommended for conservation: Quercus pacifica Nixon & C.H. Mull. against Q. pacifica Knowlt.
Inclusive learning communities: An English learner framework for all educators
Authors: Teemant Annela , Upton Thomas , Sherman Brandon J. 
Published: February 2024

AbstractEducators in many countries must meet the educational needs of students who are not fluent in the language of instruction. Professional learning focused on incremental or individual teacher change has failed to improve student learning trajectories (Cuban, 2013; Gorski & Zenkov, 2014). This article explores Brookfield's (2012) critical articulation of Mezirow's (2012) adult learning theory to support the complex and radical transformation needed from all educators—not just language specialists—to improve classroom learning and schooling. We present the inclusive learning communities framework, with conceptual and pedagogical growth targets, guiding a seven‐course English as a New Language Certification program for PreK‐12 preservice and in‐service teachers working with English learners (ELs) in general education and EL specialist classrooms. The conceptual and pedagogical elements leverage critical transformative learning theory to reframe educators' individual beliefs and practices while developing their collective capacity to challenge oppressive ideologies and systems in pursuit of equity. We conclude that radical improvement in EL outcomes requires all EL teacher educators to plan and evaluate university coursework programmatically in ways that demonstrate real‐world change.
Baicalein targets STMN1 to inhibit the progression of nasopharyngeal carcinoma via regulating the Wnt/β‐catenin pathway
Authors: Li Zheng , Cai Xiaohang 
Published: February 2024

AbstractBackgroundsNasopharyngeal carcinoma is a common malignancy in the head and neck. Baicalein has been reported to exert the anticancer effects on various cancers. In this study, our aim was to explore the function of baicalein in the development of nasopharyngeal carcinoma and further investigate the potential underlying mechanisms.MethodsCell Counting Kit (CCK)‐8 assay, EdU assay, sphere formation assay, flow cytometry, and transwell invasion assay were conducted to determine cell proliferation, stemness, apoptosis, and invasion, respectively. Western blot was performed to examine the protein levels of PCNA, MMP9, STMN1, β‐catenin, and Wnt3A. The mRNA level of STMN1 was assessed using real‐time quantitative polymerase chain reaction (RT‐qPCR). Xenograft tumor model was carried out to evaluate the effects of baicalein on tumor growth in vivo. Immunohistochemistry (IHC) assay was used to detect the levels of PCNA, MMP9, and STMN1 in tumor tissues from mice.ResultsBaicalein significantly induced cell apoptosis and impeded cell proliferation, invasion, and stemness of nasopharyngeal carcinoma cells. STMN1 was highly expressed in nasopharyngeal carcinoma, and baicalein could directly downregulate STMN1 expression. STMN1 knockdown hampered the progression of nasopharyngeal carcinoma cells. Moreover, the effects of baicalein on cell proliferation, stemness, invasion, and apoptosis in nasopharyngeal carcinoma cells were harbored by STMN1 overexpression. Baicalein regulated STMN1 to inhibit the activation of the Wnt/β‐catenin pathway. SKL2001, an agonist of the Wnt/β‐catenin pathway, could reverse the effects of STMN1 knockdown on the progression of nasopharyngeal carcinoma. In addition, baicalein markedly impeded tumor growth in vivo.ConclusionBaicalein regulated the STMN1/Wnt/β‐catenin pathway to restrain the development of nasopharyngeal carcinoma.
BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance
Authors: Fujimura Masatake , Unoki Takamitsu 
Published: February 2024

AbstractMethylmercury (MeHg) causes selective neuronal damage to cerebrocortical neurons (CCNs) in the central nervous system, but not to hippocampal neurons (HiNs), which are highly vulnerable to neurodegenerative diseases. In our previous study using cultured rat neurons, we performed a comprehensive gene expression analysis and found that the brain‐derived neurotrophic factor (BDNF), a neurotrophin (NT), was specifically expressed in HiNs. Therefore, to elucidate the causal factors of MeHg toxicity resistance in HiNs, we conducted a comparative study of the protein expression and function of several NTs, including BDNF, using CCNs showing vulnerability to MeHg toxicity and HiNs showing resistance. BDNF was specifically expressed in HiNs, whereas nerve growth factor was barely detectable in either neuron type. In addition, other NTs, NT3 and NT4/5, were expressed in small but nearly equal amounts in both neuron types. Furthermore, among the various pathways involved in MeHg neurotoxicity, the p44/42 MAPK pathway was specifically activated in HiNs, even without MeHg treatment. siRNAs were used to reduce NTs in both neuron types. Only a specific reduction in BDNF attenuated the resistance to MeHg toxicity and p44/42 MAPK activation in HiNs. In addition, the external addition of BDNF and NT4/5, which act on the same tyrosine receptor kinase (Trk), TrkB, suppressed MeHg neurotoxicity in both neuron types. These results suggest that BDNF, expressed specifically in HiNs, is involved in the resistance to MeHg neurotoxicity via TrkB. Additionally, the activation of the p44/42 MAPK pathway may contribute to the inhibitory effect of BDNF on MeHg neurotoxicity.
Fludioxonil induces cardiotoxicity via mitochondrial dysfunction and oxidative stress in two cardiomyocyte models
Authors: Seong Su‐Min , Go Ryeo‐Eun , Lee Hong Kyu , Choi Kyung‐Chul 
Published: February 2024

AbstractFludioxonil (Flu) is a phenylpyrrole fungicide and is currently used in over 900 agricultural products globally. Flu possesses endocrine‐disrupting chemical‐like properties and has been shown to mediate various physiological and pathological changes, such as apoptosis and differentiation, in diverse cell lines. However, the effects of Flu on cardiomyocytes have not been studied so far. The present study investigated the effects of Flu on mitochondria in AC16 human cardiomyocytes and H9c2 rat cardiomyoblasts. Flu decreased cell viability in a water‐soluble tetrazolium assay and mediated morphological changes suggestive of apoptosis in AC16 and H9c2 cells. We confirmed that annexin V positive cells were increased by Flu through annexin V/propidium iodide staining. This suggests that the decrease in cell viability due to Flu may be associated with increased apoptotic changes. Flu consistently increased the expression of pro‐apoptotic markers such as Bcl‐2‐associated X protein (Bax) and cleaved‐caspase 3. Further, Flu reduced the oxygen consumption rate (OCR) in AC16 and H9c2 cells, which is associated with decreased mitochondrial membrane potential (MMP) as observed through JC‐1 staining. In addition, Flu augmented the production of mitochondrial reactive oxygen species, which can trigger oxidative stress in cardiomyocytes. Taken together, these results indicate that Flu induces mitochondrial dysregulation in cardiomyocytes via the downregulation of the OCR and MMP and upregulation of the oxidative stress, consequently resulting in the apoptosis of cardiomyocytes. This study provides evidence of the risk of Flu toxicity on cardiomyocytes leading to the development of cardiovascular diseases and suggests that the use of Flu in agriculture should be done with caution and awareness of the probable health consequences of exposure to Flu.
Thermodynamics with conformal Killing vector in the charged Vaidya metric
Authors: Koh Seoktae , Park Miok , Sherif Abbas M. 
Published: February 2024

Abstract
We investigate the charged Vaidya spacetime with conformal symmetry by classifying the horizons and finding its connection to Hawking temperature. We find a conformal Killing vector whose existence requires the mass and electric charge functions to be proportional, as well as linear in time. Solving the Killing equations for the conformally transformed metric from the linear charged Vaidya metric yields the required form of the conformal factor. From the vanishing of the norm of the conformal Killing vector, we find three conformal Killing horizons which, under the transformation, are mapped to the Killing horizons of the associated static spacetime, if the spherical symmetry is maintained. We find that the conformal factor is not uniquely determined, but can take any function of the ratio of the radial coordinate to the dynamical mass. As an example, we illustrate a static spacetime with our choice of the conformal factor and explicitly show that the surface gravity of the conformal Killing horizons, which is conformally invariant, yield the expected Hawking temperature in the static spacetime. This static black hole spacetime contains a cosmological horizon, but it is not asymptotically de Sitter. We also investigate the case when the mass parameter is equal to the constant electric charge. While in this case the standard pair of horizons, the loci of the time component of the metric, degenerate, the conformal Killing horizons do not degenerate. This therefore leads to a non-zero Hawking temperature in the associated static spacetime.
Association of SGLT2 inhibitor dapagliflozin with risks of acute kidney injury and all-cause mortality in acute myocardial infarction patients
Authors: Cai Dabei , Chen Qianwen , Mao Lipeng , Xiao Tingting , Wang Yu , Gu Qingqing , Wang Qingjie , Ji Yuan , Sun Ling 
Published: February 2024

Abstract
Objective
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have well-documented effects in reducing hospitalization or cardiovascular mortality, while the association of SGLT2 inhibitor dapagliflozin (DAPA) and the risk of acute kidney injury (AKI) in acute myocardial infarction (AMI) patients has not been comprehensively investigated. Therefore, we aimed to assess the association between DAPA and AKI risk in AMI patients after percutaneous coronary intervention (PCI) therapy.

Methods
Using the Changzhou Acute Myocardial Infarction Registry database, we retrospectively included AMI patients from January 2017 to August 2021 and analyzed the risk of AKI and all-cause mortality after PCI therapy. The patients were divided into two groups according to the use of DAPA (DAPA group and Ctrl group). Patients in the DAPA group started to use DAPA after admission and continued its use during hospitalization and follow-up period. Baseline characteristics were balanced between the two groups with a propensity score matching (PSM) analysis. The outcome was AKI within 7 days after PCI and all-cause mortality during a follow-up of 2 years. Univariate and multivariate logistic regression analyses were used to assess the association between DAPA and AKI risk.

Results
A total of 1839 AMI patients undergoing PCI were enrolled. DAPA was used in 278 (15.1%) patients. Postoperative AKI occurred in 351 (19.1%) cases. A 1:1 PSM analysis was used to reduce confounding factors. The multivariate stepwise regression analysis showed that DAPA (odds ratio, OR 0.66; 95% confidence interval, CI 0.44–0.97; P = 0.036) was an independent protective factor in the entire cohort. After matching, the use of DAPA in AMI patients was independently associated with a decline of AKI risk (OR 0.32; 95% CI, 0.19–0.53; P < 0.001) after hospital admission. Meanwhile, there were significant differences in mortality between the DAPA group and Ctrl group (2.5% vs. 7.6%, P = 0.012).

Conclusion
SGLT2 inhibitor DAPA was associated with lower risks of incident AKI and all-cause mortality in AMI patients after PCI therapy.
Antibacterial and antifungal activities of natural deep eutectic solvents
Authors: Bedair Hadeer M. , Samir Tamer M. , Mansour Fotouh R. 
Published: February 2024

Abstract
The increasing antibiotic resistance towards a panel of microorganisms is one of the public health concerns. For this reason, the search for alternatives to the widely used antibiotic has been undertaken. In the era of sustainable chemistry, deep eutectic solvents (DESs) have emerged as promising antimicrobial agents. These solvents possess several advantages such as low volatility, low flammability, ease of preparation, and typically low cost of production. These properties make DES suitable for various applications, including extraction of biomolecules and preparation of cosmetics. Natural DESs (NADESs) are special category of DESs prepared from natural sources, which matched the recent trends of leaning back to nature, and decreasing dependence on synthetic precursors. NADES can be prepared by heating and stirring, freeze-drying, evaporation, grinding, and ultrasound-assisted and microwave-assisted synthesis. Utilizing NADESs as an alternative to traditional antibiotics, which become ineffective over time due to bacterial resistance, holds great promise for these reasons. This review aims to discuss the antimicrobial properties of multiple NADESs, including antibacterial and antifungal activities. To the best of our knowledge, this review is the first literature survey of the antimicrobial activities of NADESs.

Key points
• Natural deep eutectic solvents are promising antimicrobial alternative to antibiotics
• NADES holds high potential for their activity against bacterial resistance
• NADES have also substantial antifungal activities
Lattice Path Bicircular Matroids
Authors: Guzmán-Pro Santiago , Hochstättler Winfried 
Published: February 2024

AbstractLattice path matroids and bicircular matroids are two well-known classes of transversal matroids. In the seminal work of Bonin and de Mier about structural properties of lattice path matroids, the authors claimed that lattice path matroids significantly differ from bicircular matroids. Recently, it was proved that all cosimple lattice path matroids have positive double circuits, while it was shown that there is a large class of cosimple bicircular matroids with no positive double circuits. These observations support Bonin and de Miers’ claim. Finally, Sivaraman and Slilaty suggested studying the intersection of lattice path matroids and bicircular matroids as a possibly interesting research topic. In this work, we exhibit the excluded bicircular matroids for the class of lattice path matroids, and we propose a characterization of the graph family whose bicircular matroids are lattice path matroids. As an application of this characterization, we propose a geometric description of 2-connected lattice path bicircular matroids.