bluuebunny/crossref_metadata_2025_split huggingface dataset:
A LDA-Based Social Media Data Mining Framework for Plastic Circular Economy
Authors: Xue Yangyimin , Kambhampati Chandrasekhar , Cheng Yongqiang , Mishra Nishikant , Wulandhari Nur , Deutz Pauline 
Published: January 2024

AbstractThe mass production of plastic waste has caused an urgent worldwide public health crisis. Although government policies and industrial innovation are the driving forces to meet this challenge, trying to understand public attitudes may improve the efficiency of this process. Social media has become the main ways for the public to obtain information and express opinions and feelings. This motivated us to mine the perceptions and behavioral responses towards plastic usage using social media data. In this paper, we proposed a framework for data collection and analysis based on mainstream media in the UK to obtain public opinions on plastics. An unsupervised machine learning model based on Latent Dirichlet Allocation (LDA) has been employed to analyse and cluster the topics to deal with the lack of annotation of the data contents. An additional dictionary method was then proposed to evaluate the sentiment of the comments. The framework also provides tools to visualise the model and results to stimulate insightful understandings. We validated the framework's effectiveness by applying it to analyse three mainstream social media, where 6 first-level topic categories and 13 second-level topic categories from the comment texts related to plastics have been identified. The results show that public sentiment towards plastic products is generally stable. The spatiotemporal distribution of each topic's sentiment is highly correlated with the number of occurrences.
Investigating the past, present and future responses of Shallap and Zongo Glaciers, Tropical Andes, to the El Niño Southern Oscillation
Authors: Richardson Alasdair , Carr Rachel , Cook Simon 
Published: January 2024

Abstract
Tropical Andean glaciers are highly sensitive to climate change and are impacted by the El Niño Southern Oscillation (ENSO). However, glaciological data are scarce, meaning that there are substantial knowledge gaps in the response of Andean glaciers to future anthropogenic and ENSO forcing and these are crucial to address, as glaciers represent a key water source for downstream populations and ecosystems. Here we integrated data from glaciological field studies, remote sensing, statistical analysis and glacier modelling to analyse the response of two Andean glaciers (Zongo and Shallap) to ENSO and their potential sensitivity to a range of climate forcing scenarios. Both glaciers retreated and experienced increasingly negative mass balance between the 1990s and the 2010s and responded strongly and rapidly to contemporary ENSO forcing, although this relationship evolved over time. Sensitivity experiments demonstrate that Shallap and Zongo are highly sensitive to ENSO forcing scenarios and the combination of ENSO and climate warming can cause rapid ice loss under the most extreme scenarios. Results also demonstrate the strong sensitivity of both glaciers to changes in the equilibrium line altitude, whereby rapid ice loss occurred when melt extended into present-day accumulation areas.
Licit or Illicit? Encroachments on ‘the Lord’s Waste’ in North-east Scotland, c.1400 – c.1800
Authors: Shepherd Colin 
Published: January 2024

AbstractThis paper seeks to show that encroachments in the North-east resulted from a range of social and economic drivers. Encroachments were enacted by members of a wide social spectrum, resulting in both top-down and bottom-up manifestations of engrossment of holdings. In this respect, it may be argued, North-east encroachments have a distinctive nature compared to English enclosures. The factors effecting encroachment can be seen to relate to topographic opportunism, demographic fluctuation, and a socio-agricultural environment that was already well-attuned to utilising dynamic settlement fluctuations for social and economic benefits. Only after the enactment of the 1695 Division of the Commonties Act did the socially diverse nature of such encroachment become increasingly monopolised by the landed gentry and began to reflect more closely English enclosure.
Solving heterogeneous-belief asset pricing models with short-selling constraints and many agents
Authors: Hatcher Michael 
Published: January 2024

AbstractShort-selling constraints are common in financial markets, while physical assets such as housing often lack markets for short-selling altogether. As a result, investment decisions are often restricted by such constraints. This paper studies asset prices in behavioral heterogeneous-belief models with short-selling constraints and arbitrarily many belief types. We provide conditions on beliefs such that short-selling constraints bind for different types, along with analytic expressions for price and demands that allow us to construct fast solution algorithms relevant for a wide range of models. An application studies how an alternative uptick rule, as in the United States, affects price dynamics and wealth distribution in a market with many belief types in evolutionary competition. In a numerical example, we highlight a scenario in which a modified version of the alternative uptick rule, triggered by smaller percentage falls in price, reduces both asset mispricing and wealth inequality relative to the current regulation. As extensions, we show how our method applies to multiple asset markets with short-selling constraints, additional heterogeneities, and price setting by a market maker.
Cross-language semantic-affective interaction – with evidence from Chinese EFL learners
Authors: Ye Xuanchen , Zhao Cuilian 
Published: January 2024

Abstract
Semantic and affective priming have long been treated separately in psycholinguistic studies. Recently, however, the question of whether and how these two primings interact has become controversial, especially in cross-language contexts where such discussions are rare. In the present study, four mixed-design experiments were conducted with Chinese EFL learners to investigate cross-language semantic-affective interactions: 3 (prime valence: negative, positive, neutral) × 2 (semantic relatedness: related, unrelated). Results show that semantic priming effects occurred in the L1L1 and L1L2 conditions, whereas affective priming effects were observed in the L2L2 condition. In the L2L1 priming condition, only emotion primes induced cross-language priming. These results suggest that semantic and emotional accesses are activated automatically and separately, but can facilitate cross-language word processing mutually. The results support the hierarchical representation of semantic features of emotion words from L1 to L2 in the unbalanced bilingual mental lexicon, while affective attributes are spread across a distributed network.
Global Impact of Sea Level Rise on Coastal Fresh Groundwater Resources
Authors: Zamrsky Daniel , Oude Essink Gualbert H. P. , Bierkens Marc F. P. 
Published: January 2024

AbstractGroundwater is the main freshwater source in many densely populated and industrialized coastal areas around the world. Growing future freshwater demand is likely to increase the water stress in these coastal areas, possibly leading to groundwater overexploitation and salinization. This situation will likely be aggravated by climate change and the associated projected sea level rise. Here, we assess the impact of sea level rise exclusively on coastal fresh groundwater resources worldwide (limited to areas with unconsolidated sedimentary systems) by estimating future decline in inland fresh groundwater volumes under three sea level rise scenarios following Representative Concentration Pathway (RCP) 2.6, 4.5, and 8.5. For that, 2D groundwater models in 1,200 coastal regions estimate the past, present and future groundwater salinity. Our results show that roughly 60 (range 16–96) million people living within 10 km from current coastline could lose more than 5% of their fresh groundwater resources by 2100 according to RCP 8.5 scenario compared to only 8 (range 0–50) million people based on RCP 2.6 scenario. We conclude that sea level rise will have severe consequences for many coastal populations heavily dependent on fresh groundwater.
Spacecraft Outgassing Observed by the BepiColombo Ion Spectrometers
Authors: Fränz M. , Rojo M. , Cornet T. , Hadid L. Z. , Saito Y. , André N. , Varsani A. , Schmid D. , Krüger H. , Krupp N. , Delcourt D. , Katra B. , Harada Y. , Yokota S. , Verdeil C. , Aizawa S. , Millilo A. , Orsini S. , Mangano V. , Fiethe B. , Benkhoff J. , Murakami G. 
Published: January 2024

AbstractDuring the first flyby of the BepiColombo composite spacecraft at Mercury in October 2021 ion spectrometers observed two intense spectral lines with energies between 10 and 70 eV. The spectral lines persisted also at larger distances from Mercury and were observed again at lower intensity during cruise phase in March 2022 and at the second and third Mercury flyby as a single band. The ion composition indicates that water is the dominant gas source. The outgassing causes the composite spacecraft to charge up to a negative potential of up to −50 V. The distribution and intensity of the lower energy signal depends on the intensity of low energy electron fluxes around the spacecraft which again depend on the magnetic field orientation. We interpret the observation as being caused by water outgassing from different source locations on the spacecraft being ionized in two different regions of the surrounding potential. The interpretation is confirmed by two dimensional particle‐in‐cell simulations.
Lithosphere Removal in the Sierra Nevada de Santa Marta, Colombia
Authors: Quiroga D. E. , Currie C. A. , Pearse J. 
Published: January 2024

AbstractThe Sierra Nevada de Santa Marta (SNSM) in northwestern Colombia is one of the world's highest coastal mountains, with an elevation above 5 km. Gravity measurements show that the SNSM has a positive Bouguer anomaly (>+130 mGal), indicating that the mountain lacks a crustal root. In this work, we test the hypothesis that these observations can be explained by gravitational removal of the dense lower lithosphere. We use 2D numerical models to examine the dynamics of lithosphere removal and its effect on surface elevation and gravity anomaly. The models consist of continental lithosphere that includes a pre‐thickened crustal region, representing the SNSM. In our preferred model, the dense mantle lithosphere and crustal root are gravitationally unstable and undergo removal as local drips within ∼10 Ma from the onset of foundering. This creates an area of thinned crust (∼38 km) underlain by a buoyant sublithospheric mantle where melting and low seismic velocities are predicted. Subsequent non‐isostatic forces maintain a topography of 3.3 km with a 2D Bouguer gravity anomaly of +103 mGal. Parameter tests show that a strong lower‐crustal rheology provides greater support for the high topography and that a weak mantle lithosphere rheology produces faster removal. The models demonstrate that local lithosphere dynamics can explain the first‐order observations in the SNSM. We propose that lithosphere removal could have occurred recently (∼2 Ma), explaining the localized low seismic velocity zone below the SNSM, or at 56–40 Ma, inducing anomalous short‐lived Eocene magmatism.
The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer
Authors: Kang Ye-Lim , Kim Jiyoung , Kwak Su-Bin , Kim Yi-Sook , Huh June , Park Jong-Wan 
Published: January 2024

AbstractDiabetes might be associated with increased cancer risk, with several studies reporting hyperglycemia as a primary oncogenic stimulant. Since glucose metabolism is linked to numerous metabolic pathways, it is difficult to specify the mechanisms underlying hyperglycemia-induced cancer progression. Here, we focused on the polyol pathway, which is dramatically activated under hyperglycemia and causes diabetic complications. We investigated whether polyol pathway-derived fructose facilitates hyperglycemia-induced gastric cancer metastasis. We performed bioinformatics analysis of gastric cancer datasets and immunohistochemical analyses of gastric cancer specimens, followed by transcriptomic and proteomic analyses to evaluate phenotypic changes in gastric cancer cells. Consequently, we found a clinical association between the polyol pathway and gastric cancer progression. In gastric cancer cell lines, hyperglycemia enhanced cell migration and invasion, cytoskeletal rearrangement, and epithelial-mesenchymal transition (EMT). The hyperglycemia-induced acquisition of metastatic potential was mediated by increased fructose derived from the polyol pathway, which stimulated the nuclear ketohexokinase-A (KHK-A) signaling pathway, thereby inducing EMT by repressing the CDH1 gene. In two different xenograft models of cancer metastasis, gastric cancers overexpressing AKR1B1 were found to be highly metastatic in diabetic mice, but these effects of AKR1B1 were attenuated by KHK-A knockdown. In conclusion, hyperglycemia induces fructose formation through the polyol pathway, which in turn stimulates the KHK-A signaling pathway, driving gastric cancer metastasis by inducing EMT. Thus, the polyol and KHK-A signaling pathways could be potential therapeutic targets to decrease the metastatic risk in gastric cancer patients with diabetes.
Pharmacokinetic-pharmacodynamic analysis of drug liking blockade by buprenorphine subcutaneous depot (CAM2038) in participants with opioid use disorder
Authors: Walsh Sharon L. , Comer Sandra D. , Zdovc Jurij Aguiar , Sarr Céline , Björnsson Marcus , Strandgården Kerstin , Hjelmström Peter , Tiberg Fredrik 
Published: January 2024

AbstractBuprenorphine is used to treat opioid use disorder (OUD). Weekly and monthly subcutaneous long-acting buprenorphine injections (CAM2038) provide more stable buprenorphine plasma levels and reduce the treatment burden, misuse, and diversion associated with sublingual transmucosal buprenorphine formulations. To characterize the pharmacokinetic/pharmacodynamic (PK/PD) relationship, a maximum inhibition (Imax) model was developed relating CAM2038 buprenorphine plasma concentration to drug liking maximum effect (Emax) visual analog scale (VAS; bipolar) score after intramuscular hydromorphone administration. Data included time-matched observations of buprenorphine plasma concentration and drug liking Emax VAS score after hydromorphone 18 mg administration in 47 non-treatment-seeking adults with moderate to severe OUD in a phase 2 study. Analysis used non-‍linear mixed-effects modeling (NONMEM®). The final Imax model adequately described the PK/PD relationship between buprenorphine plasma concentration and drug liking Emax VAS score. Simulations showed drug liking was effectively blocked at low buprenorphine plasma concentrations (0.4 ng/mL) where the upper 95% confidence interval of the drug liking Emax VAS score was below the pre-defined 11-point complete blockade threshold. The buprenorphine plasma concentration required to achieve 90% of the maximal effect (IC90) of drug liking was 0.675 ng/mL. Interindividual variability in responses to buprenorphine was observed; some participants experienced fluctuating responses, and a few did not achieve drug liking blockade even with higher buprenorphine plasma concentrations. This affirms the need to individualize treatment and titrate doses for optimal treatment outcomes. PK/PD models were also developed for desire to use VAS and Clinical Opiate Withdrawal Scale (COWS) scores, with results aligned to those for drug liking.
Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents
Authors: Giurini Eileena F. , Godla Aishvarya , Gupta Kajal H. 
Published: January 2024

AbstractCancer treatment remains a significant challenge due to issues such as acquired resistance to conventional therapies and the occurrence of adverse treatment-related toxicities. In recent years, researchers have turned their attention to the microbial world in search of novel and effective drugs to combat this devastating disease. Microbial derived secondary metabolites have proven to be a valuable source of biologically active compounds, which exhibit diverse functions and have demonstrated potential as treatments for various human diseases. The exploration of these compounds has provided valuable insights into their mechanisms of action against cancer cells. In-depth studies have been conducted on clinically established microbial metabolites, unraveling their anticancer properties, and shedding light on their therapeutic potential. This review aims to comprehensively examine the anticancer mechanisms of these established microbial metabolites. Additionally, it highlights the emerging therapies derived from these metabolites, offering a glimpse into the immense potential they hold for anticancer drug discovery. Furthermore, this review delves into approved treatments and major drug candidates currently undergoing clinical trials, focusing on specific molecular targets. It also addresses the challenges and issues encountered in the field of anticancer drug research and development. It also presents a comprehensive exposition of the contemporary panorama concerning microbial metabolites serving as a reservoir for anticancer agents, thereby illuminating their auspicious prospects and the prospect of forthcoming strides in the domain of cancer therapeutics.
Confirmation and expansion of the phenotype of the TCEAL1-related neurodevelopmental disorder
Authors: Albuainain Fatimah , Shi Yuwei , Lor-Zade Sarah , Hüffmeier Ulrike , Pauly Melissa , Reis André , Faivre Laurence , Maraval Julien , Bruel Ange-Line , Them Frédéric Tran Mau , Haack Tobias B. , Grasshoff Ute , Horber Veronka , Schot Rachel , van Slegtenhorst Marjon , Wilke Martina , Barakat Tahsin Stefan 
Published: January 2024

AbstractNumerous contiguous gene deletion syndromes causing neurodevelopmental disorders have previously been defined using cytogenetics for which only in the current genomic era the disease-causing genes have become elucidated. One such example is deletion at Xq22.2, previously associated with a neurodevelopmental disorder which has more recently been found to be caused by de novo loss-of-function variants in TCEAL1. So far, a single study reported six unrelated individuals with this monogenetic disorder, presenting with syndromic features including developmental delay especially affecting expressive speech, intellectual disability, autistic-like behaviors, hypotonia, gait abnormalities and mild facial dysmorphism, in addition to ocular, gastrointestinal, and immunologic abnormalities. Here we report on four previously undescribed individuals, including two adults, with de novo truncating variants in TCEAL1, identified through trio exome or genome sequencing, further delineating the phenotype of the TCEAL1-related disorder. Whereas overall we identify similar features compared to the original report, we also highlight features in our adult individuals including hyperphagia, obesity, and endocrine abnormalities including hyperinsulinemia, hyperandrogenemia, and polycystic ovarian syndrome. X chromosome inactivation and RNA-seq studies further provide functional insights in the molecular mechanisms. Together this report expands the phenotypic and molecular spectrum of the TCEAL1-related disorder which will be useful for counseling of newly identified individuals and their families.
Systemic exposure to aflibercept after intravitreal injection in premature neonates with retinopathy of prematurity: results from the FIREFLEYE randomized phase 3 study
Authors: Stahl Andreas , Azuma Noriyuki , Wu Wei-Chi , Lepore Domenico , Sukgen Emine , Nakanishi Hidehiko , Mazela Jan , Leal Sergio , Pieper Alexander , Schlief Sarah , Eissing Thomas , Turner Kenneth C. , Zhao An , Winkler Julia , Höchel Joachim , Köfüncü Evra , Zimmermann Torsten ,   on behalf of the FIREFLEYE Study Group
Published: January 2024

Abstract
Background
There are no data on pharmacokinetics, pharmacodynamics, and immunogenicity of intravitreal aflibercept in preterm infants with retinopathy of prematurity (ROP). FIREFLEYE compared aflibercept 0.4 mg/eye and laser photocoagulation in infants with acute-phase ROP requiring treatment.

Methods
Infants (gestational age ≤32 weeks or birthweight ≤1500 g) with treatment-requiring ROP in ≥1 eye were randomized 2:1 to receive aflibercept 0.4 mg or laser photocoagulation at baseline in this 24-week, randomized, open-label, noninferiority, phase 3 study. Endpoints include concentrations of free and adjusted bound aflibercept in plasma, pharmacokinetic/pharmacodynamic exploration of systemic anti-vascular endothelial growth factor effects, and immunogenicity.

Results
Of 113 treated infants, 75 received aflibercept 0.4 mg per eye at baseline (mean chronological age: 10.4 weeks), mostly bilaterally (71 infants), and with 1 injection/eye (120/146 eyes). Concentrations of free aflibercept were highly variable, with maximum concentration at day 1, declining thereafter. Plasma concentrations of adjusted bound (pharmacologically inactive) aflibercept increased from day 1 to week 4, decreasing up to week 24. Six infants experienced treatment-emergent serious adverse events within 30 days of treatment; aflibercept concentrations were within the range observed in other infants. There was no pattern between free and adjusted bound aflibercept concentrations and blood pressure changes up to week 4. A low-titer (1:30), non-neutralizing, treatment-emergent anti-drug antibody response was reported in 1 infant, though was not clinically relevant.

Conclusions
24-week data suggest intravitreal aflibercept for treatment of acute-phase ROP is not associated with clinically relevant effects on blood pressure, further systemic adverse events, or immunogenicity.

ClinicalTrials.gov Identifier
NCT04004208.
Silica-associated proteins from hexactinellid sponges support an alternative evolutionary scenario for biomineralization in Porifera
Authors: Shimizu Katsuhiko , Nishi Michika , Sakate Yuto , Kawanami Haruka , Bito Tomohiro , Arima Jiro , Leria Laia , Maldonado Manuel 
Published: January 2024

AbstractMetazoans use silicon traces but rarely develop extensive silica skeletons, except for the early-diverging lineage of sponges. The mechanisms underlying metazoan silicification remain incompletely understood, despite significant biotechnological and evolutionary implications. Here, the characterization of two proteins identified from hexactinellid sponge silica, hexaxilin and perisilin, supports that the three classes of siliceous sponges (Hexactinellida, Demospongiae, and Homoscleromorpha) use independent protein machineries to build their skeletons, which become non-homologous structures. Hexaxilin forms the axial filament to intracellularly pattern the main symmetry of the skeletal parts, while perisilin appears to operate in their thickening, guiding extracellular deposition of peripheral silica, as does glassin, a previously characterized hexactinellid silicifying protein. Distant hexaxilin homologs occur in some bilaterians with siliceous parts, suggesting putative conserved silicifying activity along metazoan evolution. The findings also support that ancestral Porifera were non-skeletonized, acquiring silica skeletons only after diverging into major classes, what reconciles molecular-clock dating and the fossil record.