bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coding splits in the adnominal possessive construction and alienability: the case of Mandinka (West Mande)
Authors: Creissels Denis 
Published: October 2023

Abstract
In the adnominal possessive construction of Mandinka (a West Mande language spoken in Gambia, Senegal, and Guinea Bissau), the possessor NP may be simply juxtaposed to the possessee or flagged by the postposition lá. This coding split shows unusual properties in comparison with most of the languages having formally similar coding splits. Crucially, any noun can be modified by an unflagged possessor, depending on the semantic nature of the possessor and of its relation to the possessee. The present-day distribution of the two constructions cannot be analyzed as reflecting an alienability contrast, nor can the alienability contrast account for the emergence of this coding split. The data analyzed in this study suggest that the lá-construction initially referred to situations where the possessor determines the location of the possessee, but is grammaticalized differently depending on the grammatical nature of the head noun and the semantic nature of the modifier. The Mandinka data also show the limits of explanations in terms of discourse frequency, and the need to admit that semantic features such as animacy and control may play a crucial role in the genesis of coding splits in the adnominal possession construction.
Correlation of Magnesium Level with Cardiac and Hepatic Hemosiderosis Measured by T2*MRI Technique and Age in Patients with Thalassemia Major
Authors: Ghasemi Ali , Ghaffari Kazem , Hoseini Fatemeh , Eghbali Aziz , Sajadei Nooshin , Falahati Vahid , Ghandi Yazdan 
Published: October 2023

Background: Given the association of hypomagnesemia with cardiac arrhythmia, the aim of this study was to investigate the relationship between serum magnesium levels with age and T2* magnetic resonance imaging (MRI) findings of the heart and liver in patients with thalassemia major (TM).
Materials and Methods: In a descriptive cross-sectional study, a total of 62 patients with β-thalassemia major aged 11-48 years were selected at the Amir-Kabir Hospital, Arak, Iran. Serum magnesium, ferritin, and iron levels of patients were measured, and the rate of cardiac and hepatic hemosiderosis of patients was extracted according to the routine T2*MRI method.
Results: The mean age of the patients at diagnosis was 32.6 years. The comparison of TM patients with and without hepatic/cardiac hemosiderosis demonstrated that mean levels of serum ferritin, serum iron, and age were significantly higher in TM patients with cardiac hemosiderosis than in hepatic/cardiac non-hemosiderosis (P < 0.05); however, there was no significant difference in mean levels of serum magnesium in TM patients with and without hepatic/cardiac hemosiderosis (P = 0.279). Interestingly, the correlation of age with serum magnesium levels in TM patients revealed a statistically significant and moderate inverse correlation (r = -0.56, P = 0.013).
Conclusion: Hypomagnesemia may occur in a time-dependent manner. It is recommended that, in addition to cardiac and hepatic T2*MRI, serum magnesium levels be measured by using magnesium replacement if necessary.
No Association of AS3MT Gene Polymorphisms with Susceptibility to Hepatotoxicity and in APL Patients Treated with AS2O3: A Single Center Study
Authors: Joneidi Zeinab , Mortazavi Yousef , Chahardouli Bahram , Rostami Shahrbano , Vaezi Mohammad , Nabipour Majid , Biglari Alireza , Ghavamzadeh Ardeshir 
Published: October 2023

Background: Arsenic three oxide (As2O3) is the treatment choice for acute promyelocytic leukemia (APL). Little is known about possible risk factors with predictive value for toxicity caused by As2O3. Biomethylation is considered to be a major pathway of detoxification for inorganic arsenics (iAs). Arsenic Methyltransferase (AS3MT) is one of the key enzymes involved in the transfer of a methyl group from S-adenosyl-L-methionine to trivalent arsenical and plays a critical role in arsenic detoxification. Polymorphisms in hAS3MT lead to a change in the catalytic activity of the enzyme and may increase the risk of arsenic-related toxicity. In this study, we investigated the association of the AS3MT polymorphisms (rs11191439, rs3740390, and rs3740393) genes with hepatotoxicity in APL patients treated with As2O3.
Materials and Methods: Genotyping was performed in 140 adult patients with APL treated with As2O3 using PCR-RFLP for rs11191439 and tetra-primer ARMS-PCR for rs3740390 and rs3740393. The results of PCR-RFLP and ARMS-PCR were confirmed by direct sequencing of 10 % of DNA samples. The results were analyzed using SNPStats, SPSS, and FinchTV. Hepatotoxicity was graded according to the National Cancer Institute's Common Toxicity Criteria (CTC).
Results: Hepatotoxicity was seen in 52 of the 140 patients (37.1%), with grades I and II hepatotoxicity in 40 (28.6%) and grades III and IV hepatotoxicity in 12 (8.5%) patients. The association between the three polymorphisms and hepatotoxicity was evaluated using five genetic models and none of the three studied polymorphisms were significantly associated with hepatotoxicity.
Discussion: The results of our study showed that AS3MT rs11191439, rs3740390, and rs3740393 polymorphisms are not associated with hepatotoxicity in APL patients. Genetic polymorphisms in enzymes which are involved in arsenic metabolism have been shown to have ethnicity and race-related differences. To more precisely characterize the association between AS3MT gene polymorphism and hepatotoxicity, future large-scale studies in non-Asian populations and other ethnicities are needed.
As materialidades como um fundamento para o trabalho docente na Educação Infantil
Authors: Pereira Evangelista Lidiane , Vieira da Rosa Alves Camila , Dias Julice 
Published: October 2023

Este artigo tem por objetivo apresentar reflexões a respeito da análise da relação curricular entre os elementos estruturais da docência com bebês e as materialidades presentes no planejamento das professoras da Rede Municipal de Ensino de Florianópolis, tomando como base uma pesquisa em nível de Mestrado nos Núcleos Municipais de Educação Infantil. Toma-se como fontes os documentos oficiais e legais que orientam o cuidado e a educação de bebês, crianças bem pequenas e crianças pequenas. E como sustentação teórica ancora-se na produção que se debruça sobre a especificidade da docência com os bebês, a organização dos espaços, ambientes e materialidades na e para a Educação Infantil. O estudo afirma a importância e o sentido curricular das materialidades dispostas aos bebês na organização do trabalho pedagógico.
Palavras-chave: crianças, espaços, docência.

Materialities as a foundation for teaching work in Early Childhood Education
ABSTRACT. This article aims to present reflections about the analysis of the curricular relationship between the structural elements of teaching with babies and the materialities present in the planning of teachers of the Municipal Education Network of Florianópolis, based on a research at the Master's level in the Municipal Centers of Early Childhood Education. The sources are the official and legal documents that guide the care and education of babies, very young children and young children. And as a theoretical support, it is anchored in the production that focuses on the specificity of teaching with babies, the organization of spaces, environments and materialities in and for Early Childhood Education. The study affirms the importance and curricular meaning of the materialities arranged to babies in the organization of pedagogical work.
Keywords: children, spaces, teaching.

Las materialidades como base para el trabajo docente en Educación Infantil
RESUMEN. Este artículo tiene como objetivo presentar reflexiones sobre el análisis de la relación curricular entre los elementos estructurales de la enseñanza con bebés y las materialidades presentes en la planificación de los maestros de la Red Municipal de Educación de Florianópolis, a partir de una investigación a nivel de maestría en los Centros Municipales de Educación Infantil. Las fuentes son los documentos oficiales y legales que guían el cuidado y la educación de los bebés, los niños muy pequeños y los niños pequeños. Y como soporte teórico, se ancla en la producción que se centra en la especificidad de la enseñanza con bebés, la organización de espacios, entornos y materialidades en y para la Educación Infantil. El estudio afirma la importancia y el significado curricular de las materialidades dispuestas a los bebés en la organización del trabajo pedagógico.
Palabras clave: niños, espacios, enseñanza.
Gestão democrática: experiências de práticas de gestores em escolas de educação básica
Authors: Bonez Juliane , Paulo dos santos Almir , Prsybyciem Moises Marques 
Published: October 2023

O artigo tem o objetivo de analisar as experiências de práticas de gestão democrática em escolas de educação básica, desenvolvidas por gestores escolares. A abordagem metodológica utilizada na pesquisa foi a qualitativa, em relação ao objeto de estudo, sendo classificada como pesquisa de campo. Evidenciou-se a importância do papel da gestão escolar como mediadora. A participação do todo gera autonomia em cada sujeito, propiciando a tomada de decisão de forma coletiva. Esses resultados contribuem para estimular a democratização da educação para e pela democracia por meio de uma gestão democrática, bem como para repensar a formação de gestores escolares.
Palavras-chave: gestão democrática, democracia, experiências, comunidade escolar, gestão escolar.

Democratic management: experiences of management practices in basic education schools
ABSTRACT. The article aims to analyze the experiences of democratic management practices in basic education schools, developed by school managers. The methodological approach used in the research was qualitative and in relation to the object of study it was classified as field research. The importance of the role of school management as a mediator was highlighted. The participation of the whole generates autonomy in each subject, providing collective decision-making. These results contribute to encourage the democratization of education for and through democracy through democratic management, as well as to rethink the training of school managers.
Keywords: democratic management, democracy, experiences, school community, school management.

Gestión democrática: experiencias de prácticas gerenciales en escuelas de educación básica
RESUMEN El artículo tiene como objetivo analizar las experiencias de prácticas de gestión democrática en escuelas de educación básica, desarrolladas por gestores escolares. El enfoque metodológico utilizado en la investigación fue cualitativo y en relación al objeto de estudio se catalogó como investigación de campo. Se destacó la importancia del papel de la dirección escolar como mediador. La participación del conjunto genera autonomía en cada sujeto, facilitando la toma de decisiones colectiva. Estos resultados contribuyen a incentivar la democratización de la educación para y por la democracia a través de la gestión democrática, así como a repensar la formación de directivos escolares.
Palabras clave: gestión democrática, democracia, experiencias, comunidad escolar, gestión escolar.
Thermal Regime Evolution of Two-dam Coexistence: A Special Withdrawal Measure in Fengman Reservoir, China
Authors: Jia Yunxiao , Yang Xiaoqian , Jiang Hao , Lu Bo , Tuo Youcai , Deng Yun , Zhang Xu , Li Jia 
Published: October 2023

Abstract
The two-dam coexistence (TDC) is a special measure adopted by the Chinese Fengman Dam for risk management of old and dangerous dams, which acts as selective withdrawal by demolishing a partial elevation of the original dam. This study combined measured water temperature data for many years with the characteristics of the TDC to reveal the influence of the TDC on the thermal stratification in front of the dam and the withdrawal water temperature (WWT) process. The results showed that the TDC accompanying the operation and outflow daily regulation of the two power stations caused a general decline and periodic fluctuation in temperature contours. The metalimnion moved upward, and stratification strengthened with the temperature gradient from 0 to 10.5 °C/m. The vertical mixture was weakened with the difference between the surface and bottom water temperatures ranging from 6.8 °C to 26.8 °C. The stratification stability of the water column was 1.8 times that with the one-dam condition (ODC), and there were interannual differences. The buoyancy frequency decreased correspondingly. Additionally, the TDC had a higher WWT in the warming period (4.3 °C on average from May to Jun.) and a lower WWT in the freeze-up period (0.1 °C on average from Jan. to Feb.) than the ODC. The maximum temperature difference between the front of the two dams occurred at the bottom of the reservoir (3.5 °C to 12.0 °C), verifying that the main WWT difference was caused by releasing water above the demolition elevation. With the TDC, the withdrawal layer raised 20.0 m from near the intake to near the demolition elevation. Thus, more stable stratification and various changes in the WWT played a vital role in several sensitive elements and reservoir management. This study can provide practical experience for the effect of similar disease reservoirs treatment and can provide a reference for optimizing water quality management strategies.
Deciphering Population Immune Dynamics of SARS-CoV-2
Authors: Nilles Eric , Roberts Kathryn , Aubin Michael de St. , Mayfield Helen , Restrepo Angela Cadavid , Dumas Devan , Garnier Salome , Etienne Marie , Duke William , Jarolim Petr , Oasan Timothy , Peña Farah , Abdalla Gabriela , Lopez Beatriz , Cruz Lucia de la , Sanchez Isaac , Murray Kristy , Baldwin Margaret , Skewes-Ramm Ronald , Paulino Cecilia Then , Lau Colleen , Kucharski Adam 
Published: October 2023

Abstract

Individual immune responses to SARS-CoV-2 are well-studied, while the combined effect of these responses on population-level dynamics of immunity remain poorly understood. In this study we examined spike antibody responses among participants in the Dominican Republic, selected using a multistage household sampling technique and spanning waves of intense Delta, BA.1, BA.2, and BA.4/5 transmission (August 2021 to November 2022). We observed a transformation in population antibody markers from an irregular to a normalized Gaussian distribution. This change can be attributed to boosted antibody responses in individuals with initially lower immunity, and the waning of antibodies in those with higher baseline levels, irrespective of any subsequent vaccinations. Our findings suggest a process of “immunological leveling" at the population level, primarily driven by immune restricted transmission. Out-of-sample validation reliably predicted later S-antibody levels, affirming the consistency of baseline measurements as a predictor. The generalizability of these dynamics was reinforced by consistent findings across distinct regions in the Dominican Republic. Our results suggest that core principles of ecological competition can provide insights into the patterns of immune responses and susceptibility at a population level. These ecological principles can enhance our understanding of immunoepidemiology, help refine transmission models and potentially guide public health interventions for future emerging pathogens.
UV Reflectance of Spacecraft Materials and Analog Soils: Implications for Bioburden Reductions on the Undersides of Mars Rovers
Authors: Schuerger Andrew C. , Moores John E. 
Published: October 2023

Abstract

The Mars Sample Return mission architecture will utilize three spacecraft to collect, cache, recover, launch, and return to Earth a diversity of regolith and rock samples. However, no comprehensive Mars Microbial Survival (MMS) model currently exists. As an initial effort in building a MMS model, we examined the UV reflectance of 15 spacecraft materials and seven Mars analog soils within the context of the Perseverance mission. Data were used to predict the times required to achieve one lethal dose (syn., Sterility Assurance Level [SAL]; def. as a bioburden reduction of ‒12 logs). Results suggest that a single SAL dosage of UVC was achieved on exposed surfaces on the upper deck of Perseverance within a few hours to a few sols post-landing at Jezero Crater. The overall average for UVC reflectance from spacecraft materials was approx. 10%. The overall UVC reflectance from Mars analog soils was measured at 1.3%. The Adaptive Caching Assembly (ACA) on Perseverance is located on the forward edge of the underbelly of the spacecraft. Modeling of the accumulated UVC dosage for the ACA yielded a prediction of reaching one SAL for downward facing surfaces at 93 sols that receive ‘single bounce’ UVC photons from the local terrain. The SAL increases to 930 sols, if an additional ‘bounce’ of the solar UV irradiation is required to reach a partially protected site in the ACA hardware. The current study is the first to report on the UVC reflectance from a diversity of spacecraft materials.
Zero Knowledge and Oblivious Ads Recommendation
Authors: Rajagopalan Anirudh , Singh Kunwar , Jayashrri Balaji , John Anu E 
Published: October 2023

Abstract
Interest-based Advertising, sometimes called online behavioural advertising, uses data collected from online activity on a digital device (e.g. smart phone, tablet, computer, etc.) using cookies, pixel tags, and other technologies to show personalized ads. While interest-based advertising is invaluable in helping advertisers reach the most suitable audience for their products, user privacy could be better protected if it could be ac-complished without collecting a particular individual’s browsing history.
This paper aims to implement an amalgamation of cryp-tography techniques that leverage zero-knowledge proof
(ZKP) cryptography and oblivious transfer (OT) along-side standard hashing and fuzzy logic to ensure that users’ sensitive, personal and private data is always kept secure.
A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance
Authors: Maldonado Horacio , Dreger Marcel , Wolanska Katarzyna , Kyriakou Theano , Marotta Valeria , Webster Justine , Wang Jun , Rusilowicz-Jones Emma , Marshall John , Coulson Judy , Macpherson Iain , Hurlstone Adam , Morgan Mark 
Published: October 2023

Abstract
HER2 and αVβ6 integrin are independent predictors of breast cancer survival and metastasis. We investigated αVβ6 signalling and identified an αVβ6/HER2 crosstalk mechanism, which drives invasion and is dysregulated in drug resistant HER2+ breast cancer cells. Proteomic approaches revealed ligand-bound αVβ6 recruits HER2 and a trafficking regulatory subnetwork comprising the small GTPases RAB5 and RAB7A, and the Rab regulator GDI2. We show that the RAB5/RAB7A/GDI2 functional module mediates direct crosstalk between αVβ6 and HER2, impacting receptor trafficking and signalling. Acute exposure to trastuzumab increases recruitment of the RAB5/RAB7A/GDI2 subnetwork to αVβ6, but trastuzumab resistance decouples GDI2 recruitment from this trafficking module. Consequently, GDI2, RAB5 and RAB7A cooperate to regulate migration and TGFβ activation to promote tumour cell invasion and dissemination. However, these mechanisms are dysregulated following acquired trastuzumab resistance. In patients, RAB5, RAB7A & GDI2 expression correlates with patient survival and αVβ6 expression predicts therapeutic response following breast cancer relapse. Thus, the RAB5/RAB7A/GDI2 subnetwork regulates αVβ6-HER2 crosstalk to drive breast cancer invasion, but is subverted in trastuzumab resistant cells to drive αVβ6- and HER2-independent tumour progression.
A DECONSTRUCTIVE READING TO FIND HOW PATERNALISM WORKS IN TEXTS FOR CHILDREN
Authors: Surya Sagiro Batubara  , Burhan Nurgiyantoro  , Widyastuti Purbani  
Published: October 2023

This is a qualitative descriptive study with the aim to find out how paternalism works in 12 Indonesian folktales by applying Derrida’s deconstruction theory. Twelve folktales from children books that represents theme about moral ideology were chosen as the objects of this study. Data collection did by document analysis. Data analysis then conducted by doing Derrida’s deconstruction analysis as proposed by Barry that involves verbal, textual, and linguistic analysis with the aim to investigate how paternalism works and give significant meaning in the folktales. The results that the paternalism seems to explain about pure paternalisms since the ideology closely related to give explanations about father (men) who completely takes control over children and women (wife). Even though the controls seems to be considered as for good reasons, this study proves the the paternalism show limitation of freedom and also reflects autonomous violation over women and children. The paternalism explains about men domination in public and domestic institution that legalize men to have power over women and children in domestic affairs. The paternalism supports men domination in culture and social institution, that makes men have power in marital institution and make marital life as women’ purpose in life in the name of norm and value in society. The paternalism also explains boy preference in marital affairs that explained discrimination over children.