bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Endoplasmic Reticulum‐Targeted Metal–Organic Framework–Confined Ruthenium (Ru) Nanozyme Regulation of Oxidative Stress for Central Post‐Stroke Pain
Authors: Bai Qian , Han Yupeng , Khan Suliman , Wu Tingting , Yang Ying , Wang Yingying , Tang Hao , Li Qing , Jiang Wei 
Published: October 2023

AbstractCentral post‐stroke pain (CPSP) is a chronic neuropathic pain caused by cerebrovascular lesion or disfunction after stroke. Convincing evidence suggest that excessive reactive oxygen species (ROS), generated matrix metalloproteinase (MMPs) and neuroinflammation are largely involved in the development of pain. In this study, an effective strategy is reported for treating pain hypersensitivity using an endoplasmic reticulum (ER)‐targeted metal–organic framework (MOF)‐confined ruthenium (Ru) nanozyme. The Ru MOF is coated with a p‐dodecylbenzene sulfonamide (p‐DBSN) modified liposome with endoplasmic reticulum‐targeted function. The experimental results reveals that ROS, Emmprin, MMP‐2, and MMP‐9 are upregulated in the brain of CPSP mice, along with the elevated expression of inflammation markers such as TNF‐α and IL‐6. Compared to vehicle, one‐time intravenous administration of ER‐Ru MOF significantly reduces mechanical hypersensitivity after CPSP for three days. Overall, ER‐Ru MOF system can inhibit oxidative stress in the brain tissues of CPSP model, reduce MMPs expression, and suppress neuroinflammation response‐induced injury, resulting in satisfactory prevention and effective treatment of CPSP during a hemorrhagic stroke. The ER‐Ru MOF is expected to be useful for the treatment of neurological diseases associated with the vicious activation of ROS, based on the generality of the approach used in this study.
Revealing the Mutually Enhanced Mechanism of Necroptosis and Immunotherapy Induced by Defect Engineering and Piezoelectric Effect
Authors: Du Yaqian , Yang Jiani , He Fei , Zhao Xudong , Zhou Jialing , Zang Pengyu , Liu Changlin , Xie Ying , Zhang Yanqiao , Yang Piaoping 
Published: October 2023

AbstractOwing to low immunogenicity‐induced immune escape and short‐term circulating immune responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering immunogenic cell death and establishing a long‐term, mutually reinforced treatment modality are urgent challenges. In this study, ultrathin CaBi2Nb2O9 nanosheets with tunable oxygen vacancies (abbreviated as CBNO‐OV1) are prepared for synergistic necroptosis and immunotherapy. The optimized vacancy concentration significantly improves the piezoelectric effect under ultrasound irradiation, thereby considerably improving the generation of reactive oxygen species (ROS). Density functional theory shows that oxygen vacancies can improve the efficiency of electron hole separation by suppressing their recombination, thus resulting in enhanced piezocatalytic activity. Moreover, the piezoelectric effect improves the permeability of tumor cell membranes, thus resulting in Ca2+ influx. Additionally, CBNO‐OV1 also releases a portion of Ca2+, which induces necroptosis assisted by explosive ROS. Ribonucleic acid transcription tests suggest the mechanisms associated with immune response activation and necroptosis. More importantly, necroptosis can trigger a significant immune response in vivo, thus activating macrophage M1 polarization through the NF‐kappa B pathway and promoting T‐cell differentiation.Tumor Necrosis Factor‐α differentiated from macrophages conversely promotes necroptosis, thus realizing a mutually enhanced effect. This study demonstrates the feasibility of mutually reinforced necroptosis and immunotherapy for amplifying tumor efficacy.
Ultrahigh Capacity from Complexation‐Enabled Aluminum‐Ion Batteries with C70 as the Cathode
Authors: Huang Chenli , Yang Ying , Li Mengyang , Qi Xiaoqun , Pan Changwang , Guo Kun , Bao Lipiao , Lu Xing 
Published: October 2023

AbstractRestricted by the available energy storage modes, currently rechargeable aluminum‐ion batteries (RABs) can only provide a very limited experimental capacity, regardless of the very high gravimetric capacity of Al (2980 mAh g−1). Here, a novel complexation mechanism is reported for energy storage in RABs by utilizing 0D fullerene C70 as the cathode. This mechanism enables remarkable discharge voltage (≈1.65 V) and especially a record‐high reversible specific capacity (750 mAh g−1 at 200 mA g−1) of RABs. By means of in situ Raman monitoring, mass spectrometry, and density functional theory (DFT) calculations, it is found that this elevated capacity is attributed to the direct complexation of one C70 molecule with 23.5 (super)halogen moieties (superhalogen AlCl4 and/or halogen Cl) in average, forming (super)halogenated C70·(AlCl4)mCln‐m complexes. Upon discharging, decomplexation of C70·(AlCl4)mCln‐m releases AlCl4−/Cl− ions while preserving the intact fullerene cage. This work provides a new route to realize high‐capacity and long‐life batteries following the complexation mechanism.
Tethered Small‐Molecule Acceptor Refines Hierarchical Morphology in Ternary Polymer Solar Cells: Enhanced Stability and 19% Efficiency
Authors: Zhang Ming , Chang Bowen , Zhang Rui , Li Shangyu , Liu Xinpeng , Zeng Liang , Chen Qi , Wang Li , Yang Liangrong , Wang Haiqiao , Liu Jiangang , Gao Feng , Zhang Zhi‐Guo 
Published: October 2023

AbstractPolymer solar cells (PSCs) are promising for efficient solar energy conversion, but achieving high efficiency and device longevity within a bulk‐heterojunction (BHJ) structure remains a challenge. Traditional small‐molecule acceptors (SMAs) in the BHJ blend show thermodynamic instability affecting the morphology. In contrast, tethered SMAs exhibit higher glass transition temperatures, mitigating these concerns. Yet, they might not integrate well with polymer donors, causing pronounced phase separation and overpurification of mixed domains. Herein, a novel ternary device is introduced that uses DY‐P2EH, a tethered dimeric SMA with conjugated side‐chains as host acceptor, and BTP‐ec9, a monomeric SMA as secondary acceptor, which respectively possess hypomiscibility and hypermiscibility with the polymer donor PM6. This unique combination affords a parallel‐connected ternary BHJ blend, leading to a hierarchical and stable morphology. The ternary device achieves a remarkable fill factor of 80.61% and an impressive power conversion efficiency of 19.09%. Furthermore, the ternary device exhibits exceptional stability, retaining over 85% of its initial efficiency even after enduring 1100 h of thermal stress at 85 °C. These findings highlight the potential advantage of tethered SMAs in the design of ternary devices with a refined hierarchical structure for more efficient and durable solar energy conversion technologies.
Process Optimization for Syngas Production from the Dry Reforming of Methane over 5Ni+3Sr/10Zr+Al Catalyst Using Multiple Response Surface Methodology
Authors: Al‐Fatesh Ahmed S. , El‐Salamony Radwa A. , Roushdy Mai H. , Alwan Saba M. , Osman Ahmed I. , Alfatesh Sadeq A. , Ahmed Hamid , Fakeeha Anis H. , Ibrahim Ahmed A. 
Published: October 2023

Abstract5Ni+3Sr/10Zr+Al catalyst is synthesized using the impregnation method, characterized, and tested for dry reforming of methane. The influence of reaction temperature, feed ratio (CO2/CH4), and gas hour space velocity are examined using multiple response surface methodology through three factors in, a four‐level central composite design. Second and higher‐order regression models are applied to evaluate the interaction between the process parameters and responses. The results indicate that the reaction temperature is the most influential followed by the space velocity, while the feed ratio has a weak effect. The optimum values that maximize each of the response variables are found to be the reaction temperature at 746 °C, the space velocity of 12 000 ccg−1h−1, and the feed ratio of 0.958. Under these conditions, the predicted CH4 and CO2 conversions are 86.83% and 92.27%, respectively. While the H2/CO ratio is 1.02. On the other hand, the experimental results match the predicted ones when the optimum predicted operating conditions are used for the process. A weight loss of <16% is obtained on the spent catalyst after 86 h on stream. This is attributed to the highly basic and oxidative nature of the ZrO2 co‐supported catalyst and indicates the suitability of the developed catalyst.
Advances in Skeletal Muscle Engineering in Biomedical Research
Authors: Zhao Mengqian , Liu Haitao , Zhang Xu , Qin Jianhua 
Published: October 2023

AbstractSkeletal muscle contributes significantly to human health, which is closely relevant to human locomotion, energy metabolism, immune regulation, and aging. Skeletal muscle holds the potential to recover its healthy condition via self‐repairing after minor damage. However, the capacity of sarcous self‐repair becomes incompetent following massive trauma or some myopathy, which raises a huge demand for skeletal muscle regeneration. Skeletal muscle engineering aims to rebuild muscle tissues in vitro to repair muscle injuries, develop pathological models, advance myopathy‐related research, and explore myopathy‐related medications. This review summarizes the advances in skeletal muscle engineering, including the cell resources that can be used in muscle regeneration, the recent progress of rebuilding methods for skeletal muscle engineering, as well as the biomedical applications of engineered skeletal muscle for tissue repair, drug testing, disease modeling, and soft robots. Finally, the challenges and future perspectives are discussed on improving skeletal muscle engineering by integrating multidisciplinary approaches, thus accelerating the technological innovation and translational application of this area.
Photoinduced Polymorphism of Fluorescent Organic Molecules in Solid State
Authors: Zhu Guanqun , Liu Zhiyang , Bisoyi Hari Krishna , Qi Qi , Liu Xiaogang , Li Quan 
Published: October 2023

AbstractA new organic molecule is found to be able to form different fluorescent aggregation states in both single crystals and powders. When irradiated with ultraviolet light, single crystals and powders exhibit an in situ change in the fluorescence color from blue to green and then to chartreuse without changing the chemical groups. This stems from photoinduced changes in the molecular conformation and packing in the solid state. Two or three fluorescence colors can be displayed simultaneously in a single organic crystal by controlling the irradiation time. Under irradiation with intense ultraviolet light, deformations, movements and in situ welding of crystals can be achieved by utilizing the photothermal effect. This work demonstrates a new strategy for inducing different behaviors of organic solid state with stimulation by single‐wavelength light.
2D Heterostructures Induced Charge Transfer and Trapping for Hybrid Optically and Electrically Controllable Nonvolatile Memory
Authors: Li Sin‐En , Lu Guan‐Zhang , Shen Ji‐Lin , Wu Meng‐Jer , Chen Yu‐Ting , Mustaqeem Mujahid , Chen Yang‐Fang 
Published: October 2023

AbstractNonvolatile memory is an indispensable component of electronic devices. However, the current technology makes it difficult to satisfy the emerging big data demand. To circumvent the existing problems, herein, a first attempt is made to achieve multifunctional nonvolatile memory based on all 2D heterostructures, consisting of histidine‐doped molybdenum disulfide quantum disks mixed with graphene oxide and a graphene macroscopic heterojunction. The designed device possesses intriguing hybrid electrically and optically controllable nonvolatile memory functionalities. By harnessing the unique properties of these materials, memory devices demonstrate long‐term stability and nonvolatile characteristics under both optical and electrical control signals. These devices possess outstanding features, such as multiple read‐write cycles, multi levels, and fast switching speeds, overcoming the limitations of traditional components. To explore the underlying physical mechanism, the Fermi level of graphene is measured and it is confirmed that the charge transfer and trapping across the heterojunctions are the major factors responsible for the observed behavior. This study demonstrates that 2D heterostructures for hybrid optically and electrically controllable nonvolatile memory pave an alternative route for the next‐generation information technology.
Aza[7]helicene Functionalized Triphenylmethyl Radicals with Circularly Polarized Doublet Emission
Authors: Gross Markus , Zhang Fangyuan , Arnold Mona E. , Ravat Prince , Kuehne Alexander J. C. 
Published: October 2023

AbstractSynthesis and characterization of configurationally stable chiral aza[7]helicene‐functionalized trityl radicals are reported. To overcome the problem of incomplete radical formation after coupling the trityl radical to the chiral aza[7]helicenes in a nucleophilic aromatic substitution, this study instead employs Pd‐catalyzed C‐N cross‐coupling. In contrast to the conventional approach, the open‐shell character is retained allowing quantitative yield of the radical. The obtained dinaphthocarbazole and diphenanthrocarbazol‐functionalized tris(trichlorophenyl)methyl (TTM) radicals can be separated into the respective enantiomers. The resulting chiral radicals exhibit photoluminescence quantum yields as high as 43% and circularly polarized luminescence. Time‐dependent density functional theory (TD‐DFT) calculations support the experimental findings. The newly reported aza[7]helicene‐based radicals hold promise for advanced optoelectronic as well as quantum technological applications.
Tapping the Light Emitting Potential of Chalcogenide Perovskite SrHfS3 via Eu2+ Doping
Authors: Liang Yurun , Li Jiang , Chen Zhipeng , Li Gaoqiang , Li Mengyao , Jia Mochen , Chen Xu , Li Xinjian , Han Yanbing , Shi Zhifeng 
Published: October 2023

AbstractChalcogenide perovskites are an emerging family of perovskite materials, which possess excellent optoelectronic properties comparable with halide perovskites, avoiding the drawbacks of toxicity and poor stability. Due to the superiorities of strong light absorption, direct bandgaps, excellent carrier transport abilities, high defect tolerance, robust stability, and non‐toxicity, chalcogenide perovskites have been extensively studied as photovoltaic materials. However, the light emitting potential of chalcogenide perovskites is ignored or less explored. In this work, an Eu2+ doping strategy is proposed to activate the light emitting abilities of chalcogenide perovskite. The synthesized SrHfS3:Eu2+ powder exhibits intense red emission of Eu2+ through the relaxation of 4f65d1 to 4f75d0. The strong interband absorption of SrHfS3, as a distinct character of chalcogenide perovskite, harvests the optical energy and funnels it to the luminescent center Eu2+. Besides, SrHfS3:Eu2+ is characterized by superior semiconducting properties, suggesting its strong potential as suitable emitters in light‐emitting diodes. Moreover, the obtained SrHfS3:Eu2+ powder and its luminescence properties remain stable under ultraviolet irradiation, water, and high temperature testing. The above observations open a new frontier for exploring luminescent chalcogenide perovskites, highlighting their great potential in lighting and displays, rather than being limited to photovoltaic devices.
Research Progress on Naphthalimide Fluorescent Probes
Authors: Xu Haiyan , Xiao Yinling , Liu Ying‐Guo , Sun Wen 
Published: October 2023

AbstractNaphthalimide derivatives are attracting increasing attention as fluorescent probes due to their excellent modifiability and photophysical properties. Their large, rigid coplanar structures and conjugated systems enable easy generation of fluorescence. The imide units and bromonaphthalene functionality offer facile and concise modification pathways in preparing amenable probes for different metal cations, anions, small molecules, and organelles. Therefore, naphthalimide probes have great potential for application in research fields, such as analytical chemistry, cell biology, and clinical diagnosis.
Type 2 Diabetes Mellitus Mediated Oxidative Stress in Bone Tissues and Novel Challenges for Biomaterials
Authors: Wang Ruideng , Su Shilong , Chen Zhengyang , Zhou Fang 
Published: October 2023

AbstractType 2 diabetes mellitus is a chronic metabolic disease which can adversely affect the skeletal system, causing detrimental bone effects such as bone quality deterioration, loss of bone strength, increased fracture risk, and impaired bone healing. One of the major mechanisms is the increase in T2DM‐induced oxidative stress which results in an imbalance in bone remodeling and affects bone metabolism and bone regeneration. Recently, ROS‐scavenging biomaterials have been identified as a type of promising therapeutic substance to alleviate oxidative stress in tissue microenvironment. The aim of this review is to elaborate T2DM mediated oxidative stress in bone tissues and current application of ROS‐scavenging biomaterials in bone tissue engineering which provides a novel insight into biomaterials in diabetic bone tissue.
A Sustainable Method for Removal of the Full Range of Liquid and Solid Hydrocarbons from Water Including Up‐ and Recycling
Authors: Gaß Henrik , Sarcletti Marco , Müller Lukas , Hübner Sabine , Yokosawa Tadahiro , Park Hyoungwon , Przybilla Thomas , Spiecker Erdmann , Halik Marcus 
Published: October 2023

AbstractBeyond their CO2 emittance when burned as fuels, hydrocarbons (HCs) serve as omnipresent raw materials and commodities. No matter if as liquid oil spills or the endless amounts of plastic roaming the oceans, HCs behave as persistent pollutants with water as main carrier to distribute. Even if their general chemical structure [‐(CH2)n‐] is quite simple, the endless range of n leads to contaminations of different appearances and properties. A water remediation method based on superparamagnetic iron oxide nanoparticles (SPIONs) modified with self‐assembled monolayers of alkyl phosphonic acid derivatives is presented. These molecules enable the SPIONs to non‐covalently bind HCs, independently from the molecular weight, size and morphology. The attractive interaction is mainly based on hydrophobic and Coulomb interaction, which allows recycling of the SPIONs. The superparamagnetic core allows a simple magnetic collection and separation from the water phase which makes it a promising addition to wastewater treatment. Agglomerates of collected plastic “waste” even exhibit superior adsorption properties for crude oil, another hydrocarbon waste which gives these collected wastes a second life. This upcycling approach combined with presented recycling methods enables a complete recycling loop.
A Supertough and Highly‐Conductive Nano‐Dipole Doped Composite Polymer Electrolyte with Hybrid Li+‐Solvation Microenvironment for Lithium Metal Batteries
Authors: Lv Shanshan , He Xuewei , Ji Zhongfeng , Yang Sifan , Feng Lanxiang , Fu Xuewei , Yang Wei , Wang Yu 
Published: October 2023

AbstractAchieving solid polymer electrolytes with ceramic‐like fast single‐ion conduction behavior, separator‐required mechanical properties, and good lithium‐dendrite suppression capability is essential but extremely challenging for the practical success of solid‐state lithium‐metal batteries. The key to overcome this long‐standing bottleneck is to rationally design the Li+‐transport microenvironment inside the polymeric ion‐conductors. Herein, the concept of a nano‐dipole doped composite polymer electrolyte (NDCPE) is proposed using surface‐charged halloysite nanotubes (d‐HNTs) as the dopant to achieve a Li+‐transport‐friendly microenvironment in poly(vinylidene fluoride) (PVDF) based quasi‐solid electrolytes. Results show that the d‐HNTs doping can immobilize the anions and help dissociate the lithium salt, which leads to an advanced dynamic Li+‐interface yielding both a high Li+‐transference number (0.75 ± 0.04) and ionic conductivity (0.29 ± 0.04 mS cm−1 @R.T.). Moreover, compared with the commercial separator, the NDCPE thin‐film shows similar toughness, mechanical strength, and puncture resistance, but much superior capability for stabilizing the lithium‐metal anode. To understand the possible doping mechanism, a hybrid Li+‐solvation model combining the surface charges of the nanofiller, absorbed solvent molecules, and absorbed polymer chain unit is proposed and discussed for guiding the future studies on advanced hybrid solid polymer electrolytes.
Food retailing in developing economies: Review of empirical insights and new directions
Authors: Richards Timothy J. , Pasirayi Simba 
Published: October 2023

AbstractFood retailing in developing economies has undergone significant transformations over the past three decades. Progressing in three waves across regions like Latin America, Asia, Africa, and beyond, food retailers have transitioned from traditional open markets to modern supermarkets akin to those in more developed economies. In this article, we provide an overview of the structure of food retailing in developing economies and examine the empirical literature that delves into the reasons behind the evolution of retailers in developing countries worldwide, as well as their impact on suppliers and consumers. We propose avenues for future research, building upon an empirical framework that recognizes the consumer‐driven nature of retail evolution and how the structure of retailing develops as an equilibrium outcome within a dynamic, imperfectly competitive environment. In conclusion, we identify significant gaps in the existing empirical literature and shed light on emerging questions that are likely to gain importance in the future. [EconLit Citations: D43, L13, M31].
Agricultural specialization activates the industry chain: Implications for rural entrepreneurship in China
Authors: Ji Xing , Chen Jia , Zhang Hongxiao 
Published: October 2023

AbstractAs one of the means of specialization, agricultural outsourcing is regarded as a breakthrough point for agricultural efficiency improvement and rural economic growth by many developing countries. From the perspective of the interest linkage across the entire agricultural industry chain, the potential entrepreneurial effects of agricultural outsourcing have rarely been discussed. The study innovatively treats a Chinese policy as a quasi‐natural experiment, uses cutting‐edge econometric methods to make rigorous causal inferences, and addresses the difficulty of quantifying agricultural outsourcing. We find that agricultural outsourcing significantly increases rural entrepreneurship activity, with an increase of 9.1% of the rural population working for rural private enterprises and rural self‐employed businesses. From the perspective of heterogeneity, the entrepreneurial effect of agricultural outsourcing is more impressive in nonmajor grain‐producing areas. In addition, agricultural outsourcing mainly promotes opportunistic entrepreneurship. Influencing mechanisms include industrial chain extension, off‐farm employment and credit access. Accordingly, we suggest that policymakers take agricultural outsourcing as a starting point to promote rural innovation and entrepreneurship to complete industrial upgrading and transformation. [EconLit Citations: D13, L26, Q16].