bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Innovative Sunlight‐Driven Device for Photocatalytic Drugs Degradation: from laboratory‐ to real‐Scale Application. A First Step Toward Vulnerable Communities
Authors: Galloni Melissa Greta , Falletta Ermelinda , Mahdi Milad , Cerrato Giuseppina , Giordana Alessia , Boffito Daria Camilla , Bianchi Claudia Letizia 
Published: February 2024

AbstractFreshwater represents one of the most precious resources on the planet, so it is fundamental to preserve it. In this work, an innovative sunlight‐driven device composed of bismuth oxybromide (BiOBr) grown on a material derived from natural sources, i.e., Lightweight Expanded Clay Aggregates (LECA), is developed to clean surface waters under natural solar light irradiation. For this purpose, the photodegradation of two non‐steroidal anti‐inflammatory drugs, ibuprofen, and diclofenac, is investigated under varying operative conditions. Laboratory‐ and real‐scale experiments reveal that the fabricated floating BiOBr/LECA photocatalyst fully degrades diclofenac, whereas limited abatement of ibuprofen is observed. Based on the identification of specific transformation products (TPs) during the degradation, this behavior seems to be strongly related to the different structures of the two drugs. In fact, the main TP produced during diclofenac degradation derives from dechlorination and ring condensation: this type of photocatalytic degradation pathway is generally favored over the C─C bonds's cleavage, which is a unique possibility for IBU abatement. Moreover, the potential partial adsorption of these species on the photocatalyst's active sites can cause their deactivation. Finally, reusability tests demonstrate the high stability of the floating composite.
Catalytic Asymmetric Difluoroalkylation Using In Situ Generated Difluoroenol Species as the Privileged Synthon
Authors: Xie Xiongda , Dong Shanliang , Hong Kemiao , Huang Jingjing , Xu Xinfang 
Published: February 2024

AbstractA robust and practical difluoroalkylation synthon, α,α‐difluoroenol species, which generated in situ from trifluoromethyl diazo compounds and water in the presence of dirhodium complex, is disclosed. As compared to the presynthesized difluoroenoxysilane and in situ formed difluoroenolate under basic conditions, this difluoroenol intermediate displayed versatile reactivity, resulting in dramatically improved enantioselectivity under mild conditions. As demonstrated in catalytic asymmetric aldol reaction and Mannich reactions with ketones or imines in the presence of chiral organocatalysts, quinine‐derived urea, and chiral phosphoric acid (CPA), respectively, this relay catalysis strategy provides an effective platform for applying asymmetric fluorination chemistry. Moreover, this method features a novel 1,2‐difunctionalization process via installation of a carbonyl motif and an alkyl group on two vicinal carbons, which is a complementary protocol to the metal carbene gem‐difunctionalization reaction.
Batch Fabrication and Interface Stabilization Accelerate Application of Skutterudite Thermoelectric Module for Power Generation
Authors: Shi Wenjing , Qin Dandan , Sun Yuxin , Wu Hao , Tong Haoyang , Xie Liangjun , Liu Zihang , Zhang Qian , Cai Wei , Guo Fengkai , Sui Jiehe 
Published: February 2024

AbstractTo achieve the commercial application of high‐performance skutterudite (SKD) thermoelectric (TE) devices, breakthroughs in the batch fabrication of TE material and the realization of its stable bonding to the barrier layer are necessary. In this work, the large‐scale SKD bulks with excellent TE performance and decent homogeneity are prepared by melt‐spinning (MS) combined with a hot pressing process. Then, a modified two‐step sintering method is employed to effectively suppress the degree of initial interfacial reaction, resulting in a barrier layer/SKD joint that exhibits low contact resistivity (≈2µΩ·cm2) and high bonding strength (≈30 MPa) with no significant change after aging at 773 K for 30 days. Encouragingly, the joints welded with Mo50Cu50 electrodes also show high stability under the same aging conditions. Finally, the as‐fabricated 8‐pair module shows a highly competitive conversion efficiency of 9% under a temperature difference of 580 K. In addition, during a 360 h aging test with hot‐side temperature of 773 K, the module shows excellent stability. Overall, this work paves the way for batch fabrication of high‐performance SKD using MS and lays a solid foundation for the stable operation of SKD‐based modules.
In Situ Fabrication of Graphdiyne Nanoisland Anchored Ti3C2Tx Film to Accelerate Intercalation Pseudocapacitance Kinetics
Authors: Wu Danni , Zhang Yuman , Man Zengming , Zhang Haiyang , Zhu Xiaolin , Ding Jing , Xu Jianhong , Bao Ningzhong , Lu Wangyang 
Published: February 2024

AbstractA key challenge in flexible supercapacitor is balancing the trade‐off between high capacity and fast charging ability caused by dense structure‐induced sluggish ionic diffusion and storage dynamics. Herein, a hydrogen‐rich graphdiyne (GDY)–Ti3C2Tx electrode is reported with tunable interlayer spacing, abundant active sites, and extensive charge storage nanochannels. In particular, the GDY–Ti3C2Tx (12.6 wt.%) electrode has a remarkable volumetric capacitance (2296 F cm−3 at 1 A cm−3) and fast charging behavior (1262 F cm−3 at 50 A cm−3) resulting from the shortened transport pathways, enhanced ionic diffusion rate, and facilitated electrolyte mass transport. Moreover, an all‐solid‐state supercapacitor (ASSC) delivers a high volumetric energy density of 65.6 mWh cm−3, as well as long‐term deformable cyclic stability and high capacitance retention properties under harsh conditions. Density functional theory calculations and molecular dynamic simulation demonstrate the fast electronic responsiveness of the GDY–Ti3C2Tx heterostructure owning to the stronger H+ electrostatic attraction, lower migration resistance, and accelerated intercalation pseudocapacitance kinetics. In situ X‐ray diffraction reveals that a stable Ti─O─C bond bridged organic–inorganic heterostructure can tolerate the repeated high‐current charge/discharge cycling process. The state‐of‐the‐art ASSC delivers multiple functional outputs and shows great potential for efficient energy supply in practical applications.
Self‐Adaptive Hierarchical Hosts with Switchable Repulsive Shielding for Dendrite‐Free Zinc‐Ion Batteries
Authors: Lin Dewu , Shi Dehuan , Zhu Anquan , Yang Chengkai , Zhang Tian , Liu Kai , Liu Kunlun , Hong Guo , Zhang Wenjun 
Published: February 2024

AbstractThe engineering of anode‐electrolyte interphase for highly reversible and dendrite‐free Zn plating‐stripping continues to pose a significant challenge in the progression of aqueous Zn‐ion batteries (AZIBs). In this study, a novel approach is introduced that involves the design of a hierarchical carbon nanotube (CNT)‐based host through functionalization with cetyltrimethylammonium cations (CTA+). This hierarchical host enables dynamically switchable repulsive shielding to regulate Zn plating. The CNT scaffold, featured with high flexibility and conductivity, facilitates expandable accommodation of continuous Zn plating. Concurrently, the entangled CTA+ cations, acting as manipulators to form switchable repulsive shields, dynamically suppress the growth of Zn dendrites, and result in uniform Zn plating within cationic CNT (C‐CNT) hosts. The cationic shielding effect is further elucidated through density functional theory calculations. By incorporating the self‐adaptive C‐CNT host, Zn symmetric cells exhibit an impressively stable cycling lifespan exceeding 6500 h at 1 mA·cm−2 and achieve a cumulative capacity of 6000 mAh·cm−2 at 4 mA·cm−2. Full batteries, by coupling the C‐CNT@Zn anode and MnO2 cathode, demonstrate an 88% capacity retention after 2000 cycles at 2 A·g−1. The design of the self‐adaptive C‐CNT host offers a promising approach in electrode‐electrolyte interphase engineering toward the practical applications of Zn‐based energy storage systems.
A review of soil erosion modeling in Nigeria using the Revised Universal Soil Loss Equation model
Authors: Ezeh Christopher Uche , Igwe Ogbonnaya , Asare Mensah Yaw , Ndulue Dominic C. , Ayadiuno Romanus U. , Preko Kwasi 
Published: February 2024

AbstractSoil erosion is a severe soil degradation problem that endangers the actualization of Sustainable Development Goals. It affects agricultural production by reducing soil fertility via topsoil translocation, leading to soil quality deterioration. A review of soil erosion modeling using the Revised Universal Soil Loss Equation (RUSLE) model shows that Nigeria lags behind other developing countries like Ethiopia despite the massive improvements provided by remote sensing and geographic information system (GIS) technologies. Fewer than 50 articles were found on the Google Scholar search engine that used the RUSLE model for empirical studies on soil erosion. Only four research articles were found on the ScienceDirect website. Additionally, there were differences in the findings from studies across Nigeria. Such disparities were due to differences in the approaches used to estimate key factors in the RUSLE model. Therefore, we recommend that the Ministries of Agriculture and Environment take soil erosion research seriously by adopting proactive soil conservation and management measures. Ensemble models can be used including machine learning approaches rather than focusing mainly on structural intervention. In addition, there should be a harmonized look‐up table for the cover management factor and conservation practices factor that fairly represent the various ecoclimatic regions. The limitations to the model's use are highlighted, and a way forward is suggested.
Single agent subcutaneous blinatumomab for advanced acute lymphoblastic leukemia
Authors: Jabbour Elias , Zugmaier Gerhard , Agrawal Vaibhav , Martínez‐Sánchez Pilar , Rifón Roca José J. , Cassaday Ryan D. , Böll Boris , Rijneveld Anita , Abdul‐Hay Maher , Huguet Françoise , Cluzeau Thomas , Díaz Mar Tormo , Vucinic Vladan , González‐Campos José , Rambaldi Alessandro , Schwartz Stefan , Berthon Céline , Hernández‐Rivas Jesús María , Gordon Paul R. , Brüggemann Monika , Hamidi Ali , Chen Yuqi , Wong Hansen L. , Panwar Bharat , Katlinskaya Yuliya , Markovic Ana , Kantarjian Hagop 
Published: February 2024

AbstractBlinatumomab is a BiTE® (bispecific T‐cell engager) molecule that redirects CD3+ T‐cells to engage and lyse CD19+ target cells. Here we demonstrate that subcutaneous (SC) blinatumomab can provide high efficacy and greater convenience of administration. In the expansion phase of a multi‐institutional phase 1b trial (ClinicalTrials.gov, NCT04521231), heavily pretreated adults with relapsed/refractory B‐cell acute lymphoblastic leukemia (R/R B‐ALL) received SC blinatumomab at two doses: (1) 250 μg once daily (QD) for week 1 and 500 μg three times weekly (TIW) thereafter (250 μg/500 μg) or (2) 500 μg QD for week 1 and 1000 μg TIW thereafter (500 μg/1000 μg). The primary endpoint was complete remission/complete remission with partial hematologic recovery (CR/CRh) within two cycles. At the data cutoff of September 15, 2023, 29 patients were treated: 14 at the 250 μg/500 μg dose and 13 at 500 μg/1000 μg dose. Data from two ineligible patients were excluded. At the end of two cycles, 12 of 14 patients (85.7%) from the 250 μg/500 μg dose achieved CR/CRh of which nine patients (75.0%) were negative for measurable residual disease (MRD; <10−4 leukemic blasts). At the 500 μg/1000 μg dose, 12 of 13 patients (92.3%) achieved CR/CRh; all 12 patients (100.0%) were MRD‐negative. No treatment‐related grade 4 cytokine release syndrome (CRS) or neurologic events (NEs) were reported. SC injections were well tolerated and all treatment‐related grade 3 CRS and NEs responded to standard‐of‐care management, interruption, or discontinuation. Treatment with SC blinatumomab resulted in high efficacy, with high MRD‐negativity rates and acceptable safety profile in heavily pretreated adults with R/R B‐ALL.
Eltrombopag improves platelet engraftment after haploidentical bone marrow transplantation: Results of a Phase II study
Authors: Ahmed Sairah , Bashir Qaiser , Bassett Roland L. , Ullah Fauzia , Aung Fleur , Valdez Benigno C. , Alousi Amin M. , Hosing Chitra , Kebriaei Partow , Khouri Issa , Marin David , Nieto Yago , Olson Amanda , Oran Betul , Qazilbash Muzaffar H. , Rezvani Katayoun , Mehta Rohtesh , Shpall Elizabeth J. , Ciurea Stefan , Andersson Borje S. , Champlin Richard E. , Popat Uday R. 
Published: February 2024

AbstractSlow platelet recovery frequently occurs after haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) with bone marrow graft and post‐transplant cyclophosphamide (PCy)‐based graft‐versus‐host disease (GVHD) prophylaxis. Improved platelet recovery may reduce the need for transfusions and improve outcomes. We investigated the safety and efficacy of eltrombopag, a thrombopoietin receptor agonist, at enhancing platelet recovery post‐haplo‐HSCT. The prospective study included patients ≥18 years of age who received haplo‐HSCT with bone marrow graft and PCy. Patients received eltrombopag 300 mg/day starting on Day +5. The primary objective was to estimate platelet engraftment (>50 000/μL by Day 60). In a post hoc analysis, they were compared to a contemporary matched control group who did not receive eltrombopag. One hundred ten patients were included in the analysis (30 eltrombopag and 80 control). Seventy‐three percent and 50% of patients in the eltrombopag group and control group, respectively, attained >50 000/μL platelet count by Day 60 (p = .043). No eltrombopag‐related grade ≥4 adverse events were observed. Median time to platelet recovery (>20 000/μL) was 29 days with eltrombopag and 31 days for controls (p = .022), while its cumulative incidence was 90% (95% confidence interval [CI]: 78%–100%) with eltrombopag versus 67.5% (95% CI: 57%–78%) for controls (p = .014). Number of platelet transfusions received, overall survival, progression‐free survival, GVHD rate, relapse rate, and non‐relapse mortality were similar between groups. Overall, eltrombopag is safe and improves platelet recovery in patients undergoing haplo‐HSCT with bone marrow graft and PCy.
Development of specific growth charts for children with Fanconi anemia
Authors: Barbus Crystal , Rayannavar Arpana , Miller Bradley S. , Jenkins Mica J. , Addo O. Yaw , Rayes Ahmad , Ahrweiler Natasha , Olson Alisha , Pohlkamp Zachary , Wagner John E. , MacMillan Margaret L. 
Published: February 2024

AbstractPatients with Fanconi anemia (FA) are often perceived to have poor growth when general population growth curves are utilized. We hypothesize that FA patients have unique growth and aimed to create FA‐specific growth charts. Height and weight data from ages 0 to 20 years were extracted from medical records of patients treated at the Fanconi Anemia Comprehensive Care Clinic at the University of Minnesota. Height, weight, and BMI growth curves were generated and fitted to reference percentiles using the Lambda‐Mu‐Sigma method. FA‐specific percentiles were compared to WHO standards for ages 0–2 and CDC references for ages 2–20. In FA males, the 50th height‐ and weight‐for‐age percentiles overlap with the 3rd reference percentile. In FA females, only the 50th height‐for‐age percentile overlaps with the 3rd reference percentile. For weight, FA females show progressive growth failure between 6 and 24 months followed by stabilization around the 50th percentile. The FA BMI‐for‐age percentiles show similar patterns to the weight‐for‐age percentiles but have different timing of onset of adiposity rebound and broader variability in females. Growth in FA patients follows a different trajectory than available normative curves. FA‐specific growth charts may be useful to better guide accurate growth expectations, evaluations, and treatment.
Funktionsgewinn recycelbarer Photoschalter: Gleichzeitige reversible Substitution und Erzeugung von Photochromie
Authors: Zitzmann Max , Fröhling Matthias , Dube Henry 
Published: February 2024

AbstractDie Verwendung von molekularen Photoschaltern hat sich aufgrund der präzisen Kontrolle, die sie über das Verhalten von Materie auf kleinsten Maßstäben ermöglichen, in nahezu allen Bereichen der reinen und angewandten Chemie verbreitet. Photoschalter besitzen mindestens zwei strukturell und/oder elektronisch verschiedene Zustände. Um diese für eine spezifische Anwendung anzupassen, ist eine weitere Funktionalisierung des Chromophors erforderlich. In dieser Arbeit präsentieren wir ein neues Konzept für die Erzeugung und Verwendung von molekularen Photoschaltern, welches nicht nur die gleichzeitige Etablierung von Photochromie und Funktionalisierung, sondern auch die vollständige Recyclingfähigkeit einer nicht photochromen Vorstufe ermöglicht. Unter Verwendung einer effizienten und reversiblen Ammoniumsalzbildung wird eine funktionelle Gruppe in eine symmetrische Vorstufe eingeführt und gleichzeitig ein starkes elektronisches Donor‐Akzeptor‐System in der Struktur erzeugt. Die daraus resultierende Desymmetrisierung führt zu einem effizienten Photoschalter, bei dem die funktionelle Gruppe anschließend durch einen einfachen Erhitzungsschritt vollständig entfernt werden kann, wobei die symmetrische Vorstufe für eine weitere Funktionalisierung zurückgewonnen wird. Schließlich zeigen wir die Durchführbarkeit dieses Konzepts für zwei aufeinanderfolgende Funktionalisierungs‐, Photoschalt‐ und Recyclingschritte. Dieses Konzept bietet ein großes Potenzial in allen chemischen Forschungs‐ und Anwendungsbereichen, insbesondere für die Entwicklung von responsiven und reprogrammierbaren Materialien, Photoschaltermarkierungen ohne Hintergrundstörung, sowie in der nachhaltigen Chemie.
Cobalt‐based Co3Mo3N/Co4N/Co Metallic Heterostructure as a Highly Active Electrocatalyst for Alkaline Overall Water Splitting
Authors: Liu Yuanwu , Wang Lirong , Hübner René , Kresse Johannes , Zhang Xiaoming , Deconinick Marielle , Vaynzof Yana , Weidinger Inez M. , Eychmüller Alexander 
Published: February 2024

AbstractAlkaline water electrolysis holds promise for large‐scale hydrogen production, yet it encounters challenges like high voltage and limited stability at higher current densities, primarily due to inefficient electron transport kinetics. Herein, a novel cobalt‐based metallic heterostructure (Co3Mo3N/Co4N/Co) is designed for excellent water electrolysis. In operando Raman experiments reveal that the formation of the Co3Mo3N/Co4N heterointerface boosts the free water adsorption and dissociation, increasing the available protons for subsequent hydrogen production. Furthermore, the altered electronic structure of the Co3Mo3N/Co4N heterointerface optimizes ΔGH of the nitrogen atoms at the interface. This synergistic effect between interfacial nitrogen atoms and metal phase cobalt creates highly efficient active sites for the hydrogen evolution reaction (HER), thereby enhancing the overall HER performance. Additionally, the heterostructure exhibits a rapid OH− adsorption rate, coupled with great adsorption strength, leading to improved oxygen evolution reaction (OER) performance. Crucially, the metallic heterojunction accelerates electron transport, expediting the afore‐mentioned reaction steps and enhancing water splitting efficiency. The Co3Mo3N/Co4N/Co electrocatalyst in the water electrolyzer delivers excellent performance, with a low 1.58 V cell voltage at 10 mA cm−2, and maintains 100 % retention over 100 hours at 200 mA cm−2, surpassing the Pt/C||RuO2 electrolyzer.
Terminal Copper Nitrenoid Formation and Reactivity Induced by Absorption to an Antenna Ligand
Authors: de Kler Noël , Pereverzev Aleksandr Y. , Roithová Jana 
Published: February 2024

AbstractCopper nitrenoids are key intermediates in copper‐catalyzed direct C−H amination reactions. Further development of this important reaction relies on knowing the properties and reactivity of the nitrenoid intermediates. This work utilizes antenna ligands to form copper nitrenoid complexes and monitor the consecutive C−H amination reactions under well‐defined single‐molecule conditions in the gas phase. The [Cu(Lphoto)(Lazide)]+ precursors (Lphoto is a bidentate antenna ligand, and Lazide is an organic azide) were stored in an ion trap at 3.5 K and irradiated by visible light, which resulted in denitrogenation of the complex. Further irradiation of the copper nitrenoid led to the consecutive C−H amination of the antenna ligand. The nitrenoid complexes, as well as the products of the C−H amination, were characterized by helium tagging IRPD spectroscopy, and the mechanism was described by DFT calculations. This research demonstrates that the antenna ligands can be used to promote the denitrogenation of metal azides in the gas phase and also channel the internal energy to promote further reactivity, which opens a new way to study the reactivity of highly reactive species under well‐defined conditions.
Achieving High‐Temperature Phosphorescence by Organic Cocrystal Engineering
Authors: Singh Manjeet , Shen Kang , Ye Wenpeng , Gao Yanhua , Lv Anqi , Liu Kun , Ma Huili , Meng Zhengong , Shi Huifang , An Zhongfu 
Published: February 2024

AbstractOrganic phosphors offer a promising alternative in optoelectronics, but their temperature‐sensitive feature has restricted their applications in high‐temperature scenarios, and the attainment of high‐temperature phosphorescence (HTP) is still challenging. Herein, a series of organic cocrystal phosphors are constructed by supramolecular assembly with an ultralong emission lifetime of up to 2.16 s. Intriguingly, remarkable stabilization of triplet excitons can also be realized at elevated temperature, and green phosphorescence is still exhibited in solid state even up to 150 °C. From special molecular packing within the crystal lattice, it has been observed that the orientation of isolated water cluster and well‐controlled molecular organization via multiple interactions can favor the structural rigidity of cocrystals more effectively to suppress the nonradiative transition, thus resulting in efficient room‐temperature phosphorescence and unprecedented survival of HTP.