bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robustness of hypofractionated breast radiotherapy after breast-conserving surgery with free breathing
Authors: Chen Kunzhi , Sun Wuji , Han Tao , Yan Lei , Sun Minghui , Xia Wenming , Wang Libo , Shi Yinghua , Ge Chao , Yang Xu , Li Yu , Wang Huidong 
Published: October 2023

PurposeThis study aimed to evaluate the robustness with respect to the positional variations of five planning strategies in free-breathing breast hypofractionated radiotherapy (HFRT) for patients after breast-conserving surgery.MethodsTwenty patients who received breast HFRT with 42.72 Gy in 16 fractions were retrospectively analyzed. Five treatment planning strategies were utilized for each patient, including 1) intensity-modulated radiation therapy (IMRT) planning (IMRTpure); 2) IMRT planning with skin flash tool extending and filling the fluence outside the skin by 2 cm (IMRTflash); 3) IMRT planning with planning target volume (PTV) extended outside the skin by 2 cm in the computed tomography dataset (IMRTePTV); 4) hybrid planning, i.e., 2 Gy/fraction three-dimensional conformal radiation therapy combined with 0.67 Gy/fraction IMRT (IMRThybrid); and 5) hybrid planning with skin flash (IMRThybrid-flash). All plans were normalized to 95% PTV receiving 100% of the prescription dose. Six additional plans were created with different isocenter shifts for each plan, which were 1 mm, 2 mm, 3 mm, 5 mm, 7 mm, and 10 mm distally in the X (left-right) and Y (anterior-posterior) directions, namely, (X,Y), to assess their robustness, and the corresponding doses were recalculated. Variation of dosimetric parameters with increasing isocenter shift was evaluated.ResultsAll plans were clinically acceptable. In terms of robustness to isocenter shifts, the five planning strategies followed the pattern IMRTePTV, IMRThybrid-flash, IMRTflash, IMRThybrid, and IMRTpure in descending order. V95% of IMRTePTV maintained at 99.6% ± 0.3% with a (5,5) shift, which further reduced to 98.2% ± 2.0% with a (10,10) shift. IMRThybrid-flash yielded the robustness second to IMRTePTV with less risk from dose hotspots, and the corresponding V95% maintained &gt;95% up until (5,5).ConclusionConsidering the dosimetric distribution and robustness in breast radiotherapy, IMRTePTV performed best at maintaining high target coverage with increasing isocenter shift, while IMRThybrid-flash would be adequate with positional uncertainty&lt;5 mm.
Ketamine promptly normalizes excess norepinephrine and enhances dopamine neuronal activity in Wistar Kyoto rats
Authors: Daniels Stephen , El Mansari Mostafa , Hamoudeh Rami , Blier Pierre 
Published: October 2023

Ketamine acts primarily by blocking the N-methyl-D-aspartate (NMDA) receptor at the phencyclidine site. The rapid antidepressant properties of ketamine were demonstrated in the clinic and several behavioral models of depression in rodents. We hypothesized that the normalization of abnormal activity of monoamine neurons in Wistar Kyoto (WKY) rats contributes to the rapid antidepressant effects of ketamine. A single administration of ketamine (10 mg/kg, i. p) or saline was administered to anesthetized WKY rats beforein vivoelectrophysiological recordings of dorsal raphe nucleus (DRN) serotonin (5-HT), locus coeruleus (LC) norepinephrine (NE) and ventral tegmental area (VTA) dopamine (DA) neuronal activity. Pyramidal neurons from the medial prefrontal cortex (mPFC) were also recorded before and after a ketamine injection. In the VTA, ketamine elicited a significant increase in the population activity of DA neurons. This enhancement was consistent with findings in other depression-like models in which such a decreased population activity was observed. In the LC, ketamine normalized increased NE neuron burst activity found in WKY rats. In the DRN, ketamine did not significantly reverse 5-HT neuronal activity in WKY rats, which is dampened compared to Wistar rats. Ketamine did not significantly alter the neuronal activity of mPFC pyramidal neurons. These findings demonstrate that ketamine normalized NE neuronal activity and enhanced DA neuronal activity in WKY rats, which may contribute to its rapid antidepressant effect.
Discovery of inhibitors of protein tyrosine phosphatase 1B contained in a natural products library from Mexican medicinal plants and fungi using a combination of enzymatic and in silico methods**
Authors: Díaz-Rojas Miriam , González-Andrade Martin , Aguayo-Ortiz Rodrigo , Rodríguez-Sotres Rogelio , Pérez-Vásquez Araceli , Madariaga-Mazón Abraham , Mata Rachel 
Published: October 2023

This work aimed to discover protein tyrosine phosphatase 1B (PTP1B) inhibitors from a small molecule library of natural products (NPs) derived from selected Mexican medicinal plants and fungi to find new hits for developing antidiabetic drugs. The products showing similar IC50 values to ursolic acid (UA) (positive control, IC50 = 26.5) were considered hits. These compounds were canophyllol (1), 5-O-(β-D-glucopyranosyl)-7-methoxy-3′,4′-dihydroxy-4-phenylcoumarin (2), 3,4-dimethoxy-2,5-phenanthrenediol (3), masticadienonic acid (4), 4′,5,6-trihydroxy-3′,7-dimethoxyflavone (5), E/Z vermelhotin (6), tajixanthone hydrate (7), quercetin-3-O-(6″-benzoyl)-β-D-galactoside (8), lichexanthone (9), melianodiol (10), and confusarin (11). According to the double-reciprocal plots, 1 was a non-competitive inhibitor, 3 a mixed-type, and 6 competitive. The chemical space analysis of the hits (IC50 &lt; 100 μM) and compounds possessing activity (IC50 in the range of 100–1,000 μM) with the BIOFACQUIM library indicated that the active molecules are chemically diverse, covering most of the known Mexican NPs’ chemical space. Finally, a structure–activity similarity (SAS) map was built using the Tanimoto similarity index and PTP1B absolute inhibitory activity, which allows the identification of seven scaffold hops, namely, compounds 3, 5, 6, 7, 8, 9, and 11. Canophyllol (1), on the other hand, is a true analog of UA since it is an SAR continuous zone of the SAS map.
Predictors of quality of childcare centers in low-income settings: findings from a cross-sectional study in two Nairobi slums
Authors: Nampijja Margaret , Langat Nelson , Oloo Linda , Okelo Kenneth , Muendo Ruth , Kiyeng Martin , Amboka Patrick , Abboah-Offei Mary , Ray Anna , Kitsao-Wekulo Patricia , Kimani-Murage Elizabeth W. , Elsey Helen 
Published: October 2023

BackgroundRapid urbanization and increased women’s involvement in paid work have contributed to the upsurge of informal childcare centers, especially in low-income settings where quality is a major issue. However, there are limited data on the factors associated with the quality of childcare centers in informal settlements in Africa.MethodsWe conducted a quantitative observation and questionnaire survey of 66 childcare centers to identify the factors associated with the quality of childcare services in two informal settlements (Korogocho and Viwandani) in Nairobi. The quality of the centers (outcome variable) was assessed using a locally developed tool. Data on center characteristics including type, size, location, length of operation, charges, and number of staff were collected. Center providers’ knowledge, attitude, and practices (KAP) in childcare were assessed through a questionnaire, focusing on nurturing care and business management. Data were described using means and standard deviation or frequencies and percentages. Associations between quality center score (outcome variable) and other variables were examined using multivariable linear regression to identify potential predictors of the quality of the center environment.FindingsA total of 129 childcare centers were identified and categorized as home-based (n = 45), center-based (n = 14), school-based (n = 61), and church-based (n = 9). The number of home-based centers was particularly high in Viwandani (n = 40; 52%). Only 9% of home-based centers reported any external support and 20% had any training on early childhood development. Of the 129 centers, 66 had complete detailed assessment of predictors of quality reported here. Unadjusted linear regressions revealed associations between quality of childcare center and center providers’ education level, type of center, support received, caregiver–child ratio, number of children in the center, and center providers’ KAP score (p &lt; 0.05). However, in the multivariable regression, only higher levels of center provider KAP (β = 0.51; 95% CI: 0.18, 0.84; p = 0.003) and center type (β = 8.68; 95% CI: 2.32, 15.04; p = 0.008) were significantly associated with center quality score.ImplicationOur results show that center providers’ knowledge and practices are a major driver of the quality of childcare centers in informal settlements in Nairobi. Interventions for improving the quality of childcare services in such settings should invest in equipping center providers with the necessary knowledge and skills through training and supportive supervision.
Body composition in male lifelong trained strength, sprint and endurance athletes and healthy age-matched controls
Authors: Walker Simon , von Bonsdorff Mikaela , Cheng Sulin , Häkkinen Keijo , Bondarev Dmitriy , Heinonen Ari , Korhonen Marko T. 
Published: October 2023

IntroductionAging involves many physiological processes that lead to decreases in muscle mass and increases in fat mass. While regular exercise can counteract such negative body composition outcomes, masters athletes maintain high levels of exercise throughout their lives. This provides a unique model to assess the impact of inherent aging. The present study compared lean mass and fat mass in young and masters athletes from different sports to age-matched non-athletic individuals.MethodsParticipants included young (20–39 years, n = 109) and older (70–89 years, n = 147) competitive male athletes, and 147 healthy age-matched controls (young = 53, older = 94 males). Athletes were separated into strength (e.g., weightlifters, powerlifters), sprint (e.g., sprint runners, jumpers) and endurance (e.g., long-distance runners, cross-country skiers) athletic disciplines. Body composition was assessed by dual-energy x-ray absorptiometry (DXA). Upper and lower limb lean mass was combined for appendicular lean mass as well as appendicular lean mass index (ALMI; kg/m2). Individuals’ scores were assessed against established cut-offs for low muscle mass, obesity, and sarcopenic obesity to determine prevalence in each group.ResultsALMI was greater in young strength (0.81–2.36 kg/m2, ∼15% and 1.24–2.74 kg/m2, ∼19%) and sprint (95% CI = 0.51–1.61 kg/m2, ∼11% and 0.96–1.97 kg/m2, ∼15%) athletes than in endurance and controls, respectively (all P &lt; 0.001). In masters athletes, only strength athletes had greater ALMI than endurance athletes, but both older strength and sprint athletes had greater ALMI than older controls (0.42–1.27 kg/m2, ∼9% and 0.73–1.67 kg/m2, ∼13%, respectively, both P &lt; 0.001). Fat mass was significantly lower in sprint and endurance athletes compared to strength athletes and controls in both age-groups. Sarcopenic obesity was identified in one young (2%) and eighteen (19%) older controls, while only two older endurance athletes (3%) and one older strength athlete (2%) were identified.DiscussionLifelong competitive sport participation leads to lower prevalence of sarcopenic obesity than a recreationally active lifestyle. This is achieved in strength athletes by emphasizing muscle mass, while sprint and endurance athletes demonstrate low fat mass levels. However, all older athlete groups showed higher fat mass than the young groups, suggesting that exercise alone may not be sufficient to manage fat mass.
Influence of Brown Seaweed (Ecklonia maxima) Extract on the Morpho-Physiological Parameters of Melon, Cucumber, and Tomato Plants
Authors: Lefi Elkadri , Badri Mounawer , Hamed Samouna Ben , Talbi Sihem , Mnafgui Wiem , Ludidi Ndiko , Chaieb Mohamed 
Published: October 2023

In this study, we evaluated the impact of brown seaweed extract (Ecklonia maxima) on the morphology and physiology of three different plant species. We conducted experiments using two types of fertilizers: an artificial fertilizer (0.1 g/L) and a biological extract of brown seaweed (Ecklonia maxima) at two concentrations (C1 at 1 mL/L and C2 at 2.5 mL/L). For melon, the application of C1 resulted in significant improvements in photosynthesis parameters, total chlorophyll content, and overall plant growth. When C2 was applied, it further enhanced these parameters, leading to a notable increase in shoot phytomass. In the case of cucumber, C1 led to increased resource allocation towards stems and leaves. Conversely, C2 increased the number of green leaves and contributed to higher shoot phytomass. For tomato plants, the application of C1 resulted in a slight increase in photosynthesis, but it did not significantly impact leaf growth. On the other hand, C2 induced a modest increase in photosynthesis, chlorophyll content, and root growth. In summary, our findings indicate that brown seaweed extract has a discernible influence on the physiology of the studied plants. However, the specific effects on resource allocation largely depend on the plant species and the concentration of the extract applied.
MARKETING STRATEGY FOR ECOTOURISM PRODUCTS IN LABUAN BAJO, EAST NUSA TENGGARA
Authors: Adi Husnaini  
Published: October 2023

Ecotourism is part of sustainable tourism, where special attention is needed regarding environmental, economic, and social sustainability. Sustainable tourism is very much needed in the current era in order to preserve the nature and culture of an area. Sustainable tourism also involves the community fully, so that the impacts can be felt fully by the community directly. The purpose of this paper is to determine the internal and external factors needed to build a marketing strategy at the two research locations as well as to formulate a strategy based on SWOT analysis. The method used is descriptive-qualitative, using interviews, observation, and literature study, using the SWOT analysis technique. The results of this study show that there are several marketing programs that can be implemented in research locations, starting with product packaging, promotion, repositioning, and improving tourism services. Ecotourism destinations, learning from the benchmarking choices of researchers, and targeted marketing are aimed at special interest tourists. A visitor limit is being implemented with the goal of adjusting to the capacity of the conservation environment. so that the marketing strategy that is carried out should not invite mass tourism. However, collaboration and participation from other tourism actors are also needed in the promotion and management of destinations.
Keywords: Environmental analysis, resources, ecotourism
Integrasi Kebiasaan Sako Seng Pada Masyarakat Sikka untuk Meningkatkan Nilai Tanggung Jawab dan Kerja Sama pada Peserta Didik Sekolah Dasar
Authors: Yufrinalis Marianus , Hero Hermus 
Published: October 2023

<p>Tujuan penelitian ini adalah mengintegrasikan nilai-nilai luhur kebiasaan Sako Seng pada masyarakat Kabupaten Sikka di Provinsi NTT ke dalam pembelajaran di sekolah dasar sehingga dapat meningkatkan nilai tanggung jawab dan kerja sama pada peserta didik. Sako Seng merupakan kebiasaan masyarakat Sikka yang mengacu pada semangat gotong-royong dan kerja sama dalam mengelola dan mengolah lahan pertanian atau kebun. Adapun metode penelitian yang digunakan adalah penelitian kualitatif deskriptif. Pengumpulan data dilakukan dengan wawancara, tes, observasi dan studi dokumentasi. Responden ditentukan peneliti yakni kepala sekolah, guru, dan siswa di SDK 025 Kloangrotat. Analisis data dilakukan melalui pengumpulan data, reduksi data, penyajian data dan menarik kesimpulan. Hasil penelitian menunjukkan bahwa dalam pembelajaran di kelas guru telah mampu mengintegrasikan berbagai nilai kearifan lokal seperti kebiasaan Sako Seng ke dalam bahan ajar sehingga mudah dipahami peserta didik dan meningkatkan nilai tanggung jawab, kerja sama serta berimbas pada peningkatan hasil belajar mereka. Selain itu, implementasi berbagai nilai kearifan lokal Sikka juga dilakukan melalui kegiatan ekstrakurikuler peserta didik melalui Program Penguatan Profil Pelajar Pancasila (P5), seperti pentas seni, praktik kerajinan lokal, dan beberapa kegiatan lainnya.</p>
Developing an aviation-based syllabus for PAFU officer-cadets
Authors: Filipczuk-Rosińska Sylwia 
Published: October 2023

ObjectivesThe main objective of the following paper is to present the teaching rationale and premises underlying the development of materials and an aviation-based syllabus designed for officer-cadets of the Polish Air Force University. Additionally, as a practical illustration of implementing content-based instruction in the PAFU classroom, the gradual process underlying the personally developed tasks integrating not only contextualised grammar and vocabulary, but also receptive and productive skills was meticulously described.MethodsSynthesis of theoretical concepts encompassing elements of aviation safety studies – the SHELL model, English teaching methods and approaches and psychology – the theory of Multiple Intelligence was made to outline the authoress’s interdisciplinary approach to teaching English. Comparison was applied to link the process of developing materials to officer-cadets’ flight training. Literature pertaining to syllabus design was analysed to determine the type of the designed aviation-based syllabus. Findings from applying diagnostic surveys were presented to describe officer-cadets’ reception of the aviation-based lesson and syllabus.ResultsThe analysis of both the designed aviation-based syllabus including sample teaching materials and positive feedback obtained from surveys conducted among officer-cadets prove the advisability and necessity for adopting an interdisciplinary approach to teaching officer-cadets at the Polish Air Force University.ConclusionsThe proposed aviation-based syllabus including well-designed materials reflecting an interdisciplinary teaching approach is a comprehensive teaching solution adjusted to officer-cadets’ learning needs and tailored to their military milieu The implementation and further improvement of such an innovative solution is feasible provided more teaching staff is involved in the outlined process.
THE INFLUENCE OF PRODUCT PACKAGING, PROMOTION, AND PRICE TOWARD THE CUSTOMER SATISFACTION THAT LEADS TO THE GREEN ECONOMY ERA IN GARASI OUTLET IN SURABAYA
Authors: Kusmayati Nindya kartika 
Published: October 2023

ABSTRACT : In the modern era as we are today, there are a lot of small micro enterprises in culinary and food industry that compete in order to draw customer’s attention to buy. This research aims to understand and explains whether or not Product Packaging, Promotion, and Price influencing the Customer’s Satisfaction in the era of Green Economy. The method used here is the quantitative one categorized using descriptive approach with Surabaya people as population and sample is taken up randomly from the population. Sample used consists of 31 respondents. This research has normally distributed data, heteroscedasticity and multicollinearity-free, and none of auto-correlation symptoms found. The equation of this research has the form of multiple linear regression as follows; Y= 4,359 + 0,206X1 – 0,159X2 + 0,885X3. Result of the research shows that t test of Product Packaging (X1) and Promotion (X2) do not influence significantly toward the Customer Satisfaction (Y) partially, as it is found that sig value is larger than the alpha (0.05). Meanwhile, Price (X3) influences the Customer Satisfaction (Y) significantly. In F test, it is known that the value of sig is 0.00 which is less than the alpha (0.05) and the F score is 42.257 where this is definitely larger than the F table score which is 2.95 meaning that the three independent variables influence the dependent variable simultaneously.
Keywords: Product Packaging, Promotion, Price, Green Economy
Analisa Cacat Timbul pada Material Aluminium Akibat Pemotongan Menggunakan Laser Cutting
Authors: Karyadi Karyadi , Nanda Rizki Aulia , Suhara Ade 
Published: October 2023

AbstractLaser cutting has been widely used and is growing rapidly in the manufacturing industry, both in the automotive sector and other production fields as needed for fast, precise and accurate cutting processes. Cutting using laser cutting makes it very easy for the production industry to cut steel, aluminum and other materials. However, errors that often occur at this time when input parameters are carried out in the operation of CNC laser cutting often result in defects in the cut material. The purpose of this study was to determine the variation of speed parameters for cutting aluminum alloy type 1050A material with a thickness of 0.8 mm. With these speed variations, it can be seen at what speed the material corresponds to during the laser cutting process. The method in this study was to use an experimental method with variable speeds of 33 mm/s, 55 mm/s and 88 mm/s, then look at the defects that arise and make measurements arising from the flatness of the plate using a digital dial indicator. The results of this study showed that the highest defects were on the average of sections A3 and B3 of 0.012 mm with a plate diameter of 50.2 and 45.2 mm with an aluminum plate thickness of 0.8 mm. At a speed of 33 mm/s, it can be concluded that the appearance of these defects is very small, ranging from 0.004 mm-0.008 mm.Keywords:Arise Defects; Aluminum Alloy; Laser Cutting. AbstrakPemotongan laser cutting telah banyak digunakan dan berkembang pesat di dunia industri manufaktur, baik di bidang otomotif maupun bidang produksi lainya sebagaimana dibutuhkan untuk proses pemotongan secara cepat, tepat dan akurat. Pemotongan menggunakan laser cutting sangat memudahkan bagi para industri produksi dalam memotong sebuah material baja aluminium dan material-material lainnya. Namun kesalahan yang sering terjadi pada saat ini apabila input parameter yang dilakukan dalam pengoperasian CNC laser cutting sering terjadi kecacatan pada material hasil potongan tersebut. Tujuan dari penelitian ini adalah dengan menentukan variasi parameter kecepatan terhadap pemotongan material aluminium alloy tipe 1050A ketebalan 0,8 mm. Dengan variasi kecepatan tersebut dapat dilihat pada kecepatan berapa yang sesuai dengan material tersebut pada saat proses laser cutting. Metode pada penelitian ini adalah menggunakan metode eksperimen dengan variable kecepatan sebesar 33 mm/s, 55 mm/s dan 88 mm/s, selanjutnya melihat cacat timbul dan melakukan pengukuran yang timbul dari kerataan plat menggunakan dial indikator digital. Hasil penelitian ini menunjukkan cacat timbul tertinggi pada rata-rata bagian A3 dan B3 sebesar 0,012 mm dengan diameter plat 50,2 dan 45,2 mm pada ketebalan plat aluminium 0,8 mm. Pada kecepatan 33 mm/s dapat disimpulkan bahwa timbulnya cacat tersebut sangat kecil berkisar antara 0,004 mm-0,008 mm.Kata Kunci: Aluminium Alloy; Cacat Timbul; Laser Cutting