bluuebunny/crossref_metadata_2025_split huggingface dataset:
El aula virtual Moodle en educación superior
Authors: López López Edgar Nelson , Ortiz Ortiz Mary Luz , Leguizamón González Myriam Cecilia 
Published: November 2023

Este libro recoge los resultados del proyecto de investigación denominado; El aula virtual Moodle en la Universidad Pedagógica y Tecnológica de Colombia, práctica e impacto 2010-2014; el cual se desarrolló con el propósito de caracterizar el uso y apropiación del aula virtual en los programas presenciales de la institución en el período en referencia. la metodología de investigación empleada en el estudio fue mixta con enfoque descriptivo, se analizaron variables y conceptos con el propósito de especificar las propiedades relacionadas con la integración pedagógica del Aula Virtual, uso didáctico y nivel de apropiación por parte de docentes y estudiantes. A través de los capítulos se presenta información sobre la conceptualización y evolución de Moodle en la UPTC, luego se describen algunas experiencias a nivel nacional e internacional sobre el uso de este sistema en el contexto educativo; a continuación se esboza la fundamentación teórica en relación con la integración y apropiación de las plataformas virtuales y los resultados de su incorporación en la Universidad. Así mismo, se describen dos experiencias utilizando Moodle en la práctica pedagógica por parte de maestros en formación en instituciones de educación básica y media; finalmente se hace referencia a la mejora realizada a la plataforma para integrarla al Sistema Académico de la Institución, de tal manera que se logró agilizar el proceso de solicitud y creación de los diversos cursos, motivando su uso por parte de los docentes.
Análisis del estado de cosas inconstitucionales en el sistema penitenciario y carcelario en Colombia
Authors: Huertas Díaz Omar , Manrique Molina Filiberto Eduardo R. , Benítez Núñez Christian 
Published: November 2023

Esta obra presenta una visión amplia y detallada, pero a la vez crítica y propositiva, sobre los retos que enfrenta el Estado colombiano ante la crisis humanitaria de sus centros carcelarios y penitenciarios. También destaca los esfuerzos de la Corte Constitucional para enfrentar ciertos problemas estructurales que han causado graves violaciones a los derechos fundamentales de miles de personas privadas de su libertad. Los textos aquí reunidos, escritos por diversos juristas latinoamericanos, proponen un viraje hacia un modelo integral de organización política, social y jurídica; resaltan las obligaciones de todo el sistema de Estado; promueven la construcción de una política criminal de corte humanitario y garantista. De este modo, se ofrece una herramienta útil para la implementación de un modelo que disminuya las conductas criminales, que no impacte de forma negativa las condiciones de reclusión, y que reduzca el hacinamiento carcelario
Pengembangan Strategi Branding, Pemasaran Online, Dan Peningkatan Kualitas Laporan Keuangan Pada Usaha Catering Dapoer Adiba
Authors: Ermawati Nanik Ermawati , Hidayanti Alfiyani Nur , Salisa Naila Rizki 
Published: November 2023

<p>Dampak pandemi Covid-19 terhadap perekonomian sangatlah besar termasuk diantaranya pada usaha bisnis catering. Permintaan jasa catering yang menurun mengharuskan pelaku usaha untuk dapat memutar otak agar bisnis yang dijalankan dapat tetap bertahan pada masa pandemi Covid-19 seperti saat ini. Pemasaran secara online lebih prospektif karena memungkinkan para calon pelanggan dan pengguna jasa catering memperoleh informasi lebih cepat mengenai produk dan jasa yang diberikan. Selain pemasaran secara online, strategi branding juga sangat diperlukan para pelaku UMKM. Strategi branding dan pemasaran online memudahkan para pelaku UMKM sekaligus konsumen dalam melakukan penjualan online. Tujuan dari pengabdian ini adalah memberikan pendampingan pelatihan pemasaran online dan juga cara melakukan strategi branding pada usaha catering Dapoer Adiba yang terletak di Kota Jepara. Selain itu pelaku usaha juga diberikan keterampilan membuat laporan keuangan berbasis sistem sederhana dengan menggunakan Microsoft Excel agar keuangan usaha dapat terkontrol secara sistematis dan terpercaya. Setelah melakukan pengabdian ini diharapkan pelaku usaha catering Dapoer Adiba dapat tetap meningkatkan penjualan dan semakin maju dalam menjalankan usaha bisnisnya.<strong> </strong></p>
Three clusters of grammatical abilities in individuals with language deficits “split” the universal grammar hypothesis
Authors: Vyshedskiy Andrey , Venkatesh Rohan , Khokhlovich Edward 
Published: November 2023

Abstract
In this study we assessed 15 language comprehension abilities in 55,558 individuals with language deficits 4 to 22 years of age using parent-generated reports. Data-driven cluster analysis identified three distinct clusters of co-expressed abilities. The first cluster, termed “command language,” included knowing the name, responding to ‘No’ or ‘Stop’, responding to praise, and following simple commands. The second cluster, termed “modifier language,” included understanding color and size modifiers, several modifiers in a sentence, size superlatives, and numbers. The third cluster, termed the “prepositional language,” included understanding of spatial prepositions, verb tenses, flexible syntax, possessive pronouns, explanations about people and situations, simple stories, and elaborate fairy tales. Independently, we performed data-driven cluster analysis of participants. 19.8% of participants were limited to command language phenotype; 58% of participants were limited to modifier language phenotype; 22.2% of participants were clustered to the most-advanced prepositional phenotype. All neurotypical participants were clustered to the prepositional phenotype. While the Universal Grammar hypothesis attempts to preach a dichotomy between the presence of grammatical abilities in humans and their absence in animals, this study shows that there are additional distinct language comprehension phenotypes that require an explanation.
ZNF276 and WIZ are CRBN neosubstrates involved in the anti-angiogenic activity of thalidomide and immunomodulatory drugs
Authors: Ito Takumi , Asatsuma-Okumura Tomoko , Endo Akinori , Yamamoto Junichi , Iwai Yoshiko , Yamaguchi Yuki , Naito Mikihiko , Handa Hiroshi , Saeki Yasushi 
Published: November 2023

Abstract
Thalidomide was once developed as a sedative but had been withdrawn from the market in the 1960s because of its serious teratogenicity. Currently, this drug is reevaluated and used for the treatment of multiple myeloma, and many derivatives such as lenalidomide and pomalidomide have been developed. CRBN is a primary target of thalidomide and its derivatives and forms an E3 ubiquitin ligase complex with DDB1 and CUL4. Although the basic mechanism of action of thalidomide is quite well understood, a long-standing question remains regarding its inhibitory effect on angiogenesis. Here, we employed a comprehensive proteomic approach using thalidomide-treated endothelial cells to identify ZNF276 and WIZ as CRBN neosubstrates. Thalidomide and its derivatives exert their anti-angiogenic effects through these two zinc finger proteins, resulting in the downregulation of FABP4. This study reveals the CRBN neosubstrates involved in thalidomide-induced anti-angiogenesis and provides attractive therapeutic targets of CRBN-based protein degraders.
Antifungal Susceptibility of Pathogenic Moulds isolated from patients at Tertiary Hospital in South western Uganda
Authors: Bazira Joel , Nalumaga Pauline , Tuhamize Barbra , Orishaba Francis , Frederickson Wasswa , Taseera Kabanda 
Published: November 2023

Abstract
Fungal infections are common in tropical regions causing diverse human infections. Their isolation and sensitivity testing plays a major key role in the clinical management. Samples from eye clinic, skin scrapings and nail clippings were obtained and stained with potassium hydroxide, observed at 40x objective lens for hyphae identification. They were inoculated onto potato dextrose agar slant and incubated for 14 days for mould isolation. Lactophenol cotton blue stain was used for macroscopic identification of Moulds. 3 antifungal powder agents were dissolved in RPMI-1640 solution for the MIC of the isolated Moulds. Of 40 Moulds isolated 30(75%) were skin scrapings, 5(12.5%) were corneal scrapings and 5(12.5) were nail scrapings. Of these isolates; 10 Aspergillus niger, 6 Penicillium, 5 Trichophyton mentagrophytes, 4 Curvularia, 5 Rhizopus, 4 Fusarium, 1 Bipolaris and fusarium, 1 Lasidiopolidia, 1 Collectrium, 2 Aspergillus fumigatus, 1 Aspergillus flavus. For MIC, Itraconazole had 39 sensitive and 1 resistant, Fluconazole had 35 sensitive and 5 resistant while Amphotericin B had 32 sensitive and 8 resistant isolates. Amphotericin B increased resistance is attributed to readily available polyene creams in the drug shops across Uganda.
ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression sponging miR-338-3p
Authors: Wang Shouhua , Zhu Xiang , Hao Yuan , Su Tingting , Shi Weibin 
Published: November 2023

Abstract
Circular RNAs (circRNAs) have recently been found as potential functional modulators of the cellular physiology processes in gastric cancer (GC). However, the potential clinical significance and molecular mechanisms of circRNAs involved in the development of GC remain largely unknown. In the study, we demonstrated that circFOXP1 was highly expressed in GC tissues compared with adjacent normal tissues. Higher circFOXP1 expression positively associated with tumor size, lymph node metastasis, TNM stage and poor prognosis in patients with GC. Multivariate Cox analysis revealed that higher circFOXP1 expression was an independent risk for the disease-free survival (DFS) and overall survival (OS) of GC patients. Functional studies showed that higher circFOXP1 expression promoted cell proliferation, cell invasion, and cell cycle progression in GC in vitro. In vivo, knockdown of circFOXP1 inhibited tumor growth. Mechanistically, by double luciferase reporter, Methylated RNA immunoprecipitation (MeRIP), RNA binding protein immunoprecipitation assay and RNA pull-down assays, we clarified that circFOXP1 was under m6A-modification mediated by ALKBH5 in GC cells. Besides, circFOXP1 promoted GC progression by regulating SOX4 expression sponging miR-338-3p in GC cells. In conclusion, our findings highlight that circFOXP1 could serve as a novel diagnostic and prognostic biomarker and potential therapeutic target of GC treatment.
Identification of key immune genes of endometriosis based on bioinformatics and machine learning
Authors: Yuan Ruiying , Gao Fumin , Li Xiaolong , Ou Xianghong 
Published: November 2023

Abstract

Introduction:
Immunity and inflammation are involved in a multitude of reproductive metabolic processes, with a particular focus on endometriosis (EMT). The aim of this study is to employ bioinformatics methods to explore novel immune-related biomarkers and assess their predictive capabilities for EMT.
Methods
mRNA expression profiles were obtained from the GSE141549 and GSE7305 datasets in the Gene Expression Omnibus (GEO) database, while immune-related genes were sourced from the ImmPort database. Immune genes associated with EMT were filtered for differential analysis. Interrelationships between different immune-related genes (DIRGs) were characterized using protein-protein interaction (PPI) networks. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were applied to the functionality of DIRGs. Least Absolute Shrinkage and Selection Operation (LASSO) regression models and Boruta models were built to determine candidate genes for EMT, and the performance of the prediction models and candidate genes were verified using Receiver Operator Characterization curve (ROC) in GSE141549 and GSE7305. Finally, we structured the EMT prediction normogram on the basis of the five candidate DIRGs. Expression of the five candidate DIRGs in human samples was examined using PCR and Western Blot. The relative proportions of 22 immune cells were computed using the CIBERSORT algorithm, and the correlations between immune cells and candidate DIRGs were emphasized.
Results
Altogether 769 differentially expressed genes (DEGs) and 94 DIRGs were detected between ectopic and normal endometrium. These DIRGs were mainly concentrated in positive regulation of response to external stimulus, collagen-containing extracellular matrix, receptor ligand activity and signaling receptor activator activity. KEGG enrichment analysis mainly addressed Cytokine-cytokine receptor interaction and Neuroactive ligand-receptor interaction. Then, five key genes (SCG2, FOS, DES, GREM1, and PLA2G2A) were characterized using the GSE141549 dataset and used to build a prediction model for EMT.
Conclusions
Immunity and inflammation have a major role in the elaboration of EMT. SCG2, FOS, DES, GREM1 and PLA2G2A can serve as important biomarkers for EMT.
Chinese Public's Discourse and Emotional Responses Regarding Japan's Nuclear Wastewater Discharge on Social Media: A Content Analysis of Sina Weibo Data
Authors: Zhu Bingke , Su Ran , Hu Xinqi , Lin Hongwei , Chen Jingxin , Li Qifeng , Wang Xingyu 
Published: November 2023

Abstract
Background: The global discourse surrounding the Japanese government's decision to discharge nuclear wastewater from the Fukushima Daiichi nuclear power plant into the ocean has attracted substantial international attention and fervent debates, notably across various social media platforms. This study aims to systematically investigate and analyze the subjects of discourse as well as the emotional inclinations expressed by the public prior to and subsequent to Japan's official declaration regarding the release of nuclear wastewater into the ocean (spanning from April 1, 2021 to May 30, 2021).
Methods: Employing a Python-based web crawler, we extracted a database comprising 139364 Sina Weibo microblogs from April 2021 to May 2021 pertained to the incident of Japanese nuclear wastewater discharge. This study demonstrates how to combine human and natural language processing (NLP) machine analysis, using TF-IDF (Term Frequency-Inverse Document Frequency) improved latent Dirichlet assignment (LDA) topic modeling and dictionary-based unsupervised learning to analyze seven segmented emotions of netizens at different stages of public opinion development.
Results: Based on the public opinion life cycle theory, we find that the dynamics of netizens' public opinion about Japan's discharge of nuclear wastewater are divided into three stages: incubation period, outbreak period and recession period. The NLP method discovered six topic trend: political statement, government accusations/netizens discussions, nuclear pollution and environmental hazards, netizens expression of dissatisfaction, appeal for science popularization, netizens outcry over the drinkability of nuclear wastewater. The sentimental analysis revealed a notable prevalence of negative emotions among individuals in relation to the incident, with negativity constituting 65% and positivity representing 35% of the emotional spectrum. Subsequent to an emotional categorization, it was discerned that the sentiment of "Disappointed" exhibited the highest proportion.
Conclusion: This study conclusively demonstrates that the approach we use here is capable of effectively reducing large amounts of community feedback (e.g., blog posts, social media data) through NLP and ensuring contextualization and rich human interpretation. Further, detecting and assessing the interests and concerns of social media users in real time can help relevant administrative agencies adapt to genuine public concerns and enable timely response, guidance and oversight.
Analysis of natural variation of the stress-responsive gene OsSUI1 in rice
Authors: Xu Na , Qiu Mudan , Cao Dan , Yu Dong , Li Yixing , Li Li , Song Shufeng , Yuan Zheming 
Published: November 2023

Abstract
Rice is subjected to various abiotic environmental stress throughout its lifetime and it has formed a complex regulatory network that balances growth and development with stress response. A stress-responsive gene, OsSUI1, was previously mined from microarray data, and transgenic studies revealed that overexpression of this gene caused abnormal floral organ development. However, the role of the OsSUI1 gene in stress response and how it is regulated is unclear. In this study, we obtained the ossui1 mutant by gene editing, and it exhibited high sensitivity to cold, heat and salt treatments compared to wild-type plants. RNA-seq analysis revealed that many transcription factors related to abiotic stress showed significant changes of expression in the ossui1, indicating a critical function of OsSUI1 in the response to abiotic stresses. Through polymorphic analysis, we found that the OsSUI1 gene in some japonica rice encodes a truncated protein product due to a single base deletion in the coding region compared to the sequence in indica rice. The promoter of OsSUI1 exhibited considerable similarity in japonica rice, whereas those of indica rice displayed polymorphism, a 4542-bp transposable element insertion in some indica varieties, which did not, however, impact the expression of OsSUI1. The YFP-tagged OsSUI1 protein found in indica accumulated in the nucleus, whereas the truncated protein in japonica indicated signals in both the cytoplasm and the nucleus. As an abiotic stress response gene, OsSUI1 has potential applications in rice breeding.
Study on the coupling characteristics of laser-TIG hybrid heat source with different offsets
Authors: Liu Liming , Yang Huanyu , Tao Xingkong , Cheng Zhigang 
Published: November 2023

Abstract

Based on the defects such as sidewall and interlayer unfusion in the welding process of titanium alloy thick plate, it is proposed to transverse offset between laser and arc to change the arc discharge position and energy distribution, which provides a theoretical basis for solving the welding defects of titanium alloy thick plate. In this study, the effect of transverse offset distance between laser and arc (TODLA) on the discharge characteristics of hybrid heat source coupling and the flow characteristics of molten pool was studied by using the welding method of plate surfacing. The dynamic behavior of the arc plasma, the molten pool and the keyhole was monitored in real time, and the plasma spectral information was collected to analyze its energy distribution characteristics. The results show that under different TODLA conditions, the charged plasma of the hybrid heat source has two different states: strong coupling state and separation state. When TODLA = 2 mm, the plasma at the center of the keyhole has the strongest spectral intensity, the lowest electron temperature and the highest electron density, which are 15174, 9546 K and 1.88×1017/cm3, respectively. At this time, the weld pool and keyhole have the maximum arc pressure and Marangoni force, resulting in an increase in the flow velocity of the weld pool and an increase in the area of the weld pool.
Chimerization of the Anti-Viral CD8+ T Cell Response with A Broad Anti-Tumor T Cell Response Reverses Inhibition of Checkpoint Blockade Therapy by Oncolytic Virotherapy
Authors: Vile Richard , Webb Mason , Vloten Jacob van , Evgin Laura , Sangsuwannukul Thanich , Kendall Benjamin , Tonne Jason , Thompson Jill , Metko Muriel , Moore Madelyn , Yerovi Maria Chiriboga , McNiven Mark , Monga Satdarshan , Borad Mitesh , Roberts Lewis 
Published: November 2023

Abstract

Although immune checkpoint inhibition (ICI) has produced profound survival benefits in a broad variety of tumors, a proportion of patients do not respond. Treatment failure is in part due to immune suppressive tumor microenvironments (TME), which is particularly true of hepatocellular carcinoma (HCC). Since oncolytic viruses (OV) can generate a highly immune-infiltrated, inflammatory TME, we developed a vesicular stomatitis virus expressing interferon-ß (VSV-IFNß) as a viro-immunotherapy against HCC. Since HCC standard of care atezolizumab/bevacizumab incorporates ICI, we tested the hypothesis that pro-inflammatory VSV-IFNß would recruit, prime, and activate anti-tumor T cells, whose activity anti-PD-L1 ICI would potentiate. However, in a partially anti-PD-L1-responsive model of HCC, addition of VSV-IFNß abolished anti-PD-L1 therapy. Cytometry by Time of Flight showed that VSV-IFNß expanded dominant anti-viral effector CD8 T cells with concomitant, relative disappearance of anti-tumor T cell populations which are the target of anti-PD-L1. However, by expressing a range of HCC tumor antigens within VSV, the potent anti-viral response became amalgamated with an anti-tumor T cell response generating highly significant cures compared to anti-PD-L1 ICI alone. Our data provide a cautionary message for the use of highly immunogenic viruses as tumor-specific immune-therapeutics by showing that dominant anti-viral T cell responses can inhibit sub-dominant anti-tumor T cell responses. However, by chimerizing anti-viral and anti-tumor T cell responses through encoding tumor antigens within the virus, oncolytic virotherapy can be purposed for very effective immune driven tumor clearance and can generate anti-tumor T cell populations upon which immune checkpoint blockade can effectively work.
Cross-Correlation Using a Complex Aperiodic FBG: A New Technique for Gas Detection
Authors: Rahme Matthew , Tuthill Peter , Betters Christopher , Large Maryanne , Leon-Saval Sergio 
Published: November 2023

Abstract

Optical cross-correlation is a technique that can achieve both high specificity and high sensitivity when deployed as the basis for a sensing technology. Offering significant gains in cost, size and complexity, it can also deliver significantly higher signal-to-noise ratios than traditional approaches such as absorption methodologies. In this paper, we present an optical cross-correlation technology constructed around a bespoke customised Fiber Bragg Grating (FBG). Exploiting the remarkable flexibility in design enabled by multiple aperiodic Bragg gratings, optical filters are devised that exactly mimic the absorption features of a target gas species (for this paper, acetylene C2H2) over some waveband of interest. This grating forms the heart of the sensor architecture described here that employs modulated optical cross-correlation for gas detection. An experimental demonstration of this approach is presented, and shown to be capable of differentiating between different concentrations of the C2H2 target gas.Furthermore these measurements are shown to be robust against interloper species, with minimal impact on the detection signal-to-noise arising from the introduction of contaminant gases. This represents is a significant step toward the use of customised FBGs as low-cost, compact, and highly customisable photonic devices for deployment in gas detection.
The mediating role of social connectedness in the relationship between smartphone use and psychological adjustment problems in Turkish youth
Authors: Yildirim Murat , Gecer Ekmel , Bagci Hakkı 
Published: November 2023

Abstract
This study investigated the mediating role of social connectedness in the relationship between excessive smartphone use and psychological adjustment problems. 484 young adults (M = 27.04 ± 4.36 years and 72.1% females) participated in this study. Using an online survey, participants completed the Multidimensional Smartphone Use Scale, Social Connectedness Scale-Revised, and Brief Psychological Adjustment-6. The results showed that smartphone use had a significant predictive effect on social connectedness and psychological adjustment problems. Social connectedness had also a significant predictive impact on psychological adjustment problems. Further, social connectedness partially mediated the relationship between smartphone use and psychological adjustment problems. The findings are fruitful in terms of presenting evidence for tailoring prevention and intervention programs to mitigate the adverse consequences of smartphone use on psychological health.