bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel fluorescent sensors based on 8-aminoquinoline receptor
Authors:   , Vongnam Kunnigar 
Published: November 2023

Two series of amidoquinoline-based fluorescent sensors are designed and synthesized for the selective detection of glucosamine and zinc ion in aqueous media. For the glucosamine sensors, three amidoquinoline-naphthalimide dyads are designed and synthesized in 67–73% overall yields in 3 steps from commercially available starting materials. Compounds with unsubstituted and nitro-naphthalimide show excellent selective ﬂuorescent responses towards glucosamine with the enhancement of ﬂuorescence quantum yields by 14 folds. The determination of HOMO-LUMO levels by linear sweep voltammetry suggests that the sensing mechanism likely involves the inhibition of photo-induced electron transfer (PET) between the aminoquinoline and naphthalimide moieties by glucosamine. The association constants of 1.55x104 and 1.45x104 M-1, along with the glucosamine detection limits of 1.06 and 0.29 µM are determined for unsubstituted and nitro-naphthalimide, respectively. The application of the nitro-naphthalimide derivative as a ﬂuorescent probe for real-time detection of cellular glucosamine at micromolar level in living Caco-2 cells is also demonstrated.

For the zinc ion sensors, four derivatives of 8-amidoquinolines have been successfully synthesized by extension of the p-conjugated system on the quinoline ring and incorporation of either the salicylaldimine or its reduced amino form. All four compounds show selective fluorescence enhancement by zinc (II) ion, attributing to chelation-enhanced fluorescence (CHEF) effects, in which the deprotonation of the amido –NH and phenolic -OH causes the internal charge transfer (ICT) process and results in the bathochromic shift of the emission spectra. The fluorescent signals of the four compound are observed at different wavelengths in the range of 320 to 390 nm depending on the p-conjugated systems. The sensing mechanism is verified by 1H-NMR titration, Mass Spectrometry, and the X-ray crystal structure of the sensor with salicylaldimine and unsubstituted aminoquinoline, which suggests a 1:1 binding stoichiometry between this fluorophore and zinc ion. The detection limits of 0.024 to 0.431 µM and the association constants ranging from 7.0x 103 to 1.2x 104 M-1 are estimated for the four sensors.
Pembinaan Literasi Anak berbasis Masjid di Desa Buntu Batu
Authors: Yamin Muh. 
Published: November 2023

Rendahnya tingkat literasi masyarakat indonesia harus menjadi perhatian khusus semua pihak dimana penguatan literasi harus dilakukan sedini mungkin terutama pada anak-anak yang merupakan calon penerus bangsa. Pengabdian ini dilakukan menggunakan pendekatan Asset Based Comunity Development (ABCD). Metode ABCD merupakan metode yang bertujuan untuk memanfaatkan kekuatan yang ada dalam masyarakat sebagai sarana pengembangan berkelanjutan yang memuat proses untuk melihat potensi apa saja yang dimiliki masyarakat. Pengabdian ini dilaksanakan di Desa Buntu Batu Kecematan Basse sangtempe Kabupaten Luwu. Tujuan dari kegiatan pegabdian ini adalah untuk meningkatkan gairah literasi anak. Secara garis besar ada tiga agenda utama dalam kegiatan pengabdian ini yakni pojok baca, diskusi ceria dan menulis sekitar.
Perencanaan Desain Bangunan Masjid As-Sholihin Desa Tumada Kecamatan Kapontori Kabupaten Buton
Authors: Asrasal Aswad , Abdu Muhammad , Musrifin  , Rumbayan Hendra Kundrad Susanto , Hafsyah Intan Ahlul 
Published: November 2023

Masjid merupakan tempat suci bagi umat islam yang digunakan sebagai tempat peribadatan kepada Allah Subhanahu wa ta’ala. Seiring dengan bertambahnya jumah penduduk, kebutuhan untuk tempat ibadah yang aman, nyaman dan indah merupakan hal yang penting bagi penduduk di daerah tersebut khususnya yang beragama islam. Program pengabdian masyarakat khususnya pada bidang teknik sipil merupakan bentuk inplementasi ilmu pengetahuan dan teknologi langsung kepada masyarakat dalam upaya mempercepat dan meningkatkan kualitas pembangunan yang ada di daerah. Untuk mencapai hal tersebut, digunakan konsep desain yang baik dan metode pendampingan layanan jasa konsultasi desain pada pemerintah desa dan masyarakat agar tujuan program ini bisa tepat guna sesuai yang direncanakan. Hasil akhir yang didapatkan adalah adanya Detail Engineering Design (DED) dan Rencana Angaran Biaya (RAB) yang siap digunakan pada pembangunan Masjid As sholihin Desa Tumada Kecamatan Kapontori Kabupaten Buton.
Snacks em barra à base de batata doce, com alegação de propriedades nutricionais: desenvolvimento, caracterização nutricional e sensorial
Authors: De Oliveira Silva Yago , Maria da Silva Araújo Ídila , Dos Santos Dantas Beatriz , Lavínia Barros Carneiro Karla , Dos Santos Garruti Deborah , Maria Leal de Medeiros Márcia 
Published: November 2023

A demanda por alimentos com alegações nutricionais tem aumentado ultimamente, sendo as barras de cereais produtos que vêm ganhando espaço no mercado. A batata-doce (Ipomoea batatas Lam) é um alimento de alto valor energético, fonte de carboidrato, considerada uma excelente opção de alimento para praticantes de exercício físico. Neste trabalho, objetivou-se desenvolver e caracterizar nutricionalmente e sensorialmente snacks em barra à base de batata-doce. As batatas-doces (var. Jerimum e var. Real) e os snacks (SB Jerimum e SB Real) foram avaliados quanto à sua composição centesimal, teores de fibra dietética total – FDT, fibra solúvel – FDS, fibra insolúvel – FDI e carotenoides totais; textura instrumental e análise sensorial (aceitação global e dos atributos aparência, cor, sabor e textura; diagnóstico dos atributos sabor de batata-doce, gosto doce, crocância, firmeza, suculência e adesividade; e intenção de compra) . As batatas-doces Jerimum e Real diferiram entre si quanto à composição nutricional, com destaque para a var. Jerimum que apresentou maiores teores de FDT (3,21%), FDS (1,50%) e carotenoides (13,95 mg.100-1), o que também refletiu em maiores concentrações desses nutrientes no snacks SB Jerimum. No entanto, o teor de proteínas (6,13%) e FDI (31%) foram maiores na SB Real. A faixa de aceitação sensorial para os atributos foi de “gostei pouco” na escala hedônica. As batatas-doces das variedades Jerimum e Real são ótimas opções de matéria-prima para desenvolvimento de produtos com alegação nutricional, com rico teor de carotenoides, fibras dietéticas e atrativa aceitabilidade sensorial.
Annealing effect on morphology, surface roughness and structure of thermally evaporated tin oxide thin films
Authors: Ibiyemi Abideen A. , Ilyas M. A. , Lawal Jamiu 
Published: November 2023

SnO2 thin films were produced utilizing the Thermal Vacuum Evaporation method on quartz substrates. Three samples—FAA, FV-200, and FA-400—were made and labelled. While samples of the FV-200 and FA-400 were annealed at 200 ◦C and 400 ◦C, respectively, the as deposited thin film is FAA. The root mean square (RMS) roughness, uniformity, and average roughness of the films were all measured using the atomic force microscope. The film was spherical after being annealed at 400 ◦C, covering the substrate more uniformly with erratic growth. The as-deposited film exhibits an uneven distribution of grains of varying sizes. The sample showed consistent grain development after being annealed at 200 ◦C. The root mean square values of samples FAA, FV-200, and FA400 are 42.2 nm, 41.7 nm, and 112.7 nm. The XRD technique was used to the strongest of which could be seen at 2θ = 300, or the (200) plane of Sn metal. The thin film was annealed in vacuum at 200 ◦C and revealed three more peaks, with the strongest peak appearing at 2θ = 30◦, which is consistent with an enhanced structure of Sn metal thin film. The sample annealed at 400 ◦C revealed high surface roughness compare to other samples and its films are clearly defined, spherical, and cover the substrate more evenly. Whereas, a mixture of large and small grains with uneven distribution throughout the substrate and poor film homogeneity was reveal by film without heat treatment.
جماعة الإخوان المسلمين والأنظمة الحاكمة في مصر (1952م-2011م)
Authors: م.م أسامه فائق عبد الرسول المظفر  
Published: November 2023

تُعدّ حركة جماعة الإخوان المسلمين ( النشأة، الاهداف، الايديولوجيا) ،وعلاقتها والأنظمة الحاكمة ومدى تأثيرها في القرات السياسية وشكل النظام القائم، مرت جماعة الإخوان المسلمين منذ نشأتها بصراع طويل مع النظام السياسي المصري، اذ يمكن القول ان العلاقة بين جماعة الإخوان المسلمين والنظام الحاكم في مصر في المدة (1952م_2011 م) كانت معقدة ومتوترة، إذ تغيرت الأنظمة الحاكمة وتعاملت مع جماعة الإخوان المسلمين بأساليب متنوعة على الرغم من تقديم الجماعة تحديات سياسية وفكرية للأنظمة الحاكمة، إلا إنها تعرضت للاضطهاد والقمع بسبب إدراك خطورة الحركة وتأثيرها على النظام السياسي، كونها تحظى بشعبية كبيرة وذلك بفضل برامجها الاجتماعية والخيرية التي تم تقديمها إلى فئات من أبناء الشعب المصري، ومن هنا جاء تأثير الجماعة الكبير على الناخبين وقدرتها على تجنيد الانصار لدعم اجندتها السياسية، وعلى الرغم من الأثر الذي حققته الجماعة لاسيما في عهد الرئيس الأسبق محمد حسني مبارك (1981م–2011م)، كما انها تمكنت من الدخول إلى البرلمان رغم عدم حصولها على الشرعية، فمرة تدخل ضمن تحالفات وأخرى تدخل أعضائها ضمن المرشحين المستقلين، فضلًا عن تمكنها بالفوز في النقابات، لكن هذا الأثر كان مقيدًا ومحدودًا.
THE EFFECT OF PROMOTION, PRICE AND SERVICE ON CUSTOMER SATISFACTION AT DE SALFA BAROKAH CAKE SHOP IN MARISA DISTRICT, POHUWATO REGENCY
Authors: Afiyati Lely 
Published: November 2023

Abstract
The aims of this study were: To determine the effect of Promotion (X1), Price (X2) and Service (X3) both simultaneously and partially on Customer Satisfaction (Y) at the De Salfa Barokah Cake Shop in Marisa District, Pohuwato Regency. is multiple analysis techniques. The F test result is 8,589, so the effect of promotion, price, and service quality simultaneously or jointly has a positive effect on customer satisfaction. Promotion T-test results are 0.024, so the influence of Partial or Individual Promotion marketing strategies has a positive effect on customer satisfaction. The result of the price T-test is 0.444, so the effect of Partial or Individual Price has a positive effect on customer satisfaction. The results of the T-test of service quality are 0.260, so the influence of service quality in Partial or Individual has a positive effect on customer satisfaction. Based on the results of the analysis of the independent variables, namely promotion, price, and quality of service that affect customer satisfaction at the Kue De salfa Barokah shop, Marisa District, Pohuwato Regency using multiple regression analysis, it is proven that the promotion, price, and service quality variables together have a positive effect on satisfaction. Customer. With this, the cake shop De Salfa Barokah, if you want to increase sales volume, all these variables can be taken into consideration together.

Keyword: Promotion, Price, Pelayanan, Service, and Satisfaction
Late Adverse Events After Chimeric Antigen Receptor T-Cell Therapy for Patients With Aggressive B-Cell Non-Hodgkin Lymphoma
Authors: Camacho-Arteaga Lina , Iacoboni Gloria , Kwon Mi , Bailén Rebeca , Hernani Rafael , Benzaquén Ana , López-Corral Lucía , Pérez-López Estefania , Leguízamo-Martínez Lina María , Calvo-Orteu Maria , Guerreiro Manuel , Balaguer-Rosello Aitana , Alonso-Martínez Carla , Vidal Xavier , Barba Pere , Agustí Antònia 
Published: February 2025

ImportanceAcute adverse events (AEs) after chimeric antigen receptor (CAR) T-cell infusion are well documented, but less information is available regarding the long-term toxic effects.ObjectiveTo assess the occurrence of late AEs for adult patients with large B-cell lymphoma (LBCL) treated with commercially available CD19-targeted CAR T cells.Design, Setting, and ParticipantsA prospective, observational, clinical practice cohort study was conducted from September 1, 2018, to December 31, 2022, among 172 adult patients in 6 Spanish hospitals who received CD19-targeted CAR T-cell therapy for relapsed or refractory LBCL and survived at least 3 months after infusion, without subsequent antilymphoma therapy.ExposureTreatment with tisagenlecleucel or axicabtagene ciloleucel.Main Outcomes and MeasuresData on any late AEs occurring in this patient population were collected until the patients received new antilymphoma therapy, were lost to follow-up, died, or reached 24 months after infusion, whichever occurred first. Data collection for each patient started at the third month after infusion and included new-onset AEs, as well as persistent AEs that started earlier but were still ongoing at that time point.ResultsThe study enrolled 172 patients (mean [SD] age, 58.5 [13.7] years; 101 men [58.7%]), of whom 135 (78.5%) experienced at least 1 late AE of any grade. Infections were the late AEs with the highest incidence (5.6 per 100 person-months [95% CI, 4.5-7.0 per 100 person-months]), followed by neutropenia (3.6 per 100 person-months [95% CI, 2.9-4.5 per 100 person-months]) and thrombocytopenia (2.2 per 100 person-months [95% CI, 1.7-3.0 per 100 person-months]). The incidence of infectious episodes remained stable during the whole study period, while cytopenias decreased beyond 6 months after infusion. All cases of nonrelapse-related mortality were due to infections (COVID-19 pneumonia in 3 patients and sepsis or bacterial pneumonia in 4 patients). Twenty-three patients (13.4%) experienced 27 dermatologic AEs, all mild, with most of them (88.9% [24 of 27]) starting beyond 3 months after infusion. Fifteen neurologic AEs were reported in 15 patients (8.7%), and 10 patients (5.8%) developed 13 cardiovascular AEs. Five secondary neoplasms were reported in 4 patients (2.3%), with no cases of T-cell malignant neoplasms.Conclusions and RelevanceThis cohort study suggests that CAR T-cell therapy has a favorable safety profile. However, continuous follow-up of patients is needed, as serious AEs can occur years after infusion.
Single‐Atom Enables Reverse Hydrogen Spillover for High‐Performance Protonic Ceramic Fuel Cells
Authors: Zhao Sunce , Ma Wenjia , He Beibei , Ling Yihan , Huang Yonglong , Hu Feng , Shu Zhu , Zhao Ling 
Published: February 2025

AbstractProtonic ceramic fuel cells (PCFCs) offer a promising avenue for sustainable energy conversion, however, their commercial potential is hindered by sluggish proton‐involved oxygen reduction reaction (P‐ORR) kinetics and inadequate durability of cathode materials. Here, a novel single‐atom Ru anchor on BaCe0.125Fe0.875O3−δ (BCF) perovskite, synthesized by a facile and scalable solid‐state approach, as a potential cathode for PCFCs is reported. Theoretical and experimental analyses demonstrate that the single‐atom Ru on BCF, characterized by a unique 4‐coordinate Ru‐O‐Fe configuration, not only induces reverse hydrogen spillover but also acts as an active site for P‐ORR. The application of the optimized 2Ru‐BCF (2 wt.% Ru) cathode in a single cell delivers an exceptional peak power density of 1.78 W cm−2 at 700 °C, along with excellent operational stability over 200 h. These findings provide new insights into single‐atom engineering, advancing the commercial viability of PCFCs.
Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population
Authors: Chen Banru , Guan Lizhi , Wu Chao , Gong Yiwen , Wu Lei , Zhang Minchun , Cao Zhiwen , Chen Yufei , Yang Chengcan , Wang Bing , Li Yunqi , Li Bin , Bi Yufang , Ning Guang , Wang Jiqiu , Wang Weiqing , Liu Ruixin 
Published: February 2025

AbstractGut microbiota is essential for the function of peripherally‐induced regulatory T (pTreg) cells. However, how commensal bacteria affect thymically derived fat‐resident Treg cells that harbor a unique expression of peroxisome proliferator‐activated receptor (PPAR)‐γ and suppress inflammation in visceral adipose tissue (VAT), is not well defined. Here it is revealed that microbiota depletion causes a drastic decline in Treg cell population in VAT, particularly those expressing ST2 (ST2+ Treg), which are largely restored after gut microbiome reconstruction. Mechanistically, gut microbiota‐derived butyrate increases VAT ST2+ Treg cells through binding PPARγ. Butyrate supplementation and high fiber diet increase VAT ST2+ Treg population in obese mice, and ameliorated glucose tolerance and visceral inflammation. Furthermore, human omental adipose Treg cells show positive correlation with fecal butyrate and certain butyrate‐producing microbes. This study identifies the critical role of gut microbiota‐butyrate‐PPARγ axis in maintaining VAT Treg population, pinpointing a potential approach to augment VAT Treg population and ameliorate inflammation.
The Impact of Regulatory Focus on the Inaction Inertia Effect
Authors: Liu Hsin‐Hsien , Chou Hsuan‐Yi 
Published: February 2025

ABSTRACTInaction inertia reduces the likelihood of consumers accepting an opportunity after previously missing a more favorable one. This study explores how consumers' regulatory focus influences the inaction inertia effect. The authors propose that because promotion‐ (vs. prevention‐) focused individuals tend to process information at a high construal level, they are more likely to decouple the previous and current opportunities due to distal psychological distance, reducing perceived regret, and inaction inertia. Promotion‐ (vs. prevention‐) focused individuals are more likely to experience higher processing fluency when encountering the current opportunity due to regulatory fit, which forms more positive overall feelings and reduces the inaction inertia effect. Results from one pilot study and three formal experiments show that people with a promotion (vs. prevention) focus are subject to lower inaction inertia. Moreover, perceived fluency and overall feelings play a more important and robust sequential mediating role than perceived coupling and regret. The current research findings address important gaps in the literature on inaction inertia and regulatory focus, providing valuable insights for practitioners in designing advertising and marketing strategies to mitigate the inaction inertia effect.
Causeway Coast, Northern Ireland: Developing a Geohazard Citizen Observatory to Assist Risk Management
Authors: Parker Kieran , Lemon Kirstin , Gomes Rui Carrilho 
Published: February 2025

Abstract
The Causeway Coast is located on the northern coast of Northern Ireland. A rugged coastline, it is a area of high tourism due to its natural beauty and an area of significance in Irish mythology. Two sites on the Causeway Coast were chosen to develop a geohazard citizen pilot observatory, the world-renowned Giants Causeway and Carrick-a-rede. Both sites attract a high number for visitors throughout the year and both are also managed by the National Trust. The Causeway Coast is geologically dominated by Paleogene mafic volcanics and is highly susceptible to frequent landslide occurrences. It is also an area with a high number of international, European and national designations due to its geological importance and biodiversity. The objective of the pilot was to (i) carry out routine monitoring of the sites, (ii) engage local communities and stakeholders to provide them with education awareness of geohazards, (iii) encourage their active participation in hazard monitoring through a mobile application developed by the AGEO project, (iv) evaluate satellite data from the Copernicus programme as a geohazard monitoring tool and (v) promote better understanding of geohazard risk to stakeholders to enhance risk management at the sites using evidence based information. To meet these objectives, we initiated research and monitoring to better understand and characterise the risk through carrying out geological site surveys, analysis of available datasets, completing Laser imaging, Detection And Ranging (LiDAR) and photogrammetry surveys, assessed satellite derived data and incorporation of citizen monitoring data. The pilot also initiated a series of outreach events within the local communities to raise awareness of geohazard and the participatory role citizens could take in monitoring their landscape. The work carried out resulted in the recording of numerous landslide events including images of each event leading to an increased understanding of the areas and exposure of risk across the sites. A common reference dataset of the geomorphology, to millimetre scale, was attained providing a future reference for change detection analysis. Citizen involvement was also achieved through local engagement and collection and evaluation of citizen data as a means of geohazard monitoring to enhance risk management of the sites.
The Complex Problem of Teacher Shortage in Germany—Some Ideas About the Role of Success and Failure in Teacher Education, Educational Planning and Second Career Teachers
Authors: Radisch Falk 
Published: February 2025

Abstract
The Problem of teacher shortage is actual one of the most discussed problems in the school system in Germany as well as in other countries. This paper gives an insight into some specific points and reasons that may be important for the search for solutions. It could be shown, that teacher shortage is a generic but differentiated problem for different regions, school types and subjects. It could be also shown, that teacher shortage is likely underestimated in Germany, reasoned in challenges of educational forecasting, especially by the actual way of forecasting the number of successful graduations from teacher education. The analyses of data from Mecklenburg-West Pomerania indicate that the drop-out of student teachers is higher than expected and student teachers graduate mostly later than scheduled. Last but not least it could be shown, that the traditional system of teacher education might not be able to close the gap alone—especially in a short term. Reforming and developing the traditional system of teacher education is necessary, but it is difficult and will need a very long time. For that (and other reasons), it requires a stable and flexible system of alternative paths to becoming a teacher.
The Academic Training of Second Career Teachers in Saxony: Programs and Implications for the Professionalization of Lateral Entrants
Authors: Bárány Thomas , Hoischen Julian 
Published: February 2025

Abstract
Over the past decade, the shortage of teachers in Germany has steadily worsened. This article focuses on lateral entry into the teaching profession in the Federal State of Saxony, using the example of TU Dresden. First of all, it will explain how lateral entry is structured in Saxony from a legal perspective, and how academic education is implemented as a central qualification element for the professionalization of lateral entrants using the example of the BQL project at TU Dresden. Subsequently, findings from the ZLSB’s accompanying research on the program will be presented and discussed. For this purpose, 705 written interviews at the beginning and 204 at the end of the lateral entry program were evaluated. The focus is on the conditions for success and occupation-specific professionalization characteristics of the lateral entry program; in particular, self-assessments and job-related beliefs as well as motivations for career choice are examined. In order to identify possible differences and similarities with undergraduate students studying to become teachers, the results will be compared with findings from the accompanying research on regular teacher education programs at TU Dresden. In the case of lateral entrants, there is a very high degree of similarity to the results for students studying to become teachers. Only in a few aspects of the surveys are there findings that show, for example, that career choices are more autonomous, and that decisions and perceptions of the teaching profession are less influenced by external factors among career changers.