bluuebunny/crossref_metadata_2025_split huggingface dataset:
MENINGKATKAN MINAT BELAJAR DENGAN MENGGUNAKAN MEDIA WORDWALL KELAS 4 DI SEKOLAH DASAR
Authors: Setyorini Diyah , Suneki Sri , Prayitno Muhammad , Prasetiawati Catur 
Published: January 2024

Tujuan penelitian membangun minat belajar pada anak di sekolah dasar dengan berbasis teknologi yaitu Wordwall, di zaman sekarang hampir menyeluruh anak di sekolah dasar suka bermain game online di handphone/ gadget, untuk itu metode ini bisa diterapkan kepada anak di Sekolah dasar guna mengalihkan kebiasaan anak agar tidak kecanduan game online dan membuat daya minat belajar lebih baik. faktor mendasar yang mempengaruhi daya minat belajar anak menjadi rendah yaitu Teknik pengajaran yang membosankan. Wali kelas disana hanya mengguakan Youtube, PPT dalam mengajar. Setelah diterapkan Media Wordwall pada anak tingkatan sekolah dasar terutama di SDN Panggung lor kelas IV untuk meningkatkan daya minat belajar di sekolah menjadi tinggi. Secara tidak langsung WordWall juga bisa digunakan untuk menilai pengetahuan selain belajar siswa juga dapat bermain game online seperti WordWall. Peneliti menggunakan metode kualitatif melalui observasi terhadap wali kelas IV SDN Pannggung Lor dan memberikan angket kepada siswa untuk mengetahui minat belajar siswa melalui media WOrdWall. Hasil dari penelitian ini dengan menggunakan media pembelajaran berbasis game onlain edukatif dapat meningkatkan minat belajar siswa.
Kata Kunci: Minat Belajar1; WordWall2; Game Online3
تاثير التدريب على وفق مبدأ القصور الذاتي في تطوير بعض المتغيرات البايوميكانيكية بأداء الرفسة الامامية لدى للاعبي الكاراتية باعمار 13-16 سنة.
Authors: Teacher. Dr.. Fouad Nouri Saeed  
Published: January 2024

تكمن أهمية هذه الدراسة كونها سوف تلقي الضوء على الدمج مابين التدريب ومبدأ القصور الذاتي عند تطوير أداء مهارات الرفس بالكاراتية فضلا عن الأهمية التطبيقية من خلال اعداد تمريات خاصة باستخدام وسيلة زيادة كتلة الجسم أو الأداء للقسم السفلى من الجسم ومعرفة تاثيرها في تطوير القدرة والسرعة من ناحية ميكانيكية وهدف البحث اعداد تمرينات خاصة على وفق مبدأ القصور الذاتي ( زيادة الكتلة ) لتطوير بعض المتغيرات البايوميكانيكية الأنفجارية والسرعة في أداء الرفسة الامامية لدى لاعبي الكاراتية و التعرف على تاثير التدريبات الخاصة على وفق مبدأ القصور الذاتي ( زيادة الكتلة ) في بعض المتغيرات البايوميكانيكية في أداء الرفسة الامامية لدى لاعبي الكاراتية و التعرف على الفروق بين الاختبارات القبلية والبعدية للمجموعة التجريبية في بعض المتغيرات البايوميكانيكية لأداء الرفسة الامامية لدى لاعبي الكاراتية . استخدم الباحث المنهج التجريبي بتصميم المجموعة الواحدة وذلك لملائمتة لطبيعة المشكلة البحث و اختار الباحث مجتمع البحث من لاعبي الكاراتية في مركز التدريبي سروَري التابع لمنظمة تنمية الكاراتية ، وتم اختيارعينة البحث البالغ ( 5 ) لاعبين بالطريقة العشوائية و قام الباحث باجراء الأختبار القبلي لمهارة الرفسة الامامية ( ماي كيري ) لعينة البحث البالغ عددهم (5) خمسة لاعبين حيث قام الباحث بأعداد تدريبات خاصة على وفق أحد متغيرات القصور الذاتي( زيادة الكتلة ) وتم تطبيق الوحدات التدريبية لمدة (8) أسابيع وبمعدل (3) وحدة تدريبية في الأسبوع وبواقع(24)وحدة تدريبية وأستخدام الباحث الوسائل الإحصائية من خلال الحقيبة الإحصائية (SPSS) لأستخراج النتائج عن طريق :الوسط الحسابي ، معامل الالتواء ،الانحراف المعياري ، قيمة (ت) لعينات المتناظر.
أثر جدولة التمرين العشوائي المتغير والعشوائي الثابت في تعلم فن الاداء المهاري لمهارتي الضرب الساحق وحائط الصد بالكرة الطائرة
Authors: Qutaiba Suwayd Jassim  , Assis prof.Dr. Murad Ahmed Yas  
Published: January 2024

هدف البحث التعرف على اثر جدولة التمرين العشوائي المتغير والعشوائي الثابت في تعلم فن الاداء المهاري لمهارتي الضرب الساحق وحائط الصد بالكرة الطائرة ، واستعمل الباحثان المنهج التجريبي بتصميم المجموعتين المتكافئتين ذات الاختبار القبلي والبعدي، وتـــم تـــحــــديـــد مـــجـــتــــمـــع الـــبـــحــــث مـــن طـــلاب الــــمــــرحــــلـــة الثانية في كلية التربية البدنية وعلوم الرياضة في جامعة كركوك للعام الدراسي (2022-2023) للدراسة الصباحية والـــبــــالــــغ عـــددهـــم (87) طــــالــــب مــــوزعــــيـــــن عــــلـــى شــــعـــــبــــتــــيــــن (أ) بعدد (43) طالب وشعبة (ب) بـــــعــــــدد (44) طــــالــــب حـــيــــث تـــم اخــــــتـــــيــــار (10) طـــــلاب مـــــن كــــل شــــعــــبـــة بـــطــــريــــقـــــة عــــشـــوائـــيـــة ليكون عينة البحث الرئيسة (20) طالب موزعين على مجموعتين (10 ) طلاب للمجموعة التجريبية الأولــــى و (10 ) طـــــلاب لـــلـــمـــجـــمـــوعـــة التجريبية الثانية من مجتمع البحث الــــكـــــلــــي، وتــــم اخـــــتــــيـــار (20) طــــلاب مـــــن مــــجــــتــــمـــع الــــبـــحـــث ليمثلوا عينة التجربة الاستطلاعية وتم استبعادهم من العينة الرئيسة ، ومن اجل ضبط موصفات العينة تم اجراء عملية التجانس والتكافؤ بـــيـــن مـــجــــمـــوعـــتـــي الـــبـــحـــث الـــتـــجــــريــبـــيـــة في مهارتي الضرب الساحق وحائط الصد ،ومن ثم تطـبيق التـجربة الرئـيسية والمتضمنة وحــدات تعليـمية ثم اجراء الاختبارات البعدية ومن بعد جمع البيانات تم اجراء العمليات الاحصائية المناسبة الخاصة بالاختبارات من اجـل الوصـول الـى النتائج، واستخلص الباحثـان الى ان تنـفـيذ التمرين العشوائي المتغير والعشوائي الثابت كان له تأثير في تعلم مهارتي الضرب الساحق وحائط الصد لطلاب المرحلة الثانية وساهم بشكل واضح في تعلم فن الاداء المهاري للطالب .
Pengaruh Pendidikan Kesehatan Tentang Manajemen Diri Terhadap Tingkat Kepatuhan Pasien Diabetes Mellitus Di Kabupaten Semarang
Authors: Sonhaji Sonhaji , Hani Umi , Rahmani Rina 
Published: January 2024

Latar Belakang : Pengendalian faktor resiko dibutuhkan untuk mencegah diabetes mellitus dan menurunkan tingkat fatalitas. Kendala utama pada penanganan penyakit DM adalah kejenuhan pasien dalam mengikuti terapi yang sangat diperlukan untuk mencapai keberhasilan. Pendidikan kesehatan diperlukan karena penyakit DM adalah penyakit yang berhubungan dengan gaya hidup sehingga perlu peningkatan pengetahuan untuk merubah gaya hidup. Tujuan : mengetahui pengaruh pendidikan kesehatan tentang manajemen diri terhadap tingkat kepatuhan pasien diabetes melitus. Metode : metode penelitian quasi experimental dan desain penelitian one group pre-test and post-test. Sampel dalam penelitian ini sebanyak 40 responden yang dipilih menggunakan teknik Purposive sampling. Instrumen yang digunakan dalam penelitian ini yaitu kuesioner SDSCA (The Summary of Diabates Self-Care Activities) dengan 24 item pernyataan. Uji yang digunakan yaitu uji t berpasangan. Hasil penelitian : menunjukkan pengaruh tingkat kepatuhan sebelum dan sesudah pendidikan kesehatan (p = <0.001; α = 5%). Nilia mean tingkat kepatuhan responden sebelum diberikan pendidikan kesehatan adalah 67.40 dan setelah diberikan pendidikan kesehatan adalah 93.40. Hasil penelitian menunjukkan adanya pengaruh pendidikan kesehatan tentang manajemen diri terhadap tingkat kepatuhan pasien diabetes melitus. Hasil penelitian ini diharapkan pendidikan kesehatan dapat diberikan secara berkelanjutan dalam meningkatkan kepatuhan terhadap manajemen diri pada pasien Diabetes Melitus di tingkat pelayanan kesehatan dan terus memberikan motivasi kepada klien diabetes melitus supaya terus mengikuli pola hidup yang sehat.
Two-dimensional segmentation fusion tool: an extensible, free-to-use, user-friendly tool for combining different bidimensional segmentations
Authors: Piccinini Filippo , Drudi Lorenzo , Pyun Jae-Chul , Lee Misu , Kwak Bongseop , Ku Bosung , Carbonaro Antonella , Martinelli Giovanni , Castellani Gastone 
Published: January 2024

Introduction: In several fields, the process of fusing multiple two-dimensional (2D) closed lines is an important step. For instance, this is fundamental in histology and oncology in general. The treatment of a tumor consists of numerous steps and activities. Among them, segmenting the cancer area, that is, the correct identification of its spatial location by the segmentation technique, is one of the most important and at the same time complex and delicate steps. The difficulty in deriving reliable segmentations stems from the lack of a standard for identifying the edges and surrounding tissues of the tumor area. For this reason, the entire process is affected by considerable subjectivity. Given a tumor image, different practitioners can associate different segmentations with it, and the diagnoses produced may differ. Moreover, experimental data show that the analysis of the same area by the same physician at two separate timepoints may result in different lines being produced. Accordingly, it is challenging to establish which contour line is the ground truth.Methods: Starting from multiple segmentations related to the same tumor, statistical metrics and computational procedures could be exploited to combine them for determining the most reliable contour line. In particular, numerous algorithms have been developed over time for this procedure, but none of them is validated yet. Accordingly, in this field, there is no ground truth, and research is still active.Results: In this work, we developed the Two-Dimensional Segmentation Fusion Tool (TDSFT), a user-friendly tool distributed as a free-to-use standalone application for MAC, Linux, and Windows, which offers a simple and extensible interface where numerous algorithms are proposed to “compute the mean” (i.e., the process to fuse, combine, and “average”) multiple 2D lines.Conclusions: The TDSFT can support medical specialists, but it can also be used in other fields where it is required to combine 2D close lines. In addition, the TDSFT is designed to be easily extended with new algorithms thanks to a dedicated graphical interface for configuring new parameters. The TDSFT can be downloaded from the following link: https://sourceforge.net/p/tdsft.
Climate smart agriculture? Adaptation strategies of traditional agriculture to climate change in sub-Saharan Africa
Authors: Okoronkwo David John , Ozioko Remigius Ikechukwu , Ugwoke Rachael Ujunwa , Nwagbo Uzoh Victor , Nwobodo Cynthia , Ugwu Chidiebere Happiness , Okoro Gozie Godswill , Mbah Esther C. 
Published: January 2024

IntroductionSub-Saharan Africa faces increasingly unpredictable and extreme weather patterns due to climate change, posing significant threats to food security and rural livelihoods. Traditional agriculture, deeply rooted in the region's history and culture, is particularly vulnerable to these changes. This study investigates the adaptation strategies of traditional agricultural farmers to climate change using southeast Nigeria as a microcosm of the broader challenges facing sub-Saharan Africa.MethodsMultistage sampling procedure was used to select 75 farmer group leaders in the study region. Cross-sectional data were collected through semi-structured interview schedules and focus group discussions. Data were analyzed using descriptive statistics and principal component analysis using Varimax rotated matrix.ResultsFindings showed that farmers rely on face-to-face discussions with neighbors (76.0%), fellow farmers (66.7%), and radio (54.7%) as their primary sources of information on climate change. Results showed that traditional adaptation practices such as use of organic manure (x¯ = 3.89), traditional organic composting (x¯ = 3.80), afforestation (x¯ = 3.71), agroforestry (x¯ = 3.61) were the topmost traditional agricultural practices use to cushion the effect of climate change. Conserving the overall soil health, soil moisture retention, reducing CO2 emissions and maintaining crop productivity were the major reasons for using the traditional approaches. Climate-induced drought and high cost of accessing weather information (x¯ = 1.93), and inadequate funding (x¯ = 1.92), among others were the key constraints to adaptation.DiscussionResults showed that farmers prioritize agronomic manipulation and integrated research approaches as key strategies to adapting traditional agriculture to climate anomalies. Although farmers used their indigenous practices, continuous learning and improvement through capacity-building workshops and progress monitoring are essential for effective climate change adaptation. Policymakers should invest in promoting indigenous knowledge, provide access to credit for climate-resilient infrastructure, promote climate-smart agricultural practices and foster collaborative research as the cornerstone for sustainable rural development.
Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts
Authors: Cui Shujun , Zhang Ze , Rodrigue Denis , Béland François , Rouabhia Mahmoud 
Published: January 2024

This study aimed to design a THC-rich hydrogel to deliver cannabis derivatives topically. We developed hydrogels using polyvinyl alcohol (PVA) mixed with propylene glycol (PG), vegetable glycerin (VG), or both to facilitate the dissolution of delta-9-tetrahydrocannabinol (THC). The hydrogels showed a brown color, confirming the presence of the cannabinoid. They exhibit a porous structure and better mechanical properties than PVA alone. Indeed, the hydrogel containing PG, VG, or both showed elastic deformation behaviors with lower water content. FTIR analysis demonstrated the presence of THC with two specific peaks at 1,575 and 1,619 cm−1, confirming the presence of THC in the hydrogels. Human dermal fibroblast cultures onto the surface of all hydrogels confirmed the safety of the THC-rich hydrogel as the cell adhesion was comparable to the control (no THC). Furthermore, cells adhering to the hydrogels could proliferate, showing increased cell viability at 48 and 72 h, with a higher proliferation obtained with the THC-rich PVA-PG-VG hydrogels. Such cell behavior could be due to the release of the THC in the culture medium, as demonstrated by ultra-high performance liquid chromatography (UPLC), showing the presence of THC in the culture medium, ranging from 203 to 290 μg after 24 h of incubation of the hydrogels containing PG and VG or both. In comparison, the released THC from the PVA hydrogel was higher, reaching 852 μg. It is interesting to note that the THC release at 24, 48, and 72 h was slower with the hydrogels containing PG, VG, and both, compared to PVA alone. Overall, the present study has designed safe THC-rich PVA-PG-VG hydrogels as a functional delivery system for the topical use of cannabinoids to control tissue diseases, such as inflammation.
Obesity- and lipid-related indices as a predictor of type 2 diabetes in a national cohort study
Authors: Wang Ying , Zhang Xiaoyun , Li Yuqing , Gui Jiaofeng , Mei Yujin , Yang Xue , Liu Haiyang , Guo Lei-lei , Li Jinlong , Lei Yunxiao , Li Xiaoping , Sun Lu , Yang Liu , Yuan Ting , Wang Congzhi , Zhang Dongmei , Li Jing , Liu Mingming , Hua Ying , Zhang Lin 
Published: January 2024

ObjectiveType 2 diabetes mellitus (T2DM) remains a major and widespread public health concern throughout the world. The prevalence of T2DM in the elderly has risen to the top of the list of public health concerns. In this study, obesity- and lipid-related indices were used to predict T2DM in middle-aged and elderly Chinese adults.MethodsThe data came from the China Health and Retirement Longitudinal Study (CHARLS), including 7902 middle-aged and elderly participants aged 45 years or above. The study assessed the association of obesity- and lipid-related indices and T2DM by measuring 13 indicators, including body mass index (BMI), waist circumference(WC), waist-height ratio (WHtR), conicity index(CI), visceral adiposity index (VAI), Chinese visceral adiposity index (CVAI), lipid accumulation product (LAP), a body shape index (ABSI), body roundness index (BRI), triglyceride glucose index (TyG-index) and its correlation index (TyG-BMI, TyG-WC, TyG-WHtR). The association of 13 obesity- and lipid-related indices with T2DM was investigated by binary logistic regression. Additionally, the predictive anthropometric index was evaluated, and the ideal cut-off value was established using the receiver operating characteristic (ROC) curve analysis and area under the curve (AUC).ResultsThe study included 7902 participants, of whom 3638(46.04) and 4264(53.96) were male and female. The prevalence of T2DM in mid-aged and old adults in China was 9.02% in males and 9.15% in females. All the above 13 indicators show a modest predictive power (AUC&gt;0.5), which was significant for predicting T2DM in adults (middle-aged and elderly people) in China (P&lt;0.05). The results revealed that TyG-WHtR [AUC =0.600, 95%CI: 0.566–0.634] in males and in females [AUC =0.664, 95%CI: 0.636–0.691] was the best predictor of T2DM (P&lt;0.05).ConclusionMost obesity- and lipid-related indices have important value in predicting T2DM. Our results can provide measures for the early identification of T2DM in mid-aged and elderly Chinese to reduce the prevalence of T2DM and improve health.
Gut microbiota and sepsis and sepsis-related death: a Mendelian randomization investigation
Authors: Shang Weifeng , Zhang Sheng , Qian Hang , Huang Sisi , Li Hui , Liu Jiao , Chen Dechang 
Published: January 2024

BackgroundIt is unclear what the causal relationship is between the gut microbiota and sepsis. Therefore, we employed Mendelian randomization (MR) to determine whether a causal link exists between the two.MethodsThis study used publicly available genome-wide association studies (GWAS) summary data of gut microbiota, sepsis, sepsis (critical care), and sepsis (28-day death in critical care) to perform a two-sample MR analysis. To ensure the robustness of the results, we also conducted a sensitivity analysis.ResultsFor sepsis susceptibility, inverse variance weighted (IVW) estimates revealed that Victivallales (OR = 0.86, 95% CI, 0.78–0.94, p = 0.0017) was protective against sepsis, while Lentisphaerae (OR = 0.89, 95% CI, 0.80–0.99), Gammaproteobacteria (OR = 1.37, 95% CI, 1.08–1.73), Clostridiaceae1 (OR = 1.21, 95% CI, 1.04–1.40), RuminococcaceaeUCG011 (OR = 1.10, 95% CI, 1.01–1.20), Dialister (OR = 0.85, 95% CI, 0.74–0.97), and Coprococcus2 (OR = 0.81, 95% CI, 0.69–0.94) presented a suggestive association with the development of sepsis (all p &lt; 0.05). For sepsis (critical care), IVW estimates indicated that Lentisphaerae (OR = 0.70, 95% CI, 0.53–0.93), Victivallales (OR = 0.67, 95% CI, 0.50–0.91), Anaerostipes (OR = 0.49, 95% CI, 0.31–0.76), LachnospiraceaeUCG004 (OR = 0.51, 95% CI, 0.34–0.77), and Coprococcus1 (OR = 0.66, 95% CI, 0.44–0.99) showed a suggestive negative correlation with sepsis (critical care) (all p &lt; 0.05). For sepsis (28-day death in critical care), IVW estimates suggested that four bacterial taxa had a normally significant negative correlation with the risk of sepsis-related death, including Victivallales (OR = 0.54, 95% CI, 0.30–0.95), Coprococcus2 (OR = 0.34, 95% CI, 0.14–0.83), Ruminiclostridium6 (OR = 0.43, 95% CI, 0.22–0.83), and Coprococcus1 (OR = 0.45, 95% CI, 0.21–0.97), while two bacterial taxa were normally significantly positively linked to the risk of sepsis-related death, namely, Mollicutes (OR = 2.03, 95% CI, 1.01–4.08) and Bacteroidales (OR = 2.65, 95% CI, 1.18–5.96) (all p &lt; 0.05). The robustness of the above correlations was verified by additional sensitivity analyses.ConclusionThis MR research found that several gut microbiota taxa were causally linked to the risk of sepsis, sepsis in critical care, and sepsis-related 28-day mortality in critical care.
Exploring the causal relationship between inflammatory cytokines and immunoinflammatory dermatoses: a Mendelian randomization study
Authors: Li Jiaxuan , Lu Yining , Zhao Xuelian 
Published: January 2024

ObjectivesPrevious studies have shown that the onset and progression of several immunoinflammatory dermatoses are closely related to specific immune-inflammatory responses. To further assess the causal relationship between 41 inflammatory cytokines and immunoinflammatory dermatoses, we used a Mendelian randomization method.MethodsMendelian two-sample randomization utilized inflammatory cytokines from a GWAS abstract containing 8,293 healthy participants as well as psoriasis (4,510 cases and 212,242 controls), atopic dermatitis (7,024 cases and 198,740 controls), and vitiligo (131 cases and 207,482 controls). The causal relationship between exposure and outcome was explored primarily using inverse variance weighting. In addition, multiple sensitivity analyses, including MR-Egger, weighted median, simple model, weighted model, and MR-PRESSO, were simultaneously applied to enhance the final results.ResultsThe results showed that in clinical practice, IL-4 and IL-1RA were suggestive indicators of atopic dermatitis risk (OR = 0.878, 95% CI = 0.78–0.99, p = 0.036; OR = 0.902, 95% CI = 0.82–1.00, p = 0.045). SCGF-b was a suggestive indicator of psoriasis risk (OR = 1.095, 95% CI = 1.01–1.18, p = 0.023). IL-4 is a suggestive indicator of vitiligo risk (OR = 2.948, 95% CI = 1.28–6.79, p = 0.011).ConclusionOur findings suggest that circulating inflammatory cytokines may play a crucial role in the pathogenesis of chronic skin inflammation. IL-4 and IL-1RA may have inhibitory roles in the risk of developing atopic dermatitis, while SCGF-b may have a promoting role in the risk of developing psoriasis. Furthermore, IL-4 may contribute to the risk of developing vitiligo. These results provide insights into further understanding the mechanisms of chronic skin inflammation and offer new targets and strategies for the prevention and treatment of related diseases.
Dynamics of Whole Transcriptome Analysis (WTA) and Surface markers expression (AbSeq) in Immune Cells of COVID-19 Patients and Recovered captured through Single Cell Genomics
Authors: Soni Jyoti , Chattopadhyay Partha , Mehta Priyanka , Mohite Ramakant , Tardalkar Kishore , Joshi Meghnad , Pandey Rajesh 
Published: January 2024

IntroductionSingle-cell multi-omics studies, such as multidimensional transcriptomics (whole transcriptomic analysis, WTA), and surface marker analysis (antibody sequencing, AbSeq), have turned out to be valuable techniques that offer inaccessible possibilities for single-cell profiling of mRNA, lncRNA, and proteins.MethodsWe used this technique to understand the dynamics of mRNA and protein-level differences in healthy, COVID-19-infected and recovered individuals using peripheral blood mononuclear cells (PBMCs). Our results demonstrate that compared to mRNA expression, protein abundance is a better indicator of the disease state.ResultsWe demonstrate that compared to mRNA expression, protein abundance is a better indicator of the disease state. We observed high levels of cell identity and regulatory markers, CD3E, CD4, CD8A, CD5, CD7, GITR, and KLRB1 in healthy individuals, whereas markers related to cell activation, CD38, CD28, CD69, CD62L, CD14, and CD16 elevated in the SARS-CoV-2 infected patients at both WTA and AbSeq levels. Curiously, in recovered individuals, there was a high expression of cytokine and chemokine receptors (CCR5, CCR7, CCR4, CXCR3, and PTGRD2). We also observed variations in the expression of markers within cell populations under different states.DiscussionFurthermore, our study emphasizes the significance of employing an oligo-based method (AbSeq) that can help in diagnosis, prognosis, and protection from disease/s by identifying cell surface markers that are unique to different cell types or states. It also allows simultaneous study of a vast array of markers, surpassing the constraints of techniques like FACS to query the vast repertoire of proteins.