bluuebunny/crossref_metadata_2025_split huggingface dataset:
All Inorganic Sb3+–Ln3+‐Codoped Cs2NaYCl6 for Highly Efficient Single‐Source White‐Light Emission and Ratiometric Optical Thermometer Applications
Authors: Guo Xiu‐Xian , Wei Jun‐Hua , Luo Jian‐Bin , He Zi‐Lin , Zhang Zhi‐Zhong , Chen Jing‐Hua , Kuang Dai‐Bin 
Published: October 2023

AbstractSingle‐source white‐light emitters are highlighted with stable color and excellent color rendering ability, which can largely simplify the white‐light‐emitting‐diode (WLED) structure. All‐inorganic and lead‐free double perovskites have attracted extensive research interest and provide versatile doping sites to accommodate the extrinsic multi‐valent ions. Herein, the synthesis and tunable emission of Sb3+–Ln3+‐codoped Cs2NaYCl6 single crystals (SCs) is reported. Particularly, bright white‐light emission with a high photoluminescence quantum yield of 80.5% is yielded in 0.5%Sb3+–2%Tb3+–2%Sm3+‐codoped Cs2NaYCl6 SCs. Steady‐state photoluminescence (PL) and time‐resolved PL spectra are employed to reveal the energy transfer from Sb3+‐induced self‐trapped excitons to Ln3+ ions. Temperature‐dependent PL spectra further demonstrate that the fluorescence intensity ratio of band 657 to band 590 nm is highly dependent on the temperature, and the relative sensitivity reaches a maximum of up to 1.59% K−1 at 260 K. Moreover, the WLED based on 0.5%Sb3+‐2%Tb3+‐2%Sm3+‐codoped Cs2NaYCl6 SCs delivers a higher average color rendering index of 87 than 0.5%Sb3+‐0.8%Tb3+‐2.5%Ho3+‐codoped Cs2NaYCl6 (74.6). The outstanding white‐light‐emission performance together with the high temperature dependence of the fluorescence spectra confers Sb3+–Ln3+‐codoped Cs2NaYCl6 with huge application potential in solid‐state lighting and ratiometric optical thermometry.
Mammary Microvessels are Sensitive to Menstrual Cycle Sex Hormones
Authors: Moccia Carmen , Cherubini Marta , Fortea Marina , Akinbote Akinola , Padmanaban Prasanna , Beltran‐Sastre Violeta , Haase Kristina 
Published: October 2023

AbstractThe mammary gland is a highly vascularized organ influenced by sex hormones including estrogen (E2) and progesterone (P4). Beyond whole‐organism studies in rodents or cell monocultures, hormonal effects on the breast microvasculature remain largely understudied. Recent methods to generate 3D microvessels on‐chip have enabled direct observation of complex vascular processes; however, these models often use non‐tissue‐specific cell types, such as human umbilical vein endothelial cells (HUVECs) and fibroblasts from various sources. Here, novel mammary‐specific microvessels are generated by coculturing primary breast endothelial cells and fibroblasts under optimized culture conditions. These microvessels are mechanosensitive (to interstitial flow) and require endothelial–stromal interactions to develop fully perfusable vessels. These mammary‐specific microvessels are also responsive to exogenous stimulation by sex hormones. When treated with combined E2 and P4, corresponding to the four phases of the menstrual cycle (period, follicular, ovular, and luteal), vascular remodeling and barrier function are altered in a phase‐dependent manner. The presence of high E2 (ovulation) promotes vascular growth and remodeling, corresponding to high depletion of proangiogenic factors, whereas high P4 concentrations (luteal) promote vascular regression. The effects of combined E2 and P4 hormones are not only dose‐dependent but also tissue‐specific, as are shown by similarly treating non‐tissue‐specific HUVEC microvessels.
Design and Characterization of Model Systems that Promote and Disrupt Transparency of Vertebrate Crystallins In Vitro
Authors: Bergman Michael R. , Hernandez Sophia A. , Deffler Caitlin , Yeo Jingjie , Deravi Leila F. 
Published: October 2023

AbstractPositioned within the eye, the lens supports vision by transmitting and focusing light onto the retina. As an adaptive glassy material, the lens is constituted primarily by densely‐packed, polydisperse crystallin proteins that organize to resist aggregation and crystallization at high volume fractions, yet the details of how crystallins coordinate with one another to template and maintain this transparent microstructure remain unclear. The role of individual crystallin subtypes (α, β, and γ) and paired subtype compositions, including how they experience and resist crowding‐induced turbidity in solution, is explored using combinations of spectrophotometry, hard‐sphere simulations, and surface pressure measurements. After assaying crystallin combinations, β‐crystallins emerged as a principal component in all mixtures that enabled dense fluid‐like packing and short‐range order necessary for transparency. These findings helped inform the design of lens‐like hydrogel systems, which are used to monitor and manipulate the loss of transparency under different crowding conditions. When taken together, the findings illustrate the design and characterization of adaptive materials made from lens proteins that can be used to better understand mechanisms regulating transparency.
Nanomedicine for Diagnosis and Treatment of Atherosclerosis
Authors: Cheng Jingyun , Huang Hui , Chen Yu , Wu Rong 
Published: October 2023

AbstractWith the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and the associated diseases have emerged as the leading cause of death. Due to their fascinating physical, chemical, and biological characteristics, nanomaterials are regarded as a promising tool to tackle enormous challenges in medicine. The emerging discipline of nanomedicine has filled a huge application gap in the atherosclerotic field, ushering a new generation of diagnosis and treatment strategies. Herein, based on the essential pathogenic contributors of atherogenesis, as well as the distinct composition/structural characteristics, synthesis strategies, and surface design of nanoplatforms, the three major application branches (nanodiagnosis, nanotherapy, and nanotheranostic) of nanomedicine in atherosclerosis are elaborated. Then, state‐of‐art studies containing a sequence of representative and significant achievements are summarized in detail with an emphasis on the intrinsic interaction/relationship between nanomedicines and atherosclerosis. Particularly, attention is paid to the biosafety of nanomedicines, which aims to pave the way for future clinical translation of this burgeoning field. Finally, this comprehensive review is concluded by proposing unresolved key scientific issues and sharing the vision and expectation for the future, fully elucidating the closed loop from atherogenesis to the application paradigm of nanomedicines for advancing the early achievement of clinical applications.
Nickel‐Regulated Composite Cathode with Balanced Triple Conductivity for Proton‐Conducting Solid Oxide Fuel Cells
Authors: Tong Hua , Hu Wenjing , Fu Min , Yang Chunli , Tao Zetian 
Published: October 2023

AbstractProton‐conducting solid oxide fuel cells (H‐SOFCs) have the potential to be a promising technology for energy conversion and storage. To achieve high chemical compatibility and catalytic activity, nickel‐doped barium ferrate with triple conducting ability is developed as cathodes for H‐SOFCs, presenting an impressive electrochemical performance at intermediate temperatures. The cell performance with the optimized BaCe0.26Ni0.1Fe0.64O3–δ (BCNF10) composite cathode reaches an outstanding performance of 1.04 W cm−2 at 600 °C. The high electrocatalytic capacity of the nickel‐doped barium ferrate cathode can be attributed to its significant proton conductivity which is confirmed through hydrogen permeation experiments. Density functional theory (DFT) calculations are further conducted to reveal that the presence of nickel can enhance processes of hydration formation and proton migration, leading to improve proton conductivity and electro‐catalytic activity.
Does increasing the availability of a nutritious food produced by a small‐ and medium‐sized enterprise increase its consumption? Evidence from a field experiment in Kenya
Authors: Maredia Mywish K. , Porter Maria , Nakasone Eduardo , Ortega David L. , Caputo Vincenzina 
Published: October 2023

AbstractMany development programs rely on the idea that increasing profitability of small‐ and medium‐sized enterprises (SMEs) could increase availability of nutritious foods among low‐income consumers. We designed a randomized controlled trial in which we made a specific nutritious product produced by an SME exhaustively available in low‐income local markets. We find that compared to control markets, consumers in treated markets purchased and consumed more of this product and less of competing brands with added sugar and fat. However, overall consumption for the product category was not increased and there was no change in the consumption of other related but potentially less nutritious foods. Our findings suggest the need for alternative policies to increase consumption of nutritious foods.
Gray matter and episodic memory associations with olfaction in middle‐aged to older adults
Authors: Eckert Mark A. , Benitez Andreana , Soler Zachary M. , Dubno Judy R. , Schlosser Rodney J. 
Published: October 2023

AbstractBackgroundAge‐related declines in olfaction contribute to low quality of life and appear to occur with declines in cognitive function, including diminished episodic memory. We tested the hypothesis that low gray matter volume within cortical regions that support olfaction and episodic memory can explain age‐related differences in olfactory and episodic memory functions.MethodsT1‐weighted images, Sniffin’ Sticks olfactory measures, and the NIH Toolbox‐Cognition Battery were administered to 131 middle‐aged to older adults (50–86 years; 66% female). Correlation was used to examine the associations between these measures. A network‐based image processing approach was then used to examine the degree to which spatial patterns of gray matter variance were related to the olfactory and cognitive measures. Structural equation modeling was used to characterize the relative specificity of olfactory, cognitive, gray matter, and aging associations.ResultsOlfactory threshold, discrimination, and identification exhibited small to medium effect size associations with episodic memory performance (rs = 0.27–0.42, ps < 0.002). Gray matter volume within medial temporal and orbitofrontal cortex was also related to olfactory (discrimination and identification) and episodic memory function (rs = 0.21–0.36, ps < 0.019). Age and episodic memory explained the same variance in olfaction that was explained by the medial temporal and orbitofrontal pattern of gray matter volume.ConclusionsThe results of this cross‐sectional study suggest that identifying mechanisms contributing to differences in medial temporal and orbitofrontal cortex will advance our understanding of co‐morbid olfactory and cognitive declines.
Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy
Authors: Kelly Louise , Brown Christopher , Michalik Daniel , Hawkes Cheryl A. , Aldea Roxana , Agarwal Nivedita , Salib Rami , Alzetani Aiman , Ethell Douglas W , Counts Scott E. , de Leon Mony , Fossati Silvia , Koronyo‐Hamaoui Maya , Piazza Fabrizio , Rich Steven A. , Wolters Frank J. , Snyder Heather , Ismail Ozama , Elahi Fanny , Proulx Steven T. , Verma Ajay , Wunderlich Hilary , Haack Mareike , Dodart Jean Cosme , Mazer Norman , Carare Roxana O. 
Published: October 2023

AbstractThis editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age‐related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid‐related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA‐related inflammation (CAA‐ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.
Boosting H+ Storage in Aqueous Zinc Ion Batteries via Integrating Redox‐Active Sites into Hydrogen‐Bonded Organic Frameworks with Strong π‐π Stacking
Authors: Chu Juan , Liu Zhaoli , Yu Jie , Cheng Linqi , Wang Heng‐Guo , Cui Fengchao , Zhu Guangshan 
Published: October 2023

AbstractIn the emerging aqueous zinc ion batteries (AZIBs), proton (H+) with the smallest molar mass and fast (de)coordination kinetics is considered as the most ideal charge carrier compared with Zn2+ counterpart, however, searching for new hosting materials for H+ storage is still at its infancy. Herein, redox‐active hydrogen‐bonded organic frameworks (HOFs) assembled from diaminotriazine moiety decorated hexaazatrinnphthalene (HOF‐HATN) are for the first time developed as the stable cathode hosting material for boosting H+ storage in AZIBs. The unique integration of hydrogen‐bonding networks and strong π‐π stacking endow it rapid Grotthuss proton conduction, stable supramolecular structure and inclined H+ storage. As a consequence, HOF‐HATN displays a high capacity (320 mAh g−1 at 0.05 A g−1) and robust cyclability of (>10000 cycles at 5 A g−1) based on three‐step cation coordination storage. These findings get insight into the proton transport and storage behavior in HOFs and provide the molecular engineering strategy for constructing well‐defined cathode hosting materials for rechargeable aqueous batteries.
Single‐Atom Heterogeneous Catalysts: Human‐ and AI‐Driven Platform for Augmented Designs, Analytics and Reality‐Enabled Manufacturing
Authors: Cheng Lei , Tang Yawen , Ostrikov Kostya (Ken) , Xiang Quanjun 
Published: October 2023

AbstractHeterogeneous catalysts with targeted functionality can be designed with atomic precision, but it is challenging to retain the structure and performance upon the scaled‐up manufacturing. Particularly challenging is to ensure the “atomic economy”, where every catalytic site is most gainfully utilized. Given the emerging synergistic integration of human‐ and artificial intelligence (AI)‐driven augmented designs (AD), augmented analytics (AA), and augmented reality manufacturing (AM) platforms, this minireview focuses on single‐atom heterogeneous catalysts (SAHCs) and examines the current status, challenges, and future perspectives of translating atomic‐level structural precision and data‐driven discovery to next‐generation industrial manufacturing. We critically examine the atomistic insights into structure‐driven SAHCs functionality and discuss the opportunities and challenges on the way towards the synergistic human‐AI collaborative data‐driven platform capable of monitoring, analyzing, manufacturing, and retaining the atomic‐scale structure and functions. Enhanced by the atomic‐level AD, AA, and AM, evolving from the current high‐throughput capabilities and digital materials manufacturing acceleration, this synergistic human‐AI platform is promising to enable atom‐efficient and atomically precise heterogeneous catalyst production.
Relationship between homework time and academic and non‐academic performance in China: A preliminary test of the nonlinear hypothesis
Authors: Shao Yueyang , Liu Hongyun , Zhao Pingping , Liu Qimeng , Liu Jian 
Published: October 2023

AbstractInspired by complex system theory, this study adopts a multilevel piecewise regression model to examine the relationship between homework time and the development of students in different grades using a large‐scale testing database in China. The results indicate that the relationship between homework time and students’ performance is positive when homework time is less than the cut‐off values and becomes negative when homework time is greater than the cut‐off values. For different dependent variables, the cut‐off values of homework time differ but are all within a range (1–1.2 h for grade 4 and 1.7–2 h for grade 8). The reasons for the difference in cut‐off values among students in different grades are discussed.
Rosmarinic acid enhances CHO cell productivity and proliferation through activation of the unfolded protein response and the mTOR pathway
Authors: Mao Leran , Schneider James W. , Robinson Anne S. 
Published: October 2023

AbstractRosmarinic acid (RA) has gained attraction in bioprocessing as a media supplement to improve cellular proliferation and protein production. Here, we observe up to a two‐fold increase in antibody production with RA‐supplementation, and a concentration‐dependent effect of RA on cell proliferation for fed‐batch Chinese hamster ovary (CHO) cell cultures. Contrary to previously reported antioxidant activity, RA increased the reactive oxygen species (ROS) levels, stimulated endoplasmic reticulum (ER) stress, activated the unfolded protein response (UPR), and elicited DNA damage. Despite such stressful events, RA appeared to maintained cell health via mammalian target of rapamycin (mTOR) pathway activation; both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) were stimulated in RA‐supplemented cultures. By reversing such mTOR pathway activity through either chemical inhibitor addition or siRNA knockdown of genes regulating the mTORC1 and mTORC2 complexes, antibody production, UPR signaling, and stress‐induced DNA damage were reduced. Further, the proliferative effect of RA appeared to be regulated selectively by mTORC2 activation and have reproduced this observation by using the mTORC2 stimulator SC‐79. Analogously, knockdown of mTORC2 strongly reduced X‐box binding protein 1 (XBP1) splicing, which would be expected to reduce antibody folding and secretion, sugging that reduced mTORC2 would correlate with reduced antibody levels. The crosstalk between mTOR activation and UPR upregulation may thus be related directly to the enhanced productivity. Our results show the importance of the mTOR and UPR pathways in increasing antibody productivity, and suggest that RA supplementation may obviate the need for labor‐intensive genetic engineering by directly activating pathways favorable to cell culture performance.
Hydrophobic ion pairing and microfluidic nanoprecipitation enable efficient nanoformulation of a small molecule indolamine 2, 3‐dioxygenase inhibitor immunotherapeutic
Authors: Badiee Parisa , Maritz Michelle F. , Dehghankelishadi Pouya , Dmochowska Nicole , Thierry Benjamin 
Published: October 2023

AbstractBlockade of programmed cell death‐1 (PD‐1) is a transformative immunotherapy. However, only a fraction of patients benefit, and there is a critical need for broad‐spectrum checkpoint inhibition approaches that both enhance the recruitment of cytotoxic immune cells in cold tumors and target resistance pathways. Indoleamine 2, 3‐dioxygenase (IDO) small molecule inhibitors are promising but suboptimal tumor bioavailability and dose‐limiting toxicity have limited therapeutic benefits in clinical trials. This study reports on a nanoformulation of the IDO inhibitor navoximod within polymeric nanoparticles prepared using a high‐throughput microfluidic mixing device. Hydrophobic ion pairing addresses the challenging physicochemical properties of navoximod, yielding remarkably high loading (>10%). The nanoformulation efficiently inhibits IDO and, in synergy with PD‐1 antibodies improves the anti‐cancer cytotoxicity of T‐cells, in vitro and in vivo. This study provides new insight into the IDO and PD‐1 inhibitors synergy and validates hydrophobic ion pairing as a simple and clinically scalable formulation approach.
Improving the techno‐functionality of air‐classified pea flour fine fraction by enzymatic proteolysis, followed by Maillard‐induced conjugation with available carbohydrates in the flour
Authors: Mookerjee Abhiroop , Nickerson Michael , Tanaka Takuji 
Published: October 2023

AbstractBackground and ObjectivesAir‐classified pea protein‐enriched flour (PPEF) was hydrolyzed with trypsin and papain and heat conjugated with the carbohydrate fraction of the flour via the Maillard reaction to form protein–carbohydrate conjugates. The surface and functional properties of the conjugates were assessed thereafter.FindingsThe surface charge of the conjugates (trypsin and papain conjugates) (−27.5 to −32.2 mV and −33.1 to −37.5 mV) was higher than that of PPEF (−24.2 ± 0.5 mV and −27.3 ± 1.1 mV) at pH 7 and 10. Low degrees of trypsin hydrolysis, followed by conjugation resulted in enhanced foam capacity (109.2% ± 2.0%), and heated trypsin controls had the highest foam stability (76.9%) at pH 4. The emulsion activity index of the hydrolyzed protein–carbohydrate conjugates (hydrolyzed proteins conjugated with starch) was higher at pH 4 (15.9–22.2 min) as compared to pH 7 (16.5–21.3 min). Trypsin conjugates showed the highest emulsion stability (ES) at pH 4 (96.4%–98%), whereas the ES at pH 7 and 10 was almost comparable. Both oil‐holding (OHC: 1.9–3.9 g/g) and water‐holding capacities (WHC: 1.7–2.4 g/g) were significantly improved.ConclusionsMaillard conjugated proteins have enhanced functional properties at pH 4, 7, and 10 as compared to PPEF. Most of the conjugates show high functionality at pH 4. It was also observed that only heating the low‐cost, raw materials produced conjugates with enhanced functional properties.Significance and NoveltyEnhanced functional properties at acidic pH are indicative of their use in beverage emulsions like fruit juices and processed drinks. High WHC and OHC show their potential use in the food industry as an alternative to animal proteins.
A many‐objective optimization‐based local tensor factorization model for skin cancer detection
Authors: Zhao Haochen , Wen Jie , Yang Jinqian , Cai Xingjuan , Liu Chunxia 
Published: October 2023

SummaryExploring the associations between microRNAs (miRNAs) and diseases can identify potential disease features. Prediction of miRNA‐skin cancer associations has become an effective method for detecting skin cancer, as direct detection of skin cancer is challenging. However, traditional binary associations prediction methods overlook high‐order feature differences of miRNAs in different types of skin cancer. Although current tensor decomposition methods have addressed this, they assume a consistent composition standard of global tensor elements, ignoring differences in the composition standards of local sub‐tensors. This leads to poor prediction accuracy and comprehensiveness and fails to consider the credibility and diversity requirements of patients and doctors in practical applications. In this paper, we represent miRNA‐skin cancer associations as a tensor and employ tensor decomposition for tensor completion to achieve prediction purposes. First, we propose a credibility evaluation indicator and introduce four objective functions: accuracy, comprehensiveness, credibility, and diversity, to construct a many‐objective local tensor factorization model (MOLTF). Then, to avoid wrong individuals when solving this model with genetic algorithms, we propose a corrected single‐point crossover operator and a corrected multi‐point mutation operator. On the miRNA‐disease dataset HMDD v3.2, our algorithm improves accuracy by 14.5% compared to the recent baseline, demonstrating its effectiveness.