bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoplasmic reticulum stress regulators exhibit different prognostic, therapeutic and immune landscapes in pancreatic adenocarcinoma
Authors: Liu Shanshan , He Kaini , Yang Longbao , Xu Fangshi , Cui Xiaoguang , Qu Li , Li Xueyi , Ren Bin‐cheng 
Published: February 2024

AbstractEndoplasmic reticulum stress (ERS) and unfolded protein response are the critical processes of tumour biology. However, the roles of ERS regulatory genes in pancreatic adenocarcinoma (PAAD) remain elusive. A novel ERS‐related risk signature was constructed using the Lasso regression analysis. Its prognostic value, immune effect, metabolic influence, mutational feature and therapeutic correlation were comprehensively analysed through multiple bioinformatic approaches. The biofunctions of KDELR3 and YWHAZ in pancreatic cancer (PC) cells were also investigated through colony formation, Transwell assays, flow cytometric detection and a xenograft model. The upstream miRNA regulatory mechanism of KDELR3 was predicted and validated. ERS risk score was identified as an independent prognostic factor and could improve traditional prognostic model. Meanwhile, it was closely associated with metabolic reprogramming and tumour immune. High ERS risk enhanced glycolysis process and nucleotide metabolism, but was unfavourable for anti‐tumour immune response. Moreover, ERS risk score could act as a potential biomarker for predicting the efficacy of ICBs. Overexpression of KDELR3 and YWHAZ stimulated the proliferation, migration and invasion of SW1990 and BxPC‐3 cells. Silencing KDELR3 suppressed tumour growth in a xenograft model. miR‐137 could weaken the malignant potentials of PC cells through inhibiting KDELR3 (5′‐AGCAAUAA‐3′). ERS risk score greatly contributed to PAAD clinical assessment. KDELR3 and YWHAZ possessed cancer‐promoting capacities, showing promise as a novel treatment target.
Does HPV biotype influence the characteristics and evolution of plantar warts?
Authors: García‐Oreja Sara , Álvaro‐Afonso Francisco Javier , Sevillano‐Fernández David , García‐Morales Esther Alicia , López‐Moral Mateo , Lázaro‐Martínez José Luis 
Published: February 2024

AbstractBackgroundFew studies have addressed the relationship of human papillomavirus (HPV) biotypes to patient characteristics and the clinical signs, course, and response to the treatment of plantar warts.ObjectiveAnalyze the HPV types associated with plantar warts and their relationship with warts characteristics, patient characteristics and response to treatment.MethodsA total of 372 patients sampled for hyperkeratosis of a plantar wart were included. Multiplex polymerase chain reaction (PCR) was performed to detect the HPV biotype.ResultsThe prevalence of HPV was 81.2%, and HPV1 was the most prevalent biotype (36.1%). HPV1 was the most prevalent biotype in patients < 70 years old (90.9% in < 10 years), and biotypes 2, 19 and 27 were the most prevalent in patients > 70 years old (p = 0.012). HPV1 was the most frequent in patients with one (39,9%) or two (47.1%) warts and HPV5 (33.3%) in patients with three warts (p < 0.001). Cure, spontaneous resolution, and recurrence were higher in HPV1 (p < 0.001). HPV14 warts healed the fastest (2 months quartile 1–3 (2.0–2.0)), and HPV5 (10.977 (6.0–20.0)) and HPV27 (7.5 (3.0–10.0)) warts (p = 0.033) took the longest to heal.ConclusionsHPV biotype is associated with age and the number of warts and appears to influence the natural history of warts and their response to treatment.
Beyond a vestigial organ: effects of the appendix on gut microbiome and colorectal cancer
Authors: Yap Daniel Ren Yi , Lui Rashid N , Samol Jens , Ngeow Joanne , Sung Joseph JY , Wong Sunny H 
Published: February 2024

AbstractThe role of appendectomy in the pathogenesis of colorectal cancer (CRC) is a recent topic of contention. Given that appendectomy remains one of the most commonly performed operations and a first‐line management strategy of acute appendicitis, it is inherently crucial to elucidate the association between prior appendectomy and subsequent development of CRC, as there may be long‐term health repercussions. In this review, we summarize the data behind the relationship of CRC in post‐appendectomy patients, discuss the role of the microbiome in relation to appendectomy and CRC pathogenesis, and provide an appraisal of our current understanding of the function of the appendix. We seek to piece together the current landscape surrounding the microbiome and immunological changes in the colon post‐appendectomy and suggest a direction for future research involving molecular, transcriptomic, and immunologic analysis to complement our current understanding of the alterations in gut microbiome.
Biodiversity impact of food waste: Quantification for supply chain stages and products in Germany
Authors: Bogenreuther Jakob , Kastner Thomas , Schneider Felicitas , Koellner Thomas 
Published: February 2024

AbstractReducing food waste could lower pressures on land resources and thereby contribute to the mitigation of global biodiversity loss. The reduction of food waste and biodiversity loss are also specified in the Sustainable Development Goals 12.3 and 15 of the United Nations. However, which supply chain stages and food products to target with policy measures is hardly known. Especially, a differentiation of the impact after sub‐stages and taxa is still missing and is therefore quantified in the present study. The food waste mass at five supply chain stages and seven sub‐stages in Germany was calculated and differentiated after 204 food products. All products were traced back to their countries of origin, in which their land use impact on mammals, birds, amphibians, reptiles, and plants was quantified. A new approach was developed to calculate the detailed feed demand for animal products. Germany's avoidable food waste (food that was edible before its disposal) leads to 0.3 vertebrate and 1.5 plant species being potentially lost globally. Household‐level waste is responsible for 47% of this species loss, while food services show the largest impact per mass, with individual catering being as influential as one‐person households. The most influential products are obtained from pigs and cattle. Among vertebrate taxa, mainly amphibians are affected, occurring in the mainly affected country Brazil. The results can be used to formulate policies that target, for example, individual catering or display the impact of animal products and their feed demand.
Returnable packaging systems and store operations: Processes, costs, and benefits
Authors: Raible Ina Marie , Holweg Christina , Reiner Gerald , Teller Christoph 
Published: February 2024

AbstractReturnable packaging systems (RPS) related to consumer products help to reduce problematic plastic and glass waste in supply chains. The purpose of this paper is to investigate distribution and return processes and the related cost drivers and benefits of returnable packaging with a deposit refund system in retail stores. Through the lens of the actor–network theory and based on 30 interviews with store managers, including on‐site observations, we develop a research model that structures key processes of RPS and their input and output factors. By subsequently applying system dynamics modeling, we find that: (1) customers’ process satisfaction, (2) price elasticity of demand, and (3) time between repeat purchases are key variables that impact RPS’ attractiveness and performance. This research contributes to an in‐depth understanding of processes within RPS as well as interdependencies between cost drivers and benefits for retailers. From a managerial perspective, these insights can enable retailers to take action based on the influencing factors for efficient operations related to RPS. Finally, this research has policy implications as it provides argumentation for the commercial benefits of RPS for retailers aside from the overemphasized cost perspectives.
Prevalence and variability of restrictive care practice use (physical restraint, seclusion and chemical restraint) in adult mental health inpatient settings: A systematic review and meta‐analysis
Authors: Belayneh Zelalem , Chavulak Jacinta , Lee Den‐Ching A. , Petrakis Melissa , Haines Terry P. 
Published: February 2024

AbstractBackgroundThere is a growing consensus to reduce the use of restrictive care practices in mental health settings to minimise the physical and psychological complications for patients. However, data regarding restrictive care practice use and factors contributing to variations in the proportion estimates has not previously been synthesised.AimsThis study aimed to synthesise evidence on (1) the pooled proportions of physical restraint, seclusion or chemical restraint in adult mental health inpatients and (2) sources of variability in these proportion estimates.MethodsStudies were identified from Scopus, MEDLINE, PsycINFO, Web of Science, Embase and CINAHL databases following the PRISMA 2020 guidelines. We conducted a meta‐analysis of studies published in English language from 1 January 2010 to 15 August 2022. Binomial data were pooled using a random effect model, with 95% confidence intervals. Meta‐regression was also computed to identify factors that may contribute to variations in the proportion estimates.ResultsA total of 77 studies were included in this meta‐analysis. The pooled prevalence of physical restraint, seclusion and chemical restraint was 14.4%, 15.8% and 25.7%, respectively. Data were heterogeneous across studies (I2 > 99%). Reporting practices and geographical locations contributed to the variability in the reported estimates of restrictive care practices, with studies from Asian countries reporting higher proportions.ConclusionThere appear differences between geographical locations in the proportion of restrictive practices in mental health inpatients; however, this is complicated by how these prevalence data have been measured and defined. Consistency in the reporting of restrictive care practices in mental health is required to make valid comparisons between geographical regions, policy settings and practice innovations.Relevance to Clinical PracticeEfforts are needed to develop training programmes and policy changes to ensure consistency in defining and reporting of restrictive care practices in mental health facilities.Patient/Public ContributionThis is a systematic review that analysed data from previously published studies, and there was no patient/public contribution in this study.Protocol RegistrationThe protocol for this review has been registered to PROSPERO: CRD42022335167.
A scoping review of the economic impact of family oral health: Implications for public health, research, and policy
Authors: Herndon Jill Boylston , Rubin Marcie S. , Reusch Colin , Edelstein Burton L. 
Published: February 2024

AbstractObjectivesTo summarize evidence on the impact of oral health on individual and family economic outcomes, describe trends in the literature, and identify areas for additional research to inform public health research and practice.MethodsSearches were conducted within PubMed, CINAHL, EconLit, Cochrane Library, PsycInfo, and Web of Science databases. Article review, selection, abstraction, and reporting processes were guided by the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses Extension for Scoping Reviews.ResultsOf 2758 unduplicated records identified, 52 met inclusion criteria. Study outcomes included indicators of employment/employability (n = 9), earnings/earnings potential (n = 26), parent missed work and family financial impacts of child oral health (n = 19), and financial loss (n = 3). Dental caries‐related variables were the most common predictors of poorer economic outcomes. Other oral health problems, such as poorer dental functioning or poorer self‐reported oral health status, also were associated with adverse economic outcomes. Significant associations with employment were found among studies that assessed interventions designed to improve oral health. Only one study estimated the impact of oral health on earnings. One‐third of studies conducted multivariable analyses, and 14% incorporated race and ethnicity variables.ConclusionsAlthough existing evidence suggests associations between oral health problems and poorer economic outcomes, there is a substantial need for more rigorous research to better understand the extent of economic impact of oral health problems and which populations are most affected. Additional high‐quality research is needed to inform which interventions are most likely to improve oral health, reduce adverse economic impacts, and promote health and economic equity.
How does CEO–TMT exchange quality incongruence affect business model innovation? The moderating role of environmental dynamism
Authors: Chen Yao , Chen Meng , Liu Hefu , Volberda Henk W. , Heij Cornelis V. 
Published: February 2024

AbstractIn today's dynamic business environment, business model innovation (BMI) has become a strategic lever that businesses can harness to unlock new revenue opportunities and fortify their long‐term competitive edge. BMI often hinges on the exchange relationships between chief executive officers (CEOs) and their top management team (TMT) members. However, in practice, CEOs and TMT members often have incongruent perceptions of these relationships, which may impede them from making joint efforts to achieve BMI. When such incongruence arises, relying solely on either the CEO's or the TMT members' perceptions of exchange quality might provide an incomplete understanding of the effect of CEO–TMT exchange quality on BMI. In this study, we investigate how CEO–TMT exchange quality incongruence influences BMI under various levels of environmental dynamism. Using archival industry data and matched survey data from 618 CEOs and 1854 TMT members in China, the polynomial regression and response surface analyses indicate that CEO–TMT exchange quality incongruence negatively affects BMI. This finding suggests that while high perceptions of exchange quality by both CEOs and TMTs independently contribute to BMI, an incongruent perception of exchange quality between CEOs and TMT members can undermine the success of BMI. Moreover, high levels of environmental dynamism aggravate the negative effect of CEO–TMT exchange quality incongruence on BMI. These findings enable us to offer new theoretical insights regarding the influence of the CEO–TMT exchange quality on BMI, thus complementing existing studies on antecedents of BMI and enriching literature on the outcomes of the CEO–TMT interface. Additionally, this study offers practical guidance for enhancing BMI through effective management of incongruent perceptions of CEO–TMT exchanges.
Impact of Problem‐Based Learning Coaching and Neuroeducation in the Development of 21st Century Lifelong Learners
Authors: Coumans Joëlle V. F. , Wark Stuart 
Published: February 2024

AbstractOver the past century, health knowledge has advanced dramatically, so it is expected that future health professionals will need to learn effectively in the workplace and adapt to novel situations that cannot yet be predicted. Simultaneously, the demographics of university students have changed significantly in regard to age, gender, and socioeconomic background. Health educators must adapt their teaching methods to foster in each student the development of lifelong learning skills. This perspective article examines the concept of neuroeducation through the lens of Problem‐Based Learning (PBL), with an emphasis on PBL coaching. Furthermore, it demonstrates the benefit of implementing a PBL coaching approach, using knowledge from neuroscience findings to enhance students' learning and well‐being. Following targeted professional development aiming to consolidate the understanding of the brain's structures and functions that increase student learning capacity and build group coaches' skills, existing PBL academics could be an integral part of such a program.
Nasolabial morphological changes in patients with unilateral cleft lip and palate using a Korat‐modified nasoalveolar moulding appliance with primary correction
Authors: Nirunrungrueng Pinai , Virarat Pongjai , Techalertpaisarn Paiboon , Ungvijanpunya Nicha 
Published: February 2024

AbstractObjectiveThe objective of this study is to measure the morphological changes of the nose and lip in patients with unilateral cleft lip and palate before and after cheiloplasty with primary rhinoplasty (primary correction) in conjunction with Korat‐NAM usage.DesignLongitudinal cohort study.SettingCleft Center Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima, Thailand.SubjectsTwenty‐six patients with unilateral cleft lip and palate.InterventionsControl group: only active obturator before primary correction. Experimental group: an active obturator and Korat‐NAM I before primary correction. A customized endotracheal tube was retained in the nostril for 3 weeks before switching to Korat‐NAM II for 1 year.Main Outcome MeasuresSix measurements comprising nostril rim length, nostril height, nostril sill width, columella angle, vertical lip height, and horizontal lip length were measured from the patients' photographs. All measurements, except the columella angle, were reported as the cleft side/non‐cleft side value ratio. Measurements were taken at the initial appointment, immediately before, 3 weeks after, and 1 year after primary correction.ResultsNostril rim length ratio, nostril height ratio, nostril sill width ratio, columella angle on the cleft side, and vertical lip height ratio were improved using Korat‐NAM before and 3 weeks after primary correction. Nostril rim length and height ratios were significantly better than the control group.ConclusionsKorat‐NAM improved nose and lip morphology before primary correction. An overcorrection improved the nose and lip morphology on the cleft side. The nostril rim length and vertical lip height on the cleft side also improved with Korat‐NAM II 1 year after primary correction.
Asthma and rhinitis control in adolescents and young adults: A real‐world MASK‐air study
Authors: Sousa‐Pinto Bernardo , Valiulis Arunas , Melén Erik , Koppelman Gerard H. , Papadopoulos Nikolaos G. , Makela Mika , Haahtela Tari , Bonini Matteo , Braido Fulvio , Brussino Luisa , Cruz Alvaro A. , Fiocchi Alessandro , Giovannini Mattia , Gemicioglu Bilun , Kulus Marek , Kuna Piotr , Kupczyk Maciej , Kvedariene Violeta , Larenas‐Linnemann Désirée E. , Louis Renaud , Morais‐Almeida Mario , Niedoszytko Marek , Ollert Markus , Pfaar Oliver , Regateiro Frederico S. , Roberts Graham , Samolinski Boleslaw , Savouré Marine , Taborda‐Barata Luis , Toppila‐Salmi Sanna , Ventura Maria Teresa , Vazquez‐Ortiz Marta , Vieira Rafael José , Fonseca Joao A. , Yorgancioglu Arzu , Zuberbier Torsten , Anto Josep M. , Bousquet Jean , Pham‐Thi Nhân ,   the MASK‐air think tank
Published: February 2024

AbstractBackgroundIn allergic rhinitis and asthma, adolescents and young adult patients are likely to differ from older patients. We compared adolescents, young adults and adults on symptoms, control levels, and medication adherence.MethodsIn a cross‐sectional study (2015–2022), we assessed European users of the MASK‐air mHealth app of three age groups: adolescents (13–18 years), young adults (18–26 years), and adults (>26 years). We compared them on their reported rhinitis and asthma symptoms, use and adherence to rhinitis and asthma treatment and app adherence. Allergy symptoms and control were assessed by means of visual analogue scales (VASs) on rhinitis or asthma, the combined symptom‐medication score (CSMS), and the electronic daily control score for asthma (e‐DASTHMA). We built multivariable regression models to compare symptoms or medication accounting for potential differences in demographic characteristics and baseline severity.ResultsWe assessed 965 adolescent users (15,252 days), 4595 young adults (58,161 days), and 15,154 adult users (258,796 days). Users of all three age groups displayed similar app adherence. In multivariable models, age groups were not found to significantly differ in their adherence to rhinitis or asthma medication. These models also found that adolescents reported lower VAS on global allergy, ocular, and asthma symptoms (as well as lower CSMS) than young adults and adults.ConclusionsAdolescents reported a better rhinitis and asthma control than young adults and adults, even though similar medication adherence levels were observed across age groups. These results pave the way for future studies on understanding how adolescents control their allergic diseases.
Novel multispectral imaging to predict disease progression in pediatric morphea
Authors: O'Connor Cathal , McCarthy Siobhan , Kiely Lisa , McAuliffe Michael A. P. , Bennett Mary 
Published: February 2024

AbstractBackgroundMorphea, or localized scleroderma, is an inflammatory, fibrosing skin disorder that can be progressive and debilitating. Infrared thermography frequently has false positive results. The aim of this study was to assess the ability of multispectral imaging to predict disease progression in children with morphea.MethodsChildren with morphea were recruited between 2016 and 2022. Multispectral images of affected and matched contralateral unaffected sites were obtained using the Antera™ 3D camera. Clinical assessment was performed using the Localized Scleroderma Assessment Tool (LoSCAT). Children were followed up every 3 months for imaging and clinical review. The main outcome measurement was correlation of hemoglobin gradient between affected and matched contralateral unaffected tissue and progression.ResultsOf 17 children, the average age was 12 years (range 6–18 years); most were female (76.5%) and white (94.1%). Nearly two‐thirds (64.7%) had linear morphea, 35.2% had plaque morphea; 58.8% had been treated with systemic agents. The average LoSCAT score was 20.6 (range 5–73). The average hemoglobin gradient between affected and matched contralateral unaffected skin was four times higher in those who had progression (average differential 0.3, range 0.1–0.4) compared to those who did not (average differential 0.08, range 0.02–0.15). Using a cut off of a 0.18 hemoglobin gradient between affected and unaffected skin, the sensitivity of multispectral imaging for detecting progression in pediatric morphea is 90% with specificity of 100%.ConclusionsMultispectral imaging is a novel assessment tool with promising accuracy in predicting progression as an adjunct to clinical assessment in pediatric morphea. Further research should examine its performance against thermography.
Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective
Authors: Berglundh Tord , Mombelli Andrea , Schwarz Frank , Derks Jan 
Published: February 2024

AbstractPeri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry. An understanding of the diagnosis, etiology and pathogenesis, epidemiology, and treatment of peri‐implantitis must be a central component in undergraduate and postgraduate training programs in dentistry. In view of the strong role of European research in periodontology and implant dentistry, the focus of this review was to address peri‐implantitis from a European perspective. One component of the work was to summarize new and reliable data on patients with dental implants to underpin the relevance of peri‐implantitis from a population perspective. The nature of the peri‐implantitis lesion was evaluated through results presented in preclinical models and evaluations of human biopsy material together with an appraisal of the microbiological characteristics. An overview of strategies and outcomes presented in clinical studies on nonsurgical and surgical treatment of peri‐implantitis is discussed with a particular focus on end points of therapy and recommendations presented in the S3 level Clinical Practice Guideline for the prevention and treatment of peri‐implant diseases.