bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intracholecystic papillary neoplasm acquiring malignant characteristics and leading to multiple liver metastases: A case report
Authors: Suda Tsuyoshi , Sato Yasunori , Ito Yusuke , Kaji Kiichiro , Terasaki Shuichi , Nakanuma Yasuni 
Published: November 2023

AbstractThe mechanisms underlying the progression of intracholecystic papillary neoplasms (ICPNs) to gallbladder cancer and invasive cancer remain relatively unclear. In the present case, metastatic liver tumors were suspected in an 83‐year‐old man at presentation; however, the primary tumor was unknown. The patient died shortly thereafter as a result of rapid tumor progression. An autopsy revealed multiple liver, lung, and lymph node metastases. Additionally, a fragile papillary tumor with a high‐grade dysplastic epithelium with tubulopapillary morphology and admixed foci of a low‐grade dysplastic epithelium were detected at the fundus of the gallbladder. The well‐differentiated tubular adenocarcinoma had extensively invaded the wall's granular mucosal surface along with the solitary papillary tumor. Based on pathological findings, a diagnosis of an ICPN with an associated invasive carcinoma was established. This case is novel because it showed that an ICPN can progress aggressively.
Dark Blood Contrast‐Enhanced Brain MRI Using Echo‐uT1RESS
Authors: Edelman Robert R. , Leloudas Nondas , Ankenbrandt William J. , Walker Matthew T. , Bobustuc George C. , Bailes Julian E. , Pruitt Aaron A. , Koktzoglou Ioannis 
Published: November 2023

BackgroundThe widely used magnetization‐prepared rapid gradient‐echo (MPRAGE) sequence makes enhancing lesions and blood vessels appear bright after gadolinium administration. However, dark blood imaging using T1‐weighted Sampling Perfection with Application optimized Contrast using different flip angle Evolution (T1 SPACE) can be advantageous since it improves the conspicuity of small metastases and leptomeningeal disease. As a potential alternative to T1 SPACE, we evaluated a new dark blood sequence called echo‐uT1RESS (unbalanced T1 Relaxation‐Enhanced Steady‐State).PurposeWe compared the performance of echo‐uT1RESS with Dixon fid‐uT1RESS, MPRAGE, and T1 SPACE.Study TypeRetrospective, IRB approved.Subjects/PhantomPhantom to assess flow properties of echo‐uT1RESS. Twenty‐one patients (14 female, age range 35–82 years) with primary and secondary brain tumors.Field Strength/Sequences3 Tesla/MPRAGE, T1 SPACE, Dixon fid‐uT1RESS, echo‐uT1RESS.AssessmentFlow phantom signal vs. velocity as a function of flip angle and sequence. Qualitative image assessment on 4‐point scale. Quantitative evaluation of tumor‐to‐brain contrast, apparent contrast‐to‐noise ratio (aCNR), and vessel‐to‐brain aCNR.Statistical TestsFriedman and Mann–Whitney U tests. A P value <0.05 was considered statistically significant.ResultsIn the phantom, echo‐uT1RESS showed greater flow‐dependent signal loss than fid‐uT1RESS. In patients, blood vessels appeared bright with MPRAGE, gray with fid‐uT1RESS, and dark with T1 SPACE and echo‐uT1RESS. For MPRAGE, Dixon fid‐uT1RESS, echo‐uT1RESS, and T1 SPACE, respective tumor‐to‐brain contrast values were 0.6 ± 0.3, 1.3 ± 0.5, 1.0 ± 0.4, and 0.6 ± 0.4, while normalized aCNR values were 68.9 ± 50.9, 128.4 ± 59.2, 74.2 ± 42.1, and 99.4 ± 73.9.Data ConclusionVolumetric dark blood contrast‐enhanced brain MRI is feasible using echo‐uT1RESS. The dark blood effect was improved vs. fid‐uT1RESS, while both uT1RESS versions provided better tumor‐to‐brain contrast than MPRAGE. Whereas T1 SPACE provided better tumor aSNR, echo‐uT1RESS provided better Weber contrast, lesion sharpness and a more consistent dark blood effect.Evidence Level3Technical EfficacyStage 1
A case of extrapyramidal side effects due to possible paliperidone: voriconazole interaction
Authors: Beilby Louise , Arno Lucy 
Published: November 2023

AbstractBackgroundIt is thought that paliperidone, an active metabolite of risperidone, has limited potential for pharmacokinetic drug–drug interactions (DDIs) due to minimal metabolism by cytochrome P450 3A4 (CYP3A4) and cytochrome P450 2D6 (CYP2D6). However, DDIs have been reported and include a theoretical interaction between paliperidone and voriconazole based on interactions between risperidone and strong CYP3A4 inhibitor azoles.AimTo describe the first recorded DDI between paliperidone and voriconazole leading to extrapyramidal side effects (EPSEs).Clinical detailsA 34‐year‐old male presented with febrile neutropenia presumed due to clozapine. Clozapine was ceased and paliperidone commenced with voriconazole added to the patient's empiric piperacillin/tazobactam therapy due to a suspected fungal infection. Two days after starting voriconazole, the patient developed hypertonia and hyperreflexia in all limbs, thought most likely to be antipsychotic induced EPSEs. Paliperidone was withheld and EPSEs resolved.OutcomesThe patient had previously tolerated long‐term paliperidone at higher doses, prior to transitioning to clozapine. The development of EPSEs occurred two days post azole initiation, indicating a probable paliperidone adverse drug reaction (ADR) due to strong CYP3A4 inhibition by voriconazole. This case appears to be the first documented report of this previous theoretical DDI in practice. Further studies, including therapeutic drug monitoring, are required to confirm findings.ConclusionPaliperidone may be affected by pharmacokinetic drug–drug interactions and patients should be monitored for ADRs when CYP3A4 inhibitors are concomitantly administered.
Study on the interaction and gel properties of pork myofibrillar protein with konjac polysaccharides
Authors: Liu Jingyang , Yang Kun , Wu Di , Gong Honghong , Guo Linxiao , Ma Jing , Sun Weiqing 
Published: November 2023

AbstractBackgroundNatural myofibrillar protein (MP) is sensitive to changes in the microenvironment, such as pH and ionic strength, and therefore can adversely affect the final quality of meat products. The aim of this study was to modify natural MP as well as to improve its functional properties. Therefore, the quality improvement effect of konjac polysaccharides with different concentrations (0, 1.5, 3, 4.5 and 6 g kg−1 protein) on MP gels was investigated.ResultsWith a concentration of konjac polysaccharides of 6 g kg−1 protein, the composite gel obtained exhibited a significant improvement of water binding (water holding capacity increased by 7.71%) and textural performance (strength increased from 29.12 to 37.55 N mm, an increase of 8.43 N mm). Meanwhile, konjac polysaccharides could help to form more disulfide bonds and non‐disulfide covalent bonds, which enhanced the crosslinking of MP and maintained the MP gel network structure. Then, with the preservation of α‐helix structure (a significant increase of 8.11%), slower protein aggregation and formation of small aggregates, this supported the formation of a fine and homogeneous network structure and allowed a reduction in water mobility.ConclusionDuring the heating process, konjac polysaccharides could absorb the surrounding water and fill the gel system, which resulted in an increase in the water content of the gel network and enhanced the gel‐forming ability of the gel. Meanwhile, konjac polysaccharides might inhibit irregular aggregation of proteins and promote the formation of small aggregates, which in turn form a homogeneous and continuous gel matrix by orderly arrangement. © 2023 Society of Chemical Industry.
Destructive and non‐destructive early detection of postharvest noble rot (Botrytis cinerea) in wine grapes aimed at producing high‐quality wines
Authors: Modesti Margherita , Alfieri Gianmarco , Chieffo Chiara , Mencarelli Fabio , Vannini Andrea , Catalani Alessia , Chilosi Gabriele , Bellincontro Andrea 
Published: November 2023

AbstractBACKGROUNDBotrytis cinerea (Bc) is the causative agent of gray mold disease in wine grape bunches. Under particular climatic and edaphic conditions, typical of some wine regions, the grapes infected by this fungus can develop noble rot, the basic phenomenon for the production of sweet botrytized wines or some high‐quality dry wines, such as Amarone. The possibility of early detection of noble rot on plants and at postharvest is an interesting option for managing botrytized wines.RESULTSThe present work aimed at early detection of noble rot and monitoring its development, at postharvest, on Trebbiano wine grapes by means of destructive and non‐destructive analytical approaches (e.g., electronic nose and near‐infrared spectroscopy). The development of Bc led to substantial modifications in grape composition, including dehydration, biosynthesis, and accumulation of different compounds due to Bc metabolism, grape stress responses, or both. However, these modifications are appreciable, notably at advanced stages of infection. Consequently, a specific focus was to monitor the infection in the first 72 h post inoculation for testing, potentially through non‐destructive technologies, and to identify the real early stages of Bc development.CONCLUSIONThe destructive chemical analyses performed over the 16 monitored days confirmed what is widely reported in the literature regarding the metabolic/compositional changes that occur following the development of Bc. Moreover, non‐destructive technologies allowed us to identify the evolution of Bc, even at early stages of its presence. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
The promising stability of carboxylpyranocyanidin‐3‐O‐glucoside during food processing and simulated digestion and its bioavailability research
Authors: Li Xusheng , Yuan Kailan , Zhang Yulin , Liu Chuqi , Cai Dongbao , Sun Jianxia , Lai Caiyong , Bai Weibin 
Published: November 2023

AbstractBACKGROUNDPyranoanthocyanins are stable anthocyanin derivatives. Carboxylpyranoanthocyanin is one of the simplest pyranoanthocyanin, among which the production of carboxylpyranocyanidin‐3‐O‐glucoside (crboxyl‐pycy‐3‐gluc) is most feasible as a result of the abundance of its reactant, cyanidin‐3‐O‐glucoside (Cy‐3‐gluc).RESULTSIn the present study, carboxyl‐pycy‐3‐gluc was synthesized and its stability during processing and after ingestion as well as its bioavailability in vivo were comprehensively evaluated. Our results indicated that the color of carboxyl‐pycy‐3‐gluc remained more stable compared to Cy‐3‐gluc when facing the large‐span pH variation. The high retention of anthocyanin symbolized the superb stability under thermal processing, sulfur dioxide bleaching and ultrasonic treatment of carboxyl‐pycy‐3‐gluc. Because of the stability under the alkaline condition, carboxyl‐pycy‐3‐gluc is more stable after oral‐gastrointestinal digestion. After in vitro gut microbiota fermentation, the retention of carboxyl‐pycy‐3‐gluc was significantly higher than that of Cy‐3‐gluc. The larger molecular size made absorption of carboxyl‐pycy‐3‐gluc into blood more difficult than its precursor.CONCLUSIONThe present study demonstrated the promising stability of carboxyl‐pycy‐3‐gluc during food processing and after digestion, confirming the potential of carboxyl‐pycy‐3‐gluc as a colorant. © 2023 Society of Chemical Industry.
Antireflective Multi‐Dielectric Metasurfaces Operating in the Visible
Authors: Koksal Okan , Song Junyeob , Wang Zi , Chen Lu , Zhu Wenqi , Agrawal Amit 
Published: November 2023

AbstractAs increasingly more demanding photonics applications are brought on‐chip, more complex design solutions are employed to deliver enhanced performance: e.g., meta‐molecules, inverse‐designed freeform structures, and multilayer metasurfaces. Instead, this study introduces anti‐reflective metasurfaces fabricated in a single nanolithography step that follows deposition of multiple dielectrics onto a substrate. Anti‐reflective metasurfaces offer fundamentally better transmission efficiencies compared to conventional equivalents. Conventional and anti‐reflective metalenses, both fabricated in the Ta2O5/SiO2 material platform for 461 nm operation, show an improvement in focusing efficiencies from ≈ 55% to ≈ 90% at low numerical apertures and from ≈ 35% to ≈ 65% at high numerical apertures. Simulations of ideal and imperfect metalenses indicate that anti‐reflective metasurfaces not only improve transmission at the design library level, but also reduce spurious diffraction and protect against higher‐order scattering.
Hyperbranched Poly‐L‐Lysine‐Based Water‐Insoluble Complexes as Antibacterial Agents with Efficient Antibacterial Activity And Cytocompatibility
Authors: Chen Qi , Xu Yuanjing , Feng Jingyi , Lv Xingshuang , Fu Xiaohui , Yuan Shuaishuai , Li Zhibo 
Published: November 2023

AbstractDespite the advances in technology, bacterial infection associated with biomedical devices is still one of the most challenging issues in clinical practice. Incorporation of antimicrobial agents is regarded as an efficient way to combat medical device associated infectious. However, most of antimicrobial agents have high toxicity to host cells. Thus, fabrication of novel antimicrobial agents that simultaneously fulfill the requirements of antibacterial activity as well as biocompatibility is urgently needed. Herein, a series of water‐insoluble antibacterial complexes based on hyperbranched poly‐L‐lysine (HBPL) and four different surfactants through non‐covalent interactions are developed. Such kinds of surfactants have great effects on the antibacterial property of poly(ɛ‐caprolactone) (PCL) films that incorporate with the HBPL‐based complexes. The results reveal that the PCL films that doped with HBPL/phosphate ester surfactant complexes showed the highest bacterial killing efficiency. Moreover, the cytocompatibility of the composite films is also investigated. Hemolysis experiments indicate that all the films had low hemolytic activities. Considering the excellent antimicrobial and cytocompatibility properties, this work believes that the optimized complexes have great potential to be used as antimicrobial agents in biomedical field.
Distributed adaptive control for multiple unmanned aerial vehicles with state constraints and input quantization
Authors: Qian Moshu , Le Tian , Wang Cunsong , Wang Ronghao , Bo Cuimei 
Published: November 2023

AbstractThis paper investigates the distributed fault‐tolerant tracking control (FTTC) problem for multiple unmanned aerial vehicles (UAVs) in the presence of state constraints, input quantization and actuator failures. The unified barrier function (UBF) is first developed to convert the original constrained system model into an unconstrained one, which accomplishes the dynamic constraints of all states. Moreover, a cerebellar model neural network (CMNN) is introduced to estimate the lumped effect of unknown disturbances and actuator failures. Then, a distributed formation flight fault‐tolerant controller (FTC) is designed to guide the UAVs along the desired trajectories based on sliding mode manifold and dynamic surface control technique. Meanwhile, the unknown input chattering and hysteresis quantizer errors in the UAVs system are simultaneously handled by adding the compensation term of FTC. Furthermore, the finite time stability analysis is implemented for all tracking errors and synchronization errors of the cooperative flight control system (CFCS). Finally, a comparative simulation is conducted to demonstrate the effectiveness of the FTTC scheme proposed in this study.
Social participation of school‐aged survivors of pediatric brain tumors: A daily diary report
Authors: Tamboli Mollie , Means Bethany , Jurbergs Niki , Conklin Heather M. , Gajjar Amar , Willard Victoria W. 
Published: November 2023

AbstractBackgroundDifficulties with social functioning are common among survivors of pediatric brain tumors. Social participation is an understudied measure of social functioning that is associated with emotional health across the lifespan. This paper uses a diary method to assess the social participation of survivors of pediatric brain tumors in middle childhood.ProcedureSurvivors of pediatric brain tumors (N = 47; age 10.6 ± 1.4 years; 51.1% male, 89.4% White) who were 5.3 (SD = 2.4, range: 2–9.9) years post therapy completed a daily diary assessment of social interaction (5–7 days) and an objective measure of facial affect recognition. The participant's caregiver completed the NIH Toolbox Emotion Measures and a background information questionnaire.ResultsOverall, frequency and quality of reported social interactions were low for survivors, with a large subset of survivors (n = 16, 34%) endorsing fewer than 10 social interactions over the course of a typical school week, and almost half of parents (48.9%) reporting that their child participates in zero social activities outside of school during a typical week. Participants engaged in more positive social participation exhibited stronger social skills (facial affect recognition (F(2,44) = 4.85, p < .05).ConclusionsSchool‐aged survivors of pediatric brain tumors seemed to be infrequently engaged in social participation and quality interaction with peers. More specifically, the interactions most commonly reported on the diary assessment are not indicative of friendship development and maintenance. Survivors of pediatric brain tumors would likely benefit from interventions designed to increase quality time spent with peers.
MPA‐Pred: A machine learning approach for predicting the binding affinity of membrane protein–protein complexes
Authors: Ridha Fathima , Gromiha M. Michael 
Published: November 2023

AbstractMembrane protein–protein interactions are essential for several functions including cell signaling, ion transport, and enzymatic activity. These interactions are mainly dictated by their binding affinities. Although several methods are available for predicting the binding affinity of protein–protein complexes, there exists no specific method for membrane protein–protein complexes. In this work, we collected the experimental binding affinity data for a set of 114 membrane protein–protein complexes and derived several structure and sequence‐based features. Our analysis on the relationship between binding affinity and the features revealed that the important factors mainly depend on the type of membrane protein and the functional class of the protein. Specifically, aromatic and charged residues at the interface, and aromatic‐aromatic and electrostatic interactions are found to be important to understand the binding affinity. Further, we developed a method, MPA‐Pred, for predicting the binding affinity of membrane protein–protein complexes using a machine learning approach. It showed an average correlation and mean absolute error of 0.83 and 0.91 kcal/mol, respectively, using the jack‐knife test on a set of 114 complexes. We have also developed a web server and it is available at https://web.iitm.ac.in/bioinfo2/MPA-Pred/. This method can be used for predicting the affinity of membrane protein–protein complexes at a large scale and aid to improve drug design strategies.
Non‐medical oocyte cryopreservation at a single center in Japan: 8 years of experience
Authors: Yoshinaga Koki , Hashimoto Tomoko , Fukuoka Yuriko , Okuyama Noriyuki , Kyono Koichi 
Published: November 2023

AbstractPurposeIncreasing numbers of women are opting to undergo non‐medical oocyte cryopreservation (NMOC). In this report, we present experience at our clinic and discuss NMOC in Japan.MethodsWe followed the progress of 403 women who underwent NMOC at our clinic between 2014 and 2021, totaling 592 reproductive cycles.ResultsIn total, 61 women underwent oocyte warming and fertility treatment. Of these, 13 women gave birth to 14 children. The median age at first oocyte cryopreservation was 38.3 years, and the oldest pregnant woman was 42 years. Most clients (60%) were in their late 30s. The median time between first oocyte cryopreservation and warming was 3.0 years. One woman was able to achieve a live birth with four vitrified oocytes.ConclusionsThis is the first report in Japan documenting pregnancies and childbirths resulting from NMOC. Ideally, women hope to achieve natural pregnancy between 20 and 32 years of age. NMOC is an option for individuals who are unable to pursue pregnancy during optimal reproductive years and wish to preserve their fertility for future attempts. NMOC is recommended in cases with few indications, and it is necessary to continue accumulating data on its long‐term safety and effectiveness.
Tributary mitigates river discontinuity by dam depending on the distance from dam to the tributary confluence
Authors: Katano Izumi , Doi Hideyuki , Negishi Junjiro N. , Minagawa Tomoko , Kayaba Yuichi 
Published: November 2023

AbstractRiver ecosystems host a continuum of various discontinuities, such as dams and tributary inflows, which shape the habitats of aquatic organisms; this makes it important to evaluate the interactions among discontinuities and effects of a single discontinuity point. Herein, we focused on tributaries in dammed rivers to elucidate a manner to mediate discontinuities and hypothesized that the effects of the tributary inflow on the downstream river were mediated by the (1) distance between the dam and tributary inflow, (2) size ratio between the dam and tributary, and (3) ability of the tributary to transport fine sediments, such as sand and gravel. We conducted field investigations to measure 24 environmental factors, including the water column, riverbed, and river topography, along eight dammed rivers to test the three hypotheses. Only five factors differed significantly between the upstream and downstream sites of the tributary confluence, whereas 12 factors differed significantly between the tributary and mainstem. We also classified the variation pattern using principal component analysis (PCA). The correlation between each PCA axis and environmental factors suggests that the modifications of the water quality factors by tributary inflow were significantly correlated with the distance between the dam and the tributary inflow, and that the flux of various riverbed factors, that is, was significantly correlated with the ability to resupply of fine riverbed sediments by the tributary. Overall, tributary‐inflow downstream of a dam has the potential to be applicable in environmental restoration, especially in terms of resupplying fine sediment.