bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reward Modulates Visual Responses in the Superficial Superior Colliculus of Mice
Authors: Baruchin Liad J. , Alleman Matteo , Schröder Sylvia 
Published: October 2023

The processing of sensory input is constantly adapting to behavioral demands and internal states. The drive to obtain reward, e.g., searching for water when thirsty, is a strong behavioral demand and associating the reward with its source, a certain environment or action, is paramount for survival. Here, we show that water reward increases subsequent visual activity in the superficial layers of the superior colliculus (SC), which receive direct input from the retina and belong to the earliest stages of visual processing. We trained mice of either sex to perform a visual decision task and recorded the activity of neurons in the SC using two-photon calcium imaging and high-density electrophysiological recordings. Responses to visual stimuli in around 20% of visually responsive neurons in the superficial SC were affected by reward delivered in the previous trial. Reward mostly increased visual responses independent from modulations due to pupil size changes. The modulation of visual responses by reward could not be explained by movements like licking. It was specific to responses to the following visual stimulus, independent of slow fluctuations in neural activity and independent of how often the stimulus was previously rewarded. Electrophysiological recordings confirmed these results and revealed that reward affected the early phase of the visual response around 80 ms after stimulus onset. Modulation of visual responses by reward, but not pupil size, significantly improved the performance of a population decoder to detect visual stimuli, indicating the relevance of reward modulation for the visual performance of the animal.SIGNIFICANCE STATEMENTTo learn which actions lead to food, water, or safety, it is necessary to integrate the receiving of reward with sensory stimuli related to the reward. Cortical stages of sensory processing have been shown to represent stimulus-reward associations. Here, we show, however, that reward influences neurons at a much earlier stage of sensory processing, the superior colliculus (SC), receiving direct input from the retina. Visual responses were increased shortly after the animal received the water reward, which led to an improved stimulus signal in the population of these visual neurons. Reward modulation of early visual responses may thus improve perception of visual environments predictive of reward.
Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice
Authors: Barnhoorn Sander , Meima Marcel E , Peeters Robin P , Darras Veerle M , Leeuwenburgh Selmar , Hoeijmakers Jan H J , Vermeij Wilbert P , Visser W Edward 
Published: October 2023

Background
Thyroid hormone signaling is essential for development, metabolism, and response to stress but declines during aging, the cause of which is unknown. DNA damage accumulating with time is a main cause of aging, driving many age-related diseases. Previous studies in normal and premature aging mice, due to defective DNA repair, indicated reduced hepatic thyroid hormone signaling accompanied by decreased type 1 deiodinase (DIO1) and increased DIO3 activities. We investigated whether aging-related changes in deiodinase activity are driven by systemic signals or represent cell- or organ-autonomous changes.

Methods
We quantified liver and plasma thyroid hormone concentrations, deiodinase activities and expression of T3-responsive genes in mice with a global, liver-specific and for comparison brain-specific inactivation of Xpg, one of the endonucleases critically involved in multiple DNA repair pathways.

Results
Both in global and liver-specific Xpg knockout mice, hepatic DIO1 activity was decreased. Interestingly, hepatic DIO3 activity was increased in global, but not in liver-specific Xpg mutants. Selective Xpg deficiency and premature aging in the brain did not affect liver or systemic thyroid signaling. Concomitant with DIO1 inhibition, Xpg
−/− and Alb-Xpg mice displayed reduced thyroid hormone-related gene expression changes, correlating with markers of liver damage and cellular senescence.

Conclusions
Our findings suggest that DIO1 activity during aging is predominantly modified in a tissue-autonomous manner driven by organ/cell-intrinsic accumulating DNA damage. The increase in hepatic DIO3 activity during aging largely depends on systemic signals, possibly reflecting the presence of circulating cells rather than activity in hepatocytes.
A 20-year study of autoimmune polyendocrine syndrome type II and III in Taiwan
Authors: Tseng Hsu-Hua , Lin Yen-Bo , Lin Kuan-Yu , Lin Chia-Hung , Li Hung-Yuan , Chang Chia-Hsuin , Tung Yi-Ching , Chen Pei-Lung , Wang Chih-Yuan , Yang Wei-Shiung , Shih Shyang-Rong 
Published: October 2023

Purpose
Autoimmune polyendocrine syndrome (APS) is a rare immune-endocrinopathy characterized by the failure of at least two endocrine organs. Clinical characteristics have mainly been described in the Western population. This study comprehensively analyzed the demographic and clinical manifestations of APS II and APS III in Taiwan.

Methods
Patients aged ≥20 years with a diagnosis of APS II or APS III in ten hospitals between 2001 and 2021 were enrolled. The clinical and serological characteristics of the patients were retrospectively reviewed.

Results
Among the 187 enrolled patients (45 men and 142 women); only seven (3.7%) had APS II, while the others had APS III. Fifty-five patients developed hyperthyroidism and 44 patients developed hypothyroidism. Men were diagnosed with APS at a younger age than women (16.8 vs 27.8 years old, P = 0.007). Most patients were initially diagnosed with type 1 diabetes mellitus. There was a positive correlation between age at diagnosis and the likelihood of developing thyroid dysfunction. For every year older patients were diagnosed with APS III, the risk of developing hyperthyroidism increased by 3.6% (P = 0.002), and the risk of developing hypothyroidism increased by 3.7% (P = 0.035). Positive anti-parietal cell antibodies (APCA) were associated with a higher risk of anemia in patients with APS III (P < 0.001).

Conclusion
This study provides the most comprehensive analysis of APS II and APS III in Asia. The percentage of patients with APS II was significantly lower than in the Western population. A second autoimmune endocrinopathy may develop several years after the first one. APCA examination is valuable when evaluating anemia in patients with APS.
The Effect of Environmental Tax - Spending Mix on Province Air Quality
Authors: Qibthiyyah Riatu Mariatul , Zen Fauziah 
Published: October 2023

The provincial government in Indonesia has been mandated to collect environmental-related taxes in recurrent vehicle taxes, vehicle transfer taxes, and gasoline taxes. These vehicle-related taxes have been the dominant type for the provincial government. Yet, the environment-related spending has been relatively low, within 1-3% of total expenditures. This study examines to what extent such environmental tax–spending mix affects the environmental outcomes measured by the air quality index. The novelty of this study comes in using detailed environmental-related tax revenues at the sub-national level and providing a context of the large developing country in a decentralized economy – Indonesia – as a case study. Our study finds the link between environmental tax in the case of the vehicle recurrent tax and gasoline tax in improving air quality and environmental quality index, respectively. But on the spending side, there is no evidence that provincial environmental spending may improve the air or environmental quality index. Nonetheless, we found a correlation between the vehicle transfer tax revenues and the share of province environmental spending, implying that environmental tax revenues, to some extent, correspond to the related provincial expenditures on environmental protection. This study signals the need also to expand environmental spending to complement existing environmental tax policy at the provincial level.JEL Classification: H71, H76, Q53How to Cite:Qibthiyyah, R. M., & Zen, F. (2023). The Effect of Environmental Tax Spending Mix on Province Air Quality Index. Signifikan: Jurnal Ilmu Ekonomi, 12(2), 221-230. https://doi.org/10.15408/sjie.v12i2.32395.
Banking Selection Criteria among Millennials: Insights from Islamic and Conventional Banks
Authors: Rama Ali , Wiranata Suhenda 
Published: October 2023

The increasing number of millennials presents an enticing market opportunity for business. Understanding their preferences is the key to attracting their sympathy and interest. Thus, this study aims to analyze banking selection criteria for Islamic and conventional banks among the young generation. A group of students represents the millennial group in this study. Data is collected through questionnaire instruments, and factor analysis is employed to capture millennials' preference for banking. The finding highlights a relatively lower level of knowledge and awareness among millennials regarding the products and services offered by Islamic banks. Interestingly, among them, an inverse relationship exists between the criteria for selecting Islamic and conventional banks. Factors associated with banking preference among millennials are managerial performance and service quality, religiosity, recommendations, and finances. This study provides valuable insights for banking industry players, enabling them to understand millennial banking preferences better and formulate suitable marketing strategies.JEL Classification: G21, G32, D81How to Cite:Rama, A., & Wiranata, S. (2023). Banking Selection among Millennials: Insights from Islamic and Conventional Banks. Signifikan: Jurnal Ilmu Ekonomi, 12(2), 341-354. https://doi.org/10.15408/sjie.v12i2.35104.
Learning from nature by leveraging integrative biomateriomics modeling toward adaptive and functional materials
Authors: Arevalo Sofia E. , Buehler Markus J. 
Published: October 2023

AbstractBiological systems generate a wealth of materials, and their design principles inspire and inform scientists from a broad range of fields. Nature often adapts hierarchical multilevel material architectures to achieve a set of properties for specific functions, providing templates for difficult tasks of understanding the intricate interplay between structure–property–function relationships. While these materials tend to be complex and feature intricate functional interactions across scales, molecular-based multiscale modeling, machine learning, and artificial intelligence combined with experimental approaches to synthesize and characterize materials have emerged as powerful tools for analysis, prediction, and design. This article examines materiomic graph-based modeling frameworks for assisting researchers to pursue materials-focused studies in a biological context, and provides an overview of methods that can be applied to bottom-up manufacturing, including a historical perspective of bioinspired materials research. Through the advent of novel modeling architectures and diverse systems from nature, there is potential to develop materials with improved properties.
Graphical abstract
Shape memory thermoplastic polyurethane/polycaprolactone blend and composite with hydroxyapatite for biomedical application
Authors: Pinto Leonardo Alves , Backes Eduardo Henrique , Harb Samarah Vargas , Pinto Gabriel Matheus , da Cunha Daniel Aparecido Lopes Vieira , Andrade Ricardo Jorge Espanhol , Fechine Guilhermino José Macêdo , Selistre-de-Araújo Heloisa Sobreiro , Costa Lidiane Cristina , Pessan Luiz Antonio 
Published: October 2023

AbstractDepending on its composition, thermoplastic polyurethane (TPU)/polycaprolactone (PCL) blend may present interesting properties for biomedical applications. Here, we have extensively developed and characterized blends of TPU/PCL and composites with 5, 10, and 20 wt% of hydroxyapatite (HA). The thermal, rheological, and mechanical characterizations showed that the blends present an intermediate behavior between pure TPU and PCL. The 75TPU/25PCL blend exhibited the best shape memory performance at temperatures below 50 °C. Filaments of this blend presented a fixation rate of 86.6% and a recovery rate of 73.3% at 50 ℃. The addition of HA had little influence on the shape memory properties; on the other hand, it strengthened the material, reaching elastic modulus values close to 100 MPa. In vitro tests revealed a biocompatible behavior for all blends, and the composite with 10 wt% HA from the 75TPU/25PCL blend demonstrated greater cell proliferation compared to the other composites.
Graphical abstract
Photoinduced modification of optical properties of ferroelectric PZT thin films
Authors: Yousefi Saeed , Hua Nelson , Mehta Jugal , Li Jianheng , Guillemot Loïc , Rippy Geoffery , Zhong Louie , Schaller Richard D. , Maroutian Thomas , Haldrup Kristoffer , Matzen Sylvia , Kukreja Roopali 
Published: October 2023

AbstractThis study investigates ultrafast photoinduced changes in optical properties of ferroelectrics (PZT) on femtosecond to nanosecond timescales, using broadband transient reflectivity studies. Surprisingly, spectral features were observed below the bandgap, which could not be attributed to ground state bleaching, excited state absorption, and/or stimulated emission. A model based on probe energy independent changes in refractive index and extinction coefficient showed good agreement with experimental results. Three relaxation processes were phenomenologically considered for the temporal evolution. Laser-induced heating was ruled out as the cause of short timescale behavior and photorefractive effect was suggested as a potential mechanism for changes in the optical properties.Graphical abstract
Polemika na temat natury małżeństwa na łamach „Ateneum Kapłańskiego” z projektem prawa małżeńskiego Komisji Kodyfikacyjnej w okresie międzywojennym
Authors: Skoczylas Kazimierz 
Published: October 2023

Polska rodzina po odzyskaniu niepodległości doświadczała wielu okoliczności, które miały wpływ na jej funkcjonowanie. Członkowie rodzin charakteryzowali się niskim wykształceniem, doświadczali chorób, bezrobocia, głodu, a wielu nie znajdując godnych warunków do życia udawała się na emigrację. Po pierwszej wojnie światowej pozostała wielka liczba sierot. Państwo na miarę swoich możliwości starało się poprawiać los rodzin. Duże znaczenie w nowym państwie złożonym z terenów po dawnych zaborach miało stworzenie nowego prawa, w tym także prawa małżeńskiego i rodzinnego. Tym zajmowała się powołana przez Państwo w 1919 roku Komisja Kodyfikacyjna. Ona też przygotowała projekt prawa rodzinnego opublikowany w 1931 roku, nad którym trwała dyskusja. W tej dyskusji uczestniczyło środowisko katolickie, a w jego obrębie redakcja „Ateneum Kapłańskiego”. W czasopiśmie „Ateneum Kapłańskie” podejmowano dyskusję na temat problematyki rodzinnej wykraczającą treściami poza obszar prawa. Jednak dyskusja prowadzona na jego łamach nad projektem prawa małżeńskiego Komisji Kodyfikacyjnej odegrała dużą rolę w środowisku katolickim. Ta dyskusja miała wpływ na dalszy przebieg procesu kodyfikacji.
Wierni wobec wytycznych Kościoła katolickiego w Polsce. Pierwszy rok pandemii COVID-19
Authors: Wąchol Grzegorz 
Published: October 2023

Artykuł jest podsumowaniem badań, jakie zostały przeprowadzone w lutym i marcu 2021 roku wśród wiernych świeckich, na temat postanowień duszpasterskich Kościoła katolickiego w Polsce podczas pandemii COVID-19. Autor uzyskał kilka tysięcy wypowiedzi wiernych, którzy od roku zmagali się ze zjawiskiem pandemii zagrażającym zdrowiu i życiu nie tylko w wymiarze fizycznym, ale również duchowym. Po krótkim teoretycznym wprowadzeniu w problematykę podejmowanego tematu nastąpi analiza wyników badań.
Crónica del Congreso Internacional de casos prácticos. Innovación docente y Derecho global tras la pandemia, celebrado In Memoriam del Profesor Justo García Sánchez en la Universidad de Oviedo, España, el 28 y 29 de Septiembre del 2023
Authors: García Fueyo Beatriz 
Published: October 2023

Relato sucinto de todas las intervenciones del pasado Congreso Internacional de casos prácticos. Innovación docente y Derecho global tras la pandemia in memoriam del profesor D. Justo García Sánchez, celebrado en la Universidad de Oviedo a finales del mes de Septiembre 2023.
A retrospective study of invasive fungal rhinosinusitis in adults for surgical outcomes at tertiary care hospital
Authors: Trivedi Keval R. , Shah Chaitry 
Published: October 2023

Background: An invasive fungal rhinosinusitis is most lethal form of sinusitis. It includes acute and chronic invasive fungal rhinosinusitis. The most lethal fungi are Aspergillous species and mucormycosis, others are Alternaria, P. boydii and Sprothrix. Endoscopic debridement combined with intravenous antifungals are efficacious in management of invasive fungal rhinosinusitis.
Methods: Study conducted at department of otorhinolaryngology, GMERS Medical College and Hospital, Sola, Ahmedabad. The period of the study October 2020 to October 2022. Total 100 cases taken. All cases of biopsy proven invasive fungal rhinosinusitis above the age of 18 years are included in this study. Oral and written consent taken from all included patients. A nasal endoscopy followed by KOH mount, magnetic resonance imaging – peripheral nervous system (MRI PNS) done.
Results: In our study, 57% patients were surgically treated with functional endoscopic sinus surgery, 23% patients treated with modified Denker’s approach debridement. On basis of MRI PNS, nasal endoscopy and symptomatic improvement of the disease, only 10 patients have recurrence of disease and 90 patients are completely recovered after surgical and medical management.
Conclusions: Maintaining high index of suspicion in at risk patient populations, followed by prompt evaluation and management is crucial in suspected invasive fungal rhinosinusitis. Early management with antifungal e.g. Amphotericin B intravenous injections, tab Posaconazole, tab Voriconazole and surgical intervention e.g. FESS, modified Denker’s approach debridement, FESS with middle meatal antrostomy very efficacious in terms of preventing the recurrence and mortality in patients.
Antenatal screening for Thalassemia minor among conceiving females: A preventive measure
Authors: Mehmood Sehrish , Yousuf Pervaiz , Shaiq Pakeeza Arzoo , Khalil Safia , Habiba Umme 
Published: October 2023

Beta Thalassemia is one of the most common global health concerns worldwide. It affects a large population in Pakistan, too, thereby increasing the financial burden. Several screening procedures have been proposed to lessen the cost burden associated with Beta Thalassemia. This study focuses on studying the occurrence of beta-thalassemia trait among pregnant ladies, the commonest mutations among Beta Thalassemia Trait cases, and defining the hematological parameters to overcome this expensive burden.Blood was collected via venipuncture to carry-out CBC (Complete Blood Count) and H.B. (Hemoglobin) Electrophoresis is used to detect beta-thalassemia minor. In this study, the main CBC parameters to screen BTT included MCV (≤75fl), MCH (≤25pg), RBCs (≥4.50 million), and Hemoglobin (≤12g/Dl), whereas Hb electrophoresis confirmed the final diagnosis. The cut-off values for the final confirmation of BTT through Hb electrophoresis were &#62;3.5% HBA2 and &#60;95% HBA. Statistical tests used during the study included Mean and Standard deviation. Tetra-arm multiplex PCR was carried out to detect mutations. Thalassemia minor was detected in 15 out of 509 conceiving females present in our study cohort, thus overall incidence rate being 2.9%. Moreover, the most reliable parameters for screening beta-thalassemia minor included MCV, MCH, RBCs, and RDW. Iron Deficiency Anemia (IDA) didn't hinder the accurate diagnosis of the beta-thalassemia minor. Moreover, our data revealed the IVS 1-5(G-C) (4 samples) and FSc 8-9 (+G) (4 samples) to be the commonest mutations among carrier females. However, CD 30 mutation was found in 2 samples. However, Primers were designed for the most commonly reported mutations in Pakistan including F.Sc 8/9, IVS 1- 5, 619bp deletion, CD 16, and CD 30. Extensive screening strategies and detailed genetic counselling are needed to identify the risk and genetic epidemiology of Beta Thalassemia in Pakistan.
Adverse pregnancy outcome in low PAPP-A levels: First trimester screening hospital based study
Authors: Jindal Ankur , Polipalli Sunil Kumar , Kapoor Seema , Mishra Ranjana 
Published: October 2023

To assess the adverse pregnancy outcome in Low Pregnancy Associated Plasma Protein -A (PAPP-A) levels in serum.This is a prospective cohort study, which included 2150 pregnant women who attended the antenatal clinic of Obstetrics and Gynecology in the Lok Nayak Hospital, New Delhi, India. Blood samples were collected by the venipuncture method for First trimester screening to assess free β-hCG and PAPP-A concentrations were measured by Auto DELFIA (Perkin Elmer, Turku, Finland).In this study a total of 210 women who have the low PAPP-A value less than 0.4 MoM were under the closer surveillance for serious pregnancy outcome. 33(15.6%) women had pre-eclempsia, 27 (12.9%) cases showed intra-utrine growth retardation (IUGR), 6 (3.0%) cases have intra-utrine death. 48 (22.8%) women have pregnancy induced hypertension, and 96(45.6%) cases have other pregnancy related complication. Low PAPP-A levels gives an indication of adverse pregnancy outcome in the early gestation age during the first trimester.
Kepuasan penumpang pada terminal bus di kawasan Pondok Cabe
Authors: Komarrudin Achmad , Handayani Susanty , Suryobuwono Abdullah Ade , Ricardianto Prasadja , Abdurachman Edi 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pengaruh kualitas pelayanan dan aksesibilitas terminal terhadap kepuasan penumpang, pengaruh kualitas pelayanan, aksesibilitas terminal dan kepuasan penumpang terhadap loyalitas penumpang serta pengaruh tidak langsung kualitas pelayanan dan aksesibilitas terminal terhadap loyalitas penumpang melalui kepuasan penumpang pada terminal Pondok Cabe. Sampel penelitian ini sebanyak 200 responden yang merupakan pengguna jasa terminal Pondok Cabe. Teknik pengumpulan data menggunakan kuesioner online. Metode analisis data yang digunakan adalah analisis jalur serta uji sobel. Dari Penelitian ini dapat disimpulkan bahwa loyalitas penumpang dipengaruhi oleh kualitas pelayanan dan kepuasan penumpang sebagai variabel intervening dan tidak dipengaruhi oleh aksesiblitas terminal, pada hasil penelitian menunjukan bahwa kualitas pelayanan dan aksesibilitas terminal berpengaruh positif dan signifikan terhadap kepuasan penumpang serta kualitas pelayanan dan kepuasan penumpang berpengaruh positif dan signifikan terhadap loyalitas penumpang. Kepuasan pelanggan dapat memediasi pengaruh kualitas layanan dan aksesibilitas terminal terhadap loyalitas pelanggan.