bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methylprednisolone pulse-enhanced neutrophil extracellular trap formation in mice with imiquimod-induced lupus-like disease, resulting in ischaemia of the femoral head cartilage
Authors: Ogawa Hodaka , Yokota Shunichi , Hosoi Yumeka , Shindo Ayano , Ogawa Naho , Yamamura Ryodai , Shimizu Tomohiro , Nakade Issei , Arai Suishin , Taniguchi Mai , Nishibata Yuka , Masuda Sakiko , Nakazawa Daigo , Tomaru Utano , Iwasaki Norimasa , Ishizu Akihiro 
Published: December 2023

ObjectivesMethylprednisolone (mPSL) pulse therapy is an essential option for patients with active systemic lupus erythematosus, but there is a risk of adverse events related to microcirculation disorders, including idiopathic osteonecrosis of the femoral head (ONFH). Recent studies have revealed that excessive neutrophil extracellular traps (NETs) are involved in microcirculation disorders. This study aimed to demonstrate that mPSL pulse could induce NETs in lupus mice and identify the factors contributing to this induction.MethodsSix mice with imiquimod (IMQ)-induced lupus-like disease and six normal mice were intraperitoneally injected with mPSL on days 39 to 41, and five mice with IMQ-induced lupus-like disease and six normal mice were injected with phosphate-buffered saline. Pathological examinations were conducted to evaluate the ischaemic state of the femoral head and tissue infiltration of NET-forming neutrophils. Proteome analysis was performed to extract plasma proteins specifically elevated in mPSL-administered mice with IMQ-induced lupus-like disease, and their effects on NET formation were assessed in vitro.ResultsMice with IMQ-induced lupus-like disease that received mPSL pulse demonstrated ischaemia of the femoral head cartilage with tissue infiltration of NET-forming neutrophils. Proteome analysis suggested that prenylcysteine oxidase 1 (PCYOX1) played a role in this phenomenon. The reaction of PCYOX1-containing very low-density lipoproteins (VLDL) with its substrate farnesylcysteine (FC) induced NETs in vitro. The combined addition of IMQ and mPSL synergistically enhanced VLDL-plus-FC-induced NET formation.ConclusionPCYOX1 and related factors are worthy of attention to understand the underlying mechanisms and create novel therapeutic strategies for mPSL-mediated microcirculation disorders, including ONFH.
Clinical significance of exostosin 1 in confirmed and suspected lupus membranous nephropathy
Authors: Ye Tian , Jiang Mengya , Zeng Xueyan , Zong Dan , Du Yuanyuan , Li Xiaohong , Huang Biao , Tang Xuanli 
Published: December 2023

ObjectiveThis study aimed to investigate the clinical significance of exostosin 1 (EXT1) in confirmed and suspected lupus membranous nephropathy (LMN).MethodsEXT1 was detected in 67 renal tissues of M-type phospholipase A2 receptor (PLA2R)-negative and ANA-positive membranous nephropathy by immunohistochemistry, and cases were divided into confirmed LMN and suspected LMN. The clinicopathological data were compared among the above groups, as well as EXT1-positive group and EXT1-negative group.ResultsTwenty-two cases (73.3%) of confirmed LMN and six cases (16.2%) of suspected LMN exhibited EXT1 expression on the glomerular basement membrane and/or mesangium area, showing a significant difference (p<0.001). Concurrently, lupus nephritis (LN) of pure class V demonstrated a lower frequency of EXT1 positivity compared with mixed class V LN in the confirmed LMN group (31.8% vs 68.2%, p=0.007). EXT1-positive patients in the confirmed and suspected LMN group showed significant differences in some clinicopathological data comparing with EXT1-negative patients (p<0.05). Follow-up data revealed that a greater proportion of patients in the EXT1-positive group achieved complete remission post-treatment (p<0.05). Cox regression analysis showed that EXT1 positivity was significantly correlated with complete remission across the entire study cohort (HR 5.647; 95% CI, 1.323 to 12.048; p=0.019). Kaplan-Meier analysis indicated that the EXT1-positive group had a higher rate of accumulated nephrotic remission compared with the EXT1-negative group in the whole study cohort (p=0.028).ConclusionsThe EXT1-positive group exhibited a higher active index and a more favourable renal outcome than the EXT1-negative group. It would be better to recognise suspected LMN with EXT1 positivity as a potential autoimmune disease and maintain close follow-up due to its similarities with confirmed LMN.
Psychometric properties, predictive utility and diagnostic capacity of the Persian version of the Scale of Resilience to Suicide Attempts in army conscripts
Authors: Rashtbari Alireza , Rahnejat AM , Taghva A , Jamil L , Sheykholeslami A 
Published: December 2023

IntroductionSuicide among army conscripts represents a poorly understood and complex public health issue that has escalated in recent decades. The early identification of individuals at risk holds the potential to significantly contribute to the effective prevention of suicide attempts. To address this, the Scale of Resilience to Suicide Attempts-18 (SRSA-18) has been developed to assess protective factors related to suicide attempts. The present study aimed to develop a Persian version of SRSA-18 (P-SRSA) and examine its psychometric properties and predictive utility within a sample of the Iranian Army.MethodsThe initial study sample consisted of 400 male conscripts from the Iranian Army grand forces (M=19.86, SD=1.40). Subsequently, for the follow-up stage, 296 participants (M=19.83, SD=1.39) were recruited. The participants were assessed using various measures of resilience, social support, suicide and hopelessness at baseline and a 6-month follow-up.ResultsIn contrast to the original version, both exploratory and confirmatory factor analyses supported an 18-item two-factor model of the P-SRSA (root mean square error of approximation=0.076; 95% CI (0.069 to 0.086), comparative fit index=0.943, Tucker-Lewis index=0.936). P-SRSA strongly correlated with convergent/divergent measures and demonstrated satisfactory internal consistency (α=0.82). Furthermore, regression analysis revealed that the P-SRSA significantly predicted suicide reattempts at baseline and during a 6-month follow-up period.ConclusionThe study confirms that the P-SRSA, comprising a two-factor, 18-item solution, is a reliable measure of resilience, displaying robust discriminant and predictive validity. These findings provide substantial support for implementing P-SRSA in samples from the Iranian Army, highlighting its potential to identify suicidal conscripts effectively.
High-temperature superconductivity mechanism and an alternative theoretical model of Maxwell’s classical electromagnetism theory
Authors: Fan Wei 
Published: December 2023

In the 21st century, understanding the mechanism of high-temperature superconductivity has emerged as a pinnacle achievement in condensed matter physics, capturing the lifelong interest of numerous physicists. This paper endeavors to offer a theoretical elucidation for this mechanism, advancing the broader field of physics. Recognizing that high-temperature superconductivity is an aspect of condensed matter physics — underpinned by Maxwell’s classical electromagnetic theory — we turn to theoretical mechanics and field theory, which are foundational perspectives in the contemporary scientific era. By framing Maxwell’s classical electromagnetic theory within the context of theoretical mechanics and field theory, this paper not only sheds light on the mechanism of high-temperature superconductivity but also recasts Maxwell’s theory within a purer theoretical mechanics and field theory domain. This represents a paradigmatic shift and cognitive transformation in physics. Furthermore, leveraging this theoretical mechanics and field theory interpretation of electromagnetic phenomena, we discern that electromagnetic phenomena can be more aptly explained without resorting to the concepts of charges and electric fields, leading to a reinterpretation of Coulomb’s law. We propose that protons and electrons might exist as entities devoid of charge-specific attributes and negate the possibility of a strongly correlated particle system within them.
Agonist Antibodies for Cancer Immunotherapy: History, Hopes, and Challenges
Authors: Lim Sean H. , Beers Stephen A. , Al-Shamkhani Aymen , Cragg Mark S. 
Published: December 2023

Abstract
Immunotherapy is among the most promising new treatment modalities to arise over the last two decades; antibody drugs are delivering immunotherapy to millions of patients with many different types of cancer. Initial success with antibody therapeutics came in the form of direct targeting or cytotoxic antibodies, such as rituximab and trastuzumab, which bind directly to tumor cells to elicit their destruction. These were followed by immunomodulatory antibodies that elicit antitumor responses by either stimulating immune cells or relieving tumor-mediated suppression. By far the most successful approach in the clinic to date has been relieving immune suppression, with immune checkpoint blockade now a standard approach in the treatment of many cancer types. Despite equivalent and sometimes even more impressive effects in preclinical models, agonist antibodies designed to stimulate the immune system have lagged behind in their clinical translation. In this review, we document the main receptors that have been targeted by agonist antibodies, consider the various approaches that have been evaluated to date, detail what we have learned, and consider how their anticancer potential can be unlocked.
Cardiovascular Complications in Pheochromocytoma and Paraganglioma: Does Phenotype Matter?
Authors: Petrák Ondřej , Krátká Zuzana , Holaj Robert , Zítek Matěj , Nguyen Nikrýnová Thi , Klímová Judita , Kološová Barbora , Waldauf Petr , Michalský David , Novák Květoslav , Markvartová Alice , Zlatohlávek Lukáš , Grus Tomáš , Dušková Jaroslava , Widimský Jiří , Zelinka Tomáš 
Published: December 2023

BACKGROUND:
Adrenaline-producing tumors are mostly characterized by a sudden release of catecholamines with episodic symptoms. Noradrenergic ones are usually less symptomatic and characterized by a continuous overproduction of catecholamines that are released into the bloodstream. Their effects on the cardiovascular system can thus be different. The aim of this study was to determine the prevalence of cardiovascular complications by catecholamine phenotype.

METHODS:
We retrospectively analyzed data on the prevalence of cardiovascular events in 341 consecutive patients with pheochromocytoma and paraganglioma treated from 1995 to 2023. Biochemical catecholamine phenotype was determined based on plasma or urinary catecholamines and metanephrines.

RESULTS:

According to the phenotype, 153 patients had noradrenergic pheochromocytoma and paraganglioma and 188 had adrenergic pheochromocytoma and paraganglioma. In the whole sample, the incidence of serious cardiovascular complications was 28% (95 patients), with no difference between the phenotypes or sexes. The noradrenergic phenotype had significantly more atherosclerotic complications (composite end point of type 1 myocardial infarction and symptomatic peripheral artery disease; odds ratio, 3.58 [95% CI, 1.59–8.83];
P
=0.003), while the adrenergic phenotype more often had type 2 myocardial infarction and takotsubo-like cardiomyopathy (OR, 0.24 [95% CI, 0.09–0.57];
P
=0.002). These changes remained even after adjustment for conventional risk factors of atherosclerosis.

CONCLUSIONS:
We found a 28% incidence of cardiovascular complications in a consecutive group of patients with pheochromocytoma and paraganglioma. Patients presenting with a noradrenergic phenotype have a higher incidence of atherosclerotic complications, while the adrenergic phenotype is associated with a higher incidence of acute myocardial damage due to takotsubo-like cardiomyopathy.
Transradial Access Versus Transfemoral Approach for Carotid Artery Stenting: A Systematic Review and Meta‐Analysis
Authors: Rodriguez‐Calienes Aaron , Chavez‐Ecos Fabian A. , Espinosa‐Martinez David , Bustamante‐Paytan Diego , Vivanco‐Suarez Juan , Borjas‐Calderón Nagheli Fernanda , Galecio‐Castillo Milagros , Morán‐Mariños Cristian , Guerrero Waldo R. , Ortega‐Gutierrez Santiago 
Published: December 2023

Background
Carotid artery stenting (CAS) has emerged as a viable alternative to carotid endarterectomy for managing carotid artery stenosis in high‐risk patients. Although transfemoral arterial access remains the preferred method, it is associated with inherent limitations and potential complications. Consequently, exploring transradial artery access as a potential option becomes crucial in optimizing patient outcomes and procedural success rates. There are limited data comparing the outcomes of the transradial with the transfemoral approach for CAS. This study aimed to systematically review and meta‐analyze the outcomes and complication rates between transradial and transfemoral access for CAS.

Methods
A systematic electronic search was conducted in 4 databases. Studies with randomized or nonrandomized designs, involving CAS by the transradial or transfemoral approach, were included. Outcomes of interest were stroke, transient ischemic attack, death, myocardial infarction, and access site complications. A meta‐analysis was performed, analyzing pooled odds ratios (ORs) and 95% CIs to assess the effect size.

Results

Six studies with a total of 6917 patients were included, of whom 602 (8.7%) underwent the transradial approach and 6315 (91.3%) the transfemoral approach. The meta‐analysis showed no significant difference in stroke occurrence between the transradial and transfemoral groups (transradial:1.7% versus transfemoral:1.9%; OR = 0.98 [95% CI, 0.49–1.96]; I
2
= 0%). Similarly, no significant difference was found in death (TR:1% versus transfemoral:0.9%; OR = 0.95 [95% CI, 0.38–2.37]; I
2
= 0%), myocardial infarction (transradial:0.2% versus transfemoral:0.3%; OR = 1.53 [95% CI, 0.20–11.61]; I
2
= 0%), transient ischemic attack (transradial:0.4% versus transfemoral:1%; OR = 0.46 [95% CI, 0.11–1.95]; I
2
= 0%), or access site complications (transradial:2.2% versus transfemoral:1%; OR = 0.97 [95% CI, 0.48–1.98]; I
2
= 0%).

Conclusion
No significant differences were observed in stroke, death, myocardial infarction, transient ischemic attack, or access site complications on comparing thetransradial and transfemoral approaches for CAS. The transradial approach shows promise as an alternative method for CAS, offering potential benefits without increased risk of complications. However, further studies are needed to confirm these findings.
Pragmatism as a Mediator – Seeking an Illusory Harmony?
Authors: Pihlström Sami 
Published: December 2023

Abstract
This paper examines the well-known pragmatist claim to mediate between philosophical disputes. While recognizing the reconciliatory and harmonizing role that pragmatism plays in traditional debates between, for example, realism and antirealism, naturalism and culturalism, or science and religion, it is argued that the pragmatist also needs to acknowledge that there are situations in which no such mediation is reasonably possible, such as the conflict between racism and antiracism. The metaphilosophical question to be raised is how – in terms of pragmatism itself – we are able to distinguish between these different cases and what exactly it means to apply the pragmatic method to resolving this meta-level issue. Pragmatism here emerges as a thoroughly fallible and antifoundationalist reflexive inquiry into what it means, and what it ought to mean, for us to view philosophical issues in terms of their conceivable practical consequences. The project of mediation must be subordinated to this more fundamental understanding of pragmatist methodology.
The Influence of Time-Varying Sea Ice Concentration on Antarctic and Southern Ocean Numerical Weather Prediction
Authors: Wang Zhaohui , Fraser Alexander D. , Reid Phil , Coleman Richard , O’Farrell Siobhan 
Published: December 2023

Abstract
Although operational weather forecasting centers are increasingly using global coupled atmosphere–ocean–ice models to replace atmosphere-only models for short- and medium-range (10 day) weather forecasting, the influence of sea ice on such forecasting has yet to be fully quantified, especially in the Southern Ocean. To address this gap, a polar-specific version of the Weather Research and Forecasting Model is implemented with a circumpolar Antarctic domain to investigate the impact of daily updates of sea ice concentration on short- and medium- range weather forecasting. A statistically significant improvement in near-surface atmospheric temperature and humidity is shown from +24 to +192 h when updating the daily sea ice concentration in the model. The forecast skill improvements for 2-m temperature and dewpoint temperature are enhanced from June to September, which is the period of late sea ice advance. Regionally, model improvement is shown to occur in most sea ice regions, although the improvement is strongest in the Ross Sea and Weddell Sea sectors. The surface heat budget also shows remarkable improvement in outgoing radiative heat fluxes and both sensible and latent heat fluxes. This idealized research demonstrates the nonnegligible effect of including more accurate time-varying sea ice concentration in numerical weather forecasting.

Significance Statement
The purpose of this study is to understand how a more realistic Antarctic sea ice field may influence the skill of short- and medium-range weather forecasts. Many operational atmospheric numerical weather prediction (NWP) models use a static forecast field through the time frame of the model’s forecast—often 3–10 days. In this study, we updated the sea ice concentration field daily and compared the forecast outcomes with those from model runs using a static sea ice concentration field. We found the forecast skill of near-surface temperature and humidity show the most significant improvements in our idealized experiments. This indicates the importance of incorporating improved dynamic sea ice representation in Antarctic short- to medium-range operational weather forecasting.
Parent Training Tailored to Parents With ADHD: Development of the Improving Parenting Skills Adult ADHD (IPSA) Program
Authors: Lindström Therese , Buddgård Sofia , Westholm Lena , Forster Martin , Bölte Sven , Hirvikoski Tatja 
Published: December 2023

Objective: To describe the development of the Improving Parenting Skills Adult ADHD (IPSA) parent training (PT) program, designed for parents with ADHD. Method: IPSA was developed using an iterative co-creation approach, involving parents with ADHD from the initial knowledge mobilization phase onwards. The program prototype was evaluated by 16 parents with ADHD, in an open trial of program feasibility. Results: IPSA was deemed feasible in terms of acceptability and levels of active participation, with no evidence of unintended harm. All but one participant completed the program, attending on average 84% of sessions. Pre-to-post within-group comparisons of targeted skills and outcomes revealed changes in the expected direction regarding, for example, use of introduced parenting skills (Cohen’s d = 1.3). Conclusion: The program prototype was found acceptable, accessible, and safe. Findings support the potential value of adapting PT protocols for parents with ADHD and warrant further evaluation of IPSA in a randomized controlled trial.
A longitudinal study of loneliness in autism and other neurodevelopmental disabilities: Coping with loneliness from childhood through adulthood
Authors: Schiltz Hillary , Gohari Dena , Park Jamie , Lord Catherine 
Published: December 2023

Many autistic people and people with non-spectrum neurodevelopmental disabilities (e.g. intellectual disability) report feeling lonely, which can negatively impact their well-being. There is little longitudinal research, however, tracking changes in how autistic people experience, conceptualize, and cope with loneliness throughout their lives. A longitudinal sample of 114 people, which included autistic participants and participants with neurodevelopmental disabilities, characterized experiences of loneliness, perceptions of other people’s loneliness, and strategies used to cope with loneliness from childhood to adulthood. Level of loneliness and coping strategies were coded from Autism Diagnostic Observation Schedule Modules 3 and 4 protocol forms. Autism Diagnostic Observation Schedule Loneliness Ratings were correlated across time and increased from adolescence to young adulthood. The most common loneliness coping strategies were Behavioral Distraction (e.g. watching TV) and Instrumental Action (e.g. seeking social contact), which were both used by more people in adulthood than childhood. Those who used Behavioral Distraction and a greater number of coping strategies had higher Autism Diagnostic Observation Schedule Loneliness–Self Ratings (i.e. were lonelier) during adolescence and adulthood. Findings highlight adulthood as a particularly vulnerable time for loneliness and indicate a need for more support and social opportunities for autistic adults and adults with neurodevelopmental disabilities who wish to make more social connections. Lay abstract We know that many autistic people feel lonely, but we don’t know whether their loneliness changes over time. Our research study followed autistic people and people with other non-spectrum neurodevelopmental disabilities from childhood through young adulthood and asked them about their loneliness. While many people told us they felt lonely or very lonely, a sizable group also told us that they do not feel lonely. We found that people who reported feeling lonely earlier in life were likely to also report feeling lonely later in life. Overall, autistic people and people with other neurodevelopmental disabilities in our study became lonelier from adolescence to adulthood. People described multiple ways they cope with feeling lonely, such as distracting themselves or reaching out to connect with another person. People who used distraction tended to be lonelier than those who did not. Our findings tell us that there is a need for greater support of social connections for many autistic people as they become adults.
Evaluation of solubility parameters and relative energy difference (RED) on the preparation of polysulfone/polyethylene glycol membrane: A study on the casting solution and coagulation bath
Authors: Dehghan Rahim , Kordkatooli Zahra , Barzin Jalal 
Published: December 2023

Solubility parameters are effective factors for controlling membrane preparation based on hydrophilic/hydrophobic polymers. Hansen solubility parameters (HSPs) of a polysulfone/polyethylene glycol (PSU/PEG) in increasing PEG molecular weights and binary coagulation bath of solvent/non-solvent mixtures are investigated. The results revealed that with increased PEG molecular weight in the casting solution, the relative energy difference (RED) of the solution increases, and subsequently its instability increases too. On the other hand, by increasing the solvent in the coagulation bath, RED decreases. Findings demonstrated that by increasing PEG molecular weight to 15,000 g/mol and increasing solvent to 60 wt% in the coagulation bath, an interconnected sponge-like structure with maximum mean pore size (120 nm) was achieved. With increased PEG molecular weight, membrane morphology tended toward to a sponge-like structure due to delayed demixing in the phase inversion stage. Furthermore, pure water permeability and rejection capability of membranes exhibited that with increasing RED of casting solution and reducing RED of coagulation bath, the highest permeability (2199 L/m2h and the lowest rejection capability (33%) of the membrane were attained. This study confirmed that, for the PSU/PEG system, by controlling the solubility parameters, RED value of casting solution and coagulation bath, membrane characteristics can be controlled.