bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 pandemic on healthcare delivery for lysosomal storage disorders at a tertiary care public hospital in Mumbai
Authors: Muranjan M , Karande S , Rajoria S 
Published: January 2024

ABSTRACT

Introduction:
Management of lysosomal storage disorders (LSDs) requires periodic visits for medical surveillance and hospitalizations. Management of LSDs may have been adversely impacted during the COVID-19 pandemic.

Objective:
To identify the factors impacting health care for patients with LSDs during the COVID-19 pandemic.

Methods:
An observational study was conducted in Mumbai comparing infusion practices and reasons for missed infusions for 15 months before March 2020 versus two phases during the pandemic (April 2020–March 2021 and April 2021–March 2022) in patients receiving intravenous enzyme replacement therapy (ERT) and on oral substrate reduction therapy (SRT).

Results:
Fifteen patients with LSDs were enrolled. Before the pandemic, 6/13 (46%) were receiving ERT at the study site, 4/13 (31%) at a local hospital, and 3/13 (23%) at home; two were on SRT. The median distance traveled for receiving ERT was 37 km, and 4.4 infusions/patient were missed. From April 2020 to March 2021, two more patients opted for home ERT infusions. The median distance traveled for receiving ERT was 37 km, and 11.6 infusions/patient were missed. From April 2021 to March 2022, one more patient opted for home ERT infusions. The median distance traveled for receiving ERT was 7 km, and 5.6 infusions/patient were missed. The pandemic also affected SRT compliance adversely. For all patients, the cause of disrupted treatment was travel curbs (69%) and fear of getting COVID-19 infection (38%).

Conclusions:
Treatment of LSDs was disrupted during the pandemic, with an increase in missed ERT infusions and SRT doses.
Aflibercept treatment for delayed retinotomy-associated choroidal neovascularization: A case report and literature review
Authors: Yeh Cyuan-Yi , Liang Yi-Ting , Cheng Cheng-Kuo 
Published: January 2024

Abstract:
A 67-year-old male presented to our clinic with sudden onset of blurred vision and metamorphopsia of his left eye for 2 weeks. He had a history of combined rhegmatogenous retinal detachment and vitreous hemorrhage and underwent an uneventful pars plana vitrectomy, 360° scleral buckling, and drainage retinotomy for his left eye 3 years ago. The anatomic and visual outcomes after surgery were good, without complications. On examination during this visit, an orange–red subretinal mass connected to the previous drainage retinotomy scar was noted. Spectral-domain optical coherence tomography revealed severe subretinal fluid with type-2 choroidal neovascularization (CNV) mass at the superior nasal macular area in connection with the margin of the previous retinotomy scar. Fundus fluorescein angiography showed an active CNV. The patient underwent monthly intravitreal aflibercept in the left eye. After four doses of aflibercept, his CNV regressed with no recurrence on follow-up at 20 months. In conclusion, iatrogenic CNV is a rare complication following uneventful vitreoretinal surgery and can develop years after the operation. It is crucial to early diagnose and treat it with intravitreal antivascular endothelial growth factor treatment for a favorable outcome and long-term remission.
Extraocular muscle bridle traction suture assisted Paul glaucoma implant surgery for severe conjunctival scarring
Authors: Shao Yi-Ching , Wang Lu-Chun , Lee Yi-An 
Published: January 2024

Abstract:
Glaucoma drainage device implantation can be complex and challenging, particularly in patients with conjunctival scarring. However, in this case, involving a young man with refractory glaucoma who had undergone multiple ocular surgeries, the implantation of a Paul glaucoma drainage device was successfully performed after the application of extraocular muscle bridle sutures. The patient exhibited a stable intraocular pressure ranging from 12 to 18 mmHg without antiglaucoma medication during the 3-month follow-up period. Thus, this surgical technique improves the accuracy and ease of inferior-temporal quadrant glaucoma drainage implantation, resulting in good treatment outcomes.
Bilateral optic neuritis and encephalopathy as the atypical presentations of multiple sclerosis following severe acute respiratory syndrome coronavirus 2 infection
Authors: Liu Sheng-Yu , Hsieh Wan-Jen , Hsueh Hsueh-Wen , Lin Chao-Wen 
Published: January 2024

Abstract
Numerous evidence suggests coronavirus disease 2019 (COVID-19) potentially triggers demyelinating diseases, inclusive of multiple sclerosis (MS), and acute disseminated encephalomyelitis (ADEM), and various mechanisms have been proposed. We report a 42-year-old male presented with bilateral optic neuritis and encephalopathy, 2 weeks following COVID-19 infection. He denied any history or family history of neurological and ocular diseases. Severe bilateral visual impairment (only light perception) and pain with eye movement were reported. Fundoscopy revealed bilateral optic disc swelling. Magnetic resonance imaging showed tortuous bilateral optic nerves with optic nerve and nerve sheath enhancement. Multiple hyperintense nodules in bilateral cerebral white matter were noted on fluid-attenuated inversion recovery T2-weighted imaging without diffusion restriction or gadolinium contrast enhancement. Hypointense nodules in cerebral white matter were also noted on T1-weighted imaging, which implied some old lesions. Dissemination in space and time and cerebrospinal fluid-specific oligoclonal bands confirmed the diagnosis of MS. Both serum aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies were negative. He received pulse steroid therapy for 5 days, followed by slowly tapering oral prednisolone. His vision, ocular motion pain, and encephalopathy improved gradually. However, the visual outcome was still poor (bilateral 20/400), and optic atrophy was noticed during 1-year follow-up. To our knowledge, this is the first case of MS following severe acute respiratory syndrome coronavirus 2 infection presented with bilateral optic neuritis and encephalopathy. Since these manifestations are exceedingly rare in MS, we suspect acute immune reactions induced by COVID-19 could bring about the atypical ADEM-like presentations of MS.
Experiences in Improving the Quality of Community-Based Fever Management from Three Malaria-Endemic African Countries
Authors: Ahmed Jehan , Nothem Adam , Mostel Jadmin , Ciceron Annie , Nuñez Luigi , Raobela Oméga , Raoiliarison Andry Patrick , Lankhulani Sosten , Munthali John , Cissoko Mady , Kamaté Beh , Yattara Oumar , Coumaré Samba , Wolf Katherine 
Published: January 2024

ABSTRACT.
The WHO affirms that trained, supervised, and supported community health workers (CHWs) can deliver high-quality health services effectively and has called for documentation of enabling factors, needs, and implementation strategies of successful CHW programs. In response, the U.S. President’s Malaria Initiative Impact Malaria Project conducted a study to document implementation approaches, best practices, and lessons learned for quality improvement (QI) of community-based fever management in Madagascar, Malawi, and Mali. The team conducted 10 key informant interviews (KIIs) with individuals at national, regional, and district levels using an open-ended interview guide tailored to each level, and a desk review of documents and materials related to community-based QI. Each country’s community health landscape and QI approaches were summarized into four categories identified during the KIIs (training, supervision, coaching/mentoring, and review meetings) and compared. Results found that Madagascar, Malawi, and Mali all had well-defined community health strategies that include QI, but countries could not extend their full package of community-based QI approaches to all CHWs as a result of limited human and financial resources. Vertical funding for health programs limits the scope and coverage of QI approaches, especially at the community level. Recommendations from key informants for strengthening community-based QI included integrating QI approaches to improve cost efficiency, to define roles and responsibilities more clearly, to engage communities and all health system levels in implementation, and to digitize QI tools. Increased financial and skilled human resources are needed for community-based QI activities to achieve their intended effect.
Examination of Diagnostic Performance of New IgG4 Rapid Test Compared with IgG- and IgG4-ELISAs to Investigate Epidemiology of Strongyloidiasis in Northeast Thailand
Authors: Wongphutorn Phattharaphon , Noordin Rahmah , Anuar Nor Suhada , Worasith Chanika , Kopolrat Kulthida Y. , Homwong Chutima , Tippayawat Patcharaporn , Techasen Anchalee , Pitaksakurat Opal , Sithithaworn Jiraporn , Eamudomkarn Chatanun , Sithithaworn Paiboon 
Published: January 2024

ABSTRACT.
Strongyloidiasis, caused by Strongyloides stercoralis, is a neglected tropical disease with a global distribution. The infection can be fatal in immunocompromised individuals, and accurate diagnosis leading to timely treatment can save lives. Serodiagnosis is a sensitive method for diagnosis and is recommended for screening high-risk individuals. A point-of-care rapid test will facilitate the screening activities, especially in low-resource settings. This study aims to apply a new IgG4 immunochromatographic test using S. stercoralis recombinant antigen (SsRapid® cassette test) and to compare it with in-house IgG and IgG4 enzyme-linked immunosorbent assays (IgG- and IgG4-ELISAs) using native Strongyloides ratti antigen to investigate the epidemiology of strongyloidiasis in northeast Thailand. A total of 300 people participated, with 136 males and 164 females of a similar mean age. The reference tests were fecal examinations using the formalin-ethyl acetate concentration technique and an agar plate culture technique. The prevalence of S. stercoralis determined by SsRapid (81.7%) was significantly higher than that by fecal examinations (43.3%) or by antibody detection by IgG-ELISA (53.0%) or IgG4-ELISA (44.0%). The diagnostic sensitivities of SsRapid, IgG-ELISA, and IgG4-ELISA were found to be 93.9%, 77.7%, and 63.1%, respectively. The rate of positive tests by the SsRapid was significantly correlated to the levels of Strongyloides-specific IgG4 and IgG antibodies. By all diagnostic methods, male participants had a significantly higher prevalence of strongyloidiasis than females. Age was significantly associated with the concentration of specific serum IgG but not with the SsRapid grading score. In conclusion, SsRapid was shown to be a sensitive and valuable diagnostic test for the epidemiology study of strongyloidiasis.
Application of an ARFIMA Model to Estimate Hepatitis C Epidemics in Henan, China
Authors: Wang Yongbin , Liang Ziyue , Qing Siyu , Liu Xingyan , Xu Chunjie 
Published: January 2024

ABSTRACT.
Hepatitis C (HC) presents a substantial burden, and a goal has been established for ending HC epidemics by 2030. This study aimed to monitor HC epidemics by designing a paradigmatic autoregressive fractionally integrated moving average (ARFIMA) for projections until 2030, and evaluating its efficacy compared with the autoregressive integrated moving average (ARIMA). Monthly HC incidence data in Henan from January 2004 to June 2023 were obtained. Two periods (January 2004 to June 2022 and January 2004 to December 2015) were treated as training sets to build both models, whereas the remaining periods served as test sets to perform performance evaluation. There were 465,196 HC cases, with an escalation in incidence (average annual percentage change = 8.64, 95% CI: 3.71–13.80) and a peak in March and a trough in February. For both the 12 and 90 holdout data forecasts, ARFIMA generated lower errors than ARIMA across various metrics: mean absolute deviation (252.93 versus 262.28 and 235.37 versus 1,689.65), mean absolute percentage error (0.17 versus 0.18 and 0.14 versus 0.87), root mean square error (350.31 versus 362.31 and 311.96 versus 1,905.71), mean error rate (0.14 versus 0.15 and 0.11 versus 0.82), and root mean square percentage error (0.26 versus 0.26 and 0.24 versus 1.01). Autoregressive fractionally integrated moving average predicted 181,650 (95% CI: 46,518–316,783) HC cases, averaging 22,706 (95% CI: 5,815–39,598) cases annually during 2023–2030. Henan faces challenges in eliminating HC epidemics, emphasizing the need for strengthened strategies. Autoregressive fractionally integrated moving average can offer evidence-based insights for public health measures.
Pengaruh Pendidikan Kesehatan Terhadap Pengetahuan Ibu Hamil Tentang Pencegahan Penularan HIV dari Ibu ke Anak (PPIA)
Authors: Triana Hani , Purnasari Henni 
Published: January 2024

Lebih dari 90% kasus penularan HIV pada anak dan bayi ditularkan dari ibu secara vertikal pada saat kehamilan. Salah satu upaya untuk mencegah penularan dari ibu ke bayi dengan program Pencegahan Penularan HIV Dari Ibu Ke Anak (PPIA). Pencegahan Penularan HIV dari Ibu ke Anak (PPIA) terintegrasi dengan layanan KIA. Salah satu metode yang diterapkan dalam penanggulangan HIV-AIDS adalah pendidikan kesehatan. Pendidikan kesehatan membantu meningkatkan pengetahuan tentang HIV sehingga dapat mencegah penularan dari ibu ke anak. Tujuan penelitian ini adalah untuk meningkatkan pengetahuan ibu mengenai pencegahan penularan HIV dari ibu ke anak (PPIA). Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian pre-eksperimental dengan rancangan one grup pre test – posttest. Populasi dan sampel dalam penelitian ini adalah ibu hamil yang melakukan ANC yaitu sebanyak 84 orang dengan teknik pengambilan sampel menggunakan accidental sampling. Alat ukur pengumpulan data yang digunakan dalam penelitian ini adalah kuesioner. Dari hasil analisis data menunjukkan bahwa tingkat pengetahuan responden sebelum dilakukan pendidikan kesehatan dibandingkan dengan setelah dilakukan pendidikan kesehatan terjadi peningkatan pengetahuan. Hasil uji Wilcoxon Match Pairs Test menunjukkan hasil Z sebesar -7.318 dengan tingkat signifikan α sebesar 0,000 (2- tailed) (atau p value = 0,000 < 0,05) maka H1 diterima. Simpulan penelitian ini menunjukkan ada perbedaan yang signifikan pada pengetahuan ibu hamil tentang PPIA sebelum dan sesudah diberi pendidikan kesehatan.
Delimitación de la cobertura de manglar en el municipio de Tuxpan, Veracruz
Authors: Limón-Salvador Francisco , González-Mendoza América , López-Loyde Martha Fabiola 
Published: January 2024

Los manglares, vitales ecosistemas en México, destacan por su biodiversidad y servicios ecosistémicos. Debido a su extensión y dificultad de acceso, la percepción remota y los Sistemas de Información Geográfica facilitan su estudio a escala de paisaje. Con el objetivo de delimitar y estimar el área que ocupa el manglar en Tuxpan, Veracruz, el presente estudio usó imágenes de satélite de alta resolución del servicio PlanetScope. La escena se procesó con el software ENVI v5.3, previo al análisis, la imagen se trabajó con una corrección atmosférica, ortorrectificada y en proyección cartográfica. Se realizó un análisis de clasificación supervisado usando el algoritmo de máxima verosimilitud. El ecosistema de manglar en Tuxpan se reporta con una superficie de 47.8 km2, lo cual representa el 5% de extensión relativo al tamaño del municipio. Esta investigación ofrece mayor detalle sobre la extensión de los manglares de Tuxpan y sirve como base para estudios que comparen los cambios de cobertura de manglar a través del tiempo, así como para proyectos de restauración y conservación de los manglares.
Improvement of meat product traceability system using digital technologies
Authors: Serikkyzy M. S. , Balev D. K. , Vlahova-Vangelova D. B. 
Published: January 2024

This research work addresses the issue of enhancing the effectiveness of the meat product traceability system using modern digital technologies. In the context of increasing demand for food safety and minimizing risks to consumer health, ensuring accurate and reliable traceability of the origin, production conditions, and storage of meat products has become a crucial aspect. The aim of the study is to create an integration between the meat product traceability system and contemporary digital technologies. During the work, an analysis of existing problems and shortcomings in the current traceability system is planned, as well as an exploration of experiences from other industries where digital technologies have been successfully implemented to ensure transparency and data authenticity. In analyzing technological risks, all possible types of threats were considered. The sources of danger include incoming raw materials, the technological line of semi-smoked sausages, and their storage. The use of digital technologies allows for continuous data monitoring using Wi-Fi, combined thermometers, and quality logs. It is anticipated that the implementation of such a system will significantly reduce risks, improve product tracking, and enhance consumer trust in the quality and safety of meat products. The outcomes of this research will be valuable for food industry enterprises, regulatory bodies, and the scientific community that are striving to improve the control and traceability system of food products, utilizing cutting-edge digital innovations.
Study of the yield of dry substances during extraction of grape seeds and flax seeds
Authors: Tastemirova U. U. , Mukhtarkhanova R. B. , Singisov A. U. 
Published: January 2024

The extraction process is one of the most widely used methods in the food industry for obtaining biologically active substances necessary for fortifying food products. The purpose of this work is to study the influence of temperature, extraction duration and the content of plant materials (grape seeds and flax seeds) in the extractant on the yield of dry substances. The influence of the duration of the extraction process on the yield of has been established dry substances: for grape seeds 70 minutes, for flax seeds 65 minutes. Research has proven that the optimal content of flax seeds and grape seeds in the extractant is 12 % by weight of the extractant, and the extraction temperature is 400 ℃. The use of low-frequency ultrasonic technology in conjunction with vacuum allows us to obtain the maximum yield of dry substances from the composition of plant raw materials. For the products studied, the maximum yield of dry substances was 17.5 %. According to the results of the study, the recommended technological mode for low-frequency vacuum-ultrasonic extraction of a combined solution: 50% grape seed and 50 % flax seeds is: vibration frequency 22 kHz, ultrasound power 0.3 kW, residual pressure 0.09 MPa and exposure duration 15 minutes.
The effect of oleogel amounts on microbiological and organoleptic parameters of semi-smoked sausage
Authors: Igenbayev А. К. , Аmirkhanov Sh. А. , Ospankulova G. H. , Temirova I. J. , Aldiyeva A. B. , Salykova D. A. , Kardenov S. A. 
Published: January 2024

Since 2021, research has been conducted on the effect of various amounts of three-component oleogel, introduced as a substitute for animal fats, on the microbiological and organoleptic parameters of semi-smoked sausages. The aim of the study was to study the effect of three-component oleogel introduced in amounts of 7 % and 10 % on microbiological and organoleptic parameters of sausage products in comparison with control samples anddepending on storage conditions. The study was conducted 12 days after the date of manufacture in accordance with the storage conditions of the semi-smoked sausage technology. In terms of organoleptic parameters, the prototypes were not inferior to the control sample. On the contrary, they showed good results in juiciness, taste, appearance, smell and color. Semi-smoked sausages were dried according to the modes in a special laboratory apparatus (special cabinet SS 107 - meat) at a temperature of 12 °C and a relative humidity of 72 %. Microbiological indicators showed that the samples of sausages stored for 12 days did not contain E. coliform bacteria, S.aureus, sulfite-reducing clostridium, listeria (L. Monocytogenes), pathogenic microorganisms, including salmonella. Thus, the introduction of three-component oleogel into the composition of sausages does not have a negative effect on microbiological indicators.
Patients with glenohumeral arthritis are more likely to be prescribed opioids in the emergency department or urgent care setting
Authors: Gorbaty Jacob , Wally Meghan K. , Odum Susan , Yu Ziqing , Hamid Nady , Hsu Joseph R. , Beuhler Michael , Bosse Michael , Gibbs Michael , Griggs Christopher , Jarrett Steven , Karunakar Madhav , Kempton Laurence , Leas Daniel , Phelps Kevin , Roomian Tamar , Runyon Michael , Saha Animita , Sims Stephen , Watling Brad , Wyatt Stephen , Seymour Rachel 
Published: January 2024

Objective: The objective is to quantify the rate of opioid and benzodiazepine prescribing for the diagnosis of shoulder osteoarthritis across a large healthcare system and to describe the impact of a clinical decision support intervention on prescribing patterns.
Design: A prospective observational study.
Setting: One large healthcare system.
Patients and participants: Adult patients presenting with shoulder osteoarthritis.
Interventions: A clinical decision support intervention that presents an alert to prescribers when patients meet criteria for increased risk of opioid use disorder.
Main outcome measure: The percentage of patients receiving an opioid or benzodiazepine, the percentage who had at least one risk factor for misuse, and the percent of encounters in which the prescribing decision was influenced by the alert were the main outcome measures.
Results: A total of 5,380 outpatient encounters with a diagnosis of shoulder osteoarthritis were included. Twenty-nine percent (n = 1,548) of these encounters resulted in an opioid or benzodiazepine prescription. One-third of those who received a prescription had at least one risk factor for prescription misuse. Patients were more likely to receive opioids from the emergency department or urgent care facilities (40 percent of encounters) compared to outpatient facilities (28 percent) (p < .0001). Forty-four percent of the opioid prescriptions were for “potent opioids” (morphine milliequivalent conversion factor > 1). Of the 612 encounters triggering an alert, the prescribing decision was influenced (modified or not prescribed) in 53 encounters (8.7 percent). All but four (0.65 percent) of these encounters resulted in an opioid prescription.
Conclusion: Despite evidence against routine opioid use for osteoarthritis, one-third of patients with a primary diagnosis of glenohumeral osteoarthritis received an opioid prescription. Of those who received a prescription, over one-third had a risk factor for opioid misuse. An electronic clinic decision support tool influenced the prescription in less than 10 percent of encounters.
Penanganan Sampah Dalam Menciptakan Lingkungan Bersih Dan Sehat Di Desa Kunjorowesi Kab. Mojokerto
Authors: Muhammad Romli  , Ficky Raja Dirgantara Daulay  
Published: January 2024

Abstrak
Sampah sekarang tidak hanya permasalahan lingkungan dan masyarakat perkotaan saja tetapi sudah mulai merambah ke area pedesaan yang hingga kini belum ada solusinya. Hal ini terjadi di dusun Sekantong desa Kunjorowesi kec. Ngoro Mojokerto. Desa ini belum memiliki sistem dan sarana prasarana dalam penanganan sampah. Adapun kegiatan ini dimulai dari tanggal 21 Februari-21 Maret 2023. Dalam pengabdian ini menggunakan metode Participatory Action Research( PAR). Berdasarkan uraian dan hasil pembahasan kegiatan pengabdian menggunakan metode PAR, dapat disimpulkan bahwa kegiatan pengabdian di dusun Sekantong desa Kunjorowesi berjalan dengan baik mulai dari pemetaan masalah yang dibantu masyarakat, berdialog langsung dengan warga dan perangkat desa, sosialisasi sistem penanganan sampah dan realisasi tempat pembuangan sampah. Tujuan dari pengabdian ini supaya masyarakat dusun Sekantong memahami akan pentingnya penanganan sampah dalam menciptakan lingkungan yang bersih dan sehat.