bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autoantibodies against eukaryotic translation elongation factor 1 delta in two patients with autoimmune cerebellar ataxia
Authors: Guo Liyuan , Ren Haitao , Fan Siyuan , Chao Xingchen , Liu Mange , Guan Hongzhi , Wang Jing 
Published: January 2024

BackgroundAutoantibodies are useful biomarkers for the early detection and diagnosis of autoimmune cerebellar ataxia (ACA).ObjectiveTo identify novel autoantibody candidates in ACA patients.MethodsPatients with cerebellar ataxia of unknown cause were recruited from July 2018 to February 2023. Anti-neural autoantibodies in patient samples were detected by tissue-based indirect immunofluorescence assay (TBA) on rat cerebellum sections. TBA-positive samples were further screened for well-established anti-neural autoantibodies using commercial kits. Tissue-immunoprecipitation (TIP) and subsequent mass spectrometric (MS) analysis were used to explore the target antigens of autoantibodies in samples that were TBA-positive but negative for known autoantibodies. The specific binding between autoantibodies and the identified target antigen was confirmed by neutralization experiments, recombinant cell-based indirect immunofluorescence assay (CBA), and western blotting experiments.ResultsThe eukaryotic translation elongation factor 1 delta (EEF1D) protein was identified as a target antigen of autoantibodies in samples from a 43-year-old female ACA patient, while the specific binding of autoantibodies and EEF1D was confirmed by subsequent experiments. A second anti-EEF1D autoantibody-positive ACA patient, a 59-year-old female, was detected in simultaneous screening. The main clinical manifestations in each of the two patients were cerebellar syndrome, such as unsteady walking and limb ataxia. Both patients received immunotherapy, including corticosteroids, intravenous immunoglobulin, and mycophenolate mofetil. Their outcomes provided evidence to support the effectiveness of immunotherapy, but the cerebellar atrophy that occurred before treatment may be irreversible.ConclusionIn the current study, we identified anti-EEF1D autoantibody as a novel autoantibody candidate in ACA. Its pathological roles and diagnostic value need to be further verified in larger-scale studies.
Causal associations between gut microbiota and Cholestatic liver diseases: a Mendelian randomization study
Authors: Yang Jiaqi , Ma Gang , Wang Kemei , Yang Hui , Jiang Shuangshuang , Fan Qingling , Zhou Xinmin , Guo Guanya , Han Ying 
Published: January 2024

BackgroundThe etiological factors of Cholestatic Liver Diseases especially primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are not fully illustrated. It has been reported in previous observational studies that gut microbiota are associated with cholestatic liver diseases. However, there is uncertainty regarding the causality of this association. By using Mendelian randomization, this study aimed to examine the causal impact of gut microbiota on cholestatic liver diseases.MethodsFrom large-scale genome-wide association studies, genetic instruments for each gut microbiota taxa as well as primary biliary cholangitis and primary sclerosing cholangitis were developed. Subsequently, we conducted a two-sample Mendelian randomization analysis, supplemented by multiple post hoc sensitivity analyses. Additionally, we performed reverse MR analyses to investigate the possibility of the reverse causal association.ResultThis two-sample MR study indicated that the order Bacillales, family Peptostreptococcaceae, family Ruminococcaceae, genus Anaerotruncu was associated with a decreased risk of developing PBC, and that order Selenomonadales, family Bifidobacteriaceae may be factors that increase the risk of PBC. On the other hand, we also identified order Selenomonadales, family Rhodospirillaceae, and genus RuminococcaceaeUCG013 were positively associated with PSC. The order Actinomycetales, family Actinomycetaceae, genus Actinomyces, genus Alloprevotella, genus Barnesiella, and genus Peptococcus were found negative associations with the risk of PSC. The reverse MR analysis demonstrated no statistically significant relationship between PBC, PSC and these specific gut microbial taxa.ConclusionOur findings offered novel evidence that the abundance of particular bacteria contributes to the risk of PBC and PSC, which may contribute to more effective approaches to PBC and PSC therapy and prevention.
Through the wall human heart beat detection using single channel CW radar
Authors: Pramanik Sourav Kumar , Islam Shekh Md Mahmudul 
Published: January 2024

Single-channel continuous wave (CW) radar is widely used and has gained popularity due to its simple architecture despite its inability to measure the range and angular location of the target. Its popularity arises in the industry due to the simplicity of the required components, the low demands on the sampling rate, and their low costs. Through-the-wall life signs detection using microwave Doppler Radar is an active area of research and investigation. Most of the work in the literature focused on utilizing multi-channel frequency modulated continuous wave (FMCW), CW, and ultra-wideband (UWB) radar for their capability of range and direction of arrival (DOA) estimation. In this paper, through-the-wall single-subject and two-subject concurrent heart rate detection using single-channel 24-GHz CW radar leveraged with maximal overlap discrete wavelet transform (MODWT) is proposed. Experimental results demonstrated that the repetitive measurement of seven different subjects at a distance of 20 cm up to 100 cm through two different barriers (wood and brick wall) showed an average accuracy of heart rate extraction of 95.27% for varied distances (20–100 cm) in comparison with the Biopac ECG acquisition signal. Additionally, the MODWT method can also isolate the independent heartbeat waveforms from the two subjects’ concurrent measurements through the wall. This involved four trials with eight different subjects, achieving an accuracy of 97.04% for a fixed distance of 40 cm from the Radar without estimating the angular location of the subjects. Notably, it also superseded the performance of the direct FFT method for the single subject after 40 cm distance measurements. The proposed simpler architecture of single-channel CW radar leveraged with MODWT has several potential applications, including post-disaster search and rescue scenarios for finding the trapped, injured people under the debris, emergency evacuation, security, surveillance, and patient vital signs monitoring.
The effect of internet embeddedness on women’s non-farm employment under the power perception perspective: evidence from rural China
Authors: Yu Song , Yang Lulu , Yang Shimei , Li Lianjun 
Published: January 2024

IntroductionFemale empowerment can promote gender equality and realize women’s comprehensive development, while the Internet has opened up an effective channel for female empowerment.MethodsGiven the relative lack of women’s rights in rural China and the rapid Internet development, this paper, based on the 2021 China Comprehensive Social Survey data, first analyses the effect of Internet embeddedness on rural women’s non-farm employment using the Probit model. Then, it uses the mediation effect model to explore the role of women’s rights perception in the mechanism between Internet embeddedness and women’s non-farm employment. Finally, based on age and regional differences, we also analyze the impact of Internet embeddedness on female non-farm employment.ResultsThe paper draws the following conclusions: (1) Internet embedding can promote female non-farm employment, and the probability of female non-farm employment is 3.71% for each degree of Internet embedding. (2) Internet embedding can enhance women’s perception of their rights and thus promote women’s non-farm employment. (3) Internet embedding can enhance the perception of rights of young rural women, which can promote their nonfarm employment. However, the influence of internet embedding on middle-aged women’s perception of rights is not significant. (4) Internet embedding in the eastern region can enhance women’s perception of rights and realize women’s non-farm employment; on the contrary, in the central and western regions, Internet embedding cannot enhance rural women’s perception of rights.DiscussionTherefore, this paper proposes to release further the impact of the Internet in promoting rural women’s non-farm employment to improve the deprivation of rural women’s rights and promote gender equality and women’s comprehensive development.
Effects of physical activity participation on cognitive impairment in older adults population with disabilities
Authors: Lim Seung-Taek , Kwak Hyo-Bum , Kang Ju-Hee , Chang Eunwook , Joa Kyung-Lim , Park Hee-Jung , Park Dong-Ho 
Published: January 2024

BackgroundExisting research on the association between cognitive function and physical activity in the older adults population with disabilities is limited. Additionally, there is a need to explore avenues for enhancing the longevity and quality of life among these individuals.ObjectiveThis study aimed to investigate the independent and joint associations between cognitive function and levels of physical activity in the older adults population with disabilities.MethodsA total of 315 older adults adults (men = 182, women = 133), identified with disabilities based on medical evaluation, were recruited from the first survey of the Korean Longitudinal Study of Aging (KLoSA). Participants underwent assessments for cognitive function, physical activity (PA), activities of daily living (ADLs), instrumental activities of daily living (IADLs), and grip strength.ResultsADLs (p &lt; 0.001) and IADLs (p &lt; 0.001) scores were significantly higher in the male normal cognitive group compared to both the male and female cognitive impairment groups. In an unadjusted model, disabled older adults individuals who did not meet the recommended PA guidelines showed an increased odds ratio for cognitive dysfunction (OR = 2.29, 95% CI = 1.32–3.97). Those participating in PA at least 1 day per week also demonstrated an elevated odds ratio (OR = 1.22, 95% CI = 1.08–1.38) for cognitive dysfunction compared to those who engaged in regular PA. A negative correlation was observed between K-MMSE scores and grip strength (r = 0.448, p &lt; 0.001).ConclusionThis study provides robust evidence that disabled older adults individuals who do not meet the recommended guidelines for PA or who do not participate in PA at least once a week have an increased likelihood of cognitive impairment compared to those who are regularly active.
Perceptions, facilitators and barriers to the implementation of interpersonal group therapy to treat depression among people living with HIV in Senegal: a qualitative study
Authors: Bernard Charlotte , Mané Idrissa , Ziadeh Salaheddine , Tine Judicaël Malick , Diaw Abibatou , Benzekri Noëlle , Ndiaye Ibrahima , Samba Oumar , Font Hélène , Bottai Thierry , Jacquesy Laurent , Verdeli Helen , Ngom Ndeye Fatou , Dabis François , Seydi Moussa , de Rekeneire Nathalie 
Published: January 2024

BackgroundDepression is highly prevalent in people living with HIV (PLWH) but remains under treated in Sub-Saharan Africa. In this context, we conducted the first study of Group Interpersonal Therapy (IPT) to treat depression in PLWH in Senegal. We assessed the perceptions and experiences of patients and group facilitators, as well as barriers to implementation.MethodsThis study was conducted at the Fann National University Hospital Center in Dakar, the urban capital of Senegal. Qualitative data were collected during the implementation phase (February to June 2020 and then from January to February 2021), with a 6-month pause due to the COVID-19 pandemic. Twenty-five patients and three group facilitators were individually interviewed by a socio-anthropologist. Qualitative data were analyzed thematically.ResultsGroup IPT was perceived as successful and beneficial by patients and facilitators. Patients reported positive experiences with group IPT and sustained outcomes. Beyond improving depressive symptoms, patients reported improvements in their social and professional lives, and the development of skills to prevent relapse. Group facilitators noted the benefits of therapy for their patients and for their professional skills, reporting greater clinical competence and improved supportive skills. Challenges to intervention implementation included confidentiality and patient privacy concerns, healthcare accessibility issues, and time demands.ConclusionIn this first qualitative study of group IPT for depression in PLWH in Senegal, participants described both positive experiences with the intervention and challenges to its implementation. Future studies, conducted in suburban and rural communities outside of Dakar, would further inform the implementation of IPT in Senegal.
SAW velocity reduction and spurious modes suppression on the layer structure
Authors: Hu Richeng , Wu Zhaohui , Li Xinzhi , Shi Bin , Bao Jingfu , Hashimoto Ken-Ya 
Published: January 2024

Abstract
This paper discusses the use of the layered structure for the SAW velocity reduction. First, it is shown that the insertion of SiO2 is crucial between the piezoelectric layer and the base substrate to keep a large electromechanical coupling factor even when the SAW velocity is reduced. It is also shown that the use of a high-velocity substrate such as Si is also crucial for bringing spurious resonances much higher than the main resonance. The impact of Si orientation is also discussed. Next, suppression of transverse mode resonances and lateral leakage is studied. It is shown that the double busbar structure offers Q enhancement through good lateral energy confinement, and its combination with the piston design also gives good transverse mode suppression. Furthermore, discussions are extended to a strong spurious resonance that appears near the anti-resonance.
Regulasi Hukum Lingkungan dan Jaminan Reklamasi dalam Industri Pertambangan di Indonesia
Authors: Irena Florencia , Rahayu Mella Ismelina Farma 
Published: January 2024

Regulasi di Indonesia, Pasal 33 ayat 3 UUD 1945 yang mengatur tentang tanggung jawab untuk menjaga keberlanjutan dan keadilan bagi rakyat, UU No. 3 Tahun 2020 yang mengatur tentang penguasaan negara terhadap sumber daya mineral dan batubara, Keputusan Menteri ESDM No. 1827/K/30/MEM/2018 yang mengatur tentang reklamasi, Hukum Lingkungan, termasuk UU PPLH, menjadi landasan prinsip dalam mengelola lingkungan hidup dan industri pertambangan di Indonesia. Industri pertambangan, sebagai penyumbang devisa terbesar, memberikan dampak positif terhadap perekonomian negara. Namun, aktivitas ini juga menimbulkan dampak negatif terhadap lingkungan, termasuk pencemaran air, udara, dan konflik sosial. Dibutuhkan suatu upaya pemulihan dan, pengembalian lahan bekas tambang ke kondisi semula, yaitu reklamasi, agar dapat mendukung fungsi lingkungan hidup, serta memulihkan dan merestorasi ekosistem yang terganggu, melalui penataan ulang lahan, penanaman vegetasi, dan rekayasa tanah. Penelitian ini bertujuan untuk mengetahui regulasi hukum lingkungan di Indonesia terkait jaminan reklamasi dalam industri pertambangan. Melalui metode normatif dengan pendekatan peraturan perundang-undangan, penelitian dilakukan untuk mengetahui regulasi hukum lingkungan di Indonesia terkait jaminan reklamasi, mulai dari perencanaan pertambangan, evaluasi, penentuan besaran jaminan, penyerahan jaminan, hingga pemulihan jaminan reklamasi dan penentuan besaran pencairan jaminan. Secara rinci akan dibahas mengenai bagaimana regulasi hukum lingkungan terhadap jaminan reklamasi dan prosedur pemberian jaminan reklamasi dalam industri pertambangan di Indonesia, baik dalam tahap eksplorasi, maupun dalam tahap operasi produksi.
The Influence Of Compensation And Work Discipline On Employee Performance
Authors: Sari Septia Ega , Tukirin Tukirin 
Published: January 2024

Performance includes the work results obtained by an employee when completing tasks in accordance with the responsibilities given to achieve company goals. Factors that influence a person's performance will of course be influenced by employee compensation and discipline because income is in the form of money or goods, either directly or indirectly. indirect, which is received by employees as compensation for their services to the company. Meanwhile, the level of employee discipline also has an impact on the individual's performance.
This research aims to understand the impact of compensation and work discipline on the performance of PT employees. Betawimas Brilliant. The research method uses a survey method where the population in this study is PT Betawimas Cemerlang employees, totaling 40 people. Data processing and analysis techniques use the SPSS program. The results of this research state that compensation does not have a significant effect on employee performance, but work discipline has a significant effect on employee performance, as well as simultaneously stating that the results have a significant effect
High-resolution Imaging of a TESS Control Sample: Verifying a Deficit of Close-in Stellar Companions to Exoplanet Host Stars
Authors: Littlefield Colin , Howell Steve B. , Ciardi David R. , Lester Kathryn V. , Everett Mark E. , Furlan Elise , Matson Rachel A. , Fajardo-Acosta Sergio B. , Gnilka Crystal L. 
Published: January 2024

Abstract
The large number of exoplanets discovered with the Transiting Exoplanet Survey Satellite (TESS) means that any observational biases from TESS could influence the derived stellar multiplicity statistics of exoplanet host stars. To investigate this problem, we obtained speckle interferometry of 207 control stars whose properties in the TESS Input Catalog (TIC) closely match those of an exoplanetary host star in the TESS Object of Interest (TOI) catalog, with the objective of measuring the fraction of these stars that have companions within ∼1.″2. Our main result is the identification of a bias in the creation of the control sample that prevents the selection of binaries with 0.″1 ≲ ρ ≲ 1.″2 and Δmag ≲3. This bias is the result of large astrometric residuals that cause binaries with these parameters to fail the quality checks used to create the TIC, which in turn causes them to have incomplete stellar parameters (and uncertainties) in the TIC. Any stellar multiplicity study that relies exclusively upon TIC stellar parameters to identify its targets will struggle to select unresolved binaries in this parameter space. Left uncorrected, this selection bias disproportionately excludes high-mass-ratio binaries, causing the mass-ratio distribution of the companions to deviate significantly from the uniform distribution expected of FGK-type field binaries. After accounting for this bias, the companion rate of the FGK control stars is consistent with the canonical 46% ± 2% rate from Raghavan et al., and the mass-ratio distribution agrees with that of binary TOI host stars. There is marginal evidence that the control-star companions have smaller projected orbital separations than TOI host stars from previous studies.
Systematics in the Cepheid and TRGB Distance Scales: Metallicity Sensitivity of the Wesenheit Leavitt Law
Authors: Madore Barry F. , Freedman Wendy L. 
Published: January 2024

Abstract
Using an updated and significantly augmented sample of Cepheid and tip of the red giant branch (TRGB) distances to 28 nearby spiral and irregular galaxies, covering a wide range of metallicities, we have searched for evidence of a correlation of the zero-point of the Cepheid period–luminosity relation with H ii region (gas-phase) metallicities. Our analysis, for the 21 galaxies closer than 12.5 Mpc, results in the following conclusions: (1) The zero-points of the Cepheid and TRGB distance scales are in remarkably good agreement, with the mean offset in the zero-points of the most nearby distance-selected sample being close to zero, Δμ

o
(Cepheid—TRGB) = −0.026 ± 0.015 mag (for an I-band TRGB zero-point of M

I
= −4.05 mag); however, for the more distant sample, there is a larger offset between the two distance scales, amounting to −0.073 ± 0.057 mag 〈Δμ

o
〉 (Cepheids—TRGB) = −0.026 ± 0.015 mag, for an I-band TRGB zero-point of M

I
= −4.05 mag. (2) The individual differences, about that mean, have a measured scatter of ±0.068 mag. (3) We find no statistically significant evidence for a metallicity dependence in the Cepheid distance scale using the reddening-free W(V, VI) period–luminosity relation: Δμ

o
(Cepheid − TRGB) = − 0.022( ± 0.015) × ([O/H] − 8.50) − 0.003(±0.007).
An Extensive Hubble Space Telescope Study of the Offset and Host Light Distributions of Type I Superluminous Supernovae
Authors: Hsu Brian , Blanchard Peter K. , Berger Edo , Gomez Sebastian 
Published: January 2024

Abstract
We present an extensive Hubble Space Telescope rest-frame UV imaging study of the locations of Type I superluminous supernovae (SLSNe) within their host galaxies. The sample includes 65 SLSNe with detected host galaxies in the redshift range z ≈ 0.05–2. Using precise astrometric matching with SN images, we determine the distributions of the physical and host-normalized offsets relative to the host centers, as well as the fractional flux distribution relative to the underlying UV light distributions. We find that the host-normalized offsets of SLSNe roughly track an exponential disk profile, but exhibit an overabundance of sources with large offsets of 1.5–4 times their hosts' half-light radii. The SLSNe normalized offsets are systematically larger than those of long gamma-ray bursts (LGRBs), and even Type Ib/c and Type II SNe. Furthermore, we find from a Monte Carlo procedure that about

37

−
8

+
6

%

of SLSNe occur in the dimmest regions of their host galaxies, with a median fractional flux value of 0.16, in stark contrast to LGRBs and Type Ib/c and Type II SNe. We do not detect any significant trends in the locations of SLSNe as a function of redshift, or as a function of explosion and magnetar engine parameters inferred from modeling of their optical light curves. The significant difference in SLSN locations compared to LGRBs (and normal core-collapse SNe) suggests that at least some of their progenitors follow a different evolutionary path. We speculate that SLSNe arise from massive runaway stars from disrupted binary systems, with velocities of ∼102 km s−1.