bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic Calcaneoplasty in Haglund's Disease: Surgical Technique, Clinical and Subjective Outcomes
Authors: Cardone Guillermo , Bilbao Facundo , Verbner Jonathan M. , Cafruni Virginia Maria , Carrasco Nelly Marina 
Published: December 2023

Category: Arthroscopy; Ankle Introduction/Purpose: During the last decade, arthroscopic procedures have been replacing open techniques in Haglund's disease treatment due to their considerable advantages. Endoscopic calcaneoplasty is a technique that allows resection of posterosuperior calcaneal exostosis and retrocalcaneal bursitis. The objective of this article is to describe this technique and report its clinical and subjective outcome. Methods: A retrospective cohort study was carried out in patients who underwent endoscopic surgery between July 2014 and March 2020. The patients were clinically and radiologically evaluated. All cases included were studied prior to the intervention and postoperative. All patients who did not show any clinical improvement after 6 months of conservative treatment were surgically treated with endoscopic treatment in the prone position through two posterior arthroscopic portals. Results: In this study, 14 endoscopic calcaneoplasties were performed in 14 patients, with an average follow-up of 40 months. The visual analog scale improved from a preoperative average value of 9.07 to 1.79 after surgery (p> 0.0001). The AOFAS scale rose from 38.71 before surgery to 94.57 postoperative (p> 0.0001). Good subjective results were observed in twelve patients ( 85.71%) and all of them would have surgery again. There were no wound complications or infections. No patient required reoperation. Conclusion: Endoscopic treatment is a useful technique, with good clinical and subjective results and few complications, being a good alternative to open techniques.
Foot and Ankle Surgery Postoperative Complications with Regional vs General Anesthesia
Authors: Vacchiano Margaret E. , Haupt Edward T. , Aziz Keith 
Published: December 2023

Category: Trauma; Other Introduction/Purpose: Regional anesthesia has been increasingly used within orthopaedic surgery. It has been found to decrease opioid use and consumption and has been associated with decreased blood loss and clot formation in some lower extremity surgeries – specifically hip and knee arthroplasty surgery. General anesthesia is not without risks including malignant hyperthermia, laryngeal edema, vocal cord trauma, and delirium. This has led to increased utilization of regional anesthesia in foot and ankle surgery. However, there is a paucity of research that compares the postoperative outcomes in patients treated with regional compared to general anesthesia in these surgeries. We hypothesize the use of regional anesthesia in foot and ankle surgery leads to fewer short-term postoperative complications compared to general anesthesia. Methods: The American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) database was queried from 2006-2018 to identify patients undergoing foot and ankle surgery. Current Procedural Terminology (CPT) codes for all foot and ankle surgery were utilized to determine which participants to include in the analysis. The cohort was divided into patients who received regional anesthesia versus those who received general anesthesia, and comparisons were made on demographic characteristics, and comorbidities, using chi-squared and t-test analyses. Multivariate logistic regressions were performed to identify whether lack of regional anesthesia was an independent risk factor for infection, minor postoperative complications, and major postoperative complications. Major postoperative complications included any complication that had a long-term effect on someone’s life or led to reoperation, while minor postoperative complications included any event that needed medical intervention but did not impact a person’s health long-term. Results: Using the ACS-NSQIP database and CPT codes, there were 12,764 participants for regional anesthesia and 73,481 participants who had general anesthesia. Utilizing logistic regression, this study found that the absence of regional anesthesia was independently associated with an increased risk for minor complications in foot and ankle surgery (Odds Ratio (OR) 1.34, 95% Confidence Interval (CI) [1.25-1.44], p=0.00). The absence of regional anesthesia was not associated with increased risk of major complications in foot and ankle surgery (OR 1.04, CI [0.96-1.12], p=0.32). Patients who received regional anesthesia were older and had more comorbidities than those without regional anesthesia used which may be a reason for the findings for major complications. Conclusion: Regional anesthesia independently reduced the risk of minor postoperative complications up to 30-days following foot and ankle surgery in this study. Patients undergoing foot and ankle surgery may benefit from augmenting their anesthetic plan with regional anesthesia.
Evaluation of the sedative effect of sublingual lorazepam versus placebo in patients underwent endoscopy: a double-blind, randomized controlled clinical trial
Authors: Hasanzarrini Maryam , Nirumandi Jahromi Samira , Mohammad Salehi Amir , Ataei Sara , Seyfi Zohreh , Poorolajal Jalal 
Published: December 2023

Background: Digestive endoscopy (DE) is uncomfortable for most patients. Lorazepam is a potent benzodiazepine with anxiolytic and sedative effects. Objective: This study aims to determine the sedative effect of sublingual lorazepam versus placebo as a premedication in patients who underwent DE. Design: This is a mono-center, double-blind, and randomized controlled trial. Methods: A lorazepam sublingual tablet was made by researchers and physical tests were done on it, then the double-blind placebo-controlled trial was done to investigate the efficacy of 2 mg sublingually administered lorazepam as a premedication for endoscopy. Lorazepam or a placebo tablet was administered sublingually 30 min before the endoscopy. The patients, nurses, and physicians were blinded to the patient group. The depth of sedation was evaluated according to the American Society of Anesthesiology. Results: In all, 116 patients were randomly assigned to take either lorazepam ( n = 58) or a placebo ( n = 58). The results of physical properties tests were acceptable according to United States Pharmacopeia. There were no statistical differences between groups regarding age and gender. In the lorazepam group, 75.8% of patients showed mild sedation, and 24.2% of patients showed no sedation. All of the patients in the placebo had no sedation ( p = 0.001). Time of procedure ( p < 0.001), intraoperative O2 saturation ( p < 0.001), intraoperative heart rate ( p < 0.001), and intraoperative blood pressure ( p < 0.001) were significantly lower in the lorazepam group. No significant or dangerous side effects were observed except a bit of giddiness and dizziness. Conclusion: The results of this study showed that prescription of sublingual lorazepam 25–30 min before endoscopy provided mild sedation. Registration: IRCT201611039014N130 (05/11/2016); https://en.irct.ir/trial/9568 .
Tetraparesis following thoracic spine surgery in a patient with Klippel–Feil syndrome and ABCB4 mutation: a case report
Authors: Da Broi Michele , Nouri Aria , Patet Gildas , Paun Luca , Bartoli Andrea , Molliqaj Granit , Schaller Karl , Tessitore Enrico 
Published: December 2023

Abstract
Background
Klippel–Feil syndrome is a rare condition described in 1912 by Maurice Klippel and André Feil. It is defined as a congenital cervical fusion of at least two vertebrae, associated with a classical triad of clinical signs: short neck, low posterior hairline, and limited range of movement. However, Klippel–Feil syndrome manifests with a vast spectrum of phenotypes, ranging from no symptoms to complete triad, with or without other associated malformations. Most commonly, CCF results from sporadic mutations, even though autosomal recessive, autosomal dominant, or even X-linked inheritance can be detected. The ATP-binding cassette subfamily B member 4 is only expressed in the liver and is involved in biliary phospholipid secretion. The clinical spectrum includes various hepatobiliary pathologies, including low phospholipid-associated cholelithiasis, and has never been associated with musculoskeletal anomalies.

Case presentation
A 55-year-old male Caucasian patient presenting with low phospholipid-associated cholelithiasis syndrome with ATP-binding cassette subfamily B member 4 mutation and liver cirrhosis was referred to our clinic for a liver transplant. A period of 6 months before, the patient underwent a T7–T9 posterior fixation for a T8 osteoporotic fracture. Postoperatively, he was tetraparetic, whereas he was neurologically intact before the operation. At admission to our hospital, he was still tetraparetic and presented with clinical signs of cervical myelopathy. Moreover, he suffered a limitation of cervical range of motion in all directions, short neck, and low posterior hairline. Imaging showed multiple cervical and thoracic vertebral bodies fusion, as well as cervical spine stenosis. Based on the available data, we diagnosed a type 3 Klippel–Feil syndrome according to Samartzis’ classification.

Conclusions
The heterogeneity of KFS and the various potential hereditary links that are known indicate that it is important to highlight all potential cases related to known genetic defects. At present, no association between ATP-binding cassette subfamily B member 4 mutation and congenital cervical fusions has been reported. The other important clinical focus of this case is the appearance of spontaneous tetraparesis after thoracic spine surgery. This mechanism remains unclear, but considering different spinal anatomy it might have been due to difficult intubation and patient’s positioning during his previous operation.
Low-Quality Carbohydrate Intake Is Associated With a Higher Prevalence of Metabolic Syndrome: The AWHS Study
Authors: Muñoz-Cabrejas Ainara , Laclaustra Martin , Guallar-Castillón Pilar , Casasnovas José Antonio , Marco-Benedí Victoria , Calvo-Galiano Naiara , Moreno-Franco Belén 
Published: December 2023

Abstract

Context
The relationship between carbohydrate quality intake and metabolic syndrome (MetS) is of growing interest.

Objective
We aimed to assess the association between the adherence to a dietary carbohydrate quality index (CQI) with the occurrence of MetS in a Spanish cohort of working adults.

Methods
A cross-sectional study was conducted of 2316 middle-aged men, aged 50.9 (SD 3.9) years, with no previous cardiovascular disease, and pertaining to the Aragon Workers’ Health Study (AWHS) cohort. Diet was collected with a 136-item semiquantitative food-frequency questionnaire. The CQI (range 4-15) was based on: dietary fiber intake, a low glycemic index, the ratio of whole grains/total grains, and the ratio of solid carbohydrates/total carbohydrates. The higher the CQI, the healthier the diet. MetS was defined by using the harmonized National Cholesterol Education Programme–Adult Treatment Panel III (NCEP-ATP III) definition. The associations across 3-point categories of the CQI and the presence of MetS were examined using logistic regression.

Results
An inverse and significant association between the CQI and MetS was found. Fully adjusted odds ratios (ORs) for MetS risk among participants in the 10- to 12-point category (second highest CQI category) was 0.64 (95% CI, 0.45-0.94), and in the 13- to 15-point category (highest category) was 0.52 (95% CI, 0.30-0.88), when compared with the 4- to 6-point category (lowest category). Participants with 10 to 12 and 13 to 15 points on the CQI showed a lower risk of hypertriglyceridemia: OR 0.61 (95% CI, 0.46-0.81), and 0.48 (95% CI, 0.32-0.71) respectively.

Conclusion
Among middle-aged men, a higher adherence to a high-quality carbohydrate diet is associated with a lower prevalence of MetS. Triglyceridemia is the MetS component that contributed the most to this reduced risk.
Longitudinal Changes in Quality of Life Before and After Thyroidectomy in Patients With Differentiated Thyroid Cancer
Authors: Kim Byung Hun , Ryu Soo Rack , Lee Jin Won , Song Chang Myeon , Ji Yong Bae , Cho Seok Hyun , Lee Seung Hwan , Tae Kyung 
Published: December 2023

Abstract

Objective
The objective of this prospective study was to assess longitudinal variations in health-related quality of life (HR-QOL) in patients diagnosed with differentiated thyroid cancer (DTC) before and after thyroidectomy.

Methods
A cohort of 185 DTC patients who underwent thyroidectomy between January 2013 and December 2017 and who completed all necessary questionnaires was evaluated. Their HR-QOL was gauged using the University of Washington Quality of Life questionnaire (UW-QOL) and the City of Hope Quality of Life-Thyroid Version questionnaire (QOL-TV) both prior to surgery and at 3 months, 6 months, 1 year, 2 years, 3 years, and 5 years postoperatively.

Results
Out of 185 patients, 150 (81.1%) were female, with an average age of 48.7 ± 12.9 years. For both UW-QOL and QOL-TV, the total composite QOL scores notably declined from preoperative levels to 3 months postoperatively, then gradually improved over 5 years, ultimately exceeding preoperative scores. Factors such as total thyroidectomy, radioactive iodine (RAI) ablation, and postoperative hypoparathyroidism were associated with lower physical composite QOL scores. Patients who underwent remote-access thyroidectomy expressed significantly higher satisfaction with appearance compared with those who had conventional thyroidectomy. Mood and anxiety were major clinical concerns both before and after surgery, showing considerable improvement postoperatively.

Conclusion
For DTC patients, HR-QOL experienced a significant drop 3 months postsurgery, subsequently showing gradual improvement, surpassing preoperative QOL by 5 years. Factors contributing to improved physical QOL included the utilization of remote-access thyroidectomy, less extensive thyroidectomy, and the absence of RAI ablation and hypoparathyroidism.
Increased IGFBP Proteolysis, IGF-I Bioavailability, and Pappalysin Levels in Children With Prader-Willi Syndrome
Authors: Barrios Vicente , Martín-Rivada Álvaro , Martos-Moreno Gabriel Á , Canelles Sandra , Moreno-Macián Francisca , De Mingo-Alemany Carmen , Delvecchio Maurizio , Pajno Roberta , Fintini Danilo , Chowen Julie A , Argente Jesús 
Published: December 2023

Abstract

Context
Prader-Willi syndrome (PWS) is associated with impaired growth hormone (GH) secretion and decreased insulin-like growth factor (IGF)-I levels. Pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC-1, STC-2) regulate IGF binding-protein (IGFBP) cleavage and IGF bioavailability, but their implication in PWS is unknown.

Objective
We determined serum levels of PAPP-As and STCs in association with IGF axis components in prepubertal and pubertal patients with PWS, also analyzing the effect of GH treatment.

Methods
Forty children and adolescents with PWS and 120 sex- and age-matched controls were included. The effect of GH was evaluated at 6 months of treatment in 11 children.

Results
Children with PWS had lower levels of total IGF-I, total and intact IGFBP-3, acid-labile subunit, intact IGFBP-4, and STC-1, and they had higher concentrations of free IGF-I, IGFBP-5, and PAPP-A. Patients with PWS after pubertal onset had decreased total IGF-I, total and intact IGFBP-3, and intact IGFBP-4 levels, and had increased total IGFBP-4, and STCs concentrations. GH treatment increased total IGF-I, total and intact IGFBP-3, and intact IGFBP-4, with no changes in PAPP-As, STCs, and free IGF-I levels. Standardized height correlated directly with intact IGFBP-3 and inversely with PAPP-As and the free/total IGF-I ratio.

Conclusion
The increase in PAPP-A could be involved in increased IGFBP proteolysis, promoting IGF-I bioavailability in children with PWS. Further studies are needed to establish the relationship between growth, GH resistance, and changes in the IGF axis during development and after GH treatment in these patients.
THE GASTRONOMIC IMAGE OF THE TERRITORY: STRUCTURE AND SPECIFICITY
Authors: Belyaeva Maria A. 
Published: December 2023

The article is devoted to the gastronomic culture and its derivative – the gastronomic image of the territory. Gastronomy, as a field of knowledge, reveals the connection between food and culture and is an urgent topic of cultural research. Within the framework of this article, the subject of research is the study of the gastronomic image of the territory from a theoretical point of view.
The author seeks to answer the questions: what are the system-forming elements of the gastronomic culture, how do the concepts of “gastronomic image” / “gastronomic brand” relate, what is the structure and what is the specificity of the gastronomic image of the territory in comparison with other perspectives of the positioning of the territory.
Method and methodology: the ideas of this article are based on systematic, practical, semiotic approaches in understanding the gastronomic culture, modern gastronomic practices, and the gastronomic image of the city.
The novelty and the author’s contribution lies in the theoretical positions that fit into the mainstream of cultural knowledge. The author offers his vision of the system-forming elements of gastronomic culture and his vision of the structure of the gastronomic image of the city as a 4-component fashion: food, places, people, events. The author identifies three specific characteristics of the gastronomic image of the city: 1) authenticity as an optional, not a mandatory feature; 2) dynamism as an indicator of the potentially high variability of the gastronomic image following changing living conditions and available resources; 3) a possible break with the local cultural tradition existing in hidden everyday life, while the gastronomic image is formed in the public sphere with the help of traditional and new media, greedy for hype.
The results of the study can be applied in such an area of applied cultural studies as geobrending. A good theory is a guide to action, if you undertake to form a gastronomic image of the city, you need to understand its structure and specifics.
The scope of the results: geobranding, cultural industries related to food, brand communications in regional media and new media, tourism.
CULTURAL MEANINGS OF FORWARD AND REVERSE PERSPECTIVES IN FINE ART
Authors: Lytov Maxim S. 
Published: December 2023

The relevancy of addressing the problem of forward and reverse perspective in the depiction of space on the plane when teaching drawing to children and students is due to the dominance of geometric stereotypes in their pictures, reflecting the photographic character of the surrounding video environment.
The aim of the study: in the conditions of increasing trends of standardization and unification of the global society – to substantiate the cultural meanings of including the forward and reverse perspectives in the content of teaching drawing – to master the cultural heritage of Old Russian art, to study and preserve the diversity of visual techniques of small ethnic groups of the country, to develop the creative potential of self-expression in drawing “as I see it”.
The methods of analysis, generalization, comparison, contrast, as well as cultural, ecological and complex approaches were used.
The result of the study was the revealed contradiction between the fact of dominance of reverse perspective in the perception of children of different nationalities and representatives of indigenous peoples who have not been exposed to civilization, on the one hand, and the teaching in modern schools of direct linear perspective in drawing as the only “correct”, the formation of stereotypes of geometric representation of the surrounding world in students.
The conclusion is made about the importance of nature- and culture-oriented orientation of teaching drawing to give it individuality, interest in the cultural heritage of the country and the desire to develop modern domestic fine arts. Area of application of the results: pedagogical process of teaching drawing at school and university.
Otentikasi Toge Goreng Sebagai Makanan Tradisional Khas Kota Bogor
Authors: Kurnia Insan , Imroatun Imroatun , Farhah Gina , Amanda Dhea , Erlangga Hazna Nabila , Prabandari Dyah 
Published: December 2023

Taoge goreng merupakan makanan tradisional khas Bogor dengan bahan baku utama taoge dan oncom. Perubahan zaman berdampak pada perubahan keminatan maupun modifikasi terhadap makanan khas, sehingga diperlukan data mengenai keotentikan dari taoge goreng sebagai kuliner khas Bogor. Penelitian bertujuan untuk mengidentifikasi otentikasi taoge goreng sebagai makanan tradisional khas Bogor. Penelitian dilaksanakan pada Bulan Desember 2022-Januari 2023 di Kota Bogor. Penelitian dilakukan dengan survei terhadap pedagang taoge goreng yang eksis di Kota Bogor untuk selanjutnya ditentukan 30 informan secara purposive. Data diambil melalui observasi langsung serta wawancara. Informan pedagang taoge goreng didominasi laki-laki, usia 36-50 tahun, berdagang meneruskan usaha orang tua, serta memulai usaha sejak Tahun 2000. Empat komponen utama taoge goreng yaitu mie kuning, tahu, taoge dan kupat. Lima bahan baku bumbu dinilai wajib digunakan sebagai bagian kekhasan taoge goreng yaitu tauco, oncom, garam, bawang putih dan bawang merah, sementara tujuh bahan baku lain dapat digunakan dapat juga tidak. Pedagang taoge goreng masih didominasi pengolahan secara tradisional menggunakan kayu bakar serta penyajian kemasan menggunakan daun patat.
Analisis Kandungan Gizi Mikro Biskuit Crackers Berbahan Dasar Ikan Patin (Pangasius sp.) dan Daun Kelor (Moringa oleifera)
Authors: Kawareng Andi Tenri , Khuzaimah Ummi , Faisal Muhammad , Wirawanti Ika Wirya , Tyas Leny Eka , Rozi Fahrul , Siddiq Muhammad Nuzul Azhim Ash , Majiding Chaidir Masyhuri , Aryatika Karera , Pijaryani Indria , Anshori Jamil 
Published: December 2023

Pengembangan produk crackers berbahan dasar ikan patin dan daun kelor dapat menjadi alternatif pilihan dalam mengatasi rendahnya kandungan gizi khususnya sumber zat gizi mikro pada makanan selingan. Penelitian ini bertujuan untuk menganalisis kandungan dari zat gizi mikro yaitu vitamin A, vitamin B2, vitamin E , seng dan kalsium pada biskuit crackers berbahan dasar patin dan daun kelor. Metode penelitian ini menggunakan desain experimental study. Penelitian dilaksanakan dilaksanakan selama dua bulan dari oktober-november 2022. Hasil penelitian menunjukkan bahwa crackers memiliki kandungan gizi vitamin A sebesar 40,35 µg/100 g, vitamin B2 sebesar 2,39 mg/100 g, vitamin E 11,09 mg/100 g, seng sebesar 2,76 mg/100, dan kalsium 334,2 mg/100 g. Vitamin B2, vitamin E, seng dan kalsium pada crackers dapat memberikan kontribusi >10% dari total kecukupan gizi harian remaja sedangkan kandungan vitamin A berkontribusi 5-6.5% terhadap kecukupan gizi remaja. Kesimpulan penelitian ini menunjukkan bahwa pengembangan biskuit crackers berbahan dasar ikan patin dan daun kelor dapat dijadikan sebagai pilihan alternatif cemilan yang kaya akan zat gizi mikro bagi remaja.