bluuebunny/crossref_metadata_2025_split huggingface dataset:
MANEJO EN EDAD DE REPRODUCTORAS Y TEMPERATURA DE INCUBACIÓN SOBRE VENTANA DE NACIMIENTO Y CALIDAD DEL POLLITO BB
Authors: Intriago Muñoz Vicente Alejandro , Cedeño Rivera Oscar Adolfo , Hurtado Ernesto Antonio , Rivera Fernández Rubén Darío 
Published: October 2023

Se evaluó el efecto del manejo en edad de reproductoras y temperatura de incubación sobre la ventana de nacimiento y la calidad del pollito bajo un diseño completamente al azar (DCA), conformado por cuatro tratamientos: huevos de reproductoras Cobb 500 de 30 semanas incubados a 37,2ºC (T1), de 34 semanas a 37,5ºC (T2) de 38 semanas a 38ºC (T3) y huevos de 42 semanas a 37,8ºC (T4). Las variables evaluadas fueron: ventana de nacimiento (VDN), ganancia de peso (GDP), absorción del saco vitelino (ASV), peso de órganos (PDO), paquete visceral (PV) y calidad microbiológica (CM) de pollitos Los resultados en VDN evidencian diferencias significativas (p<0,05) entre los tratamientos con más pollitos nacidos para T3; mientras que, T1 obtuvo ganancia de peso más baja 59,8 (g) frente a 71,6 (g) T2 y T4 y 72,9 (g) T3; además, los tratamientos influyeron (p<0,05) en ASV, PDO (a excepción del corazón) y PV. Con respecto al análisis microbiológico, se encontró presencia de E coli para T1 en todas las muestras; los análisis de los tratamientos resultaron negativos para salmonella, aspergilium y penicillium. Se concluye que, los pollitos provenientes de reproductoras de menor edad incubados a temperatura más baja tardan más en nacer, con detrimento en las variables estudiadas inclusive la calidad del pollito BB.
Characteristics of new cases of infiltrative pulmonary tuberculosis in patients having HIV infection with multidrug resistance of the pathogen according to multi-layer spiral computed tomography
Authors: Bazhenova Yu. V. , Zorkaltseva E. Yu. , Plotnikova Yu. K. , Vorobeva O. A. 
Published: October 2023

Background. Identification of the characteristics of the pulmonary tuberculosis process using multi-layer spiral computed tomography (MSCT) in patients with tuberculosis and HIV infection is important in the diagnosis of tuberculosis, determining the dissemination of the process and its dynamics during treatment. The aim. To determine the initial characteristics and dynamics of infiltrative tuberculosis according to MSCT in patients with and without HIV infection, with and without multidrug resistance (MDR) of Mycobacterium tuberculosis who were treated in a hospital. Materials and methods. 126 patients aged 19–59 years with tuberculosis, combined with HIV infection and without HIV infection were examined. For statistical processing, we used MS Excel (Microsoft Corp., USA) software package. Results. Patients with tuberculosis and HIV infection in comparison with patients with tuberculosis and without HIV had more expressed intoxication syndrome and respiratory impairement in the clinical picture (p < 0.00001). Patients with coinfection were more likely to suffer from alcohol (p < 0.05) and drug addiction (p < 0.001). According to MSCT, the pathological process in HIV-positive patients with pulmonary tuberculosis was more disseminated (p < 0.05), included severe intrathoracic lymphadenopathy (p < 0.0001), more common pleural lesions (p < 0.005), less common destructive changes (cavities) (p < 0.001) and outcomes in form of fibro-cavernous tuberculosis (p < 0.01). Process regression was slower in patients with tuberculosis and HIV (p < 0.005). According to MSCT, extensive lung damage, intrathoracic lymphadenopathy were more often found in patients with MDR in coinfection (p < 0.05). Cavities and fibro-cavernous tuberculosis outcomes were more common in patients with tuberculosis without HIV infection and with MDR (p < 0.05). Conclusion. MSCT provides detailed information about the pathological process in the lungs and its dynamics under the treatment of tuberculosis and HIV infection.
Study of anti-inflammatory and antinociceptive properties of new derivatives of condensed 3-aminothieno[2,3-b]pyridines and 1,4-dihydropyridines
Authors: Bibik I. V. , Bibik E. Yu. , Pankov A. A. , Frolov K. A. , Dotsenko V. V. , Krivokolysko S. G. 
Published: October 2023

Background. α-сyanothioacetamide derivatives are promising targets for the search for effective and safe antinociceptive agents with antipyretic and antiexudative activity. The aim. To conduct in vivo experimental study of anti-inflammatory and analgesic effects of new thienopyridines and 1,4-dihydropyridines derivatives. Materials and methods. The synthesized cyanothioacetamide derivatives were subjected to virtual bioscreening using Swiss Target Prediction online service. 140 laboratory rats were randomly distributed into intact and control (dextran edema) groups, reference groups (acetylsalicylic acid and nimesulide) and ten experimental groups for the investigated derivatives of thieno[2,3-b]pyridine and 1,4-dihydropyridine. The anti-inflammatory activity of the compounds at a dose of 5 mg/kg was evaluated by modeling acute dextran edema of rat paw. Determination of analgesic activity was carried out in the hotplate analgesic assay on 130 rats in comparison with sodium metamizole. Results. 1,4-dihydropyridines AZ331 and AZ420, as well as thienopyridine derivative AZ023 were determined to have strong anti-inflammatory activity (2.5 times more effective than nimesulide and 2.2 times more effective than acetylsalicylic acid). Compounds AZ023, AZ331 and AZ383 showed pronounced analgesic activity. The time of stay on the heated plate for rats of experimental groups that were fed with AZ331 and AZ383 for prophylactic purpose was respectively 9.56 and 9.93 times more than the same index in the reference group. The animals receiving AZ023 were characterized by an increase in the latent reaction time up to 241.2 seconds, which is 14.53 times higher than that in the rats received sodium metamizole. Conclusion. New thienopyridine and 1,4-dihydropyridine derivatives with high antiinflammatory and analgesic activity were synthesized and studied; they were recognized as promising targets for further preclinical studies.
Pseudomembranous colitis complicated by toxic megacolon in oncological patients
Authors: Morikov D. D. , Kartashova V. V. , Shelekhov A. V. , Nikolaeva N. A. 
Published: October 2023

In recent years, information on the increase in the incidence of infection associated with Clostridioides difficile (CDI) has appeared in the literature. It is known that C. difficile which causes pseudomembranous colitis (PMC) most often affects debilitated patients who receive treatment for the main pathology for a long time. That is why PMC is most common in cancer patients receiving long-term and aggressive anticancer treatment, which is often accompanied by the use of several courses of antibiotics. The result of the irrational use of antibiotics, incorrect PMC therapy may be the formation of toxic megacolon, intestinal perforation, sepsis, which in turn is fraught with a fatal outcome. It is this state of affairs that aroused our interest in the study of this topic. The steady increase in the incidence of Clostridioides difficile infection makes it particularly relevant to study CDI problem in relation to cancer patients, since they most often have a wide range of risk factors for developing clostridial infection. The article presents an overview of domestic and foreign sources describing this pathology, discusses epidemiology, pathogenesis, clinical picture and current understanding of the CDI treatment. At the end of the review, we present a case of successful treatment of pseudomembranous colitis after stoma closure, which was complicated by the development of toxic megacolon. Colproctectomy was performed as part of the complex treatment of this pathology. The patient received respiratory, renal replacement, hepatoprotective, antibiotic and antifungal therapy and other treatments.
Probiotic consortiums: Structure and antagonistic activity against opportunistic bacteria and human normobiota (using the example of <i>Escherichia coli</i>) <i>in vitro</i>
Authors: Pendyukhova A. S. , Belkova N. L. , Savinova J. S. , Voropaeva N. M. , Smurova N. E. , Klimenko E. S. , Kondratov I. G. , Semenova N. V. , Rychkova L. V. 
Published: October 2023

Background. Using probiotic preparations based on consortia of microorganisms not only helps to restore the balance of the intestinal microbiota, but also increases the therapeutic effect of probiotics. Promising sources for obtaining probiotic consortia are milk products that have undergone natural fermentation with the help of spontaneously formed microbial consortia. The aim. To study the structure of five microbial consortia with probiotic properties from naturally fermented milk products and to assess in vitro their antagonistic activity against opportunistic bacteria and a representative of the human normobiota – Escherichia coli. Materials and methods. The structure of bacterial consortia was analyzed by sequencing methods. The antagonistic activity of the consortia was assessed by the disk diffusion method. Results. It has been established that the studied microbial consortiums are represented by Enterococcus spp. and Streptococcus spp. bacteria. In consortiums No. 1, No. 2, and No. 3, Enterococcus bacteria dominated, while in consortiums No. 4 and No. 5, Streptococcus dominated. Antagonistic activity was shown against four isolates of opportunistic bacteria: Klebsiella pneumoniae No. 493, Enterobacter hormaechei No. 372, Staphylococcus aureus No. 4 and Pseudomonas aeruginosa No. 25 IMB, as well as against one representative of the human normobiota – Escherichia coli No. 495. The highest growth delay zone is found in E. coli No. 495 isolate. Three test cultures (K. pneumoniae No. 509, E. coli ATCC25922 and P. aeruginosa No. 3 IMB) exhibited more dense growth around probiotic consortia. Conclusion. The results of the study showed that the effect of probiotic consortia differing in the composition of microorganisms can be neutral and bactericidal. The presence of antagonistic activity in the studied microbial consortia against multiresistant isolates of opportunistic bacteria is a prospect for creating probiotics with antibacterial properties.
Obesity as a risk factor for chronic kidney disease: a contemporary view on the problem. Review
Authors: Chernyshov V. A. , Nesen A. A. 
Published: October 2023

The review article is devoted to an actual clinical problem of participation of obesity in development and progression of chronic kidney disease (CKD). Some pathogenic links due to which a negative renal effect of obesity is mediated including in particular, dyslipidemia (DLP), endothelial dysfunction (ED) of renal vessels, activation of renin‑angiotensin‑aldosterone system (RAAS), arterial hypertension (AH), a production of adipose tissue mediators with renal injuring properties such as leptin, tumor necrosis factor‑α, interleukines 1,6,8 are discussed. The data about the main factors of progression of renal damage associated with obesity included insulin resistance (IR), hyperinsulinemia, DLP, systemic and renal hemodynamic disorders caused by activation of RAAS (AH, intraglomerular hypertension) are given. The role of metabolic syndrome and its components in pathogenesis of CKD as well as a role of diabetes mellitus (DM) frequently combined with obesity in development of diabetic kidney disease (diabetic nephropathy) is generalized. Among adipokines a special attention in the present review is paid for pathogenic role of leptin and adiponektin in obesity with its conditions promoted renal damage. The participation of resistance to leptin in the pathogenesis of CKD through such links as IR, ED, oxidative stress and inflammation is discussed. The role of ED and glomerular hyperfiltration in pathogenesis of microalbuminuria is elucidated. The significance of injury of kidney tubular cell structures so called podocytes in pathogenesis of CKD in obesity is uncovered. The clinical significance of early revealing of renal pathology as well as body weight, glycemia level, arterial blood pressure control and following of healthy mode of life in reduction of risk development of CKD associated with obesity, DM and other metabolic disorders is generalized. It’s emphasized that evaluation of lipid and carbohydrate exchange parameters, serum leptin level, IR indices is considered to be perspective for diagnostics of renal damage in obesity.
Spiritualitas inkarnatif sebagai fondasi pendidikan kristiani yang inklusif
Authors: Sirait Jannes Eduard 
Published: October 2023

Inclusive education is proclaimed as an innovative solution to expanding access to education for children with special needs or persons with disabilities. Christian education also has the same responsibility to fulfill the needs of persons with disabilities, especially in spirituality, but this has not been consistently actualized. This study aims to explain the narrative of the incarnation of Jesus as spirituality to build inclusive Christian education. The method used is descriptive qualitative. The findings obtained from this research are that there are spiritual values in the narrative of the incarnation of the Lord Jesus, which can become the foundation for implementing inclusive Christian education. This foundation is needed as God's way of embracing the integrity of creation without distinction through His incarnation. AbstrakPendidikan inklusi dicanangkan sebagai solusi inovatif perluasan akses pendidikan bagi anak berkebutuhan khusus atau penyandang disabilitas. Pendidikan Kristiani juga memiliki tanggung jawab yang sama dalam pemenuhan kebutuhan penyandang disabilitas terutama pada aspek spiritualitas, namun saat ini hal tersebut belum teraktualisasikan secara konsisten. Penelitian ini bertujuan untuk memberikan penjelasan tentang narasi inkarnasi Yesus sebagai spiritualitas untuk membangun pendidikan Kristiani yang inklusif. Metode yang dipergunakan adalah kualitatif deskriptif. Temuan yang diperoleh dari penelitian ini adalah terdapat nilai-nilai spiritual dalam narasi inkarnasi Tuhan Yesus yang dapat menjadi fondasi dalam penyelenggaraan pendidikan Kristiani yang bersifat inklusif. Fondasi tersebut dibutuhkan, sebagaimana cara Allah merengkuh keutuhan ciptaan tanpa pembedaan melalui inkarnasi-Nya
Rekonstruksi model pendidikan spritual di era revolusi 4.0 melalui pembacaan Ulangan 6:4-7
Authors: Tanyid Maidiantus , Kataruhan Junjung 
Published: October 2023

This paper discusses the model of spiritual education based on Deuteronomy 6:7 in the era of Revolution 4.0. The situation provides understanding for teachers as parents to recognize the forms of spiritual teaching they can apply at school. The purpose of this research is achieved by using a collaboration of qualitative description methods with hermeneutics. The contribution of the spiritual education model version of Deuteronomy 6:7 provides the role of a teacher to apply spiritual education continuously both at school and at every opportunity, so every Christian is obliged to adorn life with good spirituality, especially in preparing students for the era of revolution 4.0, which is a system that leads to all orders, especially in the current education system. AbstrakTulisan ini membahas tentang model pendidikan rohani berdasarkan Ulangan 6:7 di era revolusi 4.0. Situasi tersebut memberikan pengertian bagi para guru sebagai orang tua untuk mengenal bentuk-bentuk pendidikan rohani yang dapat mereka terapkan di sekolah. Tujuan penelitian ini dicapai dengan menggunakan kolaborasi metode kualitatif deskripsi dengan hermeneutika. Kontribusi model pendidikan rohani versi Ulangan 6:7 memberikan peran seorang guru mengaplikasikan pendidikan rohani secara terus-menerus baik di sekolah maupun di setiap kesempatan, maka setiap orang Kristen wajib menghiasi kehidupan dengan spiritualitas yang baik, terutama dalam menyiapkan peserta didik dalam mempersiapkan diri menghadapi era revolusi 4.0. yang merupakan sebuah sistem yang menuju pada semua tatanan secara khusus pada sistem pendidikan saat ini.
Dari relasi menuju partisipasi: Sebuah teologi keterhisaban identitas manusia ke dalam imago Dei pada konteks autisme
Authors: Masnidar Sherly 
Published: October 2023

This article, focusing on the theology of belongingness, centers its concern on the discriminatory interpretation of the theology of imago Dei towards individuals living with autism. Superficially, our understanding of the theology of imago Dei (image of God) legitimizes human identity as perfect creations due to their resemblance to God. Therefore, individuals living with autism are often considered outside the realm of imago Dei identity due to their limitations in physical, cognitive, and social functions. This article aims to elucidate the complexity of human identity, emphasizing that humans cannot be comprehended solely based on their physical, cognitive, and social functions. To achieve this goal, through a constructive theological approach, this article presents the participative theology of imago Dei as the fourth model of imago Dei theology, following the functional, substantial, and relational models. Ultimately, this article formulates a participative theology of imago Dei that guides us to comprehend humans' belongingness within the Imago Dei fully. Thus, we understand the essence of humanity as unrestricted by any capability reference, providing an equal space for individuals living with autism. AbstrakArtikel yang berfokus pada teologi keterhisaban (theology of belongingness) ini mendasarkan persoalannya pada pemaknaan teologi imago Dei yang diskriminatif terhadap orang yang hidup dengan autisme. Secara dangkal, teologi imago Dei (gambar Allah) kita pahami guna melegitimasi identitas manusia sebagai ciptaan yang sempurna karena kesegambarannya dengan Allah. Itulah sebabnya, orang yang hidup dengan autisme dianggap tidak termasuk ciptaan yang menggambarkan identitas Imago Dei karena keterbatasan fungsi fisik, kognitif, dan sosialnya. Tujuan artikel ini adalah untuk memaparkan tentang kompleksitas identitas manusia sehingga manusia tidak dapat dipahami hanya berdasarkan fungsi dan substansi fisik, kognitif, juga sosialnya. Untuk mencapai tujuan itu, melalui pendekatan teologi konstruktif, artikel ini menawarkan teologi imago Dei partisipatif sebagai model keempat teologi imago Dei, setelah model fungsional, substansial, dan relasional. Pada akhirnya, artikel ini menghasilkan teologi imago Dei model partisipatif yang menuntun kita memahami tentang keterhisaban manusia secara penuh ke dalam Sang Imago Dei. Dengan demikian, kita memahami hakikat manusia secara utuh yang tidak terikat pada acuan kemampuan apapun, sehingga ada ruang perimaan yang sama bagi orang yang hidup dengan autisme.
TAX POLICY AND FEATURES OF ITS IMPLEMENTATION IN WARTIME CONDITIONS
Authors: Holovai Nadiia 
Published: October 2023

The article examines the main problems and determines further ways of adapting the domestic economy to the modern paradigm of socio-economic relations that have developed in the new realities of the martial law. The purpose of the article is to reveal the essence of tax policy and systematize the methods of its implementation in modern economic conditions.
During the research, it was established that the basis of fiscal policy is the tax policy, which ensures the organization of tax planning, regulation and control at the state level. Tax policy serves as the basis for creating a mechanism for economic growth of the state, growth in the level of its gross domestic product and national income.
The thesis is proved that the priority task of the state in terms of tax policy is the creation of a stable and effective tax system at the national level, which would enable the construction of an effective taxation system, namely a fair approach to taxation of all categories of taxpayers, the formation of a sufficient volume of tax payments to the budgets of all levels, as well as creating the necessary factors for Ukraine's further integration into the world community.
Approaches to determining the essence of tax policy are summarized, its role in state regulation of socio-economic relations is substantiated. It has been established that today the tax policy is fully oriented to the existing market situation and, depending on the situation, determines the relationship between taxpayers and the state.
Based on the conducted research, the following conclusions were drawn: firstly, during the period of full-scale Russian military aggression in Ukraine, the domestic economy managed to adapt to functioning in a new paradigm; secondly, the Government settled the main issues and determined the specifics of income tax, value added tax, excise tax and single tax for business entities during the martial law period. At the same time, taking into account the modern challenges caused by military aggression on the part of Russia, the main strategic task of tax policy in Ukraine today is the accumulation of tax revenues for national security and defense and for the implementation of martial law measures in order to stabilize the economic situation in Ukraine .
Iopromide safety assessment in a radiology department: A seven-year retrospective characterization of adverse events
Authors: Joaquim João , Matos Cristiano , Mateos-Campos Ramona 
Published: October 2023

BACKGROUND: Since the mid-20th century, contrast agents have been widely used in radiology due to their ability to provide high-definition radiographic images and greater precision in diagnostic exams. Different types of contrast agents are used in image diagnosis, namely radiological media. Despite being considered safe, there are still uncertainties about their safety profile, interactions, and incidence of adverse drug reactions in real-world settings. OBJECTIVE: To characterise the pattern of adverse events, during 7 years, in a radiology unit. METHODS: We performed a retrospective observational and descriptive study at an Image Center in Portugal between August 2012 and October 2019. A total of 77,449 computed tomography (CT) were registered, and from those 15,640 cases of iopromide were used as a contrast agent. The authors have accessed, under the authorization, the data of adverse events and procedures after the event. RESULTS: Most of the hypersensitivity events were immediate or with a short time of onset, with the majority of cases developing events with skin involvement and mild degree, where the most common events were papules (n = 60), pruritus (n = 42), erythema (n = 27) and urticaria (n = 14). Severe events, including hypersensitivity, were mainly represented by vomiting (n = 11), stridor (n = 8), breathing difficulties (n = 7) and syncope (n = 3). Abdominal-pelvic CT exam presented a higher frequency of adverse events. CONCLUSION: Despite all the current information about iopromide usage, the utilization of this agent is not abstent of risks and its safety profile not fully established. Most frequent symptoms were local, as skin adverse events, including papules, pruritus and erythema. Common medications used to treat or control adverse events were frequently hydrocortisone, clemastine and methylprednisolone.