bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prognostic Implications of CD15 Antigen Expression in patients with acute myeloid leukemia
Authors: Li Zhen , Xu Jiegang , Liu Shixue , Tan Ya , Wang Ping , Wang Li , Xu Shuangnian 
Published: January 2025

Abstract

The prognostic significance of CD15 antigen in acute myeloid leukemia (AML) has been evaluated with conflicting results in various studies. However, existing results are limited and further investigation into additional prognostic parameters is necessary. This study aimed to evaluate the impact of CD15 antigen on survival prognosis in patients with de novo AML (dn-AML). We analyzed CD15 antigen expression on diagnostic samples from 676 patients with dn-AML by flow cytometry. Utilizing a 20% positivity threshold, the cohort was stratified into CD15 positivity (56.07%) and CD15 negativity (43.93%) groups. The CD15 negativity group demonstrated a lower complete remission rate (P = 0.006), a higher relapse rate (P = 0.002) and increased mortality (P<0.001) compared to the CD15 positivity group. According to the log-rank test, the CD15 negativity group exhibited significantly shorter overall survival (OS) (P<0.001) and disease-free survival (DFS) (P<0.001). Multivariate analysis identified CD15-positivity, TP53 mutation, European Leukemia Net (ELN) risk category, bone marrow transplant status, white blood cell (WBC) count and hemoglobin levels as independent prognostic factors associated with OS. A visualized nomogram was developed to predict OS and demonstrating notable performance with a C-index of 0.778. Compared to the ELN risk model, calibration plots and decision curve analyses indicated superior discrimination, calibration and net benefits. The time-dependent receiver operating characteristic (ROC) curves for 1-, 2-, and 3-year survival also performed robustly (AUC = 0.256, 0.154, and 0.126 respectively). Our study provides a comprehensive perspective on the role of CD15 antigen as an independent prognostic marker in dn-AML patients. This prognostic model leverages readily available clinical data to enhance predictive accuracy, identify potential risks and support AML therapeutic decision-making.
Exclusive Human Milk Diet Is Associated with Lower Risk of Motor Function Impairment by Three Years of Age
Authors: Chou Fu-Sheng , Zhang Jing , Villosis Maria Fe , Lakshmanan Ashwini 
Published: January 2025

Abstract

Objectives:
To evaluate the association of an exclusive human milk diet (EHMD) with motor function by three years of corrected age among infants born at less than 32 weeks of gestation.
Methods:
We conducted a retrospective study between 2018 and 2021. Infants who received an EHMD for > 75% of days between first day of diet fortification and 33 6/7 weeks postmenstrual age were assigned to the EHMD group. We used inverse propensity sores to balance potential confounders and developed a mixed-effects logistic regression model to assess the association.
Results:
After adjusting for demographics and morbidities, an EHMD was found to be associated with a reduced risk of motor function impairment, with an odds ratio of 0.74 (95% confidence interval of 0.56–0.98, p-value = 0.033).
Conclusions:
An EHMD is associated with a decrease in early childhood motor function impairment among infants born at less than 32 weeks of gestation.
Qu-Shi-Jie-Du decoction for prevention of recurrence and metastasis in high-risk stage II/III colon cancer: Study protocol for a double-blind, randomized, placebo-controlled trial
Authors: Chen Ya-dong , He Zi-yan , Zhao Wen-jie , He Yi-han , Liu Yi-hong , Zhu Yan-juan , Yu Ya-ya , Xiao Zhen-zhen , Chang Xue-song , Liu Zong-bin , Zhang Hai-bo 
Published: January 2025

Abstract

Background
Colorectal cancer is one of the most common and fatal cancers worldwide. Despite therapeutic advancements, patients with stage II and III colon cancer often experience recurrences and metastases, particularly to the liver, leading to suboptimal disease-free survival rates and decreased long-term survival. Qu-Shi-Jie-Du decoction (QSJDD), a traditional Chinese herbal formula, may prevent cancer recurrence and spread by boosting immunity, reducing inflammation, and inhibiting tumour growth. Preliminary studies have demonstrated that QSJDD reduces liver metastasis in patients with colon cancer. However, robust clinical evidence is required to confirm its efficacy and safety. This study aims to evaluate the safety and efficacy of QSJDD in preventing colon cancer recurrence and liver metastasis, thereby offering a potential adjunctive therapy to improve patient outcomes.
Methods
This multicentre, double-blind, randomised, placebo-controlled trial includes 336 high-risk patients with stage II or III colon cancer from 10 hospitals across China. After surgery and chemotherapy (fluorouracil monotherapy, CAPEOX or mFOLFOX6), 168 patients will be randomised to either the intervention (QSJDD compound granules) or placebo group. The treatment lasts for 6 months, followed by a 3-year follow-up period with assessments conducted every 6 months. The primary endpoint is the 3-year disease-free survival rate, whereas the secondary endpoints include 1- and 2-year relapse rates, overall survival, and variations in the Traditional Chinese Medicine Dampness Syndrome Scale. Safety outcomes including adverse events, will also be monitored. Additionally, the blood and gut microbiomes of patients will be analysed to investigate the effect of QSJDD in delaying the metastasis of colon cancer.
Discussion
This trial will determine the efficacy and safety of QSJDD and provide evidence regarding its role in the adjuvant treatment of colon cancer.
Trial registration
Chictr.org.cn Identifier: ChiCTR2300078971. Registered on 22nd December 2023.
Ontogeny of Inflorescences and Flowers in the Brownea Clade (Fabaceae: Detarioideae): A morphologically diverse lineage of legumes
Authors: Rodrigues Ana Tereza Novaes Parga , Falcão Marcus José Azevedo , Mansano Vidal de Freitas 
Published: January 2025

Abstract

The subfamily Detarioideae stands out among legumes as a clade with remarkable diversity in floral morphology. Within this subfamily, the Brownea clade, characterized by its Neotropical distribution, exhibits significant meristic variability in the perianth, androecium, and gynoecium. These structures vary in size, shape, color, and pubescence. This floral diversity is associated with different pollination syndromes, including entomophily, ornithophily, and chiropterophily. Despite the monophyly of the Brownea clade, the phylogenetic and taxonomic relationships among its seven genera remain inadequately resolved. In such groups, studies on floral ontogeny are crucial to understanding the processes driving variations in floral morphology. These studies also aim to identify potential autapomorphies, synapomorphies, plesiomorphies, and homoplasies that could aid in the systematics of the group. This study aims to expand the understanding of the morphology and development of inflorescences and flowers in six species from five morphologically diverse genera within the Brownea clade. The study provides ontogenetic descriptions of Brownea longipedicellata, Browneopsis macrofoliolata, Heterostemon mimosoides, Macrolobium suaveolens, Paloue paraensis, and Paloue speciosa, comparing these findings with existing studies on Detarioideae. In doing so, it contributes to the broader understanding of floral evolution in the Leguminosae family. In addition to supporting the systematics of the group, the study explores how floral morphological adaptations relate to their respective pollination syndromes. Given the lack of studies addressing the nectariferous nature of flowers in this clade, we also conduct anatomical analyses of the hypanthium in these species to enhance knowledge of their systematics at an anatomical level
Clinical outcomes of Dolutegravir treatment in people living with HIV in Brazil: Protocol for the CODE Cohort
Authors: Brites Carlos , Luz Estela , Stelitano Cristiani , Bahia Fabianna , Lacerda Marcus Vinícius Guimarães , Ramalho Aline , Cardoso Sandra Wagner , Madruga Valdez , Reuter Tânia , Barbosa Alexandre Naime , Speahack Rosa Dea , Bay Monica Baumgardt , Newman Tâmara , Morejon Karen , Patelli Maria , Leal Fábio , Sprinz Eduardo , Murray-Krezan Cristina , Carmody Mary , Anderson Jess , Aragon Alejandro , Chase Benjamin , Zajdenverg Roberto , Jones Bryn , Dutra Fatima , Page Kimberly 
Published: January 2025

Abstract

The Clinical Outcomes of Dolutegravir Treatment in People Living with HIV in Brazil (CODE) cohort study is a multicenter, prospective, observational study designed to evaluate the safety and efficacy of Dolutegravir (DTG)-based antiretroviral therapy (ART) among people living with HIV across diverse settings in Brazil. With the recent global shift towards DTG as a preferred option for first-line ART, particularly in low- and middle-income countries, there is vital need for comprehensive real-world data to inform its widespread use. CODE aims to fill this knowledge gap by assessing the clinical outcomes of both ART-naïve and ART-experienced patients initiating DTG-based regimens, as well as those who have switched from non-DTG-based ART. The primary objective of this study is to determine the proportion of patients who discontinue DTG due to any adverse events, specifically focusing on metabolic and psychiatric outcomes. Secondary objectives include evaluating the rates of virological suppression, the occurrence of immune reconstitution inflammatory syndrome (IRIS), changes in body mass index (BMI), and the development of HIV drug resistance. The CODE cohort will enroll approximately 5000 participants from multiple clinical sites across Brazil, including 2500 ART-naïve individuals, 1000 patients switching to DTG-based regimens for various reasons, and a comparator group of 1500 individuals who initiated non-DTG-based ART between 2013 and 2016, before DTG was available in the country. Participants will be followed for up to 36 months, with data collection points at baseline, 6, 12, 24, and 36 months. This study is expected to generate critical insights into the long-term outcomes associated with DTG-based ART, particularly in real-world settings that reflect the complexities of routine clinical care. By providing robust data on the effectiveness and safety of DTG in a diverse patient population, the CODE study aims to contribute to the optimization of HIV treatment strategies both in Brazil and globally.
A Framework for Intelligent Color Processing and Design Optimization in UI/UX Systems
Authors: Yeboah Donald , Osei-Wusu Franco , Asiedu William , Asante George , Antwi Elvis Sarfo , Muntanka Siddique Abubakr , Ackah Ishmael Ampong , Olowookere Ganiyat 
Published: January 2025

Abstract

The increasing demand for engaging UI/UX designs has highlighted the importance of color selection as a critical element influencing user engagement and aesthetics. However, existing design tools such as Figma and Adobe XD lack advanced, context-aware AI functionalities, particularly in areas like automated palette generation, real-time analytics, and beginner-friendly interfaces. These gaps hinder accessibility for novice designers and force reliance on third-party plugins, which can complicate workflows. This study introduces AI-UIX, an AI-driven system that integrates functionalities such as image-based color extraction, palette generation using additive and subtractive models, and AI-powered recommendations through third-party APIs. The system is developed using modular methodologies and evaluated through computational complexity analysis, expert validation rubrics, and user-centered metrics like ease of use and feature relevance. Results showed that AI-UIX significantly enhances design workflows by automating color selection and generating contextually relevant palettes. Expert validation indicated strong accuracy and usability, with over 90% of participants rating the system as highly effective and user-friendly. Furthermore, computational analysis demonstrated linear scalability, making the system adaptable for both novice and advanced designers. AI-UIX addresses key limitations in existing tools and provides a streamlined, intuitive interface that bridges the gap for users with limited design expertise. This innovation has the potential to transform UI/UX design processes and will be further refined based on broader user feedback to extend its capabilities.
A comparison of an intensive short-term dynamic group therapy to a DBT skills group program for people with personality vulnerabilities (a randomised pilot study for feasibility)
Authors: Walker Sarah , Bowman Candice , Hollyer Penelope , Gibson Alastair , Gutjahr Sigrun , Lamb Kristy , Frederickson Jon 
Published: January 2025

Abstract

Background: Intensive short-term dynamic Psychotherapy (ISTDP) is a structured, short-term psychotherapy that focuses on emotional processing and the resolution of internal conflicts. This randomised pilot and feasibility study evaluated the implementation of a novel 12-week group program based on ISTDP model, and compared clinical outcomes in reducing symptoms associated with personality vulnerabilities (e.g., emotion regulation, self-harm). The setting of the study was an Australian Public Hospital Service.
Methods: The study design was a randomised pilot study for feasibility. Participants were consumers who were referred to a brief intervention service for personality disorders. Participants were randomly assigned to either the ISTDP group or DBT group (treatment as usual). Outcome measures included questionnaires (DASS-21, DERS-18, DES-II, DBTWCCL) assessing mood and distress, emotional dysregulation, disassociation, and DBT skill use. Feasibility outcomes, such as recruitment, attrition, and consumer experiences of the therapy, were also evaluated.
Results: A total of 15 participants were recruited, with nine randomly allocated to the ISTDP group and six to the DBT group. Both groups showed improvements in clinical symptoms, including reductions in depression, emotional dysregulation, and dissociation. The ISTDP group also demonstrated a reduction in anxiety and stress. Follow-up surveys indicated that participants found both group interventions relevant, useful, and beneficial for managing their thoughts and emotions.
Conclusion: Both the ISTDP and DBT interventions were well received by participants, and no adverse events were reported, further supporting their potential for implementation in public hospital settings.
Identification of the nature of the formation of surface defects in the body of the pipe intended for the oil and gas industry
Authors: Mammadov Arif , Namazov Subhan , Babayev Agil , Ismailov Nizami , Huseynov Mukhtar , Quliyev Faiq 
Published: January 2025

This paper presents the results of studies identifying the nature of the formation of defects in the body of a pipe intended for use in the oil and gas industry. A close visual examination of the pipe surface was carried out. Films were detected on the outer surface of the pipes, and multiple irregularities in the form of scales were found on the inner surface. Metallographic analysis of these defects demonstrated layer of scale with elevated surface morphology on the outer surface of the film and dense homogeneous oxides without relief in the internal cavity of the film. X-ray examination of the pipe surface revealed the presence of iron oxides such as FeO, Fe2O3 and Fe3O4 in the films. Combination of metallographic investigations enabled assess to the contamination of steel with non-metallic inclusions such as oxides and silicates. It has been established that non-metallic inclusions also contain Ca, Na and Al and they are predominantly single-phase.
Despite the presence of foreign inclusions, the microstructure of the pipe is represented by a homogeneous ferrite-pearlite mixture, characteristic of the hot-deformed state. Ferrite grains have an equiaxial round shape with an average size of 25–30 microns, and the cementite component of the pearlite grains has a lamellar shape. Metallographic studies of defects were also carried out. Views of the outer surface of a pipe fragment in different sections are presented. It has been established that the thickness of the oxide layer on the surface of the film is uneven and varies in the range of 50–100 microns. In the inner areas of metal under the surface of the film accumulations of small (1–5 μm) rounded oxide inclusions of Mn and Si were detected.
Psychology of patient adaptation to the use of artificial intelligence in screening for chronic noncommunicable diseases
Authors: Seliverstov P. V. 
Published: January 2025

Introduction. Today, the traditional model of medical care is being supplemented and partially replaced by new forms of its implementation. Thus, technologies based on artificial intelligence take over the functions of diagnosis, treatment, screening and monitoring of chronic diseases.Aim. To develop a medical methodology for remote questionnaire screening of chronic kidney disease in young people to optimize their diagnosis.Materials and methods. The study involved 3,155 students aged 19.6 ± 1.5 years, of whom 46.9% were men and 53.1% were women. During the medical examination, all participants used a remote questionnaire screening.Results. A low degree of risk was detected in 57.4%, an average in 30.9%, and a high in 11.7% of the subjects. The patients with the highest frequency are concerned about complaints from the endocrine (28.9%), digestive (21.8%), respiratory (21.1%), cardiovascular (20.1%) and oncological alertness (8.1%). The presence of FR in two or more pathology profiles was determined in 75.7% of the examined patients. Among the most common FR are nine related to the self-assessment of the emotional and personal sphere. 96.6% of the surveyed and 91.7% of the medical staff are satisfied with the telemedicine system.Conclusions. 1. The use of remote questionnaire screening of HCNH provided wide coverage and high satisfaction with medical services. 2. The system allocates a contingent of subjects with high, medium and low risk, as well as people with critical disabilities in need of priority assistance. 3. The combination of data from anamnestic remote examination and clinical examination improves the quality of medical decision-making and reduces its subjective component. 4. The use of statistical methods has shown good effectiveness of the integrated assessment of health and satisfactory for the detection of chronic kidney disease. 5. The use of remote questionnaire screening of HRH in young people reduces treatment costs and improves the quality of life of patients.
Aprendizaje basado en problemas: una ruta para el desarrollo de competencias científicas en el laboratorio de química orgánica
Authors: Arrieta Palomino Jhajary Andrea , Hernández Barbosa Rubinsten , Casas Hinestroza José Luis 
Published: January 2025

El propósito de este escrito se centra en describir una ruta que resalta el valor didáctico de la estrategia Aprendizaje Basado en Problemas para el desarrollo de competencias científicas. Se desarrolló con estudiantes de la Licenciatura en Ciencias Naturales y Educación Ambiental de la Universidad Pedagógica y Tecnológica de Colombia, en la asignatura de química orgánica, específicamente en las prácticas de laboratorio. La experiencia se fundamentó desde la investigación cualitativa, que se caracteriza por ser inductiva, descriptiva e interpretativa; para recabar información, además de la observación, se usaron guías, cuestionarios y matrices de evaluación. Los resultados permiten señalar que se favoreció, entre otras cosas, el fomento y desarrollo de competencias científicas, ya que la problemática, aspecto central de la estrategia, abre caminos para activar conocimientos previos, posibilita la generación de hipótesis, como también permite reconocer lo que se requiere para resolver el problema para proponer un plan de trabajo guiado por los docentes, en cuyo proceso es necesario la toma de decisiones argumentadas. La evaluación realizada por los estudiantes reconoce la potencia de la estrategia, pero también señala aspectos que pueden ser reconfigurados para próximos trabajos como mayor tiempo para el desarrollo de las actividades.
Konwencjonalne modele scenariusza filmowego i ich kulturowe modyfikacje
Authors: Błaszczok Adam 
Published: January 2025

Celem przedstawionego artykułu jest ukazanie – ze szczególnym uwzględnieniem punktu widzenia praktyki branżowej – różnic w podejściu twórców europejskich i amerykańskich do zagadnienia wykorzystywania w produkcji filmowej konwencjonalnych modeli scenariuszy filmowych. Zdaniem autora publikacji funkcjonujące w tym obszarze odmienne praktyki wynikają z kilku zasadniczych przyczyn, do których można zaliczyć przede wszystkim różnice kulturowe i społeczne – co bezpośrednio wpływa na inne podejście do problemu finansowania produkcji filmowej. Wskazane zostały tendencje rozwojowe w scenopisarstwie europejskim i amerykańskim, wynikające z jednej strony z istniejących procesów globalizacyjnych i technologicznych, z drugiej zaś z pojawiających się w branży filmowej ruchów odśrodkowych. Scharakteryzowano konwencjonalne modele stosowane w produkcji filmowej z uwzględnieniem obu omawianych obszarów. Omówiono wybrane filmy reprezentatywne dla przedstawianego zagadnienia. Wykazano, że amerykański system produkcji filmowej przeważa nad europejskim zarówno pod względem organizacyjnym, jak też ze względu na poziom profesjonalizacji. Jednocześnie zwrócono uwagę na przyspieszenie procesów globalizacyjnych w branży filmowej, które są czynnikami determinującymi zmiany zarówno w Europie, jak i w Stanach Zjednoczonych.
α-Phellandrene: A Promising Natural Remedy for Rotenone-Induced Parkinson's Disease
Authors: Kumar Ravi , Arora Swamita , Alam Sanjar , Rashid Mohammad , Kumar Shivendra 
Published: January 2025

Abstract:
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the pro-gressive loss of dopaminergic neurons in the substantia nigra, leading to motor dysfunction and non-motor symptoms. Current treatments primarily offer symptomatic relief without halt-ing disease progression. This has driven the exploration of natural compounds with neuropro-tective properties. In previous studies, α-phellandrene, a monoterpene present in essential oils of various aromatic plants, has shown promise in mitigating neurodegenerative processes. This study focuses on alpha-phellandrene's therapeutic potential in a rotenone-induced Parkinson's Disease model. Rotenone, a mitochondrial complex I inhibitor, is commonly used to induce PD-like symptoms in experimental models due to its ability to mimic the neurodegenerative processes observed in human PD. Our review explores the neuroprotective effects of alpha-phellandrene, focusing on its antioxidant, anti-inflammatory, and anti-apoptotic properties. Experimental groups of rodents received rotenone to induce PD-like symptoms, followed by alpha-phellandrene treatment. Biochemical analyses were performed to measure oxidative stress markers, inflammatory cytokines, and apoptotic signals in brain tissues. Results indi-cated that alpha-phellandrene administration significantly improved motor function and re-duced rotenone-induced oxidative stress, inflammation, and apoptosis in dopaminergic neu-rons. Histopathological examinations revealed a notable preservation of neuronal integrity in alpha-phellandrene-treated groups compared to controls. In conclusion, alpha-phellandrene demonstrates considerable neuroprotective effects in a rotenone-induced Parkinson's dmodel. These findings suggest that alpha-phellandrene could be a promising natural therapeutic agent for PD, warranting further investigation into its mechanisms of action and potential clinical applications. Specifically, our review indicates that alpha-phellandrene may exert neuropro-tective effects by various mechanisms, such as reducing oxidative stress, modulating neuro-transmitter levels, or inhibiting neuroinflammation. These mechanisms highlight its potential to alleviate PD symptoms and slow disease progression, underscoring the need for in-depth studies to validate these therapeutic effects in clinical settings