bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive value of placental growth factor combined with uterine ultrasound arterial blood flow characteristics for preeclampsia
Authors: Xiao Fengmei , Li Caiqiu , Wang Xiaoying , Li Jun 
Published: January 2025

Objective: To study the predictive value of placental growth factor (PLGF) combined with uterine ultrasound artery blood flow characteristics in preeclampsia (PE).
Methods: The retrospective cohort study included singleton pregnant women who admitted for prenatal examinations at the Yongkang First People’s Hospital between February 2021 to November 2023. Based on whether the pregnant women had PE and the severity of PE, they were divided into Control group, Severe PE group and Mild PE group. Levels of PLGF and ultrasound arterial blood flow parameters were compared between the groups, and the sensitivity and specificity of the above indicators were calculated.
Results: This study included one hundred pregnant women with PE in the analysis, with 29 in the Severe PE group and 71 in the Mild PE group. Additionally, 100 healthy pregnant women without PE were included in the control group. Levels of PLGF, resistance index (RI), pulsatility index (PI), and systolic/diastolic blood flow ratio (S/D) were statistically different between the groups (P<0.05). Logistic analysis showed that PLGF, RI, PI, and S/D were risk factors for the onset of PE (P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the combined prediction value of PLGF, RI, PI, and S/D for PE was significantly higher than the individual prediction of each indicator (P<0.05).
Conclusions: PE was significantly associated with decreased levels of PLGF and increased RI, PI, and S/D in pregnant women. These indexes can serve as important indicators for predicting the onset of preeclampsia, especially when they are combined.
doi: https://doi.org/10.12669/pjms.41.2.11349
How to cite this: Xiao F, Li C, Wang X, Li J. The predictive value of placental growth factor combined with uterine ultrasound arterial blood flow characteristics for preeclampsia. Pak J Med Sci. 2025;41(2):426-431. doi: https://doi.org/10.12669/pjms.41.2.11349
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Trichinella spiralis excretory/secretory proteins mediated larval invasion via inducing gut epithelial apoptosis and barrier disruption
Authors: Lu Qi Qi , Zheng Wen Wen , Zhang Zhao Yu , Cong Pei Kun , Guo Xin , Zhang Yao , Zhang Xin Zhuo , Long Shao Rong , Liu Ruo Dan , Wang Zhong Quan , Cui Jing 
Published: January 2025

Background
Intestinal larva invasion is a crucial step of Trichinella spiralis infection. Intestinal infective larvae (IIL) and their excretory/secretory proteins (ESP) interact with gut epithelium, which often results in gut epithelium barrier injuries. Previous studies showed when T. spiralis invaded intestinal epithelium cells, the IIL ESP disrupted the tight junctions (TJs) of Caco-2 monolayer, but the mechanism is not clear. The IIL ESP might cause gut epithelial apoptosis, weaken the gut barrier and aid the larval invasion. The aim of this study was to investigate whether T. spiralis IIL ESP participate in enterocyte apoptosis and disrupt gut epithelial barrier to promote the larval invasion.

Methodology/Principal findings
Cell viability was assessed by CCK-8 assay and the results showed that 200 μg/ml of IIL ESP incubated with Caco-2 cells for 18 h inhibited the Caco-2 cell viability. The results of trans-epithelial electrical resistance (TEER) and FITC-dextran showed that IIL ESP decreased the TEER, increased FITC-dextran flux in Caco-2 monolayer. qPCR, Western blot and immunofluorescence test (IFT) showed that IIL ESP decreased the mRNA and protein expression of TJs (ZO-1, E-cad, Occludin and Claudin-1). The IIL ESP-induced Caco-2 cell apoptosis was observed by DAPI, Hoechst 33358, TUNEL and Annexin V/PI staining. Besides, flow cytometry revealed an increasing apoptosis rate in Caco-2 cells after the IIL ESP treatment. qPCR and Western blot analysis indicated that IIL ESP activated caspases (Caspase 3, Caspase 9 and Caspase 8), up-regulated the pro-apoptotic factors (Bax and Cytochrome c) and down-regulated the anti-apoptosis molecule Bcl-2. Interestingly, pretreatment of Caco-2 cells with apoptosis inhibitor Z-VAD-FMK abrogated and recovered the barrier function of Caco-2 monolayer destroyed by IIL ESP. Furthermore, the Z-VAD-FMK pretreatment also impeded the in vitro larva invasion of Caco-2 monolayer.

Conclusions
T. spiralis IIL ESP induced gut epithelial apoptosis, reduced the TJs expression, damaged gut epithelial integrity and barrier function, and promoted larval invasion. These findings provided a basis of further understanding the interaction mechanism between T. spiralis and host gut epithelium, and they were valuable to the development new prevention and therapeutic strategy of early T. spiralis infection.
A superior tool for predicting sepsis in SAH patients: The nomogram outperforms SOFA score
Authors: Yu Lei , Zou Shan , Zhou Qingshan , Cheng Beibei , Jin Jun 
Published: January 2025

Objective
This study aimed to develop and validate a nomogram to predict the risk of sepsis in non-traumatic subarachnoid hemorrhage (SAH) patients using data from the MIMIC-IV database.

Methods
A total of 803 SAH patients meeting the inclusion criteria were randomly divided into a training set (563 cases) and a validation set (240 cases). Independent prognostic factors were identified through forward stepwise logistic regression, and a nomogram was created based on these factors. The discriminative ability of the nomogram was assessed using the area under the receiver operating characteristic curve (AUC) and compared with the SOFA score. The model’s consistency was evaluated using the C-index, and the improvement in performance over the SOFA score was calculated using integrated discrimination improvement (IDI) and net reclassification improvement (NRI).

Results
Five independent predictive factors were identified through LASSO regression analysis: mechanical ventilation, hyperlipidemia, temperature, white blood cell count, and red blood cell count. The AUC of the nomogram in the training and validation sets were 0.854 and 0.824, respectively, both higher than the SOFA score. NRI and IDI results indicated that the nomogram outperformed the SOFA score in identifying sepsis risk. Calibration curves and the Hosmer-Lemeshow test demonstrated good calibration of the nomogram. Decision curve analysis showed that the nomogram had higher net benefit in clinical application.

Conclusion
The nomogram developed in this study performed excellently in predicting the risk of sepsis in SAH patients, surpassing the traditional SOFA scoring system, and has significant clinical application value.
Secret Violences: The Political Cinema of Michelangelo Antonioni 1960–1975, Sławomir Masłoń (2023)
Authors: Benci Jacopo 
Published: January 2025

Review of: Secret Violences: The Political Cinema of Michelangelo Antonioni 1960–1975, Sławomir Masłoń (2023)
New York and London: Bloomsbury Academic, 185 pp.,
ISBN 978-1-50139-823-0, h/bk, £81.00
Wandering Women: Urban Ecologies of Italian Feminist Filmmaking, Laura Di Bianco (2023)
Authors: Benini Stefania 
Published: January 2025

Review of: Wandering Women: Urban Ecologies of Italian Feminist Filmmaking, Laura Di Bianco (2023)
Bloomington, IN: Indiana University Press, 215 pp.,
ISBN 978-0-25306-464-6, p/bk, $25.00
Metastatic pheochromocytoma in multiple endocrine neoplasia type 2A
Authors: Rebrova D. V. , Rusakov V. F. , Krasnov L. M. , Fedorov E. A. , Chinchuk I. K. , Vorokhobina N. V. , Shikhmagomedov S. S. , Semenov A. A. , Chernikov R. A. , Sleptsov I. V. , Gavton G. I. , Imyanitov E. N. 
Published: January 2025

Pheochromocytoma (PHEO) currently is considered to be malignant due to metastatic potential. One of the most common familial forms of PHEO is multiple endocrine neoplasia syndrome (MEN) type 2. The penetrance of PHEO in MEN2 syndrome is up to 50% of cases. It may be one- or two-sided, but metastases occur extremely rare. The fact that in majority of cases of MEN2 syndrome the source of distant metastases is medullary thyroid carcinoma (MTC) complicates differential diagnosis in case of PHEO metastasis.Isolated cases of PHEO with metastases to the lymph nodes, lungs, liver, bones, brain in MEN2 patients were described. In the available literature, we have found a description of 31 cases of metastatic PHEO in MEN2 syndrome. The available data of those cases is presented as a table in the article.We present a description of a 40-year-old woman with MEN2A syndrome (mutation of the RET proto-oncogene p.Cys634Tyr), with a history of twice-performed surgical treatment of MTC, with daily crises of arterial hypertension accompanied by vegetative symptoms, with a giant bilateral PHEO (up to 200 m on the right and up to 150 mm on the left) with synchronous large metastasis (up to 50 mm) into the pubic bone with the destruction. The patient underwent several surgeries: bilateral adrenalectomy, then a bilateral revision of the neck, removal of the right upper and right lower parathyroid glands, residual thyroid tissue, then resection of the right pubic bone with a tumor.
SEGURANÇA ALIMENTAR E NUTRICIONAL: UMA ANÁLISE SOBRE O ARCABOUÇO LEGISLATIVO DOS ESTADOS BRASILEIROS
Authors: Costa Ana Paula Vieira da , Gabriel Cristine Garcia , Soar Claudia , Machado Mick Lennon , Martins Milena Correa , Lima Giovana Felício 
Published: January 2025

Para garantir a efetiva descentralização do Sistema Nacional de Segurança Alimentar e Nutricional faz necessário o envolvimento das distintas esferas governamentais. Objetivo: Mapear o arcabouço legal que dispõe sobre a segurança alimentar e nutricional nos estados. Métodos: Estudo descritivo, exploratório e documental com coleta de normativas publicadas pelas 26 unidades federativas. Os documentos foram categorizados com base nas diretrizes da Política Nacional de Segurança Alimentar e Nutricional. Resultados: Foram incluídas 407 normativas para análise. O estudo identificou uma discrepância regional na elaboração das normativas, sendo a região Norte (7%) a que menos legislou na área, seguida respectivamente das regiões Sul (13%), Centro-Oeste (20%), Nordeste (26%) e Sudeste (32%). As dimensões mais abordadas foram respectivamente “Promoção do Acesso Universal à Alimentação Adequada” (54%); “Estruturação de Sistemas de Produção Agroecológica e Abastecimentos Sustentáveis” (32%) e “Estruturação do Sistema Nacional de Segurança Alimentar e Nutricional” (20%). A Dimensão “Acesso Universal à Água” apresentou o menor resultado (8%). Conclusão: O estudo revelou um cenário de disparidades regionais no que concerne à elaboração de legislações nesta área. Sugere-se a realização de estudos que analisem em profundidade as normativas e que considerem as distintas realidades existentes entre as regiões e as unidades federativas brasileiras.
The Effect Of Financial Performance, Environmental Performance, Tax Avoidance, And Gender Diversity On Sustainable Development Goals (SDGs)
Authors: Novita Ayu Amalikhah  , Slamet Haryono  
Published: January 2025

The purpose of this study is to determine the influence of financial performance, environmental performance, tax avoidance, and gender diversity on sustainable development goals (SDGs). Based on the background and after deepening the literature, the researcher found a research gap from previous research that examined the relationship between the Company and the SDGs. Until now, research that connects the influence of financial, environmental, and diversity factors on achieving the SDGs is still minimal. Therefore, this study aims to analyze the influence of the current ratio, free cash flow, environmental performance, tax avoidance, and gender diversity in the board on the company's contribution to supporting the SDGs goals. This research is expected to contribute to academic literature and business practices related to the role of companies in sustainable development.
This study uses a quantitative approach. The population in this study is all companies listed in the DES (Sharia Securities List) that have annual reports and sustainability reports for the 2021-2023 period. The sampling technique used in this study is purposive sampling. The sample in this study is 70 companies. The data collection technique in this study is using documentation techniques. The hypothesis test in this study uses the formula 1) T-test, 2) F-test, and 3) Determination Coefficient Test.
Based on the results of the data analysis processed and the discussion that has been described by the researcher, the following conclusions are reached: 1) The current ratio of companies has a positive effect on the SDGs. This is because companies that show greater liquidity and profitability tend to have the necessary resources to support the SDGs. 2) Free cash flow does not influence the SDGs. This can happen because free cash flow only shows the availability of funds, and how the funds are used. 3) Environmental performance has a positive effect on the SDGs. This can happen because by increasing environmental performance, companies can help support the global goals (SDGs) related to environmental sustainability. 4) Tax avoidance carried out by companies will hurt the SDGs. This is because taxes are one of the largest revenues owned by the state. 5) Board gender diversity has a positive influence on the SDGs. This happens because the level of equality in the board can encourage an inclusive work culture and will have an impact on company productivity.
Erstellung eines Moodle-Selbstlernkurses zur Recherche- und Informationskompetenz an der Universitätsbibliothek Wien: ein Werkstattbericht
Authors: Fiala Sonja 
Published: January 2025

Zusammenfassung
In diesem Werkstattbericht wird die Erstellung eines Moodle-Selbstlernkurses zur Recherche- und Informationskompetenz an der Universitätsbibliothek Wien beschrieben. Die Plattform Moodle wird von der Universität Wien für die Organisation aller Lehrveranstaltungen genutzt. Dem Wunsch der Studierenden nach übersichtlicher Erstinformation zur Bibliotheksbenutzung wurde mit diesem Selbstlernkurs entsprochen. Die Erstellung erfolgte als abteilungsübergreifendes Projekt und wurde mit aktuellen Online-Tools realisiert.
Loblolly pine downed timber: Box-Behnken design and first derivative pretreatment for predictive modeling with near-infrared spectroscopy and machine learning (NIRS-ML)
Authors: Hernandez-Diaz Javier A. , Musah Munkaila , Bello Fatimatu , Via Brian , Peresin Maria S. 
Published: January 2025

Abstract
This study developed wood composition analysis by integrating nonlinear techniques, the first derivative as a mathematical pretreatment, and a Box-Behnken design to reduce the sample size for predictive models in downed timber characterization. Utilizing 15 out of 176 core samples subjected to a year of natural degradation, models exhibited comparable efficiency to full set models reported in the literature. Spectral pretreatment highlighted the efficacy of the first derivative and smoothing, achieving a balanced distribution of explained variance. Support vector machines (SVM) models, particularly the polynomial kernel, demonstrated competitive performance compared with other reports in the literature. Coefficients of determination (R
2) and root mean square errors (RMSEC and RMSEP), revealed the performance of the cellulose, hemicellulose, and lignin models. The cellulose model exhibited the best performance, followed by hemicellulose and lignin. The best-performing kernel was the polynomial kernel with R
2 values of 0.92, 0.77, and 0.74 (cellulose, hemicellulose, and lignin, respectively). The RMSEC were 1.21, 0.94, and 1.43, respectively. The RMSEP were 2.22, 1.31, and 0.47, respectively. Utilizing a reduced sample size and spectral pretreatment yielded competitive results, showcasing its potential for efficient wood composition prediction. These findings open avenues for streamlined, resource-efficient wood characterization, with implications for biorefineries and the circular economy.
The potential of generative AI with prostate-specific membrane antigen (PSMA) PET/CT: challenges and future directions
Authors: Islam Md Zobaer , Spiro Ergi , Yap Pew-Thian , Gorin Michael A. , Rowe Steven P. 
Published: January 2025

Abstract
The diagnosis and prognosis of Prostate cancer (PCa) have undergone a significant transformation with the advent of prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging. PSMA-PET imaging has demonstrated superior performance compared to conventional imaging methods by detecting PCa, its biochemical recurrence, and sites of metastasis with higher sensitivity and specificity. That transformation now intersects with rapid advances in artificial intelligence (AI) – including the emergence of generative AI. However, there are unique clinical challenges associated with PSMA-PET imaging that still need to be addressed to ensure its continued widespread integration into clinical care and research trials. Some of those challenges are the very wide dynamic range of lesion uptake, benign uptake in organs that may be adjacent to sites of disease, insufficient large datasets for training AI models, as well as artifacts in the images. Generative AI models, e.g., generative adversarial networks, variational autoencoders, diffusion models, and large language models have played crucial roles in overcoming many such challenges across various imaging modalities, including PET, computed tomography, magnetic resonance imaging, ultrasound, etc. In this review article, we delve into the potential role of generative AI in enhancing the robustness and widespread utilization of PSMA-PET imaging and image analysis, drawing insights from existing literature while also exploring current limitations and future directions in this domain.
Single-step fabrication of Ag2S/poly-2-mercaptoaniline nanoribbon photocathodes for green hydrogen generation from artificial and natural red-sea water
Authors: Aldosari Eman , Rabia Mohamed , Sanna Aimaro , Farid Osama 
Published: January 2025

Abstract
A novel and highly promising Ag2S-P2MA nanoribbon photocathodes are synthesized using a single-step technique based on 2-mercaptoaniline oxidation with (NH4)2S2O8 and AgNO3. This process yields polymer composites with nanoribbon morphologies, typically 150 nm wide and ranging from 500 to 1,000 nm in length. These nanoribbons exhibit excellent absorbance across the entire optical spectrum up to 780 nm. The fabricated Ag2S/P2MA photocathode is designed for water splitting to generate hydrogen gas using two different electrolytes: natural Red Sea water and artificial seawater free from heavy metals. This variation allows observation of the impact of seawater’s heavy metals. Hydrogen gas production is studied using a three-electrode cell with linear sweep voltammetry at room temperature. In both electrolytes, the photocurrent is measured at 0.015 mA/cm2. However, both the current density in light (J
ph) and dark (J
o) values decrease in artificial seawater compared to natural seawater, with values of −0.033 and −0.017 mA/cm2 in natural seawater and −0.027 and −0.012 mA/cm2 in artificial seawater. The Ag2S-P2MA nanoribbon photocathodes exhibit stable behavior, producing hydrogen at a rate of 12 µmol/cm2 h. Combined with their cost-effectiveness and potential for mass production, this positions them as viable candidates for commercial electrode applications in various industrial settings.
Thermal annealing and microwave irradiation in enhancing the mechanical performance of 3D printing CF/PA12 composite
Authors: Zhang Huifang , Zhi Jieying , Lu Xiaoxuan , Gao Xiaoqing , Sun Youyi , Yang Yu 
Published: January 2025

Abstract
3D printing polymers and their composites have shown considerable potential in various application fields, yet their limited mechanical properties have hindered widespread use in structural materials. Recently, postprocessing techniques have been proposed as efficient and convenient methods to enhance the mechanical properties of 3D printing structures. This study systematically investigates the effects of thermal annealing and microwave irradiation on the microstructure and mechanical properties of 3D printing carbon fiber reinforced polyamide 12 (CF/PA12). The results clearly demonstrate that thermal annealing significantly outperforms microwave irradiation in improving fiber–matrix interfacial adhesion and crystallization. Specifically, thermal annealing provides necessary time for molecular chain relaxation, effectively releasing internal stresses. Additionally, thermal annealing optimizes the transcrystalline structure at the fiber–matrix interface and the volume fraction of crystalline regions within the matrix. Compared to the pristine samples, the annealed 3D printing specimens exhibited increases of 19.34 % in tensile strength and 27.11 % in flexural strength. This research provides an in-depth insight into enhancing 3D printing CF/PA12 composites through postprocessing techniques and offers a scientific basis for their large-scale application.
Atuação em psicologia hospitalar na pandemia da covid-19: revisão integrativa de literatura
Authors: Telles Maria Laura de Freitas Andrade , Pegoraro Renata Fabiana 
Published: January 2025

A pandemia da Covid-19 acarretou, além de mortes e hospitalizações, impactos psicológicos negativos para a população e comunidade da saúde. A alta transmissibilidade do vírus, ansiedade devido isolamento e medo da morte foram vivências experienciadas com maior intensidade por pacientes hospitalizados, familiares e trabalhadores da linha de frente do cuidado. Diante disso, os psicólogos que atuam na assistência hospitalar receberam uma larga demanda de cuidado e suas ferramentas de trabalho exigiram adaptação para o novo cenário, marcado pela redução de contato físico. O objetivo deste artigo foi mapear as estratégias utilizadas por psicóloga/os hospitalares durante a pandemia da Covid-19. Para isso, foi feita uma revisão integrativa de literatura, onde foram selecionados 14 artigos publicados entre 2020 e 2023, do tipo relato de experiência, a partir das bases de dados online BVS, Capes, PePSIC e Google Acadêmico, com os descritores “psicologia hospitalar”, “Covid-19” e “relato”. Os resultados destacam ações que envolvera comunicação remota e atividades presenciais, e dificuldades encontradas na prática da psicologia hospitalar, como a sobrecarga de trabalho e falta de conhecimento específico sobre o vírus. Observou-se que, apesar de as estratégias presenciais serem mantidas a partir dos protocolos de biossegurança, o uso de tecnologias foi utilizado com frequência para teleatendimentos, acolhimento online, plantões de atendimento psicológico remoto e visitas virtuais. Nota-se a importância de ações educativas e promoção de saúde mental aos profissionais de saúde afim de garantir desempenho eficaz. As estratégias adotadas durante a pandemia se mostraram valiosas, podendo desempenhar importante função enquanto medidas permanentes.