bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of miR‐578 through SOCS2‐dependent manner reverses gefitinib resistance in NSCLC cells
Authors: Yang Bo , Yao Lei , Yang Liankai , Zhao Fang , Zhou Wenyan 
Published: November 2023

AbstractBackgroundNonsmall‐cell lung cancer (NSCLC) has emerged as one of the dreadful lung cancers globally due to its increased mortality rates. Concerning chemotherapy, gefitinib has been employed as an effective first‐line treatment drug for NSCLC. Nonetheless, the acquired resistance to gefitinib has remained one of the treatment obstacles of NSCLC, requiring improvement in the therapeutic effect of gefitinib.MethodsInitially, reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR), and Western blotting (WB) analyses were conducted to measure micro‐ribose nucleic acid (miRNA, specifically miR‐578) and suppressor of cytokine signaling 2 (SOCS2) levels in the clinical samples. Further, NSCLC cell lines resistance to gefitinib, established in vitro, were transfected by miR‐578 inhibitor, miR‐578 mimic, and si‐SOCS2. Similarly, the xenograft mouse model in vivo was constructed to validate the reversing effect of miR‐578.ResultsOur findings indicated the increased miR‐578 expression levels in the gefitinib resistance group. Further, inhibiting the miR‐578 expression substantially reversed the gefitinib resistance. In addition, the miR‐578 effect was modulated via the SOCS2 expression level. The decreased gefitinib resistance effect of miR‐578 was weakened by inhibiting the SOCS2 expression.ConclusionThese findings demonstrated that miR‐578 effectively abolished gefitinib resistance by regulating the SOCS2 expression within NSCLC cells in vitro and in vivo. Together, these results will undoubtedly support a reference to provide potential molecular therapeutic targets and clinical treatments for treating NSCLC patients.
Pb(NO3)2 induces cell apoptosis through triggering of reactive oxygen species accumulation and disruption of mitochondrial function via SIRT3/SOD2 pathways
Authors: Lin Hui‐Wen , Lee Hsiang‐Lin , Shen Ting‐Jing , Ho Meng‐Ting , Lee Yi‐Ju , Wang Inga , Lin Ching‐Pin , Chang Yuan‐Yen 
Published: November 2023

AbstractLead (Pb) is nonbiodegradable and toxic to the lungs. To investigate the potential mechanisms of Pb‐induced reactive oxygen species (ROS) accumulation and cell death in the lungs, human non‐small lung carcinoma H460 cells were stimulated with Pb(NO3)2 in this study. The results showed that Pb(NO3)2 stimulation increased cell death by inducing cell apoptosis which showed a reduced Bcl‐2 expression and an enhanced caspase 3 activation. Pb(NO3)2 also caused the production of H2O2 in H460 cells that triggering the buildup of ROS and mitochondrial membrane potential loss. We found that Pb(NO3)2 modulates oxidoreductive activity through reduced the glutathione‐disulfide reductase and glutathione levels in Pb(NO3)2‐exposed H460 cells. Furthermore, the superoxide dismutase (SOD) upstream molecule sirtuin 3 (SIRT3) was increased with Pb(NO3)2 dose. Collectively, these results demonstrate that Pb(NO3)2 promotes lung cell death through SIRT3/SOD‐mediated ROS accumulation and mitochondrial dysfunction.
Indigenous Knowledge and Perspectives
Authors: Bocking Stephen 
Published: November 2023

AbstractIndigenous knowledge, once dismissed as mere folklore, is now widely recognized as an essential dimension of global environmental knowledge. Indigenous people, once excluded, now participate across a range of environmental affairs. Understanding how and why this has occurred requires attention to a complex history of scientists and others constructing ideas about Indigenous knowledge. A variety of scholars, including historians of science, environmental historians, and political ecologists have examined this history, identifying the factors that have influenced expert, public, and institutional perceptions of Indigenous knowledge. These include various colonial and postcolonial contexts, ideas about development, changes in the natural environment, disciplinary perspectives (such as those of anthropology), and shifting views of human-environment relations. Indigenous peoples – as knowledge producers, brokers, and intermediaries – have been crucial to these evolving perceptions, by asserting that their knowledge can be a means of achieving change in both knowledge and politics. The Arctic provides a distinctive setting in which the historical construction of Indigenous knowledge can be examined in more detail.
Holistic Analysis of Organised Misinformation Activity in Social Networks
Authors: Peñas Anselmo , Deriu Jan , Sharma Rajesh , Valentin Guilhem , Reyes-Montesinos Julio 
Published: November 2023

AbstractTo tackle the problem of disinformation, society must be aware not only of the existence of intentional misinformation campaigns, but also of the agents that introduce the misleading information, their supporting media, the nodes they use in social networks, the propaganda techniques they employ and their overall narratives and intentions. Disinformation is a challenge that must be addressed holistically: identifying and describing a disinformation campaign requires studying misinformation locally, at the message level, as well as globally, by modelling its propagation process to identify its sources and main players. In this paper, we argue that the integration of these two levels of analysis hinges on studying underlying features such as disinformation’s intentionality, and benefited and injured agents. Taking these features into account could make automated decisions more explainable for end users and analysts. Moreover, simultaneously identifying misleading messages, knowing their narratives and hidden intentions, modelling their diffusion in social networks, and monitoring the sources of disinformation will also allow a faster reaction, even anticipation, against the spreading of disinformation.
Structural and mechanical evaluation of a new Ti-Nb-Mo alloy produced by high-energy ball milling with variable milling time for biomedical applications
Authors: Dahmani Marwa , Fellah Mamoun , Hezil Naouel , Benoudia Mohamed-Cherif , Abdul Samad Mohammed , Alburaikan Alhanouf , Abd El-Wahed khalifa Hamiden , Obrosov Aleksei 
Published: November 2023

AbstractThe main focus of this work is to investigate the impact of varying milling times (2 to 18 h) on the structural and mechanical properties of the developed Ti-Nb-Mo alloy. The morphology, phase composition, microstructure, and mechanical behavior of milled and sintered Ti-25Nb-25Mo alloy samples were characterized systematically using x-ray diffraction, scanning electron microscope, optical microscope, and Vicker microhardness. It was noted that the quantity of the β-Ti phase increased as the milling time increased. After 12 h of milling, the synthesized alloys exhibited a spherical morphology and texture with homogeneous distribution. The milled alloys' structural evolution and morphological changes were found to be dependent on their milling duration. Morphological analysis revealed that the crystallite size and mean pore size decreased when the milling duration increased, reaching minimum values of 51 nm and < 1 μm, after 12 and 18 h respectively. As the milling time increased, the grain size decreased, resulting in an increase in density, microhardness, and elastic modulus. Ti-25Nb-25Mo will presents good anti-wear ability and higher resistance to plastic deformation due to enhanced mechanical characteristics (H/E, and H3/E2). Hence, the developed Ti-25Nb-25Mo alloys with reduced elastic modulus and desirable mechanical properties were found to be a promising option for biomedical applications.
Biomarker array for prediction of acute kidney injury after percutaneous coronary intervention for patients who had acute ST segment elevation myocardial infarction
Authors: Alkassas Amr , Elbarbary Yasser , Sherif Mohammed H. , El-Saied Shaimaa B. , Hagag Rasha Y. , Elbarbary Mohammed 
Published: November 2023

AbstractAcute kidney injury (AKI) is a common complication after Percutaneous Coronary Intervention (PCI) for ST segment elevation myocardial infarction (STEMI) and is associated with poor outcomes. AKI is diagnosed by the dynamic change of serum Cr, but it could not predict AKI. This study aimed to evaluate a biomarker array that may fulfill this shortage. Setting: Cardiology Department, Tanta University Hospital. Design: Prospective interventional study included 280 acute STEMI patients who underwent emergency PCI. Serial samples of blood and urine were obtained at the time of admission to the hospital (T0) and PCI unit (T1) and at 12 h and 72 h (T12 and T72) after coronary revascularization to estimate levels of serum Cr, creatine phosphokinase, and heart-type fatty acid-binding protein (H-FABP) and calculation of neutrophil/lymphocyte ratio (NLR) and urinary liver-type FABP (L-FABP). AKI was diagnosed according to the recommendations of the European Renal Best Practice as the times of increased serum Cr concerning baseline level. 85 patients developed AKI. Regression analyses defined a high NLR ratio in the T0 sample as the most significant predictor for early AKI diagnosed at T1 time, while high NLR and serum H-FABP levels in T1 samples as the significant predictors for AKI defined at T12 time. However, high urinary L-FABP levels in T12 samples and high NLR are significant predictors for AKI at T72 time. Combined estimations of serum H-FABP and urinary L-FABP with the calculation of NLR could predict the oncoming AKI and discriminate its pathogenesis. The study protocol was approved by the Local Ethical Committee at Tanta Faculty of Medicine by approval number: 35327/3/22. For blindness purposes, the authors will be blinded about the laboratory results till the end of 72 h after revascularization and the clinical pathologist will be blinded about the indication for the requested investigations.
Virtual coach and telerehabilitation for Parkinson´s disease patients: vCare system
Authors: Del Pino Rocio , de Echevarría Amaia Ortiz , Díez-Cirarda Maria , Ustarroz-Aguirre Iker , Caprino Massimo , Liu Jin , Gand Kai , Schlieter Hannes , Gabilondo Iñigo , Gómez-Esteban Juan Carlos 
Published: November 2023

Abstract
Aim
The vCare system is a virtual coach that involves physical and cognitive telerehabilitation and a daily life monitoring system. This pilot study aims to evaluate the vCare pilot test for Parkinson’s disease (PD) patients and to analyze the usability and the satisfaction level of patients and their quality of life (QoL).

Subject and methods
Twenty PD patients were randomized, 10 patients into the vCare group focused on personalized home telerehabilitation [motor and cognitive rehabilitation (4 days/week for 4 months)], while the control group (10 patients) continued the clinical standard at the clinic. A pre-post clinical evaluation and a cost-utility study were performed.

Results
Repeated measures ANOVA showed significant improvement in the PD vCare group compared to the control group (p<.05). Specifically, the PD vCare group showed significant improvement in cognition (p=.016), and QoL dimensions of mobility (p=.008), self-care (p=.008), daily activities (p=.010) and pain/discomfort (p=.004) at post-treatment. vCare PD patients showed high adherence to the vCare system (90.5-100%). Costs per patient in the control group were higher (€5,108.26) than in the vCare group (€2,243.07).

Conclusion
The PD vCare group significantly increase their QoL, cognition, motor symptoms, and daily life activities compared to the control group. Patients showed high adherence to the vCare coach, the care plan, rehabilitation, and devices. The vCare system seems to be an optimal and cost-effective tool for telerehabilitation in PD.
Photosensitive cellulosic materials based on a covalently grafted phenosafranin-modified silsesquioxane analog for bactericidal applications
Authors: Rozga-Wijas Krystyna , Ganicz Tomasz , Miksa Beata , Makowski Tomasz , Knopik Lucja , Turecka Katarzyna , Waleron Krzysztof 
Published: November 2023

AbstractLight-triggered antimicrobial cellulose surfaces were obtained by the immobilization of a photosensitive phenosafranin dye (PSF) in a hybrid organic–inorganic silsesquioxane polymer applied on handsheets prepared from a standard bleached softwood pulp. These coatings were deposited by polycondensation of methyltriethoxysilane and an alkoxysilyl derivative of phenosafranin (TESPSF) obtained by the thiolene addition reaction and coupling of the succinic anhydride derivative with a primary amine group of PSF. TESPSF and coatings were characterized by advanced techniques in terms of chemical structure (1H, 13C, 29Si NMR, MS, ATR-IR), surface properties (SEM, EDX, water contact angles), and optical properties (UV, reflection light intensity, ISO brightness). The light-induced antimicrobial activity of sheets of paper coated with new materials showed the inhibition of the growth of the bacteria Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 8739. The cytotoxicity studies of modified cellulose surfaces were performed using erythrocyte lysis assays under both dark and light conditions exhibited no toxicity on erythrocytes. Thus, the new material did not reveal harmful effects on erythrocytes, regardless of the presence and absence of light.
Being a Program Director in a Mental Health Training Program - A Candid Reflection
Authors: Williams Lee 
Published: November 2023

AbstractDespite the important impact that program directors can have upon a mental health training program, there is surprisingly little literature on program directors. This article builds on the existing literature by providing a candid insider’s perspective on what it is like to be a program director of a mental health training program. The article describes twelve areas where program directors may experience challenges, such as developing a leadership style, the potential impact on relationships (e.g., power), managing triangulation, addressing the impact of the role on teaching and scholarship, dealing with burnout, managing accreditation, and working with university administrators. In each of these areas, recommendations for how a program director might navigate these challenges are offered. The article concludes with a call for more research on this topic given the limited literature.
Anomaly detection in sleep: detecting mouth breathing in children
Authors: Biedebach Luka , Óskarsdóttir María , Arnardóttir Erna Sif , Sigurdardóttir Sigridur , Clausen Michael Valur , Sigurdardóttir Sigurveig Þ. , Serwatko Marta , Islind Anna Sigridur 
Published: November 2023

AbstractIdentifying mouth breathing during sleep in a reliable, non-invasive way is challenging and currently not included in sleep studies. However, it has a high clinical relevance in pediatrics, as it can negatively impact the physical and mental health of children. Since mouth breathing is an anomalous condition in the general population with only 2% prevalence in our data set, we are facing an anomaly detection problem. This type of human medical data is commonly approached with deep learning methods. However, applying multiple supervised and unsupervised machine learning methods to this anomaly detection problem showed that classic machine learning methods should also be taken into account. This paper compared deep learning and classic machine learning methods on respiratory data during sleep using a leave-one-out cross validation. This way we observed the uncertainty of the models and their performance across participants with varying signal quality and prevalence of mouth breathing. The main contribution is identifying the model with the highest clinical relevance to facilitate the diagnosis of chronic mouth breathing, which may allow more affected children to receive appropriate treatment.
An exploration of online technoliteracy capability teaching and learning in early years classrooms
Authors: Falloon Garry 
Published: November 2023

Abstract The increasing use of digital devices by young children, has led to calls for earlier teaching for information literacy. However, some research indicates reluctance to do this, due to perceived limitations of young children and notions about what is and is not ‘appropriate’ for them learn. This study examines this proposition, through analysis of 6 and 7 year olds’ application of ‘Technoliteracy’ capabilities during a unit of learning about Matariki (the Maori new year). It used an updated and expanded revision of Durrant and Green’s (2000) l(IT)eracy capability model, to understand how the students applied ‘Technoliteracy’ capabilities to online research and production of an information artefact for an identified audience. Although results were mixed, data was found of students’ productive engagement of ‘Technoliteracy’ capabilities aligned with Durrant and Green’s dimensions, suggesting that with developmentally-appropriate curriculum and pedagogy they were capable of integrating these for meaning making, judging meaning quality, and meaning sharing and communication. Given increasingly ubiquitous access to devices from a young age, results indicate that serious consideration should be given to teaching basic ‘Technoliteracy’ capabilities in early years classrooms.
Inequality of opportunity in educational achievement in Western Europe: contributors and channels
Authors: Marrero Gustavo A. , Palomino Juan C. , Sicilia Gabriela 
Published: November 2023

AbstractWe study the contribution of students’ circumstances to inequality of opportunity in educational achievement (IOpE) in Western Europe and explore the role of intermediate channelling variables in translating differences in circumstances into educational inequalities. Using the 2018 Programme for International Student Assessment (PISA) database, we find that differences in households’ cultural environment and in parental occupation are the most important contributing circumstances, with school’s circumstances being relevant mostly in Central Europe. Our results show that the relevant channels of IOpE in most countries are students’ educational and occupational expectations, their reading habits and skills, and grade repetition in previous years. These findings can provide policymakers with key insights to aid in designing educational interventions that effectively increase educational opportunities across European countries.
Novel Bio-based Branched Unsaturated Polyester Resins for High-Temperature Applications
Authors: Akbari Samira , Root Andrew , Skrifvars Mikael , Ramamoorthy Sunil Kumar , Åkesson Dan 
Published: November 2023

AbstractUnsaturated polyester resins, one of the most important thermosets, are invariably produced from oil-based monomers. Their application is limited in areas where high thermal stability is required due to their low Tg. Besides, these resins contain 30–40% hazardous styrene as a reactive solvent. Therefore, developing bio-based solventless unsaturated polyester resin with medium to high thermomechanical properties compared to petrochemical-based counterparts is important. In order to achieve this, a series of branched bio-based unsaturated polyester resins were synthesized using bulk polymerization method in two steps. In the first step, four different intermediates were prepared by reacting glycerol (as a core molecule) with either isosorbide (diol), 1,3-propanediol (diol), 2,5-furandicarboxylic acid (saturated diacid), or adipic acid (saturated diacid). In the second step, the branched intermediate was end capped with methacrylic anhydride to introduce reactive sites for cross-linking on the branch ends. The chemical structure of the resins was characterized by 13C-NMR. FT-IR confirmed the polycondensation reaction in the first step and the end functionalization of the resins with methacrylic anhydride in the second step. The effect of 2,5-furandicarboxylic acid and isosorbide on thermomechanical and thermal properties was investigated using dynamic mechanical analysis, differential scanning calorimetry, and thermo-gravimetric analysis. Results indicated that 2,5-furandicarboxylic acid based resins had superior thermomechanical properties compared to a commercial reference unsaturated polyester resin, making them promising resins for high-temperature composite applications. For example, the resin based on 2,5-furandicarboxylic acid and isosorbide and the resin based on 2,5-furandicarboxylic acid and 1,3-propanediol gave glass transition temperatures of 173 °C and 148 °C, respectively. Although the synthesized 2,5-furandicarboxylic acid based resins had higher viscosity (22.7 Pas) than conventional unsaturated polyester (0.4–0.5 Pas) at room temperature, preheated resins can be used for making high-temperature-tolerance fiber-reinforced composite.
Influence of Epoxidized Natural Rubber of the thermoformability of Poly(Lactic Acid) biopolymer films using elevated temperature ball burst tests
Authors: Tábi T. , Gere D. , Csézi G. , Pölöskei K. 
Published: November 2023

AbstractIn this paper, we investigated the thermoformability of Epoxidized Natural Rubber (ENR)-filled Poly(Lactic Acid) (PLA) films using elevated temperature tensile and ball burst tests. Three different d-Lactide contents of PLA were used to be able to analyze the effect of crystallization and crystallinity. We observed that the ENR acted as a nucleating agent in PLA when the blend was cooled from melt or cold crystallized, but it retarded the drawing-induced crystallization of PLA at elevated temperature tensile testing since ENR droplets acted as obstacles. The effect of NR on PLA crystallization was also found to be dependent on d-Lactide content. In the ball burst test, different behaviors were observed for PLA with the lowest d-Lactide content, which was caused by the complex stress state that even more induced crystallization of PLA and then a single-axis tensile test.
Epistemic Modality Constructions as Stable Idiolectal Features: A Cross-genre Study of Spanish
Authors: Mojedano Batel Andrea , Soler Bonafont Amparo , Kredens Krzysztof 
Published: November 2023

AbstractForensic authorship analysis is based on two assumptions: that every individual has a unique idiolect, and that features characteristic of that idiolect will recur with a relatively stable frequency. Yet, a speaker’s language can change with age, affective states, according to audience, or genre. Thus, studies on authorship analysis should adopt the theory that while some linguistic parameters of an idiolect can remain stable, others can change depending on various circumstances. This investigation, which takes a constructional and functional-based approach to discourse-level phenomena in idiolectal stability, analyzes cross-genre data produced by nine Mexican participants throughout a twelve-year time span. This study contributes to a greater understanding of the linguistic elements that survive genre effects and are potentially useful in both investigative and evidential forensic linguistic work. We provide a detailed description of linguistic features, their specific values, and context-dependent interpretation, keeping in mind the context of expert linguistic testimony, with its preference for methods which “employ linguistically motivated analyses in combination with quantitative tools” (Solan & Tiersma, 2004, p.463).Our findings show that idiolectal style tends to remain stable across genres and communication modes in epistemic modality constructions. Epistemic markers —specifically, markers indicating low commitment by the speaker (e.g., no sé ‘I don’t know’) or expressing indirectness when introducing the illocutionary force (e.g., la verdad [es que] ‘the truth [is that]’)— display idiolectal stability, as these markers seem to be the most effective in terms of allowing speakers to strategically manifest the extent of their knowledge regarding what is said.