bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Early Care (0–3 Years) In Duchenne Muscular Dystrophy Meeting Report
Authors: Armstrong Niki , Apkon Susan , Berggren Kiera N. , Braun Catherine , Ciafaloni Emma , Connolly Anne , Kennedy Annie , Kuntz Nancy , Mathews Katherine , McGuire Michelle , Parad Richard , Scavina Mena , Scharf Rebecca J. , Waldrop Megan 
Published: January 2024

Objective: This report summarizes the key discussions from the “Early Care (0–3 years) in Duchenne Muscular Dystrophy” meeting, which aimed to address the challenges and opportunities in the diagnosis and care of Duchenne muscular dystrophy (DMD) and female carriers within the 0–3-year age group. Methods: The meeting brought together experts and healthcare providers who shared insights, discussed advancements in DMD care, and identified research needs. Presentations covered diagnostic challenges, approved therapies, clinical trials, identification of young female carriers, and the importance of clinical care and support for families. Results: The meeting highlighted the importance of timely diagnosis and the lack of evidence-based guidelines for the care of children with DMD aged 0–3 years. Diagnostic challenges were discussed, including delays in receiving a DMD diagnosis and disparities based on ethnicity. The potential benefits and process of newborn screening were addressed. Approved therapeutic interventions, such as corticosteroids and exon-skipping drugs, were explored, with studies indicating the potential benefits of early initiation of corticosteroid therapy and the safety of exon-skipping drugs in DMD. Clinical trials involving infants and young boys were discussed, focusing on drugs like ataluren, vamorolone, and gene therapies. The meeting emphasized the importance of clinical care and support for families, including comprehensive information provision, early intervention services, and individualized support. The identification and care of young female carriers were also addressed. Conclusion: The meeting provided a platform for experts and healthcare providers to discuss and identify key aspects of early care for children with DMD aged 0–3 years. The meeting emphasized the need for early diagnosis, evidence-based guidelines, and comprehensive care and support for affected children and their families. Further research, collaboration, and the development of consensus guidelines are needed to improve early diagnosis, treatment, and outcomes in this population.
Srategi Pemasaran Syariah Produksi Keripik Pisang Pada Usaha Santri di Yayasan Al-Kamilah Depok
Authors: ZamZami R. Mohd , Sa'diyah Khotimatus , AN Wiwik Hasbiyah 
Published: January 2024

Pengabdian kepada masyarakat ini bermula dari belum terbangunnya ekonomi syariah secara maksimal khususnya di kota Depok. Hal ini bisa dilihat salah satunya dari pemasaran produk khususnya disektor kuliner dimana para pelaku usaha masih banyak yang belum mencantumkan label halal pada produknya. Pengabdian kepada masyarakat ini berfokus pada strategi pemasaran produk khususnya produk UMKM para santri yayasan Al-Kamilah, sehingga tujuannya yaitu bagaimana menerapkan strategi pemasaran yang tepat pada usaha yang dikelola oleh para santri, dan mengetahui model pengembangan santripreneur sebagai penggerak ekonomi kreatif berbasis syariah di Provinsi Depok khususnya di Yayasan Al-Kamilah. Pengabdian kepada masyarakat ini menggunakan metode penyuluhan dan wawancara. Hasil pengabdian kepada masyarakat ini berjalan lancardengan antusiasnya pertanyaan para peserta tentang pemasaran syariah berbasis inovasi dan kreatif untuk produk andalan UMKM di Yayasan Al-Kamilah yaitu produk keripik pisang kapok.
Експериментальне визначення зміни капілярної утримної здатності сітчастих розділювачів фаз
Authors: Minai Oleksandr 
Published: January 2024

The subject of this study is the process of loss of capillary holding capacity (CHC) as a result of a violation of the balance of external and internal forces on the phase interface (PI) "liquid - gas" of the capillary in the cell of the mesh phase separator (MPS) of the capillary means for ensuring the integrity of the fuel (CMEIF) with a long service life in chemically aggressive fuel components (FP): nitrogen tetroxide (NT) and asymmetric dimethylhydrazine (NDMH). The goal is to improve the selection of design parameters of the CMEIF through the refinement of traditional approaches to the calculation of the CHC MPS depending on the term of their operation. Task: to determine the rate of corrosion of the main structural material of the MPS - steel nets of the twill weave type, and its effect on the structural and geometric characteristics of the nets; to perform an experimental determination of the change in the MPS CHC; to improve the mathematical model for determining the MPS CHC, considering the term of their operation as part of the fuel system of space flight vehicles (SFV). The methods used are as follows: to determine the rate of corrosion - metallographic studies and measurement of the geometric dimensions of mesh samples; to determine the change in CHC - the bubble method. The following results were obtained. The coefficient of the maximum corrosion rate was determined. A new, refined dependence of the average value of Bo cr on the temperature of the FP was obtained. Linear regressions of changes in the approximated values of CHC MPS depending on the duration of their operation were obtained. An increase in the average arithmetic value of the wetting contact angle θ in the NDMG over 31 years of MPS operation was determined. An improved mathematical model for determining the CHC of MPS was obtained, considering the period of their operation in JSC and NDMH. Conclusions. The scientific novelty of the obtained results is as follows: for the first time, comprehensive studies were carried out to determine the rate of corrosion of the main structural material of MPS after a long period of their stay (from 14 to 31 years) in FP (NT and NDMG) and under their pairs, the results of which revealed regularities of flow corrosion processes in the liquid and gas phase, established corrosion rates and deduced coefficients, the application of which improves the engineering methods of calculating the main parameters of MPS; the physical model for calculating Bo kr received further development; the physical model for calculating the CHC has been improved, which makes it possible to calculate the value of the static CHC of the MPS with greater accuracy than it was before and to make the final design of the designed CMEIF more perfect and reliable.
Innovación y Liderazgo
Authors: Chavarria Randy 
Published: January 2024

Este artículo trata acerca de la innovación y el liderazgo, los cuales son dos aspectos fundamentales que impulsan el éxito y la competitividad de las organizaciones en el entorno empresarial actual. La innovación se refiere a la generación y aplicación de nuevas ideas, métodos, productos o servicios que aportan valor y marcan la diferencia en el mercado. Por su parte, el liderazgo se relaciona con la capacidad de influir, inspirar y guiar a los miembros de una organización hacia el logro de los objetivos comunes.
La relación entre la innovación y el liderazgo es bidireccional. Por un lado, la innovación requiere líderes que creen un entorno propicio para la generación de ideas y la experimentación. Por otro lado, el liderazgo efectivo se nutre de la innovación, ya que permite a las organizaciones adaptarse a los cambios, diferenciarse de la competencia y generar un valor sostenible.
PENERAPAN METODE CASE BASED REASONING PADA PEMILIHAN RESEP MAKANAN BERDASARKAN BAHAN
Authors: Chandra Wahyu 
Published: January 2024

Memasak adalah suatu kegiatan yang dilakukan oleh seseorang dengan mengolah bahan makanan melalui proses penerapan panas dengan tujuan tertentu. Dalam memasak, terdapat sedikit perbedaan pada jumlah takaran bahan dan bumbu serta cara pengolahannya sehingga diperlukan resep masakan untuk dijadikan acuan dalam memasak. Resep masakan adalah takaran yang digunakan untuk mengolah bahan makanan yang telah teruji keakuratannya. SMK Negeri 3 Bengkulu merupakan salah satu Sekolah Menengah Kejuruan yang ada di Kota Bengkulu. Pada jurusan tata boga siswa yang ingin memasak masih menggunakan buku resep (manual). Masalah utama dalam penelitian ini adalah bagaimana membantu siswa dalam mencari informasi seputar resep masakan sehingga diperlukannya suatu perangkat lunak yang dapat digunakan dalam pemilihan resep masakan menggunakan metode Case Based Reasoning dan aplikasi Web untuk mencari resep masakan yang sesuai dengan bahan makanan yang dimiliki oleh pengguna. Dari hasil pengujian yang dilakukan metode Case Based Reasoning dapat dijadikan solusi dalam penggunaan aplikasi untuk menentukan resep bahan makanan ini. Dalam penerapannya metode ini dapat memberikan persentase tingkat kesamaan penelusuran terhadap suatu resep masakan. Sehingga pengguna khususnya siswa siswi SMKN 3 Kota Bengkulu khususnya pada jurusan tata boga dapat menjadikan aplikasi ini sebagai salah satu solusi untuk memasak sebuah resep makanan dengan bahan yang ada. Berdasarkan pengujian sistem yang dilakukan, dapat disimpulkan bahwasanya aplikasi ini sudah sesuai dengan perancangan dan dapat memberikan kemudahan pengguna untuk melakukan penelusuran.
ANALISIS PENJADWALAN PROYEK PADA PEKERJAAN REPETITIF DENGAN METODE LINE OF BALANCE (LOB) DAN PRECEDENCE DIAGRAM METHOD (PDM)
Authors: Supriani Fepy 
Published: January 2024

Pekerjaan repetitif merupakan suatu kegiatan pekerjaan yang sama dan berulang dalam pembangunan proyek perumahan. Penjadwalan proyek yang tidak memperhitungkan suatu kegiatan pekerjaan yang berulang akan menyebabkan menyebabkan unit pekerjaan yang berulang tersebut mengalami penundaan. Metode penjadwalan yang tepat perlu diterapkan agar sumber daya proyek dapat dimanfaatkan secara efektif dan efisien. Penelitian ini bertujuan untuk menganalisis penjadwalan proyek dan mengetahui efektifitas penjadwalan untuk pekerjaan repetitif pada proyek pembangunan perumahan. Penelitian dilakukan menggunakan metode Line Of Balance (LOB) yang merupakan metode dengan menggunakan keseimbangan operasi untuk setiap pekerjaan dengan kinerja yang terus-menerus sehingga tidak adanya penundaan pekerjaan. Metode Precedence Diagram Method (PDM) menunjukan kegiatan kritis yamg tidak ditampilkan oleh metode LOB. Penelitian dilakukan untuk 10 unit rumah tipe 36/135 dengan jumlah pekerja 15 orang. Penelitian menghasilkan durasi pelaksanaan pembangunan 10 unit rumah tipe 36/135 adalah 69 hari. Perbandingan durasi penjadwalan existing proyek terdapat selisih waktu selama 9 hari dengan efektifitas pelaksanaan penjadwalan sebesar 0,115%.
Kata Kunci : Line Of Balance, Precedence Diagram Method, Proyek Repetitif, Penjadwalan.
PERANCANGAN TAMAN WISATA EDUKASI DENGAN PENDEKATAN ARSITEKTUR EKOLOGI DI KOTA BENGKULU
Authors: Sukma Saputri Sukma  , Dwi Oktavallyan Saputri  , Atik Prihatiningrum  
Published: January 2024

Kota Bengkulu memiliki berbagai obyek wisata baik wisata alam, budaya maupun buatan. Salah satu objek wisata yang cukup potensial untuk dikembangkan dan kurang mendapatkan sorotan yang lebih dari pihak pemerintah yakni wisata buatan. Masih sangat sedikit objek wisata buatan yang ada di Kota Bengkulu serta dilihat dari ketersediaan atraksi, amenitas dan aksesibilitas pariwisata yang kurang baik pada beberapa taman yang digunakan sebagai ruang terbuka hijau. Fungsi taman tidak hanya sebagai sebuah objek rekrasi namun dapat dikembangkan menjadi sebuah wisata yang dapat mengedukasi masyarakat. Penerapan arsitektur ekologi pada perancangan Taman Wisata Edukasi sebagai upaya menciptakan bangunan yang memperhatikan keseimbangan lingkungan sekaligus memberikan kesadaran dan pengetahuan kepada masyarakat tentang menjaga lingkungan. Dengan diterapkan prinsip-prinsip arsitektur ekologi pada pengolahan limbah dalam bangunan, tata massa bangunan, bentuk bangunan, dan penggunaan material. Sehingga Taman Wisata Edukasi dengan pedekatan arsitektur ekologi ini dapat menjadi wadah edukasi untuk semua kalangan dan dapat meminimalisir dampak kerusakan lingkungan.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF BIG BLUE BUTTON PADA MATAKULIAH STRUKTUR DATA
Authors: Cahyaningrum Yuniana , Adam Hendrawan  
Published: January 2024

Pengembangan media pembelajaran interaktif Big Blue Button pada matakuliah Struktur Data ini merupakan suatu langkah inovatif dalam dunia pendidikan. Adapun tujuan dari penelitian ini yaitu untuk meningkatkan efektivitas pembelajaran mahasiswa dalam memahami konsep-konsep dasar pada matakuliah Struktur Data. Penelitin ini berfokus pada perancangan dan pengembangan media pembelajaran berbasis Big Blue Button dengan berbagai fitur interaktif yang ada didalamnya. Tujuan utama dari penelitian ini untuk menciptakan lingkungan pembelajaran yang mendukung diskusi, interaktif, presentasi, dan kolaborasi antara dosen dan mahasiswa. Metode penelitian yang dipergunakan mencakup analisis kebutuhan, perancangan antarmuka, pengembangan, dan uji coba. Hasil dari penelitian ini menunjukkan bahwa penggunaan Big Blue Button pada matakuliah Struktur Data dapat meningkatkan kualitas pembelajaran, meningkatkan partisipasi mahasiswa, dan memudahkan akses ke materi pembelajaran. Selain itu, bagi institusi pendidikan dalam memanfaatkan teknologi web conferencing untuk memperkaya pengalaman pembelajaran mahasiswa. Harapannya penelitian ini berpotensi memberikan manfaat yang signifikan dalam pembelajaran jarak jauh terutama dalam konteks pembelajaran teknik pemrograman. Dengan menggunakan teknologi ini mahasiswa dapat memiliki pengalaman pembelajaran yang lebih interaktif dan kolaboratif dalam memahami konsep struktur data.
El trabajo en un mundo en transición hacia un Nuevo Orden Mundial
Authors: Ruesga Benito Santos Miguel 
Published: January 2024

Afirmar que se observan síntomas disruptivos en el actual modelo socioeconómico no significa que este esté acabado. Como señaló hace años Colin Crouch, la “extraña muerte del neoliberalismo”, sigue obstaculizando el surgimiento de un nuevo paradigma socioeconómico que refleja cambios sustanciales en el pensamiento humano.
Desde esta perspectiva, se plantea avanzar en un nuevo paradigma social, económico y político que ilumine caminos alternativos para la organización productiva y el modelo de consumo y nos permita mantener un equilibrio estable con el mundo natural en el que vivimos. Esto pone de relieve la necesidad de ir más allá de supuestos tradicionales desarrollando formas innovadoras de entender complejos desafíos, para superar el antropocentrismo que ha dominado el pensamiento occidental en los últimos siglos.
En este artículo se centran estas reflexiones, en una sociedad en transición, particularmente en el mundo del trabajo. Para, finalmente, introducir algunas prospecciones sobre lo que podría esperarse ante un cambio radical de paradigma socioeconómico, que contempla una paulatina desmercantilización del trabajo en respuesta a la emergencia planetaria que ya estamos viviendo.
Age influence on resistance and deformation of the human sutured meniscal horn in the immediate postoperative period
Authors: Peña-Trabalon Alejandro , Perez-Blanca Ana , Moreno-Vegas Salvador , Estebanez Campos M. Belen , Prado-Novoa Maria 
Published: January 2024

Introduction: To preserve knee function, surgical repair is indicated when a meniscal root disinsertion occurs. However, this surgery has not yet achieved complete recovery of the joint´s natural biomechanics, with the meniscus-suture interface identified as a potentially determining factor. Knowing the deformation and resistance behavior of the sutured meniscal horn and whether these properties are preserved as the patient ages could greatly contribute to improving repair outcomes.Methods: A cadaveric experimental study was conducted on human sutured menisci classified into three n = 22 age groups (young ≤55; 55 &lt; middle-aged ≤75; 75 &lt; old) were subjected to load-to-failure test by suture pulling. Meniscal thickness at the suture hole was measured and the applied traction force and tissue deformation in the suture area in the direction of traction were recorded during the test. The traction load that initiated the meniscal cut-out, Fc, maximum load borne by the meniscus, Fu, tissue stress at the cut-out initiation, Sc, and equivalent stiffness modulus at the suture area, ms, were calculated.Results: At the tissue level, the resistance in terms of Sc decrease with age (young: 47.2 MPa; middle-aged: 44.7 MPa; old: 33.8 MPa) being significantly different between the young and the old group (p = 0.015). Mean meniscal thickness increased with age (young: 2.50 mm; middle-aged: 2.92 mm; old: 3.38 mm; p = 0.001). Probably due to thickening, no differences in resistance were found at the specimen level, i.e., in Fc (overall mean 58.2 N) and Fu (overall mean 73.6 N). As for elasticity, ms was lower in the old group than in the young group (57.5 MPa vs. 113.6 MPa, p = 0.02) and the middle-aged one (57.5 MPa vs. 108.0 MPa, p = 0.04).Conclusion: Regarding the influence of age on the sutured meniscal horn tissue, in vitro experimentation revealed that meniscal horn specimens older than 75 years old had a more elastic tissue which was less resistant to cut-out than younger menisci at the suture hole area. However, a thickening of the meniscal horns with age, which was also found, leveled out the difference in the force that initiated the tear, as well as in the maximum force borne by the meniscus in the load-to-failure test.
Generation of induced pluripotent stem cells from Bornean orangutans
Authors: Li Chia-Jung , Chang Chia-Chun , Tsai Li-Kuang , Peng Min , Lyu Wei-Ni , Yu Jane-Fang , Tsai Mong-Hsun , Sung Li-Ying 
Published: January 2024

Introduction: Orangutans, classified under the Pongo genus, are an endangered non-human primate (NHP) species. Derivation of induced pluripotent stem cells (iPSCs) represents a promising avenue for conserving the genetic resources of these animals. Earlier studies focused on deriving orangutan iPSCs (o-iPSCs) from Sumatran orangutans (Pongo abelii). To date, no reports specifically target the other Critically Endangered species in the Pongo genus, the Bornean orangutans (Pongo pygmaeus).Methods: Using Sendai virus-mediated Yamanaka factor-based reprogramming of peripheral blood mononuclear cells to generate iPSCs (bo-iPSCs) from a female captive Bornean orangutan. In this study, we evaluate the colony morphology, pluripotent markers, X chromosome activation status, and transcriptomic profile of the bo-iPSCs to demonstrate the pluripotency of iPSCs from Bornean orangutans.Results: The bo-iPSCs were successfully derived from Bornean orangutans, using Sendai virus-mediated Yamanaka factor-based reprogramming of peripheral blood mononuclear cells. When a modified 4i/L/A (m4i/L/A) culture system was applied to activate the WNT signaling pathway in these bo-iPSCs, the derived cells (m-bo-iPSCs) manifested characteristics akin to human naive pluripotent stem cells, including high expression levels of KLF17, DNMT3L, and DPPA3/5, as well as the X chromosome reactivation. Comparative RNA-seq analysis positioned the m-bo-iPSCs between human naive and formative pluripotent states. Furthermore, the m-bo-iPSCs express differentiation capacity into all three germlines, evidenced by controlled in vitro embryoid body formation assay.Discussion: Our work establishes a novel approach to preserve the genetic diversity of endangered Bornean orangutans while offering insights into primate stem cell pluripotency. In the future, derivation of the primordial germ cell-like cells (PGCLCs) from m-bo-iPSCs is needed to demonstrate the further specific application in species preservation and broaden the knowledge of primordial germ cell specification across species.
Identification of hub genes in heart failure by integrated bioinformatics analysis and machine learning
Authors: Wang Tengfei , Sun Yongyou , Zhao Yingpeng , Huang Jinhe , Huang Ying 
Published: January 2024

ObjectiveTo screen feature genes of heart failure patients through machine learning methods, in order to identify characteristic genes driving heart failure and investigate the progression of heart failureMethodsHeart failure patient samples were downloaded from the public database GEO (Gene Expression Omnibus), including the datasets GSE116250, GSE120895, and GSE59867. GSE116250 and GSE120895 were used as the testing set, while GSE59867 was used as the validation set. LASSO regression analysis and SVM-RFE were utilized to identify feature genes.ResultsAnalysis showed that among the differentially expressed genes between normal and heart failure patients, 9 genes were upregulated and 10 genes were downregulated. ROC curve analysis in the training set showed that TAGLN and SGPP2 had AUC values greater than 0.7. Moreover, SDSL and SMTNL2 had even higher AUC values of greater than 0.9. However, further analysis in the validation set showed that only SDSL had an AUC value greater than 0.7. Western blot experiments, RT-PCR, and ISO-induced experiments confirmed that SDSL was highly expressed in heart failure patients and promoted heart failure progression. In addition, SDSL promoted PARP1 expression and knockdown of SDSL expression led to decreased Cleaved-PARP1 expression and reduced cardiomyocyte apoptosis. Conversely, overexpression of SDSL resulted in increased PARP1 expression and myocardial cell apoptosis. These results suggest that elevated expression of SDSL in cardiomyocytes from heart failure patients may be an important factor promoting the occurrence and development of heart failure.ConclusionsUsing machine learning methods and experimental validation, it has been demonstrated that SDSL is a driving gene in patients with heart failure, providing a new treatment direction for clinical treatment.
Adaptive linear inversion of Moho topography in the Tibetan Plateau by combining gravity and seismic data
Authors: Yu Hangtao , Chen Haopeng , Xu Chuang , Li Jinbo , Chai Yi , Jian Guangyu , Zhang Hui , Xu Ming , Zhao Qiang , Tu Jun 
Published: January 2024

The Tibetan Plateau is a region where the Indian and Asian-European plates collide. A high-precision Moho topography model is important for the study of plate motion and internal tectonics of the Tibetan Plateau. However, previous gravity-based models failed in representing adequately the Moho topography because crustal effects and biases in the inversion parameters were not fully considered. To address these issues, we extracted the gravity effect caused by the crust using wavelet multi-scale analysis, and used an adaptive linear inversion method with available gravity and seismic data to estimate more accurate inversion parameters. With these two improvements, we inverted for a high-precision Moho topography model of the Tibetan Plateau. The results show that the majority of the Tibetan Plateau has a Moho depth of 60–70 km. The Moho depth in the center of the Qaidam Basin is about 50 km, and the Moho topography between the east and west of the basin has obvious undulations. The Moho depth of the Tarim Basin ranges from 38–50 km. While the undulation of Moho is limited in the center of the basin, obvious uplifts are shown in northern and southern basin. The plate driving force between the Tibetan Plateau and the Tarim Basin may be the primary cause of this phenomenon. By comparing the difference with the seismic data, we found that the RMS of our model is 2.8 km smaller than that of the CRUST 1.0 model, which shows that our model is more accurate.