bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Placebo-Controlled Study of Low-Dose Warfarin for the Prevention of Central Venous Catheter–Associated Thrombosis in Patients With Cancer
Authors: Couban Stephen , Goodyear Michael , Burnell Margot , Dolan Sean , Wasi Parveen , Barnes David , MacLeod Darlene , Burton Erica , Andreou Pantelis , Anderson David R. 
Published: March 2005

Purpose In this multicenter, randomized, placebo-controlled clinical trial, we studied whether warfarin 1 mg daily reduces the incidence of symptomatic central venous catheter (CVC) –associated thrombosis in patients with cancer. Patients and Methods Two hundred fifty-five patients with cancer who required a CVC for at least 7 days were randomly assigned to receive warfarin 1 mg or placebo. Results There were 11 (4.3%) symptomatic CVC-associated thromboses among 255 patients, with no difference in the incidence of symptomatic CVC-associated thrombosis between patients taking warfarin 1 mg daily (six of 130 patients; 4.6%) and patients taking placebo (five of 125 patients; 4.0%; hazard ratio, 1.20; 95% CI, 0.37 to 3.94). Warfarin had no effect on CVC life span (84 days v 63 days in control and warfarin groups, respectively; 95% confidence limit, −16 to 55 days; P = .09), and it did not affect the number of premature CVC removals (23.2% v 25.4% in control and warfarin groups, respectively; 95% confidence limit of difference −8.34 to 12.71; P = .68) or the frequency of major bleeding episodes (2% v 0% in control and warfarin groups, respectively; P = .5, Fisher's exact test). Conclusion Symptomatic CVC-associated thrombosis in patients with cancer, although significant, is less common than previously reported. In this study, the administration of warfarin 1 mg daily did not reduce the incidence of symptomatic CVC-associated thrombosis in patients with cancer. However, the low rate of symptomatic CVC-associated thrombosis means that a much larger trial is required to address this issue definitively.
Chemoimmunotherapy With Fludarabine, Cyclophosphamide, and Rituximab for Relapsed and Refractory Chronic Lymphocytic Leukemia
Authors: Wierda William , O’Brien Susan , Wen Sijin , Faderl Stefan , Garcia-Manero Guillermo , Thomas Deborah , Do Kim-Anh , Cortes Jorge , Koller Charles , Beran Miloslav , Ferrajoli Alessandra , Giles Francis , Lerner Susan , Albitar Maher , Kantarjian Hagop , Keating Michael 
Published: March 2005

Purpose The efficacy, toxicity, and tolerability of chemoimmunotherapy with the combination of fludarabine, cyclophosphamide, and rituximab (FCR) were evaluated in previously treated patients with chronic lymphocytic leukemia (CLL). The purpose of this study was to improve the complete remission (CR) rate for previously treated patients and evaluate the quality of bone marrow response. Patients and Methods One hundred seventy-seven previously treated patients with CLL were evaluated. Treatment consisted of rituximab 375 mg/m2 day 1 of course 1 and 500 mg/m2 day 1 of courses 2 to 6; fludarabine 25 mg/m2/d days 2 to 4 of course 1 and days 1 to 3 of courses 2 to 6; and cyclophosphamide 250 mg/m2/d days 2 to 4 of course 1 and days 1 to 3 of courses 2 to 6. Courses were repeated every 4 weeks. Results CR was achieved in 25% of 177 patients, and nodular partial remission and partial remission were achieved in 16% and 32% of patients, respectively; the overall response rate was 73%. Twelve (32%) of 37 complete responders tested achieved molecular remission in bone marrow. Univariate and multivariate analyses were used to identify pretreatment patient characteristics associated with CR and overall remission, longer time to progression, and overall survival. Conclusion The FCR regimen was an active and well-tolerated treatment for previously treated patients with CLL. Myelosuppression was the most common toxicity. FCR induced the highest CR rate reported in a clinical trial of previously treated patients with CLL. Furthermore, molecular remissions were achieved in a third of patients achieving CR.
Aerobiology in the operating room and its implications for working standards
Authors: Friberg B , Friberg S 
Published: March 2005

Two novel operating room (OR) ventilation concepts, i.e. the upward displacement or thermal convection system and the exponential ultra-clean laminar air flow (LAF) designed to function without extra walls, were evaluated from a bacteriological point of view. The thermal convection system (17 air changes/h) was compared with conventional ventilation (16 air changes/h) with an air inlet at the ceiling and evacuation at floor level. The exponential LAF was compared with the vertical ultra-clean LAF and the horizontal ultra-clean LAF, both with extra side walls. The comparison was made using strictly standardized simulated operations and, except for the horizontal LAF, it was performed in the same OR where the type of ventilation was changed. In the different areas important for surgical asepsis, the thermal system resulted in a twofold to threefold increase in bacterial air and surface counts compared to the conventional system (statistical significance = p < 0.05-0.0001). The bacteriological efficiency of the exponential LAF was equal to the horizontal and vertical LAF units with extra walls in the OR, and all three systems easily fulfilled the criteria for ultra-clean air, i.e. bacteria-carrying particles <10/m3. In the areas important for surgical asepsis the turbulent ventilation systems yielded highly significant correlation between air and surface contamination (p < 0.02-0.0006). No such correlation existed in the LAF systems.
Alternative Methods for Measuring Energy Content in Winter Flounder
Authors: Plante Sébastien , Audet Céline , Lambert Yvan , Noüe Joël 
Published: March 2005

Abstract
Indices of energy reserves may represent interesting parameters that can be used as bioindicators in environmental studies. The goal of this study was to identify a water–energy model that could predict energy reserves in winter flounder Pseudopleuronectes americanus. Winter flounder kept in captivity and fed different food types (either capelin Mallotus villosus or Atlantic herring Clupea harengus, amphipods Anonyx sarsi, and wet pellets) for 2, 5, and 14 months and wild fish captured in May, July, and October were used to show a large range in energy content. High levels of correlation were observed between water and energy contents in fish carcasses (r2 = 0.82) and muscle (r2 = 0.75). However, the biochemical composition of the liver remained relatively constant, despite changes in the hepatosomatic index. The condition factor (somatic weight/length3) was associated with energy reserves (i.e., water contents), but the coefficients of determination were smaller (0.18 &lt; r2 &lt; 0.34). We found that muscle water content, which can easily be determined, is an efficient way to accurately predict energy reserves in winter flounder.
Centrarchid Assemblages in Mississippi State-Operated Fishing Lakes
Authors: Olive J. A. , Miranda L. E. , Hubbard W. D. 
Published: March 2005

Abstract
We evaluated electrofishing catch per effort in 27 state-operated fishing lakes in Mississippi to identify patterns of centrarchid community composition and to determine whether those patterns were related to selected environmental characteristics and to artificial nutrient enrichment. Ordination with detrended correspondence analysis recognized two major axes accounting for 77% of the variability in species ordination. Axis 1 showed a distinct separation between the body sizes of various species. A notable exception was the density of small (&lt;30 cm) largemouth bass Micropterus salmoides, which aligned with the large individuals of other centrarchid species. This pattern suggested that through predation, high densities of small largemouth bass exerted significant control over the size structure of fish communities. Axis 2 separated species of crappies Pomoxis spp., suggesting that conditions other than strong species interactions also moderated the composition of crappies in the assemblages. However, neither lake morphometry nor watershed composition exhibited a major influence over axes 1 or 2. In small, intensively managed lakes with low habitat complexity, the regulatory importance of biotic interactions may overwhelm that of abiotic factors. Nutrient enrichment influenced community structure by changing the densities of bluegill Lepomis macrochirus and largemouth bass substantially but had a minor or no effect on other species. The management techniques used in these state-operated lakes are usually targeted toward a particular species without adequately considering the other species within the community. Our results show that attention to community-level interactions could provide valuable insight into factors that affect the quality of the fishery, insight that is not available through traditional population-level assessments.
Revisiting the 23 February 1892 Laguna Salada Earthquake
Authors: Hough Susan E. , Elliott Austin 
Published: March 2005

Abstract
According to some compilations, the Laguna Salada, Baja California, earthquake of 23 February 1892 ranks among the largest earthquakes in California and Baja California in historic times. Although surface rupture was not documented at the time of the earthquake, recent geologic investigations have identified and mapped a rupture on the Laguna Salada fault that can be associated with high probability with the 1892 event (Mueller and Rockwell, 1995). The only intensity-based magnitude estimate for the earthquake, M 7.8, was made by Strand (1980) based on an interpretation of macroseismic effects and a comparison of isoseismal areas with those from instrumentally recorded earthquakes. In this study we reinterpret original accounts of the Laguna Salada earthquake. We assign modified Mercalli intensity (MMI) values in keeping with current practice, focusing on objective descriptions of damage rather than subjective human response and not assigning MMI values to effects that are now known to be poor indicators of shaking level, such as liquefaction and rockfalls. The reinterpreted isoseismal contours and the estimated magnitude are both significantly smaller than those obtained earlier. Using the method of Bakun and Wentworth (1997) we obtain a magnitude estimate of M 7.2 and an optimal epicenter less than 15 km from the center of the mapped Laguna Salada rupture. The isoseismal contours are elongated toward the northwest, which is qualitatively consistent with a directivity effect, assuming that the fault ruptured from southeast to northwest. We suggest that the elongation may also thus reflect wave propagation effects, with more efficient propagation of crustal surface (Lg) waves in the direction of the overall regional tectonic fabric.
The tachocline and the solar dynamo
Authors: Gilman P. A. 
Published: March 2005

AbstractThe solar tachocline contains a rich variety of physics, and contributes in many ways to the workings of the solar dynamo. It includes complex quasi‐equilibrium states supported by the near balances of gas and magnetic pressure gradients, gravity, magnetic curvature stresses, Coriolis and other forces. The dynamics include overshooting convection, waves of several types, hydrodynamic and MHD instabilities on several spatial and temporal scales, several types of boundary layers and dynamo action. The dynamo processes present include the in situ generation of poloidal fields by global MHD and/or magnetic buoyancy instabilities; the advection of these poloidal fields by meridional circulation; the generation of toroidal fields from shearing by the differential rotation; and storage of these fields and their subsequent eruption into the convection zone. The tachocline probably also plays a significant role in creating magnetic patterns that are seen in the photosphere. This talk will of necessity focus on a subset of these topics, including particularly global MHD instabilities and whether we can see evidence of them in surface magnetic data, meridional circulation and the boundary layers that limit it, possible jets in the tachocline, and certain solar dynamo questions. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Topology and dynamics of abnormal granulation
Authors: Nesis A. , Hammer R. , Schleicher H. 
Published: March 2005

AbstractWe present a 2D spectroscopic time series of an abnormal granulation region and describe the formation and decay of structures, in particular the gradual restitution of a granulation‐like pattern. This behavior is discussed in relation to magnetoconvection. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Complex 1H,13C‐NMR relaxation and computer simulation study of side‐chain dynamics in solid polylysine
Authors: Krushelnitsky Alexey , Reichert Detlef 
Published: March 2005

AbstractThe side‐chain dynamics of solid polylysine at various hydration levels was studied by means of proton spin–lattice relaxation times measurements in the laboratory and tilted (off‐resonance) rotating frames at several temperatures as well as Monte Carlo computer simulations. These data were analyzed together with recently measured carbon relaxation data (A. Krushelnitsky, D. Faizullin, and D. Reichert, Biopolymers, 2004, Vol. 73, pp. 1–15). The analysis of the whole set of data performed within the frame of the model‐free approach led us to a conclusion about three types of the side‐chain motion. The first motion consists of low amplitude rotations of dihedral angles of polylysine side chains on the nanosecond timescale. The second motion is cis–trans conformational transitions of the side chains with correlation times in the microsecond range for dry polylysine. The third motion is a diffusion of dilating defects described in (W. Nusser, R. Kimmich, and F. Winter, Journal of Physical Chemistry, 1988, Vol. 92, pp. 6808–6814). This diffusion causes almost no reorientation of chemical bonds but leads to a sliding motion of side chains with respect to each other in the nanosecond timescale. This work evidently demonstrates the advantages of the simultaneous quantitative analysis of data obtained from different experiments within the frame of the same mathematical formalism, providing for the detailed description of the nature and geometry of the internal molecular dynamics. © 2005 Wiley Periodicals, Inc. Biopolymers 78: 129–139, 2005This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
The Zirconium Alkoxide‐Catalyzed Aldol‐Tishchenko Reaction of Ketone Aldols
Authors: Schneider Christoph , Hansch Markus , Weide Timo 
Published: March 2005

AbstractThe aldol‐Tishchenko reaction of ketone aldols as enol equivalents has been developed as an efficient strategy to furnish differentiated 1,3‐anti‐diol monoesters in one step. The thermodynamically unstable ketone aldols undergo a facile retro‐aldolization to yield a presumed zirconium enolate in situ, which then undergoes the aldol‐Tishchenko reaction in typically high yields and with complete 1,3‐anti diastereocontrol. Evaluation of a broad range of metal alkoxides as catalysts and optimization of the reaction protocol led to a modified zirconium alkoxide catalyst with attenuated Lewis acidity and dichloromethane as solvent, which resulted in suppression of the undesired acyl migration to a large extent. Various ketone aldols have been prepared and subjected to the general process, giving rise to a broad range of differently substituted 1,3‐anti‐diol monoesters, which may be hydrolyzed to the corresponding 1,3‐anti‐diols.
Magnetostructural Studies on Ferromagnetically Coupled Copper(II) Cubanes of Schiff‐Base Ligands
Authors: Mukherjee Arindam , Raghunathan Rajamani , Saha Manas K. , Nethaji Munirathinam , Ramasesha Suryanarayanasastry , Chakravarty Akhil R. 
Published: March 2005

AbstractThree cubane copper(II) clusters, namely [Cu4(HL′)4] (1), [Cu4L2(OH)2] (2), and [Cu4L2(OMe)2] (3), of two pentadentate Schiff‐base ligands N,N′‐(2‐hydroxypropane‐1,3‐diyl)bis(acetylacetoneimine) (H3L′) and N,N′‐(2‐hydroxypropane‐1,3‐diyl)bis(salicylaldimine) (H3L), are prepared, structurally characterized by X‐ray crystallography, and their variable‐temperature magnetic properties studied. Complex 1 has a metal‐to‐ligand stoichiometry of 1:1 and it crystallizes in the cubic space group P$\bar 4$3n with a structure that consists of a tetranuclear core with metal centers linked by a μ3‐alkoxo oxygen atom to form a cubic arrangement of the metal and oxygen atoms. Each ligand displays a tridentate binding mode which means that a total of eight pendant binding sites remain per cubane molecule. Complexes [Cu4L2(OH)2] (2) and [Cu4L2(OMe)2] (3) crystallize in the orthorhombic space group Pccn and have a cubane structure that is formed by the self‐assembly of two {Cu2L}+ units. The variable‐temperature magnetic susceptibility data in the range 300–18 K show ferromagnetic exchange interactions in the complexes. Along with the ferromagnetic exchange pathway, there is also a weak antiferromagnetic exchange between the copper centers. The theoretical fitting of the magnetic data gives the following parameters: J1=38.5 and J2=−18 cm−1 for 1 with a triplet (S=1) ground state and quintet (S=2) lowest excited state; J1=14.7 and J2=−18.4 cm−1 for 2 with a triplet ground state and singlet (S=0) lowest excited state; and J1=33.3 and J2=−15.6 cm−1 for 3 with a triplet ground state and quintet lowest excited state, where J1 and J2 are two different exchange pathways in the cubane {Cu4O4} core. The crystal structures of 2⋅6 H2O and 3⋅2 H2O⋅THF show the presence of channels containing the lattice solvent molecules.
A Mesoporous Template Route to the Low‐Temperature Preparation of Efficient Green Light Emitting Zn2SiO4:Mn Phosphors.
Authors: Xiong Liangming , Shi Jianlin , Gu Jinlou , Li Liang , Huang Weimin , Gao Jianhua , Ruan Meiling 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Preparation of Enantiopure Butane‐2,3‐diacetals of Glycolic Acid and Alkylation Reactions Leading to α‐Hydroxyacid and Amide Derivatives.
Authors: Ley Steven V. , Diez Elena , Dixon Darren J. , Guy Richard T. , Michel Patrick , Nattrass Gillian L. , Sheppard Tom D. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of (+)‐(1S,4R)‐1‐(1‐Chlorovinyl)‐7,7‐dimethylbicyclo[2.2.1]heptan‐2‐one.
Authors: Vostrikov N. S. , Vasikov V. Z. , Spirikhin L. V. , Miftakhov M. S. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Bismuth(III) Trifluoromethanesulfonate and Trifluoroacetate as Convenient and Efficient Catalysts for Regio‐ and Chemoselective Ring Opening of Epoxides in Reactions with Anilines.
Authors: Khosropour A. R. , Khodaei M. M. , Ghozati K. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Five‐Membered 2,3‐Dioxo Heterocycles. Part 48. Reaction of 3‐Aroyl‐ and 3‐Heteroyl‐2,4‐dihydro‐1H‐pyrrolo[2,1‐c][1,4]benzoxazine‐1,2,4‐triones with 3‐Amino‐5,5‐dimethyl‐2‐cyclohexenone.
Authors: Mashevskaya I. V. , Duvalov A. V. , Tolmacheva I. A. , Aliev Z. G. , Maslivets A. N. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Evaluation of Chiral Bidentate Ligand—Metal Complexes in Asymmetric 1,3‐Dipolar Cycloaddition Reaction of Nitrones with 3‐Alkenoyl‐2‐oxazolidinones.
Authors: Saito Takao , Yamada Takuya , Miyazaki Shingo , Otani Takashi 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Isosteric N‐Arylpiperazine Replacements in a Series of Dihydropyridine NPY1 Receptor Antagonists.
Authors: Luo Guanglin , Mattson Gail K. , Bruce Marc A. , Wong Henry , Murphy Brian J. , Longhi Daniel , Antal‐Zimanyi Ildiko , Poindexter Graham S. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Syntheses of 2,4,6‐Trisubstituted Pyrimidine Derivatives as a New Class of Antifilarial Topoisomerase II Inhibitors.
Authors: Katiyar Sanjay Babu , Bansal Iti , Saxena J. K. , Chauhan P. M. S. 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
α‐1‐C‐Alkyl‐1‐deoxynojirimycin Derivatives as Potent and Selective Inhibitors of Intestinal Isomaltase: Remarkable Effect of the Alkyl Chain Length on Glycosidase Inhibitory Profile.
Authors: Godin Guillaume , Compain Philippe , Martin Olivier R. , Ikeda Kyoko , Yu Liang , Asano Naoki 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Anticonvulsant Activity of New 2‐Substituted‐5‐[2‐(2‐fluorophenoxy)phenyl]‐1,3,4‐oxadiazoles and 1,2,4‐Triazoles.
Authors: Almasirad Ali , Tabatabai Sayyed A. , Faizi Mehrdad , Kebriaeezadeh Abbas , Mehrabi Nazila , Dalvandi Afshin , Shafiee Abbas 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Tryptamine‐Based Human β3‐Adrenergic Receptor Agonists. Part 2. SAR of the Methylene Derivatives.
Authors: Sawa Masaaki , Tateishi Hirotaka , Mizuno Kazuhiro , Harada Hiroshi , Oue Mayumi , Tsujiuchi Hiroshi , Furutani Yasuji , Kato Shiro 
Published: March 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Usefulness of the nurse‐assisted screening and psychiatric referral program
Authors: Shimizu Ken , Akechi Tatsuo , Okamura Masako , Oba Akira , Fujimori Maiko , Akizuki Nobuya , Uchitomi Yosuke 
Published: March 2005

AbstractBACKGROUNDMajor depression and adjustment disorders are common psychiatric disorders in patients with cancer, but they are often overlooked in clinical oncology settings. The nurse‐assisted screening and psychiatric referral program (NASPRP) has been introduced in clinical practice to facilitate psychiatric treatment for major depression and adjustment disorders. This study assessed the usefulness of the NASPRP and compared it with usual practice.METHODSThe program consists of two stages. In the first stage, consecutive patients newly admitted to the Oncology/Hematology Unit are administered the Distress and Impact Thermometer (DIT) by nurses as a brief screening tool for major depression and adjustment disorders. In the second stage, the nurses recommend psychiatric referral to patients with scores above the cutoff point. Patients' records were reviewed for a 3‐month period before the start of the program and during the 3‐month period after the start of the program. These records were then compared.RESULTSOf 157 patients newly admitted during the program period, 86.0% (135/157) completed the DIT and results were positive in 49.6% (67/135), but only 28.2% (19/67) accepted psychiatric referral. Ultimately, 11.5% (18/157) of patients newly admitted were diagnosed with major depression or adjustment disorders and treated by psychiatric service, a significantly higher proportion than during the preceding 3‐month period, before the program was begun (2.5%; P = 0.001).CONCLUSIONThe NASPRP enabled identification of major depression and adjustment disorders in patients with cancer and introduced them to psychiatric treatment. Nevertheless, there is room for improvement in the program. Cancer 2005. © 2005 American Cancer Society.