bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic HIV‐1 Tat action induces HLA‐DR downregulation in B cells: A mechanism for lymphoma immune escape in people living with HIV
Authors: Shmakova Anna , Hugot Coline , Kozhevnikova Yana , Schwager (Karpukhina) Anna , Tsimailo Ivan , Gérard Laurence , Boutboul David , Oksenhendler Eric , Szewczyk‐Roszczenko Olga , Roszczenko Piotr , Buzun Kamila , Sheval Eugene V. , Germini Diego , Vassetzky Yegor 
Published: January 2024

AbstractDespite the success of combination antiretroviral therapy, people living with human immunodeficiency virus (HIV) still have an increased risk of Epstein−Barr virus (EBV)‐associated B cell malignancies. In the HIV setting, B cell physiology is altered by coexistence with HIV‐infected cells and the chronic action of secreted viral proteins, for example, HIV‐1 Tat that, once released, efficiently penetrates noninfected cells. We modeled the chronic action of HIV‐1 Tat on B cells by ectopically expressing Tat or TatC22G mutant in two lymphoblastoid B cell lines. The RNA‐sequencing analysis revealed that Tat deregulated the expression of hundreds of genes in B cells, including the downregulation of a subset of major histocompatibility complex (MHC) class II‐related genes. Tat‐induced downregulation of HLA‐DRB1 and HLA‐DRB5 genes led to a decrease in HLA‐DR surface expression; this effect was reproduced by coculturing B cells with Tat‐expressing T cells. Chronic Tat presence decreased the NF‐ᴋB pathway activity in B cells; this downregulated NF‐ᴋB‐dependent transcriptional targets, including MHC class II genes. Notably, HLA‐DRB1 and surface HLA‐DR expression was also decreased in B cells from people with HIV. Tat‐induced HLA‐DR downregulation in B cells impaired EBV‐specific CD4+ T cell response, which contributed to the escape from immune surveillance and could eventually promote B cell lymphomagenesis in people with HIV.
RNA recognition by PKR during DNA virus infection
Authors: Zhang Ruilin , Karijolich John 
Published: January 2024

AbstractProtein kinase R (PKR) is a double‐stranded RNA (dsRNA) binding protein that plays a crucial role in innate immunity during viral infection and can restrict both DNA and RNA viruses. The potency of its antiviral function is further reflected by the large number of viral‐encoded PKR antagonists. However, much about the regulation of dsRNA accumulation and PKR activation during viral infection remains unknown. Since DNA viruses do not have an RNA genome or RNA replication intermediates like RNA viruses do, PKR‐mediated dsRNA detection in the context of DNA virus infection is particularly intriguing. Here, we review the current state of knowledge regarding the regulation of PKR activation and its antagonism during infection with DNA viruses.
Association between preablation and postablation neutrophil‐lymphocyte ratio and atrial fibrillation recurrence: A meta‐analysis
Authors: Lekkala Sai Prasanna , Mellacheruvu Sai Priyanka , Gill Karanvir Singh , Khela Puneeteshwar Singh , Singh Gurjot , Jitta Sahas Reddy , Patel Manali , Hingora Mohmed Junaid , Desai Rupak 
Published: January 2024

AbstractAtrial fibrillation (AF) recurrence has become common in patients who have undergone catheter ablation. High neutrophil lymphocyte ratios (NLR) have been linked to an increased risk of recurrent AF. The research is, however, not conclusive. This meta‐analysis addressed the value of easily accessible and affordable pre‐ and postablation NLR levels as indicators of AF recurrence in patients who had undergone ablation. We searched PubMed, SCOPUS, and Google Scholar for pertinent studies through May 2023. Using random effects models, the aggregated odds ratio (OR) of pre‐ and post‐NLR and AF recurrence was estimated. Inter‐study heterogeneity was described using I2 statistics and leave‐one‐out sensitivity analysis. A p‐value < .05 was considered statistically significant. The literature search yielded 270 studies, seven of which were included in this meta‐analysis of 1923 patients who experienced AF recurrence after undergoing ablation. There are five retrospective and two prospective studies with a mean follow‐up of 20.5 months. The unadjusted odds ratio (OR) of AF recurrence for preablation NLR was 1.33 (95% CI: 1.04–1.71, p < .01, I2 = 95.49%), while the adjusted OR was 1.45 (95% CI: 0.87–2.43, p < .01, I2 = 95.1%). The unadjusted odds ratio (OR) for postablation NLR was 1.21 (95% CI: 1.09–1.36, p < .01, I2 = 85.9%), and the adjusted odds ratio (OR) was 1.28 (95% CI: 0.93–1.76), demonstrating significant heterogeneity (I2 = 95.32%) with a p‐value < .01. NLR was significantly associated with AF recurrence prediction. To detect AF recurrence, we recommend that clinicians add a simple NLR blood test to their diagnostic modalities.
Outcomes of left bundle branch area pacing compared to His bundle pacing and right ventricular apical pacing in Japanese patients with bradycardia
Authors: Kono Hiroyuki , Kuramitsu Shoichi , Fukunaga Masato , Korai Kengo , Nagashima Michio , Hiroshima Kenichi , Ando Kenji 
Published: January 2024

AbstractBackgroundHis bundle pacing (HBP) and left bundle branch area pacing (LBBAP) emerge as better alternatives to right ventricular apical pacing (RVAP) in patients with bradycardia requiring permanent cardiac pacing. We aimed to compare the clinical outcomes of LBBAP, HBP, and RVAP in Japanese patients with bradycardia.MethodsA total of 424 patients who underwent successful pacemaker implantation (HBP, n = 53; LBBAP, n = 75; and RVAP, n = 296) were retrospectively enrolled in this study. The primary study endpoint was the cumulative incidence of heart failure hospitalization (HFH) during the follow‐up.ResultsThe success rate for implantation was higher in the LBBAP group than in the HBP group (94.9% and 81.5%, respectively). Capture threshold increase >1V during the follow‐up occurred in the HBP and RVAP groups (9.4% and 5.1%, respectively), while it did not in the LBBAP group. The cumulative incidence of HFH was significantly lower in the LBBAP group than the RVAP (adjusted hazard ratio, 0.12 [95% confidence interval: 0.02–0.86]; p = .034); it did not differ between the HBP and RVAP groups (adjusted hazard ratio, 0.48 [95% confidence interval: 0.17–1.34]; p = .16). Advanced age, mean percent right ventricular pacing (per 10% increase), left ventricular ejection fraction <50%, and RVAP were associated with HFH.ConclusionsCompared to RVAP and HBP, LBBAP appeared more feasible and effective in patients with bradycardia requiring permanent cardiac pacing.
Model‐based reconstruction for looping‐star MRI
Authors: Xiang Haowei , Fessler Jeffrey A. , Noll Douglas C. 
Published: January 2024

AbstractPurposeThe aim of this study was to develop a reconstruction method that more fully models the signals and reconstructs gradient echo (GRE) images without sacrificing the signal to noise ratio and spatial resolution, compared to conventional gridding and model‐based image reconstruction method.MethodsBy modeling the trajectories for every spoke and simplifying the scenario to only echo‐in and echo‐out mixture, the approach explicitly models the overlapping echoes. After modeling the overlapping echoes with two system matrices, we use the conjugate gradient algorithm (CG‐SENSE) with the nonuniform FFT (NUFFT) to optimize the image reconstruction cost function.ResultsThe proposed method is demonstrated in phantoms and in‐vivo volunteer experiments for three‐dimensional, high‐resolution T2*‐weighted imaging and functional MRI tasks. Compared to the gridding method, the high resolution protocol exhibits improved spatial resolution and reduced signal loss as a result of less intra‐voxel dephasing. The fMRI task shows that the proposed model‐based method produced images with reduced artifacts and blurring as well as more stable and prominent time courses.ConclusionThe proposed model‐based reconstruction results shows improved spatial resolution and reduced artifacts. The fMRI task shows improved time series and activation map due to the reduced overlapping echoes and under‐sampling artifacts.
The role of patient treatment specific expectations on the outcomes of musculoskeletal physical therapy treatment: A scoping review
Authors: Wassinger Craig A. , Bourassa Michael , Rheault Ian , Carroll Anthony , Waldecker Christa , Weyant‐Blevins Emily , Sole Gisela , Wright Alexis A. 
Published: January 2024

AbstractBackgroundIt is unknown how well patient treatment expectations are related to outcomes within musculoskeletal physical therapy. The purpose of this scoping review was to examine the association between patient treatment expectations and outcomes following physical therapy care for musculoskeletal injury and to identify gaps in the literature on this topic.Data SourcesPubMed, CINAHL Complete, PEDro, SPORTDiscus, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and PsycINFO were searched from January 2005. Concepts represented in the search included physical therapy, patient expectations, and patient outcomes, as well as their relevant synonyms.Data Extraction and SummaryA custom spreadsheet was used to chart demographic details, study design, and key findings from eligible studies. The critical appraisal skills programme (CASP) for cohort studies was used to determine reporting comprehensiveness and fit for inclusion into the review.ResultsTwelve (12) studies were included in this review representing 1855 patients across a variety of patients with musculoskeletal disorders. Studies were most commonly secondary analyses of controlled trials (n = 10) or controlled trials (n = 2) and yielded high CASP scores. A wide range of methods were used to determine patient expectations. The impact of patient treatment expectations was mixed, with some studies indicating a positive relationship between expectation fulfilment and improved outcomes, while others indicate no such relationship.ConclusionThe relationship between treatment expectations and outcomes within musculoskeletal physical therapy practice is not clear. Future studies with planned comparisons are needed to define appropriate methods to seek patient expectations and measure outcome differences between groups based on expectation fulfilment.
Preparation and physical properties of CeO2 doped and modified epoxy resin composites
Authors: Liang Dayu , Yang Jundong , Li Xiang , Wang Wenzhi , Qi Jianlei , Lu Zhimin 
Published: January 2024

AbstractEpoxy resin is a widely used polymer material, while its low mechanical properties and thermal stability limit its use in extreme environments such as high temperature and high pressure. In order to improve the performance of EP, this study assessed the enhancement of mechanical properties and thermal stability of EP by stearic acid‐modified n‐CeO2 and its mechanism. Laser particle size analyzers, transmission electron microscopes, and other instruments were used to characterize n‐CeO2. Universal testing machines, thermogravimetric analyzers, and other instruments were used to test n‐CeO2/EP nanocomposites. The results show that fatty acids effectively coated the surface of n‐CeO2, reducing its central particle size from 0.248 μm to 0.193 μm and improving its dispersion and compatibility. The tensile, flexural, impact strength, maximum decomposition temperature, and glass transition temperature (Tg) increased by 382%, 554%, 698%, 5%, and 10%, respectively with 2 wt% filler content. The scanning electron microscopy (SEM) images showed that the addition of n‐CeO2 induced plastic deformation and crack formation in the EP matrix, which enhanced the toughness of the composite material. This study provided the effective methods and basis for the preparation of high‐performance n‐CeO2/EP nanocomposites.Highlights
Nano cerium dioxide was modified to improve its dispersion by using stearic acid.
High‐performance nanocomposites were prepared by using modified nanoparticles.
The stiffness and toughness of the epoxy resin were enhanced by adding n‐CeO2.
Thermal stability and heat resistance of the epoxy resin were improved by doping n‐CeO2.
SEM images of the impact section showed that n‐CeO2 can prevent crack propagation.
Strategies for the quality control of Chrysanthemi Flos: Rapid quantification and end‐to‐end fingerprint conversion based on FT‐NIR spectroscopy
Authors: Cui Tongcan , Ying Zehua , Zhang Jianyu , Guo Shubo , Chen Wei , Zhou Guifang , Li Wenlong 
Published: January 2024

AbstractIntroductionChrysanthemi Flos (CF) is widely used as a natural medicine or tea. Due to its diverse cultivation regions, CF exhibits varying quality. Therefore, the quality and swiftness in evaluation holds paramount significance for CF.ObjectiveThe aim of the study was to construct a comprehensive evaluation strategy for assessing CF quality using HPLC, near‐infrared (NIR) spectroscopy, and chemometrics, which included the rapid quantification analyses of chemical components and the Fourier transform (FT)‐NIR to HPLC conversion of fingerprints.Materials and methodsA total of 145 CF samples were utilised for data collection via NIR spectroscopy and HPLC. The partial least squares regression (PLSR) models were optimised using various spectral preprocessing and variable selection methods to predict the chemical composition content in CF. Both direct standardisation (DS) and PLSR algorithms were employed to establish the fingerprint conversion model from the FT‐NIR spectrum to HPLC, and the model's performance was assessed through similarity and cluster analysis.ResultsThe optimised PLSR quantitative models can effectively predict the content of eight chemical components in CF. Both DS and PLSR algorithms achieve the calibration conversion of CF fingerprints from FT‐NIR to HPLC, and the predicted and measured HPLC fingerprints are highly similar. Notably, the best model relies on CF powder FT‐NIR spectra and DS algorithm [root mean square error of prediction (RMSEP) = 2.7590, R2 = 0.8558]. A high average similarity (0.9184) prevails between predicted and measured fingerprints of test set samples, and the results of the clustering analysis exhibit a high level of consistency.ConclusionThis comprehensive strategy provides a novel and dependable approach for the rapid quality evaluation of CF.
Pharmacokinetic/pharmacodynamic modeling of cortical dopamine concentrations after quetiapine lipid core nanocapsules administration to schizophrenia phenotyped rats
Authors: Dias Bruna Bernar , Carreño Fernando , Helfer Victória Etges , Olivo Laura Ben , Staudt Keli Jaqueline , Paese Karina , Barreto Fabiano , Meyer Fabíola Schons , Herrmann Ana Paula , Guterres Sílvia Stanisçuaski , Rates Stela Maris Kuze , de Araújo Bibiana Verlindo , Trocóniz Iñaki F. , Dalla Costa Teresa 
Published: January 2024

AbstractSchizophrenia (SCZ) response to pharmacological treatment is highly variable. Quetiapine (QTP) administered as QTP lipid core nanocapsules (QLNC) has been shown to modulate drug delivery to the brain of SCZ phenotyped rats (SPR). In the present study, we describe the brain concentration–effect relationship after administrations of QTP as a solution or QLNC to SPR and naïve animals. A semimechanistic pharmacokinetic (PK) model describing free QTP concentrations in the brain was linked to a pharmacodynamic (PD) model to correlate the drug kinetics to changes in dopamine (DA) medial prefrontal cortex extracellular concentrations determined by intracerebral microdialysis. Different structural models were investigated to fit DA concentrations after QTP dosing, and the final model describes the synthesis, release, and elimination of DA using a pool compartment. The results show that nanoparticles increase QTP brain concentrations and DA peak after drug dosing to SPR. To the best of our knowledge, this is the first study that combines microdialysis and PK/PD modeling in a neurodevelopmental model of SCZ to investigate how a nanocarrier can modulate drug PK and PD, contributing to the development of new treatment strategies for SCZ.
On local ISS of nonlinear second‐order time‐delay systems without damping
Authors: Aleksandrov Alexander , Efimov Denis , Fridman Emilia 
Published: January 2024

SummaryFor a second‐order system with vector position, either constant or time‐varying delays, and a power nonlinearity of the degree higher than one, which does not contain a velocity‐proportional damping term, the conditions of local input‐to‐state stability are proposed. The result is based on application of Lyapunov‐Razumikhin approach, for which new time estimates on decay of solutions are obtained. The approach is extended to attitude stabilization of a rigid body, and it is illustrated by simulations.
Design and Motion Principle Analysis of new parallel mechanisms with fewer active inputs than the degrees of freedom
Authors: Wang Yu , Qiu Can , Wu Jiabin , Xu Yundou , Xi Fengfeng , Nie Shenglong , Zhao Yongsheng 
Published: January 2024

AbstractIn this paper, two new parallel mechanisms (PMs) with fewer active inputs than the degrees of freedom (DOFs)are proposed: (i) an nSPS (n = 7, 8, 9) six‐DOF PM with n‐6 active inputs and six lockable joints. and (ii) a 3RPS‐SPS 3‐DOF PM with one active input and three lockable joints. Compared with the traditional PMs, the difference is that the proposed PMs can achieve the same mobility by using a minimal number of active joints. Moreover, the load‐carrying capacity is also improved compared with the original standard mechanisms, since the new PMs become statically redundant when all the branches are locked. For this purpose, a sequential motion control principle is introduced that requires both inverse and forward kinematics of PMs. Kinematic modeling, dimensional optimization, and structural design are carried out for the 7SPS and 3RPS‐SPS mechanisms, and the two prototypes are constructed for experimental validation. Both simulation and experiment results have shown that the proposed hybrid PM can achieve the original mobility while significantly reducing the number of actuators.
A novel method for satellite prediction of VDE‐TER service traffic information based on multilayers bidirectional LSTM
Authors: Wu Ruiwen , Li Zongwang , Xie Zhuochen , Liang Xuwen 
Published: January 2024

SummarySatellite prediction of very high frequency (VHF) Data Exchange (VDE)‐Terrestrial (VDE‐TER) ship‐to‐ship Self‐Organized Networks (SON) service traffic information is crucial for wireless resource allocation of VHF Data Exchange System (VDES). Due to the VDE‐TER, channel load observed by the satellite changes rapidly and the historical information cached on the satellite is limited; the prediction of VDE‐TER service traffic is difficult. This paper proposes a multilayer bidirectional long short‐term memory (LSTM) neural network model (MLB‐LSTM), which controls the amount of forgetting of historical information and the amount of memory of current information through the LSTM unit, so that the model can better learn the nonlinear changes of service traffic. The bidirectional LSTM module combines forward and backward time series data, reducing the amount of data required for prediction and enhancing the prediction accuracy of the model. Numerical results show that the proposed prediction model significantly outperforms traditional methods and is able to adapt to rapidly changing VDE‐TER data.
Chemo‐Enzymatic Synthesis of Navarixin by Using Aqueous Micellar Media: A Greener Approach
Authors: Rajendra Gaikwad , Ganesh Krithika , Ravikumar Shashank C. , Rajulu Govinda G. , Sambasivam Ganesh , Shivashankarappa Nagashree 
Published: January 2024

AbstractA mild and scalable chemo‐enzymatic procedure for the synthesis of the anticancer drug navarixin was developed in aqueous micellar media. We herein, report a greener methodology for the synthesis of a key chiral amine intermediate in the synthesis of navarixin using transaminases. This was obtained in high yields with an enantiomeric excess of >99.9 %. The current synthetic method represents a mild and sustainable procedure to afford the chiral amine intermediate in a single step without the use of expensive chiral ligands and auxiliaries. Furthermore, the chiral amine was used in the synthesis of navarixin which was obtained in high yield and an enantiomeric excess of >97.7 %.
Carbon Dots as New Effective Catalysts for Knoevenagel Condensation Reaction and Synthesis of Cyclic Carbonates under Solvent‐free Conditions
Authors: Yu Jinfa , Luo Zhaoqin , Sun Xiangying 
Published: January 2024

AbstractCarbon dots (CDs) as new efficient catalysts have been developed for the Knoevenagel condensation reaction and the synthesis of cyclic carbonates under solvent‐free conditions. Six kinds of carbon dots with different numbers of amino groups were synthesized. The amine‐terminated carbon dot (NCDs‐1) was synthesized using arginine and ethylenediamine by a microwave technique, and its catalytic action was studied. NCDs‐1 with the highest numbers of amino groups was used as new metal‐free and effective heterogeneous catalysts to perform essential Knoevenagel condensation and cycloaddition reactions in solvent‐free conditions. 1H NMR was used to demonstrate the Knoevenagel condensation mechanism, in situ Fourier infrared spectroscopy was used to investigate CO2 cycloaddition and a catalytic mechanism was postulated. NCDs‐1 showed a yield of 96.3±1.5 % for Knoevenagel condensation of benzaldehyde and malononitrile. In addition, NCDs‐1/TBAB showed a yield of (97.0±1.0 %) of 4‐phenyl‐1,3‐dioxolan‐2‐one for styrene oxide at 100 °C and 0.1 MPa in 1.5 h. A simple and convenient method for catalytic reactions with amine‐terminated carbon dots was developed.
Ionic Liquid Immobilized Fe‐MIL‐101‐NH2 Efficiently Catalyzes the Chemical Fixation of CO2 with Epoxides to Form Cyclic Carbonates
Authors: Niu Junping , Zhang Daqing , Gao Xuechuan , Gao Yuanyuan , Wu Jiakai , Han Limin , Zhu Ning 
Published: January 2024

AbstractIn this work, two ionic liquids (ILs) immobilized metal‐organic frameworks (MOFs), Fe‐MIL‐101‐3N(BuBr) and Fe‐MIL‐101‐N(Bnme2)Br, were obtained by modifying amino groups in Fe‐MIL‐101‐NH2 with bromobutane and quaternary ammonium salt. The ionic liquid immobilized MOFs have Lewis acid sites (Fe3+) and nucleophilic sites (Br−), which can synergistically catalyze the cycloaddition reaction of CO2 and epoxides. Various cyclic carbonate derivatives were obtained in excellent yields under the optimal conditions. Additionally, we found that Fe‐MIL‐101‐N(Bnme2)Br exhibited the highest catalytic activity and it can be easily recovered and reused for at least 5 times without loss of catalytic activity. Our method of preparing bifunctional catalysts provides a new approach to design catalysts for the chemical conversion of CO2.
Utilizing Self‐Floating Cu3BiS3 Polydopamine Polyurethane Sponges for Enhanced Water Purification: Harnessing the free radical and non‐radical in persulfate system
Authors: Xiao Yi , Zhou Yi , He Wanhong , Huang Guihua , Feng Dujie , Xiang Minghui , Dang Mingming , Zhang Jin 
Published: January 2024

AbstractThe advanced oxidation process based on persulfate group is a promising technology for water purification. However, the synergistic effect of free radical and non‐free radical degradation is still not feasible in the persulfate activation process, which consumes a large amount of external energy. The self‐floating Cu3BiS3/polydopamine/polyurethane sponge was prepared using a simple method, resulting in high catalytic performance when activated by peroxydisulfate (PDS). The experiments conducted to identify free radicals showed that the degradation process of tetracycline (TC) involved the synergistic action of non‐radical 1O2 and free radicals (SO4⋅− and • OH) and the conversion of Cu+/Cu2+. The addition of Cl−, HCO3−, PO43−, and SO42− to the solution did not significantly affect the high degradation rate of TC. Furthermore, the interfacial evaporation process achieved a remarkable evaporation rate of 1.53 kg m−2 h−1 and produced reclaimed water without any detectable TC contaminants. The sponge also exhibited excellent salt resistance and chemical stability. This study provides valuable insights into the degradation of antibiotics and the desalination of seawater.