bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supramolecular Sidechain Topology Mediated Pseudo‐Nanophase Separation Engineering for High‐Performance Redox Flow Battery Membranes
Authors: Xiong Ping , Li Aimin , Xiao Sisi , Jiang Yunqi , Peng Sangshan , He Qing 
Published: November 2023

AbstractPseudo‐nanophase separation enabled by supramolecular‐interaction‐grafted sidechains proves a promising alternative for constructing high‐performance commercially viable membranes with quick ion transport, excellent chemical stability, and simplified membrane manufacturing. Nonetheless, the concept of pseudo‐nanophase separation is still in nuce, and determinants for controlling pseudo‐nanophase separation remain somewhat opaque. In this contribution, supramolecular sidechain topology is found critical to engineering pseudo‐nanophase separation. Three supramolecular sidechain topological (viz. linear, branched, and cyclic) structures are investigated using experimental and theoretical protocols, and the underlying mechanisms by which supramolecular sidechain topology alters the microstructure and ion‐conducting behaviors of the membranes are proposed. Consequently, the cyclic sidechain‐mediated membrane achieves the highest proton conductivity with an area resistance as low as 0.10 Ω cm2. The resulting membrane endows an acidic aqueous redox flow battery with an energy efficiency of up to 80.7% even at high current densities of 220 mA cm−2, breaking the record set by the pseudo‐nanophase separation strategy constructed membranes and ranking among the highest values ever documented. This study advances the understanding of supramolecular sidechain topology for the design and preparation of high‐performance membranes via pseudo‐nanophase separation engineering for flow batteries and beyond.
Leveraging the Proximity and Distribution of Cu−Cs Sites for Direct Conversion of Methanol to Esters/Aldehydes
Authors: Chen Wenyao , Zuo Ji , Sang Keng , Qian Gang , Zhang Jing , Chen De , Zhou Xinggui , Yuan Weikang , Duan Xuezhi 
Published: November 2023

AbstractMethanol serves as a versatile building‐block for various commodity chemicals, and the development of industrially promising strategies for its conversion remains the ultimate goal in methanol chemistry. In this study, we design a dual Cu−Cs catalytic system that enables a one‐step direct conversion of methanol and methyl acetate/ethanol into high value‐added esters/aldehydes, with customized chain length and saturation by leveraging the proximity and distribution of Cu−Cs sites. Cu−Cs at a millimeter‐scale intimacy triggers methanol dehydrogenation and condensation, involving proton transfer, aldol formation, and aldol condensation, to obtain unsaturated esters and aldehydes with selectivities of 76.3 % and 31.1 %, respectively. Cu−Cs at a micrometer‐scale intimacy significantly promotes mass transfer of intermediates across catalyst interfaces and their subsequent hydrogenation to saturated esters and aldehydes with selectivities of 67.6 % and 93.1 %, respectively. Conversely, Cu−Cs at a nanometer‐scale intimacy alters reaction pathway with a similar energy barrier for the rate‐determining step, but blocks the acidic‐basic sites and diverts the reaction to byproducts. More importantly, an unprecedented quadruple tandem catalytic production of methyl methacrylate (MMA) is achieved by further tailoring Cu and Cs distribution across the reaction bed in the configuration of Cu−Cs||Cs, outperforming the existing industrial processes and saving at least 15 % of production costs.
Characterization of polyhydroxybutyrate production from Halomonas titanicaeKHS3 and manufacturing of electrosprayed nanoparticles
Authors: Rodríguez Ailén N. , Escobar Mariana , Redersdorff Ingrid E. , Studdert Claudia A. , Abraham Gustavo A. , Cortez Tornello Pablo R. , Herrera Seitz M. Karina 
Published: November 2023

AbstractPolyhydroxyalkanoates (PHAs) are biopolymers accumulated by a diversity of bacterial strains as carbon and energy reserve when grown under unbalanced nutritional conditions. Among the wide spectrum of applications for these biopolymers, the generation of nano and microparticles has drawn huge attention. PHA nanoparticles showed a high surface‐to‐volume ratio that makes them interesting for pharmaceutical uses. Bacteria from the Halomonas genus became interesting tools for biopolymer production in the last years, due to its metabolic plasticity that allows them to grow in a wide spectrum of compounds and salt concentrations. Halomonas titanicae KHS3 was previously isolated based on their ability to grow using aromatic hydrocarbons as the sole carbon source. In this work, the novelty lies in the evaluation of PHA accumulation by H. titanicae KHS3. Accumulation was successfully observed and thoroughly characterized on various carbon sources. Irrespective of the carbon source employed for growth, our experimental conditions consistently yielded PHB as the sole material identified. The truly intriguing aspect of this study is that PHB solutions in glacial acetic acid demonstrated exceptional suitability for electrospraying processing. This groundbreaking development led to the creation of nanoparticles with unique characteristics that hold immense promise for a wide range of applications.
Tailoring Chiral Discotic Liquid Crystals: Mesophase Engineering through Alternative Approaches and Chain Lengths
Authors: Maity Madhusudan , Bala Indu , Kanakala Madhu Babu , Gupta Santosh Prasad , Yelamaggad C. V. , Pal Santanu Kumar 
Published: November 2023

AbstractHydrogen (H)‐bonding is crucial in constructing superstructures in chemical (such as chiral discotic liquid crystals (DLCs)) as well as in biological systems due to its specific and directional nature. In this context, we achieved the successful synthesis of two branches of heptazine‐based H‐bonded complexes using distinct strategies. Hpz*‐Es‐Cn, we incorporated chiral alkyl tails (Hpz‐chiral) onto the central C3 symmetric heptazine core, connected to achiral benzoic acid derivatives (Es‐Cn acid) through H‐bonding. In Hpz‐Es‐Cn‐acid*, we used an achiral heptazine derivative (Hpz‐Es‐Cn) linked to a chiral acid via H‐bonding. On the other hand, based on the DSC results, we observed that Hpz*‐Es‐Cn complexes exhibited three distinct phases, whereas Hpz‐Es‐Cn‐acid* complexes displayed only a single mesophase. In polarized optical microscopy (POM) observations, all the complexes displayed birefringence at room temperature, with the color of the POM images changing as the temperature varied. X‐ray diffraction (XRD) studies at lower temperatures confirmed that Hpz*‐Es‐C8 exhibited the columnar rectangular (Colr) phase, while Hpz*‐Es‐C10/12 exhibited the columnar oblique (Colob) phase. However, all the H‐bonded complexes exhibited the columnar hexagonal (Colh) phase at higher temperatures. The chiroptical spectra recorded by Circular dichroism (CD) highlight the specific observations in the columnar phase of two complexes, Hpz*‐Es‐C10 and Hpz*‐Es‐C12. This behavior has potential applications in various fields, including sensors, displays, and responsive materials.
The mutational pattern of homologous recombination repair genes in urothelial carcinoma and its correlation with immunotherapeutic response
Authors: Chen Junru , Tang Yanfeng , Liu Huanhuan , Sun Guangxi , Liu Haoyang , Zhao Junjie , Wang Zilin , Zhang Yanrui , Lou Feng , Cao Shanbo , Qin Jiayue , Wang Huina , Liao Banghua , Zeng Hao 
Published: November 2023

AbstractBackgroundThe mutational pattern of homologous recombination repair (HRR)‐associated gene alterations in Chinese urothelial carcinoma (UC) necessitates comprehensive sequencing efforts, and the clinical implications of HRR gene mutations in UC remain to be elucidated.Materials and MethodsWe delineated the mutational landscape of 343 Chinese UC patients from West China Hospital and 822 patients from The Cancer Genome Atlas (TCGA) using next‐generation sequencing (NGS). Data from 182 metastatic UC patients from MSK‐IMPACT cohort were used to assess the association between HRR mutations and immunotherapy efficacy. Comprehensive transcriptomic analysis was performed to explore the impact of HRR mutations on tumor immune microenvironment.ResultsAmong Chinese UC patients, 34% harbored HRR gene mutations, with BRCA2, ATM, BRCA1, CDK12, and RAD51C being the most prevalently mutated genes. Mutational signatures contributing to UC differed between patients with and without HRR mutations. Signature 22 for exposure to aristolochic acid was only observed in Chinese UC patients. The presence of HRR mutations was correlated with higher tumor mutational burden, neoantigen burden, and PD‐L1 expression. Importantly, patients with HRR mutations exhibited significantly improved prognosis following immunotherapy compared to those without HRR mutations.ConclusionsOur findings provide valuable insights into the genomic landscape of Chinese UC patients and underscore the molecular rationale for utilizing immunotherapy in UC patients with HRR mutations.
Transient EDTA‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact
Authors: Watanabe Ayako , Toshima Hirokazu , Saeki Misa , Nagata Takuya , Koyanagi Tatsuo , Minamizawa Masumi , Kashiwabara Yuka , Kobayashi Koji , Shimada Ken , Momo Kenji 
Published: November 2023

Key Clinical MessageEDTA‐dependent pseudothrombocytopenia as well as myelosuppression should be suspected when thrombocytopenia occurs in patients with autoimmune disease during chemotherapy.AbstractA patient with pancreatic cancer and ulcerative colitis developed transient ethylenediaminetetraacetic acid (EDTA)‐dependent pseudothrombocytopenia with exacerbation of ulcerative colitis during chemotherapy. Unfortunately, pseudothrombocytopenia could not be immediately detected because thrombocytopenia was masked by a reasonable time course of adverse events associated with chemotherapy and ulcerative colitis recurrence. When thrombocytopenia occurs during chemotherapy, especially in patients with autoimmune diseases, EDTA‐dependent pseudothrombocytopenia and bone marrow suppression caused by anti‐cancer agents should be suspected.
Well‐differentiated liposarcoma of tongue: A case report
Authors: Singh Moushami , Napit Arun R. , Piya Gunja , Thakur Prabhat Chandra , Mohanty Sambit , Shinde Sayali , Jain Ekta , Dhakal Hari Prasad 
Published: November 2023

Key Clinical MessageIt is important to consider WDLS as a potential cause of tongue lesions and include it in the list of differential diagnoses. When performing surgical intervention, it is crucial to remove enough tissue around the lesion, and regular follow‐up is necessary due to the high risk of recurrence, despite its rarity, when margins are positive.AbstractLiposarcoma (LS) is the most common soft tissue sarcomas (STSs) that arise from embryonic mesenchymal tissue. Though these sarcomas commonly arise at retroperitoneal locations and extremities, the appearance of these tumors in the head and neck region is rare, with the tongue as a preferred site. As per WHO 2020, LS is classified into four subtypes based on morphology, namely, Well‐differentiated liposarcoma (WDLS), Dedifferentiated liposarcoma (DDLS), Myxoid liposarcoma (MLS), and Pleomorphic liposarcoma (PLS). WLS is the most common variant among all. Here, we had a case of 55 years old male with the complaint of swelling in the left lateral border of the tongue with the preliminary diagnosis of pleomorphic adenoma. The patient underwent a left partial glossectomy with adequate margins. Further evaluation of the lesion revealed a clear cell tumor that was ultimately confirmed as liposarcoma on immunohistochemistry that showed tumor cells positive for S100, CDK4, and MDM2 with 2% Ki‐67. Postsurgical status of the patient was evaluated by F18 FDG PET CTscan, which was normal. Currently, the patient is under regular follow‐up.
Multielectron Redox Afforded by a Pincer Ligand Promoting Kumada Cross‐Coupling Reactions
Authors: Singh Vikramjeet , Jain Harshit , Nath Shounak , Adhikari Debashis 
Published: November 2023

AbstractThe redox‐active nature of a pincer has been exploited to conduct C−C cross‐coupling reactions under mild conditions. A nickel complex with a NNN pincer was dimeric in the solid state, and the structure displayed a Ni2N2 diamond core. In the dimeric structure, both ligand backbones house an electron, in the iminosemiquinonate form, to keep the metal's oxidation state at +2. In the presence of an aryl Grignard reagent, only 3 mol % loading the nickel complex generates a Kumada cross‐coupled product in good yield from a wide variety of aryl‐X (X= I, Br, Cl) substrates. That the ligand‐based radical remains responsible for promoting such a coupling reaction following a radical pathway is suggested by TEMPO quenching. Furthermore, a radical‐clock experiment along with tracing product distribution unambiguously supported the radical's involvement through the catalytic cycle. A series of thorough mechanistic probation, including computational DFT analysis, disclosed the cooperative action of both redox‐active pincer ligand and the metal centre to drive the reaction.
Nonclinical factors associated with the treatment of older women with newly diagnosed low‐grade ductal carcinoma in situ
Authors: DeLeire Thomas , Mitchell Jean M. , De La Cruz Lucy , Isaacs Claudine 
Published: November 2023

AbstractBackgroundDuctal carcinoma in situ (DCIS) is the most common form of noninvasive breast cancer and is associated with an excellent prognosis. As a result, there is concern about overdiagnosis and overtreatment of DCIS because most patients with DCIS are treated as though they have invasive breast cancer and undergo either breast‐conserving surgery (BCS)—most commonly followed by radiation therapy (RT)—or mastectomy. Little research to date has focused on nonclinical factors influencing treatments for DCIS.MethodsPopulation‐based data were analyzed from five state cancer registries (California, Florida, New Jersey, New York, and Texas) on women aged 65 years and older newly diagnosed with DCIS during the years 2003 to 2014 using a retrospective cohort design and multinominal logistic modeling. The registry records with Medicare enrollment data and fee‐for‐service claims to obtain treatments (BCS alone, BCS with RT, or mastectomy) were merged. Surgeon practice structure was identified through physician surveys and internet searches.ResultsPatients of surgeons employed by cancer centers or health systems were less likely to receive BCS with RT or mastectomy than patients of surgeons in single specialty or multispecialty practices. There also was substantial geographic variation in treatments, with patients in New York, New Jersey, and California being less likely to receive BCS with RT or mastectomy than patients in Texas or Florida.ConclusionsThese findings suggest nonclinical factors including the culture of the practice and/or financial incentives are significantly associated with the types of treatment received for DCIS. Increasing awareness and targeted efforts to educate physicians about DCIS management among older women with low‐grade DCIS could reduce patient harm and yield substantial cost savings.
Strategies in Aggregation Tests for Rare Variants
Authors: Rajabli Farid , Kunkle Brian W. 
Published: November 2023

AbstractGenome‐wide association studies (GWAS) successfully identified numerous common variants involved in complex diseases, but only limited heritability was explained by these findings. Advances in high‐throughput sequencing technology made it possible to assess the contribution of rare variants in common diseases. However, study of rare variants introduces challenges due to low frequency of rare variants. Well‐established common variant methods were underpowered to identify the rare variants in GWAS. To address this challenge, several new methods have been developed to examine the role of rare variants in complex diseases. These approaches are based on testing the aggregate effect of multiple rare variants in a predefined genetic region. Provided here is an overview of statistical approaches and the protocols explaining step‐by‐step analysis of aggregations tests with the hands‐on experience using R scripts in four categories: burden tests, adaptive burden tests, variance‐component tests, and combined tests. Also explained are the concepts of rare variants, permutation tests, kernel methods, and genetic variant annotation. At the end we discuss relevant topics of bioinformatics tools for annotation, family‐based design of rare‐variant analysis, population stratification adjustment, and meta‐analysis. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.
The Enhanced Photo‐Catalytic Properties of ZnO Under the Synergistic Effect of CaCO3
Authors: Yao Chengli , Chen Chen , Yuan Yijin , Zhu Wenjuan , Tai Wenqing , Ding Can , Li Hongying 
Published: November 2023

AbstractAt present, the problem of environmental pollution is becoming increasingly serious. It is urgent to develop efficient catalysts to solve these problems. To obtain the functional characteristics of CaCO3 and promote its application in coatings and photo‐catalysis, ZnO/CaCO3 particles are prepared by the solution co‐precipitation method under the mediate of sodium dodecyl sulfate (SDS) through corresponding strategies. The structures and morphologies of samples are characterized by XRD, FT‐IR, SEM, and TEM, respectively. Besides that, the photo‐catalytic property of the desired product is also evaluated. The results indicate that SDS helps to induce the formation of porous structure. Through co‐precipitation, ZnO particles uniformly load on porous calcium carbonate. ZnO/CaCO3 particles are endowed with low‐cost property and high catalytic performance under the synergistic effect of photo‐catalytic properties and absorption abilities. This work established a simple way to produce the composite catalysts with low price and high photo‐catalytic activity.
The 5 E(lements) of employee‐centric corporate social responsibility and their stimulus on happiness at work: An empirical investigation
Authors: Kocollari Ulpiana , Cavicchioli Maddalena , Demaria Fabio 
Published: November 2023

AbstractIn recent times, there has been a growing interest in corporate social responsibility (CSR) practices that focus on employees, with an increasing emphasis on investigating employees' experiences of CSR in relation to their happiness. The purpose of this study is to explore employee‐centric CSR initiatives with the aim of identifying the elements stimulating happiness at work (HAW). To accomplish this, we adopt a non‐linear and data‐driven approach to analyze self‐reported data from 441 employees across 21 small and medium‐sized enterprises spanning various industries. The analysis brings to light 5 E(lements) of employee‐centric CSR: envisioning, related to personal and organizational value orientation; equity, related to definition and distribution of rewards; empowerment, related to career development and professional growth; experimentation, related to innovative tasks and organizational forms; and empathy, related to a supportive workplace and coworkers' network. These 5 E(lements) serve as stimuli for HAW in different ways: envisioning, empowerment, and experimentation play a major role in promoting employees' happiness and underscore the importance of initiatives related to shared values, inclusivity, and innovative work practices. Thus, this study sheds light on the influence of employee‐centric CSR in promoting HAW and on effective strategies that may contribute to achieving Sustainable Development Goals targets.
Advances in device‐based treatment of heart failure with preserved ejection fraction: evidence from clinical trials
Authors: Wu Ying , Song Meiyan , Wu Meifang , Lin Liming 
Published: November 2023

AbstractHeart failure with preserved ejection fraction (HFpEF) is a group of clinical syndromes that exhibit a remarkably heterogeneous phenotype, characterized by symptoms and signs of heart failure, left ventricular diastolic dysfunction, elevated levels of natriuretic peptides, and an ejection fraction greater than or equal to 50%. With the aging of the population and the escalating prevalence of hypertension, obesity, and diabetes, the incidence of HFpEF is progressively rising. Drug therapy options for HFpEF are currently limited, and the associated high risk of cardiovascular mortality and heart failure rehospitalization significantly impact patients' quality of life and longevity while imposing a substantial economic burden on society. Recent research indicates that certain device‐based therapies may serve as valuable adjuncts to drug therapy in patients with specific phenotypes of HFpEF, effectively improving symptoms and quality of life while reducing the risk of readmission for heart failure. These include inter‐atrial shunt and greater splanchnic nerve ablation to reduce left ventricular filling pressure, implantable heart failure monitor to guide diuresis, left atrial pacing to correct interatrial dyssynchrony, cardiac contractility modulation to enhance cardiac calcium handling, as well as renal denervation, baroreflex activation therapy, and vagus nerve stimulation to restore the autonomic imbalance. In this review, we provide a comprehensive overview of the mechanisms and clinical evidence pertaining to these devices, with the aim of enhancing therapeutic strategies for HFpEF.
Weak grip strength predicts higher unplanned healthcare utilization among patients with heart failure
Authors: Poco Louisa Camille , Finkelstein Eric , Sim David , Malhotra Chetna 
Published: November 2023

AbstractAimsFrailty increases healthcare utilization and costs for patients with heart failure but is challenging to assess in clinical settings. Hand grip strength (GS) is a single‐item measure of frailty yet lacks evidence as a potential screening tool to identify patients at risk of higher unplanned events and related healthcare costs. We examined the association of baseline and longitudinal GS measurements with healthcare utilization and costs among patients with advanced heart failure.Methods and resultsBetween July 2017 and April 2019, we enrolled 251 patients with symptoms of advanced heart failure (New York Heart Association class III or IV) in a prospective cohort study in Singapore. We measured GS at baseline and every 4 months for 2 years and linked patients' survey data with their medical and billing records. We categorized patients as having weak GS if their GS measurement was below the 5th percentile of the age‐ and gender‐specific normative GS values in Singapore. We assessed the association between baseline GS and healthcare utilization (unplanned and planned events and healthcare costs, total costs, and length of inpatient stay) over the next 2 years using regression models. We investigated the association between longitudinal 4‐monthly GS assessments and the ensuing 4 months of healthcare utilization and costs using mixed‐effects logistic and two‐part regression models. At baseline, 22.5% of patients had weak GS. Baseline and longitudinal GS measurements were significantly associated with longer length of inpatient stay, greater likelihood of unplanned events, and higher related costs. Patients with weak GS had higher odds of an unplanned event occurring by 8 percentage points [95% confidence interval (CI) (0.01, 0.14), P = 0.026], incurred longer inpatient stays by 4 days [95% CI (1.97, 6.79), P = 0.003], and additional SG$ 4792 [US$ ~ 3594, 95% CI (1894, 7689), P = 0.014] in unplanned healthcare costs over the next 4 months.ConclusionsGS is a simple tool to identify and monitor heart failure patients at risk of unplanned events, longer inpatient stays, and higher related healthcare costs. Findings support its routine use in clinical settings.