bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of accelerated high-fluence riboflavin and rose bengal-mediated corneal cross-linking on resistance to enzymatic digestion
Authors: Hafezi Nikki L. , Aydemir M. Enes , Lu Nan-Ji , Torres-Netto Emilio A. , Hillen Mark , Koppen Carina 
Published: January 2024

Abstract
Purpose
This study evaluated the effect of high-fluence accelerated corneal cross-linking on the resistance to enzymatic digestion, assessing two chromophore/light combinations: riboflavin/UV-A light (RF/UV-A) and rose bengal/green light (RB/green).

Methods
Freshly prepared ex-vivo porcine corneas (n = 189) were divided into 8 groups groups. Group A corneas were unirradiated controls without chromophore soaking (A0), or soaked with riboflavin (A1) or rose bengal (A2). Group B corneas underwent accelerated epi-off RF/UV-A CXL at fluences of 5.4 J/cm² (B1), 10 J/cm² (B2), or 15 J/cm² (B3). Group C corneas underwent accelerated epi-off RB/green CXL at fluences of either 10 J/cm² (C1) or 15 J/cm² (C2). Following CXL, all corneas were digested in 0.3% collagenase-A solution, and the time until complete dissolution was measured.

Results
Non-irradiated controls exposed to RF and RB enhanced corneal resistance to collagenase digestion, with RB having a stronger effect than RF. RF/UV-A-treated corneas showed significantly increased digestion resistance with increasing fluence levels. RB/green-treated corneas displayed enhanced digestion resistance with each increase in fluence up to 10 J/cm²; a 15 J/cm² fluence yielded similar digestion resistance times to a 10 J/cm² fluence, suggesting a plateau effect in accelerated RB/green CXL protocols.

Conclusions
When compared to standard-fluence treatments, high-fluence accelerated epi-off CXL using both riboflavin and rose bengal significantly increases resistance to enzymatic digestion. The optimal settings for clinical protocols might be 15 J/cm² (30 mW/cm² for 8 min 20 s) for RF/UV-A and 10 J/cm² (15 mW/cm² for 11 min 7 s) for RB/Green Light.
SOCS5, targeted by miR-155-5p, plays a negative regulatory role in pulmonary hypertension through inhibiting JAK2/STAT3 signaling pathway
Authors: Sun Lili , Liu Lihua , Liang Dongxue , Liu Linlin 
Published: January 2024

AbstractPulmonary hypertension (PH) is a chronic pulmonary vascular disease and causes massive deaths. Here, we intended to investigate the function and mechanism of SOCS5 in PH. We engineered a hypoxia-induced PH model in mice. HE staining were implemented to evaluate pathological alterations in the lung tissues. The potential mechanism of SOCS5 in regulating hypoxia-induced pulmonary artery smooth muscle cell (PASMC) function was explored in vitro. RT-qPCR and western blot revealed that the level of SOCS5 was decreased both in PH mice and hypoxia-induced HPASMCs. Functional assays were performed for confirming the role of SOCS5 in modulating the cell phenotype and JAK2/STAT3 pathway in HPASMCs. Results revealed that overexpression of SOCS5 suppressed proliferation, migration and contraction of HPASMCs and negatively regulated the JAK2/STAT3 signaling pathway in HPASMCs under hypoxia in vitro, while knockdown of SOCS5 accelerated it. As evidenced by mechanism studies, SOCS5 was targeted and regulated by miR-155-5p, hence affecting on HPASMC proliferation, migration and contraction. These outcomes indicated that the decreased level of SOCS5 in hypoxia-induced HPASMCs promoted the cell proliferation, cell migration, and cell contraction through activating JAK2/STAT3 signaling pathway. Moreover, SOCS5 was targeted by miR-155-5p. All in all, our work hinted that miR-155-5p/SOCS5/JAK2/STAT3 axis played a crucial part in PH.
Infantile hemangioma in a subadult Chinese pangolin: a case report
Authors: Wang Xianghe , Xu Xuelin , An Fuyu , Ren Zhengyu , Li Yongzheng , Wang Kai , Hua Yan 
Published: January 2024

Abstract
Background
Hemangiomas are a relatively common type of tumor in humans and animals. Various subtypes of hemangiomas have been described in the literature. The classification methods for hemangiomas differ between human and veterinary medicine, and the basis for tumor classification can be found in the literature.

Case presentation
This study describes a tumor in the subcutaneous tissue of the right dorsum of an artificially rescued juvenile Chinese pangolin. Computed tomography (CT) examination yielded the preliminary diagnosis of a vascular malformation, and surgery was performed to resect the tumor. Histopathological examination showed that the tumor mainly was consisted of adipose tissue, capillaries, and spindle cells in the fibrous stroma. Immunohistochemistry showed the positive expression of CD31, CD34, α-SMA, GLUT1 and WT-1 in the tumor tissue, and the tumor was eventually diagnosed as an infantile haemangioma.

Conclusion
The final diagnosis of infantile hemangioma was depended on the histopathological immunohistochemical and CT examination of the neoplastic tissue. This is the first report of infantile hemangioma in a critically endangered species Chinese pangolin.
Demodicosis in a Kunekune pig and molecular characterisation of porcine demodectic mites involved: a case report
Authors: Schwarz Lukas , Herb Verena , Dürlinger Sophie , Martin Vera , Poláková Nina , Horvath-Ungerböck Christa , Brunthaler Rene , Knecht Christian , Dippel Maximiliane , Pikalo Jutta , Ladinig Andrea , Joachim Anja , Fuehrer Hans-Peter 
Published: January 2024

Abstract
Background
In January 2021, a female 1-year-old Kunekune was presented at the University Clinic for Swine with severe reduction of the field of vision resulting in prolonged reaction time when targeting barriers, due to moderate to severe thickening of the skin around both orbits also affecting the eyelids.

Methods
Clinical examination revealed skin hyperplasia, nodular enlargement of the skin pores of the axillar and inguinal region. Ophthalmologists decided to remove parts of the thickened periocular skin, followed by histopathological examination.

Results
Once large amounts of demodectic mites were detected by histopathology, demodicosis could be diagnosed and treatment of the pig was started using sarolaner. Morphological and molecular analyses were performed. Histopathological and parasitological exams led to the aetiological diagnosis of demodicosis in the affected Kunekune pig. Severe skin lesions were revealed to be the consequence of an infestation with Demodex sp. Morphological analyses confirmed the involvement of D. phylloides. Molecular characterization indicated a Demodex species closely related to mites documented in wild boar - most probably D. phylloides for which no explicit sequences are available in GenBank yet. Treatment with sarolaner (2.6 mg/kg) resulted in a substantial regression of skin lesions, already detectable 1 month after first treatment.

Conclusions
Demodicosis is a very rare disease in pigs that is most probably related to an impaired immune response to the mites. Demodectic mange should be included in the list of differential diagnoses in cases of periocular alterations of the skin of pigs.

Graphical Abstract
The predicament of social sciences in the 20th century: a dialogue with Clifford Geertz’s essay “Thick description: toward an interpretive theory of culture” (Part I)
Authors: Cai Hua 
Published: January 2024

AbstractThe theorization of social sciences in the 20th century walked forward with difficulty. Clifford Geertz’s essay, “Thick description: Toward an interpretive theory of culture”, which comprehensively explored the fundamental problems in the process, is an essential document in the history of thoughts in the social sciences in the twentieth century. In response to Geertz’s reflection, this paper tries to reveal the predicament of interpretive anthropology and the entire social sciences and its methodological roots through an epistemological analysis of social science.
Contribution of neuroimaging in late-life depression
Authors: Desmidt T. 
Published: January 2024

Abstract
Late-life depression (LLD) is currently a hot topic for neuroimaging studies, while an increasing number of imaging modalities are now available for the characterization of brain structure and function. Changes in brain volumes, including hippocampal volume, have been observed in LLD, although results are inconsistent. Vascular lesions are more consistently associated with LLD and may constitute factors of poor prognosis. More recent MRI modalities, including fMRI and DTI, also show interesting results, notably to assess treatment response in LLD. Molecular Imaging also has the potential to improve our understanding of the pathophysiology of LLD, using imaging such as PET-FDG and Amyloid PET. Finally, there are emerging studies with novel neuroimaging modalities such as Ultrasound to measure subtle mechanical properties in the brain of patients with LLD. Finally, we contend that neuroimaging has the potential to provide markers for the identification of subcategories of LLD (vascular depression, amyloid depression, etc.) as well as prognostic values and markers for treatment response.

Disclosure of Interest
None Declared
FUNCTIONAL ROLE OF GASTRONOMIC AUSTRICISMS IN A LITERARY TEXT
Authors: Akasheva Tatiana V. , Rakhimova Nuriya M. , Zharkova Alexandra D. 
Published: January 2024

Background. The Austrian Reading Room Organized, which was founded on the basis of MSTU named after G.I. Nosov more than 10 years ago, has become a platform for the implementation of educational, career guidance, cultural and scientific projects, providing university students with the opportunity to read both classical and modern Austrian literature.
However, when reading, students often experience difficulties as texts normally contain typical Austrian lexemes and expressions due to the pluricentric nature of the German language. In this regard, there is a need for a linguistic analysis of the territorial functioning of the German language in Austria from the standpoint of an adequate understanding and interpretation of a literary text, which explains the relevance of addressing this topic.
Purpose. To identify and typologize austricisms that express gastronomic names being relevant for understanding and interpreting a literary text, as well as to analyze their functional load in the space of a literary text.
Materials and methods. The main research methods are the analysis of scientific literature by Russian and foreign scientists on the problem of the pluricentricity German language, continuous sampling, functional analysis of text fragments, and contextual analysis.
Research results. During the study, texts of classical and modern Austrian literature were analyzed, gastronomic austricisms were identified and typologized, and their functional load in a literary text was described.
Practical implications. The results obtained can be used when reading Austrian fiction for a deeper interpretation, as well as when teaching students German as a foreign language.
FUNCTIONAL FEATURES OF COMPOSITIONAL CONJUNCTIONS USE IN A SCIENTIFIC MEDICAL TEXT
Authors: Tkacheva Raisa A. , Kuznetsova Anzhelika A. , Axenova Ekaterina D. , Mihailova Natalya D. 
Published: January 2024

Background. The article is devoted to the use of means of compositional conjunctions in the field of scientific communication on the example of the a in a simple sentence. The authors refer to the semantic and functional features of the compositional conjunction a in the scientific medical text, where it is presented quite widely. The comparative meaning of the conjunction a, the specifics and rules of verbalization of this meaning are focused on the most accurate and specific characterization of the facts occurring in a living organism or in any part of it.
The purpose of the study is to present a variety of options for the characteristics of the objects of comparison, a detailed examination of the functioning of various words-allied analogues used together with the conjunction a, i.e., a vmeste s tem (and at the same time), a sledovatel'no, a znachit (and therefore), which means and others, among which special attention is paid to sentences with a combination and also.
Materials and methods. Textbooks served as the material for the study are as follows: N.V. Chebyshev Biology (2016), Human Physiology, ed. V.M. Smirnov (2019), G.V. Poriadin et al. Pathophysiology. General and Clinical Pathophysiology (2022). The article used methods of scientific description, observation and statistical analysis, which allowed us to obtain reliable information about the functioning of the composition conjunction a in a scientific text of a medical profile.
Results. The article concludes that the compositional conjunction a is capable of creating diverse semantic relations in a scientific text of a medical profile and performing specific communicative tasks of text formation. The functioning of the conjunction a in a simple sentence is associated with the accentuation of one of the connected fragments, which, as a rule, finds expression in the more frequent connection of concertizers to the conjunction a. The informative and communicative status of adjunctive sentences with a-relations in scientific speech is aimed at a more accurate and adequate presentation of scientific information.
Practical implications. The results may be used not only for following research of scientific (medical) text but are also important in the pedagogical practice of teaching foreign medical students.
Cadernos de caligrafia — nº 1 | nº 2 | nº 3 | nº 4 | nº 5
Authors: Braga L. Hansen 
Published: January 2024

O presente ensaio dispõe, lado a lado, repetições caligráficas em que se mostra irrevogável a dimensão imagética da escritura. Nesses exercícios, o corpo é colocado em situações escriturárias contraintuitivas: o uso da mão não dominante (caderno nº 1); a caligrafia cursiva com ligação completa entre as palavras (nº 2); a direção invertida do ato, ou seja, da direita para esquerda (nº 3); a letra cursiva intercalada com a letra de imprensa (nº 4) e a caminhada (nº 5 ).
Clinical experience sharing on gastric microneuroendocrine tumors: A case report
Authors: Wang You-Jun , Fan Da-Ming , Xu Yu-Shuang , Zhao Qi , Li Zhen-Fang 
Published: January 2024

BACKGROUND
The majority of gastric neuroendocrine tumors (G-NENs) are present in various lesions under endoscopy, and they can be polypoid uplifts, submucosal tumors or papules, erosions, and ulcers. The lesions are mostly confined to the mucosal or submucosal layer, usually less than 2 cm, and exclusively localized to the gastric body or fundus. In type 1 G-NENs, about 22% of cases have no visible lesions under an endoscope, and such lesions can only be detected via biopsies (microcarcinoids).
CASE SUMMARY
A 67-year-old female patient with appetite loss for more than half a year and personal history of hyperthyroidism was admitted to our hospital. After admission, a random multi-point biopsy was performed on the gastric body, fundus, angle, and antrum through gastroscopy. Pathological examination showed chronic severe atrophic gastritis in the fundus and body of the stomach. The small curvature of the gastric body, the anterior wall of the gastric body, and the posterior wall of the gastric body displayed proliferation of intestinal chromaffin cells. The curvature of the gastric body showed neuroendocrine tumor G1 (carcinoid), while the antrum and angle of the stomach showed mild atrophic gastritis with mild intestinal metaplasia. Immunohistochemical examination showed that the greater curvature of the gastric body was Syn (+), CgA (+), and Ki-67 (+, approximately 1%), which is consistent with neuroendocrine tumors (grade 1). Regular gastroscopy and biopsy should be performed every one to two years to monitor G-NENs.
CONCLUSION
In the case under study, the patient did not have any visible raised lesions under a gastroscope, and the lesions were found only after a random biopsy. This article combines the endoscopic manifestations and clinical features of the lesions in this case to improve the diagnosis of G-NENs.
Endoscopic retrograde appendicitis treatment for periappendiceal abscess: A case report
Authors: Li Qiao-Mei , Ye Bin , Liu Jun-Wei , Yang Shang-Wen 
Published: January 2024

BACKGROUND
Acute appendicitis is the most common abdominal emergency. At present, the main treatments for periappendiceal abscess include antibiotics and surgery. However, the complications and mortality of emergency surgery are high. The preferred therapy is conservative treatment with antibiotics first, ultrasound-guided puncture drainage or surgical treatment is followed when necessary. Endoscopic retrograde appendicitis therapy (ERAT) for acute uncomplicated appendicitis have been proved clinically effective, but it is rarely used in periappendiceal abscess.
CASE SUMMARY
We report a patient admitted to hospital because of “right lower abdominal pain for six days”. The computerized tomography (CT) of patient showed that appendicitis with fecaliths and abscess in the pelvis. The patient was treated by CT-guided puncture and drainage of abdominal abscess combined with ERAT to remove appendiceal fecaliths, irrigation and stent placement.
CONCLUSION
The patient did not receive surgery because of impoverished family. Abdominal pain did not recur during the follow-up period. This case confirms the value of ERAT in the treatment of periappendiceal abscess.
Developmental Perspectives on Transitions at Age 60: Individuals Navigating Across the Lifespan (TRAILS) – latest data collection in a longitudinal JYLS study
Authors: Kokko Katja , Fadjukoff Päivi , Reinilä Emmi , Ahola Johanna , Kinnunen Marja-Liisa , Kroger Jane , Laakkonen Eija K. , Pitkänen Tuuli , Pulkkinen Lea , Rantanen Taina , Staudinger Ursula M. , Taipale Sakari , Törmäkangas Timo , Kekäläinen Tiia , Saajanaho Milla 
Published: January 2024

At around age 60, people are approaching late adulthood and are typically going through or anticipating life transitions such as grandparenthood, retirement, or changes in health and functioning. The timing and perception of transitions are individual and based on current circumstances and earlier life history and may link to well-being. The TRAILS (Developmental Psychological Perspectives on Transitions at Age 60: Individuals Navigating Across the Lifespan) study, which is presented in the current article, examines the diversity and underlying factors of different transitions at around age 60 and how they associate with mental well-being. It also investigates whether these transitions link to personality characteristics, contextual resources, and/or societal challenges. The role of earlier life history in the studied associations requires a prospective multiwave design where the same participants are followed over time. Only a few longitudinal studies have examined the developmental pathways from childhood to the beginning of late adulthood.
The TRAILS study continues the Jyväskylä Longitudinal Study of Personality and Social Development (JYLS). The JYLS was initiated in 1968 and includes earlier data collected from ages 8 to 50. At age 61, in 2020–21, 206 of the JYLS participants (of the initial 369 children) took part in TRAILS. The data collection included a Life Situation Questionnaire, a psychological interview, self-report inventories, a health examination and physical activity surveillance covering major areas of adult life. TRAILS extends the JYLS study to over 52 years of follow-up time and provides unique opportunities for studying individual development throughout the lifespan.
Re-testing as a method of implementing external quality assessment program for COVID-19 real time PCR testing in Uganda
Authors: Okek Erick Jacob , Masembe Fredrick Joshua , Kiconco Jocelyn , Kayiwa John , Amwine Esther , Obote Daniel , Alele Stephen , Nahabwe Charles , Were Jackson , Bagaya Bernard , Balinandi Stephen , Lutwama Julius , Kaleebu Pontiano 
Published: January 2024

Background
Significant milestones have been made in the development of COVID19 diagnostics Technologies. Government of the republic of Uganda and the line Ministry of Health mandated Uganda Virus Research Institute to ensure quality of COVID19 diagnostics. Re-testing was one of the methods initiated by the UVRI to implement External Quality assessment of COVID19 molecular diagnostics.

Method
participating laboratories were required by UVRI to submit their already tested and archived nasopharyngeal samples and corresponding meta data. These were then re-tested at UVRI using the WHO Berlin protocol, the UVRI results were compared to those of the primary testing laboratories in order to ascertain performance agreement for the qualitative & quantitative results obtained. Ms Excel window 12 and GraphPad prism ver 15 was used in the analysis. Bar graphs, pie charts and line graphs were used to compare performance agreement between the reference Laboratory and primary testing Laboratories.

Results
Eleven (11) Ministry of Health/Uganda Virus Research Institute COVID19 accredited laboratories participated in the re-testing of quality control samples. 5/11 (45%) of the primary testing laboratories had 100% performance agreement with that of the National Reference Laboratory for the final test result. Even where there was concordance in the final test outcome (negative or positive) between UVRI and primary testing laboratories, there were still differences in CT values. The differences in the Cycle Threshold (CT) values were insignificant except for Tenna & Pharma Laboratory and the UVRI(p = 0.0296). The difference in the CT values were not skewed to either the National reference Laboratory(UVRI) or the primary testing laboratory but varied from one laboratory to another. In the remaining 6/11 (55%) laboratories where there were discrepancies in the aggregate test results, only samples initially tested and reported as positive by the primary laboratories were tested and found to be false positives by the UVRI COVID19 National Reference Laboratory.

Conclusion
False positives were detected from public, private not for profit and private testing laboratories in almost equal proportion. There is need for standardization of molecular testing platforms in Uganda. There is also urgent need to improve on the Laboratory quality management systems of the molecular testing laboratories in order to minimize such discrepancies.
SUPRAMOLECULAR COMPLEXES OF GLYCYRRHISIC ACID AND ITS MONOAMMONIUM SALT WITH ETHACISIN HYDROCHLORIDE
Authors: Yuldashev Khabibulla Abdurasulevich , Esanov Rakhmat Sulton ugli , Uzbekov Vyacheslav Vadimovich , Saydullaeva Khulkar Tukhtamish kizi , Gafurov Makhmudzhan Bakiyevich , Oshchepkova Yuliya Igorevna , Salikhov Shavkat Ismailovich 
Published: January 2024

The problem of effective and safe therapy of cardiac arrhythmias requires the creation of new antiarrhythmic drugs with low toxicity. Clathration of medicinal substances with cyclodextrins or plant glycosides is a promising method for reducing their side effects and increasing their solubility.
The aim of this research is the complex formation of ethacizin hydrochloride with triterpene glycosides and the study of physicochemical properties of the resulting complexes.
Complexes of glycyrrhizic acid (GA) and its monoammonium salt (MASGA) with ethacizine hydrochloride (EtHQ) in various molar ratios (2 : 1, 4 : 1, 8 : 1) characterized by certain physicochemical parameters have been obtained. The resulting inclusion compounds were studied by UV and IR spectroscopy. It has been determined that molecular complexes of GA and MASGA with EtHQ are formed through weak intermolecular interactions, such as hydrogen bonding, electrostatic and hydrophobic interactions. Supramolecular complexes of natural glycosides with EtHQ have the same stoichiometric composition, approximately equal to the stability constant, and the negative value of the Gibbs free energy confirms the formation of a molecular complex as a result of autoassociation.
The obtained experimental data can serve and/or supplement scientific data for the creation of new promising drugs with a broad therapeutic effect, targeted delivery, synergistic effect and low toxicity.