bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new cybersecurity risk assessment framework for the hospitality industry: techniques and methods for enhanced data protection and threat mitigation
Authors: Pipyros Kosmas , Liasidou Sotiroula 
Published: February 2025

PurposeThe purpose of this research is to emphasize the importance of cybersecurity in the hospitality industry and to propose a particular cybersecurity framework of best practices and techniques to mitigate vulnerabilities and prevent cyberattacks in hotels.Design/methodology/approachExploratory research was conducted through semi-structured interviews with hotel managers. The interview content enables the retrieval of real-case cybersecurity incidents, identifies hotels’ vulnerabilities and suggests a new methodological approach to conduct risk assessment in the hospitality industry to mitigate threats and ensure cybersecurity and data protection.FindingsResearch results show that hotels need to prioritize cybersecurity and limit cyber threats. To achieve this, hotels must develop effective risk assessment methods and mechanisms followed by implementing the necessary technical and organizational measures to mitigate threats and vulnerabilities, prevent malicious cyberattacks and ensure information security.Originality/valueThis research highlights a new methodological approach to perform effective risk assessment in the hospitality industry as well as a framework of cybersecurity methods and techniques to implement effective controls and mitigate cybersecurity risks.
Mining differentially expressed genes in Fagus crenata seedlings in response to short‐term soil drought stress
Authors: Torimaru Takeshi , Ao Hinako , Akaji Yasuaki , Akada Shinji , Ohmiya Yasunori , Matsuda Yosuke , Kisanuki Hiromitsu , Tomaru Nobuhiro 
Published: February 2025

AbstractWe analyzed the transcriptional response of current‐year Fagus crenata (beech) seedling leaves after exposure to short‐term drought. Following well‐watered and water‐stressed treatments, we mapped the RNA‐seq reads from the sampled leaves and identified 127 differentially expressed genes (DEGs), of which 89 were upregulated and 38 downregulated in water‐stressed plants. Several dozen upregulated DEGs were predicted to encode proteins that facilitate mitigating processes or help avoid the adverse effects caused by drought stress, including stomatal closure, reactive oxygen species (ROS) scavenging, abscisic acid (ABA) accumulation and response, and accumulation of osmoprotectants. The functional category of sulfate assimilation was enriched in upregulated DEGs, although there was also evidence of sulfur deficiency. These results suggest the existence of molecular mechanisms in beech that are common to other plant species, representing an acclimation response to drought stress as well as sulfur metabolism under drought stress conditions.
Enhancing Tenebrio molitor Larvae Growth and Nutrition: The Potential of Wheat Bran and Coffee Grounds Blends
Authors: Lee Sung‐Hoon , Choi Sung‐Up 
Published: February 2025

ABSTRACTCoffee grounds, a solid residue left after coffee extraction, are often discarded in landfills or incinerated, posing environmental concerns. To promote sustainability, this study explores the potential use of coffee grounds as a feed source for Tenebrio molitor (TM) larvae. The growth performance, survival rates, and nutritional properties of TM larvae were evaluated using three feed groups: wheat bran, coffee grounds, and a blend of the two. TM larvae (2 g of 3rd instar per group) were randomly assigned to one of three treatments in a completely randomized design: (1) 100 g wheat bran, (2) 100 g of a wheat bran and coffee grounds blend, or (3) 100 g coffee grounds. Results revealed that the blend of wheat bran and coffee grounds yielded the highest growth and survival rates, followed by wheat bran, with coffee grounds alone showing the least favorable outcomes. Nutritional analysis indicated that larvae fed on the blended diet exhibited enhanced crude protein content and reduced crude fat compared to larvae fed on wheat bran or coffee grounds alone. These findings suggest that the blend of wheat bran and coffee grounds serves as a promising feed additive for TM larvae, improving growth, survival, and nutritional quality while supporting the sustainable use of coffee byproducts.
Dynamic changes in microbial communities during sweet flour sauce fermentation and their correlations with physicochemical properties and volatile compounds
Authors: Sang Ziqing , Xie Qiang , Chen Chen , Luo Dan , Xue Wentong 
Published: February 2025

AbstractSweet flour sauce is a traditional fermented condiment in China, known for its distinct sweet and savory flavor profile. During the fermentation process, the dominant bacterial genera were Ralstonia and Bacillus, and the dominant fungal genera were Aspergillus, Issatchenkia, Clavispora, and Zygosaccharomyces. In addition, total acidity (TA) and amino acid nitrogen (AAN) in different fermentation stages were determined by the acidometer titration method, and reducing sugar (RS) was determined by the 3,5‐dinitrosalicylic acid method. The correlation network revealed TA, RS, and AAN were closely related to multiple microorganisms. TA showed significant positive correlations with Gluconobacter, Candida, and Clavispora. RS was positively correlated with Geotrichum, and AAN was positively correlated with Methylobacterium‐Methylorubrum and Zygosaccharomyces. Correlation network analysis was also conducted to show the significant correlations among 2 bacterial genera, 9 fungal genera, and 16 characteristic volatile compounds. In general, the relationships between fungus and volatiles were more significant, with a wide range of yeasts exerting significant functions in forming flavor compounds, whereas most bacteria were negatively correlated with volatiles. Among fungi, Clavispora and Meyerozyma were positively associated with furfural, methional, 5‐methyl‐2‐phenyl‐2‐hexenal, 2‐isopropyl‐5‐methylhex‐2‐enal, and benzeneacetaldehyde. Zygosaccharomyces exhibited strong correlations with acetic acid, 2‐furanmethanol, phenylethyl alcohol, and 2‐methyl‐1‐butanol. These findings can be used to better understand and manage the fermentation process, making it possible to improve the quality of sweet flour sauce by enriching key microorganisms.Practical ApplicationDuring the fermentation of sweet flour sauce, the metabolic activities of microbial communities exerted an important function in forming unique sensory and nutritional properties. These findings revealed significant correlations among microorganisms, vital physicochemical indices, and key volatiles, providing a theoretical foundation for regulating the fermentation process, enhancing product qualities, and developing functional strains.
Effects of temperature on the physicochemical properties and total phenolic content of red and green chilies during postharvest storage
Authors: Mohd Akbar Siti Suhaila , Azmie Nur Aina Atiqah , Mohd Ali Maimunah 
Published: February 2025

AbstractChilies are usually packed and stored after harvesting for sale, which can result in quality loss and affect the edibility of the product. This study aimed to determine the effect of temperature on the physicochemical properties of red and green chilies during postharvest storage at three different temperatures (0, 5, and 25°C). The physicochemical analysis of chilies was conducted for 9 days to determine color changes, texture, pH, total soluble solids, and total phenolic content (TPC). All test data were statistically analyzed using two‐way analysis of variance and Pearson's correlation coefficient to determine the relationship between physicochemical properties and the TPC. The study found that the TPC values decreased significantly at all temperatures for both red and green chilies. At 5°C, the TPC values were 3.42 mg GAE/g extract and 2.23 mg GAE/g extract for red and green chilies, respectively. The red chilies showed the lowest values of texture and TPC at 0°C, indicating poor preservation. The green chilies at 0°C had higher TPC values (4.74 mg GAE/g extract) but suffered from high firmness loss, whereas 25°C led to microbial growth. Therefore, the overall quality and market acceptability of both red and green chilies were ideal at 5°C due to better preservation of physical appearance. In conclusion, the ideal storage condition at 5°C can reduce qualitative and postharvest losses of red and green chilies by maintaining better texture and acceptable TPC values.
Alkaloid profile of Italian alpine milk
Authors: Nardin Tiziana , Piasentier Edi , Romanzin Alberto , Martinelli Francesca , Larcher Roberto 
Published: February 2025

AbstractThis study examines the alkaloid profiles in alpine milk. Alkaloids could pose a health concern but also prove interesting from a geographic traceability perspective. Over three consecutive days, 48 daily milk samples were collected from 16 lactating cows grazing on two alpine pastures in Northeast Italy, with 8 cows from each pasture. Simultaneously, alpine herbs selecting by the cows during grazing were collected using the hand‐plucking technique. Additionally, 12 milk mass samples were obtained from an entire herd of 110 cows. Liquid chromatography coupled with high‐resolution mass spectrometry was employed to analyze both herbage and milk samples, identifying 41 alkaloids with pure standards and putatively identifying another 116. The results revealed a transfer of 0.4% for pyrrolizidine alkaloids, 2.7% for indole alkaloids, and 12% for steroidal alkaloids from herbs to milk. A partial least squares—discriminant analysis model based on the alkaloid profiles achieved a correct reclassification of 67% of milk samples from cows grazing on the two distinct pastures. Despite the minimal transfer, which should be considered positive in terms of health, it opens the door to interesting studies on the use of alkaloids as traceability markers for mountain products.Practical ApplicationThe study provides a novel perspective interaction between alpine grazing systems and milk composition. This research could be useful for enhancing mountain pasture products in terms of healthiness and can help prevent fraud on the declaration of origin.
High‐intensity ultrasound‐assisted extraction for functionalized pistachio meal protein concentrate
Authors: Yildiz Semanur , Karabulut Gulsah , Sıçramaz Hatice 
Published: February 2025

AbstractThe residues left over from cold‐pressing oilseeds and fruits offer a promising source of plant proteins, serving as an alternative resource within the circular economy framework. This research aims to develop protein concentrates (PCs) from pistachio meal with enhanced functional properties using ultrasound ‐assisted extraction (UAE). A response surface methodology was employed to optimize UAE considering power (200–600 W), time (5–25 min), and pH (8–11). Through a Box–Behnken experimental design, the optimal extraction conditions were determined as 595 W, pH 11, and 19 min, targeting maximal protein extraction yield (R2: 0.9359, desirability of 0.993). Under these ideal conditions, UAE achieved higher protein extraction yield (51%), compared to the conventional alkaline extraction (AE) (39%). Protein recovery rate increased from 33.1% to 44% by UAE. PCs obtained through the AE (PC‐AE) and optimal UAE (PC‐UAE) were evaluated for their functional, structural, and morphological properties. UAE significantly improved the emulsion activity index of the PC‐UAE by 34.9% (p < 0.05), whereas solubility and foaming activity showed slight increases compared to PC‐AE (p > 0.05). US‐induced size reduction as observed by smaller and irregular particles in morphological analysis. The Fourier‐transform infrared spectroscopy spectra, analyzed using a curve‐fitting approach on the second derivative, revealed hidden peaks that highlighted changes in the secondary structure of the PCs, including slight shifts in characteristic wavenumbers and variations in the proportional amounts of β‐sheet, α‐helix, and random coil structures. This study demonstrated that UAE achieved similar protein purity as AE while producing larger quantities through higher recovery of proteins with improved functional properties.Practical ApplicationUltrasound‐assisted alkaline extraction significantly boosts protein extraction yield and recovery from pistachio meal and enhances functional properties (especially emulsion activity) of the extracted proteins. These improvements make the UAE protein concentrates suitable for applications in food formulations, such as plant‐based beverages and emulsified products. UAE offers a sustainable approach to valorize oilseed residues in the context of circular economy.
Laminaria japonica polysaccharide protects against liver and kidney injury in diabetes mellitus through the AhR/CD36 pathway
Authors: Xue Tao , Chen Xiaoxue , Wang Jiacai , Zhang Bo , Sun Yanlei , Xin Jie , Shao Fengli , Li Xinpeng 
Published: February 2025

AbstractThe lipid accumulation associated with diabetes causes continuous liver and kidney damage. Laminaria japonica polysaccharide (fucoidan) has been shown to regulate the disorder in lipid metabolism caused by diabetes. Herein, we established a diabetes mellitus (DM) rat model through a high‐fat and high‐sugar diet combined with streptozotocin. An automatic biochemical analyzer was used to detect serum lipid content, and hematoxylin and eosin, Masson, periodic acid‐silver‐methenamine, and Oil Red O staining were used to observe changes in the structure of the kidney and liver, including fibrosis and lipid accumulation. We confirmed that fucoidan could ameliorate renal injury, lipid metabolism, and oxidative stress in streptozotocin‐induced diabetic rat models. Metabolomics analysis demonstrated that amino acid metabolism is an important process. We further demonstrated a novel role of fucoidan in regulating kidney and liver lipid metabolism through the aryl hydrocarbon receptor (AhR)‐mediated CD36 signaling pathway. Similar results were found in DM rats treated with an AhR inhibitor, as well as in those treated with a combination of both an AhR inhibitor and fucoidan. Importantly, we observed a higher expression of AhR/CD36 in the kidneys and liver of rats with DM, and the level of AhR/CD36 correlated with lipid accumulation and kidney function, suggesting that AhR/CD36 signaling could be a promising therapeutic target for fucoidan in treating lipid metabolism in DM.Practical ApplicationAs the main component of Laminaria japonica, fucoidan has excellent antioxidant properties and protective effects against liver and kidney damage in diabetes mellitus. It can play a protective role in the daily diet of diabetic patients. Alternatively, it could be developed as a potential therapeutic drug for the treatment of diabetes.
The Impact of Immune‐Related Adverse Event Severity on Prognosis in Elderly Patients With Nonsmall‐Cell Lung Cancer in First‐Line Immune Checkpoint Inhibitor Treatment
Authors: Miyamoto Ippei , Shimizu Tetsuo , Hanamura Mizuki , Mizuno Yu , Nakayama Ryota , Kusahana Ryo , Nomoto Masayuki , Nakagawa Yoshiko , Gon Yasuhiro 
Published: February 2025

ABSTRACTBackgroundRecently, the treatment needs of elderly lung cancer patients have become comparable with those of younger patients. This study evaluated the efficacy and safety of first‐line immune checkpoint inhibitors (ICI) in elderly patients with nonsmall‐cell lung cancer (NSCLC), stratified by immune‐related adverse events (irAEs) severity, and identified key prognostic factors.MethodsThis retrospective study targeted patients with advanced or recurrent NSCLC who received ICI therapy as first‐line treatment between April 2017 and March 2023.ResultOf the 138 patients enrolled in this study, 81 and 57 patients were classified into the elderly (aged 70 and above) and nonelderly (under 70 years old) groups, respectively. Severe irAEs were significantly associated with shorter overall survival (OS) in the elderly group (severe irAEs vs. others, 9.9 vs. 24.7 months; p = 0.043) and favorable OS in nonelderly group (severe irAEs vs. others, NR [not reached] vs. 21.0 months, p = 0.026). The OS of patients with severe irAEs was significantly worse in the elderly group than in the nonelderly group (elderly group vs. nonelderly group, 9.9 vs. NR months, p = 0.001). In the multivariate analysis, mild irAEs were associated with a favorable prognosis in elderly patients (hazard ratio, 0.446; p = 0.032).ConclusionSevere irAEs demonstrated different outcomes in elderly and nonelderly patients. Contrastingly, mild irAEs were associated with a favorable prognosis in elderly patients, emphasizing the need for appropriate patient selection, early intervention for irAEs and new tools to accurately predict irAE severity in elderly patients.
Stage IIIA Non‐Small Cell Lung Cancer Treatment and Outcomes: A Single Institution Retrospective Analysis
Authors: Duan Richard , Kwan Michelle , Kordon Avram , Hu Carolyn J. , Vanjani Nisheka , Liu Yingzhe , Thomas Tarita O. , Gupta Divya , Patel Jyoti , Yadav Poonam , Abazeed Mohamed E. , Sun Zequn , Gharzai Laila A. 
Published: February 2025

ABSTRACTObjectivesStage III non‐small cell lung cancer (NSCLC) treatment remains challenging, with a multitude of treatment options available. We assessed Stage IIIA NSCLC outcomes by treatment received.MethodsWe performed a single‐institution retrospective review of NSCLC patients with Stage IIIA disease treated January 01, 2010—March 01, 2022. Demographics, treatments, outcomes, and failure patterns were collected. Progression‐free survival (PFS) and overall survival (OS) were assessed using Kaplan–Meier analysis. Failure patterns were assessed for differences using chi‐square analysis.ResultsOf 270 Stage III NSCLC patients, 134 had Stage IIIA disease with a median follow‐up of 29.9 months and a median age of 66 years (IQR 60–75). 66 (49.3%) patients were male, and 105 (78.4%) were current/former smokers (with 30 median pack‐years). Patients were treated with definitive radiation with/without chemotherapy (CRT; n = 77, 57.5%), surgery with neoadjuvant chemotherapy and/or radiation (Neoadj; n = 42, 31.3%), and surgery without neoadjuvant therapy (Surg; n = 15, 11.2%). Median PFS was 25.4 months (95% CI 12.5–42.6) for CRT, 22.6 months (95% CI 12.2–44.4) for Neoadj, and 22.8 months (95% CI 5.2‐NA) for Surg with no significant intergroup difference (p = 0.99). Median OS was 57.0 months (95% CI 37.4–77.5) for CRT, 51.5 months (95% CI 36.7–65.5) for Neoadj, and 35.3 months (95% CI 16.8‐NR) for Surg with no significant intergroup difference (p = 0.99).ConclusionsIn this single institution retrospective study, we find no significant differences in PFS, OS, and failure patterns between patients with Stage IIIA NSCLC treated with definitive (chemo)radiation and surgery with or without neoadjuvant therapy. Further work in the immunotherapy era is needed.
Hospitalize or discharge the emergency department patient with syncope? A systematic review and meta‐analysis of direct evidence for SAEM GRACE
Authors: Allen Robert , deSouza Ian S. , Wakai Abel , Richards Rebekah , Ardilouze Amelie , Dunne Eric , Rovic Isidora , Benabbas Roshanak , Zehtabchi Shariar , Sinert Richard 
Published: February 2025

AbstractBackgroundSyncope is a frequent reason for hospitalization from the emergency department (ED), but the benefit of hospitalization is unclear. This systematic review and meta‐analysis (SRMA) aims to cohere and synthesize the best current evidence regarding the potential benefit of hospitalization for ED syncope patients for developing an evidence‐based ED syncope management guideline.MethodsWe conducted a SRMA according to the patient–intervention–control–outcome (PICO) framework: In patients 16 years of age or older who present to the ED with syncope (population), does hospitalization (intervention) or direct ED discharge (comparison) improve short‐term outcomes (outcome)? The primary outcome was a composite of all adverse events as defined by individual studies, up to 30 days. Two reviewers independently assessed articles for inclusion and methodological quality. We measured heterogeneity among included studies with I‐squared statistic and used GRADE criteria to assess the quality of evidence.ResultsOur search strategy identified 2140 publications and included 18 publications (510,545 participants) in the analysis. All studies reported higher rates of adverse events in hospitalized patients (0.7%–43.8%) compared to discharged patients (0%–3.7%). Our meta‐analysis detected considerable statistical heterogeneity. The GRADE assessment for all adverse events and all‐cause mortality revealed risk ratios of >5 favoring ED discharge for both outcomes at a median follow‐up of 30 days. However, point estimates are limited by serious risk of bias, inconsistency, imprecision, indirectness, and publication bias.ConclusionsDue to the uncertainty of the available evidence, this SRMA's findings do not support a recommendation for or against hospitalizing patients presenting to ED with syncope. However, discharging low‐risk patients with syncope from the ED is associated with a low risk of short‐term adverse events.
Circular and spherical projected Cauchy distributions: A novel framework for directional data modelling
Authors: Tsagris M. , Alzeley O. 
Published: February 2025

SummaryWe introduce a novel family of projected distributions on the circle and the sphere, called the circular and spherical projected Cauchy distributions, as promising alternatives for modelling circular and spherical data. The circular distribution encompasses the wrapped Cauchy distribution as a special case while featuring a more convenient parameterisation. We also propose a generalised wrapped Cauchy distribution that includes an extra parameter, enhancing the fit of the distribution. In the spherical context, we impose two conditions on the scatter matrix of the Cauchy distribution, resulting in an elliptically symmetric distribution. Our projected distributions exhibit attractive properties such as a closed‐form normalising constant and straightforward random value generation. The distribution parameters can be estimated using maximum likelihood, and we assess their bias through numerical studies. Further, we compare our proposed distributions with existing models with real datasets, demonstrating equal or superior fitting both with and without covariates.
Can teacher ostracism be prevented? Exploring how empowering leadership can mitigate teacher ostracism through work engagement
Authors: Uslukaya Alper 
Published: February 2025

AbstractAimUsing the job demands‐resources model, this study theorizes the negative longitudinal relationship between empowering leadership and teacher ostracism, both directly and through work engagement.MethodFor this purpose, data collected in three waves at four‐month intervals from 473 teachers (51.6% women; mean age = 42.26) working in schools at different levels in the centre of Elazığ province, eastern Turkey, during the 2022–2023 academic year were used. The relationships between the variables were analysed using a cross‐lagged panel model with latent variables.ResultsThe findings showed that empowering leadership positively related to work engagement and negatively related to teacher ostracism. Work engagement, in turn, is negatively related to teacher ostracism. Additionally, empowering leadership was found to be negatively related to teacher ostracism through work engagement.ConclusionThese results suggest that empowering leadership may be a crucial factor in preventing teacher ostracism, both directly and by enhancing employee engagement. The article concludes by discussing the theoretical contributions of the findings and presenting practical implications to help mitigate the risk of teacher ostracism.