bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Influence of Gut Microbiota-related Metabolites in
Gastrointestinal Cancer
Authors: Marzhoseyni Zeynab , Shaghaghi Zahra , Alvandi Maryam , Shirvani Maria 
Published: January 2024

Abstract:
Gastrointestinal (GI) cancer is a major health concern due to its prevalence, impact on
well-being, high mortality rate, economic burden, and potential for prevention and early detection.
GI cancer research has made remarkable strides in understanding biology, risk factors, and treatment
options. An emerging area of research is the gut microbiome's role in GI cancer development
and treatment response. The gut microbiome, vital for digestion, metabolism, and immune
function, is increasingly linked to GI cancers. Dysbiosis and alterations in gut microbe composition
may contribute to cancer development. Scientists study how specific bacteria or microbial
metabolites influence cancer progression and treatment response. Modulating the gut microbiota
shows promise in enhancing treatment efficacy and preventing GI cancers. Gut microbiota dysbiosis
can impact GI cancer through inflammation, metabolite production, genotoxicity, and immune
modulation. Microbes produce metabolites like short-chain fatty acids, bile acids, and secondary
metabolites. These affect host cells, influencing processes like cell proliferation, apoptosis, DNA
damage, and immune regulation, all implicated in cancer development. This review explores the
latest research on gut microbiota metabolites and their molecular mechanisms in GI cancers. The
hope is that this attempt will help in conducting other relevant research to unravel the precise
mechanism involved, identify microbial signatures associated with GI cancer, and develop targets.
Synthesis of Some Novel 4-bromobenzoic Acid Clubbed Hydrazone Schiff Base Derivatives as Potent α-amylase Inhibitors: In vitro and In silico Studies
Authors: Khan Momin , Alam Faima , Alam Aftab , Wadood Abdul , Shams Sulaiman , Ali Mahboob , Shah Sana , AlAsmari Abdullah F. , Alharbi Metab , Alasmari Fawaz 
Published: January 2024

Aims:
Synthesis of novel 4-bromobenzoic acid-based hydrazone-Schiff base derivatives
and to screen them for their α-amylase inhibitory activity.

Objective:
The biological activities of hydrazone-Schiff base compounds encouraged us to evaluate
the synthesized derivatives (4-32) for in-vitro inhibition activity against the α-amylase enzyme.

Methods:
In current research work twenty-nine Schiff base derivatives (4-32) of 4-bromobenzoic
acid were synthesized in worthy yields by treating various replaced aldehydes with 4-
bromobenzohydrazide using methanol solvent in catalytic quantity of acetic acid. The products
were structurally described through the support of several spectroscopic methods (EI-MS and 1HNMR)
and finally evaluated against α-amylase enzyme.

Results:
All the made derivatives exhibited worthy inhibition potential from IC50 = 0.21 ± 0.01 to
5.50 ± 0.01 μM when equated to the usual acarbose drug having IC50 = 1.34 ± 0.01 μM. Compound
21 (IC50 = 0.21 ± 0.01 μM) was established as the most active inhibitor among the series
better than standard. The structure-activity relationship study showed that the alteration in the activity
of the produced products might be due to the attached position and nature of the substituents.
Furthermore, in-silico study supported the effects of groups attached on the binding interaction
with α-amylase enzyme.

Conclusion:
A series of substituted hydrazone Schiff bases based on 4-bromobenzoic acid were
produced, confirmed the structures by EI-MS and 1H-NMR spectroscopic methods and lastly tested
for their in-vitro α-amylase inhibitory potential. Among the series, twenty-four products indicated
brilliant inhibition potential having IC50 values from 0.21 ± 0.01 to 1.30 ± 0.01 μM. The
structure-activity relationship study showed that the alteration in the activity of the synthesized
products might be due to the attached position and nature of the substituents. On the other hand, in
silico studies advocated that the synthesized Schiff base derivatives have prevalent interactions of
binding within the active site of the α-amylase enzyme, and because of their various attached substituent,
their conformation is altered in the active site of the enzyme. The current study recognized
a number of lead candidates derived from 4-bromobenzoic acid. Additional investigation of the
synthesized derivatives for coming research to get novel α-amylase inhibitors.
Is there an Association between Complementary and Alternative Medicine
use and Trust in Physicians in Patients with Rheumatic Diseases?
Authors: Aharrane Fatima Zahra , Taik Fatima Zahrae , Takhrifa Nihad , Bensaid Rajaa , Soba Nabil , Fourtassi Maryam , Abourazzak Fatima Ezzahra 
Published: January 2024

Introduction:
Generally, patients with chronic rheumatic diseases use complementary
and alternative medicine (CAM) in addition to their conventional treatments to manage their
health. Discussing these treatments with their physician is still rare, which might be directly related
to patients’ trust toward them.

Aim:
The primary objective of this study was to assess the association between patients’ trust in
their physician and the use of complementary and alternative medicine among patients with chronic
inflammatory rheumatic diseases. As secondary objectives, to estimate the prevalence of CAM
use, and to identify the associated factors with their use and with trust in physicians.

Methods:
This is a cross-sectional study, which included patients with established chronic inflammatory
rheumatic diseases, at the University Hospital Center in Tangier. The questionnaire included
demographic and clinical information, use of conventional therapy, complementary and alternative
therapy, as well as interpersonal trust in patient-physician relationships using the Trust in
Physician Scale (TPS). A regression analysis was conducted to identify factors associated with
CAM use and with trust in physicians.

Results:
The study included 189 patients. 57.14% of patients reported using complementary
medicine at least once, most patients were women (77.78%), mean age was 46.67 ± 13.25 years
with an average course of the disease of 11.11 ± 9.23 years. The most frequently used CAM treatments
were cupping therapy, massage and the ingestion of a mixture of plants. Mean ± SD Trust
in Physician Scale was 47.64 ± 7.2. There was no significant difference between CAM users vs.
non-users (48.08 ± 6.9 vs 47.04 ± 7.4; p = 0.35). In uni and multivariate analysis, a low level of education
was significantly associated with the use of CAM. However, no statistically significant difference
was found with trust in physicians (OR = 1.020, 95% CI (0.978-1.063), p = 0.354).

Conclusion:
CAM therapy is common in patients with chronic inflammatory rheumatic diseases.
No statistically significant association was found with trust in physicians, it was rather observed
with level of education.
Intrathecal Baclofen Infusion-Botulinum Toxin Combined Treatment
Efficacy in the Management of Spasticity due to Cerebral Palsy
Authors: Marvulli Riccardo , Lagioia Giuseppa , Ianieri Giancarlo , Dell'Olio Lucrezia , Zonno Alessandra , Riccardi Mariagrazia , Sinisi Rosa Bianca , Rizzo Laura Belinda , Farì Giacomo , Megna Marisa , Ranieri Maurizio 
Published: January 2024

Background:
Cerebral Palsy (CP) is a group of permanent, but not unchanging, disorders
of movement and/or posture and motor function, which are due to a non-progressive interference, lesion,
or abnormality of the developing/immature brain. One clinical presentation is muscle spasticity,
which leads to a significant impact on the individual’s functionality and quality of life. Spasticity
treatment is multidisciplinary and includes pharmacological and physical intervention; intrathecal
baclofen shows a positive effect in severe spasticity and suboptimal response to oral drugs, while local
injection of Botulinum toxin type A (BTXA) improves muscle tone, motion and pain.

Objective:
The aim of this study was to evaluate the efficacy of the combined intrathecal baclofen
infusion (ITB) - botulinum toxin treatment in the management of spasticity in CP.

Methods:
8 patients with spastic tetraparesis were enrolled. All patients were treated with intrathecal
Baclofen; in lower limbs, no spastic symptoms appeared, while marked spasticity was noted in upper
limbs. We injected the right and left Biceps Brachial (BB) and Flexor Digitorum Superficialis (FDS)
muscles with botulinum toxin type A. All patients underwent Myometric measurement, Ashworth
Scale, Numerical Rating Scale, and Visual Analogic Scale evaluation before infiltration (T0), 30
days after injection (T1), 60 days after injection (T2), and 90 days after treatment (T3).

Results:
All data demonstrated an improvement in spasticity, pain, quality of life, and self-care during
the study, with p < 0.05. No side effects appeared.

Conclusion:
This study demonstrated the efficacy and safety of intrathecal baclofen infusion and
botulinum toxin combined treatment in the management of spasticity, pain, quality of life, and selfcare
in CP patients.
Nanostructured Lipid Carrier-loaded In Situ Gel for Ophthalmic Drug Delivery: Preparation and In Vitro Characterization Studies
Authors: Sabale Vidya , Belokar Vaishnavi , Jiwankar Manasi , Sabale Prafulla 
Published: January 2024

Background:
Nanostructured lipid carriers (NLCs) are explored as vehicles for ophthalmic
drug delivery owing to their better drug loading, good permeation, and satisfactory safety profile.

Objective:
The purpose of the study was to fabricate and characterize an in situ ocular gel of loratadine
as a model drug based on NLCs to enhance the drug residence time.

Methods:
NLCs were fabricated using the microemulsion method in which solid lipid as Compritol
888 ATO, lipid as oleic acid, surfactant as Tween 80, and isopropyl alcohol as co-surfactant as alcohol
were used. Based on the evaluation of formulation batches of NLCs, the optimized batch was selected
and further utilized for the formulation of in situ gel containing Carbopol 934 and HPMC
K15M as gelling agents, and characterized.

Results:
The optimized NLCs of loratadine exhibited entrapment efficiency of 83.13 ± 0.13% and an
average particle size of 18.98 ± 1.22 nm. Drug content and drug release were found to be 98.67 and
92.48%, respectively. Excellent rheology and mucoadhesion were demonstrated by the loratadine
NLC-loaded in situ gel to enhance its attachment to the mucosa. NLC-based in situ ocular gel showed
the desired results for topical administration. The prepared gel was observed to be non-irritating to
the eye.

Conclusion:
The optimized NLC-based in situ gel formulation presented better corneal retention and
it was found to be stable, offering sustained release of the drug. Thus, the joined system of sol-gel
was found promising for ophthalmic drug delivery.
Assessing EFL Papuan students’ ability in memorizing English vocabulary using context clues strategy
Authors: Gultom Monika 
Published: January 2024

Research on how to utilize students’ ability to master the foreign language especially in memorizing some words in a target language is believed very important. The purpose of the study is to assess the ability of native Papuans in memorizing some English vocabulary using the keyword system strategy of a selected translated Sentani folktale, entitled The Legend of Sentani Lake. Data was obtained from around 32 students who were asked to memorize several target words. The result showed that students’ keyword system strategy was useful in connecting the spelling, pronunciation, and new words to their prior knowledge by looking at the similarity between the target word and keyword in sound using the key-word system strategy. It is also showed that Papuan EFL students have a high ability to utilize existing knowledge and memorable relationship to memorize new or currently studied English vocabulary. The findings provide important insight for foreign language teaching and learning regarding the importance of encouraging students to develop their ability to master the language being learned by connecting it with something close to the context of Papuan native students’ live in order to make it more effective and meaningful.
Privacy Concerns About Sharing General and Specific Health Information on Twitter: Quantitative Study
Authors: Esmaeilzadeh Pouyan 
Published: January 2024

Background
Twitter is a common platform for people to share opinions, discuss health-related topics, and engage in conversations with a wide audience. Twitter users frequently share health information related to chronic diseases, mental health, and general wellness topics. However, sharing health information on Twitter raises privacy concerns as it involves sharing personal and sensitive data on a web-based platform.

Objective
This study aims to adopt an interactive approach and develop a model consisting of privacy concerns related to web-based vendors and web-based peers. The research model integrates the 4 dimensions of concern for information privacy that express concerns related to the practices of companies and the 4 dimensions of peer privacy concern that reflect concerns related to web-based interactions with peers. This study examined how this interaction may affect individuals’ information-sharing behavior on Twitter.

Methods
Data were collected from 329 Twitter users in the United States using a web-based survey.

Results
Results suggest that privacy concerns related to company practices might not significantly influence the sharing of general health information, such as details about hospitals and medications. However, privacy concerns related to companies and third parties can negatively shape the disclosure of specific health information, such as personal medical issues (β=−.43; P<.001). Findings show that peer-related privacy concerns significantly predict sharing patterns associated with general (β=−.38; P<.001) and specific health information (β=−.72; P<.001). In addition, results suggest that people may disclose more general health information than specific health information owing to peer-related privacy concerns (t165=4.72; P<.001). The model explains 41% of the variance in general health information disclosure and 67% in specific health information sharing on Twitter.

Conclusions
The results can contribute to privacy research and propose some practical implications. The findings provide insights for developers, policy makers, and health communication professionals about mitigating privacy concerns in web-based health information sharing. It particularly underlines the importance of addressing peer-related privacy concerns. The study underscores the need to build a secure and trustworthy web-based environment, emphasizing the significance of peer interactions and highlighting the need for improved regulations, clear data handling policies, and users’ control over their own data.
Web-Based Health Information Seeking by People Living With Multiple Sclerosis: Qualitative Investigation of the Multiple Sclerosis Online Course
Authors: Bevens William , Davenport Rebekah , Neate Sandra , Yu Maggie , Jelinek Pia , Jelinek George Alexander , Reece Jeanette 
Published: January 2024

Background
Digital technologies have afforded people living with multiple sclerosis (MS) access to telehealth consultations, diagnostic tools, and monitoring. Although health care professionals remain the most trusted source of information, the internet has emerged as a valuable resource for providing MS-related information, particularly during the COVID-19 pandemic. Notably, people living with MS are increasingly seeking educational content for a range of topics related to the self-management of MS; however, web-based information seeking remains largely underevaluated. To address this gap and ensure that web-based health-related information is accessible and engaging, this study used qualitative methods to analyze the reflections from participants of web-based educational programs for people living with MS.

Objective
This study aimed to explore the motivations, behaviors, and expectations of web-based health information seeking for people living with MS.

Methods
We conducted semistructured interviews for 38 people living with MS 1 month after they completed the novel MS Online Course, which provided information on modifiable lifestyle-related risk factors for people living with MS. Of the 38 participants, 22 (58%) completed the intervention course and 16 (42%) completed the standard care course. Inductive thematic analysis was used within a qualitative paradigm, and 2 authors coded each interview separately and arrived at themes with consensus.

Results
We identified 2 themes: motivation to learn and MS information on the web. The diagnosis of MS was described as a pivotal moment for precipitating web-based information seeking. People living with MS sought lifestyle-related information to facilitate self-management and increase control of their MS. Although social media sites and MS websites were considered useful for providing both support and information, discretion was needed to critically appraise information. Recognizable institutions were frequently accessed because of their trustworthiness.

Conclusions
This study provided novel insights into the motivations of people living with MS for seeking web-based health information. Furthermore, their preferences for the content and format of the web-based information accessed and their experiences and reactions to this information were explored. These findings may guide educators, researchers, and clinicians involved in MS care to optimize the engagement and processing of web-based health information seeking by people living with MS.
Evaluating the Commensurate with Income Standard
Authors: Sansing Richard C. 
Published: January 2024

ABSTRACT
This study analyzes a model in which intellectual property (IP) that generates uncertain future cash flows is sold by a U.S. parent to a foreign subsidiary. The parent has private, imperfect information regarding the value of the IP. The study compares the firm’s expected tax and penalty payments under the commensurate with income (CWI) standard to the payments under the fair value method, in which the transfer price is the expected value of the IP using all the facts publicly available after the value is realized. It compares payments under both methods to the payments using the fair private price, which is the value of the IP on the date of sale given the parent’s private information. Expected tax and penalty payments using the fair private price are strictly less than expected payments under the CWI standard and are strictly greater than expected payments under the fair value method.
JEL Classifications: H25; H26; H32.
How Do Online Conflict Disclosures Support Enforcement? Evidence from Personal Financial Disclosures and Public Corruption
Authors: Scherf Alexandra A. 
Published: January 2024

ABSTRACT
Public corruption is a concern for democracies around the world. In the U.S., states have responded to this issue by publishing personal financial disclosures (PFDs) for public officials online. PFDs are a conflict-of-interest disclosure designed to relieve agency conflicts between private citizens and government officials by documenting overlaps between officials’ financial interests and public responsibilities. This paper explores whether and how online PFD supports anticorruption enforcement. I present a stylized model illustrating how online PFD leads investigators to increase case referral volume and quality. Empirically, I find that online PFD for local officials is associated with increased referral rates and greater likelihoods of prosecution conditional on referral. I conduct 126 field interviews of federal prosecutors, journalists, and ethics commissions to understand the mechanisms behind these results. I conclude that online PFD supports the enforcement of local corruption by reducing disclosure acquisition costs for enforcement agents.
Screening of Rice Genotypes for Bacterial Blight of Rice Under Artificial Inoculation Method and Monitoring Field Virulence of Xanthomonas oryzae pv. oryzae
Authors: Srinivas Bhukya , Patil V. A. , Shinde C. U. , John Priya , Garde Y. A. , Waghunde R. R. 
Published: January 2024

The present study was conducted at the main rice research centre, Navsari Agricultural University, Navsari, Gujarat, India during kharif (July–November, 2020) to study the screening of rice genotypes for bacterial blight of rice under artificial inoculation method and monitoring field virulence of Xanthomonas oryzae pv. oryzae. Thirty genotypes along with two susceptible checks against bacterial blight pathogen under artificial inoculation condition revealed that, 3 genotypes were found moderately resistant viz., NVSR-466, NVSR-396 and ISM. Whereas, 12 genotypes viz., NVSR-411, NVSR-443, NVSR-447, NVSR-453, GNR-6, IR-28, NAUR-1, GNR-2, Gurjari, GNR-4, Krishna kamod and GAR-13 were found susceptible to Xoo and two checks viz., GR-11 and TN-1 were found highly susceptible. Observing to the disease severity, by screening 29 IRBB differentials and two checks employed for research on monitoring virulence of Xoo. Out of 29 differentials, 3 entries were found resistant viz., IRBB-53, IRBB-57 and IRBB-60. Whereas, 3 entries viz., IRBB-50, IRBB-52 and IRBB-61 were moderately susceptible reaction and all the single genes possessing entries were found susceptible to Navsari isolates of Xoo. The goal of this study provided valuable insights to determine the potential management strategies for the disease in rice crops by employing methodology of two rows of 2 meters in length for each entry, the susceptible check TN-1 and GR-11 were planted after the 10th test entry for screening of rice genotypes and monitoring the field virulence of Xoo.
Analisis Miskonsepsi Peserta didik Sekolah Dasar tentang Materi Pecahan
Authors: Ariyani Siti Nur 
Published: January 2024

Penelitian ini dilakukan dengan tujuan untuk mengetahui pengetahuan dan pemahaman Guru Sekolah Dasar pada miskonsepsi yang dialami peserta didik sekolah dasar tentang mata pelajaran matematika materi pecahan. Metode penelitian kualitatif studi kasus digunakan untuk melakukan penelitian. Data dikumpulkan dengan bentuk semi terstruktur yang dikembangkan oleh peneliti untuk mengumpulkan pandangan Guru Sekolah Dasar tentang miskonsepsi peserta didik. Para guru menyatakan bahwa pada materi pecahan, peserta didik sekolah dasar paling banyak mengalami kesulitan cara merepresentasikan bentuk-bentuk pecahan, konsep penyebut dan pembilangnya, cara mengurutkan pecahan dari terkecil atau dari terbesar, menyelesaikan soal cerita, membaca dan menulis pecahan, membandingkan pecahan dan mengubah pecahan ke dalam bentuk yang berbeda, menunjukkan nilai pecahan garis bilangan dan peserta didik memiliki kesalahpahaman tentang operasi hitung penjumlahan dan pengurangan pecahan.
Theoretical aspects of the organization of the management decision–making process at the enterprise
Authors: Bogomolov D. V. 
Published: January 2024

At the present stage of economic development of Russian entrepreneurship, the most important task is the formation of directions for making competent and timely management decisions for further improvement of the management of financial, economic and organizational activities of organizations and the development of competitive advantages in the market.The constantly occurring changes in the socio-economic relations of the country, taking into account the policy of the state, the dynamics in consumer demand and market conditions, require economic entities to create an adequate enterprise management system based on managerial decision-making. The decisions themselves, of course, are the result of financial analysis, balanced conclusions and action plans, since they are designed to optimize various aspects of the activities of economic entities.