bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipophilic arsenic compounds in the cultured green alga Chlamydomonas reinhardtii
Authors: Raab Andrea , Zhang Jinyu , Ge Ying , Fernández-Mendoza Fernando , Feldmann Jörg 
Published: January 2024

AbstractIn this study, arsenic (As) speciation was investigated in the freshwater alga Chlamydomonas reinhardtii treated with 20 μg/L arsenate using fractionation as well as ICP-MS/ESI-MS analyses and was compared with the known As metabolite profile of wild-grown Saccharina latissima. While the total As accumulation in C. reinhardtii was about 85% lower than in S. latissima, the relative percentage of arsenolipids was significantly higher in C. reinhardtii (57.0% vs. 5.01%). As-containing hydrocarbons and phospholipids dominated the hydrophobic As profile in S. latissima, but no As-containing hydrocarbons were detectable in C. reinhardtii. Instead for the first time, an arsenoriboside-containing phytol (AsSugPhytol) was found to dominate the hydrophobic arsenicals of C. reinhardtii. Interestingly, this compound and its relatives had so far been only found in green marine microalgae, open sea plankton (mixed assemblage), and sediments but not in brown or red macroalgae. This compound family might therefore relate to differences in the arsenic metabolism between the algae phyla.
Better stoma care using the Stoma App: does it help? A first randomized double-blind clinical trial on the effect of mobile healthcare on quality of life in stoma patients
Authors: van der Storm Sebastiaan L. , Consten Esther C. J. , Govaert Marc J. P. M. , Tuynman Jurriaan B. , Oosterling Steven J. , Grotenhuis Brechtje A. , Smits Anke B. , Marsman Hendrik A. , van Rossem Charles C. , van Duyn Eino B. , de Nes Lindsey C. F. , Verdaasdonk Emiel , de Vries Reilingh Tammo S. , Vening Wouter , Bemelman Willem A. , Schijven Marlies P. ,   the Stoma APPtimize collaborative study group, Boerman Liesbeth W. E. , van den Broek Noor E. , Botman Ivonne J. C. M. , Verhoeven Danielle , Baars Valeria , van Tienderen Claudia , van Bottenberg Patricia , Hartog Judith , Buskens Christianne J. , Hompes Roel , Kusters Miranda , Walma Marieke S. , Meijs Bono 
Published: January 2024

Abstract
Background
Receiving a stoma significantly impacts patients’ quality of life. Coping with this new situation can be difficult, which may result in a variety of physical and psychosocial problems. It is essential to provide adequate guidance to help patients cope with their stoma, as this positively influences self-efficacy in return. Higher self-efficacy reduces psychosocial problems increasing patient’s quality of life. This study investigates whether a new mobile application, the Stoma App, improves quality of life. And if personalized guidance, timed support, and peer contact offered as an in-app surplus makes a difference.

Methods
A double-blind, randomized controlled trial was conducted between March 2021 and April 2023. Patients aged > 18 years undergoing ileostomy or colostomy surgery, in possession of a compatible smartphone were included. The intervention group received the full version of the app containing personalized and time guidance, peer support, and generic (non-personalized) stoma-related information. The control group received a restricted version with only generic information. Primary outcome was stoma quality of life. Secondary outcomes included psychological adaption, complications, re-admittance, reoperations, and length of hospital stay.

Results
The intervention version of the app was used by 96 patients and the control version by 112 patients. After correction for confounding, the intervention group reported a significant 3.1-point improvement in stoma-related quality of life one month postoperatively (p = 0.038). On secondary outcomes, no significant improvements could be retrieved of the intervention group.

Conclusion
The Stoma App improves the quality of life of stoma patients. Peer support and personalized guidance are of significant importance in building self-efficacy. It is to be recommended to implement Stoma app—freely available software qualifying as a medical device—in standard stoma care pathways for the benefits of both patients and healthcare providers.
Frontend and backend electronics achieving flexibility and scalability for tomographic tactile sensing
Authors: Sánchez-Delgado Alberto , Garg Keshav , Scherjon Cor , Lee Hyosang 
Published: January 2024

AbstractTactile sensing is essential for robots to adequately interact with the physical world, but creating tactile sensors for the robot’s soft and flexible body surface has been a challenge. The resistance tomography-based tactile sensors have been introduced as a promising approach to creating soft tactile skins because the sensor fabrication can be greatly simplified with the aid of a computation model. This article introduces an electronic design strategy dividing frontend and backend electronics for the resistance tomography-based tactile sensors. In this scheme, the frontend is made of the piezoresistive structure and electrodes that can be changed depending on the required geometry. The backend is the electronic circuit for resistance tomography, which can be used for various frontend geometries. To evaluate the use of a unified backend for different frontend geometries, two frontend specimens with a square shape and a circular shape are tested. The minimum detectable contact force and the minimum discernible contact distance are calculated as $$0.83 \times 10^{-4}$$

0.83
×

10

-
4

N/mm$$^2$$

2

, 2.51 mm for the square-shaped frontend and $$1.19 \times 10^{-4}$$

1.19
×

10

-
4

N/mm$$^2$$

2

, 3.42 mm for the circular-shaped frontend. The results indicated that the proposed electronic design strategy can be used to create tactile skins with different scales and geometries while keeping the same backend design.
Probabilistic analysis of georisk from capping of contaminated sediment in Gunneklev Fjord, Norway
Authors: Le Thi Minh Hue , Lacasse Suzanne , Rønning Sigbjørn , Moseid Mari , Eek Espen 
Published: January 2024

AbstractThe seabed of the Gunneklev Fjord in south-eastern Norway is covered with exceptionally soft contaminated sediment containing mercury and dioxins. The sediments have an undrained shear strength less than 1 kPa and a variable thickness of up to 2.5 m. To reduce the potential for leaching of contaminants from these sediments, Hydro Energy AS developed a remediation plan involving capping of the sediment. Significant uncertainties are associated with the sediment's undrained shear strength and the cap thickness. An unfortunate combination of low shear strength and thick cap could cause slope failure (e.g. translational sliding of the sediment and/or bearing capacity failure (e.g. punching through). Failure, particularly slope failure, can cause spreading of the contaminants in the fjord causing serious consequences. This paper presents an assessment of the probability of slope failure associated with the contaminated sediment before and after the cap placement. Probability of bearing capacity failure is considered to have more local effect and is also discussed briefly. The study used the Monte Carlo method with random undrained shear strength and sediment thickness. The simulations show high slope failure probability when the seabed inclination was ≥ 1:50 combined with an average undrained shear strength ≤ 0.4 kPa. Based on the probabilistic analyses, a pilot field testing campaign was carried out (after this study) with 20-cm thickness cap in the “gentle” sloping area and 5-cm thickness in the “steep” areas to avoid causing a failure. The analyses were used to support evidence-based decision-making on the cap design and implementation for further field testing.
Sequence and Haplotype Analyses of Ligula intestinalis in Acanthobrama marmid (Cyprinidae) in Turkey
Authors: Kesik Harun Kaya , Celik Figen , Turk Cebrahil , Gunyakti Kilinc Seyma , Simsek Sami , Gul Abdurrahman 
Published: January 2024

Abstract
Purpose
Ligulosis caused by Ligula intestinalis adversely affects the fisheries carried out in the lakes and ponds, causing economic losses in the fish industry. In this study, it was aimed to reveal the molecular characterization of L. intestinalis isolates obtained from woodfish (Acanthobrama marmid) in Keban Dam Lake in Elazig province of Turkey by using mt-CO1 gene sequences and to determine the genetic differences and haplotypes between the isolates.

Methods
In the examination made in terms of L. intestinalis, the intestine of the fish was opened with the help of fine-tipped scissors, the contents were allowed to come out, and the parasites were taken into a petri dish containing phosphate buffered saline (PBS). Then, L. intestinalis plerocercoids were taken into 15 ml falcon tubes containing 70% ethanol and stored at − 20 °C until further analysis. From each isolate, total gDNA was extracted from the plerocercoids. A partial (480 bp) mt-CO1 gene was amplified by PCR and sequenced unidirectionally. The final size of the trimmed sequences was 392 bp for 43 sequences. Sequence and haplotype analyses were performed, followed by phylogenetic analyses.

Results
All isolates were confirmed as L. intestinalis by BLAST analysis. In addition, 87 nucleotide mutation positions were determined among 43 CO1 gene sequences. As a result of the haplotype network performed for the mt-CO1 gene region of L. intestinalis isolates; arranged in a star-like configuration with the main haplotype (Hap05), separated from other haplotypes by 1–6 mutation steps, and 29 haplotypes were identified, covering 13.9% (6/43) of the total isolates. Also, 75 variable (polymorphic) sites were determined, 52 of which were parsimony informative sites.

Conclusions
The molecular characterization of L. intestinalis in woodfish (A. marmid) was identified for the first time in Turkey.
Professionally led support groups for people living with advanced or metastatic cancer: a systematic scoping review of effectiveness and factors critical to implementation success within real-world healthcare and community settings
Authors: Li Zhicheng , Laginha Kitty-Jean , Boyle Frances , Daly Michele , Dinner Fiona , Hirsch Pia , Hobbs Kim , Kirsten Laura , Mazariego Carolyn , McAuley Ros , O’Brien Mary , O’Reilly Amanda , Taylor Natalie , Tobin Lisa , Lewis Sophie , Smith Andrea L 
Published: January 2024

Abstract
Purpose
To examine the effectiveness of professionally led support groups for people with advanced or metastatic cancer, and identify factors critical to implementation success within real-world settings.

Methods
Databases (MEDLINE; PsychINFO; CINAHL) and grey literature were searched for empirical publications and evaluations. Articles were screened for eligibility and data systematically extracted, charted and summarised using a modified scoping review methodology. Implementation factors were mapped using Proctor’s implementation framework and the Consolidated Framework for Implementation Research 2.0.

Results
A total of 1691 publications were identified; 19 were eligible for inclusion (8 randomised controlled trials, 7 qualitative studies, 2 cohort studies, 2 mixed methods studies). Most (n=18) studies focused on tumour-specific support groups. Evidence supported professionally led support groups in reducing mood disturbances (n=5), distress (i.e. traumatic stress, depression) (n=4) and pain (n=2). Other benefits included social connectedness (n=6), addressing existential distress (n=5), information and knowledge (n=6), empowerment and sense of control (n=2), relationships with families (n=2) and communication with health professionals (n=2). Thirteen studies identified factors predicting successful adoption, implementation or sustainment, including acceptability (n=12; 63%), feasibility (n=6; 32%) and appropriateness (n=1; 5%).
Key determinants of successful implementation included group leaders’ skills/experience, mode of operation, travelling distance, group composition and membership and resourcing.

Conclusions
Professionally led tumour-specific support groups demonstrate effectiveness in reducing mood disturbances, distress and pain among patients. Successful implementation hinges on factors such as leadership expertise, operational methods and resource allocation.

Implications for Cancer Survivors
Professionally led support groups may fill an important gap in supportive care for people with advanced or metastatic cancer.
Examining the Influence of Zinc Oxide Nanoparticles and Bulk Zinc Oxide on Rat Brain Functions: a Comprehensive Neurobehavioral, Antioxidant, Gene Expression, and Histopathological Investigation
Authors: Goma Amira A. , Salama Alyaa R. , Tohamy Hossam G. , Rashed Rashed R. , Shukry Mustafa , El-Kazaz Sara E. 
Published: January 2024

AbstractThe study aimed to assess the impact of zinc oxide nanoparticles (ZnONPs) on rats’ neurobehavior compared to bulk zinc oxide (BZnO). Thirty male Sprague-Dawley rats were randomly assigned to five groups. The control group received Tween 80 (10%), while the ZnONP groups were given ZnONPs at 5 and 10 mg/kg body weight dosages, and the bulk zinc oxide (BZnO) groups received BZnO at the same dosages. Behavioral observations, neurobehavioral examinations, and assessments of brain tissue oxidative markers, neurotransmitter levels, and histopathological changes were performed. The results indicated that ZnONP at a dosage of 5 mg/kg improved general behavior, locomotor activity, memory, and recognition and reduced fearfulness in rats. Conversely, the higher dosage of 10 mg/kg and the bulk form had adverse effects on general behavior, locomotor activity, and learning ability, with the bulk form demonstrating the most severe impact—znONP-5 treatment increased antioxidant enzyme levels and decreased inflammatory markers. BZnO-5 exhibited lower oxidative stress markers, although still higher than BZnO-10. Furthermore, ZnONP-5 and BZnO-5 increased neurotransmitter levels compared to higher dosages. ZnONP-5 upregulated the expression of brain-derived neurotrophic factor (BDNF) mRNA, while BZnO-5 showed increased BDNF mRNA expression and decreased expression of genes related to apoptosis and inflammation. In summary, ZnONPs at 5 mg/kg demonstrated positive effects on rat brain function and behavior, while higher dosages and the bulk form had detrimental effects. In conclusion, the studies emphasized the importance of further assessing various doses and forms of zinc oxide on brain health, highlighting the significance of dosage considerations when using nanomaterials.
Doing Housing First und Wohnraumakquise
Authors: Sowa Frank , Tissot Anna Xymena , Sellner Nora 
Published: January 2024

ZusammenfassungWohnungslosigkeit ist in Deutschland ein bestehendes Phänomen extremster Armut. Der in den USA entwickelte Ansatz Housing First wird als Paradigmenwechsel in der Wohnungsnotfallhilfe diskutiert, indem er am dringendsten Bedarf wohnungsloser Menschen im Hilfeprozess als Erstes ansetzt: der bedingungslosen Bereitstellung einer eigenen Wohnung. Der Housing First-Ansatz wurde bereits in den USA, Kanada und europäischen Ländern erfolgreich erprobt und stellt das Menschenrecht auf Wohnen sowie die Selbstbestimmung im gesamten Hilfeprozess in den Vordergrund. Auch in Deutschland etablierten sich in den vergangenen Jahren Housing First-Modellprojekte. Ziel des explorativen Forschungsvorhabens ist es, Erkenntnisse über die Selbstverständnisse, Perspektiven und Aushandlungen zentraler Akteur*innen sowie Mechanismen der Umsetzung von solchen Modellprojekten in Nordbayern zu gewinnen, die sich als Housing First-Projekte verstehen. Dabei steht weder eine Testung der Prinzipientreue, noch die Prüfung der Mindestansprüche von Housing First-Projekten im Vordergrund der Betrachtung. Vielmehr sollen anhand qualitativer Forschungsmethoden die individuellen Erfahrungen, subjektiven Deutungen und Relevanzsetzungen der zentralen Akteur*innen im Umgang und Aushandeln mit den Housing First-Grundprinzipien in ihren Modellprojekten vor Ort rekonstruiert werden. Berücksichtigt werden die Perspektiven von Initiator*innen, Fachkräften der Wohnraumakquise, Sozialarbeiter*innen, (ausgeschiedenen) neuen Mieter*innen sowie Vermieter*innen. Die leitfadengestützten verstehenden Interviews werden mithilfe von inhaltsanalytischen sowie rekonstruktiven Methoden ausgewertet.
Further Investigation on Sexual Abuse Experiences: Revisiting the Psychometric Properties of the Sexual Abuse History Questionnaire and the Content of its Open-Ended Item
Authors: Buczó Dóra , Koós Mónika , Nagy Léna , Demetrovics Zsolt , Bőthe Beáta 
Published: January 2024

Abstract
Introduction
Numerous studies have assessed sexual abuse (SA) in association with psychological consequences, psychiatric disorders, or somatic disorders. However, assessing such a complex psychological construct faces both methodological and theoretical difficulties.

Method
The aim of this study was to examine the validity and reliability of the Sexual Abuse History Questionnaire (SAHQ) in a large, non-clinical sample (N = 24,715) and to identify other potential manifestations of sexual abuse using an open-ended question (e.g., groping, non-physical coercion, consent regarding sexual health, and the reproductive system).

Results
Two subsamples were created to perform both EFA and CFA, since no pre-established factor structure existed for the scale. The exploratory and confirmatory factor analyses identified a one-factor structure in sexual abuse both in childhood (CSA) and adolescence/adulthood (AASA). AASA and CSA showed a moderate positive correlation in both subsamples. Both AASA and CSA correlated positively with compulsive sexual behavior, sexual dysfunction, and number of sexual partners and negatively with problematic pornography consumption, although these associations were weak. Our qualitative analysis indicated eight additional categories of SA that the scale did not measure.

Conclusions
Our quantitative analyses showed adequate reliability but insufficient criterion validity for the SAHQ. Our qualitative analyses indicated that the scale is presumably not able to measure sexual abuse in its full complexity.

Policy Implications
The present research may point to the need to apply broader definitions of sexual abuse when it comes to designing interventions or treatment for SA survivors, as they can result in more personalized, inclusive, and effective intervention programs.
Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies
Authors: Lam Thua-Phong , Tran Ngoc-Vi Nguyen , Pham Long-Hung Dinh , Lai Nghia Vo-Trong , Dang Bao-Tran Ngoc , Truong Ngoc-Lam Nguyen , Nguyen-Vo Song-Ky , Hoang Thuy-Linh , Mai Tan Thanh , Tran Thanh-Dao 
Published: January 2024

AbstractDiabetes mellitus remains a major global health issue, and great attention is directed at natural therapeutics. This systematic review aimed to assess the potential of flavonoids as antidiabetic agents by investigating their inhibitory effects on α-glucosidase and α-amylase, two key enzymes involved in starch digestion. Six scientific databases (PubMed, Virtual Health Library, EMBASE, SCOPUS, Web of Science, and WHO Global Index Medicus) were searched until August 21, 2022, for in vitro studies reporting IC50 values of purified flavonoids on α-amylase and α-glucosidase, along with corresponding data for acarbose as a positive control. A total of 339 eligible articles were analyzed, resulting in the retrieval of 1643 flavonoid structures. These structures were rigorously standardized and curated, yielding 974 unique compounds, among which 177 flavonoids exhibited inhibition of both α-glucosidase and α-amylase are presented. Quality assessment utilizing a modified CONSORT checklist and structure–activity relationship (SAR) analysis were performed, revealing crucial features for the simultaneous inhibition of flavonoids against both enzymes. Moreover, the review also addressed several limitations in the current research landscape and proposed potential solutions. The curated datasets are available online at https://github.com/MedChemUMP/FDIGA.
Graphical Abstract
Combined experimental and theoretical approach to improve measurement accuracy of temperature-dependent reflectance of copper for near-infrared lasers
Authors: Mattern Manuel , Kukreja Lalit Mohan , Ostendorf Andreas 
Published: January 2024

AbstractThe low process stability of laser welding of copper with near-infrared lasers requires precise input data for process control and meaningful simulations. But meanwhile, available datasets of temperature-dependent reflectance or absorptance for near-infrared lasers on copper do not show good agreement between the different sources and often do not include the fusion process, which is of crucial importance for realistic laser welding simulations. Additionally, most of the datasets are only calculated. Therefore, in a previous study, temperature-dependent reflectance measurements were performed on electro tough-pitch copper using a near-infrared laser. The measurements revealed a reflectance drift, which was induced by the setup behavior during heating, and the time-dependence of chemical reactions like the redox-reaction as possible error sources. In this study, experiments on laser melting as the fundamental process of laser welding were performed, together with corresponding simulations using the measured reflectance values for oxide-reduced and for untreated copper from the previous study. Then, the simulations were compared with the experiments to estimate the accuracy of the reflectance measurements. To provide context, the same simulations were also conducted using reflectance datasets from other authors. In a second step, the reflectance data were corrected with respect to the reflectance drift and the effects of redox reactions were adapted to the conditions of the laser melting experiments. Using the resulting reflectance curves, an improved agreement of simulation results and the experiments was achieved over a range of different test cases, without the necessity of correction factors in the simulation model.
Potential of thermography for the monitoring of DED-Arc processes
Authors: Müller Johanna , Hensel Jonas 
Published: January 2024

Abstract
Thermography is a technique that uses, e.g., an infrared camera to visualize and measure the temperature of an object. It is often used in industrial and scientific applications to identify areas of heat loss, overheating, and other thermal anomalies. In the context of the DED-Arc (Direct Energy Deposition) process, thermography can be used to monitor the process and evaluate the temperature profile of the produced part. This can help to ensure the quality and reliability of the product, as well as to predict the resulting mechanical properties of the produced part. However, for other AM processes like LPBF (laser powder bed fusion), thermography is already used in industrial applications while for DED-Arc it is still a challenge to reliably determine the dynamically changing emission coefficient, as the emissivity strongly depends on the surface conditions. This means the emission coefficient differs for changes in surface conditions like impurities from soot and annealing colors. This work focuses on the potential of thermography for monitoring the DED-Arc process. A workflow for generating a calibration function for the emission coefficient ε is presented. In the context to the focus of this work, the resulting ε(T) function differentiates between the first three deposited layers and shows the change of emissivity for higher temperatures. This function is then used to correct the measured temperature profile with regard to different surface conditions and thus emission coefficients of a DED-Arc part.

Highlights
1. Temperature-dependent function for correcting the emissivity for DED-Arc with steel was defined.
2. Emissivity is also influenced by the purity of the surface, leading to higher emissivity coefficients in layers that are previously deposited.
3. t8/5 times are also affected by a wrongly set emission coefficient; deviations from the corrected t8/5 time depend on the cooling speed.