bluuebunny/crossref_metadata_2025_split huggingface dataset:
PP118 The Value Of New Antibiotic Treatment Strategies In Zhejiang Province, China
Authors: Wenqianzi Yang , Xuemei Zhen , Danhong Yang , Yixi Chen , Peng Dong , Al-Taie Amer , Hengjin Dong 
Published: December 2023

IntroductionThe rising antimicrobial resistance (AMR) and the difficulty in developing new antibiotics are causing a global public health problem. This analysis aims to better understand the clinical and economic value of new antibiotic treatment strategies, in order to inform clinical and antibiotic formulary decisions.MethodsWe applied a published and validated dynamic disease transmission and cost-effectiveness model of AMR with a 10-year time horizon and discount rate of five percent to evaluate the clinical and economic outcomes of introducing a new antibiotic, namely, Ceftazidime/Avibactam (CAZ-AVI) for treating AMR infections in Zhejiang Province, China. Together with piperacillin-tazobactam (pip/taz) and meropenem, we explored the impact of six treatment strategies across three common infections (complicated intra-abdominal infection (cIAI), hospital-acquired/ventilator-associated pneumonia (HAP/VAP) and infections with limited treatment options (LTO)), and pathogens (Escherichia coli, Klebsiella spp., and Pseudomonas aeruginosa). These treatment strategies included (i) current treatment strategy (pip/taz and meropenem, no CAZ-AVI), (ii) CAZ-AVI at the third line, (iii) CAZ-AVI at the second line, (iv) CAZ-AVI at the first line, (v) first line diversity (i.e., equal pip/taz and CAZ-AVI at the first line; meropenem at the last line) and (vi) all-lines diversity (pip/taz, meropenem and CAZ-AVI used randomly and only once). The data with a total of 10,905 patients were collected from a tier-3 hospital from 2018 to 2021.ResultsUnder the current treatment strategy, the hospital length of stay (LOS) and costs over ten years were estimated to be 1,588,763 days and CNY3,898,198,802 (USD559,781,348), respectively, associated with 142,999 quality-adjusted life-years (QALYs) lost, resulting in the resistance of pip/taz and meropenem being 42.0 percent and 49.9 percent respectively. In contrast, the other five treatment strategies all have shown improved outcomes, among which the “all-lines diversity” carried the greatest benefit, saving CNY1,646.04 (USD236.37) for each additional QALY gained, with the net monetary benefit being CNY24,727,102,215 (USD3,550,811,878).ConclusionsIntroducing CAZ-AVI had positive impact on clinical and economic outcomes for treating AMR, and diversifying early the antibiotics might yield the best benefits.
PP128 A Transparent Methodology To Assess Innovativeness Of Health Technologies At Marketing Authorization Time
Authors: Gargano Ludmila , Freitas Isabela , Henriques Luila , André Ariane , Álvares-Teodoro Juliana , Acurcio Francisco , Guerra Augusto 
Published: December 2023

IntroductionDefining drug innovation can be challenging and there is no consensus on what a truly “innovative” medicine is. The Italian Medicine Agency (AIFA) has established an approach to assess innovativeness based on therapeutic need, added therapeutic value, and quality of evidence. However, judgment can be subjective and may not be adequate for assessment at the time of marketing authorization, when only preliminary evidence – often from non-comparative or non-randomized trials – are available. We developed a transparent methodology for early assessment of innovativeness at the time of marketing authorization, based on AIFA guidelines.MethodsSince the perspective was the marketing authorization date, only data available at agency’s Medical Review or pivotal trial publications were considered. AIFA criteria were revisited, using oncology medicines approved in the last 10 years as a base case. Impact of preliminary evidence and inadequate study design was considered.ResultsEach assessment should refer to the first approved specific indication and predefined clinically relevant outcomes. When more than one study was presented, best methodological quality, larger sample and/or longer follow-up was selected. Four domains were established: Therapeutical need: existence and clinical benefits of alternative therapies; Clinical benefit added when compared to those alternatives; Suitability of study design considering adequate comparator group, relevant outcome assessed and randomization; Risk of bias. For each domain, clear and specific criteria were defined in consensus by a group of experts in health technology assessment (HTA) and were applied to all cancer drugs evaluated.ConclusionsEfficacy evidence available for marketing authorization are often based on preliminary data, arising from single randomized clinical trials or even non-comparative studies, which difficult early assessments of innovativeness. For this reason, transparent and reproducible methodologies can be useful not only to HTA bodies, but also for other key stakeholders in the pharmaceutical market, such as investors, researchers, doctors, and governments.
PP145 The Impacts Of The Corona Virus Disease 2019 Pandemic On Bariatric Surgeries In The Private Healthcare In Brazil
Authors: Kelles Silvana , Pereira Camila , Martins Carina , Reis Daniel , Azevedo Ernesto , Ribeiro Geraldo , Zocrato Karina , Carvalho Lélia , Freitas Marcela , Horta Maria , Barbosa Mariana , Talim Mariza , Borin Marcus 
Published: December 2023

IntroductionThe Corona Virus Disease 2019 (COVID-19) pandemic has impacted the functioning of health systems, imposing the need for adaptations. Elective surgeries also needed to adapt, and research has shown higher mortality in newly infected surgical patients after or during procedures. Thus, was recommended the suspension of elective surgeries during the pandemic. Early studies evaluating the effect of COVID-19 pandemic on bariatric surgery have reported a substantial reduction in procedures performed.MethodsThis retrospective study evaluated the impact of the suspension of bariatric surgeries for a Brazilian Health Maintenance Organization: UNIMED-BH, based on the analysis of data from before and during the pandemic of COVID-19.ResultsThere were 2,641 bariatric procedures conducted in 2019 with a 14.1 percent reduction in volume to 2,314 procedures in 2020. In 2021, there were 2,813 bariatric procedures and 1,700 procedures were observed from January to August 2022. Therefore, it appears that in 2022 the demand for bariatric procedures will be similar to the year 2019, which was before the COVID-19 pandemic.ConclusionsFrom the analysis of the data, a decrease in bariatric surgical volume was evidenced during the year 2020 when compared to 2019. Post-pandemic, monitoring is necessary to assess whether the system was able to meet the demand for bariatric surgical procedures.
COVID-19 vaccine hesitancy in Turkey: A systematic review and meta-analysis
Authors: Gulle Bugra Taygun , Oren Meryem Merve , Dal Tuba 
Published: December 2023

Abstract
This systematic review and meta-analysis aims to estimate the prevalence of coronavirus disease 2019 (COVID-19) vaccine hesitancy in Turkey, which can aid future health policies and strategies. A comprehensive search was conducted on various databases using keywords related to COVID-19 vaccine hesitancy in Turkey. Quality assessment was performed using Joanna Briggs Institute (JBI) checklist for prevalence studies. Data extraction was conducted. The random effect model (DerSimonian and Laird method) was used in pooled prevalence data analysis (95% confidence interval [CI]). A total of 1,072 articles were identified. After removing duplicates and excluding articles, 61 articles remained for bias assessment. Among these, 19 articles with low risk of bias were included in the review and meta-analysis. Total population included in the analysis was 15,164, vaccine hesitancy was 30.5% (95% Cl: 24.3–36.8%). Prevalence of the vaccine hesitancy was found to be 39.8% (95% Cl: 31.4–48.2%) in studies conducted before the initiation of vaccination, while in studies conducted after the commencement of vaccination, hesitancy was 20.4% (95% Cl: 12.9–28%). We suggest conducting high-quality studies in different populations to understand the level of vaccine hesitancy, as many of the previous studies have mainly focused on healthcare workers and students, and rest were community-based studies, which have generally shown high bias. Also, we suggest that early vaccination can reduce vaccine hesitancy.
Prevalence and determinants of goitre among children of South Kordofan state, Sudan, 2021: an urgent need for effective implementation of universal salt iodisation
Authors: Abdalla Azza Elfadil , Altahir Anfal Mahmoud , Hasabo Elfatih A. , Alrawa Salma Salah , Elazrag Amna Mutasim , Ahmed Hayat Abdoallah , Ali Hiba Abubakr , Abdelrazig Ibrahim Mysara , Ahmed Mohamed Yaser , Alagib Mohamed Alsiddig , Siddig Musab Mohammed , Asmally Rofida Salah , Mohamedelrasheed Salma Mohamed , Elnaiem Walaa Abdulgadir , Malik Elfatih Mohammed 
Published: December 2023

Abstract

Objective:
This study aimed to determine the prevalence and determinants of goitre among children aged 6–12 years at South Kordofan state.

Design:
This was a cross-sectional facility-based study.

Setting:
The study was conducted in twenty villages of South Kordofan state during a medical mission.

Participants:
All 575 school-age children (6–12 years) who attended the medical day were examined for clinical assessment of goitre.

Results:
The prevalence of goitre among children of South Kordofan was 42·8 % (grade 1: 15·7 %, grade 2: 27·1 %). Only 24·2 % of caregivers reported using iodised salt. Mothers working as farmers (OR: 3·209, CI 95 % 1·437, 7·167; P = 0·004) and children of Darforian tribes (OR: 21·799, CI 95 % 2·566, 185·226; P = 0·005) were found to be significantly associated with higher prevalence of goitre among children. This contrasts with children of African tribes, where they were found to have less goitre prevalence (OR: 0·432, CI 95 % 0·213, 0·875; P = 0·02). Iodised salt utilisation (OR = 0·523, CI 95 % 0·320, 0·854; P = 0·01) was found associated with a lower prevalence of goitre.

Conclusion:
Even though National Iodine Deficiency Disorders control programs were initiated in Sudan more than 25 years ago, the prevalence of goitre among children in South Kordofan state was alarming (42·8 %). Efforts to improve access to iodised salt, increase utilisation and raise awareness are urgently needed.
PIM1 drives lipid droplet accumulation to promote proliferation and survival in prostate cancer
Authors: Chauhan Shailender S. , Casillas Andrea L. , Vizzerra Andres D. , Liou Hope , Clements Amber N. , Flores Caitlyn E. , Prevost Christopher T. , Kashatus David F. , Snider Ashley J. , Snider Justin M. , Warfel Noel A. 
Published: December 2023

AbstractLipid droplets (LDs) are dynamic organelles with a neutral lipid core surrounded by a phospholipid monolayer. Solid tumors exhibit LD accumulation, and it is believed that LDs promote cell survival by providing an energy source during energy deprivation. However, the precise mechanisms controlling LD accumulation and utilization in prostate cancer are not well known. Here, we show peroxisome proliferator-activated receptor α (PPARα) acts downstream of PIM1 kinase to accelerate LD accumulation and promote cell proliferation in prostate cancer. Mechanistically, PIM1 inactivates glycogen synthase kinase 3 beta (GSK3β) via serine 9 phosphorylation. GSK3β inhibition stabilizes PPARα and enhances the transcription of genes linked to peroxisomal biogenesis (PEX3 and PEX5) and LD growth (Tip47). The effects of PIM1 on LD accumulation are abrogated with GW6471, a specific inhibitor for PPARα. Notably, LD accumulation downstream of PIM1 provides a significant survival advantage for prostate cancer cells during nutrient stress, such as glucose depletion. Inhibiting PIM reduces LD accumulation in vivo alongside slow tumor growth and proliferation. Furthermore, TKO mice, lacking PIM isoforms, exhibit suppression in circulating triglycerides. Overall, our findings establish PIM1 as an important regulator of LD accumulation through GSK3β-PPARα signaling axis to promote cell proliferation and survival during nutrient stress.
Insights into the various mechanisms by which Shewanella spp. induce and inhibit steel corrosion
Authors: Philips Jo , Procopio Luciano , Marshall Ian P. G. 
Published: December 2023

AbstractShewanella species are frequently selected as model strains to investigate microbially influenced steel corrosion. This selection is due to their relevance for corrosion, but also because of their easy cultivation in aerobic media. Unfortunately, these cultivation advantages do not lead to a straight-forward interpretation of their corrosion inducing or inhibiting mechanisms. The metabolic versatility of Shewanellae indeed enables a wide variety of corrosion mechanisms. This work reviews the metabolic capacities and the extracellular electron transfer mechanisms of Shewanellae and explains how these abilities lead to the various mechanisms by which Shewanellae induce and inhibit corrosion. It should be emphasized that the medium composition (presence of electron donor, acceptor, carbon source) strongly affects which mechanism is in play. Overall, this work concludes that Shewanellae model strains offer great opportunities to study corrosion, thanks in part due to genetic engineering options, but the full complexity of their corrosion processes should always be kept mind.
Enhancement of intra-cardiac flow-field data using adaptive Kernel filtering
Authors: Banerjee Shataneek , Ghosh Amardip , Pal Prasanta 
Published: December 2023

AbstractA method of determining the optimal kernel size for filtering noise in vortex dominated flow-fields, as found in the cardiac chambers is presented in this paper. Using synthetic flow fields generated using harmonic functions and perturbed using Gaussian noises of different amplitudes and spreads, the effect of kernel size on noise removal using the Median filter is tested systematically. It is shown that there exists an optimal kernel size at which the Median filter works best. The size of the optimal kernel is shown to be related to the vortex size. When applied to MRI generated cardiac flow-fields, the approach is seen to reveal underlying vortex patterns thereby aiding as an effective tool in the diagnosis and prognosis of cardiac diseases based on vortices as clinical biomarkers. The behavior of the restored cardiac flow fields which are filtered with the optimal kernel size and also with some values preceding and succeeding it are similar to that observed in studies with synthetic flow fields. This confirms that the optimal size of the kernel is related to the cardiac vortex size as is observed in the case of synthetic flow fields.
Circulating cytotoxic immune cell composition, activation status and toxins expression associate with white matter microstructure in bipolar disorder
Authors: Aggio Veronica , Fabbella Lorena , Poletti Sara , Lorenzi Cristina , Finardi Annamaria , Colombo Cristina , Zanardi Raffaella , Furlan Roberto , Benedetti Francesco 
Published: December 2023

AbstractPatients with bipolar disorder (BD) show higher immuno-inflammatory setpoints, with in vivo alterations in white matter (WM) microstructure and post-mortem infiltration of T cells in the brain. Cytotoxic CD8+ T cells can enter and damage the brain in inflammatory disorders, but little is known in BD. Our study aimed to investigate the relationship between cytotoxic T cells and WM alterations in BD. In a sample of 83 inpatients with BD in an active phase of illness (68 depressive, 15 manic), we performed flow cytometry immunophenotyping to investigate frequencies, activation status, and expression of cytotoxic markers in CD8+ and tested for their association with diffusion tensor imaging (DTI) measures of WM microstructure. Frequencies of naïve and activated CD8+ cell populations expressing Perforin, or both Perforin and Granzyme, negatively associated with WM microstructure. CD8+ Naïve cells negative for Granzyme and Perforin positively associates with indexes of WM integrity, while the frequency of CD8+ memory cells negatively associates with index of WM microstructure, irrespective of toxins expression. The resulting associations involve measures representative of orientational coherence and myelination of the fibers (FA and RD), suggesting disrupted oligodendrocyte-mediated myelination. These findings seems to support the hypothesis that immunosenescence (less naïve, more memory T cells) can detrimentally influence WM microstructure in BD and that peripheral CD8+ T cells may participate in inducing an immune-related WM damage in BD mediated by killer proteins.
Biological sex-related differences in whole-body coordination during standing turns in healthy young adults
Authors: Khobkhun Fuengfa , Thanakamchokchai Jenjira 
Published: December 2023

AbstractBiological sexes (male and female) have been reported to influence postural control and balance due to differences in musculoskeletal structures, hormonal factors, and neuromuscular control. These factors can contribute to the turning performance, potentially leading to an increased incidence of falls, particularly during turning. Therefore, this study aimed to explore the whole-body coordination and stepping characteristics and during standing turns in healthy adults to determine the effects of biological sex and turn speed. Fifty participants (25 males and 25 females) completed 180° standing turns on level ground. Inertial Measurement Units (XSENS) were used to measure whole-body movement turning kinematics and stepping characteristics. Moreover, clinical outcome of dynamic balance was measured by the Timed Up and Go (TUG). Participants were randomly tasked to turn at three speeds; fast, moderate, or slow to the left and right sides. Mann–Whitney U tests were used to compare the independent variables between male and females, and Friedman tests with Dunn’s tests for pairwise comparisons were used to compare between the three turning speeds within the two groups. The results demonstrated that significant differences were seen between males and females during fast turning for the leading foot onset (p = 0.048) and in the slow speed for the total step (p = 0.033), showing that these were greater in female with an increase in turn speed. In addition, significant differences were seen only in the males when comparing different speeds in the trailing foot onset latency (p = 0.035), step size (p = 0.009), and total number of steps (p = 0.002), while in the females a significant difference was found in peak head yaw velocity between fast and slow turn speeds, and moderate and slow turn speeds. Finally, there was no significant difference in TUG between groups. Therefore, these findings show differences between biological sexes in the response to whole-body coordination and step characteristics, indicating that females tend to have more changes in stepping characteristics compared to males due to differences in turning speed. This can affect their balance and stability. However, the differences in biological sex did not impact the dynamic balance and fall risk due to the lack of a significant difference shown by TUG between males and females.
Prediction of cell migration potential on human breast cancer cells treated with Albizia lebbeck ethanolic extract using extreme machine learning
Authors: Umar Huzaifa , Aliyu Maryam Rabiu , Usman Abdullahi Garba , Ghali Umar Muhammad , Abba Sani Isah , Ozsahin Dilber Uzun 
Published: December 2023

AbstractCancer is one of the major causes of death in the modern world, and the incidence varies considerably based on race, ethnicity, and region. Novel cancer treatments, such as surgery and immunotherapy, are ineffective and expensive. In this situation, ion channels responsible for cell migration have appeared to be the most promising targets for cancer treatment. This research presents findings on the organic compounds present in Albizia lebbeck ethanolic extracts (ALEE), as well as their impact on the anti-migratory, anti-proliferative and cytotoxic potentials on MDA-MB 231 and MCF-7 human breast cancer cell lines. In addition, artificial intelligence (AI) based models, multilayer perceptron (MLP), extreme gradient boosting (XGB), and extreme learning machine (ELM) were performed to predict in vitro cancer cell migration on both cell lines, based on our experimental data. The organic compounds composition of the ALEE was studied using gas chromatography-mass spectrometry (GC–MS) analysis. Cytotoxicity, anti-proliferations, and anti-migratory activity of the extract using Tryphan Blue, MTT, and Wound Heal assay, respectively. Among the various concentrations (2.5–200 μg/mL) of the ALEE that were used in our study, 2.5–10 μg/mL revealed anti-migratory potential with increased concentrations, and they did not show any effect on the proliferation of the cells (P < 0.05; n ≥ 3). Furthermore, the three data-driven models, Multi-layer perceptron (MLP), Extreme gradient boosting (XGB), and Extreme learning machine (ELM), predict the potential migration ability of the extract on the treated cells based on our experimental data. Overall, the concentrations of the plant extract that do not affect the proliferation of the type cells used demonstrated promising effects in reducing cell migration. XGB outperformed the MLP and ELM models and increased their performance efficiency by up to 3% and 1% for MCF and 1% and 2% for MDA-MB231, respectively, in the testing phase.
The trends of disease burden due to high temperature in Mainland China from 1990 to 2019 and its prediction to 2030
Authors: Zheng Jiaolong , Lin Haiyan , Ling Jingyi , Huang Jiaofeng , Li Dongliang 
Published: December 2023

AbstractThe risk of high-temperature-related diseases is increasing owing to global warming. This study aimed to assess the trend of disease burden caused by high temperatures in Mainland China from 1990 to 2019 and to predict the trend of disease burden over the next 10 years. The latest data were downloaded from the Global Burden of Disease Database (GBD) for analysis, and the disease burden related to high temperature was described by mortality and disability-adjusted life-years (DALYs) and stratified by etiology, sex, and age. Statistical analyses were performed using the R software. In 2019, there were 13,907 deaths attributed to high temperatures in Mainland China, and this was 29.55% higher than the 10,735 deaths in 1990. Overall, the age-standardized mortality and DALYs attributed to high temperatures showed a downward trend from 1990 to 2019. We observed an etiological shift in high-temperature-related diseases. The age-standardized DALYs contribution attributed to high temperatures in 1990 was mainly from communicable, maternal, neonatal, and nutritional diseases (CMNND) (21.81/100,000), followed by injury (18.30/100,000) and non-communicable diseases (10.40/100,000). In 2019, the largest contribution shifted to non-communicable diseases (10.07/100,000), followed by injuries (5.21/100,000), and CMNND (2.30/100,000). The disease burden attributed to high temperatures was higher in males than in females and increased with age. In 2030, the mortality rate and DALYs due to high temperatures are predicted to decrease further, and the largest contribution will come from chronic non-communicable diseases, the occurrence of which will remain at a high level over the next 10 years. The burden of disease due to high temperatures in Mainland China is still heavy, mainly due to population aging and an increase in non-communicable diseases.