bluuebunny/crossref_metadata_2025_split huggingface dataset:
IRMAOC: an interpretable role mining algorithm based on overlapping clustering
Authors: Yang Yaqi , Li Jun’e , Zhang Tao , Chen Lu , Huang Guirong , Lv Zhuo 
Published: January 2025

Abstract
The Industrial Internet motivates the research and development of Zero-Trust Architecture (ZTA). Role-Based Access Control (RBAC) as one of the key technologies for ZTA has become a hot topic. Role mining algorithms are crucial for RBAC and interpretable role mining receives wide attention due to its virtue of mining meaningful roles. However, the roles generated by existing algorithms have low interpretability and high time complexity, limiting their application in practice. This paper proposes an Interpretable Role Mining Algorithm Based on Overlapping Clustering (IRMAOC). It evaluates the interpretability of a role based on user similarity calculated on the permission and attribute of the role, and employs policy interpretability as the metric of a role set. IRMAOC creates a user association graph and clusters to generate candidate roles based on the graph. Then it remains the roles whose interpretability is higher than the preset threshold and re-clusters the users belonging to the other roles until the interpretability of all roles are higher than the threshold. Experimental results show that our algorithm significantly improves the interpretability of roles, reduces the Weighted Structure Complexity (WSC), and decreases time complexity compared to previous works.
Surveying the aftermath: a qualitative and semiquantitative study of post-COVID-19 sequelae in the lungs
Authors: Eapen Kurian C. , Vimala Leena Robinson , Isaac Barney , Irodi Aparna 
Published: January 2025

Abstract

Background
In this period following the COVID-19 pandemic, there is increasing evidence to indicate the presence of long-term sequelae in individuals who were infected with COVID-19. This study was performed to assess the proportion of CT abnormalities in patients who underwent CT imaging of the thorax at least 4 weeks after the date of RT-PCR confirmation of COVID-19 infection and to assess the severity of lung involvement using a semiquantitative CT scoring system in the above population.

Methods
Institutional Review Board approval was obtained for this study. We conducted a retrospective study to assess the post-COVID-19 findings on CT imaging of thorax. The cases for analysis were obtained from the radiology department database of our Institution by performing a RIS-PACS search. The CT images were analyzed both in a qualitative manner and by using a semiquantitative score, which was correlated with spirometry.

Results
A total of 192 CT imaging studies of various patients were reviewed as part of this study. The mean age of the study population was 50. The predominant CT abnormalities included ground glass opacities (87%), reticulations (77%), consolidations (52%), subpleural bands (65%), tractional bronchiectasis (59%), and air trapping (19%). The mean semiquantitative score obtained was 35.08 (range 0-80). There was a significantly higher score among diabetics and those with multiple comorbidities. There was a significant correlation between spirometric variables (FVC, FEV1) and the semiquantitative score.

Conclusion
We qualitatively assessed the spectrum of post-COVID-19 sequelae in the lungs. The common findings included ground glass opacities, reticulations, and consolidations. The severity of post-COVID-19 sequelae quantified by the semiquantitative score showed a weak to moderate correlation with spirometry.
Let us be heard: critical analysis and debate of collaborative research approaches used in implementation science research with equity-deserving populations
Authors: Gallant Sarah Madeline , Mann Cynthia , Benoit Britney , Aston Megan , Curran Janet , Cassidy Christine 
Published: January 2025

Abstract

Background
Implementation Science research completed with equity-deserving populations is not well understood or explored. The current opioid epidemic challenges healthcare systems to improve existing practices through implementation of evidence-based interventions. Pregnant persons diagnosed with opioid use disorder (OUD) is an equity-deserving population that continues to experience stigmatization within our healthcare system. Efforts are being made to implement novel approaches to care for this population; however, the implementation research continues to leave the voices of pregnant persons unheard, compounding the existing stigma and marginalization experienced.

Methods
This debate paper highlights a specific case that explores the implementation of the Eat, Sleep, Console (ESC) model of care, a function-based empowerment model used to guide the care for pregnant persons diagnosed with OUD and their infants. We establish our debate within the conceptual discussion of Nguyen and colleagues (2020), and critically analyze the collaborative research approaches, engaged scholarship, Mode 2 research, co-production, participatory research and IKT, within the context of engaging equity-deserving populations in research. We completed a literature search in CINAHL, Google Scholar, PubMed and Embase using keywords including collaborative research, engagement, equity-deserving, marginalized populations, birthparents, substance use and opioid use disorder with Boolean operators, to support our debate.

Discussion
IKT and Community Based Participatory Action Research (CBPR) were deemed the most aligned approaches within the case, and boast many similarities; however, they are fundamentally distinct. Although CBPR’s intentional methods to address social injustices are essential to consider in research with pregnant persons diagnosed with OUD, IKT aligned best within the implementation science inquiry due to its neutral philosophical underpinning and congruent aims in exploring complex implementation science inquiries. A fundamental gap was noted in IKT’s intentional considerations to empowerment and equitable engagement of equity-deserving populations in research; therefore, we proposed informing an IKT approach with Edelman’s Trauma and Resilience Informed Research Principles and Practice (TRIRPP) Framework.
Research on refined UAV inspection method of wind/solar power stations based on YOLOv8
Authors: Pu Jieyi , Zhang Qifeng , Zhao Wenbo , Zhang Wei , Qin Zengren , Zhang Yumeng 
Published: January 2025

Abstract
More and more research is focusing on the unmanned aerial vehicle (UAV) inspection of onshore wind/solar power stations; however, how to balance the contradiction between detection accuracy and efficiency is still a challenge for domestic and international researches. In this paper, for the sparse distribution of inspection targets in onshore wind/solar power stations, the YOLOv8 model is used to quickly extract information such as photovoltaic module contours and key points of wind turbine blades in the wide-angle image of the UAV. By connecting these key points in series, fine route planning of the UAV is realized, and the zoom lens is used to carry out efficient and fine inspection of photovoltaic (PV) modules and wind turbine blades. In order to accelerate the convergence of the PV module contour extraction model, this paper introduces a loss function for the difference in linear angular orientation, which improves the average IOU accuracy of the YOLOv8 model to 93%. In the extraction of key points such as the center and tip of wind turbine blades, this paper firstly adopts serpentine convolution to replace the traditional convolution operator in order to adapt the wind turbine blade features, and secondly incorporates the a priori information of the angle constraints between the blades into the loss function. Finally, multi-angle wind turbine imaging photos in desert, hill, rice field, and other scenes are quickly simulated by computer simulation software to improve the model generalization performance. The experimental results show that the improved model achieves 85.4% on the mAP50 metric, which is a 9.2% improvement over YOLOv8, and 6.2% on the more stringent mAP50:95 metric.
Machine Learning to Predict Mortality in Older Patients With Cancer: Development and External Validation of the Geriatric Cancer Scoring System Using Two Large French Cohorts
Authors: Audureau Etienne , Soubeyran Pierre , Martinez-Tapia Claudia , Bellera Carine , Bastuji-Garin Sylvie , Boudou-Rouquette Pascaline , Chahwakilian Anne , Grellety Thomas , Hanon Olivier , Mathoulin-Pélissier Simone , Paillaud Elena , Canouï-Poitrine Florence 
Published: January 2025

PURPOSE
Establishing an accurate prognosis remains challenging in older patients with cancer because of the population's heterogeneity and the current predictive models' reduced ability to capture the complex interactions between oncologic and geriatric predictors. We aim to develop and externally validate a new predictive score (the Geriatric Cancer Scoring System [GCSS]) to refine individualized prognosis for older patients with cancer during the first year after a geriatric assessment (GA).

MATERIALS AND METHODS
Data were collected from two French prospective multicenter cohorts of patients with cancer 70 years and older, referred for GA: ELCAPA (training set January 2007-March 2016) and ONCODAGE (validation set August 2008-March 2010). Candidate predictors included baseline oncologic and geriatric factors and routine biomarkers. We built predictive models using Cox regression, single decision tree (DT), and random survival forest (RSF) methods, comparing their predictive performance for 3-, 6-, and 12-month mortalities by computing time-dependent area under the receiver operator curve (tAUC).

RESULTS
A total of 2,012 and 1,397 patients were included in the training and validation set, respectively (mean age: 81 ± 6 years/78 ± 5 years; women: 47%/70%; metastatic cancer: 50%/34%; 12-month mortality: 43%/16%). Tumor site/metastatic status, cancer treatment, weight loss, ≥five prescription drugs, impaired functional status and mobility, abnormal G-8 score, low creatinine clearance, and elevated C-reactive protein (CRP)/albumin were identified as relevant predictors in the Cox model. DT and RSF identified more complex combinations of features, with G-8 score, tumor site/metastatic status, and CRP/albumin ratio contributing most to the predictions. The RSF approach gave the highest tAUC (12 months: 0.87 [RSF], 0.82 [Cox], 0.82 [DT]) and was retained as the final model.

CONCLUSION
The GCSS on the basis of a machine learning approach applied to two large French cohorts gave an accurate externally validated mortality prediction. The GCSS might improve decision making and counseling in older patients with cancer referred for pretherapeutic GA. GCSS's generalizability must now be confirmed in an international setting.
Strategies for Mitigating Cancer-Related Financial Toxicity in China: A Multiperspective Qualitative Study Based on the Socioecological Framework
Authors: Yuan Xiaoyi , Sun Yanling , Kuang Yi , Qiu Jiajia , Zhu Jing , Gu Haiyan , Xing Weijie 
Published: January 2025

PURPOSE
To explore strategies related to cancer-related financial toxicity (FT) from the perspectives of cancer survivors and stakeholders in China and to evaluate their views within the context of the social ecological model (SEM).

METHODS
Between March and July 2022, we conducted a descriptive qualitative study with semistructured interviews of 23 cancer survivors and 14 stakeholders. Qualitative content analysis on the basis of the SEM was used to analyze the data with NVivo 12.

RESULTS
Guided by the SEM, we identified 12 subthemes that described how to mitigate FT. Individual-level strategies included increasing cost-related health literacy, strengthening adherence to standardized treatments, and improving resilience to cancer and financial changes. Interpersonal-level strategies included strengthening family support and social networks. Organizational-level strategies included using evidence-based treatments, effective communication of costs, and providing financial information support. Community-level strategies included improving symptom management throughout survivorship and providing psychosocial support. Policy-level strategies included optimizing health insurance policies and promoting collaboration among medical institutions.

CONCLUSION
Our findings provide a comprehensive understanding of strategies pertaining to FT, offering insights that could support the development of future interventions. This research suggests that interventions that encompass multiple levels—individual, interpersonal, organizational, community, and policy—rather than focusing on only one level might be the most beneficial for managing FT.
Association of Germline Pathogenic Variants in
MUTYH
and Other DNA Damage Response Genes With Lung Cancer Risk Among Non-Hispanic Whites and African Americans
Authors: Trendowski Matthew R. , Lusk Christine M. , Wenzlaff Angela S. , Neslund-Dudas Christine , Purrington Kristen S. , Beebe-Dimmer Jennifer L. , Schwartz Ann G. 
Published: January 2025

PURPOSE
Although lung cancer is one of the most common malignancies, the underlying genetics regarding susceptibility remain poorly understood. We characterized the spectrum of pathogenic/likely pathogenic (P/LP) germline variants within DNA damage response (DDR) genes among lung cancer cases and controls in non-Hispanic Whites (NHWs) and African Americans (AAs).

MATERIALS AND METHODS
Rare, germline variants in 67 DDR genes with evidence of pathogenicity were identified using the ClinVar database. These P/LP variants were genotyped in a sample of 3,040 lung cancer cases and controls from the Inflammation, Health, Ancestry, and Lung Epidemiology study (NHW: n = 1,915; AA: n = 1,125) and were tested for their association with lung cancer using multivariate logistic regression adjusting for age, sex, pack-years, and race.

RESULTS

We identified 49 unique rare P/LP variants in 21 genes among 156 carriers. Approximately 5.9% of lung cancer cases and 4.2% of controls carried at least one P/LP variant. P/LP variants in DDR genes were more common in lung cancer cases, particularly those diagnosed with adenocarcinoma (odds ratio [OR], 1.46 [95% CI, 1.00 to 2.14]).
MUTYH
variants were associated with lung cancer overall (OR, 1.82 [95% CI, 1.10 to 3.12]), with the strongest associations among never smokers (OR, 3.37 [95% CI, 1.08 to 10.26]), and in individuals who do not meet current USPSTF screening criteria (OR, 2.85 [95% CI, 1.20 to 7.53]).

CONCLUSION

Germline variants in DDR genes appear to be associated with lung cancer, particularly when examined by gene subtype and morphologic subtype.
MUTYH
, a gene historically associated with colorectal and other GI malignancies, emerged as a candidate gene that should be examined in individuals who do not have a significant smoking history.
Genomic Characterization and Prognostic Significance of Human Epidermal Growth Factor Receptor 2–Low, Hormone Receptor–Positive, Early Breast Cancers From the BIG 1-98 and SOFT Clinical Trials
Authors: Luen Stephen J. , Brown Lauren C. , van Geelen Courtney T. , Savas Peter , Kammler Roswitha , Dell'Orto Patrizia , Biasi Olivia , Coates Alan S. , Gelber Richard D. , Thürlimann Beat , Colleoni Marco , Fleming Gini F. , Francis Prudence A. , Regan Meredith M. , Viale Giuseppe , Loi Sherene 
Published: January 2025

PURPOSE
To investigate whether hormone receptor–positive, human epidermal growth factor receptor 2–low (HR+HER2-low) versus HR+HER2-zero early breast cancers have distinct genomic and clinical characteristics.

METHODS
This study included HR+, HER2-negative early breast cancers from patients enrolled in the phase III, randomized BIG 1-98 and SOFT clinical trials that had undergone tumor genomic sequencing. Tumors were classified HR+HER2-low if they had a centrally reviewed HER2 immunohistochemistry (IHC) score of 1+ or 2+ with negative in situ hybridization and HR+HER2-zero if they had an HER2 IHC score of 0.

RESULTS

A total of 1,795 tumors were evaluable for this study (BIG 1-98 n = 520, SOFT n = 1,275). The frequency of HER2-low tumors was 37% and 21% in the postmenopausal BIG 1-98 and premenopausal SOFT cohorts, respectively. There were no significant differences in clinicopathologic variables between HER2-low and HER2-zero groups which was consistent across both trials. There was no significant difference in risk of distant recurrence for patients with HER2-low tumors versus HER2-zero tumors (5-year % distant recurrence-free 94.0%
v
92.8%,
P
= .61, in BIG 1-98; 89.4%
v
92.7%,
P
= .31, in SOFT, respectively). Somatic genomic profiles were similar with the exception of
MAP3K1
mutations which were more frequent in HER2-zero tumors (BIG 1-98 19%
v
5%, SOFT 11%
v
6%). Both
ERBB2
copy number and
ERBB2
gene expression abundance were significantly higher in HER2-low tumors compared with HER2-zero tumors; however, the absolute difference was small. Correlation between
ERBB2
copy number values and gene expression was modest (
r
= 0.17).

CONCLUSION

In two large clinical trials with centrally reviewed HER2 IHC, our findings do not support HER2-low breast cancer as a distinct clinical or biologic entity among HR+HER2- early breast cancers. Absolute differences in median
ERBB2
copy number levels or gene expression are small and of unclear biologic relevance.
Panhypopituitarism in Neurosarcoidosis: Pituitary-Hypothalamic Involvement Successfully Managed With Rituximab
Authors: de Miguel Ibañez Regina , Espinosa Cárdenas Pattsy Etual , García Sáenz Manuel Ramón , Sandoval Bonilla Bayron A 
Published: January 2025

Abstract
Neurosarcoidosis (NS) is a rare form of sarcoidosis, with isolated hypothalamic-pituitary involvement being exceptionally uncommon. We report a 20-year-old woman presenting with polyuria, galactorrhea, amenorrhea, and substantial weight loss. Hormonal evaluation revealed hypopituitarism with arginine-vasopressin deficiency and hyperprolactinemia. Magnetic resonance imaging demonstrated pituitary stalk thickening and suprasellar extension, initially suggestive of hypophysitis. High-dose glucocorticoid therapy resulted in partial regression of the pituitary lesion but persistence of suprasellar involvement, prompting a transcranial stereotactic biopsy. Histopathological analysis confirmed isolated NS with noncaseating granulomas. The patient was treated with rituximab after partial response to glucocorticoids, achieving significant clinical and radiological improvement, although hormonal axis recovery was not observed. Hormone replacement therapy remains necessary. The case met the criteria for definitive type b NS, as no extraneural involvement was identified. This case underscores the diagnostic challenges of isolated NS and highlights the importance of considering histopathological confirmation in patients without systemic manifestations to guide treatment. Glucocorticoids are first-line therapy, but rituximab may be effective as a second-line option for refractory cases. Early diagnosis and tailored therapy are essential to improving outcomes in this rare and challenging condition.
Writing Before and Beyond Monolingualism
Authors: Behrend Megan 
Published: January 2025

Abstract
If writing studies today is engaged in a project to remake composition pedagogy apart from modern language ideologies, then medieval writing reminds us that such ideologies were not always dominant. This essay asks how medieval texts, written before monolingualism became normative, might help student writers to imagine possibilities for composing beyond monolingualism. What happens when students are invited to read Dante Alighieri's defense of his Italian vernacular in book 1 of the Convivio alongside contemporary defenses of linguistic diversity more commonly taught in the first-year writing classroom? As this experiment suggests, assigning medieval texts in composition courses offers at least two advantages to student writers in support of linguistic justice and critical language awareness learning goals. For one, contradicting a modern view of translingualism as deviation from a monolingual norm, students learn that writers have had to assume language difference, rather than homogeneity, as a condition of composition for most of history. Second, the juxtaposition of medieval and contemporary, far from flattening historical difference, prompts students to think even more specifically and critically about the conditions for and consequences of translingual practices in particular times and places.
Toward the Limits of Human Ageing Physiology: Characteristics of the 50-, 60- and 70-yr + Male Indoor Rowing World Champions
Authors: Daly Lorcan S. 
Published: January 2025

ABSTRACT

Purpose
To examine the physiological, power-duration, nutritional intake and training characteristics of the recent lightweight (- 75 kg) 50+, 60+ and 70 + yr world champion indoor rowers.

Methods
Laboratory assessments, undertaken over 2 visits, examined body composition, pulmonary function, blood lactate/ventilatory landmarks, efficiency, fat/carbohydrate oxidation, primary component time-constant to steady-state [𝜏pc]) and peak oxygen consumption (V̇O2peak). Training, performance and nutritional intake were also reported.

Results
The athletes’ world championship 2000 m times were 06:34.8, 06:44.0 and 07:15.2, respectively. Their training distribution could be considered pyramidal, with ≈65% in the moderate domain, ≈30% in heavy/severe domains and ≈5% in the extreme domain (rowing ≈67 km.week-1). The athletes demonstrated highly-developed attributes such as fat free mass (FFM; [63.4 to 68.1 kg]), forced vital capacity (4.9 to 5.5 L), 𝜏PC; [13.8 to 17.4 s]), peak power output (550 to 797 W), V̇O2peak (56.2 to 44.7 mL.kg.min-1) and critical power (217 to 288 W). Comparisons with young Olympic champion rowers suggest that age-related 2000 m performance mean power declines of -21.6 to -41.4% in world champions ≈25-, 35-, and 45-years older may be predominantly driven by 'central' factors (e.g., V̇O2peak, critical power; -18.1 to -43.8%). In contrast, 'peripheral' factors (e.g., gross efficiency, τPC; +6.1 to -25.1%) seem to display notable preservation despite ageing, aligning closely with values seen in young Olympic champions.

Conclusions
These results challenge conventional perspectives of age-related physiological capacities and decline trajectories. They also suggest that, commensurate with adequate training and nutritional provision, various physiologic systems can exhibit remarkable adaptability and sustain exceptionally high function during ageing. Finally, large differences among the athletes’ power-duration and physiological characteristics imply that achieving world-class rowing performance can be predicated by diverse cardiovascular, metabolic and neuromuscular attributes.