bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enlaces entre a psicologia e a vitimologia
Authors: Conte Raquel Furtado , Cemin Tania Maria 
Published: January 2024

A violência no Brasil é um fenômeno que se intensificou a partir da metade do século XX. Por se tratar de um tema complexo, várias áreas do conhecimento investigam causas, dinâmicas e consequências tanto para o sujeito como para a coletividade. Este artigo tem como objetivo geral o de analisar a produção bibliográfica sobre a psicologia e a vitimologia. Para isso foram realizados os seguintes passos: caracterizar a violência urbana, conceituar o estudo da vitimologia; identificar o papel da psicologia em relação à abordagem das vítimas de crimes. Trata-se de uma pesquisa básica, exploratória. Já os procedimentos técnicos da pesquisa, configuram-se como pesquisa bibliográfica que constitui numa coleta de dados de materiais já publicados como: livros, jornais, revista, sites online e artigos. Quanto aos resultados, as implicações jurídicas da vitimologia referem-se aos avanços científicos com relação ao papel da vítima no processo penal, deixando de apenas concebê-la como meio de prova para resgatar sua condição de sujeito de direitos. Nas implicações psicológicas, emerge a lacuna existente de experiências publicadas no que tange à escuta e promoção de cidadania das vítimas. Lidar com o trauma e propiciar uma escuta das vítimas pode evitar a vitimização e contribuir para a redução de danos e na readaptação ao meio com a superação dos efeitos nefastos do delito. A necessidade de pesquisas nessa área é de extrema importância para identificar políticas preventivas para garantir a paz, a partir de políticas sociais focalizadas regionalmente e de políticas relacionadas ao sistema de justiça criminal.
Биоэтика как реляционная философия действия (на примере китайской биоэтики)
Authors: Попова Ольга Владимировна 
Published: January 2024

<p>В статье показано, что формирование биоэтики в Китае осуществлялось в контексте особой социокультурной ситуации, которая привела к возникновению уникальной этической парадигмы. В отличие от западных стран в Китае значительное внимание уделяется патернализму, семейным и родственным связям, а также общественной сфере жизни, в то время как автономия пациента имеет гораздо меньшее значение и часто неактуальна. В медицинской сфере это проявляется через выраженный врачебный патернализм, высокую культуру наставничества и подчиненных отношений. Очевидно, что эта консервативная ориентация биоэтики опирается на традиционные ценности и придает предпочтение общественным интересам перед индивидуальными.</p><p>Автор приходит к выводу о том, что в китайской биоэтике, представляющей собой особую философию действия в биомедицинских ситуациях, заложено своеобразное представление о моральной агентности. На основе теории агентности М. Вальмисы, описывающей особую реляционную онтологию китайской философии, был рассмотрен феномен китайской биоэтики, в которой отношения конститутивны и первичны, не подчинены презумпции отдельных субъектов. В современном мире китайская биоэтика развивается как проект реляционной философии, формирующийся в контексте стремительного биомедицинского прогресса и делающий ставку на инновационность знания и этики, но при этом воспроизводящий некоторые архетипы традиционной китайской культуры, которые могут успешно сосуществовать с развитием науки и технологий и в некоторых аспектах его усиливать. Таким образом, важной чертой китайской биоэтики становится акцент на семейных отношениях, на реляционной модели личности, противопоставляющейся западному индивидуализму и автономии личности.</p>
Immunoregulatory properties of the dry extract of the herb <i>Cichorium intybus L.</i> in <i>in vitro</i> and <i>in vivo</i> systems
Authors: Mikhailova Irina V. , Ivanova Elena V. , Smolyagin Alexander I. , Bondarenko Anatoly I. , Sinegovets Angelina A. , Bondarenko Taisiya A. , Bekpergenova Anastasia V. 
Published: January 2024

Aim: to evaluate the effect of a dry extract of the herb of Cichorium intybus L. on the production of cytokines by human peripheral mononuclear cells in the systems in vitro and on the mass (thymus, spleen) and number of cells (thymus, spleen, bone marrow) of immune organs of mice in a model experiment of immunodeficiency in the systems in vivo.
Materials and methods. The study of the immunoregulatory properties of the dry extract of chicory herb was evaluated by the ability to change the production of cytokines on the model of mononuclear cells during co-cultivation under in vitro conditions and by the ability to restore the mass (thymus, spleen) and the number of cells (thymus, spleen, bone marrow) of the organs of the immune system of outbred mice under conditions of immunosuppression induced by methotrexate to the level of intact mice in vivo.
Results. An analysis of the immunoregulatory properties of dry extract of chicory herb in the systems in vitro showed that a solution of chicory extract increased the concentration of the anti-inflammatory cytokine IL-10 and reduced the production of pro-inflammatory cytokines TNFα, IL-6, IFNγ and anti-inflammatory cytokine IL-1Ra. Evaluation of the effect of the dry extract of chicory herb in the systems in vivo found that the dry extract of the herb of Cichorium intybus L. had no effect on the mass (thymus, spleen) and number of cells (thymus, spleen, bone marrow) of the immune system organs in intact mice and restored these parameters of the immune system in animals treated with cytostatic MTX to the level of intact animals, and the effect of the extract was comparable to the effect of the reference drug “Immunal”.
Conclusion. The dry extract of the herb of Cichorium intybus L. can be considered as a promising agent that normalizes the parameters of the immune system under conditions of MTX-induced immunosuppression, suppresses the synthesis of pro-inflammatory cytokines and stimulates the secretion of anti-inflammatory IL-10, and the activity of this extract is associated with high content of phenolic compounds. Given the above, further study of chicory herb and dry extract from it is expedient and aimed at creating new effective herbal preparations that regulate the functions of the body’s immune system.
Downregulation of RCN1 inhibits esophageal squamous cell carcinoma progression and M2 macrophage polarization
Authors: Guo Haiyang , Shu Jinghao , Hu Guangbing , Liu Bingyang , Li Jie , Sun Jinhong , Wang Xiaobo , Liu Han , Xiong Shiyu , Tang Yong , Yin Yaolin , Wang Xianfei 
Published: January 2024

Abstract

Background:Reticulocalbin 1 (RCN1) is a calcium-binding protein involved in the regulation of calcium homeostasis in the endoplasmic reticulum. The aim of this study was to explore the clinical value and biological role of RCN1 in esophageal squamous cell carcinoma (ESCC). In addition, we investigated the effect of RCN1 on the polarization of tumor-associated macrophages (TAMs).
Methods: The GSE53625 dataset from the Gene Expression Omnibus database was used to analyze the expression of RCN1mRNA and itsrelationship with clinical value and immune cell infiltration. Immunohistochemistry was used to validate the expression of RCN1 and its correlation with clinicopathological characteristics. Subsequently, transwell and cell scratch assays were conducted to evaluate the migration and invasion abilities of ESCC cells. The expression levels of epithelial–mesenchymal transition (EMT)-related proteins were evaluated by Western blot, while apoptosis was detected by flow cytometry and Western blot. Additionally, qRT‒PCR was utilized to evaluate the role of RCN1 in macrophage polarization.
Results: RCN1 was significantly upregulated in ESCC tissues and was closely associated with lymphatic metastasis and a poor prognosis, and was an independent prognostic factor for ESCC in patients. Knockdown of RCN1significantly inhibited the migration, invasion, and EMT of ESCC cells, and promoted cell apoptosis. In addition, RCN1 downregulation inhibited inhibited M2 polarization.
Conclusion: RCN1 is upregulated in ESCC patients and is negatively correlated with patient prognosis. Knocking down RCN1 inhibits ESCC progression and M2 polarization. RCN1 can serve as a potential diagnostic and prognostic indicator for ESCC, and targeting RCN1 is a very promising therapeutic strategy.
Interdisciplinary strategies for establishing a trusting relation as a pre-requisite for existential conversations in palliative care: a grounded theory study
Authors: Lagerin Annica , Melin-Johansson Christina , Holmberg Bodil , Godskesen Tove , Hjort Elin , Junehag Lena , Hagelin Carina Lundh , Ozanne Anneli , Sundelöf Johan , Udo Camilla 
Published: January 2024

Abstract

Background
Communication is central to implementing palliative care (PC) and effective interdisciplinary team functioning. Communication about existential issues is often urgent in PC, yet interdisciplinary teams frequently lack the time and education to meet these communication needs. Thus, more knowledge of existential conversations in different PC contexts is required.
Aim
This study aimed to gain an in-depth understanding of healthcare professionals’ (HCPs) experiences of existential conversations with patients with PC needs and their next-of-kin by generating a theoretical model.
Method
Seven focus-group interviews that included 26 HCPs who worked with PC patients in different care settings were carried out in 2020 and 2022. The grounded theory method was used to analyse and compare data from the interview transcripts.
Results
The HCPs’ primary concern in daily work was establishing a trusting relationship, a prerequisite for enabling existential conversations with a person with PC needs and/or their next-of-kin. The main concern was characterised by the core category maintaining presence and four categories describing interdisciplinary strategies that the HCPs used to achieve a trusting relationship and enable existential conversations in the late phase of life. Several potential barriers also hindered existential conversations. The theoretical model ‘meaningful existential conversations in PC’ was constructed.
Conclusions
The interdisciplinary strategies used to establish existential conversations, the potential barriers to these conversations and the model we present can be used as a basis for reflection in professional collaborative learning in PC, as a tool for teachers in educational PC programmes and as a guide for HCPs in PC.
Portulaca oleracea exhibited anti-coccidian activity, fortified the gut microbiota of Hu lambs
Authors: li shiheng , li Senyang , liu Shuaiqi , lu shunli , li jing , cheng Shuqi , zhang sumei , huang Shucheng , li junqiang , jian Fuchun 
Published: January 2024

Abstract

Coccidia of the genus Eimeriaare important pathogens that cause coccidiosis in livestockand poultry. Due to the expansion of intensive farming, coccidiosis has become more difficult to control. In addition, the continued use of anti-coccidiosis drugs has led to drug resistance and residue. Some herbs used in traditional Chinese medicine (TCM) have been shown to alleviate the clinical symptoms of coccidiosis, while enhancing immunity and growth performance (GP) of livestock and poultry. Previous in vitro and in vivo studies have reported that the TCM herb Portulaca oleracea exhibited anti-parasitic activities. In total, 36 female Hu lambs were equally divided into six treatment groups: PL (low-dose P. oleracea), PH (high-dose P. oleracea), PW (P. oleracea water extract), PE (P. oleracea ethanol extract), DIC (diclazuril), and CON (control). The treatment period was 14 days. The McMaster counting method was used to evaluate the anti-coccidiosis effects of the different treatments. Untargeted metabolomics and 16S rRNA gene sequencing were used to investigate the effects of treatment on the gut microbiota (GM) and GP. The results showed that P. oleracea ameliorated coccidiosis, improved GP, increased the abundances of beneficial bacteria, and maintained the composition of the GM, but failed to completely clear coccidian oocysts. The Firmicutes to Bacteroidesratio was significantly increased in the PH group. P. oleracea increased metabolism of tryptophan as well as some vitamins and cofactors in the GM and decreased the relative content of arginine, tryptophan, niacin, and other nutrients, thereby promoting intestinal health and enhancing GP. As an alternative to the anti-coccidiosis drug DIC, P. oleraceaeffectively inhibited growth of coccidia, maintained the composition of the GM, promoted intestinal health, and increased nutrient digestibility.
Settlement patterns and temporal successions of coral reef cryptic communities: implications for evaluating diversity using Autonomous Reef Monitoring Structures (ARMS)
Authors: Couëdel Marion , Dettai Agnes , Guillaume Mireille M. M. , Bonillo Céline , Frattini Baptiste , Bruggemann J. Henrich 
Published: January 2024

Abstract

Autonomous Reef Monitoring Structures (ARMS) are used worldwide to assess cryptic diversity, especially on coral reefs. They were developed as standardised tools, yet conditions of deployment, such as immersion duration and/or deployment and retrieval seasons, vary among studies. Here we studied temporal and seasonal variability in coral reef cryptic communities sampled with 15 ARMS on a single coral reef slope site at Reunion Island, Southwest Indian Ocean. Settlement patterns and temporal succession of Eukaryote communities were investigated across three immersion times (6 months, 1 year, 2 years), two immersion seasons (hot vs. cool) and three fractions (500–2000 µm, 106–500 µm, sessile) using two genetic markers (18S, COI). Both markers detected different taxa with different resolutions, but broadly similar patterns of community composition and structure. While OTU diversity of communities did not change with immersion time and season, these parameters significantly affected community structure and composition. Our results evidenced a decrease of the similarity of ARMS communities with immersion time, due to a high turnover of early colonisation stages followed by an increase in the differences in OTU richness. The small proportion of OTUs assigned at phylum level highlights the uniqueness of the Mascarene cryptobiome.
Seasonal Energy Efficiency: A Case Study of an Urban Distribution Battery Electric Truck Operating in Brazil
Authors: Lima Everton Silva , Baldo Crhistian Raffaelo , de Souza Calebe Paiva Gomes 
Published: January 2024

Abstract

Electric heavy-duty trucks fully powered by batteries are already a reality in European, North American, and Chinese cities, thanks to strict CO2 emission regulations. These regulations promote zero greenhouse gas emissions in the road transport sector through technologies such as battery-powered electric trucks (BETs). The increasing prevalence of BETs necessitates an assessment of their energy efficiency in different weather and driving conditions, since they directly impact operational costs and, thus, influence the acceptance of BETs by companies and fleet owners. In this sense, evaluating seasonal energy efficiency may drive improvements in technology performance, vehicle specifications, and driving conditions to reduce energy consumption and losses. To understand and quantify the factors affecting energy consumption and driving range in real-world driving conditions, various studies on energy efficiency have been conducted worldwide; nevertheless, South American metropolitan areas lack such attention. Therefore, this paper presents the main findings of an experimental study of BETs in terms of energy consumption, driving range, and energy recharging due to operational and climatic factors.
Endothelial Erg Regulates Expression of Pulmonary Lymphatic Junctional and Inflammation Genes in Mouse Lungs Impacting Lymphatic Transport
Authors: Chakraborty Adri , Kim Alex , AlAbdullatif Salam , Campbell Joshua , Alekseyev Yuriy , Kaplan Ulas , Dambal Vrinda , Ligresti Giovanni , Trojanowska Maria 
Published: January 2024

Abstract
The ETS transcription factor ERG is a master regulator of endothelial gene specificity and highly enriched in the capillary, vein, and arterial endothelial cells. ERG expression is critical for endothelial barrier function, permeability, and vascular inflammation. A dysfunctional vascular endothelial ERG has been shown to impair lung capillary homeostasis, contributing to pulmonary fibrosis as previously observed in IPF lungs. Our preliminary observations indicate that lymphatic endothelial cells (LEC) in the human IPF lung also lack ERG. To understand the role of ERG in pulmonary LECs, we developed LEC-specific inducible Erg-CKO and Erg-GFP-CKO conditional knockout (CKO) mice under Prox1 promoter. Whole lung microarray analysis, flow cytometry, and qPCR confirmed an inflammatory and pro-lymphvasculogenic predisposition in Erg-CKO lung. FITC-Dextran tracing analysis showed an increased pulmonary interstitial lymphatic fluid transport from the lung to the axial lymph node. Single-cell transcriptomics confirmed that genes associated with cell junction integrity were downregulated in Erg-CKO pre-collector and collector LECs. Integrating Single-cell transcriptomics and CellChatDB helped identify LEC specific communication pathways contributing to pulmonary inflammation, trans-endothelial migration, inflammation, and Endo-MT in Erg-CKO lung. Our findings suggest that downregulation of lymphatic Erg crucially affects LEC function, LEC permeability, pulmonary LEC communication pathways and lymphatic transcriptomics.
Multidirectional Analysis of Curvelet Against Skin Cancer
Authors: Kolekar Maheshkumar H. , v Vidya Lakshmi , Razak Mohamed Sikkander Abdul , G Theivanathan 
Published: January 2024

Abstract

An elevated chance of getting another melanoma is associated with a personal history of the disease. Individuals who have already had a melanoma have a 2–5% probability of getting another one later. Compared to individuals whose initial melanoma was superficial spreading melanoma, those whose first melanoma was lentigo maligns melanoma or nodular melanoma are at a greater peril of emerging a secondary dominant cancer. Melanoma risk is double in those with a special antiquity of squamous cell carcinoma. The likelihood of getting melanoma is doubled if you have a particular times past of basal cell carcinoma. In addition, melanoma risk is higher in persons with actinic keratosis than in those without the condition. An automated technique for classifying melanoma, or skin cancer, is proposed in this work. An image of gathered data is used as the input for the proposed system, and various image handling methods remain smeared to improve the picture's characteristics. The curvelet technique is used to separate benign from malignant skin cancer and to collect relevant data from these pictures so that the classifier may be trained and tested. The basic wrapper curvelet's coefficients are the characteristics that are utilized for classification. Curvelet works well with images that have cartoon edges and aligned textures. In a database of digital photos, the three-layer back-propagation neural network classifier with curvelet has 75.6% recognition accuracy.
Three-Arms PLA/PS Copolymer Based on 2,5-Dihydroxy-1,4-Benzoquinone
Authors: Ludin Dmitrii V , Bobrina Ekaterina V , Grishin Ivan D , Zaitsev Sergey D , Fedushkin Igor L 
Published: January 2024

Abstract

This study focuses on preparation of hybrid block copolymers of polylactide (PLA) and polystyrene (PS) involving 2,5-dihydroxy-1,4-benzoquinone (DHBQ) as a dual initiator. At the first stage in the presence of AcONa 2,5-dihydroxy-1,4-benzoquinone opened the lactide ring resulting in the carboxylic end-group that further provides for the PLA chain growth. The polymerization proceeds at a moderate rate to high conversion degrees to form the polymers with well-defined molecular weight (MW) characteristics. The presence of an internal DHBQ fragment in the polymer was proven by IR, UV-VIS, NMR and MALDI-TOF techniques. Obtained polymer can be considered as macroquinone (MQ). The styrene polymerization initiated by MQ/Bu3B proceeds at a moderate rate leading to the formation of hybrid three-radial PLA/PS copolymer. During the copolymer formation linear increase of Mn with conversion as well as polydispersity decrease were observed. As evidenced by relatively low content of polystyrene in the copolymer (8.1 wt. %), the process has a good selectivity. The introduction of styrene units into the copolymer allows a 4-fold increase the E modulus in comparison with the homo-PLA.
Participatory development of an mHealth intervention delivered in general practice to increase physical activity and reduce sedentary behaviour of patients with prediabetes and type 2 diabetes (ENERGISED)
Authors: Novak Jan , Jurkova Katerina , Lojkaskova Anna , Jaklova Andrea , Kuhnova Jitka , Pfeiferova Marketa , Kral Norbert , Janek Michael , Omcirk Dan , Malisova Katerina , Maes Iris , Dyck Delfien Van , Wahlich Charlotte , Ussher Michael , Elavsky Steriani , Cimler Richard , Pelclova Jana , Tufano James J , Steffl Michal , Seifert Bohumil , Yates Tom , Harris Tess , Vetrovsky Tomas 
Published: January 2024

Abstract
Background
The escalating global prevalence of type 2 diabetes and prediabetes presents a major public health challenge. Physical activity plays a critical role in managing (pre)diabetes; however, adherence to physical activity recommendations remains low. The ENERGISED trial was designed to address these challenges by integrating mHealth tools into the routine practice of general practitioners, aiming for a significant, scalable impact in (pre)diabetes patient care through increased physical activity and reduced sedentary behaviour.
Methods
The mHealth intervention for the ENERGISED trial was developed according to the mHealth development and evaluation framework, which includes the active participation of (pre)diabetes patients. This iterative process encompasses four sequential phases: (a) conceptualisation to identify key aspects of the intervention; (b) formative research including two focus groups with (pre)diabetes patients (n = 14) to tailor the intervention to the needs and preferences of the target population; (c) pre-testing using think-aloud patient interviews (n = 7) to optimise the intervention components; and (d) piloting (n = 10) to refine the intervention to its final form.
Results
The final intervention comprises six types of text messages, each embodying different behaviour change techniques. Some of the messages, such as those providing interim reviews of the patients' weekly step goal or feedback on their weekly performance, are delivered at fixed times of the week. Others are triggered just in time by specific physical behaviour events as detected by the Fitbit activity tracker: for example, prompts to increase walking pace are triggered after 5 minutes of continuous walking; and prompts to interrupt sitting following 30 minutes of uninterrupted sitting. For patients without a smartphone or reliable internet connection, the intervention is adapted to ensure inclusivity. Patients receive on average three to six messages per week for 12 months. During the first six months, the text messaging is supplemented with monthly phone counselling to enable personalisation of the intervention, assistance with technical issues, and enhancement of adherence.
Conclusions
The participatory development of the ENERGISED mHealth intervention, incorporating just-in-time prompts, has the potential to significantly enhance the capacity of general practitioners for personalised behavioural counselling on physical activity in (pre)diabetes patients, with implications for broader applications in primary care.