bluuebunny/crossref_metadata_2025_split huggingface dataset:
Permanent vs Transient Congenital Hypothyroidism in Chinese Children: Physical Growth and Predictive Nomogram
Authors: Ding Xuejing , Liu Zhiwei , Zhang Bin , Yang Yuqi , Wang Ying , Yu Bin , Long Wei 
Published: December 2023

Abstract

Context
Few reliable markers are available to distinguish transient congenital hypothyroidism (TCH) and permanent congenital hypothyroidism (PCH). Additionally, the differences in growth between TCH and PCH remain unclear.

Objective
To investigate the growth of children with TCH and PCH and develop a nomogram for early differentiation of these forms.

Methods
This retrospective study included children with TCH or PCH. The predictive efficacy of the prognostic predictors was analyzed using receiver operating characteristic analysis. Multivariate prediction models were developed. Measurements of growth were compared between groups.

Results
Patients with TCH had lower initial thyroid-stimulating hormone (TSH) than those with PCH at newborn screening (NBS). The supplementary dose of levothyroxine (L-T4) gradually decreased with age in TCH but not in PCH. The area under the curve (AUC) values of the initial TSH, L-T4 dose at 1 year of age, and L-T4 dose at 2 years of age for distinguishing TCH from PCH were 0.698, 0.71, and 0.879, respectively. The predictive efficacy of the multivariate models at 1 and 2 years of age improved, with AUC values of 0.752 and 0.922, respectively. A nomogram was built based on the multivariate model at 1 year of age. The growth did not differ between children with TCH and those with PCH. However, at 1 year of age, girls with CH exhibited higher z-scores in terms of height and weight than boys with CH.

Conclusion
TSH at NBS and L-T4 doses during treatment can be used to distinguish between PCH and TCH early in life, and the predictive efficacy can be improved using multivariable models with a visualized nomogram. At 3 years of age, patients with TCH and PCH showed similar growth.
Transcriptome Changes and Metabolic Outcomes After Bariatric Surgery in Adults With Obesity and Type 2 Diabetes
Authors: Rashid Mamoon , Al Qarni Ali , Al Mahri Saeed , Mohammad Sameer , Khan Altaf , Abdullah Mashan L , Lehe Cynthia , Al Amoudi Reem , Aldibasi Omar , Bouchama Abderrezak 
Published: December 2023

Abstract

Context
Bariatric surgery has been shown to be effective in inducing complete remission of type 2 diabetes in adults with obesity. However, its efficacy in achieving complete diabetes remission remains variable and difficult to predict before surgery.

Objective
We aimed to characterize bariatric surgery-induced transcriptome changes associated with diabetes remission and the predictive role of the baseline transcriptome.

Methods
We performed a whole-genome microarray in peripheral mononuclear cells at baseline (before surgery) and 2 and 12 months after bariatric surgery in a prospective cohort of 26 adults with obesity and type 2 diabetes. We applied machine learning to the baseline transcriptome to identify genes that predict metabolic outcomes. We validated the microarray expression profile using a real-time polymerase chain reaction.

Results
Sixteen patients entered diabetes remission at 12 months and 10 did not. The gene-expression analysis showed similarities and differences between responders and nonresponders. The difference included the expression of critical genes (SKT4, SIRT1, and TNF superfamily), metabolic and signaling pathways (Hippo, Sirtuin, ARE-mediated messenger RNA degradation, MSP-RON, and Huntington), and predicted biological functions (β-cell growth and proliferation, insulin and glucose metabolism, energy balance, inflammation, and neurodegeneration). Modeling the baseline transcriptome identified 10 genes that could hypothetically predict the metabolic outcome before bariatric surgery.

Conclusion
The changes in the transcriptome after bariatric surgery distinguish patients in whom diabetes enters complete remission from those who do not. The baseline transcriptome can contribute to the prediction of bariatric surgery-induced diabetes remission preoperatively.
On the Anatomy of the Border of the Posterior Elastic Lamina of the Cornea, in relation to the Fibrous Tissue of the Ligamentum Iridis Pectinatum
Authors: Macdonald John Denis 
Published: December 2023

ABSTRACT
On dissecting the human eye with the view of demonstrating the generally admitted metamorphosis of the whole border of the posterior elastic lamina of the cornea into the fibrous tissue from which the little tendons of the liga mentum iridis pectinatum arise, I was surprised to find that no such transformation was anywhere to be detected. The two structures, though, indeed, associated in a very intimate and peculiar manner, were nevertheless, perfectly distinct and not to be confounded with one another. This discovery led me to examine the eye of the sheep more minutely in reference to the point in question, as the pillars of the iris in that animal are very distinctly marked, being much less crowded than they are even in the ox. The result of the investigation may be simply stated as follows :
Comparison Results of Three-Port Robot-Assisted and Uniportal Video-Assisted Lobectomy for Functional Recovery Index in the Treatment of Early Stage Non-small Cell Lung Cancer: A Propensity Score-Matched Analysis
Authors: Diao Haixiao , Xu Lin , Li Xiao , Wang Yancheng , Peng Zhongmin 
Published: December 2023

Abstract
Background
Minimally invasive lobectomy is the standard treatment for early stage non-small cell lung cancer (NSCLC). The aim of this study is to investigate postoperative recovery in a prospective trial of discharged patients with early stage non-small cell lung cancer undergoing robot-assisted thoracic surgery (RATS) versus uniportal video-assisted thoracic surgery (UVATS).

Patients and Methods
This is a prospective and observational study. From 9 September 2022 to 1 July 2023, 178 patients diagnosed with NSCLC admitted to the Department of Thoracic Surgery of Shandong Provincial Hospital signed informed consent and underwent lobectomy by RATS and UVATS. The functional recovery index included MD Anderson Symptom Inventory, Christensen Fatigue Scale, EORTC QLQ-C30, and Leicester Cough Questionnaire.

Results
After propensity score-matched analysis, each group included 42 cases. For the baseline characteristics of patients, operation time (p = 0.01) and length of stay (p = 0.04) were shorter in the RATS group. The number of lymph nodes resected in the RATS group was much more than in the UVATS group. According to our investigation, appetite loss, nausea, diarrhea, and cough severity after RATS were better than after UVATS. After the first week, pain severity degree of the RATS group was higher than UVATS, while there was no difference during the second and third week. The physical score of the RATS group was higher than the UVATS group (p = 0.04), according to the Leicester Cough Questionnaire.

Conclusion
RATS was associated with severe short-term postoperative pain but less postoperative complications.
DESIGN OF THE FUNCTIONAL MODULE «BUSINESS TRIP» ON THE BASIS OF THE ECM-SYSTEM OF PLATFORM DIRECTUM
Authors: Rabovskaya Maria Ya. , Smirnova Olga N. 
Published: December 2023

The article discusses the automation of the business process of issuing a business trip based on the ECM system of platform solutions Directum using the example of an Russian organization engaged in energy sales activities. The purpose of the article is to design a module that will allow an employee to arrange a business trip without visiting the office, taking into account all the features of the legislative and regulatory framework and the capabilities of the corporate system.
The article is recommended to specialists whose work is related to the design of personnel workflow in the company.
MATHEMATICAL DESCRIPTION OF THE PROCESSES OF FUNCTIONING OF THE ELECTRIC MOTOR-GENERATOR OF A CAR WITH A HYBRID POWER PLANT
Authors: Kiselev Pavel A. , Fedotov Alexander I. , Yankov Oleg S. 
Published: December 2023

The authors of the article describe and analyze the processes of functioning of a synchronous electric motor-generator (EDG). A review of mathematical descriptions of synchronous EDG is presented. A simplified mathematical description is proposed that makes it possible to simulate the process of functioning of the hybrid propulsion system (GSU) in typical modes of movement of wheeled vehicles (CTS). The functional dependences of the current, power and torque on the rotor speed of the synchronous EDG of the Toyota Prius car are presented.
The goal is to develop a simplified mathematical description of a synchronous electric motor–generator of a car with a hybrid power plant.
The method or methodology of the work is a numerical method based on the finite – difference scheme of the Park method, using a special numerical-iterative method of composing equations of motion.
Results – a simplified mathematical description has been developed, which allows to determine the functional dependencies necessary for the analysis of the functioning of the CCC with GSU.
The scope of the results. It is advisable to apply the results obtained when modeling the processes of functioning of a synchronous electric motor-generator of a hybrid power plant of wheeled vehicles.
VIRTUAL APPLICATION FOR MULTIMODAL TOURIST PASSENGER TRANSPORTATION
Authors: Pokrovskaya Oksana D. , Rodneva Ekaterina S. , Ivanov Danila S. , Vorobyov Alexander A. , Urushev Sergey V. 
Published: December 2023

Background. This article identifies the main tourist centers of the Arkhangelsk region; developed options for tourist routes and additions to tours; describes the specifics of the application; assessed the relevance of the application for JSC “Russian Railways” and third-party organizations.
Materials and methods. Methods of mathematical modeling, system analysis, comparison, systems theory, visualization, observation, statistical method were used.
Results: it is established that the development of the scientific and technological potential and the innovative ecosystem of the holding allows ensuring the effectiveness of the company’s activities taking into account technical, technological, economic, socio-political challenges in the domestic and foreign markets.
Conclusion. The article proposes the concept of a virtual platform in the field of passenger multimodal transportation, where the passenger himself could prepare a tourist trip taking into account individual needs.
ANALYSIS OF LOGISTICS RISKS IN MODERN CONDITIONS
Authors: Pakulina Elena V. , Pokrovskaya Oksana D. , Migrov Alexander A. 
Published: December 2023

Background. The article is devoted to the analysis of the state of the transport and logistics system of Russia in the context of the sanctions policy of the West, the classification of logistics chains, the identification of factors and risks affecting the stability of logistics flows in modern conditions.
Materials and methods. Materials from open Internet sources, logistics theory, systems theory, systems approach, comparison were used.
Results. An analytical review of the situation of Russia’s transport and logistics systems in the context of sanctions imposed by Western countries in 2022 was carried out. The risks affecting or capable of affecting the development and sustainability of logistics chains are identified.
Conclusion. Based on the results of the study, a new classification of logistics chains is proposed, taking into account changes in the construction of the logistics business, as well as a new standard logistics chain operating under sanctions.
VOICE INFORMATION IN JSC “RUSSIAN RAILWAYS”
Authors: Yarmolinsky Fyodor A. , Pokrovskaya Oksana D. , Melikov Marat I. 
Published: December 2023

Background. The work is devoted to the study of the processes of interaction between the company and consumers within the framework of the information services provided in order to improve or innovate the methods of voice communication for further operation and automation; as well as to substantiate the need for local research through the growth of automation of interaction and the speed of obtaining and perception of information.
Materials and methods. Materials from open sources on the Internet, simulation modeling, data analysis, systems theory, system approach.
Results. Information systems at Russian Railways using voice information methods have been studied, the area within which automation of user interaction with the system is possible has been analyzed, a simulation model of customer interaction with the system using voice information has been built to ensure the issuance of information on request.
Conclusion. Based on the results of the study, a solution was proposed for automation in the field of event-based informing of customers using the transport services of Russian Railways, company employees in order to improve information processing and automation of work with it. The proposed model will demonstrate and justify the issuance, processing and transmission of information for the transition to the introduction of voice information, through an assessment of the perception and reaction of the company’s employees to the implementation of audio accompaniment and interaction with the system through voice. As a result, it is proposed to develop a model reflecting the possibility of working with an information system using voice guidance and information.
EFFICIENCY OF THE ORGANIZATION OF THE MAINTENANCE POINT AT THE RAILWAY STATION
Authors: Pakulina Elena V. , Pokrovskaya Oksana D. , Migrov Alexander A. 
Published: December 2023

Background. The article is devoted to the description of the design modeling of the brake testing point with its further modernization into a maintenance point at a passenger station in the St. Petersburg transport hub.
Materials and methods. Materials from open Internet sources, logistics theory, systems theory, systems approach, project modeling, economic justification, comparison “as is” and “as will be” were used.
Results. Based on the results of the analysis of the average downtime of one train during maintenance at the service station, the economic effect was determined.
Conclusion. Based on the results of the study, a solution was proposed for the organization of a maintenance point at the St. Petersburg – Finlandsky railway station with an appropriate feasibility study. With the application of the proposal, it is possible to improve the quality performance of the railway and optimize costs. It has been established by calculation that the presence of a technical service point at the St. Petersburg – Finlyandsky railway station will allow trains to move along a given route without the need for a secondary technical inspection at the St. Petersburg – Sortirovochny – Moskovsky station.
AUTOIMPORT OF A LARGE VOLUME INFORMATION INTO A DATABASE USING THE PYTHON PROGRAMMING LANGUAGE
Authors: Krapivin Roman R. , Filatov Yuri M. , Gareeva Gulnara A. , Faizullina Aigul G. , Myshkina Irina Yu. 
Published: December 2023

The article discusses an efficient and automated way to import large amounts of data from Excel tables into a database. In various projects, there are tasks in which the flow of huge data, such as logs of program operations or manual operations performed at work sites, is vital for effective analysis.
Purpose – development of a module for automatic import of a large amount of data from Excel format into a database.
Method or methodology of work: the article discusses a method that implements automatic import of data from Excel tables into a Postgresql database.
Result: developed its own unique module that is able to process huge Excel tables and import them into a Postgresql database without manual operations.
Scope of the results: the data obtained, which are stored in the database, should be used to identify high-yield accounts for subsequent investment.
INFLUENCE OF SHOCK ABSORBER PROPERTIES ON TIRE LATERAL FORCE
Authors: Tikhov-Tinnikov Dmitry A. 
Published: December 2023

The article examines how the damping properties of the suspension system of a vehicle affect the process of forming a lateral reaction in the contact patch of a tire and the supporting surface. A mathematical model of a car quarter, a tire stretched string model, and a road surface microprofile generator were used in the study. The dependences of normal and lateral reactions along the distance traveled for three classes of roads were obtained with a change in the parameter characterizing the damping properties of the vehicle suspension. Mathematical statistics methods were used to analyze the dependences. It was found that the average value of the normal load changes little with a decrease in the damping properties of the suspension, while the standard deviation increases. The average value of the lateral force is reduced by 22%, with the standard deviation increasing by 1.6 times. The use of the Kolmogorov-Smirnov criterion for the analysis of implementations of lateral forces makes it possible to determine the permissible range of nominal values of the parameters of the technical condition of vehicle suspension shock absorbers.
Purpose. Obtaining and analyzing patterns that describe the change in the lateral reaction of a car tire when it moves under the action of a lateral force and suspension vibrations, as well as when changing the damping properties of a shock absorber.
Methodology. In the article were used the methods of mathematical modeling and also statistical methods of the analysis.
Results. Dependences have been obtained that characterize the influence of the damping properties of the suspension on the magnitude of the lateral reaction when the wheel moves along a road with bumps and under the action of a lateral force.
Practical implications. It is expedient to apply the received results by the organizations and institutions involved in the development of methods and means of diagnosing vehicles.
EXPERIMENTAL STUDY OF THE PERFORMANCE CHARACTERISTICS OF SHOCK ABSORBERS
Authors: Batjargal N. , Tikhov-Tinnikov Dmitry A. , Fedotov Alexander I. 
Published: December 2023

The article discusses the methodology for determining the performance characteristics of Toyota Prius 20 shock absorbers. The study was conducted using a stand for the diagnosis of shock absorbers developed by the Department of Road Transport of INRTU (Irkutsk National Research Technical University). Tests were carried out for five front suspension shock absorbers, one – a new serviceable shock absorber, the rest – shock absorbers that were previously in operation. The experimental dependences of the change in the resistance force of the shock absorber on the speed of movement of its rod are analyzed. The level of operational characteristics of the shock absorber under study was determined by comparing the obtained parameters with the parameters of the new shock absorber.
The results of experimental studies are presented in the form of operational characteristics of tested shock absorbers and indicators that determine the level of operational characteristics of shock absorbers. The developed methods and the equipment implementing them make it possible to determine the functional dependencies and the level of performance of shock absorbers that were in the operating conditions of the vehicle.
The level of depression, anxiety and job satisfaction among young Contact Centre employees during the COVID-19 pandemic
Authors: Juraś-Darowny Małgorzata , Król Magdalena , Chodkiewicz Jan , Talarowska Monika Ewa 
Published: December 2023

Aim of the studyThe aim of the study is to determined the relationships between symptoms of depression,and the levels of stress,anxiety and job satisfaction among ContactCentre employees and internal employees.The study also examines whether the place of work(remote work vs.office work)differentiates these participants regarding experienced anxiety, depression symptoms,job satisfaction.Subject or material and methodsThe study was conducted from October2021 to March2022.It included a total of 61 people aged between 18-45,employed at a Polish bank. Mental state and job satisfaction were assessed using the Job Satisfaction Scale(SSP),PerceivedStressScale(PSS-10),State and Trait Anxiety Inventory (STAI) and BeckDepressionInventor(BDI).ResultsNo statistically significant differences in the intensity of perceived stress or symptoms of depression and anxiety were found between the Internal and Contact Centre employees;however, poorer mental functioning was noted in the latter group.The level of job satisfaction in the studied groups significantly correlated with the severity of depressive symptoms(R=-0.427;p<0.001),intensity of perceived stress(R=-0.484,p<0.001),level of anxiety as a state(R=-0.468;p<0.001) and as a trait(R=-0.423,p<0.001).DiscussionPeople working in the home office mode obtained significantly higher scores for experienced stress, state and trait anxiety and depressive symptoms compared to people working in the hybrid mode, and significantly higher scores in terms of state anxiety than office workers.Conclusions1.Contact Centre employees did not differ from internal employees in terms of experienced levels of stress or symptoms of depression and anxiety.2.Working from home can increase the level of perceived stress and symptoms of depression and anxiety among employees.3.More severe depressive and anxiety symptoms and greater perceived stress are associated with a lower perceived level of job satisfaction among young adults.
Factors associated with malaria infection among children after distribution of PBO-pyrethroid synergist-treated nets and indoor residual spraying in north-western Tanzania
Authors: Kibondo Ummi Abdul , Renju Jenny , Lukole Eliud , Mosha Jacklin F. , Mosha Franklin W. , Manjurano Alphaxard , Rowland Mark , Protopopoff Natacha 
Published: December 2023

Background
After a decade of successful control, malaria is on the rise again. The prevalence of malaria in Tanzania has increased from 7% in 2017 to 8% in 2022 and reached 18% in Kagera region in the North West of Tanzania. Malaria vectors in Muleba district Kagera have high level of pyrethroid resistance. The aim of this paper is to explore factors associated with malaria infection prevalence in children aged 6 months to 14 years in Muleba, where Long Lasting Insecticidal Net (LLIN) combining a pyrethroid insecticide and synergist piperonyl butoxide (PBO) that counteract resistance in the mosquitoes, was first distributed under trial conditions in 2015.

Methods
The trial was a community randomized control in which there were two malaria prevalence cross-sectional household surveys each year (June and December) from 2015 to 2017 in Muleba. In this study we conducted a secondary data analysis of the December surveys only. Multilevel Poisson regression analysis was used to assess factors associated with malaria infection.

Results
A total of 10,941 children and 4,611 households were included in this study. Overall malaria prevalence was 35.8%, 53.3% and 54.4% in the year 2015, 2016 and 2017 respectively. Living in an area with standard LLIN as opposed to the novel PBO synergist LLIN, being a male child, above 5 years of age, living in a house with open eaves, living in house without IRS, having head of household with no formal education, lower socioeconomic status and survey year were associated with increased risk of malaria infection.

Conclusions
Using PBO LLIN reduced the risk of malaria infection. However, additional measures could further reduce malaria infection in areas of insecticide resistance such as housing improvement.