bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Co-Crystallization Technique to Improve Solubility of Anti-Diabetic Drug
Authors: Burkhande Ninad S. , Wankhade V. P. , Atram S. C. , Bobade N. N. , Pande S. D. 
Published: November 2023

Co-crystallization is a useful crystal engineering approach for changing the physiochemical and structural characteristics of drug crystals. Pharmaceutical co-crystals are nonionic supramolecular complexes that can be utilized in pharmaceutical development to change physiochemical qualities including solubility, stability, and bioavailability without changing the chemical makeup of API. Canagliflozin Hemihydrate is a anti-diabetic drug. Canagliflozin belongs to class IV drug in BCS classification. i.e. low solubility and low permeability. The major problem of this class drug is it slow solubility in biological fluids,which results into poor bioavailability after oral administration. The purpose of this study was to prepare pharmaceutical co-crystals ofCanagliflozin to enhance solubility and dissolution rate by using co-crystallization technique. The co-former used inthis study is Thiourea. The Optimized co-crystal was characterized by FTIR, XRPD, SEM and other pharmaceutical properties like solubility and melting point were alsoevaluated.
A Review for Gastro - Retentive Drug Delivery System
Authors: Patole Rutuja , Chaware Bharatee , Mohite Vishal , Redasani Vivekkumar 
Published: November 2023

Inadequate pharmacokinetic properties may be connected with the widespread use of oral dose forms in disease treatment. Because of the formulation's rapid transit through the gastrointestinal tract (GIT), it can be challenging to achieve therapeutic levels of the medicine in specific situations when it is barely soluble; In addition, some medications must work locally due to a gastric disease, although they only last a short period in the stomach. Numerous studies have been done to identify formulations that can enhance all of these characteristics while extending stomach residence time. Many orally delivered medications advantageous for from the extended stomach retention time provided by gastroretentive controlled drug delivery systems.With a focus on current methods for extending stomach residence duration, the study's objective was to examine, gather, and present the preceding and contemporary literatures in a shorter format. The current review briefly discusses the need for GRDDS., Pharmaceutical importance’s of GRDDS, Physiology of stomach, Stomach functionalities, Approaches of GRDDS, factors controlling gastric retention, advantages , disadvantages, Method of preparation of Gastro-retentive Multiparticulate system, Polymeric material in gastroretentive formulations, Evaluation of Gastroretentive dosage form, comparsion between Conventional and Gastroretentive drug delivery system.
A Review on Medicinal uses of Moringa oleifera
Authors: Dhiman Jasmine 
Published: November 2023

There are about thirteen species of Moringa trees in the family Moringaceae. Moringa oleifera Lam. (synonym: Moringa pterygosperma Gaertn.) is the most widely known species. All part of the Moringa tree is useful in some way and people depends on it for their livelihood. The leaves of the Moringa tree are an excellent source of Nutrients like Minerals, Protein and Vitamins (A and C). Moringa tree has approximately 46 antioxidants and it is one of the cheapest sources of natural anti-oxidants. Anti-oxidants supply the free atoms needed by the human body and mitigate the effect of free radicals. M. oleifera contains active compounds such as flavonoids, tannins, saponins, alkaloids, phenolics, and triterpenoids which possess antibacterial effects. Moringa leaves contains flavonoids and tannins that are thought to have anti-inflammatory effects Moringa oleifera has high mineral and protein content and has been previously investigated for its potential in treating different oral soft tissue diseases. Present review summarises the various medicinal uses of Moringa oleifera.
Keywords: Moringa oleifera, Anti-oxidants, Oral diseases, dentistry
Aprender a Língua Inglesa: um imperativo da contemporaneidade
Authors: Thomaz Rafaela , Wanderer Fernanda 
Published: November 2023

O artigo apresenta resultados de uma pesquisa que analisou os sentidos atribuídos à aprendizagem da Língua Inglesa (LI) na contemporaneidade. O corpus é formado por redações de candidatos à vaga de docente de inglês em uma instituição de ensino no RS, entre 2016 e 2018. Como aportes teóricos, recorreu-se a autores como Michel Foucault, Sylvio Gadelha e López-Ruiz, operando com os conceitos de empreendedorismo de si e Capital Humano. Os resultados apontam que: 1) os professores percebem a aprendizagem da LI como forma de transformarem seus futuros, contribuindo para uma nação desenvolvida; 2) a LI completa o aprendiz com aquilo que ele necessita para ser, estar e agir na sociedade neoliberal; 3) saber inglês é considerado indispensável para a obtenção de “grandes empregos” e cargos “melhores”. A pesquisa concluiu que a LI é uma ferramenta associada ao sucesso profissional, configurando-se, ao mesmo tempo, em forma de in/exclusão.
Altas habilidades, psicomotricidade e corporeidade: um estudo de revisão da literatura
Authors: Peixoto Maria Beatriz Campos de Lara Barbosa Marins , Capellini Vera Lúcia Messias Fialho , Rossi Fernanda 
Published: November 2023

Programas de enriquecimento curricular potencializam o desenvolvimento de estudantes com altas habilidades/superdotação (AH/SD). A psicomotricidade é uma das áreas de domínio desse público, porém pouco explorada. Relacionado a essa temática há o conceito da corporeidade - maneira pela qual o cérebro reconhece e utiliza o corpo como instrumento relacional com o mundo. Assim, este estudo objetivou mapear pesquisas e experiências em artigos científicos considerando estes dois constructos Psicomotricidade e Corporeidade combinados com educação, envolvendo a população de indivíduos com AH/SD. O método de trabalho foi o levantamento com os descritores combinados, no Portal Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Os dados encontrados demonstram que embora a Psicomotricidade seja uma das áreas de domínio combinada a outra ou não em indivíduos com AH/SD, evidências científicas ainda são insipientes. Do levantamento foram selecionados ao final quatro estudos que abrangessem os descritores educação, AH/SD e corporeidade ou psicomotricidade. A leitura e análise dos achados explicita que não existe produção de artigos no âmbito da educação sobre corporeidade ou psicomotricidade que tratem de estudantes com AH/SD e o respectivo enriquecimento, indicando a suma importância de produção em trabalhos de enriquecimento com estudantes de AH/SD nas áreas da psicomotricidade ou corporeidade.
Develando la educación híbrida post-pandémica: Perspectivas de estudiantes y profesores sobre la modalidad virtual de educación
Authors: Francisco-Pérez Judith , Venus Medina-Maldonado  , Ortiz-Francisco Gabriel , Blanco Manuel-R , Bates Benjamin-R 
Published: November 2023

Se realiza un diseño mixto paralelo-convergente para evaluar el impacto de la “pedagogía pandémica” en profesores y estudiantes. Mediante encuestas en línea y entrevistas en profundidad se identifica que la mayoría de los educadores informan una competencia media a alta en tecnología, organización y gestión de estudiantes, así como estresores relacionados con el impacto de la educación virtual en su calidad de vida. Los estudiantes experimentan fatiga física, aburrimiento, agotamiento y pasividad. Las entrevistas revelan las aspiraciones de los educadores para abordar estos desafíos, asegurar un mejor apoyo administrativo y fortalecer la gestión pedagógica. La pedagogía pandémica muestra retos para el aprendizaje y oportunidades de cambios transformadores para la educación en enfermería.
PENGEMBANGAN MODUL BIMBINGAN KELOMPOK DENGAN TEKNIK EFT (EMOTIONAL FREEDOM TECHNIQUE) UNTUK MENGATASI STRES AKADEMIK SISWA KELAS VIII SMPN 1 DARANGDAN
Authors: Fajar Amira Nur , Fatimah Siti , Ayu Ningrum Devy Sekar 
Published: November 2023

The purpose of this research is to assist students in overcoming their academic stress using a group guidance module with the EFT (Emotional Freedom Technique) technique. This research uses research and development (R&D) methods using the Borg and Gall model. The sample used in this study were 8 students of class VIII SMPN 1 Darangdan. The results showed that the product developed at SMPN 1 Darangdan, namely the development of group guidance module media with the EFT (Emotional Freedom Technique) technique to overcome students' academic stress was very feasible to use, this is in line with the results of expert practitioner validation which is 90% "Very Eligible" and the validation of student responses to the product is 97% "Very Eligible" so that the group guidance module with the EFT (Emotional Freedom Technique) technique is categorized as suitable to be used to help overcome students' academic stress.Â Keywords:Â Group, Guidance Module, EFT (Emotional Freedom Technique), academic stress
The need to introduce an electronic document turnover system at the enterprises of the military–industrial complex
Authors: Knopov B. O. 
Published: November 2023

This article discusses the need for the introduction of electronic document circulation systems at enterprises of the military–industrial complex. In modern times, the flow of documents at the enterprises of the defense–industrial complex is becoming larger, and the processing of these documents takes a lot of time, which leads to a slowdown in the process of working with documents and, accordingly, creates problems in making managerial decisions. At the enterprises of the military–industrial complex, information is provided in the form of official documents and, depending on the speed of processing these documents, the prompt transmission of information and the provision of all types of work with documents depends. That is why the article reflects all the disadvantages of paper document management and all the advantages of electronic document management.The subject of the study is the main aspects of the introduction of an electronic document management system at enterprises of the military–industrial complex.Research methods. To write the article, general scientific methods were used, such as the method of information processing, analysis, deduction, graphical and tabular methods.The article proposes two methods for the introduction of electronic document management at enterprises of the military– industrial complex, which will solve the problems of the transition of enterprises from the old paper system to a new and innovative system. It is also determined that the transition to electronic document management will speed up the process of processing documents at enterprises of the military–industrial complex.
ELIT POLITIK DAN KETERLIBANNYA DALAM PIMILUKADA DI KOLAKA UTARA
Authors: Rasyid Surayah 
Published: November 2023

Orientasi politik di kalangan elit politik dalam pemilukada setidaknya dapat dilihat pada dua hal, yaitu orientasi yang bersifat pragmatis dan yang bersifat ideologis. Orientasi pragmatis adalah dimana elit-elit politik memposisikan dirinya sebagai “elit lokal” untuk berjuang memenangkan pemilihan yang dilakukan sekali dalam lima tahunan itu. Dalam konteks ini elit-elit politik akan memaksimalkan usahanya untuk memperoleh kekuasaan karena itu yang menjadi orientasi politik. Sementara orientasi ideology, elit politik yang terjun ke gelanaggang politik merupakan panggilan hati untuk mengawal proses demokratisasi agar tercipta masyarakat yang aman, tentaram, adil dan makmur. Atau dengan bahasa agama, bagian dari amar ma’ruf nahi mungkar. Jika dilihat kedua orientasi tersebut, maka orientasi yang bersifat pragmatisme ini lebih dominan dibandingkan dengan yang bersifat ideology. Kepentingan pragmatis motivasinya bisa beragam sesuai dengan keragaman kepentingan dan orientasi elit tersebut. Dan orientasi politik di kalangan elit bisa beragam motivasinya. Motivasi itu ada yang karena ingin berkuasa, ada karena ingin mencari nafkah lewat politik, ada karena ingin mengembangkan wawasan kebangsaan, dan ada pula karena ingin terkenal. Tetapi dari hasil penelitian mnunjukan bahwa motivasi kekuasaanlah yang paling dominan dari pada yang lain.
Historiografi Islam Klasik
Authors: Kadril Muhammad 
Published: November 2023

In this research was study that focused on Islam historiography in the classical era, that was very important to be discussed and analyzed because historiography was the parent of reconstructing history hence the role of historiography was very useful as a foundation for writing historical history. In this research there were several formulations of the issues raised by the researcher about: What were the topics discussed in the early period of Islamic historiography, as well as how the development of reading Islamic historiography. This type of research was a historical study hence it can analyze Islamic historiography in the classical period in depth hence it can know the various important things in the development of historiography starting from the initial themes of its writing to the process of its development. In the research process, it certainly used several approaches including the historical approach as the main approach in this research, the religious, and social approaches. The results of this study can reveal a variety of historiographies in the classical period besides the development of Islamic historiography writing to enter the figures who had succeeded in proclaiming many writings about Islamic historiography.Penelitian ini merupakan kajian yang berfokus pada historigrafi Islam pada masa klasik, hal ini sangatlah penting untuk dibahas dan dianalisis sebab historiografi merupakan induk dari merekonstruksi sejarah sehingga peranan historiografi sangatlah berguna sebagai peletak dasar penulisan sejarah. Pada tulisan ini terdapat beberapa rumusan masalah yang telah diajukan oleh penulis diantaranya : Apa topik pembahasan pada periode awal historiografi Islam, serta Bagaimana perkembangan penulisan historiografi Islam. Jenis kajian ini merupakan kajian sejarah sehingga dapat menganalisis historiografi Islam pada masa klasik secara mendalam serta dapat mengetahui berbagai hal penting dalam perkembangan historiografi mulai dari tema-tema awal penulisannya sampai pada proses perkembangannya. Pada proses penelitiannya tentu menggunakan beberapa pendekatan diantaranya pendekatan sejarahsebagai pendekatan utama dalam tulisan ini, pendekatan agama, serta sosial. Adapun hasil penelitian ini dapat mengungkap berbagai macam historiografi pada masa klasik selain itu adapula perkembangan penulisan historiografi Islam hingga masuk pada tokoh-tokoh yang telah berhasil memproklamir banyak tulisan tentang historiografi Islam.
PERADABAN ISLAM PADA MASA DINASTI-DINASTI KECIL DI TIMUR BAGHDAD
Authors: Al Farouqy AR MIFTAH 
Published: November 2023

Abstact:This article discusses the development of Islamic civilization in the east of Baghdad. The Abbasid empire once reached the peak era of Islamic civilization. This qualitative work was written by library method, the data collected by the writter of the history books. The study yileded results tht the Abbasid victory was short-lived, the dynamic polliticall situation, coupled with the power struggle between nations the Persian-Turkish and the Sunni-Shia conflict in the east region of Baghdad. The situation gave rise to a pollitical movement that resulted in new power from the Persians who founded power in the Thahirid Dynasty (820-897 c. e.), followed by The Shaffarid Dynasty (867-908 c. e), The Samanid Dynasty (819-999 c.e.), and The Buyid Dynasty (933-1055 c.e.). From Turk came the Ghaznavid Dynasty (977-1186 c.e.), The Seljuk Dynasty (1037-1157 c.e.) and The Khwarazmian Dynasty (1077-1231 c.e.). The Caliph is only symbol of the state of the Buyid-Seljuk era, and The Abbasid Empire are divided into small states led by governors known as amir or sulthan. It also gave rise the rival cities of Baghdad as the center of world civilization, such as Isfahan, Ghaznah, Shiraz and BukharaKeywords: Abbasid, Centra Asia, Islamic Civilization, East of Baghdad Abstrak:Artikel ini membahas perkembangan peradaban Islam di Timur Baghdad. Dinasti Abbaisyah pernah mencapai era puncak peradaban Islam. Artikel yang merupakan penelitan kualitatif ini ditulis dengan metode pustaka, data dikumpulkan oleh penulis dari buku-buku sejarah. Dari penelitian ini didapatkan hasil, bahwa kejayaan Abbasiyah tidak berlangsung lama, situasi politik yang berlangsung secara dinamis, diwarnai dengan perebutan pengaruh kekuasaan antara bangsa Persia-Turki dan konflik Sunni-Syiah di wilayah timur Baghdad. Situasi ini melahirkan gerakan politik yang membuat kekuasaan baru di mulai dari bangsa Persia yang mendirikan kekuatan di Dinasti Thahiriyah (820-897 M), kemudian dilanjutkan oleh Dinasti Shaffariyah (867-908 M), Dinasti Samaniyah (819-999 M), dan Dinasti Buwaihi (933-1055). Dari bangsa Turki, berdiri Dinasti Ghaznawiyah (977-1186 M), Dinasti Seljuk (1037-1157 M) dan Dinasti Khwarizm (1077-1231 M). Khalifah hanya sebagai simbol negara di era kekuasaan Buwaihi-Seljuk, dan negara Abbasiyah terpecah belah menjadi negara-negara kecil yang dipimpin oleh para gubernur yang dikenal dengan amir atau sulthan. Selain itu, keadaan ini juga melahirkan kota-kota pesaing Baghdad sebagai pusat peradaban dunia, seperti Isfahan, Ghaznah, Syiraz dan Bukhara.Kata Kunci: Abbasiyah, Asia Tengah, Peradaban Islam, Timur Baghdad
Institusi-institusi Pendidikan dan Transmisi Ilmu: Masjid, Madrasah, dan Lembaga Pendidikan
Authors: Mahmudah Aminatul 
Published: November 2023

AbstrakTulisan ini bertujuan untuk mengetahui institusi-institusi pendidikan Islam yang muncul dan berkembang dalam membangun peradaban Islam yang maju dalam bidang keilmuan. Hal ini menjadikan institusi pendidikan Islam sebagai sarana berlangsungnya proses transmisi ilmu di dalamnya yang telah berjalan dari waktu ke waktu. Perkembangan institusi pendidikan Islam ini telah menunjukkan eksistensinya dari masa Nabi Muhammad SAW yang dimulai dari institusi pra Madrasah yakni salah satunya masjid sebagai pusat transmisi Ilmu kala itu, hingga berkembang pesat menjadi madrasah dan lembaga pendidikan Islam yang banyak bermunculan. Transmisi ilmu dalam institusi pendidikan telah membangun peradaban Islam menjadi tumbuh, berkembang dan maju seperti sekarang ini. Kata Kunci: Institusi Pendidikan Islam, Transmisi Ilmu, Masjid, Madrasah, Lembaga Pendidikan AbstractThis paper aims to find out Islamic educational institutions that have emerged and developed in building an advanced Islamic civilization in the field of science. This makes Islamic educational institutions as a means of transmitting knowledge in it which has been running from time to time. The development of this Islamic educational institution has existed since the time of the Prophet Muhammad, which began with pre-madrasa institutions, one of which was the mosque as a center for the transmission of knowledge at that time, until it developed rapidly into madrasas and Islamic.educational.institutions that have sprung up. The transmission of knowledge in educational institutions has built Islamic civilization to grow, develop and advance as it is today.
EVALUASI SISTEM KEBIJAKAN PENERIMAAN PESERTA DIDIK BARU (PPDB) BERBASIS ZONASI
Authors: Makmur Makmur 
Published: November 2023

This study discusses the evaluation of the new student admissions policy system based on zoning at the high school level in Palopo. The purpose of this study was to find out how the new student admissions policy system at the high school level in Palopo, and to find out how the implementation and social problems caused by the implementation of new student admissions based on zoning at the high school level in Palopo. The type of research used is qualitative research. Data were collected using primary data and secondary data in the form of literature studies, books, journals, magazines, newspapers, and previous research relevant to the research topic. The results of the study on new student admissions (PPDB) zoning are very good to be maintained by the government because they provide a positive value to the world of education. some positive values of PPDB zoning implementation are 1). Eliminating the term excellent and non-preferred schools. 2). There was an even distribution of students in every school 3). The Students very easy to get school because their homes are close to schools 4). Students whose IQ is not too good can study in schools with good quality education 5). Provide equal opportunities for parents to send their children to schools that have superior quality graduates. and 6). Economic Efficient.
Calculation of body surface area of corn snakes (Pantherophis guttatus) utilizing computed tomography
Authors: Hinkle Daria G. , Nelson Nathan C. , Duke Elizabeth G. , Harrison Tara M. 
Published: November 2023

Abstract

OBJECTIVE
To determine the K-constant for body surface area calculation from body weight in corn snakes (Pantherophis guttatus) through the use of computed tomography (CT) measurements.

ANIMALS
12 adult corn snakes held by North Carolina State University for research purposes underwent CT between November 2022 and January 2023.

METHODS
Each snake had a CT scan, physical examination, and body weight measurement. CT images were uploaded into software able to perform 3-D reconstruction and measure body surface area. The species-specific K-constant was determined using nonlinear regression analysis between body surface area and (body weight in grams)2/3.

RESULTS
The mean body weight of the 12 adult corn snakes was 228 g, with a mean body surface area of 505.1 cm2. The calculated K-constant was 13.6 (P < .001). The resulting formula for body surface area in corn snakes is BSA in cm2 = 13.6 X (body weight in grams)2/3.

CLINICAL RELEVANCE
The body surface area formula developed for corn snakes will allow for improved dosing accuracy for medications with low therapeutic safety margins. Additional pharmacokinetic and pharmacodynamic studies are necessary to determine the safety and efficacy of individual medications.
Machine Learning Approach for New COVID-19 Cases Using Recurrent Neural Networks and Long-Short Term Memory
Authors: Yulita Intan Nurma , Manurung David Ferdinand Imanuel , Suryana Ino 
Published: November 2023

This research aims to predict new COVID-19 cases in Bandung, Indonesia. The system implemented two types of deep learning methods to predict this. They were the recurrent neural networks (RNN) and long-short-term memory (LSTM) algorithms. The data used in this study were the numbers of confirmed COVID-19 cases in Bandung from March 2020 to December 2020. Pre-processing of the data was carried out, namely data splitting and scaling, to get optimal results. During model training, the hyperparameter tuning stage was carried out on the sequence length and the number of layers. The results showed that RNN gave a better performance. The test used the RMSE, MAE, and R2 evaluation methods, with the best numbers being 0.66975075, 0.47075, 0.29616625, and 0.7644 on the test data.