bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics and bioequivalence of sunitinib and Sutent® in Chinese healthy subjects: an open-label, randomized, crossover study
Authors: Wang Yanli , Deng Qiaohuan , Gao Zhenyue , Liu Guangwen , Su Zhengjie , Zhao Yicheng , Zhang Lixiu , Yang Haimiao 
Published: November 2023

Purpose: The purpose of this study was to examine the pharmacokinetics (PK), bioequivalence and safety of generic sunitinib and its original product Sutent® in healthy Chinese subjects through a phase-I clinical trial.Methods: The study selected two groups of 24 healthy Chinese subjects in a 1:1 ratio through random allocation. Each participant received either 12.5 mg of sunitinib or Sutent® per cycle. A total of 15 different time points were employed for blood sample collection during each cycle. Furthermore, a comprehensive assessment of the drugs’ safety was consistently maintained throughout the trial.Results: The average adjusted geometric mean ratios (GMR) (90% CI) for the primary PK parameters Cmax, AUC0-t and AUC0-∞ were 97.04% (93.06%–101.19%), 98.45% (93.27%–103.91%) and 98.22% (93.15%–103.56%), respectively. The adjusted GMRs for essential pharmacokinetic (PK) parameters all met the requirements for bioequivalence, with values within the acceptable range of 80%–125%. In addition, the two drugs showed comparable results for the other PK parameters. These results indicate that the two drugs were bioequivalent. Furthermore, both drugs showed well safety.Conclusion: The research results proved that the PK and safety profiles of sunitinib in healthy Chinese subjects were comparable to those of Sutent®. These results advocate the clinical application of generic sunitinib as a potential alternative to original product Sutent® in the treatment of certain medical conditions.
The effects of blood flow restriction training on PAP and lower limb muscle activation: a meta-analysis
Authors: Wang Jian , Liu Haiyang , Jiang Lizhu 
Published: November 2023

Objective: This study aims to systematically evaluate the effects of blood flow restriction (BFR) training on lower limb muscle activation and post-activation potentiation (PAP) in athletes through a meta-analysis and discuss methods to improve instant muscle strength so as to provide a reference for training in this field.Methods: Randomized controlled trials (RCTs) that examined the impact of BFR training on muscle activation and PAP were gathered through database searches, such as CNKI, Wanfang, Web of Science, PubMed, and others. The Cochrane risk of bias tool was used to include and exclude literature. Quality evaluation and statistical analysis were conducted using ReviewManager 5.3 software, STATA 16.0, and other software programs. The sensitivity analysis and funnel plots were employed to assess result stability and publication bias.Results: In total, 18 literature studies were included with a total of 267 subjects. The meta-analysis showed that BFR could significantly improve the RMS value of lower limb muscles [SMD = 0.98, 95% CI (0.71, 1.24), and p &lt; 0.00001]. BFR had a significant effect on the immediate explosive power of the lower limbs [SMD = 0.28, 95% CI (0.02, 0.53), and p = 0.03], but the heterogeneity was obvious (I2 = 51%). The subgroup analysis showed that different training methods may be influencing factors that lead to the heterogeneity between studies. The measurement indexes were the counter movement jump (CMJ) [SMD = 0.45, 95% CI (0.20, 0.69), and p = 0.0004], training mode to overcome body weight [SMD = 0.57, 95% CI (0.33, 0.82), and p &lt; 0.00001], and compressive strength of 40%–60% arterial occlusion pressure (AOP) [SMD = 0.57, 95% CI (0.31, 0.83), and p &lt; 0.0001], which reached the maximum effect and was statistically significant.Conclusion: BFR training can induce lower extremity muscle activation and PAP. Combining self-weight training with BFR exercises set at 40%–60% AOP appears to be particularly effective in inducing PAP, especially for enhancing CMJ. Furthermore, combining body-weight training with BFR is considered an effective warm-up method to improve CMJ.Systematic Review Registration: http://inplasy.com, identifier INPLASY2023100087
Tales of me: storytelling identity work, authenticity, and impression management during new CEOs’ work role transitions
Authors: Felix Bruno , Santos Renata dos , Teixeira Aridelmo 
Published: November 2023

IntroductionThis study aims to understand how new CEOs construct, revise, and maintain in their narrative, repertoire stories that represent their identity as it is associated with their new occupational role.MethodsFor this purpose, we conducted a qualitative study using the Grounded Theory method, involving 47 CEOs from different sectors residing in Brazil.ResultsOur results allowed for the construction of a central category called Storytelling Identity Work, which refers to stories that individuals tell about themselves, and enable them to propose and redefine who they are during major life transitions. This paper seeks to explain: (a) under what conditions this phenomenon tends to occur; (b) what characterizes the success of Storytelling Identity Work and; (c) what leads to the revision or retention of stories in the self. Our results show that storytelling identity work tends to be used by new CEOs during their transition period into the role, and when their new position involves higher levels of visibility and alteration of prestige levels in comparison to their previous position. They also suggest that storytelling identity work tends to be more successful when the stories are co-constructed and validated with other significant individuals and when they enable new CEOs to feel “sufficiently authentic” and “sufficiently impressive.” Finally, we theorize that such feelings, along with a sense of coherence between the story being told and other narratives consciously or unconsciously being narrated by the interviewees throughout their lives, lead to the retention of the story within the individual’s self.DiscussionThis article innovates by connecting the literature on personal storytelling with identity work and exploring processes that are not only useful during the process of transitioning into the role of new CEOs but also influence the constitution of the narrative repertoire and, consequently, the identity of these individuals.
Psychological characteristics of the relationship between mental health and hardiness of Ukrainians during the war
Authors: Predko Viktoriia , Schabus Manuel , Danyliuk Ivan 
Published: November 2023

ObjectivesThe aim of our survey is to identify psychological features for the relationship between mental health and hardiness of Ukrainians during the war.MethodsThe study involved 608 Ukrainians. We aimed to identify the relationship between mental health and hardiness and determine the differences in the peculiarities of mental health of people with different levels of hardiness. Also we looked for predictors for hardiness.ResultsSubjective hardiness was found to be related to specific manifestation of mental health in the Ukrainian population. Strong correlations were revealed for hardiness with adaptation (ρ = 0.818), emotional comfort (ρ = 0.786), internality (ρ = 0.672), self-perception (ρ = 0.656,), escapism (ρ = −0.632) and mental health (ρ = 0.629). A prognostic model based on linear regression analysis identified the main predictors of personal hardiness and confirmed correlational analysis. Mental health (0.341), emotional comfort (ρ = 0.786), and escapism (−0.576) were found to be good predictors. Altogether 40.1% of Ukrainians scored low, 54.6% medium, and 5.3% high on individual hardiness.ConclusionThe study found that about every 4th Ukrainian demonstrates a low level of personal hardiness, which is accompanied by emotional discomfort and lack of internal locus of control, making them more susceptible to stress and illness. Additionally, they tend to distance themselves which significantly exacerbates the situation. It has been found that Ukrainians with low levels of personal hardiness exhibit escapism (with diversion of the mind to imaginative activity), a destructive defense mechanism that not only prevents effective problem solving but also has long-term negative consequences for their overall health. Consequently, especially people with low hardiness should receive specific support to stabilize their mental wellbeing and health overall.
Motivating online language learning: exploring ideal L2 self, grit, and self-efficacy in relation to student satisfaction
Authors: Sun Zhijie , Mu Bingyu 
Published: November 2023

IntroductionThis study delves into the intricate network of motivational factors that influence online learning satisfaction among intermediate-level English as a Foreign Language (EFL) students in mainland China.MethodsA diverse sample of 496 EFL students participated in this research. Structural Equation Modeling was employed as the analytical method.ResultsThe results of the study reveal significant and positive relationships between ideal L2 self and L2 grit with online learning satisfaction. Additionally, online learning self-efficacy emerged as a crucial mediator between ideal L2 self and online learning satisfaction, as well as between L2 grit and online learning satisfaction.DiscussionThese findings provide valuable insights into the motivational dynamics within online language learning contexts. They offer practical implications for educators and instructional designers seeking to enhance students’ online learning experiences.
Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine
Authors: Loftis Jennifer M. , Ramani Sankrith , Firsick Evan J. , Hudson Rebekah , Le-Cook Anh , Murnane Kevin S. , Vandenbark Arthur , Shirley Renee L. 
Published: November 2023

IntroductionCurrently, there are no FDA-approved medications to treat methamphetamine addiction, including the inflammatory, neurotoxic, and adverse neuropsychiatric effects. We have shown that partial (p)MHC class II constructs (i.e., Recombinant T-cell receptor Ligand – RTL1000), comprised of the extracellular α1 and β1 domains of MHC class II molecules linked covalently to myelin oligodendrocyte glycoprotein (MOG)-35-55 peptide, can address the neuroimmune effects of methamphetamine addiction through its ability to bind to and down-regulate CD74 expression, block macrophage migration inhibitory factor (MIF) signaling, and reduce levels of pro-inflammatory chemokine ligand 2 (CCL2). The present study evaluated the effects of our third-generation pMHC II construct, DRmQ, on cognitive function and concentration of inflammatory cytokines in the frontal cortex, a region critical for cognitive functions such as memory, impulse control, and problem solving.MethodsFemale and male C57BL/6J mice were exposed to methamphetamine (or saline) via subcutaneous (s.c.) injections administered four times per day every other day for 14 days. Following methamphetamine exposure, mice received immunotherapy (DRmQ or ibudilast) or vehicle s.c. injections daily for five days. Cognitive function was assessed using the novel object recognition test (NORT). To evaluate the effects of immunotherapy on inflammation in the frontal cortex, multiplex immunoassays were conducted. ANOVA was used to compare exploration times on the NORT and immune factor concentrations.ResultsPost hoc analysis revealed increased novel object exploration time in MA-DRmQ treated mice, as compared to MA-VEH treated mice (non-significant trend). One-way ANOVA detected a significant difference across the groups in the concentration of macrophage inflammatory protein-2 (MIP-2) (p = 0.03). Post hoc tests indicated that mice treated with methamphetamine and DRmQ or ibudilast had significantly lower levels of MIP-2 in frontal cortex, as compared to mice treated with methamphetamine and vehicle (p &gt; 0.05).DiscussionBy specifically targeting CD74, our DRQ constructs can block the signaling of MIF, inhibiting the downstream signaling and pro-inflammatory effects that contribute to and perpetuate methamphetamine addiction.
Implementation of structured feedback in a psychiatry residency program in Canada: a qualitative analysis study
Authors: Thakur Anupam , Darani Shaheen , Kalocsai Csilla , Silver Ivan , Sockalingam Sanjeev , Soklaridis Sophie 
Published: November 2023

IntroductionStructured feedback is important to support learner progression in competency-based medical education (CBME). R2C2 is an evidence-based four-phased feedback model that has been studied in a range of learner contexts; however, data on factors influencing implementation of this model are lacking. This pilot study describes implementation of the R2C2 model in a psychiatry CBME residency program, using the Consolidated Framework for Implementation Research (CFIR).MethodsThe study was carried out in three phases: planning, implementation and evaluation. After receiving training, 15 supervisors used the R2C2 feedback model with residents. Semi-structured interviews explored (n = 10) supervisors’ experience of the model. CFIR was used to identify factors that influence implementation of the R2C2 model when providing feedback to residents.ResultsQualitative data analysis revealed four key themes: Perceptions about the R2C2 model, Facilitators and barriers to its implementation, Fidelity to R2C2 model and Intersectionality related to the feedback. The CFIR implementation domains provided structure to the themes and subthemes.ConclusionThe R2C2 model is a helpful tool to provide structured feedback. Structure of the model, self-efficacy, in-house educational expertise, learning culture, organizational readiness, and training support are important facilitators of implementation. Further studies are needed to explore the learner’s perspective and fidelity of this model.
Self-stigmatization of high-school students seeking professional psychological help: the chain-mediating effect of perceived social support and optimism
Authors: Bu Nanyin , Li Zuoshan , Jiang Jiarui , Chen Xin , Li Ziying , Xiao Yujuan , Wang Xueyan , Zhao Tianyi 
Published: November 2023

BackgroundResearch has shown that stigmatization of professional psychological help-seeking is an important factor influencing attitudes toward seeking professional psychological help (ATSPPH). However, how perceived social support (PSS) and optimism have a mediating role is not clear.ObjectiveExamine the associations between ATSPPH, self-stigmatization of seeking help, PSS, and optimism in a cohort of Chinese high-school students (HSSs).MethodsAn offline survey was conducted in three high schools in Chongqing (China) from 20 February to 20 May 2023. Participants were HSSs recruited through their teachers. A total of 2,159 HSSs completed a survey on demographic information as well as the Self-Stigmatization of Seeking Help (SSOSH) score, ATSPPH, Perceived Social Support Scale (PASS), and Life Orientation Test (LOT). Mediation analyses were conducted using the “Process” macro in SPSS 26.0 to estimate the direct and indirect effects of self-stigmatization of seeking psychological help on ATSPPH.ResultsSelf-stigmatization of seeking psychological help was significantly and negatively related to ATSPPH among HSSs. Self-stigmatization of psychological help-seeking influenced ATSPPH through three pathways: (a) separate mediating effect of PSS (effect = −0.029); (b) separate mediating effect of optimism (effect = −0.069); (c) chain-mediating effect of PSS and optimism (effect = −0.017). These data suggested that self-stigmatization of psychological help-seeking could influence ATSPPH directly and indirectly through PSS and optimism.ConclusionPSS and optimism mediated the relationship between self-stigmatization of seeking help and ATSPPH. Improving the ability of HSSs to perceive social support and cultivating optimism could help improve the self-stigmatization of help-seeking and promote a positive attitude toward professional help-seeking.
Knowledge, attitudes, and practices toward over-the-counter antipyretics among fever patients: a cross-sectional study in the context of a policy change KAP of OTC antipyretics
Authors: Zhang Yan , Liang Shuchang , Zhu Tao 
Published: November 2023

BackgroundOn January 8, 2023, a change in the control policy for COVID-19 was implemented in China, whereby patient self-management of fever typically entails the utilization of over-the-counter fever-reducing medications.ObjectiveThis study aimed to investigate the knowledge, attitudes, and practices (KAP) toward over-the-counter (OTC) antipyretics among fever patients.MethodsThis cross-sectional study was conducted between October 2022 and February 2023 at author’s hospital in Wuhan, China, among fever patients on OTC antipyretics, using a self-administered questionnaire.ResultsA total of 481 valid questionnaires were collected, with the age of 36.05 ± 12.10 years, including 240 (49.90%) males, and 209 (43.45%) collected before policy change. The knowledge, attitudes, precautions for medication administration and decision-making practices scores were 6.86 ± 3.30 (possible range: 0–12), 16.67 ± 2.46 (possible range: 7–35), 29.98 ± 5.41 (possible range: 7–35) and 27.87 ± 1.28 (possible range: 8–40), respectively. The multivariable logistic regression analysis showed that knowledge (OR = 0.83, 95%CI: 0.81–0.92, p &lt; 0.001) was independently associated with positive attitude. Knowledge (OR = 1.41, 95%CI: 1.28–1.56, p &lt; 0.001), attitude (OR = 0.87, 95%CI: 0.79–0.95, p = 0.004), suburban (OR = 0.45, 95%CI: 0.23–0.88, p = 0.019) were independently associated with proactive precautions for medication administration practices. Knowledge (OR = 1.14, 95%CI: 1.07–1.22, p &lt; 0.001), attitude (OR = 0.90, 95%CI: 0.82–0.98, p = 0.018), responding after policy change, 2023 (OR = 1.70, 95%CI: 1.10–2.63, p = 0.016) were independently associated with proactive decision making practices.ConclusionFever patients had moderate knowledge, negative attitude, proactive precautions for medication administration practices, moderate decision-making practices. After the policy change, there was a significant increase in knowledge regarding medication administration precautions and decision-making.
Dispersive propagation of nuclear electromagnetic pulse in the ionosphere
Authors: Wei Yongli , Zhu Dinghan , Li Zongxiang , Wang Lihua , Wang Yuan , Zhang Tianchi , Xing Bin , Cao Baofeng , Li Peng 
Published: November 2023

Introduction: On the propagation path to the satellite, the ionosphere will distort the nuclear electromagnetic pulse (NEMP) and change its physical properties.Methods: This paper proposes a method for calculating the propagation of NEMP to the satellite. The method decomposes NEMP into the superposition of simple harmonic waves, and each simple harmonic wave is calculated separately in the ionosphere. With the consideration of different time of arrival and critical frequency of the ionosphere, the NEMP after propagating in the ionosphere is obtained by superposition of simple harmonic waves in time domain rather than the inverse Fourier transform which will erase the time domain information.Results: The results show that NEMP is dispersive in ionosphere with the pulse broadened, the speeds changed and the bandwidth narrowed. The time-frequency spectrum can provide the frequency band where the signal energy is located.Discussion: Our proposed method provides a simple and effective way to calculate the NEMP propagation in the ionosphere, which should afford help to the design of NEMP receivers and the selection of satellite orbit altitude.
Conditional performance factors in padel players: a mini review
Authors: Guijarro-Herencia J. , Mainer-Pardos E. , Gadea-Uribarri H. , Roso-Moliner A. , Lozano D. 
Published: November 2023

IntroductionPadel's global growth highlights its technical complexity. The first publications focus on the physical aspects of padel, using methods that evaluate players’ endurance, strength, speed, and range of motion, while the quantification of load, using internal and external indicators, is crucial for performance optimization, whilst taking into account athletes’ profiles and levels. Therefore, the objective entailed analyzing the scientific literature about the conditional demands in competition within padel players from different levels.MethodsData was collected from various databases and after the selection process, the information was analyzed in mini review.ResultsThe mini review shows that the conditional demands are categorized into internal and external load to try to obtain reference values that may define the demands of padel based on the competitive level and sex. Regarding the internal load, the heart rate (HR)% of the padel players from different levels is around 70%–80% of the HR Max. Regarding the external load, in femalés categories, a greater number of strokes are made per point which entails a longer duration in the points.ConclusionsPadel research usually analyses physical demands using internal and external loading. HR% values (70%–80% HR Max) are consistent across studies. There is variation between variables such as strokes per point, and contextual factors affect the metrics. Further exploration is vital to obtain comprehensive benchmarks and understand the demands of this sport.
The value of “diaphragmatic relaxing incision” for the durability of the crural repair in patients with paraesophageal hernia: a double blind randomized clinical trial
Authors: Tsoposidis A. , Thorell A. , Axelsson H. , Reuterwall Hansson M. , Lundell L. , Wallenius V. , Kostic S. , Håkanson B. 
Published: November 2023

BackgroundSurgical repair of paraesophageal hernias (PEHs) is burdened with high recurrence rates, and hitherto various techniques explored to enforce the traditional crural repair have not been successful. The hiatal reconstruction in PEH is exposed to significant tension, which may be minimized by adding a diaphragmatic relaxing incision to enhance the durability of the crural repair.Patients and methodsAll individuals undergoing elective laparoscopic repair of a large PEH, irrespective of age, were considered eligible. PEHs were classified into types II–IV. The preoperative work-up program included multidetector computed tomography and symptom assessment questionnaires, which will be repeated during the postoperative follow-up. Patients were randomly divided into a control group with crural repair alone and an intervention group with the addition of a left-sided diaphragmatic relaxing incision at the edge of the upper pole of the spleen. The diaphragmatic defect was then covered by a synthetic mesh.ResultsThe primary endpoint of this trial was the rate of anatomical PEH recurrence at 1 year. Secondary endpoints included symptomatic gastroesophageal reflux disease, dysphagia, odynophagia, gas bloat, regurgitation, chest pain, abdominal pain, nausea, vomiting, postprandial pain, cardiovascular and pulmonary symptoms, and patient satisfaction in the immediate postoperative course (3 months) and at 1 year. Postoperative complications, morbidity, and disease burden were recorded for each patient. This was a double-blind study, meaning that the operation report was filed in a locked archive to keep the patient, staff, and clinical assessors blinded to the study group allocation. Blinding must not be broken during the follow-up unless required by any emergencies in the clinical management of the patient. Likewise, the patients must not be informed about the details of the operation.Trial RegistrationClinicalTrials.gov, identification number NCT04179578.