bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Approach to Define and Quantify Porosity System in Heterogeneous Carbonate Reservoirs through Textural Analysis using High-Resolution Resistivity Image in the Bassein Formation of Mumbai Offshore Basin, India
Authors: Kumar Suraj , Panda Soumya Chandan 
Published: November 2023

Summary
In evaluating the porosity system of the Bassein formation, high-resolution resistivity image (FMI) data have been used. Major features observed from the FMI data are the presence of low-angle fractures and solution channels of varying length and thickness. Against the layers with very-low-density neutron porosity, solution channels are seen as conductive features. These mud-filled solution channels can actively participate in production. Being very small-scale features, these types of porosities are not identifiable from conventional log data. To define and quantify porosity types such as vugs, solution channel, and matrix porosity, the resistivity image data are processed and image-based porosity is calculated. A core thin-section study is carried out and is used for calibration of the image-derived porosity system. Using resistivity image data, we have computed porosity types, for example, vugs, connected matrix and resistive, and their contribution to total porosity. Identification of hydrocarbons in reservoir layers with their porosity contribution (porosity partitioning) gives better insight into hydrocarbon production in these low-porosity layers which are producing after acid job.
Memory Consolidation with Orthogonal Gradients for avoiding Catastrophic Forgetting
Authors: Kanagamani Tamizharasan , Krishnamurthy Rupak , Chakravarthy Srinivasa , Ravindran Balaraman , Menon Ramshekhar N 
Published: November 2023

Abstract
The memory consolidation process enables the accumulation of recent and remote memories in the long-term memory store. In general, the deep network models of memory suffer from forgetting old information while learning new information, called catastrophic forgetting/interference, while the human brain overcomes this problem quite effectively. We propose a regularization-based model to solve the problem of catastrophic forgetting. According to the proposed method, the network parameters are constrained to vary in a direction orthogonal to the average error gradients corresponding to the previous tasks. We also ensure that the constraint used in parameter updating satisfies the locality principle. The proposed model’s performance is evaluated by comparing it with Elastic Weight Consolidation under various conditions, from simple to complex datasets and network architectures. The proposed model gives a new view of plasticity at the neuronal level. In the proposed model, the parameter updating is controlled by the neuronal level plasticity rather than synapse level plasticity as in other standard models. The biological plausibility of the proposed model is discussed by linking the extra parameters to synaptic tagging, which represents the state of the synapse involved in Long Term Potentiation.
Greedy Knot Selection Algorithm for Restricted Cubic Spline Regression
Authors: Arnes Jo Inge , Hapfelmeier Alexander , Horsch Alexander , Braaten Tonje 
Published: November 2023

Abstract
Non-linear regression modeling is common in many fields for prediction purposes or estimating
relationships between predictor and response variables. For example, restricted cubic spline
regression can model non-linear relationships as third-order polynomials joined at knot points.
The standard approach is to place knots by a regular sequence of quantiles between the outer
boundaries. A regression curve can easily be fitted to the sample using a relatively high number
of knots. The problem is then overfitting, where a regression model has a good fit to the
given sample but does not generalize well to other samples. A low knot count is therefore preferred.
However, the standard knot selection process can lead to underperformance in the sparser
regions of the predictor variable, especially when using a low number of knots. It can also
lead to overfitting in the denser regions. We present a simple greedy search algorithm using
a backward method for knot selection that shows reduced prediction error and Bayesian information
criterion (BIC) scores compared to the standard knot selection process in simulation
experiments. We have implemented the algorithm as part of an open-source R-package, knutar.
Agro Byproduct Feedstuff as a Substitute for Conventional Feed for Rabbits in Trinidad, West Indies
Authors: Patterson Destini Aaliyah , Jones Kegan Romelle 
Published: November 2023

Abstract
This research aimed to compare the digestibility of conventional pelleted feed (Diet 1) and an agriculture by-product feed (Diet 2) made from local agricultural by products (cocoa husk shells, coconut seed meal, Moruga hill rice hulls, Moruga hill rice bran and rejected powdered beans) in 12 cross bred New Zealand rabbits reared in the humid tropical environment. The study found significant differences (p<0.05) in nutritive components between the two diets in terms of crude protein (Diet 1:150.8 g/kg vs Diet 2:113.4 g/kg), organic matter (Diet 1: 915.9 g/kg vs Diet 2: 910.8 g/kg), and ether extract (Diet 1: 2.04 g/kg vs Diet 2: 1.05 g/kg). Additionally, it was found that there were significant differences (p<0.05) in digestibility of crude protein (Diet 1:767.4g/kg vs Diet 2: 913.1 g/kg), organic matter (Diet 1: 918.9g/kg vs Diet 2: 843.6g/kg), and dry matter (Diet 1: 865.9 g/kg vs Diet 2: 793.3 g/kg). Overall, these findings suggest that Diet 2 may be a more digestible alternative to conventional pelleted feeds for rabbit with respect to crude protein, and further research may be needed to explore its potential as a viable feed source for rabbits. The findings suggest that the by-product feed can be a valuable alternative to conventional pelleted feed in rabbit production, providing cost savings and potential environmental benefits.
Impacts of sea salt ions on hydration of sulphoaluminate cement
Authors: Guo Yaowen , ZHANG Yvxuan , Wang Chuanlin 
Published: November 2023

Abstract
This study set out to investigate the influence of SO42−, Cl−, and Mg2+ on the hydration of sulphoaluminate cement by preparing a sulphoaluminate cement (CSA) paste using sea salt ion solutions with various concentrations as mixing water. The testing program included porosity, compressive/flexural strength, the heat of hydration, pH of pore solution, XRD, and SEM analysis. Ordinary Portland cement (10%) was added to increase the pH of the CSA hydration environment and improve the stability of ettringite and provide more C-S-H gel to observe the formation of M-S-H and other substances. Results demonstrated that the hydration of CSA is accelerated by Cl−, which increased the heat of hydration. And Cl− reduced the length-to-diameter ratio of ettringite that caused cracking of the CSA test block. The addition of SO42− led to a higher internal alkalinity, which change the type of hydration products and then decreased the strength of CSA. Mg2+ was found to improve the microstructure of the CSA test block, reducing its porosity and increasing its strength.
Identifying health and healthcare priorities in rural areas - a concept mapping study informed by consumers, health professionals and researchers
Authors: Shee Anna Wong , Donaldson Alex , Clapham Renee , Aitken John , Ananthapavan Jaithri , Ugalde Anna , Versace Vincent , Namara Kevin Mc 
Published: November 2023

Abstract

Background
It is vital that health service delivery and health interventions address patients’ needs or preferences, are relevant for practice, and can be implemented. Involving those who will use or deliver healthcare, in priority-setting can lead to health service delivery and research that is more meaningful and impactful. This is particularly crucial in rural communities, where limited resources and disparities in healthcare and health outcomes are often more pronounced. The aim of this study was to determine the health and healthcare priorities in rural communities using a region-wide community engagement approach.
Methods
This multi-methods study was conducted in five rural communities in the Grampians region, Western Victoria, Australia. It involved two phases: (1) surveys and community forums to identify important health issues, and stakeholder consultations with consumers and health professionals to identify values considered important for determining priorities; and (2) an innovative online group concept mapping process, involving consumers, health professionals and researchers, organising (sorting) and rating issues using the priority setting criteria from phase 1.
Results
Overall, 117 community members and 70 health professionals identified 400 health and healthcare issues. Six stakeholder consultation sessions (with 16 community members and 16 health professionals) identified three key values for prioritising health issues: equal access for equal need; effectiveness; and impact (number of people affected). Actionable priorities for healthcare delivery were largely related to access issues, such as the challenges navigating the healthcare system, particularly for people with mental health issues; the lack of sufficient general practitioners and other health providers; the high travel costs, and poor internet coverage often impacting technology-based interventions for people in rural areas.
Conclusions
This study identified actionable health and healthcare priorities from the perspective of healthcare service users and providers in rural communities in Western Victoria. Issues related to access, such as the inequities in healthcare costs, the perceived lack of quality and availability of services, particularly in mental health and disability,were identified as priorities. These insights can guide future research, policy-making, and resource allocation efforts to improve healthcare access, quality, and equity in rural communities.
Safety and Efficacy of CAPOX Combined with Bevacizumab plus Pembrolizumab as Neoadjuvant Treatment of pMMR/MSS Type Locally Advanced Colorectal Cancer Patients: Study Protocol for a Single-arm, Phase Ib, Prospective Trial (COBP)
Authors: Wang Anqi , Zhang Peng , Yu Dan , Zhu Huanhuan , Lu Shengdong , Lyu Yangbo , Hu Zongju , Ruan Canping , Wang Yi , Gao Wenchao , Zhang Jian , Zhou Haiyang 
Published: November 2023

Abstract
Background: Different from microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) colorectal cancer (CRC), almost 95% of CRC patients are microsatellite stable (MSS) which have been referred to as “cold” tumors showing primary resistance to immune checkpoint inhibitor (ICI). Pre-clinical research has elucidated the synergistic effect of ICI and anti-vascular therapy. Normalization of tumor blood vessels can improve immunotherapy. Moreover, chemotherapy has a pro-apoptotic effect on vascular endothelium to enhance the effect of promoting normalization of tumor blood vessels which can in turn promote tumor delivery of specific T cells and chemotherapy drugs into tumor tissue. Based on this, we plan to investigate the safety and efficacy of CAPOX combined with Bevacizumab plus Pembrolizumab (COBP) as neoadjuvant treatment of mismatch repair-proficient (pMMR) or MSS type locally advanced CRC patients.
Methods: This is a prospective, single-center, single-arm, phase Ib study, mainly including patients with pMMR/MSS type locally advanced CRC, to explore the safety and feasibility of pembrolizumab combined with bevacizumab and CAPOX regime. Capecitabine will be administered orally at a dose of 1000 mg/m2 twice daily from days 1 to 14, every 3 weeks. Oxaliplatin, bevacizumab, and pembrolizumab will be given intravenously at a dose of 135 mg/kg, 7.5 mg/kg, and 200 mg respectively on day 1, every 3 weeks. After 4 cycles of treatment, patients will receive CAPOX for another one cycle. After neoadjuvant therapy, radical surgery will be performed for patients operable. The primary endpoints include adverse effects, R0 resection rate, pathologic complete response rate, and tumor regression grade. The second endpoints include 1/2/3-year disease-free survival, 1/2/3-year overall survival, and quality of life.
Discussion: The COBP study is a single center phase Ib study, which aims to initially explore the safety and preliminary effectiveness of COBP regime in locally advanced CRC patients. We hope that the results of this study can provide a direction for future exploration and further improve the outcome of patients.
Trial registration: ClinicalTrials.gov NCT05585814. Registered on October 19, 2022.
Polyethyleneimine facilitates the growth and electrophysiological characterization of motor neurons
Authors: yang meimei , You Daofeng , Liu Gang , Lu Yin , Yang Guangming , O'Brien Timothy , Henshall David C , Hardiman Orla , Liu Min , Shen Sanbing 
Published: November 2023

Abstract
Background
Induced pluripotent stem cell (iPSC) technology, in combination with electrophysiological characterization via multielectrode array (MEA), has facilitated the utilization of iPSC-derived motor neurons (MNs) as highly valuable models for underpinning pathogenic mechanisms and developing novel therapeutic interventions for motor neuron diseases (MNDs). However, the challenge of adherence of MNs to MEA plates and the heterogeneity presented in iPSC-derived cultures raise concerns about the reliability of the findings obtained from these cellular models.
Methods
Human iPSCs were differentiated into MNs using an existing and our own novel protocols, and MNs were cultured on dishes coated with different coating conditions, including. POL (20µg/ml Poly-L-ornithine and 20µg/ml Laminin), POLF (20µg/ml Poly-L-ornithine, 20µg/ml Laminin and 10µg/ml Fibronectin), POLFM (20µg/ml Poly-L-ornithine, 20µg/ml Laminin, 10µg/ml Fibronectin and 1:20 Matrigel), POM (20µg/ml Poly-L-ornithine and 1:50 Matrigel), and PEI (0.1% Polyethyleneimine in borate buffer). We comparatively evaluated cell morphology, aggregation status and electrophysiological activities by MEA.
Results
We discovered that one factor modulating the electrophysiological activity of iPSC MNs is the extracellular matrix (ECM) used in coating to support the in vitro growth, differentiation and maturation of iPSC-derived MNs. We showed that two coating conditions, namely, POM and PEI strongly promoted attachment of iPSC-derived sMNs on MEA culture dishes compared to the other three conditions, and both facilitated the maturation of iPSC-derived sMNs as characterized by the detection of extensive electrophysiological activities from the MEA plates. POM coating accelerated the maturation of the iPSC-MNs for up to 5 weeks, which facilitates the modeling of neurodevelopmental disorders. However, the application of PEI resulted in more even distribution of the MNs on the culture dish and reduced variability of electrophysiological signals from the iPSC-sMNs in 7-week cultures, which permitted the detection of enhanced excitability in iPSC-derived sMNs from patients with amyotrophic lateral sclerosis (ALS).
Conclusion
This study provides a comprehensive comparison of five coating conditions and offers POM and PEI as favorable coatings for in vitro modeling of neurodevelopmental and neurodegenerative disorders, respectively.
Leaf-Inspired Asymmetrically Hierarchical Architecture Engineered Full-Paper Integrated Tactile Array for Ultra-Stable Sensory Augmentation
Authors: Yang Jun , hao sanwei , Wang Wenqi , Ma Chao , Li Xin , Liu Xidie , Wang Yicong , Xue Zhimin , Xu Feng 
Published: November 2023

Abstract

Facing the interwoven tendency of transformative advance and eco-friendly concept in wearable electronics, the development of sustainable epidermal sensor is still plagued by successfully introducing natural materials coupling with the improvement of fatigue threshold in high-frequency sensing scenarios. Here we propose a biomimetic concept that engineers a biodegradable and biocompatible full-paper integrated tactile array (FPTA) with leaf-inspired asymmetrically hierarchical architecture (LAHA) to alleviate the notorious structural vulnerability. Compared with conventional bulky configuration, the LAHA leverages compact laminated adjacent layer that dramatically facilitates in-plane stress distribution and diminishes the interfacial stress concentration for affording stable sensory augmentation, as unveiled by finite element simulation. The assembled multichannel and wireless FPTA monitoring system offers impeccable real-time spatiotemporal haptic pattern on multi-user interfaces with a record-high durability (150, 000 cycles), together with unprecedented merits integration including remarkably channel uniformity (97.2%), low interfacial contact impedance (1.78 ± 0.4 ohm, 1 kHz), and unparalleled sensitivity (12944 kPa−1), which serves as an eco-and user-friendly surveillance platform to analyze individual behavior in daily, thus suggesting a trustworthy architecture engineering strategy for tactile electronics in continuous health surveillance.
The Multidrug Resistance Protein OsMDR4 is Involved in Cadmium Absorption in Rice (Oryza sativa L.)
Authors: Xie Zijing , Hao Xiaohua , Zhao Dan , Lei Han , Jin Xinzhou , Wu Sha , Hu Wenli , Tian Lianfu , Li Dongping 
Published: November 2023

Abstract
Key message OsMDR4 is an ABC transporter which localized to plasma membrane and mainly expressed in root to mediate the Cd absorption in rice.
Abstract Cadmium(Cd) is one of heavy metals which threaten crop security production. The transporters in root are key factors involved in metal absorption. However, there are a large amount of Cd transporter in rice root remains uncharted. Here, we report a member of multidrug resistance protein OsMDR4 mediating the Cd absorption in rice. Heterologous overexpressing OsMDR4 in yeast increased the sensitivity to Cd treatment and Cd content in the cells. Consistantly, the Cd concentration of the mdr4 mutants is lower than that in wild type, in both root and shoot. In addition, the Vmax values of Cd uptake in mdr4 mutants are much lower than that of wild type by uptake kinetics analysis. OsMDR4 is mainly expressed in epidermis and root hairs of rice roots during seedling stage, and flower organs at flowering stage. Further more, the expression level of OsMDR4 in seedling root is induced by Cd supply. As a transporter OsMDR4 is localized to plasma membrane of rice cells. Taken together, we characterized a novel Cd transporter OsMDR4 which had a significant contribution in Cd influx into root.
Risk factors for delayed extubation after pediatric perineal anaplasty in patients less than 1 Year of Age: a retrospective study
Authors: Zhang Qianqian , Xu Jing , Huang Qinghua , Gong Tianqing , Li Jia , Cui Yu 
Published: November 2023

Abstract

Background Anorectal malformation is a common congenital problem occurring in 1 in 5,000 births and has a spectrum of anatomical presentations, requiring individualized surgical treatments for normal growth. Delayed extubation or reintubation may result in a longer intensive care unit (ICU) stay and hospital stay, increased mortality, prolonged duration of mechanical ventilation, increased tracheostomy rate, and higher hospital costs. Extensive studies have focused on the role of risk factors in early extubation during major infant surgery such as Cardiac surgery, neurosurgery,and liver surgery. However, no study has mentioned the influencing factors of delayed extubation in neonates and infants undergoing anoplasty surgery.
Materials and Methods We performed a retrospective study of neonates and infants who underwent anorectal malformation surgery between June 2018 and June 2022. The principal goal of this study was to observe the incidence of delayed extubation in pediatric anorectal malformation surgery. The secondary goals were to identify the factors associated with delayed extubation in these infants.
Results We collected data describing 123 patients who had anorectal malformations from 2019 to 2022. It showsthat 74(60.2%) in the normal intubation group and 49(39.8%) in the longer extubation. In the final model, anesthesia methods were independently associated with delayed extubation (P<0.05).
Conclusion We found that anesthesia method was independently associated with early extubation in neonates and infants who accepted pediatric anorectal malformation surgery.
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α
Authors: Meng Kun , Shi Liuliu , Fang Xianglan , Du Lijie , Xue Juan , Yang Jin , Hui Yuanjian 
Published: November 2023

Abstract

Accumulating studies have shown that E3 ligases play crucial roles in regulating cellular biological processes and signaling pathways during carcinogenesis via ubiquitination. Tripartite-motif (TRIM) ubiquitin E3 ligases consist of over 70 members. However, the clinical significance and their contributions to tumorigenesis remain largely unknown. In this study, we analyzed the RNA-sequencing expression of TRIM E3 ligases in colorectal cancer (CRC) and identified 10 differentially expressed genes, among which TRIM1 expression predicted poor prognosis of CRC patients. We demonstrated that TRIM1 expression is positively associated with CRC pathological stages, and higher expression is positively correlated with infiltrating levels of immune cells and immunotherapy biomarkers. TRIM1 expression promotes the proliferation and migration of colorectal cancer cells. Transcriptional analysis showed that TRIM1 is responsible for metabolism promotion and immune suppression. Mechanistically, we found that TRIM1 binds HIF1α and mediates its K63-linked ubiquitination, which is required for HIF-1α nuclear translocation and subsequent activation. Our results indicate TRIM1’s role in predicting prognosis and immunotherapy efficacy and reveal how TRIM1 functions to upregulate HIF-1α expression and promote tumor cell proliferation.
Molecular Analysis of the AGXT Gene Detected a Missense and Pathogenic Variant Associated with Primary Hyperoxaluria Type 1; a Case Study
Authors: saba nusrat , Khan Zahra , Rehman Sadia , Khan Fariha , Munir Saeeda 
Published: November 2023

Abstract
Background
Primary Hyperoxaluria Type 1 (PH1) is an autosomal recessive genetic disorder triggered by a mutation in the alanine glyoxylate aminotransferase (AGXT) gene. Early detection of PH1 is a pre-requisite as it causes End Stage Renal Disease (ESRD) in most patients in the early stages.
An eleven years old girl with a history of kidney disease and stones and with phenotypic characteristics of PH1 was brought to the laboratory. A c.568G>A mutation in AGXT gene, which is responsible for PH1, is found in a homozygous condition. Further study revealed the detection of the mutation in heterozygous form in both the parents. This study provides insight to generate more reliable genetic markers for the early detection of PH1 in a family or a population. This can lead to better and earlier treatment strategies.
Case Presentation
This study aimed to detect the AGXT gene mutationswhich are responsible for primary hyperoxaluriain the patient.AGXT gene screening was done in her parents for identifying the root cause and zygosity of the mutation. The AGXT gene on chromosome2q37.3was amplified via polymerase chain reaction and sequenced by Sanger sequencing. Molecular modeling and genetic change analysis was performed by using in-silico parameters.
Conclusion
The sequence analysis revealed the presence of a missense and pathogenic variant in the homozygous condition in the AGXT gene exon 5;c.568G>A with protein change p. Gly190Arg in the patient. Parental screening showed that the patient received one allele from her father and the other from her mother. A liver transplant followed by a kidney transplant was carried out in the patient with 6 months difference. The study emphasized that as theb mutation p.Gly190Arg is reported as a cause of PH1, this mutation can be considered an early diagnostic marker for PH1.