bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online adaptive radiotherapy for bladder cancer using a simultaneous integrated boost and fiducial markers
Authors: Azzarouali Sana , Goudschaal Karin , Visser Jorrit , Hulshof Maarten , Admiraal Marjan , van Wieringen Niek , Nieuwenhuijzen Jakko , Wiersma Jan , Daniëls Laurien , den Boer Duncan , Bel Arjan 
Published: October 2023

Abstract
Purpose
The aim was to assess the feasibility of online adaptive radiotherapy (oART) for bladder cancer using a focal boost by focusing on the quality of the online treatment plan and automatic target delineation, duration of the workflow and performance in the presence of fiducial markers for tumor bed localization.

Methods
Fifteen patients with muscle invasive bladder cancer received daily oART with Cone Beam CT (CBCT), artificial intelligence (AI)-assisted automatic delineation of the daily anatomy and online plan reoptimization. The bladder and pelvic lymph nodes received a total dose of 40 Gy in 20 fractions, the tumor received an additional simultaneously integrated boost (SIB) of 15 Gy. The dose distribution of the reference plan was calculated for the daily anatomy, i.e. the scheduled plan. Simultaneously, a reoptimization of the plan was performed i.e. the adaptive plan. The target coverage and V95% outside the target were evaluated for both plans. The need for manual adjustments of the GTV delineation, the duration of the workflow and the influence of fiducial markers were assessed.

Results
All 300 adaptive plans met the requirement of the CTV-coverage V95%≥98% for both the boost (55 Gy) and elective volume (40 Gy). For the scheduled plans the CTV-coverage was 53.5% and 98.5%, respectively. Significantly less tissue outside the targets received 55 Gy in case of the adaptive plans as compared to the scheduled plans. Manual corrections of the GTV were performed in 67% of the sessions. In 96% of these corrections the GTV was enlarged and resulted in a median improvement of 1% for the target coverage. The median on-couch time was 22 min. A third of the session time consisted of reoptimization of the treatment plan. Fiducial markers were visible on the CBCTs and aided the tumor localization.

Conclusions
AI-driven CBCT-guided oART aided by fiducial markers is feasible for bladder cancer radiotherapy treatment including a SIB. The quality of the adaptive plans met the clinical requirements and fiducial markers were visible enabling consistent daily tumor localization. Improved automatic delineation to lower the need for manual corrections and faster reoptimization would result in shorter session time.
Exploring the structure of the shot effectiveness model for elite table tennis players
Authors: Yang Qing , Li Mu-zi , Zhou Zheng , Zhang Hui 
Published: October 2023

Abstract
Background
Currently, technical and tactical analysis has become an indispensable task for sport in many countries. Many studies analysed players’ specific technical and tactical factors, but it is rare to quantitatively analyse the importance of table tennis players’ shot effectiveness. This is the first study to propose the new concept of “shot effectiveness model”, and the purpose of this study is to explore the structure of the shot effectiveness model for elite table tennis, including the importance degree of shot effectiveness, and the relationship between them.

Methods
258 matches were selected between the top 50 players in the world from 2019 to 2021 as samples. Multiple regression analysis was used to obtain the standard regression coefficients and game simulation, and the total decision coefficient (TDC) was used to evaluate the importance degrees of shot effectiveness (SE) on match results.

Results
(1) There was little difference in the importance degree of each shot effectiveness between men and women players. (2) The importance degree of the first and third shots (SE1), the second and fourth shots (SE2), the fifth and after shots (SE3), and the sixth and after shots (SE4) for both men and women players account for approximately 25%, 35%, 22%, and 16% respectively. (3) There was little difference in the importance degree of each shot effectiveness between Chinese women players and women players from other countries and regions with the same importance order of SE2 > SE1 > SE3 > SE4. However, the structure of the shot effectiveness model for men players was quite different from that for women players. (4) There is a compensation effect between shot effectiveness of table tennis players, and the total evaluation score of 12 and 13 is the dividing line for success or failure in both men and women matches.

Conclusions
TDC could well reflect the important degrees of each shot effectiveness in various ways on winning probability in table tennis matches. And this study compared the importance of several types of players’ performance on the probability of winning a match. In addition, we found that there is a compensation effect between shot effectiveness of table tennis players, and the magnitude of this effect will vary according to the type and level of shot effectiveness.
A new weighted fractional operator with respect to another function via a new modified generalized Mittag–Leffler law
Authors: Thabet Sabri T. M. , Abdeljawad Thabet , Kedim Imed , Ayari M. Iadh 
Published: October 2023

AbstractIn this paper, new generalized weighted fractional derivatives with respect to another function are derived in the sense of Caputo and Riemann–Liouville involving a new modified version of a generalized Mittag–Leffler function with three parameters, as well as their corresponding fractional integrals. In addition, several new and existing operators of nonsingular kernels are obtained as special cases of our operator. Many important properties related to our new operator are introduced, such as a series version involving Riemann–Liouville fractional integrals, weighted Laplace transforms with respect to another function, etc. Finally, an example is given to illustrate the effectiveness of the new results.
CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro
Authors: Liu Ming , Zhang Linlin , Zhong Mingtian , Long Yihao , Yang Wenhui , Liu Ting , Huang Xingxu , Ma Xiaodong 
Published: October 2023

AbstractCAR T cell therapy has been successfully used in the treatment of hematological malignancies, and the strategy that deletion of inhibitory receptor on the CAR T cell surface, such as PD-1, greatly enhance the antitumor effects. Here, we describe a one-step electroporation for the co-transfection of Cas9:sgRNA and CAR plasmids on primary T cells to demonstrate the effect of SHP-1 deletion in CAR T cells. By using PiggyBac Transposase system, we can achieve more than 90% of T cells express CAR gene and nearly 60% SHP-1 knockout efficiency in T cells. We show that knockout of SHP-1 in CD133 CAR T cells resulted in significantly improve the cytolysis effect on CD133 positive glioma cell lines. We further demonstrate that the enhanced antitumor efficacy of SHP-1 deletion is due to the increased release of TNF-α, IL-2 and IFN-γ in vitro. Finally, we evaluated the biosafety of Cas9 genome editing and did not find any insertions of Cas9 and obvious editing in off-target sites in CAR T cells. These data provide an approach for achieving both intracellular inhibitory molecule, SHP-1 deletion and CD133 CAR gene over-expression in human T cells. And SHP-1 could be a new potential target for adoptive CAR T cells immunotherapy.
Short-term effects of a multidisciplinary inpatient intensive rehabilitation treatment on body image in anorexia nervosa
Authors: Brusa Federico , Scarpina Federica , Bastoni Ilaria , Villa Valentina , Castelnuovo Gianluca , Apicella Emanuela , Savino Sandra , Mendolicchio Leonardo 
Published: October 2023

Abstract
Background
Positive changes in weight gain and eating pathology were reported after inpatient treatments for anorexia nervosa (AN). However, changes in the physical body do not always mirror changes in the imagined body. Here, the effect of a treatment focused on body image (BI) was described.

Methods
This retrospective observational study had a quasi-experimental pre-post design without the control group. During the treatment, participants (N = 72) undertake a variety of activities focused on BI. The main outcome was tested through the Body Uneasiness Test.

Results
At the end of the treatment, BI uneasiness decreased with a significant increase in weight gain.

Conclusion
This study highlights the positive short-term effect of a multidisciplinary inpatient intensive rehabilitation treatment on BI in AN. We encourage to design of psychological treatments focusing on the cognitive and emotional bodily representation (i.e. the body in the mind) to increase physical well-being.
Women oppressed in the daily lives and cultural practices of the akha people, Thailand: how can the situation change?
Authors: Wongnuch Pilasinee , Apidechkul Tawatchai , Srichan Peeradone , Mulikaburt Thanatchaporn , Kitchanapaibul Siwarak , Udplong Anusorn , Upala Panupong , Tamornpark Ratipark , Chomchoei Chalitar , Yeemard Fartima , Singkhorn Onnalin 
Published: October 2023

Abstract
Background
Gender equality is one of the most concerning issues globally. Females lacking equality could lead to several impacts, including health and economic impacts. Gender equality is often present in some minorities, such as the Akha hill tribe people who live in remote areas and have poor educational and economic statuses. This study aimed to understand the patterns and forms of women’s oppression through their norms and cultures.

Methods
A qualitative method was used to elicit information from participants in twelve group discussions. The participants were Pha Mee and Ulau Akha people living in six selected villages along the border of Thailand and Myanmar. Twenty-two main questions were used as a guide in the discussions, which were grouped by gender and conducted by a same-gender moderator. The findings were extracted and formed according to a thematic approach.

Results
A total of 72 Akha from six villages were invited to participate in the study: 29 males and 43 females. The average age was 47.7 years, 69.4% were married, 63.8% were Buddhist, 47.2% had never attended a school, and 47.2% worked in the agricultural sector. Several forms of Akha women’s oppression were identified: oppression through daily life, religious rituals, son preference, novels and cradle songs, naming ceremonies, and work performances. Many factors acted as unorthodox patterns to relieve the oppression of Akha women: religious conversion, educational impact, exposure to people from outside villages, and social and economic roles. Oppressed Akha women moved through four layers: individual, family, community, and external culture and modernization. The combination of culture and globalization was a key factor in gender inequity through these four layers to balance the pressures to oppress and resist.

Conclusions
Akha women have lived under the power of men for several years, and these men have built up common features to control women in their society. Improving gender inequity is important for moving to a better stage of health, quality of life, and social roles, which will increase the power of all people to improve their society in the future.
Models of assessment in the classroom: a comparative research of CALL-based vs. traditional assessment on vocabulary learning among Iranian EFL learners
Authors: Shamshiri Fatemeh , Esfahani Fariba Rahimi , Hosseini Seyed Esmail 
Published: October 2023

AbstractThere are a few empirical studies on comparative effects of CALL-based assessment and traditional assessment on Iranian EFL students’ vocabulary learning; therefore, the present research tried to fill this gap. To achieve this purpose, the NELT was administered to 89 EFL students, and 58 of them whose level of English proficiency was the intermediate were chosen for the target sample of the current research. Then, they were randomly divided into two groups of control and experimental, and a vocabulary pre-test was given to them. Next, the experimental group (EG) received a CALL-based assessment treatment, and the control group (CG) received a traditional-based assessment instruction. After instructing 100 new words to both groups, a vocabulary post-test was conducted, and an ANCOVA test and a paired samples t-test were utilized to analyze the scores of the pre- and post-tests. The gained outcomes indicated that the EG outstripped the CG on the post-test of vocabulary. It was concluded that using the CALL-based assessment was more useful than the conventional assessment for learning English vocabulary items. The research findings can be beneficial for EFL teachers, learners, and curriculum designers.
ESSKA consensus initiative: why, when and how?
Authors: Beaufils Philippe , Dejour David , Filardo Giuseppe , Monllau Joan Carles , Menetrey Jacques , Seil Romain , Becker Roland 
Published: October 2023

AbstractThe goal of a Consensus in clinical practice is to provide daily practitioners with evidence‐ based recommendations on data from the literature, clinical expertise and expectations of professionals and patients. In this context, a consensus aligns with the principles of evidence‐based medicine in clinical practice and is consequently regarded as a scientific work of a certain level of evidence (LOE). It is expected that such a project may contribute to filling the gap observed between scientific evidence and reality of the daily practice.A Clinical Consensus is particularly needed for those topics that are of interest to daily practice but controversial due to lack of evidence, and for which expert agreement can provide valuable support in reaching conclusions.A Consensus requires a strict methodology, based on two principles: an iterative process with independence of the involved groups and pluralism (geographical and professional representation). These processes guarantee the scientific quality of the recommendations.Among the various consensus modalities, ESSKA has adopted the Formal Consensus derived from the Delphi method, and the RAND/UCLA appropriateness method. These two methods are complementary. The first one, based on questions‐answers sets, is particularly suitable for questions of terminology, diagnosis, planning, strategy. The second one is based on the concept of scenarios, particularly adapted to treatment indications. These two methods can also be used within the same consensus.The aim of this article is to define what is a consensus initiative, to detail the methodology ESSKA has chosen, and to point out the key role of the dissemination.
Advantage of bulk lightning models for predicting lightning frequency over Japan
Authors: Tomioka Takumi , Sato Yousuke , Hayashi Syugo , Yoshida Satoru , Iwashita Takeshi 
Published: October 2023

AbstractThis study examined the performance of an explicit bulk lightning model coupled with a meteorological model for forecasting lightning by numerical weather prediction over Japan. The evaluation was conducted by comparing the lightning predicted by the explicit bulk lightning model, diagnosed empirically by the numerical model, and observed by ground base measurements. From the results, the bulk lightning model performed better in terms of lightning frequency than did the diagnostic scheme, which overestimated the lightning frequency, although there were no appreciable differences in the score of each method for the geographical distribution and time correlation compared with the observations. These results suggest that the explicit bulk lightning model is advantageous for predicting lightning frequency. The sensitivity of the simulated lightning to the choice of cloud microphysical model was also examined by using a two-moment and a one-moment bulk microphysical scheme. Sensitivity experiments on the choice of microphysical model indicated that the two-moment bulk scheme reproduced the observed lightning well, while the one-moment bulk scheme overestimated the lightning frequency. Analyses suggested that the overestimation of the lightning in the one-moment bulk scheme originated from active charge separation by riming electrification, in which graupel was produced more frequently and was assumed to fall faster. These results suggest that the explicit bulk lightning model with the two-moment bulk microphysical scheme offers an alternative to conventional lightning prediction methods.
Graphical abstract
Deep learning-based algorithm for postoperative glioblastoma MRI segmentation: a promising new tool for tumor burden assessment
Authors: Bianconi Andrea , Rossi Luca Francesco , Bonada Marta , Zeppa Pietro , Nico Elsa , De Marco Raffaele , Lacroce Paola , Cofano Fabio , Bruno Francesco , Morana Giovanni , Melcarne Antonio , Ruda Roberta , Mainardi Luca , Fiaschi Pietro , Garbossa Diego , Morra Lia 
Published: October 2023

Abstract
Objective
Clinical and surgical decisions for glioblastoma patients depend on a tumor imaging-based evaluation. Artificial Intelligence (AI) can be applied to magnetic resonance imaging (MRI) assessment to support clinical practice, surgery planning and prognostic predictions. In a real-world context, the current obstacles for AI are low-quality imaging and postoperative reliability. The aim of this study is to train an automatic algorithm for glioblastoma segmentation on a clinical MRI dataset and to obtain reliable results both pre- and post-operatively.

Methods
The dataset used for this study comprises 237 (71 preoperative and 166 postoperative) MRIs from 71 patients affected by a histologically confirmed Grade IV Glioma. The implemented U-Net architecture was trained by transfer learning to perform the segmentation task on postoperative MRIs. The training was carried out first on BraTS2021 dataset for preoperative segmentation. Performance is evaluated using DICE score (DS) and Hausdorff 95% (H95).

Results
In preoperative scenario, overall DS is 91.09 (± 0.60) and H95 is 8.35 (± 1.12), considering tumor core, enhancing tumor and whole tumor (ET and edema). In postoperative context, overall DS is 72.31 (± 2.88) and H95 is 23.43 (± 7.24), considering resection cavity (RC), gross tumor volume (GTV) and whole tumor (WT). Remarkably, the RC segmentation obtained a mean DS of 63.52 (± 8.90) in postoperative MRIs.

Conclusions
The performances achieved by the algorithm are consistent with previous literature for both pre-operative and post-operative glioblastoma’s MRI evaluation. Through the proposed algorithm, it is possible to reduce the impact of low-quality images and missing sequences.
Exosome-bearing hydrogels and cardiac tissue regeneration
Authors: Amini Hassan , Namjoo Atieh Rezaei , Narmi Maryam Taghavi , Mardi Narges , Narimani Samaneh , Naturi Ozra , Khosrowshahi Nafiseh Didar , Rahbarghazi Reza , Saghebasl Solmaz , Hashemzadeh Shahriar , Nouri Mohammad 
Published: October 2023

Abstract

Background
In recent years, cardiovascular disease in particular myocardial infarction (MI) has become the predominant cause of human disability and mortality in the clinical setting. The restricted capacity of adult cardiomyocytes to proliferate and restore the function of infarcted sites is a challenging issue after the occurrence of MI. The application of stem cells and byproducts such as exosomes (Exos) has paved the way for the alleviation of cardiac tissue injury along with conventional medications in clinics. However, the short lifespan and activation of alloreactive immune cells in response to Exos and stem cells are the main issues in patients with MI. Therefore, there is an urgent demand to develop therapeutic approaches with minimum invasion for the restoration of cardiac function.

Main body
Here, we focused on recent data associated with the application of Exo-loaded hydrogels in ischemic cardiac tissue. Whether and how the advances in tissue engineering modalities have increased the efficiency of whole-based and byproducts (Exos) therapies under ischemic conditions. The integration of nanotechnology and nanobiology for designing novel smart biomaterials with therapeutic outcomes was highlighted.

Conclusion
Hydrogels can provide suitable platforms for the transfer of Exos, small molecules, drugs, and other bioactive factors for direct injection into the damaged myocardium. Future studies should focus on the improvement of physicochemical properties of Exo-bearing hydrogel to translate for the standard treatment options.

Graphical Abstract
Oral galvanism related to dental implants
Authors: Kim Soung Min 
Published: October 2023

Abstract
Background
A range of different chemical interactions can generate an unexpected electronic current in a process called galvanism. Oral galvanism (OG) can also be generated by different chemical actions from diverse intraoral rehabilitated metals, including gold, copper, mercury, titanium, and titanium alloy. The main aim of this manuscript is to review OG, particularly focusing on titanium implants and related metallic materials. We searched the MEDLINE (PubMed), Embase, Scopus, and Google Scholar databases for relevant literature published through December 2019. The keywords included “galvanic current”, “galvanism”, “galvanic corrosion”, “oral galvanism”, combined with “oral”, “oral cavity”, “implant”, and “saliva.”

Results
Out of 343 articles, 126 articles that met the inclusion criteria were reviewed. We examined and summarized research on OG through a division into four categories: definition and symptoms, diagnosis with testing methods, galvanic corrosion, and oral precancerous lesions with OG.

Conclusions
Patients with OG have high oral energy and current, and although this phenomenon may be due to the patient’s mental illness, OG due to amalgam or mercury occurs. It is evident that the difference in electron potential caused by different elemental components such as titanium alloy and pure titanium, which are essential for manufacturing the implant fixture and the abutment, and chrome and nickel, which are essential for manufacturing the upper crown, causes OG. Since the oral cavity is equipped with an environment in which electric current can be transmitted easily due to saliva, it is imperative that clinicians review the systemic and local effects of salivation.