bluuebunny/crossref_metadata_2025_split huggingface dataset:
HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype
Authors: Jacolot Sandrine , Le Gac Gerald , Scotet Virginie , Quere Isabelle , Mura Catherine , Ferec Claude 
Published: December 2003

Abstract
Hereditary hemochromatosis is a genetically heterogeneous disease of iron metabolism. The most common form of the disorder is an adult-onset form that has mainly been associated with the HFE pC282Y/pC282Y genotype. The phenotypic expression of this genotype is very heterogeneous and could be modulated by both environmental factors and modifier genes. The non-HFE hereditary hemochromatosis forms include a juvenile onset form associated with mutations in HAMP. From a cohort of 392 C282Y homozygous patients, we found 5 carriers of an additional HAMP mutation at the heterozygous state (pR59G, pG71D, or pR56X). We found that iron indices of these 5 patients were among the most elevated of the cohort. Moreover, we specified that the HAMP mutations were not detected in 300 control subjects. These results revealed that mutations in HAMP might increase the phenotypic expression of the pC282Y/pC282Y genotype. From a cohort of 31 patients with at least one chromosome lacking an HFE mutation, we further identified 4 males carrying a heterozygous HAMP mutation (pR59G or pG71D). Based on a digenic model of inheritance, these data suggest that the association of heterozygous mutations in the HFE and HAMP genes could lead, at least in some cases, to an adult-onset form of primary iron overload. (Blood. 2004;103:2835-2840)
In situ demonstration of dendritic cell migration from rat intestine to mesenteric lymph nodes: relationships to maturation and role of chemokines
Authors: Kobayashi Hisashi , Miura Soichiro , Nagata Hiroshi , Tsuzuki Yoshikazu , Hokari Ryota , Ogino Takashi , Watanabe Chikako , Azuma Toshifumi , Ishii Hiromasa 
Published: December 2003

AbstractDendritic cells (DCs) are continuously transported from the intestine to mesenteric lymph nodes (MLNs). The objective of this study was to determine the migration kinetics of DCs via intestinal lymph and to investigate regulatory factors affecting their migration in vivo. DCs were obtained from spleen or thoracic duct lymph of mesenteric lymphadenectomized rats. The DCs were fluorescently labeled and injected into the subserosa of the small intestine near the cecum, and their migration patterns into MLNs were determined. Isolated DCs from intestinal lymph express intercellular adhesion molecule-1 (ICAM-1), CD11b/c, CD80/86, and major histocompatibility complex class II but maintain their ability to phagocytize latex particles, suggesting the presence of immature DCs. The isolated DCs accumulated in MLNs in a time-dependent manner with maximal accumulation at 48 h. Cytokine-induced maturation of lymph DCs did not cause a change in cell number but accelerated their transport into MLNs with a maximum at 24 h. Splenic DCs showed an intermediate level of maturation and a migration pattern similar to mature DCs. Inhibition of ICAM-1 or CD11b/c did not affect DC migration. Migration of mature DCs to MLNs was specifically blocked by desensitization of CCR7 with CCL21. In contrast, freshly isolated lymph DCs were not chemotactic for CCL21, but their migration to MLNs was mainly inhibited by desensitization of CCR6 with CCL20. The migratory ability of DCs correlates well with their degree of maturation, and different chemokine/chemokine receptor use may be the main regulator of DC migration kinetics through intestinal lymph.
Phase I Trial Using a Time-to-Event Continual Reassessment Strategy for Dose Escalation of Cisplatin Combined With Gemcitabine and Radiation Therapy in Pancreatic Cancer
Authors: Muler Jeffrey H. , McGinn Cornelius J. , Normolle Daniel , Lawrence Theodore , Brown Diane , Hejna Gwen , Zalupski Mark M. 
Published: December 2003

Purpose The primary objective of this study was to determine the maximum-tolerated dose of cisplatin that could be added to full-dose gemcitabine and radiation therapy (RT) in patients with pancreatic cancer. Patients and Methods Nineteen patients were treated. Gemcitabine 1,000 mg/m2 was administered over 30 minutes on days 1, 8, and 15 of a 28-day cycle. Cisplatin followed gemcitabine on days 1 and 15. The initial dose level of cisplatin was 30 mg/m2, escalated to a targeted dose of 50 mg/m2 using Time-to-Event Continual Reassessment Method. RT was initiated on cycle 1, day 1, in 2.4 Gy fractions to a total dose of 36 Gy. A second cycle of chemotherapy was planned following a 1-week rest. Results Four of eight patients experienced acute dose limiting toxicity at the 50 mg/m2 cisplatin dose level. Patients treated at 30 and 40 mg/m2 cisplatin dose level tolerated therapy without dose-limiting toxicity. Median survival was 10.7 months (95% CI, 5.4 to 18.2) for all patients, and 12.9 months (95% CI, 7.4 to 21.2) for those without metastasis. Conclusion Cisplatin at doses up to 40 mg/m2 may be safely added to full-dose gemcitabine and conformal RT. The Time-to-Event Continual Reassessment Method trial design allowed rapid completion of the study and confidence in the conclusion about the maximum tolerated dose, but accrued more patients to a dose level above the maximum tolerated dose than the typical phase I design. Local and systemic disease control and survival in this study cohort supports further investigation of gemcitabine-based RT and combination chemotherapy in this disease.
Sphingolipid-Cholesterol Domains (Lipid Rafts) in Normal Human and Dog Thyroid Follicular Cells Are Not Involved in Thyrotropin Receptor Signaling
Authors: Costa M. J. , Song Y. , Macours P. , Massart C. , Many M. C. , Costagliola S. , Dumont J. E. , Van Sande J. , Vanvooren V. 
Published: December 2003

Abstract
Partition of signaling molecules in sphingolipid-cholesterol-enriched membrane domains, among which are the caveolae, may contribute to signal transduction efficiency. In normal thyroid, nothing is known about a putative TSH/cAMP cascade compartmentation in caveolae or other sphingolipid-cholesterol-enriched membrane domains. In this study we show for the first time that caveolae are present in the apical membrane of dog and human thyrocytes: caveolin-1 mRNA presence is demonstrated by Northern blotting in primary cultures and that of the caveolin-1 protein by immunohistochemistry performed on human thyroid tissue. The TSH receptor located in the basal membrane can therefore not be located in caveolae. We demonstrate for the first time by biochemical methods the existence of sphingolipid-cholesterol-enriched domains in human and dog thyroid follicular cells that contain caveolin, flotillin-2, and the insulin receptor. We assessed a possible sphingolipid-cholesterol-enriched domains compartmentation of the TSH receptor and the α- subunit of the heterotrimeric Gs and Gq proteins using two approaches: Western blotting on detergent-resistant membranes isolated from thyrocytes in primary cultures and the influence of 10 mm methyl-β-cyclodextrin, a cholesterol chelator, on basal and stimulated cAMP accumulation in intact thyrocytes. The results from both types of experiments strongly suggest that the TSH/cAMP cascade in thyroid cells is not associated with sphingolipid-cholesterol-enriched membrane domains.
A study on the numerical analysis of magnetic flux density by a solenoid for magnetically impelled arc butt welding
Authors: Kim J-W , Choi D-H 
Published: December 2003

The magnetically impelled arc butt (MIAB) welding process uses a rotating arc as its heat source and is known as an efficient method for pipe butt welding. The arc in the gap of the pipe butt joints is rotated along the circumferential weld line by the electromagnetic force resulting from the interaction of the arc current and the magnetic field in the gap. The electromagnetic force is determined by the magnetic flux density in the gap, the arc current and the arc length (i.e. gap size). In particular, the radial magnetic flux density is an important factor in arc rotation and weld quality. This paper proposes a two-dimensional finite element model for the analysis of magnetic flux density distributions in the MIAB welding process. The magnetic flux density is mainly dependent on the gap size between two pipes, the position of the exciting coil that generates the magnetic field, the exciting current in the coil, and the relative permeability of the pipes. Thus, the relations between the magnetic flux density and the above main factors were investigated through experiments and analyses. Experiments were performed on the steel pipes (outer diameter 48.1mm and thickness 2.0mm). From the analyses and experiments, it was revealed that the magnetic flux density in the gap between the pipes increases when there is an increasing exciting current and relative permeability, and a decreasing distance from the gap centre to the coil and gap size. It is considered that the numerical analysis model proposed in this study can be used as a useful means when designing an electromagnetic system for the MIAB welding machine.
5% Imiquimod cream for external anogenital warts in HIV-infected patients under HAART therapy
Authors: Cusini M , Salmaso F , Zerboni R , Carminati G , Vernaci C , Franchi C , Locatelli A , Alessi E 
Published: December 2003

The efficacy of imiquimod in the treatment of external genital warts in HIV positive subjects was compared to a group of patients with normal immune function. Imiquimod 5% cream was applied by patients three times a week until resolution for a maximum of 16 weeks. Assessment for response and the occurrence of side effects was performed every four weeks. Thirty-one per cent of 75 HIV positive patients achieved a complete clearance, a partial response was obtained in 24% of subjects while in 45% we observed no clinical response. In the control group a total clearance was obtained in 62% of subjects, a partial response in 24% and no response in 14%. Recurrences occurred in 4/23 HIV patients and 2/31 immunocompetent patients within three months of follow-up. Side effects were minor to moderate. We conclude that imiquimod 5% cream has an acceptable efficacy and safety on HIV patients.
Mycoplasma genitalium in chronic non-gonococcal urethritis
Authors: Taylor-Robinson D , Gilroy C B , Thomas B J , Hay P E 
Published: December 2003

Seventy-eight men with a history of chronic urethritis were referred for investigation. Of 52 men diagnosed as having persistent or recurrent non-gonococcal urethritis (NGU) at the time of referral, 11 (21%) were infected with Mycoplasma genitalium and three with Chlamydia trachomatis. Men who were M. genitalium-positive had not previously received less antibiotic, in terms of treatment duration, than those who were M. genitalium-negative, suggesting a possible resistance to the antibiotics given. In the current investigation, of 11 M. genitalium-positive men with persistent or recurrent NGU who were treated for four to six weeks with erythromycin, 500mg four times daily, nine (82%) responded clinically and microbiologically, but later six relapsed without M. genitalium being detected. The results of observing and investigating a patient for about one year, the only one to have concurrent chlamydial and mycoplasmal infections, is presented, a feature being the intermittent persistence of the mycoplasma.
Prädiktive Regelung mit Dynamischer Programmierung für nichtlineare Systeme erster Ordnung (Predictive Control with Dynamic Programming for First Order Nonlinear Systems)
Authors: Back Michael , Terwen Stephan 
Published: December 2003

Abstract
Dieser Beitrag beschreibt die Einbindung der Dynamischen Programmierung nach Bellman in die Modellbasierte Prädiktive Regelung für nichtlineare Systeme erster Ordnung. Dabei wurden die Besonderheiten der Kombination dieser beiden Verfahren ausgenutzt, um eine Reduktion des Rechenaufwandes zu erzielen. Diese Reduktion wird anhand der Simulation einer prädiktiven Antriebsregelung eines Hybridfahrzeuges demonstriert.
Stabilitätseigenschaften nichtlinearer Abtastsysteme (Stability Properties of Nonlinear Sampled-data Systems)
Authors: Hohmann Sören 
Published: December 2003

Abstract
Dieser Beitrag gibt einen Überblick über die Stabilitätseigenschaften von nichtlinearen Abtastsystemen. Ausgegangen wird von einer Betrachtung des Abtastprozesses bei nichtlinearen Systemen. Bei der Analyse der Ruhelagen, der Stabilität, des relativen Grads und der Nulldynamik der Abtastsysteme wird herausgearbeitet, in welcher Weise diese Eigenschaften von denen des zugrunde liegenden zeitkontinuierlichen Systems und der Abtastzeit abhängen. Daraus lassen sich prinzipielle Anforderungen an die Erstellung eines Abtastmodells ableiten, wenn dieses bestimmte Eigenschaften aufweisen soll.
Aktive Beeinflussung des Eigenlenk- und Wankverhaltens eines Pkws (Influencing Vehicle Handling and Roll Dynamics)
Authors: Öttgen Oliver , Bertram Torsten 
Published: December 2003

Abstract
Die Sicherheit von Pkws wurde durch den Einsatz von aktiven und passiven Sicherheitssystemen erheblich gesteigert. Durch die Einführung eines aktiven Fahrwerks kann die Sicherheit von Pkws weiter erhöht sowie das Handling und der Komfort verbessert werden, da es die Größe und Verteilung der Normalkräfte an den vier Rädern beeinflusst. Somit ist eine Regelung der Vertikal-, Nick- sowie Wankbewegung und des Eigenlenkverhaltens möglich. Die Einflussnahme auf das Eigenlenkverhalten wird durch die Verteilung der Wanksteifigkeiten an der Vorder-beziehungsweise Hinterachse realisiert, wobei die Regelung auf aktiven Stabilisatoren basiert. Auf diese Weise wird das Querkraftpotenzial ausgeschöpft, die kritische Querbeschleunigung beim Übergang zum übersteuernden Verhalten heraufgesetzt und der Verlust an Lenkwilligkeit gegenüber einer neutralen Abstimmung kompensiert.
Texturanalyse von Bandgut- und Straßenoberflächen (Texture Analysis of Industrial and Road Surfaces)
Authors: Haus J. , Schaefer R. 
Published: December 2003

Abstract
Die Echtzeitanalyse bewegter Oberflächen wird heute bevorzugt mit CCD–Kameras, leistungsfähiger Hardware und ausgeklügelten Algorithmen vorgenommen, erfordert aber den Umgang mit riesigen Datenmengen in kürzester Zeit. In diesem Beitrag soll ein alternatives Verfahren vorgeschlagen werden, das das Kreuzkorrelationssignal zwischen der Oberfläche und einem optischen Gitter zur Inspektion heranzieht.
Ein neues beugungsbasiertes Laser-Messverfahren zur Teilchengrößenmessung (A New Diffraction-based Laser Measuring Principle for Particle Sizing)
Authors: Ruck B. , Pavlovski B. 
Published: December 2003

Abstract
Die vorliegende Arbeit beschreibt ein neues laseroptisches Messprinzip zur Messung des Durchmessers von in Fluiden suspendierten Kleinstteilchen bis hinunter in den Mikrometerbereich. Das neue Verfahren kann auf zwei Arten realisiert werden. Bei der ersten Version (sendeseitige Rotation) wird ein Laserstrahl in einem zuvor definierten Winkelbereich während der Messung um das zu analysierende Teilchen geführt, wobei das sich hinter dem Teilchen ergebende Beugungsmuster im Raum mitgedreht und über einen Punktdetektor geführt wird. Bei der zweiten Variante (empfangsseitige Rotation) erfolgt die Beleuchtung des zu analysierenden Teilchens feststehend und das für den Teilchendurchmesser charakteristische Beugungsmuster wird über einen Drehspiegel hinter dem Teilchen im Raum gedreht und über einen Punktdetektor geführt. In beiden Fällen detektiert ein einfacher Punktdetektor das über ihn hinwegstreichende Beugungsmuster des zu analysierenden Teilchens als zeitveränderliches Signal. Dieses Signal kann anschließend im Zeitbereich oder im Frequenzbereich ausgewertet werden. Aus der Information aus vielen Einzelteilchenmessungen kann die Teilchengrößenverteilung bestimmt werden.
Zur Identifizierung von Lochmustern (Identifying Plane Hole Patterns)
Authors: Späth H. 
Published: December 2003

Abstract
Es werden numerische Verfahren zur Identifizierung von Lochmustern bzw. Punktemengen entwickelt. Ziel ist es, zwei Punktemengen in der Ebene daraufhin zu untersuchen, ob sie durch eine Drehung und eine Translation näherungsweise zur Übereinstimmung gebracht werden können.
Anwendung einer segmentierten geoelektrischen Sonde zur Leckagendetektion in Abwasserkanälen (Applying a Multi-Segmented Geoelectrical Probe for Leak Detection in Sewer Systems)
Authors: Wolf Leif 
Published: December 2003

Abstract
Innerhalb des interdisziplinären Forschungsprojektes SAM (Schadensdetektion an Abwasserkanälen mit Multisensorsystemen) wurden auch geoelektrische Messmethoden bezüglich ihrer Eignung zur Integration in das zu entwickelnde Multisensorsystem untersucht. Das Prinzip ist hierbei das Messen des elektrischen Feldes in der Umgebung der durch den wassergefüllten Kanal gezogenen Sonde. Wassergefüllte Risse und sonstige Öffnungen sind zumeist durch niedrigere elektrische Widerstände als das intakte Rohr gekennzeichnet und erzeugen daher messbare Anomalien in der Feldverteilung. Während zu einzelnen Versuchen auch eine eigene Sondenkonstruktion verwendet wurde, bezieht sich die Mehrzahl der Versuche auf die neu konstruierte Multisegmentsonde AMS-4 S50 R der Firma Seba Dynatronic, Baunach. Die Messungen zeigten gute Korrelationen mit den bekannten Schäden an den Testanlagen. Das Signal der AMS4-Sonde wird deutlich von der Größe des Lecks beeinflusst und ist gut geeignet für die Fusion mit anderen Sensorsystemen
Hohlraumdetektion in der Umgebung erdverlegter Abwasserkanäle mit Hilfe einer γ-γ-Sonde
Authors: Heske Claus 
Published: December 2003

Abstract
Hohlräume in der Umgebung erdverlegter Kanäle können zu Rohrbrüchen, Oberflächenabsenkungen und Fahrbahneinbrüchen führen. Die Hohlräume entstehen dort, wo über Leckagen Bodenmaterial in den Kanal eingespült wird; sie sind mit den bisher angewendeten Verfahren der Kanalinspektion nicht zu orten. Mit Hilfe einer γ-γ-Sonde können Hohlräumen in der Umgebung der Kanäle aufgrund ihrer geringen Dichte im Vergleich zum umgebenden Erdreich detektiert werden.
Crystal structures of the double salt dihydrates K2Cd(SeO4)2·2H2O, K2Mn(SO4)2·2H2O, (NH4)2Cu(SeO4)2·2H2O and KFeH(SO4)2·2H2O
Authors: Fleck Michel , Kolitsch U. , Hertweck B. , Giester G. , Wildner M. , Prem M. , Wohlschläger A. 
Published: December 2003

Abstract
The crystal structures of the four synthetic double salt compounds K2Mn(SO4)2·2H2O (space group P1̅, no. 2, Z = 2, a = 6.574(1), b = 7.332(1), c = 10.700(1) Å, α = 72.89(1), β = 73.91(1), γ = 69.77(1)°, V = 453.6(1) Å3) and K2Cd(SeO4)2·2H2O(space group P1̅, no. 2, Z = 2, a = 6.625(1), b = 7.542(1), c = 11.349(1) Å, α = 72.17(1), β = 74.55(1), γ = 70.13(1)°, V = 499.3(1) Å3) as well as (NH4)2Cu(SeO4)2·2H2O (space group P1̅, no. 2, Z = 1, a = 5.784(1) Å, b = 7.107(1) Å, c = 7.371(1) Å, α = 104.21(2)°, β = 93.04(2)°, γ = 112.27(2)°, V = 268.19(7) Å3), and KFeH(SO4)2·2H2O(space group P1̅, no. 2, Z = 1, a = 4.626(1), b = 5.820(1), c = 8.265(1) Å, α = 103.86(1), β = 99.77(1), γ = 95.66(1)°, V = 210.64(2) Å3) have been determined from single-crystal X-ray diffraction data collected with a CCD area detector at 293 K, and were refined to R(F) = 0.0231, 0.0251, 0.0230 and 0.0194, respectively. The first two compounds are isostructural. The atomic arrangements are described, with a focus on the hydrogen bonding. All compounds contain kröhnkite [Na2Cu(SO4)2·2H2O]-type tetrahedral-octahedral chains but show different topological arrangements of these chains. A classification is proposed in an accompanying paper. A particular feature of KFeH(SO4)2·2H2O is a disordered H atom involved in a short hydrogen bond, which shows no ordering down to 110 K.
The crystal structure of Bi4O5I2 and its relation to the structure of Bi4O5Br2
Authors: Keller E. , Krämer V. , Schmidt M. , Oppermann H. 
Published: December 2003

Abstract
The crystal structure of Bi4O5I2 has been solved from a 3:1 twinned crystal; accurate lattice parameters have been determined by a Rietveld refinement. Bi4O5I2 crystallizes with space group P21 (no. 4), Z=4, a=14.944(1), b=5.6983(3), c=11.263(1) Å, β= 99.81(1)°. Its structure is isotypic to the structure of the homologous Bi4O5Br2 for which more reliable lattice parameters have been determined by a Rietveld refinement. The effects of replacement of Br by I on the structure are discussed and compared with corresponding effects in the BiOX family (X = Cl, Br, I). A structural reason for the deviation of the twin supercells of the two compounds from orthogonality is discussed.
Initial Processes of Laser Induced Diatomic Molecular Photodissociation in Matrices: Quantum Simulations for F2 in Ar in Reduced Dimensionality
Authors: Korolkov M. V. , Manz J. 
Published: December 2003

Abstract
Quantum dynamical simulations of ultrafast processes of F2 in an Ar matrix induced by a pump laser pulse show that photoexcitation (i) is followed by (ii) a stretch of the dissociative bond, (iii) collision with, vibrational excitations of, and possible exit through the nearest neighbour atoms of the surrounding cage, and (iv) finally, subsequent rescattering of the dissociated atoms causing vibrations of additional matrix atoms. If the laser pulse ended before the onset of process (iii), the initial steps (i) and (ii) are similar to photodissociations in the gas phase and are, therefore, well described in terms of the wavepacket dynamics of the diatomic molecule in reduced dimensionality. For specific symmetry constraints, the initial processes (i), (ii), and (iii) may be described in terms of just 1- and 2- or 3-dimensional wavepacket dynamics, respectively. At the end of the laser pulse, this low-dimensional wavepacket may serve to prepare the high-dimensional one for the subsequent laser-free dynamics of the total system.
Fine Theoretical Spectroscopy Using SAC-CI General-R Method: Outer- and Inner-Valence Ionization Spectra of N2O and HN3
Authors: Ehara M. , Yasuda S. , Nakatsuji H. 
Published: December 2003

Abstract
Fine theoretical spectroscopy for the outer- and inner-valence ionization spectra has been presented by using the SAC-CI (symmetry adapted cluster-configuration interaction) general-R method applied to N2O and HN3. The SAC-CI general-R method accurately simulated the experimental spectra and the detailed assignments of the satellite peaks were proposed. The continuous peaks I ∼ V of N2O observed by the dipole (e,2e) spectroscopy were finely reproduced. In particular, the low-lying satellites were calculated in good agreement with the experiment; two 2Π shake-up states at the foot of the C state, 2Σ and 2Π states for the peak I. For HN3, new interpretation was proposed for the outer-valence region, namely, peaks 3 ∼ 5 are composed of the mixture of the single-electron main peaks and the two-electron shake-up peaks. Inner-valence ionization spectrum of HN3 was theoretically predicted for which no experimental spectrum has been reported.