bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocular Manifestations of Antiphospholipid Syndrome in Jordan
Authors: Al-Zubi Khalid , Sarayrah Fawaz 
Published: November 2023

Abstract:

PURPOSE:
The purpose of the study was to evaluate the prevalence of various ocular manifestations in diagnosed cases of antiphospholipid syndrome (APS) in Jordan. It will also find the association of these manifestations with primary and secondary APS.

METHODS:
It was a retrospective cross-sectional study to analyze the ocular manifestations of APS in Jordan. Data of 90 cases were obtained from public hospitals from January 2018 to January 2021. There should have been at least two positive tests with a minimum of 12-week gap between them. The electronic data regarding Schirmer tests, examination of visual acuity (Snellen acuity), neuro-ophthalmic manifestations, dilated fundus examination for posterior eye segment manifestations, and slit-lamp examination for anterior eye segment were also recorded and analyzed. Using SPSS version 25, the frequency and percentages of the categorical data were computed. Pearson’s Chi-square test was conducted to find the associations.

RESULTS:
Among 90 APS cases, 52 (58%) patients had primary APS and 38 (42%) had secondary APS. At the same time, systemic lupus erythematosus was diagnosed in 31 (34%) patients. Keratoconjunctivitis sicca (dry eyes), decreased vision, and retinal vasculitis were the most common manifestations observed.

CONCLUSION:
The high prevalence of ocular manifestations warrants ophthalmologists to look for APS, as ocular manifestations could be the initial symptoms and/or signs of APS.
Prevalence of transfusion transmissible infections among voluntary blood donors: The need for adoption of sensitive screening assays
Authors: Zakari Ayuba , Damulak Dapus Obadiah , Salawu Lateef , Egesie Ochaka Julie , Jatau Ezra Danjuma , James Jasini , Jem Grace Pam 
Published: November 2023

Background:Transfusion-transmissible infections (TTIs) in blood donors increase the risk of acquisition of these infections in blood and blood products recipients. Sensitive screening methods reduce the risk of transmission of TTIs to blood and products recipients.Objectives:The study sought to determine the prevalence of TTIs among voluntary non-remunerated blood donors (VNRBDs) and examine the need for the use of advanced donor screening methods to ensure blood infection safety.Materials and Methods:This was a cross-sectional study conducted at the National Blood Transfusion Service (NBTS). Consenting VNRBD aged 18–65 years, were consecutively recruited during routine blood drives organized by the NBTS, between August and October 2016 after completing a structured questionnaire. Samples from donated blood units were screened for Human immunodeficiency virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), and syphilis using the fourth-generation ELISA.Results:The data obtained from 865 participants were analyzed. One hundred and eighty-two (21%) participants tested positive for TTIs. The prevalence of HBV, HCV, HIV, and syphilis among the participants was 14.7%, 4.6%, 1.8%, and 1.6%, respectively. Coinfection was found in 8.7% of the study participants. A statistically significant association was established between the sex of the participants and TTIs (χ2=6.217,P= 0.0013).Conclusion:The prevalence of TTIs among VNRBD was high. Due to its attendant consequences on blood infection safety and implication on donor retention, there is a need for adoption of sensitive screening assays to ensure blood safety.
Mathematical modeling of water flocculation process with high turbidity: studies and comparative analysis between methods and models
Authors: Graça Josy Krominski , Botari Alexandre 
Published: November 2023

The quality of water used by a population is directly proportional to the efficiency of its treatment. Mathematical modeling appears in this context as a tool for optimizing processes in order to make them more efficient, economical and sustainable. This work analyzed and compared the effectiveness of phenomenological mathematical models used in flocculation kinetics in water treatment. The results were obtained by comparing the Argaman and Kaufman Model with the Bratby Method; the Aggregation and Rupture Equation Method - MEAR; and the Method of the First Partial Derivative in Relation to the Velocity Gradient in Flocculation - MPDPG and a model that includes a new term (KC) that contemplates a supposed process of irreversibility of floc. The mathematical modeling was validated and compared with experimental data. The coefficients of the models and methods were obtained using the Excel® solver® tool using spreadsheets from the same application. It was possible to identify that the Bratby Method, which obtained an average deviation of the order of 30%, was the least efficient, while the MEAR and MPDPG Methods, which obtained about 18% of average deviation and the Kc Model with a deviation of the order of 19%, proved to be efficient in describing the experimental data used.
Keywords: flocculation, mathematical modeling, water treatments.
USO DAS FERRAMENTAS DO PROGRAMA GOOGLE FOR EDUCATION ALIADAS AO ENSINO E APRENDIZAGEM ESCOLAR
Authors: Araujo Camila Sabino de , Nascimento Camilo Eduardo do , Filho Elzo Brito dos Santos , Timoteo Luciene Carneiro da S. O. , Santos Silvana Maria Aparecida Viana 
Published: November 2023

A era digital trouxe inúmeras mudanças em diversas áreas, inclusive na educação, logo para acompanharmos essas mudanças, temos que nos adequar às diversas possibilidades existentes, em um público até então desconhecido, como os ‘Nativos digitais’ e os ‘Letrados Digitais’. Para tanto, a empresa multinacional Google fornece uma gama imensa de aplicativos, que são recursos digitais gratuitos, popularizados no mundo inteiro, para os mais variados setores, até mesmo para a educação. Com esse cenário, refletiremos sobre a importância da ferramenta escolhida e para qual público o processo pode ser utilizado, ademais examinaremos alguns aspectos favoráveis e desfavoráveis e sobre a motivação para a utilização, além dos resultados esperados, com a utilização dessas ferramentas. O objetivo deste trabalho é realizar uma revisão da literatura, para analisarmos as questões citadas, além disso, apresentaremos sucintamente as ferramentas oferecidas pela empresa Google, latentes para utilização em contexto educativo, aliadas ao ensino e aprendizagem escolar com o intuito de proporcionar dinamização das aulas, utilizando recursos mais familiarizados aos alunos desse novo milênio.
IMPACTOS E POSSIBILIDADES DAS TECNOLOGIAS NO CONTEXTO SOCIOEDUCACIONAL
Authors: Miranda Narciso Marques , Kul Erica Tais Souza , Ranzani Rui César , Gallo Solange Aparecida , Lima Vanessa Rodrigues de 
Published: November 2023

Em pleno século XXI, períodos de inúmeras adaptações e transformações, faz-se necessário analisar os impactos do uso da tecnologia na nossa vida diária e, principalmente em nossas relações pessoais. O mundo globalizado que vivemos já está repleto de robôs nos mais variados campos profissionais; são diversas a quantidade de jogos eletrônicos, aplicativos e softwares que dominam, principalmente, adolescentes e jovens. Independentemente de onde ela for utilizada, o fato é que a tecnologia está presente em todos os lugares, ou pelo menos quase todos, na vida de uma pessoa. Quais as implicações que podem ser trazidas através dos usos das tecnologias? Discutir sobre a temática da tecnologia aplicada a educação não é uma tarefa fácil. Se levarmos em consideração que a tecnologia está em todos os setores por onde passamos, nada mais natural que tenha alcançado o setor educacional. A questão se coloca agora, é como educadores, utilizarão essas ferramentas não só para estarem cientes desse novo momento em que estamos, mas também para aperfeiçoar suas aulas. É bem verdade que as tecnologias estão presentes na sala de aula de diversas formas, um PowerPoint, a leitura de um livro digital, a pesquisa de um trabalho, por exemplo, porém ela vem se modificando ao longo dos anos. Esse trabalho tem como objetivo geral destacar a importância de ferramentas tecnológicas na educação. A metodologia seguida para elaboração desse trabalho foi a bibliográfica e de caráter qualitativo. Conclui-se que a tecnologia veio para favorecer aos educadores no ofício de seu trabalho e aos discentes no processo de aprendizagem.
HUBUNGAN TINGKAT PENGETAHUAN IBU DENGAN PEMBERIAN IMUNISASI DASAR PADA BAYI DI PUSKESMAS LAMPASEH BANDA ACEH TAHUN 2023
Authors: Zahra Salsabila Hilmza , Zuheri Zuheri Zuheri , Safirza Satria 
Published: November 2023

Imunisasi pada bayi merupakan langkah penting untuk melindungi kesehatan mereka dari penyakit menular yang berbahaya dan mencegah komplikasi serius. Pengetahuan ibu tentang imunisasi lengkap pada bayi memiliki peran krusial dalam menjaga kesehatan dan keselamatan anak-anak. Imunisasi adalah suatu langkah penting dalam upaya pencegahan penyakit menular berbahaya yang dapat mengancam kehidupan bayi. Melalui vaksinasi yang tepat waktu, bayi dapat membangun sistem kekebalan tubuh yang kuat, sehingga dapat melawan infeksi dan menghindari risiko komplikasi serius yang mungkin terjadi pada usia yang rentan. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan ibu terhadap kelengkapan imunisasi dasar bayi. Penelitian ini menggunakan uji chi square yang digunakan untuk melihat hubungan antar dua vairabel. Sampel pada penelitian berjumlah 126 responden. Hasil yang diperoleh penelitian ini adalah tingkat pengetahuan ibu tentang imunisasi 53,2% mempunyai kategori baik, kelengkapan imunisasi pada bayi 55,6% lengkap, dan hasil uji hubungan menunjukkan bahwa adanya hubungan yang signifikan antara pengetahuan ibu terhadap kelengkapan imunisasi pada bayi. Kata kunci: Imunisasi, Pengetahuan Ibu, Kelengkapan imunisasi
Bioinformatics Analysis Identifies Potential Hub Genes, Therapeutic Agents, and Crucial Pathways in the Pathogenesis of Refsum's Disease
Authors: Sharma Ravinder , Bhullar Anant , Bansal Parveen , Kaur Gunpreet , Gupta Vikas 
Published: November 2023

Refsum Disease is a infrequent, inherited, autosomal recessive condition. The purpose of this study was to investigate prospective therapeutic drugs to cure Refsum disease and to determine the critical genes/pathways through bioinformatics analysis. Using the text mining method, Refsum disease-related genes were discovered and MCODE plugin, GO & KEGG analyses was used to examine modules. A PPI network was created by STRING and visualized in Cytoscape. Drug-gene interactions were investigated using the drug-gene interaction database. Using the text mining of gene (TMG) method, 64 distinct genes in Homo sapiens linked to Refsum illness. There were 71 edges and 48 nodes in a PPI network. 13 hub node genes were discovered using a cluster analysis of filtering nodes. The genes were then significantly elevated in protein trans-membrane transport, protein import to the peroxisome matrix and fatty acid beta-oxidation, according to the enrichment analysis. We discovered that two already-approved medications could target two of the 13 chosen genes. The findings revealed the hub genes for Refsum illness to be SLC27A2, AGXT, GNPAT, CRAT, HSD17B4, AMACR, CAT, SCP2, PEX13, PEX10, PEX1, PEX7, and PEX2. Additionally, Ibuprofen and alcohol were named as prospective therapeutic agents for the management and therapy of Refsum’s illness. Only bioinformatics tools were used in this study further in-vitro and in-vivo studies are required because phenotypic differences will vary from person to person depending on the expressivity of the gene.

Received: 9 August 2023 | Revised: 16 October 2023 | Accepted: 20 November 2023

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The data that support this work are available upon reasonable request to the corresponding author.
Influence of patient trust in provider and health literacy on receipt of guideline-concordant chronic opioid therapy in HIV care settings
Authors: Williams Emily C. , Frost Madeline C. , Lodi Sara , Lira Marlene C. , Tsui Judith I. , Lunze Karsten , Kim Theresa , Liebschutz Jane M. , Del Rio Carlos , Samet Jeffrey H. 
Published: November 2023

Objective: Persons with HIV (PWH) frequently receive opioids for pain. Health literacy and trust in provider may impact patient–provider communication, and thus receipt of guideline-concordant opioid monitoring. We analyzed baseline data of HIV-positive patients on chronic opioid therapy (COT) in a trial to improve guideline-concordant COT in HIV clinics.
Design: Retrospective cohort study.
Setting: Two hospital-based safety-net HIV clinics in Boston and Atlanta.
Patients and participants: A cohort of patients who were ≥18 years, HIV-positive, had received ≥ 3 opioid prescriptions from a study site ≥21 days apart within a 6-month period during the prior year and had ≥1 visit at the HIV clinic in the prior 18 months.
Main outcome measures: Adjusted logistic regression models examined whether health literacy and trust in provider (scale scored 11-55, higher indicates more trust) were associated with: (1) ≥ 2 urine drug tests (UDTs) and (2) presence of an opioid treatment agreement.
Results: Among 166 PWH, mean trust in provider was 47.4 (SD 6.6); 117 (70 percent) had adequate health literacy. Fifty patients (30 percent) had ≥ 2 UDTs and 20 (12 percent) had a treatment agreement. The adjusted odds ratio (aOR) for a one-point increase in trust in provider was 0.97 for having ≥ 2 UDTs (95 percent CI 0.92-1.02) and 1.03 for opioid treatment agreement (95 percent CI 0.95-1.12). The aOR for adequate health literacy was 0.89 for having ≥ 2 UDTs (95 percent CI 0.42-1.88) and 1.66 for an opioid treatment agreement (95 percent CI 0.52-5.31).
Conclusions: Health literacy and trust in provider were not associated with chronic opioid therapy quality outcomes.
Nonprescription use of buprenorphine tablets among patients at a tertiary care addictive disorder treatment center in India: Observations and implications
Authors: Balhara Yatan Pal Singh , Saha Priyanka , Mathew Merlin , Kumar Mukul , Parmar Arpit , Lal Rakesh , Sarkar Siddharth 
Published: November 2023

Objective: Nonprescribed use of drugs is a clinical and public health challenge fueled by diversion of controlled opioids like buprenorphine. In this study, we report the nonprescription use of buprenorphine and buprenorphine–naloxone for the first time in India.
Design: A cross-sectional observational study utilizing semistructured interviews.
Setting: A tertiary care addictive disorder treatment center in India, which provides inpatient and outpatient medically oriented care that includes agonist treatment (buprenorphine) or detoxification and antagonist treatment (naltrexone).
Participants: Patients aged 18-65 years, registered at the center, and who had a history of current (within the past 6 months) nonprescription use of buprenorphine tablets were recruited.
Main outcome measures: Participants were questioned about demographic and clinical factors and details of nonprescription use of buprenorphine and buprenorphine–naloxone using a structured questionnaire. Since both buprenorphine with naloxone and buprenorphine without naloxone are available and transacted on the street “loose” out of the blister packs, we were unable to differentiate the use of plain buprenorphine and a combination of buprenorphine–naloxone.
Results: A majority of the participants used nonprescribed tablets buprenorphine and buprenorphine–naloxone with an intent to control the withdrawal symptoms, and the reason for this use was that other patients shared their prescriptions of these medications. About half of the participants injected the tablets, and liquid pheniramine was most commonly used as the solvent for dissolving the tablets. A “high” was perceived by around half of those who injected. Participants reported knowing, on an average, around 13 peers who injected the tablet buprenorphine or buprenorphine–naloxone.
Conclusion: Nonprescription use of tablets buprenorphine and buprenorphine– naloxone is a clinical concern and also an important public health issue. Geographical and systemic expansions of the availability of buprenorphine may reduce the “demand” for nonprescribed buprenorphine, while the opportunities for diversion from treatment centers can be minimized through more careful clinical prescriptions and monitoring practices.
Phenolic Content and Antioxidant Activity of Leaves and Rhizomes of Etlingera coccinea (Blume) S.Sakai and Nagam. (Zingiberaceae)
Authors: P. Mendez Noe 
Published: November 2023

Most of the Zingiberaceae species in the Philippines have been used as ethnomedicinal plants due to the benefits they possess. One of these species is Etlingera coccinea (Blume) S.Sakai and Nagam. (Zingiberaceae), a species with a variety of uses in Malaysia, Borneo, and Philippines. In this study, ethanolic extracts of the dry weight leaves and rhizomes of E. coccinea were used to determine its phenolic content and antioxidant activity. The total phenolic content and total antioxidant activity were determined using Folin-Ciocalteu and phosphomolybdenum methods, respectively. Data revealed that the total phenolic content of dry weight, expressed as milligram gallic acid equivalent per gram sample (mg GAE/g sample) recorded that the leaves (11.69 ± 0.47 mg GAE/g sample) have greater amount of phenolics than the rhizomes (0.58 ± 0.06 mg GAE/g sample). The total antioxidant activity (TAA), expressed as milligram ascorbic acid equivalent per gram sample (mg AAE/g sample), obtained higher activity in the leaves (12.76 ± 0.31 mg AAE/g sample) than the rhizomes (0.85 ± 0.12 mg AAE/g sample), and the reducing power, expressed as milligram gallic acid reducing power equivalent per gram sample (mg GRPE/g sample) also revealed higher activity for the leaves (9.37 ± 1.88 mg GRPE/g sample) compared to rhizomes (0.28 ± 0.07 mg GRPE/g sample). Based on the correlation analysis, a perfect positive linear relationship was observed among the TPC, TAA, and RP (r=1, p<0.001), which means that phenolic compounds significantly contribute to the antioxidant activities of the extracts of E. coccinea. These data imply that E. coccinea could be potentially used as a new source of natural antioxidant. Furthermore, this paper adds information on the habitat and ecology, phenology, and coloured photographs of this species for future related studies and conservation initiatives.
A Review of Etlingera coccinea (Blume) S. Sakai and Nagam (Zingiberaceae) on Achievement of Producing An Essential Oil and Medicinal Properties in Sabah, East Malaysia.
Authors: Joseph Emmeldah , Godoong Elia 
Published: November 2023

The wild ginger, Tuhau, E. coccinea is a plant species from Etlingera genus and Zingiberaceae family. This study is focused on a reviewed paper reported on the extraction method used to derive essential oils and the overview of the published data regarding medicinal properties of Etlingera coccinea spp. The search was performed in several databases such as ScienceDirect, Scopus, SpringerLink, and Researchgate and also Google Scholar. The following keywords were used individually and or in combination “E. coccinea” and “Tuhau”. This article highlights the extraction techniques used to derive the essential oil of E. coccinea and also provide briefly overview of the medicinal properties from the data in recent literature.
Pengaruh Penambahan Ekstrak Lidah Buaya (Aloe Vera L.) Terhadap Sifat Fisik Gelling Agent Carbopol 940
Authors: Budi Setiawan  , Rosi Rahayu  
Published: November 2023

Lidah buaya memiliki beberapa kandungan senyawa antara lain antrakuinon, lignin, saponin dan tannin. Kandungan tersebut memiliki berbagai macam khasiat. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan ekstak lidah buaya kedalam basis gel carbopol 940. Dengan formula 3%, 5% , 7% ekstrak lidah buaya dan konsentrasi carbopol 2%. Evaluasi yang dilakukan : uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, uji aseptabilitas. Yang dilakukan selama 16 hari di uji setiap 4 hari sekali. Hasil penelitian menunjukkan ekstrak lidah buaya memiliki pengaruh terhadap sifat fisik sediaan gel carbopol 940 diantaranya, perubahan warna yang semakin gelap akibat peningkatan konsentrasi, bentuk sediaan yang semi padat agak cair akibat peningkatan konsentrasi ekstrak lidah buaya, peningkatan pH selama penyimpanan, daya sebar gel yang semakin meluas akibat penambahan ekstrak lidah buaya, penurunan daya lekat gel akibat penambahan konsentrasi ekstrak lidah buaya, dan aseptabilitas yang paling banyak memiliki respon oleh responden adalah formula 3.
REPRESENTASI PERBEDAAN KELAS DALAM CERPEN CINTA PERTAMA (CHŪLIÀN) KARYA MO YAN
Authors: Sontiva Egiva , Wuryandari Nurni Wahyu 
Published: November 2023

First Love short story by Mo Yan tells of the first love story of a 9-year-old male student named Jin Tou to a woman who is older than him. The three previous studies that have discussed this short story all emphasize strong intrinsic elements of the story, namely characters and characterizations. They state that the important characters of the story are Jin Tou, Zhang Ruolan and Du Fenyu, Jin Tou's first love is a mixture of innocence, bitterness and happiness played by the boy who has a strange, lonely and unfortunate character. After being traced, and studied using an intrinsic approach and referring to sources outside the short story, it is revealed that the problem discussed in the short story is about class issues represented by each character in the story. The depiction of social class presented is a representation of the problems that have occurred in China. The short story First Love takes place in the history and social conditions of China in the period after the end of the Cultural Revolution and the reopening of schools in China. This short story also presents how Mo Yan as the author sees the conditions after the Cultural Revolution in China as part of the history conveyed through the love story of Jin Tou's character. AbstrakCerpen Cinta Pertama karya Mo Yan menceritakan tentang kisah cinta pertama seorang siswa laki-laki berusia 9 tahun bernama Jin Tou kepada perempuan yang lebih tua darinya. Tiga penelitian terdahulu yang telah membahas cerpen ini semuanya menekankan unsur intrinsik cerita yang kuat, yaitu tokoh dan penokohan. Mereka menyatakan bahwa tokoh penting dari cerita adalah Jin Tou, Zhang Ruolan dan Du Fengyu, cinta pertama yang diraskan oleh Jin Tou adalah campuran dari kepolosan, kepahitan dan kebahagiaan yang diperankan oleh anak laki-laki yang memiliki karakter aneh, kesepian dan malang. Setelah ditelusuri, dan dikaji dengan pendekatan intrinsik dan mengacu pada sumber diluar cerpen, terungkap bahwa masalah yang dibahas di dalam cerpen adalah tentang persoalan kelas yang direpresentasikan oleh masing-masing tokoh dalam cerita. Penggambaran mengenai kelas sosial yang dihadrikan merupakan representasi dari permasalahan yang pernah terjadi di Cina. Cerpen Cinta Pertama mengambil latar sejarah dan kondisi sosial Cina pada periode setelah Revolusi Kebudayaan berakhir dan dibukanya kembali sekolah di Cina. Cerpen ini juga menyajikan bagaimana Mo Yan sebagai penulis melihat kondisi setelah masa Revolusi Kebudayaan di Cina sebagai bagian dari sejarah yang disampaikan melalui cerita cinta tokoh Jin Tou.