bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Gut Microbiota Profile in Heart Failure Patients: A Systematic Review
Authors: Simadibrata Daniel Martin , Auliani Salwa , Widyastuti Putu Ayu , Wijaya Alya Darin , Amin Hilman Zulkifli , Muliawan Hary Sakti , Siswanto Bambang Budi , Simadibrata Marcellus 
Published: September 2023

Background and Aims: Traditional cardiovascular risk factors are established predictors of heart failure (HF). However, the human gut microbiota is suggested to potentially interact with the cardiovascular system through the “gut-heart axis”, which induces inflammation and contributes to HF pathogenesis. This systematic review aims to confirm the interconnection between the gut microbiome in HF patients.
Methods: Peer-reviewed human studies comparing the gut microbiota profile in adult patients with HF and healthy controls (HCs) up to April 18, 2022, were searched in Ovid MEDLINE, Ovid EMBASE, SCOPUS, and the Cochrane Library. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS).
Results: A total of nine studies, including 317 HF patients and 510 HCs, were included in the review. Decreased gut microbiota richness and similar microbial diversity (alpha diversity), and significantly different gut microbiota composition (beta diversity) were observed between HF patients and HCs. In comparison to HCs, HF patients had a greater abundance of Actinobacteria, Proteobacteria, and Synergistetes phyla; Enterococcus, Escherichia, Klebsiella, Lactobacillus, Streptococcus, and Veilonella genera and Ruminococcus gnavus, Streptococcus sp., and Veilonella sp. species. In contrast, there was decreased abundance of Firmicutes phylum; Blautia, Eubacterium, Faecalibacterium, and Lachnospiraceae FCS020 genera; and Dorea longicatena, Eubacterium rectale, Faecalibacterium prausnitzii, Oscillibacter sp., and Sutterella wadsworthensis species in HF patients.
Conclusions: Gut microbiota diversity, richness, and composition in HF patients differ significantly from the healthy population. Overall, short-chain fatty acid (SCFA)-producing gut microbiota was depleted in HF patients. However, different underlying comorbidities, environments, lifestyles, and dietary choices could affect gut microbiota heterogeneity.
Child Labour – What Can We Do about It?
Authors: Frączek Maciej , Żyła Aleksandra 
Published: September 2023

Background: Despite increasing knowledge of its harmful consequences, child labour is a persistent issue in developing countries; moreover, the number of working children has increased in recent years.
Research objectives: To explore the issue of child labour by defining its drivers and indicating strategies for reducing its extent and impacts. To answer the following research question: What are the feasible solutions to the problem of child labour that might also be applied in the context of social economy or social entrepreneurship?
Research design and methods: The authors rely on a combination of an analytical and synthetic approach and draw mostly on a review of the literature as well as normative acts (in the latter case, taking advantage of the dogmatic-legal method). Information resources comprise scientific research, studies of international institutions, legal acts, and websites. The last section employs heuristic methods to identify new sectors of social economy activity in the context of efforts to combat and prevent child labour. As a result, the considerations are primarily qualitative in nature.
Results: Despite the absence of instances of direct implementation of social economy (entrepreneurship) solutions designed to address the problem of child labour in developing countries, it is possible to identify numerous prospective domains and instruments where this sort of activity might be conducted.
Conclusions: Child labour is a complex issue in developing countries since both internal and external factors contribute to its emergence and perpetuation. Its abolition requires immediate cooperation of multiple institutions and organisations from the governmental, private, and social spheres. It appears that social economy organisations should be included in the list of existing actors in this field.
Rethinking the Effectiveness of Consumer Protection Policies and Measures in the Financial Marketplace
Authors: Iheme Williams C. 
Published: September 2023

This paper aims to identify and challenge the common practice among financial institutions of designing and selling complex financial products to consumers who lack full comprehension, thus preventing them from making informed decisions before consuming such financial products. This deceptive approach leads many consumers to experience financial losses, with significant negative consequences for society as a whole. The paper delves into the motivations behind financial institutions to produce and successfully sell complex financial products; they flourish, mainly because they often take advantage of the inadequate regulatory systems, amongst other things. Furthermore, it explores the enabling environment created by laissez-faire contract, which prioritizes principles like pacta sunt servanda and caveat emptor, resulting in regulators overlooking and undervaluing the abuse faced by financial consumers, leaving them largely responsible for resolving their own challenges. The paper exposes the shortcoming of policy measures aimed at preventing consumer exploitation, including the flawed disclosure rules that place the burden of comprehension on consumers while being manipulated to undermine their full understanding.
Additionally, it critiques the use of complicated language and heavy use of financial jargon in financial information booklets, which, although meeting legal disclosure requirements, hinder the comprehension of consumers. To address these issues, the paper proposes a new disclosure rule grounded in the concepts of caveat venditor and contra proferentem. This rule would require financial institutions to present information against their own self-interest and provide an equal number of disadvantages alongside advantages for the products they offer. Furthermore, it suggests that regulators and courts should play a pivotal role in supervising and assessing compliance, issuing annual performance-rated certificates that financial institutions must prominently display in their establishments and incorporate into their product information leaflets. This approach would allow consumers to easily identify consumer-friendly financial institutions
El matrimonio civil tras la libertad de cultos del sexenio democrático: de una situación de hecho a una realidad de derecho
Authors: Soria Moya Mónica 
Published: September 2023

Bajo el gobierno provisional del sexenio democrático, el anhelo legislativo de influencia liberal promulgó, entre otras, la ley provisional de matrimonio civil obligatorio de 18 de junio de 1870 precedida de una importante reforma constitucional en materia religiosa.
Procalmada la libertad de cultos el matrimonio civil se impuso de hecho desde las juntas revolucionarias. Tras la novedosa pero efímera ley se dotó de efectos civiles a las uniones oficiadas en los ayuntamientos, y pese a su breve vigencia, será referencia para los promotores del Código Civil.
Para ello, en el presente trabajo se analiza la relación Iglesia‑Estado tras la revolución de septiembre, a través del estudio de la prensa y los debates parlamentarios del artículo 21 de la Constitución de 1869 con el que se llega a la secularización del matrimonio con la aprobación de la ley de 18 de junio de 1870.
El oportunismo político evidenció el ensayo que la ley suponía: el matrimonio civil obligatorio se convirtió en ley y el canónico en la costumbre ante la inobservancia de un pueblo de tradición católica.
La monarquía constitucional: la fórmula política de la España liberal
Authors: Pérez Núñez Javier 
Published: September 2023

Recensión de: Juan Ignacio Marcuello Benedicto y Carlos Dardé Morales, La Corona y la Monarquía constitucional en la España Liberal, 1834-1931, Silex, Madrid, 2022, 818 p. ISBN: 978-84-19077-30-1
Enviado el (Submission Date): 02/03/2023Aceptado el (Acceptance Date): 12/04/2023
Dumocala o el Estado imperfecto
Authors: Sánchez Quiñones Luis 
Published: September 2023

La Constitución polaca de 1791 es la gran desconocida de Europa. A pesar de promulgarse unos meses antes de la Constitución francesa del mismo año, su eco nunca alcanzó la resonancia de aquélla. Otorgada en un momento muy delicado para la Reczspospolita, sus orígenes están fuertemente ligados a la crisis del estado polaco, siendo tal trance, la principal razón de su corta existencia. El presente artículo examinará tales hechos y las dificultades que presentó constitucional, así como los motivos de su fracaso.
Fecha de envío / Submission date: 24/03/2023Fecha de aceptación / Acceptance date: 27/04/2023
Dictionary Learning for Single-Channel Passive Seismic Denoising
Authors: Chen Yangkang , Savvaidis Alexandros , Fomel Sergey 
Published: September 2023

Abstract
Passive seismic denoising is mostly performed using a simple band-pass filter, which can be problematic when signal and noise share the same frequency band. More advanced passive seismic denoising methods take advantage of fixed-basis transforms, for example, the wavelet, to remove noise. Here, we present an open-source package for data-driven denoising based on adaptively learning sparse transform. Contrary to the fixed-basis transforms, the proposed method belongs to the adaptive-basis transforms. We learn the 1D features embedded in the passive seismic data from all the available waveform data sets without requiring spatial coherency in a data-driven way. Thus, the new method is flexible to apply in any passive seismic monitoring project because of its data-driven and single-channel nature when implemented. Considering the computationally expensive K-singular-value-decomposition (KSVD) in the traditional dictionary learning framework, we suggest applying a fast SVD-free dictionary learning method that can be readily applicable to process massive seismic data during passive seismic monitoring. The proposed method is applied to two synthetic data examples and three real passive seismic data sets to demonstrate its effectiveness in improving the signal-to-noise ratio, and its potential in applications like arrival picking. The open-source reproducible package can be found in the Data and Resources section.
Çıplak İstatistik’e Bakış
Authors: SEZER Zeynep Afra 
Published: September 2023

Çıplak İstatistik (Kitap incelemesi)
Dartmouth College'daki Rockefeller Center'da öğretim görevlisi ve politika uzmanı Charles Wheelan’ın kaleme aldığı ve 2012 yılında yayınladığı ‘Çıplak İstatistik’ kitabı Buzdağı Yayınevi tarafından Ali Atav çevirisiyle 2018’de Türkiye’de yayınlandı. Çıplak İstatistik; ortalama, medyan, standart sapma, olasılık, korelasyon, merkezi limit teoremi ve regresyon analizi gibi konularda pek çok istatistiksel aracın gerçekte ne olduğunu ve hayatımızda neye karşılık geldiğini formüllere boğulmadan anlaşılır bir dille anlatıyor. Bu değerlendirme yazısında; yazarın kitapta ele aldığı konu başlıklarını bir istatistik öğrencisinin anlatımıyla tek tek ele alıp değerlendirmesi yapılacaktır.
Feto maternal outcomes of fibroid in pregnancy: a retrospective observational study
Authors: Handa Nishtha , Anjali  
Published: September 2023

Background: Uterine fibroid is one of the most common intrauterine masses among females at the reproductive age. Although most of the uterine fibroids are asymptomatic during pregnancy, serious complications may occur. Aim of this study was to assess the obstetric outcome (maternal and fetal) in pregnancy with fibroid.
Methods: A retrospective observational study was performed at Obstetrics and Gynecology Department in ABVIMS and RML hospital. 50 pregnant patients with >2 cm size fibroids were taken in the study. Maternal age, parity, size of the fibroid, complications during pregnancy, and mode of delivery were noted.
Results: The 20% of pregnancies ended up in spontaneous abortions. 60% of them had to undergo caesarean section out of which, 10% was for non-progress of labor (NPOL), 5% for outlet obstruction, 5% with malpresentation, 16% patients with APH, 4% patients had elective LSCS for placenta previa and 10% with previous cesarean who were not willing for vaginal delivery. Other complications; placenta previa 16% and low lying placenta 10% patients, pre-eclampsia 20%, malpresentation 20%. Post-partum hemorrhage (PPH) was seen in 24% of the cases. 4% cases had red degeneration which were managed conservatively. Neonatal outcomes included 30% of babies born preterm, 40% being small for gestational age, 10% having low 1-minute APGAR score and 4% with low APGAR at 5 and 10 min. 30% had NICU admission for varied reasons.
Conclusions: Fibroids in pregnancy may be associated with complications affecting the course of pregnancy and labor. So, pregnancy must be cautiously monitored in the antenatal period, through regular follow-up.
Malaria: a masquerader of cytopenias in leukemia
Authors: Mohan Madhulika , Nagarajan Priyathersini , Karunanidhi Prathibha , Sudagar Sivaranjini , Sneha Latha M. 
Published: September 2023

In developing countries where the prevalence of malaria and cancer are high it can be expected to occur together. 6-year-old male child, a known case of B cell acute lymphoblastic leukemia, on maintenance phase of chemotherapy presented to us with fever. His initial investigations showed no identifiable focus or significant abnormalities. He continued to have high grade fever spikes in spite of stepping up antibiotics. A week after admission he was found to have cytopenias and mild splenomegaly. Peripheral smear and bone marrow aspiration study showed enlarged RBCs infested by Plasmodium vivax. We report this case to make the clinicians aware that malaria can be cause of fever in patients on cancer treatment.
Proteinürisi olan 3 farklı hasta grubunda hastaların anjiotensin dönüştürücü enzim inhibitörü ve/veya anjiotensin reseptör blokörü tedavilerinin karşılaştırılması
Authors: MELEKOĞLU ELLİK Zeynep , SAYİN Burak 
Published: September 2023

Amaç: Proteinürisi olan üç farklı hasta grubunda anjiyotensin dönüştürücü enzim (ACE) inhibitörleri ve anjiyotensin reseptör blokörlerinin etkinlik ve güvenliliğini değerlendirmek
Gereç ve Yöntemler: 24 saatlik idrarda 1 gramdan fazla proteinürisi olan diyabetik nefropati, glomerülonefrit ve böbrek transplantasyonu tanısı olan 168 hasta çalışmaya alındı. Hastalar 1. grup ACE inhibitörü kullananlar, 2. grup anjiyotensin reseptör blokörü (ARB) kullananlar ve 3. grup hem ACE inhibitörü hem de ARB kullananlar olarak üç gruba ayrıldı. Hastaların eşlik eden hastalıkları, kullandığı ilaçlar ve kan üre nitrojeni, kreatinin, potasyum, 24 saatlik idrar protein atılımı, kreatinin klirensini içeren laboratuvar değerleri 0-1-3-6-9-12-18-24.aylarda kaydedildi. Hastaların çalışma başlangıcı ve takibi sonunda ekokardiyografik değişiklikleri kaydedildi.
Bulgular: Her üç grupta da 0. aydaki proteinüri değerleri ile diğer tüm aylardaki proteinüri değerleri arasında istatistiksel olarak anlamlı bir düşüş gözlendi. Hem ACE inhibitörü hem de ARB'leri kullanan grup 3 hastalarda 9. aydan itibaren kreatinin seviyeleri anlamlı derecede yükseldi. Grup 1'deki ACE inhibitörü kullanan hastalarda takibin 9. ayından sonra kreatinin klirensi değerlerinde anlamlı bir azalma saptanırken, grup 3'teki ACE inhibitörü ve ARB kullanan hastaların 12. aydan sonra kreatinin klirensleri değerlerinde istatiksel olarak anlamlı bir düşüş saptandı. Grup 2'de ARB kullanan hastalarda kreatinin klirensinde anlamlı bir azalma görülmedi.
Sonuç:24 saatlik idrarda 1 g'dan yüksek proteinürisi olan hastalar ACEi veya ARB tedavileri almalı ve ACE inhibitörü ve anjiotensin reseptör blokörlerinin kombine tedavisi ise sadece yakından izlenebilecek seçilmiş hastalarda kullanılmalıdır.
Tescalcin knockdown inhibits osteogenic differentiation of rat bone mesenchymal stem cells by Wnt/β-catenin signaling pathway
Authors: Wu Dong , Piao Longhuan , Wang Guangbin 
Published: September 2023

Background: Bone marrow-derived mesenchymal stem cells (BMSCs) have the functions of self-renew and differentiating into osteoblasts, adipocytes and chondrocytes, which are regarded as one of the greatest bioscientific achievements in the regenerative medicine field. Tescalcin (TESC), an EF-hand Ca2+ binding protein, plays a vital role in cell proliferation and differentiation. However, what the role of TESC in BMSCs still is unknown. The purpose of this study was to explore the functions.
Methods: Adenovirus was constructed to decrease the expression of TESC. BML-284 was used to active Wnt/β-catenin signaling pathway. qRT-PCR and western blot was used to detect the expression of mRNA and protein levels. ALP staining and activity were used to detect the change of ALP. ARS staining and quantitative analysis were used to determine the mineralization capacity. Immunofluorescence was used to show the expression of protein.
Results: Firstly, we found that the mRNA and protein levels of TESC was increased during the osteogenic differentiation. Next, we determined that TESC knockdown inhibited the expression of osteogenic-related genes and decreased the capacity of mineralization. Then, we found that Wnt/β-catenin signaling was inhibited after TESC Knockdown by detecting the Wnt/β-catenin signaling pathway-related protein expression. Afterwards, BML-284 was demonstrated to active Wnt/β-catenin signaling successfully and utilized to rescue the negative osteogenic differentiation of TESC knockdown.
Conclusion: In summary, our study indicated that TESC knockdown inhibited osteogenic differentiation of BMSCs by Wnt/β-catenin signaling pathway. We supposed that TESC acted in the progress of osteogenic differentiation as a key regulator. We provided a new target for the application of BMSCs in regenerative medicine.
A New Adaptive Implicit Method for Multicomponent Surfactant-Polymer Flooding Reservoir Simulation
Authors: Batista Fernandes Bruno Ramon , Sepehrnoori Kamy , Marcondes Francisco , Delshad Mojdeh 
Published: September 2023

Summary
In the oil industry, chemicals can improve oil production by mobilizing trapped and bypassed oil. Such processes are known as chemical-enhanced oil recovery (CEOR). Surfactants and polymers are important chemicals used in CEOR with different mechanisms to improve oil recoveries, such as reduction in residual saturation, oil solubilization, and mobility control. However, both surfactant and polymer may increase the cost of oil production, making optimizing these processes essential. Reservoir simulators are tools commonly used when performing such field optimization. The simulation of surfactant flooding processes has been historically performed with the implicit pressure explicit composition (IMPEC) approach. The injection of surfactants requires modeling the brine/oil/microemulsion phase behavior along with other processes, such as capillary desaturation and retention. The microemulsion phase behavior and the complex relative permeability behavior can lead to convergence issues when using fully implicit (FI) schemes. Only recently, the FI approach has been efficiently applied to simulate this process using new modeling. The adaptive implicit method (AIM) can combine the benefits of the FI and IMPEC approaches by dynamically selecting the implicitness level of gridblocks in the domain. This work presents a new AIM in conjunction with recently developed models to mitigate discontinuities in the microemulsion relative permeabilities and phase behavior. The approach presented here considers the stability analysis method as a switching criterion between IMPEC and FI. To the best of our knowledge, the approach presented here is the first AIM to consider the brine/oil/microemulsion three-phase flow in its conception. The new approach uses the finite volume method in conjunction with Cartesian grids as spatial discretization and is applied here for field-scale problems. The new approach is tested for polymer flooding and surfactant-polymer (SP) flooding for problems with several active cells ranging from about a hundred thousand to almost a million. The AIM approach was compared with the FI and IMPEC approaches and displayed little variation in the computational performance despite changes in the timestep size. The AIM also obtained the fastest performance for all cases, especially for SP flooding cases. Furthermore, the results here suggest that the gap in performance between the AIM and FI seems to increase as the number of gridblocks increases.
Development and Evaluation of a Predictive Diagnostic System for Dengue Fever using Machine Learning Techniques
Authors: Khan Jibran Rasheed , Raza Syed Kawish 
Published: September 2023

Abstract
As the world continues to evolve scientifically and climatically, the medical and healthcare sectors face new challenges in the form of newly identified diseases, insects, chemicals, and environmental effects. These new challenges are often more complex and dangerous than existing conditions, and require prompt diagnosis and appropriate treatment to prevent loss of life. This paper presents a study on the development of a presumptive diagnosis system (PDS) for early dengue fever detection. The proposed system aims to assist medical professionals in determining the disease at an early stage and help unprofessional or new staff to learn and experiment better. The PDS utilizes machine learning algorithms such as Decision Tree (DT), Random Forest (RF), and Naive Bayes (NB), along with their combination, to classify dengue fever and its types. The dataset used in this study consisted of 400 records of 15 attributes, and the data was preprocessed to reduce noise, incompleteness and inconsistencies. The classification results showed that the PDS achieved an average accuracy of 95.6%, with the highest individual accuracy achieved by RF, DT and NB being 98%, 97% and 87% respectively. Our results demonstrate that PDS can facilitate the diagnostic process in resource-limited settings by providing an alternative to hardware-intensive solutions. Furthermore, the system can aid healthcare professionals in making early and accurate diagnoses, and can also serve as a learning tool for new staff.