bluuebunny/crossref_metadata_2025_split huggingface dataset:
A fixed point result on an extended neutrosophic rectangular metric space with application
Authors: Mani Gunaseelan , Antony Maria A. R. M. , Mitrović Zoran D. , Aloqaily Ahmad , Mlaiki Nabil 
Published: January 2024

AbstractIn this paper, we propose the notion of extended neutrosophic rectangular metric space and prove some fixed point results under contraction mapping. Finally, as an application of the obtained results, we prove the existence and uniqueness of the Caputo fractional differential equation.
City-scale heating and cooling with aquifer thermal energy storage (ATES)
Authors: Stemmle Ruben , Lee Haegyeong , Blum Philipp , Menberg Kathrin 
Published: January 2024

AbstractSustainable and climate-friendly space heating and cooling is of great importance for the energy transition. Compared to conventional energy sources, Aquifer Thermal Energy Storage (ATES) systems can significantly reduce greenhouse gas emissions from space heating and cooling. Hence, the objective of this study is to quantify the technical potential of shallow low-temperature ATES systems in terms of reclaimable energy in the city of Freiburg im Breisgau, Germany. Based on 3D heat transport modeling, heating and cooling power densities are determined for different ATES configurations located in an unconsolidated gravel aquifer of varying hydrogeological subsurface characteristics. High groundwater flow velocities of up to 13 m d−1 cause high storage energy loss and thus limit power densities to a maximum of 3.2 W m−2. Nevertheless, comparison of these power densities with the existing thermal energy demands shows that ATES systems can achieve substantial heating and cooling supply rates. This is especially true for the cooling demand, for which a full supply by ATES is determined for 92% of all residential buildings in the study area. For ATES heating alone, potential greenhouse gas emission savings of up to about 70,000 tCO2eq a−1 are calculated, which equals about 40% of the current greenhouse gas emissions caused by space and water heating in the study areas’ residential building stock. The modeling approach proposed in this study can also be applied in other regions with similar hydrogeological conditions to obtain estimations of local ATES supply rates and support city-scale energy planning.
Trends and challenges of fruit by-products utilization: insights into safety, sensory, and benefits of the use for the development of innovative healthy food: a review
Authors: Hasan Md. Mehedi , Islam Md. Rakibul , Haque Ahmed Redwan , Kabir Md. Raihan , Khushe Khursheda Jahan , Hasan S. M. Kamrul 
Published: January 2024

AbstractA significant portion of the human diet is comprised of fruits, which are consumed globally either raw or after being processed. A huge amount of waste and by-products such as skins, seeds, cores, rags, rinds, pomace, etc. are being generated in our homes and agro-processing industries every day. According to previous statistics, nearly half of the fruits are lost or discarded during the entire processing chain. The concern arises when those wastes and by-products damage the environment and simultaneously cause economic losses. There is a lot of potential in these by-products for reuse in a variety of applications, including the isolation of valuable bioactive ingredients and their application in developing healthy and functional foods. The development of novel techniques for the transformation of these materials into marketable commodities may offer a workable solution to this waste issue while also promoting sustainable economic growth from the bio-economic viewpoint. This approach can manage waste as well as add value to enterprises. The goal of this study is twofold based on this scenario. The first is to present a brief overview of the most significant bioactive substances found in those by-products. The second is to review the current status of their valorization including the trends and techniques, safety assessments, sensory attributes, and challenges. Moreover, specific attention is drawn to the future perspective, and some solutions are discussed in this report.
Association between dietary antioxidants intake and childhood eczema: results from the NHANES database
Authors: Xu Jing , Li Hongxin 
Published: January 2024

Abstract
Background
High dietary intake of antioxidants reduces the risk of allergic sensitization in children. However, there was no sufficient evidence for the effect of dietary antioxidants intake on childhood eczema. Herein, this study aimed to explore the roles of different dietary antioxidants in childhood eczema.

Methods
Data of 2305 children and adolescents aged < 18 years old were extracted from the National Health and Nutrition Examination Survey database in 2005–2006 in this cross-sectional study. The associations between dietary antioxidants intake and childhood eczema were explored using univariate and multivariate logistic regression analyses, with odds ratios (ORs) and confidence intervals (CIs). Subgroup analyses based on age and gender were also performed.

Results
A total of 268 (11.6%) children had eczema. After adjusting for covariates, we found no significant associations between dietary intake of β-carotene, vitamin C, selenium (Se), and retinol and childhood eczema. However, compared with children and adolescents whose dietary zinc (Zn) intake < 7.47 mg, those who had dietary Zn intake level ≥ 11.83 mg seemed to have lower odds of eczema [OR 0.45, 95% CI 0.28–0.73]. In addition, subgroup analysis showed that especially in children and adolescents aged 1–11 years old, whatever the gender, a higher dietary intake level of Zn may benefit childhood eczema (all P < 0.05).

Conclusion
We concluded dietary Zn intake was negatively associated with childhood eczema. Further studies are needed to explore the roles of dietary antioxidants intake in childhood eczema.
Outcomes after stenting of renal artery stenosis in patients with high-risk clinical features
Authors: Homorodean Calin , Ober Mihai Claudiu , Spinu Mihail , Olinic Maria , Tataru Dan-Alexandru , Onea Horea Laurentiu , Achim Alexandru , Lazar Leontin Florin , Homorodean Romana , Deak Balasz , Olinic Dan Mircea 
Published: January 2024

Abstract
Background
In patients with renal artery stenosis, revascularization was seen as a mean to improve outcomes, but large studies failed to show significant benefit in general population. However, data on benefits of renal artery stenting in patients with high-risk features, such as rapidly declining renal function and cardiac destabilization syndromes, are limited, as they were excluded from trials. In this descriptive study, we aimed to evaluate short- and long-term outcomes in high-risk patients with renal artery stenosis, treated by angioplasty and stenting. We have retrospectively interrogated our local databases for renal artery percutaneous interventions; patients at high-risk (rapidly declining renal function; stable chronic renal failure and bilateral renal artery disease; severe hypertensive crisis) were selected for the current analysis.

Results
Of 30 patients undergoing renal artery stenting, 18 patients were deemed "high-risk." On short term, good in-hospital control of hypertension and cardiac stabilization were obtained in all patients. Renal function improved significantly only in patients admitted with rapidly declining renal function, with significant creatinine level fall from median 3.98 mg/dL to 2.02 mg/dL, p = 0.023. However, for the whole group, creatinine change was non-significant (− 0.12 mg/dL, p = NS). On the long term, five patients (27.8%) ended-up on chronic hemodialysis and six patients died (33.3%) after a median of 20 months. No death occurred during the first year after the procedure.

Conclusions
Percutaneous procedures are feasible and safe in patients with high-risk renal artery stenosis, especially in those with rapidly declining renal function, probably saving some of them from the immediate need for renal replacement therapy, but long-term results are negatively influenced by the precarious general and cardio-vascular status of these patients and by the pre-existing significant renal parenchymal disease, non-related to the renal artery stenosis.
Molecular characterization of the camel nasal botfly, Cephalopina titillator (Diptera: Oestridae)
Authors: Shaalan Mona G. , Farghaly Sherif Hamed , Khater Emad I. , Kenawy Mohamed A. , Ghallab Enas Hamdy 
Published: January 2024

Abstract
Background
Larval stages of the camel nasal botfly, Cephalopina titillator (Diptera: Oestridae), rank among the top obligate endoparasites causing nasopharyngeal myiasis. Such infestations have adverse effects on camel health, reducing their economic value. The current study’s objective is to assess the applicability of PCR using partial regions of the COI mtDNA and 28S rRNA gene sequences to identify, classify, and reveal the phylogenesis of C. titillator.

Results
Larvae of the 2nd and 3rd instars of C. titillator were collected from the El-Bassatin abattoir in Egypt, extracted from the nasopharyngeal passage of the Arabian camel (Camelus dromedarius) during postmortem inspection. Genomic DNA was successfully isolated from 10 samples of 3rd instar larvae of C. titillator and amplified using primer pairs targeting partial mitochondrial COI (916 bp) and ribosomal 28S rRNA (830 bp) gene fragments. Nucleotide sequences from five samples have been sequenced and submitted to GenBank under accession numbers OP482168 to OP482172 for the COI gene and OP482160 to OP482164 for the 28S rRNA gene fragments. The COI gene exhibited 97.3% nucleotide identity across all specimens, while the 28S rRNA gene displayed 99.74% identical nucleotides. Maximum likelihood trees were constructed based on the generalized time-reversible (GTR) model. The resulting COI phylogenetic tree demonstrated that the subfamily Oestrinae does not exhibit monophyly. Additionally, it revealed that C. titillator is a sister group to the subfamily Gasterophilinae. Despite the scarcity of data available for the 28S rRNA gene, the phylogenetic analysis utilizing 28S rRNA revealed one distinct lineage for the Egyptian camel nasal bot fly.

Conclusions
Molecular phylogenetic analysis was conducted using molecular markers of distinct origins (both mitochondrial and nuclear) to elucidate the evolutionary relationships within the family Oestridae. This analysis is particularly significant following the inclusion of C. titillator, a first-time discovery in Egypt.
Acceptability of Integrated Community-Based HIV and Cervical Cancer Screening in Mayuge District, Uganda
Authors: Mezei Alex , Trawin Jessica , Payne Beth , Rawat Angeli , Naguti Priscilla , Orem Jackson , Murray Melanie C.M. , Nakisige Carolyn , Ogilvie Gina 
Published: January 2024

PURPOSE To assess the acceptability of integrated screening for cervical cancer and HIV in the community setting. METHODS We developed surveys for patients and community health workers (CHWs) who participated in the Advances in Screening and Prevention in Reproductive Cancers (ASPIRE) Mayuge trial that compared self-collected human papillomavirus testing at home versus community health meetings in Mayuge district, Uganda. Quantitative data were summarized using descriptive statistics. Open-ended questions were analyzed using an inductive approach with thematic content analysis. RESULTS We conducted 102 patient surveys and 31 CHW surveys between June and August 2021. Ninety-nine percent of patients and 100% of CHWs indicated that they would find the addition of an HIV test to their self-collected cervical cancer test acceptable. The most frequently stated reasons in favor of adding an HIV test to the ASPIRE Mayuge cervical cancer screening pathways were time-saving, privacy, and support from other women and CHWs. The most frequently stated reasons against integrated screening were related to concerns about confidentiality, most often in reference to women's family members and other women in their village. CONCLUSION Integrated community-based cervical cancer and HIV testing would be highly acceptable to both women and CHWs.
Pilot Study of a Mobile Phone Chatbot for Medication Adherence and Toxicity Management Among Patients With GI Cancers on Capecitabine
Authors: Lau-Min Kelsey S. , Marini Jessica , Shah Nishant K. , Pucci Donna , Blauch Abigail N. , Cambareri Christine , Mooney Bethany , Agarwal Parul , Johnston Caleb , Schumacher Ryan P. , White Kyle , Gabriel Peter E. , Rosin Roy , Jacobs Linda A. , Shulman Lawrence N. 
Published: January 2024

PURPOSE Capecitabine is an oral chemotherapy used to treat many gastrointestinal cancers. Its complex dosing and narrow therapeutic index make medication adherence and toxicity management crucial for quality care. METHODS We conducted a pilot study of PENNY-GI, a mobile phone text messaging–based chatbot that leverages algorithmic surveys and natural language processing to promote medication adherence and toxicity management among patients with gastrointestinal cancers on capecitabine. Eligibility initially included all capecitabine-containing regimens but was subsequently restricted to capecitabine monotherapy because of challenges in integrating PENNY-GI with radiation and intravenous chemotherapy schedules. We used design thinking principles and real-time data on safety, accuracy, and usefulness to make iterative refinements to PENNY-GI with the goal of minimizing the proportion of text messaging exchanges with incorrect medication or symptom management recommendations. All patients were invited to participate in structured exit interviews to provide feedback on PENNY-GI. RESULTS We enrolled 40 patients (median age 64.5 years, 52.5% male, 62.5% White, 55.0% with colorectal cancer, 50.0% on capecitabine monotherapy). We identified 284 of 3,895 (7.3%) medication-related and 13 of 527 (2.5%) symptom-related text messaging exchanges with incorrect recommendations. In exit interviews with 24 patients, participants reported finding the medication reminders reliable and user-friendly, but the symptom management tool was too simplistic to be helpful. CONCLUSION Although PENNY-GI provided accurate recommendations in >90% of text messaging exchanges, we identified multiple limitations with respect to the intervention's generalizability, usefulness, and scalability. Lessons from this pilot study should inform future efforts to develop and implement digital health interventions in oncology.
Effects of a Cycling versus Running HIIT Program on Fat Mass Loss and Gut Microbiota Composition in Men with Overweight/Obesity
Authors: COUVERT ANNAËLLE , GOUMY LESLIE , MAILLARD FLORIE , ESBRAT ALEXANDRE , LANCHAIS KASSANDRA , SAUGRAIN CÉLIA , VERDIER CHARLOTTE , DORÉ ERIC , CHEVARIN CAROLINE , ADJTOUTAH DJAMEL , MOREL CLAIRE , PEREIRA BRUNO , MARTIN VINCENT , LANCHA ANTONIO H. , BARNICH NICOLAS , CHASSAING BENOÎT , RANCE MÉLANIE , BOISSEAU NATHALIE 
Published: January 2024

ABSTRACT

Purpose
High-intensity interval training (HIIT) can efficiently decrease total and (intra-)abdominal fat mass (FM); however, the effects of running versus cycling HIIT programs on FM reduction have not been compared yet. In addition, the link between HIIT-induced FM reduction and gut microbiota must be better investigated. The aim of this study was to compare the effects of two 12-wk HIIT isoenergetic programs (cycling vs running) on body composition and fecal microbiota composition in nondieting men with overweight or obesity.

Methods
Sixteen men (age, 54.2 ± 9.6 yr; body mass index, 29.9 ± 2.3 kg·m−2) were randomly assigned to the HIIT-BIKE (10 × 45 s at 80%–85% of maximal heart rate, 90-s active recovery) or HIIT-RUN (9 × 45 s at 80%–85% of maximal heart rate, 90-s active recovery) group (3 times per week). Dual-energy x-ray absorptiometry was used to determine body composition. Preintervention and postintervention fecal microbiota composition was analyzed by 16S rRNA gene sequencing, and diet was controlled.

Results
Overall, body weight, and abdominal and visceral FM decreased over time (P < 0.05). No difference was observed for weight, total body FM, and visceral FM between groups (% change). Conversely, abdominal FM loss was greater in the HIIT-RUN group (−16.1% vs −8.3%; P = 0.050). The α-diversity of gut microbiota did not vary between baseline and intervention end and between groups, but was associated with abdominal FM change (r = −0.6; P = 0.02). The baseline microbiota profile and composition changes were correlated with total and abdominal/visceral FM losses.

Conclusions
Both cycling and running isoenergetic HIIT programs improved body composition in men with overweight/obesity. Baseline intestinal microbiota composition and its postintervention variations were correlated with FM reduction, strengthening the possible link between these parameters. The mechanisms underlying the greater abdominal FM loss in the HIIT-RUN group require additional investigations.
Running 40 Minutes under Temperate or Hot Environment Does Not Affect Operating Fascicle Length
Authors: MORNAS ADÈLE , BROCHERIE Franck , HOLLVILLE Enzo , DEROUCK Thomas , RACINAIS SÉBASTIEN , GUILHEM GaËL 
Published: January 2024

ABSTRACT

Purpose
Muscle mechanics is paramount in our understanding of motor performance. However, little is known regarding the sensitivity of fascicle dynamics and connective tissues stiffness to exercise duration and ambient temperature during running, both increasing muscle temperature. This study aimed to determine gastrocnemius medialis (GM) fascicle dynamics in vivo during running in temperate and hot conditions, as well as muscle–tendon unit responses.

Methods
Using ultrafast ultrasound, 15 participants (8 men, 7 women; 26 ± 3 yr) were tested before, during (2 and 40 min), and after a running task (40 min at 10 km·h−1) in temperate (TEMP; ~23°C) and hot (HOT: ~38°C) conditions.

Results
Although core, skin temperatures, and heart rate increased from the beginning to the end of the exercise and in a larger extent in HOT than TEMP (P < 0.001), the physiological stress elicited did not alter running temporal parameters and GM fascicle operating lengths, with similar behavior of the fascicles on their force–length relationship, over time (2 vs 40 min) or across condition (TEMP vs HOT; P ≥ 0.248). Maximal voluntary force production did not reported statistical changes after exercise (P = 0.060), and the connective tissues stiffness measured (i.e., passive muscle and stiffness of the series-elastic elements) did not show neither time (P ≥ 0.281), condition (P ≥ 0.256) nor time–condition interaction (P ≥ 0.465) effect.

Conclusions
This study revealed that prolonged running exercise does not alter muscle–tendon unit properties and interplay, which are not influenced by ambient temperature. These findings may rule out potential detrimental effects of heat on muscle properties and encourage further investigations on longer and more intense running exercise.
The Effect of an Early Life Motor Skill Intervention on Physical Activity in Growth-Restricted Mice
Authors: Leszczynski Eric C. , Thorn Megan E. , Szlachetka Josie , Lee Mei-Hua , Ferguson David P. 
Published: January 2024

ABSTRACT

Introduction
Early life growth-restriction significantly increases the risk of adulthood physical inactivity and thereby chronic disease incidence. Improvements in motor skill acquisition could result in greater physical activity engagement in the growth-restricted population thus reducing chronic disease risk. The purpose of this study was to implement an early life motor training intervention to improve physical activity engagement in control and growth-restricted mice.

Methods
Mice were growth-restricted in early life utilizing a validated nutritive model or remained fully nourished in early life as a control. All mice were tested throughout early life for various components of motor skill acquisition. On postnatal day 10, mice were randomly assigned to engage in an early life motor skill intervention daily until postnatal day 21 or remained as a sedentary control. All mice were given access to an in-cage running wheel from postnatal days 45-70.

Results
PGR mice had impaired trunk and postural control, coordination/vestibular development, and hindlimb strength in early life compared to control mice. There were no differences in wheel running behavior between the trained and sedentary mice, although control mice ran at a faster average speed compared to PGR mice. Control female mice ran more than PGR female mice during the week 2 dark cycle.

Conclusions
Early life growth-restriction reduced motor skill attainment throughout early life, which may be associated with reduced ability to engage in physical activity in adulthood. The early life motor skill intervention did not elicit changes in body weight or physical activity engagement in control or PGR mice, indicating a more intense/different intervention specifically targeting skeletal muscle may be necessary to counteract the detrimental effects of early life growth-restriction.
Reforma modelu rad narodowych czy ustanowienie samorządu terytorialnego? Samorządowe dyskusje w schyłkowym okresie PRL (1980–1989)
Authors: Radomski Grzegorz , Szczepański Dominik 
Published: January 2024

Celem podjętych rozważań była analiza dyskusji dotyczących samorządu, a w szczególności samorządu terytorialnego, prowadzonych na łamach oficjalnych publikacji ukazujących się w okresie PRL. Zakres czasowy obejmował okres od powstania „Solidarności” w 1980 r. do rozmów okrągłego stołu, w których dyskusje toczyły się najpierw w zespole ds. reform politycznych, a następnie powołano podstolik do spraw samorządu terytorialnego, nie uwzględniając jednak tego ostatniego wydarzenia.
Celem poznawczym było poszukiwanie odpowiedzi na następujące pytania badawcze: 1) dlaczego idea samorządu terytorialnego, zwłaszcza w drugiej połowie lat 80. XX w., a więc w okresie wyczerpywania się ówczesnego modelu państwa, nie zainteresowała w większym stopniu środowisk decyzyjnych i w konsekwencji nie doprowadziła do szerszej dyskusji? 2) jak środowiska opiniotwórcze rozumiały pojęcie samorządu terytorialnego? 3) jakie prezentowano wizje związane z odbudową samorządu terytorialnego? 4) jaki zakres, kompetencje i jaką rolę przewidywano dla tej instytucji? 5) czy wizje te określały sposób finansowania samorządu terytorialnego? oraz 6) czy w związku z zakładanymi dyskusjami podjęto również przekształcenie systemu wyborczego?
Ordensritter und Frauen in Livland im 16. Jahrhundert
Authors: Kreem Juhan 
Published: January 2024

The Teutonic Knights and Women in the 16th century Livonia

Amount of information on women in the castles of the Teutonic Order in Livonia is scarce. From the 16th century there is evidence about the female housekeepers (low-ger. mayersche) in the manors and smaller castles of the commandery of Fellin. The artisans and servants of the Order were not bound to the vow of celibacy, some of them certainly had families and lived in the castles.
The knights in Livonia participated in worldly activities such as weddings in the sixteenth century. Moreover, in some cases it could be shown that the knights were organizers of these events. This involved not only initial match-making but also guiding through the actual event as well. On these occasions it can be shown, how deeply the knights were involved in organizing the family affairs of their relatives: be that the guardianship of a mother or betrothal of a sister. Female relatives of the knights sometimes also visited Livonia.
Several critics of the Order also single out the concubines of the brethren. The number of knights, who are known to have had concubines in the sixteenth century is not small. We do not know much about the forms of the relationships or eventual cohabitation. Most of the information is on the children born of these relationships, whose subsistence was taken care of.