bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 25 — Remitting Seronegative Symmetric Synovitis with Pitting Edema (RS3PE) in Dialysis Patient
Authors: AlKindi Fatima , AlBashir Nihal , Chaaban Ahmad , George Abraham , Saad Mohamed , Hakim Mohammad Al , Budruddin Mohammed , Khan Imran , Boobes Yousef 
Published: November 2023

Background Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is characterized by acute symmetrical synovitis, and pitting edema involving, the dorsal part of hands and feet. It affects more men aged more than 50 years. The inflammatory markers are usually elevated, with negative rheumatoid factor. The underlying etiology is not clear but has been associated with drugs exposure, infections, malignancy in 30% of cases, and coexist with other autoimmune diseases. The clinical course is benign with significant improvement to low-dose prednisolone therapy for 2 to 3 months. It has been rarely reported in dialysis patients. Methods and case description A 54 years old male, known to have long standing uncontrolled diabetes mellitus, hypertension, chronic kidney disease and diabetic retinopathy. Recently, he was treated for left foot cellulitis and advanced renal failure (813 micromol/L) initiated on hemodialysis. He presented one week later with progressive painful bilateral upper limb and lower limb pitting edema, with limited range of movement in hands and reduce urine output. He was resumed on hemodialysis for management of volume overload. Despite removal of almost 12 liters of fluids during consecutive dialysis sessions and improvement of lower limb edema, his bilateral hand edema was persistence with pain and limited movement. Further investigations were done to evaluate for rheumatological condition. Results Hand X ray was normal and ultrasound of the hand revealed features of synovitis, diffuse subcutaneous oedema and possible cellulitis. He was started on IV antibiotics without major improvement and blood culture was negative. CT chest showed left pleural effusion. The ESR was elevated 120, while serology for HBV. HCV, HIV, and parvovirus were negative. In addition, the autoimmune workup were negative (CCP, RF, ANA, ANCA, C3, C4, ACEI). He was diagnosed with remitting seronegative symmetric synovitis with pitting edema (RS3PE). He was treated with IV hydrocortisone once 100 mg, followed by oral prednisolone 10 mg for 5 days with dramatic improvement in bilateral hand edema and movement. He had hyperglycemia steroid related managed with adjustment of insulin therapy. At follow up in 1 week, patient regain full function of both hands, and he was on regular hemodialysis trice per week. Conclusion RS3PE is rare in hemodialysis patients, with favorable response to steroid therapy. We used shorter duration of 5 days steroid therapy with complete recovery and no recurrence at 1 year follow up. Screening for underlying autoimmune, infection or malignancy in RS3PE is essential.
Scalable and Accelerated Self-healing Control Circuit Using Evolvable Hardware
Authors: S. Deepanjali , Mahammad SK Noor 
Published: November 2023

Controllers are mission-critical components of any electronic design. By sending control signals, they decide which and when other data path elements must operate. Faults, especially Single Event Upset (SEU) occurrence in these components, can lead to functional/mission failure of the system when deployed in harsh environments. Hence, competence to self-heal from SEU is highly required in the control path of the digital system. Reconfiguration is critical for recovering from a faulty state to a non-faulty state. Compared to native reconfiguration, the Virtual Reconfigurable Circuit (VRC) is an FPGA-generic reconfiguration mechanism. The non-partial reconfiguration in VRC and extensive architecture are considered hindrances in extending the VRC-based Evolvable Hardware (EHW) to real-time fault mitigation. To confront this challenge, we have proposed an intrinsic constrained evolution to improve the scalability and accelerate the evolution process for VRC-based fault mitigation in mission-critical applications. Experimentation is conducted on complex ACM/SIGDA benchmark circuits and real-time circuits used in space missions, which are not included in related works. In addition, a comparative study is made between existing and proposed methodologies for brushless DC motor control circuits. The hardware utilization in the multiplexer has been significantly reduced, resulting in up to a 77% reduction in the existing VRC architecture. The proposed methodology employs a fault localization approach to narrow the search space effectively. This approach has yielded an 87% improvement on average in convergence speed, as measured by the evolution time, compared to the existing work.
Assessment of indicators of bone tissue resorption in patients with chronic generalized periodontitis according to the data of cone-beam computer tomography
Authors: Hasiuk Р. A. , Korobeinikova Yu. L. , Piasetska L. V. , Korobeinikov L. S. , Demkovych A. Ye. , Kalashnikov D. V. , Zubchenko S. G. 
Published: November 2023

Summary. One of the criteria for assessing the degree of pathological changes in periodontal tissues is resorption of the bone tissue of the alveolar process of the jaw. However, changes from the vestibular and oral surfaces on a panorama or focused intraoral x-rays are covered by the shadow of the teeth and objectively do not provide an opportunity for accurate diagnosis of pathological changes in periodontal tissues. The only technique that makes it possible to obtain a three-dimensional image of the studied area with minimal exposure is cone-beam computed tomography (CBCT).
The aim of this study – to evaluate bone tissue resorption in the area of frontal teeth of patients with chronic generalized periodontitis according to CBCT data.
Materials and Methods. The study analyzed the resorption of bone tissue in the area of frontal teeth (80 teeth) in patients with chronic generalized periodontitis. The average age of the subjects was 34–44 years. The EzD2009 software and the basic interface to work in the main MPR (multiplenar reformation) option – multiplenar visualization of a three-plane image was used for CBCT analysis, with adjustment of the thickness of the selected layer (TH) from 0.03 mm to 3.0 cm.
Results and Discussion. The results of cone-beam computed tomography revealed a significant difference in the bone resorption rates of the alveolar process of the jaw from the medial, distal, and vestibulo-oral sides.
Conclusions. This indicates that a detailed study of this indicator is an essential factor in the diagnosis of periodontal changes in patients with chronic generalized periodontitis.
Порівняльна оцінка діагностичних методів визначення розмірів (площі) стравохідного отвору діафрагми у хворих із параезофагеальною грижею
Authors: ІОФФЕ О. Ю. , ТАРАСОВ Т. А. 
Published: November 2023

Мета роботи: порівняти площу стравохідного отвору діафрагми у хворих із параезофагеальними грижами ІІІ типу за даними доопераційного та інтраопераційного вимірювань.
Матеріали і методи. У хірургічній клініці Національного медичного університету впродовж 2016–2021 р. проведено вимірювання площі стравохідного отвору діафрагми у 63 хворих з параезофагеальними грижами ІІІ типу за допомогою мультиспіральної комп’ютерної томографії, езофагогастрофіброскопії та інтраопераційно під час виконання планової лапароскопічної герніо­пластики (за методом Granderath та визначення площі ромбу). Серед хворих було 41,3 % чоловіків та 58,7 % жінок, середній вік становив (53,8±10,8) року і ІМТ (29,6±4,9) кг/м2.
Результати досліджень та їх обговорення. Встановлено сильний зв’язок між значеннями мультиспіральної комп’ютерної томографії та іншими методами: з езофагогастрофіброскопії – лінійний R2=0,843, з методикою Granderath – R2=0,872, з методикою визначення площі ромбу –R2=0,778. Водночас величини площі стравохідного отвору діафрагми виявили певну відмінність залежно від застосованого методу.
Найбільше середнє значення площі стравохідного отвору діафрагми порівняно з іншими методиками (всі p<0,01) отримано за даними мультиспіральної комп’ютерної томографії – (13,01±3,04) см3 (від 8,4 см3 до 29,1 см2). Причому площа стравохідного отвору діафрагми, за даними мультиспіральної комп’ютерної томографії, виявилася більшою порівняно з іншими методиками у кожного хворого. Зокрема, її результати перевищували такі отримані за методикою Granderath в середньому на (33,2±5,1) % (від 15 % до 54 %).
Найменше середнє значення площі стравохідного отвору діафрагми отримано при езофагогастрофіброскопії – (7,88±1,63) см2 (від 5,2 до 15,2 см2), яке достовірно відрізнялося від такої, виміряної за методикою визначення площі ромбу – (8,72±1,67) см2 (від 5,8 до 15,4 см2), та статистично не відрізнялося за показниками, отриманими за методикою Granderath – (8,16±1,71) см2 (від 5,8–16,3 см2). Середні значення площі стравохідного отвору діафрагми за інтраопераційними методиками статистично не відрізнялися (р>0,05).
Середні значення площі стравохідного отвору діафрагми у хворих із параезофагеальними грижами ІІІ типу відрізняються залежно від застосованої методики вимірювання: найбільше отримано за даними мультиспіральної комп’ютерної томографії – (13,01±3,04) см3, найменше – при езофагогастрофіброскопії – (7,88±1,63) см2. Середні значення площі стравохідного отвору діафрагми при інтраопераційному вимірюванні: за Granderath (8,16±1,71) см2 та за методикою визначення площі ромбу (8,72±1,67) см2 статистично не відрізнялися.
ЗМІНИ ПРОЦЕСІВ ПЕРОКСИДНОГО ОКИСНЕННЯ ЛІПІДІВ У КРОВІ ЩУРІВ-САМЦІВ, ЯКІ ЗАЗНАЛИ СТРЕСУ
Authors: Денефіль О. В. , Мозгова Є. В. , Ярошенко Т. Я. , Пришляк А. М. , Юріїв К. Є. 
Published: November 2023

Вступ. Стрес на сьогодні є однією з основних проблем сьогодення не тільки в Україні, але й у всьому світі. Щоправда, стрес призводить до ушкодження різних органів і систем не в усіх, у частини відбувається адаптація до нього. Вивчення впливу різних моделей стресу, зокрема з’ясування механізмів їх дії на організм, є актуальним.
Мета дослідження – оцінити активність процесів пероксидного окиснення ліпідів у крові щурів-самців, які зазнали стресу.
Методи дослідження. Досліди виконано на 48 білих щурах-самцях лінії Вістар віком 3,5–4 місяці. Їх поділили на чотири групи: 1-ша – контроль; 2-га – стрес 24 год 3 рази (Стрес 1); 3-тя – стрес 24 год 4 рази (Стрес 2); 4-та – стрес 72 год 4 рази (Стрес 3). Стрес викликали шляхом м’якої фіксації тканиною тварини на дощечці протягом 1 год спинкою донизу. В 2-й групі спричиняли стрес кожних 24 год 3 рази, у 3-й – кожних 24 год 4 рази, в 4-й – кожних 72 год 4 рази. У сироватці крові визначали супероксиддисмутазну (СОД) і каталазну (КАТ) активність, концентрацію дієнових, трієнових кон’югатів (ДК, ТК), основ Шиффа (ОШ), ТБК-активних продуктів (ТБК-ап).
Результати й обговорення. При Стресі 1, порівняно з контролем, зросли показники ДК, ТК, ОШ, ТБК-ап. Відмічено підвищення СОД і КАТ активності. При Стресі 2, порівняно з контролем, вміст ДК збільшився і не відрізнявся від значення тварин 2-ї групи. У цій групі щурів рівень ТК виявився вищим порівняно з контролем і був нижчим, ніж у 2-й групі. Вміст ОШ зріс та був більшим порівняно з 2-ю групою. Рівень ТБК-ап, порівняно з контролем, підвищився і був більшим, ніж у 2-й групі. Порівняно з контролем СОД активність не змінилася та була нижчою, ніж у 2-й групі, КАТ активність, порівняно з контролем, знизилася і була меншою, ніж у 2-й групі. При Стресі 3 вміст ДК, порівняно з контролем, зріс та був більшим, ніж у 2-й і 3-й групах. При Стресі 3 рівень ТК перевищував показники контролю, 2-ї і 3-ї груп. Вміст ОШ знизився та був меншим порівняно з 2-ю і 3-ю групами. Рівень ТБК-ап, порівняно з контролем, підвищився та був більшим, ніж у 2-й і 3-й групах. Порівняно з контролем СОД активність різко знизилася і була меншою, ніж у 2-й і 3-й групах, КАТ активність, порівняно з контролем, зросла та була більшою, ніж у 2-й і 3-й групах.
Висновки. При стресі, що повторюється тричі кожних 24 год, виникає адаптація тварин, при стресі, який повторюється 4 рази кожних 24 год, – їх дизадаптація, при стресі, що повторюється 4 рази кожних 72 год, – виснаження.
The Concept of Complexion in Antonio da Parma’s Medical Anthropology
Authors: Robert Aurélien 
Published: November 2023

Abstract
Antonio da Parma (d. 1327) was a philosopher and physician, active in Bologna in the early fourteenth century, and associated with so-called “Bolognese Averroism.” His philosophical works are increasingly better documented. While his medical works are much less studied, his commentary – written between 1310 and 1323 – on the first book of Avicenna’s Canon, had a considerable influence on later commentators. This paper presents his analysis of the notion of ‘complexion’, a notion central to his anthropology for the philosophical issues it seeks to address: the possibility, for example, of defining the specific nature of the human body – as compared with other natural species – or of conceiving a scientific and universal discourse when confronted with the extreme variability of individual bodily complexion, which is at the heart of medical practice. Taking from Galen and Avicenna their ‘relativistic’ analysis of the well-balanced complexion, Antonio uses the idea of a latitude of individual complexion within the limits set by the natural species, to thereby make this picture of the human body coherent with the principles of Aristotelian natural philosophy. In so doing, he addresses the relationship between matter and form in a human body, the individuation of human bodies, or the principle of identity of a singular body. The paper concludes with a transcription of the relevant passages from Antonio’s commentary on Avicenna’s Canon.
Gender consciousness and sun protection patterns among Chinese youth: A cross-sectional analysis
Authors: Li Jiaxing , Zhang Rui , Luo Yingyi , Na Lixin 
Published: November 2023

Objective: In contrast to previous research that has primarily focused on gender differences in health behaviour compliance, this study explored the association between gender consciousness and sun protection in China – a cultural setting in which there is a pronounced gender bias towards sun protection. These article is the first attempt to examine gender norms concerning sunscreen use among Chinese individuals, encompassing both young women and young men. Design and setting: Cross-sectional analysis conducted on one Chinese campus. Methods: Utilising data from the 2020 cohort of first-year students (549 male students and 1,489 female students) at a local university in Shanghai and employing OLS regression analysis, our analysis sheds light on gendered patterns of sun protection use among young individuals in China. Results: Findings reveal that gender attitudes affect women’s sun protection frequency without influencing their choice of specific products. Conversely, men’s gender conciousness shapes their sun protection methods but not their overall frequency of sun protection. In addition, despite lower aggregate levels of sun protection, young women exhibit higher heterogeneity in their responses than young men. Socioeconomic status, health awareness and gender consciousness are all significant factors influencing sun protection among female students; however, among men, only health awareness shows a positive correlation with the use of sun protection. Conclusion: The results of this study exhibit some differences from initial expectations, suggesting that the full adoption of sun protection measures is still a work in progress. However, despite the differences identified, findings provide valuable insights to inform future public health efforts to promote sun protection among youth.
Does the Miniscrew Length, Insertion Level, and Insertion Force Make a Difference on the Stress and Strain Distribution Across the Alveolar Bone? A Finite Element Study
Authors: Marya Anand , Eugenio Matthew Angelo Mina , Venugopal Adith , Gandedkar Narayan , Mesgarzadeh Nasim 
Published: November 2023

Objective The aim of this study was to evaluate, using the finite element method (FEM), the stresses generated on various parts of the mini-screw and on the bone resulting from the insertion of mini-screws of varying lengths and under different forces. Materials and Methods Three-dimensional models of mini-screws (1.6 × 6, 8, and 10 mm) and bone (mandible cortical bone thickness of 2 mm) were constructed and simulated using FEM. The mini-screws were inserted using force loads of 10 and 20 Ncm, and stress evaluation was carried out on screws and bone. The stress evaluation was also performed across different levels of insertion (at the point of insertion, half-insertion, and full insertion). Results A direct correlation between the force applied and the stresses on the body of the screws was observed. There was an inverse relationship between the length of the mini-screw and the resulting stress on the bone with the highest stress of 14.58 Mpa with 6 mm long and the minimum stress of 3.81 Mpa with longer mini-screws. On application of different force magnitudes, the stress levels increased linearly with a change in the length. The highest stresses on the bone were observed only when the screw was fully inserted in the bone. Conclusion When mini-screws of different lengths were inserted using different magnitudes of forces, the stress levels increased linearly on the bone. A combination of longer mini-screw and lesser force magnitude used during insertion produced less stress on the bone.
Identification of key proteins as potential biomarkers associated with post-infarction complications in diabetics
Authors: Wu Wei , Yan Li , Yuan Xiao-Fei , Wang Lu , Zhang Yu , Tu Rong-xiang , Pan Jiang-Qi , Yin Lu , Ge Zhi-Ru 
Published: November 2023

Background: The ability of transcriptome analysis to identify dysregulated pathways and outcome-related genes following myocardial infarction in diabetic patients remains unknown. The present study was designed to detect possible biomarkers associated with the incidence of post-infarction complications in diabetes to assist thedevelopment of novel treatments for this condition. Methods: Two gene expression datasets, GSE12639 and GSE6880, were downloaded from the Gene Expression Omnibus (GEO) database, and then differentially expressed genes (DEGs) were identified between post-infarction diabetics and healthy samples from the left ventricular wall of rats. These DEGs were then arranged into a protein–protein interaction (PPI) network, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) enrichment analyses were performed to explore the functional roles of these genes. Results: In total, 30 DEGs (14 upregulated and 16 downregulated) were shared between these two datasets, as identified through Venn diagram analyses. GO analyses revealed these DEGs to be significantly enriched in ovarian steroidogenesis, fatty acid elongation, biosynthesis of unsaturated fatty acids, synthesis and degradation of ketone bodies, and butanoate metabolism. The PPI network of the DEGs had 14 genes and 70 edges. We identified two key proteins, 3-hydroxymethylglutaryl-CoA synthase 2 (Hmgcs2) and Δ3, Δ2-Enoyl-CoA Delta Isomerase 1 (ECI1), and the upregulated gene Hmgcs2 with the highest score in the MCC method. We generated a co-expression network for the hub genes and obtained the top ten medications suggested for infarction with diabetes. Conclusion: Taken together, the findings of these bioinformatics analyses identified key hub genes associated with the development of myocardial infarction in diabetics. These hub genes and potential drugs may become novel biomarkers for prognosis and precision treatment in the future.
Discovering KYNU as a feature gene in hidradenitis suppurativa
Authors: Liang Chen , Yu Yue , Tang Qinyu , Shen Liangliang 
Published: November 2023

Background Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin condition characterized by nodules, abscesses, and fistulae in skin folds. The underlying pathogenesis of HS remains unclear, and effective therapeutic drugs are limited. Methods We acquired mRNA expression profiles from the Gene Expression Omnibus (GEO) database and conducted differential expression analysis between control and HS samples using R software. Four machine learning algorithms (SVM, RF, ANN, and lasso) and WCGNA were utilized to identify feature genes. GO, KEGG, Metascape, and GSVA were utilized for the enrichment analysis. CIBERSORT and ssGSEA were employed to analyze immune infiltration. Results A total of 29 DEGs were identified, with the majority showing up-regulation in HS. Enrichment analysis revealed their involvement in immune responses and cytokine activities. KEGG analysis highlighted pathways such as IL-17 signaling, rheumatoid arthritis, and TNF signaling in HS. Immune infiltration analysis revealed the predominant presence of neutrophils, monocytes, and CD8 T cells. Machine learning algorithms and WCGNA identified KYNU as a feature gene associated with HS. We have also identified 59 potential drugs for HS based on the DEGs. Additionally, ceRNA network analysis identified the MUC19_hsa-miR-382-5p_KYNU pathway as a potential regulatory pathway. Conclusions KYNU emerged as a feature gene associated with HS, and the ceRNA network analysis identified the MUC19_hsa-miR-382-5p_KYNU pathway as a potential regulator.
A Qualitative Investigation on Chronic Disease Management and Prevention Among Older Adults During the COVID-19 Pandemic
Authors: Yang Michelle C. , Clayton Cam , Harris Devin , Pelletier Chelsea , Schmidt Julia , Zwicker Jill G. , Sakakibara Brodie M. 
Published: November 2023

Purpose To qualitatively describe experiences of chronic disease management and prevention in older adults (age ≥65 years) during COVID-19. Approach Qualitative descriptive approach. Setting Data collected online via telephone and video-conferencing technologies to participants located in various cities in British Columbia, Canada. Data analyzed by researchers in the cities of Vancouver and Kelowna in British Columbia. Participants Twenty-four community-living older adults (n = 24) age ≥65 years. Methods Each participant was invited to complete a 30-to-45-minute virtual, semi-structured, one-on-one interview with a trained interviewer. Interview questions focused on experiences managing health prior to COVID-19 and transitioning experiences of practicing health management and prevention strategies during COVID-19. Audio recordings of interviews were transcribed verbatim and analyzed thematically. Results The sample’s mean age was 73.4 years (58% female) with 75% reporting two or more chronic conditions (12.5% none, 12.5% one). Three themes described participants’ strategies for chronic disease management and prevention: (1) having a purpose to optimize health (i.e., managing health challenges and maintaining independence); (2) internal self-control strategies (i.e., self-accountability and adaptability); and (3) external support strategies (i.e., informational support, motivational support, and emotional support). Conclusion Helping older adults identify purposes for their own health management, developing internal control strategies, and optimizing social support opportunities may be important person-centred strategies for chronic disease management and prevention during unprecedented times like COVID-19.