bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Killer Lymphocytes Mediate Renal Fibrosis Due to Acute Cardiorenal Syndrome
Authors: Burfeind Kevin G. , Funahashi Yoshio , Munhall Adam C. , Eiwaz Mahaba , Hutchens Michael P. 
Published: December 2023

Key Points

Natural killer cells infiltrate the kidney after cardiac arrest and medial renal fibrosisGranzyme A is produced by natural killer cells and causes mesenchymal cell expansion and fibrosis in type 1 cardiorenal syndrome

Background
The AKI to CKD transition presents an opportunity for intervention to prevent CKD. Our laboratory developed a novel murine model of AKI-CKD transition and cardiac arrest/cardiopulmonary resuscitation (CA/CPR), in which all animals develop CKD at 7 weeks. The purpose of this study was to identify potential immune drivers of fibrosis after CA/CPR.

Methods
Cardiac arrest was induced by potassium chloride, and mice were resuscitated with chest compressions and epinephrine. The kidney immune landscape after CA/CPR was profiled using 11-color flow cytometry analysis and immunofluorescence. Immune cell-derived mediators of fibrosis were identified by analyzing data from three previously published single-cell or single-nuclear RNA sequencing studies. NRK49F fibroblasts were treated with granzyme A (GzA) in vitro, and then cell proliferation was quantified using 5-ethynyl-2′-deoxyuridine. GzA was pharmacologically inhibited both in vitro and in vivo.

Results
Immune cells infiltrated the kidney after CA/CPR, consisting primarily of innate immune cells, including monocytes/macrophages, neutrophils, and natural killer (NK) cells. NK cell infiltration immediately preceded mesenchymal cell expansion, which occurred starting 7 days after CA/CPR. Immune cells colocalized with mesenchymal cells, accumulating in the areas of fibrosis. Analysis of previously published single-cell or single-nuclear RNA sequencing data revealed GzA as a potential mediator of immune to mesenchymal communication. GzA administration to fibroblasts in vitro induced cell growth and proliferation. Pharmacologic blockade of GzA signaling in vivo attenuated fibrosis and improved renal function after CA/CPR.

Conclusions
Renal inflammation occurs during cardiorenal syndrome, which correlates with mesenchymal cell expansion. GzA, produced by NK cells, presents a novel therapeutic target to prevent the transition to CKD after AKI.
Screen Time dan Aktivitas Fisik dengan Asupan Energi Pada Remaja Obesitas
Authors: Islami Septi Nur , Yanti Rusmini , Hariati Niken Widyastuti 
Published: December 2023

Kota Banjarbaru memiliki prevalensi obesitas sebesar 3,60%, dan sudah mendekati nilai nasional yaitu 4,0%. Pola makan yang buruk, umur, aktivitas fisik, asupan energi, genetik, dan sedentary lifestyle merupakan faktor penyebab obesitas. Obesitas bisa terbentuk akibat kurangnya aktivitas fisik, disebabkan kebiasaan remaja yang hanya dilakukan aktivitas di dalam rumah, seperti kegiatan menatap layar. Penelitian ini bertujuan untuk mengetahui hubungan screen time dan aktivitas fisik dengan asupan energi pada remaja obesitas di SMK Negeri 1 Banjarbaru. Jenis penelitian ini adalah observasional analitik dengan rancangan cross- sectional. Sampel adalah siswa SMK Negeri 1 Banjarbaru yang mengalami obesitas sebanyak 45 orang. Pengumpulan data screen time, aktivitas fisik, dan asupan energi dengan wawancara kuesioner, dan dianalisis dengan menggunakan uji korelasi Rank Spearman. Hasil uji statistik Rank Spearman menunjukkan ada hubungan bermakna antara screen time dengan asupan energi (p-value= 0,005) dan ada hubungan antara aktivitas fisik (p-value = 0,000) dengan asupan energi remaja obesitas. Kesimpulan dari penelitian ini bahwa terdapat hubungan antara screen time dan aktivitas fisik dengan asupan energi pada remaja SMK Negeri 1 Banjarbaru.
Tingkat Kemandirian Lansia dalam Pemenuhan Activity Daily Living di Panti Sosial Tresna Wredha “AGAPE” Tondano
Authors: Runtu Andro Ruben , Enggune Meilita , Kaunang Djoise 
Published: December 2023

Kemandirian merupakan dimana sikap individu untuk bersikap mandiri dalam menghadapi berbagai situasi. Activity Daily Living (ADL) ialah tindakan menyelesaikan pekerjaan, jadwal, keseharian serta sebagai tindakan mendasar untuk merawat diri sendiri sehari- hari. Tujuan Penelitian ini untuk mengetahui bagaimana Tingkat Kemandirian Lansia dalam Pemenuhan Activity Daily Living (ADL) di Panti Sosial Tresna Wredha (PSTW) “AGAPE” Tondano. Penelitian ini menggunakan metode kuantitatif menggunakan desain deskriptif dengan teknik total sampling dan didapatkan 36 subjek. Pengumpulan data menggunakan koesioner dan dianalisis menggunakan univariat. Setelah dilakukan analisi data didapatkan ketegori mandiri yaitu sebanyak 34 subjek (94%), sedangkan yang memiliki kemandirian tergantung/dibantu sebanyak 2 subjek (6%). Oleh karena itu disimpulkan terdapat lansia yang memerlukan bantuan di Panti Sosial Tresna Wredha (PSTW) “AGAPE” Tondano. Saran perlu mempertahankan dan meningkatkan tingkat kemandirian lansia, sehingga dapat melakukan aktivitas secara mandiri dan memeriksakan kesehatan di fasilitas kesehatan yang ada.
Enduring association between irritable bowel syndrome and war trauma during the Nicaragua civil war period: A population-based study
Authors: Peña-Galo Edgar M , Wurzelmann Daniel , Alcedo Javier , Peña Rodolfo , Cortes Loreto , Morgan Douglas 
Published: December 2023

BACKGROUND
Psychosocial and physical trauma are known risk factors for irritable bowel syndrome (IBS), including in war veterans, whereas war exposure in civilians is unclear. Nicaragua experienced two wars, 1970-1990: The Sandinistas Revolution (1970s) and The Contra War (1980s). Our aim was to investigate the role of exposure to war trauma in the subsequent development of IBS in the context of an established health surveillance system (11000 households).
AIM
To investigate in a civilian population the relationship between exposure to war trauma and events and the subsequent development of IBS in the context of an established public health and demographic surveillance system in western Nicaragua.
METHODS
We conducted a nested population-based, cross-sectional study focused on functional gastrointestinal disorders based on Rome II criteria. 1617 adults were randomly selected. The Spanish Rome II Modular Questionnaire and Harvard Trauma Questionnaire were validated in Nicaragua. War exposure was assessed with 10 measures of direct and indirect war trauma and post-war effects. Multiple exposures were defined by ≥ 3 measures.
RESULTS
The prevalence of IBS was 15.2% [Female (F) 17.1%, Male (M) 12.0%], war exposure 19.3% (F 9.3%, M 36.7%), and post-traumatic stress disorder (PTSD) 5.6% (F 6.4%, M 4.3%). Significant associations with IBS in the civilian population were observed (adjusted by gender, age, socioeconomic status, education): physical and psychological abuse [adjusted odds ratio (aOR): 2.25; 95% confidence interval: 1.1-4.5], witnessed execution (aOR: 2.4; 1.1-5.2), family member death (aOR: 2.2; 1.2-4.2), and multiple exposures (aOR: 2.7; 1.4-5.1). PTSD was independently associated with IBS (aOR: 2.6; 1.2-5.7).
CONCLUSION
An enduring association was observed in the Nicaragua civilian population between specific civil war-related events and subsequent IBS. Civilian populations in regions with extended armed conflict may warrant provider education and targeted interventions for patients.
Perancangan E-Tajwid Berbasis Android Di RTQ (Rumah Tahfiz Qur’an) Raudhatul As Salimy Gobah Tilatang Kamang
Authors: Arianda Fried , Efriyanti Liza , Zakir Supratman , Khairuddin Khairuddin 
Published: December 2023

Abstract—This research is motivated by the lack of support for learning media in conveying recitation learning material. One effective and efficient way to increase interest in learning recitation is by designing an Android-based learning media. So that users, especially children aged 8 to 12, are able to read the Qur'an properly and correctly. Learning media for recitation are now available in several forms, including in the form of books, interactive CDs, and e-learning. Books have limitations that they can only display information in the form of text and images, are easily damaged by water or torn, and are difficult to carry around. The Interactive CD form has drawbacks for accessing it because you have to use computer media, the computer requires electrical power. The aspect of mobility is lacking because computers are not easy to carry everywhere. With the above constraints, we need a tool that will facilitate the process of learning to read the Qur'an. The tool meant here is the design of a mobile-based recitation learning media application
In designing this internship information system, researchers used DDD-E. Media development using the DDD-E model consists of (1) Decide or set program goals and materials, (2) Design or design, namely creating program structures, (3) Develop or developing is producing media elements and making media appearance, (4) Evaluate or evaluate, namely checking the entire design and development process. The resulting media were tested for the validity, practicality and effectiveness of the product using a questionnaire to assess the product aimed at media experts, teachers and students.
The results of the product test that the author did obtained a validity test from 1 validator obtained a value of 0.86 with a very valid category, a practicality test from 2 practicums obtained a value of 0.95 with a very high category, and the effectiveness test of 31 assessors obtained a value of 0, 88 with very effective category. So that the E-Tajwid application can be used as a support in learning the science of recitation
Monster Radiative Shocks in the Perturbed Magnetospheres of Neutron Stars
Authors: Beloborodov Andrei M. 
Published: December 2023

Abstract
Magnetospheres of neutron stars can be perturbed by star quakes, interaction in a binary system, or sudden collapse of the star. The perturbations are typically in the kilohertz band and excite magnetohydrodynamic waves. We show that compressive magnetospheric waves steepen into monster shocks, possibly the strongest shocks in the Universe. The shocks are radiative, i.e., the plasma energy is radiated before it crosses the shock. As the kilohertz wave with the radiative shock expands through the magnetosphere, it produces a bright X-ray burst. Then, it launches an approximately adiabatic blast wave, which will expand far from the neutron star. These results suggest a new mechanism for X-ray bursts from magnetars and support the connection of magnetar X-ray activity with fast radio bursts. Similar shocks may occur in magnetized neutron-star binaries before they merge, generating an X-ray precursor of the merger. Powerful radiative shocks are also predicted in the magnetosphere of a neutron star when it collapses into a black hole, producing a bright X-ray transient.
Les premiers enfants eugéniques brésiliens : concours d’eugénisme et vision héréditaire de « l’élite raciale » au Brésil (1928-1929)
Authors: Carvalho Leonardo Dallacqua de , Barbosa Everton Vieira 
Published: December 2023

Dans le cadre des préceptes de l’eugénisme galtonien, des concours eugéniques ont été organisés au Brésil afin d’élire et de diffuser le « profil national idéal ». En s’appuyant sur des revues et des journaux spécialisés, cet article aborde la perspective eugénique déployée dans ces événements, son importance pour le mouvement eugénique brésilien et le rôle de l’Inspection d’Éducation sanitaire au cours de la première moitié du XXe siècle.
Nursing Management of a Patient With Fulminant Myocarditis and Electrical Storm Receiving ECMO: A Case Report
Authors: Wu Xiaoxiao , Wang Xiaoyan , Luo Jinmei , Tian Fang , Bian Jin 
Published: December 2023

Introduction
Fulminant myocarditis is a devastating disease with significant mortality and complications. The care of patients with fulminant myocarditis is rarely reported.

Clinical Findings
A 17-year-old female patient was admitted to the emergency department with dizziness, amaurosis fugax, and chest tightness. Initial assessment revealed elevated levels of troponin T (4.753 ng/mL), troponin I (49.540 ng/mL), creatine kinase (1306 U/L), creatine kinase–MB isoenzymes (75.71 ng/mL), lactate dehydrogenase (509 U/L), and N-terminal pro-B-type natriuretic peptide (6345 pg/mL). The patient had recurrent ventricular tachycardia and failed to maintain a sinus rhythm after multiple electrical cardioversions.

Diagnosis
Echocardiography revealed a left ventricular ejection fraction of 34%. Magnetic resonance imaging results confirmed the diagnosis of myocarditis.

Interventions
The patient received extracorporeal membrane oxygenation for 6 days, intra-aortic balloon pump support for 7 days, and mechanical ventilation for 5 days. Norepinephrine and dopamine were used to keep circulation stable, lidocaine and amiodarone were used to control heart rate, and glucocorticoids and immunoglobulins were used to modulate immunity.

Outcomes
The patient was discharged after 23 days. A month after discharge, echocardiography showed that the ejection fraction was 60%. The patient reported complete resolution of signs and symptoms of fulminant myocarditis at follow-up assessment.

Conclusion
This case report presents the activities of bedside nurses in caring for a patient with fulminant myocarditis and broadens the literature describing nursing interventions for patients with fulminant myocarditis.
Using a Fluid Resuscitation Algorithm to Reduce the Incidence of Abdominal Compartment Syndrome in the Burn Intensive Care Unit
Authors: Peters Jasmine , Won Paul , Herrera Julie , Gillenwater T. Justin , Yenikomshian Haig A. 
Published: December 2023

Background
Patients with large burns must be carefully resuscitated to balance adequate tissue perfusion with the risk of end-organ damage. One devastating complication of overresuscitation is abdominal compartment syndrome. Reducing the volume of fluids given during resuscitation may reduce the incidence of abdominal compartment syndrome and improve outcomes.

Objective
To determine whether decreasing fluid resuscitation volume in a burn center reduced the incidence of abdominal compartment syndrome.

Methods
This retrospective cohort study involved all patients with severe burns (total body surface area ≥20%) who were admitted to a burn intensive care unit over 4 years (n = 166). Primary outcomes were required fluid volume, whether differences in the patient characteristics measured affected outcomes, rate of abdominal compartment syndrome, and incidence of abdominal hypertension. After the first 2 years, the Parkland fluid resuscitation algorithm was modified to decrease the volume goal, and patients were assessed for the incidence of abdominal compartment syndrome and related complications such as kidney failure, abdominal hypertension, and ventilator days.

Results
A total of 16% of patients resuscitated using the Parkland equation experienced abdominal compartment syndrome compared with 10% of patients resuscitated using the modified algorithm, a difference of 6 percentage points (P = .39). Average volume administered was 11.8 L using the Parkland formula and 9.4 L using the modified algorithm (P = .03).

Conclusion
Despite a significant decrease in the amount of fluid administered, no significant difference was found in incidence of abdominal compartment syndrome or urine output. Matched prospective studies are needed to improve resuscitation care for patients with large burns.
Formação inicial de professores de Ciências Naturais:
Authors: Coutinho Maria Beatriz Dias , Gomes Rotta Jeane Cristina 
Published: December 2023

RESUMO

Essa pesquisa teve como objetivo realizar um mapeamento das produções científicas nacionais que abordam os cursos de formação inicial de professores de Ciências Naturais ou da Natureza. A metodologia foi qualitativa do tipo “Estado da Arte”. Foram selecionados 40 artigos, 10 teses e 18 dissertações, analisados com base na Análise de Conteúdo e elencados em quatro categorias: 1- “Análise da formação inicial do professor de CN”; 2- “Interdisciplinaridade e currículos integradores”; 3- “Proposição pedagógicas formativas”; 4- “Espaços e ambientes formadores”. As análises indicaram a complexidade das licenciaturas de Ciências Naturais/Natureza, com base em suas matrizes curriculares, ações e percepções dos diferentes sujeitos que compõe essas licenciaturas. Foi observada a importância de uma formação mais generalista e menos específica em uma única área das Ciências. Em síntese, a formação docente precisa ser integradora e interdisciplinar, composta por diferentes metodologias e estratégias pedagógicas e estruturadas em espaços que promovam diálogos e reflexões.
Pelatihan Cara Deteksi Dini Tumbuh Kembang Anak dan Penanganan Kasus Common Problem Pada Guru Playgroup, TK & Daycare Damian School
Authors: Heliany Kiswantomo  , Evi Ema Victoria Polii  , Vida Handayani  , Marissa Chitra Sulastra  
Published: December 2023

Deteksi dini tumbuh kembang anak diperlukan agar guru dapat membantu anak didik di usia PAUD untuk berkembang dengan lebih optimal. Masalah yang paling signifikan muncul di TK dan Daycare Damian School adalah tantrum dan juga permasalahan bahasa pada peserta didik. Tujuan diselenggarakannya pelatihan ini adalah membekali Guru PAUD dan TK di Damian School khususnya dalam melakukan Deteksi Dini dalam Tumbuh Kembang serta mengatasi permasalahan umum seperti tantrum serta keterlambatan bicara pada peserta didik. Metode yang dipergunakan adalah psikoedukasi melalui pelatihan. Total peserta yang menghadiri kegiatan ini adalah 7 orang guru. Berdasarkan hasil evaluasi, terdapat peningkatan pemahaman peserta akan materi yang telah disampaikan, dengan hasil uji Wilcoxon Sign Rank Test menunjukkan adanya perbedaan signifikan antara pemahaman sebelum dan setelah mengikuti pelatihan, dengan selisih rank bertanda positif (T hitung < T tabel = tolak H0). Artinya pemahaman guru-guru meningkat setelah mengikuti pelatihan ini. Dari hasil evaluasi juga diperoleh gambaran bahwa mayoritas peserta bertekad akan menerapkan materi tersebut dalam kegiatan mereka sehari-hari di lapangan sebagai guru. Dapat disimpulkan bahwa kegiatan pelatihan ini memberikan manfaat bagi guru-guru di TK dan Daycare Damian School.
IMPLEMENTASI MODEL PEMBELAJARAN PROJECT BASED LEARNING (PjBL) TERHADAP PRESTASI BELAJAR SISWA KELAS V SDN BAKALAN WRINGINPITU
Authors: Isnaini Elsah , Untari Rahmania Sri 
Published: December 2023

Rendahnya prestasi belajar siswa diakibatkan karena kurangnya penguasaan materi yang maksimal dalam proses pembelajaran berlangsung. Tujuan penelitian ini adalah untuk mengetahui peningkatan prestasi belajar siswa dengan berbantuan model pembelajaran PjBL pada mata pelajaran Bahasa Indonesia menggunakan soal Prestest dan Posttest. Model pembelajaran PjBL merupakan model yang menggabungkan pembelajaran aktif dalam lingkungan pendidikan berbasis proyek yang mengacu pada dunia nyata siswa. Penelitian ini menggunakan jenis penelitian kuantitatif menggunakan rancangan One Groups Pretest-Posttest Design. Subjek penelitian ini adalah siswa kelas V-B SDN Bakalan Wringinpitu yang berjumalah 19 siswa, yang terdiri atas 12 siswa laki-laki dan 7 siswa perempuan. Teknik analisis data menggunakan uji t sample paired t-test. Hasil penelitian menunjukkan bahwa ada pengaruh model pembelajaran PjBL dengan berbantuan media pembelajaran PPT terhadap prestasi belajar di kelas V sekolah dasar terbukti. Hal ini ditunjukkan hasil uji t dengan nilai sign (2 tailed) sebesar 0.000 < 0.05. Dapat dikatakan bahwa Ho ditolak sehingga Ha diterima dengan arti model pembelajaran PjBL dengan berbantuan media pembelajaran PPT berpengaruh positif terhadap prestasi belajar Mata Pelajaran Bahasa Indonesia dalam Tema 7 kelas V-B SDN Bakalan Wringinpitu tahun ajaran 2022/2023.
PREVALÊNCIA DA DOENÇA PERIODONTAL: EM PACIENTES COM DOENÇA RENAL CRONICA
Authors: Barreto Lídia Fernandes Silva , Oliveira Neto Hélio Simões de , Nogueira Ledson Sampaio 
Published: December 2023

A Periodontite é um tipo de inflamação imunológica sistêmica causada pela infecção complexa de uma variedade de microrganismos na placa subgengival e pelo desequilíbrio do ambiente ecológico microbiano na boca.que afeta os tecidos periodontais, resultando na perda de inserção e destruição do osso alveolar. A doença renal crônica (DRC) é uma condição sistêmica que resulta na perda irreversível da função renal ao longo do tempo. Ela pode ser causada por várias condições, como doenças hereditárias, lesões renais, diabetes e hipertensão não controlada. A doença periodontal e a doença renal crônica podem estar associadas devido a diversos fatores em comum. Este estudo visa como objetivo investigar a relação entre a doença periodontal e a doença renal crônica por meio da revisão de estudos de pesquisa disponíveis na base de dados SciELO. PUBMED, Google Acadêmico. Com base nos resultados obtidos, espera-se que o estudo possa fornecer orientações para profissionais de saúde no desenvolvimento de estratégias de prevenção e tratamento conjuntas para a doença periodontal e a doença renal crônica.
Long-term trends of midlatitude horizontal mesosphere/lower thermosphere winds over four decades
Authors: Jacobi Christoph , Kuchar Ales , Renkwitz Toralf , Jaen Juliana 
Published: December 2023

Abstract. We analyse 43 years of mesosphere/lower thermosphere (MLT) horizontal winds obtained from a joint analysis of low frequency (LF) spaced receiver lower ionospheric drift measurements from late 1978 through 2008 and VHF meteor radar wind observations since summer 2004 at Collm (51.3∘ N, 13.0∘ E). Due to limitations of the earlier LF measurements, we restrict ourselves to the analysis of monthly mean winds near 90 km, which represents the meteor peak height as well as mean LF reflection heights in the MLT. We observe mainly positive trends of the zonal prevailing wind throughout the year, while the meridional winds tend to decrease in magnitude in both summer and winter. Furthermore, there is a change in long-term trends around the late 1990s, which is most clearly visible in summer MLT winds. We compare these measurements with long-term partial reflection radar observations of winds at 81–85 km over Juliusruh (54.6∘ N, 13.4∘ E) since 1990, and find general qualitative agreement of trends except for summer. The latter can be explained by the different altitudes considered, and by the latitude dependence of the summer mesospheric jet.
Anomaly Detection with Decision Trees for AI Assisted Evaluation of Signal Integrity on PCB Transmission Lines
Authors: Ecik Emre , John Werner , Withöft Julian , Götze Jürgen 
Published: December 2023

Abstract. Printed circuit board (PCB) design can be supported to a high degree by adding AI modules to the design system. Predictions from these modules can be made available to the designer in order to speed up circuit design and make it more efficient. Problems regarding signal integrity (SI) can be detected in time by providing hints on component connection or routing. However, the optimization and ML methods used in this context are usually very sophisticated (e.g., Bayesian optimization). Therefore, the design parameters provided by the AI modules must be accepted without further insights (for the experienced as well as the inexperienced designer). In this paper, a decision tree for anomaly detection and SI verification is presented, which by nature of this algorithm provides insights to the decisions made to obtain the proposed design parameters. Using a point-to-point (P2P) network as an example, the prediction accuracy of the AI model is investigated. It is shown that assessing SI effects with a decision tree provides a simple approach to obtain the suggested design. Furthermore, the predictions of the decision tree can be verified against the design rules.