bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAXIMAL STABLE QUOTIENTS OF INVARIANT TYPES IN NIP THEORIES
Authors: KRUPIŃSKI KRZYSZTOF , PORTILLO ADRIÁN 
Published: October 2023

Abstract
For a NIP theory T, a sufficiently saturated model

${\mathfrak C}$

of T, and an invariant (over some small subset of

${\mathfrak C}$

) global type p, we prove that there exists a finest relatively type-definable over a small set of parameters from

${\mathfrak C}$

equivalence relation on the set of realizations of p which has stable quotient. This is a counterpart for equivalence relations of the main result of [2] on the existence of maximal stable quotients of type-definable groups in NIP theories. Our proof adapts the ideas of the proof of this result, working with relatively type-definable subsets of the group of automorphisms of the monster model as defined in [3].
Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study
Authors: Perri Giorgia , Mathers John C. , Martin-Ruiz Carmen , Parker Craig , Walsh Jennifer S. , Eastell Richard , Demircan Kamil , Chillon Thilo S. , Schomburg Lutz , Robinson Louise , Hill Tom R. 
Published: October 2023

AbstractThere is a dearth of data on Se status in very old adults. The aims of this study were to assess Se status and its determinants in 85-year-olds living in the Northeast of England by measuring serum Se and selenoprotein P (SELENOP) concentrations and glutathione peroxidase 3 (GPx3) activity. A secondary aim was to examine the interrelationships between each of the biomarkers. In total, 757 participants (463 women, 293 men) from the Newcastle 85+ Study were included. Biomarker concentrations were compared with selected cut-offs (serum Se: suboptimal 70 µg/l and deficient 45 µg/l; SELENOP: suboptimal 4·5 mg/l and deficient 2·6 mg/l). Determinants were assessed using linear regressions, and interrelationships were assessed using restricted cubic splines. Median (inter-quartile range) concentrations of serum Se, SELENOP and of GPx3 activity were 53·6 (23·6) µg/l, 2·9 (1·9) mg/l and 142·1 (50·7) U/l, respectively. Eighty-two percentage and 83 % of participants had suboptimal serum Se (< 70 µg/l) and SELENOP (< 4·5 mg/l), and 31 % and 40 % of participants had deficient serum Se (< 45 µg/l) and SELENOP (< 2·6 mg/l), respectively. Protein intake was a significant determinant of Se status. Additional determinants of serum Se were sex, waist:hip ratio, self-rated health and disease, while sex, BMI and physical activity were determinants of GPx3 activity. There was a linear association between serum Se and SELENOP, and nonlinear associations between serum Se and GPx3 activity and between SELENOP and GPx3 activity. These findings indicate that most participants had suboptimal Se status to saturate circulating SELENOP.
‘The Jews of Ceylon’: Antisemitism, prejudice, and the Moors of Ceylon
Authors: Wettimuny Shamara 
Published: October 2023

AbstractIn the early twentieth century, economic and religious antagonism between Sinhalese and Moors in Ceylon escalated into widespread, deadly violence. In the immediate aftermath of the 1915 pogrom, which involved the targeting of Moors and their property, the Sinhalese nationalist Anagarika Dharmapala observed that ‘Muhammadans’ had accumulated wealth through ‘Shylockian methods’. Even prior to Dharmapala’s claim, Moors were repeatedly depicted as the ‘Jews of Ceylon’ by both influential Sinhalese actors and colonial state actors. As Ceylon did not have a local Jewish population, this article investigates the use of a rhetorical device that was familiar within the broader networks of empire to ‘other’ a non-Jewish mercantile minority. The article accordingly enquires into how and why antisemitic epithets came to be used in prejudicial speech against Moors. It also explores propaganda portraying Moors in terms of ‘hostile’ Jewish stereotypes and the way in which such stereotypes were deployed in Sinhalese interactions with Moors. By tracing the connections between antisemitism and anti-capitalism, this article aims to contribute to a broader discourse on the positions of Semitic groups in British imperial ideology.
Mental health and service use of parents with and without borderline intellectual functioning
Authors: Rudra Sonya , McManus Sally , Hassiotis Angela , Ali Afia 
Published: October 2023

AbstractBackgroundPeople with borderline intellectual functioning (BIF) encounter greater social adversities than the general population and have an increased prevalence of mental illness. However, little is known about the socio-demographic characteristics and mental health of parents with BIF.MethodsA secondary data analysis of the Adult Psychiatric Morbidity Survey 2014 was conducted. Logistic regression models were fitted to compare differences in socio-demographic, mental health and service-use characteristics between parents and non-parents with and without BIF, and to investigate if the relationship between parent status and mental health outcomes was modified by BIF status, sex, and employment.ResultsData from 6872 participants was analyzed; 69.1% were parents. BIF parents had higher odds of common mental disorder, severe mental illness, post-traumatic stress disorder, self-harm/suicide and were more likely to see their General Practitioner (GP) and to receive mental health treatment than non-BIF parents. BIF parents did not have a higher prevalence of mental health problems than BIF non-parents. Being a parent, after adjusting for BIF status and other confounders, was associated with increased odds of having a common mental disorder, visits to see a GP and treatment for mental health. Female parents had higher odds of treatment for mental health problems.ConclusionsBeing a parent is associated with elevated rates of common mental disorders. There is a higher burden of mental health problems and service use in people with BIF. A greater provision of specialist support services including ascertainment is indicated for this group.
Efficacy and safety of coronary computed tomography angiography in diagnosing coronary lesions in children
Authors: Gould Sharon W. , Harty M. Patricia , Cartoski Mark , Krishnan Vijay , Givler Nicole , Ostrowski John , Tsuda Takeshi 
Published: October 2023

AbstractIntroduction:Identification of paediatric coronary artery abnormalities is challenging. We studied whether coronary artery CT angiography can be performed safely and reliably in children.Materials:Retrospective analysis of consecutive coronary CT angiography scans was performed for image quality and estimated radiation dose. Both factors were assessed for correlation with electrocardiographic-gating technique that was protocoled on a case-by-case basis, radiation exposure parameters, image noise artefact parameters, heart rate, and heart rate variability.Results:Sixty scans were evaluated, of which 96.5% were diagnostic for main left and right coronaries and 91.3% were considered diagnostic for complete coronary arteries. Subjective image quality correlated significantly with lower heart rate, increasing patient age, and higher signal-to-noise ratio. Estimated radiation dose only correlated significantly with choice of electrocardiographic-gating technique with median doses as follows: 2.42 mSv for electrocardiographic-gating triggered high-pitch spiral technique, 5.37 mSv for prospectively triggered axial sequential technique, 3.92 mSv for retrospectively gated technique, and 5.64 mSv for studies which required multiple runs. Two scans were excluded for injection failure and one for protocol outside the study scope. Five non-diagnostic cases were attributed to breathing motion, scanning prior to peak contrast enhancement, or scan acquisition during the incorrect portion of the R-R interval.Conclusions:Diagnostic-quality coronary CT angiography can be performed reliably with a low estimated radiation exposure by tailoring each scan protocol to the patient’s body habitus and heart rate. We propose coronary CT angiography is a safe and effective diagnostic modality for coronary artery abnormalities in children.
Alcohol-Related Presentations to Emergency Departments on Days with Holidays, Social, and Sporting Events: An Integrative Literature Review
Authors: Hagan Stephanie Rae , Crilly Julia , Ranse Jamie 
Published: October 2023

AbstractIntroduction:Events, specifically those where excessive alcohol consumption is common, pose a risk to increase alcohol-related presentations to emergency departments (EDs). Limited evidence exists that synthesizes the impact from events on alcohol-related presentations to EDs.Study Objective:This integrative review aimed to synthesize the literature regarding the impact events have on alcohol-related presentations to EDs.Methods:An integrative literature review methodology was guided by the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) Guidelines for data collection, and Whittemore and Knafl’s framework for data analysis. Information sources used to identify studies were MEDLINE, CINAHL, and EMBASE, last searched May 26, 2021.Results:In total, 23 articles describing 46 events met criteria for inclusion. There was a noted increase in alcohol-related presentations to EDs from 27 events, decrease from eight events, and no change from 25 events. Public holidays, music festivals, and sporting events resulted in the majority of increased alcohol-related presentations to EDs. Few articles focused on ED length-of-stay (LOS), treatment, and disposition.Conclusion:An increase in the consumption of alcohol from holiday, social, and sporting events pose the risk for an influx of presentations to EDs and as a result may negatively impact departmental flow. Further research examining health service outcomes is required that considers the impact of events from a local, national, and global perspective.
The Contribution of Biotic Factors in Explaining the Global Distribution of Inorganic Carbon in Surface Soils
Authors: Zeng Xiao‐Min , Bastida Felipe , Plaza César , Zhou Guiyao , Vera Alfonso , Liu Yu‐Rong , Delgado‐Baquerizo Manuel 
Published: October 2023

AbstractSoil inorganic carbon (SIC) plays a crucial role in regulating global carbon (C) cycling by linking the long‐term geological and short‐term biological C cycles. Soil inorganic carbon stocks are thought to be mainly driven by abiotic factors. However, despite the well‐known influence of vegetation and soil microbes on terrestrial C pools, the relative contribution of biotic and abiotic factors in explaining the global distribution of SIC remains virtually unknown. Here, we conducted a global field survey including information on SIC of 398 composite topsoil samples from 134 locations to investigate the contribution of biotic drivers in explaining the global distribution of SIC in surface soils compared with climate and abiotic factors. Overall, SIC content peaked in arid and temperate ecosystems with warmer and drier conditions, particularly shrublands. We further revealed that although soil properties (e.g., Ca and C/N ratio) explained the highest variance in SIC globally, biotic factors, associated with vegetation and soil microbes, explained a considerable proportion of the global variation in SIC. In particular, plant richness, plant cover, and fungal biomass were significantly and positively associated with SIC, suggesting that biotic control could play an important role in explaining the global distribution of topsoil SIC. We propose that changes in the biotic factors, such as alterations in vegetation and soil microbes resulting from global changes, may have important direct and indirect consequences for global SIC dynamics and terrestrial C‐climate feedback.
Contrasting Storm‐Time Radiation Belt Events With and Without Dropouts—The Importance of CME Shocks
Authors: Nnadih Stanislaus , Blum Lauren , Xiang Zheng , Tu Weichao , Lyu Xingzhi , Usanova Maria E. , Rodger Craig J. 
Published: October 2023

AbstractThis study compares three different geomagnetic storms (designated as storms 1, 2, and 3) observed by NASA's Van Allen Probes within the spacecraft's first 50 days in orbit. These storms were Coronal Mass Ejection (CME)‐driven with minimum DST around −138, −100, and −106 nT, respectively. Storms 1 and 2 occurred following the arrival of fast‐forward shocks, which compressed the magnetopause inward to about 6.5 and 7.5 RE, respectively, as a result of the increase in solar wind dynamic pressure and density. The inward magnetopause motion helped contribute to a rapid depletion of MeV electrons across the entire outer belt. For the third storm, however, there was little or no dropout of MeV electrons in the heart of the outer belt during the storm main phase. This third storm was generated by a CME without an associated shock, and the magnetopause actually moved outward at the start of the storm, suppressing loss of electrons through the outer boundary. The study reveals that under certain solar wind driving conditions radiation belt electron dropouts may not occur, even during large geomagnetic storms (Dst_min < −100 nT).
Tisagenlecleucel vs. historical standard of care in children and young adult patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia
Authors: v. Stackelberg Arend , Jäschke Katja , Jousseaume Etienne , Templin Corinna , Jeratsch Ulli , Kosmides Daniela , Steffen Ingo , Gökbuget Nicola , Peters Christina 
Published: October 2023

AbstractIn the absence of randomized controlled trials comparing tisagenlecleucel vs. standard of care (SOC) in pediatric and young adult patients with relapsed or refractory acute lymphoblastic leukemia (r/r ALL), the objective was to compare the efficacy of tisagenlecleucel with historical controls from multiple disease registries using patient-level adjustment of the historical controls. The analysis is based on patient-level data of three tisagenlecleucel studies (ELIANA, ENSIGN and CCTL019B2001X) vs. three registries in Germany/Austria. Statistical analyses were fully pre-specified and propensity score weighting of the historical controls by fine stratification weights was used to adjust for relevant confounders identified by systematic literature review. Results showed high comparability of cohorts after adjustment with absolute SMD ≤ 0.1 for all pre-specified confounders and favorable outcomes for tisagenlecleucel compared to SOC for all examined endpoints. Hazard ratios for OS(Intention to treat)ITT,adjusted, EFS(Full analysis set)FAS,naïve and RFSFAS,naïve were 0.54 (95% CI: 0.41–0.71, p < 0.001), 0.67 (0.52–0.86, p = 0.001) and 0.77 (0.51–1.18, p = 0.233). The OSITT, adjusted, EFSFAS,naïve and RFSFAS,naive survival probability at 2 years was 59.49% for tisagenlecleucel vs. 36.16% for SOC population, 42.31% vs. 30.23% and 59.60% vs. 54.57%, respectively. Odds ratio for ORRITT,adjusted was 1.99 (1.33–2.97, p < 0.001). Results for OS and ORR were statistically significant after adjustment for confounders and provide evidence supporting a superiority of tisagenlecleucel in r/r ALL given the good comparability of cohorts after adjustment for confounders.
Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice
Authors: Qin Yue , Zhang Xiao-Yong , Liu Yanyan , Ma Zehan , Tao Shuo , Li Ying , Peng Rui , Wang Fei , Wang Jiucun , Feng Jianfeng , Qiu Zilong , Jin Li , Wang Hongyan , Gong Xiaohong 
Published: October 2023

AbstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by core symptoms that consist of social deficits and repetitive behaviors. Unfortunately, no effective medication is available thus far to target the core symptoms of ASD, since the pathogenesis remains largely unknown. To investigate the pathogenesis of the core symptoms in ASD, we constructed Shank1 P1812L-knock-in (KI) mice corresponding to a recurrent ASD-related mutation, SHANK1 P1806L, to achieve construct validity and face validity. Shank1 P1812L-KI heterozygous (HET) mice presented with social deficits and repetitive behaviors without the presence of confounding comorbidities. HET mice also exhibited downregulation of metabotropic glutamate receptor (mGluR1) and associated signals, along with structural abnormalities in the dendritic spines and postsynaptic densities. Combined with findings from Shank1 R882H-KI mice, our study confirms that mGluR1-mediated signaling dysfunction is a pivotal mechanism underlying the core symptoms of ASD. Interestingly, Shank1 P1812L-KI homozygous (HOM) mice manifested behavioral signs of impaired long-term memory rather than autistic-like core traits; thus, their phenotype was markedly different from that of Shank1 P1812L-KI HET mice. Correspondingly, at the molecular level, Shank1 P1812L-KI HOM displayed upregulation of AMPA receptor (GluA2)-related signals. The different patterns of protein changes in HOM and HET mice may explain the differences in behaviors. Our study emphasizes the universality of mGluR1-signaling hypofunction in the pathogenesis of the core symptoms in ASD, providing a potential target for therapeutic drugs. The precise correspondence between genotype and phenotype, as shown in HOM and HET mice, indicates the importance of reproducing disease-related genotypes in mouse models.
Laterally gated ferroelectric field effect transistor (LG-FeFET) using α-In2Se3 for stacked in-memory computing array
Authors: Park Sangyong , Lee Dongyoung , Kang Juncheol , Choi Hojin , Park Jin-Hong 
Published: October 2023

AbstractIn-memory computing is an attractive alternative for handling data-intensive tasks as it employs parallel processing without the need for data transfer. Nevertheless, it necessitates a high-density memory array to effectively manage large data volumes. Here, we present a stacked ferroelectric memory array comprised of laterally gated ferroelectric field-effect transistors (LG-FeFETs). The interlocking effect of the α-In2Se3is utilized to regulate the channel conductance. Our study examined the distinctive characteristics of the LG-FeFET, such as a notably wide memory window, effective ferroelectric switching, long retention time (over 3 × 104 seconds), and high endurance (over 105cycles). This device is also well-suited for implementing vertically stacked structures because decreasing its height can help mitigate the challenges associated with the integration process. We devised a 3D stacked structure using the LG-FeFET and verified its feasibility by performing multiply-accumulate (MAC) operations in a two-tier stacked memory configuration.
Ebf3+ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells
Authors: Nakatani Taichi , Sugiyama Tatsuki , Omatsu Yoshiki , Watanabe Hitomi , Kondoh Gen , Nagasawa Takashi 
Published: October 2023

AbstractLympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors. Here, we show that in mice whose CXC chemokine ligand 12 (CXCL12) is deleted from half HSC niche cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells, HSCs migrate from CXCL12-deficient niches to CXCL12-intact niches. In mice whose CXCL12 is deleted from all Ebf3+/leptin receptor (LepR)+ CAR cells, HSCs are markedly reduced and their ability to generate B cell progenitors is reduced compared with that to generate myeloid progenitors even when transplanted into wild-type mice. Additionally, CXCL12 enables the maintenance of B lineage repopulating ability of HSCs in vitro. These results demonstrate that CAR cell-derived CXCL12 attracts HSCs to CAR cells within bone marrow and plays a critical role in the maintenance of HSCs, especially lymphoid-biased or balanced HSCs. This study suggests an additional mechanism by which cytokines act on HSCs to produce B cells.
Presynaptic gating of monkey proprioceptive signals for proper motor action
Authors: Tomatsu Saeka , Kim GeeHee , Kubota Shinji , Seki Kazuhiko 
Published: October 2023

AbstractOur rich behavioural repertoire is supported by complicated synaptic connectivity in the central nervous system, which must be modulated to prevent behavioural control from being overwhelmed. For this modulation, presynaptic inhibition is an efficient mechanism because it can gate specific synaptic input without interfering with main circuit operations. Previously, we reported the task-dependent presynaptic inhibition of the cutaneous afferent input to the spinal cord in behaving monkeys. Here, we report presynaptic inhibition of the proprioceptive afferent input. We found that the input from shortened muscles is transiently facilitated, whereas that from lengthened muscles is persistently reduced. This presynaptic inhibition could be generated by cortical signals because it started before movement onset, and its size was correlated with the performance of stable motor output. Our findings demonstrate that presynaptic inhibition acts as a dynamic filter of proprioceptive signals, enabling the integration of task-relevant signals into spinal circuits.
The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption
Authors: Ding Weihua , Yang Liuyue , Shi Eleanor , Kim Bowon , Low Sarah , Hu Kun , Gao Lei , Chen Ping , Ding Wei , Borsook David , Luo Andrew , Choi Jee Hyun , Wang Changning , Akeju Oluwaseun , Yang Jun , Ran Chongzhao , Schreiber Kristin L. , Mao Jianren , Chen Qian , Feng Guoping , Shen Shiqian 
Published: October 2023

AbstractChronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heightened pain sensitivity, referred to as CSD-induced hyperalgesia. However, the underlying mechanisms are unclear. The thalamic reticular nucleus (TRN) has unique integrative functions in sensory processing, attention/arousal and sleep spindle generation. We report that the TRN played an important role in CSD-induced hyperalgesia in mice, through its projections to the ventroposterior region of the thalamus. Metabolomics revealed that the level of N-arachidonoyl dopamine (NADA), an endocannabinoid, was decreased in the TRN after CSD. Using a recently developed CB1 receptor (cannabinoid receptor 1) activity sensor with spatiotemporal resolution, CB1 receptor activity in the TRN was found to be decreased after CSD. Moreover, CSD-induced hyperalgesia was attenuated by local NADA administration to the TRN. Taken together, these results suggest that TRN NADA signaling is critical for CSD-induced hyperalgesia.
Three-dimensional ultrasound matrix imaging
Authors: Bureau Flavien , Robin Justine , Le Ber Arthur , Lambert William , Fink Mathias , Aubry Alexandre 
Published: October 2023

AbstractMatrix imaging paves the way towards a next revolution in wave physics. Based on the response matrix recorded between a set of sensors, it enables an optimized compensation of aberration phenomena and multiple scattering events that usually drastically hinder the focusing process in heterogeneous media. Although it gave rise to spectacular results in optical microscopy or seismic imaging, the success of matrix imaging has been so far relatively limited with ultrasonic waves because wave control is generally only performed with a linear array of transducers. In this paper, we extend ultrasound matrix imaging to a 3D geometry. Switching from a 1D to a 2D probe enables a much sharper estimation of the transmission matrix that links each transducer and each medium voxel. Here, we first present an experimental proof of concept on a tissue-mimicking phantom through ex-vivo tissues and then, show the potential of 3D matrix imaging for transcranial applications.