bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are business growth and entrepreneurial motivations competing with environmental intention among nascent entrepreneurs?
Authors: Tounés Azzedine , Tornikoski Erno 
Published: February 2024

Purpose
The purpose of this study is to investigate whether business growth intention (BGI) and entrepreneurial motivations enhance the explanatory power of the theory of planned behavior (TPB) to predict environmental intention (EI) among nascent entrepreneurs.

Design/methodology/approach
In the context of nascent entrepreneurship, the authors collected data from 193 nascent entrepreneurs in France. To test the hypotheses, stepwise multiple regression was performed.

Findings
The results show that BGI has a positive influence on EI. This indicates that it is possible for French nascent entrepreneurs to plan the simultaneous pursuit of business growth and environmental goals. However, entrepreneurial motivations have a mixed effect on EI. If necessity motivations negatively influence EI, opportunity motivations have no significant effect on the latter.

Originality/value
To the best of the authors’ knowledge, this research is among the first to extend the TBP model with additional factors, namely, BGI and necessity/opportunity motivations, to study EI. Moreover, the extended TBP model is validated in the under-research context of nascent entrepreneurship.
Academic community’s use of university digital library and their searching behaviour
Authors: Rafique Azra , Ameen Kanwal , Arshad Alia 
Published: February 2024

Purpose
This study aims to explore the evidence-based usage patterns of higher education commission (HEC) subscribed e-journal databases in the university digital library used by the scholarly community and the academics’ online searching behaviour at a higher education institution in Pakistan.

Design/methodology/approach
The study used an explanatory sequential mixed methods approach. Raw transaction log data were collected for quantitative analysis, and the interview technique was used for qualitative data collection and thematic analysis.

Findings
Log analysis revealed that HEC subscribed databases were used significantly, and among those, scholarly databases covering various subjects were more frequently used than subject-specific society-based databases. Furthermore, the users frequently accessed the needed e-journal articles through search engines like Google and Google Scholar, considering them sources of free material instead of the HEC subscribed databases.

Practical implications
It provides practical implications for examining the evidence-based use patterns of e-journal databases. It suggests the need for improving the access management of HEC databases, keeping in view the usage statistics and the demands of the scholars. The study may also help create market venues for the publishers of scholarly databases by offering attractive and economical packages for researchers of various disciplines in developing and underdeveloped countries. The study results also guide the information professionals to arrange orientation and information literacy programs to improve the searching behaviour of their less frequent users and enhance the utilization of these subscribed databases.

Originality/value
The study is part of a PhD project and, to the best of the authors’ knowledge, is the first such work in the context of a developing country like Pakistan.
Smart hotels but not necessarily smart decisions: the smartness paradox
Authors: Wong IpKin Anthony , Xiao Ya , Lin Zhiwei (CJ) , Sun Danni , Huang Jingwen (Daisy) , Liu Matthew 
Published: February 2024

Purpose
This paper aims to answer questions pertinent to whether or not services provided by smart hotels are really what customers are looking for, as well as to ascertain what are some unintended experiences guests may encounter. In essence, to the best of the authors’ knowledge, this research is the first in the field to acknowledge the paradox of smart service.

Design/methodology/approach
This inquiry adopts a qualitative approach with data-driven from online customer reviews and semistructured interviews. Thematic analysis was undertaken to interpret review comments.

Findings
Results point to a new phenomenon, which is coined as the smartness paradox. In particular, customers on one hand enjoy an array of smart-infused experiences that jointly offer patrons a sense of a futuristic lifestyle. On the other hand, smart devices superimpose a number of hindrances that bring guests dismay and annoyance.

Research limitations/implications
This investigation brings smart service failure to the fore to highlight several key failure themes that could jeopardize the entire operation with debased customers’ satisfaction and loyalty inclination.

Originality/value
The smartness-paradox framework used in the present inquiry entails both approach and avoidance consequences customers enact depending on their smart experiences.
The hidden costs of resistance: Contrasting the energetics of successfully and unsuccessfully fighting infection
Authors: Hall Matthew D. , Phillips Ben L. , White Craig R. , Marshall Dustin J. 
Published: February 2024

Abstract

Exposure to a pathogen is predicted to lead to increased energy use as hosts attempt to activate a costly immune system and repair damaged tissue. To meet this demand, metabolic rates, which capture the rate at which a host can use, transform and expend energy, are expected to increase. Yet for many host–pathogen systems, metabolic rates after encountering a pathogen are just as likely to decrease as increase, suggesting that increased energy expenditure may not always be best for fighting infection.

Diverging metabolic trajectories have been previously attributed to the different pathways that specific pathogen classes, such as bacteria or viruses, induce in a host. Here, we test how the magnitude and direction of metabolic change following pathogen exposure might also depend on whether a host has cleared infection or is instead fighting to reduce pathogen burden, as well as interactions between host and pathogen genotypes of a single host–pathogen system.

Using a model system, Daphnia magna and its bacterial pathogen, we quantified changes in mass‐independent metabolic rates over a 30‐day period for multiple host and pathogen genotypes. We found that the metabolic trajectory of an exposed host diverged quickly during the infection process. For hosts that were exposed to a pathogen and resisted infection, their mass‐independent metabolic rates remained suppressed long after exposure, leading to a sustained reduction in total energy use compared to unexposed animals. The reverse was true for hosts in which the pathogen was able to establish an infection.

Underlying these changes were differences in the energetic burden that each pathogen genotype imposed on its host, as well as changes in the way host genotype and the outcome of infection shaped underlying scaling relationships between host body mass and metabolic rates. Our results demonstrate how variation in an organism's metabolic rate and overall energy use can arise from within a single host–pathogen encounter and depend on the likelihood of pathogen clearance, as well as the within‐species genetic variability of both hosts and pathogens.

Read the free Plain Language Summary for this article on the Journal blog.
Animal‐mediated seed dispersal and the demo‐genetic configuration across plant colonization gradients
Authors: Isla Jorge , Jácome‐Flores Miguel , Rigueiro Cristina , Arroyo Juan Miguel , Jordano Pedro , García Cristina 
Published: February 2024

Abstract

Ecologists have long recognized that seed dispersal mutualisms trigger natural regeneration and range expansion of animal‐dispersed trees. Yet we lack empirical studies addressing whether frugivore activity influences founder effects, which reduce genetic diversity at the colonization front of expanding populations.

Here, we evaluate the contribution, from both demographic and genetic perspectives, of animal frugivores dispersing seeds across an expansion gradient. We used DNA barcoding for frugivores identification and highly polymorphic genetic markers (SSRs) for maternal analysis of juniper seeds to investigate how (1) stand maturity, (2) microhabitat types and (3) foraging patterns shape the distribution of the maternal progenies along this gradient.

We expect both reduced seed rain density and low numbers of source trees contributing to the seed rain at the colonization front, with limited availability of local fruiting trees. We also anticipated that large‐sized frugivore species would promote maternally rich seed rain due to their ability to mix seed progenies during digestive processing and move further distances across the landscape.

Contrary to our expectations, we found that all identified frugivores produced dense and genetically diverse seed rains across the expansion gradient, even at the colonization front, characterized by scarce fruiting trees.

Synthesis: Our findings shed light on the fundamental and applied implications of plant–frugivore interactions in shaping highly diverse second‐growth forests. These results emphasize the necessity of preserving plant–animal mutualistic interactions to ensure the persistence and expansion of natural tree populations, particularly in formerly fragmented landscapes
A Shout‐out for the Value of Management Education Research: ‘Pedagogy is not a Dirty Word’
Authors: Mason Katy , Anderson Lisa , Black Kate , Roberts Ashley 
Published: February 2024

AbstractManagement Learning Education (MLE) research and curriculum and pedagogy innovation are urgently needed to lead our world out of crisis. If we are to take responsibility for educating future leaders of business, third‐ and public‐sector organizations with the skills, competences and knowledge to deliver sustainable futures for the planet and people, then pedagogy cannot be a dirty word. In this essay, we consider the state we're in by looking at the juncture of [climate] crisis, with the lack of investment in MLE research and innovation, and management education market misfires – which together, constitute MLE as undervalued, underfunded and underdeveloped. We discuss advances in MLE theory to reveal a missing middle of understanding, namely between meta theories of pedagogic philosophies and values and infra theories of programme, course and project insights, as we work toward developing ‘responsible’ and ‘civic’ management schools. Drawing on our own experience as researchers, educators and pedagogy developers, and as past and present vice‐chairs of the Management Knowledge and Education initiative at the British Academy of Management, we call for investments in supporting infrastructures to accelerate MLE and curriculum and pedagogy innovation, implicating learned societies, governments and higher education institutions.
Preparation and characterization of nisin‐loaded chitosan nanoparticles functionalized with DNase I for the removal of Listeria monocytogenes biofilms
Authors: Hu Xin , Du Xueying , Li Mingwei , Sun Jing , Li Xiangfei , Pang Xinyi , Lu Yingjian 
Published: February 2024

AbstractListeria monocytogenes biofilms represent a continuous source of contamination, leading to serious food safety concerns and economic losses. This study aims to develop novel nisin‐loaded chitosan nanoparticles (CSNPs) functionalized with DNase I and evaluate its antibiofilm activity against L. monocytogenes on food contact surfaces. Nisin‐loaded CSNPs (CS‐N) were first prepared by ionic cross‐linking, and DNase I was covalently grafted on the surface (DNase‐CS‐N). The NPs were subsequently characterized by Zetasizer Nano, transmission electron microscopy, Fourier transform infrared (FT‐IR), and X‐ray diffraction (XRD). The antibiofilm activity of NPs was evaluated against L. monocytogenes on polyurethane (PU). The DNase‐CS‐N was fabricated and characterized with quality attributes (particle size—427.0 ± 15.1 nm, polydispersity [PDI]—0.114 ± 0.034, zeta potential—+52.5 ± 0.2 mV, encapsulation efficiency—46.5% ± 3.6%, DNase conjugate rate—70.4% ± 0.2). FT‐IR and XRD verified the loading of nisin and binding of DNase I with chitosan. The DNase‐CS‐N caused a 3 log colony‐forming unit (CFU)/cm2 reduction of L. monocytogenes biofilm cells, significantly higher than those in CSNPs (1.4 log), CS‐N (1.8 log), and CS‐N in combination with DNase I (2.2 log) treatment groups. In conclusion, nisin‐loaded CSNPs functionalized with DNase I were successfully prepared and characterized with smooth surface and nearly spherical shape, high surface positive charge, and good stability, which is effective to eradicate L. monocytogenes biofilm cells on food contact surfaces, exhibiting great potential as antibiofilm agents in food industry.Practical ApplicationListeria monocytogenes biofilms are a common safety hazard in food processing. In this study, novel nanoparticles were successfully constructed and are expected to be a promising antibiofilm agent in the food industry.
Transcriptomic analysis reveals ozone treatment delays kiwifruit postharvest softening by modulating cell wall metabolism
Authors: Wang Yan , Niu Yaoxing , Ye Lixia , Shi Yubing , Luo Anwei 
Published: February 2024

AbstractKiwifruit ripening and senescence after harvesting are closely related to its economic value. Transcriptome analysis and biochemical parameters were used to investigate the differences in gene expression levels and the potential regulation of cell wall metabolism in kiwifruit treated with ozone, thereby regulating fruit softening and prolonging postharvest life. Compared to the control group, the activities of the cell wall modification enzyme were lower under ozone treatment, the content of polysaccharide in the cell wall of primary pectin and cellulose was higher, and the content of soluble pectin was lower. Meanwhile, ozone treatment delayed the degradation of the cell wall mesosphere during storage. A total of 20 pectinesterase (PE)‐related genes were identified by sequencing analysis. The data analysis and quantitative polymerase chain reaction results confirmed that cell wall modifying enzyme genes played an important role in softening and senescence after harvesting, which may reduce or induce the expression of certain genes affecting cell wall metabolism. Ozone treatment not only regulates active genes such as xyloglucan endo glycosyltransferase/hydrolase, cellulose synthase, polygalacturonase, and PE to maintain the quality of fruit after harvest but also acts synergically with cell wall modifying enzymes to inhibit the degradation of cell wall, resulting in changes in the ultrastructure of cell wall, thereby reducing the hardness of kiwifruit. In addition, according to the results of cis‐acting elements, cell wall degradation is also related to downstream hormone signaling, especially PE‐related genes. These results provide a theoretical basis for studying the mechanism of firmness and cell wall metabolism difference of kiwifruit and also lay a good foundation for further research.
Calcium absorption by Alaska pollock surimi protein hydrolysate promotes osteoblast differentiation
Authors: Eom TaeKil , Nam Taek‐Jeong 
Published: February 2024

AbstractThe calcium‐binding capacity and osteoblast proliferation and differentiation were studied in Alaska pollock surimi hydrolysate (APSH) using a system that mimics the gastrointestinal digestive system. Evaluation of the calcium absorption–promoting ability of APSH revealed that the best calcium‐binding ability was achieved after hydrolysis with a combination of pepsin, α‐chymotrypsin, and trypsin, and separation into <3 kDa (APSH‐I), 3–5 kDa (APSH‐II), 5–10 kDa (APSH‐III), and <10 kDa (APSH‐IV) fractions. Scanning electron microscopy with energy‐dispersive X‐ray spectroscopy analysis confirmed that the hydrolysate and calcium ions formed a complex. Comparison of the calcium absorption capacity using Caco‐2 cells showed that calcium absorption was promoted by these hydrolysates. Measurement of the osteoblast activation revealed higher alkaline phosphatase activity, collagen synthesis, and mineralization effect for the low‐molecular‐weight hydrolysate (LMH) than for the other hydrolysates. In addition, LMH promoted the expression of osteocalcin, osteopontin, and bone morphogenetic protein‐2 and ‐4, which are hormones related to bone formation. Expression of the Runx2 transcription factor, which regulates the expression of these hormones, also increased. These results suggest that Alaska pollock surimi protein hydrolysates prepared using a system that mimics gastrointestinal hydrolysis may result in better osteoblast proliferation and bone health than those prepared using other proteases.
Updated epithelial barrier dysfunction in chronic rhinosinusitis: Targeting pathophysiology and treatment response of tight junctions
Authors: Huang Zhi‐Qun , Liu Jing , Sun Li‐Ying , Ong Hsiao Hui , Ye Jing , Xu Yu , Wang De‐Yun 
Published: February 2024

AbstractTight junction (TJ) proteins establish a physical barrier between epithelial cells, playing a crucial role in maintaining tissue homeostasis by safeguarding host tissues against pathogens, allergens, antigens, irritants, etc. Recently, an increasing number of studies have demonstrated that abnormal expression of TJs plays an essential role in the development and progression of inflammatory airway diseases, including chronic obstructive pulmonary disease, asthma, allergic rhinitis, and chronic rhinosinusitis (CRS) with or without nasal polyps. Among them, CRS with nasal polyps is a prevalent chronic inflammatory disease that affects the nasal cavity and paranasal sinuses, leading to a poor prognosis and significantly impacting patients' quality of life. Its pathogenesis primarily involves dysfunction of the nasal epithelial barrier, impaired mucociliary clearance, disordered immune response, and excessive tissue remodeling. Numerous studies have elucidated the pivotal role of TJs in both the pathogenesis and response to traditional therapies in CRS. We therefore to review and discuss potential factors contributing to impair and repair of TJs in the nasal epithelium based on their structure, function, and formation process.
Differential expression of reproduction‐related genes in shrimps from East Pacific fisheries
Authors: Jimenez‐Gutierrez Laura R. 
Published: February 2024

AbstractShrimp fisheries and culture are important food sources worldwide. Central East Pacific fisheries are mainly supported by four species: Penaeus brevirostris, P. californiensis, P. stylirostris and P. vannamei. However, the same shrimp fishery practices, management strategies and closures are applied to these four species despite their differences in life history and reproductive periods. Most molecular studies have focused on the cultured species P. vannamei, while knowledge for the rest of the species is scarce. Therefore, this study sought to examine the transcriptomes of these four shrimp species from the Mexican Pacific at different maturity stages. A total of 165 unigenes were found to be reproduction‐related in the four shrimp species. The genes with the highest overall expression levels were associated with ribosomes, transcription and methyltransferase pathways. Moreover, the reproduction‐related genes with the highest expression values were polehole protein and ovarian peritrophin. The major expression similarities were primarily among pre‐vitellogenic and vitellogenic females within each species, and secondly among the species P. brevirostris and P. californiensis and the species P. vannamei and P. stylirostris. Although these four species might share a geographical location or niche, the expression of reproduction related‐genes at different gonadal maturity stages exhibited species‐specific variations.
Outcomes in patients with multiple myeloma receiving salvage treatment after BCMA‐specific CAR‐T therapy: A retrospective analysis of LEGEND‐2
Authors: Liu Rui , Yang Rui , Xu Xuezhu , Zhao Wanhong , Wang Fangxia , Zhang Wanggang , Lei Bo , Yang Ruoyu , Wang Yiwen , He Aili , Wang Jianli 
Published: February 2024

SummaryChimeric antigen receptor T‐cell (CAR‐T) therapy targeting B‐cell maturation antigen (BCMA) has shown profound efficacy and manageable toxicity in patients with relapsed/refractory multiple myeloma (RRMM). However, determining the best course of treatment for post‐CAR‐T therapy relapse remains a significant challenge. We conducted a retrospective analysis of patients from the phase I LEGEND‐2 study (NCT03090659) enrolled at the Xi'an site, analysing the first salvage line of therapy and outcomes in patients with RRMM who progressed after receiving LCAR‐B38M CAR‐T therapy. Of 45 eligible patients, 34 (76%) had progressive disease (PD). Overall response rate (ORR) to salvage treatment was 50.0%. Median progression‐free survival (PFS) after starting salvage treatment was 16.3 months. Median PFS of patients receiving proteasome inhibitor (PI)‐based combination therapy was longer (28.2 months) than that of patients receiving a second BCMA CAR‐T (including LCAR‐B38M; 3.9 months, p = 0.0022) or chemotherapy (1.67 months, p = 0.0001). All patients with extramedullary disease at baseline (n = 11) progressed after CAR‐T therapy; ORR to salvage therapy was 25.0% and median PFS was 9.7 months. In conclusion, salvage therapy in patients with PD after receiving LCAR‐B38M CAR‐T cells produced moderate efficacy, with better outcomes for PI‐based salvage regimens.
Voltage tunes mGlu5 receptor function, impacting synaptic transmission
Authors: Boutonnet Marin , Carpena Camille , Bouquier Nathalie , Chastagnier Yan , Font‐Ingles Joan , Moutin Enora , Tricoire Ludovic , Chemin Jean , Perroy Julie 
Published: February 2024

Background and PurposeVoltage sensitivity is a common feature of many membrane proteins, including some G‐protein coupled receptors (GPCRs). However, the functional consequences of voltage sensitivity in GPCRs are not well understood.Experimental approachIn this study, we investigated the voltage sensitivity of the post‐synaptic metabotropic glutamate receptor mGlu5 and its impact on synaptic transmission. Using biosensors and electrophysiological recordings in non‐excitable HEK293T cells or neurons.Key ResultsWe found that mGlu5 receptor function is optimal at resting membrane potentials. We observed that membrane depolarization significantly reduced mGlu5 receptor activation, Gq‐PLC/PKC stimulation, Ca2+ release and mGlu5 receptor‐gated currents through transient receptor potential canonical, TRPC6, channels or glutamate ionotropic NMDA receptors. Notably, we report a previously unknown activity of the NMDA receptor at the resting potential of neurons, enabled by mGlu5.Conclusions and ImplicationsOur findings suggest that mGlu5 receptor activity is directly regulated by membrane voltage which may have a significant impact on synaptic processes and pathophysiological functions.