bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropathic diabetic foot ulcers in the elderly: clinical outcomes and healing
Authors: Lamont Peter , Meally Helena , Drydon Emma , Russell David A , Santhakumar Anjali 
Published: December 2023

There is little evidence on healing outcomes of neuropathic foot ulcers in elderly patients.
Aims: To determine the healing rates of neuropathic diabetic foot ulcers at 12 and 24 weeks achieved by standard care provided at an established multidisciplinary diabetes foot clinic in patients aged 65 years and above. Data on the incidence of falls and hypoglycaemia were also collected due to their perceived clinical risk in the group studied.
Methods: This was a retrospective observational study looking at clinical outcomes of neuropathic foot ulcers. Patients aged 65 years or more presenting with a non-infected neuropathic ulcer at the time of their initial review were identified and classified into two groups: Group E patients were aged above 80 years and Group Y patients 65-80 years.
Results: A total of 97 patients, presenting with 106 ulcer episodes, were identified. Mean HbA1c was 60 mmol/mol in Group Y and 55 mmol/mol in Group E. Healing rates of all ulcers at 12 and 24 weeks in the elderly group lagged behind rates in the younger group (67.6% at 12 weeks and 73% at 24 weeks in Group E vs. 78.2% at both intervals in Group Y).
The elderly group had more falls, 11% vs. 2% in Group Y. In all, 50% of the falls in Group E were attributed to their prescribed pressure relief (off-loading) devices.
Conclusions: With standard foot care given in a multi- disciplinary foot service, neuropathic diabetic foot ulcers can heal in the elderly despite their age-related skin changes.
The rate of healing of neuropathic ulcers noted in our study provides a benchmark for healing outcomes and enables comparison with other age groups and centres. Our study identifies a risk of falls associated with off-loading devices and highlights the need for structured falls risk and mobility assessments in this group.
Çocuk Hastalarda İntraoperatif Analjezinin Genel Anestezi Altında Yapılmış Olan Diş Tedavilerinden Sonraki Ağrı Algısı Üzerine Etkisinin Değerlendirilmesi
Authors: ÖNTEKİN Elif , TOSUN Gül , ARUN Funda 
Published: December 2023

ÖZ
Amaç: Genel anestezi (GA) altında diş tedavisi sırasında intraoperatif verilen parasetamolün postoperatif ağrı algısı üzerine etkisini değerlendirmeyi amaçladık.
Gereç ve Yöntem: Etik kurul onayı alındıktan sonra Selçuk Üniversitesi Diş Hekimliği Fakültesi Genel Anestezi ve Sedasyon Kliniği’nde 2020-2021 yıllarında günübirlik anestezi ile tedavileri yapılmış olan çocuk hastaların kayıtları kullanılmıştır. Hastaların anestezi dosyalarından demografik verileri, anestezi süreleri, dental tedavi süreleri, yapılan ağrılı işlemler, lokal anestezik kullanımı, intraoperatif parasetamol kullanımı, postoperatif 1. ve 2. saat kaydedilmiş ağrı skorları, servise çıkış süreleri, derlenme odasında ek ağrı kesici yapılıp yapılmadığı ile ilgili veriler taranmıştır. Çalışmanın istatistiksel analizleri için “Microsoft Excel 2016” ve “IBM SPSS Statistics 26” paket programları kullanılmıştır. Temel demografik tanımlayıcı istatistikler için sıklık ve oransal dağılım verilmiş ve birbirleriyle çaprazlamaları incelenmiştir.
Bulgular: Çalışmaya dahil edilen 246 çocuk hastanın 136’sı erkek ve 110’u kız; en küçüğü 3 ve en büyüğü 15 yaşında idi. Bu hastaların anestezi kayıtlarının istatiksel değerlendirilmesiyle elde ettiğimiz sonuçlara göre; intraoperatif parasetamol uygulanmış grupla uygulanmamış grup arasında; postoperatif 1. saat ağrı skorlarında, taburculuk sürelerinde, postoperatif dönemde ek analjezik ihtiyaçlarında istatistiksel olarak anlamlı bir fark gözlemlenirken, postoperatif 2. saat ağrı skorlarında, vücut ağırlıklarında ve cinsiyet dağılımında anlamlı bir fark bulunmamıştır.
Sonuç: İntraoperatif olarak uygulanan parasetamolün çocuk hastalara daha konforlu bir postoperatif süreç yaşattığını düşünmekteyiz.
Anahtar Kelimeler: dental tedavi, genel anestezi, parasetamol
Komposisi Pakan Lutung Jawa (Trachypithecus auratus E. Geoffroy Saint-Hilaire, 1812) di Kebun Binatang Gembira Loka, Yogyakarta
Authors: Purba Laurentia Henrieta Permita Sari , Apitalau Jeremia Frandy , Prihatmo Guruh 
Published: December 2023

AbstrakKemampuan untuk menemukan, memanen, dan memproses makanan sangat penting untuk kelangsungan hidup hewan. Pemilihan jenis pakan pada hewan sangat bergantung pada ketersediaan makanan di habitatnya dan adaptasi morfologi khususnya organ pencernaan hewan. Trachypithecus auratus adalah primata endemik Pulau Jawa, Bali, dan Lombok yang terdaftar sebagai satwa rentan oleh IUCN (vulnerable) dan CITES (Appendix II). Upaya konservasi Lutung Jawa antara lain dengan sistem ex-situ di Kebun Binatang Gembira Loka, Yogyakarta. Pemberian jenis pakan yang disesuaikan dengan pakan alami Lutung Jawa menjadi salah satu upaya untuk mencapai kesejahteraan hewan konservasi. Oleh karena itu, penelitian ini dilakukan untuk mengamati komposisi pakan populasi Lutung Jawa di Kebun Binatang Gembira Loka dengan total waktu 480 jam melalui metode scan sampling. Komposisi pakan Lutung Jawa yang diberikan oleh Kebun Binatang Gembira Loka terdiri adalah daun (7%), buah dan sayur (92%), dan suplemen (4%), Jenis pakan yang paling banyak dikonsumsi oleh Lutung Jawa di Kebun Binatang Gembira Loka adalah buah dan sayur. Hal ini menunjukkan perilaku makan Lutung Jawa di Kebun Binatang Gembira Loka berbeda dengan perilaku makan alaminya, yaitu sebagai pemakan daun (folivor) sehingga diperlukan penyesuaian komposisi pakan lutung Jawa di Kebun Binatang Gembira Loka, Yogyakarta.AbstractThe ability to find, harvest, and process food is critical to animal survival. The choice of food type for animals is very dependent on the availability of food in their habitat and morphological adaptations, especially the animal's digestive organs. Trachypithecus auratus is a primate endemic to the islands of Java, Bali and Lombok which is listed as vulnerable by IUCN (vulnerable) and CITES (Appendix II). Javanese langur conservation efforts include an ex-situ system at the Gembira Loka Zoo, Yogyakarta. Providing types of feed that are compatible with the natural diet of Javan langurs is one of the efforts to achieve the welfare of conservation animals. Therefore, this research was conducted to observe the food composition of the Javan langur population at Gembira Loka Zoo for a total of 480 hours using the scan sampling method. The composition of the Javanese langur feed provided by the Gembira Loka Zoo consists of leaves (7%), fruit and vegetables (92%), and supplements (4%), where fruit and vegetable feed has the highest percentage of consumption by each individual. Apart from that, the group of food consumed was compared with wild populations from the results of research that has been carried out, where Javan langurs at the Gembira Loka Zoo consume more fruit and vegetables. This shows that the eating behavior of Javan langurs at Gembira Loka Zoo is different from their natural eating behavior, namely leaf eating (folivor), so it is necessary to adjust the food composition of Javan langurs at Gembira Loka Zoo, Yogyakarta.
Efektivitas Pertumbuhan dan Hasil Tanam Beberapa Kultivar Kedelai (Glycine max (L) Merr.) dengan Pemberian Polietilena Glikol (PEG) Untuk Simulasi Cekaman Kekeringan
Authors: Anindya Winda , Palupi Dian , Budisantoso Iman 
Published: December 2023

AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh interaksi varietas kedelai dengan konsentrasi Polietilen glikol (PEG) yang diberikan terhadap pertumbuhan serta hasil tanam dan menentukan varietas kedelai yang toleran terhadap cekaman kekeringan. Penelitian dilakukan dengan menggunakan metode Rancangan Acak Kelompok (RAK) faktorial yang terdiri dari 2 faktor. Faktor pertama adalah varietas kedelai, yaitu Gepak Kuning, Argomulyo, dan Anjasmoro, sedangkan faktor kedua adalah konsentrasi PEG yang diberikan, yaitu 0% (kontrol), 5%, 10%, dan 15%. Pengamatan dilakukan secara destruktif pada hari ke-20, 40, 60 setelah tanam dan saat panen dengan ulangan dilakukan sebanyak tiga kali, sehingga terdapat 36 unit percobaan. Parameter yang diamati meliputi bobot basah, bobot kering, luas daun, laju asimilasi bersih, dan bobot biji pertanaman. Data yang diperoleh dianalisis menggunakan ANOVA pada taraf 5% dan dilakukan uji Honestly Significance Different. Hasil penelitian menunjukkan bahwa tidak ada interaksi antara varietas kedelai dan konsentrasi PEG yang diberikan. Pada variabel yang diamati varietas Argomulyo memiliki respon fisiologi lebih baik dengan nilai rata-rata bobot basah, bobot kering, luas daun, laju asimilasi bersih, dan bobot biji pertanaman tertinggi dibandingkan Anjasmoro dan Gepak Kuning pada seluruh konsentrasi PEG. AbstractThe first aim of this research was to determine the effect of the interaction of soybean varieties with the concentration of Polyethylene glycol (PEG) given on plant growth and yield, and secondly to determine soybean varieties that are tolerant to drought stress. The research was conducted using the factorial Completely Randomized Design (RAK) method consisting of 2 factors. The first factor is the soybean variety, namely Gepak yellow, Argomulyo, and Anjasmoro, while the second factor is the PEG concentration given, namely 0% (control), 5%, 10%, and 15%. Observations were carried out destructively on days 20, 40, 60 after planting and at harvest with repetitions carried out three times, so there were 36 experimental units. The parameters observed included wet weight, dry weight, leaf area, net assimilation rate, and seed weight planted. The data obtained were analyzed using ANOVA at the 5% level and an Honestly Significance Different test was carried out. The results showed that there was no interaction between soybean varieties and the PEG concentration provided. In the variables observed, the Argomulyo variety had a better physiological response with the highest average value of wet weight, dry weight, leaf area, net assimilation rate, and seed weight compared to Anjasmoro and Gepak Kuning at all PEG concentrations.
Rail transport electric drive with intelligent control system
Authors: Kyrylenko Yaroslav , Senchenko Serhii , Vorobiov Bohdan , Khan Liu , Likhno Yaroslav 
Published: December 2023

Purpose. The study of the conditions for the occurrence of frictional self-oscillations, the synthesis of a neuroregulator eliminating self-oscillation, the development of a system for automatic control of the of railway transport speed depending on the curvature of the track on the basis of computer vision technology.
Methodology. Mathematical analysis and modeling.
Findings. The paper presents the results of the development and research of an intelligent control system for the electric drive of a DS3 mainline electric locomotive. The developed systems have a single easily implemented motor speed feedback, which does not create difficulties in physical implementation. It is noted that a common feature of the electric drive of rail transport is a nonlinear load characteristic. It is shown that, under certain combinations of parameters, frictional self-oscillations are possible in the traction electric drive. Effective elimination of frictional self-oscillations is done by synthesizing the system with a neuroregulator. The neural network has three input neurons that receive a vector of input signals in the form of a voltage signal, a signal of the motor speed value of the current and previous energy speed values. The number of neurons in the hidden layer of the system is 20 and there is one output neuron.The control actions for the frequency converter are formed on the output neuron. Neural networks of this type are designated NN3-20-1. The genetic algorithm method is used for all optimization of neural network parameters. The simulation model of the electric drive of rail transport has the integration of a computer vision unit. Increasing the level of automation and safety of rail vehicles is possible on the basis of computer vision. A feature of this structure is the presence of an NN neural regulator in it. NN ensures the specified quality of the transient process over the entire load range and when the operating point is located on a falling section. A system for automatic control of the speed of rail vehicles depending on the curvature of the track has been developed to increase the level of automation and traffic safety. Modeling of the system showed its efficiency, which is manifested in a decrease in the speed of rail vehicles when moving along a section of track with curvature.
Originality. Effective elimination of frictional self-oscillations due to the use of a neuroregulator.
Practical value. A system for automatically adjusting the speed of rail transport depending on the curvature of the track has been developed to increase the level of automation and traffic safety.
Multicomponent reaction for the synthesis of novel fluorinated 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitriles
Authors: Ha Thanh Nguyen , Phuong Hoang Thi , Giang Le Nhat Thuy , Quynh Giang Nguyen Thi , Tuan Anh Nguyen , Tuyet Anh Dang Thi , Tuyen Nguyen Van 
Published: December 2023

Chromene is a significant class of heterocyclic compounds prossessing a simple structure as well as important biological activities. Many studies have been done to find new approaches for the preparation of chromene derivatives. Notably, the introduction of fluorine into heterocyclic molecules resulted in a significant improvement of their biological activities. In this study, a simple, straightforward, and highly efficient microwave-assisted three-component synthesis of novel 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitrile derivatives bearing fluorine atoms has been developed using 1,4-diazabicyclo[2.2.2]octane (DABCO) as an eco-friendly catalyst, and acetonitrile as a solvent. Starting from 2-hydroxy-1,4-dihydronaphthalene-1,4-dione, malononitrile, and fluorinated aromatic aldehyde, 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitrile derivatives have been afforded in good yields (71 – 76 %). The plausible reaction mechanism was described. Products were synthesized through a sequential Knoevenagel condensation, Michael addition, intramolecular cyclization, and [1,3]-hydrogen shift step. The structure of products was completely elucidated by 1H NMR, 13C NMR, and mass spectra. The particularly valuable feature of this process is mild reaction conditions, short reaction times, and good yields.
METHODS OF ASSESSING THE TECHNICAL CONDITION ARTIFICIAL STRUCTURES ON NARROW-GAUGE RAILWAY
Authors: V. Marochka  , О. Marochka  , V. Jurbenko  , Т. Lukhenko  , А. Poznyakov  
Published: December 2023

Purpose. Analysis of the existing structures on the narrow-gauge railways, the research experience of of exploitation of these facilities on the narrow-gauge railways and the development of methodology for assessing the technical condition of the infrastructure of narrow gauge railways in accordance the existing norms. Methodology. Implementation of the expert group inspections and surveys path elements and passenger infrastructure and rolling stock and ancillary industries involved in the operation of the narrow-gauge railway and the assessment of the overall technical condition of the railway track and structures plot narrow-gauge railway in the Carpathian region. Findings. The authors of this study developed a method for assessing the technical condition of infrastructure of narrow gauge railways, which solves most of the issues of operating structures of narrow-gauge railways. Originality. Analysis of existing standards for narrow-gauge railways was held. Surveying of the infrastructure of railways were performed. With this in one normative document it became possible to collect almost all of the basic requirements for the structure and the way to the narrow-gauge railways, it is necessary at the time of the survey, assessing the technical condition and the design, construction and operation of these structures. Practical value. Developed «Methodology to evaluate the technical condition of the infrastructure Narrow Gauge Railway» is the basis for establishing a modern system of operating facilities and the track on the narrow-gauge railways.
OPTIMIZATION OF GEOMETRICAL PARAMETERS OF RUNNING TUNNELS SUPPORT ON THE BASIS OF THE METROGIPROTRANS MODIFIED METHOD
Authors: O. Тiutkin  , М. Umanskaya  
Published: December 2023

Purpose. Applying the Metrogiprotrans modified method it is necessary to correct the developed models so that in subsequent their application gave results which answer of the real conduct of tunnel support at cooperation with a surrounding array. This research allows to execute the scientific ground of the diminished thickness of frame with the receipt of considerable economic effect. Methodology. For the decision of optimization task of running tunnels support geometrical parameters of the Metrogiprotrans method which is modified in accordance with bases of finite elements method is applied. On the basis of the got moments and normal forces the calculation of reinforced concrete elements are executed, the graph is built and dependence of bending moments and normal forces from the thickness of reinforced concrete element is set. Findings. The executed calculations were proved, that the terms of durability are executed for three variants, that diminishment of support thickness does not result in diminishment of block durability, that is explained by possibility of large deformations development toward soil for more pliable support. Development of greater resilient rebuff acts positive part in forming of power factors, here diminishment of amount of armature bars is an important factor, which considerably decreases expenses. Possibility of application of Variant 3 (thickness of element – 15 centimeter, amount of armature bars – 12 things) with the coefficient of the supply 1,6 is most optimum for certain basic data’s of the represented work. Thus, the got results of research give possibility of receipt of bending moments and normal forces dependences from the thickness of reinforced concrete element and ground of running tunnels support geometrical parameters of the Dnepropetrovsk Metro, however needs the considerable complex of researches for the cases of other engineering and geological terms and change of support material. The complete complex of researches puts by a purpose the receipt of the scientifically grounded results which will allow to reduce material charges at building of the Dnepropetrovsk Metro and accordingly economize considerable money facilities. Originality. The collected dependence of bending moments and normal forces from the thickness of reinforced concrete element, which allows for certain soil to execute optimization of running tunnels support geometrical parameters. Practical value. The approaches on decreasing material expenses at building of the Dnepropetrovsk Metro are offered.
Characteristics of adaptive immune effectors involved in the secondary xenogeneic immune response to human melanoma cells
Authors: Persiyantseva N. A. , Kalinina A. A. , Zamkova M.  A. , Khromykh L. M. , Kazansky D. B. 
Published: December 2023

Introduction. Current approaches are being developed for adoptive cancer therapy using T-cells genetically modified with T-cell receptors (TCRs) with specificity for tumor antigens. The complexities of identifying antigen-specific TCRs in a patient’s repertoire and selecting therapeutic receptors necessitate the development of experimental strategies for generating tumor-specific T cells. One of such approaches could be the xenogeneic immunization of mice with human tumor cells. It seems plausible that the T cell repertoire stimulated by xenogeneic vaccination could be a source of TCRs suitable for adoptive cancer immunotherapy.Aim. To assess the prospects for using xenogeneic immunizations to generate tumor-specific memory T cells and identify their TCRs suitable for adoptive immunotherapy, we studied the dynamics of the secondary xenogeneic response in a model of induction of an immune response in mice to human melanoma cells.Materials and methods. Mice were immunized with human melanoma cells, and 45 days later, they were re-challenged with the immunizing tumor. The dynamics of the development of the secondary immune response in vivo and the composition of the involved effectors of adaptive immunity were analyzed by flow cytometry. The proliferation of lymphocytes from immune mice in response to human melanoma cells was evaluated in in vitro culture.Results. The secondary xenogeneic response was characterized by a more intense accumulation of T cells and the rapid development of the effector phase at the injection site of human melanoma. This correlated with an enhanced in vitro proliferative response of lymphocytes from immune animals to xenoantigens of the immunizing tumor. CD4+ and CD8+ memory T cells contributed equally to the development of a secondary response to human melanoma cells expressing HLA class I and II molecules. When only HLA class I was expressed on the cells of the immunizing xenogeneic tumor, CD8+ memory cells were formed, which dominated the secondary immune response.Conclusion. Our findings confirmed the formation of a specific immunological memory for xenoantigens during xenogeneic immunization. This suggests the possibility of generating xenogeneic TCRs specific for human tumor antigens, which opens up opportunities to developing approaches for screening among them for receptor variants suited for adoptive immunotherapy of human cancers.