bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Prostate Cancer Screening Information Quality on Standard and Advanced Versions of ChatGPT, Google Gemini, and Microsoft Copilot: A Cross-Sectional Study
Authors: Owens Otis L. , Leonard Michael 
Published: January 2025

Purpose Artificially Intelligent (AI) chatbots have the potential to produce information to support shared prostate cancer (PrCA) decision-making. Therefore, our purpose was to evaluate and compare the accuracy, completeness, readability, and credibility of responses from standard and advanced versions of popular chatbots: ChatGPT-3.5, ChatGPT-4.0, Microsoft Copilot, Microsoft Copilot Pro, Google Gemini, and Google Gemini Advanced. We also investigated whether prompting chatbots for low-literacy PrCA information would improve the readability of responses. Lastly, we determined if the responses were appropriate for African-American men, who have the worst PrCA outcomes. Approach The study used a cross-sectional approach to examine the quality of responses solicited from chatbots. Participants The study did not include human subjects. Method Eleven frequently asked PrCA questions, based on resources produced by the Centers for Disease Control and Prevention (CDC) and the American Cancer Society (ACS), were posed to each chatbot twice (once for low literacy populations). A coding/rating form containing questions with key points/answers from the ACS or CDC to facilitate the rating process. Accuracy and completeness were rated dichotomously (i.e., yes/no). Credibility was determined by whether a trustworthy medical or health-related organization was cited. Readability was determined using a Flesch-Kincaid readability score calculator that enabled chatbot responses to be entered individually. Average accuracy, completeness, credibility, and readability percentages or scores were calculated using Excel. Results All chatbots were accurate, but the completeness, readability, and credibility of responses varied. Soliciting low-literacy responses significantly improved readability, but sometimes at the detriment of completeness. All chatbots recognized the higher PrCA risk in African-American men and tailored screening recommendations. Microsoft Copilot Pro had the best overall performance on standard screening questions. Microsoft Copilot outperformed other chatbots on responses for low literacy populations. Conclusions AI chatbots are useful tools for learning about PrCA screening but should be combined with healthcare provider advice.
Knowledge, Attitude, Awareness of Organ Donation Among Health Care Professionals: A Prospective Observational Study from Hyderabad
Authors: Kotamarthy Hima Bindu , Sirga Sudeep , Somasekhar DA  , Subba K , Panigrahi Niranjan , Jupally Rajkumar , Gunnampati Karunakar 
Published: January 2025

Background: Deceased organ donation rates in India are alarmingly low. While healthcare workers have the potential to advocate for organ donation within society, their knowledge, attitudes, and practices concerning organ donation have not been extensively studied. Thus, the present study aimed to evaluate the knowledge, attitudes, and practices related to deceased organ donation among healthcare workers, including doctors, nurses, and paramedical staff, by using a pre-structured questionnaire. Methodology: This prospective observational study was conducted using a questionnaire designed to assess the knowledge, attitudes, and practices of healthcare professionals working at a tertiary care centre in Hyderabad. The study included a total of 350 participants. Results: The analysis of questionnaire responses showed that the majority of participants were female (77.4%) and included doctors, nurses, and paramedical staff. Overall, 50.1% of respondents had adequate knowledge about organ donation (scoring above 5), while 49.9% had inadequate knowledge (scoring below 4). Younger respondents (under 40) and males generally scored higher in knowledge. Additionally, 55.6% of participants had a positive attitude towards organ donation, while 44.4% had a negative attitude. Conclusions: Insufficient awareness is impeding the community’s positive attitude towards organ donation, necessitating extensive education and media initiatives to support successful donation and future research.
The effect of computer use on pain, grip strength, and upper limb neural tension in female undergraduate students: A matched-pair study
Authors: Nitayarak Haifah , Toleama Anitya , Madiyoh Nurfatee , Mahae Nooreesan , Pedpak Ranuka , Charntaraviroj Pornpimol 
Published: January 2025

Background Female university students frequently complain of computer-related neck pain after one hour of use, which may cause changes in grip strength and nerve tension in the upper extremity. Objective The purpose of this study was to compare neck pain intensity, grip strength and upper limb neural tension, before and after an hour of computer use between female students with and without neck pain. Method There were 36 female students recruited, which were then divided into the neck pain group (n = 18) and the asymptomatic group (n = 18). Pain intensity, hand grip strength, and neurodynamic testing of the upper extremity were evaluated before and after typing a document on a computer for one hour. Results There was an increase in neck pain, a decrease in grip strength, and an increase in nerve tension of the median, radial, and ulnar nerves after computer use. However, when comparing between groups, the neck pain group had a significantly greater increase in the tension of only the right median and left ulnar nerves compared to the asymptomatic group. Conclusion The current findings demonstrated that an hour spent on a computer can increase neck pain, reduce grip strength, and produce neural tension of upper extremities. However, female students with neck pain had greater increase tension within the median and ulnar nerves, which may result in upper extremity impairment.
Validation of the Turkish version of the second victim experience and support tool- revised (T-SVEST-R)
Authors: Demiray Gamze , Ekuklu Galip 
Published: January 2025

Background Healthcare workers who find themselves entangled in unforeseen adverse patient events, medical errors, and/or patient-related injuries, experiencing trauma and victimization as a consequence of said incidents, are referred to as “second victims”. Objectıve This study aims to validate and assess the reliability of the Turkish version of the Second Victim Experience and Support Tool-Revised (SVEST-R). Methods The methodological and cross-sectional study involved 400 physicians and nurses in an Edirne tertiary hospital of Turkey. The Turkish SVEST-R and a questionnaire were administered, assessing validity through factor analysis and content validity, and reliability through item-total score correlation, internal consistency, and test-retest methods. Results Kaiser-Meyer-Olkin test (0.84) and Bartlett Test (p < 0.001) indicated adequate sampling for factor analysis. Exploratory Factor Analysis identified nine factors explaining 71.58% of total variance. Confirmatory Factor Analysis showed good fit (x2 = 976.95, x2/df = 2.3, CFI = 0.92, GFI = 0.87, RMSEA = 0.05). Cronbach's alpha was 0.85, signifying high internal consistency. Healthcare professionals’ average T-SVEST-R score was 2.8 ± 0.5. Among independent variables, professional experience length significantly influenced T-SVEST-R score. Conclusıons The Turkish version of the Second Victim Experience Support Tool-Revised (T-SVEST-R) has been validated as a reliable scale.
Ergonomic design of foot-operated resistance spot welding interface using multi-criteria decision-making approach
Authors: Alam Md Dilshad , Ali khan Imtiaz 
Published: January 2025

Background Manual spot-welding operators often engage in repetitive motions, awkward postures, and prolonged standing. These factors increase the risk of work-related musculoskeletal disorders (WMSDs), particularly affecting the lower limbs and back. Additionally, inadequate workstation design impacts workers’ health, safety, and productivity. Objective Identify the optimal conditions for the spot-welding interface using a multi-criteria decision-making (MCDM) approach with three input parameters: pedal height (30, 35, 40 cm), worker distance (70, 80, 90 cm) and worksheet thickness (22, 25, 30 gauge). Methods The study employed L27 orthogonal array experimental design. Entropy Weight Method (EWM) was used to determine weight of each factor. The optimal input parameters were identified using Weighted Aggregated Sum Product Assessment (WASPAS) method, with validation from Weighted Grey Relational Analysis (WGRA) and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). Analysis of Variance (ANOVA) determined the significance of input parameters, and a confirmation test validated the findings. Results EWM calculated a weight of 0.3404 to task time, 0.3401 to pedal force, and 0.3193 to comfort level. WASPAS, WGRA, and TOPSIS identified the optimal parameters as pedal height of 35 cm, worker distance of 80 cm, and worksheet thickness of 30-gauge. ANOVA showed that worksheet thickness had the greatest impact on response, followed by worker distance and pedal height. The confirmation test validated the result with high reliability (0.88% error). Conclusion This study explored ergonomic recommendations for optimizing spot-welding environments using a statistical and MCDM model focused on improving pedal force, task time, and comfort.
The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial
Authors: Gupta Ajay , Agarwal Alok 
Published: January 2025

Background Poor posture from work or lifestyle habits is a common cause of low back soreness and discomfort. This study investigates the potential of Rhuleave-K, a turmeric-Boswellia formulation for managing these symptoms. Objective To evaluate the efficacy of Rhuleave-K (500 mg) over 15 days in alleviating posture-related low back soreness and discomfort in human participants. Methods This randomized, placebo-controlled, double-blinded, parallel arm study involved 52 subjects aged 18–70 years, with an equal male to female ratio of 1:1, and a 15 days intervention period. The inclusion criteria were a posture-related low back soreness and discomfort for at least 2–3 weeks with a pain intensity of greater than or equal to 5 on numerical rating scale. The primary outcome measure was a pain intensity difference from baseline to day 7 and day 15. Secondary outcome measures were a categorical pain relief scale and Oswestry disability index (ODI). Results There was a significant decrease in the pain intensity (p < 0.001) compared to placebo at the end of 15 days of study in the Rhuleave-K group. After 7 days of supplementation of Rhuleave-K, there was a 56% reduction in pain intensity and by the end of the study, there was 98.5% reduction. In the responder profile of those having greater than or equal to 50% of max total pain relief, all 26 was in Rhuelave-K group and 3 were in placebo group. The ODI had significant 27% and 98% reduction in the disability index at day 7 and 15 respectively for Rhuleave-K group and placebo group had 1% and 3% change. Conclusion Posture-related low back soreness and discomfort was significantly reduced by Rhuleave-K at 500 mg dose. It is hence evident from this study's outcome that the Rhuleave-K can be a safe and effective alternative for the short-term management of lower back discomfort.
Changes in the craniofacial morphology and hyoid bone position in the neutral and forward head posture in healthy individuals: A cross-sectional study
Authors: Ye Jiling , Jin Lei , Cheng Rongshan , Lv Xiaolong , Yao Yuan , Xu Lili , Cai Bin , Fang Zhongyi , Tsai Tsung-yuan 
Published: January 2025

Background Posture assessment is an important part of clinical physical examination. Head posture changes should be considered in the measurement of the craniofacial morphology and hyoid bone position. Objective To compare the craniofacial morphology and hyoid bone position in the neutral head posture (NHP) and forward head posture (FHP) in healthy individuals. Methods Forty healthy participants (16 men and 24 women) were included in this study. Using lateral cephalograms, we assessed the craniofacial, craniocervical, and hyoid bone positions based on 27 distinct variables. The paired-samples t-test and Pearson's correlation analysis were employed to compare the postures. Results Significant differences in the craniocervical angles were noted between the NHP and FHP. For the hyoid bone position, all parameters except one presented differences. Vertical variables of craniofacial morphology were influenced by head posture. Pearson's correlation coefficients showed that head posture was significantly correlated with craniofacial morphology, particularly for vertical variables. Conclusions This study identified a relationship between the craniocervical and hyoid positions and craniofacial morphology. These findings suggest that different head postures can influence the hyoid position and craniofacial morphology. Hence, for studies involving these parameters and related conditions, maintaining cervical spine posture is crucial.
Effects of Reformer-based Trunk Stability Exercise on Trunk Control, Balance, and Gait Parameters in Patients with Chronic Stroke
Authors: Han Sangyong , Park Donghwan 
Published: January 2025

Background Stroke patients experienced a decline in balance and gait abilities due to impaired trunk control. Previous studies showed that Reformer exercises were effective in improving trunk control. Objective This study aimed to investigate the effects of Reformer-based trunk stability exercises on trunk control, balance, and gait abilities in patients with chronic stroke. Methods This study utilized a randomized controlled trial design. Participants were randomly assigned to an experimental group (Reformer-based trunk stability exercises, n = 12) or a control group (conventional trunk stability exercises, n = 12). The intervention consisted of 20-min sessions conducted five times a week for four weeks. Trunk control, balance, and gait parameters were evaluated before and after the intervention, and the data were analyzed using a two-way repeated measures ANOVA. Results Statistical analysis demonstrated a significant interaction effect between group and time for most variables, with within-group comparisons showing significant differences before and after the intervention for the majority of variables in both groups. Additionally, effect size analysis indicated large effect sizes (Cohen's d > 0.8) for most variables. Conclusions Reformer-based trunk stability exercises showed positive effects on trunk control, balance, and gait parameters in patients with chronic stroke.
Targeted therapy in TNBC: Exploring the role of antibody-drug conjugates with a focus on sacituzumab govitecan
Authors: Siddiqui Nahida , Arun Moduru Tejo , Aparna Kummari , Murthy Madishetti Abhishek , Rao Tadikonda Rama 
Published: January 2025

Objectives To underscore the prevalence and mortality of breast cancer and review advancements in metastatic TNBC management, with a particularly focus on the role of antibody-drug conjugates (ADCs), emphasizing the safety and therapeutic potential of Sacituzumab govitecan (SG) as a groundbreaking ADC. Data Sources This review gathers scientific data from the past decade, sourced from PUBMED, ClinicalTrials.gov, and Google Scholar to retrieve relevant studies focused on SG in metastatic TNBC treatment. Data Summary Breast cancer is the most common cancer in women, with TNBC being particularly aggressive and difficult to treat. Recent advancements, such as ADCs, have enhanced treatment options. The third-generation Trop-2-targeting ADC, SG, shows promise for metastatic TNBC. This review summarizes available scientific data on SG's safety, efficacy, and future potential. It also discusses ongoing clinical trials evaluating SG in various combinations, offering hope for improved therapeutic strategies in this high-risk group. Conclusions ADCs hold great promise for transforming anti-tumor therapies over the next decade and SG has demonstrated substantial efficacy and a manageable safety profile in treating metastatic TNBC. Ongoing trials show that combining SG with immunotherapies enhances its potential, offering hope for better outcomes in patients with limited options. These findings highlight the need for further research to fully define SG's role in optimizing treatment strategies.
Epidemiology, treatment, and mortality of femoral neck fractures in patients over the age of 65 years: a nationwide retrospective cohort study of 83,789 cases in Turkey
Authors: Demirel Mehmet , Birinci Murat , Hakyemez Ömer S , Azboy Nesrullah , Bingöl İzzet , Ata Naim , Mahir Ülgü M , Birinci Şuayip , Ayvalı Mustafa O , Azboy İbrahim , Şen Cengiz 
Published: January 2025

Background: A population-based study delineating the epidemiologic, clinical, and treatment characteristics of femoral neck fractures (FNFs) in elderly patients has not yet been conducted in Turkey. In this nationwide study, the epidemiologic, clinical, and treatment characteristics of patients aged ⩾65 years with FNFs who underwent osteosynthesis, hemiarthroplasty (HA), or total hip arthroplasty (THA) were examined. Methods: Patients aged ⩾65 years with FNFs were identified in this retrospective, nationwide study. Then, the patients who underwent osteosynthesis or total/hemiarthroplasty from 2016 to 2021 were included. All the outcome variables were collected from patient medical records stored in the e-health database of the Republic of Turkey Ministry of Health. Results: A total of 83,789 FNFs treated surgically were analysed. Osteosynthesis was performed on 21,130 FNFs (25.2%), HA on 56,378 FNFs (67.3%), and THA on 6281 FNFs (7.5%). From 2016 to 2021, the overall revision rates for THA and HA were 14.6% (914/5367 patients) and 5.9% (3301/53,077 patients), respectively. The rate of revision prosthetic surgery was significantly higher after THA than after HA ( p  < 0.001). Mortality rates at 1 year were 25% ( n = 5293) for osteosynthesis, 14.7% ( n = 924) for THA, and 71.1% ( n  = 40,109) for HA ( p = 0.001). The multivariate model of 1-year postoperative mortality revealed 7 independent predictors: male sex (odds ratio [OR] 1.694; 95% confidence interval [CI], 1.640–1.751), use of a cemented femoral stem (OR 1.182; 95% CI, 1.117–1.250), acute myocardial infarction (AMI) (OR 1.317; 95% CI, 1.240–1.400), cerebrovascular accident (CVA) (OR 1.379; 95% CI, 1.333–1.425), chronic liver disease (CLD) (OR 2.188; 95% CI, 1.802–2.489), diabetes mellitus (DM) (OR, 1.160; 95% CI, 1.122–1.200), and age >81.50 years (OR 2.654; 95% CI, 2.569–2.742). Conclusions: Our study suggested that a hemiarthroplasty is the most common treatment modality for FNF followed by osteosynthesis (25.2%) and THA (7.5%) in Turkey. Revision rates after THA for FNF are concerning. The 1-year mortality rates are highest after HA, followed by osteosynthesis and THA. Male sex, cemented fixation, CVA, CLD, liver failure, DM, and age >81.50 are the independent predictive factors for postoperative 1-year mortality in this specific group of patients.
Assessment of safety and effectiveness after percutaneous closure for decannulation of Veno-Arterial Extracorporeal Membrane Oxygenation: A systematic review and meta-analysis
Authors: Pereira Tomás Marques , Martins-Fernandes Diana , Ferreira Ana Rita , Guedes da Rocha Henrique , D’Oria Mario , Rocha-Neves João 
Published: January 2025

Introduction: Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) has emerged as a crucial component of critical care medicine, mainly as a lifesaving intervention for patients experiencing refractory cardiac arrest and respiratory failure. Background: In the past, VA-ECMO decannulation was surgical and often associated with a high rate of periprocedural complications, such as surgical site infection, bleeding, and patient mobilization costs. To reduce the rate of these adverse events, many percutaneous techniques utilizing suture-mediated closing devices have been adopted. One of those devices is the Perclose Proglide® (PP). Objective: This study’s goal was to perform a systematic review to evaluate PP devices’ success and complication rates for VA-ECMO decannulation. Methods: To analyze the outcomes of PP in VA-ECMO decannulation, a systematic review of the most recent literature was conducted. The Medline, Web of Science, and Cochrane databases were systematically searched up to September 2023. The National Health, Blood, and Lung Institute Study quality assessment tools were used. Results: The final analysis included 10 observational studies comprising 418 patients. The efficacy of PP in VA-ECMO decannulation was 93.0% (95% CI 90.1%–96.0%). In 381 patients, the incidence of acute limb ischemia after VA-ECMO decannulation was 2.5% (95% CI 0.9%–4.%), the infection of the puncture site after decannulation was 1% (95% CI 0%–2%) in 385 patients. The incidence of patients with pseudoaneurysm after decannulation was 1.1% (95% CI 0.1%–2.1%). Conclusion: This systematic review and meta-analysis demonstrate the safety and efficacy of the PP for achieving hemostasis after VA-ECMO decannulation, with a high success rate and low rate of major complications.
Cliotide U1, a Novel Antimicrobial Peptide Isolated From Urtica Dioica Leaves
Authors: Taheri Mahnaz Nasre , Seyedjavadi Sima Sadat , Goudarzi Mehdi , Ebrahimipour Gholamhossein , Hashemi Ali 
Published: January 2025

Aims: Antibiotic resistance is currently a major challenge to scientists. Thus, attempts have been made to develop new compounds with antimicrobial activity. In this research, a new antimicrobial peptide with antibacterial activity was isolated from the plant Urtica dioica. Methods: A new antimicrobial peptide, named cliotide U1, was purified through precipitation with ammonium sulfate and reverse-phase high-performance liquid chromatography. In silico methods analyzed the physicochemical properties of cliotide U1. The properties of the peptide, including antibacterial activity, pH stability, heat stability, cytotoxicity, and hemolytic activity, were also examined. Findings: The purified peptide was composed of 35 amino acids with a hydrophobicity ratio of 63% and a net charge of + 5. The antibacterial activity of cliotide U1 was observed against gram-negative and gram-positive bacteria with a minimum inhibitory concentration (MIC) of 1 to 4 µM. Cliotide U1 had less than 2% cytotoxic activity at the MIC range against the human embryonic kidney cell line 293 with no clear hemolytic activity. The stability of cliotide U1 was preserved at various temperatures (10-60°C) and pH (6-9). Conclusion: Our results demonstrated that cliotide U1 had potent antibacterial potential against gram-negative and gram-positive bacteria. Considering its properties, cliotide U1 can be introduced as a novel antibacterial candidate for expanding new therapeutic drugs.