bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allosteric substrate activation of SAMHD1 shapes deoxynucleotide triphosphate imbalances by interconnecting the depletion and biosynthesis of different dNTPs
Authors: McCown Claudia , Yu Corey H. , Ivanov Dmitri N. 
Published: November 2023

ABSTRACTSAMHD1 is a dNTPase that impedes replication of HIV-1 in myeloid cells and resting T lymphocytes. Here we elucidate the substrate activation mechanism of SAMHD1 that depends on dNTP binding at allosteric sites and the concomitant tetramerization of the enzyme. The study reveals that SAMHD1 activation involves an inactive tetrameric intermediate with partial occupancy of the allosteric sites. The equilibrium between the inactive and active tetrameric states, which is coupled to cooperative binding/dissociation of at least two allosteric dNTP ligands, controls the dNTPase activity of the enzyme, which, in addition, depends on the identity of the dNTPs occupying the four allosteric sites of the active tetramer. We show how such allosteric regulation determines deoxynucleotide triphosphate levels established in the dynamic equilibria between dNTP production and SAMHD1-catalyzed depletion. Notably, the mechanism enables a distinctive functionality of SAMHD1, which we call facilitated dNTP depletion, whereby elevated biosynthesis of some dNTPs results in more efficient depletion of others. The regulatory relationship between the biosynthesis and depletion of different dNTPs sheds light on the emerging role of SAMHD1 in the biology of dNTP homeostasis with implications for HIV/AIDS, innate antiviral immunity, T cell disorders, telomere maintenance and therapeutic efficacy of nucleoside analogs.
Algal Exudates Promote Conjugation in Marine Roseobacters
Authors: Rapp Yemima Duchin , Lipsman Valeria , Yuda Lilach , Kublanov Ilya V , Matsliyah Dor , Segev Einat 
Published: November 2023

AbstractHorizontal gene transfer (HGT) is a pivotal mechanism driving bacterial evolution, conferring adaptability within dynamic marine ecosystems. Among HGT mechanisms, conjugation mediated by type IV secretion systems (T4SSs) plays a central role in the ecological success of marine bacteria. However, the conditions promoting conjugation events in the marine environment are not well understood. Roseobacters, abundant marine bacteria commonly associated with algae, possess a multitude of T4SSs. Many Roseobacters are heterotrophic bacteria that rely on algal secreted compounds to support their growth. These compounds attract bacteria, facilitating colonization and attachment to algal cells. Algae and their metabolites bring bacteria into close proximity, potentially promoting bacterial HGT. Investigation across various Roseobacters revealed that algal exudates indeed enhance plasmid transfer through conjugation. While algal exudates do not influence the transcription of bacterial conjugative machinery genes, they promote bacterial attachment, potentially stabilizing proximity and facilitating HGT. Notably, under conditions where attachment is less advantageous, the impact of algal exudates on conjugation is reduced. These findings suggest that algae enhance bacterial conjugation primarily by fostering attachment and highlight the importance of studying bacterial HGT within the context of algal-bacterial interactions.
Sensorless robust control for PMSG wind energy conversion systems based on smith predictor ADRC and SMO-PLL estimation
Authors: Benrabah Abdeldjabar , Khoucha Farid , Raza Ali , Benbouzid Mohamed 
Published: November 2023

Purpose
The purpose of this study is to improve the control performance of wind energy conversion systems (WECSs) by proposing a new sensorless, robust control strategy based on a Smith predictor active disturbance rejection control (SP-ADRC) associated with a speed/position estimator.

Design/methodology/approach
The estimator consists of a sliding mode observer (SMO) in combination with a phase-locked loop (PLL) to estimate the permanent magnet synchronous generator (PMSG) rotor position and speed. At the same time, the SP-ADRC is applied to the speed control loop of the variable-speed WECS control system to adapt strongly to dynamic characteristics under parameter uncertainties and disturbances.

Findings
Numerical simulations are conducted to evaluate the speed tracking performances under various wind speed profiles. The results show that the proposed sensorless speed control improves the accuracy of rotor speed and position estimation and provides better power tracking performance than a regular ADRC controller under fast wind speed variations.

Practical implications
This paper offers a new approach for designing sensorless, robust control for PMSG-based WECSs.

Originality/value
A new sensorless, robust control is proposed to improve the stability and tracking performance of PMSG-based WECSs. The SP-ADRC control attenuates the effects of parameter uncertainties and disturbances and eliminates the time-delay impact. The sensorless control design based on SMO and PLL improves the accuracy of rotor speed estimation and reduces the chattering problem of traditional SMO. The obtained results support the theoretical findings.
Turnover intention among Vietnamese millennials in the workplace
Authors: Yang Yumei , Thu Hue Hannah Mai , Takeda Sachiko 
Published: November 2023

PurposeDrawing upon the framework of social exchange theory, this study investigated the influence of work-life balance, procedural justice and distributive justice on job satisfaction and turnover intention among Vietnamese millennials.Design/methodology/approachEmploying a quantitative research method, the authors collected a sample of 258 millennial participants in Vietnam. Utilizing the method of multiple regression analysis, the collected data were rigorously examined.FindingsThe results showed that job satisfaction is negatively related to the turnover intention of the millennial generation in Vietnam. Distributive justice is a stronger predictor of job satisfaction than procedural justice. Of particular note, the study revealed an intriguing result: work-life balance does not have a significant influence on job satisfaction among millennials.Practical implicationsLeveraging insights from national cultural theories, the authors' findings provide some insightful explanations of what drives millennials in Vietnam to consider leaving their organizations.Social implicationsThe study provides some insights for policymakers in Vietnam and other similar developing countries to reform their approach at managing the millennial generation.Originality/valueThe research addresses the existing gap in literature by delving into the underlying factors driving the propensity of Vietnamese millennials to frequently switch jobs.
The impact of financial support on forestry green total factor productivity from the perspective of environmental regulation
Authors: Wu Haotian , Chen Jiancheng , Bai Wanting , Fang Yiliang 
Published: November 2023

PurposeThe aim of this article is to research on forestry green total factor productivity and explore the impact of financial support on forestry green total factor productivity.Design/methodology/approachThe methods used in this study are super efficiency SBM model of undesired output and empirical model. SBM model is a kind of Data Envelopment Analysis (DEA). The SBM model with non-expected outputs (slacks-based measure) can be used to deal with the problem of efficiency measurement with multiple input and output variables and can be used to analyze the efficiency of green development of forestry economy.FindingsFirst, the overall green total factor productivity of the authors’ country's forestry has shown a trend of first decline and then an increase from 2008 to 2018, and there are significant spatiotemporal differences; second, financial support has a significant positive impact on forestry green total factor productivity; third, environmental regulation has a significant threshold effect in the process of financial support on forestry green total factor productivity, and the role of financial support shows a trend of first increasing and then decreasing.Originality/valueSecondly, taking the data of 30 provinces and cities in the authors’ country from 2008 to 2018 as the research object, using the super-efficiency SBM-Malmquist index to measure the country's forestry green total factor productivity and analyze its temporal and spatial changes; finally, a dynamic panel model was established to explore the impact of financial support on forestry green total factors quantitative impact on productivity, and adding environmental regulation as a threshold variable to establish a dynamic threshold regression, and found that financial support has a nonlinear impact on forestry green total factor productivity.
Analysis of software promotion strategies in product-service integrated supply chains
Authors: Li Kai , Xia Lulu , Zhao Nenggui , Zhou Tao 
Published: November 2023

PurposeThe purpose of this paper is to compare the pricing decisions and earning potential of the software supplier and the smart device manufacturer in different software promotion strategies.Design/methodology/approachBased on game theory, the authors formulate two promotion models, that is, the supplier implements software promotion activities individually (SP model) or outsources the promotion activity to the manufacturer under profit-sharing contract (MP model) when taking different channel power structures into consideration. Besides, in order to test the robustness of the conclusions, the authors also extend the basic model to the following situations: (1) the customers have different price elasticity toward service fee and product price; (2) the revenue sharing contract is employed by the supply chain members; and (3) the manufacturer's product promotion practice is taken into consideration.FindingsThe optimal service fee (product price) of the supplier (manufacturer) under SP model is always lower (higher) than that under MP model. Surprisingly, if the supplier is the channel leader and the profit sharing ratio exceeds certain threshold, the manufacturer's profit decreases in profit sharing ratio, which remains robust in three extension models. Moreover, the supply chain's profit in supplier-led game is always lower than that in Nash game irrespective of the promotion strategy in profit sharing context. When revenue sharing contract is adopted, the result holds only when the revenue sharing ratio is relatively low.Originality/valueThe authors originally explore two promotion strategies of the software supplier when taking the channel power structures into considerations, which has not been explored in the literature to the best of the authors' knowledge.
CEO overconfidence and financial reporting complexity: evidence from textual analysis
Authors: Rajabalizadeh Javad 
Published: November 2023

PurposeThis study investigates the relationship between the Chief Executive Officer's (CEO) overconfidence and financial reporting complexity in Iran, a context characterized by weak corporate governance and heightened managerial discretion.Design/methodology/approachThe sample consists of 1,445 firm-year observations from 2010 to 2021. CEO overconfidence (CEOOC) is evaluated using an investment-based index, specifically capital expenditures. Financial reporting complexity (Complexity) is measured through textual features, particularly three readability measures (Fog, SMOG and ARI) extracted from annual financial statements. The ordinary least squares (OLS) regression is employed to test the research hypothesis.FindingsResults suggest that CEOOC is positively related to Complexity, leading to reduced readability. Additionally, robustness analyses demonstrate that the relationship between CEOOC and Complexity is more distinct and significant for firms with lower profitability than those with higher profitability. This implies that overconfident CEOs in underperforming firms tend to increase complexity. Also, firms with better financial performance present a more positive tone in their annual financial statements, reflecting their superior performance. The findings remain robust to alternative measures of CEOOC and Complexity and are consistent after accounting for endogeneity issues using firm fixed-effects, propensity score matching (PSM), entropy balancing approach and instrumental variables method.Research limitations/implicationsThis study adds to the literature by delving into the effect of CEOs' overconfidence on financial reporting complexity, a facet not thoroughly investigated in prior studies. The paper pioneers the use of textual analysis techniques on Persian texts, marking a unique approach in financial reporting and a first for the Persian language. However, due to the inherent challenges of text mining and feature extraction, the results should be approached with caution.Practical implicationsThe insights from this study can guide investors in understanding the potential repercussions of CEOOC on financial reporting complexity. This will assist them in making informed investment decisions and monitoring the financial reporting practices of their invested companies. Policymakers and regulators can also reference this research when formulating policies to enhance financial reporting quality and ensure capital market transparency. The innovative application of textual analysis in this study might spur further research in other languages and contexts.Originality/valueThis research stands as the inaugural study to explore the relationship between CEOs' overconfidence and financial reporting complexity in both developed and developing capital markets. It thereby broadens the extant literature to include diverse capital market environments.
Wheel/rail-force–based maintenance interval extension of the C80 series wagon
Authors: Xiao Qi , Yu Weidong , Tian Guangrong , Li Fangxuan 
Published: November 2023

PurposeThis study aims to introduce the achievements and benefits of applying wheel/rail-force–based maintenance interval extension of the C80 series wagon in China.Design/methodology/approachChinese wagons' existing maintenance strategy had left a certain safety margin for the characteristics of widely running range, unstable service environment and submission to transportation organization requirements. To reduce maintenance costs, China railway (CR) has attempted to extend the maintenance interval since 2020. The maintenance cycle of C80 series heavy haul wagons is extended by three months (no stable routing) or 50,000 km (regular routing). However, in the meantime, the alarming rate of the running state, a key index to reflect the severe degree of hunting stability, by the train performance detection system (TPDS) for the C80 series heavy haul wagons has increased significantly.FindingsThe present paper addresses a big data statistical way to evaluate the risk of allowing the C80 series heavy haul wagons to remain in operation longer than stipulated by the maintenance interval initial set. Through the maintenance and wayside-detector data, which is divided into three stages, the extension period (three months), the current maintenance period and the previous maintenance period, this method reveals the alarming rate of hunting was correlated with maintenance interval. The maintainability of wagons will be achieved by utilizing wagon performance degradation modeling with the state of the wheelset and the often-contact side bearing. This paper also proposes a statistical model to return to the average safety level of the previous maintenance period's baseline through correct alarming thresholds for unplanned corrective maintenance.Originality/valueThe paper proposes an approach to reduce safety risk due to maintenance interval extension by effective maintenance program. The results are expected to help the railway company make the optimal solution to balance safety and the economy.
Burning questions: Exploring the limits of microbial electrochemical technology for industrial biotechnological applications
Authors: Lai Bin 
Published: November 2023

AbstractMicrobial electrochemical technology (MET) has proven to be a promising solution to overcome the redox and energy metabolic constraints, enabling high yields of biosynthesis beyond stoichiometric limits. While there is room for improvement in extracellular electron transfer rates and productivity of the target compounds, it is crucial to think in advance about which bioprocess could be electrified and what would face major challenges. In this opinion paper, I presented and addressed interfacial electron transfer capacity of MET, whether built on biofilm or planktonic cells, and also discussed the upper limits of the MET system for biosynthesis of chemicals accordingly. Potential future application scenarios of different MET were also briefly addressed. This opinion paper aims to encourage the community to rethink the design and development of microbial electrochemical technologies for potential future applications in industrial biotechnology.
Low‐risk gestational trophoblastic neoplasia – 20 years experience of a state registry
Authors: McInerney Carmel , McNally Orla , Cade Thomas James , Jones Antonia , Neesham Deborah , Naaman Yael 
Published: November 2023

BackgroundGestational trophoblastic disease (GTD) is an uncommon but highly treatable condition. There is limited local evidence to guide therapy.AimsTo report the experience of a statewide registry in the treatment of low‐risk gestational trophoblastic neoplasia (GTN) over a 20‐year period.Materials and MethodsA retrospective review of the prospectively maintained GTD registry database was conducted. There were 144 patients identified with low‐risk GTN, of which 115 were analysed. Patient demographics, treatment details and outcomes, including development of resistance, toxicity or relapse were reviewed.ResultsThe incidence of GTD was 2.6/1000 live births. There was 100% survival. The mean time from diagnosis to commencing treatment was 1.9 days (range 0–29 days). Seventy‐seven percent of patients treated with methotrexate achieved complete response. Thirteen patients (11.3%) required multi‐agent chemotherapy, for the treatment of resistant or relapsed disease. There was a higher rate of treatment resistance in those with World Health Organization (WHO) risk scores 5–6 (odds ratio (OR) 6.56, 95% CI 1.73–24.27, P = 0.005) and those with pre‐treatment human chorionic gonadotropin >10 000 (OR 4.00 95% CI 1.73–24.27 P = 0.007). Four patients (3.5%) were diagnosed with choriocarcinoma after commencing treatment. Nine patients (7.8%) had successful surgical treatment for GTN, both alone and in combination with chemotherapy. The relapse rate was 4.3%; all were treated successfully with a combination of chemotherapy and surgery, and 93.9% of patients completed follow up through the registry.ConclusionsMethotrexate is a highly effective treatment for low‐risk GTN, especially with WHO risk score ≤4. The optimal treatment for those with risk scores of 5–6 requires further investigation.
I help, therefore, I am?—longitudinal interrelations of the three‐dimensional moral self‐concept and prosocial behaviours in 4–6‐year‐old children
Authors: Söldner Lena , Paulus Markus 
Published: November 2023

AbstractChildren's moral self‐concept (MSC) has been proposed to relate to prosocial behaviour. However, systematic assessments of their interrelations are scarce. The current study examines the early development, structure, stability and interrelation of three key prosocial behaviours and the corresponding dimensions of the moral self‐concept. To this end, we use a longitudinal approach with three measurement points during the preschool years at ages 4, 5 and 6 years. We assess three prosocial dimensions of children's MSC through a puppet‐interview. In addition, behavioural measures of children's helping, sharing and comforting were administered in a laboratory setting. By examining the longitudinal associations between MSC and prosocial behaviours, this study will provide valuable insights into the complex nature of prosocial development in early childhood.
Identification of novel targets for immunotherapies in subsets of patients with diffuse large B‐cell lymphoma (DLBCL)
Authors: Heini Alexander D. , Bacher Ulrike , Pabst Thomas 
Published: November 2023

Personalized treatment options for subsets of patients with DLBCL are beginning to emerge. Caracciolo et al. explore UMG1, an epitope of CD43 as a potential target for certain patients with DLBCL, and demonstrate promising preclinical activity of an Anti‐UMG1‐antibody.Commentary on: Caracciolo et al. UMG1/CD3ε‐bispecific T‐cell engager (BTCE) redirects T‐cell cytotoxicity against diffuse large B‐cell lymphoma (DLBCL). Br J Haematol 2024;204:555‐560.
Keratoconus in Down syndrome: Prevalence, risk factors, severity and corneal tomographic characteristics
Authors: Mathan Joyce J. , Gokul Akilesh , Simkin Samantha K. , Meyer Jay J. , McGhee Charles N. J. 
Published: November 2023

AbstractBackgroundThis study investigated the prevalence, risk factors and severity of corneal tomographic features of keratoconus in Down syndrome (DS). Additionally, previous studies indicate anomalous corneal features in DS, without keratoconus, this study characterised corneal features in DS without keratoconus.MethodsThis prospective observational study included participants with DS ≥10 years old. Keratoconus diagnosis, risk factors and corneal tomographic characteristics were recorded. Participants underwent slit‐lamp biomicroscopy, Scheimpflug corneal tomography, corneal topography and autorefraction. A diagnosis of keratoconus (DS‐KC), suspect keratoconus (DS‐SK) and non‐keratoconus (DS‐NK) was made based on expert review of scans by three fellowship trained anterior segment ophthalmologists. Corneal tomography parameters from one eye of each participant were analysed.ResultsKeratoconus affected 50 (26.3%) of 190 participants, diagnosed by corneal tomography, topography or slit‐lamp signs. Corneal hydrops affected 14.0% of DS‐KC participants. Eye rubbing was a significant risk factor for keratoconus (p = 0.036). 175 (92%) participants could undertake corneal tomography of which tomography assessment alone identified 47 (26.9%) DS‐KC participants, 64 (36.6%) DS‐SK participants and 64 (36.6%) DS‐NK participants. Significant differences (p < 0.001) were identified when the DS‐KC, DS‐SK and DS‐NK groups were compared in maximum keratometry and posterior elevation at the thinnest point respectively: median (interquartile range) 50.20 (10.30D), 47.60 (1.95D), 46.50 (2.40D); 24.0 (38.00 μm), 10.00 (13.75 μm), 8.00 (6.00 μm). The DS‐SK and DS‐NK cohorts had similar minimum pachymetry, however, had several significantly different parameters among which included greater maximum keratometry, posterior elevation at the thinnest point in the DS‐SK group.ConclusionsKeratoconus is common in DS. Keratoconus screening with corneal tomography is recommended for early detection.