bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cassini’s CDA observes a variety of dust populations just outside Saturn’s main rings
Authors: Linti Simon , Khawaja Nozair , Hillier Jon K , Nölle Lenz , Fischer Christian , Hsu Hsiang-Wen , Srama Ralf , Postberg Frank 
Published: January 2024

ABSTRACT
Before the end of its mission, the Cassini spacecraft orbited Saturn in a series of highly inclined elliptical ‘Ring-Grazing’ orbits (RGO). During the RGO, the spacecraft passed repeatedly through the ring plane outside the F ring, near the orbits of Janus and Epimetheus, at an average relative speed of ∼20 km s–1. For the first time, Cassini’s Cosmic Dust Analyser (CDA) directly sampled dust particles from this region. Here, we analyse the compositions of dust grains sampled within ±15 min relative to nine ring plane crossings of the RGO. The compositions of most analysed RGO grains are similar to those of E ring ice grains, implying that the E ring extends to within at least 2.45 Saturn radii (RS) of Saturn. The compositional distribution of these grains point at a similar average period (decades) since ejection from Enceladus as of particles in the outer E ring (beyond 8 RS). Higher fractions of larger grains are found near the orbits of Janus and Epimetheus, which probably represent ejecta from these moons. Most of these grains have compositions similar to the background E ring grains, indicating that E ring material is coating the surfaces of Janus and Epimetheus. We also report the detection of several types of mineral grains on prograde orbits, one of which, a water ice/silicate mixture, has never been observed by CDA elsewhere. These mineral grains appear to have a different origin from the E ring, and may arise from nearby moons, the F ring, or main rings.
Exploring the influence of the ‘Smiley Sun’ on the dynamics of inner solar corona and near-Earth space environment
Authors: Jain Richa N , Choudhary R K , Imamura T 
Published: January 2024

ABSTRACT
The image captured by SDO/AIA (Solar Dynamics Observatory) in the 193 Å ultraviolet channel from 2022 October 25–27, unveiled a remarkable trio of dark coronal holes near the heliocentric equator, forming a distinctive smiling face. Serendipitously, during that period, coronal radio science experiments were being conducted using the Akatsuki spacecraft to investigate turbulence regimes in the inner-middle corona and track the acceleration of solar wind streams. By analysing Doppler frequency residuals, we derived valuable insights into plasma turbulence characteristics, estimated electron density fluctuations and flow speeds using isotropic quasi-static turbulence methods. The analysis consistently unveiled a shallow turbulence spectrum and flow speeds ranging from 180 to 400 km s−1 at heliocentric distances of 3–9 Rs. During this period, the solar wind flow speed, recorded at the L1 point near Earth, was of the order of 600–650 km s−1. This presented a unique opportunity to delve into turbulence within the inner corona and explore the mechanisms responsible for energizing and accelerating high-speed streams emanating from these trans-equatorial coronal holes. The study also suggests the innovative use of spacecraft signals as radio beacons for enhanced forecasting of potential space weather events triggered by Earth-directed high-speed solar wind streams.
Mixed Patterns of Intergenerational DNA Methylation Inheritance in Acropora
Authors: Peterson Christopher R , Scott Carly B , Ghaffari Rashin , Dixon Groves , Matz Mikhail V 
Published: January 2024

Abstract
For sessile organisms at high risk from climate change, phenotypic plasticity can be critical to rapid acclimation. Epigenetic markers like DNA methylation are hypothesized as mediators of plasticity; methylation is associated with the regulation of gene expression, can change in response to ecological cues, and is a proposed basis for the inheritance of acquired traits. Within reef-building corals, gene-body methylation (gbM) can change in response to ecological stressors. If coral DNA methylation is transmissible across generations, this could potentially facilitate rapid acclimation to environmental change. We investigated methylation heritability in Acropora, a stony reef-building coral. Two Acropora millepora and two Acropora selago adults were crossed, producing eight offspring crosses (four hybrid, two of each species). We used whole-genome bisulfite sequencing to identify methylated loci and allele-specific alignments to quantify per-locus inheritance. If methylation is heritable, differential methylation (DM) between the parents should equal DM between paired offspring alleles at a given locus. We found a mixture of heritable and nonheritable loci, with heritable portions ranging from 44% to 90% among crosses. gBM was more heritable than intergenic methylation, and most loci had a consistent degree of heritability between crosses (i.e. the deviation between parental and offspring DM were of similar magnitude and direction). Our results provide evidence that coral methylation can be inherited but that heritability is heterogenous throughout the genome. Future investigations into this heterogeneity and its phenotypic implications will be important to understanding the potential capability of intergenerational environmental acclimation in reef building corals.
Dynamic Phytomeric Growth Contributes to Local Adaptation in Barley
Authors: Huang Yongyu , Maurer Andreas , Giehl Ricardo F H , Zhao Shuangshuang , Golan Guy , Thirulogachandar Venkatasubbu , Li Guoliang , Zhao Yusheng , Trautewig Corinna , Himmelbach Axel , Börner Andreas , Jayakodi Murukarthick , Stein Nils , Mascher Martin , Pillen Klaus , Schnurbusch Thorsten 
Published: January 2024

AbstractVascular plants have segmented body axes with iterative nodes and internodes. Appropriate node initiation and internode elongation are fundamental to plant fitness and crop yield; however, how these events are spatiotemporally coordinated remains elusive. We show that in barley (Hordeum vulgare L.), selections during domestication have extended the apical meristematic phase to promote node initiation, but constrained subsequent internode elongation. In both vegetative and reproductive phases, internode elongation displays a dynamic proximal—distal gradient, and among subpopulations of domesticated barleys worldwide, node initiation and proximal internode elongation are associated with latitudinal and longitudinal gradients, respectively. Genetic and functional analyses suggest that, in addition to their converging roles in node initiation, flowering-time genes have been repurposed to specify the timing and duration of internode elongation. Our study provides an integrated view of barley node initiation and internode elongation and suggests that plant architecture should be recognized as a collection of dynamic phytomeric units in the context of crop adaptive evolution.
GSDMD and GSDME synergy in the transition of acute kidney injury to chronic kidney disease
Authors: Chen Zhengyue , Chen Caiming , Lai Kunmei , Wu Chengkun , Wu Fan , Chen Zhimin , Ye Keng , Xie Jingzhi , Ma Huabin , Chen Hong , Wang Yujia , Xu Yanfang 
Published: January 2024

ABSTRACT

Background and hypothesis
Acute kidney injury (AKI) could progress to chronic kidney disease (CKD) and the AKI-CKD transition has major clinical significance. A growing body of evidence has unveiled the role of pyroptosis in kidney injury. We postulate that GSDMD and GSDME exert cumulative effects on the AKI-CKD transition by modulating different cellular responses.

Methods
We established an AKI-CKD transition model induced by folic acid in wildtype (WT), Gsdmd−/−, Gsdme−/−, and Gsdmd−/−Gsdme−/− mice. Tubular injury, renal fibrosis and inflammatory responses were evaluated. In vitro studies were conducted to investigate the interplay among tubular cells, neutrophils, and macrophages.

Results
Double deletion of Gsdmd and Gsdme conferred heightened protection against AKI, mitigating inflammatory responses, including the formation of neutrophil extracellular traps (NETs), macrophage polarization and differentiation, and ultimately renal fibrosis, compared with wildtype mice and mice with single deletion of either Gsdmd or Gsdme. Gsdme, but not Gsdmd deficiency, shielded tubular cells from pyroptosis. GSDME-dependent tubular cell death stimulated NETs formation and prompted macrophage polarization towards a pro-inflammatory phenotype. Gsdmd deficiency suppressed NETs formation and subsequently hindered NETs-induced macrophage-to-myofibroblast transition (MMT).

Conclusion
GSDMD and GSDME collaborate to contribute to AKI and subsequent renal fibrosis induced by folic acid. Synchronous inhibition of GSDMD and GSDME could be an innovative therapeutic strategy for mitigating the AKI-CKD transition.
Long-term health-related quality of life in meningioma survivors: A mixed-methods systematic review
Authors: Frances Sé Maria , Murray Louise , Nicklin Emma , Velikova Galina , Boele Florien 
Published: January 2024

Abstract

Background
Meningiomas account for ~25% of all primary brain tumors. These tumors have a relatively favorable prognosis with ~92% of meningioma patients surviving &gt;5 years after diagnosis. Yet, patients can report high disease burden and survivorship issues even years after treatment, affecting health-related quality of life (HRQOL). We aimed to systematically review the literature and synthesize evidence on HRQOL in meningioma patients across long-term survival, defined as ≥2 years post-diagnosis.

Methods
Systematic literature searches were carried out using Medline, EMBASE, CINAHL, PsycINFO, and Web of Science Core Collection. Any published, peer-reviewed articles with primary quantitative, qualitative, or mixed-methods data covering the physical, mental, and/or social aspects of HRQOL of meningioma survivors were included. A narrative synthesis method was used to interpret the findings.

Results
Searches returned 2253 unique publications, of which 21 were included. Of these, N = 15 involved quantitative methodology, N = 4 mixed methods, and N = 2 were qualitative reports. Patient sample survival ranged from 2.75 to 13 years. HRQOL impairment was seen across all domains. Physical issues included persevering symptoms (eg, headaches, fatigue, vision problems); mental issues comprised emotional burden (eg, high prevalence of depressive symptoms and anxiety) and cognitive complaints; social issues included role limitations, social isolation, and affected work productivity. Due to study heterogeneity, the impact of treatment on long-term HRQOL remains unclear.

Conclusions
The findings from this review highlight the areas of HRQOL that can be impacted in long-term survivorship for patients with meningioma. These findings could help raise awareness among clinicians and patients, facilitating support provision.
Negative enthalpy alloys and local chemical ordering: a concept and route leading to synergy of strength and ductility
Authors: An Zibing , Yang Tao , Shi Caijuan , Mao Shengcheng , Wang Lihua , Li Ang , Li Wei , Xue Xianmeng , Sun Ming , Bai Yifan , He Yapeng , Ren Fuzeng , Lu Zhouguang , Yan Ming , Ren Yang , Liu Chain-Tsuan , Zhang Ze , Han Xiaodong 
Published: January 2024

ABSTRACT
Solid solutions are ubiquitous in metals and alloys. Local chemical ordering (LCO) is a fundamental sub-nano/nanoscale process that occurs in many solid solutions and can be used as a microstructure to optimize strength and ductility. However, the formation of LCO has not been fully elucidated, let alone how to provide efficient routes for designing LCO to achieve synergistic effects on both superb strength and ductility. Herein, we propose the formation and control of LCO in negative enthalpy alloys. With engineering negative enthalpy in solid solutions, genetic LCO components are formed in negative enthalpy refractory high-entropy alloys (RHEAs). In contrast to conventional ‘trial-and-error’ approaches, the control of LCO by using engineering negative enthalpy in RHEAs is instructive and results in superior strength (1160 MPa) and uniform ductility (24.5%) under tension at ambient temperature, which are among the best reported so far. LCO can promote dislocation cross-slip, enhancing the interaction between dislocations and their accumulation at large tensile strains; sustainable strain hardening can thereby be attained to ensure high ductility of the alloy. This work paves the way for new research fields on negative enthalpy solid solutions and alloys for the synergy of strength and ductility as well as new functions.
Stereoselective recognition of morphine enantiomers by μ-opioid receptor
Authors: Wang Yibo , Ngo Van A , Wang Xiaohui 
Published: January 2024

ABSTRACT
Stereospecific recognition of chiral molecules plays a crucial role in biological systems. The μ-opioid receptor (MOR) exhibits binding affinity towards (−)-morphine, a well-established gold standard in pain management, while it shows minimal binding affinity for the (+)-morphine enantiomer, resulting in a lack of analgesic activity. Understanding how MOR stereoselectively recognizes morphine enantiomers has remained a puzzle in neuroscience and pharmacology for over half-a-century due to the lack of direct observation techniques. To unravel this mystery, we constructed the binding and unbinding processes of morphine enantiomers with MOR via molecular dynamics simulations to investigate the thermodynamics and kinetics governing MOR's stereoselective recognition of morphine enantiomers. Our findings reveal that the binding of (−)-morphine stabilizes MOR in its activated state, exhibiting a deep energy well and a prolonged residence time. In contrast, (+)-morphine fails to sustain the activation state of MOR. Furthermore, the results suggest that specific residues, namely D1142.50 and D1473.32, are deprotonated in the active state of MOR bound to (−)-morphine. This work highlights that the selectivity in molecular recognition goes beyond binding affinities, extending into the realm of residence time.
Digital Smoking Cessation With a Comprehensive Guideline-Based App—Results of a Nationwide, Multicentric, Parallel, Randomized Controlled Trial in Germany
Authors: Rupp Alexander , Rietzler Stephan , Di Lellis Maddalena A , Weiland Timo , Tschirner Claudia , Kreuter Michael 
Published: January 2024

Abstract

Background
Smoking tobacco implies significant health hazards. Digital cessation support can get more smokers in contact with guideline-based cessation. The objective was to test the efficacy of a guideline-based smoking cessation app (NichtraucherHelden®). The hypothesis was a significantly higher cessation rate in the intervention group.

Methods
The study was a nationwide, multicentric, prospective, parallel, randomized controlled trial in Germany from November 2021 to March 2023. Recruitment took place in medical practices and by telephone via study centers. Eligible participants were adult tobacco-dependent smokers according to ICD-10 (F17.2). Randomization (1:1) was operated by a computer-generated stratified 1:1 block procedure. Intervention (IG; n = 336) and control group (CG; n = 325) were briefly advised with regard to stop smoking, IG was additionally treated with the cessation app. The primary endpoint was the self-reported 7-day-point abstinence after 6 months with an intention to treat analysis. Secondary endpoints comprised prolonged abstinence and biochemically verified abstinence. The study was registered at the German Registry of Clinical Trials (DRKS00025933, UTN U1111-1268-2181) and was approved by the competent ethics committees (leading ethic committee Berlin #Eth-52/20).

Results
Three hundred thirty six participants (IG) and 325 (CG) were analyzed. Seven-day point prevalence was significantly higher in the app group (IG) (20% vs. 10%, OR 2.2 (1.4–3.4)). Additionally, the prolonged abstinence and the objective abstinence rates were significantly higher in the app group.

Conclusions
The NichtraucherHelden app doubles the abstinence rate. Apps can bridge the gap between the small number of therapeutic offers and the need for modern evidence-based cessation support.

Implications
The study is the first to provide evidence for the feasibility and efficacy of guideline-based digital smoking cessation provided by a smartphone app for the German statutory health insurance (SHI) system. Smoking cessation support by smartphone apps could be broadly distributed and thus bring more smokers in contact with guideline-based cessation support than to date and increase the number of successful quitters substantially.
Magnitude and Durability of the Antibody Response to mRNA-Based Vaccination Among SARS-CoV-2 Seronegative and Seropositive Health Care Personnel
Authors: Ciccone Emily J , Zhu Deanna R , Gunderson Annika K , Hawke Sam , Ajeen Rawan , Lodge Evans K , Shook-Sa Bonnie E , Abernathy Haley , Garrett Haley E , King Elise , Alavian Naseem , Reyes Raquel , Taylor Jasmine L , Beatty Cherese , Chung Christy , Mendoza Carmen E , Weber David J , Markmann Alena J , Premkumar Lakshmanane , Juliano Jonathan J , Boyce Ross M , Aiello Allison E 
Published: January 2024

Abstract
Few studies have described changes in SARS-CoV-2 antibody levels in response to infection and vaccination at frequent intervals and over extended follow-up periods. The purpose of this study was to assess changes in SARS-CoV-2–specific antibody responses among a prospective cohort of health care personnel over 18 months with up to 22 samples per person. Antibody levels and live virus neutralization were measured before and after mRNA-based vaccination with results stratified by (1) SARS-CoV-2 infection status prior to initial vaccination and (2) SARS-CoV-2 infection at any point during follow-up. We found that the antibody response to the first dose was almost 2-fold higher in individuals who were seropositive prior to vaccination, although neutralization titers were more variable. The antibody response induced by vaccination appeared to wane over time but generally persisted for 8 to 9 months, and those who were infected at any point during the study had slightly higher antibody levels over time vs those who remained uninfected. These findings underscore the need to account for SARS-CoV-2 natural infection as a modifier of vaccine responses, and they highlight the importance of frequent testing of longitudinal antibody titers over time. Together, our results provide a clearer understanding of the trajectories of antibody response among vaccinated individuals with and without prior SARS-CoV-2 infection.
The new insights of hyperbaric oxygen therapy: focus on inflammatory bowel disease
Authors: Chen Leilei , Wang Yan , Zhou Huihui , Liang Yi , Zhu Fengqin , Zhou Guangxi 
Published: January 2024

Abstract
Inflammatory bowel diseases (IBD), with an increasing incidence, pose a significant health burden. Although there have been significant advances in the treatment of IBD, more progress is still needed. Hyperbaric oxygen therapy (HBOT) has been shown to treat a host of conditions such as carbon monoxide poisoning, decompression sickness, and gas gangrene. In the last few years, there has been an increase in research into the use of HBOT as an adjunct to conventional treatment for IBD. Related research has shown that HBOT may exert its therapeutic effects by decreasing oxidative stress, inhibiting mucosal inflammation, promoting ulcer healing, influencing gut microbes, and reducing the incidence of IBD complications. This paper aims to provide a comprehensive review of experimental and clinical trials exploring HBOT as a supplement to IBD treatment strategies.
Opioid therapy trajectories of patients with chronic non-cancer pain over 1 year of follow-up after initiation of short-acting opioid formulations
Authors: Acharya Mahip , Hayes Corey J , Li Chenghui , Painter Jacob T , Dayer Lindsey , Martin Bradley C 
Published: January 2024

Abstract

Objective
This study compared opioid utilization trajectories of persons initiating tramadol, short-acting hydrocodone, or short-acting oxycodone, and it characterized opioid dose trajectories and type of opioid in persistent opioid therapy subsamples.

Methods
A retrospective cohort study of adults with chronic non-cancer pain who were initiating opioid therapy was conducted with the IQVIA PharMetrics® Plus for Academics data (2008–2018). Continuous enrollment was required for 6 months before (“baseline”) and 12 months after (“follow-up”) the first opioid prescription (“index date”). Opioid therapy measures were assessed every 7 days over follow-up. Group-based trajectory modeling (GBTM) was used to identify trajectories for any opioid and total morphine milligram equivalent measures, and longitudinal latent class analysis was used for opioid therapy type.

Results
A total of 40 276 tramadol, 141 023 hydrocodone, and 45 221 oxycodone initiators were included. GBTM on any opioid therapy identified 3 latent trajectories: early discontinuers (tramadol 39.0%, hydrocodone 54.1%, oxycodone 61.4%), late discontinuers (tramadol 37.9%, hydrocodone 39.4%, oxycodone 33.3%), and persistent therapy (tramadol 6.7%, hydrocodone 6.5%, oxycodone 5.3%). An additional fourth trajectory, intermittent therapy (tramadol 16.4%), was identified for tramadol initiators. Of those on persistent therapy, 2687 individuals were on persistent therapy with tramadol, 9169 with hydrocodone, and 2377 with oxycodone. GBTM on opioid dose resulted in 6 similar trajectory groups in each persistent therapy group. Longitudinal latent class analysis on opioid therapy type identified 6 latent classes for tramadol and oxycodone and 7 classes for hydrocodone.

Conclusion
Opioid therapy patterns meaningfully differed by the initial opioid prescribed, notably the presence of intermittent therapy among tramadol initiators and higher morphine milligram equivalents and prescribing of long-acting opioids among oxycodone initiators.
Minor intron–containing genes as an ancient backbone for viral infection?
Authors: Wuchty Stefan , White Alisa K , Olthof Anouk M , Drake Kyle , Hume Adam J , Olejnik Judith , Aguiar-Pulido Vanessa , Mühlberger Elke , Kanadia Rahul N 
Published: January 2024

AbstractMinor intron–containing genes (MIGs) account for &lt;2% of all human protein–coding genes and are uniquely dependent on the minor spliceosome for proper excision. Despite their low numbers, we surprisingly found a significant enrichment of MIG-encoded proteins (MIG-Ps) in protein–protein interactomes and host factors of positive-sense RNA viruses, including SARS-CoV-1, SARS-CoV-2, MERS coronavirus, and Zika virus. Similarly, we observed a significant enrichment of MIG-Ps in the interactomes and sets of host factors of negative-sense RNA viruses such as Ebola virus, influenza A virus, and the retrovirus HIV-1. We also found an enrichment of MIG-Ps in double-stranded DNA viruses such as Epstein–Barr virus, human papillomavirus, and herpes simplex viruses. In general, MIG-Ps were highly connected and placed in central positions in a network of human–host protein interactions. Moreover, MIG-Ps that interact with viral proteins were enriched with essential genes. We also provide evidence that viral proteins interact with ancestral MIGs that date back to unicellular organisms and are mainly involved in basic cellular functions such as cell cycle, cell division, and signal transduction. Our results suggest that MIG-Ps form a stable, evolutionarily conserved backbone that viruses putatively tap to invade and propagate in human host cells.