bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study supports for rural mature-aged university health students: a Stakian multicase study
Authors: Quilliam Claire , Crawford Nicole , McKinstry Carol , Buccheri Alison , Brito Sara 
Published: February 2024

Abstract
Background
The participation and success of university health students in rural areas is critical in addressing the maldistribution of the rural health workforces internationally. Particular attention to the experiences of mature-aged health students is needed to build a sustainable rural health workforce, given the higher proportions of mature-aged university students in rural, regional and remote areas compared with metropolitan areas and rural mature-aged students wanting to stay in their communities. However, little is known about the kinds of supports rural mature-aged students require to succeed with their studies.

Methods
Drawing on rural standpoint theory and using structural inequality as a retention lens, we explored the current and potential supports that rural mature-aged nursing and allied health students require to successfully participate and complete their pre-professional university course. A Stakian multicase study was undertaken with cases at three rural university campuses in Australia. The data collection was primarily qualitative, with semi-structured interviews, campus surveys and focus groups involving 36 participants (including students, academic and professional staff, and placement supervisors).

Results
This study found supports were provided formally and informally by the university, by the community and manifested by students. Several support gaps as well as potential supports to alleviate them were identified. These include formally acknowledging the mature-aged cohort and their diverse experiences and non-university commitments; fostering connections between mature-aged students; making university affordable; preparing mature-aged students for university; adapting course content and delivery; and restructuring placements for mature-aged students.

Conclusions
We argue that rural mature-aged nursing and allied health students require supports that are age-specific, appropriate to the community context, and harness existing relational processes of rural university campus activity. Rural university campuses need to involve rural mature-aged students and other stakeholders relevant to each context in the process of identifying and implementing student supports for this cohort.
Development of an UPLC-MS/MS method for quantitative analysis of abexinostat levels in rat plasma and application of pharmacokinetics
Authors: Yu Yige , Hu Jinyu , Chen Xiaohai , Wu Hua-lu , Wang Anzhou , Tang Congrong 
Published: February 2024

AbstractBroad-spectrum histone deacetylase inhibitors (HDACi) have excellent anti-tumor effects, such as abexinostat, which was a novel oral HDACi that was widely used in clinical treatment. The purpose of this study was to establish a rapid and reliable method for the detection of abexinostat concentrations in rat plasma using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The mobile phase we used was acetonitrile and 0.1% formic acid, and the internal standard (IS) was givinostat. Selective reaction monitoring (SRM) was used for detection with ion transitions at m/z 397.93 → 200.19 for abexinostat and m/z 422.01 → 186.11 for givinostat, respectively. The intra-day and inter-day precision of abexinostat were less than 11.5% and the intra-day and inter-day accuracy ranged from − 10.7% to 9.7% using this method. During the analysis process, the stability of the test sample was reliable. In addition, the recovery and matrix effects of this method were within acceptable limits. Finally, the method presented in this paper enabled accurate and quick determination of abexinostat levels in rat plasma from the pharmacokinetic study following gavage at a dose of 8.0 mg/kg abexinostat.
Scenery deconstruction: a new approach to understanding the historical characteristics of Nanjing cultural landscape
Authors: Zhang Wenzheng , Wang Yiwei , Fu Lin , Hu Yike 
Published: February 2024

Abstract
The “Eight Scenic Views Paintings” represent crucial visual materials for investigating the history of cultural landscapes. However, traditional methods of interpreting materials struggle to discern the inherent connections between different landscape elements. This study proposes an approach for deconstructing historical images, taking the example of the Forty Scenic Views in the Late Ming Dynasty in Nanjing, China. To explore the co-occurrence structure, hierarchical clustering, and correlation features among various elements, various digital humanities quantification methods were applied, including spatial analysis of ArcGIS, co-occurrence and clustering of KH Coder, and correlation analysis of SPSS. This study reveals the characteristics of the landscape construction of Nanjing in the Late Ming: natural landscape as the foundation, artificial landscape as the core, and advocating tradition as the fashion. It also uncovers the landscape order: mountains, waters, and scenic views interweaved and coexisted, as well as nature and culture intertwined and clustered. In addition, multiple information graphs of the subordinate and co-occurrence relationships of 20 landscape elements were constructed, 5 landscape paradigms were extracted, and 36 pairs of related relationships were discovered, deepening the historical understanding of the urban landscape construction of Nanjing in the Late Ming. This paper puts forward the idea of analyzing historical images by digital method, which provides some essential and detailed historical basis for explaining the value of cultural landscape heritage and shaping contemporary urban landscape.
The relationship between food habits and physical activity and the IQ of primary school children
Authors: Khadem Alireza , Nadery Maryam , Noori Sahar , Ghaffarian-Ensaf Rasool , Djazayery Abolghassem , Movahedi Ariyo 
Published: February 2024

Abstract
Background
Children's intelligence quotient (IQ) is influenced by various environmental and genetic variables. The current study aimed to determine how children's dietary choices and physical activity levels correlated with their IQ.

Methods
A total of 190 students (111 girls and 79 boys) between the ages of 8 and 10 were chosen randomly for this cross-sectional research. For all children, questionnaires were utilized to gather information on their anthropometry, socio-economic position, food habits, and 24-h memory. Children's physical activity questionnaire (CPAQ) was also used to gauge their level of physical activity. Raven's color progressive intelligence test was also used to gauge children's IQ. All the questions may be filled out online with the assistance of parents. SPSS software was used to gather and evaluate the generated data.

Results
Of 190 respondents, 79 (41.6%) are males, and 111 (58.4%) are girls. The results of the study showed that, a positive correlation between children's IQ and physical activity (P = 0.017, r = 0.17), if this relationship was not seen by gender. In addition, a positive correlation was observed between the IQ and food habits scores in all children (P = 0.001, r = 0.24), as well as by gender, that is, male (P = 0.04, r = 0.23) and female (P = 0.006, r = 0.26), which indicates that children with better food habits were associated with higher IQ.

Conclusion
It was shown that elementary school children's IQ, food habits, and degree of physical activity are all positively correlated.
Arching mechanism for large span flexible culverts with shallow soil covers
Authors: Soliman Nashwa Nabil , Akl Sherif Adel Yahia , Rahman Ahmed Hosny Abdel , Mourad Sherif Ahmed 
Published: February 2024

AbstractSoil-steel composite bridges (SSCBs) use the surrounding soil and the culvert’s flexible corrugated steel thin plates to support vertical loads above the culvert. Existing codes use empirical equations based on field measurements and full-scale tests for small and ordinary span SSCBs to estimate the arching process and how it distributes vertical stresses on the culvert walls. The empirical equations then compute the design straining actions. Recent developments in construction technology and urbanization have led to a significant increase in typical spans of SSCBs. This paper investigates large span SSCBs and the associated induced arching action using three-dimensional finite element analysis (FEA). The study compares the FEA findings of straining actions for large span SSCB case studies to the calculations of valid design codes. The comparison demonstrates that existing codes fail to predict the real arching mechanism and, consequently, the resulting straining actions. In addition, the FEA results illustrate how the arching mechanism varies as the span changes. Arching action is typically positive for relatively small spans but becomes negative as the span increases. Finally, results prove that current codes cannot accurately predict real arching, leading to inappropriate design straining actions. For large span SSCBs, these codes require modifications for the arching factors and the profile aspect ratio factors.
Single Versus Fractionated Gamma Knife Radiosurgery for Nonfunctioning Pituitary Adenomas Close to the Optic Pathway: A Multicenter Propensity Score Matched Study
Authors: Albano Luigi , Losa Marco , Barzaghi Lina Raffaella , Barrile Elena , Bindal Shray K. , Wei Zhishuo , Pompeo Edoardo , Villanacci Federico , Del Vecchio Antonella , Flickinger John C. , Niranjan Ajay , Mortini Pietro , Lunsford L. Dade 
Published: February 2024

BACKGROUND AND OBJECTIVES:
Gamma Knife radiosurgery (GKRS), typically administered in a single session (S-GKRS), is an effective treatment for nonfunctioning pituitary adenoma (NFPA). For lesions close to the optic pathway, the use of hypofractionated radiosurgery is growing. This study seeks to compare the results of S-GKRS vs fractionated-GKRS (F-GKRS) for NFPAs adjacent to the optic pathway.

METHODS:
Two cohorts of patients with residual or recurrent NFPAs in contact to the optic pathway were retrospectively included in this study: (1) a group of patients who underwent a 3-day course of F-GKRS in Europe and (2) a group of patients treated with S-GKRS in the United States. A propensity score matching (ratio 1:1) was carried out to obtain and compare 2 homogeneous groups of patients with NFPA.

RESULTS:
A total of 84 patients were included for analysis (42 in the S-GKRS cohort and 42 in the F-GKRS group). The 2 cohorts did not differ for age, sex, number of previous surgical procedure, tumor volume, and follow-up. The mean follow-up was 60.2 ± 37.0 months and 62.4 ± 37.4 months for F-GKRS and S-GKRS cohort, respectively (P = .38). The overall tumor control at last follow-up was achieved in 95.2% and 92.9% of patients in F-GKRS and S-GKRS, respectively (P = .64). The 1-year, 3-year, 5-year, and 7-year progression-free survival rate after F-GKRS was 100%, 97.1%, 97.1%, and 91%, respectively. In the S-GKRS sample, progression-free survival rates were 100%, 100%, 92.5%, and 92.5% at 1, 3, 5, and 7 years after treatment, respectively. Two patients (4.7%) from the F-GKRS cohort and 2 (4.7%) from the S-GKRS cohort sustained visual worsening after radiosurgery (P = 1.0).

CONCLUSION:
In the management of NFPAs adjacent to the optic pathway both F-GKRS and S-GKRS had comparable outcomes and risks at 7 years. Future prospective studies including larger cohorts with longer follow-up are needed to confirm our results.
Vasohibin-1 Expression Can Predict Pathological Complete Remission of Advanced Bladder Cancer with Neoadjuvant Chemotherapy
Authors: Omura Minami , Kosaka Takeo , Kobayashi Hiroaki , Shigeta Keisuke , Matsumoto Kazuhiro , Hara Satoshi , Kikuchi Eiji , Mikami Shuji , Saya Hideyuki , Sato Yasufumi , Oya Mototsugu 
Published: February 2024

Abstract
Background and purpose
Neoadjuvant chemotherapy (NAC) is a well-established standard practice in invasive bladder cancer (BCa), however patient selection remains challenging. High expression of vasohibin-1 (VASH1), an endogenous regulator of angiogenesis, has been reported in high-grade and advanced BCa; however, its prognostic value for chemotherapy outcomes remains unexplored. In this study, we sought to identify biomarkers of chemotherapy response focusing on the relationship between angiogenesis and tissue hypoxia.

Methods
Forty Japanese patients with BCa who underwent NAC and radical cystectomy were included in the present analysis. We compared the immunohistochemical expression of CD34, VASH1, and carbonic anhydrase 9 (CA9) between patients who achieved tumor clearance at operation (ypT0) and those with residual disease after cystectomy.

Results
There were 19 patients in the ypT0 group, while the remaining 21 patients had residual tumors at operation. Patients in the ypT0 group had high microvessel density (p = 0.031), high VASH1 density (p < 0.001), and stronger CA9 staining (p = 0.046) than their counterparts. Multivariate analysis identified microvessel and VASH1 density as independent predictive factors for pathological ypT0 disease (p = 0.043 and 0.002, respectively). The 5-year recurrence-free survival rate was higher in the high VASH1 density group than in the low VASH1 density group (66.3% vs. 33.3%, p = 0.036).

Conclusion
VASH1 density is a potential therapeutic biomarker for chemotherapy response in BCa.
Women's experiences of assessment for urinary incontinence: a qualitative study
Authors: Mjelde Lotte Miriam Eri , Litherland Anne Torine , Beisland Elisabeth Grov 
Published: February 2024

Background: One in four women experience urinary incontinence. A woman's medical history, a physical examination and certain tests can guide specialists in diagnosing and offering treatment. Despite the high prevalence, little is known about women's experience of urinary incontinence assessment. Aim: To explore the experience of a group of women undergoing an assessment for urinary incontinence. Methods: Individual semi-structured interviews were conducted with 10 women who had been assessed for urinary incontinence. A thematic reflective analysis method was used. Findings: The women experienced a lot of shame and worry related to their urinary incontinence and the assessment. Having a safe relationship with the urotherapist was very important, and being given information about treatment options gave hope for a better life. Conclusion: Urinary incontinence and its assessment are associated with shame and anxiety. A good patient–urotherapist relationship is paramount and learning that treatments are available made women feel more optimistic about the future.
Assessment of the triglyceride glucose index in adult patients with chronic diarrhea and constipation
Authors: Zhu Jing-Yi , Liu Mu-Yun , Sun Chang 
Published: February 2024

BACKGROUND
Accumulating evidence suggests that the gut microbiome is involved in the pathogenesis of insulin resistance (IR). However, the link between two of the most prevalent bowel disorders, chronic diarrhea and constipation, and the triglyceride glucose (TyG) index, a marker of IR, has not yet been investigated.
AIM
To investigate the potential association between TyG and the incidence of chronic diarrhea and constipation.
METHODS
This cross-sectional study enrolled 2400 participants from the National Health and Nutrition Examination Survey database from 2009-2010. TyG was used as an exposure variable, with chronic diarrhea and constipation as determined by the Bristol Stool Form Scale used as the outcome variables. A demographic investigation based on TyG quartile subgroups was performed. The application of multivariate logistic regression models and weighted generalized additive models revealed potential correlations between TyG, chronic diarrhea, and constipation. Subgroup analyses were performed to examine the stability of any potential associations.
RESULTS
In the chosen sample, chronic diarrhea had a prevalence of 8.00%, while chronic constipation had a prevalence of 8.04%. In multiple logistic regression, a more prominent positive association was found between TyG and chronic diarrhea, particularly in model 1 (OR = 1.45; 95%CI: 1.17-1.79, P = 0.0007) and model 2 (OR = 1.40; 95%CI: 1.12-1.76, P = 0.0033). No definite association was observed between the TyG levels and chronic constipation. The weighted generalized additive model findings suggested a more substantial positive association with chronic diarrhea when TyG was less than 9.63 (OR = 1.89; 95%CI: 1.05-3.41, P = 0.0344), and another positive association with chronic constipation when it was greater than 8.2 (OR = 1.74; 95%CI: 1.02-2.95, P = 0.0415). The results of the subgroup analyses further strengthen the extrapolation of these results to a wide range of populations.
CONCLUSION
Higher TyG levels were positively associated with abnormal bowel health.
Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma
Authors: Xing Xiao-Yu , Zhang Wei , Liu Li-Ya , Han Li-Ping 
Published: February 2024

BACKGROUND
Neuroendocrine neoplasms of the female genital tract are rare.
AIM
To enhance our clinical understanding of neuroendocrine carcinoma (NEC) of the ovary.
METHODS
A retrospective review was conducted on 12 patients diagnosed with NEC of the ovary, analyzing clinicopathological characteristics, treatment modalities, and survival status.
RESULTS
The median age at diagnosis was 34.5 years (range: 20 to 62 years). Among the 12 cases, 9 were small cell carcinoma of the ovary and 3 were large cell NEC. Five cases were stage I tumors, one case was stage IV, and six cases were stage III. Eleven patients underwent surgery as part of their treatment. All patients received adjuvant chemotherapy. Among the 12 patients, one patient received radiotherapy, and one patient with a BRCA2 mutation was administered PARP inhibitor maintenance after chemotherapy. The median progression-free survival was 13 months, and the median overall survival was 19.5 months. Four cases remained disease-free, while eight cases experienced tumor recurrence, including three cases that resulted in death due to disease recurrence.
CONCLUSION
NEC of the ovary is a rare condition that is more common in women of childbearing age and is associated with aggressive behavior and poor clinical outcomes. Surgical resection remains the mainstay of treatment, with some patients benefiting from adjuvant chemoradiation therapy.
Management of retroperitoneal high-grade serous carcinoma of unknown origin: A case report
Authors: Hsieh Wen-Lin , Ding Dah-Ching 
Published: February 2024

BACKGROUND
Retroperitoneal high-grade serous carcinoma (HGSC) of unknown origin is a sporadic tumor that can originate from ovarian cancer. Herein, we report the case of a woman with retroperitoneal HGSC of unknown origin and describe how she was diagnosed and treated.
CASE SUMMARY
A 71-year-old female presented with the tumor marker CA125 elevated to 1041.9 U/mL upon a regular health examination. Computed tomography revealed retroperitoneal lymph node enlargement. Subsequently, positron emission tomography scanning revealed lesions with increased F-18 fluorodeoxyglucose uptake at the nodes. As a result, she underwent laparoscopic lymph node resection, and pathology revealed metastatic adenocarcinoma with CK7(+), PAX8(+), WT1(+), PR(-), and p53 mutational loss of expression, indicating that the origin may be from the adnexa. The patient was admitted to our ward and underwent laparoscopic staging; however, the pathological results were negative. Under the suspicion of retroperitoneal HGSC of unknown origin, chemotherapy and targeted therapy were initiated. Tumor marker levels decreased after treatment.
CONCLUSION
We present a case of HGSC of unknown origin managed using retroperitoneal lymphadenectomy, staging surgery, chemotherapy, and targeted therapy.
Molière en costumes (Molière in Costumes), curated by Véronique Meunier-Delissnyder
Authors: Dotlačilová Petra 
Published: February 2024

Review of: Molière en costumes (Molière in Costumes), curated by Véronique Meunier-Delissnyder
Centre national du costume de scène (CNCS) (National Centre for Stage Costume), Moulins, 26 May–6 November 2022
The Impact of Macroeconomic Indicators on Medical Tourism: A Global Perspective
Authors: Geitona Mary , Giannake Georgia , Zavras Dimitris , Latsou Dimitra 
Published: February 2024

Medical tourism is an expanding global phenomenon stimulating economic development driven by a combination of multiple macro and socioeconomic factors. The study aims to investigate whether the development of medical tourism globally is associated with specific macroeconomic indicators. The association of Medical Tourism Index (MTI) is explored with Gross Domestic Product (GDP), healthcare spending and international tourism receipts. A countries’ grouping method and an ordinary least squares (OLS) regression model were used. MTI was used as the outcome variable, while macroeconomic indicators as potential predictors. The grouping of countries showed that European and Asian countries as well as Canada excel high ranking in all indicators. However, the Gulf Cooperation Council countries (GCC) that exhibit high performance in GDP, rank below the MTI average. Caribbean and Latin American countries are ranking high in the MTI but fall below the average in all the indicators. The OLS analysis showed a positive correlation between the score of the MTI and health expenditure and no correlation among MTI, GDP and international tourism receipts, a finding also supported by the grouping analysis. Taking into consideration the similarities and disparities found among countries regarding the macroeconomic indicators mostly impacting medical tourism, it seems that there is a consensus on their relationship but not clearly identified rather due to a variety of social, cultural and ethical factors that dominate in each country. Further research is needed in order to obtain more robust and comparative evidence.
Nitrous oxide abuse direct measurement for diagnosis and follow-up: update on kinetics and impact on metabolic pathways
Authors: Lucas Angèle , Noyce Alastair J. , Gernez Emeline , El Khoury Joe M. , Garcon Guillaume , Cavalier Etienne , Antherieu Sébastien , Grzych Guillaume 
Published: February 2024

Abstract
Recreational use of nitrous oxide (N2O) has become a major health issue worldwide, with a high number of clinical events, especially in neurology and cardiology. It is essential to be able to detect and monitor N2O abuse to provide effective care and follow-up to these patients. Current recommendations for detecting N2O in cases of recreational misuse and consumption markers are lacking. We aimed to update current knowledge through a review of the literature on N2O measurement and kinetics. We reviewed the outcomes of experiments, whether in preclinical models (in vitro or in vivo), or in humans, with the aim to identify biomarkers of intoxication as well as biomarkers of clinical severity, for laboratory use. Because N2O is eliminated 5 min after inhalation, measuring it in exhaled air is of no value. Many studies have found that urine and blood matrices concentrations are connected to ambient concentrations, but there is no similar data for direct exposure. There have been no studies on N2O measurement in direct consumers. Currently, patients actively abusing N2O are monitored using effect biomarkers (biomarkers related to the effects of N2O on metabolism), such as vitamin B12, homocysteine and methylmalonic acid.