bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baby HABIT-ILE intervention: study protocol of a randomised controlled trial in infants aged 6–18 months with unilateral cerebral palsy
Authors: Carton de Tournai Astrid , Herman Enimie , Gathy Estelle , Ebner-Karestinos Daniela , Araneda Rodrigo , Dricot Laurence , Macq Benoît , Vandermeeren Yves , Bleyenheuft Yannick 
Published: February 2024

IntroductionResearch using animal models suggests that intensive motor skill training in infants under 2 years old with cerebral palsy (CP) may significantly reduce, or even prevent, maladaptive neuroplastic changes following brain injury. However, the effects of such interventions to tentatively prevent secondary neurological damages have never been assessed in infants with CP. This study aims to determine the effect of the baby Hand and Arm Bimanual Intensive Therapy Including Lower Extremities (baby HABIT-ILE) in infants with unilateral CP, compared with a control intervention.Methods and analysisThis randomised controlled trial will include 48 infants with unilateral CP aged (corrected if preterm) 6–18 months at the first assessment. They will be paired by age and by aetiology of the CP, and randomised into two groups (immediate and delayed). Assessments will be performed at baseline and at 1 month, 3 months and 6 months after baseline. The immediate group will receive 50 hours of baby HABIT-ILE intervention over 2 weeks, between first and second assessment, while the delayed group will continue their usual activities. This last group will receive baby HABIT-ILE intervention after the 3-month assessment. Primary outcome will be the Mini-Assisting Hand Assessment. Secondary outcomes will include behavioural assessments for gross and fine motricity, visual–cognitive–language abilities as well as MRI and kinematics measures. Moreover, parents will determine and score child-relevant goals and fill out questionnaires of participation, daily activities and mobility.Ethics and disseminationFull ethical approval has been obtained by theComité d’éthique Hospitalo-Facultaire/Université catholique de Louvain, Brussels (2013/01MAR/069 B403201316810g). The recommendations of the ethical board and the Belgian law of 7 May 2004 concerning human experiments will be followed. Parents will sign a written informed consent ahead of participation. Findings will be published in peer-reviewed journals and conference presentations.Trial registration numberNCT04698395. Registered on the International Clinical Trials Registry Platform (ICTRP) on 2 December 2020 and NIH Clinical Trials Registry on 6 January 2021. URL of trial registry record:https://clinicaltrials.gov/ct2/show/NCT04698395?term=bleyenheuft&draw=1&rank=7.
Enhanced impact of psoriasis severity on the treatment demands of patients during the COVID-19 pandemic: a cross-sectional study based on a national psoriasis registry in China
Authors: Yang Zhihui , Jin Yu , Wang Mingyue , Li Ruoyu , Li Wen-Qing , Li Hang 
Published: February 2024

ObjectivesThe personalised treatment demands of patients with psoriasis did not get significant attention during the pandemic lockdown. This study aimed to investigate the treatment demands of patients with psoriasis with different severities, stratified by COVID-19 pandemic conditions.DesignCross-sectional study design.SettingMulticentre study based on a national psoriasis registry in China.ParticipantsA total of 22 425 adult patients with psoriasis were enrolled between August 2020 and September 2021.Primary and secondary outcome measuresThe primary outcomes were patient demands for quick healing of skin lesions and improving mental health, which were collected by questionnaires. Multivariable logistic models were used to examine the impact of disease severity, as measured by Psoriasis Area and Severity Index (PASI), body surface area (BSA) and Investigator’s Global Assessment (IGA), on treatment demands, as stratified by COVID-19 pandemic conditions (lockdown vs non-lockdown).ResultsIncreasing PASI score significantly increased patient demands for rapid healing of skin lesions and improving mental health during non-lockdown periods. The magnitude of both associations further increased during the COVID-19 lockdown from an OR of 1.45 (95% CI 1.27 to 1.65) to 2.19 (95% CI 1.57 to 3.05) and 2.21 (95% CI 2.03 to 2.40) to 2.82 (95% CI 2.24 to 3.55), respectively. The skin lesion healing demand was more triggered by the overall irritation level (measured by IGA, OR 1.64, 95% CI 1.35 to 1.99 during non-lockdown periods vs OR 2.70, 95% CI 1.63 to 4.49 during lockdowns), while the mental health improving demand was more triggered by lesion coverage (measured by BSA, OR 2.01, 95% CI 1.85 to 2.19 vs OR 3.27, 95% CI 2.57 to 4.15).ConclusionsPsoriasis aggravation significantly increased patients’ treatment demands, especially during lockdowns. The used psoriasis severity measures highlighted patients’ treatment demands differently. This suggests more accessible and personalised healthcare for patients with psoriasis should be available during future pandemics.
Development, piloting and evaluation of an app-supported psychosocial prevention intervention to strengthen participation in working life: a study protocol of a mixed-methods approach
Authors: Stephan Johannes , Gehrmann Jan , Stullich Ananda , Hoffmann Laura , Richter Matthias 
Published: February 2024

IntroductionRates of incapacity to work due to mental disorders have increased in many European countries. The consequences of persistent stress can impact individuals’ physical and psychological well-being and gradually develop into chronic stress. Mental disorders or symptoms of burn-out syndrome can have severe consequences. Mental disorders leading to work incapacity significantly burden the health system. Prevention interventions can protect against burn-out, depression, anxiety and other mental health disorders. Digital health is a promising approach to increase the utilisation of effective prevention interventions. This mixed-methods study evaluates a newly developed app-supported psychosocial prevention intervention called ‘RV Fit Mental Health’ to strengthen participation in working life.Methods and analysisThe study uses a three-stage parallel mixed-methods design. This study accompanies the development (stage 1), piloting (stage 2) and evaluation (stage 3) of the new intervention. Within the stages, there is a quantitative as well as a qualitative research strand. Employed persons with an incipient mental disorder will be included. Additionally, experts within the project or connected areas will be included. Quantitative data will be analysed using multifactorial variance analyses in a pre–post design. Qualitative data will be analysed using qualitative content analysis. The study is a comprehensive research approach to investigate the development, piloting and evaluation of an app-supported psychosocial app-based prevention intervention. The rigour of the study will be achieved through data triangulation.Ethics and disseminationAll participants will receive detailed study information and give written informed consent before data collection. Ethical approval was obtained from the Technical University of Munich Ethics Committee. All data collection will follow all legislative rules regarding data protection, also following the Declaration of Helsinki. The study results will be disseminated in peer-reviewed journals and presented at international conferences.Trial registration numbersDRKS00030818 and DRKS00033080.
Patient experiences with patient-led, home-based follow-up after curative treatment for colorectal cancer: a qualitative study
Authors: Swartjes Hidde , Aarts Charlotte J H , Deuning-Smit Esther , Vromen Heleen A B , de Wilt J H W (Hans) , Vos Julien A M , Custers José A E 
Published: February 2024

ObjectivesThe number of patients with colorectal cancer (CRC) in need of oncological follow-up is growing. As a response, patient-led, home-based follow-up (PHFU) was developed, implemented and assessed. The aim of this study was to investigate how patients experienced PHFU.DesignA qualitative study with individual semistructured interviews. Interviews were transcribed verbatim, and thematically analysed through an inductive, double-coding approach.SettingA university medical centre in the Netherlands.Participants12 curatively treated patients with CRC who received PHFU were included after purposive sampling.ResultsOverall, participants (N=12) were satisfied with PHFU. The time and cost-saving aspects for patient and hospital were evidently valued. PHFU was experienced as a shared effort, but patients felt like the primary responsibility remained in the hospital. Patients mentioned a decreased personal interaction with their healthcare provider (HCP) and felt a higher threshold to ask for help. However, all major questions were still addressed. Patients felt sufficiently competent to interpret their individual test results but experienced difficulty in interpreting repeated increases in carcinoembryonic antigen levels within the normal range. Educational status, age and a complicated disease course were seen as factors limiting the applicability of PHFU, and it was expressed that PHFU should be offered as an alternative instead of a novel standard of care.ConclusionsAccording to patients, PHFU has great potential. However, PHFU may not be suitable for every CRC patient, and factors such as educational status, age and disease course should be taken into consideration. Patient and HCP have a shared responsibility to help successfully organise PHFU in practice.
Study protocol for FASTRAK: a randomised controlled trial evaluating the cost impact and effectiveness of FAST-MRI for HCC suRveillance in pAtients with high risK of liver cancer
Authors: Nahon Pierre , Ronot Maxime , Sutter Olivier , Natella Pierre-André , Baloul Samia , Durand-Zaleski Isabelle , Audureau Etienne 
Published: February 2024

IntroductionThe surveillance of hepatocellular carcinoma (HCC) using semi-annual liver ultrasound (US) is justified in patients with cirrhosis. In this context, US has a low sensitivity (<30%) for the detection of HCC at the very early stage (ie, Barcelona clinic liver cancer (BCLC) 0, uninodular tumour <2 cm). The sensitivity of abbreviated liver MRI (AMRI) is reported to exceed 80%, but its use is hampered by costs and availability. Our hypothesis is that AMRI used as a screening examination in patients at high risk of HCC (>3% per year) could increase the rates of patients with a tumour detected at an early stage accessible to curative-intent treatment, and demonstrate its cost-effectiveness in this population.Methods and analysisThe FASTRAK trial is a multicentre, randomised controlled trial with two parallel arms, aiming for superiority and conducted on patients at high risk for HCC (yearly HCC incidence >3%). Randomisation will be conducted on an individual basis with a centralised approach and stratification by centre. After inclusion in the trial, each patient will be randomly assigned to the experimental group (semi-annual US and AMRI) or the control group (semi-annual US alone). The main objective is to assess the cost/quality-adjusted life year and cost/patient detected with a BCLC 0 HCC in both arms. A total of 944 patients will be recruited in 37 tertiary French centres during a 36-month period and will be followed-up during 36 months.Ethics and disseminationThe FASTRAK trial received ethical approval on 4 April 2022. Results will be disseminated via publication in peer-reviewed journals as well as presentation at international conferences.Trial registration numberClinical trial number (ClinicaTrials.gov)NCT05095714.
How much does government’s short-term response matter for explaining cross-country variation in COVID-19 infection outcomes? A regression-based relative importance analysis of 84 countries
Authors: Liu Gordon G , Peng Xiaoyun , Yang Hanmo , Yi Junjian 
Published: February 2024

ObjectiveWe study the predetermined characteristics of countries in addition to their government non-pharmaceutical interventions (NPIs) to shed light on the correlates of the variation in COVID-19 infection outcomes across countries.Methods and analysisWe conduct a systematic investigation of the validity of government responses in 84 countries by gradually adding the predetermined cultural, natural and socioeconomic factors of each country using a fixed-effect model and daily panel data. A relative importance analysis is conducted to isolate the contribution of each variable to the R2of the model.ResultsGovernment NPIs are effective in containing the virus spread and explain approximately 9% of the variations in the pandemic outcomes. COVID-19 is more prevalent in countries that are more individual-oriented or with a higher gross domestic product (GDP) per capita, while a country’s government expenditure on health as a proportion of GDP and median age are negatively associated with the infection outcome. The SARS-CoV-2 lifecycle and the impacts of other unobserved factors together explain more than half of the variation in the prevalence of COVID-19 across countries. The degree of individualism explains 9.30% of the variation, and the explanatory power of the other socioeconomic factors is less than 4% each.ConclusionThe COVID-19 infection outcomes are correlated with multivariate factors, ranging from state NPIs, culture-influenced human behaviours, geographical conditions and socioeconomic conditions. As expected, the stronger or faster are the government responses, the lower is the level of infections. In the meantime, many other factors underpin a major part of the variation in the control of COVID-19. As such, from a scientific perspective, it is important that country-specific conditions are taken into account when evaluating the impact of NPIs in order to conduct more cost-effective policy interventions.
Missingness matters: a secondary analysis of thromboelastography measurements from a recent prehospital randomized tranexamic acid clinical trial
Authors: Donohue Jack K , Iyanna Nidhi , Lorence John M , Brown Joshua B , Guyette Frances X , Eastridge Brian J , Nirula Raminder , Vercruysse Gary A , O'Keeffe Terence , Joseph Bellal , Neal Matthew D , Sperry Jason L 
Published: February 2024

BackgroundTranexamic acid (TXA) has been hypothesized to mitigate coagulopathy in patients after traumatic injury. Despite previous prehospital clinical trials demonstrating a TXA survival benefit, none have demonstrated correlated changes in thromboelastography (TEG) parameters. We sought to analyze if missing TEG data contributed to this paucity of findings.MethodsWe performed a secondary analysis of the Study of Tranexamic Acid During Air Medical and Ground Prehospital Transport Trial. We compared patients that received TEG (YES-TEG) and patients unable to be sampled (NO-TEG) to analyze subgroups in which to investigate TEG differences. TEG parameter differences across TXA intervention arms were assessed within subgroups disproportionately present in the NO-TEG relative to the YES-TEG cohort. Generalized linear models controlling for potential confounders were applied to findings with p<0.10 on univariate analysis.ResultsNO-TEG patients had lower prehospital systolic blood pressure (SBP) (100 (78, 140) vs 125 (88, 147), p<0.01), lower prehospital Glascow Coma Score (14 (3, 15) vs 15 (12, 15), p<0.01), greater rates of prehospital intubation (39.4% vs 24.4%, p<0.01) and greater mortality at 30 days (36.4% vs 6.8%, p<0.01). NO-TEG patients had a greater international normalized ratio relative to the YES-TEG subgroup (1.2 (1.1, 1.5) vs 1.1 (1.0, 1.2), p=0.04). Within a severe prehospital shock cohort (SBP<70), TXA was associated with a significant decrease in clot lysis at 30 min on multivariate analysis (β=−27.6, 95% CI (−51.3 to –3.9), p=0.02).ConclusionsMissing data, due to the logistical challenges of sampling certain severely injured patients, may be associated with a lack of TEG parameter changes on TXA administration in the primary analysis. Previous demonstration of TXA’s survival benefit in patients with severe prehospital shock in tandem with the current findings supports the notion that TXA acts at least partially by improving clot integrity.Level of evidenceLevel II.
Reinvestigation of $$^{91}$$Sr and $$^{95}$$Y atomic masses using the JYFLTRAP Penning trap
Authors: Jaries A. , Stryjczyk M. , Kankainen A. , Eronen T. , Ge Z. , Mougeot M. , Raggio A. , Ruotsalainen J. 
Published: February 2024

AbstractWe report on the precise mass measurements of the $$^{91}$$

91

Sr and $$^{95}$$

95

Y isotopes performed using the JYFLTRAP double Penning trap mass spectrometer. The mass-excess values from this work, $${\textrm{ME}(^{91}\textrm{Sr}) = -83645.5(13)}$$

ME

(
91

Sr
)

=
-
83645.5

(
13
)

keV and $${\textrm{ME}(^{95}\textrm{Y}) = -81226.4(10)}$$

ME

(
95

Y
)

=
-
81226.4

(
10
)

keV, deviate by 6.5(52) keV and $$-18(7)$$

-
18
(
7
)

keV from the Atomic Mass Evaluation 2020 (AME20). In the case of $$^{91}$$

91

Sr the new result disagrees with the ISOLTRAP value, while for $$^{95}$$

95

Y, it agrees with the older JYFLTRAP value.
The effectiveness of case method in developing intrapreneurship among business students
Authors: Tambunan Khairuddin Ependi , Hasibuan Ali Fikri , Prayogo Rangga Restu , Dongoran Faisal Rahman , Syah Dedy Husrizal , Sagala Gaffar Hafiz 
Published: February 2024

Intrapreneurship skill has considered as the alternative learning outcomes of entrepreneurship education. However, entrepreneurship teachers need a complex learning program to develop intrapreneurship among business students. At the same time, The Ministry of Education and Culture of The Republic of Indonesia recommends university teachers implement case methods to deliver complex learning environments and build critical skills among students. Therefore, this study aims to i) examine the effect of micro small medium enterprise (MSME) cases on the intrapreneurship of business students, ii) investigate the influence of MSME cases on flow experience in entrepreneurship education and iii) investigate the effect of flow experience during entrepreneurship education on intrapreneurship skill. We used field experiments on entrepreneurship and digital business student in business development courses. The result indicates that the case method effectively developed student intrapreneurship skill and flow experience during the course positively impacting student intrapreneurship skill.
Functional recovery in older adults with schizophrenia: A national interRAI study
Authors: Barak Yoram , Sajjadi S. Fatemeh , Hobbs Linda , Patterson Tess 
Published: February 2024

Background: The concept of recovery for people with schizophrenia (PwS) is still a matter of debate. Growing numbers of PwS living to older age calls for examination of their disease trajectories with a focus on recovery. Aim: To compare two groups of PwS (good wellbeing; poor wellbeing) on several psychosocial variables associated with social wellbeing to identify interventions that support functional recovery. Method: Data was drawn from participants from across New Zealand (NZ), who had received a formal diagnosis of Schizophrenia; were living independently in the community, and who had undergone their first International Resident Assessment Instrument (interRAI) assessment from 2012 to 2022. We compared two groups of PwS (good social wellbeing; poor social wellbeing) examining associations with demographic and psychosocial variables. Results: We compared interRAI assessments for: ‘poor psychosocial wellbeing’ ( n = 1,378; 67%; 56% female; 70.5% 65 years and over; 36.1% never married); and ‘good psychosocial wellbeing’ ( n = 693; 33%; 61.1% female; 78.1% 65 years and over; 29.8% never married; n = 549 did not have sufficient social wellbeing data to be included). We found significant associations between social wellbeing and depression, disruptive behaviour, decision making, self-expression, understanding verbal information, activity level, self-reported health and medication adherence. Logistical regression showed depression (β = .84, p < .001, Wald = 51.01, Exp( B) = 2.31) and mild disruptive behaviour (β = .63, p = .002, Wald = 9.26, Exp( B) = 0.53) were the only predictors of poor social wellbeing. Those who reported some degree of depressive symptoms were 2.31 (CI [1.84, 2.91]) more likely to be in the poor social wellbeing group. Conclusions: A significant minority (33.5%) of older PwS enjoy positive social wellbeing. Several psychosocial variables are associated with wellbeing. By addressing the comorbidity of depressive symptoms, we may be able to improve wellbeing for older PwS.
Feasibility of OT-Parentship: An intervention for parents of adolescents with autism
Authors: Wachspress Batel , Berger Itai , Maeir Adina , Mazor-Karsenty Tal 
Published: February 2024

Introduction: Parents of individuals with autism face various difficulties, among which are decreased resilience and heightened stress. OT-Parentship is an intervention for parents of adolescents with autism that aims to promote parental resilience and enhance adolescents’ participation in daily life. This study examines OT-Parentship’s feasibility and explores the improvement of parental resilience and child and parent occupational performance following intervention. Methods: A mixed methods pre-post and follow up study. Fourteen parents (six mothers and four couples) of adolescents with autism participated in a series of 13 individual weekly sessions of 90 minutes each. Study results were analyzed before, after, and 3 months post intervention. Results: All parents completed treatment, with 100% adherence to sessions. Therapist’s treatment fidelity was estimated at 95–97% and parent homework completion was 85%. Preliminary efficacy findings show significant improvement in mothers’ and adolescents’ occupational performance and improvement in maternal resiliency. Conclusion: Research results support the feasibility of the OT-Parentship as a family centered, strength-based, intervention program that leads to improvements in adolescent participation and parental resilience.
The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project
Authors: Carucci Sara , Zuddas Alessandro , Lampis Angelico , Man Kenneth K. C. , Balia Carla , Buitelaar Jan , Danckaerts Marina , Dittmann Ralf W. , Donno Federica , Falissard Bruno , Gagliano Antonella , Garas Peter , Häge Alexander , Hollis Chris , Inglis Sarah K. , Konrad Kerstin , Kovshoff Hanna , Liddle Elizabeth , McCarthy Suzanne , Neubert Antje , Nagy Peter , Rosenthal Eric , Sonuga-Barke Edmund J. S. , Wong Ian C. K. , Banaschewski Tobias , Coghill David 
Published: February 2024

Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age. Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age. Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable. Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.