bluuebunny/crossref_metadata_2025_split huggingface dataset:
The asymptotic tails of limit distributions of continuous-time Markov chains
Authors: Xu Chuang , Hansen Mads Christian , Wiuf Carsten 
Published: October 2023

AbstractThis paper investigates tail asymptotics of stationary distributions and quasi-stationary distributions (QSDs) of continuous-time Markov chains on subsets of the non-negative integers. Based on the so-called flux-balance equation, we establish identities for stationary measures and QSDs, which we use to derive tail asymptotics. In particular, for continuous-time Markov chains with asymptotic power law transition rates, tail asymptotics for stationary distributions and QSDs are classified into three types using three easily computable parameters: (i) super-exponential distributions, (ii) exponential-tailed distributions, and (iii) sub-exponential distributions. Our approach to establish tail asymptotics of stationary distributions is different from the classical semimartingale approach, and we do not impose ergodicity or moment bound conditions. In particular, the results also hold for explosive Markov chains, for which multiple stationary distributions may exist. Furthermore, our results on tail asymptotics of QSDs seem new. We apply our results to biochemical reaction networks, a general single-cell stochastic gene expression model, an extended class of branching processes, and stochastic population processes with bursty reproduction, none of which are birth–death processes. Our approach, together with the identities, easily extends to discrete-time Markov chains.
Antimicrobial stewardship for nurse practitioners and physician assistants: enhancing patient safety through education
Authors: Parzen-Johnson Simon , Toia Jacquie , Sun Shan , Patel Sameer J. 
Published: October 2023

Abstract

Background:
As nurse practitioners and physician assistants (APPs) become more prevalent in delivering pediatric care, their involvement in antimicrobial stewardship efforts increases in importance. This project aimed to create and assess the efficacy of a problem-based learning (PBL) approach to teaching APPs antimicrobial stewardship principles.

Methods:
A PBL education initiative was developed after communication with local APP leadership and focus group feedback. It was offered to all APPs associated with Lurie Children’s Hospital of Chicago. Participants completed a survey which assessed opinions on antimicrobial stewardship and included knowledge-based questions focused on antimicrobial stewardship. Prescriptions for skin and soft tissue infections associated with APPs were recorded via chart review before and after the education campaign.

Results:
Eighty APPs participated in the initial survey and teaching initiative with 44 filling out the 2-week follow-up and 29 filling out the 6-month follow-up. Subjective opinions of antimicrobial stewardship and comfort with basic principles of AS increased from pre-intervention. Correct responses to knowledge-based assessments increased from baseline after 2-week follow-up (p < 0.01) and were maintained at the 6-month follow-up (p = 0.03). Simple skin and soft tissue infection prescriptions for clindamycin went from 44.4% pre-intervention to 26.5% (p = 0.2) post-intervention.

Conclusions:
A PBL approach for APP education on antimicrobial stewardship can be effective in increasing knowledge and comfort with principles of antimicrobial stewardship. These changes are maintained in long-term follow-up. Changes in prescribing habits showed a strong trend towards recommended empiric therapy choice. Institutions should develop similar education campaigns for APPs.
Vulnerability Theory as a Paradigm Shift in International Investment Law: Reimagining the Role of the State
Authors: Küçüksu Aysel , Ünüvar Güneş 
Published: October 2023

Abstract
This article argues for a fundamental raison d’être reconceptualization of international investment law (IIL) through Martha Fineman’s ‘vulnerability theory’. The theory helps identify the structural sources of IIL’s shortcomings, whilst philosophically challenging the one-sided view that foreign investors are entitled to protections, but are free from obligations vis-à-vis the communities affected by their undertakings. Emphasizing the productive power of the state to take positive action that acknowledges ordinary citizens’ embeddedness within, and dependence upon, surrounding structures, the vulnerability theory challenges the hegemonic perception of the state as a source of danger – a view which has hitherto undermined both the potency and the enforceability of investor obligations. Used as a heuristic device in studying both IIL’s existing structures and the potential avenues for reimagining it, Fineman’s theory not only shines a novel light on the foundational premises of IIL, but also grants theoretical traction to existing ideas about improving the system.
Pandemic and Emergency Manufacturing Innovation: A Scientometric Analysis Using CiteSpace
Authors: Xie Tian , Wu Juan , Chen Wei-Fan , Wei Yao-Yao , Chen Krista 
Published: October 2023

Abstract

Objective:
Major epidemics have had a huge impact on the manufacturing industry. This study aimed to explore knowledge innovation in the field of emergency manufacturing during pandemics with a systematic quantitative analysis.

Methods:
Based on the Web of Science (WOS) Core Collection, the bibliometric method and the CiteSpace tool were used.

Results:
A total of 286 literature were obtained from the WOS database. During coronavirus disease (COVID-19), there was a surge in the number of publications. A new field of research on pandemic-triggered emergency manufacturing is gradually forming with accumulated research output. The analysis of the document co-citation showed how the research on pandemic situations and viruses brought emergency manufacturing into the research scope of scholars, and what attempts were made by the original scholars. Pandemic-triggered research hotspots and research trends in the post-pandemic era mainly boiled down to 3 aspects: technological innovation, material innovation, and management innovation in the field of emergency manufacturing.

Conclusions:
COVID-19 strengthened academic exchange and cooperation and promotes knowledge output in this field. This study provides an in-depth perspective for emergency manufacturing research and helps researchers realize the panorama of this field and establish future research directions.
Understanding the Policy Integration Challenges of Sustainable Urban Mobility in the Context of Rapid Decarbonisation
Authors: Colombo Carlo Maria , Dijk Marc 
Published: October 2023

AbstractGiven the state of the climate emergency, European Union (EU) cities must find innovative ways to achieve a sustainable and decarbonised urban mobility trajectory. This requires integrated and cross-sectoral approaches that enable all sectors influencing such mobility to contribute to this goal. Building on the concept of the climate-connected city and drawing on an extensive empirical investigation of two Dutch cities (Rotterdam and Maastricht), this study reflects on how decarbonisation targets are integrated with other sustainability objectives across all policies and levels involved in reconfiguring mobility towards an environmentally sustainable model. The study finds that spatial development tools and processes, in combination with regulatory instruments imposing strict limits on emissions, can strengthen cross-sectoral support for the behavioural changes needed to decarbonise urban mobility. However, this integrative dynamic may be countered by local economic actors and by national and EU economic and fiscal instruments, whose narrow focus on reducing vehicle emissions and expanding road capacity forces cities to dilute their sustainable mobility policies. This suggests that in order to accelerate the decarbonisation of urban mobility, these instruments should be aligned with a broader set of sustainability goals and solutions and be combined with greater attention being given to the urban dimension into national and European transport policies.
Might the bioethical principle of individual decisional autonomy have a politically liberalizing effect on soft authoritarian communities?
Authors: Gregg Benjamin 
Published: October 2023

AbstractAccording to the bioethical principle of individual decisional autonomy, the patient has a right of informed consent to any medical or experimental procedure. The principle is politically liberal by advocating significant individual freedom as guaranteed by law and secured by civil liberties. When practiced in illiberal communities, might it have a political liberalizing effect? I respond first by analyzing cross-national norms of individual decisional autonomy to identify tensions with illiberal community; second, by examining examining Singapore in a single case study to show that liberal bioethics does not promote political liberalization; and third, by showing that the possibility of practicing liberal bioethics in research, clinically as well as in education, does not require a democratic order, and that liberal bioethics is unlikely to encourage the liberalization of illiberal political communities. Hence, it may never contribute to the development of globally effective cross-national norms for the legal regulation of bioethical research and clinical practice. Fourth, to bolster this analysis, I anticipate several possible objections to various of its aspects.
TRIPLE-PRODUCT-FREE SETS
Authors: AGIGOR-MIKE PRECIOUS U. , HART SARAH B. , OBI MARTIN C. 
Published: October 2023

AbstractIn this paper, we study triple-product-free sets, which are analogous to the widely studied concept of product-free sets. A nonempty subset S of a group G is triple-product-free if
$abc \notin S$
for all
$a, b, c \in S$
. If S is triple-product-free and is not a proper subset of any other triple-product-free set, we say that S is locally maximal. We classify all groups containing a locally maximal triple-product-free set of size 1. We then derive necessary and sufficient conditions for a subset of a group to be locally maximal triple-product-free, and conclude with some observations and comparisons with the situation for standard product-free sets.
ON EXTERIOR POWERS OF REFLECTION REPRESENTATIONS
Authors: HU HONGSHENG 
Published: October 2023

AbstractIn 1968, Steinberg [Endomorphisms of Linear Algebraic Groups, Memoirs of the American Mathematical Society, 80 (American Mathematical Society, Providence, RI, 1968)] proved a theorem stating that the exterior powers of an irreducible reflection representation of a Euclidean reflection group are again irreducible and pairwise nonisomorphic. We extend this result to a more general context where the inner product invariant under the group action may not necessarily exist.
Racial and ethnic disparities in COVID-19 diagnosis and adherence to mitigation behaviours in a national United States older adult sample
Authors: Wong Roger , Lovier Margaret Anne 
Published: October 2023

Abstract
Older adults and people of colour are vulnerable to the COVID-19 pandemic, and mitigation behaviours reduce COVID-19 infection. We examined racial and ethnic differences in COVID-19 diagnosis and adherence to COVID-19 mitigation behaviours among U.S. older adults. Data were retrieved from the National Health and Aging Trends Study, a nationally representative prospective cohort with 3257 U.S. Medicare beneficiaries aged 65+. COVID-19 variables were collected in 2020; all other data in 2019. Odds of COVID-19 diagnosis and adherence to mitigation behaviours (handwashing, masking, social distancing) were analysed using logistic regression. Compared to White older adults, only Hispanic respondents had 2.7 times significantly higher odds of COVID-19 after adjusting for sociodemographics, health, and mitigation behaviours (aOR = 2.71, 95% CI = 1.20-6.12). Black older adults had 7.9 times significantly higher odds of masking (aOR = 7.94, 95% CI = 2.33-27.04) and 2.3 times higher odds of social distancing (aOR = 2.33, 95% CI = 1.28-4.24), after adjusting for sociodemographics and health. Among all racial and ethnic groups, only Hispanic older adults had a significantly elevated COVID-19 diagnosis. Despite higher adherence to COVID-19 mitigation behaviours among racial and ethnic minorities, especially Black older adults, odds of COVID-19 remained elevated. Research is needed to explore potential mechanisms for higher odds of COVID-19 among minority older adults.
Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons
Authors: Santa Cátia , Rodrigues Diana , Coelho Joana F. , Anjo Sandra I. , Mendes Vera M. , Bessa-Neto Diogo , Dunn Michael J. , Cotter David , Baltazar Graça , Monteiro Patrícia , Manadas Bruno 
Published: October 2023

AbstractStriatal dysfunction has been implicated in the pathophysiology of schizophrenia, a disorder characterized by positive symptoms such as hallucinations and delusions. Haloperidol is a typical antipsychotic medication used in the treatment of schizophrenia that is known to antagonize dopamine D2 receptors, which are abundantly expressed in the striatum. However, haloperidol’s delayed therapeutic effect also suggests a mechanism of action that may go beyond the acute blocking of D2 receptors. Here, we performed proteomic analysis of striatum brain tissue and found more than 400 proteins significantly altered after 30 days of chronic haloperidol treatment in mice, namely proteins involved in glutamatergic and GABAergic synaptic transmission. Cell-type specific electrophysiological recordings further revealed that haloperidol not only reduces the excitability of striatal medium spiny neurons expressing dopamine D2 receptors (D2-MSNs) but also affects D1-MSNs by increasing the ratio of inhibitory/excitatory synaptic transmission (I/E ratio) specifically onto D1-MSNs but not D2-MSNs. Therefore, we propose the slow remodeling of D1-MSNs as a mechanism mediating the delayed therapeutic effect of haloperidol over striatum circuits. Understanding how haloperidol exactly contributes to treating schizophrenia symptoms may help to improve therapeutic outcomes and elucidate the molecular underpinnings of this disorder.
Mechanism of the noncatalytic oxidation of soot using in situ transmission electron microscopy
Authors: Gao Ming , Jang Yongjun , Ding Lu , Gao Yunfei , Dai Sheng , Dai Zhenghua , Yu Guangsuo , Yang Wenming , Wang Fuchen 
Published: October 2023

AbstractSoot generation is a major challenge in industries. The elimination of soot is particularly crucial to reduce pollutant emissions and boost carbon conversion. The mechanisms for soot oxidation are complex, with quantified models obtained under in situ conditions still missing. We prepare soot samples via noncatalytic partial oxidation of methane. Various oxidation models are established based on the results of in situ transmission electron microscopy experiments. A quantified maturity parameter is proposed and used to categorize the soot particles according to the nanostructure at various maturity levels, which in turn lead to different oxidation mechanisms. To tackle the challenges in the kinetic analysis of soot aggregates, a simplification model is proposed and soot oxidation rates are quantified. In addition, a special core-shell separation model is revealed through in situ analysis and kinetic studies. In this study, we obtain important quantified models for soot oxidation under in situ conditions.
The global and regional air quality impacts of dietary change
Authors: Springmann Marco , Van Dingenen Rita , Vandyck Toon , Latka Catharina , Witzke Peter , Leip Adrian 
Published: October 2023

AbstractAir pollution increases cardiovascular and respiratory-disease risk, and reduces cognitive and physical performance. Food production, especially of animal products, is a major source of methane and ammonia emissions which contribute to air pollution through the formation of particulate matter and ground-level ozone. Here we show that dietary changes towards more plant-based flexitarian, vegetarian, and vegan diets could lead to meaningful reductions in air pollution with health and economic benefits. Using systems models, we estimated reductions in premature mortality of 108,000-236,000 (3-6%) globally, including 20,000-44,000 (9-21%) in Europe, 14,000-21,000 (12-18%) in North America, and 49,000-121,000 (4-10%) in Eastern Asia. We also estimated greater productivity, increasing economic output by USD 0.6-1.3 trillion (0.5-1.1%). Our findings suggest that incentivising dietary changes towards more plant-based diets could be a valuable mitigation strategy for reducing ambient air pollution and the associated health and economic impacts, especially in regions with intensive agriculture and high population density.
Catalytic enantioselective reductive alkynylation of amides enables one-pot syntheses of pyrrolidine, piperidine and indolizidine alkaloids
Authors: Xu Fang-Fang , Chen Jin-Quan , Shao Dong-Yang , Huang Pei-Qiang 
Published: October 2023

AbstractThe primary objective in synthetic organic chemistry is to develop highly efficient, selective, and versatile synthetic methodologies, which are essential for discovering new drug candidates and agrochemicals. In this study, we present a unified strategy for a one-pot, catalytic enantioselective synthesis of α-alkyl and α,α′-dialkyl pyrrolidine, piperidine, and indolizidine alkaloids using readily available amides and alkynes. This synthesis is enabled by the identification and development of an Ir/Cu/N-PINAP catalyzed highly enantioselective and chemoselective reductive alkynylation of α-unbranched aliphatic amides, which serves as the key reaction. This reaction is combined with Pd-catalyzed tandem reactions in a one-pot approach, enabling the collective, catalytic enantioselective total syntheses of eight alkaloids and an anticancer antipode with 90–98% ee. The methodology’s enantio-divergence is exemplified by the one-step access to either enantiomer of alkaloid bgugaine.
Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy
Authors: Yu Chaojie , Shi Mingyue , He Shaoshuai , Yao Mengmeng , Sun Hong , Yue Zhiwei , Qiu Yuwei , Liu Baijun , Liang Lei , Zhao Zhongming , Yao Fanglian , Zhang Hong , Li Junjie 
Published: October 2023

AbstractWith advances in tissue engineering and bioelectronics, flexible electronic hydrogels that allow conformal tissue integration, online precision diagnosis, and simultaneous tissue regeneration are expected to be the next-generation platform for the treatment of myocardial infarction. Here, we report a functionalized polyaniline-based chronological adhesive hydrogel patch (CAHP) that achieves spatiotemporally selective and conformal embedded integration with a moist and dynamic epicardium surface. Significantly, CAHP has high adhesion toughness, rapid self-healing ability, and enhanced electrochemical performance, facilitating sensitive sensing of cardiac mechanophysiology-mediated microdeformations and simultaneous improvement of myocardial fibrosis-induced electrophysiology. As a result, the flexible CAHP platform monitors diastolic-systolic amplitude and rhythm in the infarcted myocardium online while effectively inhibiting ventricular remodeling, promoting vascular regeneration, and improving electrophysiological function through electrocoupling therapy. Therefore, this diagnostic and therapeutic integration provides a promising monitorable treatment protocol for cardiac disease.
Multiple channelling single-photon emission with scattering holography designed metasurfaces
Authors: Komisar Danylo , Kumar Shailesh , Kan Yinhui , Meng Chao , Kulikova Liudmila F. , Davydov Valery A. , Agafonov Viatcheslav N. , Bozhevolnyi Sergey I. 
Published: October 2023

AbstractChannelling single-photon emission in multiple well-defined directions and simultaneously controlling its polarization characteristics is highly desirable for numerous quantum technology applications. We show that this can be achieved by using quantum emitters (QEs) nonradiatively coupled to surface plasmon polaritons (SPPs), which are scattered into outgoing free-propagating waves by appropriately designed metasurfaces. The QE-coupled metasurface design is based on the scattering holography approach with radially diverging SPPs as reference waves. Using holographic metasurfaces fabricated around nanodiamonds with single Ge vacancy centres, we experimentally demonstrate on-chip integrated efficient generation of two well-collimated single-photon beams propagating along different 15° off-normal directions with orthogonal linear polarizations.
Transferable equivariant graph neural networks for the Hamiltonians of molecules and solids
Authors: Zhong Yang , Yu Hongyu , Su Mao , Gong Xingao , Xiang Hongjun 
Published: October 2023

AbstractThis work presents an E(3) equivariant graph neural network called HamGNN, which can fit the electronic Hamiltonian matrix of molecules and solids by a complete data-driven method. Unlike invariant models that achieve equivariance approximately through data augmentation, HamGNN employs E(3) equivariant convolutions to construct the Hamiltonian matrix, ensuring strict adherence to all equivariant constraints inherent in the physical system. In contrast to previous models with limited transferability, HamGNN demonstrates exceptional accuracy on various datasets, including QM9 molecular datasets, carbon allotropes, silicon allotropes, SiO2 isomers, and BixSey compounds. The trained HamGNN models exhibit accurate predictions of electronic structures for large crystals beyond the training set, including the Moiré twisted bilayer MoS2 and silicon supercells with dislocation defects, showcasing remarkable transferability and generalization capabilities. The HamGNN model, trained on small systems, can serve as an efficient alternative to density functional theory (DFT) for accurately computing the electronic structures of large systems.
Additive manufacturing of metallic glass from powder in space
Authors: Neumann Christian , Thore Johannes , Clozel Mélanie , Günster Jens , Wilbig Janka , Meyer Andreas 
Published: October 2023

AbstractAdditive manufacturing of metals – and in particular building with laser-based powder bed fusion – is highly flexible and allows high-resolution features and feedstock savings. Meanwhile, though space stations in low Earth orbit are established, a set of visits to the Moon have been performed, and humankind can send out rovers to explore Venus and Mars, none of these milestone missions is equipped with technology to manufacture functional metallic parts or tools in space. In order to advance space exploration to long-term missions beyond low Earth orbit, it will be crucial to develop and employ technology for in-space manufacturing (ISM) and in-situ resource utilisation (ISRU). To use the advantages of laser-based powder bed fusion in these endeavours, the challenge of powder handling in microgravity must be met. Here we present a device capable of building parts using metallic powders in microgravity. This was proven on several sounding rocket flights, on which occasions Zr-based metallic glass parts produced by additive manufacturing in space were built. The findings of this work demonstrate that building parts using powder feedstock, which is more compact to transport into space than wire, is possible in microgravity environments. This thus significantly advances ISRU and ISM and paves the way for future tests in prolonged microgravity settings.