bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogenic metallic nanoparticles as game-changers in targeted cancer therapy: recent innovations and prospects
Authors: Todaria Moulika , Maity Dipak , Awasthi Rajendra 
Published: February 2024

Abstract
Background
Cancer is a significant global health issue, resulting from uncontrolled cell division leading to abnormal cell or tissue growth. Traditional chemotherapeutic techniques have investigated a wide variety of pharmaceutically active molecules despite their poor bioavailability, quick renal clearance, inconsistent distribution, and unavoidable side effects. Green synthesis, unlike chemical methods, prioritizes eco-friendliness and cost-effectiveness. Using natural sources like plant extracts, it minimizes environmental impact, reduces costs, and aligns with sustainability goals. Operating under milder conditions, it consumes less energy compared to traditional approaches. Green synthesis is a highly promising and efficient method for producing nanoparticles due to its versatility and scalability.

Main body
Nanotechnology is making progress in cancer treatment because of nanoparticles' tiny size, large surface area, adaptability, and functionality, as well as their potential to induce apoptotic pathways and fast penetration or internalization into cancer cells. Biosynthesis of metallic nanoparticles using plant or microbe extracts is attracting attention to replace toxic chemicals with phytochemicals that can act as reducing, capping, or stabilizing agents and improve metallic nanoparticles biocompatibility, antitumor, and antioxidant properties. This review focuses on biosynthesized metallic nanoparticles and their anticancer effects on breast, prostate, skin, cervical, colorectal, lung, and liver cancer.

Conclusion
Biosynthesis of nanoparticles for cancer therapy stands at the forefront of innovative and sustainable approaches. Despite challenges, ongoing research demonstrates the potential of biosynthesis to revolutionize cancer nanomedicine, emphasizing the need for continued exploration and collaboration in this rapidly advancing field. Overall, this review offers a comprehensive understanding of the most recent developments in biosynthesized metallic nanoparticles for the treatment of cancer as well as their potential future applications in medicine.
Satisfaction and effectiveness of a digital health tool to improve health behavior counseling among adolescent and young adult cancer survivors: a randomized controlled pilot trial
Authors: Kepper Maura M. , Walsh-Bailey Callie , Zhao Min , Parrish Loni , Miller Zoe M. , Glasgow Russell E. , Fuentes Lisa de las , Yan Yan , Hayashi Robert J. , Brownson Ross C. , Foraker Randi E. 
Published: February 2024

Abstract
Background
This pilot study examined the preliminary effectiveness of the PREVENT digital intervention that supports health care teams in delivering health behavior counseling on cancer survivors’ motivation to change behavior, their physical activity and food intake behaviors, and cardiovascular health (CVH).

Methods
Clinicians (physicians, nurse practitioners) at three urban cancer survivorship clinics were trained to use PREVENT. Patients were randomized to the PREVENT intervention or a wait-list routine care control group. Eligibility criteria for patients included: between ages 12–39, overweight or obese, were at least 6-months post-active cancer treatment, and had sufficient English proficiency.

Results
Fifty-five participants were enrolled; 27 were randomized to the PREVENT intervention and 28 to wait-list routine care control. The majority of the participants (82%) identified as non-Hispanic white, with an average age of 19.8 (SD ± 5.2) years. Patients that received the PREVENT intervention had greater increases in their self-efficacy, vigorous activity and number of food recommendations met than those who received routine clinical care. Changes in willingness, knowledge, and CVH outcomes were not significant.

Conclusions
The PREVENT digital intervention may provide improvements in preventive behaviors among AYA cancer survivors by supporting care teams with delivering evidence-based, tailored behavior change recommendations and resources to support patient health.

Trial registration
This trial (NCT04623190) was registered on 11/02/2022.
Music therapy for depression: is it music to our ears?
Authors: Lomax Tessa 
Published: February 2024

SUMMARYMusic therapy has been a recognised form of therapy for mental illness for many years. This commentary on a Cochrane Review on music therapy for depression sheds light on the evidence. It aims to give further clinical context to the findings, to help guide practice and examine music therapy as an evidence-based practice. The review compares music therapy plus ‘treatment as usual’ (TAU) with TAU alone, music therapy with psychological therapy, and ‘active’ with ‘receptive’ music therapy (the two main types of music therapy). The review points to music therapy being beneficial for people with depression when combined with TAU (versus TAU alone) in the short term, as well as improving anxiety and functioning. We need more evidence looking at longer-term outcomes, comparing music therapy with psychological therapies and comparing different forms of music therapy.
Differences in Colorectal Cancer Awareness Between Vegetarians and Nonvegetarians: A National Cross-Sectional Study From Palestine
Authors: Elshami Mohamedraed , Albandak Maram , Alser Mohammed , Al-Slaibi Ibrahim , Ayyad Mohammed , Dwikat Mohammad F. , Naji Shoruq A. , Mohamad Balqees M. , Isleem Wejdan S. , Shurrab Adela , Yaghi Bashar , Ayyash Qabaja Yahya , Hamdan Fatma K. , Sweity Raneen R. , Jneed Remah T. , Assaf Khayria A. , Hmaid Mohammed M. , Awwad Iyas I. , Alhabil Belal K. , Alarda Marah N. , Alsattari Amani S. , Aboyousef Moumen S. , Aljbour Omar A. , AlSharif Rinad , Giacaman Christy T. , Alnaga Ali Y. , Abu Nemer Ranin M. , Almadhoun Nada M. , Skaik Sondos M. , Albarqi Shurouq I. , Abu-El-Noor Nasser , Bottcher Bettina 
Published: February 2024

PURPOSE To compare colorectal cancer (CRC) awareness between vegetarians and nonvegetarians in Palestine. MATERIALS AND METHODS The validated Bowel Cancer Awareness Measure and Cancer Awareness Measure-Mythical Causes Scale were translated into Arabic and used to assess awareness of CRC signs/symptoms, risk factors, and mythical causes. The total awareness score of each domain was calculated and categorized into tertiles; the top tertile was considered as good awareness. Multivariable logistic regression analysis was used to examine the association between being a vegetarian and displaying good awareness in each domain. RESULTS This study included 4,623 participants: 560 vegetarians (12.1%) and 4,063 nonvegetarians (87.9%). Lump in the abdomen was the most recognized CRC sign/symptom among both nonvegetarians (n = 2,969, 73.1%) and vegetarians (n = 452, 80.7%). Vegetarians were less likely than nonvegetarians to display good awareness of CRC signs/symptoms (odds ratio, 0.59 [95% CI, 0.48 to 0.72]). Lack of physical activity was the most identified modifiable CRC risk factor in both nonvegetarians (n = 3,368, 82.9%) and vegetarians (n = 478, 85.4%). Similarly, having a bowel disease was the most identified nonmodifiable risk factor among both nonvegetarians (n = 2,889, 71.1%) and vegetarians (n = 431, 77.0%). There were no associated differences between both groups in the awareness levels of CRC risk factors. The most recognized food-related CRC causation myth in nonvegetarians was drinking from plastic bottles (n = 1,023, 25.2%), whereas it was eating burnt food in vegetarians (n = 176, 31.4%). Having a physical trauma was the most recognized food-unrelated myth in both nonvegetarians (n = 2,356, 58.0%) and vegetarians (n = 396, 70.7%). There were no associated differences in the awareness of CRC causation myths between both groups. CONCLUSION Awareness of CRC was notably low in both Palestinian vegetarians and nonvegetarians. Particularly, vegetarians demonstrated lower awareness of CRC signs and symptoms.
AUTOMATING THE PROCESS OF PREPARING THE SCHOOL TIMETABLE
Authors: Petrosyan Ashot S. , Surmachevskaya Angelica A. , Safonova Ekaterina A. , Kuznetsova Evelina M. , Gareeva Gulnara A. 
Published: February 2024

This paper presents a development that optimizes the process of educational scheduling by creating algorithms that automatically distribute the load of the educational process and take into account all the preferences of teachers. One of the currently popular platforms for deploying these developments is the google tables platform for creating google tables and creating code based on google app script. The peculiarity of the system implemented with the help of this platform is the ease of use and minimization of resources spent on software storage, which greatly simplifies interaction with the system.
Purpose – create a tool for drawing up a study schedule, interacting with a database created in Google Tables, interacting with participants of an educational institution online, which saves personal time of teachers and employees of the dean’s office.
Method or methodology of the work: the article discusses a way to optimize the creation of a weekly schedule, taking into account the convenience of the teacher in the distribution of pairs and taking into account the load of the educational process by creating algorithms based on Google app script. For implementation, online tables are used that are accessible to all teachers and employees of the dean’s office, updated in real time, Tables created in Google and the google app script programming language.
Result: a unique tool has been developed that implements the functions of adding, storing, interacting and round-the-clock access to training schedule data.
Scope of application of the results: the curriculum, stored in online tables and updated by the dean’s office staff, should be used for monitoring by each teacher, keeping track of their time of couples in educational institutions.
ON THE ISSUE OF THE EFFICIENCY OF THE USE OF ELECTRIC TRANSPORT IN CITIES
Authors: Konovalova Tatyana V. , Nadiryan Sofiya L. , Senin Ivan S. , Kotsurba Sofiya V. 
Published: February 2024

In this article, the authors consider issues related to the efficiency of the use of electric transport in cities. Currently, environmentally friendly modes of transport, including means of individual mobility, are becoming increasingly relevant. To determine the prospects for the development of electric transport in cities, it is necessary to evaluate the performance indicators of its work. Based on the experience of using electric transport, it can be concluded that the development of this type of transport in the cities of our country is a promising direction.
The purpose: the purpose of this study is the efficiency of the use of electric transport in cities. Within the framework of achieving the set goal, it is necessary to solve the following tasks: analysis of the characteristics and effectiveness of various types of electric transport; analysis of the experience of using electric transport in urban conditions.
Method or methodology of the work: when conducting research, the authors used such research methods as analysis, practical modeling.
Results: to date, the following results have been achieved: comparative costs of electric transport and other types of urban transport have been analyzed. The international experience of using electric transport is analyzed. The technical characteristics of vehicles, the consumption of electrical energy, the possibility of charging and operation in urban conditions are considered.
Scope of application of the results: research activity on the development of new approaches in the field of organization of transportation on vehicles with alternative energy sources.
Exosomes - breakthrough in the regenerative medicine and a way to improve the quality of the life
Authors: Brzozowska Anna , Maj-Dziedzic Monika , Sikora Marcelina , Zarzycka Marta , Plewniok Ines , Dubiel Jeremiasz , Maj Adrian , Warno Martyna , Kozik Wiktor , Śmietana Greta 
Published: February 2024

Introduction
Exosomes are small, membrane-bound extracellular vesicles that play a pivotal role in intercellular communication. Exosomes have garnered significant interest in regenerative medicine due to their unique properties that support tissue repair, regeneration, and healing. These extracellular vesicles play a crucial role in intercellular communication, and their regenerative potential makes them promising tools in the field of regenerative medicine.

Purpose of the study
This review aims to present the regenerative properties of exosomes and their clinical applications in many fields of medicine. The main aim is to present exosomes as a substance that restores health, youth and vitality.

Material and method
Literature review was primarily based on scientific materials, English and Polish databases and original research. The following English keywords and its Polish equivalents were used to search Google Scholar and PubMed: “ exosomes", “regenerative medicine”, “stem cells”.
Are Audit Committees Overloaded? Evidence from the Effect of Financial Risk Management Oversight on Financial Reporting Quality
Authors: Ashraf Musaib , Choudhary Preeti , Jaggi Jacob 
Published: February 2024

Audit committee (AC) responsibilities have increased over time, prompting concerns that overloading the AC with too many duties may impair the AC’s ability to oversee financial reporting. Using new AC charter-based proxies to measure AC responsibilities, we find that an emphasis on the AC overseeing financial risk management (which is a noncore AC duty) is associated with worse financial reporting quality, as proxied by restatements—consistent with the argument of AC overload by distraction. This overload effect is attenuated when an AC has more directors to share duties or when the AC retains an expert auditor who can serve as a substitute for AC oversight. This overload effect is accentuated when AC members are busy with multiple board appointments or when the external auditor is busy with other audits. We also find that AC financial risk oversight is associated with more AC meetings and greater turnover of AC directors, consistent with the notion of overload. In sharp contrast, we find that greater AC oversight over internal controls (which is a core AC duty) is associated with improved financial reporting quality. Overall, we document that the nature of AC duties impacts the AC’s ability to promote financial reporting quality and that noncore duties may overload ACs. This paper was accepted by Suraj Srinivasan, accounting. Funding: The authors are grateful for funding provided by the Eller College of Management at the University of Arizona, the Broad College of Business at Michigan State University, and the Carson College of Business at Washington State University. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.00360 .
Nontraded Sector Growth Risks and Economic Sizes in International Asset Pricing
Authors: Tô Thuy-Duong , Tran Ngoc-Khanh 
Published: February 2024

Output fluctuations in nontraded sectors are an important country-specific risk factor because nontraded outputs are only consumed domestically. In interest rate markets, countries with higher nontraded output growth risks are associated with stronger motives for precautionary savings and lower interest rates. In currency markets, strategies with higher exposures to nontraded output growth risks offer higher average excess returns. Economic sizes play an important role in exacerbating the pricing impact of nontraded output growth risks as it requires larger international trades to mitigate nontraded output risks of larger economies. However, because economic sizes are functions of outputs in equilibrium, output growth risks also explain this role of economic sizes in international asset pricing. This paper was accepted by Agostino Capponi, finance. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.03697 .
Advocacy and Research Coming Together
Authors: Adams Askia 
Published: February 2024

Abstract
My name is Askia Adams and, in this article, I share my perspective and experience with research and advocacy. I have recently started a job as a researcher, and I am learning a lot about how research and advocacy complement each other. It’s exciting to be able to learn new research skills. It has been challenging to start as a researcher. I’ve been working on learning the tools I need to be a researcher. There is a lot to learn and a lot of skills to develop. My team supports me in many ways, which I describe in the article. It is crucial to have self-advocate involvement in research because the research affects our lives and we have unique insights from our lived experience. For years, we have been left out of the design of research. When self-advocates are involved, the research is going to be more meaningful to people with disabilities.
Fehlerkulturen in Organisationen: Was sie uns sagen und wie wir aus ihnen lernen können
Authors: Reaper Monika 
Published: February 2024

Zusammenfassung
Fehler werden immer und überall gemacht, mal mehr, mal weniger. Wenn wir aus Fehlern in unseren Bibliotheken, aber auch in anderen Einrichtungen lernen, dann können wir langfristig Arbeitsprozesse optimieren, die Service-Qualität in unseren Einrichtungen verbessern und innovativ sein. Damit erhöhen wir das Alleinstellungsmerkmal unserer Bibliothek im Wettbewerb mit digitalen Angeboten und Dienstleistungen und werden stärker als kompetenter Service-Partner von unseren Nutzern wahrgenommen. Dieser Artikel beschäftigt sich damit, wie die Fehlerkultur in Bibliotheken verbessert werden kann.
FRAMED: a framework facilitating insight problem solving
Authors: Isoda Sho , Shimizu Taro , Suzuki Tomio 
Published: February 2024

Abstract
Insight has been studied as an element of problem solving in the field of cognitive psychology and may play an important role in clinical reasoning. We propose a new strategy based on theories that promote insight that may help generate further diagnostic hypotheses by reviewing the interpretation of a case and an individual’s list of differential diagnoses from multiple perspectives: formation (F), re-encoding (R), analogy (A), modification (M), elaboration (E), and deliberation (D) (FRAMED). The FRAMED strategy may help clinicians overcome misinterpretations and cognitive bias by systematically reflecting on previous clinical reasoning processes from multiple perspectives.
Rethinking the Theoretical Foundation of Economics I: The Multilevel Paradigm
Authors: Wilson David Sloan , Snower Dennis J. 
Published: February 2024

Abstract
This article is the first of a series that offers a new paradigm for economics, the “multilevel paradigm,” using generalized Darwinism as its theoretical framework. Generalized Darwinism refers to all processes that combine the ingredients of variation, selection, and replication – not just genetic evolution – making it relevant to the cultural evolution of economic systems that are embedded in political, social, and environmental systems. We contrast the multilevel paradigm with the neoclassical paradigm and other schools of economic thought. The multilevel paradigm, like the neoclassical paradigm, provides an integrative framework for micro- and macro-economics. It also incorporates the meso level, comprising groups of various sizes, linking micro and macro. Other schools of economic thought are not fully integrative in this sense, constituting instead a form of diffuse pluralism. In the integrative framework of the multilevel paradigm, many important ideas that are currently on the periphery of economics are brought toward the core.
Digitalisierung im Gefängnis: Eine multiperspektivische Betrachtung der Ausweitung des Zugangs zu digitalen Geräten für Inhaftierte im österreichischen Straf- und Maßnahmenvollzug
Authors: Hofinger Veronika , Pflegerl Philipp 
Published: February 2024

Zusammenfassung
Der Strafvollzug wird international zunehmend digitalisiert. In vielen Ländern haben Strafgefangene bereits Zugang zu digitalen Geräten. Forschung zu »digital rehabilitation« zeigt die Chancen auf, die sich dadurch für die Verbesserung der Haftbedingungen und die Resozialisierung ergeben. Vor diesem Hintergrund sollen auch in Österreich Inhaftierte erweiterten Zugang zu digitalen Technologien erhalten. In Vorbereitung eines Pilotprojekts wurden 39 (zum Teil ehemalige) Inhaftierte in problemzentrierten Interviews, über 600 im Strafvollzug Beschäftigte in einer Online-Befragung und 15 Fachleute zu den Chancen und Risiken der Digitalisierung befragt. In diesem Artikel werden die Ergebnisse dieser Erhebungen präsentiert und miteinander in Beziehung gesetzt. Die Befragungen zeigen, dass in einigen Bereichen überraschend viel Einigkeit besteht; gleichzeitig unterstreichen die Ergebnisse der Personalbefragung, dass innerhalb der Justizwache ein großes Bewusstsein für die Sicherheitsrisiken der Digitalisierung besteht. Der Artikel stellt eine sozialwissenschaftliche Analyse der Bedingungen für eine sinnvolle und breit akzeptierte Ausweitung des Zugangs zu digitalen Geräten für Inhaftierte dar. Das Ziel der Resozialisierung darf dabei nicht als Legitimation für die Implementierung von digitalen Technologien verwendet werden, mit denen de facto andere Ziele, wie der Ausbau von Überwachung und Kontrolle, verfolgt werden. Bedenken und Widerstände eines Teils des Personals müssen zwar berücksichtigt werden, sollten jedoch nicht dazu führen, dass Inhaftierten auf Dauer der Zugang zu heute selbstverständlichen Tools und Kompetenzen einer digitalen Gesellschaft vorenthalten wird.
MicroRNA-302a enhances 5-fluorouracil sensitivity in HepG2 cells by increasing AKT/ULK1-dependent autophagy-mediated apoptosis
Authors: He Qiong , Li Li 
Published: February 2024

Abstract

Objectives
MicroRNA-302a (miR-302a) has been implicated in the oncogenic processes, but its role in hepatocellular carcinoma (HCC) chemoresistance and related mechanisms are still unclear. Therefore, the aim of this study was to investigate the role of miR-302a in HCC chemoresistance and elucidate its underlying mechanism.

Methods
In this study, we detected the level of miR-302a in HCC tissues (including chemoresistant and chemosensitive tissues), non-tumor tissues, liver cancer cell lines, and 5-fluorouracil (5-FU)-resistant cells (HepG2/R). Additionally, we conducted cell viability, apoptosis, and autophagy analyses as well as assessed the levels of cleaved caspase-3, cleaved caspase-9, microtubule-associated protein 1 light chain 3 beta II (LC3B-II), Akt, and UNC-51 like kinase 1 (ULK1) in HepG2 cells transfected with miR-302a mimic or inhibitor prior to 5-FU treatment. Lastly, we predicted the target of miR-302a and verified the relationship between miR-302a and Akt by luciferase reporter and functional repair assays.

Results
Our results revealed that miR-302a was down-regulated in HCC tissues (p<0.01), especially in chemoresistant tissues (p<0.01). Consistently, the miR-302a level exhibited a lower expression in HepG2/R cells compared to their parental cells (p<0.01). Furthermore, the 5-FU-induced apoptosis and autophagy of HepG2 cells were promoted by miR-302a over-expression and diminished by miR-302a inhibition (p<0.01). Target analysis revealed that miR-302a could directly target Akt. Moreover, miR-302a inhibited Akt expression and subsequently elevated ULK1 expression (p<0.01). Inhibition of ULK1 could abrogate the sensitization of overexpressed miR-302a to 5-FU in HepG2 cells (p<0.01).

Conclusions
Altogether, our results demonstrate that the down-regulation of miR-302a promotes 5-FU resistance in HCC by attenuating the Akt/ULK1 axis-dependent autophagy and apoptosis.