bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of natural habituation on coagulation responses to acute mental stress and recovery in men
Authors: Preckel Daniel , Zgraggen Lilian , Mischler Katharina , Kudielka Brigitte , Haeberli André , Fischer Joachim , von Känel Roland 
Published: November 2004

SummaryBlood coagulation activation might be one mechanism linking acute mental stress with coronary events. We investigated the natural habituation of coagulation responses and recovery to short-term mental stress.Three times with one-week intervals, 24 men (mean age 47 ± 7 years) underwent the same 13-min stressor (preparation, job interview, mental arithmetic). During each visit venous blood was obtained four times (baseline, immediately post-stress, 45 min of recovery, 105 min of recovery). Eight blood coagulation parameters were measured at weeks one and three. Acute stress provoked increases in von Willebrand factor antigen, fibrinogen, clotting factor FVII activity (FVII:C), FVIII:C, FXII:C (p’s ≤0.019), and D-dimer (N.S.). All coagulation parameters experienced full recovery except FVIII:C (p = 0.022). Stress did not significantly affect activated partial thromboplastin time and prothrombin time. At all time points FVIII:C and FXII:C levels were significantly higher at week one compared to week three (p’s ≤0.041). Before catheter insertion, systolic blood pressure (p = 0.001) and heart rate (p = 0.026) were relatively higher at week one. Unlike the magnitude of systolic blood pressure response to stress (p = 0.007) and of cortisol recovery from stress (p = 0.002), the magnitude of all coagulation responses to stress and the recovery from stress were similar in week one and week three. Sympathetic activation with anticipatory stress best explained increased baseline activity in FVIII and FXII at week one. An incapacity of the coagulation system to adapt to stress repeats is perhaps a consequence of evolution, but might also contribute to increased coronary risk in some individuals, particularly in those with cardiovascular diseases.
A variant thrombasthenic phenotype associated with compound heterozygosity of integrin β3-subunit: (Met124Val)β3 alters the subunit dimerization rendering a decreased number of constitutive active αIIbβ3 receptors
Authors: González-Manchón Consuelo , Butta Nora , Larrucea Susana , Arias-Salgado Elena , Alonso Sonia , López Angela , Parrilla Roberto 
Published: November 2004

SummaryWe report the analysis of a variant case of thrombasthenic phenotype that is a compound heterozygote for two mutations located within the metal ion dependent adhesion site (MIDAS) of the β3 subunit.The patient inherited a maternal allele carrying the Met124Val substitution and a paternal allele that changes Asp119 to Tyr. Phenotyping of the human platelet antigen 1 (HPA-1) showed that the platelet αIIbβ3 complex in the patient was mostly accounted for by the Asp 119Tyr allele that does not bind to fibrinogen (Fg). The patient showed agonistinduced binding of platelets to Fg but neither binding to PAC-1 nor cell aggregation could be detected, most likely due to the minute expression (≤5%) of αIIb(124Val)β3 receptors. CHO cells expressing (124Val)β3 showed a diminished surface expression of αIIbβ3, enhanced adhesion to immobilized Fg, and spontaneous aggregation in the presence of soluble Fg, suggesting that (124Val)β3 may confer constitutive activity to the αIIb(124Val)β3 receptors. A distinct feature of these cells is the failure of DTT to enhance the binding to soluble Fg and the formation of cell aggregates. The substitution of (124Met)β3 by either a polar or a positively charged amino acid restored the surface exposure and function of the αIIbβ3 receptors whereas a negatively charged residue did not.
The polymorphism of platelet membrane integrin α2β1 (α2807TT) is associated with premature onset of fetal loss
Authors: Gerhardt Andrea , Scharf Rüdiger , Mikat-Drozdzynski Barbara , Krüssel Jan , Bender Hans , Zotz Rainer 
Published: November 2004

SummaryInherited thrombophilia could increase susceptibility to adverse pregnancy outcomes such as fetal loss. We determined the G1691A mutation of the factorV gene (FVL), the G20210A mutation of the prothrombin gene, the C677T polymorphism of the methylenetetrahydrofolate-reductase (MTHFR) gene, the HPA-1 polymorphism of the β3 subunit of the platelet integrin αIIbβ3 and the C807T polymorphism of the α2 subunit of integrin α2 β1 in 104 women with fetal loss and 277 normal women. In a subgroup analysis of women with recurrent early fetal loss (n=34), the prevalence of the genetic markers did not differ significantly between the women with early fetal loss and the normal women. However, in this subgroup of patients the onset of fetal loss was significantly earlier in women with the α2807TT genotype (7.1 ± 1.9 vs. 8.8 ± 1.5 weeks, p=0.001). No such significant difference was observed in carriers of the other genetic markers. In the subgroup analysis of women with late fetal loss (n=70), only the prevalence of heterozygous FVL was significantly associated with late fetal loss (odds ratio 3.2, p=0.002). There was no significant association of any genetic risk factor with premature fetal loss in the subgroup analysis of women with at least one late miscarriage.This study demonstrates a significant association of the α2 807TT genotype of the platelet membrane integrin α2β1 with premature onset of early fetal loss. It appears that this risk factor does not induce the pathomechanism, but modulates the course of fetal loss. Furthermore, our study confirms the association of FVL with late fetal loss.
Rosuvastatin exerts favourable effects on thrombosis and neointimal growth in a mouse model of endothelial injury
Authors: Schäfer Katrin , Kaiser Kilian , Konstantinides Stavros 
Published: November 2004

SummaryApart from reducing systemic lipid levels, statins may improve the clinical course of atherosclerosis by exerting favourable pleiotropic effects on the vessel wall.We studied the effects of rosuvastatin, a new, potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on vascular remodelling after endothelial injury in the hyperlipidaemic apolipoprotein E-knockout (apoE-/-) mouse. ApoE-/- mice, 22-weeks-old, were injected daily with rosuvastatin at a low (1 mg/kg; n=27) or high dosage (10 mg/kg; n=24), or with vehicle alone (n=26).After treatment for 2 weeks,endothelial injury and thrombosis of the carotid artery was induced with 10% ferric chloride.Treatment was then resumed for a 3-week period.Although statin treatment did not affect the plasma lipid levels of mice, mean times to arterial thrombosis were prolonged in the low-dose and the high-dose group compared to controls (P<0.05 and P<0.01 respectively). Interestingly, rosuvastatin withdrawal 4 days before injury completely reversed the antithrombotic effects of the drug. In follow-up studies 3 weeks after injury,deposition of fibrin in the vessel wall was significantly reduced in the rosuvastatin-treated animals. There was an increase in the content of α -actin-positive smooth muscle cells (P =0.008) and collagen fibers (P<0.001), and a concomitant decrease in the number of oxLDL-containing macrophages (P<0.001). Overall, the neointimal area and the severity of luminal stenosis were significantly reduced in statin-treated mice. Thus, rosuvastatin attenuates arterial thrombosis and neointima formation, and it may stabilise vascular lesions developing after endothelial injury in mice.These effects are independent of systemic lipid lowering.
Sensory hypoinnervation in club foot
Authors: Ahmed M. , Ahmed N. , Khan K. M. , Umer M. , Rashid H. , Hashmi P. , Umar M. 
Published: November 2004

We have compared the density of nerve fibres in the synovium in club foot with that of specimens obtained from the synovium of the hip at operations for developmental dysplasia. The study focused on the sensory neuropeptides substance P; calcitonin gene-related peptide; protein gene product 9.5, a general marker for mature peripheral nerve fibres; and growth associated protein 43, a neuronal marker for new or regenerating nerve fibres. In order to establish whether there might be any inherent difference we analysed the density of calcitonin gene-related peptide-positive nerve fibres in the hip and ankle joints in young rats. Semi-quantitative analysis showed a significant reduction in the number of sensory and mature nerve fibres in the synovium in club foot compared with the control hips. Calcitonin gene-related peptide (CGRP) positive fibres were reduced by 28%, substance P-positive fibres by 36% and protein gene product 9.5-positive fibres by 52% in club foot. The growth associated protein 43-positive fibres also seemed to be less in six samples of club foot. No difference in the density of CGRP-positive nerve fibres was observed in the synovium between ankle and hip joints in rats. The lack of sensory input may be responsible for the fibrosis and soft-tissue contractures associated with idiopathic club foot.
Impaction femoral allografting and cemented revision for periprosthetic femoral fractures
Authors: Tsiridis E. , Narvani A. A. , Haddad F. S. , Timperley J. A. , Gie G. A. 
Published: November 2004

We reviewed retrospectively the outcome of the treatment by impaction grafting of periprosthetic femoral fractures around loose stems in 106 patients with Vancouver type-B2 and type-B3 fractures. Eighty-nine patients had a cemented revision with impaction grafting and a long or short stem. The remaining 17 had cemented revision without impaction grafting. Fractures treated by impaction grafting and a long stem were more than five times likely to unite than those treated by impaction grafting and a short stem (odds ratio = 5.5, 95% confidence interval (CI) 1.54 to 19.6; p = 0.009). Furthermore, those with impaction grafting and a long stem were significantly more likely to unite than those with a long stem without impaction grafting (odds ratio = 4.07, 95% CI 1.10 to 15.0; p = 0.035). There was also a trend towards a higher rate of union in those treated by impaction grafting than in those without (odds ratio = 2.69, 95% CI 0.86 to 8.45; p = 0.090). Impaction grafting is being increasingly widely used for the restoration of femoral bone stock. It can be successfully applied to periprosthetic femoral fractures but a long stem should be used to bypass the distal fracture line.
The flexion gap in normal knees
Authors: Tokuhara Y. , Kadoya Y. , Nakagawa S. , Kobayashi A. , Takaoka K. 
Published: November 2004

Varus and valgus joint laxity of the normal living knee in flexion was assessed using MRI. Twenty knees were flexed to 90° and were imaged in neutral and under a varus-valgus stress in an open MRI system. The configuration of the tibiofemoral joint gap was studied in slices which crossed the epicondyles of the femur. When a varus stress was applied, the lateral joint gap opened by 6.7 ± 1.9 mm (mean ± sd; 2.1 to 9.2) whereas the medial joint gap opened by only by a mean of 2.1 ± 1.1 mm (0.2 to 4.2). These discrepancies indicate that the tibiofemoral flexion gap in the normal knee is not rectangular and that the lateral joint gap is significantly lax. These results may be useful for adequate soft-tissue balancing and bone resection in total knee arthroplasty and reconstruction surgery on ligaments.
Phenol
Authors: Weber Manfred , Weber Markus , Kleine‐Boymann Michael 
Published: November 2004

AbstractThe article contains sections titled:1.Introduction2.Physical Properties3.Chemical Properties4.Production4.1.Cumene Oxidation (Hock Process)4.2.Toluene Oxidation4.3.Phenol from Coal4.4.Other Processes4.4.1.Sulfonation of Benzene4.4.2.Chlorination of Benzene4.4.3.Direct Oxidation of Benzene5.Environmental Protection6.Quality Specifications7.Storage and Transportation8.Uses and Economic Aspects9.Toxicology and Occupational Health
Resonant geometries for circulation pattern macroinstabilities in a stirred tank
Authors: Roussinova V. T. , Kresta S. M. , Weetman R. 
Published: November 2004

AbstractCirculation pattern macroinstabilities and precessing vortices are known to exist in stirred tanks, but until recently they have eluded a full quantitative analysis. In this article, frequency analysis of the axial velocity reveals a resonant frequency and geometry for the 45° pitched‐blade turbine (PBT) in a flat‐bottom cylindrical tank. Unlike other axial impellers, such as the hydrofoils A310 and HE3, the PBT produces a large‐scale circulation macroinstability at the scale of the vessel diameter. The macroinstability is superimposed on the turbulent random fluctuations with a timescale that is very long compared to the blade passage frequency and the inertial convective range of the turbulent cascade. In this article it is shown that the circulation pattern macroinstabilities generated by the 45° PBT are coherent and propagate throughout the tank only under very specific conditions (D = T/2 and C/D = 0.50). The normalized frequency of the coherent macroinstability, or Strouhal number, is fMI/N = 0.186. This corresponds to a period of roughly five rotations of the impeller, or 20 individual blade passages. The laser Doppler velocimeter data used in this work are unevenly spaced because they are collected in burst detection mode. This severely complicates spectral or frequency analysis. Standard algorithms such as the fast Fourier transform, autocorrelation methods, and wavelet analysis all require evenly spaced data. The Lomb periodogram was successfully used to extract the low‐frequency content of the unevenly spaced data with a higher accuracy than is possible with other methods. The Lomb method also eliminates a short time‐averaging step that was required in earlier work. © 2004 American Institute of Chemical Engineers AIChE J, 50: 2986–3005, 2004
Increased D1 dopamine receptor signaling in levodopa‐induced dyskinesia
Authors: Aubert Incarnation , Guigoni Céline , Håkansson Kerstin , Li Qin , Dovero Sandra , Barthe Nicole , Bioulac Bernard H. , Gross Christian E. , Fisone Gilberto , Bloch Bertrand , Bezard Erwan 
Published: November 2004

AbstractInvoluntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Although changes affecting D1 and D2 dopamine receptors have been studied in association with this condition, no causal relationship has yet been established. Taking advantage of a monkey brain bank constituted to study levodopa‐induced dyskinesia, we report changes affecting D1 and D2 dopamine receptors within the striatum of normal, parkinsonian, nondyskinetic levodopa‐treated parkinsonian, and dyskinetic levodopa‐treated parkinsonian animals. Whereas D1 receptor expression itself is not related to dyskinesia, D1 sensitivity per D1 receptor measured by D1 agonist‐induced [35S]GTPγS binding is linearly related to dyskinesia. Moreover, the striata of dyskinetic animals show higher levels of cyclin‐dependent kinase 5 (Cdk5) and of the dopamine‐ and cAMP‐regulated phosphoprotein of 32kDa (DARPP‐32). Our data suggest that levodopa‐induced dyskinesia results from increased dopamine D1 receptor–mediated transmission at the level of the direct pathway. Ann Neurol 2004
Preparation and properties of cellulose–olefinic thermoplastic elastomer composites
Authors: Nagatani Asahiro , Endo Takashi , Hirotsu Takahiro , Furukawa Mutsuhisa 
Published: November 2004

AbstractFibrous cellulose (fibrous W400) was substantially dried and mechanically milled with stearic acid under several conditions. Milled with 2 wt% stearic acid at a rotational speed of 200 rpm for 24 h, fibrous W400 were pulverized into fine flake‐shaped particles (flake‐shaped W400) with an average particle size of ca. 10 μm. Composites of the flake‐shaped W400 and olefinic thermoplastic elastomer (TPV) were prepared under melt mixing and passed through an open roll to orient the particles. The tensile properties of the composites without any compatibilizer were deteriorated with increasing content of the particles. However, the tensile modulus and hardness of the composites prepared by the addition of a compatibilizer (CA‐60) were increased with increasing content of particles, because of the strong adhesion between flake‐shaped W400 and TPV. The damping properties of the composites were improved in comparison with TPV. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 95: 144–148, 2005
Airtight butyl rubber under high pressures in the storage tank of CAES‐G/T system power plant
Authors: Terashita Fumihiro , Takagi Shingo , Kohjiya Shinzo , Naito Yasutoshi 
Published: November 2004

AbstractThe compressed air up to the maximum pressure of 8 MPa is stored in the storage facility of the Compressed Air Energy Storage Gas Turbine (CAES‐G/T). The interior of the storage facility is covered by air‐tight sheets to prevent a leak of this compressed air. Electricity by a power‐generating system using such a facility is the first of its kind in the world. So, we have examined the materials of the airtight sheet and found that polymeric materials were suitable. Then, a normal pressure gas permeation test was done on several synthetic resins and rubbers. Butyl rubber (IIR) was found to show the smallest gas permeability. Moreover, a high‐pressure gas permeation test was done on IIR and natural rubber (NR). The permeability of IIR at 10 MPa was estimated, and it was clear that IIR was a suitable air‐tight material for CAES‐G/T. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 95: 173–177, 2005
Phase behavior of binary and ternary mixtures of poly(ethylene‐co‐octene)–hydrocarbons
Authors: Lee Sang‐Ho 
Published: November 2004

AbstractPoly(ethylene‐co‐octene) (PEO) is a new thermoplastic elastomer that has the wide variation in mechanical, thermal, optical, and elastomeric properties. The variety of PEO properties results from incorporation octene comonomer in polyethylene backbone. Because of the wide difference in the copolymer properties, it is important to know the phase boundary to optimize the copolymerization and separation processes of PEO. The cloud‐point and bubble‐point curves for poly(ethylene‐co‐15.3 mol % octene) (PEO15), which has 15.3 mol % octene repeat unit in the backbone structure, were determined in n‐pentane, n‐hexane, n‐heptane, and n‐octane. The miscibility of PEO15 in normal alkane enlarges with the size of the normal alkane because of the increasing dispersion interactions related to polarizability. The phase behavior for the ternary systems of PEO15–ethylene–octene was also investigated, where ethylene and 1‐octene are monomer and comonomer of PEO. As the concentration of ethylene in the ternary mixture increases, the miscibility of PEO15 dramatically decreases. Adding 64 wt % ethylene into the ternary mixture increases the pressure, dissolving PEO15 up to 1000 bar. In pure ethylene, PEO15 was not dissolved up to 1900 bar, 160°C. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 95: 161–165, 2005
Stream crossings and the conservation of diadromous invertebrates in South Pacific island streams
Authors: Resh Vincent H. 
Published: November 2004

Abstract
Most non‐insect invertebrates that occur in streams on tropical Pacific islands are diadromous; they live as juveniles and adults in streams but have larvae that migrate to the ocean to complete their development before returning to fresh water.
The type of crossing used in the construction of roads to traverse small streams can impede upstream migration and, consequently, colonization of diadromous fauna above the stream crossing.
A stream in the Opunohu Valley, Moorea, French Polynesia, had the same diadromous fauna of atyid shrimps, palaemonid prawns, and neritid snails occurring above and below an 8 m wide, 10 m long, bottomless culvert (i.e. an open‐bottom bridge) built to flow over natural substrates. However, no diadromous species were found upstream of two 1 m diameter, 8 m long concrete pipes used for a culverted stream crossing. The increased shear stress in the pipe and subsequent downstream erosion of the stream bed probably inhibited upstream migration.
Modifications to culverted stream crossings, which are widely used on tropical islands, can reduce migration barriers and prevent upstream loss of diadromous stream fauna.
Copyright © 2004 John Wiley & Sons, Ltd.
Comparison of a virtual microscope laboratory to a regular microscope laboratory for teaching histology
Authors: Harris Tonya , Leaven Timothy , Heidger Paul , Kreiter Clarence , Duncan James , Dick Fred 
Published: November 2004

AbstractEmerging technology now exists to digitize a gigabyte of information from a glass slide, save it in a highly compressed file format, and deliver it over the web. By accessing these images with a standard web browser and viewer plug‐in, a computer can emulate a real microscope and glass slide. Using this new technology, the immediate aims of our project were to digitize the glass slides from urinary tract, male genital, and endocrine units and implement them in the Spring 2000 Histology course at the University of Iowa, and to carry out a formative evaluation of the virtual slides of these three units in a side‐by‐side comparison with the regular microscope laboratory. The methods and results of this paper will describe the technology employed to create the virtual slides, and the formative evaluation carried out in the course. Anat Rec (New Anat) 265:10–14, 2001. © 2001 Wiley‐Liss, Inc.
Transmembrane voltage induced on altered erythrocyte shapes exposed to RF fields
Authors: Muñoz S. , Sebastián J.L. , Sancho M. , Miranda J.M. 
Published: November 2004

AbstractIn this article, the transmembrane voltage induced on erythrocyte, codocyte, ovalocyte and spherocyte cell models exposed to a linearly polarised electromagnetic plane wave of frequency 1800 MHz is calculated. For this purpose, a finite element (FE) numerical technique with adaptive meshing is used. The results show that the value of the induced voltage on the original erythrocyte shape is higher than the one observed on the rest of the altered cell geometries studied. The erythrocyte shape and the membrane electric permittivity are shown to play a fundamental role on the values of the induced transmembrane voltage. Bioelectromagnetics 25:631–633, 2004. © 2004 Wiley‐Liss, Inc.
Accepting its Random Coil Nature Allows a Partial NMR Assignment of the Neuronal Tau Protein
Authors: Smet Caroline , Leroy Arnaud , Sillen Alain , Wieruszeski Jean‐Michel , Landrieu Isabelle , Lippens Guy 
Published: November 2004

AbstractA combined strategy to obtain a partial NMR assignment of the neuronal Tau protein is presented. Confronted with the extreme spectral degeneracy that the spectrum of this 441 amino acid long unstructured protein presents, we have introduced a graphical procedure based on residue type‐specific product planes. Combining this strategy with the search for pairwise motifs, and combining the spectra of different Tau isoforms and even of peptides derived from the native sequence, we arrive at a partial assignment that is sufficient to map the interactions of Tau with its molecular partners. The obtained assignments equally confirm the absence of regular secondary structure in the isolated protein.