bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitrogen‐Doped Carbon Nanotubes with Large Interplanar Distances toward Fast Potassium Storage
Authors: Wang Yun , Keteklahijani Yalda Zamani , Wang Ruishuai , Liu Liang , Jiang Wenfeng , Guo Jia , Yang Dong , Sundararaj Uttandaraman , Arjmand Mohammad , Liu Jian 
Published: October 2023

AbstractOne of the main challenges potassium‐ion batteries (PIBs) face is the lack of structurally stable anodes with high reactivity and fast kinetics for reversible potassium insertion/extraction. Herein, nitrogen‐doped carbon nanotubes (N‐CNTs) are synthesized using a straightforward method assisted by a Co‐based catalyst. The as‐synthesized N‐CNTs possess interlayer distances up to 0.38 nm and nitrogen‐doping content of 2.2 at.%. Compared to the undoped CNTs (U‐CNTs), N‐CNTs exhibit a promising initial specific capacity of 568 mAh g−1 at 0.1 A g−1, as well as excellent long‐term cycling performance of 104, 82, and 76 mAh g−1 at a high current of 0.5, 1, and 2 A g−1 for 500 cycles. The cyclic voltammetry (CV) measurements reveal the potassium storage mechanism of N‐CNTs, which combines the major capacitive mechanisms and the secondary diffusion, and successfully avoids inconspicuous voltage plateau. The kinetic analysis of the galvanostatic intermittent titration technique and ex situ X‐ray photoelectron spectroscopy spectra show fast reaction kinetics and low side effects and degradation for the N‐CNTs anodes during the potassiation/de‐potassiation process. This study provides a straightforward method to synthesize heteroatom‐doped carbonaceous anode materials and achieves superior electrochemical properties with cost‐effectiveness and material sustainability.
Ions‐Silica Percolated Ionic Dielectric Elastomer Actuator for Soft Robots
Authors: Choi Hanbin , Kim Yongchan , Kim Seonho , Kim So Young , Kim Joo Sung , Yun Eseudeo , Kweon Hyukmin , Amoli Vipin , Choi U. Hyeok , Lee Hojin , Kim Do Hwan 
Published: October 2023

AbstractSoft robotics systems are currently under development using ionic electroactive polymers (i‐EAP) as soft actuators for the human‐machine interface. However, this endeavor has been impeded by the dilemma of reconciling the competing demands of force and strain in i‐EAP actuators. Here, the authors present a novel design called “ions‐silica percolated ionic dielectric elastomer (i‐SPIDER)”, which exhibits ionic liquid‐confined silica microstructures that effectively resolve the chronic issue of conventional i‐EAP actuators. The i‐SPIDER actuator demonstrates remarkable electromechanical conversion capacity at low voltage, thanks to improved ion accumulation facilitated by interpreting electrode polarization at the electrolyte‐electrode interface. This approach concurrently enhances both strain (by approximately 1.52%) and force (by roughly 1.06 mN) even at low Young's modulus (merely 5.9 MPa). Additionally, by demonstrating arachnid‐inspired soft robots endowed with user‐desired tasks through control of various form factors, the development of soft robots using the i‐SPIDER that can concomitantly enhance strain and force holds promise as a compelling avenue for ushering in the next generation of miniaturized, low‐powered soft robotics.
Roles of Blend Morphology and Energy Level Alignment in Determining Open‐Circuit Voltage and Fill Factor of Ternary All‐Polymer Solar Cells
Authors: Liang Zhiyuan , Benten Hiroaki , Hagio Ren , Cho Yongyoon , Pandey Manish , Nakamura Masakazu 
Published: October 2023

AbstractTuning the open‐circuit voltage (VOC) and fill factor (FF) without sacrificing the short‐circuit current density is crucial for achieving performance advantages in ternary blend organic solar cells as an alternative to the binary ones. This study investigates ternary all‐polymer solar cells comprised of two polymer donors (D1 and D2) and one polymer acceptor (A), using two types of D2 polymers with different compatibilities with D1. As demonstrated by photoelectron yield spectroscopy, the ionization energy (IE) of the ternary blends continuously shifts between the IEs of D1:A and D2:A binary blends when D2 forms a single indistinguishable domain with D1. In contrast, the IE of the blends does not exhibit any noticeable change when D2 induces distinct phase separation with D1. Models describing the blend composition dependence of the VOC and FF are constructed by correlating the effects of the blend morphology and the shift in the energy level of the hole‐transporting state in the ternary blends. This study demonstrates that a pseudo‐binary blend morphology with a mixed D1 and D2 donor domain and an A acceptor domain is necessary to obtain a broad tunability of VOC and tolerance of FF to the blend composition in ternary all‐polymer solar cells.
Neither lysigenous nor just oil: Demystifying myrtaceous secretory cavities
Authors: Richit José F. , Díaz Shirley V. N. , Dick Luís F. P. , Mariath Jorge E. A. 
Published: October 2023

AbstractPremiseLeaf subepidermal secretory cavities are a notable trait in Myrtaceae, but their formation is still controversial because of the lack of consensus on their ontogeny among authors. Knowledge about the compounds present in these cavities has grown over the last few years, demonstrating that terpenoid‐rich oils are not their unique content. These two points are the focus of this study on the ontogeny, structure, and contents of secretory cavities in neotropical Myrtaceae.MethodsWe used histochemical tests and Raman analysis to verify the basic chemical composition of the cavity contents of nine species. We studied the ontogeny of glands in one species, comparing aldehyde‐fixed tissues and fresh sections mounted in an inert medium.ResultsWe observed schizogenous development and appearance of the secretory cavities and found that sample processing may induce cell breakdown, which can be misinterpreted as lysigeny. The content of these cavities contains putative terpenes, resins, carbonyl groups, and flavonoids.ConclusionsOur findings support the hypothesis that the lysigenous appearance of the oil glands is a technical artifact. These tissue distortions must be considered when interpreting the development of this type of secretory structure. Moreover, the basic analyses of chemical constituents show for the first time that the glands of neotropical Myrtaceae are potential reservoirs of some compounds such as flavonoids previously reported as novelties for a few other myrtaceous species. Because some of them are non‐lipid compounds, the idea that the glands are just oil repositories is no longer applicable.
Erythropoietin downregulates red blood cell clearance, increasing transfusion efficacy in severely anemic recipients
Authors: Casimir Madeleine , Colard Martin , Dussiot Michael , Roussel Camille , Martinez Anaïs , Peyssonnaux Carole , Mayeux Patrick , Benghiat Samantha , Manceau Sandra , Francois Anne , Marin Nathalie , Pène Frédéric , Buffet Pierre A. , Hermine Olivier , Amireault Pascal 
Published: October 2023

AbstractRed blood cells (RBC) transfusion is used to alleviate symptoms and prevent complications in anemic patients by restoring oxygen delivery to tissues. RBC transfusion efficacy, that can be measured by a rise in hemoglobin (Hb) concentration, is influenced by donor‐, product‐, and recipient‐related characteristics. In some studies, severe pre‐transfusion anemia is associated with a greater than expected Hb increment following transfusion but the biological mechanism underpinning this relationship remains poorly understood. We conducted a prospective study in critically ill patients and quantified Hb increment following one RBC transfusion. In a murine model, we investigated the possibility that, in conjunction with the host erythropoietic response, the persistence of transfused donor RBC is improved to maintain a highest RBC biomass. We confirmed a correlation between a greater Hb increment and a deeper pre‐transfusion anemia in a cohort of 17 patients. In the mouse model, Hb increment and post‐transfusion recovery were increased in anemic recipients. Post‐transfusion RBC recovery was improved in hypoxic mice or those receiving an erythropoiesis‐stimulating agent and decreased in those treated with erythropoietin (EPO)‐neutralizing antibodies, suggesting that EPO signaling is necessary to observe this effect. Irradiated recipients also showed decreased post‐transfusion RBC recovery. The EPO‐induced post‐transfusion RBC recovery improvement was abrogated in irradiated or in macrophage‐depleted recipients, but maintained in splenectomized recipients, suggesting a mechanism requiring erythroid progenitors and macrophages, but which is not spleen‐specific. Our study highlights a physiological role of EPO in downregulating post‐transfusion RBC clearance, contributing to maintain a vital RBC biomass to rapidly cope with hypoxemia.
Clinical utility of early rapid genome sequencing in the evaluation of patients with differences of sex development
Authors: Aekka Apoorva , Weisman Allison Goetsch , Papadakis Jaclyn , Yerkes Elizabeth , Baker Joshua , Keswani Mahima , Weinstein Joanna , Finlayson Courtney 
Published: October 2023

AbstractEstablishing an early and accurate genetic diagnosis among patients with differences of sex development (DSD) is crucial in guiding the complex medical and psychosocial care they require. Genetic testing routinely utilized in clinical practice for this population is predicated upon physical exam findings and biochemical and endocrine profiling. This approach, however, is inefficient and unstandardized. Many patients with DSD, particularly those with 46,XY DSD, never receive a molecular genetic diagnosis. Rapid genome sequencing (rGS) is gaining momentum as a first‐tier diagnostic instrument in the evaluation of patients with DSD given its ability to provide greater diagnostic yield and timely results. We present the case of a patient with nonbinary genitalia and systemic findings for whom rGS identified a novel variant of the WT1 gene and resulted in a molecular diagnosis within two weeks of life. This timeframe of diagnosis for syndromic DSD is largely unprecedented at our institution. Rapid GS expedited mobilization of a multidisciplinary medical team; enabled early understanding of clinical trajectory; informed planning of medical and surgical interventions; and guided individualized psychosocial support provided to the family. This case highlights the potential of early rGS in transforming the evaluation and care of patients with DSD.
Deep Resequencing of the 1q22 Locus in Non‐Lobar Intracerebral Hemorrhage
Authors: Parodi Livia , Comeau Mary E. , Georgakis Marios K. , Mayerhofer Ernst , Chung Jaeyoon , Falcone Guido J. , Malik Rainer , Demel Stacie L. , Worrall Bradford B. , Koch Sebastian , Testai Fernando D. , Kittner Steven J. , McCauley Jacob L. , Hall Christiana E. , Mayson Douglas J. , Elkind Mitchell S.V. , James Michael L. , Woo Daniel , Rosand Jonathan , Langefeld Carl D. , Anderson Christopher D. 
Published: October 2023

ObjectiveGenome‐wide association studies have identified 1q22 as a susceptibility locus for cerebral small vessel diseases, including non‐lobar intracerebral hemorrhage (ICH) and lacunar stroke. In the present study, we performed targeted high‐depth sequencing of 1q22 in ICH cases and controls to further characterize this locus and prioritize potential causal mechanisms, which remain unknown.MethodsA total of 95,000 base pairs spanning 1q22, including SEMA4A, SLC25A44, and PMF1/PMF1‐BGLAP were sequenced in 1,055 spontaneous ICH cases (534 lobar and 521 non‐lobar) and 1,078 controls. Firth regression and Rare Variant Influential Filtering Tool analysis were used to analyze common and rare variants, respectively. Chromatin interaction analyses were performed using Hi‐C, chromatin immunoprecipitation followed by sequencing, and chromatin interaction analysis with paired‐end tag databases. Multivariable Mendelian randomization assessed whether alterations in gene‐specific expression relative to regionally co‐expressed genes at 1q22 could be causally related to ICH risk.ResultsCommon and rare variant analyses prioritized variants in SEMA4A 5′‐UTR and PMF1 intronic regions, overlapping with active promoter and enhancer regions based on ENCODE annotation. Hi‐C data analysis determined that 1q22 is spatially organized in a single chromatin loop, and that the genes therein belong to the same topologically associating domain. Chromatin immunoprecipitation followed by sequencing and chromatin interaction analysis with paired‐end tag data analysis highlighted the presence of long‐range interactions between the SEMA4A‐promoter and PMF1‐enhancer regions prioritized by association testing. Multivariable Mendelian randomization analyses demonstrated that PMF1 overexpression could be causally related to non‐lobar ICH risk.InterpretationAltered promoter–enhancer interactions leading to PMF1 overexpression, potentially dysregulating polyamine catabolism, could explain demonstrated associations with non‐lobar ICH risk at 1q22, offering a potential new target for prevention of ICH and cerebral small vessel disease. ANN NEUROL 2024;95:325–337
Understanding co‐corresponding authorship: A bibliometric analysis and detailed overview
Authors: Tian Wencan , Cai Ruonan , Fang Zhichao , Geng Yu , Wang Xianwen , Hu Zhigang 
Published: October 2023

AbstractThe phenomenon of co‐corresponding authorship is becoming more and more common. To understand the practice of authorship credit sharing among multiple corresponding authors, we comprehensively analyzed the characteristics of the phenomenon of co‐corresponding authorships from the perspectives of countries, disciplines, journals, and articles. This researcher was based on a dataset of nearly 8 million articles indexed in the Web of Science, which provides systematic, cross‐disciplinary, and large‐scale evidence for understanding the phenomenon of co‐corresponding authorship for the first time. Our findings reveal that higher proportions of co‐corresponding authorship exist in Asian countries, especially in China. From the perspective of disciplines, there is a relatively higher proportion of co‐corresponding authorship in the fields of engineering and medicine, while a lower proportion exists in the humanities, social sciences, and computer science fields. From the perspective of journals, high‐quality journals usually have higher proportions of co‐corresponding authorship. At the level of the article, our findings proved that, compared to articles with a single corresponding author, articles with multiple corresponding authors have a significant citation advantage.
Synthesis of Thiophene‐Substituted Ketones via Manganese‐Catalyzed Dehydrogenative Coupling Reaction
Authors: Zhang Xiaoyu , Zhang Yujie , Ding Jiaqiao , Wang Liusheng , Chen Weihua , Li Xinyan , Cui Bing , Zhao Mingqin , Shao Zhihui 
Published: October 2023

AbstractThis study reports an efficient and green one‐step method for synthesizing thiophene‐substituted ketones from 2‐thiophenemethanol and ketones via dehydrogenative coupling using manganese complexes as catalysts. The manganese complex demonstrated a broad applicability under mild conditions and extended the range of usable substrates. Utilizing this strategy, we carried out an efficient and diverse reaction of ketones with 2‐thiophenemethanol, and successfully synthesized a series of thiophene‐substituted saturated ketones and α, β‐unsaturated ketones in good isolated yields.
Reusing wastewater from Coffea arabica processing to produce single‐cell protein using Candida sorboxylosa: Optimizing of culture conditions
Authors: Pillaca‐Pullo Omar Santiago , Lopes André Moreni , Estela‐Escalante Waldir D. 
Published: October 2023

AbstractCoffee is a crop of significant socioeconomic importance, and the reuse of agri‐food by‐products and biowaste has great potential across several industries. Coffee wastewater (CWW) is a valuable resource containing essential nutrients that can be utilized by Candida sorboxylosa for single‐cell protein (SCP) production. This utilization contributes to mitigating the negative impacts of agro‐industrial waste. The optimization of culture conditions using the design of experiments (DoE) technique is crucial in understanding the environmental factors influencing metabolite production. In our study, the DoE technique was employed to analyze culture conditions, including room temperature, pH 8.4, agitation at 200 rpm, a headspace of 60% (v/v), and an inoculum of 0.75 DO600nm over 28‐h period. This approach resulted in a remarkable SCP yield of 64.4% and dry cell weight (DCW) of 2.26 g/L. It is noteworthy that there is no literature reporting SCP production under alkaline pH conditions in yeast. Interestingly, our work demonstrated that an alkaline pH of 8.4 significantly influenced SCP production by C. sorboxylosa. The DoE technique proved to be an efficient statistical tool for optimizing culture conditions, offering several advantages, such as: (i) conducting cultures at room temperature to minimize unnecessary energy consumption; (ii) reducing the incubation time from 46 to 28 h, thereby enhancing overall productivity; (iii) achieving 1.7‐fold increase in SCP yield compared to previous basal production levels.
Applying active learning by contextualizing robotic applications to historical heritage
Authors: Quesada‐Real Francisco J. , Perez‐Peña Fernando , Morgado‐Estévez Arturo , Ruiz‐Lendínez Juan J. 
Published: October 2023

AbstractOptional university courses are designed to allow undergraduate students to specialize in relevant fields to enhance their skills and knowledge for their future careers. However, there are some cases in which students prioritize enrolling in courses that are easy to pass. This choice results in having students with low motivation and commitment, who mainly focus on doing just enough to pass the course, missing the opportunity to boost their skills. In this study, an eclectic approach is proposed, applying a mixture of active learning methods together with the theory of multiple intelligences to improve students' performance, motivation, and commitment throughout the course. The study was applied to the 56 students enrolled in the optional Micro‐Robotics Application spring course in the year 2021 at the University of Cádiz (Spain). Results demonstrate that this combination of active learning methodologies increased students' motivation, prompting them to give their best in terms of commitment, performance, and creativity. Furthermore, they were convinced that during the course they not only learned relevant robotic knowledge but also acquired essential skills needed for their future. Finally, this study highlights the benefits and future directions for implementing active learning methodologies in science, technology, engineering, and mathematics courses.
Molecular Docking, Pharmacokinetic and Molecular Simulation Analysis of Novel Mono‐Carbonyl Curcumin Analogs as L858R/T790M/C797S Mutant EGFR Inhibitors
Authors: Bhandari Shashikant V. , Kuthe Pranali V. , Patil Shital M. , Nagras Om G. , Sarkate Aniket P. , Chaudhari Somdatta Y. , Surve Sandip V. 
Published: October 2023

AbstractIntroduction: Curcumin, an anticancer natural compound with multiple pharmacological activities, has a weak pharmacokinetic and instability due to diketone moiety. Curcumin's stability challenges can be overcome by removing the diketone moiety and shortening the 7‐carbon chain, resulting in mono‐carbonyl analogs. Cancer proliferation is caused by the activation of Epidermal Growth Factor (EGFR) pathways. Current available EGFR inhibitors have an issue of resistance. Aim: Thus, we aimed to design new mono‐carbonyl curcumin derivatives and analyse their drug likeness properties. Further, to investigate them on three distinct crystal structures, namely two wild‐type and L858R/T790M/C797S mutant generations for EGFR inhibitory activity. Method: Ten New Molecular Entities (NME's) were designed using literature survey. These molecules were subjected to comparative molecular docking, on the EGFR crystal structures viz. wild‐type (PDB: 1M17 and 4I23) and L858R/T790M/C797S mutant (PDB: 6LUD) using Schrodinger software. The molecules were also tested for Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties. The docked complex of the hit molecule was studied for molecular simulation. Result and Discussion: In molecular docking studies, NMEs 1, 2, and 3 were found to have good binding affinity with 1st, 2nd, and 3rd generation EGFR crystal structures and a greater dock score than standard curcumin. All molecules have shown a good ADMET profile. Since L858R/T790M/C797S is currently being explored more, we decided to take the best molecule, NME 3, for molecular dynamics with 6LUD, and the results were compared with those of the co‐crystallized ligand S4 (Osimertinib). It was found that the Relative mean square standard deviation (RMSD) (1.8 Å), Relative mean standard Fluctuation (RMSF) (1.45 Å) and radius of gyration (4.87 Å) values of NME 3 were much lower than those of reference S4. All these confirm that our designed NME 3 is more stable than reference S4. Conclusion: NME 1 and NME 2 have shown better binding against wild type of EGFR. NME 3 have shown comparable binding and more stability as compared to Osimertinib against L858R/T790M/C797S mutated protein structure. The hit compound can be further explored for its Molecular mechanics with generalised Born and surface area solvation (MM‐GBSA) and discrete Fourier transform (DFT) studies to find out the energy and atomic level study. In the future, this molecule could be taken for wet lab studies and can be tested for mutated EGFR inhibitory activity.
HER‐2‐Targeted Boron Neutron Capture Therapy with Carborane‐integrated Immunoliposomes Prepared via an Exchanging Reaction
Authors: Kawasaki Riku , Oshige Ayano , Yamana Keita , Hirano Hidetoshi , Nishimura Kotaro , Miura Yamato , Yorioka Ryuji , Sanada Yu , Bando Kaori , Tabata Anri , Yasuhara Kazuma , Miyazaki Yusuke , Shinoda Wataru , Nishimura Tomoki , Azuma Hideki , Takata Takushi , Sakurai Yoshinori , Tanaka Hiroki , Suzuki Minoru , Nagasaki Takeshi , Ikeda Atsushi 
Published: October 2023

AbstractBoron neutron capture therapy (BNCT) is a promising modality for cancer treatment because of its minimal invasiveness. To maximize the therapeutic benefits of BNCT, the development of efficient platforms for the delivery of boron agents is indispensable. Here, carborane‐integrated immunoliposomes were prepared via an exchanging reaction to achieve HER‐2‐targeted BNCT. The conjugation of an anti‐HER‐2 antibody to carborane‐integrated liposomes successfully endowed these liposomes with targeting properties toward HER‐2‐overexpressing human ovarian cancer cells (SK‐OV3); the resulting BNCT activity toward SK‐OV3 cells obtained using the current immunoliposomal system was 14‐fold that of the l‐BPA/fructose complex, which is a clinically available boron agent. Moreover, the growth of spheroids treated with this system followed by thermal neutron irradiation was significantly suppressed compared with treatment with the l‐BPA/fructose complex.