bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving outcomes for poorly responding clients: The use of clinical support tools and feedback to clients
Authors: Harmon Cory , Hawkins Eric J. , Lambert Michael J. , Slade Karstin , Whipple Jason S. 
Published: December 2004

AbstractWe present two methods of enhancing outcome and preventing treatment failure in psychotherapy. The first involves providing therapists with a decision tree and several assessment measures for clients who are not having a positive response to psychotherapy. The organization of the decision tree and the selection of measures were based on results from psychotherapy outcome studies. The second method involves providing clients with feedback on their progress throughout the course of treatment. Both methods of providing feedback enhanced treatment outcomes and representative studies are reviewed. Use of these methods is recommended for application in routine practice. © 2004 Wiley Periodicals, Inc. J Clin Psychol/In Session.
Implementation of a feedback system in a managed care environment: What are patients teaching us?
Authors: Brown George S. , Jones Edward R. 
Published: December 2004

AbstractLessons about patient treatment response from a large‐scale outcomes management project are summarized. More than 7,000 clinicians contributed outcome data. Overall, the data demonstrated that patients who have clinical levels of psychological distress and impairment showed a relatively rapid response to treatment. Furthermore, although it appears that the duration and intensity of treatment vary widely from case to case, clinicians and patients make sound judgments as to how much and what kind of treatment is appropriate. Results supported the conclusion that the most effective method to manage costs is to ensure that each patient receive effective care. There are large and stable differences in the effectiveness of clinicians, and outcomes can be improved by referring patients to effective clinicians. The data also suggested that patients who had a poor initial response to treatment eventually had positive outcomes, provided that they remained engaged in treatment. This finding suggests that outcomes can be improved by identifying at‐risk patients and proactively keeping them engaged in treatment. © 2004 Wiley Periodicals, Inc. J Clin Psychol/In Session.
Effect of the promoter and support on the catalytic activity of PdCeO2‐supported catalysts for CH4 combustion
Authors: Pecchi G , Reyes P , Zamora R , López T , Gómez R 
Published: December 2004

AbstractA series of palladium–ceria‐supported catalysts prepared by the sol–gel method are characterized and their catalytic results are reported. It was found that the addition of ceria to alumina produces a highly dispersed catalyst when compared with their zirconia counterparts. However, the catalytic activity of the ceria zirconia series is higher, essentially due to the larger particle size of palladium. This result can be attributed to the structure‐sensitive reaction of the combustion of methane. Copyright © 2004 Society of Chemical Industry
Extremal solutions for nonlinear second order differential inclusions
Authors: Douka P. , Papageorgiou N. S. 
Published: December 2004

AbstractWe consider a nonlinear second order differential inclusion driven by the scalar p‐Laplacian and with nonlinear multivalued boundary conditions. Assuming the existence of an ordered pair of upper‐lower solutions and using truncation and penalization techniques together with Zorn's lemma, we show that the problem has extremal solutions in the order interval formed by the upper und lower solutions. We present some special cases of interest and show that our method applies also to the periodic problem. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Hurwitz spaces of quadruple coverings of elliptic curves and the modulispace of abelian threefolds 𝒜3(1, 1, 4)
Authors: Kanev Vassil 
Published: December 2004

AbstractWe prove that the moduli space 𝒜3(1, 1, 4) of polarized abelian threefolds with polarization of type (1, 1, 4) is unirational. By a result of Birkenhake and Lange this implies the unirationality of the isomorphic moduli space 𝒜3(1, 4, 4). The result is based on the study the Hurwitz space ℋ︁4,n(Y) of quadruple coverings of an elliptic curve Y simply branched in n ≥ 2 points. We prove the unirationality of its codimension one subvariety ℋ︁04,A(Y) which parametrizes quadruple coverings π : X → Y with Tschirnhausen modules isomorphic to A–1, where A ∈ Picn/2Y, and for which π* : J(Y) → J(X) is injective. This is an analog of the result of Arbarello and Cornalba that the Hurwitz space ℋ︁4,n(ℙ1) is unirational. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Elliptic problems for the Dolbeault complex
Authors: Kytmanov A. , Myslivets S. , Schulze B.‐W. , Tarkhanov N. 
Published: December 2004

AbstractThe inhomogeneous$ \overline \partial $‐equation is an inexhaustible source of locally unsolvable equations, subelliptic estimates and other phenomena in partial differential equations. Loosely speaking, for the analysis on complex manifolds with boundary nonelliptic problems are typical rather than elliptic ones. Using explicit integral representations we assign a Fredholm complex to the Dolbeault complex over an arbitrary bounded domain in ℂn. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Wavelet bases and entropy numbers in weighted function spaces
Authors: Haroske Dorothee D. , Triebel Hans 
Published: December 2004

AbstractThe aim of this paper is twofold. First we prove that inhomogeneous wavelets of Daubechies type are unconditional Schauder bases in weighted function spaces of Bspq and Fspq type. Secondly we use these results to estimate entropy numbers of compact embeddings between these spaces. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Vorticity–vector potential formulations of the Stokes equations in the half‐space
Authors: Boulmezaoud Tahar Zamène , Medjden Mohamed 
Published: December 2004

AbstractSUMMARYThe main objective of this paper is to propose two vorticity–vector potential formulations of the Stokes problem in the half space of ℝ3. Weighted spaces are used for describing the behaviour at large distances.RÉSUMÉOn propose deux formulations de type vorticité–potentiel vecteur du problème de Stokes dans le demi‐espace de ℝ3. Les espaces de Sobolev avec poids sont utilisés pour décrire le comportement des fonctions à l'infini. Copyright © 2004 John Wiley & Sons, Ltd.
Piperidone derivative from Dalbergia sympathetica
Authors: Shanmugam Nagarajan N. , Priya Rao R , Narayanan Manoj C. , Gopalakrishnan Sethuraman M. 
Published: December 2004

AbstractAn alcoholic extract of Dalbergia sympathetica, on column chromatography, yielded a compound which analyzed for C6H11NO3 (M+ 145). The IR spectrum of the compound showed the presence of carbonyl and hydroxyl groups. PMR, 13C and DEPT NMR spectral studies of the compound showed the presence of one N‐methyl, two methine and two methylene groups. A quaternary carbon signal at δ 172.88 ppm was assigned to C‐2 carbonyl of the compound. From all the above observations and also from the HMQC 2D NMR spectrum, the compound was identified as 3, 6‐dihydroxy‐N‐methyl‐2‐piperidone. This is the first report of the natural occurrence of this compound from plant sources. Copyright © 2004 John Wiley & Sons, Ltd.
Synthesis and complete 1H, 13C and 15N NMR assignment of substituted isoxazolo[3,4‐d]pyridazin‐7(6H)‐ones
Authors: Dal Piaz V. , Graziano A. , Haider N. , Holzer W. 
Published: December 2004

AbstractThe synthesis and complete assignment of all hydrogen, carbon and nitrogen NMR signals of several new isoxazolo[3,4‐d]pyridazin‐7(6H)‐ones is reported. The spectroscopic characterization is extended to previously described analogues. Copyright © 2004 John Wiley & Sons, Ltd.
195Pt, 1H and 31P PGSE diffusion studies on platinum complexes
Authors: Nama Devendrababu , Anil Kumar P. G. , Pregosin Paul S. 
Published: December 2004

AbstractThe first example of the use of 195Pt PGSE diffusion data (D values) to recognize the solvent dependence of aggregation of the hexachloroplatinate dianion in Na2PtCl6 (1) and in H2PtCl6 (2) is reported. In water, the ions are separated; however, in methanol the D values suggest ion pairing and/or aggregation. Additional 1H and 31P diffusion data for organometallic Pt complexes trans‐PtX(Aryl)(L)2 (where L = PEt3 or PPh3) and Pt(C7H4O2)(L1)(L2) (where L1 and L2 = a variety of ligand types) reveal that phenyl phosphines afford relatively large hydrodynamic radii rh. The presence of a substituent on the aryl ligand of PtX(Aryl)(L)2 does not markedly affect the D values, whereas a substituent of similar size added to a PPh3 group in Pt(C7H4O2)(L1)(L2) markedly changes both D and rh values. There is only a small concentration dependence of the D values in PtX(Aryl)(L)2 on changing from 2 to 10 mM. Copyright © 2004 John Wiley & Sons, Ltd.
Excitability differences in lower‐limb motor axons during and after ischemia
Authors: Krishnan Arun V. , Lin Cindy S.‐Y. , Kiernan Matthew C. 
Published: December 2004

AbstractNeuropathic diseases typically begin distally and spread proximally. Irrespective of the etiology, pathological investigations often indicate changes consistent with ischemia. In the present study, threshold tracking was used to investigate length‐dependent differences in ischemic susceptibility of lower‐limb axons in 6 healthy volunteers, with ischemia induced by a sphygmomanometer cuff inflated to 200 mm Hg and maintained for 13 minutes. Following stimulation of the peroneal nerve at the fibula neck, compound muscle action potentials were recorded proximally from tibialis anterior (TA) and distally from extensor digitorum brevis (EDB). During ischemia, excitability changes were consistent with nerve depolarization, with a greater reduction in threshold in EDB than TA. This reduction in threshold was associated with an increase in refractoriness, decrease in superexcitability, and prolongation of strength–duration time constant, consistent with axonal depolarization. With release of ischemia, reversal of these changes was associated with an increase in threshold, greater in EDB than TA, indicating axonal hyperpolarization. The rate of recovery of threshold was similar proximally and distally, arguing against a gradient in Na+/K+ pump function along the peroneal nerve. The greater changes in threshold in EDB during and after ischemia suggest an increased susceptibility of more distal axons to ischemia and are likely to contribute to the length‐dependent development of neuropathy. Muscle Nerve, 2005
Ab initio prediction of the three‐dimensional structure of a de novo designed protein: A double‐blind case study
Authors: Klepeis John L. , Wei Yinan , Hecht Michael H. , Floudas Christodoulos A. 
Published: December 2004

AbstractAb initio structure prediction and de novo protein design are two problems at the forefront of research in the fields of structural biology and chemistry. The goal of ab initio structure prediction of proteins is to correctly characterize the 3D structure of a protein using only the amino acid sequence as input. De novo protein design involves the production of novel protein sequences that adopt a desired fold. In this work, the results of a double‐blind study are presented in which a new ab initio method was successfully used to predict the 3D structure of a protein designed through an experimental approach using binary patterned combinatorial libraries of de novo sequences. The predicted structure, which was produced before the experimental structure was known and without consideration of the design goals, and the final NMR analysis both characterize this protein as a 4‐helix bundle. The similarity of these structures is evidenced by both small RMSD values between the coordinates of the two structures and a detailed analysis of the helical packing. Proteins 2005. © 2004 Wiley‐Liss, Inc.
Water dynamics simulation as a tool for probing proton transfer pathways in a heptahelical membrane protein
Authors: Kandt Christian , Gerwert Klaus , Schlitter Jürgen 
Published: December 2004

AbstractThe proton transfer pathway in a heptahelical membrane protein, the light‐driven proton pump bacteriorhodopsin (BR), is probed by a combined approach of structural analysis of recent X‐ray models and molecular dynamics (MD) simulations that provide the diffusion pathways of internal and external water molecules. Analyzing the hydrogen‐bond contact frequencies of the water molecules with protein groups, the complete proton pathway through the protein is probed. Beside the well‐known proton binding sites in the protein interior—the protonated Schiff base, Asp85 and Asp96, and the H5O complex stabilized by Glu204 and Glu194—the proton release and uptake pathways to the protein surfaces are described in great detail. Further residues were identified, by mutation of which the proposed pathways can be verified. In addition the diffusion pathway of water 502 from Lys216 to Asp96 is shown to cover the positions of the intruding waters 503 and 504 in the N‐intermediate. The transiently established water chain in the N‐state provides a proton pathway from Asp96 to the Schiff base in the M‐ to N‐transition in a Grotthus‐like mechanism, as concluded earlier from time‐resolved Fourier transform infrared experiments [le Coutre et al., Proc Nat Acad Sci USA 1995;92:4962–4966]. Proteins 2005. © 2004 Wiley‐Liss, Inc.
Synthesis of spiroketal enol ethers related to tonghaosu and their insecticidal activities
Authors: Chen Li , Xu Han‐Hong , Hu Tai‐Shan , Wu Yu‐Lin 
Published: December 2004

AbstractThis paper describes the syntheses and biological activities of a number of spiroketal enol ethers which are analogues of the plant extract tonghaosu. The insecticidal potential of this spiroketal system is assessed. Copyright © 2005 Society of Chemical Industry
Protein open‐access liquid chromatography/mass spectrometry
Authors: White Wendy L. , Wagner Craig D. , Hall John T. , Chaney Erin E. , George Bindu , Hofmann Karen , Miller Luke A. D. , Williams Jon D. 
Published: December 2004

AbstractEach year increasing numbers of proteins are submitted for routine characterization by liquid chromatography/mass spectrometry (LC/MS). This paper reports a solution that transforms routine LC/MS analysis of proteins into a fully automated process that significantly reduces analyst intervention. The solution developed, protein open‐access (OA) LC/MS, consists of web‐enabled sample submission and registration, automated data processing, data interpretation, and report generation. Sample submissions and results are recorded in a LIMS that utilizes an Oracle database. The protein sequence is captured during the sample submission process, stored in the database, and utilized to determine the theoretical protein molecular weight. This calculated mass is used to set the parameters for transformation of the mass‐to‐charge spectra to the mass domain and evaluate the presence or absence of the desired protein. Three protein OA‐LC/MS instruments have been deployed in our facility to support protein characterization, purification, and modification efforts. Copyright © 2004 John Wiley & Sons, Ltd.
Oxidized carbon nanotubes as matrix for matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometric analysis of biomolecules
Authors: Ren Shi‐fang , Guo Yin‐long 
Published: December 2004

AbstractOxidized carbon nanotubes (CNTs), which can form a stable homogeneous suspension in water close to a solution phase, were synthesized and used for matrix‐assisted desorption/ionization mass spectrometric (MALDI‐MS) analysis of biomolecules. Infrared (IR) spectra, transmission electron microscopy (TEM) and particle size analysis were used for the characterization of the oxidized CNTs. The results indicate that the physical structure of the CNTs was not damaged, but carboxylate groups were introduced onto the surface of the CNTs. In addition, impurities including amorphous carbon, which is one of the main reasons for ion source contamination, were destroyed by the oxidization. The carboxyl groups on the oxidized surface of the CNTs can not only provide an additional proton source, but can also increase the surface polarity and solubility of the CNTs, making it easier to manipulate which is important for MALDI analysis of some biomolecules, especially larger peptides and proteins. The oxidized CNTs were successfully applied to the analysis of neutral oligosaccharides, peptides, and insulin, and thus promise to be an efficient matrix for MALDI‐MS analysis of biomolecules. Copyright © 2004 John Wiley & Sons, Ltd.
Using a simple high‐performance liquid chromatography separation and fraction collection methodology to achieve compound‐specific isotopic analysis for dissolved organic compounds
Authors: Marschner Mark , Middlestead Paul , Clark Ian D. 
Published: December 2004

AbstractA new application for the quantitative and isotopic analyses of dissolved inorganic and dissolved organic carbon compounds has been developed. Dissolved organic matter (DOM) in natural water samples can be separated on a high‐performance liquid chromatography (HPLC) column and collected as fractions. Each discrete fraction can then be analyzed using the technique of St‐Jean (Rapid Commun. Mass Spectrom. 2003; 17: 419–428) with a total inorganic carbon/total organic carbon (TIC/TOC) analyzer interfaced with a continuous‐flow isotope ratio mass spectrometer. Experimental data using short‐chain fatty acid standards (formic, acetic, and propionic acids) show that fraction recoveries of 100% are possible and that sample integrity is maintained. 13C‐isotopic analyses of products prior to and subsequent to extraction and collection show no isotopic effects associated with the methodology, and errors are well within the accepted analytical uncertainty of the IRMS. Comparison of data from pure standards and organic‐rich natural waters shows that quantitative analyses still need to be done with standards that more closely imitate the matrices of the samples, in order to acquire an appropriate calibration curve. Injections of organic‐rich matrices on the HPLC column did not affect fraction recovery, nor did they create high background of partially retained organic compounds slowly released from the HPLC column, and hence 13C‐isotopic results are relatively unaffected. The specific limitation on this methodology is the required use of carbon‐free carrier solvents due to potential memory effects associated with the TIC/TOC analyzer. Further developments of this application could make routine compound‐specific isotopic analyses (CSIA) for a wider range of organic materials possible. Copyright © 2004 John Wiley & Sons, Ltd.
Effects of reduced endogenous 5‐HT on the in vivo binding of the serotonin transporter radioligand 11C‐DASB in healthy humans
Authors: Talbot Peter S. , Frankle W. Gordon , Hwang Dah‐Ren , Huang Yiyun , Suckow Raymond F. , Slifstein Mark , Abi‐Dargham Anissa , Laruelle Marc 
Published: December 2004

AbstractAlthough abnormal serotonin (5‐HT) function is implicated in a range of mental disorders, there is currently no method to directly assess 5‐HT synaptic levels in the living human brain. The in vivo binding of some dopamine (DA) radioligands such as 11C‐raclopride is affected by fluctuations in endogenous DA, thus providing an indirect measure of DA presynaptic activity. Attempts to identify a serotonergic radiotracer with similar properties have proved unsuccessful. Here, we investigated in humans the effects of reduced synaptic 5‐HT on the in vivo binding of the 5‐HT transporter (SERT) radioligand 11C‐DASB, using Positron Emission Tomography (PET) and the rapid tryptophan depletion (RTD) technique. Eight (8) subjects (5M, 3F) were scanned with 11C‐DASB under control and reduced endogenous 5‐HT conditions, in a within‐subject, double‐blind, counterbalanced, crossover design. Regional distribution volumes (VT) were calculated using kinetic modeling and metabolite‐corrected arterial input function. 11C‐DASB specific binding was estimated as binding potential (BP) and specific to nonspecific equilibrium partition coefficient (V), using the cerebellum as reference region. RTD caused small but significant mean reductions in 11C‐DASB VT (−6.1%) and BP (−4.5%) across brain regions, probably explained by a concomitant reduction in 11C‐DASB plasma free fraction (f1) of similar magnitude. No significant change in 11C‐DASB V was observed between control and reduced 5‐HT conditions. Nor was there a significant relationship between the magnitude of tryptophan depletion and change in BP and V across individual subjects. These results suggest that 11C‐DASB in vivo binding is not affected by reductions in endogenous 5‐HT. Synapse 55:164–175, 2005. © 2004 Wiley‐Liss, Inc.
Getting down to business: Defining competencies for entry‐level youth workers
Authors: Astroth Kirk A. , Garza Pam , Taylor Barbara 
Published: December 2004

AbstractIn January 2004, the National Collaboration for Youth approved a list of core competencies needed by entry‐level youth development workers for effective youth development practice. This chapter provides an overview of these competencies, explaining why and how the list was created, outcomes, and recommendations for next steps.
Achieve Boston: A citywide innovation in professional development
Authors: Barbosa Moacir , Gannett Ellen S. , Goldman Jude , Wechsler Samantha , Noam Gil G. 
Published: December 2004

AbstractAchieve Boston is a broad‐based collaborative effort to improve the overall quality of programs for children and youth by establishing a professional development infrastructure that supports those who work with young people during the out‐of‐school‐time hours.
The intermediary role in youth worker professional development: Successes and challenges
Authors: Johnson Elaine , Rothstein Fran , Gajdosik Jennifer 
Published: December 2004

AbstractThis chapter examines the role of a national network of local and regional intermediary organizations in initiating and sustaining community‐based youth worker professional development systems. This approach is instructive for other intermediaries in establishing training standards, assessing impact, providing organizational supports for youth development workers, and going to scale.
Synthesis and Characterization of a Molecular Zinc Phosphate Ni(2, 2'‐bipy)3·[ZnCl(H2PO4)3]
Authors: Lin Zhi‐En , Zhang Jie , Zheng Shou‐Tian , Yang Guo‐Yu 
Published: December 2004

AbstractA new zinc phosphate cluster Ni(2, 2'‐bipy)3 · [ZnCl(H2PO4)3] (1) was obtained by the hydrothermal reaction of ZnO, H3PO4, NiCl2·6H2O, 2, 2'‐bipyridine(2, 2'‐bipy) and H2O in a molar ration of 1 : 1.9 : 0.5 : 1.5 : 126. The structure of 1 is made of [ZnCl(H2PO4)3] clusters that are separated by nickel complexes. The compound is novel in the sense that it is the first zinc phosphate cluster with metal complexes acting as structure‐directing agents. Crystal data: trigonal, space group = R3¯c (no. 167), a = 13.2407(3), c = 74.034(3) Å, V = 11240.5(6) Å3, Z = 12.