bluuebunny/crossref_metadata_2025_split huggingface dataset:
The contribution of European citizen‐led energy initiatives to sustainable development goals
Authors: Schwanitz Valeria Jana , Paudler Heather Arghandeh , Wierling August 
Published: December 2023

AbstractEnergy communities (ECs) are emerging as vital contributors to the United Nations' Sustainable Development Goals, despite being unnoticed. This article is the first to comprehensively discuss and quantify European citizen‐led energy initiatives' contributions to SDGs 7 (ensure access to affordable and clean energy), 9 (fostering industry, innovation, and infrastructure), and 11 (promote sustainable cities and communities). With SDG7 at their core, these initiatives prioritize sustainable energy systems, aligning with environmental impact reduction, resource efficiency, and social resilience goals. They contribute to SDG9 in energy and ICT sectors through job creation and social and technological innovation. Promoting SDG11 via inclusive engagement, they reinforce democratic principles and preserve cultural heritage. They can leverage their expertise with policy support to aid SDG implementation and serve as a global exemplar, extending impact to SDGs 12 and 17. Our analysis underscores a disconnect between European support for ECs and broader sustainability agendas, hampering effective impact.
A Visual, In‐Expensive, and Wireless Capillary Rheometer for Characterizing Wholly‐Cellular Bioinks
Authors: Du Jianyi , Lee Stacey , Sinha Soham , Solberg Fredrik S. , Ho Debbie L. L. , Sampson Joshua P. , Wang Qiuling , Tam Tony , Skylar‐Scott Mark A. 
Published: December 2023

AbstractRheological measurements with in situ visualization can elucidate the microstructural origin of complex flow behaviors of an ink. However, existing commercial rheometers suffer from high costs, the need for dedicated facilities for microfabrication, a lack of design flexibility, and cabling that complicates operation in sterile or enclosed environments. To address these limitations, a low‐cost ($300) visual, in‐expensive and wireless rheometer (VIEWR) using 3D‐printed and off‐the‐shelf components is presented. VIEWR measurements are validated by steady‐state and transient flow responses for different complex fluids, and microstructural flow profiles and evolution of yield‐planes are revealed via particle image velocimetry. Using the VIEWR, a wholly‐cellular bioink system comprised of compacted cell aggregates is characterized, and complex yield‐stress and viscoelastic responses are captured via concomitantly visualizing the spatiotemporal evolution of aggregate morphology. A symmetric hyperbolic extensional‐flow geometry is further constructed inside a capillary tube using digital light processing. Such geometries allow for measuring the extensional viscosity at varying deformation rates and further visualizing the alignment and stretching of aggregates under external flow. Synchronized but asymmetric evolution of aggregate orientation and strain through the neck is visualized. Using varying geometries, the jamming and viscoelastic deformation of aggregates are shown to contribute to the extensional viscosity of the wholly‐cellular bioinks.
Construction of Medusa‐Like Adhesive Carbon Nanotube Array Induced by Deformation of Alumina Sheets
Authors: Zhang Kai , Chen Kebei , Di Jiangtao , Gong Wenbin , Li Zhuo , Zhang Jin , Yao Yagang 
Published: December 2023

AbstractTo change the binary structure of nanotube and nanotube array in vertically aligned carbon nanotube arrays, this work deposits regularly arranged amorphous alumina sheets on the classical array growth catalyst (10 nm‐thick alumina and 2 nm‐thick iron) and obtains an array similar to the Medusa head. Subsequent experiments revealed that these alumina sheets show both unstable and stable qualities during growth: unstable in that they thermally deform and change their newly discovered characteristics of blocking carbon source diffusion, which regulates the nanotube growth order in specific areas; stable in that they withstand the deformation caused by heat and sequential growth of nanotubes, serving as a substrate and buffer layer for Medusa's hair, i.e., nanotube bundles on the array surface. Their combination splits this binary structure into a tertiary architecture consisting of nanotubes, nanotube bundles, and the array spanning nano‐, micro‐, and milli‐meter. Benefiting from this structure, this array exhibits a unique near‐isotropic adhesion characteristic compared to existing reports and outperforms classical and patterned arrays with the same classical catalyst and growth conditions.
Programmable Gravity Self‐Driven Microfluidic Chip for Point‐of‐Care Multiplied Immunoassays
Authors: Yuan Huijuan , Wan Chao , Wang Xin , Li Shunji , Xie Han , Qian Chungen , Du Wei , Feng Xiaojun , Li Yiwei , Chen Peng , Liu Bi‐Feng 
Published: December 2023

AbstractPoint‐of‐care testing (POCT) is experiencing a groundbreaking transformation with microfluidic chips, which offer precise fluid control and manipulation at the microscale. Nevertheless, chip design or operation for existing platforms is rather cumbersome, with some even heavily depending on external drivers or devices, impeding their broader utilization. This study develops a unique programmable gravity self‐driven microfluidic chip (PGSMC) capable of simultaneous multi‐reagent sequential release, multi‐target analysis, and multi‐chip operation. All necessary reagents are introduced in a single step, and the process is initiated simply by flipping the PGSMC vertically, eliminating the need for additional steps or devices. Additionally, it demonstrates successful immunoassays in less than 60 min for antinuclear antibodies testing, compared to more than 120 min by traditional methods. Assessment using 25 clinically diagnosed cases showcases remarkable sensitivity (96%), specificity (100%), and accuracy (99%). These outcomes underscored its potential as a promising platform for POCT with high accuracy, speed, and reliability, highlighting its capability for automated fluid control.
Somatosensory Electro‐Thermal Actuator through the Laser‐Induced Graphene Technology
Authors: Wang Hao , Li Xuyang , Wang Xiaoyue , Qin Yong , Pan Yang , Guo Xiaogang 
Published: December 2023

AbstractThe biological system realizes the unity of action and perception through the muscle tissue and nervous system. Correspondingly, artificial soft actuators realize the unity of sensing and actuating functions in a single functional material, which will have tremendous potential for developing intelligent and bionic soft robotics. This paper reports the design of a laser‐induced graphene (LIG) electrothermal actuator with self‐sensing capability. LIG, a functional material formed by a one‐step direct‐write lasing procedure under ambient air, is used as electrothermal conversion materials and piezoresistive sensing materials. By transferring LIG to a flexible silicone substrate, the design ability of the LIG‐based actuator unit is enriched, along with an effectively improved sensing sensitivity. Through the integration of different types of well‐designed LIG‐based actuator units, the transformations from multidimensional precursors to 2D and 3D structures are realized. According to the piezoresistive effect of the LIG units during the deformation process, the visual synchronous deformation state feedback of the LIG‐based actuator is proposed. The multimodal crawling soft robotics and the switchable electromagnetic shielding cloak serve as the demonstrations of the self‐sensing LIG‐based actuator, showing the advantage of the design in remote control of the soft robot without relying on the assistance of visual devices.
Ti‐Modified Imogolite Nanotubes as Promising Photocatalyst 1D Nanostructures for H2 Production
Authors: Jimenéz‐Calvo Pablo , Naciri Yassine , Sobolewska Anna , Isaacs Mark , Zhang Yu , Leforestier Amélie , Degrouard Jéril , Rouzière Stéphan , Goldmann Claire , Vantelon Delphine , Hettler Simon , Zaluzec Nestor J. , Arenal Raul , Launois Pascale , Ghazzal Mohamed Nawfal , Paineau Erwan 
Published: December 2023

AbstractImogolite nanotubes (INTs) are predicted as a unique 1D material with spatial separation of conduction and valence band edges but their large band gaps have inhibited their use as photocatalysts. The first step toward using these NTs in photocatalysis and exploiting the polarization‐promoted charge separation across their walls is to reduce their band gap. Here, the modification of double‐walled aluminogermanate INTs by incorporation of titanium into the NT walls is explored. The precursor ratio x = [Ti]/([Ge]+[Ti]) is modulated between 0 and 1. Structural and optical properties are determined at different scales and the photocatalytic performance is evaluated for H2 production. Although the incorporation of Ti atoms into the structure remains limited, the optimal condition is found around x = 0.4 for which the resulting NTs reveal a remarkable hydrogen production of ≈1500 µmol g−1 after 5 h for a noble metal‐free photocatalyst, a 65‐fold increase relative to a commercial TiO2‐P25. This is correlated to a lowering of the recombination rate of photogenerated charge carriers for the most active structures. These results confirm the theoretical predictions regarding the potential of modified INTs as photoactive nanoreactors and pave the way for investigating and exploiting their polarization properties for energy applications.
Comprehensive analyses and experimental verification of NETs and an EMT gene signature for prognostic prediction, immunotherapy, and chemotherapy in pancreatic adenocarcinoma
Authors: Zhang Jing , Wang Chaochen , Yu Yaqun 
Published: December 2023

AbstractPancreatic adenocarcinoma (PAAD) is an aggressive malignancy with high mortality and poor prognosis. Neutrophil extracellular traps (NETs) and the epithelial‐mesenchymal transition (EMT) significantly influence on the progression of various cancers. However, the underlying relevance of NETs‐ and EMT‐associated genes on the outcomes of patients with PAAD remains to be elucidated. Transcriptome RNA sequencing data, together with clinical information and single‐cell sequencing data of PAAD were collected from public databases. In the TCGA‐PAAD cohort, ssGSEA was used to calculate NET and EMT scores. WGCNA was used to determine the key gene modules. A risk model with eight NET‐ and EMT‐related genes (NERGs) was established using LASSO and multivariate Cox regression analysis. Patients in the reduced risk (RR) group showed better prognostic values compared with those in the elevated risk (ER) group. The prognostic model exhibited reliable and robust prediction when validated using an external database. The distributions of risk genes were explored in a single‐cell sequencing data set. Immune infiltration, immune cycle, and immune checkpoints were compared between the RR and ER groups. Moreover, potential chemotherapeutic drugs were examined. DCBLD2 was identified as a key gene in PAAD cell lines by qRT‐PCR, and was highly expressed in PAAD tissues. GSEA demonstrated that DCBLD2 induced the EMT. Transwell assays and western blotting showed that cell invasion and EMT induction were significantly reduced after DCBLD2 knockdown. Collectively, we constructed a prognosis model based on a NET and EMT gene signature, providing a valuable perspective for the prognostic evaluation and management of PAAD patient.
The Cheeger cut and Cheeger problem in metric measure spaces
Authors: Mazón José M. 
Published: December 2023

AbstractIn this paper we study the Cheeger cut and Cheeger problem in the general framework of metric measure spaces. A central motivation for developing our results has been the desire to unify the assumptions and methods employed in various specific spaces, such as Riemannian manifolds, Heisenberg groups, graphs, etc. We obtain two characterization of the Cheeger constant: a variational one and another one through the eigenvalue of the 1-Laplacian. We obtain a Cheeger inequality along the lines of the classical one for Riemannian manifolds obtained by Cheeger in (In: Gunning RC (ed) Problems in analysis. Princeton University Press, Princeton, pp 195–199, 1970). We also study the Cheeger problem. Through a variational characterization of the Cheeger sets we prove the existence of Cheeger sets and obtain a characterization of the calibrable sets and a version of the Max Flow Min Cut Theorem.
Capacitive spectroscopy as transduction mechanism for wearable biosensors: opportunities and challenges
Authors: Díaz-Fernández Ana , de-los-Santos-Álvarez Noemí , Lobo-Castañón María Jesús 
Published: December 2023

AbstractWearable sensors would revolutionize healthcare and personalized medicine by providing individuals with continuous and real-time data about their bodies and environments. Their integration into everyday life has the potential to enhance well-being, improve healthcare outcomes, and offer new opportunities for research. Capacitive sensors technology has great potential to enrich wearable devices, extending their use to more accurate physiological indicators. On the basis of capacitive sensors developed so far to monitor physical parameters, and taking into account the advances in capacitive biosensors, this work discusses the benefits of this type of transduction to design wearables for the monitoring of biomolecules. Moreover, it provides insights into the challenges that must be overcome to take advantage of capacitive transduction in wearable sensors for health.
Graphical abstract
Lophelia reefs off North and West Africa–Comparing environment and health
Authors: Buhl-Mortensen L. , Houssa R. , M’bengue B. , Nyadjro E. S. , Cervantes D. , Idrissi M. , Mahu E. , Dia A. S. , Olsen M. , Mas C. , Chierici M. 
Published: December 2023

AbstractThe health status of cold-water coral reefs on the West African coast was investigated with the main objective of obtaining knowledge of the adaptive capacity ofLophelia pertusato environmental stressors. Three coral sites were studied, in Northern Morocco, in the Morocco/Mauritania region (both in 2020) and, in the Ghana and Ivory coast region (visited in 2012, 2017, and 2019). Area cover of live colonies, explored through underwater videos, was used as an indicator of reef health and compared with the environmental variables: reef position, depth, water mass, temperature, dissolved oxygen concentration (DO), carbonate chemistry (pH, aragonite saturation (ΩAr), macronutrients and particles (visual). For a broader picture of the adaptations presented byLopheliaour results were compared with reefs in contrasting environments. Off Ghana and Mauritania healthy reefs (i.e., having areas with more than 20 % cover of live colonies) were found to reside at DO concentrations between 1.1 and 1.6 ml L−1, in corrosive waters (pH 7.7 and ΩAr 1.0) with high nutrient concentrations. By contrast, the reefs off the North of Morocco, sitting in well-oxygenated waters with oversaturated ΩAr, had no or few live colonies. Our findings together with data from other studies show thatLopheliahas a wide tolerance to hypoxia and acidification, and that in relation to climate change increased temperature and silting could pose more serious threats. These findings highlight the importance of continued studies ofLopheliareefs in contrasting environmental conditions to better understand their adaptation potential to climate change-related stressors.
Quality of Life in the Danish Fontan Population is Unchanged Over the Past Decade—A Nationwide Longitudinal Study
Authors: Ravndal Maren , Kelly Benjamin , Ekholm Ola , Andersen Helle , Nielsen Dorte Guldbrand , Idorn Lars , Hjortdal Vibeke 
Published: December 2023

Abstract
Knowledge about health-related quality of life (HRQoL) over time in Fontan patients is sparse. We aimed to describe HRQoL over a ten-year period in a population-based Fontan cohort. Further, we compared HRQoL in Fontan patients with the general population. In 2011, Danish Fontan patients were invited to participate in a nationwide study assessing HRQoL. Depending on age, 152 participants filled out either the Pediatric Quality of Life Inventory or the 36-Item Short Form Health Survey. After a decade, patients from the initial study were invited to participate in a follow-up study. All were given the same questionnaire as in the first study, plus the 12-Item Short Form Health Survey (SF-12) as part of the Danish National Health Survey. HRQoL over time was described, and SF-12 scores were compared with the general population. A total of 109 Fontan patients completed the questionnaires in both studies. The mean patient age was 14.9 ± 6.6 years and 25.6 ± 6.5 years respectively. Despite an increase in complications, HRQoL did not decrease during the study period. Physical HRQoL scores were lower than mental HRQoL scores at both time points. The SF-12 physical component score was significantly lower in Fontan patients than in the general population (median score 52 vs. 56, p < 0.001), while the SF-12 mental component score was comparable (median score 51 vs. 50, p = 0.019). HRQoL remained stable over a ten-year period in a contemporary Danish Fontan cohort. Still, the physical HRQoL remained significantly lower than that of the general population.
Analysis of non-ventriculoperitoneal shunts at Red Cross War Memorial Children’s Hospital
Authors: De John B. G. , Figaji A. A. , Enslin J. M. N. 
Published: December 2023

Abstract
Background
At Red Cross War Memorial Children’s Hospital (RCCH), it is the preferred practice to use non-ventriculoperitoneal (non-VP) shunts when the peritoneum is ineffective or contraindicated for cerebrospinal fluid (CSF) diversion and when endoscopy is not an option. The objective of this study is to evaluate the clinical course of patients having undergone these procedures.

Method
A single-centre retrospective review at RCCH wherein 43 children with a total of 59 episodes of non-VP shunt placement over a 12-year period were identified for inclusion.

Results
Twenty-five ventriculoatrial (VA) and 32 ventriculopleural (VPL) shunts were analysed with a median age at insertion of 2.9 (0.3–14.9) and 5.3 years (0.5–13.4), respectively. The median number of previous shunt procedures prior to VA or VPL shunt insertion was 6.0 (2–28) versus 4.5 (2–17), respectively. Three VA (12.0%) and three VPL (9.4%) shunt patients were lost to follow-up. Of those remaining, 10 VA shunts (45.5%) compared to 19 (65,5%) VPL shunts required revision. One ventriculovesical shunt and one ventriculocholecystic shunt were placed in the same patient after 21 and 25 shunt-related procedures, respectively, and both were revised within 3 weeks of insertion. Median shunt survival was 8 months longer for the VA compared to the VPL shunts, being 13.5 (0–67) and 5 months (0–118), respectively. Complications for VA shunts were low, with the overall shunt sepsis rate in the VA group at 4% (n = 1) compared to 15.6% (n = 5) in the VPL group.

Conclusion
Our findings support that VA and VPL shunts are acceptable second-line options in an already compromised group of patients where safe treatment options are limited, provided attention is paid to the technical details specific to their placement.
Impact of dairy fat manipulation on endothelial function and lipid regulation in human aortic endothelial cells exposed to human plasma samples: an in vitro investigation from the RESET study
Authors: Markey Oonagh , Garcimartín Alba , Vasilopoulou Dafni , Kliem Kirsty E. , Fagan Colette C. , Humphries David J. , Todd Susan , Givens David I. , Lovegrove Julie A. , Jackson Kim G. 
Published: December 2023

Abstract
Purpose
Longer-term intake of fatty acid (FA)-modified dairy products (SFA-reduced, MUFA-enriched) was reported to attenuate postprandial endothelial function in humans, relative to conventional (control) dairy. Thus, we performed an in vitro study in human aortic endothelial cells (HAEC) to investigate mechanisms underlying the effects observed in vivo.

Methods
This sub-study was conducted within the framework of the RESET study, a 12-week randomised controlled crossover trial with FA-modified and control dairy diets. HAEC were incubated for 24 h with post-intervention plasma samples from eleven adults (age: 57.5 ± 6.0 years; BMI: 25.7 ± 2.7 kg/m2) at moderate cardiovascular disease risk following representative sequential mixed meals. Markers of endothelial function and lipid regulation were assessed.

Results
Relative to control, HAEC incubation with plasma following the FA-modified treatment increased postprandial NOx production (P-interaction = 0.019), yet up-regulated relative E-selectin mRNA gene expression (P-interaction = 0.011). There was no impact on other genes measured.

Conclusion
Incubation of HAEC with human plasma collected after longer-term dairy fat manipulation had a beneficial impact on postprandial NOx production. Further ex vivo research is needed to understand the impact of partial replacement of SFA with unsaturated fatty acids in dairy foods on pathways involved in endothelial function.
Hoffa fractures are associated with concomitant soft tissue injures and a high postoperative complication rate
Authors: Neumann-Langen M. V. , Eggeling L. , Glaab R. , von Rehlingen-Prinz F. , Kösters C. , Herbst E. 
Published: December 2023

Abstract
Introduction
Hoffa fractures are a rare and often overlooked entity. The main goal of surgical treatment is to restore the articular surface and maintain knee function. However, current clinical data indicate heterogeneous outcomes. The aim of this multicenter study was to obtain a representative data set of patients with isolated Hoffa fractures with special emphasis on concomitant soft tissue injuries, diagnostic algorithms, treatment strategies and functional outcomes.

Materials and methods
Participating Level I trauma centres were asked to review their internal database for isolated Hoffa fractures treated surgically between 2010 and 2020. Demographics, mechanism of injury, diagnostic and therapeutic algorithm, Letenneur classification, concomitant soft tissue injuries, and postoperative knee function and complications were analysed.

Results
A total of 56 patients from six participating trauma centres were included. The median age at injury was 45 years (15–94) with a median follow-up of 19 months (2–108). The most common mechanism of injury was high-energy trauma, with unicondylar lateral Letenneur type I and II fractures being the most common. Surgical treatment was independent of the type of fracture and included isolated screw fixation, combined plate and screw fixation and isolated plate osteosynthesis. Isolated screw fixation resulted in significantly better range of motion (ROM) values (p = 0.032), but the highest number of postoperative complications (n = 14/20, n.s.) compared to the other fixation techniques. The highest number of fixation failures requiring revision was observed in the plate and screw fixation group (n = 3/8, p = 0.008). Osteochondral flake fractures (n = 12/43, 27%) and lateral meniscus injuries (n = 5/49, 10%) were commonly seen in Hoffa fractures.

Conclusions
Treatment of Hoffa fractures with screw fixation resulted in significantly better functional outcomes, probably due to less comminuted fractures. Concomitant cartilage, meniscal and ligamentous injuries are common and warrant preoperative recognition and management.