bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between lower limb muscle strength and kinesiophobia with functional stability and knee function in anterior cruciate ligament reconstruction patients: a literature review
Authors: Gede Wahyu Pratama Wijaya  , I Putu Gde Surya Adhitya  , Anak Agung Gede Angga Puspa Negara  
Published: December 2023

Background: One of the most prevalent knee injuries among athletes is a torn anterior cruciate ligament (ACL). ACL injuries may lead to various unpleasant symptoms, including joint instability, muscular atrophy, and soreness. ACL reconstruction is usually recommended to restore peace and function to the knee joint. After ACL reconstruction, knee muscle strength can remain compromised, leading to deficits in stability and functional limitations. ACL reconstruction also has psychological consequences, such as fear of moving due to injury or kinesiophobia.
Purpose: To determine the relationship between lower leg muscle strength and kinesiophobia with functional stability and knee function in patients with ACL reconstruction.
Method: The research method used is a literature review using data from scientific articles in scientific journal databases related to muscle strength, kinesiophobia, functional stability, and knee function after ACL reconstruction. The literature search used the keywords "ACL," "Strength," "Function," and "Kinesiophobia" by combining the Boolean Operators" OR "and "AND."
Results: Based on the results of the journal review, it was found that after ACL reconstruction, muscle strength and kinesiophobia will affect the functional stability and function of the knee. Decreased muscle strength will lead to lower knee stability and function. Kinesiophobia level is associated with poorer clinical outcomes after ACL reconstruction.
Conclusion: Based on the review results, it can be concluded that there may be problems arising from ACL reconstruction. Decreased muscle strength and psychological consequences such as fear of moving due to injury or kinesiophobia can affect the knee's functional stability and function.
The relationship between knee function and psychology on sports readiness, overuse conditions, and physical activity post anterior aruciate ligament reconstructions: a literature review
Authors: Bondeng Vinzenza , Adhitya I Putu Gde Surya , Thanaya Sayu Aryantari Putri 
Published: December 2023

Background : Anterior cruciate ligament (ACL) injuries are injuries that result from a tear in the ligament that connects the femur and tibia. This injury can be treated with anterior cruciate ligament reconstruction (ACLR), which is an operation in the form of replacing the ACL ligament with other tissue grafts. ACLR can affect knee function so that it has an impact on readiness to return to sports, physical activity levels and the emergence of overuse conditions.
Objective : To determine the relationship between knee function and psychology on readiness to return to sports, overuse conditions, and physical activity after Anterior Cruciate Ligament Reconstructions.
Method : The method used is a literature review study using secondary data from published literature. The literature search was conducted online through PubMed, Pedro, Garuda and Google Scholar, using the “key words” Anterior cruciate ligament reconstructions (ACLR), ACL injury, psychological factors, physical activity of ACL athletes, and overuse injuries and selected based on inclusion and exclusion criteria.
Results : From the literature used, it is stated that poor knee function can cause severe pain and fear of re-injury so that it has an impact on readiness to return to sports and decreased levels of physical activity after ACLR. Poor knee function due to surgical factors such as the ipsilateral ACL autograft surgical technique can result in an overuse condition characterized by the emergence of patellofemoral pain syndrome.
Conclusion : There is a relationship between knee function on psychological readiness to return to sports, level of physical activity and overuse conditions in athletes after ACL reconstruction.
Keywords : ACL Reconstruction, Psychological Readiness and Physical Activity of ACLR Athletes.
Penerapan Pendidikan Agama Islam Melalui Budaya Religius (Application of Islamic Relegios Education Through Religios Cultural)
Authors: Siregar Ririn Suriani 
Published: December 2023

The education system of Islamic Religion in is a form of elaboration of the mandate of Act No. 20 of 2003 on National Education System, in order to prepare students to be a man of faith and piety and morality, but in practice they have drawn criticism from the public that PAI in school during is rated only equip learners only religious knowledge (cognitive) less emphasis on the aspect of practice (affective andpsychomotor).Where necessary the development of PAI itself, so that PAI is not only limited knowledge but also can be practiced in everyday life either at school or in everyday environments. Either by teachers, and students. Therefore, it is necessary to build a culture of religious (religious culture) in religious activities in schools to improve the practice of affective so in tune with our educational goals.The quality of education will be achieved, if it is supported by all who are organized education component with all considerations. Some of those components are inputs, processes, and outputs, and need full support from those who have an important role in educational institutions. But one thing that is the focus here is that it is very important for education to implement religious values into independent education by using religious culture in its daily application so that students or society remain morally Islamic every day and to always remember Allah swt. Kata kunci: Pendidikan; Religi ,dan Islam Budaya Keagamaan (Budaya keagamaan)
Peranan Pembelajaran Kitab Ta’lim Muta’allim Thariqatta’allum Karangan Syaikh az-Zarnuji Terhadap Akhlak Siswa Di MA Swasta Dar Al-Ma’arif Basilam Baru
Authors: Harahap Barani , Hasibuan Zainal Efendi 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui (1) Proses Pembelajaran Kitab Ta’lim Muta’allim Thariqatta’allum di MA Swasta Dar Al-Ma’arif Basilam Baru (2) Keadaan Akhlak Siswa di MA Swasta Dar Al-Ma’arif Basilam Baru (3) Peranan Pembelajaran Kitab Ta’lim Muta’allim Thariqatta’allum terhadap akhlak siswa di MA Swasta Dar Al-Ma’arif Basilam Baru. Penelitian ini dilakukan di MA Swasta Dar Al-Ma’arif Basilam Baru. Penelitian ini menggunakan metode kualitatif yaitu meneliti pelaksanaan pembelajaran kitab Ta’lim Muta’allim Thariqatta’allum karangan syaikh az-Zarnuji di MA Swasta Dar al-Ma’arif Basilam Baru dan pengaruhnya terhadap akhlak siswa di MA Swasta Dar Al-Ma’arif Basilam Baru. Teknik analisis data dilakukan dengan 1. reduksi data, 2. penyajian data dan 3. penarikan kesimpulan. Selanjutnya informan dalam penelitian ini adalah guru kitab Ta’lim Muta’allim Thariqatta’allum, siswa dan kepala madrasah MA Swasta Dar Al-ma’arif Basilam Baru. Hasil menunjukkan bahwa pembelajaran kitab Ta’lim Muta’allim Thariqatta’allum tergolong baik ditinjau dari tujuan, metode, media dan evaluasi pembelajaran. Akhlak siswa di sekolah ini secara umum adalah baik. Peranan pembelajaran kitab Ta’lim Muta’allim Thariqatta’allum terhadap akhlak siswa terbagi kepada tiga macam yakni pertama akhlak kepada guru, orang tua dan teman, kedua menghindarkan siswa dari kenakalan remaja dan ketiga akhlak (adab) kepada kitab.
Los comerciantes extranjeros en el Callao y sus conexiones con los puertos del Pacífico norte 1819-1829
Authors: Mazzeo Cristina 
Published: December 2023

A partir de la coyuntura del comercio neutral el intercambio entre España y América se vio entorpecido. La situación se precipitó a partir de 1814 hasta 1821, especialmente en el Pacífico Sur, debido a los acontecimientos bélicos. Fue a partir de 1818 con la Independencia de Chile que muchos comerciantes extranjeros aprovecharon para ingresar al circuito del comercio español americano instalándose principalmente en el puerto del Callao. Analizaremos los circuitos mercantiles en el área del Pacífico norte a partir del puerto del Callao hacia California, pasando por puertos centroamericanos (Sonsonate, Realejo), San Blas en México en el período de transición entre el imperio y los nuevos estados (1819-1829), para comparar lo ya investigado para el área sur (Callao- Valparaíso- Buenos Aires) durante el mismo tiempo.
Partimos de datos referentes a embarcaciones, hombres y mercancías que se desplazaron por el Pacífico. ¿Cómo impactaron las coyunturas bélicas en el Pacífico norte? ¿Fueron los mismos comerciantes extranjeros y norteamericanos los que participaron en los circuitos norte al igual que en los del sur? ¿Cuáles fueron los productos de intercambio? Esta investigación nos permitiría visualizar los intercambios mercantiles a partir del puerto del Callao en el período de transición entre la etapa virreinal y republicana.
Road traffic injuries and alcohol use in the emergency department in Tanzania: a case-crossover study
Authors: Staton Catherine 
Published: December 2023

Abstract
Introduction: Alcohol is the leading risk factor for road traffic injury (RTI). Africa has the second-highest rate of alcohol dependence and the highest road traffic fatality rate. We describe the proportion of Tanzanian emergency department (ED) patients presenting with RTIs who are blood alcohol content (BAC) positive and determine the dose-response relationship between drinking and injury risk.Methods: Analysis of data from EDs in Tanzania from 2013 to 2014 was performed. Adults presenting to an ED within 6 hours of injury had BAC testing and were asked whether and how much alcohol was consumed prior to the injury. Data also included self-reported alcohol use during control periods 1 day and 1 week prior to the injury. Case-crossover analysis of injury risk used logistic regression to determine matched-pair odds ratios (ORs) and 95% confidence intervals (CIs).Results: Of 513 injury patients, 375 (73%) suffered RTIs. Overall, 29% of RTI patients were BAC-positive. Approximately 40% of those who reported using alcohol prior to RTI reported drinking more than 5 standard drinks. With any alcohol, drivers of both motorcycles and cars/trucks had increased odds of RTI (4.90 OR (CI 2.5-9.5) and 5.70 OR (CI 2.8-11.6) respectively). While the odds of RTI in car/truck drivers demonstrated a dose-dependent response, that in motorcyclists was highest after 3-4 drinks (5.60 OR, CI 2.22-14.10).Discussion: The RTI burden in Tanzania is high. Any alcohol can increase RTI risk. These findings should guide drunk-driving legislation.
Titanium Multi‐Topology Metamaterials with Exceptional Strength
Authors: Noronha Jordan , Dash Jason , Rogers Jason , Leary Martin , Brandt Milan , Qian Ma 
Published: December 2023

AbstractAdditively manufactured metamaterials are architectured cellular materials that can be engineered through structural innovations to achieve unusual mechanical and multifunctional properties. Among these, hollow‐strut lattice (HSL) metamaterials have proven to allow outstanding structural efficiency, with a multifunctional architecture ideal for lightweight, biomedical, microfluidic, and thermal engineering. To capitalize on their structural efficiency and significantly extend their mechanical envelope, a thin‐plate lattice topology is seamlessly integrated into the inner hollow space of an HSL topology. This integration serves a dual purpose: to radically enhance the resistance of the irregular HSL nodes to deformation and to uniformly distribute the applied stresses in the new topology for unparalleled strength. Fabricated in titanium alloy Ti‐6Al‐4V with densities of 1.0–1.8 g cm−3 , this thin‐plate integrated hollow‐strut lattice (TP‐HSL) metamaterials achieve relative yield strength that well surpasses the empirical upper limit of all cellular metals, including HSL and solid‐strut lattice (SSL) metamaterials made from various metallic alloys. Furthermore, their absolute yield strength drastically exceeds that of magnesium alloys with comparable densities while inheriting the high corrosion resistance, biocompatibility, heat resistance, and other unique attributes of Ti‐6Al‐4V. Titanium multi‐topology metamaterials expand the boundaries of lightweight multifunctional metallic materials.
Regioselective Reductive Elimination from Bismuth(V) Compounds for Aryl Transfer to Nucleophiles
Authors: Debnath Shuvra , DiMagno Stephen G. , Wink Donald J. , Lemley Audra G. , Kelly James M. 
Published: December 2023

AbstractWe demonstrate that regioselective aryl transfer to the nucleophile occurs rapidly under mild conditions via reductive elimination and show that regioselectivity is primarily governed by steric factors imparted by ortho substituents on the recipient ring. Computational modeling and x‐ray crystallography confirm that the recipient aryl ring is positioned in the equatorial coordination site and oriented orthogonally to the axial X−Bi−Ph bond (X=nucleophile) in a trigonal bipyramidal structure. The orientation of the ortho‐substituted aryl ring allows the appropriate orbital to overlap between its ipso carbon and nucleophile, which enhances the rate of aryl transfer to the nucleophile and dictates the regioselective reductive elimination from Bi(V) compounds. This level of stereoelectronic control results in significantly enhanced reaction rate and selectivity and creates an opportunity to rationally design ligand systems for selective aryl transfer reactions.
Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL‐INCA
Authors: Stickel Ariana M. , Tarraf Wassim , Kuwayama Sayaka , Wu Benson , Sundermann Erin E. , Gallo Linda C. , Lamar Melissa , Daviglus Martha , Zeng Donglin , Thyagarajan Bharat , Isasi Carmen R. , Lipton Richard B. , Cordero Christina , Perreira Krista M. , Gonzalez Hector M. , Banks Sarah J. 
Published: December 2023

AbstractINTRODUCTIONReproductive health history may contribute to cognitive aging and risk for Alzheimer's disease, but this is understudied among Hispanic/Latina women.METHODSParticipants included 2126 Hispanic/Latina postmenopausal women (44 to 75 years) from the Study of Latinos‐Investigation of Neurocognitive Aging. Survey linear regressions separately modeled the associations between reproductive health measures (age at menarche, history of oral contraceptive use, number of pregnancies, number of live births, age at menopause, female hormone use at Visit 1, and reproductive span) with cognitive outcomes at Visit 2 (performance, 7‐year change, and mild cognitive impairment [MCI] prevalence).RESULTSYounger age at menarche, oral contraceptive use, lower pregnancies, lower live births, and older age at menopause were associated with better cognitive performance. Older age at menarche was protective against cognitive change. Hormone use was linked to lower MCI prevalence.DISCUSSIONSeveral aspects of reproductive health appear to impact cognitive aging among Hispanic/Latina women.
Obstructive azoospermia caused by epididymis injury with testicle rupture on the other side
Authors: Ueda Takayuki , Yanagi Masato , Katsu Akifumi , Kono Hiroyoshi , Kimata Ryoji , Hamasaki Tsutomu , Kondo Yukihiro 
Published: December 2023

AbstractBackgroundEpididymal injuries without ipsilateral injuries of the testicles are rare. We report a case of a solitary right epididymal injury complicated by left testicular rupture.Case PresentationA 21‐year‐old man experienced scrotal trauma caused by a motorcycle accident. Bilateral swelling and tenderness of the scrotum were observed. Ultrasonography and computed tomography revealed a ruptured left testicle; therefore, surgery was performed. During surgery, the left testicle was excised because it was completely ruptured, and the right testicle and epididymis were evaluated to identify the cause of swelling of the right scrotum. The right testis was not injured; however, the right epididymis was lacerated. Subsequently, the lacerated right epididymis was repaired using sutures. A semen analysis performed at 1, 4, and 7 months after surgery revealed the absence of sperm in the semen.ConclusionEpididymal injuries should be considered as differential diagnoses for scrotal trauma.
Deciphering the genetic architecture of anther culturability in rice using segregation distortion approach
Authors: Dai Yuting , Hu Qiyan , Ye Junhua , Tu Rongjian , Xie Kaizhen , Qiu Yue , Cheng Can , Zhou Jihua , Niu Fuan , Sun Bin , Zhang Anpeng , Zeng Yanhua , Cao Liming , Chu Huangwei 
Published: December 2023

AbstractAnther culture is a promising technique used in rice (Oryza sativa L.) breeding, although the genetic mechanisms associated with anther culturability remain elusive. In the process of in vitro anther culture, favorable alleles for anther culture are preferentially transmitted to doubled haploid (DH) populations, resulting in biased segregation of DH populations. Therefore, the segregation distortion (SD) method is an ideal approach for mapping the genetic loci controlling anther culturability. Performing a SD analysis using a genetic map consisting of 666 single nucleotide polymorphism markers, we identified five potential loci (logarithm of odds [LOD] > 3.5) that may be associated with anther culturability, including SDL2 and SDL3, which are overrepresented in japonica alleles, and SDL7, SDL9, and SDL11, which are overrepresented in indica alleles. In addition, nine pairs of epistatic interactions (EPIs) that contribute significantly (p < 0.05) to SD in the DH population were identified. Among them, the interaction between SDL2 and SDL3 is particularly noteworthy. These findings suggest that anther culturability in rice is governed by complex genetic mechanisms involving multiple nuclear genes and EPIs. This study provides insights into the genetic control underlying anther culturability in rice and lays the foundation for future research aimed at identifying causal genes associated with anther culturability.
PF465 UPREGULATION OF CD276 IN ENDOTHELIAL CELLS OF MURINE AND PDX ACUTE MYELOID LEUKAEMIA MODELS
Authors: Batsivari A. , Passaro D. , Chakravarty P. , Albornoz M.G. , Diana G. , Ariza McNaughton L. , Abarrategi A. , Bonnet D. 
Published: December 2023

Background:Haematopoietic stem cells (HSCs) reside atop of the blood hierarchy and localise in the bone marrow (BM). Acute myeloid leukaemia (AML) is caused by accumulation of mutations in the stem cell compartment, which blocks the differentiation of the myeloid lineage. AML also modulates the BM microenvironment but the mechanisms of action are largely unknown. We and others, demonstrated recently that BM marrow vasculature is damaged in AML engrafted mice (Passaro et al. 2017; Duarte et al. 2018). The arterioles are increased, while the sinusoidal endothelial cells are vastly decreased. In order to understand the mechanism underlining this change, we previously performed RNA‐sequencing of CD31+ endothelial cells (ECs) extracted from healthy and leukemic mice.Aims:This project aims to identify key processes that play a role in the crosstalk between AML cells and BM microenvironment and test whether modulating these niche factors can improve the current therapeutic regimen. Thus, herein we focused on the potential role of CD276 on ECs of AML engrafted mice.Methods:RNAseq of BM ECs from non‐transplanted or AML Patients’ Derived Xenograft (PDX) mice was performed. Flow cytometry and immunostaining of BM ECs were performed. ShRNA against CD276 is being used to define the effect of its knockdown in ECs on leukaemia engraftment in our 3D humanised scaffold model. Blocking antibodies against CD276 will also be tested in vivo.Results:Analysis of the RNAseq data showed that CD276 (B7‐H3) gene is among the top 100 differentially expressed genes and is particularly upregulated in ECs of AML engrafted mice. It has been demonstrated that CD276 is overexpressed specifically in ECs of solid tumours and its blockade leads to tumour shrinkage (Seaman et al. 2017). The protein network map of CD276 indicated that it can participate in immune responses as well as adhesion signalling pathways. Indeed, there are several such genes deregulated in the leukemic ECs suggesting that CD276 might have a functional role in transforming the BM niche. CD276 overexpression was validated in ECs PDX and murine AML models. Moreover, we also observed this upregulation in human ECs by using our humanised scaffolds seeded with AML cell lines.Summary/Conclusion:So far, our RNAseq analysis of healthy and leukemic PDX mice shows that CD276 is being upregulated in ECs. We confirmed this upregulation at the protein level both using mouse and human ECs. Our next step is to determine the consequence of CD276 downregulation on leukaemia engraftment.
PF473 PEDIATRIC HODGKIN LYMPHOMA: DISPARITIES IN SURVIVAL BY RACE
Authors: Khullar K. , Rivera‐Núñez Z. , Jhawar S. , Drachtman R. , Cole P. , Hoppe B. , Parikh R. 
Published: December 2023

Background:The association between race and survival has not been well established for patients with pediatric Hodgkin Lymphoma (HL).Aims:The purpose of this study was to examine the disparities in overall survival (OS) by race in a large cohort of patients with pediatric HL.Methods:We evaluated clinical features and survival outcomes among patients ≤21 years of age diagnosed with stage I‐IV HL from 2004 to 2015 from the prospectively collected National Cancer DataBase (NCDB). The association between patient‐reported race and OS was assessed in a multivariable Cox proportional hazards model.Results:Among 11,546 patients with pediatric HL ≤21 years of age within the NCDB, a total of 9,285 patients with stage I‐IV disease were eligible for this study, with a median follow‐up of 5 years. The race status was as follows: 7,722 (83%) White; 1,136 (12%) Black, and 427 (5%) other. Black patients were found to be younger (<15), lower stage at diagnosis, more commonly with “B” symptoms, less likely to have nodular‐sclerosis histology, more likely to be lower income and education quartiles, and under/uninsured (all p < 0.01). Treatment interventions among races was similar (use of chemotherapy, radiation therapy, or combined modality therapy). Patients of Black race experienced a 5‐year OS of 91.5% vs. 95.9% compared to their White counterparts (p < 0.01). This difference in OS persisted across all stratified stages (I‐IV). When adjusting for all co‐variates, Black race was associated with significantly decreased OS (HR = 1.50; 95% CI, 1.12–1.99, p < 0.01). In risk factor stratification by race,age <15, stage IV disease, presence of B symptoms, use of radiation, and income were prognostic factors for OS in White patients, but not for Black patients. Effect measure modification was also utilized to assess the interaction between socioeconomic parameters (education/income/insurance status) and race and no significant interaction was found. In sensitivity analysis including age groups of ≤15 years, 16–18 years, and >18 years of age, Black race was associated with poorer OS among all age groups compared to Whites with rates of 95.4% vs 97.7%, 87.1% vs 96.1%, and 91.6% vs 94.6% respectively.Summary/Conclusion:Our study reveals that among pediatric patients with HL, Black race was associated with lower overall survival, across all disease stages and pediatric age groups. To our knowledge, this study represents the largest dataset examining the role of race on survival for pediatric patients with HL. Further studies are necessary to elucidate the causes of these differences in order to facilitate optimal treatment of pediatric HL patients in the era of risk‐stratified, response‐based treatment.image