bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of sensitivity of acoustic reflex decay test in diagnosis of patulous eustachian tube
Authors: Attia Alia Ali Ahmed , Abou-Setta Alaa Eldin Ahmed , Ashary Yehia Mohammed 
Published: February 2024

Abstract
Background
It has long been believed that the patulous eustachian tube is a unique but uncommon condition, with an estimated incidence ranging from 0.3 to 6.6% in the general population. Hearing one’s own voice and breathing, or autophony and aerophony, are the most common symptoms of PET, along with frequent auditory fullness.

Aim
This study is to establish a standardized protocol for the audiological evaluation of patulous Eustachian tube using acoustic reflex decay test during different breathing tasks.

Methods
Between January 2022 and December 2022, the ENT department at Suez Canal University Hospitals undertook an observational case-control study. Fifty-two adult patients who present to the Suez Canal University ENT department with complaints of autophony, auditory fullness, or aerophony are diagnosed with patulous eustachian tube dysfunction through endoscopic examination of the tympanic membrane’s synchronized movement with respiration.

Results
The incidence rate of PET among adults was approximately 3 patients/1000 patients/year. The age of the whole studied group ranged from 20 to 60 years with mean ± SD of 37.4 ± 12.6 years. They included 23 males (44.2%) and 29 females (55.8%). The most common symptom among the studied group was aural fullness (46%), while the least common symptom was aerophony (12%); the most common risk factor among the studied patients was allergy (46.2%), while the least common was radiotherapy (3.9%); 66.7% of the patients with GERD were males, while 66.7% of the patients who lost weight were females; 58.3% of the patients with allergies were females, and also 60% of the patients with thin built were females. In the case group, there is a significant higher change of middle ear compliance in ipsilateral nostril breathing than the mouth breathing and nasal breathing. The sensitivity of the acoustic reflex decay test to diagnose PET with reference to the gold standard test is 88.5% (23/26*100), the specificity is 100% (26/26*100), and the positive predictive value is 100% (23/23*100).

Conclusion
The sensitivity of the acoustic reflex decay test to diagnose PET with reference to the gold standard test is high, and the specificity is very high with very good diagnostic accuracy.
Dissection of mRNA ac4C acetylation modifications in AC and Nr fruits: insights into the regulation of fruit ripening by ethylene
Authors: Ma Lili , Zheng Yanyan , Zhou Zhongjing , Deng Zhiping , Tan Jinjuan , Bai Chunmei , Fu Anzhen , Wang Qing , Zuo Jinhua 
Published: February 2024

AbstractN4-acetylcytidine (ac4C) modification of mRNA has been shown to be present in plant RNAs, but its regulatory function in plant remains largely unexplored. In this study, we investigated the differentially expressed mRNAs, lncRNAs and acetylation modifications of mRNAs in tomato fruits from both genotypes. By comparing wild-type (AC) tomato and the ethylene receptor-mutant (Nr) tomato from mature green (MG) to six days after the breaker (Br6) stage, we identified differences in numerous key genes related to fruit ripening and observed the corresponding lncRNAs positively regulated the target genes expression. At the post-transcriptional level, the acetylation level decreased and increased in AC and Nr tomatoes from MG to Br6 stage, respectively. The integrated analysis of RNA-seq and ac4C-seq data revealed the potential positive role of acetylation modification in regulating gene expression. Furthermore, we found differential acetylation modifications of certain transcripts (ACO, ETR, ERF, PG, CesA, β-Gal, GAD, AMY, and SUS) in AC and Nr fruits which may explain the differences in ethylene production, fruit texture, and flavor during their ripening processes. The present study provides new insights into the molecular mechanisms by which acetylation modification differentially regulates the ripening process of wild-type and mutant tomato fruits deficient in ethylene signaling.
Graphical Abstract
The effectiveness of geothermal systems in cooling residential buildings: a case study of a residential building in Alexandria, Egypt
Authors: Fouad Heba , Mahmoud Ayman H. , Moussa Rania Rushdy 
Published: February 2024

AbstractThe urbanization of cities, the corroding of green areas, and the increasing demand for electric energy lead to the formation of heat islands in cities and the appearance of the global climate change phenomenon.Therefore, it was necessary to resort to the use of renewable energy sources, such as geothermal energy, to be used in different applications, as it can be used to cool buildings in cities during the summer.This research deals with the benefits of using geothermal energy systems, their different types, and the possibility of their application in Egypt. Also discussing the effectiveness of the vertical closed geothermal system in residential buildings in Alexandria Governorate in Egypt to reach an answer to a question.The effectiveness of the geothermal energy system in residential buildings is to reduce the problem of rising temperatures, energy consumption for cooling, and carbon emissions and thus reduce the problem of the formation of heat islands in cities and the appearance of the global climate change phenomenon and reaching a sustainable, environmentally friendly building that achieves thermal comfort for humans through the use of a simulation program called TRNSYS-17, through which the current situation of the building was compared and the addition of a vertical closed geothermal system was assumed, the extent of its effectiveness was compared in the whole building, and the cost of a vertical closed geothermal system and a traditional air conditioning system (HVAC) in a building was compared (case study).Hence, the efficiency of the vertical closed geothermal system appeared to reduce electric energy consumption and carbon emissions in the whole building at Alexandria in Egypt, especially the ground floor, which reached thermal comfort for humans and worked to reduce electricity consumption and carbon emissions by up to 22.93% in the building as a whole.
Inversion of fracture weakness parameters based on 3C vertical seismic profile data — Part I: Horizontal transversely isotropic media composed of a single fracture set in the isotropic background media
Authors: Yang Yuyong , Stovas Alexey , Qi Qiaomu , Zhou Huailai 
Published: February 2024

Natural fractures in oil and gas reservoirs are a crucial factor that cannot be ignored because they significantly influence the reservoir’s petrophysical properties and hydrocarbon development. A horizontal transversely isotropic (HTI) medium composed of a single fracture set in an isotropic background is a typical anisotropic medium. Meanwhile, the S-wave splitting is a sensitive response of such anisotropic media, resulting in the generation of fast and slow S waves. The normal and tangential fracture weaknesses are crucial parameters that characterize the anisotropy of fractured media. We develop an inversion method for fracture weakness based on 3C vertical seismic profiling (3CVSP) data. First, assuming weak anisotropy and an HTI medium containing a single fracture set, we derive a first-order linear approximation of the traveltimes of the converted fast and slow S waves (PS1 and PS2 waves) with respect to fracture weakness parameters in the phase velocity domain. By solving for the horizontal projection of the slowness vector, approximate equations of the traveltimes of the PS1 and PS2 waves are converted from the phase velocity domain to the group velocity domain. Furthermore, we devise an inversion workflow consisting of three primary steps: (1) preprocessing the VSP data to derive the traveltimes and azimuth of the HTI medium, (2) constructing a forward model with undetermined fracture weakness parameters, and (3) following the establishment of the objective function, conducting the inversion for the fracture weakness parameters. We demonstrate the reliability of the method through numerical examples and synthetic 3CVSP data. The inversion errors are primarily influenced by the azimuth angle, with minimal influence from the receiver depth. Furthermore, a collective set of inverted results derived from all geophones is more stable and accurate than individual geophones. The application to actual 3CVSP data further confirms the effectiveness of our approach.
Medial surface plating of posterior column through the anterior intrapelvic approach in acetabulum fractures with involvement of both columns
Authors: Hazra Sunit , Saha Nabarun , Mallick Sunny K. , Saraf Amit , Kumar Sanjay , Ghosh Sandip , Chandra Mainak 
Published: February 2024

AimsPosterior column plating through the single anterior approach reduces the morbidity in acetabular fractures that require stabilization of both the columns. The aim of this study is to assess the effectiveness of posterior column plating through the anterior intrapelvic approach (AIP) in the management of acetabular fractures.MethodsWe retrospectively reviewed the data from R G Kar Medical College, Kolkata, India, from June 2018 to April 2023. Overall, there were 34 acetabulum fractures involving both columns managed by medial buttress plating of posterior column. The posterior column of the acetabular fracture was fixed through the AIP approach with buttress plate on medial surface of posterior column. Mean follow-up was 25 months (13 to 58). Accuracy of reduction and effectiveness of this technique were measured by assessing the Merle d’Aubigné score and Matta’s radiological grading at one year and at latest follow-up.ResultsImmediate postoperative radiological Matta’s reduction accuracy showed anatomical reduction (0 to 1 mm) in 23 cases (67.6%), satisfactory (2 to 3 mm) in nine (26.4%), and unsatisfactory (> 3 mm) in two (6%). Merle d’Aubigné score at the end of one year was calculated to be excellent in 18 cases (52.9%), good in 11 (32.3%), fair in three (8.8%), and poor in two (5.9%). Matta’s radiological grading at the end of one year was calculated to be excellent in 16 cases (47%), good in nine (26.4%), six in fair (17.6%), and three in poor (8.8%). Merle d’Aubigné score at latest follow-up deteriorated by one point in some cases, but the grading remained the same; Matta’s radiological grading at latest follow-up also remained unchanged.ConclusionStabilization of posterior column through AIP by medial surface plate along the sciatic notch gives good stability to posterior column, and at the same time can avoid morbidity of the additional lateral window.Cite this article: Bone Jt Open 2024;5(2):147–153.
Entertainment, Journalism, and Advocacy: Competing Motivations in the True Crime Podcast Ecosystem, Lindsey A. Sherrill (2023)
Authors: Graham Caroline 
Published: February 2024

Review of: Entertainment, Journalism, and Advocacy: Competing Motivations in the True Crime Podcast Ecosystem, Lindsey A. Sherrill (2023)
Blue Ridge Summit, PA: Lexington Books, 230 pp.,
ISBN 978-1-66690-601-1, h/bk, USD 100.00
ISBN 978-1-66690-602-8, e-book, USD 45.00
Investigation of crude methanolic extract from poison secreted by the Rhaebo gutattus on status redox antioxidant in mice
Authors: Pelissari Sheila Rodrigues do Nascimento , Sinhorin Valéria Dornelles Gindri , Rodrigues Domingos de Jesus , Shen Lee Yun , Castoldi Lindsey , Sinhorin Adilson Paulo 
Published: February 2024

The study evaluated the antioxidant properties of a crude methanolic extract (CME) from Rhaebo guttatus poison in mice over a period of 7 and 30 days. The mice were divided into groups and treated with different concentrations of the extract (0; 8 μg mL-1; 16 μg mL-1 and 32 μg mL-1 or vehicle; 100 μL/animal/day; via gavage). The liver samples were analyzed for status redox parameters as catalase (CAT), glutathione-S-transferase (GST), reduced glutathione (GSH) and thiobarbituric acid reactive substances (TBARS). The results showed that the CME caused changes in the levels of various antioxidants and oxidative stress markers. At 7 days, there was an increase in TBARS levels (8 μg mL-1 dose) and GST activity (16 μg mL-1 dose), and a reduction in GSH levels (32 μg mL-1 dose) compared to the control group. At 30 days, TBARS and GSH levels returned to control values in the same period, but GSH increased (32 μg mL-1 dose) compared at 7 days; GST activity remained high after 30 days for 32 μg mL-1 dose compared other groups and time of treatment (7 days). Overall, the study suggests that the extract modulates antioxidant properties per se that can affect various markers of status redox in the liver of mice, mainly 16 μg mL-1 dose demonstrated to act under antioxidant enzymes in different times (7 or 30 days).
Investigating translanguaging strategies and online self-presentation through internet slang on Douyin (Chinese TikTok)
Authors: Li Ziqi , Wang Li 
Published: February 2024

Abstract
This study explores the translanguaging strategies used in internet slang on Douyin, a popular social media platform in China. By analyzing 331 examples (encompassing 313 translanguaging strategies), we investigate how individuals utilize various translanguaging resources, including multimodal, multilingual, multisemiotic, and multisensory resources, to manage their online self-presentation. Our findings suggest that multilingual resources, such as new Chinglish, Pinyin initialism, and hybrid words (combining Chinese, English, and Arabic numerals), were the most frequently used strategies. Additionally, we found that multisensory resources, including homophonic puns and modal particles, were also commonly utilized. In contrast, multimodal resources, such as emojis, and multisemiotic resources, such as keyboard-generated emoticon, hashtag, and punctuation mark, were less frequently employed. These findings reveal that Chinese internet users display a high degree of creativity and adaptability in their online communication, drawing on a wide range of linguistic and semiotic resources to express their identities and project their desired image. Overall, this study highlights the importance of translanguaging in online communication and its role in shaping self-presentation in the digital age.
Association of prehospital lactate levels with base excess in various emergencies – a retrospective study
Authors: Eichinger Michael , Shah Karan , Palt Niklas , Eichlseder Michael , Pichler Alexander , Zoidl Philipp , Zajic Paul , Rief Martin 
Published: February 2024

Abstract

Objectives
Blood gas analysis, including parameters like lactate and base excess (BE), is crucial in emergency medicine but less commonly utilized prehospital. This study aims to elucidate the relationship between lactate and BE in various emergencies in a prehospital setting and their prognostic implications.

Methods
We conducted a retrospective analysis of prehospital emergency patients in Graz, Austria, from October 2015 to November 2020. Our primary aim was to assess the association between BE and lactate. This was assessed using Spearman’s rank correlation and fitting a multiple linear regression model with lactate as the outcome, BE as the primary covariate of interest and age, sex, and medical emergency type as confounders.

Results
In our analysis population (n=312), lactate and BE levels were inversely correlated (Spearman’s ρ, −0.75; p<0.001). From the adjusted multiple linear regression model (n=302), we estimated that a 1 mEq/L increase in BE levels was associated with an average change of −0.35 (95 % CI: −0.39, −0.30; p<0.001) mmol/L in lactate levels. Lactate levels were moderately useful for predicting mortality with notable variations across different emergency types.

Conclusions
Our study highlights a significant inverse association between lactate levels and BE in the prehospital setting, underscoring their importance in early assessment and prognosis in emergency care. Additionally, the findings from our secondary aims emphasize the value of lactate in diagnosing acid–base disorders and predicting patient outcomes. Recognizing the nuances in lactate physiology is essential for effective prehospital care in various emergency scenarios.
Efficacy of behavioral interventions to increase engagement in sexual health services among LatinX youth in the United States: A meta-analysis for post-pandemic implications
Authors: Rosen Aviana O. , Bergam Lauren , Holmes Ashley L. , Krebs Emma , Moreno Melanie , Muñiz Geycel S. , Huedo-Medina Tania B. 
Published: February 2024

Abstract

Introduction
LatinX youth in the U.S. are disproportionately affected by HIV and STIs, commonly attributed to a lack of diagnostic testing and regular physician consultations to address sexual health. These disparities have been exacerbated by the COVID-19 pandemic. This meta-analysis seeks to assess the efficacy of behavioral interventions among LatinX youth in the U.S. that aim to increase engagement in sexual health services (i.e., STI/HIV testing, physician consultations).

Content
Following PRISMA guidelines, seven electronic databases were searched. We systematically extracted data with a coding form, and effect sizes were obtained from each study on HIV/STI testing outcomes and physician consultation. Moderator analyses were run for demographic and intervention characteristics.

Summary and Outlook
Of nine included studies, the interventions created a small-to-moderate effect on increased engagement of sexual health services (d
+=0.204, 95 % CI=0.079, 0.329). Moderator analyses showed that interventions including the following characteristics were most efficacious at facilitating care services: community-based or online setting, access to diagnostic testing, social media/remote components, parental involvement, and longer session duration. This meta-analysis provides informative results regarding behavioral interventions that have proven efficacious in facilitating engagement in sexual health services among LatinX youth. Most prominently, interventions that are remote or through social media, community-based, and incorporated parents had large positive effects. These findings prove useful for the ongoing COVID-19 pandemic situation and provide guidance for targeting LatinX youth to engage them in sexual health services as primary and secondary STI and HIV prevention.
Salami slicing and other kinds of scientific misconduct: A faux pas for the author, a disaster for science
Authors: Köstenbach Tamara , Oransky Ivan 
Published: February 2024

Abstract
As part of the research project “Summa cum fraude – Wissenschaftliches Fehlverhalten und der Versuch einer Gegenoffensive” at Saarland University (funded by the Deutsche Forschungsgemeinschaft DFG) an interview with Ivan Oransky in October 2022 was conducted. He became well-known for co-founding the Retraction Watch Database and the Retraction Watch blog, which covers topics such as retracting published articles or exposing misconduct in science.
The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish
Authors: Yang Yuan , Yang Hao , Kiskin Fedir N. , Zhang Joe Z. 
Published: February 2024

Abstract
Cardiovascular research has heavily relied on studies using patient samples and animal models. However, patient studies often miss the data from the crucial early stage of cardiovascular diseases, as obtaining primary tissues at this stage is impracticable. Transgenic animal models can offer some insights into disease mechanisms, although they usually do not fully recapitulate the phenotype of cardiovascular diseases and their progression. In recent years, a promising breakthrough has emerged in the form of in vitro three-dimensional (3D) cardiovascular models utilizing human pluripotent stem cells. These innovative models recreate the intricate 3D structure of the human heart and vessels within a controlled environment. This advancement is pivotal as it addresses the existing gaps in cardiovascular research, allowing scientists to study different stages of cardiovascular diseases and specific drug responses using human-origin models. In this review, we first outline various approaches employed to generate these models. We then comprehensively discuss their applications in studying cardiovascular diseases by providing insights into molecular and cellular changes associated with cardiovascular conditions. Moreover, we highlight the potential of these 3D models serving as a platform for drug testing to assess drug efficacy and safety. Despite their immense potential, challenges persist, particularly in maintaining the complex structure of 3D heart and vessel models and ensuring their function is comparable to real organs. However, overcoming these challenges could revolutionize cardiovascular research. It has the potential to offer comprehensive mechanistic insights into human-specific disease processes, ultimately expediting the development of personalized therapies.
Crystal structure of hexaaquazinc(II) catena-poly[bis(1-(3-carboxyphenyl)-5-methyl-4-oxo-1,4-dihydropyridazine-3-carboxylato-κ2O,O′)-bis(μ2-1-(3-carboxyphenyl)-5-methyl-4-oxo-1,4-dihydropyridazine-3-carboxylato-κ2O:O′)trizinc(II)] hexahydrate C26H36N4O20Zn2
Authors: Pan Hui-Bin , Gao Jia-Hao , Huang Pei-Pei , Wang Jia-Xin , Wu Ting-Ting , Lu Jiu-Fu 
Published: February 2024

Abstract
C26H36N4O20Zn2, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 6.9872(4) Å, b = 8.9052(5) Å, c = 8.9052(5) Å, α = 94.441(4)°, β =

93.552

(
4
)

°

$93.552(4){}^{\circ}$

, γ =

90.045

(
5
)

°

$90.045(5){}^{\circ}$

, V = 1651.61(16) Å3, Z = 2,

R

g
t

${R}_{gt}$

(F) = 0.0748,

w

R

r
e
f

$w{R}_{ref}$

(F
2) = 0.2021, T = 293 K.
Crystal structure of catena-poly[triaqua-(μ2 -1-(4-carboxylatophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylato-κ3
O,O′:O′′)manganese(II)], C12H12N2O8Mn
Authors: Yan Zhang , Jing Ge , Peng Zhou 
Published: February 2024

Abstract
C12H12N2O8Mn, orthorhombic, Pbca (no. 61), a = 11.5651(15) Å, b = 9.4169(12) Å, c = 25.634(3) Å, V = 2791.7(6) Å3, Z = 8, Rgt
(F) = 0.0402, wRref
(F
2) = 0.1166, T = 296.15 K.
The effects of viscosity on the structure of shock waves in a van der Waals gas
Authors: Anand Raj Kumar , Singh Sewa 
Published: February 2024

Abstract
The structure of viscous shock-front has been investigated in a van der Waals gas between the boundary conditions for x = −ε and x = +ε considering the flow of a gas to be viscous and one-dimensional. The exact solutions for the flow parameters, fluid velocity, pressure, temperature, and change-in-entropy in the shock transition region have been found in view of the equation of state for van der Waals gases. The effects due to the coefficient of viscosity, shock strength, and nonidealness parameter have been analyzed on the structure and flow variable in the shock transition region. The results confirm that the thickness of shock-front increases with increasing value of the coefficient of viscosity and decreases with increasing value of the shock strength and nonidealness parameter of the gases.