bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to Accessing Congenital Heart Surgery in Low- and Middle-Income Countries: A Systematic Review
Authors: Cheng Samuel P.S. , Heo Kayoung , Joos Emilie , Vervoort Dominique , Joharifard Shahrzad 
Published: November 2023

Background Congenital heart disease (CHD) is the most common major congenital anomaly. Ninety percent of children with CHD are born in low- and middle-income countries (LMICs), where over 90% of patients lack access to necessary treatments. Reports on barriers to accessing CHD care are limited. Accordingly, it is difficult to design evidence-based interventions to increase access to congenital cardiac surgical care in LMICs. Objective We performed a qualitative systematic review to understand barriers to accessing congenital cardiac surgical care in LMICs. Methods We conducted a search of Ovid MEDLINE and CINAHL databases to identify relevant articles from January 2000 to May 2021. We then used a thematic analysis to summarize qualitative data into a framework of preoperative, perioperative, and postoperative barriers. Results Our search yielded 1,585 articles, of which 67 satisfied the inclusion criteria. Notable preoperative barriers included delayed diagnosis, insufficient caregiver education, financial constraints, difficulty reaching treatment centers, sociocultural stigma of CHD, sex-based discrimination of patients with CHD, and Indigeneity. Perioperative barriers included lack of hospital resources and workforce, need for prolonged hospitalization, and strained physician–patient relationships. Many patients faced barriers postoperatively and into adulthood due to a shortage of critical care resources, inadequate caregiver counseling and patient education, lack of follow-up, and debt from hospital bills and missed work. Conclusion Reducing neonatal and childhood mortality begins with recognizing barriers to accessing health care. Our systematic review identifies and classifies challenges in accessing CHD in LMICs and suggests solutions to major barriers.
Pelvic floor awareness in women with fibromyalgia: A controlled cross-sectional study
Authors: Yumusakhuylu Yasemin , Caglar Yagci Hanife , Senyurt Betül Ceyda , Icagasioglu Afitap , Pasin Özge , Erhan Belgin 
Published: November 2023

Objective: Fibromyalgia syndrome (FMS), is a painful syndrome of the musculoskeletal system with associating somatic symptoms which may include PF dysfunction (PFD). We aimed to investigate the patients’ awareness of pelvic floor (PF), the frequency, impact and severity of PFD in FMS and to investigate the effect of psychological state on PFD. Methods: Women with FMS and healthy controls enrolled to the study. Demographic data, urinary symptoms and questions regarding PF awareness asked. Fibromyalgia Impact Questionnaire, Beck Depression Questionnaire and Beck Anxiety Questionnaire were filled. SPSS 26 used for statistical analysis. Results: A total of 48 FMS and 48 healthy controls, with a mean age of 44 years were enrolled. The rate of UI in FMS group was significantly higher than the control group ( p < 0.001). The frequency of urinary incontinence (UI) was found 60% in FMS patients, and 25% in the control group. UI duration was significantly longer in the FMS group ( p = 0.013). There was a relation between the duration of UI and anxiety scores. As the duration of UI increases, the anxiety score also increases significantly ( r = 0.318; p = 0.043). The majority of the subjects, 25 (86.2%) patients from the FMS group and 11 (91.7%) patients from the control group, have not consulted any physician about UI complaints, therefore did not receive any treatment. Conclusion: PF awareness is quite low in the general population and in FMS. Studies should be carried out to inform the society about PFD and increase their awareness of the PF, and social responsibility projects should be prepared.
Comparing stroke rehabilitation inpatients and clinical trials eligibility criteria: A secondary chart review analysis revealing that most patients could have been excluded from rehabilitation trials based on comorbidity status
Authors: Nelson Michelle LA , Singh Hardeep , Nie Jason , MacDonald Shannon , Bayley Mark , Fortin Christian , Upshur Ross 
Published: November 2023

Background The generalizability of treatments examined in rehabilitation randomized controls trials (RCTs) partly depend on the similarity between trial subjects and a stroke rehabilitation inpatient population. The aim of this study was to determine the proportion of stroke rehabilitation inpatients that would have been eligible or ineligible to participate in published stroke RCTs. Methods This was a secondary analysis of chart review data collected as part of an independent quality improvement initiative. Data pertaining to the characteristics of stroke rehabilitation inpatients (e.g. age, cognitive impairment, previous stroke, comorbidities) were extracted from the medical charts of patients consecutively admitted to an inpatient stroke rehabilitation unit at a large urban rehabilitation hospital in Canada. Using the exclusion criteria categories of stroke RCTs identified from a systematic scoping review of 428 RCTs, we identified how many stroke rehabilitation inpatients would have been eligible or ineligible to participate in stroke RCTs based on their age, cognitive impairment, previous stroke and presence of comorbidities. Results In total, 110 stroke rehabilitation inpatients were included. Twenty-four percent of patients were 80 years of age or older, 84.5% had queries or concerns regarding patient cognitive abilities, 28.0% had a previous stroke, and 31.8% had a severe stroke. Stroke rehabilitation inpatients had six comorbidities on average. Based on these factors, most stroke rehabilitation inpatients could have been excluded from stroke RCTs, with cognitive impairment the most common RCT exclusion criteria. Conclusions Changes to the design of RCTs would support the development of clinical practice guidelines that reflect stroke rehabilitation inpatient characteristics, enhancing equity, diversity, and inclusion within samples and the generalizability of results.
Large monitoring datasets reveal high probabilities for intermittent occurrences of pesticides in European running waters
Authors: Herrmann Larissa Z. , Bub Sascha , Wolfram Jakob , Stehle Sebastian , Petschick Lara L. , Schulz Ralf 
Published: November 2023

AbstractMany studies have investigated short-term peak concentrations of pesticides in surface waters resulting from agricultural uses. However, we lack information to what extent pesticides reoccur over medium (> 4 days) and longer time periods (> 10 days). We use here large-scale pesticide monitoring data from across Europe (~ 15 mil. measurements, i.e., quantified concentrations in water at > 17,000 sites for 474 pesticide compounds) to evaluate the degree to which pesticides were not only detected once, but in sequences of a compound repeatedly quantified in the same area (0.015 km2) within 4–30 days. Reoccurrence was observed at ~ 18% of sites for > 76% of compounds, ~ 40% of which not a priori considered to chronically expose aquatic ecosystems. We calculated a probability of reoccurrence (POR) over medium-term (4–7 days) and long-term (8–30 days) time periods for ~ 360 pesticides. Relative PORs (ratio between long-term and medium-term POR) revealed three occurrence patterns: ephemeral, intermittent and permanent. While fungicides dominated intermittently occurring substances, aligning with application strategies and physico-chemical properties, neonicotinoids and legacy pesticides were among substances permanently occurring. The results of this study shed new light on previously underestimated longer-term occurrence of many pesticides in aquatic environments (35% of investigated substances occurring intermittently or permanently were previously not considered to pollute the aquatic environment chronically), entailing new challenges for chronic risk assessments and the evaluation of pesticide effects on aquatic biodiversity.
Job market polarization and American poverty
Authors: Siddique Abu Bakkar 
Published: November 2023

AbstractThe article posits that the puzzles of stagnating poverty rates amidst high growth and declining unemployment in the United States can be substantially explained by polarized job markets characterized by job quality and job distribution. In recent decades, there has been an increased number of poor-quality jobs and an unequal distribution of jobs in the developed world, particularly in the United States. I have calculated measures of uneven job distribution indices that account for the distribution of jobs across households. A higher value of the uneven job distribution indices implies that there are relatively large numbers of households with multiple employed people and households with no employed people. Similarly, poor-quality jobs are those jobs that do not offer full-time work. Two-way fixed-effect models estimate that higher uneven job distribution across households worsens aggregated poverty at the state level. Similarly, good-quality jobs help households escape poverty, whereas poor-quality jobs do not. This paper suggests that eradicating poverty requires the government to direct labor market policies to be tailored more toward distributing jobs from individuals to households and altering bad jobs into good jobs, rather than merely creating more jobs in the economy. This paper contributes by elaborating on relations of employment and poverty, addressing employment quality and distribution, and providing empirical evidence.
Exploring microproteins from various model organisms using the mip-mining database
Authors: Zhao Bowen , Zhao Jing , Wang Muyao , Guo Yangfan , Mehmood Aamir , Wang Weibin , Xiong Yi , Luo Shenggan , Wei Dong-Qing , Zhao Xin-Qing , Wang Yanjing 
Published: November 2023

AbstractMicroproteins, prevalent across all kingdoms of life, play a crucial role in cell physiology and human health. Although global gene transcription is widely explored and abundantly available, our understanding of microprotein functions using transcriptome data is still limited. To mitigate this problem, we present a database, Mip-mining (https://weilab.sjtu.edu.cn/mipmining/), underpinned by high-quality RNA-sequencing data exclusively aimed at analyzing microprotein functions. The Mip-mining hosts 336 sets of high-quality transcriptome data from 8626 samples and nine representative living organisms, including microorganisms, plants, animals, and humans, in our Mip-mining database. Our database specifically provides a focus on a range of diseases and environmental stress conditions, taking into account chemical, physical, biological, and diseases-related stresses. Comparatively, our platform enables customized analysis by inputting desired data sets with self-determined cutoff values. The practicality of Mip-mining is demonstrated by identifying essential microproteins in different species and revealing the importance of ATP15 in the acetic acid stress tolerance of budding yeast. We believe that Mip-mining will facilitate a greater understanding and application of microproteins in biotechnology. Moreover, it will be beneficial for designing therapeutic strategies under various biological conditions.
Sex-modified association between grip strength and mild cognitive impairment: a cross-sectional and follow-up study in rural China
Authors: Feng Wenjing , Chen Qian , Ma Mingfeng , Xu Jiahui , Guo Hui , Yuan Wei , Li Ruixue , Gao Hanshu , Gu Cuiying , Ma Yanan , Sun Zhaoqing , Tuo Nan , Zheng Liqiang 
Published: November 2023

Abstract
Background
The sex difference in the association between grip strength and mild cognitive impairment (MCI) remains controversial and unclear.

Methods
This is a part of a chronic disease cohort study conducted in rural areas, Fuxin, Liaoning Province, China. At the baseline survey, a total of 2633 participants aged 35- 85 were included in the cross-sectional study. Handgrip strength (HGS, kg) was measured by a dynamometer (Jamar +). MCI were assessed using the Chinese version of the Montreal Cognitive Assessment-Basic (MOCA-BC). Then, a total of 1667 cognitively normal individuals (NCs) were planed to follow up and to assess the incident MCI after two years. We used logistic regression to examine the association between HGS (as a continuous variable and quintiles) and MCI and analyzed the interaction between sex and HGS on MCI. Models stratified by sex were adjusted for demographic information (age, ethnicity, education, marital status, income, physical labor level), modifiable risk factors (body mass index, smoking, drinking) and disease history (hypertension, diabetes, dyslipidemia and coronary heart disease). Baseline MOCA-BC scores were additionally adjusted in the longitudinal study.

Results
In the cross-sectional study, participants were on average 56.6 ± 9.8 years, and 1713 (65.1%) were females. In the cohort study, 743 individuals were followed up with an average age of 55.9 ± 9.6 years, which included 530 (71.3%) females. The cumulative incidence of MCI over a two-year period was 17.1%. In the cross-sectional study, compared to the highest quintile of HGS, the lowest HGS was associated with higher risk of MCI in males (odds ratio [OR]: 2.66; 95% confidence interval [CI]: 1.54, 4.64) and females (OR: 1.70; 95% CI: 1.17, 2.49) with adjustment of potential confounding factors. In the cohort study, compared to the highest quintile of HGS, the lowest HGS was associated with an increased risk of incident MCI in females (OR: 3.93; 95% CI: 1.39, 13.01) but not in males (OR: 0.56; 95% CI: 0.11, 2.94, P for interaction = 0.015).

Conclusions
Lower grip strength is a risk factor for mild cognitive impairment and predicts a higher risk of MCI in females.
Driving the determinants of older people’s mental health in the context of urban resilience: a scoping review
Authors: Vahabi Sajad , Lak Azadeh , Panahi Niloofar 
Published: November 2023

Abstract
Background
Population aging is a pervasive phenomenon occurring rapidly worldwide, while sustainable development goals are considered the mental health among older adults.

Methods
To investigate the factors affecting mental health, we conducted a scoping review of the 47 papers published between 2015 and 2022 to explore various dimensions affecting older adults’ mental health.

Results
Our finding mirrors four dimensions of creating healthy and sustainable environments for older adults: person, place, processes, and resilience-related health in the living environment. The person dimension includes individual characteristics, attitudes and behaviors, and health status. The place dimension is divided into five categories: land use, access, physical form, public open spaces, and housing, while the process consists of the social, cultural, and economic environments. Resilience-related health dimension emphasizes the impact of natural and man-made disasters on older people’s mental health.

Discussion
These findings can provide policymakers insights into developing community-based environmental intervention strategies to promote mental health among older adults and support healthy and active aging.
Community transmission of SARS-CoV-2 during the Delta wave in New York City
Authors: Dai Katherine , Foerster Steffen , Vora Neil M. , Blaney Kathleen , Keeley Chris , Hendricks Lisa , Varma Jay K. , Long Theodore , Shaman Jeffrey , Pei Sen 
Published: November 2023

Abstract
Background
Understanding community transmission of SARS-CoV-2 variants of concern (VOCs) is critical for disease control in the post pandemic era. The Delta variant (B.1.617.2) emerged in late 2020 and became the dominant VOC globally in the summer of 2021. While the epidemiological features of the Delta variant have been extensively studied, how those characteristics shaped community transmission in urban settings remains poorly understood.

Methods
Using high-resolution contact tracing data and testing records, we analyze the transmission of SARS-CoV-2 during the Delta wave within New York City (NYC) from May 2021 to October 2021. We reconstruct transmission networks at the individual level and across 177 ZIP code areas, examine network structure and spatial spread patterns, and use statistical analysis to estimate the effects of factors associated with COVID-19 spread.

Results
We find considerable individual variations in reported contacts and secondary infections, consistent with the pre-Delta period. Compared with earlier waves, Delta-period has more frequent long-range transmission events across ZIP codes. Using socioeconomic, mobility and COVID-19 surveillance data at the ZIP code level, we find that a larger number of cumulative cases in a ZIP code area is associated with reduced within- and cross-ZIP code transmission and the number of visitors to each ZIP code is positively associated with the number of non-household infections identified through contact tracing and testing.

Conclusions
The Delta variant produced greater long-range spatial transmission across NYC ZIP code areas, likely caused by its increased transmissibility and elevated human mobility during the study period. Our findings highlight the potential role of population immunity in reducing transmission of VOCs. Quantifying variability of immunity is critical for identifying subpopulations susceptible to future VOCs. In addition, non-pharmaceutical interventions limiting human mobility likely reduced SARS-CoV-2 spread over successive pandemic waves and should be encouraged for reducing transmission of future VOCs.
Effectiveness of a scalable, remotely delivered stepped-care intervention to reduce symptoms of psychological distress among Polish migrant workers in the Netherlands: study protocol for the RESPOND randomised controlled trial
Authors: Roos Rinske , Witteveen Anke B. , Ayuso-Mateos José Luis , Barbui Corrado , Bryant Richard A. , Felez-Nobrega Mireia , Figueiredo Natasha , Kalisch Raffael , Haro Josep Maria , McDaid David , Mediavilla Roberto , Melchior Maria , Nicaise Pablo , Park A-La , Petri-Romão Papoula , Purgato Marianna , van Straten Annemieke , Tedeschi Federico , Underhill James , Sijbrandij Marit ,   the RESPOND Consortium
Published: November 2023

AbstractBackgroundThe COVID-19 pandemic has negatively affected the mental health of international migrant workers (IMWs). IMWs experience multiple barriers to accessing mental health care. Two scalable interventions developed by the World Health Organization (WHO) were adapted to address some of these barriers: Doing What Matters in times of stress (DWM), a guided self-help web application, and Problem Management Plus (PM +), a brief facilitator-led program to enhance coping skills. This study examines whether DWM and PM + remotely delivered as a stepped-care programme (DWM/PM +) is effective and cost-effective in reducing psychological distress, among Polish migrant workers with psychological distress living in the Netherlands.MethodsThe stepped-care DWM/PM + intervention will be tested in a two-arm, parallel-group, randomized controlled trial (RCT) among adult Polish migrant workers with self-reported psychological distress (Kessler Psychological Distress Scale; K10 > 15.9). Participants (n = 212) will be randomized into either the intervention group that receives DWM/PM + with psychological first aid (PFA) and care-as-usual (enhanced care-as-usual or eCAU), or into the control group that receives PFA and eCAU-only (1:1 allocation ratio). Baseline, 1-week post-DWM (week 7), 1-week post-PM + (week 13), and follow-up (week 21) self-reported assessments will be conducted. The primary outcome is psychological distress, assessed with the Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS). Secondary outcomes are self-reported symptoms of depression, anxiety, posttraumatic stress disorder (PTSD), resilience, quality of life, and cost-effectiveness. In a process evaluation, stakeholders’ views on barriers and facilitators to the implementation of DWM/PM + will be evaluated.DiscussionTo our knowledge, this is one of the first RCTs that combines two scalable, psychosocial WHO interventions into a stepped-care programme for migrant populations. If proven to be effective, this may bridge the mental health treatment gap IMWs experience.Trial registrationDutch trial register NL9630, 20/07/2021,https://www.onderzoekmetmensen.nl/en/trial/27052
Cardiovascular risk in Cuban adolescents and young adults with congenital adrenal hyperplasia
Authors: Espinosa Reyes Tania M. , Pesántez Velepucha Alba Katherine , Cabrera Rego Julio Oscar , Valdés Gómez Wendy , Domínguez Alonso Emma , Falhammar Henrik 
Published: November 2023

Abstract
Background
Hyperandrogenism and supraphysiologic glucocorticoid replacement may lead to subclinical atherosclerosis in people with congenital adrenal hyperplasia (CAH) and predispose the development of cardiovascular diseases from an early age.

Objectives
To determine if cardiometabolic risk factors and subclinical atherosclerosis are more frequent in patients with CAH due to 21-hydroxylase deficiency (21OHD) and if there is an association with clinical, hormonal and treatment of 21OHD.

Material and methods
A descriptive prospective cross-sectional study exploring clinical variables, biochemical, hormonal variables, endothelial dysfunction (flow-mediated dilation < 5%) and carotid intima media thickness (≥ 95 percentile in adolescents and ≥ 75 percentile in adults) and epicardial fat. Adolescents and young patients with 21OHD were compared with controls matched by age, sex, body mass index and Tanner stage.

Results
Forty four subjects (22 with CAH), 36 (82%) females, with a mean age of 17.1 ± 5.5 years (range 10–30 years) were included. Family history revealed diabetes, hypertension, and hypercholesterolemia with high frequencies in both groups. The blood pressure was similar in both groups. Blood glucose levels were lower and triglycerides higher in patient (both p < 0.01). Epicardial fat was similar between groups and in patients with CAH it was related to cholesterol levels ​​(r = 0.679, p < 0.01), time since CAH diagnosis (r = 0.462, p = 0.03) and glucocorticoid dose (r = 0.499, p = 0.04). Carotid intima media thickness (CIMT) had a tendency to be increased in patients (p = 0.07) and was directly related to 17-hydroxyprogesterone (r = 0.510, p = 0.018), diastolic blood pressure (r = 0.444, p = 0.04) and the homeostatic model assessment (HOMA) index (r = 0.507, p = 0.01). Endothelial dysfunction was not different between groups.

Conclusions
Some cardiometabolic risk factors were increased in patients with CAH and were associated with clinical, hormonal and treatment parameters of CAH. Cardiometabolic risk should be evaluated regularly in patients with CAH.