bluuebunny/crossref_metadata_2025_split huggingface dataset:
No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines
Authors: Yalcinkaya Ahmet , Cavalli Marco , Cederholm Axel , Aranda-Guillén Maribel , Behere Anish , Mildner Hedvig , Lakshmikanth Tadepally , Gonzalez Laura , Mugabo Constantin Habimana , Johnsson Anette , Ekwall Olov , Kämpe Olle , Bensing Sophie , Brodin Petter , Hallberg Pär , Wadelius Mia , Landegren Nils 
Published: February 2024

AbstractType I interferons act as gatekeepers against viral infection, and autoantibodies that neutralize these signaling molecules have been associated with COVID-19 severity and adverse reactions to the live-attenuated yellow fever vaccine. On this background, we sought to examine whether autoantibodies against type I interferons were associated with adverse events following COVID-19 vaccination. Our nationwide analysis suggests that type I interferon autoantibodies were not associated with adverse events after mRNA or viral-vector COVID-19 vaccines.
Cracking the code of seasonal seawater biofouling: enhanced biofouling control with quorum sensing inhibitor-functionalized membranes
Authors: Chen Chao , Yang Yu , Choo Kwang-Ho , Ng How Yong , Takizawa Satoshi , Hou Li-an 
Published: February 2024

AbstractMembrane biofouling poses an ongoing challenge in seawater reverse osmosis (SWRO) desalination. Here we delved into the impact of seasonal variations in microbial communities on membrane biofouling and innovatively fabricated quorum sensing inhibitors (acylase (AC) and methyl anthranilate (MA))-modified membranes to combat it. Results indicated that Proteobacteria dominated in seawater and membrane biofilm across all seasons, while other phyla varied seasonally. At the class level, the two leading bacteria on the membrane were Gamma- and Alphaproteobacteria, constituting 14–48% and 4–27%, respectively. Genera like Arcobacter, Vibrio, and Rhodobacteraceae were identified as keystone species that exhibited a significant positive correlation with extracellular polymeric substance (EPS) and biofilm formation, leading to a substantive reduction in membrane flux by 70 to 77%. The introduction of AC and MA inhibitors on the membrane suppressed keystone bacteria Rhodobacteraceae and Arcobacter and affected their metabolism, thereby significantly reducing EPS by 65–69% and 55–59%, respectively, and alleviating membrane flux decline by 30–32% and 18–22%, respectively, compared to the pristine membrane. These findings shed new light on the seasonal patterns of membrane biofouling and provide valuable insights into anti-biofouling strategies based on QS inhibition for collaborative biofilm formation.
Factors associated with the use of liquefied petroleum gas in Ghana vary at different stages of transition
Authors: Kar Abhishek , Tawiah Theresa , Graham Linnea , Owusu-Amankwah Georgette , Daouda Misbath , Malagutti Flavio , Chillrud Steve , Harned Erin E. , Iddrisu Seidu , Apraku Edward A. , Tetteh Richard , Awuni Sule , Jack Kelsey , Abubakari Sulemana W. , Jack Darby , Asante Kwaku P. 
Published: February 2024

AbstractClean-cooking transitions have the potential to generate large public health, environmental and societal gains for 2.6 billion people in the Global South. Here we use data from Ghana’s largest household energy survey (n = 7,389) to provide two main insights. First, regression analysis of 13 commonly cited socio-economic and demographic determinants of household fuel use indicates remarkably different relationships with clean-fuel use at different stages of the transition process. We propose a stage-based transition framework that can help inform the rollout of clean-cooking interventions. Second, we identify factors that are associated with the exclusive use of liquefied petroleum gas (LPG) using a statistically powered sample of exclusive LPG users (n = 693). We show that, all else equal, increases in wealth and urbanicity are not—contrary to conventional wisdom—associated with a transition from primary to exclusive LPG use. Whereas further research is needed to determine causality, our findings highlight the potential for more careful measurement, isolating each stage of the clean-cooking transition, to inform new insights and policy opportunities.
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns
Authors: Watson Emma V. , Lee Jake June-Koo , Gulhan Doga C. , Melloni Giorgio E. M. , Venev Sergey V. , Magesh Rayna Y. , Frederick Abdulrazak , Chiba Kunitoshi , Wooten Eric C. , Naxerova Kamila , Dekker Job , Park Peter J. , Elledge Stephen J. 
Published: February 2024

AbstractWhole chromosome and arm-level copy number alterations occur at high frequencies in tumors, but their selective advantages, if any, are poorly understood. Here, utilizing unbiased whole chromosome genetic screens combined with in vitro evolution to generate arm- and subarm-level events, we iteratively selected the fittest karyotypes from aneuploidized human renal and mammary epithelial cells. Proliferation-based karyotype selection in these epithelial lines modeled tissue-specific tumor aneuploidy patterns in patient cohorts in the absence of driver mutations. Hi-C-based translocation mapping revealed that arm-level events usually emerged in multiples of two via centromeric translocations and occurred more frequently in tetraploids than diploids, contributing to the increased diversity in evolving tetraploid populations. Isogenic clonal lineages enabled elucidation of pro-tumorigenic mechanisms associated with common copy number alterations, revealing Notch signaling potentiation as a driver of 1q gain in breast cancer. We propose that intrinsic, tissue-specific proliferative effects underlie tumor copy number patterns in cancer.
Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment
Authors: Greene Chris , Connolly Ruairi , Brennan Declan , Laffan Aoife , O’Keeffe Eoin , Zaporojan Lilia , O’Callaghan Jeffrey , Thomson Bennett , Connolly Emma , Argue Ruth , Meaney James F. M. , Martin-Loeches Ignacio , Long Aideen , Cheallaigh Cliona Ni , Conlon Niall , Doherty Colin P. , Campbell Matthew 
Published: February 2024

AbstractVascular disruption has been implicated in coronavirus disease 2019 (COVID-19) pathogenesis and may predispose to the neurological sequelae associated with long COVID, yet it is unclear how blood–brain barrier (BBB) function is affected in these conditions. Here we show that BBB disruption is evident during acute infection and in patients with long COVID with cognitive impairment, commonly referred to as brain fog. Using dynamic contrast-enhanced magnetic resonance imaging, we show BBB disruption in patients with long COVID-associated brain fog. Transcriptomic analysis of peripheral blood mononuclear cells revealed dysregulation of the coagulation system and a dampened adaptive immune response in individuals with brain fog. Accordingly, peripheral blood mononuclear cells showed increased adhesion to human brain endothelial cells in vitro, while exposure of brain endothelial cells to serum from patients with long COVID induced expression of inflammatory markers. Together, our data suggest that sustained systemic inflammation and persistent localized BBB dysfunction is a key feature of long COVID-associated brain fog.
Incidence and predictors of attrition among human immunodeficiency virus infected children on antiretroviral therapy in Amhara comprehensive specialized hospitals, Northwest Ethiopia, 2022: a retrospective cohort study
Authors: Zemariam Alemu Birara , Abebe Gebremeskel Kibret , Alamaw Addis Wondmagegn 
Published: February 2024

AbstractAttrition rate is higher in developing nations and it leftovers a major obstacle to enhance the benefits of therapy and achieve the 90–90–90 plan targets. Despite this fact, data on the incidence and its predictors of attrition among human immune deficiency virus infected children on antiretroviral therapy are limited in developing countries including Ethiopia especially after the test and treat strategy implemented. This study aimed to assess the incidence and predictors of attrition among human immune deficiency virus infected children on antiretroviral therapy in Amhara Comprehensive Specialized Hospitals, Northwest Ethiopia. A retrospective follow-up study was conducted among 359 children on ART from June 14, 2014, to June 14, 2022. Study participants were selected using simple random sampling method and the data were collected using Kobo Toolbox software and analysis was done by STATA version 14. Both bi-variable and multivariable Cox regression models were fitted to ascertain predictors. Lastly, an AHR with a 95% CI was computed and variables with a p-value of < 0.05 were took an account statistically key predictors of attrition. The overall incidence of attrition rate was 9.8 (95% CI 7.9, 11.9) per 100 PYO. Children having baseline hemoglobin < 10 mg/dl (AHR 3.94; 95% CI 2.32, 6.7), suboptimal adherence (AHR 1.96; 95% CI 1.23, 3.13), baseline opportunistic infection (AHR 1.8; 95% CI 1.17, 2.96), and children who had experienced drug side effects (AHR 8.3; 95% CI 4.93, 13.84) were established to be a significant predictors of attrition. The attrition rate was relatively high. Decreased hemoglobin, suboptimal adherence, presence of drug side effects and baseline opportunistic infection were predictors of attrition. Therefore, it is crucial to detect and give special emphasis to those identified predictors promptly.
Enantioselective synthesis of a two-fold inherently chiral molecular nanographene
Authors: Buendía Manuel , Fernández-García Jesús M. , Perles Josefina , Filippone Salvatore , Martín Nazario 
Published: February 2024

AbstractThe introduction and precise control of stereogenic elements in chemical structures is typically a challenging task. Most asymmetric methods require the presence of a heteroatom in the starting substrates acting as an anchor point for the successful transfer of chiral information. For this reason, compounds comprising only carbon atoms, such as optically active molecular nanographenes, are usually obtained as racemates, and isolated by chiral chromatographic separation. Here, we report an enantioselective strategy that uses three stereocontrolled synthetic steps to introduce and extend three different types of stereogenic elements, namely central, axial and helicoidal chirality, into a polycyclic aromatic structure. Thus, two chiral nanographene layers are covalently connected through a chiral triindane core. The final stereocontrolled graphitization Scholl reaction affords the formation of chiral nanographene units with remarkable enantiomeric excesses, high stereochemical stability and good chiroptical properties.
Microtubule-binding protein MAP1B regulates interstitial axon branching of cortical neurons via the tubulin tyrosination cycle
Authors: Ziak Jakub , Dorskind Joelle M , Trigg Brian , Sudarsanam Sriram , Jin Xinyu O , Hand Randal A , Kolodkin Alex L 
Published: February 2024

AbstractRegulation of directed axon guidance and branching during development is essential for the generation of neuronal networks. However, the molecular mechanisms that underlie interstitial (or collateral) axon branching in the mammalian brain remain unresolved. Here, we investigate interstitial axon branching in vivo using an approach for precise labeling of layer 2/3 callosal projection neurons (CPNs). This method allows for quantitative analysis of axonal morphology at high acuity and also manipulation of gene expression in well-defined temporal windows. We find that the GSK3β serine/threonine kinase promotes interstitial axon branching in layer 2/3 CPNs by releasing MAP1B-mediated inhibition of axon branching. Further, we find that the tubulin tyrosination cycle is a key downstream component of GSK3β/MAP1B signaling. These data suggest a cell-autonomous molecular regulation of cortical neuron axon morphology, in which GSK3β can release a MAP1B-mediated brake on interstitial axon branching upstream of the posttranslational tubulin code.
Impact of Physiological Fluctuations of Sex Hormones During the
Menstrual Cycle on Glucose Metabolism and the Gut Microbiota
Authors: Schieren Alina , Koch Sandra , Pecht Tal , Simon Marie-Christine 
Published: February 2024

AbstractDiabetes mellitus is one of the most prevalent chronic diseases. Previous studies
have shown differences in glucose metabolism between males and females.
Moreover, difficulties in medication adherence have been reported in females
with type 2 diabetes. These observations are believed to be caused by
fluctuations in sex hormone concentrations during the menstrual cycle.
Furthermore, gut microbiota is linked to female host metabolism and sex hormone
production. Understanding the interactions between fluctuating hormone
concentrations during the menstrual cycle, gut microbiota, and glucose
metabolism in humans is significant because of the increasing prevalence of
diabetes and the consequent need to expand preventive efforts. A literature
search was performed to determine and summarize the existing evidence, deduce
future research needs to maintain female health, and investigate the
relationship between the physiological menstrual cycle and glucose metabolism.
Studies from 1967 to 2020 have already examined the relationship between
variations during the menstrual cycle and glucose metabolism in healthy female
subjects using an oral-glucose tolerance test or intravenous glucose tolerance
test. However, the overall number of studies is rather small and the results are
contradictory, as some studies detected differences in glucose concentrations
depending on the different cycle phases, whereas others did not. Some studies
reported lower glucose levels in the follicular phase than in the luteal phase,
whereas another study detected the opposite. Data on gut microbiota in relation
to the menstrual cycle are limited. Conflicting results exist when examining the
effect of hormonal contraceptives on the gut microbiota and changes in the
course of the menstrual cycle. The results indicate that the menstrual cycle,
especially fluctuating sex hormones, might impact the gut microbiota
composition.The menstrual cycle may affect the gut microbiota composition and glucose
metabolism. These results indicate that glucose tolerance may be the greatest in
the follicular phase; however, further well-conducted studies are needed to
support this assumption.
Exploring the backward and forward linkages of production network in a developing country
Authors: Ahmad Imtiaz , Alvi Shahzad 
Published: February 2024

AbstractThis paper applies social network analysis (SNA) techniques to the input–output table in order to investigate the production network of Pakistan’s economy. Through different network measures, it identifies the sectors that exert significant direct and indirect impacts on other sectors. The findings reveal that, overall, sectors have weak forward linkages relative to backward linkages. The services sectors, particularly transportation and trade services, have the highest out-degree (a measure of forward linkages). In contrast, the manufacturing sectors demonstrate comparatively lower connectivity than the services sectors. The sectors of electricity, petroleum, and chemicals emerge as the most widely utilized inputs across various industries. Despite their relatively moderate immediate absorption in downstream industries, these sectors possess the potential to affect other industries indirectly. Considering the combined measures of network analysis, these sectors also emerge as the most crucial sectors in Pakistan’s production network. This suggests that enhancing efficiency in the energy, refining, and petrochemical industries will yield the highest economy-wide impact.
The mothers: contesting health-illness status and cultural authority in the age of AIDS
Authors: Gugliotti João Paulo , Miskolci Richard 
Published: February 2024

AbstractDespite the relevance and prevalence of research that produced knowledge about stigmatised groups and communities throughout the 1980s and 1990s, in the United States, studies that investigated the relationship between HIV/AIDS, intersectional stigma, and health-illness status among groups considered hegemonic are incipient—i.e., heterosexual, and white groups, who did not suffer stigma due to sexuality and race/colour, for example. In this study, such a gap is examined in order to observe the effects of stigma in non-exposed communities. Additionally, the article (i) explores the formation of a pioneering group of caregivers in New York City, the Mothers of Patients with AIDS (MPWA), created in 1986; and (ii) analyses narratives about health disease from a collective care agenda established by middle-aged and elderly mothers dealing with the challenges and needs of adult children and people with moderate and high degrees of dependence. This study is part of a larger project that investigated the emergence of non-profit organisations and gerontology care groups in the context of the HIV-AIDS epidemic in New York in the 1980s and 1990s. Documentary research was developed in the Florence Rush collection, made available by the Arthur and Elizabeth Schlesinger Library at Harvard University’s Radcliffe Institute for Advanced Study. The selected materials bring together qualitative empirical sources from reports, personal histories, and interviews conducted by Florence Rush and other mothers, social workers, and health professionals. As the results attest, the narratives produced by Florence Rush’s interlocutors during the AIDS health crisis make it possible to understand how social and cultural dynamics of recognising the disease did not result in autonomous, individual, and objective processes for exposing the pathological state. The strategic use of the term “cancer” instead of “AIDS” as an umbrella definition, and one less demarcated by aspects involving gender and sexual behaviour, evidenced the sociality of the illness. Conclusions show how negative representations were associated with AIDS—perceived as harmful, immoral, or deviant behaviours — and produced new meanings and demands among patients who feared stigmatising classifications in the midst of sexual panic until the commercial availability of the antiretroviral cocktail in 1997.
Vibrational state-specific nonadiabatic photodissociation dynamics of OCS+ via A2Π1/2 (ν1 0 ν3) states
Authors: Wang Yaling , Zhao Yunfan , Zhang Ning , Wang Wenxin , Hu Liru , Luo Chang , Yuan Daofu , Zhou Xiaoguo , Parker David H. , Yang Xueming , Wang Xingan 
Published: February 2024

The identification and analysis of quantum state-specific effects can significantly deepen our understanding of detailed photodissociation dynamics. Here, we report an experimental investigation on the vibrational state-mediated photodissociation of the OCS+ cation via the A2Π1/2 (ν1 0 ν3) states by using the velocity map ion imaging technique over the photolysis wavelength range of 263–294 nm. It was found that the electronically excited S+ product channel S+(2Du) + CO (X1Σ+) was significantly enhanced when the ν1 and ν3 vibrational modes were excited. Clear deviations in the branching ratios of the electronically excited S+ channel were observed when the vibrational modes ν1 and ν3 were selectively excited. The results reveal that vibrationally excited states play a vital role in influencing the nonadiabatic couplings in the photodissociation process.
Design and fabrication of a sensors-integrated silicon electrode for gap status monitoring in micro electrochemical machining
Authors: Zhu Yulan , Liu Guodong , Li Yong , Tong Hao 
Published: February 2024

Abstract
The monitoring of micro machining gap and the control of machining status within the gap have become bottlenecks in the research and development of micro electrochemical machining (ECM). General electrical signals are difficult to reflect the status of micro machining gap. Electrolytic products in micro machining gap are prone to precipitation and retention, leading to unstable material removal process. Micro ECM urgently requires gap status monitoring and feedback control. To realize gap status monitoring, a sensors-integrated silicon electrode, with a micro temperature sensor and a micro conductivity sensor on the silicon electrode near-front sidewall, is proposed innovatively in this study. Based on bulk silicon process and electroplating process, sensors-integrated silicon electrodes are designed and fabricated. Based on the signal processing system built for the temperature and conductivity sensor, the temperature and conductivity detection functions are verified and the sensors are calibrated. Micro ECM experiments with sensors-integrated silicon electrodes are carried out and micro holes with 200 μm depth are machined. For the conductivity sensor on the sensors-integrated silicon electrode, due to the affection of electrolytic environment, the function surface is contaminated and damaged, and the structural design needs to be further improved. For the temperature sensor, it is not affected by the electrolytic environment due to insulation-film’s protection, and reliable temperature monitoring is achieved in micro ECM. The detection results indicate that the temperature inside the machining gap has increased by 20 °C due to the electrochemical thermal effect and resistance thermal effect in micro ECM, and the temperature shows an increasing trend while machining depth increasing. The feasibility of process monitoring with sensors-integrated silicon electrode in micro ECM is preliminarily verified.
Exploring steric and electronic effects in tailoring lithium-ion solvation using engineered ether solvents through molecular dynamics simulations
Authors: Yuan Xueying , Du Linhan , Li Jipeng , Liu Zheng , Lu Diannan , Kong Xian 
Published: February 2024

Abstract
Lithium-metal batteries, owing to their remarkable energy density, represent a promising solution for future energy storage needs. However, the widespread adoption of lithium-metal batteries has been impeded by the inherent instability that exists between lithium metal and traditional liquid lithium electrolytes, initially designed for graphite anodes in lithium-ion batteries. Recent insights underscore the efficacy of electrolyte engineering as a strategic avenue to realize the potential of lithium-metal batteries. A notable approach involves the fluorination of solvent molecules, particularly those of the ether class. Nonetheless, a comprehensive understanding of the various factors governing solvent molecular design remains elusive. Here, we examine four solvents derived from 1,2-dimethoxylethane (DME) via molecular dynamics simulation. These solvents are engineered with the introduction of additional alkyl groups or through fluorination. We particularly scrutinize two critical facets: steric effects, arising from the incorporation of bulkier alkyl chains, and electronic effects, originating from fluorination. Our inquiry delves deeply into the stability, ion transport characteristics, and solvation behavior exhibited by these five distinct solvents. Our study underscores the profound impact of adjusting the steric and electronic attributes of solvent molecules on Li+ solvation behavior. This, in turn, influences the coordination strength and the mode of association between Li+ and solvation sites within the first solvation shell, providing key insights into the disparities in ion transport properties within electrolytes.