bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tropical Cyclones Related Wind Power on Oceanic Near‐Inertial Oscillations
Authors: Lin Sheng , Wang Yuntao , Zhang Wen‐Zhou , Ni Qin‐Biao , Chai Fei 
Published: November 2023

AbstractWind power input to oceanic near‐inertial oscillations (NIOs) plays a crucial role in sustaining the global ocean conveyor belt. However, the impact of tropical cyclones (TCs) on wind power input to NIOs, despite being the most vigorous atmospheric dynamics capable of exciting NIOs, is often overlooked in global estimations due to their transient nature and a lack of observations. Utilizing hourly wind and ocean current records, we quantified the wind power on NIOs induced by TCs from 1990 to 2019. Our findings reveal that the wind power on NIOs due to TCs is estimated to be between 0.028 and 0.065 TW, which accounts for a significant proportion, that is, 8%–17%, of that over the globe. This study highlights the importance of incorporating the wind power induced by TCs when estimating the global wind power on NIOs, as its impact is non‐negligible. Our findings contribute to a better understanding of the global energy balance by improving the estimation of wind power on NIOs.
Ice Supersaturation Variability in Cirrus Clouds: Role of Vertical Wind Speeds and Deposition Coefficients
Authors: Kärcher B. , Jensen E. J. , Pokrifka G. F. , Harrington J. Y. 
Published: November 2023

AbstractAircraft measurements reveal ice supersaturation statistics in cirrus (ISSs) with broad maxima around ice saturation and pronounced variance. In this study, processes shaping ISSs in midlatitude and tropical upper tropospheric conditions are systematically investigated. Water vapor deposition and sublimation of size‐resolved ice crystal populations are simulated in an air parcel framework. Mesoscale temperature fluctuations (MTFs) due to gravity waves force the temporal evolution of supersaturation. Various levels of background wave forcing and cirrus thickness are distinguished in stochastic ensemble simulations. Kinetic limitations to ice mass growth are brought about by supersaturation‐dependent deposition coefficients that represent efficient and inefficient growth modes as a function of ice crystal size. The simulations identify a wide range of deposition coefficients in cirrus, but most values stay above 0.01 such that kinetic limitations to water uptake remain moderate. Supersaturation quenching times are long, typically 0.5–2 hr. The wave forcing thus causes a remarkably large variability in ISSs and cirrus microphysical properties except in the thickest cirrus, producing ensemble‐mean ISSs in line with in‐situ measurements. ISS variance is controlled by MTFs and increases with decreasing cirrus integral radii. In comparison, the impact of ice crystal growth rates on ISSs is small. These results contribute to efforts directed at identifying and solving issues associated with ice‐supersaturated areas and non‐equilibrium cirrus physics in global models.
High Concentration of Atmospheric Sub‐3 nm Particles in Polluted Environment of Eastern China: New Particle Formation and Traffic Emission
Authors: Chen Liangduo , Qi Ximeng , Niu Guangdong , Li Yuanyuan , Liu Chong , Lai Shiyi , Liu Yuliang , Nie Wei , Yan Chao , Wang Jiaping , Chi Xuguang , Paasonen Pauli , Hussein Tareq , Lehtipalo Katrianne , Kerminen Veli‐Matti , Petäjä Tuukka , Kulmala Markku , Ding Aijun 
Published: November 2023

AbstractObservations of atmospheric sub‐3 nm particles are essential for understanding the initial stages of new particle formation (NPF) and the origin of aerosol particles. In this study, 3 years (2018–2020) of measurements of sub‐3 nm particles were conducted in the Yangtze River Delta (YRD) of eastern China. High concentrations of sub‐3 nm particles were observed, with number concentration in the range from 103 to 106 cm−3. During the daytime, the sub‐3 nm particle concentration was found to peak at around the noon, indicating strong photochemical nucleation processes. The formation rates of sub‐3 nm particles were high during the NPF event days, with an average value of 86 cm−3 s−1, and this rate was related to the sulfuric acid (SA) concentration. The particle growth rates below 3 nm were about 1–2 nm h−1, much lower than the growth rates of larger particles. At nighttime, sub‐3 nm particle concentrations remained relatively high (3 × 103 to 1.2 × 104 cm−3) and were related to the NOx concentration, suggesting traffic emission to be a significant source. The sub‐3 nm proxy was developed to estimate the contributions of NPF and traffic emission. During the daytime, 74.8% and 12.4% of the sub‐3 nm particles were estimated to originate from SA‐driven NPF and traffic emissions, respectively. However, other sources were estimated to contribute 61.8% of sub‐3 nm particles at nighttime, suggesting the formation mechanisms of sub‐3 nm particles are still unclear in this environment. Our study sheds more light on the characteristics and sources of sub‐3 nm particles in polluted environments.
Assessing for prenatal risk factors associated with infant neurologic morbidity using a multivariate analysis
Authors: Jain Samhita , Oltman Scott , Rogers Elizabeth , Ryckman Kelli , Petersen Mark , Baer Rebecca J. , Rand Larry , Piao Xianhua , Jelliffe-Pawlowski Laura 
Published: November 2023

Abstract
Objective
To characterize the biochemical and demographic profiles of pregnant people with maternal immune activation (MIA) and identify the prenatal characteristics associated with neurologic morbidity in offspring.

Study design
This was a retrospective cohort study of 602 mother-infant dyads with births between 2009 and 2010 in California. Multivariable logistic regression was used to build a MIA vulnerability profile including mid-pregnancy biochemical markers and maternal demographic characteristics, and its relationship with infant neurologic morbidity was examined.

Results
Of the 602 mother-infant dyads, 80 mothers and 61 infants had diagnoses suggestive of MIA and neurologic morbidity, respectively. Our model, including two demographic and seven biochemical characteristics, identified mothers with MIA with good performance (AUC:0.814; 95% CI:0.7–0.8). Three demographic and five inflammatory markers together identified 80% of infants with neurological morbidity (AUC:0.802, 95% CI:0.7–0.8).

Conclusion
Inflammatory environment in mothers with pre-existing risk factors like obesity, poverty, and prematurity renders offspring more susceptible to neurologic morbidities.
LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression
Authors: Chen Weiwei , Wang Fei , Yu Xinyuan , Qi Jingjing , Dong Hongliang , Cui Bingjie , Zhang Qian , Wu Yan , An Jiajia , Ni Na , Liu Cuilan , Han Yuchen , Zhang Shuo , Schmitt Clemens A. , Deng Jiong , Yu Yong , Du Jing 
Published: November 2023

AbstractNon-coding RNAs are responsible for oncogenesis and the development of stemness features, including multidrug resistance and metastasis, in various cancers. Expression of lncRNA MIR31HG in lung cancer tissues and peripheral sera of lung cancer patients were remarkably higher than that of healthy individuals and indicated a poor prognosis. Functional analysis showed that MIR31HG fosters stemness-associated malignant features of non-small cell lung cancer cells. Further mechanistic investigation revealed that MIR31HG modulated GLI2 expression via WDR5/MLL3/P300 complex-mediated H3K4me and H3K27Ace modification. In vivo MIR31HG repression with an antisense oligonucleotide attenuated tumor growth and distal organ metastasis, whereas MIR31HG promotion remarkably encouraged cellular invasion in lung and liver tissues. Our data suggested that MIR31HG is a potential diagnostic indicator and druggable therapeutic target to facilitate multiple strategic treatments for lung cancer patients.
Prevalence of medical emergency events in primary dental care within the UK
Authors: Sin Melissa , Edwards David , Currie Charlotte , Corbett Ian 
Published: November 2023

AbstractIntroduction Dental professionals have an ethical and legal obligation to diagnose and manage medical emergencies which may occur in primary dental care.Aims and objectives To investigate the prevalence of medical emergencies in UK primary dental care and explore the medical emergency training needs of UK primary dental care professionals.Design and setting Cross-sectional survey, targeting dentists, dental hygienists and dental therapists across the UK working within primary dental care.Materials and methods An online survey was distributed via dental society mailing lists, social media groups and a dental conference. The questionnaire consisted of participants demographics and training in, prevalence of and confidence surrounding medical emergencies.Results Respondents (n = 400) were dentists (55.8%), dental hygienists/therapists (38.8%) and specialists (5.5%). Most participants received basic life support training (62%) in 2019, before COVID-19. The most common medical emergencies were syncope, non-specific collapse and hypoglycaemia, being encountered every 1.59, 1.64 and 8.26 years, respectively. The preferred method for medical emergency training was practical based, with more training in administering emergency drugs and equipment identified as a training need.Conclusion Dental professionals will encounter medical emergencies in primary dental care every 1-2 years and are therefore not uncommon.
Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer
Authors: Quixabeira D. C. A. , Pakola S. , Jirovec E. , Havunen R. , Basnet S. , Santos J. M. , Kudling T. V. , Clubb J. H. A. , Haybout L. , Arias V. , Grönberg-Vähä-Koskela S. , Cervera-Carrascon V. , Kerkelä E. , Pasanen A. , Anttila M. , Tapper J. , Kanerva A. , Hemminki A. 
Published: November 2023

AbstractDespite good results in the treatment of hematological malignancies, Natural killer (NK) cells have shown limited effectiveness in solid tumors, such as ovarian cancer (OvCa). Here, we assessed the potential of an oncolytic adenovirus expressing a variant interleukin-2 (vIL-2) cytokine, Ad5/3-E2F-d24-vIL2 (vIL-2 virus), also known as TILT-452, to enhance NK cell therapy efficacy in human OvCa ex vivo. Human OvCa surgical specimens were processed into single-cell suspensions and NK cells were expanded from healthy blood donors. OvCa sample digests were co-cultured ex vivo with NK cells and vIL-2 virus and cancer cell killing potential assessed in real time through cell impedance measurement. Proposed therapeutic combination was evaluated in vivo with an OvCa patient-derived xenograft (PDX) in mice. Addition of vIL-2 virus significantly enhanced NK cell therapy killing potential in treated OvCa co-cultures. Similarly, vIL-2 virus in combination with NK cell therapy promoted the best in vivo OvCa tumor control. Mechanistically, vIL-2 virus induced higher percentages of granzyme B in NK cells, and CD8+ T cells, while T regulatory cell proportions remained comparable to NK cell monotherapy in vivo. Ad5/3-E2F-d24-vIL2 virus treatment represents a promising strategy to boost adoptive NK cell therapeutic effect in human OvCa.
SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway
Authors: Patra Srimanta , Singh Amruta , Praharaj Prakash P. , Mohanta Nitish K. , Jena Mrutyunjay , Patro Birija S. , Abusharha Ali , Patil Shankargouda , Bhutia Sujit K. 
Published: November 2023

AbstractSIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, is downregulated in oral cancer cells. Non-apoptotic doses of cisplatin (CDDP) downregulate SIRT1 expression advocating the mechanism of drug resistance. SIRT1 downregulation orchestrates inhibition of DNM1L-mediated mitochondrial fission, subsequently leading to the formation of hyperfused mitochondrial networks. The hyperfused mitochondrial networks preserve the release of cytochrome C (CYCS) by stabilizing the mitochondrial inner membrane cristae (formation of mitochondrial nucleoid clustering mimicking mito-bulb like structures) and reducing the generation of mitochondrial superoxide to inhibit apoptosis. Overexpression of SIRT1 reverses the mitochondrial hyperfusion by initiating DNM1L-regulated mitochondrial fission. In the overexpressed cells, inhibition of mitochondrial hyperfusion and nucleoid clustering (mito-bulbs) facilitates the cytoplasmic release of CYCS along with an enhanced generation of mitochondrial superoxide for the subsequent induction of apoptosis. Further, low-dose priming with gallic acid (GA), a bio-active SIRT1 activator, nullifies CDDP-mediated apoptosis inhibition by suppressing mitochondrial hyperfusion. In this setting, SIRT1 knockdown hinders apoptosis activation in GA-primed oral cancer cells. Similarly, SIRT1 overexpression in the CDDP resistance oral cancer-derived polyploid giant cancer cells (PGCCs) re-sensitizes the cells to apoptosis. Interestingly, synergistically treated with CDDP, GA induces apoptosis in the PGCCs by inhibiting mitochondrial hyperfusion.
Electronic landscape of kagome superconductors AV3Sb5 (A = K, Rb, Cs) from angle-resolved photoemission spectroscopy
Authors: Hu Yong , Wu Xianxin , Schnyder Andreas P. , Shi Ming 
Published: November 2023

AbstractThe recently discovered layered kagome superconductors AV3Sb5 (A = K, Rb, Cs) have garnered significant attention, as they exhibit an intriguing combination of superconductivity, charge density wave (CDW) order, and nontrivial band topology. As such, these kagome systems serve as an exceptional quantum platform for investigating the intricate interplay between electron correlation effects, geometric frustration, and topological electronic structure. A comprehensive understanding of the underlying electronic structure is crucial for unveiling the nature and origin of the CDW order, as well as determining the electron pairing symmetry in the kagome superconductors. In this review, we present a concise survey of the electronic properties of AV3Sb5, with a particular focus on the insights derived from angle-resolved photoemission spectroscopy (ARPES). Through the lens of ARPES, we shed light on the electronic characteristics of the kagome superconductors AV3Sb5, which will pave the way for exciting new research frontiers in kagome-related physics.
MMLKG: Knowledge Graph for Mathematical Definitions, Statements and Proofs
Authors: Tomaszuk Dominik , Szeremeta Łukasz , Korniłowicz Artur 
Published: November 2023

AbstractNowadays, Knowledge Graphs (KGs) are important and developing in different areas. However, there is a lack of genuinely interoperable datasets representing mathematics that allow for information exchange between datasets in the Web ecosystem. In this paper, we address this matter based on the Mizar Mathematical Library (MML), a collection of articles written in the Mizar language. MML includes definitions and theorems with proofs to which authors can easily refer from newly written Mizar articles. However, extracting information directly from Mizar scripts by external projects is not very straightforward. Therefore, we propose a new data storage and retrieval approach based on the Knowledge Organization System (KOS) model and the KG concept that provides a way to organize and access knowledge. We present Mizar Mathematical Library Knowledge Graph (MMLKG), a thesaurus for describing mathematical objects. MMLKG supports semantic interoperability and allows linking data from different sources, e.g., Wikidata. Moreover, it satisfies the FAIR data principles. The data is publicly available via a Cypher endpoint.
A dataset of branched fatty acid esters of hydroxy fatty acids diversity in foods
Authors: An Na , Wang Yu , He Dong-Xiao , Mei Peng-Cheng , Zhu Quan-Fei , Feng Yu-Qi 
Published: November 2023

AbstractBranched fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of bioactive lipids that show therapeutic potential for diabetes, anti-cancer and inflammation. These FAHFAs can be obtained through dietary intake, potentially improving human health. However, there is currently inadequate knowledge regarding the presence and variety of FAHFAs in different foods. Herein, we profile FAHFAs from 12 typical food samples and 4 medicinal food samples with the aid of our previous established chemical isotope labeling-assisted liquid chromatography-mass spectrometry method and build a comprehensive dataset of FAHFA diversity. The dataset comprised a total of 1207 regioisomers belonging to 298 different families, with over 100 families being newly discovered for the first time. Therefore, our findings contribute valuable insights into the molecular diversity and presence of FAHFA in a range of foods. This dataset serves as a foundation for further exploration of the nutritional and medicinal functions of FAHFAs.
Adsorption characteristics of nickel (II) from aqueous solutions by Zeolite Scony Mobile-5 (ZSM-5) incorporated in sodium alginate beads
Authors: Hellal Mohamed S. , Rashad Ahmed M. , Kadimpati Kishore K. , Attia Sayed K. , Fawzy Mariam E. 
Published: November 2023

AbstractNickel, a prevalent metal in the ecosystem, is released into the environment through various anthropogenic activities, leading to adverse effects. This research explored utilizing zeolite scony mobile-5 (ZSM-5) nanoparticles encapsulated in sodium alginate (SA) for nickel (II) removal from aqueous solutions. The adsorption characteristics of SA/ZSM-5 were examined concerning contact duration, initial metal ion concentration, pH level, temperature, and sorbent dosage. The findings revealed that a rising pH reduced Ni (II) uptake by the sorbent while increasing the Ni (II) concentration from 25 to 100 mg L−1 led to a decrease in removal percentage from 91 to 80% under optimal conditions. Furthermore, as sorbent dosage increased from 4 to 16 g L−1, uptake capacity declined from 9.972 to 1.55 mg g−1. Concurrently, SA/ZSM-5 beads' Ni (II) sorption capacity decreased from 96.12 to 59.14% with a temperature increase ranging from 25 to 55 °C. The Ni (II) sorption data on SA/ZSM-5 beads are aptly represented by Langmuir and Freundlich equilibrium isotherm models. Moreover, a second-order kinetic model characterizes the adsorption kinetics of Ni (II) on the SA/ZSM-5 beads. A negative free energy change (ΔG°) demonstrates that the process is both viable and spontaneous. The negative enthalpy values indicate an exothermic nature at the solid–liquid interface while negative entropy values suggest a decrease in randomness. In conclusion, this novel adsorbent exhibits promise for removing nickel from aqueous solutions and could potentially be employed in small-scale industries under similar conditions.
Risk prediction of inappropriate implantable cardioverter-defibrillator therapy using machine learning
Authors: Tateishi Ryo , Suzuki Makoto , Shimizu Masato , Shimada Hiroshi , Tsunoda Takahiro , Miyazaki Hiroko , Misu Yoshiki , Yamakami Yosuke , Yamaguchi Masao , Kato Nobutaka , Isshiki Ami , Kimura Shigeki , Fujii Hiroyuki , Nishizaki Mitsuhiro , Sasano Tetsuo 
Published: November 2023

AbstractWe aimed to develop machine learning-based predictive models for identifying inappropriate implantable cardioverter-defibrillator (ICD) therapy. Our study included 182 consecutive cases (average age 62.2 ± 4.5 years, 169 men) and employed 14 non-deep learning models for prediction (hold-out method). These models utilized selected electrocardiogram parameters and clinical features collected after ICD implantation. From the feature importance analysis of the best ML model, we established easily calculable scores. Among the patients, 25 (13.7%) experienced inappropriate therapy, and we identified 16 significant predictors. Using recursive feature elimination with cross-validation, we reduced the features to six with high feature importance: history of atrial arrhythmia (Atr-arrhythm), ischemic cardiomyopathy (ICM), absence of diabetes mellitus (DM), lack of cardiac resynchronization therapy (CRT), V3 ST level at J point (V3 STJ), and V5 R-wave amplitudes (V5R amp). The extra-trees classifier yielded the highest area under receiver operating characteristics curve (AUROC; 0.869 on test data). Thus, the Cardi35 score was defined as [+ 5.5*Atr-arrhythm − 1.5*CRT + 1.0*V3STJ + 1.0*V5R − 1.0*ICM − 0.5*DM], which demonstrated a hazard ratio of 1.62 (P < 0.001). A cut-off value of the score + 5.5 showed high AUROC (0.826). The ML approach can yield a robust prediction model, and the Cardi35 score was a convenient predictor for inappropriate therapy.
Optimizing thermoelectric performance of carbon-doped h-BN monolayers through tuning carrier concentrations and magnetic field
Authors: Behzad Somayeh , Chegel Raad 
Published: November 2023

AbstractThe thermoelectric properties of carbon-doped monolayer hexagonal boron nitride (h-BN) are studied using a tight-binding model employing Green function approach and the Kubo formalism. Accurate tight-binding parameters are obtained to achieve excellent fitting with Density Functional Theory results for doped h-BN structures with impurity type and concentration. The influence of carbon doping on the electronic properties, electrical conductivity, and heat capacity of h-BN is studied, especially under an applied magnetic field. Electronic properties are significantly altered by doping type, concentration, and magnetic field due to subband splitting, merging of adjacent subbands, and band gap reduction. These modifications influence the number, location, and magnitude of DOS peaks, generating extra peaks inside the band gap region. Heat capacity displays pronounced dependence on both magnetic field and impurity concentration, exhibiting higher intensity at lower dopant levels. Electrical conductivity is increased by double carbon doping compared to single doping, but is reduced at high magnetic fields because of high carrier scattering. The electronic figure of merit ZT increases with lower impurity concentration and is higher for CB versus CN doping at a given field strength. The power factor can be improved by increasing magnetic field and decreasing doping concentration. In summary, controlling doping and magnetic field demonstrates the ability to effectively engineer the thermoelectric properties of monolayer h-BN.
Energy transfer through third‐grade fluid flow across an inclined stretching sheet subject to thermal radiation and Lorentz force
Authors: Hamad Najiba Hasan , Bilal Muhammad , Ali Aatif , Eldin Sayed M. , Sharaf Mohamed , Rahman Mati Ur 
Published: November 2023

AbstractThe heat and mass transfer through the third grade fluid (TGF) flow over an inclined elongating sheet with the consequences of magnetic field and chemical reaction is reported. The impact of activation energy, heat source/sink, and thermal radiation is considered on the TGF flow. Fluid that demonstrate non-Newtonian (NN) properties such as shear thickening, shear thinning, and normal stresses despite the fact that the boundary is inflexible is known as TGF. It also has viscous elastic fluid properties. In the proposed model, the TGF model is designed in form of nonlinear coupled partial differential equations (PDEs). Before employing the numerical package bvp4c, the system of coupled equations are reduced into non-dimensional form. The finite-difference code bvp4c, in particular, executes the Lobatto three-stage IIIa formula. The impacts of flow constraints on velocity field, energy profile, Nusselt number and skin friction are displayed through Tables and Figures. For validity of the results, the numerical comparison with the published study is performed through Table. From graphical results, it can be perceived that the fluid velocity enriches with the variation of TGF factor and Richardson number. The heat source parameter operational as a heating mediator for the flow system, its influence enhances the fluid temperature.