bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single port robot‐assisted pyeloplasty: An early comparative outcomes analysis
Authors: Ditonno Francesco , Franco Antonio , Manfredi Celeste , Feng Carol L. , Bologna Eugenio , Licari Leslie Claire , Olweny Ephrem O. , Vourganti Srinivas , Cherullo Edward E. , Chow Alexander K. , Autorino Riccardo 
Published: February 2024

AbstractBackgroundThe treatment paradigm for ureteropelvic junction obstruction (UPJO) has shifted towards minimally invasive pyeloplasty. A comparison Single Port (SP) and Multi Port (MP) robot‐assisted pyeloplasty (RAP) was performed.MethodsData from consecutive patients undergoing SP RAP or MP RAP between January 2021 and September 2023 were collected and analysed. Co‐primary outcomes were length of stay (LOS), Defense and Veterans Pain Rating Scale (DVPRS), and narcotic dose. The choice of the robotic system depended on the surgeon's preference and availability of a specific robotic platform.ResultsA total of 10 SP RAPs and 12 MP RAPs were identified. SP RAP patients were significantly younger [23 years (20–34)] than MP RAP [42 years (35.5–47.5), p < 0.01]. No difference in terms of OT (p = 0.6), LOS (p = 0.1), DVPRS (p = 0.2) and narcotic dose (p = 0.1) between the two groups was observed.ConclusionsSP RAP can be implemented without compromising surgical outcomes and potentially offering some clinical advantages.
In silico Approach for Design, Synthesis and Biological Evaluation of Tioxanthone Derivatives as Potential Anticancer Agents
Authors: Hermawan Faris , Jumina Jumina , Pranowo Harno Dwi , Sholikhah Eti Nurwening , Ernawati Teni , Azminah Azminah 
Published: February 2024

AbstractThe investigation of thioxanthones involved molecular docking, molecular dynamics simulation, synthesis, and evaluation of their potential as anticancer agents. Molecular docking analyses indicated that 2,4‐dichloro‐1,3‐dihydroxythioxanthone and 2,4‐dibromo‐1,3‐dihydroxythioxanthone had lower binding energies and 4‐bromo‐1,3‐dihydroxythioxanthone had the similar binding energy compared to erlotinib. In 50 ns molecular dynamics simulation, 2,4‐dichloro‐1,3‐dihydroxythioxanthone and 2,4‐dibromo‐1,3‐dihydroxythioxanthone complex exhibited more stability than 4‐bromo‐1,3‐dihydroxythioxanthone and erlotinib, while it had similar stability with doxorubicin. These compounds comply the Lipinski's rule parameters and the minimum required parameters of ADMET. The evaluated anticancer activity of 2,4‐dichloro‐1,3‐dihydroxythioxanthone and 2,4‐dibromo‐1,3‐dihydroxythioxanthone revealed them inactive against cervical cancer (HeLa) and colorectal cancer (WiDr) with IC50 more than 100 μM, however was moderate activity toward breast cancer (T47D) and lung cancer (A549). The selectivity index (SI) values of those compounds (7.71–148.4) passed the parameter SI. Based on these findings, 2,4‐dibromo‐1,3‐dihydroxythioxanthone was the most promising anticancer candidate for T47D cancer cell.
Efficient Protocol for the Synthesis of N‐Phosphorodiamidate Peptidomimetics
Authors: Hampasagarada Alavandimat Nanda , Venkata Sureshbabu Vommina 
Published: February 2024

AbstractPhosphoryl peptidomimetics represent a novel class of peptide analogs that have garnered attention due to their unique synthetic pathways. Employing a combination of Tf2O and pyridine, the amino acid phosphoryl diester transforms into a phosphorodiamidate compound. This conversion involves activating one of the ester moieties, yielding a good product. This protocol is characterized by its straightforward and comprehensive approach, making it a notable advancement in the chemistry of peptidomimetics.
Dimension Evolution of Self‐Assembled Organic Microcrystal for Laser and Polarization‐Rotation Function
Authors: Yao Yinan , Zhao Yong Sheng , Guan Lunhui 
Published: February 2024

AbstractMultidimensional integrated micro/nanostructures are vitally important for the implementation of versatile photonic functionalities, whereas current material structures still suffer undesired surface defects and contaminations in either multistep micro/nanofabrications or extreme synthetic conditions. Herein, the dimension evolution of organic self‐assembled structures 2D microrings and 3D microhelixes for multidimensional photonic devices is realized via a protic/aprotic solvent‐directed molecular assembly method based on a multiaxial confined‐assisted growth mechanism. The 2D microrings with consummate circle boundaries and molecular‐smooth surfaces function as high‐quality whispering‐gallery‐mode microcavities for dual‐wavelength energy‐influence‐dependent switchable lasing. Moreover, the 3D microhelixes with smooth surfaces and natural twistable characteristics act as active photon‐transport materials and polarization rotators. These results will broaden the horizon of constructing multidimensional microstructures for integrated photonic circuits.
Effective Energy Storage Performance Derived from 3D Porous Dendrimer Architecture Metal Phosphides//Metal Nitride‐Sulfides
Authors: Swain Nilimapriyadarsini , Balasubramaniam Saravanakumar , Ramadoss Ananthakumar 
Published: February 2024

AbstractThe present work addresses the limitations by fabricating a wide range of negative electrodes, including metal nitrides/sulfides on a 3D bimetallic conductive porous network (3D‐Ni and 3D‐NiCo) via a dynamic hydrogen bubble template (DHBT) method followed by vapour phase growth (VPG) process. Among the prepared negative electrodes, the 3D‐Fe3S4‐Fe4N/NiCo nanostructure demonstrates an impressive specific capacitance (Cs) of 1125 F g−1 (2475 mF cm−2) at 1 A g−1 with 80% capacitance retention over 5000 cycles. Similarly, a 3D‐Mn3P nanostructured positive electrode fabricated via electrodeposition followed by a phosphorization process exhibits a maximum specific capacity (Cg) of 923.04 C g−1 (1846.08 mF cm−2) at 1 A g−1 with 80% stability. A 3D‐Mn3P/Ni//3D‐Fe3S4‐Fe4N/NiCo supercapattery is also assembled, and it shows a notable CS of 151 F g−1 at 1 A g−1, as well as a high energy density (ED) of 51 Wh kg−1,a power density (PD) of 782.57 W kg−1 and a capacitance efficiency of 76% over 10 000 cycles. This may be ascribed to the use of a bimetallic 3D porous conductive template and the attachment of transition metal sulfide and nitride. The development of negative electrodes and supercapattery devices is greatly aided by this exploration of novel synthesis techniques and material choice.
In Situ Polymerization of Hydrogel Electrolyte on Electrodes Enabling the Flexible All‐Hydrogel Supercapacitors with Low‐Temperature Adaptability
Authors: Zhang Yijing , Sun Yue , Nan Jingya , Yang Fusheng , Wang Zihao , Li Yuxi , Wang Chuchu , Chu Fuxiang , Liu Yupeng , Wang Chunpeng 
Published: February 2024

AbstractAll‐hydrogel supercapacitors are emerging as promising power sources for next‐generation wearable electronics due to their intrinsic mechanical flexibility, eco‐friendliness, and enhanced safety. However, the insufficient interfacial adhesion between the electrode and electrolyte and the frozen hydrogel matrices at subzero temperatures largely limit the practical applications of all‐hydrogel supercapacitors. Here, an all‐hydrogel supercapacitor is reported with robust interfacial contact and anti‐freezing property, fabricated by in situ polymerizing hydrogel electrolyte onto hydrogel electrodes. The robust interfacial adhesion is developed by the synergistic effect of a tough hydrogel matrix and topological entanglements. Meanwhile, the incorporation of zinc chloride (ZnCl2) in the hydrogel electrolyte prevents the freezing of water solvents and endows the all‐hydrogel supercapacitor with mechanical flexibility and fatigue resistance across a wide temperature range of 20 °C to –60 °C. Such all‐hydrogel supercapacitor demonstrates satisfactory low‐temperature electrochemical performance, delivering a high energy density of 11 mWh cm−2 and excellent cycling stability with a capacitance retention of 90% over 10000 cycles at −40 °C. Notably, the fabricated all‐hydrogel supercapacitor can endure dynamic deformations and operate well under 2000 tension cycles even at −40 °C, without experiencing delamination and electrochemical failure. This work offers a promising strategy for flexible energy storage devices with low‐temperature adaptability.
Bioactive Metal–Organic Frameworks as a Distinctive Platform to Diagnosis and Treat Vascular Diseases
Authors: Liu Wen , Li Ying , Wang Yuanchao , Feng Yakai 
Published: February 2024

AbstractVascular diseases (VDs) pose the leading threat worldwide due to high morbidity and mortality. The detection of VDs is commonly dependent on individual signs, which limits the accuracy and timeliness of therapies, especially for asymptomatic patients in clinical management. Therefore, more effective early diagnosis and lesion‐targeted treatments remain a pressing clinical need. Metal–organic frameworks (MOFs) are porous crystalline materials formed by the coordination of inorganic metal ions and organic ligands. Due to their unique high specific surface area, structural flexibility, and functional versatility, MOFs are recognized as highly promising candidates for diagnostic and therapeutic applications in the field of VDs. In this review, the potential of MOFs to act as biosensors, contrast agents, artificial nanozymes, and multifunctional therapeutic agents in the diagnosis and treatment of VDs from the clinical perspective, highlighting the integration between clinical methods with MOFs is generalized. At the same time, multidisciplinary cooperation from chemistry, physics, biology, and medicine to promote the substantial commercial transformation of MOFs in tackling VDs is called for.
Strong Interface Coupling Enables Stability of Amorphous Meta‐Stable State in CoS/Ni3S2 for Efficient Oxygen Evolution
Authors: Luo Wei , Yu Yanli , Wu Yucheng , Wang Wenbin , Jiang Yimin , Shen Wei , He Rongxing , Su Wei , Li Ming 
Published: February 2024

AbstractRational design of heterostructure catalysts through phase engineering strategy plays a critical role in heightening the electrocatalytic performance of catalysts. Herein, a novel amorphous/crystalline (a/c) heterostructure (a‐CoS/Ni3S2) is manufactured by a facile hydrothermal sulfurization method. Strikingly, the interface coupling between amorphous phase (a‐CoS) and crystalline phase (Ni3S2) in a‐CoS/Ni3S2 is much stronger than that between crystalline phase (c‐CoS) and crystalline phase (Ni3S2) in crystalline/crystalline (c/c) heterostructure (c‐CoS/Ni3S2) as control sample, which makes the meta‐stable amorphous structure more stable. Meanwhile, a‐CoS/Ni3S2 has more S vacancies (Sv) than c‐CoS/Ni3S2 because of the presence of an amorphous phase. Eventually, for the oxygen evolution reaction (OER), the a‐CoS/Ni3S2 exhibits a significantly lower overpotential of 192 mV at 10 mA cm−2 compared to the c‐CoS/Ni3S2 (242 mV). An exceptionally low cell voltage of 1.51 V is required to achieve a current density of 50 mA cm−2 for overall water splitting in the assembled cell (a‐CoS/Ni3S2 || Pt/C). Theoretical calculations reveal that more charges transfer from a‐CoS to Ni3S2 in a‐CoS/Ni3S2 than in c‐CoS/Ni3S2, which promotes the enhancement of OER activity. This work will bring into play a fabrication strategy of a/c catalysts and the understanding of the catalytic mechanism of a/c heterostructures.
Physicochemical Characterization of Vitis vinifera Pruning Shots from Mendoza, Argentina: Extraction of Lignocellulosic Products
Authors: Giaroli María Carolina , Pérez Claudio Javier , Vega Gustavo Alberto , Ciolino Andrés Eduardo , Ninago Mario Daniel 
Published: February 2024

AbstractFor the first time, a complete physicochemical characterization of pruning residues from red grape varieties Cabernet Sauvignon (CSPR) and Malbec (MPR) from Mendoza, Argentina is reported. In addition, the extraction of lignocellulosic material by using an environmentally friendly methodology is reported, yielding 13.33 wt% for CSPR and 8.08 wt% for MPR. According to laser diffraction analysis (LD), the particle‐size distribution is similar for both varieties. Fourier transform‐infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), scanning‐electron microscopy (SEM), optical microscopy (OM), and X‐rays diffraction (XRD) show the presence of lignin and cellulose in both samples. It may be concluded that vine shoots are an inexpensive and widely available source to obtain lignin and cellulose for multiple purposes, such as composites and blends.
Modification, Structure Identification, and Biological Activities of Phosphorylated Polysaccharides: A Review
Authors: Gao Yuchao , Liu Zechao , Dai Shasha , Zhao Jianduo , Guo Yibo , Cai Xu , Xue Hongkun 
Published: February 2024

AbstractPolysaccharides are a kind of biological macromolecule, which widely exists in plants, fungi, animals, microorganisms, and other organisms. Polysaccharides exhibit various biological activities such as immunological regulation, antioxidation, antitumor, antiinflammatory, regulating intestinal flora, and protecting liver. These biological activities depend on their structure and physicochemical properties including monosaccharide composition, molecular weight (Mw), spatial configuration, etc. However, biological activities of polysaccharides are hardly comparable to synthetic drugs due to their inherent physicochemical properties. Therefore, structural modification of polysaccharides is an effective way to enhance their biological activities and promote the presentation of bioactivity. At present, phosphorylation modification is a common chemical modification method, which can effectively improve the biological activities of polysaccharides. However, there are limited reports on the synthesis, structure identification, and biological activities of phosphorylated polysaccharides. In view of this, the synthesis methods, structure identification methods, and biological activities of phosphorylated polysaccharides are reviewed in this paper. The findings can provide useful guidance for the research, production, and application of phosphorylated polysaccharides in functional foods and therapeutic agents.
Seismic behavior of reduced beam section joints considering concrete floor effect
Authors: Lu Shengcan , Luo Liang , Han Xiangxi , Liu Anqi 
Published: February 2024

SummaryThis study investigates the seismic impact of concrete floors on reduced beam section beam‐to‐column joints through four quasi‐static cyclic tests. We examine mechanical properties, failure modes, and processes against specific criteria. Additionally, we analyze hysteretic response, energy dissipation, stiffness, capacity, and stress–strain mechanisms. Moreover, the ABAQUS platform was used to reproduce the specimen nonlinear finite element model to compare and analyze the test results. The results showed that the specimens exhibit excellent energy dissipation capacity and ductility (with a coefficient of 5.00); the column‐bar connection characteristics affect the maximum capacity and plastic hinge behavior in the reduced beam area. The reduced section of beam's upper flange could not improve the overall seismic performance of the joint. The observed failure sequence is as follows: concrete floor cracking, beam flange yielding, reinforcement fracture, lower flange yielding in the reduced beam area, and overall joint failure. This sequence confirms that the joint fulfills the design criteria of a “strong column‐weak beam” by achieving the target of plastic hinge outward movement.
Gold Fluorescence Nanoparticles for Enhanced SERS Detection in Biomedical Sensor Applications: Current Trends and Future Directions
Authors: Kalashgrani Masoomeh Yari , Mousavi Seyyed Mojtaba , Akmal Muhammad Hussnain , Gholami Ahmad , Omidifar Navid , Chiang Wei‐Hung , Althomali Raed H. , Lai Chin Wei , Rahman Mohammed M. 
Published: February 2024

AbstractNanotechnology has emerged as a pivotal tool in biomedical research, particularly in developing advanced sensing platforms for disease diagnosis and therapeutic monitoring. Since gold nanoparticles are biocompatible and have special optical characteristics, they are excellent choices for surface‐enhanced Raman scattering (SERS) sensing devices. Integrating fluorescence characteristics further enhances their utility in real‐time imaging and tracking within biological systems. The synergistic combination of SERS and fluorescence enables sensitive and selective detection of biomolecules at trace levels, providing a versatile platform for early cancer diagnosis and drug monitoring. In cancer detection, AuNPs facilitate the specific targeting of cancer biomarkers, allowing for early‐stage diagnosis and personalized treatment strategies. The enhanced sensitivity of SERS, coupled with the tunable fluorescence properties of AuNPs, offers a powerful tool for the identification of cancer cells and their microenvironment. This dual‐mode detection not only improves diagnostic accuracy but also enables the monitoring of treatment response and disease progression. In drug detection, integrating AuNPs with SERS provides a robust platform for identifying and quantifying pharmaceutical compounds. The unique spectral fingerprints obtained through SERS enable the discrimination of drug molecules even in complex biological matrices. Furthermore, the fluorescence property of AuNPs makes it easier to track medication distribution in real‐time, maximizing therapeutic effectiveness and reducing adverse effects. Furthermore, the review explores the role of gold fluorescence nanoparticles in photodynamic therapy (PDT). By using the complementary effects of targeted drug release and light‐induced cytotoxicity, SERS‐guided drug delivery and photodynamic therapy (PDT) can increase the effectiveness of treatment against cancer cells. In conclusion, the utilization of gold fluorescence nanoparticles in conjunction with SERS holds tremendous potential for revolutionizing cancer detection, drug analysis, and photodynamic therapy. The dual‐mode capabilities of these nanomaterials provide a multifaceted approach to address the challenges in early diagnosis, treatment monitoring, and personalized medicine, thereby advancing the landscape of biomedical applications.
Technological barriers to creating regional resilience in digital platform‐based firms: Compound of performance sensitivity analysis and BIRCH algorithm
Authors: Salamzadeh Aidin , Dana Leo‐Paul , Ebrahimi Pejman , Hadizadeh Morteza , Mortazavi Samira 
Published: February 2024

AbstractEntrepreneurial ventures face various problems contributing to the regional resilience of their districts. Among such firms are digital platform‐based businesses that could have exponential impacts—indeed, if they succeed in overcoming the barriers. Thus, this study aims to identify the major technological barriers to creating regional resilience in Iran's innovation districts. This study uses the analytical hierarchy process method and an unsupervised machine learning algorithm, as well as the Delphi technique. Online panel surveys are conducted to collect data from experts in the field of online social platforms. The findings show that digital literacy barriers and cultural barriers are the criteria with the uppermost and lowermost importance. Performance sensitivity analysis illustrates that considering the C1 and C4 criteria, the Digikala platform is more resistant to technological barriers compared to other platforms. Furthermore, based on C2 and C3 criteria, it can be stated that the Snapp platform reveals better resistance than the other platforms. The importance‐performance matrix also shows that all platforms need more attention in terms of performance. Besides, the results of the BIRCH analysis show that the present model's accuracy is 88%. Meanwhile, outputs show that experts are divided into four groups or four different thoughts.
LINC01572 promotes triple‐negative breast cancer progression through EIF4A3‐mediated β‐catenin mRNA nuclear exportation
Authors: Zheng Bowen , Zhou Baian , Ye Danrong , Wang Yuying , Zheng Wenfang , Wang Xuehui , Liu Diya , Qian Fengyuan , Zhou Xiqian , Yan Tao , Li Yating , Fang Lin 
Published: February 2024

AbstractLong noncoding RNAs have been reported to be involved in the development of breast cancer. LINC01572 was previously reported to promote the development of various tumors. However, the potential biological function of LINC01572 in breast cancer remains largely unknown. R language was used to perform bioinformatic analysis of The Cancer Genome Atlas data. The expression level of RNAs was examined by RT‐qPCR. The effect of knocking down or overexpression LINC01572 in triple‐negative breast cancer (TNBC) cell lines was evaluated by detecting cell proliferation, migrant action. RNA immunoprecipitation assay and RNA pull‐down assay were performed to explore the regulatory relationship between LINC01572, EIF4A3, and β‐catenin. Bioinformatics analysis identifies LINC01572 as an oncogene of breast cancer. LINC01572 is over‐expressed in TNBC tissues and cell lines, correlated with poor clinical prognosis in BC patients. Cell function studies confirmed that LINC01572 facilitated the proliferation and migration of TNBC cells in both vivo and vitro. Mechanistically, β‐catenin mRNA and EIF4A3 combine spatially to form a complex, LINC01572 helps transport this complex from the nucleus to the cytoplasm, thereby facilitating the translation of β‐catenin. Our findings confirm that LINC01572 acts as a tumor promoter and may act as a biomarker in TNBC. In addition, novel molecular regulatory relationships involving LINC01572/EIF4A3/β‐catenin are critical to the development of TNBC, which led to a new understanding of the mechanisms of TNBC progression and shows a new target for precision treatment for TNBC.
Students as Partners: Using an Equity‐Oriented Critical Assessment Practices (CAPS) Approach in Reading to Empower Students and Inform Instruction
Authors: Forzani Elena E. , Dobbs Christina , Leider Christine , Malik Emily , Gragg Melanie , Greszczuk Clara , Jesberger Courtney 
Published: February 2024

AbstractThis article offers a framework for more equitable classroom reading assessment known as a Critical Assessment Practices (CAPS) approach. CAPS includes a set of four principles that teachers can use to partner with, and to empower, students to support more equitable and informative classroom‐based reading assessment. Teachers can apply the CAPS approach to examine and adjust existing classroom reading assessment to make it more equitable and productive for students. The authors first describe a CAPS approach, then outline five stages teachers can use as they partner with students throughout assessment. Finally, the authors offer an example of how one first grade teacher applied a CAPS approach to adjust her existing assessment.
Identification of solar halo terms in observations recorded in historical Korean documents
Authors: Hyun Jae Yeon , Mihn Byeong‐Hee , Lee Ki‐Won , Kim Sang Hyuk , Bahk Uhn Mee 
Published: February 2024

AbstractWe investigate solar halo terms in observations recorded in the Crown Prince Sohyeon’s Donggung‐Ilgi (Seventeenth century) and identify their equivalent terminologies in modern atmospheric optics. We refer to related historical Korean and Chinese materials (e.g. Pungun‐Gi, Observation Log for Wind and Clouds, for 6 December 1748), analyse the distributions of each term according to the sun elevation and consult modern studies on halo simulations. Then, we compare our findings with the results of previous works. This study will contribute to the understanding of halo events recorded in historical East Asian documents.
Das Unterrichtsprojekt
Authors: Barton Daniel 
Published: February 2024

ZusammenfassungIn diesem Kapitel wird das Unterrichtsvorhaben, welches in dieser Studie untersucht wird, vorgestellt. Das geplante Lernarrangement wird in Form eines Projekts im Fach Mathematik in der 9. Jahrgangsstufe am Gymnasium umgesetzt und beinhaltet den übergeordneten Arbeitsauftrag der Produktion eines Erklärvideos in Gruppen zum Thema Raumgeometrie bzw. geometrische Körper der Sekundarstufe I.