bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análise espaço-temporal dos problemas decorrentes da restrição da vazão no baixo curso do Rio São Francisco
Authors: Santos Wagner Valdir dos , Nascimento Melchior Carlos 
Published: January 2024

O presente estudo tem como finalidade principal analisar os impactos decorrentes da restrição da vazão e seus efeitos sobre a dinâmica fluvial do baixo curso do rio São Francisco, especificamente no trecho correspondente ao município de Traipu – AL. Neste sentido, o trabalho buscou identificar a evolução e a gênese de barras fluviais emersas no período de 2013 a 2019. Para tanto, utilizou-se imagens distintas do satélite Landsat 8 e os dados da vazão disponíveis no Portal HidroWeb, do Sistema Nacional de Informações sobre Recursos Hídricos (SNIRH). Assim sendo, as análises por meio de imagens orbitais indicaram um aumento da área superficial das barras já existente e o surgimento de novas feições, quando comparado com as imagens relativas ao ano 2013. Considerando o comportamento da vazão defluente do reservatório, que correspondia em 2019 a 826 m3/s, no intervalo de aproximadamente seis anos, entre o período de 2013 a 2019, a área superficial das barras emersas aumentou 62,86%, ou seja, tiveram um acréscimo de 2,200 Km² passando a ocupar uma extensão de 5,700 Km². De maneira geral, os resultados mostraram que a utilização do geoprocessamento orientado à análise da paisagem foi eficaz para alcançar os objetivos propostos. A partir da análise das imagens de satélite, verificou-se que no período observado as dinâmicas de gênese e evolução das barras às margens do município de Traipú – AL possuem relação direta com a variação da vazão.
Oral cavity cancer incidence and survival trends: A population-based study
Authors: Gangane Nitin M. , Ghongade Pravinkumar V. , Patil Bharat U. , Atram Manisha 
Published: January 2024

ABSTRACT

Introduction:
The present study aimed to calculate the burden of oral cavity cancer (OCC) including incidence, mortality rate, survival rate, and influence of predictive factors such as clinicopathological, demographic findings, and treatment modalities.

Materials and Methods:
Data in this retrospective study were collected from India’s population-based cancer registry (PBCR) from 2010 to 2016. A total of 1051 cases of OCC were noted. Incidence and mortality rates were calculated. The cumulative survival outcome was calculated using Kaplan–Meier (KM) method. Prognostic factors were estimated using the Cox proportional hazard regression model.

Results:
The age-standardized incidence rates (ASR), and mortality rate (ASMR), of overall OCC cases were 10.1 and 8.4 per 100 thousand population, respectively. Five-year overall survival (OS) was 32.3%. Survival outcome was significantly associated with the given treatment (Chi-square value = 58.17, P = 0.0001) and anatomical site (Chi-square value = 26.70, P = 0.0001). 17.6% of cases in males were <39-year age group. The hazard ratio (HR) in the age group of >50 years was 2.065 (95% CI 1.34-3.18, P = 0.001). Combination therapy had an HR of 2.630 (95% CI 1.91-3.63, P value 0.000). Tonsillar carcinoma (C09) (95% CI 1.04-3.12) had 1.8 times more chances of death than lip carcinoma (C00).

Conclusion:
OCC cases are increasing in the younger population, and overall, cases show higher mortality rates with reduced survival outcomes. Prognostic factors such as age >50 years, single modality treatment, and alveolar and tonsillar malignancy are associated with poor survival. OCC robust screening by a trained health professional can improve early detection and increases awareness and lower mortality of the disease.
Metabolic puzzle: Exploring liver fibrosis differences in Asian metabolic-associated fatty liver disease subtypes
Authors: Shaikh Sabhita Shabir , Qazi-Arisar Fakhar Ali , Nafay Saba , Zaheer Sidra , Shaikh Hafeezullah , Azam Zahid 
Published: January 2024

BACKGROUND
Metabolic-associated fatty liver disease (MAFLD) is a liver condition marked by excessive fat buildup in the absence of heavy alcohol use. It is primarily linked with metabolic issues like insulin resistance, obesity, and abnormal lipid levels, and is often observed with other conditions such as type 2 diabetes and cardiovascular disease. However, whether the subtypes of MAFLD based on the metabolic disorder differentially impact liver fibrosis is not well explicated, especially in the Asian population.
AIM
To compare the severity of liver fibrosis among different MAFLD subtypes.
METHODS
A total of 322 adult patients of either gender with fatty liver on ultrasound were enrolled between January to December 2021. MAFLD was defined as per the Asian Pacific Association for the Study of the Liver guidelines. Fibrosis-4 index (Fib-4) and nonalcoholic fatty liver disease fibrosis score (NFS) were employed to evaluate liver fibrosis.
RESULTS
The mean age was 44.84 ± 11 years. Seventy-two percent of the patients were female. Two hundred and seventy-three patients were classified as having MAFLD, of which 110 (40.3%) carried a single, 129 (47.3%) had two, and 34 (12.5%) had all three metabolic conditions. The cumulative number of metabolic conditions was related to elevated body mass index, triglyceride (TG) levels, and glycated hemoglobin, lower high-density lipoprotein (HDL) levels, higher liver inflammation (by aspartate aminotransferase and γ-glutamyl transferase), and higher likelihood of fibrosis (by NFS and Fib-4 scores) (P < 0.05 for all). The proportion of advanced fibrosis also increased with an increase in the number of metabolic conditions (4.1%, 25.5%, 35.6%, and 44.1% by NFS and 6.1%, 10.9%, 17%, and 26.5% by Fib-4 for no MAFLD and MAFLD with 1, 2, and 3 conditions, respectively). Among MAFLD patients, those with diabetes alone were the eldest and had the highest mean value of NFS score and Fib-4 score (P < 0.05), while MAFLD patients diagnosed with lean metabolic dysfunction exhibited the highest levels of TG and alanine aminotransferase but the lowest HDL levels (P < 0.05) .
CONCLUSION
The study suggests that the severity of liver fibrosis in MAFLD patients is influenced by the number and type of metabolic conditions present. Early identification and management of MAFLD, particularly in patients with multiple metabolic conditions, are crucial to prevent liver-related complications.
Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease
Authors: Michalczuk Matheus Truccolo , Longo Larisse , Keingeski Melina Belén , Basso Bruno de Souza , Guerreiro Gabriel Tayguara Silveira , Ferrari Jessica T , Vargas José Eduardo , Oliveira Cláudia P , Uribe-Cruz Carolina , Cerski Carlos Thadeu Schmidt , Filippi-Chiela Eduardo , Álvares-da-Silva Mário Reis 
Published: January 2024

BACKGROUND
Prevalence of hepatocellular carcinoma (HCC) is increasing, especially in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
AIM
To investigate rifaximin (RIF) effects on epigenetic/autophagy markers in animals.
METHODS
Adult Sprague-Dawley rats were randomly assigned (n = 8, each) and treated from 5-16 wk: Control [standard diet, water plus gavage with vehicle (Veh)], HCC [high-fat choline deficient diet (HFCD), diethylnitrosamine (DEN) in drinking water and Veh gavage], and RIF [HFCD, DEN and RIF (50 mg/kg/d) gavage]. Gene expression of epigenetic/autophagy markers and circulating miRNAs were obtained.
RESULTS
All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis, and cirrhosis, but three RIF-group did not develop HCC. Comparing animals who developed HCC with those who did not, miR-122, miR-34a, tubulin alpha-1c (Tuba-1c) , metalloproteinases- 2 (Mmp2) , and metalloproteinases- 9 (Mmp9) were significantly higher in the HCC-group. The opposite occurred with Becn1 , coactivator associated arginine methyltransferase-1 (Carm1 ), enhancer of zeste homolog-2 (Ezh2 ) , autophagy-related factor LC3A/B (Map1 Lc3b) , and p62/ sequestosome-1 (p62/ SQSTM1)- protein. Comparing with controls, Map1 Lc3b , Becn1 and Ezh2 were lower in HCC and RIF-groups (P < 0.05). Carm1 was lower in HCC compared to RIF (P < 0.05). Hepatic expression of Mmp9 was higher in HCC in relation to the control; the opposite was observed for p62/Sqstm1 (P < 0.05). Expression of p62/SQSTM1 protein was lower in the RIF-group compared to the control (P = 0.024). There was no difference among groups for Tuba-1c , Aldolase-B, alpha-fetoprotein, and Mmp2 (P > 0.05). miR-122 was higher in HCC, and miR-34a in RIF compared to controls (P < 0.05). miR-26b was lower in HCC compared to RIF, and the inverse was observed for miR-224 (P < 0.05). There was no difference among groups regarding miR-33a, miR-143, miR-155, miR-375 and miR-21 (P > 0.05).
CONCLUSION
RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis through epigenetic modulation in a rat model of MASLD-HCC.
Preferences and Demand for Mosquito Control among Dengue-Endemic Communities in Peñuelas, Puerto Rico: An Application of the Best-Worst Choice Model
Authors: Madera-Garcia Valerie , Soto José R. , Ellingson Katherine D. , Jacobs Elizabeth , Walker Kathleen R. , Ernst Kacey C. 
Published: January 2024

ABSTRACT.
Aedes aegypti is the primary vector of dengue virus and threatens 3.9 billion people living in many tropical and subtropical countries. Prevention and reduction of dengue and other Aedes-borne viruses, including Zika and chikungunya, requires control of mosquito populations. Community mobilization and input are essential components of vector control efforts. Many vector control campaigns do not engage communities prior to implementation, leading to program failure. Those that do often conduct basic knowledge, attitude, and practice surveys that are not designed to explicitly elicit preferences. Here, we applied a novel stated preference elicitation tool, best-worst choice, to understand preferences, willingness to participate, and willingness to pay for mosquito control in dengue-endemic communities of Peñuelas, Puerto Rico. Findings revealed that the community preferred mosquito control programs that are 1) applied at the neighborhood level, 2) implemented by the local government, and 3) focused specifically on reducing disease transmission (e.g., dengue) instead of mosquito nuisance. Programs targeting the reduction of disease transmission and higher educational level of participants increased willingness to participate. Participants were willing to pay an average of $72 annually to have a program targeting the reduction of diseases such as dengue. This study serves as a model to engage communities in the design of mosquito control programs and improve stakeholders’ decision-making.
Seçilmiş Örnekler Bağlamında Osmanlı Minyatürlerde Yabancı Etkisi
Authors: Aslan Halide , Akter Farjana 
Published: January 2024

İslam minyatür sanatında Osmanlı minyatür sanat önemli bir yere sahiptir. Osmanlı Padişahların gözetiminde yaklaşık üç yüz yıl saray nakkaşhane Türk Minyatür sanatının en değerli eserleri ortaya koymuştur. Sanat seven Osmanlı padişahları nakkaşhanede hem yerli hem de yabancı sanatçılara sahib çıkmıştır. Dolayısıyla farklı stilde hakim olan sanatçıların ortak çabalarıyla Osmanlı minyatür sanatı Türk Minyatür sanatının aşırıi ilerleme çağı olmuştur. Ancak Osmanlı resminde yabancı etkisi olmasına rağmen, Osmanlı resminin mülkiyetini asla tutmadığını dikkat çekicidir. Fakat Osmanlı minyatürün bu kadar zenginliğini kazandığında tabi ki dışardan gelen ogelerin kuvvetli etkısı kanıtlanmıştır. Bu makalede Osmanlı minyatür sanatta etki eden yabancı özelliklerini tanımlamak açısından incelenmiştir. Araştırmada örneklem olarak kullanılan minyatürler dışında yer alan birçok yabancı etkisi taşıyan osmanalı minyatürleri de incelenip benzer ve farklı yönlerin tespit sağlanmıştır. Böylelikle oluşturulan verilerin ve sonuçların güçlendirilmesi sağlanmıştır.
PENGARUH DESKRIPSI PEKERJAAN DAN PENGALAMAN KERJA TERHADAP KINERJA KARYAWAN PADA PT. PLN (PERSERO) ULP HELVETIA MEDAN
Authors: Perdana Ari Irsyad , Rangkuti Sahnan , Al Firah Al Firah 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh deskripsi pekerjaan terhadap kinerja karyawan, untuk mengetahui pengaruh pengalaman kerja terhadap kinerja karyawan, untuk mengetahui pengaruh deskripsi pekerjaan dan pengalaman kerja terhadap kinerja karyawan Pada PT.PLN (Persero) ULP Helvetia Medan. Penelitian ini menggunakan sampel 99 karyawan. Penentuan sampel dilakukan dengan menggunakan teknik sampling jenuh. Pengumpulan data melalui kuesioner dan analisis data dilakukan dengan menggunakan uji regresi berganda. Hasil penelitian menunjukkan bahwa deskripsi pekerjaan secara parsial berpengaruh positif dan signifikanterhadap kinerja karyawan PT. PLN (Persero) ULP Helvetia Medan pada Tahun 2022 dengan nilai thitung sebesar 8,520 > ttabel sebesar 1,660. Karyawan sangat kesulitan dalam memahami deskripsi pekerjaan yang ditetapkan oleh perusahaan dan belum dievaluasi, sehingga kinerja karyawan menjadi tidak efektif dan efisien. Pengalaman kerja secara parsial berpengaruh terhadap kinerja karyawan PT. PLN(Persero) ULP Helvetia Medan pada Tahun 2022 dengan nilai thitung sebesar 5,437 > ttabel sebesar 1,660. Pengalaman kerja karyawan belum menjadi prioritas dalam perekrutan karyawan. Deskripsi pekerjaan dan pengalaman kerja secara simultan berpengaruh positif dan signifikan terhadap kinerja karyawan PT. PLN (Persero) ULP Helvetia Medan dengan nilai Fhitung sebesar 92,018 > Ftabel sebesar 2,70.Berdasarkan hasil uji koefisien determinasi diketahui bahwa variable deskripsi pekerjaan dan pegalaman kerja dapat menjelaskan tingkat kinerja karyawan sebesar 65%. Sementara sisanya (35%) dapat dijelaskan oleh faktor lain yang tidak diteliti penelitian ini.
PENGARUH MATERIAL HANDLING DAN PENATAAN LAYOUT TERHADAP EFISIENSI PROSES PRODUKSI PADA PT. CHAROEN POKPHAND INDONESIA CABANG MEDAN
Authors: Muthia Cindy , Asnawi Muhammad , Al Firah Al Firah 
Published: January 2024

Beberapa identifikasi masalah dalam penelitian ini mencakup masih adanya bahan baku yang rusak akibat suhu penyimpanan yang tidak sesuai standar produksi (material handling), masih adanya penataan layout mesin pabrik yang belum mendukung kelancaran proses produksi yang menyebabkan proses produksi terhambat, dan penerapan material handlingbelum sepenuhnya mendukung dalam upaya meningkatkan efisiensi proses produksi. Penelitian ini bertujuan untuk mengetahuipengaruh material handling terhadap efisiensi proses produksi,untuk mengetahui pengaruh penataan layout berpengaruh terhadap efisiensi proses produksi, untuk mengetahui pengaruh material handling dan penataan layout berpengaruh secara simultan terhadap efisiensi proses produksi padaPT. Charoen Pokphand Indonesia Cabang Medan. Penelitianini menggunakan sampel 84 karyawan. Penelitian ini menggunakan metode Accidental Sampling, dimana Accidental Sampling dengan menggunakan rumus Slovin. Teknik pengumpulan data menggunakan wawancara, observasi, kuesioner (angket) dengan analisis uji regresi berganda. Hasil penelitian menunjukkan bahwa variabel material handling secara parsial berpengaruh signifikan dengan variabel efisiensi proses produksi dengan nilai thitung> ttabel sebesar 3,415 >1,66365.Variabel penataan layout secara parsial berpengaruh signifikan dengan variabel efisiensi proses produksi dengan nilai thitung> ttabel sebesar13,787 > 1,66365. Variabel material handling dan penataan layout secara simultan berpengaruh signifikan dengan variabel efisiensi proses produksi dengan nilai Fhitung> Ftabel = sebesar 124.592 > 3,11.
Autism spectrum disorder – the fight of the public against a disease it fails to understand
Authors: Ahmed Minahel , Sikandar Eman , Javid Arysha 
Published: January 2024

Madam,
Autism is a heterogeneous set of neurodevelopmental conditions affecting around 1% of the population globally [1,2] and every 1 in 120 people in Pakistan [5]. It exhibits a higher incidence in males than females [1,2,5]; this may be because males have a lower threshold for brain dysfunction, and require a lower genetic burden to cause autism, than females. Individuals with autism commonly experience impaired social cognition and perception, atypical information processing, and restricted patterns of behaviour and interest. A study from The Lancet in 2014 determined that the autism goes hand in hand with multiple other intellectual, psychiatric, medical, and behavioural disorders, with a significant association between autism and motor abnormality, sleep disorders, and aggressive behaviours [1]. While multiple genetic and developmentally early environmental factors have been established as risk factors in the aetiology of autism, none were confirmed to be adequate alone for ASD to develop.
With respect to familiarity with autism, while people are not completely unaware of the existence of the disease they do display poor knowledge about its symptoms and presentation. In a study conducted in Pakistan in 2012, 52 out of the 73 teachers who participated (71%) claimed to have knowledge regarding autism; substantial gaps were recognized in their perceived knowledge about the disease [3]. Another study conducted in Karachi also concluded that parents’ lack of awareness and insufficient knowledge among parents about the signs and symptoms as well as the treatment and diagnosis of autism [4].
Early diagnosis is crucial for timely intervention; the assessment of children needs to be developmental and multidisciplinary [1]. Even though multiple rating scales and checklists have been established, it is preferable to use more performance-based methodologies for assessment and diagnosis [2]. Thorough and focused behavioral interventions in early life can promote social communication and decrease aggression and anxiety in individuals diagnosed with ASD. Support should be personalized according to each individual and if feasible, should be multi-dimensional. Although drugs as a form of treatment diminish comorbid symptoms in autistic people, they alone display no direct effect on enhancing social communication. Awareness can be spread by donating or volunteering at fundraisers, through social media, and by participating in various autism programs. Formation of an encouraging environment that acknowledges and respects that the individual is different is imperative.
EFEKTIVITAS PEMBERIAN EKSTRAK TEMULAWAK MADU DENGAN PENURUNAN NYERI HAID PADA REMAJA PUTRI
Authors: Juliani Sri , Nasution Ramadhani Syafitri , Harahap Novi Ramini , Rambe Nur Insan 
Published: January 2024

Latar Belakang: Nyeri haid dikenal dengan nyeri pada perut selama menstruasi diakibatkan adanya peningkatan uterus berupa gangguan nyeri dan kram pada perut sehingga mengakibatkan ketidak nyamanan serta bisa menganggu aktifitas sehari-hari. Menurut (WHO) tahun 2015 angka kejadian dismenore sangat tinggi. Diperkirakan 50% wanita didunia mengalami nyeri haid. Angka kejadian dismenore di Indonesia terdiri dari 54,89% dismenore primer dan 9,36% dismenore skunder. Tujuan: Tujuan penelitian ini adalah untuk mengetahui Efektivitas Pemberian Ekstrak Temulawak Madu Dalam Penurunan Nyeri Haid Pada Remaja Putri Di SMK Negeri 13 Medan Tahun 2022. Metode : Jenis penelitian ini menggunakan pre-eksperimental design dengan pendekatan the one group pretest posttest design. Populasi dalam penelitian ini adalah seluruh siswi kelas XI PBD (Pemasaran Bisnis Dan Daring) yang mengalami nyeri haid saat menstruasi. Sampel sebanyak 15 responden menggunakan teknik Purposive Sampling dengan analisa univariat. Hasil: Hasil penelitian menunjukkan pada pretest terdapat nilai mean 2,4667 nilai minimum 1,00 dan maksimum 4,00 dan posttest nilai mean menjadi 1,1333 minimum 0,0 dan maksimum 3,00. Berdasarkan uji statistic dengan menggunakan uji Wilcoxon dengan nilai p=0,000<0,050, maka dapat disimpulkan bahwa terdapat pengaruh pada pemberian ekstrak temulawak madu dalam penurunan nyeri haid pada remaja putri di smk negeri 13 medan tahun 2022. Kesimpulan: Kesimpulan dari penelitian ini adalah terdapat pengaruh yang signifikan antara pemberian ekstrak temulawak madu dalam penurunan nyeri haid pada remaja putri. Diharapkan kepada remaja putri untuk mengkonsumsi jamu temulawak madu dalam penurunan nyeri haid.
Peningkatan Prestasi Belajar dan Motivasi Siswa XII IPA 1 MAN Buleleng melalui Penerapan Model Pembelajaran Berbasis Proyek PLTB (Pembangkit Listrik Tenaga Buah)
Authors: Rohmaya Nikmatur 
Published: January 2024

Penelitian bertujuan untuk mengetahui peningkatan prestasi belajar dan motivasi siswa XII IPA 1 MAN Buleleng melalui penerapan model pembelajaran berbasis proyek PLTB (pembangkit listrik tenaga buah). Penelitian ini merupakan penelitian tindakan kelas (PTK) yang dilaksanakan dalam dua siklus, setiap siklus terdiri dari empat tahapan kegiatan yakni perencanaan, pelaksanaan tindakan, pengamatan, dan refleksi. Subjek penelitian ini adalah siswa kelas XII IPA 1 MAN Buleleng yang berjumlah 33 siswa pada semester ganjil tahun pelajaran 2022/2023. Penelitian ini melibatkan satu orang observer. Teknik pengumpulan data yang digunakan yaitu teknik tes, observasi, dan angket motivasi belajar siswa yang dianalisis menggunakan teknik analisis deskriptif. Hasil penelitian menunjukkan bahwa (1) Model pembelajaran berbasis proyek PLTB dapat meningkatkan prestasi belajar siswa. Nilai rata-rata siswa saat pretest sebesar 55,03 mengalami peningkatan menjadi 68,56 pada siklus 1 dan 75,00 pada siklus 2. presesntase ketuntasan siswa saat pretest sebesar 16,13% meningkat menjadi 58,06% pada siklus 1 dan 77,42% pada siklus 2. Indikator keberhasilan penelitian tindakan kelas telah tercapai pada siklus 2. (2) Siswa memberikan respon yang positif terhadap pembelajaran sel volta yang dilaksanakan dengan model pembelajaran berbasis proyek PLTB dengan rata-rata 73,33% sangat termotivasi dan 26,67% termotivasi.
Menakar Kesiapan Guru Madrasah Dalam Implementasi Kurikulum Merdeka
Authors: Andana Prawira Yudha , Nugraha Firman 
Published: January 2024

This research was carried out based on doubts from several parties about the success of the implementation of the independent curriculum rolled out by the government. Therefore, researchers went into the field to dig data from the spearhead of curriculum implementation, namely madrasah and teachers. The study was conducted by descriptive method. The instruments used are interviews and open questionnaires. The resulting findings that have been analyzed by descriptive studies show that from the aspect of teachers, both the age and length of service of teachers stated that they were ready to implement an independent curriculum. Meanwhile, from the madrasah aspect, both the ibtidiyah, tsanawiyah, and aliyah madrasah levels, also stated that they were ready to implement an independent curriculum, even for the aliyah madrasah level, all subjects wanted this curriculum change.