bluuebunny/crossref_metadata_2025_split huggingface dataset:
RCFS: Rate and Cost Fair CPU Scheduling Strategy in Edge Nodes
Authors: Zhao Yumiao , Rao HuanLe , Le Kelei , Wang Wei , Xu Youqing , Jia Gangyong 
Published: December 2023

Abstract

The cloud-edge collaborative edge computing paradigm is driving the comprehensive development of the Internet of Things. With the widespread deployment of 5G mobile networks, IoT end devices tend to offload data to more powerful edge nodes for computing, thereby improving the speed. This has led to an explosive growth in the amount of data processed by edge nodes. General CPU scheduling strategies are unsuitable for edge nodes that frequently occur in data-intensive applications. In this study, we focus on application feature awareness and design a strategy that considers data arrival rate and cost-fair CPU scheduling (RCFS) with two components: CPU resource allocation based on process weights and process scheduling based on distributed weighted round-robin. Compared to the Linux default scheduling strategy, CFS, experiments on edge nodes show that the RCFS strategy can effectively improve CPU utilization, decrease the running time of data-intensive applications, and improve the system’s data throughput. In the best-case scenario, the RCFS strategy enhanced CPU utilization by up to 98.5%, decreased running time by up to 45.5%, and increased data throughput by up to 58.7%.
Evaluation of different levels of Nutrient and Growth Regulators on seed protein, seed Test Weight and available Post-harvest Soil Nutrient Status in Pearl Millet (Pennisetum glaucum (L)
Authors: Guru G , Suresh Gurrala , M.Marimuthu  , Ravichandran V. , Lokanadhan Subbalakshmi 
Published: December 2023

Abstract
Field trial was conducted to evaluate the levels of nutrients and growth regulators on quality of seed protein content, grain weight, and soil fertility status in pearl millet in rabi season of 2019-21 at Department of Millets, Directorate of PB&G, TNAU, Coimbatore. The experiment was conducted for three years and ten treatments were tried with replicated thrice. Plant Growth regulator is a chemical substances that help for developing growth of plant, progress for high yield, get superior quality of grain. The treatment 125 % Recommended dose of fertilizer with chlormequat chloride at 250 ppm on 20 and 40 Days after sowing recorded maximum grain protein content, test weight and nutrients uptake during the crop growing period. Simultaneously 125 % Recommended dose of fertilizer with foliar applied chlormequat chloride @ 250 ppm on 20th and 40th days after sowing was indicated more available soil nutrient status after harvest of the crop which was on par with 125 % RDF + NAA @ 250 ppm at 20 and 40 Days after sowing and other Recommended fertilizer dose treatments. The treatments effects were influenced on protein content and test weight of pearl millet with nutrients and growth regulators. The response of pearl millet to applied nitrogen as well as PGRs can be attributed to the favourable effect on yield and yield-attributing characters. This should be due to the reason that nitrogen fertilizer leads to higher availability of nutrients to facilitate promotion of growth and development furthermore resulting in rising yield attributes and yield.
WITHDRAWN: EIF4A3-regulated circGNAI2 inhibits the progression of triple-negative breast cancer by circGNAI2-miR-454-3p-VGLL4 axis
Authors: song hongming , Wang Haibo , Peng Jing , Niu Zhaohe , Liu Xiangping , lv Meng , Mao Yan , Wang Yuanyuan , Wang Yongmei , Wang Xinggang , Liu Fang 
Published: December 2023

Abstract
Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer (BC) with high invasiveness, high rate of recurrence and metastasis, and poor prognosis. In this study, we demonstrated that circGNAI2 was lower expressed in TNBC tissues and cell lines. CircGNAI2 suppressed the proliferation and migration abilities of TNBC cells in vivo and in vitro. Of note, circGNAI2 can upregulate VGLL4 and inhibit the phosphorylation of STAT3 via sponging miR-454-3p. Moreover, circGNAI2 was downregulated by EIF4A3. Taken together, EIF4A3-regulated circGNAI2 could inhibit TNBC progression by regulating circGNAI2-miR-454-3p-VGLL4 axis and STAT3 signaling pathway, providing pivotal potential therapeutic targets for the treatment of TNBC.
Random forest and support vector machine classifiers for coastal wetland characterization using the combination of features derived from optical data and synthetic aperture radar dataset
Authors: Cherian Sandra Maria , K Rajitha 
Published: December 2023

Abstract

Mapping mangrove forests is crucial for their conservation, but it is challenging due to their complex characteristics. Many studies have explored machine learning techniques that use Synthetic Aperture Radar (SAR) and optical data to improve wetland classification. This research compares the random forest (RF) and support vector machine (SVM) algorithms, employing Sentinel-1 dual polarimetric C-band data and Sentinel-2 optical data for mapping mangrove forests. The study also incorporates various derived parameters. The Jeffries–Matusita distance and Spearman’s rank correlation are used to evaluate the significance of commonly used spectral indices and SAR parameters in wetland classification. Only significant parameters are retained, reducing data dimensionality from 63 initial features to 23–33 essential features, resulting in an 18% improvement in classification accuracy. The combination of SAR and optical data yields a substantial 33% increase in the overall accuracy for both SVM and RF classification. Consistently, the fusion of SAR and optical data produces higher classification accuracy in both RF and SVM algorithms. This research provides an effective approach for monitoring changes in Pichavaram wetlands and offers a valuable framework for future wetland monitoring, supporting the planning and sustainable management of this critical area.
Comparison of multi-source satellite remote sensing observations for monitoring the variations of small lakes: a case study of Dai Lai Lake (Vietnam)
Authors: Pham-Duc Binh 
Published: December 2023

Abstract

This study compares the capability of Sentinel-1, Sentinel-2, and PlanetScope (PS) satellites in monitoring the variations of surface water of Dai Lai Lake, located in North Vietnam, for the 2018–2023 period. The analysis involves the utilization of Google Earth Engine to partially process Sentinel-1 and Sentinel-2 observations, while PS observations are processed using local computers, to generate VH-polarized backscatter coefficient, Normalized Difference Water Index (NDWI), and Modified of Normalized Difference Water Index (MNDWI) maps. The method for making binary water/non-water maps primarily employs the Otsu algorithm on each single map derived from the previous step. Findings reveal that the lake's water extent remains relatively stable over the 6-year period, and is not strongly affected by the seasonal cycle. Although the spatial distribution patterns of the lake exhibit significant similarity, average water extent of the lake derived from 3-m resolution PS imagery is about 2.17 and 5.60% more than that obtained from 10-m resolution Sentinel-2 and Sentinel-1 imagery, respectively. PS observations are effective for monitoring small lakes, but it is advised to check the quality of its NIR band. Sentinel-2 observations prove great effectiveness for lake monitoring, using both NDWI and MNDWI. For Sentinel-1 observations, potential misclassifications could arise due to similarities in VH-polarized backscatter coefficients between water surfaces and other flat surfaces.
QTc Prolongation to Predict Mortality in Patients Admitted with
COVID-19 Infection: An Observational Study
Authors: Sartorio Andrea , Burrei Giulia , Cristin Luca , Zoncapè Mirko , Carlin Michele , Tadiello Enrico , Minuz Pietro , Dalbeni Andrea , Romano Simone 
Published: December 2023

Background:
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes
Coronavirus disease 2019 (COVID-19), characterized by pulmonary infection ranging from asymptomatic
forms to respiratory insufficiency and death. Evidence of cardiac involvement in COVID-19
is increasing, and systemic inflammation or direct heart damage by SARS-CoV-2 can prolong the
corrected QT interval (QTc).

Methods:
In this observational study, a total of 333 consecutive patients admitted to the Covid Center
of Verona University Hospital from November 2020 to April 2021 were included. Patients with bundle
branch block, pacemaker-controlled heart rhythm and heart rate >120 beats/min were excluded. A
complete electrocardiogram (ECG) was performed at admission, and QTc values of ≥440 ms for
males and ≥460 ms for females were considered prolonged.

Results:
Overall, 153 patients had prolonged QTc (45.5%). In multivariate logistic regression analysis,
male sex (odds ratio (OR)=6.612, p=0.046), troponin (OR=1.04, p=0.015) and lymphocyte count
(OR=3.047, p=0.019) were independently associated with QTc prolongation. Multivariate logistic
regression showed that QTc was independently associated with mortality (OR=4.598, p=0.036). Age,
sex, the ratio between the partial pressure of oxygen (PaO2) and the fraction of inspired oxygen
(FiO2) (P/F), and fibrosis-4 index for liver fibrosis (FIB-4) were also independently associated with
mortality.

Conclusion:
QTc interval prolongation appears to be a frequent finding in patients with COVID-19.
Moreover, prolonged QTc may be predictive of more severe forms of COVID-19 and worse outcome.
Effects of Kojic Acid-mediated Sonodynamic Therapy as a Matrix
Metalloprotease-9 Inhibitor against Oral Squamous Cell Carcinoma: A
Bioinformatics Screening and In Vitro Analysis
Authors: Pourhajibagher Maryam , Alaeddini Mojgan , Etemad-Moghadam Shahroo , Parker Steven , Bahador Abbas 
Published: December 2023

Background:
Oral squamous cell carcinoma (OSCC) is a type of cancer that is responsible
for a significant amount of morbidity and mortality worldwide. Researchers are searching for promising therapeutic methods to manage this cancer. In this study, an in silico approach was used to
evaluate the activity of sonodynamic therapy (SDT) based on the use of Kojic acid as a sonosensitizer
to inhibit matrix metalloprotease-9 (MMP-9) in OSCC.

Materials and Methods:
The three-dimensional structure of MMP-9 was predicted and validated by
computational approaches. The possible functional role of MMP-9 was determined in terms of Gene
Ontology (GO) enrichment analysis. In silico, molecular docking was then performed to evaluate the
binding energies of Kojic acid with MMP-9, and ADME parameters and toxicity risks were predicted.
The pharmacokinetics and drug-likeness properties of Kojic acid were assessed. Moreover, after the
determination of the cytotoxicity effect of Kojic acid-mediated SDT, the change of mmp-9 gene expression was assessed on OSCC cells.

Results:
The results of the study showed that Kojic acid could efficiently interact with MMP-9 protein with a strong binding affinity. Kojic acid obeyed Lipinski’s rule of five without violation and
exhibited drug-likeness. The cytotoxic effects of Kojic acid and ultrasound waves on the OSCC cells
were dose-dependent, and the lowest expression level of the mmp-9 gene was observed in SDT.

Conclusions:
Overall, Kojic acid-mediated SDT as an MMP-9 inhibitor can be a promising adjuvant
treatment for OSCC. The study highlights the potential of in silico approaches to evaluate therapeutic
methods for cancer treatment.
Some Versatile Medicinal Plants for Healing Wounds: A Review
Authors: Kumari Raj , Sharma Meenakshi , Mittal Abhilasha , Goel Gauri 
Published: December 2023

Abstract:
The cellular and biochemical stages of the wound-healing process are interrelated and work to repair the wound. The body heals wounds in stages,
and each stage that is postponed raises the risk of microbial infection. The time needed for healing can be sped up, and unwanted events can be
reduced to improve wound healing. To aid in the healing of the wounds, the medications are administered locally or systemically. In order to
promote wound healing, antibiotics, antiseptics, desloughing agents, extracts, etc. have been employed. Due to their adverse effects, several
synthetic medications are subject to restrictions. Investigation, identification, and formulation of plants or plant-derived combinations are required
for the management and therapy of wound healing. Because they have fewer adverse effects and have been used to treat wounds for a longer
period, medicinal plants are becoming more popular for use in wound healing. According to studies, medicinal herbs help diabetic, infected, and
opened wounds heal more quickly. It has been claimed that medicinal herbs can speed up wound healing through a variety of processes. Many
medicinal plants, including Allium sativum, Commiphora myrrha, Curcuma longa (L.), Rauwolfia serpentia, and Vateria indica, have
demonstrated the ability to treat wounds.
Cost-effectiveness of Dementia Medication
Authors: Khera Nikita , Raj Rojin G. , Kumar Ranjeet , Bajaj Megha , Sharma Bintoo , Tyagi Harsh , Job Josmy Maria 
Published: December 2023

Aim::
This review has examined and organized the available research on dementia medication care costs. Although the accessible database in this area is
growing and is still quite limited, there are many clear scientific methods.

Objective::
The use of Memantine, a non-competitive antagonist with low to moderate affinity for the NMDA (N-methyl-D-aspartate) receptor, has been
approved for the treatment of mild to moderately severe Alzheimer's disease (AD). The efficacy of cholinesterase inhibitors (ChEIs) in the
treatment of dementia varies depending on the drug type and ease of administration. Numerous techniques have been employed to evaluate the
quality of life (QOL) of individuals suffering from dementia. QOL data is a well-established measure of an intervention's effectiveness. Up to now,
cost-effectiveness studies have concentrated on both pharmaceutical and non-pharmacological therapy. Each unit of QoL-AD improvement costs
USD27.82578 at mean values.

Methods::
Searches were conducted to observe studies of the pharmacoeconomic impact of dementia medications with the help of previous articles published
in journals and collected from Google Scholar with name search dementia or Alzheimer's cross-referenced with pharmacoeconomic or costs and
effectiveness.
Increasing Realism and Variety of Virtual Patient Dialogues for Prenatal Counseling Education Through a Novel Application of ChatGPT: Exploratory Observational Study
Authors: Gray Megan , Baird Austin , Sawyer Taylor , James Jasmine , DeBroux Thea , Bartlett Michelle , Krick Jeanne , Umoren Rachel 
Published: December 2023

Background
Using virtual patients, facilitated by natural language processing, provides a valuable educational experience for learners. Generating a large, varied sample of realistic and appropriate responses for virtual patients is challenging. Artificial intelligence (AI) programs can be a viable source for these responses, but their utility for this purpose has not been explored.

Objective
In this study, we explored the effectiveness of generative AI (ChatGPT) in developing realistic virtual standardized patient dialogues to teach prenatal counseling skills.

Methods
ChatGPT was prompted to generate a list of common areas of concern and questions that families expecting preterm delivery at 24 weeks gestation might ask during prenatal counseling. ChatGPT was then prompted to generate 2 role-plays with dialogues between a parent expecting a potential preterm delivery at 24 weeks and their counseling physician using each of the example questions. The prompt was repeated for 2 unique role-plays: one parent was characterized as anxious and the other as having low trust in the medical system. Role-play scripts were exported verbatim and independently reviewed by 2 neonatologists with experience in prenatal counseling, using a scale of 1-5 on realism, appropriateness, and utility for virtual standardized patient responses.

Results
ChatGPT generated 7 areas of concern, with 35 example questions used to generate role-plays. The 35 role-play transcripts generated 176 unique parent responses (median 5, IQR 4-6, per role-play) with 268 unique sentences. Expert review identified 117 (65%) of the 176 responses as indicating an emotion, either directly or indirectly. Approximately half (98/176, 56%) of the responses had 2 or more sentences, and half (88/176, 50%) included at least 1 question. More than half (104/176, 58%) of the responses from role-played parent characters described a feeling, such as being scared, worried, or concerned. The role-plays of parents with low trust in the medical system generated many unique sentences (n=50). Most of the sentences in the responses were found to be reasonably realistic (214/268, 80%), appropriate for variable prenatal counseling conversation paths (233/268, 87%), and usable without more than a minimal modification in a virtual patient program (169/268, 63%).

Conclusions
Generative AI programs, such as ChatGPT, may provide a viable source of training materials to expand virtual patient programs, with careful attention to the concerns and questions of patients and families. Given the potential for unrealistic or inappropriate statements and questions, an expert should review AI chat outputs before deploying them in an educational program.
Penatalaksanaan Anestesi pada Operasi Orif E.C Fraktur Ankle pada Pasien dengan Fraktur Servikal
Authors: Zaenal Arifin  , IG Ngurah Rai Artika  
Published: December 2023

Latar Belakang. Fraktur cervical kira-kira terjadi ada 5-10% pasien yang datang ke Instalasi Gawat Darurat dalam keadaan tidak sadar. Kebanyakan fraktur cervical tersebut terjadi pada 2 level. Sepertiga dari fraktur terjadi pada level C2 dan 2/3 lainnya terjadi pada level C6 atau C7.Kasus. Dilaporkan penatalaksanaan anestesi pada operasi ORIF terhadap seorang laki-laki umur 22 tahun dengan fraktur terbuka bimaleoler dari ankle kiri, dengan oedem cerebri dan fraktur cervical IV.
Anestesi dilakuan dengan teknik blok saraf perifer yaitu kombinasi blok nervus femoralis dan blok nervus sciatik distal. Pada blok nerfus femoralis digunakan obat anetesi local berupa lidocaine 1% 20 cc dan pada blok nervus sciatik distal diberikan obat anestesi local berupa bupivacaine 0,5% isobaric 25 cc.Operasi berlangsung selama 3 jam 20 menit. Durante operasi hemodinamik stabil. Tekanan darah sistolik berkisar 100-125 mmHg, diastolic 65-80 mmHg, frekuensi jantung 70-95 x/menit. Perdarahan sekitar 100 cc dan urine output 200 cc. Post operasi pasien kembali ke bangsal
EFEK PEMBERIAN PRIMING FENTANIL 1 ΜG/KGBB TERHADAP INSIDENSI BATUK PASCA-PREEMPTIF ANALGESIA FENTANIL 2ΜG/KGBB DI RSUP DR. SARDJITO
Authors: Prakosa Nur Hamam , Uyun Yusmein , Widyastuti Yunita 
Published: December 2023

Latar belakang: Fentanil merupakan analgetik opioid yang hampir selalu digunakan pada pasien yang menjalani anestesi umum. Penggunaan fentanil intravena bisa menimbulkan efek batuk yang dikenal dengan istilah fentanyl– induced cough (FIC). Hingga saat ini belum ditetapkan terapi standar dalam mencegah terjadinya FIC.
Metode: Uji klinis randomisasi dengan pembutaan ganda. Sampel dipilih menggunakan metode non-probability sampling dengan cara konsekutif sampai terpenuhi jumlah sampel. Pasien dengan rentang usia 18-65 tahun, status fisik ASA I-II, bukan perokok aktif, yang menjalani operasi elektif dengan pembiusan umum di RSUP Dr. Sardjito, dikelompokkan menjadi 2 kelompok yaitu kelompok perlakuan dengan penggunaan priming fentanil 1 μg/kgbb dan kelompok kontrol tanpa priming fentanil. Kedua kelompok perlakuan tersebut mendapatkan total fentanil 2 μg/kgbb dengan kecepatan penyuntikan 0,5 cc per detik. Dinilai perbedaan insidensi batuk diantara kedua kelompok perlakuan dengan luaran berupa batuk ringan, batuk berat, maupun tidak batuk maka dilakukan dengan uji Chi-square. Luaran sekunder dan efek samping terhadap pemberian fentanil juga dinilai.
Hasil: Insidensi batuk pada kelompok perlakuan dengan penggunaan priming fentanil 1 μg/kgbb sebanyak 2 pasien (2,7%) sedangkan insidensi batuk pada kelompok tanpa pemberian priming fentanil sebanyak 11 pasien (15,1%) dengan p = 0,009 artinya ada perbedaan bermakna secara statistika. Pasien dengan insidensi batuk seluruhnya dalam kategori batuk ringan baik kelompok priming fentanil sebanyak 2 pasien maupun kelompok tanpa priming fentanil 11 pasien.
Kesimpulan: Penggunaan priming fentanil 1 μg/kgbb dapat mengurangi insidensi batuk secara bermakna pascapreemptif analgesia fentanil 2 μg/kgbb dengan kecepatan penyuntikan 0,5 cc per detik. Penggunaan priming fentanil 1 μg/kgbb mempunyai insidensi efek samping yang tidak bermakna dibandingkan tanpa pemberian priming fentanil pascapreemptif analgesia fentanil 2 μg/kgbb dengan kecepatan penyuntikan 0,5 cc per detik.
PENANGANAN BARANG BUKTI BENIH BENING LOBSTER MELALUI MEKANISME PELEPASLIARAN SEBAGAI UPAYA MELESTARIKAN KOMODITAS LOBSTER
Authors: Herdiana Widia , Sulistiani Lies , Imamulhadi Imamulhadi 
Published: December 2023

ABSTRAK
Penyelundupan Benih Bening Lobster (BBL) merupakan permasalahan yang banyak disoroti sejak PERMEN KP Nomor 1 Tahun 2015 dibuat. Maraknya kasus menjadi masalah bagi ekosistem laut. Karenanya, berdasarkan PERMEN KP Nomor 17 Tahun 2021 mengatur mekanisme pelepasliaran barang bukti BBL. Pelepasliaran merupakan pelestarian spesies dengan cara mempertahankan keberadaan suatu spesies dengan menyerahkan perkembangan ke habitat aslinya. Proses pelepasliaran yang dilakukan penyidik perikanan merupakan salah satu cara untuk menegakkan hukum dalam melindungi ekosistem laut. Selain oleh penyidik, peran serta masyarakat untuk menjaga ekosistem laut juga penting. Metode penelitian: yuridis normatif yaitu menganalisis kenyataan dengan aturan hukum yang berlaku. Hasil disajikan dalam bentuk deskriptif untuk menggambarkan permasalahan yang ada yang kemudian dianalisis sehingga menghasilkan suatu kesimpulan. Kenyataan yang ada menunjukkan bahwa penegak hukum dalam proses penyidikan telah secara nyata menerapkan penanganan barang bukti BBL yang mengedepankan asas kelestarian. Tetapi aturan hukum terkait hal tersebut hanya ada pada tingkatan PERMEN bukan dalam tingkatan Undang-undang.
Kata kunci: Barang Bukt; BBL; Pelepasliaran.
ABSTRACT
Smuggling of Clear Lobster Seeds (BBL) is a problem that has been highlighted a lot since PERMEN KP Number 1 of 2015 was made. The rise of cases is a problem for the marine ecosystem. Therefore, based on PERMEN KP Number 17 of 2021 it regulates the mechanism for releasing BBL evidence. Release is the preservation of species by maintaining the existence of a species by surrendering its development to its natural habitat. The release process carried out by fisheries investigators is one way to enforce the law in protecting marine ecosystems. Apart from investigators, the role of the community in protecting marine ecosystems is also important. Research method: normative juridical, namely analyzing reality with the applicable legal rules. The results are presented in a descriptive form to describe the existing problems which are then analyzed to produce a conclusion. The existing facts show that law enforcers in the investigation process have actually implemented the handling of BBL evidence that prioritizes the principle of sustainability. However, legal regulations regarding this matter only exist at the PERMEN level, not at the Law level.
Keywords: BBL; Evidence; Release.