bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fuzzy multi-criteria decision-making framework for controlling methane explosions in coal mines
Authors: Kursunoglu Nilufer 
Published: January 2024

AbstractThe structure of underground coal mines is vulnerable to many mishaps because of the challenging conditions of production and the unique features of the earth. These incidents could cause significant financial and production losses for the mines in addition to worker injury, disability, or death. In coal mines, methane explosions are a frequent threat. Establishing a safe work environment requires managing these problems with an accident control method. The current study used the fuzzy TOPSIS and fuzzy AHP techniques for this aim. The framework was used to tackle the four-alternative problem of underground coal mine explosion control method selection. To identify potential risks of a methane explosion, a data gathering survey was conducted as part of the suggested hybrid methodology. The fuzzy AHP was used to compute the fuzzy weights of the hazards. “Improper ventilation system” is ranked highest out of the 34 sub-risk factors. The fuzzy TOPSIS was then utilized to rank the explosion control methods using the weights. To assess the viability of the study’s conclusions, a sensitivity analysis was carried out. The findings indicate that “improving safety technology” and “financial investments” are the best ways to reduce such events. The results additionally indicate that the fuzzy TOPSIS approach in combination with the fuzzy AHP provides a helpful framework for dynamically assessing mine methane explosion accidents.
Plasma SHBG Levels as an Early Predictor of Response to Bariatric Surgery
Authors: Gabriel-Medina P. , Ferrer-Costa R. , Rodriguez-Frias F. , Comas M. , Vilallonga R. , Ciudin A. , Selva D. M. 
Published: January 2024

Abstract
Background
Obesity is a growing global health problem, and currently, bariatric surgery (BS) is the best solution in terms of sustained total weight loss (TWL). However, a significant number of patients present weight regain (WR) in time. There is a lack of biomarkers predicting the response to BS and WR during the follow-up. Plasma SHBG levels, which are low in obesity, increase 1 month after BS but there is no data of plasma SHBG levels at long term. We performed the present study aimed at exploring the SHBG role in predicting TWL and WR after BS.

Methods
Prospective study including 62 patients with obesity undergoing BS. Anthropometric and biochemical variables, including SHBG were analyzed at baseline, 1, 6, 12, and 24 months; TWL ≥ 25% was considered as good BS response.

Results
Weight loss nadir was achieved at 12 months post-BS where maximum SHBG increase was reached. Greater than or equal to 25% TWL patients presented significantly higher SHBG increases at the first and sixth months of follow-up with respect to baseline (100% and 150% respectively, p = 0.025), than < 25% TWL patients (40% and 50% respectively, p = 0.03). Also, these presented 6.6% WR after 24 months. The first month SHBG increase predicted BS response at 24 months (OR = 2.71; 95%CI = [1.11–6.60]; p = 0.028) and TWL in the 12th month (r = 0.330, p = 0.012) and the WR in the 24th (r =  − 0.301, p = 0.028).

Conclusions
Our results showed for the first time that increase in plasma SHBG levels within the first month after BS is a good predictor of TWL and WR response after 2 years.

Graphical Abstract
Surgery combined with adjuvant radiation and chemotherapy prolonged overall survival in stage IVC anaplastic thyroid cancer: a SEER-based analysis
Authors: Yin Ying , Wang Linhe , Huang Chiming 
Published: January 2024

Abstract
Background
Anaplastic thyroid carcinoma (ATC) is a rare but aggressive malignancy, which accounts for only 1–2% of all thyroid cancers. The median overall survival (OS) time for all stages patients is at about 5 months. The benefit of surgery combined with adjuvant radiation and chemotherapy in stage IVC anaplastic thyroid cancer is still controversial. The aim of this study is to investigating surgery combined with adjuvant radiation and chemotherapy and survival outcomes in stage IVC ATC patients.

Method
Anaplastic thyroid carcinoma patients from the Surveillance, Epidemiology, and End Results database from 2004 to 2016 were used to conduct a cross-sectional study in the analysis. The endpoint of this study was overall survival.

Results
The median OS of the overall population was 2.0 months. Multivariate analysis showed that age (<67 vs. ≥67 years old, P = 0.017, HR = 1.355, 95% CI: 1.057–1.738), tumor size (<7 cm vs. ≥7 cm, P = 0.001, HR = 1.579, 95% CI: 1.202–2.073), Surgery (thyroidectomy vs. non-surgery, P < 0.001, HR = 0.554, 95% CI: 0.401–0.766), radiation therapy (P < 0.001, HR = 0.571, 95% CI: 0.445–0.733) and chemotherapy (P = 0.003, HR = 0.684, 95% CI: 0.531–0.881) were independent prognostic factor for worse OS in stage IVC ATC patients. Surgery combined with adjuvant radiation and chemotherapy exhibited the better overall survival time for 4 months.

Conclusions
Surgery combined with adjuvant radiation and chemotherapy can improve overall survival in stage IVC ATC patients. We recommend surgical approach with fully evaluation combined with radiation therapy and chemotherapy for selected stage IVC ATC patients.
Identification of non-actionable mutations with prognostic and predictive value in patients with advanced or metastatic non-small cell lung cancer
Authors: Provencio-Pulla Mariano , Pérez-Parente Diego , Olson Sara , Hasan Haroon , Balea Begoña Campos , Rodríguez-Abreu Delvys , Piqueras Marta López-Brea , Pal Navdeep , Wilkinson Samantha , Vilas Esther , Ruiz-Gracia Pedro , Cobo-Dols Manuel 
Published: January 2024

Abstract
Introduction
Lung cancer is one of the most prevalent cancers and the leading cause of cancer death. Advanced non-small cell lung cancer (aNSCLC) patients frequently harbor mutations that impact their survival outcomes. There are limited data regarding the prognostic and predictive significance of these mutations on survival outcomes in the real-world setting.

Methods
This observational retrospective study analyzed de-identified electronic medical records from the Flatiron Health Clinico-Genomic and FoundationCore® databases to identify patients with aNSCLC who initiated first-line immune checkpoint inhibitors (ICI; alone or in combination) or chemotherapy under routine care between 2016 and 2021. The primary objectives were to assess the prevalence of non-actionable mutations and to determine their association with overall survival (OS). Real-world progression-free survival (rwPFS) and real-world response (rwR) were investigated as secondary exploratory outcomes.

Results
Based on an assessment of 185 non-actionable mutations in 2999 patients, the most prevalent mutations were TP53 (70%), KRAS (42%), CDKN2A/B (31%), and STK11 (21%). STK11, KEAP1, and CDKN2A/B mutations were significantly associated with lower rwR, shorter rwPFS and OS. KRAS mutations were clinically associated with shorter rwPFS in CIT-treated patients. Subgroup analysis revealed that fast progressors were significantly more likely to harbor STK11, KEAP1, and CDKN2A/B mutations. Accordingly, long-term survivors (LTS) showed a significantly lower prevalence of these mutations.

Conclusion
Our results provide evidence on the prognostic value of STK11, KEAP1, and CDKN2A/B mutations in patients with aNSCLC. Further research is required to better understand the implications of these findings on patient management and future trial design and treatment selection.
Contested Appropriations: Informal Migrant Settlements as Ambiguous Spaces Beyond Temporal Borders
Authors: Benedikt Sebastian 
Published: January 2024

AbstractTemporalities of control are a key element of the migration reception regime: deadlines, waiting times, and limited durations of stay link safe housing to temporal and normative prerequisites. As a result, those who are unable to cross these temporal borders are stuck outside of reception and beyond the temporal nomos of the asylum system, in heightened im-mobility, cut off from protection mechanisms, and in a vicious circle of illegalisation. Based on a literature review and on ethnographic fieldwork conducted in Italy between 2018 and 2023, and from the analytical vantage point on migrant practices of appropriation, this article aims to explore informal camps as ambiguous spaces between coercion and subversion. While informality is used by state authorities to disrupt migrant multiplicities, mobilities, and temporalities, it can at the same time become a loophole for migrants to evade control, deportation, and detention and to pursue their migration projects. Through practices of appropriation, migrants regain not only time and space but also rights that have been denied to them. In doing so, they contest the temporalities of control, demonstrating that time can be “taken” through endured limbo, but that it is still relative and can thus be recoded. Despite presenting informality as an arena of collective renegotiation, the article concludes arguing against a romanticisation of informal encampments, showing that they are subject to politics of violence and abandonment.
Cryogenic Deformation Behaviour of Aluminium Alloy 6061-T6
Authors: Jin Minsoo , Lee Byungju , Yoo Jisung , Jo Yonghee , Lee Seunggun 
Published: January 2024

AbstractAluminium alloy 6061-T6 (AA6061-T6) shows a promising potential for cryogenic structural applications. This alloy exhibits remarkable monotonic tensile properties at low temperatures. However, there is a limited number of studies on the cryogenic deformation behaviour. In this study, both monotonic and cyclic loading were conducted, and various microstructure characterisation techniques were performed to understand influence of cryogenic temperatures on microstructure evolution and deformation behaviour of this alloy. At cryogenic temperatures, the aluminium alloy exhibited superior mechanical properties over those at room temperature. Yield stress, UTS and elongation at failure increased by 18%, 33%, and 53% at 77 K compared to those at room temperature. Such increase in mechanical properties was attributed by the stronger resistance to dislocation movement due to the reduced thermal assistance. Work hardening rate also increased as dynamic recovery was suppressed at lower temperatures. As a result, a high density of dislocations was evenly distributed within grain interior and led to a homogeneous deformation. The test temperature appeared to have a significant influence on fatigue performance; maximum stress response increased by 23% at 108 K with respect to those at room temperature. During cyclic loading, a high number of dislocations was generated to accommodate prescribed strain because of the resistance to dislocation movement including the pinning of dislocations by β’’ precipitates which are known to be sheared at room temperature. Thus, the alloy exhibited an enhanced cyclic hardening behaviour without a noticeable cyclic softening phase. Fatigue life improved by 143% at 108 K with respect to that at room temperature as the homogeneous deformation prohibited localised slip activity and delayed formation of slip bands which act as crack initiation sites. Moreover, the initiation and propagation of secondary cracks at 108 K retarded the propagation of main crack to improve fatigue life.
Graphical Abstract
A Phenomenological Investigation of Experiences of People Who Use YouTube to Access Support for Borderline Personality Disorder
Authors: Monks-Woods Alice , Andriopoulou Panoraia , Grogan Sarah 
Published: January 2024

Abstract
Background
Research suggests that individuals with a mental health diagnosis often engage in social media to access support for their diagnosis. However, there is a lack of information on online usage in those diagnosed with borderline personality disorder (BPD). Furthermore, there is little research using qualitative interviews to examine the use of social media, such as YouTube, for psychological support.

Purpose
The aim of the present study was to explore experiences of YouTube in individuals diagnosed with borderline personality disorder, including its impact on their offline lives.

Methods
Six participants were recruited on social media; all those who contacted the researcher and met inclusion criteria were interviewed. Semi-structured interviews were used, lasting between 40 and 60 min. Data were transcribed verbatim and analysed using interpretive phenomenological analysis.

Findings
The analysis produced two global themes: ‘YouTube as a form of self-help’ and ‘YouTube transforming the self’.

Limitations
All the participants were female, limiting transferability of the findings.

Originality
This paper is the first to show that YouTube could be used in addition to regular support to initiate recovery for those with BPD. It could provide them with a way to reduce self-stigma, enhance self-awareness and learn coping techniques.
P129, a pyrazole ring-containing isolongifolanone-derivate: synthesis and investigation of anti-glioma action mechanism
Authors: Jiang Yining , Wang Yunyun , Zhao Liyan , Yang Wenzhuo , Pan Lin , Bai Yang , Wang Yubo , Li Yunqian 
Published: January 2024

Abstract
Background
Cyclin-dependent kinase-2 (CDK-2) is an important regulatory factor in the G1/S phase transition. CDK-2 targeting has been shown to suppress the viability of multiple cancers. However, the exploration and application of a CDK-2 inhibitor in the treatment of glioblastoma are sparse.

Methods
We synthesized P129 based on isolongifolanone, a natural product with anti-tumor activity. Network pharmacology analysis was conducted to predict the structural stability, affinity, and pharmacological and toxicological properties of P129. Binding analysis and CETSA verified the ability of P129 to target CDK-2. The effect of P129 on the biological behavior of glioma cells was analyzed by the cell counting kit-8, colony formation, flow cytometry, and other experiments. Western blotting was used to detect the expression changes of proteins involved in the cell cycle, cell apoptosis, and epithelial–mesenchymal transition.

Results
Bioinformatics analysis and CETSA showed that P129 exhibited good intestinal absorption and blood–brain barrier penetrability together with high stability and affinity with CDK-2, with no developmental toxicity. The viability, proliferation, and migration of human glioma cells were significantly inhibited by P129 in a dose- and time-dependent manner. Flow cytometry and western blotting analyses showed G0/G1 arrest and lower CDK-2 expression in cells treated with P129 than in the controls. The apoptotic ratio of glioma cells increased significantly with increasing concentrations of P129 combined with karyopyknosis and karyorrhexis. Apoptosis occurred via the mitochondrial pathway.

Conclusion
The pyrazole ring-containing isolongifolanone derivate P129 exhibited promising anti-glioma activity by targeting CDK-2 and promoting apoptosis, indicating its potential importance as a new chemotherapeutic option for glioma.
Research on key technology of packer rubber barrel for integrated fracturing and completion of gas well
Authors: Wang Peng , Cai Meng , Liu Zhaoyi , Ma Wenhai , Li Junliang 
Published: January 2024

AbstractThe staged and layered fracturing technology plays an important role in unconventional tight reservoirs. And the gas well fracturing and completion integration is the core component to realize the fracturing and completion integration process, which can realize the integration of acid fracturing and later drainage production so as to reduce the secondary pollution to the reservoir. The packer rubber barrel’s performance directly affects the long-term effective sealing reliability itself in high temperature and high pressure environment. In this paper, the constitutive model of rubber tested from high temperature and high pressure curing kettle to simulate the high-temperature and highly corrosive environment of the formation. On this basis, the structure of the packer’s shoulder and the protective ring of the rubber barrels are optimized through Abaqus to reduce its stress failure under high pressure, and its corrosion resistance is improved by improving the rubber material. The sealing performance of the packer rubber cylinder under the field underground requirements is tested through laboratory evaluation test and field test. The results show that the protective ring and rubber tube shoulder at 30° angle are a reasonable result of optimization, and the optimized packer can meet the requirements of 154 °C temperature resistance, 79 MPa pressure bearing and long-term effective sealing. The successful development of packer rubber and the integrated analysis process can lay a solid foundation for the realization of integrated fracturing and completion process for exploration and development of deep volcanic or carbonate reservoirs.
Short $$(\textbf{SL}_2\times \textbf{SL}_2)$$-structures on Lie algebras
Authors: Beites Patricia D. , Córdova-Martínez Alejandra S. , Cunha Isabel , Elduque Alberto 
Published: January 2024

Abstract$$\textbf{S}$$
S
-structures on Lie algebras, introduced by Vinberg, represent a broad generalization of the notion of gradings by abelian groups. Gradings by, not necessarily reduced, root systems provide many examples of natural $$\textbf{S}$$
S
-structures. Here we deal with a situation not covered by these gradings: the short $$(\textbf{SL}_2\times \textbf{SL}_2)$$

(

SL
2

×

SL
2

)

-structures, where the reductive group is the simplest semisimple but not simple reductive group. The algebraic objects that coordinatize these structures are the J-ternary algebras of Allison, endowed with a nontrivial idempotent.
Microwave-assisted hydrothermal processing of pine nut shells for oligosaccharide production
Authors: Torrado Ivone , Neves Beatriz Guapo , da Conceição Fernandes Maria , Carvalheiro Florbela , Pereira Helena , Duarte Luís C. 
Published: January 2024

AbstractPine nut shells, a biomass residue from the Mediterranean Pinus pinea pine nut industrial processing, were treated by microwave-assisted autohydrolysis to produce xylo-oligosaccharides. Microwave-assisted processes provide alternative heating that may reduce energy input and increase overall process efficiency. The autohydrolysis treatments were performed under isothermal and non-isothermal operations within a wide range of operational conditions (temperature/reaction times) covering several severity regimes (as measured by the log R0 severity factor). The composition of the autohydrolysis liquors was determined in terms of oligo- and monosaccharides, aliphatic acids and degradation compounds. The process was highly selective towards hemicelluloses hydrolysis and liquid streams containing a mixture of oligomeric compounds (mainly xylo-oligosaccharides) could be obtained under relatively mild operation conditions (190 °C, 30 min) with a maximal oligosaccharides’ concentration of 18.48 g/L. The average polymerization degree of the obtained oligosaccharides was characterised by HPLC, showing that for the optimal conditions a mixture of oligomers with DPs from 2 to 6.
An investigation on the performance of vehicle brake pads developed from Cortaderia selloana based biomass
Authors: Yavuz Hicri , Bayrakçeken Hüseyin , Çengelci Emin , Arslan Turan Alp 
Published: January 2024

Abstract
Nowadays, researchers are making intense efforts to develop biomass-based industrial products. This study developed low-metallic and asbestos-free samples based on Cortaderia selloana (12–15% and 18% ratios), a natural species, to contribute to the brake pad field. The developed samples’ friction coefficient and wear rate experiments were carried out on a brake pad test device with a load of 1 MPa and a disk rotation speed of 6 m/s, according to the TS555 standard. Scanning electron microscopy and electron-dispersive x-ray analysis were performed on the worn surfaces of the samples. According to the results obtained, the wear rate increased while the average friction coefficient decreased in the brake pad samples using 18% Cortaderia selloana content in the sample content. In scanning electron microscopy analysis, primary and secondary plateau formations were observed on the worn surfaces of all samples. At the same time, samples containing 15% and 18% Cortaderia selloana also showed signs of abrasive wear. High friction coefficient and low wear rate are expected for brake pads to be used in automobiles. In general, the friction of brake pads must be within the range, and it is always necessary to balance the friction to avoid driver discomfort. However, except for some racing applications, a high coefficient of friction is only sometimes desirable, which can cause rotor wear problems. As a result of this research, a consistent friction coefficient and low wear rate for the brake pads with the brake pad sample containing 12% Cortaderia selloana.
Train-induced aerodynamic characteristics of vertical sound barriers influenced by several factors
Authors: Qiu Xiaowei , Li Xiaozhen , Zheng Jing , Wang Ming 
Published: January 2024

AbstractInvestigations into the aerodynamic properties of vertical sound barriers exposed to high-speed operations employ computational fluid dynamics. The primary focus of this research is to evaluate the influence of train speed and the distance (D) from the track centerline under various operating conditions. The findings elucidate a marked elevation in the aerodynamic effect amplitude on sound barriers as train speeds increase. In single-train passages, the aerodynamic effect amplitude manifests a direct relationship with the square of the train speed. When two trains pass each other, the aerodynamic amplitude intensifies due to an additional aerodynamic increment on the sound barrier. This increment exhibits an approximate quadratic correlation with the retrograde train speed. Notably, the impact of high-speed trains on sound barrier aerodynamics surpasses that of low-speed trains, and this discrepancy amplifies with larger speed differentials between trains. Moreover, the train-induced aerodynamic effect diminishes significantly with greater distance (D), with occurrences of pressure coefficient (CP) exceeding the standard thresholds during dual-train passages. This study culminates in the formulation of universal equations for quantifying the influence of train speed and distance (D) on sound barrier aerodynamic characteristics across various operational scenarios.