bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal genetic factors in pregnancy loss: Insights from a meta-analysis and effectiveness of whole exome sequencing
Authors: Hadjipanteli Andrea , Theodosiou Athina , Papaevripidou Ioannis , Alexandrou Angelos , Salameh Nicole , Evangelidou Paola , Tomazou Marios , Mavrides Andreas , Fasouliotis Sozos , Anastasiou George , Stavroulis Andreas , Agathokleous Niki , Agathokleous Maria , Tsangarides Stelios , Kallikas Ioannis , Kakoullis Kyriakos , Frakala Sofia , Oxinou Christina , Marnerides Andreas , Athanasiou Emilia , Ourani Sofia , Anastasiadou Violetta C. , Tanteles George , Kousoulidou Ludmila , Sismani Carolina 
Published: February 2025

Spontaneous pregnancy loss commonly occurs during the first trimester and can be caused by various factors including chromosomal abnormalities and submicroscopic aberrations. After the first trimester, the etiology of most pregnancy losses remains undetermined. This study aims to fill this gap by an in-depth investigation of the fetal genome and its effect on pregnancy outcome.
Data from 1016 spontaneously aborted fetuses previously referred for genetic testing (2017–2023) were used for meta-analysis. Fetuses were categorized based on gestational age and genetic test result. Additionally, 35 second-third trimester fetuses, that were spontaneously aborted, terminated or died neonatally, with abnormal ultrasounds and unrevealing routine genetic testing were collected. Trio-based whole-exome sequencing was performed for identification of fetal variants that may have caused the pregnancy loss.
The meta-analysis revealed that 822 of 1016 fetuses (80.91%) were aborted during the first trimester, with 569 of 822 (69.22%) successfully diagnosed using conventional genetic testing. The remaining 194 fetuses (19.09%) were aborted during the second-third trimester. Of the 194 second-third trimester aborted fetuses, 163 (84.02%) lacked genetic diagnosis using conventional testing (karyotype and array-CGH). Aneuploidies were the leading cause of spontaneous pregnancy loss in both first and second-third trimester fetuses followed by polyploidies. Thus, the meta-analysis demonstrated that undiagnosed second-third trimester pregnancy losses are more likely to benefit from further genetic investigation.
Application of whole exome sequencing on second-third trimester pregnancy losses, revealed causative variants in 6 of 33 families (18.18%), in genes linked to Mendelian disorders associated with the phenotypes of interest. Pathogenic findings were identified in two additional families in heterozygosity in genes following autosomal recessive inheritance.
Accurate identification of variants in such genes creates new genotype-in utero phenotype associations, with the prospect of new additions in preconception/prenatal diagnostic panels. This study highlights the importance of whole exome sequencing in resolving undiagnosed pregnancy losses.
Factors affecting prognosis in traumatic cerebral contusions: A protocol for a systematic review and meta-analysis
Authors: Li Chao , Su Zhaoyin , Deng Shulu , Zhang Binhao , Qin Junlong , Wu Kun , Zhao Yanzong , Liu Yao 
Published: February 2025

Background
Traumatic cerebral contusion (CC) is a severe type of injury among traumatic brain injury (TBI) patients. Individuals with traumatic CC typically exhibit rapid deterioration in their condition, leading to increased mortality rates. Despite this, there is a gap in evidence-based research. This study aims to identify the risk factors associated with adverse outcomes in patients with traumatic CC, with a particular focus on relevant biomarkers. Mortality will be the primary outcome, while the Glasgow Coma Scale (GCS) score will be considered as a secondary outcome.

Methods and analysis
We intend to conduct a comprehensive search through multiple Chinese and English repositories, covering the duration from the establishment of these databases up to the current era, in order to pinpoint appropriate studies. Additionally, a manual search of the references within the included literature and other pertinent works will be undertaken. The primary endpoint of this study will be the survival status of patients with traumatic brain contusion. Meta-analysis will be executed using STATA 16.0 (Stata Corporation, College Station, TX). Article selection and data extraction will be performed independently by two reviewers. The assessment of bias risks will be conducted via the Cochrane Collaboration’s tool. Depending on the heterogeneity evaluation, either a fixed-effect model or a random-effects model will be applied. Subgroup and sensitivity analyses will be conducted as needed. The examination of publication bias will be carried out, and the quality of evidence for the primary outcomes will be graded.
Trial registration number: CRD42023389456
A systems analysis and improvement approach to optimizing syringe services programs’ delivery of HIV testing and referrals: Study protocol for a parallel-group randomized controlled trial (SAIA-SSP-HIV)
Authors: Bazzi Angela R. , Roth Alexis M. , Akiba Christopher F. , Huffaker Shelby L. , Patel Sheila V. , Smith Jessica , Laurano Rose , Orme Stephen , Zarkin Gary A. , Morgan-Lopez Antonio , Lambdin Barrot H. 
Published: February 2025

With changing drug supplies and associated drug consumption behaviors, HIV transmission has increased among people who inject drugs in the United States. HIV testing and referrals to effective prevention and treatment services are critical for individual and population health, yet multilevel barriers limit access to HIV testing for this population, even within syringe services programs (SSPs). In this organizational-level interrupted time series randomized controlled trial, we will assess the effectiveness and cost-effectiveness of an implementation strategy, the Systems Analysis and Improvement Approach (SAIA), in optimizing HIV testing and referrals to appropriate clinical services among U.S. SSPs. From 01/12/2023 to 01/07/2025, we will recruit a diverse sample of 32 SSPs nationally that directly provide HIV testing to participants. SSPs will be randomized to the active implementation arm (i.e., SAIA-SSP-HIV) or an implementation-as-usual arm (n = 16 organizations per arm). SAIA-SSP-HIV is a flexible, data-driven implementation strategy designed to help optimize SSPs’ delivery of HIV testing and referrals to appropriate clinical services for HIV prevention (e.g., pre-exposure prophylaxis) and treatment. In the active implementation arm, trained SAIA specialists will guide SSPs through three cyclical steps over 12 months: (1) process mapping to identify organization-specific needs, (2) cascade analysis and prioritization of areas for improvement, and (3) testing solutions through continuous quality improvement. In both arms, we will collect outcome data over 21 months (3-month lead-in period, 12-month implementation period, 6-month sustainment period). We will assess the initial and sustained effectiveness of SAIA and calculate its cost and cost-effectiveness. This trial presents a novel opportunity to test the effectiveness of an organization-level implementation strategy for optimizing the delivery of HIV screening and referrals in community settings that are frequented by an at-risk population. If successful, SAIA-SSP-HIV could be adapted for other infectious or chronic disease care cascades within SSPs.
Trial registration: ClinicalTrials.gov: NCT06025435.
Identifying unmet palliative care needs of nursing home residents: A scoping review
Authors: Crowley Patrice , Saab Mohamad M. , Ronan Isabel , Tabirca Sabin , Murphy David , Cornally Nicola 
Published: February 2025

Introduction
Many nursing home residents do not receive timely palliative care despite their need and eligibility for such care. Screening tools as well as other methods and guidelines can facilitate early identification of nursing home residents unmet palliative care needs.

Aim
To map and summarise the evidence on identifying unmet palliative care needs of nursing home residents.

Methods
Any paper reporting on nursing home residents’ unmet palliative care needs were eligible for inclusion. CINAHL, MEDLINE, Embase, Web of Science, APA PsycINFO, and APA PsycArticles and grey literature were systematically searched over two months, February and March 2024. Data were extracted using data extraction forms. Data were synthesised using descriptive analysis and basic content analysis.

Results
Forty six records were included in this review. Nineteen methods, five screening tools, and four guidelines related to identifying residents unmet palliative care needs were identified. Most methods such as the Minimum Data Set and Palliative Care Needs Rounds were implemented as part of an intervention. Limited evidence was identified on what methods healthcare professionals use in daily practice. In total, 117 non-disease specific indicators for identifying residents unmet palliative care needs were identified, with physical indicators such as pain and weight loss being the most represented.

Conclusion
While developments have been made related to the concept of ‘unmet palliative care needs’, a clear definition is required. Evidence-based standardisation of methods for identifying unmet palliative care needs would ensure timely and equitable access to palliative care for nursing home residents worldwide. Achieving this goal requires incorporating screening for unmet palliative care needs into routine care.
Bovarism’s Neurotic Reflections Across Cultures: A Comparative Literary Case Study in Light of Karen Horney’s Neurosis Theory
Authors: Keflioğlu Engin 
Published: February 2025

Abstract
This study applies Karen Horney’s theory of neurosis as a heuristic framework for analyzing bovarist characters in the literature, offering a comparative literary analysis that integrates psychoanalytic theory with cross-cultural textual examination. By exploring the characters of Emma Bovary in Gustave Flaubert’s Madame Bovary and Ayşen in Refik Halit Karay’s Bugünün Saraylısı, the article illustrates how Horney’s conceptualization of neurosis – specifically, the formation of an idealized self-image, the neurotic need for affection, ambition, and the ultimate descent into hopelessness – can be operationalized to understand the psychological underpinnings of bovarist figures. By situating the neurotic processes of Emma and Ayşen within Horney’s framework, the analysis demonstrates how their psychological conflicts, rooted in early childhood experiences and exacerbated by socio-cultural factors, manifest in self-alienation, external validation-seeking, and ultimately, existential despair. Through a close reading of textual evidence and theoretical integration, the study argues that bovarism exemplifies a literary articulation of neurosis, revealing the intricate relationship between psychological distress and narrative construction. The findings suggest that this interdisciplinary approach can serve as a model for future literary analyses, offering a nuanced perspective on the intersection of psychoanalytic theory and literary studies across different cultural and historical contexts.
Precipitation of terephthalic acid from post-consumer polyethylene terephthalate waste fractions
Authors: Müller Clemens , Franke-Hameke Dirk Wilhelm , Brepohl Esther Laura , Biermann Lars , Eichert Carsten , Scholl Stephan 
Published: February 2025

Abstract
Achieving circularity for post-consumer polymers requires to address and overcome significant challenges and limitations such as the efficient removal of additives, colourants, contamination from usage and undesired chain scission. A very effective approach is offered by back-to-monomer recycling processes that break up the polymer matrix, release contaminants and yield virgin-like monomers as starting material for polymer production. This study used post-consumer and post-production polyethylene terephthalate (PET) which were depolymerized by revolPET® technology. As a reaction intermediate disodium terephthalate is obtained, from which the monomer terephthalic acid (TA) can be recovered through acidic precipitation. In this present study, precipitation with acetic acid and sulfuric acid is assessed regarding the impact on recycled terephthalic acid properties and the purification potential at temperatures up to 90°C. Precipitation at elevated temperatures reduces the yellow discolouration of TA, with acetic acid being more effective. With regard to isophthalic acid (IA), a common co-monomer in PET manufacturing, an increase in temperature could reduce the IA content in TA to 90% of the original content using sulfuric acid. Precipitation with acetic acid reduced IA content to less than 20%. The results of this study deliver a novel approach to integrate the purification into the TA formation step.
Long time behavior of the field–road diffusion model: an entropy method and a finite volume scheme
Authors: Alfaro Matthieu , Chainais-Hillairet Claire 
Published: February 2025

Abstract
We consider the so-called field–road diffusion model in a bounded domain, consisting of two parabolic PDEs posed on sets of different dimensions (a field and a road in a population dynamics context) and coupled through exchange terms on the road, which makes its analysis quite involved. We propose a two-point flux approximation (TPFA) finite volume scheme. In both the continuous and the discrete settings, we prove the dissipation of a quadratic entropy, with some entropy dissipation-entropy relation, leading to the exponential decay in time of the solution towards the stationary state selected by the total mass of the initial data. To deal with the problem of different dimensions in the proof of the entropy dissipation-entropy relation, we artificially “thicken” the road and adapt the proof of the Poincaré–Wirtinger inequality. Numerical simulations confirm and complete the analysis, and raise new issues.
A modified predictor–corrector scheme with graded mesh for numerical solutions of nonlinear Ψ-caputo fractional-order systems
Authors: Songsanga Danuruj , Sa Ngiamsunthorn Parinya 
Published: February 2025

Abstract
The aim of this article is to develop a modified predictor–corrector scheme for solving the system of nonlinear

Ψ

\Psi

-Caputo fractional differential equations with order

0
<
α
<
1

0\lt \alpha \lt 1

. By using the graded mesh and considering the predictor–corrector scheme for

Ψ

\Psi

-Caputo fractional derivative, the numerical solutions of nonlinear

Ψ

\Psi

-Caputo fractional-order systems are derived. Moreover, the error estimations of predictor–corrector scheme with graded mesh are also investigated. Particularly, the accuracy of numerical solutions depended on the function

Ψ

\Psi

and the partition size on graded mesh. Numerical examples for linear and nonlinear fractional differential systems with various kernels and meshes are considered to explain the value and effectiveness of the proposed schemes.
Partitions into two Lehmer numbers in ℤq
Authors: Wang Jiankang , Xu Zhefeng 
Published: February 2025

Abstract
Let ℤq be a complete residue system modulo an odd integer q ≥ 3. The main purpose of this paper is to give an asymptotic formula for the number of representations of an element n ∈ ℤ
q
as sum of two classical Lehmer numbers in ℤq. In addition, we make explicit the known expression for the number of the classical Lehmer numbers.
On nonoscillation of fractional order functional differential equations with forcing term and distributed delays
Authors: Viji James , Alzabut Jehad , Muthulakshmi Velu , Özbekler Abdulah 
Published: February 2025

Abstract
The paper deals with the nonoscillatory solutions of arbitrary noninteger-order neutral equations with distributed delays. Through the use of the LFD (Liouville Fractional Derivative) of order α ≥ 0 on the half-axis and BCP (Banach Contraction Principle), we are able to get the nonoscillation criteria. The obtained results are emphasized with some appropriate examples.
Improvements on the Leighton oscillation theorem for second-order dynamic equations
Authors: Zafer Aǧacik , Akgöl Sibel Doǧru 
Published: February 2025

Abstract
The time scales version of the Leighton oscillation theorem states that if

(*)

∫

t
0

∞

1

a
(
t
)

Δ

t
=

∫

t
0

∞

p
(
t
)

Δ

t
=
∞
,

$$
\int\limits_{t_0}^\infty \frac{1}{a(t)}\,{\Delta}t=\int\limits_{t_0}^\infty {p(t)}\,{\Delta}t=\infty,$$

where a and p are rd-continuous with a(t) > 0 for t ≥ t
0, then every solution of the second-order self-adjoint dynamic equation

(
a
(
t
)

x
Δ

)
Δ

+
p
(
t
)

x
σ

=
0

$$
(a(t)x^\Delta)^\Delta+p(t)x^\sigma=0$$

is oscillatory. The theorem turns into the famous Leighton oscillation theorem when the time scale is taken as the set of real numbers, and its discrete version when the time scale is taken as the set of integers. The divergence of the first improper integral in (∗) means that the dynamic equation is in canonical form. The equation is called noncanonical when the integral is convergent. In this study, we establish an improved version of the Leighton oscillation theorem on time scales that can be applied to both canonical and noncanonical types of dynamic equations. Furthermore, we allow the second improper integral in (∗) to be convergent. In the special case, we derive completely new Leighton-type oscillation theorems for second-order self-adjoint difference equations

Δ

(

a
k

Δ

x
k

)
+

p
k

x

k
+
1

=
0
,

$$
{\Delta}(a_k\Delta x_k)+p_kx_{k+1}=0,$$

where Δ is the forward difference operator, defined by Δxk
= xk

+1
− xk
(the derivative). Examples are given to illustrate the significance of these theorems.
An elementary proof of the generalized Itô formula
Authors: Ondreját Martin , Seidler Jan 
Published: February 2025

Abstract
For one-dimensional semimartingales, the Itô formula can be extended from C
2-functions to C
1-functions with a locally absolutely continuous derivative. We propose a new, different proof of this result, which is simple, straightforward and quite elementary, avoiding in particular the extensive theory of local times for semimartingales.
Asymptotic normality for kernel-based test of conditional mean independence in Hilbert space
Authors: Djonguet Terence Kevin Manfoumbi , Nkiet Guy Martial 
Published: February 2025

Abstract
We propose an estimator of the kernel-based conditional mean dependence measure obtained from an appropriate modification of a naive estimator based on usual empirical estimators. We then get asymptotic normality of this estimator both under conditional mean independence hypothesis and under the alternative hypothesis. A new test for conditional mean independence of random variables valued into Hilbert spaces is then introduced.
Analysis of the sports action recognition model based on the LSTM recurrent neural network
Authors: Chen Ping , Peng Jiangui 
Published: February 2025

Abstract
With the rapid growth of motion data, the traditional motion recognition algorithm is faced with the problem of insufficient processing ability. To solve this problem, a method based on gradient descent optimization (GDO)–long short-term memory (LSTM) is proposed to meet the needs of sports action recognition. Based on the experiment of sports data set of students in Hainan University, the experiments of skipping rope, swimming, skating, and shotput were carried out extensively. The total number of experiments were 77, 94, 72, and 85. The experimental results show that the accuracies of GDO-LSTM in sports action recognition were 98.7, 100, 100, and 94.1%, respectively, which was superior to that of the three-axis gyroscope (80.5, 40.4, 23.6, and 100%). These results show that the algorithm can effectively improve the accuracy of sports action recognition and has wide application potential.
Correlation of Immune Parameters in Breast Cancer Patients Undergoing General Anesthesia: post-hoc Analysis of the TeMP Study
Authors: Kadantseva Kristina K. , Subbotin Valery V. , Yadgarov Mikhail Y. , Korolenok Elizaveta M. , Berikashvili Levan B. , Akchulpanov Roman A. , Karnaukhov Nikolay S. , Korchagina Ksenia S. , Kukina Polina I. , Svitich Oksana A. , Kuzovlev Artem N. , Barmina Anna S. , Likhvantsev Valery V. 
Published: February 2025

Aim: to study the correlation of immune parameters in breast cancer patients undergoing general anesthesia and to evaluate the 1-year overall and recurrence-free survival after surgery depending on general anesthesia technique.Materials and Methods. A post hoc analysis of data from a double-blind, randomized, controlled clinical trial involving 98 patients with operable breast cancer was performed. Patients were divided into two groups: 48 received inhalational anesthesia (IA) and 50 received total intravenous anesthesia (TIVA). Immune parameters (CRP, IgA, IgM, IgG, C3, C4, MMP-9, neutrophil and lymphocyte counts, etc.) were assessed before induction of anesthesia, 1 hour postoperatively, and 24 hours postoperatively. Spearman correlation coefficients and heat maps were used for analysis.Results. In the IA group, significant uniform increases were observed in all immunoglobulin types at 1 and 24 hours postoperatively (all P<0.001; for IgA-IgG, R=0.928; for IgA-IgM, R=0.837; for IgG-IgM, R=0.815). A positive correlation was found between complement components (C3, C4) and immunoglobulins (P=0.011 — 0.023; R=0.313–0.363). In the TIVA group, changes were variable: immunoglobulin levels increased at 1 hour (P<0.001) but decreased at 24 hours (P<0.001). A strong positive correlation was identified between cytotoxic T cells and NK cells (P0.001; R=0.722). Neutrophil count showed no significant correlation with cytotoxic T or NK cells. One year after surgery, both groups demonstrated 100% overall and recurrence-free survival.Conclusion. IA was associated with synchronized changes in humoral immunity components, whereas TIVA resulted in variable immune responses, suggesting potential differences in IA and TIVA effects on the immune system. However, no impact of anesthesia technique on overall or recurrence-free survival was observed. More research is needed to better understand how different anesthetics affect immune function and the potential impact of anesthesia technique on long-term cancer outcomes.