bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting an old relationship：The causal associations of the ApoB/ApoA1 ratio with cardiometabolic diseases and relative risk factors——A Mendelian randomization analysis
Authors: Fu Chao , Liu Dongbo , Liu Qi , Wang Xuedong , Ma Xiaoxue , Pan Hong , Feng Shi , Sun Zhao , Qiao Weishen , Yang Mengyue , Gao Shuang , Ding Hongyu , Huang Xingtao , Hou Jingbo 
Published: October 2023

Abstract
Background
It has been confirmed that the ApoB/ApoA1 ratio is closely associated with the incidence of cardiometabolic diseases (CMD). However, due to uncontrolled confounding factors in observational studies, the causal relationship of this association remains unclear.
Methods
In this study, we extracted the ApoB/ApoA1 ratio and data on CMD and its associated risk factors from the largest European genome-wide association study. The purpose was to conduct Mendelian Randomization (MR) analysis. The causal relationship between the ApoB/ApoA1 ratio and CMD was evaluated using both univariable and multivariable MR analyses. Furthermore, bidirectional MR analysis was performed to estimate the causal relationship between the ApoB/ApoA1 ratio and risk factors for CMD.
Results
In terms of CMD, the increase in the ApoB/ApoA1 ratio was significantly related to ischemic diseases such as ischemic heart disease, major adverse cardiovascular events, ischemic stroke, transient ischemic attack, aortic aneurysm (all p༜0.05), and so on. In multivariate MR analysis, the above results were still valid. Regarding CMD risk factors, a significant bidirectional causality existed between the ApoB/ApoA1 ratio and waist circumference, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol. Meanwhile, the ApoB/ApoA1 ratio also had a strong causality with glucose metabolism indicators, obesity-related indicators, and behaviorally relevant indicators.
Conclusions
This MR study provides evidence supporting the significant causal relationship between the ApoB/ApoA1 ratio and CMD and its risk factors. These findings suggest that the ApoB/ApoA1 ratio may serve as a potential indicator for identifying the risk of developing CMD in participants.
Identification of One-carbon metabolism-related gene signature and Analysis of the role of m6A and miRNAs/circRNAs for colon adenocarcinoma
Authors: Wang Gang , Zhi-Min Zhu , Wang Kun 
Published: October 2023

Abstract
Background: To study one-carbon metabolism-related genes and their association with Colon adenocarcinoma (COAD) prognosis, immune cell infiltration, and search for new therapeutic targets and drugs.
Methods: The univariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) Cox regression for COAD prognosis from The Cancer Genome Atlas (TCGA), and the prognostic efficacy of the one carbon unit and amino acid -related gene signature was assessed using Kaplan–Meier (KM) survival and receiver operating characteristic (ROC) curve analyses. The co-expression of one-carbon metabolism -related genes with miRNAs or circRNAs and M6A-related genes in COAD was analyzed. Using CIBERSORT, and single-sample GSEA (ssGSEA) algorithms, the quantities and types of tumor-infiltrating immune cells were assessed. Potential small-molecule agents were identified using the GDSC database and validated by molecular docking. To verify key core gene expression levels, quantitative real-time polymerase chain reaction (qRT–PCR) assays were conducted.
Results: We identified three one-carbon metabolism -related genes (AHCY, BHMT, SLC38A2) for the prognostic signature of overall survival (OS) for COAD. The binding information between metabolism-related genes, target miRNAs and circRNAs indicated that miR-140-5p and miR-195-5p/ hsa_circ_0071989had a good prediction. The chemotherapeutic agent sensitivity of patients categorized by risk score varied significantly. AHCY and BHMT, SLC38A2 mRNA expression was increased in HCT116 cells, whereas miRNA (miR-140-5p and miR-195-5p) expression was decreased in HCT116 cells.
Conclusion:In summary, we identified and developed a one-carbon metabolism -related gene signature with significant prognostic value of COAD, and AHCY, BHMT, SLC38A2 were positively regulated by the m6A genes in COAD samples. The combination TGX221 with cyclopamin significantly decreased AHCY, BHMT and SLC38A2 via upregulating miR-140-5p and miR-195-5p in HCT116 cells, which benefits COAD patients by informing more precise and effective treatment decisions.
Research on Dunhuang Murals Image Restoration Method Based on Generative Adversarial Network
Authors: Ren Hui , Sun Ke , Zhao Fanhua , Zhu Xian 
Published: October 2023

Abstract
Dunhuang murals are an important part of China's cultural heritage, after more than a thousand years of exposure to the sun and wind, most of these ancient murals have become mottled, with damage such as cracking, mold, and even large-scale detachment. It is an urgent work to restore these damaged murals. The technique of digital restoration of mural images refers to the reconstruction of mural structures and textures to virtually fill in the damaged areas of the image. To solve the problems of incomplete restoration and distortion of local details in the existing digital restoration process, this paper proposes a generative adversarial network model combining a parallel dual convolutional feature extraction depth generator and a ternary heterogeneous joint discriminator. The generator shallow network uses vanilla convolution and dilated convolution to extract image features in parallel while capturing different scale features, and the discriminator consists of a global discriminator, a local discriminator and a pixel-level discriminator, which discriminate the generated images at different levels and granularities. In this paper, we construct the Dunhuang murals dataset and validate our method on this dataset, and the experimental results show that the method of this paper has an overall improvement in the evaluation metrics of Peak Signal-to-Noise Ratio (PSNR) and Image Structural Similarity Measure (SSIM) compared with the comparative methods, and the restored resultant image is more in line with the subjective vision of human beings, which achieves the effective restoration of mural images.
Retrospective study of Cognitive Behavioral Therapy for Obesity modified as FIRE method (CBT-F) in combination with medication for weight loss
Authors: Egoshi Masatoshi , Saito Akira , Nordeng Lena , Takayama Yasuyuki , Furukawa Yutaro 
Published: October 2023

Abstract
Obesity rates continue to rise globally, posing a significant public health concern. Current treatments often lack long-term effectiveness, necessitating the exploration of new approaches. This study examines the effectiveness of a modified treatment method called Cognitive Behavioral Therapy modified as FIRE method (CBT-F), which combines cognitive behavioral therapy with pharmacotherapy. The study involves 62 women seeking weight loss treatment, divided into a CBT-F group and a control group receiving only pharmacotherapy. Anthropometric measures and blood chemistry data were collected over an average follow-up period of 68.5 days. The results demonstrate that the CBT-F group achieved significantly greater weight loss compared to the control group. No notable differences were observed in blood chemistry data. The combination of CBT-F and pharmacotherapy offers a comprehensive and planned approach to obesity treatment by addressing psychological factors and leveraging the effects of medication. Modules specifically designed to handle medication side effects and changes in eating behavior may contribute to treatment success and sustainability. Although this study focused on women, future research should examine the effectiveness of CBT-F in diverse populations. CBT-F shows promise as an alternative or complementary treatment option for individuals who have undergone CBT for extended periods or struggle with lifestyle changes. Overall, the findings suggest that CBT-F, with its shorter treatment duration and immediate effects of pharmacotherapy, holds potential as an effective and sustainable approach to obesity treatment. Further studies are necessary to validate these findings and expand the evidence base for this novel treatment.
Exosomal EGFR and miR-381-3P mediate HPV-16 E7-induced angiogenesis of non-small cell lung cancer
Authors: Zhan Riming , Yu Hua , Zhang Guihong , Ding Qingkai , Li Huan , Li Xiangyong , Tang Xudong 
Published: October 2023

Abstract
Background
Our previous studies have demonstrated that exosomal epidermal growth factor receptor (EGFR) and exosomal miR-381-3P expression were significantly increased in HPV-16 E7-overexpressing non-small cell lung cancer (NSCLC) cells. Moreover, exosomal EGFR was involved in HPV-16 E7-induced EMT in NSCLC cells. In this study, we further investigated the effect of exosomes derived from HPV-16 E7-overexpressing NSCLC cells on angiogenesis and the roles of exosomal EGFR and exosomal miR-381-3P in it.
Methods
The exosomes derived from the stable HPV-16 E7-overexpressing A549 and H460 NSCLC cells (E7 Exo) and empty vector-infected cells (ev Exo) were isolated by ultracentrifugation. Colony formation assay and Transwell assay were performed to observe the effect of E7 Exo on the abilities of colony formation and migration of human umbilical vein endothelial cells (HUVECs). Additionally, cell and animal experiments were used to analyze the effect of E7 Exo on angiogenesis. Furthermore, the roles of exosomal EGFR and miR-381-3p in angiogenesis were explored through the inhibition EGFR activation and exosome secretion or overexpression of miR-381-3p, respectively.
Results
Compared with ev Exo, both A549 E7 Exo and H460 E7 Exo significantly enhanced colony formation and migration abilities of HUVECs. Moreover, E7 Exo dramatically promoted tube-forming abilities cells in vitro (P < 0.01) and angiogenesis in vivo (P < 0.01). The inhibition EGFR activation and exosome secretion of NSCLC cells suppressed HPV-16 E7-induced migration and tube formation of HUVEC cells in vitro (P < 0.01), and significantly deceased the levels the Ang-1 and VEGFA proteins, angiogenesis-related markers (P < 0.01). The tube-forming abilities of HUVECs transfected with miR-381-3p mimics and then treated with E7 Exo were significantly enhanced as compared with cells treated with E7 Exo only (P < 0.01), while transfection of miR-381-3p inhibitor reversed this effect (P < 0.05).
Conclusion
Exosomal EGFR and exosomal miR-381-3p may be involved in HPV-16 E7-induced angiogenesis of NSCLC.
HIV-1 incidence in the era of rapid tests for recent infection in Livingstone District, Zambia
Authors: Simushi Precious , Chiyenu Kaseya O. R. , Choonga Powell , Hamooya Benson M. , Zambwe Mowa , Chipimo Peter J. 
Published: October 2023

Abstract
Objective
HIV incidence is not well documented where health services are delivered as a result failure of better understanding current transmission of HIV in a community. The aim was to determine the incidence of HIV-1 and factors associated with recent infection in Livingstone district using the HIV-1 recent infection testing algorithm, using the Rapid test for recent infection with HIV viral load testing to identify true HIV recent patients infected within 12 months.
Results
This was a laboratory based cross sectional study in which samples of newly diagnosed HIV positive adults sent to LUTH PCR laboratory for Recency testing and HIV VL testing were used. In our study participants, the younger age group were more likely to have been infected in the past 12 months, median age: recently infected 28 (23, 37.5) vs long term 33 (27, 40) p-value = 0.002. Out of the 768 clients subjected to RITA, 18.75% were true HIV recent, with the majority of them being female at 59.51%. 50.74% of the clients classified as recent were virally unsuppressed, p- value =0.000. Mahatima Gandhi clinic had a high number of recent infections relative to other facilities at 17.36%. Majority of the clients were captured under index modality with a percentage of HIV recent patients at 47.22%. Adjusted analysis indicated a significant association between age, HIV VL and recent infection (OR 0.97; 95%CI 0.95-0.99; p- value=0.002) and (OR 0.32; 95%CI 0.22-0.48; p- value =0.000).
A high HIV incidence of recent infection with a 50.74% HIV VL unsuppressed clients was observed suggestive of high HIV transmission rate in the community. The majority of clients were captured under index testing indicating that most clients are less likely to seek medical care for HIV testing. Being virally unsuppressed and age were associated with recent infection. Facilities servicing low income areas may be hot spot zones where preventive and treatment interventions should be prioritized in the district.
A Computational Exploration of Whole Genome Sequences of Klebsiella pneumoniae ST16 for Beta-lactam Resistance and the Discovery of NMD-1 Resistance Gene Inhibitor
Authors: Ibisanmi Tope Abraham , Olowosoke Christopher Busayo , Ayeni Timothy O. , Faleti Ayodele Ifeoluwa 
Published: October 2023

AbstractAntibiotic resistance is a growing concern in healthcare and medicine. This research focuses on studying the sequences of Klebsiella pneumoniae ST16 from the NCBI database. The goal is to identify genes that cause resistance to antibiotics and potentially find substances that can inhibit them. The study discovered genes that contribute to resistance against types of antibiotics such as macrolides, fluoroquinolones, aminoglycosides, sulphonamides, rifampicin, trimethoprim, and beta-lactams. Notable genes identified include blaTEM 1B, blaCTX M 15, and blaNDM-1. Furthermore, changes were observed in the acrR, ompK36, and gyrA genes, along with alterations in the corresponding acids, which are associated with resistance. The analysis also examined the alleles at each locus and found that FIA had a new allele. Molecular docking results revealed that baicalein showed docking scores of -7.7 kcal/mol when binding with New Delhi Metallo 1 (NDM-1) related to beta-lactams. The RMSD plot demonstrated behavior for both Baicalein and Adapalene complexes of NDM-1 over a 50 ns simulation period. However, the higher Rg value for the NDM-1 Beta-Lactamase 1-Adapalene complex indicates it may have slightly more flexibility compared to the NDM-1 Beta-Lactamase 1-Baicalein complex. Summarily, the study offers information about how antibiotic resistance works in relation to the NDM-1 gene and its role in beta-lactam resistance based on analysis which reveals that beyond baicalein, other excellent bioactive (taxifolin, and ellagic acid) strongly bind to the NDM 1 domain and can be further investigated experimentally.
Water-Dissociation Catalysis Near the Reversible Limit in Bipolar Membrane Electrolyzers
Authors: Boettcher Shannon ,   Sayantan Sasmal1, Chen Lihaokun , Sarma Prasad , Traenkle Olivia , Simons Casey , Wells Kacie , Spontak Richard 
Published: October 2023

Abstract

The voltage penalty encountered when driving water dissociation (WD) at a high current density represents a major obstacle in the commercialization of existing bipolar-membrane (BPM) technology for energy devices. Here we show that three materials descriptors, including the electrical conductivity, microscopic surface area, and (nominal) surface-hydroxyl coverage, effectively control the kinetics of WD in BPMs. Using these descriptors and optimal mass loading, we design new earth-abundant WD catalysts based on nanoparticle SnO2 synthesized at low temperature that exhibit exceptional performance by driving the WD reaction in a BPM electrolyzer at the remarkably low WD overvoltage (ηwd) of 100 ± 20 mV at 1.0 A cm−2. We demonstrate this new catalyst works equivalently well with hydrocarbon proton-exchange layers as it does with fluorocarbon-based Nafion, thus providing new pathways to commercializing advanced bipolar membranes for a broad array of electrolysis, fuel-cell, and electrodialysis applications.
Enhancement of tripartite entanglement via periodically-modulated fields with an atom-assisted optomechanical system
Authors: Wen Jiaxin , LU Yi , Li Zhenghong , Yang Xihua 
Published: October 2023

Abstract
We propose a model for controlling and enhancing the entanglement between the two cavity fields and mirror with a hybrid optomechanical system consisting of Λ-type three-level 85Rb atomic ensembles driven by two externally modulated laser fields. When one (another) cavity mode is driven at the red (blue) mechanical sideband and both cavity modes are blue-detuned by the mechanical frequency to the respective atomic resonant transitions, the dynamic coupling control of the cavity field and mirror can be realized by periodically modulating the amplitudes of the two incident laser fields. Compared to the unmodulated case, the periodic modulation of the laser fields in a cavity-optomechanical system embedded with a small number of atoms has the capability to enhance the entanglement between the two cavity fields and mirror. This scheme provides a new approach to the generation and control of entanglement in cavity-optomechanical systems.
An Assessment of Sociotechnical Transition in Marine Warranty Survey Practice: Case of West Africa’s Marine and Cargo Project Management Against Risk
Authors: Sackey Anthony D. , Lamptey Benjamin L. , Afful Priscilla A. , Barwuah Kwasi G. , Amoak Steven , Sackey Barbara K. , Amedake Marilyn A.Y. , Obuya Ojulu N. , Eshun Isaac , Nyarko Enock Otoo , Obeng-Adjapong Felix 
Published: October 2023

Abstract
As in Figure 1, the study proceeds to investigate and characterize the nature of the sociotechnical systems and transitions during operation in the maritime industry spared by the COVID-19 pandemic –comparing and examining cause and effect variables setting forth the relationship of complexity within the transition in the Gulf of Guniea area. The study also examines and contrasts best practices while drawing on the lessons learned. A case study approach was implemented where initial data gathering was achieved through a targeted survey. This was followed by a select interview to examine specific concerns arising from the survey outcome before a field observation was carried out.
The study finds respondents highlighted the emerging need for green energy towards ecological sustenance as highly ranked among factors rapidly spearheading socio-technical transition in the maritime and offshore energy industry in West Africa. 67 percent also viewed the health crisis as a positive force in the sociotechnical transition in the maritime and offshore energy industry. These findings agreed with researchers who found that during the pandemic’s lockdown and restrictions, carbon emissions across the globe were reduced by 5.4 percent. Again, 87 percent found the need to be physically present on the survey site critical to safe operations and success. This notwithstanding, the period saw the introduction and scaling of remote marine surveys. Finally, 81.4 percent of respondents found the use of remote technology on the marine survey site to be essential to operations success while limiting the movement of the attending surveyor on site.
Interest rate law: how low wages makes the loanable fund Market a sustainable one
Authors: boughabi houssam 
Published: October 2023

Abstract
The fact Markets don’t lead to efficiency while there are more habits of speculating around currencies and interest rate is not taken as a lemma, this article embraces the classical doctrine, the interst rate is shown to increase if workers are pessimist about future wages E[wT /Ft ] = 0, arguably risk in the Stock market if we suppose it is fractional has more incentives for the loanable fund Market while it remains to be seen for what reason interest rate has come through risky assets to define a benchmark for wealth
JEL Classification. B21, E41
PINN-CHK: Physics-informed neural network for high-fidelity prediction of early-age cement hydration kinetics
Authors: Rahman Md Asif , Zhang Tianjie , Lu Yang 
Published: October 2023

Abstract

Cement hydration kinetics, characterized by heat generation in early concrete stages, poses a modeling challenge. This study introduces the Physics-Informed Neural Network for Cement Hydration Kinetics (PINN-CHK) to investigate early-age temperature rises in cement paste. PINN-CHK leverages data-driven solutions to craft a high-fidelity prediction model, encompassing material properties and maturity functions in cement hydration. Trained on heated cement paste data, it simultaneously fits experimental results and underlying physics, yielding a mesh-free simulation. Incorporating governing partial differential equations, initial and boundary conditions into its loss function, PINN-CHK architecture undergoes rigorous benchmark testing, demonstrating unparalleled predictive accuracy compared to conventional deep learning methods. It excels in forecasting complete temperature fields during spatial-temporal cement hydration, achieving a remarkable relative L2 error as low as 0.00341. PINN-CHK achieves exceptional convergence and accuracy with only 5% of the training data, ushering in a new era in this crucial field. This innovative approach bridges the gap between theory and practice, offering an attractive alternative to conventional finite element solvers for enhanced comprehension of cement hydration kinetics and concrete maturity and strength development in cement-based materials.
Effect of direct-contact ultrasonic-infrared combined drying on the drying characteristics and quality of ginger
Authors: Feng Zhenhua , Zhang Minmin , Guo Lanping , Shao Rencai , Wang Xiao , Liu Feng 
Published: October 2023

Abstract
In this study, direct-contact ultrasonic-infrared combined drying method was used to dry the ginger, including the water loss process, color difference, water migration law, gingerol content, volatile components and antioxidant activity of ginger under different ultrasonic frequencies, drying temperatures and slice thicknesses. The results of low field nuclear magnetic resonance (LF-NMR) and gas phase ion migration chromatography (GC-IMS) analysis showed that compared with single infrared drying, ultrasonic combined with infrared drying accelerated the free water migration rate, shortened the drying time (from 280 min to 160 min), and reduced the loss of gingerol and volatile components in ginger. After ultrasonic intervention, the natural active ingredients and antioxidant activity of the samples were significantly increased (p < 0.05). The results of weighted comprehensive scoring showed that the infrared temperature of 50 °C and the ultrasonic frequency of 21 KHz were the optimal parameters for the direct-contact ultrasound-infrared combined drying of ginger slices, and the overall quality of ginger slices was the best under these conditions. This drying technology has certain reference significance for the drying process of ginger slices.