bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apocalyptic Ideology
Authors: Tesei Tommaso 
Published: November 2023

Abstract
This chapter is dedicated to the apocalyptic ideology presented in the Neṣḥānā d-Aleksandrōs and its relationship to pro- and anti-imperial sentiments in earlier literature. It highlights the Syriac author’s unprecedented emphasis on the eschatological role of the Roman Empire and on his innovative conceptualization of Byzantium as a kingdom destined to establish a Christian cosmocracy in preparation for the return of the Messiah and the establishment of God’s Kingdom. At the same time, it emphasizes the connection between the apocalyptic vision articulated in the Neṣḥānā and that outlined two centuries earlier in Aphrahat’s Demonstrations. It argues that the author of the Neṣḥānā expanded upon the anti-Sasanian character of Aphrahat’s reading of Daniel not only as a consequence of the renewed hostilities between the two empires, but also in reaction to increasing rapprochement between the Sasanian crown and the Church of the East. This reading of sixth-century sources indicates that contemporary Persian Christians developed an understanding of Daniel’s apocalyptic visions that sought to confer upon the Sasanian Empire a special role in sacred history and a dignity equal to that attributed to the Roman Empire by Byzantine authors. In reaction to these trends current among Persian Christians, the author of the Neṣḥānā developed his highly politicized and militant hermeneutic of Daniel 2, 7, and 8—which predicts the collapse of the Sasanian kingdom.
The Crown, the Throne, and the Last Roman Emperor
Authors: Tesei Tommaso 
Published: November 2023

Abstract
This final chapter treats the second part of Alexander’s prayer, specifically the king’s surrender of his crown and throne as a ceremonial act prior to the return of the Messiah. The chapter compares this motif to the well-known Last Roman Emperor legend, and compares the passage in the Neṣḥānā with sections from the Apocalypse of Ps.-Methodius and the so-called Tiburtine Sibyl where the Last Emperor theme appears. The chapter argues that the Neṣḥānā contains the first recorded version—although in an embryonical stage—of this legend, and connects the scene of the surrender of the crown and throne in the Neṣḥānā to late antique allegorical representations of the idea of translatio imperii, by means of the symbols of the heavenly crown and the throne of the kosmokrator. The chapter argues that the Syriac author draws upon this semiotic universe to again express the idea that Rome was destined to become a cosmocratic power with the goal to rebut representations of Persian dynasts as universal kings.
Volatile Compounds Emitted by Plant Growth–Promoting Fungus Tolypocladium inflatum GT22 Alleviate Copper and Pathogen Stress
Authors: Chiang Chih-Yun , Chang Ching-Han , Tseng Tzu-Yun , Nguyen Van-Anh Thi , Su Pei-Yu , Truong Tu-Trinh Thi , Chen Jing-Yu , Huang Chung-Chih , Huang Hao-Jen 
Published: November 2023

Abstract
Previous studies on the intricate interactions between plants and microorganisms have revealed that fungal volatile compounds (VCs) can affect plant growth and development. However, the precise mechanisms underlying these actions remain to be delineated. In this study, we discovered that VCs from the soilborne fungus Tolypocladium inflatum GT22 enhance the growth of Arabidopsis. Remarkably, priming Arabidopsis with GT22 VCs caused the plant to display an enhanced immune response and mitigated the detrimental effects of both pathogenic infections and copper stress. Transcriptomic analyses of Arabidopsis seedlings treated with GT22 VCs for 3, 24 and 48 h revealed that 90, 83 and 137 genes were differentially expressed, respectively. The responsive genes are known to be involved in growth, hormone regulation, defense mechanisms and signaling pathways. Furthermore, we observed the induction of genes related to innate immunity, hypoxia, salicylic acid biosynthesis and camalexin biosynthesis by GT22 VCs. Among the VCs emitted by GT22, exposure of Arabidopsis seedlings to limonene promoted plant growth and attenuated copper stress. Thus, limonene appears to be a key mediator of the interaction between GT22 and plants. Overall, our findings provide evidence that fungal VCs can promote plant growth and enhance both biotic and abiotic tolerance. As such, our study suggests that exposure of seedlings to T. inflatum GT22 VCs may be a means of improving crop productivity. This study describes a beneficial interaction between T. inflatun GT22 and Arabidopsis. Our investigation of microorganism function in terms of VC activities allowed us to overcome the limitations of traditional microbial application methods. The importance of this study lies in the discovery of T. inflatun GT22 as a beneficial microorganism. This soilborne fungus emits VCs with plant growth–promoting effects and the ability to alleviate both copper and pathogenic stress. Furthermore, our study offers a valuable approach to tracking the activities of fungal VC components via transcriptomic analysis and sheds light on the mechanisms through which VCs promote plant growth and induce resistance. This research significantly advances our knowledge of VC applications and provides an example for further investigations within this field.
Bottom-up effects of variable winter weather conditions on phytoplankton dynamics in an enclosed bay: implications for ecological responses to climate change
Authors: Suzuki Keita W , Dinh Hanh T 
Published: November 2023

Abstract
To investigate phytoplankton dynamics in response to variable winter weather conditions along the Sea of Japan, we conducted daily sampling in enclosed Maizuru Bay in five winters and found distinctive differences between 2016/2017 and 2018/2019. A clear diatom bloom occurred through the water column in moderately cold/snowy 2016/2017, whereas in exceptionally warm/snow-free 2018/2019 a small peak of dinoflagellates occurred only in the subsurface. Nutrient concentrations changed drastically depending on freshwater discharge and diatom growth in 2016/2017, showing a contrast with constant nutrient concentrations in 2018/2019. Copepod densities were ~10 times higher in 2016/2017 than in 2018/2019, indicating bottom-up effects in 2016/2017. As the absence of a diatom bloom from 2018/2019 can be attributed neither to nutrient limitation nor to grazing pressure, we hypothesize that wind mixing is a key factor triggering a diatom bloom. Within the five winters, clear diatom blooms were found only after strong winds and heavy precipitation including snowfall. Wind mixing would possibly promote the germination/rejuvenation of viable resting stage cells as inocula for a diatom bloom, while the growth and maintenance are supported by nutrient supply through freshwater discharge. In Maizuru Bay, winter production is likely activated by harsh weather conditions characteristic of this region.
Corals and sponges are hotspots of reactive oxygen species in the deep sea
Authors: Taenzer Lina , Wankel Scott D , Kapit Jason , Pardis William A , Herrera Santiago , Auscavitch Steven , Grabb Kalina C , Cordes Erik , Hansel Colleen M 
Published: November 2023

Abstract
Reactive oxygen species (ROS) are central to diverse biological processes through which organisms respond to and interact with their surroundings. Yet, a lack of direct measurements limits our understanding of the distribution of ROS in the ocean. Using a recently developed in situ sensor, we show that deep-sea corals and sponges produce the ROS superoxide, revealing that benthic organisms can be sources and hotspots of ROS production in these environments. These findings confirm previous contentions that extracellular superoxide production by corals can be independent of the activity of photosynthetic symbionts. The discovery of deep-sea corals and sponges as sources of ROS has implications for the physiology and ecology of benthic organisms and introduces a previously overlooked suite of redox reactants at depth.
Electroconductivity, a regenerative engineering approach to reverse rotator cuff muscle degeneration
Authors: Saveh-Shemshaki Nikoo , Barajaa Mohammed A , Otsuka Takayoshi , Mirdamadi Elnaz S , Nair Lakshmi S , Laurencin Cato T 
Published: November 2023

Abstract
Muscle degeneration is one the main factors that lead to the high rate of retear after a successful repair of rotator cuff (RC) tears. The current surgical practices have failed to treat patients with chronic massive rotator cuff tears (RCTs). Therefore, regenerative engineering approaches are being studied to address the challenges. Recent studies showed the promising outcomes of electroactive materials (EAMs) on the regeneration of electrically excitable tissues such as skeletal muscle. Here, we review the most important biological mechanism of RC muscle degeneration. Further, the review covers the recent studies on EAMs for muscle regeneration including RC muscle. Finally, we will discuss the future direction toward the application of EAMs for the augmentation of RCTs.
Dental-derived stem cells in tissue engineering: the role of biomaterials and host response
Authors: Yuan Weihao , Ferreira Luiza de Almeida Queiroz , Yu Bo , Ansari Sahar , Moshaverinia Alireza 
Published: November 2023

Abstract
Dental-derived stem cells (DSCs) are attractive cell sources due to their easy access, superior growth capacity and low immunogenicity. They can respond to multiple extracellular matrix signals, which provide biophysical and biochemical cues to regulate the fate of residing cells. However, the direct transplantation of DSCs suffers from poor proliferation and differentiation toward functional cells and low survival rates due to local inflammation. Recently, elegant advances in the design of novel biomaterials have been made to give promise to the use of biomimetic biomaterials to regulate various cell behaviors, including proliferation, differentiation and migration. Biomaterials could be tailored with multiple functionalities, e.g., stimuli-responsiveness. There is an emerging need to summarize recent advances in engineered biomaterials-mediated delivery and therapy of DSCs and their potential applications. Herein, we outlined the design of biomaterials for supporting DSCs and the host response to the transplantation.
Defining Rochester’s Canon in the Eighteenth Century: The Role of Bragge and Curll
Authors: Fisher Nicholas 
Published: November 2023

Abstract
Benjamin Bragge and Edmund Curll published one of the most popular poetry collections of the eighteenth century: The Miscellaneous Works of the Right Honourable the late Earls of Rochester and Roscommon. Originally produced by Bragge in 1706, then reissued the following year under Curll’s imprint, its first part initiated what David Vieth termed the C series of Rochester’s collected poems that enjoyed at least 25 iterations until c.1798. The inaccuracy of the title—no place was found for Rochester’s play Valentinian, his letters, his lyrics or the Alexander Bendo advertisement—was compounded not only by the absence of any texts scholars now perceive to be authoritative but by incorrect attributions for three-quarters of its predominantly libertine and satiric matter, the majority of which, surprisingly, had already been printed under Rochester’s name. Curll published two further editions which continued Bragge’s emphasis and increased the publications’ attraction for the unsophisticated reader. From 1718 the miscellany was published anonymously, perhaps initially under Curll’s direction, and the now settled contents formed the basis on which Rochester’s poetry was understood and appreciated. Despite Vieth’s accurate definition of the canon in 1968, the record of the Bragge-Curll misattributions continues to impede an accurate public perception of Rochester’s poetic achievement.
Clinical Assessment Interview for Negative Symptoms (CAINS): A Systematic Review of Measurement Properties
Authors: Wehr Sophia , Weigel Lucia , Davis John , Galderisi Silvana , Mucci Armida , Leucht Stefan 
Published: November 2023

Abstract

Background and Hypothesis
Negative symptoms are very important for the overall loss of functioning observed in patients with schizophrenia. There is a need for valid tools to assess these symptoms.

Study Design
We used the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) systematic review guideline to evaluate the quality of the clinical assessment interview for negative symptoms (CAINS) as a clinician-rated outcome measurement (ClinROM).

Study Results
The search strategy resulted in the retrieval of 13 articles, 11 of which were included in this evaluation. In terms of risk of bias, most articles reported on measures of internal consistency and construct validity, which were overall of good quality. Structural validity, reliability, measurement error, and cross-cultural validity were reported with less than optimum quality. There was a risk of bias in ClinROM development. According to the updated criteria of good measurement properties, structural validity, internal consistency, and reliability showed good results. In contrast, hypothesis testing was somewhat poorer. Results for cross-cultural validity were indeterminate. According to the updated GRADE approach from the COSMIN group the scale received a moderate grade.

Conclusions
The COSMIN standard allows a judgment of the CAINS as an instrument with the potential to be recommended for use, but which requires further research to assess its quality, in particular in the domains of content validity, internal consistency, and cross-cultural validity.
Nicotinamide Riboside Modulates HIF-1 Signaling to Maintain and Enhance Odontoblastic Differentiation in Human Dental Pulp Stem Cells
Authors: Zhan Peimeng , Zhang Xinfang , Xie Zhuo , Chen Lingling , Huang Shuheng , Huang Qiting , Lin Zhengmei , Wang Runfu 
Published: November 2023

Abstract
Human dental pulp stem cells (hDPSCs) play a vital role in the regeneration of the pulp-dentin complex after pulp disease. While the regeneration efficiency relies on the odontoblastic differentiation capacity of hDPSCs, this is difficult to regulate within the pulp cavity. Although nicotinamide riboside (NR) has been found to promote tissue regeneration, its specific role in pulp-dentin complex regeneration is not fully understood. Here, we aimed to explore the role of NR in the odontoblastic differentiation of hDPSCs and its underlying molecular mechanism. It was found that NR enhanced the viability and retarded senescence in hDPSCs with higher NAD+/NADH levels. In contrast to the sustained action of NR, the multi-directional differentiation of hDPSCs was enhanced after NR pre-treatment. Moreover, in an ectopic pulp regeneration assay in nude mice, transplantation of hDPSCs pretreated with NR promoted the formation of a dentin-like structure surrounded by cells positively expressing DMP-1 and DSPP. RNA-Seq demonstrated inhibition of the HIF-1 signaling pathway in hDPSCs pretreated with NR. The number of HIF-1α-positive cells was significantly decreased in hDPSCs pretreated by NR in vivo. Similarly, NR significantly downregulated the expression of HIF-1α in vitro. The findings suggested that NR could potentially regulate hDPSC odontoblastic differentiation and promote the development of innovative strategies for dental pulp repair.
Entropy Meets Physiology: Should We Translate Aging as Disorder?
Authors: Tatullo Marco 
Published: November 2023

Abstract
Aging is characterized by an alteration of several physiological processes and biological pathways that leads to an increased susceptibility to age-related diseases and death. Normally, multipotential stem/progenitor cells may contribute to tissue homeostasis, and to minimize the age-depending DNA damage. Scientific research has demonstrated that aging induces several complex changes affecting even the mesenchymal stromal/stem cells (MSCs) ability to self-renew, differentiate, and immunomodulate the human tissues, causing further alterations in the local microenvironment. Cellular senescence can thus be considered as an overall response to several damages. Accordingly, aging seems to create the proper conditions to decrease the tissue’s metabolic performance, and the cell-to-cell communication, resulting in a progressive tissue destruction; on the other hand, the MSCs functions appear to be severely reduced. This concise review summarizes the main alterations affecting the MSCs during aging, and it also explains the role of inflammation as a key player in age-related syndromes. The hypothesis is to suggest a parallelism between the thermodynamic concept of “entropy” and biological aging, speculating that both can increase within irreversible systems and both lead toward an irreversible disorder; so, the question is: should we translate aging as disorder?
The effect of different implant programs on beef × dairy steer feedlot growth performance and carcass characteristics
Authors: Wesley K R , Word A B , Maxwell C L , Holland B P , Karr K J , Hutcheson J P , Walter L A J , Johnson B J 
Published: November 2023

AbstractThe objective of this study was to evaluate potency and timing of trenbolone acetate (TBA) administration on live performance and carcass characteristics of beef × dairy steers. A total of 6,895 beef × dairy steers [initial body weight (BW) = 157 ± 5.2 kg] were allotted into 30 pens, with pen as the experimental unit. Each pen was randomly assigned one of three implant treatments: 1) Revalor-IS (IS) at d 0, IS at d 80, and Revalor-XS (XS) at d 160 (IS/IS/XS); 2) Ralgro at d 0, IS at d 80, and XS at d 160 (Ral/IS/XS); or 3) Encore at d 0 and XS at d 160 (Enc/XS). Steers were blocked by arrival date, each pen was terminally sorted in three ways at 257 ± 22 days on feed and harvested at 329 ± 25 days on feed. For live and carcass outcomes, fixed effect of implant treatment and random effect of block was evaluated. Data are reported on a deads and removals out basis. Removals, morbidity, and mortality were similar (P ≥ 0.45). Steers administered TBA prior to d 160 were 5.8 kg heavier (P = 0.03) than Enc/XS steers at d 160. Final BW was not different (P = 0.78). Early administration of a TBA-containing implant resulted in an increased prevalence of bullers [2.40%, 5.18%, 6.86% (for Enc/XS, Ral/IS/XS, and IS/IS/XS) respectively; P &lt; 0.01]. Dry matter intake (DMI) was 2.3% greater (P &lt; 0.01) in steers administered Enc/XS compared to IS/IS/XS; however, DMI as a percentage of BW, average daily gain, and feed efficiency were not different (P ≥ 0.12). Dressing percentage, hot carcass weight, heavy carcass occurrence, Longissimus muscle area, and 12th rib fat thickness were similar among all steers (P ≥ 0.28). Marbling score tended to be greatest for Enc/XS and Ral/IS/XS (P = 0.09). Enc/XS graded a greater proportion of USDA Prime and fewer USDA Select carcasses than IS/IS/XS (P &lt; 0.05). Enc/XS and Ral/IS/XS tended (P = 0.09) to have more USDA Yield Grade (YG) 1 carcasses. While delayed administration or decreased total potency of TBA-containing implants may decrease buller incidence and improve Quality Grade, few differences were observed in live or carcass outcomes.
New approaches build upon historical studies in dermal toxicology
Authors: Williams Faith M 
Published: November 2023

Abstract
These are my personal reflections on the history of approaches to understanding dermal toxicology brought together for the Paton Prize Award. This is not a comprehensive account of all publications from in vivo studies in humans to development of in vitro and in silico approaches but highlghts important progress. I will consider what is needed now to influence approaches to understanding dermal exposure with the current development and use of NAMs (new approach methodologies).
Perspectives Towards Collective Action for Pest and Disease Management in Vineyards in the Western United States
Authors: Lowder Sarah R. , Moyer Michelle M. , Cooper Monica L. , Pscheidt Jay , Mahaffee Walter F. 
Published: November 2023

An individual grower's response to pests and diseases in their vineyard can have consequences for an entire growing region. Collective action strategies can help align grower responses to achieve better regional disease control. Ways in which we identify, approach, and address manager opinions regarding cooperative management efforts influence the success of collective action strategies. A Q-method survey was conducted to investigate the adoption obstacles of wine grape growers to regionally collective actions for managing pests and diseases. Qualitative information from the western United States ( n = 17 participants) was used to generate 36 statements describing opinions on collective management action and general disease management. A second set of grape producers ( n = 59) was asked to rank these statements relative to each other. Participants perceived that collective management action would be worth the extra associated time or costs. Four prominent archetypal perspectives arose from the Q-method analysis, explaining 66% of the variance in expressed opinions. Archetypes were termed “The Cooperators” (14 of 59), “The Quasi-Individualists” (9 of 59), “The Mid-Level Pragmatists” (8 of 59), and “The Bottom-Line Focused” (5 of 59). These groups were split across the demographic information collected; archetypes explained more variation between responses than demographic information. Overall, participants were likely to agree that cooperation was important, but they were more concerned about their individual vineyard economic and crop health concerns, thus suggesting that if outreach professionals want to increase the likelihood of grape growers participating in collective pest management actions, they should emphasize the individual benefits of participation. [Formula: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 “No Rights Reserved” license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2024.