bluuebunny/crossref_metadata_2025_split huggingface dataset:
Location choice of cross-border mergers and acquisitions of port and shipping service enterprises in China: characteristics, process and influencing factors
Authors: Jiang Ziran , Chen Yijie 
Published: January 2025

Abstract

Cross-border mergers and acquisitions (M&A) is one of the main ways for multinational enterprises to access international capital, explore international markets, and participate in global operations. Based on defining the connotation of port and shipping service enterprises (PSSEs), this paper takes the cross-border M&As of PSSEs in China as a research case, and uses spatial analysis technology and conditional Logit model to study the spatial distribution characteristics and main driving factors of the 202 cross-border M&As of PSSEs from 1993 to 2021. Research results are as follows: (1) Cross-border M&As of PSSEs in China are generally divided into four stages: the proximity layout before 2000, the localized agglomeration in 2001–2008, the diffusion distribution in 2009–2016, and the steady expansion from 2017 to the present. (2) The cross-border M&As shows a northeast-southwest direction, and its center of gravity shows a clear trend of moving westward. (3) Overall, the cross-border M&As exhibits an agglomeration trend. From 2001 to 2008, there was no significant correlation. From 2009 to 2016, a negative correlation was observed, while a positive correlation appeared after 2017. These patterns align with the timeline of major national strategies. (4) Among the driving factors affecting the location choice of cross-border M&As, market size of the host country, economic freedom, shipping scale, liner transportation connectivity and institutional distance present a positive impact, while road network density, informatization level and proportion of high-tech product exports present a significant negative impact, and the impact of geographical distance is not significant.
Factors related to required excess energy for weight gain in patients with anorexia nervosa under strict behavioral control: a study in a Japanese medical prison
Authors: Suzuyama Chie Aso , Takakura Shu , Takii Masato , Kishimoto Junji , Suematsu Takafumi , Toda Kenta , Yamashita Makoto , Hata Tomokazu , Sudo Nobuyuki 
Published: January 2025

Abstract

Background
This study aimed to establish the amount of excess calories required for a weight gain of 1 kg in the recovery period of patients with anorexia nervosa (AN) and to identify factors influencing weight gain.
Methods
Forty-one patients with AN in a Japanese medical prison were included in the study. All the data were collected from the medical charts. Body composition was measured using multifrequency bioelectrical impedance devices (InBody 770®) and body weight. Daily caloric intake was determined by calculating the amount of leftover food and resting energy expenditure was calculated using Scalfi's formulation. These were then used to calculate daily excess energy and excess energy for 1-kg weight gain (EE1). In addition, we investigated the relationship between EE1 and initial body composition values, body mass index, and AN subtype.
Results
Of the 41 patients, two had EE1s that we considered outliers. Excluding these, the mean EE1 was 12776.8 kcal/kg with large individual differences observed (range: 6636–22064 kcal/kg). Significant associations were noted between EE1 and body fat mass, body fat percentage, soft lean percentage, and body water ratio. Moreover, patients with BFM ≤ 3 kg (p = 0.003), BFP ≤ 8% (p = 0.008), SLP > 85% (p = 0.011), and BWR > 0.665 (p = 0.011) had higher mean EE1s.
Conclusions
Patients with AN may require more calories than healthy women, particularly patients with less fat and more muscle who may require a greater energy intake for weight gain. (234/350words)
Barriers to Effective Insecticide-Treated Nets (ITN) Usage in Rural Northern Nigeria: Behavioural and Gender Perspectives
Authors: Audu Michael , Adekunle Osuolale Oludayo , Uchenwoke Caroline , Agabus Jummai 
Published: January 2025

Abstract

Malaria remains a significant public health challenge in Nigeria, accounting for approximately 27% of malaria cases and 32% of malaria deaths worldwide. Insecticide-treated nets (ITNs) are among the most effective and cost-efficient interventions for malaria prevention. They reduce the disease’s prevalence and mortality by offering a physical barrier and insecticidal protection against mosquitoes. Despite distributing Insecticide-Treated Nets (ITNs) as part of Nigeria’s malaria control strategies, utilization remains low in rural areas. This study focuses on rural populations and examines the behavioural factors influencing ITN usage in Sokoto, Kebbi, and Zamfara States. Using a mixed-methods approach, quantitative data were collected from 600 households (200 per state) via structured surveys, while qualitative insights were gathered through focus group discussions.
Findings indicate that 72% of households own at least one ITN, but only 45% reported consistent usage. Key barriers to ITN adoption include misconceptions about malaria transmission (32%), discomfort due to heat (28%), and cultural beliefs (24%). Socioeconomic factors such as low income and limited education levels further hinder consistent ITN use. Qualitative findings reveal that women’s decision-making power significantly influences ITN utilization, while myths, such as ITNs causing infertility, discourage their use.
The study concludes that improving ITN utilization in rural Nigeria requires addressing behavioural barriers through targeted community education, gender-sensitive interventions, and ensuring access to user-friendly nets
A personalized 14-3-3 disease-targeting workflow yields repositioning drug candidates
Authors: Larasati Yonika , Solis Gonzalo , Koval Alexey , Korff Christian , Katanaev Vladimir 
Published: January 2025

Abstract

Rare diseases typically evade the application of the standard drug discovery and development pipeline due to their understudied molecular etiology and the small market size. Here, we report a rare disease-directed workflow that rapidly studies the molecular features of the disorder, establishes a high-throughput screening (HTS) platform, and conducts an HTS of thousands of approved drugs to identify and validate repositioning drug candidates. Applied to the pediatric neurological disorder caused by de novo mutations in YWHAG, the gene encoding the scaffolding protein 14-3-3γ, this workflow discovers nuclear relocalization and a severe drop in 14-3-3γ binding to its phosphorylated protein partners as the key molecular features of the pathogenic hotspot YWHAG mutations. We further established a robust in vitro HTS platform and screened ca. 3000 approved drugs to identify the repositioning drug candidates that restore the deficient 14-3-3γ-phosphotarget interactions. Our workflow can be applied to other 14-3-3-related disorders and upscaled for many other rare diseases.
The negative association between C-reactive protein-albumin-lymphocyte (CALLY) index and kidney stone: a cross‑sectional study
Authors: Yang Jiaqing , Du Yuanzhuo , Guo Ju 
Published: January 2025

Abstract

Background
The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel composite biomarker that reflects the body's immune response, nutritional state, and inflammatory response. However, no studies have reported the correlation between CALLY and kidney stones. This study aims to determine the correlation between CALLY and kidney stones.
Methods
Data from the 2007-2010 NHANES surveys were analyzed in this cross-sectional study. A weighted multivariable logistic regression model and smooth curve fitting were employed to examine the correlation between CALLY and kidney stones. Subgroup analyses and interaction assessments were subsequently performed to confirm the robustness of the results.
Results
Among 10,938 participants aged 18 years and older, 9.14% were diagnosed with kidney stones. The results demonstrated a notable inverse relationship between elevated CALLY and the prevalence of kidney stones. Specifically, after performing a natural logarithmic transformation of the CALLY index, the adjusted model showed that with each one-unit rise in lnCALLY, the risk of kidney stones decreased by 21.5% (OR = 0.785; 95% CI: 0.643-0.959; P = 0.01756). Subgroup analyses confirmed the consistency of this relationship across all cohorts, unaffected by stratifying variables. Curve fitting and threshold effect analysis revealed a U-shaped association between CALLY and the risk of kidney stones, with the inflection point at -0.48, showing a significant P-value (< 0.001).
Conclusion
This study identifies a negative correlation between CALLY and the prevalence of kidney stones, characterized by a U-shaped curve. These results indicate the potential of CALLY as a valuable mark for identifying kidney stones.
Epidemiological insights into HIV Prevalence and its Transmission pattern in Mizo tribal population of North East, India
Authors: Khawlhring Lalnunthari , Lalrinpuia Benjamin , Lalngaihzuali Rebecca , Laldinmawii Gracy , Ralte Lalengkimi , Lalnuntluangi Christina , Chawngthu Richard L. , Ralte Jane , Zothanzama John , Kumar Nachimuthu Senthil , Lalthafeli Nalida , Roy Swagnik 
Published: January 2025

Abstract

Background: Mizoram has the highest incidence of Human immunodeficiency virus (HIV) infection in India. India is having world’s third largest population of HIV seropositive and remains a public health problem.
Methods: This study is based on a cross-sectional analysis of HIV surveillance data collected at ART Plus Centre, Civil Hospital Aizawl, Mizoram. The statistical analysis was performed in SPSS® Statistics (V 27.0).
Results: The gender distribution in this study is dominated by men, and the heterosexual contact is the leading mode of HIV transmission. Mizoram reported the highest national rates of HIV prevalence among FSWs and IDUs. ART adherence is better among females than male, and adherence rates are higher in older age groups than in younger ones. ART coverage is still high among elderly persons, despite their low HIV prevalence.
Conclusions: The data shows that a significant proportion of individuals diagnosed with HIV in Mizoram are receiving ART. These patterns suggest that younger population are particularly vulnerable to HIV with poor adherence to ART, possibly due to social stigma, fear of discrimination, or lack of support systems.
Optimising Green Space Locations in Mzuzu City, Malawi: Integration of GIS Multi-Criteria Analysis and Analytical Hierarchy Process
Authors: Bakolo Charles , Chilonga Davie , Chinkaka Emmanuel , Nazombe Kennedy 
Published: January 2025

Abstract

Urban green spaces serve as critical infrastructure for sustainable cities, yet their strategic implementation remains challenging, particularly in developing regions. This study develops a spatial decision support framework for optimal green space allocation in Mzuzu City, Malawi, employing an integrated approach of Geographic Information Systems (GIS), Multi-Criteria Analysis, and Analytical Hierarchy Process. Eight environmental and socio-spatial parameters were analysed: population density, road network proximity, topographic gradient, elevation, vegetation indices, land use patterns, hydrological features, and nitrogen dioxide concentrations. The results indicate that the study area's 6.97% (1,099.65 ha) demonstrates high suitability for green space interventions, while 26.48% (4,178.68 ha) is deemed unsuitable. Population density emerged as the primary determinant, with a weight coefficient of 0.379. Spatial analysis revealed concentrated zones of high suitability in Mchengautuwa West, central-western Nkholongo/Lupaso, Masasa East, and eastern Kaning'ina, contrasting with limited opportunities in Zolozolo East and Msongwe. This research provides a replicable methodology for evidence-based urban greening initiatives in sub-Saharan African cities, contributing to equitable environmental planning and sustainable urban development.
Space and move-optimal arbitrary pattern formation on infinite rectangular grid by oblivious robot swarm
Authors: Sharma Avisek , Ghosh Satakshi , Goswami Pritam , Sau Buddhadeb 
Published: January 2025

Abstract

Arbitrary Pattern Formation (APF) is a fundamental coordination problem in swarm robotics. It requires a set of autonomous robots (mobile computing units) to form an arbitrary pattern (given as input) starting from any initial pattern. This problem has been extensively investigated in continuous and discrete scenarios, with this study focusing on the discrete variant. A set of robots is placed on the nodes of an infinite rectangular grid graph embedded in the euclidean plane. The movements of each robot is restricted to one of the four neighboring grid nodes from its current position. The robots are autonomous, anonymous, identical, and homogeneous, and operate Look-Compute-Move cycles. In this work, we adopt the classical OBLOT robot model, meaning the robots have no persistent memory or explicit communication methods, yet they possess full and unobstructed visibility. This work proposes an algorithm that solves the APF problem in a fully asynchronous scheduler assuming the initial configuration is asymmetric. The considered performance measures of the algorithm are space and number of moves required for the robots. The algorithm is asymptotically move-optimal. Here, we provide a definition of space complexity that takes the visibility issue into consideration. We observe an obvious lower bound D of the space complexity and show that the proposed algorithm has the space complexity D+4. On comparing with previous related works, we show that this is the first proposed algorithm considering OBLOT robot model that is asymptotically move-optimal and has the least space complexity which is almost optimal.
Modeling household's willingness to pay for sustainable rural drinking water supply using hand-pumped boreholes: a bivariate probit analysis in Chilga District, Northwestern Ethiopia
Authors: Nega Yitayew Malede , Taw Tefera Berihun , Mesele Marelign Adugna , Abebe Mekashaw Tareke 
Published: January 2025

ABSTRACT
Access to safe drinking water remains a critical issue in rural areas of developing countries, including Ethiopia, where many communities rely on unimproved sources. This study assesses households’ willingness to pay (WTP) for improved drinking water services in rural Chilga District, Northwestern Ethiopia, focusing on hand-pumped boreholes as a sustainable solution. Using a contingent valuation method (CVM) with a double-bounded dichotomous choice format and a bivariate probit model, the study identifies key factors influencing WTP. Results reveal that female-headed households are more supportive of water improvement projects, while older respondents and those with higher perceived water quality are less likely to pay. Education significantly increases WTP, and households spending more time collecting water are more inclined to pay for improvements. Marginal effects of income on WTP suggest the need for flexible pricing models. The study underscores the need for targeted interventions, educational campaigns, and flexible bidding strategies to enhance community engagement and ensure equitable access to improved water services.
SQSTM1/P62 Mediates the Effects of CPNE3 on the Epithelialmesenchymal Transition and Migratory Inhibition of Lung
Adenocarcinoma Cells
Authors: Li Yanping , Li You , Xu Liming , Yang Guangming , Zhou Huansi , Jin Mingjing , Yu Kai , Lu Chunhua 
Published: January 2025

Introduction:
Copine-3 (CPNE3) is a conservative calcium-dependent phospholipid-binding protein belonging to the copines protein family. CPNE3 has been implicated in the development and progression of several diseases, including cancer

Method:
Herein, we investigated the molecular mechanisms through which CPNE3 regulates the migration of lung adenocarcinoma (LUAD) cells in vitro. Western blotting and
immunohistochemical assays showed that CPNE3 is widely distributed in LUAD tissues
and cell lines and that CPNE3 downregulation promotes the migration of human LUAD
A549 cells.

Results:
Stable isotope labelling with amino acids in cell culture, which is a quantitative
proteomics approach coupled with bioinformatic analyses, revealed that CPNE3 regulates SQSTM1/p62 and vimentin expression, indicating that CPNE3 may mediate epithelial-mesenchymal transition (EMT). CPNE3 silencing by siRNA upregulated vimentin
levels but downregulated E-cadherin levels in the A549 cells.

Conclusion:
Furthermore, SQSTM1/p62 knockdown enhanced migratory ability and
EMT progression in CPNE3-silenced A549 cells. Overall, CPNE3 knockdown was
found to promote EMT by inhibiting SQSTM1/p62 signalling and facilitating cell migration. Our findings highlight the role of CPNE3 as a tumour suppressor, providing deeper
insights into its carcinogenic roles in LUAD.

conclusion:
Overall, CPNE3 knockdown was found to promote EMT by inhibiting SQSTM1/p62 signalling and facilitating cell migration.

other:
Our findings highlight the role of CPNE3 as a tumour suppressor, providing deeper insights into its carcinogenic roles in LUAD.
Molecular Insights into RNA Modifications and their Role in Shaping Immune Responses and Tumor Microenvironments
Authors: Ali Ashiq , Ajmal Tehreem , Khatoon Aisha , Akbar Kaynaat , Irshad Urooj , Murtaza Bilal , ji Ziyi , Ali Abdullah , Tanveer Qaisar , Su Zhongjing 
Published: January 2025

Abstract:
RNA modifications play crucial roles in immune system development and function,
with dynamic changes essential for diverse cellular processes. Innovative profiling technologies
are invaluable for understanding the significance of these modifications in immune cells, both in
healthy and diseased states. This review explores the utility of such technologies in uncovering the
functions of RNA modifications and their impact on immune responses. Additionally, it delves into
the mechanisms through which aberrant RNA modifications influence the tumor microenvironments
immune milieu. Despite significant progress, several outstanding research questions remain,
highlighting the need for further investigation into the molecular mechanisms underlying
RNA modification's effects on immune function in various contexts.
Synthesis of Some Thiazolyl and Oxazolyl Quinazoline Derivatives as Potential Anti-Microbial Agents
Authors: Sharma Krishana Kumar , Kumar Gandharve , Devi Shoma , Kumar Gajendra 
Published: January 2025

Introduction:
Quinazoline holds significant importance in pharmaceutical chemistry, which is included in a range of drugs, clinical contenders, and bioactive compounds. N-contain-ing heterocyclic compounds of quinazoline have a wide and distinct range of biopharmaceutical activities.

Methods:
A series of newly synthesized heterocyclic compounds, namely, N-(4-substituted ben-zylidene)-2-(2-aminothiazol-4-yl)-6-methylquinazolin-3(4H)-amines (3a’-3e’) and N-(4-substi-tuted benzylidene)-2-(2-aminooxazol-4-yl)-6-methylquinazolin-3(4H)-amines (3a-3e), were synthesized starting from 6-methylquinazolin-3(4H)-amine and 4-substituted benzaldehyde and their antibacterial and antifungal properties were evaluated. Moreover, they were compared with the well-known drugs Imipenem (as an antibacterial agent) and Miconazole (as an antifungal).

Results:
Compound 3c' exhibited higher potential activity compared to newly synthesized other compounds and standard drugs when tested against the microorganism.

Conclusion:
The structure of substances was determined through elemental analysis (C.H.N.) and various spectroscopic technique (1H NMR, 13C NMR, IR, and GCMS).
Synthesis, Molecular Docking, Antimicrobial, and Antioxidant Evaluation
of Novel Dithiazole and Thiazole Derivatives
Authors: Khidre Rizk E. , Sabry Eman , A. Sediek Ashraf , F. El-Sayed Ahmed 
Published: January 2025

Introduction:
An efficient procedure was reported for the synthesis of novel
hybrid dithiazoles 7 and thiazoles 15, in good yields, by applying hydrazonyl chlorides 4
with thiocarbohydrazone derivatives 3 and 12

Methods:
The thiazole derivatives were evaluated for their antimicrobial and antioxidant
activities.

Results:
According to the results, thiazoles revealed marked potency as antimicrobial and
antioxidant agents. Thus, 7a's DPPH radical scavenging activity was excellent
(38.19±0.33 and 14.37±0.4) at concentrations of 2.0 and 1.0 mg/mL, respectively. In addition, compound 3 exhibited activity against all bacterial strains tested, as evidenced by inhibition zones measuring that ranged from 8.5±0.43 mm for E. faecalis to 16.5±0.43 mm
for S. mutans.

Conclusion:
The MIC results showed that compound 3 was effective against E. coli, S.
aureus, E. faecalis, P. aeruginosa, and S. mutans at concentrations of 1.0, 1.0, 2.0, 1.0,
and 1.0 mg/mL, respectively. Furthermore, molecular docking has shown lower binding
energy with different types of interactions at the active sites of Dihydropteroate synthase,
Sortase A, LasR, and penicillin-binding protein pockets, indicating that these compounds
could inhibit the enzyme and cause promising antimicrobial effects.

other:
Non
Green Synthesis of Silver Nanoparticles Using Citrullus Colocynthis and Their Inhibitory Effect on the Pathogenic Fungus Scopulariopsis
alboflavescens,”
Authors: Fahmid Shagufta , Jabeen Rukhsana , Maher Saima , Khan Noureen , Batool Fakhra , Urooj Rabail , Imran Muhammad , Naheed Suad , Mehsud Saifullah , Gojayev Anar , Khan Ajmal , Al-Harrasi Ahmed 
Published: January 2025

Introduction:
This work aims to develop an eco-friendly, plant-based synthesis of
silver nanoparticles using Citrullus colocynthis to combat Scopulariopsis alboflavescens. The
approach addresses the need for alternative antifungal treatments and reduces the environmental
impact of conventional methods. It offers a sustainable solution by utilizing the plant’s medicinal
properties in nanotechnology applications.

Method:
Biomimetic synthesis of silver nanoparticles (AgNPs) was prepared by seed, fruit pulp
crude methanolic extract of a medicinal plant Citrullus colocynthis (Linn.) Schrad exhibited the
potential effect to inhibit the growth of the fungus (Scopulariopsis alboflavescens) isolated from
the Juniper tree from Ziarat, Pakistan. The shape, size, specific surface area, charge, and composition
of the silver nanoparticles were studied by UV-visible spectroscopy, infra-red spectroscopy,
x-ray diffraction technique, and atomic force microscopy.

Result:
UV-visible spectrum of AgNPs displayed the surface plasmon resonance (SPR) peak at
(427nm), and Fourier transform infra-red (FTIR) spectrum revealed the possible presence of
polyphenols and alkaloids involved in the synthesis, capping, and stabilizing of AgNPs. Furthermore,
X-ray diffraction (XRD) analysis showed face centered cubic (FCC) shape of AgNPs.
Atomic force microscopic (AFM) analysis showed poly dispersion of AgNPs with a size of
28.8nm. The AgNPs exhibited a significant inhibitory zone of 22.5 mm against Scopulariopsis
alboflavescens as compared to the standard with an inhibition zone of 7.5 mm at 1000 ppm, the
biosynthesized AgNPs might be an effective strategy to control these pathogenic fungi and combat
fungal diseases.

Conclusion:
The findings focus on the efficiency of Cc-AgNPs against S. alboflavescens of
plant-pathogenic fungus and support to develop new and more active therapeutic substitutes for
fungus diseases.