bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of pre-operative and post-operative radiotherapy in patients with localized myxoid liposarcoma
Authors: Masunaga Tomoya , Tsukamoto Shinji , Honoki Kanya , Fujii Hiromasa , Kido Akira , Akahane Manabu , Tanaka Yasuhito , Mavrogenis Andreas F , Errani Costantino , Kawai Akira 
Published: October 2023

Abstract

Background
Myxoid liposarcoma is more radiosensitive than other soft tissue sarcomas, and radiotherapy has been reported to reduce tumour size. This study was performed to compare the rates of local recurrence, survival and wound complications between pre- and post-operative radiotherapy for localized myxoid liposarcoma.

Methods
From the Japanese Nationwide Bone and Soft Tissue Tumor Registry database, 200 patients with localized myxoid liposarcoma who received pre- (range, 30–56 Gy) or post-operative (range, 45–70 Gy) radiotherapy and surgery were included in this retrospective study. Propensity score matching was used to adjust for background differences between patients who received pre- and post-operative radiotherapy.

Results
Local recurrence occurred in five (5.0%) and nine (9.0%) patients in the pre- and post-operative radiotherapy groups, respectively (both n = 100). The median follow-up time from diagnosis was 40.5 months (IQR, 26.3–74). Univariate analysis showed a similar risk of local recurrence between the pre- and post-operative radiotherapy groups (5-year local recurrence-free survival 94.9% [95% CI 87.0–98.1] vs. 89.0% [95% CI 79.6–94.3]; P = 0.167). Disease-specific survival was similar between the pre- and post-operative radiotherapy groups (5-year disease-specific survival 88.1% [95% CI 75.5–94.6] vs. 88.4% [95% CI 77.3–94.5]; P = 0.900). The incidence of wound complications was similar between the pre- and post-operative radiotherapy groups (7.0% vs. 12.0%; P = 0.228).

Conclusions
There was no difference in local recurrence, survival or incidence of wound complications between pre- and post-operative radiotherapy for localized myxoid liposarcoma. Therefore, pre-operative radiotherapy for myxoid liposarcoma provides clinical results equivalent to post-operative radiotherapy.
Oral Reading Traditions and Scriptural Hermeneutics: The Exegetical Significance of the Pausal Systems in the Hebrew Bible and the Qurʾān
Authors: Moqbel Tareq 
Published: October 2023

Abstract
The oral reading traditions of the Hebrew Bible and the Qurʾān have a number of affinities. Recent literature shows that these parallels include orthoepic features, the pluriformity of the oral reading traditions, as well as the representation of non-standard oral traditions in written form. The present article takes this comparative effort one step forward. It explores how pauses influence the exegesis of the Hebrew Bible and the Qurʾān. That is, it examines the impact of the Masoretic pausal accent signs and the pausal suggestions in the Quranic waqf and ibtidāʾ (pausing and beginning) literature on exegesis. Examining several case studies, the article points out parallels in the ways both reading traditions employ pauses in exegesis. Without denying the differences between the two systems, some of which are highlighted in the article, it is found that both seem to operate in conceptually similar ways.
Experimental branching fractions, transition probabilities, and oscillator strengths of La i
Authors: Shang Xue , Zhou Chunxiao 
Published: October 2023

ABSTRACT
Experimental branching fractions of 65 lines in La i were measured based on grating spectroscopy of a lanthanum hollow cathode lamp. Combining these branching fractions with previous energy lifetimes measured using time-resolved laser-induced fluorescence (TR-LIF) spectroscopy, absolute transition probabilities, and oscillator strengths were determined for 34 lines belonging to transitions 4f5d6s–5d6s2, 4f5d6s–5d3, 5d26p–5d6s2, 5d27p–5d26s, and for 31 lines associated with uncertain configurations due to dramatic configuration interaction mixings. These fundamental atomic data will help make atomic models more realistic and provide useful parameters for future astrophysical spectral analysis.
Study of X-ray spectral and timing properties of astronomical sources using low-cost stratospheric balloons
Authors: Sikdar Rupnath , Chakrabarti Sandip K , Bhowmick Debashis 
Published: October 2023

ABSTRACTAstronomical objects, such as the Sun, accreting matter around black holes, neutron stars, white dwarfs, etc. are known to emit X-rays and gamma-rays. Some of these sources, such as highly magnetized neutron stars, show periodic pulsations. Even accreting matter around black holes and neutron stars shows timing properties including quasi-periodic oscillations. In this paper, we use the data of low-cost, lightweight, high-altitude (∼42 km) small, stratospheric balloon-borne missions of the Indian Centre for Space Physics. We measure the intensity of the secondary cosmic rays, the radiation fluxes, and the spectra of persistent X-ray sources or transient events such as solar flares and gamma-ray bursts, apart from routine weather parameters. In this study, we present the source detection method without an onboard pointing system and the temporal and spectral behaviour of the quiet Sun. We also analyse the data containing Crab in the field of view to find the pulsation of the Crab pulsar. During the analysis of the source detection and spectrum of the solar X-rays, we calculate the detector’s background radiation (mainly secondary cosmic rays) using physical assumptions and also take care of the atmospheric absorption effects. Finally, we show the source detection processes for the strong sources such as the Sun, Crab, and Cyg X-1, obtaining the quiet Sun’s spectrum. Among the interesting timing properties, we present the result for the Crab pulsar and find the well-known ∼33 Hz pulsations whenever our instrument pointed to the Crab.
Evolutionary tracks of massive stars with different rotation and metallicity in neutrino H–R diagram
Authors: Wang Hao , Zhu Chunhua , Liu Helei , Guo Sufen , Lü Guoliang 
Published: October 2023

ABSTRACT
Neutrino losses play a crucial role in the evolution of massive stars. We study the neutrino luminosity of stars ranging from 20 to 90 $\rm M_{\odot }$ from Zero Age Main Sequence to Fe Core Collapse (FeCC) with different rotation and metallicity in a neutrino Hertzsprung–Russell diagram. In our simulations, we consider $\rm \omega /\omega _{crit}= 0$ and 0.7 to represent non-rotation and high rotation, respectively, and set the metallicities to 0.014, 0.001, and 0.0001. During hydrogen burning stages, neutrino luminosity primarily originates from CNO cycle, and increases with higher stellar mass while decreasing with increasing metallicity. For the high metallicity models (Z = 0.014) during the helium burning stage, the reduction of the hydrogen envelope caused by a larger mass loss rate leads to a gradual decrease in neutrino luminosity. The rapid rotation results in extra mixing inside massive stars, which increases the neutrino luminosity during main sequence, while decreases the neutrino luminosity during helium burning phase. Simultaneously, the rapid rotation also increases CO core mass, which enhances the neutrino luminosity during C and O burning phase. We also investigate the effect of neutrino magnetic moment (NMM) on the massive stars. We find that the energy loss caused by the NMM does not have effects on the evolutionary destiny of massive stars, and it does not significant change the compactness at the time of FeCC.
The precursor structure in relativistic shocks
Authors: Skuratovsky Barel , Lyubarsky Yuri , Piran Tsvi 
Published: October 2023

ABSTRACT
We present a common unifying macroscopic framework for precursors in relativistic shock waves. These precursors transfer energy and momentum from the hot downstream to the cold upstream, modifying the shock structure. It was shown that in a steady state, there is a maximal fraction of the downstream energy flux that the precursor can carry. We show here that at this critical value, the shock disappears, and the flow passes through a sonic point. This behaviour resembles the classical Newtonian Rayleigh flow problem. At the critical value, the transition is unstable as perturbations in the upstream accumulate at the sonic point. Thus, if such a point is reached, the shock structure is drastically modified, and the flow becomes turbulent.
Antifocal Anaphoras in Hip-Hop Vocals
Authors: Ohriner Mitchell 
Published: October 2023

Abstract
This article examines the pitch content of the delivery of anaphoric lyrics in hip-hop. Anaphoric lyrics consist of lines with a reiterated beginning and a novel ending. Because new information is presented at the ends of lines, the “linguistic focus” of the line is at the end. Therefore, from the standpoint of intonational phonetics, pitch height would tend to rise to highlight the new information. However, from the standpoint of hip-hop delivery, lines tend to descend toward the end. Using a corpus approach, I document a general tendency toward “focally consistent” delivery in which pitch height supports new information. Then, I explore the afforded meanings of “antifocal” delivery—delivery in which the repeated text is pitched higher—in examples from B-Real, the poet Najee Omar, and Kendrick Lamar. I hope that these examples will attract other scholars to view vocal performances simultaneously through lenses of intonational phonology and music analysis and, further, that correspondences between pitch contours and principles of phonology might prove useful as singing, reciting, and rapping increasingly coexist under the banner of “hip-hop.”
Histone Variant H3.3 Controls Arabidopsis Fertility by Regulating Male Gamete Development
Authors: Liu Kunpeng , Yin Chunmei , Ye Wenjing , Ma Min , Wang Yuanda , Wang Pan , Fang Yuda 
Published: October 2023

Abstract
Reprograming of chromatin structures and changes in gene expression are critical for plant male gamete development, and epigenetic marks play an important role in these processes. Histone variant H3.3 is abundant in euchromatin and is largely associated with transcriptional activation. The precise function of H3.3 in gamete development remains unclear in plants. Here, we report that H3.3 is abundantly expressed in Arabidopsis anthers and its knockout mutant h3.3–1 is sterile due to male sterility. Transcriptome analysis of young inflorescence has identified 2348 genes downregulated in h3.3–1 mutant, among which 1087 target genes are directly bound by H3.3, especially at their 3ʹ ends. As a group, this set of H3.3 targets is enriched in the reproduction-associated processes including male gamete generation, pollen sperm cell differentiation and pollen tube growth. The function of H3.3 in male gamete development is dependent on the Anti-Silencing Factor 1A/1B (ASF1A/1B)-Histone regulator A (HIRA)-mediated pathway. Our results suggest that ASF1A/1B-HIRA-mediated H3.3 deposition at its direct targets for transcription activation forms the regulatory networks responsible for male gamete development.
The Therapeutic Potential of Targeting Ferroptosis in the Treatment of Mitochondrial Cardiomyopathies and Heart Failure
Authors: Cantrell Aubrey C. , Zeng Heng , Chen Jian-Xiong 
Published: October 2023

Abstract:
Ferroptosis is a form of iron-regulated cell death implicated in a wide array of diseases, including heart failure, hypertension, and numerous cardiomyopathies. In addition, mitochondrial dysfunction has been associated with several of these same disease states. However, the role of the mitochondrion in ferroptotic cell death remains debated. As a major regulator of cellular iron levels, the mitochondria may very well play a crucial role in the mechanisms behind ferroptosis, but at this point, this has not been adequately defined. Emerging evidence from our laboratory and others indicates a critical role of mitochondrial Sirtuin 3, a deacetylase linked with longevity and protection against numerous conditions, in the prevention of cardiovascular diseases. Here, we provide a brief overview of the potential roles of Sirtuin 3 in mitochondrial iron homeostasis and its contribution to the mitochondrial cardiomyopathy of Friedreich's ataxia and diabetic cardiomyopathy. We also discuss the current knowledge of the involvement of ferroptosis and the mitochondria in these and other cardiovascular disease states, including doxorubicin-induced cardiomyopathy, and provide insight into areas requiring further investigation.
Eye and Orbital Anatomy in Metopic Synostosis
Authors: Gaillard Linda , Puppels Anna E. , Dremmen Marjolein H.G. , Loudon Sjoukje E. , Mathijssen Irene M.J. 
Published: October 2023

Background:
Metopic synostosis patients have a high prevalence of orthoptic anomalies, including hyperopia, astigmatism, and amblyopia. We hypothesized altered orbital anatomy contributes to suboptimal visual outcomes by adversely affecting eye anatomy and growth from early life onward. Therefore, we aimed to investigate eye and orbital anatomy in metopic synostosis.

Methods:
We conducted a retrospective study in nonsyndromic metopic synostosis patients (n = 134, median age 0.43 years [IQR 0.45]) with nonsyndromic sagittal synostosis patients (n = 134, median age 0.27 years [IQR 0.23]) as controls. Primary analyses focused on eye dimensions (axial length, width, and globe height) and orbital dimensions, correcting for sex and age. Measurements were obtained from preoperative computed tomography scans.

Results:
Axial length and width in metopic synostosis patients did not differ from sagittal synostosis patients, but globe height was significantly smaller (P = 0.0002). Lateral wall interorbital length, lateral orbital wall length, anterior medial interorbital length, and maximal medial interorbital length were significantly smaller, and anterior vertical orbital height and maximal vertical orbital height were significantly larger (P < 0.001). The central orbital axis and interorbital angle were significantly narrower, and medial-to-lateral orbital wall angle was wider (P < 0.001).

Conclusions:
Metopic synostosis patients have more shallow, wider, and higher orbits. Eye dimensions are similar in sagittal synostosis patients, although globe height was smaller. Altered orbital and eye dimensions in metopic synostosis probably have a causal relation with an unknown order of development. How these dimensions relate to future orthoptic anomalies (eg, refractive error) needs further investigation.
ZNT1 and Zn2+ control TLR4 and PD-L1 endocytosis in macrophages to improve chemotherapy efficacy against liver tumor
Authors: Yang Dan , Tian Taikun , Li Xiaojing , Zhang Baokai , Qi Linlin , Zhang Fang , Han Mingshun , Wang Shuang , Xiao Jun , Gou Yingying , Zhang Raorao , Liu Qiaojie , Su Sheng , Liu Jiahui , Huang Xiaowu , Gao Qiang , Hui Lijian , Tang Huiru , Chen Yuncong , Wang Hongyan , Wei Bin 
Published: October 2023

Background and Aims:
HCC is closely associated with inflammation and immune modulation, and combined chemotherapy with other strategies is under extensive investigation to achieve better efficacy. HCC is accompanied by zinc (Zn) deficiency. This study aims to understand how Zn could affect macrophage function and its application for HCC therapy.

Approach and Results:
Zn2+ and the Zn transporter 1 (ZNT1, solute carrier family 30 member 1) were markedly reduced in intrahepatic macrophages from patients with HCC and from mouse liver tumors. Lower ZNT1 expression was associated with higher IL-6 production and shorter survival time in patients with HCC. Critically, ZNT1 regulated endosomal Zn2+ levels for endocytosis of toll-like receptor 4 and programmed cell death ligand 1, thereby decreasing macrophage-induced inflammation and immunosuppression to protect from liver tumors. Myeloid-specific deletion of ZNT1 in mice increased chronic inflammation, liver fibrosis, tumor numbers, and size. Notably, Zn supplementation could reduce inflammation and surface programmed cell death ligand 1 expression in macrophages with the increased CD8+ T cell cytotoxicity, which synergized the antitumor efficacy of Sorafenib/Lenvatinib.

Conclusions:
Our study proposes a new concept that ZNT1 and Zn regulate endosome endocytosis to maintain surface receptors, and Zn supplements might be synergized with chemotherapy to treat inflammation-associated tumors, especially those containing programmed cell death ligand 1+ myeloid cells.
Early adoption of laparoscopic liver surgery in Poland: A national retrospective cohort study
Authors: Hołówko Wacław , Serednicki Wojciech , Bartkowiak Mateusz , Wysocki Michał , Domurat Marian , Mielko Jerzy , Pierściński Stanisław , Hogendorf Piotr , Masior Łukasz , Kalinowski Piotr , Wierdak Mateusz , Frączek Mariusz , Tarasik Aleksander , Wróblewski Tadeusz , Budzyński Andrzej , Pędziwiatr Michał , Grąt Michał 
Published: October 2023

Background:
The need for safe and efficient dissemination of minimally invasive approach in liver surgery is among the current challenges for hepatobiliary surgeons. After the stage of innovators and pioneers, the following countries should adopt a laparoscopic approach. The aim of this study was to assess the national experience and trend in implementing laparoscopic liver resection (LLR) in Poland.

Materials and Methods:
A national registry of LLR performed in Poland was established in June 2020. All LLR cases performed before were included retrospectively, followed by prospectively collected new cases. Baseline characteristics, preoperative and intraoperative data, short-term results and long-term follow-up were recorded.

Results:
Since 2010 up to the end of 2022 there were 718 LLRs performed in Poland. The national rate of laparoscopic approach has gradually increased since 2017 (P<0.001), reaching the rate of 11.7% in 2022. There were 443 (61.7%), 107 (14.9%) and 168 (23.4%) LLRs performed in accordance to increasing grades of difficulty. The move towards more demanding cases had an increasing trend over the years (P<0.001). Total intraoperative adverse event and postoperative severe complications rates were estimated for 13.5% (n=97) and 6.7% (n=48), respectively. 30-day reoperation, readmission and postoperative mortality rates were 3.6% (n=26), 2.8% (n=20) and 0.8% (n=6), respectively. While the R0 resection margin was assessed in 643 (89.6%) cases, the total textbook outcomes (TO) were achieved in 525 (74.5%) cases. Overcoming the learning curve of 60 LLRs, resulted in an increasing TO rate from 72.3% to 80.6% (P=0.024).

Conclusion:
It is the first national analysis of a laparoscopic approach in liver surgery in Poland. An increasing trend of minimizing invasiveness in liver resection has been observed. Responsible selection of cases in accordance with difficulty may provide results within global benchmark values and textbook outcomes already during the learning curve.
Cheminformatics analysis of multi-target structure-activity landscape of environmental chemicals binding to human endocrine receptors
Authors: Baskaran Shanmuga Priya , Sahoo Ajaya Kumar , Chivukula Nikhil , Kumar Kishan , Samal Areejit 
Published: October 2023

AbstractIn human exposome, environmental chemicals can target, and disrupt different endocrine axes, ultimately leading to several endocrine disorders. Such chemicals, termed endocrine disrupting chemicals (EDCs), can promiscuously bind to different endocrine receptors and lead to varying biological endpoints. Thus, understanding the complexity in molecule-receptor binding of environmental chemicals can aid in the development of robust toxicity predictors. Towards this, the ToxCast project has generated the largest resource on the chemical-receptor activity data for environmental chemicals that were screened across various endocrine receptors. However, the heterogeneity in the multi-target structure-activity landscape of such chemicals is not yet explored. In this study, we systematically curated the chemicals targeting 8 human endocrine receptors, their activity values and biological endpoints from the ToxCast chemical library. We employed dual-activity difference and triple-activity difference maps to identify single-, dual-, and triple-target cliffs across different target combinations. We annotated the identified activity cliffs through matched molecular pair (MMP) based approach, and observed that a small fraction of activity cliffs form MMPs. Further, we structurally classified the activity cliffs and observed that R-group cliffs form the highest fraction among the cliffs identified in various target combinations. Finally, we leveraged the mechanism of action (MOA) annotations to analyze structure-mechanism relationships, identified strong MOA-cliffs and weak MOA-cliffs, for each of the 8 endocrine receptors. Overall, insights from this first study analyzing the structure-activity landscape of environmental chemicals targeting multiple human endocrine receptors, will likely contribute towards the development of better toxicity prediction models for characterizing the human chemical exposome.
A wave of minorde novoDNA methylation initiates in mouse 8-cell embryos and co-regulates imprinted X- chromosome inactivation with H3K27me3
Authors: Yue Yuan , Fu Wei , Yang Qianying , Zhang Chao , Wang Wenjuan , Chu Meiqiang , Lyu Qingji , Tang Yawen , Cui Jian , Wang Xiaodong , Zhang Zhenni , Tian Jianhui , An Lei 
Published: October 2023

ABSTRACTDNA methylation is extensively reprogrammed during early stage of mammalian development and is essential for normal embryogenesis. It is well established that mouse embryos acquire genome-wide DNA methylation during implantation, referred to asde novoDNA methylation, from globally hypomethylated blastocysts. However, the fact that the mainde novoDNA methyltransferase 3B (DNMT3B) is initially expressed as early as the 8-cell stage, contradicts the current knowledge about timing of initiation ofde novoDNA methylation. Here, we reported that a previously overlooked minor wave ofde novoDNA methylation initially occurs during the transition from the 8-cell to blastocyst stage, before the well-known large-scalede novoDNA methylation during implantation. Functional analyses indicated that minorde novoDNA methylation regulates proliferation, lineage differentiation and metabolic homeostasis of preimplantation embryos, and is critical for embryonic developmental potential and pregnancy outcomes. Furthermore, bioinformatic and functional analyses indicated that minorde novoDNA methylation preferentially occurs on the X chromosome and co-regulates imprinted X-chromosome inactivation via the interaction between DNMT3B and polycomb repressive complexes 2 core components during blastocyst formation. Thus, our study updates the current knowledge of embryonicde novoDNA methylation, thereby providing a novel insight of early embryonic epigenetic reprogramming.Summary statementA minor wave ofde novoDNA methylation has been initiated prior to blastocyst formation, but not during the implantation period, and co-regulates imprinted X-chromosome inactivation.