bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of refractory shock with vitamin B12: A narrative review
Authors: Wedemire Courtney , Samavat Hamed , Newkirk Melanie , Parker Anna 
Published: November 2023

AbstractHigh‐dose vitamin B12 is a potential treatment for patients with vasodilatory shock that is refractory to other therapies. Vasodilatory shock is characterized by low blood pressure and low systemic vascular resistance. Nitric oxide and hydrogen sulfide, two potential targets of high‐dose vitamin B12 given as hydroxocobalamin, facilitate this syndrome. This review explores the relationship between high‐dose vitamin B12 and hemodynamic outcomes in adults with vasodilatory shock and provides an update on the literature since a 2019 review on this topic. A literature search of studies published in the past 5 years was conducted in the CINAHL, PubMed, Cochrane, and EMBASE databases in May 2023. After assessing for eligibility, eight studies met this review's inclusion criteria. Seven of the eight studies reported decreased vasopressor requirements for part or all of the study samples after receiving a hydroxocobalamin infusion. However, not all patients responded to hydroxocobalamin. These findings are limited by patient selection and differences in the timing of vasopressor requirement and blood pressure outcome assessments. The current evidence is promising as to whether vitamin B12, given as a hydroxocobalamin infusion, may improve hemodynamic outcomes in vasodilatory shock, but the evidence is of low quality. The use of hydroxocobalamin to treat refractory, vasodilatory shock remains investigative. Larger randomized controlled trials are required to elucidate the role of vitamin B12 in treating refractory, vasodilatory shock, including in conjunction with other alternative therapies such as methylene blue and corticosteroids.
Mindfulness in ward nurses: A concept analysis
Authors: Feng Xiaoyan , Zhu Hongjun , Cai Ping , Zhang Yingying , Chen Yuhong 
Published: November 2023

AbstractAimMindfulness has been widely used with all kinds of people, such as students, educators or patients. However, there have been no studies explicitly targeting ward nurses. The aim of this study is to explore the concept analysis of mindfulness in ward nurses.DesignA concept analysis.MethodsAn electronic literature search of MEDLINE, Google Scholar, PubMed, Cambridge Online Dictionary and EBSCO on mindfulness was conducted over a ten‐year period of Peer‐reviewed scholarly articles published in English. The Walker and Avant's framework was used for this paper.ResultsEleven articles in total were included in this study. Three attributes of mindfulness in ward nurses were identified as in the present moment, paying attention and being receptive. The consequence of mindfulness in ward nurses lead to positive changes, which included improving well‐being, decreased burnout, anxiety and depression. An exploration of mindfulness in ward nurses was developed. The findings of this paper can be used in ward nurses, research and administration.
In utero/peripartum antiretroviral therapy exposure and mental health outcomes at 8–18 years old: A longitudinal comparative study of children with perinatally acquired HIV, children perinatally HIV exposed but uninfected, and children unexposed uninfected from Uganda
Authors: Coventry Audrey , Sikorskii Alla , Zalwango Sarah K. , Familiar‐Lopez Itziar , Cardino Vanessa N. , Giordani Bruno , Ezeamama Amara E. 
Published: November 2023

AbstractIn utero/peripartum antiretroviral therapy (IPA) exposure type was examined in relationship to mental health symptoms among 577 children with perinatally acquired HIV (CPHIV), children perinatally HIV exposed but uninfected (CHEU), and children HIV unexposed uninfected (CHUU). IPA exposure was categorized for CPHIV and CHEU as none, single‐dose nevirapine with or without zidovudine (sdNVP±AZT), sdNVP+AZT+lamivudine (3TC), or combination antiretroviral therapy (cART). Anxiety and depressive symptoms were reported at baseline, 6‐, and 12‐month follow‐up per behavioral assessment system for children. Multivariable linear mixed models were used to estimate differences (b) with 95% confidence intervals (95% CI) for IPA exposure types versus CHEU without IPA exposure. Depressive and anxiety symptoms were lower in CHUU relative to CHEU and CPHIV but did not differ between CPHIV and CHEU. CHEU with sdNVP±AZT exposure had greater anxiety (b = 0.51, 95% CI: [0.06, 0.96]) and depressive symptoms (b = 0.48, 95% CI: [0.07, 0.89]) than CHEU without IPA exposure. CHEU with sdNVP+AZT+3TC exposure had higher anxiety (b = 0.0.45, 95% CI: [0.03, 0.86]) and depressive symptoms (b = 0.72, 95% CI: [0.27, 1.17]) versus CHEU without IPA exposure. Depressive and anxiety symptoms were not different for CHEU and CPHIV exposed to cART (b = 0.12–0.60, 95% CI: [−0.41, 1.30]) and CHEU and CHUU (b = −0.04 to 0.08, 95% CI: [−0.24, 0.29]) without IPA exposure. Among CHEU, peripartum sdNVP±AZT and sdNVP+AZT+3TC but not cART compared to no IPA exposure was associated with clinically important elevations in anxiety and depressive symptoms. Monitoring of mental health trajectory of HIV‐affected children considering IPA is needed to inform mental health interventions. Patient Contribution: Caregivers and their dependents provided consent for participation and collaborated with study team to identify mutually convenient times for protocol implementation.
Reorganizing heterogeneous information from host–microbe interaction reveals innate associations among samples
Authors: Cui Hongfei 
Published: November 2023

AbstractThe information on host–microbe interactions contained in the operational taxonomic unit (OTU) abundance table can serve as a clue to understanding the biological traits of OTUs and samples. Some studies have inferred the taxonomies or functions of OTUs by constructing co‐occurrence networks, but co‐occurrence networks can only encompass a small fraction of all OTUs due to the high sparsity of the OTU table. There is a lack of studies that intensively explore and use the information on sample‐OTU interactions. This study constructed a sample‐OTU heterogeneous information network and represented the nodes in the network through the heterogeneous graph embedding method to form the OTU space and sample space. Taking advantage of the represented OTU and sample vectors combined with the original OTU abundance information, an Integrated Model of Embedded Taxonomies and Abundance (IMETA) was proposed for predicting sample attributes, such as phenotypes and individual diet habits. Both the OTU space and sample space contain reasonable biological or medical semantic information, and the IMETA using embedded OTU and sample vectors can have stable and good performance in the sample classification tasks. This suggests that the embedding representation based on the sample‐OTU heterogeneous information network can provide more useful information for understanding microbiome samples. This study conducted quantified representations of the biological characteristics within the OTUs and samples, which is a good attempt to increase the utilization rate of information in the OTU abundance table, and it promotes a deeper understanding of the underlying knowledge of human microbiome.
Asymmetric Electrode Design for High‐Area Capacity and High‐Energy Efficiency Hybrid Zn Batteries
Authors: Ma Yanyi , Zhao Zhongxi , Cui Yifan , Yu Jianwen , Tan Peng 
Published: November 2023

AbstractCompared to Zn‐air batteries, by integrating Zn‐transition metal compound reactions and oxygen redox reactions at the cell level, hybrid Zn batteries are proposed to achieve higher energy density and energy efficiency. However, attaining relatively higher energy efficiency relies on controlling the discharge capacity. At high area capacities, the proportion of the high voltage section can be neglected, resulting in a lower energy efficiency similar to that of Zn‐air batteries. Here, a high‐loading integrated electrode with an asymmetric structure and asymmetric wettability is fabricated, which consists of a thick nickel hydroxide (Ni(OH)2) electrode layer with vertical array channels achieving high capacity and high utilization, and a thin NiCo2O4 nanopartical‐decorated N‐doped graphene nanosheets (NiCo2O4/N‐G) catalyst layer with superior oxygen catalytic activity. The asymmetric wettability satisfies the wettability requirements for both Zn‐Ni and Zn‐air reactions. The hybrid Zn battery with the integrated electrode exhibits a remarkable peak power density of 141.9 mW cm−2, superior rate performance with an energy efficiency of 71.4% even at 20 mA cm−2, and exceptional cycling stability maintaining a stable energy efficiency of ≈84% at 2 mA cm−2 over 100 cycles (400 h).
Protective effect of chicory and/or artichoke leaves extracts on carbon tetrachloride and gamma‐irradiation‐induced chronic nephrotoxicity in rats
Authors: Eassawy Mamdouh M. T. , Ismail Amel F. M. 
Published: November 2023

AbstractThe prevalence of chronic kidney disease (CKD) is in progress that causes kidney failure, leading to global problems. This manuscript investigated the nephroprotective effects of chicory (CLE) and/or artichoke (ALE) leaves extracts on carbon tetrachloride (CCl4) and gamma‐irradiation (Rad)‐induced chronic nephrotoxicity in rats. Rats were divided into 10 groups (10 animals/group): group 1: control, groups 2–7 rats were treated with CLE, ALE, CLE/ALE, CCl4, Rad, and CCl4/Rad, respectively. Groups 8 to 10, rats were intoxicated with CCl4/Rad, and treated with CLE, ALE, and CLE/ALE extracts, respectively, for 4 weeks. The data demonstrated that CCl4 administration or Rad exposure induced high levels of urea and creatinine, with low levels of total protein and albumin in the serum. However, high levels of malondialdehyde (MDA), nitric oxide (NO), hydrogen peroxide (H2O2), some pro‐inflammatory markers such as interleukins (IL‐1β, IL‐2, IL‐6), TNF‐α, NF‐κB, the fibrotic marker; TGF‐β1, calcium, and copper, low contents of reduced glutathione (GSH), iron, and zinc, and suppression of the antioxidant enzymes' activity, superoxide dismutase (SOD), and catalase (CAT) were observed. In addition, the Wnt and β‐catenin protein expression ratios were up‐regulated in the kidney tissues of the CCl4, and Rad intoxicated animals. However, the combined treatment CCl4/Rad augmented these measurements. On the other hand, CLE, ALE, and CLE/ALE treatments demonstrated nephroprotection in the kidney tissues of CCl4/Rad intoxicated animals, in the order of CLE/ALE>ALE>CLE by ameliorating the investigated parameters. Kidney tissues' histopathological examinations confirmed these results. In conclusion, CLE and/or ALE demonstrated nephroprotection against CCl4/Rad co‐toxicity mediated by down‐regulation of renal Wnt/β‐catenin protein expressions.
Placenta accreta spectrum conservative management and coagulopathy: case series and systematic review
Authors: Abi Habib P. , Goetzinger K. , Turan O. M. 
Published: November 2023

ABSTRACTObjectiveManagement of placenta accreta spectrum (PAS) with the placenta kept in situ aims to preserve fertility and minimize blood loss. However, this method is associated with a risk of coagulopathy and subsequent bleeding. The aim of this study was to evaluate the occurrence and pathophysiology of coagulopathy in cases of PAS managed conservatively.MethodsWe reviewed our database for cases of PAS in which the placenta was kept in situ. In addition, we performed a systematic review of articles on PAS in which the placenta was left in situ and was complicated by coagulopathy. PubMed was searched for publications between 1980 and 2023. Our eligibility criteria included studies in which no additional interventions were performed other than keeping the placenta entirely in situ, and in which coagulopathy was reported.ResultsAfter screening and selection of full‐text articles, 10 studies were included in the review. A review of our databases yielded a case series of PAS managed conservatively with the placenta kept in situ. When adding our case series to the results of our systematic review, a total of 87 cases were found to have been managed conservatively, with 28 cases of coagulopathy. Of these, the time at which coagulopathy developed was known in 11 cases. The median time at development of coagulopathy was 58 (interquartile range, 50–67) days postpartum.ConclusionsOur findings highlight that conservative management of PAS with the placenta in situ poses a risk of coagulopathy. Keeping the placenta in situ after delivery prolongs the risk factors that are integral to PAS. The pathophysiology behind coagulopathy is comparable with that of concealed placental abruption, due to the disrupted uteroplacental interface and the collection of blood in the placenta. Therefore, the presence of large placental lakes could be an indicator of developing coagulopathy. © 2023 International Society of Ultrasound in Obstetrics and Gynecology.
Can I benefit from laboratory automation? A decision aid for the successful introduction of laboratory automation
Authors: Rupp Nicole , Ries Robert , Wienbruch Rebecca , Zuchner Thole 
Published: November 2023

AbstractThe large volumes of samples to be analysed every day would be impossible to manage without laboratory automation. As laboratory procedures have progressed, so have the tasks of laboratory personnel. With this feature article, we would like to provide (bio)chemical practitioners with little or no knowledge of laboratory automation with a guide to help them decide whether to implement laboratory automation and find a suitable system. Especially in small- and medium-sized laboratories, operating a laboratory system means having bioanalytical knowledge, but also being familiar with the technical aspects. However, time, budget and personnel limitations allow little opportunity for personnel to get into the depths of laboratory automation. This includes not only the operation, but also the decision to purchase an automation system. Hasty investments do not only result in slow or non-existent cost recovery, but also occupy valuable laboratory space. We have structured the article as a decision tree, so readers can selectively read chapters that apply to their individual situation. This flexible approach allows each reader to create a personal reading flow tailored to their specific needs. We tried to address a variety of perspectives on the topic, including people who are either supportive or sceptical of laboratory automation, personnel who want or need to automate specific processes, those who are unsure whether to automate and those who are interested in automation but do not know which areas to prioritize. We also help to make a decision whether to reactivate or discard already existing and unused laboratory equipment.
Towards computational fluid dynamics applications in brewing process
Authors: Jagiełło Kacper , Ludwig Wojciech 
Published: November 2023

AbstractThe popularity of beer and the complexity of its formation call for simulating and optimizing the operations that take place during brewing in order to reduce energy costs, minimize the consumption of raw materials, maximize the use of equipment, and produce a product of the best possible quality. In recent decades, noteworthy progress has been made in understanding the phenomena occurring in various industrial devices thanks to Computational Fluid Dynamics (CFD). This article is a review of previous attempts to use CFD methods to understand and simulate the processes that accompany individual stages of beer production. Additionally, the paper indicates the possible use of CFD methods for processes that have not been modelled yet in the brewing industry.
Interdecadal change in the relationship between the boreal winter North Pacific Oscillation and the following summer El Niño
Authors: Min Qingye , Zhang Renhe 
Published: November 2023

AbstractThe boreal winter North Pacific Oscillation (NPO) has a significant impact on the tropical Pacific large scale air-sea interaction in the following spring and summer. But it is unclear whether the boreal winter NPO is associated with the El Niño development or decaying during following summer. This study confirms the relationship between the winter NPO-like sea level pressure anomalies and following summertime El Niño and reveals an interdecadal change in this relationship. It tends to promote the development of sea surface temperature anomaly in central equatorial Pacific in the following summer when the subtropical lobe of the NPO located west of its average position. But after a significant eastward shift of NPO’s subtropical lobe, it is more conducive to the development of sea surface temperature anomaly in eastern equatorial Pacific. The eastward shift of the NPO’s subtropical lobe altered both the seasonal foortprint mechanism and the trade wind charging mechanism associated with the NPO, thus profoundly influenced the summertime El Niño. The findings in the present study have implications for a better understanding of the relationship between the boreal winter NPO and the El Niño in developing summer.
Valvulotomy of the great saphenous vein in ex situ non-reversed and in situ setting: a multicenter post-market study to assess the safety and efficacy of the AndraValvulotome™”
Authors: Souri Yaser , Liebetrau Dominik , Hyhlik-Dürr Alexander ,   Vascular Investigators, Weigang E. , Kemke J. , Branzan D. , Wilhelmi M. , Classen S. , Pfister K. , Kuhnert M. , Seifert S. , Derwich W. , Stavroulakis K. 
Published: November 2023

Abstract
Purpose
To evaluate the safety and technical success of the AndraValvulotome™ device (Andramed GmbH, Reutlingen, Germany) in patients with peripheral arterial disease (PAD) requiring bypass surgery using the great saphenous vein (GSV) as graft.

Methods
This was a multicenter, post-market observational study conducted in 2021 in 11 German centers. Safety and efficacy data were prospectively collected and analyzed. Primary endpoints were the absence of device-related serious adverse events until 30 ± 7 days follow-up, the clinical efficacy of valvulotomy, which was defined as pulsatile blood flow in the bypass and the number of insufficiently destroyed vein valves. Secondary endpoints were the number of valvulotomy passages, the primary patency rate of the venous bypass (determined by a color-duplex sonography showing a normal blood flow through the bypass and absence of stenosis or occlusion), and the primary technical success defined as the absence of product-specific (serious) adverse events and clinical efficacy.

Results
Fifty-nine patients were enrolled. The mean age of the patients was 71 years (46–91), and 74.6% were males. The vein material used for bypass grafting had a median length of 47.5 cm (range 20–70 cm) with a median diameter of 5.0 mm (range 3–6 mm) and 4.0 mm (range 2–6 mm) in the proximal and distal segments, respectively. The technical success rate was 96.6%. The primary patency rate was 89.9% at 30 days follow-up. The clinical efficacy was rated as very good in 81% of patients, fair in 17%, and poor in 2%. Between 1 and 5 (average 2.9) valvulotome passages were performed. One product-related serious adverse event was recorded (bypass vein dissection).

Conclusion
The AndraValvulotome™ can be considered a safe and effective device to disrupt venous valves during in situ non-reversed bypass surgeries using GSV grafts in patients with PAD.
Palladium nanoclusters as a label to determine GFAP in human serum from donors with stroke by bimodal detection: inductively coupled plasma-mass spectrometry and linear sweep voltammetry
Authors: Rodríguez-Penedo Alejandro , Costa-Rama Estefanía , Fernández Beatriz , García-Cabo Carmen , Benavente Lorena , Calleja Sergio , Fernández-Abedul M. Teresa , Pereiro Rosario 
Published: November 2023

AbstractWater-soluble, stable, and monodisperse palladium nanoclusters (PdNCs) were synthesized using NaBH4 as a reductant and lipoic acid as a ligand. PdNCs, measured by high-resolution transmission electron microscopy, showed a round shape and a diameter of 2.49 ± 0.02 nm. It was found that each PdNC contains 550 Pd atoms on average. These PdNCs offer high amplification as a label of biochemical reactions when inductively coupled plasma-mass spectrometry (ICP-MS) is used as a detector. In addition, PdNCs have catalytic activity on electrochemical reactions, allowing detection by linear sweep voltammetry (LSV). As a proof of applicability, a competitive immunoassay based on PdNC labels was developed for the determination of glial fibrillary acidic protein (GFAP) in human serum, comparing ICP-MS and LSV detection. GFAP is a biomarker for differentiating between patients with ischemic stroke (IS) and hemorrhagic stroke (HS). The limit of detection (LoD), corresponding to IC10 (4-parameter logistic curve), was 0.03 pM of GFAP, both by ICP-MS and LSV, being lower than the 0.31 pM LoD provided by the ELISA commercial kit. Using the error profile method, 0.03 pM and 0.11 pM LoDs were obtained respectively by ICP-MS and LSV: LoD is lower by ICP-MS due to the better precision of the measurements. The analyses of human serum samples from IS, HS, and control (CT) donors using PdNC labels and detection by ICP-MS and LSV were validated with a commercial ELISA kit (for CT donors only ICP-MS provided enough sensitivity). Results point out toward the future use of PdNCs as a label in other immunoprobes for the determination of specific proteins requiring very low LoDs as well as the development of electrochemical decentralized methodologies.
Graphical Abstract
Self-assembled miR-134-5p inhibitor nanoparticles ameliorate experimental bronchopulmonary dysplasia (BPD) via suppressing ferroptosis
Authors: Lan Jiang , Chen Xu , Xu Fengdan , Tao Fangfei , Liu Liyuan , Cheng Rui , Li Ning , Pan Ya 
Published: November 2023

AbstractBronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants with increased levels of reactive oxygen species (ROS) and ferroptosis. Herein, we designed a peptide-based nanoparticle to deliver therapeutic molecules to pulmonary, thereby ameliorating BPD. The BPD-induced damages of lung tissues were detected by H&E and immunohistochemistry staining. Inflammatory cytokines, Fe2+, and ROS levels were quantified by the indicated kits, respectively. The targeting relationship was verified by luciferase reporter assay and pull-down assay. Subsequently, self-assembled miR-134-5p inhibitor nanoparticles with pulmonary epithelial cell-targeting were synthesized. The characteristics were detected by transmission electron microscopy, luminescence imaging, and dynamic light scattering. A significant ferroptosis was observed in the BPD mice. The protein level of GPX4 was decreased significantly compared to the control group. Constantly, miR-134-5p showed positive regulation on ferroptosis by targeting GPX4. The designed nanoparticles were mainly accumulated in the lung region. Besides, it ameliorated experimental bronchopulmonary dysplasia via suppressing ferroptosis, in vivo and in vitro. Our findings provided a miR-134-5p/GPX4 axis in regulating ferroptosis of BPD and prompted the potential of applying the peptide-based nanoparticle to BPD treatment.