bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic Medication for the Treatment of Prurigo Nodularis—A Systematic Review
Authors: McCampbell Lillian E. , Zaino Mallory L. , Ranpariya Manas , Patel Tejesh , Feldman Steven R. 
Published: November 2023

Importance Prurigo nodularis (PN) is a debilitating inflammatory skin disease characterized by red to violaceous pruritic lesions. The goal of therapy is to break the scratch-itch cycle. Treatment varies and often requires a multimodal approach to target both immune and neural mediated aspects of disease. Objectives To review the efficacy of systemic treatment used to treat PN. Evidence review A systematic search of keywords and Medical Subject Headings was performed in Ovid MEDLINE, Embase, Scopus, and ClinicalTrials.gov. The first 200 results of an abbreviated search in Google Scholar were also included. PRISMA guidelines were followed and the review was registered on PROSPERO (CRD42023412012). GRADE criteria were used to assess articles for quality of evidence. Findings The search resulted in 1153 articles; 382 were duplicates, 643 were irrelevant, 19 were not retrieved, 21 were abstract only, and 88 are included in this review. There were 24 studies on dupilumab, 16 on thalidomide, 8 on cyclosporin, 7 on methotrexate, 3 each on lenalidomide and aprepitant, 2 each on alitretinoin, apremilast, baricitinib, gabapentin, intravenous (IV) immunoglobulins, pregabalin, tofacitinib, and 1 each on amitriptyline, azathioprine, butorphanol, isoquercitin, IV dexamethasone-cyclophosphamide/ oral cyclophosphamide, ketotifen, metronidazole, montelukast, nalbuphine, nemolizumab, serolopitant, tacrolimus, and herose derma zima capsule. Conclusions and relevance Dupilumab reduces pruritus and appearance of lesions and is associated with the fewest number of side effects. Thalidomide and pregabalin are also effective, but their long-term use is limited by muscle and nerve pain. Janus Kinase inhibitors may be beneficial, but large population studies are lacking.
Flexural improvement of reinforced concrete beams strengthened with self-prestressing shape memory alloys
Authors: Alkhairo Ahmed , Oukaili Nazar , Al-Mahaidi Riadh 
Published: November 2023

The study reported here aims to investigate the application of shape memory alloys (SMAs) in the form of strips for strengthening cracked reinforced concrete (RC) beams. The study proposes an innovative technique for prestressing RC beams by utilizing the shape recovery property of the alloy. Nine full-scale RC beams with a length of 3.75 m and a cross-section of 200 mm × 300 mm were categorized into three groups based on the steel reinforcement ratio, and tested under static loading. Three RC beams were used as control specimens and the other six were retrofitted with either one layer or two layers of SMA strips. The beams to be strengthened were exposed to an initial applied load before the installation of the SMA strip to simulate the deterioration scenario. SMA strips were retrofitted on the soffits of the deteriorated beams and activated by applying temperature from an external heat source while the temperature-deflection-strain measurements were monitored. Specimens were tested again up to failure to evaluate the strength improvement of the retrofitted specimens. Beams retrofitted with one layer of SMA experienced a deflection recovery up to 2.3 mm upon activation and an additional service load of up to 62%, whereas beams retrofitted with two layers experienced a deflection recovery up to 2.8 mm and an additional service load of up to 95%. In general, the deflection recovery was proportional to the ratio of the total reinforcement ratio after strengthening to the initial reinforcement ratio before strengthening. Therefore, tested specimens with two SMA layers experienced less improvement than specimens with one SMA layer. Finally, the experimental results were evaluated with two analytical methods: ACI method and the non-linear sectional analysis proposed by Oukaili.
Sound insulation performance and modal analysis of asymmetrical insulating laminated glass
Authors: Zhu Xi , Wang Li Juan , Wang Xiao Li , Zheng Yi De , Luo Liang 
Published: November 2023

Windows are commonly the primary way for noise to enter the building environment. Most windows achieve higher sound insulation targets by simply increasing glass thickness or laminate. However, the glass thickness cannot be increased freely due to the window frame’s limitation. This research selects eleven kinds of asymmetric insulating laminated glass (glass + polyvinyl butyral + glass + air + glass) within 27 mm, which are the typical thicknesses of window frames. The three pieces of glass have equal thicknesses. The half-space acoustics method investigated the acoustic properties and modal behavior of the glass with finite thickness. The results show that when PVB or three glass increases simultaneously, and the sound insulation of each glass can be improved by 0.9∼3.4 dB or 3.7∼21.8 dB at first resonant frequencies, respectively. The glass with the best sound insulation is 7 mm glass + 0.76 mm polyvinyl butyral + 7 mm glass + 5 mm air + 7 mm glass (7 + 0.76 + 7 + 5A + 7 for short). Its sound transmission loss (TL) is 38.5 dB from 125 to 4000 Hz and 16.8 dB in the first resonant frequency (200 Hz). In addition, its first resonant frequency is the highest among eleven kinds of glass, and the number of natural frequencies in the low frequency range is only 9. These findings can provide a basis for designing asymmetric insulating laminated glass to improve the low frequency noise reduction effect effectively.
Correlation between 25 (OH) D levels in aqueous humor and the patients with ARC
Authors: Huang Gang , Suo Wen Qi , Du Jian Ying , Zhang Xiong 
Published: November 2023

Objective Age-related cataract (ARC) is an eye disease characterized by lens opacity. This study analyzed the correlation between 25 hydroxyvitamin D [25 (OH) D] levels and Interleukin 6 (IL-6) levels in aqueous humor from the patients with ARC, as well as between 25 (OH) D levels and lens opacity, and explored the effect of 25 (OH) D on the pathogenesis of ARC. Methods A retrospective analysis was performed, which included the clinical data from 120 ARC patients and 40 healthy individuals. They were divided into three groups based on the objective scattering index (OSI): 40 healthy individuals (control group), 84 patients with the early cataract (EC group), and 36 patients with the mature cataract (MC group). An electrochemical luminescence method was used to detect the levels of 25 (OH) D and IL-6 in aqueous humor, the OSI of the eye was measured using a visual quality analysis system. The correlation between the changes in the above indicators and ARC was analyzed. Results The OSI and IL-6 levels in the control group, EC group, and MC group increased sequentially (all p < .001), while the levels of 25 (OH) D showed an opposite trend (all p < .001). Conclusion The decrease in 25 (OH) D levels is related to the occurrence and development of ARC, and the relationship between 25 (OH) D deficiency and the pathological mechanism of ARC needs further research.
Algorithmic benchmark modulation: A novel method to develop success rates for clinical studies
Authors: Willigers Bart JA , Nagarajan Sridevi , Ghiorghui Serban , Darken Patrick , Lennard Simon 
Published: November 2023

Background High-quality decision-making in the pharmaceutical industry requires accurate assessments of the Probability of Technical Success of clinical trials. Failure to do so will lead to lost opportunities for both patients and investors. Pharmaceutical companies employ different methodologies to determine Probability of Technical Success values. Some companies use power and assurance calculations; others prefer to use industry benchmarks with or without the overlay of subjective modulations. At AstraZeneca, both assurance calculations and industry benchmarks are used, and both methods are combined with modulations. Methods AstraZeneca has recently implemented a simple algorithm that allows for modulation of a Probability of Technical Success value. The algorithm is based on a set of multiple-choice questions. These questions cover a comprehensive set of issues that have historically been considered by AstraZeneca when subjective modulations to Probability of Technical Success values were made but do so in a much more structured way. Results A set of 57 phase 3 Probability of Technical Success assessments suggests that AstraZeneca’s historical estimation of Probability of Technical Success has been reasonably accurate. A good correlation between the subjective modulation and the modulation algorithm was found. This latter observation, combined with the finding that historically AstraZeneca has been reasonably accurate in its estimation of Probability of Technical Success, gives confidence in the validity of the novel method. Discussion Although it is too early to demonstrate whether the method has improved the accuracy of company’s Probability of Technical Success assessments, we present our data and analysis here in the hope that it may assist the pharmaceutical industry in addressing this key challenge. This new methodology, developed for pivotal studies, enables AstraZeneca to develop more consistent Probability of Technical Success assessments with less effort and can be used to adjust benchmarks as well as assurance calculations. Conclusion The Probability of Technical Success modulation algorithm addresses several concerns generally associated with assurance calculations or benchmark without modulation: selection biases, situations where little relevant prior data are available and the difficulty to model many factors affecting study outcomes. As opposed to using industry benchmarks, the Probability of Technical Success modulation algorithm allows to accommodate project-specific considerations.
Development of a core outcome set for traumatic brachial plexus injury
Authors: Miller Caroline , Cross Jane , Power Dominic M. , Jerosch-Herold Christina ,   International brachial plexus consensus group, Moore Amy , Shaarani Andrea , Källströmer Anna , Alexander Anne , Hill Bridget , Farrell Carolyne , Wee Catherine , Dy Christopher , Larsen Dorthe Juul , Ng Chye Yew , Romer-Prieto Fernando Xavier , Reilly Fiona , Ivaldo Flavio Caesar , Bourke Grainne , Brown Hazel , Millkvist Helena , Kissow Helen , Holly Janet , Cullen Jaslyn , Sullivan Joel O , Groen Justus , Johnson Kathryn , Stihl Kerstin , Evertsson Linda , Kahn Lorna , Warner Lynsey , Harris Matthew , Zaccariotto Monise , Cardoso Mairciomarcio Mendonca , Madsen Monica Damholt , Pinner Paula Pino , Dekker Paul , Jordaan Pieter , Burke Philip , Bhardwaj Praveen , Wahlstrom Per , Payne Rebecca , Hurley Rhian , Wade Rickie , Hess Sally Anne , Rao Saood Ahmad , Brito Sara , Ewald Sarah , Taplin Sarah , Tan Simon , Dobbs Sophie , Sjerén Stina , Beale Suzanne , Oxley Suzanne , Cole Tanya , Hems Tim , Madura Tomas , Quick Tom , Pondaag Willem 
Published: November 2023

The aim of the present study was to reach international consensus on the minimum set of outcomes to measure and report in adult traumatic brachial plexus injury care and research. This would facilitate comparison of outcomes from different centres and meta-analysis in research. A list of outcomes was developed from a systematic review ( n = 54) and patient interviews ( n = 12). The outcomes were rated in a three-round online Delphi survey completed by international surgeons, patients and therapists. Two online consensus meetings with patients and clinicians ratified the final core outcome set. A total of 72 people (20 surgeons, 21 patients, 31 therapists) from 19 countries completed all survey rounds. Thirty-eight people from nine countries attended separate patient ( n = 13) and clinician consensus ( n = 25) meetings. Outcomes were included if recommended by more than 85% of contributors. Pain, voluntary movement and carrying out a daily routine are the core outcome domains that should be assessed and reported when treating and researching adults with a traumatic brachial plexus injury. Level of evidence V
Does correction of carpal malalignment influence the union rate of scaphoid nonunion surgery?
Authors: McLaughlin Kealan , Jabbar Faizan A. A. , Kelly Luke J. , Jovanovic Iva , Gray Matthew P. , Charalambous Charalambos P. , Harrison John W. K. 
Published: November 2023

The aim of this retrospective study was to assess the relation between carpal malalignment correction and radiological union rates in surgery for scaphoid nonunions. A total of 59 scaphoid waist fracture nonunions treated with open reduction and palmar tricortical autograft were divided according to their pre- and postoperative scapholunate (SL) and radiolunate (RL) angles. We found that carpal malalignment failed to correct in 32 of 59 (54.2%) patients despite meticulous surgical technique and placement of an appropriately sized wedge-shaped graft. In total, 43 (72.9%) fractures united at a mean of 4.47 months (range 3–11). Of the 27 fractures with postoperative SL and RL angles within the normal range, 21 united, whereas 22 of the 32 remaining fractures that failed to achieve postoperative angles within the normal range went on to union. The postoperative SL and RL angles were not related to union. Our findings suggest that in scaphoid fracture nonunion surgery, carpal malalignment may not be corrected in a substantial proportion of patients, but such correction may not be essential for bony union. Our findings also show that there is no marked collapse of the scaphoid graft in the early postoperative period. Level of evidence IV
Mental health and psychosocial support for children with upper limb musculoskeletal conditions
Authors: Persaud Deanna , Hutchison Tamsen , Anthony Samantha J. , Davidge Kristen M. , Clarke Howard M. , Ho Emily S. 
Published: November 2023

This study describes mental health and psychosocial screening processes, access to care and interventions provided to children with upper limb musculoskeletal conditions. A cross-sectional e-survey study was conducted of 107 healthcare professionals who work with children with congenital hand and upper limb differences and brachial plexus birth injuries. Of them, 41 (38%) reported that they routinely screen for mental health and psychosocial concerns. Few (12%) reported the use of standardized outcome measures. In total, 51 (48%) healthcare professionals reported that there was a waiting list for mental health services at their institution. Collectively, healthcare professionals were unsatisfied with the staffing, access to care and types of interventions available. Reported barriers to care included the growing need for mental health support, lack of resources and poor continuity of care after referrals. Future research should focus on identifying and validating a mental health screening tool and investigating the processes affecting access to mental health care. Level of evidence: IV
Adverse childhood experiences and mental ill-health - obesity comorbidity among British adolescents – A national cohort study
Authors: Karamanos Alexis , Khanolkar Amal R. 
Published: November 2023

Background Mental ill-health and obesity are increasingly prevalent in childhood with both conditions likely to co-occur. Less is known about associations between adverse childhood experiences (ACEs) and mental ill-health and obesity (MH-OB) comorbidity in adolescence. The aim of this study was to examine associations between ACEs and MH-OB comorbidity in adolescents from a national cohort study. Methods Participants; 10,734 adolescents (males = 50.3%) from the Millennium Cohort Study with 6 ACEs (for e.g., parental MH, drug/alcohol misuse, physical punishment) collected prospectively between ages 3-11 years. MH-OB comorbidity (binary indicator) was based on objectively measured BMI (for overweight/obesity) and self-reported depression/anxiety at ages 14 and 17. Associations between: 1.total ACE scores (0, 1, 2 or ≥3) and additionally each individual ACE, and MH-OB, were analysed used logistic regression, separately at 14 and 17 years. Results At age 14, ACE scores were associated with higher odds for MH-OB comorbidity, with a gradient of increasing odds ratios (OR) with increasing ACEs. Individuals with 1 (OR:1.22[95%CI: 1.1-1.6]), 2 (OR:1.7[1.3-2.3]), or ≥3ACEs (OR:2[1.5-2.6]) had increased odds for MH-OB comorbidity compared to those with 0 ACEs. At age 17, associations between ACE scores and MH-OB were attenuated and observed in individuals with ≥3ACEs (OR:1.54, 1.1-2.3). Parental MH (OR:1.5, 1.2-1.9), intimate-partner violence (OR:1.2, 1.1-1.6), physical punishment (OR:1.3, 1.1-1.6), bullying (OR:2, 1.6-2.5) were associated with MH-OB comorbidity age 14. However, only parental MH (OR:1.5, 1.1-2.1) and bullying (OR:1.6, 1.2-2.1) were associated with MH-OB comorbidity at age 17. Conclusion ACEs are associated with increased risk of MH-OB comorbidity in between ages 14 and 17. These findings provide timely opportunity for interventions to reduce risk and are pertinent given that MH and obesity contribute significantly to global burden of disease and track across the lifecourse.
Constructing gene similarity networks using co-occurrence probabilities
Authors: Mirzaei Golrokh 
Published: November 2023

AbstractGene similarity networks play important role in unraveling the intricate associations within diverse cancer types. Conventionally, gauging the similarity between genes has been approached through experimental methodologies involving chemical and molecular analyses, or through the lens of mathematical techniques. However, in our work, we have pioneered a distinctive mathematical framework, one rooted in the co-occurrence of attribute values and single point mutations, thereby establishing a novel approach for quantifying the dissimilarity or similarity among genes. Central to our approach is the recognition of mutations as key players in the evolutionary trajectory of cancer. Anchored in this understanding, our methodology hinges on the consideration of two categorical attributes: mutation type and nucleotide change. These attributes are pivotal, as they encapsulate the critical variations that can precipitate substantial changes in gene behavior and ultimately influence disease progression. Our study takes on the challenge of formulating similarity measures that are intrinsic to genes' categorical data. Taking into account the co-occurrence probability of attribute values within single point mutations, our innovative mathematical approach surpasses the boundaries of conventional methods. We thereby provide a robust and comprehensive means to assess gene similarity and take a significant step forward in refining the tools available for uncovering the subtle yet impactful associations within the complex realm of gene interactions in cancer.
Secondary analysis of potential associations between oral health and infection-related parameters in patients with severe heart failure—results of a German cohort
Authors: Schmalz Gerhard , Hennecke Alina , Haak Rainer , Kottmann Tanja , Garbade Jens , Binner Christian , Ziebolz Dirk 
Published: November 2023

Abstract
Objectives
Aim of this retrospective cohort study was to evaluate whether oral health parameters would be associated with infection-related parameters and overall survival of patients with severe heart failure (HF).

Methods
Patients with severe HF, heart transplantation (HTx) and left-ventricular assist device (LVAD), which underwent a full oral examination between 2017 and 2018 were included. Infection-related and survival data were assessed from the patient´s medical records. The oral examination included: remaining teeth, caries and periodontal condition, including periodontal probing depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and diagnosis (staging/grading). In addition, the periodontal inflamed surface area (PISA) was determined. Statistical analysis included Chi-square, Fisher´s exact and Mann-Whitney-U test, as well as a logistic regression, considering age, gender, body-mass-index (BMI), diabetes and several oral health parameters with regard to overall survival and infections at heart/driveline.

Results
329 patients (HTx: 34%, LVAD: 38.9%, HF: 27.1%), were included. Patients had on average 18.96 ± 8.90 remaining teeth, whereby the majority had a periodontitis stage III or IV (88.7%) and a grade B (80.5%). Higher BOP was associated with infections at heart/driveline (p = 0.04) and outside the heart (p < 0.01) during follow-up. Increased PISA was significantly associated with bacterial infections outside the heart (p < 0.01) and sepsis (p = 0.02). Only BMI of 25 or higher correlated with an increased risk of infections at heart/driveline in regression analysis (OR 3.063, CI95 1.158–8.101, p = 0.02), while no associations between oral health parameters and infections at heart/driveline or overall survival were confirmed.

Conclusions
In patients with severe HF, periodontal inflammation might be associated with infection-related parameters. Improved dental care, especially including periodontal therapy and maintenance might be favourable to support prevention of infections in patients with severe HF.
How important is the linearity assumption in a sample size calculation for a randomised controlled trial where treatment is anticipated to affect a rate of change?
Authors: Morgan Katy E. , White Ian R. , Frost Chris 
Published: November 2023

Abstract
Background
For certain conditions, treatments aim to lessen deterioration over time. A trial outcome could be change in a continuous measure, analysed using a random slopes model with a different slope in each treatment group. A sample size for a trial with a particular schedule of visits (e.g. annually for three years) can be obtained using a two-stage process. First, relevant (co-) variances are estimated from a pre-existing dataset e.g. an observational study conducted in a similar setting. Second, standard formulae are used to calculate sample size. However, the random slopes model assumes linear trajectories with any difference in group means increasing proportionally to follow-up time. The impact of these assumptions failing is unclear.

Methods
We used simulation to assess the impact of a non-linear trajectory and/or non-proportional treatment effect on the proposed trial’s power. We used four trajectories, both linear and non-linear, and simulated observational studies to calculate sample sizes. Trials of this size were then simulated, with treatment effects proportional or non-proportional to time.

Results
For a proportional treatment effect and a trial visit schedule matching the observational study, powers are close to nominal even for non-linear trajectories. However, if the schedule does not match the observational study, powers can be above or below nominal levels, with the extent of this depending on parameters such as the residual error variance. For a non-proportional treatment effect, using a random slopes model can lead to powers far from nominal levels.

Conclusions
If trajectories are suspected to be non-linear, observational data used to inform power calculations should have the same visit schedule as the proposed trial where possible. Additionally, if the treatment effect is expected to be non-proportional, the random slopes model should not be used. A model allowing trajectories to vary freely over time could be used instead, either as a second line analysis method (bearing in mind that power will be lost) or when powering the trial.