bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of matrix completion approaches for aquaponics data
Authors: O N Nandesh , Shetty Rikitha , Alva Saniha , Paul Aditi , Sure Pallaviram 
Published: November 2023

Technological innovations in Internet of Things (IoT) have resulted in smart agricultural solutions such as a remotely monitored Aquaponics system and a wireless sensor network (WSN) of such systems (nodes). IoT enables continuous sensing of temperature and pH data at each node of the WSN, which is periodically transmitted to a remote fusion centre. In this regard, the data matrices acquired at the fusion centre often suffer from data vacancies and missing data problems, owing to typical wireless multipath fading environment, sensor malfunctions and node failures. This paper explores the applicability of different matrix completion approaches for missing data reconstruction. Specifically, the performance of baseline predictor, correlation based approaches such as baseline predictor with temporal model, k-nearest neighbors (kNN) and low rank based approaches such as Sparsity Regularized Singular Value Decomposition (SRSVD) and Augmented Lagrangian Sparsity Regularized Matrix Factorization (ALSRMF) have been explored. Reliable temperature and pH data for 19 independent acquisition hours with 60 samples per hour are acquired at the fusion centre via Ultra High Frequency (UHF) transmission at 470 MHz and suitable pre-processing. Simulating different data integrity scenarios, the reconstruction error plots from each of these matrix completion approaches is extracted. A hybrid of kNN and baseline predictor with temporal model rendered a Mean Absolute Percentage Error (MAPE) of 1.75% for temperature and 0.86% for pH, at 0.5 data integrity. Further, with ALSRMF, which exploits the low rank constraint, the error reduced to 1.25% for temperature and 0.7% for pH, thus substantiating a promising approach for Aquaponics system data reconstruction.
Comparative Analysis of Very Reduced vs Full Dose BCG Treatment for High-Risk Non-Muscle Invasive Bladder Cancer: A Contemporary Experience from Chile
Authors: Grajales Valentina , Contieri Roberto , Tan Wei Shen , Flores Marta , Schultz Marcela , Pinochet Rodrigo , Bustamante Alberto , Kamat Ashish M. , Fernández Mario I. 
Published: November 2023

BACKGROUND: Adjuvant bacillus Calmette-Guérin (BCG) is recommended for high-risk (HR) non-muscle invasive bladder cancer (NMIBC), but BCG shortages have led to exploration of reduced-dose regimens and shortened maintenance durations out of necessity, with limited data on treatment efficacy in Latin America. OBJECTIVE: Oncological outcomes of HR-NMIBC patients treated with reduced (RD,1/4th dose) vs full dose (FD) BCG instillations of Danish Strain 1331 BCG. METHODS: We performed a retrospective study of HR-NMIBC patients treated with BCG between 2003 and 2022 at our center in Santiago Chile. We stratified patients according to either RD (1/4th dose) or FD BCG. Univariate and multivariable Cox regression models were used to predict recurrence. Kaplan-Meier method was used to calculate survival estimates. RESULTS: Of a total of 200 patients, 116 (58%) had RD and 84 (42%) FD BCG. Median follow-up was 57 months (IQR: 29–100). Patients who received FD BCG had a lower risk of recurrence (HR: 0.41, 95% CI 0.22–0.74) and high-grade (HG)-recurrence (HR: 0.30, 95% CI 0.15–0.61; p = 0.001). More patients in the RD vs FD group progressed to MIBC (10/84 vs 2/116; p = 0.18). Additionally, patients were less likely to stop BCG treatment in the RD group compared to the FD group due to toxicity (5% vs 11%, p = 0.14). CONCLUSIONS: A 1/4th dose of Danish Strain 1331 BCG treatment was associated with worse recurrence free rate and HG-recurrence rate in our cohort. Patients with RD had lower discontinuation treatment rates due to a reduced toxicity profile. These findings would suggest that RD BCG would compromise oncological outcomes in HR-NMIBC patients.
Moving from piecemeal to systematic: Reprioritizing how academic libraries approach research information management
Authors: MacIsaac Olivia , Polley Ted 
Published: November 2023

This paper is based on a lightening talk given at the 2023 NISO Plus conference. The authors explore how research information management (RIM) workflows at universities are increasingly intersecting with library workflows, particularly regarding compliance with federal funding and preservation of the institution’s scholarly record. This paper outlines one academic library’s plan to shift from thinking about library-supported RIM services as a piecemeal approach to a more systematic approach that prioritizes open infrastructure. Though in its early stages of implementation, the authors seek to examine current RIM systems and services at their institution, expand on the current findings of U.S. activities brought forth in reports produced by OCLC and Lyrasis, and to identify local opportunities for library-supported RIM tools/services that are open and transparent. Specifically, this paper emphasizes the implementation and adoption of persistent identifiers, such as ORCID, but discussion will also cover other RIM systems and services.
Association Between Menopausal Hormone Therapy and Risk for Parkinson’s Disease
Authors: Yuk Jin-Sung , Jeong Seong Ho 
Published: November 2023

Background: The relationship between menopausal hormone therapy (MHT) and risk of Parkinson’s disease (PD) remains controversial. Objective: This nationwide population-based cohort study investigated the association between MHT and PD development. Methods: Data from the National Health Insurance System of South Korea from 2007 to 2020 were used. The MHT group included women who underwent MHT for the first time between 2011–2014, while the non-MHT group included women who visited a healthcare provider for menopause during the same period but never received hormonal therapy. We used propensity score matching (1 : 1) to adjust for potential confounders, and Cox regression models to assess the association between MHT and PD. Results: We selected 303,260 female participants ( n = 151,630 per MHT and non-MHT groups). The median age of the participants was 50 (48–54) years, and the follow-up period lasted 7.9 (6.9–8.9) years. Cox regression analysis revealed an increased risk of PD with MHT (hazard ratio [HR] 1.377, 95% confidence interval [CI] 1.184–1.602), particularly with tibolone (HR 1.554, 95% CI 1.297–1.861) and estrogen alone (HR 1.465, 95% CI 1.054–2.036). Tibolone and estrogen alone were linked to PD within three years; however, no association was observed after three years. In contrast, the use of combined estrogen-progesterone was linked to a higher risk of PD, which increased with the duration of MHT (HR 1.885, 95% CI 1.218–2.918 for over five years). Conclusions: This study demonstrated that the MHT is closely associated with the risk of PD in a regimen- and duration-specific manner.
Deep electrical imaging of the extinct oceanic ridge in the southwestern sub-basin of the South China Sea
Authors: Gao Yan , Li Jianping , Li Fuyuan , Zhang Ruwei , Zhao Yunsheng , He Zhanxiang 
Published: November 2023

The resistivity structure of an extinct mid-ocean ridge is significant in understanding the evolution of a mid-ocean ridge from its spreading phase to its dying phase. The magnetotelluric (MT) method is a crucial tool in studying the deep resistivity structure as it is sensitive to resistivity which is affected by heat and allows for imaging of the electrical properties of the mantle. While modern electromagnetic data has enhanced our understanding of the deep structure of rapidly expanding and ultra-slow expanding mid-ocean ridges, the deep electrical structure below extinct mid-ocean ridges has not been studied extensively.In July 2020, marine MT instruments were deployed in the southwest subbasin of the South China Sea to study the resistivity structure below a stalled mid-ocean ridge. The study found that the imaged thickness of the lithospheric lid (&gt;100Ωm) varies between 20 and 90 km, exhibiting a positive correlation with its age. The melt ascent channel is closed below the stalled mid-ocean ridge, and the melt falls back and forms a small melt trap below the dead mid-ocean ridge. In the northwest survey line of oceanic ridge, huge low-resistivity anomalies (&lt;1Ωm), located between 80km and 160 km depth. In the southeast survey line of oceanic ridge, there is a slightly smaller low-resistivity anomalies (&lt;1Ωm). These results indicate that partial melt continues to exist after the cessation of spreading at the mid-ocean ridge. The lithosphere-asthenosphere boundary (LAB) and the ocean basin of the South China Sea experienced a certain magmatic transformation during the cooling and falling process. According to the resistivity, temperature, pressure, and SEO3 model, the melt content is estimated to be approximately 1-12%. The electrical structure of the mantle in the South China Sea is an important basis for studying the current state beneath the ceased spreading mid-ocean ridge.
Insights on epithelial cells at the single-cell level in hepatocellular carcinoma prognosis and response to chemotherapy
Authors: Qi Wenqian , Zhang Qian 
Published: November 2023

Background: Hepatocellular carcinoma (HCC) originates from Epithelial cells, and epithelial lineage plasticity has become a promising research direction for advancing HCC treatment. This study aims to focus on Epithelial cells to provide target insights for detecting HCC prognosis and response to drug therapy.Methods: Single-cell RNA sequencing (scRNA-seq) data from GSE149614 were clustered using Seurat, and the differentiation and evolution of epithelial cells were analyzed by Monocle 2. Scissor+ and Scissor− Epithelial cells associated with the prognostic phenotypes of bulk RNA-seq of HCC were screened using the Scissor algorithm for differential analysis to screen candidate genes. Candidate genes were overlapped with prognostic related genes screened by univariate Cox regression, and the Least Absolute Shrinkage and Selection Operator (LASSO) sparse penalty was imposed on the intersection genes to construct a risk assessment system.Results: Eight major cell subpopulations of HCC were identified, among which the proportion of epithelial cells in non-tumor liver tissues and HCC tissues was significantly different, and its proportion increased with advanced clinical stage. During the progression of HCC, the whole direction of epithelial cells differentiation trajectory was towards enhanced cell proliferation. Differential analysis between Scissor+ and Scissor− epithelial cells screened 1,265 upregulated and 191 downregulated prognostic candidate genes. Wherein, the upregulated genes were enriched in Cell processes, Genetic information processing, Metabolism and Human disease with Infection. Nevertheless, immune system related pathways took the main proportions in downregulated genes enriched pathways. There were 17 common genes between upregulated candidate genes and prognostic risk genes, of which CDC20, G6PD and PLOD2 were selected as components for constructing the risk assessment system. Risk score showed a significant correlation with tumor stage, epithelial-mesenchymal transition (EMT) related pathways and 22 therapeutic drugs, and was an independent prognostic factor for HCC.Conclusion: This study revealed the cellular composition of HCC, the differentiation evolution and functional landscape of epithelial cells in the further deterioration of HCC, and established a 3-gene risk model, which was closely related to clinical features, EMT, and drug sensitivity prediction. These findings provided insights in patient prognosis and drug therapy detection for HCC.
Centering community-based knowledge in food security response and climate resilience in southern Madagascar
Authors: Zambiazzi Emily , Carr Elizabeth , Mahazotahy Sylvain , Mahafake Charles , Dickey Chris 
Published: November 2023

ObjectiveIncreasingly unpredictable shifts in climate are triggering public health crises globally. Southern Madagascar is particularly vulnerable to climate impacts, despite contributing to only 0.2% of global emissions. Though endemic in Madagascar, climate impacts such as below average rainfall have increased the severity of droughts, putting over half of the population in southern regions at risk of being food insecure in 2022. The following review examines: How can interventions surrounding the current food emergency in southern Madagascar center community-based knowledge in their strategies? Through a social-ecological approach, this review aims to holistically discuss the complexity of the climate and food crises in this region, which is a topic that has not been widely covered in published review articles thus far.MethodsWe took a comprehensive and social-ecological approach by analyzing research pertaining to the impacts of colonial history, politics, economy, and culture on the current climate, ecology, and food systems of southern Madagascar.Main findingsMany current strategies to mitigate climate impacts and food security fail to incorporate community-based knowledge, leading to inequitable and ineffective interventions. Researchers who prioritize historical and cultural context illustrate how local knowledge may serve as a protective factor against climate impacts.ConclusionsAs climate shifts exacerbate public health crises, aid organizations must center community perspectives in their interventions to foster equitable and sustainable outcomes.
Drug Correction of Cognitive and Psycho-Emotional Disorders in Menopausal Women
Authors: Зейналова Х.П. , Ахундова Н.Э. , Исмайлова А.Дж. , Джафарова Т.Ф. 
Published: November 2023

В настоящее время наблюдается увеличение численности старшей возрастной группы, и это определяет возникновение новых вопросов, связанных с возраст-ассоциированными заболеваниями. Выявлена прямая связь между частотой жалоб на изменение когнитивной активности и началом нарушения менструальной функции, т. е. старением репродуктивной системы, что, в свою очередь, приводит к снижению уровня половых гормонов. Определяется зависимость между соотношением эстрогенов, прогестерона, андрогенов и когнитивной активностью женщин. Современные теории «здоровых клеток» и «эуэстрогении» объясняют влияние дополнительных критериев, таких как отсутствие неврологических расстройств и длительность гипоэстрогении, на результат менопаузальной гормональной терапии (МГТ). Другие факторы, как например: состав гормональной терапии, дозы, методы введения, эндокринные заболевания, гинекологический анамнез, наследственность, оказывают дополнительное влияние на эффекты МГТ. Проведенные исследования отражают результаты влияния МГТ на предотвращение или уменьшение риска развития депрессии, нарушения сна и ментальных способностей. В работе отмечаются и результаты отрицательного или нейтрального влияния МГТ на женщин. Противоречивость данных исследований определяет необходимость продолжения научных поисков в этом направлении гинекологии.
There is an increase the number of the older age group and this determines the emergence of new issues related to age-associated diseases. Revealed a direct relationship with the onset of menstrual dysfunction, i.e. “aging” of the reproductive system, which in turn leads to a decrease in sex hormones. The relationship between the ratios of estrogens, progesterone, androgens and the cognitive activity of women is determined. Modern theories of “healthy cells” and “euestrogeny” explain the influence of additional criteria, such as theabsence of neurological disorders and the duration of hypoestrogenism on the outcome of menopausal hormone therapy, doses, methods of administration, endocrine diseases, gynecological hystory, heredity have an additional influence on the effects of MHT. The studies carried out reflect the results of the influence of MHT on preventing or reducing the risk of developing depression,sleep disturbance and mental abilities. Scientific work also notes the results of the negative or neutral influence of MHT on women. The inconsistency of these studies determines the need to continue scientific research in this area of gynecology.
Processo de construção remota do plano de ação nacional para conservação dos insetos polinizadores ameaçados de extinção
Authors: Cascelli Farinasso Hannah , Benicio de Castro Lucas , Rodrigo Rech André , Canto Resende Helder , Lepesqueur Cintia , Moreira Martins Ana Carolina , Steenbock Walter , Hipólito Juliana , Freitas de Oliveira Favízia , J Marini-Filho Onildo 
Published: November 2023

Os planos de ação nacional (PANs) constituem importantes instrumentos para a conservação da biodiversidade ameaçada de extinção. Este trabalho objetiva analisar o processo de elaboração do PAN Insetos Polinizadores, realizado em formato virtual, pela primeira vez no contexto dos PANs (devido Ã s restrições sanitárias do período da pandemia de Covid-19). Especificamente, buscamos responder Ã s seguintes perguntas: 1) Quais as adaptações desenvolvidas para a metodologia virtual? 2) Quais os resultados alcançados pela construção remota? 3) Quais as vantagens e desvantagens do uso do ambiente virtual? 4) Como as lições aprendidas com o formato virtual podem contribuir para os próximos PANs? A metodologia desenvolvida se baseou em reuniões online e atividades assíncronas, utilizando ferramentas como formulários, quadro digital e planilhas compartilhadas. Após as reuniões, foram aplicados formulários de avaliação visando coletar impressões dos participantes e sugerir melhorias no método. No geral, o formato virtual foi bem aceito por parte dos participantes e foi possível atender aos requisitos para a validação do Plano. A participação de uma equipe de apoio com experiência em PANs e com disponibilidade para a preparação do material para os encontros virtuais mostrou-se indispensável durante todo o processo para alcançar os objetivos. O formato virtual trouxe vantagens, como menor custo, maior número de colaboradores (homens e mulheres) e objetividade em relação ao uso do tempo. Como desvantagens, observou-se menor envolvimento dos participantes e dinâmicas de facilitação menos enriquecedoras. Vale destacar que o modelo virtual aqui desenvolvido para a elaboração de PANs pode ser utilizado ou adaptado para PANs futuros.Â
Espécies exóticas invasoras nos planos de ação nacional para a conservação das espécies ameaçadas de extinção
Authors: Menezes Cruz Marangon Gabriela , Galvão Amanda , Correa Seabra Guimarães Tainah , Marques Guimarães Marini Marília 
Published: November 2023

As espécies exóticas invasoras são uma grande ameaça Ã biodiversidade brasileira atualmente, e o conhecimento de como se comportam na natureza ajuda a combatê-las através das ações presentes nos planos de ação nacional. Estes representam uma ferramenta participativa importante para a conservação da fauna e flora brasileira, pois são elaborados e implementados em conjunto com a sociedade. Através da análise das espécies exóticas invasoras na Lista Oficial de Espécies Ameaçadas de Extinção da Fauna Brasileira e nas ações dos planos, foi possível identificar que 186 (16%) das espécies ameaçadas apresentam espécies exóticas invasoras como ameaça e que, em 35 planos de ação, há 158 ações envolvendo espécies exóticas invasoras, das quais 43% não possuem bom andamento. A partir desse diagnóstico, propomos sugestões para fortalecer o enfrentamento Ã s invasões biológicas, como aperfeiçoamento da qualidade de informações sobre espécies exóticas invasoras no processo de avaliação no risco de extinção da fauna, maior integraçãoentre ações e planos de ação nacional, maior envolvimento de instituições locais e melhor articulação intra e interinstitucional.
Software Defect Prediction Using Non-Dominated Sorting Genetic Algorithm and $k$-Nearest Neighbour Classifier
Authors: Azzeh Mohammad , Nassif Ali Bou , Abu Talib Manar , Iqbal Hajra 
Published: November 2023

Background: Software Defect Prediction (SDP) is a vital step in software development. SDP aims to identify the most likely defect-prone modules before starting the testing phase, and it helps assign resources and reduces the cost of testing.
Aim: Although many machine learning algorithms have been used to classify software modules based on static code metrics, the k-Nearest Neighbors (kNN) method does not greatly improve defect prediction because it requires careful set-up of multiple configuration parameters before it can be used. To address this issue, we used the Non-dominated Sorting Genetic Algorithm (NSGA-II) to optimize the parameters in the kNN classifier with favor to improve SDP accuracy. We used NSGA-II because the existing accuracy metrics often behave differently, making an opposite judgment in evaluating SDP models. This means that changing one parameter might improve one accuracy measure while it decreases the others.
Method: The proposed NSGAII-kNN model was evaluated against the classical kNN model and state-of-the-art machine learning algorithms such as Support Vector Machine (SVM), Naïve Bayes (NB), and Random Forest (RF) classifiers.
Results: Results indicate that the GA-optimized kNN model yields a higher Matthews Coefficient Correlation and higher balanced accuracy based on ten datasets.
Conclusion: The paper concludes that integrating GA with kNN improved defect prediction when applied to large or small or large datasets.
MOUND 1/2021 OF THE SKOROBIR NECROPOLIS IN THE DISTRICT OF BILSK GORODYSHCHE
Authors: Shramko I. B. 
Published: November 2023

The article introduces the burial complex investigated in 2021 by a joint expedition of the Historical and Cultural Reserve «Bilsk» and V. N. Karazin Kharkiv National University in the Skorobir burial mound necropolis in the western district of the Bilsk settlement. Despite the fact that the burial mound was looted in ancient times, it was possible to trace the peculiarities of the creation of the burial structure and the main features of the burial rite.
A burial site was discovered under the barrow mound, which was looted back in ancient times. Only a small part of this complex remained intact. The burial chamber was a simple rectangular pit with an area of 7.15 m2, oriented along the northeast-southwest line. A 2.75 m long dromos adjoined the pit from the southwest, which was recorded for the first time in the necropolises of the Bilsk fortified settlement for burials of the Early Scythian period. The floor of the grave was lined with longitudinal wooden boards, which were placed on transverse logs, fixed in grooves dug near the southern and northern walls of the grave. The grave was not covered with soil, it was covered with wooden logs, the remains of which were fixed. Molded pottery (bowls, ladles, and ladles) was left on the ceiling, which fell into the burial chamber after the ceiling was destroyed. Based on the categories of funeral inventory it can be said with certainty that a woman was buried in the grave with her head facing southwest. Beads made of glass and rock crystal, as well as gold rosette plaques, indicate the rather high social status of the deceased, who probably belonged to representatives of the local elite. The set of accompanying inventory allows us to date the burial in barrow 1/2021 to the first quarter of the 6th century BC.
Mound 1/2021 demonstrates the close burial traditions of the local population of the Early Scythian period and has certain correspondences among the mounds of the Bilsk burial grounds, first of all, the burial complexes of the first half of the 6th century BC, which have been studied in recent years in the southern part part of the Skorobir necropolis, the largest of those located near the Bilsk fortified settlement. The traced general features of the burial rite are typical for the burial mounds of the Bilsk hillfort.