bluuebunny/crossref_metadata_2025_split huggingface dataset:
Follow-up ASPECTS improves prediction of potentially lethal malignant edema in patients with large middle cerebral artery stroke
Authors: Stafford Rebecca , Chatzidakis Stefanos , Kim Ivy So Yeon , Zhang Yihan , Rina Andriani , Brush Benjamin , Mian Asim , Abdalkader Mohamad , Greer David M , Smirnakis Stelios M , Feske Steven K , Dupuis Josée , Ong Charlene J 
Published: December 2023

BackgroundRecent studies have shown that follow-up head CT is a strong predictor of functional outcomes in patients with middle cerebral artery stroke and mechanical thrombectomy. We sought to determine whether total and/or regional follow-up Alberta Stroke Program Early CT Score (ASPECTSfu) are associated with important clinical outcomes during hospitalization and improve the performance of clinical prediction models of potentially lethal malignant edema (PLME).MethodsWe conducted a retrospective study of patients at three medical centers in a major North American metropolitan area with baseline and follow-up head CTs after large middle cerebral artery stroke between 2006 and 2022. We used multivariable logistic regression to test the association of total and regional ASPECTSfuwith PLME (cerebral edema related death or surgery), adjusting for total baseline ASPECTS, age, sex, admission glucose, tissue plasminogen activator, and mechanical thrombectomy. We compared existing clinical risk models with and without total or regional ASPECTSfuusing area under the curve.ResultsIn our 560 patient cohort, lower total ASPECTSfuwas significantly associated with higher odds of PLME when adjusting for confounders (OR 1.69, 95% CI 1.49 to 2.0), and improved model discrimination compared with existing models and models using baseline ASPECTS. Deep territory involvement (OR 2.46, 95% CI 1.53 to 4.01) and anterior territory involvement (OR 3.23, 95% CI 1.88 to 5.71) were significantly associated with PLME.ConclusionsLower ASPECTSfuand certain locations on regional ASPECTSfu, including deep and anterior areas, were significantly associated with PLME. Including ASPECTSfuinformation improved discrimination of established edema prediction models and could be used immediately to help facilitate clinical management decisions and prognostication.
Tobacco, nicotine and counter-marketing promotions using Instagram’s branded content tool
Authors: Laestadius Linnea , Van Hoorn Kelsey , Vassey Julia , Ozga Jenny , Stanton Cassandra , Li Dongmei , Han Eileen , Romer Daniel 
Published: December 2023

BackgroundThe social media conglomerate, Meta, has a policy prohibiting promotion of tobacco products, vaporisers, electronic cigarettes or other products that simulate smoking via their branded content tools. This study examines if branded Instagram posts comply with these self-regulatory efforts.MethodsWe analysed the presence and content of tobacco/nicotine promotion, as well as counter-marketing, in a sample of 400 branded/paid partnership-labelled Instagram posts with tobacco/nicotine-related terms made between 31 July 2022 and 31 March 2023, gathered from Meta’s CrowdTangle tool and classified by CrowdTangle as being in English.ResultsOf the 217 active branded posts that mentioned or depicted tobacco/nicotine products, most promoted rather than countered the sale of such products (84.3% vs 15.7%, respectively). Posts originating from US Instagram users accounted for 42.6% of promotional content. After the USA, posts from Indonesia (19.1%), Pakistan (9.8%) and India (8.2%) were most frequent. Most posts were fully in English (74.9%). Posts featured hookah (39.4%), electronic nicotine delivery systems (ENDS) accessories (17.5%), ENDS devices and e-liquids (16.9%) and various types of cigars (15.3%). The majority of US posts promoted venues or events where tobacco/nicotine products were featured (71.8%). Almost half of all promotional posts (47.0%) were sponsored by tobacco industry accounts. Posts that encouraged cessation were primarily (47.1%) sponsored by non-government organisations.ConclusionDespite attempts at self-regulation, paid partnership posts promoting tobacco and nicotine products are present on Instagram, especially posts promoting venues and events that feature tobacco and nicotine use. Self-regulation of this content shows limited success, suggesting a need for federal oversight and additional counter-marketing in social media settings.
Genetic and T2 biomarkers linked to the efficacy of HDM sublingual immunotherapy in asthma
Authors: Hoof Ilka , Bønnelykke Klaus , Stranzl Thomas , Brand Stephanie , Li Xingnan , Shamji Mohamed H , Meyers Deborah A , Bateman Eric D , Bleecker Eugene , Andersen Peter Sejer 
Published: December 2023

BackgroundHypersensitivity to house dust mite (HDM) allergens is a common cause of allergic asthma symptoms and can be effectively treated with allergy immunotherapy (AIT).ObjectiveTo investigate whether genetic and type 2 (T2) inflammatory biomarkers correlate with disease severity in subjects with allergic asthma, and whether this can be modified by AIT.MethodsMITRA (NCT01433523) was a phase III, randomised, double-blind, placebo-controlled trial of HDM sublingual immunotherapy (SLIT)-tablets in adults with HDM allergic asthma. Post hoc analyses of the study population (N=742) evaluated associations between T2 inflammatory (blood eosinophils, eosinophil cationic protein (ECP), total IgE and tryptase) and genetic (single-nucleotide polymorphisms, SNP) biomarkers (n=582) for the primary study endpoint (time to first moderate/severe asthma exacerbation). SNP associations were verified in HDM-positive subgroup from an independent 3-year Severe Asthma Research Programme (SARP3) subject cohort.ResultsAn increased asthma exacerbation risk in subjects homozygous for SNP rs7216389 (chromosomal locus 17q12-21) was reduced (p=0.037) by treatment with HDM SLIT (HR=0.37 (95% CI 0.22 to 0.64), p<0.001). The associations between exacerbation risk and 17q12-21 SNPs were replicated in the SARP3 HDM-positive subgroup. High levels of T2 biomarkers were associated with increased risk of asthma exacerbations in the placebo group. HDM SLIT-tablet treatment reduced this risk (blood eosinophils: HR=0.50 (95% CI 0.30 to 0.85); ECP: HR=0.45 (95% CI 0.29 to 0.87); tryptase: HR=0.45 (95% CI 0.25 to 0.80)). The treatment effect was higher (p=0.006) for subjects with a higher number of elevated T2 biomarkers.ConclusionsHDM SLIT-tablet AIT is efficacious in HDM-sensitised asthma subjects with a genetic asthma predisposition and/or an underlying T2 endotype.Trial registration numberNCT01433523.
The effect of noncommutativity on the charged 4D-EGB black hole in AdS space–time
Authors: Lekbich H. , Boukili A. El , Sekhmani Y. , Sedra M. B. 
Published: December 2023

In this paper, we obtain a solution of a static spherically symmetric charged black hole inspired by noncommutative geometry in the context of the regularized 4D-Einstein–Gauss–Bonnet theory in AdS space. The derived metric recovers the standard solutions’ limits. It tends to the commutative case solution found in [P. G. S. Fernandes, Phys. Lett. B 805, 135468 (2020)] at large distance [Formula: see text] and the general relativity solution with smeared mass and charge as [Formula: see text]. The charged solution obtained is singular at the origin in contrast to its neutral version, which is regular. The thermodynamic quantities have been modified due to the influence of noncommutativity. The heat capacity was used to investigate the local thermal stability. The black hole has been discovered to be locally stable for small and large radii, but unstable for middle radii.
A Deep Vision Sensing-Based Smart Control Method for Apple-Picking Robots Under the Context of Agricultural E-Commerce
Authors: Qiu Yang , Yang Man 
Published: December 2023

The growing development of the agricultural e-commerce industry is promoting the Digital transformation of agricultural production and logistics. Aiming at the problem of labor shortage in apple picking, this paper proposes a performance control method for robot apple picking based on a nonlinear wide convolutional neural network (NLWCNN) and multi-objective cooperative distance transformation algorithm (MOCDTA). This method utilizes deep learning algorithms and visual sensing technology to enable robots to accurately recognize apples and perform autonomous picking operations based on their maturity and position. We have designed a machine learning-based algorithm that enables robots to accurately recognize and distinguish apples of different maturity levels through training on a large amount of sample data. At the same time, we also combined the motion control algorithm of the robot to enable efficient picking operations based on the position and maturity information of the apples. The experimental results indicate that the NLWCNN method can significantly improve the efficiency and accuracy of apple picking, ensure the safety and traceability of agricultural products, increase consumer trust, and promote agricultural product transactions.
Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A
Authors: Ishimaru Kosei , Ikeda Masataka , Miyamoto Hiroko Deguchi , Furusawa Shun , Abe Ko , Watanabe Masatsugu , Kanamura Takuya , Fujita Satoshi , Nishimura Ryohei , Toyohara Takayuki , Matsushima Shouji , Koumura Tomoko , Yamada Ken‐ichi , Imai Hirotaka , Tsutsui Hiroyuki , Ide Tomomi 
Published: December 2023

Background
Ferroptosis, an iron‐dependent form of regulated cell death, is a major cell death mode in myocardial ischemia reperfusion (I/R) injury, along with mitochondrial permeability transition‐driven necrosis, which is inhibited by cyclosporine A (CsA). However, therapeutics targeting ferroptosis during myocardial I/R injury have not yet been developed. Hence, we aimed to investigate the therapeutic efficacy of deferasirox, an iron chelator, against hypoxia/reoxygenation‐induced ferroptosis in cultured cardiomyocytes and myocardial I/R injury.

Methods and Results
The effects of deferasirox on hypoxia/reoxygenation‐induced iron overload in the endoplasmic reticulum, lipid peroxidation, and ferroptosis were examined in cultured cardiomyocytes. In a mouse model of I/R injury, the infarct size and adverse cardiac remodeling were examined after treatment with deferasirox, CsA, or both in combination. Deferasirox suppressed hypoxia‐ or hypoxia/reoxygenation‐induced iron overload in the endoplasmic reticulum, lipid peroxidation, and ferroptosis in cultured cardiomyocytes. Deferasirox treatment reduced iron levels in the endoplasmic reticulum and prevented increases in lipid peroxidation and ferroptosis in the I/R‐injured myocardium 24 hours after I/R. Deferasirox and CsA independently reduced the infarct size after I/R injury to a similar degree, and combination therapy with deferasirox and CsA synergistically reduced the infarct size (infarct area/area at risk; control treatment: 64±2%; deferasirox treatment: 48±3%; CsA treatment: 48±4%; deferasirox+CsA treatment: 37±3%), thereby ameliorating adverse cardiac remodeling on day 14 after I/R.

Conclusions
Combination therapy with deferasirox and CsA may be a clinically feasible and effective therapeutic approach for limiting I/R injury and ameliorating adverse cardiac remodeling after myocardial infarction.
Cardiovascular Risk Stratification of Patients Undergoing Hematopoietic Stem Cell Transplantation: The CARE‐BMT Risk Score
Authors: Vasbinder Alexi , Catalan Tonimarie , Anderson Elizabeth , Chu Catherine , Kotzin Megan , Murphy Danielle , Cheplowitz Halle , Diaz Kristen Machado , Bitterman Brayden , Pizzo Ian , Huang Yiyuan , Xie Jeffrey , Hoeger Christopher W. , Kaakati Rayan , Berlin Hanna P. , Shadid Husam , Perry Daniel , Pan Michael , Takiar Radhika , Padalia Kishan , Mills Jamie , Meloche Chelsea , Bardwell Alina , Rochlen Matthew , Blakely Pennelope , Leja Monika , Banerjee Mousumi , Riwes Mary , Magenau John , Anand Sarah , Ghosh Monalisa , Pawarode Attaphol , Yanik Gregory , Nathan Sunita , Maciejewski John , Okwuosa Tochukwu , Hayek Salim S. 
Published: December 2023

Background
Evidence guiding the pre‐hematopoietic stem cell transplantation (HSCT) cardiovascular evaluation is limited. We sought to derive and validate a pre‐HSCT score for the cardiovascular risk stratification of HSCT candidates.

Methods and Results
We leveraged the CARE‐BMT (Cardiovascular Registry in Bone Marrow Transplantation) study, a contemporary multicenter observational study of adult patients who underwent autologous or allogeneic HSCT between 2008 and 2019 (N=2435; mean age at transplant of 55 years; 4.9% Black). We identified the subset of variables most predictive of post‐HSCT cardiovascular events, defined as a composite of cardiovascular death, myocardial infarction, heart failure, stroke, atrial fibrillation or flutter, and sustained ventricular tachycardia. We then developed a point‐based risk score using the hazard ratios obtained from Cox proportional hazards modeling. The score was externally validated in a separate cohort of 919 HSCT recipients (mean age at transplant 54 years; 20.4% Black). The risk score included age, transplant type, race, coronary artery disease, heart failure, peripheral artery disease, creatinine, triglycerides, and prior anthracycline dose. Risk scores were grouped as low‐, intermediate‐, and high‐risk, with the 5‐year cumulative incidence of cardiovascular events being 4.0%, 10.3%, and 22.4%, respectively. The area under the receiver operating curves for predicting cardiovascular events at 100 days, 5 and 10 years post‐HSCT were 0.65 (95% CI, 0.59–0.70), 0.73 (95% CI, 0.69–0.76), and 0.76 (95% CI, 0.69–0.81), respectively. The model performed equally well in autologous and allogeneic recipients, as well as in the validation cohort.

Conclusions
The CARE‐BMT risk score is easy to calculate and could help guide referrals of high‐risk HSCT recipients to cardiovascular specialists before transplant and guide long‐term monitoring.
Bishopric as an Ascent to Philosophy
Authors: Miroshnichenko Eugene I. 
Published: December 2023

Abstract
The article delves into the issue of Synesius of Cyrene’s Christianity. While scholars like D. Roques and Alan Cameron have argued that Synesius was a Christian due to his birth into a Christian family, the author disputes these presumptions. Instead, the author proposes that the question should be approached differently. Specifically, the problem lies not in determining whether Synesius was a Christian or a pagan but in understanding how he, as a Hellenic figure, interpreted Christianity. While we lack reliable information about whether he was ever baptized, we can confidently conclude – based on his view of the bishopric as a means to philosophy – that he did not adhere to Christianity in the traditional sense. Instead, Synesius could be considered a Hellenic believer who leveraged a Christian bishopric to sustain the traditional education and culture of Hellenism in the context of the Christian empire.
Psychometric Validation of the Tactical Assessment Instrument in Football for Use in Physical Education and with Youth Sport Teams
Authors: Barquero-Ruiz Carmen , Kirk David , Meroño Lourdes , Arias-Estero José L. 
Published: December 2023

Recently, the Tactical Assessment Instrument in Football (TAIS) was developed to address football’s tactical requirements in terms of game phases, learners’ roles, and organizational levels of play. In this study, we sought to evaluate the psychometric properties of this existing instrument in the Physical Education (PE) context and for youth sport teams (ages 8–12 years). Our research design involved: (a) participants playing 37 football games, (b) assessing participants via observation with the TAIS and (c) conducting psychometric analysis on the obtained assessment data. For the psychometric analysis, we carried out our work in four phases: (a) a statistical analysis of the evaluation criteria, (b) analysis of the instrument’s structural dimensions, (c) internal item reliability analysis, and (d) provision of evidence for external validity. Participants were 592 children (156 girls, 436 boys; ages 8–12 years) from 74 PE classes or sport teams (from three institutional contexts - schools, community-based sports, and sports clubs) in Spain. We selected 12 tactical criteria and grouped them into four theoretical dimensions (appropriate attack, inappropriate attack, appropriate defense, inappropriate defense) to confirm the instrument’s structural dimensions. The Cronbach alpha and Omega McDonald coefficients were greater than .70. The TAIS discriminated between participants from the three institutional contexts, offering evidence of the instrument’s external validity. Thus, the TAIS now has sufficient psychometric support for assessing learning of football tactics in PE and youth sport teams. This instrument facilitates an ecological assessment of youth players’ understanding of football tactics through four theoretical tactical dimensions and 12 criteria involving information about four learners’ roles (both attack and defense, on- and off-the-ball) and three organizational tactical levels of play (whole team, small groups of learners, and individual learners).
Outcomes of COVID-19 patients undergoing extracorporeal membrane oxygenation: A systematic review and meta-Analysis
Authors: Jiang Shouliang , Yan Ping , Ma Zhongyang , Liang Juan , Hu Yong , Tang Jun 
Published: December 2023

Background The Coronavirus Disease 2019 (COVID-19) pandemic has been ongoing for over 3 years, during which numerous clinical and experimental studies have been conducted. The objective of this systematic review and meta-analysis was to assess the survival probability and complications of COVID-19 patients receiving extracorporeal membrane oxygenation (ECMO). Methods We searched the databases by using Population-Intervention-Comparison-Outcome-Study Design (PICOS). We conducted a search of the PubMed, Web of Science, and EMBASE databases to retrieve studies published until December 10, 2022. A random-effects meta-analysis, subgroup analysis, and assessed the studies using the Newcastle-Ottawa Scale score. The results were presented as pooled morbidity with 95% confidence intervals. Results The study was conducted on 19 studies that enrolled a total of 1494 patients, and the results showed a pooled survival probability of 66.0%. The pooled morbidity for intracranial hemorrhage was 8.7%, intracranial thrombosis 7.0%, pneumothorax 9.0%, pulmonary embolism 11.0%, pulmonary hemorrhage 9.0%, heart failure 14.0%, liver failure 13.0%, renal injury 44.0%, gastrointestinal hemorrhage 6.0%, gastrointestinal ischemia 6.0% and venous thrombosis 31.0%. Conclusion This systematic review and meta-analysis of observational studies focused on the survival probability and complications of COVID-19 patients undergoing ECMO, which are significant in evaluating the use of ECMO in COVID-19 patients and provide a basis for further research. Trial registration Our study was registered on PROSPERO with registration number CRD42022382555.
Neural correlates of episodic memory decline following electroconvulsive therapy: An exploratory functional magnetic resonance imaging study
Authors: Petersen Jeff Zarp , Macoveanu Julian , Ysbæk-Nielsen Alexander Tobias , Kessing Lars Vedel , Jørgensen Martin Balslev , Miskowiak Kamilla Woznica 
Published: December 2023

Background: Electroconvulsive therapy (ECT) is an efficient and rapid-acting treatment indicated for severe depressive disorders. While ECT is commonly accompanied by transient memory decline, the brain mechanisms underlying these side effects remain unclear. Aims: In this exploratory functional magnetic resonance (fMRI) study, we aimed to compare effects of ECT versus pharmacological treatment on neural response during episodic memory encoding in patients with affective disorders. Methods: This study included 32 ECT-treated patients (major depressive disorder (MDD), n = 23; bipolar depression, n = 9) and 40 partially remitted patients in pharmacological treatment (MDD, n = 24; bipolar disorder, n = 16). Participants underwent neuropsychological assessment, a strategic picture encoding fMRI scan paradigm, and mood rating. The ECT group was assessed before ECT (pre-ECT) and 3 days after their eighth ECT session (post-ECT). Results: Groups were comparable on age, gender, and educational years ( ps ⩾ 0.05). Within-group analyses revealed a selective reduction in verbal learning and episodic memory pre- to post-ECT ( p = 0.012) but no decline in global cognitive performance ( p = 0.3). Functional magnetic resonance imaging analyses adjusted for mood symptoms revealed greater activity in ECT-treated patients than pharmacologically treated No-ECT patients across left precentral gyrus (PCG), right dorsomedial prefrontal cortex (dmPFC), and left middle frontal gyrus (MFG). In ECT-treated patients, greater decline in verbal learning and memory performance from pre- to post-ECT correlated with higher PCG response ( r = −0.46, p = 0.008), but not with dmPFC or MFG activity ( ps ⩾ 0.1), post-ECT. Conclusions: Episodic memory decline was related to greater neural activity in the left PCG, but unrelated to increased dmPFC and MFG activity, immediately after ECT.