Clinical study of benign endometrial hyperplasia and response of Unani drugs with estimation of serum oestrogen levels
Authors:   Department	of	Surgery,	Government	Nizamia	Tibbi	College,	Hyderabad,	Telangana	500002,	India, Samreen , Ateka , Sultana Shahzadi ,   Department	of	Ilmul	Qabalat	Wa	Amraz	e	Niswan,	Government	Nizamia	Tibbi	College,	Hyderabad,	Telangana	500002,	India
Published: February 2024

Endometrial	Hyperplasia	represents	a	spectrum	of	irregular	morphological	alterations,	made	by	abnormal	proliferation	of	the	endometrial	glands	results	in	an	increase	in	gland	to	stroma	ratio.	When	compared	to	endometrium	from	proliferation	phase	of	the	cycle.	The	proliferation	glands	in	endometrial	hyperplasia	can	vary	greatly	in	size	and	shape,	and	cytological	atypia	may	be	present.	According	to	Hakeem	Ajmal	Khan	in	his	book	HAZIQ,Hakeem	Anwer	Ali	Khan	in	his	book	Taleem-ul	Qabela	and	Hakeem	Shafaqat	Azmi	in	his	book	Amraaz	–e-	Niswaan	said	that	the	Endometrial	hyperplasia	is	caused	due	to	alteration	of	humors	and	the	temperament	of	uterus	and	the	increase	in	retaining	power	(quwat-e-	masika)	of	uterus	is	the	cause	of	thickening	of	inner	layer	of	uterus	which	leads	to	warm-e-	daroone-	raham.	Objective:	To	prove	the	eficacy	of	Unani	medicine	in	Benign	Endometrial	Hyperplasia	Methodology:	The	study	was	carried	out	in	the	P.G	Department	of	Qabalath	–	O	–	Amraaz	–	E	–	Niswaan	at	Government	Nizamia	Tibbi	College	and	Hospital,	Charminar,	Hyderabad.	Randomized	single	blind	study	with	Pre	and	Post-test	evaluation	was	conducted.	Total	40	cases	of	Endometrial	Hyperplasia	were	selected	which	is	divided	into	two	Groups.	Group	A	–	20	Cases	and	Group	B	–	20	Cases.	Inclusion	Criteria:	Age	25Yrs.	to	55	Yrs.,	Only	married	women,	Simple	Hyperplasia	with	cystic	without	atypia,	Complex	hyperplasia	with	adenomatous	without	atypia,	History	of	irregular	menstrual	cycles,	PCOD's,	Hormone	replacement	therapy	(HRT).	Exclusion	Criteria:	Simple	Hyperplasia	with	cystic	Atypia,	Complex	Hyperplasia	with	Adenomatous	Atypia/Carcinoma	in	Situ,	Uterine	Fibroids,	Uterine	Polyps,	PID	(Pelvic	Inlammatory	Disease),	Systemic	Disorders	like	tuberculosis,	heart	Diseases,	Renal	Disorders	&	Neurological	Disorder,	Unmarried	Women.	Drugs	which	were	selected	for	trial	were	inalized	on	the	basis	of	these	following	properties	like	Mohalil	–	e-	Aoram,	Qhabiz,	Musafi	–	E	–	Khoon	&	Dafae	Tafoon	were	selected	for	the	study.	In	group	A	&	B	drugs	given	in	the	form	of	Joshanda,	Sufoof,	Humool	and	Zimaad.	Group	A-	JOSHANDA:	Gul	–	e	–	Banafsha,	Babuna,	Tukhm	–	e	–	Kataan,	Sumbul	e	Tib,	Gul	–	e	–	Tisu,	Makoh	–	e	–	Khuskh,	Arjun	Chall,	Gul	–	e	–	Surkh.	HUMOOL:	Mazo,	Gul	–	e	–	Surkh,	Shib	–	e	–	Yamani,	Chub	Zard,	Zulal	–	e-	Tukhme	Bartang.	SUFOOF:	Musli	Safaid,	Mushtagi,	Mochras,	Gul	–	e	–	Surkh,	Maye	Kalan.	ZIMAAD:	Gul-	e	–	Banafsha,	Makoh	–	e	–	khuskh,	Magaz	–	e	–	Fuloos	–	e-	Qayashambar,	Kashneez	–	e-	Sabz,	Tukhme	Alsi.	Group	B	–	JOSHANDA:	Gul	–	e	–	Banafsha,	Babuna,	Tukhm	–	e	–	Kataan,	Sumbul	e	Tib,	Gul	–	e	–	Tisu,	Makoh	–	e	–	Khuskh,	Arjun	Chall,	Gul	–	e	–	Surkh.	HUMOOL:	Luab	–	e	–	Tukhme	Alsi,	Luab	–e-	Tukhme	Khatmi,	Aab	–	e	–	Kashneez	Sabz,	Gul	–	e-	Surkh,	Makoh	–	e	–	Khushk.	SUFOOF:	Gul	–	e	–	Dhava,	Gul-	e-	Gaozaban,	Gul	–	e-	Surkh,	Gul	–	e	–	Banafsha.	ZIMAAD:	Gul	–	e	–	Tisu,	Gul	–	e	–	Banafsha,	Raswat,	Tukhme	Alsi,	Magz	–	e	–	Gheegawar.	Results:	Group	A	8	patients	(40%)	cured;	7	patients	(35%)	Partially	relieved.	Where	as	in	Group	B	11	patients	(55%)	cured	and	7	patients	(35%)	Partially	relieved.	Conclusion:	The	study	proved	eficacy	of	Unani	formulation	with	good	results	in	Benign	Endometrial	Hyperplasia	with	no	major	side	effects.