bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromosome-1 abnormalities in Childhood B-Lymphoblastic Leukemia – An analysis with reference to clinical variables and survival outcome
Authors: Mansoor Neelum , Rafiq Naila , Jamal Saba , Ehsan Aamir 
Published: December 2023

Background: Chromosome-1 abnormalities (C1As) are common genetic aberrations in hematological malignancies. We sought to evaluate significance of these abnormalities with reference to clinical characteristics and survival outcome in a pediatric B-Lymphoblastic Leukemia (B-ALL) cohort.
Methods: This is a retrospective study conducted in cytogenetic section of Indus Hospital and Health Network. Data was retrieved from October 2020 to July 2022 for childhood B-ALL cases exhibiting C1As. Chromosome analysis was performed on Cytovision MB8 using G-banded metaphases derived from unstimulated bone marrow culture. Results were recorded according to the International System for Human Cytogenetic Nomenclature (ISCN-2020). Data analyzed using SPSS, version 24.0.
Results: C1As were observed in 60/450 (13.3%) cases of B-ALL. Among C1As, 29 (48%) cases had t(1;19). There were 13 (45%) balanced and 16 (55%) unbalanced translocations. The aberrations without t(1;19) were seen in 31 (52%) cases including 1q duplication with hyperdiploidy in 14 (45%) cases. The median age for C1As with and without t(1;19) was eight years and six years while the median leukocyte count was 32 x 109/L vs. 17 x 109/L. Event-free survival (EFS) for cases with and without t(1;19) was 69% and 74.2% respectively.
Conclusion: Despite the fact that the t(1;19) positive group had a higher median age, a higher white cell count and more CNS positives, the difference in EFS is statistically insignificant when compared to the t(1;19) negative cases. Furthermore, we found a survival difference between balanced and unbalanced t(1;19) groups, which is statistically insignificant but warrants large-scale prospective studies for further understanding.
doi: https://doi.org/10.12669/pjms.40.2(ICON).8946
How to cite this: Mansoor N, Rafiq N, Jamal S, Ehsan A. Chromosome-1 abnormalities in Childhood B-Lymphoblastic Leukemia – An analysis with reference to clinical variables and survival outcome. Pak J Med Sci. 2024;40(2):S47-S52. doi: https://doi.org/10.12669/pjms.40.2(ICON).8946
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Arthroscopic findings after manipulation under anesthesia in idiopathic capsulitis of the shoulder: A prospective study
Authors: Mlv Sai Krishna , Mittal Ravi , Chauhan Nitin 
Published: December 2023

BACKGROUND
Manipulation under anesthesia (MUA) of the shoulder joint is a commonly used method for the treatment of adhesive capsulitis. Though it has been known to be associated with a variety of complications, there is a paucity of studies describing the arthroscopic findings after MUA.
AIM
To describe the arthroscopic findings in patients with idiopathic adhesive capsulitis of the shoulder after MUA.
METHODS
We recruited 28 patients with idiopathic adhesive capsulitis who underwent arthroscopic capsular release. Manipulation of the shoulder was performed under anesthesia in all of these patients before capsular release. Intra-articular findings were recorded during arthroscopic capsular release in these patients.
RESULTS
All patients showed the presence of synovitis. Twenty-seven patients showed tears in the capsule on the anterior aspect. One patient had an avulsion of the anterior rim of the glenoid and labrum following the manipulation. Four patients had partial rotator cuff tears, and one patient showed a superior labrum anterior posterior lesion, which was not diagnosed preoperatively on magnetic resonance imaging.
CONCLUSION
MUA leads to rupture of the capsule, which is the desired outcome. However, the site of rupture of the capsule is dependent on the maneuvers of MUA. In addition, partial tears of the rotator cuff and osteochondral fractures of the glenoid can also occur.
Adult localized Langerhans cell histiocytosis: A case report
Authors: Yang Pan-Pan , Hu Su-Ye , Chai Xu-Ya , Shi Xiao-Meng , Liu Li-Xia , Li Ling-E 
Published: December 2023

BACKGROUND
Langerhans cell histiocytosis (LCH) is a rare clonal proliferative disease of Langerhans cells with unknown pathogenesis. An increasing number of clinicians recognize that LCH has a wide clinical spectrum and a highly varied course. Adults rarely develop LCH. Here, we report a case of adult localized LCH.
CASE SUMMARY
A 32-year-old woman presented with plaques and ulcers on the vulva and crissum, accompanied by pain that persisted for more than one year. Physical examination revealed a red-infiltrating plaque with ulcerations and exudates in the vulva and crissum. Pathological examination revealed a diffuse infiltration of lymphocytes, eosinophilic granulocytes, and histiocytoid cells in the superficial dermis. Proliferative histiocytoid cells showed mild atypia, partly with kidney-shaped nuclei. Immunohistochemical examination showed that the histiocytoid cells were positive for S100 protein and CD1 and weakly positive for CD68 (20% +), with a Ki-67 index of 30%. Laboratory tests did not reveal any other systemic damage. The patient was diagnosed with adult localized LCH and was prescribed oral prednisone (20 mg) once daily. The skin lesions gradually improved and are still being followed-up.
CONCLUSION
Adult localized LCH is rare and must be differentiated from other common conditions.
Anti-glial fibrillary acidic protein antibody and anti-aquaporin-4 antibody double-positive neuromyelitis optica spectrum disorder: A case report
Authors: Jin Ting-Yu , Lin Bing-Tong , Dai Li-Jv , Lu Xia , Gao Han , Hu Jin 
Published: December 2023

BACKGROUND
A case of neuromyelitis optica spectrum disorder (NMOSD) with positive cerebrospinal fluid (CSF) anti-aquaporin-4 antibody (AQP4-IgG) and anti-glial fibrillary acidic protein IgG (GFAP-IgG) at the time of relapse was reported. The exact roles of GFAP-IgG in NMOSD are not fully understood and are the subject of ongoing research. This study revealed the possible connection between GFAP-IgG and the occurrence or development of diseases.
CASE SUMMARY
A 19-year-old woman was admitted to the hospital due to a constellation of symptoms, including dizziness, nausea, and vomiting that commenced 1 year prior, reoccurred 2 mo ago, and were accompanied by visual blurring that also began 2 mo ago. Additionally, she presented with slurred speech and ptosis, both of which emerged 1 mo ago. Notably, her symptoms deteriorated 10 d prior to admission, leading to the onset of arm and leg weakness. During hospitalization, magnetic resonance imaging showed high T2-fluid attenuated inversion recovery signals, and slightly high and equal diffusion-weighted imaging signals. The serum antibody of AQP4-IgG tested positive at a dilution of 1:100. CSF antibody testing showed positive results for GFAP-IgG at a dilution of 1:10 and AQP4-IgG at a dilution of 1:32. Based on these findings, the patient was diagnosed with NMOSD. She received intravenous methylprednisolone at a daily dose of 500 mg for 5 d, followed by a tapering-off period. Afterward, the rate of reduction was gradually slowed down and the timely use of immunosuppressants was implemented.
CONCLUSION
The CFS was slightly GFAP-IgG-positive during the relapse period, which can aid in the diagnosis and treatment of the disease.
Biomimetic vascularized adipose-derived mesenchymal stem cells bone-periosteum graft enhances angiogenesis and osteogenesis in a male rabbit spine fusion model
Authors: Fu Tsai-Sheng , Chen Wei-Chuan , Wang Ying-Chih , Chang Chia-Wei , Lin Tung-yi , Wong Chak-Bor 
Published: December 2023

AimsSeveral artificial bone grafts have been developed but fail to achieve anticipated osteogenesis due to their insufficient neovascularization capacity and periosteum support. This study aimed to develop a vascularized bone-periosteum construct (VBPC) to provide better angiogenesis and osteogenesis for bone regeneration.MethodsA total of 24 male New Zealand white rabbits were divided into four groups according to the experimental materials. Allogenic adipose-derived mesenchymal stem cells (AMSCs) were cultured and seeded evenly in the collagen/chitosan sheet to form cell sheet as periosteum. Simultaneously, allogenic AMSCs were seeded onto alginate beads and were cultured to differentiate to endothelial-like cells to form vascularized bone construct (VBC). The cell sheet was wrapped onto VBC to create a vascularized bone-periosteum construct (VBPC). Four different experimental materials – acellular construct, VBC, non-vascularized bone-periosteum construct, and VBPC – were then implanted in bilateral L4-L5 intertransverse space. At 12 weeks post-surgery, the bone-forming capacities were determined by CT, biomechanical testing, histology, and immunohistochemistry staining analyses.ResultsAt 12 weeks, the VBPC group significantly increased new bone formation volume compared with the other groups. Biomechanical testing demonstrated higher torque strength in the VBPC group. Notably, the haematoxylin and eosin, Masson’s trichrome, and immunohistochemistry-stained histological results revealed that VBPC promoted neovascularization and new bone formation in the spine fusion areas.ConclusionThe tissue-engineered VBPC showed great capability in promoting angiogenesis and osteogenesis in vivo. It may provide a novel approach to create a superior blood supply and nutritional environment to overcome the deficits of current artificial bone graft substitutes.Cite this article: Bone Joint Res 2023;12(12):722–733.
The modified Spitzy shelf acetabuloplasty for the dysplastic hip
Authors: Oe Kenichi , Iida Hirokazu , Otsuki Yosuke , Kobayashi Fumito , Sogawa Shohei , Nakamura Tomohisa , Saito Takanori 
Published: December 2023

AimsAlthough there are various pelvic osteotomies for acetabular dysplasia of the hip, shelf operations offer effective and minimally invasive osteotomy. Our study aimed to assess outcomes following modified Spitzy shelf acetabuloplasty.MethodsBetween November 2000 and December 2016, we retrospectively evaluated 144 consecutive hip procedures in 122 patients a minimum of five years after undergoing modified Spitzy shelf acetabuloplasty for acetabular dysplasia including osteoarthritis (OA). Our follow-up rate was 92%. The mean age at time of surgery was 37 years (13 to 58), with a mean follow-up of 11 years (5 to 21). Advanced OA (Tönnis grade ≥ 2) was present preoperatively in 16 hips (11%). The preoperative lateral centre-edge angle ranged from -28° to 25°. Survival was determined by Kaplan-Meier analysis, using conversions to total hip arthroplasty as the endpoint. Risk factors for joint space narrowing less than 2 mm were analyzed using a Cox proportional hazards model.ResultsThe mean Merle d'Aubigné clinical score improved from 11.6 points (6 to 17) preoperatively to 15.9 points (12 to 18) at the last follow-up. The survival rates were 95% (95% confidence interval (CI) 91 to 99) and 86% (95% CI 50 to 97) at ten and 15 years. Multivariate Cox regression identified three factors associated with radiological OA progression: age (hazard ratio (HR) 2.85, 95% CI 1.05 to 7.76; p = 0.0398), preoperative joint space (HR 2.41, 95% CI 1.35 to 4.29; p = 0.0029), and preoperative OA (HR 8.34, 95% CI 0.94 to 73.77; p = 0.0466).ConclusionModified Spitzy shelf acetabuloplasty is an effective joint-preserving surgery with a wide range of potential indications.Cite this article: Bone Jt Open 2023;4(12):932–941.
Trend and determinants of home delivery in Gambia, evidence from 2013 and 2020 Gambia Demographic and Health Survey: A multivariate decomposition analysis
Authors: Nigatu Solomon Gedlu 
Published: December 2023

Background
Home delivery is defined as is an even of pregnant women getting giving birth in a woman her home or other homes without an unskilled health professional assistance. It is continuing as public health problem since its responsible for death of women and newborn. In Gambia there is a high maternal mortality rate, which may be related to home delivery. Therefore, this study aimed to assess the trend of home delivery and identify predictors using Gambia Demographic and Health Survey (GDHS) 2013 and 2019–2020 data sets.

Methods
A Cross-Section survey was conducted based on GDHS 2013 and 2019–2020 among reproductive age group women. A total of 8607 women participated in this study. A bivariate decomposition model was fitted, and variables that had a p-value > 0.25 were dropped. Finally, variables that got a p-value of < 0.05 with 95% confidence interval (CI) in the multivariate decomposition analysis were considered as statistical significance variables in the overall decomposition.

Results
There has been a dramatic decrement in maternal home delivery in Gambia. It was 36.18% (95% CI:34.78, 37.58) in 2013 GDHS and 14.39% (95% CI:13.31,15.47) in 2019–2020 GDHS. This reduction is real because there was a change in the characteristics effect of the population and the coefficient effect some variables in the home delivery. Changes in characteristics effect of husband education, women education, rural residents, more than three antenatal cares follow up, and no problem reaching health facilities played a significant role in the reduction of home delivery. Being urban resident and women who had occupation were variables that had a positive effect on coefficient effect change.

Conclusion
In this study, the home delivery rate had steeply declined in the Gambia during the study period of the two surveys. Just above nine-tenths decrement in home delivery rate resulted because there was a change in the characteristics effect of the study participants. Enhancing more citizens to attend high school and above, narrowing the gap between rural and urban in terms of accessing health facilities, and improving the availability of infrastructure should be done.
Features of biology and population dynamics of Cephalanthera rubra (Orchidaceae Juss.) in the Sochi Black Sea region
Authors: Averyanova E. A. 
Published: December 2023

Cephalanthera rubra (L.) Rich. is sporadically distributed in the Sochi Black Sea region. It occurs in the forests of the low-mountain and mid-mountain belts of the southern macroslope of the Main Caucasian Range. The number of individual populations is from two-three to a dozen individuals, usually populations are distant from each other over long distances. C. rubra can be attributed to hemiephemeroids, having spring-early summer green shoots with a period of summer-autumn-winter dormancy. The growing season lasts 3 months. Morphometric indicators of individuals of different ontogenetic states are given. The dynamics of the ontogenetic structure of the population from the area of the hornbeam forest in the vicinity of the village Illarionovka for 8 years is shown. In the ontogenetic spectra of the studied large population, the predominance of generative individuals is constant. The population is full-membered, normal type, stable. The species is self-compatible, autogamy was not revealed. The model species for pollinators seems to be Lathyrus laxiflorus (Desf.) Kuntze, which is absent from the studied population. Fruit formation in different locations does not always occur; it is absent in the studied population. Seeds of Limodorum-type, linear or fusiform, about 1.3 mm long. The species is protected in the Sochi National Park and in the Khosta Department of the Caucasian State Natural Biosphere Reserve.
Analysis of habitats and bioecological composition of communities with the participation of species of the genus Delphinium in the southeast of European Russia
Authors: Bogoslov A. V. , Shilova I. V. , Kashin A. S , Parkhomenko A. S. , Grebenyuk L. V 
Published: December 2023

Between 2013 and 2020, 47 communities with seven species of the genus Delphinium were studied on the territory of 12 regions of the southeast of European Russia. The analysis of habitats by vegetation cover using the ecological scales of L. G. Ramensky showed that soils under communities with species of the genus Delpinium are often quite rich and very slightly alluvial.
D. subcuneatum communities grow in habitats with the highest moisture-meadow-steppe (moist-steppe) and wet-meadow habitats; communities of D. duhmbergii grow in less humid habitats with dry-meadow (and fresh-meadow) moisture; with dry-meadow (and fresh-meadow) and meadow-steppe (moist-steppe) humidification - communities of D. dictyocarpum, D. litwinowii, and
D. pubiflorum; in meadow-steppe (moist-steppe) humidification, communities of D. sergii. D. puniceum communities grow in the least moisture-provided habitats, with moisture ranging from dry-steppe and middle-steppe to semi-desert (desert-steppe). The biomorphological composition of communities with species of the genus Delphinium is dominated by hemicryptophytes, among which, the most numerous are tap-rooted, short-rhizomatous, and long-rhizomatous. The composition of cenomorphs reflects the confinement of communities with the majority of Delphinium species presented in the study to the forest-steppe zone, and communities with D. sergii and D. puniceum - to the steppe and semi-desert zone. In communities, the first place among trophomorphs is occupied by mesotrophs, and the second by megatrophs. The spectrum of hygromorphs is quite wide and includes species from xerophytes to ultrahygrophytes, however, xerophytes, mesoxerophytes, xeromesophytes, and mesophytes are the predominant groups most often. Judging by the predominance of heliophytes among heliomorphs, communities with all studied species of the genus Delphinium prefer open spaces. The spectrum of thermomorphs of all studied communities is dominated by mesotherms, for which the ecological optimum coincides with a moderate heat supply regime.
Phytocenotic characteristics and assessment of the state of the Elymus repens (L.) Gould (Poaceae) coenopopulation in the Southwestern Tien Shan
Authors: Saribaeva Sh. U. 
Published: December 2023

Four coenopopulations of Elymus repens L. Gould were studied in different ecological and coenotic conditions in the mountains of the Southwestern Tien Shan. It was revealed that under anthropogenic load (grazing) the ontogenetic spectrum changes and becomes bimodal. In undisturbed phytocenoses, a left-sided ontogenetic spectrum is observed. The density of individuals in the studied cenopopulations varied from 14.9 to 9.45 ind./m2, and the ecological density was 29.8-11.81 ind./m2. According to the “delta-omega” classification, the cenopopulations of Elymus repens CP 1,4 are maturing, CP 3 and 4 are young. Existing cenopopulations are mainly located in unprotected areas. The only solution to preserve cenopopulations can be strict protection of cenopopulations.
PROGRAMA AFROUNEB
Authors: Santos da Silva Luiz Gustavo 
Published: December 2023

O texto compõe um dos capítulos da tese[1] de doutorado “O que a gente não registra, o vento leva: diálogos com intelectuais negros(as) da Bahia”, defendida na Universidade do Estado do Rio de Janeiro. Contém reflexões sobre uma experiência no programa de formação de professores(as) AfroUneb, apresentando a sua proposta e desdobramentos. Afirma-se o método da história oral utilizado nas entrevistas com os(as) participantes da formação, possibilitando a ressignificação de memórias. Entende-se o AfroUneb como um “Movimento Negro Educador”, agente promotor da implementação da Lei 10.639/03 na Bahia.

[1]A pesquisa contou com o financiamento da Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) através do programa Bolsa Faperj Nota 10.
EDUCAÇÃO PARA A SEXUALIDADE EM CURSOS DE LICENCIATURA EM CIÊNCIAS BIOLÓGICAS
Authors: Wouters Emanuelly , Ferreira Acosta Daniele 
Published: December 2023

A presente pesquisa foi apresentada como Trabalho de Conclusão de Curso de Especialização em Educação para a Sexualidade: dos currículos escolares aos espaços educativos, da Universidade Federal do Rio Grande. O objetivo foi “analisar como os projetos pedagógicos e/ou as matrizes curriculares dos cursos de licenciatura em Ciências Biológicas das instituições federais do Rio Grande do Sul abordam a temática Educação para a Sexualidade”. A metodologia consistiu em uma análise documental dos projetos pedagógicos e/ou as matrizes curriculares dos cursos referidos. Os resultados apontaram que apenas uma instituição possui uma disciplina que estuda nomeadamente o tema, as demais articulam o tema a outras disciplinas; duas instituições não possuem disciplina que mencione a temática e uma instituição não possuía documentos disponíveis para análise. Acredita-se que os documentos precisam ser mais específicos, na tentativa de fortalecer e embasar os/as docentes formadores acerca da abordagem da Educação para a Sexualidade.
CORPO-AFETO E ANCESTRALIDADE NO PROCESSO EDUCATIVO DOS POVOS INDÍGENAS E QUILOMBOLAS:
Authors: Pinho Burlamaqui Ana Kerolaine , De Souza Aguiar José Vicente 
Published: December 2023

Este artigo é fruto de diálogos acerca dos saberes-vivências de docentes atuantes na Educação Indígena e na Educação Quilombola no contexto amazônico, cujo objetivo é compreender o que pode o corpo-afeto indígena e negro em processos educativos que considerem sua ancestralidade. A fundamentação teórica está embasada sob as vozes de autoras/es indígenas e negros em diálogo com Merleau-Ponty (1999), Spinoza (2009) e Ricoeur (1994), sob o aporte da fenomenologia-hermenêutica. Os resultados obtidos destacam a dissonância entre a legislação e a realidade vivenciada pelas escolas indígenas e quilombolas, o negligenciamento das corporeidades e de seus saberes, sobretudo, para que os dados possam ser articulados à Educação Escolar Indígena e Quilombola e a formação de professores.
PALAVRAS-CHAVE: Corpo-afeto. Ancestralidade. Educação Escolar Indígena. Educação Escolar Quilombola.
VIDAS QUEER NA ESCOLA
Authors: Dal'Igna Maria Cláudia , Sansone Ruan Carlos 
Published: December 2023

Neste artigo, são apresentados resultados de uma pesquisa de Trabalho de Conclusão de Curso em Pedagogia, articulados aos resultados de um Projeto de Pesquisa mais abrangente, desenvolvido em um Programa de Pós-Graduação em Educação da região sul do Brasil. O objetivo da primeira pesquisa é conhecer as trajetórias escolares de pessoas LGBTQIA+, analisando situações de discriminação, preconceito e violência sob a perspectiva de gênero e sexualidade. A segunda pesquisa descreve e analisa processos de generificação do trabalho docente e do currículo na educação básica e superior. As reflexões desenvolvidas neste artigo evidenciam os processos de naturalização do preconceito, LGBTfobia e demais violências, e as estratégias que as pessoas LGBTQIA+ criam para sobreviver na escola, e assim resistir e reexistir, criando outros modos de vida.
PALAVRAS-CHAVE: Violências. Resistências. Escola.
La nueva izquierda armada: un actor protagónico en la Argentina de los años ’70
Authors: Cormick Federico 
Published: December 2023

En este artículo se analiza un sector específico de la nueva izquierda argentina de las décadas de 1960 y 1970 conformado por las organizaciones armadas de la izquierda peronista y no peronista. Primero se realiza un estado de la cuestión sobre la nueva izquierda registrando el lugar otorgado a las experiencias armadas en las distintas interpretaciones y concluyendo con una propuesta de delimitación del campo. Luego, se analiza el desarrollo de la nueva izquierda armada: se delimitan sus características principales, se propone una periodización específica, y se analiza su creciente incidencia hacia la década del ’70, cuando desplegó un repertorio de acción que incluyó acciones armadas, intervención política no armada y movilización popular. El trabajo se basa en la bibliografía del tema y en fuentes escritas y orales de las organizaciones estudiadas.