bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Tantalum Oxide Nanopowder on Heat Cure Acrylic Resin Impact Strength and Surface Hardness
Authors: yaqoub yousif , Sajjad , Saleh Abdullah Zainab 
Published: October 2023

Background: In elderly patients, fracture of the denture is one of the most common problems. Therefore, in this research, a chemical tantalum oxide was added to test its effect on the extent of increasing the strength of the denture and its ability to withstand fracture.
Objective: To assess how Tantalum oxide affected heat – cured acrylic s impact strength and hardness.
Patients and Methods: The Intention was to create a total of (60) specimens. Twenty samples were made without additives (control), and 40 had made with tantalum oxide at two different amounts ( 1%, 1.5%).
Results: The impact strength tests showed highly significant difference among studied groups . The hardness test also showed really significant difference between the two groups, the controls and the experiments. when tantalum oxide had added the impact strength and hardness had increase in all concentration.
Conclusion: Denture fracture in elderly patients is the main problem, while when adding this substance, a decrease in the fracture rate was observed when compared with dentures without adding this substance.
Bocavirus and rotavirus co-infection in children with acute gastroenteritis and associated risk factors
Authors: Yaseen Mohammad, Mohammad , Mujahid Al-Shuwaikh , Arwa , Talib Al-Hamdani Haider 
Published: October 2023

Background: Both Viruses are the leading cause of acute gastroenteritis in infants and young children and are considered an important cause of mortality worldwide.
Objective: To estimate the rate of human bocavirus and rotavirus co-infection in children with acute gastroenteritis and determine any association with different risk factors.
Patients and Methods: Stool samples were collected from one hundred children suffering from acute gastroenteritis at the Central Teaching Hospital of Pediatrics, Baghdad, Iraq, for the period from December 2021 to April 2022. Samples were stored at -20 °C until they were utilized by PCR and ELISA to identify the human bocavirus (HBoV) DNA and rotavirus antigen (RV-Ag), respectively.
Results: This cross-sectional study showed that HBoV DNA was detected in 10 out of 100 samples (10%), while RV-Ag was detected in 22 out of 93 samples (23.66%), and the co-infection rate was 100% (All cases positive for HBoV were also positive for RV). None of the studied demographic data and risk factors showed a significant association with HBoV and/or rotavirus infection (P>0.05).
Conclusion: Most NICU deaths resulted from prematurity and respiratory distress syndrome. Enhancing healthcare personnel skills, standardizing protocols, and evidence-based practices for preterm and respiratory distress syndrome management can help reduce neonatal mortality rates in Iraq.
Role of CD68+ and CD206+ cells in the progression of toxic liver fibrosis in rats
Authors: Lebedeva E. I. , Shchastniy A. T. , Babenka A. S. 
Published: October 2023

The aim of the work was to evaluate the role of stellate macrophages in a large number of points of toxic liver fibrosis in rats. Liver fibrosis and cirrhosis in male Wistar rats were induced with thioacetamide at a dose of 200 mg/kg animal weight for 17 weeks. Histological preparations of the liver were stained with hematoxylin and eosin according to the Mallory method. Immunohistochemical examination was performed on paraffin sections using monoclonal mouse antibodies CD68 and polyclonal rabbit antibodies CD206. The fibrosis degree was determined according to the Ishak semi-quantitative scale. Toxic liver fibrosis before the start of its transformation into cirrhosis (9 weeks) was accompanied by an increase in the number of CD68+ cells compared with the control. At all subsequent experiment stages, no differences were found in comparison to the control. In the liver of control rats, CD206+ cells were practically absent. Throughout the experiment, their number remained above the control point – 3 weeks. With the progression of liver cirrhosis, a decrease in the number of CD206+ cells was noted, but it did not reach a level of 3 weeks. Morphologically, two different groups of CD68+ cells were identified. One group of cells had a pterygoid shape and they were located mainly in the liver sinusoids. The second group of CD68+ cells had a round shape and different localization. They were detected around the vessels of portal zones, surrounded brown pigment accumulations in connective tissue septa, were observed near single lying groups or groups of giant hepatocytes and liver cells containing brown pigment in the cytoplasm, and were also noted in the foci of necrosis of hepatocytes. Cells, expressing the CD206 marker, are round in shape and are elongated and located in the liver sinusoids. Presumably, round-shaped CD68+ cells perform a phagocytic function, and pterygoid-shaped CD68+ cells transdifferentiate into CD206+ cells that have anti-inflammatory properties.
Antioxidant activity of new varieties spicy-aromatic and essential-oil plants
Authors: Sachyuka T. U. , Kovalenko N. A. , Supichenko G. N. , Bosak V. M. 
Published: October 2023

Spicy-aromatic and essential-oil plants are among the most important food, technical and medicinal plants; their green mass, seeds and essential oils are used in various sectors of the economy. The purpose of the research was to study the indicators of antioxidant activity of the green mass of new varieties of spicy-aromatic and essential-oil plants. The research subjects were new regionalized varieties of oregano, hyssop officinalis, common basil, fine-flowered basil, fragrant onion, multi-tiered onion, fragrant rue, blue fenugreek, large-rhizome geranium and borage. The yield of green mass during flowering phase was studied in field experiments according to generally accepted methods. In laboratory experiments, the content of vitamin C and carotene was studied according to standard methods, content of polyphenolic compounds – according to method of calibration schedule based on a standard substance – rutin. As a result of field and laboratory studies, it has been determined that the yield of the green mass of the studied crops was 125–280 c/ha, vitamin C – 27.0–69.0 mg/100 g, carotene – 7.5–40.7 mg/kg, polyphenol compounds – 9.6–374.2 mg rutin/g. The studied spicy-aromatic and essential-oil plants in terms of antioxidant activity (content of polyphenol compounds) can be grouped into the following series: oregano > large-rhizome geranium > hyssop officinalis > basil > borage > fragrant rue > blue fenugreek > perennial onions. Among the varieties of oregano and hyssop, higher rates of antioxidant activity are noted in varieties with a more intense corolla color (rich pink – in oregano, blue – in hyssop). The results obtained on the yield of marketable products and antioxidant activity make it possible to more fully evaluate spicy-aromatic and essential-oil plants with the prospect of their use in various sectors of the economy, primarily in the development of functional products.
BUDIDAYA MASYARAKAT DALAM RANGKA PEMANFAATAN KOLAM TANAH BEKAS UNTUK PERIKANAN WARGA
Authors: Fitriana Nur , Wahid Riyan Falah Al 
Published: October 2023

Pengabdian ini bertujuan untuk Budidaya Masyarakat Dalam Rangka Pemanfaatan Kolam Tanah Bekas Untuk Perikanan Warga di Tuah Madani. Metode pengabdian yang digunakan adalah survei lapangan, observasi, wawancara, dan analisis data. Hasil pengabdian menunjukkan bahwa pemanfaatan kolam kelompok tani dalam budidaya ikan lele memiliki potensi yang signifikan dalam meningkatkan pendapatan masyarakat Tuah Madani. Partisipasi aktif kelompok tani, penggunaan teknik budidaya yang tepat, dan pengelolaan yang baik menjadi faktor kunci kesuksesan dalam proyek ini. Dalam jangka panjang, budidaya ikan lele di kolam kelompok tani dapat memberikan dampak positif terhadap ekonomi dan kesejahteraan masyarakat Tuah Madani, Pada kegiatan kali KKN Kelompok 18 mengadakan acara pelepasan bibit ikan lele sebagai bentuk ingin menumbuhkan rasa minat masyarakat dan kelompok budidaya ikan lele terhadap berpotensinya dalam pembudidayaan ikan lele ini sebagai sumber mata pencarian tambahan masyarakat tuah madani. Kegiatan ini yang menerapkan konsep budidaya ikan lele dengan memanfaatkan kolam kelompok tani budidaya ikan yang terbengkalai yang terletak di Jalan Kabun, Perum. Griya Firdaus Permai RT 01 / RW 08, Kecamatan Tuah madani , Kelurahan Tuahmadani. Kegiatan ini adalah salah satu bentuk dari program pengabdian kepada masyarakat. Konsep budidaya ikan lele ini dilakukan dengan cara memanfaatkan kolam kelompok tani budidaya ikan yang terbengkalai dikawasan tersebut. Dengan adanya kegiatan budidaya ikan lele ini diharapkan mampu menimbulkan rasa minat masyarakat dan kelompok budidaya ikan lele terhadap potensi besar dalam pembudidayaan ikan lele ini sebagai sumber mata pencarian tambahan masyarakat tuah madani
Effects of ventro-oral thalamic deep brain stimulation in a patient with musician’s dystonia: illustrative case
Authors: Poncelet Fauve , Smeets Sara , Taira Takaomi , Visser-Vandewalle Veerle , Vandenberghe Wim , Peeters Jana , Van Bogaert Tine , Nuttin Bart 
Published: October 2023

BACKGROUND
Musician’s dystonia is a task-specific focal hand dystonia characterized by involuntary contraction of muscles while playing a musical instrument. Current treatment options are often insufficient.

OBSERVATIONS
We present the effects of ventro-oral thalamic deep brain stimulation in a patient with musician’s dystonia. The patient was a 67-year-old pianist with musician’s dystonia who underwent deep brain stimulation with the ventralis oralis anterior and posterior nuclei of the thalamus as targets. The Tubiana and Chamagne rating scale was used to evaluate the effects of stimulation. The outcome was evaluated independently by four clinicians in a blinded manner at 3 months postoperatively. There was a distinct reduction of symptoms during stimulation. At 15 months postoperatively, the beneficial effect remained. No lasting side effects were observed.

LESSONS
Further studies are warranted to evaluate the safety and long-term efficacy of this treatment modality.
Awake resection of recurrent astroblastoma with intraoperative 5-ALA–induced fluorescence: illustrative case
Authors: Price Anthony , O’Leary Sean , Malkova Kseniia , D’Souza Preston , Ogasawara Christian , Felicella Michelle M , Karas Patrick J 
Published: October 2023

BACKGROUND
Astroblastoma is a rare neoplasm characterized as a circumscribed glial neoplasm most often arising in the frontoparietal cerebral hemispheres in older children.

OBSERVATIONS
We report an intriguing case of an astroblastoma recurrence 21 years after gross-total resection and radiation. A 32-year-old right-handed female presented to the emergency department for a generalized tonic-clonic seizure. She had a history of bipolar disorder, intractable migraines, and prior seizures linked to an astroblastoma previously resected three times. Magnetic resonance imaging on the current visit showed growth of the recurrent lesion to a 3.8-cm maximal diameter. Left-sided awake craniotomy was performed to remove the tumor while using speech mapping and 5-aminolevulinic acid (5-ALA). Targeted next-generation sequencing of the tumor revealed in-frame MN1::BEND2 fusion transcripts.

LESSONS
We found that 5-ALA can be used in astroblastoma patients to assist in gross-total resection, which is important for long-term survival. Our astroblastoma case demonstrated classic astroblastoma morphology, with typical perivascular astroblastic rosettes, and was brightly fluorescent after 5-ALA administration.
Relationship of Health Literacy and Social Support with Health-Promoting Behaviors in Women with Breast Cancer: Mediating Role of Cancer Self-Efficacy
Authors: Ameneh Etemadi Asl  , Sasan Bavi  , Johari Fard Reza 
Published: October 2023

Background: Women diagnosed with breast cancer experience high levels of psychological disorders ranging from depression, anxiety, maladjustment to the disease, and decreased self-confidence to different emotional disturbances and fears of recurrence and mortality. The present study aimed to investigate the mediating role of cancer self-efficacy in the relationship between health literacy and social support with health-promoting behaviors in women with breast cancer.
Methods: In this descriptive-correlational study, the convenience sampling method was employed to select 282 women diagnosed with breast cancer in Ahvaz, Khuzestan Province (Iran) in 2021. The participants were asked to answer the Health-Promoting Lifestyle Profile II (HPLP-II), Iranian Health Literacy Questionnaire, Social Support Survey, and Cancer Behavior Inventory. Path analysis was adopted to analyze data in AMOS software.
Results: The results revealed there was a significant relationship between perceived social support with health-promoting behaviors (P=0.004) and cancer self-efficacy (P=0.001) in women with breast cancer. There was a significant relationship between health literacy and cancer self-efficacy in women. According to the results, the mediating role of cancer self-efficacy in the relationship between perceived social support and health literacy with health-promoting behaviors was found to be significant in women with breast cancer (P=0.001).
Conclusion: Accordingly, the research model had a desirable fit. The findings of this research showed the effective role of cancer self-efficacy in the outcome of social support and health literacy to increase health-promoting behaviors in women with breast cancer.
ПУБЛІЧНО-ПРИВАТНЕ ПАРТНЕРСТВО У ПРОФЕСІЙНІЙ ОСВІТІ ЄВРОПЕЙСЬКИХ КРАЇН: ПРОВІДНІ ТЕНДЕНЦІЇ РОЗВИТКУ
Authors: Радкевич Валентина 
Published: October 2023

Актуальність статті зумовлена необхідністю виявлення та аналізу провідних тенденцій розвитку публічно-приватного партнерства у професійній освіті європейських країн для їх урахування в налагодженні державно-приватного партнерства в системі професійної освіти України.
Метою статті є виявлення й аналіз провідних тенденцій розвитку публічно-приватного партнерства у професійній освіті європейських країн; з’ясування можливостей їх урахування у вітчизняній практиці налагодження державно-приватного партнерства у сфері професійної освіти.
Методи: вивчення наукових джерел, законодавчих, нормативно-правових документів, емпіричних даних щодо публічно-приватного партнерства у професійній освіті – для виявлення його провідних тенденцій розвитку в європейських країнах; формування висновків і рекомендацій.
Результати: на основі аналізу сучасних законодавчих, нормативно-правових документів, наукових джерел, емпіричних даних виявлено та проаналізовано провідні тенденції розвитку публічно-приватного партнерства у професійній освіті європейських країн: розширення учасників партнерства і розвиток його нових форм; вплив партнерства на підвищення якості професійної освіти; розроблення спільно з партнерами навчальних програм відповідно до вимог ринку праці; збільшення обсягів фінансування професійної освіти шляхом інвестицій державного та приватного секторів, а також міжнародних організацій тощо.
Висновки: провідні тенденції розвитку ППП у професійній освіті європейських країн орієнтовані на: підвищення ефективності взаємодії між навчальними закладами, державними та приватними установами, громадськими, професійними й міжнародними організаціями; залучення малих, середніх і великих компаній до процесу розроблення нових кваліфікацій, стандартів, навчальних програм, впровадження інноваційних технологій професійного навчання; забезпечення рівного доступу до професійної освіти, робочих місць на ринку праці; збільшення фінансової підтримки навчальних закладів та підприємств, які здійснюють професійне навчання студентів тощо. Сформульовано пропозиції українським закладам професійної освіти для налагодження державно-приватного партнерства (ДПП), а саме: забезпечення ефективної комунікації між учасниками партнерства – для обміну досвідом і спільного використання ресурсів; визначення чітких умов, зобов’язань і ризиків між партнерами – для підвищення рівня їхньої відповідальності за якість реалізації проєктів ДПП; вдосконалення механізмів контролю та оцінювання результатів співпраці – для своєчасного коригування напрямів розвитку партнерства; збільшення обсягів фінансової підтримки проєктів ДПП – для забезпечення стабільного функціонування закладів професійної освіти на основі додаткових ресурсів; розширення участі громадськості в реалізації проєктів ДПП – для підвищення престижності професійної освіти та її впливу на відновлення України в повоєнний час тощо.
Transformation of Type I Fuzzy Logic into Interval Type II Fuzzy Logic-based Unit Voltage Template with Controlled Load
Authors: Drak Alsebai Muhannad , Pedapenki Kishore Kumar 
Published: October 2023

The interval type II fuzzy logic controller (IT2FL) is a recent artificial intelligent technology which is applied in many aspects of electrical power engineering and controlling strategies these days. The improving of Distribution Static Synchronous Compensator (DSTATCOM) control algorithms is still ongoing, because the control strategy of DSTATCOM device is considered as a decisive factor which affects the performance of DSTATCOM device in enhancing the quality of power in the distribution grids. The improving process focuses in two main aspects the DC capacitor voltage response to the control system and the mitigation of the harmonics which are produced by the controlled and uncontrolled rectified loads. In this paper, the interval type II fuzzy logic controller (IT2FL) based the Unit Voltage Template strategy (UVT) is examined by the MATLAB program with two different ranges of input signals, and compared with the type I Fuzzy logic controller (T1FL). The IT2FL based UVT shows promising results in improving the deformed shape of source current waves in comparison with the other controllers.
“Swamped with information”: a qualitative study of family physicians' experiences of managing and applying pandemic-related information
Authors: Young Gillian , Mathews Maria , Hedden Lindsay , Lukewich Julia , Marshall Emily Gard , Gill Paul , McKay Madeleine , Ryan Dana , Spencer Sarah , Buote Richard , Meredith Leslie , Moritz Lauren , Brown Judith B. , Christian Erin , Wong Eric 
Published: October 2023

IntroductionProviding family physicians (FPs) with the information they need is crucial for their participation in a coordinated pandemic or health emergency response, and to allow them to effectively run their practices. Most pandemic planning documents do not address communication plans specific to FPs. This study describes FPs' experiences and challenges with information management during the COVID-19 pandemic in Canada.MethodsWe conducted semi-structured qualitative interviews with FPs across four Canadian regions and asked about their roles during different pandemic stages, as well as facilitators and barriers they experienced in performing these roles. We transcribed the interviews, used a thematic analysis approach to develop a unified coding template across the four regions, and identified recurring themes.ResultsWe interviewed 68 FPs and identified two key themes specifically related to communication. The first is FPs' experiences obtaining and managing information during the COVID-19 pandemic. FPs were overwhelmed by the volume of information and had difficulty applying the information to their practices. The second is the specific attributes FPs need from the information sent to them. Participants wanted summarized and consistent information from credible sources that are relevant to primary care.DiscussionProviding clear, collated, and relevant information to FPs is essential during pandemics and other health emergencies. Future pandemic plans should integrate strategies to deliver information to FPs that is tailored to primary care. Findings highlight the need for a coordinated communication strategy to effectively inform FPs in health emergencies.
Serum cytokines and neutrophil-to-lymphocyte ratio as predictive biomarkers of benefit from PD-1 inhibitors in gastric cancer
Authors: Hou Yidan , Li Xiaoli , Yang Yudan , Shi Hao , Wang Shaofang , Gao Ming 
Published: October 2023

BackgroundImmunotherapy is significantly revolutionizing cancer treatment and demonstrating promising efficacy in gastric cancer (GC) patients. However, only a subset of patients could derive benefits from targeted monoclonal antibody therapy against programmed death receptor 1 (PD-1). This study aims to identify suitable serum cytokines and blood cell ratios as predictive biomarkers to aid in the selection of GC patients likely to benefit from PD-1 inhibitors.Materials and methodsThis retrospective study included 41 GC patients who received PD-1 inhibitors combined with chemotherapy, 36 GC patients treated solely with chemotherapy, and 33 healthy controls. The study assessed the levels of seven cytokines: interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and various inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), total lymphocyte count (TLC), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR). Measurements were obtained using the inpatient system. Univariate and multivariate Cox regression analyses were performed to evaluate the predictive significance of these hematologic parameters for clinical outcomes.ResultsLevels of IL-6, IL-10, TNF-α, NLR, and PLR were significantly elevated in GC patients compared to healthy controls, while TLC and LMR were higher in the control group. Among the 41 patients receiving PD-1 inhibitors and chemotherapy, baseline IL-2 was associated with OS and PFS. Additionally, IL-6 and IL-17A correlated with OS, while NLR was linked to PFS (all P&lt;0.05). These factors were identified as independent prognostic indicators in both univariate and multivariate analyses. Furthermore, almost all cytokine levels increased following the initiation of PD-1 inhibitor treatment.ConclusionsThe introduction of PD-1 inhibitors alongside chemotherapy in GC impacts serum cytokine levels. IL-2, IL-6, IL-17A, and NLR exhibit potential as reliable circulating predictive biomarkers for identifying patients who may benefit from PD-1 inhibitors combined with chemotherapy.
Causal influences of osteoarthritis on COVID-19: a Mendelian randomization study
Authors: Fu Li , Baranova Ancha , Cao Hongbao , Zhang Fuquan 
Published: October 2023

ObjectiveAlthough observational and genetic studies have indicated a correlation between OA and COVID-19, it remains uncertain whether osteoarthritis (OA) contributes to the severity of COVID-19. Here, we aimed to investigate the potential causal links between the two.MethodsIn this study, we conducted Mendelian randomization (MR) analysis to investigate whether there is a potential causal connection between OA and COVID-19 outcomes. The analysis utilized publicly available GWAS summary datasets, incorporating data on OA (N = 455,221), SARS-CoV-2 infection (N = 2,597,856), hospitalized COVID-19 (N = 2,095,324), and critical COVID-19 (N = 1,086,211). Additionally, we performed a literature analysis to establish a molecular network connecting OA and COVID-19.ResultsThe MR analysis showed causal effects of OA on hospitalized COVID-19 (OR: 1.21, 95% CI: 1.02–1.43, p = 0.026) and critical COVID-19 (OR: 1.35, 95% CI: 1.09–1.68, p = 0.006) but not on SARS-CoV-2 infection as such (OR: 1.00, 95% CI: 0.92–1.08, p = 0.969). Moreover, the literature-based pathway analysis uncovered a set of specific genes, such as CALCA, ACE, SIRT1, TNF, IL6, CCL2, and others, that were found to mediate the association between OA and COVID-19.ConclusionOur findings indicate that OA elevates the risk of severe COVID-19. Therefore, larger efforts should be made in the prevention of COVID-19 in OA patients.