bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric validation of the Ostomy Skin Tool 2.0
Authors: Jemec Gregor , Herschend Nana Overgaard , Hansen Helle Doré , Findley Amy , Williams Abi , Sully Kate , Karlsmark Tonny , Størling Zenia 
Published: December 2023

Background
Peristomal skin complications (PSCs) pose a major challenge for people living with an ostomy. To avoid severe PSCs, it is important that people with an ostomy check their peristomal skin condition on a regular basis and seek professional help when needed.

Aim
To validate a new ostomy skin tool (OST 2.0) that will make regular assessment of the peristomal skin easier.

Methods
Seventy subjects participating in a clinical trial were eligible for the analysis and data used for the validation. Item-level correlation with anchors, inter-item correlations, convergent validity of domains, test-retest reliability, anchor- and distribution-based methods for assessment of meaningful change were all part of the psychometric validation of the tool.

Results
A final tool was established including six patient reported outcome items and automatic assessment of the discolored peristomal area. Follow-up with cognitive debriefing interviews assured that the concepts were considered relevant for people with an ostomy.

Conclusion
The OST 2.0 demonstrated evidence supporting its reliability and validity as an outcome measure to capture both visible and non-visible peristomal skin complications.
Local Treatment and Treatment-Related Adverse Effects Among Patients With Advanced Prostate Cancer
Authors: Khan Saira , Chang Su-Hsin , Wang Mei , Kim Eric H. , Schoen Martin W. , Rocuskie-Marker Carleena , Drake Bettina F. 
Published: December 2023

ImportanceRecent data suggest that local treatment with radical prostatectomy or radiation may improve survival outcomes in men with advanced prostate cancer. However, evidence is lacking on treatment-related adverse effects among men with advanced prostate cancer.ObjectiveTo assess the association of local treatment on treatment-related adverse effects among men diagnosed with advanced prostate cancer.Design, Setting, and ParticipantsThis cohort study assessed men diagnosed with advanced prostate cancer (defined as T4, N1, and/or M1 prostate cancer) between January 1, 1999, and December 31, 2013, with follow-up through December 31, 2021, who were treated at Veterans Health Administration medical centers.ExposureLocal treatment with radical prostatectomy or radiation.Main Outcomes and MeasuresMain outcomes were treatment-related adverse effects, including constitutional, gastrointestinal, pain, sexual function, and urinary function conditions, at 3 intervals after initial treatment (≤1 year, &amp;gt;1 to ≤2 years, and &amp;gt;2 to ≤5 years) after initial treatment.ResultsThis cohort study consisted of 5502 men (mean [SD] age, 68.7 [10.3] years) diagnosed with advanced prostate cancer. Of the cohort, 1705 men (31.0%) received local treatment. There was a high prevalence of adverse conditions in men receiving both local and nonlocal treatment, and these adverse conditions persisted for more than 2 years to 5 years or less after initial treatment. A total of 916 men (75.2%) with initial local treatment and 897 men (67.1%) with initial nonlocal treatment reported the presence of at least 1 adverse condition for more than 2 years to 5 years or less after initial treatment. In the first year, local treatment (vs nonlocal) was associated with adverse gastrointestinal (multivariable-adjusted odds ratio [AOR], 4.08; 95% CI, 3.06-5.45), pain (AOR, 1.57; 95% CI, 1.35-1.83), sexual (AOR, 2.96; 95% CI, 2.42-3.62), and urinary (AOR, 2.25; 95% CI, 1.90-2.66) conditions. Local treatment (without secondary treatment) remained significantly associated with adverse gastrointestinal (AOR, 2.39; 95% CI, 1.52-3.77), sexual (AOR, 3.36; 95% CI, 2.56-4.41), and urinary (AOR, 1.39; 95% CI, 1.09-1.78) conditions at more than 2 years to 5 years or less after treatment.Conclusions and RelevanceIn this cohort study of men with advanced prostate cancer, local treatment was associated with persistent treatment-related adverse effects across multiple domains. These results suggest that patients and clinicians should consider the adverse effects of local treatment when making treatment decisions in the setting of advanced prostate cancer.
Supporting method of compact city planning in local metropolitan areas across prefectural borders
Authors: Yoshida Yukino , Ikaruga Shinji , Kobayashi Takeshi , Shiraishi Rei 
Published: December 2023

AbstractThis study examines and visualizes a future urban structure of local metropolitan areas that extend over prefectural borders as in the case of Sinjiko‐nakaumi metropolitan areas located across Tottori prefecture and Shimane prefecture. First, we constructed an expert system based on prefectural and city administrative plans in the metropolitan urban area, showing a compact city model (Scenario 1). Second, we developed a compact city model to reflect potential development、 taking into account agricultural land conversions (Scenario 2). By comparing the results of these scenarios, we found that it is possible to visualize an intensive urban structure that takes into account the possibility of urban sprawl given that the conversion of agricultural land in suburban areas is only allowed at a certain level of development. Additionally, we identified inadequacies in existing compact‐city construction plans. To plan an effective urban structure for metropolitan areas situated on prefectural borders, it is important to emphasize the necessity of collaboration between municipalities in developing master plans for urban planning in areas located at or near borders. It is also necessary to review and redesign municipal master plans to ensure mutually convenient locations for facilities near borders and to regulate development in suburban areas.
A Multi‐Module Sensing and Bi‐Directional HMI Integrating Interaction, Recognition, and Feedback for Intelligent Robots
Authors: Fang Ping , Zhu Ming‐lu , Zeng Zhang‐bing , Lu Wen‐xiao , Wang Feng‐Xia , Zhang Lu , Chen Tao , Sun Li‐ning 
Published: December 2023

AbstractRapid advances in robotics have placed urgent demands on more intelligent human‐machine interaction technologies. Specifically, the way of establishing dual‐way intuitive communication with a consistent sensory system can greatly enhance efficiency and reliability. Here, a bi‐directional human‐machine interface (HMI) is designed by applying starch‐based hydrogel sensors. The whole system consists of a multi‐modal wearable sensory exoskeleton with a haptic feedback module and sensory robotic hand. The sensory exoskeleton with strain‐sensing glove and rotation‐sensing arm can capture and project the motion of the entire upper limb. The system offers object recognition functions by utilizing a sensing array on the robotic hands and machine learning algorithms, which can identify the shape and hardness information. The recognized results can be delivered back to the operator via vision and vibrational haptic feedback, respectively. This dual‐way intelligent sensory system shows potential application in many key fields such as the Internet of Things, teleoperation, and medical robotics.
Dynamic Polyimide Dielectric Film: A Concept and Application Perspective
Authors: Wan Baoquan , Zha Jun‐Wei 
Published: December 2023

AbstractPolyimide (PI) has excellent resistance to high or low temperatures due to its unique molecular structure, and is widely used in advanced electronics and power systems in extreme environments. In recent years, a small amount of studies have been published to modulate the dynamic behavior of PI such as self‐healable, recyclable, and degradable abilities by adjusting the structure of molecular chains and the composition of monomers. However, the conceptual design, formation conditions, and application prospects of dynamic PI are still unclear. In this paper, the new concepts and systems of dynamic PI are introduced from the perspective of the design of molecular structure, the development of regulating performance area, and the application of extreme insulation, based on recent work and other representative work. Specifically, this work appeals to researchers involved in PI synthesis, smart, dielectric, energy storage, and extreme insulation.
Perovskite‐Based Indoor Photovoltaics and their Competitors
Authors: Dou Da , Sun Haoxuan , Li Chen , Gan Shan , Li Liang 
Published: December 2023

AbstractModern electronics face formidable challenges in energy efficiency and durability. Owing to their safety, lightweight design, and simplicity, indoor photovoltaics (IPVs) have garnered substantial attention among various sustainable power sources. Remarkable progress is made in IPVs, achieving power conversion efficiencies (PCEs) ranging from 3.6% using silicon materials in 2011 to an impressive 42.43% using current perovskite materials. Although numerous summaries exist, most reviews of IPVs have narrowly focused on single active materials and lack a systematic overview across different material categories starting from fundamental design principles. This comprehensive review addresses this knowledge gap by introducing IPVs fabricated based on silicon, dye, III‐V, organic, and perovskite materials, compares the PCEs of these devices for indoor applications, and provides an overview of the advantages and disadvantages associated with the different materials. For the most promising materials, optimization and modification schemes are presented for perovskite‐based IPVs. The standardized testing of IPVs and urgent challenges encountered in their development are emphasized. This review offers valuable guidance for material selection and device design for future IPVs to facilitate PCE improvement and challenge resolution in the field of IPVs.
A 4D Printed Adhesive, Thermo‐Contractile, and Degradable Hydrogel for Diabetic Wound Healing
Authors: Lu Zhe , Cui Jingjing , Liu Fukang , Liang Chen , Feng Shiwei , Sun Yongding , Gao Weizi , Guo Yunlong , Zhang Biao , Huang Wei 
Published: December 2023

AbstractChronic wound healing remains a substantial clinical challenge. Current treatments are often either prohibitively expensive or insufficient in meeting the various requirements needed for effective diabetic wound healing. A 4D printing multifunctional hydrogel dressing is reported here, which aligns perfectly with wounds owning various complex shapes and depths, promoting both wound closure and tissue regeneration. The hydrogel is prepared via digital light process (DLP) 3D printing of the mixture containing N‐isopropylacrylamide (NIPAm), curcumin‐loaded Pluronic F127 micelles (Cur‐PF127), and poly(ethylene glycol) diacrylate‐dopamine (PEGDA575‐Do), a degradable crosslinker. The use of PEGDA575‐Do ensures tissue adhesion and degradability, and cur‐PF127 serves as an antibacterial agent. Moreover, the thermo‐responsive mainchains (i.e., polymerized NIPAm) enables the activation of wound contraction by body temperature. The features of the prepared hydrogel, including robust tissue adhesion, temperature‐responsive contraction, effective hemostasis, spectral antibacterial, biocompatibility, biodegradability, and inflammation regulation, contribute to accelerating diabetic wound healing in Methicillin‐resistant Staphylococcus aureus (MRSA)‐infected full‐thickness skin defect diabetic rat models and liver injury mouse models, highlighting the potential of this customizable, mechanobiological, and inflammation‐regulatory dressing to expedite wound healing in various clinical settings.
Design Criteria for Nanostructured Carbon Materials as Solid Contacts for Ion‐Selective Sensors
Authors: Chipangura Yevedzo E. , Spindler Brian D. , Bühlmann Philippe , Stein Andreas 
Published: December 2023

AbstractThe ability to miniaturize ion‐selective sensors that enable microsensor arrays and wearable sensor patches for ion detection in environmental or biological samples requires all‐solid‐state sensors with solid contacts for transduction of an ion activity into an electrical signal. Nanostructured carbon materials function as effective solid contacts for this purpose. They can also contribute to improved potential signal stability, reducing the need for frequent sensor calibration. In this Perspective, the structural features of various carbon‐based solid contacts described in the literature and their respective abilities to reduce potential drift during long‐term, continuous measurements are compared. These carbon materials include nanoporous carbons with various architectures, carbon nanotubes, carbon black, graphene, and graphite‐based solid contacts. The effects of accessibility of ionophores, ionic sites, and other components of an ion‐selective membrane to the internal or external carbon surfaces are discussed, because this impacts double‐layer capacitance and potential drift. The effects of carbon composition on water‐layer formation are also considered, which is another contributor to potential drift during long‐term measurements. Recommendations regarding the selection of solid contacts and considerations for their characterization and testing in solid‐contact ion‐selective electrodes are provided.
Roll‐to‐Roll Fabrication of Bijels via Solvent Transfer Induced Phase Separation (R2R‐STrIPS)
Authors: Siegel Henrik , de Ruiter Mariska , Athanasiou Georgios , Hesseling Cos M. , Haase Martin F. 
Published: December 2023

AbstractBicontinuous interfacially jammed emulsion gels (bijels) are soft materials with applications in separation science, energy storage, catalysis, and tissue engineering. Bijels are formed by arresting the liquid–liquid phase separation of two immiscible liquids via interfacial jamming of colloidal particles. Current fabrication methods of bijels employ either batch processing or continuous‐flow microfluidic synthesis. Production methods with higher throughput are needed to facilitate large‐scale synthesis of bijels. Herein, it is shown that roll‐to‐roll processing (R2R) enables the fabrication of bijel films with controlled dimensions at rates of several cm3 per minute. Increasing the bijel production rate via R2R requires an understanding of the interaction of the bijel with the R2R substrate. The study demonstrates that controlling the wetting on the R2R substrate enables the synthesis of uniform bijel films with adjustable thickness. Moreover, this research shows that the bijel film microstructure depends on the mechanism of phase separation and particle surface functionalization. The resulting knowledge gains can help to leverage bijel synthesis from laboratory to industrial scales in the future, promoting the exciting application potentials of bijels.
RNA‐on‐Nanowire: A Metallic Nanowire Biosensor for Ultrasensitive MiRNA Detection at Single‐Nucleotide Resolution
Authors: Sun Kai , Wang Xueqi , Zhang Junfeng , Cheng Jing , Wang Han 
Published: December 2023

AbstractMicroRNAs (miRNAs) are vital in regulating biological processes and serve as effective biomarkers for tumor diagnosis in clinical trials. However, current miRNA detection approaches either lack sensitivity and selectivity among similar sequences in complex biofluids, or require cumbersome instruments and tedious operations, making convenient miRNA testing challenging, especially in the field of point‐of care clinical diagnosis. Here, an ultrasensitive single metallic nanowire‐based biosensor with stem‐loop probes modified by redox substances for one‐step miRNA detection with single base detection resolution (RNA‐on‐Nanowire) is presented. Using miRNA‐16 as a proof‐of‐concept, the developed RNA‐on‐Nanowire biosensor demonstrates high sensitivity with a wide detection range of 10 am–1 pm and a low limit of detection (LOD) of 0.54 am in mock samples. Furthermore, the biosensor shows excellent selectivity to miRNA‐16 among various miRNAs with the detection capability of single base substitution. Moreover, the successful detection of miRNA in serum samples with an LOD of 0.89 am suggest the great potential of the RNA‐on‐Nanowire biosensor for clinical applications. Overall, the presented RNA‐on‐Nanowire biosensor holds advantages in small sample consumption, high sensitivity, high specificity, and excellent portability which provides a promising strategy to meet the point‐of‐care testing demand for diagnosis and prognosis of various genetic diseases.
Net Gain at the Near‐Infrared from CsPbBr3 Quantum Dots Sensitized Nd3+‐activated Tellurite Glass Under Solar Excitation
Authors: Niu Luyue , Liu Chuang , Zhang Kun , Wang Ci , Liu Lu , Chu Yushi , Ren Jing , Zhang Jianzhong 
Published: December 2023

AbstractLanthanide ions (Ln3+) doped near‐infrared (NIR) phosphors play a critical role in applications requiring a compact, reliable, and economical NIR light source, but as yet they suffer from weak and narrow‐band absorption because of intrinsic photophysical limitations of Ln3+. Here, CsPbBr3 perovskite quantum dots (PQDs) and Nd3+ co‐doped tellurite glassy phosphor is designed to significantly upgrade the NIR photoluminescence (PL) efficiency of Ln3+. Benefiting from the sensitization effect of the PQDs on Nd3+, the PL excitation band of Nd3+ is greatly extended, permitting far more excitation channels that are impossible for conventional Nd3+‐doped glass phosphors. Such glassy phosphors also show a good stability, and when coupled with a commercial UV (or blue) chip, a compact and low‐cost NIR phosphor‐converted LED (pc‐LED) is constructed with a photoelectric conversion efficiency of 2.25% and an output power of 2.55 mW. A proof‐of‐concept demonstration for night vision application is given using the NIR pc‐LED. The excellent overlap with the solar spectrum in the visible portion inspires us to explore the possibility of sunlight excitation, and a net gain of ≈5 dB cm−1 is obtained near the 1064 nm. The implications of the present study are enormous considering diverse combinations of PQDs and Ln3+ in GCs.
A Grafted Hybrid Nanosheet Array Architecture Enables Efficient Bifunctional Oxygen Catalytic Electrodes for Rechargeable Lithium−Oxygen Batteries
Authors: Li Ming , Li Erwei , Yi Jingyu , Xiao Liang , Liu Jinping 
Published: December 2023

AbstractTo fully manifest the high energy densities of lithium−oxygen (Li−O2) batteries, bifunctional catalytic cathodes that efficiently facilitate both the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) are mandatorily required. However, catalysts with intrinsic bifunctional catalytic activities are limited in practice. In addition, the practical utilization rate of oxygen catalytic cathodes is usually lower due to the deposition of insoluble discharge product Li2O2. To address these issues, this work proposes a grafted hybrid nanosheet array architecture to enable efficient bifunctional oxygen catalytic cathodes for Li−O2 batteries. As a demonstration, Co3O4 nanosheet arrays (MnO2−Co3O4@CC) grafted with MnO2 nanosheets are prepared on carbon cloth by facile electrodeposition followed by calcination in air. The mutually perpendicular Co3O4 and MnO2 nanosheets in the grafted architecture enable both the ORR catalytically active site of MnO2 and the OER catalytically active site of Co3O4 easily accessible during repeated cycling. Thus, the synergistic bifunctional catalysis of hybrid MnO2−Co3O4@CC is effectively realized to deliver a high specific capacity of 8115 mA h g−1 and a low overall overpotential of 0.64 V. This work provides a universal and effective approach for fabricating various efficient catalytic electrodes via the facile integration of different nanomaterials on nanoarray architectures.
Engineering Living Immunotherapeutic Agents for Improved Cancer Treatment
Authors: Gwisai Tinotenda , Günther Sina , Mirkhani Nima , Vizovisek Matej , Menghini Stefano , Jacobs Mira , Christiansen Michael G. , Oberhuber Ines , Poc Pascal , Schuerle Simone 
Published: December 2023

AbstractBacteria‐based agents are emerging as promising tools for cancer therapy due to their ability to actively target tumors, trigger localized inflammation, and induce tumor regression. There has been growing interest in using bacteria that are responsive to external cues, such as magnetic fields, to facilitate the formation of robust colonies in tumors and achieve the threshold for clinical efficacy. Several studies have demonstrated the potential of innately magnetically responsive bacteria, known as magnetotactic bacteria (MTB), as steerable agents. However, their immunostimulatory properties, which play a central role in their function as therapeutic agents, have not yet been adequately studied. Here, key aspects of human immune cell response to MTB strainMagnetospirillum magneticumAMB‐1 in physiological environments are characterized. The ability of MTB to maintain magnetic properties, remain viable in whole blood, elicit cytokine production by macrophages, and stimulate uptake of cancer cell material by dendritic cells is examined. This study also investigates the use of MTB–liposome complexes for effective delivery of therapeutic payloads in vitro and explores response to the agent in vivo. Overall, this work establishes the potential of MTB as a versatile, combined delivery platform for immune‐mediated cancer therapy.
Porphyrin‐Based Nanozymes for Biomedical Applications
Authors: Cheng Erli , Li Bowen , Zou Qianli 
Published: December 2023

AbstractPorphyrins are a class of heterocyclic compounds with a tetrapyrrole conjugated structure, having unique physical, chemical, and optical properties. They have garnered significant interest as building blocks for fabricating nanomaterials due to their attractive features. Porphyrins also serve as the catalytic activity centers for various biological enzymes, making them promising functional molecules for constructing artificial enzymes known as nanozymes. Despite this, the emerging field of porphyrin‐based nanozymes still lacks a comprehensive summary. Here, this study aims to provide a comprehensive overview of porphyrin‐based nanozymes that are engineered with varying methods and materials. In addition, the latest researches are highlighted on their biomedical applications, including cancer treatment, biosensing, antibacterial, and antioxidant applications. The focus lies in the supramolecular mechanisms underlying the nanoengineering approaches and catalytic functions of these nanozymes. The challenges and prospects of constructing porphyrin‐based nanozymes to promote their biomedical applications and the development of next‐generation nanomedicines are also discussed.
Low‐Cost, Compact Quadrupole Mass Filters with Unity Mass Resolution via Ceramic Resin Vat Photopolymerization
Authors: Eckhoff Colin C. , Lubinsky Nicholas K. , Metzler Luke J. , Pedder Randall E. , Velásquez‐García Luis F. 
Published: December 2023

AbstractThis study reports novel, compact, and additively manufactured quadrupole mass filters (QMFs) with adequate filtering performance for practical mass spectrometry applications. The QMFs are monolithically fabricated via vat photopolymerization of glass‐ceramic resin using 57 µm × 57 µm × 100 µm voxels, and selective electroless plating of nickel‐boron. Experimental characterization of QMF prototypes at 1.74 MHz using FC‐43 yields 131 Da peaks with 0.50 Da full width at half maximum (260 resolution), surpassing the resolution of reported miniaturized counterparts under similar conditions, and being on par with commercial, non‐miniaturized, heavier devices. The sensitivity of the 3D‐printed devices is estimated at 0.13 mA Torr−1(comparable to that of optimized, commercial counterparts), while the devices attained up to 250 Da of mass range (limited by the driving electronics). The work is of interest to low‐cost, capable mass spectrometry, 3D‐printed instruments, and in‐space manufacturing of complex instrumentation.