bluuebunny/crossref_metadata_2025_split huggingface dataset:
Satellite Multi‐Angle Observations of Wildfire Smoke Plumes During the CalFiDE Field Campaign: Aerosol Plume Heights, Particle Property Evolution, and Aging Timescales
Authors: Noyes K. T. Junghenn , Kahn R. A. 
Published: February 2024

AbstractWildfire‐related aircraft field campaigns frequently offer opportunities to validate remote‐sensing retrievals of aerosol properties and other quantities derived from satellite‐borne‐instrument observations. Satellite instruments often provide regional context‐imagery for more sparsely sampled aircraft and surface‐based measurements. However, aerosol amount, particle type, aerosol plume height and the associated wind vector products retrieved from the NASA Earth Observing System's Multi‐angle Imaging SpectroRadiometer (MISR) instrument have matured sufficiently that these quantities can also contribute substantially to a campaign data set, in regional context. This is especially useful when such measurements are not acquired at all from the suborbital platforms. During NOAA's California Fire Dynamics Experiment (CalFiDE), aircraft operations were coordinated with MISR overpasses on two occasions: for the Rum Creek fire on 30 August 2022, and for the Mosquito fire on 08 September. MISR‐retrieved aerosol properties show distinctly different patterns of black and brown smoke particle distributions and inferred plume evolution in the two cases. This paper presents the satellite‐retrieved results that complement the field observations, demonstrating what such measurements can offer, and contributing material for detailed fire dynamics and chemistry studies when combined with the CalFiDE suborbital observations and models in continuing studies.
Impact of Nitrate and Iron Ions on Uptake Coefficients and Condensed Phase Products From the Reaction of Gaseous NO2 With HULIS Proxies
Authors: Li Pan , Mekic Majda , Wang Yiqun , He Bowen , Deng Huifan , Xu Jinli , Pang Hongwei , Jiang Bin , Tang Mingjin , Wang Xinming , Al‐Abadleh Hind A. , Gligorovski Sasho 
Published: February 2024

AbstractHumic‐like substances (HULIS) are a ubiquitous reactive component of atmospheric aerosol. They participate in the formation of secondary organic aerosols via chemical reactions with atmospheric oxidants. Here, we assess the influence of transition metal ions (namely ferric iron, Fe(III)), and nitrate ions () on the heterogeneous reaction of gaseous NO2 with an aqueous film containing gallic acid (GA) or tannic acid (TA) as proxies for HULIS. Using a vertical wetted wall flow tube technique, the uptake coefficients of gaseous NO2 on GA and TA increased nonlinearly with increasing [Fe(III)], in dark and under light irradiation. However, the combined effect of both ions, Fe(III) and , led to a substantial decrease in NO2 uptake in the dark and under simulated near‐UV sunlight irradiation (300 < λ < 400 nm). The lifetime of GA in dilute aqueous phase, which corresponds to cloud water, due to reaction with NO2 would be 6 hr during both nighttime and daytime. However, the lifetime of GA in aerosol particles which contain both ions, that is, Fe(III) and , would increase to 27 hr during nighttime and 11 days and 6 hr due to light‐induced reaction with NO2. Also, we observed, using Fourier transform ion cyclotron resonance mass spectrometry, the formation of nitrocatechols compounds (e.g., methyl‐nitrocatechol), which contribute to brown carbon. Compounds with reduced functional groups such as amines were also observed in the presence of iron and nitrate ions in the dark and under irradiation, indicating that Fe(III) and , can influence the kinetics and product distribution in deliquescent aerosol particles.
Investigating Thermal Contrasts Between Jupiter's Belts, Zones, and Polar Vortices With VLT/VISIR
Authors: Bardet Deborah , Donnelly Padraig T. , Fletcher Leigh N. , Antuñano Arrate , Roman Michael T. , Sinclair James A. , Orton Glenn S. , Tao Chihiro , Rogers John H. , Melin Henrik , Harkett Jake 
Published: February 2024

AbstractUsing images at multiple mid‐infrared wavelengths, acquired in 2018 May using the Very Large Telescope Imager and Spectrometer (VISIR) instrument on ESO's Very Large Telescope (VLT), we study Jupiter's pole‐to‐pole thermal, chemical and aerosol structure in the troposphere and stratosphere. We confirm that the pattern of cool and cloudy anticyclonic zones and warm cloud‐free cyclonic belts persists throughout the mid‐latitudes, up to the polar boundaries, and evidence a strong correlation with the vertical maximum windshear and the locations of Jupiter's zonal jets. At high latitudes, VISIR images reveal a large region of mid‐infrared cooling poleward ∼64°N and ∼67°S extending from the upper troposphere to the stratosphere, co‐located with the reflective aerosols observed by JunoCam, and suggesting that aerosols play a key role in the radiative cooling at the poles. Comparison of zonal‐mean thermal properties and high‐resolution visible imaging from Juno allows us to study the variability of atmospheric properties as a function of altitude and jet boundaries, particularly in the cold southern polar vortex. However, the southern stratospheric polar vortex is partly masked by a warm mid‐infrared signature of the aurora. Co‐located with the southern main auroral oval, this warming results from the auroral precipitation and/or joule heating which heat the atmosphere and thus cause a significant stratospheric emission. This high emission results from a large enhancement of both ethane and acetylene in the polar region, reinforcing the evidence of enhanced ion‐related chemistry in Jupiter's auroral regions.
An Examination of Geomagnetic Induction in Submarine Cables
Authors: Boteler David H. , Chakraborty Shibaji , Shi Xueling , Hartinger Michael D. , Wang Xuan 
Published: February 2024

AbstractSubmarine cables have experienced problems during extreme geomagnetic disturbances because of geomagnetically induced voltages adding or subtracting from the power feed to the repeaters. This is still a concern for modern fiber‐optic cables because they contain a copper conductor to carry power to the repeaters. This paper provides a new examination of geomagnetic induction in submarine cables and makes calculations of the voltages experienced by the TAT‐8 trans‐Atlantic submarine cable during the March 1989 magnetic storm. It is shown that the cable itself experiences an induced electromotive force (emf) and that induction in the ocean also leads to changes of potential of the land at each end of the cable. The process for calculating the electric fields induced in the sea and in the cable from knowledge of the seawater depth and conductivity and subsea conductivity is explained. The cable route is divided into 9 sections and the seafloor electric field is calculated for each section. These are combined to give the total induced emf in the cable. In addition, induction in the seawater and leakage of induced currents through the underlying resistive layers are modeled using a transmission line model of the ocean and underlying layers to determine the change in Earth potentials at the cable ends. The induced emf in the cable and the end potentials are then combined to give the total voltage change experienced by the cable power feed equipment. This gives results very close to those recorded on the TAT‐8 cable in March 1989.
The 2022 Starlink Geomagnetic Storms: Global Thermospheric Response to a High‐Latitude Ionospheric Driver
Authors: Billett D. D. , Sartipzadeh K. , Ivarsen M. F. , Iorfida E. , Doornbos E. , Kalafatoglu Eyiguler E. C. , Pandey K. , McWilliams K. A. 
Published: February 2024

AbstractIn this study, we present ionospheric observations of field‐aligned currents from AMPERE and the ESA Swarm A satellite, in conjunction with high‐resolution thermospheric density measurements from accelerometers on board Swarm C and GRACE‐FO, for the third and 4 February 2022 geomagnetic storms that led to the loss of 38 Starlink internet satellites. We study the global storm time response of the thermospheric density enhancements, including their decay and latitudinal distribution. We find that the thermospheric density enhances globally in response to high‐latitude energy input from the magnetosphere‐solar wind system and takes at least a full day to recover to pre‐storm density levels. We also find that the greatest density perturbations occur at polar latitudes consistent with the magnetosphere‐ionosphere dayside cusp, and that there appeared to be a saturation of the thermospheric density during the geomagnetic storm on the fourth. Our results highlight the critical importance of high‐latitude ionospheric observations when diagnosing potentially hazardous conditions for low‐Earth‐orbit satellites.
Comparative Assessment of Two Global Sensitivity Approaches Considering Model and Parameter Uncertainty
Authors: Dai Heng , Liu Yujiao , Guadagnini Alberto , Yuan Songhu , Yang Jing , Ye Ming 
Published: February 2024

AbstractGlobal Sensitivity Analysis (GSA) is key to assisting appraisal of the behavior of hydrological systems through model diagnosis considering multiple sources of uncertainty. Uncertainty sources typically comprise incomplete knowledge in (a) conceptual and mathematical formulation of models and (b) parameters embedded in the models. In this context, there is the need for detailed investigations aimed at a robust quantification of the importance of model and parameter uncertainties in a rigorous multi‐model context. This study aims at evaluating and comparing two modern multi‐model GSA methodologies. These are the first GSA approaches embedding both model and parameter uncertainty sources and encompass the variance‐based framework based on Sobol indices (as derived by Dai & Ye, 2015, https://doi.org/10.1016/j.jhydrol.2015.06.034) and the moment‐based approach upon which the formulation of the multi‐model AMA indices (as derived by Dell'Oca et al., 2020, https://doi.org/10.1029/2019wr025754) is based. We provide an assessment of various aspects of sensitivity upon considering a joint analysis of these two approaches in a multi‐model context. Our work relies on well‐established scenarios that comprise (a) a synthetic setting related to reactive transport across a groundwater system and (b) an experimentally‐based study considering heavy metal sorption onto a soil. Our study documents that the joint use of these GSA approaches can provide different while complementary information to assess mutual consistency of approaches and to enrich the information content provided by GSA under model and parameter uncertainty. While being related to groundwater settings, our results can be considered as reference for future GSA studies coping with model and parameter uncertainty.
The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β
Authors: Miao Jiaxing , Li Lian , Shaheen Nargis , Wei Jianxin , Jacko Anastasia M. , Sundd Prithu , Taleb Sarah J. , Mallampalli Rama K. , Zhao Yutong , Zhao Jing 
Published: February 2024

AbstractEndothelial cell (EC) barrier disruption and inflammation are the pathological hallmarks of vascular disorders and acute infectious diseases and related conditions, including the coronavirus disease 2019 (COVID-19) and sepsis. Ubiquitination plays a critical role in regulating the stability, intracellular trafficking, and enzymatic activity of proteins and is reversed by deubiquitinating enzymes (DUBs). The role of DUBs in endothelial biology is largely unknown. In this study, we report that USP40, a poorly characterized DUB, prevents EC barrier disruption through reductions in the activation of RhoA and phosphorylation of myosin light chain (MLC) and cofilin. Furthermore, USP40 reduces EC inflammation through the attenuation of NF-ĸB activation, ICAM1 expression, and leukocyte-EC adhesion. We further show that USP40 activity and expression are reduced in response to endotoxin challenge. Global depletion of USP40 and EC-targeted USP40 depletion in mice exacerbated experimental lung injury, whereas lentiviral gene transfer of USP40 protected against endotoxin-induced lung injury. Using an unbiased approach, we discovered that the protective effect of USP40 occurs through the targeting of heat shock protein 90β (HSP90β) for its deubiquitination and inactivation. Together, these data reveal a critical protective role of USP40 in vascular injury, identifying a unique mechanistic pathway that profoundly impacts endothelial function via DUBs.
GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review
Authors: Rodriguez-Otero Paula , van de Donk Niels W. C. J. , Pillarisetti Kodandaram , Cornax Ingrid , Vishwamitra Deeksha , Gray Kathleen , Hilder Brandi , Tolbert Jaszianne , Renaud Thomas , Masterson Tara , Heuck Christoph , Kane Colleen , Verona Raluca , Moreau Philippe , Bahlis Nizar , Chari Ajai 
Published: February 2024

AbstractMultiple myeloma is a genetically complex and heterogenous malignancy with a 5-year survival rate of approximately 60%. Despite advances in therapy, patients experience cycles of remission and relapse, with each successive line of therapy associated with poorer outcomes; therefore, therapies with different mechanisms of action against new myeloma antigens are needed. G protein–coupled receptor class C group 5 member D (GPRC5D) has emerged as a novel therapeutic target for the treatment of multiple myeloma. We review the biology and target validation of GPRC5D, and clinical data from early phase trials of GPRC5D-targeting bispecific antibodies, talquetamab and forimtamig, and chimeric antigen receptor T cell (CAR-T) therapies, MCARH109, OriCAR-017, and BMS-986393. In addition to adverse events (AEs) associated with T-cell–redirection therapies irrespective of target, a consistent pattern of dermatologic and oral AEs has been reported across several trials of GPRC5D-targeting bispecific antibodies, as well as rare cerebellar events with CAR-T therapy. Additional studies are needed to understand the underlying mechanisms involved in the development of skin- and oral-related toxicities. We review the strategies that have been used to manage these GPRC5D-related toxicities. Preliminary efficacy data showed overall response rates for GPRC5D-targeting T-cell–redirecting therapies were ≥64%; most responders achieved a very good partial response or better. Pharmacokinetics/pharmacodynamics showed that these therapies led to cytokine release and T-cell activation. In conclusion, results from early phase trials of GPRC5D-targeting T-cell–redirecting agents have shown promising efficacy and manageable safety profiles, including lower infection rates compared with B-cell maturation antigen- and Fc receptor-like protein 5-targeting bispecific antibodies. Further clinical trials, including those investigating GPRC5D-targeting T-cell–redirecting agents in combination with other anti-myeloma therapies and with different treatment modalities, may help to elucidate the future optimal treatment regimen and sequence for patients with multiple myeloma and improve survival outcomes.
Single Cell Map of Human Azoospermia Testis Caused by Cyclophosphamide Chemotherapy
Authors: Cao Jian , Zhao Xueheng , Qin Zailong , Lv Shanshan , Du Lin , Liu Zhizhong , Fan Liqing , Bo Hao 
Published: February 2024

AbstractChemotherapeutic drugs will affect the process of spermatogenesis. However, most current studies on the effects of chemotherapeutic drugs on spermatogenesis are based on mouse models, with a shortage of human body evidence. In addition, the mechanism of chemotherapeutic drugs causing spermatogenesis disorder is not clear. Therefore, we have collected the testicular tissues of an inguinal-lipoma patient whose testes were resected after chemotherapy and a patient who had normal spermatogenesis disorder and underwent single-nucleus RNA sequencing (snRNA-Seq). After quality control, we obtained a total of 27,957 high-quality cells, including 18,612 normal cells and 9,345 drug-treated cells, which were all used in analyzing the mechanism of chemotherapeutic drugs causing spermatogenesis disorder. This study has provided data resources and references for exploring the mechanism of chemotherapeutic drugs causing spermatogenesis disorder with the insight of protecting the spermatogenic abilities of male tumor patients receiving chemotherapy.
Chromosome-level genome assembly and annotation of eel goby (Odontamblyopus rebecca)
Authors: Lü Zhenming , Yu Ziwei , Luo Wenkai , Liu Tianwei , Wang Yuzheng , Liu Yantang , Liu Jing , Liu Bingjian , Gong Li , Liu Liqin , Li Yongxin 
Published: February 2024

AbstractThe eel gobies fascinate researchers with many important features, including its unique body structure, benthic lifestyle, and degenerated eyes. However, genome assembly and exploration of the unique genomic composition of the eel gobies are still in their infancy. This has severely limited research progress on gobies. In this study, multi-platform sequencing data were generated and used to assemble and annotate the genome of O. rebecca at the chromosome-level. The assembled genome size of O. rebecca is 918.57 Mbp, which is similar to the estimated genome size (903.03 Mbp) using 17-mer. The scaffold N50 is 41.67 Mbp, and 23 chromosomes were assembled using Hi-C technology with a mounting rate of 99.96%. Genome annotation indicates that 53.29% of the genome is repetitive sequences, and 22,999 protein-coding genes are predicted, of which 21,855 have functional annotations. The chromosome-level genome of O. rebecca will not only provide important genomic resources for comparative genomic studies of gobies, but also expand our knowledge of the genetic origin of their unique features fascinating researchers for decades.
A single cell RNAseq benchmark experiment embedding “controlled” cancer heterogeneity
Authors: Arigoni Maddalena , Ratto Maria Luisa , Riccardo Federica , Balmas Elisa , Calogero Lorenzo , Cordero Francesca , Beccuti Marco , Calogero Raffaele A. , Alessandri Luca 
Published: February 2024

AbstractSingle-cell RNA sequencing (scRNA-seq) has emerged as a vital tool in tumour research, enabling the exploration of molecular complexities at the individual cell level. It offers new technical possibilities for advancing tumour research with the potential to yield significant breakthroughs. However, deciphering meaningful insights from scRNA-seq data poses challenges, particularly in cell annotation and tumour subpopulation identification. Efficient algorithms are therefore needed to unravel the intricate biological processes of cancer. To address these challenges, benchmarking datasets are essential to validate bioinformatics methodologies for analysing single-cell omics in oncology. Here, we present a 10XGenomics scRNA-seq experiment, providing a controlled heterogeneous environment using lung cancer cell lines characterised by the expression of seven different driver genes (EGFR, ALK, MET, ERBB2, KRAS, BRAF, ROS1), leading to partially overlapping functional pathways. Our dataset provides a comprehensive framework for the development and validation of methodologies for analysing cancer heterogeneity by means of scRNA-seq.
The comparison of species diversity and abundance of insect natural enemies in the domesticated species of cotton using the yellow pan trap method
Authors: Tenguri Prabhulinga , Kranthi Sandhya , Naik Chinna Babu , Mari Amutha , Kumar Rishi , Suke Ruchika , Nagrare Vishlesh Shankar , Narkhedkar Nandini Gokte , Waghmare Vijay Namdeo , Prasad Yenumula Gerard 
Published: February 2024

AbstractIndia is the world’s largest cotton producer and the only country that grows all four cultivated cotton species. There have been very few studies on the diversity and abundance of natural enemies of cotton insect pests in these cultivated cotton species. Therefore, the current study (2016–2018) was conducted to assess the diversity and abundance of natural enemies that cultivated cotton species harbour. Phule Dhanwantari, Suraj, Suvin, RCH-2, and DCH-32 were the five genotypes used in the study, each with a distinct genetic background. Using the adiv 2.0.1 and vegan R packages, we identified significant differences in natural enemies in terms of species diversity, richness, evenness, and abundance. Analysis of Similarity (ANOSIM) and Non-metric Multidimensional Scaling (NMDS) indicated substantial differences in the natural enemy community structure among the examined genotypes. A total of 17,279 natural enemies were collected and identified across genotypes from seven predatory families and five parasitoid families. The percentage share of these natural enemy families across genotypes and years, in descending order, is Coccinellidae (28.23%) < Tachinidae (19.23%) < Braconidae (12.68%) < Chrysopidae (11.65%) < Chalcididae (9.41%) < Aphelinidae (6.33%) < Pentatomidae (3.29%) < Ichneumonidae (2.37%) < Syrphidae (2.33%) < Vespidae (1.81%) < Asilidae (1.79%) < Geocoridae (0.89%). Coccinellidae, Tachinidae, Braconidae, Chrysopidae, Chalcididae, and Aphelinidae are the six major families that account for more than 85% of all recorded natural enemies. These six families have a higher percentage share in Phule Dhanwantary (90%) compared to the other genotypes. The conservation and better utilization of these natural enemies are crucial for the ecological and safe management of insect pests in the cotton ecosystem.
Extending deterministic transport capabilities for very-high and ultra-high energy electron beams
Authors: Naceur Ahmed , Bienvenue Charles , Romano Paul , Chilian Cornelia , Carrier Jean-François 
Published: February 2024

AbstractFocused Very-High Energy Electron (VHEE, 50–300 MeV) and Ultra-High Energy Electron (UHEE, > 300 MeV) beams can accurately target both large and deeply seated human tumors with high sparing properties, while avoiding the spatial requirements and cost of proton and heavy ion facilities. Advanced testing phases are underway at the CLEAR facilities at CERN (Switzerland), NLCTA at Stanford (USA), and SPARC at INFN (Italy), aiming to accelerate the transition to clinical application. Currently, Monte Carlo (MC) transport is the sole paradigm supporting preclinical trials and imminent clinical deployment. In this paper, we propose an alternative: the first extension of the nuclear-reactor deterministic chainNjoy-Dragonfor VHEE and UHEE applications. We have extended the Boltzmann-Fokker-Planck (BFP) multigroup formalism and validated it using standard radio-oncology benchmarks, complex assemblies with a wide range of atomic numbers, and comprehensive irradiation of the entire periodic table. We report that$$99\%$$99%of water voxels exhibit a BFP-MC deviation below$$2\%$$2%for electron energies under$$\text{1.5 GeV}$$1.5 GeV. Additionally, we demonstrate that at least$$97\%$$97%of voxels of bone, lung, adipose tissue, muscle, soft tissue, tumor, steel, and aluminum meet the same criterion between$$\text{50 MeV}$$50 MeVand$$\text{1.5 GeV}$$1.5 GeV. For water, the thorax, and the breast intra-operative benchmark, typical average BFP-MC deviations of$$0.3\%$$0.3%and$$0.4\%$$0.4%were observed at$$\text{300 MeV}$$300 MeVand$$\text{1 GeV}$$1 GeV, respectively. By irradiating the entire periodic table, we observed similar performance between lithium ($$Z=3$$Z=3) and cerium ($$Z=58$$Z=58). Deficiencies observed between praseodymium ($$Z=59$$Z=59) and einsteinium ($$Z=99$$Z=99) have been reported, analyzed, and quantified, offering critical insights for the ongoing development of the Evaluated Nuclear Data File mode inNjoy.