bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a closure device on complication rates in high‐local‐risk patients: Results of a randomized multicenter trial
Authors: Chevalier Bernard , Lancelin Bernard , Koning Rene , Henry Michel , Gommeaux Antoine , Pilliere Remy , Elbaz Meyer , Lefevre Thierry , Boughalem Kamel , Marco Jean , Dupouy Patrick 
Published: February 2003

AbstractClinical trials have shown that coronary stenting is associated with a high level of complications at the access site. Arterial sealing devices have proven their efficacy in obtaining immediate hemostasis after sheath removal, in allowing early ambulation, and in improving patient comfort. However, there is no report showing a reduction of local complications related to their use. The purpose of this multicenter study was to compare randomly the efficacy of Angio‐Seal versus compression methods of hemostasis in reducing the rate of access site complications after coronary angioplasty in 612 selected patients with higher risk of local events satisfying at least one of the following high‐risk criteria: age > 70, previous puncture at the same site, history of hypertension, treatment with ticlopidine at least 2 days before the procedure, use of abciximab, 8 Fr access, prolonged heparin treatment after the angioplasty, and use of lytics if fibrinogen > 1 g/l. Group A (n = 306) had immediate sheath removal, Angio‐Seal implantation, and cessation of bed rest 4 hr after the intervention. Group B (n = 306) had sheath removal according to local practice and cessation of bed rest 6–18 hr after the hemostasis procedure, also according to local practice. Clinical follow‐up was done at 1 hr, 4 hr, 24 hr, discharge, and 7 days and a systematic color flow duplex sonography was performed to confirm diagnosis of access site complication. In group A, device deployment and immediate hemostasis were obtained in, respectively, 96.8% and 87% of patients. Time to hemostasis was shorter in group A: 5 vs. 52 min (P < 0.001). Cessation of bed rest was dramatically reduced in group A (438 ± 450 min) vs. group B (952 ± 308 min; P < 0.001). The cumulative rate of complications, using a composite primary endpoint, at 7 days was significantly different between the two groups: 5.9% of group A patients and 18% of group B patients (P < 0.001). This difference was mainly due to the dramatic reduction of prolonged bleeding in group A patients. Angio‐Seal device use in high‐local‐risk patients allows immediate sheath removal and hemostasis with a reduction of local event rate despite a higher level of anticoagulation, compared to regular compression techniques, directly related to a dramatic decrease of prolonged bleeding. Cathet Cardiovasc Intervent 2003;58:285–291. © 2003 Wiley‐Liss, Inc.
Percutaneous suture‐mediated closure of femoral access sites deployed through the procedure sheath: Initial clinical experience with a novel vascular closure device
Authors: Eggebrecht Holger , Naber Christoph , Woertgen Uta , Ringe Sonia , Konorza Thomas F.M. , Schmermund Axel , von Birgelen Clemens , Haude Michael , Kroeger Knut , Erbel Raimund , Baumgart Dietrich 
Published: February 2003

AbstractThe objective of this study was to assess the initial safety and feasibility of a novel suture‐mediated device for closure of femoral access sites immediately after diagnostic or interventional cardiac catheterization. In a prospective study, 150 patients (mean age, 61.5 years; 109 male) underwent femoral access closure with a novel suture closure device (Superstitch, Sutura) immediately after diagnostic (n = 106) or interventional (n = 44) catheterization procedures, independently of the coagulation status. All patients were monitored for 24 hr after the procedure. The closure device was successfully deployed in 92% of patients. Immediate hemostasis was achieved in 77% of patients with no differences between patients undergoing diagnostic catheterization or coronary interventions (79% vs. 73%; P = 0.659). After 2 min of additional light manual compression, hemostasis was achieved in 92% of patients. There was one major complication requiring vascular surgery (0.7%). The novel suture closure device is a safe and effective device that allows for immediate closure of femoral puncture sites after both diagnostic and interventional procedures with a low rate of major complications. Cathet Cardiovasc Intervent 2003;58:313‐321. © 2003 Wiley‐Liss, Inc.
A review of p53 expression and mutation in human benign, low malignant potential, and invasive epithelial ovarian tumors
Authors: Kmet Leanne M. , Cook Linda S. , Magliocco Anthony M. 
Published: February 2003

AbstractBACKGROUNDIn the current study, the authors present pooled data from studies that investigated p53 protein expression and/or mutation in human epithelial ovarian tumors.METHODSThe English literature in the MEDLINE, PubMed, and Ingenta databases was searched to the end of the year 2000 to identify relevant studies. Data were pooled across eligible studies, and the prevalence of p53 expression and mutation among benign, low malignant potential (LMP), and invasive tumors was determined. Prevalence estimates by tumor histology, International Federation of Gynecology and Obstetrics (FIGO) stage, and grade also were calculated.RESULTSThe pooled prevalence estimate for p53 overexpression among epithelial ovarian carcinomas was 51% (95% confidence intervals [95% CI], 50–53%) compared with 17% (95% CI, 15–20%) among LMP tumors and 7% (95% CI, 5–10%) among benign tumors. p53 mutation prevalence estimates were 45% (95% CI, 42–47%), 5% (95% CI, 2–9%), and 1% (95% CI, 0–5%), respectively, for invasive, LMP, and benign tumors. The prevalence of these p53 abnormalities was found to be associated positively with increasing tumor grade and stage. Differences based on histologic subtype also were found.CONCLUSIONSAlthough these pooled estimates might appear to offer support for various hypotheses regarding the role of p53 in ovarian carcinoma, the limitations inherent in these data hamper the interpretation of the significance of any of the findings. Future studies will require innovative methods to address the limitations of many previous investigations and more comprehensive investigation into defective tumor suppression mechanisms. Cancer 2003;97:389–404. © 2003 American Cancer Society.DOI 10.1002/cncr.11064
EMAS and its local diffusion in Italy
Authors: Jirillo Rita , Rocchi Andrea , Martucci Olimpia 
Published: February 2003

AbstractDue to the growing awareness among enterprises of the relevance of ‘sustainable development’, applications of the Environmental Management and Audit Scheme (EMAS) in Italy are expanding. With the second era of EMAS (EMAS II), this scheme will become a global instrument, enabling Italian small and medium enterprises (SMEs) to master environmental challenges while improving their competitive position. This report intends to demonstrate that area and local agreements between local government units and research centres, such as universities or energy and environmental boards, can simplify and improve the diffusion of EMAS in the country. Reported examples of some small Italian municipalities that have applied EMAS are demonstrations of how government units can increase all citizens' quality of life while taking care of environmental aspects. Since 1993, the year of the first applications of Regulation 1836/93, local government units have understood the important role they can play in this subject.This work illustrates that the development of ISO and EMAS local applications must be based on government's local promotion aimed at encouraging enterprises to voluntarily adopt these instruments for environmental safeguard. Copyright © 2003 John Wiley & Sons, Ltd. and ERP Environment.
The changing world demography of type 2 diabetes
Authors: Green Anders , Christian Hirsch Niels , Krøger Pramming Stig 
Published: February 2003

AbstractIn recent years it has been estimated that the current global prevalence of type 2 diabetes amounts to about 150 million patients. Projections suggest that by the year 2025 the number of prevalent patients in the world will reach approximately 300 million. It is assumed that the increase in the number of patients will be most pronounced in nations currently undergoing socio‐economic development including increasing urbanization. The technique used to provide these estimates is based on results from available, contemporary survey results, combined with expected future trends in demographic indicators. We suggest that the currently available methods for the estimation of the future global burden of type 2 diabetes mellitus yield underestimates. Further modifications and validity tests of the modelling techniques are necessary in order to develop a reliable instrument to globally monitor the effects of the struggle against the diabetes problem. Copyright © 2002 John Wiley & Sons, Ltd.
A study of the buying price of photovoltaic electricity under a carbon tax regime
Authors: Kemmoku Yoshishige , Shundoh Goh , Takikawa Hirofumi , Kawamoto Teru , Sakakibara Tateki 
Published: February 2003

AbstractAssuming that photovoltaic (PV) systems are adopted in residential houses under a carbon tax regime, the economic performance of PV systems is investigated from the standpoint of an electric utility. The economic performance is estimated by using the buying price of PV electricity and the PV economic index, which is defined as the ratio of the buying price to the generation cost of the electric utility. Because these values depend on electric power development and operation, the best mix and the operation of power plants are obtained by linear programming subject to restrictions on power generation. Then, the buying price of PV electricity is calculated from the total cost of the electric utility. The buying price means the upper limit at which the electric utility never suffers a loss. The buying price is also compared with the power generation cost. The parameters are the prevalence attainment ratio of PV systems (0 to 100%), the upper limit of newly developed nuclear power plants (0 to 4 GW/10 y), and the generated energy ratio of coal‐fired thermal plants (0 to 15%). Chubu Electric Power Company, Inc. is used as the electric utility. The calculation results show that the buying price of PV electricity increases linearly with increasing carbon tax rate, and its values are 9 and 11.5 yen/kWh when the carbon tax rate is 0 and 25 thousand yen/t‐C, respectively, which does not depend on the prevalence attainment ratio of PV systems and the upper limit of newly developed nuclear power plants. It is not the carbon tax rate but the newly developed nuclear power plant that influences the PV economic index. The values of the PV economic index are 1.35 to 1.45 and 1.50 to 1.60 when the newly developed nuclear power plant capacity is 0 and 4 GW/10 y, respectively. These results show that the economic performance of PV systems is increased by developing nuclear power plants at a certain rate and introducing a carbon tax. © 2003 Wiley Periodicals, Inc. Electr Eng Jpn, 143(2): 38–49, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.10067
A study of a micro co‐generation system's conformation for residential use considering observed fluctuating characteristics of hot‐water demand
Authors: Kato Takeyoshi , Iida Tetsuhisa , Wu Kai , Suzuoki Yasuo 
Published: February 2003

AbstractThis paper discusses a conformation of a micro co‐generation system (µCGS) for residential use. The evaluation is based on the hot‐water demand observed in three families who live in the same apartment house. Assuming DSS operation of µCGS, we evaluated the required capacity of PEFC, hot‐water tank, and backup boiler to meet a series of daily hot‐water demand observed in three houses. The results are: (1) µCGS with 2‐kW PEFC and 350‐L hot‐water tank are required in family B when µCGS is not equipped with the backup boiler, (2) the additional 5 kW of the backup boiler reduces the required capacity of the hot‐water tank by 50 L, (3) the evaluation based on hourly averaged hot‐water demand patterns would underestimate the required capacity of the hot‐water tank, (4) the required capacity of the hot‐water tank could be reduced by the leveling effect of the hot‐water demand pattern along three families. © 2003 Wiley Periodicals, Inc. Electr Eng Jpn, 143(2): 30–37, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.10080
Calculation method for strand current distributions in armature winding of a turbine generator
Authors: Takahashi Kazuhiko , Takahashi Miyoshi , Sato Masaki 
Published: February 2003

AbstractWe have developed a calculation method for the strand current distributions in the turbine generator armature windings. These distributions are calculated by using a circuit equation and a 3D finite element method. In the circuit equation, the strand current is solved by introducing a circulating current at each strand of the armature windings. The induced voltage in the circuit equation is produced by leakage flux of the coil end region. The leakage flux is obtained by the 3D finite element method. The calculated strand current distributions had good agreement with the measurements of 360°, 450°, and 540° transposed model coils. © 2003 Wiley Periodicals, Inc. Electr Eng Jpn, 143(2): 50–58, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.10131
Analytical platforms to assess the authenticity of cocoa butter
Authors: Ulberth Franz , Buchgraber Manuela 
Published: February 2003

AbstractThis paper reviews strategies to detect and analyse cocoa butter equivalents added to genuine cocoa butter or to chocolate products. The legal background of the issue is that current European legislation allows the addition of vegetable fats other than cocoa butter to chocolate up to a level of 5% of the product weight, provided that the addition is correctly indicated on the label. However, the Directive fails to specify a method of analysis to enforce compliance.The principal themes highlight compositional data (triglyceride and fatty acid composition, components of the unsaponifiable matter) of cocoa butter from different origins and suitable raw materials used for the formulation of cocoa butter equivalents, and explains how analytical techniques (gas‐liquid chromatography, high‐performance liquid chromatography, infrared spectroscopy, pyrolysis mass spectrometry) make use of subtle differences between the two commodities to detect commingling.
AMPA/kainate receptors in mouse spinal cord cell‐specific display of receptor subunits by oligodendrocytes and astrocytes and at the nodes of Ranvier
Authors: Brand‐Schieber Elimor , Werner Peter 
Published: February 2003

AbstractSpinal cord white matter is susceptible to AMPA/kainate (KA)‐type glutamate receptor‐mediated excitotoxicity. To understand this vulnerability, it is important to characterize the distribution of AMPA/KA receptor subunits in this tissue. Using immunohistochemistry and laser confocal microscopy, we studied the expression sites of AMPA/KA receptor subunits in mouse spinal cord. The white matter showed consistent immunoreactivity for AMPA receptor subunit GluR2/3 and KA receptor subunits GluR6/7 and KA2. In contrast, antibodies against GluR1, GluR2, GluR4 (AMPA), and GluR5 (KA) subunits showed only weak and occasional labeling of white matter. However, gray matter neurons did express GluR1 and GluR2, as well as GluR2/3. The white matter astrocytes were GluR2/3 and GluR6/7 immunopositive, while the gray matter astrocytes displayed primarily GluR6/7. Both exclusively and abundantly, KA2 labeled oligodendrocytes and myelin, identified by CNPase expression. Interestingly, myelin basic protein, another myelin marker, showed less correlation with KA2 expression, placing KA2 at specific CNPase‐containing subdomains. Focal points of dense KA2 labeling showed colocalization with limited, but distinct, axonal regions. These regions were identified as nodes of Ranvier by coexpressing the nodal marker, ankyrin G. Overall, axonal tracts showed little, if any, AMPA/KA receptor expression. The proximity of oligodendrocytic KA2 to the axonal node and the paucity of axonal AMPA/kainate receptor expression suggest that excitotoxic axonal damage may be secondary and, possibly, mediated by oligodendrocytes. Our data demonstrate differential expression of glutamate AMPA and KA receptor subunits in mouse spinal cord white matter and point to astrocytes and oligodendrocytes as potential targets for pharmacological intervention in white matter glutamate excitotoxicity. GLIA 42:12–24, 2003. © 2003 Wiley‐Liss, Inc.
Functional characterization of mannose receptor expressed by immunocompetent mouse microglia
Authors: Zimmer Heiko , Riese Sigrid , Régnier‐Vigouroux Anne 
Published: February 2003

AbstractThe mannose receptor is a pattern‐recognition receptor involved in innate and adaptive immunity. The receptor is mainly expressed by macrophages and, within the brain, by astrocytes and microglia. This study reports for the first time the effects of two classical proinflammatory (interferon‐γ, IFNγ) and anti‐inflammatory (interleukin‐4, IL‐4) cytokines on the levels of expression and activity of the mannose receptor expressed by mouse microglia, the brain resident macrophages. As observed for macrophages, IFNγ treatment led to a decrease and IL‐4 to an increase of mannose receptor expression. Consequently, the rates of pinocytosis were strongly upregulated by IL‐4 and inhibited by IFNγ. This latter, however, resumed with time and reached again the constitutive rate of pinocytosis. This recovery resulted from an increased pinocytic activity of the few mannose receptor molecules still expressed by IFNγ‐treated microglia. This may suggest a brain‐specific regulation of the effects of IFNγ since such a phenomenon has not been observed in macrophages. Together, these observations demonstrate that cytokine‐stimulated immunocompetent microglia express a functional mannose receptor. GLIA 41:89–100, 2003. © 2003 Wiley‐Liss, Inc.
Protective effect of glial cells against lipopolysaccharide‐mediated blood‐brain barrier injury
Authors: Descamps Laurence , Coisne Caroline , Dehouck Bénédicte , Cecchelli Romeo , Torpier Gérard 
Published: February 2003

AbstractNumerous infections of the central nervous system are characterized by altered blood‐brain barrier (BBB) functions leading to brain damage. To study the mechanisms that cause BBB disruption in these pathologies, we used an in vitro BBB model consisting of a coculture of brain capillary endothelial cells and glial cells. When these endothelial cells were submitted alone to lipopolysaccharide (LPS), added in the luminal compartment, a huge increase in the paracellular permeability of the monolayer was observed. As glial cells surrounding the brain capillaries are of prime importance in specifying at least some cellular properties, we investigated whether glial cells would be able to modulate this endothelial cell response to LPS. When endothelial cells were incubated with LPS added luminally, in the presence of glial cells, LPS surprisingly had no effect on the endothelial cell monolayer permeability, suggesting a protective effect of glial cells on the LPS‐mediated injury. As in our experiments, the endotoxin does not interact with the glial cell population. This protective effect suggests a close communication between cerebral endothelial cells and brain parenchymal cells. In our coculture model, the glial cell population is a mixture of astrocytes, oligodendrocytes, and microglial cells. Further experiments performed with purified astrocytes showed that microglial cells or oligodendrocytes, or both, are essential for the complete protection of the endothelial cell monolayer integrity. All these results are direct evidence for a modulatory effect of glial cells on brain capillary endothelial cell response in the pathogenesis of endotoxemia. GLIA 42:46–58, 2003. © 2003 Wiley‐Liss, Inc.
Perceived social support from supervisor and group members' psychological and situational characteristics as predictors of subordinate performance in Thai work units
Authors: Bhanthumnavin Duchduen 
Published: February 2003

AbstractThe main purpose of this study was to examine the relationship between three dimensions of perceived social
support from supervisor (PSSS) (emotional, informational, and material) and subordinate
performance (self‐report and supervisory rating). The second purpose was to study the effects of
psychological and situational factors on subordinate performance.Usable data of 355 matched supervisor‐subordinate pairs working in health centers in Thailand were
analyzed. Results revealed that female subordinates receiving all three types of support received higher performance
ratings from their supervisors than did their male counterparts. Perceived organizational support,
self‐efficacy, and location of workplace were also associated with subordinate performance. Discussion,
recommendations for future research, implications for HRD in Thailand, and limitations are presented.
Biological and caregiver correlates of behavioral inhibition
Authors: Partridge Ty 
Published: February 2003

AbstractThe aim of this study was to explore the relationships among measures of behavioral inhibition, physiological reactivity, and caregiver attitudes. Measures comprised of heart rate; survey assessments of caregiver empathy with the child, appropriateness of caregiver developmental expectations of the child, and use of positive discipline techniques; and observational measures of behavioral inhibition were gathered in a laboratory setting on 72, 5–6‐year old children. It was found that heart rate and behavioral inhibition were positively correlated (0.595), whereas behavioral inhibition was negatively correlated with caregiver attitudes of empathy (−0.356), appropriate expectations (−0.366), and use of positive discipline techniques (−0.275). However, there was no correlation between heart rate and caregiver attitudes. These data suggest that physiological reactivity to novel stimuli and caregiver attitudes of empathy, appropriate expectations, and use of positive discipline techniques conjointly influence behavioral inhibition in early childhood. Further, these three caregiver variables accounted for significant variance in children who had high reactive physiological profiles associated with inhibited behavior patterns, but did not display such patterns. Copyright © 2003 John Wiley & Sons, Ltd.
A longitudinal examination of the transition to symbolic communication in the second year of life
Authors: Camaioni Luigia , Aureli Tiziana , Bellagamba Francesca , Fogel Alan 
Published: February 2003

AbstractBetween 10 and 24 months of age, children progress from communicating through conventional signals to communicating through symbols in a variety of situations. The present study investigates this transition analysing mother–child communication frames and the child's communicative acts, and tracing the developmental changes in both frames and communicative acts. Four children (2 girls, 2 boys) and their mothers were observed longitudinally and extensively, from 10 to 24 months of age, using a multiple case‐study method. Through the detailed investigation of these single cases, clear developmental rajectories were found, showing that conventional frames and representational gestures ‘bridge’ the transition from attentional to symbolic communication. There were significant differences between dyads and children in the developmental trajectories for several frames and communicative acts. The results not only confirm previous findings on the development of verbal and gestural communication, but provide new insights into the transition to symbolic communication in the second year of life, first because of the use of frame analysis and second because of a focus on individual trajectories in development. Copyright © 2003 John Wiley & Sons, Ltd.