bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crystallographic report: Tetraphenylphosphonium nitratobis (chlorodiphenylstannate)methane, [Ph4P]+[(Ph2ClSn)2CH2 ·NO3]−
Authors: Jurkschat Klaus , Tiekink Edward R. T. 
Published: September 2003

AbstractThe nitrate anion coordinates to the SnCH2Sn unit of the title phosphonium stannate, [Ph4P]+ [(Ph2ClSn)2CH2 ·NO3]−, to give a six‐membered ring having the penta‐coordinated tin atoms in a trigonal bipyramidal geometry. Copyright © 2003 John Wiley & Sons, Ltd.
A multicriteria ranking of organotin(IV) compounds with fungicidal properties
Authors: Ayoko Godwin A. , Bonire Josiah J. , Abdulkadir Shettima S. , Olurinola Philip F. , Ehinmidu Joseph O. , Kokot Serge , Yiasel Stephen 
Published: September 2003

AbstractThe application of multicriteria decision‐making methods to the results of in vitro antifungal properties of organotin compounds of the type PhxSnXz (x = 2 or 3; X = O2CC6H4OH, O2CC6H4OCOCH3, Cl or O2CCH3; z = 1 or 2) and of free 2‐hydroxybenzoic and 2‐acetoxybenzoic acids against Aspergillus niger, Aspergillus flavus, Candida albicans, Penicillium citrinum, Trichophyton rubrum and Trichophyton violaceum have been described. Ranking information necessary to select one toxicant in preference to others and to assess the properties influencing the preference has been obtained. Patterns in the multivariate analyses suggest that cationic and anionic moieties of the toxicant play some roles in their fungicidal activities. The triphenyltin compounds were generally more active than their diphenyltin analogues, but the acetoxybenzoates were more active than the corresponding hydroxybenzoates, acetates or chlorides. Thus, triphenyltin acetoxybenzoate is up to 7.5 times as active as the corresponding acetate, which is commercially marketed as a fungicide. The results of the analyses have been discussed in the light of the mechanism of antifungal activity of organotin compounds and the potential of multivariate data analysis techniques to facilitate the screening and ranking of antifungal agents. Copyright © 2003 John Wiley & Sons, Ltd.
Butyltins biomagnification from macroalgae to green sea urchin: a field assessment
Authors: Mamelona Jean , Pelletier Émilien 
Published: September 2003

AbstractBiomagnification of butyltins (BTs) was examined in a simple food web including seawater, macroalgae (Alaria esculenta, Laminaria longicruris, Ulvaria obscura) and green urchin (Strongylocentrotus droebachiensis). The study was conducted in shallow waters of the St Lawrence Estuary (Canada) adjacent to two areas potentially contaminated by BTs. Levels of tri‐ (TBT), di‐ (DBT) and mono‐BT (MBT) were determined in seawater, green urchin (including faecal matter after sampling) and macroalgae surrounding the urchins at each sampling site. The concentrations of TBT in seawater from all stations were relatively low (3–7 ngSn l−1), and both the TBT and the total BTs (∑BT = MBT + DBT + TBT) concentrations decreased with increase in distance from the BT sources. The concentrations of TBT in algae were 0.35 ngSn g−1 dry weight (DW) in A. esculenta, 0.40 ngSn g−1 DW in L. longicruris and 3.58 ngSn g−1 DW in U. obscura. Following their location, green urchins feeding mainly on these algae accumulated BTs at levels ranging from 4 to 85 ngSn g−1 DW in gonads and from 35 to 334 ngSn g−1 DW in gut. The mean bioconcentration factor (BCF) calculated from seawater to algae ranged from 17 in A. esculenta to 151 in U. obscura, whereas the biomagnification factor (BMF) from algae to urchins ranged from 2 to 17 in gonads and from 10 to 67 in gut. The overall bioaccumulation factor of TBT between seawater and internal organs of urchins reached an average value of 1.2 × 103. These results are the first to illustrate high BT BCFs and BMFs in human‐edible macroalgae and urchins sampled from northern coastal areas with a low TBT contamination level. Copyright © 2003 John Wiley & Sons, Ltd.
Crystallographic report: The two‐dimensional crystal structure of bis(trimethyltin)succinate, [(Me3Sn)2(O2CCH2CH2CO2)]∞
Authors: Cisse Ibrahima , Gueye Omar , Mahieu Bernard , Tinant Bernard , Tiekink Edward R. T. 
Published: September 2003

AbstractA two‐dimensional layer structure is found in the title compound comprising interconnected 22‐membered rings and trans‐C3O2 trigonal bipyramidal coordination geometries for tin. Copyright © 2003 John Wiley & Sons, Ltd.
Silica‐supported 3‐4,5‐dihydroimidazol‐1‐yl‐propyltriethoxysilanedichloropalladium(II) complex: Heck and Suzuki cross‐coupling reactions
Authors: Gurbuz Nevin , Özdemir İsmail , Çetinkaya Bekir , Seçkin Turgay 
Published: September 2003

AbstractA novel mesoporous silica‐nanotube‐supported 3‐4,5‐dihydroimidazol‐1‐yl‐propyltriethoxysilanedichloropalladium(II) complex was prepared and characterized. 3‐4,5‐Dihydroimidazol‐1‐yl‐propyltriethoxysilanedichloropalladium(II) and mesoporous silica‐supported 3‐4,5‐dihydroimidazol‐1‐yl‐propyltriethoxysilanedichloropalladium(II) were tested for catalytic activity for Heck coupling reactions between styrene and several aryl halides and Suzuki coupling reactions between phenylboronic acid and several aryl halides. Copyright © 2003 John Wiley & Sons, Ltd.
M. Nath, S. Phokaria, X. Song, G. Eng, M. Gielen, M. Kemmer, M. Biesemans, R. Willem and D. de Vos, ‘New organotin(IV) derivatives of dipeptides as models for metal–protein interactions: in vitro anti‐tumour activity’ Applied Organometallic Chemistry 2003; 17(5): 305–314
Authors: Nath Mala , Pokharia Sandeep , Song Xueqing , Eng George , Gielen Marcel , Kemmer Martine , Biesemans Monique , Willem Rudolph , de Vos Dick 
Published: September 2003

AbstractThe original article to which these Errata refer was published in the journal Applied Organometallic Chemistry 2003; 17(5): 305–314. Copyright © 2003 John Wiley & Sons, Ltd.
Genomics spawns novel approaches to mosquito control
Authors: Justice Robin W. , Biessmann Harald , Walter Marika F. , Dimitratos Spiros D. , Woods Daniel F. 
Published: September 2003

AbstractIn spite of advances in medicine and public health, malaria and other mosquito‐borne diseases are on the rise worldwide. Although vaccines, genetically modified mosquitoes and safer insecticides are under development, herein we examine a promising new approach to malaria control through better repellents. Current repellents, usually based on DEET, inhibit host finding by impeding insect olfaction, but have significant drawbacks. We discuss how comparative genomics, using data from the Anopheles genome project, allows the rapid identification of members of three protein classes critical to insect olfaction: odorant‐binding proteins, G‐protein‐coupled receptors, and odorant‐degrading enzymes. A rational design approach similar to that used by the pharmaceutical industry for drug development can then be applied to the development of products that interfere with mosquito olfaction. Such products have the potential to provide more complete, safer and longer lasting protection than conventional repellents, preventing disease transmission by interrupting the parasite life cycle. BioEssays 25:1011–1020, 2003. © 2003 Wiley Periodicals, Inc.
Challenging the dogma: the hidden layer of non‐protein‐coding RNAs in complex organisms
Authors: Mattick John S. 
Published: September 2003

AbstractThe central dogma of biology holds that genetic information normally flows from DNA to RNA to protein. As a consequence it has been generally assumed that genes generally code for proteins, and that proteins fulfil not only most structural and catalytic but also most regulatory functions, in all cells, from microbes to mammals. However, the latter may not be the case in complex organisms. A number of startling observations about the extent of non‐protein‐coding RNA (ncRNA) transcription in the higher eukaryotes and the range of genetic and epigenetic phenomena that are RNA‐directed suggests that the traditional view of the structure of genetic regulatory systems in animals and plants may be incorrect. ncRNA dominates the genomic output of the higher organisms and has been shown to control chromosome architecture, mRNA turnover and the developmental timing of protein expression, and may also regulate transcription and alternative splicing. This paper re‐examines the available evidence and suggests a new framework for considering and understanding the genomic programming of biological complexity, autopoietic development and phenotypic variation. BioEssays 25:930–939, 2003. © 2003 Wiley Periodicals, Inc.
Searching for sleep mutants of Drosophila melanogaster
Authors: Cirelli Chiara 
Published: September 2003

AbstractThe functions of sleep are still unknown, but are probably related to cellular and molecular aspects of neural function. To better understand the benefits that sleep may bring at the cellular level, recent studies have employed Drosophila melanogaster as a model system and shown that fruit flies share the fundamental features of mammalian sleep. As in mammals, sleep in Drosophila is characterized by increased arousal threshold and by changes in brain electrical activity. Fly sleep is homeostatically regulated independent of the circadian clock, is modulated by stimulants and hypnotics, and is affected by age. Also, fly sleep is associated with changes in brain gene expression similar to those observed in mammals. While Drosophila neurobiology is sufficiently complex to permit meaningful generalizations to mammals and humans, Drosophila genetics is simple enough to allow a rapid mutagenesis screening. An ongoing mutagenesis study has screened ∼5000 mutant Drosophila lines and found that sleep amount, sleep pattern, and the homeostatic regulation of sleep are highly conserved phenotypes in flies. So far, this study has identified 10 short sleeper lines and 4 lines that show no sleep rebound after sleep deprivation. Ultimately, the characterization of these lines should help identifying crucial cellular pathways involved in the regulatory mechanisms of sleep and its functional consequences. BioEssays 25:940–949, 2003. © 2003 Wiley Periodicals, Inc.
A perspective for understanding the modes of juvenile hormone action as a lipid signaling system
Authors: Wheeler Diana E. , Nijhout H. F. 
Published: September 2003

AbstractThe juvenile hormones of insects regulate an unusually large diversity of processes during postembryonic development and adult reproduction. It is a long‐standing puzzle in insect developmental biology and physiology how one hormone can have such diverse effects. The search for molecular mechanisms of juvenile hormone action has been guided by classical models for hormone–receptor interaction. Yet, despite substantial effort, the search for a juvenile hormone receptor has been frustrating and has yielded limited results. We note here that a number of lipid‐soluble signaling molecules in vertebrates, invertebrates and plants show curious similarities to the properties of juvenile hormones of insects. Until now, these signaling molecules have been thought of as uniquely evolved mechanisms that perform specialized regulatory functions in the taxon where they were discovered. We show that this array of lipid signaling molecules share interesting properties and suggest that they constitute a large set of signal control and transduction mechanisms that include, but range far beyond, the classical steroid hormone signaling mechanism. Juvenile hormone is the insect representative of this widespread and diverse system of lipid signaling molecules that regulate protein activity in a variety of ways. We propose a synthetic perspective for understanding juvenile hormone action in light of other lipid signaling systems and suggest that lipid activation of proteins has evolved to modulate existing signal activation and transduction mechanisms in animals and plants. Since small lipids can be inserted into many different pathways, lipid‐activated proteins have evolved to play a great diversity of roles in physiology and development. BioEssays 25:994–1001, 2003. © 2003 Wiley Periodicals, Inc.
Paroxysms of excitement: sodium channel dysfunction in heart and brain
Authors: Head Cathy , Gardiner Mark 
Published: September 2003

AbstractInherited disorders of ion‐channels are associated with paroxysmal dysfunction of excitable tissues and manifest as diseases of the brain, heart and skeletal muscle. These so‐called channelopathies have now been described for most of the major categories of voltage‐dependent ion‐channels including those selectively permeable to sodium. Sodium channelopathies affecting the heart and brain are reviewed in this essay. They show striking differences and similarities including, for example, their responsiveness to changes in body temperature and sleep state. They represent a paradigm for efforts to trace disturbed behaviour of physiological systems back to its molecular origins and understanding their molecular basis may provide clues to important health issues such as cardiac side effects of drugs and response to medication used to treat epilepsy. BioEssays 25:981–993, 2003. © 2003 Wiley Periodicals, Inc.
Motor protein control of ion flux is an early step in embryonic left–right asymmetry
Authors: Levin Michael 
Published: September 2003

AbstractThe invariant left–right asymmetry of animal body plans raises fascinating questions in cell, developmental, evolutionary, and neuro‐biology. While intermediate mechanisms (e.g., asymmetric gene expression) have been well‐characterized, very early steps remain elusive. Recent studies suggested a candidate for the origins of asymmetry: rotary movement of extracellular morphogens by cilia during gastrulation. This model is intellectually satisfying, because it bootstraps asymmetry from the intrinsic biochemical chirality of cilia. However, conceptual and practical problems remain with this hypothesis, and the genetic data is consistent with a different mechanism. Based on wide‐ranging data on ion fluxes and motor protein action in a number of species, a model is proposed whereby laterality is generated much earlier, by asymmetric transport of ions, which results in pH/voltage gradients across the midline. These asymmetries are in turn generated by a new candidate for “step 1”: asymmetric localization of electrogenic proteins by cytoplasmic motors. BioEssays 25:1002–1010, 2003. © 2003 Wiley Periodicals, Inc.
The Cdx1 homeodomain protein: an integrator of posterior signaling in the mouse
Authors: Lohnes David 
Published: September 2003

AbstractThe vertebrate Cdx genes (Cdx1 Cdx2 and Cdx4 in the mouse) encode homeodomain transcription factors related to the Drosophila caudal gene. The vertebrate Cdx gene products have been implicated in the development of the posterior embryo. In particular, loss‐ and gain‐of‐function experiments suggest that Cdx members are direct regulators of Hox genes and likely impart posterior information, in part, through this mechanism. Several signaling molecules, notably retinoic acid (RA*) and members of the Wnt (wingless) and fibroblast growth factor (FGF) families, are also implicated in patterning of the posterior vertebrate embryo. Interestingly, recent work indicates that members of the Cdx family are targets of Wnt, RA and FGF signaling, suggesting that Cdx factors act to convey the activity of these signaling molecules to Hox genes. This article will briefly review Cdx expression and function, with particular emphasis on vertebrate model systems. BioEssays 25:971–980, 2003. © 2003 Wiley Periodicals, Inc.
Apical meristems: the plant's fountain of youth
Authors: Bäurle Isabel , Laux Thomas 
Published: September 2003

AbstractDuring postembryonic development, all organs of a plant are ultimately derived from a few pluripotent stem cells found in specialized structures called apical meristems. Here we discuss our current knowledge about the regulation of plant stem cells and their environments with main emphasis on the shoot apical meristem of Arabidopsis thaliana. Recent studies suggest that stem cells are localized in specialized niches where signals from surrounding cells maintain their undifferentiated state. In the shoot meristem, initiation of stem cells during embryogenesis, regulation of stem‐cell homeostasis and termination of stem‐cell maintenance during flower development appear to primarily involve regulation of the stem‐cell niche. BioEssays 25:961–970, 2003. © 2003 Wiley Periodicals, Inc.
Detecting functional interactions in a gene and signaling network by time‐resolved somatic complementation analysis
Authors: Marwan Wolfgang 
Published: September 2003

AbstractSomatic complementation by fusion of two mutant cells and mixing of their cytoplasms occurs when the genetic defect of one fusion partner is cured by the functional gene product provided by the other. We have found that complementation of mutational defects in the network mediating stimulus‐induced commitment and sporulation of Physarum polycephalum may reflect time‐dependent changes in the signaling state of its molecular building blocks. Network perturbation by fusion of mutant plasmodial cells in different states of activation, and the time‐resolved analysis of somatic complementation effects can be used to systematically probe network structure and dynamics. Time‐resolved somatic complementation quantitatively detects regulatory interactions between the functional modules of a network, independent of their biochemical composition or subcellular localization, and without being limited to direct physical interactions. BioEssays 25:950–960, 2003. © 2003 Wiley Periodicals, Inc.
Bacteroides thetaiotaomicron: a dynamic, niche‐adapted human symbiont
Authors: Comstock Laurie E. , Coyne Michael J. 
Published: September 2003

AbstractThe coevolution of humans with their intestinal microflora has resulted in cooperative relationships that have shaped the biology and the genomes of these symbiotic partners. Bacteroides thetaiotaomicron is one such bacterial symbiont that is a dominant member of the intestinal microbiota of humans and other mammals. The recent report of the genome sequence of B. thetaiotaomicron1 is the first reported for an abundant Gram‐negative organism of the human colonic microbiota and, as such, provides the first glimpse on a genomic scale of the genetic arsenal used by a Gram‐negative symbiont to dominate in this ecosystem. The genome has revealed large expansions of many paralogous groups of genes that encode products essential to the organism's ability to successfully compete in this environment. Most noteable is the organism's abundant machinery for utilizing a large variety of complex polysaccharides as a source of carbon and energy. The proteome also reveals the organism's extensive ability to adapt and regulate expression of its genes in response to the changing ecosystem. These factors, as well as others highlighted below, suggest an incredibly flexible and adaptable organism that is exquisitely equipped to dominate in its challenging and competitive niche. BioEssays 25:926–929, 2003. © 2003 Wiley Periodicals, Inc.
Cell diversity in the retina: more than meets the eye
Authors: Cook Tiffany 
Published: September 2003

AbstractOver 10 years ago, Pax‐6 was shown to play an evolutionarily conserved role in controlling eye formation from Drosophila to humans.1 Since then, the identification of an entire cascade of conserved eye determination genes has brought a new understanding to the developmental relationship between the insect compound eye and the vertebrate camera eye.2 Additional studies are now beginning to suggest that even late aspects of eye development, including cell type specification, also share common molecular machinery. In this commentary, I will discuss some of these findings, with a particular focus on the recent study by Dyer et al.3 describing a novel role for the Prox1 transcription factor in specifying horizontal cells in the mouse retina. As Prospero, the Drosophila homolog of Prox1, also participates in retinal cell specification, these data provide a forum for asking new questions concerning pathways that may regulate retinogenesis across evolution. BioEssays 25:921–925, 2003. © 2003 Wiley Periodicals, Inc.
Trends in sustainability reporting by the Fortune Global 250
Authors: Kolk Ans 
Published: September 2003

AbstractAgainst the background of critique on the negative social and environmental implications of globalization, multinational enterprises have become active in reporting on activities undertaken to prevent these ‘externalities’ of international trade and production. This article analyses to what extent and in what form the trend towards non‐financial reporting, which started in the 1990s, has continued in the 21st century. It presents both trend and panel data of the Fortune Global 250 in 1998 and 2001, showing a continued and significant rise of sustainability reporting to approximately half of these multinationals, with some sector and country variations. One‐third of the reports are externally verified. Especially in Europe and Japan, the ‘sustained’ nature of sustainability reporting is accompanied by regulatory requirements and government encouragements. The number of reports that includes social (and sometimes also financial) issues has increased considerably. The article also shows that in these reports the more ‘traditional’ topics, on the environment, corporate philanthropy and employees, receive much more attention than the broader external societal issues. It concludes with a reflection on the extent to which current forms of disclosure might address the concerns raised about multinationals' behaviour. Copyright © 2003 John Wiley & Sons, Ltd and ERP Environment.
A typology of stakeholder participation for company environmental decision‐making
Authors: Green Abigail Oxley , Hunton‐Clarke Lynsey 
Published: September 2003

AbstractCompanies now recognise the need to identify and address the concerns of their stakeholders to ensure their decisions and business activities are more socially acceptable. However, despite stakeholder participation being widely accepted in the public sector and used to a limited extent within some business management processes, there is no accepted understanding of what stakeholder participation actually constitutes and certainly no systematic method for its application within companies and company decision‐making. In order to support the development of such a method, stakeholder participation must first be defined in the ‘company’ context. Drawing from previous typologies of participation outlined in the literature, particularly relating to the public sector, this paper proposes a typology of stakeholder participation for companies, with particular relevance to environmental issues. It also outlines the needs and problems associated with developing a method of stakeholder participation for use in company decision‐making. Copyright © 2003 John Wiley & Sons, Ltd and ERP Environment.
Capability building through adversarial relationships: a replication and extension of Clarke and Roome (1999)
Authors: Heugens Pursey P. M. A. R. 
Published: September 2003

AbstractCooperative interorganizational relationships are seen by many as indispensable vehicles for accessing external knowledge and accumulating capabilities. Surprisingly, the question of whether companies can also build capabilities through adversarial relationships has received little attention. This paper reports a study of the learning–action network of a major Anglo‐Dutch food and personal care company. The firm's present relationships with consumer representatives and environmental activists are strongly adversarial, due to the recent introduction of genetically modified ingredients. The study shows that companies can still build capabilities in a hostile environment, but that adversity influences capability building processes as well as capability content. Copyright © 2003 John Wiley & Sons, Ltd and ERP Environment.