bluuebunny/crossref_metadata_2025_split huggingface dataset:
AM Bench 2022 Macroscale Tensile Challenge at Different Orientations (CHAL-AMB2022-04-MaTTO) and Summary of Predictions
Authors: Moser Newell , Benzing Jake , Kafka Orion L. , Weaver Jordan , Derimow Nicholas , Rentz Ross , Hrabe Nikolas 
Published: January 2024

AbstractThe additive manufacturing benchmarking challenge described in this work was aimed at the prediction of average stress–strain properties for tensile specimens that were excised from blocks of non-heat-treated IN625 manufactured by laser powder bed fusion. Two different laser scan strategies were considered: an X-only raster and an XY raster, which involved a 90$$^\circ $$

∘

rotation in the scan direction between subsequent layers. To measure anisotropy, multiple tensile orientations with respect to the build direction were investigated (e.g., parallel, perpendicular, and intervals in between). Benchmark participants were provided grain structure information via electron backscatter diffraction measurements, as well as the stress–strain response for tensile specimens manufactured parallel to the build direction and produced by the XY scan strategy. Then, participants were asked to predict tensile properties, like the ultimate tensile strength, for the remaining specimens and orientations. Interestingly, the measured mechanical properties did not vary linearly as a function of tensile orientation. Moreover, specimens manufactured with the XY scan strategy exhibited greater yield strength than those corresponding to the X-only scan strategy, regardless of orientation. The benchmark data have been made publicly available for anyone that is interested [1]. For the modeling aspect of the challenge, five teams participated in this benchmark. While most of the models incorporated a crystal plasticity framework, one team chose to use a more semiempirical approach and to great success. However, no team excelled at all the predictions, and all teams were seemingly challenged with the predictions associated with the X-only scan strategy.
Understanding the bonding mechanism in short-time resistance projection welding: a comprehensive analysis
Authors: Koal Johannes , Baumgarten Martin , Zschetzsche Jörg , Schmale Hans Christian 
Published: January 2024

AbstractCapacitor discharge welding (CDW) is characterized by a pulsed electrical current profile. It is primarily utilized for resistance projection welding tasks, offering high power densities and short welding times. According to the latest findings, the welding process can be divided into different phases: contacting, activating, material connection, and holding pressure. During the activation phase, high-speed video-imaging reveals the generation of metal vapor which effectively eliminates impurities and oxide layers from the contact zone. The result of this is an activated surface. The purpose of this paper is to describe the physical effects of the bonding mechanism during short-time resistance welding. The Chair of Joining Technology and Assembly at the Technische Universität Dresden has a laboratory facility that can interrupt the welding current at any desired time during capacitor discharge welding. This allows different welding current profiles with always the same current rise time to be scientifically investigated. The experimental findings were supplemented with simulative analyses to clarify the bonding mechanism in resistance projection welding. Three different surface conditions are considered to generalize the findings on the bonding mechanism. Temperature and current density distributions were assessed to provide a physical description of the activation phase. The power density in the joining zone at different interruption times is determined, which gives an indication of activation by metal vaporization. The material connection is determined experimentally for the same interruption times. The numerical simulation model can be used to describe the bonding mechanism in short-time resistance welding. In resistance welding, the bond is formed due to the molten phase (solidification structure). In short-time resistance welding, the bond is formed due to surface activation by metal vaporization.
The influence of various grease compositions and silver nanoparticle additives on electrically induced rolling-element bearing damage
Authors: Bond Samuel , Jackson Robert L. , Mills German 
Published: January 2024

AbstractLeakage currents accelerate surface degradation of metal contacts via small scale arcing across lubricating films, but recent observations suggest that metallic nanoparticle additives in lubricants may be useful to improve contact performance. These findings prompted a study that examined electrically induced surface pitting of steel contacts in the presence of several lubricating greases including some containing nanometer-sized colloidal silver (Ag) particles. Reciprocating rolling sphere-on-disk experiments were conducted under electro-tribological loads employing polyurea greases derived from mineral and synthetic base oils with and without additives. Friction forces and electrical resistance were monitored continuously during the tests; surface changes were characterized by means of optical spectroscopy, stylus profilometry, and scanning electron microscopy (SEM) including compositional analysis using energy dispersive spectroscopy (EDS). The observations demonstrate that surface pitting induced by arcing occurs mainly at the points were the rolling motion changes direction and that eroded metal is deposited along the wear grove. Micron-sized pits are formed which contain carbon and oxygen indicating that arcing causes decomposition of the hydrocarbon lubricants. Numerous findings indicate a significant inhibition of pitting is induced by the Ag nanoparticles; some greases containing other additives exhibit a similar, although less pronounced, effect.
Semen quality and metabolic profile in people with type 1 diabetes with and without erectile dysfunction: a cross-sectional study
Authors: Longo M. , Caruso P. , Varro C. , Tomasuolo M. , Cirillo P. , Scappaticcio L. , Romano L. , Arcaniolo D. , Maiorino M. I. , Bellastella G. , De Sio M. , Esposito K. 
Published: January 2024

Abstract
Purpose
The aim of the present study is to evaluate the association of metabolic and glycemic variables with semen parameters in patients with type 1 diabetes (T1D) with and without erectile dysfunction (ED).

Methods
The study population included 88 adults with T1D using a continuous glucose monitoring, of whom 28 with ED (ED group) and 60 without it (NO ED group). All men completed the International Index of Erectile Function (IIEF-5) and underwent body composition analysis (BIA) and semen analysis.

Results
ED group showed worse HbA1c levels [median (IQR), 8.4 (7.7, 9.9) vs 7.4 (7, 8.2) %, P < 0.001)], higher insulin dose [60 (51, 65) vs 45 (38, 56) UI/die, P = 0.004)] and a higher total body water and intracellular water as compared with ED group. Men in the ED group presented higher semen volume [2.8 (2.6, 4.2) vs 2.5 (2.2, 2.7) mL, P < 0.001] and sperm concentration [24 (19, 29) vs 20 (12, 23) mil/mL, P = 0.010], but reduced sperm progressive motility [28 (25, 35) vs 35 (25, 36) %, P = 0.011], higher rate of non-progressive motility [15 (10, 15) vs 10 (5, 10) %, P < 0.001] and higher rate of typical morphology [7(5, 8) vs 5 (4, 5) %, P = 0.001]. Based on multivariate logistic regression analysis performed to assess the association between clinical variables and ED, intracellular water (OR 3.829, 95% CI 1.205, 12.163, P = 0.023) resulted as the only independent predictor of ED.

Conclusion
Men with T1D and ED showed worse metabolic profile which is associated with poor semen quality, as compared with those without ED.
Three dimensional discrete element modelling of the conventional compression behavior of gas hydrate bearing coal
Authors: Gao Xia , Wang Nannan , Zhang Baoyong , Lin Qiqi , Wu Qiang , Meng Wei , Liu Xia 
Published: January 2024

AbstractTo analyze the relationship between macro and meso parameters of the gas hydrate bearing coal (GHBC) and to calibrate the meso-parameters, the numerical tests were conducted to simulate the laboratory triaxial compression tests by PFC3D, with the parallel bond model employed as the particle contact constitutive model. First, twenty simulation tests were conducted to quantify the relationship between the macro–meso parameters. Then, nine orthogonal simulation tests were performed using four meso-mechanical parameters in a three-level to evaluate the sensitivity of the meso-mechanical parameters. Furthermore, the calibration method of the meso-parameters were then proposed. Finally, the contact force chain, the contact force and the contact number were examined to investigate the saturation effect on the meso-mechanical behavior of GHBC. The results show that: (1) The elastic modulus linearly increases with the bonding stiffness ratio and the friction coefficient while exponentially increasing with the normal bonding strength and the bonding radius coefficient. The failure strength increases exponentially with the increase of the friction coefficient, the normal bonding strength and the bonding radius coefficient, and remains constant with the increase of bond stiffness ratio; (2) The friction coefficient and the bond radius coefficient are most sensitive to the elastic modulus and the failure strength; (3) The number of the force chains, the contact force, and the bond strength between particles will increase with the increase of the hydrate saturation, which leads to the larger failure strength.
Reproductive Outcomes of Conventional In Vitro Fertilization and Intracytoplasmic Sperm Injection in Patients with Non-Severe Male Infertility Across Poor and Different Sub-Optimal Ovarian Response Categories: A Cohort Study Based on 30,352 Fresh Cycles from 2009–2019
Authors: Jiesisibieke Dina , Tian Tian , Zhu Xiaxuan , Fang Shilin , Zhang Nan , Ma Jinxi , Xia Yuqi , Li Rong , Liu Ping , Qiao Jie , Yang Rui 
Published: January 2024

AbstractDue to the influence of economic, social and many other factors, there are more and more reproductive problems. Originally introduced for managing male factor infertility, intracytoplasmic sperm injection had become the most commonly used fertilization treatment in the world, with broadened indications including low oocyte yield, prior fertilization failure with conventional in vitro fertilization etc. However, academic evidence for better live-birth outcomes of intracytoplasmic sperm injection over conventional in vitro fertilization is limited. Thus, we aimed to compare the reproductive outcomes of conventional in vitro fertilization and intracytoplasmic sperm injection in patients with non-severe male factor infertility across poor and different sub-optimal ovarian response categories. The fertility rate, implantation rate, clinical pregnancy rate, live birth rate and other obstetric outcomes were mainly compared. Our results showed that independent of the number of oocytes retrieved, intracytoplasmic sperm injection significantly increased the fertilization rate, while conventional in vitro fertilization cycles showed a higher implantation rate, clinical pregnancy rate, and live birth rate. No differences were observed in most obstetric outcomes. Our study indicates that poor ovarian response is not an indication for intracytoplasmic sperm injection in couples with non-severe male infertility.
Aromatase inhibition using Juniperus procera phytochemical constituents: molecular docking study
Authors: Al-Zahrani Ateeq Ahmed 
Published: January 2024

AbstractThe key step in the biosynthesis of estrogen is the enzyme activity of aromatase. Several malignancies, including breast cancer, have been linked to the initiation and progression of estrogen overexpression. Exemestane, Arimidex and Femara are the most common aromatase inhibitors used to treat hormone-dependent breast cancers. Drug resistance and side effects are commonly associated with these treatments. The purpose of this in silico study was to list the chemical compounds of Juniperus procera that have been published in scientific papers. The second goal was to evaluate the inhibitory activity of 124 phytochemicals of Juniperus procera compared to known aromatase inhibitors such as Exemestane, Arimidex and Femara. The 3D structure of aromatase (PDB id: 3s7s) employed for docking studies using AutoDock Tools as well as normal mode analysis studies utilizing the NMSim web server. Juniperolide, Kaurenoic acid and Isocupressic acid were identified as competitive aromatase inhibitors compared to FDA approved anti-cancer drugs, specifically Exemestane, Arimidex and Femara. The stability of the ligand–protein interface was studied to support the docking findings. To our knowledge, this is the first study that investigates the possible inhibition roles of some compounds of Juniperus procera on the aromatase enzyme.
Commentary on ‘Institutional Logics: Motivating Action and Overcoming Resistance to Change’
Authors: Redding Gordon 
Published: January 2024

AbstractThis commentary applauds Haveman, Joseph-Goteiner, and Li's (2023) efforts to build arguments around institutional logics to explain China’s remarkable economic progress since 1978. But it also calls for broadening the focus of this inquiry so it can more generally explain why and how some societies are able to build connections between cultures and institutions that enable widespread societal progress, while other countries fail to do so. In particular, I suggest that this line of inquiry would benefit from drawing more deeply on the extensive body of writings by economic historians who have compared the economic progress of different societies over a long period.
Milk fat globule membrane: formation and transformation
Authors: Wooding F. B. Peter , Kinoshita Masanao 
Published: January 2024

AbstractThe milk fat globule membrane (MFGM) is formed by complex cell biological processes in the lactating mammary epithelial cell which result in the release of the milk fat globule (MFG) into the secretory alveolus. The MFG is bounded by a continuous unit membrane (UM), separated from the MFG lipid by a thin layer of cytoplasm. This unique apocrine secretion process has been shown in all of the mammary species so far investigated. Once the MFG is released into the alveolus there is a considerable transformation of the UM with its attached cytoplasm. This is the MFGM. The transformation is stable and expressed milk shows the same transformed MFGM structure. Again, this transformation of structure is common to all mammalian species so far investigated. However, the explanation of the transformation very much depends on the method of investigation. Transmission electron microscope (TEM) studies suggest a literal breakdown to a discontinuous UM plus cytoplasm in patches and strands, whereas more recent confocal laser scanning light microscopy (CLSM) studies indicate a separation, in a continuous UM, of two phases, one liquid ordered and the other liquid disordered. This review is designed to show that the TEM and CLSM results show different views of the same structures once certain deficiencies in techniques are factored in.
The Decreased Cloud Cover Dominated the Rapid Spring Temperature Rise in Arid Central Asia Over the Period 1980–2014
Authors: Wang Gongxin , Yuan Xiuliang , Jing Changqing , Hamdi Rafiq , Ochege Friday Uchenna , Dong Ping , Shao Yuqing , Qin Xueyan 
Published: January 2024

AbstractCentral Asia (CA) has experienced a faster temperature rise than the global land over the past decades. However, the role of regional/global drivers and their associated underlying biophysical mechanisms is poorly explored. Here, we combined observations and model simulations to show that the rapid warming in CA was overwhelmingly contributed by rapid spring warming (i.e., 49.23%). The decrease of cloud cover (CLD) was the main driver of spring warming in CA, leading to the surface receiving more solar radiation, consequently heating the surface air temperature, and contributing almost 40.79% to the spring warming. Besides, the strengthening of sea level pressure states results in continuous subsidence of vertical motion over CA, which was unfavorable for cloud formation. Our study will deepen our understanding of the climate evolution in the arid CA.
Multi‐Proxy Evidence for Atlantic Meridional Overturning Circulation (AMOC) Weakening During Deglaciations of the Past 150,000 Years
Authors: Garity Monica , Lund David 
Published: January 2024

AbstractDespite decades of research, the cause of deglaciations is not fully understood, leaving a critical gap in our understanding of Earth's climate system. During the most recent deglaciation (Termination I (T I)), abrupt declines in the stable carbon isotope ratio (δ13C) of benthic foraminifera occurred throughout the mid‐depth (1,500–2,500 m) Atlantic. The spatial pattern in δ13C anomalies was likely due to Atlantic Meridional Overturning Circulation (AMOC) weakening and the accumulation of respired carbon, which also yields negative excursions in carbonate ion concentration (). To investigate whether a similar pattern occurred during prior deglaciations, we developed δ13C and records from 1,800 and 2,300 m water depth in the Southwest Atlantic spanning the last 150 ka. The new records reveal negative δ13C and anomalies during Termination II (TII) and the smaller deglaciations of Marine Isotope Stages (MIS) 4/3, 5b/a, and 5d/c, suggesting AMOC weakening is a common feature of deglaciation. The anomalies are more pronounced in the shallower core following MIS 2, 4, and 6 and in the deeper core following MIS 5b and 5d. The depth‐dependent pattern is most likely due to shoaling of Northern Source Water during glacial maxima and deepening during interglacial intervals. Comparison of records from TI and TII suggests similar levels of carbon accumulation in the mid‐depth Atlantic. The Brazil Margin δ13C and results indicate the AMOC plays a key role in the series of events causing deglaciation, regardless of differences in orbital configuration, ice volume, and mean global temperature.
An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
Authors: McEwan Andrew R. , Hing Benjamin , Erickson Johanna C. , Hutchings Greg , Urama Charity , Norton-Hughes Emily , D’Ippolito Mariam , Berry Susan , Delibegovic Mirela , Grassmann Felix , MacKenzie Alasdair 
Published: January 2024

AbstractObesity and anxiety are morbidities notable for their increased impact on society during the recent COVID-19 pandemic. Understanding the mechanisms governing susceptibility to these conditions will increase our quality of life and resilience to future pandemics. In the current study, we explored the function of a highly conserved regulatory region (BE5.1) within the BDNF gene that harbours a polymorphism strongly associated with obesity (rs10767664; p = 4.69 × 10–26). Analysis in primary cells suggested that the major T-allele of BE5.1 was an enhancer, whereas the obesity-associated A-allele was not. However, CRISPR/CAS9 deletion of BE5.1 from the mouse genome (BE5.1KO) produced no significant effect on the expression of BDNF transcripts in the hypothalamus, no change in weight gain after 28 days and only a marginally significant increase in food intake. Nevertheless, transcripts were significantly increased in the amygdala of female mice and elevated zero maze and marble-burying tests demonstrated a significant increase in anxiety-like behaviour that could be reversed by diazepam. Consistent with these observations, human GWAS cohort analysis demonstrated a significant association between rs10767664 and anxiousness in human populations. Intriguingly, interrogation of the human GTEx eQTL database demonstrated no effect on BDNF mRNA levels associated with rs10767664 but a highly significant effect on BDNF-antisense (BDNF-AS) gene expression and splicing. The subsequent observation that deletion of BE5.1 also significantly reduced BDNF-AS expression in mice suggests a novel mechanism in the regulation of BDNF expression common to mice and humans, which contributes to the modulation of mood and anxiety in both species.
ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling
Authors: He Ying , Shi Qian , Ling Yuhang , Guo Huihui , Fei Yi , Wu Ruoyu , Tang Chengwu , Zhang Xilin , Yao Linhua 
Published: January 2024

AbstractActin-binding LIM protein 1 (ABLIM1), a member of the LIM-domain protein family, has been reported as a suppressor in several tumors whereas its role in colorectal cancer (CRC) remains unknown. In this study, we find that ABLIM1 is up-regulated in CRC patients and high levels of ABLIM1 predict short disease-free survival time. Knock-down of ABLIM1 in CRC cell lines by lenti-virus leads to inhibited cell proliferation, migration, and invasion capabilities in vitro and impaired growth of tumor xenografts and liver metastasis lesions in vivo, while ABLIM1 overexpression accelerates tumor growth and invasion in vitro. Mechanistically, we uncover that ABLIM1 activates the NF-ĸB/CCL-20 signaling through modulating IĸBα ubiquitination and proteasomal-mediated degradation. Further co-immunoprecipitation, in vivo and in vitro ubiquitination assays reveal ABLIM1 as a novel ubiquitin E3 ligase binding to IĸBα. Interestingly, The E3 ligase catalysis activity of ABLIM1 depends on its 402–778aa rather than its LIM domains and its interaction with IĸBα relies on the HP domain. Our findings delineate the oncogenic role of ABLIM1 in CRC progression and reveal it as a novel E3 ligase targeting IĸBα, providing new insights into the regulation of NF-ĸB signaling in tumors.
Recent progress in photoinduced transitions between the solid, glass, and liquid states based on molecular photoswitches
Authors: Imato Keiichi , Kaneda Naoki , Ooyama Yousuke 
Published: January 2024

AbstractPhotoinduced transitions between the solid, glass, and liquid states based on molecular photoswitches promise a wide variety of applications. Photoswitchable adhesives are representative examples and are expected to contribute to material recycling for a sustainable future in the era of composite materials due to strong bonding and on-demand photo-induced debonding with minimal damage to the adherends. Only a few molecular photoswitches are known to undergo these transitions, but recent progress, mainly with azobenzene, has been remarkable. Here, we review the photoinduced transitions of small molecules and polymers over approximately a decade and systematically discuss the molecular designs, mechanisms, applications, merits and demerits, and future challenges in each photoswitch and the whole field. We hope this review provides useful information, inspiration, and ideas for the development of this field and the expansion of its applications.