bluuebunny/crossref_metadata_2025_split huggingface dataset:
circMSH3 is a potential biomarker for the diagnosis of colorectal cancer and affects the distant metastasis of colorectal cancer
Authors: Shen Jian , Min Yu , Luo Jingen , Tang Xingkui , Han Zeping , Luo Wenfeng , Xie Fangmei , Cao Mingrong , Zhou Taicheng , He Jinhua 
Published: November 2023

Objectives
To identify the most significantly differentially expressed circular RNAs (circRNAs) in colorectal cancer (CRC) tissues in terms of their expression levels and circularity, and to analyze the relationship between their expression levels and the clinical characteristics of patients.

Methods
circRNA RNA-seq technology was used to screen differentially expressed circRNAs in CRC. Sanger sequencing was used to identify circRNA back-splice junction sites. The relative expression levels of hsa_circ_0003761 (circMSH3) in CRC tissues and cell lines were detected by quantitative real-time fluorescence PCR technology. An RNA-protein pull-down assay was used to detect protein binding to circRNAs. Dual-luciferase reporter gene vectors were constructed to verify that circRNAs bind to microRNAs.

Results
Four hundred twenty circRNAs were found to be upregulated, and 616 circRNAs were downregulated. circMSH3 was derived from the MutS homolog 3 (MSH3) gene and was formed by a loop of exons 9, 10, 11, and 12. In 110 pairs of CRC and adjacent tissues, circMSH3 expression was 4.487-fold higher in CRC tissues. circMSH3 was also highly expressed in the HT-29 and LOVO CRC cell lines. The expression level of circMSH3 was associated with distant metastasis in CRC patients (P = 0.043); the area under the curve (AUC) of circMSH3 for CRC diagnosis was 0.75, with a sensitivity and specificity of 70.9% and 66.4%, respectively. circMSH3 could bind to a variety of proteins, mainly those involved in RNA transcription, splicing, cell cycle, and cell junctions. Furthermore, circMSH3 could bind to miR-1276, miR-942-5p, and miR-409-3p.

Conclusion
circMSH3 is a potential biomarker for the diagnosis of CRC and affects the distant metastasis of CRC. Multiple RNA-binding protein binds to circMSH3, and circMSH3 binds to miR-1276, miR-942-5p, and miR-409-3p, thereby affecting the expression of circMSH3.
Association of triglyceride-glucose index with the risk of prostate cancer: a retrospective study
Authors: Li Tianqi , Zhou Yijie , Wang Jinru , Xiao Songtao , Duan Yajun , Li Caihong , Gao Yi , An Hengqing , Tao Ning 
Published: November 2023

Background
Prostate cancer is the most common malignancy in men, and its incidence is increasing year by year. Some studies have shown that risk factors for prostate cancer are related to insulin resistance. The triglyceride-glucose (TyG) index is a marker of insulin resistance. We investigated the validity of TyG index for predicting prostate cancer and the dose-response relationship in prostate cancer in relation to it.

Objective
To investigate the risk factors of TyG index and prostate cancer prevalence.

Methods
This study was screened from the First Affiliated Hospital of Xinjiang Medical University and included 767 people, including 136 prostate cancer patients in the case group and 631 healthy people in the control group. The relationship between TyG index and the risk of prostate cancer was analyzed by one-way logistic regression, adjusted for relevant factors, and multi-factor logistic regression analysis was performed to further investigate the risk factors affecting the prevalence of prostate cancer. ROC curves and Restricted Cubic Spline were established to determine the predictive value and dose-response relationship of TyG index in prostate cancer.

Results
Blood potassium (OR = 0.056, 95% CI [0.021–0.148]), total cholesterol (OR = 1.07, 95% CI [0.792–1.444]) and education level (OR = 0.842, 95% CI [0.418–1.697]) were protective factors for prostate cancer, alkaline phosphatase, age, LDL, increased the risk of prostate cancer (OR = 1.016, 95% CI [1.006–1.026]) (OR = 139.253, 95% CI [18.523–1,046.893] (OR = 0.318, 95% CI [0.169–0.596]); TyG index also was a risk factor for prostate cancer, the risk increased with TyG levels,and persons in the TyGQ3 group (8.373–8.854 mg/dL) was 6.918 times (95% CI [2.275–21.043]) higher than in the Q1 group,in the TyGQ4 group (≥8.854) was 28.867 times of those in the Q1 group (95% CI [9.499–87.727]).

Conclusion
TyG index may be a more accurate and efficient predictor of prostate cancer.
Deep‐neural network approaches for predicting 3D dose distribution in intensity‐modulated radiotherapy of the brain tumors
Authors: Irannejad Maziar , Abedi Iraj , Lonbani Vida Darbaghi , Hassanvand Maryam 
Published: November 2023

AbstractPurposeThe aim of this study is to reduce treatment planning time by predicting the intensity‐modulated radiotherapy 3D dose distribution using deep learning for brain cancer patients. “For this purpose, two different approaches in dose prediction, i.e., first only planning target volume (PTV) and second PTV with organs at risk (OARs) as input of the U‐net model, are employed and their results are compared.”Methods and MaterialsThe data of 99 patients with glioma tumors referred for IMRT treatment were used so that the images of 90 patients were regarded as training datasets and the others were for the test. All patients were manually planned and treated with sixth‐field IMRT; the photon energy was 6MV. The treatment plans were done with the Collapsed Cone Convolution algorithm to deliver 60 Gy in 30 fractions.ResultsThe obtained accuracy and similarity for the proposed methods in dose prediction when compared to the clinical dose distributions on test patients according to MSE, dice metric and SSIM for the Only‐PTV and PTV‐OARs methods are on average (0.05, 0.851, 0.83) and (0.056, 0.842, 0.82) respectively. Also, dose prediction is done in an extremely short time.ConclusionThe same results of the two proposed methods prove that the presence of OARs in addition to PTV does not provide new knowledge to the network and only by defining the PTV and its location in the imaging slices, does the dose distribution become predictable. Therefore, the Only‐PTV method by eliminating the process of introducing OARs can reduce the overall designing time of treatment by IMRT in patients with glioma tumors.
Clinical importance of changes in magnetic resonance biomarkers for Duchenne muscular dystrophy
Authors: Willcocks Rebecca J. , Barnard Alison M. , Daniels Michael J. , Forbes Sean C. , Triplett William T. , Brandsema John F. , Finanger Erika L. , Rooney William D. , Kim Sarah , Wang Dah‐Jyuu , Lott Donovan J. , Senesac Claudia R. , Walter Glenn A. , Sweeney H. Lee , Vandenborne Krista 
Published: November 2023

AbstractObjectiveMagnetic resonance (MR) measures of muscle quality are highly sensitive to disease progression and predictive of meaningful functional milestones in Duchenne muscular dystrophy (DMD). This investigation aimed to establish the reproducibility, responsiveness to disease progression, and minimum clinically important difference (MCID) for multiple MR biomarkers at different disease stages in DMD using a large natural history dataset.MethodsLongitudinal MR imaging and spectroscopy outcomes and ambulatory function were measured in 180 individuals with DMD at three sites, including repeated measurements on two separate days (within 1 week) in 111 participants. These data were used to calculate day‐to‐day reproducibility, responsiveness (standardized response mean, SRM), minimum detectable change, and MCID. A survey of experts was also performed.ResultsMR spectroscopy fat fraction (FF), as well as MR imaging transverse relaxation time (MRI‐T2), measures performed in multiple leg muscles, and had high reproducibility (Pearson's R > 0.95). Responsiveness to disease progression varied by disease stage across muscles. The average FF from upper and lower leg muscles was highly responsive (SRM > 0.9) in both ambulatory and nonambulatory individuals. MCID estimated from the distribution of scores, by anchoring to function, and via expert opinion was between 0.01 and 0.05 for FF and between 0.8 and 3.7 ms for MRI‐T2.InterpretationMR measures of FF and MRI T2 are reliable and highly responsive to disease progression. The MCID for MR measures is less than or equal to the typical annualized change. These results confirm the suitability of these measures for use in DMD and potentially other muscular dystrophies.
Phase‐Controlled Growth of 1T′‐MoS2 Nanoribbons on 1H‐MoS2 Nanosheets
Authors: Wang Yongji , Zhai Wei , Ren Yi , Zhang Qinghua , Yao Yao , Li Siyuan , Yang Qi , Zhou Xichen , Li Zijian , Chi Banlan , Liang Jinzhe , He Zhen , Gu Lin , Zhang Hua 
Published: November 2023

Abstract2D heterostructures are emerging as alternatives to conventional semiconductors, such as silicon, germanium, and gallium nitride, for next‐generation electronics and optoelectronics. However, the direct growth of 2D heterostructures, especially for those with metastable phases still remains challenging. To obtain 2D transition metal dichalcogenides (TMDs) with designed phases, it is highly desired to develop phase‐controlled synthetic strategies. Here, a facile chemical vapor deposition method is reported to prepare vertical 1H/1T′ MoS2 heterophase structures. By simply changing the growth atmosphere, semimetallic 1T′‐MoS2 can be in situ grown on the top of semiconducting 1H‐MoS2, forming vertical semiconductor/semimetal 1H/1T′ heterophase structures with a sharp interface. The integrated device based on the 1H/1T′ MoS2 heterophase structure displays a typical rectifying behavior with a current rectifying ratio of ≈103. Moreover, the 1H/1T′ MoS2‐based photodetector achieves a responsivity of 1.07 A W−1 at 532 nm with an ultralow dark current of less than 10−11 A. The aforementioned results indicate that 1H/1T′ MoS2 heterophase structures can be a promising candidate for future rectifiers and photodetectors. Importantly, the approach may pave the way toward tailoring the phases of TMDs, which can help us utilize phase engineering strategies to promote the performance of electronic devices.
Recent Advances in Multi‐Photon 3D Laser Printing: Active Materials and Applications
Authors: Mainik Philipp , Spiegel Christoph A. , Blasco Eva 
Published: November 2023

AbstractSince the pioneering work of Kawata and colleagues in 1997, multi‐photon 3D laser printing, also known as direct laser writing, has made significant advancements in a wide range of fields. Moreover, the development and commercialization of photocurable inks for this technique have expanded rapidly. One of the current trends is the transition from static to active printable materials, often referred to as 4D microprinting, which enables a new degree of control in the printed systems. This review focuses on four primary application areas: microrobotics, optics and photonics, microfluidics, and life sciences, highlighting recent progress and the crucial role of active materials, including liquid crystalline elastomers, hydrogels, shape memory polymers, and composites, among others. It also addresses ongoing challenges and provides insights into the future prospects in the different fields.
Calloso‐adreno‐scrotal agenesis associated with biallelic MAPK‐activating death domain protein (MADD) variant: Further phenotypic delineation of MADD deficiency
Authors: Darouich Sihem , Darouich Samia 
Published: November 2023

AbstractMAPK‐activating death domain protein (MADD) deficiency is associated with a broad clinical spectrum ranging from mild developmental impairment to fatal multisystem disorder. We report an additional case of severe form with some overlapping and unreported systemic features in a growth‐restricted full‐term male newborn. The novel findings include corpus callosum agenesis, bilateral adrenal agenesis, scrotal aplasia, and abnormal skin pigmentation. Microscopic changes are only remarkable in thyroid gland that shows decreased, variously sized follicles with absent or non‐vacuolated pale colloid. This unique constellation of birth defects is associated with a novel homozygous in‐frame MADD gene deletion (NM_003682.4: c.4853_4855delGCT:p.Cys1618del). This case report expands the phenotypic and genetic spectrum of MADD deficiency.
Bicyclic Guanidine Promoted Mechanistically Divergent Depolymerization and Recycling of a Biobased Polycarbonate
Authors: Lamparelli David H. , Villar‐Yanez Alba , Dittrich Lorenz , Rintjema Jeroen , Bravo Fernando , Bo Carles , Kleij Arjan W. 
Published: November 2023

AbstractWe here report the organocatalytic and temperature‐controlled depolymerization of biobased poly(limonene carbonate) providing access to its trans‐configured cyclic carbonate as the major product. The base TBD (1,5,7‐triazabicyclo[4.4.0]dec‐5‐ene) offers a unique opportunity to break down polycarbonates via end‐group activation or main chain scission pathways as supported by various controls and computational analysis. These energetically competitive processes represent an unprecedented divergent approach to polycarbonate recycling. The trans limonene carbonate can be converted back to its polycarbonate via ring‐opening polymerization using the same organocatalyst in the presence of an alcohol initiator, offering thus a potential circular and practical route for polycarbonate recycling.
Cu3BiS3: Two‐Dimensional Coordination Induces Out‐of‐Plane Phonon Scattering Enabling Ultralow Thermal Conductivity
Authors: Jia Fei , Zhao Shuang , Wu Jing , Chen Ling , Liu Te‐Huan , Wu Li‐Ming 
Published: November 2023

AbstractThe discovery of compounds with low thermal conductivity and the understanding of their microscopic mechanisms are of great challenges and scientific significance. Herein, we report a unique ternary sulfide compound, Cu3BiS3, in which all Cu atoms are coordinated within a two‐dimensional [CuS3] triangle plane. This local coordination leads to efficient out‐of‐plane phonon scattering and an ultralow thermal conductivity. Through DFT phonon spectrum calculations and analyses, we reveal that the lowest vibration frequency decreases from 2 THz for high‐dimensional [CuS4] tetrahedral coordinated Cu atoms in CuBiS2 (CN=4, with an average Cu−S bond length of 2.328 Å) to 1.5 THz for low‐dimensional [CuS3] triangular coordinated Cu atoms in Cu3BiS3 (CN=3, with a shorter Cu−S bond length of 2.285 Å). This is due to the out‐of‐plane thermal vibration of the Cu atoms in the latter. Consequently,Cu3BiS3 exhibits one of the lowest values of κlat (0.32 W/m K) among its peer, with a 36 % reduction compared to CuBiS2 (0.50 W/m K). This groundbreaking discovery highlights the significant role of 2D local coordination in reducing thermal conductivity through characteristic out‐of‐plane phonon scattering, while also contributing to a large Grüneisen parameter (2.06) in Cu3BiS3.
Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells
Authors: Abdelsalam Mohamed , Zmyslia Mariia , Schmidtkunz Karin , Vecchio Anita , Hilscher Sebastian , Ibrahim Hany S. , Schutkowski Mike , Jung Manfred , Jessen‐Trefzer Claudia , Sippl Wolfgang 
Published: November 2023

AbstractAlthough histone deacetylase (HDAC) inhibitors show promise in treating various types of hematologic malignancies, they have some limitations, including poor pharmacokinetics and off‐target side effects. Prodrug design has shown promise as an approach to improve pharmacokinetic properties and to improve target tissue specificity. In this work, several bioreductive prodrugs for class I HDACs were designed based on known selective HDAC inhibitors. The zinc‐binding group of the HDAC inhibitors was masked with various nitroarylmethyl residues to make them substrates of nitroreductase (NTR). The developed prodrugs showed weak HDAC inhibitory activity compared to their parent inhibitors. The prodrugs were tested against wild‐type and NTR‐transfected THP1 cells. Cellular assays showed that both 2‐nitroimidazole‐based prodrugs 5 and 6 were best activated by the NTR and exhibited potent activity against NTR‐THP1 cells. Compound 6 showed the highest cellular activity (GI50 = 77 nM) and exhibited moderate selectivity. Moreover, activation of prodrug 6 by NTR was confirmed by liquid chromatography‐mass spectrometry analysis, which showed the release of the parent inhibitor after incubation with Escherichia coli NTR. Thus, compound 6 can be considered a novel prodrug selective for class I HDACs, which could be used as a good starting point for increasing selectivity and for further optimization.
Clinical and procedural outcomes of percutaneous coronary intervention for de novo lesions involving the ostial left circumflex coronary artery
Authors: Cozzi Ottavia , Maurina Matteo , Cacia Michele , Bernardini Valentina , Gohar Aisha , Cao Davide , Mangieri Antonio , Condello Francesco , Leone Pier Pasquale , Sticchi Alessandro , Rossi Marco L. , Gasparini Gabriele , Stefanini Giulio G. , Condorelli Gianluigi , Reimers Bernhard , Colombo Antonio , Regazzoli Damiano 
Published: November 2023

AbstractBackgroundPercutaneous treatment for ostial left circumflex artery (LCx) lesions is known to be associated with suboptimal results.AimsThe present study aims to assess the procedural and long‐term clinical outcomes of percutaneous coronary intervention (PCI) for de novo ostial LCx lesions overall and according to the coronary revascularization strategy.MethodsConsecutive patients undergoing PCI with second generation drug eluting stents or drug coated balloons for de novo ostial LCx lesions in three high‐volume Italian centers between 2012 and 2021 were retrospectively evaluated. The primary endpoint was target‐vessel revascularization (TVR) at 2 years. Secondary endpoints included major adverse cardiovascular and cerebrovascular events (MACCE), target lesion revascularization, myocardial infarction, stroke, all‐cause death, and repeat revascularization.ResultsA total of 366 patients were included in the analysis with a median follow‐up of 901 (IQR: 450−1728) days. 79.5% of the patients were male, 33.6% were diabetic, 49.7% had a previous PCI, and 23.1% a prior surgical revascularization. Very ostial LCx stenting was performed in 34.1%, crossover from left main to LCx in 17.3%, and a two‐stent strategy in 48.6% of cases, respectively. In the overall population, the incidence of TVR at 2 years was 19.0% while MACCE rate was 25.7%. No major differences in clinical outcomes were found according to the stenting strategy. Use of intracoronary imaging was associated with fewer MACCE (HR: 0.47, 95% CI: 0.25−1.13, p = 0.01), while the diameter of the stent implanted in the ostial LCx was associated with less TVR (HR: 0.43, 95% CI: 0.25−0.75, p = 0.002).ConclusionsPercutaneous revascularization of the ostial LCx is associated with a high rate of TVR, regardless of the stenting strategy. Intracoronary imaging and proper stent sizing may reduce the failure rates.
On the Structure Insensitivity of Propane Total Oxidation over Pt/CeO2: A Comparison between Single Atoms, Clusters and Nanoparticles
Authors: Gao Biwen , Zhang Kefeng , Wang Yu , Lu Jiqing , Liu Pengxin 
Published: November 2023

AbstractA series of Pt/CeO2 catalysts with varied sizes of Pt domains are prepared and evaluated in propane total oxidation reaction, to investigate the structural sensitivity regarding the particle sizes and metal‐support interactions. Over Pt single atoms, clusters or nanoparticles (NP), the obtained similar turnover frequencies and apparent activation energies suggest the reaction is structure insensitive to the sizes of Pt domains. Nonetheless, detailed kinetic study reveals different adsorption behavior of reactants (C3H8 and O2) over these Pt species. Following a Langmuir‐Hinshelwood mechanism, C3H8 and O2 competitively adsorb on Pt surface. The adsorption of C3H8 and O2 on Pt single atom is much easier than on Pt nanoparticles due to its lower coordination. These findings provide experimental evidences for the reaction behavior of C3H8 oxidation over Pt/CeO2 catalysts, and lay a foundation for further understanding of the structure‐property relationship.
TiO2−CeOx−Pt Hollow Nanosphere Catalyst for Low‐Temperature CO Oxidation
Authors: Liebertseder Mareike , Maliakkal Carina B. , Crone Marlene , Nails Gülperi , Casapu Maria , Grunwaldt Jan‐Dierk , Türk Michael , Kübel Christian , Feldmann Claus 
Published: November 2023

AbstractTiO2−CeO2−Pt hollow nanospheres (1 wt‐% Pt) are realized using a liquid‐phase strategy using NaCl as a template. The NaCl template is first coated with TiO2 and thereafter with CeO2 via the hydrolyzation of TiCl(OiPr)3 and Ce(OiPr)4 as suitable alkoxides. Finally, the NaCl template is removed by washing with water. The resulting @TiO2−CeO2 hollow nanospheres (□: inner cavity) exhibit an outer diameter of 140–180 nm, a wall thickness of 30–40 nm, an inner cavity of 80–100 nm, a specific surface area of 210 m2/g, a pore volume and area of 0.08 cm3/g and 191 m2/g, mainly with micropores ≥5 Å and ≤14 Å. The hollow nanosphere support is impregnated with Pt nanoparticles, using two different methods – a wet‐chemical deposition (Pt(ac)2, acetone, 25 °C) and a supercritical fluid reactive deposition (SFRD) process ([Pt(COD)Me2], supercritical CO2, 80 °C, 15.6 MPa) resulting in an uniform size distribution with Pt nanoparticles 2.5±0.1 nm (TiO2−CeO2−PtWCD) and 2.3±0.1 nm (TiO2−CeO2−PtSFRD) in size. The catalytic properties of the TiO2−CeO2−Pt hollow nanospheres are evaluated for CO oxidation between 50 and 500 °C. A promising catalytic activity and stable light‐out/light‐off temperatures are observed especially for the TiO2−CeO2−PtSFRD sample, indicating the suitability of hollow nanospheres as high‐porosity catalyst material.
Chiral‐at‐Metal Racemization Unraveled for MX2(a‐chel)2 by Means of a Computational Analysis of MoO2(acnac)2
Authors: Dhimba George , Muller Alfred , Lammertsma Koop 
Published: November 2023

AbstractInvited for the cover of this issue are Koop Lammertsma and co‐workers at the University of Johannesburg and Vrije Universiteit Amsterdam. The image of the kudu's antlers depicts the isomerization and racemization of the chiral‐at‐metal complex MoO2(acnac)2 (acnac=β‐ketoiminate). Read the full text of the article at 10.1002/chem.202302516.