bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term followup of health status in patients with severe rheumatoid arthritis after high‐dose chemotherapy followed by autologous hematopoietic stem cell transplantation
Authors: Teng Y. K. O. , Verburg R. J. , Sont J. K. , Van Den Hout W. B. , Breedveld F. C. , Van Laar J. M. 
Published: July 2005

AbstractObjectiveHigh‐dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (HSCT) is a new treatment for patients with severe, refractory rheumatoid arthritis (RA). The present study was undertaken to assess the health status of patients with severe RA over a long‐term followup period after treatment with HDC + HSCT.MethodsHealth status and utility scores were assessed in 8 patients before and after treatment with HDC + HSCT. Patients were followed up for 5 years posttransplantation. Health status was assessed by the Health Assessment Questionnaire (HAQ), the RAND‐36 version of the Short Form 36 (SF‐36) health survey, and the Arthritis Impact Measurement Scales (AIMS). Utility scores were calculated using the EuroQol (EQ‐5D) questionnaire and the SF‐36–derived utility index (called the SF‐6D), from which quality‐adjusted life years (QALYs) were derived.ResultsMost measures of health status improved compared with baseline in the first 2 years posttransplantation, notably HAQ and AIMS scores and scores on the functional status, general health, and health change summary scales of the RAND‐36 version of the SF‐36. Utility scores derived from the EQ‐5D questionnaire and the SF‐6D also increased significantly after transplantation. This was reflected in the 0.28 QALYs gained compared with baseline. For a putative 50‐year‐old RA patient with a life expectancy of 20 years, a threshold analysis revealed that HDC + HSCT yielded more QALYs than conventional therapy when treatment‐related mortality (TRM) was <2.8%.ConclusionHDC + HSCT temporarily increased the functionality and health status of patients with severe, refractory RA. With a reported TRM of 1.3%, HDC + HSCT can be considered a realistic treatment option for patients with severe RA.
Increased radiographic damage scores at the onset of seropositive rheumatoid arthritis in older patients are associated with osteoarthritis of the hands, but not with more rapid progression of damage
Authors: Khanna Dinesh , Ranganath Veena K. , FitzGerald John , Park Grace S. , Altman Roy D. , Elashoff David , Gold Richard H. , Sharp John T. , Furst Daniel E. , Paulus Harold E. 
Published: July 2005

AbstractObjectiveTo investigate the impact of patient age at symptom onset on radiographic joint damage at study entry, and on subsequent progression of damage in a cohort of patients with early seropositive rheumatoid arthritis (RA).MethodsWe studied 186 patients with RA of <15 months' duration. All patients had active disease and had not received disease‐modifying antirheumatic drugs. At study entry and during followup, total Sharp scores (TSS), RA‐associated joint space narrowing (RA‐JSN), and erosions were determined on hand and foot radiographs. Baseline radiographs were also scored for osteoarthritis (OA)–related JSN (OA‐JSN) and osteophytes. Older patients (>55 years) and younger patients (≤55 years) were compared by t‐test, Mann‐Whitney U test, chi‐square, or Fisher's exact test. Multiple linear regression models were also constructed.ResultsThe older group (n = 74) had a higher baseline total Sharp score (median 6.21) compared with the younger group (n = 112) (median 2.33) (P = 0.0002). This was mainly due to a higher baseline JSN score in the older group (median 3.96 versus 1.08) and not to differences in erosion score (median 0.91 versus 0.70). Disease activity and duration of RA symptoms were similar in the 2 groups, as were progression rates of the TSS, JSN score, and erosion score. At baseline, 26% of patients had osteophytes, with a prevalence of 13% in the younger age group and 50% in the older group. The presence of OA‐JSN was highly correlated with the presence of osteophytes (r = 0.72). Also, increased age and RA‐JSN were associated with increased severity of osteophytes and OA‐JSN at baseline. Multiple linear regression analysis showed that both age and hand osteophytes contributed to the increase in baseline RA‐JSN score and TSS, but not to erosion score.ConclusionIn a cohort of patients with early RA, an increase in the baseline RA‐JSN score and TSS can be accounted for in part by the presence of hand OA.
Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: Increased t allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease
Authors: Wu Hui , Cantor Rita M. , Graham Deborah S. Cunninghame , Lingren Cecilia M. , Farwell Lisa , Jager Philip L. De , Bottini Nunzio , Grossman Jennifer M. , Wallace Daniel J. , Hahn Bevra H. , Julkunen Heikki , Hebert Lee A. , Rovin Brad H. , Birmingham Dan J. , Rioux John D. , Yu C. Yung , Kere Juha , Vyse Timothy J. , Tsao Betty P. 
Published: July 2005

AbstractObjectiveRecent case–control studies show associations of the minor T allele (of the C1858T single‐nucleotide polymorphism corresponding to the R620W amino acid substitution) of PTPN22 with multiple autoimmune diseases, including systemic lupus erythematosus (SLE). We performed family‐based association studies of this polymorphism in 4 independent cohorts containing SLE patients and their parents and/or other family members.MethodsA total of 2,689 individuals from 902 independent Caucasian families with SLE were genotyped using polymerase chain reaction pyrosequencing (cohorts 1 and 2) and the Sequenom MassArray system (cohorts 3 and 4). The transmission disequilibrium test (TDT) and the pedigree disequilibrium test (PDT) were conducted to assess the evidence of association.ResultsThe 1858 C > T allele frequencies of the parents showed no deviation from Hardy‐Weinberg equilibrium within each cohort. No evidence of preferential transmission of the T allele from heterozygous parents to their affected offspring was observed in each of the 4 cohorts or in the combined sample. Consistent with the TDT result, the PDT analysis revealed no significant association between the T allele and SLE. In 54 of the 661 SLE patients (cohorts 1 and 3) with documented autoimmune thyroid disease, the T allele frequency was higher than in individuals with SLE alone (16.7% versus 8.5%; P = 0.008, odds ratio 2.16 [95% confidence interval 1.25–3.72]).ConclusionThe R620W polymorphism of the PTPN22 gene is not a major risk allele for SLE susceptibility in our sample of Caucasian individuals from northern America, the UK, or Finland, but it appears to be a risk factor for the concurrent autoimmune diseases of autoimmune thyroid disease and SLE.
Enzyme‐linked immunosorbent assay for detection of Anti–RNA polymerase III antibody: Analytical accuracy and clinical associations in systemic sclerosis
Authors: Kuwana Masataka , Okano Yutaka , Pandey Janardan P. , Silver Richard M. , Fertig Noreen , Medsger Thomas A. 
Published: July 2005

AbstractObjectiveWe have recently developed an enzyme‐linked immunosorbent assay (ELISA) for detection of anti–RNA polymerase III (anti–RNAP III) antibody, using a recombinant fragment containing the immunodominant epitope as the antigen source. This study was conducted to assess the analytical accuracy and clinical associations of the anti–RNAP III ELISA in patients with systemic sclerosis (SSc).MethodsTo evaluate analytical sensitivity and specificity of the ELISA, both immunoprecipitation tests and ELISA were used to detect anti–RNAP III antibody in 534 SSc sera from patients at 3 medical centers. Sera from 522 SSc patients and 516 controls, including patients with other connective tissue diseases and blood bank donors, were also evaluated to assess the clinical sensitivity and specificity of the ELISA. Clinical findings in anti–RNAP III antibody–positive SSc patients were compared between patient groups stratified according to anti–RNAP III antibody levels determined by the ELISA.ResultsIn SSc patients, our ELISA showed analytical sensitivity of 91% and analytical specificity of 99% compared with the immunoprecipitation assay (a gold standard for detection of anti–RNAP III antibody). The additional analysis using a large series of SSc and control sera showed that clinical sensitivity and specificity of the ELISA with respect to the diagnosis of SSc were 17% and 98%, respectively. A high level of anti–RNAP III antibody was associated with diffuse cutaneous SSc, higher maximum total skin score, and increased frequency of tendon friction rubs.ConclusionThe anti–RNAP III ELISA is analytically accurate and clinically specific. With this assay, testing for anti–RNAP III antibody can be made routinely available.
The natural history of anteroposterior laxity and its role in knee osteoarthritis progression
Authors: Dayal Nimesh , Chang Alison , Dunlop Dorothy , Hayes Karen , Chang Rowland , Cahue September , Song Jing , Torres Leah , Sharma Leena 
Published: July 2005

AbstractObjectiveTo test the hypotheses that 1) osteoarthritic (OA) knees at more advanced stages have less anteroposterior (AP) laxity compared with OA knees at milder stages, 2) AP laxity decreases over time, and 3) the absence of a decrease in AP laxity is associated with greater progression of medial tibiofemoral OA.MethodsThe study group comprised 230 patients with knee OA (75% women, mean age 64 years, mean body mass index [BMI] 30 kg/m2). At baseline and 18 months, AP laxity was measured (in millimeters of tibial translation, under AP shear loading), and semiflexed AP knee radiographs (with knee position confirmed by fluoroscopy) were obtained. Osteophytes were graded for each compartment, using a scale of 0–4. Disease progression was measured as the amount of medial joint space loss between baseline and followup, using linear regression with generalized estimating equations.ResultsAt baseline, measurements of AP laxity were lower in knees with a Kellgren/Lawrence (K/L) score of 4 (mean ± SD 5.0 ± 2.1 mm) than in those with a K/L score of 0–1 (mean ± SD 7.1 ± 2.6 mm). There was a weak negative correlation between osteophyte grade and AP laxity. In knees with a K/L score of 0–2, AP laxity was slightly lower at 18 months than at baseline. AP laxity at baseline was not a predictor of progression of OA. Knees without a decrease in AP laxity had a greater loss of medial joint space (0.22 mm greater, after adjusting for age, sex, and BMI) than did knees in which laxity decreased.ConclusionAP laxity at baseline is not predictive of progression of OA. Although knees with a K/L score of 4 had less AP laxity than those with a K/L score of 0–1, most of this difference was attributable to the significant difference in AP laxity between knees with a K/L score of 0–1 and knees with a K/L score of 2 (i.e., definite osteophytes). Knees in which AP laxity decreased had less medial joint space loss than did knees without a decrease in AP laxity. The knee joint may successfully compensate for AP laxity; the absence of such compensation may have a deleterious effect.
Syntheses and Crystal Structures of New Alkali Metal Rare‐Earth Tellurides of the Compositions KLnTe2 (Ln: La, Pr, Nd, Gd), RbLnTe2 (Ln: Ce, Nd) and CsLnTe2 (Ln: Nd).
Authors: Stoewe Klaus , Napoli Christian , Appel Stephan 
Published: July 2005

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Crystal Structure of the Novel Complex Cobalt Oxide Sr0.7Y0.3CoO2.62.
Authors: Istomin S. Ya. , Grins J. , Svensson G. , Drozhzhin O. A. , Kozhevnikov V. L. , Antipov E. V. , Attfield J. P. 
Published: July 2005

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Lewis Acid Catalyzed Benzannulation via Unprecedented [4 + 2] Cycloaddition of o‐Alkynyl(oxo)benzenes and Enynals with Alkynes.
Authors: Asao Naoki , Nogami Tsutomu , Lee Sunyoung , Yamamoto Yoshinori 
Published: July 2005

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Reductive Decomplexation of π‐Allyltricarbonyliron Lactone Complexes Using Sodium Naphthalenide as a Route to Stereodefined 1,7‐Diols and 2,3‐Diene‐1,7‐diols.
Authors: Hollowood Christopher J. , Ley Steven V. 
Published: July 2005

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Synthesis, Physicochemical and Pharmacological Properties of N,N′,N′′,N′′′‐Substituted Amides of 1,1,3,3‐Propanetetracarboxylic Acid.
Authors: Bezuglyi P. A. , Georgiyants V. A. , Perekhoda L. A. , Garnaya N. V. , Sych I. A. 
Published: July 2005

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Carbonyl Allenylations and Propargylations by 3‐Chloro‐1‐propyne or 2‐Propynyl Mesylates with Tin(IV) Chloride and Tetrabutylammonium Iodide.
Authors: Masuyama Yoshiro , Watabe Akiko , Kurusu Yasuhiko 
Published: July 2005

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Reaction of Magnesium Alkylidene Carbenoids with Lithium α‐Sulfonyl Carbanions: A Novel Synthesis of Tri‐ and Tetra‐substituted Allenes from 1‐Chlorovinyl p‐Tolyl Sulfoxides and Sulfones.
Authors: Satoh Tsuyoshi , Sakamoto Tatsuya , Watanabe Masanori , Takano Koji 
Published: July 2005

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Sulfonylimines of Polychloroaldehydes in Reaction with Thioamides.
Authors: Rosentsveig G. N. , Aizina Yu. A. , Rosentsveig I. B. , Levkovskaya G. G. , Sarapulova G. I. , Mirskova A. N. , Drozdova T. I. 
Published: July 2005

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Cascade Transformations of (2,2‐Diaryl‐3,3‐dichloroaziridin‐1‐yl)acetates.
Authors: Khlebnikov A. F. , Novikov M. S. , Kusei E. Yu. , Kopf J. , Kostikov R. R. 
Published: July 2005

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Investigation of the Selective Reduction of Isatin Derivatives. Synthesis of α‐Hydroxyacetophenone Derivatives and Ethyl spiro‐3,3‐(Ethylenedioxy)‐2‐hydroxyindoline Carboxylates.
Authors: Garden Simon J. , Correa Marilza B. , Pinto Angelo C. 
Published: July 2005

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Enantioselective Indole Friedel—Crafts Alkylations Catalyzed by Bis(oxazolinyl)pyridine—Scandium(III) Triflate Complexes.
Authors: Evans David A. , Scheidt Karl A. , Fandrick Keith R. , Lam Hon Wai , Wu Jimmy 
Published: July 2005

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Copper(I)‐Mediated Intramolecular Cyclization of 2‐(2‐Aminophenylethylnyl)benzoic and [2‐(2‐Aminophenylethynyl)phenyl]acetic Acid Esters: A New Synthetic Step Towards Isoindolo[2,1‐a]indoles and 5H‐Indolo[2,1‐a]isoquinolines.
Authors: Reboredo Francisco J. , Treus Monica , Estevez Juan C. , Castedo Luis , Estevez Ramon J. 
Published: July 2005

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Molecular Sieve (MS 4A) Promoted Cyclocondensation of Hindered, Aromatic Nitrile Oxides and Cyclic Diketones under Mild Conditions.
Authors: Matsuura Tomoo , Bode Jeffrey W. , Hachisu Yoshifumi , Suzuki Keisuke 
Published: July 2005

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Reaction of Benzohydroximinoyl Chlorides and β‐(Trifluoromethyl)acetylenic Esters: Synthesis of Regioisomeric (Trifluoromethyl)isoxazolecarboxylate Esters and Oxime Addition Products.
Authors: Hamper Bruce C. , Leschinsky Kindrick L. 
Published: July 2005

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Synthesis and Vasodilating Properties of N‐Alkylamide Derivatives of 4‐Amino‐3‐furoxancarboxylic Acid and Related Azo Derivatives.
Authors: Ovchinnikov I. V. , Kulikov A. S. , Makhova N. N. , Tosco P. , Di Stilo A. , Fruttero R. , Gasco A. 
Published: July 2005

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Stereospecific Synthesis of New 2,3,4,5‐Piperidinetetracarboxylic Acids and 2,3,5‐Piperidinetricarboxylic Acids.
Authors: Arakawa Yasushi , Murakami Tomoaki , Ozawa Fumiko , Arakawa Yukimi , Yoshifuji Shigeyuki 
Published: July 2005

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Synthesis and Antagonistic Activity at Muscarinic Receptor Subtypes of Some Derivatives of Diphenidol
Authors: Varoli Lucilla , Angeli Piero , Buccioni Michela , Burnelli Silvia , Cavalli Andrea , Marucci Gabriella , Recanatini Maurizio 
Published: July 2005

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Cation Radical Imino Diels—Alder Reaction: A New Approach for the Synthesis of Tetrahydroquinolines.
Authors: Jia Xiaodong , Lin Hechun , Huo Congde , Zhang Wei , Lue Jianming , Yang Li , Zhao Guangyu , Liu Zhong‐Li 
Published: July 2005

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Synthesis of N‐Substituted‐N‐acylthioureas of 4‐Substituted Piperazines Endowed with Local Anaesthetic, Antihyperlipidemic, Antiproliferative Activities and Antiarrythmic, Analgesic, Antiaggregating Actions.
Authors: Ranise Angelo , et al. et al. 
Published: July 2005

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Ring Transformations of Heterocyclic Compounds. Part 23. The UV Irradiation Product of Photochromic 2,4,6‐Triaryl‐1‐(spiro[2H‐1‐benzopyran‐2,2′‐indoline]‐6‐yl)pyridinium Salts — A Phenolate Betaine or a Pyridinium Substituted Merocyanine Dye?
Authors: Zimmermann Thomas , Brede Ortwin 
Published: July 2005

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Synthesis of Novel Taxoid Analogue Containing Sulfur Group on C‐13 Side‐Chain: 2′‐Deoxy‐2′‐epi‐mercaptopaclitaxel (I).
Authors: Qi Xin , Lee Sang‐Hyeup , Yoon Juyoung , Lee Yoon‐Sik 
Published: July 2005

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An Enantioselective Approach to Cytotoxic Norcalamenenes via Electron‐Transfer‐Driven Benzylic Umpolung of an Arene Tricarbonyl Chromium Complex.
Authors: Schmalz Hans‐Guenther , Kiehl Oliver , Korell Ursula , Lex Johann 
Published: July 2005

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LNA and α‐L‐LNA: Towards Therapeutic Applications
Authors: Wengel Jesper , Vester Birte , Lundberg Lars Bo , Douthwaite Stephen , Soerensen Mads D. , Babu B. Ravindra , Gait Michael J. , Arzumanov Andrey , Petersen Michael , Nielsen Jakob T. 
Published: July 2005

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2′‐Fluoro‐4′‐thio‐2′,3′‐unsaturated Nucleosides: anti‐HIV Activity, Resistance Profile, and Molecular Modeling Studies
Authors: Chong Youhoon , Choo Hyunah , Schinazi Raymond F. , Chu Chung K. 
Published: July 2005

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Preparation and Properties of a New Type of Acyclic Achiral Nucleoside Analogue
Authors: Boesen Thomas , Sejer Pedersen Daniel , Jensen Jacob , Munck Michael T. , Nielsen Brian M. , Petersen Asger B. , Henriksen Ulla , Dahl Britta M. , Dahl Otto 
Published: July 2005

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Cyclic Uridine Diphosphate Glucose: A New Pyrimidine Analogue of Cyclic ADP Ribose
Authors: Cipolletta Marco , de Champdore Marcella , De Napoli Lorenzo , Di Fabio Giovanni , Messere Anna , Montesarchio Daniela , Piccialli Gennaro 
Published: July 2005

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Furanonaphthoquinones, Atraric Acid and a Benzofuran from the Stem Barks of Newbouldia laevis.
Authors: Gormann Rainer , Kaloga Maki , Li Xing‐Cong , Ferreira Daneel , Bergenthal Dieter , Kolodziej Herbert 
Published: July 2005

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Rigid, Conjugated, Fluoresceinated Thymidine Triphosphates: Syntheses and Polymerase Mediated Incorporation into DNA Analogues.
Authors: Thoresen Lars H. , Jiao Guan‐Sheng , Haaland Wade C. , Metzker Michael L. , Burgess Kevin 
Published: July 2005

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Orientation Disorder in Ammonium Elpasolites — Crystal Structures of (NH4)3AlF6, (NH4)3TiOF5 and (NH4)3FeF6.
Authors: Udovenko A. A. , Laptash N. M. , Maslennikova I. G. 
Published: July 2005

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Structure, Physical Properties, and Charge‐Discharge Characteristics of Fe‐Doped Li2IrO3.
Authors: Kobayashi Hironori , Uebou Yasushi , Tabuchi Mitsuharu , Kageyama Hiroyuki , Yamamoto Yoshifumi , Matsuoka Masao , Tamaki Jun 
Published: July 2005

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A Soluble Block Copolymer‐Supported bis‐Cinchona Alkaloid Ligand for the Asymmetric Dihydroxylation of Olefins.
Authors: Kuang Yong‐Qing , Zhang Sheng‐Yong , Wei Ling‐Ling 
Published: July 2005

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Catalytic Asymmetric Allylation of Aldehydes and Related Reactions with Bis(((S)‐binaphthoxy)(isopropoxy)titanium) Oxide as a μ‐Oxo‐Type Chiral Lewis Acid.
Authors: Hanawa Hideo , Uraguchi Daisuke , Konishi Shunsuke , Hashimoto Takuya , Maruoka Keiji 
Published: July 2005

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A Novel Palladium‐Catalyzed Coupling of Epoxides with Allyl Bromide Mediated by Indium(I) Chloride: A Cascade Epoxide Rearrangement—Carbonyl Allylation.
Authors: Jiang Nan , Hu Qingyuan , Reid Carrolyn S. , Lu Yunfeng , Li Chao‐Jun 
Published: July 2005

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Triethylborane as an Efficient Promoter for Palladium‐Catalyzed Allylation of Active Methylene Compounds with Allyl Alcohols.
Authors: Kimura Masanari , Mukai Ryutaro , Tanigawa Naoko , Tanaka Shuji , Tamaru Yoshinao 
Published: July 2005

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The One‐Pot Synthesis and Diels—Alder Reactivity of 2,5‐Dihydrothiophene‐1,1‐dioxide‐3‐carboxylic Acid.
Authors: Andrade Genara S. , Berkner Joachim E. , Liotta Charles L. , Eckert Charles , Schiraldi David A. , Andersen Arthur , Collard David M. 
Published: July 2005

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Complete Memory of Chirality Upon Photodecarboxylation of Mesityl Alkanoate to Mesitylalkane: Theoretical and Experimental Evidence for Cheletropic Decarboxylation via a Spiro‐Lactonic Transition State.
Authors: Mori Tadashi , Saito Hideaki , Inoue Yoshihisa 
Published: July 2005

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Substitution of the Benzotriazolyl Group in N‐(α‐Amidoalkyl)benzotriazoles and N‐(α‐Sulfonamidoalkyl)benzotriazoles with Allylsamarium Bromide.
Authors: Wang Xiaoxia , Li Jian , Zhang Yongmin 
Published: July 2005

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Anilines Made Easily: From Aldehydes to Tri‐, Tetra‐, and Pentasubstituted Anilines in Two Steps.
Authors: Neumann Helfried , Jacobi von Wangelin Axel , Klaus Stefan , Struebing Dirk , Goerdes Dirk , Beller Matthias 
Published: July 2005

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Sequential Wittig Olefination—Catalytic Asymmetric Epoxidation with Reuse of Waste Ph3P(O): Application of α,β‐Unsaturated N‐Acyl Pyrroles as Ester Surrogates.
Authors: Kinoshita Tomofumi , Okada Shigemitsu , Park Sun‐Ryung , Matsunaga Shigeki , Shibasaki Masakatsu 
Published: July 2005

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New Way of the Reaction of 1‐Amino‐6,7‐difluoro‐4‐oxoquinolyl‐3‐ethylcarboxylate with Acetoacetone.
Authors: Azev Yuri A. , Lork Enno , Gabel Detlef , Duelcks Thomas 
Published: July 2005

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4‐Substituted 1,5‐Diarylpyrazole, Analogues of Celecoxib: Synthesis and Preliminary Evaluation of Biological Properties.
Authors: Menozzi Giulia , Merello Luisa , Fossa Paolo , Mosti Luisa , Piana Antonietta , Mattioli Francesca 
Published: July 2005

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Samarium Diiodide Mediated Barbier‐Type Reaction of 2‐Chloromethylbenzoxazole and 2‐Chloromethylbenzothiazole with Carbonyl Compounds: A Convenient Synthesis of 1‐(β‐Hydroxyalkyl)benzoxazoles and 1‐(β‐Hydroxyalkyl)benzothiazoles.
Authors: Xu Xiaoliang , Zhang Yongmin 
Published: July 2005

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Thermal Rearrangements of 3‐Substituted 4‐(3‐Ethoxycarbonylthioureido)‐1,2,5‐oxadiazole 2‐Oxides.
Authors: Molotov Sergey I. , Kulikov Alexander S. , Makhova Nina N. , Lyssenko Konstantin A. 
Published: July 2005

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