bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bleomycin induced EBV-specific gastric epithelial cell death is enhanced by LMP2A
Authors: Wai Aung Phyo , Azzahra Ahmad Wadi Afifa Fatimah , Liu Yuxin , Zolzaya Tumurgan , Okada Shunpei , Iizasa Hisashi , Yoshiyama Hironori 
Published: January 2024

ABSTRACTEpstein-Barr virus (EBV) infects more than 90% of the global population, leading to EBV-related cancers, such as EBV-associated gastric cancer and nasopharyngeal carcinoma. Despite the rarity of p53 mutations in tumor cells, there is a lack of specific therapies targeting EBV-associated gastric cancers. Our study demonstrated that EBV-infected gastric epithelial cells exhibited high sensitivity to the bleomycin family, encompassing bleomycin and zeocin, compared to uninfected cells. Zeocin treatment induces a DNA damage response (DDR) and promotes the expression of BZLF1, triggering the expression of EBV lytic genes. This cascade leads to apoptosis via a p53 dependent pathway, coinciding with the activation of caspase-3. Cells infected with the BZLF1-deficient virus could not induce apoptosis by zeocin treatment, and the cells maintained a tight latent infection but initiated a robust DDR. Conversely, neither lytic infection nor DDR was induced by zeocin treatment in cells infected with LMP2A-deficient virus. These findings indicate that LMP2A augments DDR in EBV-infected gastric epithelial cells, facilitating the transition from latent to lytic infection, and consequently inducing cell death. Bleomycin derivatives are expected to serve as fundamental components in the development of specific anticancer drugs targeting EBV-positive epithelial cancer cells.IMPORTANCEBecause of its ubiquitous infection in the human population, the number of patients suffering from EBV-related diseases, including malignant tumors and severe active infections, is substantial. Previous research has reported the potential of drugs such as HDAC inhibitors and poly ADP-ribose polymerase inhibitors to induce cell death in EBV-infected cells. However, a clinical therapeutic agent specifically reducing EBV-infected cells has not yet been available. In this study, we report that bleomycin, or its derivative, which has been used for over half a century, induces apoptotic cell death in EBV-infected cells by triggering lytic viral replication associated with DNA damage response. Particularly, we discovered that the viral latent gene LMP2A unexpectedly enhances bleomycin-induced EBV-infected epithelial cell death by promoting DDR.
How employee mindfulness influences the retention intention of technology employees: multiple mediation effects of affective commitment and organizational identification
Authors: Liu Jianxi , Gan Yu , Chen YiJun 
Published: January 2024

PurposeThis study delves into the impact of mindfulness on the retention intention of technology employees, with a particular focus on the mediating variables of affective commitment (AC) and organizational identification (OI). The primary aim is to gain a comprehensive understanding of the underlying mechanisms through which mindfulness influences the retention intention of technology employees.Design/methodology/approachThe research employed a survey approach with self-administered questionnaires and structural equation modeling. The collected data were analyzed using Statistical Product and Service Solutions (SPSS) 24 and Analysis of Moment Structure (AMOS) 28. Multiple mediation analyses was conducted through AMOS to examine the mediating effects of OI and AC.FindingsThe association between mindfulness and retention intention among technology employees showed an overall positive correlation. Additionally, AC and OI were positively correlated with retention intention. In the impact of employee mindfulness (EM) on retention intention, all indirect effects were found to be significant.Originality/valueTo the best of the authors' knowledge, this study is the first to investigate the relationship between EM and retention intention, as well as the associations of AC and OI with them, extending the application of mindfulness in management and offering insights for talent retention among company decision-makers.
Difficulties experienced by Latin American oil and gas companies in the integrated adoption of practices aligned with the UN SDGs
Authors: Borges Fabíola M.M.G. , Anholon Rosley , Rampasso Izabela Simon , Sigahi Tiago F.A.C. , Moraes Gustavo Hermínio Salati Marcondes de , Leal Filho Walter 
Published: January 2024

Purpose
This paper aims to understand the difficulties faced by Latin American oil and gas (O&G) companies in adopting integrated practices aligned with the UN Sustainable Development Goals (SDG) Agenda.

Design/methodology/approach
A Delphi study was conducted with 14 experts with extensive knowledge and experience in the O&G sector to collect opinions and investigate sustainable practices in the Latin American context.

Findings
A consensus was reached after two rounds, demonstrating a unified view of sustainability experts on the difficulties faced by O&G companies to adopt practices aligned with the SDGs. The difficulties identified through the Delphi method were allocated into five clusters named: “public sector and governments,” “civil society,” “corporate issues,” “technology and innovation” and “financial aspects.” These clusters were used to discuss the main challenges associated with implementing business practices that recognize the SDGs and their achievement as a synergistic reinforcing system rather than an additive structure.

Originality/value
This study provides further insights into the underexplored subject relating to the challenges experienced by Latin American O&G companies in the implementation of the SDGs, adopting the perspective of academic and industry experts in this field. The findings can help professionals in O&G companies implement sustainable practices, policymakers in debates about futures laws and regulations and academic in future research.
Gender-specific occupational stress management in construction professionals: a comparative analysis of contractor quantity surveyors work at site
Authors: Gunasekara K.A. , Perera B.A.K.S. , Kurukulasooriya I.N. 
Published: January 2024

Purpose
The construction industry is one of the most stressful industries. Thus, quantity surveyors (QSs) who work at sites frequently experience high levels of occupational stress. The gender of a QS also has a significant impact on his/her occupational stress. Hence, this study aims to investigate the management of occupational stress in QSs working at sites for contractors (hereinafter referred to as CQSs).

Design/methodology/approach
The study adopted a mixed approach using semi-structured interviews and a questionnaire survey for female and male CQSs to identify, validate and rank the stressors and symptoms of occupational stress in CQSs and the strategies of managing that stress based on their significance levels. Manual content analysis and the mean weighted rating were used to analyse the data collected.

Findings
Heavy workload was the most significant occupational stressor of CQSs, whereas sleeping disorders were their primary symptom of occupational stress. Establishing a proper work programme was identified as the most effective stress management strategy for male and female CQSs. This study shows that many site QSs are stressed owing to their heavy workloads and work obligations and that their stress-related attributes significantly depend on their genders.

Originality/value
This study is significant because no previous studies have been conducted on managing occupational stress in CQSs in male and female CQSs. The study findings can be used to identify the stressors and symptoms of occupational stress in CQSs early and use appropriate management strategies to enhance the work satisfaction and productivity of CQSs suffering from occupational stress.
Automation of text document classification in the budgeting phase of the Construction process: a Systematic Literature Review
Authors: Jacques de Sousa Luís , Poças Martins João , Sanhudo Luís , Santos Baptista João 
Published: January 2024

Purpose
This study aims to review recent advances towards the implementation of ANN and NLP applications during the budgeting phase of the construction process. During this phase, construction companies must assess the scope of each task and map the client’s expectations to an internal database of tasks, resources and costs. Quantity surveyors carry out this assessment manually with little to no computer aid, within very austere time constraints, even though these results determine the company’s bid quality and are contractually binding.

Design/methodology/approach
This paper seeks to compile applications of machine learning (ML) and natural language processing in the architectural engineering and construction sector to find which methodologies can assist this assessment. The paper carries out a systematic literature review, following the preferred reporting items for systematic reviews and meta-analyses guidelines, to survey the main scientific contributions within the topic of text classification (TC) for budgeting in construction.

Findings
This work concludes that it is necessary to develop data sets that represent the variety of tasks in construction, achieve higher accuracy algorithms, widen the scope of their application and reduce the need for expert validation of the results. Although full automation is not within reach in the short term, TC algorithms can provide helpful support tools.

Originality/value
Given the increasing interest in ML for construction and recent developments, the findings disclosed in this paper contribute to the body of knowledge, provide a more automated perspective on budgeting in construction and break ground for further implementation of text-based ML in budgeting for construction.
A study of social visibility and engagement of world-renowned libraries on Twitter
Authors: Wani Zahid Ashraf , Ahmad Majid 
Published: January 2024

Purpose
The purpose of this study is to investigate how libraries use Twitter as a social media platform and examine the tweets they post, including multimedia content such as images and video clips. The study also aims to analyse the relationship between post types and user engagement and evaluate the effects of post features, such as multimedia content, on user engagement.

Design/methodology/approach
The methodology of the study involved three phases. In Phase 1, a review of related literature was conducted to develop a holistic approach for the study. In Phase 2, official Twitter handles of selected libraries were identified and verified for authenticity using various methods, including cross-checking with library websites. During Phase 3, data was collected from the Twitter handles. The data was then tabulated and interpreted to achieve the set objectives of the study.

Findings
The paper examined the tweets posted by select libraries on Twitter and their impact on user engagement. The study found that most tweets were related to library resources/collection and announcements, followed by events hosted by libraries. Emotionally inspiring posts and daily facts were also commonly posted. The findings also showed that including images in tweets resulted in higher levels of user engagement than video clips did. The study suggests that incorporating images fosters engagement and boosts retweets, while watching a video takes more effort and time.

Practical implications
The practical implications of the study can provide insights into the tweets that generate user engagement, which can help libraries tailor their social media strategies to attract and retain more followers. The paper can help libraries measure the success of their social media activities by evaluating user engagement metrics.

Originality/value
The originality/ value of the study lies in its examination of how libraries use Twitter as a social media platform, including the tweets they post and the impact of multimedia content on user engagement. While previous studies have examined the use of social media by libraries, this study focuses specifically on Twitter and provides a detailed analysis of the tweets that generate user engagement.
ICT training, digital transformation and company performance: an empirical study
Authors: Nicolás-Agustín Álvaro , Jiménez-Jiménez Daniel , Maeso Fernandez Francisco , Di Prima Christian 
Published: January 2024

PurposeThis study presents a model for assessing the effects of employee ICT training on organizations’ results. It also introduces digital transformation as a mediator between the two concepts and studies the role of organizational commitment and human capital in terms of digital transformation.Design/methodology/approachSurveys were completed by the CEOs of 184 Spanish companies, and their responses were analyzed with Partial Least Squares.FindingsThe results empirically analyze the proposed theoretical model and highlight the fact that human capital and organizational commitment partially mediate the link between ICT training and digital transformation. Furthermore, there is a direct relationship between ICT training and company performance.Practical implicationsDirectors and managers should invest more resources in the human capital of their company through ICT training. In fact, it can improve organizational commitment, encouraging employees to adopt innovative behaviors, thus allowing for the necessary digital transformation.Originality/valueDespite heavy theoretical emphasis on the study of the conditions necessary for the digital transformation of companies, few studies have empirically analyzed the effects of adopting certain practices for its implementation. This paper focuses on analyzing the effect of ICT training, which is configured as a tool capable of improving staff knowledge and increasing employee commitment. This is essential for adopting organizational change such as digital transformation.
Usability testing of mobile learning applications: a systematic mapping study
Authors: Kumar Bimal Aklesh , Chand Sailesh Saras , Goundar Munil Shiva 
Published: January 2024

PurposeMobile learning has seen tremendous growth over the years. Like any other software application, usability is one of the key concerns in its successful implementation. There is a lack of study that provides a comprehensive overview of usability testing of mobile learning applications. Motivated by this a mapping study is conducted.Design/methodology/approachA systematic mapping study was conducted using 51 papers retrieved from the Scopus database published between 2005 and 2022 that reported on usability testing of mobile learning applications.FindingsThe key findings suggest that research is expected to expand in the near future. User-based testing is the commonly used method, while data are collected mainly through questionnaires, observation and interviews. Testing is mainly conducted in a controlled environment.Originality/valueThe study provides (1) an evidence-based discussion on usability testing of mobile learning applications, (2) an up-to-date map on state of the art on usability testing of mobile learning applications and (3) providing direction for further research to scientifically strengthen the field.
Institutional theory and multinational corporation internationalization strategy: a systematic review and future research agenda
Authors: Saikia Anuradha , Bhattacharya Sharad Nath , Dwivedi Rohit 
Published: January 2024

PurposeThis study reviews the literature on institutional theory in international business and examines the institutional factors behind the success or failure of multinational corporations (MNCs) in emerging markets.Design/methodology/approachThis systematic literature review analysed 116 peer-reviewed articles published in leading journals between 2005 and 2022. The R package Bibliometrix and VOSviewer visualization software were used for analysis. A hybrid methodology combining bibliometric and content analyses was utilized to obtain a descriptive evaluation of the publication impact along with a keyword co-occurrence map, context-specific institutional effects and subsidiary strategies.FindingsThe Journal of International Business Studies, along with influential authors such as Mike W. Peng, Klaus Meyer, and Mehmet Demirbag, have taken the lead in advancing institutional theories for MNC internationalization in emerging markets. The clusters from the co-word analysis revealed dominant MNC entry modes, institutional distances and MNC localization strategies. The content analysis highlights how the institutional environment is operationalized across the macro-, micro- and meso-institutional contexts and how the MNC subsidiary responds in emerging markets. Meso-level interactions emphasize the relational aspects of business strategies in emerging markets.Practical implicationsContextualizing subsidiary strategies and institutional forms can help managers align their strategic responses to the dynamic relationship between subsidiaries and the institutional environment. The review findings will enable policymakers to simplify regulatory policies and encourage MNC subsidiary networks with local stakeholders in emerging markets.Social implicationsLegitimacy strategies such as corporate community involvement in emerging markets are crucial for enhancing societal support and removing stakeholders' scepticism for MNC business operations in emerging markets. Moral legitimacy should be implemented by managers, such as lending support to disaster management efforts and humanitarian crises, as they expand to new business environments of emerging markets.Originality/valueThis study is the first to explore institutional diversity and subsidiary strategic responses in a three-layered institutional context. The findings highlight the relevance of contextualizing institutional perspectives for international business scholars and practitioners as they help build context-specific theoretical frameworks and business strategies. Future research recommendations are suggested in the macro-, micro- and meso-institutional contexts.
Investigation of TiO2 replacement alternatives for water-based paints using styrene butyl acrylate
Authors: Aygül Seda , Yılmazsönmez Serkan , Soyalp Arzu , Aytac Ayse 
Published: January 2024

Purpose
Titanium dioxide (TiO2) has high opacity, high brightness and whiteness, owing to its high refractive index value. It is mainly used in the coating industry and continuous efforts have been made to replace some of the TiO2 in paint with new pigments. This study aims to replace part of TiO2 pigment with various percentages of BaSO4, CaCO3 and kaolin in styrene butyl acrylate-based paint formulations, without changing the properties of paints using only titanium dioxide.

Design/methodology/approach
To determine the optimum use rate of new pigment mixing, opacity, gloss, scrub resistance and weather resistance properties have been investigated in the water-based paint formulation. The morphological properties of these samples were examined by scanning electron microscopy analysis.

Findings
In the total color change (ΔE) measurements, it was observed that the sample coded 85Ti/15Ba produced extremely similar results to the situation when TiO2 was used alone. It was seen that the best results were obtained when 85Ti/15Ba was used instead of TiO2.

Originality/value
Comparison research on the impact of replacing TiO2 with BaSO4, CaCO3 and kaolin on the performance characteristics of water-based styrene butyl acrylate-based paint formulations has not been done in the literature, according to the literature search.
Human-robot collaborative task planning for assembly system productivity enhancement
Authors: Inkulu Anil Kumar , Bahubalendruni M.V.A. Raju 
Published: January 2024

Purpose
In the current era of Industry 4.0, the manufacturing industries are striving toward mass production with mass customization by considering human–robot collaboration. This study aims to propose the reconfiguration of assembly systems by incorporating multiple humans with robots using a human–robot task allocation (HRTA) to enhance productivity.

Design/methodology/approach
A human–robot task scheduling approach has been developed by considering task suitability, resource availability and resource selection through multicriteria optimization using the Linear Regression with Optimal Point and Minimum Distance Calculation algorithm. Using line-balancing techniques, the approach estimates the optimum number of resources required for assembly tasks operating by minimum idle time.

Findings
The task allocation schedule for a case study involving a punching press was solved using human–robot collaboration, and the approach incorporated the optimum number of appropriate resources to handle different types of proportion of resources.

Originality/value
This proposed work integrates the task allocation by human–robot collaboration and decrease the idle time of resource by integrating optimum number of resources.
What is the impact of seasonal ambient changes on the incidence of falls among older adults?
Authors: Byrne Richard , Patton Declan , Moore Zena , O’Connor Tom , Nugent Linda , Avsar Pinar 
Published: January 2024

Purpose
This systematic review paper aims to investigate seasonal ambient change’s impact on the incidence of falls among older adults.

Design/methodology/approach
The population, exposure, outcome (PEO) structured framework was used to frame the research question prior to using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis framework. Three databases were searched, and a total of 12 studies were found for inclusion, and quality appraisal was carried out. Data extraction was performed, and narrative analysis was carried out.

Findings
Of the 12 studies, 2 found no link between seasonality and fall incidence. One study found fall rates increased during warmer months, and 9 of the 12 studies found that winter months and their associated seasonal changes led to an increase in the incidence in falls. The overall result was that cooler temperatures typically seen during winter months carried an increased risk of falling for older adults.

Originality/value
Additional research is needed, most likely examining the climate one lives in. However, the findings are relevant and can be used to inform health-care providers and older adults of the increased risk of falling during the winter.
Phylogeny and climate explain contrasting hydraulic traits in different life forms of 150 woody Fabaceae species
Authors: Liu Hui , Ye Qing , Lundgren Marjorie R. , Young Sophie N. R. , Liu Xiaorong , Luo Qi , Lin Yixue , Ye Nan , Hao Guangyou 
Published: January 2024

Abstract

The contrasting hydraulic traits observed among different plant life forms are shaped by entangled environmental and evolutionary processes. However, we lack understanding of the relative importance of life form, climate and phylogeny in explaining the variance of hydraulic traits.

We analysed seven hydraulic traits and eleven climatic variables of 150 Fabaceae species representing three life forms from 62 sites worldwide, using phylogenetic comparative analyses and variance partitioning.

The phylogenetic signal found in most traits disappeared after considering life form, indicating that phylogenetic conservatism in traits originated from the divergence among life forms. The trait‐climate relationships were also phylogenetically dependent, implying that trait responses are driven by climate and phylogeny together. Variance partitioning showed that phylogeny and climate explained greater trait variation than life form did.

Synthesis. The climate‐driven hydraulic trait responses in Fabaceae still existed with phylogeny being considered, suggesting that this large family may be particularly sensitive to climate change. Our results emphasise the need to include phylogeny in plant hydraulic adaptation studies under future climate change.