bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and prognostic factors of bacterial meningitis in the intensive care unit: a prospective nationwide cohort study
Authors: Chekrouni Nora , Kroon Merel , Drost Evelien H. G. M. , van Soest Thijs M. , Bijlsma Merijn. W. , Brouwer Matthijs C. , van de Beek Diederik 
Published: December 2023

Abstract
Background
Patients with bacterial meningitis can be severely ill necessitating intensive care unit (ICU) treatment. Here, we describe clinical features and prognostic factors of adults with bacterial meningitis admitted to the ICU in a nationwide prospective cohort study.

Methods
We prospectively assessed clinical features and outcome of adults (age > 16 years) with community-acquired bacterial meningitis included in the MeninGene study between March 1, 2006 and July 1, 2022, that were initially admitted to the ICU. We identified independent predictors for initial ICU admission and for unfavourable outcome (Glasgow Outcome Scale score between 1–4) by multivariable logistic regression.

Results
A total of 2709 episodes of bacterial meningitis were included, of which 1369 (51%) were initially admitted to the ICU. We observed a decrease in proportion of patients being admitted to the ICU during the Covid-19 pandemic in 2020 (decreased to 39%, p = 0.004). Median age of the 1369 patients initially admitted to the ICU was 61 years (IQR 49–69), and the rates of unfavourable outcome (47%) and mortality (22%) were high. During the Covid-19 pandemic, we observed a trend towards an increase in unfavourable outcome. Prognostic factors predictive for initial ICU admission were younger age, immunocompromised state, male sex, factors associated with pneumococcal meningitis, and those indicative of systemic compromise. Independent predictors for unfavourable outcome in the initial ICU cohort were advanced age, admittance to an academic hospital, cranial nerve palsies or seizures on admission, low leukocyte count in blood, high C-reactive protein in blood, low CSF: blood glucose ratio, listerial meningitis, need for mechanical ventilation, circulatory shock and persistent fever. 204 of 1340 episodes (15%) that were initially not admitted to the ICU were secondarily transferred to the ICU. The rates of unfavourable outcome (66%) and mortality (30%) in this group were high.

Conclusions
The majority of patients with community-acquired bacterial meningitis are admitted to the ICU, and the unfavourable outcome and mortality rates of these patients remain high. Patients that are initially admitted to non-ICU wards but secondarily transferred to the ICU also had very high rates of unfavourable outcome.
Severe infections requiring intensive care unit admission in patients receiving ibrutinib for hematological malignancies: a groupe de recherche respiratoire en réanimation onco-hématologique (GRRR-OH) study
Authors: Baucher Louise , Lemiale Virginie , Joseph Adrien , Wallet Florent , Pineton de Chambrun Marc , Ferré Alexis , Lombardi Romain , Platon Laura , Contejean Adrien , Fuseau Charline , Calvet Laure , Pène Frédéric , Kouatchet Achille , Mokart Djamel , Azoulay Elie , Lafarge Antoine 
Published: December 2023

Abstract
Background
In the last decade, Ibrutinib has become the standard of care in the treatment of several lymphoproliferative diseases such as chronic lymphocytic leukemia (CLL) and several non-Hodgkin lymphoma. Beyond Bruton tyrosine kinase inhibition, Ibrutinib shows broad immunomodulatory effects that may promote the occurrence of infectious complications, including opportunistic infections. The infectious burden has been shown to vary by disease status, neutropenia, and prior therapy but data focusing on severe infections requiring intensive care unit (ICU) admission remain scarce. We sought to investigate features and outcomes of severe infections in a multicenter cohort of 69 patients receiving ibrutinib admitted to 10 French intensive care units (ICU) from 1 January 2015 to 31 December 2020.

Results
Median time from ibrutinib initiation was 6.6 [3–18] months. Invasive fungal infections (IFI) accounted for 19% (n = 13/69) of severe infections, including 9 (69%; n = 9/13) invasive aspergillosis, 3 (23%; n = 3/13) Pneumocystis pneumonia, and 1 (8%; n = 1/13) cryptococcosis. Most common organ injury was acute respiratory failure (ARF) (71%; n = 49/69) and 41% (n = 28/69) of patients required mechanical ventilation. Twenty (29%; n = 20/69) patients died in the ICU while day-90 mortality reached 55% (n = 35/64). In comparison with survivors, decedents displayed more severe organ dysfunctions (SOFA 7 [5–11] vs. 4 [3–7], p = 0.004) and were more likely to undergo mechanical ventilation (68% vs. 31%, p = 0.010). Sixty-three ibrutinib-treated patients were matched based on age and underlying malignancy with 63 controls receiving conventional chemotherapy from an historic cohort. Despite a higher median number of prior chemotherapy lines (2 [1–2] vs. 0 [0–2]; p < 0.001) and higher rates of fungal [21% vs. 8%, p = 0.001] and viral [17% vs. 5%, p = 0.027] infections in patients receiving ibrutinib, ICU (27% vs. 38%, p = 0.254) and day-90 mortality (52% vs. 48%, p = 0.785) were similar between the two groups.

Conclusion
In ibrutinib-treated patients, severe infections requiring ICU admission were associated with a dismal prognosis, mostly impacted by initial organ failures. Opportunistic agents should be systematically screened by ICU clinicians in this immunocompromised population.
Does climate change alter the nutrient trends of Cedrela fissilis Vell. trees in the southern Brazilian Amazon?
Authors: Ortega Rodriguez Daigard R. , Sánchez-Salguero Raúl , Hevia Andrea , Bovi Renata C. , Ferreira Marciel J. , Speer James H. , Roig Fidel A. , Tomazello-Filho Mario 
Published: December 2023

Abstract
Background
The increase in the frequency and intensity of droughts is pointed out as one of the main factors altering biogeochemical cycles in the Amazon basin. An eco-nutritional approach using X-ray fluorescence micro-analysis (µXRF) is proposed to verify the long- and short-term effects of droughts on the growth and xylem nutrient concentrations of Cedrela fissilis Vell.

Methods
Fourteen radii were selected from a tree-ring width chronology and X-rayed by Itrax Multiscanner. Profiles of ring width, wood density, and concentrations of aluminum (Al), phosphorus (P), sulfur (S), calcium (Ca), potassium (K), manganese (Mn), iron (Fe) and strontium (Sr) together with Al/Ca, Ca/Mn, K/Ca, Sr/Ca and Mn/S ratios were constructed and correlated with precipitation, temperature, the difference between precipitation and potential evapotranspiration (P-PET) and standardized precipitation–evapotranspiration index (SPEI).

Results
During dry years, C. fissilis showed narrower, less dense rings, lower Al, P, S and Ca, and higher K and Fe concentrations (the opposite was found in wet years). Ring width decreased (together with Al, P, S, K, Ca, Mn, Fe, Sr, Al/Ca, K/Ca and Sr/Ca) and wood density increased (together with Ca/Mn and Mn/S), which was associated with an increase in evapotranspiration and temperature over time, mainly since 1990. Cedrela fissilis showed a tendency to increase its capacity for resistance, and a recovery and resilience in growth over time associated with responses in Al, Ca, P and S. However, it showed a risk in the capacity for recovery of the pre-drought density values, associated with unsatisfactory responses in Al, Ca, K, Fe and P.

Conclusions
This study is the first attempt to analyze tree-ring nutritional evidences of C. fissilis trees to climate sensitivity and resilience to drought, based on long-term data from seasonal moist tropical forests of the Amazon. Our data suggested that C. fissilis is undergoing alterations in the concentration, use and redistribution of nutrients associated with increasing wood density and decreasing growth over time, due to the increase of drought frequency in the southern Amazon.
Gamified antimicrobial decision support app (GADSA) changes antibiotics prescription behaviour in surgeons in Nigeria: a hospital-based pilot study
Authors: Luedtke Susanne , Wood Caroline , Olufemi Olajumoke , Okonji Patrick , Kpokiri Eneyi E. , Musah Anwar , Bammeke Funmi , Mutiu Bamidele , Ojewola Rufus , Bankole Olufemi , Ademuyiwa Adesoji , Ekumankama Chibuzo , Theophilus Ayibanoah , Aworabhi-Oki Neni , Shallcross Laura , Molnar Andreea , Wiseman Sue , Hayward Andrew , Birjovanu Georgiana , Lefevre Carmen , Petrou Stylianos , Ogunsola Folasade , Kostkova Patty 
Published: December 2023

Abstract
Aims
Surgical Antibiotic Prophylaxis (SAP) in Nigeria is often not evidence based. The aim of this study is to test if the GADSA application can change prescription behaviour of surgeons in Nigeria. In addition, the study aims to identify AMS strategies and policies for the future.

Methods
The GADSA gamified decision support app uses WHO and Sanford prescribing guidelines to deliver real-time persuasive technology feedback to surgeons through an interactive mentor. The app can advise on whether clinician’s decisions align with SAP recommendations and provides the opportunity for clinicians to make adjustments. Twenty surgeons actively participated in a 6-month pilot study in three hospitals in Nigeria. The surgeons determined the risk of infection of a surgical procedure, and the need, type and duration of SAP. The study used a longitudinal approach to test whether the GADSA app significantly changed prescribing behaviour of participating surgeons by analysing the reported prescription decisions within the app.

Results
321 SAP prescriptions were recorded. Concerning the surgical risk decision, 12% of surgeons changed their decision to be in line with guidelines after app feedback (p < 0.001) and 10% of surgeons changed their decision about the need for SAP (p = 0.0035) to align with guidelines. The change in decision making for SAP use in terms of “type” and “duration” to align with guidelines was similar with 6% and 5% respectively (both p-values < 0.001).

Conclusion
This study suggests that the GADSA app, with its game based and feedback feature, could significantly change prescribing behaviour at the point of care in an African setting, which could help tackle the global challenge of antibiotic resistance.
The evaluation of hand-crafted and learned-based features in Terrestrial Laser Scanning-Structure-from-Motion (TLS-SfM) indoor point cloud registration: the case study of cultural heritage objects and public interiors
Authors: Markiewicz Jakub , Kot Patryk , Markiewicz Łukasz , Muradov Magomed 
Published: December 2023

Abstract
Modern technologies are commonly used to inventory different architectural or industrial objects (especially cultural heritage objects and sites) to generate architectural documentation or 3D models. The Terrestrial Laser Scanning (TLS) method is one of the standard technologies researchers investigate for accurate data acquisition and processing required for architectural documentation. The processing of TLS data to generate high-resolution architectural documentation is a multi-stage process that begins with point cloud registration. In this step, it is a common practice to identify corresponding points manually, semi-manually or automatically. There are several challenges for the TLS point cloud processing in the data registration process: correct spatial distribution, marking of control points, automation, and robustness analysis. This is particularly important when large, complex heritage sites are investigated, where it is impossible to distribute marked control points. On the other hand, when orientating multi-temporal data, there is also the problem of corresponding reference points. For this reason, it is necessary to use automatic tie-point detection methods. Therefore, this article aims to evaluate the quality and completeness of the TLS registration process using 2D raster data in the form of spherical images and Affine Hand-crafted and Learned-based detectors in the multi-stage TLS point cloud registration as test data; point clouds were used for the historic 17th-century cellars of the Royal Castle in Warsaw without decorative structures, two baroque rooms in the King John III Palace Museum in Wilanów with decorative elements, ornaments and materials on the walls and flat frescoes, and two modern test fields, narrow office, and empty shopping mall. The extended Structure-from-Motion was used to determine the tie points for the complete TLS registration and reliability analysis. The evaluation of detectors demonstrates that for the test sites exhibiting rich textures and numerous ornaments, a combination of AFAST, ASURF, ASIFT, SuperGlue and LoFTR can be effectively employed. For the point cloud registration of less textured buildings, it is advisable to use AFAST/ASIFT. The robust method for point cloud registration exhibits comparable outcomes to the conventional target-based and Iterative Closest Points methods.
Quantitative analysis of 3D seam shape according to easing conditions for efficient sewing using muslin
Authors: Lee Hyojeong , Park Sunhee , Lee Yejin 
Published: December 2023

AbstractThis study quantitatively analyzes the data of 3D seam shapes that alter according to easing conditions. By numerically approaching easing, which is only taught using traditional methods, this study suggests a method of analyzing the changes in 3D surface area, volume, and seam shape. The 3D data of the completed samples were obtained through a 3D scanner, the solid shapes were analyzed using reverse engineering, and a new program was developed. The shape, area, and volume of the data were analyzed, and the deformation rate was measured using the radius of curvature. Linear seam lines were bent because of the mechanical pushing inflicted by the garment with easing. The area increased dramatically as the ease amount increased when the seam lines were short, whereas it was relatively unaffected when seam lines were long. The radii of curvature for curved seam lines show that, for all samples, the waveform is high at the center where the seam is. The peak value did not increase for curved seams when the ease amount increased. The sum of the areas increased with a larger radius of curvature for the curved seams. It is a crucial reference for easing in garments regarding quantitative changes in seam shapes and volumes according to easing type and amount.
Chairside 3-D printed impression trays: a new approach to increase the accuracy of conventional implant impression taking? An in vitro study
Authors: Schmidt Alexander , Berschin Cara , Wöstmann Bernd , Schlenz Maximiliane Amelie 
Published: December 2023

Abstract
Purpose
A high transfer accuracy of the intraoral implant position to a model is required, to manufacture implant-supported restorations. However, clinically relevant deviations persist between the intraoral implant position and the model obtained, even for the benchmark conventional custom implant impressions with polyether. Thus, new approaches using 3-D printed impression trays may increase the transfer accuracy of implant impressions. The ability to adjust parameters such as the thickness of the layers and the influence of the openings in the impression tray could potentially affect accuracy.

Methods
Four different types of impression trays (n = 10 for each group) for the conventional impression technique were investigated: conventional custom impression tray, customized foil tray, chairside 3-D printed impression tray with the SHERA system, and the Primeprint system using an implant master model with four implants in the posterior region and a reference cube. After plaster model casting, all models were measured using a coordinate measuring machine, and the deviation from the reference dataset was determined. A statistical ANOVA analysis was performed (p < 0.05).

Results
Chairside 3-D printed impression trays showed the best results, followed by conventional custom impression trays. Implant impressions obtained using a customized foil tray exhibited the lowest accuracy. Statistically significant differences were observed between 3-D printed impression trays and conventional custom impression and customized foil trays (p < 0.05). Whereas, the implant position did not have any significant influence on accuracy (p > 0.05).

Conclusions
Chairside 3-D printed impression trays significantly increase the transfer accuracy for implant impression taking.

Graphical Abstract
Fat mass and obesity-associated gene (FTO) rs9939609 (A/T) polymorphism and food preference in obese people with low-calorie intake and non-obese individuals with high-calorie intake
Authors: Rahimlou Mehran , Ghobadian Bijan , Ramezani Ali , Hejazi Ehsan , Mazloomzadeh Saeideh , Hejazi Jalal 
Published: December 2023

AbstractThe purpose of this study was to assess the connection between FTO rs9939609 (A/T) polymorphism and food preference. The study included 77 participants, 36 of whom were obese and had a low-calorie intake, and 41 non-obese participants with a high-calorie intake. Using a food frequency questionnaire (FFQ), the researchers calculated sweet and fatty food propensity scores. Genomic DNA was extracted from a peripheral blood sample from all participants, and FTO rs9939609 (A/T) polymorphism was assessed using standard methods. The study found no significant differences between the two groups in terms of sweet food preference (15.64 ± 10.53 in obese groups vs. 14.72 ± 7.95 in the non-obese group, p = 0.711) and fatty food preference (16.81 ± 8.84 vs. 17.27 ± 8.75; p = 0.833). Additionally, the study did not find any significant correlation between FTO rs9939609 (A/T) polymorphism and sweet and fatty food preferences in the fully adjusted models (p > 0.05). Therefore, the results of this study do not support the hypothesis of different food preferences.
Aortic valve replacement in a 41-year-old woman with uncorrected tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries: a case report
Authors: Saito Kazutomo , Iwasaki Yudai , Tasaki Takahiro , Saito Hidehisa , Toyama Hiroaki , Ejima Yutaka , Yamauchi Masanori 
Published: December 2023

Abstract
Background
Tetralogy of Fallot (TOF) is a complex cyanotic congenital heart disease. As most patients with TOF undergo palliative or radical surgical repair during childhood, cardiac surgery under cardiopulmonary bypass (CPB) for adult survivors with unrepaired TOF is exceedingly rare.

Case presentation
A 41-year-old woman with unrepaired TOF, pulmonary atresia (PA), and major aortopulmonary collateral arteries (MAPCAs) developed acute infectious endocarditis (IE). As vegetation gradually increased despite intravenous antibiotic administration, she was scheduled for urgent aortic valve replacement under CPB. Pulmonary blood flow was primarily provided by the MAPCAs originating from the descending aorta. Intra-aortic balloon occlusion for MAPCAs was performed to ensure a bloodless surgical field. Aortic valve replacement was successful.

Conclusion
An adult with uncorrected TOF developed acute IE and subsequently had successful cardiac surgery under CPB. Understanding TOF physiology with PA and MAPCAs, particularly pulmonary blood flow through MAPCAs, is crucial.
Bacterial communication mediated by T4SS effectors
Authors: Xu Lei , Shen Xihui 
Published: December 2023

AbstractBacteria have the ability to inhibit the growth of competitors by using contact-dependent killing devices, such as the bacterial-killing type IV secretion system (T4SS). A recent publication in The ISME Journal by Wang et al. (ISME J, 2023. https://doi.org/10.1038/s41396-023-01533-7) uncovered that T4SS could deliver a unique “non-toxic” effector protein, LtaE, into interspecies bacterial cells. The delivery of LtaE by the bacteria Lysobacter enzymogenes induces the antifungal antibiotic 2,4-DAPG production by binding to the transcriptional repressor PhlF in another bacterial species, Pseudomonas protegens. As a result, P. protegens regains the capacity to protect plants from nearby fungal infections. This finding uncovered a novel role of T4SS in mediating interactions of interkingdom cooperation to kill microbial competitors in soil microbiomes.
Osthole ameliorates myonecrosis caused by Clostridium perfringens type A infection in mice
Authors: Zhang Xueyong , Liu Yue , Shen Zhangqi , Wang Shaolin , Wu Congming , Liu Dejun , Tang Shusheng , Dai Chongshan 
Published: December 2023

AbstractThis study aimed to investigate the protective effect of the nature product osthole (OST) against Clostridium perfringens type A infection-caused myonecrosis in a mouse model. Male mice were divided into (1) control, (2) infected, (3) OST50 and (4) OST100 treatment groups. In the infected groups, mice were intramuscularly injected with 1 × 108 CFU of C. perfringens per day for 6 days. Mice in the OST50 and OST100 groups were administrated intraperitoneally with OST at the doses of 50 or 100 mg/kg per day post C. perfringens infection. Our results showed that C. perfringens infection caused marked necrosis and inflammatory cell infiltration in the muscle tissues of mice. Mice in the OST50 and OST100 treatment groups displayed significantly attenuated C. perfringens infection-induced lipid peroxidation, oxidative stress, and apoptosis in their muscle tissue. Furthermore, OST treatment significantly downregulated the expressions of NF-κB, IL-1β, and TNF-α mRNA and protein levels, while concomitantly upregulating the expressions of Nrf2 and HO-1 mRNA and protein. OST treatments also inhibited the expression of phosphorylation (p)-p38, p-mTOR, and p-Erk1/2 proteins, and upregulated LC3II and Beclin1 proteins. In summary, our results reveal that OST therapy confers a protective effect against C. perfringens infection-induced oxidative stress and inflammation in muscle tissue, via activation of Nrf2/HO-1 and autophagy pathways and inhibition of p38, Erk1/2 and NF-κB pathways.
Toward a Literature of Landed Resistance: Land’s Agency in American Literature, Law, and History
Authors: Keeler Kyle 
Published: December 2023

Abstract
This article draws on Native American theory and archival sources, and colonial archival sources, to reframe land as an agent, partner in cultural production, and ally in resistance to colonialism. The article explains how land structures Haudenosaunee and Mohegan society in narrative and law. It examines how land’s agency appears in the seventeenth- and eighteenth-century Mason Land Case. It does so first from a colonial perspective, where land is inert property and Native peoples are unable to comprehend land as such, then from a Mohegan perspective, where land is a societal member and partner in resisting colonialism. Mohegan recognition of land’s agency and land’s influence on Native resistance is representative of what this essay calls literature of landed resistance. This framework elucidates how Native authors situate their relationships to land in order to move across colonial boundaries, continue active relationships with land in spite of colonialism, and resist colonialism alongside land. Through literature of landed resistance, this article shows how Mohegan leaders Uncas, Appageese, and Samson Occom detail responsibility to land that allows them to represent land’s agency in a manner not seen in settler texts and legislation, and to partner with land in acts of resistance. Understanding land as an active member of society and legislator shows land’s role as an agent and influence in community- and nation-building. (Re)animating land across history opens up new avenues in environmental justice studies to think about history, cultural production, and rights beyond the human and strengthens Native sovereignty through evidence of historic Native relations to land beyond property law.