bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hughes-Stovin syndrome—An important differential diagnosis in patients with suspected chronic thromboembolic pulmonary hypertension
Authors: Pochepnia Svitlana , Lang Irene M. , Milos Ruxandra Iulia , Röhrich Sebastian , Ba-Ssalamah Ahmed , Beer Lucian , Prosch Helmut 
Published: November 2023

SummaryHughes-Stovin syndrome (HSS) is a rare vasculitis of unknown etiology. The disease is characterized by pronounced inflammation and damage to the vessel walls, with subsequent widespread vascular thrombosis and the formation of pulmonary artery aneurysms that can lead to fatal hemoptysis. This disorder can be mistaken for other conditions, such as chronic thromboembolic pulmonary disease (CTEPD) without or with pulmonary hypertension at rest (CTEPH).We report the case of a 20-year-old female with HSS, which was misdiagnosed as CTEPH and subsequently treated with anticoagulants, which led to severe hemoptysis and eventually death of the patient. This case highlights the challenges of diagnosing HSS at early stages of the disease.HSS should be considered in young patients with signs of large vessel vasculitis in combination with thrombotic occlusions of pulmonary arteries, with or without aneurysms of the pulmonary arteries, and particularly, if there are no risk factors for thromboembolic disease.
Die Verschwiegenheitspflicht im psychotherapeutischen Setting unter besonderer Berücksichtigung von virtuellen Angeboten
Authors: Friehs Barbara 
Published: November 2023

ZusammenfassungDie Verschwiegenheitsverpflichtung – ein grundlegendes Gebot in der Psychotherapie – stellt sicher, dass Informationen vertraulich bleiben, um das Vertrauensverhältnis zwischen Klient:innen und Therapeut:innen zu wahren. Mit dem zunehmenden Einsatz von Online-Psychotherapie steigen die Herausforderungen zur Wahrung der Verschwiegenheitsverpflichtung. Ein Vergleich der gesetzlichen Grundlagen für Therapieangebote im virtuellen Raum zwischen Österreich und Deutschland zeigt, dass in Deutschland 30 % aller Behandlungen per Video erlaubt sind. In Österreich ist dieses Format seit den Bestimmungen im Kontext der COVID-19-Pandemie rechtlich ebenfalls zulässig und soll auch nach den Bestimmungen des neuen Psychotherapiegesetzes möglich sein. Zuvor waren dort lediglich psychotherapeutische Beratungsleistungen im Online-Setting erlaubt, nicht jedoch Therapien. Wissenschaftliche Studien weisen zwar auf Problembereiche von virtuellen Settings hin, erbringen aber auch viele Nachweise für einen erfolgreichen Einsatz von psychotherapeutischen Online-Anboten. Da die elektronische Kommunikation potenziell anfällig für Sicherheitsverletzungen ist, müssen Therapeut:innen jedoch angemessene Maßnahmen ergreifen, um das Gebot der Vertraulichkeit und Verschwiegenheit zu gewährleisten. Standardisierte Richtlinien auf internationaler Ebene wären für Online-Therapien wünschenswert, um erhöhte Rechtssicherheit zu schaffen.
Is physiotherapy in migraines known to sufferers? A cross-sectional study
Authors: Tedeschi Roberto , Pillastrini Paolo , Pierangeli Giulia , Favoni Valentina , Cortelli Pietro , Cevoli Sabina 
Published: November 2023

Abstract
Background
Migraine, a prevalent neurological condition, often impairs daily functioning and quality of life. While medications are the primary treatment, the potential of physiotherapy as an integrative approach remains underexplored. The aim of the study was to explore the awareness and experience of migraine patients regarding physiotherapy as a complementary treatment.

Methods
A comprehensive survey was conducted on 200 migraine patients. Data collected included demographics, diagnosis, Migraine Disability Assessment Score Questionnaire (MIDAS) scores, and perceptions and experiences related to physiotherapy.

Results
The average age of participants was 47.7 ± 13.2 years, with a predominance of females, 149 out of 200 (74.5%). The mean MIDAS score was 36.7 ± 45.3, indicating a significant impact on daily life. While 39 out of 200 (19.5%) had undergone physiotherapy for their headache, 161 out of 200 (80.5%) had not. Of those who had, 22 out of 39 (56.4%) reported benefits, including reduced attack intensity and frequency. Interestingly, 145 out of 161 (90.1%) expressed interest in physiotherapy, with many expecting it to reduce attack intensity, 57 out of 200 (28.5%) and frequency, 77 out of 200 (38.5%).

Conclusions
The study highlights the substantial burden of migraines and the potential of physiotherapy as an adjunctive treatment. Increasing awareness and accessibility to physiotherapy could offer migraine patients a more holistic treatment approach; however, randomized controlled trials are mandatory in order to confirm its efficacy.
Mixture of experts distributional regression: implementation using robust estimation with adaptive first-order methods
Authors: Rügamer David , Pfisterer Florian , Bischl Bernd , Grün Bettina 
Published: November 2023

AbstractIn this work, we propose an efficient implementation of mixtures of experts distributional regression models which exploits robust estimation by using stochastic first-order optimization techniques with adaptive learning rate schedulers. We take advantage of the flexibility and scalability of neural network software and implement the proposed framework in mixdistreg, an software package that allows for the definition of mixtures of many different families, estimation in high-dimensional and large sample size settings and robust optimization based on TensorFlow. Numerical experiments with simulated and real-world data applications show that optimization is as reliable as estimation via classical approaches in many different settings and that results may be obtained for complicated scenarios where classical approaches consistently fail.
Effects of dietary commercial phytobiotic “Sanacore® GM” on Pacific white shrimp (Litopenaeus vannamei) growth, immune response, redux status, intestinal health, and disease resistance against Fusarium solani
Authors: Eissa El-Sayed Hemdan , Elbahnaswy Samia , El-Baz Amira Hussein , El-Haroun Ehab , Ashour Mohamed , Mansour Abdallah Tageldein , Saadony Saadea , El-Saeed Adel F. , Kabary Hoda , Jastaniah Samyah D. , Alaidaroos Bothaina A. , Shafi Manal E. , Abd El-Hack Mohamed E. , Eissa Moaheda E. H. , Eldessouki Elsayed A. 
Published: November 2023

AbstractThe use of phytobiotic as functional feed additives is a promising inducer for growth performance and immune response in the Pacific whiteleg shrimp (Litopenaeus vannamei). It can be also commercially applied in combination with chemotherapeutic agents and vaccines. This study was carried out to evaluate the use of a commercial phytobiotic feed additive, Sanacore® GM, containing vegetable fatty acids and inactivated Saccharomyces cerevisiae with herbal extracts, on growth, body composition, non-specific immune response, antioxidant index, intestinal microflora count, and fungal resistance to Fusarium solani challenge in Pacific white shrimp, Litopenaeus vannamei. Shrimp juveniles (5.00 ± 0.1 g) were randomly distributed into 12 hapas (1 m3) in triplicates at a stocking density of 20 shrimp per hapa and fed increasing levels of Sanacore® (0, 0.1, 0.2, and 0.3%) for 63 days. At the end of the feeding trial, the experimental shrimp were infected with F. solani, and mortality was recorded for 15 days. Results revealed that growth performance, feed utilization, and whole-body protein deposition were improved with increasing dietary sanacore levels. A significant improvement was reported in cellular (hemocyte counts, phagocytosis, phagocytic index, respiratory burst activity) and humoral (lysozyme and phenoloxidase) immune responses with higher dietary sanacore levels. Superoxide dismutase, catalase, and glutathione peroxidase were notably improved in shrimp-fed sanacore-supplemented diets. Meanwhile, malondialdehyde level was significantly decreased in all sanacore-supplemented shrimp. Furthermore, the dietary sanacore consistently increased probiotic bacterial counts and decreased enteric and Clostridium sp. counts in the intestine. Juveniles fed with Sanacore exhibited significantly lower mortality rates when challenged with F. solani. In conclusion, dietary sanacore could exhibit a profitable effect on the growth performance, antioxidant capacity, immunity, intestinal microbial, and the health condition of L. vannamei. Thus, sanacore can be used as an attractive feed supplement in the L. vannamei diet (0.2–0.3%), providing more insights into its application in aquaculture as a functional immunostimulant feed additive.
Integrating the Maker pedagogical approach in teacher training: the acceptance level and motivational attitudes
Authors: Quintana-Ordorika Amaia , Camino-Esturo Edorta , Portillo-Berasaluce Javier , Garay-Ruiz Urtza 
Published: November 2023

AbstractIn recent years, Maker Education has gained popularity in formal education, but the perceptions of pre-service teachers after participating in a maker training program at a university-based makerspace remain to be explored. The purpose of this study is to analyze the acceptance level and the degree of motivation of pre-service teachers towards the maker educational approach. The research assesses attention, relevance, confidence and satisfaction according to Keller's motivational model, as well as the acceptance of the maker approach using the Technology Acceptance Model (TAM). The study focuses on Early Childhood Education pre-service teachers from UPV/EHU (University of the Basque Country) who have been involved in designing teaching and learning plans based on Maker Education. The results show a strong motivation among the pre-service teachers in terms of attention, relevance, confidence and satisfaction towards the maker approach. The study also highlights a high level of technology acceptance. These findings underline the positive impact of maker-based learning methods and suggest that greater motivation correlates with the positive attitudes towards integrating this pedagogy in the future. In light of these findings, integrating innovative maker pedagogy into teacher training appears to be beneficial, as the high levels of acceptance and motivation indicate its potential to equip students with essential twenty-first century skills.
The Right to Break the Law? Perfect Enforcement of the Law Using Technology Impedes the Development of Legal Systems
Authors: Custers Bart 
Published: November 2023

AbstractTechnological developments increasingly enable monitoring and steering the behavior of individuals. Enforcement of the law by means of technology can be much more effective and pervasive than enforcement by humans, such as law enforcement officers. However, it can also bypass legislators and courts and minimize any room for civil disobedience. This significantly reduces the options to challenge legal rules. This, in turn, can impede the development of legal systems. In this paper, an analogy is made with evolutionary biology to illustrate that the possibility to deviate from legal rules and existing norms is sometimes necessary for the further development of legal systems. Some room to break the law, for instance, through civil disobedience or imperfect enforcement of the law, will ensure sufficient variation. This allows for properly evolving legal systems that can continue to provide fair solutions, even when society and concepts of fairness further develop.
Beautiful, Magic, Lethal: a Social Perspective of Cinnabar Use and Mercury Exposure at the Valencina Copper Age Mega-site (Spain)
Authors: García Sanjuán Leonardo , Montero Artús Raquel , Emslie Steven D. , Lozano Rodríguez José Antonio , Luciañez-Triviño Miriam 
Published: November 2023

AbstractToday, mercury is a matter of concern for health and environmental authorities across western countries, and legislation has been passed and programs have been implemented for its total elimination from human activity. But this was not always the case: mercury and its compounds have been highly appreciated and used since remote times all over the world with very diverse purposes ranging from decorative, medicinal, metallurgical and symbolic. In particular, cinnabar (HgS, mercury sulfide), a mineral of an intense red color, has been considered in many cultures as an exotic raw material, highly valued and associated with the elites and sacred practice. In this paper, we examine one such case, set almost 5000 years ago, in Copper Age Iberia, by investigating mercury exposure through human bone. The study presented here includes a total of 170 samples from 70 different human individuals and 22 animals (plus one soil sample) from the Copper Age mega-site of Valencina, south-western Spain. It is the largest ever single-site study of exposure to mercury based on human bone in combination with cinnabar use. Abnormally high values are recorded in some individuals dating between 2900 and 2650 BC, especially in those buried in remarkable tombs belonging to the social elite of this period, but high levels of mercury are also recorded in the rest of the population. Three lines of interpretation are used to explain these results, including the manipulation of cinnabar (grinding it into powder, mixing it with other substances, using it for the decoration of objects, buildings and the human body), its direct consumption through ingestion or inhalation by a ‘special’ social group and the contribution of environmental factors. Based on the currently available evidence, which is carefully reviewed, Valencina represents the most intense and prolonged case of exposure to mercury recorded in human history, which makes it an important site to assess the long and complex history of use of this substance.
Refining the mechanistic understanding of microstructural decay during rolling contact fatigue in 52100 bearing steel tempered at high temperature
Authors: Loaiza Tania , Babu R. Prasath , Ooi Steve , Hedström Peter 
Published: November 2023

AbstractSubsurface rolling contact fatigue (RCF) failure occurs beneath heavily loaded hard contacts like gears, bearings, and cams. This study investigates microstructural decay beneath a RCF-tested surface in AISI/SAE 52100 bearing steel tempered at 240 ℃. RCF tests were conducted at 100 ℃ with a maximum Hertzian contact pressure of 4 GPa for four stress cycles. Microstructural characterization utilized scanning electron microscopy, electron backscatter diffraction, transmission Kikuchi diffraction, and transmission electron microscopy. Due to high tempering temperature, white etching bands (WEBs) were observed without preceding dark etching regions. The microstructural decay sequence involved: (1) formation of elongated ferrite and ferrite microbands, (2) complete dissolution of tempered carbides and partial dissolution of residual cementite, (3) formation of WEBs composed of nano-sized ferrite grains (100–300 nm) transformed from ferrite microbands, and (4) appearance of lenticular carbides. Within the WEBs, most nano-sized grains had high-angle grain boundaries, while the fraction of low-angle grain boundaries increased in later stages of RCF. Lenticular carbides formed alongside elongated ferrite and coalesced nano-sized ferritic grains.
Efficient determination of the accessible conformation space of multi-domain complexes based on EPR PELDOR data
Authors: Kazemi Sina , Lopata Anna , Kniss Andreas , Pluska Lukas , Güntert Peter , Sommer Thomas , Prisner Thomas F. , Collauto Alberto , Dötsch Volker 
Published: November 2023

AbstractMany proteins can adopt multiple conformations which are important for their function. This is also true for proteins and domains that are covalently linked to each other. One important example is ubiquitin, which can form chains of different conformations depending on which of its lysine side chains is used to form an isopeptide bond with the C-terminus of another ubiquitin molecule. Similarly, ubiquitin gets covalently attached to active-site residues of E2 ubiquitin-conjugating enzymes. Due to weak interactions between ubiquitin and its interaction partners, these covalent complexes adopt multiple conformations. Understanding the function of these complexes requires the characterization of the entire accessible conformation space and its modulation by interaction partners. Long-range (1.8–10 nm) distance restraints obtained by EPR spectroscopy in the form of probability distributions are ideally suited for this task as not only the mean distance but also information about the conformation dynamics is encoded in the experimental data. Here we describe a computational method that we have developed based on well-established structure determination software using NMR restraints to calculate the accessible conformation space using PELDOR/DEER data.
The effect of consanguineous marriage on reading disability based on deep neural networks
Authors: Talaat Fatma M. 
Published: November 2023

AbstractFor knowledge acquisition and social engagement, reading comprehension is essential. However, 20% or so of younger students have trouble with it. In order to predict the effects of consanguineous marriage on reading handicap and customize adaptive learning experiences, the study proposes an Intelligent Adaptive Learning and Prediction Framework (IALPF). This framework is proposed as a transformative solution that smoothly combines cutting-edge AI approaches. IALPF provides precise predictions and individualized learning pathways by utilizing extensive cognitive profiling, data gathering, and hybrid neural network design. It includes early warning systems, flexible content distribution, and ongoing development based on active learning and feedback loops. The IALPF represents a significant change in education that has wide-ranging effects. We evaluated reading skills among 770 students in a study that included two experimental groups, a control group, and 22 pupils from first-cousin marriages and 21 children of unrelated parents, respectively. Tests were given for word identification and reading comprehension, among other things. The findings showed that children of first cousin parents had a higher chance of reading difficulties than those of parents from other families. The outstanding performance of IALPF, which outperformed conventional techniques like Back Propagation (BP) and General Regression Neural Network (GRNN), was further supported by empirical evaluation. This demonstrates IALPF's success in reinventing personalized learning and predictive analysis, strengthening its potential to improve education in a variety of scenarios. The seamless integration of cutting-edge AI methods into IALPF, which forecasts the effect of consanguineous marriage on reading handicap, is a significant innovation. To set it apart from conventional approaches, this special framework integrates cognitive profile, information gathering, and hybrid neural networks for accurate predictions. The empirical analysis demonstrates the revolutionary potential of IALPF by demonstrating its improved predictive accuracy when compared to Back Propagation (BP) and General Regression Neural Network (GRNN).
Assessing Religious Leadership: A Scoping Review of Leadership Effectiveness Criteria and Current Trends in the Academic Literature
Authors: Foppen Annemarie , van Saane Joke W. 
Published: November 2023

AbstractA clear understanding of what constitutes effective religious leadership in the context of faith communities is essential for religious practitioners, religious communities, and educational institutes. Twenty-five years after the latest review study by Nauss, an updated overview is needed to account for new insights, especially regarding the latest developments in leadership research and the changing religious landscape. A scoping review was conducted in four databases from 1997 to 2022 to examine the academic literature. The search identified 64 unique references that researched effective religious leadership using 27 different effectiveness criteria. These criteria were categorized based on their target of evaluation: (1) the religious leader, (2) followers/members, and (3) the congregation. Although most references assessed leadership effectiveness by evaluating the religious leader, the most used effectiveness criterion was ‘attendance or numerical growth.’ Over the last 25 years, the criteria for religious leadership effectiveness have become more diverse, and a growing number of references combine criteria from multiple targets to evaluate effectiveness. However, the focus on Christian leadership remains prevalent in the academic literature. The present overview is intended as a starting point for future research as it identifies the current trends and existing knowledge gaps. The study’s findings also invite religious practitioners and congregations to reflect on their methods of assessing leadership effectiveness.
Seasonal variation in urban pollen resource use by north temperate European honeybees
Authors: Davey Marie L. , Blaalid Rakel , Dahle Sondre , Stange Erik E. , Barton David N. , Rusch Graciela M. 
Published: November 2023

AbstractUrban green infrastructure can provide important habitats for pollinators and support urban ecosystem services. Therefore, these areas must be managed to maximize biodiversity and density of pollinating insects. We used DNA metabarcoding to study honeybee pollen resource use over time and space in the city of Oslo, Norway, and to assess the role of green infrastructure as a resource for pollinators and the services they generate. Urban honeybees used diverse pollen resources throughout their active season. There was considerable seasonal turnover in pollen resource use that reflected flowering phenology. Non-native plants (including invasive species) were an important resource early in the season but were replaced by native plants later in the season. Hive location was not strongly correlated with resource use, likely indicating effective long-distance foraging in the fragmented urban landscape. However, flower visitation rates and floral resource density in public urban green spaces were coupled to pollen use. Honeybees collected pollen from a small number of preferred species but also visited other species, likely for nectar. To preserve pollinator services, urban planning should consider flower resource management, with particular focus on planting native species that can act as early season resources for bees. Public campaigns and other incentive mechanisms to promote the cultivation of native plants that are resources for pollinators and the protection of urban semi-natural habitats have the potential to enhance the value of green infrastructure to support urban pollinators and pollination services.