bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preferences for Long-Acting PrEP Products Among Women and Girls: A Quantitative Survey and Discrete Choice Experiment in Eswatini, Kenya, and South Africa
Authors: Little Kristen M. , Hanif Homaira , Anderson Sharon M. , Clark Meredith R. , Gustafson Kiira , Doncel Gustavo F. 
Published: November 2023

AbstractWhile oral pre-exposure prophylaxis (PrEP) can substantially reduce HIV risk, there are important barriers to uptake and adherence. We explored preferences for long-acting injectable and implantable PrEP among women and girls in Eswatini, Kenya, and South Africa. We conducted an online quantitative survey and discrete choice experiment (DCE) among adolescent girls (15–17), young women (18–29), and adult women (30–49). Participants completed a survey about their demographics and behavior and a DCE with 5 attributes (format, insertion location, number of insertions, dual-protection, and palpability). We recruited 1236 respondents (Eswatini = 420; Kenya = 350; South Africa = 493) in May 2022. Most participants were sexually active (72%), nearly 29% of whom reported recently engaging in transactional sex. 46% had heard of oral PrEP, but of those, only 16% reported having ever used it. Product format and dual-protection were significant predictors of product choice. Relative to a 2-month injection, participants had 1.76 times the odds (95% CI 1.08–2.04) of choosing a 6-month injectable, and 1.70 the odds (95% CI 1.06–1.92) of choosing a 12-month removable implant. Compared to a single-indication product, respondents had 2.46 times the odds (95% CI 1.04–2.68) of preferring a product also protecting against pregnancy, and 2.81 the odds (95% CI 1.04–3.05) of choosing a product that also protected against STIs. Adolescent girls and women in these countries showed strong preferences for longer-acting PrEP product formats, as well as those offering dual-protection. Introduction of long-acting options could improve PrEP uptake and reduce HIV burdens in east and southern African settings.
Optimal reimbursement limitation for a health plan
Authors: Baione Fabio , Biancalana Davide , Menzietti Massimiliano 
Published: November 2023

AbstractThe goal of this paper is the assessment of an optimal reimbursement strategy for employer-based health insurance plans (HP), that cover several categories of medical services. Indeed, a health plan may offer several cost-sharing provisions for these categories, and the “Percent Expense Paid” by the plan also known as “Actuarial Value” represents a summary measure of the protection provided. Starting from a wide industrial applied model in insurance for rate-making, the generalized linear models (GLM), we estimate the expected value and variance of the health expenditure for each category. Moreover, different reimbursement rules (e.g. deductibles, co-payments, policy limits, etc.) involve a change of the “Actuarial Value” calculated as the ratio between the benefits paid by the plan (i.e. reimbursement amounts) and the expenses paid by policyholders (i.e. expenditures). The latter is the percentage of expenditure reimbursed by the plan and is sometimes defined in actuarial literature as Indicated Deductible Relativity (IDR); an IDR can be calculated for each category covered by the Health Plan or per policyholder and is a commonly used method for scoring the benefits of health insurance. Hence, we calculate the optimal IDR for each category, using the optimization problem proposed by de by Finetti (Il problema dei pieni, Giornale dell’istituto italiano degli attuari, 1940) in the context of proportional reinsurance. The goal is the minimization of the variance of the total reimbursement of the Health Plan by fixing the total gain. Furthermore, we propose a numerical application to a real dataset, containing observed expenditures of an Italian HP.
A robust route to randomness in a simple Cournot duopoly game where ambiguity aversion meets constant expectations
Authors: Radi D. , Gardini L. , Goldbaum D. 
Published: November 2023

AbstractIn this paper we investigate the dynamics of a duopoly game with ambiguity aversion regarding uncertainty in demand and constant expectations concerning competitor production. The focus is on an asymmetric Cournot game where players engage in robust optimization and have different beliefs about the possible realizations of the random parameters of the price function. The players’ ambiguity aversion introduces multiple equilibria and instability that otherwise would not be present. The investigation of the global dynamics of the game reveals the emergence, through border-collision bifurcations, of periodic and chaotic dynamics.
Tick infestation in spur-thighed tortoise population: a pilot study for unraveling epidemiological patterns and demographic consequences
Authors: Segura Amalia , Rafael Marta , Vaz-Rodrigues Rita , Rodríguez Oscar , Gortázar Christian , de la Fuente José 
Published: November 2023

AbstractEctoparasites, such as ticks, modulate host population dynamics by impacting demographic traits. They transmit infectious agents among their hosts, posing a critical threat to animal and public health. This study aimed to characterize and analyze the Hyalomma aegyptium infestation on one of its main hosts, the spur-thighed tortoise, its effects on demographic traits, and to determine the diversity of infectious agents present in both ticks and tortoises in the Maamora forest (northwestern Morocco). Our results show that 100% of the tortoises were parasitized by adult ticks in spring, an infestation intensity of 4 ticks/tortoise (5.1 and 3.6 ticks/tortoise in males and females, respectively; 4.2 and 3.3 ticks/tortoise in gravid and non-gravid females, respectively) and an abundance ranging from 1 to 12. Although without significant differences, male tortoises had higher tick abundances than females. The interaction of tortoise sex and body condition was significantly related to tick abundance, male body condition decreased with higher tick abundance in contrast to females. Nevertheless, the interaction of body condition and reproductive stage of females was not significantly related to tick abundance. Gravid females were significantly associated with tick abundance, showing a slightly higher infestation than non-gravid females. Molecular analysis of pooled tick samples revealed the presence of Ehrlichia ewingii, Candidatus Midichloria mitochondrii, and Rickettsia africae, with a minimum infection rate of 0.61 to 1.84%. However, blood sample analysis of the tortoises was infectious agent-free, pinpointing a lack of significant health problems. Given the possible effect on the transmission of zoonotic diseases by spur-thighed tortoises associated with their frequent collection as pets, it should be surveyed to control possible human health problems. In conservation terms, as a long-lived species, the role of tick infestation in demographic traits might be included in the management and conservation programs of spur-thighed tortoises.
Integral Turbulent Length and Time Scales of Higher Order Moments
Authors: Klein Markus 
Published: November 2023

AbstractTurbulent length and time scales represent a fundamental quantity for analysing and modelling turbulent flows. Although higher order statistical moments have been conveniently used for decades to describe the mean behaviour of turbulent fluid flow, the definition of the integral turbulent scales seems to be limited to the velocity or its fluctuation itself (i.e. the first moment). Higher order moments are characterized by smaller integral scales and a framework is proposed for estimating autocorrelation functions and integral turbulent length or time scales of higher order moments under the assumption that the probability distribution of the velocity field is Gaussian. The new relations are tested for synthetic turbulence as well as for DNS data of a turbulent plane jet at Reynolds number 10000. The present results in particular suggest that the length or time scales of higher order moments can be markedly smaller than those of the turbulent variable itself, which has implications for statistical uncertainty estimates of higher order moments.
Small villages and their sanitary infrastructure—an unnoticed influence on water quantity and a threat to water quality in headwater catchments
Authors: Spill Caroline , Ditzel Lukas , Gassmann Matthias 
Published: November 2023

AbstractIn rural catchments, villages often feature their own, separate urban water infrastructure, including combined sewer overflows (CSOs) or wastewater treatment plants (WWTPs). These point sources affect the water quantity and quality of the receiving low order streams. However, the extent of this impact is rarely monitored. We installed discharge and water quality measurements at the outlet of two small, neighbouring headwater catchments, one that includes a village, a WWTP, and two CSOs, while the other is predominantly influenced by agricultural activities. We also deployed electrical conductivity (EC) loggers at the CSOs to accurately detect discharge times. Discharge from the WWTP and CSOs led to higher peak flows and runoff coefficients during events. Less dilution of EC and increasing ammonium-N (NH4 − N) and ortho-phosphorus (oPO4 − P) concentrations indicate a significant contribution of poorly treated wastewater from the WWTP. During CSO events, water volumes and nutrient loads were clearly elevated, although concentrations were diluted, except for nitrite-N (NO2 − N) and particulate phosphorus (PP). Baseflow nitrate-N (NO3 − N) concentrations were diluted by the WWTP effluent, which led to considerably lower concentrations compared to the more agriculturally influenced stream. Concentrations of oPO4 − P, NH4 − N, and NO2 − N, which are most likely to originate from the WWTP, vary throughout the year but are always elevated. Our study shows the major and variable impact rural settlements can have on stream hydrology and water quality. Point sources should be monitored more closely to better understand the interaction of natural catchment responses and effects caused by sanitary infrastructure.
Marginal increase in nitrate leaching under grass–clover leys by slurry and mineral fertilizer
Authors: Fontaine Doline , Rasmussen Jim , Eriksen Jørgen 
Published: November 2023

AbstractOn dairy farms, fertilization of grass-clover swards ensures stable grass yields but may increase the potential for nitrate leaching on light-textured soils. The aim of this study was to quantify the N use efficiency and nitrate leaching under fertilized grass-clover leys. The study was conducted over 2 years at two sites, with increasing applications of mineral fertilizer (0–480 kg available N ha−1) alone or in combination with a basic application of cattle slurry. For plots fertilized with mineral N, the N soil surface balance was independent of the application rate and in the same range as for unfertilized plots (− 11 to 51 kg N ha−1). However, when plots were fertilized with slurry N (+ mineral N), the surplus was substantially increased owing to the fraction of organic N applied in slurry (95–100 kg N ha−1) and higher biological N2 fixation inputs (55–228 kg N ha−1). The type of fertilizer had no effect on nitrate leaching across the full range of application rates. Nitrate leaching increased quadratically as a function of application rate, with a range of 3–117 kg N ha−1 (0.33–17 mg l−1 in soil solution sampled with suction cups) in the first year and less in the second year, when clover proportion was lower due to the self-regulatory nature of grass-clover mixtures. Importantly, the rate of marginal leaching increased with fertilization level: below 150 kg N ha−1 there was no additional leaching from fertilization and at 200 kg N ha−1 around 5% of additional fertilizer-N was leached. This is less than generally found for arable crops and thus even in intensive dairy systems, grass-clover leys are an environmentally favorable crop.
CO2 elevation modulates the growth and physiological responses of soybean (Glycine max L. Merr.) to progressive soil drying
Authors: Cui Bingjing , Liu Jie , Zhang Manyi , Wan Heng , Wei Guiyu , Wei Zhenhua , Liu Fulai 
Published: November 2023

AbstractUnderstanding the impact of future climates on crop performance is essential for sustainable agricultural production. In the current research, the development and biological behavior of soybean plants during gradual desiccation of the soil (from the 100% of pot water holding capacity to the gs of plant decreased to 10% of that of the control plants) at ambient [CO2] (a[CO2], 400 ppm) and elevated [CO2] (e[CO2], 800 ppm) were investigated. The results showed that plants grown under e[CO2] conditions had remarkably higher photosynthetic rate (An) but lower stomatal conductance (gs) and transpiration rate (E) compared to plants at a[CO2] conditions, which led to an enhanced water use efficiency at both stomatal (WUEi) and leaf levels (WUEleaf). In addition, the e[CO2]-grown soybeans showed a stunted gs response to progressive soil drying, coinciding with a decrease in the susceptibility of gs to the ABA signaling, though they tended to maintain a better leaf water status under drought than the a[CO2]-grown plants. Although the leaf nitrogen concentration (Nleaf) and the total plant N content were notably lower at the e[CO2] condition, the specific leaf N content (SLN) was similar at different [CO2] conditions. Compared to soybean grown under e[CO2], the greater number of nodules at e[CO2] treatment would lead to an enhanced N-fixation, yet, it did not improve the N nutrition of the plants. Nevertheless, by sustaining the SLN, the soybean plants enhanced An when growing at e[CO2], particularly under dry conditions. This knowledge is essential for sustaining soybean production in future climate change scenarios.
Bisequent Calculus for Four-Valued Quasi-Relevant Logics: Cut Elimination and Interpolation
Authors: Indrzejczak Andrzej 
Published: November 2023

AbstractWe present a uniform syntactical characterisation of the class of quasi-relevant logics which are four-valued extensions of the basic relevant logic B of Meyer and Routley. All these logics are obtained by the addition of suitable quasi-relevant implications to the four-valued logic of First Degree Entailment FDE. So far they were characterised axiomatically and semantically in several ways but did not obtain a special proof-theoretic treatment. To this aim a generalised form of sequent calculus called bisequent calculus (BSC) is applied. In BSC rules operate on the ordered pairs of ordinary sequents. It may be treated as the weakest kind of system in the rich family of generalised sequent calculi operating on items which are some collections of ordinary sequents, like hypersequents or nested sequents. It is shown that all logics under consideration have cut-free characterisation in BSC which satisfies the subformula property and yields decidability. It is also shown that the interpolation theorem holds for these logics if their language is enriched with additional negation.
Dwelling by appropriation: identity and attachment in low-income housing in Monterrey, Mexico
Authors: Elizondo Lucia 
Published: November 2023

AbstractMexico's housing policies and institutions have focused on increasing the housing supply over the past 50 years. Despite this, most of the population has been unable to afford it and has been forced to fend for themselves through self-construction in socially produced neighborhoods. This research compares the difference between inhabiting a "turn-key" house provided by the state and a self-constructed house through the lens of appropriation and its effects on identity and place attachment that evidence the co-constitutive nature of the house/resident dynamic. As case studies, thirty houses were analyzed in six neighborhoods, three state-financed and three socially produced. The empirical data collected through the qualitative study was structured through the development of a theoretical model called "dwelling by appropriation" that attempts to describe the practices surrounding the appropriation of the home. The research found that individuals who construct their own homes are prouder of them, more satisfied with them, have a higher sense of self-esteem and self-efficacy, and are more trusting of their neighbors as they are in control of critical decisions regarding their living environment.
Health Technology Readiness amongst Patients with Suspected Breast Cancer Using the READHY-tool - a Cross-sectional Study
Authors: Sollie Martin , Hansen Marianne , Thomsen Jørn Bo 
Published: November 2023

AbstractInformation technologies are increasingly used when informing patients about their disease, treatment and prognosis. These digital platforms have many advantages compared to traditional education interventions. However, there are concerns that some patients may have difficulty with this mode of information delivery. Newly diagnosed breast cancer patients are dependent on understanding their treatment options to make informed treatment decisions. Yet, there is a lack of published material on breast cancer patients and their relationship with technology. We aimed to assess health technology readiness profiles amongst women with a suspected breast cancer diagnosis. Secondly, we wanted to investigate the potential differences between these profiles according to sociodemographic factors and the patients´ current use of technology. This cross-sectional study used the Readiness and Enablement Index for Health Technology (READHY) questionnaire. We included all patients (n = 92) referred to our department with suspected breast cancer. Cluster analysis revealed three distinct profiles: medium (n = 54), high (n = 18), and low (n = 20) health technology readiness. The third profile showed difficulties in health literacy, eHealth literacy, and health insights, along with higher emotional stress. Our study found that most patients had medium to high health technology readiness, but we also identified a group with lower health technology readiness. Based on our results, healthcare personnel dealing with women with suspected breast cancer should be aware of patients struggling with health technology. Age and technology familiarity may indicate vulnerable patients. Future studies should explore optimal methods for information delivery to these distinct profiles and evaluate the long-term impacts.
How foes become allies: the shifting role of business in climate politics
Authors: Vormedal Irja , Meckling Jonas 
Published: November 2023

AbstractFirms often oppose costly public policy reforms—but under what conditions may they come to support such reforms? Previous scholarship has taken a predominantly static approach to the analysis of business positions. Here, we advance a dynamic theory of change in business policy positions that explains how business may shift from opposing to supporting new regulation over the course of multiple rounds of policymaking. We identify three sets of drivers and causal mechanisms behind business repositioning related to political, policy, and market change. We argue that political mechanisms can shift opposition to “strategic support” for reform, whereas policy and market mechanisms may shift opposition or strategic support toward “sincere support.” We examine the reconfiguration of business interests and policy positions in the context of three decades of US climate politics, focusing on the oil and gas, electricity, and auto sectors. Our dynamic theory of business positions moves beyond the dualism that views business as either opposing or supporting public interest regulation. We thus advance our understanding of why initial business opposition can incrementally turn into strategic or sincere support for policy reform.
Association of Remote Patient Monitoring with Mortality and Healthcare Utilization in Hypertensive Patients: a Medicare Claims–Based Study
Authors: Acharya Mahip , Ali Mir M. , Bogulski Cari A. , Pandit Ambrish A. , Mahashabde Ruchira V. , Eswaran Hari , Hayes Corey J. 
Published: November 2023

Abstract
Background
Hypertension management is complex in older adults. Recent advances in remote patient monitoring (RPM) have warranted evaluation of RPM use and patient outcomes.

Objective
To study associations of RPM use with mortality and healthcare utilization measures of hospitalizations, emergency department (ED) utilization, and outpatient visits.

Design
A retrospective cohort study.

Patients
Medicare beneficiaries aged ≥65 years with an outpatient hypertension diagnosis between July 2018 and September 2020. The first date of RPM use with a corresponding hypertension diagnosis was recorded (index date). RPM non-users were documented from those with an outpatient hypertension diagnosis; a random visit was selected as the index date. Six months prior continuous enrollment was required.

Main Measures
Outcomes studied within 180 days of index date included (i) all-cause mortality, (ii) any hospitalization, (iii) cardiovascular-related hospitalization, (iv) non-cardiovascular-related hospitalization, (v) any ED, (vi) cardiovascular-related ED, (vii) non-cardiovascular-related ED, (viii) any outpatient, (ix) cardiovascular-related outpatient, and (x) non-cardiovascular-related outpatient. Patient demographics and clinical variables were collected from baseline and index date. Propensity score matching (1:4) and Cox regression were performed. Hazard ratios (HR) and 95% confidence intervals (CI) are reported.

Key Results
The matched sample had 16,339 and 63,333 users and non-users, respectively. Cumulative incidences of mortality outcome were 2.9% (RPM) and 4.3% (non-RPM), with a HR (95% CI) of 0.66 (0.60–0.74). RPM users had lower hazards of any [0.78 (0.75–0.82)], cardiovascular-related [0.79 (0.73–0.87)], and non-cardiovascular-related [0.79 (0.75–0.83)] hospitalizations. No significant association was observed between RPM use and the three ED measures. RPM users had higher hazards of any [1.10 (1.08–1.11)] and cardiovascular-related outpatient visits [2.17 (2.13–2.19)], while a slightly lower hazard of non-cardiovascular-related outpatient visits [0.94 (0.93–0.96)].

Conclusions
RPM use was associated with substantial reductions in hazards of mortality and hospitalization outcomes with an increase in cardiovascular-related outpatient visits.
A mixed-method approach to investigate the public acceptance of drones
Authors: Stolz Maria , Papenfuss Anne , de Albuquerque Richers Georgia Cesar , Bahnmüller Anna , Syed Azeem Muhammad , Gerndt Andreas , Fischer Martin , Wegener Jan , Lieb Teemu Joonas , Biella Marcus 
Published: November 2023

AbstractDrones may play an essential role in future traffic. As with every innovation, not only is the technical maturity decisive for its success, but also whether the general public will accept it. This paper uses a mixed-method approach combining quantitative and qualitative methods to investigate social acceptance concerning drones. The study included 20 participants and comprised a virtual simulation, a team task, and a group discussion. This way, different aspects of drone acceptance were investigated. On the one hand, a simulative approach was tested to explore the visual perception of drone flights in an urban setting. On the other hand, the acceptance of various drone applications such as civil protection, parcel delivery, and air taxis was studied. Furthermore, this research identified requirements for coordinating and managing future drone traffic. This paper combines two acceptance models from the literature as a theoretical framework: an adoption of Chamata’s and Winterton’s Technical Acceptance Model by Krempel and the Unacceptability–Acceptance Scale by Hofinger.