bluuebunny/crossref_metadata_2025_split huggingface dataset:
HyperCVAD versus pegaspargase‐containing regimens for Hispanic adults with newly diagnosed B‐cell acute lymphoblastic leukemia
Authors: Lee Benjamin J. , Griffin Shawn P. , Doh Jean , Chan Alexandre , Ciurea Stefan O. , Jeyakumar Deepa , Fleischman Angela G. , Naqvi Kiran , Pannunzio Nicholas R. , O’Brien Susan , Kongtim Piyanuch 
Published: November 2023

AbstractObjectiveThere are significant disparities in outcomes among Hispanic patients with acute lymphoblastic leukemia (ALL). Recent studies have demonstrated favorable outcomes of pegaspargase‐containing ALL regimens (PEG‐CAR) in young adults however, outcomes in Hispanic ethnicity continue to be underreported.MethodsWe evaluated outcomes of newly diagnosed, adult B‐cell ALL Hispanic and non‐Hispanic patients consecutively treated with a PEG‐CAR or HyperCVAD between January 2011 and November 2022. The primary endpoint was event‐free survival (EFS) while secondary endpoints included cumulative incidence of relapse and overall survival (OS).ResultsAmong 105 included patients, 48 (45.7%) were treated with a PEG‐CAR and 57 (54.3%) with HyperCVAD. Median age was 38 years (range, 18–75 years), 61% were Hispanic, and 35.2% had poor‐genetic risk. Hispanic patients demonstrated significantly worse 5‐year EFS with a PEG‐CAR compared to that seen with HyperCVAD (HR, 2.58; 95% CI, 1.32–5.04; p = .006) whereas non‐Hispanic patients had better outcomes with PIR (52.4% vs. 42.0%). Hispanic ethnicity (p = .015) and male sex (p = .019) were independent predictors for poor OS.ConclusionsHispanic patients with B‐cell ALL had worse EFS with a PEG‐CAR as compared with HyperCVAD. Future studies will aim to confirm these findings and establish a tailored treatment approach for this high‐risk population.
Plasticity occurs in a specific phenotype of neurons in the nucleus tractus solitarius of dystrophin gene‐mutated rats
Authors: Chikamoto Akitoshi , Tochinai Ryota , Sekizawa Shin‐ichi , Kuwahara Masayoshi 
Published: November 2023

AbstractDuchenne muscular dystrophy (DMD) is a severe progressive neuromuscular disorder that causes cardiac and respiratory failure. Patients with DMD have tachycardia and autonomic nervous dysfunction at a young age, which can potentially worsen cardiorespiratory function. Therefore, we hypothesised that plasticity occurs in neurons of the cardiorespiratory brainstem nucleus (nucleus tractus solitarius [NTS]) due to DMD, thus affecting neuronal regulation because afferent information from cardiorespiratory organs changes with disease progression. Patch‐clamp experiments were performed on second‐order NTS neurons from Dmd‐mutated (Dm) rats that showed no functional dystrophin protein expression, as confirmed by immunohistochemistry. NTS neurons are classified into two electrophysiological phenotypes: one showing a delayed onset of spiking from hyperpolarised membrane potentials, namely, delayed‐onset spiking (DS)‐type neurons, and the other showing a rapid onset, namely, rapid‐onset spiking‐type neurons. Neuroplasticity mainly occurs in DS‐type neurons in Dm rats and is characterised by blunted neuronal excitability accompanied by reduced outward currents and a facilitatory effect on synaptic transmission, that is, an increased frequency of spontaneous and miniature excitatory postsynaptic currents (EPSCs) without changes in the amplitude and an increased amplitude of tractus solitarius‐evoked EPSCs without changes in the paired‐pulse ratio. Although we cannot rule out the possibility that the neuroplastic changes observed in Dm rats were caused by dystrophin deficiency in the neurons themselves, the plasticity could be caused by cardiorespiratory deterioration and/or adaptation in DMD patients.
Parents' experiences of parenting a child with profound intellectual and multiple disabilities in France: A qualitative study
Authors: Aim Marie‐Anastasie , Rousseau Marie‐Christine , Hamouda Ilyes , Anzola Any Beltran , de Villemeur Thierry Billette , Milh Mathieu , Maincent Kim , Lind Katia , Auquier Pascal , Baumstarck Karine , Dany Lionel 
Published: November 2023

AbstractIntroductionParents of persons with profound intellectual and multiple disabilities (PIMD) play a major and often lifelong role in the care and support of their child. A better understanding of parents' perspectives regarding their experiences of parenting their child with PIMD is essential to support them more effectively. Although this topic has been explored extensively in Anglo‐Saxon and Northern European countries, little is known about the experience of these parents in a highly institutionalized context such as that in France.ObjectiveWe explored parents' experiences of the activities they performed to care for their child with PIMD (namely, the ‘parenting work’) in the French context.MethodQualitative semistructured interviews were conducted by telephone with 34 parents of persons with PIMD aged 8–35. The resulting data were analyzed using thematic analysis.ResultsThe analysis highlighted the diversity of activities performed by parents as well as the influence of context on the forms of this parenting work. Five themes were developed: (1) navigating the challenges of obtaining medical recognition; (2) negotiating a concealed domain and becoming an expert; (3) unfolding medical and medicosocial care management; (4) navigating the challenges of daily living and (5) shaping one's child's possibilities.ConclusionThis study offers a better understanding of the challenges, levers and expectations of parents of children with PIMD in France. Contextual factors such as the lack of knowledge of PIMD among health professionals, access to knowledge and know‐how associated with care management, the administrative complexity of access to care and equipment, institutional issues (e.g., professional turnover) and societal ableism (e.g., access to infrastructures, interpersonal discrimination) shape the work parents perform to support their child's needs. It is necessary to consider contextual aspects to better support these parents and their children. Suggestions for applications are provided in the discussion.Patient or Public ContributionOne of the researchers, a parent of a child with PIMD, supported the research design and provided feedback on the study's procedures and manuscript.
Persistence as a multidimensional construct: A new insight into the multidimensional persistence scale
Authors: Pajestka Grzegorz , Poraj‐Weder Magdalena 
Published: November 2023

AbstractPersistence, defined as a trait‐like characteristic, reflects the personal tendency to endure different hardships. In a recently developed model, three dimensions—persistence despite difficulties, persistence despite fear, and inappropriate persistence—were proposed to cover distinct facets of this ability, along with goal‐time preferences as a persistence‐related construct. The Multidimensional Persistence Scale (MPS) and the Goal‐Time Preferences Scale (GTPS) were created to gauge these two separate constructs. In the current study, we conducted two studies using the Polish version of the scales (MPS‐PL and GTPS‐PL, respectively), with the aim of evaluating both measures. We also proposed a profile model as better reflecting the multidimensionality of persistence as opposed to the original superordinate model. In Study 1, the three‐factor structure of the MPS‐PL was supported by a confirmatory factor analysis. In contrast, the GTPS‐PL showed a poor fit to the data as well as a vague factor structure. In Study 2, we tested the nomological network of the MPS‐PL, providing evidence for its construct validity as well as the distinctiveness of its dimensions. Finally, we conducted a latent profile analysis, which revealed the three qualitatively different configurations of persistence dimensions in the total study sample. Overall, the evidence we gathered supports our proposal about persistence as a multidimensional profile construct.
Molecular dynamics simulations of magnesium aluminosilicate glass structure: High‐coordinated alumina and oxygen tricluster formation
Authors: Welch Rebecca S. , Salrin Tyler C. , Greiner Tyler , Bragatto Caio Barca , Mauro John C. 
Published: November 2023

AbstractPrevious research has shown a consistent discrepancy in the reported structure of alkaline earth aluminosilicate glasses using molecular dynamics (MD) simulations versus nuclear magnetic resonance (NMR) experiments. Past MD results have consistently shown less than 5% five‐coordinated Al units (Al[5]) in peraluminous glass compositions, but with high fractions of triple‐bonded oxygens (TBO, i.e., triclusters). Experimental results have shown a high fraction of Al[5] with no direct evidence for TBO. One of the main criticisms associated with high TBO content found in MD‐generated glass structures is the use of classical interatomic potentials. To investigate this issue, we analyze the formation of both TBO and Al[5] using three independently developed potentials with varying silica content and [Al2O3]/[MgO] ratios for the magnesium aluminosilicate (MAS) system. We specifically choose compositions with high ratios of alumina to magnesium oxide as this region is not as commonly explored. Results indicate that Al[5] charge compensates the Al network in metaluminous compositions (compositions with more Mg than Al) while both TBO and Al[5] are prevalent in peraluminous ranges (high Al content compositions) to charge balance Al units. From the literature, NMR experiments report MAS glasses with varying Al[5] fractions and show significant differences for the same reported compositions. When comparing MD results from this work, the fraction of calculated Al[5] is within the experimental variation found in the literature. This indicates that classical potentials can accurately capture alumina environments and that both Al[5] and TBO can coexist in relatively high fractions. From the consistency in our results, we conclude that TBOs are inherent to the aluminosilicate glass system and are not simulation artifacts.
CEO–board connections and the cost of equity capital: International evidence
Authors: Bhuyan Md Nazmul Hasan , Javakhadze David 
Published: November 2023

AbstractIn this article, we investigate the effect of chief executive officer (CEO)–board connections on the cost of equity capital in an international setting. We find that CEO–board connections have a significant negative effect on the cost of equity. Our results are robust to alternative variable measurements, model specifications, and potential endogeneity adjustments. Examining the channel, we show that social ties reduce information asymmetry issues. We further show that firm‐level operational complexities and investment intensity, as well as country‐level developmental attributes and culture, moderate the association between CEO–board connections and the cost of equity capital.
Baclofen and the risk of fall and fracture in older adults: A real‐world cohort study
Authors: Hwang Y. Joseph , Chang Alex R. , Brotman Daniel J. , Inker Lesley A. , Grams Morgan E. , Shin Jung‐Im 
Published: November 2023

AbstractBackgroundThe growth of oral muscle relaxant prescriptions among older adults in the United States is concerning due to the drugs' adverse sedative effects. Baclofen is a gamma‐aminobutyric acid agonist muscle relaxant that is associated with encephalopathy. We characterized the risk of fall and fracture associated with oral baclofen against other muscle relaxants (tizanidine or cyclobenzaprine) in older adults.MethodsWe designed a new‐user, active‐comparator study using tertiary health system data from Geisinger Health, Pennsylvania (January 2005 through December 2018). Older adults (aged ≥65 years) newly treated with baclofen, tizanidine, or cyclobenzaprine were included. Propensity score‐based inverse probability of treatment weighting (IPTW) was used to balance the treatment groups on 58 baseline characteristics. Fine–Gray competing risk regression was used to estimate the risk of fall and fracture.ResultsThe study cohort comprised of 2205 new baclofen users, 1103 new tizanidine users, and 9708 new cyclobenzaprine users. During a median follow‐up of 100 days, baclofen was associated with a higher risk of fall compared to tizanidine (IPTW incidence rate, 108.4 vs. 61.9 per 1000 person‐years; subdistribution hazard ratio [SHR], 1.68 [95% CI, 1.20–2.36]). The risk of fall associated with baclofen was comparable to cyclobenzaprine (SHR, 1.17 [95% CI, 0.93–1.47]) with a median follow‐up of 106 days. The risk of fracture was similar among patients treated with baclofen versus tizanidine (SHR, 0.85 [95% CI, 0.63–1.14]) or cyclobenzaprine (SHR, 0.85 [95% CI, 0.67–1.07]).ConclusionsThe risk of fall associated with baclofen was greater than tizanidine, but not compared to cyclobenzaprine in older adults. The risk of fracture was comparable among the older users of baclofen, tizanidine, and cyclobenzaprine. Our findings may inform risk‐benefit considerations in the increasingly common clinical encounters where oral muscle relaxants are prescribed.
Diverse signaling mechanisms and heterogeneity of astrocyte reactivity in Alzheimer's disease
Authors: Qin Hongwei , Zhou Lianna , Haque Faris T. , Martin‐Jimenez Cynthia , Trang Amy , Benveniste Etty N. , Wang Qin 
Published: November 2023

AbstractAlzheimer's disease (AD) affects various brain cell types, including astrocytes, which are the most abundant cell types in the central nervous system (CNS). Astrocytes not only provide homeostatic support to neurons but also actively regulate synaptic signaling and functions and become reactive in response to CNS insults through diverse signaling pathways including the JAK/STAT, NF‐κB, and GPCR‐elicited pathways. The advent of new technology for transcriptomic profiling at the single‐cell level has led to increasing recognition of the highly versatile nature of reactive astrocytes and the context‐dependent specificity of astrocyte reactivity. In AD, reactive astrocytes have long been observed in senile plaques and have recently been suggested to play a role in AD pathogenesis and progression. However, the precise contributions of reactive astrocytes to AD remain elusive, and targeting this complex cell population for AD treatment poses significant challenges. In this review, we summarize the current understanding of astrocyte reactivity and its role in AD, with a particular focus on the signaling pathways that promote astrocyte reactivity and the heterogeneity of reactive astrocytes. Furthermore, we explore potential implications for the development of therapeutics for AD. Our objective is to shed light on the complex involvement of astrocytes in AD and offer insights into potential therapeutic targets and strategies for treating and managing this devastating neurodegenerative disorder.
Subsidizing housing with deductions
Authors: Valentin Maxence 
Published: November 2023

AbstractMany governments subsidize owner‐occupied housing by allowing households to deduct housing expenses from their taxable incomes. While these deductions provide considerable financial benefits to homeowners, they also have significant downstream consequences. This article synthesizes a large body of literature that assesses these implications on various aspects of the housing market, including mortgage demand, interest rates, tenure decisions, homeownership rates, housing prices, and welfare. The findings in the literature collectively emphasize the distortive impact of these fiscal deductions on housing consumption and investment, with a growing consensus regarding the deductions' regressivity and negative effects on homeownership rates and welfare.
Concurrent invasions of European starlings in Australia and North America reveal population‐specific differentiation in shared genomic regions
Authors: Hofmeister Natalie R. , Stuart Katarina C. , Warren Wesley C. , Werner Scott J. , Bateson Melissa , Ball Gregory F. , Buchanan Katherine L. , Burt David W. , Cardilini Adam P. A. , Cassey Phillip , De Meyer Tim , George Julia , Meddle Simone L. , Rowland Hannah M. , Sherman Craig D. H. , Sherwin William B. , Vanden Berghe Wim , Rollins Lee Ann , Clayton David F. 
Published: November 2023

AbstractA species' success during the invasion of new areas hinges on an interplay between the demographic processes common to invasions and the specific ecological context of the novel environment. Evolutionary genetic studies of invasive species can investigate how genetic bottlenecks and ecological conditions shape genetic variation in invasions, and our study pairs two invasive populations that are hypothesized to be from the same source population to compare how each population evolved during and after introduction. Invasive European starlings (Sturnus vulgaris) established populations in both Australia and North America in the 19th century. Here, we compare whole‐genome sequences among native and independently introduced European starling populations to determine how demographic processes interact with rapid evolution to generate similar genetic patterns in these recent and replicated invasions. Demographic models indicate that both invasive populations experienced genetic bottlenecks as expected based on invasion history, and we find that specific genomic regions have differentiated even on this short evolutionary timescale. Despite genetic bottlenecks, we suggest that genetic drift alone cannot explain differentiation in at least two of these regions. The demographic boom intrinsic to many invasions as well as potential inversions may have led to high population‐specific differentiation, although the patterns of genetic variation are also consistent with the hypothesis that this infamous and highly mobile invader adapted to novel selection (e.g., extrinsic factors). We use targeted sampling of replicated invasions to identify and evaluate support for multiple, interacting evolutionary mechanisms that lead to differentiation during the invasion process.
The war in Ukraine and the ambivalent figure of ‘Babushka’: Intersectional nation‐building and the delegitimisation/legitimisation of war on YouTube
Authors: Lönnroth‐Olin Marja , Venäläinen Satu , Menard Rusten , Pauha Teemu , Jasinskaja‐Lahti Inga 
Published: November 2023

AbstractIn this article, we demonstrate how international social‐media discussions offer a platform for taking a stance on the war in Ukraine, redrawing national boundaries and legitimising their defence. We do so by analysing data that consist of comments triggered by a viral YouTube video depicting an encounter between an ageing civilian woman, labelled ‘Babushka Z’, and a Ukrainian soldier. Using a critical discursive psychological framework, we identify five interpretative repertoires: vulnerability, incapacity, national continuity, masculinised warriorship and righteousness. Our analysis illuminates how these repertoires draw on and reproduce intersecting categorisations based on gender, age and ethnic heritage. With the help of these categorisations, the repertoires build competing images of the actions of the figures in the video, which come to symbolise in various ways both patriotism and treason, heroism and cowardice. By aligning with competing historical‐national narratives, the commentors use these images to (de)legitimise the war and its actors.
Total pragmatic encroachment and belief–desire psychology
Authors: Langford Simon 
Published: November 2023

AbstractPragmatic encroachment in epistemology is the idea that whether one knows some proposition depends on whether one can rely on it practically. Total pragmatic encroachment affirms that practical considerations of this sort encroach not just on knowledge but on all interesting normative epistemic statuses a belief might have. Ichikawa, Jarvis, and Rubin (2012) have argued that this stronger thesis conflicts with mainstream belief‐desire psychology. Worse still, they argue that attempting to defend the thesis gets one caught in vicious circularities. The aim of this paper is to show that, if we are careful in how we understand the key idea of being sensitive to practical considerations, we can defend total pragmatic encroachment and avoid the circularities. In fact, depending on how it is understood, we can even square mainstream belief‐desire psychology with total pragmatic encroachment as well.
Longitudinal Wave Propagation in an Elastic Cylinder Embedded in a Viscoelastic Fluid
Authors: Aninou Mohamed , El Baroudi Adil , Le Pommellec Jean Yves 
Published: November 2023

Abstract
A novel analytical investigation of longitudinal wave propagation in an elastic cylinder embedded in a viscoelastic fluid is proposed. The Maxwell model is used to describe the viscoelastic fluid behavior. With appropriate boundary conditions, a complex dispersion equation of longitudinal waves has been established. The aim of this paper is to study the effect of the fluid rheological properties on the longitudinal wave characteristics (attenuation and velocity). It is shown that the attenuation is the sum of a viscous and nonviscous component. The viscosity-induced attenuation is predominant at low frequencies. On the other hand, the effect of the liquid amount and elastic cylinder radius on the attenuation and velocity are studied. A critical normalized liquid thickness is highlighted. Beyond this critical value, the influence of the outer boundary condition can be neglected. At last, among other interesting phenomena, it is highlighted that if the Deborah number increases, the attenuation decreases. This variation characterizes a stiffening of the viscoelastic medium. In addition, the obtained results show that the viscosity measurement should be performed at low frequencies using a small elastic cylinder radius. Accordingly, these investigations are novel and can be applied in geophysics, the food industry, medicine, nondestructive testing of materials, and the design and development of fluid sensors.
Complete genome sequence of bacteriophage MrAaronian isolated from an
Arthrobacter globiformis
culture
Authors: Haines Ian , Blakely Jessica , Branson Ashley , Estrada Diana , Fernandez Robles Rebeca , Fitzgerald Katelyn , Jeffers Shelby , Leung Timyee , Munoz Jasmine , Olivos Ashley , Ramirez Anayeli , Smith Caressa , Spere Justin , Tavarez Idaleth , Wood Isabella , Zavala Ethan , Arrighi Madison , Coronel-Galindo Angelica , Dennis Megan K. , Goppert Marlee , Edwards Dustin 
Published: November 2023

ABSTRACT

Arthrobacteriophage MrAaronian contains a 54,509 bp DNA genome with 87 predicted protein-coding genes. MrAaronian has siphovirus morphology and was collected from a flowerbed soil sample in Poughkeepsie, NY, and isolated on an
Arthrobacter globiformis
B-2979 culture. MrAaronian has > 99% nucleotide identity with cluster AW arthrobacteriophages Michelle, Stayer, Sloopyjoe, and StarLord.
Complete genome sequence of
Erythrobacteraceae
bacterium WH01K, a strain isolated from corals (
Acropora
sp.) in Taiwan
Authors: Hung Shih-Hsun Walter , Wu I-Chen , Huang Chieh-Chen , Kuo Chih-Horng 
Published: November 2023

ABSTRACT

Here, we report the isolation and genome sequence of a coral-associated
Erythrobacteraceae
bacterium, strain WH01K. The complete assembly consists of one 2,745,896 bp circular chromosome and one 172,502 bp circular plasmid.