bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timing the clinical onset of epileptic spasms in infantile epileptic spasms syndrome: A tertiary health center's experience
Authors: Hadjinicolaou Aristides , Briscoe Abath Christina , Singh Avantika , Donatelli Stephanie , Salussolia Catherine L. , Cohen Alexander Li , He Jie , Gupta Nishtha , Merchant Sabrina , Zhang Bo , Olson Heather , Yuskaitis Christopher J. , Libenson Mark H. , Harini Chellamani 
Published: February 2024

AbstractObjectiveLead time to treatment (clinical onset of epileptic spasms [ES] to initiation of appropriate treatment) is known to predict outcomes in infantile epileptic spasms syndrome (IESS). Timing the clinical onset of ES is crucial to establish lead time. We investigated how often ES onset could be established to the nearest week. We aimed to (1) ascertain the exact date or estimate the nearest week of ES onset and (2) compare clinical/demographic factors between patients where date of ES onset was determined or estimated to the nearest week and patients whose date of ES onset could not be estimated to the nearest week. Reasons for difficulties in estimating date of ES onset were explored.MethodsRetrospective chart review of new onset IESS patients (January 2019–May 2022) extracted the date or week of the clinical onset of ES. Predictors of difficulty in date of ES onset estimation to the nearest week were examined by regression analysis. Sources contributing to difficulties determining date of ES onset were assessed after grouping into categories (provider‐, caregiver‐, disease‐related).ResultsAmong 100 patients, date of ES onset was estimated to the nearest week in 47%. On univariable analysis, age at diagnosis (p = .021), development delay (p = .007), developmental regression/stagnation (p = .021), ES intermixed with other seizures (p = .011), and nonclustered ES at onset (p = .005) were associated with difficulties estimating date of ES onset. On multivariable analysis, failure to establish date of ES onset was related to ES intermixed with other seizures (p = .004) and nonclustered ES at onset (p = .003). Sources contributing to difficulties determining date of ES onset included disease‐related factors (ES characteristics, challenges interpreting electroencephalograms) and provider/caregiver‐related factors (delayed diagnosis).SignificanceDifficulties with estimation of lead time (due to difficulties timing ES onset) can impact clinical care (prognostication), as even small increments in lead time duration can have adverse developmental consequences.
Hatchery supplementation provides a demographic boost but alters age composition of sockeye salmon in Auke Lake, Southeast Alaska
Authors: McPhee Megan V. , Barry Patrick D. , Habicht Chris , Vulstek Scott C. , Russell Joshua R. , Smoker William W. , Joyce John E. , Gharrett Anthony J. 
Published: February 2024

AbstractEvaluating salmon hatchery supplementation programs requires assessing not only program objectives but identifying potential risks to wild populations as well. Such evaluations can be hampered by difficulty in distinguishing between hatchery‐ and wild‐born returning adults. Here, we conducted 3 years (2011–2013) of experimental hatchery supplementation of sockeye salmon in Auke Lake, Juneau, Alaska where a permanent weir allows sampling and genotyping of every returning adult (2008–2019). We identified both hatchery‐ and wild‐born returning adults with parentage assignment, quantified the productivity (adult offspring/spawner) of hatchery spawners relative to that of wild spawners, and compared run timing, age, and size at age between hatchery‐ and wild‐born adults. Hatchery‐spawning females produced from approximately six to 50 times more returning adults than did naturally spawning females. Supplementation had no discernable effect on run timing and limited consequences for size at age, but we observed a distinct shift to younger age at maturity in the hatchery‐born individuals in all three brood years. The shift appeared to be driven by hatchery‐born fish being more likely to emigrate after one, rather than two, years in the lake but the cause is unknown. In cases when spawning or incubation habitat is limiting sockeye salmon production, hatchery supplementation can be effective for enhancing the number of returning adult fish but not without the risk of phenotypic change in the recipient population, which can be an undesired outcome of hatchery supplementation. This study adds to a growing body of evidence suggesting that phenotypic change within a single generation of captive spawning might be widespread in salmon hatchery programs.
Automatic early detection of induced colic in horses using accelerometer devices
Authors: Eerdekens Anniek , Papas Marion , Damiaans Bert , Martens Luc , Govaere Jan , Joseph Wout , Deruyck Margot 
Published: February 2024

AbstractBackgroundTo seek appropriate veterinary attention for horses with colic, owners must recognise early signs. Direct observation of horse behaviour has several drawbacks: it is time‐consuming, hard to see subtle and common behavioural signs, and is based on intuition and subjective decisions. Due to recent advances in wearables and artificial intelligence, it may be possible to develop diagnostic software that can automatically detect colic signs.ObjectivesTo develop a software algorithm to aid in the detection of colic signs and levels of pain.Study designIn vivo experiments.MethodsTransient colic was induced in eight experimental mares with luteolytic doses of prostaglandin. Veterinarians observed the horses before and throughout the interventions and assigned pain scores which were used to separate colic episodes into none (pain score ≤5), level 1 (pain score 6–10) or level 2 (pain score ≥11). Accelerometric data and videos were collected throughout the experiments and using accelerometric data, the horse's behaviour was classified into normal and 10 pain‐related behaviours and an activity index was calculated. Models were designed that utilised behaviour and activity index characteristics both detecting the presence of colic and assessing its severity. To determine the accuracy of the model, the ground truth, that is the veterinarians' observation of colic signs and assessment of pain level, was compared with the automatic detection system.ResultsThe cross‐validation analysis demonstrated an accuracy of 91.2% for detecting colic and an accuracy of 93.8% in differentiating between level 1 colic and level 2 colic. The model was able to accurately classify 10 pain‐related behaviours and distinguish them from normal behaviour with a high accuracy.Main limitationsWe included a limited number of horses with severe pain related behaviours in the dataset. This constraint affects the accuracy of categorising colic severity rather than limiting the algorithms' capacity to identify early colic signs.ConclusionsOur system for early detection of colic in horses is unique and innovative, and it can distinguish between colic of varying severity.
Stock discrimination of two European squids (Illex coindetii, Loligo forbesii) by statolith shape analysis
Authors: Bobowski Bianca T. C. , Power Anne Marie , Burns Finlay , Carbonara Pierluigi , Cuccu Danila , Donnaloia Marilena , Follesa Maria Cristina , Moreno Ana , Sokolova Inna M. , Valls Maria , Oesterwind Daniel 
Published: February 2024

AbstractWe evaluated the feasibility of classifying ommastrephid and loliginid squid species by statolith shape analysis into fisheries management units or stocks. Statoliths of Illex coindetii (Verany, 1839) and Loligo forbesii (Steenstrup, 1856) were studied from multiple areas of the North East Atlantic and Northern Mediterranean Sea during 2021–2022. I. coindetii and L. forbesii individuals were categorized into multiple stocks across the areas studied. Stocks migrating between fishing areas as well as multiple stocks in the same area, as identified for L. forbesii in this study, need to be considered for sustainable fisheries management.
Ocean climate and hydrodynamics drive decadal shifts in Northeast Atlantic dinoflagellates
Authors: Kléparski Loïck , Beaugrand Grégory , Ostle Clare , Edwards Martin , Skogen Morten D. , Djeghri Nicolas , Hátún Hjálmar 
Published: February 2024

AbstractThe abundance of large marine dinoflagellates has declined in the North Sea since 1958. Although hypotheses have been proposed to explain this diminution (increasing temperature and wind), the mechanisms behind this pattern have thus far remained elusive. In this article, we study the long‐term changes in dinoflagellate biomass and biodiversity in relation to hydro‐climatic conditions and circulation within the North Atlantic. Our results show that the decline in biomass has paralleled an increase in biodiversity caused by a temperature‐induced northward movement of subtropical taxa along the European shelf‐edge, and facilitated by changes in oceanic circulation (subpolar gyre contraction). However, major changes in North Atlantic hydrodynamics in the 2010s (subpolar gyre expansion and low‐salinity anomaly) stopped this movement, which triggered a biodiversity collapse in the North Sea. Further, North Sea dinoflagellate biomass remained low because of warming. Our results, therefore, reveal that regional climate warming and changes in oceanic circulation strongly influenced shifts in dinoflagellate biomass and biodiversity.
Spectral asynchrony as a measure of ecosystem response diversity
Authors: Mazzochini Guilherme G. , Rowland Lucy , Lira‐Martins Demétrius , Barros Fernanda de V. , Flores Bernardo M. , Hirota Marina , Pennington R. Toby , Oliveira Rafael S. 
Published: February 2024

AbstractSpecies diversity is crucial for promoting ecosystem resilience and stability. Species diversity promotes complementarity in resource use, resulting in a wider range of responses to adverse conditions. This enables populations of different species to fluctuate asynchronously, maintaining ecosystem functioning during extreme climatic events. However, incorporating such mechanisms into conservation decisions and ecosystem modelling requires scalable metrics that represent species diversity, which is currently lacking. To address this, we introduce spectral asynchrony, a metric that captures the spatial heterogeneity of species’ functional responses occurring in distinct pixels. Here, we use remote sensing datasets to investigate the relationship between spectral asynchrony and productivity responses of seasonally dry tropical forests (SDTF) to climatic fluctuations. Our findings reveal that spectral asynchrony is associated with increased resistance and recovery of SDTF productivity in following extreme drought years, as well as greater productivity stability over two decades. Furthermore, higher spectral asynchrony was associated with relatively wetter regions, suggesting that increasing aridity across SDTF could potentially reduce landscape heterogeneity and limit ecosystem resilience to increasing droughts in the future. Spectral asynchrony provides an easily measurable and monitorable metric for assessing ecosystem responses to global changes, reflecting and scaling‐up the effects of species diversity at the local level.
The value‐based healthcare approach to haemophilia: Development of outcome measures for the evaluation of care of people with haemophilia
Authors: Cortesi Paolo Angelo , Fornari Carla , Conti Sara , Pollio Berardino , Boccalandro Elena , Buzzi Andrea , Carulli Christian , Coppola Antonio , De Cristofaro Raimondo , Di Minno Matteo Nicola Dario , Dolan Gerard , Ferri Grazzi Enrico , Fornari Arianna , Gualtierotti Roberta , Hermans Cedric , Jiménez‐Juste Victor , Kenet Gili , Lupi Angelo , Martinoli Carlo , Mansueto Maria Francesca , Nicolò Gabriella , Tagliaferri Annarita , Gringeri Alessandro , Molinari Angelo Claudio , Mantovani Lorenzo Giovanni , Castaman Giancarlo ,   the V.B.H. project group
Published: February 2024

AbstractIntroductionConsidering the advances in haemophilia management and treatment observed in the last decades, a new set of value‐based outcome indicators is needed to assess the quality of care and the impact of these medical innovations.AimThe Value‐Based Healthcare in Haemophilia project aimed to define a set of clinical outcome indicators (COIs) and patient‐reported outcome indicators (PROIs) to assess quality of care in haemophilia in high‐income countries with a value‐based approach to inform and guide the decision‐making process.MethodsA Value‐based healthcare approach based on the available literature, current guidelines and the involvement of a multidisciplinary group of experts was applied to generate a set of indicators to assess the quality of care of haemophilia.ResultsA final list of three COIs and five PROIs was created and validated. The identified COIs focus on two domains: musculoskeletal health and function, and safety. The identified PROIs cover five domains: bleeding frequency, pain, mobility and physical activities, Health‐Related Quality of Life and satisfaction. Finally, two composite outcomes, one based on COIs, and one based on PROIs, were proposed as synthetic outcome indicators of quality of care.ConclusionThe presented standard set of health outcome indicators provides the basis for harmonised longitudinal and cross‐sectional monitoring and comparison. The implementation of this value‐based approach would enable a more robust assessment of quality of care in haemophilia, within a framework of continuous treatment improvements with potential added value for patients. Moreover, proposed COIs and PROIs should be reviewed and updated routinely.
Low‐dose or high‐dose amoxicillin in vonoprazan‐based dual therapy for Helicobacter pylori eradication? A systematic review and meta‐analysis
Authors: Ju Kun‐Ping , Kong Qing‐Zhou , Li Yue‐Yue , Li Yan‐Qing 
Published: February 2024

AbstractBackgroundThe amoxicillin dose used in dual therapy to eradicate Helicobacter pylori varies across studies and the optimal amoxicillin dose for vonoprazan‐based dual therapies remains unclear. We aimed to investigate the efficacy and safety of low‐ and high‐dose amoxicillin in vonoprazan–amoxicillin dual therapy.Materials and MethodsA comprehensive systematic review was conducted by searching databases from inception to October 2023. All trials that evaluated the effectiveness and safety of vonoprazan–amoxicillin dual therapy for eradicating H. pylori were included. Pooled eradication rate, incidence of adverse events, relative risks, and 95% confidence intervals are presented.ResultsEighteen studies with 12 low‐dose amoxicillin (VLA) and 13 high‐dose amoxicillin (VHA) arms were included. The pooled eradication rates were 82.4% and 86.8% for VLA therapy, and 86.0% and 90.9% for VHA therapy by the intention‐to‐treat and per‐protocol analyses, respectively. In the subgroup analysis stratified by duration, the eradication rates achieved in 7 days, 10 days, and 14 days treatments with VLA and VHA dual therapies were 80.8%, 84.2%, 83.1%, and 67.3%, 88.8%, 87.5%, respectively. In the four randomized controlled trials that directly compared VLA and VHA dual therapies, the efficacy was not statistically different in the intention‐to‐treat (76.9% vs 81.4%, p = 0.337) and per‐protocol (81.6% vs 84.0%, p = 0.166) analyses. Additionally, the incidence of adverse events (p = 0.965) and compliance (p = 0.994) were similar in both groups.ConclusionVLA therapy demonstrated comparable efficacy and safety to VHA therapy, along with regional differences. An appropriately extended treatment duration may be critical for therapeutic optimization of vonoprazan–amoxicillin treatment.
Studying the role of Bombyx mori molybdenum cofactor sulfurase in Bombyx mori nucleopolyhedrovirus infection
Authors: Lv Jun‐li , Lai Wen‐qing , Gong Yu‐quan , Zheng Kai‐yi , Zhang Xiao‐ying , Wang Xue‐yang , Dai Li‐shang , Li Mu‐wang 
Published: February 2024

AbstractMolybdenum cofactor sulfurase (MoCoS) is a key gene involved in the uric acid metabolic pathway that activates xanthine dehydrogenase to synthesise uric acid. Uric acid is harmful to mammals but plays crucial roles in insects, one of which is the immune responses. However, the function of Bombyx mori MoCoS in response to BmNPV remains unclear. In this study, BmMoCoS was found to be relatively highly expressed in embryonic development, gonads and the Malpighian tubules. In addition, the expression levels of BmMoCoS were significantly upregulated in three silkworm strains with different levels of resistance after virus infection, suggesting a close link between them. Furthermore, RNAi and overexpression studies showed that BmMoCoS was involved in resistance to BmNPV infection, and its antivirus effects were found to be related to the regulation of uric acid metabolism, which was uncovered by inosine‐ and febuxostat‐coupled RNAi and overexpression. Finally, the BmMoCoS‐mediated uric acid pathway was preliminarily confirmed to be a potential target to protect silkworms from BmNPV infection. Overall, this study provides new evidence for elucidating the molecular mechanism of silkworms in response to BmNPV infection and new strategies for the prevention of viral infections in sericulture.
A person‐centred view of citizen participation in civic crowdfunding platforms: A mixed‐methods study of civic backers
Authors: Soltani Delgosha Mohammad , Hajiheydari Nastaran , Olya Hossein 
Published: February 2024

AbstractCrowdfunding platforms have emerged as a promising contemporary means for mobilising collective civic actions to address local or social issues, improve community cohesion and develop the public good. This empirical study taps into the understudied civic crowdfunding platforms (CCP) developed to facilitate such actions, proposing, supporting and funding public‐interest projects through crowdsourcing and microfinancing. Previous studies have shown that individuals' characteristics affect their level of civic engagement with social issues. Considering the diversity of contributor motivations, we aim to shed light on the dynamics of emergent subpopulations of citizens who participate in CCPs. To this end, we use a sequential mixed‐methods approach to integrate our fuzzy set Qualitative Comparative Analysis (fsQCA) findings with the results of an in‐depth qualitative study, to gain rich and robust inferences and meta‐inferences. In Study 1 (n = 316), we used fsQCA to explore five distinctive configural profiles that display the heterogeneity of civic backers' motivations, including civic champions, prosocial advocates, normative supporters, reward seekers and regret‐averse contributors. In Study 2, we corroborated and complemented our fsQCA inferences through an extreme‐case study and identified four boundary conditions. Taken together, our inferences and meta‐inferences address the heterogeneity of motivations for participating in CCPs, by understanding and theorising about diverse profiles of citizen backers. Finally, we offer practical implications for successful civic crowdfunding initiatives.
Everyday forms of resistance in Istanbul day labourer areas: Comparative experiences of immigrant and local workers
Authors: Çölgeçen Ahmet Ertan 
Published: February 2024

AbstractPrecarity extends beyond economic and material conditions to shape people's identity, belonging and subjectivity. As a process, precarity has made instability a virtue by lifting the smokescreen that previously hid relations of production. Its institutional crystallization becomes concrete in state apparatuses and social relations. It targets both subjectivity and the life of the population as a whole. Therefore, it participates in everyday life as a hegemonic form of rule. This study focuses on the experiences of precarity, the production of subjectivity and the areas of conflict of local and migrant labourers in day‐labour hiring sites in Istanbul. Day‐labour sites are areas where precarity is normalized. In contrast, day labourers produce their own areas of autonomy in day‐labour sites. The loyalties of migrant and non‐migrant labourers to each other differ in day‐labour sites. Due to the production of certain oppositions through identities in labour areas, the relations of domination have certain invisibility. Nevertheless, the practices of day labourers in organizing their mutual relations intersect in these sites.
The relevance of the contribution of psychoneuroendocrinoimmunology and psychology of reasoning and decision making to nursing science: A discursive paper
Authors: Milani Alessandra , Saiani Luisa , Misurelli Eliana , Lacapra Silvana , Pravettoni Gabriella , Magon Giorgio , Mazzocco Ketti 
Published: February 2024

AbstractAimPatients' death or adverse events appear to be associated with poor healthcare decision‐making. This might be due to an inability to have an adequate representation of the problem or of the connections among problem‐related elements. Changing how a problem is formulated can reduce biases in clinical reasoning. The purpose of this article is to explore the possible contributions of psychoneuroendocrinoimmunology (PNEI) and psychology of reasoning and decision‐making (PRDM) to support a new nursing theoretical frame.DesignDiscursive paper.MethodThis article discusses the main assumptions about nursing and nurses' ability to face patient's problems, suggesting a new approach that integrates knowledge from PNEI and PRDM. While PNEI explains the complexity of systems, highlighting the importance of systems connections in affecting health, PRDM underlines the importance of the informative context in creating a mental representation of the problem. Furthermore, PRDM suggests the need to pay attention to information that is not immediately explicit and its connections.ConclusionNursing recognizes the patient–nurse relationship as the axiom that governs care. The integration of PNEI and PRDM in nursing theoretics allows the expansion of the axiom by providing essential elements to read a new type of relationship: the relationship among information. PNEI explains the relationships between biological systems and the psyche and between the whole individual and the environment; PRDM provides tools for the nurse's analytical thinking system to correctly process information and its connections.Impact on Nursing PracticeA theoretical renewal is mandatory to improve nursing reasoning and nursing priority identification. Integrating PNEI and PRDM into nursing theoretics will modify the way professionals approach patients, reducing cognitive biases and medical errors.No Patient or Public ContributionThere was no patient or public involvement in the design or writing of this discursive article.