bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haloperidol, but not clozapine, produces dramatic catalepsy in Δ9‐THC‐treated rats: possible clinical implications
Authors: Marchese Giorgio , Casti Paola , Ruiu Stefania , Saba PierLuigi , Sanna Angela , Casu GianLuca , Pani Luca 
Published: October 2003

The effect on rat catalepsy induced by Δ9‐tetrahydrocannabinol (Δ9‐THC) in association with haloperidol (HP) or clozapine (CLOZ) administration was investigated.
Δ9‐THC dose‐dependently increased HP (0.05–1 mg kg−1, s.c.)‐induced rat catalepsy, while no catalepsy was observed after CLOZ (1–20 mg kg−1, s.c.) or Δ9‐THC+CLOZ administration.
The CB1 antagonist SR141716A (0.5–5 mg kg−1, i.p.) reversed the increase mediated by Δ9‐THC on HP‐induced catalepsy.
The D2 agonist quinpirole completely reversed the catalepsy induced by both HP and HP+Δ9‐THC; however, higher doses of quinpirole were needed in the presence of Δ9‐THC.
The M1 antagonist scopolamine and α2 antagonist yohimbine were able to reduce the catalepsy induced by HP and HP+Δ9‐THC in a similar manner.
CLOZ and the 5‐HT2A/2C antagonists ritanserin, RS102221 and SB242084 were more effective in antagonizing HP than HP+Δ9‐THC‐induced catalepsy.
HP and CLOZ failed to inhibit in vitro [3H]CP‐55,940 binding, while Δ9‐THC and SR141716A did not show an appreciable affinity for the D2 receptor.
It was suggested that the different effects on rat catalepsy induced by Δ9‐THC following HP or CLOZ administration may depend on the receptor‐binding profiles of the two antipsychotics.
The preferential use of CLOZ rather than HP in the treatment of psychotic symptoms in cannabis abusers was discussed.

British Journal of Pharmacology (2003) 140, 520–526. doi:10.1038/sj.bjp.0705478
Impact of the health and living conditions of migrant and non-migrant Senegalese adolescent girls on their nutritional status and growth
Authors: Garnier Denis , Simondon Kirsten B , Hoarau Thierry , Benefice Eric 
Published: October 2003

AbstractObjective:To describe the living conditions of Senegalese adolescent girls according to their migration status, and to define the main socio-economic and biological determinants of their nutritional and growth status.Design:Health and living conditions, sexual maturation, and nutritional and growth status of adolescent girls were determined within the framework of a longitudinal study on growth.Settings:The capital city of Senegal (Dakar) and a rural community (Niakhar), 120 km south-east of Dakar.Subjects:Three hundred and thirty-one girls, 14.5–16.6 years of age, were recruited from the same villages. Thirty-six per cent of the sample remained in the villages to attend school and/or to help with household subsistence tasks (non-migrants). The remaining (64%) migrated to cities to work as maids (migrants) and lived in two different socio-economic environments: at the home of a guardian during the night and in the house of the employer during the daytime.Results:Family rural environment and guardian and employer urban environments were socio-economically different (P < 0.001). Living conditions in urban areas were better than in rural areas and the employer's environment was socio-economically more favourable. Migrants had more advanced sexual maturation and higher body mass index (BMI), fat mass index (FMI) and mid-upper arm circumference than non-migrants. However, migrants were smaller than non-migrants. BMI, FMI and weight-for-age were related to socio-economic levels and duration of migration. Schooling was positively related to height and negatively related to BMI.Conclusions:Migrants enjoyed better living conditions than non-migrants. This could be partly due to the better socio-economic environment of the employer. It was associated with earlier puberty and better nutritional status, but not with a better growth.
A Belgian study on the reliability and relative validity of the Health Behaviour in School-Aged Children food-frequency questionnaire
Authors: Vereecken Carine A , Maes Lea 
Published: October 2003

AbstractObjective:In the Health Behaviour in School-Aged Children (HBSC) survey, the frequency of consumption of a limited number of food items – focusing on fibre, calcium and less healthy items – is queried using a 15-item food-frequency questionnaire (FFQ). The present study was conducted to assess the reliability and relative validity of the HBSC FFQ among school pupils in Belgium.Design and subjects:To assess the reliability of the FFQ, 207 pupils aged 11–12 years and 560 pupils aged 13–14 years completed the questionnaire twice, with a test–retest interval of 6 to 15 days. To assess the relative validity of the FFQ, in a first study data were collected as part of the Flemish HBSC 2000 survey: 7072 pupils (11–18 years) completed the FFQ and a 24-hour food behaviour checklist (FBC). In a second study, 101 pupils (11–12 years) completed the FFQ and a 7-day food diary (FD).Results:Reliability – weighted kappa values between test and retest ranged from 0.43 to 0.70, percentage agreement from 37 to 87%, and Spearman correlations from 0.52 to 0.82. Relative validity – comparison of the FBC with the percentage of respondents who should have consumed the food items on a random day, computed from the FFQ, showed good agreement between the FFQ and the FBC for most items. Only for cereals, diet soft drinks and other milk products were considerably higher food frequencies than expected found from the FBC. Comparison of the FFQ with the FD showed overestimation for all but three food items (cheese, soft drinks and chips). Spearman correlations ranged between 0.10 for crisps and 0.65 for semi-skimmed milk.Conclusion:The HBSC FFQ is a reliable questionnaire that can be used for ranking subjects for most food items, although one must consider the overestimation when the FFQ is used for estimating prevalences.
A conceptual framework for intelligence-based public health nutrition workforce development
Authors: Hughes Roger 
Published: October 2003

AbstractObjective:This paper describes a conceptual framework and associated intelligence requirements for problem-based workforce development for public health nutrition.Methods:A conceptual framework for public health nutrition workforce development was constructed based on a review of the literature and consideration of the intelligence needs to inform workforce development planning.Results:A cyclical conceptual framework including five intelligence-linked components including public health nutrition problems and priorities, solutions and best buys, work needed, capacity to do the work and workforce development needs. This framework applied to the Australian situation illustrates its applications in workforce development research and planning. Although the existing availability of workforce development intelligence in each of these components varies, the framework does provide a systematic approach for workforce development research and planning directly related to public health nutrition problem resolution.Conclusions:This framework highlights deficiencies in the existing public health nutrition workforce development intelligence and the need for further research to inform workforce development strategy planning.
A comparison between the National Food Survey and the Family Expenditure Survey food expenditure data
Authors: Paterakis Sophia E , Nelson Michael 
Published: October 2003

AbstractObjective:Household budget surveys (HBSs) have been used to assess nutritional information for epidemiological purposes. The agreement between this information and other comparable data needs to be examined. The aim of this project was to compare household food expenditure data between two British HBSs: the National Food Survey (NFS) and the Family Expenditure Survey (FES).Design:Household food expenditure data were compared between the NFS and the FES for the years from 1982 to 1993. Differences in expenditure were assessed by year, by household composition, by income group and by region; for trends across time for all households and for regional, household composition and income group variations.Setting:Great Britain.Subjects:Approximately 88 000 NFS households and 85 000 FES households surveyed between 1982 and 1993 were used in this analysis.Results:Marked differences between the food expenditure data provided by the two surveys were observed. Furthermore, differences in time trends were substantial, which can lead to different conclusions regarding changes in consumption patterns.Conclusions:There is no obvious reason for the differences in household food expenditure between the NFS and the FES. Methodological differences between the two surveys cannot provide a full explanation for these discrepancies. The NFS and FES are now merged into a single survey (the Expenditure and Food Survey). If HBSs are to be used for epidemiological purposes their validity needs to be established.
Evaluation of the impact of an iodine supplementation programme on severely iodine-deficient schoolchildren with hypothyroidism
Authors: Salarkia Nahid , Hedayati Mehdi , Mirmiran Parvin , Kimiagar Masood , Azizi Fereidoun 
Published: October 2003

AbstractBackground:Northern rural areas of Tehran have been shown to have severe iodine deficiency in our previous studies. In 1989 the inhabitants of these villages received an injection of iodised oil, followed by iodised salt distribution in 1993. The aim of the present study was to evaluate the effect of the iodine supplementation on iodine-deficient schoolchildren with hypothyroidism in these villages.Methods:In total, 571 students aged 6–14 years were studied. Goitre was graded according to the World Health Organization classification. Serum concentrations of thyroid hormones (thyroxine (T4) and triiodothyronine (T3)) and thyroid-stimulating hormone (TSH) were determined using commercial kits, and urinary iodine was measured using a digestion method. The results were compared with data from our previous study in 1989.Results:Total goitre rate decreased by 42% in 1999 compared with that in 1989. A significant decrease in Grade 2 goitre concomitant with an increase in Grade 1 goitre was seen (P < 0.001). Values of the variables studied before (1989) and 10 years after iodine supplementation (1999) were: median urinary iodine excretion, 2.0 vs. 19.0 μg dl−1 (P < 0.001); T4, 6.5 ± 2.0 vs. 8.4 ± 1.6 μg dl−1 (P < 0.001); T3, 177 ± 38.0 vs. 145 ± 29.0 ng dl−1 (P < 0.001); TSH, 10.8 ± 15.1 vs. 1.8 ± 0.8 μU ml−1 (P < 0.001). No correlation was found between thyroid hormones and TSH on the one hand, and goitre and urinary iodine, on the other. Serum T4, T3 and TSH concentrations were within normal ranges in all schoolchildren in 1999.Conclusion:This study showed that euthyroidism induced by administration of iodised oil in iodine-deficient schoolchildren with hypothyroidism is sustained following the consumption of iodised salt.
Definitions for public health nutrition: a developing consensus
Authors: Hughes Roger 
Published: October 2003

AbstractObjectives:To assess the level of agreement amongst a panel of public health nutrition leaders regarding the key descriptors used to define the field of public health nutrition.Design:Cross-sectional survey requiring quantitative and qualitative responses representing the first round of a consensus development Delphi technique.Setting:International.Subjects:Expert panel of 24 public health nutrition leaders from nine countries in the European Union, the USA and Australia.Results:All but one of the panel agreed it was important to have a consensus definition for public health nutrition to describe the field consistently. Opinion about the length and complexity of this definition tended to vary depending on the intended use of the definition. The large majority (18/24) supported the inclusion of specific reference to physical activity in a definition of public health nutrition, although there was not consensus (>83% agreement as criterion) on this point. Consensus descriptors regarded as important in a definition of public health nutrition included: population-based, focus on health promotion, food and nutrition systems focus, wellness maintenance, primary prevention, applies public health principles, education, environmental and political descriptors. Treatment as a descriptor was rated as unimportant by a majority (14/24) of panellists, delineating public health nutrition from clinical practice.Conclusions:There is strong international agreement amongst public health nutrition leaders in Europe, the USA and Australia about a range of descriptors that can be used to define public health nutrition. The limitations of using word-for-word definitions between and within countries may be overcome by explicit use of the consensus descriptors identified in this process.
The relationship between low income and household food expenditure patterns in Canada
Authors: Kirkpatrick Sharon , Tarasuk Valerie 
Published: October 2003

AbstractObjectives:To compare food expenditure patterns between low-income households and higher- income households in the Canadian population, and to examine the relationship between food expenditure patterns and the presence or absence of housing payments among low-income households.Design:Secondary data analysis of the 1996 Family Food Expenditure Survey conducted by Statistics Canada.Setting:Sociodemographic data and 1-week food expenditure data for 9793 households were analysed.Subjects:Data were collected from a nationally representative sample drawn through stratified multistage sampling. Low-income households were identified using Statistics Canada's Low Income Measures.Results:Total food expenditures, expenditures at stores and expenditures in restaurants were lower among low-income households compared with other households. Despite allocating a slightly greater proportion of their food dollars to milk products, low-income households purchased significantly fewer servings of these foods. They also purchased fewer servings of fruits and vegetables than did higher-income households. The effect of low income on milk product purchases persisted when the sample was stratified by education and expenditure patterns were examined in relation to income within strata. Among low-income households, the purchase of milk products and meat and alternatives was significantly lower for households that had to pay rents or mortgages than for those without housing payments.Conclusions:Our findings indicate that, among Canadian households, access to milk products and fruits and vegetables may be constrained in the context of low incomes. This study highlights the need for greater attention to the affordability of nutritious foods for low-income groups.
The Transport of Prolamine RNAs to Prolamine Protein Bodies in Living Rice Endosperm Cells[W]
Authors: Hamada Shigeki , Ishiyama Keiki , Choi Sang-Bong , Wang Changlin , Singh Salvinder , Kawai Naoko , Franceschi Vincent R. , Okita Thomas W. 
Published: October 2003

AbstractRNAs that code for the major rice storage proteins are localized to specific subdomains of the cortical endoplasmic reticulum (ER) in developing endosperm. Prolamine RNAs are localized to the ER and delimit the prolamine intracisternal inclusion granules (PB-ER), whereas glutelin RNAs are targeted to the cisternal ER. To study the transport of prolamine RNAs to the surface of the prolamine protein bodies in living endosperm cells, we adapted a two-gene system consisting of green fluorescent protein (GFP) fused to the viral RNA binding protein MS2 and a hybrid prolamine RNA containing tandem MS2 RNA binding sites. Using laser scanning confocal microscopy, we show that the GFP-labeled prolamine RNAs are transported as particles that move at an average speed of 0.3 to 0.4 μm/s. These prolamine RNA transport particles generally move unidirectionally in a stop-and-go manner, although nonlinear bidirectional, restricted, and nearly random movement patterns also were observed. Transport is dependent on intact microfilaments, because particle movement is inhibited rapidly by the actin filament–disrupting drugs cytochalasin D and latrunculin B. Direct evidence was obtained that these prolamine RNA-containing particles are transported to the prolamine protein bodies. The significance of these results with regard to protein synthesis in plants is discussed.
Rapid Induction of Distinct Stress Responses after the Release of Singlet Oxygen in Arabidopsis[W]
Authors: op den Camp Roel G. L. , Przybyla Dominika , Ochsenbein Christian , Laloi Christophe , Kim Chanhong , Danon Antoine , Wagner Daniela , Hideg Éva , Göbel Cornelia , Feussner Ivo , Nater Mena , Apel Klaus 
Published: October 2003

AbstractThe conditional fluorescent (flu) mutant of Arabidopsis accumulates the photosensitizer protochlorophyllide in the dark. After a dark-to-light shift, the generation of singlet oxygen, a nonradical reactive oxygen species, starts within the first minute of illumination and was shown to be confined to plastids. Immediately after the shift, plants stopped growing and developed necrotic lesions. These early stress responses of the flu mutant do not seem to result merely from physicochemical damage. Peroxidation of chloroplast membrane lipids in these plants started rapidly and led to the transient and selective accumulation of a stereospecific and regiospecific isomer of hydroxyoctadecatrieonic acid, free (13S)-HOTE, that could be attributed almost exclusively to the enzymatic oxidation of linolenic acid. Within the first 15 min of reillumination, distinct sets of genes were activated that were different from those induced by superoxide/hydrogen peroxide. Collectively, these results demonstrate that singlet oxygen does not act primarily as a toxin but rather as a signal that activates several stress-response pathways. Its biological activity in Arabidopsis exhibits a high degree of specificity that seems to be derived from the chemical identity of this reactive oxygen species and/or the intracellular location at which it is generated.
Factorial Correlators and Split-Bin Correlation Functions in p-Nucleus Interactions at 800 GeV
Authors: Dheer Simi , Das Geetanjali , Shivpuri R. K. , Soni S. K. 
Published: October 2003

We present the first results on correlations in multiparticle production in p-nucleus interactions at 800 GeV using scaled factorial correlators and split-bin correlation functions. The behaviors of factorial correlators as a function of bin-bin distance in pseudorapidity as well as bin width is consistent with the random cascading picture of hadronization. From the analysis of the split-bin correlation functions as a function of bin-width, it is found that the two-particle dynamical correlations are due to resonance-like production mechanism.
Chargino Production in Different Supergravity Models and the Effect of the Tadpoles
Authors: Díaz Marco Aurelio 
Published: October 2003

If the lightest chargino is discovered at LEP2, the measurement of its mass and cross-section together with the mass of the lightest neutralino, enables the determination of the parameters that define the theory and the entire supersymmetric and Higgs spectrum. Within this context, we: (i) study the effect of the one-loop tadpoles in the minimization condition of the Higgs potential, by comparing the RGE-improved Higgs potential approximation with the calculation of the minimum including the effect of the one-loop tadpoles, and (ii) compare the prediction of two different supergravity models, namely, the model based on B=2m0 and motivated by the solution of the μ-problem, and the minimal supergravity model, based on A=B-m0.
Low x Behavior of the Isovector Nucleon Polarized Structure Function and the Bjorken Sum Rule
Authors: Buccella Franco , Pisanti Ofelia , Santorelli Pietro 
Published: October 2003

The combination [Formula: see text] is derived from SLAC data on polarized proton and deuteron targets, evaluated at Q2=10 GeV 2, and compared with the results of SMC experiment. The agreement is satisfactory except for the points at the three lowest x, which have an important role in the SMC evaluation on the L.H.S. of the Bjorken sum rule.
Phenomenology of a Supersymmetric Model for Fermion Mass Hierarchy
Authors: Liu Chun 
Published: October 2003

Some phenomenological aspects of a supersymmetric model for fermion mass hierarchy proposed previously are discussed. It is required that the lepton universality violation is near to its current experimental bound. The lepton number violation decay modes τ→2eμ and 3μ maybe observable in the near future. The Majorana mass of electron-neutrino is predicted to be about 0.1 eV. The fine-tuning problem is discussed.
Asymptotic States in Nonlocal Field Theories
Authors: Barci D. G. , Oxman L. E. 
Published: October 2003

Asymptotic states in field theories containing nonlocal kinetic terms are analyzed using the canonical method, naturally defined in Minkowski space. We apply our results to study the asymptotic states of a nonlocal Maxwell–Chern–Simons theory coming from bosonization in (2+1) dimensions. We show that in this case the only asymptotic state of the theory, in the trivial (non-topological) sector, is the vacuum.
The Superstring Propagator and the Signature of Space-Time
Authors: Pollock M. D. 
Published: October 2003

The Faddeev (Newton–Wigner) propagator K for the heterotic superstring theory is derived from the Wheeler–DeWitt equation for the wave function of the Universe Ψ, obtained in the four-dimensional (mini-superspace) Friedmann space-time ds2=dt2-a2(t)dx2, after reduction from the ten-action. The effect of higher-derivative terms ℛ2 is to break the local invariance under time reparametrization to a global symmetry t→λt, and consequently there are no ghost or gauge-fixing contributions, a functional integral over the (constant) Lagrange multiplier λ being sufficient to enforce the Hamiltonian constraint implicitly. After Wick rotation of the time, [Formula: see text], the only physically acceptable solution for K decreases exponentially on the Planck time-scale ~ t P , explaining from the quantum cosmological viewpoint why the signature of space-time is Lorentzian rather than Euclidean. This is analogous to the case of the (two-dimensional) free relativistic scalar particle, discussed recently by Redmount and Suen, who found that the propagator decreases exponentially outside the light-cone on the scale of the Compton wavelength of the particle (in accordance with the Heisenberg indeterminacy principle). These two seemingly different forms of acausality are thus physically excluded in the same way. The propagator for the Schwarzschild black hole of mass M is also obtained from the Schrödinger equation for the wave function on the apparent horizon, due to Tomimatsu, and the Hawking temperature T H =(8π M)-1 is derived from the Euclidean form of this equation.
Dynamics of the Universal Confining String Theory on the Loop Space
Authors: Antonov D. V. 
Published: October 2003

Starting with the representation of the Wilson average in the Euclidean 4D compact QED as a partition function of the universal confining string theory, we derive the corresponding loop equation, an alternative to the familiar one. In the functional momentum representation the obtained equation decouples into two independent ones, which describe the dynamics of the transverse and longitudinal components of the area derivative of the Wilson loop. At some critical value of the momentum discontinuity, which can be determined from a certain equation, the transverse component does not propagate. Next, we derive the equation for the momentum Wilson loop, where the left-hand side represents the sum of the squares of the momentum discontinuities, multiplied by the loop, which describes its free propagation, while the right-hand side describes the interaction of the loop with the functional vorticity tensor current. Finally, using the method of inversion of the functional Laplacian, we obtain for the Wilson loop in the coordinate representation a simple Volterra type-II linear integral equation, which can be treated perturbatively.