bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contenido de hule y resina en diploides, tetraploides e hibridos en guayule (Parthenium argentatum G.)
Authors: Kuruvadi Sathyanarayanaiah , Guzmán Medrano Edgar E. , Borrego Escalante Fernando , Mariano Escobedo Encarnación 
Published: January 2024

Se evaluaron diez genotipos de guayule, de los cuales fueron dos diploi-des, cinco tetraploides y tres híbridos en dos años consecutivos (1985-1986) bajo temporal, con el objetivo de comparar las características agronómicas y estudiar correlaciones fenotípicas. El análisis de varianza indicó diferencias altamente significativas para las características: porcentaje de hule, resina, altura y cobertura en ambos años y, además, el análisis combinado
El porcentaje de hule varió entre 2.98% a 10.08% y 3.6 a 12.2% en los años 1985 y 1986, respectivamente. Los tetraploides produjeron el máximo contenido de hule siguiéndole los diploides y los híbridos interespecificos. Los tetra-ploides manifestaron 43.24 y 166.71% de más porcentaje de hule, en comparación con los diploides e híbridos respectivamente en el año de 1985; esta misma tendencia se observó también en 1986. Los genotipos UAAAN6001. G. 11604, A48118 y G11605 sobresalieron para el rendimiento de hule a través de los dos años. Los híbridos expresaron alta vigorosidad en crecimiento, altura, cobertura y grosor del tallo, los cuales contribuyeron para aumentar la biomasa.
Se detectó una asociación positiva y altamente significativa entre el porcentaje de hule y resina. Además se encontró una fuerte correlación entre altura con cobertura y grosor del tallo.
Efecto de bajas temperaturas en huevecillos y larvas de la palomilla de la papa Phthorimaea operculella (Zeller) bajo condiciones de laboratorio.
Authors: Guerrero Rodriguez Eugenio , Hernández Velazquez Victor M. 
Published: January 2024

Con el objetivo de determinar la influencia de bajas temperaturas en el desarrollo de huevecillos y larvas de la palomilla de la papa, y sus efectos en los adultos sobrevivientes, se diseñó el presente trabajo que se desarrolló en el laboratorio de cría de insectos de la Universidad Autónoma Agraria Antonio Na-rro, en el período de diciembre de 1987 a junio de 1988.
Con la finalidad de evaluar la protección del suelo en tubérculos expuestos directamente al frío y cubiertos con suelo de la acción de cinco temperaturas 10, 5, 0, -5 y -10°C, actuando por cinco horas sobre huevecillos, larvas de primero, segundo, tercero y cuarto estadio, se estableció el estudio en un experimento con diseño completamente al azar en arreglo factorial 2x5x5 con tres repeticiones.
El número de adultos disminuyó considerablemente en las temperaturas de -5 y -10°C, hasta casi un 40% en esta última, siendo la mortalidad muy leve en 0°C; por lo que respecta a peso de pupas, la exposición a bajas temperaturas en los estados inmaduros de desarrollo, tuvieron efectos secundarios, y disminuyó el peso de pupas, pero únicantente afectó a las hembras; en lo que se refiere a longitud, extensión alar y fecundidad, las hembras no fueron afectadas por las bajas temperaturas.
Exploring Factors Contributing to Indifference Towards Learning Mathematics Among Secondary School Students in Nepal
Authors: Pokhrel Maheshwor 
Published: January 2024

Abstract

Mathematics is a compulsory subject at the school level in Nepal, deemed essential for everyday life and higher studies, particularly in the fields of science and technology. However, there is a noticeable apathy among students when it comes to learning mathematics. This qualitative research aims to identify the factors that contribute to this indifference towards learning mathematics. Data was collected through in-depth interviews with four participants from both public and private schools, all enrolled in the tenth grade. Analysis and interpretation of the data revealed several factors that lead to this indifference. These factors can be classified as student-related, school-related, and home and society-related. Student-related factors include mathematics anxiety, negative perceptions, insufficient effort, poor academic achievements, limited real-world applications, low self-efficacy, and perpetuation of misconceptions about mathematics. School-related factors encompass teaching practices, teacher qualifications, traditional methods focused on rote learning, impractical curriculum and courses, inadequate school administration, and subpar physical facilities. Home and society-related factors have a negative effect on mathematics engagement, such as unfavorable home environments, low socioeconomic status, and parental education. Together, these factors contribute to the observed indifference towards learning mathematics.
Keywords: Indifference, Qualitative, Mathematics, Factors, Home, Students, School
PERSETUJUAN TINDAKAN KEDOKTERAN ( INFORMED CONSENT) DALAM PRESPEKTIF HUKUM
Authors: Kusnadi Kusnadi 
Published: January 2024

Informed Consent mengandung pengertian suatu persetujuan yang diberikan oleh pasien atau keluarganya setelah mendapat informasi tindakan medis yang akan dilakukan terhadap dirinya serta segala resiko. Peraturan Menteri Kesehatan Nomor 290/Menkes/Per/III/2008 tentang Persetujuan Tindakan Kedokteran (selanjutnya disebut Permenkes Pertindok). Istilah persetujuan tindakan kedokteran itu sendiri terdapat pada Pasal 1 angka 1 yang menyatakan bahwa persetujuan yang diberikan oleh pasien atau keluarga terdekat setelah mendapat penjelasan secara lengkap mengenai tindakan kedokteranyang akan dilakukan terhadap pasien. Pelaksanaan hak atas persetujuan tindakan medis atas informasi, juga dicantumkan pada ketentuan Pasal 7 Undang-Undang Nomor 36 Tahun 2009 tentang Kesehatan. Tetapi, dalam pelaksanaan tindakan medis berupa implied consent untuk keadaan emergency, terhadap pasien gawat darurat, tidak dimungkinkan bagi pasien maupun wali dan keluarga pasien untuk mendapatkan informasi terlebih dahulu, karena pasien harus segera dilakukan tindakan untuk penyelamatan nyawa oleh dokter dengan melakukan tindakan medik terbaik menurut dokter.
Informed Consent contains the meaning of an agreement given by the patient or his family after receiving information on the medical actions that will be taken against him and all risks. Regulation of the Minister of Health Number 290/Menkes/Per/III/2008 concerning Approval of Medical Measures (hereinafter referred to as Permenkes Pertindok). The term approval of medical actions itself is contained in Article 1 number 1 which states that the consent given by the patient or closest family after receiving a complete explanation of the medical action that will be carried out on the patient. The implementation of the right to approval of medical actions for information is also included in the provisions of Article 7 of Law Number 36 of 2009 concerning Health. However, in the implementation of medical actions in the form of implied consent for emergencies, for emergency patients, it is not possible for patients or guardians and families of patients to get information in advance, because patients must immediately take action to save lives by doctors by doing the best medical actions according to doctors.
“We are never allowed to just be ourselves!”
Authors: Kristensen Morten Stinus 
Published: January 2024

For several decades, mainstream media have positioned Muslims as cultural, political, and social outsiders to Denmark. Danish Muslims confront and navigate this exclusionary racial project of hegemonic Danishness in a host of ways, including through online communication and social media practices. This article is a qualitative study of Danish Muslims who produce discursive interventions on social media platforms such as Facebook and Instagram in direct and indirect relation to mainstream media discourses on Muslimness. Their social media practices are conceptualized as part of an emerging, online Danish Muslim counterpublic where features that afford interactivity shape the counterpublic to be communal in distinct ways. This digital counterpublic provides direct challenges to hegemonic Danishness’ one-dimensional representation of Muslimness. Particularly when it comes to questions of gender and claims to ordinariness through quotidian posts on life as a Danish person who just happens to be Muslim, these social media practices are racial projects that undercut hegemonic Danishness’ racialization of Muslimness as non-Danish, monolithic, and culturally deficient.
magic of feminist bridging
Authors: Collective Loving Coalitions 
Published: January 2024

Are feminist coalitions magical enough to survive and endure while questioning and shaking the colonial/racist foundations of Swedish academic knowledge production and the overall Swedish society? Can feminist bridging and collective writing remain a magical process even when grappling with difficult experiences and memories of othering and racialisation? This is a creatively and collectively written article on feminist coalition building, and its importance in thinking, articulating and deconstructing race, racialization and racist structures. More than two years ago, seven interdisciplinary gender studies scholars of mixed ethnic and racial origins, came together to explore our differently situated experiences of disidentifying with Swedish academia and society in a collective we call Loving Coalitions. Against the background of Swedish exceptionalism, historical amnesia of Sweden’s colonial past and present, and the deafening silence on Swedish whiteness and racism, we are sharing our poems, letters, texts and testimonies of racist interactions in Swedish academia and society. While doing so, we discuss how moving away from conventional ways of doing research and experimenting with creative methodological alternatives, such as automatic writing, epistolary formats, poems, fiction, collective memory-work, allow us to acknowledge and embrace our different life backgrounds and academic trajectories as a mode of knowledge production. We hope and believe that our experiences, refl ections and ways to resist racism and Othering in Sweden and Swedish academia through alternative coalition building, based on mutual care and love, can be relevant in a Danish context as well.
The Circular Economy in Terms of Zinc Recovery from Industrial Waste – Directions for the Development and Profitability of Recycling
Authors: Bobrowski Artur , Nejranowski Aleksander 
Published: January 2024

The article reviews the current state of the art in the field of zinc recycling. The results of model studies of the profitability (profitability) of the process of zinc recovery in precipitation in the form of dusts and sludges are presented. The cost of purchasing waste and the necessary energy and material expenditures were taken into account. It has been shown that access to a cheap source of waste is essential for the profitability of the zinc recovery process.
Dengue viremia kinetics and effects on platelet count and clinical outcomes: An analysis of 2340 patients from Vietnam
Authors: Vuong Nguyen Lam , Quyen Nguyen Than Ha , Tien Nguyen Thi Hanh , Duong Thi Hue Kien , Duyen Huynh Thi Le , Lam Phung Khanh , Tam Dong Thi Hoai , Van Ngoc Tran , Jaenisch Thomas , Simmons Cameron P , Yacoub Sophie , Wills Bridget A , Geskus Ronald 
Published: January 2024

Background:Viremia is a critical factor in understanding the pathogenesis of dengue infection, but limited data exist on viremia kinetics. This study aimed to investigate the kinetics of viremia and its effects on subsequent platelet count, severe dengue, and plasma leakage.Methods:We pooled data from three studies conducted in Vietnam between 2000 and 2016, involving 2340 dengue patients with daily viremia measurements and platelet counts after symptom onset. Viremia kinetics were assessed using a random effects model that accounted for left-censored data. The effects of viremia on subsequent platelet count and clinical outcomes were examined using a landmark approach with a random effects model and logistic regression model with generalized estimating equations, respectively. The rate of viremia decline was derived from the model of viremia kinetics. Its effect on the clinical outcomes was assessed by logistic regression models.Results:Viremia levels rapidly decreased following symptom onset, with variations observed depending on the infecting serotype. DENV-1 exhibited the highest mean viremia levels during the first 5–6 days, while DENV-4 demonstrated the shortest clearance time. Higher viremia levels were associated with decreased subsequent platelet counts from day 6 onwards. Elevated viremia levels on each illness day increased the risk of developing severe dengue and plasma leakage. However, the effect size decreased with later illness days. A more rapid decline in viremia is associated with a reduced risk of the clinical outcomes.Conclusions:This study provides comprehensive insights into viremia kinetics and its effect on subsequent platelet count and clinical outcomes in dengue patients. Our findings underscore the importance of measuring viremia levels during the early febrile phase for dengue studies and support the use of viremia kinetics as outcome for phase-2 dengue therapeutic trials.Funding:Wellcome Trust and European Union Seventh Framework Programme.
The effect of combining antibiotics on resistance: A systematic review and meta-analysis
Authors: Siedentop Berit , Kachalov Viacheslav N , Witzany Christopher , Egger Matthias , Kouyos Roger D , Bonhoeffer Sebastian 
Published: January 2024

Background:Under which conditions antibiotic combination therapy decelerates rather than accelerates resistance evolution is not well understood. We examined the effect of combining antibiotics on within-patient resistance development across various bacterial pathogens and antibiotics.Methods:We searched CENTRAL, EMBASE, and PubMed for (quasi)-randomised controlled trials (RCTs) published from database inception to 24 November 2022. Trials comparing antibiotic treatments with different numbers of antibiotics were included. Patients were considered to have acquired resistance if, at the follow-up culture, a resistant bacterium (as defined by the study authors) was detected that had not been present in the baseline culture. We combined results using a random effects model and performed meta-regression and stratified analyses. The trials’ risk of bias was assessed with the Cochrane tool.Results:42 trials were eligible and 29, including 5054 patients, qualified for statistical analysis. In most trials, resistance development was not the primary outcome and studies lacked power. The combined odds ratio for the acquisition of resistance comparing the group with the higher number of antibiotics with the comparison group was 1.23 (95% CI 0.68–2.25), with substantial between-study heterogeneity (I2=77%). We identified tentative evidence for potential beneficial or detrimental effects of antibiotic combination therapy for specific pathogens or medical conditions.Conclusions:The evidence for combining a higher number of antibiotics compared to fewer from RCTs is scarce and overall compatible with both benefit or harm. Trials powered to detect differences in resistance development or well-designed observational studies are required to clarify the impact of combination therapy on resistance.Funding:Support from the Swiss National Science Foundation (grant 310030B_176401 (SB, BS, CW), grant 32FP30-174281 (ME), grant 324730_207957 (RDK)) and from the National Institute of Allergy and Infectious Diseases (NIAID, cooperative agreement AI069924 (ME)) is gratefully acknowledged.
Genome-wide identification of the MADS-box gene family in Avena sativa and its role in photoperiod-insensitive oat
Authors: Nan Jinsheng , An Jianghong , Yang Yan , Zhao Guofen , Yang Xiaohong , Liu Huiyan , Han Bing 
Published: January 2024

Background
Traditional spring-summer sown oat is a typical long-day crop that cannot head under short-day conditions. The creation of photoperiod-insensitive oats overcomes this limitation. MADS-box genes are a class of transcription factors involved in plant flowering signal transduction regulation. Previous transcriptome studies have shown that MADS-box genes may be related to the oat photoperiod.

Methods
Putative MADS-box genes were identified in the whole genome of oat. Bioinformatics methods were used to analyze their classification, conserved motifs, gene structure, evolution, chromosome localization, collinearity and cis-elements. Ten representative genes were further screened via qRT‒PCR analysis under short days.

Results
In total, sixteen AsMADS genes were identified and grouped into nine subfamilies. The domains, conserved motifs and gene structures of all AsMADS genes were conserved. All members contained light-responsive elements. Using the photoperiod-insensitive oat MENGSIYAN4HAO (MSY4) and spring-summer sown oat HongQi2hao (HQ2) as materials, qRT‒PCR analysis was used to analyze the AsMADS gene at different panicle differentiation stages under short-day conditions. Compared with HQ2, AsMADS3, AsMADS8, AsMADS11, AsMADS13, and AsMADS16 were upregulated from the initial stage to the branch differentiation stage in MSY4, while AsMADS12 was downregulated. qRT‒PCR analysis was also performed on the whole panicle differentiation stages in MSY4 under short-day conditions, the result showed that the expression levels of AsMADS9 and AsMADS11 gradually decreased. Based on the subfamily to which these genes belong, the above results indicated that AsMADS genes, especially SVP, SQUA and Mα subfamily members, regulated panicle development in MSY4 by responding to short-days. This work provides a foundation for revealing the function of the AsMADS gene family in the oat photoperiod pathway.
Virtual screening of flavonoids as potential RIPK1 inhibitors for neurodegeneration therapy
Authors: Bepari Asim Kumar , Shatabda Swakkhar , Reza Hasan Mahmud 
Published: January 2024

Background
Global prevalence of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease is increasing gradually, whereas approvals of successful therapeutics for central nervous system disorders are inadequate. Accumulating evidence suggests pivotal roles of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in modulating neuroinflammation and necroptosis. Discoveries of potent small molecule inhibitors for RIPK1 with favorable pharmacokinetic properties could thus address the unmet medical needs in treating neurodegeneration.

Methods
In a structure-based virtual screening, we performed site-specific molecular docking of 4,858 flavonoids against the kinase domain of RIPK1 using AutoDock Vina. We predicted physicochemical descriptors of the top ligands using the SwissADME webserver. Binding interactions of the best ligands and the reference ligand L8D were validated using replicated 500-ns Gromacs molecular dynamics simulations and free energy calculations.

Results
From Vina docking, we shortlisted the top 20 flavonoids with the highest binding affinities, ranging from −11.7 to −10.6 kcal/mol. Pharmacokinetic profiling narrowed down the list to three orally bioavailable and blood-brain-barrier penetrant flavonoids: Nitiducarpin, Pinocembrin 7-O-benzoate, and Paratocarpin J. Next, trajectories of molecular dynamics simulations of the top protein-ligand complexes were analyzed for binding interactions. The root-mean-square deviation (RMSD) was 1.191 Å (±0.498 Å), 1.725 Å (±0.828 Å), 1.923 Å (±0.942 Å), 0.972 Å (±0.155 Å) for Nitiducarpin, Pinocembrin 7-O-benzoate, Paratocarpin J, and L8D, respectively. The radius of gyration (Rg) was 2.034 nm (±0.015 nm), 2.0.39 nm (± 0.025 nm), 2.053 nm (±0.021 nm), 2.037 nm (±0.016 nm) for Nitiducarpin, Pinocembrin 7-O-benzoate, Paratocarpin J, and L8D, respectively. The solvent accessible surface area (SASA) was 159.477 nm2 (±3.021 nm2), 159.661 nm2 (± 3.707 nm2), 160.755 nm2 (±4.252 nm2), 156.630 nm2 (±3.521 nm2), for Nitiducarpin, Pinocembrin 7-O-benzoate, Paratocarpin J, and L8D complexes, respectively. Therefore, lower RMSD, Rg, and SASA values demonstrated that Nitiducarpin formed the most stable complex with the target protein among the best three ligands. Finally, 2D protein-ligand interaction analysis revealed persistent hydrophobic interactions of Nitiducarpin with the critical residues of RIPK1, including the catalytic triads and the activation loop residues, implicated in the kinase activity and ligand binding.

Conclusion
Our target-based virtual screening identified three flavonoids as strong RIPK1 inhibitors, with Nitiducarpin exhibiting the most potent inhibitory potential. Future in vitro and in vivo studies with these ligands could offer new hope for developing effective therapeutics and improving the quality of life for individuals affected by neurodegeneration.
Short Estrous Cycle Post-ovulation in Peri-pubertal Sahiwal and Jersey Crossbred Heifers
Authors: Sharma Pururava , Kumar Pravesh , Sharma Akshay , Negi Vijender , Kumar Harish , Sood Pankaj 
Published: January 2024

This investigation focuses on analysing the follicular dynamics exhibited during peri-pubertal period in Sahiwal and Jersey crossbred heifers. The aim of the study was to assess first ovulation in the heifers following puberty (N=20; 10 for each breed). Heifers were subjected to alternate day trans-rectal ultrasonography (TRUS) when the diameter of dominant follicle surpassed 9 mm diameter. Transrectal ultrasonography (TRUS) was performed to observe and assess first ovulation in heifers. The size of the first pre-ovulatory follicle in Sahiwal and Jersey Crossbred heifer in peri-pubertal stage was 10.52±0.13 and 10.15±0.51 mm, respectively and the corpus luteum attained its maximum size of 13.89 and 11.26 mm, was significantly different (p<0.01) at day 8.6±0.4 and 8.2±0.48 in Sahiwal and Jersey crossbred heifers, respectively. The regression of corpus luteum (CL) adjudged by the Colour Doppler initiated on 10.6±0.4 and 11.0±0.63 day for Sahiwal and Jersey crossbred heifers, respectively. Some other follicular dynamics parameters i.e. day of wave onset, number of follicles recruited, inter-wave duration along with maximum diameter of dominant follicle, day of maximum diameter, growth rate, length of growth and static phase, duration of static phase and onset of atresia was recorded, however, no significant difference (p>0.05) was recorded between breeds. On an interesting note, the next estrous cycle for heifers did not lead to ovulation despite having follicular size more than10 mm in both the breeds.
Conclusion: In peroration, peri-pubertal Sahiwal and Jersey crossbred heifers had notably precocious luteal regression after first ovulation, without subsequent ovulation in next estrous cycle.