bluuebunny/crossref_metadata_2025_split huggingface dataset:
ЗМІНИ ВМІСТУ ОКИСНО МОДИФІКОВАНИХ ПРОТЕЇНІВ У ЩУРІВ-САМИЦЬ З ПАТОЛОГІЄЮ ЯЄЧНИКІВ ТА КОРЕКЦІЯ ЇХ ПРЕПАРАТАМИ ІНОЗИТОЛУ
Authors: Терлецька Н. Ю. , Денефіль О. В. 
Published: October 2023

РЕЗЮМЕ. Проблема безпліддя є на сьогодні досить актуальною. Серед факторів його розвитку є вік, стреси, малорухомий спосіб життя, токсична дія солей важких металів. При цьому відбувається руйнування клітинних мембран, до складу яких входять білки і фосфоліпіди. Застосування інозитоловмісних препаратів сприяє відновленню білків, що покращує репродуктивну функцію.
Мета – оцінка розвитку карбонільного стресу у щурів-самиць з патологією яєчників та проведеної корекції препаратами інозитолу (Ін).
Матеріал і методи. Досліди виконано на 144 білих щурах-самицях лінії Вістар, яких поділено на 4 серії: 1 – контроль, 3,5–4-місячні щури, 2 – щури 7,5–8 місяців, 3 – щури, яким 15 днів інтрагастрально вводили розчин ацетату свинцю у дозі 0,05 мг/кг, 4 – гіподинамічний стрес. У кожній серії було по 6 груп тварин: А – контроль (К), Б – Ін, В – FT 500 plus (FT), Г – вагітність, Д – вагітність + Ін, Е – вагітність + FT. Ін та FT вводили інтрагастрально 15 днів з розрахунку 400 мг/кг Ін. Визначали у сироватці крові та яєчниках окисно модифіковані протеїни при довжинах хвиль 370, 430, 530 нм.
Результати. У сироватці крові К Ін спричинив зростання ОМП370 і ОMП430, а FT – зменшення ОMП430. У 2А, 3А, 4А, порівняно з 1А, зросли всі ОМП. У 2Б, 3Б, 4Б і 2В, 3В, 4В, порівняно з 2А, 3А і 4А, зменшилися усі ОМП, але вони не досягали 1Б і 1В.
При розгляді яєчників тварин 1 серії, яким уводили Ін, порівняно з К, відмічено гіперемію. Ін і FT спричинили зростання ОМП370 і ОMП430, зменшення ОMП530, а FT – зменшення ОMП430 у сироватці крові. У 2А, 3А і 4А, порівняно з 1А, зросли всі ОМП. У 2Б, 3Б, 4Б і 2В, 3В, 4В, порівняно з 2А, 3А і 4А, зменшилися усі ОМП, але вони не досягали значень щурів 1Б і 1В.
У К самиць-породіль, яким до вагітності уводили Ін і FT, ОМП у сироватці крові були значно меншим. У 2Г, 4Г, порівняно з 1Г, зросли усі ОМП, у 3Г – ОМП370. У 2Д, 4Д і 2Е, 3Е, 4Е, порівняно з 2Г, 3Г і 4Г, зменшилися усі ОМП, а у 3Д – О??МП370.
У К самиць-породіль, яким до вагітності уводили Ін і FT ОМП у яєчниках були значно меншими. У 2Г, порівняно з 1Г, зросли ОМП370 і ОMП430, у 3Гі 4Г – усі ОМП. У 2Д, 4Д і 2Е, 3Е, 4Е, порівняно з 2Г, 3Г і 4Г, зменшилися усі ОМП, а у 3Д – ОМП370 і ОMП430.
Висновок. Препарати інозитолу у дозі 400 мг/кг не доцільно використовувати в експерименті у здорових молодих щурів-самиць. У 7,5–8 місячних самиць, у тварин, які зазнали впливу нанодоз ацетату свинцю, гіподинамічного стресу оптимальними для зменшення руйнування білків є як інозитол, так і FT 500 plus, хоча й останній ефективніший. Ефективність при застосуванні перед вагітністю як інозитолу, так і FT 500 plus висока, що проявляється меншим накопиченням окисно модифікованих протеїнів як у сироватці крові, так і у яєчниках щурів після пологів.
Information-Restricted Neural Language Models Reveal Different Brain Regions’ Sensitivity to Semantics, Syntax, and Context
Authors: Pasquiou Alexandre , Lakretz Yair , Thirion Bertrand , Pallier Christophe 
Published: October 2023

Abstract
A fundamental question in neurolinguistics concerns the brain regions involved in syntactic and semantic processing during speech comprehension, both at the lexical (word processing) and supra-lexical levels (sentence and discourse processing). To what extent are these regions separated or intertwined? To address this question, we introduce a novel approach exploiting neural language models to generate high-dimensional feature sets that separately encode semantic and syntactic information. More precisely, we train a lexical language model, GloVe, and a supra-lexical language model, GPT-2, on a text corpus from which we selectively removed either syntactic or semantic information. We then assess to what extent the features derived from these information-restricted models are still able to predict the fMRI time courses of humans listening to naturalistic text. Furthermore, to determine the windows of integration of brain regions involved in supra-lexical processing, we manipulate the size of contextual information provided to GPT-2. The analyses show that, while most brain regions involved in language comprehension are sensitive to both syntactic and semantic features, the relative magnitudes of these effects vary across these regions. Moreover, regions that are best fitted by semantic or syntactic features are more spatially dissociated in the left hemisphere than in the right one, and the right hemisphere shows sensitivity to longer contexts than the left. The novelty of our approach lies in the ability to control for the information encoded in the models’ embeddings by manipulating the training set. These “information-restricted” models complement previous studies that used language models to probe the neural bases of language, and shed new light on its spatial organization.
Asymmetric Error Correction in the Synchronization Tapping Task
Authors: Tomyta Kenta , Ohira Hideki , Katahira Kentaro 
Published: October 2023

Abstract
In synchronization tapping tasks, tapping onset often precedes metronome one by a few tens of milliseconds, which is known as negative mean asynchrony. However, the mechanism by which negative mean asynchrony occurs remains incompletely understood. This study hypothesized that one of the mechanisms was the asymmetric error correction process for asynchrony. We examined this hypothesis using a generalized linear mixed model. The results suggested that the error correction rate for the positive asynchrony was larger than that for the negative asynchrony. This finding may contribute to improving mathematical models of the synchronization tapping task.
Efficacy and Safety of a Single-Pill Triple Combination of Olmesartan, Amlodipine, and Rosuvastatin in Hypertensive Patients with Low-to-Moderate Cardiovascular Risk: A Multicenter, Randomized, Open-Label, Active-Control, Phase IV Clinical Trial
Authors: Kim Byung Jin , Cha Kwang Soo , Cho Wook Hyun , Kim Eung Ju , Choi Seung-Hyuk , Kim Moo Hyun , Kim Sang-Hyun , Park Jun-Bean , Park Seong-Mi , Sohn Il Suk , Ryu Kyu Hyung , Chae In-Ho 
Published: October 2023

Introduction This study evaluated the efficacy and safety of a single-pill triple-combination of olmesartan/amlodipine/rosuvastatin (Olme/Amlo/Rosu) in comparison with a single-pill dual-combination of olmesartan/amlodipine (Olme/Amlo) in hypertensive patients with low-to-moderate cardiovascular risk. Methods This multicenter, active-control, randomized study included 106 hypertensive patients at low-to-moderate cardiovascular risk who were randomly assigned to receive either Olme/Amlo/Rosu 20/5/5 mg (Treatment 1), Olme/Amlo/Rosu 20/5/10 mg (Treatment 2), or Amlo/Olme 20/5 mg (Control) once daily for 8 weeks. The primary endpoint was the difference of the percent change in low-density lipoprotein cholesterol (LDL-C) level at 8 weeks from baseline in the 3 groups. Results The difference in the least square mean percent change (standard deviation) of LDL-C in the Treatment 1 and 2 groups compared with the Control group at 8 weeks was −32.6 (3.7) % and −45.9 (3.3) %, respectively ( P < .001). The achievement rates of LDL-C level <100 mg/dL at 8 weeks were significantly different between the 3 groups (65.8%, 86.7%, and 6.3% for Treatment 1, 2, and Control groups, respectively, P < .001). The results of total cholesterol, triglycerides, high-density lipoprotein cholesterol, apolipoprotein B, and apolipoprotein B/apolipoprotein A1 were superior in the Treatment 1 and 2 groups compared with the Control group. Serious adverse drug reaction did not occur in the 3 groups. Medication adherence rates were excellent in the 3 groups (98.0% for Treatment 1 group, 99.7% for Treatment 2 group, and 96.3% for the Control group, P > .05). Conclusion Single-pill triple-combination of olmesartan/amlodipine/rosuvastatin was superior to the single-pill dual-combination of amlodipine/olmesartan in LDLC-lowering effects, with excellent safety profiles and adherence rates, in hypertensive patients at low-to-moderate cardiovascular risk. Trial Registration: CLinicalTrials.gov identifier NCT04120753.
Pregnancy in women with nephrotic-range proteinuria: A retrospective cohort study
Authors: Svetitsky Shuli , Lightstone Liz , Wiles Kate 
Published: October 2023

Background Obstetric and kidney outcomes following detection of nephrotic-range proteinuria in early pregnancy have not been well described. Methods A retrospective cohort study of chronic kidney disease (CKD) in pregnancy between 2008 and 2018. Outcomes in those with nephrotic-range proteinuria before 20 weeks’ gestation were compared to those without nephrotic-range proteinuria. Results The study included 37 women with nephrotic-range proteinuria and 62 women without. Pre-pregnancy estimated glomerular filtration rate (eGFR) was similar. Nephrotic-range proteinuria was associated with higher rates of preterm (odds ratio [OR] 1.77, 95% confidence interval [CI]: 1.07–2.92) and early preterm delivery (OR 2.63, 95% CI: 1.12–6.2), and with a requirement for renal replacement therapy at 3 years post-partum (OR 10.72, 95% CI: 2.58–44.47). Tubulointerstitial scarring on kidney biopsy was associated with early preterm delivery and progression to advanced CKD, independent of pre-pregnancy eGFR. Conclusion Compared to CKD without nephrotic-range proteinuria, nephrotic-range proteinuria early in pregnancy is associated with higher rates of pre-term delivery and progression to advanced CKD.
Structural connections of the centromedian nucleus of thalamus and their relevance for neuromodulation in generalized drug-resistant epilepsy: insight from a tractography study
Authors: Remore Luigi G. , Rifi Ziad , Nariai Hiroki , Eliashiv Dawn S. , Fallah Aria , Edmonds Benjamin D. , Matsumoto Joyce H. , Salamon Noriko , Tolossa Meskerem , Wei Wexin , Locatelli Marco , Tsolaki Evangelia C. , Bari Ausaf A. 
Published: October 2023

Background: Epilepsy is a widespread neurologic disorder and almost one-third of patients suffer from drug-resistant epilepsy (DRE). Neuromodulation targeting the centromediannucleus of the thalamus (CM) has been showing promising results for patients with generalized DRE who are not surgical candidates. Recently, the effect of CM- deep brain stimulation (DBS) in DRE patients was investigated in the Electrical Stimulation of Thalamus for Epilepsy of Lennox–Gastaut phenotype (ESTEL) trial, a monocentric randomized-controlled study. The same authors described a ‘cold-spot’ and a ‘sweet-spot’, which are defined as the volume of stimulation in the thalamus yielding the least and the best clinical response, respectively. However, it remains unclear which structural connections may contribute to the anti-seizure effect of the stimulation. Objective: We investigated the differences in structural connectivity among CM, the sweet-spot and the cold-spot. Furthermore, we tried to validate our results in a cohort of DRE patients who underwent CM-DBS or CM-RNS (responsive neurostimulation). We hypothesized that the sweet-spot would share similar structural connectivity with responder patients. Methods: By using the software FMRIB Software Library (FSL), probabilistic tractography was performed on 100 subjects from the Human Connectome Project to calculate the probability of connectivity of the whole CM, the sweet-spot and the cold-spot to 45 cortical and subcortical areas. Results among the three seeds were compared with multivariate analysis of variance (MANOVA). Similarly, the structural connectivity of volumes of tissue activated (VTAs) from eight DRE patients was investigated. Patients were divided into responders and non-responders based on the degree of reduction in seizure frequency, and the mean probabilities of connectivity were similarly compared between the two groups. Results: The sweet-spot demonstrated a significantly higher probability of connectivity ( p < 0.001) with the precentral gyrus, superior frontal gyrus, and the cerebellum than the whole CM and the cold-spot. Responder patients displayed a higher probability of connectivity with both ipsilateral ( p = 0.011) and contralateral cerebellum ( p = 0.04) than the non-responders. Conclusion: Cerebellar connections seem to contribute to the beneficial effects of CM-neuromodulation in patients with drug-resistant generalized epilepsy.
Remote Patient Monitoring for Hypertension: Feasibility and Outcomes of a Clinic-Based Pilot in a Minority Population
Authors: Makutonin Michael , Dare Justin , Heekin Mary , Salancy Abby , Hood Colton , Dominguez Luis W. 
Published: October 2023

Background: In the US 48% of adults have hypertension, with direct costs in excess of $130 billion per year. Remote patient monitoring (RPM) has been discussed as a useful tool in the treatment of hypertension, but few studies evaluate its cost effectiveness or efficacy in minority, lower socio-economic (SES) populations. Our study aims to evaluate the clinical and financial outcomes of RPM in hypertension management in a primarily minority, low-SES population. Methods: In this prospective cohort pilot study, patients with uncontrolled primary hypertension (defined via Joint National Committee 8 guidelines) were randomly selected from a single academically affiliated primary care clinic. Patients were enrolled on a rolling basis for 90 days. Patients were given blood pressure cuffs and transmission hubs and asked to transmit daily blood pressure readings. Patients were called weekly by research assistants and concerns were escalated to the primary care physician. The control group was the remaining 299 uncontrolled hypertensive patients from the same clinic population analyzed via retrospective chart records at the conclusion of the interventional study period. The primary outcome was blood pressure control. Secondary outcomes were relative improvement in systolic pressure and direct costs. Results: A total of 13 patients were enrolled into the RPM intervention; these patients were 54% female, 100% African American, and 77% Medicaid. When assessed via intention-to-treat analysis, patients in the intervention group had non-inferior blood pressure control at 90 days (46% experimental vs 31% control, P = .33) and average change in systolic blood pressure at 90 days (13.5 vs 3.7 mmHg, P = .174) while experiencing a significant reduction in office-based visits at 90 days (1.5 vs 5.9, P < .001) as compared to control. Results on per-protocol analysis also showed non-inferior BP control (63% vs 31%, P = .135). Financially, the program generated margins of $29 per patient at 90 days. Conclusions: Patients in our minority- and Medicaid-predominant cohort achieved noninferior blood pressure control as compared to retrospective control at 90 days and a significant reduction in all-cause clinic visits at 90 days. The program generated little revenue per patient, with main barriers to implementation including patient compliance and payor denial.
The shape-dependent inhibitory effect of rhein/silver nanocomposites on porcine reproductive and respiratory syndrome virus
Authors: Ren Caifeng , Ke Qiyun , Fan Xiaoxia , Ning Keke , Wu Yuan , Liang Jiangong 
Published: October 2023

AbstractTraditional Chinese medicines (TCMs)/nanopreparations as viral antagonists exhibited a structure–function correlation, i.e., the differences in surface area/volume ratio caused by the variations in shape and size could result in different biochemical properties and biological activities, suggesting an important impact of morphology and structure on the antiviral activity of TCM-based nanoparticles. However, few studies paid attention to this aspect. Here, the effect of TCM-based nanoparticles with different morphologies on their antiviral activity was explored by synthesizing rhein/silver nanocomposites (Rhe@AgNPs) with spherical (S-Rhe/Ag) and linear (L-Rhe/Ag) morphologies, using rhein (an active TCM ingredient) as a reducing agent and taking its self-assembly advantage. Using porcine reproductive and respiratory syndrome virus (PRRSV) as a model virus, the inhibitory effects of S-Rhe/Ag and L-Rhe/Ag on PRRSV were compared. Results showed that the product morphology could be regulated by varying pH values, and both S- and L-Rhe/Ag exhibited good dispersion and stability, but with a smaller size for L-Rhe/Ag. Antiviral experiments revealed that Rhe@AgNPs could effectively inhibit PRRSV infection, but the antiviral effect was morphology-dependent. Compared with L-Rhe/Ag, S-Rhe/Ag could more effectively inactivate PRRSV in vitro and antagonize its adsorption, invasion, replication, and release stages. Mechanistic studies indicated that Rhe@AgNPs could reduce the production of reactive oxygen species (ROS) induced by PRRSV infection, and S-Rhe/Ag also had stronger ROS inhibitory effect. This work confirmed the inhibitory effect of Rhe@AgNPs with different morphologies on PRRSV and provided useful information for treating PRRSV infection with metal nanoparticles synthesized from TCM ingredients.
Graphical abstract
Risk factors of stress urinary incontinence in pelvic organ prolapse patients: a systematic review and meta-analysis
Authors: Fitri Andiva Nurul , Kurniawati Eighty Mardiyan , Wiyasihati Sundari Indah , Wungu Citrawati Dyah Kencono 
Published: October 2023

AbstractBackgroundStress urinary incontinence (SUI) and pelvic organ prolapse (POP) commonly coexist as global problems that affect the quality of life of millions of women. The study aimed to identify the risk factors of stress urinary incontinence in pelvic organ prolapse patients.Main bodyA systematic review and meta-analysis was conducted in Web of Science, PubMed, and Scopus based on the PRISMA flowchart. The quality of the study was assessed using Newcastle–Ottawa Scale and data were collected on a modified table from The Cochrane Library. Meta-analysis was conducted using RevMan 5.4. Seven hundred forty studies were found that matched the keywords. After the screening, 16 studies met the inclusion and exclusion criteria with a total of 47.615 participants with pelvic organ prolapse. A total of 27 risk factors were found in this review. History of hysterectomy (OR = 2.01; 95% CI 1.22–3.33;p = 0.007), obesity (OR = 1.15; 95% CI 1.02–1.29;p = 0.02), and diabetes mellitus (OR = 1.85; 95% CI 1.06–3.23;p = 0.03) were shown to be risk factor of stress urinary incontinence in pelvic organ prolapse patients.ConclusionsHistory of hysterectomy, obesity, and diabetes mellitus were found to be the risk factors of stress urinary incontinence in pelvic organ prolapse patients.
Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps
Authors: Kim Jonghui , Hegener Karla , Hagedorn Claudia , Weidinger Daniel , Jamal Jameel Kashin , Seuthe Inga Marte Charlott , Eichhorn Sabine , Kreppel Florian , Park Jonas Jae-Hyun , Knobloch Jürgen 
Published: October 2023

Abstract
Background
Epithelial cells are an important part of the pathomechanism in chronic rhinosinusitis with nasal polyps. It is therefore essential to establish a robust method for the isolation and culture of epithelial cells from nasal polyps to enable further research. In this study, the feasibility of the outgrowth technique for the isolation of the epithelial cells from the nasal polyps was evaluated.

Results
Using the outgrowth technique, epithelial cells could be isolated from all tissue samples. Isolated epithelial cells showed a proliferation rate of approximately 7- to 23-fold every 6 days up to the 3rd passage. Over 97% of isolated cells were shown to be cytokeratin- and p63-positive, and over 86% of them were Ki-67–positive in flow cytometry. Interleukin-33 and periostin were detectable in the supernatant.

Conclusions
We introduce a simple, low-cost, and well-performing method for isolating epithelial cells from nasal polyps with the outgrowth technique.
Effects of personal and health characteristics on the intrinsic capacity of older adults in the community: a cross-sectional study using the healthy aging framework
Authors: Jiang Xin , Chen Fenghui , Yang Xuanxuan , Yang Mei , Zhang Xuehong , Ma Xuan , Yan Ping 
Published: October 2023

Abstract
Background
Intrinsic capacity (IC) can better reflect the physical functioning of older adults. However, few studies have been able to systematically and thoroughly examine its influencing factors and provide limited evidence for the improvement of intrinsic capacity. The objective of this study was to provide a comprehensive description of the overall decline in intrinsic capacity among older persons in the community. Additionally, the study aimed to analyze the composition of the five domains of reduction, compare the rate of decline among older adults and investigate the factors that influence this decline.

Methods
This was a cross-sectional study conducted in the Chinese community. The self-designed general characteristics questionnaire was created based on the healthy aging framework and a systematic review. Intrinsic capacity was assessed with the Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS-15), Community Health Record Management System (CHRMS), Mini Nutritional Assessment Brief Form (MNA-SF), and Short Physical Performance Battery (SPPB). The influencing factors of intrinsic capacity were investigated using stepwise logistic regression.

Results
A total of 968 older adults with a mean age of 71.00 (68.00, 76.75) were examined, and 704 older adults (72.7%) showed a decline in intrinsic capacity. There was a decline in at least one domain in 39.3% of older adults, with reductions in each domain ranging from 5.3% (psychological) to 52.4% (sensory). The study examined the composition of domains that experienced a decline in intrinsic capacity. It was found that a combination of sensory and locomotor domains showed the most significant decrease in 44.5% (n = 106) of individuals who experienced a decline in the two domains. Furthermore, a combination of sensory, cognitive, and locomotor domains exhibited a significant decrease in 51.3% (n = 44) of individuals who experienced a reduction in three domains. Lastly, a combination of sensory, vitality, cognitive, and locomotor domains showed the most significant decline in four domains, accounting for 60.0% (n = 15) of the population. Older adults had a higher risk of intrinsic capacity decline if they were older (95% CI:1.158–2.310), had lower education, lived alone (95% CI: 1.133–3.216), smoked (95% CI: 1.163–3.251), high Charlson Comorbidity Index (95% CI: 1.243–1.807) scores, did not regular exercise (95% CI:1.150–3.084), with lower handgrip strength (95% CI: 0.945–0.982).

Conclusions
We found a relatively high prevalence of intrinsic capacity; more attention should be paid to older adults who are older, less educated, live alone, and have more comorbidities. It is imperative to prioritize a healthy lifestyle among older persons who exhibit smoking habits, lack regular exercise, and possess inadequate handgrip strength.