bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes and treatment patterns for stage I human epidermal growth factor receptor 2‐positive breast cancer in the Surveillance, Epidemiology, and End Results database, 2010–2019
Authors: Waks Adrienne G. , Tarantino Paolo , Chen Emily L. , Freedman Rachel A. , Lin Nancy U. , Tayob Nabihah , Vallejo Carlos T. , Leone Julieta , Tolaney Sara M. , Leone Jose Pablo 
Published: January 2025

AbstractBackgroundThe risk of recurrence in patients with small, lymph node‐negative, human epidermal growth factor receptor 2 (HER2)‐positive breast cancers untreated with adjuvant chemotherapy/HER2‐directed therapy is uncertain. To investigate this, the authors conducted a retrospective, population‐based study of chemotherapy use and breast cancer‐specific survival (BCSS) among patients with stage IA HER2‐positive breast cancer.MethodsThe authors analyzed Surveillance, Epidemiology, and End Results data from patients diagnosed with stage IA HER2‐positive breast cancer from 2010 to 2019. They examined the frequency of chemotherapy use by tumor size and hormone receptor (HR) status and applied multivariate logistic regression to assess the factors associated with receipt of chemotherapy. BCSS was evaluated and performed multivariable Cox regression was performed to evaluate the association between chemotherapy receipt and BCSS.ResultsAmong 12,896 patients, 74.0% had HR‐positive/HER2‐positive breast cancer, and 26.0% had HR‐negative/HER2‐positive breast cancer. Adjuvant chemotherapy was received by to 58.9% of patients, with lower utilization for those who were older, Hispanic or Asian/Pacific Islander, separated/divorced/widowed, or had a lower median household income. The median follow‐up was 46 months. Among the patients who had pathologic T1 (pT1) microscopic, pT1a, or pT1b tumors, the 5‐year BCSS rate was 97.6%–99.6% in those who had no evidence of chemotherapy receipt in the medical record versus 98.4%–100.0% in those who did receive chemotherapy. Among patients who had pT1c tumors and had no evidence of chemotherapy receipt, the 5‐year BCSS rate was 92.1% for those with HR‐negative/HER2‐positive breast cancer and 96.0% for those with HR‐positive/HER2‐positive breast cancer. Patients who had pT1c tumors and received chemotherapy had a 5‐year BCSS rate of 96.7% in those with HR‐negative/HER2‐positive breast cancer and 98.7% in those with HR‐positive/HER2‐positive breast cancer.ConclusionsIn this large, population‐based study of patients with stage IA HER2‐positive breast cancer, patients who had tumors ≤1 cm had excellent outcomes with or without chemotherapy. Patients with pT1c tumors had a greater increase in BCSS with the receipt chemotherapy.
The Effectiveness of Multimodality Treatment Including Stabilization Splint and Low‐Level Laser Therapies on Managing Temporomandibular Disorders: A Pilot Randomized Controlled Trial
Authors: Afshari Zahra , Kookhi Nazieh Abdollah , Shamali Mahdi , Monfared Majid Sedaghat , Tavakolizadeh Sara 
Published: January 2025

ABSTRACTObjectivesTemporomandibular disorder (TMD) encompasses various clinical issues affecting the temporomandibular joint, masticatory muscles, and surrounding structures. Common symptoms include pain, joint and muscle tenderness, and limited jaw movement. Diverse treatment options have been utilized to manage TMD. However, evidence of the combined modality treatment approach is scarce. This pilot trial aimed to evaluate the effectiveness of combining stabilization splint therapy (SST) with low‐level laser therapy (LLLT) in managing TMD.Material and MethodsThis pilot parallel randomized clinical trial included 30 patients with TMD. Patients were randomly allocated equally into three treatment groups: SST, LLLT, and combined treatment (CT). Outcomes, including pain and functional limitations, were measured at baseline, 1, 2, 3, and 4 weeks after the start of each treatment.ResultsCT was significantly more effective in reducing pain in patients with TMD compared to LLLT and SST. Although patients in the LLLT group reported significantly reduced pain, they still had higher pain scores compared to the SST group at certain time points, indicating that LLLT was not as effective as SST. Most functional limitations were improved over time, more consistently within the CT group, but without significant differences between the three groups. Patients were more satisfied with CT compared to LLLT and SST.ConclusionsThe superior results of the CT group over the SST and LLLT groups were evident in this pilot trial's outcomes. The combined modality treatment approach seems to yield the greatest improvement for TMD patients.
Assessing the Correlation Between Langerhans Cells Population and Prognosis of Tongue Squamous Cell Carcinoma
Authors: Ghazi Narges , Saghravanian Nasrollah , Saeedi Pooya , Maboudinezhad Mohammad Mahdi 
Published: January 2025

ABSTRACTBackground and ObjectiveTongue squamous cell carcinoma (TSCC) is the most prevalent oral cancer. Despite considerable advancements in treatment, the 5‐year survival rate remains relatively unchanged. Langerhans cells (LCs) play an important role in antitumor immunity. Therefore, we attempt to evaluate the correlation between the LC count and disease prognosis.Materials and MethodsHistopathologic slides from 24 cases, with at least 2 years of follow‐up, were selected and categorized into early‐stage (12 cases) and advanced‐stage (12 cases) groups. An additional 12 slides of normal tissue comprised the control group. Immunohistochemical staining with the CD1a marker was performed to analyze the density of LCs. Statistical analysis assessed the impact of CD1a immune expression on patient survival and other variables such as age, gender, stage, and histopathological grade.ResultsComparison of CD1a+ cell counts across the three groups revealed a significant decrease in the advanced group. Furthermore, a lower count of CD1a+ cells correlated with poorer disease‐free survival (DFS) (p < 0.001) and overall survival (OS) (p = 0.049). Although the CD1a+ cell count did not independently affect OS significantly (p = 0.210), it did show a significant impact on DFS as an independent variable (p = 0.002).ConclusionThe significant correlation between CD1a expression and patients' prognosis and survival rates suggests that CD1a+ cells could serve as a crucial prognostic factor in the management and treatment of TSCC.
Transmitter‐Side Converter Controlled Wireless EV Charging System Tracing Maximum Efficiency Using Model Predictive Control
Authors: R Venugopal , C Balaji 
Published: January 2025

ABSTRACTDynamic response, lack of efficient power transfer, and high response time resulting in increased losses and reduced minimal efficiency are the major issues of the existing controls in the wireless power transfer (WPT) for EV charging applications. Model predictive (MP) control can handle several constraints and disturbances by predicting the future behavior of the system and generating control signals accordingly, making the system stable, and operating at high efficiency. This work proposes transmitter‐side model predictive (MP) control for the three‐level T‐type inverter–based wireless EV chargers. The prime focus of this article is attaining remarkable efficiency and offering CC/CV charging for the EV battery. The validation of the proposed MP control is carried out with a 3.3‐kW laboratory model. The steady‐state behavior and dynamic performance under sudden changes in the load and misalignment (vertical and horizontal) were studied in detail. The results provided validate the effectiveness of the proposed MP control.
A GPU‐Accelerated 3D Unstructured Mesh Based Particle Tracking Code for Multi‐Species Impurity Transport Simulation in Fusion Tokamaks
Authors: Nath Dhyanjyoti D. , Younkin Timothy R. , Guterl Jerome , Shephard Mark S. , Sahni Onkar 
Published: January 2025

ABSTRACTThis paper presents the multi‐species global impurity transport capability developed in a GPU‐accelerated fully 3D unstructured mesh‐based code, GITRm, to simultaneously track multiple impurity species and handle interactions of these impurities with mixed‐material surfaces. Different computational approaches to model particle‐surface interaction or surface response have been developed and compared. Sheath electric field is taken into account by employing a fast distance‐to‐boundary calculation, which is carried out in parallel on distributed or partitioned meshes on multiple GPUs without the need for any inter‐process communication during the simulation. Several example cases, including two for the DIII‐D tokamak, that is, one with the SAS‐V divertor and the other with the collector probes, are used to demonstrate the utility of the current multi‐species capability. For the DIII‐D probe case, the capability of GITRm to resolve the spatial distribution of particles in localized regions, such as diagnostic probes, within non‐axisymmetric tokamak geometries is demonstrated. These simulations involve up to 320 million particles and utilize up to 48 GPUs.
Wireless Sensing‐Based Remote Detection of Concealed Metallic Objects
Authors: Yousaf Muhammad Salman , Javed Imran , Loan Asim 
Published: January 2025

ABSTRACTConcealed weapon detection has gained widespread interest in recent times due to prevalent law and order situation. There is an ever‐increasing need of detection of body‐worn harmful objects from a safe distance to save precious human life and to cause minimal damage to infrastructure. Most of the conventional weapon detection schemes require proximity to target for detection. To alleviate the problem of close proximity, WiFi‐based wireless sensing has recently emerged as a promising technique for remote detection and sensing in different applications. The focus of this research is to implement a low cost and robust WiFi‐based wireless detection system for body‐worn concealed objects. The methodology is based on utilizing low‐cost WiFi sensors to acquire Channel State Information (CSI), smoothening/filtering of CSI data, extraction of different statistical parameters and building a model to differentiate among two cases of body‐plus‐weapon and body only. Probability density functions of the variance of CSI features are computed under metal and non‐metal scenarios, that are non‐overlapping, which validate the effectiveness of proposed approach to separate metal and non‐metal scenarios. Furthermore, heatmap images are generated and a deep learning model is trained to automate the detection process. Our deep learning‐based automated detection methodology has achieved an overall accuracy of 90.5% and 87.5% on test samples, respectively, for the detection of a metallic plate and a real gun in indoor setting at 20 ft distance from the antenna.
Inflammation biomarkers and Alzheimer's disease: A pilot study using NULISAseq
Authors: Di Molfetta Guglielmo , Pola Ilaria , Tan Kubra , Isaacson Richard , Blennow Kaj , Ashton Nicholas J. , Benedet Andrea L. , Zetterberg Henrik 
Published: January 2025

AbstractINTRODUCTIONIncreasing evidence links amyloid beta (Aβ) aggregation with inflammation. This pilot study investigated the use of an immunoassay panel to map biomarker changes in patients with Alzheimer's disease (AD). Furthermore, we evaluated the stability of protein quantification after multiple freeze–thaw cycles (FTCs).METHODSThe nucleic acid‐linked immuno‐sandwich assay (NULISA) inflammation panel measured 203 proteins in serum samples of individuals with (n = 31) and without (n = 31) AD pathology. Linear models, adjusted for age and sex, contrasted protein expression across groups.RESULTSAfter multiple‐testing adjustments, glial fibrillary acidic protein (p < 0.001) and S100A12 (p < 0.001) were significantly changed in the presence of AD pathology. Furthermore, they correlated with cerebrospinal fluid biomarkers (phosphorylated tau‐181 [p‐tau181], tau, and Aβ42). Additional markers were nominally changed between groups. Five FTCs caused minimal changes in measurements with the NULISA inflammation panel.DISCUSSIONMonitoring of inflammation in AD, using the 200‐plex NULISA panel, demonstrates changes in peripherally circulating inflammation‐related proteins. Contrary to previous reports, FTCs had minimal impact on the quantification of inflammatory markers.Highlights
The novel nucleic acid‐linked immuno‐sandwich assay (NULISA) inflammation panel, which includes 200 protein biomarkers, was used.
The panel was used for the first time in serum from patients with Alzheimer's disease (AD).
The protein S100A12 was identified as a potential biomarker for AD.
Inflammation markers were stable in up to five freeze–thaw cycles.
Successful treatment with hyperbaric oxygen therapy for ulcerative esophageal stricture after chemoradiotherapy: A case report
Authors: Tateda Tetsuyuki , Kikuchi Hidezumi , Furusawa Keisuke , Matsuoka Yusuke , Asari Taka , Sawada Yohei , Nakagawa Satoru , Tetsuya Tatsuta , Chinda Daisuke , Sakuraba Hirotake 
Published: January 2025

AbstractSevere esophageal strictures resulting from chemoradiotherapy pose persistent therapeutic challenges despite the availability of treatments such as endoscopic balloon dilation and medications. Hyperbaric oxygen therapy (HBOT) has emerged as a promising treatment option for refractory radiation‐induced injury to several organs. Herein, we present the case of a 79‐year‐old male patient with refractory radiation‐induced ulcerative esophageal strictures after chemoradiotherapy. Despite multiple interventions, including endoscopic balloon dilation, steroids, and proton‐pump inhibitors, the patient remained unable to tolerate oral intake. HBOT was initiated, leading to significant improvement in the esophageal ulcers and strictures within 1 month. HBOT was well tolerated; the patient experienced a sustained improvement in his quality of life. Two years after HBOT, esophagogastroduodenoscopy confirmed persistent improvement in esophageal ulcers and strictures. This case highlights the potential of HBOT as a therapeutic option for ulcerative esophageal strictures unresponsive to conventional treatments.
Efficacy and safety of endoscopic ultrasonography‐guided radiofrequency ablation of small pancreatic neuroendocrine neoplasms: A prospective, pilot study
Authors: Matsumoto Kazuyuki , Uchida Daisuke , Takeuchi Yasuto , Kato Hironari , Fujii Yuki , Harada Kei , Hattori Nao , Sato Ryosuke , Obata Taisuke , Matsumi Akihiro , Miyamoto Kazuya , Horiguchi Shigeru , Tsutsumi Koichiro , Yasui Kazuya , Harada Ryo , Fujii Masakuni , Otsuka Motoyuki 
Published: January 2025

AbstractObjectivesEndoscopic ultrasonography (EUS)‐guided radiofrequency ablation has recently been introduced as one of the management strategies for small pancreatic neuroendocrine neoplasms (PNENs). However, prospective data on its safety and efficacy remain limited.MethodsThis prospective pilot study was conducted at Okayama University Hospital from May 2023 to December 2024. Patients with grade 1 PNENs ≤15 mm, confirmed by EUS‐guided fine‐needle aspiration, were included. The primary endpoint was safety (adverse events [AEs] evaluated according to the 2010 guidelines of the American Society for Gastrointestinal Endoscopy. Severe AEs were defined as moderate or higher in American Society for Gastrointestinal Endoscopy grading and grade ≥3. Secondary endpoints included efficacy (complete response on contrast‐enhanced computed tomography at 1 and 6 months), treatment details, device failure, diabetes mellitus exacerbation, and overall survival at 6 months.ResultsFive patients with non‐functional PNENs (median age: 64 years; median tumor size: 10 mm) were treated. AEs occurred in two patients (40%, 2/5), although none was severe. Both patients developed asymptomatic pseudocysts, one experienced mild pancreatitis, and both resolved with conservative treatment. The complete response rates on contrast‐enhanced computed tomography at one and 6 months were 100%. The median procedure time was 16 min without any device failure, and the median hospitalization was 5 days. None of the patients developed new‐onset or worsening diabetes mellitus. The 6‐month overall survival rate was 100%.ConclusionEUS‐guided radiofrequency ablation demonstrated a high complete response rate with no severe AEs in this pilot study, suggesting a minimally invasive option for small, low‐grade PNENs (jRCTs062230014).
Comparative Analyses of Gut Microbiomes in Hycleus cichorii (Coleoptera: Meloidae) Adults Reveal Their Distinct Microbes, Microbial Diversity and Composition Associated to Food
Authors: Yi Chunyan , Gao Li , Zhang Cuicui , Wang Yanping , Liu Xu , Yang Yongli , Chen Song , Du Chao 
Published: January 2025

ABSTRACTGut microbiota crucially affects metabolism and health. Hycleus cichorii Linnaeus has been listed as a medicinal insect in the Pharmacopeia of the People's Republic of China due to the presence of cantharidin, which has a curative effect on many cancers and skin diseases. In order to analyze the effects of dietary habits and gender on the diversity and composition of gut microbiota in H. cichorii and provide a basis for an artificial diet, in this study, the full‐length 16S rRNA sequencing technology was used to analyze the gut microbiota of 35 H. cichorii adults, including wild female adults (WFA), wild male adults (WMA), female adults fed with luffa flowers (LFA), male adults fed with luffa flowers (LMA), female adults fed with artificial diet (AFA), and male adults fed with artificial diet (AMA). The results displayed that the major bacterial phyla present in the gut microbiota of the H. cichorii were Firmicutes, Proteobacteria, Bacteroidetes, Fusobacteria, Teneriicutes, and Actinobacteria. The major bacterial genera were Lactococcus, Lactobacillus, Enterococcus, Ralstonia, Sebaldella, Dysgonomonas, Spiroplasma, Weissella, Klebsiella, and Serratia. Food habits had a significant effect on the diversity and composition of gut microbiota in H. cichorii, whereas gender did not exhibit a remarkable impact on the diversity and composition of gut microbiota. The artificially fed group of H. cichorii had more beneficial microorganisms in the intestine and higher food utilization efficiency. These results provide a basis for subsequent examination of gut microbiota in H. cichorii or other Coleoptera insects, as well as the artificial rearing of blister beetles.
Mesoporous Titania Thin Films‐Gold Nanoparticles Composites: A Comparative Study about the Role of Synthesis Variables on the Catalytic Response
Authors: Borovik Paula F. , Angelomé Paula C. 
Published: January 2025

AbstractIn this work, the preparation of catalysts based on spherical Au nanoparticles and mesoporous TiO2 thin films is presented, along with a systematic analysis of the effect of different synthetic variables on the catalytic activity of the composites. The Au nanoparticles (with diameters around 5 nm) were synthesized by in situ reduction inside the porous structure of amorphous TiO2 films with different pores sizes and pore arrangements. The effect of oxide thermal treatment, pore size, film thickness, and the amount of embedded Au nanoparticles on the catalytic activity was evaluated, using two different model reactions. The obtained results indicate that the proper selection of the oxide thermal treatment is key to obtain stable and durable composites, with a reproducible catalytic performance. Interestingly, several synthetic conditions led to equivalent catalytic activities. In particular, the film thickness and the total amount of Au particles did not significantly affect the reaction constants, indicating that the proportion of particles involved in the catalysis is low. Since the preparation of the composites involves several steps, the fact that such variables have a weak influence on the catalytic activity results very useful in ensuring an easy production of reproducible and active catalysts.
An Audit of Sport Nutrition Services Within Male and Female International Rugby Union: Implications for Research and Practice
Authors: Wilson Lara , Jones Ben , Backhouse Susan H. , Boyd Andy , Costello Nessan 
Published: January 2025

ABSTRACTTo critically evaluate sport nutrition services available to male and female international rugby unions. Fifteen participants, representing 16 international rugby unions, including nine female and seven male teams (one participant worked with both a female and male union), responded to an online survey. Twelve of the unions recruited were ranked in the top 10 globally by World Rugby. Twelve unions employed accredited nutrition practitioners with significant experience (> 5 years: n = 5; > 10 years: n = 4) and advanced qualifications (master's degrees: n = 8; doctorates: n = 2). Three unions did not employ a qualified nutrition practitioner (female: n = 2; male: n = 1). Full‐time employment was more common among nutrition practitioners serving male (n = 4/5) versus female (n = 3/6) unions. Practitioners served male unions for more hours per week (42 ± 28) than female unions (24 ± 20). Practitioners were involved in sport science meetings (n = 14/15), anti‐doping education, menu design, strategy development (n = 13/15), body composition assessments, individual consultations (n = 12/15), focusing on fuelling, recovery and injury rehabilitation (n = 14/15). Participants were “moderately confident” (n = 8/15) in using behaviour change techniques. Most participants agreed on the lack of female‐specific nutrition guidance (n = 14/15), relying on guidance for male players due to limited evidence (n = 7/9). This study provides the first critical reflection of sport nutrition service delivery within international rugby. The findings highlight gender disparities for female players, with reduced applied support and a lack of female‐specific guidelines. Recommendations include enhancing practitioner training in behaviour change, hiring qualified nutritionists, deemphasising body composition assessment, and conducting more research to improve nutrition services, especially for women.
The Psychological, Cognitive, and Behavioural Effects of Starvation in Humans: A Scoping Review
Authors: Spettigue Wendy , Drouin Stéphanie , Isserlin Leanna , Palmert Sasha , Roscoe Clare , Harrison Megan , Kanbur Nuray , Bishop Jacquie , Norris Mark L. 
Published: January 2025

ABSTRACTBackgroundResearch has highlighted the physical complications of starvation, but there is less research examining the psychological effects of starvation in humans.AimsThis scoping review synthesises literature on the non‐physical effects of starvation in humans.MethodFollowing PRISMA‐ScR guidelines, we searched MEDLINE, PsycINFO, and Global Health for studies published between 1946 and 2023 examining the non‐physical effects of starvation in individuals aged 2–79 years, including those who were starved, malnourished, stunted, wasted, underweight, had a restrictive eating disorder, or were raised in famine conditions.ResultsFrom 16,555 abstracts, 851 articles on the effects of malnutrition were reviewed, and 318 were included. Among these, 35% focused on children and adolescents, 25.5% on adults with comorbid illnesses, 17% on older adults, 13% on those with eating disorders, 6% on adults without comorbidities, and 3.5% on famine survivors. Cognitive impairments were the most frequently reported effects in children. In adults and older adults, depression and anxiety were common, along with reduced cognitive functioning, reduced quality of life, social withdrawal, impaired sleep and impaired sexual functioning. Individuals with eating disorders experienced depression, anxiety, obsessive‐compulsive symptoms, emotion regulation difficulties, and cognitive impairment.ConclusionsThere is extensive evidence showing the detrimental non‐physical consequences of starvation in children and adults. These findings should inform research, clinical interventions, and educational materials addressing the effects of insufficient nutrition, including in those with restrictive eating disorders.