bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Fuzzy Synthetic Evaluation Analysis of the Drivers of Urban Expansion on Peri-Urban Lands in Ilorin, Nigeria
Authors: Afolayan John Olayemi , Adebayo Michael Adedayo , Ige Victor Olutope , Afolayan Abel Omoniyi 
Published: October 2023

Aim: To examine the drivers of urban expansion on peri-urban areas in Ilorin, Kwara State, Nigeria.
Study Design: Cross-sectional survey research.
Place and Duration of Study: Eyenkorin, Kwara State 2022.
Methodology: From the literature review, fifteen (15) drivers of urban expansion at the peri-urban areas were highlighted. Afterwards a pilot survey was done on the 15 factors among experts in academia with relevant experiences in the built environment. The 15 factors were affirmed adequate for the study. A structured questionnaire survey on a 4-Point Likert Scale was administered to 332 household heads in the study area to colate opinions on how the highlighted factors influence urban expansion on the peripheral land. Weighted Mean Score, Factor Analysis and Fuzzy Synthetic Evaluation were used to analyze the factors driving urban expansion in the study area. Weighted Mean Score was used to evaluate the individual factors driving urban expansion of peripheral lands in the study area. The Factor Analysis helped to identify the principal individual factors driving urban expansion at the study area and how they are related with to one another. Fuzzy Synthetic matrix was used to reveal the categories of factors driving urban expansion at the study area in order of their importance.
Results: From study, Occupation and living related factors with a criticality index of 3.12 are the most critical drivers of urban expansion towards the periphery in the study area. This is followed by Accessibility comfort and Land speculation factors with a criticality index of 2.96; and Religious and Institutional factors with a criticality index of 2.72. However, in the study area, Socio-Cultural related factors with a criticality index of 1.22 are not significant drivers of urban expansion towards the periphery in the study area.
Conclusion: The study revealed that there has been exponential spatial urban land use expansion in the peripheral area considered for the study. The study revealed that the factors driving urban expansion to the peripheral area centered around job/occupation related factors, housing and living factors, accessibility factors, religious and institutional factors. For the purpose of environmental preservation and a structured land use, attention should be given to the pace and pattern of urban expansion to achieve a sustainable land use. Hence, there is need to start giving attention to how urban expansion occurs and the land use activities that clusters around the landmarks driving the urban expansion at the peri-urban areas in order to ensure sustainable urban expansion especially in developing countries where this can be an oversight. This will help to optimize a balanced urban land use dynamics for the present and the future preservation of the environment.
Effect of Different Farming Types on Growth, Yield and Yield Attributing Parameters of Finger Millet under Finger Millet Based Intercropping Systems
Authors: Nabooji Abdulgani , Veeranna H. K. , Kumar M. Dinesh , Mavarkar Narayana S. , Ganapathi  , Nandish M. S.  
Published: October 2023

A field experiment was conducted on performance of finger millet based inter cropping system under different farming types during kharif 2019-20 and 2020-21 at College of Agriculture, KSN UAHS Shivamogga. The Experiment was laid out with split-plot design having Three farming types as main plots (conventional, organic, and natural farming) and finger millet based inter cropping system as subplots (Finger millet + red gram, finger millet + field bean, Sole finger millet, sole red gram and sole field bean) in three replications. Among different farming types, conventional farming type recorded significantly higher yield parameters viz., number of productive tillers hill-1 (5.14), number of ear heads hill-1(3.83), number of fingers per ear head (6.31), number of grains ear head-1 (4002.50), and test weight (3.71 g) there by achieved significantly higher grain yield (2449.83 kg ha-1) and straw yield (3957.42 kg ha-1) as compared to organic (2039.67 kg ha-1 and 3297.30 kg ha-1) and natural farming (1470.83 kg ha-1and 2328.35 kg ha-1) respectively. Among the finger millet based inter cropping system, the higher grain and straw yield (2225.67 kg ha-1 and 3561.13 kg ha-1) respectively was recorded in sole finger millet as compare to finger millet + redgram (1991.67 kg ha-1 and 3243.17 kg ha-1) respectively and finger millet + field bean (1743.00 kg ha-1 and 2778.77 kg ha-1) respectively. Whereas, the interaction effect between farming types and finger millet based intercropping systems was found non-significant.
Parent-Perceived Benefits and Harms Associated With Internet Use by Adolescent Offspring
Authors: Kimball Harry Graff , Fernandez Francesca , Moskowitz Kathleen Anne , Kang Minji , Alexander Lindsay M. , Conway Kevin P. , Merikangas Kathleen Ries , Salum Giovanni Abrahão , Milham Michael Peter 
Published: October 2023

ImportanceLimited systematic information on familial factors and perception of the benefits and harms of internet use by youths is available. Much of the current research has been hampered by small nondiverse samples and limited information on key familial and offspring characteristics.ObjectiveTo characterize parental perceptions and concerns about internet use associated with adolescent development, well-being, safety, family connectedness, and potential for problematic internet use.Design, Setting, and ParticipantsA 20-minute, English-language survey was developed with expert stakeholders using previously validated questionnaires and was conducted online between June 17 and July 5, 2022. Participants included 1005 parents of children and adolescents aged 9 to 15 years drawn from an online digital survey platform and calibrated for representation with post hoc weightings.Main Outcomes and MeasuresParent survey responses about family characteristics and internet use were used to compute Internet Addiction Test scores for parents and their offspring, Alabama Parenting Questionnaire scores, and an aggregate family connectedness score.ResultsThe survey cohort of 1005 parents included 568 women (56.5%) and 437 men (43.5%) with a mean age (SD) of 39.5 (6.4) years. In terms of race and ethnicity, the most common categories included Black or African American (95 [9.5%]), Latinx or Hispanic (100 [10.0%]), White (602 [59.9%]), and 2 or more races or ethnicities (122 [12.1%]). Respondents endorsed parental concerns that included exposure to harmful content (646 [64.3%]) and online bullying (533 [53.0%]). Two hundred twenty-five parents (22.4%) had specific concerns about internet addiction in their adolescent offspring, and twice as many parents reported specific concerns about internet addiction than substance addiction. However, parents also indicated that internet use improved family connectedness among immediate families (468 [46.6%]) and extended families (568 [56.5%]). Internet Addiction Test scores in adolescent offspring were correlated with parent scores (β = 0.62 [SE = 0.02]; P &amp;lt; .001) and Alabama Parenting Questionnaire-Inconsistent Discipline scores (β = 0.23 [SE = 0.11]; P = .04).Conclusions and RelevanceIn this survey study of parent perceptions of internet use among adolescent offspring, parents believed the internet brought families closer yet also expressed concerns. Problematic internet use among youths was correlated with negative parenting styles and parent internet use. This research adds to the literature by suggesting that families, their communities, and industry may have common ground to collaborate on reducing the negative effects of internet use.
Treatments During Pregnancy Targeting ERBB2 and Outcomes of Pregnant Individuals and Newborns
Authors: Gougis Paul , Grandal Beatriz , Jochum Floriane , Bihan Kevin , Coussy Florence , Barraud Solenn , Asselain Bernard , Dumas Elise , Sebbag Clara , Hotton Judicael , Spaggiari Emmanuel , Pierga Jean-Yves , Savarino Raphaëlle , Laas Enora , Spano Jean-Philippe , Reyal Fabien , Hamy Anne-Sophie 
Published: October 2023

ImportanceTargeted therapies directed against ERBB2 are the cornerstone of medical treatment for ERBB2-positive breast cancers but are contraindicated during pregnancy.ObjectivesTo describe the association of exposure to anti-ERBB2 agents during pregnancy with pregnancy and fetal or newborn outcomes, and to compare the risk and types of adverse outcomes reported more frequently in this context than after exposure to other anticancer agents.Design, Setting, and ParticipantsFor this case-control study, All reports with a pregnancy-related condition and an antineoplastic agent (Anatomical Therapeutic Chemical classification group L01) registered in the World Health Organization international pharmacovigilance database VigiBase up to June 26, 2022, were extracted. All reports with a pregnancy, an antineoplastic treatment during pregnancy, and a cancer were retained. Reports with anticancer agents prescribed for nononcologic purposes were not included.ExposureThe exposure group was defined as reports that mention anti-ERBB2 agents compared with exposure to other anticancer agents.Main Outcome and MeasuresThe main outcome was the reporting odds ratio (ROR) for maternofetal complications in the group exposed to anti-ERBB2 agents compared with other anticancer agents, as determined using a disproportionality analysis.ResultsA total of 3558 reports (anti-ERBB2 agents, 328; other anticancer agents, 3230) were included in the analysis. In the group exposed to anti-ERBB2 agents, most reports were from the US (159 [48.5%]), the mean (SD) age of participants was 30.8 (10.4) years, and 209 patients (97.7%) were treated for breast cancers. The molecules most frequently involved in cases with anti-ERBB2 agents were trastuzumab (n = 302), pertuzumab (n = 55), trastuzumab-emtansine (n = 20), and lapatinib (n = 18). The outcomes overreported in these cases included oligohydramnios (ROR, 17.68 [95% CI, 12.26-25.52]; P &amp;lt; .001), congenital respiratory tract disorders (ROR, 9.98 [95% CI, 2.88-34.67]; P &amp;lt; .001), and neonatal kidney failure (ROR, 9.15 [95% CI, 4.62-18.12]; P &amp;lt; .001). Sensitivity and multivariable analyses found similar results. Toxic effects were also significantly overreported for trastuzumab-emtansine (cardiovascular malformation: ROR, 4.46 [95% CI, 1.02-19.52]) and lapatinib (intrauterine growth restriction: ROR, 7.68 [95% CI, 3.01-19.59]).Conclusions and RelevanceIn this case-control study of 328 individuals exposed to anti-ERBB2 agents during pregnancy, exposure was associated with a severe specific adverse pregnancy and fetal or newborn outcomes compared with exposure to other anticancer treatments.
Critique of a measure of interrogative suggestibility for children: The Bonn test of statement suggestibility
Authors: Rowsell Kathryn , Colloff Melissa F. 
Published: October 2023

AbstractProfessionals supporting child witnesses are concerned with susceptibility to suggestion, that is, the impact of suggestive questioning on the information that children report. The Bonn test of statement suggestibility (BTSS; Endres, The Journal of Credibility Assessment and Witness Psychology, 1997, 1, 44–67; Endres et al., Psychologie der zeugenaussage, 1998) is a measure of interrogative suggestibility. It focuses on the interaction between the individual child and their environment, which may make a child vulnerable to suggestion. We aim to examine the psychometric properties of the BTSS tool by critiquing the scientific construction of the elements and the robustness of the measure. We conclude that the limited available research allows for a tentative conclusion of suitable levels of reliability and validity. However, we propose that the BTSS should not be administered in isolation to determine suggestibility but instead there should be a wider assessment completed with consideration of the broader aspects of the child's individual situation.
PiezoClimber: Versatile and Self‐Transitional Climbing Soft Robot with Bioinspired Highly Directional Footpads
Authors: Zheng Mingjie , Wang Dongkai , Zhu Dekuan , Cao Shuhong , Wang Xiaohao , Zhang Min 
Published: October 2023

AbstractThe ability to climb is crucial for terrestrial robots to expand their scope of application with improved navigation capacity. While some soft climbing devices are available, they often lack versatility when it comes to adapting to rough surfaces and changes in terrains. In this regard, a piezo‐based soft robot with bioinspired footpads has been developed that can deliver superior climbing performance. Through their unprecedented directional friction, these footpads enable the robot to complete rigorous climbing tasks on surfaces with a climbing angle of 0–180° and a variety of roughness from ultra‐smooth to millimeter‐scale. With a unique slide‐swing gait, the robot is able to complete fast climbing on a 90° substrate at a speed of 1.4 body lengths per second (BL/s) and self‐transitional climbing on surfaces with a roughness difference of 11 µm and an angle change of 60° in 5 s without active control. A scaled down version of this climber is also presented with increased mobility to traverse steps of 3 body heights and slits of 0.75 BH effectively. In summary, the development of this soft robot with highly directional footpads paves the way for soft robots to navigate varied surfaces and ascend challenging terrains with improved mobility.
Ru Cluster Incorporated NiMoO(P)4 Nanosheet Arrays as High‐Efficient Bifunctional Catalyst for Wind/Solar‐To‐Hydrogen Generation Systems
Authors: Wu Shengye , Chen Ding , Li Shang , Zeng Yuting , Wang Tao , Zhang Jian , Yu Jun , Mu Shichun , Tang Haolin 
Published: October 2023

AbstractDeveloping cost‐efficient bifunctional water splitting catalysts is crucial for sustainable hydrogen energy applications. Herein, ruthenium (Ru)‐incorporated and phosphorus (P)‐doped nickel molybdate (Ru‐NiMoO(P)4) nanosheet array catalysts are synthesized. Due to the synergy of Ru clusters and NiMoO(P)4 by the modulated electronic structure and the rich active sites, impressively, Ru‐NiMoO(P)4 exhibits superior OER (194 mV @ 50 mA cm−2) and HER (24 mV @ 10 mA cm−2) activity in alkaline media, far exceeding that of commercial Pt/C and RuO2 catalysts. Meanwhile, as bifunctional catalyst, to drive the overall water splitting at the current density of 10 mA cm−2, Ru‐NiMoO(P)4 requires only 1.45 V and maintaining stable output for 100 h. Furthermore, Ru‐NiMoO(P)4 also possesses excellent capability for seawater electrolysis hydrogen production. Moreover, the successful demonstration of wind and solar hydrogen production systems provide the feasibility of the ultra‐low Ru loading catalyst for large‐scale hydrogen production in the future.
Unloading‐Induced Skeletal Interoception Alters Hypothalamic Signaling to Promote Bone Loss and Fat Metabolism
Authors: Guo Qiaoyue , Chen Ningrong , Patel Kalp , Wan Mei , Zheng Junying , Cao Xu 
Published: October 2023

AbstractMicrogravity is the primary factor that affects human physiology in spaceflight, particularly bone loss and disturbances of the central nervous system. However, little is known about the cellular and molecular mechanisms of these effects. Here, it is reported that in mice hindlimb unloading stimulates expression of neuropeptide Y (NPY) and tyrosine hydroxylase (TH) in the hypothalamus, resulting in bone loss and altered fat metabolism. Enhanced expression of TH and NPY in the hypothalamus occurs downstream of a reduced prostaglandin E2 (PGE2)‐mediated ascending interoceptive signaling of the skeletal interoception. Sympathetic antagonist propranolol or deletion of Adrb2 in osteocytes rescue bone loss in the unloading model. Moreover, depletion of TH+ sympathetic nerves or inhibition of norepinephrine release ameliorated bone resorption. Stereotactic inhibition of NPY expression in the hypothalamic neurons reduces the food intake with altered energy expenditure with a limited effect on bone, indicating hypothalamic neuroendocrine factor NPY in the facilitation of bone formation by sympathetic TH activity. These findings suggest that reduced PGE2‐mediated interoceptive signaling in response to microgravity or unloading has impacts on the skeletal and central nervous systems that are reciprocally regulated.
Visible Light‐Promoted Three‐Component Reaction for the Synthesis of Fluoroalkyl‐Substituted Amides from Isocyanides
Authors: Cui Mengxing , Wang He , Chen Yang , Wang Xin , Sun Ran , Zhou Ming‐Dong , Li Lei 
Published: October 2023

AbstractA visible‐light‐promoted radical fluoroalkylation has been achieved through a three‐component reaction of fluoroalkyl reagents, isocyanides and water, affording fluoroalkyl‐substituted amides in good yields. This reaction involves the generation of the nitrilium cation by single‐electron reduction of the imidoyl radical and a subsequent nucleophilic attack by water. Mechanistic studies support the generation of the imidoyl radical through the capture of the fluoroalkyl‐substituted imidoyl radical species.
Precision medicine analysis of heterogeneity in individual‐level treatment response to amyloid beta removal in early Alzheimer's disease
Authors: Pang Menglan , Gabelle Audrey , Saha‐Chaudhuri Paramita , Huijbers Willem , Gafson Arie , Matthews Paul M. , Tian Lu , Rubino Ivana , Hughes Richard , de Moor Carl , Belachew Shibeshih , Shen Changyu 
Published: October 2023

AbstractINTRODUCTIONAlzheimer's disease (AD) is a neurological disorder with variability in pathology and clinical progression. AD patients may differ in individual‐level benefit from amyloid beta removal therapy.METHODSRandom forest models were applied to the EMERGE trial to create an individual‐level treatment response (ITR) score which represents individual‐level benefit of high‐dose aducanumab relative to the placebo. This ITR score was used to test the existence of heterogeneity in treatment effect (HTE).RESULTSWe found statistical evidence of HTE in the Clinical Dementia Rating–Sum of Boxes (CDR‐SB;P = 0.034). The observed CDR‐SB benefit was 0.79 points greater in the group with the top 25% of ITR score compared to the remaining 75% (P = 0.020). Of note, the highest treatment responders had lower hippocampal volume, higher plasma phosphorylated tau 181 and a shorter duration of clinical AD at baseline.DISCUSSIONThis ITR analysis provides a proof of concept for precision medicine in future AD research and drug development.Highlights
Emerging trials have shown a population‐level benefit from amyloid beta (Aβ) removal in slowing cognitive decline in early Alzheimer's disease (AD).
This work demonstrates significant heterogeneity of individual‐level treatment effect of aducanumab in early AD.
The greatest clinical responders to Aβ removal therapy have a pattern of more severe neurodegenerative process.
Implementation of a Colorectal Surgical Site Infection Prevention Bundle and Checklist: A Quality Improvement Project
Authors: White Carrie , Kurtz Sarah , Lusk Leandra , Wilson Brigitte , Britton Vickie , Hayden Karen , Hunt Sarah , Hyland Jennifer , Kittrell William , Maddox Jason , Tanner Ashley , Tucker Valerie 
Published: October 2023

ABSTRACTAfter noting an elevated surgical site infection rate in 2019 associated with colorectal surgeries, leaders at two Central Virginia health system hospitals convened an interdisciplinary team to audit current practices and research infection prevention strategies. After identifying a lack of standardization in care processes for colorectal surgery patients and reviewing the literature on colorectal bundles, the team created a bundle focusing on the use of antibiotics, chlorhexidine gluconate wipes or baths, separate closing instrument trays, nasal decolonization, bowel preparation, and maintaining patient normothermia. After synthesis and stakeholder input, the team implemented the colorectal bundle along with a checklist for all users to complete to ensure compliance and standardization of practice and for auditing purposes. Implementation results were positive: the total number of colorectal infections decreased from nine in 2020 to three in 2021. Education was critical to securing staff member engagement for successful implementation of and compliance with the bundle.
Clinical Issues — November 2023
Authors: Seeman Kristyn 
Published: October 2023

THIS MONTH
Securing sterile drapes with skin staples
Key words: sterile drapes, manufacturer's instructions for use, skin stapler, skin integrity, puncture wound.
Sterility of rubber stoppers on medication vials
Key words: rubber stopper, medication vial, alcohol swab, dust cover, contamination.
Social media use in the OR
Key words: social media, distractions, personal electronic device, Health Insurance Portability and Accountability Act (HIPAA), liability.
Staffing for local‐only anesthesia procedures
Key words: staffing, RN circulator, patient acuity, monitoring, local anesthetic systemic toxicity (LAST).
Exploring the Versatility of the Amidation of Aryl Acid Fluorides using the Germylamines R3GeNMe2
Authors: Fortney Vanessa A. , Murphy Julia K. , Stancil Thad R. , Gembicky Milan , Rheingold Arnold L. , Weinert Charles S. 
Published: October 2023

AbstractThe formation of amide bonds is an important process since this linkage is an essential component in proteins, pharmaceuticals, and other medicinally and biologically significant molecules. Recently, it was demonstrated that germylamines R3GeNR’2 were useful reagents for the conversion of acid fluorides to amides. This transformation occurs readily at room temperature and has a low activation energy. In the present study, the versatility of this amidation reaction with aryl acid fluorides is investigated. A series of thirteen acid fluorides with various substituents on the aromatic ring were reacted with the germylamine Ph3GeNMe2 and twelve of these were converted to the corresponding amides in high yields, the exception being 1,4‐benzenedicarbonyl difluoride. The germylamines Bun3GeNMe2 and Pri3GeNMe2 also could be used for this interconversion, and both of these species successfully converted 1,4‐benzenedicarbonyl difluoride to the corresponding amide. In addition, the crystal structure of Ph3GeNMe2 is reported. This represents one of only three crystallographically characterized germylamines. The synthesis and 19F NMR characterization of three fluorogermanes R3GeF (R=Bun, Pri, and Mes) are also reported herein.
The educational experience of young people in residential care through the lens of learning careers
Authors: Marion Élodie , Tchuindibi Laurence 
Published: October 2023

AbstractTo complement previous research investigating the educational attainment of young people in out‐of‐home care reporting lower educational outcomes and risk factors, a more comprehensive approach is necessary. Our objective with this article is to better understand the learning careers of young people in residential care. That includes documenting their experience and the meaning they attribute to learning in formal settings over time and identifying critical turning points in each young person's learning career. Based on an interpretative paradigm, we conducted a qualitative study using biographical interviews with young people aged 14–18 in residential care in Quebec, Canada. We first demonstrate that the learning careers of young people in residential care are unique and non‐linear. Second, by studying turning points, we highlight the critical role that institutions, teachers and youth workers can play in fostering a positive or negative learning career. Finally, we noted learners’ different responses to these circumstances and differences in learners’ perception of their measured performance and their influence on their engagement with formal learning. We discuss why considering young people as the main actors and producers of meaning regarding their educational experience and learning careers appears necessary.