bluuebunny/crossref_metadata_2025_split huggingface dataset:
Docking study and molecular dynamic approach to predicting the activity of 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid against COX-1 enzyme
Authors: Tasha Rossa Auli , Ekowati Juni , Suzana  , Maulana Saipul 
Published: October 2023

Background: Ferulic acid is a phenolic acid compound that has anti-inflammatory and anti-thrombosis activity. However, ferulic acid has the disadvantage of poor absorption. Structural modifications can be made to increase the biological activity of the compound. In this research, the structure of ferulic acid was modified into 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid.
Objective: The purpose of this research is to predict the activity of 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid.
Method: It was carried out using the Pass Online Prediction, Autodock 1.5.7, Discovery Studio and Maestro Schrödinger 2020-1 software.
Result: The activity prediction results showed that 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid had anti-inflammatory and anti-thrombotic activity. The molecular docking results showed that 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid had lower free bond energy values than ferulic acid, hence, predicted to have greater activity. Molecular dynamics also reveal better stability interactions of the 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid with COX-1 protein than the ferulic acid.
Conclusion: The compund, 4-(4-methoxy)benzoyloxy-3-methoxycinnamic acid is feasible to be synthesised.
An assessment of platelet response to ticagrelor in post-percutaneous coronary intervention patients using light transmission platelet aggregometry (LTA)
Authors: Zulkarnain Bambang Subakti , Samlan Karima , Khotib Junaidi , Yogiarto Muhammad , Aminuddin Muhammad , Fatmawati Umi 
Published: October 2023

Background: Low on-treatment platelet reactivity (LTPR) or High on-treatment platelet reactivity (HTPR) with P2Y12 inhibitors is associated with bleeding (LTPR) or ischemic events (HTPR) in patients on dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI).
Objective: Mapping of Indonesian patients’ platelet response secondary to ticagrelor and thus identifying either LTPR or HTPR.
Method: During May – June 2019, 20 post-PCI patients on aspirin–ticagrelor combination were included. Light transmission aggregometry (LTA) for monitoring platelet function was used. Ticagrelor’s LTA <40% is LTPR while >70% is HTPR.
Result: Patients were mostly male (18 patients) and aged between 40-73 years old with a history of diabetes and/or hypertension and smoking. About eight patients (40%) were LTPR and one (5%) patient was HTPR.
Conclusion: A personalised DAPT strategy for preventing bleeding events, a de-escalation, might be valuable for Indonesian patients.
The risk of combined use of herbal and conventional medicines in diabetic patients
Authors: Rahem Abdul , Athiyah Umi , Setiawan Catur Dian , Hermansyah Andi 
Published: October 2023

Background: The prevalence of diabetes mellitus (DM) continues to increase due to changes in human lifestyle. Adherence to taking medication becomes one of the keys to successful blood glucose control. Unfortunately, not all people with DM are obedient to take medicine because of various reasons, such as fear of the side effects. To avoid some concerns about medicine, some prefer to add herbal medicine.
Objective: This study determined whether the addition of herbal medicine to conventional drugs increases the incidence of hypoglycemia.
Methods: This study was carried out from October 2019-March 2020 on 350 Madurese patients with DM in 33 primary healthcare centres of Madura. Data were collected using a valid and reliable questionnaire. The independent variable in this study was the use of herbal medicine, while the dependent variable was the incidence of hypoglycemia.
Results: About 41.4% of respondents used herbal medicine in addition to conventional drugs. Among those who consumed herbal medicine, 59.3% experienced hypoglycemia, while 24.4% did not take herbal medicine. The results showed a significant relationship between the use of herbal medicine and the incidence of hypoglycemia with a p-value of 0.0001.
Conclusion: The use of herbal medicine increased the incidence of hypoglycemia.
Assessment of community-based sanitation management in coastal areas from an economic and financial perspective
Authors: Susilawati  , Harahap R. Hamdani , Mulya Miswar Budi , Andayani Lita Sri , Falefi Reinpal 
Published: October 2023

Background: Community-Based Sanitation Management (CBSM) in coastal areas requires motivation and support from various stakeholders.
Objective: To analyse the level of CBSM based on the socio-economic status of the community and its constraints.
Method: A cross-sectional study was conducted in the subdistrict of Deli Serdang, North Sumatra, Indonesia with a sample size of 414 households. The outcome measured in this study is the economic impact on CBSM. Data analysis was performed using the Kruskal-Wallis test with variable tests of economics and the level of CBSM.
Result: Most communities living in coastal settlements have inadequate sanitation knowledge and skills, which poses an inhibiting factor for management.
Conclusion: Community participation in sanitation management in coastal areas is significantly low (low=27.7%, medium=65.0%). Therefore, support from stakeholders is needed. This study recommends that early and continuous education alongside training is required to increase knowledge on clean, healthy, and sustainable sanitation management.
Medication complexity and COVID-19 pandemic impact on the cost burden in non-COVID elderly patients at the emergency department
Authors: Hamidah Khusnul Fitri , Rahmadi Mahardian , Abdissalam Erfan , Septiani Indah , Utomo Febriansyah Nur , Batubara Wieka Rafelina 
Published: October 2023

Background: The global increase in the elderly population and the incidence of emergency conditions due to physiological changes pose cost challenges for emergency services. COVID-19 potentially affects the financial burden of medication in elderly patients.
Objective: To analyse the impact of medication complexity on the cost burden in elderly patients admitted to the Emergency Department (ED) before and during the COVID-19 pandemic.
Method: A retrospective observational study was conducted among elderly patients (aged > 60 years) who visited ED but were not hospitalised between January to April 2020. The medication complexity was measured using the Medication Regimen Complexity Index (MRCI) while the cost was collected from the hospital information system.
Result: A total of 321 ED visits were included in this study. The results showed that the mean of the total medication was 3.89 ± 1.70, while the mean score of the MRCI was 15.20 ± 6.54. The mean medication cost required was IDR 56,342 for each ED visit.
Conclusion: This study provided an overview and input to control medication costs for elderly patients in the emergency setting. Interested parties can design policies that are beneficial in economics and therapeutic outcomes.
The activity of bioactive compounds from bidara upas (Merremia mammosa (Lour) Hall. f.) as an inhibitor of SARS-CoV2 entry stage: In silico study
Authors: Purwitasari Neny , Agil Mangestuti , Siswodihardjo Siswandono , Maulana Saipul , Zubair Muhammad Sulaiman 
Published: October 2023

Background: Covid 19 is a global pandemic caused by SARS-CoV2, a novel coronavirus. This virus enters target organ epithelial cells by utilising two host proteins; Transmembrane Serine Protease 2 (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2). The inhibition of TMPRSS2 has shown to be a promising means to prevent viral infection. Molecular docking, and Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis will determine the activity of Merremia mammosa (Lour) Hall.f. secondary metabolites against the TMPRSS2 of SARS-CoV2.
Objective: This study aimed to investigate the in silico activity of Merremia mammosa (Lour) Hall.f. active compounds against TMPRSS2 of SARS-CoV2.
Method: Molecular docking was performed on 206 compounds obtained through metabolite profiling from a previous study on the SARS-CoV TMPRSS-2 protein (PDB id.7MEQ) using the Maestro Schrodinger software.
Result: The results indicated there were 6 compounds (three of which were flavonoids: cynarine, phellodensin F, and gemixanthone A) with docking scores lower than standard drugs (nafamostat as a native ligand). ADMET analysis revealed that among 6 compounds, cynarine has the highest drug-likeness and the greatest inhibitory potential against TMPRSS2.
Conclusion: Cynarine was found to be active and promising to be developed as an inhibitor of the SARS-CoV2 entry step.
Perception of healthcare personnel in interprofessional collaborations: A study in two “type c” hospitals in East Java
Authors: Wahyuni Khurin In , Nita Yunita , Zairina Elida 
Published: October 2023

Background: The World Health Organization (WHO) describes Interprofessional Collaboration (IPC) as a comprehensive service provided by several health workers from different professional backgrounds, collaborating with patients, families and communities to provide quality services.
Objective: To investigate the relationship between professions, gender, length of employment and age with IPC.
Method: A cross-sectional study was conducted in two type C hospitals in East Java from June to July, 2022. The total sampling technique used involved doctors, pharmacists, nurses and nutritionists. Informed consent was given to all study participants. The Collaborative Practice Assessment Tool (CPAT) questionnaire used a five-point Likert scale which comprising eight domains.
Results: From the lowest average results for each domain, significant differences were found in the education group with the domain "team relations with the community, namely the pharmacist profession".
Conclusion: Doctors, pharmacists, nurses and nutritionists have different levels of IPC perception in eight domains but there were no significant differences.
Factors that contribute to blood sugar control in type 2 diabetes mellitus
Authors: Achmad Gusti Noorrizka Veronika , Yufria Lea Nanda , Rahem Abdul , Pristianty Liza 
Published: October 2023

Background: Diabetes needs to be well controlled so as not to cause acute and chronic complications. Therefore, it is necessary to comply with regimen therapy and control diet and physical exercise.
Objective: This study aimed to assess the contribution of medication adherence and nonpharmacological therapy adherence, as well as other factors affecting blood sugar control.
Method: This study involved 76 type 2 diabetic patients from a Community Health Center in East Surabaya. Medication adherence was measured with an ARMS questionnaire and pill count, while nonpharmacological therapy was measured with a self-developed questionnaire.
Result: The majority of respondents have uncontrolled blood sugar levels, were not compliant with treatment both as measured by ARMS and by the pill count method, and are not compliant with nonpharmacological therapy with the following frequencies: 85.5% (n=65), 92.1% (n=70), 57.9% (n=44), 98.7% (n=75). The results of multiple correlation tests showed that age, duration of treatment, adherence to treatment with the ARMS method and the pill count method, and adherence to nonpharmacological therapy simultaneously affected blood sugar control by 72.7%.
Conclusion: Factors that simultaneously determine poor blood sugar control are age, duration of diabetes therapy, non-adherence to treatment, and non-adherence to nonpharmacological therapy.
Chemoinformatics approach to the screening and development of quassinoids from Brucea javanica as antituberculosis drugs
Authors: Nurhan Ahmad Dzulfikri , Sulistyowaty Melanny Ika , Ekowati Juni 
Published: October 2023

Background: The morbidity and mortality of tuberculosis (TB) remain high in various countries as a result of pharmacological intervention failures, such as incomplete treatment regimens and inadequate doses, triggering resistance of Mycobacterium tuberculosis strains to anti-TB drugs used. This phenomenon requires innovation to explore and develop novel anti-TB drugs so that the problem of resistance is overcome and treatment of TB is more optimal.
Objective: In this study, chemoinformatics investigations were carried out on quassinoids derived from Brucea javanica to be developed as anti-TB drugs.
Method: Evaluation of drug-likeness with the SwissADME online tool, prediction of toxicity with the pkCSM online tool, and molecular docking studies with AutoDock Vina software were performed on 18 quassinoids from Brucea javanica.
Result: The findings showed that Bruceine A, Bruceine, and Bruceine D, met the drug-likeness criteria, showed a good toxicity profile, and had better binding energy (-7.5; -7.5; and -7 kcal/mol, respectively) than isoniazid (-5.8 kcal/mol) which is a first-line anti-TB drug on enoyl acyl carrier protein reductase (InhA; PDB ID: 2NSD).
Conclusion: This study found several quassinoids from Brucea javanica with the potential to be developed as anti-TB drugs.
Patient’s perception of the image of community pharmacists
Authors: Ismail Hasan , Athijah Umi , Hidayat Widi , Rahem Abdul 
Published: October 2023

Background: Patients' understanding of the pharmacists’ role is needed to create a positive image so that it is easier for pharmacists to make patients understand the use of drugs.
Objective: This study aimed to assess the public perception of the image of pharmacists in providing services to patients.
Method: An observational study was conducted on fifty-three (53) respondents who received pharmaceutical services directly from pharmacists at the pharmacies in East Java. The research variable was the pharmacists' image which is measured through competence, ethics, communication skills, and emotional intelligence based on the perception of the patient.
Result: The majority of pharmacists had good ratings for their competence and ethics (96%), and most of the pharmacists were perceived to have good communication skills and emotional intelligence (92% and 79% respectively).
Conclusion: The pharmacists' images, according to the patients' perception were in the “good” category, although there is a need to be an increase in emotional intelligence.
Pregnant women behaviours in early detection of preeclampsia warning signs based on health belief model: A structural equal modelling analysis
Authors: Santi Dwi Rukma , Suminar Dewi Retno , Devy Shrimarti Rukmini , Mahmudah  
Published: October 2023

Background: Preeclampsia is a pregnancy complication that frequently arises during the second trimester, typically after 20 weeks of pregnancy, requiring increased awareness and vigilance.
Objective: The aim of this study was to analyse factors affecting pregnant women’s behaviours in early detection of warning signs of preeclampsia (PE) based on the health belief model.
Method: A cross-sectional study was conducted, with 225 respondents as research subjects in Tuban Regency. The sampling technique used was stratified random sampling. Data analysis employed structural equal modelling.
Results: The results demonstrated that sociodemographic factors had an indirect pathway toward detection behaviours of the PE warning signs through perceived susceptibility/severity and perceived barrier. Health belief factors, including perceived susceptibility/severity, perceived threat, perceived benefit, perceived barrier, and perceived self-efficacy, had direct pathways toward detection behaviours of the PE warning signs. Cues to action had both direct and indirect pathways toward detection behaviours of the PE warning signs.
Conclusion: Improvement of promotion efforts and comprehensive health education by incorporating cognitive, physiological, and psychosocial beliefs were immensely required to enhance better detection behaviours.
Conectividade e funções neurais da amígdala no transtorno do espectro autista
Authors: Cruz Gleide Neves , Silva André Ribeiro da , Barros Jônatas de França , Soares Jitone Leônidas , Hora Verônica Santos da , Ferreira Vânia Maria Moraes 
Published: October 2023

A amígdala é uma estrutura do cérebro que desempenha um papel importante na regulação emocional e social. Em indivíduos com transtorno do espectro autista (TEA), a amígdala pode ter algumas diferenças estruturais e funcionais em comparação com indivíduos neurotípicos. O objetivo do estudo foi reunir os aspectos do conhecimento atual sobre as diferenças morfológicas e funcionais da amígdala associadas às alterações neurofuncionais que afetam a cognição das pessoas no TEA. Foi feita uma revisão integrativa da literatura, a partir de 9 artigos publicados nas bases da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Biblioteca Eletrônica Científica Online (SCIELO), National Library of Medicine (PubMed) e The Association for Child and Adolescent Mental Health (Mental Health) a partir de pesquisas realizadas entre 2016 a 2022. As pesquisas sugerem que a amígdala em autistas pode estar hiperativa em situações sociais, o que pode levar a uma maior ansiedade e dificuldades na interação social. Além disso, a amígdala pode estar menos conectada com outras regiões do cérebro que estão envolvidas na compreensão de emoções e processamento social. Essas diferenças na função da amígdala podem contribuir muito para as características do autismo, incluindo dificuldades na comunicação social e interação, bem como comportamentos repetitivos e restritivos. No entanto, mais pesquisas são necessárias para entender completamente como a função da amígdala está relacionada com o autismo e como essas diferenças podem ser tratadas, planejadas e implementadas pelos profissionais da saúde e educação de forma eficaz.
Aspek Hukum Surat Tanda Nomor Kendaraan Yang Pajaknya Telah Habis Masa Berlaku Saat Dilakukan Pemeriksaan Oleh Polisi Lalu Lintas
Authors: Abrahamsz Patricia Julia 
Published: October 2023

Introduction: The ticket is a fine imposed by the police on road users who violate the regulation. Vehicle registration certificate or STNK for short, is proof of registration and ratification of a motorized vehicle based on its registered identity and ownership. Motor Vehicle Tax is a tax levied on ownership and/or ownership of motorized vehicles.
Purposes of the Research: The traffic police have the authority to provide evidence of violations (tickets) in the form of confiscating vehicle registration certificates during motor vehicle inspections. What legal policy is followed by motor vehicle users whose Vehicle Registration Certificate has expired.
Methods of the Research: This study clearly includes normative legal with secondary data. The main problem in this study obviously is achieved by using a juridical-normative approach.
Results Originality of the Research: The results of this study were the police have the authority in terms of traffic violations such as vehicle registration tickets whose taxes have expired. All regulations regarding vehicle registration tickets by the police are regulated in the Traffic and Road Transport Law, Law no. 2 of 2002 concerning the Indonesian National Police and Government Regulation No. 80 of 2012 concerning Procedures for Inspection of Motorized Vehicles on the Road and Enforcement of Traffic and Road Transportation Violations. Legal policies that can be carried out include preventive measures that carry out traffic regulation, conduct traffic control, socialize to the public to comply with traffic regulations, increase the number of police facilities and increase patrol escort activities, especially in vulnerable and vulnerable areas. Meanwhile, for repressive efforts, namely by issuing ticket and reprimand.
Kebijakan Penanggulangan Prostitusi Online Melalui Media Sosial
Authors: Samusamu Roygers , Pasalbessy Jhon Dirk , Adam Sherly 
Published: October 2023

Introduction: The existence of a criminal law policy in an effort to combat online prostitution cannot be separated from the existence of cases of online prostitution in Indonesia.
Purposes of the Research: The current positive law regulations have not been able to tackle the crime of online prostitution through social media in Indonesia. So it needs to be reviewed in formulating criminal provisions relating to online prostitution to create a better arrangement in the future.
Methods of the Research: Type of research: normative juridical, the approach used is the statute approach, the conceptual approach, and the case approach. The sources of legal materials used are Primary Legal Materials, Secondary Legal Materials and Tertiary Legal Materials. The technique for reviewing and collecting primary, secondary and tertiary legal materials is to use documentation studies. The data analysis used in normative legal research is qualitative analysis
Results of the Research: Based on the results of the study, it was found that the concept of online prostitution prevention policies through social media can be overcome with feminist policies so that they can position women according to conditions with criminalization, legalization and decriminalization approaches by eliminating criminal acts of online prostitution through social media based on the socio-cultural background of the Indonesian people and state, while other approaches can also be considered as a policy concept for overcoming the crime of online prostitution through social media. The policy of overcoming the crime of online prostitution through social media has been integrated with criminal law because online prostitution through social media can be handled using criminal law outside the Criminal Code which has a special nature, namely Law Number 21 of 2007 concerning the eradication of criminal acts of trafficking in persons. the shortcomings of the Criminal Code, therefore in an effort to overcome the crime of online prostitution, policies are needed that can provide guarantees and protection to women as perpetrators of online prostitution with various policies and approaches born from socio-cultural values.
Kesesuaian Putusan Pengadilan Agama Ambon Nomor 220/Pdt.G/2021/Pa.Ab Tentang Izin Berpoligami
Authors: Hart Iftin Yuninda , Angga La Ode , Fataruba Sabri 
Published: October 2023

Introduction: The Marriage Law adheres to the principle of monogamy because the law and religion of the person concerned allows it, a husband can have more than one wife if he meets the requirements.Purposes of the Research: To review the Ambon Religious Court through its decision Number 220/Pdt.G/2021/PA.Ab has given permission to the applicant to carry out polygamy without fulfilling the provisions contained in the Law.Methods of the Research: The writing method is normative juridical, with three approaches, namely the conceptual approach, the statutory approach and the case approach.Results of the Research: The results of this research show that the decision of the Ambon Religious Court Number 220/Pdt.G/2021/PA.Ab which has given permission to the applicant to practice polygamy is contrary to Article 4 paragraph 2 of the Marriage Law.