bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing for everyone: can the principles of dementia-friendly design inform design for neurodiversity in health-care settings?
Authors: Waller Sarah , Evans Simon Chester , Bray Jennifer , Atkinson Teresa 
Published: January 2024

Purpose
There is increasing interest in the UK in developing environments that support people who are neurodiverse. This paper aims to report on a project to develop a cognitively supportive environmental assessment tool to improve the design of health centres, where the majority of National Health Service consultations take place, for all users, including people living with dementia and those who are neurodiverse.

Design/methodology/approach
A three-stage process was used: a literature review; the development of a matrix of key design features for people living with dementia, autism and other neurodiverse conditions; and the development of an environmental assessment tool and guide for users, which included easy-to-read versions to maximise service user involvement.

Findings
The overarching concepts of dementia-friendly design can be adapted to create designs for everyone, including those who are neurodiverse.

Research limitations/implications
There is a paucity of research in environmental design for primary care from the patient’s perspective, and, more generally, further research on design for adults with learning disabilities and autism is needed.

Practical implications
The tools are free to download. With adaptation, they have potential applicability across health and care settings.

Originality/value
This project has confirmed that the principles of dementia-friendly design are applicable, with modifications, to a wider group of neurodiverse people. Critically, each person’s response to sensory stimuli is individual rather than determined by their condition.
Homecare nursing: a survey of citizen experiences with health-care professionals in the time allotted for homecare
Authors: Dürr Dorte Wiwe , Mikkelsen Linda Hindsgaul , Moth Grete 
Published: January 2024

Purpose
Research-based knowledge on homecare nursing is scarce and further information is warranted about citizens’ perceptions of receiving home care under existing conditions. The purpose of this study was to investigate citizen experiences with health-care professionals in the time allotted for home care.

Design/methodology/approach
A questionnaire survey was distributed to 348 citizens receiving home care. The questionnaire consisted of questions whether the citizens experienced that enough time was available during the homecare visit and how the conversation and care relationship with the health-care professionals were experienced. The differences in responses were analysed using Fisher’s Exact Tests.

Findings
Overall, 94% of the citizens reported that sufficient time had been available and that care relationship and conversation with the health-care professionals had been positive during the homecare visit. However, the findings indicated that citizens aged more than +76 years and citizens with a high educational level were more prone to report that the nurses did not spend enough time during the home visit.

Originality/value
The findings offer useful insights for the professionals in delivering appropriate home care. Listening to citizens’ wishes and needs for home care could lead to better individualised care. Especially the youngest and oldest of the citizens seem to have specific experiences that call for further investigation.
Effects of public infrastructural development and industrialization on economic complexity in Africa: Emerging insight from panel data analysis
Authors: Emeka Ekene ThankGod , Ogbuabor Jonathan E. , Nwosu Emmanuel O. 
Published: January 2024

AbstractThis study examined the effects of public infrastructural development and industrialization on economic complexity in Africa, and how industrialization is moderating the effect of public infrastructural development on economic complexity. The study adopted the pooled ordinary least squares, the dynamic system generalized method of moments and the dynamic bias‐corrected least squares dummy variable estimators with a panel of 34 African economies over the period 2010–2021. The findings revealed that public infrastructural development and industrialization contribute positively and significantly toward enhancing economic complexity in Africa. We also found that industrialization substantially moderates and enhances the influence of public infrastructural development on economic complexity. Furthermore, the results show that trade openness, foreign direct investment inflow, international tourism arrival and institutional quality are potent factors enhancing Africa's economic complexity, while the role of human capital remains muted. These findings suggest that African leaders and policy‐makers can foster economic complexity across the continent by embracing policies that prioritize increased infrastructural development, industrialization, trade openness and foreign direct investment inflow while improving the quality of institutions within the region.
A review of age estimation methods in non‐avian reptiles by growth marks in hard tissues
Authors: SZÉKELY Diana , STĂNESCU Florina , SZÉKELY Paul , TELEA Alexandra E. , COGĂLNICEANU Dan 
Published: January 2024

AbstractAge and growth‐related data are basic biological parameters, essential in population ecology, evolution, and conservation biology. There is a growing body of published information on reptile demography derived from sclerochronology, a technique based on counting the growth layers deposited in bones (skeletochronology) and other hard body structures. Since the data are not always easily available, we compiled the existing published data, described the current status of knowledge, synthetized the conclusions of disparate studies, and identified patterns of research and information gaps, prioritizing the needs for future research. Our database includes the results of 468 published studies covering 236 reptile species from 41 families. These represent less than 2% of the total number of known extant species. Turtles and crocodiles are proportionally better studied, while snakes are the least examined group. The distribution of the research does not reflect conservation needs; we found an important geographic bias, with an overrepresentation of Northern temperate species. Only 23% of the studies checked the assumption of periodicity of growth marks deposition, and the method was found to be reliable or adequate in 79% of the cases. Overall, the data obtained through sclerochronology can be considered robust, especially if validation methods are employed, since the general goal is to characterize population parameters, trends, and dynamics, rather than determining the exact age of any specimen in particular.
Sugar reduction in chocolate compound by replacement with flours containing small insoluble starch granules
Authors: Ma Kai Kai , Ziegler Gregory R. , Hayes John E. 
Published: January 2024

AbstractConsumer concern about intake of added sugars has increased commercial demand for sugar‐reduced chocolates. However, substitution with high‐potency sweeteners is not possible as sugar serves as an important bulking agent. Here, we investigated replacement of sucrose in chocolate compound with oat or rice flours, with starch granules smaller than 10 µm, focusing on texture, sweetness, and acceptability. In Study 1, six chocolates were made: a control with 54% sucrose, four sucrose‐reduced versions (reductions of 25% or 50%, using either oat or sweet rice flour), and one 54% sucrose chocolate with reduced refining time. These chocolates were compared in a Difference from Control (DFC) test in a within‐subject design, with and without nose clips. Particle size distribution, yield stress, and plastic viscosity were measured. Chocolates with 25% sucrose reduction by either sweet rice or oat flour (or reduced refining time) were not significantly different from the blind control (p > 0.05), regardless of nose clip use. In open‐ended comments, participants reported differences in rice‐flour‐containing chocolates were due to a chalkier texture, while oat‐flour‐containing chocolates were described as smoother, softer, and creamier. DFC scores from the chocolates were positively correlated with plastic viscosity and negatively correlated with yield stress. In Study 2, 25% reduced sugar chocolates made with rice flour were liked significantly less than control, but the oat flour sample did not differ from control. Collectively, these results suggest up to 25% of sucrose in chocolate can be replaced with oat flour without negatively affecting texture or consumer acceptance.
Probabilistic risk assessment for determining nonessential metals in commercial infant formula products in Taiwan
Authors: Liao Kai‐Wei , Lee Wei‐Ju , Lin Shao‐Chi , Tsao Yi‐Ning , Lin Hsin‐Ying , Liu Chen , Chin Wei‐Shan 
Published: January 2024

AbstractDuring the early months of life, infant formula plays a crucial role as a primary source of both food and essential nutrients for infants, serving as a replacement for or supplement to breast milk. However, nonessential metals in infant formulas are a concern because infants are highly vulnerable to chemical exposure. The aim of this study was to investigate infant exposure to nonessential metals in infant formula products in Taiwan and assess the associated health risks. In this study, concentrations of arsenic (As), barium (Ba), cadmium (Cd), manganese (Mn), lead (Pb), and vanadium (V) in 45 formula products for 0–1‐year‐old infants were determined by inductively coupled plasma mass spectrometry. The mean As, Ba, Cd, Mn, Pb, and V concentrations were 6.42, 280, 3.72, 1425, 20.4, and 21.9 µg/kg, respectively. According to our probabilistic simulation of the estimated daily intake of metals, the proportion of hazard quotients exceeding one was 7.69% for As and 3.29% for Mn, and that of hazard index (HI) values exceeding 1 was >17% for metals. Arsenic had the largest HI contribution (46.9%), followed by Mn (22.3%) and Pb (12.7%). The nonessential metals content in infant formula raises potential noncarcinogenic health concerns for infants in Taiwan. Therefore, regulations for nonessential metals must be imposed on related food products in Taiwan, with a particular focus on As and Mn.
Novel peptides from sea cucumber intestines hydrolyzed by neutral protease alleviate exercise‐induced fatigue via upregulating the glutaminemediated Ca2+/Calcineurin signaling pathway in mice
Authors: Lu Xutong , Wang Meng , Yue Hao , Feng Xiaoxuan , Tian Yingying , Xue Changhu , Zhang Tiantian , Wang Yuming 
Published: January 2024

AbstractSea cucumber intestines are considered a valuable resource in the sea cucumber processing industry due to their balanced amino acid composition. Studies have reported that peptides rich in glutamate and branched‐chain amino acids have anti‐fatigue properties. However, the function of the sea cucumber intestine in reducing exercise‐induced fatigue remains unclear. In this study, we enzymatically hydrolyzed low molecular weight peptides from sea cucumber intestines (SCIP) and administered SCIP orally to mice to examine its effects on exercise‐induced fatigue using swimming and pole‐climbing exhaustion experiments. The results revealed that supplementation with SCIP significantly prolonged the exhaustion time of swimming in mice, decreased blood lactate and urea nitrogen levels, and increased liver and muscle glycogen levels following a weight‐loaded swimming test. Immunofluorescence analysis indicated a notable increase the proportion of slow‐twitch muscle fiber and a significant decrease the proportion of fast‐twitch muscle fiber following SCIP supplementation. Furthermore, SCIP upregulated mRNA expression levels of Ca2+/Calcineurin upstream and downstream regulators, thereby contributing to the promotion of skeletal muscle fiber type conversion. This study presents the initial evidence establishing SCIP as a potential enhancer of skeletal muscle fatigue resistance, consequently providing a theoretical foundation for the valuable utilization of sea cucumber intestines.
Isochoric freezing to extend the shelf life of pomegranate juice
Authors: Lou Leo , Takeoka Gary , Rubinsky Boris , Bilbao‐Sainz Cristina 
Published: January 2024

AbstractPomegranate juice was treated by isochoric freezing (−15°C/130 MPa) for 24 h and then stored under three different conditions for up to 4 weeks: 4°C/0.1 MPa, 24°C/0.1 MPa, and −10°C/100 MPa. The juice microbiological stability and quality were compared to those using heat treatment at 95°C for 15 s followed by cold storage at 4°C. Heat‐treated and isochoric frozen (IF) pomegranate juice stored under isochoric conditions showed no spoilage microorganisms after 4 weeks of storage. Also, IF juice stored at 4 or 24°C for 4 weeks had lower microbial loads than those in fresh pomegranate juice. IF juice stored under isochoric conditions showed greater color stability, antioxidant capacity, and nutrient retention (anthocyanins, ascorbic acid, and total phenolic compounds) than heat‐treated juices stored at 4°C. IF juice stored at 4°C also showed greater anthocyanin and ascorbic acid contents compared with heat‐treated juice.Practical ApplicationIsochoric freezing storage at −10°C can be used to preserve the quality properties of fresh pomegranate juice. Isochoric freezing at −15°C for 24 h can also be used as a pretreatment to extend the shelf life of refrigerated pomegranate juice since the applied pressures reached total inactivation levels of spoilage microorganisms.
Can digital self‐harm relate to suicidal thoughts and behaviors beyond physical self‐harm?
Authors: Wang Juan , Wei Ziqian , Jia Luxia , Yu Jiaao , Wang Yuanyuan , Meng Yaxuan , Feng Yi , Chen Runsen 
Published: January 2024

AbstractBackgroundDigital self‐harm (DiSH) is a recently identified self‐harm distinct from physical self‐harm (PSH, also known as non‐suicidal self‐injury, NSSI). Although prior research has shown that DiSH was associated with suicidal thoughts and behaviors (STBs), it was still unclear whether DiSH has a unique association with STBs after controlling for PSH.MethodA cross‐sectional survey was conducted on Chinese college students. The lifetime prevalence of DiSH and PSH, the functions of DiSH, recent suicide experiences (including suicide ideation, plans, and attempts), anxiety and depression were examined. A total of 5281 participants were analyzed.ResultsA total of 10.83% of participants had ever engaged in DiSH, and 1.59% of participants reported histories of both DiSH and PSH. Among participants with a history of PSH, 30.11% engaged in DiSH. Engagement in DiSH was significantly associated with suicide ideation (SI), suicide plans (SPs), and suicide attempts (SAs). More importantly, participants who engaged in both DiSH and PSH showed higher odds of SI and SPs compared to those who had only engaged in PSH. Regarding the functions of DiSH, using DiSH for self‐punishment was associated with SI and SPs, and using DiSH for sensation seeking was associated with SPs and SAs. Similar results were found for the association between DiSH and anxiety and depression.ConclusionsOur findings suggest that DiSH has a unique association with the risks of STBs beyond PSH. Early identification and intervention for DiSH are crucial, even for individuals who already engage in PSH.
Does membership in seed producer cooperatives improve smallholders’ teff productivity? A comparative analysis in North Ethiopia
Authors: Gebrehiwot Nahusenay Teamer , Gezahegn Tafesse W. , Abbay Aradom Gebrekidan , Entehabu Tesfay Gebrehiwet , Beyene Alemtsehay Tsegay , Tesfay Asfafaw Haileslassie , Sebhatu Kifle Tesfamariam 
Published: January 2024

AbstractAlthough teff (Eragrostis tef) is a very important staple food crop in Ethiopia, its production is constrained by low productivity due to poor access and adoption rate of improved seed by farmers. The government of Ethiopia envisions realizing an efficient teff value chain that enables a sustainable increase of smallholder teff productivity. As a result, the government is supporting seed producer cooperatives (SPCs) to supply improved teff seeds to farmers. The aim of this study is to compare teff productivity at household level among members and nonmembers of SPCs. To this end, a cross‐sectional survey design with multi‐stage sampling method was used to select 386 sample households (193 SPC members and 193 nonmembers). As membership in a cooperative is voluntary, farmers may self‐select into a given SPC according to their own motivation and interest. In a bid to address the potential issue of selection bias from both observed and unobserved heterogeneities, we employ the treatment effects model (TEM), which allows for a specific correlation structure between the unobservables that affect the treatment and the unobservables that affect the potential outcomes. Results show that, on average, SPC members produce 1.406 more quintals per hectare compared with their nonmember counterparts.
Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes
Authors: Ebea‐Ugwuanyi Pearl O. , Vidyasagar Sadasivan , Connor James R. , Frazer David M. , Knutson Mitchell D. , Collins James F. 
Published: January 2024

SummaryIron deficiency (ID) and iron‐deficiency anaemia (IDA) are global public health concerns, most commonly afflicting children, pregnant women and women of childbearing age. Pathological outcomes of ID include delayed cognitive development in children, adverse pregnancy outcomes and decreased work capacity in adults. IDA is usually treated by oral iron supplementation, typically using iron salts (e.g. FeSO4); however, dosing at several‐fold above the RDA may be required due to less efficient absorption. Excess enteral iron causes adverse gastrointestinal side effects, thus reducing compliance, and negatively impacts the gut microbiome. Recent research has sought to identify new iron formulations with better absorption so that lower effective dosing can be utilized. This article outlines emerging research on oral iron supplementation and focuses on molecular mechanisms by which different supplemental forms of iron are transported across the intestinal epithelium and whether these transport pathways are subject to regulation by the iron‐regulatory hormone hepcidin.
Nivolumab receptor occupancy on effector regulatory T cells predicts clinical benefit
Authors: Hosonuma Masahiro , Hirasawa Yuya , Kuramasu Atsuo , Murayama Masakazu , Narikawa Yoichiro , Toyoda Hitoshi , Baba Yuta , Isobe Junya , Funayama Eiji , Tajima Kohei , Shida Midori , Hamada Kazuyuki , Tsurui Toshiaki , Ariizumi Hirotsugu , Ishiguro Tomoyuki , Suzuki Risako , Ohkuma Ryotaro , Kubota Yutaro , Horiike Atsushi , Sambe Takehiko , Tsuji Mayumi , Wada Satoshi , Kiuchi Yuji , Kobayashi Shinichi , Tsunoda Takuya , Yoshimura Kiyoshi 
Published: January 2024

AbstractImmune checkpoint inhibitor discovery represents a turning point in cancer treatment. However, the response rates of solid tumors remain ~10%–30%; consequently, prognostic and immune‐related adverse event (irAE) predictors are being explored. The programmed cell death protein 1 (PD‐1) receptor occupancy (RO) of PD‐1 inhibitors depends on the number of peripheral blood lymphocytes and their PD‐1 expression levels, suggesting that the RO may be related to efficacy and adverse events. As PD‐1 inhibition affects each T‐cell subset differently, the RO of each cell population must be characterized. However, relevant data have not been reported, and the prognostic relevance of this parameter is not known. In this study, we aimed to clarify the association between the nivolumab RO in each T‐cell population and patient prognosis and reveal the development of irAEs in nivolumab‐treated patients. Thirty‐two patients were included in the study, and the mean follow‐up period was 364 days. The nivolumab RO on effector regulatory T cells (eTregs) was significantly lower in the group that presented clinical benefits, and a significant negative association was observed between PD‐1 occupancy on eTregs and all‐cause mortality. The results suggest that the nivolumab RO on eTregs may be a prognostic factor in PD‐1 inhibitor therapy, implying that the inhibition of PD‐1/PD‐ligand 1 (PD‐L1) signaling on eTregs may attenuate antitumor effects.
Efficacy and safety of intragastric expandable oral capsules in adults with overweight or obesity: A randomized, double‐blind, placebo‐controlled trial
Authors: Lu Difei , Yuan Zhenfang , Guo Xiaohui , Zhu Liyong , Zhang Fan , Li Xuejun , Wang Wenbo , Lin Huandong , Luo Jingnan 
Published: January 2024

AbstractAimThis trial assessed the efficacy and safety of 2.24 g intragastric expandable capsules twice per day versus placebo for weight management in adults with overweight or obesity.MethodsThis double‐blind, placebo‐controlled study included adults with a body mass index of at least 24 kg/m2 and no more than 40 kg/m2. In total, 280 participants were recruited from six hospitals in China and were assigned in a 1:1 ratio to receive 2.24 g oral intragastric expandable capsules or placebo for 24 weeks. Coprimary endpoints were the percentage change in body weight from baseline and the rate of weight reduction of ≥5%, assessed using both the full analysis set and per protocol set.ResultsAt baseline, the mean body weight was 81.8 kg, and the mean body mass index was 29.4 kg/m2. The mean body weight change at week 24 was −4.9% with intragastric expandable capsules versus −1.9% with placebo [estimated treatment difference (ETD) −3.0%, 95% confidence interval (CI) −4.1 to −1.9; p < .001] using the full analysis set and −6.1% versus −2.5% (ETD −3.6%, 95% CI −5.0 to −2.3; p < .001), respectively, using the per protocol set. The percentage of participants who had weight loss exceeding 5% was 45.0% in the intragastric expandable capsule group versus 19.7% in the placebo group (ETD 25.3%, 95% CI 14.7‐35.9; p < .001) in the full analysis set and 55.9% versus 26.2% (ETD 29.6%, 95% CI 17.1‐42.2; p < .001), respectively, in the per protocol set. Waist circumference significantly decreased at week 24 (intragastric expandable capsules vs. placebo: −5.6 ± 8.3 cm vs. −2.9 ± 4.8 cm; p = .003). The most common adverse events associated with the use of intragastric expandable capsules were gastrointestinal disorders (intragastric expandable capsule vs. placebo, 25.0% vs. 21.9%), and most were mild and transient.ConclusionsIn this 24‐week trial including participants with overweight or obesity, 2.24 g of intragastric expandable capsules twice daily led to a clinically meaningful reduction in body weight compared with placebo.