bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial translocation of TFEB regulates complex I and inflammation
Authors: Calabrese Chiara , Nolte Hendrik , Pitman Melissa R , Ganesan Raja , Lampe Philipp , Laboy Raymond , Ripa Roberto , Fischer Julia , Polara Ruhi , Panda Sameer Kumar , Chipurupalli Sandhya , Gutierrez Saray , Thomas Daniel , Pitson Stuart M , Antebi Adam , Robinson Nirmal 
Published: January 2024

AbstractTFEB is a master regulator of autophagy, lysosome biogenesis, mitochondrial metabolism, and immunity that works primarily through transcription controlled by cytosol-to-nuclear translocation. Emerging data indicate additional regulatory interactions at the surface of organelles such as lysosomes. Here we show that TFEB has a non-transcriptional role in mitochondria, regulating the electron transport chain complex I to down-modulate inflammation. Proteomics analysis reveals extensive TFEB co-immunoprecipitation with several mitochondrial proteins, whose interactions are disrupted upon infection withS. Typhimurium. High resolution confocal microscopy and biochemistry confirms TFEB localization in the mitochondrial matrix. TFEB translocation depends on a conserved N-terminal TOMM20-binding motif and is enhanced by mTOR inhibition. Within the mitochondria, TFEB and protease LONP1 antagonistically co-regulate complex I, reactive oxygen species and the inflammatory response. Consequently, during infection, lack of TFEB specifically in the mitochondria exacerbates the expression of pro-inflammatory cytokines, contributing to innate immune pathogenesis.
A high‐integration dual‐resonance element with independent frequency tuning for wideband reflectarrays
Authors: Liu Meicheng , Hou Yuefeng 
Published: January 2024

AbstractIn this letter, a novel design methodology of dual‐resonance elements for wideband reflectarrays is proposed for the first time. The alluring merits of this design lie in the compact common‐via dual‐resonance element with weak inner coupling and independent frequency tuning. To improve compactness, a traditional dipole is terminated by a metallic via connected to the ground plane. The element operates in monopole mode, decreasing the size by half. To realize a high‐integration dual‐resonance element, two monopoles operating at different frequencies are adopted to construct an asymmetric common‐via element, with an equivalent size to the traditional dipole resonating at merely one frequency. The first‐ever proposed element embodies superiorities of compactness, independent frequency tuning, and low profile. The proof‐of‐concept is validated by a fabricated reflectarray. The elaborately designed element with a compact size of 0.42 λ × 0.105 λ × 0.0737 λ exhibits an extended phase range of 484° at 14 GHz. The measured 3‐dB gain bandwidth is 36% (12.5–18 GHz) with a maximum gain of 26.9 dBi. The design strategy is capable of integrating more resonant structures in a compact area, rendering it suitable for broadband reflectarrays.
Subjective Smell Disturbances in Children with Sars-Cov-2 or Other
Viral Infections do not Correspond with Olfactory Test Results
Authors: Grote Hanna , Hoffmann Anna , Kerzel Sebastian , Lukasik Hannah , Maier Christoph , Mallon Claire , Schlegtendal Anne , Schwarzbach Michaela , van Ackeren Konstantin , Volkenstein Stefan , Brinkmann Folke 
Published: January 2024

Abstract
Background Olfactory dysfunction associated with SARS-CoV-2 infection in
children has not been verified by a validated olfactory test. We aimed to
determine whether these complaints are objectifiable (test-based hyposmia), how
often they occur during acute SARS-CoV-2 infection compared to other upper
respiratory tract infections (URTI), as well as in children recovered from
COVID-19 compared to children with long COVID.
Methods Olfactory testing (U-sniff test; hyposmia<8 points) and
survey-based symptom assessments were performed in 434 children (5–17
years; 04/2021–06/2022). 186 symptom-free children
served as controls. Of the children with symptoms of acute respiratory tract
infection, SARS-CoV-2 PCR test results were positive in 45 and negative in 107
children (URTI group). Additionally, 96 children were recruited at least 4 weeks
(17.6±15.2 weeks) after COVID-19, of whom 66 had recovered and 30 had
developed long COVID.
Results Compared to controls (2.7%), hyposmia frequency was
increased in all other groups (11–17%, p<0.05), but no
between-group differences were observed. Only 3/41 children with
hyposmia reported complaints, whereas 13/16 children with complaints
were normosmic, with the largest proportion being in the long-COVID group
(23%, p<0.05).
Conclusion Questionnaires are unsuitable for assessing hyposmia frequency
in children. Olfactory complaints and hyposmia are not specific for SARS-CoV-2
infection. The number of complaints in the long-COVID group could result from
aversive olfactory perception, which is undetectable with the U-sniff test.
Akzeptanz digitaler Gesundheitsanwendungen bei Osteoporose – eine
Patientenbefragung
Authors: Kabus Sara , Mollenhauer Judith , Kurscheid Clarissa , Maus Uwe , Niedhart Christopher 
Published: January 2024

Zusammenfassung
Hintergrund Im Hinblick auf die Entwicklung des
Disease-Management-Programms (DMP) Osteoporose und die digitale Transformation
des Gesundheitswesens wurde untersucht, inwieweit Osteoporose-Patient:innen im
Alltag digitale Hilfsmittel nutzen und wie hoch die Bereitschaft zur Nutzung
einer digitalen Gesundheitsanwendung (DiGA) bei Osteoporose ist.
Methode Im Zeitraum von Juni 2021 bis Februar 2022 wurde eine
Paper-Pencil-Fragebogenbefragung mit an Osteoporose erkrankten
Selbsthilfegruppe-Mitgliedern über den Bundesselbsthilfeverband für Osteoporose
e.V. durchgeführt. Es wurden 13.700 Fragebögen über die Mitgliederzeitschrift
„Osteoporose“ versendet. Die Rücklaufquote betrug 9,1% (1.248 Fragebögen). 1.241
Fragebögen sind in die Auswertung eingeflossen.
Ergebnis 93,9% (n=1.156) der Befragten sind zwischen 60 und 89 Jahren alt,
die Gruppe der 70-79-Jährigen war mit 42,2% (n=519) die größte Altersgruppe.
64,8% (n=776) der Befragten gaben an, ein Smartphone zu besitzen. Davon nutzten
83,5% (n=628) es täglich vor allem zum Telefonieren sowie Surfen im Internet.
57,1% der Befragten können sich vorstellen, eine Osteoporose-App zu nutzen, die
vor allem über Osteoporose informieren (91%), Daten messen (74%) sowie
Motivationsbotschaften senden soll (68%).
Schlussfolgerung Es scheint eine generelle Bereitschaft zur Nutzung
digitaler Anwendungen bei der älteren Klientel zu bestehen, auch bezüglich eines
Gesundheitsmonitorings. Es ist davon auszugehen, dass die bereits vorhandene
Nutzungsbereitschaft weiter steigen wird, da Folgegenerationen Digital Natives
sein werden. Digitale Angebote könnten über Selbsthilfemöglichkeiten informieren
und Daten messen. Mehr als 1/3 der Antwortenden gab an, eine DiGA zur
Mitbehandlung der Osteoporose nutzen zu wollen. Mit Blick auf das DMP
Osteoporose können DiGAs als unterstützende Therapiebegleitung eingesetzt
werden.
Ultrasound-Navigated Multiple Hippocampal Transections: An Anatomical Study
Authors: Sroubek Jan , Kramska Lenka , Cesak Tomas , Amlerova Jana , Keller Jiri , Vojtech Zdenek 
Published: January 2024

Abstract
Background Multiple hippocampal transection (MHT) is a surgical technique used for the treatment of drug-resistant mesial temporal lobe epilepsy in situations where standard procedures would pose a high risk for memory deterioration. During MHT, the longitudinal fibers of the hippocampus, implicated in epilepsy spreading, are interrupted, while the transverse memory circuits are spared. The extent of MHT is governed by intraoperative electrocorticography; abolition of epileptic discharges serves as an end point to terminate the transection. In other words, the aim of MHT is not the anatomical completeness of hippocampal transection. In contrast, we hypothesize that only the complete transection of hippocampal cross-section is needed to durably terminate epilepsy, avoiding possible postoperative reorganization of longitudinal pathways. Here, we report an anatomical study designed to evaluate the feasibility of complete transection of hippocampus with the aid of ultrasound neuronavigation and we propose new instruments to reach this goal.
Methods Five cadaveric brains were analyzed in this study. MHT was performed on both sides of each brain either with or without ultrasound neuronavigation. The percentage of transected cross-section of the hippocampus was measured using magnetic resonance imaging (MRI) and both sides were compared.
Results The ultrasound-guided MHTs were more likely to achieve complete hippocampal transection compared with the nonnavigated MHT transection (73 vs 58%; p < 0.01). Our study also allowed us to propose specialized transectors to minimize invasivity of this procedure.
Conclusion Completeness of MHT can be better reached with the aid of an ultrasound neuronavigation system; modified instruments for this procedure were also designed.
Superficial Digital Flexor Tendon Contracture in a Dog with Gastrocnemius Tendon Avulsion
Authors: da Costa Laura Marques , Marshall William G. 
Published: January 2024

AbstractAvulsion of the gastrocnemius component of the Achilles tendon is a well-documented condition in dogs. The most common treatment is to restore tendon function with surgical reattachment to the tuber calcanei. However, repair can fail. Pantarsal arthrodesis cannot only salvage a failed repair but is also a first-line treatment that may have a more predictable outcome. We describe a case of contracture of the superficial digital flexor tendon (SDFT) in the hindlimb of a dog with avulsion of the gastrocnemius component of the Achilles tendon, treated previously by pantarsal arthrodesis. Digital flexion and lameness persisted despite non-surgical treatment, and tenotomy of the SDFT was performed at the level of distal calcaneus to allow digit extension. The dog was re-examined 2 weeks and more than 2 years after surgery. No complications occurred, and the dog maintained an excellent long-term improvement in limb function.
Artificial Intelligence-Based Prediction of Contrast Medium Doses for Computed Tomography Angiography Using Optimized Clinical Parameter Sets
Authors: Fleitmann Marja , Uzunova Hristina , Pallenberg René , Stroth Andreas M. , Gerlach Jan , Fürschke Alexander , Barkhausen Jörg , Bischof Arpad , Handels Heinz 
Published: January 2024

Abstract
Objectives In this paper, an artificial intelligence-based algorithm for predicting the optimal contrast medium dose for computed tomography (CT) angiography of the aorta is presented and evaluated in a clinical study. The prediction of the contrast dose reduction is modelled as a classification problem using the image contrast as the main feature.
Methods This classification is performed by random decision forests (RDF) and k-nearest-neighbor methods (KNN). For the selection of optimal parameter subsets all possible combinations of the 22 clinical parameters (age, blood pressure, etc.) are considered using the classification accuracy and precision of the KNN classifier and RDF as quality criteria. Subsequently, the results of the evaluation were optimized by means of feature transformation using regression neural networks (RNN). These were used for a direct classification based on regressed Hounsfield units as well as preprocessing for a subsequent KNN classification.
Results For feature selection, an RDF model achieved the highest accuracy of 84.42% and a KNN model achieved the best precision of 86.21%. The most important parameters include age, height, and hemoglobin. The feature transformation using an RNN considerably exceeded these values with an accuracy of 90.00% and a precision of 97.62% using all 22 parameters as input. However, also the feasibility of the parameter sets in routine clinical practice has to be considered, because some of the 22 parameters are not measured in routine clinical practice and additional measurement time of 15 to 20 minutes per patient is needed. Using the standard feature set available in clinical routine the best accuracy of 86.67% and precision of 93.18% was achieved by the RNN.
Conclusion We developed a reliable hybrid system that helps radiologists determine the optimal contrast dose for CT angiography based on patient-specific parameters.
Technical NEMA NU2–2018 Performance Assessment of Time-of-Flight-Integrated Digital PET-CT System
Authors: Singh Manoj Kumar , Agarwal Krishan Kant , Vishwakarma Manish , Patel Hemant 
Published: January 2024

Abstract
Aim The objective of this study includes the NEMA (National Electrical Manufacturer Association) NU2–2018 performance evaluation of the uMIvista PET-CT (positron emission tomography-computed tomography) system.
Methods The latest NEMA NU2–2018 guidelines have been followed for the evaluation of performance parameters of this PET-CT scanner: axial, tangential, and radial spatial resolution, sensitivity, counting losses, scatter, randomness, random and counting loss correction, image quality, time and energy resolution, image uniformity, and image registration alignment post installation of country first uMIvista PET-CT.
Results The measured NEMA sensitivity of the uMIvista PET scanner was 12.053 cps/kBq. The spatial resolutions of the PET were measured as tangential, radial, and transaxial spatial resolutions at 10 mm, with 3.01 mm, 2.95 mm, and 2.93 mm, respectively; at 100 mm, with 3.17 mm, 3.42 mm, and 3.05 mm, respectively; and at 200 mm, with 3.65 mm, 4.54 mm, and 3.17 mm, respectively, at full-width half-maximum (FWHM); while at full-width tenths-maximum (FWTM), the values at 10 mm were 5.79 mm, 5.57 mm, and 5.69 mm, respectively, and at 100 mm were 5.59 mm, 5.96 mm, and 5.91 mm, respectively. The measured time-of-flight (TOF) timing resolution was 302.294 ps and the measured energy resolution was 11.76% with FWHM and FWTM.
Conclusion The NEMA NU2–2018 performances of this TOF-integrated digital PET-CT system are extremely good in all parameters.
Effectiveness of Warm Water Foot Submerged Technique on the Level of Fatigue, Quality of Sleep, and Quality of Life among Patients with Cancer in Selected Hospital at Mangaluru
Authors: Vijayalaxmi Vijayalaxmi , Ullas Anju 
Published: January 2024

Abstract
Introduction Cancer is the most leading cause of death globally. Fatigue and poor quality of sleep are the common side effects of cancer treatment that lead to poor quality of life. There is a need of complementary therapy, which can help to minimize the side effects of cancer treatment and boosting relaxation. Warm water foot submerged technique helps to relieve fatigue and improve the quality of sleep; hence, quality of life can be improved. This study was conducted to assess effectiveness of warm water foot submerged technique on the level of fatigue, quality of sleep, and quality of life among patients with cancer.
Materials and Methods A quasi-experimental pretest and post-test control group research design was adopted to conduct the study in oncology ward of selected hospital. Sixty-eight participants were recruited using a nonprobability purposive sampling technique and allocated to intervention and control groups. Data was collected using multidimensional fatigue inventory, Groningen sleep quality scale, EORTC QLQ-C30. The control group received normal routine care and the intervention group received warm water foot submerged technique that was given for 15 minutes two times per day for 5 consecutive days.
Results Warm water foot submerged technique showed a significant difference in level of fatigue (p < 0.05), quality of sleep (p < 0.001), and quality of life (p < 0.001) in the intervention group. There was no significant difference in control group.
Conclusion This study showed that the warm water foot submerged technique is effective in reducing the fatigue and improving the quality of sleep and quality of life among patients with cancer. Thus, this study was found to be effective.
Correlation of Stature with Incisoapical Length of Anterior Teeth Using Cone-Beam Computed Tomography (CBCT)
Authors: Shinde Aditi , Reddy Mamatha GS , Gawali Rohan 
Published: January 2024

Abstract
Background Estimating stature is essential for the purpose of identifying human remains after death. It is common for the extremities or the head to be amputated from the trunk when the body has been severely disfigured. Odontometry's association with stature determination in forensic odontology required an estimate to be established.
Objective The objective of this study was to investigate and correlate stature (height) of the individual with the incisoapical length of the tooth
Material and Method The study was conducted on 106 participants, in which 53 were female and 53 male cases aged between 21 and 45 years. The study parameters included incisoapical length of maxillary and mandibular central incisor, lateral incisor and canine of both sides measured using cone-beam computed tomography, and height of an individual recorded using stadiometer. Pearson's correlation coefficient was calculated to study the correlation.
Results It is observed that the cervicoapical measurement of teeth does not show statistically significant correlation with the stature of the individual with the exception for tooth 22 (r = − 31, p = 0.02), 41(r = − 0.28, p = 0.04), and 42 (r = − 0.30, p = 0.02) among females and tooth 31 (r = − 0.35, p = 0.009) among males.
Conclusion A very small number of research on an individual's stature in relation to incisoapical length has been identified in the literature. The majority of an individual's anterior teeth's height was not significantly correlated with height.
Multiple Primary Malignancies and Bilateral Vocal Cord Paralysis Confusing the Management of Each Other
Authors: Mandepanda Sahana S. , Aroor Rajeshwary , Shetty Vijeth , Saldanha Marina 
Published: January 2024

AbstractDouble primary malignancy though uncommon, we often encounter in our clinical practice. The lung malignancy is known to cause left vocal cord paralysis. Bilateral abductor paralysis secondary to adenocarcinoma of the lung with concurrent basal cell carcinoma of the face is not common. Proper counseling and timely management are needed in these cases of multiple primary malignancies. Early evaluation in all cases of hoarseness can help in early diagnosis and management.
Exploring French language and culture instruction at an Algerian university: insights from L1 students’ perspectives
Authors: Benabbes Souad , Abu Taleb Hala AbdulHaleem 
Published: January 2024

AbstractNowadays, it is imperative to comprehend the relationship between intercultural communication and international representations of cultures and nations. This study focuses on exploring the representations that Junior Algerian students hold concerning the French language as well as culture, in order to apprehend students’ attitudes towards the language in question, identify pre-existing stereotypes, and eventually promote a more competent understanding of the culture associated with the language. Through surveys’ responses by 130 juniors at the University of Oum El Bouaghi who have undergone a year of training in French Civilization, researchers attempt to comprehend the impact of the programs followed on the potential reconfiguration of these representations and to identify the relationship of these future educators with the French language. The researchers adopt a descriptive-analytic approach to evaluate the effects of this on students’ conceptions and associated images, concerning the French culture as a whole. The responses exhibited less positive associations with France compared to the French language itself, revealing a positive shift in stereotypical images of French culture among university students. Adopting an intercultural dimension to investigate this underscores the need to prepare learners culturally as well as linguistically in order to effectively interact with different cultures.
Permanent-magnet-based transverse thermoelectric generator with high fill factor driven by anomalous Nernst effect
Authors: Ando Fuyuki , Hirai Takamasa , Uchida Ken-ichi 
Published: January 2024

A transverse thermoelectric generator for magnetic-field-free and high-density power generation utilizing the anomalous Nernst effect is constructed and its performance is characterized. By alternately stacking two different permanent magnets with the large coercivity and anomalous Nernst coefficients of opposite sign, transverse thermoelectric voltage and power can be generated in the absence of external magnetic fields and enhanced owing to a thermopile structure without useless electrode layers. In the permanent-magnet-based stack, the magnetic attractive force enables easy construction of the thermopile structure with a high fill factor. In this study, we construct a bulk module consisting of 12 pairs of SmCo5- and Nd2Fe14B-type permanent magnets having positive and negative anomalous Nernst coefficients, respectively, whose fill factor reaches ∼80%, whereas that of conventional thermoelectric modules based on the Seebeck effect is typically 30%–60%. We demonstrate magnetic-field-free anomalous Nernst power generation up to 177 µW at a temperature difference of 75 K around room temperature, which corresponds to the largest anomalous Nernst power density of 65 µW/cm2. The presented module structure concept will provide a design guideline for high-performance transverse thermoelectric power generation.
The semantic access mechanism of L3 Spanish words
Authors: Wang Ting , Yang Jingyun 
Published: January 2024

Abstract
This study investigates the lexical semantic access mode among students (n = 70) who speak
Chinese as their first language (L1), English as a second language (L2), and are in the process of learning Spanish as their third
language (L3). We use a cross-linguistic repetition priming paradigm with lexical decision tasks to assess whether semantic access
to L3 Spanish words is achieved with the help of L1 Chinese or L2 English translation equivalents. The results show that the
lexical semantic access mode varies depending on L3 proficiency level: Participants with high Spanish proficiency level have
direct access to the concepts, while nonproficient Spanish learners have access to the Spanish words’ conceptual representation
with the help of translation equivalents from both L1 Chinese and L2 English, which suggests that the Revised Hierarchical Model
(Kroll and Stewart, 1994) in second language acquisition (SLA) can be extended to
the third language acquisition (TLA) process. Our results also corroborate the Parasitic Model (Ecke, 2015), as trilingual speakers are shown to be dependent on previously acquired languages at the
initial stage.
Compact gap solitons and compact edge states of exciton–polariton condensates with spin–orbit coupling in a one-dimensional flatband lattice
Authors: Cheng Szu-Cheng , Chen Ting-Wei 
Published: January 2024

Abstract
We propose that the compact gap solitons and compact edge states can be excited in a flatband of the incoherently-pumped exciton–polariton condensate under a one-dimensional periodic potential lattice. The combined effects of spin–orbit coupling and periodic potential depth on the flatband structures are investigated. Then how the compact gap solitons and edge states are localized and extended inside only a fraction of a single lattice site will be studied with varying pump strengths, pump spot-sizes as well as energy detuning.