bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Model of Inhibition of the Catalytic Fragment of Domain ExoN of Exoribonuclease of Virus SARS-CoV-2-betacoronavirus B by Drug FS-1 Containing Molecular Iodine and Lithium and Magnesium Halides.
Authors: Yuldasheva Gulnara , Korotetskiy Ilya Sergeevich , Tabynov Kaissar , Tabynov Kairat , Ilin Aleksandr Ivanovich 
Published: January 2024

Abstract
Background: The 2020 pandemic has clearly shown the relevance of creating antiviral drugs. One of the targets of the drug is the active center of the vital enzymes of the virus. Such drugs include the antibacterial. and antiviral drug FS-1.
Method: For the study, a coronavirus cell culture line was used. The VERO C1008 cell culture [Vero 76, clone E6, Vero E6] (ATCC® CRL1586™) was adapted for use in the COVID-19 model. Antiviral activity of TI investigates in vitro by therapeutic, prophylactic and virus inhibition scheme.
Structures modeling the mechanism anticoronavirus effect of drug FS-1 are calculated using the approach DFT/B3PW91/6-31G**. Total energies of the complexes in aqueous solution calculated using model COSMO.
Result: Drug FS-1 substance has virus inhibitory activity at a concentration of 3.36 mg/ml in Vero E6 cell culture against coronavirus infection COVID-19 (strain hCoV19/Kazakhstan/KazNAU-NSCEDI-481/2020) in a dose of 100 TCID50/0.2 ml.
For the genome of the virus taken from isolate of SARS-CoV-2/INMI1/human/2020/ITA, the frequency of occurrence of nucleotide triplets has been analyzed. The most common triplet is AAA (281).
Using the DFT/B3PW91/6-31G** approach, it is shown the active complexes of drug FS-1: [MgI3LiII2]+ and Li(Cl)I3, can segregate from the dextrin helix and can form a complex with donor-active atoms of the triplet AAA of viral RNA.
Complexes of active center of nanocomplex FS-1 with triplet AAA destroy the complex formed by a phosphate group of viral RNA and a catalytic fragment of domain ExoN of exoribonuclease, and form a new nucleoprotein complex where lithium chloride and [MgI3LiII2]+ bind both viral RNA and magnesium ions of the catalytic fragment of domain ExoN of exoribonuclease. The conditions of cleavage of RNA are violated.
Conclusion Results of experimental research and the proposed molecular model show that the nanocomplex of drug FS-1 have anticoronavirus effect.
Occurrence of malignancies other than breast and ovarian cancer in female carriers of a BRCA1/2 germline pathogenic variant
Authors: Stuursma Annechien , Vegt Bert Van der , Berger Lieke P.V. , Hoor Maaike B. C. Ten , Oosterwijk Jan C. , Mourits Marian J. E. , De Bock Geertruida H. 
Published: January 2024

Abstract

Background
Women with BRCA1/2 germline pathogenic variants (GPV) have an increased risk of breast and tubal/ovarian cancer at an early age. Previous studies suggested an additional increased risk for other types of malignancies at early age, but risk estimates vary widely. The aim of the current study was investigate if female BRCA1/2 GPV carriers have an increased risk of malignancies other than breast and ovarian cancer at an early age.
Methods
Since 1994, women with a BRCA1/2 GPV are prospectively included in a data/biobank at our university hospital. Data were linked to PALGA: Dutch Pathology Registry. The primary outcome was defined as the incidence of malignancies other than breast and tubal/ovarian cancer before the age of 60 years and coded according to the International Classification of Diseases for Oncology. Incidences were compared to crude rates/100.000 person-years for the Netherlands, stratified by age and calendar time. Standardized incidence ratios (SIRs) were calculated with 95% confidence intervals (95%CIs).
Results
From 1347 women, 37,068 person-years were available, in which 82 malignancies other than breast and ovarian cancer under age 60 were detected. An increased risk of cancer in general (excluding breast and tubal/ovarian cancer) (SIR:2.25, 95%CI:1.78–2.80, P < 0.001), head and neck (SIR:3.17, 95%CI:1.03–7.39, p < 0.05), gastro-intestinal (SIR:1.96, 95%CI:1.14–3.13, p < 0.05) and female genital cancer (SIR:2.48, 95%CI:1.61–3.65, p < 0.001) was found.
Conclusions
Female carriers of BRCA1/2 GPV under 60 years of age have an increased risk to develop cancer in general (excluding breast and tubal/ovarian cancer), especially head and neck, gastro-intestinal and female genital cancer. If confirmed in larger, prospective studies that include the role of bias and previous cancer treatment, awareness of these risks could tailor prevention strategies and/or surveillance.
Stability of Subsea Tunnels Using Finite Element Limit Analysis and Adaptive Neuro-Fuzzy Inference System
Authors: Shafiee Amir Hossein , Oulapour Masoud , Abdlkadhim Mustafa Abd Ali 
Published: January 2024

Abstract
Construction of subsea tunnels has grown significantly in recent decades around the world. Hence, ensuring the stability of these tunnels is very important. However, investigating the stability of subsea tunnels has not received enough attention. In the present study, the finite element limit analysis (FELA) was used to determine the internal pressure needed to maintain the stability of circular subsea tunnels embedded in a Tresca material by considering various values for the influential parameters. It was observed that the required internal pressure, in a dimensionless form, increased by increasing soil cover and water depth. The failure mechanism was also investigated. It was observed that the mechanism did not cover the tunnel’s roof for lower values of soil cover and soil’s undrained shear strength. An adaptive neuro-fuzzy inference system (ANFIS) was implemented to predict the required dimensionless internal pressure. It was seen that in this regard, the performance of ANFIS was far better than the multiple linear regression (MLR).
Rehabilitation improves quality of life even in sarcopenia patients with hip fractures
Authors: Sawamura Hideaki , Inoue Hirokazu , Hayashi Yukinori , Masubuchi Masaaki , Takeshita Katsushi 
Published: January 2024

Abstract

Sarcopenia is becoming more common as the world’s population ages, and it has been noted that this condition reduces quality of life. The purpose of this study was to evaluate how sarcopenia affects rehabilitation after a hip fracture. This was a retrospective, single hospital observational study. We investigated patients who were hospitalized for rehabilitation after a hip fracture. The evaluation subjects were walking speed, Barthel Index, Berg Balance Scale (BBS), numerical rating scale of bodily pain (NRS), and calf circumference on admission and at discharge.128 patients were eligible. Sarcopenia affects 66.4% of the population. On discharge, the Barthel Index, BBS,and NRS in the sarcopenia group were greater than on admission. In the non-sarcopenia group, the Barthel Index on discharge was higher than on admission. On admission, the non-sarcopenia group had a higher Barthel Index, BBS, NRS, and circumference than the sarcopenia group. Patients with sarcopenia after hip surgery had an improved Barthel Index as a measure of activities of daily living and BBS as a measure of balance for rehabilitation. On admission, these outcomes were significantly worse in the sarcopenia group than in the non-sarcopenia group; however, they were significantly improved by postoperative rehabilitation of the hip fracture.
'Candidatus Phytoplasma mali' SAP11-Like protein modulates expression of genes involved in metabolic pathways, photosynthesis, and defense in Nicotiana occidentalis leaves.
Authors: Mittelberger Cecilia , Moser Mirko , Hause Bettina , Janik Katrin 
Published: January 2024

Abstract
Background: 'Candidatus Phytoplasma mali', the causal agent of apple proliferation disease, exerts influence on its host plant through various effector proteins, including SAP11CaPm which interacts with different TCP transcription factors. This study examines the transcriptional response of the plant upon early expression of SAP11CaPm. For that purpose, leaves of Nicotiana occidentalis H.-M. Wheeler were Agrobacterium-infiltrated to induce transient expression of SAP11CaPm and changes in the transcriptome were recorded until 5 days post infection.
Results: The analysis revealed that presence of SAP11CaPm in leaves leads to downregulation of genes involved in defense response and related to photosynthetic processes, while expression of genes involved in metabolic pathways was enhanced.
Conclusions: The results indicate that early SAP11CaPm expression might be important for the colonization of the host plant since phytoplasmas lack many metabolic genes and are thus dependent on metabolites from their host plant.
Irrigation in the North China Plain regulates the diurnal cycle of precipitation and regional water cycle
Authors: song yuanyuan , Wei Jiangfeng , Cheng Haoqiu , Zan Beilei 
Published: January 2024

Abstract

Irrigation, a significant human activity, impacts regional water cycles and climate. The effect of irrigation on the diurnal cycle of precipitation (DCP) remains ambiguous. In this study, we investigate irrigation's effects on the DCP and assess its contribution to precipitation in North China, utilizing a regional model coupled with a water vapor tracing scheme. Our findings indicate that, during the afternoon, irrigation in the North China Plain (NCP) generates a cooling effect, thereby intensifying the thermal contrast between the mountains and adjacent plain and strengthening the mountain-plains solenoid. As a result, there is an increase in the amount and frequency of afternoon precipitation in the northwestern mountains, while the southeastern plains experience a decrease. The cooling and moistening effects of irrigation inhibit the development of the planetary boundary layer and make it a challenge for air to reach the lifting condensation level, which impedes cloud and precipitation formation, thus delaying the peak of afternoon precipitation. Although irrigation's direct contribution to total precipitation does not exceed 6%, it is responsible for approximately 30% of the total precipitation changes induced by irrigation. The precipitation recycling ratio in the NCP is elevated under irrigation, especially in the mountains, likely due to enhanced moisture and altered local circulations. When the soil moisture is dry, irrigation's positive impact on precipitation is more pronounced, whereas in wet soil conditions, this positive effect diminishes and may even result in reduced precipitation.
Delayed breast reconstruction with autologous free flap after radiation therapy: Vascular complications and aesthetic outcomes
Authors: Miyazawa Kimie , Satake Toshihiko , Muto Mayu , Tsunoda Yui , Koike Tomoyuki , Narui Kazutaka , Katsuragi Ryouhei , Onoda Satoshi , Ishikawa Takashi 
Published: January 2024

Abstract

Background
The safety and outcome of breast reconstruction after radiotherapy are controversial, and the aesthetic aspects have not been studied extensively. We compared the results of vascular anastomosis, the incidence of postoperative complications, and aesthetic appearance between patients who had and had not received radiotherapy who then had undergone delayed breast reconstruction with autologous free flaps from abdomen, thighs, and buttocks.
Methods
We investigated 196 flaps implanted in patients who did not receive radiotherapy and 78 flaps implanted in patients who received radiotherapy before breast reconstruction in 256 patients. Of the 274 flaps, 230 came from the abdomen, 27 from the thighs, 14 from the buttocks, and 3 from other anatomic locations. We evaluated aesthetic outcomes in 107 patients who had not received radiotherapy and 45 who had.
Results
We found no significant differences between the two groups in incidence of vascular reanastomosis, time required for anastomosis, or incidence of unplanned reoperation. Complications such as flap necrosis were rare in both groups. Aesthetic outcomes were significantly better in the patients who had not received radiotherapy. Among the patients who had received radiotherapy, the aesthetic results were superior after two-stage reconstruction than after one-stage reconstruction.
Conclusions
Breast reconstruction with autologous free flaps can be performed safely in patients who have received radiotherapy, but the aesthetic result is slightly inferior to that in patients who had not received radiotherapy. In patients who have received radiotherapy, two-stage reconstruction tends to produce more aesthetically pleasing results than does one-stage reconstruction, but one-stage reconstruction is recommended if the breast skin exhibits radiation-induced changes.
Mechanical Behavior of Hot Extruded Aluminum 6082 Chip
Authors: Mahmoud Seif El Din , El-Gamasy Ramadan , El-Wahab Ayman Abd 
Published: January 2024

Abstract
In a bid to address the energy-intensive nature of primaryaluminum production, this study explores the solid-state recyclingof aluminum alloy 6082 chips through direct hot extrusion. Thechips were compacted at room temperature and extruded attemperatures of 350, 425, and 500°C, with reduction ratios of 6, 8.5,and 11. The influence of these extrusion parameters on themechanical behavior of the recycled material was thoroughlyinvestigated to optimize the recycling process. A comprehensiveanalysis of tensile properties, density variations, andmicrostructural changes was conducted. Experimental resultsrevealed a significant impact of varying extrusion parameters onmaterial properties. ANOVA and linear multiple regression analyseswere employed to establish relationships between extrusionconditions and mechanical properties. The findings underscore thepotential for enhanced recycling practices and sustainablemanufacturing.
The impact of Over The Top service providers on the Global Mobile Telecom Industry: A quantified analysis and recommendations for recovery
Authors: Awwad Ahmed 
Published: January 2024

Abstract
Telecom industry is significantly evolving all over the globe than ever. Mobile users’ number is increasing remarkably. Telecom operators are investing to get more users connected and to improve user experience, however, they are facing various challenges. Decrease of main revenue streams of voice calls, SMS (Short Message Service) and LDC (Long distance calls) with a significant increase in data traffic. In contrary, with free cost, OTT (Over the top) providers such as WhatsApp and Facebook communication services rendered over networks that built and owned by MNOs. Recently, OTT services gradually substituting the traditional MNOs' services and became ubiquitous with the help of the underlying data services provided by MNOs. The OTTs' services massive penetration into telecom industry is driving the MNOs to reconsider their strategies and revenue sources.
Unique presentation of pycnodysostosis with multisuture craniosynostosis in a Sri Lankan child: a case report
Authors: Kolambage Yasas D. , Cooray Amila L. , Subasinghe Vindya , Liyanage Udari A. , Dissanayake Vajira H.W. 
Published: January 2024

Abstract

Background:
Pycnodysostosis is a rare skeletal dysplasia with autosomal recessive inheritance caused by loss-of-function variants in the CTSK gene. The report represents the first documented case of pycnodysostosis in Sri Lanka, distinguished by its novel and atypical presentation. This expands the known phenotypic spectrum of pycnodysostosis, emphasizing the impact of specific CTSK gene variants on clinical manifestations.
Case Presentation:
A 2-year-old Sri Lankan boy presented with failure to thrive and multisuture craniosynostosis. This atypical presentation was complicated by increased alkaline phosphatase levels and vitamin D deficiency, without any evidence of fractures. Exome sequencing revealed compound heterozygous variants in the CTSK gene: a pathogenic variant c.568C>T, p.(Gln190*) and a variant of uncertain significance c263A>C, p.(Gln88Pro). Parental testing confirmed autosomal recessive inheritance. The patient underwent surgical correction for craniosynostosis, orbital encephalocele reduction, and received treatment for vitamin D deficiency.
Conclusions:
The clinical features seen in this patient expand the phenotypic spectrum of pycnodysostosis and deepen the comprehension of the molecular mechanisms driving this uncommon genetic condition. It illustrates the possible impact of specific CTSK gene variants on phenotypic manifestations, such as craniosynostosis. Furthermore, this report provides a comprehensive account of the biochemical parameters of bone metabolism observed in patients previously diagnosed with pycnodysostosis, shedding light on the variability in laboratory findings and emphasizing the need for further investigation into the underlying molecular mechanisms.
Experimental and numerical research on pseudo-ductility of carbon/glass hybrid composites with unidirectionally arrayed chopped strands
Authors: Hu Junfeng , Huang Yinyuan , Jin Kefan , Zhang Xutong , Lu Wenlong , Zhang Siqi , Zhao Jianping , Chen Dingding 
Published: January 2024

Abstract
The mutual exclusion of strength and toughness in carbon fiber reinforced polymer (CFRP) composites has long perplexed composite material designers, despite the benefits of high specific strength and modulus in CFRP. In this study, unidirectionally arrayed chopped strands (UACS) are introduced into thin ply carbon fiber prepregs, which are stacked with S-glass fiber prepregs to fabricate carbon/glass hybrid laminates (C/G). Tensile characteristics and the mechanism of pseudo-ductility are explored experimentally and numerically in C/G hybrid laminates with varying material component ratios. In C/G hybrid specimens with the slit length of 20 mm and the material component ratio of 6%, obvious pseudo-ductility is found, and the pseudo-ductility strain increases by 116% as the C/G ratio increases from 6–18%, while the plateau stress reduces by 35.1%. The delamination propagation is reasonably even and slow in specimens with length slits of 20 mm, therefore, there is no rapid load drop during the tensile process. When the slit length is shorter than 20 mm, the stress concentration at the slit tip rises dramatically, resulting in more unstable load drops in load-displacement curves. The stress-strain curves derived by simulation correlate well with the experiment data, indicating that the numerical model used in this study is accurate.
Level of Knowledge and Awareness of Newly Diagnosed Cancer Patients about Cancer Diagnosis
Authors: Ön Sercan , SEVGEN Zeynep Gülsüm GÜÇ , ELLIDOKUZ Hulya , ÖZTOP İlhan 
Published: January 2024

Abstract
Purpose: Cancer is a global health problem that threatens lives worldwide. Awareness of cancer diagnosis varies over time. It differs according to the attitudes of societies, and there are not enough studies on this subject in Turkey, a Eurasian country.
Methods: Between January 1, 2018 and March 31, 2018, 159 newly diagnosed cancer patients who were admitted to the DEÜTF Medical Oncology Outpatient Clinic were included in the study. In order to evaluate the level of knowledge and awareness of the patients about their diseases, a questionnaire consisting of 21 questions was administered to them.
Results: 151 patients (95%) stated that they were informed about their disease, while 8 patients (5%) stated that no information was given. 11 (7%) relatives preferred to conceal the cancer diagnosis from the patient. Although awareness of cancer diagnosis was high, 25% of patients classified the level of knowledge provided as insufficient. It was found to be associated with advanced age, low income level, diagnosis in non-surgical clinics, lack of sufficient time during explanation and lack of using understandable language.
Conclusion: This study proved that attitudes towards providing information to cancer patients are similar to those in Western countries and have improved over time. Awareness of the cancer diagnosis contributes to patients' participation in treatment and decision-making processes, as well as a reduction in patient distress. For all these reasons, patients should be adequately informed about the diagnosis of cancer.
Research on intelligent identification of third-party damage of oil and gas pipelines based on improved YOLOv5 algorithm
Authors: Dai Xiaojun , Xiao Jianghong , Huang Weiyi , Liu Jianjun , li bin 
Published: January 2024

Abstract
In pipeline integrity management, third-party damage is an important cause of oil and gas pipeline failure and leakage. Among them, the safety threat to long-distance buried pipelines caused by excavators and other engineering vehicles is more prominent. For this reason, this paper proposes an automatic identification method of YOLOv5 engineering vehicles for video monitoring in high consequence areas. Firstly, for the variability of sunlight conditions and construction environment under actual working conditions, Mosaic9 data enhancement is used to create a more complex background and improve the robustness of the model. Second, the coordinate attention mechanism is introduced in the prediction layer to enhance the feature extraction capability of the model, thus solving the problem of complex background information and inconspicuous features of detection. Finally, the EIOU loss function is used to replace the CIOU function to improve the accuracy of the predicted border regression, which solves the problem of calculating the difference value of width and height instead of the aspect ratio. A dataset consisting of construction site photos obtained from surveillance cameras in the high consequence area of a section of pipeline in Guangdong Province is used to recognize four types of common construction vehicles, namely, excavators, loaders, rollers and heavy trucks, and the model is trained and tested on the actual engineering dataset. The experimental results show that the overall average detection accuracy mean value of the improved YOLOv5 algorithm is 81.3%, which is 3.6% higher than the original algorithm. Compared with other algorithms, the average mean precision is improved by 3.6%, the accuracy is improved by 0.5%, and the recall is improved by 3.0%, which obviously solves the problem of leakage detection that occurs in the recognition, and provides an effective solution for practical engineering applications.
Survival and causes of death in infants admitted in NICU in Tehran (a retrospective cohort study 2016-2022)
Authors: Dalili Hosein , Shariat Mamak , Sahebi Leyla 
Published: January 2024

Abstract

Neonatal mortality remains a global public concern. The aims of the study were the evaluation of survival in all admitted infants in the NICU, as well as predictors of neonatal mortality from 2016 to 2022. A retrospective cohort study was conducted among 7255 neonates admitted to the NICU in Valiasr Hospital (in the capital of Iran). Mortality proportion in preterm neonates was 9.1%, and 6.6% in all neonates. In most morbidites, the reduction of mortality was significant from 2016 to 2022.The most notable of them were respiratory disorders, prematurity, and sepsis. In the adjusted Cox regression, gestational age, birth weight, one and fifth-minute APGAR scores, congenital defects(HR = 2.02), sepsis (HR = 1.63), and respiratory disorders (HR = 1.40) were as predictor variables of death. Although the probability of survival seems to be increasing over the past years in Iran, it is far away from the target for 2030. The most common causes of neonatal mortality were congenital defects, sepsis, and respiratory disorders.
Recurrence relation approach for expansion and connection coefficients in series of q-Laguerre polynomials
Authors: Tcheutia Daniel Duviol , Mboutngam Salifou , Foupouagnigni Mama 
Published: January 2024

Abstract
In this manuscript, we expand some functions of a q-discrete variable as linear combination of the q-Laguerre polynomials. The recurrence relations satisfied by the expansion coefficients are derived and in many cases, explicit solutions of these recurrence relations are computed. We show how our results can be used to solve some q-difference equations and to illustrate this, we solve the connection problem between classical q-orthogonal polynomials and the q-Laguerre polynomials.
Mathematics Subject Classification (2010). 33D45, 42C10, 65Q30.