bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal bots carry relevant titers of CWD prions in naturally infected white-tailed deer
Authors: Soto Paulina , Bravo-Risi Francisca , Kramm Carlos , Gamez Nazaret , Benavente Rebeca , Bonilla Denise L , Reed J Hunter , Lockwood Mitch , Spraker Terry R , Nichols Tracy , Morales Rodrigo 
Published: January 2024

AbstractChronic wasting disease (CWD) is a prion disease affecting farmed and free-ranging cervids. CWD is rapidly expanding across North America and its mechanisms of transmission are not completely understood. Considering that cervids are commonly afflicted by nasal bot flies, we tested the potential of these parasites to transmit CWD. Parasites collected from naturally infected white-tailed deer were evaluated for their prion content using the protein misfolding cyclic amplification (PMCA) technology and bioassays. Here, we describe PMCA seeding activity in nasal bot larvae collected from naturally infected, nonclinical deer. These parasites efficiently infect CWD-susceptible mice in ways suggestive of high infectivity titers. To further mimic environmental transmission, bot larvae homogenates were mixed with soils, and plants were grown on them. We show that both soils and plants exposed to CWD-infected bot homogenates displayed seeding activity by PMCA. This is the first report describing prion infectivity in a naturally occurring deer parasite. Our data also demonstrate that CWD prions contained in nasal bots interact with environmental components and may be relevant for disease transmission.
BRD4 isoforms have distinct roles in tumour progression and metastasis in rhabdomyosarcoma
Authors: Das Dipanwita , Leung Jia Yu , Balamurugan Shivaranjani , Tergaonkar Vinay , Loh Amos Hong Pheng , Chiang Cheng-Ming , Taneja Reshma 
Published: January 2024

AbstractBRD4, a bromodomain and extraterminal (BET) protein, is deregulated in multiple cancers and has emerged as a promising drug target. However, the function of the two main BRD4 isoforms (BRD4-L and BRD4-S) has not been analysed in parallel in most cancers. This complicates determining therapeutic efficacy of pan-BET inhibitors. In this study, using functional and transcriptomic analysis, we show that BRD-L and BRD4-S isoforms play distinct roles in fusion negative embryonal rhabdomyosarcoma. BRD4-L has an oncogenic role and inhibits myogenic differentiation, at least in part, by activating myostatin expression. Depletion of BRD4-L in vivo impairs tumour progression but does not impact metastasis. On the other hand, depletion of BRD4-S has no significant impact on tumour growth, but strikingly promotes metastasis in vivo. Interestingly, BRD4-S loss results in the enrichment of BRD4-L and RNA Polymerase II at integrin gene promoters resulting in their activation. In fusion positive alveolar rhabdomyosarcoma, BRD4-L is unrestricted in its oncogenic role, with no evident involvement of BRD4-S. Our work unveils isoform-specific functions of BRD4 in rhabdomyosarcoma.
Les virus influenza, une écologie complexe
Authors: Bessière Pierre 
Published: January 2024

La diversité génétique des virus influenza A est considérable : les oiseaux aquatiques sauvages, considérés comme le réservoir de ces virus, hébergent dans leur tube digestif de très nombreux sous-types. Au fil des années, ils ont franchi la barrière d’espèce à de multiples occasions, et circulent aujourd’hui de manière pérenne chez plusieurs espèces. Ce sont les oiseaux domestiques qui paient le plus lourd tribut, du fait de l’existence de virus dits hautement pathogènes. Si notre territoire a connu par le passé plusieurs épizooties dévastatrices pour la filière volaille, jamais les virus influenza aviaire hautement pathogènes n’ont autant circulé en Europe. Au travers des différents articles de ce numéro, nous allons faire un état de l’art des connaissances actuelles sur ces virus.
Vers le déploiement de la vaccination contre l’IAHP
Authors: Bessière Pierre 
Published: January 2024

Les virus influenza aviaires hautement pathogènes (VIAHP) de clade 2.3.4.4b se sont propagés dans le monde entier, faisant courir une menace perpétuelle pour les oiseaux sauvages et domestiques, mais également pour les mammifères. Les mesures de biosécurité ne sont désormais plus suffisantes pour prévenir l’introduction des virus dans les élevages et les flambées épizootiques à partir des élevages infectés. La vaccination contre ce virus, interdite jusqu’à il y a peu dans l’Union Européenne, est désormais obligatoire en France dans les élevages de canard. Deux vaccins DIVA ont montré leur efficacité vis-à-vis des virus de ce clade chez les canards : ils diminuent fortement l’excrétion virale et protègent contre la transmission. Ainsi, depuis l’automne 2023, la vaccination est obligatoire pour tous les canards de l’étage production et est basée sur du volontariat pour l’étage multiplication. Afin de s’assurer que les virus ne circulent pas à bas bruit chez les animaux vaccinés, des plans de surveillance virologique active et passive seront mis en place. Les mouvements d’animaux vaccinés au sein du territoire national et de l’Union Européenne seront soumis à une nouvelle réglementation.
Un microbiote en bonne santé : un prérequis à la bonne régulation d’une infection par un VIAHP
Authors: Bessière Pierre 
Published: January 2024

Dès les premiers instants de la naissance, le microbiote, ce vaste écosystème microbien, colonise toutes les muqueuses. Il est désormais bien établi qu’il joue un rôle majeur dans la régulation du système immunitaire : en stimulant en permanence à bas bruit ce dernier, il le maintient dans un état de réactivité optimale. En ce qui concerne les virus influenza, cela avait été démontré chez la souris, mais jamais chez le canard. Grâce à une étude de l’ENVT, c’est maintenant chose faite : les canards dont le microbiote est profondément déstabilisé peinent à réguler la réplication virale, du fait d’une réponse immunitaire antivirale innée diminuée. La préservation du microbiote, via une utilisation raisonnée des antibiotiques, une ration alimentaire équilibrée et une limitation du stress, fait donc partie des mesures de prévention vis-à-vis des infections virales.
The impact of a social and emotional learning programme to improve pupils’ educational inclusion in vocational education and training
Authors: Fernández-Martín Francisco D. , Aznar-Díaz Inmaculada , Cáceres-Reche María-del-Pilar , Trujillo-Torres Juan-Manuel 
Published: January 2024

AbstractThe purpose of this study was to assess the effectiveness of a programme aimed at improving social and emotional competencies among pupils registered in Basic Vocational Education and Training (VET) from disadvantaged contexts. The sample consisted of 110 first-year pupils (55 experimental group and 55 control group) from three Basic VET programmes delivered in an educational centre. Social and emotional learning was assessed using the Social and Emotional Learning Scale. After assigning each classroom group of each Basic VET programme to the experimental or control condition, the programme was implemented during a whole scholar year. This intervention was carried out by a team of previously trained teachers and educators and embedded in the school curriculum. The results show large effect sizes and statistically significant differences in favour of the experimental group in social and emotional competencies. These promising results suggest considering this SEL intervention as an example of an evidence-based programme.
Affect in science communication: a data-driven analysis of TED Talks on YouTube
Authors: Fischer Olivia , Jeitziner Loris T. , Wulff Dirk U. 
Published: January 2024

AbstractScience communication is evolving: Increasingly, it is directed at the public rather than academic peers. Understanding the circumstances under which the public engages with scientific content is therefore crucial to improving science communication. In this article, we investigate the role of affect on audience engagement with a modern form of science communication: TED Talks on the social media platform YouTube. We examined how two aspects of affect, valence and density are associated with public engagement with the talk in terms of popularity (reflecting views and likes) and polarity (reflecting dislikes and comments). We found that the valence of TED Talks was associated with both popularity and polarity: Positive valence was linked to higher talk popularity and lower talk polarity. Density, on the other hand, was only associated with popularity: Higher affective density was linked to higher popularity—even more so than valence—but not polarity. Moreover, the association between affect and engagement was moderated by talk topic, but not by whether the talk included scientific content. Our results establish affect as an important covariate of audience engagement with scientific content on social media, which science communicators may be able to leverage to steer engagement and increase reach.
COVID-19 containment policies, digitalization and sustainable development goals: evidence from Alibaba’s administrative data
Authors: Zhou Xiaolan , Sawada Yasuyuki , Shum Matthew , Tan Elaine S. 
Published: January 2024

AbstractThe impact of digital platforms on the implementation of the United Nations’ (UN) Sustainable Development Goals (SDGs), especially the business sustainability of micro, small and medium-sized enterprises (MSMEs), under different containment policies during and after the COVID-19 pandemic has not yet been studied in detail. Using detailed administrative data from Alibaba Group’s online on-demand food delivery platform, we found that the digital platform contributed to the food security, wellbeing, employment and business sustainability of MSMEs both during and after the pandemic. We uncovered merchants’ heterogeneous responses to the COVID-19 pandemic during and after the implementation of different containment policies in China. On the extensive margin, the period of complete lockdown left long-term scarring on online merchants by decreasing the number of entrants, especially in the cooked food industry. In contrast, on the intensive margin, chain stores, especially those with large chain networks or multiapp stores, exhibited stronger resilience than their counterparts during and after lockdown. Thus, specialization (at the outlet level) and wider coverage (at the network level) emerged as key factors that enable business sustainability under challenging economic circumstances.
How deep is your trust? A comparative user requirements’ analysis of automation in medical and mobility technologies
Authors: Hick Sophia , Biermann Hannah , Ziefle Martina 
Published: January 2024

AbstractIn a changing world full of innovative technologies, trust and trust requirements are increasingly important for designing user-centred systems and ensuring their long-term implementation. In this study, we explored and compared the requirements of future users to build trust in the two contexts of medical and mobility technology by considering Ambient Assisted Living technologies (AAL) and Shared Autonomous Vehicles (SAV). We conducted an online survey study with N = 143 participants. The results show significant differences in the evaluation of individual trust requirements in the two contexts about data sharing, data privacy and security as well as customization. Using a cluster analysis, we identified distinct user groups and trust personalities in both contexts (medicine and mobility). The clusters differ in terms of innovation openness and risk readiness, initial trust, and presence of chronic illness. Correlation analyses revealed significant relationships between people’s initial perceived trust in technology in the two contexts and their assessment of trust requirements, as well as their behavioural intentions to use SAV or AAL systems. Our findings indicate that trust requirements are context-specific and influenced by individual characteristics. This knowledge can be used to inform developers and distributors of technologies to design, build, and manage systems that meet the needs of future users.
What shapes the financial capabilities of young adults in the US and Asia-Pacific region? A systematic literature review
Authors: Muat Susnaningsih , Mahdzan Nurul Shahnaz , Sukor Mohd Edil Abd 
Published: January 2024

AbstractYoung adults today face greater financial difficulties than previous generations as they transition from financial dependence to financial independence and require sufficient financial capabilities to overcome financial setbacks. Few studies, however, have conducted a detailed analysis of the literature on young adults’ financial capabilities in the Asia-Pacific region, home to over 1.1 billion young adults, and the US. Thus, this study systematically reviewed the literature addressing the factors affecting young adults’ financial capabilities in the US and the Asia-Pacific region, in accordance with the RepOrting standards for Systematic Evidence Syntheses (ROSES) publication standard and employing multiple research designs. The articles for this study were selected from two authoritative databases, Scopus and Web of Science, and a supplementary database, Google Scholar. Twenty-four articles were included for quality appraisal and qualitative synthesis based on predetermined criteria, including articles with empirical evidence published in English, with the US and Asia-Pacific countries as context and published after 2006. This review was divided into six major themes: (1) financial knowledge/literacy and education, (2) financial behaviour, (3) financial attitude, (4) financial inclusion, (5) financial socialisation, and (6) demographic characteristics. Eleven sub-themes were developed from the six major themes. The findings of this review identify three approaches to enhance the financial capability of young adults: (1) early financial education with practical simulations, which can promote positive financial attitudes and healthy financial behaviour; (2) assisting parents with adequate financial education given their role as the primary financial socialisation agents for young adults; and (3) coupling financial education with access to formal financial institutions. Additionally, this study provides insight into the directions that should be taken by future research endeavours.
A modular table-top setup for ultrafast x-ray diffraction
Authors: Lu W. , Nicoul M. , Shymanovich U. , Tarasevitch A. , Horn-von Hoegen M. , von der Linde D. , Sokolowski-Tinten K. 
Published: January 2024

We present a table-top setup for femtosecond time-resolved x-ray diffraction based on a Cu Kα (8.05 keV) laser driven plasma x-ray source. Due to its modular design, it provides high accessibility to its individual components (e.g., x-ray optics and sample environment). The Kα-yield of the source is optimized using a pre-pulse scheme. A magnifying multilayer x-ray mirror with Montel–Helios geometry is used to collect the emitted radiation, resulting in a quasi-collimated flux of more than 105 Cu Kα photons/pulse impinging on the sample under investigation at a repetition rate of 10 Hz. A gas ionization chamber detector is placed right after the x-ray mirror and used for the normalization of the diffraction signals, enabling the measurement of relative signal changes of less than 1% even at the given low repetition rate. Time-resolved diffraction experiments on laser-excited epitaxial Bi films serve as an example to demonstrate the capabilities of the setup. The setup can also be used for Debye–Scherrer type measurements on poly-crystalline samples.
Diachronic changes in constructional networks
Authors: Hölzl Andreas 
Published: January 2024

Abstract
This study investigates diachronic changes in constructional networks illustrated with examples from the Manchuric
branch of Tungusic, an endangered language family spoken in Northeast Asia. Earlier studies have noted pronounced differences
between this branch and the rest of the family, such as a reduction in morphological complexity and partial restructuring of the
morphosyntactic system. Based on the framework of Diachronic Construction Grammar, this study investigates aspects of nominal
morphology, including flagging and indexing. These are especially promising for a better understanding of the evolution of
Manchuric and have not often been discussed in terms of Construction Grammar.
Teaching prosody in research studies
Authors: Levis John M. 
Published: January 2024

Abstract
This special issue looks at the decisions behind prosody teaching in recently published L2 pronunciation studies.
The teaching of prosody can include a variety of topics (e.g., lexical stress, intonation, prominence, rhythm, etc.) and
approaches to teaching, but the justifications for the decisions about what to emphasize often are not extensively explained in
published articles. It is the intention of this issue to provide descriptions of a variety of studies, some face-to-face and some
using technology, in the hope that future studies focused on prosody will provide more complete accounts of their own decisions.
Each of the articles in this issue address decisions to teach prosody, the teaching approach of the study, materials used, and an
evaluation of the decisions made.
Is minority language use a right or a privilege?
Authors: Nagy Csongor István 
Published: January 2024

AbstractThis paper demonstrates how European institutions bend to the idea of the mono-ethnic and monolingual nation-state. Instead of encouraging the use of minority languages and accepting them as a value, minority languages are treated as a tolerated but voluntarily assumed handicap. This is in stark contrast to the treatment of other types of protected identities, such as religion, gender and sexual orientation. Against this background, there is a desperate need for clear value-setting by the European institutions and for a clear message that language shaming is not a venial sin of the monolingual nation-state but a no-go zone even for populists. For this, however, language chauvinism should not be condoned but condemned.
Cognitive attributes of preclassical phonology
Authors: Moreno-Fernández Francisco 
Published: January 2024

Abstract
Cognitive phonology, as a development of cognitive linguistics, is one of the most interesting fields of research in
the twenty-first century. It is often opposed to so-called “classical phonology”, since the latter mainly builds on
structuralist foundations. This chapter considers the proposals made between 1889 and 1921 concerning the concept of
“phoneme”, which coincide in many basic assumptions with contemporary cognitive phonology. Among these proposals, those of Jan
Baudouin de Courtenay are especially relevant, together with those of Edward Sapir. Basic concepts of cognitivism, such as
mental representation, similarity, social use and frequency, can be found in them, both explicitly and implicitly.
Social patterns in s-palatalisation in Moroccan and Turkish ethnolectal Dutch
Authors: Hinskens Frans , Ooijevaar Etske 
Published: January 2024

Abstract
This is a study of variable s-palatalisation in Turkish and Moroccan ethnolectal Dutch, with special attention to
its social distribution. Following a discussion of the phenomenon of ethnolectal variation, this chapter introduces the Roots
of Ethnolects project as well as the present sub-study. It then explores palatalisation both in general and specifically in
the realisation of /s/, before presenting the details of this study on s-palatalisation in the Roots of Ethnolects data,
including methodology, the speakers studied, material and data, coding, measurement and analysis. Lastly, it discusses the
findings from the point of view of the research questions guiding the Roots of Ethnolects project as well as issues for
further research.
Nuclear pitch accents in the assertive speech prosody of Acapulco, Mexico
Authors: Martín-Butragueño Pedro 
Published: January 2024

Abstract
This chapter studies certain aspects of assertive intonation in Acapulco, Mexico, using sociolinguistic interviews
from the Corpus oral del español de México. It presents acoustic and phonetic analysis that focuses on the
nuclear syllable and considers the type of boundary tone, tonal movement, syllable duration and the position of the tonal
peak, while examining the effects of information structure, age, gender and educational level. The results show that
information structure and age are significant in the distribution of nuclear pitch accents. The conclusions suggest a
retraction pattern of the most prominent tonal configurations and the grouping of the prosody of Acapulco with central Mexican
Spanish, although some degree of prosodic residue from the coast can also be observed.
Little words, small moves
Authors: Tsiplakou Stavroula 
Published: January 2024

Abstract
This paper explores clitic placement in two different varieties of Greek, Standard Modern Greek and Cypriot Greek,
and it is argued that, under heavy influence from the standard variety, the Cypriot variety is undergoing change as regards a
core property of its syntax, namely the placement of pronominal object clitics, since alongside structures where object
clitics appear in second position in the clause, they also tend to appear in the immediately preverbal position, as in
Standard Greek, the roofing standard for the Cypriot koine. An overview of existing studies is provided, after which the
argument is made for competing grammars; the availability in the Cypriot koine of the Standard Greek as well as the Cypriot
clitic placement strategy is accounted for on the basis of successful second dialect acquisition.
Ab initio investigation of the lattice dynamics and thermophysical properties of BCC vanadium and niobium
Authors: Pandey Prakash , Pandey Sudhir K 
Published: January 2024

Abstract
In the present work, we have performed the phonon dispersion calculations of body-centered cubic vanadium (V) and niobium (Nb) with the supercell approach using different supercell size. Using DFT method, the calculated phonon spectra of V and Nb are found to be in a good agreement with the available experimental data. Our calculated results show a ‘dip’-like feature in the longitudinal acoustic phonon mode along the Γ-H high symmetric path for both transition metals in the case of supercell size

4
×
4
×
4

. However, in supercell size

2
×
2
×
2

and

3
×
3
×
3

, the ‘dip’-like feature is not clearly visible. In addition to this, thermodynamical properties are also computed, which compare well with the experimental data. Apart from this, the phonon lifetime due to electron–phonon interactions (

τ

eph

ph

) and phonon–phonon interactions (PPIs) (

τ

ph

ph

) are calculated. The effect of PPIs is studied by computing the average phonon lifetime for all acoustic branches. The value of

τ

eph

ph

of V (Nb) is found to be 23.16 (24.70)

×

10

−
15

s at 100 K, which gets decreased to 1.51 (1.85)

×

10

−
15

s at 1000 K. The

τ

ph

ph

of V (Nb) is found to be 8.59 (18.09)

×

10

−
12

and 0.83 (1.76)

×

10

−
12

s at 100 and 1000 K, respectively. Nextly, the lattice thermal conductivity is computed using linearized phonon Boltzmann equation. The present work suggests that studying the variation of phonon dispersion with supercell size is crucial for understanding the phonon properties of solids accurately.
Classical route to ergodicity and scarring in collective quantum systems
Authors: Sinha Sudip , Ray Sayak , Sinha Subhasis 
Published: January 2024

Abstract
Ergodicity, a fundamental concept in statistical mechanics, is not yet a fully understood phenomena for closed quantum systems, particularly its connection with the underlying chaos. In this review, we consider a few examples of collective quantum systems to unveil the intricate relationship of ergodicity as well as its deviation due to quantum scarring phenomena with their classical counterpart. A comprehensive overview of classical and quantum chaos is provided, along with the tools essential for their detection. Furthermore, we survey recent theoretical and experimental advancements in the domain of ergodicity and its violations. This review aims to illuminate the classical perspective of quantum scarring phenomena in interacting quantum systems.