bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Nenhuma Pessoa Idosa Merece Passar por Isso”
Authors: Félix Rosas de Vasconcelos Emília Carolina , Pinheiro Costa e Silva Susanne , De Lima Maciel Maria Joycielle , Rodrigues de Lima Amanda Alana , Pereira Aprigio Silva Kelaine , Costa e Silva Mirella Maria 
Published: January 2024

Introdução: A violência contra idosos é um fenômeno crescente, ocasionando prejuízos à saúde, com diferentes desfechos e consequências às vítimas. A chance de idosas sofrerem-na no âmbito familiar supera a dos homens, sendo o gênero um fator de risco considerável.
Objetivo: Analisar a compreensão da violência contra pessoas idosas segundo mulheres gerontes.
Metodologia: Pesquisa descritiva com abordagem qualitativa desenvolvida com 22 idosas de uma comunidade no estado da Paraíba, Brasil, escolhidas por conveniência. Utilizou-se para coleta de dados entrevistas semiestruturadas, processadas pelo software Iramuteq, com posterior Análise de Conteúdo.
Resultados: Foram evidenciadas cinco classes: ciclo de violência; rede de apoio ao idoso vítima de violência; Vivência de situações violentas; violência financeira; e simbologia da violência na sociedade, as quais denotam compreensão da violência envolvendo os diferentes tipos. Apoiam-se nos fatores da vivência familiar, cultura e outros, consubstanciando o profissional de saúde como fundamental para o desfecho. O gênero influenciou no que concerne ao olhar lançado sobre a violência física e psicológica, bem como na relevância dada às equipes de saúde para identificação de ocorrências e prevenção de possíveis danos.
Conclusão: Os diversos tipos de violência contra a pessoa idosa foram reconhecidos, incluindo fatores individuais, comunitários e sociais no ciclo violento. Além disso, associaram o envelhecimento a maior suscetibilidade para sofrer violência, independente da tipologia. Destaca-se a potencialidade do serviço de saúde na assistência à pessoa idosa vítima de violência, elucidando casos e atuando precocemente para interrupção dos ciclos perpetrados, exigindo a necessidade constante de atualização profissional para lidar com situações detectadas.
Using latent class analysis to identify different clinical profiles according to food addiction symptoms in obesity with and without binge eating disorder
Authors: Aloi Matteo , Liuzza Marco Tullio , Rania Marianna , Carbone Elvira Anna , de Filippis Renato , Gearhardt Ashley Nicole , Segura-Garcia Cristina 
Published: January 2024

AbstractBackground and aimsExisting research suggests that food addiction (FA) is associated with binge eating disorder (BED) and obesity, but the clinical significance of this relationship remains unclear. This study aims to investigate the different clinical profiles of FA symptoms among patients who have obesity with/without BED using latent class analysis (LCA).Methods307 patients (n = 152 obesity and BED, n = 155 obesity without BED) completed a battery of self-report measures investigating eating psychopathology, depression, emotional dysregulation, alexithymia, schema domains, and FA. LCA and ANOVAs were conducted to identify profiles according to FA symptoms and examine differences between classes.ResultsLCA identified five meaningful classes labeled as the “non-addicted” (40.4%), the “attempters” (20.2%), the “interpersonal problems” (7.2%), the “high-functioning addicted” (19.5%) and the “fully addicted” (12.7%) classes. Patients with BED and obesity appeared overrepresented in the “high-functioning addicted” and “fully addicted” classes; conversely, patients with obesity without BED were most frequently included in the “non-addicted” class. The most significant differences between the “high-functioning addicted” and “fully addicted” classes versus the “non-addicted” class regarded heightened severity of eating and general psychopathology.Discussion and conclusionsThe results bring to light distinct clinical profiles based on FA symptoms. Notably, the "high-functioning addicted" class is particularly intriguing as its members demonstrate physical symptoms of FA (i.e., tolerance and withdrawal) and psychological ones (i.e., craving and consequences) but are not as functionally impaired as the “fully addicted” class. Identifying different profiles according to FA symptoms holds potential value in providing tailored and timely interventions.
Effects of non-steroidal anti-inflammatory agents on systemic hemostasis during the most acute period of cold injury in rats
Authors: Shtrygol’ Sergiy , Taran Andrii , Yudkevych Tetiana , Lytkin Dmytro , Lebedinets Iryna , Chuykova Polina , Koiro Olga 
Published: January 2024

Non-steroidal anti-inflammatory drugs (NSAIDs) have recently been considered promising agents for the prevention and treatment of cold injuries. The results of previous studies demonstrate a distinct frigoprotective effect of diclofenac sodium and etoricoxib.
The aim of the study: to assess the impact of diclofenac sodium and etoricoxib, as the most effective frigoprotectors among NSAIDs, on coagulation indicators during the most acute phase of cold injuries using an acute model of general cooling in rats.
Materials and Methods: The experiment was carried out using 41 outbreed male rats weighing 310±10 g. Cold injury was induced by acute general cooling (exposure to –18 °C for 2 hours). Diclofenac sodium (7 mg/kg) and etoricoxib (5 mg/kg) were administered intragastrically 30 minutes before the onset of cold exposure. Rectal temperature was measured before and after cold exposure. Immediately after exposure, plasma was used to determine prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen levels, and in blood serum – the residual amount of prothrombin, thrombin, fibrinogen, as well as D-dimer using species-specific immunoenzymatic analysis kits.
Results: Etoricoxib and especially diclofenac sodium significantly reduced the degree of hypothermia (rectal temperature decreased by 1.3 % and 1.9 %, respectively, compared to a 5.4 % decrease in the control group, p < 0.05). In the acute phase of cold injury in the untreated control group, there was a significant increase in D-dimer (by 2.7 times) and fibrinogen content (by 1.9 times) in blood serum, alongside a 21.7 % increase in thrombin time, indicating a heightened risk of thrombus formation and DIC syndrome development. The other coagulation indicators did not show significant changes. Both diclofenac sodium and etoricoxib significantly reduced elevated D-dimer and serum fibrinogen, normalizing thrombin time and indicating an antithrombotic effect. There was no significant difference in the effect of both NSAIDs on blood coagulation status.
Conclusions: The acute phase of cold injury demonstrates a dangerous shift in blood coagulation towards thrombus formation and DIC syndrome development. Prophylactic use of diclofenac sodium and, to a lesser extent, etoricoxib displays an anti-hypothermic effect, reducing the risk of thrombosis and DIC syndrome. This proves the expediency of using these NSAIDs for acute cold injury
Exploring perceptions of students on safety and security from selected south African historically disadvantaged institutions
Authors: Lekganyane John Kgatla , Maluleke Witness , Barkhuizen Jaco 
Published: January 2024

Students from distinct regions and even abroad flock to campuses of Higher Education Institutions (HEIs) to broaden their knowledge in diverse fields of study. These institutions offer a wide array of academic, social and sports-related programs. However, safety remains a major concern for students worldwide. The increasing number of cases of victimization on and around campuses, including at the Historically Disadvantaged Institutions (HDIs), has necessitated the serious consideration of students' safety. This study aims to explore students' perceptions of safety, as it focuses on Two (02) South African HDIs, specifically focusing at Universities of Limpopo (UL) and Venda (UNIVEN) of South Africa. This study adopted the qualitative approach, employing the case study design, with the aid of exploratory objectives. About Twenty (20) participants were selected using the non-probability: Purposive sampling to take part in semi-structured, face-to-face interviews. The collected data were analysed using the inductive Thematic Content Analysis (TCA) with inductive reasoning.
The findings discovered that inadequate lighting in certain areas of the campus, insufficient Closed-Circuit Television (CCTV) in some student residences, the absence of police patrols around the campus, and the unavailability of emergency phones to contact security officials are factors that contribute to the feeling of insecurity in both on-campus and off-campus housing. The study also found that students are hesitant to travel alone at night, regardless of whether they are living on-campus or off-campus. Not surprisingly, the study found that students who reside off-campus are more afraid of sexual violence than those who reside in on-campus housing. With respect to recommendations, it is advised that it is necessary to install CCTVs in all leased off-campus accommodations as well as the on-campus residences to keep students secure. For students living off-campus, there should be enough transportation to help their movement to and from their respective homes. In addition, it is recommended that police patrols be visually evident on the campus as well as near off-campus accommodations where many students reside
Biological properties of macroporous cryostructurate based on extracellular matrix components
Authors: Grigoriev A. M. , Basok Yu. B. , Belova A. D. , Shmerko N. P. , Subbot A. M. , Kulakova V. K. , Lozinsky V. I. , Sevastianov V. I. 
Published: January 2024

Objective: to study the biological properties of macroporous cryostructurate from multicomponent concentrated collagen-containing solution (MCCS) as a promising matrix for the formation of cell- and tissue-engineered constructs.Materials and methods. A macroporous spongy carrier was obtained by cryostructuring of collagencontaining extract, prepared by acetic acid hydrolysis of chicken connective tissue (BIOMIR Service, Russian Federation). N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide (Sigma-Aldrich, USA) was used to make the cryostructurate water insoluble. The micromorphology of the sponge surface was studied using scanning electron microscopy. The cytotoxicity of the carrier was evaluated by reaction of the mouse NIH 3T3 fibroblast cell culture using automated microscope IncuCyte ZOOM (EssenBioscience, USA). Biocompatibility of the macroporous carrier was studied on cultures of human adipose tissue-derived mesenchymal stromal cells (AD-MSC), human hepatocellular carcinoma cell line HepG2 and human umbilical vein endothelial cell line EA.hy926. The metabolic activity of cells was determined using PrestoBlue™ reagents (Invitrogen™, USA). Cell population development during long-term cultivation of the cell-engineered construct (CEC) was assessed by fluorescencelifetime imaging microscopy over the entire surface of the sample using a Leica Dmi8 inverted microscope with Leica Thunder software (Leica Microsystems, Germany).Results. Optical microscopy and scanning electron microscopy (SEM) showed the presence of pores of different sizes in the resulting biopolymer material: large pores with 237 ± 32 μm diameter, medium-sized pores with 169 ± 23 μm diameter, and small-sized pores with 70 ± 20 μm diameter; large and medium-sized pores were predominant. The studied media did not exhibit cytotoxicity. Cell adhesion and proliferation on the surface of the material and their penetration into the underlying layers during long-term cultivation were observed. The highest metabolic activity of the cells was observed for human AD-MSC on day 14, which corresponds to the normal dynamics of development of a population of cells of this type. The functional activity of HepG2 cells – albumin and urea production – was shown in the liver CEC model.Conclusion. The good adhesion and active proliferation that were shown for the three cell types indicate that the resulting biopolymer carrier is biocompatible, and that the spread of the cells into the inner volume of the sponge and active population of the sponge under prolonged culturing indicates that this material can be used to create cell- and tissue-engineered constructs.
Successful two-stage transplant hepatectomy using the ALPPS procedure for advanced hepatocellular cancer
Authors: Granov D. A. , Zhuikov V. N. , Tileubergenov I. I. , Rutkin I. O. , Polikarpov A. A. , Sheraliev A.  R. , Rozdobara M. V. 
Published: January 2024

In the presented case, after liver transplantation (LT) for hepatocellular cancer (HCC), the disease progressed in the graft, left lung and bronchopulmonary lymph nodes after 16 months, according to the Milan criteria. Against the background of combined treatment – hepatic artery chemoembolization (HAC), systemic targeted therapy and stereotactic radiotherapy for metastatic node of the left lung – HCC in the extrahepatic foci was stabilized. In this situation, we considered resection of the liver transplant as the only therapeutic option that provides a chance for significant prolongation of the patient’s life. However, extensive resection of the right liver lobe seemed unsafe due to a number of limiting factors – borderline functional residual capacity of the remaining liver: future liver remnant (FLR), 599 cm3 (32%); plasma disappearance rate (PDR), 12.3%/min; tumor invasion of the middle hepatic vein basin. In this case, right portal vein branch (RPVB) embolization could promote vicarious hypertrophy of the remaining part of the liver, but the waiting period usually exceeds three to four weeks, and the RPVB was already partially blocked by the tumor at that time. The only option for surgical intervention was, in our opinion, two-stage hepatectomy according to the Associated Liver Partition and Portal Vein Ligation for Staged hepatectomy (ALPPS) procedure, despite the absence of literature data on the performance of such operations on a liver transplant. On postoperative day 5 from the first stage, a 799 cm3 FLR hypertrophy was achieved, which allowed to perform the second stage of intervention relatively safely. Competent tactics regarding medication in the intensive care unit (ICU) and renal replacement therapy allowed to cope with sepsis and acute renal failure – the prevailing postoperative complications.
Clinical case of recurrent aHUS after allogeneic cadaveric kidney transplantation
Authors: Popov S. V. , Esayan A. M. , Guseynov R. G. , Orlov I. N. , Lomonosova E. V. , Perepelitsa V. V. , Vorobyeva О. A. , Sadovnikova A. V. , Lelyavina T. A. 
Published: January 2024

Introduction. Atypical hemolytic uremic syndrome (aHUS) is a systemic orphan disease that reproduces as an uncontrolled activation of the alternative pathway of the complement system and is expressed as systemic thrombotic microangiopathy (TMA). The classical triad of aHUS symptoms are hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI). Currently, diagnosis of aHUS is a diagnosis of exclusion and has no pathognomonic features. It is established based on the clinical presentation of the disease after excluding other forms of TMA, Objective: to increase physicians’ awareness of this rare disease, the diagnosis and treatment of aHUS using a clinical case study.Conclusion. Early diagnosis of aHUS is extremely important, as timely targeted therapy can significantly improve or completely restore the functions of the affected organ.
Donor-derived myeloid sarcoma in a kidney transplant recipient: clinical case study and relevance of a multidisciplinary approach in therapy and diagnosis
Authors: Chichagova N. A. , Gogolev D. V. , Kuzmin D. O. , Ananyev A. N. , Kutenkov A. A. , Galkin A.  A. , Kapitulskaya T.  B. , Fedotova D. D. , Ulyankina I. V. , Reznik O. N. , Bagnenko S. F. 
Published: January 2024

Background. Malignant tumors are one of the main causes of unfavorable outcomes in solid organ transplant recipients in the long term after transplantation. Localization of these tumors in a transplanted organ may cause loss of graft function. After chronic graft dysfunction and infections, malignant neoplasms come next as one of the leading causes of late kidney graft loss. The incidence of different types of malignancies varies according to the transplanted organ. Knowledge of etiology, pathogenesis, peculiarities of diagnosis and treatment of malignant tumors in solid organ transplant recipients is a significant part of screening at any stage of post-transplant period. Late diagnosis of malignancies in a transplanted kidney amidst disconnected stages of treatment and follow-up leads not only to graft loss, but also jeopardizes the life of recipients.Clinical case description. The patient is a 29-year-old female. History: IgA nephropathy with nephrosclerosis. Renal replacement therapy (RRT) with long-term hemodialysis since March 2019. Kidney transplantation from a deceased donor to the right external iliac vessels on March 13, 2019. Graft function is immediate. In October 2020, a tumor in the transplanted kidney was detected for the first time. In November 2021, an emergency graft nephrectomy was performed for health reasons. Antibacterial, antifungal therapy was carried out. Results of morphological study of the removed renal graft with immunohistochemistry (IHC) were obtained. The structure and phenotype of the tumor are consistent with myeloid sarcoma. Trephine biopsy: normocellular bone marrow.Conclusion. The 29-year-old patient was diagnosed with donor-derived myeloid sarcoma in her kidney transplant with the development of paraneoplastic syndrome and multi-organ failure. Currently, the patient is receiving RRT by long-term scheduled hemodialysis. Organ recipients need to be managed by a multidisciplinary team of specialized and highly specialized specialists, taking into account comorbid status and features of the course of the underlying disease.
Lecturers’ Efficacy and Readiness towards Utilization of ICT for Academic Research in College of Education
Authors: Odefunsho Olukayode Amos , Oladimeji Rasheedat Modupe , Bolaji Hammed Olalekan , Akinnubi Olaolu Paul 
Published: January 2024

The study investigated Lecturers’ Efficacy and Readiness towards the Utilization of ICT for Academic Research in the College of Education in Kwara State. Non-experimental research design involving a descriptive survey was adopted. The instrument used for data collection was a questionnaire. The instruments were given to three experts in Science Education, Test, Measurement, and Evaluation. ICT experts who determined the validity of the instrument. The lecturers' Efficacy, lecturers' readiness, and lecturers utilizations were measured through a questionnaire. The population of the study was all the lecturers in the two Colleges of Education used as case studies comprising state and private colleges of education. The study also made use of 140 academic staff in both colleges of Education adopting Krejcie and Morgan, 1970 i.e. Kwara State College of Education, Ilorin (153 participants) while Kwara State College Of Arabic and Islamic Legal Studies Ilorin Kwara State (52 participants) Structured questionnaire titled: “Lecturers’ Efficacy and Readiness towards Utilization of ICT Questionnaire” (LERUQ) was used to elicit information. Descriptive statistics of the frequency and percentage were used to answer research questions while Pearson Product Moment Correlation (PPMC) was used to test the research hypotheses formulated in the study at a 0.05 level of significance. The findings showed most of the lecturers’ had positive reactions towards it, limited knowledge, and limited understanding.
Кому потребовалась «перестройка»? «Застоя» не было!
Authors: Ильинский Игорь Михайлович 
Published: January 2024

<p>Статья известного социального философа ректора Московского гуманитарного университета И. М. Ильинского представляет собой вариант текста главы в книге о «перестройке», над которой автор работает уже многие годы. Данный текст продолжает тему предыдущих статей И. М. Ильинского, опубликованных в журнале «Знание. Понимание. Умение». В данной статье на основе большого количества исторических источников и архивных материалов рассказывается о том, что так называемый застой в советской экономике 1980-х гг. — не более чем миф. На самом деле, как показывает автор статьи, страна в этот период экономически развивалась, хотя сложно и противоречиво. При этом само развитие было обусловлено внедрением в экономику страны элементов рынка, регулируемого государством. В то же время экономическая и политическая катастрофа перестройки была связана не столько с кризисом советской системы (которая была вполне реформируема), сколько с рядом правительственных мер конца 1980-х гг., направленных на введение в стране нерегулируемого рынка. Тяжелый экономический кризис, вызванный этими мерами, усугубился целенаправленной политикой руководства США, направленной на развал Советского государства. Автор статьи еще раз утверждает в этой публикации, что за всеми этими негативными процессами в политике и экономике стоял заговор руководителей государства (М. С. Горбачева, А. Н. Яковлева, Э. А. Шеварднадзе).</p><div> </div>
Tuberculous otomastoiditis: analysis of otological tuberculosis with intact tympanic membrane
Authors: Gupta Nandini , Sharma Divyanshu , Parikh Darshan 
Published: January 2024

In recent years extra pulmonary tuberculosis has more frequently been associated with mastoiditis in patients with immunodeficiency state. Although tuberculosis of the mastoid or otomastoiditis is a very rare complication of tuberculosis today, when occurs it may cause significant morbidity. Complications such as facial paralysis and permanent hearing loss may develop. Our purpose was to evaluate the differential findings of tuberculous otomastoiditis and evaluation of outcomes in patients undergoing surgery along with anti-tubercular therapy rather than patients receiving only anti-tubercular therapy. We reviewed 12 cases of TOM, all of which had been confirmed on sputum and pathological examination following middle ear mucosal biopsy. Neuroradiologists analyzed the typical findings of HRCT temporal bone. Tympanomastoid ear surgery was planned according to the extent of the disease involved. The soft tissue attenuation in the entire middle ear cavity and extension to the external auditory canal (EAC) or mucosal thickening of the bony EAC, erosion of the ossicles and scutum was clinically significant. Patients who underwent tympanomastoid surgery showed better prognosis than the patients receiving anti tubercular drugs alone. Patients with extra-pulmonary tuberculosis, especially otomastoiditis should get operated to remove the disease along with anti-tubercular treatment to prevent complications.