bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐resolution nerve ultrasound and corneal confocal microscopy in taxane‐induced polyneuropathy
Authors: Katz Maria , Mork Hannah , Baghdasaryan Nazik , Hesse Lukas , Wille Kai , Treichel Jasmin , Motte Jeremias , Klimas Rafael , Sturm Dietrich , Schellinger Peter Dieter , Hettlich Hans‐Joachim , Philipps Jörg 
Published: November 2023

AbstractBackground and purposeThe role of high‐resolution nerve ultrasound (HRUS) and corneal confocal microscopy (CCM) in the early detection of taxane‐induced polyneuropathy (TIPN) is unclear. The present prospective longitudinal controlled observational pilot study estimates the role of HRUS and CCM in the early diagnosis of TIPN in breast cancer patients.MethodsFifteen breast cancer patients receiving paclitaxel and 15 healthy age matched controls were included. Visits before and 3 weeks, 8 weeks and 6 months after treatment included clinical examination, the total neuropathy score, nerve conduction studies (NCS), monocular CCM including corneal nerve fibre length, density and branching and HRUS of bilateral median, ulnar, radial, tibial, peroneal and sural nerves. Patients were compared between different visits and to healthy controls.ResultsTotal neuropathy score increased from 2.2 at baseline to 5.8 (p < 0.001) at week 8. NCS showed a decreased sensory amplitude in the sural, radial, ulnar and median nerve after 6 months (p < 0.001). HRUS revealed a significant increase of cross‐sectional area in the sural nerve (p = 0.004), the median nerve (p = 0.003) at the carpal tunnel and the ulnar nerve in the forearm (p = 0.006) after 6 months. CCM showed no changes at different visits.ConclusionsCorneal confocal microscopy and HRUS do not detect early signs of TIPN during the paclitaxel treatment period. HRUS and NCS might detect congruent signs of an axonal, predominantly sensory polyneuropathy after 6 months. The clinical examination remains the most sensitive tool in the early detection of TIPN in breast cancer patients.
Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini‐review on availability and limitations
Authors: Berezowska Monika , Sharma Pradeep , Pilla Reddy Venkatesh , Coppola Paola 
Published: November 2023

AbstractPhysiologically based pharmacokinetic (PBPK) modelling in pregnancy is a relatively new approach that is increasingly being used to assess drug systemic exposure in pregnant women to potentially inform dosing adjustments. Physiological changes throughout pregnancy are incorporated into mathematical models to simulate drug disposition in the maternal and fetal compartments as well as the transfer of drugs across the placenta. This mini‐review gathers currently available pregnancy PBPK models for drugs commonly used during pregnancy. In addition, information about the main PBPK modelling platforms used, metabolism pathways, drug transporters, data availability and drug labels were collected. The aim of this mini‐review is to provide a concise overview, demonstrate trends in the field, highlight understudied areas and identify current gaps of PBPK modelling in pregnancy. Possible future applications of this PBPK approach are discussed from a clinical, regulatory and industry perspective.
Theses and dissertations completed in family and consumer sciences: 2022
Authors: Alexander Karen L. , Hinson Jacinta D. 
Published: November 2023

AbstractSince 1992, completion of graduate student degrees and research in family and consumer sciences has been collected annually. Data collection for 2022 began in July 2023 when 549 e‐mail invitations were sent to contacts at 165 U.S. universities and colleges inviting family and consumer sciences programs to report graduate program degree completions and research production through theses and dissertations. Twenty‐three institutions responded with data. They reported 740 graduate degrees conferred collectively with 123 master's theses, 184 dissertations, and 433 non‐thesis master's degrees completed. This report presents submitted information on theses and dissertations organized into 17 subject‐matters categories and listed by degree level.
Family and consumer sciences graduate research productivity in 2022
Authors: Alexander Karen L. , Hinson Jacinta D. 
Published: November 2023

AbstractSince 1992, information on graduate student degrees and family and consumer sciences research has been collected annually. Data collection for 2022 began in July 2023 when 549 e‐mail invitations were sent to contacts at 165 U.S. universities and colleges, inviting family and consumer sciences programs to report graduate program degree completions and research production through theses and dissertations. Twenty‐three institutions responded with data and reported 740 graduate degrees conferred collectively, with 123 master's theses, 184 dissertations, and 433 non‐thesis master's degrees completed. This review reports degree completion and highlights topical trends of the theses and dissertations completed by reporting programs.
Contrasting effects of frugivore assemblages and phylogeny on global variation in fruit length and width
Authors: Yu Fei , Zhang Mingming , Wang Yang , LaMontagne Jalene M. , Yi Xianfeng 
Published: November 2023

AbstractAimThe evolution of fruit size is poorly understood, though long‐standing hypotheses, the dispersal syndrome hypothesis and correlated evolution hypothesis, have highlighted the influence of frugivores and phylogeny on fruit size variation.LocationInteraction networks were extracted from studies carried out in Asia, Europe, Africa, Hawaii, Australia, New Zealand and the Neotropics.Time PeriodUp to 50 years between 1970 and 2022.Major Taxa StudiedFrugivores (birds and mammals) and fleshy‐fruited plants.MethodsWe compiled a global data set on fruit size (i.e. width and length) and plant traits (i.e. leaf area and plant height) for 349 fleshy‐fruited plants, and the body mass of frugivores from 326 interaction networks. We constructed a plant phylogeny from a mega‐tree containing 74,533 vascular plant species and we calculated Pagel's λ to assess the phylogenetic signal in plant traits and fruit size. Phylogenetic generalized linear mixed model (PGLMM) was used to reveal relationships between fruit size and plant traits as well as the body mass of interacting frugivores. We used phylogenetic partial R2s regression model to tease apart the effects of body mass of frugivores, leaf area, plant height and plant phylogeny on the evolution of fruit size.ResultsWe show that the global variation in fruit width is better explained by frugivorous assemblages than by phylogeny and plant functional traits (leaf area and plant height). Despite the significant evolutionary correlation between fruit length and width, fruit length appears to be more phylogenetically constrained and less sensitive to frugivore‐driven selection than fruit width.Main ConclusionIn light of the two original hypotheses, our study demonstrates a global phylogenetic constraint on fruit length and frugivore‐driven selection on fruit width, provides a novel mechanistic explanation for the evolution of fruit size across fleshy‐fruited plant species. Our findings contribute to a deeper understanding of the complex interplay between frugivory, phylogeny and plant traits in the evolution of fruit size, offering valuable insights into the broader context of published findings and hypotheses in this field.
PHENOMENOLOGY OF DIVINE REVELATION: THEOLOGY AND PHILOSOPHY IN DIALOGUE
Authors: Kim Junghyung 
Published: November 2023

AbstractAlthough the relationship between theology and philosophy is a perennial issue in the history of thought, recent debates surrounding the so‐called theological turn of continental phenomenology have created a new space in which it can be explored from a fresh perspective. In this vein, I propose three theses concerning the relationship between theology and philosophy of religion, with particular focus on the phenomenon of divine revelation. First, a philosophy of religion that ignores theology's claim about divine self‐revelation will remain incomplete and unsatisfactory, at least from the perspective of a Christian theology which begins with the faith in God's self‐revelation in one particular human person. Second, a theology that does not acknowledge the possibility of philosophical reflections on the human aspect of divine revelation will not be able to escape blind dogmatism, but rather will isolate itself from the academic community. Third, and finally, despite the concerns of both parties, a dialogue between theology and philosophy centred on the phenomena of revelation can develop into mutually critical and mutually constructive interactions.
Electoral turnout of foreign‐born residents in Chile: an analysis with data from the administrative census and opinion polls
Authors: Herrera Mario , Morales Mauricio 
Published: November 2023

AbstractBased on an administrative census of the 267,116 migrants registered for the 2017 presidential elections and a survey applied to 4771 migrants, we conclude that (1) the electoral participation of migrants shows a significant gender gap, with women participating in a higher proportion; (2) migrants who registered earlier in the electoral registers, are more likely to vote compared to the rest; (3) when migrants come from countries that implement compulsory voting, they increase their likelihood of voting in the receiving country; (4) the declaration of wanting to remain in Chile and not return to their countries of origin or migrate to another country increases the probability of voting, and the same happens with married migrants, with Chilean children, with a Chilean partner, and with a better economic situation; (5) social capital has a positive influence on electoral participation.
Periodontitis and the risk of all‐cause and cause‐specific mortality among US adults with diabetes: A population‐based cohort study
Authors: Li Weiqi , Peng Jiakuan , Shang Qianhui , Yang Dan , Zhao Hang , Xu Hao 
Published: November 2023

AbstractAimTo evaluate the association between periodontitis, all‐cause and cause‐specific mortality, and its prognostic utility among adults with diabetes.Materials and MethodsPeriodontal health records were retrieved from the NHANES database for 4297 participants with diabetes aged >30 years at baseline during 1988–1994, 1999–2004 and 2009–2014. Multivariable Cox proportional hazards regression model was applied to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for moderate/severe periodontitis with all‐cause and cause‐specific mortality in participants with diabetes. Area under the curve (AUC) was used to assess predictive value.ResultsDuring a median follow‐up of 15.41 years, 1701 deaths occurred. After multivariate adjustments, moderate/severe periodontitis was significantly associated with increased risk of all‐cause (HR: 1.27; 95% CI: 1.07–1.50; p = .005) and cardiovascular disease (CVD)‐related (HR: 1.35, 95% CI: 1.03–1.76, p = .031) mortality in participants with diabetes. The absolute risk difference based on the cumulative incidence information was 0.022 (5‐year, 95% CI: 0.021–0.023) and 0.044 (10‐year, 95% CI: 0.041–0.048). Periodontitis improved the prediction of all‐cause (AUC: 0.652; 95% CI: 0.627–0.676) and CVD‐related (AUC: 0.649; 95% CI: 0.624–0.676) mortality over standard risk factors (all‐cause: AUC: 0.631; 95% CI: 0.606–0.656; CVD‐related: AUC: 0.629; 95% CI: 0.604–0.655).ConclusionsModerate/severe periodontitis is associated with an increased risk of all‐cause and CVD‐related mortality in adults with diabetes. Periodontitis might represent a marker for residual risk.
Frequency of colorectal surveillance colonoscopies for adenomatous polyps: systematic review and meta‐analysis
Authors: Ho Yiu Ming , Merollini Katharina M D , Gordon Louisa G. 
Published: November 2023

AbstractBackground and AimThe purpose of this study was to assess evidence on the frequency of polyp surveillance colonoscopies performed earlier than the recommended follow‐up intervals in clinical practice guidelines.MethodsA systematic review was performed based on electronic searches in PubMed and Embase. Research articles, letters to the editors, and review articles, published before April 2022, were included. Studies that focused on the intervals of polyp surveillance in adult populations were selected. The Risk Of Bias In Non‐randomized Studies of Exposure (ROBINS‐E) was used to assess the risk of bias. A meta‐analysis was performed with Forest plots to illustrate the results.ResultsIn total, 16 studies, comprising 11 172 patients from Australia, Europe, and North America, were included for analysis. The quality of the studies was moderate. Overall, 38% (95% CI: 30–47%) of colonoscopies were undertaken earlier than their respective national clinical guidelines. In risk‐stratified surveillance, 10 studies contained data relating to low‐risk polyp surveillance intervals and 30% (95% CI: 29–31%) of colonoscopies were performed earlier than recommended. Eight studies contained data relating to intermediate‐risk polyp surveillance and 15% (95% CI: 14–17%) of colonoscopies were performed earlier than recommended. One study showed that 6% (95% CI: 4–10%) of colonoscopies performed for high‐risk polyp surveillance were performed earlier than recommended.ConclusionsA significant proportion of polyp surveillance was performed earlier than the guidelines suggested. This provides evidence of the potential overuse of healthcare resources and the opportunity to improve hospital efficiency.
Skin rejuvenation effect of the combined PDLLA and non cross‐linked hyaluronic acid: A preliminary study
Authors: Seo Suk Bae , Park Hyunwoo , Jo Ju Young , Ryu Hwa Jung 
Published: November 2023

AbstractBackgroundSkin aging is characterized by wrinkles, rough skin texture, pigmentation, facial erythema, and telangiectasia through structural and functional changes in the epidermis and dermis. Recently, injectable poly(D, L‐lactic acid), a biodegradable polymer, has been used widely for skin rejuvenation.AimsThis study aims to assess the efficacy and safety of injectable dermal poly D, L‐lactic acid) for skin rejuvenation.Patients/MethodsA total of 16 patients who desired skin rejuvenation were included. All participants received two or three procedure sessions with a 4 weeks interval between sessions. Clinical and three‐dimensional images at baseline, before each procedural session, and follow‐up visits were obtained. Therapeutic effects were assessed by evaluating signs of aging skin and overall improvement by dermatologists and patients. Histologic examinations with special stains were performed on the posterior auricular areas of consenting patients at baseline and follow‐up visits after injecting poly D L‐lactic acid into the postauricular area as in the face.ResultsOverall, statistically significant differences were observed in all signs of aging skin, such as fine wrinkles, skin texture, irregular pigmentation, telangiectasia, and facial erythema before and after treatments. Half (50%) of patients responded that there was more than 50% overall improvement. There were no severe adverse events. Histologic examination demonstrated increases in collagen and elastic fibers in the dermis.ConclusionsResults of this preliminary study suggest that injectable dermal poly D, L‐lactic acid can significantly affect skin rejuvenation without causing any serious adverse events.
Individualized multidisciplinary therapy for vulvodynia
Authors: Penteado Sonia Regina Lenharo , Bonduki Claudio Emilio , de Araújo Teresa Raquel Embiruçu , Alves Suzana Valeska , de Luccas Batista Nina Morena Teixeira , Ambrogini Carolina Carvalho , Sartori Marair Gracio Ferreira 
Published: November 2023

AbstractObjectiveThe main objective of this review was to develop strategies for individualizing multidisciplinary therapy for vulvodynia.MethodsWe conducted two literature searches; the first one focused on clinical trials assessing vulvodynia treatments published after the recommendations of the expert committee of the Fourth International Consultation on Sexual Medicine. The second search targeted studies identifying predictive factors and mediators of vulvodynia treatments, published from the earliest date to October 2022.ResultsBased on data from 55 relevant studies, we developed models of individualized multidisciplinary therapy targeting groups of women less responsive to multidisciplinary therapy (characterized by women with higher vulvar pain intensity, impaired sexual functioning, and vulvodynia secondary subtype) and to physical therapy, as an isolated treatment (characterized by women with increased pelvic floor muscle tone and vulvodynia primary subtype). Each individualized multidisciplinary therapy model comprises three components: psychotherapy, medical care, and physical therapy. These components provide distinct therapeutic modalities for distinct subgroups of women with vulvodynia; the women subgroups were identified according to the characteristics of women, the disease, partners, and relationships. Additionally, for women with provoked vestibulodynia who exhibit less benefits from vestibulectomy (such as those with higher levels of erotophobia, greater vulvar pain intensity, and the primary subtype) and encounter resistance to individualized multidisciplinary therapy, we suggest additional conservative treatments before performing vestibulectomy.ConclusionOur study is a pioneer in the development of models that allow the individualization of multidisciplinary therapy for vulvodynia and represents a significant advance in the clinical practice of gynecologists, physiotherapists, and psychologists.
Ovarian fibromatosis associated with large pedunculated fibroma in a 30‐year‐old woman: A rare coincidence or variant?
Authors: Takeda Akihiro , Watanabe Kazuko , Koike Wataru 
Published: November 2023

AbstractA 30‐year‐old nulligravida was referred under suspicion of large subserosal myoma. T2‐weighted magnetic resonance imaging revealed multilobulated solid mass in the left lower abdomen measuring 16 cm in longitudinal diameter. The ovarian surface was covered with a marked T2‐hypointense thick rim called “black garland sign,” forming multiple nodular masses ranging from 1 to 5 cm in diameter in some portions of the bilateral ovaries. By laparoscopic‐assisted minilaparotomy, the stalk of pedunculated mass originating from the left ovarian hilum was excised, followed by carrying out of the body after in‐bag morcellation using a surgical scalpel. Right ovarian exophytic nodular masses larger than 1 cm were excised using monopolar electrode needle. Pathological examination of excised right and left masses showed fibroblast‐like spindle cell proliferation with collagenous stroma; however, differences between right and left masses cannot be distinguished on a histological level. Postoperative diagnosis was ovarian fibromatosis coexisting with large pedunculated fibroma.
The correlation between death anxiety, loneliness and hope levels in patients treated in the cardiac intensive care unit
Authors: Yildirim Dilek , Akman Ozlem , Ozturk Serpil , Yakin Ozlem 
Published: November 2023

AbstractBackgroundA sense of hope plays an important role in relieving stress and psychological distress of cardiology patients, as well as improving their physical well‐being.AimThe aim of this study is to investigate the correlation between death anxiety, loneliness and hope levels in patients receiving treatment in a cardiac intensive care unit (ICU).DesignThis is a prospective, descriptive and correlational study.MethodsThe study was completed with 150 cardiac ICU patients in Istanbul, Turkey. The data were collected using a Patient Information Form, the Templer Death Anxiety Scale (TDAS), the Herth Hope Index (HHI) and the UCLA Loneliness Scale (UCLA‐LS).ResultsThe patients had a mean age of 63.56 ± 12.74 years. Most of the patients (82%) were treated in the ICU for heart failure. There was a statistically significant positive correlation between total scores of TDAS and UCLA‐LS (r = .337; p < .001) and a statistically significant negative correlation between total scores of UCLA‐LS and HHI (r = −.292; p < .001). Also, there was a statistically significant negative correlation between the scores of UCLA‐LS and Positive Readiness and Expectancy Subscale (r = −.164; p = .044). The multiple linear regression indicated that the model was statistically significant (F = 7.177, p < .001). The variables of age and UCLA‐LS among those included in the model were statistically significant predictors of the death anxiety scores of the patients (23.1%) (p < .05).ConclusionsThe cardiology patients who received treatment in the ICU had a high level of death anxiety and moderate levels of loneliness and hope. The age and loneliness level were statistically significant predictors of death anxiety.Relevance to Clinical PracticeIt is recommended that individualized nursing care be planned and provided to conscious cardiology patients who are treated in the ICU, considering their age and loneliness levels and that nursing care be planned for individuals who are at risk of fear, anxiety, loneliness and hopelessness by periodically assessing their death anxiety, loneliness and hope levels.
Erector spinae plane blocks: A narrative update
Authors: Bosenberg Adrian 
Published: November 2023

AbstractThe erector spinae plane block (ESPB) is perhaps one of the most interesting of the tissue plane blocks described recently. There has been an exponential increase in the number of publications for both adults and children over the past 5 years. Single‐shot, intermittent bolus, and continuous infusion techniques have been used effectively. Both the efficacy and safety of the procedure are widely accepted, but the exact mechanism by which the local anesthetic spreads from the tip of the transverse process to block the dorsal and ventral rami of the spinal nerves is controversial and needs clarification. Anatomical differences in children, particularly in neonates and infants, may explain the spread in this age group. In most pediatric studies, erector spinae plane block was opioid sparing, and noninferiority was observed when compared with other regional techniques.
Differential efficacy with epidural blood and fibrin patches for the treatment of post‐dural puncture headache
Authors: López‐Millán José M. , Fernández Antonio Ordóñez , Fernández Jorge Muriel , Dueñas Díez José L. 
Published: November 2023

AbstractBackgroundAccidental dural puncture (ADP) is the most frequent major complication when performing an epidural procedure in obstetrics. Consequently, loss of pressure in the cerebrospinal fluid (CSF) leads to the development of post‐dural puncture headache (PDPH), which occurs in 16%–86% of cases. To date, the efficacy of epidural fibrin patches (EFP) has not been evaluated in a controlled clinical trial, nor in comparative studies with epidural blood patches (EBP).MethodsThe objective of the present study was to compare the efficacy of EFP with respect to EBP for the treatment of refractory accidental PDPH. This prospective, randomized, open‐label, parallel, comparative study included 70 puerperal women who received an EBP or EFP (35 in each group) after failure of the conventional analgesic treatment for accidental PDPH in a hospital.ResultsA higher percentage of women with EFP than EBP achieved complete PDPH relief after 2 (97.1% vs. 54.3%) and 12 h (100.0% vs. 65.7%) of the patch injection. The percentage of patients who needed rescue analgesia was significantly lower with EFP after 2 (2.9% vs. 48.6%) and 12 h (0.0% vs. 37.1%). After 24 h, PDPH was resolved in all women who received EFP. The recurrence of PDPH was reported in one woman from the EBP group (2.9%), who subsequently required a second patch. The mean length of hospital stay was significantly lower with EFP (3.9 days) than EBP (5.9 days). Regarding satisfaction, the mean value (Likert scale) was significantly higher with EFP (4.7 vs. 3.0).ConclusionsEFP provided better outcomes than EBP for the treatment of obstetric PDPH in terms of efficacy, safety, and patient satisfaction.