bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can responsible leaders transmute sustainability & OCBE among manufacturers in developing economy? A mediated moderated approach for organizational sustainability
Authors: Wang Guohua , Ain Aslam Qurat ul , Mushtaq Naveed , Liaqat Ayesha , Asmi Fahad 
Published: January 2025

Abstract
This study examined the link among environmentally conscious organizational citizenship behavior (OCBE) and responsible leadership among 167 management-level workers in manufacturing plants of arts industry in a developing economy. The study explored the impact of responsible leadership on OCBE, both directly and indirectly through colleague exchange. It also explored the role of a green organizational environment, employee goal orientation, and supervisory support in regulating the link between coworker exchange and OCBE. The findings indicated that responsible leadership held a substantial and favorable influence on organizational citizenship behavior and that this link was mediated via colleague interchange. Workers who exhibited high degrees of goal orientation and were exposed to a sustainable work environment exhibited higher organizational citizenship behavior towards the environment (OCBE), suggesting a connection between colleague contact and OCBE. However, the support from supervisors did not have any moderating effect on this association. The study offers practical and management insights into how to encourage eco-behavior in the workplace.
Experimental paradigm to test the effects of providing social support: study protocol of the PROSPECT trial (Study 2)
Authors: Hajak Vivien , Grimm Simone , Gruszczyńska Ewa , Kroemeke Aleksandra , Józefacka Natalia , Warner Lisa Marie 
Published: January 2025

Abstract

Background
A growing body of research suggests that the provision of social support can have benefits not only for the recipients but also for the provider. Although initial evidence for affective, self-evaluative and physiological outcomes has been established, the beneficial effects of support provision do not occur consistently across all support interactions, and some interactions may even have detrimental effects on providers. The aim of our experimental paradigm is to enable researchers to test the conditions under which the provision of social support to dyadic partners affects affective, self-evaluative, physiological, and relationship outcomes for the provider. In line with self-determination theory, it is proposed that the provision of support is only beneficial to the provider if it satisfies the three basic psychological needs of autonomy, competence and relatedness. The paradigm allows for the manipulation of the provider's levels of competence (feedback on the effectiveness of their support to the other person) and relatedness (feedback on the alleged level of relatedness perceived by the partner person following the provision of support).

Methods
A priori power analyses resulted in a planned sample size of 250 participants randomized to four conditions: 1) no support provision, 2) support provision without feedback, 3) support provision with feedback on competence, 4) support provision with feedback on relatedness. Primary outcomes are immediate physiological (saliva cortisol, heart rate, heart rate variability, blood pressure), affective (positive and negative affect, anxiety), self-evaluative (e.g., self-esteem) and relationship outcomes. Generalized linear models will be used to compare the four conditions.

Discussion
In a controlled laboratory experiment, this new experimental paradigm manipulates the conditions under which social support is provided. Insights into the conditions under which the provision of social support is detrimental or beneficial to the provider can inform the development of preventive and interventional approaches across a range of life domains, motivational and developmental research across the lifespan (e.g. prevention of care-giver burnout), and applied clinical contexts (e.g. therapeutic interventions).

Trial registration
Pre-registration (2023-11-10): https://doi.org/10.17605/OSF.IO/8SPZW, retrospective registration with more details (2024-10-23): https://www.drks.de/DRKS00034287
Adverse childhood experiences, sleep quality/duration and later-life lower extremity function among older adults in China: evidence from CHARLS
Authors: Xiao Jiaqiang , Dong Xiaosheng , Ding Meng , Kong Tao 
Published: January 2025

Abstract

Objective
This study aimed to explore the relationship between adverse childhood experiences (ACEs), sleep, and lower extremity function in older adults using a nationally representative cohort.

Methods
This study included 4,439 participants aged 60 years or older (mean age: 67.2 ± 5.7 years) from the China Health and Retirement Longitudinal Study (CHARLS) 2015 national survey and the 2014 Life History Survey. ACEs, sleep duration, and sleep quality were assessed through self-report, and lower extremity function was measured using the Short physical performance battery (SPPB). The relationships between ACEs, sleep, and lower extremity function were analyzed using multivariate linear regression model and restricted cubic splines.

Results
After adjusting for covariates, older adults with four or more ACEs exhibited worse lower extremity function compared to those with no ACEs (β: -0.175). 6–8 h of sleep was associated with improved lower extremity function (β: 0.119), while good sleep quality was also associated with higher lower extremity function scores (β: 0.177). Age-related differences revealed that the association between four or more ACEs and reduced lower extremity function (β: -0.431) was significant only in individuals aged 70 years and older. In the 60–69 years age group, the sleep duration of 6–8 h was significantly related to better lower extremity function (β: 0.150), however, in those aged 70 years and older, more than 8 h of sleep was associated with poorer function (β: -0.378). Furthermore, good sleep quality was associated with better lower extremity function in individuals aged 70 years and older (β: 0.246).

Conclusion
ACEs, particularly household mental illness and parental disability, are associated with poorer lower extremity function in older adults. Normal sleep duration and good sleep quality are linked to better lower extremity function and may mitigate the negative effects of ACEs. However, these associations vary by age.
Assessing the impact of climate and land use change on flood vulnerability: a machine learning approach in coastal region of Tamil Nadu, India
Authors: Abijith Devanantham , Saravanan Subbarayan , Parthasarathy K S S , Reddy Nagireddy Masthan , Niraimathi Janardhanam , Bindajam Ahmed Ali , Mallick Javed , Alharbi Maged Muteb , Abdo Hazem Ghassan 
Published: January 2025

Abstract
Flooding and other natural disasters threaten human life and property worldwide. They can cause significant damage to infrastructure and disrupt economies. Tamil Nadu coast is severely prone to flooding due to land use and climate changes. This research applies geospatial tools and machine learning to improve flood susceptibility mapping across the Tamil Nadu coast in India, using projections of Land Use and Land Cover (LULC) changes under current and future climate change scenarios. To identify flooded areas, the study utilised Google Earth Engine (GEE), Sentinel-1 data, and 12 geospatial datasets from multiple sources. A random forest algorithm was used for LULC change and flood susceptibility mapping. The LULC data are classified for the years 2000, 2010, and 2020, and from the classified data, the LULC for years 2030, 2040, and 2050 are projected for the study. Four future climate scenarios (SSP 126, 245, 370, and 585) were used for the average annual precipitation from the Coupled Model Intercomparison Project 6 (CMIP6). The results showed that the random forest model performed better in classifying LULC and identifying flood-prone areas. From the results, it has been depicted that the risk of flooding will increase across all scenarios over the period of 2000–2100, with some decadal fluctuations. A significant outcome indicates that the percentage of the area transitioning to moderate and very high flood risk consistently rises across all future projections. This study presents a viable method for flood susceptibility mapping based on different climate change scenarios and yields estimates of flood risk, which can provide valuable insights for managing flood risks.
Toxic epidermal necrolysis with thrombocytopenia induced by intravenous immunoglobulin: a case report and mini review
Authors: Nishita Yoshihiro , Taga Masatoshi , Arakawa Nozomi , Ishida Tomoki , Ochiai Sawako , Ono Hiroto , Taga Fumiaki , Masauji Togen 
Published: January 2025

Abstract

Background
Toxic epidermal necrolysis (TEN), a severe cutaneous hypersensitivity reaction induced particularly by drugs, is diagnosed when there is a fever of ≥ 38 °C, mucocutaneous symptoms, a rash with multiple erythema, and skin peeling of ≥ 30% of the body surface area. The mortality rate of TEN is high, and thrombocytopenia during treatment can lead to severe outcomes. Intravenous immunoglobulin (IVIg) is used when steroids are ineffective in TEN and may improve mortality; however, thrombocytopenia is a rare adverse event associated with IVIg use. We report the case of thrombocytopenia during IVIg therapy for TEN. We also reviewed previous reports to learn more about the clinical course and mechanism of IVIg-induced thrombocytopenia.

Case presentation
An 83-year-old man with end-stage renal failure on hemodialysis was diagnosed with TEN. After an inadequate response to pulse methylprednisolone therapy, IVIg (400 mg/kg/day) was administered for 5 days. He developed thrombocytopenia after IVIg administration, leading to the diagnosis of thrombocytopenia due to IVIg after excluding other diseases. The platelet count began to increase approximately 10 days after IVIg administration.

Conclusions
When IVIg is administered for TEN, the risk of thrombocytopenia should be recognized and the platelet count should be carefully monitored.
Acute Concurrent Exercise Improves Inhibitory Control Without Mediating the Role of Lactate: An Event-Related Potential Study
Authors: Li Ruei-Hong , Chen Tai-Rui , Gilson Nicholas D. , Brazaitis Marius , Cheng Yi-Ting , Wu Hui-Fang , Lee Ji-Hang , Chang Yu-Kai 
Published: January 2025

Abstract

Background
Concurrent exercise (CE), an emerging exercise modality characterized by sequential bouts of aerobic (AE) and resistance exercise (RE), has demonstrated acute benefits on executive functions (EFs) and neuroelectric P3 amplitude. However, the effect of acute CE on inhibitory control, a sub-component of EFs, and P3 amplitude remains inconclusive. Moreover, exploring the mechanisms underlying the effects of acute exercise on EFs contributes to scientific comprehension, with lactate recognized as a crucial candidate positively correlated with EFs. Therefore, this study aimed to determine the effects of acute CE on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate.

Methods
Seventy-eight adults (mean age = 22.95, SD = 1.75 years) were randomly assigned to either a CE, AE, or control (CON) group. Participants in the CE group engaged in 12-min of AE (40–59% of heart rate reserve [HRR]) coupled with 13-min of RE (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). The AE group participated in 25 min of AE (40–59% HRR). Prior to and following exercise onset, participants in both the CE and AE groups completed a 5-min warm-up and cool-down. Participants in the CON group read books for 35 min. Lactate concentrations were measured at timepoints of 0-, 17-, and 30-min relative to the treatment onset. Response time (RT) and accuracy in the Stroop test, as well as P3 amplitude, were assessed before and after the treatment.

Results
The results revealed that both the CE and AE groups had significantly shorter RTs compared to the CON group, with no significant differences in accuracy among groups. A decrease in P3 amplitude was observed for the CE group compared to the AE and CON groups. The mediating effects of lactate between acute exercise and inhibitory control were insignificant.

Conclusions
The findings suggest that both CE and AE improve inhibitory control and CE potentially enhances the efficient allocation of attention resources. The lack of a significant mediating effect of lactate warrants further investigation.

Trial registration: ClinicalTrials.gov, NCT06370286. Registered 12 April 2024—Retrospectively registered, https://clinicaltrials.gov/study/NCT06370286.
Echocardiographic assessment of aortic regurgitation: a practical guideline from the British Society of Echocardiography
Authors: Victor Kelly , Ring Liam , Tsampasian Vasiliki , Oxborough David , Bhattacharyya Sanjeev , Hahn Rebecca T. 
Published: January 2025

Abstract
Aortic regurgitation is the third most common valve lesion with increasing prevalence secondary to an ageing population. Transthoracic echocardiography plays a vital role in the identification and assessment of aortic regurgitation and proves essential in monitoring severity and determining the timing of intervention. Building on the foundations of previous British Society of Echocardiography (BSE) recommendations, this BSE guideline presents an update on how to approach an echocardiographic assessment of aortic regurgitation. It provides a practical, step-by-step guide to facilitate a comprehensive, high-quality echocardiographic assessment of aortic regurgitation. It discusses commonly encountered echocardiography-based challenges with suggestions regarding how this information is relevant in the interpretation and grading of regurgitation severity. Additionally, the value of other cardiac imaging modalities is discussed. The guideline concludes with an overview of aortic regurgitation in the clinical context, addressing chronic versus acute aortic regurgitation, which features prompt referral for intervention, and the consequences of combined valve disease.
Mind–body treatments for children with functional gastrointestinal disorders
Authors: Stein Kate , Howarth Lucy , Zucker Nancy L. 
Published: January 2025

SUMMARY
Paediatric functional gastrointestinal disorders (P-FGIDs) are common, affecting up to 25% of children worldwide. They are characterised by chronic abdominal pain and/or altered bowel habits without an underlying disease pathology. P-FGIDs are often associated with co-occurring anxiety and depression across all ages and treating P-FGIDs may provide an opportunity to develop a young person's wider emotion regulation capacities. Using a fictitious case vignette, we outline the range of psychosocial and biomedical treatments for the disorder and the need for an integrated and holistic approach. We propose that by intervening early and enabling children to be curious about, rather than fearful of, their bodily sensations, clinicians may be able to alter harmful illness trajectories in both pain and psychiatric domains.
Assessing a clinical vital sign in severe mental illness: validation study of the 5 sit-to-stand test for monitoring muscle strength – The PsychiActive Project
Authors: Lopez-Moral Alvaro , Munguia-Izquierdo Diego , Bueno-Antequera Javier 
Published: January 2025

Background
In individuals with severe mental illness (SMI), low muscle strength heightens the risk of mortality and chronic disease development. Routine muscle strength assessments could identify vulnerabilities, thereby reducing the growing burden associated with SMI. However, integration into clinical settings faces obstacles because of limited resources and inadequate healthcare staff training. The 5 sit-to-stand (5-STS) test offers an alternative for measuring muscle strength compared with more complex or demanding tests. Nevertheless, its validity in individuals with SMI remains unexplored.

Aims
This study aimed to analyse the criterion validity of the 5-STS test in SMI, considering potential age, gender and body mass index influences.

Method
In a cross-sectional study following the ‘STrengthening the Reporting of OBservational studies in Epidemiology’ (STROBE) guidelines, 82 adults with SMI (aged 18–65, 24 women) were assessed. Participants underwent both the 5-STS test and the isometric knee extension strength (KES) test.

Results
Analysis revealed a significant moderate correlation coefficient and intraclass correlation coefficient (−0.58 for both) for all participants, indicating that the measures are valid and assess related aspects of the same construct. Strong agreement was observed in women and the older age groups. The 5-STS test demonstrated accuracy, with a standard error of estimate lower than the within-subject variability on the KES test. Bland–Altman plots showed limits of agreement values of −3.39 and 3.52 for the entire sample, and heteroscedasticity analyses indicated consistent differences between the 5-STS and KES tests across all groups analysed, except in the women's group.

Conclusions
The 5-STS test seems to be a valid test for assessing muscle strength in individuals with SMI, supporting its usefulness for routine assessment in clinical settings, facilitating detection and intervention in critical situations.
Bayesian inference of wall torques for active Brownian particles
Authors: Lambert Sascha , Duchêne Merle , Klumpp Stefan 
Published: January 2025

Abstract
The motility of living things and synthetic self-propelled objects is often described using Active Brownian particles. To capture the interaction of these particles with their often complex environment, this model can be augmented with empirical forces or torques, for example, to describe their alignment with an obstacle or wall after a collision.&#xD;Here, we assess the quality of these empirical models by comparing their output predictions with trajectories of rod-shaped active particles that scatter sterically at a flat wall. We employ a classical least-squares method to evaluate the instantaneous torque. In addition, we lay out a Bayesian inference procedure to construct the posterior distribution of plausible model parameters. In contrast to the least squares fit, the Bayesian approach does not require orientational data of the active particle and can readily be applied to experimental tracking data.
Mechanisms of Low Temperature-induced GH Resistance via TRPA1 Channel Activation in Male Nile Tilapia
Authors: Cao Zhikai , Wang Nan , Liu Xinrui , Deng Wenjun , Dong Rui , Jiang Quan 
Published: January 2025

Abstract
Low temperatures significantly impact growth in ectothermic vertebrates, though the underlying mechanisms remain poorly understood. This study investigates the role of transient receptor potential ankyrin 1 (TRPA1) channels in mediating low-temperature effects on growth performance and GH resistance in Nile tilapia (Oreochromis niloticus). Prolonged exposure to low temperature (16 °C for 35 days) impaired growth performance and induced GH resistance, characterized by elevated serum GH levels and decreased IGF-1 levels. Molecular analysis revealed tissue-specific upregulation of TRPA1 expression in the pituitary and liver under low-temperature conditions, concurrent with alterations in GH/IGF-1 axis-related gene expression. Pharmacological modulation of TRPA1 using an agonist mimicked low-temperature effects on the GH/IGF-1 axis, while an antagonist reversed cold-induced hormonal changes. In vitro experiments with tilapia hepatocytes demonstrated that TRPA1 activation decreased IGF-1 expression through calcium ion/calmodulin-dependent pathways and disrupted GH-induced JAK2/STAT5 signaling. Additionally, TRPA1 activation induced GH receptor degradation primarily through lysosomal pathways, with partial involvement of proteasomal mechanisms. This study is the first to reveal that TRPA1 channels play a crucial role in mediating the effects of low temperature on GH resistance in fish, providing new insights into temperature regulation of endocrine function. The evolutionary conservation of TRPA1 and the GH/IGF-1 axis suggests potential relevance to stress-induced endocrine dysfunction in other vertebrates, including mammals.
P-10 CUSHING'S SYNDROME WITH ATYPICAL ADRENAL MASS AND ELEVATED 17-HYDROXYPROGESTERONE: A DIAGNOSTIC CHALLENGE
Authors: Imre Eren , Salva Hazal , Ustay Ozlem , Yavuz Dilek Gogas 
Published: January 2025

Abstract

Introduction
Adrenal tumors can be challenging to diagnose, especially when they present with unusual biochemical profiles and unclear pathological findings. This case focuses on the management complexities of a patient with a heterogeneous adrenal mass, significantly elevated 17-hydroxyprogesterone levels, and Cushing's syndrome. The diagnostic uncertainty highlights the need for careful follow-up and further research into such adrenal tumors.

Clinical Case
A 63-year-old male with a 10-year history of hypertension presented with sudden severe back pain and dyspnea. He was diagnosed with a Type 3 aortic dissection, treated in the ICU, and later referred to endocrinology for secondary hypertension evaluation, where hypokalemia was noted.
Investigations revealed normal 24-hour urinary metanephrines (metanephrine: 142 µg, normetanephrine: 367 µg), and an aldosterone/renin ratio of 8 while on multiple antihypertensive medications. His BMI was 24.6. Endocrine evaluation showed a 1 mg dexamethasone suppression test result of 19.6 µg/dL, suppressed basal ACTH and DHEAS, midnight cortisol levels of 21 µg/dL and 27 µg/dL, and an increased 24-hour urinary free cortisol level of 1069 µg. The 17-hydroxyprogesterone levels were 26 ng/mL and 18 ng/mL.
A CT scan revealed a 47x40 mm heterogeneous lesion in the left adrenal gland. PET-CT and DOTATATE-PET scans showed mild to moderate FDG uptake, suggesting a possible, though unlikely, pheochromocytoma. The patient underwent a left adrenalectomy due to suspected Cushing's syndrome and potential adrenal malignancy. Pathology revealed a 6 cm lesion with no atypia, mitosis, or lymphovascular invasion, but the tumor was deemed neoplastic due to the disrupted excision capsule.
Postoperatively, the patient's Cushing's symptoms improved, and follow-up tests showed reduced cortisol and 17-hydroxyprogesterone levels. He was diagnosed with adrenal insufficiency and started on prednisolone therapy.

Conclusion
This case underscores the diagnostic challenges of adrenal tumors with atypical biochemical presentations. The significant postoperative reduction in 17-hydroxyprogesterone and resolution of Cushing's syndrome suggests functional activity of the adrenal mass. However, the indeterminate pathology raises concerns about malignancy and emphasizes the need for close long-term monitoring. The lack of definitive pathological criteria to distinguish benign from malignant adrenal tumors highlights a critical gap in current diagnostic methods, reinforcing the importance of integrating clinical, biochemical, and pathological data for management decisions.