bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study the air buoyancy force effect in an enhanced PVT solar collector with integrated porous medium
Authors: Bourouis Abderrahim , Boulhidja Sabar , Boukelia Taqiy Eddine , Omara Abdeslam 
Published: October 2023

Abstract
Hybrid photovoltaic thermal PVT solar collectors are a good option to produce electrical power and thermal energy simultaneously from solar radiation, where the transfer fluid circulating in this system works as a coolant, and at once, it gains additional heat to produce heat. This study is based on a numerical investigation, and aims to improve the performances of a hybrid photovoltaic thermal (PVT)collectorby using porous media, and taking into account the air buoyancy force effect (i.e., natural convection effect).For this purpose, the impacts of panel tilt angle (α), Richardson number (Ri), thickness of the porous layer (Ep) and Darcy number (Da) on the PVT system performances including its velocity contours, thermal field, thermal and electrical efficiencies are examined. The obtained results showed that by taking into account the buoyancy force, an enhancement in both electrical and thermal efficiencies is observed which can reach up 9.88% and 10% respectively if the PVT is erected without porous layer. Moreover, in the case of the buoyancy force is neglected, the integration of porous media under specific values of the studied parameters can enhance both electrical and thermal efficiencies by more than 26% and 38%, respectively compared to the classic layout of the PVT system.
Giant Sacrum Echinococcosis Secondary to Hepatic Echinococcosis: A Case Report
Authors: Chen Lei , Lv Jinhan , Fu Hui , Zhao Zihang , Zhang Yahui , Wang Zhen 
Published: October 2023

Abstract
Background and importance Echinococcosis is a common zoonotic disease found in the liver and lungs. Spinal echinococcosis is typically a secondary infection of other organs and is clinically rare, especially sacral echinococcosis. Methods Case report. Case summary A 52-year-old man presented with lower back pain and numbness in the left lower extremity. MRI showed a large mixed-signal shadow in the sacrum. The patient underwent an intervertebral foramenoscopic cyst decompression and flushing procedure and was subsequently administered albendazole for pain relief. After 5 years of postoperative follow-up, the patient had experienced repeated recurrence with a mean recurrence rate of 22 months and received surgical treatment at each symptomatic visit.
Conclusion This report presents the case of a patient with giant sacral echinococcosis that could not be completely removed due to the size of the cyst, providing clinical data for the diagnosis and treatment of sacrum echinococcosis secondary to hepatic echinococcosis.
Finite element modeling for analyzing the production of high-strength steel sheets for automobile parts
Authors: Sanrutsadakorn Apichat , Jhonthong Napatsakorn , Julsri Weerapong 
Published: October 2023

Abstract
An investigation was conducted on developing components from high-strength steel sheet grade 590, with a thickness of 2.40 millimeters using finite element analysis, with a focus on predicting springback and deviation behavior. This study centered on the manufacturing process of a Member C inner workpiece. The research comprised a comprehensive examination of chemical composition, microstructural analysis, and mechanical property testing to establish suitable material models for the forming process. The purpose of this study was to evaluate the accuracy of three separate material models, namely the Barlat89 yield criteria, the Y-U model, and the Barlat89 yield criteria + Y-U model. A cyclic tension-compression tests was used to determine the parameters of the Barlat89 yield criteria + Y-U model, which were then confirmed using the 1-element model. The manufactured samples predicted bend angles and the results of the experimental measurements were very consistent. Barlat89 yield criteria, Y-U model, and Barlat89 yield criteria + Y-U kinematic hardening model were used to predict the strain distribution springback and deviation behavior within the produced components. The results indicated that all three material models produced similar results concerning strain distribution. The material model based on Barlat89 yield criteria + Y-U model was determined to have the least inaccuracy when all seven sections were averaged, with angle θ1L equaling 93.66 degrees and angle θ1R equaling 93.13 degrees, underscoring its superior performance in predicting springback. The deviation behavior from the three material model simulations was very comparable. Consequently, it can be concluded that the Barlat89 yield criteria + Y-U model represented the most precise and suitable choice for simulating the formation of the Member C inner component.
The association between social activeness and frailty among the elderly in China - analysis based on 2018 CHARLS data
Authors: Li Qiugui , Cheng Hongtao , Cen Wenjiao , Yang Tao , Lyu Jun , Tao Shengru 
Published: October 2023

Abstract

Background
Frailty is a common health problem in older adults and is associated with several adverse health outcomes, including reduced physical function, cognitive decline, and reduced quality of life. Social activity is thought to be a key factor in preventing or slowing the progression of frailty. This study aimed to examine the relationship between social activity and frailty in older adults in China.
Methods
For the analysis, we used 2018 data from the China Health and Retirement Longitudinal Study (CHARLS), which included 7,862 older adults aged ≥ 60 years. Social activeness was statistically calculated based on relevant questions in the CHARLS questionnaire, with the aim of quantifying the frequency and quality of participants' social interactions and activities. Participants' level of frailty was measured using a specific frailty index scale designed to assess physical, cognitive, and psychological frailty in older adults. To analyze the relationship between social activity and frailty, we used logistic regression models to assess associations and calculated odds ratios (OR) and 95% confidence intervals (CI).
Results
A total of 7862 older adults (60 years or older) were recruited for this study, of whom 827 had frailty. The median age of the participants was 68 years (interquartile range: 64–74 years), 4429 (56.3%) were female. After adjustment for the mixed factor, social activity and frailty were significantly negatively associated in the elderly (adjusted OR: 1.68; 95% CI: 1.36–2.07; P < 0.001). Compared with high social activity (3 points or more), the risk of medium and low social activity (0 to 2 points) is higher (aOR: 1.64; 95% CI: 1.38–1.95; P < 0.001; E-value = 2.17).
Conclusions
Social activity is a protective factor against frailty and may reduce the risk of frailty in older adults. By improving the social activeness of the elderly, the risk of frailty can be reduced.
Clinical Characteristics and Prognostic Analysis of 24 Cases with Breast Diffuse Large B-cell Lymphoma
Authors: Yang Qiuhui , Fu Ye-qin , Xu Nin , Wang Jiaxuan , Yang Hong-jian , Zhang Xi-ping 
Published: October 2023

Abstract
Aim: We collected and analyzed the clinical characteristics and treatment methods of breast diffuse large B-cell lymphoma (B-DLBCL), and analyzed its prognosis to find the best treatment plan for B-DLBCL.
Methods: We collected clinical data of 24 patients with B-DLBCL treated at Zhejiang Cancer Hospital between July 2003 and November 2014, and performed prognostic analysis according to the patients' pathological types and treatments, as well as plotting the Progression-free survival (PFS) and overall survival (OS) curves.
Results: The included patients were all female (100%), with 92% (22/24) of patients presenting with breast masses, the majority (58%) presenting with left breast masses, and a very small portion presenting with bilateral breast masses; After a median follow-up of 51 (5-123) months, the PFS and OS of 24 patients were 72% and 80%, respectively; Among them, there were 14 cases of primary breast diffuse large B-cell lymphoma (PB-DLBCL), with corresponding PFS and OS of 85% and 83%, and their prognosis level is higher than that of secondary breast diffuse large B-cell lymphoma(SB-DLBCL); Among them, 13 patients underwent surgical treatment, and the prognosis of non-surgical patients was worse than that of surgical patients (PFS: 61% vs 80%; OS: 70% vs 87%); The 11 patients on rituximab had a non-significant improvement in PFS and OS compared with those not on rituximab (PFS: 72% vs 73%; OS: 79% vs 83%).
Conclusion: B-DLBCL is a group of heterogeneous diseases. In our retrospective study, we found that the prognosis of PB-DLBCL is better than that of SB-DLBCL. What’s more, surgical treatment can improve the prognosis, but the use of Rituximab has no effect on the prognosis.
On the ‘phylobaric’ classification of human respiratory viruses.
Authors: Çumaku Vaitson , Fortin Thomas , Hentz Sébastien , Masselon Christophe 
Published: October 2023

Abstract

Progress in genome sequencing technologies has transfigured biological research, including the field of virology. This had the unintended consequence of relegating structural phenotypic evaluations of viruses, and the associated methods, to mere complements of genomic approaches. Building on the work of Mazzone, and in light of recent advances in structural characterization techniques, we argue that individual virus molecular masses are distinctive characteristics that should be revisited. Based on available data, we estimated the theoretical masses of human respiratory viruses and observed that they distribute non-contiguously over a broad mass range. Our findings suggest that the total virion mass may constitute a meaningful attribute for a “phylobaric” (from ancient Greek ‘phûlon’ = lineage and ‘baros’ = weight) classification of human respiratory viruses. This observation could have fundamental implications in virology and relevance to public health.
Finding a needle in a haystack: DNA Haemoproteus columbae enrichment using percoll density gradient and flow cytometry
Authors: Gamboa-Suárez Brayan Andrés , Lotta-Arévalo Ingrid Astrid , Sarmiento-Salazar Felipe , Matta Nubia E. 
Published: October 2023

Abstract
Isolation of genomic DNA of blood parasites in birds, herpetofauna, and fishes is a challenging task, given that their red blood cells are nucleated; for that reason, parasite genomic DNA is only a fraction of the total extracted DNA, and it is challenging to obtain concentrated high-quality genetic material. Percoll Density Gradient (PDG) and flow cytometry are tools for separating and analyzing cell populations or even a single cell, and both represent potent approaches for isolating avian blood parasites. Our experimental design included several steps seeking to concentrate the parasite´s DNA. We used blood samples from a Rock pigeon infected with Haemoproteus columbae. After inducing parasite exflagellation in vitro, we subjected the samples to a Percoll Density Gradient to separate the parasites from the rest of the blood cells. Following centrifugation, the layer containing extracellular parasites underwent a flow cytometry and cell sorting process, during which we selected two different subpopulations of cells for analysis. Based on qPCR analyses, we demonstrate parasite DNA enrichment in Percoll Density Gradient and flow cytometry samples; simultaneously, these samples showed the lowest concentration of Columba livia DNA. However, the concentration of parasite DNA was higher in the PDG than in the cell sorting sample. This study reports the concentration of the Haemoproteus parasite by flow cytometry without DNA-intercalating dyes, and this methodology can serve as a technique for DNA enrichment of blood parasites that infect nucleated red blood cells to obtain complete genomes.
COVID-19 Vaccination and Mortality Reduction: A Prospective Cohort Study in Venezuela
Authors: Forero-Peña David A. , Leyva Jéssica L. , Valenzuela María V. , Omaña-Ávila Óscar D. , Mendoza-Millán Daniela L. , Sánchez-Ytriago Elisanny A. , Hachem Andrea C. Lahoud-El , Farro Katherine R. , Maita Ana K. , González Romina del C. , Rodriguez-Saavedra Carlis M. , Hernández-Medina Fernando , Camejo-Ávila Natasha A. , Nobrega Diana C. Freitas-De , Celis Rodrigo T. , Forero-Peña José L. , Martínez Alfonso , Grillet María E. , Landaeta María E. , Carrión-Nessi Fhabián S. 
Published: October 2023

Abstract
Background
While rigorous randomized clinical trials have substantiated the efficacy of COVID-19 vaccines in reducing hospitalization and mortality rates, there is a paucity of post-authorization analyses conducted in real-world settings. In Venezuela, the primary vaccines administered are Sinopharm and Sputnik-V. However, the performance and effectiveness of these vaccines within this specific population remain to be thoroughly investigated.
Methods
A prospective cohort study was undertaken from October 5, 2021, to March 31, 2022, across four sentinel hospitals in Venezuela. The outcomes were evaluated at two time points: day 28 and day 48, utilizing the WHO’s COVID-19 Clinical Progression Scale. For the purpose of analysis, patients were classified into two groups: vaccinated and unvaccinated.
Results
The study included a total of 175 patients, of which 85 (48.6%) were categorized as vaccinated, with the majority (76.5%) having received two doses. The median age of the patients was 68 years, with a slight predominance of females (53.1%), and the majority being unemployed/retired (60.6%). Hypertension (53.1%) and diabetes (18.3%) were the most prevalent comorbidities. The median Charlson index of the patients was 3 points, with no statistically significant differences observed between the groups (p = 0.2). Upon admission, dyspnea was more commonly observed in unvaccinated patients compared to vaccinated patients (76.7% vs. 62.4%, p = 0.039). Almost all laboratory parameters were comparable in both groups, with the exception of the median D-dimer level, which was significantly higher in unvaccinated patients (7.6 vs. 1.4 µg/mL, p = 0.015). A total of 50 patients (28.6%) died of the disease, with a higher proportion of deaths observed in unvaccinated patients compared to vaccinated patients (35.6% vs. 21.2%, p = 0.035). Factors such as advanced age (OR = 1.043, 95%CI = 1.015–1.071, p = 0.002) were associated with increased odds of death, while factors such as vaccination against COVID-19 (OR = 0.428, 95%CI = 0.185–0.99, p = 0.047), high oxygen saturation (OR = 0.964, 95%CI = 0.934–0.995, p = 0.024), and enoxaparin administration (OR = 0.292, 95%CI = 0.093–0.917, p = 0.035) were associated with decreased odds of death.
Conclusion
In the course of the third and fourth waves of the pandemic, vaccination against COVID-19 was found to be associated with a 57% reduction in mortality among patients treated in four public hospitals in Venezuela.
Causal associations between plasma ADAMTS-5 protein level and cancer risk: a bi-directional mendelian randomization analysis
Authors: Huang Rongzhi , Lu Tanli , Qin Jihao , Fang Xiaowen , Liang Chenxi , Li Siyu , Li Jiehua 
Published: October 2023

Abstract

Background
According to relevant research, ADAMTS-5 was associated with some cancers. However, the causal relationship between ADAMTS-5 and different types of cancers is still unclear.
Methods
The genome-wide summary statistics of plasma ADAMTS-5 protein level and 17 differential types of cancers were acquired for the deCODE database, the IEU Open GWAS project and FinnGen database. The estimated causal effect was given by the Wald ratio for each variant, the inverse-variance weighted model was used for two or more genetic instruments. Sensitivity analyses were conducted to assess the robustness of MR results. The Bonferroni corrected significance was set at P < 0.0015 (0.05/34) to account for multiple testing, and a lenient threshold P < 0.05 was considered to suggestively relationship. To strengthen our findings in MR analysis, we conducted the Bayesian co-localization analysis for validation analyses apart from using an independent cohort.
Results
After Bonferroni correction, we only detected significant evidence for genetic prediction of the causal relationship between ADAMTS-5 and oropharyngeal cancer (OR: 0.62, 95%CI: 0.47–0.81, P = 0.0007). ADAMTS-5 had suggestive associations with esophagus cancer (OR: 0.73, 95%CI: 0.55–0.98, P = 0.034). There had no statistical effect on other cancers. There was also no evidence of the reverse causal relationships. Our findings also were found in independent cohort. Furthermore, we detected the presence of a shared variant for the association between ADAMTS-5 and oropharyngeal cancer by Bayesian co-localization analysis (PP4 > 0.8), strengthening our results.
Conclusions
MR analysis reveal that plasma ADAMTS-5 level had significantly causal association with oropharyngeal cancer. It also existed suggestive associations with esophagus cancer. ADAMTS-5 was a potential drug target for oropharyngeal cancer, thus providing guidance for further clinical research.
A comparison between the adverse event profiles of patients receiving palbociclib and abemaciclib: analysis of the two real-world databases
Authors: Takeda Tatsuaki , Sugimoto Shiho , Matsumoto Jun , Iwata Naohiro , Nakamoto Akihiko , Ozaki Aya Fukuma , Hamano Hirofumi , Ariyoshi Noritaka , Zamami Yoshito 
Published: October 2023

Abstract
Background: Palbociclib and abemaciclib are cyclin-dependent kinase (CDK) 4/6 inhibitors currently used to treat breast cancer. Although their therapeutic efficacies are considered comparable, differences of adverse event (AE) profiles between the two drugs remain unclear.
Aim: We analysed two real-world databases, the World Health Organization’s VigiBase and the Food and Drug Administration Adverse Event Reporting System (FAERS), to identify the differences in AE profiles between palbociclib and abemaciclib.
Method: Data of patients with breast cancer receiving palbociclib or abemaciclib recorded until December 2022 were extracted from the VigiBase and FAERS databases. In total, 200 types of AEs were analysed. The reporting odds ratios were calculated using a disproportionality analysis.
Results: Cytopenia was frequently reported in patients receiving palbociclib, while interstitial lung disease and diarrhoea were frequently reported in those receiving abemaciclib. Moreover, psychiatric and nervous system disorders were more common in the palbociclib group, whereas renal and urinary disorders were more common in the abemaciclib group.
Conclusion: This study was the first to show comprehensive disparities in the AE profiles between palbociclib and abemaciclib and highlighted the importance of considering these when selecting a suitable CDK4/6 inhibitor to ensure safe and favourable outcomes for patients with breast cancer.
Impact of in vitro treatment of Pyrazinamide (PZA), AgNO3 and salinity on the Expression of ACS3, ACO1, EIN2 and EIL1 genes in Tomato (Lycopersicon esculentumL.) plants
Authors: Zarei Somayeh , Ehsanpour Ali Akbar , Javadirad Seyed Morteza 
Published: October 2023

Abstract
Salinity stress is a major environmental factor that negatively impacts plant growth and agricultural productivity. Ethylene, a crucial plant hormone, plays a vital role in regulating various physiological processes in response to environmental stresses, including salinity stress. In this study, we investigated the effect of two ethylene inhibitors, PZA and AgNO3, on the expression of key ethylene synthesis and signaling genes in tomato plants (Lycopersicon esculentum L.) under salinity stress in in vitro conditions. Tomato seedlings were subjected to salinity stress by supplementing the growth medium with NaCl, and different concentrations of PZA and AgNO3 were applied. The expression patterns of ACS3, ACO1, EIN2, and EIL1 genes, involved in ethylene biosynthesis and signaling, were analyzed using real-time quantitative PCR (qPCR). Under salinity stress, the expression of ACS3 and ACO1 genes was upregulated, indicating increased ethylene production. However, the application of PZA and AgNO3 treatments effectively suppressed ACS3 and ACO1 gene expression by 23% and 14%, respectively. Similarly, the ethylene signaling genes, EIN2 and EIL1, exhibited increased expression under salinity stress, but their expression was significantly reduced by 60–88% with PZA and AgNO3 treatments. The study shows that PZA and AgNO3 inhibitors effectively improve stress tolerance in tomato plants under salinity stress. These inhibitors offer insights into ethylene-mediated responses and potential strategies for developing stress-resilient crop varieties. Further research is needed to explore interactions between inhibitors and the ethylene signaling pathway and validate their practical application in agriculture.
External Validation of a Red Cell-based Blood Prognostic Score in Patients With Metastatic Renal Cell Carcinoma Treated With First- Line Immunotherapy Combinations
Authors: MAFFEZZOLI Michele , SANTONI Matteo , MAZZASCHI Giulia , RODELLA Sara , LAI Eleonora , MARUZZO Marco , BASSO Umberto , BIMBATTI Davide , IACOVELLI Roberto , ANGHELONE Annunziato , FIALA Ondřej , REBUZZI Sara Elena , FORNARINI Giuseppe , LOLLI Cristian , MASSARI Francesco , ROSELLINI Matteo , MOLLICA Veronica , NASSO Cecilia , ACUNZO Alessandro , SILINI Enrico Maria , QUAINI Federico , DE FILIPPO Massimo , BRUNELLI Matteo , BANNA Giuseppe L. , RESCIGNO Pasquale , SIGNORI Alessio , BUTI Sebastiano 
Published: October 2023

Abstract
Introduction
Immunotherapy combinations with tyrosine-kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) had significantly improved outcomes of patients with mRCC. Predictive and prognostic factors are crucial to improve patients' counseling and management. The present study aimed to externally validate the prognostic value of a previously developed red cell-based score, including hemoglobin (Hb), mean corpuscular volume (MCV) and red cell distribution width (RDW), in patients with mRCC treated with first-line immunotherapy combinations (TKI plus ICI or ICI plus ICI).
Materials and methods
We performed a sub-analysis of a multicentre retrospective observational study (ARON-1 project) involving patients with mRCC treated with first-line immunotherapy combinations. Uni- and multivariable Cox regression models were used to assess the correlation between the red cell-based score and progression-free survival (PFS), and overall survival (OS). Logistic regression were used to estimate the correlation between the score and the objective response rate (ORR).
Results.
The prognostic impact of the red cell-based score on PFS and OS was confirmed in the whole population regardless of the immunotherapy combination used [median PFS (mPFS): 17.4 vs 8.2 months, HR 0.66, 95% CI 0.47–0.94; median OS (mOS): 42.0 vs 17.3 months, HR 0.60, 95%CI 0.39–0.92; p < 0.001 for both].
Conclusion.
We validated the prognostic significance of the red cell-based score in patients with mRCC treated with first-line immunotherapy combinations. The score is easy to use in daily clinical practice and it might improve patient counselling.