bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applicability and robustness of an artificial intelligence-based assessment for Greulich and Pyle bone age in a German cohort
Authors: Pape Johanna , Hirsch Franz Wolfgang , Deffaa Oliver Johannes , DiFranco Matthew D. , Rosolowski Maciej , Gräfe Daniel 
Published: December 2023

Purpose The determination of bone age (BA) based on the hand and wrist, using the 70-year-old Greulich and Pyle (G&P) atlas, remains a widely employed practice in various institutions today. However, a more recent approach utilizing artificial intelligence (AI) enables automated BA estimation based on the G&P atlas. Nevertheless, AI-based methods encounter limitations when dealing with images that deviate from the standard hand and wrist projections. Generally, the extent to which BA, as determined by the G&P atlas, corresponds to the chronological age (CA) of a contemporary German population remains a subject of continued discourse. This study aims to address two main objectives. Firstly, it seeks to investigate whether the G&P atlas, as applied by the AI software, is still relevant for healthy children in Germany today. Secondly, the study aims to assess the performance of the AI software in handling non-strict posterior-anterior (p. a.) projections of the hand and wrist.
Materials and Methods The AI software retrospectively estimated the BA in children who had undergone radiographs of a single hand using posterior-anterior and oblique planes. The primary purpose was to rule out any osseous injuries. The prediction error of BA in relation to CA was calculated for each plane and between the two planes.
Results A total of 1253 patients (aged 3 to 16 years, median age 10.8 years, 55.7 % male) were included in the study. The average error of BA in posterior-anterior projections compared to CA was 3.0 (± 13.7) months for boys and 1.7 (± 13.7) months for girls. Interestingly, the deviation from CA tended to be even slightly lower in oblique projections than in posterior-anterior projections. The mean error in the posterior-anterior projection plane was 2.5 (± 13.7) months, while in the oblique plane it was 1.8 (± 13.9) months (p = 0.01).
Conclusion The AI software for BA generally corresponds to the age of the contemporary German population under study, although there is a noticeable prediction error, particularly in younger children. Notably, the software demonstrates robust performance in oblique projections.
Key Points
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Working Memory, Attention Skills, and Language Proficiency in Children with Unilateral and Bilateral Cochlear Implants
Authors: Dikderi Cagla , Ozkan Atak Hilal B. , Yucel Esra 
Published: December 2023

Abstract
Background Previous studies observed that children with cochlear implants (CIs) have poor language, working memory, and attention skills. The ability to perform cognitive tasks, such as attention and memory, plays a crucial role in the academic achievement and everyday life of children with hearing impairment.
Purpose This study aimed to evaluate and compare the effects of age at the time of implantation and bilateral hearing on cognitive skills, such as language development, working memory, and selective attention, among children with CIs.
Research Design Language skills were assessed using the Test of Language Development-Primary: Fourth Edition (TOLD-P:4), working memory using the Visual-Aural Digit Span Test-Revised Form (VADS-R), and selective attention skills using the Stroop Test TBAG Form.
Study Sample A total of 58 participants, comprised of 21 children with early unilateral CIs (before 2 years), 18 children with late unilateral CIs (after 2 years), and 19 children with bilateral CIs, between the ages of 6 and 9 years, were included in the study.
Data Collection and Analysis According to the age at the time of implantation and whether or not the participant was unilaterally or bilaterally implanted, the mean scores, percentage values, and resultant scores of the participants were calculated using the Mann–Whitney U test. The number of repeated backward digit spans for the VADS-R test, completion times, number of errors and corrections for the Stroop test, raw scores, scaled scores corresponding to raw scores at the relevant age, descriptive terms for the TOLD-P:4 test, and within-group comparisons for all tests were examined.
Results There were significant differences in language, working memory, and attention skills between individuals with early and late unilateral cochlear implantation, whereas there were no significant differences in many subtests between individuals with early unilateral and bilateral cochlear implantation.
Conclusion These findings demonstrate the importance of early cochlear implantation and bilateral hearing on the development of cognitive processes, such as language development, selective attention, and memory skills, which are important factors that may contribute to children's academic performance and overall success.
Evaluation of a Patient Decision Aid for Refractive Eye Surgery
Authors: Subbaraman Bhavani , Ahmed Kamran , Heller Matthew , Essary Alison C. , Patel Vimla L. , Wang Dongwen 
Published: December 2023

Abstract
Background We developed a prototype patient decision aid, EyeChoose, to assist college-aged students in selecting a refractive surgery. EyeChoose can educate patients on refractive errors and surgeries, generate evidence-based recommendations based on a user's medical history and personal preferences, and refer patients to local refractive surgeons.
Objectives We conducted an evaluative study on EyeChoose to assess the alignment of surgical modality recommendations with a user's medical history and personal preferences, and to examine the tool's usefulness and usability.
Methods We designed a mixed methods study on EyeChoose through simulations of test cases to provide a quantitative measure of the customized recommendations, an online survey to evaluate the usefulness and usability, and a focus group interview to obtain an in-depth understanding of user experience and feedback.
Results We used stratified random sampling to generate 245 test cases. Simulated execution indicated EyeChoose's recommendations aligned with the reference standard in 243 (99%). A survey of 55 participants with 16 questions on usefulness, usability, and general impression showed that 14 questions recorded more than 80% positive responses. A follow-up focus group with 10 participants confirmed EyeChoose's useful features of patient education, decision assistance, surgeon referral, as well as good usability with multimedia resources, visual comparison among the surgical modalities, and the overall aesthetically pleasing design. Potential areas for improvement included offering nuances in soliciting user preferences, providing additional details on pricing, effectiveness, and reversibility of surgeries, expanding the function of surgeon referral, and fixing specific usability issues.
Conclusion The initial evaluation of EyeChoose suggests that it could provide effective patient education, generate appropriate recommendations, connect to local refractive surgeons, and demonstrate good system usability in a test environment. Future research is required to enhance the system functions, fully implement and evaluate the tool in naturalistic settings, and examine the findings' generalizability to other populations.
Cross-cultural Adaptation and Psychometric Evaluation of the Kurdish Version of the Disabilities of Arm, Shoulder, and Hand (DASH-KU) Scale
Authors: Hasan Rebwar A. , Barawi Omer A. , Hasan Jalal A. 
Published: December 2023

Abstract
Background The disabilities of arm, shoulder, and hand (DASH) questionnaire addresses the patient's disabilities and symptoms to evaluate the extent and the impact of injuries in the patient's daily-life activities. This study aims to develop a valid and reliable adaptation of DASH into the Kurdish language and culture (DASH-KU).
Methods American Association of Orthopedic Surgeons Outcomes Committee guideline was used for the cross-cultural adaptation of DASH to the Kurdish version. This study was conducted at the Shahid Saifaddin consultation clinic in Sulaymaniyah, Iraq between April and October 2022. A total of 300 participants, who were included in the study using an available sampling method, completed the self-report DASH-KU questionnaire during two consecutive assessments with a 24-hour interval.
Results The DASH-KU questionnaire demonstrated excellent internal consistency (Cronbach's α = 0.99) and test–retest reliability (intraclass correlation = 0.99). A strong correlation between DASH-KU scores and the patient-rated wrist/hand evaluation tool (r = 0.792) supported its construct validity. Bland–Altman plots showed good agreement between assessments with no floor (3%) or ceiling (0%) effects. Factor analysis found the scale had high adequacy (0.700) and significant sphericity (p < 0.001). The major factor explained 40% of variance with an eigenvalue of 13.14. Additionally, a five-item model explained 81.23% of DASH-KU variance, though responsiveness was suboptimal, possibly due to the short 24-hour interval between measurements.
Conclusion Our results demonstrate that DASH-KU has excellent reliability and validity in identifying upper limb injuries, and the psychometric properties of DASH-KU were similar to its original version.
Screening for Mutations in Hereditary Cancer Susceptibility Genes in a Region with High Endogamy in Brazil
Authors: Oliveira Polyanna , Correa Paula , Acosta Angelina , Freitas Juliana , Machado-Lopes Taísa , Bomfim-Palma Thais , Ribeiro-dos-Santos Ândrea , Santos Sidney , Nascimento Roberto , Nascimento Ivana , Abe-Sandes Kiyoko 
Published: December 2023

Abstract
Introduction Cancer is a multifactorial disease dependent on the influence of genetic and environmental factors. About 10% of cancers are associated with germline mutations, which predispose to a higher risk of developing cancer. Currently, the use of panels that identify susceptibility and/or association genes cancer has been increasingly used, both in clinical practice and in scientific research.
Objective To investigate genetic mutations in patients with a profile for hereditary cancer in individuals from a region of northeast Brazil, where there is a high frequency of endogenous and consanguineous marriages.
Methods A set of 17 genes (BRCA1, BRCA2, APC, TP53, PTEN, RET, VHL, RB1, CDKN2, CDH1, CHEK2, MLH1, MSH2, MSH6, MUTYH, XPA, and XPC) associated with cancer and hereditary syndromes were analyzed. Fifteen patients with a hereditary cancer profile were evaluated.
Results The pathogenic variant found was c.1187G > A (p.Gly396Asp), rs36053993 in the MUTYH gene in a male patient diagnosed with melanoma at the age of 43 years and a family history for this tumor. This gene encodes an important enzyme related to DNA repair and has been associated with other types of cancer, this is the first report of an association with melanoma, the biological plausibility of this association is given once the MUTYH protein is expressed in the skin tissue and is responsible for repairing damage caused, for example, by sun exposure.
Conclusion The results of this study suggest that this mutation may be important for the hereditary predisposition to melanoma, but a broader investigation of this mutation is needed.
Impact of digital city competitiveness on total factor productivity in the commercial circulation industry: evidence from China’s emerging first-tier cities
Authors: Meng Tiantian , Yu Danni , Ye Ludi , Yahya M. H. , Zariyawati M. A. 
Published: December 2023

AbstractIn the age of rapid technological advancement, the proliferation of digital technologies has reshaped urban landscapes, affecting economic, social, and environmental dynamics. Urban digital transformation is more than just a technological innovation; it stands at the core of future urban competitive strategies. As this trend evolves, the commercial circulation industry is poised for significant opportunities. However, the academic exploration into the relationship between the level of urban digitalization and the total factor productivity of the commercial circulation industry remains limited. To address this gap, this study employs data from 15 emerging first-tier cities in China. Initially, a Digital City Competitiveness Index was established, with results indicating Hangzhou taking the lead, while other cities were categorized into distinct tiers. Utilizing a two-way fixed-effects model, the research then investigates the impact of digital city competitiveness on the total factor productivity of the commercial circulation industry. The findings suggest that digital city competitiveness significantly enhances the total factor productivity within this industry. Furthermore, the study examines the influences of various sub-dimensions of digital city competitiveness on total factor productivity. Notably, investments in urban information infrastructure emerge as the most pronounced positive factor, followed by industrial development, innovation, services, and governance. In contrast, the urban ecosystem dimension exerts a negative impact. This research fills an existing void in the literature concerning the relationship between digital city competitiveness and total factor productivity, offering profound insights into the interplay between digital city development and its economic benefits. In addition, the conclusions provide policy implications for decision-makers, highlighting the importance of bolstering urban information infrastructure, encouraging enterprises to innovate, fostering industrial clusters, enhancing urban service capabilities through digital means, elevating public participation, and emphasizing environmental conservation.
The born-digital in future digital scholarly editing and publishing
Authors: O’Sullivan James , Pidd Michael 
Published: December 2023

AbstractEditorial scholarship is once again in a state of upheaval. Digital scholarly editing, for all it has achieved, has not accommodated the increasingly digital nature of cultural production and consumption. The theories and practices of digital scholarly editing need to better account for born-digital cultural materials like social media content, digital fiction, and video games. This paper discusses the state-of-the-art in digital scholarly editing, and advocates for future forms of digital scholarly editing and publishing suited to the born-digital.
The structural relations of self-control, empathy, interpersonal trust, friendship quality, and mental well-being among adolescents: a cross-national comparative study in China and Canada
Authors: Niu Jinpeng , Jin Chao , Meng Lingqi 
Published: December 2023

AbstractThe aim of the present study was to explore the structural relationships between self-control, empathy, interpersonal trust, friendship quality, and mental well-being among Chinese (N = 3595) and Canadian (N = 2056) adolescents. A structural equation modeling (SEM) approach was adopted by means of a multi-group analysis. Within the aggregate sample, empathy and interpersonal trust were shown to be related to mental well-being both directly and indirectly, with friendship quality as the mediating variable, whereas self-control merely had a direct effect on mental well-being. The multiple-group analysis revealed a series of discrepancies, showing that empathy had a significant impact on the mental well-being of Chinese but not Canadian adolescents. Furthermore, empathy exerted a significantly stronger effect on friendship quality for Chinese than for Canadian adolescents, whereas interpersonal trust had a significantly stronger impact on friendship quality among Canadian than among Chinese adolescents. The differences were discussed from a cross-cultural perspective concerning collectivism versus individualism. The measures employed in the present study are closely related to social and emotional skills; the findings therefore may point to benefits for both Chinese and Canadian adolescents in terms of enhancement of their cultural-specific social and emotional skills as well as their well-being.
Next generation of multispecific antibody engineering
Authors: Keri Daniel , Walker Matt , Singh Isha , Nishikawa Kyle , Garces Fernando 
Published: December 2023

Abstract
Multispecific antibodies recognize two or more epitopes located on the same or distinct targets. This added capability through protein design allows these man-made molecules to address unmet medical needs that are no longer possible with single targeting such as with monoclonal antibodies or cytokines alone. However, the approach to the development of these multispecific molecules has been met with numerous road bumps, which suggests that a new workflow for multispecific molecules is required. The investigation of the molecular basis that mediates the successful assembly of the building blocks into non-native quaternary structures will lead to the writing of a playbook for multispecifics. This is a must do if we are to design workflows that we can control and in turn predict success. Here, we reflect on the current state-of-the-art of therapeutic biologics and look at the building blocks, in terms of proteins, and tools that can be used to build the foundations of such a next-generation workflow.
Program for advancing supervisor skills among pharmacy technicians
Authors: MacKinnon Taylor , Schaeffler Kristen , Kent Stan , Clark John S 
Published: December 2023

Abstract

Purpose
This publication outlines the development and implementation of a leadership enhancement program for pharmacy technician supervisors at University of Michigan Health (UMH). The program aims to equip these supervisors with the skills and knowledge necessary to excel as leaders in the pharmacy field, addressing the pressing need for strong leaders in healthcare.

Summary
UMH recognized the need to cultivate effective leaders within its pharmacy department due to the impending shortage of pharmacy leaders and the rising demand for technicians and future pharmacists. To meet this need, a leadership enhancement program was introduced, offering flexibility and a comprehensive framework for enhancing the skills of pharmacy technician supervisors. The program covers annual, biennial, and flexible rotating topics and offers a structured monthly format for active participation. Additionally, the program utilizes a rigorous selection process for training resources and continuous quality improvement efforts to ensure effectiveness. Through developing leadership skills among technician supervisors, the organization aims to achieve tangible benefits, including decreased turnover rates and increased employee satisfaction.

Conclusion
The program for enhancing supervisor skills at UMH is a flexible and adaptable framework for leadership development in pharmacy. Its success in enhancing leadership skills for future pharmacy leaders is crucial in the evolving healthcare landscape and supports the growth of leaders in this domain. By acknowledging the value and expertise that pharmacy technicians bring, organizations can harness their potential and, in turn, benefit the entire healthcare system. This program’s principles are transferable to other organizations seeking to empower their employees with tools to thrive in new leadership roles, thus contributing to their growth and success.
An updated job-exposure matrix for occupational noise: development and validation
Authors: Sjöström Mattias , Lewné Marie , Alderling Magnus , Selander Jenny , Gustavsson Per 
Published: December 2023

Abstract

Objectives
The aim of this study was to create a quantitative job-exposure matrix (JEM) for noise including a large set of measurements for the Swedish workforce, a detailed exposure-level assessment, spanning over an extensive time period from 1970 to 2014.

Methods
The JEM was developed by 2 teams, each with an experienced occupational hygienist and an occupational safety engineer. Each pair assessed the exposure using measurements performed and reported by occupational hygienists, occupational safety engineers, or similar, from 1970 to 2014. The measurements included either the original LAeq(8h) measurements or an LAeq(8h) levels calculated from partial measurements of the working day, provided that the measurement targeted a regular task usually performed during a full workday. The collection of measurement reports was done in 2008 and 2012 by contacting clinics working in the area of occupational health or occupational safety engineers and their submitted reports were added to our own material. Noise exposure assessments were inserted at the appropriate time period for the relevant job family. The final matrix was developed in a consensus procedure and the validity was investigated by comparison of the 2 team’s individual results.

Results
The noise JEM contains 321 job families with information regarding occupational noise from 1970 to 2014. The time-period label has a 5-yr scale starting in 1970. The estimated average 8 h (TWA) noise level in decibels [dB(A)] for every job family and 5-yr period was coded as 1: &lt;70 dB(A), 2: 70 to 74 dB(A), 3: 75 to 79 dB(A), 4: 80 to 84 dB(A) or 5: 85(+) dB(A). The validation showed no systematic difference in relative position and very high agreement in the ordering of paired ordinal classifications. The JEM has also successfully been applied in several epidemiological studies.

Conclusions
We present a JEM for occupational noise using Swedish data from 1970 to 2014 with a higher degree of sensitivity in assessed noise exposure compared with the previously existing version. Repeated application of the JEM, in epidemiological studies, has shown consistent results and contributed to yielding important findings.
Mechanisms of grapevine resilience to a vascular disease: investigating stem radial growth, xylem development and physiological acclimation
Authors: Dell’Acqua Ninon , Gambetta Gregory A , Delzon Sylvain , Ferrer Nathalie , Lamarque Laurent J , Saurin Nicolas , Theodore Pauline , Delmas Chloé E L 
Published: December 2023

Abstract

Background and Aims
Plant vascular diseases significantly impact crop yield worldwide. Esca is a vascular disease of grapevine found globally in vineyards which causes a loss of hydraulic conductance due to the occlusion of xylem vessels by tyloses. However, the integrated response of plant radial growth and physiology in maintaining xylem integrity in grapevine expressing esca symptoms remains poorly understood.

Methods
We investigated the interplay between variation in stem diameter, xylem anatomy, plant physiological response and hydraulic traits in two widespread esca-susceptible cultivars, ‘Sauvignon blanc’ and ‘Cabernet Sauvignon’. We used an original experimental design using naturally infected mature vines which were uprooted and transplanted into pots allowing for their study in a mini-lysimeter glasshouse phenotyping platform.

Key Results
Esca significantly altered the timing and sequence of stem growth periods in both cultivars, particularly the shrinkage phase following radial expansion. Symptomatic plants had a significantly higher density of occluded vessels and lower leaf and whole-plant gas exchange. Esca-symptomatic vines showed compensation mechanisms, producing numerous small functional xylem vessels later in development suggesting a maintenance of stem vascular cambium activity. Stabilization or late recovery of whole-plant stomatal conductance coincided with new healthy shoots at the top of the plant after esca symptoms plateaued.

Conclusions
Modified cropping practices, such as avoiding late-season topping, may enhance resilience in esca-symptomatic plants. These results highlight that integrating dendrometers, xylem anatomy and gas exchange provides insights into vascular pathogenesis and its effects on plant physiology.