bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embolization of arteriovenous malformations of head and neck: A systematic review
Authors: Malik Muhammad Hammad , Jabal Mohamed Sobhi , Kobeissi Hassan , Gupta Rishabh , Bilgin Cem , Brinjikji Waleed 
Published: December 2023

Background Cervicofacial arteriovenous malformations (AVMs) are a significant source of morbidity. Endovascular embolization has emerged as a promising treatment technique for these lesions. However, current literature on cervicofacial AVM embolization mostly consists of single-agent oriented case series, and to date, no comprehensive study has compared the outcomes of available embolic agents. Purpose To investigate the performance of different embolic agents in the management of cervicofacial AVMs. Methods We systematically searched Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials Scopus, and Web of Science. Studies providing data for the endovascular treatment of cervicofacial AVMs were included. The data regarding complication and cure rates were collected for each embolic agent. Pooled event rates were presented as descriptive statistics. Results Eleven studies comprising 204 patients were included in the review. The overall complete and partial cure rates were 62.2% (127/204) and 36.2% (74/204), respectively. Embolization failed to achieve significant improvement in only 1.6% (3/204) of the patients. The complete cure rates were 87.5% (75–100%) for n-Butyl cyanoacrylate (NBCA, glue), 80.5% (61–100%) for Onyx (Medtronic, MN, USA), and 51.5% (18–85%) for ethanol. The overall complication rate was 30% (61/204). The complication rates were 33% (12.5–53%) for ethanol, 14% (0–28%) for Onyx, and 0% for NBCA. Conclusions Our systematic review supports that endovascular embolization is an effective treatment option for cervicofacial AVMs. In our review, the use of Onyx and NBCA was associated with consistently high complete cure rates and a promising safety profile. However, more research is needed to investigate the use of different embolic agents in the treatment of cervicofacial AVMs.
Multicenter study of the safety and effectiveness of intracranial aneurysm treatment with the p64MW-HPC flow modulation device
Authors: Ernst M , Jamous A , Bartl M , Riedel CH , Holtmannspötter M , Voit-Höhne H , Grieb D , Schlunz-Hendann M , Fiebig T , Fiorella D , Klisch J , Lobsien D 
Published: December 2023

Background and purpose The new p64 flow diverter with hydrophilic polymer coating (HPC) was designed to reduce thrombogenicity. To date, it is unclear how antithrombogenic surface modifications affect neoendothelialization and thrombus formation in patients with unruptured intracranial aneurysms. The purpose of this study was to evaluate the safety and effectiveness of the p64MW-HPC in the treatment of unruptured aneurysms of small to giant size and of both the anterior and posterior circulation. Materials and methods Between March 2020 and October 2022 all patients with unruptured intracranial aneurysms treated with the p64MW-HPC were included at five neurovascular centers. Demographic data, aneurysm characteristics, antiplatelet therapy, procedural complications, and clinical and angiographic outcomes were recorded. Results A total of 100 patients with 100 unruptured intracranial aneurysms met the inclusion criteria. Eighty-three aneurysms were classified as saccular, 12 aneurysms were fusiform, 4 aneurysms dissecting, and 1 aneurysm was blister-like. Dual antiplatelet therapy with Clopidogrel and Aspirin was given in 68 cases, and with Ticagrelor and Aspirin in 24 cases. Technical issues with deployment were encountered in 14 cases (torsion ( n = 3), foreshortening ( n = 8), and incomplete opening ( n = 3)). Ischemic stroke occurred in a total of seven cases. In one patient a wire perforation and subsequent severe ICH occurred. Complete aneurysm occlusion at angiographic follow-up (mean time = 7 months) was seen in 73% and adequate occlusion in 93%. Conclusion This study is the largest multicenter study to date documenting the safety and effectiveness of the new antithrombogenic p64MW-HPC in the treatment of unruptured intracranial aneurysms of the anterior and posterior circulation.
Associations between depression and anxiety index and frequency of acute exacerbation in chronic obstructive pulmonary disease
Authors: Hong Yu Jin , Kim Youlim , Moon Ji-Yong , Park Shinhee , Lee Jung-Kyu , Jung Ki-Suck , Yoo Kwang Ha , Kim Yu-Il , Choi Joon Young 
Published: December 2023

Background: Comorbidities of chronic obstructive pulmonary disease (COPD) influence clinical characteristics and prognosis. Objectives: This study compared the clinical characteristics and exacerbation rate of COPD according to the presence of depression or anxiety. Design: This study used data from The Korea COPD Subgroup Study (KOCOSS) cohort, a nationwide prospective cohort from 54 medical centers, between April 2012 and 2019. Methods: Depression and anxiety were diagnosed with the Beck Depression Inventory and Beck Anxiety Inventory. Negative binomial regression analysis was performed to analyze the frequency of exacerbations in depressed patients and anxiety. Differences in lung function trajectory according to presence of depression/anxiety were analyzed using a linear mixed model. Results: In all, 2147 patients were enrolled. Depressed patients or anxiety had lower lung function, higher modified Medical Research Council (mMRC) grade, St. George Respiratory Questionnaire (SGRQ) score, and COPD assessment test score, and higher rates of exacerbation in the past year than those without depression/anxiety. Depressed patients had a higher frequency of moderate to severe exacerbations [Incidence Rate Ratio (IRR): 1.57, CI: 1.17–2.11, p = 0.002] and those with anxiety had higher frequencies of moderate to severe (IRR: 1.52, CI: 1.03–2.27, p = 0.038) and severe exacerbations (IRR: 2.13, CI: 1.09–4.15, p = 0.025) during 1-year follow-up compared to those without these comorbidities. The differences in the change in annual forced expiratory volume in 1 seconds (FEV1) over 3 years according to the presence of depression or anxiety were not statistically significant. Conclusion: Depressed and anxious patients showed increased respiratory symptoms and exacerbation rate as well as reduced health-related quality of life, whereas there were no significant differences in changes in lung function between groups with and without depression/anxiety.
Age-related differences in Russian and Hungarian linguistic pictures of the world
Authors: Lenart Istvan , Markovina Irina , Endrody Orsolya 
Published: December 2023

This cross-cultural, interdisciplinary study aims to investigate how the linguistic picture of the world differs in various age groups from kindergarten years to adulthood. In this paper, linguistic picture of the world is referred to as a technical term introduced into linguistics by Leo Weisgerber (Weltbild der Sprache). In order to trace the differences in Russian and Hungarian language users’ linguistic picture of the world in different age groups, thus obtaining a more precise picture of the linguistic development of the individual from a cross-cultural perspective, a research was conducted and data were collected with the aid of the association experiment, a foundational research method of Russian psycholinguistics. Respondents from three age groups (4–5 years, 10–12 years, and 18–26 years) were investigated via the collection of word associations to 10 stimulus words. As the research results suggest, culturally bound traits of linguistic development were identified, including the Russian linguistic consciousness changing its orientation from being self- and family-oriented in early childhood to being people-oriented (man-oriented) as an adult. The study also revealed common characteristics of the age-related development of the Russian and Hungarian linguistic pictures of the world, for instance, toys and games moving from the center of the linguistic image of the world to the periphery to be replaced by love. Results can be utilized not only for theoretical psycholinguistic purposes including a better description of the presumed age-related changes in the mental lexicon but also in the practical realm of education for curriculum development or the fine-tuning of pedagogical methods, as well as in intercultural studies for gaining a more precise picture of the linguistic consciousness of representatives of different cultures.
The Efficacy of Sodium Phytate as a Natural Chelating Agent in Reducing Elevated Calcium Levels in Nasal Mucus Among Individuals Experiencing Olfactory Dysfunction Following COVID-19: A Prospective Randomized Double-Controlled Clinical Trial
Authors: Altemani Abdullah H. , Alanazi Mansuor A , Altemani Assem H. , Alharbi Adnan , Alsahali Saud , Alotaib Nawaf M. , Abdelazim Mohamed H. 
Published: December 2023

Background COVID-19 has been associated with olfactory disturbances in many infected patients. The increase in calcium levels in nasal secretions plays an essential role in the olfactory process with a desensitizing effect on olfactory receptor neurons and negative effects on odor transmission. Calcium chelating agents have the ability to bind calcium in nasal mucus and prevent the negative effects associated with calcium increase. Objectives The aim of this work is to demonstrate the intra-nasal topical application of sodium phytate, an environmentally friendly, non-harmful calcium chelating agent, to reduce the adverse effects of calcium on olfactory function and improve olfactory dysfunction according to COVID-19. Methods Fifty-two patients with a previous COVID-19 and olfactory dysfunction lasting longer than 90 days were enrolled in a prospective, randomized, blinded, controlled clinical trial. Patients were divided into two equal groups: 26 patients received nasal spray containing 0.9% sodium chloride and 26 patients received nasal spray containing 1% sodium phytate. Olfactory function was measured before treatment and 1 month later using the Sniffin’ Sticks test. Calcium content of nasal secretions was determined before and after treatment with an ion-selective electrode. Results A significant improvement from anosmia to hyposmia was demonstrated after the use of sodium phytate compared with no improvement after the use of sodium chloride. In addition, a decrease in the level of calcium in nasal secretions was observed after the use of sodium phytate. Conclusion Sodium phytate has benefit role on improving the olfactory function after COVID-19.
Lessons learned on data collection for a digital health intervention—insights and challenges from Nigeria
Authors: Umoh Edidiong , Isiguzo Chimaobi , Akwaowo Christie , Attai Kingsley , Ekpenyong Nnette , Sabi Humphrey , Dan Emem , Obinna Nwokoro , Uzoka Faith-Michael 
Published: December 2023

Objectives: This article delves into the challenges of medical data collection during the COVID-19 pandemic in developing countries, using Nigeria as a case study. It emphasizes how data collection impacts research quality, reliability, and validity. Methods: Qualitative research utilizing purposive sampling was employed to explore experiences in designing a diagnostic tool for febrile diseases in Nigeria. A questionnaire with selectable and open-ended questions was utilized for data collection, and 23 respondents participated. Results: Among 74 potential participants, 23 valid responses were gathered, revealing significant themes related to experiences and challenges in medical data collection. A multidisciplinary team approach proved beneficial, fostering collaboration, enhancing knowledge, and promoting positive experiences. Despite challenges with paper questionnaires, most participants preferred them for ease of use. Connectivity issues hindered timely data uploading and disrupted virtual meetings. Conclusion: Innovative and flexible strategies, such as a blended data collection approach and well-coordinated teams, were vital in overcoming challenges. Electronic data collection tools, reminders, and effective communication played key roles, leading to positive outcomes. This study provides valuable insights for researchers and practitioners involved in data collection, particularly in developing countries like Nigeria.
Modified endoluminal ureteral stenting for the management of proximal ureteral obstruction in two cats
Authors: Khoo Teng-Xiang , Wang Shaojing , Chambers Brenton , McMillan Angus , Yates Guy 
Published: December 2023

Case series summary Two cases of placement of modified endoluminal ureteral stents are described, for revision of a subcutaneous ureteral bypass (SUB) and for primary treatment of obstructive ureterolithiasis. Modified endoluminal stents were inserted through the ureterotomy, anchored in the renal pelvis with a single pigtail and shortened to a length sufficient to span the proximal ureter and ureterotomy site. Relevance and novel information The advantages of this approach as a surgical option for feline obstructive ureterolithiasis are demonstrated, including the avoidance of disruption, or bypass, of the ureterovesicular junction, minimisation of implanted foreign material and avoidance of intravesicular stent mass, maintenance of the physiological route of urine flow, including preservation of active distal ureteral function, and limitation of the potential complications of ureterotomy. The clinical efficacy of this adaptation of the previously published endoluminal stenting technique is demonstrated with its applicability de novo and in the revision of other stenting procedures.
A Helping Hand Isn’t Always So Helpful: Parental Autonomy Support Moderates the Effectiveness of Interpersonal Emotion Regulation for Emerging Adults
Authors: Newman Madeline , Davis Elizabeth L. 
Published: December 2023

The current study examined parental autonomy support in relation to the quality of youths’ interpersonal emotion regulation (IER) experiences with parents. 194 emerging adult college students ( M age = 19.6 years; 52.1% women) recounted a recent instance of receiving IER from a parent. Youth reported on their parent’s IER behaviors (emotional responsiveness and cognitive support), the perceived effectiveness of the IER, who initiated it, and how autonomy supportive their parent typically was. As expected, parental autonomy support moderated the relation between IER and its perceived effectiveness, such that at higher levels of support, parental emotional responsiveness and cognitive support related to higher perceived IER effectiveness. Likewise, in conditions of low autonomy support, youth perceived unsolicited IER to be less effective than did youth who sought the support. Autonomy support likely plays a meaningful role in the effectiveness of various IER processes, thus furthering our understanding of emerging adults’ socioemotional development.
Importance of Incorporating the Perspectives of People with Cancer into Oncology Education: A Scoping Review
Authors: Dutt Hanna , Dean Arleigh , Kamal Rayyan Syed , Allan Alison L. 
Published: December 2023

Background With the shift towards person-centered care (PCC) in oncology, there is a need for parallel evolution of oncology education programs to prepare the next generation of health professionals to deliver effective PCC. These programs should be designed utilizing perspectives from individuals who have lived experience with cancer to ensure that changes to education curricula translate to improved PCC in the clinic. Objectives Our goal was to identify existing literature describing such programs as well as identify gaps for further development. Methods Keywords were agreed upon and searched across Ovid Medline, Ovid Embase, ERIC, Google Scholar, and MedEdPORTAL databases. Duplicates were removed, unique articles were screened for relevance by title and abstract, and a full text review of each article was completed for validation. Included articles describe methods for involving people with cancer in developing and/or delivering oncology-focused education programs. Results In total, 15 articles describing 12 unique oncology education programs from 7 different countries were identified, reviewed, and summarized. These programs involved learners undertaking undergraduate medical education, postgraduate medical education, continuing medical education, or training as nurses or radiation therapists. Current literature indicates that classroom-based sessions, experiential or simulated learning modalities, and/or asynchronous online modules can all feasibly be created with the integration of perspectives/narratives of people with cancer. Furthermore, involving people with cancer directly in the design and/or delivery of these education programs may contribute to improved patient experiences. Conclusions Including the perspectives of people with cancer directly in oncology curriculum development and delivery can improve established pedagogical approaches and enhance learner confidence and competency in delivering PCC. We provide recommendations for stepwise implementation of patient perspectives into oncology education, with the hope that future programs will better prepare and motivate learners to provide PCC aimed at improving cancer care, quality of life, and disease outcomes.
Effect of Yttrium doping on antibacterial and antioxidant property of LaTiO3
Authors: Prabitha V. G. , Sahadevan Jhelai , Madhavan Maya , Muthu S. Esakki , Kim Ikhyun , Sudheer T. K. , Sivaprakash P. 
Published: December 2023

AbstractThe advancement of multidrug-resistant bacterial strains and their adverse effects is one of the most significant global health issues. The perovskite nanomaterial with combined antioxidant and antibacterial activities in one molecule has the potential for improved therapeutic solutions. In this work, Yttrium-doped Lanthanum Titanate (LaTi1 −xYxO3, where x = 0, 0.05, and 0.1) was synthesized using auto combustion technique. Excellent crystalline structure with a tetragonal system is revealed by X-ray diffraction analysis (XRD). UV–Visible diffuse reflectance spectroscopy (UV–Vis DRS), Fourier transform infrared (FTIR), and photoluminescence (PL) were used to study its optical characteristics. The field emission scanning electron microscope (FE-SEM) shows rod-like pellet-shaped Yttrium-doped nanostructures, and the elements present were confirmed with the Energy Dispersive X-Ray Analysis (EDAX). Various concentrations of the synthesized materials were tested for antibacterial activity against Gram-positive (Staphylococcus aureus 902) and Gram-negative (E. coli 443) strains using the agar-well diffusion method with gentamicin antibiotic as a positive control. High antibacterial activity of 87.1% and 83.3% was shown by 10% Yttrium-doped LaTiO3 (LY(0.1)TO) at 500 mg/mL against both positive and negative stains, respectively. Moreover, the antioxidant properties of synthesized materials were assessed with IC50 values of 352.33 µg/mL, 458.055 µg/mL, and 440.163 µg/mL for samples LaTi1 − xYxO3, where x = 0, 0.05, and 0.1 respectively. The antibacterial and antioxidant capabilities of the proposed samples illustrate their applicability in various biomedical applications.
PEPMatch: a tool to identify short peptide sequence matches in large sets of proteins
Authors: Marrama Daniel , Chronister William D. , Westernberg Luise , Vita Randi , Koşaloğlu-Yalçın Zeynep , Sette Alessandro , Nielsen Morten , Greenbaum Jason A. , Peters Bjoern 
Published: December 2023

Abstract
Background
Numerous tools exist for biological sequence comparisons and search. One case of particular interest for immunologists is finding matches for linear peptide T cell epitopes, typically between 8 and 15 residues in length, in a large set of protein sequences. Both to find exact matches or matches that account for residue substitutions. The utility of such tools is critical in applications ranging from identifying conservation across viral epitopes, identifying putative epitope targets for allergens, and finding matches for cancer-associated neoepitopes to examine the role of tolerance in tumor recognition.

Results
We defined a set of benchmarks that reflect the different practical applications of short peptide sequence matching. We evaluated a suite of existing methods for speed and recall and developed a new tool, PEPMatch. The tool uses a deterministic k-mer mapping algorithm that preprocesses proteomes before searching, achieving a 50-fold increase in speed over methods such as the Basic Local Alignment Search Tool (BLAST) without compromising recall. PEPMatch’s code and benchmark datasets are publicly available.

Conclusions
PEPMatch offers significant speed and recall advantages for peptide sequence matching. While it is of immediate utility for immunologists, the developed benchmarking framework also provides a standard against which future tools can be evaluated for improvements. The tool is available at https://nextgen-tools.iedb.org, and the source code can be found at https://github.com/IEDB/PEPMatch.
Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study
Authors: Zeng Chuan , Zhang Chaolong , He Chunming , Song Haimin 
Published: December 2023

Abstract
Background
Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to uncover the causal relationship between glioblastoma and the gut microbiome using Mendelian randomization analysis.

Methods
We conducted a bidirectional Mendelian randomization study using summary statistics of gut microbiota derived from the MiBioGen consortium, the largest database of gut microbiota. Summary statistics for glioblastoma were obtained from IEU OpenGWAS project, which included 91 cases and 218,701 controls. We assessed the presence of heterogeneity and horizontal pleiotropy in the analyzed data. We primarily employed the inverse variance weighting method to investigate the causal relationship between gut microbiota and glioblastoma after excluding cases of horizontal pleiotropy. Four other analysis methods were employed as supplementary. Excluding abnormal results based on leave-one-out sensitivity analysis. Finally, reverse Mendelian randomization analysis was performed.

Results
Four genus-level taxa and one family-level taxa exhibited causal associations with glioblastoma. And these results of reverse Mendelian randomization analysis shown glioblastoma exhibited causal associations with three genus-level taxa and one family-level taxa. However, the Prevotella7(Forward, P=0.006, OR=0.34, 95%CI:0.158-0.732; Reverse, P=0.004, OR=0.972, 95%CI:0.953-0.991) shown the causal associations with glioblastoma in the bidirectional Mendelian randomization.

Conclusions
In this bidirectional Mendelian randomization study, we identified five gut microbiota species with causal associations to glioblastoma. However, additional randomized controlled trials are required to clarify the impact of gut microbiota on glioblastoma and to reveal its precise mechanisms.