bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intramural Administration of Translational Inhibitor Puromycin Upon Balloon Angioplasty Inhibits SMC Proliferation and Protein Synthesis–Vascular Proteome Profiling Analysis
Authors: Boettger Priyanaka , Schwertz Hansjörg , Platsch Herbert , Mueller‐Werdan Ursula , Werdan Karl , Buerke Michael 
Published: February 2025

ABSTRACTIntroductionPercutaneous transluminal coronary angioplasty (PTCA) is an effective procedure to decrease the severity of stenotic coronary atherosclerotic lesions. However, its long‐term success is limited by the formation of restenosis or neointima by increased proliferation of smooth muscle cells (SMCs) and synthesis of extracellular matrix. Polypeptide growth factors are potent SMC mitogens and are involved in SMC proliferation and extracellular matrix (ECM) synthesis. In this line, inhibition of de novo protein synthesis might be beneficial.MethodsWe examined the effects of different concentrations of translational inhibitor puromycin on SMC proliferation and apoptosis, in vitro. Further, we examined the effects of local administration of puromycin in a rabbit balloon injury model of the iliac artery.ResultsInjection of puromycin or its vehicle was performed with an infusion‐balloon catheter directly into the vessel wall during angioplasty. PTA in the vehicle group resulted in neointima formation 3 weeks after the vascular intervention. In contrast, puromycin treatment resulted in a significant reduction of intima–media ratio. We observed decreased elastin and collagen III synthesis in puromycin‐treated animals. With proteomics, we could demonstrate reduced protein expression of lamin, vimentin, alpha‐1 antitrypsin, alpha‐actin allowing puromycin treatment. In in vitro experiments, puromycin decreased SMCs proliferation (i.e., BrdU incorporation) following FCS stimulation.PerspectiveBased on the data from our animal experiments, aministration of puromycin directly into the vessel wall during angioplasty may be effective in preventing or reducing restenosis in humans.
Proteome of Renal Tubuli and Serum Differentiate Pre‐Existing Type 2 Diabetes and Post‐Transplant Diabetes in Kidney Transplant Recipients
Authors: Skandalou Eleni , Rivedal Mariell , Marti Hans‐Peter , Halden Thea A. S. , Jenssen Trond , Vikse Bjørn Egil , Åsberg Anders , Furriol Jessica 
Published: February 2025

ABSTRACTPurposeDiabetes mellitus (DM) is a major cause of end‐stage kidney disease (ESKD), with kidney transplantation being the preferred treatment. However, post‐transplant diabetes mellitus (PTDM) increases mortality and graft loss. While PTDM and Type 2 diabetes mellitus (T2DM) share risk factors, their mechanisms differ, particularly in diabetic nephropathy (DN). This study aimed to investigate the molecular differences in PTDM by mapping the proteomes of proximal tubuli and serum in normoglycemic (NG), pre‐transplant T2DM, and PTDM patients one year post‐transplantation. Experimental Design Proteomic analysis was performed on microdissected proximal tubular cells and serum samples from kidney transplant recipients categorized as NG, pre‐transplant T2DM, or PTDM at one year post‐transplantation. Mass spectrometry was used to identify differentially expressed proteins. Data analyses were performed using gene ontology databases and pathway analysis.ResultsProteomic analysis revealed key differences, including significant dysregulation of mitochondrial proteins and lipid metabolism pathways in PTDM patients compared to T2DM and NG groups. Additionally, we observed distinct serum patterns of cholesterol metabolism dysregulation in PTDM, highlighting a complex interplay between fatty acid metabolism, mitochondrial dysfunction and systemic lipid dysregulation that may drive renal injury in PTDM‐related DN.Conclusions and Clinical RelevanceThis pilot study is the first to perform proteomic analysis on both microdissected tubular cells and serum from post‐transplant PTDM, pre‐transplant T2DM and NG transplant recipients. The proteomic differences between PTDM and T2DM could help to develop targeted therapies and early diagnostic markers, ultimately improving transplant outcomes and patient management. Further research is needed to validate these findings and explore their therapeutic potential.
In Situ Grown Oxygen‐Vacancy Rich NiCo‐LDHs for High‐Performance Supercapacitors
Authors: Liu Wang , Qiu Kaige , Su Yuanhui , Li Shengfen , Ma Mengyue , Wu Tongzhen , Huan Yu , Shen Xuesong , Wei Tao 
Published: February 2025

AbstractLayered double hydroxides (LDHs) are increasingly recognized as highly promising electrode materials for supercapacitors, owing to their exceptional specific capacitance, notable redox activity, and superior anion exchange capability. However, several challenges still need to be addressed to achieve the theoretical specific capacitance and excellent rate capacity, including poor electronic and ionic conductivity. In this study, a two‐step method was employed to prepare high electronic and ionic conducting NiCo‐LDH‐Vo materials, demonstrating enhanced electrochemical performance as supercapacitor electrodes. First, NiCo‐LDH was directly electrodeposited onto high‐conductivity nickel foam, which enhanced the electronic conductivity and avoided the effects of adhesives. Second, soak NiCo‐LDH in H2O2 solution to introduce more oxygen vacancies. The resulting NiCo‐LDH‐Vo exhibited higher electron conductivity and ion diffusion ability, leading to increased specific capacity and long‐term stability (771.8 C g−1 at 1 A g−1 with an excellent capacity retention rate of 92%).
Constructing CoWO4/Cd0.5Zn0.5S Heterojunction for Enhanced Visible Light Driven Photocatalytic Degradation of Organic Pollutants
Authors: Liu Yujun , Lan Meng , Dong Xiaoli , Zheng Nan , Gou Jialin 
Published: February 2025

AbstractThe ecosystems and human health have been gravely impacted by growing organic pollutants and photocatalysis and is regarded as one of the most valid and green governance approaches. Herein, a novel type II CoWO4/Cd0.5Zn0.5S (CWO/CZS) heterojunction photocatalyst was constructed by a secondary hydrothermal method and applied to the photodegradation of rhodamine B (RhB) and methyl orange (MO). The experimental results show that the CWO/CZS heterojunction photocatalyst exhibits excellent photodegradation activity toward RhB and MO under visible light irradiation. CWO/CZS (0.10:1) achieved a degradation efficiency of 96.7% for RhB within 15 min and the apparent rate constants were 135 and 5 times of CWO and CZS, respectively. The high photodegradation rate of MO also demonstrates its excellent photocatalytic activity. The significant improvement in the photocatalytic degradation rate originated from the expansion of visible light absorption and dense interfacial contact between the nanoparticles, which could effectively accelerate the transfer of photogenerated charges. This work demonstrates a novel type II heterojunction photocatalyst for the effective removal of organic dyes, providing fresh ideas for wastewater purification.
Comparison of Ethynylation Mechanisms of Ketones with Acetylenes in the Presence of Organic t‐Bu‐P4/DMSO and Inorganic KOH/DMSO Superbases: A Detailed Quantum Chemistry Study
Authors: Orel Vladimir B. , Teplyashin Nikita V. , Manzhueva Anastasia A. , Bobkov Alexander S. 
Published: February 2025

AbstractWe report the first detailed investigation of the mechanism of ethynylation reaction of acetone with phenylacetylene in the presence of organic superbase phosphazene t‐Bu‐P4 performed using the combined quantum chemistry approach MP2/6–311+G**//B3LYP/6–31+G*. It is shown that the mild experimental conditions of the reaction (r.t., 2 h) relate to the low activation barrier of the limiting stage (∆G‡ = 19.7 kcal/mol). A comparative analysis of the reaction mechanisms in the presence of t‐Bu‐P4/DMSO and KOH/DMSO revealed some distinctive features of the action of these superbases. The “soft” t‐Bu‐P4H+ cation only slightly stabilizes the pre‐reaction complex and the alcoholate ion, slightly destabilizing the transition state. The reaction in the presence of t‐Bu‐P4/DMSO can be considered to proceed as with the free phenylethynide ion, which suggests the possibility of regeneration of t‐Bu‐P4 and its use in catalytic quantities. In contrast, the “hard” potassium cation exerts strong stabilization of both the pre‐reaction complex and the transition state, leading to a decrease in the activation barrier. Our results revealed a very strong stabilization of the alcoholate ion by the potassium cation (∆∆G = −13.0 kcal/mol), which would inhibit regeneration of the KOH base, suggesting it should be used in stoichiometric quantities.
Efficient Enrichment of Rubidium and Cesium from High‐Salt Solution by Copper Hexacyanoferrate Co‐Precipitation
Authors: Li Chenxi , Li Kang , Li Shina , Ma Ruixin 
Published: February 2025

AbstractCesium (Cs) and rubidium (Rb) are important rare alkali metal elements that are scarce and dispersed in nature. They often coexist with high amounts of Na+ and K+. In this study, copper hexacyanoferrate (CuHCF) was used as a co‐precipitant to enrich Cs+ and Rb+ in a high‐salt solution. The effect of parameters, such as type and dose of divalent metal ions, solution pH, material dropping speed, reaction time, and temperature, was investigated for the recovery rate of Cs+ and Rb+. Results showed that the recovery rates of Cs+ and Rb+ were 99.78% and 88.84% at the optimal Cu2+/(Cs++Rb+) molar ratio of 0.5, respectively. The reaction could be completed within 10 min in pH 3–8. The detailed characterization of the Cs+ and Rb+ containing co‐precipitants, CsRb–CuHCF, confirm a general formula of Cs1.09Rb0.81K0.16Cu0.97Fe(CN)6. The (Cs++Rb+)/(Na++K+) increased significantly from 0.074 to 28.47 before and after precipitation, which realized the effective enrichment of Cs+ and Rb+. Studies of the precipitation reaction mechanism showed that the precipitant reacted first with Cs+ and then with Rb+. This process offers a promising avenue for the enrichment and separation of Cs+ and Rb+ from high‐salty solutions.
Targeting IL‐23 with Small Molecule Inhibitors: A New Horizon In Psoriasis Therapy
Authors: Sharbaji Raghad , Siyah Pinar 
Published: February 2025

AbstractInterleukin‐23 (IL‐23) is a dominant cytokine in psoriasis, a chronic inflammatory skin disease that severely diminishes patients' quality of life and reduces lifespan by up to 10 years. Despite therapeutic advancements, psoriasis remains a clinical challenge due to the absence of a definitive cure, treatment side effects, and substantial economic burden. Notably, no small molecule inhibitors (SMIs) directly targeting IL‐23 have been developed to date, leaving a critical gap in current therapies. In this study, SMIs emerged as promising therapeutic alternatives. A high‐throughput virtual screening of 1.57 million molecules was conducted, followed by molecular docking and molecular dynamics (MD) simulations (1, 10, and 100 ns) to identify potential candidates. Machine learning‐based binary QSAR models and MetaCore analysis established the relevance of these hits to psoriasis and other skin diseases. As a result, tenapanor (MM/GBSA score: −101.66 kcal/mol) and ChemBridge ID 7740 and ID 360118 (−101.59 kcal/mol, −91.003 kcal/mol) emerged as top candidates, demonstrating exceptional binding affinity and stability in 100‐ns simulations. These inhibitors represent promising therapeutic leads, offering an alternative to existing biologics. Further in vitro and in vivo validation will be essential to confirm their efficacy and potential as the first IL‐23‐targeted small molecule therapies.
Telework During and After COVID‐19: The Role of FSSB and Boundary Management in Teleworkers' Well‐Being
Authors: Carvalho Vânia Sofia , Estreder Yolanda , Chambel Maria José , Castanheira Filipa 
Published: February 2025

ABSTRACTTelework gained popularity during the COVID‐19 pandemic. However, for this flexible work arrangement to be a favourable option nowadays, specific conditions may be necessary such as supervisory support (FSSB) and boundary management strategies. Nonetheless, telework conditions during COVID‐19 may have differed from those after the pandemic. Drawing on border theory and the conservation of resources theory, FSSB is framed in this paper as an important contextual resource for teleworkers' well‐being. Furthermore, boundary management strategies (i.e., boundary control and enacted work‐family segmentation) are explored as linking mechanisms between FSSB and teleworkers' well‐being. Study 1, with a cross‐sectional design, captured telework during COVID‐19, and Study 2, with a daily design, captured telework after COVID‐19 with the moderating role of frequency of daily changes in the workplace, that is, telework and in‐house work. Consistent findings were observed across both studies indicating not only the critical role of FSSB for teleworkers' well‐being (i.e., burnout and work engagement) but also the boundary management strategies as mediators. Moreover, Study 2 reveals that the fewer the changes in the workplace, the more FSSB are needed.
Tuning Self‐Assembly of Hole‐Selective Monolayers for Reproducible Perovskite/Silicon Tandem Solar Cells
Authors: Er‐Raji Oussama , Lange Stefan , Hartwig Carl Eric , Prasetio Adi , Bivour Martin , Hermle Martin , Turek Marko , De Wolf Stefaan , Glunz Stefan W. , Borchert Juliane , Schulze Patricia S. C. 
Published: February 2025

AbstractSelf‐assemble monolayers (SAMs) have become state‐of‐the‐art hole‐selective contacts for high‐efficiency perovskite‐based solar cells due to their easy processing, passivation capability, and low parasitic absorption. Nevertheless, for the deposition of SAMs with a monolayer thickness and a high packing density on metal oxide substrates, critical challenges persist. To overcome these, the study focuses on the impact of annealing temperature – an intrinsic yet so far unexplored process parameter – during the formation of SAMs. By performing in situ angle‐resolved X‐ray photoelectron spectroscopy combined with advanced data analysis routines, it is revealed that increasing the annealing temperature reduces the formed SAM layer thickness from a multilayer stack of ≈5 nm at 100 °C (conventional temperature employed in literature) to a monolayer at 150 °C. Furthermore, denser adsorption of the SAM to the metal oxide surface is promoted at high temperatures, which enhances the interfacial SAM/perovskite passivation quality. With this strategy, a 1.3%abs power conversion efficiency (PCE) increment is obtained in fully‐textured perovskite/silicon tandem solar cells, with improved reproducibility, and a champion device approaching 30% PCE. This study advances the understanding of SAMs formation and presents a promising strategy for further progress in high‐efficiency perovskite‐based solar cells.
Finite element modeling and experimental investigation of reinforced geopolymer concrete T‐beam externally strengthened in flexure with side‐bonded glass fiber‐reinforced polymer laminates
Authors: Das Ajaya Kumar , Dwibedy Saswat , Biswal Uma Shankar 
Published: February 2025

AbstractThe current investigation focuses on developing a finite element (FE) model using ansys parametric design language (APDL) for fiber‐reinforced geopolymer concrete (GPC). In this study, fly ash and ground granulated blast furnace slag based GPC were used, and glass fiber‐reinforced polymer (GFRP) was considered for strengthening the T‐beam. To overcome the issue of providing fiber‐reinforced polymer on the soffit of existing beams, the study was done on the effect of GFRP on the flexural strength of the side‐bonded flexure‐deficient T‐beam. GFRP was provided in three layers through the application of epoxy. All the specimens were tested under a two‐point load to determine flexural strength. The FE model was validated through the experimental results we obtained in the laboratory. The validated models were used for further parametric studies of T‐beams with varying compressive strength, steel reinforcement ratio, and GFRP laminate size. The findings illustrated that finite element modeling is effective in predicting the structural response of T‐beams constructed with GPC, ensuring accurate results.
Poland’s EU Narrative: Between Nativist and Internationalist Visions of Europe
Authors: Styczyńska Natasza 
Published: February 2025

Abstract
‘Europe’ has always occupied an important place in Polish public and political discourse. The country’s location at the crossroads between eastern and western Europe has left a firm imprint on the identities of Poles and their way of understanding Europe. This chapter examines how, two decades after the so-called ‘big bang’ enlargement, Poland’s membership of the EU and the EU is narrated. The first part of the chapter discusses the Polish understanding of Europe, which is often mythologised and politicised. The second part presents the official national EU narrative analyses, comparing the pre- and post-accession periods. A third and final section considers the narration of the EU in times of crisis, as well as recent developments regarding the rule of law, LGBTQ community rights in Poland and the COVID-19 pandemic. The chapter discusses two distinct narratives about Poland’s relationship with ‘Europe’—one nativist, the other internationalist.
Indoor UWB Localization Algorithm for Multi-robot and Its Application
Authors: Wang Shuo , Xu Zhihao , Liu Kaiwen , Liao Yuanjiang , Li Xiaorong , Zhong Yule 
Published: February 2025

Abstract
Multi-robot are difficult to accurately locate in complex indoor space environments, with high real-time requirements and the inability to utilize satellite signals, thus limiting their application range. This article studies relevant algorithms based on the demand for indoor localization solutions in open intelligent manufacturing factories, existing UWB localization methods and principles. By measuring the distance value between the tag and the base station, and then using these distance values to calculate the tag coordinates, localization function can be achieved. Designed a localization scheme, built an indoor multi-robot UWB localization system, achieved precise positioning, and successfully verified the effectiveness of its algorithm. By combining multi-robot motion control technology with UWB positioning, it can be applied to indoor logistics transportation, achieve automatic data collection, and reduce costs and increase efficiency.
Antiretroviral drug exposure in pregnancy and risk of congenital anomalies: a European case/non-case malformed study
Authors: Saint-Lary Laura , Beau Anna-Belle , Sommet Agnès , Leroy Valériane , Loane Maria , Cavero-Carbonell Clara , Garne Ester , Hoareau Jonathan , Bielenska Anna Latos , Monier Isabelle , Nelen Vera , Neville Amanda J. , O’Mahony Mary , Perthus Isabelle , Pierini Anna , Rissmann Anke , Rouget Florence , Sichitiu Joanna , Tucker David , Dolk Helen , Damase-Michel Christine 
Published: February 2025

Abstract

Purpose
Antiretroviral drugs are recommended during pregnancy to achieve HIV viral suppression and reduce mother-to-child transmission. Congenital anomaly signals were reported after fetal exposure to antiretroviral drugs in several studies warranting further investigation. We aimed to evaluate the risk of congenital anomalies after fetal exposure to antiretroviral drugs using the European congenital anomaly registry data.

Methods
A case/non-case study was performed, using the EUROmediCAT central database. All the congenital anomalies, exposed to any antiretroviral drugs, were included from 1995 to 2019. We explored each signal identified from the literature for associations between congenital anomalies and specific antiretroviral exposures. We compared antiretroviral exposure between the signal anomalies (cases) and all other malformed registrations (controls). Reporting odds ratio (ROR) and their 95% confidence intervals were estimated and adjusted for registry and maternal age.

Results
Between 1995 and 2019, 173 cases of congenital anomalies were observed after any exposure to antiretroviral drugs. The signal previously identified in the literature between congenital heart defects and exposure to zidovudine was confirmed in the main analysis (aROR 3.66 [1.63–8.23]). Other signals identified in the literature were not confirmed, although two cases of hypospadias and two cases of limb defects were reported after zidovudine and atazanavir exposure, respectively. The signal detection analysis did not reveal any new signal after applying the Bonferroni correction.

Conclusions
Our study does not reveal new signals but confirms the previously identified signal between congenital heart defects and fetal exposure to zidovudine. The physio-pathological hypothesis induced by zidovudine exposure should be explored in future studies.
Cochlear implantation with Slim Modiolar Electrode carriers enables hearing preservation
Authors: Sakmen Kenan Dennis , Issing Christian , Vazzana Caterina , Weißgerber Tobias , Linke Albrecht , Stöver Timo , Helbig Silke 
Published: February 2025

Abstract

Purpose
To investigate hearing preservation in patients who received a cochlear implant with a preformed electrode carrier, namely the Slim Modiolar (SM).

Methods
A monocentric, retrospective study was conducted. A total of 51 adult patients (24 females, 27 males), representing 60 ears, were included in the final evaluation.
The mean age was 60.9 ± 15.2 years (range 17.5–89.7 years). All patients had some degree of residual hearing. Frequency-specific pure-tone audiometry was performed at three time points: preoperatively (T0), within 30 days postoperatively (T1), and at a later time point during follow-up (T2; 20.7 ± 17.6 months). Low frequency pure tone average and the HEARRING group formula were used to facilitate comparison of hearing preservation rates with other results published so far.

Results
In the first month after surgery, no significant deterioration was observed for the low frequencies, but a significant deterioration was observed at follow-up. Using the HEARRING classification system, the average short-term (T0–T1) hearing preservation score was 70%, which corresponds to partial hearing preservation. During follow-up (T0–T2), the score decreased to 61% in the study group, still representing partial hearing preservation. Complete hearing loss occurred in 20% of the cases.

Conclusion
Especially in the low frequency range, the utilisation of SM electrode carriers during cochlear implantation facilitates preservation of residual hearing.
Ethical Correlates of Family Control: Socioemotional Wealth, Environmental Performance, and Financial Returns
Authors: Gómez-Mejía Luis R. , Muñoz-Bullón Fernando , Requejo Ignacio , Sanchez-Bueno Maria J. 
Published: February 2025

Abstract
We examine and test the environmental performance of family firms across 22 European countries and find that they exhibit better environmental performance than nonfamily firms. This result confirms prior research conducted in the United States. More specifically, we conclude that family firms engage in more substantive environmental actions than nonfamily firms. Furthermore, we hypothesize and confirm that family firms do not pay a financial price for lower emissions, which should facilitate the voluntary, non-instrumental adoption of pollution control practices. Finally, we also find that the relationship between substantive environmental activities and financial returns is stronger among family firms that have family members on the board and are under the influence of the first generation.