bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulation of neutrophil oxidant production and interleukin-1–related cytokines in granulomatosis with polyangiitis
Authors: Amsler Jennifer , Everts-Graber Judith , Martin Katherine R , Roccabianca Arnaud , Lopes Chloé , Tourneur Léa , Mocek Julie , Karras Alexandre , Naccache Jean-Marc , Bonnotte Bernard , Samson Maxime , Hanslik Thomas , Puéchal Xavier , Terrier Benjamin , Guillevin Loïc , Néel Antoine , Mouthon Luc , Witko-Sarsat Véronique 
Published: November 2023

Abstract

Objectives
Neutrophils play a key role in ANCA-associated vasculitis, both as targets of autoimmunity and as facilitators of vascular damage. In granulomatosis with polyangiitis (GPA), the data regarding the production of reactive oxygen species (ROS) in neutrophils are unclear. Further, recent data suggests that ROS production could have an anti-inflammatory effect through the regulation of inflammasomes and IL-1–related cytokines. We aimed to analyse ROS production in neutrophils from patients with GPA and investigate its association with IL-1–related cytokines and the autoantigen PR3.

Methods
Seventy-two GPA patients with disease flare were included in the NEUTROVASC prospective cohort study. ROS production in whole blood of patients with active GPA was evaluated and compared with that in the same patients in remission or healthy controls. Associations between ROS production, PR3 membrane expression on neutrophils, serum levels of IL-1–related cytokines as well as inflammasome-related proteins were analysed.

Results
We observed a robust defect in ROS production by neutrophils from patients with active GPA compared with healthy controls, independent of glucocorticoid treatment. Serum levels of IL-1–related cytokines were significantly increased in GPA patients, particularly in patients with kidney involvement, and levels of these cytokines returned to normal after patients achieved remission. Further, inflammasome-related proteins were significantly dysregulated in the cytosol of neutrophils as well as the serum from GPA patients.

Conclusion
Our data suggests that ROS production and regulation of inflammasomes in neutrophils from patients with GPA are disturbed and may be a potential therapeutic target.

Trial registration
ClinicalTrials.gov, https://www.clinicaltrials.gov, NCT01862068.
Fathers, daughters, and matters of trust
Authors: Morrison David 
Published: November 2023

Abstract
This article arises from a complex family dispute and some difficulty in determining the full facts underpinning the complaint. Information given by the parties grudgingly, partially, and in very poor order, caused the primary judge in the penultimate case considered herein to no doubt reluctantly prefer the daughter’s version of events over that of her father. The primary concern is whether or not the father loaned money to his daughter in the purchase of a house in her own name, giving rise to a concomitant responsibility on her part to repay the said loan, or whether, because of the nature of the arrangement, monies advanced by the father might instead be interpreted consistent with an intention on his part to have a beneficial interest in the property.
Contributors to Second-Degree Accelerated Student Success During the COVID-19 Pandemic as Perceived by Administrators, Directors, and Faculty
Authors: Fellows Bonnie J. 
Published: November 2023

Abstract

AIM
This qualitative descriptive study explored the contributors to second-degree accelerated program (SDAP) student success during COVID-19 as described by SDAP administrators, directors, and faculty.

BACKGROUND
SDAPs are fast, rigorous, and stressful. Understanding how SDAP students remain successful, despite their challenges and stressors, during the disorder of a global pandemic could provide insight for administrators, directors, and faculty on how to facilitate success in SDAP students in the future.

METHOD
A qualitative descriptive approach was used in this study. Personal interviews and a demographic survey were used for data collection.

RESULTS
Fourteen SDAP administrators, directors, and faculty participated. Six themes emerged: engagement, clinical experiences, student characteristics, relationships, flexibility, and faculty concerns.

CONCLUSION
Participants shared several recommendations to guide other SDAP administrators, directors, and faculty in developing robust SDAPs and successful students.
A Brief Online Training to Address Pharmacists' Willingness to Dispense Buprenorphine
Authors: Carpenter Delesha , Mashburn Patricia , Viracola Cheryl , Marley Grace , Ostrach Bayla 
Published: November 2023

Background
The recent passage of the Mainstreaming Addiction Treatment (MAT) Act could increase the number of patients seeking to fill buprenorphine prescriptions at community pharmacies; however, multiple barriers limit community pharmacists' ability and willingness to dispense buprenorphine. We assess whether a brief online buprenorphine training program (Buprenorphine Understanding in the Pharmacy Environment) improves community pharmacists' outcomes, including willingness to dispense buprenorphine.

Methods
A convenience sample of practicing community pharmacists participated in a 30-minute buprenorphine training. The training was codeveloped with pharmacy advisors and presented solutions to common buprenorphine dispensing barriers. Participants completed a pretest and posttest that assessed their buprenorphine knowledge (5 multiple-choice items based on training content), self-efficacy to engage in various buprenorphine-related behaviors (7 items), buprenorphine attitudes (8 items), and willingness to dispense buprenorphine to 4 different types of customers. Descriptive statistics were calculated, and paired-samples t tests were used to evaluate the impact of the training on pharmacist outcomes.

Results
Of 266 individuals who accessed the pretest, 104 responses were included in the analysis (response rate, 39%). Buprenorphine Understanding in the Pharmacy Environment improved pharmacists' mean buprenorphine knowledge scores (pretest, 2.2; posttest, 3.5; P < 0.001), all 7 self-efficacy items (all P < 0.001), mean buprenorphine attitudes (pretest, 3.1; posttest, 3.4; P < 0.001), and willingness to dispense to all four types of buprenorphine customers (all P < 0.01).

Conclusions
A brief buprenorphine training increased pharmacists' willingness to dispense buprenorphine. Although generalizability of the results may be limited by use of a convenience sample, our pharmacist-oriented training showed promising results and may be an important step in increasing availability of buprenorphine in community pharmacies.
Feel, move, or walk? Which has a greater contribution to functioning in total knee arthroplasty? A comparative study between two instrumentations based on a classification and regression tree
Authors: Fontes Ana Paula , Cintra Rui Miguel , Gomes Luís Filipe , Sousa João Paulo 
Published: November 2023

Background:
This study aimed to know which variables most contribute to the functioning acquired in the third month using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and a multivariate analysis through classification and regression tree (CRT), comparing the conventional instrumentation (CI), and patient-specific instrumentation (PSI).

Methods:
This is an observational and retrospective study. The sample consisted of 252 patients, 68 receiving CI (27.0%) and 184 receiving PSI (73.0%). The functional variables of the study were: knee pain, passive flexion and extension, gait distance and the domains of the WOMAC index.

Results:
The CRT method identified that the only explanatory variable that contributed to the highest functioning in the CI group (13.2 in the WOMAC) was pain in the third month with a value ≤2.5 in the visual analog scale (VAS). In the PSI group, the variable that best explained functioning was pain in the first postoperative month (VAS ≤4.5), with the best functional result (2.8 in WOMAC) referring to the patients who walked >320.5 m in the 6-minute walk test in the first month and who had flexion of >112.5 in the third month.

Conclusions:
Feeling pain is the variable with the most significant explanatory power for the results achieved in functioning at the third month, regardless of the arthroplasty instrumentation employed. Moving the knee in higher flexion ranges and obtaining higher mean values of gait speed also positively influences functioning in patients subjected to PSI.
Clinical Outcomes and Associated Pathologies Following Pediatric Traumatic Hip Dislocations: A Systematic Review of the Literature
Authors: Baumann Anthony N. , Ndjonko Laura C.M. , Schoenecker Jonathan G. , Baldwin Keith D. 
Published: November 2023

Introduction:
Pediatric traumatic hip dislocations are a rare condition that can have devastating short and/or long-term outcomes and associated pathologies (APs), including associated injuries (AIs) and long-term adverse events (LTAEs), with negative long-term sequelae. Currently, there are little data that exist on the rate of APs, with the most notable being avascular necrosis (AVN), for pediatric traumatic hip dislocations. The purpose of this systematic review is to evaluate the outcome relative frequency of dislocation direction, reduction type, and rate of APs for traumatic hip dislocations in the pediatric population.

Methods:
A systematic review on the topic of traumatic hip dislocations in the pediatric population was performed using PubMed, ScienceDirect, Web of Science, CINAHL, and MEDLINE databases from database inception to March 30, 2023. Inclusion criteria was full-text English articles, addressed traumatic hip dislocations, and pediatric patients (<18 y old).

Results:
A total of 24 articles (n=575 patients) met final inclusion criteria from a total of 219 articles retrieved from the initial search. For the average age of the included patients with reported age (n=433 patients), the frequency weighted mean was 9.50 years±1.75 years with a frequency weighted mean follow-up time of 74.05 months ±45.97 months (n=399 patients). The most common dislocation direction was posterior (86.4%), the most common treatment type was closed reduction (84.5%), AVN was the most common type of LTAEs (15.5% of APs), and labral/capsular injuries and acetabular fractures were the most common type of AIs (14.0% and 9.4% of APs, respectively). There were a combined total of 414 APs (72%) out of 575 total patients.

Conclusion:
Pediatric traumatic hip dislocations are associated with a high rate of AIs and LTAEs (72%, 414 APs out of 575 patients). AVN, labral/capsular injuries, and acetabular fractures are the most common APs after pediatric traumatic hip dislocations. Pediatric hip dislocations are usually posterior and commonly managed through closed reduction.

Level of Evidence:
III, Systematic Review.
Enhancing Precision in L-band Electron Paramagnetic Resonance Tooth Dosimetry: Incorporating Digital Image Processing and Radiation Therapy Plans for Geometric Correction
Authors: Park Jong In , Koo Chang Uk , Oh Jeonghun , Kim In Jung , Choi Kwon , Ye Sung-Joon 
Published: November 2023

Abstract
Following unforeseen exposure to radiation, quick dose determination is essential to prioritize potential patients that require immediate medical care. L-band electron paramagnetic resonance tooth dosimetry can be efficiently used for rapid triage as this poses no harm to the human incisor, although geometric variations among human teeth may hinder accurate dose estimation. Consequently, we propose a practical geometric correction method using a mobile phone camera. Donated human incisors were irradiated with calibrated 6-MV photon beam irradiation, and dose-response curves were developed by irradiation with a predetermined dose using custom-made poly(methyl methacrylate) slab phantoms. Three radiation treatment plans for incisors were selected and altered to suit the head phantom. The mean doses on tooth structures were calculated using a commercial treatment planning system, and the electron paramagnetic resonance signals of the incisors were measured. The enamel area was computed from camera-acquired tooth images. The relative standard uncertainty was rigorously estimated both with and without geometric correction. The effects on the electron paramagnetic resonance signal caused by axial and rotational movements of tooth samples were evaluated through finite element analysis. The mean absolute deviations of mean doses both with and without geometric correction showed marginal improvement. The average relative differences without and with geometric correction significantly decreased from 21.0% to 16.8% (p = 0.01). The geometric correction method shows potential in improving dose precision measurement with minimal delay. Furthermore, our findings demonstrated the viability of using treatment planning system doses in dose estimation for L-band electron paramagnetic resonance tooth dosimetry.
Risk factors for rehospitalization within 90 days in patients with total joint replacement: A meta-analysis
Authors: Zeng Liping , Cai Hua , Qiu Aling , Zhang Dongfu , Lin Lingying , Lian Xirong , Chen Manli 
Published: November 2023

Background:
The risk factors influencing the readmission within 90 days following total joint replacement (TJR) are complex and heterogeneous, and few systematic reviews to date have focused on this issue.

Methods:
Web of Science, Embase, PubMed, and Chinese National Knowledge Infrastructure databases were searched from the inception dates to December 2022. Relevant, published studies were identified using the following keywords: risk factors, rehospitalization, total hip replacement, total knee replacement, total shoulder replacement, and total joint replacement. All relevant data were collected from the studies that meet the inclusion criteria. The methodological quality of the studies was assessed using the Newcastle–Ottawa Scale (NOS).

Results:
Of 68,336 patients who underwent TJR, 1,269,415 (5.4%) were readmitted within 90 days. High American Society of Anesthesiologists (ASA) class (OR, 1.502; 95%CI:1.405–1.605; P < .001), heart failure (OR,1.494; 95%CI: 1.235–1.754; P < .001), diabetes (OR, 1.246; 95%CI:1.128–1.377; P < .001), liver disease (OR, 1.339; 95%CI:1.237–1.450; P < .001), drinking (OR, 1.114; 95%CI:1.041–1.192; P = .002), depression (OR, 1.294; 95%CI:1.223–1.396; P < .001), urinary tract infection (OR, 5.879; 95%CI: 5.119–6.753; P < .001), and deep vein thrombosis (OR, 10.007; 95%CI: 8.787–11.396; P < .001) showed statistically positive correlation with increased 90-day readmissions after TJR, but high blood pressure, smoking, and pneumonia had no significant association with readmission risk.

Conclusion:
The findings of this review and meta-analysis will aid clinicians as they seek to understand the risk factors for 90-day readmission following TJR. Clinicians should consider the identified key risk factors associated with unplanned readmissions and develop strategies to risk-stratify patients and provide dedicated interventions to reduce the rates of readmission and enhance the recovery process.
Autonomy-supportive environments for people with dementia: an evidence-based review
Authors: Li Jiajing 
Published: November 2023

Abstract

Objective:
As one of the core principles of person-centered care, supporting the autonomy of residents with dementia has received increasing attention worldwide. Supportive physical environments play an important role in promoting autonomy in the everyday life of residents in care facilities. However, there is no universal definition for autonomy in everyday life nor focused research on autonomy-supportive environments. Thus, this study aims to systematically review the existing evidence of autonomy-supportive design features based on a synthesized concept analysis of autonomy in everyday life.

Methods:
A synthesized concept analysis on autonomy was conducted based on related definitions of autonomy in design guidelines and environmental assessment tools of elderly care facilities. Using keywords from the concept analysis, multiple databases including PubMed, Web of Science, CINAHL, PsycINFO, and Dementia Design Info were used to carry out a systematic review of autonomy-supportive environmental design features for people with dementia. Additional guidelines and standards were manually searched. The design features supported by empirical studies and studies based on experts’ experience were extracted from the literature. The evidence intensity of each feature was assessed according to the quality and quantity of related studies.

Results:
Four domains of autonomy, freedom, independence, control, and choice emerged based on the concept analysis. Seventy-eight autonomy-supportive design features were extracted from the literature. Features are summarized into 8 categories: building layout, circulation space, living room, dining space, bathroom, bedroom, outdoor space, and details. Of design features, 60% in the category of building layout have been cross-validated by empirical studies, whereas only 25% of the overall design features have.

Conclusions:
The results of this review show that numerous design features of the physical environment can support the autonomy of people with dementia in the 4 domains. Features of building layout are well researched and the evidence intensity for the rest of design features still needs to be improved through future empirical studies.
Factors Associated With COVID-19 Vaccine Hesitancy in Rheumatology Outpatients in New York City
Authors: Barbhaiya Medha , Schneider Brandon , Levine Jonah M. , Bruce Omar , Do Huong , Siegel Caroline H. , Bykerk Vivian P. , Feldman Candace H. , Jannat-Khah Deanna , Mandl Lisa A. 
Published: November 2023

Abstract

Objective
The aim of this study was to measure COVID-19 vaccine hesitancy among rheumatology outpatients from an early COVID-19 “hotspot” during the initial period of vaccine availability.

Methods
In March 2021, a Web-based survey was sent to 7505 adults seen at a Rheumatology Division in New York City. We evaluated characteristics associated with 3 categories of COVID-19 vaccination status: declined, undecided, and willing/already received. We used multinomial logistic regression models to calculate relative risk ratios assessing predictors of vaccination status.

Results
Among 2384 (32%) respondents (80% female, 87% White, 59% with systemic rheumatic disease), 2240 (94.0%) were willing/already received COVID-19 vaccination, 88 (3.7%) were undecided, and 56 (2.3%) declined. Compared with those willing/already vaccinated, those declining or undecided were younger, more likely identified as Black or Hispanic/Latinx, and had lower household income and educational attainment. Immunosuppressive medication use did not differ among groups. After multivariable adjustment, every 1-year increase in age was associated with a 0.96 lower relative risk of declining or being undecided versus willing/already vaccinated. Respondents identifying as Black versus White had a higher relative risk ratio of being undecided (4.29 [95% confidence interval, 1.96–9.36]), as did those identifying as Hispanic/Latinx versus non-Hispanic/non-Latinx (2.81 [95% confidence interval, 1.29–6.09]). Those declining vaccination were least likely to believe in general vaccine importance or the safety and efficacy of the COVID-19 vaccine.

Conclusions
Among rheumatology patients in New York City with and without systemic rheumatic disease, COVID-19 vaccine uptake was high after its initial availability. Sociodemographic but not medication-related factors were associated with vaccine hesitancy; these findings can inform future rheumatology vaccination programs.
Association Between Herpes Simplex Virus II Infection and Rheumatoid Arthritis in US Adults
Authors: Fu Tieh-Cheng , Lin Jr-Rung , Chang Ching-Mao 
Published: November 2023

Background/Objective
The potential correlation between herpes simplex virus (HSV) and human papillomavirus (HPV) infections and rheumatoid arthritis (RA) has not been definitively established. Further research is needed to determine the relationship between the development of RA and the presence of these viral infections.

Methods
A case-control study was conducted with data from the National Health and Nutrition Examination Survey between 2009 and 2014. Our analysis examined the association between HSV I, HSV II, HPV oral polymerase chain reaction (PCR), HPV vaginal PCR, and RA. We identified adults aged 20 to 49 years with a primary diagnosis of RA using the National Health and Nutrition Examination Survey database codes (MCQ191 = 1 [years 2009–2010]; MCQ195 = 2 [years 2011–2014]) and excluded patients with incomplete data on key variables and primary outcomes.

Results
The study included 8620 patients, with 150 patients diagnosed with RA and 1500 patients without RA. Patients with RA had a significantly higher prevalence of HSV II infection compared with those without RA (36.34% vs. 24.72%, p = 0.015) after propensity score matching. No significant differences were observed for HSV I, HPV oral PCR, and HPV vaginal PCR between the 2 groups. Patients with RA were older; were more likely to be female, obese, and non-Hispanic White; and had a higher prevalence of comorbidities than those without RA.

Conclusions
This population-based propensity score–matching study provides evidence of an association between HSV II infection and RA in US adults. Further research is needed to fully elucidate the relationship between viral infections and RA, with the aim of developing effective risk reduction strategies and innovative treatments for RA.
Treatment of Pineal Region Lesions in Children
Authors: Huang Li-tian , Zhou Quan , Tong Xiaoguang 
Published: November 2023

Background:
Pineal region lesions are more common in children than adults; however, therapeutic strategies for pineal region lesions in children are controversial.

Methods:
A retrospective study involving 54 pediatric with pineal region lesions was conducted. The therapeutic strategies for lesions and hydrocephalus were classified and analyzed.

Results:
Radiotherapy of pineal region lesions was shown to result in better postoperative recovery and fewer complications in the short-term compared with lesion resection. Total resection was related to smaller lesion size, endoscopic procedures, and a better prognosis. Cerebrospinal fluid (CSF) diversion before the resection reduced hydrocephalus recurrences, whereas further lesion resection had a negative short-term influence on CSF diversion. Among the 4 therapeutic strategies to manage hydrocephalus, a third ventriculostomy (ETV) was reasonable and further resection did not have a negative impact on the ETV. The relief of hydrocephalus was also related to better postoperative recovery, a higher total resection rate, fewer complications, and a better prognosis. Logistical regression analysis indicated that lesion size and intracranial complications were predictors of outcome.

Conclusions:
For lesion treatment, total resection and radiotherapy are essential components in children. Total resection and CSF diversion before resection were beneficial, whereas further lesion resection had a negative impact on CSF diversion. For hydrocephalus treatment, ETV was shown to be the best therapeutic strategy for management of pediatric hydrocephalus. Total resection and better preoperative health status were associated with greater hydrocephalus relief. For the overall prognosis, a lack of hydrocephalus relief was associated with poor outcomes. Lesion size and intracranial complications may be the best predictors of outcome.