bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of TRF1 can accelerate aging and induce autophagy through the P53-SIRT6 pathway in glioblastoma multiforme
Authors: Hao Mingying , Nie Ziyang , Liu Siqi , Huang Xinyu , Wang Feng , Geng Xin , Wang Fei 
Published: October 2023

Abstract
Objective
To study the effect of TRF1 on the growth and proliferation of GBM and the specific underlying molecular mechanism.
Methods
First, we investigated whether TRF1 is an oncogene in GBM by bioinformatics. Next, we knocked down TRF1 in GBM cells, treated the cells with NMN (which activates SIRT6), and then investigated the growth and proliferation of the cells. And we measured the level of telomere DNA damage in these cells. Then, the biological relationship among TRF1, P53, and SIRT6 was determined by STRING database analysis, Western blotting and qRT-PCR. Finally, we examined the levels of cellular senescence and autophagy.
Results
TRF1 is an important oncogene in GBM. TRF1 knockdown significantly inhibited the growth and proliferation of GBM cells. SIRT6 contributed to reversing the TRF1 knockdown-mediated decrease in GBM cell viability. Knocking down TRF1 caused telomere damage in GBM cells, while SIRT6 attenuated this telomere damage. In GBM cells, inhibition of TRF1 decreased SIRT6 expression through the P53 pathway. In addition, knockdown of TRF1 lead to senescence and induced autophagy in GBM cells, while SIRT6 inhibited cellular aging and autophagy.
Conclusion
Knocking down TRF1 can accelerate aging and autophagy in GBM through P53-SIRT6 pathway.
Novel Optofluidic Refractometer Based on Wedge Interferometry for Handheld Testing Devices
Authors: Gaber Noha 
Published: October 2023

Abstract
Interferometric methods are known for their high sensitivity, but on the expense of their large size. By using wedge interferometry, the size can be drastically reduced while maintaining adequate detection capabilities. In this article, a miniaturized refractometer based on this interferometer type is demonstrated to be able to achieve Sensitivity of 3.65×10-5 RIE/pixel and Detection Limit of 8.7×10-5 RIE for bulk refractometry of glucose aqueous solution. The device consists of two semitransparent mirrors made of glass slide coated by sputtered Aluminum thin film, enclosing a tapered frame that maintains one mirror slightly tilted with respect to the other, and simultaneously encloses the liquid under test. This structure causes interference pattern that depends on the refractive index of the test liquid when illuminated by a collimated laser beam. Analytical modeling is developed for the structure, from which a very promising estimation of the sensitivity is evaluated that exceeds the state-of-the-art for volume refractometry, and can be achieved upon using suitable microfabrication techniques. Numerical simulations are also presented for principle validation. The proposed novel device opens a new avenue for optofluidic detection and is very suitable for point-of-care-testing and handheld devices due to its compact size, simple and cheap fabrication.
Validation and Psychometric Testing of the Arabic Version of the Mental Health Literacy Scale Among the Saudi Arabian General Population
Authors: BinDhim Nasser F. , Althumiri Nora A. , Ad-Dab’bagh Yasser , Alqahtani Mohammed M. J. , Alshayea Ahmad Kassab , Al-Luhaidan Sulaiman M. , Svendrovski Anton , Al-Duraihem Rashed Abdullah , Alhabeeb Abdulhameed Abdullah 
Published: October 2023

Abstract

Objective This study aimed to validate the Arabic Version of the Mental Health Literacy Scale (Arabic-MHLS) among the Saudi Arabian general population, assessing its internal consistency, test-retest reliability, and structural validity. Methods A total of 700 Arabic-speaking Saudi adults were randomly selected to complete the electronic questionnaire in May 2023, which generated 544 participants. Data were coded and stored in the ZdataCloud research data collection system database. Test-retest reliability was assessed using a subsample of 48 participants who completed the questionnaire twice, with a one-week interval. Structural validity was examined using confirmatory factor analysis (CFA) and Exploratory Factor Analysis (EFA). Results The Arabic-MHLS demonstrated good internal consistency (Cronbach's alpha = 0.87) and test-retest reliability (intraclass correlation coefficient = 0.89). EFA revealed a four-factor model closely resembling the model identified in the Slovenian validation of MHLS, with factor loadings ranging from 0.40 to 0.85. The four factors included knowledge of mental health disorders, knowledge of help-seeking, knowledge of self-help strategies, and knowledge of professional help also showed good internal consistency. Conclusion The Arabic-MHLS is a valid and reliable tool for assessing mental health literacy in the Saudi Arabian general population. However, further research is needed to refine the measurement tool and understand the complex relationships between mental health literacy and other mental health-related concepts. This will contribute to the development of targeted interventions and policies aimed at improving mental health literacy and promoting mental well-being in the Saudi Arabian population and beyond.
Early trajectories and moderators of autistic language phenotypes: a longitudinal study in preschoolers
Authors: Latrèche* Kenza , Godel* Michel , Franchini Martina , Journal Fiona , Kojovic Nada , Schaer Marie 
Published: October 2023

Abstract

Language difficulties in autism emerge early and significantly impact social functioning and quality of life. Despite their wide heterogeneity, autistic language abilities can be parsed into three distinct phenotypes. Language Unimpaired (LU) exhibit near-typical verbal performance, Language Impaired (LI) show significant alterations in language structure, and Minimally Verbal (MV) display limited verbal abilities. However, little is known about the early trajectories and moderators specific to each phenotype. Here, we used a longitudinal sample of 286 preschoolers with autism and 85 typically developing (aged 1.5–5.7 y.o.), yielding 1164 visits. Our cluster analysis replicated the three well-established autistic language phenotypes (LU, n = 86; LI, n = 85; MV, n = 44) and revealed their specific early trajectories. At age 2.5, LU could be identified by their higher general cognition compared to the other phenotypes, while MV were characterized by a major delay in non-verbal cognition. Moreover, the presence of early stereotyped language specifically predicted LU’s later verbal performance, while LI language outcome was improved by early behavioral intervention. In conclusion, we provided a fine-grained description of early trajectories and moderators of autistic language phenotypes in a longitudinal sample exposed to French language, paving the way toward personalized medicine to autistic language difficulties.

*The authors would like to note that Kenza Latrèche and Michel Godel contributed equally to the study.
Pediatric rectosigmoid atypical juvenile polyps presenting with anal prolapse and acute bleeding: a case report and a comprehensive review of the literature.
Authors: Montero Javier Arredondo , Vega Elena Carracedo , Lizarraga Socorro Razquin , Anaut Mónica Bronte , Hernández-Martín Sara , Piña Gina de Lima , Troyas Rosa Guarch 
Published: October 2023

Abstract
Rectosigmoid solitary juvenile polyps are benign lesions, relatively frequent in childhood. The clinical debut of a pediatric polyp with bleeding is relatively frequent, but there are very few reports of anal prolapse of polyps. We present the case of a 7-year-old female patient with no previous history who presented with anal prolapse of a polyp with acute bleeding. An urgent endoscopic examination was performed and two rectosigmoid polypoid lesions were found and resected. The anatomopathological study showed that these were two hamartomatous polyps with mild dysplasia. The patient is asymptomatic and is being followed up. The existing reports in the medical literature of this entity are scarce. In a pediatric patient with an anal prolapse, this entity should be considered in the differential diagnosis.
The importance of water depth distribution maps in the sprinkler irrigation system performance assessment
Authors: Rezayati Amir Mohammad , Liaghat Abdolmajid , Sharifipour Majid , Ghameshlou Arezoo N. 
Published: October 2023

Abstract
The assessment of sprinkler system performance is crucial in ensuring the efficient use of water resources. The commonly used indicators of the uniformity of water distribution in sprinkler systems are Christiansen's uniformity (CU) and distribution uniformity (DU) coefficients. A more comprehensive analysis of water distribution is essential in situations where the reliability of these coefficients as indicators of water distribution patterns is limited. In the present research, distribution maps of water depth were prepared from water application profiles using catch cans experiments that were carried out in the research farm of the Agriculture and Natural Resources Faculty of the University of Tehran, which is located in Alborz province. In this way, water application profile data were obtained at different operating pressures (200, 250, 300, 350, and 400 kPa). By using this data, 2D and 3D distribution maps of water depth were created due to the overlapping of sprinklers in different arrangements, spacing, and pressures. In addition, CU and DU coefficients in square, rectangular, and triangular arrangements with different spacing and pressures from 200 to 400 kPa. A total of 11,250 different simulations were calculated and analyzed. Distribution maps of water depth contribute to advancing the understanding of sprinkler irrigation system performance and aid in the optimization of water management practices.
Thermal properties of treatment wetlands operated under freezing conditions
Authors: Grebenshchykova Zhanna , Forquet Nicolas , Brisson Jacques , Lachapelle-T Xavier , Comeau Yves , Chazarenc Florent 
Published: October 2023

Abstract

The use of treatment wetlands (TWs) presents particular challenges in regions with sub-zero winter temperatures, due to reduced biological activity and risk of pipe breakage or clogging due to freezing. We studied the vertical temperature distribution in four pilot-scale TWs exposed to winter temperatures in order to determine the impact of operational system parameters and the role of insulation on heat conservation inside the filtering bed. The overall temperature pattern was similar in all wetlands, with a trend of increasing temperature from the surface toward the bottom during the cold season. No freezing was detected in the wetlands despite average daily temperatures as low as −20 °C. Influent water temperature and hydraulic loading had a stronger influence on TW temperatures in winter than air temperature. The vertical distribution of temperatures in TWs is more sensitive to hydraulic loading variation in the percolating operating condition than in the saturated flow with forced aeration configuration. Our results suggest that TW systems can remain operational under cold winter conditions provided the surface is properly insulated by vegetation, mulch and/or snow.
How Intellectual Capital Can Develop Innovation And Performance Of Accounting Study Program?
Authors: Hermawan Sigit , Fediyanto Niko , Hariyanto Wiwit , Utomo Prasetyo , Dini Amelia Nugraha 
Published: October 2023

Purpose: The purpose of this study is to explore the role of intellectual capital in developing innovation and performance of accounting study programs in Indonesia
Methodology/approach: This type of research is qualitatively interpretive. Because the researcher understands the meaning contained in the interpretation of key informants.
Findings: Human Capital is a key factor for intellectual capital to develop innovation and performance of accounting study programs. IC, both integrated and individually, plays a role in improving the performance of IAPS 4.0-based study programs
Practical implications: The results of this research can be used by the head of the accounting study program in achieving superior accreditation based on IAPS 4.0, namely by utilizing the role of intellectual capital in developing innovation and performance.
Originality/value: The originality of this research is to explore the intellectual capital component associated with the innovation component and the performance component of the IAPS 4.0-based accounting study program. This research also explores basic theories such as role theory, human capital theory, and the resources-based theory.
Point-of-care rapid immunoassay performed on voided urine, refrigerated up to 24 hours, accurately detects bacteriuria
Authors: Grant David C. , Keebaugh Audrey E. , Werre Stephen 
Published: October 2023

Abstract

OBJECTIVE
To collect voided urine from dogs with clinical signs of lower UTI and determine the diagnostic performance of a commercially available rapid immunoassay (RIA) immediately after urine collection and after refrigeration at 4 and 24 hours.

ANIMALS
40 client-owned dogs.

METHODS
Aerobic urine culture was performed on urine collected by cystocentesis. Urine samples were collected by voiding, and the RIA performed in triplicate within 30 minutes (time 0) and again in triplicate after 4 and 24 hours of refrigeration. Test precision and agreement between culture results and RIA results at each time point were determined, and factors possibly associated with false results investigated.

RESULTS
14 of 40 dogs (35%) had UTI verified by aerobic urine culture, and all had positive RIA. Three dogs had false positive RIA results. Sensitivity, specificity, positive predictive value, and negative predictive value of the RIA were 100, 88%, 82%, and 100%, respectively, and results were not different after 4 and 24 hours of refrigeration. Precision was excellent.

CLINICAL RELEVANCE
This point-of-care RIA, performed on voided urine refrigerated up to 24 hours, rapidly and accurately identifies bacteriuria in dogs with lower urinary tract clinical signs, inexpensively.
Untying the anchor for the lipopolysaccharide: lipid A structural modification systems offer diagnostic and therapeutic options to tackle polymyxin resistance
Authors: Rogga Vanessa , Kosalec Ivan 
Published: October 2023

Abstract
Polymyxin antibiotics are the last resort for treating patients in intensive care units infected with multiple-resistant Gram-negative bacteria. Due to their polycationic structure, their mode of action is based on an ionic interaction with the negatively charged lipid A portion of the lipopolysaccharide (LPS). The most prevalent polymyxin resistance mechanisms involve covalent modifications of lipid A: addition of the cationic sugar 4-amino-L-arabinose (L-Ara4N) and/or phosphoethanolamine (pEtN). The modified structure of lipid A has a lower net negative charge, leading to the repulsion of polymyxins and bacterial resistance to membrane disruption. Genes encoding the enzymatic systems involved in these modifications can be transferred either through chromosomes or mobile genetic elements. Therefore, new approaches to resistance diagnostics have been developed. On another note, interfering with these enzymatic systems might offer new therapeutic targets for drug discovery. This literature review focuses on diagnostic approaches based on structural changes in lipid A and on the therapeutic potential of molecules interfering with these changes.
Management of Pain Symptoms and Contractures in Patients with Chronic Temporomandibular Disorders and Psychosocial Comorbidities Using Gaalas Phototherapy
Authors: Svecshtarov V. , Prodanova K. , Nencheva-Sveshtarova S. 
Published: October 2023

Abstract
The most important clinical indicators of temporomandibular disorders (TMD) are pain in the temporomandibular joints, masticatory and cervical muscles, as well as a reduction in the opening capacity of the mouth. Psychosocial factors have a significant impact in the persistence of the disease and should be taken in consideration in the treatment plan. The aim of the present study was to perform clinical and statistical evaluation on the management of pain symptoms and overcome of pronounced arthro- and myogenic mandibular contractures in GAD 7 positive patients with chronic temporomandibular disorders using combined irradiation with infrared gallium-aluminum-arsenide laser (785 nm), superluminescent visible red (633 nm) and infrared (880 nm) light emitting devices.

Materials and methods.
The study included 62 individuals with various types of temporomandibular disorders, which were established using the latest diagnostic criteria – DC/TMD, 2014, revision 2020. Fifteen out of 62 patients responded positively to the GAD 7 questionnaire, which indicates depression and/or anxiety. In 8 out of these 15 cases, the presence of pain symptoms, mandibular contractures and psychosocial comorbidities exceeded 6 months. According to DC/TMD standards, these are patients with chronic temporomandibular disorders and they were the target group for our study. The average interincisal distance from this eight-member group was 27.62 mm (SD – 8.17).

Results.
The Student t-test for the dependent samples showed a significant reduction in VAS pain scores and an increased interincisal distance after phototherapy procedures.

Conclusions.
Combined phototherapy has proven to be an effective treatment of mandibular contractures, joint and muscle pain in TMD patients with psychosocial comorbid conditions.
How Sensitive and Specific are Rapid Antigen Tests for SARS-CoV-2 – The Experience of One of the Biggest Bulgarian Hospitals
Authors: Niyazi D. , Todorova T. , Stoykova Zh. , Kostadinova Ts. , Bozhkova M. , Stoeva T. 
Published: October 2023

Abstract
Rapid point-of-care tests that detect antigens specific for SARS-CoV-2 are less expensive and faster than the standard molecular methods. However, their accuracy varies widely between tests, populations and settings. We decided to assess the diagnostic precision of antigen tests for SARS-CoV-2 in a real-life hospital environment. In a cohort of 2677 hospitalized patients, we found a sensitivity of 60.2% (95% CI 57.1%-63.4%) and a specificity of 98.1% (95% CI 97.4%-98.7%) for the antigen tests when compared to RT-PCR. The accuracy of antigen testing could be acceptable in a hospital setting, especially when the result is consistent with the clinical and epidemiological context. When there is discordance between the antigen test result and the patient’s symptoms, a confirmation with molecular methods is needed.
Financial Literacy in India: A Review of Literature
Authors: Rani Mamta , Siwach Manoj 
Published: October 2023

Abstract
The paper aims to understand various concepts and dimensions of financial literacy by using literature-based analysis. The reviews included various parameters, such as the financial literacy of young people, employees, women and college students, and the impact of financial literacy on well-being and investment decisions. Secondary information was gathered from many publications, websites, research papers, and articles. In the context of India, there is still much work to be done in the domain of financial literacy. Numerous studies have revealed low levels of financial literacy among India’s different demographic segments and some studies have revealed moderate levels. Financial literacy is a difficult topic to describe and quantify. The definition and measurement of this idea are the focus of numerous investigations. Policy changes must be made to improve financial literacy at both the fundamental and advanced levels so that people can save and invest money more sensibly in the various market opportunities.
Analysis of the Stability State of Jilț North Internal Dump in the Perspective of its Ecological Reconstruction
Authors: Predoiu Mioara Brujan , Faur Florin , Lazăr Maria , Apostu Izabela-Maria 
Published: October 2023

Abstract
The national policies, in agreement with the European ones, in the energy sector, more specifically regarding the elimination of fossil fuels from the energy mix, also mean the elimination by the year 2035 of production capacities based on lignite and its replacement with natural gas or renewable sources. In this context, the lignite open pits in the Oltenia mining basin are to be closed, or at best put into conservation. Regardless of which option is chosen, one of the most important obligations of the mining operator is related to the ecological reconstruction of the mining perimeters. Thus, in the present paper, we have proposed to analyze the technical condition of Jilț North internal waste dump to ensure that the absolutely necessary stability conditions are met, before starting any type of actual ecological reconstruction works. For this purpose, the stability analyzes performed for the designed geometry of the dump at the end of productive activities are presented and a series of recommendations are made: to ensure the physical conditions necessary in the ecological reconstruction stage; regarding the choice of the type of ecological reconstruction; respectively the choice of species to ensure the success of the ecological reconstruction effort.
What is the Relationship Between Sales Growth and Insolvency Risk?
Authors: Šarlija Nataša , Šimić Sanja , Đanković Biljana 
Published: October 2023

Abstract
Sales growth is essential for an enterprise’s survival and financial growth. If an enterprise manages to achieve sales growth, its expansion can be accomplished. However, does sales growth always have only positive effects? If the enterprise is not collecting enough cash, it can miss a payment on its debt, triggering a series of events that can lead to its insolvency. The goal of the paper is to explore the relationship between an enterprise's sales growth and its insolvency. The relationship is tested empirically on the data set of 4271 SMEs in Croatia. The results confirmed that there is a relationship between sales growth and insolvency. Better indicators exist with solvent and growing SMEs than with insolvent and non-growing. Results have also shown that high growth can be at the same time a high risk. The paper contributes to a deeper understanding of the relationship between sales growth and insolvency and empirically demonstrates that sales growth over 200% per year induces the highest probability of insolvency compared to other lower levels of growth.
The Impact of Debt Financing on the Value of a Company: the Case of North Macedonian Companies
Authors: Danevska Andrijana Bojadzievska , Stanoevska Elena Parnardzieva , Dimitrieska Savica 
Published: October 2023

Abstract
The purpose of this paper is to determine the relation between a company’s indebtedness and its value. We used a sample of 20 North Macedonian companies, listed on the Macedonian Stock Exchange (MSE) mandatory listing, and the data for 6 years’ time span. In the paper, we use Panel Data models (Pooled OLS regression, Fixed and Random Effects models) to estimate the relation between debt financing and the company’s value measured by return on assets (ROA) and Tobin’s Q. According to the results of short-term debt has a statistically significant and negative impact, while the return on investments in human capital (HCROI), company’s size and current ratio have a positive and statistically significant impact on the ROA. When investigating the impact of indebtedness on a company’s value measured by Tobin’s Q, short-term and long-term debt have positive and statistically significant effects. Our research suggests that while debt increases a company’s indicators for market performance, it also decreases the company’s accounting operating performance. Therefore, when analyzing a company’s value, investors should be considering not only Tobin’s Q, which can be sometimes regarded as a market-to-book value ratio, but also to look at the fundamental ratios, such as ROA, ROE (return on equity) and EPS (earnings per share).