bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hurricane Risk Perceptions and Evacuation Decision-Making in the Postvaccine Era of COVID-19 in U.S. Coastal States Impacted by North Atlantic Hurricanes
Authors: Collins Jennifer , Dunn Elizabeth A. , Jones Rashida K. , Polen Amy , Rao Nagashree R. , Murphy Stephen , Welford Mark 
Published: November 2023

Abstract
During peak disease transmission in 2021, the compounding threat posed by the pandemic and hurricane season required coastal states to understand evacuation behaviors during a major hurricane to inform the planning process. While research relating to hurricane evacuation behavior and perceptions of risk has increased since the start of the pandemic, there is minimal understanding of how perceptions have changed now the COVID-19 vaccine is available. A total of 1075 individuals across seven U.S. coastal states participated in a study on evacuation intentions postvaccine availability. Findings revealed that most survey participants (50.9%) preferred to stay home if a major hurricane threatened their area, and only 3.9% would evacuate to a public shelter. Approximately half (56.2%) of individuals viewed the risk of being in a shelter as more dangerous than enduring hurricane hazards. When considering shelter use, nearly half of respondents (49.4%) stated they would evacuate to a shelter before the pandemic; now, only one-third (34.3%) would consider evacuating to a shelter during the pandemic. Statistically significant findings include the relationship between those who lived in evacuation zones A or B (25.5%) and the choice to shelter in place at home (40.5%) or evacuate to a hotel (36.9%). There was a statistically significant relationship between the level of education and choosing to evacuate to a hotel. Additionally, the influence of pet ownership on evacuation decision-making was found to be statistically significant. Officials can use the results of this study to strengthen community preparedness and planning strategies across diverse populations.
Effects of fibre weight fraction on the mechanical properties of bio-Composite reinforced with Alfa fibres: Experimental and numerical investigation
Authors: Boukhoulda A , Bendine K , Boukhoulda FB , Bellali MA 
Published: November 2023

This study is dedicated to conducting a comprehensive examination, both experimentally and numerically, to characterize the mechanical properties of a composite material composed of Alfa fibres and unsaturated polyester resin. In pursuit of this objective, we diligently prepared composite specimens in accordance with the ASTM D3379-75 standardization. The Alfa fibres used were prepares using a purely natural-based extraction technique, which retains approximately 78% of the composite's performance achieved through chemical treatment. The resulting composite consists of polyester resin reinforced with varying weight fractions of fibres, ranging from 0 to 18%.The test results of the manufactured bio-composite show that specimens with an 18% weight fraction offer a tensile strength of 49.749 MPa, whereas specimens with a 10% weight fraction exhibit a strength of 44.312 MPa. Additionally, the specimens with 18% fibre reinforcement exhibit a net increase in Young's modulus by 46% compared to the fibre-free composite, with Young's modulus ranging from 1469.66 MPa to 2726 MPa. When compared with composites based on fibre glass, the introduced bio-composite with 18% Alfa fibres exhibits similar stiffness to that of glass fibres. Additionally, the outcomes from the Finite Element Model (FEM) reveal a remarkable agreement with the experimental data, underscoring the practical applicability of the proposed methodology and tools for accurately simulating tensile tests in composite structures.
The clozapine conundrum: Navigating neutropenia and the pursuit of effective care in treatment-resistant schizophrenia
Authors: Kar Anindya , Nutting Thomas , Ikram Mohammad , Sullivan Charles 
Published: November 2023

Background: This case explores the challenges encountered in managing treatment-resistant paranoid schizophrenia, focusing on the limitations of using clozapine due to the risk of neutropenia. The United Kingdom Clozapine Patient Monitoring Service (UK CPMS) and its eligibility criteria are discussed, highlighting the potential benefits of expanding access to clozapine for patients who could potentially benefit from this medication. The integration of clozapine genetic testing as a personalized approach is explored, emphasizing the importance of identifying patients with a favorable genetic profile for clozapine response. Methods: Case report. Results: The case presentation of Mr. X exemplifies the difficulties faced in managing treatment-resistant schizophrenia when access to clozapine is restricted, leading to persistent negative symptoms. Conclusion: The article underscores the importance of innovative solutions and personalized care to enhance the treatment outcomes for patients with treatment-resistant paranoid schizophrenia. It acknowledges that certain restrictions of clozapine use may limit the effective management of patients with this condition.
The difference in all-cause mortality between COVID-19 patients treated with standard of care plus placebo and those treated with standard of care alone: a network meta-analysis of randomised controlled trials of immunomodulatory kinase inhibitors
Authors: Tseng Ping-Tao , Zeng Bing-Syuan , Hsu Chih-Wei , Thompson Trevor , Stubbs Brendon , Hsueh Po-Ren , Su Kuan-Pin , Chen Yen-Wen , Chen Tien-Yu , Wu Yi-Cheng , Lin Pao-Yen , Carvalho Andre F , Li Dian-Jeng , Yeh Ta-Chuan , Sun Cheuk-Kwan , Cheng Yu-Shian , Shiue Yow-Ling , Liang Chih-Sung , Tu Yu-Kang 
Published: November 2023

Objectives The aim of this network meta-analysis (NMA) was to assess whether participants assigned to a placebo and standard of care (SoC) group had different major coronavirus disease 2019 (COVID-19)-related outcomes than those assigned to SoC alone. Design Frequentist model-based NMA. Setting We searched for randomised controlled trials (RCTs) of Janus kinase/Bruton tyrosine kinase inhibitors for the management of COVID-19. Participants Patients with COVID-19 infection. Main outcome measures The primary outcome was the 28-day all-cause mortality, and secondary outcomes were: (1) use of mechanical ventilation; (2) secondary bacterial infection; (3) acceptability (i.e. drop-out rate); and (4) safety (i.e. serious adverse events). We conducted an NMA using the frequentist model. Effect sizes were estimated using odds ratios (ORs) with 95% confidence intervals (95% CIs). Results We identified 14 eligible RCTs enrolling a total of 13,568 participants with COVID-19. Participants assigned to placebo plus SoC had a significantly higher risk of 28-day all-cause mortality than those receiving SoC alone (OR = 1.39, 95% CI = 1.07–1.79). This finding did not change substantially by subgroup analysis stratified by epidemiology factor, pandemic history progression and statistical methodologic consideration. In addition, none of the treatments investigated were associated with a significantly different risk of secondary bacterial infection, acceptability or safety compared with the SoC group. Conclusions This NMA suggested a higher all-cause mortality in patients treated with placebo plus SoC compared with those treated with SoC alone. However, caution is advised in interpreting these results due to the absence of a direct head-to-head comparison. Future research should critically evaluate the necessity of placebo administration in COVID-19 RCTs and consider alternative study designs to minimise potential biases. Trial registration: The current study was approved by the Institutional Review Board of the Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (TSGHIRB No. B-109–29) and registered in PROSPERO (CRD42022376217).
Outdoor mental healthcare: What, who, why and where to?
Authors: Neil Amanda L. , Pryor Anita , Kneebone Jessica , Flies Emily J. ,   On behalf of The Nature Effect team
Published: November 2023

Objective: Outdoor mental healthcare can increase the breadth of multidisciplinary interventions available to people with a therapeutic need. The aim of this article is to educate readers about the field of outdoor mental healthcare through the exploration of a series of basic questions. Conclusions: Outdoor mental healthcare spans a range of therapies that apply a variety of theoretical approaches and treatments across a multiplicity of settings, patient groups and desired outcomes unified by key evidence-informed practice elements. Through use of a predominantly non-mainstream workforce working in non-conventional clinical settings outdoor mental healthcare may contribute to treatment accessibility and acceptability.
MSX1 Gene Polymorphisms in Patients with non-Syndromic Cleft lip and Palate: A Tertiary Care Centre Based Case-Control Study from Central Kerala
Authors: Jyothish Arun , George Alex , Narayanan Puthucode V. , Krishnamurthy Rajanikant Golgodu 
Published: November 2023

Objective The purpose of this study was to investigate the contribution of MSX1 gene polymorphisms to the risk of developing NSCLP. Design Case-Control Study. Setting A tertiary care centre. Patients/Participants The sample consisted of 200 subjects (100 cases and 100 controls). Interventions None. Main Outcome Measure(s) Genotyping was performed by restriction fragment length polymorphism. Allele and genotype frequencies were calculated between patients and controls and analyzed using online Web Tools such as SISA and SNPstats. The MSX1 gene polymorphisms c. 799 GT, c.458 CA can be risk factors in the development of orofacial clefts. Results In the cases, an association was found between NSCLP and c.799 and c.458 of the MSX1 gene when compared with the control. The dominant and overdominant models, c. 799 GT, c.458 CA genotypes and c. 799 T, c.458 A alleles in the population are said to be the main risk factors to develop the NSCLP in our study population. The genotype variation of c 799 G/T and c.458 C/A are revealed to be specifically contributing to an NSCLP-type Cleft lip and Palate. It is worth noting that NSCLP females in the study population showed a stronger association with heterozygous genotypes of c.799 and c.458. However, further investigation with a larger cohort is necessary to confirm these findings. Conclusion Overall the results of the study revealed that MSX1 c 799 G > T and c.458 C > A can be considered as one of the genetic risk factors in the formation of Non-Syndromic Cleft Lip and Palate in the study population.
Socioeconomic Predictors of Crisis and Clinical Pathways Among People Contacting a Mental Health Crisis Line
Authors: McCarthy Molly , McIntyre Jason C , Nathan Rajan , Ashworth Emma L , Saini Pooja 
Published: November 2023

Objective: Crisis lines are the first mental health service contact point for many people, making them a vital community and public health intervention. Given the current and potential utility of crisis lines, better understanding the characteristics, socioeconomic factors and subsequent referral pathways of callers is critical to identifying targeted ways to improve such services. Study Design: The dataset captured calls to the Cheshire & Wirral Partnership NHS Foundation Trust (CWP) crisis line between August 2020 and August 2021. Calls were examined if self-harm, risk to self, or overdose were reported by the caller. Descriptive analyses were conducted to produce a clinical and demographic profile of the callers using the crisis line. Results: Call handlers were significantly more likely to call 999, hand over to a practitioner and less likely to provide advice and guidance if self-harm, risk to self or overdose was reported. Social issues were found to be significantly associated with all 3 outcomes: self-harm, risk to self and overdose. Conclusion: The current study provides the first exploratory analysis of the socioeconomic factors and resultant care pathways for those contacting a UK crisis line service. The findings have important implications for community early intervention efforts to reduce self-harm and suicidal behaviours.
Evaluation of a Court-Ordered Violence Prevention Program for Gun-involved Youths
Authors: Hipple Natalie Kroovand , Lentz Theodore S. 
Published: November 2023

As youth gun violence continues to plague marginalized US communities, knowledge about “what works” to prevent injury and illegal gun activity within this population remains a contentious and pressing issue. This study investigates the impacts of Project Life—an education-based youth gun violence prevention program—on recidivism outcomes for a sample of 368 youths in Indianapolis, Indiana, between 2015 and 2019. We conducted retrospective outcome analyses to compare youths who completed the program (83%) to youths who did not complete the program. We find that youths who completed the program were significantly less likely to recidivate with a gun violence offense within an average follow-up period of 1.5 years following enrollment in the program. Youths who spent more time incarcerated and had a parent who was incarcerated were at higher recidivism risk when controlling for prior history of offending and other key risk factors. These nonexperimental findings show short-term promise for education-based violence prevention programming for youths at risk with fewer concerns of widening the net of carceral punishment.
ERS technical standard: Global Lung Function Initiative reference values for exhaled nitric oxide fraction (FENO50)
Authors: Högman Marieann , Bowerman Cole , Chavez Luis , Dressel Holger , Malinovschi Andrei , Radtke Thomas , Stanojevic Sanja , Steenbruggen Irene , Turner Steve , Dinh-Xuan Anh Tuan 
Published: November 2023

BackgroundElevated exhaled nitric oxide fraction at a flow rate of 50 mL·s−1(FENO50) is an important indicator of T-helper 2-driven airway inflammation and may aid clinicians in the diagnosis and monitoring of asthma. This study aimed to derive Global Lung Function Initiative reference equations and the upper limit of normal forFENO50.MethodsAvailable individualFENO50data were collated and harmonised using consensus-derived variables and definitions. Data collected from individuals who met the harmonised definition of “healthy” were analysed using the generalised additive models of location, scale and shape (GAMLSS) technique.ResultsData were retrospectively collated from 34 782 individuals from 34 sites in 15 countries, of whom 8022 met the definition of healthy (19 sites, 11 countries). Overall, height, age and sex only explained 12% of the between-subject variability ofFENO50(R2=0.12).FENOdevice was neccessary as a predictor ofFENO50, such that the healthy range of values and the upper limit of normal varied depending on which device was used. The range ofFENO50values observed in healthy individuals was also very wide, and the heterogeneity was partially explained by the device used. When analysing a subset of data in whichFENO50was measured using the same device and a stricter definition of health (n=1027), between-site heterogeneity remained.ConclusionAvailableFENO50data collected from different sites using different protocols and devices were too variable to develop a single all-age reference equation. Further standardisation ofFENOdevices and measurement are required before population reference values might be derived.
PRANA: an R package for differential co-expression network analysis with the presence of additional covariates
Authors: Ahn Seungjun , Datta Somnath 
Published: November 2023

Abstract
Background
Advances in sequencing technology and cost reduction have enabled an emergence of various statistical methods used in RNA-sequencing data, including the differential co-expression network analysis (or differential network analysis). A key benefit of this method is that it takes into consideration the interactions between or among genes and do not require an established knowledge in biological pathways. As of now, none of existing softwares can incorporate covariates that should be adjusted if they are confounding factors while performing the differential network analysis.

Results
We develop an package which a user can easily include multiple covariates. The main function in this package leverages a novel pseudo-value regression approach for a differential network analysis in RNA-sequencing data. This software is also enclosed with complementary functions for extracting adjusted p-values and coefficient estimates of all or specific variable for each gene, as well as for identifying the names of genes that are differentially connected (DC, hereafter) between subjects under biologically different conditions from the output.

Conclusion
Herewith, we demonstrate the application of this package in a real data on chronic obstructive pulmonary disease. is available through the CRAN repositories under the GPL-3 license: https://cran.r-project.org/web/packages/PRANA/index.html.
Host-microbiota-parasite interactions in two wild sparid fish species, Diplodus annularis and Oblada melanura (Teleostei, Sparidae) over a year: a pilot study
Authors: Scheifler Mathilde , Magnanou Elodie , Sanchez-Brosseau Sophie , Desdevises Yves 
Published: November 2023

Abstract
Background
The microbiota in fish external mucus is mainly known for having a role in homeostasis and protection against pathogens, but recent evidence suggests it is also involved in the host-specificity of some ectoparasites. In this study, we investigated the influence of seasonality and environmental factors on both fish external microbiota and monogenean gill ectoparasites abundance and diversity and assessed the level of covariations between monogenean and bacterial communities across seasons. To do so, we assessed skin and gill microbiota of two sparid species, Oblada melanura and Diplodus annularis, over a year and collected their specific monogenean ectoparasites belonging to the Lamellodiscus genus.

Results
Our results revealed that diversity and structure of skin and gill mucus microbiota were strongly affected by seasonality, mainly by the variations of temperature, with specific fish-associated bacterial taxa for each season. The diversity and abundance of parasites were also influenced by seasonality, with the abundance of some Lamellodiscus species significantly correlated to temperature. Numerous positive and negative correlations between the abundance of given bacterial genera and Lamellodiscus species were observed throughout the year, suggesting their differential interaction across seasons.

Conclusions
The present study is one of the first to demonstrate the influence of seasonality and related abiotic factors on fish external microbiota over a year. We further identified potential interactions between gill microbiota and parasite occurrence in wild fish populations, improving current knowledge and understanding of the establishment of host-specificity.
CsBPC2 is essential for cucumber survival under cold stress
Authors: Meng Di , Li Shuzhen , Feng Xiaojie , Di Qinghua , Zhou Mengdi , Yu Xianchang , He Chaoxing , Yan Yan , Wang Jun , Sun Mintao , Li Yansu 
Published: November 2023

AbstractCold stress affects the growth and development of cucumbers. Whether the BPC2 transcription factor participates in cold tolerance and its regulatory mechanism in plants have not been reported. Here, we used wild-type (WT) cucumber seedlings and two mutant Csbpc2 lines as materials. The underlying mechanisms were studied by determining the phenotype, physiological and biochemical indicators, and transcriptome after cold stress. The results showed that CsBPC2 knockout reduced cucumber cold tolerance by increasing the chilling injury index, relative electrical conductivity and malondialdehyde (MDA) content and decreasing antioxidant enzyme activity. We then conducted RNA sequencing (RNA-seq) to explore transcript-level changes in Csbpc2 mutants. A large number of differentially expressed genes (1032) were identified and found to be unique in Csbpc2 mutants. However, only 489 down-regulated genes related to the synthesis and transport of amino acids and vitamins were found to be enriched through GO analysis. Moreover, both RNA-seq and qPT-PCR techniques revealed that CsBPC2 knockout also decreased the expression of some key cold-responsive genes, such as CsICE1, CsCOR413IM2, CsBZR1 and CsBZR2. These results strongly suggested that CsBPC2 knockout not only affected cold function genes but also decreased the levels of some key metabolites under cold stress. In conclusion, this study reveals for the first time that CsBPC2 is essential for cold tolerance in cucumber and provides a reference for research on the biological function of BPC2 in other plants.
Prognostic value of albumin to fibrinogen ratio for mortality in patients with hypertrophic cardiomyopathy
Authors: Li Liying , Ban Chao , Ruan Haiyan , Zhang Muxin , Wang Ziqiong , Ma Min , Zheng Yi , He Sen 
Published: November 2023

Abstract
Background
Albumin to fibrinogen ratio (AFR), a new inflammatory marker, has emerged as a useful indicator to predict adverse outcomes for several diseases. However, whether AFR could be a new useful indicator to predict mortality in HCM patients remains to be evaluated. The study explored the predictive value of AFR for HCM-related death in adult HCM patients.

Methods
A total of 404 HCM patients were eventually enrolled in the study according to the inclusion criteria. Patients were divided into two groups based on the median of baseline AFR. The association between AFR and HCM-related death was analyzed.

Results
During a median follow-up of 4.75 years, HCM-related death was observed in 45 patients (11.1%). The incidence of HCM-related death was significantly higher in the low AFR group (log-rank p < 0.001). With the high AFR group as reference, the unadjusted hazard ratio (HR) for HCM-related death was 2.97 (95% confidence interval [CI]: 1.53–5.75, p = 0.001) in the low AFR group, and after adjusting for potentially confounding variables, the adjusted HR for low AFR group was 3.15 (95% CI: 1.56–6.37, p = 0.001). No significant interactions between AFR and other variables were observed in subgroup analysis. Sensitivity analyses in patients with normal albumin and fibrinogen showed similar results.

Conclusion
AFR is an independent prognostic factor for HCM-related death, adult HCM patients with a lower AFR have a higher risk of HCM-related death.