bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modification Effects of Albuminuria on the Association Between Kidney Function and Development of Anemia in Diabetes
Authors: Okada Akira , Yamaguchi Satoko , Imaizumi Takahiro , Oba Koji , Kurakawa Kayo Ikeda , Yamauchi Toshimasa , Kadowaki Takashi , Nangaku Masaomi 
Published: November 2023

Abstract

Context
Previous studies failed to adjust for estimated glomerular filtration rate (eGFR) in evaluating the association between albuminuria and anemia development, and we aimed to investigate whether albuminuria independently affects anemia development.

Methods
We conducted a retrospective cohort study and retrospectively identified adults with diabetes from a Japanese nationwide clinical database (JMDC, Tokyo, Japan). To assess the modification effects of albuminuria on the association between eGFR and anemia development, we estimated prevalence of anemia, defined as hemoglobin &lt; 13 g/dL in men and &lt; 12 g/dL in women, using a modified Poisson regression and marginal standardization form of predictive margins, stratified by albuminuria severity after adjusting for eGFR. Hence, we revealed at which eGFR level this modification effect appeared and the extent to which this modification effect increased the prevalence of anemia.

Results
We identified 327 999 data points from 48 056 individuals [normoalbuminuria: 186 472 (56.9%), microalbuminuria: 107 170 (32.7%), and macroalbuminuria: 34 357 (10.5%)]. As eGFR declined, anemia prevalence increased. Albuminuria severity modified this association induced by decreased eGFR among individuals with eGFR &lt;30 mL/min/1.73 m2 after adjusting for multivariable factors, including age, sex, comorbidities, and medication use. Compared with the normoalbuminuric group, the macroalbuminuric group had a 5% to 20% higher anemia prevalence among individuals with eGFR of &lt;30 mL/min/1.73 m2.

Conclusion
We revealed that the severity of albuminuria modified the association between eGFR and anemia development among individuals with eGFR &lt;30 mL/min/1.73 m2, highlighting the modification effect of albuminuria on the association between kidney function and anemia development in diabetes.
Functions of demonstrative pronouns in contemporary Soikkola Ingrian
Authors: Markus Elena , Rozhanskiy Fedor 
Published: November 2023

This article discusses demonstrative pronouns in the Soikkola dialect of the Ingrian language. The material for the research comes from the collection of spontaneous speech samples recorded in the 21st century. All the examples are published for the first time. The article presents mainly a qualitative analysis and aims at overviewing the basic functions of the Ingrian demonstrative pronouns tämä and še. It is shown that in the contemporary Ingrian the demonstratives are used as deictic and anaphoric devices, and also as discourse markers. Individual speakers demonstrate differences in the use of these pronouns due to the contact influence from the neighbouring languages.

Kokkuvõte. Elena Markus, Fedor Rozhanskiy: Demonstratiivpronoomenite funktsioonid tänapäeva isuri keele Soikkola murdes. Käesolevas artiklis käsitletakse demonstratiivpronoomeneid isuri keele Soikkola murdes. Uurimuse materjal pärineb 21. sajandil salvestatud spontaanse kõne näidiste kogust. Kõik näited avaldatakse esimest korda. Artiklis esitatakse peamiselt kvalitatiivne analüüs ja selle eesmärk on anda ülevaade isuri demonstratiivpronoomenite tämä ja še põhifunktsioonidest. Näidatakse, et tänapäeva isuri keeles kasutatakse demonstratiive deiktiliste ja anafoorsete vahenditena ning ka diskursuse markeritena. Üksikutel kõnelejatel esineb nende asesõnade kasutamisel erinevusi naaberkeelte kontaktmõju tõttu.
Dichotomy of Tranquility and Annoyance Strategies as Background for the Communicative Behavior of German Haiku Poets
Authors: Dacko D. 
Published: November 2023

Introduction. The article considers the genre of German haiku as an element of a communicative act stipulating certain dialogue between the addresser (haiku poet) and the recepient (reader).
The aim of research is to identify communicative strategies and tactics representing the communicative behavior of contemporary haiku authors. Methodology and research methods. The research work used methods of systematization and generalization of the scientific material, descriptive-analytical method, method of linguistic and stylistic analysis of the text. Results. It has been shown that the author's intention in the texts of modern German haiku is explicated through two basic strategies — tranquility and annoyance. Each strategy is represented by a set of main tactics. In particular, the strategy of tranquility includes tactics of observation and adaptation, the strategy of annoyance involves tactics of breaking the taboo topics, intimidation, and creating a negative mood.
In the 21st century, due to the haiku genre evolution and transformation of the social values it is possible to adopt a micro-diachronic approach to the research of changes in the communicative behavior of haiku poets in the light of the communicative strategies dichotomy. Previously haiku poems were composed exclusively according to the canons of Japanese poetry. This fact also determines the relevance of the study.
Scientific novelty lies in the study of the specifics of communicative strategies and tactics, the norms of artistic communication in terms of German haiku genre.
The practical significance is determined by the possibility of using the obtained scientific results in special university basic courses on literary translation, discourse theory, linguistic and stylistic interpretation of the text.
VIRTUAL TOUR IN AN INNOVATIVE FORMAT OF COMMUNICATIVE TEACHING OF THE RUSSIAN LANGUAGE
Authors: Deykina Alevtina , Levushkina Ol'ga , Ryauzova Olga 
Published: November 2023

Introduction. The active search for new forms and means of teaching that enrich the teaching process and improve the quality of educational activities has led to the renewal of the arsenal of methodological tools in the methodology of the Russian language. Orientation to the development of students' communicative competence, reliance on system-activity, personality-oriented and communicative-activity approaches, active use of information and communication technologies in the learning process has led to the emergence of innovative forms and methods of communicative teaching of the Russian language. In this context, a virtual tour has become an important and relevant methodological tool.
Aim. The purpose of this methodological study is to identify the educational potential of a virtual excursion in the process of communicative teaching of the Russian language.
Methods: analysis, generalization, modeling.
Results. The formation of this concept in the scientific and methodological literature, the specifics of using virtual excursions in the methodology of teaching Russian as a foreign language and as a native language are analyzed. The methodological potential of virtual excursions is shown, in the process of using which modern educational technologies (design and research and global simulation technology) can be integrated. The linguodidactic potential of virtual excursions for the intellectual, communicative and cultural development of students is described.
Scientific novelty. Virtual tour is presented as an innovative form of communicative teaching of the Russian language, as a modern teaching method and as an innovative format of a modern Russian language lesson.
Practical significance. The results of this study can be used in the practice of communicative teaching of Russian as a native and as a foreign language.
ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells
Authors: Bian Meng , Li Shan , Zhou Hanzong , Bi Lijun , Shen Yong , Tingjin Chen , Yu Xinbing , Huang Yan , Xu Qingxia 
Published: November 2023

Background
Clonorchiasis, caused by the infection of Clonorchis sinensis (C. sinensis), is a kind of neglected tropical disease, but it is highly related to cholangiocarcinoma. It has been well known that NO from chronic inflammation responses are thought to be a major component of the damage and ultimate carcinogenesis ESPs such as nitric oxide synthase interacting protein (NOSIP) are thought to enhance the damage. The objective of this study was to identify the protein candidates interact with recombinant CsNOSIP (rCsNOSIP) and explore their role involved in CCA development or progression.

Methods
We applied HuProt microarray containing 21,000 probe sets for a systematic identification of rCsNOSIP-binding proteins and grouped binding hits by gene function. Pull-down assays were used to confirm the interaction of rCsNOSIP with alveolar soft part sarcoma (ASPSCR-1) and sirtuins 5 (Sirt-5). ASPSCR-1/Sirt-5 over-expression and siRNA knockdown experiments were employed for obtain of ASPSCR-1/Sirt-5 high or low expression (ASP-oe/Sirt5-oe or ASP-si/Sirt5-si) cholangiocarcinoma cell line (CCLP-1) cells. Nitric oxide (NO) and reactive oxygen species assay (ROS) as well as cell proliferation and wound-healing assays were performed to observe the effect of rCsNOSIP on ASP-oe/Sirt5-oe or ASP-si/Sirt5-si CCLP-1 cells.

Results
Seventy candidate proteins protein "hits" were detected as rCsNOSIP-binding proteins by HuProt microarray and bioinformatics analysis. Pull down assay showed that ASPSCR-1 and Sirt-5 could interact with rCsNOSIP. In addition, endotoxin-free-rCsNOSIP could increase the production of NO and ROS and promote the migration of CCLP-1 cells, while its effect on enhancing cell proliferation was not significant. Furthermore, ROS/NO production, proliferation, or migration were increased in ASP-si or Sirt5-si CCLP-1 cells but decreased in Asp-oe or Sirt5-oe CCLP-1 cells when stimulated with rCsNOSIP.

Conclusions
Our findings suggest that CsNOSIP as a component of CsESPs might promote the development and invasion of CCA and Sirt5/ ASPSCR1 as host molecules might play a novel protective role against adverse stimulus during C. sinensis infection. This work supports the idea that CsESPs induce the occurrence and progression of CCA through ROS/RNS-induced oxidative and nitrative DNA damage.
Snakebite epidemiology, outcomes and multi-cluster risk modelling in Eswatini
Authors: Padidar Sara , Monadjem Ara , Litschka-Koen Thea , Thomas Brent , Shongwe Nondusimo , Baker Clare , Mmema Lindelwa , Sithole Trevor , Murray James , Casewell Nicholas R. , Pons Jonathan , Lalloo David G. , Harrison Robert A. , Stienstra Ymkje , Dlamini Wisdom M. 
Published: November 2023

Background
Halving snakebite morbidity and mortality by 2030 requires countries to develop both prevention and treatment strategies. The paucity of data on the global incidence and severity of snakebite envenoming causes challenges in prioritizing and mobilising resources for snakebite prevention and treatment. In line with the World Health Organisation’s 2019 Snakebite Strategy, this study sought to investigate Eswatini’s snakebite epidemiology and outcomes, and identify the socio-geographical factors associated with snakebite risk.

Methodology
Programmatic data from the Ministry of Health, Government of Eswatini 2019–2021, was used to assess the epidemiology and outcomes of snakebite in Eswatini. We developed a snake species richness map from the occurrence data of all venomous snakes of medical importance in Eswatini that was subjected to niche modelling. We formulated four risk indices using snake species richness, various geospatial datasets and reported snakebites. A multivariate cluster modelling approach using these indices was developed to estimate risk of snakebite and the outcomes of snakebite in Eswatini.

Principal findings
An average of 466 snakebites was recorded annually in Eswatini. Bites were recorded across the entire country and peaked in the evening during summer months. Two cluster risk maps indicated areas of the country with a high probability of snakebite and a high probability of poor snakebite outcomes. The areas with the highest rate of snakebite risk were primarily in the rural and agricultural regions of the country.

Significance
These models can be used to inform better snakebite prevention and treatment measures to enable Eswatini to meet the global goal of reducing snakebite morbidity and mortality by 50% by 2030. The supply chain challenges of antivenom affecting southern Africa and the high rates of snakebite identified in our study highlight the need for improved snakebite prevention and treatment tools that can be employed by health care workers stationed at rural, community clinics.
Publicity governance in contingency management during the COVID-19 pandemic in China: A “Government-Society” perspective
Authors: Wang Mengdi , Peng Xiaobing 
Published: November 2023

Background
Publicity is a common form of governance in government and is even more important in contingency management, especially during the COVID-19 pandemic. Publicity has two sides, the main body of publicity is led by the government, the object of publicity is the response to the public. So, publicity exists in the "government-society" field. Our aim was to find out how governments have been able to achieve effective publicity in the COVID-19 and to promote the active participation of society in governance.

Materials and methods
We adopted a case study approach. Taking Chongqing Municipality as an example, we collected 201 messages from five forms of publicity, including cell phone SMS, village (community) broadcast, publicity placards or banners, official websites, and government media platforms during the period of 2020–2021, and described and analyzed the publicity content of different forms of publicity.

Results
During the whole period of the COVID-19, the publicity governance under contingency management showed the characteristics of focusing on administrative efficiency, social efficiency and post-social efficiency, and showed specific publicity governance functions such as mobilization and control, education and clarification, cultivation of public consciousness and shaping government credibility.

Conclusions
Publicity governance in contingency management during the COVID-19 pandemic emphasizes three effective approaches: time synchronization, organizational scale, and interaction among multiple advocacy agents. This can extend the existing government-centered research to the level of interaction between the government and society, and help the government to better use effective publicity to achieve the governance task under contingency management.
Feasibility and effect of high-intensity training on the progression of motor symptoms in adult individuals with Parkinson’s disease: A systematic review and meta-analysis
Authors: Sena Ingrid Garcia De , Costa Adalberto Veronese da , Santos Isis Kelly dos , Araújo Dayane Pessoa de , Gomes Francisca Tayná da Silva , Cavalcanti José Rodolfo Lopes de Paiva , Knackfuss Maria Irany , Andrade Micássio Fernandes de , Melo Paloma Katlheen Moura , Fonseca Ivana Alice Teixeira 
Published: November 2023

Background
To determine the feasibility and effect of high-intensity interval training (HIIT) in individuals with Parkinson’s and their effect on symptom modification and progression.

Methods
We conducted this systematic review following the Preferred Reporting Items for systematic review and meta-analysis (PRISMA). All studies were searched in seven databases: MEDLINE (PubMed), Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, SPORTDiscus, Virtual Health Library (VHL) and SCOPUS in September 2020 and updated in June 2023. The risk of bias was assessed by the Cochrane Collaboration tool and Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool. We used standardized mean difference (SMD) with a 95% confidence interval (CI) and random effects models, as well as the non-parametric Cochran’s Q test and I2 inconsistency test to assess heterogeneity.

Results
A total of 15 randomized clinical trials with 654 participants (mean age, 65.4 years). The majority of studies included high intensity training interventions versus moderate intensity, usual care, or control group. The meta-analysis comparing high-intensity exercise versus control group showed an improvement in the disease severity (MD = -4.80 [95%CI, -6.38; -3.21 high evidence certainty); maximum oxygen consumption (MD = 1.81 [95%CI, 0.36; 3.27] very low evidence certainty) and quality of life (MD = -0.54 [95%CI, -0.94; -0.13] moderate evidence certainty). The results showed that high-intensity exercise compared with moderate intensity exercise group showed a improve motor function and functional mobility measured by the TUG test (MD = -0.38 [95%CI, -0.91; 0.16] moderate evidence certainty) with moderate heterogeneity between studies.

Conclusion
High-intensity exercise performed in both continuous and interval modes when compared with control groups may provide motor function benefits for individuals with Parkinson’s disease. HIIT may be feasible, but the intensity of the exercise may influence individuals with Parkinson’s disease. However, there was a lack of evidence comparing high intensity and moderate intensity for this population, as the results showed heterogeneity.
Effect of MEF2A and SLC22A3-LPAL2-LPA gene polymorphisms on warfarin sensitivity and responsiveness in Jordanian cardiovascular patients
Authors: AL-Eitan Laith N. , Almasri Ayah Y. , Alnaamneh Adan H. , Mihyar Ahmad 
Published: November 2023

Aims
This study aims to investigate the influence of MEF2A and SLC22A3-LPAL2-LPA polymorphisms on cardiovascular disease susceptibility and responsiveness to warfarin medication in Jordanian patients, during the initiation and maintenance phases of treatment.

Backgrounds
Several candidate genes have been reported to be involved in warfarin metabolism and studying such genes may help in finding an accurate way to determine the needed warfarin dose to lower the risk of adverse drug effects, resulting in more safe anticoagulant therapy.

Methods
The study population included 212 cardiovascular patients and 213 healthy controls. Genotyping of MEF2A and SLC22A3-LPAL2-LPA polymorphisms was conducted to examine their effects on warfarin efficiency and cardiovascular disease susceptibility using PCR-based methods.

Results
One SNP (SLC22A3-LPAL2-LPA rs10455872) has been associated with cardiovascular disease in the Jordanian population, whereas the other SNPs in the MEF2A gene and SLC22A3-LPAL2-LPA gene cluster did not have any significant differences between cardiovascular patients and healthy individuals. Moreover, SLC22A3-LPAL2-LPA rs10455872 was correlated with moderate warfarin sensitivity, the other SNPs examined in the current study have not shown any significant associations with warfarin sensitivity and responsiveness.

Conclusion
Our data refer to a lack of correlation between the MEF2A polymorphism and the efficacy of warfarin treatment in both phases of treatment, the initiation, and maintenance phases. However, only rs10455872 SNP was associated with sensitivity to warfarin during the initiation phase. Furthermore, rs3125050 has been found to be associated with the international normalized number treatment outcomes in the maintenance phase.
In (Partial) Defence of the Monologue Sermon
Authors: MacBride Tim 
Published: November 2023

Abstract
This paper argues for the retention of the monologue sermon as an effective means of congregational formation, against a background of increasing criticism. Firstly, it allows for sustained focus on a topic in ways that discussion-based alternatives do not. Secondly, it appropriately values expertise and godly authority in a culture which has subjectivised truth and devalued expertise. Thirdly, it can allow congregations to hear voices they otherwise would not. Fourthly, it models the hermeneutical process for the congregation. Finally, as a sober address on behalf of God, it has permission to issue confronting challenges.
The quality and quantity of compounds affected by viral inactivation methods in dried blood spots
Authors: Wang Ming , Yu Chaowen , Tang Shi , Liao Zhihong , Wan Kexing , Liu Shan 
Published: November 2023

Abstract

Objectives
The aim is to evaluate the effect of viral inactivation methods on the quality and quantity of compounds in dried blood spots (DBS).

Methods
Three effective and common inactivation methods were selected via the literature search, including: heating at 56 °C for 30 min, irradiation with UVC for 30 min, and surface wetting with 70 % ethanol. The concentration and clinical predicting significance of hormones, amino acids, and acylcarnitines from DBS were assessed, and the quality and quantity of extracted deoxyribonucleic acid (DNA) from DBS were evaluated.

Results
Compared to control, we found that there was no significant difference on hormones concentration in the DBS treated by heating at 56 °C for 30 min (thyroid stimulating hormone p=0.36, 17-hydroxyprogesterone p=0.52). And heating at 56 °C for 30 min had a minimal changed coefficient of variation on the concentration of amino acids and acylcarnitines. All three inactivation methods slightly changed the yield of DNA extraction, but did not affect the quality of the DNA. Importantly, the three inactivation methods wouldn’t change the clinical predicting significance of above-compounds mostly, especially heating at 56 °C for 30 min.

Conclusions
Considering the minimal effect on the quality and quantity of various compounds, the contaminated DBS could be pretreated by the three inactivation methods, as temporary emergency inactivation methods, especially heating at 56 °C for 30 min.
Honey and the Indecency of Epicurus’aurea dicta(DRN3.12)
Authors: Pope Michael 
Published: November 2023

AbstractIn this article theaurea dictaof Epicurus (DRN3.12) are placed in conversation with larger discourses related to apian, floral, and honey imagery. Within these literary contexts, bees and honey are often associated with morally suspect appetites, effeminacy, and potentially dangerous erotic entanglements. Lucretius, I argue, seems to allude to these risky literary valences and manipulates them for his own poetic and rhetorical ends. Honey, we discover, is much more than a sugary substance.
Effects of cold deformation modes on microstructure uniformity and mechanical properties of large 2219 Al–Cu alloy rings
Authors: Guo Wanfu , Yi Youping , Ruan Jinhua , Liu Changming 
Published: November 2023

Abstract
The mechanical properties of large 2219 Al–Cu alloy rings need to be further improved with the diameter of the launch vehicle being more than 10 m. In this study, the effects of cold rolling (CR) and cold compression on microstructure evolution and the comprehensive mechanical properties of such rings were compared. The evolution of dislocation characteristics, grain structure, second phase, and the mechanical properties of the T8-aged samples were examined. Results show that compared with CR, because of deformation characteristics, cold compression deformation induces less increase in dislocation densities; however, the increase in dislocation densities on the core was higher than at other positions, resulting in a more uniform grain structure and elongation in the axial and radial direction. The cold compression deformation contributes to the uniform dissolution of the secondary phase, resulting in denser precipitates, and thus improved strength. Brittle fractures occur in fewer CR samples because of the longer moving distance of the Al matrix. In summary, both CR and cold compression can improve the mechanical properties. However, the cold-compressed sample exhibits more uniform microstructure and higher comprehensive mechanical properties (the radial elongation increased from 7.1 to 11.2%; the in-plane anisotropy decreased from 36.6 to 8.9%), without any brittle fractures, because of more uniform metal flow.