bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is trait rumination associated with affective reactivity to the menstrual cycle? A prospective analysis
Authors: Tauseef Hafsah A. , Schmalenberger Katja M. , Barone Jordan C. , Ross Jaclyn M. , Peters Jessica R. , Girdler Susan S. , Eisenlohr-Moul Tory A. 
Published: January 2024

AbstractBackgroundA minority of naturally cycling individuals experience clinically significant affective changes across the menstrual cycle. However, few studies have examined cognitive and behavioral constructs that may maintain or worsen these changes. Several small studies link rumination with premenstrual negative affect, with authors concluding that a tendency to ruminate amplifies and perpetuates hormone-sensitive affective symptoms. Replication in larger samples is needed to confirm the validity of rumination as a treatment target.Method190 cycling individuals (M = 30.82 years; 61.1% Caucasian) were recruited for moderate perceived stress, a risk factor for cyclical symptoms. They completed the Rumination Response Scale at baseline, then reported daily affective and physical symptoms across 1–6 cycles. Multilevel growth models tested trait rumination as a predictor of baseline levels, luteal increases, and follicular decreases in symptoms.ResultsThe degree of affective cyclicity was normally distributed across a substantial range, supporting feasibility of hypothesis tests and validating the concept of dimensional hormone sensitivity. Contrary to prediction, higher brooding did not predict levels or cyclical changes of any symptom. In a subsample selected for luteal increases in negative affect, brooding predicted higher baseline negative affect but still did not predict affective cyclicity.ConclusionsAn individual's trait-like propensity to engage in rumination may not be a valid treatment target in premenstrual mood disorders. State-like changes in rumination should still be further explored, and well-powered prospective studies should explore other cognitive and behavioral factors to inform development of targeted psychological treatments for patients with cyclical affective symptoms.
Written corrective feedback in second language writing: A synthesis of naturalistic classroom studies
Authors: Mao Zhicheng , Lee Icy , Li Shaofeng 
Published: January 2024

Abstract
Written corrective feedback (WCF) is a ubiquitous pedagogical activity in second language (L2) classrooms and has become a key area of inquiry in L2 writing research. While there have been several reviews on experimental WCF research, there is not yet a synthesis of naturalistic classroom studies where the type and amount of feedback provided on students' writing performance is not manipulated or controlled. This state-of-the-art article intends to fill the gap by providing a comprehensive and critical review of naturalistic WCF studies in L2 writing, with significant implications for practice and research. A systematic search generated 50 empirical studies that met our inclusion criteria for the current review, which revealed four major themes: (1) teacher WCF practices in L2 writing classrooms, (2) L2 learner responses to WCF, (3) stakeholders’ beliefs and perspectives on WCF, and (4) WCF-related motivation and emotions. Based on the reviewed evidence, we propose pedagogical implications for enhancing teacher WCF practices and student learning, as well as potential avenues for further exploration. This article contributes to a nuanced understanding of current empirical advances in naturalistic research on WCF in L2 writing, providing insights to inform WCF pedagogy and new lines of inquiry.
Assemblage of forest communities in subtropical montane forests of western Mexico
Authors: Riaño Karolina , Cuevas Ramón , Zuloaga-Aguilar Susana , Jardel Enrique , Briones Oscar , Asbjornsen Heidi 
Published: January 2024

Abstract
Functional diversity indices have been used to differentiate the relative contribution of stochastic and deterministic processes that modulate the assemblage of communities; however, knowledge regarding the relative contribution of assemblage mechanisms in forest communities is scarce. We analysed the assembly mechanisms driving forest assemblages along a topographic gradient at two spatial scales (1000 m2 and 3000 m2) for three different forest types from subtropical mountain forests (pine-oak, mixed pine-broadleaf and broadleaf forest) in western Mexico, using null models of multi-trait indices. The forest structure differed along the topographic gradient. Upper slopes were dominated by Pinus douglasiana with an importance value index (IVI) of 0.8, while 10 and 13 tree species were required in the middle and lower slopes, respectively, to reach the same IVI. The results support the idea that the subtropical montane forest of western Mexico is a mosaic of communities, when analysed at a scale of 1000 m2 the forest assembly was mainly explained by stochastic processes, while analysis at the scale of 3000 m2 showed that functional convergence of species were the main mechanisms of the assemblage of the pine-oak forest communities due to an abiotic stressful environment.
The Resilient Youth Program: a promising skills-based online program for resiliency and stress management
Authors: Noyola Néstor , Ver Pault Mikayla , Hirshfeld-Becker Dina R. , Chudnofsky Rana , Meek Jocelyn , Wells Linda N. , Wilens Timothy E. , Henin Aude 
Published: January 2024

AbstractBackground:Prevention programs that target resilience may help youth address mental health difficulties and promote well-being during public health crises.Aims:To examine the preliminary efficacy of the Resilient Youth Program (RYP).Method:The RYP was delivered remotely from a US academic medical centre to youth in the community via a naturalistic pilot study. Data from 66 youth (ages 6–18, Mage = 11.65, SD = 3.02) and their parents were collected via quality assurance procedures (May 2020 to March 2021). Pre/post-intervention child/parent-reported psychological and stress symptoms as well as well-being measures were compared via Wilcoxon signed rank tests. Child/parent-reported skills use data were collected.Results:Among child-reported outcomes, there were significant decreases in physical stress (p = .03), anxiety (p = .004), depressive symptoms (p < .001) and anger (p = .002), as well as increased life satisfaction (p = .02). There were no significant differences in child-reported psychological stress (p = .06) or positive affect (p = .09). Among parent-reported child outcomes, there were significant decreases in psychological (p < .001) and physical stress (p = .03), anxiety (p < .001), depressive symptoms (p < .001), and anger (p < .002) as well as increased positive affect (p < .001) and life satisfaction (p < .001). Effect sizes ranged from small to medium; 77% of youth (73% of parents) reported using RYP skills. Age and gender were not associated with outcome change.Conclusions:The RYP may help reduce psychological/stress symptoms and increase well-being among youth; further research is needed.
Taxonomic resolution of fleabane species (Conyza spp.) based on morphological and molecular markers and their dispersion across soybean-cropping macroregions and seasons in Brazil
Authors: Kalsing Augusto , Nunes Felipe A. , Gotardi Guilherme A. , Campos Jaqueline B. , Schneider Angelo A. , Tropaldi Leandro , Velini Edivaldo D. , Merotto Aldo , Carbonari Caio A. 
Published: January 2024

AbstractThe Conyza genus includes nearly 150 species, comprising closely related weedy species. Proper identification of Conyza spp. is essential to develop effective strategies for their management. The overlap of traits, species varieties, and the putative occurrence of hybridization hampers the identification of Conyza spp. and its management in agricultural and natural environments. Herein, we assessed five DNA barcodes and 32 morphological traits to classify Conyza spp. and survey their dispersion in soybean fields [Glycine max (L.) Merr.] in Brazil in 2019, 2020, and 2021. The Conyza accessions included two species, hairy fleabane [Conyza bonariensis (L.) Cronquist) and Sumatran fleabane [Conyza sumatrensis (Retz.) E. Walker], and each species comprised two varieties. The ITS and rps16-trnQ gene regions showed the ability to distinguish between the two Conyza species, while the matK, rbcL, and trnF-trnF gene regions were not polymorphic. Out of 32 morphological traits, phyllary color, involucre shape, capitulescence type, and inflorescence type were the most polymorphic and even reliable for taxonomic purposes. The combination of ITS or ITS+rps16-trnQ regions and the four morphological markers was able to discriminate 91% of the plants, except those of C. bonariensis var. angustifolia. These results support the taxonomic resolution between C. bonariensis and C. sumatrensis and are useful for other Conyza spp. and other closely related weedy species worldwide. Conyza sumatrensis was detected in 94% of soybean fields across macroregions and seasons in Brazil, while C. bonariensis was sparsely dispersed, mainly in the southern macroregion (MRS 1).
“Seeing” Beneath the Clouds—Machine‐Learning‐Based Reconstruction of North African Dust Plumes
Authors: Kanngießer Franz , Fiedler Stephanie 
Published: January 2024

AbstractMineral dust is one of the most abundant atmospheric aerosol species and has various far‐reaching effects on the climate system and adverse impacts on air quality. Satellite observations can provide spatio‐temporal information on dust emission and transport pathways. However, satellite observations of dust plumes are frequently obscured by clouds. We use a method based on established, machine‐learning‐based image in‐painting techniques to restore the spatial extent of dust plumes for the first time. We train an artificial neural net (ANN) on modern reanalysis data paired with satellite‐derived cloud masks. The trained ANN is applied to cloud‐masked, gray‐scaled images, which were derived from false color images indicating elevated dust plumes in bright magenta. The images were obtained from the Spinning Enhanced Visible and Infrared Imager instrument onboard the Meteosat Second Generation satellite. We find up to 15% of summertime observations in West Africa and 10% of summertime observations in Nubia by satellite images miss dust plumes due to cloud cover. We use the new dust‐plume data to demonstrate a novel approach for validating spatial patterns of the operational forecasts provided by the World Meteorological Organization Dust Regional Center in Barcelona. The comparison elucidates often similar dust plume patterns in the forecasts and the satellite‐based reconstruction, but once trained, the reconstruction is computationally inexpensive. Our proposed reconstruction provides a new opportunity for validating dust aerosol transport in numerical weather models and Earth system models. It can be adapted to other aerosol species and trace gases.
Climate Change in the Thermosphere and Ionosphere From the Early Twentieth Century to Early Twenty‐First Century Simulated by the Whole Atmosphere Community Climate Model—eXtended
Authors: McInerney Joseph M. , Qian Liying , Liu Han‐Li , Solomon Stanley C. , Nossal Susan M. 
Published: January 2024

AbstractMotivated by numerous lower atmosphere climate model hindcast simulations, we performed simulations of the Earth's atmosphere from the surface up through the thermosphere‐ionosphere to reveal for the first time the century scale changes in the upper atmosphere from the 1920s through the 2010s using the Whole Atmosphere Community Climate Model—eXtended (WACCM‐X v. 2.1). We impose solar minimum conditions to get a clear indication of the effects of the long‐term forcing from greenhouse gas increases and changes of the Earth's magnetic field and to avoid the requirement for careful removal of the 11‐year solar cycle as in some previous studies using observations and models. These previous studies have shown greenhouse gas effects in the upper atmosphere but what has been missing is the time evolution with actual greenhouse gas increases throughout the last century, including the period of less than 5% increase prior to the space age and the transition to the over 25% increase in the latter half of the 20th century. Neutral temperature, density, and ionosphere changes are close to those reported in previous studies. Also, we find high correlation between the continuous carbon dioxide rate of change over this past century and that of temperature in the thermosphere and the ionosphere, attributed to the shorter adjustment time of the upper atmosphere to greenhouse gas changes relative to the longer time in the lower atmosphere. Consequently, WACCM‐X future scenario projections can provide valuable insight in the entire atmosphere of future greenhouse gas effects and mitigation efforts.
Steady Flow Over a Finite Patch of Submerged Flexible Vegetation
Authors: Kim Hyun Dong , Yu Xiao , Kaplan David 
Published: January 2024

AbstractAn immersed boundary‐finite element with soft‐body dynamics has been implemented to study steady flow over a finite patch of submerged flexible aquatic vegetation. The flow structure interaction model can resolve the flow interactions with flexible vegetation, and hence the reconfiguration of vegetation blades to ambient flow. Flow dynamics strongly depend on two dimensionless parameters, namely vegetation density and Cauchy number (defined as the ratio of the fluid drag force to the elastic force). Five different flow patterns have been identified based on vegetation density and Cauchy number, including the limited reach, swaying, “monami” A, “monami” B with slow moving interfacial wave, and prone. The “monami” B pattern occurred at high vegetation density and is different from “monami” A, in which the passage of Kelvin‐Helmholtz billows strongly affects the vegetation interface. With soft‐body dynamics, blade‐to‐blade interactions can also be resolved. At high vegetation density, the hydrodynamic interactions play an important role in blade‐to‐blade interactions, where adjacent vegetation blades interact via the interstitial fluid pressure. At low vegetation density, direct contacts among vegetation blades play important roles in preventing unphysical penetration of vegetation blades.
AURKA inhibition induces Ewing’s sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis
Authors: Chen Huimou , Hu Jing , Xiong Xilin , Chen Hongling , Lin Biaojun , Chen Yusong , Li Yang , Cheng Di , Li Zhihua 
Published: January 2024

AbstractEwing’s sarcoma (ES) is a rare and highly aggressive malignant tumor arising from bone and soft tissue. Suffering from intractable or recurrent diseases, the patients’ therapy options are very limited. It is extremely urgent to identify novel potential therapeutic targets for ES and put them into use in clinical settings. In the present study, high-throughput screening of a small molecular pharmacy library was performed. The killing effect of the Aurora kinase A (AURKA) inhibitor TCS7010 in ES cells was identified, and AURKA was selected as the research object for further study. Disparate suppressants were adopted to study the cell death manner of TCS7010. TCS7010 and RNA silencing were used to evaluate the functions of AURKA in the apoptosis and ferroptosis of ES cells. Co-immunoprecipitation assay was used to investigate the correlation of AURKA and nucleophosmin1 (NPM1) in ES. Nude-mice transplanted tumor model was used for investigating the role of AURKA in ES in vivo. Investigations into the protein activities of AURKA were conducted using ES cell lines and xenograft models. AURKA was found to be prominently upregulated in ES. The AURKA expression level was remarkably connected to ES patients’ shorter overall survival (OS) and event-free survival (EFS). Furthermore, AURKA inhibition markedly induced the apoptosis and ferroptosis of ES cells and attenuated tumorigenesis in vivo. On the part of potential mechanisms, it was found that AURKA inhibition triggered the apoptosis and ferroptosis of ES cells through the NPM1/Yes1 associated transcriptional regulator (YAP1) axis, which provides new insights into the tumorigenesis of ES. AURKA may be a prospective target for clinical intervention in ES patients.
Adaptive tactile interaction transfer via digitally embroidered smart gloves
Authors: Luo Yiyue , Liu Chao , Lee Young Joong , DelPreto Joseph , Wu Kui , Foshey Michael , Rus Daniela , Palacios Tomás , Li Yunzhu , Torralba Antonio , Matusik Wojciech 
Published: January 2024

AbstractHuman-machine interfaces for capturing, conveying, and sharing tactile information across time and space hold immense potential for healthcare, augmented and virtual reality, human-robot collaboration, and skill development. To realize this potential, such interfaces should be wearable, unobtrusive, and scalable regarding both resolution and body coverage. Taking a step towards this vision, we present a textile-based wearable human-machine interface with integrated tactile sensors and vibrotactile haptic actuators that are digitally designed and rapidly fabricated. We leverage a digital embroidery machine to seamlessly embed piezoresistive force sensors and arrays of vibrotactile actuators into textiles in a customizable, scalable, and modular manner. We use this process to create gloves that can record, reproduce, and transfer tactile interactions. User studies investigate how people perceive the sensations reproduced by our gloves with integrated vibrotactile haptic actuators. To improve the effectiveness of tactile interaction transfer, we develop a machine-learning pipeline that adaptively models how each individual user reacts to haptic sensations and then optimizes haptic feedback parameters. Our interface showcases adaptive tactile interaction transfer through the implementation of three end-to-end systems: alleviating tactile occlusion, guiding people to perform physical skills, and enabling responsive robot teleoperation.
Location-agnostic site-specific protein bioconjugation via Baylis Hillman adducts
Authors: Mir Mudassir H. , Parmar Sangeeta , Singh Chhaya , Kalia Dimpy 
Published: January 2024

AbstractProteins labelled site-specifically with small molecules are valuable assets for chemical biology and drug development. The unique reactivity profile of the 1,2-aminothiol moiety of N-terminal cysteines (N-Cys) of proteins renders it highly attractive for regioselective protein labelling. Herein, we report an ultrafast Z-selective reaction between isatin-derived Baylis Hillman adducts and 1,2-aminothiols to form a bis-heterocyclic scaffold, and employ it for stable protein bioconjugation under both in vitro and live-cell conditions. We refer to our protein bioconjugation technology as Baylis Hillman orchestrated protein aminothiol labelling (BHoPAL). Furthermore, we report a lipoic acid ligase-based technology for introducing the 1,2-aminothiol moiety at any desired site within proteins, rendering BHoPAL location-agnostic (not limited to N-Cys). By using this approach in tandem with BHoPAL, we generate dually labelled protein bioconjugates appended with different labels at two distinct specific sites on a single protein molecule. Taken together, the protein bioconjugation toolkit that we disclose herein will contribute towards the generation of both mono and multi-labelled protein-small molecule bioconjugates for applications as diverse as biophysical assays, cellular imaging, and the production of therapeutic protein–drug conjugates. In addition to protein bioconjugation, the bis-heterocyclic scaffold we report herein will find applications in synthetic and medicinal chemistry.
Two way workable microchanneled hydrogel suture to diagnose, treat and monitor the infarcted heart
Authors: Xue Fangchao , Zhao Shanlan , Tian Hao , Qin Haoxiang , Li Xiaochen , Jian Zhao , Du Jiahui , Li Yanzhao , Wang Yanhong , Lin Lin , Liu Chen , Shang Yongning , He Lang , Xing Malcolm , Zeng Wen 
Published: January 2024

AbstractDuring myocardial infarction, microcirculation disturbance in the ischemic area can cause necrosis and formation of fibrotic tissue, potentially leading to malignant arrhythmia and myocardial remodeling. Here, we report a microchanneled hydrogel suture for two-way signal communication, pumping drugs on demand, and cardiac repair. After myocardial infarction, our hydrogel suture monitors abnormal electrocardiogram through the mobile device and triggers nitric oxide on demand via the hydrogel sutures’ microchannels, thereby inhibiting inflammation, promoting microvascular remodeling, and improving the left ventricular ejection fraction in rats and minipigs by more than 60% and 50%, respectively. This work proposes a suture for bidirectional communication that acts as a cardio-patch to repair myocardial infarction, that remotely monitors the heart, and can deliver drugs on demand.
A strong fracture-resistant high-entropy alloy with nano-bridged honeycomb microstructure intrinsically toughened by 3D-printing
Authors: Kumar Punit , Huang Sheng , Cook David H. , Chen Kai , Ramamurty Upadrasta , Tan Xipeng , Ritchie Robert O. 
Published: January 2024

AbstractStrengthening materials via conventional “top-down” processes generally involves restricting dislocation movement by precipitation or grain refinement, which invariably restricts the movement of dislocations away from, or towards, a crack tip, thereby severely compromising their fracture resistance. In the present study, a high-entropy alloy Al0.5CrCoFeNi is produced by the laser powder-bed fusion process, a “bottom-up” additive manufacturing process similar to how nature builds structures, with the microstructure resembling a nano-bridged honeycomb structure consisting of a face-centered cubic (fcc) matrix and an interwoven hexagonal net of an ordered body-centered cubic B2 phase. While the B2 phase, combined with high-dislocation density and solid-solution strengthening, provides strength to the material, the nano-bridges of dislocations connecting the fcc cells, i.e., the channels between the B2 phase on the cell boundaries, provide highways for dislocation movement away from the crack tip. Consequently, the nature-inspired microstructure imparts the material with an excellent combination of strength and toughness.
PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury
Authors: Du Xinyue , Ren Baiyang , Li Chang , Li Qi , Kan Shuo , Wang Xin , Bai Wenjuan , Wu Chenyun , Kassegne Kokouvi , Yan Huibo , Niu Xiaoyin , Yan Min , Xu Wenyue , Wassmer Samuel C. , Wang Jing , Chen Guangjie , Wang Zhaojun 
Published: January 2024

AbstractExcessive host immune responses contribute to severe malaria with high mortality. Here, we show that PRL2 in innate immune cells is highly related to experimental malaria disease progression, especially the development of murine severe malaria. In the absence of PRL2 in myeloid cells, Plasmodium berghei infection results in augmented lung injury, leading to significantly increased mortality. Intravital imaging revealed greater neutrophilic inflammation and NET formation in the lungs of PRL2 myeloid conditional knockout mice. Depletion of neutrophils prior to the onset of severe disease protected mice from NETs associated lung injury, and eliminated the difference between WT and PRL2 CKO mice. PRL2 regulates neutrophil activation and NET accumulation via the Rac-ROS pathway, thus contributing to NETs associated ALI. Hydroxychloroquine, an inhibitor of PRL2 degradation alleviates NETs associated tissue damage in vivo. Our findings suggest that PRL2 serves as an indicator of progression to severe malaria and ALI. In addition, our study indicated the importance of PRL2 in NET formation and tissue injury. It might open a promising path for adjunctive treatment of NET-associated disease.