bluuebunny/crossref_metadata_2025_split huggingface dataset:
Son of Enron: Investors Weigh the Risks of Chinese Variable Interest Entities
Authors: Gillis Paul , Lowry Michelle René 
Published: October 2023

Investors are heading back to China after ending a buyers' strike in response to numerous accounting scandals and corporate governance failures. There have been several successful IPOs in recent months, and the market is awaiting the listing of the internet giant The Alibaba Group.The Alibaba IPO has focused investor attention on the use of the variable interest entity (or VIE) structure by other overseas listed Chinese companies as well as Alibaba. The VIE structure allows outside investors some measure of influence or control over Chinese operations that is exercised through contracts instead of actual equity ownership. By using such contracts, companies are able to circumvent Chinese laws that severely restrict ownership in many industries, including the internet sector.The contracts attempt to replicate the benefits of direct ownership, but do so imperfectly. The biggest concern over the VIE structure is the enforceability of the contracts. China has a law that invalidates contracts that attempt to do what is illegal through legal means. One court case involving a VIE‐like structure led China's Supreme Court to rule that the contracts were unenforceable, and arbitrators reached the same decision.The biggest nightmare of investors in Chinese VIE structures is that the Chinese owner of the operating company could choose to abrogate the contracts and take ownership of the VIE. The highest profile example of this took place in 2011, when Alipay faced increased regulatory scrutiny and Jack Ma responded by extracting it from the Alibaba Group.The fix for China's VIE problem has to come from Chinese regulators, and reforms to foreign investment rules that have been proposed may make the VIE structure obsolete. But until then, investors have to weigh the unusual risk of investing in companies that they do not own.
The State of the Public Corporation: Not So Much an Eclipse as an Evolution
Authors: Ciccotello Conrad S. 
Published: October 2023

By some measures, the U.S. public corporation appears to be in the midst of a significant decline, as Michael Jensen predicted 25 years ago in a Harvard Business Review article called “The Eclipse of the Public Corporation.” Based on an analysis of ten industries during the 48‐year period from 1966 through the end of 2013, the author reports a 60% drop in the number of publicly traded U.S. companies, as measured from each of the industry peaks to the end of 2013. Mergers and acquisitions, together with the private‐equity transactions hailed by Jensen in his 1989 HBR article, have contributed significantly to this reduction in numbers. But so has the remarkable growth of “uncorporate” (or pass‐through) structures such as Master Limited Partnerships (MLPs) and Real Estate Investment Trusts (REITs), both of which address governance as well as tax problems faced by public C‐corporations.But along with this drop in numbers, the author's analysis of the performance of U.S. public companies—as measured both by operating returns on equity and Tobin's Q ratios—also shows a growing separation of the “best” from the “rest” over time. Intense global product market competition, the growing benefits (and urgency) of achieving efficient scope and scale, high U.S. corporate income tax rates, and a vigorous market for corporate control are all significantly “thinning the herd” of public corporations. The “winners” have been emerging as larger, more efficient, and more influential enterprises than ever before, as the rise of massive U.S. multinationals (and, in countries outside the U.S., state‐owned enterprises) over the past two decades has increasingly blurred the line between private business and government.Viewed in this light, the overall trends, both in the U.S. and abroad, suggest an evolution rather than an eclipse of the public corporation. Such trends also suggest that over the next 25 years, the success of the public corporation will increasingly depend on issues such as its ability to resolve conflicts between controlling shareholders (including sovereign governments) and minority shareholders, regulatory (in particular, antitrust) policy, and the role (and investment horizons) of activist shareholders.
Morphological features of the greater occipital nerve and its possible importance for interventional procedures
Authors: Saglam Latif , Gayretli Ozcan , Coskun Osman , Kale Aysin 
Published: October 2023

AbstractBeing one of the most prevalent neurological symptoms, headaches are burdensome and costly. Blocks and decompression surgeries of the greater occipital nerve (GON) have been frequently used for migraine, cervicogenic headache, and occipital neuralgia which are classified under headache by International Headache Society. Knowledge of complex anatomy of GON is crucial for its decompression surgery and block. This study was performed to elucidate anatomical features of this nerve in detail. Forty‐one cadavers were dissected bilaterally. According to its morphological features, GON was classified into four main types that included 18 subtypes. Moreover, potential compression points of the nerve were defined. The number of branches of the GON up to semispinalis capitis muscle and the number of its branches that were sent to this muscle were recorded. The most common variant was that the GON pierced the aponeurosis of the trapezius muscle, curved around the lower edge of the obliquus capitis inferior muscle, and was loosely attached to the obliquus capitis inferior muscle (Type 2; 61 sides, 74.4%). In the subtypes, the most common form was Type 2‐A (44 sides, 53.6%), in which the GON pierced the aponeurosis of each of the trapezius muscle and fibers of semispinalis muscle at one point and there was a single crossing of the GON and occipital artery. Six potential compression points of the GON were detected. The first point was where the nerve crossed the lower border of the obliquus capitis inferior muscle. The second and third points were at its piercing of the semispinalis capitis muscle and the muscle fibers/aponeurosis of the trapezius, respectively. Fourth, fifth, and sixth compression points of GON were located where the GON and occipital artery crossed each other for the first, second, and third times, respectively. On 69 sides, 1–4 branches of the GON up to the semispinalis capitis muscle were observed (median = 1), while 1–4 branches of GON were sent to the semispinalis capitis muscle on 67 sides (median = 1). The novel anatomical findings described in this study may play a significant role in increasing the success rate of invasive interventions related with the GON.
Boundless Partnership: 19th‐Century Literature and Dance
Authors: Wilson Cheryl A. 
Published: October 2023

AbstractDancing bodies and scenes of dance appear throughout the 19th‐century literature. Bringing the dance historical perspective to literary studies helps to situate texts within important social and cultural contexts and also raises questions about the presence of moving bodies within texts and how those bodies might have been deployed by the 19th‐century writers. Recently, scholars have attempted to bridge the gap between dancing bodies and textual bodies by bringing dance history and criticism into conversation with the article of the 19th‐century literary texts, creating the field of dance and literature studies. This field has rich potential for interdisciplinary studies and also much to offer both literary studies and dance history.
Shakespeare and History Writing
Authors: Breen Dan 
Published: October 2023

AbstractThis article addresses recent developments in literary‐critical studies of Shakespeare's status within the wider field of early modern historiography. Since the advent of new historicist criticism, Shakespeare's plays have been read with increasing regularity as contributing to a broader early modern historical culture, in which writers of traditionally “literary” and traditionally “historiographical” texts alike considered questions of politics, philosophy, and religion. Complementing this opening up of the category of historical writing is a similarly expanding sense of what it is that might be considered a “history play.” Along with the plays dramatizing medieval English history, scholars have begun to examine the Roman tragedies and the late plays addressing the legendary history of Britain for their contributions to cultural discourses of nationalism, sovereignty, citizenship, and identity. In addition, performance studies criticism has challenged the field to consider theatrical performance itself as a discrete and heretofore overlooked mode of historical representation, while attention to the historiographical status of material objects has shed light on the different ways in which non‐textual artifacts can both shape and produce multiple aspects of cultural history. Further work with specifically early modern conceptions of material history and renewed and deliberate efforts to open the field of literary and theatrical studies to scholars in other fields promise to add a great deal to this newly emerging version of a historiographically engaged Shakespeare, who appears in many ways to exhibit more strikingly humanist sympathies than scholars have acknowledged during the last several decades.
Inferring the distribution of norovirus in individual oysters below the limit of quantification by pooled sampling
Authors: Wang Jianxin , Zhou Chen , Wang Yeru 
Published: October 2023

AbstractNorovirus (NoV) in oysters is a food safety risk of much concern. In order to assess the risk of the exposure, the distribution of the number of NoV copies contained in each oyster should be acquired first for comprehensively quantifying the associated risks. However, the part of the distribution below the limit of quantification cannot be obtained directly by laboratory detecting methods, which hampers accurate assessment. To tackle this challenging problem, a systematic method (Distribution Inference Method by Pooled Sampling) is proposed to infer the unobservable part of distribution based upon all measurements of the pooled samples with n = 2. Using convolutional integrals and real‐coded genetic algorithm for inferring, this method has neither requirements for the type or properties of the original distribution, nor requirements for historical data, even nor requirements for the relationship between observable and unobservable parts of the distribution. A series of experiments were conducted on simulated datasets of a variety of types, including normal distribution, uniform distribution, gamma distribution, lognormal distribution, zero‐inflated Poisson distribution, their combinations, and even their splicing, covering common distribution types in oyster NoV scenario and more general scenarios. The results show that almost all inferred simulation data and their original counterparts passed Kolmogorov–Smirnov tests, which implies that they are essential of the same distribution. Based on this method, a ready‐to‐use web system was developed for researchers to infer their original distribution with pooled‐sampling measurements from the detection of NoV or even other substances.
Leading the pack: Best practices in comparative canine cancer genomics to inform human oncology
Authors: London Cheryl A. , Gardner Heather , Zhao Shaying , Knapp Deborah W. , Utturkar Sagar M. , Duval Dawn L. , Chambers Melissa R. , Ostrander Elaine , Trent Jeffrey M. , Kuffel Gina 
Published: October 2023

AbstractPet dogs develop spontaneous cancers at a rate estimated to be five times higher than that of humans, providing a unique opportunity to study disease biology and evaluate novel therapeutic strategies in a model system that possesses an intact immune system and mirrors key aspects of human cancer biology. Despite decades of interest, effective utilization of pet dog cancers has been hindered by a limited repertoire of necessary cellular and molecular reagents for both in vitro and in vivo studies, as well as a dearth of information regarding the genomic landscape of these cancers. Recently, many of these critical gaps have been addressed through the generation of a highly annotated canine reference genome, the creation of several tools necessary for multi‐omic analysis of canine tumours, and the development of a centralized repository for key genomic and associated clinical information from canine cancer patients, the Integrated Canine Data Commons. Together, these advances have catalysed multidisciplinary efforts designed to integrate the study of pet dog cancers more effectively into the translational continuum, with the ultimate goal of improving human outcomes. The current review summarizes this recent progress and provides a guide to resources and tools available for comparative study of pet dog cancers.
Tomography of Detectors Taking Dead Time into Account
Authors: Bogdanov Yu. I. , Katamadze K. G. , Borshchevskaya N. A. , Avosopiants G. V. , Bogdanova N. A. , Kulik S. P. , Lukichev V. F. 
Published: October 2023

Abstract
Using numerical simulation methods that take into account the dead time effect, algorithms are developed to calculate the detector’s response for photon fluxes with different photon number distributions, including the Poisson, Fock, and thermal distributions. Based on the results obtained, a detector tomography method is developed, as well as an algorithm for identifying the corresponding elements of a positive operator-valued measure (POVM). Experimental studies using coherent states demonstrate close agreement between the calculation results and experimental data.
Private pharmacies as healthcare providers in Odisha, India: analysis and implications for universal health coverage
Authors: Kalita Anuska , Bose Bijetri , Woskie Liana , Haakenstad Annie , Cooper Jan E , Yip Winnie 
Published: October 2023

IntroductionIn India, as in many low-income and middle-income countries, the private sector provides a large share of health care. Pharmacies represent a major share of private care, yet there are few studies on their role as healthcare providers. Our study examines: (1) What are the characteristics of and services provided by private pharmacies and how do these compare with other outpatient care providers? (2) What are the characteristics of patients who opted to use private pharmacies? (3) What are the reasons why people seek healthcare from private pharmacies? (4) What are the quality of services and cost of care for these patients? Based on our findings, we discuss some policy implications for universal health coverage in the Indian context.MethodsWe analyse data from four surveys in Odisha, one of India’s poorest states: a household survey on health-seeking behaviours and reasons for healthcare choices (N=7567), a survey of private pharmacies (N=1021), a survey of public sector primary care facilities (N=358), and a survey of private-sector solo-providers (N=684).Results17% of the households seek outpatient care from private pharmacies (similar to rates for public primary-care facilities). 25% of the pharmacies were not registered appropriately under Indian regulations, 90% reported providing medical advice, and 26% reported substituting prescribed drugs. Private pharmacies had longer staffed hours and better stocks of essential drugs than public primary-care facilities. Patients reported choosing private pharmacies because of convenience and better drug stocks; reported higher satisfaction and lower out-of-pocket expenditure with private pharmacies than with other providers.ConclusionThis is the first large-scale study of private pharmacies in India, with a comparison to other healthcare providers and users’ perceptions and experiences of their services. To move towards universal health coverage, India, a country with a pluralistic health system, needs a comprehensive health systems approach that incorporates both the public and private sectors, including private pharmacies.
Generalized models for black-bounce solutions in f(R) gravity
Authors: Fabris Júlio C. , Junior Ednaldo L. B. , Rodrigues Manuel E. 
Published: October 2023

AbstractIn this article, the implementation of black-bounce solutions in f(R) theories is investigated. Black-bounce solutions are regular configurations of the static spherically symmetric space-time, containing both black holes and wormholes structures. In General Relativity (GR), black-bounce solution implies violation of the energy conditions. We investigate the same issue in f(R) theories using two strategies: first, supposing a given form for the f(R) function and then determining the matter behavior; second, imposing a condition on the matter density and obtaining the resulting f(R) function. In all cases, a given structure for the metric functions is supposed. Violation of the energy conditions still occur but they are less severe than in the corresponding GR cases. We propose a zero-density model that has horizons, which differs from the GR case. We also propose a model with positive energy density and show that $$\rho +p_r>0$$

ρ
+

p
r

>
0

, which was not the case in GR.
Exposures to humidifier disinfectant and various health conditions in Korean based on personal exposure assessment data of claimants for compensation
Authors: Hong Myeongjin , Ju Min Jae , Yoon Jeonggyo , Lee Wonyoung , Lee Seula , Jo Eun-kyung , Choi Seo-Youn , Yang Wonho , Choi Yoon-Hyeong 
Published: October 2023

Abstract
Background
Humidifier disinfectants (HDs) were commonly used household chemicals to prevent microbial growth in a humidifier water tank in South Korea. A growing body of evidence has indicated that its airborne exposure can induce severe lung injury. However, there has been low awareness of other health outcomes in HD users. This study aimed to evaluate health conditions appealed by claimants for compensation in relation with an increased exposure to HD.

Methods
From survey data of personal HD exposure assessment of claimants for compensation in Korea, we included a total of 4,179 subjects [cases in each dataset were defined by nine reported health conditions, i.e., pneumonia, asthma, cardiovascular disease, respiratory disease, otorhinolaryngologic disease, brain disease (including cerebrovascular disease), dermatological disease, lung cancer, and all cancers]. HD exposures was considered as the following exposure criteria: exposure duration, exposure proximity, exposure direction, chemical type, cumulative exposure time, indoor air concentration, and cumulative exposure level. Logistic regression models were used to evaluate the associations between HD exposure and health conditions.

Results
After adjusting for sociodemographic and health behavioral factors and other chemical exposures (households, environmental, and occupational exposures), an increase in cumulative HD exposure time was significantly associated with risks of all nine diseases (all p-trends < 0.05). An increase in HD exposure duration was associated with asthma, respiratory disease, otorhinolaryngologic disease, dermatological disease, all cancers, and lung cancer (p-trends < 0.05). Indoor HD concentration was associated with only pneumonia (p-trend = 0.015).

Conclusions
Our findings suggest that cumulative exposures to airborne HD might potentially increase the risk of various reported health outcomes.
PCIF1, the only methyltransferase of N6,2-O-dimethyladenosine
Authors: Wu Yuting , Pu Xi , Wu Sihui , Zhang Yiran , Fu Shengqiao , Tang Haowen , Wang Xu , Xu Min 
Published: October 2023

AbstractN6-methyladenosine(m6A), is the most abundant post-transcriptional modification of mRNA in biology. When the first nucleotide after the m7G cap is adenosine, it is methylated at the N6 position to form N6,2-O-dimethyladenosine (m6Am). m6Am is a reversible modification located at the first transcribed nucleotide, which is present in about 30% of cellular mRNAs, thus m6Am can have a significant impact on gene expression in the transcriptome. Phosphorylated CTD interaction factor 1(PCIF1), the unique and specific methyltransferase of m6Am, has been shown to affect mRNA stability, transcription, and translation. Several studies have shown that PCIF1 is clearly associated with tumor, viral, and endocrine diseases. Moreover, PCIF1 may be related to the tumor microenvironment, immune cell typing, and programmed cell death protein 1(PD-1) drug resistance. Here, we summarize the mechanism of PCIF1 involvement in mRNA modifications, and outline m6Am modifications and diseases in which PCIF1 is involved. We also summarized the role of PCIF1 in immune and immune checkpoint blockade(ICB) treatment, and predicted the possibility of PCIF1 as a biomarker and therapeutic target.
Tyrosine kinase signaling-independent MET-targeting with CAR-T cells
Authors: Qin Anna , Qin Yuan , Lee Joseph , Musket Anna , Ying Mingyao , Krenciute Giedre , Marincola Francesco M. , Yao Zhi Q. , Musich Phillip R. , Xie Qian 
Published: October 2023

Abstract
Background
Recent progress in cancer immunotherapy encourages the expansion of chimeric antigen receptor (CAR) T cell therapy in solid tumors including hepatocellular carcinoma (HCC). Overexpression of MET receptor tyrosine kinase is common in HCC; however, MET inhibitors are effective only when MET is in an active form, making patient stratification difficult. Specific MET-targeting CAR-T cells hold the promise of targeting HCC with MET overexpression regardless of signaling pathway activity.

Methods
MET-specific CARs with CD28ζ or 4-1BBζ as co-stimulation domains were constructed. MET-CAR-T cells derived from healthy subjects (HS) and HCC patients were evaluated for their killing activity and cytokine release against HCC cells with various MET activations in vitro, and for their tumor growth inhibition in orthotopic xenograft models in vivo.

Results
MET-CAR.CD28ζ and MET-CAR.4-1BBζ T cells derived from both HS and HCC patients specifically killed MET-positive HCC cells. When stimulated with MET-positive HCC cells in vitro, MET-CAR.CD28ζ T cells demonstrated a higher level of cytokine release and expression of programmed cell death protein 1 (PD-1) than MET-CAR.4-1BBζ T cells. When analyzed in vivo, MET-CAR.CD28ζ T cells more effectively inhibited HCC orthotopic tumor growth in mice when compared to MET-CAR.4-1BBζ T cells.

Conclusion
We generated and characterized MET-specific CAR-T cells for targeting HCC with MET overexpression regardless of MET activation. Compared with MET-CAR.4-1BBζ, MET-CAR.CD28ζ T cells showed a higher anti-HCC potency but also a higher level of T cell exhaustion. While MET-CAR.CD28ζ is preferred for further development, overcoming the exhaustion of MET-CAR-T cells is necessary to improve their therapeutic efficacy in vivo.
Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis
Authors: Zhang Dingkun , Deng Xuan , Li Mengqi , Qiu Min , Zhang Yifan , Li Gefei , Jiang Yurou , Tan Peng , Fan Sanhu , Zheng Youde , Lin Junzhi , Han Li , Huang Haozhou 
Published: October 2023

AbstractPolyphenols are the main component of Phyllanthus emblica (PE). However, polyphenols are so easy to transform that it is unknown that how drying methods driven by heating affect the anti-fatigue effect of PE. This manuscript investigated the effects of five drying methods on the chemical composition transformation and anti-fatigue of PE, and discussed the action mechanism. The results suggested that the anti-fatigue effect of PE with hot-air-dried at 100 °C was the best, which was as 1.63 times as that with freeze-drying. Ellagic acid (EA) may be a key component of PE in anti-fatigue, and its mechanism of action may be related to regulating intestinal microbiota, protecting mitochondria, and regulating energy metabolism. This study first revealed the thermal transformation of polyphenols in PE, found the most effective strategy for enhancing the anti-fatigue function, and explores its action mechanism.