bluuebunny/crossref_metadata_2025_split huggingface dataset:
The UK prosthetic and orthotic workforce: current status and implications for the future
Authors: Eddison Nicola , Healy Aoife , Leone Enza , Jackson Caroline , Pluckrose Bracken , Chockalingam Nachiappan 
Published: January 2024

Abstract
Background
Prosthetists and orthotists (POs) are the smallest of the 14 allied health profession (AHP) workforces within NHS England. Obtaining data on the workforce has always been challenging due to this information being held across different organisations. An understanding of the prosthetic and orthotic (P&O) workforce is essential to ensure that it is adequately equipped to meet the evolving needs of users of P&O services. The study aims to estimate the size and composition, for the first time, of the UK P&O workforce and P&O service provision.

Methods
To gather the required information, two surveys (one for the UK P&O workforce and one for UK P&O private company) and two freedom of information (FOI) requests [one for all NHS Trusts and Health Boards (HB) in the UK and one for the higher education institutes in the UK offering programmes leading to registration as a PO were developed and distributed from September to December 2022.

Results
The P&O workforce survey received a 74% response rate (863 POs) and 25 private companies reported employing one or more P&O staffing groups. From the FOI requests, 181 of a potential 194 Trusts/Health Boards and all four higher education institutions responded. The study indicated a total of 1766 people in the UK P&O workforce, with orthotists and orthotic technicians representing the largest percentage of the workforce at 32% and 30%, respectively. A greater percentage of prosthetists (65%) and orthotists (57%) were employed by private companies compared to the NHS. Only 34% of POs stated that they “definitely” planned to remain in the workforce for the next 5 years. The current UK PO employment levels are 142 to 477 short of the World Health Organisation’s (WHO) recommendation.

Conclusions
The low job satisfaction amongst many POs and the projected increase in the number of people who will require prosthetic and/or orthotic care in the UK are challenges for future UK P&O services. Strategies are required to create a sustainable and resilient workforce that can meet the needs of a changing healthcare landscape.
Total and temporal patterning of physical activity in adolescents and associations with mental wellbeing
Authors: Alshallal Abdulwahab D. , Alliott Olivia , Brage Soren , van Sluijs Esther M. F. , Wilkinson Paul , Corder Kirsten , Winpenny Eleanor M. 
Published: January 2024

Abstract
Background
There is limited understanding of the extent to which differences in physical activity across the day and week may be associated with mental wellbeing. Such an understanding is needed for better targeting of interventions. In this study, we describe total and temporal patterning of physical activity across the week in adolescents (age 13-14y) and assess their prospective associations with mental wellbeing.

Methods
1,983 13-14-year-old adolescent participants based in Cambridgeshire and Essex, recruited between 2016 and 2017 into the Get Others Active Trial provided data at baseline and 4 months. Physical activity was measured at baseline using wrist-worn accelerometers across different time segments (whole week, weekday schooltime, weekday out of school, and weekend), and operationalized as average movement-related acceleration for each time segment. Mental Wellbeing at baseline and 4 months was measured using the Warwick Edinburgh MentalWellbeing Scale. Associations between physical activity across different time segments (whole week, weekday schooltime, weekday out of school, and weekend) and mental wellbeing at 4 months were investigated using sex-stratified multi-level regression models, adjusted for covariates, and both adjusted and unadjusted for baseline mental wellbeing.

Results
Our analyses found positive associations between physical activity and mental wellbeing at 4 months, unadjusted for baseline wellbeing. Among girls, positive associations were shown when considering physical activity across the whole week 0.07 (95% CI, 0.03–0.12), and across all separate time periods studied: weekday schooltime 0.07 (95% CI, 0.02–0.11), weekday out-of-school time 0.07 (95% CI, 0.03–0.12), and weekend 0.07 (95% CI, 0.02–0.11). For boys, similar associations were observed for activity across the week 0.07 (95% CI, 0.03–0.11), during weekday schooltime 0.08 (95% CI, 0.04–0.12), and weekday out-of-school time 0.07 (95% CI, 0.03–0.11), but not the weekend 0.01 (95% CI, -0.03-0.05). For both girls and boys, associations were attenuated below significance after adjusting for baseline wellbeing.

Conclusions
This longitudinal analysis showed positive associations between physical activity and later mental wellbeing in both male and female adolescents across most time segments. Higher physical activity throughout the week may be associated with better mental wellbeing in the adolescent population. Further research is required to understand determinants of change in wellbeing over time.

Trial Registration
Registration Number: ISRCTN31583496. Registered: 18/02/2014.
A regional genomic surveillance program is implemented to monitor the occurrence and emergence of SARS-CoV-2 variants in Yubei District, China
Authors: Liu Fangyuan , Deng Peng , He Jiuhong , Chen Xiaofeng , Jiang Xinyu , Yan Qi , Xu Jing , Hu Sihan , Yan Jin 
Published: January 2024

Abstract
Background
In December 2022, Chongqing experienced a significant surge in coronavirus disease 2019 (COVID-19) epidemic after adjusting control measures in China. Given the widespread immunization of the population with the BA.5 variant, it is crucial to actively monitor severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant evolution in Chongqing's Yubei district.

Methods
In this retrospective study based on whole genome sequencing, we collected oropharyngeal and nasal swab of native COVID-19 cases from Yubei district between January to May 2023, along with imported cases from January 2022 to January 2023. Through second-generation sequencing, we generated a total of 578 genomes.

Results
Phylogenetic analyses revealed these genomes belong to 47 SARS-CoV-2 Pango lineages. BA.5.2.48 was dominant from January to April 2023, rapidly replaced by XBB* variants from April to May 2023. Bayesian Skyline Plot reconstructions indicated a higher evolutionary rate (6.973 × 10–4 subs/site/year) for the XBB.1.5* lineage compared to others. The mean time to the most recent common ancestor (tMRCA) of BA.5.2.48* closely matched BA.2.75* (May 27, 2022). Using multinomial logistic regression, we estimated growth advantages, with XBB.1.9.1 showing the highest growth advantage (1.2, 95% HPI:1.1–1.2), followed by lineage FR.1 (1.1, 95% HPI:1.1–1.2).

Conclusions
Our monitoring reveals the rapid replacement of the previously prevalent BA.5.2.48 variant by XBB and its sub-variants, underscoring the ineffectiveness of herd immunity and breakthrough BA.5 infections against XBB variants. Given the ongoing evolutionary pressure, sustaining a SARS-CoV-2 genomic surveillance program is imperative.
Metabolic alterations in urine among the patients with severe fever with thrombocytopenia syndrome
Authors: Zhang Shan-Shan , Yang Xin , Zhang Wan-Xue , Zhou Yiguo , Wei Ting-Ting , Cui Ning , Du Juan , Liu Wei , Lu Qing-Bin 
Published: January 2024

Abstract
Background
The pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) remained unclear. We aimed to profile the metabolic alterations in urine of SFTS patients and provide new evidence for its pathogenesis.

Methods
A case–control study was conducted in the 154th hospital in China. Totally 88 cases and 22 controls aged ≥ 18 years were enrolled. The cases were selected from laboratory-confirmed SFTS patients. The controls were selected among SFTSV-negative population. Those with diabetes, cancer, hepatitis and other sexually transmitted diseases were excluded in both groups. Fatal cases and survival cases were 1:1 matched. Inter-group differential metabolites and pathways were obtained, and the inter-group discrimination ability was evaluated.

Results
Tryptophan metabolism and phenylalanine metabolism were the top one important metabolism pathway in differentiating the control and case groups, and the survival and fatal groups, respectively. The significant increase of differential metabolites in tryptophan metabolism, including 5-hydroxyindoleacetate (5-HIAA), L-kynurenine (KYN), 5-hydroxy-L-tryptophan (5-HTP), 3-hydroxyanthranilic acid (3-HAA), and the increase of phenylpyruvic acid and decrease of hippuric acid in phenylalanine metabolism indicated the potential metabolic alterations in SFTSV infection. The increase of 5-HIAA, KYN, 5-HTP, phenylpyruvic acid and hippuric acid were involved in the fatal progress of SFTS patients.

Conclusions
Tryptophan metabolism and phenylalanine metabolism might be involved in the pathogenesis of SFTSV infection. These findings provided new evidence for the pathogenesis and treatment of SFTS.
Postnatal meningeal CSF transport is primarily mediated by the arachnoid and pia maters and is not altered after intraventricular hemorrhage-posthemorrhagic hydrocephalus
Authors: Pan Shelei , Koleske Joshua P. , Koller Gretchen M. , Halupnik Grace L. , Alli Abdul-Haq O. , Koneru Shriya , DeFreitas Dakota , Ramagiri Sruthi , Strahle Jennifer M. 
Published: January 2024

Abstract
Background
CSF has long been accepted to circulate throughout the subarachnoid space, which lies between the arachnoid and pia maters of the meninges. How the CSF interacts with the cellular components of the developing postnatal meninges including the dura, arachnoid, and pia of both the meninges at the surface of the brain and the intracranial meninges, prior to its eventual efflux from the cranium and spine, is less understood. Here, we characterize small and large CSF solute distribution patterns along the intracranial and surface meninges in neonatal rodents and compare our findings to meningeal CSF solute distribution in a rodent model of intraventricular hemorrhage-posthemorrhagic hydrocephalus. We also examine CSF solute interactions with the tela choroidea and its pial invaginations into the choroid plexuses of the lateral, third, and fourth ventricles.

Methods
1.9-nm gold nanoparticles, 15-nm gold nanoparticles, or 3 kDa Red Dextran Tetramethylrhodamine constituted in aCSF were infused into the right lateral ventricle of P7 rats to track CSF circulation. 10 min post-1.9-nm gold nanoparticle and Red Dextran Tetramethylrhodamine injection and 4 h post-15-nm gold nanoparticle injection, animals were sacrificed and brains harvested for histologic analysis to identify CSF tracer localization in the cranial and spine meninges and choroid plexus. Spinal dura and leptomeninges (arachnoid and pia) wholemounts were also evaluated.

Results
There was significantly less CSF tracer distribution in the dura compared to the arachnoid and pia maters in neonatal rodents. Both small and large CSF tracers were transported intracranially to the arachnoid and pia mater of the perimesencephalic cisterns and tela choroidea, but not the falx cerebri. CSF tracers followed a similar distribution pattern in the spinal meninges. In the choroid plexus, there was large CSF tracer distribution in the apical surface of epithelial cells, and small CSF tracer along the basolateral surface. There were no significant differences in tracer intensity in the intracranial meninges of control vs. intraventricular hemorrhage-posthemorrhagic hydrocephalus (PHH) rodents, indicating preserved meningeal transport in the setting of PHH.

Conclusions
Differential CSF tracer handling by the meninges suggests that there are distinct roles for CSF handling between the arachnoid-pia and dura maters in the developing brain. Similarly, differences in apical vs. luminal choroid plexus CSF handling may provide insight into particle-size dependent CSF transport at the CSF-choroid plexus border.
Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine-coupled pyrazole derivatives
Authors: Berhe Halefom Gebreselasse , Birhan Yihenew Simegniew , Beshay Botros Youssef , Habib Huda Jawad , Hymete Ariaya , Bekhit Adnan Ahmed 
Published: January 2024

AbstractPyrazole-bearing compounds are known for their diverse pharmacological effects including potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled pyrazoles were successfully synthesized and their structures were verified by employing elemental microanalysis, FTIR, and 1H NMR techniques. The in vitro antileishmanial and in vivo antimalarial activities of the synthesized pyrazole derivatives (9–15) were evaluated against Leishmania aethiopica clinical isolate and Plasmodium berghei infected mice, respectively. The result revealed that compound 13 displayed superior antipromastigote activity (IC50 = 0.018) that was 174- and 2.6-fold more active than the standard drugs miltefosine (IC50 = 3.130) and amphotericin B deoxycholate (IC50 = 0.047). The molecular docking study conducted on Lm-PTR1, complexed with Trimethoprim was acquired from the Protein Data Bank (PDB ID:2bfm), justified the better antileishmanial activity of compound 13. Furthermore, the target compounds 14 and 15 elicited better inhibition effects against Plasmodium berghei with 70.2% and 90.4% suppression, respectively. In conclusion, the hydrazine-coupled pyrazole derivatives may be considered potential pharmacophores for the preparation of safe and effective antileishmanial and antimalarial agents.
Clinical and non-contrast computed tomography characteristics and disease development in patients with benign pulmonary subsolid nodules with a solid component ≤ 5 mm
Authors: Wu Shun , Fan Xiao , Li Xian , Luo Tian-you , Li Xing-hua , Li Qi 
Published: January 2024

Abstract
Objectives
To evaluate the clinical and non-contrast computed tomography (CT) features of patients with benign pulmonary subsolid nodules (SSNs) with a solid component ≤ 5 mm and their development trends via follow-up CT.

Methods
We retrospectively collected 436 data from patients who had SSNs with a solid component ≤ 5 mm, including 69 with absorbable benign SSNs (AB-SSNs), 70 with nonabsorbable benign SSNs (NB-SSNs), and 297 with malignant SSNs (M-SSNs). Models 1, 2, and 3 for distinguishing the different types of SSNs were then developed and validated.

Results
Patients with AB-SSNs were younger and exhibited respiratory symptoms more frequently than those with M-SSNs. The frequency of nodules detected during follow-up CT was in the following order: AB-SSNs > NB-SSNs > M-SSNs. NB-SSNs were smaller than M-SSNs, and ill-defined margins were more frequent in AB-SSNs than in NB-SSNs and M-SSNs. Benign SSNs exhibited irregular shape, target sign, and lower CT values more frequently compared to M-SSNs, whereas the latter demonstrated bubble lucency more commonly compared to the former. Furthermore, AB-SSNs showed more thickened interlobular septa and satellite lesions than M-SSNs and M-SSNs had more pleural retraction than AB-SSNs (all p < 0.017). The three models had AUCs ranging 0.748–0.920 and 0.790–0.912 in the training and external validation cohorts, respectively. A follow-up CT showed nodule progression in four benign SSNs.

Conclusions
The three SSN types have different clinical and imaging characteristics, with some benign SSNs progressing to resemble malignancy.

Critical relevance statement
A good understanding of the imaging features and development trends of benign SSNs may help reduce unnecessary follow-up or interventions. This retrospective study explores the CT characteristics of benign SSNs with a solid component ≤ 5 mm by comparing AB-SSNs, NB-SSNs, and M-SSNs and delineates their development trends via follow-up CT.

Key points
1. Different subsolid nodule types exhibit distinct clinical and imaging features.
2. A miniscule number of benign subsolid nodules can progress to resemble malignancy.
3. Knowing the clinical and imaging features and development trends of benign subsolid nodules can improve management.

Graphical Abstract
A resource competition-based truthful mechanism for IoV edge computing resource allocation with a lowest revenue limit
Authors: Zhang Jixian , Wang Zhemin , Vasilakos Athanasios V. , Li Weidong 
Published: January 2024

AbstractResource allocation in Internet of Vehicles (IoV) edge computing is currently a research hotspot. Existing studies focus on social welfare or revenue maximization. However, there is little research on lowest revenue guarantees, which is a problem of great concern to resource providers. This paper presents the innovative concept of the lowest revenue limit, which enables service providers to preset the revenue B and calculate whether the preset revenue can be achieved under the current supply and demand of resources through mechanism design. This approach is very friendly to service providers and can prevent low revenue and waste of resources. Specifically, we improved the ascending price auction mechanism so that it can be used for multi-resource allocation, the unit prices of different resources are calculated according to the intensity of competition among users, and the winning users and the payment are determined by eliminating users with low cost performance. Our mechanism is not sensitive to resource capacity, works well under deployment constraints in edge computing, and satisfies economic characteristics such as individual rationality and truthfulness. Compared with existing algorithms, our approach is shown to enable the service provider to obtain a higher revenue under a lower resource utilization.
Comparing maximum likelihood and Bayesian methods for fitting hidden Markov models to multi-state capture-recapture data of invasive carp in the Illinois River
Authors: Labuzzetta Charles J. , Coulter Alison A. , Erickson Richard A. 
Published: January 2024

Abstract
Background
Hidden Markov Models (HMMs) are often used to model multi-state capture-recapture data in ecology. However, a variety of HMM modeling approaches and software exist, including both maximum likelihood and Bayesian methods. The diversity of these methods obscures the underlying HMM and can exaggerate minor differences in parameterization.

Methods
In this paper, we describe a general framework for modelling multi-state capture-recapture data via HMMs using both maximum likelihood and Bayesian methods. We then apply an HMM to invasive silver carp telemetry data from the Illinois River and compare the results estimated by both methods.

Results
Our analysis demonstrates disadvantages of relying on a single approach and highlights insights obtained from implementing both methods together. While both methods often struggled to converge, our results show biologically informative priors for Bayesian methods and initial values for maximum likelihood methods can guide convergence toward realistic solutions. Incorporating prior knowledge of the system can successfully constrain estimation to biologically realistic movement and detection probabilities when dealing with sparse data.

Conclusions
Biologically unrealistic estimates may be a sign of poor model convergence. In contrast, consistent convergence behavior across approaches can increase the credibility of a model. Estimates of movement probabilities can strongly influence the predicted population dynamics of a system. Therefore, thoroughly assessing results from HMMs is important when evaluating potential management strategies, particularly for invasive species.
A giant liposarcoma originating from peripancreatic fat tissue with identification using 3D-CT angiography: a case report
Authors: Narita Kiyoshi , Kaneko Hiroshi , Hasegawa Fumiya , Akao Nozomi , Kusafuka Tomoki , Desaki Ryosuke , Ogura Masaomi , Hamada Takashi , Asakawa Kana , Murata Tetsuya 
Published: January 2024

AbstractBackgroundLiposarcoma originating from peripancreatic fat tissue is extremely rare. This case report presents a surgical case of a giant liposarcoma originating from peripancreatic fat tissue with origin identification using 3-Dimensional Computed Tomography Angiography (3D-CTA).Case presentationA 59-year-old female was referred to our hospital with a giant abdominal tumor. Computed tomography revealed a 34 cm tumor composed of fatty tissue, exerting pressure on the posterior aspect of the pancreas. Suspecting liposarcoma, we planned for surgery. At first, the tumor appeared to be intra-abdominal tumor, based on the identification of the tumor’s feeding artery as a branch of the dorsal pancreatic artery using 3D-CTA, we concluded that the liposarcoma originated from the peripancreatic fat tissue and situated in the retroperitoneum. During surgery, we observed a well-capsulated, elastic, yellowish mass without infiltration into surrounding tissues. We carefully dissected the tumor from the greater omentum and transverse mesocolon while preserving the tumor capsule. We ligated the feeding artery at the border with the pancreatic parenchyma and successfully completed the excision of the tumor. The resected specimen weighted 2620 g and was pathologically diagnosed as a well-differentiated liposarcoma. There was no injury to the tumor’s capsule, and the surgical margins were negative.ConclusionsIn this report, we present an extremely rare case of a liposarcoma originating in the peripancreatic fat tissue. The use of 3D-CTA was instrumental in identifying the primary site of this giant tumor, enabling us to guide the surgery and achieve complete resection successfully.
Gallbladder hemorrhage associated with segmental arterial mediolysis: a case report
Authors: Hirose Yuichi , Tajima Yusuke , Sakata Hiroki , Uekusa Toshimasa , Kamada Kentaro , Ikehara Takashi , Matsuda Izuru , Yoneyama Satomi , Hidemura Akio , Suzuki Hiroyuki 
Published: January 2024

Abstract
Background
Gallbladder hemorrhage is a rare but fatal condition. The reported causes of gallbladder hemorrhage include iatrogenesis, atherosclerotic changes in the cystic arteries, acute cholecystitis or cholelithiasis, malignancy, trauma, hemophilia, pseudoaneurysm, and the use of oral anticoagulant medications. Recently, segmental arterial mediolysis (SAM) has been reported as a possible etiology of life-threatening abdominal, retroperitoneal, and intracranial hemorrhages. However, no previous reports have described the association between gallbladder hemorrhage and SAM.

Case presentation
A 59-year-old man was transferred to our hospital complaining of upper abdominal pain and vomiting. Contrast-enhanced computed tomography revealed high-density images of the gallbladder and common bile duct. However, there were no obvious findings of gallstones, cholecystitis, tumors, or aneurysms. He was diagnosed with gallbladder hemorrhage and bile duct obstruction. We performed a laparoscopic cholecystectomy after endoscopic biliary drainage. The gross appearance of the surgically resected specimen showed 12 small (3–12 mm), slightly elevated lesions on the gallbladder mucosa. Histologically, these slightly elevated lesions consisted of dilated muscular arteries of the gallbladder wall with fibrinoid degeneration of the media and focal loss of the internal and external elastic laminae. The histopathological diagnosis was confirmed as SAM.

Conclusions
To the best of our knowledge, this is the first reported case of a gallbladder hemorrhage associated with SAM. Our case report shows that SAM can cause gallbladder hemorrhage, suggesting that SAM should be considered in the differential diagnosis of gallbladder hemorrhage.