bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activism Fatigue among Former Muslims
Authors: Richter Lena 
Published: January 2025

Abstract
This empirical article presents an ethnographic, longitudinal and comparative study on nonreligion in urban Morocco and the diaspora in Western Europe. Central to the article is the question of why most former Muslims, despite their wish to change the status quo, refrain from activism. Drawing on 50 in-depth interviews conducted between 2019 and 2023 with young, educated, middle- and upper-class atheists and agnostics, the study shows that the motivation not to engage in the debate can be manifold. In Morocco, legal, professional and social risks discourage open expression of nonreligion, while many feel fatigued by repetitive debates and negative responses. In Europe, where anti-Islam sentiments are prevalent, former Muslims often avoid the topic of leaving Islam for a different reason, namely, to prevent bolstering negative stereotypes about Muslims. This article aims to compare the various motives for non-engagement that emerge within the different minority and majority settings.
Differences between private and public primary health care centers and differences between men and women in antihypertensive care and cardiovascular prevention in all patients with hypertension treated in primary care in Stockholm County, Sweden
Authors: Wändell Per , Norrman Anders , Eriksson Julia , Ivarsson Charlotte , Gudjonsdottir Hrafnhildur , Hagströmer Maria , Lundh Lena , Hasselström Jan , Brynedal Boel , Sandlund Christina , Carlsson Axel C. 
Published: January 2025

Abstract

Aims
To study differences in cardiovascular prevention and hypertension management in primary care in men and women, with comparisons between public and privately operated primary health care (PHC).

Methods
We used register data from Region Stockholm on collected prescribed medication and registered diagnoses, to identify patients aged 30 years and above with hypertension. Age-adjusted logistic regression was used to calculate odds ratios (ORs) with 99% confidence intervals (99% CIs) using public PHC centers as referents.

Results
In total, 119,267 patients with a registered hypertension diagnosis at their primary care center were included; 58,239 men and 61,028 women. In terms of co-morbidities and medications, there were some differences between privately and publicly run PHC: registered diagnosis of dementia, which was higher at private PHC, age-adjusted OR 1.80 (1.24–2.69). For lifestyle counseling, privately run PHC had a higher rate of registered counseling for tobacco 1.17 (1.06–1.29), physical activity 1.13 (1.06–1.17), unhealthy diet 1.08 (1.04–1.13), and counseling according to highest prioritized level of advice stated by national guidelines 1.14 (1.09–1.18). Differences in comorbidities between men and women were found, with higher frequencies of coronary heart disease, congestive heart failure, atrial fibrillation, stroke, diabetes, and gout among men. Regarding antihypertensive treatment, women received less treatment of calcium channel blockers and ACE inhibitors, but more of angiotensin receptor blockers.

Conclusions
These findings highlight the need for targeted preventive efforts in PHC, especially for male patients, to address disparities in cardiovascular health outcomes. Small differences in preventive measures between public and privately run PHC suggest generally consistent care across healthcare ownership models.
Observational pilot using a Data to Care intervention strategy to promote HCV re-engagement and cure for persons with HIV/HCV co-infection who are out of care
Authors: Wegener Maximilian , Gosselin Deborah , Brooks Ralph , Speers Suzanne , Villanueva Merceditas 
Published: January 2025

Abstract

Background
With Direct Acting Antivirals for Hepatitis C virus (HCV), cure is possible in > 95% including those with HIV/HCV co-infection. Achieving strategic targets for cure requires addressing barriers including suboptimal care engagement. We adapted Data to Care (D2C), a public health strategy designed to identify and link persons out of care (OOC) for HIV, for persons with HIV/HCV co-infection untreated for HCV.

Methods
In partnership with Connecticut Department of Public Health (DPH), persons OOC for HIV (defined as no HIV surveillance laboratory tests from 10/1/2018–10/1/2019) were matched to a list of persons co-infected with HIV/HCV (through 12/31/2019). We used a three-phase follow-up approach (pre-work, case conferencing, and Disease Intervention Specialist (DIS) follow-up) to track outreach outcomes and re-engagement/HCV cure success.

Results
There were 90 HIV/HCV co-infected persons who were OOC for HIV. The pre-work and case conferencing phases determined that 33 (36.7%) had previous HCV cure or were in treatment. There were 41 eligible for DIS-follow-up of which 21 (51%) were successfully contacted and 7 (33%) successfully re-engaged (kept appointment with HCV provider). No new HCV treatment initiations were recorded.

Conclusions
Using a D2C approach, we identified and conducted outreach to persons who were OOC for HIV to promote HCV treatment. This approach resulted in intensive data clean-up and outreach efforts which produced modest re-engagement and no HCV treatment initiations. Future studies should develop alternative and complementary interventions to promote effective re-engagement and HCV treatment.
Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival
Authors: Komza Monika , Khatun Jesminara , Gelles Jesse D. , Trotta Andrew P. , Abraham-Enachescu Ioana , Henao Juan , Elsaadi Ahmed , Kotini Andriana G. , Clementelli Cara , Arandela JoAnn , Ghaity-Beckley Sebastian El , Barua Agneesh , Chen Yiyang , Berisa Mirela , Marcellino Bridget K. , Papapetrou Eirini P. , Poyurovsky Masha V. , Chipuk Jerry Edward 
Published: January 2025

Abstract
One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic adaptations upon acute loss of glucose metabolism. Here, we investigated a potent small molecule inhibitor to Class I glucose transporters, KL-11743, using glycolytic leukemia cell lines and patient-based model systems. Our results reveal that while several metabolic adaptations occur in response to acute glucose uptake inhibition, the most critical is increased mitochondrial oxidative phosphorylation. KL-11743 treatment efficiently blocks the majority of glucose uptake and glycolysis, yet markedly increases mitochondrial respiration via enhanced Complex I function. Compared to partial glucose uptake inhibition, dependency on mitochondrial respiration is less apparent suggesting robust blockage of glucose uptake is essential to create a metabolic vulnerability. When wild-type and oncogenic RAS patient-derived induced pluripotent stem cell acute myeloid leukemia (AML) models were examined, KL-11743 mediated induction of mitochondrial respiration and dependency for survival associated with oncogenic RAS. Furthermore, we examined the therapeutic potential of these observations by treating a cohort of primary AML patient samples with KL-11743 and witnessed similar dependency on mitochondrial respiration for sustained cellular survival. Together, these data highlight conserved adaptations to acute glucose uptake inhibition in diverse leukemic models and AML patient samples, and position mitochondrial respiration as a key determinant of treatment success.
Review of upper extremity passive joint impedance identification in people with Duchenne Muscular Dystrophy
Authors: Filius Suzanne J. , Papa Kyriacos , Harlaar Jaap 
Published: January 2025

Abstract
Duchenne Muscular Dystrophy (DMD) progressively leads to loss of limb function due to muscle weakness. The incurable nature of the disease shifts the focus to improving quality of life, including assistive supports to improve arm function. Over time, the passive joint impedance (Jimp) of people with DMD increases. Force-based controlled motorised arm supports require a clear distinction between the user’s movement intention and passive forces, such as passive Jimp. Therefore, Jimp identification is essential. This review aims to define Jimp, identify factors influencing it, and outline experimental methods used for quantification, with a focus on the upper extremities in DMD. A literature review was performed in May 2021 and updated in March 2024 using SCOPUS, PubMed, IEEEXplore, and WebOfScience. The results reveal confusion in definitions and show various Jimp measuring practices for both DMD and individuals without muscle weakness. This study presents an overview and lists important parameters affecting passive Jimp, such as the joint’s position, velocity and the multi-articular nature of the upper arm muscles. For personalised passive Jimp compensation in arm supports, ramp-type perturbations with constant velocity across the full joint range appear most optimal for identifying the elevated and non-linear nature of the passive Jimp in DMD.
Improving preparedness for time critical prehospital care: a descriptive study of the first responder system in Central Norway
Authors: Lindeman Andreas , Næss Lars Eide , Vesterhus Lars , Bakken Ann-Britt Maude , Krüger Andreas , Haugland Helge 
Published: January 2025

Abstract

Background
First responders exist in several countries and have been a prehospital emergency medical resource in Norwegian municipalities since 2010. However, the Norwegian system has not yet been studied. The aim of this study was to describe the first responder system in Central Norway and how it is used as a supplement to emergency medical services (EMS).

Methods
We described incidents with dispatch of first responders in the catchment area of the Emergency Medical Communication Center of Sør-Trøndelag in Central Norway, using retrospective data recorded in the Norwegian Emergency Medical Information System between 2019 and 2023.

Results
First responders were dispatched to 460 incidents during the period. Of these, 441/460 (96%) incidents were assessed as “acute”, and 135/460 (29%) were assessed as possible cardiac arrests. Four large rural municipalities accounted for 234/460 (51%) of the incidents. One in four patients, 112/449 (25%), died within 30 days. EMS had a median response time of 29 min in our sample.

Conclusion
First responders are almost exclusively dispatched to high-severity incidents, with suspected cardiac arrest being the most common dispatch criteria. Our findings suggest that the first responder system contributes to rapid response in cases of acute illness and injury, especially in rural areas.
Blood-based epigenome-wide association study and prediction of alcohol consumption
Authors: Bernabeu Elena , Chybowska Aleksandra D. , Kresovich Jacob K. , Suderman Matthew , McCartney Daniel L. , Hillary Robert F. , Corley Janie , Valdés-Hernández Maria Del C. , Maniega Susana Muñoz , Bastin Mark E. , Wardlaw Joanna M. , Xu Zongli , Sandler Dale P. , Campbell Archie , Harris Sarah E. , McIntosh Andrew M. , Taylor Jack A. , Yousefi Paul , Cox Simon R. , Evans Kathryn L. , Robinson Matthew R. , Vallejos Catalina A. , Marioni Riccardo E. 
Published: January 2025

Abstract
Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is open to measurement error through recall bias. Instead, molecular data such as blood-based DNA methylation (DNAm) could be used to derive a more objective measure of alcohol consumption by incorporating information from cytosine-phosphate-guanine (CpG) sites known to be linked to the trait. Here, we explore the epigenetic architecture of self-reported weekly units of alcohol consumption in the Generation Scotland study. We first create a blood-based epigenetic score (EpiScore) of alcohol consumption using elastic net penalized linear regression. We explore the effect of pre-filtering for CpG features ahead of elastic net, as well as differential patterns by sex and by units consumed in the last week relative to an average week. The final EpiScore was trained on 16,717 individuals and tested in four external cohorts: the Lothian Birth Cohorts (LBC) of 1921 and 1936, the Sister Study, and the Avon Longitudinal Study of Parents and Children (total N across studies > 10,000). The maximum Pearson correlation between the EpiScore and self-reported alcohol consumption within cohort ranged from 0.41 to 0.53. In LBC1936, higher EpiScore levels had significant associations with poorer global brain imaging metrics, whereas self-reported alcohol consumption did not. Finally, we identified two novel CpG loci via a Bayesian penalized regression epigenome-wide association study of alcohol consumption. Together, these findings show how DNAm can objectively characterize patterns of alcohol consumption that associate with brain health, unlike self-reported estimates.
Comparison of the Effectiveness of Paracetamol and Ibuprofen in the Management of Patent Ductus Arteriosus in Preterm Neonates: A Randomized Controlled Trial
Authors: Shah S. Mohsin Ali , Khan Shaista Azeem , Sadiq Faran , Gul Ruba , Sadiq Faizan , Khan Misbah Ullah , Khan Muhammad Khalid , Uzma Faryal , Khan Arooj , Khan Sabir 
Published: January 2025

Abstract

Background
Patent ductus arteriosus is one of the most common cardiac conditions affecting the neonates. Considering the lack of studies done on this topic in healthcare settings in Khyber Pakhtunkhwa province, this study aims to find out the comparative effectiveness of paracetamol and ibuprofen in management of PDA in our healthcare setting to conclude a better management option for the condition.

Objective
To find and compare the effectiveness of paracetamol and ibuprofen in the closure of patent ductus arteriosus in preterm neonates.

Methodology
This randomized controlled trial was conducted in the Department of Nursery and Neonatal Intensive Care Unit, Khyber Teaching Hospital, Peshawar, Pakistan, from 10th April 2024 to 10th October 2024. A total of 256 neonates of both genders with patent ductus arteriosus were included. Group A received oral paracetamol, and Group B received oral ibuprofen. The effectiveness of the treatments was evaluated at the end of the treatment period.

Results
The age range in this study was from 48 to 96 h, with a mean age of 71.79 ± 13.10 h in Group A and 73.40 ± 11.81 h in Group B. Efficacy was observed in 107 (83.6%) patients in Group A compared to 90 (70.3%) patients in Group B, showing a statistically significant difference (P = 0.011).

Conclusion
Our study has concluded that paracetamol is more effective than ibuprofen in closing patent ductus arteriosus. The trials were retrospectively registered at NIH Trial Registry (NCT06601114) https://clinicaltrials.gov/study/NCT06601114 dated 15/09/2024.
Light and dark biofilm adaptation impacts larval settlement in diverse coral species
Authors: O’Brien Paul A. , Bell Sara C. , Rix Laura , Turnlund Abigail C. , Kjeldsen Shannon R. , Webster Nicole S. , Negri Andrew P. , Abdul Wahab Muhammad A. , Vanwonterghem Inka 
Published: January 2025

Abstract

Background
Recovery of degraded coral reefs is reliant upon the recruitment of coral larvae, yet the mechanisms behind coral larval settlement are not well understood, especially for non-acroporid species. Biofilms associated with reef substrates, such as coral rubble or crustose coralline algae, can induce coral larval settlement; however, the specific biochemical cues and the microorganisms that produce them remain largely unknown. Here, we assessed larval settlement responses in five non-acroporid broadcast-spawning coral species in the families Merulinidae, Lobophyllidae and Poritidae to biofilms developed in aquaria for either one or two months under light and dark treatments. Biofilms were characterised using 16S rRNA gene sequencing to identify the taxa associated with settlement induction and/or inhibition.

Results
We show that light and biofilm age are critical factors in the development of settlement inducing biofilms, where different biofilm compositions impacted larval settlement behaviour. Further, we show that specific biofilm taxa were either positively or negatively correlated with coral settlement, indicating potential inducers or inhibitors. Although these taxa were generally specific to each coral species, we observed bacteria classified as Flavobacteriaceae, Rhodobacteraceae, Rhizobiaceae and Pirellulaceae to be consistently correlated with larval settlement across multiple coral species.

Conclusions
Our work identifies novel microbial groups that significantly influence coral larval settlement, which can be targeted for the discovery of settlement-inducing metabolites for implementation in reef restoration programs. Furthermore, our results reinforce that the biofilm community on coral reef substrates plays a crucial role in influencing coral larval recruitment, thereby impacting the recovery of coral reefs.
Warrick score in rheumatoid-arthritis interstitial lung disease: a promising tool for assessing the extent and progression of lung involvement
Authors: Karadag Duygu Temiz , Dogan Sevtap , Gokcen Neslihan , Cagdas Oznur Sadioglu , Yazici Ayten , Cefle Ayse 
Published: January 2025

Abstract

Background
The clinical manifestations and course of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) exhibits considerable heterogeneity. In this study, we aimed to explore radiographic progression over a defined period, employing the Warrick score as a semi-quantitative measure in early RA-ILD, and to assess the associated risk factors for progression.

Methods
RA-ILD patients underwent consecutive Warrick scoring based on initial high-resolution computed tomography (HRCT) at diagnosis and the first follow-up. Associations between Warrick scores, pulmonary function tests, and patient characteristics were analyzed. The ROC curve assessed the predictive performance of the Warrick score change rate for ILD progression, while multivariable logistic regression analysis identified risk factors for progression.

Results
Significant correlations were found between Warrick scores and age at RA-ILD diagnosis, age at ILD diagnosis, and baseline DAS28-ESR. For the severity score, correlations were r = 0.359, r = 0.372, and r = 0.298 (p = 0.001, p < 0.001, p = 0.014, respectively); for the extent score, r = 0.364, r = 0.318, and r = 0.255 (p = 0.001, p = 0.005, p = 0.038, respectively); and for the total score, r = 0.376, r = 0.367, and r = 0.280 (p < 0.001, p = 0.001, p = 0.022, respectively). Annual changes in severity, extent, and total Warrick scores showed sensitivities of 91–97% and specificities of 98% for predicting progression over a 5-year follow-up. Cut-off values were 0.0278 for the severity score (AUC 0.954), 0.0227 for extent score (AUC 0.976), and 0.0694 for total score (AUC 0.946). Warrick severity, extent, and total scores increased significantly during follow-up. Age > 50 years (OR 7.7; p = 0.028) and baseline usual interstitial pneumonia (UIP) pattern (OR 3.1, p = 0.041) were identified as risk factors for progression.

Conclusions
Advanced age and UIP pattern were significant risk factors for progression. Warrick scoring may may help predict progression in RA-ILD, particularly through changes in severity, extent, and total scores. Due to the retrospective design and small sample size, further prospective studies with larger cohorts are needed to confirm these findings and validate Warrick scoring as a reliable marker for RA-ILD progression.
Vibration control and energy harvesting of adjacent structures by electromagnetic dampers considering soil-structure interaction
Authors: Kang Xiaofang , Wu Zongqin , He Wei , Wang Xinqi , Jiang Xueqin 
Published: January 2025

Abstract
With rapid urbanization, the increasing density of buildings in urban areas has forced us to consider interactions between adjacent structures. However, most studies have focused on fixed foundations, neglecting soil-structure interactions (SSI). This paper addresses this gap by investigating the optimization of two adjacent structures using electromagnetic inerter dampers (EMID) under SSI. The EMID system, equipped with energy harvesting capabilities, was optimized using the Monte Carlo search method, with results demonstrating a significant reduction in dynamic response. Specifically, frequency and time domain analyses show that the EMID system reduces peak displacement and acceleration by up to 41.23% compared to uncontrolled structures. Additionally, the system efficiently converts seismic energy into electrical energy, with energy harvesting reaching peak values under intense seismic waves, such as those observed in Mexico City earthquake conditions. This innovative system not only enhances seismic performance, particularly in soft soil conditions, but also offers energy resilience by supplying emergency power, thus highlighting its potential for sustainable urban infrastructure.
The Application Value of an Artificial Intelligence-Driven Intestinal Image Recognition Model to Evaluate Intestinal Preparation before Colonoscopy
Authors: Xu Xirong , Liu Jiahao , Qiu Jianwei , Fan Benfang , He Tao , Feng Shichun , Sun Jinjie , Ge Zhenming 
Published: January 2025

Aims/Background Artificial intelligence (AI), with advantages such as automatic feature extraction and high data processing capacity and being unaffected by fatigue, can accurately analyze images obtained from colonoscopy, assess the quality of bowel preparation, and reduce the subjectivity of the operating physician, which may help to achieve standardization and normalization of colonoscopy. In this study, we aimed to explore the value of using an AI-driven intestinal image recognition model to evaluate intestinal preparation before colonoscopy. Methods In this retrospective analysis, we analyzed the clinical data of 98 patients who underwent colonoscopy in Nantong First People’s Hospital from May 2023 to October 2023. Among them, 47 cases were evaluated based on the intestinal preparation map and the last fecal characteristics (Regular group), and 51 cases were evaluated using an AI-driven intestinal image recognition model (AI group). The duration of colonoscopy examination, intestinal cleanliness, incidence of adverse reactions, and satisfaction with intestinal preparation of the two groups were analyzed. Results The time for colonoscopy in the AI group was shorter than that in the Regular group, and the intestinal cleanliness score in the AI group was higher than that in the Regular group (p < 0.05). The incidence of adverse reactions in the AI group (3.92%) was lower than that in the Regular group (10.64%), but the difference was not statistically significant (p > 0.05). The satisfaction rate of intestinal preparation in the AI group (96.08%) was comparable to that of the Regular group (82.98%) (p > 0.05). Conclusion Compared with the assessment based solely on the intestinal preparation map and the last fecal characteristics, the application of AI intestinal image recognition model in intestinal preparation before colonoscopy can shorten the time of colonoscopy and improve intestinal cleanliness, but with comparable patient satisfaction and safety.