bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of sample acidification and extract storage on hormone receptor-mediated and oxidative stress activities in wastewater
Authors: Yu Maria , Mandava Geeta , Lavonen Elin , Oskarsson Agneta , Lundqvist Johan 
Published: December 2023

Abstract

An underemphasized aspect of sampling strategies in effect-based in vitro testing is to determine suitable collection and preparation techniques. In the current study, the impact of sample acidification on bioactivities was assessed using in vitro bioassays for hormone receptor-mediated effects (estrogen receptor [ER] and androgen receptor [AR]) and the oxidative stress response (Nrf2 activity). Sampling was conducted at a recently upgraded Swedish wastewater treatment plant. Future plans for the treated wastewater include reuse for irrigation or as a potential drinking water source. In the AR and Nrf2 assays, acidification decreased bioactivities in the wastewater influent sample extracts, whereas acidification increased bioactivities following further treatment (disc filtration). In the ER assay, acidification had no impact on the observed bioactivities in the sample extracts. A secondary objective of the study was to assess the stability of the sample extracts over time. Lower activities were detected in the ER and AR assays in all extracts after storage for approximately 1 year. Nrf2 activities did not decrease over time, but rather increased in some of the acidified sample extracts. Overall, the findings suggest that sampling strategies involving acidification may need to be tailored depending on the selected bioassay(s) and the type of wastewater treatments being assessed.
Contextualizing institutional capacity in water governance framework: a literature review
Authors: Raja Ariffin Raja Noriza , Sawon Sanisah , Abd Rahman Nur Hairani , Hanafi Hanira , Zahari Rustam Khairi 
Published: December 2023

AbstractReliable water governance will ensure the strength and sustainability of an institution. The rising needs for water warrant a thorough study of critical variables of water governance. These variables are crucial for the development of a sound institutional framework. However, there were still insufficient studies that systematically review the existing literature in this field. Hence, the current study aims to examine the key components of the institutional framework for water governance. This study was guided by PRISMA 2020 in its systematic searching strategy on three databases, namely Web of Science, Scopus, and ScienceDirect. Articles for the period of 2018–2022 were screened. The process resulted in the selection of 20 related studies which were then assessed using the Mixed-Method Appraisal Tool (MMAT). Thematic analysis was employed and three themes were identified, namely stakeholders engagement, policy and practices, and water resource management. Based on the pattern of previous studies, the study offered significant contributions to practical purposes and the body of knowledge.
Synthesis of biochar-iron oxide magnetic nanocomposite for efficient and rapid removal of Pb(II) heavy metal from water
Authors: Latifian Behnaz , Taghizade Firozjaee Tahere , Abdi Jafar 
Published: December 2023

Abstract

In this study, magnetic biochar-iron oxide (MBC-IO) nanocomposite was easily synthesized as a strong adsorbent to remove toxic Pb(II) heavy metals from aqueous solutions. The physical and chemical properties of the prepared adsorbent were analyzed using SEM, FTIR, XRD, BET, and zeta-potential analyses. An experimental design, using the response surface methodology (RSM), was implemented to study the effect of operational parameters on the Pb(II) adsorption performance. The maximum adsorption capacity of MBC-IO nanocomposite was found to be 504 mg/g, at an adsorbent dosage of 0.08 g/L, pH 7, contact time of 10 min, and initial lead concentration of 50 mg/L. The kinetics and isotherm studies illustrated that the adsorption data were well described by pseudo-second-order and Langmuir models, respectively. In addition to rapid Pb2+ removal, the synthesized adsorbent was also employed to compare the adsorption capability of Cd2+, Co2+, and Ni2+ cations that had significant efficiency in the removal of heavy metals. The reusability investigation depicted that MBC-IO nanocomposite exhibits magnetic properties, enabling its facile separation from aqueous solutions with the assistance of an external magnetic field. These capabilities make the synthesized nanocomposite a good candidate for water purification industries.
Efficient degradation of antibiotic wastewater by biochar derived from water hyacinth stems via periodate activation: pyridinic N and carbon structures improved the electron transfer process
Authors: Duan Wanqing , Zhang Ming , Zhou Runjuan 
Published: December 2023

Abstract

Biochar-activated periodate (PI) is a promising technology toward antibiotic wastewater purification. However, the mechanism of pyrolysis temperature on PI activation efficiency by biochar has not yet been revealed. Herein, this work selected water hyacinth stems as raw materials to prepare biochar with different pyrolysis temperatures (400, 500, 600, and 700 °C), and applied it to degrade tetracycline (TC) wastewater through PI activation. The results show that biochar with a pyrolysis temperature of 700 °C (BC-700) possesses the best TC degradation performance (∼100% within 30 min). Besides, the degradation of TC by BC-700 is less interfered by coexisting anions and water matrix, and exhibits good reusability. Quenching experiments and open circuit voltage tests verified that IO3•, 1O2, and reactive complex BC-PI* are active species involved in TC degradation. In addition, by constructing the relationship between biochar surface properties and degradation rate kobs, it was revealed that the dominant role of pyridinic N in PI adsorption and formation of reactive complexes as well as the promotion of sp2-hybridized carbon in the electron transfer process. This work provides novel insights into the application of biochar in antibiotic wastewater treatment via PI activation.
Hot Melt Extrusion Technique for Developing Pharmaceutical Co-crystals: A Review
Authors: Rathi Ritu , Sanshita  , Singh Inderbir 
Published: December 2023

Background:
In the era of pharmaceutical research and development, the most challenging aspect is to enhance the physicochemical properties of drugs. Hot Melt Extrusion (HME) is a solvent-free, one-step, continuous, scalable, and industrially feasible method for developing pharmaceutical co-crystals. Co-crystallization, as a technique, has gained significant attention for its potential to modify various physicochemical properties of drugs like solubility, stability, compressibility, permeability, taste masking, and therapeutic efficacy

Methods:
We determine the characteristic features of HME and explore published literature using the keywords, HME, co-crystals, and PAT, in databases, such as PubMed, Google Scholar, ScienceDirect, and Research Gate.

Result:
The present review embarks on a detailed journey through the multifaceted domain of HME and its pivotal role in co-crystal development. The process parameters, such as temperature, extruder type, screw configuration, screw speed, and feed rate, are involved in determining the characteristics of the co-crystals produced. Additionally, the review explores the role of materials, including Active Pharmaceutical Ingredients (APIs), plasticizers, polymers, and other pharmaceutical aids, underlining their impact on co-crystal development. The existing literature on HME and its application for pharmaceutical co-crystal production is comprehensively surveyed.

Conclusion:
The review highlights the utility of Process Analytical Technology (PAT) in real-time process control. The role of HME in the future of pharmaceutical co-crystal development is discussed, making this review essential for researchers and industry professionals alike.
Dietary adherence and the associated factors among Indonesian patients with type 2 diabetes: what should we be concerned about?†
Authors: Khusna Rohmah Puriana , Pangastuti Heny Suseani , Wicaksana Anggi Lukman 
Published: December 2023

Abstract

Objective
To identify the level of dietary adherence for particular foods and determine which are challenging for patients with diabetes in Indonesia, as well as the associated factors.

Methods
This study was conducted in a primary health care facility, using a cross-sectional design. Diabetic patients who had received dietary education, agreed to participate, and adult age were invited. All patients with type 1, gestational, and other types of diabetes who did not join regular meetings of Prolanis and were reported moving or dying were excluded. The data collection used demographic and perceived dietary adherence questionnaires (PDAQs). Moreover, the height, weight, and blood glucose level were recorded. Data were analyzed using Pearson, point biserial correlation, and one-way analysis of variance (ANOVA) tests.

Results
The respondents were mostly female, married, and non-smoking with a mean age of 60.2 ± 8.48 years. Mean score for dietary adherence was 29.7 ± 8.85 with scores from the specific food groups between 0.72 ± 1.89 and 4.60 ± 2.30. The lower scores of adherence were identified on low-sugar foods, high-fiber foods, fish and foods with high omega-3, and olive/organic oils in cooking. Additionally, people living with diabetes for more than 10 years and not having any comorbidity showed a higher score of dietary adherence.

Conclusions
There were 4 groups of foods that had a low score of adherence. Accordingly, health care providers working in primary health care should be concerned about those 4 food groups during diabetes education and counseling. Public health workers should make more efforts to promote consumption of the healthy diet among patients with diabetes, particularly those who have had diabetes for less than 10 years and other comorbidities.
Exploring the research area of direct taxation. An empirical analysis based on bibliometric analysis results
Authors: Manta Eduard Mihai , Davidescu Adriana Ana Maria , Geambasu Maria Cristina , Florescu Margareta Stela 
Published: December 2023

Abstract
The investigation and exploration of the general fiscal field with emphasis on “direct taxation” through the analysis of the published scientific literature, looking at the conceptual, intellectual, and collaborative structure while highlighting the future research directions is aiming to visualize the prevailing knowledge structure in order to help the future researchers and research clusters. A sample of 557 documents was extract from the Web of Science platform for the 1954 - 2022-time range and a bibliometric analysis was applied as a quantitative technique to investigate the scientific literature. The main questions for which this study could offer an answer are: Are there emerging subfields or topics within direct taxations research? Which authors have made significant contributions to the study of direct taxation? But what are the most influential and frequently cited publications? How has the research on direct taxations evolved over time in terms of publication trends? Is there any geographical concentration of research in this area? Which collaborative partnerships are standing out?
Opportunities and Limits of Presidential Activism: Czech presidents compared
Authors: Kopeček Lubomír 
Published: December 2023

Abstract
This article analyses the use of powers by Czech presidents Václav Havel (1993–2003), Václav Klaus (2003–2013) and Miloš Zeman (2013–2023). The text is based on the concept of presidential activism, empirically examining mainly their interactions with governments and legislative vetoes. The results show that important incentives for presidential activism are non-cohesive coalition governments, minority governments, slim government majorities in parliament, the collapse of governments and a chaotic parliament. On the other hand, the internal cohesion of a government acts as a constraint on presidential activism. Popularly elected Zeman interpreted his powers much more widely in appointing and removing governments and ministers than Havel or Klaus, who were elected by parliament. By contrast, Zeman used his legislative powers less than his two predecessors, which was apparently influenced by their low success (with some exceptions) in this area. The president’s political proximity to the government was found to only sometimes limit his agility. Czech presidents have rarely been passive. A specific factor that affected activism, albeit only to a limited extent, was the poor health of Havel and Zeman at certain moments. To reduce systemic risks in the future, it would be useful to define more precisely the rules for appointing and dismissing a government and individual ministers.
ALPPS Procedure for the Treatment of Bilobar Multiple Liver Metastasis from Colorectal Cancer: First Case in RN Macedonia
Authors: Selmani Rexhep , Karadzov Zoran , Begovic Goran , Rushiti Qemal , Memeti Shaban , Dimitrova Magdalena G. , Spirovska Tanja , Atanasova Marija , Selmani Arian 
Published: December 2023

Abstract

Introduction: ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy), is a recently developed procedure, first performed by HJ Schlitt in Regensburg, Germany. The technique developed two stages of hepatectomy. The ALPPS procedure has been introduced to increase the volume of future liver remnant, much more than the other technique, such as PVE (portal vein embolization). The first ALPPS in our country was introduced and performed by our team on May 15th, 2018.

Results: The 60-year-old patient was previously operated on for rectal cancer in 2017 at another institution. The operation was performed with anterior resection and the patient was in long term adjuvant chemotherapy. One year after surgery, the patient has multiple bilobar liver metastases and increased tumor markers that led to instant admission to our institution for liver resection. In the first stage, we performed four metastasectomies on the left lobe with right portal vein ligation and transection on the Cantlie line. The second stage was performed after a CT evaluation on the eighth day, with significant hypertrophy on the left lobe. Pathological findings reported ten metastases on the right lobe with a diameter 1-3 cm. The patient was on the long-term chemotherapy, and after one year he had other MS in the IVa segment of the liver. We also performed a metastasectomy. The patient died 32 months after ALPPS.

Conclusion: ALPPS is a safe and feasible procedure for the treatment of bilobar liver metastasis from colorectal cancer. It could provide long-term survival for patients.
Predictive Admission Risk Factors, Clinical Features and Kidney Outcomes in Covid-19 Hospitalised Patients with Acute Kidney Injury
Authors: Taneska Aleksandra Canevska , Rambabova-Bushljetik Irena , Markovska Zaklina Shterjova , Milenkova Mimoza , Vasileva Adrijana Spasovska , Zafirova Biljana , Pushevski Vladimir , Severova Galina , Trajceska Lada , Spasovski Goce 
Published: December 2023

Abstract

Introduction: In COVID-19 patients, acute kidney injury (AKI) is recognized as a cause of high mortality. The aim of our study was to assess the rate and the predictors of AKI as well as survival among COVID-19 patients.

Methods: We analyzed clinical and laboratory admission data, predictors of AKI and outcomes including the need for renal replacement therapy (RRT) and mortality at 30 days.

Results: Out of 115 patients, 62 (53.9%) presented with AKI: 21 (33.9%) at stage 1, 7(11.3%) at stage 2, and 34 (54.8%) at stage 3. RRT was required in 22.6% of patients and was resolved in 76%. Pre-existing CKD was associated with a 13-fold risk of AKI (p= 0.0001). Low albumin (p = 0.017), thrombocytopenia (p = 0.022) and increase of creatine kinase over 350UI (p = 0.024) were independently associated with a higher risk for AKI. Mortality rates were significantly higher among patients who developed AKI compared to those without (59.6% vs 30.2%, p= 0.003). Low oxygen blood saturation at admission and albumin were found as powerful independent predictors of mortality (OR 0.937; 95%CI: 0.917 – 0.958, p = 0.000; OR 0.987; 95%CI: 0.885–0.991, p= 0.024, respectively). Longer survival was observed in patients without AKI compared to patients with AKI (22.01± 1.703 vs 16.69 ± 1.54, log rank p= 0.009).

Conclusion: Renal impairment is significant in hospitalized COVID-19 patients. The severity of the disease itself is emphasized as main contributing mechanism in the occurrence of AKI, and lower blood saturation at admission is the strongest mortality predictor, surpassing the significance of the AKI itself.
Influence of perfluoroorganic emulsion on morphometric parameters of the liver in a systemic inflammatory response (experimental study)
Authors: Ziamko V. Yu. , Dzyadzko A. M. , Shcherba A. E. , Pushkin S. Yu. , Arshintseva E. V. , Grushin V. N. 
Published: December 2023

Theobjectivewas to study the effect of drug «Oxyphtem»1 on liver morphometric parameters in a systemic inflammatory response.Materials and methods.The experimental study was carried out on male Wistar rats (n= 26). The rats of the experimental group were injected with drug «Oxyphtem» intravenously once. Daily observation was carried out during14 days. Rats were taken out of the experiment on the 15thday under light ether anesthesia. Liver samples were fixed in 10 % neutral formalin in phosphate buffer for 24 hours. Histological preparations were studied using the Measure Pixels image analysis computer program based on a Leica 2000 light microscope.Results.In the intact group of rats, no violations of the liver parenchyma were detected: hepatocytes had clear boundaries, the lamellar structure was preserved and sinusoidal capillaries were not dilated. With the development of the systemic inflammatory response in the liver of rats of the control group, expansion and blood filling of the central veins and sinusoids, violation of the structure of the liver plates, and perinuclear edema of hepatocytes were noted. In the experimental group of rats with the use of drug «Oxyphtem», the preservation of the structure of the liver plates was observed, binuclear hepatocytes were found, and the sinusoids were not expanded. We hypothesize that hepatocyte proliferation and the increase in binuclear hepatic cells were indicative of the regenerative response to systemic inflammatory damage and metabolic demand.Conclusion.The use of drug «Oxyphtem» under conditions of the experimental systemic inflammatory response increases reparative regeneration and adaptation of the liver.
Dysphagia in pediatric intensive care unit patients (review)
Authors: Lisitsa I. A. , Aleksandrovich Yu. S. , Zavyalova A. N. , Lisovskii O. V. , Razumov S. A. 
Published: December 2023

The known negative consequences of intensive care unit stays, summarized as the post-intensive care syndrome (PICS) and including swallowing disorders (dysphagia) are also encountered in pediatric practice.Materials and methods. The non-systematic review of literature sources was carried out. Domestic publications were searched in the database on the elibrary website, foreign publications – in PubMed, Google Scholar, Cichrane Library, Cyberleninka, ResearchGate databases in the period of 1990–2023. When analyzed for the query «Dysphagia in Children», 1,496 results were found, «Post-intensive care syndrome in children» – 82 results. We analyzed 142 full-text publications describing the causes, mechanisms, and clinical presentation of dysphagia in children whose swallowing disorders occurred after hospitalization in intensive care units or were associated with severe somatic diseases.Results. The review analyzes the causes, features of diagnosis and treatment of dysphagia in pediatric patients with PIСS. 5 groups of causes in the structure of PIСS that can lead to the development of dysphagia were considered: infectious-trophic, vegetative-metabolic, neuromuscular, emotional-cognitivecomplications and decreased quality of life compared to the premorbid level. Complications associated with the development of dysphagia lead to increased length of stay in intensive care and hospitalization, lead to the development of malnutrition, aspiration pneumonia and other complications. The mechanisms of dysphagia development in children in intensive care units were analyzed. The main ways of dysphagia progression in pediatric practice are determined.Conclusion. Clarification of the causes and understanding of the mechanisms of dysphagia development in conjunction with the implementation of rehabilitation programs can contribute to the improvement of clinical outcomes in children who have undergone a critical condition in the immediate post-discharge period and in the future.
Análisis de la generación energética a partir del biogás obtenido en la planta de tratamiento de agua residual El Salitre (Bogotá)
Authors: Rodríguez Cortés Lina María 
Published: December 2023

La Planta de Tratamiento de Agua Residual (PTAR) El Salitre trata 7m3/s de agua residual de aproximadamente la mitad de la población de la ciudad de Bogotá. El biogás procedente de la digestión anaerobia de este proceso se compone principalmente de CH4 y CO2. Este trabajo se basa en la recolección y análisis de información de la planta, considerando los datos técnicos de la PTAR, las inversiones, el gasto energético actual y el potencial de ahorro de energía. En este caso se busca evaluar el autoabastecimiento de la planta con la energía disponible de sus subproductos a través de cogeneración. Analizando el escenario actual y los potenciales, se obtienen importantes mejoras en el aprovechamiento energético y la posibilidad de mejorar el proceso con energía térmica que no se aprovecha actualmente. A nivel económico se deben realizar elevadas inversiones que requieren mayor financiación y posiblemente incentivos gubernamentales que resultan rentables considerando la vida útil del sistema propuesto.