bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rivaroxaban plus aspirin vs. dual antiplatelet therapy in endovascular treatment in peripheral artery disease and analysis of medication utilization of different lesioned vascular regions
Authors: Huo SiYan , Cheng Jun 
Published: November 2023

BackgroundIn the management of Peripheral Arterial Disease (PAD), the administration of anticoagulant or antiplatelet agents is imperative. The use of Dual Antiplatelet Therapy (DAPT) in conjunction with rivaroxaban has shown potential in mitigating adverse outcomes. Given the heterogeneity in the pathology of lower limb arteries, there is a compelling case for individualized treatment strategies.MethodsIn a single-center retrospective study on pharmacotherapy for peripheral artery disease, patients were treated with either aspirin combined with rivaroxaban or aspirin coupled with clopidogrel. The primary efficacy outcome encompassed a composite of increases in the Rutherford classification, acute limb ischemia, amputations due to vascular causes, target lesion revascularization, myocardial infarction, ischemic stroke, and cardiovascular death. The primary safety outcome was major bleeding, as defined by the Thrombolysis in Myocardial Infarction (TIMI) criteria; meanwhile, major bleeding as categorized by the International Society on Thrombosis and Haemostasis (ISTH) served as a secondary safety outcome. The study differentiated between two subgroups: patients with only above-the-knee and below-the-knee arterial lesions.ResultsFrom January 2016 to December 2021, 455 patients received either clopidogrel plus aspirin or rivaroxaban plus aspirin following endovascular treatment (EVT). The rivaroxaban group (n = 220) exhibited a lower incidence of primary efficacy outcomes [49.1% vs. 60.4%, hazard ratio (HR) 0.77, P = 0.006] but had more TIMI major bleeding events (5.9% vs. 2.1%, HR 2.6, P = 0.04). ISTH major bleeding events did not show a significant difference, though a higher percentage of rivaroxaban patients discontinued medication due to bleeding (10% vs. 4.7%, HR 2.2, P = 0.03). In the above-the-knee arterial disease subgroup, the rivaroxaban group demonstrated a lower incidence of primary efficacy outcomes (28.2% vs. 45.2%, HR 0.55, P = 0.02). In the below-the-knee arterial disease subgroup, no significant difference was observed in the occurrence of primary efficacy events between the two groups (58.7% vs. 64.8%, HR 0.76, P = 0.14).ConclusionRivaroxaban plus aspirin improved outcomes compared to DAPT in patients with lower extremity artery disease. Similar findings were observed in the above-the-knee artery lesion-only group. However, in the below-the-knee artery lesion-only group, rivaroxaban plus aspirin did not surpass DAPT in efficacy. Regarding safety, rivaroxaban plus aspirin exhibited higher bleeding risks and more frequent treatment discontinuation than aspirin combined with clopidogrel.
Minimally invasive surgery for placement of a subcutaneous EEG implant
Authors: Djurhuus Bjarki D. , Viana Pedro F. , Ahrens Esben , Nielsen Sofie S. , Srinivasan Harishchandra L. , Richardson Mark P. , Homøe Preben , Hasegawa Harutomo , Zarei Ali A. , Gauger Pia L. K. , Duun-Henriksen Jonas 
Published: November 2023

BackgroundA new class of subcutaneous electroencephalography has enabled ultra long-term monitoring of people with epilepsy. The objective of this paper is to describe surgeons' experiences in an early series of implantations as well as discomfort or complications experienced by the participants.MethodsWe included 38 implantation procedures from two trials on people with epilepsy and healthy adults. Questionnaires to assess surgeons' and participants’ experience were analyzed as well as all recorded adverse events occurring up to 21 days post-surgery.ResultsWith training, the implantation could be performed in approximately 15 min. Overall, the implantation procedure was considered easy to perform with only 2 episodes where the implant got fixated in the introducing needle and a new implant had to be used. The explantation procedure was considered effortless. In 2 cases the silicone sheath covering the lead was damaged during the explantation, but it was possible to remove the entire implant without leaving any foreign body under the skin. Especially in the trial on healthy participants, a proportion experienced adverse events in the form of headache or implant-pain up to 21 days post-operatively. In 6 cases, adverse events contributed to the decision to explant and discontinue the study: Four of these cases involved implant pain or headache; One case involved a post-operative local infection; and in one case superficial lead placement resulted in skin perforation a few weeks after implantation.ConclusionThe implantation and explantation procedures are considered swift and easy to perform by both neurosurgeons and ENT surgeons. The implant is well tolerated by most participants. However, headache or pain around the implant can occur for up to 21 days post-operatively as anticipated with any such surgery. The expected benefits from the implant should always outweigh the potential disadvantages.
Prevalence and Antimicrobial Resistance of Escherichia coli Isolates from Chicken Meat in Romania
Authors: Brătfelan Dariana Olivia , Tabaran Alexandra , Colobatiu Liora , Mihaiu Romolica , Mihaiu Marian 
Published: November 2023

The current study was conducted in order to analyze the prevalence of Escherichia coli (E. coli) in samples of chicken meat (100 chicken meat samples), as well as to evaluate the antimicrobial susceptibility of these isolates. A total of 30 samples were positive for E. coli among the collected chicken samples. Most isolates proved to be highly resistant to tetracycline (80%), ampicillin (80%), sulfamethoxazole (73.33%), chloramphenicol (70%) and nalidixic acid (60%). Strong resistance to ciprofloxacin (56.66%), trimethoprim (50%), cefotaxime (46.66%), ceftazidime (43.33%) and gentamicin (40%) was also observed. Notably, one E. coli strain also proved to be resistant to colistin. The antimicrobial resistance determinants detected among the E. coli isolates recovered in our study were consistent with their resistance phenotypes. Most of the isolates harbored the tetA (53.33%), tetB (46.66%), blaTEM (36.66%) and sul1 (26.66%) genes, but also aadA1 (23.33%), blaCTX (16.66%), blaOXA (16.66%), qnrA (16.66%) and aac (10%). In conclusion, to the best of our knowledge, this is among the first studies analyzing the prevalence and antimicrobial resistance of E. coli strains isolated from chicken meat in Romania and probably the first study reporting colistin resistance in E. coli isolates recovered from food sources in our country.
Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin–Boric Acid Solid Dispersion in Turkey Poults Infected with Salmonella enteritidis: A Therapeutic Model
Authors: Hernandez-Patlan Daniel , Solis-Cruz Bruno , Latorre Juan D. , Maguey-Gonzalez Jesus A. , Castellanos-Huerta Inkar , Beyssac Eric , Garrait Ghislain , Vázquez-Durán Alma , López-Arellano Raquel , Méndez-Albores Abraham , Hargis Billy M. , Tellez-Isaias Guillermo 
Published: November 2023

The selection of components within a formulation or for treatment must stop being arbitrary and must be focused on scientific evidence that supports the inclusion of each one. Therefore, the objective of the present study was to obtain a formulation based on ascorbic acid (AA) and Eudragit FS 30D microparticles containing curcumin–boric acid (CUR–BA) considering interaction studies between the active components carried out via Fourier transform infrared spectrometry (FTIR) and differential scanning calorimetry (DSC) to minimize antagonistic effects, and comprehensively and effectively treat turkey poults infected with Salmonella enteritidis (S. enteritidis). The DSC and FTIR studies clearly demonstrated the interactions between AA, BA, and CUR. Consequently, the combination of AA with CUR and/or BA should be avoided, but not CUR and BA. Furthermore, the Eudragit FS 30D microparticles containing CUR–BA (SD CUR–BA MP) showed a limited release of CUR–BA in an acidic medium, but they were released at a pH 6.8–7.0, which reduced the interactions between CUR–BA and AA. Finally, in the S. enteritidis infection model, turkey poults treated with the combination of AA and SD CUR–BA MP presented lower counts of S. enteritidis in cecal tonsils after 10 days of treatment. These results pointed out that the use of an adequate combination of AA and CUR–BA as an integral treatment of S. enteritidis infections could be a viable option to replace the indiscriminate use of antibiotics.
Is There Any Evidence for Hell in the Ifá Literary Corpus?
Authors: Ofuasia Emmanuel 
Published: November 2023

Recent scholarship on Yorùbá theology that has tried to model it after the Abrahamic monotheisms as the distinction between Ọ̀run rere (Heaven) and Ọ̀run àpáàdì (Hell) is now replete but has not, before now, commanded critical scrutiny. Specifically, the works of Ogunnade, Odebolu, Shittu and Odeyemi have argued for a Yorùbá notion of Hell even when there is no evidence for such in the theology and traditional practices of the peoples. The aim of this research, then, is to correct this unreliable and uncharitable misrepresentation of Yorùbá theology. To achieve this aim, this research employs the Kawaida methodology, which thrives on reason and tradition. In reinforcing its stance, this study relies on the sacred ritual archive of the Yorùbá, which is the Ifá corpus, to establish the absence of any form of Ọ̀run àpáàdì, as a place of eternal anguish and suffering for evil doers among the Yorùbá.
DESIGN OF DENTAL AND MOUTH CARE INFORMATION SYSTEM APPLICATION DESIGN
Authors: Laut Deru Marah , Ningrum Nining , Utami Ulfah 
Published: November 2023

Background: Dental and oral health care services (Askesgilut) are planned care services within a certain period of time on an ongoing basis in the simple promotive, preventive, and curative fields to improve the degree of optimal dental and oral health in individual groups, and the community. by a dental and oral therapist (TGM). The results of the initial survey from the medical record or puskesmas information system show that there is no electronic record/recording of Askesgilut services, it is necessary to design an electronic Askesgilut record that is integrated with the information system. This study aims to obtain the design of the Askesgilut TGM information system at the Puskesmas
Method: The design of the information system in this study uses a prototyping system design approach, namely a modern engineering-based design approach which is an interactive process that involves close working relationships between designers and users. The working relationship between designers and users is carried out through the Focus Group Discussion (FGD) method as well as in-depth interviews to obtain information/opinions/suggestions/inputs needed in designing the Askesgilut Information System application that will be used by TGM in Bandung City. This research involves the IT team as the main researcher.
Result: The results of making this application are the first step in developing the Askesgilut application in order to facilitate TGM in carrying out its main tasks.
Conclusion: It is hoped that the design of the Askesgilut Information System will not only make it easier for TGM at the Puskesmas in carrying out their duties, but also can be used by the management at the puskesmas, which can then be directly connected to the Health Office to the Ministry of Health.
THE IMPACT OF THE CORONAVIRUS PANDEMIC ON THE QUALITY OF LIFE AND THE FORMATION OF POPULATION IMMUNITY TO THE SARS-COV-2 VIRUS IN THE OLDER GENERATION 65+ GROUP
Authors: Лепехова С.А. , Киреева В.В. , Иноземцев П.О. , Мансурова Л.Н. , Кукушкина Л.Ю. 
Published: November 2023

Проанализировано влияние пандемии новой коронавирусной инфекции COVID-19 и введение самоизоляции на качество жизни старшего поколения 65+ с оценкой коллективного иммунитета у участников исследования. В протокол исследования были включены 192 человека, являющихся сотрудниками Иркутского научного центра, в том числе 94 — старшей возрастной группы 65+. Все участники были разделены условно на четыре возрастные группы. Возраст обследованных — 21–88 лет. На первом этапе оценивали результаты заполнения опросника EQ-5D-3L с оценкой профиля здоровья, отражающего три уровня проблем в пяти компонентах. В среднем показатель качества жизни по ответам EQ–VAS через 1 год после пандемии снизился по сравнению с данными, полученными после месячного периода самоизоляции. Со слов обследуемых, именно наличие тревожной информации и уровень эмоционального напряжения в обществе стали определяющими при ответах на вопросы анкет. При оценке популяционного иммунитета к вирусу SARS-CoV-2 выявлена положительная динамика в период исследования 2021– 2022 гг., преимущественно за счет мероприятий по вакцинации, количество переболевших участников исследования имело тенденцию к снижению. В результате, популяционный иммунитет к вирусу SARS-CoV-2 в 2021 г. составил 77 %, а в 2022 г. — 87 %. В 2021 г. максимальный уровень серопревалентности выявлен в возрастной группе 60–80 лет (83,5 %), а в 2022 г. — в группе 40–60 лет (93 %).
The impact of the pandemic of the new coronavirus infection Covid-19 and the introduction of self-isolation on the quality of life of the older generation 65+ were analyzed, with an assessment of herd immunity among the study participants. The study protocol included 192 people who are employees of the Irkutsk Scientific Center, including 94 people of the older age group 65+. All participants were divided by us conditionally into four age groups. The age of the examined patients ranged from 21 to 88 years. At the fi rst stage, the results of fi lling out the EQ-5D-3L took part with an assessment of the health profi le, reflecting three levels of problems in fi ve components. On average, the EQ-VAS quality of life indicator decreased a year after the pandemic compared to the data obtained after a month-long period of selfisolation. According to the respondents, it was the presence of disturbing information and the level of emotional tension in society th at became decisive in answering the questions of the questionnaires. When assessing population immunity to the SARS-CoV-2 virus, a positive trend was revealed during the study period of 2021–2022, mainly due to vaccination activities, the number of ill participants in the study tended to decrease. As a result, population immunity to the SARS-CoV-2 virus was 77 % in 2021 and 87 % in 2022. In 2021, the maximum seroprevalence level was detected among the age group 60–80 years old (83.5 %), and in 2022 — in the group 40–60 years (93 %).
ACCELERATED POPULATION AGING AS A CONSEQUENCE OF THE COVID-19 PANDEMIC (review)
Authors: Кобелев И.М. , Сагинбаев У.Р. , Рукавишникова С.А. , Ахмедов Т.А. 
Published: November 2023

Пандемия COVID-19 оказала влияние на многие стороны жизни человека. Одним из последствий коронавирусного периода стало ускоренное старение населения. Данный факт подтверждается в работах многих ученых. Вот лишь некоторые из итогов влияния инфицирования SARS-CoV-2 на здоровье человека: укорочение теломер, увеличение количества нейродегенеративных заболеваний, нарушение функций исполнительной системы, когнитивные нарушения, повышение риска сердечно-сосудистых и цереброваскулярных заболеваний, депрессии, слабоумия, инвалидности, отсутствие вовлеченности в здоровое поведение, увеличение уровня циркулирующего тропонина I и натрийуретических пептидов, проблемы с коагуляцией, низкая экспрессия ангиотензинпревращающего фермента 2, ускорение DeltaAge, раннее сосудистое старение, внешние признаки ускорения процессов старения человека, повышение концентрации мочевины и креатинина. Список обширен, и он постоянно пополняется. Важно и дальше раскрывать механизмы, которые лежат в основе тех или иных последствий коронавирусного инфицирования, чтобы попытаться обратить их вспять и обеспечить людям здоровое биологическое старение.
The COVID-19 pandemic has had an impact on many aspects of human life. One of the consequences of the coronavirus period was the accelerated aging of the population. This fact is confirmed in the works of many scientists. Here are some of the results of the impact of SARS-CoV-2 infection on human health: telomere shortening, increased neurodegenerative disease, dysfunction of the executive system, cognitive impairment, increased risk of cardiovascular and cerebrovascular disease, depression, dementia, disability, lack of involvement in healthy behavior, increased levels of circulating troponin I and natriuretic peptides, problems with coagulation, low expression of angiotensin-converting enzyme 2, DeltaAge acceleration, early vascular aging, external signs of accelerating human aging processes, increased urea and creatinine concentrations. The list is extensive, and it is constantly being replenished. It is important to continue to disclose the mechanisms that underlie certain consequences of coronavirus infection in order to try to reverse them and ensure people healthy biological aging.
CONTINUING WORK AFTER 64 YEARS OF AGE AND POSTURAL BALANCE
Authors: Блохина Н.В. , Дёмин А.В. , Ильницкий А.Н. , Шамратов Р.З. 
Published: November 2023

Цель работы — оценка компонентов постурального баланса у работающих и неработающих мужчин и женщин пожилого возраста. Были обследованы 120 человек 65–69 лет, которые были разделены на две группы: 1-я — 30 женщин и 30 мужчин, которые продолжали трудовую деятельность после выхода на пенсию; 2-я — 30 женщин и 30 мужчин, которые на момент обследования прекратили свою трудовую деятельность. Для комплексной оценки компонентов постурального баланса использовали компьютерный постурографический комплекс «Smart Equitest Balance Manager». Проводили Sensory Organization Test (SOT) и Motor Control Test (MCT). На основании сравнительного анализа SOT и MCT можно сделать вывод, что работающие лица 65–69 лет по сравнению с неработающими людьми того же возраста характеризуются более эффективным поддержанием статического и статодинамического баланса, высокой результативностью и функциональностью их постурального контроля, включая нейромышечный контроль баланса, а также наилучшей балансировкой и управлением центром тяжести при поддержании статического и статодинамического равновесия. Снижение степени участия соматосенсорной, зрительной и вестибулярной информации в постуральном контроле, а также зрительно-моторной координации будет негативно отражаться на продолжении трудовой деятельности людей после 64 лет.
The objective of this study was to assess the components of postural balance among working and non-working men and women aged 65–69. A total of 120 people within the age range of 65–69 were screened. The fi rst group included 30 female and 30 male patients who continued working beyond retirement. The second group comprised 30 women and 30 men who had ceased working by the time of the examination. For comprehensive assessment of postural balance components the computer complex of dynamic postrography «Smart Equitest Balance Manager» was used. Sensory Organization Test (SOT) and Motor Control Test (MCT) were conducted. An analysis of SOT and MCT results showed that compared to non-workers aged 65–69, working men and women of the same age range demonstrated more effective maintenance of static and static-dynamic balance, increased postural control performance, including neuromuscular control of balance, as well as optimal balancing and centre of gravity control while maintaining static and static-dynamic balance. The reduced participation of somatosensory, visual and vestibular information in postural control and visualmotor coordination will negatively impact the ability of people over 64 to continue working.
RISK FACTORS FOR LOW FUNCTIONAL ACTIVITY IN PEOPLE 80 YEARS AND OLDER
Authors: Булгакова С.В. , Тренева Е.В. , Курмаев Д.П. 
Published: November 2023

В мире продолжается глобальное постарение населения, поэтому продление функциональной и когнитивной независимости у людей пожилого, старческого возраста и долгожителей является приоритетной целью систем здравоохранения всех государств. Цель исследования — выявление факторов риска низкой функциональной активности у людей старческого возраста. В исследование были включены 122 человека 80 лет и старше (средний возраст — 84,74±2,98 года). У всех участников проводили сбор жалоб, анамнеза, определяли антропометрические показатели, силу хвата кисти, функциональную активность с помощью батареи тестов SPPB, состав тела. Выявлено, что мужчины 80 лет и старше демонстрировали лучшие функциональные показатели, чем женщины. Пол, возраст и число принимаемых лекарственных препаратов явились значимыми предикторами функциональной активности. Пациенты 80 лет и старше с нормальной функциональной активностью обладали лучшими антропометрическими показателями, составом тела, силой хвата кисти. Депрессия и остеоартрит чаще встречались у людей старческого возраста с низкой функциональной активностью.
The global aging of the population continues in the world, therefore, the extension of functional and cognitive independence in the elderly, senile and centenarians is a priority goal of the healthcare systems of all states. The aim of the study was to identify risk factors for low functional activity in senile people. The study included 122 people aged 80 years and older (mean age 84,74±2,98 years). Complaints were collected from all participants; history; anthropometric indicators, handgrip strength, functional activity using the SPPB battery of tests, body composition were determined. It was found that men aged 80 years and older showed better functional performance than women. Gender, age, and the number of drugs taken were significant predictors of functional activity. Patients at the age of 80 years and older with normal functional activity had better anthropometric parameters, body composition, and hand grip strength. Depression and osteoarthritis were more common in older people with low functional activity.
MODERN VIEW OF PEOPLE FALLING SYNDROME ELDERLY AND SENIAL AGE (literature review)
Authors: Щербук А.Ю. , Донсков В.В. , Щербук Ан.Ю. , Черепанова Е.В. , Мадай Д.Ю. , Щербук Ю.А. 
Published: November 2023

В обзорной статье проанализированы научные публикации, посвященные актуальной проблеме современного общества — синдрому падений людей пожилого и старческого возраста. Продемонстрирована многофакторность синдрома падений, которую необходимо учитывать при проведении диагностических и лечебных мероприятий. Полученная информация позволила выделить наиболее значимые состояния и заболевания, ведущие к увеличению частоты синдрома падений. В работе систематизированы сведения о его причинах и профилактике, диагностике и комплексном лечении пациентов пожилого и старческого возраста. Обращено особое внимание на пострадавших пожилого и старческого возраста с травматическими повреждениями.
The review article analyzes scientific publications devoted to the actual problem of modern society — the syndrome of falls in elderly and senile people. The multifactorial nature of falls is demonstrated, which must be taken into account when carrying out diagnostic and therapeutic measures. The information obtained made it possible to identify the most significant conditions and diseases leading to an increase in the frequency of falls. The paper systematizes information about the causes of falls and the prevention of falls, diagnosis and complex treatment of elderly and senile patients. Attention is drawn to the victims of elderly and senile age with traumatic injuries.