bluuebunny/crossref_metadata_2025_split huggingface dataset:
Annual Conference of the Cataloguing, Classification and Indexing Section of the Nigerian Library Association
Authors: Onohinakpor Josephine E. 
Published: July 2005

PurposeTo report on the 24th Annual Conference of Cataloguing, Classification and Indexing of the Nigerian Library Association, held in October 2004.Design/methodology/approachA summary of the main points of the conference.FindingsThe increased role of technology in the cataloging, classification and indexing functions of technical services remains challenging in many libraries. Special and ongoing staff training is necessary to promote new procedures and efficiencies. Computer support, uninterrupted power supplies, and other issues complicate the progress and force libraries to create new solutions to these and other dilemmas.Originality/valueThis report is of interest to library and information management professionals and those interested in developments in library work in Africa.
International Conference on Developing Digital Institutional Repositories: Experiences and Challenges
Authors: Leung Shirley W. 
Published: July 2005

PurposeTo outline some of the presentations at the International Conference on Developing Digital Institutional Repositories: Experiences and Challenges, held in Hong Kong, SAR, in December 2004.Design/methodology/approachA brief description of some of the presentations at the conference.FindingsWith increasing interest in the subject of institutional repository (IR) among academic and research libraries, the conference served as a useful and timely forum on the topic.Originality/valueA brief conference report of value to library and information management professionals on the theoretical and practical aspects of IR.
Improving Service Delivery for Information Gatekeepers: Report of a Workshop at the World Bank in Nigeria
Authors: Chukwuemeka Onyekatu Charles 
Published: July 2005

PurposeTo present a report on a one‐day workshop entitled “Improving Service Delivery for Information Gatekeepers” held in the World Bank office, 21 December 2004 for participants drawn from selected Ministries and Government parastatals. The World Bank convened the workshop to sensitize the Information Gatekeepers on the expectations of the public; encourage them to sit together, identify knowledge gaps, discuss the issues on ground and map out strategies to meet the challenges.Design/methodology/approachThe paper combines narrative with some analysis and opinions of the discussion.FindingsPresently, the ability of Information Gatekeepers to respond to requests when Nigeria’s Freedom of Information (FOI) bill becomes an act of parliament, is largely uncertain. The writer opines that about 50 percent of Information Gatekeepers in Nigeria’s Judicial system have no direct access to a computer, 65 percent have little direct or indirect interaction with the internet, while nearly 85 percent had not been following progress on the FOI bill.Practical implicationsIt was mooted that the next steps to follow would be to scale up the workshop and incorporate Information professionals in other government ministries as well as members of the academic/university circuit.Originality/valueThis paper is of interest to library and information management professionals.
E‐profile: Scirus1: For Scientific Information Only
Authors: McKiernan Gerry 
Published: July 2005

PurposeTo provide a summary of the main features of a science‐specific search engine.Design/methodology/approachA brief description of the features of Scirus.FindingsScirus is a comprehensive science‐specific search engine on the internet with more than 167 million science‐specific Web pages Scirus is a free search engine developed by Elsevier and is updated monthly. In addition to access to general and specialized full‐text journal, e‐print, report and abstract sources, Scirus also incorporates access to select company homepages, conference information, news pages, patent information, product information, scientists’ homepages, society homepages, and university web sites.Originality/valueOffers information about a new science‐specific search engine.
Report on the 171st National Meeting of the American Association for the Advancement of Science (AAAS)
Authors: Mihram Danielle , Arthur Mihram G. , Gelfand Julia 
Published: July 2005

PurposeTo report on the Annual Meeting of the American Association for the Advancement of Science held in Washington, DC in February 2005.Design/methodology/approachAn overview of the seminars, symposia, workshops and presentations at the conference.FindingsThe theme of the meeting was The Nexus: Where Science Meets Society. The meeting was attended by 4,000 registrants, 105 exhibitors; and 900 members of the press. The meeting highlighted the academic role and infrastructure of technology in different science applications, including publishing, and national policy.Originality/valueA report of interest to library and information management professionals.
Library as Changing Place: Viewpoints from University Undergraduates
Authors: Gelfand Julia 
Published: July 2005

PurposeThis piece aims to demonstrate what undergraduate students consider when they think of the academic library and their personal and academic needs. It also begins to speculate about the library of the future on a growing campus.Design/methodology/approachThe piece considers the views of some US university students.FindingsThe growing emphasis on usability studies and libraries trying to respond to user needs by becoming a more user‐centered organization forces an organization to listen carefully to its users. Libraries remain valued places of community and of learning and teaching. People continue to come to libraries because they offer security, comfort and quiet; are free and commercial‐free; provide a place to be with other people in a learning/cultural environment; offer opportunities to learn, search, inquire and recreate; and afford opportunities for choice and serendipity.Originality/valueOffers some insights into the views of students about the role of the library.
Gadget Review: A Look at Devices for Work, Home and Play
Authors: Fullerton Barbara , Schmidt Aaron 
Published: July 2005

PurposeAims to review some new technology “gadgets”.Design/methodology/approachA review with descriptions of new technologies which might impact library services.FindingsThe proliferation of computer technology has ensured that gadgets play a significant role in our daily routines. They are used at work, home and during playtime. Answers the questions: Which gadget should you use for which task? What brands are good for my lifestyle? The gadgets range from new cell phones, keyboards, headsets, printers, cameras and sunglasses.Originality/valueProvides descriptions of some gadgets of value to information seekers.
Mobile Telephony in Nigeria
Authors: Adomi Esharenana E. 
Published: July 2005

PurposeThis paper aims to describe the development of mobile phone services in Nigeria.Design/methodology/approachA description of the evolution of telecommunications in the country.FindingsIndicates that an increasing number of inhabitants are taking advantage of the global system of mobile communication. The advent of mobile telephony, also suggests that apart from increasing the number of those with access to and use of telephone service it has created more jobs for Nigerians and limited the need to travel. Operators are faced with challenges such as interconnectivity, limited mobile coverage, a shortage of trained and qualified personnel, poor financial capital, among other issues.Originality/valueThis is of interest to information management professionals, particularly those interested in Africa. Paper type General review
Ourmedia: An Overview
Authors: Lasica J.D. 
Published: July 2005

PurposeTo describe Ourmedia. Design/methodology/approach – The piece includes descriptions of the various media types Ourmedia handles, preservation issues, fair‐use interpretations and upcoming developments.FindingsOurmedia is a free open‐source global repository for digital media.Originality/valueProvides information of value to information management professionals.
14th North Carolina Serials Conference: Serials Services in the Eye of the Information Storm
Authors: Gushrowski Barbara A. , Saylor Cynthia E. , Whitt Susan F. 
Published: July 2005

PurposeConference report from a state serials conference which explored changing roles of serials as products and technical service librarians reviewing several key sessions.Design/methodology/approachCoverage and description of papers and presentations at this meeting with highlights.FindingsVaried with the session but conclusions indicate that electronic serials are posing increasing challenges to the selection, processing and archiving of resources.Research limitations/implicationsLiving with changes and working through challenges in the treatment of serials suggests that local practices gain significance and not all institutions must comply with the same model.Practical implicationsConference attendance at this kind of regional meeting is valuable.ValueWill be of interest to selectors, reference librarians and staff in technical services, and the online vendor and information provider communities. Particular emphasis given to new open access publications.
Automating Library Operations at the Delta State University Library, Nigeria
Authors: Benson Adogbeji Oghenevwogaga , Adomi Esharenana E. 
Published: July 2005

PurposeThe study reports on the decision to go forward with plans for library automation, and its details, including the number of computers/their capacity, the networking pattern used in the automation of the Delta State library and the operating systems. A review of the library software currently in use – X‐LIB, and the general features of the software, the required training in general computer application and how to use the X‐LIB, and handle data entry and retrospective conversion is covered. The article also speculates about the future plan of the library and the constraints it may experience due to the automation plan.Design/methodology/approachThe work was based on the report/experience of the Delta State University library in implementing automation with the use of X‐LIB. The researcher adopted a descriptive method to reveal the state of automation of the university library and the experience to date. This is a descriptive case study about implementation of X‐LIB software.FindingsAutomation requires intensive staff training and forces future planning for subsequent phases and developments. Research limitations/implications The obvious implications are scale and financial resources, staff development and how far in the future a library wants to stage this phase of implementation. Many libraries already have invested in this process and refined it but in cases like this institution, library automation is still young.Practical ImplicationsUseful, practical insights based on local experience is what is described.ValueAs a case study other libraries considering this product or going in this direction will find this submission of interest.
Power to the people: the case for Wikipedia
Authors: Lipczynska Sonya 
Published: July 2005

PurposeTo examine the case for the Wikipedia as a major reference tool.Design/methodology/approach – Summarises content of the Wikipedia and looks at the controversy its development has engendered. The controversy is examined with reference to recent press articles and internet postings. The aim is to look at the advantages and disadvantages of the Wikipedia in the light of this controversy, with a view to arriving at a balanced assessment of its value.Findings – Finds that the Wikipedia, through its editorial and up‐keep systems and ability to reflect very recent developments, is a source of unquestioned reference value.Research limitations/implications – The assessment of Wikipedia is brief and the analysis of the controversy surrounding it is confined to a small selection of recent articles and web postings.Practical implications – This assessment provides further exposure of the newly developed Wikipedia and contributes to the growing debate about its value and usefulness.Originality/value – Responds to the growing need for a dispassionate assessment of the Wikipedia and offers informed opinion to library and information workers considering exploiting it as a reference resource.
Effective lysis of lymphoma cells with a stabilised bispecific single‐chain Fv antibody against CD19 and FcγRIII (CD16)
Authors: Bruenke Joerg , Barbin Karin , Kunert Susanne , Lang Peter , Pfeiffer Matthias , Stieglmaier Kristin , Niethammer Dietrich , Stockmeyer Bernhard , Peipp Matthias , Repp Roland , Valerius Thomas , Fey Georg H. 
Published: July 2005

SummaryA recombinant bispecific single‐chain fragment variable antibody (bsscFv), directed against the B‐cell antigen CD19 and the low affinity Fc‐receptor FcγRIII (CD16), was designed for use in the treatment of patients with leukaemias and lymphomas. The Fc‐portions of whole antibodies were deliberately eliminated in this construct to avoid undesired effector functions. A stabilised bsscFv, ds[CD19 × CD16], was generated, in which disulphide bonds bridging the respective variable light (VL) and variable heavy (VH) chains were introduced into both component single‐chain (sc)Fvs. After production in 293T cells and chromatographic purification, ds[CD19 × CD16] specifically and simultaneously bound both antigens. The serum stability of ds[CD19 × CD16] was increased more than threefold when compared with the unstabilised counterpart, while other biological properties were not affected by these mutations. In antibody‐dependent cellular cytotoxicity experiments, ds[CD19 × CD16] mediated specific lysis of both CD19‐positive malignant human B‐lymphoid cell lines and primary tumour cells from patients with B‐cell chronic lymphocytic leukaemia or B‐cell acute lymphoblastic leukaemia. Natural killer cells, mononuclear cells (MNCs) from healthy donors and, in some instances, MNCs isolated from patients after allogeneic stem cell transplantation, were used as effectors. Thus, ds[CD19 × CD16] holds promise for the treatment of CD19+ B‐lineage malignancies.
Essential thrombocythaemia: challenges and evidence‐based management
Authors: Harrison Claire N. 
Published: July 2005

SummaryEssential thrombocythaemia was first described over 70 years ago. This condition is dominated by thrombotic and haemorrhagic complications and, in the long‐term, by risk of transformation to myelofibrosis and/or acute leukaemia. However, it is heterogeneous both clinically and biologically. Here, a review of current concepts in disease aetiology and management is offered with reference to recent focused reviews where appropriate. In addition, five specific areas are discussed in detail: the role of the trephine biopsy, the disease entity prefibrotic myelofibrosis; the recently described Janus kinase 2 (JAK2) mutations; the leukaemogenicity of hydroxyurea (hydroxycarbamide); and lastly, the implications of the results of the Medical Research Council Primary Thrombocythaemia 1 study are explored.
Clinical characteristics, biologic features and outcome for young adult patients with acute lymphoblastic leukaemia
Authors: Nachman James 
Published: July 2005

SummaryYoung adult patients with acute lymphoblastic leukaemia (ALL) represent a unique epidemiologic subgroup in that therapy may be provided by either adult or paediatric oncologists. There seem to be no differences in presenting clinical features, immunophenotypic characteristics, or cytogenetic abnormalities for young adult ALL patients treated on paediatric or adult protocols with the exception of median age (16‐paediatric trials versus 19‐adult trials). There is no evidence to suggest that age within the 16–21 year old subgroup has any prognostic significance. Compared with patients 1–9 years, young adult ALL patients have a lower incidence of favourable cytogenetics t(12; 21) hyperdiploidy, a slightly increased incidence of the t(9;22), and an increased frequency of T cell immunophenotype. Compared with patients >30 years, young adult ALL patients have a significantly lower incidence of the t(9; 22). In multiple studies, there is a consistent, large event‐free survival and survival advantage for young adult patients treated on paediatric versus adult protocols.
Hypermethylation of the suppressor of cytokine signalling‐1 (SOCS‐1) in myelodysplastic syndrome
Authors: Brakensiek Kai , Länger Florian , Schlegelberger Brigitte , Kreipe Hans , Lehmann Ulrich 
Published: July 2005

SummaryTranscriptional silencing because of hypermethylation is now recognised to be a hallmark of human tumours. In contrast to acute myeloid leukaemia (AML), comparably little is known about aberrant methylation in myelodysplastic syndrome (MDS), a heterogeneous clonal stem cell disorder with a risk of transformation into secondary AML of up to 30%. Recent evidence demonstrates that suppressor of cytokine signalling SOCS‐1, a negative regulator of cytokine pathways, may act as a tumour suppressor gene, and inactivation because of hypermethylation was shown in various malignancies. Employing a newly developed quantitative real‐time polymerase chain reaction‐based methylation assay we analysed, for the first time, SOCS‐1 methylation in MDS and found disease‐specific hypermethylation in 27 of 86 MDS patients (31%). Demethylation experiments provided direct evidence that aberrant methylation of SOCS‐1 induces transcriptional silencing in myeloid cells. In addition, by analysing the expression of signal transducers and activators of transcription (STAT)‐induced genes we provide for the first time evidence that the activity of the Janus kinase/STAT pathway is increased in primary patient samples showing SOCS‐1 hypermethylation.
Der(6)t(1;6)(q21–23;p21.3): a specific cytogenetic abnormality in myelofibrosis with myeloid metaplasia
Authors: Dingli David , Grand Francis H. , Mahaffey Victor , Spurbeck Jack , Ross Fiona M. , Watmore Ann E. , Reilly John T. , Cross Nicholas C. P. , Dewald Gordon W. , Tefferi Ayalew 
Published: July 2005

SummaryChromosome anomalies are detected in approximately half of patients with myelofibrosis with myeloid metaplasia (MMM) although none of the most prevalent lesions are specific to the disease. In a prospective cytogenetic study of 81 patients with MMM, we encountered three with an unbalanced translocation between chromosomes 1 and 6 with specific breakpoints; der(6)t(1;6)(q21–23;p21.3). A subsequent Mayo Clinic cytogenetic database search identified 12 patients with this chromosome anomaly among 17 791 consecutive patients. A similar database search from Royal Hallamshire Hospital in Sheffield, UK revealed two additional patients among 8000 cases. The clinical phenotype and survival for each of these 14 patients was typical of MMM. These findings suggested that der(6)t(1;6)(q21–23;p21.3) is a highly specific cytogenetic anomaly that may harbour gene(s) specifically associated with MMM. In a preliminary fluorescence in situ hybridization study, the breakpoints on chromosome 6 in two additional cases were found to be telomeric to the gene for 51 kDa FK506‐binding protein (FKBP51).
The use of digital ‘virtual slides’ in the quality assessment of haematological morphology: results of a pilot exercise involving UK NEQAS(H) participants
Authors: Burthem J. , Brereton M. , Ardern J. , Hickman L. , Seal L. , Serrant A , Hutchinson C. V. , Wells E. , McTaggart P. , De la Salle B. , Parker‐Williams J. , Hyde K. 
Published: July 2005

SummaryWe report the results of a pilot study assessing the use of digital ‘virtual slides’ in haematological quality assessment. Conducted together with the UK National External Quality Assessment Scheme for General Haematology, the study involved 166 separate participants, using the format of a typical assessment exercise. The results revealed substantial concordance of observations made using digital slides with those reported in previous glass slide surveys that used identical cases. Participant feedback strongly supported the use of electronic slides in teaching and assessment roles. Our results suggest roles for this new electronic resource in external quality assessment (EQA), education and continuing professional development.
Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean stomatocytosis/macrothrombocytopenia) is the haematological presentation of phytosterolaemia
Authors: Rees David C. , Iolascon Achille , Carella Massimo , O'Marcaigh Aengus S. , Kendra James R. , Jowitt Simon N. , Wales J. K. , Vora Ajay , Makris M. , Manning Nigel , Nicolaou Anna , Fisher Julie , Mann Anuska , Machin Samuel J. , Clayton Peter T. , Gasparini Paolo , Stewart Gordon W. 
Published: July 2005

SummaryPhytosterolaemia (sitosterolaemia) is a recessively inherited metabolic condition in which the absorption of both cholesterol and plant‐derived cholesterol‐like molecules at the gut is unselective and unrestricted. In haematology, Mediterranean stomatocytosis or Mediterranean macrothrombocytopenia is a poorly understood haematological condition that combines stomatocytic haemolysis with the presence of very large platelets. Five pedigrees showing this haematology were identified. Gas chromatography mass spectrometry (GC‐MS) showed that all of the patients with this highly specific haematology had grossly elevated levels of phytosterols in the blood, diagnostic of phytosterolaemia. All showed mutations in the ABCG5 and ABCG8 previously linked to phytosterolaemia. Three pedigrees showed five new mutations, while two pedigrees showed the common W361X mutation in ABCG8. We draw the following four conclusions: (i) that Mediterranean stomatocytosis/macrothrombocytopenia is caused by an excess of phytosterols in the blood; (ii) that phytosterolaemia, which does not respond to standard statin treatment, can be diagnosed via the distinctive haematology described here, even when the cholesterol is normal; (iii) that phytosterolaemia should be considered in the differential diagnosis of all patients with large platelets; and (iv) that the platelet size should be noted in patients with hypercholesterolaemia.
Empirical antimicrobial monotherapy in patients after high‐dose chemotherapy and autologous stem cell transplantation: a randomised, multicentre trial
Authors: Reich Gernot , Cornely Oliver A. , Sandherr Michael , Kubin Thomas , Krause Stefan , Einsele Hermann , Thiel Eckhard , Bellaire Tanja , Dörken Bernd , Maschmeyer Georg 
Published: July 2005

SummaryWe report on 232 patients undergoing autologous haematopoietic stem cell transplantation (ASCT) entered into a multicentre, randomised trial comparing the efficacy and tolerability of meropenem (MPM) with that of piperacillin/tazobactam (P/T) as empirical antimicrobial first‐line therapy for febrile neutropenia. In 27·6% of patients in the MPM group and 22·4% in the P/T group, therapy was initially supplemented with a glycopeptide for venous catheter infection or bacteraemia because of coagulase‐negative staphylococci. Complete response rate after 72 h was 63·8% in the MPM group and 49·6% in the P/T group (P = 0·034). Overall complete response rate after treatment modification was 94·0% in the MPM group and 93·1% in the P/T group. Median time to defervescence was 2 d in the MPM group and 3 d in the P/T group. The most frequently isolated pathogens were Gram‐positive cocci. Treatment was well tolerated in both groups. One patient (0·4%) died from infection. Empirical first‐line therapy with MPM as well as with P/T is safe and effective in febrile episodes emerging after ASCT. Higher response rates to primary treatment can be achieved with MPM.