bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in geometric patterns of failure in human papillomavirus (HPV)‐associated and HPV‐non‐associated oropharyngeal cancer after definitive radiotherapy
Authors: Yuvnik Trada , Chia Low , Laura O' Connor , Tieu Tieu Thi , Mahesh Kumar , Bradley Beeksma , Daron Cope , Chris Wratten 
Published: December 2023

AbstractIntroductionThe aim of this study was to evaluate and compare the spatial pattern of locoregional recurrences in patients diagnosed with HPV‐associated and HPV‐non‐associated oropharyngeal SCC (OPSCC) treated with definitive radiotherapy.Methods and materialsPatients who had locoregional recurrence following definitive intensity‐modulated radiation therapy were identified at a single tertiary institution. Target volumes were delineated according to the latest consensus international guidelines. Recurrences were classified into five categories based on radiotherapy dose distribution and target volume, using a previously validated methodology; type A (central high dose), type B (peripheral high dose), type C (central elective dose), type D (peripheral elective dose), and type E (extraneous dose). The types of failure were compared between p16‐positive and p16‐negative tumors using the Pearson chi‐square test.ResultsFifty‐eight locoregional recurrences were observed in 36 patients. The majority of recurrences were in nodal locations (66%, 38/58). Among these, 34 (59%) were classified as type A, 6 (10%) as type B, 9 (15%) as type C, 5 (9%) as type D, and 4 (7%) as type E failure. A significant difference was found in the types of failure between p16‐positive and p16‐negative tumors (X2 9.52, p = 0.044). p16‐negative tumors were more likely to have recurrences in a peripheral location compared to p16‐positive tumors (32% vs. 7%). p16‐positive tumor were more likely to have extraneous recurrences (17% vs. 0%).ConclusionOur study results identified a significant difference in patterns of locoregional failure among patients diagnosed with oropharyngeal cancer following consensus‐based tumor delineation and modern radiotherapy. Further confirmatory pattern of failure studies are required to enable greater individualization of radiotherapy for patients diagnosed with oropharyngeal malignancy in the future.
Long‐term outcomes of patients with oral cavity cancer receiving postoperative radiotherapy after salvage neck dissection for cervical lymph node recurrence
Authors: Fujisawa Takeshi , Motegi Atsushi , Hirata Hidenari , Zenda Sadamoto , Hojo Hidehiro , Nakamura Masaki , Oyoshi Hidekazu , Tomizawa Kento , Zhou Yuzheng , Fukushi Keiko , Kageyama Shun‐Ichiro , Enokida Tomohiro , Okano Susumu , Tahara Makoto , Shinozaki Takeshi , Hayashi Ryuichi , Matsuura Kazuto , Akimoto Tetsuo 
Published: December 2023

AbstractBackgroundsWe aimed to clarify the outcomes of postoperative radiotherapy (PORT) after salvage neck dissection for cervical lymph node (LN) recurrence in oral cavity cancer.MethodsWe retrospectively evaluated overall survival (OS), recurrence‐free survival (RFS), recurrence patterns, and adverse events of 51 patients with high‐risk features receiving PORT after salvage neck dissection between 2009 and 2019.ResultsAfter a median follow‐up of 7.4 years from PORT initiation, the 7‐year OS and RFS rates were 66.3% (95% CI: 54.0–81.3) and 54.6% (95% CI: 42.1–70.9), respectively. Age <70 years and isolated LN recurrence were significantly associated with longer OS and RFS. Among the 22 patients who experienced recurrence, 14 experienced recurrence within the radiation field. PORT‐related grade 3 acute mucositis (35%) and late adverse events (osteoradionecrosis [4%] and laryngeal stenosis [2%]) were observed.ConclusionsPORT after salvage neck dissection for cervical LN recurrence achieved good survival with acceptable toxicity.
Harnessing the power of molecular imaging for drug discovery and development
Authors: Luo Xiangning , Tan Boyu , Zhao Xuanyan , Zhang Ziyang , Wang Gang , Wang Tao , Xing Bengang , Song Aiguo 
Published: December 2023

AbstractNon‐invasive, real‐time, dynamic, and quantitative molecular imaging has been developed to facilitate disease diagnosis, drug development, and pathological analysis at the molecular level. Qualitative and quantitative analysis and imaging of physiological processes at the molecular level can be achieved with advanced molecular imaging by employing imaging contrast agents in combination with traditional imaging modalities, such as optical imaging, ultrasound imaging, magnetic resonance imaging, single‐photon emission computed tomography, and positron emission tomography. With the aid of molecular imaging, absorption, distribution, metabolism, excretion, and other processes of drugs in various animals can be monitored quantitatively, and in vivo pharmacokinetics and pharmacodynamics can be simulated before clinical trials, which significantly shorten the period for drug development and reduce the number of animals participating in various tests. Here, the role of molecular imaging in drug target validation, drug screening, drug sensitivity analysis, pharmacokinetics research, drug efficacy evaluation, and other processes of chemical and biological drug research and development is summarized. Molecular imaging has become a powerful and effective tool in the research and development of various drugs for the treatment of a variety of diseases. Advanced molecular imaging can provide important support for disease and drug research, which will accelerate drug discovery and development.
Best practices for supporting and improving pharmacy resident research and quality improvement projects
Authors: Murphy John E. , Azad Aniqa , Barreto Jason N. , Coons Eric M. , Coons James C. , Drury Anna Sahlstrom , Goodlet Kellie J. , Hennessey Erin K. , Jennings Douglas , Kane‐Gill Sandra L. , Morbitzer Kathryn , Pluckrose Dawn M. , Sikand Harminder , Weant Kyle A. 
Published: December 2023

AbstractThe 2023 ACCP Research Affairs Committee was charged with developing a commentary to address best practices in pharmacy resident research and quality improvement projects and to consider methods to overcome the challenges encountered in conducting these projects. Literature regarding best practices was evaluated, and approaches were recommended that might help (1) advance the value of the projects to stakeholders; (2) overcome limited preparation for research by residents and mentors, including writing skills and dissemination experience; (3) overcome challenges related to resources (e.g., time and mentors); and (4) avoid burnout among residents and mentors. Although there are many challenges to completing projects and disseminating the results, studies have provided useful recommendations to help circumvent the barriers.
Characterization and in‐vitro assessment of silicon‐based apatite microspheres for bone tissue engineering applications
Authors: Wee Chien Yi , Lim Quentin Ray Tjieh , Xu Xin , Yang Zhijie , Wang Dong , Thian Eng San 
Published: December 2023

AbstractIn the field of bone tissue engineering, silicon (Si) has been found as an essential element for bone growth. However, the use of silicon in bioceramics microspheres remains limited. In this work, different weight percentages (0.8, 1.6, and 2.4 wt %) of silicon was incorporated into hydroxyapatite and fabricated into microspheres. 2.4 wt % of Si incorporated into HAp microspheres (2.4 SiHAp) were found to enhance functional properties of the microspheres which resulted in improved cell viability of human mesenchymal stem cells (hMSCs), demonstrating rapid cell proliferation rates resulting in high cell density accumulated on the surface of the microspheres which in turn permitted better hMSCs differentiation into osteoblasts when validated by bone marker assays (Type I collagen, alkaline phosphatase, osteocalcin, and osteopontin) compared to apatite microspheres of lower wt % of Si incorporated and non‐substituted HAp (2.4 SiHAp >1.6 SiHAp >0.8 SiHAp > HAp). SEM images displayed the densest cell population on 2.4 SiHAp surfaces with the greatest degree of cell stretching and bridging between neighboring microspheres. Incorporation of silicon into apatite microspheres was found to accelerate the rate and number of apatite nucleation sites formed when subjected to physiological conditions improving the interface between the microsphere scaffolds and bone forming cells, facilitating better adhesion and proliferation.
Loss of Dja2 accompanies pH deviation in lysosomes and lysosome‐related organelles
Authors: Terada Kazutoyo , Endo Motoyoshi , Kiyonari Hiroshi , Takeda Naoki , Oike Yuichi 
Published: December 2023

AbstractThe Dja2 knockout (Dja2−/−) mice had respiratory distress, and >60% died within 2 days after birth. The surviving adult Dja2−/− mice were infertile and the lungs of Dja2−/− mice showed several abnormalities, including the processing defect of prosurfactant protein C in the alveolar epithelial type II cells and the accumulation of glycolipids in enlarged alveolar macrophages. The luminal pH of acidic organelles in Dja2−/− cells was shifted to pH 5.37–5.45. This deviated pH was immediately restored to control levels (pH 4.56–4.65) by the addition of a diuretic, ethyl isopropyl amiloride (EIPA). Although the role of DJA2 in maintaining the pH homeostasis of lysosome‐related organelles is currently obscure, this rapid and remarkable pH resilience is best explained by an EIPA‐sensitive proton efflux machinery that is disorganized and overactivated due to the loss of Dja2.
Ultrahigh capacitive performance of O andMgself‐dual‐doped activated carbon fromAnanas comosusleaf fiber using a redox additive‐based electrolyte
Authors: Awitdrus Awitdrus , Agustino Agustino , Farma Rakhmawati , Iwantono Iwantono , Deraman Mohamad 
Published: December 2023

AbstractBACKGROUNDThe capacitive behavior of a supercapacitor (SC) based on activated carbon derived from biomass is enhanced when a halogenated iodide (in this case, iodide, Iˉ) is added to the acidic aqueous electrolyte. In this work, we prepared ultrahigh capacitive performance of O and Mg self‐dual‐doped activated carbon (AC) fromAnanas comosusleaf fiber (ACLF) via chemical activation at high temperature, followed by activation under the protection of CO2to produce commercially feasible electrodes for commercial‐scale SC devices. The prepared ACLFs were characterized through SEM–EDX, XRD, adsorption/desorption of N2. Moreover, in a 2‐electrode setup, the capacitive activity of the prepared ACLFs were evaluated using cyclic voltammetry and galvanostatic charge/discharge techniques in a redox additive electrolyte (1 M H2SO4 + 0.05 M KI).RESULTThe pairs 3Iˉ/I3ˉ, 2Iˉ/I2, 2I3ˉ/3I2, and I2/IO3ˉ generate reduction–oxidation (redox) peaks in the CV curves and a significant Faradaic plateau in the GCD curves. The ACLF samples delivered an outstanding gravimetric capacitance and energy density as high as 581 F g−1and 80.69 Wh kg−1at a power density of 346.14 W kg−1, respectively.CONCLUSIONThe enhanced capacitive activity is a result of the Faradaic pseudocapacitance associated with the redox‐active ions present in the acidic electrolyte solution. This work describes a facile and economical approach to acquiring a potential candidate of electrode materials for SC devices with exceptional performance, achieved via a redox additive‐based electrolyte system. © 2023 Society of Chemical Industry (SCI).
Advanced purification of isopropanol and acetone from syngas fermentation
Authors: Janković Tamara , Straathof Adrie JJ , Kiss Anton A 
Published: December 2023

AbstractBACKGROUNDIsopropanol and acetone production by syngas fermentation is a promising alternative to conventional fossil carbon‐dependent production. However, this alternative technology has not yet been scaled up to an industrial level owing to the relatively low product concentrations (about 5 wt% in total). This original research aims to develop cost‐effective and energy‐efficient processes for the recovery of isopropanol and acetone from highly dilute fermentation broth (>94 wt% water) for large‐scale production (about 100 ktIPA+AC y−1).RESULTSVacuum distillation and pass‐through distillation enhanced with heat pumps or multi‐effect distillation were efficiently coupled with regular atmospheric distillation and extractive distillation in several innovative intensified downstream processes. Over 99.2% of isopropanol and 100% of acetone were recovered as high‐purity end‐products (>99.8 wt%). Advanced heat pumping (mechanical vapor recompression) and heat integration techniques were implemented to decrease total annual costs (0.109–0.137 USD kgIPA+AC−1), reduce energy requirements (1.348–2.043 kWth h kgIPA+AC−1) and lower CO2 emissions (0.067–0.191 kgCO2 kgIPA+AC−1), resulting in highly competitive recovery processes.CONCLUSIONThe proposed three novel isopropanol and acetone recovery processes from dilute broth significantly contribute to the expansion of sustainable industrial fermentation. Furthermore, this original research is the first one to develop novel pass‐through distillation technology for the complex isopropanol–acetone–water system. All the designed processes are highly economically competitive and environmentally viable. In addition to recovering efficiently both isopropanol and acetone, the designed downstream processes offer the possibility to enhance the fermentation process by recycling all the present microorganisms and reducing fresh‐water requirements. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Revealing the intricate microcosm: Advancing invasive species pollen analysis through scanning microscopy of ultra sculpture
Authors: Al‐Qahtani Wahidah H. 
Published: December 2023

AbstractMicromorphological visualization of plant surface peculiarities provides valuable characters for the precise identification of plant species. Invasive alien species, introduced outside their native range, pose significant ecological, and health challenges. This study focuses on micromorphological investigations of selected invasive plant species belonging to the families Amaranthaceae, Asteraceae, Moraceae, Crassulaceae, Cannabaceae, Fabaceae, Commelinaceae, and Oxalidaceae. The study employs scanning electron microscopy (SEM) to analyze the species micromorphology of pollen structure in depth to characterize the sculpturing patterns. Additionally, the study examines the pollen characteristics of these invasive plants, including shape, size, and fertility, along with exine sculpturing. The maximum polar diameter was observed for Senna tora (41.2 μm). The spines in Achillea fragrantissima were measured to have dimensions of approximately 1.91 μm in length and 2.11 μm in width. The findings shed light on the allergy‐causing potential of these invasive species, providing crucial information for accurate identification and effective management strategies to safeguard the indigenous flora of the region. The study contributes to the knowledge base for botanists, taxonomists, policy makers, climate experts, and biodiversity specialists.Research Highlights
Integrating SEM to analyze the pollen of invasive species.
Unveiling pollen micromorphology of invasive species.
Exploring the microscopic realm of invasive pollen to accurately identify the species.
Mixed ensiling plus nitrate destroy fiber structure of rape straw, increase degradation, and reduce methanogenesis through in vitro ruminal fermentation
Authors: Pu Xuanxuan , Zhang Xiumin , Yi Siyu , Wang Rong , Li Qiushuang , Zhang Wanqian , Qu Jiajing , Huo Jiabin , Lin Bo , Tan Bie , Tan Zhiliang , Wang Min 
Published: December 2023

AbstractBACKGROUNDBetter utilization of rape straw can provide alternative strategies for sustainable ruminant and food production. The research reported here investigated changes in the carbohydrate composition of rape straw as a result of mixed ensiling with whole‐crop corn or inoculated with nitrate, and the consequent effects on ruminal fermentation through in vitro batch culture. The three treatments included: rape straw and corn silage (RSTC), and ensiling treatment of rape straw with whole‐crop corn (RSIC) or with calcium nitrate inoculation (RSICN).RESULTSEnsiling treatment of rape straw and whole‐crop corn or plus nitrate enriched lactic acid bacteria and lactate. The treatments broke the fiber surface connections of rape straw, leading to higher neutral detergent soluble (NDS) content and lower fiber content. Ensiling treatments led to greater (P < 0.05) dry matter degradation (DMD), molar proportions of propionate and butyrate, relative abundance of the phylum Bacteroidetes and genus Prevotella, and lower (P < 0.05) methane production in terms of g kg−1 DMD, molar proportions of acetate, and lower acetate to propionate ratio than the RSTC treatment. The RSICN treatment led to the lowest (P < 0.05) hydrogen concentration and methane production among the three treatments.CONCLUSIONEnsiling treatments of rape straw and whole‐crop corn destroy the micro‐structure of rape straw, promote substrate degradation by enriching the phylum Bacteroidetes and the genus Prevotella, and decrease methane production by favoring propionate and butyrate production. Nitrate inoculation in the ensiling treatment of rape straw and whole‐crop corn further decreases methane production without influencing substrate degradation by providing an additional hydrogen sink. © 2023 Society of Chemical Industry.
Large‐scale separation of alkaloids from Corydalis decumbens by pH‐zone‐refining centrifugal partition chromatography and their anticomplement activity
Authors: Xie Xin‐Xin , Chen Zhong‐Jian , Zhu Quan‐Gang , Yu Qin , Lian Tian‐Yan , Xu Xue‐Lian , Chen Ya , Song Wei‐Hua 
Published: December 2023

Centrifugal partition chromatography in the pH‐zone‐refining mode was successfully applied to the separation of alkaloids from the crude extract of Corydalis decumbens. The experiment was performed with a two‐phase solvent system composed of petroleum ether‐ethyl acetate‐ethanol‐water (5:5:3:7, v/v/v/v) where triethylamine (10 mM) was added to the stationary phase and hydrochloric acid (10 mM) to the mobile phase. From 1.6 g of the crude extract, 43 mg protopine, 189 mg (+)‐egenine, and 158 mg tetrahydropalmatine were obtained with a purity of 98.2%, 94.6%, and 96.7%, respectively. Tetrahydropalmatine showed an interesting anticomplement effect with CH50 0.11 and AP50 0.25 mg/mL, respectively. In a mechanistic study, tetrahydropalmatine interacted with C1, C3, C4, and C5 components in the complement activation cascade.
Partial‐depth search and search pattern comparisons
Authors: Liu Lin , Wang X. Henry , Shen Tongyuan 
Published: December 2023

AbstractThis paper compares consumers' optimal search behaviors and firms' strategic reactions in prices under two modes of search: parallel search and sequential search, with the incorporation of partial search depth that measures the amount of information to evaluate a product. Our analysis shows a series of new results: when products are partially evaluated, search depth is greater under sequential search than under parallel search; consumers search for (on average) more products either under parallel search or sequential search, depending on whether partial‐depth search is chosen; the equilibrium price is higher under parallel (sequential) search when search costs are high (low). Interestingly, parallel search might yield higher equilibrium prices with more products searched, compared with sequential search. This challenges the conventional wisdom in the search literature that more products searched lower prices because of the intensified competition.
Quantifying seasonal variations in space use within the home range of Burbot
Authors: Robinson Tyler J. , Hafs Andrew W. , Fisher Shannon J. , Ueland Jeffrey S. 
Published: December 2023

Abstract

Objective
Advances in acoustic telemetry have assisted biologists in understanding migration patterns, space use, survival, and the effects of human influences on aquatic species. Using fine-scale positioning, fisheries managers can quantify home range size fluctuations throughout the year and even identify spawning areas. Burbot Lota lota population dynamics have been studied across their range, while movement dynamics have been briefly investigated. Our objective was to assess seasonal variations of Burbot space use using estimations of home range size with an attempt to infer spawn timing.

Methods
Thirty-two acoustic-tagged Burbot were used to study home range size in Bad Medicine Lake, Minnesota, from April 2019 to June 2020.

Result
Female estimated home range size was significantly larger than that of males. Estimated home range size increased following ice formation in December and continued through March. Average home range estimates were largest in the middle of March and smallest in April, assumed to be caused by spawning and postspawn behaviors, respectively.

Conclusion
The results suggest that Burbot movement increased during the winter months, which may cause potential increases in vulnerability during spawning. High exploitation rates are possible in situations where spawning and feeding Burbot encounter elevated angling pressure. Future research should continue to assess the movement dynamics and potential site fidelity of Burbot populations by monitoring spawning grounds and if the same areas are used year after year. The results of this study improve the knowledge of areas used by Burbot in lakes, which can assist with management of Burbot in Bad Medicine Lake. Furthermore, we highlighted how Burbot movement increased during spawn timing, which could contribute to increased encounters with anglers.
An observational, patient‐reported outcome study of sleep quality and depression among individuals with overactive bladder syndrome
Authors: Jensen Sally , Walker David , Elsouda Dina , Lockefeer Amy , Kenton Kimberly , Peipert John Devin , Jackson Kathryn L. , Helfand Brian T. , Glaser Alexander P. , Cella David 
Published: December 2023

AbstractIntroductionOveractive bladder (OAB) can adversely affect health‐related quality‐of‐life (HRQoL) and adherence to treatments; however, the extent of their association is unknown. This study sought to characterize Sleep Disturbance, Depression, Fatigue, and patient‐reported medication adherence among adults with OAB in the United States.Materials and MethodsIn this descriptive, observational study, patients completed patient‐reported outcome (PRO) measures of urinary symptoms, anxiety, depression, fatigue, sleep quality, and medication adherence. PRO scores were compared across age, sex, body mass index, and sleep and antidepressant medication‐taking subgroups. Exploratory analyses compared PRO scores between groups and estimated the effect size of differences.ResultsOf 1013 patients contacted, 159 completed the assessments (female: 67.3%; ≥65 years of age: 53.5%; most severe OAB symptom: nocturia). Scale scores for Sleep Disturbance, Fatigue, and Depression were consistent with US population norms. No correlations of moderate or greater magnitude were observed between the severity of lower urinary tract symptoms and Sleep Disturbance, Fatigue, or Depression. When comparing individuals receiving antidepressants with those who were not, almost all outcomes including urinary symptoms, anxiety, and depression were significantly worse. Patients taking antidepressants also had poorer adherence to their OAB medications.ConclusionIn this cohort of individuals with OAB, Sleep Disturbance, Fatigue, and Depression scores were in line with general population reference values; however, among the subgroups analyzed, patients on antidepressants had worse HRQoL and more substantial impacts on medication adherence, highlighting the importance of the assessment and management of depression in this population.