bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytological findings of phosphaturic mesenchymal tumor: Report of a case with summary of prior published cases
Authors: Das Oindrila , Mohin Md , Dey Soumya , Kar Anish , Singhania Pankaj , Adhikari Souvik , Chowdhury Subhankar , Chatterjee Uttara 
Published: October 2023

AbstractPhosphaturic mesenchymal tumor (PMT) is a rare neoplasm causing tumor‐induced osteomalacia (TIO) and is characterized by secretion of FGF23, renal phosphate wasting and hypophosphataemia. It can be completely cured by resection and therefore its diagnosis is of utmost importance. Although the histology is well described, there is sparse literature on cytology of PMT and only three cases have been described so far. A 45‐year‐old lady presented with a non‐tender mass in hard palate for 2 years from which fine‐needle aspiration was done. The smears were paucicellular and showed bland spindle cells embedded in osteoid‐like stromal matrix in a hemorrhagic background. Here we take the opportunity to describe the cytological findings of PMT along with its cytological differentials and a summary of prior published cases.
Childhood trauma and outcome trajectories in patients with longstanding eating disorders across 17 years
Authors: Eielsen Hanna Punsvik , Ulvenes Pål , Hoffart Asle , Rø Øyvind , Rosenvinge Jan H. , Vrabel KariAnne 
Published: October 2023

AbstractBackgroundA large proportion of patients with eating disorders (ED) report experiences of childhood trauma. Latent trajectory analysis in ED samples reveals the complexities in course and outcome and can explore the long‐term impact of adverse experiences in childhood.MethodA total of 84 patients with longstanding ED were included. ED symptoms were assessed by the Eating Disorder Examination interview at discharge from inpatient treatment, and at 1‐, 2‐, 5‐, and 17‐year follow‐up, respectively. Change over time was examined using growth mixture modeling, allowing the number of trajectories to emerge through the data. Prevalence of childhood trauma was assessed, and its relation to class membership was tested.ResultsWe identified four distinct classes: patients with (a) a continuous improvement in the entire follow‐up period, and scores within normal range at the end, “continuous improvement” (54.8%); (b) a high symptom level at baseline and moderate decrease over time, “high and declining” (22.6%); (c) initial ED scores below clinical cut‐off and stable symptoms throughout the course, “consistently low” (14.3%); and (d) with high scores initially, and a significant increase in symptoms over time, “high and increasing” (8.3%). A history of childhood sexual abuse (CSA) was overrepresented in classes with persistently high symptom levels and poor long‐term outcomeDiscussionPatients with longstanding ED displayed considerable diversity in trajectories of symptom change across 17 years. To improve long‐term outcome, enhanced treatment of sequelae from CSA seems essential.Public SignificancePatients with longstanding eating disorders displayed four different trajectories of change in a 17‐year follow‐up study. Although there were significant changes over time, the majority of patients remained within similar symptom levels as they presented with at discharge from inpatient treatment. Exposure to childhood maltreatment was common within the sample. Childhood sexual abuse predicted poor long‐term outcome, which highlights the importance of trauma informed care.
Longitudinal EpiTrack assessment of executive functions following vagus nerve stimulation therapy in patients with drug‐resistant epilepsy
Authors: Lähde Niina , Basnyat Pabitra , Raitanen Jani , Lehtimäki Kai , Rosti‐Otajärvi Eija , Peltola Jukka 
Published: October 2023

AbstractObjectiveTo investigate executive functions and attention with repeated EpiTrack evaluations in a group of DR patients with drug‐resistant epilepsy (DRE) receiving vagus nerve stimulation (VNS) during a follow‐up duration of up to 5 years.MethodsThe study involved 33 patients with DRE who were assessed with EpiTrack as a part of the clinical VNS protocol. Evaluations were scheduled prior to VNS implantation and then at 6 months, 12 months, and yearly thereafter. However, the COVID‐19 pandemic disrupted follow‐up. Therefore, changes in EpiTrack total scores over time were analyzed using a linear mixed‐effects (LMEs) model to compensate for the variation in follow‐up duration when predicting EpiTrack total score changes over 5 years.ResultsThe median follow‐up time was 29 months. During each month, the EpiTrack total score was predicted to increase by 0.07 units (95% confidence interval [CI]: 0.01–0.12, P = 0.02), corresponding to a change from a baseline score of 27.3 (severe impairment) to a score of 28.9 (mild impairment) at 2 years and a score of 31.5 (almost normal) at 5 years. In the group of patients with psychiatric comorbidities, the EpiTrack total score increased by 0.14 units per month (P = 0.003), which was 3.5‐fold higher than the increase of patients without psychiatric comorbidities. For the patients taking 1–2 antiseizure medications (ASMs), the EpiTrack total score increased by 0.11 units per month (P = 0.005), which was almost quadruple the rate of patients taking 3–4 ASMs.SignificanceBased on EpiTrack total scores, the LME model predicted a four‐point improvement in executive functions among patients with DRE at 5 years after the initiation of VNS, representing a clinically meaningful change. DRE patients with comorbid depression seemed to experience the most cognitive benefits. In addition, better cognitive outcomes were achieved if the patient took less than three ASMs.Plain Language SummaryExecutive functions and attention may improve during vagus nerve stimulation therapy in patients with drug‐resistant epilepsy. Epilepsy patients who have depression or use fewer than three antiseizure medications are likely to benefit cognitively more from the treatment.
Closed‐form solution for natural frequency of flexible combined pile‐raft foundation
Authors: Bhaduri Aniruddha , Choudhury Deepankar 
Published: October 2023

AbstractDynamic attributes of flexible combined pile‐raft foundation (CPRF) hold paramount importance in assessing the behavior of it, especially in an earthquake prone area. The present study proposes a closed‐form solution for obtaining the natural frequency of flexible CPRF, where the piles and raft are represented as beam and thin plate respectively, lying on a two‐parameter Pasternak medium. Two simultaneous governing differential equations for the components are formulated and closed form solutions are obtained for finding the natural frequency and transient horizontal displacement of the foundation system. The complex soil‐structure interactions associated with the load‐bearing mechanism of CPRF is incorporated in the analysis scheme. The proposed method is validated with available centrifuge test result. Further parametric studies showcase that with decrease in raft thickness, the spectral acceleration response of the raft decreases. Also, for CPRF with high raft flexibility, the natural frequency of the foundation in dense sand is 34% and 53% higher compared to medium dense and loose sands, respectively. Thus, the present method can be reckoned as a notable contribution in comprehending the dynamic behavior of flexible CPRF.
Molecular imaging of tumour‐associated pathological biomarkers with smart nanoprobe: From “Seeing” to “Measuring”
Authors: Zhang Peisen , Li Wenyue , Liu Chuang , Qin Feng , Lu Yijie , Qin Meng , Hou Yi 
Published: October 2023

AbstractAlthough the extraordinary progress has been made in molecular biology, the prevention of cancer remains arduous. Most solid tumours exhibit both spatial and temporal heterogeneity, which is difficult to be mimicked in vitro. Additionally, the complex biochemical and immune features of tumour microenvironment significantly affect the tumour development. Molecular imaging aims at the exploitation of tumour‐associated molecules as specific targets of customized molecular probe, thereby generating image contrast of tumour markers, and offering opportunities to non‐invasively evaluate the pathological characteristics of tumours in vivo. Particularly, there are no “standard markers” as control in clinical imaging diagnosis of individuals, so the tumour pathological characteristics‐responsive nanoprobe‐based quantitative molecular imaging, which is able to visualize and determine the accurate content values of heterogeneous distribution of pathological molecules in solid tumours, can provide criteria for cancer diagnosis. In this context, a variety of “smart” quantitative molecular imaging nanoprobes have been designed, in order to provide feasible approaches to quantitatively visualize the tumour‐associated pathological molecules in vivo. This review summarizes the recent achievements in the designs of these nanoprobes, and highlights the state‐of‐the‐art technologies in quantitative imaging of tumour‐associated pathological molecules.
Alternative genetic alterations of MYC, BCL2, and/or BCL6 in high‐grade B‐cell lymphoma (HGBL) and diffuse large B‐cell lymphoma (DLBCL): Can we identify different prognostic subgroups?
Authors: Blomme Siska , De Paepe Pascale , Devos Helena , Emmerechts Jan , Snauwaert Sylvia , Cauwelier Barbara 
Published: October 2023

AbstractHigh‐grade B‐cell lymphoma (HGBL)/diffuse large B‐cell lymphoma (DLBCL) with rearrangements (R) in MYC and BCL2 and/or BCL6 are correlated with poor prognosis. Little is known about the impact of other genetic alterations (gain (G) or amplification (A)) of these genes. The aim of the study was to investigate whether we can identify new prognostic subgroups. Fluorescence in situ hybridization (FISH) results from 169 HGBL/DLBCL were retrospectively categorized into: (1) concurrent MYC‐R and BCL2‐R and/or BCL6‐R—samples with MYC‐R and BCL2‐R (+/− BCL6‐R); n = 21, and HGBL/DLBCL with MYC‐R and BCL6‐R; n = 11; (2) concurrent R and G/A in MYC and BCL2 and/or BCL6 called “alternative HGBL/DLBCL”—samples with (n = 16) or without (n = 6) BCL2 involvement; (3) BCL2 and/or BCL6 alterations without MYC involvement (n = 35); (4) concurrent G/A in MYC and BCL2 and/or BCL6 without R (n = 25); and (5) “No alterations” (n = 55). Patients with HGBL/DLBCL‐MYC/BCL2 and “alternative” HGBL/DLBCL (with BCL2 involvement) had significantly worse survival rates compared to the “no alterations” group. G/A of these genes in the absence of rearrangements did not show any prognostic significance. HGBL/DLBCL with MYC‐R and BCL6‐R without BCL2 involvement showed a better survival rate compared to HGBL/DLBCL‐MYC/BCL2. According to immunohistochemistry, “double/triple” expression (DEL/TEL) did not show a significantly worse outcome compared to absent DEL/TEL. This study highlights the continued value of FISH assessment of MYC, BCL2, and BCL6 in the initial evaluation of HGBL/DLBCL with different survival rates between several genetic subgroups.
Optimization of calcium carbide residue utilization for producing high‐quality calcium carbonate
Authors: Yang Yuhang , Li Wenxiu , Xun Zhiwei , Yi Zhenwei , Wang Tao , Yu Zitao , Huang Yan , Gu Yongzheng 
Published: October 2023

AbstractIn light of the current situation where the utilization of calcium carbide slag yields low profits but holds significant potential for reducing carbon emissions, ammonium acetate was employed to leach calcium carbide slag. It also played a crucial role in regulating the products of indirect carbon dioxide carbonation when mixed with glycine and lye. Ammonium acetate's significance underscores its dual role in both the leaching and carbonation processes. This process yielded calcium carbonate with particle sizes smaller than 100 nm, with a purity of 98% and a single vaterite phase. The calcium carbide residue demonstrated an impressive CO2 uptake rate of 23.5%. Ammonium acetate exhibited an efficiency of 79.2% as a leaching agent. The ammonium acetate method demonstrated enhanced environmental friendliness and facilitated a more efficient carbon uptake rate of 23.5% compared to conventional indirect methods. Furthermore, the addition of lye, glycine, and ammonium acetate effectively extended the nucleation time of the calcium carbonate crystals and induced the formation of more vaterite intermediates with smaller particle sizes. The influence mechanism of compound additives on the carbonation reaction was revealed through kinetic analysis and molecular dynamics. This innovative approach offers a promising avenue for simultaneously treating solid waste and reducing CO2 emission. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
Prediction of Reaction Performance by Machine Learning Using Streamlined Features: NMR Chemical Shifts as Familiar Descriptors
Authors: Song Su‐min , Eun Kim Ha , Woo Kim Hyun , Chung Won‐jin 
Published: October 2023

AbstractMachine learning (ML) has quickly emerged in synthetic organic chemistry to predict reaction outcomes such as yields and stereoselectivities. Notably, recent applications of the ML approach showed powerful performance in solving various chemical problems. However, the requirement of numerous descriptors and large datasets hampers the general use by non‐specialists. In this study, simple ML models were developed by utilizing easily available 13C‐NMR chemical shifts of the substrates as familiar descriptors to predict the site‐selectivity of geminal chlorofluorination of unsymmetrical 1,2‐dicarbonyl compounds. We identified that the feed‐forward neural network (FNN) model provides higher accuracy compared to other algorithms. Then, better prediction performance was acquired through streamlined models using minimal, only empirically relevant descriptors.
The evolving impact of engaging in leisure activities towards life quality: A longitudinal study of elderly in the UK
Authors: Aroean Lukman , Golgeci Ismail , Usrey Bryan 
Published: October 2023

AbstractWe examine the evolving impact of leisure activities (LA) on three key measures of the elderly's life quality: cognitive functioning (CF), psychological well‐being (PWB), and life enjoyment (LE). Using four waves of the English Longitudinal Studies of Ageing between 2008 and 2014 with 7097 respondents, we investigate how the elderly's LA influence their CF, PWB, and LE. Building on the theoretical perspective of being active in promoting psycho‐mental health, we confirm the positive impact of engaging in LA, such as going to the cinema/theatre and eating out, on the elderly's life quality. We further reveal the evolving impact of LA on the elderly's life quality. In a steady manner, LA directly promote the elderly's LE. In a declining pattern, CF and PWB mediate the relationships between LA and LE. As such, the impact of LA in sustaining perceived LE occurs dominantly as a direct effect during the activity. The elderly's LE throughout their old age can originate from engaging in LA, which mainly work directly rather than indirectly through CF and PWB.
Distribution Patterns and Habitat Characterization of Elmidae and Hydraenidae (Insecta: Coleoptera) in the Weidlingbach Near Vienna, Austria
Authors: Dietrich F. , Waringer J. A. 
Published: October 2023

AbstractA total of 870 adult and 831 larval Elmidae and Hydraenidae were caught from September 1995 to September 1996 at the Weidlingbach, a fourth order tributary of the Danube near Vienna, Austria, using a Heß sampler at 14 sampling stations from source to mouth. Elmis maugetii (Latreille) and Riolus subviolaceus (Müller) accounted for 66.3% of the total, whereas Hydraena gracilis (Germar) was the most abundant Hydraenidae species.Based on head width, instars 1–6 were collected in E. maugetii, instars 2–6 in R. subviolaceus and instars 3–6 in Limnius volckmari (Panzer) and Riolus cupreus (Müller); from the remaining species, only instars 4–6 were sampled.E. maugetii was most abundant on coarse, moss‐covered substrates (median = 22.2 mm) exposed to high water velocity (median = 69.4 cm/s; range = 6.0–117.6 cm/s); the latter was also true for R. subviolaceus although it favoured smaller sediment grain sizes (median = 10.7 mm). Sites exposed to only moderate flow and with abundant filiform algae were preferred by Esolus parallelepipedus (Müller) and L. volckmari, whereas the Hydraenidae species, Esolus angustatus (Müller), R. cupreus and Oulimnius tuberculatus (Müller) were collected mostly at sites with moderate current speed and abundant moss‐covered pebbles of various size.Species richness and population density increased from source to mouth. At the spring sampling site Elmidae and Hydraenidae were completely lacking.
An Incubator for the Simulation of a Fluctuating Light Climate in Studies of Planktonic Primary Productivity
Authors: Gervais Frank , Hintze Thomas , Behrendt Horst 
Published: October 2023

AbstractA laboratory system for the quantification of phytoplankton photosynthesis under fluctuating light climate conditions is described. It consists of 2 temperature‐controlled incubators with a variable light supply, an algal batch culture in incubation bottles with appropriate stirrers and a set of oxygen electrodes to monitor algal photosynthesis. By the rotation of special grey filters between the incubator and the light source, a regular up and down movement in the water column is simulated in up to 7 parallel bottles. Different ratios of euphotic depth to mixing depth and different velocities can be applied. Simultaneously, 8 bottles can be incubated under constant light. The system is demonstrated in experiments with Chlamydomonas sp. Further possibilities of application are proposed.
Laboratory Studies of Parasite Transmission Aspects between Hydrobia spp. (Gastropoda) and Corophium volutator (Amphipoda)
Authors: Meissner Karin , Bick Andreas 
Published: October 2023

AbstractAspects of parasite transmission between Hydrobia spp. and Corophium volutator, first and second intermediate host of digenetic trematodes, were investigated under laboratory conditions. H. ventrosa is used as an intermediate host by several trematode species. Under laboratory conditions the most frequently observed emergence from H. ventrosa was of cercariae of Maritrema subdolum. The number of cercariae shed per day varied considerably. It was observed that 30 cercariae on average and up to 450 cercariae at maximum can emerge from a single H. ventrosa per day. Cercarial production continued until the death of the snails. The life‐span of cercariae of the species M. subdolum decreased as the water temperature increased. It can be concluded that under natural conditions the cercariae, after emerging, have a maximum period of 1 day in which to seek out their second intermediate host C. volutator. Almost all specimens of C. volutator exposed to cercariae of the species M. subdolum died within the test period of 6 days. High average cercarial densities caused short life‐spans (<50 h), while at lower densities longer survival times were possible. For cercariae of other Trematoda species, we were unable to find any equally clear evidence of a reduction in the survival rate of C. volutator within the test period. Mortality of C volutator, and other effects of infestation, as observed in our experiment, can be assumed to be a result of the penetration process of the cercariae but they also can be attributed to the mesocercariae.
Spatial Distribution, Food and Activity of Gomphus pulchellus SELYS 1840 (Insecta; Odonata; Gomphidae) from a Still Water Habitat
Authors: Alzmann Norbert , Köhler Bernd , Maier Gerhard 
Published: October 2023

AbstractDistribution patterns of Gomphus pulchellus larvae in different sediments with different density of prey organisms were studied in the field in a small gravel pit lake in the south of Germany. Larval burrowing behaviour at different temperatures as well as food preference, consumption rates and activity were studied in laboratory experiments. In the study lake G. pulchellus larvae lived exclusively in places where macrophytes were present and in fine sediments (mean grain size <3 mm) with detritus cover. There was a significant positive correlation between larval density and density of food organisms suggesting that abundance of food is one of the determinants of larval distribution. In late autumn larvae migrated to deeper places probably to survive the winter. Low temperatures simulated in laboratory experiments did not induce larvae to burrow deeper. Larvae were always found in a sediment depth of 0.59–0.74 cm. Experiments with mixed prey showed that G. pulchellus larvae preferred tubificid worms and chironomid larvae over gammarids and ephemerid larvae. However, chironomid larvae which stayed in their tubes had a higher survival rate than those outside of tubes. Single‐prey experiments showed that G. pulchellus larvae can prey not only on benthic species but also on Daphnia from the open water. Functional‐response experiments showed that one G. pulchellus larva consumes a maximum of 2 to 3 tubificid worms or chironomid larvae per day, which corresponds to a maximum biomass (freshweight) of 5 to 30 mg per day. Video recordings of activity showed that G. pulchellus larvae cover long distances of up to 52 m per night on the substrate surface and that activity on the substrate surface started after midnight and ceased before sunrise. Consumption of Zooplankton prey and high activity above the substrate is interpreted as an adaptation of G. pulchellus larvae to the life in still water habitats.
Phytoplankton Community Structure in the Drainage Network of a Mediterranean River System (Aliakmon, Greece)
Authors: Montesanto Barbara , Tryfon Eleni 
Published: October 2023

AbstractPhytoplankton structure was studied in Aliakmon river basin in April (highflow) and September (lowflow) 1995 in 29 sampling sites. Abundance and biomass were generally low and ranged considerably between sites. Benthic diatoms contributed greatly to the suspended algal assemblages whereas trends of potamoplankton development were observed downstream. Limnoplankton and especially chlorophytes developed in the areas where lentic conditions prevailed. The nature of changes in phytoplankton seemed to be both longitudinal and temporal. Multivariate techniques revealed that areas with distinctive morphology, hydrology and anthropogenic inputs tended to have similar phytoplankton composition although no simple relation with physico‐chemical factors can be shown. Human impact was more obvious on phytoplankton at the lowflow period. Generally, discharge played a significant role to the structure of phytoplankton communities.
Seasonal Development and Morphological Variability of Cyclotella ocellata (Bacillariophyceae) in the Eutrophic Lake Dagow (Germany)
Authors: Schlegel Ines , Scheffler Wolfram 
Published: October 2023

AbstractThe development of Cyclotella ocellata Pantocsek was studied systematically in the eutrophic, dimictic hardwater Lake Dagow from March to October, 1994. Cyclotella ocellata was the most important centric diatom in the lake with a maximum cell density of 6 × 106 cells 1−1. The seasonal development, characterized by a spring and a summer maximum, is considered in relation to environmental factors and the succession of the phytoplankton community. The amount of Cyclotella ocellata biomass as a proportion of the total phytoplankton biomass varied from 0.5 to 35%. In addition, seasonal changes in cell size and feature associated with sexual reproduction of Cyclotella ocellata were documented. Light and electron microscopic investigations demonstrate an extremely wide range of morphological variability of this natural population.