bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance enhancement of wind power forecast model using novel pre‐processing strategy and hybrid optimization approach
Authors: Kumar Krishan , Prabhakar Priti , Verma Avnesh 
Published: December 2023

SummaryDue to the energy crisis and environmental concerns, wind power has seen a considerable increase in use over the past 10 years as a source of renewable energy. Since wind is intermittent and variable, it is obvious that as penetration levels rise, the influence of wind power generation on the electric power system must be considered. Wind power forecasting is essential because large‐scale wind power integration will make it more difficult to plan, operate, and control the power system. An accurate forecast is an efficient way to deal with the operational problems brought on by wind variability. To better utilize wind energy resources, it is essential to increase prediction accuracy. Frequently, the noise in the dataset causes the ramp events to be misclassified or overestimated. The main emphasis of this study is the pre‐processing of wind power data that produces precise time‐series data while reducing noise or artifact content and maintaining the swing feature of the original data. For this task, the data augmentation approach is proposed, where the augmented data (synthetic data) will be added up with the training data, in such a way as to make the strategy useful for real‐time applications. As the next step, the significant features, such as higher‐order statistical features and lower‐order statistical features are extracted. The extracted features act as the input to the recurrent neural network (RNN) classifier, the weights of which are tuned using the proposed honey badger crow (HBCro) optimization algorithm. The proposed HBCro optimization algorithm acts as the major contribution of the proposed model, and it is modeled with the integration of the concepts of the crow search optimization (CSO) algorithm and the honey badger optimization algorithm (HBA). The proposed system is simulated in MATLAB and the effectiveness of the proposed method is validated by comparison with other conventional methods in terms of Error measures. Furthermore, the developed HBCro‐based RNN obtained efficient performance in terms of MSE, MAE, RMSE, RMPSE, MAPE, MARE, MSRE, and RMSRE of 0.1578, 0.0442, 0.2102, 123.238, 124.72, 0.9944, 1.1799, and 1.0732, respectively.
T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation
Authors: Li Tushuai , Sun Wenxue , Zhu Shenglong , He Chengsheng , Chang Tong , Zhang Jie , Chen Yongquan 
Published: December 2023

AbstractT‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in the progression of T‐2 toxin‐stimulated podocyte injury. A metabolomics experiment is performed to assess metabolic responses to T‐2 toxin infection in human podocytes. Roles of protein O‐linked‐N‐acetylglucosaminylation (O‐GlcNAcylation) in regulating T‐2 toxin‐stimulated podocyte injury in mouse and podocyte models are assessed. O‐GlcNAc target proteins are recognized by mass spectrometry and co‐immunoprecipitation experiments. Moreover, histone acetylation and autophagy levels are measured. T‐2 toxin infection upregulates glucose transporter type 1 (GLUT1) expression and enhances hexosamine biosynthetic pathway in glomerular podocytes, resulting in a significant increase in β‐arrestin‐1 O‐GlcNAcylation. Decreasing β‐arrestin‐1 or O‐GlcNAc transferase (OGT) effectively prevents T‐2 toxin‐induced renal dysfunction and podocyte injury. Mechanistically, O‐GlcNAcylation of β‐arrestin‐1 stabilizes β‐arrestin‐1 to activate the mammalian target of rapamycin (mTOR) pathway as well as to inhibit autophagy during podocyte injury by promoting H4K16 acetylation. To sum up, OGT‐mediated β‐arrestin‐1 O‐GlcNAcylation is a vital regulator in the development of T‐2 toxin‐stimulated podocyte injury via activating the mTOR pathway to suppress autophagy. Targeting β‐arrestin‐1 or OGT can be a potential therapy for T‐2 toxin infection‐associated glomerular injury, especially podocyte injury.
Recommended Practices for More Accessible Quantification of Low‐Concentration Aqueous Phase Products in Photo/Electrocatalytic CO2/N2 Fixation
Authors: Li Dong , Xu Ning , Zhao Yunxuan , Shi Run , Zhou Chao , Zhang Li‐Ping , Zhang Tierui 
Published: December 2023

AbstractThe sustainable development of novel photo/electrocatalytic CO2/N2 fixation for chemical synthesis is predicated on reliable, accurate, and rapid detection methods. The directness, specificity, and simultaneity in detecting multiple molecules of the 1H nuclear magnetic resonance (1H‐NMR) technique have aroused increasing interest in photo/electrocatalysis. Thus far, two data processing means have been developed for the precise 1H‐NMR data processing: peak integral and peak height methods. However, few detailed studies offer a clear steer for choosing data processing methods for the concerned products in photo/electrocatalysis, especially the guidelines under the conditions of baseline distortions induced by water suppression. Herein, the feasible practices are restudied to quantify classical products in photo/electrocatalytic CO2/N2 fixation. On the basis of experimental results, 1H‐NMR data processing methods (peak integral and peak height methods) are found to convey different applicability for the different low‐concentration products, while introducing water suppression in the 1H‐NMR tests. The essential reason can be attributed to the baseline distortions caused by the water suppression, which arouses differentiated deviation of peaks with different peak widths. With this in mind, an accessible quantification criterion is provided to avoid superfluous input of time or cost in precise 1H‐NMR detection of low‐concentration products.
Ammonolysis of Glyoxal at the Air‐Water Nanodroplet Interface
Authors: Dong Zegang , Francisco Joseph S. , Long Bo 
Published: December 2023

AbstractThe reactions of glyoxal (CHO)2) with amines in cloud processes contribute to the formation of brown carbon and oligomer particles in the atmosphere. However, their molecular mechanisms remain unknown. Herein, we investigate the ammonolysis mechanisms of glyoxal with amines at the air‐water nanodroplet interface. We identified three and two distinct pathways for the ammonolysis of glyoxal with dimethylamine and methylamine by using metadynamics simulations at the air‐water nanodroplet interface, respectively. Notably, the stepwise pathways mediated by the water dimer for the reactions of glyoxal with dimethylamine and methylamine display the lowest free energy barriers of 3.6 and 4.9 kcal ⋅ mol−1, respectively. These results showed that the air‐water nanodroplet ammonolysis reactions of glyoxal with dimethylamine and methylamine were more feasible and occurred at faster rates than the corresponding gas phase ammonolysis, the OH+(CHO)2 reaction, and the aqueous phase reaction of glyoxal, leading to the dominant removal of glyoxal. Our results provide new and important insight into the reactions between carbonyl compounds and amines, which are crucial in forming nitrogen‐containing aerosol particles.
A single‐center retrospective analysis of prognoses in patients with melanoma brain metastases and effectiveness of treatment in Japan
Authors: Wada Shogo , Ogata Dai , Kashihara Tairo , Okuma Kae , Eto Hirofumi , Nakano Eiji , Takahashi Akira , Namikawa Kenjiro , Igaki Hiroshi , Yamazaki Naoya 
Published: December 2023

AbstractBackgroundMelanoma brain metastasis (MBM) has a poor prognosis, although recent treatments, including immune checkpoint inhibitors and targeted therapy, have improved the prognosis. However, these systemic therapies have been reported to be less efficient for Asian patients. We investigated the survival of Asian patients with MBM and the effectiveness of systemic therapies.MethodsWe retrospectively reviewed the survival rates of patients diagnosed with MBM between January 2011 and December 2021 at the National Cancer Center Hospital in Tokyo, Japan. In addition, we identified factors associated with survival using Cox regression analysis.ResultsA total of 135 patients were included. The median overall survival (OS) after an MBM diagnosis was 7.8 months (95% confidence interval [CI] 6.1–9.6). The 6‐month and 1‐year survival rates were 60.7% and 34.8%, respectively. We identified the prognostic factors of MBM, including non‐acral primary location, low serum LDH levels, systemic therapy of single‐agent immune checkpoint inhibitors (ICIs) or targeted therapies (TTs), and radiotherapy of stereotactic irradiation (STI). We found no significant difference in effectiveness between single‐agent ICIs, the combination of Nivolumab and Ipilimumab (COMBI‐ICI), and TTs (COMBI‐ICI vs. single‐agent ICI, hazard ratio 0.71, 95% confidence interval 0.27–1.88, p = 0.49; COMBI‐ICI vs. TT: hazard ratio 0.46, 95% confidence interval 0.14–1.55, p = 0.21).ConclusionsSystemic therapy and radiotherapy have improved the survival of MBM patients, but the survival of Asian patients remains poor. Our findings suggest that COMBI‐ICIs are not significantly more effective than single‐agent ICI or TT in treating MBM.
Perceptions of domestic and extra‐domestic environment during the COVID‐19 pandemic in an Italian representative sample
Authors: Faggiano Manuel , Donato Silvia , Parise Miriam , Pagani Ariela Francesca , Ferrari Laura , Ranieri Sonia , Canzi Elena , Danioni Francesca Vittoria , Barni Daniela , Lanz Margherita , Regalia Camillo , Rosnati Rosa Regina , Iafrate Raffaella 
Published: December 2023

AbstractPerception of domestic and extra‐domestic environment plays a key role in structuring reality, representing the boundary between private and public life. COVID‐19 pandemic led to changes both inside and outside domestic borders, modifying those reciprocal perceptions. The aim of this study was to assess perceptions of domestic and extra‐domestic environments after the first wave of COVID‐19 pandemic on a representative Italian sample, and how such perceptions were related to individuals' well‐being at individual, family and social levels. Participants filled an online self‐report questionnaire in July 2020. Cluster analyses were conducted on domestic and extra‐domestic environment perceptions, leading to the identification of four clusters. Clusters were compared in terms of sociodemographic characteristics, and individual, family and social factors. Identified clusters report different levels of well‐being at each level. The role of factors is identified, and possible implications are discussed. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Cytotoxic withanolides from the leaves of Datura stramonium L.
Authors: Pan Juan , Liu Yan , Li Xin‐Yuan , Wang Si‐Yi , Wu Jia‐Tong , Li Meng‐Meng , Guan Wei , Mohammed Algradi Adnan , Kuang Hai‐Xue , Yang Bing‐You 
Published: December 2023

AbstractSix novel withanolides, along with nine known related compounds were isolated from the leaves of Datura stramonium L. The structures and absolute configurations of the new withanolides were elucidated by employing various spectral techniques and comparing them with those previously reported in the literature. In addition, four withanlides demonstrated interesting cytotoxic activity on LN229 cells with IC50<20 μM.
A New Brominated Isocoumarin from the Marine Starfish‐Associated Fungus Aspergillus sp. WXF1904**
Authors: Li Chao , Lin Xiuping , Wang Shiwei , Guan Da , Wang Xiaofang , Yang Bin , Zhou Xuefeng , Li Jianfang , Xiong Bentao , Liu Yonghong , Sun Yanmei 
Published: December 2023

AbstractBased on the one strain many compounds strategy, a new brominated isocoumarin, 5‐bromo‐6,8‐dihydroxy‐3,7‐dimethylisocoumarin (1), along with four new natural products, methyl 3‐bromo‐2,4‐dihydroxy‐6‐methylbenzoate (2), methyl 2‐bromo‐4,6‐dihydroxybenzoate (3), (E)‐3‐(3‐bromo‐4‐hydroxyphenyl) acrylic acid (4) and 4‐hydroxy‐3‐methyl‐6‐phenyl‐2H‐pyran‐2‐one (5), and four known compounds, methyl orsellinate (6), 4‐hydroxy‐3‐methyl‐6‐(1‐methyl‐1‐propenyl)‐2H‐pyran‐2‐one (7), pilobolusate (8) and cis‐ferulic acid (9), were isolated from the ethyl acetate extract of the fungus Aspergillus sp. WXF1904 under the condition of adding bromine salt to the production medium. The structures of the new compounds were established by analysis of NMR and MS data. Compounds (1–9) were evaluated for inhibitory activity of acetylcholinesterase and pancreatic lipase, the new compound 1, known compounds 6 and 7 displayed weak inhibitory activity against acetylcholinesterase, compounds 2, 5, 7 and 8 showed weak inhibitory activity against pancreatic lipase.
Why do wealth advisors stay or leave their firms?
Authors: Mattia Mark J. , Mattia Laura , Timmerman Inga 
Published: December 2023

AbstractWe study the determinants associated with wealth advisors' consideration to leave or say at financial planning firms. Utilizing self‐determination theory as the foundational theoretical framework and focusing on the psychological aspect of the decision, we develop a structural equation model that defines the factors relating to work satisfaction, affective work commitment, and turnover intention in the wealth management profession. We provide evidence for the roles played by autonomous motivation, reward, and punishment in determining job retention and affective work commitment among wealth advisors in the United States. By showing the importance of autonomous motivation on retention, we are offering the wealth management industry one extra tool to influence employee retention.
Manipulating the corrosion homogeneity of aluminum anode toward long‐life rechargeable aluminum battery
Authors: Long Bo , Wu Feng , Li Yu , Yang Haoyi , Liu Wenhao , Li Ying , Li Qiaojun , Feng Xin , Bai Ying , Wu Chuan 
Published: December 2023

AbstractAluminum metal batteries are considered to be promising secondary batteries due to their high theoretical specific capacity. However, metallic aluminum suffers from corrosion, pulverization, and crushing problems in nonaqueous electrolytes. Constructing a solid‐electrolyte interphase layer on the anode electrode has been confirmed to be the key to improving the cycling performance of rechargeable batteries. Herein, we demonstrate an Al metal anode with a physical protective layer achieved by a simple blade coating method. This modified Al metal anode demonstrates ultra‐low voltage hysteresis (~25 mV at 0.1 mA cm−2 and ~30 mV at 1 mA cm−2), and superior stability (630 h at 0.1 mA cm−2 and 580 h at 1 mA cm−2). When coupling this anode with flake graphite cathode, the assembled full cells exhibit superior cycling stability (92 mAh g−1 maintained after 740 cycles at 0.1 A g−1). The current work presents a promising approach to stabilize Al metal anodes for next‐generation rechargeable aluminum batteries.
Looking back and looking forward: A scientometric analysis of the evolution of corporate sustainability research over 47 years
Authors: In Soh Young , Lee Young Joon , Eccles Robert G. 
Published: December 2023

AbstractThis study systematically reviews the evolutionary trajectory of corporate sustainability research spanning from 1973 to 2019. Through a scientometric analysis of 26,111 Web of Science articles, it demonstrates the continuous development of the conceptual foundations of corporate sustainability, leading to changes in research subjects over time. Despite recent efforts to integrate sustainability into mainstream business models, there remains a lack of consensus on theoretical and methodological frameworks. The study aims to enhance understanding of the conceptual foundations of corporate sustainability by classifying 47 years of research into four major periods: the Dawn of Diverse Ideas (1979–2005), the Rise of Conceptual Frameworks (2006–2011), the Era of Heterogeneity (2012–2015), and the Age of Stakeholder Engagement (2016–2019). The analysis examines the leading research subjects, theories, and perceptions of corporate sustainability in each period, providing a comprehensive review of the evolution of sustainability research. Moreover, the study introduces emerging concepts in the latest sustainability research and underscores the significance of academic research in addressing the current challenges practitioners face.
Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis
Authors: Ferreira Lisia Barros , Williams Keryn A , Best Giles , Haydinger Cameron D , Smith Justine R 
Published: December 2023

AbstractCharacterised by intraocular inflammation, non‐infectious uveitis includes a large group of autoimmune and autoinflammatory diseases that either involve the eye alone or have both ocular and systemic manifestations. When non‐infectious uveitis involves the posterior segment of the eye, specifically the retina, there is substantial risk of vision loss, often linked to breakdown of the inner blood‐retinal barrier. This barrier is formed by non‐fenestrated retinal vascular endothelial cells, reinforced by supporting cells that include pericytes, Müller cells and astrocytes. Across the published literature, a group of inflammatory cytokines stand out as prominent mediators of intraocular inflammation, with effects on the retinal endothelium that may contribute to breakdown of the inner blood‐retinal barrier, namely tumour necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, IL‐8, IL‐17 and chemokine C‐C motif ligand (CCL)2. This article reviews the function of each cytokine and discusses the evidence for their involvement in retinal endothelial barrier dysfunction in non‐infectious uveitis, including basic laboratory investigations, studies of ocular fluids collected from patients with non‐infectious uveitis, and results of clinical treatment trials. The review also outlines gaps in knowledge in this area. Understanding the disease processes at a molecular level can suggest treatment alternatives that are directed against appropriate biological targets to protect the posterior segment of eye and preserve vision in non‐infectious uveitis.
Beneath the Antarctic sea‐ice: Fine‐scale analysis of Weddell seal (Leptonychotes weddellii) behavior and predator–prey interactions, using micro‐sonar data in Terre Adélie
Authors: Antoine Adélie , Labrousse Sara , Goulet Pauline , Chevallay Mathilde , Laborie Joris , Picard Baptiste , Guinet Christophe , Nerini David , Charrassin Jean‐Benoît , Heerah Karine 
Published: December 2023

AbstractLactation is the most energy‐demanding event in mammals' reproduction. In pinnipeds, females are the only food providers to the young and have developed numerous behavioral and physiological lactation strategies, from capital‐breeding to income‐breeding. Lactating females' fine‐scale foraging strategy, and precise understanding of how females supplement their pup's needs as well as their own are important to understand the species' ecology and energetic balance. Polar pinnipeds, inhabiting extreme environments, are sensitive to climate change and variability, understanding their constraints and foraging strategy during lactation is therefore important. In 2019, three sonar tags were deployed on lactating Weddell seals in Terre Adélie (East Antarctica) for 7 days, to study fine‐scale predator–prey interactions. Feeding activity was mostly benthic, reduced, central‐placed, and spatially limited. Females spent most of their time hauled‐out. A total of 331 prey capture attempts (PrCAs) were recorded using triaxial acceleration data, with 125 prey identified on echograms (5 cm, acoustic size). All PrCAs occurred on the seafloor, shallower than usual records (mean depth of 88 m, vs 280 m after their molt). We also found that they only fed in three of the five identified dive shapes, during the ascent or throughout the dive. Half of the prey were reactive to the seal's approach, either leaving the seafloor, or escaping just above the seafloor, suggesting that the seals hunt by chasing them from the seabed. Seals continuously scanned the area during the approach phase, evoking opportunistic foraging. Our results provide additional evidence that Weddell seal forage during lactation, displaying a mix of capital‐breeding and income‐breeding strategies during this period of physiological stress. This work sheds light on previously unexplored aspects of their foraging behavior, such as shallow water environments, targeting benthic prey, generally focusing on single prey rather than schools, and evidence of visual scanning through observed head movements.
Outstanding issues in the study of antipredator defenses
Authors: Huang Yuqian , Caro Tim 
Published: December 2023

AbstractProtective defense mechanisms are well documented across the animal kingdom, but there are still examples of antipredator defenses that do not fit easily into the current conceptualization. They either fall within the intersection of multiple mechanisms or fail to fall neatly into pre‐existing categories. Here, using Endler's predatory sequence as a framework, we identify problematic examples of antipredator defenses, separating them into protective mechanisms that are difficult to classify and those which act sequentially depending on context. We then discuss three ways of improving underlying terminological and definitional problems: (1) issues with English and polysemy, (2) overlapping aspects of similar mechanisms, and (3) unclear definitions. By scrutinizing the literature, we disentangle several opaque areas in the study of protective defense mechanisms and highlight questions that require further research. An unclear conceptual framework for protective defense mechanisms can lead to misconceptions in understanding the costs and benefits of defenses displayed by animals, while interchangeable terminologies and ambiguous definitions can hinder communication in antipredator studies.
Harbor porpoise losing its edge: Genetic time series suggests a rapid population decline in Iberian waters over the last 30 years
Authors: Ben Chehida Yacine , Stelwagen Tjibbe , Hoekendijk Jeroen P. A. , Ferreira Marisa , Eira Catarina , Torres‐Pereira Andreia , Nicolau Lidia , Thumloup Julie , Fontaine Michael C. 
Published: December 2023

AbstractImpact of climate change is expected to be especially noticeable at the edges of a species' distribution, where they meet suboptimal habitat conditions. In Mauritania and Iberia, two genetically differentiated populations of harbor porpoises (Phocoena phocoena) form an ecotype adapted to local upwelling conditions and distinct from other ecotypes further north on the NE Atlantic continental shelf and in the Black Sea. By analyzing the evolution of mitochondrial genetic variation in the Iberian population between two temporal cohorts (1990–2002 vs. 2012–2015), we report a substantial decrease in genetic diversity. Phylogenetic analyses including neighboring populations identified two porpoises in southern Iberia carrying a divergent haplotype closely related to those from the Mauritanian population, yet forming a distinct lineage. This suggests that Iberian porpoises may not be as isolated as previously thought, indicating possible dispersion from Mauritania or an unknown population in between, but none from the northern ecotype. Demo‐genetic scenario testing by approximate Bayesian computation showed that the rapid decline in the Iberian mitochondrial diversity was not simply due to the genetic drift of a small population, but models support instead a substantial decline in effective population size, possibly resulting from environmental stochasticity, prey depletion, or acute fishery bycatches. These results illustrate the value of genetics time series to inform demographic trends and emphasize the urgent need for conservation measures to ensure the viability of this small harbor porpoise population in Iberian waters.