bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical Simulation of Gravity Flow in Sublevel Caving Based on Polyhedron DEM
Authors: Yi Changping , Johansson Daniel , Wimmer Matthias , Nordqvist Anders , Greberg Jenny , Miguel Carlota Rodriguez San 
Published: December 2023

AbstractThe gravity flow behavior of blasted ore and caved waste in sublevel caving (SLC) mines is complex. The shape of fragmented ore and caved waste is identified as one of the principal factors influencing the gravity flow of ore. To investigate the effect of the particle shapes on the gravity flow, a code was developed to generate polyhedral fragments in different shapes and divide them into internal elements. Then these fragments were imported in the LS-DYNA code to generate SLC models containing blasted ore and caved waste and model the extraction process. To model the non-continuous loading process, the gravity flow was considered to be an intermittent process by setting a switcher at the extraction point. The flow behavior of ore from the numerical modeling is in agreement with the experimental results. The cumulative dilution of ore by waste is up to around 30%, which agrees with the results of the field survey.
A framework for local-level economic evaluation to inform implementation decisions: health service interventions to prevent hospital-acquired hypoglycemia
Authors: Gray Jodi , Thynne Tilenka R. , Eaton Vaughn , Reade Brianna , Larcombe Rebecca , Baldacchino Linda , Gehlert Jessica , Hakendorf Paul , Karnon Jonathan ,   for the Southern Adelaide Local Health Network’s (SALHN) Hypoglycaemia Clinical Working Group
Published: December 2023

Abstract

Objectives
Published evidence on health service interventions should inform decision-making in local health services, but primary effectiveness studies and cost-effectiveness analyses are unlikely to reflect contexts other than those in which the evaluations were undertaken. A ten-step framework was developed and applied to use published evidence as the basis for local-level economic evaluations that estimate the expected costs and effects of new service intervention options in specific local contexts.

Methods
Working with a multidisciplinary group of local clinicians, the framework was applied to evaluate intervention options for preventing hospital-acquired hypoglycemia. The framework included: clinical audit and analyses of local health systems data to understand the local context and estimate baseline event rates; pragmatic literature review to identify evidence on relevant intervention options; expert elicitation to adjust published intervention effect estimates to reflect the local context; and modeling to synthesize and calibrate data derived from the disparate data sources.

Results
From forty-seven studies identified in the literature review, the working group selected three interventions for evaluation. The local-level economic evaluation generated estimates of intervention costs and a range of cost, capacity and patient outcome-related consequences, which informed working group recommendations to implement two of the interventions.

Conclusions
The applied framework for modeled local-level economic evaluation was valued by local stakeholders, in particular the structured, formal approach to identifying and interpreting published evidence alongside local data. Key methodological issues included the handling of alternative reported outcomes and the elicitation of the expected intervention effects in the local context.
The Economic Cost of Unpaid Care to the Public Finances: Inequalities in Welfare Benefits, Forgone Earnings-related Tax Revenue, and Health Service Utilisation
Authors: Cartagena-Farias Javiera , Brimblecombe Nicola 
Published: December 2023

Abstract
There is limited research on the effect of unpaid care on the public finances, and on the inequalities present when providing support to those with caring responsibilities. The aims of this research are to estimate the overall costs to the State of providing care, and to identify sub-groups of carers with relatively greater costs to the government who may need more support. We used waves eight to ten from the United Kingdom Household Longitudinal Survey and performed two-part Generalised Linear Models and Propensity Score Matching. We found that providing care is associated with excess and potentially avoidable costs to government in terms of forgone earnings-related tax revenue, welfare benefits, and health service use. Older carers have lower healthcare costs, indicating, perhaps, issues related to accessing to services due to their role (as they may neglect their own health, worry about safety and costs of public transport). Older carers were also found to have lower levels of welfare benefits, suggesting challenges associated with applying for support (such as navigating cumbersome application processes and stigma-related barriers).
Temporal and Spatial Pattern Change in Evapotranspiration Over the High Plains: The Impact of and Guide on Extensive Groundwater‐Fed Irrigation
Authors: Zeng Ruijie , Yao Chuncheng , Cai Ximing , Haacker Erin 
Published: December 2023

AbstractAquifer depletion due to extensive and intensive irrigation in the High Plains has threatened the environmental sustainability of the region. The change of crop evapotranspiration (ET), the major form of agriculture water consumption, presents a critical signature of hydrologic cycle change. This study evaluates the relative contributions of climate and groundwater‐fed irrigation to ET temporal and spatial pattern change over the High Plains Aquifer, one of the most severely depleted aquifers in the US. We developed a framework to extend the Budyko hypothesis to assess the impact of catchment storage change on long‐term ET. It is found that irrigation from groundwater pumping contributes more than half of the increase in ET (74.1 mm) from the period of 1940–1975 to 1976–2010, despite an increase of precipitation (35.0 mm) in the region. ET seasonal variance is decreased by the decline in precipitation variability (at −20.7 mm) and increase in irrigation (at +14.2 mm). As expected, irrigation decreases ET coefficient of variability (i.e., the ratio of standard deviation to mean). Spatially, we find that the human‐induced ET heterogeneity post‐1975 superimposes over the natural east‐to‐west gradient (in precipitation and ET) of this region. A correlation between the statistics (mean vs. coefficient of variation) on ET and crop yield provides promising signatures for understanding the coupled natural and human system of High Plains agriculture. Guides are discussed regarding how to handle the tradeoffs between agricultural development and natural resource sustainability under climate variability in the High Plains and other regions with similar conditions.
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
Authors: Sun Wenzhe , Ye Bing , Chen Siyue , Zeng Lian , Lu Hongwei , Wan Yizhou , Gao Qing , Chen Kaifang , Qu Yanzhen , Wu Bin , Lv Xiao , Guo Xiaodong 
Published: December 2023

AbstractThe skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals, which mediate bone metabolism and skeletal pain. In recent years, bone tissue engineering has increasingly focused on the effects of the nervous system on bone regeneration. Simultaneous regeneration of bone and nerves through the use of materials or by the enhancement of endogenous neurogenic repair signals has been proven to promote functional bone regeneration. Additionally, emerging information on the mechanisms of skeletal interoception and the central nervous system regulation of bone homeostasis provide an opportunity for advancing biomaterials. However, comprehensive reviews of this topic are lacking. Therefore, this review provides an overview of the relationship between nerves and bone regeneration, focusing on tissue engineering applications. We discuss novel regulatory mechanisms and explore innovative approaches based on nerve–bone interactions for bone regeneration. Finally, the challenges and future prospects of this field are briefly discussed.
Bio-inspired self-healing and anti-corrosion waterborne polyurethane coatings based on highly oriented graphene oxide
Authors: Wang Lin , Wang Xuebin , Liu Tong , Sun Fuyao , Li Suning , Geng Yuhao , Yao BoWen , Xu Jianhua , Fu JiaJun 
Published: December 2023

AbstractIn the face of ubiquitous corrosion threats, the development of high-performance elastomer protective materials with active self-healing functions is extremely challenging and significant. We propose an approach by combining WPU elastomer with GO to create the multifunctional pearl layer structured polymers with interface hydrogen bonds. By crosslinking the polycaprolactone diol (PCL) chain with a hydrogen bond array, the elastomer with high mechanical strength, extensibility, elasticity, excellent damage resistance, and healing properties was successfully synthesized. The elastomer exhibits remarkable mechanical properties, including a tensile strength of 39.89 MPa, toughness value of 300.3 MJ m−3, and fracture energy of 146.57 kJ m−2. The enhanced damage resistance of the elastomer can be attributed to the decomposable hydrogen bond array as well as the strain-induced crystallization of PCL fragments, which effectively dissipate energy. Importantly, due to the reversibility of the hydrogen bonding array, the fractured WPU can easily heal and restore its original mechanical properties when subjected to heating at 50 °C. Moreover, the photothermal properties of GO enable the biomimetic polymer coating to achieve damage recovery after being irradiated with NIR for 30 s. The obtained biomimetic coating exhibits a highly oriented lamellar structure, thereby greatly enhancing physical barrier performance and anti-corrosion performance. Electrochemical impedance spectroscopy (EIS) shows that the impedance modulus is one order of magnitude higher than that of the blank coating. Additionally, scanning vibrating electrode (SVET) confirmed that the self-healing performance and protection effect of the biomimetic coating in 3.5 wt% NaCl solution were also reliable. This highly reliable biomimetic coating presents a revolutionary solution for creating multi-functional, high-performance smart material in harsh environments.
Differentiating paranoia and conspiracy mentality using a network approach
Authors: Denecke Saskia , Schlier Björn , Kingston Jessica L. , Ellett Lyn , So Suzanne H. , Gaudiano Brandon A. , Morris Eric M. J. , Lincoln Tania M. 
Published: December 2023

AbstractAlthough mostly considered distinct, conspiracy mentality and paranoia share conceptual similarities (e.g., persecutory content, resistance to disconfirming evidence). Using self-report data from a large and multinational online sample (N = 2510; from the UK, the US, Hong Kong, Germany, and Australia), we examined whether paranoia and conspiracy mentality represent distinct latent constructs in exploratory and confirmatory factor analyses. Utilising network analysis, we then explored common and unique correlates of paranoia and conspiracy mentality while accounting for their shared variance. Across sites, paranoia and conspiracy mentality presented distinct, yet weakly correlated (r = 0.26), constructs. Both were associated with past traumatic experiences, holding negative beliefs about the self and other people, sleep problems, and a tendency to worry. However, paranoia was related to increased negative affect (i.e., anxiety) and decreased social support, whereas the opposite pattern was observed for conspiracy mentality (i.e., decreased anxiety and depression, increased social support). Paranoia and conspiracy mentality are related but not the same constructs. Their similar and distinct correlates point to common and unique risk factors and underlying mechanisms.
Acute hypoxia alters visuospatial attention orienting: an electrical neuroimaging study
Authors: Zani A. , Crotti N. , Marzorati M. , Senerchia A. , Proverbio A. M. 
Published: December 2023

AbstractOur study investigated the effects of hypoxia on visuospatial attention processing during preparation for a single/double-choice motor response. ERPs were recorded in two sessions in which participants breathed either ambient-air or oxygen-impoverished air. During each session, participants performed four cue-target attention orienting and/or alerting tasks. Replicating the classic findings of valid visuospatial attentional orienting modulation, ERPs to pre-target cues elicited both an Anterior directing attention negativity (ADAN)/CNV and a posterior Late directing attention positivity (LDAP)/TP, which in ambient air were larger for attention orienting than for alerting. Hypoxia increased the amplitude of both these potentials in the spatial orienting conditions for the upper visual hemifield, while, for the lower hemifield, it increased ADAN/CNV, but decreased LDAP/TP for the same attention conditions. To these ERP changes corresponded compensatory enhanced activation of right anterior cingulate cortex, left superior parietal lobule and frontal gyrus, as well as detrimental effects of hypoxia on behavioral overt performance. Together, these findings reveal for the first time, to our knowledge, that (1) these reversed alterations of the activation patterns during the time between cue and target occur at a larger extent in hypoxia than in air, and (2) acute normobaric hypoxia alters visuospatial attention orienting shifting in space.
Assessment of perfluoroalkyl substances concentration levels in wild bat guano samples
Authors: Gonkowski Slawomir , Martín Julia , Kortas Annemarie , Aparicio Irene , Santos Juan Luis , Alonso Esteban , Sobiech Przemysław , Rytel Liliana 
Published: December 2023

AbstractPerfluoroalkyl substances (PFASs) are substances commonly used in the production of various everyday objects, including among others kitchen dishes, cosmetics, or clothes. They penetrate to the environment and living organisms causing disturbances in the functioning of many internal organs and systems. Due to environmental pollution, wildlife is also exposed to PFASs, but the knowledge about this issue is rather limited. The aim of this study was to evaluate the exposure of wild greater mouse-eared bats (Myotis myotis), living in Poland, to six selected PFASs: five perfluoroalkyl carboxylic acids (perfluorobutanoic acid—PFBuA, perfluoropentanoic acid—PFPeA, perfluorohexanoic acid—PFHxA, perfluoroheptanoic acid—PFHpA, perfluorooctanoic acid—PFOA) and perfluorooctane sulfonic acid (PFOS) through the analysis of guano samples with liquid chromatography with tandem mass spectrometry (LC–MS–MS) method. To our knowledge this is the first study concerning the PFASs levels in bats, as well as using guano samples to evaluate the exposure of wild mammals to these substances. A total of 40 guano samples were collected from 4 bats summer (nursery) colonies located in various parts of Poland. The presence of PFASs mentioned were detected in all colonies studied, and concentration levels of these substances were sampling dependent. The highest concentration levels were observed in the case of PFPeA [1.34 and 3060 ng/g dry weight (dw)] and PFHxA (8.30–314 ng/g dw). This study confirms the exposure of wild bats to PFASs.
Monitoring of semiconductor manufacturing process on Bayesian AEWMA control chart under paired ranked set sampling schemes
Authors: Wang Yuzhen , Khan Imad , Noor-ul-Amin Muhammad , AlQahtani Salman A. , Ahmad Bakhtiyar 
Published: December 2023

AbstractQuality control often employs memory-type control charts, including the exponentially weighted moving average (EWMA) and Shewhart control charts, to identify shifts in the location parameter of a process. This article pioneers a new Bayesian Adaptive EWMA (AEWMA) control chart, built on diverse loss functions (LFs) such as the square error loss function (SELF) and the Linex loss function (LLF). The proposed chart aims to enhance the process of identifying small to moderate as well as significant shifts in the mean, signifying a notable advancement in the field of quality control. These are implemented utilizing an informative prior for both posterior and posterior predictive distributions, employing various paired ranked set sampling (PRSS) schemes. The effectiveness of the suggested chart is appraised using average run length (ARL) and the standard deviation of run length (SDRL). Monte Carlo simulations are employed to contrast the recommended approach against other control charts. The outcomes demonstrate the dignitary performance of the recommended chart in identifying out-of-control signals, especially applying PRSS designs, in comparison to simple random sampling (SRS). Finally, a practical application was conducted in the semiconductor manufacturing context to appraise the efficacy of the offered chart using various paired ranked set sampling strategies. The results reveal that the suggested control chart performed well in capturing the out-of-control signals far better than the already in use control charts. Overall, this study interposes a new technique with diverse LFs and PRSS designs, improving the precision and effectiveness in detecting process mean shifts, thereby contributing to advancements in quality control and process monitoring.
Nutritional impact of nano zeolite, probiotic, and fatty acids as feed additives on health status of Nile tilapia (Oreochromis niloticus)
Authors: Abd Elshafy Manar Bahaa , Abd EL-Monem Asmaa Ibrahim Mohamed , Khattab Ibrahim M. , Fadl Sabreen E. , Abou Khadiga Galal 
Published: December 2023

AbstractFor human consumption, fish is a good and affordable source of several crucial elements. Growing aquaculture management and output is always necessary. Therefore, this study was designed to evaluate the effect of probiotics, nano zeolite, and/or medium chain fatty acids (MCFA) on fish health and the chemical composition of the fish body. The experimental fish were distributed into eight groups. T1: Control group fed the basal diet without feed additives, T2: Nano zeolite at a rate of 2 mg/kg diet, T3: Pedococcus at a rate of 2 gm kg diet, T4: Medium chain fatty acids used according to produced company recommendation at a rate of 3.5 gm/kg diet, T5: Nano zeolite (2 mg/kg diet) + Pedococcus (2 mg/kg diet), T6: Nano zeolite (2 mg/kg diet) + Medium chain fatty acids (3.5 gm/kg diet), T7: Pedococcus (2 mg/kg diet) + Medium chain fatty acids (3.5 gm/kg diet), and T8: Nano zeolite (2 mg/kg diet) + Pedococcus (2 mg/kg diet) + Medium chain fatty acids (3.5 gm/kg diet). The obtained results showed an insignificant difference in the body composition of Nile tilapia fish fed feed additives alone or in combination. Moreover, the feed additives did not affect the health status of fish, as indicated by normal liver and kidney functions.
Divisively normalized neuronal processing of uncertain visual feedback for visuomotor learning
Authors: Makino Yuto , Hayashi Takuji , Nozaki Daichi 
Published: December 2023

AbstractWhen encountering a visual error during a reaching movement, the motor system improves the motor command for the subsequent trial. This improvement is impaired by visual error uncertainty, which is considered evidence that the motor system optimally estimates the error. However, how such statistical computation is accomplished remains unclear. Here, we propose an alternative scheme implemented with a divisive normalization (DN): the responses of neuronal elements are normalized by the summed activity of the population. This scheme assumes that when an uncertain visual error is provided by multiple cursors, the motor system processes the error conveyed by each cursor and integrates the information using DN. The DN model reproduced the patterns of learning response to 1-3 cursor errors and the impairment of learning response with visual error uncertainty. This study provides a new perspective on how the motor system updates motor commands according to uncertain visual error information.
Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways
Authors: Suyama Ritsuko , Cetraro Nicolas , Yew Joanne Y. , Kai Toshie 
Published: December 2023

AbstractReproduction is highly dependent on environmental and physiological factors including nutrition, mating stimuli and microbes. Among these factors, microbes facilitate vital functions for host animals such as nutritional intake, metabolic regulation, and enhancing fertility under poor nutrition conditions. However, detailed molecular mechanisms by which microbes control germline maturation, leading to reproduction, remain largely unknown. In this study, we show that environmental microbes exert a beneficial effect on Drosophila oogenesis by promoting germline stem cell (GSC) proliferation and subsequent egg maturation via acceleration of ovarian cell division and suppression of apoptosis. Moreover, insulin-related signaling is not required; rather, the ecdysone pathway is necessary for microbe-induced increase of GSCs and promotion of egg maturation, while juvenile hormone contributes only to increasing GSC numbers, suggesting that hormonal pathways are activated at different stages of oogenesis. Our findings reveal that environmental microbes can enhance host reproductivity by modulating host hormone release and promoting oogenesis.
Selectable diffusion direction with topologically protected edge modes
Authors: Funayama Keita , Hirotani Jun , Miura Atsushi , Tanaka Hiroya 
Published: December 2023

AbstractTopological insulators provide great potential to control diffusion phenomena as well as waves. In addition to the thermal localization and robust decay as reported, the topological edge states with higher degree of freedom offers a route to control directional diffusion. Here, we show that the direction of thermal diffusion can be selected by the contributions of the topologically protected edge modes in a honeycomb-shaped structure. Considering the thermal diffusion between the nearest neighboring sites of the honeycomb-shaped unit cells, the cells allow unidirectional heat balance from a macroscopic perspective when we set the structure to the temperature corresponding to the edge mode type. Moreover, this diffusion system is found to be immune to defects owing to the robustness of topological states. Our work points to exciting avenues for controlling diffusion phenomena.
Synthesizing 2h/e2 resistance plateau at the first Landau level confined in a quantum point contact
Authors: Fauzi Mohammad Hamzah , Nakagawara Keita , Hashimoto Katsushi , Shibata Naokazu , Hirayama Yoshiro 
Published: December 2023

AbstractA comprehensive understanding of quantum Hall edge transmission, especially a hole-conjugate of a Laughlin state such as a 2/3 state, is critical for advancing fundamental quantum Hall physics and enhancing the design of quantum Hall edge interferometry. In this study, we show a robust intermediate 2h/e2 resistance quantization in a quantum point contact (QPC) when the bulk is set at the fractional filling 2/3 quantum Hall state. Our results suggest the occurrence of two equilibration processes. First, the co-propagating 1/3 edges moving along a soft QPC arm confining potential fully equilibrate and act as a single 2/3 edge mode. Second, the 2/3 edge mode is further equilibrated with an integer 1 edge mode formed in the QPC. The complete mixing between them results in a diagonal resistance value quantized at 2h/e2. Similar processes occur for a bulk filling 5/3, leading to an intermediate (2/3)h/e2 resistance quantization. This finding highlights the importance of understanding the equilibration mechanisms that occur between different edge modes, offering insights into the processes of edge equilibration.