bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus
Authors: Fan Jing , Liu Pai , Zhao Kuan , Chen He-Ping 
Published: November 2023

AbstractThree previously undescribed compounds, cordycicadione (1), cordycicadin F (2), and 7-hydroxybassiatin (3), were isolated from the cultures of Cordyceps cicadae JXCH1, an entomopathogenic fungus. Their structures and relative configurations were elucidated primarily by NMR spectroscopic analysis. The absolute configurations of 1 and 2 were determined by ECD calculations. Single-crystal X-ray diffraction method was adopted to determine the absolute configuration of 3. Compound 2 is a polycyclic polyketide with an unusual enol ether moiety and a spiro ring. The compounds obtained in this study were subjected to screening their inhibition against the proliferation of the human lung cancer cell line A549 and the production of nitric oxide in murine macrophages RAW264.7.
Graphical Abstract
Interaktion, Feedback und Negotiation in serieller Fanfiction
Authors: Deckbar Anne 
Published: November 2023

ZusammenfassungFanfictions beziehen sich vor allem auf populäre Serien und sind Teil einer langen Tradition des Fandoms. Sie interpretieren und erweitern die jeweiligen Universen des Serienkanons. Fanfictions machen deutlich, welche Serien, insbesondere welche Charaktere oder Handlungen, hohe Aufmerksamkeit erhalten und besonders populär sind. Sie zeigen aber nicht nur an, welche Serien populär sind, sondern bilden auch einen Raum für Interaktion und Partizipation der Fans untereinander. Der vorliegende Beitrag befasst sich mit den Praktiken, Formen und Dynamiken der (sich dort bildenden) Partizipationskultur. Im Fokus der Analyse stehen exemplarische Beiträge der digitalen Plattform Wattpad. Die Prinzipien der seriell veröffentlichen Fanfictions, ihre Popularität sowie die unter diesen Voraussetzungen (Serialität, Popularität) etablierten Praktiken der online participatory culture können auf dieser Plattform besonders gut beobachtet werden, weil aufgrund der Metriken der Plattform Interaktion (z. B. in Form von Online-Kommentaren) und Popularitätsverteilungen (z. B. in Form von Rankings) messbar und nachvollziehbar sind. Als Korpus dienen digitale Fanfictions zu Superheld:innen des exzeptionell populären Marvel Fandoms.
On the geometric mechanics of assignment flows for metric data labeling
Authors: Savarino Fabrizio , Albers Peter , Schnörr Christoph 
Published: November 2023

AbstractMetric data labeling refers to the task of assigning one of multiple predefined labels to every given datapoint based on the metric distance between label and data. This assignment of labels typically takes place in a spatial or spatio-temporal context. Assignment flows are a class of dynamical models for metric data labeling that evolve on a basic statistical manifold, the so called assignment manifold, governed by a system of coupled replicator equations. In this paper we generalize the result of a recent paper for uncoupled replicator equations and adopting the viewpoint of geometric mechanics, relate assignment flows to critical points of an action functional via the associated Euler–Lagrange equation. We also show that not every assignment flow is a critical point and characterize precisely the class of coupled replicator equations fulfilling this relation, a condition that has been missing in recent related work. Finally, some consequences of this connection to Lagrangian mechanics are investigated including the fact that assignment flows are, up to initial conditions of measure zero, reparametrized geodesics of the so-called Jacobi metric.
Valorization of Air-Cooled EAF Manganese Slag in Comminution Processes: an Investigation into the Breakage Characterization
Authors: Suarez Laura , Jonsén Pär , Kajberg Jörgen 
Published: November 2023

AbstractIn recent years, slag, a residue from pyrometallurgical processes, has become more attractive in circular economy frameworks to increase the efficient use of resources throughout the life cycle of steel products and help in the reduction of carbon emissions. Its applicability is strongly dependent on the particle size, and therefore, the optimization of breaking processes should be approached by increasing the knowledge of the dynamics of slag to promote fracture. Increasing the knowledge on the mechanical response of manganese slag opens up the potential for the development of cost-effective numerical models, e.g., constitutive models based on inverse engineering calibration frameworks or digital twins. In this study, rate-dependent tests of manganese slag have been performed using a split Hopkinson pressure bar device for testing its dynamic mechanical response. In order to obtain information about the crack initiation and fracture process, 2D ultra-high speed imaging was implemented with a sampling frequency of 663,200 fps for diametrically loaded specimens. Full-field deformation measurements using digital image correlation (DIC) techniques showed a staggered fracture process where failure points on mechanical response curves vary due to the internal events happening in the material. Localized frictional occurrences and inertial effects acting inside the pre-cracked matrix have a strong effect on the global mechanical response, and therefore, a great variability of strengths was obtained.
Methodology for shape prediction and conversion of a conventional aerofoil to an inflatable baffled aerofoil
Authors: Mistri S.R. , Yerramalli C.S. , Pant R.S. , Guha A. 
Published: November 2023

AbstractInflatable wings for UAVs are useful where storage space is a severe constraint. Literature in the field of inflatable wings often assumes an inflated aerofoil shape for various analyses. However, the flexible inflatable aerofoil fabric might deform to another equilibrium shape upon inflation. Hence accurate shape prediction of the inflated aerofoil is vital. Further, no standardised nomenclature or a process to convert a smooth aerofoil into its corresponding inflatable aerofoil counterpart is available. This paper analytically predicts the equilibrium shape of any inflatable aerofoil and validates the analytical prediction using non-linear finite element methods. Further, a scheme for the generation of two types of inflatable aerofoils is presented. Parameters such as the number and position of compartments and aerofoil length ratio (ALR) are identified as necessary to define the aerofoil’s shape fully. A process to minimise the deviation of the inflatable aerofoil from its original smooth aerofoil using particle swarm optimisation (PSO) is discussed. Research presented in this paper can help in performing various analyses on the actual equilibrium shape of the aerofoil.
Monitoring the annual geodetic mass balance of Bordu and Sary-Tor glaciers using UAV data
Authors: Van Tricht Lander , Paice Chloë Marie , Rybak Oleg , Popovnin Victor , Satylkanov Rysbek , Huybrechts Philippe 
Published: November 2023

AbstractThe geodetic mass balance of a glacier corresponds to glacier-wide volume changes, converted to mass changes using density assumptions. It is typically calculated by differencing multi-temporal digital elevation models. In this study, we show how the annual geodetic mass balance of a glacier can be derived from uncrewed aerial vehicle (UAV) data. The presented workflow is applied to two small- to medium-sized glaciers in the Kyrgyz Tien Shan (Central Asia): Bordu glacier and Sary-Tor glacier. The obtained geodetic mass balance is compared with the glaciological mass balance derived from a network of ablation stakes and snow pits. A previously calibrated mass-balance model is used to correct for the difference in acquisition dates. The results show that the determined geodetic mass balance matches closely with the glaciological mass balance. Besides, for both glaciers the geodetic mass balance does not seem to be particularly sensitive to the assumptions regarding volume-to-mass conversion. Therefore, our results demonstrate that UAVs can serve as a valuable instrument to quantify the annual geodetic mass balance and to validate the glaciological mass balance. The conventional glaciological mass-balance estimation often relies on interpolation and extrapolation methods, whereas UAVs offer the potential for direct data acquisition over the entire glacier surface.
Bohr radius for Banach spaces on simply connected domains
Authors: Allu Vasudevarao , Halder Himadri 
Published: November 2023

AbstractLet$H^{\infty}(\Omega,X)$be the space of bounded analytic functions$f(z)=\sum_{n=0}^{\infty} x_{n}z^{n}$from a proper simply connected domain Ω containing the unit disk$\mathbb{D}:=\{z\in \mathbb{C}:|z| \lt 1\}$into a complex Banach spaceXwith$\left\lVert f\right\rVert_{H^{\infty}(\Omega,X)} \leq 1$. Let$\phi=\{\phi_{n}(r)\}_{n=0}^{\infty}$with$\phi_{0}(r)\leq 1$such that$\sum_{n=0}^{\infty} \phi_{n}(r)$converges locally uniformly with respect to$r \in [0,1)$. For$1\leq p,q \lt \infty$, we denote\begin{equation*} R_{p,q,\phi}(f,\Omega,X)= \sup \left\{r \geq 0: \left\lVert x_{0}\right\rVert^p \phi_{0}(r) + \left(\sum_{n=1}^{\infty} \left\lVert x_{n}\right\rVert\phi_{n}(r)\right)^q \leq \phi_{0}(r)\right\} \end{equation*}and define the Bohr radius associated withϕby\begin{equation*}R_{p,q,\phi}(\Omega,X)=\inf \left\{R_{p,q,\phi}(f,\Omega,X): \left\lVert f\right\rVert_{H^{\infty}(\Omega,X)} \leq 1\right\}.\end{equation*}In this article, we extensively study the Bohr radius$R_{p,q,\phi}(\Omega,X)$, whenXis an arbitrary Banach space, and$X=\mathcal{B}(\mathcal{H})$is the algebra of all bounded linear operators on a complex Hilbert space$\mathcal{H}$. Furthermore, we establish the Bohr inequality for the operator-valued Cesáro operator and Bernardi operator.
Determinants of incomplete childhood hepatitis B vaccination in Sierra Leone, Liberia, and Guinea: Analysis of national surveys (2018–2020)
Authors: Yendewa George A. , James Peter B. , Mohareb Amir , Barrie Umaru , Massaquoi Samuel P. E. , Yendewa Sahr A. , Ghazzawi Manal , Bockarie Tahir , Cummings Peterlyn E. , Diallo Ibrahima S. , Johnson Ambulai , Vohnm Benjamin , Babawo Lawrence S. , Deen Gibrilla F. , Kabba Mustapha , Sahr Foday , Lakoh Sulaiman , Salata Robert A. 
Published: November 2023

Abstract
Vaccination against hepatitis B virus (HBV) is effective at preventing vertical transmission. Sierra Leone, Liberia, and Guinea are hyperendemic West African countries; yet, childhood vaccination coverage is suboptimal, and the determinants of incomplete vaccination are poorly understood. We analyzed national survey data (2018–2020) of children aged 4–35 months to assess complete HBV vaccination (receiving 3 doses of the pentavalent vaccine) and incomplete vaccination (receiving <3 doses). Statistical analysis was conducted using the complex sample command in SPSS (version 28). Multivariate logistic regression was used to identify determinants of incomplete immunization. Overall, 11,181 mothers were analyzed (4,846 from Sierra Leone, 2,788 from Liberia, and 3,547 from Guinea). Sierra Leone had the highest HBV childhood vaccination coverage (70.3%), followed by Liberia (64.6%) and Guinea (39.3%). Within countries, HBV vaccination coverage varied by socioeconomic characteristics and healthcare access. In multivariate regression analysis, factors that were significantly associated with incomplete vaccination in at least one country included sex of the child, Muslim mothers, lower household wealth index, <4 antenatal visits, home delivery, and distance to health facility vaccination (all p < 0.05). Understanding and addressing modifiable determinants of incomplete vaccination will be essential to help achieve the 2030 viral hepatitis elimination goals.
Linguistic distance dynamically modulates the effects of bilingualism on executive performance in aging
Authors: Gallo Federico , Myachykov Andriy , Nelyubina Maria , Shtyrov Yury , Kubiak Joanna , Terekhina Liliia , Abutalebi Jubin 
Published: November 2023

AbstractTo better explain various neurocognitive consequences of bilingualism, recent investigations have adopted continuous measures of bilingual experience, as opposed to binary bi/monolingual distinctions. However, few studies have considered whether bilingualism's effects on cognition are modulated by the linguistic distance (LD) between L1 and L2, and none of the existing studies has examined cognitive consequences of LD in aging populations. Here, we investigated the modulatory role of LD on the relationship between bilingualism, executive performance, and cognitive reserve (CR) in a sample of senior bilinguals. Our results show a dynamic trajectory of LD effects, with more distant language pairs exerting maximum effects at initial stages of bilingual experience – and closer language pairs at advanced stages. Bilingualism-related CR effects emerged only in the individuals with closer language pairs, suggesting that the language control stage of bilingual experience may play a key role in CR accrual, as compared to the L2 learning stage.
Use of Open Access AI in teaching classical antiquity. A methodological proposal
Authors: Díaz-Sánchez Carlos , Chapinal-Heras Diego 
Published: November 2023

AbstractThe aim of this contribution is to present an innovative approach to the use of Open Access AI in teaching the Classical era at high school and university level. The paper first explains the growing interest in AI technology and its main applications in the subjects of philology, history and other related areas. The following sections show the different steps of the proposal, which uses the Midjourney program, as well as its pros and cons.
Multi‐Year Tracing of Spatial and Temporal Dynamics of Post‐Fire Aeolian Sediment Transport Using Rare Earth Elements Provide Insights Into Grassland Management
Authors: Burger William J. , Van Pelt R. Scott , Grandstaff David E. , Wang Guan , Sankey Temuulen T. , Li Junran , Sankey Joel B. , Ravi Sujith 
Published: November 2023

AbstractAeolian sediment transport occurs as a function of, and with feedback to ecosystem changes and disturbances. Many desert grasslands are undergoing rapid changes in vegetation, including the encroachment of woody plants, which alters fire regimes and in turn can change the spatial and temporal patterns of aeolian sediment transport. We investigated aeolian sediment transport and spatial distribution of sediment in the surface soil for 7 years following a prescribed fire using a multiple rare earth element (REE) tracer‐based approach in a shrub‐encroached desert grassland in the northern Chihuahuan desert. Results indicate that even though the aeolian horizontal sediment mass flux increased approximately three‐fold in the first windy season in the burned areas compared to control areas, there were no significant differences after three windy seasons. The soil surface of bare microsites was the major contributor of aeolian sediments in unburned areas (87%), while the shrub microsites contributed the least (<2%) during the observation period. However, after the prescribed fire, the contribution of aeolian sediments from shrub microsites increased considerably (∼40%), indicating post‐fire microsite‐scale sediment redistribution. The findings of this study, which is the first to use multiple REE tracers for multi‐year analysis of the spatial and temporal dynamics of aeolian sediment transport, illustrate how disturbance by prescribed fire can influence aeolian processes and alters dryland soil geomorphology in which distinct soils develop over time at very fine spatial scales of individual plants.
The Role of a Faunal Engineer, Geukensia demissa, in Modifying Carbon and Nitrogen Regulation Services in Salt Marshes
Authors: Williams Sydney L. , Rogers Jamie L. , Fischman Hallie S. , Morrison Elise S. , Angelini Christine 
Published: November 2023

AbstractInterest in leveraging suspension feeders, such as marine bivalves, to exert top‐down control on organic matter (OM) loading in estuaries is gaining momentum. Not only can these faunal engineers alleviate the consequences of nutrient pollution, but they may also bolster the critical blue carbon services provided by coastal ecosystems—a potential dual, mitigating effect on cultural eutrophication and climate change. Ribbed mussels, Geukensia demissa, offer a useful model for assessing faunally driven carbon (C) and nitrogen (N) processes in these systems and their relationships with faunal density. Combining bulk geochemical analyses with Bayesian stable isotope mixing model frameworks (MixSIAR), we quantified the effect of mussels on the source and amount of organic C and N deposited to the benthic floor (i.e., sedimentation), accumulated in surface sediments, and stored in aboveground Spartina alterniflora in Georgia salt marshes. Relative to areas without mussels, mussel presence shifted the source of deposited and accumulated OM to a more allochthonous makeup; amplified the amount of deposited, but not accumulated, allochthonous and autochthonous OM; and enhanced aboveground storage of C and N. Both sources of OM accumulated in sediments as well as standing stocks of C and N were highly and positively correlated with local mussel density (ind. m−2) but unrelated to neighboring mussel density (ind. ∼25 m−2) in adjacent, non‐mussel areas. This work provides new evidence that suspension feeders, through their faunal engineering activities, can interact powerfully and synergistically with primary producers to enhance the blue carbon services of marshes and counteract coastal eutrophication.
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy
Authors: Cui Donghai , Wang Zixiang , Dang Qianli , Wang Jing , Qin Junchao , Song Jianping , Zhai Xiangyu , Zhou Yachao , Zhao Ling , Lu Gang , Liu Hongbin , Liu Gang , Liu Runping , Shao Changshun , Zhang Xiyu , Liu Zhaojian 
Published: November 2023

AbstractRegulation of alternative splicing (AS) enables a single transcript to yield multiple isoforms that increase transcriptome and proteome diversity. Here, we report that spliceosome component Usp39 plays a role in the regulation of hepatocyte lipid homeostasis. We demonstrate that Usp39 expression is downregulated in hepatic tissues of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) subjects. Hepatocyte-specific Usp39 deletion in mice leads to increased lipid accumulation, spontaneous steatosis and impaired autophagy. Combined analysis of RNA immunoprecipitation (RIP-seq) and bulk RNA sequencing (RNA-seq) data reveals that Usp39 regulates AS of several autophagy-related genes. In particular, deletion of Usp39 results in alternative 5’ splice site selection of exon 6 in Heat shock transcription factor 1 (Hsf1) and consequently its reduced expression. Importantly, overexpression of Hsf1 could attenuate lipid accumulation caused by Usp39 deficiency. Taken together, our findings indicate that Usp39-mediated AS is required for sustaining autophagy and lipid homeostasis in the liver.
Structural basis for the toxicity of Legionella pneumophila effector SidH
Authors: Sharma Rahul , Adams Michael , Griffith-Jones Simonne , Sahr Tobias , Gomez-Valero Laura , Weis Felix , Hons Michael , Gharbi Sarah , Berkane Rayene , Stolz Alexandra , Buchrieser Carmen , Bhogaraju Sagar 
Published: November 2023

AbstractLegionella pneumophila (LP) secretes more than 300 effectors into the host cytosol to facilitate intracellular replication. One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when overexpressed in host cells. SidH is regulated by the LP metaeffector LubX which targets SidH for degradation in a temporal manner during LP infection. The mechanism underlying the toxicity of SidH and its role in LP infection are unknown. Here, we determined the cryo-EM structure of SidH at 2.7 Å revealing a unique alpha helical arrangement with no overall similarity to known protein structures. Surprisingly, purified SidH came bound to a E. coli EF-Tu/t-RNA/GTP ternary complex which could be modeled into the cryo-EM density. Mutation of residues disrupting the SidH-tRNA interface and SidH-EF-Tu interface abolish the toxicity of overexpressed SidH in human cells, a phenotype confirmed in infection of Acanthamoeba castellani. We also present the cryo-EM structure of SidH in complex with a U-box domain containing ubiquitin ligase LubX delineating the mechanism of regulation of SidH. Our data provide the basis for the toxicity of SidH and into its regulation by the metaeffector LubX.
Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma
Authors: Zhou Lin-Lin , Zhang Tao , Xue Yun , Yue Chuan , Pan Yihui , Wang Pengyu , Yang Teng , Li Meixia , Zhou Hu , Ding Kan , Gan Jianhua , Ji Hongbin , Yang Cai-Guang 
Published: November 2023

AbstractChemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However, we are currently unaware of any studies using selective and potent ClpP activators in lung squamous cell carcinoma. In this work, we report on such an activator, ZK53, which exhibits therapeutic effects on lung squamous cell carcinoma in vivo. The crystal structure of ZK53/ClpP complex reveals a π-π stacking effect that is essential for ligand binding selectively to the mitochondrial ClpP. ZK53 features on a simple scaffold, which is distinct from the activators with rigid scaffolds, such as acyldepsipeptides and imipridones. ZK53 treatment causes a decrease of the electron transport chain in a ClpP-dependent manner, which results in declined oxidative phosphorylation and ATP production in lung tumor cells. Mechanistically, ZK53 inhibits the adenoviral early region 2 binding factor targets and activates the ataxia-telangiectasia mutated-mediated DNA damage response, eventually triggering cell cycle arrest. Lastly, ZK53 exhibits therapeutic effects on lung squamous cell carcinoma cells in xenograft and autochthonous mouse models.
Asymmetric formal C–C bond insertion into aldehydes via copper-catalyzed diyne cyclization
Authors: Li Cui-Ting , Qi Lin-Jun , Liu Li-Gao , Ge Chang , Lu Xin , Ye Long-Wu , Zhou Bo 
Published: November 2023

AbstractThe formal C–C bond insertion into aldehydes is an attractive methodology for the assembly of homologated carbonyl compounds. However, the homologation of aldehydes has been limited to diazo approach and the enantioselective reaction was rarely developed. Herein, we report an asymmetric formal C–C bond insertion into aldehydes through diyne cyclization strategy. In the presence of Cu(I)/SaBOX catalyst, this method leads to the efficient construction of versatile axially chiral naphthylpyrroles in moderate to excellent yields with good to excellent enantioselectivities. This protocol represents a rare example of asymmetric formal C–C bond insertion into aldehydes using non-diazo approach. The combined experimental and computational mechanistic studies reveal the reaction mechanism, origin of regioselectivity and stereoselectivity. Notably, the chiral phosphine ligand derived from synthesized axially chiral skeleton was proven to be applicable to asymmetric catalysis.