bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct
Authors: Fascher Maximilian , Nowaczynski Sandra , Spindler Carolin , Strobach Tilo , Muehlhan Markus 
Published: November 2023

Abstract
Rationale
Substance use disorders (SUDs) rank among the most severely debilitating psychiatric conditions. Among others, decreased response inhibition capacities could make it more difficult for patients to abstain from drug use and maintain abstinence. However, meta-analyses on the neural basis of response inhibition in SUDs yielded conflicting results.

Objective
In this study, we revisited the neuroimaging research field and summarized the existing fMRI literature on overt response inhibition (Go/NoGo and stop-signal paradigms) across different SUDs.

Methods
We performed a systematic literature review and an activation likelihood estimation (ALE) meta-analysis to investigate the actual convergence of functional deviations observed in SUD samples. Results were further supplied by consecutive robustness measures and a post-hoc random-effects meta-analysis of behavioural data.

Results
We identified k = 21 eligible studies for our analysis. The ALE analysis indicated a significant cluster of convergence with its statistical peak in the right anterior insula. Consecutive analyses, however, indicated this result was not robust and susceptible towards publication bias. Additionally, a post-hoc random effects meta-analysis of the behavioural parameters of Go/NoGo and stop-signal paradigms reported by the included studies revealed no significant differences in task performance comparing SUD samples and controls.

Conclusion
We discuss that the role of task-based response inhibition may require some refinement as an overarching marker for SUD pathology. Finally, we give a few prospects for future research that should be further explored in this context.
Paving the way for new and challenging matrix reference materials—particle suspensions at the core of material processing providing RMs for method development and method validation
Authors: Emteborg Håkan , Seghers John , García-Ruiz Silvia , Elordui-Zapatarietxe Saioa , Breidbach Andreas , Labibes Kamel , Charoud-Got Jean , Koeber Robert 
Published: November 2023

AbstractSufficient homogeneity of the certified parameter(s) over the whole fill series of a matrix reference material (RM) is a fundamental quality criterion. In practice, the heterogeneity of the target parameter is evaluated, whereby a relative value can be calculated of how much the target parameter is varying over the RM-batch. A high degree of homogeneity (low heterogeneity) is an inherent quality mark of a good RM. Here, we report how challenging matrix RMs were produced by using particle suspensions at the core of the material processing step. The examples of matrix RMs produced span from whole water reference materials for persistent organic pollutants, PM2.5-like atmospheric dust certified for specific ions to microplastic RMs. Most of these RMs were subsequently used in different phases of analytical method development or for method validation. Common to all these matrices is that they cannot be easily mixed, handled, or dosed to prepare larger sample batches. In all cases, a continuously stirred suspension of particles was used during material processing. In general, relative between-bottle heterogeneities from 1.6 to 6% were achieved for the target parameters in these matrix presentations. Concerning developments of new CRMs in emerging fields, the co-dependence between the availability of validated analytical methods with good repeatability and testing materials with a known and high homogeneity of the target parameter(s) becomes particularly challenging. This situation is an RM/Method causality dilemma. To overcome that hurdle, strategies are proposed for stepwise processes where RM producers and a network of analytical method developers could work hand in hand. In addition, development of a portfolio of inexpensive and well-homogenised common samples coupled with a reporting interface is suggested. This would benefit method developers and RM producers alike. As more and more data is compiled for a specific matrix, it paves the way for new and challenging RMs that can later be used by a wider community.
National digital pathology projects in Switzerland: A 2023 update
Authors: Grobholz Rainer , Janowczyk Andrew , Frei Ana Leni , Kreutzfeldt Mario , Koelzer Viktor H. , Zlobec Inti 
Published: November 2023

AbstractThe Swiss Digital Pathology Consortium (SDiPath) was founded in 2018 as a working group of the Swiss Society for Pathology with the aim of networking, training, and promoting digital pathology (DP) at a national level. Since then, two national surveys have been carried out on the level of knowledge, dissemination, use, and needs in DP, which have resulted in clear fields of action. In addition to organizing symposia and workshops, national guidelines were drawn up and an initiative for a national DP platform actively codesigned. With the growing use of digital image processing and artificial intelligence tools, continuous monitoring, evaluation, and exchange of experiences will be pursued, along with best practices.
Association of central blood pressure with an exaggerated blood pressure response to exercise among elite athletes
Authors: Most Astrid , Kraushaar Lutz , Dörr Oliver , Keranov Stanislav , Hoelscher Sophie , Weber Rebecca , Akdogan Ebru , Groesser Vincent , Husain-Syed Faeq , Nef Holger , Hamm Christian W. , Bauer Pascal 
Published: November 2023

Abstract
Purpose
The systolic blood pressure/workload (SBP/MET) slope was recently reported to be a reliable parameter to identify an exaggerated blood pressure response (eBPR) in the normal population and in athletes. However, it is unclear whether an eBPR correlates with central blood pressure (CBP) and vascular function in elite athletes.

Methods
We examined 618 healthy male elite athletes (age 25.8 ± 5.1 years) of mixed sports with a standardized maximum exercise test. CBP and vascular function were measured non-invasively with a validated oscillometric device. The SBP/MET slope was calculated and the threshold for an eBPR was set at > 6.2 mmHg/MET. Two groups were defined according to ≤ 6.2 and > 6.2 mmHg/MET, and associations of CBP and vascular function with the SBP/MET slope were compared for each group.

Results
Athletes with an eBPR (n = 180, 29%) displayed a significantly higher systolic CBP (102.9 ± 7.5 vs. 100 ± 7.7 mmHg, p = 0.001) but a lower absolute (295 ± 58 vs. 384 ± 68 W, p < 0.001) and relative workload (3.14 ± 0.54 vs. 4.27 ± 1.1 W/kg, p < 0.001) compared with athletes with a normal SBP/MET slope (n = 438, 71%). Systolic CBP was positively associated with the SBP/MET slope (r = 0.243, p < 0.001). In multiple logistic regression analyses, systolic CBP (odds ratio [OR] 1.099, 95% confidence interval [CI] 1.045–1.155, p < 0.001) and left atrial volume index (LAVI) (OR 1.282, CI 1.095–1.501, p = 0.002) were independent predictors of an eBPR.

Conclusion
Systolic CBP and LAVI were independent predictors of an eBPR. An eBPR was further associated with a lower performance level, highlighting the influence of vascular function on the BPR and performance of male elite athletes.
Extracellular nitric oxide sustains root surface redox activity and growth under sudden flooding-induced hypoxic conditions in barley root tips
Authors: Zelinová Veronika , Demecsová Loriana , Liptáková Ľubica , Valentovičová Katarína , Tamás Ladislav 
Published: November 2023

Abstract
Main conclusion
Nitric oxide sustains root tip surface redox activity and restricts lipid peroxidation-triggered cell death in the root tips.

Abstract
In order to gain more insight into the involvement of nitric oxide (NO) in plant response to sudden flooding-induced hypoxic stress, we studied the effect of two NO donors, sodium nitroprusside and S-nitroso-L-glutathione, on short-term partial submergence-induced root growth inhibition, alteration in root surface redox activity, lipid peroxidation and cell death in two barley cultivars (cv.) at their early seedling stage. The short-term hypoxic stress induces root growth arrest in cv. Karmel, accompanied by increased lipid peroxidation and cell death. By contrast, in cv. Slaven, short-term hypoxic conditions cause only reduced root growth rate, associated with elevated extracellular NO level in the root tips. The root tip surface redox activity decreases with the increasing timespan of hypoxic conditions in both cultivars; however, this decrease in redox activity started earlier and was greater in the cv. Karmel in comparison with cv. Slaven. Application of NO donors during hypoxic stress sustains the root redox activity and eliminates the hypoxia-induced lipid peroxidation, accompanied by a partial restoration of root growth after short-term hypoxic stress. These results suggest that extracellular NO plays a key role in maintaining the root tip surface redox activity and in the restriction of lipid peroxidation and cell death under short-term hypoxic stress in the root tips of barley seedlings.
Influence of confining pressure on permeability and structural properties of selected sedimentary, igneous, and metamorphic rocks
Authors: Kudasik Mateusz , Anioł Łukasz , Gajda Aleksandra , Pajdak Anna 
Published: November 2023

AbstractAs part of the work, studies of the rock’s permeability to gases were carried out using the original measuring apparatus, which makes it possible to study gas seepage through a porous medium under confining pressure conditions corresponding to in situ. Samples of selected sandstone, sapropelic coal, marble, granite, limestone, and spongiolite rocks were used for permeability studies. The permeability of these rocks was determined in relation to helium (He) and carbon dioxide (CO2) in various values of the confining pressure: 1, 5, 10, 15, and 30 MPa. The obtained variability ranges of permeability coefficients allowed to assign the tested samples to particular classes, from poor and tight permeable rocks, where k∞ < 1 mD and k∞ < 0.1 mD (granite, marble), through good permeable rocks with a value of 10 < k∞ < 100 mD (limestone, spongiolite, sandstone), to very good permeable rocks with coefficient k∞ > 100 mD (coal). The Klinkenberg slippage effect was twice as large for He compared to CO2, and as permeability increased, the slippage effect disappeared. The Walsh model was used to analyze the obtained results, based on which it was found that the highest impact of effective stress was observed for a granite sample, the smallest for sapropelic coal, where an increase in effective stress by about 30 MPa reduced the permeability of coal to He by 50% and to CO2 by 30%. Changes in the structural properties of rocks as a result of subjecting them to gas seepage processes under confining pressure conditions were also examined. Open porosity, specific surface area, pore size distribution, and mean pore diameter in the samples were determined. In most of the studied rocks, a decrease in porosity and a reduction in the pore space of the rocks were observed after permeability tests under confining pressure conditions.
An Amundsen Sea source of decadal temperature changes on the Antarctic continental shelf
Authors: Drijfhout Sybren S. , Bull Christopher Y. S. , Hewitt Helene , Holland Paul R. , Jenkins Adrian , Mathiot Pierre , Garabato Alberto Naveira 
Published: November 2023

AbstractMass loss from the Antarctic Ice Sheet is dominated by basal melting–induced warm ocean water. Ice-sheet mass loss and thinning of buttressing ice shelves occur primarily in the Amundsen and Bellingshausen Seas. Here, we show that in a global ocean simulation using the 0.25° Nucleus for European Modeling of Ocean (NEMO) model driven by the JRA55 reanalysis from 1982 to 2017, the Amundsen sector of the Antarctic continental shelf acts as a gateway, regulating the on-shelf access of warm Circumpolar Deep Water (CDW) from the deep ocean and its westward transfer to other sectors up to ca. 90° E, particularly the Ross Sea. As a result, anomalies in Antarctic-shelf-averaged temperature mainly originate in the Amundsen sector. These changes are primarily governed by shifts in the Amundsen Sea Low associated with tropical climate variability, modulating the on-shelf transport of CDW via wind-driven perturbations to ocean currents. The ensuing temperature anomalies progress westward from the Amundsen Sea via three distinct routes: a slow, convoluted westward pathway on the shelf via the Antarctic Coastal Current; a faster westward pathway along the shelf break via the Antarctic Slope Current and then onto the shelf along topographic troughs; and a third, eastward route toward the Bellingshausen sector, whereby temperature anomalies are transported into a region of local wind-generated changes farther north. These results emphasize the importance of the Amundsen sector for climate variability over the Antarctic shelves.
On adsorption azeotropy and a classification based on the dual site Langmuir isotherm
Authors: Brandani Stefano 
Published: November 2023

AbstractAdsorption azeotropy is a phenomenon that has been known for nearly a century, yet few properties have been formally proven. Here four general properties of adsorption azeotropy in porous materials are discussed and shown to apply irrespective of the isotherm, including the fact that there is always a lower bound on the pressure at which an azeotrope may be present. As molecules of different size will favour the occurrence of an azeotrope, this study considers in detail the thermodynamically consistent dual site Langmuir model, where azeotropy is solely the result of the adsorbent heterogeneity. Six categories of adsorption azeotropes, which can be grouped into three pairs of mirror cases, are formally identified for this model. Dimensionless ratios allow to determine formally each category and the analysis also includes a discussion of the crossing of the pure component isotherms. The heterogeneity of the adsorbent is shown to lead to azeotropes that can include an upper bound on pressure; that can occur even if the pure component isotherms do not cross; and can be present below the pressure at which the pure component isotherms cross. Finally, the analysis allows to identify also the ranges of parameters for which the pure component isotherms cross but an azeotrope is not present.
Effect of a microbial phytase on the growth performance, digestibility and retention in a high plant meal inclusion diet for Atlantic salmon (Salmo salar)
Authors: Terrey David Edward , Braidi Daniel Arana , Serwata Robert 
Published: November 2023

AbstractThe effect of supplementation of a novel phytase (OptiPhos®; Huvepharma; 750 OTU) to high plant meal inclusion diets for Atlantic salmon (Salmo salar) was assessed. Diets were prepared without phytase, with phytase and with supplemental inorganic phosphorus (MCP). After 61 days significant increases in growth, FCR and protein efficiency were seen in diets supplemented with phytase and with MCP over the negative control (P < 0.05). Addition of phytase significantly increased digestibility of phytate and phosphorus (P) as well as retention over other diets (P < 0.05). Phytase addition significantly decreased faecal P losses while increasing metabolic loss over the negative control (P < 0.05). Addition of MCP showed significant increases in metabolic P loss (P < 0.05). In conclusion, the addition of phytase (OptiPhos®; Huvepharma) resulted in performance improvements comparable to inorganic P dosing, while significantly improving the reduction of effluent wastes from plant meal-based diets.
Seismic risk assessment of residential buildings by the Heuristic vulnerability model: influence of fragility curve models and inventory scale
Authors: Colajanni Piero , D’Anna Jennifer 
Published: November 2023

AbstractTypological-observational methods still constitute one of the most commonly applied tools for evaluation of the seismic risk and vulnerability of the existing building stock. Their efficiency is mainly related to the effectiveness of the procedure for deriving fragility curves, and the reliability and completeness of the database that describes the building stock. This paper presents a comparison between the vulnerability and damage distribution assessment provided by fragility curves used in the Macroseismic and Heuristic methods, and a comparison of exposure evaluation methodologies according to two different approaches, namely a compartment- and a building-scale survey. An application to the case study of the residential building stock in the historic center of Alcamo, a town of 45,000 inhabitants in Western Sicily (Italy), shows the major reduction in fragility provided by recalibration of the masonry buildings’ ductility values that characterize the Heuristic method. Moreover, the efficiency of the compartment scale survey approach, based on the CARTIS typological-structural characterization method of ordinary buildings in urban areas, is underlined.
Fast satellite DNA evolution in Nothobranchius annual killifishes
Authors: Voleníková Anna , Lukšíková Karolína , Mora Pablo , Pavlica Tomáš , Altmanová Marie , Štundlová Jana , Pelikánová Šárka , Simanovsky Sergey A. , Jankásek Marek , Reichard Martin , Nguyen Petr , Sember Alexandr 
Published: November 2023

AbstractSatellite DNA (satDNA) is a rapidly evolving class of tandem repeats, with some monomers being involved in centromere organization and function. To identify repeats associated with (peri)centromeric regions, we investigated satDNA across Southern and Coastal clades of African annual killifishes of the genus Nothobranchius. Molecular cytogenetic and bioinformatic analyses revealed that two previously identified satellites, designated here as NkadSat01-77 and NfurSat01-348, are associated with (peri)centromeres only in one lineage of the Southern clade. NfurSat01-348 was, however, additionally detected outside centromeres in three members of the Coastal clade. We also identified a novel satDNA, NrubSat01-48, associated with (peri)centromeres in N. foerschi, N. guentheri, and N. rubripinnis. Our findings revealed fast turnover of satDNA associated with (peri)centromeres and different trends in their evolution in two clades of the genus Nothobranchius.
Investing in Your Alumni: Endowments’ Investment Choices in Private Equity
Authors: Füss Roland , Morkoetter Stefan , Oliveira Maria 
Published: November 2023

AbstractWe investigate the role of alumni ties in university endowments’ decision to invest into private equity funds. Based on a sample of 1,590 commitments made by 189 U.S. endowments into 613 funds during the period of 1995 to 2017, we show that endowments are more likely to invest into funds that are managed by the alumni of their own alma mater. This finding is more pronounced for less prestigious and less private equity experienced university endowments. Thus, our results are not only dominated by institutions with a larger proportion of active alumni in the private equity industry. Furthermore, we observe that alumni ties are not associated with better performance compared to other endowment investments where such a tie does not exist.
Combined effects of water salinity and ammonia exposure on the antioxidative status, serum biochemistry, and immunity of Nile tilapia (Oreochromis niloticus)
Authors: Dawood Mahmoud A. O. , Gewaily Mahmoud , Sewilam Hani 
Published: November 2023

AbstractGrowing Nile tilapia in brackish water showed promising results, but the possibility of ammonia exposure can interrupt health status and productivity. Herein, the study tested the combined effects of water salinity and ammonia exposure on the antioxidative status, serum biochemistry, and immunity of Nile tilapia. Fish were assigned to eight groups where fish were reared in saline water (5, 10, and 15 ppt) with continuous or intermittent (every 3 days) total ammonia (TAN) exposure (5 mg TAN/L) (2 × 4 factorial design). After 30 days, the water salinity, TAN, and their interaction were markedly (P < 0.05), affecting the growth performance (final weight, weight gain, and specific growth rate) and survival rate of Nile tilapia. The growth performance and survival rate were markedly lower in tilapia grown in 15 ppt with continuous TAN exposure than in the remaining groups. The results showed that fish exposed to higher salinity levels (10 and 15 ppt) and continuous TAN exposure had a more robust antioxidative response, as evidenced by higher superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities and lower malondialdehyde (MDA) levels in the homogenates of the gills, intestines, and livers. The gills were notably affected, with congestion of primary filaments blood vessels and degeneration or shedding of secondary filaments epithelium, especially at salinity levels of 10 and 15 ppt. Additionally, the intestines displayed hyperplasia and inflammatory cell infiltration of intestinal mucosa at 5–10 ppt salinity, degeneration and sloughing of the intestinal epithelium at 15 ppt saline water, and increased goblet cell number at salinity of 10 ppt. The study found that continuous TAN exposure had a more significant impact on the fish, especially at higher salinity levels. Water salinity, TAN, and their interaction significantly affected all measured blood bio-indicators (total, albumin, globulin, ALT, AST, creatinine, urea, glucose, and cortisol levels). The phagocytic activity and index were markedly lowered in fish reared in 15 ppt with continuous TAN exposure, while the lysozyme activity was decreased in fish grown in 5, 10, and 15 ppt with continuous TAN exposure. In conclusion, Nile tilapia showed the possibility of growth with normal health status in brackish water (5–10 ppt); however, continuous TAN exposure can impair the productivity of tilapia, especially with high salinity (15 ppt).
COVID-19 in the neighbourhood: the socio-spatial selectivity of severe COVID-19 cases in Sweden, March 2020–June 2021
Authors: Kawalerowicz Juta , Cederström Agneta , Andersson Eva , Malmberg Bo 
Published: November 2023

AbstractIn this paper we analyse spatial and temporal variation in the risk of intensive care unit (ICU) admission for COVID-19 in Sweden. The analysis is based on geocoded and time-stamped data from the Swedish Intensive Care Registry (SIR). We merge this data with a classification of Swedish neighbourhood cluster types constructed from multi-scalar measures of socio-economic and country of birth segregation (Kawalerowicz and Malmberg in Multiscalar typology of residential areas in Sweden, 2021 available from https://doi.org/10.17045/sthlmuni.14753826.v1). We examine 1) if residence in more socio-economically deprived or diverse neighbourhood cluster types was associated with a higher risk of ICU admission for COVID-19, 2) if residence in more affluent neighbourhoods was associated with a lower risk of ICU admission for COVID-19, and 3) how these patterns changed over time during the three first waves of the pandemic. While the highest overall risk was associated with residence in urban disadvantage coupled with diversity, models where neighbourhood cluster types were interacted with waves reveal that the highest risk was associated with living in a neighbourhood cluster type characterised by rural town disadvantage coupled with diversity under the 3rd wave (February 2021–June 2021). Residence in such a neighbourhood cluster type was associated with a four times higher risk of ICU admission, compared to the reference category of living in a homogeneous rural neighbourhood cluster type with average levels of deprivation under wave 1. Looking at disparities within each wave we found that residence in most affluent urban areas was at first associated with a slightly higher risk of ICU admission for COVID-19 as compared with the reference category of living in a homogeneous rural neighbourhood cluster type, but under waves 2 and 3 this risk was no longer statistically significant. The largest inequalities between different neighbourhood cluster types could be seen during the 1st wave. Over time, the risks converged between different neighbourhood cluster types.