bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive meta-analysis of transcriptome data to identify signature genes associated with pancreatic ductal adenocarcinoma
Authors: Kordshouli Shirin Omidvar , Tahmasebi Ahmad , Moghadam Ali , Ramezani Amin , Niazi Ali 
Published: February 2024

Purpose
Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of less than 5%. Absence of symptoms at primary tumor stages, as well as high aggressiveness of the tumor can lead to high mortality in cancer patients. Most patients are recognized at the advanced or metastatic stage without surgical symptom, because of the lack of reliable early diagnostic biomarkers. The objective of this work was to identify potential cancer biomarkers by integrating transcriptome data.

Methods
Several transcriptomic datasets comprising of 11 microarrays were retrieved from the GEO database. After pre-processing, a meta-analysis was applied to identify differentially expressed genes (DEGs) between tumor and nontumor samples for datasets. Next, co-expression analysis, functional enrichment and survival analyses were used to determine the functional properties of DEGs and identify potential prognostic biomarkers. In addition, some regulatory factors involved in PDAC including transcription factors (TFs), protein kinases (PKs), and miRNAs were identified.

Results
After applying meta-analysis, 1074 DEGs including 539 down- and 535 up-regulated genes were identified. Pathway enrichment analyzes using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) revealed that DEGs were significantly enriched in the HIF-1 signaling pathway and focal adhesion. The results also showed that some of the DEGs were assigned to TFs that belonged to 23 conserved families. Sixty-four PKs were identified among the DEGs that showed the CAMK family was the most abundant group. Moreover, investigation of corresponding upstream regions of DEGs identified 11 conserved sequence motifs. Furthermore, weighted gene co-expression network analysis (WGCNA) identified 8 modules, more of them were significantly enriched in Ras signaling, p53 signaling, MAPK signaling pathways. In addition, several hubs in modules were identified, including EMP1, EVL, ELP5, DEF8, MTERF4, GLUP1, CAPN1, IGF1R, HSD17B14, TOM1L2 and RAB11FIP3. According to survival analysis, it was identified that the expression levels of two genes, EMP1 and RAB11FIP3 are related to prognosis.

Conclusion
We identified several genes critical for PDAC based on meta-analysis and system biology approach. These genes may serve as potential targets for the treatment and prognosis of PDAC.
PBX3 as a biomarker for the early diagnosis and prediction of prognosis of glioma
Authors: pan Cuicui , bai Xueli , Li Na , Zheng Ni , Si Yuanquan , Zhao Yueran 
Published: February 2024

Background
Increasing evidence have elucidated that PBX3 played a crucial role in cancer initiation and progression. PBX3 was differentially expressed in many cancer types. However, PBX3 potential involvement in gliomas remains to be explored.

Methods
The expression level of PBX3 in glioma tissues and glioma cells, and its correlation with clinical features were analyzed by data from TCGA, GEPIA, CGGA and CCLE. Univariable survival and Multivariate Cox analysis was used to compare several clinical characteristics with survival. We also analyzed the correlation between PBX3 expression level and survival outcome and survival time of LGG and GBM patients by using linear regression equation. GSEA was used to generate an ordered list of all genes related to PBX3 expression and screening of genes co-expressed with PBX3 mRNA by "limma" package.

Results
The results showed that PBX3 was highly expressed in gliomas and its expression increased with the increase of malignancy. Survival analysis found that PBX3 is more valuable in predicting the OS and PFI of LGG patients than that of GBM. For further study, TCGA and CGGA data were downloaded for univariate Cox analysis and multivariate Cox analysis which showed that the expression of PBX3 was independent influencing factors for poor prognosis of LGG patients. Meanwhile, Receiver operating characteristic (ROC) curve showed that PBX3 was a predictor of overall survival rate and progression-free survival rate of LGG. Linear regression model analysis indicated that the higher expression of PBX3 the higher the risk of death of LGG patients, and the higher expression of PBX3 the higher the risk of disease progression of LGG patients. Next, TCGA data were downloaded for GSEA and Co-expression analyses, which was performed to study the function of PBX3.

Conclusion
PBX3 may be involved in the occurrence and development of glioma, and has potential reference value for the early diagnosis and prediction of prognosis of glioma.
Medication abortion during the COVID-19 pandemic in France: A research based on the French national health insurance database
Authors: Chaput Justine , Becquet Valentine , Bithorel Pierre-Louis , Baril Elodie , de La Rochebrochard Elise , Mazuy Magali 
Published: February 2024

Objectives
During the COVID-19 pandemic in France, abortion was recognized as an essential service that cannot be delayed, and such care was therefore presumed to be maintained. The aim is to analyze the changes in the practice of abortion in 2020 to identify the consequences of the two lockdowns and the effects of the extension of the legal time limit.

Methods
We analyzed the data collected by the French national health insurance system, which covers 99% of the population. All women who had an elective abortion, either surgical or with medication, in France in 2019 and 2020 were included in the study. Trend changes in abortions were analyzed by comparing the ratio of the weekly number of abortions in 2020 with the weekly number in 2019.

Results
Both 2020 lockdowns were followed by a drop in abortions, particularly after the first and stricter lockdown. This may be explained not by an abrupt shutdown of access to abortion services, but rather by a decrease in conceptions during the lockdown weeks. The decrease was more marked for surgical abortions than for medication abortions in a hospital setting, and less so for medication abortions in non-hospital settings. Moreover, the proportion of the latter type of abortions continued to increase, showing the reinforcement of a previous trend.

Conclusions
Our findings indicate that expanding the legal time limit for abortion, diversifying the settings where abortions can be performed and the range of abortion providers help to facilitate access to this fundamental reproductive care.
IMPACT OF A HEALTHY WORKING ENVIRONMENT ON CARPET WEAVING INDUSTRY GROWTH
Authors: Haidari M. M. F. , Gul A. S. , Bobrovskaya T. V. , Kuzina E. V. 
Published: February 2024

The art of carpet weaving is an area of culture which development traces back to a century-old tradition in the countries of the East. This industry has survived to present day and plays a significant role for the economies of Central Asia and Iran, making up a large share of their export supplies. The scientists from different countries study the history of carpet weaving goods in the context of their cultural and artistic peculiarities: ornaments, signs, symbols, etc. However, this industry is primary considered as a source of creating objects of decorative and applied art. Only a few researchers address the current economic problems of the industry, in particular, the issues of labour organization and working conditions.
Technology and organization of handmade carpet making and working conditions of craftsmen in Afghanistan have not changed much for many centuries: one carpet is created within 2-4 months by backbreaking work of a group of 3-5 Afghan craftswomen. The industry faces significant competition from cheap artificial carpets from Pakistan. Experts note a drop in the export potential of carpet weaving in Afghanistan, and some even talk about the problem of fading of the ancient craft traditions in the country. These circumstances determined the relevance of the topic.
The article describes the findings of the fieldwork-based research devoted to investigating the impact of a healthy working environment on the carpet weaving industry growth. The aim of this study is to identify the factors affecting a healthy working environment and establish the correlation between them on the example of carpet weaving industry.
The findings are the results of the survey conducted in all carpet weaving companies in the Akchakh district of Jawzjan province in northern Afghanistan. This rural region has an ancient tradition of carpet weaving.
Pericardiectomy and Mechanical Mitro-Aortic Valve Replacement in a Young Patient With Erdheim-Chester Disease
Authors: Perez Nerea Lopez , Steenberghe Mathieu van , Seebach Jörg D. , Meyer Philippe , Lobrinus Johannes Alexander , Huber Christoph , Cikirikcioglu Mustafa 
Published: February 2024

Abstract
Erdheim-Chester disease is a rare histiocytosis that primarily affects the skeletal system, but cardiovascular manifestations occur in 75% of cases and are associated with a poor prognosis. Given the small number of cases, the evolution and management of the disease are uncertain. Therefore, it is important to report and share Erdheim-Chester cases. This report presents the case of a young patient with constrictive pericarditis and mitral valve regurgitation resulting from Erdheim-Chester disease.
PELAKSANAAN TUGAS BADAN PENANGGULANGAN BENCANA DAERAH KOTA SEMARANG BERDASARKAN PERATURAN DAERAH NOMOR 12 TAHUN 2010 TENTANG ORGANISASI DAN TATA KERJA BADAN PENANGGULANGAN BENCANA DAERAH KOTA SEMARANG
Authors: Zulqa Ihdaa , Herawati Ratna , Hardjanto Untung Sri 
Published: February 2024

Kota Semarang secara geografis terbagi menjadi dua bagian yaitu, Semarang atas dibagian selatan yang dikelilingi oleh dataran tinggi dan perbukitan, dan Semarang bawah dibagian utara yang merupakan daerah dengan dataran yang lebih rendah. Kondisi geografis tersebut mengakibatkan Kota Semarang sering dilanda bencana terutama bencana alam seperti banjir rob pada daerah dataran rendah dan tanah longsor pada daerah dataran tinggi. Berdasarkan kondisi geografis Kota Semarang yang rawan terhadap bencana terutama bencana alam maka, Pemerintah Daerah membentuk Badan Penanggulangan Bencana Daerah (BPBD) Kota Semarang. Pembentukan BPBD Kota Semarang ini sesuai dengan amanat yang tertuang di dalam Undang-Undang Nomor 24 Tahun 2007 tentang Penanggulangan Bencana, yang tugas utamanya adalah menyelenggarakan penanggulangan bencana mulai dari tahap prabencana, tahap saat bencana atau tahap tanggap darurat sampai tahap pascabencana, sebagaimana yang tertuang di dalam Peraturan Daerah Nomor 12 Tahun 2010 tentang Organisasi dan Tata Kerja Badan Penanggulangan Bencana Daerah Kota Semarang.
Crystal structure of 3-amino-N′-hydroxy-1H-pyrazole-4-carboximidamide, C4H7N5O
Authors: Li Yunlu 
Published: February 2024

Abstract
C4H7N5O, monoclinic, P21 (no. 4), a = 4.855(3) Å, b = 9.026(5) Å, c = 7.092(4) Å, β = 103.267(7)°, V = 302.5(3) Å3, Z = 2, Rgt
(F) = 0.0385, wRref
(F
2) = 0.1183, T = 296(2) K.
Adaptive Control of Underwater Tunnel Monitoring Robot Based on IoT and Fuzzy Neural Network Algorithm
Authors: Ye Fumeng , Wang Wenhui , He Rufei , Ouyang Jifan , Yang Xiali 
Published: February 2024

Abstract
To improve the navigation ability of underwater tunnel monitoring robots at fixed distances, directions, depths, and heights and to improve the accuracy of tunnel monitoring, an adaptive control method for underwater tunnel monitoring robots based on the Internet of Things (IoT) and fuzzy neural network algorithms is proposed. The structure of underwater tunnel monitoring robots is analyzed based on the IoT, the convolutional neural network algorithm is used to extract the tracking target characteristics of the underwater tunnel monitoring robot, and the obstacle avoidance process of the underwater tunnel monitoring robot is analyzed. The membership degree of the input variable is calculated by the fuzzy control algorithm. The control rule optimizes the neural network algorithm, obtains the target characteristics displayed by the visual tracking of the underwater tunnel monitoring robot based on the fuzzy neural network, uses the adaptive control to estimate the optimal parameters, and finally obtains the adaptive sliding mode control of the underwater tunnel monitoring robot. The experimental results show that the proposed method can accurately realize the target tracking task of the underwater tunnel monitoring robot and has better obstacle avoidance ability.
The importance of multimodal diagnostic methods for therapeutic decision making for overactive bladder in women
Authors: Ivanov Mihaela , Ceban Emil 
Published: February 2024

Background and aim. Despite overactive bladder (OAB) being a symptomatic diagnosis, all patients require a basic assessment to confirm the diagnosis, as well as to exclude any other underlying cause for lower urinary tract dysfunction. While guidelines clearly define different methods of investigations for OAB, there are reasons to believe that these guidelines reflect more of a “one size fits all” model that may not be appropriate for use in all patients. The study aimed to elucidate the complex and advanced multidisciplinary methods of investigation of OAB patients.
Methods. PubMed, ScienceDirect, Cochrane Library, and Google Scholar databases were used to search for scientific publications from 2013 to 2023 using relevant keywords and phrases.
Results. Data from 708 publications were researched and synthesized, a systematic review was carried out and the detailed and coherent results presented the diagnostic aspects of overactive bladder in women. Relevant citations from selected articles were included, and a synthesis of key information was provided.
Conclusion. These discoveries may assist in detecting OAB earlier, allowing for prompt intervention and potentially preventing the condition from progressing to more severe stages and providing healthcare professionals with valuable tools to enhance the diagnosis and treatment of OAB, potentially improving the quality of life for patients affected by this condition.
THE INFLUENCE OF FINANCIAL LITERACY AND PROMOTION LEVEL ON THE INTEREST IN USING ISLAMIC BANK PRODUCTS IN STUDENTS OF UIN SUNAN GUNUNG DJATI BANDUNG
Authors: Rihadatulaisy Yumni Alfiah , Trisyanti Anindhyta Putri 
Published: February 2024

AbstractThis research was motivated by the significant use of Islamic bank products for UIN Sunan Gunung Djati Bandung students. This paper aims to determine the influence of financial literacy and promotion on interest in becoming a Sharia bank customer for UIN Sunan Gunung Djati Bandung students. The use of methods used in this study is quantitative research methods and surveys. The population in this study was 29,350 students of UIN Sunan Gunung Djati Bandung , and a sample of 88 respondents was obtained. The sampling technique uses clusters. Data collection method by questionnaire. The results revealed that the level of Islamic financial literacy had a significant value of 0.000 < 0.05 and had a positive and significant effect on public interest in saving at Islamic banks. In contrast, promotions of 0.061 > 0.05 so that it had no effect and was not compelling to people's interest in saving at Islamic banks.Keywords: Financial Literacy, Promotion, Interest, and Islamic Bank.
Okoliczności, przebieg i następstwa sprowadzenia relikwii bł. Wincentego Kadłubka do katedry sandomierskiej w 1845 r.
Authors: Hapak Emil 
Published: February 2024

The article describes the journey of the relics of Blessed Vincent Kadlubek’s to Sandomierz Cathedral in 1845. The introduction discusses the origins of the cult of Blessed Vincent in this cathedral, the religiosity of Sandomierz residents of the first half of the 19th century, the efforts of Bishop Joseph Goldtmann to bring the relics to Sandomierz, as well as the process of obtaining them from the Cistercian monastery in Jedrzejow. The further part of the study describes their introduction to the Sandomierz Cathedral, reconstructing the course of the procession from the Reformate monastery church to the cathedral and the celebrations that followed. The last part of the article discusses the repercussions from the Russian authorities that followed these events as well as the positive consequences.
Pedagogical importance of reading literacy. A comparative study on PISA
Authors: Rosado-Castellano Fátima , Martín-Sánchez Miguel 
Published: February 2024

Reading, as complex cognitive activity, has become the focus of numerous national and international studies from a comparative perspective. This research analyses the Programme for International Student Assessment (PISA) over the last few years due to, according to the results, the low performance presented by Spanish students in reading skills. This low result is shown in the different stages analysed and it is even worse if it is considered the 2006 and 2018 reports since in those years worst results were achieved (461 and 477 points respectively).
In order to do this, different factors that have an influence on reading skills are analysed. It is done a comparative and longitudinal research from 2000 to 2018 that considers all the results provided by OECD. With that data in mind and the purpose of understanding them and contextualize those factors that could rise to them, other elements are studied, such as the presence of the reading skills in the Spanish legislation, the investment made in Secondary Education, the rate of students who finish Compulsory Secondary School, as well as the evolution that school libraries have had in terms of number, uses or the participation of families and the environment in them. These aspects are analysed in a way that is compared with the reading performance obtained throughout the PISA studies. Finally, the approach of the PISA reports justifies its use as a reference for a qualitative and global understanding of the aspects that interfere with appropriate reading skills in fifteen-year-old students. This goes beyond numerical results.
Ansiedad rasgo, respuestas rumiativas y evolución del dolor en futbolistas lesionados
Authors: Muñoz Sánchez Carmen , Redondo Amador Blas , Gil Caselles Laura , Olmedilla Aurelio 
Published: February 2024

La ansiedad rasgo y otros procesos emocionales se pueden relacionar con la percepción del dolor en deportistas lesionados, lo que puede dificultar las conductas de adherencia al programa de rehabilitación de éstos. Este estudio pretende dos objetivos: determinar la relación entre la ansiedad rasgo y la percepción de dolor durante el proceso de rehabilitación en futbolistas lesionados y determinar la relación entre las respuestas rumiativas de futbolistas lesionados y la percepción de dolor durante el proceso de rehabilitación. La muestra estuvo formada por 22 futbolistas lesionados, con una edad media de 20,32±0,99, cuyas lesiones eran graves y moderadas. Se evaluó el nivel de ansiedad rasgo, el nivel de respuestas rumiativas y la percepción de dolor durante 21 días durante la rehabilitación. Los resultados mostraron que el grupo de jugadores con niveles altos de ansiedad rasgo manifestaba una percepción del dolor significativamente mayor que el grupo de jugadores con niveles bajos de ansiedad rasgo, y que el grupo de jugadores con niveles altos de rumiación manifestaba una percepción del dolor significativamente mayor que el grupo de jugadores con niveles bajos de rumiación. Los valores obtenidos en la percepción de dolor disminuyeron significativamente a lo largo del tiempo, tanto en los grupos de alta y baja rumiación como en los grupos de alta y baja ansiedad. El grupo de futbolistas lesionados con alto nivel de ansiedad rasgo manifestó una percepción de dolor de entre 3 y 5 puntos más que el grupo con bajo nivel de ansiedad rasgo en las 5 primeras tomas de datos. El grupo de futbolistas lesionados con alto nivel de respuestas rumiativas manifestó, en las 5 primeras tomas de datos, valores de percepción de dolor de 2 puntos aproximadamente más que el grupo con bajo nivel de respuestas rumiativas.
A descriptive study to assess the level of perception and satisfaction regarding online learning among undergraduate nursing students in selected nursing college, Guwahati, Assam
Authors: Kumari Sujata 
Published: February 2024

The COVID 19 pandemic has disrupted the educational system and lead to a drastic shift of professional undergraduate teaching for nursing students into online mode. The definition of satisfaction in online learning is complex and multidimensional and includes manufacturers such as communication student participation in online discussion flexibility workload technology support and feedback. Satisfaction with online learning is based on three learning theories: -social cognitive theory interaction equivalency theory and social integration theory. There is a growing body of literature showing that satisfaction has a positive relationship with student engagement and academic performance the quality of learning is effectiveness success and institutional cost-effectiveness.To assess the students’ level of perception regarding online learning. To determine the level of satisfaction regarding online learning.A descriptive study of 138 sample nursing students. Qualitative research approach was used in this study and convience sampling techniques was used Research methodology means an agreement that depicts how, at what times and information is to be collected and scrutinized. It involves all the approach, to answer the research problem. The techniques used to structure a study and to gather and analyze information in a systematic fashion is referred as the research methodology. It includes the steps, action and approaches for the gathering and analyzing the data. The present study adopts a qualitative research approach.: The data analysis was done with the help of descriptive inference statistics for level of satisfaction. 88(63.76%) of undergraduate nursing student had moderate level of satisfaction regarding online learning. 30(21.73%) undergraduate nursing student had poor level of satisfaction regarding online learning and 20(14.49%) undergraduate students had good level of satisfaction. For perception the majority i.e., 90(65%) of undergraduate nursing student had poor perception, 43(32%) of undergraduate nursing student had moderate perception and 5(3.6%) of undergraduate nursing student had good perception regarding online learning.: Nursing is the practice where we can learn theoretically as well as practically. The online learning has played a major role in the development of the skill and knowledge of the nurses and nursing student, in order to that the study which we have conducted says that The e-learning has affected the level of perception and satisfaction among the nursing undergraduate student.