bluuebunny/crossref_metadata_2025_split huggingface dataset:
Floral ontogeny reveals synapomorphies for Senegalia sect. Monacanthea p.p. (Leguminosae)
Authors: Alvarado-Reyes Anderson Javier , Paulino Juliana Vilella , Terra Vanessa Santos da , Mansano Vidal de Freitas 
Published: January 2024

Abstract

The genus Senegalia was recently described as non-monophyletic; however, its sections exhibit robust monophyletic support, suggesting a potential reclassification into separate genera. Senegalia sect. Monocanthea p.p. is the largest section and contains 164 species of pantropical distribution and includes all of the current 99 neotropical species of Senegalia; however, no morphological characteristics are available to differentiate this section. To characterize this section, we examined floral developmental traits in four species of Senegalia sect. Monocanthea p.p. These traits were previously considered as potentially distinguishing features within Acacia s.l. and include the onset patterns of the androecium, the timing of calyx union, the origin of the staminal disc, and the presence of stomata on the petals. Furthermore, we analyzed previously unexplored traits, such as corolla union types, inflorescence development, and micromorphological features related to the indumentum, as well as the presence and location of stomata. All these characters were analyzed in the context of the relationships among the studied species. The characteristics proposed as potential synapomorphies of the group include the postgenital fusion of the corolla and the presence of a staminal disc formed at the base of the filaments. The other analyzed floral characteristics were not informative for the characterization of the group and exhibited limited correlation with the phylogenetic position of the Senegalia species. Future studies of floral ontogeny will help to establish more precise patterns, mainly whether corolla union and staminal tube formation occur similarly in African and Asian sections of Senegalia.
Hematologic system damage is common and related to severity in patients with acute hepatitis E
Authors: Cao Xuemei , Chen Jie , Liu Yushuang , Yang Yuling , Zhang Shujun 
Published: January 2024

Abstract

Background: Extrahepatic manifestations of hepatitis E have been extensively reported, yet there is a lack of comprehensive systematic studies on this aspect. This article is to report hematologic systemdamage caused by hepatitis E.
Methods: A retrospective study enrolled 170 patients with acute hepatitis E. The study analyzed the proportion of patients with decreased white blood cell, hemoglobin, and platelet levels in their blood routine, along with their potential clinical significance. 49 patients with HA were also included as controls to compare and analyze the differences in biochemical indicators and hematologic damage.
Results: Among the 170 patients with hepatitis E, 47 cases (27.64%) presented with leukopenia, 94 cases (55.29%) exhibited anemia, and 33 cases (19.41%) experienced thrombocytopenia. The findings indicated that hemoglobin and platelets are lower in patients with hepatitis E than in patients with hepatitis A, and anemia is more common in patients with hepatitis E. The anemia group had significantly lower levels of albumin, alanine aminotransferase, and cholinesterase compared to the normal group (p<0.001, p=0.005, p<0.001). Additionally, total bilirubin and alkaline phosphatase were significantly higher in the anemia group than in the normal group (p=0.031, p=0.003). Moreover, the anemia group showed a higher likelihood of experiencing spontaneous bacterial peritonitis (p=0.025). In comparison to the normal platelet group, the thrombocytopenia group exhibited significantly lower levels of albumin, cholinesterase, and prothrombin activity (p=0.036, p=0.015, p<0.001). Patients with decreased platelet have the higher incidence of death, spontaneous bacterial peritonitis, upper gastrointestinal bleeding and hepatorenal syndrome (p<0.001, p<0.001, p=0.027, p=0.014).
Conclusion: Hepatitis E patients with hematologic system damage are common. Patients with hepatitis Ehave lower levels of hemoglobin and platelets compared to patients with hepatitis A. The presence of anemia and low platelets in patients with hepatitis Eindicates a more severe condition.
The association between Helicobacter pylori infection and pancreatic diseases: a Mendelian Randomization study
Authors: Zhu Mengjia , Zhang Dian , Chen Angli , Wang Xinjie , Hu Weiling 
Published: January 2024

Abstract
Object:
The relationship between Helicobacter pylori and pancreatic diseases remains a subject of controversy. Our study aims to investigate the association between Helicobacter pylori infection and pancreatic cancer as well as pancreatitis.
Methods
In this study, we employed the two-sample Mendelian randomization (MR) method to assess the causal relationship between anti-Helicobacter pylori antibody levels and the occurrence of pancreatic cancer and pancreatitis. The primary analytical approach was determined to be the inverse variance-weighted (IVW) analysis under a fixed-effects model. To ensure the reliability of our study findings, we conducted multiple sensitivity analyses.
Results
Our research reveals a significant correlation between elevated levels of anti-Helicobacter pylori outer membrane protein (OMP) and a reduced risk of alcohol-induced chronic pancreatitis (ACP) (OR, 0.654; 95% CI, 0.508–0.841; p < 0.05). Multivariable Mendelian randomization (MR) analysis indicates that C-reactive protein (CRP), as opposed to monocyte chemoattractant protein-1 (MCP-1), peptic ulcers, gastric ulcers, and duodenal ulcers, mediates the causal relationship between Helicobacter pylori infection and alcoholic chronic pancreatitis (ACP). Furthermore, our study findings exhibit no evidence of heterogeneity or pleiotropy.
Conclusion
The two-sample Mendelian randomization (MR) analysis reveals a causal relationship between anti-Helicobacter pylori OMP levels and ACP. Further investigations are warranted to elucidate and validate these findings.
A machine learning approach to prediction of HER2/PR/ER status in metastatic breast cancer to the brain from magnetic resonance imaging.
Authors: Sabal Luke T. , Venteicher Andrew S. , Taha Birra R. 
Published: January 2024

Abstract
Introduction
Breast cancer brain metastases (BCBM) are a clinical challenge, with 15–25% incidence among patients with metastatic breast cancer. Prediction of receptor status in BCBM is crucial for personalized treatment strategies. This study addresses the limitations of invasive biopsies and explores the use of machine learning techniques to predict BCBM receptor status based on primary breast cancer histology.
Methods
1135 lesions from 196 scans and 173 unique patients were analyzed. Genetic information was obtained using next-generation sequencing or immunohistochemistry. We employed machine learning algorithms to predict receptor status from radiomic features extracted from T1-weighted post-contrast MRI images.
Results
Random Forest classifier demonstrated superior performance in predicting HER2 and ER status. The 'Minimum' feature from radiomic analysis was the most significant in determining mutation status. Unsupervised analysis showed distinct clustering for certain genetic combinations.
Conclusion
Machine learning models, particularly the Random Forest classifier, can effectively predict HER2 and ER receptor status in BCBM from MRI radiomic features. This approach could offer a pathway toward personalized therapy and potentially improved patient outcomes. This study is limited by known receptor discordance between primary breast lesions and their associated brain metastases. Further validation across diverse populations and multicenter studies is necessary.
SGLT2i Impact on HCC Incidence in Patients with Fatty liver disease and Diabetes: A Nation-wide Cohort Study in South Korea
Authors: Cho Hyo Jung , Lee Eunyoung , Kim Soon Sun , Cheong Jae Youn 
Published: January 2024

Abstract

This study evaluated the effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on cancer development, particularly in hepatocellular carcinoma (HCC), in individuals with concomitant fatty liver disease (FLD) and type 2 diabetes mellitus (T2DM). Using data from Korea's Health Insurance Review and Assessment Service, we performed Kaplan-Meier and Cox regression analyses in patients with non-alcoholic fatty liver disease (NAFLD) and T2DM (NAFLD-T2DM cohort) and those with chronic viral hepatitis (CVH) alongside FLD and T2DM (FLD-T2DM-CVH cohort). In the propensity score (PS) matched NAFLD-T2DM cohort (N=107,972), SGLT2i use was not associated with the occurrence of overall cancer, including HCC. However, old age, male sex, liver cirrhosis, and hypothyroidism were identified as independent risk factors for HCC occurrence, whereas statin and fibrate usage were associated with reduced HCC risk in this cohort in multivariate Cox analysis. In the PS-matched FLD-T2DM-CVH cohort (N=2,798), a significant decrease in HCC occurrence was observed among SGLT2i users (P=0.03). This finding remained consistent in the multivariate Cox regression analysis (Hazard ratio = 2.21, 95% confidence interval =1.01-4.85, P=0.048). In conclusion, SGLT2i may be a beneficial option for diabetes management in patients with concomitant T2DM, FLD, and CVH while affirming the overall safety of SGLT2i in other types of cancer.
Evaluation of the suitability of Baishiling tourism resources development and its development model: An application of entropy weighting and cluster analysis
Authors: Maozheng Fu , Liying Feng , Zhenrong Luo 
Published: January 2024

Abstract
The purpose of this study is to assess the development suitability and development pattern of Baishi Ling resource tourism in Qionghai, Hainan. The research methodology includes the construction of a four-dimensional influence system model (traffic dominance, population and economy, tourism location, and resource endowment), the use of the entropy weight method to assess the suitability of the Baishiling resource tourism development, and the use of ArcGIS software to visualize the analysis results. The results of the study show that Baishi Ridge resources are distributed in bands, the suitability scores fluctuate widely, and high value areas are initially formed. In addition, the cluster analysis showed that the degree of traffic dominance and tourism location had a greater influence on the resource sites. Ultimately, this study proposes a "one belt, two cores and three zones" tourism development model for Baishi Ling resources, which provides useful guidance and reference for the development of tourism in the area.
A novel computer-assisted drill guide template for guided correction of genu varum
Authors: Zou Ming , He Youzhi , Shi Qiang 
Published: January 2024

Abstract

Background: 8-plate hemiepiphysiodesis is widely used for treatment of genu varum. This present study is aimed to retrospectively explore the feasibility and efficacy of a novel computer-assisted drill guide template for guided correction of genu varum in children.
Methods: Twenty-eight patients who underwent 8-plate hemiepiphysiodesis due to genu varum from June 2014 to June 2018 were retrospectively analyzed in our hospital. All cases were treated with 8-plate hemiepiphysiodesis and ultra-low-dose computed tomography (CT) scans of knee joint before surgery. Novel 3D printed digital navigation templates were used in 14 cases, while traditional surgery was used in other 14 cases. The radiation exposure, surgical time, valgus correction degrees, and complications were compared between the two groups.
Results: All 3D printed digital navigation templates matched well with the anatomical markers of distal femur for preoperative planning and intraoperative procedures. Average operation times were 27.5 min (21.0-38.0 min) for the individualized navigation template group and 33.3 min (22-53 min) for the traditional operation group (p=0.0434). Average radiation exposure times were 4.8 times (3.0-8.0 times) for the individualized navigation template group and 7.5 times (5.0-9.0 times) for the traditional operation group (p<0.0001). Average rate of correction for mLDFA between individualized navigation template group and the traditional operation group were 11.0 ± 5.1 and 12.7 ± 4.8 (p=0.035). In the conventional group, the duration was 11.4±5.7 months while in navigation template group this period amounted to 11.0 ±6.1 months without a statistically significant difference (p=0.594).
Conclusions: The Novel 3D printed digital navigation template can simplify the surgical procedure, reduce the operating time, and achieve less radiation exposure for treatment of genu varum in children.
A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess
Authors: Li Xufeng , Sheng Jifang 
Published: January 2024

Abstract

Aims:
PLA (pyogenic liver abscess) has become a common disease, but the percentage of positive cultures of PLA is low. This study summarizes methods for empirically guiding the administration of PLA even without culture results.
Method:
The clinical data, clinical characteristics, drug resistance, and liver abscess culture results of 398 patients with PLA were recorded and analyzed retrospectively.
Results:
For the new findings, there was a significant correlation between KP (Klebsiella pneumoniae) and a high incidence of right lobe of PLA,(P<0.001); There was significant correlation between E.coli(Escherichia coli) and a high incidence of left lobe of PLA.༈P<0.001༉
Conclusions:
In patients with PLA whose abscess lesion was located in the right liver, KP was the first consideration, and a third-generation cephalosporin or third-generation cephalosporin/enzyme inhibitor was started. When the abscess is located in the left liver, the presence of E. coli should be considered, and treatment with third-generation cephalosporin/enzyme inhibitors or carbapenems should be started. When the abscess is located in the caudate liver, the pathogenic bacteria may be Streptococcus. Metronidazole and ampicillin are not recommended as first-line anti-infective agents for PLA.
P3H1 as a novel prognostic biomarker correlates with immune infiltrate
Authors: Wu Changmeng , You Xinxin , Li Bowen , Wang Qiu , Li Mingyang , Wen Jing , Lin Yu , Jiang Hang , Xie Weijie , Xia Yong , Ji Ling 
Published: January 2024

Abstract

Background
Prolyl 3-hydroxylase 1(P3H1), a member of the collagen prolyl hydroxylase family, plays an important role in the development and progression of malignant tumors. However, expression and prognostic value of P3H1 and its correlation with tumor immunity in some cancer remain unclear.
Methods
We identified transcription level in the P3H1 gene by searching the GEPIA2.0 and ULCAN databases, and then analyzed the relationship between gene expression and prognosis in each tumor using survival R package, and computed the log-rank P value and hazard ratio (HR) with 95% confidence intervals (95% CI). Specifically, we used the oncomine and databases to further explore the relationship between P3H1 expression and the cancer prognosis. Moreover, we further investigated the role of P3H1 in tumor immunology using TIMER2.0 database. The relationship between the expression of this gene and TMB, NEO and MSI were also evaluated. More importantly, we performed signaling pathway enrichment analysis by KEGG and GO. Then, anticancer drug sensitivity analysis was performed using the pRRophetic R package. Finally, ELISA analysis was performed to compare the P3H1 serum level both the patients of COAD and healthy subjects.
Results
P3H1 was abnormally overexpressed in multiply tumors and distinct associations exist between P3H1 expression and prognosis of tumor patients by analysis online data. Moreover, we identified a strong correlation between P3H1 expression and immune checkpoint gene expression in diverse cancers. High expression of P3H1 was correlated with the immune infiltrated in COAD. Remarkably, a positive correlation between P3H1 expression and tumor mutation burden and neoantigen in colon adenocarcinoma (COAD) was observed. Furthermore, P3H1 was involved in the extracellular matrix organization and immune-related pathways in COAD. In addition, drug sensitivity analysis revealed that high P3H1 group has higher sensitivity in diverse drug for the therapy of COAD compared to low P3H1 group. Finally, the serum level of P3H1 was much higher in patients with COAD than in control subjects, indicating a link between P3H1 and COAD.
Conclusion
Our study provides a comprehensive insight for revealing the significant role of P3H1 in the expression, survival, tumor immune, microenvironment of human cancers, and anticancer drug sensitivity analysis of COAD.
Ocular complications in pediatric non-infectious anterior uveitis in long-term follow-up
Authors: Siiskonen Mira , Hirn Iida , Pesala Roosa , Ohtonen Pasi , Kubin Anna-Maria , Hautala Nina 
Published: January 2024

Abstract

Background
Pediatric uveitis is often asymptomatic, which may expose to sight-threatening ocular complications. The impact of modern medication on frequency of long-term ocular complications in pediatric patients with anterior idiopathic uveitis (IU) or juvenile idiopathic arthritis associated uveitis (JIA-U) is not fully understood. We aimed to evaluate the effect of modern treatment on ocular complications in the population-based cohort of children with anterior idiopathic uveitis (IU) or juvenile idiopathic arthritis associated uveitis (JIA-U).
Methods
A longitudinal, population-based cohort study of children with IU or JIA-U in 2008–2020. Variables assessed included age, gender, age at diagnosis, laterality, chronicity, vision, and ocular complications.
Results
107 pediatric patients and 172 eyes with either IU (19 patients) or JIA-U (88 patients) were included. The mean age at uveitis onset was 10.0 ± 3.7 and 5.4 ± 3.2 years in IU and JIA-U, respectively (p < 0.001). Uveitis was chronic in 58% in IU and 74% in JIA-U patients, respectively. Uveitis was complicated with glaucoma in 45% of IU and 18% of JIA-U patients (p = 0.019). Cataract was developed in 31% of IU and 22% of JIA-U eyes (p = 0.28), and posterior synechiae in 21% and 9% of the eyes with IU and JIA-U, respectively. None of the eyes were hypotonic. Female gender was overrepresented in ocular complications. Glaucoma surgery was accomplished in 25 (15%) and cataract surgery in 19 (11%) eyes. Bilateral visual acuity remained > 0.5 in all patients.
Conclusions
Glaucoma, ocular hypertension, and cataract were the most typical complications of uveitis. Complications occurred mostly in girls and in IU patients. JIA-U patients with severe uveitis, young age at uveitis onset and female gender were predisposing factors for surgical management. Screening for JIA-U and modern treatment of uveitis has improved the prognosis of pediatric uveitis despite the development of ocular complications.
Combining two parasitoids (Asecodes hispinarum and Tetrastichus brontispae) for biological control of coconut leaf beetle
Authors: 张 起恺 , Jiao Bin , Lu Hui , Tang Jihong , Zhang Xu , Lyu Baoqian 
Published: January 2024

Abstract
The coconut leaf beetle (CLB), Brontispa longissima, is a major threat to coconut production worldwide, causing widespread and important losses throughout the tropics. Two eulophid parasitoids, Asecodes hispinarum and Tetrastichus brontispae, are the dominate natural enemies of CLB, but methods for their synergistic use have not previously been developed that would minimize interspecific conflicts and maximize their combined impact. We analyzed the interactions of A. hispinarum and T. brontispae and evaluated possible deployment strategies by determining the outcomes of releases under realistic agricultural conditions. Our laboratory studies showed that the concurrent release of the two parasitoid species did not reduce either species lifespan or reproductive output, and it significantly enhanced the impact on CLB. A 3:1 ratio of A. hispinarum to T. brontispae, a 10:1 parasitoid-to-pest ratio, and a regimen of five consecutive monthly releases proved to be the most efficacious strategy in the laboratory. Field trials over a two-year period consistently demonstrated the advantages of this combined release approach, resulting in significant reductions in pest populations and increases in parasitism rates. This study highlights the potential of integrating multiple parasitoid species to improve biological control impacts, example the context of sustainable pest management strategies.
Cracking performance sensitivity to material parameters of asphalt mixture in asphalt pavement with stabilized base with inorganic binders
Authors: Wu Chenhui , Wang Xiaoying , Li Kai , Ding Yong , Xu Qian 
Published: January 2024

Abstract

Fracture parameters of asphalt mixture have a great influence on reflective cracking propagation in asphalt pavement with stabilized base with inorganic binders, which is generally constructed in heavy traffic region. Many methods have been conducted to improve the temperature performance of asphalt mixture to reduce reflective crack. However, the relation between fracture parameters of asphalt mixture and cracking propagation law has not been investigated. In this study, cracking performance sensitive to material parameters of asphalt mixture in asphalt pavement was researched. Two kinds of thermal field models of pavement structure were built to obtain great falling temperature and circle temperature, which were used as the external temperature load to induce thermally reflective crack. The thermally reflective cracking propagation and sensitivity to fracture parameters of asphalt mixture were analyzed. In addition, the relationship between fatigue time and fatigue parameters defined in fatigue crack growth initiation criterion and fatigue crack growth completion criterion was investigated. Crack initiation temperature difference had a power relationship with elastic modulus, a linear relationship with tensile strength, but had no relationship with fracture energy. Crack completion temperature difference had a power relationship with elastic modulus, and a quadratic function with fracture energy. The results provided new insight into the cracking performance sensitivity to material parameters of asphalt mixture in reflective crack in asphalt pavement.