bluuebunny/crossref_metadata_2025_split huggingface dataset:
Per- and Polyfluoroalkyl Substances Concentrations are Associated with an Unfavorable Cardio-Metabolic Risk Profile: Findings from Two Population-Based Cohort Studies
Authors: Faquih Tariq O. , Landstra Elvire N. , van Hylckama Vlieg Astrid , Aziz N. Ahmad , Li-Gao Ruifang , de Mutsert Renée , Rosendaal Frits R. , Noordam Raymond , van Heemst Diana , Mook-Kanamori Dennis O. , van Dijk Ko Willems , Breteler Monique M. B. 
Published: February 2024

AbstractPer- and polyfluoroalkyl substances (PFAS) are widely used and persistent chemicals, leading to ubiquitous exposure. Although high PFAS levels have been associated with an adverse cardiovascular risk profile, the distribution of levels and relations with cardio-metabolic risk markers in the general population have not been fully characterized. We assessed the association between blood levels of perfluorooctaneic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) and a range of lipoproteins and metabolites as well as clinical lipid measurements. We used data from participants of the Netherlands Epidemiology of Obesity study (NEO) (n = 584) and the Rhineland Study (n = 1962), jointly spanning an age range of 30 to 89 years. PFAS were measured with the Metabolon HD4 platform, and lipoprotein and metabolite profiles were measured using Nightingale’s nuclear magnetic resonance-spectroscopy platform, and mainly comprised lipoprotein markers. Using linear regression analyses, we quantified age-, sex-, and education-adjusted associations of PFOA, PFOS, and PFHxS with clinical lipid measurements and 224 lipoproteins and metabolites. Higher levels of PFAS, particularly PFOS and PFHxS, were associated with higher concentrations of total lipid, cholesterol and phospholipid content in most HDL, IDL, LDL, and VLDL subclasses. The effect sizes were age-dependent for the majority of the associations, with the deleterious effects of PFAS being generally stronger in people below compared to those above median age. Our observation that in the general population even low PFAS concentrations are associated with an unfavorable lipid profile, calls for further critical regulation of PFAS substances.
Severe pediatric COVID-19: a review from the clinical and immunopathophysiological perspectives
Authors: Sun Yi-Kan , Wang Can , Lin Pei-Quan , Hu Lei , Ye Jing , Gao Zhi-Gang , Lin Ru , Li Hao-Min , Shu Qiang , Huang Li-Su , Tan Lin-Hua 
Published: February 2024

Abstract
Background
Coronavirus disease 2019 (COVID-19) tends to have mild presentations in children. However, severe and critical cases do arise in the pediatric population with debilitating systemic impacts and can be fatal at times, meriting further attention from clinicians. Meanwhile, the intricate interactions between the pathogen virulence factors and host defense mechanisms are believed to play indispensable roles in severe COVID-19 pathophysiology but remain incompletely understood.

Data sources
A comprehensive literature review was conducted for pertinent publications by reviewers independently using the PubMed, Embase, and Wanfang databases. Searched keywords included “COVID-19 in children”, “severe pediatric COVID-19”, and “critical illness in children with COVID-19”.

Results
Risks of developing severe COVID-19 in children escalate with increasing numbers of co-morbidities and an unvaccinated status. Acute respiratory distress stress and necrotizing pneumonia are prominent pulmonary manifestations, while various forms of cardiovascular and neurological involvement may also be seen. Multiple immunological processes are implicated in the host response to COVID-19 including the type I interferon and inflammasome pathways, whose dysregulation in severe and critical diseases translates into adverse clinical manifestations. Multisystem inflammatory syndrome in children (MIS-C), a potentially life-threatening immune-mediated condition chronologically associated with COVID-19 exposure, denotes another scientific and clinical conundrum that exemplifies the complexity of pediatric immunity. Despite the considerable dissimilarities between the pediatric and adult immune systems, clinical trials dedicated to children are lacking and current management recommendations are largely adapted from adult guidelines.

Conclusions
Severe pediatric COVID-19 can affect multiple organ systems. The dysregulated immune pathways in severe COVID-19 shape the disease course, epitomize the vast functional diversity of the pediatric immune system and highlight the immunophenotypical differences between children and adults. Consequently, further research may be warranted to adequately address them in pediatric-specific clinical practice guidelines.
Prevalence and Risk Factors for Musculoskeletal Pain when Running During Pregnancy: A Survey of 3102 Women
Authors: Wyatt Hannah E. , Sheerin Kelly , Hume Patria A. , Hébert-Losier Kim 
Published: February 2024

Abstract
Background
Musculoskeletal pain while running is a concern to women during pregnancy and can lead to running cessation. To support women who wish to run during pregnancy, it is essential to understand the sites, severities and personal risk factors associated with musculoskeletal pain.

Objective
The aim was to investigate prevalence and risk factors for musculoskeletal pain when running during pregnancy.

Methods
An online survey was completed by women who had a child in the past 5 years and ran prior to and during pregnancy. Pain frequency informed prevalence rates by body site, and logistic regression odds ratios (ORs) and 95% confidence intervals were calculated.

Results
A total of 3102 women of 23 ethnicities from 25 countries completed the survey. Women were 22–52 years old when they gave birth and ran 2–129 km/week during the 0.5–35 years before the birth of their youngest child. Women ran significantly less distance and less often during pregnancy than before pregnancy. Most women (86%) experienced pain while running during pregnancy (59% pelvis/sacroiliac joint, 52% lower back, 51% abdomen, 44% breast, 40% hip). The highest prevalence of severe-to-worst pain was at the pelvis/sacroiliac joint (9%). Women at greatest risk of pain while running during pregnancy had a previous injury (OR = 3.44) or were older (OR = 1.04). Women with a previous child were less likely to experience breast pain (OR = 0.76) than those running during their first pregnancy.

Conclusion
Healthcare practices to reduce pain should focus on regions of greatest musculoskeletal change during pregnancy, specifically the pelvis, lower back and abdomen. Efforts to support women to run for longer throughout pregnancy should focus on pain at the pelvis and breasts.
Fundamental Understanding of Hydrogen Evolution Reaction on Zinc Anode Surface: A First-Principles Study
Authors: Liu Xiaoyu , Guo Yiming , Ning Fanghua , Liu Yuyu , Shi Siqi , Li Qian , Zhang Jiujun , Lu Shigang , Yi Jin 
Published: February 2024

AbstractHydrogen evolution reaction (HER) has become a key factor affecting the cycling stability of aqueous Zn-ion batteries, while the corresponding fundamental issues involving HER are still unclear. Herein, the reaction mechanisms of HER on various crystalline surfaces have been investigated by first-principle calculations based on density functional theory. It is found that the Volmer step is the rate-limiting step of HER on the Zn (002) and (100) surfaces, while, the reaction rates of HER on the Zn (101), (102) and (103) surfaces are determined by the Tafel step. Moreover, the correlation between HER activity and the generalized coordination number ($$\overline{CN }$$

CN

¯

) of Zn at the surfaces has been revealed. The relatively weaker HER activity on Zn (002) surface can be attributed to the higher $$\overline{CN }$$

CN

¯

of surface Zn atom. The atomically uneven Zn (002) surface shows significantly higher HER activity than the flat Zn (002) surface as the $$\overline{CN }$$

CN

¯

of the surface Zn atom is lowered. The $$\overline{CN }$$

CN

¯

of surface Zn atom is proposed as a key descriptor of HER activity. Tuning the $$\overline{CN }$$

CN

¯

of surface Zn atom would be a vital strategy to inhibit HER on the Zn anode surface based on the presented theoretical studies. Furthermore, this work provides a theoretical basis for the in-depth understanding of HER on the Zn surface.
Deep Learning Low-cost Photogrammetry for 4D Short-term Glacier Dynamics Monitoring
Authors: Ioli Francesco , Dematteis Niccolò , Giordan Daniele , Nex Francesco , Pinto Livio 
Published: February 2024

AbstractShort-term monitoring of alpine glaciers is crucial to understand their response to climate change. This paper presents a low-cost multi-camera system tailored for 4D glacier monitoring using deep learning stereo-photogrammetry. Our approach integrates multi-temporal 3D reconstruction from stereo cameras and surface velocity estimation from a monoscopic camera through digital image correlation. To address the challenges posed by wide camera baselines in complex environments, we have integrated state-of-the-art deep learning feature matching algorithms into ICEpy4D, a Python toolkit designed for 4D monitoring (https://github.com/franioli/icepy4d). In a pilot study conducted on the debris-covered Belvedere Glacier (Italian Alps), our stereoscopic setup, with a camera base–height ratio close to one, captured daily images from May to November 2022. Our approach utilized SuperPoint and SuperGlue for feature matching, resulting in a daily 3D reconstruction of the glacier terminus, as traditional SIFT-like feature matching fails in this scenario. Using dense point clouds with decimetric accuracy, we estimated daily ice volume loss and glacier retreat at the terminus. The total ice volume loss was $$63\,000\,\text{m}$$

63 000

m

$${}^{3}$$

3

and the retreat was $$17.8\,\text{m}$$

17.8

m

. Surface kinematics revealed three times higher surface velocity during the warm season (May–September) than in the fall (September–November). Daily analyses revealed a significant short-term correlation between air temperature, glacier surface velocity and ice ablation, providing insight into the glacier’s response to external forces. The low cost and ease of deployment of the proposed system facilitates replication at other sites for short-term monitoring of glacier dynamics.
Being prosocial and happy, and believing in life-determining forces across cultures
Authors: Berniūnas Renatas , Rimkevičius Paulius , Beinorius Audrius , Dranseika Vilius , Silius Vytis 
Published: February 2024

AbstractBelieving that your life is shaped by internal forces, such as your own free will, is usually thought to lead to positive outcomes, such as being prosocial and happy. Believing that it is shaped by external forces, such as deterministic laws of nature, is usually thought to lead to negative outcomes. However, whether that is the case might vary with culture and with the nature of the force, specifically, whether the force is teleological. To test this, we investigated beliefs in five countries: China, India, Lithuania, Mongolia, and the USA. We investigated beliefs in the importance of choice (an internal, teleological force), gods and fate (external, teleological forces), and chance and luck (external, non-teleological forces). Participants (N = 1035) played a hypothetical dictator game, rated their happiness, and rated how much, in their opinion, their life is determined by these forces. Choice was perceived as the most important and its perceived importance was positively associated with subjective happiness across cultures. It was also positively associated with prosocial intentions, although only in India. Perceived importance of gods and fate was mostly positively associated with prosocial intentions. Perceived importance of gods, but not fate, was positively associated with subjective happiness across cultures. Finally, perceived importance of chance and luck was mostly either negatively associated with prosocial intentions and subjective happiness or not at all. Our results highlight the importance of studying agency beliefs in different cultures and distinguishing different kinds of determination: not just internal and external but also teleological and non-teleological.
Unraveling two decades of phyllosphere endophytes: tracing research trends and insights through visualized knowledge maps, with emphasis on microbial interactions as emerging frontiers
Authors: Muneer Muhammad Atif , Chen Xiaohui , Wang Hexin , Munir Muhammad Zeeshan , Afridi Muhammad Siddique , Yan Xiaojun , Ji Baoming , Li Wenqing , Wu Liangquan , Zheng Chaoyuan 
Published: February 2024

AbstractPhyllosphere endophytes play a critical role in a myriad of biological functions, such as maintaining plant health and overall fitness. They play a determinative role in crop yield and quality by regulating vital processes, such as leaf functionality and longevity, seed mass, apical growth, flowering, and fruit development. This study conducted a comprehensive bibliometric analysis aiming to review the prevailing research trajectories in phyllosphere endophytes and harness both primary areas of interest and emerging challenges. A total of 156 research articles on phyllosphere endophytes, published between 2002 and 2022, were retrieved from the Web of Science Core Collection (WoSCC). A systematic analysis was conducted using CiteSpace to visualize the evolution of publication frequency, the collaboration network, the co-citation network, and keywords co-occurrence. The findings indicated that initially, there were few publications on the topic of phyllosphere endophytes. However, from 2011 onwards, there was a notable increase in the number of publications on phyllosphere endophytes, gaining worldwide attention. Among authors, Arnold, A Elizabeth is widely recognized as a leading author in this research area. In terms of countries, the USA and China hold the highest rankings. As for institutional ranking, the University of Arizona is the most prevalent and leading institute in this particular subject. Collaborative efforts among the authors and institutions tend to be confined to small groups, and a large-scale collaborative network needs to be established. This study identified the influential journals, literature, and hot research topics. These findings also highlight the interconnected nature of key themes, e.g., phyllosphere endophyte research revolves around the four pillars: diversity, fungal endophytes, growth, and endophytic fungi. This study provides an in-depth perspective on phyllosphere endophytes studies, revealing the identification of biodiversity and microbial interaction of phyllosphere endophytes as the principal research frontiers. These analytical findings not only elucidate the recent trajectory of phyllosphere endophyte research but also provide invaluable insights for similar studies and their potential applications on a global scale.
Application of holographic imaging in partial nephrectomy: a literature review
Authors: Wang Lei , Na Yanqun , Zhu Gang 
Published: February 2024

Abstract
Objectives
The aim of the present review was to evaluate the role of holographic imaging and its visualization techniques in providing more detailed and intuitive anatomy of the surgical area and assist in the precise implementation of surgery.

Materials and methods
Medline, Embase, and Cochrane Central databases were searched for literature on the application of holographic imaging in partial nephrectomy (PN), and the history, development, application in PN as well as the future direction were reviewed.

Results
A total of 304 papers that met the search requirements were included and summarized. Over the past decade, holographic imaging has been increasingly used for preoperative planning and intraoperative navigation in PN. At present, the intraoperative guidance method of overlapping and tracking virtual three dimensional images on endoscopic view in an augmented reality environment is generally recognized. This method is helpful for selective clamping, the localization of endophytic tumors, and the fine resection of complex renal hilar tumors. Preoperative planning and intraoperative navigation with holographic imaging are helpful in reducing warm ischemia time, preserving more normal parenchyma, and reducing serious complications.

Conclusions
Holographic image-guided surgery is a promising technology, and future directions include artificial intelligence modeling, automatic registration, and tracking.
Susceptible-Exposed-Infectious Model Using Markov Chains
Authors: Omar F. M. , Sohaly M. A. , El-Metwally H. 
Published: February 2024

Abstract
In the present work we introduced and analyzed the most basic transmission SEI (susceptible-exposed-infective) model for a directly transmitted infectious disease caused by Coronavirus disease 2019 (COVID-19). The SEI model is modeling as a Markov chain and we computed a closed form formula of the mean first passage times (MFPT’s) vector arising from non-homogeneous Markov chain random walk (NHMC-RW) on the non-negative integers. Some particular cases, which lead to a relationship between the elements of the MFPT’s vectors. An efficient algorithm applied on mathematica program for computing MFPT’s vector of the NHMC-RW is given.
Impact of stratospheric aerosol injection on photovoltaic energy potential over Nigeria
Authors: Ojo Olusola Samuel , Emmanuel Israel , Ogolo Emmanuel , Adeyemi Babatunde 
Published: February 2024

AbstractThis study evaluates the impact of the stratospheric aerosol injection (SAI) technique for solar radiation management (SRM) on the potential of photovoltaic energy in four climatic regions throughout Nigeria. The photovoltaic energy potential for the SRM scenario ($$PVE_{srm}$$

P
V

E

srm

) and the reference database ($$PVE_{ref}$$

P
V

E

ref

) were evaluated using solar radiation and temperature data from the ARISE-SAI-1.5 model and from the MERRA-2 climate data repository, respectively. Before projecting the impact of the SAI approach on photovoltaic energy generation, the agreement between $$PVE_{srm}$$

P
V

E

srm

and $$PVE_{ref}$$

P
V

E

ref

was evaluated using the index of agreement metric. The analysis showed that the index of agreement had values of 0.90 in the Sahel, 0.98 in the Guinea Savannah, 0.97 in the rainforest, and 0.82 in the coastal regions. Other validation metrics used also showed similar trends across the climatic regions in Nigeria. The projected analysis of the impact on photovoltaic energy generation between 2035 and 2069 indicated potential gains of + 5.20 in the Sahel, + 3.60 in the Guinea Savannah, and + 3.40 in the rainforest, but a decline of − 3.20 in the coastal region, all values in watts per square meters. In conclusion, this study reveals that the implementation of the SAI approach for solar radiation management would have a relatively gainful influence on solar power generation in the Sahel, the Guinea Savannah, the rainforest but declined effect in the coastal region. The results of this study provide valuable insights into the influence of solar radiation management and renewable energy generation in different climatic zones across Nigeria.
The significance of shooting angle in seal shooting
Authors: Ryeng Kathrine A , Larsen Stig E 
Published: February 2024

Abstract
The present study aimed to investigate the relationship between shooting angle to the head and animal welfare outcomes in the hunt of young harp seals (Pagophilus groenlandicus). The study population consisted of young harp seals belonging to the Greenland Sea harp seal population. A sample of 171, 2–7 weeks old, weaned harp seals of both sexes were included. The study was conducted as an open, randomised parallel group designed trial during the regular hunt. The animals were allocated into four groups, A–D, according to the observed shooting angle to the head, defined as the angle between the direction of the shot and the longitudinal axis of the animal’s head: (A) directly from the front; (B) obliquely from the front; (C) directly from the side; and (D) obliquely or directly from behind. Instantaneous death rate (IDR) and time to death (TTD) were the main variables. The mean IDR differed significantly between groups and was highest in group B (96.8%) and lowest in group C (66.7%). For all groups combined it was 84.2%. The mean TTD for seals not rendered instantaneously unconscious or dead (n = 27) differed significantly between groups and was shortest in group A (16 s) and longest in group C (85 s). However, the number of animals included in the TTD analysis was limited. In conclusion, based on the significantly higher IDR, the shooting angle obliquely from the front is recommended to help achieve the best animal welfare outcomes during the hunt of young harp seals.
Empowering the Participant Voice (EPV): Design and implementation of collaborative infrastructure to collect research participant experience feedback at scale
Authors: Kost Rhonda G. , Cheng Alex , Andrews Joseph , Chatterjee Ranee , Dozier Ann , Ford Daniel , Schlesinger Natalie , Dykes Carrie , Kelly-Pumarol Issis , Kennedy Nan , Lewis-Land Cassie , Lindo Sierra , Martinez Liz , Musty Michael , Roberts Jamie , Vaughan Roger , Wagenknecht Lynne , Carey Scott , Coffran Cameron , Goodrich James , Panjala Pavithra , Cheema Sameer , Qureshi Adam , Thomas Ellis , O’Neill Lindsay , Bascompte-Moragas Eva , Harris Paul 
Published: February 2024

Abstract
Empowering the Participant Voice (EPV) is an NCATS-funded six-CTSA collaboration to develop, demonstrate, and disseminate a low-cost infrastructure for collecting timely feedback from research participants, fostering trust, and providing data for improving clinical translational research. EPV leverages the validated Research Participant Perception Survey (RPPS) and the popular REDCap electronic data-capture platform. This report describes the development of infrastructure designed to overcome identified institutional barriers to routinely collecting participant feedback using RPPS and demonstration use cases. Sites engaged local stakeholders iteratively, incorporating feedback about anticipated value and potential concerns into project design. The team defined common standards and operations, developed software, and produced a detailed planning and implementation Guide. By May 2023, 2,575 participants diverse in age, race, ethnicity, and sex had responded to approximately 13,850 survey invitations (18.6%); 29% of responses included free-text comments. EPV infrastructure enabled sites to routinely access local and multi-site research participant experience data on an interactive analytics dashboard. The EPV learning collaborative continues to test initiatives to improve survey reach and optimize infrastructure and process. Broad uptake of EPV will expand the evidence base, enable hypothesis generation, and drive research-on-research locally and nationally to enhance the clinical research enterprise.
ACORN SDOH survey: Terminological representation for use with NLP and CDS
Authors: Resnick Melissa P. , Montella Diane , Brown Steven H. , Elkin Peter 
Published: February 2024

Abstract

Objective:
Social Determinants of Health (SDOH) greatly influence health outcomes. SDOH surveys, such as the Assessing Circumstances & Offering Resources for Needs (ACORN) survey, have been developed to screen for SDOH in Veterans. The purpose of this study is to determine the terminological representation of the ACORN survey, to aid in natural language processing (NLP).

Methods:
Each ACORN survey question was read to determine its concepts. Next, Solor was searched for each of the concepts and for the appropriate attributes. If no attributes or concepts existed, they were proposed. Then, each question’s concepts and attributes were arranged into subject-relation-object triples.

Results:
Eleven unique attributes and 18 unique concepts were proposed. These results demonstrate a gap in representing SDOH with terminologies. We believe that using these new concepts and relations will improve NLP, and thus, the care provided to Veterans.