bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of an ‘evergreening’ strategy nearing patent expiration on the uptake of biosimilars and public healthcare costs: a case study on the introduction of a second administration form of trastuzumab in The Netherlands
Authors: Kirshner Ghyli , Makai Peter , Brouns Chiara , Timmers Lonneke , Kemp Ron 
Published: January 2024

AbstractIn this paper, we explore dynamic market share and public healthcare costs of trastuzumab’s evergreening (subcutaneous) variant during introduction of trastuzumab’s competitive biosimilar variants in the Netherlands. We used a time series design to assess dynamic market share of trastuzumab’s evergreening variant after introducing trastuzumab’s biosimilar variants, focusing on the number of treatments and patients. The public healthcare costs of this evergreening strategy were estimated using administrative claims data. Our results show that the original trastuzumab was completely replaced by the subcutaneous and biosimilar variants. The uptake of the subcutaneous form peaked at 50% market share but after the introduction of biosimilars progressively reduced to a market share of 20%, resulting in a more competitive market structure. The public healthcare costs for trastuzumab significantly decreased after the introduction of the biosimilars. After the introduction of the biosimilars, a substantial price drop is visible, with the subcutaneous version, still under patent, also falling sharply in price but less strongly than the iv/biosimilar version. As the costs are publicly funded, we recommend a more explicit societal debate to consider if the potential benefits of subcutaneous Herceptin® (and other similar medicines) are worth the additional costs, and at which price it should be reimbursed as the part of the benefit package.
Students’ socioeconomic status and teacher beliefs about learning as predictors of students’ mathematical competence
Authors: Haataja Eeva S. H. , Niemivirta Markku , Holm Marja E. , Ilomanni Pia , Laine Anu 
Published: January 2024

AbstractThe learning context, consisting of the school children’s families, teachers, and peers, has effect on their mathematics learning. The concern of students’ socioeconomic status (SES) affecting negatively their learning outcomes is increasing worldwide. This study investigates whether Finnish elementary school students’ SES affects their mathematical competence and success expectancy on individual and class levels. Additionally, the role of teachers’ beliefs on mathematics learning and class composition on the mathematics competence and success expectancy on the class level is explored. To analyze the nested data from student questionnaires and mathematics tests, and their teachers’ questionnaires, we used multilevel structural equation modelling with two levels (1, individual; 2, class). The results indicate that on the individual level, the gender and SES affect students’ mathematical competence and success expectancy in mathematics. On the class level, the teacher’s evaluations of academic class composition predicted students’ mathematical competence, and the teachers’ constructivist beliefs of mathematics learning and class composition regarding students’ special needs predicted students’ success expectancy. We conclude that students with disadvantaged SES need support on success expectancy to flourish in mathematics. On the class level, this support can be conveyed through teachers’ constructivist pedagogical beliefs.
Spectral approximation scheme for a hybrid, spin-density Kohn–Sham density-functional theory in an external (nonuniform) magnetic field and a collinear exchange-correlation energy
Authors: Melgaard M. , Syrjanen V. J. J. 
Published: January 2024

AbstractWe provide a mathematical justification of a spectral approximation scheme known as spectral binning for the Kohn–Sham spin density-functional theory in the presence of an external (nonuniform) magnetic field and a collinear exchange-correlation energy term. We use an extended density-only formulation for modeling the magnetic system. No current densities enter the description in this formulation, but the particle density is split into different spin components. By restricting the exchange-correlation energy functional to be of a collinear LSDA form, we prove a series of results which enable us to mathematically justify the spectral binning scheme using the method of Gamma-convergence, in conjunction with auxiliary steps involving recasting the electrostatic potentials, justifying the spectral approximation by making a spectral decomposition of the Hamiltonian and “linearizing" the latter Hamiltonian.
A medical chart audit to assess endocrinologist perceptions of the burden of endogenous Cushing’s syndrome
Authors: Page-Wilson Gabrielle , Oak Bhagyashree , Silber Abigail , Meyer James , O’Hara Matthew , Geer Eliza B. 
Published: January 2024

Abstract
Purpose
This study was undertaken to assess the unmet needs within the endogenous Cushing’s syndrome (CS) care paradigm from the endocrinologist’s perspective, including data abstracted from patient charts. The study evaluated endocrinologists’ perceptions on burden of illness and treatment rationale along with the long-term clinical burden of CS, tolerability of CS treatments, and healthcare resource utilization for CS.

Methods
Retrospective medical chart data from treated patients with a confirmed diagnosis of CS was abstracted using a cross-sectional survey to collect data from qualified endocrinologists. The survey included a case report form to capture patient medical chart data and a web-enabled questionnaire to capture practitioner-level data pertaining to endocrinologists’ perceptions of disease burden, CS treatments, and treatment attributes.

Results
Sixty-nine endocrinologists abstracted data from 273 unique medical charts of patients with CS. Mean patient age was 46.5 ± 13.4 years, with a 60:40 (female:male) gender split. The mean duration of endogenous CS amongst patients was 4.1 years. Chart data indicated that patients experienced a high burden of comorbidities and symptoms, including fatigue, weight gain, and muscle weakness despite multi-modal treatment. When evaluating treatments for CS, endocrinologists rated improvement in health-related quality of life (HRQoL) as the most important treatment attribute (mean score = 7.8; on a scale of 1 = Not at all important to 9 = Extremely important). Surgical intervention was the modality endocrinologists were most satisfied with, but they agreed that there was a significant unmet treatment need for patients with CS.

Conclusion
Endocrinologists recognized that patients with CS suffered from a debilitating condition with a high symptomatic and HRQoL burden and reported that improvement in HRQoL was the key treatment attribute influencing their treatment choices. This study highlights unmet needs for patients with CS. Patients with CS have a high rate of morbidity and comorbidity, even after treatment.
A National Approach to Promoting Health Equity in Cardiovascular Disease Prevention: Implementation Science Strengths, Opportunities, and a Changing Chronic Disease Context
Authors: Fulmer Erika B. , Rasool Aysha , Jackson Sandra L. , Vaughan Marla , Luo Feijun 
Published: January 2024

AbstractIn the USA, structural racism contributes to higher rates of cardiovascular disease (CVD) including hypertension, heart disease, and stroke among African American persons. Evidence-based interventions (EBIs), which include programs, policies, and practices, can help mitigate health inequities, but have historically been underutilized or misapplied among communities experiencing discrimination and exclusion. This commentary on the special issue of Prevention Science, “Advancing the Adaptability of Chronic Disease Prevention and Management Through Implementation Science,” describes the Centers for Disease Control and Prevention, Division for Heart Disease and Stroke Prevention’s (DHDSP’s) efforts to support implementation practice and highlights several studies in the issue that align with DHDSP’s methods and mission. This work includes EBI identification, scale, and spread as well as health services and policy research. We conclude that implementation practice to enhance CVD health equity will require greater coordination with diverse implementation science partners as well as continued innovation and capacity building to ensure meaningful community engagement throughout EBI development, translation, dissemination, and implementation.
Application of a simplified ADM1 for full-scale anaerobic co-digestion of cattle slurry and grass silage: assessment of input variability
Authors: Tisocco Sofia , Weinrich Sören , Lyons Gary , Wills Michael , Zhan Xinmin , Crosson Paul 
Published: January 2024

AbstractMathematical modeling of anaerobic digestion is a powerful tool to predict gas yields and optimize the process. The Anaerobic Digestion Model No. 1 (ADM1) is a widely implemented model for this purpose. However, modeling full-scale biogas plants is challenging due to the extensive substrate and parameter characterization required. This study describes the modification of the ADM1 through a simplification of individual process phases, characteristic components and required parameters. Consequently, the ability of the simplified model to simulate the co-digestion of grass silage and cattle slurry was evaluated using data from a full-scale biogas plant. The impacts of substrate composition (crude carbohydrate, protein and lipid concentration) and variability of carbohydrate degradability on simulation results were assessed to identify the most influential parameters. Results indicated that the simplified version was able to depict biogas and biomethane production with average model efficiencies, according to the Nash-Sutcliffe efficiency (NSE) coefficient, of 0.70 and 0.67, respectively, and was comparable to the original ADM1 (average model efficiencies of 0.71 and 0.63, respectively). The variability of crude carbohydrate, protein and lipid concentration did not significantly impact biogas and biomethane output for the data sets explored. In contrast, carbohydrate degradability seemed to explain much more of the variability in the biogas and methane production. Thus, the application of simplified models provides a reliable basis for the process simulation and optimization of full-scale agricultural biogas plants.
Circadian functioning and time perspectives: associations with eveningness, morning affect, and amplitude distinctness
Authors: Carciofo Richard 
Published: January 2024

AbstractWell-established correlates of morningness-eveningness include those of morningness with more future Time Perspective (TP), and eveningness with more present TP. However, research into these relationships has used unidimensional measures of morningness-eveningness. So, the current study aimed to further understanding by assessing associations between TP and the separate components of Morning Affect (MA: alertness/sleep inertia after awakening) and Distinctness (DI; amplitude of diurnal variations of functioning), in addition to Eveningness (EV; time-of-day preference). Chinese university students (N = 299, aged 18–25, 94 males, 205 females) completed an online survey with questionnaire measures of TP, MA, DI, EV, and other measures including mind wandering, conscientiousness, life satisfaction, positive and negative affect, and sleep quality. Previously demonstrated correlations were replicated, including positive correlations between Future TP, conscientiousness, and life satisfaction, and Past-negative TP and more negative affect. MA positively correlated with Future TP, and negatively correlated with Past-negative TP and Deviation from Balanced Time Perspective (DBTP); DI positively correlated with Past-negative TP, and with DBTP, and negatively correlated with Future TP; EV positively correlated with Present-hedonistic TP, and negatively correlated with Future TP. The EV-Future TP association was mediated by MA. Path models were consistent with the view that the relationship between EV and less Future TP may involve impaired functioning and reduced self-control/self-regulation associated with experiencing lower Morning Affect. This research shows relationships between time perspectives and specific components of circadian functioning, indicating the value of component-level analysis and the limitations of research utilising unidimensional measures of morningness-eveningness.
Long-term clinical outcomes and health-related quality of life in patients with isolated methylmalonic acidemia after liver transplantation: experience from the largest cohort study in China
Authors: Jiang Yi-Zhou , Zhou Guang-Peng , Wei Lin , Qu Wei , Zeng Zhi-Gui , Liu Ying , Tan Yu-Le , Wang Jun , Zhu Zhi-Jun , Sun Li-Ying 
Published: January 2024

Abstract
Background
Liver transplantation (LT) has been proposed as a viable treatment option for selected methylmalonic acidemia (MMA) patients. However, there are still controversies regarding the therapeutic value of LT for MMA. The systematic assessment of health-related quality of life (HRQoL)-targeted MMA children before and after LT is also undetermined. This study aimed to comprehensively assess the long-term impact of LT on MMA, including multiorgan sequelae and HRQoL in children and families.

Methods
We retrospectively evaluated 15 isolated MMA patients undergoing LT at our institution between June 2013 and March 2022. Pre- and post-transplant data were compared, including metabolic profiles, neurologic consequences, growth parameters, and HRQoL. To further assess the characteristics of the HRQoL outcomes in MMA, we compared the results with those of children with biliary atresia (BA).

Results
All patients had early onset MMA, and underwent LT at a mean age of 4.3 years. During 1.3–8.2 years of follow-up, the patient and graft survival rates were 100%. Metabolic stability was achieved in all patients with liberalized dietary protein intake. There was a significant overall improvement in height Z scores (P = 0.0047), and some preexisting neurological complications remained stable or even improved after LT. On the Pediatric Quality of Life Inventory (PedsQL™) generic core scales, the mean total, physical health, and psychosocial health scores improved significantly posttransplant (P < 0.05). In the family impact module, higher mean scores were noted for all subscales post-LT, especially family function and daily activities (P < 0.01). However, the total scores on the generic core scales and transplant module were significantly lower (Cohen’s d = 0.57–1.17) when compared with BA recipients. In particular, social and school functioning (Cohen’s d = 0.86–1.76), treatment anxiety, and communication (Cohen’s d = 0.99–1.81) were far behind, with a large effect size.

Conclusions
This large single-center study of the mainland of China showed an overall favorable impact of LT on isolated MMA in terms of long-term survival, metabolic control, and HRQoL in children and families. The potential for persistent neurocognitive impairment and inherent metabolic fragility requires long-term special care.
Gewalt gegen Frauen
Authors: Höppner Grit 
Published: January 2024

ZusammenfassungIn dem Beitrag wird der Frage nachgegangen, warum gewaltbetroffene Frauen ab 50 Jahren, Frauen aus mittleren und höheren Bildungs- und Einkommensschichten und Frauen mit Behinderungen Angebote der Sozialen Arbeit selten nutzen, obwohl diese Angebote bei der Be- und Verarbeitung von Gewalterleben hilfreich sind. Zur Beantwortung dieser Frage werden mittels einer intersektionalen Mehrebenenanalyse Barrieren in der Inanspruchnahme dieser Angebote herausgearbeitet. Grundlage bilden jeweils zehn Interviews mit betroffenen Frauen und Fachkräften sowie zehn Websites, die inhaltsanalytisch ausgewertet wurden. Die Ergebnisse zeigen, dass Frauen im Verlauf des Gewalterlebens vier Abwägungsprozesse durchlaufen, in denen Bewertungsmaßstäbe, der Gewaltbegriff, Einstellungen und einrichtungsbezogene Spezifika zu Barrieren werden können und, dass die Entscheidung zur Nutzung von Angeboten der Sozialen Arbeit aufgrund der vielfältigen Subjektpositionen von Frauen stets in der Verschränkung mit der Strukturebene zu betrachten ist. Diese Ergebnisse schärfen das Bewusstsein für einen differenzsensiblen Gewaltschutz, damit Soziale Arbeit den eigenen Anspruch, ein Unterstützungssystem für alle gewaltbetroffenen Frauen zu sein, auch einlösen kann.
A novel cholesterol metabolism-related ferroptosis pathway in hepatocellular carcinoma
Authors: Fang Weiwei , Liu Jianyong , Zhang Fanguo , Pang Cheng , Li Xiying 
Published: January 2024

Abstract
Background
Emerging studies have reported the contribution of cholesterol to hepatocellular carcinoma (HCC) progression. However, the specific role and mechanism of cholesterol metabolism on spontaneous and progressive HCC development from the point of view of ferroptosis are still worth exploring. The present study aimed to reveal a novel mechanism of cholesterol metabolism-related ferroptosis in hepatocellular carcinoma cells.

Methods
Two microarray datasets (GSE25097, GSE22058) related to HCC were downloaded from Gene Expression Omnibus (GEO) datasets. Metabolomics analysis was performed by ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS). The cholesterol-related proteins were downloaded from HMBD. Ferroptosis-related genes were extracted from FerrDb database. Data sets were separated into two groups. GSE25097 was used to identify ferroptosis-related genes, and GSE22058 was used to verify results. During these processes, chemical–protein interaction (CPI), protein–protein interaction (PPI), the Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted. Multivariate logistic regression analysis was used to test the associated pathway.

Results
We identified 8 differentially expressed ferroptosis-related genes (HAMP, PTGS2, IL1B, ALOX15B, CDKN2A, RRM2, NQO1 and KIF20A) and 4 differentially expressed cholesterol-related genes (LCAT, CH25H, CEL and CYP7A1). Furthermore, based on the predicted results with STITCH, we identified indomethacin and IL1B as the essential node for cholesterol-mediated ferroptosis in hepatocellular carcinoma cell. Multivariate logistic regression analysis showed the activities of plasma IL1B in liver cancer patients enrolled have been significantly affected by the level of plasma cholesterol (P < 0.001) and the test result of IL1B is a predictor variable causing the changes of serum Fe levels (P < 0.001).

Conclusions
Our findings shed new light on the association between cholesterol metabolism and ferroptosis in HCC, and suggest that IL1B is the necessary node for cholesterol to lead to ferroptosis process in HCC. Also, we identified the potential role of indomethacin in adjuvant therapy of HCC with complications of abnormal cholesterol metabolism.
The development status of PET radiotracers for evaluating neuroinflammation
Authors: Lee Namhun , Choi Jae Yong , Ryu Young Hoon 
Published: January 2024

AbstractNeuroinflammation is associated with the pathophysiologies of neurodegenerative and psychiatric disorders. Evaluating neuroinflammation using positron emission tomography (PET) plays an important role in the early diagnosis and determination of proper treatment of brain diseases. To quantify neuroinflammatory responses in vivo, many PET tracers have been developed using translocator proteins, imidazole-2 binding site, cyclooxygenase, monoamine oxidase-B, adenosine, cannabinoid, purinergic P2X7, and CSF-1 receptors as biomarkers. In this review, we introduce the latest developments in PET tracers that can image neuroinflammation, focusing on clinical trials, and further consider their current implications.
Cognitive Weeding: An Approach to Single-Plant Specific Weed Regulation
Authors: Niemeyer Mark , Renz Marian , Pukrop Maren , Hagemann David , Zurheide Tim , Di Marco Daniel , Höferlin Markus , Stark Philipp , Rahe Florian , Igelbrink Matthias , Jenz Mario , Jarmer Thomas , Trautz Dieter , Stiene Stefan , Hertzberg Joachim 
Published: January 2024

AbstractThis paper provides a comprehensive overview of the architecture required to implement selective weeding in arable farming, as developed within the Cognitive Weeding project. This end-to-end architecture begins with data acquisition utilizing drones, robots, or agricultural machinery, followed by data management, AI-based data annotation, knowledge-based inference to determine the necessary treatment, resulting in an application map for selective hoeing. The paper meticulously details the various components of the architecture and illustrates through examples how they are interconnected.
A novel CE-PT-MABAC method for T-spherical uncertain linguistic multiple attribute group decision-making
Authors: Wang Haolun , Feng Liangqing , Ullah Kifayat , Garg Harish 
Published: January 2024

AbstractA T-spherical uncertain linguistic set (TSULS) is not only an expanded form of the T-spherical fuzzy set and the uncertain linguistic set but can also integrate the quantitative judging ideas and qualitative assessing information of decision-makers. For the description of complex and uncertain assessment data, TSULS is a powerful tool for the precise description and reliable processing of information data. However, the existing multi-attribute border approximation area comparison (MABAC) method has not been studied in TSULS. Thus, the goal of this paper is to extend and improve the MABAC method to tackle group decision-making problems with completely unknown weight information in the TSUL context. First, the cross-entropy measure and the interactive operation laws for the TSUL numbers are defined, respectively. Then, the two interactive aggregation operators for TSUL numbers are developed, namely T-spherical uncertain linguistic interactive weighted averaging and T-spherical uncertain linguistic interactive weighted geometric operators. Their effective properties and some special cases are also investigated. Subsequently, a new TSULMAGDM model considering the DM’s behavioral preference and psychology is built by integrating the interactive aggregation operators, the cross-entropy measure, prospect theory, and the MABAC method. To explore the effectiveness and practicability of the proposed model, an illustrative example of Sustainable Waste Clothing Recycling Partner selection is presented, and the results show that the optimal solution is h3. Finally, the reliable, valid, and generalized nature of the method is further verified through sensitivity analysis and comparative studies with existing methods.
Enhancing the Microstructure and Mechanical Properties of Cast Aluminum Matrix Composites Through Nano-Al2O3 Reinforcement via CMT and PMC Welding
Authors: Işıtan Arzum , Aytekin Süleyman , Onar Volkan 
Published: January 2024

AbstractIn this investigation, two distinct composites were produced using the liquid metallurgy vortex-route method with an aluminum AA6013 matrix and 0.5% and 1% nano-Al2O3 reinforcement by weight. The effects of nano-Al2O3 ceramic particles added into the AA6013 alloy to increase the hardness and strength of the composite were investigated. Samples for welding were prepared from cast composite materials with dimensions of 250 × 110 × 60 mm. The obtained specimens were joined via butt welding at 110-A and 120-A current intensities, and at a constant speed of 400 mm/min by cold metal transfer (CMT) and pulse multi-control (PMC) welding methods. Using the use of micro- and macrostructural evaluations, hardness measurements, and tensile testing, the impacts of each welding parameter on the mechanical characteristics and weld structure of the cast composites were examined. The composite material with 0.5% nano-Al2O3 reinforcement that was joined at 120 A utilizing the CMT process achieved the highest tensile strength value at 96.6 MPa. At 110-A and 120-A welding current values, 0.5% reinforced composite demonstrated the maximum strength in both welding techniques.