bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of urban runoff remediation potential of zinc with Juncus effusus L. and Iris pseudacorus L. plants
Authors: Greksa Amela , Žunić Vladimira , Mihajlović Ivana , Blagojević Boško , Vijuk Mirjana , Podunavac-Kuzmanović Sanja , Kovačević Strahinja , Štrbac Mirna 
Published: November 2023

Abstract
Phytoremediation is a sustainable technology that uses vegetation to remediate contaminants from water, soil and sediments. In this paper, two plants, Juncus effusus L. and Iris pseudacorus L. were used in an experimental study of phytoremediation of water contaminated with zinc (Zn) within bioretention systems (BRs). Plants were grown hydroponically in jars with Hoagland nutrient and under different Zn treatments (T1-T2). Four plants of each species were maintained in jars containing only Hoagland nutrient (T1), while for other Zn concentrations were: 0.5 mg/L (T2), 1 mg/L (T3), 2 mg/L (T4) and 4 mg/L (T5). Total Zn concentration in Juncus plants range from 36.2 mg/L to 264.59 mg/L for leaves and 53.20 mg/L for roots, while the concentration of Zn in Iris plants was in the ranged from 45.85 mg/L to 193.05 mg/L. There was a significant difference (p < 0.05) between the samples of Juncus effusus L. leaves and Juncus effusus L. roots as well as between the samples of Juncus effusus L. leaves and Iris pseudacorus L. roots. Juncus effusus L. plants showed significant plant growth under both, low and high Zn concentrations and a high uptake capacity of water. On the contrary, Iris pseudacorus L. plants were affected by Zn treatments, in both leaves and roots and at the end of the experiment, the decrease in the leaf biomass was noted. However, the overall results have confirmed that both plant species have the high accumulation capacity for Zn uptake and therefore, have a great potential for phytoremediation of polluted waters.
Modeling NP-Problems with Families of Extended Graph-based Reaction Systems
Authors: Kreowski Hans-Jörg , Lye Aaron 
Published: November 2023

Abstract

In this paper, we continue the investigation of graph-based reaction systems. We extend the notion by input and output states as well as admitted context sequences to model explicitly input-output relations and decision problems on the inputs. Moreover, we combine extended graph-based reaction systems into families to cover infinite input-output relations and decision problems on infinite sets of graphs. This is used to model NP-problems on graphs and reductions between them as well as to prove their correctness.
The Effects of ANRIL Polymorphisms on Colorectal Cancer, Tumor Stage, and Tumor Grade among Iranian Population
Authors: Asadi-Tarani Mina , Darashti Ahmadreza , Javadi Mohammadsaeid , rezaei Mahnaz , Saravani Mohsen , Salimi Saeedeh 
Published: November 2023

Abstract
Background: Colorectal cancer (CRC) is a type of neoplasm, developing in the colon or rectum. The exact etiology of CRC is not well known, but the role of genetic, epigenetic, and environmental factors are established in its pathogenesis. Therefore, the aim of this research was to explore the effects of ANRIL polymorphisms on the CRC and its clinical findings.
Methods and Results: The peripheral blood specimens were collected from 142 CRC patients and 225 controls referred to Milad Hospital, Tehran, Iran. PCR- RFLP method was used to analyze ANRIL rs1333040 rs10757274, rs10757274 and rs1333048 polymorphisms. The ANRIL rs1333040 polymorphism was related to a higher risk of CRC in the co-dominant, dominant, and log-additive models. ANRIL rs10757274, rs10757274, and rs1333048 polymorphisms showed no effect on CRC susceptibility. Haplotype analysis showed a higher risk of CRC in individuals carrying the CGAA haplotype of ANRIL rs1333040/ rs10757274/ rs4977574/rs1333048 polymorphisms and a lower risk of TGGA haplotype compared to TGGC haplotype. The rs1333040 polymorphism was associated with higher TNM stages (III and IV). ANRIL rs10757274 polymorphism was lower in CRC patients over the age of 50 years only in the dominant model. In addition, the rs10757274 was associated with well differentiation in CRC patients.
Conclusion, The ANRIL rs1333040 polymorphism was associated with a higher risk of CRC and higher TNM stages. ANRIL rs10757274 polymorphism was associated with the well-differentiated tumor in CRC.
An evaluation of first responders' intention to refer to post-overdose services following SHIELD training
Authors: Siddiqui Saad Tariq , Manna Anna La , Connors Elizabeth , Smith Ryan , Vance Kyle , Budesa Zach , Goulka Jeremiah , Beletsky Leo , Wood Claire A , Marotta Phillip , Winograd Rachel P. 
Published: November 2023

Abstract
Background
First responders (law enforcement officers [LEO] and Fire/Emergency Medical Services [EMS]) can play a vital prevention role, connecting overdose survivors to treatment and recovery services. This study was conducted to examine the effect of training on first responders’ intention to refer overdose survivors to treatment, syringe service, naloxone distribution, social support, and care-coordination, and whether the outcome differed by first responder profession.
Methods
First responders in Missouri were trained using the SHIELD (Safety and Health Integration in the Enforcement of Laws on Drugs) model. Trainees’ intent to refer (ITR) overdose survivors to prevention and supportive services was assessed pre- and post-training (1–5 scale). Trainees were also asked if they ever witnessed an overdose fatality. Mixed model analysis was conducted to assess change in mean ITR scores between pre- and post-training, and between profession type, while adjusting for random effects between individual trainees and baseline characteristics.
Results
Between July 2020 and January 2023, 742 first responders completed pre- and post-training surveys. SHIELD training was associated with first responders’ intention to refer, increasing overall ITR to any type of support service from 2.30 (± 0.99) to 3.90 (± 0.99), with ITR to naloxone distribution (1.83 to 3.88) and syringe exchange (1.73 to 3.69) demonstrating the greatest changes. There was a significant increase in ITR score from pre- to post-test (β = 2.15; 95% CI: 1.99, 2.30), and LEO had a higher score than Fire/EMS (0.509, 95% CI = 0.367, 0.651).
Conclusion
Training bundling occupational safety with harm reduction content is immediately effective at increasing first responders’ intention to connect overdose survivors to community substance use services. When provided with the rationale and instruction to execute referrals, first responders are amenable, and their positive response highlights the opportunity for growth in increasing referral partnerships and collaborations. Further research is necessary to assess whether ITR translates to referral behavior in the field.
Co-designing a Personalised Care Plan for patients with rectal cancer: reflections and practical learnings
Authors: Gard Grace , Oakley Jo , Serena Kelsey , Gough Karla , Harold Michael , Gray Katya , Anderson Helen , Byrne Judi , Cockwill Jo , Down Graeme , Kiossoglou George , Gibbs Peter 
Published: November 2023

Abstract
Background: Consumer involvement is considered an essential component of contemporary cancer research, with a movement towards participatory methods, to the benefit of consumers and researchers. Overall, in-depth research on participant experiences and perceptions of their co-designer role—and how these may (or may not) change during a co-design project—is limited. The purpose of this paper was to synthesise the reflective accounts of cancer consumers, project staff, and a researcher who partnered on a project to develop a personalised care plan template, with the aim of generating guidance for others looking to partner with consumers in health and medical research.
Here, our team of researchers, project staff, and consumers reflect on the experience of working together using Gibbs’ Reflective Cycle, which was completed by team members with responses then undergoing inductive data analysis.
Results: Reflections are categorised under three core themes: (1) setting up the group and building relationships (2) measuring the value of consumer involvement, and (3) potential challenges for consumer involvement. Through reflection on our experiences of co-design, our team developed and identified practical strategies that contributed to the success of our partnership. These include setting expectations as a group; having experienced consumers on the team; having regular, pre-scheduled meetings that run to time; and working to overcome challenges identified by the group such as power imbalances, time commitment, and lack of diversity.
Conclusion: These practical reflections on creating a safe and supportive environment in which genuine consumer involvement can take place could inform other institutions and researchers looking to work meaningfully with consumers in research.
An aerosol barrier system as an emerging technology for reducing airborne pathogens during singing
Authors: Karam Karam Abi , Forzani Fernando R. , Mora S. Jimena , Pyznar Gabriel , Velasquez Joseph , Elghoul Anthony Ziad , Patel Bavesh , Lowell Amelia , Forzani Erica , Schildkret David 
Published: November 2023

Abstract

In the initial stages of the COVID-19 pandemic, it became evident that singing carried a substantial risk of virus transmission. Consequently, new regulations were implemented to safeguard the population, and the adoption of singing masks emerged as a pivotal measure to curb the spread of COVID-19 during vocal performances. However, the discomfort and impediment to sensory expression caused by these masks posed significant challenges, particularly for individuals whose passions or professions revolved around singing. This study shows a novel solution to address these issues: the Aerosol Barrier System for Singing. The system features a transparent screen with an Impactor-Fan-Filter. The Impactor-Fan-Filter (IFF) is integrated into the transparent screen and strategically positioned within 1.5 feet of the singer's face. We demonstrated that the system effectively reduces the dispersion of aerosols generated during singing by over 99%. In addition, comparative sound analysis indicated that the system minimizes interference with sound waves, ensuring the preservation of sound quality. Furthermore, the transparent screen offers an unobstructed view of the singer, enhancing the overall performance experience. Our system adheres to several crucial criteria for an effective solution tailored to the needs of singers: it prioritizes safety and comfort, upholds sound quality, and facilitates an unrestricted view of the singer's entire face for the benefit of the audience, conductors, and ensemble members.
A basaloid carcinoma with multilocular thymic cyst mimicking a mediastinal teratoma: A case report
Authors: Su Chen , Zhu Xiaobo , Wang Qiang , Zhang Junjie 
Published: November 2023

Abstract
Background: Thymic tumors pose diagnostic challenges, with basaloid carcinoma being a rare and elusive variant that can mimic other mediastinal masses.
Case presentation: We present a case of a 71-year-old female initially diagnosed with a mediastinal teratoma. Imaging displayed a cystic, calcified tumor with close proximity to vital structures, suggestive of a mediastinal teratoma. The patient underwent subxiphoid thoracoscopic mediastinal tumor resection, and postoperative pathology and immunohistochemistry revealed thymic basaloid carcinoma. Fortunately, the patient had no postoperative complications, and no signs of tumor recurrence or metastasis were found during the 3-month follow-up.
Conclusions: While thymic basaloid carcinoma is infrequent, its resemblance to mediastinal teratoma complicates diagnosis and treatment planning. As we accumulate cases, a collective analysis will enhance diagnostic precision and therapeutic approaches for these intricate malignancies.
Endocrine disruptors as promoters of biosphere carcinogenic background
Authors: Belitsky G. A. , Kirsanov K. I. , Lesovaya E. A. , Zhidkova E. M. , Khitrovo I. A. , Yakubovskaya M. G. 
Published: November 2023

The main aim of the study is to analyze modern knowledge on endocrine disruptors, non-genotoxic carcinogens, contributing significantly to the total level of contamination of the biosphere by anthropogenic blastomogens.Material and Methods. For the review preparation, we analyzed articles on molecular mechanisms of the effects of endocrine disruptors, available at biomedical literature databases sciVerse scopus, pubmed, Web of science, Rsci. The review cited 65 recent publications, 21 of them being published over the past three years, 3 papers being the official documents on hazards associated with the use of endocrine disruptors, and 10 papers presenting a background to separate endocrine disruptors into the group of compounds with specific functional activity.Results. The role of endocrine disruptors involves the development of the tumors of reproductive organs. They may reveal the properties of strong agonists or antagonists disrupting the hormonal balance by inhibition of the synthesis of natural hormones, their secretion, transport, metabolism, binding or degradation. In addition, they activate alternative proliferation signaling pathways by activating g-proteincoupled receptors, estrogen-bound eRRγ or/and β-adrenergic receptors. The main mechanism of action of endocrine disruptors is the induction of epigenetic modifications, in particular, methylation/demethylation of cpg dNa islands, histone modifications and changes in expression of non-coding RNa. since the effects of endocrine disruptors are nonlinear, they can be caused by concentrations corresponding to the real content in the biosphere and detected in the umbilical blood and breast milk. In addition, they contribute to the metabolic activation of the procarcinogens, the main component of air pollution, by activation of the cytochrome p450 isoforms.Conclusion. Endocrine disruptors can underlie the development of tumors of hormone-dependent organs both at direct and transplacental exposure.
Systemic lymphangitic carcinomatosis from unknown primary cancer mimicking lung disease in a new coronavirus infection (COVID-19): a case report
Authors: Andryukhova E. S. , Krakhmal N. V. , Tashireva L. A. , Vtorushin S. V. , Zavyalova M. V. , Perelmuter V. M. 
Published: November 2023

lymphangitic carcinomatosis is characterized by the spread of cancer cells through pulmonary lymphatic vessels, which results in secondary interstitial inflammation. The diagnosis of lymphangitic carcinomatosis is challenging due to nonspecific clinical symptoms and radiological findings that similar to those of interstitial lung disease.The purpose of the study was to demonstrate difficulties in the diagnosis of lymphangitic carcinomatosis with a systemic dissemination from unknown primary site. Case presentation. We report on a case of lymphangitic carcinomatosis from cancer of unknown primary origin with systemic involvement of internal organs imitating pulmonary disease caused by coVid-19. patient K., 58 years old, was treated for 12 bed-days in therapy departments with the diagnosis of bilateral viral coVid-19 pneumonia. clinical, laboratory and instrumental data were nonspecific. despite treatment, heart failure and kidney disease progressed to terminal stages, leading to the death of the patient. Autopsy revealed systemic lymphangitic carcinomatosis from cancer of unknown primary origin with involvement of the lungs, heart, liver, pancreas, spleen, kidneys and adrenal glands. lymphangitic carcinomatosis mimicked interstitial lung disease in a novel coronavirus infection coVid-19. metastasis to the heart mimicked coronary disease, and metastases to the kidneys led to acute kidney failure, which along with acute respiratory and heart failure caused the death of the patient.Conclusion. lymphangitic carcinomatosis, which does not have specific clinical manifestations, is able to mimic interstitial lung diseases, including a new coronavirus infection. cancer of unknown primary and multiple visceral metastases in this case confirm the concept of the independence of different types of tumor progression.
Cancer care to the population of Russia in 2022
Authors: Shakhzadova A. O. , Starinsky V. V. , Lisichnikova I. V. 
Published: November 2023

Objective: to analyze cancer statistics in Russia as a whole, as well as in individual regions of the Russian Federation.Material and Methods. Based on data from the state medical statistics according to the form No. 7 “information on malignant neoplasms for 2022” the crude and standardized rates, standard error of crude and standardized rates, confidence intervals (ci) for 2022, and the qualitative parameters of cancer care were calculated.Results. in 2022, 624,835 new cancer cases were detected in the Russian Federation (283,179 in men and 341,656 in women), in increase of 7.6 % compared to 2021 (in 2021: 580415), and decrease of 2.4 % compared to 2019 (in 2019: 640391). in 2022, the crude incidence rate was 425.89 ± 0.54 per 100,000 population of Russia (ci: 424.83–426.95 per 100,000 population), which was 7.0 % higher than that in 2021 (in 2021 – 397.91 ± 0.54 per 100,000 population) but 2.4 % lower than in 2019 (in 2019 – 436.34 ± 0.52 per 100,000 population). the standardized incidence rate was 236.47 ± 0.32 per 100,000 population (ci: 235.84–237.10 per 100,000 population), which was 5.2 % higher compared to that observed in 2021 (in 2021 – 224.87 ± 0.32 per 100,000 population) but 5.2 % lower than in 2019 (in 2019 – 249.54 ± 0.33 per 100,000 population). the prevalence rate of cancer in 2022 was 2,742.4 per 100,000 population of Russia, an increase in the prevalence rate over 10 years was 33.9 %.Conclusion. Сancer care in the Russian Federation in 2022 was provided at the proper level. there is a positive trend in the early detection of cancer, which partly influences the reduction in the one-year mortality rate.
Minimally-invasive and non-invasive methods of thermal destruction in the treatment of patients with aggressive fibromatosis
Authors: Moskvicheva L. I. 
Published: November 2023

The purpose of the study was to characterize various methods of local physical destruction used in the treatment of patients with aggressive fibromatosis and demonstrate international experience of their use.Material and Methods. literature search was conducted in the electronic databases Rsci (Russian science citation index) and NcBi (National centre for Biotechnology information) in the interval time between 2002 and 2022. The review was devoted to the thermal ablation modalities (radiofrequency, microwave ablation, cryodestruction, high-intensity focused ultrasound ablations) used in therapy of patients with desmoid fibromas of various locations, as well as their safety and efficacy.Results. The review presents the current data on safety and efficacy of minimally-invasive and non-invasive methods of hypo- and hyperthermic local destruction in patients with aggressive fibromatosis, gives the characteristics of exposure and biological effects when performing radiofrequency and microwave ablation, cryodestruction, high-intensity focused ultrasound therapy, describes the main limitations of the methods, indications and contraindications for their application, as well as the methods of prevention of the development of desmoid fibromas.Conclusion. The described methods of local destruction are used in clinical practice mainly for palliative and symptomatic purposes, in case of persistent tumor growth or recurrence, ineffectiveness of other treatment options or contraindications to them due to concomitant somatic pathology or functional status of the patient. Inclusion of these methods in the treatment plan of patients with aggressive fibromatosis can contribute to the reduction of pain syndrome, improvement of functional status of patients as well as long survival with no evidence of tumor progression.
Development of Wheatgrass (Triticum aestivum) Extract Loaded Solid
Lipid Nanoparticles using Central Composite Design and its
Characterization- Its In-vitro Anti-cancer Activity
Authors: Minocha Neha , Pandey Parijat , Sharma Nidhi , Saini Sangita 
Published: November 2023

Background:
The prevalence of cancer is around the world and is identified as a multifactorial
ailment. One of the most common causes of cancer in the world is oxidative stress, and
this can be overcome by taking herbal plant wheatgrass in any form. As colloidal carriers with
particle sizes of 50-1,000nm, Solid Lipid Nanoparticles (SLNs) combine the benefits of liposomes,
emulsions, and other colloidal systems to deliver drugs at their targets.

Objective:
Aim and objective of the present work is to formulate wheatgrass extract loaded solid
lipid nanoparticles using Central Composite design and to investigate the effect of formulation
variables. Using hot homoginization method, the present work aimed to formulate wheatgrass
loaded chitosan solid lipid nanoparticles using central composite design and to evaluate the extract
potential to treat breast cancer on MCF-7 cell line.

Methods:
This study investigated the effect of three formulation variables on particle size, namely
the sodium alginate concentration, the calcium carbonate concentration, and the homogination
time. Extraction of wheatgrass was done in soxhlet extractor, using methanolic extract. The hot
homogenization technique was used to prepare Triticum aestivum extract loaded solid lipid nanoparticles
(SLNs).

Result:
For CCD, all formulations were analyzed for particle size, which ranged from 362.5 to
933.8 nm, and for polydispersity index, which ranged from 0.137 to 5.799. Batch code SLN-6
was found to be finest suitable because of maximum loading capacity of 67.76 ±0.17 % (w/w),
maximum entrapment efficiency of 65.81 ± 0.11 % (w/w) and minimum particle size of 362.5nm
by using sodium alginate as surface stabilizer at homogenization time ~ 5 min and having maximum
percentage yield of 43.66%.

Conclusion:
During characterization studies and MCF-6 cell line studies, it was found that batch
code SLN-6 was found to be finest suitable and wheatgrass has anti-oxidant potential, and potent
against breast cancer.
A Review on Nanostructured Lipid Carriers as Promising Drug Delivery
Vehicle to Target Various Cancers via Oral Route: A Step towards
“Chemotherapy at Home”
Authors: Quadir Sheikh Shahnawaz , Joshi Garima , Saharan Vinod , Mangesh Harish , Choudhary Deepak , Yadav Khushwant , Jain Chandra Prakash , Chauhan Lalit Singh 
Published: November 2023

Abstract:
Oral drug administration is largely preferred owing to enhanced patient compliance, convenience of self-intake of dose, non-invasiveness, and low manufacturing cost. Cancer is a condition that starts with aberrant cell division at an uncontrolled rate. The clinical effectiveness of many anticancer drugs is limited by their physicochemical characteristics and physiological circumstances in the GI tract. Nanostructured lipid carriers have the potential to enhance the bio-availability of anticancer drugs by entrapping them. The NLCs, by virtue of their nanosize and their biocompatibility, can bypass the first-pass metabolism and be taken up by M cells of Peyer’s patches to deliver the drug to the deeper tumours. The proposed review highlights the potential of NLCs in oral drug delivery for the management of various cancers. It discusses various strategies, method of preparation, mechanism of uptake, and their applications in the treatment of cancer via oral delivery. Further, it explains the recent advances and future perspectives.