bluuebunny/crossref_metadata_2025_split huggingface dataset:
A regional virtual case discussion forum in pediatric oncology: Experience of the Pediatric Oncology East and Mediterranean Group
Authors: Noun Dolly , Obeid Anas , Belgaumi Asim , Sidhom Iman , Jadiry Mazin Al , Al‐Saeed Raghad , Khalifa Nisreen , Trehan Amita , Ghanem Khaled , AbdelHafeez Hafeez , Rodriguez‐Galindo Carlos , Jeha Sima , Saab Raya 
Published: December 2023

AbstractBackgroundThe Pediatric Oncology East and Mediterranean (POEM) group that aims to share expertise among pediatric oncology providers across the Middle East, North Africa, and East Asia region initiated a virtual Case Discussion Forum (CDF) in 2013.MethodsMeeting records from September 2013 till June 2021 were reviewed. Detailed minutes were available starting August 2016; case data were analyzed including diagnoses, purpose of presentation and recommendations. A 38‐item survey assessing perception of benefits, challenges, and opportunities of the forum was distributed to members of the POEM group and results analyzed.ResultsA total of 140 cases were presented from 14 countries. After August 2016, 67 cases were presented, and those were analyzed regarding reasons for discussion, barriers, and recommendations. Details are presented in this report, and the most common challenges identified were related to histopathologic/molecular diagnosis (24%), imaging interpretation (18%), resource limitations (12%), and surgical difficulties (9%). A survey was distributed to all POEM members in 28 countries, and 76 responded. The main benefit reported was the provision of recommendations regarding treatment and evaluation, while the main challenges reported were time zone difference and workload. Recognized opportunities included conducting regionally relevant research studies based on clinical problems identified during discussions, and setting guidelines for resource‐adapted treatment regimens.ConclusionsThe POEM CDF identified areas for multi‐institutional regional studies and led to a twinning project between two centers in the region for improving diagnostic infrastructure. Such forums can identify specific resource limitations in pediatric cancer and direct efforts for targeted capacity building.
Diffuse interstitial lung disease in a male fetus with periventricular nodular heterotopia and filamin A mosaic variant
Authors: Desnous Beatrice , Carles Guillaume , Riccardi Florence , Stremler Nathalie , Baravalle Melissa , El‐Louali Fedouah , Testud Benoit , Milh Mathieu 
Published: December 2023

AbstractBackgroundMost periventricular nodular heterotopias (PNHs) are associated with a mutation in the filamin A (FLNA) gene in Xq28. This condition is associated with cardiovascular malformations, connective tissue abnormalities, epilepsy, and intellectual deficiency of varying severity.Materials and MethodsWe report a new FLNA gene mutation in a male patient associated with PNH and diffuse interstitial lung disease.ResultsA 23‐year‐old woman was referred at 31 gestational weeks to evaluate a suspected mega cisterna magna and ventricular septal defect with atrioventricular valve alignment in a male fetus. The fetal magnetic resonance imaging showed PNH associated with corpus callosum dysgenesis and a mega cisterna magna. At 2 months of age, the infant was diagnosed with severe respiratory distress with hypoxemia. A chest CT scan demonstrated a diffuse interstitial lung pattern with emphysema, multiple atelectasis foci, and signs of pulmonary hypertension. Rapid worsening led to his death at 4 months. Targeted sequencing of the FLNA gene identified a de novo hemizygous variant in 75% mosaic in lymphocyte cells, resulting in incomplete FLNA function loss.Discussion & ConclusionOn the diagnosis of antenatal PNH, the possibility of such lung involvement should be considered in the prognostic evaluation during prenatal counseling.
Triple‐chain segments regulation enable shape memory and photo deformation of smart polyimide
Authors: Wan Baoquan , Pu Tongtong , Xing Yunqi , Zha Jun‐Wei 
Published: December 2023

AbstractIntegration of controllable deformation with excellent thermal stability, mechanical, and insulation properties can greatly expand the versatility of smart polyimides (PIs). However, the unique molecular structure of PI makes it difficult for its molecular chain to move, which is not conducive to the reversible transformation of highly stable PI under environmental conditions. In this study, a PI film integrating shape memory and photo deformation is prepared by constructing a chemical network with PI oligomer as the hard, hexamethylene diisocyanate (HDI) as the soft, and azobenzene as the functional chain segment. The PI films still have a high glass transition temperature Tg ~ 225°C, a high Young's modulus E ~ 3.5 GPa, and a good breakdown strength Eb ~ 176 kV/mm. Moreover, as the network point of the chemical network, the trifunctional crosslinking agent makes the PI produce the shape memory effect induced by light and heat. UV light can drive crosslinked photoresponsivity PI film to have special shape transformation under specific conditions, using azobenzene as photoresponsivity group. This study provides a new idea for the preparation of multifunctional PI, which makes it potentially applicable in the field of smart electric and electronic engineering.
Structural flexibility and heterogeneity of recombinant human glial fibrillary acidic protein (GFAP)
Authors: Gogishvili Dea , Illes‐Toth Eva , Harris Matthew J. , Hopley Christopher , Teunissen Charlotte E. , Abeln Sanne 
Published: December 2023

AbstractGlial fibrillary acidic protein (GFAP) is a promising biomarker for brain and spinal cord disorders. Recent studies have highlighted the differences in the reliability of GFAP measurements in different biological matrices. The reason for these discrepancies is poorly understood as our knowledge of the protein's 3‐dimensional conformation, proteoforms, and aggregation remains limited. Here, we investigate the structural properties of GFAP under different conditions. For this, we characterized recombinant GFAP proteins from various suppliers and applied hydrogen‐deuterium exchange mass spectrometry (HDX‐MS) to provide a snapshot of the conformational dynamics of GFAP in artificial cerebrospinal fluid (aCSF) compared to the phosphate buffer. Our findings indicate that recombinant GFAP exists in various conformational species. Furthermore, we show that GFAP dimers remained intact under denaturing conditions. HDX‐MS experiments show an overall decrease in H‐bonding and an increase in solvent accessibility of GFAP in aCSF compared to the phosphate buffer, with clear indications of mixed EX2 and EX1 kinetics. To understand possible structural interface regions and the evolutionary conservation profiles, we combined HDX‐MS results with the predicted GFAP‐dimer structure by AlphaFold‐Multimer. We found that deprotected regions with high structural flexibility in aCSF overlap with predicted conserved dimeric 1B and 2B domain interfaces. Structural property predictions combined with the HDX data show an overall deprotection and signatures of aggregation in aCSF. We anticipate that the outcomes of this research will contribute to a deeper understanding of the structural flexibility of GFAP and ultimately shed light on its behavior in different biological matrices.
Nested extended state observer design for uncertain nonlinear systems under time‐varying disturbance
Authors: Su Guanghao , Wang Zhenlei 
Published: December 2023

AbstractWith rising demands on system performance and reliability in engineering practice, researchers are increasingly interested in disturbance rejection control, of which state and disturbance observation is the essential element. The extended state observer (ESO, or extended high‐gain observer) is extensively utilized to compensate disturbance, nevertheless, the neglect of lumped disturbance's first derivative and peak phenomenon in classical ESO design impose obstacles to further promotion. In this article, nested ESO (NestedESO) is proposed to estimate states and disturbance simultaneously for general uncertain nonlinear systems under time‐varying disturbance. In NestedESO framework, low‐gain generalized ESO is implemented to obtain a rough estimation of lumped disturbance in the first stage. Then, a novel proportion‐filter‐derivative disturbance estimation refinement mechanism is introduced to provide accurate disturbance estimation. With refined disturbance estimation, modified Luenburger observer is put forward to reconstruct state. Besides, extension to sampled‐data systems is investigated to adapt the networked signal transmission scenario. Numerical examples are given to illustrate the validity and effectiveness of the proposed method.
Conversion of Photoluminescence Blinking Types in Single Colloidal Quantum Dots
Authors: Yang Changgang , Li Yang , Hou Xiaoqi , Zhang Mi , Zhang Guofeng , Li Bin , Guo Wenli , Han Xue , Bai Xiuqing , Li Jialu , Chen Ruiyun , Qin Chengbing , Hu Jianyong , Xiao Liantuan , Jia Suotang 
Published: December 2023

AbstractAlmost all colloidal quantum dots (QDs) exhibit undesired photoluminescence (PL) blinking, which poses a significant obstacle to their use in numerous luminescence applications. An in‐depth study of the blinking behavior, along with the associated mechanisms, can provide critical opportunities for fabricating high‐quality QDs for diverse applications. Here the blinking of a large series of colloidal QDs is investigated with different surface ligands, particle sizes, shell thicknesses, and compositions. It is found that the blinking behavior of single alloyed CdSe/ZnS QDs with a shell thickness of up to 2 nm undergoes an irreversible conversion from Auger‐blinking to band‐edge carrier blinking (BC‐blinking). Contrastingly, single perovskite QDs with particle sizes smaller than their Bohr diameters exhibit reversible conversion between BC‐blinking and more pronounced Auger‐blinking. Changes in the effective trapping sites under different excitation conditions are found to be responsible for the blinking type conversions. Additionally, changes in shell thickness and particle size of QDs have a significant effect on the blinking type conversions due to altered wavefunction overlap between excitons and effective trapping sites. This study elucidates the discrepancies in the blinking behavior of various QD samples observed in previous reports and provides deeper understanding of the mechanisms underlying diverse types of blinking.
Evolution of High‐Index Facets Pt Nanocrystals Induced by N‐Defective Sites in the Integrated Electrode for Enhanced Methanol Oxidation
Authors: Li Yuhui , Yang Jirong , Liu Feng , Shi Chaoyang , Zhu Enze , Yin Shubiao , Yu Jie , Xu Mingli 
Published: December 2023

AbstractHighly efficient and durable Pt electrocatalysts are the key to boost the performance of fuel cells. The high‐index facets (HIF) Pt nanocrystals are regarded as excellent catalytic activity and stability catalysts. However, nucleation, growth and evolution of high‐index facets Pt nanocrystals induced by defective sites is still a challenge. In this work, tetrahexahedron (THH) and hexactahedron (HOH) Pt nanocrystals are synthesized, which are loaded on the nitrogen‐doped reduced graphene oxide (N‐rGO) support of the integrated electrodes by the square wave pulse method. Experimental investigations and density functional theory (DFT) calculations are conducted to analyze the growth and evolution mechanism of HIF Pt nanocrystals on the graphene‐derived carbon supports. It shows that the H adsorption on the N‐rGO/CFP support can induce evolution of Pt nanocrystals. Moreover, the N‐defective sites on the surface of N‐rGO can lead to a slower growth of Pt nanocrystals than that on the surface of reduced graphene oxide (rGO). Pt/N‐rGO/CFP (20 min) shows the highest specific activity in methanol oxidation, which is 1.5 times higher than that of commercial Pt/C. This research paves the way on the design and synthesis of HIF Pt nanocrystal using graphene‐derived carbon materials as substrates in the future.
Challenges and Strategies of Aluminum Anodes for High‐Performance Aluminum–Air Batteries
Authors: Zhang Yuxin , Lv Chaonan , Zhu Yuanxin , Kuang Jialin , Wang Haiyan , Li Yixin , Tang Yougen 
Published: December 2023

AbstractAluminum–air battery (AAB) is a promising candidate for next‐generation energy storage/conversion systems due to its cost‐effectiveness and impressive theoretical energy density of 8100 Wh kg−1, surpassing that of lithium‐ion batteries. Nonetheless, the practical applicability of AABs is hampered by the occurrence of serious self‐corrosion side reactions and substantial capacity loss, resulting in suboptimal anode utilization. Consequently, improving the anode utilization to facilitate the construction of high‐performance AABs have attracted widespread attention. Herein, the fundamentals and strategies to enhance aluminum anode utilization are reviewed from modifications of aluminum anodes and electrolytes. This comprehensive review may provide a scientific tool for the development of novel AABs in the future.
How to early integrate operational diagnosis objectives in model‐driven engineering processes: A methodological proposal based on fault and behavior trees
Authors: Christofi Nikolena , Baron Claude , Pucel Xavier , Pantel Marc , Canu David , Ducamp Christophe 
Published: December 2023

AbstractTo help operators perform their diagnosis tasks more efficiently, the authors put forward a novel methodology introducing a new type of model, dedicated to operations, co‐created in parallel with the design models, in the preliminary stages of system development, using the language semantics of behavior trees. In this paper, the authors present the need for this new model type as expressed by the industry and justify their choice for adopting behavior trees, while illustrating in detail the proposed methodology.
Perineal myiasis caused by Wohlfahrtia magnifica in mares in central France
Authors: Bouquet Julien 
Published: December 2023

AbstractThree cases of Wohlfahrtia magnifica perineal myiasis on mares living in the Indre Department (central France) are reported. W. magnifica, whose geographical dispersion towards the plains has been known since the 1980s, continues its progression in France. Altitude is not a limiting factor for this fly, unlike climate. However, we assume that climate change and its ecological consequences, associated with the natural resistance of the maggot and commercial transactions, will not be an obstacle to the W. magnifica development in France.
An Assessment of the Validity of Damköhler’s Hypotheses for Different Choices of Reaction Progress Variable in Homogenous Mixture Moderate or Intense Low-Oxygen Dilution (MILD) Combustion
Authors: Awad Hazem S. A. M. , Abo-Amsha Khalil , Ahmed Umair , Chakraborty Nilanjan 
Published: December 2023

AbstractThe applicability of Damköhler’s hypotheses for homogenous mixture (i.e. constant equivalence ratio) moderate or intense low-oxygen dilution (MILD) combustion processes (with methane as the fuel) has been assessed using three-dimensional direct numerical simulation data with a skeletal mechanism. Two homogeneous MILD combustion cases with different levels of $${{\text{O}}}_{2}$$

O
2

concentration (4.8% and 3.5% by volume) and different turbulence intensities have been investigated to analyse the influence of dilution level, turbulence intensity and the choice of the reaction progress variable definition (i.e. different choices of major species for turbulent burning velocity and flame surface area evaluations) on the applicability of Damköhler’s hypotheses in MILD combustion. It has been found that the normalized volume-integrated burning rate remains of the same order of magnitude as that of the normalized flame surface area only for the reaction progress variable definition based on a species mass fraction which has a Lewis number close to unity (e.g. $${{\text{CH}}}_{4}$$

CH
4

) but the level of applicability deteriorates when the Lewis number of the species mass fraction, based on which the reaction progress variable is defined, deviates significantly from unity (e.g. $${{\text{CO}}}_{2}$$

CO
2

). Moreover, it has been demonstrated that the flame surface area calculation from the OH mole fraction-based information can lead to significant departures from Damköhler’s first hypothesis. It is also found that the relative magnitudes of normalised volume-integrated burning rate and normalised flame surface area are significantly affected by the level of dilution and the choice of the reaction progress variable definition. Damköhler’s second hypothesis, which provides a relation between the normalised turbulent burning velocity and the ratio of turbulent to molecular diffusivities, has been found to hold in an order of magnitude sense in homogeneous mixture MILD combustion only for the reaction progress variable definition based on species that has a Lewis number close to unity (e.g. $${{\text{CH}}}_{4}$$

CH
4

) but the level of disagreement increases as the Lewis number of the reaction progress variable deviates significantly from unity (e.g. $${{\text{CO}}}_{2}$$

CO
2

).
QTL Mapping and Genetic Map for the Ornamental Sunflower in China
Authors: Liu Jixia , Shan Junjian , Wang Ping 
Published: December 2023

AbstractQuantitative trait locus (QTL) mapping and genetic map are of great significance for ornamental sunflowers in China. In this study, a total of 956.50 Mbp data were obtained, the average Q30 was 93.76%, the average GC content was 42.43%, and the GC distribution of the parents and F2 population of the ornamental sunflowers was normal. At the same time, the double-end comparison efficiency of control data was 90.28%, and the enzyme digestion efficiency was 92.01%. The Specific-Locus Amplified Fragment (SLAF) library construction was normal. Furthermore, a total of 734,893 SLAF markers were obtained, among which 127,855 were polymorphic SLAF markers and 38,908 could be used for genetic map construction, and the effective polymorphism of the parents was 5.29%. Moreover, we constructed a total of 17 linkage groups, with 6181 markers in the QTL mapping, the total map distance was 2608.66 cM, the marker integrity in the figure above was 99%, the proportion of double exchange was 0.05, the sequencing depth of the parents was 42.455 × , and the progeny was 9.24 × . The relationship of traits (plant height, stem diameter, disk diameter, number of petals, leaf number, stigma color, petal color, petiole color) and QTL mapping was closely related to show the best of ornamental effect.
Currency Carry, Momentum, and Global Interest Rate Volatility
Authors: Zeng Ming 
Published: December 2023

Abstract
Returns to currency carry and momentum compensate for the risk of global interest rate volatility (IRV), with risk exposures explaining 92% of the cross-sectional return variations. This unified explanation stems from its impact on foreign exchange intermediaries. An intermediary-based exchange rate model shows that a higher global IRV increases the uncertainty of future risk-taking and tightens current financial constraints. Position unwinding triggers loss of carry and momentum. Additional empirical results confirm this economic channel. Global IRV risk is also negatively priced in other currency strategies and momentum. The explanatory power is not driven by existing measures of uncertainty or intermediary constraints.
Identification of candidate genes involved with dicamba resistance in waterhemp (Amaranthus tuberculatus) via transcriptomics analyses
Authors: Bobadilla Lucas K. , Tranel Patrick J. 
Published: December 2023

AbstractWaterhemp [Amaranthus tuberculatus (Moq.) Sauer] is one of the most troublesome weeds in the United States. An A. tuberculatus population (CHR) was identified in Illinois, USA, as resistant to herbicides from six different site-of-action groups. Recently, the same population was also recognized as dicamba resistant. This study aimed to identify key resistance genes and the putative dicamba resistance mechanism in A. tuberculatus via transcriptomics analysis. Multiple differentially expressed (DE) genes and co-expression gene modules were identified as associated with dicamba resistance. Specifically, genes encoding glutathione S-transferases (GSTs), ATP-binding cassette transporters, peroxidases, and uridine diphosphate (UDP)-glycosyltransferases (UGTs) were identified. Results indicated enhanced oxidative stress tolerance as the primary mechanism for reducing dicamba toxicity. Results also point to potential glycosylation via UGTs and conjugation via GSTs of dicamba and its by-products. This is the first transcriptomics characterization of dicamba resistance in A. tuberculatus. Multiple non-target-site resistance genes were identified, indicating a cross-resistance pattern in the CHR population leading to a putative-enhanced oxidative stress response. Regions of multiple DE genes (i.e., genomic hot spots) across the A. tuberculatus genome corroborate previous results and potentially add to the complexity of non-target-site resistance traits.
Ionospheric Response to Solar EUV Radiation Variations Using GOLD Observations and the CTIPe Model
Authors: Vaishnav Rajesh , Jacobi Christoph , Berdermann Jens , Schmölter Erik , Dühnen Hanna , Codrescu Mihail 
Published: December 2023

AbstractTo understand the global response of thermospheric‐ionospheric (TI) parameters to variations in solar irradiance measurements from the Global‐Scale Observations of the Limb and Disk (GOLD) ultraviolet imaging spectrograph, solar radio flux F10.7, predictions from the Coupled Thermosphere Ionosphere Plasmasphere electrodynamics (CTIPe) model, and International Global Navigation Satellite System Service total electron content maps (TEC) have been used. Various parameters such as GOLD O/N2, O2, and the nighttime peak electron density (Nmax) have been compared with the CTIPe model simulations. The GOLD observed Nmax shows a number of significant features including a winter anomaly and an equatorial ionization anomaly. The comparison with solar proxies showed that the GOLD QEUV correlates very well with the EUV observations compared to the F10.7 index. The study also examined the relationship between the solar proxies and Nmax on different time scales and found that Nmax responded significantly to QEUV at both medium‐ and long‐term timescales. Furthermore, a low correlation between Nmax in the equatorial region and solar proxies was found. A delayed ionospheric TEC response against solar flux variations within the 27‐day solar rotation was investigated. This ionospheric delay of TEC with respect to solar flux was observed to be less than 1 day, which was reproduced in model simulations. The current study has shown that the GOLD observations can be used to investigate the delayed ionospheric response and to gain a better understanding of the influence of solar activity on the TI system.