bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toxoplasmosis and Chlamydophilosis in Small Ruminant Farms in Cameroon: Knowledge, Attitudes, Practices and Perception of Zoonotic Risks of Farmers
Authors: Nankam Roland Chimi , Kouamo Justin , Kouam Michel Alain Simo , FOTSAC Muller DZOUSSE , DEMBENG Raphael CHERMAPI , KOUENGOUA Armelle Prudence KOUENGOUA , Ngoula Ferdinand 
Published: November 2023

Abstract

Zoonotic abortive diseases represent a significant health and economic risk for national public health. This cross-sectional survey was conducted from April to October 2021 among 200 selected small ruminant farmers in the three northern regions of Cameroon. Data collection was done through questionnaires administered by exchange with the herder and responses were coded and recorded on an Excel spreadsheet. The data were then analyzed with R software, version 2.13.0. An ANOVA test was used to assess significant differences in mean of Knowledge, Attitudes, Practices and Perception of zoonotic risks (KAPP) scores between regions. Pearson correlations were used to calculate the association between KAPP scores within regions. Small ruminant farmers surveyed had low mean scores for knowledge of abortive Toxoplasmosis and Chlamydophilosis(0.1 ± 0.2), desirable attitude (0.32 ± 0.07), appropriate practice (0.36 ± 0.13) in managing abortion, and positive perception of zoonotic risks of Toxoplasmosis and Chlamydophilosisin small ruminants (0.12 ± 0.33), respectively. KAPP was significantly (p<0.01) and positively associated with knowledge (r=0.98) and risk perception (r=0.99). However, attitudes (r=0.06), practices (r=0.05) and risk perception of toxoplasmosis (r=0.07) and Chlamydophilosis (r=0.08) were not associated with farmers' knowledge. This study revealed significant knowledge gaps, low levels of desired attitudes, and high-risk behavioral practices. These results therefore call for capacity building of health professionals and farmers to better integrate the One Health concept in the management of neglected zoonotic diseases.
Risk factors of postoperative C5 Palsy after open-door laminoplasty with titanium plates
Authors: Doi Kazuma , Tani Satoshi , Mizuno Junichi 
Published: November 2023

Abstract
Study Design: A retrospective study
Objectives:C5 palsy is one of the well-known side effects of cervical posterior decompression or fusion surgery, and it might be caused by multifactorial etiology. Examining risk factors for postoperative C5 palsy is the goal of this investigation.
Setting:General Hospital in Kanagawa, Japan
Methods:An analysis was performed on 132 adult patients who underwent open-door cervical laminoplasty for degenerative diseases in our single center between January 2015 and October 2021. Eight patients (6.1%) developed C5 palsy, although seven of the eight cases made a full recovery without additional surgery. We compared the demographic and radiographic traits of the C5 palsy group with those of the non-C5 palsy group.
Results:In the C5 palsy group, the preoperative T2-high lesion on magnetic resonance imaging (MRI) was present in 62.5% whereas it was positive in
20.3% in the non-C5 palsy group (p=0.021). Besides, the C4/5 foraminal minimal distance on the open side was 2.42 ± 0.84 mm in the C5 palsy group whereas it was 3.58 ± 0.94 mm in the non-C5 palsy group (p = 0.001).
Conclusion:The preoperative T2-high lesion on MRI and C4/5 foraminal stenosis on the open side are risk factors for postoperative C5 palsy following open-door laminoplasty with titanium plates.
Mirvetuximab Soravtansine in Solid Tumors: A Systematic Review and Meta-Analysis
Authors: Rehim Shamsnur , Yuan Shuang , Wang Hongjing 
Published: November 2023

Abstract
Background: Mirvetuximab Soravtansine (MIRV) is a promising antibody‒drug conjugate (ADC) that targets folate receptor alpha (FRα), which is overexpressed in several types of solid tumors. In November 2022, MIRV was approved in the USA for the treatment of adult patients with FRα-positive, platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer who received 1-3 prior systemic treatment regimens. Therefore, high-quality evidence for its efficacy and safety in different cancers is urgently needed.
Methods: A systematic search (e.g., PubMed, Embase, Web Of Science, Cochrane Library) was conducted to identify all relevant clinical trials of MIRV alone or in combination with chemo- and/or target-therapies in solid tumors. The primary end-point was median progression-free survival (mPFS). The secondary endpoints were the overall response rate (ORR) and adverse effects (AEs). A random-effects model was applied.
Results: The study included nine research studies with a total of 682 patients. The pooled mPFS and pooled ORR were 6.70 months (95% CI 4.54–8.86,I2=96.21%) and 36% (95% CI: 28% to 44%, I2=76.79%), respectively. Significant differences were observed among intervention regimens and response to platinum. The pooled mPFS of MIRV monotherapy and MIRV+ BEV combined therapy was 4.28 (95% CI 3.90–4.65, I2=0.00%) and 7.78 (95% CI 6.62-8.95, I2=0.00%), respectively. The pooled ORRs of MIRV monotherapy and MIRV+BEV combined therapy were 25% (95% CI 21%–29%, I2=25.20%) and 43% (95% CI 36%–50%, I2=0.01%), respectively. The pooled ORRs of the platinum-sensitive, platinum-resistant groups were 59% (95% CI 36%–81%, I2=61.88%), 33% (95% CI 25%–40%, I2=69.73%), respectively. In addition, we conducted supplementary subgroup analyses to explore the influence of FRα receptor expression levels and the number of prior treatments on treatment outcomes. The most common adverse effects were blurred vision (45.20%), nausea (40.13%), diarrhea (39.52%), fatigue (33.84%) and keratopathy (31.20%).
Conclusions: MIRV has significant therapeutic effects in solid tumors, especially when combined with BEV. In platinum-tolerant tumors, the efficacy of MIRV is also considerable. Overall, MIRV is relatively safe in solid tumors, and adverse reactions are relatively rare and mild.
Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease
Authors: Pagliarini David , Sung Andrew , Guerra Rachel , Steenberge Laura , Alston Charlotte , Murayama Kei , Okazaki Yasushi , Shimura Masaru , Prokisch Holger , Ghezzi Daniele , Torraco Alessandra , Carrozzo Rosalba , ROTIG Agnes , Taylor Robert , Keck James 
Published: November 2023

Abstract

Isolated complex I (CI) deficiencies are a major cause of primary mitochondrial disease. Two-thirds of CI deficiencies arise from defects in CI assembly factors (CIAFs) that are not part of the CI holoenzyme. The biochemistry of CIAFs is poorly defined, making their role in CI assembly unclear and confounding interpretation of potential disease-causing genetic variants. To address these challenges, we devised a deep mutational scanning approach to systematically assess the function of thousands of NDUFAF6 genetic variants. Guided by these data, biochemical analyses, and cross-linking mass spectrometry, we discovered that the CIAF NDUFAF6 facilitates incorporation of NDUFS8 into CI and reveal that NDUFS8 overexpression rectifies NDUFAF6 deficiency. Our data further provide experimental support of pathogenicity for seven novel NDUFAF6 variants associated with human pathology and add phenotypic annotation for 5,675 additional variants. Overall, our work defines the function of NDUFAF6 and provides a comprehensive clinical resource for diagnosing NDUFAF6-related diseases.
Assessment of variability of sea surface salinity using integrated all-weather satellite data in a tropical coast (Nigerian coastal zone)
Authors: Ajibola-James Opeyemi , Okeke Francis , Ojinnaka Oliver 
Published: November 2023

Abstract
The tropical coasts, particularly the Nigerian coastal zone has been traditionally undersampled, and understudied using appropriate remote sensing technique. In spite of the disparity in the spatial scales of accessible all-weather satellite sea surface salinity (SSS) datasets, their integrated applications for baseline, and SSS variability studies coupled with the implications in such coastal zone at local scale are crucial for supporting relevant decisions. We utilized integrated SSS datasets from Aquarius/Satélite de Aplicaciones Científicas (SAC)-D (Aquarius) and Soil Moisture Active Passive mission (SMAP) satellite products in this study. We determine their accuracy. We assess the interannual and seasonal variability of the monthly SSS (Jan., 2012-Dec., 2021); and determine their potential implications for changes in the freshwater flux (FWF) and tidal rivers discharge. We show RMSD of 0.1100 psu and 0.1236 psu for Aquarius and SMAP respectively. We show Coefficient of Variation (CV) of 0.66% and 2.96% for the interannual SSS variability (iSSSv) and the seasonal SSS variability (sSSSv) respectively. We show that the negative average annual percentage change (NAAPC, -0.06%) and the negative average seasonal percentage change (NASPC, -0.21%) imply the predominance of net positive FWF, and of relatively high freshwater discharge into the coastal zone. The results suggest relatively stable iSSSv; and low risk of upstream seawater intrusion from the Nigerian coastal zone. Despite the difference in spatial resolution of the two datasets, the results further suggest a relatively accurate integrated dataset for assessing SSS variability; and for monitoring SSS for the risk of upstream seawater intrusion in the tropics.
Fostering the waste management: Environmental-resource interacting attribute
Authors: Zeng Xianlai , Li Jinhui , Huang Wenbo 
Published: November 2023

Abstract

Increasing waste management is one of the grand challenges for our humans. The environmental-resource interacting attribute (ERIA) quantifies the difficulties of resource recovery and environmental impact elimination in waste processes and provides important insights into the recycling potential and environmental burden of waste. We measured ERIA in detail in twelve waste categories for management pathways. Findings reveal considerable variability in ERIA across waste types and treatment paths, with copper slag exhibiting the highest and most balanced ERIA, implying easy treatment. The flow of information processed through downcycling pathways presents the highest ERIA and leans toward resource attributes. ERIA variability is significantly influenced by statistical entropy, rank, and removal rank of waste elements. We suggest classifying effective waste based on ERIA and yield and prioritizing high-potential waste in the ascending cycle path to recover valuable materials to avoid irreversible losses. ERIA provides an additional dimension for waste classification, treatment pathway selection, and therapeutic technology enhancement. Our results are of great significance to foster the governance of the waste disposal industry towards a circular economy and carbon reduction.
Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2
Authors: Lill Roland , Schulz Vinzent , Steinhilper Ralf , Oltmanns Jonathan , Freibert Sven-A. , Krapoth Nils , Linne Uwe , Welsch Sonja , Schünemann Volker , Murphy Bonnie 
Published: November 2023

Abstract
Maturation of iron-sulfur proteins in eukaryotes is initiated in mitochondria by the core iron-sulfur cluster assembly (ISC) complex, consisting of the cysteine desulfurase sub-complex NFS1-ISD11-ACP1, the scaffold protein ISCU2, the electron donor ferredoxin FDX2, and frataxin, a protein dysfunctional in Friedreich’s ataxia. The core ISC complex synthesizes [2Fe 2S] clusters de novo from Fe and a persulfide (SSH) bound at conserved cluster assem-bly site residues. Here, we elucidated the poorly understood Fe-dependent mechanism of persulfide transfer from cysteine desulfurase NFS1 to ISCU2. High-resolution cryo-EM structures obtained from anaerobically prepared samples provided snapshots that both visualized differ-ent stages of persulfide transfer from Cys381NFS1 to Cys138ISCU2 and clarified the molecular role of frataxin in optimally positioning assembly site residues for sulfur transfer. Biochemical analyses assigned ISCU2 residues essential for sulfur transfer, and revealed that Cys138ISCU2 rapidly received the persulfide without a detectable intermediate. Mössbauer spectroscopy assessing the Fe coordination of various sulfur transfer intermediates showed a dynamic equilibrium between pre- and post-sulfur-transfer states shifted by frataxin. Collectively, our study defined crucial mechanistic stages of physiological [2Fe-2S] cluster assembly and clarified frataxin’s molecular role in this fundamental process.
The Effect of Secondary Neuritis on the Optic Nerve in Patients with Chronic Rhinosinusitis
Authors: Moyseyenko Nataliya 
Published: November 2023

Abstract
Background: Chronic rhinosinusitis (CRS) is a common condition that affects millions of people worldwide. Despite its prevalence, the pathophysiology of CRS is not fully understood, and there is a lack of consensus on the definition and diagnosis of this condition.
Methods: 8 patients (16 eyes) aged 18-32 were examined at the Ivano-Frankivsk National Medical University with progressive optic nerve atrophy caused by secondary neuritis combined with sinusitis. We conducted a cross-sectional study of patients with CRS who underwent a comprehensive otolaryngological evaluation, including nasal endoscopy, computed tomography (CT) scan, and allergy testing. Patients were classified into two groups: those with and without secondary neuritis.
Result. Eight patients with optic nerve atrophy caused by secondary neuritis combined with sinusitis examined by OCT. The optic nerve damage in the early period (up to half a year) characterized by the appearance retinal neural fibers layer (RNFL)’s white sectors combined with red-yellow sectors on the side of the lesion. It could be evidence of edematous -degenerative processes.
Later, after more than a year, RNFL’s yellow-red sectors appeared on the side of the lesion and white on the opposite side. The finding characterizes the development of atrophy of the optic nerve and involvement of the opposite side.
Conclusion Our study suggests that secondary neuritis is a common complication of CRS and is associated with more severe symptoms and CT scan abnormalities. Early recognition and treatment of secondary neuritis may help to prevent or slow down the progression of the disease.
Ubiquitous purine sensor modulates diverse signal transduction pathways in bacteria
Authors: Krell Tino , Monteagudo-Cascales Elizabet , Gumerov Vadim , Fernández Matilde , Matilla Miguel , Gavira Jose , Zhulin Igor 
Published: November 2023

Abstract

Purines and their derivatives are key molecules for controlling intracellular energy homeostasis and nucleotide synthesis. In eukaryotes, including humans, purines also act as signaling molecules that mediate extracellular communication and control key cellular processes, such as proliferation, migration, differentiation, and apoptosis. However, the signaling role of purines in bacteria is largely unknown. Here, by combining structural and sequence information, we define a purine-binding motif, which is present in sensor domains of thousands of bacterial receptors that modulate motility, gene expression, metabolism and second messenger turnover. The screening of compound libraries and microcalorimetric titrations of selected sensor domains validated their ability to specifically bind purine derivatives. The physiological relevance of purine sensing was demonstrated in a second messenger signaling system that modulates c-di-GMP levels.
Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens
Authors: Okada Hideho , Kwok Darwin , Stevers Nicholas , Nejo Takahide , Chen Lee , Etxeberria Inaki , Jung Jangham , Okada Kaori , Cove Maggie Colton , Lakshmanachetty Senthilnath , Gallus Marco , Barpanda Abhilash , Hong Chibo , Chan Gary , Wu Samuel , Ramos Emilio , Yamamichi Akane , Liu Jerry , Watchmaker Payal , Ogino Hirokazu , Saijo Atsuro , Du Aidan , Grishanina Nadia , Woo James , Diaz Aaron , Chang Susan , Phillips Joanna , Wiita Arun , Klebanoff Christopher , Costello Joseph 
Published: November 2023

Abstract

T-cell-based immunotherapies hold promise in treating cancer by leveraging the immune system’s recognition of cancer-specific antigens.1 However, their efficacy is often limited in tumors with fewer somatic mutations and significant intratumoral heterogeneity, such as glioblastoma.2–5 Here we introduce a previously uncharacterized class of tumor-wide and public neoantigens, originating from RNA-splicing aberrations in various cancer types. Notably, we identified T-cell receptor clones capable of recognizing and targeting neoantigens derived from aberrant splicing in GNAS and RPL22. In multi-site-directed biopsies across various cancer types, we detected the tumor-wide expression of the GNAS neojunction within glioma, mesothelioma, prostate cancer, and liver cancer patients. Importantly, these neoantigens were proven to be endogenously generated and presented by tumor cells under physiological conditions, which was sufficient in triggering the eradication of cancer cells by neoantigen-specific CD8+ T-cells. Moreover, our study unravels the complex interplay of dysregulated splicing factor expression in specific cancer subtypes, which leads to recurrent patterns of neojunction upregulation. These findings offer a robust molecular basis for T-cell-based immunotherapy that targets a newfound class of tumor-wide public neoantigens, addressing the challenges of intratumoral heterogeneity. By characterizing this unique class of tumor-wide and public neoantigens, our research emphasizes the need to consider intratumoral heterogeneity in the quest for effective cancer immunotherapies. These findings have significant implications for the development of targeted treatments and mark a pivotal step in the ongoing journey to uncover neoantigens for cancer immunotherapy.
Path planning and simulation of Robotic arm based on improved artificial potential field method
Authors: Li YAN , zheng pei , LI Yufei 
Published: November 2023

Abstract
Multi-degree-of-freedom Robotic arm have been widely used in various fields,In this paper, taking the six-degree-of-freedom Robotic arm as the research object.Aiming at the problem that the traditional artificial potential field algorithm is easy to produce the target unreachable during path planning, an improved artificial potential field algorithm is proposed and applied to the path planning of the Robotic arm.The way to improve the algorithm is to add a parameter about the path between the current robotic arm and the target point to the original repulsion function, The original repulsive force is divided into two different directions: one is directed from the obstacle to the Robotic arm, and the other is directed from the Robotic arm to the target point. Due to the instability of the Robotic arm during the path search movement, a three-time quasi-uniform B-spline will be added to smoothly optimize the planned path.
Room temperature experimental implementation of quantum logic on a hybrid magnon-spin system
Authors: Sun Fang-Wen , Jiang Wang , Zang Han-Xiang , Zhang Shao-Chun , Gao Xue-Dong , Yu Cui , Liu Yong , Liu Zhi-Wei , Chen Xiang-Dong , Dong Yang , Guo Guangcan 
Published: November 2023

Abstract
The rapid advancement of quantum information technology has spurred the need for establishing hybrid quantum systems capable of providing complementary functionalities and multitasking
capabilities. Recently, there has been growing interest in hybrid quantum platforms that leverage magnons and other discrete quantum systems. However, the realization of a hybrid quantum system incorporating both a single spin and coherent magnons has remained elusive. In this study, we achieve a significant breakthrough by successfully demonstrating the precise control of a single spin’s state through flexible coherent magnon driving. This accomplishment is made possible through the use of nitrogen-vacancy-center and Yttrium-Iron-Garnet films. Our findings not only underscore the advantages of single spin coherence for implementing high-fidelity quantum logic but also highlight the absence of heat generation of magnon driving resulting from reducing two orders of magnitude energy cost. This, in turn, opens up exciting avenues for further research focused on entangling spin qubits with quantum data bus of magnon within the context of quantum networks.
Estimation of health impacts and morbidity attributed to particulate matter 10 exposure using Air Quality model in Karaj city for 2016–2021
Authors: Sokoty Leily , Qorbani Mostafa , Nami Mohammadian , Shahrestanaki Ehsan , Hassanlouei Babak , Gholami Morteza 
Published: November 2023

Abstract
Background
Determining the impact of air pollution in cities faces two major challenges; First, the limited data on the health effects of pollutants, and second, the lack of information on exposure to air pollutants and their concentrations. Air pollution assessment effects relate to community influence on air pollutants and critical air quality status. The aim of this study was to quantify and estimate the cardiovascular and respiratory diseases caused by PM10 in Karaj in the period 2016–2021.
Methods
In this descriptive-analytical study, after consultation with the Ministry of the Environment, hourly data on PM10 concentrations were initially received from the air pollution station. After the primary and secondary processes and filtering, the data was evaluated with the AirQ2.2.3 software.
Results
The results showed that the mean annual concentration of PM10 during 2016–2021 was 65.39, 5913, 48.45, 46.05, 58.95and 38.30 µg /m3, respectively. The hospitalized number of cases following respiratory disease attributed to PM10 in this period were 853, 774, 627, 588, 293, 551 subjects, respectively, and following cardiovascular disease were 330, 300, 243, 228, 293, 213 subjects, respectively.
Conclusion
The results suggest that health attributed to PM10 decreases in hospital admission rate over time from 2016 to 2021.
A Novel and Efficient Optical Device for Mitigating Methane Emission Risks in Geological and Built-in Environment
Authors: Roy Sandipta , Desikan Ramakrishnan , Duttagupta Siddhartha P. 
Published: November 2023

AbstractMethane, the most deleterious greenhouse gas causes multi-dimensional damage footprint from local to global scales. This necessitates detection of its source and quantifying of its concentration. Widely used compact chemical sensors are sensitive to broad-spectrum of gases, degrade fast and slow in response. Which limits its efficiency in tracing its sources within geological/mine/reclaimed and built-in environments. Contrary, optical sensors are very fast, precisely measures the methane concentration and its flux, and deployable in above mentioned environments. Conventionally, costly InGaAs sensors are used in optical-detectors due to its sensitivity in near Infra-red region (1000–2500 nm). Here, we report development of an efficient spectroscopy-based cost-effective sensor which is methane specific, fast response time and has tremendous application potential in tracking the methane source in above environments. The detector, NiSi Schottky diode, was designed, fabricated, and characterized exclusively for the 1.65 µm, narrow bandwidth methane absorption wavelength. The sensor system, which is of 20 cm length includes a laser source and the NiSi detector. This probe can be easily deployed in boreholes, mine vents and soil layers for measuring real-time fluxes in methane concentrations. From the experiments it is observed that the detection limits of the developed device are very low (3% by volume) and the response time of detection is about 2 seconds. Based on the materials used, fabrication procedures adopted, sensitivity of the device and its compactness, the developed device can be considered as a novel, economic device for effectively measuring and targeting the methane source in above mentioned environment.