bluuebunny/crossref_metadata_2025_split huggingface dataset:
The power of CEO growing up in poverty: Enabling better corporate environmental, social, and governance (ESG) performance
Authors: Liu Yang , Zhang Han , Zhang Fukang 
Published: November 2023

AbstractRecently, environmental, social, and governance (ESG) has been the subject of extensive research and publication. Researchers have pointed out that corporate ESG performance is not only determined by the demographic and personality characteristics of current executives, but also by early‐life experiences. Recent research has illuminated the influence that early‐life experiences of executives have on corporate social performance. However, there is still a lack of research on how executive poverty experiences affects corporate ESG performance. To fill this void, our study investigates the potential influence of CEOs' childhood poverty experiences on corporate ESG performance, employing the upper echelon theory and imprinting theory. Specifically, we gathered data for publicly traded Chinese companies from 2011 to 2020, and discovered that companies helmed by CEOs who grew up in underprivileged neighborhoods demonstrated superior ESG performance. We also scrutinized the moderating mechanisms that impacted the strength and attenuation of poverty imprinting. Our findings reveal that CEO expected tenure and green investors augment the favorable impact of poverty imprinting on corporate ESG performance, while CEOs who receive higher compensation exhibit a weaker imprint. Our study contributes significantly to the imprinting field and the literature on corporate ESG performance, while also providing valuable insights into strategies that facilitate pro‐social conduct among firms.
Smart innovations for sustainable cities: Insights from a public‐private innovation ecosystem
Authors: Cambra‐Fierro Jesús J. , López‐Pérez Mª. Eugenia , Melero‐Polo Iguacel , Pérez Lourdes , Tejada‐Tejada Macarena 
Published: November 2023

AbstractOver‐urbanization poses important challenges—both for citizen well‐being and quality of life, and for the sustainability of our planet. Traffic, accidents and pollution are just a few of the problems facing people living in cities. The need arises, then, to foster sustainable urban planning and management using, among other elements, smart solutions. In such a context, we would do well to reflect on effective economic, social, and environmental policies aimed at achieving sustainable cities and high quality of life for urban inhabitants. This article presents the most relevant aspects of the #eCity‐Sevilla project, a successful case of a sustainable public‐private innovation ecosystem. To this end, we take the Quintuple Helix Model as our reference, with a view to identify project stakeholders and better understand their relationships and objectives. Our data derives from secondary sources as well as from a set of in‐depth interviews with key informants. In the final section, the main theoretical and practical implications of our study are discussed.
Microfluidic characterization of single‐cell biophysical properties and the applications in cancer diagnosis
Authors: Li Shan‐Shan , Xue Chun‐Dong , Li Yong‐Jiang , Chen Xiao‐Ming , Zhao Yan , Qin Kai‐Rong 
Published: November 2023

AbstractSingle‐cell biophysical properties play a crucial role in regulating cellular physiological states and functions, demonstrating significant potential in the fields of life sciences and clinical diagnostics. Therefore, over the last few decades, researchers have developed various detection tools to explore the relationship between the biophysical changes of biological cells and human diseases. With the rapid advancement of modern microfabrication technology, microfluidic devices have quickly emerged as a promising platform for single‐cell analysis offering advantages including high‐throughput, exceptional precision, and ease of manipulation. Consequently, this paper provides an overview of the recent advances in microfluidic analysis and detection systems for single‐cell biophysical properties and their applications in the field of cancer. The working principles and latest research progress of single‐cell biophysical property detection are first analyzed, highlighting the significance of electrical and mechanical properties. The development of data acquisition and processing methods for real‐time, high‐throughput, and practical applications are then discussed. Furthermore, the differences in biophysical properties between tumor and normal cells are outlined, illustrating the potential for utilizing single‐cell biophysical properties for tumor cell identification, classification, and drug response assessment. Lastly, we summarize the limitations of existing microfluidic analysis and detection systems in single‐cell biophysical properties, while also pointing out the prospects and future directions of their applications in cancer diagnosis and treatment.
Predictive modelling of brain disorders with magnetic resonance imaging: A systematic review of modelling practices, transparency, and interpretability in the use of convolutional neural networks
Authors: O'Connell Shane , Cannon Dara M. , Broin Pilib Ó. 
Published: November 2023

AbstractBrain disorders comprise several psychiatric and neurological disorders which can be characterized by impaired cognition, mood alteration, psychosis, depressive episodes, and neurodegeneration. Clinical diagnoses primarily rely on a combination of life history information and questionnaires, with a distinct lack of discriminative biomarkers in use for psychiatric disorders. Symptoms across brain conditions are associated with functional alterations of cognitive and emotional processes, which can correlate with anatomical variation; structural magnetic resonance imaging (MRI) data of the brain are therefore an important focus of research, particularly for predictive modelling. With the advent of large MRI data consortia (such as the Alzheimer's Disease Neuroimaging Initiative) facilitating a greater number of MRI‐based classification studies, convolutional neural networks (CNNs)—deep learning models well suited to image processing tasks—have become increasingly popular for research into brain conditions. This has resulted in a myriad of studies reporting impressive predictive performances, demonstrating the potential clinical value of deep learning systems. However, methodologies can vary widely across studies, making them difficult to compare and/or reproduce, potentially limiting their clinical application. Here, we conduct a qualitative systematic literature review of 55 studies carrying out CNN‐based predictive modelling of brain disorders using MRI data and evaluate them based on three principles—modelling practices, transparency, and interpretability. We propose several recommendations to enhance the potential for the integration of CNNs into clinical care.
Neurodevelopment of children who are HIV‐exposed and uninfected in Kenya
Authors: Bulterys Michelle A. , Njuguna Irene , King'e Maureen , Chebet Daisy , Moraa Hellen , Gomez Laurén , Onyango Alvin , Malavi Kenneth , Nzia Gladys , Chege Martin , Neary Jillian , Wagner Anjuli D. , Lawley Kendall A. , Wamalwa Dalton , Benki‐Nugent Sarah , John‐Stewart Grace 
Published: November 2023

IntroductionPredictors of neurodevelopment among children who are HIV‐exposed uninfected (CHEU) are poorly understood.MethodsMothers with and without HIV and their children were enrolled during 6‐week postnatal care visits across seven sites in Kenya between March 2021 and June 2022. Infant neurodevelopment was assessed using the Malawi Developmental Assessment Tool, including social, language, fine motor and gross motor domains. We used multivariate linear mixed effects models to identify associations between 1‐year neurodevelopment scores, HIV and antiretroviral therapy (ART) exposures, and household factors, adjusted for potential confounders and clustered by the site.ResultsAt 1‐year evaluation, CHEU (n = 709) and children who are HIV‐unexposed uninfected (CHUU) (n = 715) had comparable median age (52 weeks) and sex distribution (49% vs. 52% female). Mothers living with HIV were older (31 vs. 27 years), had lower education (50% vs. 26% primary) and were more likely to be report moderate‐to‐severe food insecurity (26% vs. 9%) (p < 0.01 for all). Compared to CHUU, CHEU had higher language scores (adjusted coeff: 0.23, 95% CI: 0.06, 0.39) and comparable social, fine and gross motor scores. Among all children, preterm birth was associated with lower gross motor scores (adjusted coeff: −1.38, 95% CI: −2.05, −0.71), food insecurity was associated with lower social scores (adjusted coeff: −0.37, 95% CI: −0.73, −0.01) and maternal report of intimate partner violence (IPV) was associated with lower fine motor (adjusted coeff: −0.76, 95% CI: −1.40, −0.13) and gross motor scores (adjusted coeff: −1.07, 95% CI: −1.81, −0.33). Among CHEU, in utero efavirenz (EFV) exposure during pregnancy was associated with lower gross motor scores compared to dolutegravir (DTG) exposure (adjusted coeff: −0.51, 95% CI: −1.01, −0.03). Lower fine and gross motor scores were also associated with having a single or widowed mother (adjusted coeff: −0.45, 95% CI: −0.87, −0.03) or a deceased or absent father (adjusted coeff: −0.81, 95% CI: −1.58, −0.05), respectively.ConclusionsBiologic and social factors were associated with child neurodevelopment. Despite socio‐demographic differences between CHEU and CHUU, 1‐year neurodevelopment was similar. Addressing IPV and food insecurity may provide benefits regardless of maternal HIV status. DTG use was associated with higher neurodevelopmental scores in CHEU, compared to EFV regimens, potentially contributing to a lack of neurodevelopmental difference between CHEU and CHUU.
Aggressive periodontitis in southwestern American Indian adolescents
Authors: Rams Thomas E. , Contreras Adolfo , Slots Jørgen 
Published: November 2023

AbstractBackgroundThis study determined the prevalence of aggressive (molar‐incisor pattern) (Ag/MI) periodontitis and assessed the associated subgingival bacterial‐herpesvirus microbiota in Pueblo Indian adolescents in the southwestern United States.MethodsThe study included 240 Pueblo Indian adolescents, aged 13–20 years old, residing in three Rio Grande River villages in New Mexico and the Hopi Pueblo reservation in Arizona. Adolescents with Ag/MI periodontitis or periodontal health provided subgingival samples for culture of bacterial pathogens and for polymerase chain reaction detection of periodontal herpesviruses.ResultsAg/MI periodontitis was detected in 22 (9.2%) Pueblo Indian adolescents, with 21 exhibiting a localized molar‐incisor breakdown pattern. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and other red/orange complex bacterial pathogens predominated in Ag/MI periodontitis, whereas periodontal health yielded mainly viridans streptococci and Actinomyces species. Periodontal herpesviruses demonstrated a 3.5 odds ratio relationship with Ag/MI periodontitis. The only adolescent with generalized Ag/MI periodontitis harbored viral co‐infection by cytomegalovirus plus Epstein–Barr virus Type 1, in addition to A. actinomycetemcomitans, P. gingivalis, and several other periodontopathic bacteria.ConclusionsPueblo Indian adolescents showed an unusually high prevalence of early‐age Ag/MI periodontitis predominated by periodontopathic bacteria and herpesviruses suspected to be major etiologic agents of the disease.
Decoding Coumaphos: Tracing its journey in the lithosphere via degradation mechanisms and assessing sorption proficiency through kinetics study
Authors: Majid Sara , Ahmad Khuram Shahzad , A. A. Ibrahim , Malik Muhammad Azad 
Published: November 2023

AbstractThe fate of Coumaphos in the environment was evaluated through meticulous emulation and analysis of the intricate pedospheric matrices. The fate‐determinative investigations entailed a meticulous examination of Coumaphos's behavior, encompassing adsorption and desorption characteristics and its decomposition rate via hydrolysis, photolysis, and intrinsic biological degradation in soil. The interactions between Coumaphos molecules and soils were found to be robust, with physiosorption being the predominant mode of interaction. Thermodynamic analysis, based on the negative values of Gibbs free energy (−23,569 to −15,798 kJ/mol), indicated exothermic and spontaneous adsorption processes. The highest adsorption capacity (Kd(ads) = 34.97 μg/mL) was observed in soils with a notable organic matter content (1.99%), exhibiting a C‐type isotherm that was confirmed through linear and Freundlich models. Analytical techniques such as ultraviolet‐visible spectrophotometry and gas chromatography‐mass spectrometry were employed to determine the fate of Coumaphos in soil matrices. The minimum half‐lives of Coumaphos in hydrolysis, biodegradation, and photolysis experiments were 203, 52, and 69 days, respectively. These findings highlight the strong affinity of Coumaphos for the selected agricultural soils, indicating limited potential for transformation. Moreover, findings highlight the potential for further optimization of these degradative routes to devise practical strategies for environmental remediation utilizing natural processes.
When green carbon plants meet synthetic biology
Authors: Wang Qing , Zhang Jianfeng , Dai Qiulan , Cui Meijie , Yang Hao , Cao Peijian , Zhao Lei 
Published: November 2023

AbstractRecycling carbon dioxide (CO2) into chemicals or fuels presents a promising avenue for mitigating carbon emissions and addressing the energy crisis. Plants serve as the ideal platform for the production of materials and chemicals, thanks to their innate capacity to directly use CO2 in the synthesis of various organic compounds. While conventional methods for enhancing plant CO2 fixation may reach their limits, novel technological solutions are imperative. Synthetic biology has illuminated the potential for biosynthesising multiple carbon sources through artificial CO2 fixation pathways in vitro. Recent breakthroughs in photorespiratory bypasses and artificial carboxylation modules offer significant promise for engineering plants to improve carbon fixation, guiding the design and development of plants with more efficient CO2 utilisation. In this context, we begin by summarising recent progress in designing or engineering in vitro CO2 fixation pathways, as well as those solely established in microbes. Subsequently, we delineate strategies employed to enhance CO2 fixation in plants. Finally, we explore potential methods for introducing artificial CO2 fixation pathways into plants. These advancements are critical in advancing synthetic biology's efforts to tackle future challenges related to food and energy scarcity.
Preparation of hydrogen‐bonded supramolecular dual‐network hydrogels with tunable mechanical properties
Authors: Li Huirong , Fang Shaokang , Wang Pengxiang , Feng Shida , Yu Yue , Zhang Hong , Liu Yuanfa , Guo Jing 
Published: November 2023

AbstractHydrogel has a wide range of functionalities and great potential for application in various fields. However, the disadvantages such as weak strength and susceptibility to water loss limit its application in complex environments. In this study, glycerol and water were used as binary solvents to construct dual‐network hydrogels by mixing polyvinyl alcohol (PVA) and the natural polymer gelatin (GEL) through a simple one‐pot method. Glycerol was introduced to form hydrogen bonds with PVA and GEL, on the one hand, resulting in the excellent mechanical properties of the prepared hydrogels; on the other hand, glycerol also endowed the hydrogels with excellent anti‐drying and anti‐freezing properties, which enabled them to be stably applied in extreme environments. In addition, by adjusting the proportion of glycerol, the mechanical properties of the hydrogel can be adjusted to adapt to the applications in different scenarios. This kind of organic hydrogel with adjustable mechanical properties for anti‐drying and anti‐freezing has great potential for development in various fields.Highlights
Organic hydrogels with high mechanical strength were prepared by the one‐pot method.
The anti‐drying and anti‐freezing gel is suitable for extreme conditions.
The multifunctional gel is removable and can be reused to save costs.
Association of inflammation and abnormal lipid metabolism with risk of thrombosis and thrombosis progression in patients with polycythemia vera: a retrospective study
Authors: Lai Hurong , Tu Yansong , Zhang Shan , Liao Caifeng , Tu Huaijun , Li Jian 
Published: November 2023

AbstractTo date, no therapeutic strategy has been shown to be effective in reducing the risk of polycythemia vera (PV) transforming into myelofibrosis or leukemia, and the main goal of current treatment is to prevent thrombotic events. Recent studies have shown that higher levels of inflammation are associated with an increased risk of thrombosis in PV patients, while the correlation between inflammation and abnormal lipid metabolism with the risk of thrombosis in PV has not been reported. In this retrospective study, 148 patients with newly diagnosed PV who visited the Affiliated Hospitals of Nanchang University from January 2013 to June 2023 were categorized into low-risk group and high-risk group according to the risk of thrombosis, and were subsequently divided into thrombosis non-progression group and progression group. The differences of novel inflammatory markers PHR, NHR, MHR, LHR, and SIRI in each group were analyzed and compared with healthy adults who underwent physical examination in the hospitals during the same period. The results showed that PHR, NHR, MHR, and SIRI levels were significantly higher in the PV group than in the control group (P < 0.001), while HDL-C levels were considerably lower (1.09 vs. 1.31, P < 0.001). Comparisons within the groups of PV patients revealed that PHR, MHR, NHR, NLR, and SIRI levels were significantly higher in the high-risk group for thrombosis than in the low-risk group (P < 0.01); the thrombosis PHR, NHR, NLR, and SIRI levels were higher in the group with progression of thrombosis than in the group without progression of thrombosis (P < 0.05), while HDL-C levels were significantly lower (1.02 vs. 1.12, P < 0.001). The results of the ROC curve analysis showed that NHR (AUC = 0.791), HDL-C (AUC = 0.691), PHR (AUC = 0.668), NLR(AUC = 0.658), and SIRI (AUC = 0.638) had high diagnostic efficacy for identifying PV patients with thrombosis progression. Multivariate analysis showed that NHR, NLR, MHR, and LHR were independent risk factors for PV patients with thrombosis progression (P < 0.05). Kaplan–Meier survival curves showed that NHR ≥ 5.82 × 109/mmol, NLR ≥ 6.295, PHR ≥ 280.4 × 109/mmol, MHR ≥ 0.295 × 109/mmol, LHR ≥ 1.41 × 109/mmol, and SIRI ≥ 1.53 × 109/L were risk factors for PFS in PV patients. The study demonstrates for the first time that novel inflammatory markers PHR, NHR, MHR, LHR, and SIRI may be used as new predictors for PV patients with thrombosis progression. NHR has the highest value in predicting thrombosis in PV patients and is superior to NLR which was reported previously.
The impact of anemia and blood transfusion on mortality after open abdominal surgery in the elderly
Authors: Buhl Henrik , Nørgaard Astrid , Otkjaer Astrid , Jørgensen Lars Nannestad , Jørgensen Henrik Løvendahl 
Published: November 2023

Abstract
Background
Major abdominal surgery is associated with considerable mortality in the elderly. Anemia has been linked to increased mortality in other types of surgery, such as hip and cardiac surgery. This study aimed to assess the impact of preoperative anemia on mortality in the elderly undergoing major abdominal surgery, and how allogeneic red cell blood transfusion influences mortality in these patients.

Materials and methods
We conducted a single-center, register-based retrospective study on patients, who were aged beyond 60 years and underwent one of 81 open abdominal surgical procedures. Patients operated on during the period from January 1, 2000, to May 31, 2013, were consecutively identified in the Danish National Patient Registry. Plasma hemoglobin was measured within 30 days prior to surgery and the primary endpoint was 30-day postoperative mortality. Information about patient transfusions from the hospital blood bank was available from 1998 to 2010.

Results
A total of 3199 patients were included of whom 85% underwent emergency surgery. The total mortality after 30 days was 20%. The median preoperative hemoglobin value of survivors was 7.7 mmol/L vs 6.9 mmol/L in those who died. The difference in hemoglobin values, between those who survived or died, decreased from the pre- to the post-operative phase. The 30-day postoperative mortality was 28%, 20%, and 12% in patients with a preoperative hemoglobin level in the lower, median, and upper quartile respectively. Transfusion therapy was associated with higher postoperative mortality, except in patients with very low hemoglobin values.

Conclusion
Preoperative anemia has a clear association with surgically related mortality. The distribution of hemoglobin values in patients with a fatal outcome differs significantly from that of survivors. Red cell transfusion is associated with increased mortality, except in patients with very low hemoglobin values which supports recent guidelines suggesting a restrictive transfusion strategy.
Very low prevalence of haemosporidian parasites in two species of marsh terns
Authors: Dubiec Anna , Atamas Natalia , Ledwoń Mateusz 
Published: November 2023

AbstractVector-transmitted haemosporidians are among the most common parasites in birds, but our knowledge of the inter-specific patterns of infection rates and the parasite community composition is far from complete because of the unequal distribution of the screening effort across bird families and genera. To assess infection rates and the diversity of haemosporidians from the genera Plasmodium, Haemoproteus, and Leucocytozoon in marsh terns, which represent poorly explored in this regard genus of the family gulls, terns, and skimmers (Laridae), we screened two species: the Whiskered Tern (Chlidonias hybrida) and the Black Tern (Chlidonias niger). We sampled these long-distance migratory birds on breeding grounds: the Whiskered Tern in south-central Poland and north-central Ukraine, and the Black Tern—in north-central Ukraine. We found that birds from both species were infected only sporadically, with prevalence at the population level not exceeding 3.4%. Only parasites from the genera Plasmodium and Leucocytozoon were detected. There was neither an inter-specific difference nor a difference between populations of the Whiskered Tern in infection rates. In total, we registered three lineages—one Plasmodium and two Leucocytozoon—that were previously recorded in other bird species, and two unidentified Plasmodium infections. One of the lineages (Leucocytozoon LARCAC02) represents a specialist parasite with the host range restricted to larids and geographic range restricted to Poland, and two others (Plasmodium SGS1 and Leucocytozoon CIAE02) represent generalist parasites with very broad host and geographic ranges. This study reinforces the existing evidence that terns host parasites from genera Haemoproteus, Plasmodium, and Leucocytozoon only sporadically.