bluuebunny/crossref_metadata_2025_split huggingface dataset:
Freshwater conservation: Lost in limnology?
Authors: Barouillet Cécilia , González‐Trujillo Juan David , Geist Juergen , Gíslason Gísli M. , Grossart Hans‐Peter , Irvine Kenneth , Jähnig Sonja C. , Boon Philip J. 
Published: December 2023

Abstract

Although scientific research has identified the causes of undesirable ecological changes in fresh waters, translating the results of research into practical conservation and management, and raising awareness of the need for action, is often inadequate.
This Viewpoint considers the present coverage of conservation‐related freshwater research, the application of science to conservation, the extent of collaboration between international organizations, and the level of awareness of freshwater ecosystems and the need for their conservation.
Far greater attention has been given to conservation in marine than freshwater areas. This is illustrated by the respective number of publications in the scientific literature, an imbalance in the UN Sustainable Development goals, and, until recently, the lack of an explicit reference to freshwater ecosystems in the UN Global Biodiversity Framework.
Four case studies are presented as examples of how freshwater conservation can be made more effective: involving local communities in applying nature‐based solutions; bringing scientists and stakeholders together to discuss how to improve freshwater management; collaborating at a global scale in freshwater protection and restoration; and demonstrating how scientists and government can work together to reconcile the competing needs of nature and human society.
Producing and implementing effective conservation and management plans needs a recognition of the extensive diversity of freshwater habitats and species, as well as a systematic evaluation of how scientific information can be translated into action at local, regional and global scales.
Data on freshwater ecosystems need to be accessible, comprehensible, unambiguous and available to all those working on practical conservation projects. Many international organizations are already active in this field, but greater collaboration would make their work more effective.
Raising awareness needs education and training, carefully targeted at a wide range of audiences, and communicated using the full range of media now available.
Practice, pedagogy and education as a discipline: Getting beyond close‐to‐practice research
Authors: Deng Zongyi 
Published: December 2023

AbstractThe British Educational Research Association (BERA) has promulgated a concept of close‐to‐practice research that is seen as vital to defending and promoting education as an academic discipline. However, what is overlooked are the questions of what education is for and what educational practice is—questions that need to be addressed for any research aiming to understand and improve educational practice. Informed by Robin Alexander's conception of pedagogy, continental Pädagogik and Didaktik and Anglo‐American sources, this paper advances an alternative, different way of thinking about close‐to‐practice research and education as a discipline. It makes a case for education as a distinctive discipline directed towards the understanding and development of practice for the advancement of education. This discipline necessitates an educational and Didaktik way of thinking and theorising, centred on the questions of what education is for, what educational practice is and how practice is supported and developed. This way of thinking and theorising calls for three interrelated lines of research that are significant and matter to practice, particularly within the current context of the National Curriculum in England.
Pharmacokinetics, tissue distribution, and plasma protein binding ratio of bicuculline following intragastric and intravenous administration in rats using ultra‐high‐performance liquid chromatography–tandem mass spectrometry
Authors: Chen Weikang , Zheng Yangbin , Zhu Yanyan , Liu Dehong , Zhu Lianghui 
Published: December 2023

AbstractBicuculline is a natural isoquinoline alkaloid that works as a gamma‐aminobutyric acid receptor antagonist. It is widely found in Papaveraceae plants used in traditional Chinese medicines. Bicuculline not only has been shown to have favorable analgesic, memory‐improving, and anxiolytic effects but may also cause adverse effects such as convulsions and epilepsy. A simple, rapid, and sensitive method was developed and validated for the determination of bicuculline in the plasma and tissue samples in rats by ultra‐high‐performance liquid chromatography–tandem mass spectrometry (MS/MS). The chromatographic separation was performed on a Thermo Scientific C18 column. The MS/MS system was operated in the positive multiple reaction monitoring mode, and the precursor–product ion transitions were optimized as m/z 368.0 → 307.1 for bicuculline and as 354.1 → 188.1 for protopine (internal standard). The linearity, accuracy, precision, recovery, and matrix effect were within acceptable limits. The experimental data showed that bicuculline was rapidly absorbed and eliminated in rats, with a moderate plasma protein binding ratio and low bioavailability. The main tissues of distribution were the kidney, liver, and brain; bicuculline could exert its pharmacological effects across the blood–brain barrier. This study has positive implications for the clinical use of herbal medicines containing bicuculline and for further development.
A bioengineered anti‐VEGF protein with high affinity and high concentration for intravitreal treatment of wet age‐related macular degeneration
Authors: Huang Chengnan , Wang Yuelin , Huang Jinliang , Liu Huiqin , Chen Zhidong , Jiang Yang , Chen Youxin , Qian Feng 
Published: December 2023

AbstractIntravitreal (IVT) injection of anti‐vascular endothelial growth factor (anti‐VEGF) has greatly improved the treatment of many retinal disorders, including wet age‐related macular degeneration (wAMD), which is the third leading cause of blindness. However, frequent injections can be difficult for patients and may lead to various risks such as elevated intraocular pressure, infection, and retinal detachment. To address this issue, researchers have found that IVT injection of anti‐VEGF proteins at their maximally viable concentration and dose can be an effective strategy. However, the intrinsic protein structure can limit the maximum concentration due to stability and solution viscosity. To overcome this challenge, we developed a novel anti‐VEGF protein called nanoFc by fusing anti‐VEGF nanobodies with a crystallizable fragment (Fc). NanoFc has demonstrated high binding affinity to VEGF165 through multivalency and potent bioactivity in various bioassays. Furthermore, nanoFc maintains satisfactory chemical and physical stability at 4°C over 1 month and is easily injectable at concentrations up to 200 mg/mL due to its unique architecture that yields a smaller shape factor. The design of nanoFc offers a bioengineering strategy to ensure both strong anti‐VEGF binding affinity and high protein concentration, with the goal of reducing the frequency of IV injections.
The impact of digital household budgets on online purchase decision‐making processes
Authors: Skwara Florian , Wienert Luca 
Published: December 2023

AbstractRecent literature found positive effects of digital household budget feedback when used over longer timespans. This current study, in turn, investigates whether digital budget feedback also influences consumer behavior in single online purchase decisions. The related research question states: Do transparent technology‐mediated household budgets influence consumers' willingness to pay and payment pain in single, individual online purchase decision processes? The underlying study used a quantitative‐, mixed‐design approach and simulated online purchases for one hedonic and one utilitarian product. Three hundred fourteen study subjects were assigned to either a control group or one of three treatment groups manipulated with specific budget statuses to examine differences in consumer reactions. Critical measures of willingness to pay and payment pain have been taken to analyze potential significant effects. Results found significant differences in consumer willingness to pay and payment pain between and within groups concerning both products. The study could, however, not confirm differences to occur between utilitarian and hedonic purchases. The findings extend existing literature by demonstrating that consumers adjust their online spending based on individual household budget feedback. Consumers that wish to align spending with their current budget status might thus rely on app‐mediated budget updates. At the same time, marketers could offer individualized pricing offers to consumers based on situational budget status information.
Association of autoimmune pancreatitis with Raghib syndrome
Authors: Yousefi Azizollah , Salehi Shima , Radgoodarzi Mohammad , Javid Asma 
Published: December 2023

Key Clinical MessageAutoimmune pancreatitis (AIP) is a form of chronic pancreatitis scarcely found in children. Raghib syndrome is a rare congenital heart defect known as persistent left superior vena cava (LSVC) draining into the left atrium. Total signs of Raghib syndrome in AIP case accompanied by an IgG4‐related disease were described.AbstractAutoimmune pancreatitis (AIP) is a form of chronic pancreatitis scarcely found in children. Raghib syndrome is a rare congenital heart defect known as persistent left superior vena cava (LSVC) draining into the left atrium. Here, we describe Raghib syndrome in AIP case accompanied by an IgG4‐related disease (AIP/IgG4RD). A 13‐year‐old boy presented with a 3‐month history of fever and abdominal pain. The laboratory findings showed SGOT and SGPT, ALP was increased, while amylase and γ‐GT were normal. Immunoglobulins were normal, except for IgG. Endosonography, spiral CT of the abdomen, and cholangiopancreatography showed an enlargement of the pancreas. Contrast echocardiography discovered opacification of the coronary sinus and left atrium. Transesophageal echocardiography for LSVC revealed a dilatation in the coronary sinus, indicating persistent LSVC. Following the injection of agitated saline into the left antecubital vein, bubbles entered both left and right atria in LSVC. It is reasonable to exclude some of these rare disorders as Raghib syndrome, in cases that will be started on medications like corticosteroids, which increases the susceptibility to thromboembolic events.
Getting on the same page in multicultural counseling training
Authors: Kriofske Mainella Alexandra M. , Raval Geeta , Koziol Callie , Callender Karisse 
Published: December 2023

AbstractThis study explored the lived experiences of 21 graduate students in counselor education programs in talking about race, racism, oppression, and privilege in the classroom. We identified four themes from the data that will be shared in the study findings with implications for counselor education, counselor training, and research.
Economic evidence for prevention and treatment of eating disorders: An updated systematic review
Authors: Faller Jan , Perez Joahna Kevin , Mihalopoulos Cathrine , Chatterton Mary Lou , Engel Lidia , Lee Yong Yi , Le Phuong Hong , Le Long Khanh‐Dao 
Published: December 2023

AbstractObjectiveThis systematic review updates an existing review examining the cost‐effectiveness of interventions to prevent and treat eating disorders (EDs).MethodLiterature search was conducted in Academic Search Complete, MEDLINE, CINAHL, PsycINFO, EconLit, Global Health, ERIC, Health Business Elite, and Health Policy Reference Center electronic databases, capturing studies published between March 2017 to April 2023. Hand‐searching was conducted as supplementary including gray literature search. Included articles were (1) full economic evaluations or return‐on‐investment studies, (2) in English and (3) aimed at prevention and treatment of any ED. Included studies were added and synthesized with previously reviewed studies. Screening and extraction followed PRISMA guidelines. Quality assessment was conducted using the Drummond checklist. PROSPERO registration CRD42021287464.ResultsA total of 28 studies were identified, including 15 published after the previous review. There were nine prevention, seven anorexia nervosa (AN) treatment, five bulimia nervosa (BN) treatment, four binge‐eating disorder (BED), and three non‐specific ED treatment studies. Findings indicate value‐for‐money evidence supporting all interventions. Quality assessment showed studies were fair‐to‐good quality.DiscussionThere has been significant growth in cost‐effectiveness studies over the last 5 years. Findings suggest that interventions to prevent and treat ED offer value for money. Interventions such as Featback (ED prevention and non‐specific ED treatment); focal psychodynamic therapy, enhanced cognitive behavioral therapy, and high‐calorie refeeding (AN treatment); stepped‐care with assisted self‐help and internet‐based cognitive behavioral therapy (BN treatment); and cognitive behavioral therapy guided self‐help intervention (BED treatment) have good quality economic evidence. Further research in implementation of interventions is required.Public Significance StatementThe increasing prevalence of ED globally has significant impact on healthcare systems, families, and society. This review is showcasing the value for money of interventions of eating disorders prevention and treatment. This review found that existing interventions offers positive economic benefit for the healthcare system.
Geologically calibrated mammalian tree and its correlation with global events, including the emergence of humans
Authors: Osozawa Soichi 
Published: December 2023

AbstractA robust timetree for Mammalia was constructed using the time calibration function of BEAST v1.10.4 and MEGA 11. The analysis involved the application of times of the most recent common ancestors, including a total of 19 mammalian fossil calibration ages following Benton et al. (Palaeontologia Electronica, 2015, 1–106) for their minimum ages. Additionally, fossil calibration ages for Gorilla, Pan, and a geologic event calibration age for otters were incorporated. Using these calibration ages, I constructed a geologically calibrated tree that estimates the age of the Homo and Pan splitting to be 5.69 Ma. The tree carries several significant implications. First, after the initial rifting at 120 Ma, the Atlantic Ocean expanded by over 500 km around Chron 34 (84 Ma), and vicariant speciation between Afrotheria (Africa) and Xenarthra (South America) appears to have commenced around 70 Ma. Additionally, ordinal level differentiations began immediately following the K–Pg boundary (66.0 Ma), supporting previous hypothesis that mammalian radiation rapidly filled ecological niches left vacant by non‐avian dinosaurs. I constructed a diagram depicting the relationship between base substitution rate and age using an additional function in BEAST v1.10.4. The diagram reveals an exponential increase in the base substitution rate approaching recent times. This increased base substitution rate during the Neogene period may have contributed to the expansion of biodiversity, including the extensive adaptive radiation that led to the evolution of Homo sapiens. One significant driving factor behind this radiation could be attributed to the emergence and proliferation of C4 grasses since 20 Ma. These grasses have played a role in increasing carbon fixation, reducing atmospheric CO2 concentration, inducing global cooling, and initiating Quaternary glacial–interglacial cycles, thereby causing significant climatic changes.
Habitat turnover in Iberian and Italian lizards: Is it climatically, spatially, or phylogenetically determined?
Authors: Escoriza Daniel , Pascual Guillem , Mestre Laia 
Published: December 2023

AbstractThe Mediterranean peninsulas host rich assemblages of lizards, but little is known about the factors that limit their habitat use on large spatial scales. In this study, we investigated the variation in habitat use of 29 species of lacertid lizards on the Iberian and Italian peninsulas and the transitional region of southeastern France. We investigated whether the types of habitat used were phylogenetically determined or, in contrast, were more influenced by spatial or climatic effects. We characterized the vegetal composition of 483 habitats used by lacertids and estimated the contribution of each component to habitat variability using distance‐based redundancy analysis. We showed that overall turnover patterns were determined similarly in both peninsulas, despite differences in the composition of the lacertid assemblages. The aridity‐related component dominated over the phylogenetic one, which has a weak influence in both regions. The species showed different turnover patterns, being low in those present in cold alpine habitats and shrub‐steppe specialists. In some Iberian endemics, habitat turnover occurs within relatively homogeneous climatic bands. However, in the Italian species, habitat turnover has a comparatively stronger climatic component, suggesting lower climatic specialization. This study shows that species distributions across habitats provide information to assess community properties and can be applied to explore differences among faunal assemblages over large geographic areas. Our results provide evidence that beta diversity can play a key role in structuring patterns of habitat turnover.
Concise Synthesis of Thiazolo[4,5‐b]indoles via Ring Switch/Cyclization Sequences
Authors: Yamada Koji , Tsubogo Tetsu , Kanazawa Hikaru , Ishizuka Sayaka , Ohyama Koutaro , Kaida Masaki , Abe Takumi 
Published: December 2023

AbstractThe unexpected reactions of indoline hemiaminals affords 2,5‐diaryl‐4‐hydroxythiazolines through a thioamidation/ring switch sequence. The key to success of this transformation is to use a thioamide as a thiazoline precursor under transient tautomeric control. This transformation features mild reaction conditions and good yields with broad functional group tolerance (17 examples, up to 99 % yield). Further transformations of the thiazolines provide a direct entry to dihydrothiazolo[4,5‐b]indoles and thiazolo[4,5‐b]indoles.
Hydromorphological response of heavily modified rivers to flood releases from reservoirs: A case study of the Spöl River, Switzerland
Authors: Hashemi Saman , Carrivick Jonathan , Klaar Megan 
Published: December 2023

AbstractReleasing experimental floods as part of environmental flow programs aims to restore river beds by moving and restoring sediments to improve hydromorphological conditions of the river. However, it remains a challenge to understand how flood release characteristics affect channel morphology, sediment transport, and hydrodynamics. In this study, field surveys and a 2D hydro‐morphodynamic and sediment transport numerical model were used to determine how differences in flood magnitude and falling limb alter hydrogeomorphic conditions within a 4 km reach of the lower Spöl River. The model was constrained by drone flight‐derived high‐resolution digital elevation models and two field‐measured flood releases. The highest flood magnitude of 40 m3/s resulted in 2,700 m3 of total sediment transport, 2,000 m3 of net total volumetric change and 16 900 m2 more wetted area after the flood. The same flood, simulated with an increase in falling limb slope, resulted in a decrease in the duration of full sediment mobility and a corresponding reduction of 8% in net total volumetric change and 5.3% in the total wetted area. Contrastingly, the lowest flood magnitude of 25 m3/s produced 130% lower total sediment transport, 105% lower net total volumetric changes and 10% less wetted area after the flood. Overall, we show that hydro‐morphodynamic modelling of river erosion and deposition combined with spatially rich topographic datasets are extremely useful in forming designed environmental flood scenarios to optimise sediment transport and thus hydrogeomorphic changes to set environmental flows. We contend that scenario modelling is necessary to help water managers optimise the amount of water allocated to environmental flows and to simultaneously restore and maintain riverine dynamics in heavily modified rivers.
Sand, hearths, lithics and a bit of bioturbation: Site formation processes at Umhlatuzana rockshelter, South Africa
Authors: Sifogeorgaki Irini , Huisman Hans , Karkanas Panagiotis , Schmid Viola C. , Dusseldorp Gerrit L. 
Published: December 2023

AbstractUmhlatuzana rockshelter is known for its continuous record of Middle and Later Stone Age lithic assemblages. This study presents multiproxy geoarchaeological data (micromorphology, X‐ray diffraction and scanning electron microscopy with energy‐dispersive spectroscopy) to reconstruct the depositional and post‐depositional history of the site. Although the Stone Age deposits macroscopically appear homogeneous, micromorphological analysis reveals the existence of primary, unaltered depositional microlayering throughout the sequence. Sediments related to combustion activities on‐site are observed in both the Holocene and Pleistocene deposits. Post‐depositional geochemical alterations result in the formation of several phosphatic minerals that significantly affect the site's preservation conditions. One of those is vashegyite, a rare magnesium phosphate mineral related to acidic and moist sedimentary environments. Bioturbation features are prominent at the microscale, but sediment mixing does not seem to affect the vertical distribution of the artifacts. The observation of horizontal microlayering in both the Pleistocene and Holocene illuminates the dominant mechanism of sedimentation throughout the site's 70,000‐year occupational history. It moreover shows that the lithics can be analysed as coherent assemblages.
Effect of compression ratio and injection timing on the performance of microalgae‐based biodiesel blend
Authors: Galande Swapnil , Pangavhane D. R. , Campli Srinidhi 
Published: December 2023

AbstractThe manuscript addressed experimental work related to microalgae‐based biodiesel blend B20, that is, 20% algae biodiesel and 80% diesel, as an alternative fuel as a possible source to power diesel engines. The physiochemical characteristics of this B20 blend were almost in line with diesel fuel as per American Society for Testing and Material standards. Coupled experimentation related to variations in compression ratio (CR) 17, 19, and 21 and fuel injection timing (IT) of 21°, 23°, and 25° before top dead center (bTDC) with load variations noted on diesel engines. We observed that, at full load, CR21 and 23° bTDC fuel IT, the brake thermal efficiency parameters rose significantly, whereas brake‐specific fuel consumption, and combusted flue gas temperatures also plummeted. The CO, HC, and smoke opacity emission for the B20 blend at CR21 and FIT23 has decreased by 30.52%, 33.33%, and 32.96%, respectively. At full load conditions, NOx emission for B20 biodiesel at CR21 was increased compared with the standard setting and compared with diesel it was increased by 6.46%.
DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers
Authors: Zhu Yitong , Li Wenbin , Lan Fei , Chen Siting , Chen Xiaofei , Zhang Xiaohe , Yan Xiaohui , Zhang Ye 
Published: December 2023

AbstractMonitoring tumor biomarkers in a non‐invasive manner for tumor diagnosis has attracted increasing attention. Liquid biopsy mainly includes three types of biomarkers: circulating tumor cells, extracellular vesicles, and circulating nucleic acids. These biomarkers released by tumor cells can travel to other parts of the circulation system. The analysis of circulating tumor markers in the circulation enables early tumor diagnosis, progression evolution, and treatment monitoring, which are important for individualized clinical decisions. In this study, we summarize different DNA nanotechnology strategies that can be used to capture, amplify, and measure circulating biomarkers and discuss the current challenges and outlook.