bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-perceived impact of COVID-19 measures and adolescent mental health: gender, age and socioeconomic differences in 22 Countries
Authors: Reiss Franziska , Cosma Alina , Bersia Michela , Erhart Michael , Dalmasso Paola , Devine Janine , Hulbert Sabina , Catunda Carolina , Gobina Inese , Giladi Ariela , Klanšček Helena Jeriček , Sieberer Ulrike Ravens 
Published: February 2024

Abstract

Background
The COVID-19-pandemic had a profound impact on the adolescents’ lives worldwide. In our study, we examined the self-perceived impact of the COVID-19 pandemic measures and its association with mental health and well-being among a representative sample of 13-and 15-years-old adolescents from 22 countries.
Methods
Data from the cross-national Health Behaviour in School-aged Children (HBSC) 2021/22 study was used (N = 67,544; 51.9% girls). Self-perceived impact of COVID-19 measures was assessed by 10 items asking about its impact on e.g., relationships with family and friends, health, or eating behaviours. Mental health was evaluated by loneliness, psychosomatic health complaints, and life satisfaction. First, a non-parametric multilevel latent class analysis considering individual, and country-levels was conducted to identify COVID-19 impact groups. Second, logistic regression models adjusted by age and socioeconomic status were applied in order to assess the association between COVID-19 impact classes and mental health. The regression analyses were stratified by gender.
Results
Three classes were identified on individual level encompassing a neutral (51%), negative (18%) or positive (31%) perception of COVID-19 impact. No heterogeneous results of distribution were found within and across countries. Within the positive impact class, social relationships were the most important dimension, whereas mental health problems were mostly represented within the negative impact class. Adolescents with a negative perception of the COVID-19 showed worse mental health than peers with a neutral or positive perception. Girls with a negative perception showed higher levels of loneliness and psychosomatic health complaints and lower life satisfaction compared to boys and peers with a neutral or positive perception. Older adolescents and those with a low socioeconomic status showed more loneliness and lower life satisfaction.
Conclusions
The impact of COVID-19 pandemic showed quite heterogeneous patterns both within and across countries. Support interventions and health promotion should focus especially on girls, older adolescents, and those with a low SES as they were at higher risk of suffering from pandemic measures and associated problems of loneliness, psychosomatic complaints, and low life satisfaction. Adolescents are able to reflect on measures that impact their health and therefore should be involved in the decision-making process.
Temporal Trends in the Prevalence of Hypertensive Heart Disease in Women of Childbearing Age Over 30 Years
Authors: Hu Ben , Wang Yan , Chen Dong , Feng Jun , Fan Yinguang , Hou Linlin 
Published: February 2024

Abstract

Aim
Epidemiological research on hypertensive heart disease (HHD) in women of childbearing age (WCBA) remains scarce. Our objective is to describe the current prevalence of HHD in WCBA at global, regional, and national levels and to analyze its temporal trends from 1990 to 2019.
Methods
WCBA was defined as women aged 15–49 years. Estimates and 95% Uncertainty Intervals (UI) of HHD prevalence numbers for seven age groups (15–19, 20–24, 25–29, 30–34, 35–39, 40–44, 45–49 years) were extracted from the 2019 Global Burden of Disease Study (GBD). The age-standardized prevalence rate (ASPR) of HHD in WCBA was estimated using the direct age-standardization method. Joinpoint regression analysis was used to calculate the Annual Percentage Change (APC) and Average APC (AAPC) along with their 95% Confidence Intervals (CI), analyzing the temporal trends from 1990 to 2019.
Results
In 1990 and 2019, the global ASPR of HHD in WCBA was 23.20 (95% UI: 12.72 to 38.43) and 23.67 (95% UI: 13.02 to 38.73), respectively, with high Socio-Demographic Index (SDI) regions generally exhibiting higher ASPRs than other regions. From 1990 to 2019, there was a significant global increase in HHD WCBA (AAPC = 0.08%, 95% CI:0.03 to 0.12; P < 0.001), with notable increases in high-middle SDI region (AAPC = 0.78%, 95%CI: 0.69 to 0.88; P < 0.001), middle SDI region (AAPC = 0.32%, 95%CI: 0.27 to 0.37; P < 0.001), low-middle SDI region (AAPC = 0.50%, 95%CI: 0.44 to 0.56; P < 0.001), and low SDI region (AAPC = 0.36%, 95%CI: 0.34 to 0.37; P < 0.001). However, HHD in high SDI regions significantly decreased (AAPC = -0.52%, 95% CI: -0.74 to -0.31; P < 0.001). The most significant changes occurred in different periods. The ASPR trends of HHD in WCBA varied greatly among 204 countries and territories.
Conclusions
Between 1990 and 2019, there was strong heterogeneity in the ASPR of HHD in WCBA globally and in its temporal trends (1990–2019). The ASPR decreased in high SDI regions but continuously increased in low SDI regions. These findings highlight the stark global disparities in HHD among WCBA, with significant implications for the equitable allocation of medical resources and the formulation of relevant health policies.
Biological activity and structure-activity relationship of functionalized thiols against Leishmania major, the agent of human cutaneous leishmaniasis
Authors: Dondji Blaise , Henne Taylor , Curry Linsey , Smith Cameron , Gunther Kenlei , Braunstein Hannah , Farah Abdikani Omar , Beng Timothy 
Published: February 2024

Abstract
Leishmania are protozoan parasites causing a spectrum of pathologies in humans grouped under the name leishmaniasis. Clinical outcomes range from the self-healing cutaneous form to the visceral one that is fatal in the absence of treatment. The leishmaniases are endemic in 98 countries in the tropics, subtropics, and southern Europe where 3 million new cases and more than 50,000 deaths are recorded yearly. The control of the disease is challenging with no approved vaccine coupled with toxic chemotherapeutics and development of parasite resistance to some available drugs. It is therefore evident that identification of new control methods including new therapeutics should be strongly encouraged. In the present study, thiol organic compounds were synthesized and tested for their activity against Leishmania major, the causative agent of human cutaneous leishmaniasis. Of the 21 compounds tested, 13 were active against L. major promastigotes in vitro at 100 µg/mL. Selected compounds tested in a dose-response assay showed activity at concentration as low as 25 µg/mL, a level of activity similar to that of Amphotericin B, a drug of choice for the treatment of human leishmaniasis. Structure-activity analysis shows that the addition of certain substituents such as a methoxy group to a compound that was biologically active renders it inactive. Together, our data demonstrate that functionalized thiols have in vivo anti-Leishmania activity that is directly linked to their chemical structure.
PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in Non-small cell lung cancer
Authors: Lu Jun , Peng Lu , Zhao Yujiao , Tan Jiang , Hou Jingyao , Jin Xin , Liu Dong-Xu , Huang Baiqu 
Published: February 2024

Abstract

Abnormal epigenetic modifications are involved in the regulation of Warburg effect in tumor cells. Protein arginine methyltransferases (PRMTs) mediate arginine methylation and have critical functions in cellular responses. PRMTs are deregulated in a variety of cancers, but their precise roles in Warburg effect in cancer is largely unknown. Experiments from the current study showed that PRMT1 was highly expressed under conditions of glucose sufficiency. PRMT1 induced an increase in the PKM2/PKM1 ratio through upregulation of PTBP1, in turn, promoting aerobic glycolysis in non-small cell lung cancer (NSCLC). The PRMT1 level in p53-deficient and p53-mutated NSCLC remained relatively unchanged while the expression was reduced in p53 wild-type NSCLC under conditions of glucose insufficiency. Notably, p53 activation under glucose-deficient conditions could suppress USP7 and further accelerate the polyubiquitin-dependent degradation of PRMT1. Melatonin, a hormone that inhibits glucose intake, markedly suppressed cell proliferation of p53 wild-type NSCLC, while a combination of melatonin and the USP7 inhibitor P5091 enhanced the anticancer activity in p53-deficient NSCLC. Our collective findings support a role of PRMT1 in the regulation of Warburg effect in NSCLC. Moreover, combination treatment with melatonin and the USP7 inhibitor showed good efficacy, providing a rationale for the development of PRMT1-based therapy to improve p53-deficient NSCLC outcomes.
VolcanoSV enables accurate and robust structural variant calling in diploid genomes from single-molecule long read sequencing
Authors: Zhou Xin , Luo Can , Liu Yichen 
Published: February 2024

Abstract

Structural variants (SVs) significantly contribute to human genome diversity and play a crucial role in precision medicine. Although advancements in single-molecule long-read sequencing offer a groundbreaking resource for SV detection, identifying SV breakpoints and sequences accurately and robustly remains challenging. We introduce VolcanoSV, an innovative hybrid SV detection pipeline that utilizes both a reference genome and local de novo assembly to generate a phased diploid assembly. VolcanoSV uses phased SNPs and unique k-mer similarity analysis, enabling precise haplotype-resolved SV discovery. VolcanoSV is adept at constructing comprehensive genetic maps, encompassing SNPs, small indels, and all types of SVs, making it well-suited for human genomics studies. Our extensive experiments demonstrate that VolcanoSV surpasses state-of-the-art assembly-based tools in the detection of insertion and deletion SVs, exhibiting superior recall, precision, F1 scores, and genotype accuracy across a diverse range of datasets, including low-coverage (10x) datasets. Additionally, VolcanoSV outperforms assembly-based tools in the identification of complex SVs, including translocations, duplications, and inversions, in both simulated and real cancer data. In comparison to existing alignment-based tools, VolcanoSV is robust to evaluation parameters and accurately identifies breakpoints and SV sequences.
Experimental Investigation of H-beam to Recycled Aggregate Concrete Column Edge Connections under Cyclic Loading
Authors: yang qinpeng , Liu Jian 
Published: February 2024

Abstract

This paper aims to investigate the cyclic performance of the connections between the recycled aggregate concrete (RAC) column and steel H-beam. In this connection system, the steel beam is welded to the end plate to form an integral unit, which is bolted to the column. The differences in seismic performance between the novel casing-type one-side bolted end-plate connection and the conventional all-welded joint with external diaphragm and top-seat angle connection were investigated. Three types of joints with different connection details were designed and fabricated at a reduced scale of 1:2, following the principle of strong columns and weak beams. The low cyclic lateral loading test was performed by beam-end loading to observe the loading process and failure morphology of the joint model. The load-beam end displacement hysteresis curve and the skeleton curve were obtained to analyze the joint load eigenvalues, ductility, energy dissipation, and stiffness degradation. The experimental results showed that all three specimens exhibited beam-end failure and demonstrated good ductility. Furthermore, a finite element model was established. The effects of axial compression ratio, steel tube width-to-thickness ratio, outer tube, and end-plate thickness on the bearing performance of the outer tube one-side bolted end-plate joint under lateral loading were analyzed. It was found that the bearing capacity and stiffness of the specimens increased with increasing steel tube width-to-thickness ratio, outer tube thickness, and end-plate thickness. Changes in the axial compression ratio had little effect on the bearing capacity and stiffness of the specimens.
Unsatisfactory screening rates for Primary Aldosteronism in high risk patients
Authors: Korman Avital Angel , Rapoport Vladimir , German Hadassa Seged , Niddam Naomi Nakash , Katzir Zeev , Hausmann Michael , Leiba Adi 
Published: February 2024

Abstract
The Endocrine Society (ES) guidelines recommend screening for primary aldosteronism (PA) in high risk hypertensive patients presenting with at least one of seven criteria (resistant HTN, hypokalemia, adrenal nodule etc.).
Although guidelines are clear and screening is simple, compliance rates among clinicians are extremely low. This results in underdiagnosis of early disease, leading to cadiovasculaer complications and extra-burden of advanced chronic kidney disease.
We aimed to evaluate the screening rates in the Nephrology and Hypertension clinics at Assuta Ashdod University Hospital, Israel.
Data on adult hypertensive patients was retrieved during January 2018 to December 2020. Included in the study were hypertensive patients who had at least one of the ES criteria for PA screening. Of all suitable patients, we compared those who were screened for PA to patients who were not screened. Univariate and multivariate cox regression analysis were used for comparison between groups.
Of 661 patients with HTN, 218 patients (33%) met the ES guidelines for PA screening. Forty-six of them (21.1%), were referred for screening. Advanced age and male gender were associated with lower screening referral rates. Odds ratio for age was 0.945 for every year (95% CI 0.915-0.975). There was a trend towards decreased referral rate in advanced kidney disease.
A 21% screening rate, suggests that many cases of PA are likely missed, more often in older patients.We therefore advocate for PA screening of all hypertensive patients, especially elderly patients with CKD, in whom clinicians’ awareness is low but the absolute risk is high.
The difference in patient-centered medical experiences between public fertility care and private fertility care in China: A multicenter cross-sectional study
Authors: Liang Jiangying , Jie Qiuling , Xu Wen , Li Juan , Fu Mianai , Liu Ping , Chen Yan , Wang Xiaoman , Li Xianmei , Li Zhaoping , Wang Mingkun , Kang Jinyu , Sun Fei , Li Qi , Ma Yanlin , Li Juan 
Published: February 2024

Abstract

Background High-quality fertility care should be effective and safe but also patient-centered. We aimed to analyze the difference in the patient-centered medical experiences between public and private fertility care in China. Methods A multicenter cross sectional study was distributed among 1900 infertile Chinese patients from July 2021 to April 2022. In this study, 1900 infertility patients completed the survey at ten reproductive medicine centres. Patients' experiences of infertility patients were analyzed. Univariate analysis and multivariate regression model analysis were used to analysis the factors influencing the differences in patients' medical experiences between public and private fertility care. Results The questionnaire was completed by 1694 infertile couples (net response rate of 86%) from 10 centres. Of the eight subscales, 'care organization' received the best ratings, and 'information' received the worst ratings. The total score of private fertility care was significantly higher than that of public fertility care. The subscale scores for 'accessibility', 'information' and 'continuity and transition' were significantly higher for private fertility care than for public fertility care. Further univariate and multivariate analyses found that the distance from the hospital, family income and pregnancy status were the main influencing factors of the patients' medical experiences with public fertility care, while the stage of fertility treatment, infertility duration and pregnancy status were the main influencing factors of the patients' medical experiences with private fertility care. Conclusions The subscale of patient-centered medical experiences for 'accessibility', 'information' and 'continuity and transition' were significantly higher for private fertility care than for public fertility care.
Evidence of Increased Lake Heatwave Indices in a Subtropical Coastal Shallow Lake Estimated From Climate Change Scenarios
Authors: Ferrari Carlos Henrique Saldanha , Bravo Juan Martín , Marques David da Motta , Rodrigues Lúcia Helena Ribeiro 
Published: February 2024

Abstract

Water temperature is a driver of chemical, physical, and biological processes in lake systems. Given that these ecosystems are vulnerable to extreme temperature events, it is crucial to assess the potential impacts of climate change scenarios on the structure and functioning of lake systems. Within this context, this study used the concept of lake heatwaves to assess these impacts in Lake Mangueira, a subtropical coastal shallow lake located in the extreme south of Brazil. The Air2Water model was calibrated and used to estimate daily time-series water temperatures using daily time-series air temperatures as the input. The occurrence of lake heatwaves in Lake Mangueira was assessed over a historical period (1985–2014) and according to three future (2081–2100) scenarios — SSP1-2.6, SSP2-4.5, and SSP5-8.5 — based on data from 26 global climate models (GCMs). The results were expressed in terms of heatwave indices, which were initially proposed for marine environments and have since been applied to lake ecosystems. Most of the projections obtained indicated positive anomalies for all lake heatwave indices, especially for the average duration and cumulative intensity and in the SSP5-8.5 scenario, compared to the historical period. In addition to the total duration, two of the five indices evaluated were presented for each year associated with the historical period and future scenarios. This analysis revealed an increase in the mean values of these indices in the three future scenarios compared to the historical period, again with SSP5-8.5 standing out. Finally, lake heatwaves lasting more than one season were projected for Lake Mangueira, with some projections indicating the permanent occurrence of these extreme events. Properly studying these events is of paramount importance in the management of lake systems and their associated environmental services.

Keywords: lake ecosystems, water temperature, modeling, remote sensing, extreme events, climate change.
Fear and Challenging behavior: A Phenomenological-Hermeneutic Study of people with public mass shooting attacks during the COVID-19 pandemic in Thailand
Authors: Imkome Ek-uma 
Published: February 2024

Abstract

Background Public mass shooting attacks during the COVID-19 pandemic have had a significant impact on victims. Understanding and realizing the biological, psychological, and social impact of the problem and the individual's needs may help the nurse design the nursing intervention to meet the individual needs of the victims, which can reduce mortality and disability rates.
Aim This phenomenological-hermeneutic study aims to describe and interpret the perspectives of people with public mass shooting attacks during the COVID-19 pandemic.
Methods Data were collected in dialogical conversations with 15 people who were involved in a mass shooting during the COVID-19 attack using a random sampling method: purposive sampling and snowball techniques. Analyze by using thematic analysis. The COREQ guidelines for reporting qualitative studies were performed.
Results A group of people who have been involved in a mass shooting during the COVID-19 outbreak revealed five main themes, which are fear, being in the same boat, impact, coping, and intervention.
Conclusion The fear and challenge behavior will have implications for health care providers, including prioritizing validating interactions and adopting a relational approach to practice.
In search of meaning in loss; Clarification of adaptation strategies of the elderly in the face of the death of a spouse: A qualitative study
Authors: Seraji Asal , Nasrabadi Tahereh , Nayeri Nahid Dehghan , Nasrollah Sepideh 
Published: February 2024

Abstract

The death of a spouse is one of the most profound and devastating events in life for the elderly, which can cause serious problems, especially in people who are not in perfect health, and disrupt their coping capacity, thus making their ability to maintain a healthy lifestyle a great challenge that only a small number of them can adapt to. Failure to use the appropriate strategies to adapt to this process can put an elderly person at greater risk of illness or even death. Since the strategies of the elderly in facing the context-based bereavement phenomenon are different from other people, the purpose of this study is to explain the strategies of the elderly in coping with the death of their spouse. Method This qualitative study was conducted with the content analysis approach. 21 elderly participants, who experienced the death of their spouse, were selected purposefully. This qualitative study was conducted with a content analysis approach. Twenty-one elderly participants with experience of spouse death were purposefully selected. Data were collected using semi-structured interviews until saturation was reached. Data were analyzed based onLundmanandGranheim'scontent analysis approach. Findings By analyzing the data, information was explained in two main categories: 1- Mental engagement with the deceased, including six subcategories (constant thinking about the deceased, similarity finding, reminiscence, paying attention to the symbols of remembrance, recalling the efforts and rumination) 2- Recovery of the bond with the deceased, including six sub-categories (participation in the burial, dealing with rituals, holding a memorial, phantom spouse, engaging in the activities of interest of the deceased and preoccupation with the belongings of the deceased). Conclusion Contrary to the written assumption, the Mental engagement with the deceased acts like a double-edged sword, depending on the intensity and duration, and sometimes not only is not destructive and harmful but also helps distract the survivor, thus creating an opportunity to accept the loss. For example some subcategories of the Mental engagement with the deceased among categorized strategies, like constant thinking or rumination with the deceased some of these subclasses like constant thinking of the deceased or rumination, which act in this way, regardless of being different in terms of semantic connotation. In such a way that for example, rumination which is in contrast to adaptation, is not necessarily negative and prohibiting. In recovery of the bond with the deceased category, similarity finding, and phantom Spouse to maintain a new and symbolic relationship with the deceased, among others, are novel strategies that are completely unconsciously utilized by most of the elderly, which are suggested to be considered for their positive effects.