bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can the Clinical Utility of iBreastExam, a Novel Device, Aid in Optimizing Breast Cancer Diagnosis? A Systematic Review
Authors: Bhimani Fardeen , Zhang Janice , Shah Lamisha , McEvoy Maureen , Gupta Anjuli , Pastoriza Jessica , Shihabi Areej , Feldman Sheldon 
Published: November 2023

PURPOSE A portable, cost-effective, easy-to-use, hand-held Intelligent Breast Exam (iBE), which is a wireless, radiation-free device, may be a valuable screening tool in resource-limited settings. While multiple studies evaluating the use of iBE have been conducted worldwide, there are no cumulative studies evaluating the iBE's performance. Therefore this review aims to determine the clinical utility and applicability of iBE compared with clinical breast examinations, ultrasound, and mammography and discuss its strengths and weaknesses when performing breast-cancer screening. METHODS A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Four electronic databases were searched: PubMed, Cochrane Library, Web of Science, and Google Scholar. RESULTS The review included 11 studies with a total sample size of 16,052 breasts. The mean age ranged from 42 to 58 years. The sensitivity and specificity of the iBE ranged from 34.3% to 86% and 59% to 94%, respectively. For malignant lesions, iBE demonstrated a moderate to higher diagnostic capacity ranging from 57% to 93% and could identify tumor sizes spanning from 0.5 cm to 9 cm. CONCLUSION Our findings underscore the potential clinical utility and applicability of iBE as a prescreening and triaging tool, which may aid in reducing the burden of patients undergoing diagnostic imaging in lower- and middle-income countries. Furthermore, iBE has shown to diagnose cancers as small as 0.5 cm, which can be a boon in early detection and reduce mortality rates. However, the encouraging results of this systematic review should be interpreted with caution because of the device’s low sensitivity and high false-positive rates.
Association of Pancreatic Adenocarcinoma Location With DNA Damage Response Status and Response to Platinum-Based Therapy
Authors: Micaily Ida , Blais Edik M. , Carhart Randi , Lam Sophia , Cohen Steven J. , Cannaday Shawna J. , Halverson David , Matrisian Lynn M. , DeArbeloa Patricia , Thach Dzung , Petricoin Emanuel , Pishvaian Michael J. , Lavu Harish , Yeo Charles J. , Mallick Atrayee Basu 
Published: November 2023

PURPOSE Pancreatic adenocarcinoma is an aggressive disease with poor clinical outcomes. Primary pancreatic tumors originating from the head of the pancreas (H) have different prognostic implications than tumors arising from the body and tail (BT). This is thought to be largely due to anatomic differences, as molecular underpinnings of survival have not been fully explored. We hypothesized that differences in the primary site of H and BT tumors might account for differential molecular outcomes and response to chemotherapy. METHODS Retrospective data from a single high-volume academic center were analyzed for hypothesis generation. A large-scale, real-world retrospective cohort of 2015 patients with next-generation sequencing (NGS) results were analyzed from a Real-World Evidence database. Progression-free survival (PFS) was evaluated from the initiation of first line of therapy for advanced disease until discontinuation because of progression. HR and P values were computed via Cox regression between first-line FOLFIRINOX and gemcitabine/nanoparticle albumin-bound (gem/nab) paclitaxel. Differences in frequencies of genomic alterations between H and BT were analyzed by Fisher's exact test. RESULTS Genomic alterations in the DNA damage response (DDR) pathway (such as BRCA1, BRCA2, and PALB2) were enriched (unadjusted P value = .00244) in BT tumors (21.7% of 618) relative to H tumors (15.6% of 942) where BRCA2 was a top contributor within this pathway. Median PFS in BT tumors on first-line FOLFIRINOX was longer than first line gem/nab-paclitaxel ( P = .006393); this difference was not identified in H tumors ( P = .5546). CONCLUSION DDR pathway alterations including BRCA1/ BRCA2/ PALB2 are known predictors of increased benefit from platinum-based chemotherapy. NGS testing for germline and somatic mutations remains important in pancreatic ductal adenocarcinoma, especially in BT tumors where DDR pathway alterations may be more common than in H tumors.
Making Sustainability Concrete
Authors: Sims Christo , Sivakumar Akshita 
Published: November 2023

Abstract
“Sustainability” is an increasingly fashionable design criterion for celebrity corporate architects, their clients, and the governmental bodies that regulate urban development. Yet determining if and how a building is actually sustainable remains controversial, with different actors positing qualifications that are often at odds with each other. In this article, the authors explore how the ideal of sustainability is made concrete in contemporary corporate architecture, focusing on the design of one of Google's new corporate campuses in Silicon Valley that has been extensively touted and recognized as admirably green. The article draws attention to how various experts who participated in the design of Google's new campus rendered sustainability differently and argues that the temporal and social structure of the design process worked to compel coordination and compromises among these experts’ different renderings. Ultimately the authors advocate for problematizing the design process as a key site where political questions about sustainability in the built form get settled pragmatically.
Remote communities, material entanglements and information and communications technologies as double agents
Authors: Horn Christine 
Published: November 2023

Digital devices and Information and Communications Technology or ICT play a prominent role in most people’s everyday lives, as the often unconscious, mostly unacknowledged entanglements between people, devices and infrastructure shape contemporary lives and co-determine activities and their outcomes. Communications technologies are particularly agentic for people who live in rural and remote parts of the world because they often lack easy access to goods and services that are ubiquitous in more urbanized areas. At the same time, access to ICTs in these areas is often tenuous because the maintenance of ICT infrastructure is not always economically viable. This paper examines emerging techno-lifeworlds in remote villages in Malaysia and their social, economic and political context through a new materialist lens. I argue that the entanglements with digital technologies and the resulting diffractions can result in increased agency for those involved. At the same time as this new materialist focus emphasizes the agentic role of devices and infrastructure, it allows for thinking through the power relationships that are implicated in the regional techno-politics and the economic and political interests that determine the material access to communications infrastructure.
Analytic approximation for Jaynes-Cummings revivals
Authors: Carmichael Howard J. 
Published: November 2023

Recent interest in the collapse and revival of Rabi oscillations in the Jaynes-Cummings model was stimulated by a paper in 1980 by Eberly et al.1 These authors presented an analytic expression for the inversion of a two-level atom interacting with a single mode of the radiation field taken to be initially in a coherent state. Their analytic expression agreed well with a numerical evaluation of the standard summation formula for the inversion. Since the publication of this analytic result various discussions of its proof have appeared. Existing versions of the proof all convert the summation formula into an integral and evaluate this integral using the method of stationary phase.2 This approach is mathematically intricate and leaves one with little physical intuition for the approximations that are made. I offer an alternative proof, which, in compact form, takes only a few lines. The proof is built up in a series of approximations based on an expansion of the troublesome square root
(n) in the Jaynes-Cummings summation formula in a Taylor series about the mean photon number:

n=n¯[1+12n−n¯n¯−18(n−n¯n¯)2+…].
The analytical expression of Eberly ef al. is recovered using standard sums and integrals and this Taylor expansion to second order.
Ultrahigh resolution spectroscopy of free radicals
Authors: Miller Terry A. 
Published: November 2023

Rotationally resolved electronic spectra of moderately large free radicals such as CH3O, C2H5O, C5H5, and
C6 F6+ have been obtained by using a pulsed amplified tunable ring dye laser system. This system is capable of producing laser radiation of moderately high energy, 5–10 mJ/pulse throughout the visible spectral region, and may be doubled into the UV. The radicals are produced by excimer laser photolysis of suitable precursors in a supersonic free jet expansion. Spectra of radicals with internal temperatures in the range of ~0.5–20 K have been recorded. The analyses of these spectra to obtain information about the radicals' geometries and electronic structure are discussed.
Detection of coinfection with Primate Erythroparvovirus 1 and arboviruses (DENV, CHIKV and ZIKV) in individuals with acute febrile illness in the state of Rio Grande do Norte in 2016
Authors: Morais Vanessa dos Santos , Reis Santana Lídia Maria , Bezerra João Felipe , Cruz Flavia Emmanuelle , Rocha de Souza Themis , Tahmasebi Roozbeh , Alves Raposo Rafael Augusto , Marcatti Roberta , Garcia Barbosa Erick Matheus , Hefford Philip Michael , Buccheri Renata , Cerdeira Sabino Ester , Charlys da Costa Antonio 
Published: November 2023

Background
Arthropod-borne viruses, known as arboviruses, pose substantial risks to global public health. Dengue (DENV), Chikungunya (CHIKV) and Zika (ZIKV) viruses stand out as significant concerns in Brazil and worldwide. Their overlapping clinical manifestations make accurate diagnosis a challenge, underscoring the need for reliable laboratory support. This study employs a comprehensive molecular diagnostic approach to track viral infections in individuals with acute febrile illness, a period marked by widespread outbreaks of DENV, CHIKV and ZIKV.

Methods
Between January and August 2016, we received a total of 713 serum samples obtained from individuals with acute febrile illness, previously tested for DENV, CHIKV or ZIKV, with initial negative results, from LACEN-NATAL. Of the total 713 samples, 667 were from females (354 of them pregnant) and 46 from males. Molecular diagnosis was conducted using the Multiplex RT-qPCR technique for simultaneous detection of DENV, CHIKV and ZIKV. Additionally, we performed differential diagnosis by RT-qPCR for other viruses of the Flavivirus, Alphavirus Enterovirus genera and qPCR for Primate Erythroparvovirus 1 (B19V) species, in accordance with Ministry of Health guidelines.

Results
Among the 713 cases, 78.2% tested positive for viral infections, including 48% with CHIKV viremia, 0.6% with DENV and 0.1% with ZIKV. Arboviral coinfections totaled 2.4%, including DENV-CHIKV (1.7%) and CHIKV-ZIKV (0.7%). Moreover, 8% exhibited B19V viremia. Simultaneous infections were identified in 17.5%, encompassing B19V-CHIKV (17.1%), B19V-DENV (0.1%), and B19V-ZIKV (0.3%) Triple infections were observed in 1.3% of cases with B19V-DENV-CHIKV (1%) and B19V-CHIKV-ZIKV (0.3%).

Conclusion
Molecular testing demonstrated high efficacy in diagnosing prevalent arboviruses and detecting multiple coinfections. This approach helps to elucidate etiologies for symptomatic cases, especially during arbovirus outbreaks, and aids comprehensive surveillance. Our findings underscore the importance of monitoring co-circulating pathogens, such as B19V, with implications for clinical management, particularly in pregnant individuals. This study enhances our understanding of arbovirus epidemiology and reinforces the critical role of molecular diagnosis in disease surveillance and control.
Functional recovery of chronically critically ill patients in the first days after discharge from the intensive care unit: Feasibility of the 6-minute step test
Authors: Roccasecca Sampaio Gaia Viviane , Costa Eduardo Leite Vieira , Yamaguti Wellington Pereira , Francisco Davi de Souza , Fumis Renata Rego Lins 
Published: November 2023

Background
Survivors of chronic critical illness often experience weakness and functional dependence to various degrees after their intensive care unit (ICU) stay. Evaluating their functional status with the traditional six-minute walk test is challenging due to space constraints or patient intolerance.

Objective
Our aim was to evaluate the feasibility of using the six-minute step test (6MST) as a measure of functional capacity in chronically critically ill patients early after ICU discharge.

Methods
This prospective study was undertaken in a private Brazilian hospital. From July 2019 to July 2020, all chronically critically ill patients were asked to participate 48 hours after ICU discharge. On the day of study inclusion and a week later, those who consented underwent functional assessment comprised of the 6MST, peripheral muscle strength using handgrip strength (HGS), and mobility using the ICU mobility scale (IMS).

Results
A total of 40 patients were included. The 6MST was feasible in 40% on the first evaluation and 57% on the second. The median 6MST was 0 [0–5] on the first evaluation and 3.5 [0–7.75] on the second (P = 0.005). The median HGS increased from 11.50 [9.25–18] on the first evaluation to 14.5 [10–20] on the second (P = 0.006). The median IMS was 4.5 [3.25–7] on the first evaluation and 6 [3.25–7] on the second (P<0.001). Despite the significant improvement, all parameters measured remained well below normal.

Conclusion
The 6MST was a feasible measure of functional capacity in chronically critically ill patients early after ICU discharge. Patients had functional capacity well below predicted values.
Beyond the Usual Diet: A Challenging Case of Xylophagia Resulting in Intestinal Obstruction From Xylobezoar
Authors: Shah Yash R. , Narsapuram Parikshit , Krishnamoorthy Geetha , Mansour Ramy 
Published: November 2023

ABSTRACT
Xylobezoar is indeed a rare condition associated with xylophagia, characterized by varying degrees of intestinal obstruction due to the entrapment of undigested paper in the gastrointestinal tract. Xylophagia is a form of pica that primarily affects children from low socioeconomic backgrounds with mental conditions and nutritional deficiencies. It is rarely seen in adults. Medical and endoscopic interventions are often challenging in these patients, and surgical intervention is often required. We present an endoscopically challenging case of pancolonic obstruction due to toilet paper accumulation in a patient with pica secondary to iron deficiency anemia.
Important application value of injectable hydrogels loaded with omeprazole Schiff base complex in the treatment of pancreatitis
Authors: Ma Jingrong , Du Chaoqun , Zhang Yuehua , Zhan Jing , Lai Yafang , Zhao Mingwei 
Published: November 2023

Abstract
In this study, a novel Ho(iii) coordination complex with the chemical composition of [Ho6(acac)4L4(CH3O)6]·xCH3OH (1) has been prepared via using a polydentate Schiff base ligand N′-(2,3-dihydroxybenzylidene) picolinohydrazide (H2L) and a β-diketone (Hacac = acetylacetone) co-ligand, and then successfully loaded with drug omeprazole. Hyaluronic acid, a natural polysaccharide with good biocompatibility, was used as raw material to prepare drug carriers that can be injected into hydrogels based on chemical synthesis method. The internal microstructure of the hydrogel was observed by scanning electron microscope, which showed a good three-dimensional connected porous structure. After the synthesis of the hydrogel, the value of their application in the treatment of pancreatitis was evaluated and the related mechanisms were explored at the same time.
Rapid tooling of composite aluminium filled epoxy mould for injection moulding of polypropylene parts with small protruded features
Authors: Todmal Abhinay S. , Deshmukh Bhojraj D. , Shaikh Mohemmed Suleman Noor Mohemmed , Ahuja Bharatkumar B. 
Published: November 2023

Abstract
Rapid tooling evolved from rapid prototyping is a novel method for developing prototype tooling rapidly using various additive manufacturing techniques. Traditional injection moulding is unsuitable for low-volume production because of the high initial cost. This study is focused on a rapid tooling approach for producing an injection mould insert for the low-volume production of plastic components. A plastic injection mould insert is designed, developed using composite aluminium filled epoxy with minute protruded features and tested on a vertical injection moulding machine as a rapid tool for low-volume production of plastic components. The composite aluminium filled epoxy (CAFE) mould insert is prepared using a wax master from silicon rubber mould prepared using a stereolithography master. Experiments are performed to determine the optimum mixing ratio of epoxy: aluminium powder for making the composite aluminium filled epoxy injection mould. The mould insert prepared was tested for the injection of polypropylene components on a vertical injection moulding machine and analyzed for dimensional accuracy. The analysis of dimensional accuracy and viability of minute features on the injected parts shows promising results for up to 30 injected parts. The injection of parts after 30 pieces resulted in increasing mould erosion and pitting, causing mould damage at the 36th injection shot. The experimental finding supports the feasibility of using the composite aluminium filled epoxy injection mould for low-volume production of the parts; however, the surface finish is inferior. The life of the mould is expected to give better results with a higher surface finish. It is also exposed that using mould release agents improves the life of the composite aluminium-filled epoxy injection mould.
Does intestinal anastomosis in resection of colon cancer have a significant impact onto early postoperative outcome and long-term survival?
Authors: Hajduk Ellen , Meyer Frank , Otto Ronny , Croner Roland , Ridwelski Karsten 
Published: November 2023

Abstract

Objectives
To investigate the influence of anastomosis on the early postoperative and long-term oncological outcomes of patients with primary colon carcinoma (CA).

Methods
All consecutive patients with the histologically diagnosed primary colon CA (design, prospective multicenter observational study) were registered with regard to patient-, diagnostic-, tumor (Tu) finding-, and treatment-related aspects using a computer-based registry with 60 items to characterize early postoperative and long-term oncological outcome.

Results

Basic data: From 2010 to 2016, data from a total of 14,466 patients were documented (mean age, 72.8 [range, 22–96] years; sex ratio, m:f=7,696:6,770). – 717/14,466 patients (4.96 %) were included in a matched-pair analysis. The majority of these patients underwent elective surgery (n=12,620 patients; 87.2 %) regardless of whether a bowel anastomosis or an ostomy was created. In emergency surgery, a bowel anastomosis was possible in a large proportion (n=1,332 patients [72.1 %]). In contrast, in 514 patients (27.9 %) who underwent emergency surgery, an ostomy was created. Interestingly, ostomy had to be created even less frequently in patients who had undergone planned surgery (n=366 [2.5 %]). – Early postoperative outcome: Cases of postoperative mortality were mainly due to general complications. Especially among the patients treated in an emergency situation without intestinal anastomosis, a high proportion died of their pre-existing condition (17.0 %). Patients who underwent ostomy creation or emergency surgery had a worse risk profile (incl. arterial hypertension, diabetes mellitus, and secondary cardiac or renal diseases) which led to the decision to operate without anastomosis. Furthermore, data show no matter which technique had been used, patients that had undergone surgical intervention without anastomosis were more likely to develop complications. – Long-term oncosurgical outcome: The most important factors influencing long-term survival were age, resection status, and tumor stage (according to TNM and UICC). The more advanced the tumor growth, the lower the long-term survival. Patients categorized with the same tumor stage, age, and risk factors had a better chance of survival, if they underwent elective surgical intervention and with intestinal anastomosis. Interestingly, the multivariable analysis showed that older patients and such with distant metastasis benefit from a discontinuity resection.

Conclusions
The association of intraoperative and postoperative complications with increased postoperative mortality, as well as preexisting risk factors and perioperative complications is in line with findings of current studies. Furthermore, current studies also agree that older patients and such with reduced general condition benefit from discontinuity resection.
What’s the News About Bad News? A Review of Bad News Games as a Tool to Teach Media Literacy
Authors: Barabas Rebecca 
Published: November 2023

AbstractThis paper examines theBad Newsseries of games, created by the Cambridge University Social Decision Making Lab and DROG Group, as an educational tool. More specifically, it considersBad Newsas a persuasive game, within the umbrella of gamification. After considering the history and context of the game, the educational, motivational, and informational theoretical frameworks of the games, research, and criticisms, this paper concludes that the games are not, in themselves, transformative.
Crystal structure of dicarbonyl[N,N′-(1,2-dimethyl-1,2-ethanediylidene)bis[2,6-bis(1-methylethyl)benzenamine]-N,N′]nickel(0), C30H40N2NiO2
Authors: Shen Lingyi , Xu Na , Jiang Mengna , Zhao Jiang , Xu Xiaoling , Yang Xian-Jiong , Zhang Qi-Long 
Published: November 2023

Abstract
C30H40N2NiO2, orthorhombic, Pnma (no. 62), a = 12.8114(19) Å, b = 21.301(3) Å, c = 10.6536(16) Å, V = 2907.3(8) Å3, Z = 4, R
gt(F) = 0.0290, wR
ref(F
2) = 0.0808, T = 273(2) K.
MICa/b‐dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to autoimmunity
Authors: Sánchez‐Cerrillo Ildefonso , Calzada‐Fraile Diego , Triguero‐Martínez Ana , Calvet‐Mirabent Marta , Popova Olga , Delgado‐Arévalo Cristina , Valdivia‐Mazeyra Mariel , Ramírez‐Huesca Marta , de Luis Enrique Vázquez , Benguría Alberto , Aceña‐Gonzalo Teresa , Moreno‐Vellisca Roberto , de Llano Magdalena Adrados , de la Fuente Hortensia , Tsukalov Ilya , Delgado‐Wicke Pablo , Fernández‐Ruiz Elena , Roy‐Vallejo Emilia , Tejedor‐Lázaro Reyes , Ramiro Almudena , Iborra Salvador , Sánchez‐Madrid Francisco , Dopazo Ana , Álvaro Isidoro González , Castañeda Santos , Martin‐Gayo Enrique 
Published: November 2023

AbstractPrimary Sjögren's syndrome (pSS) is an inflammatory autoimmune disorder largely mediated by type I and II interferon (IFN). The potential contribution of innate immune cells, such as natural killer (NK) cells and dendritic cells (DC), to the pSS pathology remains understudied. Here, we identified an enriched CD16+ CD56hi NK cell subset associated with higher cytotoxic function, as well as elevated proportions of inflammatory CD64+ conventional dendritic cell (cDC2) subtype that expresses increased levels of MICa/b, the ligand for the activating receptor NKG2D, in pSS individuals. Circulating cDC2 from pSS patients efficiently induced activation of cytotoxic NK cells ex vivo and were found in proximity to CD56+ NK cells in salivary glands (SG) from pSS patients. Interestingly, transcriptional activation of IFN signatures associated with the RIG‐I/DDX60 pathway, IFN I receptor, and its target genes regulate the expression of NKG2D ligands on cDC2 from pSS patients. Finally, increased proportions of CD64hi RAE‐1+ cDC2 and NKG2D+CD11b+CD27+ NK cells were present in vivo in the SG after poly I:C injection. Our study provides novel insight into the contribution and interplay of NK and cDC2 in pSS pathology and identifies new potential therapy targets.