bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prodromal symptoms of rheumatoid arthritis in a primary care database: variation by ethnicity and socioeconomic status
Authors: d’Elia Alexander , Baranskaya Aliaksandra , Haroon Shamil , Hammond Ben , Adderley Nicola J , Nirantharakumar Krishnarajah , Chandan Joht Singh , Falahee Marie , Raza Karim 
Published: November 2023

AbstractObjectivesTo assess whether prodromal symptoms of rheumatoid arthritis (RA), as recorded in the Clinical Practice Research Datalink Aurum (CPRD) database of English primary care records, differ by ethnicity and socioeconomic status.MethodsA cross-sectional study to determine the coding of common symptoms (≥0.1 % in the sample) in the 24 months preceding RA diagnosis in CPRD Aurum, recorded between January 1st2004 to May 1st2022. Eligible cases were adults with a code for RA diagnosis. For each symptom, a logistic regression was performed with the symptom as dependent variable, and ethnicity and socioeconomic status as independent variables. Results were adjusted for sex, age, BMI, and smoking status. White ethnicity and the highest socioeconomic quintile were comparators.ResultsIn total, 70115 cases were eligible for inclusion, of which 66.4 % female. Twenty-one symptoms were coded in more than 0.1 % of cases so were included in the analysis. Patients of South Asian ethnicity had higher frequency of codes for several symptoms, with the largest difference by odds ratio being muscle cramps (OR 1.71, 1.44-2.57) and shoulder pain (1.44, 1.25-1.66). Patients of Black ethnicity had higher prevalence of several codes including unintended weight loss (2.02, 1.25-3.28) and ankle pain (1.51, 1.02-2.23). Low socioeconomic status was associated with morning stiffness (1.74, 1.08-2.80) and falls (1.37, 2.03-1.82)ConclusionThere are significant differences in coded symptoms between demographic groups, which must be considered in clinical practice in diverse populations and to avoid algorithmic bias in prediction tools derived from routinely collected healthcare data.Key messages-There are differences in symptom reporting in new onset rheumatoid arthritis across ethnic groups.-These differences should be considered in clinical practice in diverse populations.-The findings are relevant in avoiding bias in prediction tools derived from healthcare data.
The association between chrononutrition behaviors and muscle health among older adults: The Study of Muscle, Mobility and Aging (SOMMA)
Authors: Mao Ziling , Cawthon Peggy M , Kritchevsky Stephen B , Toledo Frederico G S , Esser Karyn A , Erickson Melissa L , Newman Anne B , Farsijani Samaneh 
Published: November 2023

ABSTRACTBackgroundEmerging studies highlight chrononutrition’s impact on body composition through circadian clock entrainment, but its effect on older adults’ muscle health remains largely overlooked.ObjectiveTo determine the associations between chrononutrition behaviors and muscle health in older adults.MethodsDietary data from 828 older adults (76±5y) recorded food/beverage amounts and their clock time over the past 24 hours. Studied chrononutrition behaviors included:1)The clock time of the first and lastfood/beverage intake;2)Eating window(the time elapsed between the first and last intake); and3)Eating frequency(Number of self-identified eating events logged with changed meal occasion and clock time). Muscle mass (D3-creatine), leg muscle volume (MRI), grip strength (hand-held dynamometer), and leg power (Keiser) were used as outcomes. We used linear regression to assess the relationships between chrononutrition and muscle health, adjusting for age, sex, race, marital status, education, study site, self-reported health, energy, protein, fiber intake, weight, height, and moderate-to-vigorous physical activity.ResultsAverage eating window was 11±2 h/d; first and last intake times were at 8:22 and 19:22, respectively. After multivariable adjustment, a longer eating window and a later last intake time were associated with greater muscle mass (β±SE: 0.18±0.09; 0.27±0.11, respectively,P<0.05). The longer eating window was also marginally associated with higher leg power (P=0.058). An earlier intake time was associated with higher grip strength (−0.38±0.15;P=0.012).ConclusionsChrononutrition behaviors, including longer eating window, later last intake time, and earlier first intake time were associated with better muscle mass and function in older adults.GRAPHICAL ABSTRACTKey findingsChrononutrition behaviors, including longer eating window, later last intake time, and earlier first intake time were associated with better muscle mass and function in older adults.
Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy
Authors: Cagnone Gael , Pundir Sheetal , Sung-Kim Jin , Rivera José Carlos , Agnihotri Tapan , Harvey Noémie-Rose , Heckel Emilie , Betus Charlotte , Chen Mei Xi , Situ Anu , Gaub Perrine , Kim Nicholas , Das Ashim , Leclerc Severine , Wünnemann Florian , Andelfinger Gregor , Crespo-Garcia Sergio , Dubrac Alexandre , Rezende Flavio , Clish Clary B. , Maranda Bruno , Smith Lois E. H. , Sapieha Przemyslaw , Joyal Jean-Sébastien 
Published: November 2023

ABSTRACTHealthy blood vessels supply neurons to preserve metabolic function. In blinding ischemic proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological neuroretina revascularization. We show that metabolic shifts in the neurovascular niche define this angiogenic dichotomy between healthy and diseased blood vessel growth. Fatty acid oxidation (FAO) metabolites accumulated in human and murine retinopathy samples. Neovascular tufts with a distinct single-cell transcriptional signature highly expressed FAO enzymes. The deletion ofSirt3, an FAO regulator, shifted the neurovascular niche metabolism from FAO to glycolysis and suppressed tuft formation. This metabolic transition increasedVegfexpression in astrocytes and reprogrammed pathological EC to a physiological phenotype, hastening vascular regeneration of the ischemic retina. Our findings identify SIRT3 as a metabolic switch in the neurovascular niche, offering a new therapeutic target for optimizing ischemic tissue revascularization.HighlightsPathological EC favor FAO over glycolysis.Unique signature for pathological EC found in proliferative retinopathy model.Sirt3deletion shifts astrocytes and EC metabolism from FAO to glycolysis.Metabolic reprogramming of the vascular niche enhances physiological revascularization.Graphical Abstract
Workplace tele pressure and innovative work performance. A moderation mediation study through work-family conflicts and job burnout
Authors: Aman-Ullah Attia , Aziz Azelin , Ariza-Montes Antonio , Han Heesup 
Published: November 2023

PurposeThis study explores the impact of workplace tele pressure on innovative work performance. The study also tests the mediating effect of the work-family conflict and the moderating influence of job burnout between the work-family conflict and innovative work performance.Design/methodology/approachData for the present study were collected through structured questionnaires from 285 employees working in the public and private sector universities. Data were analysed through SPSS and Smart-PLS.FindingsResults confirmed the relationship between workplace tele pressure and innovative work performance, the mediating effect of work-family conflict between workplace tele pressure and innovative work performance and the moderating influence of job burnout between work-family conflicts and innovative work performance.Originality/valueThis study model is supported by the job demands-control model and effort-recovery theory, which is being tested for the first time to support the relationship between workplace tele pressure and innovative work performance. Further, the model “workplace tele pressure → work-family conflicts → job burnout → innovative work performance” was developed and tested for the first time to study the technology-based pressure in the education sector.
Client influence or the valuer's behavior? An empirical study of listed companies' valuation in Taiwan
Authors: Chen Fong-Yao , Mak Michael Y. 
Published: November 2023

PurposeValuers should independently assess market value. The purpose of this article is to analyze whether the valuation behavior remains independent when commissioned by publicly listed companies in Taiwan.Design/methodology/approachThis study used both quantitative and qualitative methods. Quantitative data analysis was used to examine the estimated premium ratio and estimated divergent ratio with the independent sample t test and Wilcoxon-Mann-Whitney test. To complement and validate the quantitative analysis, open-ended questionnaires were conducted, providing additional insights into the research findings.FindingsThe results showed that there is a significant difference in estimated valuations commissioned by representatives of buyers and sellers, and the estimated premium ratios commissioned by representatives of buyers were higher than those of sellers. Furthermore, the open-ended questionnaires results indicate that these findings may be influenced by clients for less experienced appraisers. However, for senior appraisers, this is seen as an action to gain a better understanding of the valuation purpose and always within a reasonable price range. In addition, client influence is not a static factor; it may transform into the valuer's behavior as the appraiser's experience grows and deepens.Practical implicationsIt is difficult to obtain valuation reports commissioned by representatives of both buyers and sellers for the same property transactions. In this study, data were obtained from the Market Observation Post-System (MOPS) in Taiwan. As valuation reports could not be obtained, estimated valuations and transaction prices are used to calculate estimated premium ratio and estimated divergent ratios.Originality/valuePrevious investigations of the client effect have been conducted using qualitative methods including questionnaire surveys, in-depth interviews and experimental design. However, these studies are subject to moral hazard. This study may be the first study that has access to data on valuations for both buyers and sellers in such a formal setting.
Passion and intention among aspiring entrepreneurs with disabilities: the role of entrepreneurial support programs
Authors: Dakung Reuel Johnmark , Bell Robin , Orobia Laura Aseru , Dakung Kasmwakat Reuel , Yatu Lemun Nuhu 
Published: November 2023

PurposeThis study examines the relationship between entrepreneurial passion, entrepreneurial support programs and entrepreneurial intention, and the moderating role of entrepreneurial support programs in the relationship between entrepreneurial passion and entrepreneurial intention, among students with physical disabilities in Nigerian tertiary institutions.Design/methodology/approachThis study used a closed-ended questionnaire survey, composed of previously validated scales, to sample 209 students with physical disabilities at tertiary institutions in Nigeria. Hierarchal regression was performed to assess the relationships between the variables and test the hypotheses.FindingsBoth entrepreneurial passion and entrepreneurial support programs were found to be significantly positively related to entrepreneurial intention, and entrepreneurial support programs also moderated the relationship between entrepreneurial passion and entrepreneurial intention.Research limitations/implicationsThis research paper identifies that developing entrepreneurial passion and providing accessible and inclusive entrepreneurial support programs are valuable in supporting and facilitating a passage into entrepreneurship for those with disabilities.Originality/valueThis research paper addresses calls for further understanding of how those with disabilities can be supported into entrepreneurship, by identifying supporting factors. The research paper provides further understanding of the entrepreneurial passion and intention nexus by exploring the relationship within those with a physical disability, where significant barriers exist and within a developing country context where entrepreneurship might be a necessity rather than driven by passion.
Favouritism: a recipe for ostracism? How jealousy and self-esteem intervene
Authors: Mohd Shamsudin Faridahwati , Bani-Melhem Shaker , Abukhait Rawan , Aboelmaged Mohamed , Pillai Rekha 
Published: November 2023

PurposeOstracism is a common challenge in the workplace, but little is known about the behaviours of those who trigger it. The authors examined how leader favouritism can drive coworkers to ostracise one another, given that leadership is a key factor in shaping employee attitudes and behaviour. Invoking social comparison theory, the authors assessed a model of how perceived favouritism affects ostracism through jealousy, moderated by organisation-based self-esteem (OBSE).Design/methodology/approachThe authors surveyed 294 non-managerial employees from several service organisations in the United Arab Emirates (UAE) and analysed the data with partial least squares structural equation modelling (PLS-SEM) using SmartPLS 3 software.FindingsUnexpectedly, leader favouritism did not directly affect ostracism but only indirectly through the mediation of jealousy. OBSE was found to moderate this relationship, suggesting that higher levels of OBSE can weaken the impact of leader favouritism on employee jealousy.Originality/valueThese findings explain the intricate dynamics and underlying reasons as to how leader favouritism can instigate employee-to-employee ostracism.
Microbial iron acquisition is influenced by spatial and temporal conditions in a glacial influenced river and estuary system
Authors: Brauner Megan , Briggs Brandon R. 
Published: November 2023

AbstractIn Arctic regions, glaciers are major sources of iron to rivers and streams; however, estuaries are considered iron sinks due to the coagulation and flocculation processes that occur at higher salinities. It is unknown how iron dynamics in a glacial influenced river and estuary environment affect microbial mechanisms for iron acquisition. Microbial taxonomic and functional sequencing was performed on samples taken throughout the year from the Kenai River and the estuary, Alaska. Despite distinct iron, sodium, and other nutrient concentrations, the river and estuary did not have statistically different microbial communities nor was time of sampling significant. However, ferrous iron transport (Feo) system genes were more abundant in river environments, while siderophore genes were more abundant and diverse in estuary environments. Siderophore transport and iron storage genes were found in all samples, but gene abundance and distribution were potentially influenced by physical drivers such as discharge rates and nutrient distributions. Differences in iron metabolism between river and estuary ecosystems indicate environmental conditions drive microbial mechanisms to sequester iron. This could have implications for iron transport as the Arctic continues to warm.
Large carnivore distribution, conflicts and threats in the east of the Somali region, Ethiopia
Authors: Abdella Fedlu , Hailu Abiot , Tilahun Shibru , Johnson Paul J. , Bauer Hans 
Published: November 2023

AbstractLarge carnivore distribution in Ethiopia is not well documented; we did 108 interviews and 12 focus group discussions in six districts of the Somali Region to gather basic information. The Region is not listed as resident range for big cats, but our results indicate widespread presence of cheetah, and possible remnants of lion and leopard occurrence. Spotted and striped hyaena, plus many smaller species, are frequently encountered. In contrast to positive attitudes towards wild grazers, all carnivores are persecuted in response to frequent conflict leading to injuries and deaths among people and livestock. Lion and cheetah cubs were regularly captured and trafficked, and this may have contributed to lion declines especially. Cheetah cubs are still regularly caught and we mapped how they are smuggled to Somalia/Somaliland from where they enter the pet trade.
Economic equity and people with disabilities: Development and characterization of a novel index
Authors: Walia Bhavneet , McDonald Katherine , Hammel Joy , Frieden Lex , Morris Michael , Whaley Barry , Nguyen Vinh 
Published: November 2023

AbstractHere, we develop two new social indices: the ADA PARC Absolute Economic Opportunity Index and the ADA PARC Relative Economic Opportunity Index. These indices allow us novel examinations of economic equity between people with and without disabilities within a U.S. state and between people with disabilities in different states using aggregations of multiple component economic indicators. These represent the first efforts to offer U.S. indices of this focus, an important development given the distinct economic needs of people with disabilities and the value in accounting for distinct national policies. The indices rely on U.S. Census and other data on economic opportunity by population. These indices provide comprehensive insight into economic disparities between people with and without disabilities and among people with disabilities in the United States. We find that state/territory values for the two indices are moderately positively correlated, suggesting that relative and absolute economic opportunity for people with disabilities arise from both common and distinct processes. Policy implications for low economic opportunity states are discussed.
Parental views on universal asset‐building policy for all children
Authors: Huang Jin , Beverly Sondra G. , Clancy Margaret M. , Sherraden Michael 
Published: November 2023

AbstractFinancial incentives and support have positive impacts on child development and health. The brief uses data collected from a randomized experiment to examine parents' views of child development accounts (CDAs), a universal asset‐building policy to deliver financial subsidies for adolescent development, education, health and other developmental outcomes. Parents in the treatment and control groups have similar views on the universal CDA policy model, and more than 80% of them supported nine tested policy features of CDAs. Public opinion reflected in parents' views is critical for successful policymaking of such policies for children and families in the future.
Association between nutritional status and gait performance in Alzheimer's disease
Authors: He Mingyue , Lian Tenghong , Guo Peng , Zhang Yanan , Huang Yue , Qi Jing , Li Jinghui , Guan Huiying , Luo Dongmei , Liu Zhan , Zhang Weijia , Zheng Zijing , Yue Hao , Li Jing , Zhang Wenjing , Wang Ruidan , Zhang Fan , Wang Xiaomin , Zhang Wei 
Published: November 2023

AbstractAimsThis study aimed to comprehensively explore the nutrition and gait of AD patients at different stages and the relationship between them.MethodsA total of 85 AD patients were consecutively enrolled in this cross‐sectional study and divided into the mild cognitive impairment (MCI) due to AD (AD‐MCI) and the dementia due to AD (AD‐D) groups. Demographic information, nutritional status, and gait performance were compared between the two groups, and the correlation between nutritional status and gait performance was subsequently analyzed by Pearson and Spearman correlation analyses.ResultsThe AD‐D group had lower scores on Mini‐Nutritional Assessment (MNA) and MNAm scales, lower levels of urea nitrogen, folic acid, and vitamin B12 in blood, and higher homocysteine level than those in the AD‐MCI group (all p < 0.05). The AD‐D group had slower step speed, shorter step length, and shorter stride length than those in the AD‐MCI group (all p < 0.05). AD patients with decreased scores of MNA and MNAm scales, and declined levels of urea nitrogen and vitamin B12 in blood had reduced gait speed and gait cadence, and prolonged step length time and stride length time, whereas homocysteine showed the almost opposite results (all p < 0.05). In the AD‐MCI group, the score of scale was negatively correlated with the coefficient of variation (CV) of stride length, and the folic acid level was negatively correlated with the CV of stride length and cadence (all p < 0.05).ConclusionsAD patients at the dementia stage had worse nutritional status and gait performance than those at the MCI stage, which was associated with worse global cognition and activities of daily living. Poorer nutritional status was associated with higher gait variability in patients at the MCI stage and with poorer gait performance in patients at the dementia stage. Early identification and intervention of patients with nutritional risk or malnutrition may improve gait performance, thus reducing the risk of falling and cognitive decline, as well as the mortality.
Asymmetric deep cerebral venous filling predicts poor outcome of acute basilar artery occlusion after endovascular treatment
Authors: Wang Huiyuan , Shen Panpan , Yu Xinyue , Shang Yafei , Xu Jie , Chen Xinyi , Tan Mingming , Lin Longting , Parsons Mark , Zhang Sheng , Geng Yu 
Published: November 2023

AbstractObjectiveTo explore the relationship between asymmetric deep cerebral venous (ADCV) filling and poor outcomes after endovascular treatment (EVT) in patients with acute basilar artery occlusion (ABAO).MethodsABAO patients were selected from a prospectively collected data at our center. The DCV filling was evaluated using computed tomography perfusion (CTP)‐derived reconstructed 4D‐DSA or mean venous map. ADCV filling was defined as the internal cerebral vein (ICV), thalamostriate vein (TSV), or basal vein of Rosenthal (BVR) presence of ipsilateral filling defects or delayed opacification compared to the contralateral side. Poor prognosis was defined as a modified Rankin scale score >3 at the 90‐day follow‐up.ResultsA total of 90 patients were enrolled in the study, with a median Glasgow Coma Scale of 6, 46 (51.1%) showed ADCV filling, 59 (65.6%) had a poor prognosis, and 27 (30.7%) had malignant cerebellar edema (MCE). Multivariate adjusted analysis revealed significant associations between asymmetric TSV and poor prognosis (odds ratio, 9.091, p = 0.006); asymmetric BVR (OR, 9.232, p = 0.001) and asymmetric ICV (OR, 4.028, p = 0.041) were significantly associated with MCE.ConclusionPreoperative ADCV filling is an independent influencing factor for the poor outcome after EVT in ABAO patients.
Face Age is Mapped Into Three‐Dimensional Space
Authors: Dalmaso Mario , Pileggi Stefano , Vicovaro Michele 
Published: November 2023

AbstractPeople can represent temporal stimuli (e.g., pictures depicting past and future events) as spatially connoted dimensions arranged along the three main axes (horizontal, sagittal, and vertical). For example, past and future events are generally represented, from the perspective of the individuals, as being placed behind and in front of them, respectively. Here, we report that such a 3D representation can also emerge for facial stimuli of different ages. In three experiments, participants classified a central target face, representing an individual at different age stages, as younger or older than the reference face of 40 years. Manual responses were provided with two keys placed along the horizontal axis (Experiment 1), the sagittal axis (Experiment 2), and the vertical axis (Experiment 3). The results indicated that the younger faces were represented on the left/back/top side of the space, whereas the older faces were represented on the right/forward/bottom side of the space. Furthermore, in all experiments, the latencies decreased with the absolute difference between the age of the target face and that of the reference face (i.e., a distance effect). Overall, this work suggests that the spatial representation of time includes social features of the human face.