bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors Affecting the Death of Hospitalized Patients with COVID-19 in the South of Iran
Authors: Sardu Ehsan Goroei , Davarani Fatemeh Rezabeigi , Kermani Bahareh , Faryabi Reza , Kargar Shiva , Tashakori Shamim , Daneshi Salman 
Published: December 2023

Background: Identifying effective factors in death caused by the infection of COVID-19 is one of the most worrisome issues in the globe. This study aims to investigate the frequency of risk factors leading to death in patients with COVID-19.
Methods: This was a retrospective descriptive study done on 150 confirmed cases of COVID-19 in Imam Khomeini Hospital in Jiroft in 2019. Patients were included in the study by census method. The required information was extracted and recorded in the researcher's checklist; which included demographic and social characteristics of patients (age, gender, smoking, and opium consumption), underlying disease,test results (leukopenia, leukocytosis, neutropenia, decrease in albumin, increase in creatinine, ALT, AST, LDH and CRP), and the RT-PCR test.,. The researchers analyzed data using independent sample t-test, and chi-square by SPSS-V22.
Results: The mean age of the patients was 72.19 ± 15.97. Most of those who died with COVID-19 were men. There was a statistically significant relationship between the use of drugs and the death of patients with COVID-19(P-value<0.05). The average body mass index (BMI) of the confirmed patients was 31.14 ± 7.08 kg/m2 in the overweight group (P-value<0.001). Moreover, there was a significant relationship between the risk factors CRP, ALB, AST, ALT, Cr, lym, Neut, WBC and inevitable death in patients with COVID-19(P-Value<0.001). Regarding underlying diseases, diabetes, lung, and kidney diseases have been observed in most terminal patients (P-value<0.001).
Conclusion: Old age, male gender, high BMI, blood pressure, increased factors of CRP, AST, ALT, Cr, lym, Neut, WBC, and decreased ALB are among the risk factors leading to death in COVID-19 patients.
Introduction and adaptation of quinoa (<i>Chenopodium quinoa</i> Willd.) cultivars in Krasnodar region of Russia
Authors: Mendoza V. , Mendoza R. , Dmitriev D. V. 
Published: December 2023

Quinoa (Chenopodium quinoa Willd.) is a cultivated plant of the Amaranthaceae family of Peruvian origin with high nutritional value. The Krasnodar region of Russia is a region with favorable climatic conditions for growing quinoa. The studies were carried out on the basis of Quinoa Center LLC, located in the Novokubansky district of the Krasnodar Territory. Four quinoa varieties were used as research material: Blanca de Juli, White Peru, Salcedo, the local variety Seva (included in the State Register of the Russian Federation in 2017) served as the standard. Various morphological parameters of plants were assessed and phenological observations were carried out.The results showed statistically significant differences between varieties in plant productivity. The White Peru variety responded positively to the new conditions and was introduced without irrigation. The productivity of the panicle was on average 100 g, for the standard variety Seva - 70 g. In the dynamics of the ontogenetic development cycle of four quinoa varieties, it was established that the optimal sowing time in the conditions of the Krasnodar Territory is May. The tested varieties were also assessed for grain quality. In the conditions of the Krasnodar region they showed good results, thanks to selection for white grain and panicle uniformity. However, not all of them can be adapted, since they need constant watering and for late-ripening varieties autumn rains negatively affect their yield. The local early ripening variety Seva is of interest to Peru. In Peru, the main problem reducing production is low yield caused by frost in the Puno Peru region. The Seva variety reaches phenological phases: the beginning of panicle formation (R6), panicle formation (R7), flowering (R8) and full panicle ripening, physiological maturity (R12) and due to its early ripening it avoids frost. Therefore, the Seva variety can be recommended for sowing in the Puno-Peru region, since it has a gene pool that provides cold resistance but this requires detailed study. In general, to optimize the introduction of quinoa in Russia further research on adaptability in the Krasnodar region is necessary.
Phenolic compounds in leaves of <i>Tanacetum balsamita</i> L.
Authors: Krol T. A. , Ossipov V. I. , Baleev D. N. 
Published: December 2023

Tanacetum balsamita L. is a perennial rhizomatous plant of the Asteraceae family. T. balsamita is cultivated as medicinal, aromatic plants and food plant. Extract of costmary exhibits hepatoprotective, antiseptic and anthelmintic properties. The herb of T. balsamita contains essential oils and phenolic compounds. This species included in the "Biocollection of medicinal and aromatic plants of open and protected ground", Botanical garden of the VILAR. The main aim was to study the composition of phenolic compounds in the leaves of T. balsamita with application of ultra-performance liquid chromatography coupled with diode array detection and mass spectrometry. The object of the study was the leaves of T. balsamita. Samples were extracted with 1 ml of 80% aqueous acetone. An ultra-performance liquid chromatographic system with a photodiode detector and a triple quadrupole mass spectrometer was used for analysis of phenolic compounds. The UV and MS data of phenolic compounds were used for their identification or tentative characterization with application of mass spectrometry databases and data published in the literature.Results. The results obtained showed the presence in the leaves of 17 phenolic compounds. Five compounds were identified as caffeoylquinic, feruloylquinic and three dicaffeolquinic acid isomers, and two compounds as ferulic acid hexoside isomers. The leaves of T. balsamita contained also five luteolin derivatives, two chrysoeriol derivatives, and spinacetin/axillarin. Four compounds were not identified.
The researches of broomrape acclimatization on white cabbage in the soil-climatic conditions of Central region of the Russian Federation
Authors: Molokov B. M. , Golysheva P. Yu. 
Published: December 2023

Relevance. In one of the farms, situated in the Central region of the Russian Federation was found the first defeat of cabbage by obligate weed – broomrape. As the long experience shows (since 2011 yr.), the control of broomrape is very difficult, and it is a real danger for the vegetable growing in this region.Materials and methods. The object of researches were the plantations of white cabbage, which was grown by using the cassette technology, there were field experiments.The research methods included the following works: phenological observations of broomrape and white cabbage ontogenesis, the detection of the main features during blooming and fruiting of this weed, the definition of the duration of broomrape evolution until the fruiting phase, the detection of blooming shoots location on the surface of the cabbage plantation, the identifying of relationship between the height of broomrape’s flower-bearing shoots and the height of leaves of cabbage’s rosette.There was analyzed the feature of growing by using the cassette technology cabbage, being damaged by broomrape.Results. It was found, that the studied in the paper race of broomrape can successfully progress in more northern soil-climatic conditions of the Central region of the Russian Federation. The complex of agro technical methods of broomrape control is suggested, it includes: the two-level plowing of the weedy fields right after harvesting cabbage; receiving of cabbage’s fibrous root, which should be situated into the working plowing space with depth up to 25 cm; multiplex cultivation of the growing shoots of the weed; the cabbage hilling before rows closing. The alternative methods of broomrape control also can be used: the conveyer of cruciferous vegetable cultures with short vegetation period and cultures, which provoke the germination of the weed.
Which roads lead to access? A global landscape of six COVID-19 vaccine business models.
Authors: Ruiz Adrián Alonso , Bezruki Anna , Shinabargar Erika , Large Kaitlin , Vieira Marcela , Slovenski Iulia , Liu Yiqi , Agarwal Surabhi , Becker Anna , Moon Suerie 
Published: December 2023

Abstract
3.1. Background
Unequal and inequitable access to Covid-19 vaccines in low- and middle-income countries (L&MICs) was a major political, ethical and public health failure in the pandemic. However, vaccine developers’ practices were not monolithic, but rather, took diverse approaches to supplying different countries, with important implications for global access.
3.2. Results
Using data on R&D investments, regulatory approvals, manufacturing and purchase agreements, and vaccine deliveries, we identified six distinct business models that apply across the 14 COVID-19 vaccines with more international presence from 2020–2022. “Western Early Arrivers” Pfizer/BioNTech and Moderna supplied the largest volumes quickly and prioritized high-income countries (HICs) from registration to vaccine delivery. “Western Latecomers” Janssen and Novavax supplied intermediate volumes later, also prioritizing HICs but with a greater proportion to L&MICs. “Major Chinese Developers” Sinopharm and Sinovac supplied intermediate volumes early, primarily to middle-income countries (MICs). “Russian Developer” Gamaleya completed development early but ultimately supplied small volumes, primarily to middle-income countries (MICs). “Cosmopolitan Developer” Oxford/AstraZeneca supplied large volumes early to HICs and MICs at the lowest prices. Finally, “Small MIC Developers” CanSino, Bharat Biotech, Medigen, Finlay Institute and the Center for Genetic Engineering and Biotechnology (CGEB), exported relatively small volumes to a few MICs. Low-income countries (LICs) were not targeted by any developer, and received far fewer doses, later, than any other income group. Almost all developers received public funding and other forms of support, but we found little evidence that such support was leveraged to expand global access.
3.3. Conclusions
Each of the six business models has different implications for which countries get access to which vaccines, how quickly, and at which prices. Each offers different strengths and weaknesses for achieving equitable access. Our findings also suggest that Western firms had the greatest capacity to develop and deliver vaccines quickly during the pandemic, but such capacity is rapidly becoming more globally distributed with MICs playing a significant role, especially in supplying other MICs. Given the critical role of public support in enabling pandemic vaccine development and supply, governments have both the capacity and responsibility to craft international rules that will make responses to future pandemics more equitable and effective.
Revealing dynamic temporal regulatory networks driving cancer cell state plasticity with neural ODE-based optimal transport
Authors: Krishnaswamy Smita , Tong Alex , Kuchroo Manik , Gupta Shabarni , Venkat Aarthi , Juan Beatriz San , Rangel Laura , Zhu Brandon , Lock John , Chaffer Christine 
Published: December 2023

Abstract
Despite advances in single-cell technologies and temporal sampling, the seamless connection of cell states over time and the inference of gene-gene relationships driving cancer cell state remains a formidable challenge. We present Cflows, a framework that combines neural ordinary differential equation network designed to unravel continuous cellular dynamics from timelapsed scRNAseq data with causality analysis to learn gene regulatory networks underlying cell state changes. When applied to a novel scRNAseq data from breast cancer in vitro models, we trace cell states back to their origins, allowing us to refine a marker profile for cancer stem cells (CSCs), and compute rich and complex gene-gene networks that drive pathogenic trajectories forward. Our comprehensive temporal regulatory networks reveal the dynamic transitions along the epithelial-to-mesenchymal (EMT) and the mesenchymal-to-epithelial (MET) trajectories. Newly, we identify estrogen-related receptor alpha (ESRRA) as a critical mediator of CSC plasticity and MET cell fate decisions. We extend Cflows to an in vivo xenograft model, demonstrating its potential for elucidating trajectories governing primary tumor metastasis to the lung. In summary, Cflows is an innovative algorithm that uncovers temporal molecular programs within dynamic cell systems from static single-cell data and has helped identify key drivers and transcriptional networks underlying cancer plasticity.
Development and Performance Evaluation of a Novel Bayesian Network Model for the Classification of Heart Disease
Authors: Salman Issam , Panda Ganapati , Vomlel Jiří 
Published: December 2023

Abstract
Background: Acute myocardial infarction (AMI) is the leading cause of death world- wide and requires accurate models to predict the risk of heart disease and mortality from these accidents for early intervention and prevention.
Objective: Bayesian networks (BNs) as a class of machine learning will not only significantly improve the prediction of heart disease outcomes and its mortality, but also represent the dependence/independence between heart abnormalities, mortality and important markers. It allows analysis of healthcare quality and cost reduction.
Results: The performance of specific models was evaluated based on a comprehensive review of the existing literature, including the techniques, algorithms, and data sources used in specific studies. These findings demonstrated that machine learning has the potential to improve the assessment of heart diseases and AMI by using BNs. it shows the impact of different variables on the models’ performance.
Conclusion: Bayesian networks have redefined how we approach complex decision- making. Their ability to combine data-driven insights with probabilistic reasoning makes them essential tools for addressing classification challenges across multiple domains. As technology continues to advance, these models are likely to play an increasingly important role in improving accuracy, efficiency and decision making.
Results of thyroidectomies according to General Surgeons and Otolaryngologist and Cervico Faciale Surgeons at the General Hospital of Reference of Niamey, what differences in the protocols of management?
Authors: SAIDOU Adama , DJAFAROU Abarchi Boubé , ALFARI Abdoul Aziz , OUDOU ZABEIROU , IDE Kadi , BAKOU Owodon Gbinmigan , YOUNSSA Hama , SANI Rachid 
Published: December 2023

Abstract
Objective: To evaluate the surgical management of thyroid pathologies at the Reference General Hospital.
Methods: This was a retro-prospective study over 4 years 6 months carried out in the departments of General and Digestive Surgery (GDS) and Otorhinolaryngology and Cervico Facial Surgery (ORL/FCS). It involved 182 patients who underwent thyroid surgery.
Results: A frequency of thyroidectomy of 9.46% was found. Females predominated with a sex ratio of 0.1. The average age of patients was 42.85 years, a standard deviation 12.80. 84.06% of patients had consulted for anterior cervical mass. EU-TIRADS score 3 represented 7,14% of cases. Heteromultinodular goiter was the main indication for thyroid surgery (59.34%). Total thyroidectomy was the most commonly performed gesture in general surgery in 88,23% (n=105), in Otorhinolaryngology, it was in the same proportion as lobo-isthmectomy at 47.61% (n=30). The first route was video-assisted thyroidectomy 2.2% (n=4). The recurrent laryngeal nerve was dissected and seen in 159 cases (87.36%) and parathyroid glands were also seen and preserved in 58.24% of cases (n=106). In immediate postoperative surgery, the main complications were unilateral recurrent paralysis with dysphonia in 3.3% (n=6) and compressive hematoma in 2.2% (n=4). No deaths had been recorded.
Conclusion: Total thyroidectomy was the most performed procedure in department of General and Digestive Surgery; in Otorhinolaryngology and Cervico Facial Surgery department, conservative surgery still retains a large place. Despite the different protocols, there are few complications in both series.
Multiwavelength observations of KS 1947+300
Authors: Liu Wei , Reig Pablo , Yan Jingzhi , Zhang Peng , Li Xiukun , Gao Bo , Xiao Guangcheng , Liu Qingzhong 
Published: December 2023

Abstract
Context. KS 1947+300 is a Be/X-ray binary. Despite its nearly circular orbit, it displays both giant and regular less intense X-ray outbursts. According to the viscous decretion disk model, such low eccentric binaries should not show periodic outbursts. Aims. We have studied the long-term optical variability of KS 1947+300 and its relationship with X-ray activity. Our objective is to investigate the origin of this variability.
Methods. We have analyzed data covering more than 20 years of observations. In the optical band, we have analyzed spectra and light curves. We measured the strength of the Hα and He I 6678 Å lines. In the X-ray band, we studied the long-term light curves provided by several all-sky monitors.
Results. KS 1947+300 exhibits changes in brightness and Hα emission on time scales from months to years. The optical and IR variability shows small amplitude changes during the active X-ray state, and a long, smooth decrease during the quiescent state. The fact that the amplitude of variability increased with wavelength suggests that the long-term decrease of the optical emission is due to the weakening of the circumstellar disk. Structural changes in the disk may also be the origin of the periodic signals with periods ∼ 200 days detected in the ZTF-g and r band light curves. We speculate that these changes are related to the mechanism that ejects matter from the photosphere of the Be star into the disk. We have also studied the X-ray variability that manifested as a series of type I outbursts after the two giant outburst in 2000 and 2013 and found that the intensity and peak orbital phase differ from outburst to outburst. The type I outbursts in KS 1947+300 are not strictly periodic. This irregularity could result from precession of the interacting points between the neutron star and the disk, namely the disk apastron and the two nodes of the disk.
Conclusions. The long-term changes in optical continuum and line emission and the X-ray variability patterns are attributed to an evolving and distorted decretion disk.
Increased Risk of Low Birth Weight among Human Immunodeficiency Virus-Exposed Infants Between 2004 and 2021 in Hubei, China: A Retrospective Cohort Study
Authors: Liu Jinli , Wu Songjie , Zou Shi , Yan Yajun , Feng Ling , Guo Wei , Wu Mengmeng , Tang Weiming , Liang Ke 
Published: December 2023

Abstract

Background:Low birth weight (LBW, <2500g) is an essential indicator of neonatal death and poor infant development, but data on LBW among human immunodeficiency virus (HIV)-exposed infants in China is inadequate.
Objective: This study aimed to explore the temporal trend and factors associated with the LBW among HIV-exposed infants in Hubei province, China.
Methods: The pregnant women living with HIV in Hubei province, China between Jan 2004 and Dec 2021 were enrolled this study. Recruited HIV-positive women were provided with consultation about preventing mother-to-child transmission (PMTCT). The intervention measures for PMTCT were provided to pregnant women and HIV-exposed infants, and the LBW and HIV status of infants were followed. Collected data included women’s demographic information, HIV status of sexual partner, route of HIV transmission, HBV infection, HCV infection, syphilis infection, intrapartum CD4 count, whether received antiretroviral therapy (ART), the time of ART initiation, and ART regimens during pregnancy. Multivariable logistic regression was used to analyze factors associated with the LBW.
Results: In total, 531 mothers (581 pregnancy events) and 581 infants were enrolled. The mean birth weight and LBW rate were 3075±470.2g and 8.4%, respectively. From 2004 to 2021, a significantly increased LBW rate (4.7% to 14.0%, P=.004) was observed. The use of protease inhibitor (PI)-based regimen (P=.04) and the exposure to ART in the first trimester (P=.01) were positively correlated with the increase of LBW rate. Exposure to ART in the first trimester (adjusted odds ratio [aOR] 3.64, 95%CI 1.29-10.27) and the second trimester (aOR 4.53, 95%CI 1.52-13.48), premature delivery (aOR 48.44, 95%CI 16.98-138.18), and infant with HIV infection (aOR 5.91, 95%CI 1.55-22.58) were predictors for LBW.
Conclusions: The significantly increased LBW rate in our study indicated that specific attention should be paid to HIV-exposed infants in China. More importantly, our study identified significant factors that can predict the risk of LBW. Interventions targeting these risk factors may prevent LBW among pregnant women living with HIV in future research and prenatal care.
The development strategy of Amateur Table Tennis Match in China Based on the SWOT-AHP Model： a Case Study in Shanghai
Authors: Yi Qing , Liu Zuhong , Liu Xutao , Wang Yidan , Li Rongzhi 
Published: December 2023

Abstract

Considering the significance of amateur sports matches in health promotion and city culture construction. It is essential to systematically analyze the mode of running city amateur match and propose development strategies. This study aimed to investigate the sustainable development strategies for city amateur matches in China through a hybrid model of SWOT and AHP using the Shanghai City Amateur Table Tennis Matches (ATTM) as a research case. Results showed that 20 factors of the SWOT analysis were included and the SWOT group weights are Strengths (5.1703), Opportunities (5.3732), Weaknesses (5.2882), and Threats (5.2386), respectively. The strategic vector coordinates (θ, ρ) are (72.42。, 0.6105). ATTM adopts the S-O development strategy and leverages its advantages and opportunities to promote further development. The findings indicate that ATTM with advanced organization operation mode has good internal strengths and external opportunities, which can enlighten the development of amateur table tennis at domestic and abroad. In the future, the S-O development strategy should be adopted.