bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying Factors Influencing Demolition Waste Generation from Stakeholders Perspective
Authors: Halim Hasmanie Abdul , Gisen Jacqueline Isabella , Aziz Edriyana A. , Shahid Khairul Anuar , Ghazali Norhaiza 
Published: January 2025

Abstract
Although construction and demolition waste (CDW) is relatively less hazardous when compared with other solid wastes, the large volumes occupied by bulky wastes in landfills pose a continual threat to human health and the environment. Determining factors contributing to the generation of CDW is, therefore, an important step toward developing effective and sustainable waste handling strategies. The objective of this study is to identify the CDW generation factors in the construction industry and the common disposal waste management practices on-site. The data collection involved a structured-questionnaire survey with 101 respondents from construction stakeholders within Kuantan District and later is analysed based on the descriptive statistic approach. The study result has revealed the top three important factors of CDW generation during construction works are workforce, material-handling, and management factors. While the common CDW management practice is waste disposal at the landfill. These findings will assist policymakers to improve existing guidelines to manage the CDW on construction sites.
Performance Evaluation of Porous Asphalt Mixture Reinforced by Lignin Fiber
Authors: Fazilah Fatin Fahira Nisha Mohd , Masri Khairil Azman , Al-Attab Ammar , Jaya Ramadhansyah Putra 
Published: January 2025

Abstract
This study aims to investigate the performance evaluation of porous asphalt (PA) mixture reinforced by lignin fiber. A kind of pavement called porous asphalt is made to let water percolate through its surface, minimising runoff and enhancing water management. Because of the unique combination of aggregates and asphalt used in its construction, water can percolate through and be absorbed into the ground below. However, there is always room for improvement in terms of enhancing its mechanical properties and overall performance. In this research, lignin fiber is incorporated into Porous Asphalt to evaluate their influence on key performance indicators such as rutting resistance, fatigue life, cracking, and mechanical strength. The study includes laboratory tests and performance assessments to compare the modified PA with conventional PA. To achieve the research objectives, various proportions of lignin fiber additives are introduced into the PA mix design (0%, 1%, 2%, 3%, 4%). The modified asphalt mixtures are then prepared and subjected to comprehensive laboratory tests, including Marshall stability, Indirect tensile strength, Binder drain down test, LA abrasion loss, Softening point and Penetration test. The performance evaluation also involves rutting and fatigue tests to assess the resistance of the modified mixtures to permanent deformation and fatigue cracking under simulated traffic loading conditions. The results obtained from the experimental investigations are analyzed and compared with the performance characteristics of conventional LF. In conclusion, the addition of 2-3% of LF additives enhanced the performance of PA in terms of rutting resistance, fatigue life, moisture susceptibility, and mechanical strength.
Design Concept and Stress Analysis of a Self-Activated Flood Barrier
Authors: Panior Khairul Nizad , Ithnin Zanidah , Jihin Rosmawati Mat , Nazri Azmarini Ahmad , Zakaria Supa’at Hj , Zulkipli Mohd Zulhairi 
Published: January 2025

Abstract
This paper presents the design concept and static stress analysis of a self-activated flood barrier, an innovative solution for flood defence in vulnerable areas such as urban centres, coastal regions, and riverbanks. The self-activated barrier is designed to respond autonomously to rising water levels without external power or human intervention, utilizing a buoyancy-driven mechanism that enables it to rise automatically as floodwaters approach critical levels. Designing a flood barrier involves a combination of scientific analysis, engineering design, construction, and community involvement. The design integrates a modular approach, allowing for scalability and adaptability to different geographic and infrastructural contexts. Static stress analysis was conducted on the barrier to evaluate its structural integrity under various flood conditions. The analysis focused on key components subjected to water pressure during deployment, ensuring the materials and structure could withstand the forces encountered during a flood event. Results from the analysis indicate that the barrier’s design is able to withstand the static load and the dynamic load that will occur under peak flood conditions. Furthermore, the material proposed for the inner barrier, which is Polyethylene terephthalate (PET) is lightweight yet durable and corrosion-resistant which will ensure long-term operational performance in harsh environments. Overall, the study demonstrates the effectiveness of the self-activated flood barrier in providing reliable, low-maintenance flood protection, with static stress analysis confirming its capability to endure extreme flood pressures.
Acquired drivers of C3 Glomerulopathy
Authors: Welsh Seth J , Zhang Yuzhou , Smith Richard J H 
Published: January 2025

Abstract
C3 glomerulopathy (C3G) is a group of heterogeneous ultra-rare kidney diseases characterized by dysregulated activation of the complement alternative pathway (AP) leading to excessive C3 cleavage. Diagnosis relies on kidney biopsy showing predominant C3 deposition in the glomerular basement membrane, with electron microscopy differentiating between dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). The main drivers of AP dysregulation in C3G are acquired rather than genetic and consist primarily of autoantibodies called nephritic factors (C3Nefs, C4Nefs, and C5Nefs) which bind to and stabilize complement convertases, causing complement over-activation. Current therapies are largely supportive, with limited efficacy from existing complement-targeting treatments like eculizumab. Challenges in studying C3G include variability in autoantibody detection and lack of standardized assays, which complicates clinical interpretation. Comprehensive assessment involving autoantibody panels, complement biomarkers, functional assays, and genetic testing provides a more complete understanding of disease dynamics; however, key knowledge gaps remain regarding Nef origins, mechanisms, and their pathogenic role. In this review we discuss acquired drives of C3G with an emphasis on C3Nefs and C5Nefs and suggest areas of interest that might benefit from future research.
BbGSD: Black-boned Sheep Genome SNP Database
Authors: He Chunjuan , Chen Lichang , Cao Juntao , Zhong Yuqing , Gao Zhendong , Deng Weidong , Zhang Jiajin 
Published: January 2025

Abstract
Lanping black-boned (LPBB) sheep are a unique and rare ruminant species, characterized by black pigmentation in the skin and internal organs. Thus far, LPBB are the only known animal with heritable melanin characteristics besides the black-boned chicken, and the only mammal known to contain a large amount of melanin in the body. LPBB have therefore attracted substantial research attention, due to their potential contribution to medicine. However, long periods of grazing freely and crossbreeding with Lanping normal sheep (LPN) have diluted LPBB breeding resources, posing a challenge to the protection of species. To ensure the effective conservation and management of LPBB genetic resources, the construction of a large-scale database of genotypic information is therefore very important. To achieve this, we established the first LPBB-specific SNP database, named Black-boned Sheep Genome SNP Database (BbGSD, http://202.203.179.115:3838/oarsnpdb) using sheep genotype data (100 LPBB and 50 LPN) across 46 894 242 SNP sites. In this database, we implemented four main function modules: (i) the “LD heatmap” module, which uses a heatmap to enable the interactive visualization of pairwise linkage disequilibrium (LD) measurements between SNPs; (ii) the “SNP distribution” module, which allows users to interactively visualize tabular genotype data as heat maps; (iii) the “Phylogenetics” module which enables phylogenetic analysis to explore the evolutionary history or genetic relationships of the LPBB sheep; and the “Diversity” module, which can be used to calculate and display the nucleotide diversity among sheep populations in user-specified genomic regions. BbGSD is essential for accelerating studies on the functional genomics and screening of molecular markers of molecular-assisted breeding in black-boned sheep.
Database URL: http://202.203.179.115:3838/oarsnpdb
The Welfare Effects of Supply and Demand Frictions in a Dynamic Pricing Game
Authors: Myśliwski Mateusz , Sanches Fabio Miessi , Junior Daniel Silva , Srisuma Sorawoot 
Published: January 2025

Abstract
We propose a dynamic oligopoly pricing model, in which consumers’ choices exhibit inertia and firms face costly price adjustments. The primitives of the model are estimated using scanner data from the UK butter and margarine industry. We evaluate the effects of frictions on price dynamics, profits and consumer welfare. We find that price adjustment costs are substantial and represent between 24-34% of net margins. Our model predicts that absence of these costs reduces persistence in prices, increases firms’ profits but has little effect on consumer surplus. The effects of consumer inertia on prices are much more pronounced than when firms cannot adjust prices freely.
An integrated ecotoxicological study reliability framework for use in toxicity value development
Authors: Kennedy Stephanie B , Heintz Melissa M , Klaren William D , Wikoff Daniele S , Haws Laurie C , Fitch Seneca E 
Published: January 2025

Abstract
A key component of ecological risk assessments is to develop evidence-based benchmarks to assess potential hazards to various receptors. To ensure that toxicity value development is performed using the best available science, the reliability (or inherent scientific quality) of these studies must be considered. The degree of reliability can be evaluated via critical appraisal tools (CATs), although application of such methods assessing ecotoxicological literature for toxicity value development is not well established compared with human health assessments. A review of existing CATs revealed that there is currently no approach that considers the full range of biases that should be considered for appraisal of internal validity in ecotoxicological studies. Recognizing the need for a comprehensive ecotoxicity study assessment framework that addresses RoB for the interpretation of study reliability, we propose the ecotoxicological study reliability (EcoSR) framework. This framework builds on the classic RoB assessment approach, frequently applied in human health assessments. The EcoSR framewok adds reliability and key criteria specific to ecotoxicity studies from existing appraisal methods, emphasizing those used by regulatory bodies. Additionally, the framework recommends a priori customization based on assessment goals. The EcoSR framework is composed of two tiers: an optional preliminary screening (Tier 1) and a full reliability assessment (Tier 2). The framework outlines a systematic approach for conducting ecotoxicity study appraisals that enhances transparency and consistency in determining study reliability. The EcoSR framework provides flexibility and can be refined and applied to a variety of chemical classes. This framework represents a significant step towards improving the transparency and reproducibility of ecotoxicological study appraisals; ultimately, contributing to more informed and reliable toxicity value development within the ecological sciences.
Tricuspid regurgitation and outcomes in mitral valve transcatheter edge-to-edge repair
Authors: Matsumoto Shingo , Ohno Yohei , Noda Satoshi , Miyamoto Junichi , Kamioka Norihiko , Murakami Tsutomu , Ikari Yuji , Kubo Shunsuke , Izumi Yuki , Saji Mike , Yamamoto Masanori , Asami Masahiko , Enta Yusuke , Shirai Shinichi , Izumo Masaki , Mizuno Shingo , Watanabe Yusuke , Amaki Makoto , Kodama Kazuhisa , Yamaguchi Junichi , Naganuma Toru , Bota Hiroki , Yamawaki Masahiro , Ueno Hiroshi , Mizutani Kazuki , Hachinohe Daisuke , Otsuka Toshiaki , Hayashida Kentaro 
Published: January 2025

Abstract

Background and Aims
The association between periprocedural change in tricuspid regurgitation (TR) and outcomes in patients undergoing mitral transcatheter edge-to-edge repair (M-TEER) is unclear. This study aimed to examine the prognostic value of TR before and after M-TEER.

Methods
Patients in the OCEAN-Mitral registry were divided into four groups according to baseline and post-procedure echocardiographic assessments: no TR/no TR (no TR), no TR/significant TR (new-onset TR), significant TR/no TR (normalized TR), and significant TR/significant TR (residual TR) (all represents before/after M-TEER). Tricuspid regurgitation ≥ moderate was defined as significant. The primary outcome was cardiovascular death or heart failure hospitalization. Tricuspid regurgitation pressure gradient was also evaluated.

Results
The numbers of patients in each group were 2103 (no TR), 201 (new-onset TR), 504 (normalized TR), and 858 (residual TR). Baseline assessment for TR and TR pressure gradient was not associated with outcomes after M-TEER. In contrast, patients with new-onset TR had the highest adjusted risk for the primary outcome, followed by those with residual TR [compared with no TR as a reference, hazard ratio 1.83 (95% confidence interval: 1.39–2.40) for new-onset TR, 1.45 (1.23–1.72) for residual TR, and 0.82 (0.65–1.04) for normalized TR]. Similarly, from baseline to post-procedure, TR pressure gradient changes were associated with subsequent outcomes after M-TEER. New-onset and residual TR incidence was commonly associated with dilated tricuspid annulus diameter and atrial fibrillation.

Conclusions
Post-procedural TR, but not baseline TR, was associated with outcomes after M-TEER. Careful TR assessment after the procedure would provide an optimal management for concomitant significant TR in patients undergoing M-TEER.
Isolation by environment is more important than isolation by distance along a tropical gradient in direct developing frogs
Authors: Percino-Daniel Ruth , Jones Kara S , Maigret Thomas A , Weisrock David W , Piñero Daniel 
Published: January 2025

Abstract
Abiotic factors are important for defining population structure and limiting gene flow, especially in ectotherm species. In amphibians, abiotic factors like temperature and precipitation can facilitate or restrict gene flow. The challenge is identifying if these factors can lead to a pattern of isolation by environment. Our study aims to quantify the extent to which divergence is driven by abiotic factors such as temperature, precipitation and elevation. To do so, we used a direct-developing frog species, Craugastor loki that occurs along a steep elevation gradient. Using restriction-site associated DNA sequencing (RADseq) from individuals collected from 100 m to 2250 m of elevation across 13 localities at Sierra Madre de Chiapas in southern Mexico, we described population structure using a variety of model-based clustering and landscape genomics approaches. We found that populations sampled at higher elevation probably correspond to an undescribed new species of Craugastor, and that populations from Craugastor loki between 120 m and 1500 m are clustered in two different genetic groups: a Pacific slope group and a Central Depression slope group. We found signatures of isolation by environment more important than isolation by distance in contributing to genetic divergence in this group of frogs at a fine scale. The environmental variables such as: mean temperature of wettest and warmest quarter, annual mean temperature, and seasonality in temperature and precipitation play an important role on population differentiation. Our results underscore the importance of abiotic factors as drivers of genetic differentiation and highlight the use of different approaches to illuminate fine scale population divergence given the complexity of disentangling the contribution of both patterns of isolation.
‘The movie theatres are little bits of things’: Poetry and Cinema in Montale and Stevens
Authors: Manara Matilde 
Published: January 2025

Abstract
Theodor Adorno, Siegfried Kracauer, José Ortega y Gasset: these are just a few of the thinkers who, at the turn of the twentieth century, expressed critical views on cinema and the way it affects its audience. Poets of the same period were equally sceptical about the new media and, above all, about the model of mass liberal education that was held responsible for their success. Caught between fascination and revulsion, they nevertheless seemed unable to avoid adding to their texts some elements taken from the collective and supposedly hypnotizing experience of watching a movie, often with the aim of contrasting it with the solitary and controlled experience of reading a poem. This article aims to reflect on these intermediary fragments in the work of two of the most representative authors of European and Anglo-American Modernism: Eugenio Montale and Wallace Stevens. The analysis of ‘Forse un mattino andando in un’aria di vetro’ and ‘The Ordinary Women’, as well as the reading of their notes on cinema, will allow us to show that the relationship of Modernist poetry (a supposedly conservative and elitist movement) with mass culture and its media is much more ambivalent than is usually thought.
Spatially explicit estimation of recent migration rates in plants using genotypic data
Authors: Chybicki Igor J , Robledo-Arnuncio Juan J 
Published: January 2025

Abstract
We present a new hierarchical Bayesian method using multilocus genotypes to estimate recent seed and pollen migration rates in a spatially explicit framework that incorporates distance effects separately for each type of dispersal. The method additionally estimates population allelic frequencies, population divergence values, individual inbreeding coefficients, individual maternal and paternal ancestries, and allelic dropout rates. We conduct a numerical simulation analysis that indicates that the method can provide reliable estimates of seed and pollen migration rates and allow accurate inference of spatial effects on migration, at affordable sample sizes (25–50 individuals/population) when population genetic divergence is not low (FST≥0.05), or by increasing sampling (to at least 100 individuals/population) under weaker levels of divergence (FST=0.025). Simulations also show that the accuracy provided by assays with about one thousand unlinked polymorphic SNP loci may approach, for a given sample size, the theoretical maximum achievable under categorical origin discrimination. We apply our method to Taxus baccata data, revealing low but significant seed and pollen migration among nearby population remnants during the last generation, with a negative effect of interpopulation distance on migration that was detectable for pollen but not for seeds.
Activated SKN-1 alters the aging trajectories of long-lived C. elegans mutants
Authors: Turner Chris D , Curran Sean P 
Published: January 2025

Abstract
In the presence of stressful environments, the SKN-1 cytoprotective transcription factor is activated to induce the expression of gene targets that can restore homeostasis. However, chronic activation of SKN-1 results in diminished health and a reduction of lifespan. Here we demonstrate the necessity of modulating SKN-1 activity to maintain the longevity-promoting effects associated with genetic mutations that impair daf-2/insulin receptor signaling, the eat-2 model of dietary restriction, and glp-1-dependent loss of germ cell proliferation. A hallmark of animals with constitutive SKN-1 activation is the age-dependent loss of somatic lipids and this phenotype is linked to a general reduction in survival in animals harboring the skn-1gf allele. Surprisingly, daf-2lf; skn-1gf double mutant animals do not redistribute somatic lipids, which suggests the insulin signaling pathway functions downstream of SKN-1 in the maintenance of lipid distribution. As expected, the eat-2lf allele, which independently activates SKN-1, continues to display somatic lipid depletion in older ages with and without the skn-1gf activating mutation. In contrast, the presence of the skn-1gf allele does not lead to somatic lipid redistribution in glp-1lf animals that lack a proliferating germline. Taken together, these studies support a genetic model where SKN-1 activity is an important regulator of lipid mobilization in response to nutrient availability that fuels the developing germline by engaging the daf-2/insulin receptor pathway.
Potential risk of cross-resistance to voriconazole in HIV/AIDS patients with Talaromyces marneffei infection and the mechanisms of the cross-resistance
Authors: Zheng Yan-Qing , Li Qiang-Guo , Latge Jean-Paul , Tang Xi-Ke , Najwa Al-Odaini , Pan Kai-Su , Yang Shi-Xiong , Cao Cun-Wei 
Published: January 2025

Abstract

Background
The use of fluconazole for long-term oral candidiasis treatment in HIV/AIDS patients can potentially affect the clearance rate and antifungal efficacy of voriconazole against Talaromyces marneffei infection. We isolated two T. marneffei strains that were both resistant to fluconazole and voriconazole. To investigate the mechanism underlying the induction of the cross-resistance in T. marneffei.

Methods
Fluconazole-resistant strains were induced in vitro. The target enzyme 14-α sterol demethylase Cyp51B was sequenced, and drug efflux pump expression was determined by RT–qPCR in all strains.

Results
The sensitivity of fluconazole-induced resistant strains to fluconazole was greater than 128 mg/L, and this resistance was stably inherited after fluconazole pressure was removed. MICs of voriconazole for resistant strains were 4∼16 times greater than FRR (0.25–1 versus 0.06 mg/L). Two mutation hotspots in Cyp51B were detected: G441D and G441V. The AtrF, Mdr1 and Pmfcz genes were significantly overexpressed in the vast majority of the fluconazole-resistant strains (P &lt; 0.05).

Conclusions
The growth of T. marneffei in the presence of fluconazole could induce voriconazole resistance in vitro. The main cause of this cross-resistance in T. marneffei appears to be related to a mutation in Cyp51B at G441 and overexpression of the efflux pumps AtrF, Mdr1 and Pmfcz.