bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetric Dipole Trends in Geodynamo Models and the Paleomagnetic Field
Authors: Buffett B. A. 
Published: December 2023

AbstractTemporal trends in the paleomagnetic dipole moment exhibit the property of positive skewness. On average, positive trends are larger and occur less frequently than negative trends over timescales of several tens of kyr. We explore the origin of this property using numerical geodynamo models. A suite of models reveals that skewness arises for a restricted set of boundary conditions. Models driven by heat flow at the top and bottom boundaries exhibit very little skewness, whereas models driven solely by heat flow on the lower boundary produce significant positive skewness. Further increases in skewness occur in the presence of thermal stratification at the top of the core. The level of skewness in the geodynamo models is correlated with estimates of upwelling near the core‐mantle boundary. Sustained upwelling is expected to increase magnetic‐flux expulsion, contributing to higher levels of skewness. Similar behavior is recovered from stochastic models in which the dipole is generated by a random series of cyclonic convection events. Skewness in the stochastic models is quantitatively similar to estimates from the geodynamo models when the average recurrence time of the convection events is 100 years. Extending the stochastic models to the paleomagnetic field implies a longer recurrence time of 1,000 years or more. We interpret this recurrence time in terms of the timing of flux‐expulsion events rather than individual convective events. Abrupt increases in the dipole moment from flux expulsion can produce skewed trends on timescales of tens of kyr.
Thermochemical Structure and Melting Distribution of the Upper Mantle Beneath Intraplate Volcanic Areas in Eastern South China Block
Authors: Zhang Anqi , Guo Zhen , Dai Hongkun , Yang Yingjie 
Published: December 2023

AbstractThe Eastern South China Block (SCB) has experienced complex Mesozoic‐Cenozoic tectonism and intraplate volcanism. However, due to a lack of exhaustive exploration of the upper mantle's thermochemical structure, it is difficult to determine the extent of the lithospheric modification and the mechanisms by which the volcanism generate. Here, we jointly invert Rayleigh wave dispersion, surface heat flow, geoid height, and elevation data to provide a comprehensive thermal and compositional structure of the upper mantle beneath eastern SCB and infer regions of partial melting. Our model reveals widespread lithospheric thinning in the eastern SCB and large variations of lithospheric composition with a more fertile eastern Lower Yangtze lithosphere than the lithosphere elsewhere, suggesting the lithosphere of the eastern Lower Yangtze is more severely modified than the rest of the SCB. Moreover, two high‐temperature anomalies are revealed: one beneath the eastern Lower Yangtze and the other beneath the Pearl River Delta region, associated with the Pacific plate subduction and Hainan plume, respectively. The high‐degree partial melting (∼6%) in the asthenosphere beneath the Lower Yangtze is responsible for the strong ongoing lithospheric modification and the young intraplate volcanism in the Nvshan and Subei areas. Small‐scale upper mantle convections triggered by the large mantle upwellings created a low value of ∼3% melts, possibly responsible for the intraplate volcanism in the coastal CB and less severe lithospheric modification. We demonstrate that the lithospheric thickness and its thermochemical state are the key factors that influence the composition and evolution of intraplate volcanism in the eastern SCB.
Long‐Term Landscape Evolution in Response to Climate Change, Ecosystem Dynamics, and Fire in a Basaltic Catchment on the Colorado Plateau
Authors: Staley Spencer E. , Fawcett Peter J. , Jiménez‐Moreno Gonzalo , Anderson R. Scott , Markgraf Vera , Brown Erik T. 
Published: December 2023

AbstractPredicting responses of semi‐arid to montane landscapes in southwestern North America to ongoing anthropogenic changes requires understanding of past interplay among geomorphic, ecologic, and climatic factors. This study utilizes modern weathering and sediment transport processes to inform the interpretation of a 250‐kyr lacustrine sediment record of paleoecology, hydrology, and erosion from a small, closed basin, basaltic catchment on the southwestern edge of the Colorado Plateau. Geochemical and mineralogical analyses of bedrock, colluvium, and lake sediments indicate that clastic sediments in the basin are a mixture of local physical weathering products (albite and ilmenite) and eolian dust (quartz, illite, and zircon). Dust fractions increase during glacial periods coincident with lower overall sedimentation rates, suggesting this pattern results from decreased local erosion rates and not increased dust deposition. Titanium counts from X‐ray fluorescence core scanning, a proxy for ilmenite content, traces past local erosion rates. The highest erosion rates, inferred from the highest Ti counts, follow climatic transitions toward interglacial conditions (Marine Isotope Stage 5e, 3a, and the Holocene), periods characterized by vegetation changeover (observed in the core's palynology), higher temperatures (piñon‐juniper‐oak pollen abundance), lower effective precipitation (shallow lake facies), and increased wildfire activity (microscopic charcoal particle counts and sizes). While brief inferred episodes of erosion occur following abrupt transitions to cooler and wetter conditions, indicated by the abundance of subalpine tree (spruce and fir) pollen and deeper lake facies, landscapes appear more stable during glacial periods. This long‐term perspective suggests that aridification and resulting vegetation succession and increased wildfires will increase erosion rates in similar settings regionwide.
Analysis of Two Selected Solar Events in 2011 and 2015 With Mars Express Radio Occultation Data
Authors: Krishnan Ananya , Karatekin Ozgur , Verkercke Sebastien , Henry Gregoire , Sánchez‐Cano Beatriz , Witasse Olivier 
Published: December 2023

AbstractThe temporal behavior of the Martian ionosphere is highly variable due to various dynamic processes including space weather events. Here, we study the effect of solar flares and coronal mass ejections (CMEs) on the Martian ionosphere for two selected solar events in 2011 and 2015, using the publicly available Mars EXpress (MEX) radio occultation (RO) data (MaRS). We developed a data processing software that converts the calibrated Radio Occultation (RO) Doppler data to scientifically valuable atmospheric profiles. Using this software and previously unexplored MaRS observations, the variations in ionospheric parameters (electron density profiles and total electron content (TEC)) are calculated in order to evaluate the ionospheric changes due to solar flares and CMEs. The RO measurements mostly available 1–4 days apart from the peak events, showed no evident change in the TEC nor in the shape of electron density profiles except for a possible gradual decrease in altitude of M2 (main layer) peak density following the arrival of CMEs. To better quantify the effect of solar events on electron density profiles, RO observations near the time of arrival of solar flares and CMEs are crucial. This can be achieved by frequent RO measurements by various Mars orbiters including spacecraft‐to‐spacecraft measurements assisted by multi‐instrument monitoring of the ionosphere.
The emergence of obesity in type 1 diabetes
Authors: Kueh Martin T. W. , Chew Nicholas W. S. , Al-Ozairi Ebaa , le Roux Carel W. 
Published: December 2023

AbstractObesity, a chronic low-grade inflammatory disease represented by multifactorial metabolic dysfunctions, is a significant global health threat for adults and children. The once-held belief that type 1 diabetes is a disease of people who are lean no longer holds. The mounting epidemiological data now establishes the connection between type 1 diabetes and the subsequent development of obesity, or vice versa. Beyond the consequences of the influx of an obesogenic environment, type 1 diabetes-specific biopsychosocial burden further exacerbates obesity. In the course of obesity management discussions, recurring challenges surfaced. The interplay between weight gain and escalating insulin dependence creates a vicious cycle from which patients struggle to break free. In the absence of weight management guidelines and regulatory approval for this population, healthcare professionals must navigate the delicate balance between benefits and risks. The gravity of this circumstance highlights the importance of bringing these topics to the forefront. In this Review, we discuss the changing trends and the biopsychosocial aspects of the intersection between type 1 diabetes and obesity. We highlight the evidence supporting the therapeutic means (i.e., exercise therapy, nutritional therapy, adjunct pharmacotherapy, and bariatric surgery) and directions for establishing a more robust and safer evidence-based approach.
Cotton microbiome profiling and Cotton Leaf Curl Disease (CLCuD) suppression through microbial consortia associated with Gossypium arboreum
Authors: Aqueel Rhea , Badar Ayesha , Roy Nazish , Mushtaq Qandeel , Ali Aimen Fatima , Bashir Aftab , Ijaz Umer Zeeshan , Malik Kauser Abdulla 
Published: December 2023

AbstractThe failure of breeding strategies has caused scientists to shift to other means where the new approach involves exploring the microbiome to modulate plant defense mechanisms against Cotton Leaf Curl Disease (CLCuD). The cotton microbiome of CLCuD-resistant varieties may harbor a multitude of bacterial genera that significantly contribute to disease resistance and provide information on metabolic pathways that differ between the susceptible and resistant varieties. The current study explores the microbiome of CLCuD-susceptible Gossypium hirsutum and CLCuD-resistant Gossypium arboreum using 16 S rRNA gene amplification for the leaf endophyte, leaf epiphyte, rhizosphere, and root endophyte of the two cotton species. This revealed that Pseudomonas inhabited the rhizosphere while Bacillus was predominantly found in the phyllosphere of CLCuV-resistant G. arboreum. Using salicylic acid-producing Serratia spp. and Fictibacillus spp. isolated from CLCuD-resistant G. arboreum, and guided by our analyses, we have successfully suppressed CLCuD in the susceptible G. hirsutum through pot assays. The applied strains exhibited less than 10% CLCuD incidence as compared to control group where it was 40% at 40 days post viral inoculation. Through detailed analytics, we have successfully demonstrated that the applied microbes serve as a biocontrol agent to suppress viral disease in Cotton.
Structures, functions and adaptations of the human LINE-1 ORF2 protein
Authors: Baldwin Eric T. , van Eeuwen Trevor , Hoyos David , Zalevsky Arthur , Tchesnokov Egor P. , Sánchez Roberto , Miller Bryant D. , Di Stefano Luciano H. , Ruiz Francesc Xavier , Hancock Matthew , Işik Esin , Mendez-Dorantes Carlos , Walpole Thomas , Nichols Charles , Wan Paul , Riento Kirsi , Halls-Kass Rowan , Augustin Martin , Lammens Alfred , Jestel Anja , Upla Paula , Xibinaku Kera , Congreve Samantha , Hennink Maximiliaan , Rogala Kacper B. , Schneider Anna M. , Fairman Jennifer E. , Christensen Shawn M. , Desrosiers Brian , Bisacchi Gregory S. , Saunders Oliver L. , Hafeez Nafeeza , Miao Wenyan , Kapeller Rosana , Zaller Dennis M. , Sali Andrej , Weichenrieder Oliver , Burns Kathleen H. , Götte Matthias , Rout Michael P. , Arnold Eddy , Greenbaum Benjamin D. , Romero Donna L. , LaCava John , Taylor Martin S. 
Published: December 2023

AbstractThe LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written around one-third of the human genome through a ‘copy and paste’ mechanism catalysed by its multifunctional enzyme, open reading frame 2 protein (ORF2p)1. ORF2p reverse transcriptase (RT) and endonuclease activities have been implicated in the pathophysiology of cancer2,3, autoimmunity4,5 and ageing6,7, making ORF2p a potential therapeutic target. However, a lack of structural and mechanistic knowledge has hampered efforts to rationally exploit it. We report structures of the human ORF2p ‘core’ (residues 238–1061, including the RT domain) by X-ray crystallography and cryo-electron microscopy in several conformational states. Our analyses identified two previously undescribed folded domains, extensive contacts to RNA templates and associated adaptations that contribute to unique aspects of the L1 replication cycle. Computed integrative structural models of full-length ORF2p show a dynamic closed-ring conformation that appears to open during retrotransposition. We characterize ORF2p RT inhibition and reveal its underlying structural basis. Imaging and biochemistry show that non-canonical cytosolic ORF2p RT activity can produce RNA:DNA hybrids, activating innate immune signalling through cGAS/STING and resulting in interferon production6–8. In contrast to retroviral RTs, L1 RT is efficiently primed by short RNAs and hairpins, which probably explains cytosolic priming. Other biochemical activities including processivity, DNA-directed polymerization, non-templated base addition and template switching together allow us to propose a revised L1 insertion model. Finally, our evolutionary analysis demonstrates structural conservation between ORF2p and other RNA- and DNA-dependent polymerases. We therefore provide key mechanistic insights into L1 polymerization and insertion, shed light on the evolutionary history of L1 and enable rational drug development targeting L1.
Torrefaction of kraft pulp mills sludges
Authors: Moreira Miquelino Eleto Torres Caio , Oliveira Carneiro Angélica de Cássia , Cunha Rodrigues Bruna Virgínia , Foresti Salgado Bravo Marina , Mudadu Silva Claudio 
Published: December 2023

AbstractTorrefaction emerges as an industrial process that increases the energy content of conventional biomass. Primary and secondary sludge are the main solid residues generated in the Effluent Treatment Plants of bleached kraft pulp mills, and can be considered as biomass. Typically, these wastes are sent to industrial landfills. The present study aimed to evaluate the technical feasibility of transforming the primary sludge (PS), secondary sludge (SS) and mixed sludges (MIX) into torrefied biomass for energy generation. Three temperatures (260, 290 and 320 °C) and three residence times (20, 40 and 60′) were used in the sludge torrefaction process. Increasing the torrefaction temperature and residence time of the sludges produced several benefits on their physical and chemical properties. They promoted an increase in the heating value, due to the elimination of less energetic compounds and the concentration of the fixed carbon content; caused a reduction of moisture, with a consequent increase in the lower heating value of the sludges; and led to a high energy yield and an increased energy density, important parameters in sludges energy generation. The treatment at 320 °C for 60′ obtained increases of 76%, 27% and 41% over the reference, for PS, SS and MIX, respectively.
Fetching felines: a survey of cat owners on the diversity of cat (Felis catus) fetching behaviour
Authors: Forman Jemma , Renner Elizabeth , Leavens David A. 
Published: December 2023

AbstractDomesticated animals are famous for the ease with which they can accommodate to diverse human environments and roles, but less well-studied is the ease with which domestic animals can manipulate their human caregivers to their own ends. For example, domestic animals may start and end their play behaviour with humans at times of their choice. Here we present the results of a survey of 924 cat owners who report fetching behaviour in 1154 cats. The overwhelming majority (94.4%) of these owners report that fetching emerged in the absence of explicit training. Fetching was primarily first noticed when the cats were less than one year old (n = 701) or 1–7 years old (n = 415). Cats initiated and terminated fetching bouts more often than did their owners. Thus, cats who fetch demonstrate independent and co-ordinated agency in the onset and maintenance of fetching behaviour with their human partners. Additional findings highlight the diversity of objects fetched and the diversity in household demographics. Our thematic analysis reveals owners’ perspectives on (a) the process of a fetching session, (b) the initial acquisition of fetching, and (c) the circumstantial factors that influence fetching patterns. In summary, cats who fetch largely determine when they engage in fetching sessions and actively influence the play behaviour of their owners.
A citizen science model turns anecdotes into evidence by revealing similar characteristics among Gifted Word Learner dogs
Authors: Dror Shany , Miklósi Ádám , Sommese Andrea , Fugazza Claudia 
Published: December 2023

AbstractDogs that have a vocabulary of object labels (Gifted Word Learner dogs—GWL dogs) have great potential as a comparative model for studying a variety of cognitive mechanisms. However, only a handful of studies, with a small sample size of 1 or 2 dogs, have examined this phenomenon. GWL dogs appear to share many of the same distinctive characteristics, but due to their rarity, it is not clear if these similarities are only anecdotal or indeed reflect characteristics that are similar in these rare individuals. Here we present the first study conducted on a relatively large sample of 41 GWL dogs that were recruited and tested using a citizen science model. After testing the dogs' receptive vocabulary of toy names, we asked the owners to complete a questionnaire about their and their dog’s life experiences. Our findings highlight several characteristics that are shared among most GWL dogs, such as their learning speed, their large vocabulary, and that they learned the names of the toys spontaneously, without the explicit intent of their owners. Our findings validate previous anecdotal evidence on common characteristics of GWL dogs and supply additional support to the hypothesis that these dogs represent a unique group of dogs.
Minimally invasive technique combined with external fixator in the treatment of pediatric flexion-type humeral supracondylar fractures
Authors: Zhu ChengMing , Feng QiYuan , Ou ZiXuan , Zhong HaoBo , Tang Xin 
Published: December 2023

AbstractFlexion-type pediatric humeral supracondylar fractures are rare, and the reduction technique remains contradictory. A minimally invasive technique using percutaneous leverage reduction combined with an external fixator was described to achieve satisfactory reduction and avoid the open reduction in this study. The operation and clinical results of patients treated with this technique were retrospectively compared with traditional closed reduction. From January 2013 to January 2018, children diagnosed with displaced flexion-type humeral supracondylar fractures were included in this study. Patients were treated with closed reduction (Group A) or minimally invasive reduction technique (Group B). The external fixator fixation was then applied. The demographic information, as well as the clinical and functional results of the operation, were retrospectively reviewed and evaluated. There were twenty-two patients, ten in Group A and twelve in Group B. The mean duration of the operation in Group A was more prolonged than Group B (59 min versus 46 min, p < 0.001). No infection, nonunion, myositis ossificans, neurovascular injury or other complications related to the operation were observed by the time the fractures healed. During an average 36 months follow-up time, almost all children achieved good to excellent results except for one fair in Group A according to the MEPS and the Flynn criteria. This study introduced a safe and efficient minimally invasive technique for displaced flexion-type supracondylar humerus fractures. With the assistance of mosquito forceps, this leverage technique might achieve similar satisfactory clinical outcomes as traditional closed reduction but with a shorter surgical duration.
A pilot study on non-invasive in situ detection of phytochemicals and plant endogenous status using fiber optic infrared spectroscopy
Authors: Zhang Shuyan , Jie Randall Ang , Teo Mark Ju Teng , Xinhui Valerie Teo , Koh Sally Shuxian , Tan Javier Jingheng , Urano Daisuke , Dinish U. S. , Olivo Malini 
Published: December 2023

AbstractTraditional methods for assessing plant health often lack the necessary attributes for continuous and non-destructive monitoring. In this pilot study, we present a novel technique utilizing a customized fiber optic probe based on attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) with a contact force control unit for non-invasive and continuous plant health monitoring. We also developed a normalized difference mid-infrared reflectance index through statistical analysis of spectral features, enabling differentiation of drought and age conditions in plants. Our research aims to characterize phytochemicals and plant endogenous status optically, addressing the need for improved analytical measurement methods for in situ plant health assessment. The probe configuration was optimized with a triple-loop tip and a 3 N contact force, allowing sensitive measurements while minimizing leaf damage. By combining polycrystalline and chalcogenide fiber probes, a comprehensive wavenumber range analysis (4000–900 cm−1) was achieved. Results revealed significant variations in phytochemical composition among plant species, for example, red spinach with the highest polyphenolic content and green kale with the highest lignin content. Petioles displayed higher lignin and cellulose absorbance values compared to veins. The technique effectively monitored drought stress on potted green bok choy plants in situ, facilitating the quantification of changes in water content, antioxidant activity, lignin, and cellulose levels. This research represents the first demonstration of the potential of fiber optic ATR-FTIR probes for non-invasive and rapid plant health measurements, providing insights into plant health and advancements in quantitative monitoring for indoor farming practices, bioanalytical chemistry, and environmental sciences.
A dose-escalation study of HP501, a highly selective URAT1 inhibitor, in male Chinese patients with hyperuricemia
Authors: Ding Ruilin , Deng Xuehong , Chen Longxia , Zhen Yang , Li Xinghai , Xiong Tengqiong , Zhang Yuanhua , Chen Hong , Hu Xiaojing , Li Yun , Zhou Yi , Jiang Feng , Peng Qing , Wang Xiaojie 
Published: December 2023

AbstractHP501 is a highly selective renal urate transporter 1 (URAT1) inhibitor used for treating hyperuricemia. This study aimed to evaluate the tolerability, pharmacokinetics, and pharmacodynamics of HP501 in male Chinese patients. Patients with hyperuricemia were sequentially assigned to receive oral doses of HP501 (30, 50, 60, 90, and 120 mg) as a single dose on Day 1 and as once-daily doses from Days 4 to 13. Safety, pharmacokinetic, and pharmacodynamic data were collected. Multiple oral doses of HP501 were well-tolerated in all the cohorts. The most common adverse events (≥ 10% of patients) of any grade regardless of drug relationship were gout flare (14 patients, 25.93%), diarrhea (12 patients, 22.22%), elevated ALT (8 patients, 14.81%), hypertriglyceridemia (7 patients, 12.96%), dry mouth (7 patients, 12.96%) and oral ulcer (7 patients, 12.96%). All adverse events were mild or moderate. The Cmax and exposure (AUC) of HP501 was approximately dose-proportional between 30 and 120 mg. A dose-dependent serum uric acid (UA)-lowering effect was observed in the dose range of 30 to 60 mg and the serum UA lowering effect was similar between 90 and 120 mg on day 13, indicating that the maximal serum UA lowering effect of HP501 was achieved at 90 mg in the patients with hyperuricemia. In conclusion, the tolerability, pharmacokinetics, and pharmacodynamics supported 90 mg HP501 for subsequent clinical studies of this highly selective URAT1 inhibitor.Clinical Trial registration: No. CTR20212259 (http://www.chinadrugtrials.org.cn/) was registered in September 2021, and No. CTR20222257 was registered in September 2022.