bluuebunny/crossref_metadata_2025_split huggingface dataset:
IgG4‐related pancreatobiliary diseases could be associated with onset of pancreatobiliary cancer: A multicenter cohort study
Authors: Kurita Yusuke , Kubota Kensuke , Fujita Yuji , Tsujino Seitaro , Sekino Yusuke , Kasuga Noriki , Iwasaki Akito , Iwase Mai , Izuka Takeshi , Kagawa Koichi , Tanida Emiko , Yagi Shin , Hasegawa Sho , Sato Takamitsu , Hosono Kunihiro , Kobayashi Noritoshi , Ichikawa Yasushi , Nakajima Atsushi , Endo Itaru 
Published: December 2023

AbstractBackgroundThe risk and prognosis of pancreatobiliary cancer and in patients with autoimmune pancreatitis (AIP) and IgG4‐related sclerosing cholangitis (IgG4‐SC) remain unclear. Therefore, we retrospectively investigated the risk of pancreatobiliary cancer and prognosis in patients with AIP and IgG4‐SC.MethodsPatients with AIP and IgG4‐SC at seven centers between 1998 and 2022 were investigated. The following data were evaluated: (1) the number of cancers diagnosed and standardized incidence ratio (SIR) for pancreatobiliary and other cancers during the observational period and (2) prognosis after diagnosis of AIP and IgG4‐SC using standardized mortality ratio (SMR).ResultsThis study included 201 patients with AIP and IgG4‐SC. The mean follow‐up period was 5.7 years. Seven cases of pancreatic cancer were diagnosed, and the SIR was 8.11 (95% confidence interval [CI]: 7.29–9.13). Three cases of bile duct cancer were diagnosed, and the SIR was 6.89 (95% CI: 6.20–7.75). The SMR after the diagnosis of AIP and IgG4‐SC in cases that developed pancreatobiliary cancer were 4.03 (95% CI: 2.83–6.99).ConclusionsPatients with autoimmune pancreatitis and IgG4‐SC were associated with a high risk of pancreatic and bile duct cancer. Patients with AIP and IgG4‐SC have a worse prognosis when they develop pancreatobiliary cancer.
Breaking down relationship barriers to increase PrEP uptake and adherence among adolescent girls and young women in Kenya: safety and preliminary effectiveness results from a pilot cluster‐randomized trial
Authors: Roberts Sarah T. , Hartmann Miriam , Minnis Alexandra M. , Otticha Sophie Odek , Browne Erica N. , Montgomery Elizabeth T. , Agot Kawango 
Published: December 2023

AbstractIntroductionOral pre‐exposure prophylaxis (PrEP) has the potential to reduce HIV acquisition among adolescent girls and young women (AGYW) in sub‐Saharan Africa, a priority population for epidemic control. However, intimate partner violence (IPV) and low relationship power can create significant challenges to PrEP use. The Tu'Washindi intervention aimed to increase PrEP use by addressing relationship‐ and violence‐related barriers among AGYW enrolled in the DREAMS Initiative in Siaya County, Kenya.MethodsOur multi‐level, community‐based intervention was piloted in a cluster‐randomized controlled trial conducted at six DREAMS sites from April to December 2019 (NCT03938818). Three intervention components were delivered over 6 months: an eight‐session empowerment‐based support club, community sensitization targeted towards male partners and a couples’ PrEP education event. Participants were ages 17–24, HIV negative and either eligible for, or already taking, PrEP. Over 6 months of follow‐up, we assessed IPV (months 3 and 6) and PrEP uptake and continuation (month 6) through interviewer‐administered questionnaires; PrEP adherence was assessed with Wisepill electronic monitoring devices. These outcomes were compared using adjusted Poisson and negative binomial regression models.ResultsWe enrolled 103 AGYW with median age of 22 years (IQR 20–23); one‐third were currently taking PrEP and 45% reported IPV in the past 3 months. Retention was 97% at month 6. Compared to the control arm, intervention arm participants were more likely to initiate PrEP, if not already using it at enrolment (52% vs. 24%, aRR 2.28, 95% CI 1.19–4.38, p = 0.01), and those taking PrEP had more days with device openings (25% of days vs. 13%, aRR 1.94, 95% CI 1.16–3.25, p = 0.01). Twenty percent of participants reported IPV during follow‐up. There were trends towards fewer IPV events (aIRR 0.66, 95% CI 0.27–1.62, p = 0.37) and fewer events resulting in injury (aIRR 0.21, 95% CI 0.04–1.02, p = 0.05) in the intervention versus control arm.ConclusionsTu'Washindi shows promise in promoting PrEP uptake and adherence among AGYW without concomitant increases in IPV; however, adherence was still suboptimal. Further research is needed to determine whether these gains translate to increases in the proportion of AGYW with protective levels of PrEP adherence and to evaluate the potential for the intervention to reduce IPV risk.
Five‐year EuroQol 5‐Dimension Outcomes After Endoscopic Sinus Surgery
Authors: Tashman Katherine , Adams Dara , Vickery Thad W. , Holbrook Eric H. , Gray Stacey T. , Bleier Benjamin S. , Scangas George , Metson Ralph 
Published: December 2023

ObjectiveThe EuroQol 5‐Dimension (EQ‐5D) is a general health survey that is quick to administer, widely used, and directly convertible to health utility values (HUV). We aim to describe the five‐year EQ‐5D outcomes among patients who undergo surgical treatment for chronic rhinosinusitis (CRS).Study DesignProspective observational cohort study.MethodsPatients with CRS completed the EQ‐5D questionnaire preoperatively and annually for five years following endoscopic sinus surgery. Paired t‐tests and McNemar's tests were used to compare preoperative and postoperative scores. Mixed‐effects modeling was used for multivariate analysis.ResultsAmong 1296 patients enrolled in our study, 812 (74.7%) completed the postoperative survey at one year and 336 (38.9%) completed it at five years. There was a significant and sustained reduction of patients reporting pain/discomfort (74.9% vs. 58.0%, p < 0.001) and anxiety/depression (49.6% vs. 38.1%, p = 0.01) out to five years. Frequency of problems reported in the usual activity domain decreased at one year and was sustained through year four (30.6% vs 19.7%, p = 0.003). After multivariable modeling, female gender (p = 0.02), prior sinus surgery (p = 0.01), tobacco use (p = 0.038), headaches (p = 0.013), allergies (p = 0.001), diabetes (p = 0.022), hypertension (p = 0.036), higher preoperative SNOT‐22 score (p < 0.001), and a lower preoperative Lund‐Mackay score (p < 0.001) were associated with significantly worse EQ‐5D HUV over time. Similarly, a worse EQ‐5D Visual Analog Scale (VAS) over time was associated with allergies (p = 0.03), diabetes (p < 0.001), hypertension (p = 0.04), higher preoperative SNOT‐22 score (p < 0.001), and prior sinus surgery (p < 0.001).ConclusionPatients with chronic rhinosinusitis experience significant sustained improvements in health‐related quality of life up to five years after ESS as measured by the EQ‐5D instrument.Level of EvidenceLevel 2 Laryngoscope, 134:2592–2601, 2024
Signals of change in the Campania region rainfall regime: An analysis of extreme precipitation indices (2002–2021)
Authors: Capozzi Vincenzo , Rocco Armando , Annella Clizia , Cretella Viviana , Fusco Giannetta , Budillon Giorgio 
Published: December 2023

AbstractIt is widely known that precipitation is a key variable of the hydrological cycle that is strongly affected by recent climate changes. Therefore, there is a growing interest in research activities focused on alteration of rainfall regime, as it conditions the planning of countermeasures against flood and landslide hazards. The available literature about precipitation tendencies over Italian peninsula offers a limited number of studies about recent changes of extreme events and precipitation intensity. This work aims at adding a contribution to fill this research gap, investigating the changes in rainfall regime observed over the 2002–2021 period in the Campania region (southern Italy). To pursue this aim, a dataset including daily precipitation records collected at 107 stations was analysed both through 11 indices developed by the Expert Team on Climate Change Detection and Indices and through the Standardized Precipitation Index in order to detect signals of changes in extreme events and to assess tendencies towards drier or wetter conditions. The Theil‐Sen method and the Mann–Kendall non‐parametric test were employed to evaluate the trends and their statistical significance. The main results emerging from this work are (i) an increasing tendency in precipitation intensity and in the frequency of occurrence of heavy rainfall events in autumn, mainly in the northern part of the region and in the mountainous areas, (ii) an upward trend of the duration of the longest wet spell in the coastal areas and (iii) an increasing trend of dry spells in spring and in summer in the Gulf of Salerno.
Nurse managers' perceptions of patient‐centred care and its influence on quality nursing care and nurse job satisfaction: Empirical research qualitative
Authors: Abugre Dominic , Bhengu Busisiwe R. 
Published: December 2023

AbstractAimTo explore nurse managers' perceptions of patient‐centered care (PCC), its influence on quality nursing care, nurse job satisfaction, and to provide baseline data for a context‐driven PCC model.DesignThe study utilized a qualitative, phenomenological design, employing individual in‐depth interviews to collect data on nurse managers' PCC perceptions until data saturation.MethodsSampling involved purposive selection of Northern Ghana, random selection of the tertiary hospital cluster with the three participating hospitals, and purposive sampling of the nine nurse managers. Data analysis employed thematic analysis based on a six‐phase framework. Methodological trustworthiness was ensured through various strategies including prolonged engagement, supervisor discussions and crosschecking with interviewees.ResultsThree main themes emerged from the study including nurse managers' conceptualization of PCC, perceived patient‐centred practices and its influence on nursing quality and job satisfaction. The findings emphasized the patient's individuality, cultural values, holistic care, the importance of strong nurse‐patient relationships and a patient‐centric environment. The nurse managers perceived PCC as positively influencing quality nursing care and nurse job satisfaction. The findings offer nuanced insights into nurse managers' perspectives on patient‐centeredness and highlight areas for improvement.
Allergy History and Immunotherapy Response in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Authors: Alkhatib Hosam H. , Maroun Christopher A. , Guller Meytal , Cooper Dylan J. , Wu Evan S. , Eisele David W. , Fakhry Carole , Pardoll Drew , Seiwert Tanguy Y. , Zhu Gangcai , Mandal Rajarsi 
Published: December 2023

AbstractObjectiveThis study examines the association between patient‐reported allergy history and immune checkpoint inhibition (ICI) response in patients with recurrent or metastatic head and neck squamous cell carcinoma (RMHNSCC).Study DesignRetrospective cohort study.SettingAcademic tertiary care hospital.MethodsData were collected from the electronic medical records on baseline age, sex, allergy history, human papillomavirus status, T‐stage, N‐stage, smoking status, and survival for patients with and without an allergy history. The primary outcome was ICI response defined as complete or partial response by the RECIST criteria. Chi‐square and logistic regression analyses were conducted to compare rates and odds of ICI response. Kaplan‐Meier analyses were used to compare survival between groups.ResultsOur study included 52 patients with an allergy history and 36 patients without an allergy history. The groups were similar in age, sex, HPV status, smoking status, and T‐ and N‐stage. Patients with an allergy history (17/52, 32.1%) had a greater ICI response rate than patients without allergy history (4/36, 11.1%) (P = .02). After adjusting for HPV, patients with allergies had 3.93 (1.19‐13.00) times increased odds of ICI response compared to patients without allergies. The median progression‐free survival was 6.0 and 4.2 months for patients with and without an allergy history respectively (log‐rank, P = .04). The median overall survival was 25.0 and 11.1 months for patients with and without an allergy history respectively (log‐rank, P = .002).ConclusionPatient‐reported allergy history was associated with ICI response in patients with RMHNSCC, underscoring the potential clinical utility of allergy history in estimating ICI response.
Management of Bilateral Vocal Fold Paralysis: A Systematic Review
Authors: Lechien Jérôme R. , Hans Stéphane , Mau Ted 
Published: December 2023

AbstractObjectiveTo review the current literature about epidemiology, etiologies and surgical management of bilateral vocal fold paralysis (BVFP).Data SourcesPubMED, Scopus, and Cochrane Library.Review MethodsA systematic review of the literature on epidemiology, etiologies, and management of adult patients with BVFP was conducted through preferred reporting items for systematic reviews and meta‐analyses statements by 2 investigators.ResultsOf the 360 identified papers, 245 were screened, and of these 55 were considered for review. The majority (76.6%) of BVFP cases are iatrogenic. BVFP requires immediate tracheotomy in 36.2% of cases. Laterofixation of the vocal fold was described in 9 studies and is a cost‐effective alternative procedure to tracheotomy while awaiting potential recovery. Unilateral and bilateral posterior transverse cordotomy outcomes were reported in 9 and 7 studies, respectively. Both approaches are associated with a 95.1% decannulation rate, adequate airway volume, but voice quality worsening. Unilateral/bilateral partial arytenoidectomy data were described in 4 studies, which reported lower decannulation rate (83%) and better voice quality outcome than cordotomy. Revision rates and complications vary across studies, with complications mainly involving edema, granuloma, fibrosis, and scarring. Selective posterior cricoarytenoid reinnervation is being performed by more surgeons and should be a promising addition to the BVFP surgical armamentarium.ConclusionDepending on techniques, the management of BVFP may be associated with several degrees of airway improvements while worsened or unchanged voice quality. The heterogeneity between studies, the lack of large‐cohort controlled randomized studies and the confusion with posterior glottic stenosis limit the draw of clear conclusion about the superiority of some techniques over others.
Research on the lightweight design and multilevel optimization method of B‐pillar of hybrid material based on side‐impact safety and multicriteria decision‐making
Authors: Zhang Shuai , Lu Dongzhen , Huang Ming , Li Ruixu , Li Zhao , Xu Wenchao 
Published: December 2023

AbstractThis paper designs and optimizes a new structure hybrid material B‐pillar assembly. Establish a finite element analysis model for the side impact test of an electric vehicle to verify the model's accuracy. Construct a finite element model of the hybrid material B‐pillar assembly. Combined with the static performance analysis of the B‐pillar, the laminate design of the carbon fiber composite B‐pillar reinforcement plate and optimization. For the outer and inner panels of the B‐pillar, the surrogate model method and the multiobjective optimization method are combined to set 11 design variables and 13 responses. The optimal Latin hypercube design method was used to randomly sample each design variable and fit the radial basis function (RBF) approximate model. The modified second‐generation non‐dominated sorting genetic algorithm (MNSGA‐II) was used to carry out multiobjective optimization of the mixed material B‐pillar assembly, and the multicriteria decision‐making method was used to obtain the optimal solution for the Pareto solution set. A drop weight impact test was performed on the hybrid material B‐pillar assembly. The results showed that the peak collision force of the hybrid material B‐pillar was reduced by 43.7% compared with the original steel B‐pillar, the specific energy absorption was increased by 17.5%, and the side impact safety performance was better. After optimization, the weight of the mixed material B‐column was reduced by 26.44%. The improvement rates of the intrusion amount at P2 and the intrusion speed at P1 were 23.99% and 0.63%, respectively, and the lightweight effect and side impact safety were significantly improved.Highlights
The finite element analysis parameters of carbon fiber composite materials were constructed through experiments, and the basis for simulation analysis under various working conditions of the B‐pillar based on performance‐driven optimization was established.
A hybrid material B‐pillar design method is proposed, which consists of a variable‐thickness high‐strength steel B‐pillar outer plate, a variable‐thickness high‐strength steel B‐pillar inner plate, and a carbon fiber composite B‐pillar reinforcement plate.
The super layer of the carbon fiber composite B‐pillar reinforcement plate was optimized and the laying plan of the carbon fiber composite B‐pillar reinforcement plate was determined.
Performance‐driven optimization is adopted to realize the collaboration of multilevel design and optimization methods such as B‐pillar conceptual design, detailed design, and multiobjective optimization.
A modified NSGA‐II algorithm was proposed and combined with the multicriteria decision‐making method and the entropy‐weighted gray relation analysis method to determine the Pareto optimal solution and the optimal design scheme for the mixed material B‐pillar.
Recurrent reactive hypoglycemia due to clozapine‐induced glucose intolerance: A case report
Authors: Kawai Fumihiko , Watanabe Satsuki , Ebihara Hirotaka , Shimizu Naoki , Oshima Shiori , Okai Hiroshi , Murata Yoshiko , Arai Hisatoshi , Matsuo Koji 
Published: December 2023

AbstractBackgroundAlthough diabetes is one of the most common side effects of clozapine, a medication for the treatment of schizophrenia, to the best of our knowledge no study exists on clozapine‐induced glucose intolerance or hypoglycemia in patients with schizophrenia.Case PresentationWe report a case of schizophrenia with repeated reactive hypoglycemia due to abnormal glucose tolerance during clozapine treatment. During clozapine administration in patients with schizophrenia, it is necessary to monitor physical and psychiatric symptoms due to reactive hypoglycemia and hyperglycemia. If abnormal glucose tolerance is a concern, it should be promptly detected using blood or oral glucose tolerance tests.ConclusionEarly intervention for impaired glucose tolerance may prevent clozapine discontinuation due to diabetes or hyperglycemia.
New antipsychotic prescription and recurrent infections among adult sepsis survivors: A population‐based cohort study
Authors: Ferraris Augusto , Szmulewicz Alejandro G. , Burry Lisa , Phipps Amanda , Wunsch Hannah , Scales Damon C. , Angriman Federico 
Published: December 2023

AbstractPurposeAntipsychotic agents, which may increase the risk of infection through dopaminergic dysregulation, are prescribed to a fraction of patients following critical illness. We compared the rate of recurrent sepsis among patients who filled a prescription for antipsychotics with high‐ or low‐D2 affinity.MethodsPopulation‐based cohort with active comparator design. We included sepsis survivors older than 65 years with intensive care unit admission and new prescription of antipsychotics in Ontario 2008–2019. The primary outcome were recurrent sepsis episodes within 1 year of follow‐up. Patients who filled a prescription within 30 days of hospital discharge for high‐D2 affinity antipsychotics (e.g., haloperidol) were compared with patients who filled a prescription within 30 days of hospital discharge for low‐D2 affinity antipsychotics (e.g., quetiapine). Multivariable zero‐inflated Poisson regression models with robust standard errors adjusting for confounding at baseline were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI).ResultsOverall, 1879 patients filled a prescription for a high‐D2, and 1446 patients filled a prescription for a low‐D2 affinity antipsychotic. Patients who filled a prescription for a high‐D2 affinity antipsychotic did not present a higher rate of recurrent sepsis during 1 year of follow‐up, compared with patients who filled a prescription for a low‐D2 affinity antipsychotic (IRR: 1.12; 95% CI: 0.94, 1.35).ConclusionsWe did not find conclusive evidence of a higher rate of recurrent sepsis associated with the prescription of high‐D2 affinity antipsychotics (compared with low‐D2 affinity antipsychotics) by 1 year of follow‐up in adult sepsis survivors with intensive care unit admission.
The Impact of Fine Particulate Matters (PM10, PM2.5) from Incense Smokes on the Various Organ Systems: A Review of an Invisible Killer
Authors: Yadav Virendra Kumar , Bijekar Sangha , Gacem Amel , Alkahtani Abdullah M , Yadav Krishna Kumar , Alreshidi Maha Awjan , Kumar Pankaj , Ghosh Tathagata , Verma Rakesh Kumar , Mishra Sunidhi , Patel Ashish , Choudhary Nisha 
Published: December 2023

AbstractThe drastic increase in industrialization has led to numerous adverse effects on the environment and human health. Respiratory tract disorders are one of the major emerging global health issues that lead to a high mortality rate every year. The quality of indoor and outdoor air has lowered in the last decade.The quality of indoor air has deteriorated by cooking, smoking, and burning incense sticks or smoke. The smoke released from incense and incense sticks contains gaseous products (carbon monoxide, nitrogen dioxide, and oxide of sulfur), particular matter (PM10, PM2.5), volatile organic compounds (VOCs), and polycyclic aromatic hydrocarbons (PAHs). These toxic components released from various incense sources pose a significant risk to human health and the environment. The inhalation and exposure of smoke from various incenses is hazardous to health as it inevitably culminates in deadly organ‐related diseases. With such insights, the present review article focuses on the characteristic attributes of particulate matter released from incense and other sources emphasizing healthcare and environmental concerns.
Anopheles mosquitoes in Morocco: implication for public health and underlined challenges for malaria re‐establishment prevention under current and future climate conditions
Authors: Abdelkrim Outammassine , Said Zouhair , Souad Loqman 
Published: December 2023

AbstractBACKGROUNDThe potential reappearance and/or expansion of vector‐borne diseases is one of the terrifying issues awaiting humanity in the context of climate change. The presence of competent Anopheles vectors, as well as suitable environmental circumstances, may result in the re‐emergence of autochthonous Malaria, after years of absence. In Morocco, international travel and migration movements from Malaria‐endemic areas have recently increased the number of imported cases, raising awareness of Malaria's possible reintroduction. Using machine learning we developed model predictions, under current and future (2050) climate, for the prospective distribution of Anopheles claviger, Anopheles labranchiae, Anopheles multicolor, and Anopheles sergentii implicated or incriminated in Malaria transmission.RESULTSAll modelled species are expected to find suitable habitats and have the potential to become established in the northern and central parts of the country, under present‐day conditions. Distinct changes in the distributions of the four mosquitoes are to be expected under climate change. Even under the most optimistic scenario, all investigated species are likely to acquire new habitats that are now unsuitable, placing further populations in danger. We also observed a northward and altitudinal shift in their distribution towards higher altitudes.CONCLUSIONClimate change is expected to expand the potential range of malaria vectors in Morocco. Our maps and predictions offer a way to intelligently focus efforts on surveillance and control programmes. To reduce the threat of human infection, it is crucial for public health authorities, entomological surveillance teams, and control initiatives to collaborate and intensify their actions, continuously monitoring areas at risk. © 2023 Society of Chemical Industry.