bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical experimentation of the gastrointestinal tract: a systematic review
Authors: Durcan Ciara , Hossain Mokarram , Chagnon Grégory , Perić Djordje , Girard Edouard 
Published: November 2023

AbstractThe gastrointestinal (GI) organs of the human body are responsible for transporting and extracting nutrients from food and drink, as well as excreting solid waste. Biomechanical experimentation of the GI organs provides insight into the mechanisms involved in their normal physiological functions, as well as understanding of how diseases can cause disruption to these. Additionally, experimental findings form the basis of all finite element (FE) modelling of these organs, which have a wide array of applications within medicine and engineering. This systematic review summarises the experimental studies that are currently in the literature (n= 247) and outlines the areas in which experimentation is lacking, highlighting what is still required in order to more fully understand the mechanical behaviour of the GI organs. These include (i) more human data, allowing for more accurate modelling for applications within medicine, (ii) an increase in time-dependent studies, and (iii) more sophisticated in vivo testing methods which allow for both the layer- and direction-dependent characterisation of the GI organs. The findings of this review can also be used to identify experimental data for the readers’ own constitutive or FE modelling as the experimental studies have been grouped in terms of organ (oesophagus, stomach, small intestine, large intestine or rectum), test condition (ex vivo or in vivo), number of directions studied (isotropic or anisotropic), species family (human, porcine, feline etc.), tissue condition (intact wall or layer-dependent) and the type of test performed (biaxial tension, inflation–extension, distension (pressure-diameter), etc.). Furthermore, the studies that investigated the time-dependent (viscoelastic) behaviour of the tissues have been presented.
Variation in reproductive success in a fragmented Meadow Pipit population: a role for vegetation succession?
Authors: Anger Fabian , Förschler Marc I. , Anthes Nils 
Published: November 2023

AbstractMost farmland birds experience strong declines across Europe. These declines are typically associated with agricultural intensification but research on alternative local causes remains scarce. We investigated variation in reproductive success as a potential driver for the observed population declines in a fragmented population of the Meadow PipitAnthus pratensis, a representative inhabitant of extensively managed mountain grasslands across Europe. Intense nest surveys in the entire Meadow Pipit metapopulation of the Northern Black Forest (SW Germany) between 2020 and 2022 provided information on reproductive success for 53 females distributed across nine habitat patches along an 18 km ridge of the Northern Black Forest. Hatching dates delayed by approx. 5.0 days per 100 m altitude and were almost 10 days later in a year with cold and rainy spring weather. Mean reproductive success per female and year (3.45 fledglings) was low compared to literature values (approx. 4.5) and may thus drive ongoing population declines. Mayfield nest survival estimates (approx. 51% across the nesting period) were comparably high, with most nest failures linked with predation or adverse weather. Low reproductive success further associated with comparably small clutch sizes and low fractions of second broods in habitat patches characterized by homogeneously dense swards. We suggest that restoration through extensive permanent cattle grazing coupled with succession control may be a key factor to increase population productivity.
Additive and non-additive genetic variance in juvenile Sitka spruce (Picea sitchensis Bong. Carr)
Authors: Ilska J.J. , Tolhurst D.J. , Tumas H. , Maclean J. P. , Cottrell J. , Lee S.J. , Mackay J. , Woolliams J.A. 
Published: November 2023

AbstractMany quantitative genetic models assume that all genetic variation is additive because of a lack of data with sufficient structure and quality to determine the relative contribution of additive and non-additive variation. Here the fractions of additive (fa) and non-additive (fd) genetic variation were estimated in Sitka spruce for height, bud burst and pilodyn penetration depth. Approximately 1500 offspring were produced in each of three sib families and clonally replicated across three geographically diverse sites. Genotypes from 1525 offspring from all three families were obtained by RADseq, followed by imputation using 1630 loci segregating in all families and mapped using the newly developed linkage map of Sitka spruce. The analyses employed a new approach for estimating fa and fd, which combined all available genotypic and phenotypic data with spatial modelling for each trait and site. The consensus estimate for fa increased with age for height from 0.58 at 2 years to 0.75 at 11 years, with only small overlap in 95% support intervals (I95). The estimated fa for bud burst was 0.83 (I95=[0.78, 0.90]) and 0.84 (I95=[0.77, 0.92]) for pilodyn depth. Overall, there was no evidence of family heterogeneity for height or bud burst, or site heterogeneity for pilodyn depth, and no evidence of inbreeding depression associated with genomic homozygosity, expected if dominance variance was the major component of non-additive variance. The results offer no support for the development of sublines for crossing within the species. The models give new opportunities to assess more accurately the scale of non-additive variation.
Taxing energy to tackle greenhouse gases: evaluating the role of financial risk in high-income economies
Authors: Hassan Taimoor 
Published: November 2023

AbstractEnergy, a basic input to the economic system, plays a pivotal function in development; at the same time, it raises concerns and hurdles to global economies as a result of negative externalities associated with its usage. Economies set various measures to limit these negative externalities and encourage citizens toward renewable energy utilization. Considering a panel of high-income economies over the period of 1990–2020, we empirically examine whether energy-related tax policies (ENT) are helpful to tackle the issue of energy-related greenhouse gas emissions (ENGHGs). Furthermore, we also investigate the role of digitalization (DIG) and financial risk (FINR) for its possible impact on ENGHGs. The advanced econometric techniques include diagnostic tests, Method of Moment Quantile Regression (MMQR), for robustness validation quantile regression, and finally Dumitrescu and Hurlin panel causality check. The findings reveal that ENT policies of selected economies are not helpful to limit ENGHGs in 25th and 50th quantiles effectively. Nevertheless, due to the progressive rise in ENT in the 75th and 90th quantiles, ENT significantly helps to smoothen the path towards a sustainable future. Furthermore, GDP increases, while improvement in FINR decreases ENGHGs. As the selected economies are developed and high-income, it is suggested that a progressive rise in ENT may further limit the issue of ENGHGs.
Hyperoxia can Induce Lung Injury by Upregulating AECII Autophagy and Apoptosis Via the mTOR Pathway
Authors: Ren Yingcong , Qin Song , Liu Xinxin , Feng Banghai , Liu Junya , Zhang Jing , Yuan Ping , Yu Kun , Mei Hong , Chen Miao 
Published: November 2023

AbstractOxygen therapy is a crucial medical intervention, but it is undeniable that it can lead to lung damage. The mTOR pathway plays a pivotal role in governing cell survival, including autophagy and apoptosis, two phenomena deeply entwined with the evolution of diseases. However, it is unclarified whether the mTOR pathway is involved in hyperoxic acute lung injury (HALI). The current study aims to clarify the molecular mechanism underlying the pathogenesis of HALI by constructing in vitro and in vivo models using H2O2 and hyperoxia exposure, respectively. To investigate the role of mTOR, the experiment was divided into five groups, including normal group, injury group, mTOR inhibitor group, mTOR activator group, and DMSO control group. Western blotting, Autophagy double labeling, TUNEL staining, and HE staining were applied to evaluate protein expression, autophagy activity, cell apoptosis, and pathological changes in lung tissues. Our data revealed that hyperoxia can induce autophagy and apoptosis in Type II alveolar epithelial cell (AECII) isolated from the treated rats, as well as injuries in the rat lung tissues; also, H2O2 stimulation increased autophagy and apoptosis in MLE-12 cells. Noticeably, the experiments performed in both in vitro and in vivo models proved that the mTOR inhibitor Rapamycin (Rapa) functioned synergistically with hyperoxia or H2O2 to promote AECII autophagy, which led to increased apoptosis and exacerbated lung injury. On the contrary, activation of mTOR with MHY1485 suppressed autophagy activity, consequently resulting in reduced apoptosis and lung injury in H2O2-challenged MLE-12 cells and hyperoxia-exposed rats. In conclusion, hyperoxia caused lung injury via mTOR-mediated AECII autophagy.
Neuritic Plaques — Gateways to Understanding Alzheimer’s Disease
Authors: Tsering Wangchen , Prokop Stefan 
Published: November 2023

AbstractExtracellular deposits of amyloid-β (Aβ) in the form of plaques are one of the main pathological hallmarks of Alzheimer’s disease (AD). Over the years, many different Aβ plaque morphologies such as neuritic plaques, dense cored plaques, cotton wool plaques, coarse-grain plaques, and diffuse plaques have been described in AD postmortem brain tissues, but correlation of a given plaque type with AD progression or AD symptoms is not clear. Furthermore, the exact trigger causing the development of one Aβ plaque morphological subtype over the other is still unknown. Here, we review the current knowledge about neuritic plaques, a subset of Aβ plaques surrounded by swollen or dystrophic neurites, which represent the most detrimental and consequential Aβ plaque morphology. Neuritic plaques have been associated with local immune activation, neuronal network dysfunction, and cognitive decline. Given that neuritic plaques are at the interface of Aβ deposition, tau aggregation, and local immune activation, we argue that understanding the exact mechanism of neuritic plaque formation is crucial to develop targeted therapies for AD.
The Remarkable Diversity of Parasitic Flowering Plants in Colombia
Authors: González Favio , Pabón-Mora Natalia 
Published: November 2023

AbstractParasitic plants have evolved independently in 12 Angiosperm orders. Nine of them (Boraginales, Cucurbitales, Ericales, Lamiales, Laurales, Malvales, Santalales, Solanales, and Zygophyllales) are represented in Colombia by 17 families, 44 genera and 246 species, including facultative (37) and obligate (187) hemiparasites, holoexoparasites (19) and holoendoparasites (3). Cladocolea coriacea (Loranthaceae) is reported for the first time in Colombia. One genus (Sanguisuga, Cytinaceae) and 69 species (28.04%) are endemic to the country. Endemism decreases with elevation, ranging from 26 species (37.68%) below 1000 m, to one species (1.44%) above 4000 m. Speciation in Aetanthus, Psittacanthus and Tristerix (Loranthaceae), Dendrophthora and Phoradendron (Viscaceae), and Castilleja and Neobartsia (Orobanchaceae) was likely prompted by the Andean uplift. The highest number of species (169) are found in the Andean Region, whereas the Orinoco Region contains the lowest number (29). Dry forests and thickets, and coastal vegetation of the Caribbean Region are the preferred ecosystems for Krameria (Krameriaceae), Sanguisuga, Acanthosyris (Cervantesiaceae), Maracanthus (Loranthaceae), Ximenia (Ximeniaceae), Lennoa (Ehretiaceae), and Anisantherina (Orobanchaceae). Orobanche minor, recently introduced to the country, is the only potential weed for crops between 2500 and 3200 m in the Eastern Cordillera. Convergent lifeforms include: the obligate, twining stem holoparasitic Cassytha (Lauraceae) and Cuscuta (Convolvulaceae); the root holoexoparasitic Sanguisuga, Mitrastemon (Mitrastemonaceae), all Balanophoraceae, and Lennoa; and the root obligate hemiparasitic Krameria, Gaiadendron (Loranthaceae), and all Cervantesiaceae, Opiliaceae, Schoepfiaceae, Strombosiaceae and Ximeniaceae. Holoendoparasitism occurs only in Apodanthaceae, whereas root facultative hemiparasitism is restricted to the Orobanchaceae.
Influence of Various Alloying Element Additions on Microstructure and Magnetic and Mechanical Properties and Corrosion Behavior of Cast Fe–Ga–Z Shape Memory Alloys
Authors: El-Bagoury Nader , El-Hadad Shimaa , Shoeib Madiha 
Published: November 2023

AbstractFe–Ga alloys are attractive materials where high mechanical strength, toughness, ductility, and large low-field magnetostriction combine to give unique properties. Adding alloying elements is an effective method to further enhance these properties. In order to integrate these alloys into the operating environments, e.g., micro-robots and magnetic actuators, the corrosion behavior should be addressed. This work analyzed the microstructure, magnetization, hardness, and corrosion properties of Fe81Ga19−xZx (X = 5 at.% of Ni, Mn, or Ti, and 2 at.% Al; separately) alloys. X-ray diffraction (XRD), scanning electron microscope-electron (SEM), vibrating sample magnetometer (VSM), Vickers hardness (HV), and a potentiostat were used for characterization. XRD revealed that the prominent peak belongs to the bcc disorder A2 phase and a small peak for the cubic order L12 phase. Fe–Ga–Al alloy got the maximum Ms value, while Fe–Ga–Mn alloy gained the lowest one. However, the Mr and Hc properties for Fe–Ga alloy were distinctly improved by adding Al but slightly affected by doping Mn. Addition of Ti achieved the highest hardness, followed by Ni, Mn, and Al. The microstructure of the different alloys significantly influenced their corrosion behavior. Fe–Ga–Mn alloy with the fine globular grain structure showed the lowest corrosion rate (C R = 0.03 mm/year), whereas Fe–Ga–Al alloy with the coarse longitudinal grains exhibited the highest corrosion rate (C R = 0.19 mm/year).
CHA2DS2-VASc score as a predictor of clinical outcomes in hospitalized patients with and without chronic kidney disease
Authors: Gigante Antonietta , Imbimbo Giovanni , Andreini Martina , Proietti Marco , Palladino Mariangela , Molfino Alessio , Alunni Fegatelli Danilo , Muscaritoli Maurizio 
Published: November 2023

Abstract
Background
High CHA2DS2-VASc score (Congestive heart failure, Hypertension, Age > 75 years, Diabetes mellitus, prior Stroke or transient ischemic attack or thromboembolism, Vascular disease, Age 65–74 and Sex category) was associated with adverse clinical outcomes in different settings.
The aim of the present study was to evaluate the association between CHA2DS2-VASc score and R2CHA2DS2-VASc score (which includes renal impairment) with in-hospital mortality and length of hospital stay in patients hospitalized in an internal medicine ward.

Methods
We enrolled 983 consecutive patients admitted during 3 years in an internal medicine ward. R2CHA2DS2-VASc score was calculated by adding 2 points to CHA2DS2-VASc for the presence of chronic kidney disease (CKD), defined according to K-DOQI. The primary outcome was a composite of all-cause mortality and length of hospital stay > 10 days.

Results
Patients with CKD stages 3–5 presented with increased CHA2DS2-VASc vs stages 1–2 (p < 0.001). The composite outcome occurred in 47.3% of inpatients. Multivariable linear logistic regression analyses adjusted for presence of infectious diseases and cancer, with the occurrence of composite outcome showed an adjusted OR of 1.349 (95% CI 1.248–1.462) and 1.254 (95% CI 1.179–1.336) for CHA2DS2-VASc and R2CHA2DS2-VASc scores, respectively. No differences were found in the association between CHA2DS2-VASc and R2CHA2DS2-VASc scores with the composite outcome (AUC 0.631 vs 0.630), and furthermore, adding the presence/absence of infectious diseases during hospitalization and positive cancer history to the models increased the AUC (0.667 and 0.663).

Conclusions
Incrementally higher CHA2DS2-VASc score is associated with increased length of hospital stay and mortality in patients hospitalized in an internal medicine ward, regardless of the presence of CKD.

Graphical abstract
Developing Chinese Private International Law for Transnational Civil and Commercial Litigation: The 2024 New Chinese Civil Procedure Law
Authors: Huang Jie 
Published: November 2023

AbstractOn 1 September 2023, the Standing Committee of the National People’s Congress amended the Chinese Civil Procedure Law which will come into effect on 1 January 2024 (‘the 2024 CPL’). The 2024 CPL brings significant changes to the entire procedure of transnational civil and commercial litigation in China covering jurisdiction, service of process, the taking of evidence abroad, and the recognition and enforcement of foreign judgments. It is critical for foreign states, courts, and parties which conduct business in China to understand this new legal development and to prepare for the changes. Adopting comparative-law and empirical research methods, this commentary aims to explain the new provisions for transnational civil litigation in the 2024 CPL and how they may be implemented in practice.
Zeros transfer for recursively defined polynomials
Authors: Heim Bernhard , Neuhauser Markus , Tröger Robert 
Published: November 2023

AbstractThe zeros of D’Arcais polynomials, also known as Nekrasov–Okounkov polynomials, dictate the vanishing of the Fourier coefficients of powers of the Dedekind eta functions. These polynomials satisfy difference equations of hereditary type with non-constant coefficients. We relate the D’Arcais polynomials to polynomials satisfying a Volterra difference equation of convolution type. We obtain results on the transfer of the location of the zeros. As an application, we obtain an identity between Chebyshev polynomials of the second kind and 1-associated Laguerre polynomials. We obtain a new version of the Lehmer conjecture and bounds for the zeros of the Hermite polynomials.
Towards Safe Autonomous Driving: Decision Making with Observation-Robust Reinforcement Learning
Authors: He Xiangkun , Lv Chen 
Published: November 2023

AbstractMost real-world situations involve unavoidable measurement noises or perception errors which result in unsafe decision making or even casualty in autonomous driving. To address these issues and further improve safety, automated driving is required to be capable of handling perception uncertainties. Here, this paper presents an observation-robust reinforcement learning against observational uncertainties to realize safe decision making for autonomous vehicles. Specifically, an adversarial agent is trained online to generate optimal adversarial attacks on observations, which attempts to amplify the average variation distance on perturbed policies. In addition, an observation-robust actor-critic approach is developed to enable the agent to learn the optimal policies and ensure that the changes of the policies perturbed by optimal adversarial attacks remain within a certain bound. Lastly, the safe decision making scheme is evaluated on a lane change task under complex highway traffic scenarios. The results show that the developed approach can ensure autonomous driving performance, as well as the policy robustness against adversarial attacks on observations.
Curing treatments of silica gel for fire-retardant glass by intumescence
Authors: Cotini Oscar , Ataollahi Narges , Di Maggio Rosa 
Published: November 2023

Abstract
Silica hydrogels are used as fire-retardant materials due to the occurrence of intumescence that limits heat and mass transfer. They act as heat-sink, through continuous endothermic condensation reactions, meantime shrinking to a more connected network, towards the correspondent crystalline compound. Which compositions and treatments amplify this phenomenon is still of interest. To this aim, two silica sols containing two different complexing agents: ethylene glycol and glycerol has been prepared and analyzed. The samples were subjected to different treatments to induce gelation and densification: exposure to ultraviolet or microwave or infrared irradiation. Thermogravimetric analysis coupled with differential scanning calorimetry (TG-DSC) and scanning electron microscopy analyses has been also carried out. Moreover, dynamic mechanical spectroscopy (DMS) let to evaluate simultaneously the mechanical and intumescence behavior of the gels at increasing curing times for each type of irradiation. Intumescence of gels occurs up to 200 °C and appears as an endothermal group of peaks visible on the heat-flux DSC curves. DMS analyses let to assess that a MW cured glycerol-containing gel (GL-0-MW 6d) shows a glass transition above 150 °C, measured as the maximum of damping peak. Accordingly, this sample is a good option for the application: a few bubbles nucleate and grow fast at high temperature.

Article Highlights

Transparent fire doors contain silica gel, which absorbs heat and releases water by foaming. Two different silica gels were synthetized using different chelating agents.

The foaming depends on the reagents used to produce the gel, on the treatments for stabilizing it and also on ageing.

Both foaming and consolidation of the gel were studied with thermogravimetric and dynamic-mechanical analysis.
The impact of increasing non-albicans Candida trends on diagnostics in immunocompromised patients
Authors: Abdel-Hamid Rasha M. , El-Mahallawy Hadir A. , Abdelfattah Nesma E. , Wassef Mona A. 
Published: November 2023

AbstractInvasive candidiasis (IC) represents a growing concern worldwide, with a considerable increase in non-albicans Candida (NAC) species. The study's primary goal was to determine if species identification by semi-nested PCR (sn-PCR) with primers for the five most prevalent Candida species is sufficient to deal with the current trends of Candida infections in cancer patients. Over one year, Candida isolates were collected from samples of patients with hematological and solid organ tumors in a single center. Species of Candida were identified by chromagar and multiplex sn-PCR using specific primers for Candida albicans, Candida tropicalis, Candida glabrata, Candida krusei, and the Candida parapsilosis complex. Most Candida infection episodes are caused by NAC species (70.5% of 105 isolates). Rare species (14 isolates) accounted for 13.3% of isolates and were not identified by sn-PCR using the five most common Candida species primers. More than half of these rare species caused candidemia in cancer patients (57.1%; p = 0.011). The risk factor for candidiasis was recent surgeries (p = 0.020) in adults and chemotherapy in pediatric patients (p = 0.006). Prolonged hospitalization and genitourinary tract cancer were significantly associated with invasive infections (p = 0.005 and 0.049, respectively). Recent surgery was a significant risk factor associated with C. parapsilosis and C. glabrata infections (P = 0.038 and 0.003, respectively), while C. tropicalis was significantly more common in patients with hematological malignancies (P = 0.012). Techniques with a broader identification spectrum than the major five Candida species are crucial for the optimal management of cancer patients.