bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumption of added fats and oils in the European Prospective Investigation into Cancer and Nutrition (EPIC) centres across 10 European countries as assessed by 24-hour dietary recalls
Authors: Linseisen J , Bergström E , Gafá L , González CA , Thiébaut A , Trichopoulou A , Tumino R , Sánchez C Navarro , Garcia C Martínez , Mattisson I , Nilsson S , Welch A , Spencer EA , Overvad K , Tjønneland A , Clavel-Chapelon F , Kesse E , Miller AB , Schulz M , Botsi K , Naska A , Sieri S , Sacerdote C , Ocké MC , Peeters PHM , Skeie G , Engeset D , Charrondière UR , Slimani N 
Published: March 2003

AbstractObjective:To evaluate the consumption of added fats and oils across the European centres and countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC).Design and setting:24-Hour dietary recalls were collected by means of standardised computer-guided interviews in 27 redefined EPIC centres across 10 European countries.Subjects:From an initial number of 36 900 subjects, single dietary recalls from 22 924 women and 13 031 men in the age range of 35–74 years were included.Results:Mean daily intake of added fats and oils varied between 16.2 g (Varese, Italy) and 41.1 g (Malmö, Sweden) in women and between 24.7 g (Ragusa, Italy) and 66.0 g (Potsdam, Germany) in men. Total mean lipid intake by consumption of added fats and oils, including those used for sauce preparation, ranged between 18.3 (Norway) and 37.2 g day−1 (Greece) in women and 28.4 (Heidelberg, Germany) and 51.2 g day−1 (Greece) in men. The Mediterranean EPIC centres with high olive oil consumption combined with low animal fat intake contrasted with the central and northern European centres where fewer vegetable oils, more animal fats and a high proportion of margarine were consumed. The consumption of added fats and oils of animal origin was highest in the German EPIC centres, followed by the French. The contribution of added fats and oils to total energy intake ranged from 8% in Norway to 22% in Greece.Conclusions:The results demonstrate a high variation in dietary intake of added fats and oils in EPIC, providing a good opportunity to elucidate the role of dietary fats in cancer aetiology.
Meat consumption in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts: results from 24-hour dietary recalls
Authors: Linseisen J , Kesse E , Slimani N , Bueno-de-Mesquita HB , Ocké MC , Skeie G , Kumle M , Iraeta M Dorronsoro , Gómez P Morote , Janzon L , Stattin P , Welch AA , Spencer EA , Overvad K , Tjønneland A , Clavel-Chapelon F , Miller AB , Klipstein-Grobusch K , Lagiou P , Kalapothaki V , Masala G , Giurdanella MC , Norat T , Riboli E 
Published: March 2003

AbstractObjective:To evaluate meat intake patterns in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts.Design and setting:24-Hour dietary recalls were assessed within the framework of a prospective cohort study in 27 centres across 10 European countries by means of standardised computer-assisted interviews.Subjects:In total, 22 924 women and 13 031 men aged 35–74 years.Results:Mean total meat intake was lowest in the ‘health-conscious’ cohort in the UK (15 and 21 g day−1 in women and men, respectively) and highest in the north of Spain, especially in San Sebastian (124 and 234 g day−1, respectively). In the southern Spanish centres and in Naples (Italy), meat consumption was distinctly lower than in the north of these countries. Central and northern European centres/countries showed rather similar meat consumption patterns, except for the British and French cohorts. Differences in the intake of meat sub-groups (e.g. red meat, processed meat) across EPIC were even higher than found for total meat intake. With a few exceptions, the Mediterranean EPIC centres revealed a higher proportion of beef/veal and poultry and less pork or processed meat than observed in central or northern European centres. The highest sausage consumption was observed for the German EPIC participants, followed by the Norwegians, Swedish, Danish and Dutch.Conclusions:The results demonstrate distinct differences in meat consumption patterns between EPIC centres across Europe. This is an important prerequisite for obtaining further insight into the relationship between meat intake and the development of chronic diseases.
Consumption of dairy products in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: data from 35955 24-hour dietary recalls in 10 European countries
Authors: Hjartåker A , Lagiou A , Slimani N , Lund E , Chirlaque MD , Vasilopoulou E , Zavitsanos X , Berrino F , Sacerdote C , Ocké MC , Peeters PHM , Engeset D , Skeie G , Aller A , Amiano P , Berglund G , Nilsson S , McTaggart A , Spencer EA , Overvad K , Tjønneland A , Clavel-Chapelon F , Linseisen J , Schulz M , Hemon B , Riboli E 
Published: March 2003

AbstractObjectives:To describe and compare the consumption of dairy products in cohorts included in the European Prospective Investigation into Cancer and Nutrition (EPIC).Methods:Data from single 24-hour dietary recall interviews collected through a highly standardised computer-based program (EPIC-SOFT) in 27 redefined centres in 10 European countries between 1995 and 2000. From a total random sample of 36 900, 22 924 women and 13 031 men were selected after exclusion of subjects under 35 and over 74 years of age.Results:A high total consumption of dairy products was reported in most of the centres in Spain and in the UK cohort sampled from the general population, as well as in the Dutch, Swedish and Danish centres. A somewhat low consumption was reported in the Greek centre and in some of the Italian centres (Ragusa and Turin). In all centres and for both sexes, milk constituted the dairy sub-group with the largest proportion (in grams) of total dairy consumption, followed by yoghurt and other fermented milk products, and cheese. Still, there was a wide range in the contributions of the different dairy sub-groups between centres. The Spanish and Nordic centres generally reported a high consumption of milk, the Swedish and Dutch centres reported a high consumption of yoghurt and other fermented milk products, whereas the highest consumption of cheese was reported in the French centres.Conclusion:The results demonstrate both quantitative and qualitative disparities in dairy product consumption among the EPIC centres. This offers a sound starting point for analyses of associations between dairy intake and chronic diseases such as cancer.
Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study
Authors: Welch AA , Lund E , Amiano P , Dorronsoro M , Brustad M , Kumle M , Rodriguez M , Lasheras C , Janzon L , Jansson J , Luben R , Spencer EA , Overvad K , Tjønneland A , Clavel-Chapelon F , Linseisen J , Klipstein-Grobusch K , Benetou V , Zavitsanos X , Tumino R , Galasso R , Bueno-de-Mesquita HB , Ocké MC , Charrondière UR , Slimani N 
Published: March 2003

AbstractObjective:To describe and compare the consumption of total fish (marine foods) and the fish sub-groups – white fish, fatty fish, very fatty fish, fish products and crustacea, in participants from the European Investigation into Cancer and Nutrition (EPIC) study.Design:Cross-sectional analysis of dietary intake using a computerised standardised 24-hour recall interview. Crude means, means and standard errors adjusted by age, season and day of the week were calculated, stratified by centre and gender.Setting:Twenty-seven redefined centres in the 10 European countries participating in the EPIC study.Subjects:In total, 35 955 subjects (13 031 men and 22 924 women), aged 35–74 years, selected from the main EPIC cohort.Results:A six- to sevenfold variation in total fish consumption exists in women and men, between the lowest consumption in Germany and the highest in Spain. Overall, white fish represented 49% and 45% of the intake of total fish in women and men, respectively, with the greatest consumption in centres in Spain and Greece and the least in the German and Dutch centres. Consumption of fatty fish reflected that of total fish. However, the greatest intake of very fatty fish was in the coastal areas of northern Europe (Denmark, Sweden and Norway) and in Germany. Consumption of fish products was greater in northern than in southern Europe, with white fish products predominating in centres in France, Italy, Spain, The Netherlands and Norway. Intake of roe and roe products was low. The highest consumption of crustacea was found in the French, Spanish and Italian centres. The number of fish types consumed was greater in southern than in northern Europe. The greatest variability in consumption by day of the week was found in the countries with the lowest fish intake.Conclusions:Throughout Europe, substantial geographic variation exists in total fish intake, fish sub-groups and the number of types consumed. Day-to-day variability in consumption is also high.
Patterns of alcohol consumption in 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) project
Authors: Sieri S , Agudo A , Kesse E , Klipstein-Grobusch K , San-José B , Welch AA , Krogh V , Luben R , Allen N , Overvad K , Tjønneland A , Clavel-Chapelon F , Thiébaut A , Miller AB , Boeing H , Kolyva M , Saieva C , Celentano E , Ocké MC , Peeters PHM , Brustad M , Kumle M , Dorronsoro M , Feito A Fernandez , Mattisson I , Weinehall L , Riboli E , Slimani N 
Published: March 2003

Abstractbjective:The aim of this study was to compare the quantities of alcohol and types of alcoholic beverages consumed, and the timing of consumption, in centres participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). These centres, in 10 European countries, are characterised by widely differing drinking habits and frequencies of alcohol-related diseases.Methods:We collected a single standardised 24-hour dietary recall per subject from a random sample of the EPIC cohort (36 900 persons initially and 35 955 after exclusion of subjects under 35 and over 74 years of age). This provided detailed information on the distribution of alcohol consumption during the day in relation to main meals, and was used to determine weekly consumption patterns. The crude and adjusted (by age, day of week and season) means of total ethanol consumption and consumption according to type of beverage were stratified by centre and sex.Results:Sex was a strong determinant of drinking patterns in all 10 countries. The highest total alcohol consumption was observed in the Spanish centres (San Sebastian, 41.4 g day−1) for men and in Danish centres (Copenhagen, 20.9 g day−1) for women. The lowest total alcohol intake was in the Swedish centres (Umeå, 10.2 g day−1) in men and in Greek women (3.4 g day−1). Among men, the main contributor to total alcohol intake was wine in Mediterranean countries and beer in the Dutch, German, Swedish and Danish centres. In most centres, the main source of alcohol for women was wine except for Murcia (Spain), where it was beer. Alcohol consumption, particularly by women, increased markedly during the weekend in nearly all centres. The German, Dutch, UK (general population) and Danish centres were characterised by the highest percentages of alcohol consumption outside mealtimes.Conclusions:The large variation in drinking patterns among the EPIC centres provides an opportunity to better understand the relationship between alcohol and alcohol-related diseases.
Trends in self-reported past alcoholic beverage consumption and ethanol intake from 1950 to 1995 observed in eight European countries participating in the European Investigation into Cancer and Nutrition (EPIC)
Authors: Klipstein-Grobusch K , Slimani N , Krogh V , Keil U , Boeing H , Overvad K , Tjønneland A , Clavel-Chapelon F , Thiébaut A , Linseisen J , Schulze MB , Lagiou P , Papadimitrou A , Saieva C , Veglia F , Bueno-de-Mesquita HB , Peeters PHM , Kumle M , Brustad M , García C Martínez , Barricarte A , Berglund G , Weinehall L , Mulligan A , Allen N , Ferrari P , Riboli E 
Published: March 2003

AbstractObjective:To describe the trends of self-reported past consumption of alcoholic beverages and ethanol intake from 1950 to 1995 within the European Prospective Investigation into Cancer and Nutrition (EPIC).Design:Data on consumption of beer/cider, wine and liqueur/spirits were obtained retrospectively at age 20, 30 and 40 years to calculate average consumption and ethanol intake for the time periods 1950–1975 (at age 20), 1960–1985 (at age 30) and 1970–1995 (at age 40). Regression analysis was conducted with the time period data to assess trends in past alcoholic beverage consumption and ethanol intake with time.Setting:The EPIC project.Subjects:In total, 392 064 EPIC participants (275 249 women and 116 815 men) from 21 study centres in eight European countries.Results:Generally, increases in beer/cider consumption were observed for most EPIC centres for 1950–1975, 1960–1985 and 1970–1995. Trends in wine consumption differed according to geographical location: downward trends with time were observed for men in southern European EPIC centres, upward trends for those in middle/northern European study centres. For women, similar but less pronounced trends were observed. Because wine consumption was the major contributor to ethanol intake for both men and women in most study centres, time trends for ethanol intake showed a similar geographical pattern to that of wine consumption.Conclusion:The different trends in alcoholic beverage consumption and ethanol intake suggest that information depicting lifetime history of ethanol intake should be included in analyses of the relationship between ethanol and chronic diseases, particularly in multi-centre studies such as EPIC.
Diversity of dietary patterns observed in the European Prospective Investigation into Cancer and Nutrition (EPIC) project
Authors: Slimani N , Fahey M , Welch A , Wirfält E , Stripp C , Bergström E , Linseisen J , Schulze MB , Bamia C , Chloptsios Y , Veglia F , Panico S , Bueno-de-Mesquita HB , Ocké MC , Brustad M , Lund E , González CA , Barcos A , Berglund G , Winkvist A , Mulligan A , Appleby P , Overvad K , Tjønneland A , Clavel-Chapelon F , Kesse E , Ferrari P , Van Staveren WA , Riboli E 
Published: March 2003

AbstractObjective:To describe the diversity in dietary patterns existing across centres/regions participating in the European Prospective Investigation into Cancer and Nutrition (EPIC).Design and setting:Single 24-hour dietary recall measurements were obtained by means of standardised face-to-face interviews using the EPIC-SOFT software. These have been used to present a graphic multi-dimensional comparison of the adjusted mean consumption of 22 food groups.Subjects:In total, 35 955 men and women, aged 35–74 years, participating in the EPIC nested calibration study.Results:Although wide differences were observed across centres, the countries participating in EPIC are characterised by specific dietary patterns. Overall, Italy and Greece have a dietary pattern characterised by plant foods (except potatoes) and a lower consumption of animal and processed foods, compared with the other EPIC countries. France and particularly Spain have more heterogeneous dietary patterns, with a relatively high consumption of both plant foods and animal products. Apart from characteristics specific to vegetarian groups, the UK ‘health-conscious’ group shares with the UK general population a relatively high consumption of tea, sauces, cakes, soft drinks (women), margarine and butter. In contrast, the diet in the Nordic countries, The Netherlands, Germany and the UK general population is relatively high in potatoes and animal, processed and sweetened/refined foods, with proportions varying across countries/centres. In these countries, consumption of vegetables and fruit is similar to, or below, the overall EPIC means, and is low for legumes and vegetable oils. Overall, dietary patterns were similar for men and women, although there were large gender differences for certain food groups.Conclusions:There are considerable differences in food group consumption and dietary patterns among the EPIC study populations. This large heterogeneity should be an advantage when investigating the relationship between diet and cancer and formulating new aetiological hypotheses related to dietary patterns and disease.
Petrogenesis of Mesozoic, Peraluminous Granites in the Lamoille Canyon Area, Ruby Mountains, Nevada, USA
Authors: Lee Sang-Yun , Barnes Calvin G. , Snoke Arthur W. , Howard Keith A. , Frost Carol D. 
Published: April 2003

AbstractTwo groups of closely associated, peraluminous, two-mica granitic gneiss were identified in the area. The older, sparsely distributed unit is equigranular (EG) with initial εNd ∼ − 8·8 and initial 87Sr/86Sr ∼0·7098. Its age is uncertain. The younger unit is Late Cretaceous (∼80 Ma), pegmatitic, and sillimanite-bearing (KPG), with εNd from −15·8 to −17·3 and initial 87Sr/86Sr from 0·7157 to 0·7198. The concentrations of Fe, Mg, Na, Ca, Sr, V, Zr, Zn and Hf are higher, and K, Rb and Th are lower in the EG. Major- and trace-element models indicate that the KPG was derived by muscovite dehydration melting (&lt;35 km depth) of Neoproterozoic metapelitic rocks that are widespread in the eastern Great Basin. The models are broadly consistent with anatexis of crust tectonically thickened during the Sevier orogeny; no mantle mass or heat contribution was necessary. As such, this unit represents one crustal end-member of regional Late Cretaceous peraluminous granites. The EG was produced by biotite dehydration melting at greater depths, with garnet stable in the residue. The source of the EG was probably Paleoproterozoic metagraywacke. Because EG magmatism probably pre-dated Late Cretaceous crustal thickening, it required heat input from the mantle or from mantle-derived magma.
Disruption of theFATBGene in Arabidopsis Demonstrates an Essential Role of Saturated Fatty Acids in Plant Growth
Authors: Bonaventure Gustavo , Salas Joaquin J. , Pollard Michael R. , Ohlrogge John B. 
Published: April 2003

AbstractAcyl-acyl carrier protein thioesterases determine the amount and type of fatty acids that are exported from the plastids. To better understand the role of the FATB class of acyl-acyl carrier protein thioesterases, we identified an Arabidopsis mutant with a T-DNA insertion in the FATB gene. Palmitate (16:0) content of glycerolipids of the mutant was reduced by 42% in leaves, by 56% in flowers, by 48% in roots, and by 56% in seeds. In addition, stearate (18:0) was reduced by 50% in leaves and by 30% in seeds. The growth rate was reduced in the mutant, resulting in 50% less fresh weight at 4 weeks compared with wild-type plants. Furthermore, mutant plants produced seeds with low viability and altered morphology. Analysis of individual glycerolipids revealed that the fatty acid composition of prokaryotic plastid lipids was largely unaltered, whereas the impact on eukaryotic lipids varied but was particularly severe for phosphatidylcholine, with a &gt;4-fold reduction of 16:0 and a 10-fold reduction of 18:0 levels. The total wax load of fatb-ko plants was reduced by 20% in leaves and by 50% in stems, implicating FATB in the supply of saturated fatty acids for wax biosynthesis. Analysis of C18 sphingoid bases derived from 16:0 indicated that, despite a 50% reduction in exported 16:0, the mutant cells maintained wild-type levels of sphingoid bases, presumably at the expense of other cell components. The growth retardation caused by the fatb mutation was enhanced in a fatb-ko act1 double mutant in which saturated fatty acid content was reduced further. Together, these results demonstrate the in vivo role of FATB as a major determinant of saturated fatty acid synthesis and the essential role of saturates for the biosynthesis and/or regulation of cellular components critical for plant growth and seed development.
Genome-Wide Analysis of NBS-LRR–Encoding Genes in Arabidopsis[W]
Authors: Meyers Blake C. , Kozik Alexander , Griego Alyssa , Kuang Hanhui , Michelmore Richard W. 
Published: April 2003

AbstractThe Arabidopsis genome contains ∼200 genes that encode proteins with similarity to the nucleotide binding site and other domains characteristic of plant resistance proteins. Through a reiterative process of sequence analysis and reannotation, we identified 149 NBS-LRR–encoding genes in the Arabidopsis (ecotype Columbia) genomic sequence. Fifty-six of these genes were corrected from earlier annotations. At least 12 are predicted to be pseudogenes. As described previously, two distinct groups of sequences were identified: those that encoded an N-terminal domain with Toll/Interleukin-1 Receptor homology (TIR-NBS-LRR, or TNL), and those that encoded an N-terminal coiled-coil motif (CC-NBS-LRR, or CNL). The encoded proteins are distinct from the 58 predicted adapter proteins in the previously described TIR-X, TIR-NBS, and CC-NBS groups. Classification based on protein domains, intron positions, sequence conservation, and genome distribution defined four subgroups of CNL proteins, eight subgroups of TNL proteins, and a pair of divergent NL proteins that lack a defined N-terminal motif. CNL proteins generally were encoded in single exons, although two subclasses were identified that contained introns in unique positions. TNL proteins were encoded in modular exons, with conserved intron positions separating distinct protein domains. Conserved motifs were identified in the LRRs of both CNL and TNL proteins. In contrast to CNL proteins, TNL proteins contained large and variable C-terminal domains. The extant distribution and diversity of the NBS-LRR sequences has been generated by extensive duplication and ectopic rearrangements that involved segmental duplications as well as microscale events. The observed diversity of these NBS-LRR proteins indicates the variety of recognition molecules available in an individual genotype to detect diverse biotic challenges.
Members of the Arabidopsis Dynamin-Like Gene Family, ADL1, Are Essential for Plant Cytokinesis and Polarized Cell Growth[W]
Authors: Kang Byung-Ho , Busse James S. , Bednarek Sebastian Y. 
Published: April 2003

AbstractPolarized membrane trafficking during plant cytokinesis and cell expansion are critical for plant morphogenesis, yet very little is known about the molecular mechanisms that guide this process. Dynamin and dynamin-related proteins are large GTP binding proteins that are involved in membrane trafficking. Here, we show that two functionally redundant members of the Arabidopsis dynamin-related protein family, ADL1A and ADL1E, are essential for polar cell expansion and cell plate biogenesis. adl1A-2 adl1E-1 double mutants show defects in cell plate assembly, cell wall formation, and plasma membrane recycling. Using a functional green fluorescent protein fusion protein, we show that the distribution of ADL1A is dynamic and that the protein is localized asymmetrically to the plasma membrane of newly formed and mature root cells. We propose that ADL1-mediated membrane recycling is essential for plasma membrane formation and maintenance in plants.