bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-consistent nanoflare heating in model active regions: MHD avalanches in curved coronal arcades
Authors: Reid J. , Threlfall J. , Hood A. W. 
Published: September 2023

AbstractMHD avalanches involve small, narrowly localized instabilities spreading across neighbouring areas in a magnetic field. Cumulatively, many small events release vast amounts of stored energy. Straight cylindrical flux tubes are easily modelled, between two parallel planes, and can support such an avalanche: one unstable flux tube causes instability to proliferate, via magnetic reconnection, and then an ongoing chain of like events. True coronal loops, however, are visibly curved, between footpoints on the same solar surface. With 3D MHD simulations, we verify the viability of MHD avalanches in the more physically realistic, curved geometry of a coronal arcade. MHD avalanches thus amplify instability across strong solar magnetic fields and disturb wide regions of plasma. Contrasting with the behaviour of straight cylindrical models, a modified ideal MHD kink mode occurs, more readily and preferentially upwards in the new, curved geometry. Instability spreads over a region far wider than the original flux tubes and than their footpoints. Consequently, sustained heating is produced in a series of ‘nanoflares’ collectively contributing substantially to coronal heating. Overwhelmingly, viscous heating dominates, generated in shocks and jets produced by individual small events. Reconnection is not the greatest contributor to heating, but is rather the facilitator of those processes that are. Localized and impulsive, heating shows no strong spatial preference, except a modest bias away from footpoints, towards the loop’s apex. Remarkable evidence emerges of ‘campfire’ like events, with simultaneous, reconnection-induced nanoflares at separate sites along coronal strands, akin to recent results from Solar Orbiter. Effects of physically realistic plasma parameters, and the implications for thermodynamic models, with energetic transport, are discussed.
Spectroscopic Detection of Alfvénic MHD Waves in the Sunspot Chromosphere
Authors: Chae Jongchul 
Published: September 2023

AbstractAlfvénic waves are regarded as an important process in understanding coronal heating, solar wind acceleration, and the fractionization of low first-ionization-potential (FIP) elements. Recently, significant progresses have been made in the detection of propagating Alfvénic waves in the solar chromosphere using two different methods: the imaging method and the spectroscopic method. The imaging method detects Alfvénic waves that oscillate in the direction perpendicular to the line of sight, and the spectroscopic method, those that oscillates in the line of sight direction. We have applied the spectroscopic method to the imaging spectral data taken by the FISS on GST at Big Bear. As a result, we detected a number of propagating Alfvénic wave packets, and found that there are two distinct groups: three-minute period waves, and ten-minute period waves.
Observational Signature of Tilt Quenching of Bipolar Magnetic Regions in the Sun
Authors: Jha Bibhuti Kumar , Karak Bidya Binay , Banerjee Dipankar 
Published: September 2023

AbstractIt is believed that the tilt in the bipolar magnetic regions (BMRs) is produced due to a torque induced by the Coriolis force, acting on the diverging flow from the apex of the rising flux tube of the toroidal field in the solar convection zone (SCZ).The BMRs with a strong magnetic field are expected to have reduced tilt as they rise very quickly in the SCZ. This effect can provide the required nonlinear quenching mechanism to suppress the growth of magnetic filed in the dynamo models. Here, we use the magnetograms of the Michelson Doppler Imager (1996–2011) and Helioseismic and Magnetic Imager (2010–2018) to automatically detect the BMRs and look for the signature of tilt quenching. Based on the Bayesian inference method, our results show that the posterior distribution of quenching parameters is Gaussian, and the mean of this distribution agrees with the earlier findings.
Solar cycles reconstructed over the last millennium: Do Waldmeier and Gnevysev-Ohl rules work?
Authors: Similä Markus , Usoskin Ilya 
Published: September 2023

AbstractUsing tree-ring radiocarbon 14C data, solar cycles are now reconstructed for the last millennium, more than doubling the previously known statistic of direct solar observations and giving a new opportunity to validate basic empirical rules connecting solar cycle lengths, strengths and intensities. This includes the Waldmeier rule relating the cycle’s strength to the length of its ascending phase, and the Gnevyshev-Ohl rule suggesting that cycles are paired so that the intensity of an odd solar cycle is higher than that of the preceding even cycle. Using the extended solar-cycle statistic, we found that the Waldmeier rule remains robust for the well-defined solar cycles implying that it is an intrinsic feature of the solar cycle. However, the validity of the Gnevyshev-Ohl rule is not confirmed at any reasonable statistical level, indicating that either the insufficient accuracy of the reconstructed solar cycles or that this rule is not a robust feature.
Modern Sedimentation Patterns in Lake Issyk Kul (Kyrgyzstan), Derived From Surface Sediment and Inlet Stream Samples
Authors: Lenz M. M. , Scheuer R. , Zhang X. , Jaeschke A. , Opitz S. , Leicher N. , Pöllen M. , Xu X. , Rethemeyer J. , Rahmedinov E. , Abdrakhmatov K. , Wennrich V. , Wagner B. 
Published: September 2023

AbstractThis study provides a descriptive characterization of the modern sedimentary processes in Lake Issyk Kul, Kyrgyzstan, important for the selection of a suitable coring or deep‐drilling site, interpretation of future core data and applicability of proxies. The quasi‐equidistant sampling grid of 66 sediment surface samples covers the entirety of the lake basin and is complemented by 10 samples from the major inflows. The methodological approach includes geochemical, granulometric, lipid biomarker, diatom, and statistical analyses. The quantitative and qualitative changes in sediment composition yield information on its generic origin and prevailing transport and depositional environments. The composition of the surface sediments in Issyk Kul is highly heterogenous. Nearshore deposition is mainly controlled by wave action and by fluvial sediment supply with highest quantities of detrital input coming from the high‐energetic, eastern tributaries. Sediments in the deep central basin are mainly produced in situ and dominated by authigenic calcite. Biogenic accumulation is overall low, except for the western extremity of the lake, where the nearshore, shallow‐water, and low‐energetic environment favors aquatic productivity and subsequent preservation of organic material and diatoms. Redeposition of sediments is a dominant process along the slopes across the southern and western basin floor, where run‐out distances of mass movement deposits are up to 5 km. Directional sediment transport by lake currents appears to be less important, except for the transport of very fine‐grained organic matter. Biomarker‐inferred temperature reconstructions suggest lake surface temperatures of ∼15°C in the western littoral zone and in Tyup Bay and a decrease to ∼13°C basinward.
The Influence of ENSO on the Long‐Term Water Storage Anomalies in the Middle‐Lower Reaches of the Yangtze River Basin: Evaluation and Analysis
Authors: Li Xiaolong , Jin Taoyong , Liu Bingshi , Chao Nengfang , Li Fupeng , Cai Zuansi 
Published: September 2023

AbstractRecent extreme events in the Middle‐Lower reaches of the Yangtze River basin (MLYRB) are proven to be possibly linked to the El Niño‐Southern Oscillation (ENSO) events as indicated by terrestrial water storage anomaly (TWSA). But the relatively short observation time of Gravity Recovery and Climate Experiment series missions (2002–2017; 2018–present) affects the robustness of the evaluation of TWSA. Here, the applicability of four long‐term TWSA data sets (since 1979) in the MLYRB is evaluated first using an evaluation framework including two completely independent tests. After selecting the optimal one, we investigate the effects of ENSO on TWSA in the MLYRB at the basin, subbasin, and grid cell scales, respectively. Results show that ENSO, especially the Eastern Pacific type ENSO has had a significant impact on TWSA variations in the MLYRB and its two subbasins (the Dongting Lake basin and the Poyang Lake basin) since 1979 with correlation coefficients at 0.56–0.65 and time lags at 5–6 months. However, TWSAs in the other two subbasins (the Hanjiang River basin and the Mainstream River basin) have almost no correlation with ENSO. Further analysis reveals that compared with human activity that has a limited impact on TWSA, precipitation is one of the key inducements for regional water storage changes in these two subbasins, and the no correlation between ENSO and TWSA is mainly caused by the weak link between ENSO and precipitation.
Rivers and Water Systems as Weapons and Casualties of the Russia‐Ukraine War
Authors: Gleick Peter , Vyshnevskyi Viktor , Shevchuk Serhii 
Published: September 2023

AbstractThe geophysical, hydrological, and ecological consequences of the Russia‐Ukraine war for the major rivers and water infrastructure in Ukraine are addressed here, focused on the dams and reservoirs of the Dnipro (Dnieper) River and major tributaries, up to and including the destruction of the Kakhovka Dam in June 2023, using remote sensing systems, on‐the‐ground reports, and official sources. The rivers have long played a role as physical barriers during conflicts, but in the current war, water and built water systems have also been targeted for attacks and used as both offensive and defensive weapons. Among the consequences of the conflict have been both direct and indirect effects on civilian populations, agriculture, military operations, water supplies and quality, and natural ecosystems. An historical review shows that such attacks have occurred in the past, but the extent and severity of the current violence appear unprecedented, raising important questions of international law and how international legal and scientific communities should respond.
A Radial Standing Pc5‐6 Wave and Its Energy Coupling With Field Line Resonance Within the Dusk‐Sector Magnetosphere
Authors: Zhou Yi‐Jia , He Fei , Zhang Xiao‐Xin , Archer Martin O. , Lin Yu , Ma Han , Tian An‐Min , Yao Zhong‐Hua , Wei Yong , Ni Binbin , Liu Wenlong , Zong Qiu‐Gang , Pu Zu‐Yin 
Published: September 2023

AbstractGlobal ultra‐low frequency (ULF) oscillations are believed to play a significant role in the mass, energy, and momentum transport within the Earth's magnetosphere. In this letter, we observe a ∼1.2 mHz radial standing wave in the dusk‐sector magnetosphere accompanied by the field line resonance (FLR) on 16 July 2017. The frequency estimation from the simple box model also confirms the radial standing wave. The essential characteristics of FLR are concurrently identified at the dusk‐sector magnetosphere and the conjugated ground location. Further, the radial standing wave dissipates energy into upper atmosphere to enhance the local aurora by coupling itself to the FLR. The magnetospheric dominant 1.2/1.1 mHz ULF waves plausibly correspond well with the discrete ∼1 mHz magnetosheath ion dynamic pressure/velocity oscillation, suggesting this radial standing wave and FLR in the flank magnetosphere may be triggered by the solar‐wind and/or magnetosheath dynamic pressure/velocity fluctuations.
Shifts of the Recirculation Pathways in Central Fram Strait Drive Atlantic Intermediate Water Variability on Northeast Greenland Shelf
Authors: McPherson R. A. , Wekerle C. , Kanzow T. 
Published: September 2023

AbstractIncreased oceanic heat transport plays a key role in the accelerated mass loss of Greenland's marine‐terminating glaciers. The melt rate of major glaciers in Northeast Greenland (NEG) is controlled by ocean variability, in particular warm Atlantic Intermediate Water (AIW), on the continental shelf. A high‐resolution configuration of the ocean sea‐ice model FESOM2.1 is assessed at local and regional scales, and used to investigate the drivers of AIW temperature variability on the NEG continental shelf. The seasonal to decadal variability of AIW is characterized, featuring both pronounced interannual fluctuations and a long‐term warming trend. A major source of AIW is Atlantic Water (AW) originating from the West Spitsbergen Current that recirculates in Fram Strait. AW anomalies are advected westwards and partly control the AIW temperatures on the continental shelf. Increased AIW temperatures are also connected to pronounced northern and central branches of recirculating AW in Fram Strait, and enhanced AW temperatures more regionally. The strengthening of the pathways brings more warmer AIW onto the northern part of the NEG continental shelf. There, it circulates anti‐cyclonically and results in shelf‐wide warming. Regional atmospheric forcing is connected to the changes in the AW circulation. The strengthening of the northern AW branches is likely caused by anticyclonic wind anomalies over the Barents Sea that drive an enhanced northward AW transport in Fram Strait. Thus, controlled by a combination of both upstream and regionally forced circulation conditions, the changes in local AIW temperatures may also affect the oceanic heat transport reaching the Central Arctic Ocean.
Extensional Faulting Around Kolumbo Volcano, Aegean Sea—Relationships Between Local Stress Fields, Fault Relay Ramps, and Volcanism
Authors: Crutchley Gareth J. , Karstens Jens , Preine Jonas , Hübscher Christian , Fossen Haakon , Kühn Michel 
Published: September 2023

AbstractThe Christiana‐Santorini‐Kolumbo (CSK) volcanic field has hosted more than 100 explosive eruptions in the past 250,000 years, including the 1650 CE eruption of Kolumbo Volcano. Previous studies have established a link between regional tectonics and volcanism in the CSK volcanic field. While 2D seismic reflection data have given valuable insight into regional faulting, detailed fault zone characterization has been precluded by the sparsely spaced profiles. Using 3D seismic reflection data around Kolumbo Volcano, we provide the first 3D characterization of fault zones in the CSK volcanic field. Beneath the volcano's northwestern flank, and farther to the northwest, normal faults are predominantly NE‐SW trending, with mean fault trends between 044° and 049°. Normal faults beneath the southeastern flank are slightly more north‐oriented, with mean fault trends between 028° and 038°. Our detailed fault zone analysis reveals clear NW‐SE directed extension around the volcano, consistent with published focal mechanisms from microseismicity. The Kolumbo Fault Zone, ∼6 km northwest of Kolumbo Volcano, is characterized by distinct relay ramps between major overstepping normal faults. Regional 2D seismic profiles reveal a previously undocumented volcanic cone directly above the fault zone. Magma ascent to this cone has likely exploited enhanced vertical permeability associated with distributed deformation within a relay ramp. We suggest that fault relay structures may play an important role, over a range of spatial scales, in focusing magma ascent within the CSK volcanic field.
Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
Authors: Miranda-Olivos Romina , Baenas Isabel , Steward Trevor , Granero Roser , Pastor Antoni , Sánchez Isabel , Juaneda-Seguí Asier , del Pino-Gutiérrez Amparo , Fernández-Formoso José A. , Vilarrasa Nuria , Guerrero-Pérez Fernando , Virgili Nuria , López-Urdiales Rafael , Jiménez-Murcia Susana , de la Torre Rafael , Soriano-Mas Carles , Fernández-Aranda Fernando 
Published: September 2023

AbstractAnorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula; pFWE < 0.001) and the left supplementary motor area (NAcc-SMA; pFWE < 0.001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment.
The sex-specific factor SOA controls dosage compensation in Anopheles mosquitoes
Authors: Kalita Agata Izabela , Marois Eric , Kozielska Magdalena , Weissing Franz J. , Jaouen Etienne , Möckel Martin M. , Rühle Frank , Butter Falk , Basilicata M. Felicia , Keller Valsecchi Claudia Isabelle 
Published: September 2023

AbstractThe Anopheles mosquito is one of thousands of species in which sex differences play a central part in their biology, as only females need a blood meal to produce eggs. Sex differentiation is regulated by sex chromosomes, but their presence creates a dosage imbalance between males (XY) and females (XX). Dosage compensation (DC) can re-equilibrate the expression of sex chromosomal genes. However, because DC mechanisms have only been fully characterized in a few model organisms, key questions about its evolutionary diversity and functional necessity remain unresolved1. Here we report the discovery of a previously uncharacterized gene (sex chromosome activation (SOA)) as a master regulator of DC in the malaria mosquito Anopheles gambiae. Sex-specific alternative splicing prevents functional SOA protein expression in females. The male isoform encodes a DNA-binding protein that binds the promoters of active X chromosomal genes. Expressing male SOA is sufficient to induce DC in female cells. Male mosquitoes lacking SOA or female mosquitoes ectopically expressing the male isoform exhibit X chromosome misregulation, which is compatible with viability but causes developmental delay. Thus, our molecular analyses of a DC master regulator in a non-model organism elucidates the evolutionary steps that lead to the establishment of a chromosome-specific fine-tuning mechanism.
Multitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease
Authors: Hou Lei , Xiong Xushen , Park Yongjin , Boix Carles , James Benjamin , Sun Na , He Liang , Patel Aman , Zhang Zhizhuo , Molinie Benoit , Van Wittenberghe Nicholas , Steelman Scott , Nusbaum Chad , Aguet François , Ardlie Kristin G. , Kellis Manolis 
Published: September 2023

AbstractGenetic variants associated with complex traits are primarily noncoding, and their effects on gene-regulatory activity remain largely uncharacterized. To address this, we profile epigenomic variation of histone mark H3K27ac across 387 brain, heart, muscle and lung samples from Genotype-Tissue Expression (GTEx). We annotate 282 k active regulatory elements (AREs) with tissue-specific activity patterns. We identify 2,436 sex-biased AREs and 5,397 genetically influenced AREs associated with 130 k genetic variants (haQTLs) across tissues. We integrate genetic and epigenomic variation to provide mechanistic insights for disease-associated loci from 55 genome-wide association studies (GWAS), by revealing candidate tissues of action, driver SNPs and impacted AREs. Lastly, we build ARE–gene linking scores based on genetics (gLink scores) and demonstrate their unique ability to prioritize SNP–ARE–gene circuits. Overall, our epigenomic datasets, computational integration and mechanistic predictions provide valuable resources and important insights for understanding the molecular basis of human diseases/traits such as schizophrenia.
Learning single-cell perturbation responses using neural optimal transport
Authors: Bunne Charlotte , Stark Stefan G. , Gut Gabriele , del Castillo Jacobo Sarabia , Levesque Mitch , Lehmann Kjong-Van , Pelkmans Lucas , Krause Andreas , Rätsch Gunnar 
Published: September 2023

AbstractUnderstanding and predicting molecular responses in single cells upon chemical, genetic or mechanical perturbations is a core question in biology. Obtaining single-cell measurements typically requires the cells to be destroyed. This makes learning heterogeneous perturbation responses challenging as we only observe unpaired distributions of perturbed or non-perturbed cells. Here we leverage the theory of optimal transport and the recent advent of input convex neural architectures to present CellOT, a framework for learning the response of individual cells to a given perturbation by mapping these unpaired distributions. CellOT outperforms current methods at predicting single-cell drug responses, as profiled by scRNA-seq and a multiplexed protein-imaging technology. Further, we illustrate that CellOT generalizes well on unseen settings by (1) predicting the scRNA-seq responses of holdout patients with lupus exposed to interferon-β and patients with glioblastoma to panobinostat; (2) inferring lipopolysaccharide responses across different species; and (3) modeling the hematopoietic developmental trajectories of different subpopulations.
D-LMBmap: a fully automated deep-learning pipeline for whole-brain profiling of neural circuitry
Authors: Li Zhongyu , Shang Zengyi , Liu Jingyi , Zhen Haotian , Zhu Entao , Zhong Shilin , Sturgess Robyn N. , Zhou Yitian , Hu Xuemeng , Zhao Xingyue , Wu Yi , Li Peiqi , Lin Rui , Ren Jing 
Published: September 2023

AbstractRecent proliferation and integration of tissue-clearing methods and light-sheet fluorescence microscopy has created new opportunities to achieve mesoscale three-dimensional whole-brain connectivity mapping with exceptionally high throughput. With the rapid generation of large, high-quality imaging datasets, downstream analysis is becoming the major technical bottleneck for mesoscale connectomics. Current computational solutions are labor intensive with limited applications because of the exhaustive manual annotation and heavily customized training. Meanwhile, whole-brain data analysis always requires combining multiple packages and secondary development by users. To address these challenges, we developed D-LMBmap, an end-to-end package providing an integrated workflow containing three modules based on deep-learning algorithms for whole-brain connectivity mapping: axon segmentation, brain region segmentation and whole-brain registration. D-LMBmap does not require manual annotation for axon segmentation and achieves quantitative analysis of whole-brain projectome in a single workflow with superior accuracy for multiple cell types in all of the modalities tested.