bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negative online brand engagement: conceptualisation, scale development and validation
Authors: Dong Xinyu , Veloutsou Cleopatra , Morgan-Thomas Anna 
Published: February 2024

PurposeNegative brand engagement represents a pervasive and persistent feature of interactivity in online contexts. Although existing research suggests that consumer negativity is potentially more impactful or detrimental to brands than its positive counterpart, few studies have examined negative brand-related cognitions, feelings and behaviours. Building on the concept of brand engagement, this study aims to operationalise negative online brand engagement.Design/methodology/approachThis paper presents the results of nine studies that contributed to the development and validation of the proposed scale. Building on the concept of engagement, Studies 1–3 enhanced the construct conceptualisation and generated items. Study 4 involved validation with an academic expert panel. The process of measure operationalisation and validation with quantitative data was completed in Studies 5–8. Finally, the scale's nomological validity was assessed in Study 9.FindingsThe results confirm the multidimensional nature of negative online brand engagement. The validated instrument encompasses four dimensions (cognition, affection, online constructive behaviour and online destructive behaviour), captured by 17 items.Originality/valueProgress in understanding and dealing with negative online brand engagement has been hampered by disagreements over conceptualisation and the absence of measures that capture the phenomenon. This work enhances managerial understanding of negativity fostering strategies that protect brand engagement and improve firm performance.
The effects of vitamin D and omega-3 co-supplementation on lipid profile in adults: a systematic review and meta-analysis
Authors: Zamani Mohammad , Sohrabi Zahra , Aghakhani Ladan , Leilami Kimia , Nosratabadi Saeed , Namkhah Zahra , Clark Cain , Haghighat Neda , Asbaghi Omid , Fathi Fatemeh 
Published: February 2024

Purpose
Previous research indicates that vitamin D and omega-3 co-supplementation may benefit overall health, but current evidence regarding its effects on lipid profile remains unclear. The present systematic review and meta-analysis aimed to examine the effects of vitamin D and omega-3 co-supplementation on lipid profile (total cholesterol [TC], low-density lipoprotein [LDL], triglyceride [TG] and high-density lipoprotein [HDL]) in adults.

Design/methodology/approach
In this systematic review and meta-analysis, relevant studies were obtained by searching the PubMed, Scopus and Web of Science databases (from inception to January 2022). Weighted mean differences and 95% confidence intervals were estimated via a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods.

Findings
Pooled analysis of six randomized controlled trials (RCTs) revealed that vitamin D and omega-3 co-supplementation yielded significant reductions in TG (p = 0.631). A pooled analysis of five trials indicated a significant association between omega-3 and vitamin D treatment and reductions in TC (p = 0.001) and LDL (p = 0.001). Although, pooled analyses of omega-3 and vitamin D did not significantly affect HDL.

Originality/value
The findings suggest that vitamin D and omega-3 co-supplementation lowers TG, TC and LDL in adults. Future, large-scale, RCTs on various populations are needed to elucidate further beneficial effects of vitamin D and omega-3 co-supplementation on lipid profile and establish guidelines for clinical practice.
The growth of the real estate corporate bond market in Vietnam: the role of investor sentiment
Authors: Nguyen Nhung Thi , Tuan Nguyen An , Nguyen Dinh Trung 
Published: February 2024

PurposeThis paper aims to examine the effects of investor sentiment on the development of the real estate corporate bond market in Vietnam.Design/methodology/approachThe research uses an autoregressive distributed lag (ARDL) model with quarterly data. Additionally, the study employs Google Trends search data (GVSI) related to topics such as “Real Estate” and “Corporate Bond” to construct a sentiment index.FindingsThe empirical outcomes reveal that real estate market sentiment improves the growth of the real estate corporate bond market, while stock market sentiment reduces it. Also, there is evidence of a long-run negative effect of corporate bond market sentiment on the total value of real estate bond issuance. Further empirical research evidences the short-term effect of sentiment and economic factors on corporate bond development in the real estate industry.Research limitations/implicationsDue to difficulties in collecting data, this paper has the limited sample of 54 valid quarterly observations. Moreover, the sentiment index based on Google search volume data only reflects the interest level of investors, not their attitudes.Practical implicationsThese results yield important implications for policymakers in respect of strengthening the corporate bond market platform and maintaining stability in macroeconomic and monetary policies in order to promote efficient and sustainable market development.Social implicationsThe study offers some suggestions for regulators and governments to improve the real estate corporate bond market.Originality/valueThis is the first quantitative study to examine the effect of sentiment factors on real estate corporate bond development in Vietnam.
“Mining” the herbarium for hyperaccumulators: Discoveries of nickel and zinc (hyper)accumulation in the genus Noccaea (Brassicaceae) through X‐ray fluorescence herbarium scanning
Authors: Jakovljević Ksenija , Mišljenović Tomica , van der Ent Antony , Baker Alan J. M. , Invernón Vanessa R. , Echevarria Guillaume 
Published: February 2024

AbstractX‐ray fluorescence spectroscopy (XRF) is a relatively new method for non‐destructive elemental analysis of herbarium material that meets the scientific interest in being capable of discovering new hyperaccumulator plant species. Since the genus Noccaea (Brassicaceae family) is known to be one of the most numerous in term of the hyperaccumulator plant species it contains, especially those that hyperaccumulate Ni, the herbarium material available worldwide represents a great resource for expanding our knowledge of their elemental profiles. In this first systematic XRF scanning of herbarium specimens of the genus Noccaea, a total of 794 specimens from the collection of the National Museum of Natural History in Paris (MNHN) were analyzed, and the raw values obtained were corrected using regression formulas against inductively coupled plasma atomic emission spectroscopy data. Hyperaccumulation of Ni was detected in 90 specimens covering 21 taxa, with Ni concentrations reaching up to 48,700 mg kg−1 in Noccaea cappadocica, an ultramaficophyte from Syria. Zinc concentrations above the hyperaccumulation threshold were found in 210 specimens covering 23 taxa, most of which belonged to different subspecies of Noccaea caerulescens, with the highest concentration reaching up to 56,200 mg kg−1 in N. caerulescens subsp. caerulescens. Although the accumulation of Ni and Zn is contrasting in most of the specimens studied, in 10 specimens, predominantly belonging to N. caerulescens, simultaneous hyperaccumulation of Ni and Zn was found. This study also revealed previously unknown hyperaccumulation of Ni in several Noccaea taxa, as well as a simultaneous hyperaccumulation of Ni and Zn that needs to be confirmed by further experimental and field studies.
Sizing mudsnails: Applying superpixels to scale growth detection under ocean warming
Authors: MacNeil Liam , Joly Léa J. , Ito Maysa , Steinmann Anna , Mehler Knut , Scotti Marco 
Published: February 2024

Abstract

The expansion of scientific image data holds great promise to quantify individuals, size distributions and traits. Computer vision tools are especially powerful to automate data mining of images and thus have been applied widely across studies in aquatic and terrestrial ecology. Yet marine benthic communities, especially infauna, remain understudied despite their dominance of marine biomass, biodiversity and playing critical roles in ecosystem functioning.

Here, we disaggregated infauna from sediment cores taken throughout the spring transition (April–June) from a near‐natural mesocosm setup under experimental warming (Ambient, +1.5°C, +3.0°C). Numerically abundant mudsnails were imaged in batches under stereomicroscopy, from which we automatically counted and sized individuals using a superpixel‐based segmentation algorithm. Our segmentation approach was based on clustering superpixels, which naturally partition images by low‐level properties (e.g., colour, shape and edges) and allow instance‐based segmentation to extract all individuals from each image.

We demonstrate high accuracy and precision for counting and sizing individuals, through a procedure that is robust to the number of individuals per image (5–65) and to size ranges spanning an order of magnitude (<750 μm to 7.4 mm). The segmentation routine provided at least a fivefold increase in efficiency compared with manual measurements. Scaling this approach to a larger dataset tallied >40k individuals and revealed overall growth in response to springtime warming.

We illustrate that image processing and segmentation workflows can be built upon existing open‐access R packages, underlining the potential for wider adoption of computer vision tools among ecologists. The image‐based approach also generated reproducible data products that, alongside our scripts, we have made freely available. This work reinforces the need for next‐generation monitoring of benthic communities, especially infauna, which can display differential responses to average warming.
Glasdegib with intensive/nonintensive chemotherapy in Japanese patients with untreated acute myeloid leukemia or high‐risk myelodysplastic syndromes
Authors: Izutsu Koji , Ubukawa Kumi , Morishita Takanobu , Onishi Yasushi , Ishizawa Kenichi , Fujii Yosuke , Kimura Nobuyuki , Yokochi Miyuu , Naoe Tomoki 
Published: February 2024

AbstractGlasdegib is a potent, selective, oral inhibitor of the hedgehog signaling pathway. In this phase I study, previously untreated Japanese patients with acute myeloid leukemia (AML) or high‐risk myelodysplastic syndromes were treated with glasdegib (100 mg once daily) combinations: low‐dose cytarabine (20 mg twice daily; cohort 1, n = 6; expansion cohort, n = 15); daunorubicin and cytarabine (60 mg/m2 i.v.; cohort 2, n = 6); or azacitidine (100 mg/m2 i.v.; cohort 3, n = 6). Patients, except cohort 2, were ineligible for intensive chemotherapy. The primary end‐point was dose‐limiting toxicity in cohorts 1–3 and disease‐modifying response in the expansion cohort. Disease‐modifying response rate was tested with the null hypothesis of 6.8%, which was set based on the results from the phase II BRIGHT AML 1003 study (NCT01546038). No dose‐limiting toxicities were observed in cohorts 1 or 3; one patient in cohort 2 experienced a dose‐limiting toxicity of grade 3 erythroderma. The most common grade ≥3 treatment‐related adverse events were neutropenia and thrombocytopenia (66.7% each) in cohort 1 and thrombocytopenia (60.0%) in the expansion cohort. In the expansion cohort, the disease‐modifying response rate was 46.7% (90% confidence interval, 24.4–70.0; p < 0.0001), with all patients achieving either a complete response or complete response with incomplete blood count recovery. Median overall survival was 13.9 months. In this study, the primary disease‐modifying response end‐point with glasdegib plus low‐dose cytarabine was met. The study confirms the safety and efficacy of glasdegib plus low‐dose cytarabine in Japanese patients with AML ineligible for intensive chemotherapy.
Synthesis of peiminine derivatives and its effect on A549 lung cancer‐bearing mice
Authors: Jin Xin , Guo Jianpeng , Lan Meng , Li Gao , Zhang Hui 
Published: February 2024

AbstractTo seek an effective anti‐lung cancer drug, a total of 14 derivatives were synthesized and characterized. The anti‐lung cancer effect of peiminine derivatives were evaluated in vitro and in vivo. The results of MTT and cell apoptosis assays showed that in comparison with peiminine and its other derivatives, compound 1c (indole‐3‐acetic acid‐peiminine ester) exhibited the highest activity with an IC50 value of 12.78 ± 0.64 μM. Compound 1c (10 μM) significantly reduced the levels of IL‐6, TNF‐α, and IL‐1β in A549 cells. In addition, the qRT‐PCR results showed that compound 1c (10 μM) reduced the mRNA levels of TNF‐α, mTOR, Bcl‐2, Akt1, PI3K, and p65 and increased those of Bax and caspase‐9. Next, the anti‐lung cancer activity of compound 1c (5 mg/kg) was evaluated in A549‐bearing nude mice. It was revealed that the tumor size and weight were significantly inhibited after treatment with compound 1c. And the levels of IL‐6, TNF‐α, and IL‐1β were decreased in mouse tumors. Finally, the latent mechanism of compound 1c was explored by western blot analysis. It was revealed that compound 1c could decrease the expressions of NF‐κB, Bcl‐2, PI3K, Akt, and mTOR and increase the expressions of Bax and caspase‐9 abundance. In conclusion, compound 1c exhibits an inhibitory effect on lung cancer, which was found to occur via inhibition of the PI3K/AKT/mTOR/NF‐κB signaling pathway, thus representing a potential new lead compound for application in lung cancer therapy.
HSYA prevents IL‐1β‐induced human chondrocyte damage in osteoarthritis by inhibiting NF‐κB activation
Authors: Shen Jiaying , Sheng Qi , Gao Manman , Li Junhong , Zhang Zhen , Wang Fuan , Zhou Zhiyu , Wang Jinping 
Published: February 2024

AbstractThe progression of osteoarthritis (OA) requires the involvement of inflammation, in which chondrocyte damage plays a significant role. Hydroxysafflor yellow A (HSYA), the main active component in the medical and edible dual‐purpose plant safflower, has previously shown anti‐inflammatory effects in various diseases. However, the specific impact of HSYA on OA remains unclear. Here, we investigate the potential role and underlying mechanism of HSYA in chondrocyte damage during the progression of OA. The viability of C28/I2 and iCell‐0092a chondrocytes was measured by CCK8 assay at different concentrations (2.5, 10, 40, and 160 μM). The gene expression of the extracellular matrix was revealed by q‐PCR 24 h after IL‐1β treatment. ROS production and levels of pro‐inflammatory cytokines in C28/I2 cells treated with HSYA were measured by immunoflurescence stating and q‐PCR. The impact of HSYA on the extracellular matrix and inflammation in IL‐1β‐induced OA were detected by western blot, q‐PCR, and immunofluorescence staining. We assessed the effect of HSYA and NF‐κB signaling pathway‐related genes by bioinformatics analysis and conducted molecular docking to assess the interaction of HSYA with a combined protein residue molecule ligand. Western blot was employed to investigate NF‐κB transcription factors in chondrocyte metabolism. HSYA was found to reduce excessive ROS production induced by IL‐1β stimuli, inhibit the expression of matrix metalloproteinase 13, interleukin 6, and tumor necrosis factor‐α, and increase the expression of Type II collagen and SRY‐box transcription factor 9 (p < .05). Mechanistically, HSYA interacted with nuclear factor κB, inhibiting the nuclear translocation and phosphorylation level of NF‐κB p65, and decreasing the phosphorylation and degradation of IκBα (p < .05). In conclusion, HSYA ameliorates inflammation and cartilage damage in OA by inhibiting the NF‐κB pathway, suggesting its potential application as a therapeutic agent for OA treatment.
Stride length and cerebellar regulation: Key features of early gait disorder in cerebral small vessel disease
Authors: Mo Yuting , Ji Biying , Ke Zhihong , Mao Chenglu , Jiang Jialiu , Huang Yanan , Qin Ruomeng , Huang Lili , Yang Dan , Hu Zheqi , Xu Yun 
Published: February 2024

AbstractObjectivesGait disorder (GD) is a common problem in cerebral small vessel disease (CSVD). This study aimed to determine (1) the early characteristics of GD in CSVD, (2) cerebellar neuroimaging features related to GD in CSVD, and (3) the association of cognitive impairment with GD.MethodsIn total, 183 subjects were enrolled in this study: patients with CSVD with normal cognitive function (CSVD‐NC) group (64 subjects), patients with CSVD with mild cognitive impairment (CSVD‐MCI) group (66 subjects), and a healthy control (HC) group (53 subjects). The GD patterns were evaluated using the ReadyGo three‐dimensional motion balance testing system. Meanwhile, we analyzed the cerebrum and cerebellum structurally and functionally. Correlation analyses were conducted among gait indicators, neuroimaging features, and neuropsychological tests.ResultsBoth the CSVD‐NC and CSVD‐MCI groups had a reduced stride length, cortical atrophy in the left cerebellum VIIIb, and decreased functional connectivity between the left cerebellum VIIIb and left SFGmed compared with the HC group. In the correlation analysis, the gray matter probability of the left cerebellum VIIIb was closely related to stride length in the HC group. In the CSVD‐MCI group, linguistic function, memory, and attention were significantly correlated with gait performance.ConclusionDecreased stride length was the earliest characteristic of GD in CSVD. Structural and functional regulation of the left cerebellum VIIIb could play a particularly important role in early GD in CSVD.
Associations between impulsivity and fecal microbiota in individuals abstaining from methamphetamine
Authors: Liu Wen , Liu Linzi , Deng Zijing , Liu Ruina , Ma Tao , Xin Yide , Xie Yu , Zhou Yifang , Tang Yanqing 
Published: February 2024

AbstractIntroductionMethamphetamine (MA) abuse is a major public problem, and impulsivity is both a prominent risk factor and a consequence of addiction. Hence, clarifying the biological mechanism of impulsivity may facilitate the understanding of addiction to MA. The microbiota–gut–brain axis was suggested to underlie a biological mechanism of impulsivity induced by MA.MethodsWe therefore recruited 62 MA addicts and 50 healthy controls (HCs) to investigate the alterations in impulsivity and fecal microbiota and the associations between them in the MA group. Thereafter, 25 MA abusers who abstained from MA for less than 3 months were followed up for 2 months to investigate the relationship between impulsivity and microbiota as abstinence became longer. 16S rRNA sequencing was conducted for microbiota identification.ResultsElevated impulsivity and dysbiosis characterized by an increase in opportunistic pathogens and a decrease in probiotics were identified in MA abusers, and both the increased impulsivity and disrupted microbiota tended to recover after longer abstinence from MA. Impulsivity was related to microbiota, and the effect of MA abuse on impulsivity was mediated by microbiota.ConclusionOur findings potentially highlighted the importance of abstention and implicated the significant role of the microbiota–gut–brain axis in the interrelationship between microbiota and behaviors, as well as the potential of microbiota as a target for intervention of impulsivity.
Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPARγ/NF‐κB signaling pathway
Authors: Zhao Tan , Jia Jianping 
Published: February 2024

AbstractAimsWe aimed to explore the role and molecular mechanism of polygalacic acid (PA) extracted from traditional Chinese medicine Polygala tenuifolia in the treatment of Alzheimer's disease (AD).MethodsThe network pharmacology analysis was used to predict the potential targets and pathways of PA. Molecular docking was applied to analyze the combination between PA and core targets. Aβ42 oligomer‐induced AD mice model and microglia were used to detect the effect of PA on the release of pro‐inflammatory mediators and its further mechanism. In addition, a co‐culture system of microglia and neuronal cells was constructed to assess the effect of PA on activating microglia‐mediated neuronal apoptosis.ResultsWe predict that PA might regulate inflammation by targeting PPARγ‐mediated pathways by using network pharmacology. In vivo study, PA could attenuate cognitive deficits and inhibit the expression levels of inflammation‐related factors. In vitro study, PA can also decrease the production of activated microglia‐mediated inflammatory cytokines and reduce the apoptosis of N2a neuronal cells. PPARγ inhibitor GW9662 inversed the neuroprotective effect of PA. Both in vivo and in vitro studies showed PA might attenuate the inflammation through the PPARγ/NF‐κB pathway.ConclusionsPA is expected to provide a valuable candidate for new drug development for AD in the future.
Study on enhancing the union dyeing of cotton/modal blended fabrics with cationic modifier
Authors: Hao Haitao , Chen Xu , Yu Mengyao , Zhu Wenhao , Li Yongqiang 
Published: February 2024

AbstractCotton/modal blended fabrics are favoured by the market because not only do they have the advantages of the dimensional stability of cotton and drape wear resistance of modal, they also overcome their shortcomings, displaying a sense of stiffness and smooth feel. However, because of the differences in the physical and chemical properties between each component, the dyeing of blended fabrics with reactive dyes is prone to problems such as low fixation percentage, different dyeing percentages and colour depth. Here, two cationic modifiers, 2,3‐epoxypropyltrimethyl ammonium chloride (GTA) and methaacryloyloxyethyltrimethyl ammonium chloride (DMC), were applied for cationic modification of cotton/modal blended fabrics, and their role in the dyeability and union dyeing of cotton/modal blended fabrics was studied. The results showed that the K/S and fixation percentage of the blended fabric treated with GTA and DMC cationic agents could be significantly improved compared with the control group, and that the colour fastness of the blended fabric can reach grade 4‐5. Compared with GTA, DMC‐modified cotton/modal blended fabric showed better union dyeing properties because of its better diffusion performance in the fibre. The mesoporous volume of the cotton fibre is higher than that of the modal fibre, while the micropore volume is the opposite. Consequently, DMC macromolecules, through free radical graft polymerisation, were more likely to diffuse into cotton fibres with more mesoporous content, increased the interaction force between anionic reactive dye and cotton fibre, and improved the dyeability of the cotton component and the union dyeing performance of the blended fabric.
Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature
Authors: Machado Isidro , Damaskou Vasileia , Ioannidis Eleftherios , Jour George , Linos Konstantinos 
Published: February 2024

AbstractCalcified chondroid mesenchymal neoplasm is a recently recognized bone and soft tissue entity primarily found in the extremities and the temporomandibular joint. This neoplasm is typically driven by the fusion of the FN1 gene with a kinase. In this case report, we provide a detailed account of a rare superficial calcified chondroid mesenchymal neoplasm located on the left big toe, characterized by an FN1::FGFR2 fusion. The tumor exhibited a peripheral collarette and consisted of large intradermal histiocytoid to epithelioid cells with no mitotic activity. These cells displayed fine chromatin and abundant pale eosinophilic cytoplasm, forming a swirling syncytium. They were interspersed with localized areas of glassy chondromyxoid matrix containing randomly mineralized calcific material and isolated osteoclast‐like giant cells. RNA sequencing confirmed the presence of an FN1 (exon 29)::FGFR2 (exon 7) gene fusion. Our report emphasizes the importance for dermatopathologists to consider this entity when evaluating superficial lesions displaying mesenchymal, chondroid, and calcified attributes.