bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient perspectives and barriers in the treatment of neovascular age-related macular degeneration in Denmark: a qualitative study
Authors: Thinggaard Benjamin Sommer , Pedersen Maria , Sorensen Torben Lykke , Grauslund Jakob , Stokholm Lonny 
Published: November 2023

ObjectivesThis qualitative study aims to identify patient-reported barriers to treatment for neovascular age-related macular degeneration (nAMD) and investigate their impact on quality of life.DesignUsing a qualitative explorative design.SettingSemi-structured individual or dyadic interviews were conducted with patients and their relatives.ParticipantsTwenty-one patients completed the interview, with four of them having a relative present.InterventionsGadamer’s hermeneutics guided the epistemological approach, and maximum variation sampling was employed to capture diverse patient experiences. An advisory board consisting of patients, relatives and ophthalmologists ensured the relevance of the study. Thematic analysis was conducted using NVivo software.Primary and secondary outcome measuresTo investigate patient-reported barriers to the recommended treatment for nAMD and impact on quality of life.ResultsThe study included 21 patients with nAMD, with a median age of 79 years. Five themes emerged: (1) good compliance with intravitreal treatment, (2) the dual role of relatives, (3) treatment commute, (4) hospital barriers, (5) preventive health literacy.ConclusionThis study highlights the resilience and adherence of patients with nAMD in Denmark to their treatment despite various barriers. While the therapy may have negative effects on their well-being, patients do not opt out of treatment. These findings underscore the importance of personalised treatment plans that provide, for example, convenient access to care and clear future agreements at the hospital. By adopting more patient-centred approaches, healthcare providers can enhance patient satisfaction and improve treatment adherence, ultimately leading to better patient outcomes and quality of life.
Exploratory Analysis of Factors Influencing Agile New Product Development Adoption in Manufacturing Industries
Authors: Palsodkar Manoj A. , Nagare Madhukar R. , Narwane Vaibhav S. 
Published: November 2023

Purpose: Global competition, individualized customer requirements, and volatile market conditions create an environment conducive to agile new product development (ANPD). This research seeks to identify the key factors that influence ANPD adoption along with the development of a conceptual framework for the identified factors. Design/methodology: Through a literature review, eight factors having 47 sub-factors pertinent to ANPD adoption and its performance improvement were identified. Considering all of these factors, the development of conceptual framework and research hypotheses was carried out. A structured questionnaire was used to collect 118 online responses from both domestic and foreign subject matter experts. The structural equation modeling (SEM) approach was used for validation of the conceptual framework along with the research hypotheses testing. Findings: This study supported six hypotheses: “Technology management competencies”, “Product development competencies”, “Organizational management competencies”, “Human resource competencies”, “Software management competencies”, and “Policy management competencies”. These supported hypotheses influence ANPD adoption significantly. However, the analysis did not support the two more positive factors, namely “Integrated system competencies” and “Supply chain competencies”, showcasing the necessity for a better understanding of them among the product development experts. Research limitations: As the proposed methodology relies on qualitative data, it is somewhat complex and time-consuming. While SEM can verify the linear relationship, a hybrid approach involving the SEM-MCDM technique can be employed to comprehend the impact of ANPD adoption and performance improvement. Practical implications: The findings of this study will assist product development experts, manufacturing executives, and managers in developing effective ANPD adoption policies. It will help in improving the new product development success rate and highlighting the causes of poor performance. Originality/value: This is a one-of-a-kind and highly beneficial structural modeling-based decision-making tool. This framework can be effective across multiple domains, and incidents of ANPD adoption failure can be mitigated.
DETERMINING THE ANTECEDENTS OF ENTREPRENEURIAL INTENTION AMONG UUM STUDENTS
Authors: MOHD YUSOF SITI NUR LIYANA BINTI , SULAIMAN SABIRAH , TANG MEI RUN 
Published: November 2023

This study delves into the intricate web of variables influencing entrepreneurial intentions among graduate students at Universiti Utara Malaysia (UUM). Despite a decline in Malaysia’s overall unemployment rate, the employability of graduates has emerged as a pressing concern. Ministry of Education reported in The Graduate Tracer Malaysia 2019 that a substantial 60% of Malaysian graduates remain unemployed a year post-graduation. In light of this context, the research identifies and examines five crucial antecedents that shape entrepreneurial intentions. Employing a comprehensive survey, each variable — knowledge, environment, subjective norm, attitude, perceived behavioral control, and entrepreneurial intention — is meticulously gauged using a 7-point interval scale. Employing the drop-off/pick-up method, 250 questionnaires were disseminated, yielding 206 completed responses. The collected data underwent rigorous analysis employing structural equation modeling (SEM) thru the application of AMOS 20 software. This paper not only presents the empirical findings but also engenders a nuanced discussion around them, thus paving the way for prospective directions of future study.
Assessment of Severity of Long QT Syndrome Phenotype and Risk of Fetal Death
Authors: Albertini Lisa , Ezekian Jordan , Care Melanie , Silversides Candice , Sermer Mathew , Gollob Michael H. , Spears Danna 
Published: November 2023

Background
It has been postulated that long QT syndrome (LQTS) can cause fetal loss through putative adverse effects of the channelopathy on placenta and myometrial function. The authors aimed to describe the fetal death rate in a population of pregnant women with long QT syndrome and investigate whether women with more severe phenotype had worse fetal outcomes.

Methods and Results

The authors retrospectively evaluated fetal outcomes of 64 pregnancies from 23 women with long QT syndrome followed during pregnancy in a tertiary pregnancy and heart disease program. Thirteen of 64 pregnancies (20%) resulted in a fetal loss, 12 miscarriages (19%), and 1 stillbirth (1.6%). Baseline maternal characteristics, including age and use of β‐blockers, did not differ between women who experienced a fetal death or not. Maternal corrected QT interval (QTc) was significantly longer in pregnancies that resulted in fetal death compared with live births (median, 518 ms [interquartile range (IQR), 482‐519 ms] versus 479 ms [IQR, 454–496 ms],
P
<0.001). Mothers treated with β‐blockers had babies born at term with lower birth weight compared with untreated women (2973±298 g versus 3470±338 g,
P
=0.002). In addition, the birth weight of babies born at term to treated women with QTc >500 ms was significantly lower compared with women with QTc <500 ms (2783±283 g versus 3084±256 g,
P
=0.029).

Conclusions
Women with long QT syndrome with more severe phenotypes have a higher incidence of fetal death. Maternal QTc is longer in pregnancies that result in fetal loss, and the birth weight of babies born to patients taking β‐blockers with a QTc >500 ms is lower, suggesting that patients with more marked phenotype may experience worse fetal outcomes.
Association Between Remote Monitoring and Interstage Morbidity and Death in Patients With Single‐Ventricle Heart Disease Across Socioeconomic Groups
Authors: Cherestal Bianca , Erickson Lori A. , Noel‐MacDonnell Janelle R. , Shirali Girish , Graue Hancock Hayley S. , Aly Doaa , Files Matthew , Clauss Sarah , Jayaram Natalie 
Published: November 2023

Background
Despite improvements in survival over time, the mortality rate for infants with single‐ventricle heart disease remains high. Infants of low socioeconomic status (SES) are particularly vulnerable. We sought to determine whether use of a novel remote monitoring program, the Cardiac High Acuity Monitoring Program, mitigates differences in outcomes by SES.

Methods and Results

Within the Cardiac High Acuity Monitoring Program, we identified 610 infants across 11 centers from 2014 to 2021. All enrolled families had access to a mobile application allowing for near‐instantaneous transfer of patient information to the care team. Patients were divided into SES tertiles on the basis of 6 variables relating to SES. Hierarchical logistic regression, adjusted for potential confounding characteristics, was used to determine the association between SES and death or transplant listing during the interstage period. Of 610 infants, 39 (6.4%) died or were listed for transplant. In unadjusted analysis, the rate of reaching the primary outcome between SES tertiles was similar (
P
=0.24). Even after multivariable adjustment, the odds of death or transplant listing were no different for those in the middle (odds ratio, 1.7 [95% CI, 0.73–3.94) or highest (odds ratio, 0.997 [95% CI, 0.30, 3.36]) SES tertile compared with patients in the lowest (overall
P
value 0.4).

Conclusions
In a large multicenter cohort of infants with single‐ventricle heart disease enrolled in a digital remote monitoring program during the interstage period, we found no difference in outcomes based on SES. Our study suggests that this novel technology could help mitigate differences in outcomes for this fragile population of patients.
Omics and Extreme Phenotyping Reveal Longitudinal Association Between Left Atrial Size and Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension
Authors: Kelly Neil J. , Newhouse David , Chapagain Himal , Patel Ashish , Tang Yicheng , Howard Ato , Kirillova Anna , Kim Hee‐Jung J. , Rahman Haris , El Khoury Wadih , Nouraie Seyed Mehdi , Hickey Gavin , Sade Leyla Elif , Jain Sandeep , Chan Stephen Y. 
Published: November 2023

Background
Left heart disease is the most common cause of pulmonary hypertension (PH) and is frequently accompanied by increases in pulmonary vascular resistance. However, the distinction between phenotypes of PH due to left heart disease with a normal or elevated pulmonary vascular resistance—isolated postcapillary PH (IpcPH) and combined pre‐ and postcapillary PH (CpcPH), respectively—has been incompletely defined using unbiased methods.

Methods and Results
Patients with extremes of IpcPH versus CpcPH were identified from a single‐center record of those who underwent right heart catheterization. Individuals with left ventricular ejection fraction <40% or with potential causes of PH beyond left heart disease were excluded. Medication usage in IpcPH and CpcPH was compared across Anatomical Therapeutic Chemical classes and identified vitamin K antagonists as the only medication with pharmacome‐wide significance, being more commonly used in CpcPH and for an indication of atrial fibrillation in ≈90% of instances. Accordingly, atrial fibrillation prevalence was significantly higher in CpcPH in a phenome‐wide analysis. Review of echocardiographic data most proximal to right heart catheterization revealed that left atrial diameter indexed to body surface area—known to be associated with atrial fibrillation—was increased in CpcPH regardless of the presence of atrial fibrillation. An independent cohort with serial right heart catheterizations and PH–left heart disease showed a significant positive correlation between change in left atrial diameter indexed to body surface area and change in pulmonary vascular resistance.

Conclusions
Guided by pharmacomic and phenomic screens in a rigorously phenotyped cohort, we identify a longitudinal association between left atrial diameter indexed to body surface area and pulmonary vascular resistance with implications for the future development of diagnostic, prognostic, and therapeutic tools.
Imaging Biomarkers and Prevalence of Complex Aortic Plaque in Cryptogenic Stroke: A Systematic Review
Authors: Sakai Yu , Cao Quy , Rubin Jeremy , Witsch Jens , Cohen‐Addad Dan , de Macedo Rodrigues Katyucia , Coco‐Martin Maria Begoña , Pasyar Pouyan , Juega Jesús , Fan Zhaoyang , Kasner Scott E. , Cucchiara Brett L. , Song Jae W. 
Published: November 2023

Background
Complex aortic plaque (CAP) is a potential embolic source in patients with cryptogenic stroke (CS). We review CAP imaging criteria for transesophageal echocardiogram (TEE), computed tomography angiography (CTA), and magnetic resonance imaging and calculate CAP prevalence in patients with acute CS.

Methods and Results

PubMed and EMBASE databases were searched up to December 2022 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guideline. Two independent reviewers extracted data on study design, imaging techniques, CAP criteria, and prevalence. The Cochrane Collaboration tool and Guideline for Reporting Reliability and Agreement Studies were used to assess risk of bias and reporting completeness, respectively. From 2293 studies, 45 were reviewed for CAP imaging biomarker criteria in patients with acute CS (N=37 TEE; N=9 CTA; N=6 magnetic resonance imaging). Most studies (74%) used ≥4 mm plaque thickness as the imaging criterion for CAP although ≥1 mm (N=1, CTA), ≥5 mm (N=5, TEE), and ≥6 mm (N=2, CTA) were also reported. Additional features included mobility, ulceration, thrombus, protrusions, and assessment of plaque composition. From 23 prospective studies, CAP was detected in 960 of 2778 patients with CS (0.32 [95% CI, 0.24–0.41],
I
2
=94%). By modality, prevalence estimates were 0.29 (95% CI, 0.20–0.40;
I
2
=95%) for TEE; 0.23 (95% CI, 0.15–0.34;
I
2
=87%) for CTA and 0.22 (95% CI, 0.06–0.54;
I
2
=92%) for magnetic resonance imaging.

Conclusions
TEE was commonly used to assess CAP in patients with CS. The most common CAP imaging biomarker was ≥4 mm plaque thickness. CAP was observed in one‐third of patients with acute CS. However, high study heterogeneity suggests a need for reproducible imaging methods.
Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B
Authors: Liman Thomas G. , Siegerink Bob , Piper Sophie , Catar Rusan , Moll Guido , Riemekasten Gabriela , Heidecke Harald , Heuschmann Peter U. , Elkind Mitchell S. V. , Dragun Duska , Endres Matthias 
Published: November 2023

Background
Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases. We investigated the impact of vasoregulatory autoantibodies on clinical outcome after ischemic stroke.

Methods and Results

Data were used from the
PROSCIS‐B
(Prospective Cohort With Incident Stroke–Berlin). Autoantibody‐targeting receptors such as angiotensin II type 1 receptor (AT1R), endothelin‐1 type A receptor, complement factor‐3 and ‐5 receptors, vascular endothelial growth factor receptor‐1 and ‐2, vascular endothelial growth factor A and factor B were measured. We explored associations of high antibody levels with (1) poor functional outcome defined as modified Rankin Scale >2 or Barthel Index <60 at 1 year after stroke, (2) Barthel Index scores over time using general estimating equations, and (3) secondary vascular events (recurrent stroke, myocardial infarction) or death up to 3 years using Cox proportional hazard models. We included 491 patients with ischemic stroke with data on autoantibody levels and outcome. In models adjusted for demographics and vascular risk factors, high autoantibody concentrations (quartile 4) targeting complement factor C3a receptor, vascular endothelial growth factor receptor‐2, and vascular endothelial growth factor B were associated with poor functional outcome at 1 year: (odds ratio, 2.0 [95% CI, 1.1–3.6]; odds ratio, 1.8 [95% CI, 1.1–3.2]; and odds ratio, 2.1 [95% CI, 1.2–3.6], respectively) and with lower Barthel Index scores over 3 years (complement factor C3a receptor: adjusted β=−3.3 [95% CI, −5.7 to −0.5]; VEGF‐B: adjusted β=−2.4 [95% CI, −4.8 to −0.06]). Patients with high autoantibody levels were not at higher risk for secondary vascular events or death.

Conclusions
High levels of autoantibodies against vascular endothelial growth factor receptor‐2, vascular endothelial growth factor B, and complement factor C3a receptor measured are associated with poor functional outcome after stroke but not with recurrent vascular events or death.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01363856.
Robust Collaterals Are Independently Associated With Excellent Recanalization in Patients With Large Vessel Occlusion Causing Acute Ischemic Stroke
Authors: Yedavalli Vivek , Koneru Manisha , Hoseinyazdi Meisam , Greene Cynthia , Copeland Karen , Xu Risheng , Luna Licia , Caplan Justin , Dmytriw Adam A. , Guenego Adrien , Heit Jeremy , Albers Gregory , Wintermark Max , Gonzalez Luis Fernando , Urrutia Victor , Huang Judy , Leigh Richard , Marsh Elisabeth , Llinas Rafael , Hillis Argye , Nael Kambiz 
Published: November 2023

Background
In patients with acute ischemic stroke secondary to large vessel occlusion, achieving modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 (excellent recanalization) over mTICI 2b is associated with improved functional outcomes. We aimed to determine pretreatment and interventional parameters that are independently associated with mTICI 2c/3 over 2b reperfusion in patients who underwent technically successful mechanical thrombectomy.

Methods
In this retrospective study, consecutive patients with acute ischemic stroke with anterior circulation large vessel occlusion achieving mTICI 2b/2c/3 recanalization after mechanical thrombectomy were included. We evaluated the association between pretreatment clinical, imaging, and interventional parameters in patients who achieved mTICI 2c/3 versus 2b using multivariate logistic regressions.

Results

From May 11, 2019 to October 9, 2022, 149 consecutive patients met our inclusion criteria (median 70 years old [interquartile range 65–78.5], 57.7% female). Adjusted multivariate regression analyses showed that patients with excellent recanalization had lower admission National Institutes of Health Stroke Scale scores (adjusted odds ratio [aOR], 0.93;
P
=0.036), were less likely to have a history of diabetes (aOR, 0.42;
P
=0.050) and prior stroke (aOR, 0.27;
P
=0.007), had a cerebral blood volume index ≥0.7 (aOR, 3.75;
P
=0.007), and were more likely to achieve excellent recanalization with aspiration alone (aOR, 2.89;
P
=0.012). A multivariate logistic regression model comprising these independent factors predicted mTICI 2c/3 with an area under the curve 0.79 (95% CI, 0.68–0.86;
P
<0.001), sensitivity of 94%, and specificity of 41%.

Conclusion
Robust collateral status defined by cerebral blood volume index ≥0.7 on pretreatment computed tomography perfusion, absence of prior stroke, and absence of diabetes are independently associated with excellent recanalization in patients with successfully recanalized acute ischemic stroke‐large vessel occlusion. Our findings highlight the prognostic implications of robust collateral status and modifiable risk factors that may influence collateral status for maximizing the likelihood of excellent recanalization.
Comparison of maps of species richness and endemism produced directly from species occurrences with those produced by stacked species distribution modelling
Authors: Volis Sergei , Tojibaev Komiljon 
Published: November 2023

Abstract
Knowledge of the spatial patterns of biodiversity is essential for identifying conservation hotspots. Two commonly used methods of biodiversity assessments are point-to-grid maps and habitat suitability maps generated by stacked species distribution modelling (S-SDM). We compared these two types of maps using three metrics: species richness, weighted endemism (WE), and corrected weighted endemism (CWE) produced for three monocot genera (Allium, Tulipa and Eremurus) in Uzbekistan. Also, we asked how close the patterns of species richness and weighted endemism predicted by S-SDM will be if the sampling density is significantly reduced. To answer this question, we compared the maps of species richness and WE produced using the entire dataset, with one in which species occurrences were thinned to no more than ten occurrences per species. The patterns of species richness and WE in point-to-grid maps and maps generated by S-SDM were very similar for all three genera. However, the spatial distribution of CWE generated by S-SDM was dramatically different from that of point-to-grid maps, and this difference was consistent across the three genera. For species richness and WE, the maps produced by S-SDM from the reduced and complete datasets were similar and close to the analogous point-to-grid maps. These results suggest that even incomplete surveys can provide valuable data for elucidating spatial biodiversity patterns and that for conservationists, S-SDM should be an essential part of their toolbox. However, the use of CWE in S-SDM applications should be avoided.
La notion de soi chez l’alcoolique : altérité et ipséité
Authors: Singaïny Erick Jean-Daniel 
Published: November 2023

Résumé
Pour parler vulgairement l’alcoolique a un problème avec le monde et avec l’altérité en raison de sa double figure : il est familier et étrange, toujours ailleurs. Autrement dit, c’est son problème d’identité ou le fait de « rester soi-même » (ipséité) qui est ici questionné car on ne doute pas qu’il est mais on ne sait plus ce qu’il est lorsqu’il boit. Le problème du soi chez l’alcoolique est un problème central lorsque nous envisageons le boire ou l’alcoolisme. Il sera abordé ici dans sa dimension anthropologique, philosophique et clinique. Nous verrons en chemin que nous serons confrontés à une forme de limite qui interroge la place du soignant et la notion de thérapeute. C’est de notre place de soignant que nous parlons.
The Struggle of Ukrainian Women for the Right to Higher Education: Historical and Philosophical Receptions of Liudmyla Smoliar
Authors: Karpenko Kateryna 
Published: November 2023

Abstract
The article examines the conceptualization of the struggle of Ukrainian women for the right to higher education by the Ukrainian historian Liudmyla Smoliar. In the book The Past for the Sake of the Future, she analyzed this topic in a socio-political and cultural context. The researcher noted that under the influence of the social movement of the early 1860s, women were allowed to study at the universities of Kyiv, Kharkiv, and Odesa. Achievements and victories of the pioneers of this field were interspersed with obstacles and new prohibitions. Economic dependence on parents, and then on husbands, outdated legal norms, and political discrimination forced women to look for ways of self-realization. Summarizing the circumstances in which women had to assert their right to education, the researcher concluded that women gradually achieved convincing success, overcoming numerous obstacles at each stage of the arduous struggle for their rights to higher education.