bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecology of emergency care in lower-tier healthcare providers in Ghana: an empirical data-driven Bayesian Network analytical approach
Authors: Afrifa-Yamoah Ebenezer , Nunfam Victor Fannam , Kwanin Bernard Agyei , Frimpong Kwasi 
Published: January 2024

Abstract

Introduction: The landscape of health system in Ghana is primarily composed of lower-tier providers, which are mostly the initial point of contact for most medical emergency cases. With the growing incidence of health emergencies, this study sought to provide a realist evaluation of the extent of emergency care preparedness and readiness of primary healthcare providers and empirically quantify the states of the emergency setups.
Method: A multicentre retrospective cross-sectional study design was employed to assess the emergency care preparedness of 460 lower-tier healthcare providers, using a standardised Health Facilities Emergency Preparedness Assessment Tool (HeFEPAT). Data were analysed via Bayesian Belief network using the software product GeNIe 4.0.
Results: Our study found associations between health facilities' emergency preparedness and location, facility type, ownership, and in-charge personnel. Specifically, more than 70% of the 460 facilities lacked specialised emergency/critical care personnel. Of the 460 in-charges surveyed, 297 (65.0%) reported protocol knowledge but only 36 (7.8%) could execute cardio-pulmonary resuscitation (CPR). 414 facilities 90.0% lacked onsite defibrillators. Over 80% of facilities reported no cerebrovascular accident medications available. Protocols for road traffic accidents were largely unavailable, even in public hospitals. The estimated probability that a given health facility would lack road traffic accident protocols was 0.53. Private facilities were more likely than government facilities to lack protocols for road traffic accidents (76% vs 20% probability) and general acute care (62% vs 32%).
Conclusion: Major emergency preparedness gaps were found across health facilities in this study, indicating inability to effectively handle critical situations like cardiac arrests or strokes. To improve public health and safety, urgent investments are needed in emergency medicine training, essential medications/equipment, and evidence-based protocols. Standardised emergency preparedness assessments policy should be formulated and implemented for accreditation and quality improvement. Further research can support developing national guidelines and targeted interventions to strengthen emergency response capacities.
Succinylation participates in the progress of Idiopathic pulmonary fibrosis through mitochondrial energy metabolism
Authors: Zhao Yunmulan , Hou Wenyu , Yang Liqing , Guo Lu , Wang Ping , Gao Lingyun , Xu Zuojun , Sun Wei 
Published: January 2024

Abstract

Background A new pathogenic role for mitochondrial dysfunction has been associated with aging and correlated with the development of idiopathic pulmonary fibrosis (IPF). The latest study found that the lysine succinylation (Ksucc) is involved in many energy metabolism pathways and affects the metabolic process in mitochondria, making this modification highly valuable for studying IPF related to mitochondrial dysfunction. We speculate Ksucc participate in IPF progression through mitochondrial energy metabolism pathway.
Methods We used liquid chromatography with tandem mass spectrometry (LC-MS/MS) to perform the first global profiling of Ksucc in lung tissues with IPF patients. The changes of candidate key proteins and Ksucc sites related to energy metabolism in IPF lung tissues were analyzed by using the clusters of orthologous groups of proteins (COG), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene ontology (GO). We then compared these proteins with those reported in the literature in normal lung tissues by parallel reaction monitoring (PRM).
Results We identified 1964 Ksucc sites in 628 proteins. 675 Ksucc sites in 124 proteins closely related to mitochondrial metabolism. We compared these proteins with those reported in the literature in normal lung tissues to identify differences in 119 proteins and Ksucc sites in mitochondria. 43 Ksucc sites in 27 proteins were associated with energy metabolism. There were differences in the expression of 4 Ksucc sites in 4 proteins between normal and IPF lung tissues.
Conclusion Our work expands the Ksucc database in IPF lung and suggested that mitochondrial energy metabolism is involved in the progression of IPF. Ksucc sites of proteins associated with mitochondrial energy metabolism can also serve as candidate molecules for future mechanism exploration and drug target selection in IPF.
Vibration simulation and analysis of high-speed railways sound barriers under different conditions of bolts loosening
Authors: Hu Shihui , Zhao Qian , Jiang Bolong , Tan Zhao , Qi Chunyu 
Published: January 2024

Abstract

The structural instability caused by the loosening of bolts of the sound barrier of high-speed railways has become an important reason affecting its safe use, but there is still a lack of basic research on the possible structural vibration of the sound barrier when the bolts are loosened. In this study, a finite element model of the sound barrier of high-speed railway was constructed, and the vibration mode simulation analysis under different bolt loosening conditions was carried out. The results show that the loosening of the bolts between the column and the concrete foundation will cause the vibration frequency of the overall structure of the sound barrier to change, induce new local mode shapes, and lead to the increase of vibration displacement at the top of the column. The results of this study will provide a reference for the structural health detection method of high-speed railway sound barrier in the future.
Safety and effectiveness of using Disposable Ultrasonic Shears to coagulate 5-7mm blood vessels: protocol for a prospective, multicenter, randomized, parallel controlled, non-inferiority clinical trial
Authors: Wang Xipeng , Li Chengqiang , Fan Junqiang , Hu Jian , Wang Mingsong , Li Hecheng 
Published: January 2024

Abstract

Background:
The ultrasonic scalpel is widely used during surgery. It is safe and effective to close the pulmonary artery branch vessels of 7 mm or below with an ultrasonic energy device as reported. However, there have been no multicenter randomized clinical trial to assess the safety and effectiveness of using ultrasonic scalpel to coagulate 5-7mm blood vessels in thoracic surgery.
Methods:
This is a prospective, multicenter, randomized, parallel controlled, non-inferiority clinical trial. A total of 144 eligible patients planning to undergo lung or esophageal surgery will be randomly allocated to the experimental group and the control group. The investigational product (Disposable Ultrasonic Shears manufactured by Reach Surgical, Inc.) and the control product (Harmonic Ace+7, 5mm Diameter Shears with Advanced Hemostasis) will be used in each group. The primary endpoint is the success rate of coagulating target blood vessels during surgery. Secondary endpoints include postoperative rebleeding, intraoperative bleeding volume, drainage volume, surgical duration, etc. Postoperative follow-up before and after discharge will be performed.
Discussion:
This clinical trial aims to evaluate the safety and effectiveness of using the investigational product (Disposable Ultrasonic Shears manufactured by Reach Surgical, Inc.) and that of the control product (Harmonic Ace+7, 5mm Diameter Shears with Advanced Hemostasis) to coagulate 5-7mm blood vessels in thoracic surgery.
Trial registration:
ClinicalTrials.gov: NCT06002737. The trial was prospectively registered on 16 August 2023, https://www.clinicaltrials.gov /study/NCT06002737.
Optimization of Dynamic Task Allocation forMulti-UAV Systems: Search and Rescue Scenario
Authors: Qamar Rahim Ali , Sarfraz Mubashar , Ghauri Sajjad Ahmed , Baig Noman Anwar , Cheema Tanweer Ahmad 
Published: January 2024

Abstract
Unmanned aerial vehicles (UAVs) are becomingincreasingly popular due to their versatility and cost-effectivenessand are used in various scenarios, such as sea exploration andsearch and rescue missions. Urban search and rescue requires aprompt and effective response to unforeseen events like faultsin UAVs, changes in task duration and deadline, new UAVarrivals, and task deletions. This paper extends the compromiseddynamic performance impact (CDPI) algorithm and introducesan enhanced CDPI (ECDPI) that can effectively handle dynamicevents during task execution. For dynamic event handling inthe ECDPI algorithm, the communication and conflict resolutionphase uses the time cost vector of each UAV for its assignedtask, as well as improvements in the detect dynamic activity function. In addition, limitations and cases against dynamicevents are discussed to exploit the proposed scheme effectively.The simulation results demonstrate that ECDPI is highly effectiveat handling dynamic events during the task execution phase
Light-chain Amyloidosis with Concomitant Symptomatic Myeloma (CRAB-SLiM Features): Clinical Characteristics, Cytogenetic Abnormalities, and Outcomes
Authors: Liu Peng , Yu Chenqi , Li Jing , Xu Tianhong , Wang Wenjing , Yang Yang , Zhou Chi , Wang Pu 
Published: January 2024

Abstract
Patients with light chain (AL) amyloidosis and concomitant symptomatic multiple myeloma (MM) are known to have a worse prognosis, while the prognostic implication of cytogenetic abnormalities (CA) and optimal treatment schemes are not well-established. This study retrospectively evaluated the clinical characteristics, CA, and outcomes of 106 patients with AL amyloidosis and concomitant symptomatic MM (MM-AL) by comparing with patients with MM (n=658) or primary AL amyloidosis (pAL, n=151) alone. The prevalence of t(11;14) was significantly higher in the pAL-alone group than in MM-AL and MM-alone group (40.7 % vs. 25.7% vs. 16.6%, p<0.001), and the prevalence of del13q, gain1q21 and high-risk CA (HRCA) decrease in turn in MM-alone, MM-AL and pAL-alone group. The progression-free survival (PFS) and overall survival (OS) of MM-AL patients (median, 12.8 and 25.2 months) were significantly inferior to patients with MM-alone and pAL-alone. No significant difference in PFS and OS was found between MM-AL patients with and without HRCA. When stratified by the type of plasma cell disease and status of t(11;14), patients with MM-AL and t(11;14) presented the worst OS (median, 8.2 months, p<0.001). Regarding the management of MM-AL, extended cycles of induction therapy and the use of maintenance therapy contributed to a better prognosis.
Raman spectroscopy analysis of 752 urinary stones comparison to Fourier Transform Infrared spectroscopy
Authors: LV Jianlin 
Published: January 2024

Abstract
Purpose. we employed Raman spectroscopy to analyze kidney stones compared the results with those obtained through FTIR spectroscopy to assess the reliability and accuracy of both techniques.
Material and methods February2019 to October 2023, a series of 752 stone samples was received at our center. The stones were obtained from spontaneous passage, SWL, URS and PCNL All stones were washed and dried. The stones were washed with deionized water to remove debris such as blood, mucus and gypsum. All samples were analyzed by 1064-nm Raman spectroscopy and IR. spectroscopy.
Results A total of 752 stone analyses were performed in this study. Most the stone samples have been found to be mixtures of two or three mineral components . 4.9% (n = 37) were pure stones, 47.2% (n =355) were composed of two components and 47.9% (n = 360) of three or more components. Besides, calcium salts were found in 86.4% (n = 650) of these stones, compared with 13.6% (n = 102) for non-calcium stones. Stones containing CaOx dominated in the whole series, with a proportion of 57.4%, followed by CA (28.9%), UA (6.3%), MAP (6.8%), Cystine (0.4%), and other stone constituents (0.2%).
Conclusions The findings of our study demonstrate the effectiveness of Raman spectroscopy in diagnosing kidney stones, making it a promising tool for future clinical applications. Raman spectroscopy offers easier operability, a better signal-to-noise ratio, and lower background, which enables results to be obtained quickly via automated analyses.
Emergence of the ocean CO2 uptake hole under global warming
Authors: Shin Yechul , Lee Huiji , Oh Ji-Hoon , Park So-Won , Kug Jong-Seong , Noh Kyung Min 
Published: January 2024

Abstract
Understanding the carbon cycle is crucial for an accurate assessment of emission allowances, which requires to mitigate climate change within the limits of human tolerance. The oceanic carbon system is an important reservoir for anthropogenic CO2 emissions, yet uncertainties persist regarding its future changes. Here, we employ the state-of-the-art model with different CO2 emission rates to systematically investigate the response of ocean CO2 uptake. We reveal the possibility of a pronounced weakening of the uptake–CO2 uptake hole–in the Subpolar North Atlantic (SPNA), where it is currently one of the most effective oceanic carbon sinks. Explosive accumulation of the surface dissolved inorganic carbon initiates the uptake hole, resulting from the collapse of local deep convection. The emergence of the uptake hole underscores the role of dynamical feedback in the carbon cycle, hence worthy of consideration in regional strategies for carbon dioxide removal.
Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study
Authors: Wang Shisong , Gao Hui , Lin Pengyao , Qian Tianchen , Xu Lei 
Published: January 2024

Abstract
Background and Aims
: Increasing evidences suggest that nonalcoholic fatty liver disease is associated with neuropsychiatric disorders. Nevertheless, whether there were causal associations between them remained vague. A causal association between neuropsychiatric disorders and NAFLD was investigated in this study.
Methods
We assessed the published genome-wide association study summary statistics for NAFLD, seven mental disorder-related diseases and five central nervous system dysfunction-related diseases. The causal relationship was first assessed using two-sample Mendelian randomization. Then, sensitivity analyses were performed, followed by a reverse MR analysis to determine whether reverse causality is possible. Finally, we performed replication analyses and combined the findings from the above studies.
Results
Our results showed NAFLD significantly increased the risk of anxiety disorders (OR = 1.016, 95% CI = 1.010–1.021, P value <0.0001). In addition, Major Depressive Disorder was the potential risk factor for NAFLD (OR = 1.233, 95% CI = 1.063–1.430, P value = 0.006). Furthermore, other neuropsychiatric disorders and NAFLD were not found to be causally related.
Conclusion
These results implied causal relationships of NAFLD with anxiety disorders and Major Depressive Disorder. This study highlighted the need to recognize and understand the connection between neuropsychiatric disorders and NAFLD to prevent the development of related diseases.
Utilizing daily excessive concentration hours to estimate small for gestational age infants attributable to fine particulate matter in Wuhan, China
Authors: Zhang Xiaowei , Zhu Shijie , Zhang Faxue , Zhao Gaichan , Zhang Xupeng , Zhu Wei , Li Dejia 
Published: January 2024

Abstract
Objectives
In China, there have been limited studies on the correlation between PM2.5 (fine particulate matter) and the occurrence of small for gestational age infants (SGA), and the majority of these studies have used the daily average concentration of PM2.5 as an exposure indicator. This study used daily excessive concentration hours (DECH) as a novel exposure measure to gauge the impact of PM2.5 on SGA in Wuhan.
Methods
Air pollutants and gravidae data are collected from the Wuhan Municipal Ecology and Environmental Bureau and Wuhan Children's Hospital, respectively. A logistic regression model was employed to evaluate the contributory impacts of PM2.5-DECH and PM2.5-mean on SGA.
Results
In this study, the notable correlations between PM2.5-mean and SGA were found during the second trimester [OR = 1.23 (95% CI: 1.14–1.32)] and the entire pregnancy [OR = 1.15 (95% CI: 1.07–1.24)]. This correlation was also observed between PM2.5-DECH and SGA in the second trimester [OR = 1.24 (95% CI: 1.16–1.34)] and the entire pregnancy [OR = 1.14 (95% CI: 1.06–1.22)]. No statistically meaningful disparities were observed among different subgroups in the analysis stratified by age, employment status, and education attainment. Through attribution analysis, we observed an approximate disease burden caused by PM2.5-mean and PM2.5-DECH.
Conclusions
Our study indicates that elevated levels of PM2.5 exposure are correlated with an elevated likelihood of SGA. In addition, this study indicates that DECH may be used as a prospective substitute indicator for daily average concentration to study the connection between PM2.5 and detrimental health impacts.
Cardiac Arrest During Liver Resection: two cases report
Authors: Shang Ziqing , Wang Yan , Weng Yan , Zhong Qing 
Published: January 2024

Abstract

Background
Patients with liver diseases often require surgery, and liver resection is a common surgical procedure. Intermittent Pringle Maneuver (IPM) is always used to control blood loss during liver resection surgery, but ischemia-reperfusion injury reduced by IPM will lead rapid change of internal environment, which will increase patients’ perioperative risk.
Case presentation
We reported a 59-year-old male and a 44-year-old male who underwent liver resection surgery for liver cancer and hepatolithiasis respectively. Cardiac arrest occurred during the procedure. Luckily, with high quality of cardiopulmonary resuscitation and electrical defibrillation, acidosis correction, as well as the treatment of lowering K+ and increasing Ca2+, they were rescued. The two patients recovered well without complication in 1-month followed-up.
Conclusion
In liver resection, the anesthesiologists need to pay close attention to the electrocardiography changes, especially at the moment of vascular opening during IPM. In addition, how to ensure the stability of patients’ internal environment during liver resection is an important clinical research work, which will provide evidence-based medical reference for anesthesiologists.
On B † - Splitting of Bounded Linear Operators on Ordered Hilbert space
Authors: Archana B. , Kurmayya T. 
Published: January 2024

Abstract

We discuss a subclass of a positive splitting called B † −splitting of bounded linear operator over ordered Hilbert spaces. The necessary conditions for the existence of such splitting is discussed by assuming the nonnegativity of Moore-Penrose inverse of operators. We refor-mulate a method to construct B † − splitting.
Mathematics subject classification(2020). 47B02, 47B65
A Multiobjective Evolutionary Approach to Solving Single-Allocation Hub Median Problem
Authors: Bhattacharjee Arup Kumar , Mukhopadhyay Anirban 
Published: January 2024

Abstract
This article presents a multiobjective formulation for the well-known Single-Allocation Hub Median Problem (MO-SA-H-MP). The objective of MO-SA-H-MP is to develop a three-level architecture consisting of demand nodes, hubs, and central hubs, for reducing transportation costs among nodes, while considering two objectives. The first objective is focused on reducing the overheads associated with hubs and central hubs, while the second objective is aimed at reducing transportation costs among nodes. The paper uses two approaches to solve MO-SA-H-MP. The first approach is based on the NSGA-II algorithm, while the second approach uses a Genetic Algorithm (GA) with a local refinement-based technique to solve each objective separately. The resultant network obtained from GA is applied to the other objective, and the solutions of both approaches are compared. The NSGA-II-based approach is found to perform equivalently to the exact method in 48.32% of cases, perform better than the indirect approach of solving each objective separately in more than 81.67% of cases, and have a deviation of less than 10% in 67.50% of cases from the direct approach for solving each objective separately using the Refined GA-based technique.
Supervillin-mediated ZO-1 downregulation facilitates migration of cisplatin-resistant HCT116 colorectal cancer cells
Authors: Hong Yali , Li Xu , Mao Rongchen , Zhou Feier , Jin Lai , Zhu Chao , Li Shengnan 
Published: January 2024

Abstract
Supervillin (SVIL), the biggest member of the villin/gelsolin superfamily, has recently been reported to promote the metastasis of hepatocellular carcinoma by stimulating epithelial-mesenchymal transition (EMT). However, data about the role of SVIL in the migration of colorectal cancer cells are scarce. We investigated the effects of SVIL on the migration of cisplatin-resistant colorectal cancer cells. The model of cisplatin-resistant HCT116 cells (HCT116/DDP) was established. SVIL-knockdown HCT116/DDP cells with virus infection were also used. Migration was assessed by transwell assay and wound healing assay, tumor metastasis was assessed using a mouse model with tail vein injection of colorectal cancer cells. The results showed that the expression of SVIL was upregulated in HCT116/DDP cells compared to their parental cells. Also, the HCT116/DDP cells showed increased cell migration, stemness and lung metastasis. Furthermore, we revealed that the up-regulated SVIL was associated with the induction of migration of HCT116/DDP cells. Reduced SVIL expression reversed the enhanced migration and lung metastasis in cisplatin-resistant colorectal cancer cells. Further work showed that SVIL silencing reduced cell migration by targeting zona occludens (ZO)-1 mediated tight-junction remodeling. The expression of ZO-1, but not occludin and cludin5, was down-regulated after SVIL knock-down. Fluorescence detection indicated that the linear ZO-1 expression was interrupted in HCT116/DDP cells while the SVIL silencing reversed the interruption. This study firstly displayed the relationship between SVIL and ZO-1 in cisplatin-resistant colon cancer cells, providing a new insight into the mechanism of colorectal cancer migration.