bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uji Aktivitas Antibakteri Ekstrak Jahe Merah (Zingiber officinale var. Rubrum) dan Ekstrak Bawang Putih (Allium sativum) terhadap Streptococcus pyogenes dengan Metode Difusi Cakram
Authors: Sitepu Jenny Novina 
Published: January 2024

ABSTRACT

Background: Infections and antimicrobial resistance remains a major public health worldwide. Therefore, studies regarding the natural therapeutic agent that is safe for humans and specific against bacteria are getting more interest.
Objective: This study aimed to investigate the effectiveness of combination red ginger and garlic extract against Streptococcus pyogenes.
Methods: This was a laboratory experimental study. The red ginger and garlic extract obtained by maceration extraction method using 70% ethanol and antibacterial activity test was conducted by disk diffusion method.
Results: : One way Anova test showed that red ginger extract in 75% and 100% concetrations have significant difference with the control. Garlic extract in 75% and 100% concentrations have significant difference with the control. The higher concentration result wider inhibition zona hambat both in red ginger and garlic extract. Otherwise, red ginger- garlic combination extract showed no significant difference with the control. The widest mean inhibitioin was shown in R50-G50 extract combination which is 2.45mm (±0.3). Post hoc LSD test showed that red ginger 100% that has significant difference with red ginger 25%, so did garlic extract. There was no significant difference between red ginger-garlic combination groups.
Conclusion: Red ginger and garlic extract has no synergic effect against Streptococcus pyogenes.
Hubungan Kadar Hemoglobin Glikosilat (HbA1c) dengan Kandidiasis Kutis pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Umum Daerah Dr. Pirngadi Medan Pada tahun 2019
Authors: Agatha Theresia Christin , Marpaung Okto , Sibarani Joseph 
Published: January 2024

Background: Cutaneous candidiasis is a fungal infection of the skin caused by yeast or microorganisms belonging to the genus Candida. It is known that diabetes mellitus is one of the predisposing factors for candidiasis cutis caused by changes in the body's defense system. Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion or insulin action. Starting from the autoimmune destruction of pancreatic cells resulting in insulin deficiency to abnormalities resulting in resistance to insulin action. To determine a person's level of glucose control, an HbA1c examination is needed. This test will show the average blood sugar level over the last 90 days and represent a percentage. This test can also be used to diagnose diabetes.
Objective: To analyze the relationship between HbA1c levels and cutaneous candidiasis in type 2 diabetes mellitus patients.
Methods: This study is an observational analytic study with a retrospective design. To determine the relationship between glycosylated hemoglobin (HbA1c) levels and cutaneous candidiasis in type 2 diabetes mellitus patients. On examination of HbA1c levels it can be said to be controlled < 6.5% and not controlled > 6.5%.
Results: The results of this study were taken from 62 patient medical record data according to the inclusion and exclusion criteria, it was found that the majority of patients with type 2 diabetes mellitus were women aged ≥55 years. Based on HbA1c levels, the patients in this study were more dominantly uncontrolled with negative cutaneous candidiasis, 56 (90.3%). The results of Fisher's exact analysis showed p-value = 1.000 (p > 0.05) meaning that there was no significant relationship between HbA1c levels and cutaneous candidiasis.
Conclusion: There is no significant relationship between HbA1c levels and the incidence of cutaneous candidiasis.
Persepsi Alumni terhadap Pencapaian Kurikulum Infeksi Tropis Fakultas Kedokteran Universitas HKBP Nommensen
Authors: Zaluchu Ristarin , Sitanggang Ervina Julien 
Published: January 2024

ABSTRACTS
Background: The perceived competence of newly graduated doctors who had undergone clinical practice in their first year could give insight into curriculum accomplishment.
Objective: This study aimed to understand alums' perceptions of their performance in tropical infection cases.
Methods: Alums who have finished their internship and have been practicing as doctors for less than a year were respondents to this study. We purposefully selected eight respondents based on gender, workplace, and work location. We conducted in-depth interviews by phone. The interview was recorded, and the conversation was transcribed verbatim. Thematic analysis is carried out on transcription by coding and categories.
Results: The interview results obtained two significant themes: the perception of competence related to tropical medicine cases and the perception of curriculum implementation. Cases and types of skills influenced perceptions of competence. Respondents perceived curriculum implementation as insufficient and influenced by case exposure, learning methods, and the national final exam.
Conclusion: Providing varied cases, improving feedback from clinical supervisors, and initiating early clinical experience are necessary to improve tropical infection competencies.
Keywords: perception, medical student, tropical infection
ABSTRAK
Latar belakang: Persepsi kompetensi alumni yang baru bekerja dapat memberikan informasi mengenai capaian kurikulum.
Tujuan: Penelitian ini bertujuan mendapatkan gambaran mengenai persepsi alumni terhadap kompetensinya dalam menghadapi kasus infeksi tropis.
Metode: Alumni yang sudah selesai menjalani internship dan telah berpraktek sebagai dokter kurang dari setahun menjadi responden dalam penelitian ini. Terdapat delapan responden yang dipilih dengan teknik purposive sampling, berdasarkan jenis kelamin, tempat kerja, dan lokasi kerja. Pengumpulan data dilakukan dengan wawancara mendalam menggunakan panggilan telepon. Hasil wawancara direkam dan ditranskripsi secara verbatim.Analisis tematik dilakukan terhadap transkripsi dengan cara membuat koding dan kategori.
Hasil: Hasil wawancara didapatkan dua tema besar yaitu persepsi kompetensi terkait kasus infeksi tropis dan persepsi mengenai implementasi kurikulum. Kasus dan jenis ketrampilan mempengaruhi persepsi mengenai kompetensi. Responden mempersepsikan implementasi kurikulum infeksi tropis masih kurang mencukupi. Persepsi ini dipengaruhi oleh paparan kasus, metode belajar, dan ujian kompetensi dokter.
Kesimpulan: Perbaikan metode pengajaran, memperbanyak kasus, serta umpan balik dari supervisor perlu untuk meningkatkan performa kompetensi kedokteran tropis.
Kata Kunci: persepsi; mahasiswa kedokteran; infeksi tropis
Optimalisasi Riset Hukum Berbasis Teknologi Informasi Pemasyarakatan
Authors: Soge Markus Marselinus , Rachmayanthy Rachmayanthy , Indahdewi Lauditta 
Published: January 2024

Hukum merupakan salah satu aspek kehidupan yang tidak dapat diabaikan, karena hukum melingkupi kehidupan manusia dalam perilaku kehidupan pribadinya maupun bermasyarakat bahkan bernegara. Dalam era teknologi informasi yang terus berkembang dengan cepat dan berbagai tantangan digital yang dihadapi, hukum terus mengikuti dinamika masyarakat. Penelitian ini bertujuan untuk mengetahui optimalisasi penelitian atau riset hukum berbasis teknologi informasi terkait Pemasyarakatan terhadap terpidana atau narapidana. Penelitian ini menggunakan metode penelitian hukum normatif dengan pendekatan perundang-undangan dan konseptual. Sumber data adalah data sekunder terutama bahan hukum primer berupa peraturan perundang-undangan dan bahan hukum sekunder, yang kemudian data tersebut dianalisis secara yuridis kualitatif. Hasil penelitian yakni optimalisasi riset hukum berbasis teknologi informasi Pemasyarakatan dapat dilakukan: a. dengan merujuk pada ketentuan Pasal 82 Undang-Undang Republik Indonesia Nomor 22 Tahun 2022 Tentang Pemasyarakatan, dan Peraturan Menteri Hukum Dan Hak Asasi Manusia Nomor 39 Tahun 2016 Tentang Sistem Database Pemasyarakatan, serta Peraturan Menteri Hukum Dan Hak Asasi Manusia Nomor 28 Tahun 2017 Tentang Perubahan Atas Peraturan Menteri Hukum Dan Hak Asasi Manusia Nomor 39 Tahun 2016 Tentang Sistem Database Pemasyarakatan; b. dengan menemukan informasi terkait Pemasyarakatan pada laman yang disediakan oleh Direktorat Jenderal Pemasyarakatan yakni laman Sistem Database Pemasyarakatan (SDP) Publik dengan alamat https://sdppublik.ditjenpas.go.id/.
The Efficacy of Levofloxacin-Based Triple Therapy over Standard ClarithromycinBased Therapy for Eradication of Helicobacter Pylori
Authors: Noor Haseeb , Virk Kazim Abbas , Abbasi Hyder Wajid , Virk Sana Tahir , Shahid Sara , Erfan Muhammad 
Published: January 2024

Objective: To compare a first-line Clarithromycin-based triple therapy to Levofloxacin-based triple therapy for eradicating H.Pylori.Study Design: Comparative analysis.Place and Duration of Study: The study was carried out at the Department of the Gastroenterology of Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan, from June 2021 to December 2021.Methods: A total of 200 patients were enrolled in this comparative study, conducted in the outpatient Department of Gastroenterology. A pretested questionnaire was used to gather the required information; a group was allocated to each patient, and a response was sent to each treatment group after random sampling. The primary outcome was a negative Urea Breath test 4 weeks after completion of treatment. Results: Out of 200 patients, 58 % (n=116) were males, and 39% (n= 84) were females. The mean age was 40.02 ± 24.4 years. Predominant presenting complaints were Retrosternal burning in 41 % (n=82), and pain and/or discomfort in the upper abdomen 34% (n=68). The response rate in the Clarithromycin based therapy group was 84% (n=84) out of 100 patients, while the response rate was 94% (n= 94) out of 100 in the Levofloxacin-based therapy group. Conclusion: Levofloxacin-based therapy is superior to Clarithromycin-based therapy in every age group and gender.How to cite this: Noor H, Virk KA, Abbasi HW, Virk ST, Shahid S, Erfan M. The Efficacy of Levofloxacin Based Triple Therapy over Standard Clarithromycin Based Therapy for Eradication of Helicobacter Pylori. Life and Science. 2024; 5(1): 61-67. doi: http://doi.org/10.37185/LnS.1.1.462
PHOTOGRAPHIC COLLECTION FROM N. ZHUKOVSKAYA’S (1874-1940) PERSONAL ARCHIVE IN THE COLLECTION OF THE LITERARY MUSEUM OF THE PUSHKIN HOUSE
Authors: Красильникова Дарья Сергеевна 
Published: January 2024

Данная статья представляет собой обзор и атрибуцию недавно выявленного архива фотоматериалов драматурга и переводчицы Натальи Юльевны Жуковской-Лисенко (1874-1940) в собрании Литературного музея Пушкинского Дома. Фотографии представляют собой портреты семей Жуковских, Ильиных и Лисенко. Особое внимание уделяется фотографиям, связанным с театральной деятельностью Натальи Юльевны, запечатлевшим сцены из театральных постановок и актеров, исполнявших роли в ее пьесах. Собрание писательницы позволяет ощутить ту театральную среду России конца XIX - начала XX веков.
This article is a review and attribution of a recently discovered archive of photographic materials of the playwright and translator Natalya Zhukovskaya-Lisenko (1874-1940) in the collection of the Literary Museum of the Pushkin House. The photographs present portraits of the Zhukovsky, Ilyin and Lisenko families. Particular attention is paid to photographs related to Natalya Yulievna’s theatrical activities, capturing scenes from theatrical productions and actors who performed roles in her plays. The writer’s collection allows you to feel the theatrical environment of Russia at the end of the 19th and beginning of the 20th centuries.
THE PHENOMENON OF REORIENTATION OF EDDY CURRENTS IN THE BLOOD STREAM UNDER THE INFLUENCE OF A CONSTANT INHOMOGENEOUS MAGNETIC FIELD
Authors: Захаров Юрий Борисович , Богатов Николай Маркович , Перов Юрий Митрофанович , Пыхалова Наталья Евгеньевна , Минасян Борис Леонович 
Published: January 2024

Вихревые токи, возникающие при убыли магнитного поля, способны особенно сильно приводить к обострению ишемической болезни сердца при ориентации магнитного поля вихревых токов вдоль оси кровеносного сосуда. При переходе от растущего магнитного поля к убывающему наблюдается явление переориентации направления вихревых токов.
Eddy currents arising from a decrease in the magnetic field can lead especially strongly to an exacerbation of coronary heart disease when the magnetic field of eddy currents is oriented along the axis of the blood vessel. During the transition from a growing magnetic field to a decreasing one, the phenomenon of reorientation of the direction of eddy currents is observed.
DESIGN OF WATER TANKS
Authors: Холодкова Ольга Владимировна , Помогаева Валентина Васильевна 
Published: January 2024

В статье приведены основные параметры резервуаров питьевой воды. Показаны направления решения выявленных проблем.
The article presents the main parameters of drinking water reservoirs. The directions of solving the identified problems are shown.
VALUE ORIENTATIONS AND SENSE OF SUBJECTIVE WELL - BEING IN STUDENTS
Authors: Сальникова Екатерина Петровна 
Published: January 2024

Представлены результаты исследования, направленного на выявление взаимосвязи субъективного благополучия и ценностных ориентаций у студентов. Выявлено, что имеется взаимосвязь ценностных ориентации и чувства субъективного благополучия; типов психологической защиты и чувства субъективного благополучия.
The results of a study aimed at identifying the relationship between subjective well-being and value orientations among students are presented. It was revealed that there is a relationship between value orientations and feelings of subjective well-being; types of psychological defense and feelings of subjective well-being.
RECOVERY OF MORAL DAMAGE FOR PROPERTY CRIMES IS A STEP TOWARDS HUMANIZATION IN FAVOR OF VICTIMS
Authors: Казакова Александра Викторовна 
Published: January 2024

В статье рассматривается вопрос о возмещении морального вреда жертвам имущественных преступлений; представляется, что дополнительная финансовая нагрузка на подсудимого положительным образом влияет на соблюдение баланса интересов в российском уголовном судопроизводстве. Без гуманизации судопроизводства в пользу потерпевших немыслимо развитие правового государства.
The article considers the issue of compensation for moral damage to victims of property crimes; it seems that the additional financial burden on the defendant has a positive effect on maintaining a balance of interests in Russian criminal proceedings. Without the humanization of legal proceedings in favor of victims, the development of a rule of law is unthinkable.
Desarrollo de un Algoritmo Procedimental de Generación de Estructuras para su Implementación en el Desarrollo de un Videojuego 2D
Authors: Acosta Guevara Lenin , Fernández Peña Félix 
Published: January 2024

Los algoritmos de generacion procedural con frecuencia son complejos y computacionalmente costosos. Con el presente trabajo, se propone un algoritmo de baja complejidad basado en pilas para producir una matriz de valores correlacionados aplicable al desarrollo de mapas de videojuegos 2D. La matriz resultante se interpreta como un mapa de altura, y mediante el ajuste de hiperparámetros, se pueden controlar características como la rugosidad o la topologia del mapa. La generación de geometría dentro de la matriz está esencialmente condicionada por el criterio que se defina para almacenar la información en la pila, implicando que es posible obtener diversos resultados aplicables a más de un género de videojuegos únicamente cambiando la forma en que se almacenan los nuevos datos. Algunos de los resultados incluyen geometría fractal semejante al fractal de caja, geometría arbórea al estilo L-System y cuevas semejantes a las que se obtendría con autómata celular. Finalmente se realizó una implementación en Godot Engine en un equipo de bajos recursos para generar dos tipos de mapas demostrando la aplicabilidad del algoritmo que se propone.
Is Post-COVID 19 Vaccination Antibody Level Related to Happiness and Stress Hormones?
Authors: UÇAR Cihat , DİŞLİ Faruk , ATÇALI Tuğçe , YILDIZ Sedat 
Published: January 2024

Aim: The level of antibody production in those vaccinated against coronavirus can be affected by many different situations. There is an important balance between immune response, stress and emotional state. However, it is not known how this situation affects antibody production after vaccination. This study aimed to investigate the correlation between the antibody response induced by the COVID-19 vaccine and the hormones cortisol, a marker of the stress axis, and serotonin, a marker of happiness.
Material and Method: Serum cortisol and serotonin levels were analyzed in those who tested positive (n=40) and negative (n=40) for Anti-SARS CoV-2 IgG induced by vaccination. Anti-SARS CoV 2 IgG, cortisol, and serotonin levels were determined by using the ELISA method. The data were compared using the Mann-Whitney U test. The value of p0.05).
Conclusion: Consequently, no effect of the stress parameter cortisol and the happiness parameter serotonin, was found in vaccine-induced immunization. It is considered that the different antibody responses in individuals may vary depending on other factors.
Investigation of Endoplasmic Reticulum Stress and Apoptosis Caused by Malachite Green-Mediated Sonodynamic Therapy in HL60 Cells
Authors: ÇALIŞKAN Metin , BAYRAK Gulsen , ÖZLEM ÇALIŞKAN Serçin 
Published: January 2024

Aim: Sonodynamic antitumor therapy is a promising, novel method for the treatment of cancer. To determine the effects of malachite green (MG) in the presence of ultrasound (US), MG was tested in vitro on HL60 cells at different concentrations as a sonodynamic compound. We investigated cell viability, morphology, and the occurrence of ER stress after MG-mediated sonodynamic therapy (SDT) in HL60 cells.
Aim: Sonodynamic antitumor therapy is a promising, novel method for the treatment of cancer. To determine the effects of malachite green (MG) in the presence of ultrasound (US), MG was tested in vitro on HL60 cells at different concentrations as a sonodynamic compound. We investigated cell viability, morphology, and the occurrence of endoplasmic reticulum (ER) stress after MG-mediated sonodynamic therapy (SDT) in HL60 cells.
Material and Method: Four groups were formed, including a control group, a group subjected to ultrasound (US) only, a group treated with various concentrations of MG, and a group treated with US using the same concentrations. The cells were treated with 1MHz ultrasound at 2 W/cm2 for 3 minutes. The assessment of cell viability was conducted 24 hours post-treatment through the utilization of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Cell morphology and apoptotic index were determined using Giemsa staining, while GRP78 and PERK expressions were determined through immunocytochemistry staining.
Results: The cell cytotoxicity of HL60 cells significantly increased after MG-mediated sonodynamic therapy. After treatment, apoptotic cells with micronuclei were observed morphologically. Significant levels of GRP78 and PERK expression were observed in all groups, except for PERK expression in the US group, compared to the control group.
Conclusion: The induction of ER stress, accompanied by intense apoptosis and a marked decrease in cell viability, demonstrates the potential of MG-mediated sonodynamic therapy in cancer treatment. Investigating ER stress as a molecular target may contribute to improving the treatment method.
Dexmedetomidine and Fentanyl in Endotracheal Intubation: A Comparative Analysis of Hemodynamic and Intubation Responses
Authors: TORUN GÖKTAŞ Ayşegül , TEMİZEL Feriha , ARSLAN Gülten , ÖZŞEKER Metin , SÜSLÜ Hüsnü , SAİTOĞLU Leyla 
Published: January 2024

Aim: Endotracheal intubation, a critical procedure in anaesthesia, can induce significant hemodynamic fluctuations, posing risks, especially to patients with cardiovascular concerns. This study compares the effects of dexmedetomidine and fentanyl, two agents commonly used to mitigate these responses, on endotracheal intubation conditions and associated hemodynamic changes.
Material and Method: Conducted at tertiary care training and research hospital, this study involved 60 patients aged 40-60, all classified American Society of Anesthesiologists (ASA) I-II, undergoing elective upper and lower extremity surgeries. Excluding patients with contraindicating conditions, the subjects were divided into two groups to receive either dexmedetomidine or fentanyl, along with propofol and vecuronium, for induction. Hemodynamic parameters were continuously monitored, and intubation conditions were assessed using the Cooper scoring system.
Results: The study found that both dexmedetomidine and fentanyl effectively stabilised hemodynamic parameters during intubation. However, the fentanyl group displayed significantly higher total scores on the Cooper intubation conditions scale, indicating more favourable conditions for endotracheal intubation in terms of ease and patient comfort.
Conclusion: While both dexmedetomidine and fentanyl are effective in maintaining hemodynamic stability during endotracheal intubation, fentanyl demonstrates a slight advantage in optimising intubation conditions. This distinction offers valuable insight for anesthesiologists in tailoring anaesthetic strategies and balancing patient safety with procedural efficiency in surgical settings.
Naming Scargills and Thatchers
Authors: James Michael 
Published: January 2024

Chapter Three turns from considering ideas regarding collectives to those of the individual, with particular attention to the two most recognisable and divisive figures of the miners’ strike 1984-5, Arthur Scargill and Margaret Thatcher. Through a consideration of the politics of naming, the chapter explores the ways in which Scargill and Thatcher are ‘constructed’ through various acts of naming in the poems. It argues that these acts reveal the means by which various actors attempt to control cultural narratives in regards to British labour politics and trade unions. The way the names of Scargill and Thatcher come to be manipulated and presented expose the constructed nature of our labour narratives. These constructions seek to silence alternative voices and control the way labour narratives are received and understood. By controlling labour narratives, there is also an attempt to control the responses to our labour histories and labour presents.
Translating Marginalities: Staging Linguistic Diversity in the Comedia
Authors: Muñoz Laura , Muñoz Laura 
Published: January 2024

While translation is always a fraught exercise, translating the linguistic diversity present in some comedias can be a particularly daunting task, for the translation of early modern marginality can all too easily become entangled with modern stereotypes of communities currently underrepresented on the stage. This chapter takes two characters in plays translated by members of the UCLA Working Group, Pierres from Guillén de Castro’s Unhappily Married in Valencia (Los mal casados de Valencia) and Alcuzcuz from To Love Beyond Deathas case studies for issues underlying the translating and staging plurilingual characters from the comedia. Though Pierres and Alcuzcuz are representative of very different kinds of marginalities, in both cases performances of these translations have exposed the delicate balancing act of creating a translation which captures the plurality of languages and speakers which existed in the early modern period, and the danger these—often comic—characters have with becoming racialized caricatures of modern marginal communities.