bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolutionary patterns and heterogeneity of Dengue Virus serotypes in Pakistan
Authors: Mumtaz Zilwa , Saif Rashid , Yousaf Muhammad Zubair 
Published: October 2023

Abstract

Comprehensive and systematic examination of Dengue virus (DENV) evolution is essential in the context of Pakistan as the virus presents a significant public health challenge with the ability to adapt and evolve. To shed light on intricate evolutionary patterns of all four DENV serotypes, we analyzed complete genome sequences (n = 43) and envelope (E) gene sequences (n = 44) of all four DENV serotypes collected in Pakistan from 1994 to 2023 providing a holistic view of their genetic evolution. Our findings revealed that all four serotypes of DENV co-circulate in Pakistan with a close evolutionary relationship between DENV-1 and DENV-3. Genetically distinct serotypes DENV-2 and DENV-4 indicate that DENV–4 stands out as the most genetically different, while DENV-2 exhibits greater complexity due to the presence of multiple genotypes and the possibility of temporal fluctuations in genotype prevalence. Selective pressure analysis in Envelope (E) gene revealed heterogeneity among sequences (n = 44) highlighting 46 codons in the genome experiencing selective pressure, characterized by a bias towards balancing selection indicating genetic stability of the virus. Furthermore, our study suggested an intriguing evolutionary shift of DENV-4 towards the DENV-2 clade, potentially influenced by antibodies with cross-reactivity to multiple serotypes providing a critical insight into the complex factors shaping DENV evolution and contributing to the emergence of new serotype.
Rice Farmers’ Levels of Information Source on Mitigation Actions Against Climate Change Effects in North-East Zone, Nigeria
Authors: Malabe K. M. , Ango A. K. 
Published: October 2023

Abstract
This study assessed rice farmers’ levels of information source on mitigation actions against climate change effects in North-east zone Nigeria. Multi-stage random sampling techniques was employed to select 300 rice farmers. Data for this study were collected through primary and secondary sources. The analytical tools used in this study were descriptive (frequency count, percentages and weighted mean). The results of the socioeconomic shows that most 33% of the respondents fell within the age brackets of 47-54 with a mean age of 47.83 years. Majority 98.7% of the respondents were males, while 85.6% were married. More than half 54.7% fell within the ranges 7-11 household size. Their farming experience fell within 18-24 years with a mean farming experience of 17.15 years More than half 53.7% had no formal education. Majority (95.3) of the rice have not used mitigation actions against climate change effects. Also, level of information sources on mitigation actions and climate change effects were low and fell within the mean range of 1.0-1.70 level. Furthermore, socioeconomic characteristics significantly influence the use of mitigation actions among rice farmers. Based on the findings of this study it is concluded that majority of the rice farmers lack adequate level of information on mitigation actions and climate change effects from the sources saddle with the responsibility for providing information. Therefore, it is recommended that sources charge with the responsibility for providing information on mitigation actions and climate change effects should adequately live up to their obligations to provide farmers with useful information regarding climate related issues.
Comprehensive Pan-cancer Analysis of Cuproptosis-related Gene SLC31A1 as a Potential Biomarker for Cancer Survival and Immunotherapy
Authors: Li Huaixu , Gao Peng , Tian Haotian , Nie Jianyu , Dai Xingliang , Cheng Hongwei 
Published: October 2023

Abstract
Background
SLC31A1 is a cuproptosis-related gene associated with glucose metabolism in tumor cells. SLC31A1 has been linked to many different tumors in research, although no pan-cancer analysis has been conducted. This study set out to look into the connection between SLC31A1 and various malignancies.
Methods
The TCGA, GEPIA2, and cBioPortal databases were used to examine the expression of SLC31A1 and its association with prognosis in cancer. The association of SLC31A1 expression with several cancer-associated signaling pathways was further analyzed using single-cell sequencing. Finally, the functions significantly involved in SLC31A1 were investigated by immune infiltration analysis, correlation analysis of immune checkpoints, TMB and MSI, and GSEA enrichment analysis.
Results
SLC31A1 is substantially related to microsatellite instability (MSI) and tumor mutation load (TMB), indicating a positive immunotherapy response. It is also overexpressed in LGG when contrasted with standard samples. Single-cell sequencing and GSEA enrichment analysis showed that SLC31A1 is closely associated with a variety of cancer-related signaling pathways.
Conclusion
These findings serve to clarify the role of SLC31A1 in carcinogenesis from a variety of angles by showing a relationship between SLC31A1 expression and clinical outcome, DNA methylation, genetic mutations, and inflammatory cell infiltration. SLC31A1 could therefore be diagnostic for immunological and predictive aspects of many malignancies.
Survey of Compressive Sensing Techniques Based on Secure Date Aggregation in WSNs
Authors: madkour marwa , Soliman S. E. , Dessouky M. I. , El-Samie F. E. Abd , Elsafrawey A. S. , hammad M.E. 
Published: October 2023

Abstract

A key function of wireless sensor networks (WSN) is data collection. Due to the hot spot issue and the limited energy supply, developing data gathering techniques is complicated. The WSN faces three main challenges: security, data routing, and processing a lot of data. Since compressive sensing can achieve simultaneous sampling and compression, it is widely used in signal processing technique. Due to resource limitations and computational limitations, WSN security solutions are different from those in traditional networks. Compressive sensing (CS) and Elliptical curve Diffie-Hellman key exchange are used to solve these problems. The measurement matrix is configured to be as a public key that is understood by both the sensor node and the base station in order to achieve high safety and efficiency for data gathering in wireless sensor networks. Security and effective data collecting are the main study goals. A prime-numbered address strategy for TPID (tree path identifier) routing and cluster head selection is used. Comparison between seven types of CS algorithms is introduced over different data sparsity levels. The network parameters is being tested are Network life time, throughput, residual node energy and total energy dissipated. The results revels that the compression system can reduce the size of the transmitted data and consequently the energy consumption while still maintains the data security.
Fixed-Time Consensus of Multi-Agent System with Delayed Intermittent Control
Authors: Mwanandiye Eric S. 
Published: October 2023

Abstract
This paper investigates fixed-time consensus of delay multi-agent system with intermittent delay control. The delayed system is transformed into a system without delay by employing an Artstein’s reducing transformation method. The proposed nonlinear control can achieve fixed-time consensus in which upper bound settling time depends on design parameters and the time-delay. This makes it possible to determine settling time offline regardless of initial condition.
Extensive evaluation of image classifiers' interpretations
Authors: Poštić Suraja , Subašić Marko 
Published: October 2023

Abstract

The application of artificial intelligence in delicate fields has led to the increased popularity of deep model interpretation. When dealing with an image classification problem, interpretations are usually presented as two-dimensional saliency maps. Locations with the highest intensity are considered to be the most important for making a decision. Measuring the quality of the interpretations is challenging since humans do not understand the behavior of deep models. The biggest misconception is mistaking interpretation for weakly supervised object localization, which has reflected on the choice of the assessment metrics as well. This paper presents a carefully designed experimental procedure along with a set of quantitative interpretability assessment metrics that rely solely on the original model behavior. Previously noticed biases have been attenuated by treating locations with high and low intensity separately, considering the entire saliency maps, not just their positive values, and using classifiers with both high and low accuracy as well as all the classes in the dataset. The proposed assessment metrics were used to compare and analyze seven well-known interpretability methods on four image datasets. Even though they are ignored by some assessment metrics, our experiments show that negative saliency map values are just as important as the positive ones. DeepLIFT, Gradients X Inputs, and FullGrad achieved the best results. In contrast, Grad-CAM and Ablation-CAM have demonstrated some undesirable behaviors.
Lean Design-for-X Framework applied in the Crashworthiness and Environmental Design Assessment of a redesigned Passenger Coach
Authors: Lopes Rogério F. F. , Pinto Sara M. , Parente Marco P. L. , Moreira Pedro M. G. P. , Baptista A. J. 
Published: October 2023

AbstractA comprehensive crashworthiness analysis in the design of coaches, specifically focusing on adapting the ECE R29 standard, was made. The external fiberglass composite panels of two coach models were tested for replacement with a state-of-the-art polymer (DCPD). The analysis was based on the finite element method, using the software Pamcrash®, which evaluates the energy absorption capacity of the models, comparing deformation, displacements, and material penetration values over time. The assessment of the driver's residual space, as specified by the ECE R29 standard, is also included in the analysis. The Lean Design for eXcellence (LeanDfX) methodology was used, which involves multiple domains of analysis including model optimization, manufacturing process, and eco-design. It employs an index on a 0%-100% scale, to compare different 'X' domains, such as energy absorption capacity and material intrusion. An Eco-Design X study is also conducted to assess the environmental impacts of the proposed solution compared to the original models. Quantification is carried out using the Simapro v9.2.0.2 software with the ReCiPe 2016 methodology. The modifications proposed to the coach models are shown to result in significant improvement in the structural behaviour of the vehicle for driver's physical integrity in frontal impact scenarios. The cross results of Design-for-Crashworthiness and Design-for-Eco-Design using the LeanDfX framework provide a new perspective to be integrated in the automotive industry. The use of a state-of-the-art polymer (DCPD) for the external panels, is expected to lead to a more crashworthy and environmentally friendly design for coaches, while ensuring passenger safety.
The generalized core-EP inverses involvoing projections in Banach *- algebra
Authors: Chen Huanyin , Abdolyousefi Marjan Sheibani 
Published: October 2023

Abstract
We investigate necessary and sufficient conditions under which the differences and products of two projections are generalized core-EP in-vertible. Then we present the representation of generalized core-EP inverse in a Banach *-algebra element by using related projections. Moreover, ex-pressions involving projections for the generalized core-EP inverse are given in a symmetric Banach *-algebra.
Efficacy of Socket Shield Technique for Immediate Implant Placement in Maxillary Anterior Region – A Case Series with Review.
Authors: Taraphdar Sreetama , Sarkar Aniket 
Published: October 2023

The socket-shield technique is the most crucial treatment modality for esthetic enhancement and ridge preservation technique but it has been less discussed and documented. This case series describes the placement of implants immediately following extraction of a non-restorable which are all fractured and hopeless maxillary teeth and using this technique and functional and esthetic outcomes of the treatment was a successful event.
In this review, immediate implant were placed using socket shield protocol to treat ten patients with non-restorable teeth. Dissection was performed along the long axis of the roots in a mesiodistal direction; and atraumatically the buccal fragment of the root was left attached to the bone while the palatal fragment was extracted. Implants were placed after sequential osteotomy drilling. A customized healing abutment was fabricated chairside to create an emergence profile. During the prosthetic phase, patients had follow-up visits after 4 weeks and after 6 months. The definitive prosthesis was cemented using a cement-retained porcelain fused to metal.
Synthesis of Tetrahydrobenzo[b]pyrans Catalyzed by 1,3-Dibenzyl-1H-benzo[d]
imidazole-3-ium Chloride
Authors: Delfani Ali Moradi , Kiyani Hamzeh , Zamani Mehdi 
Published: October 2023

Abstract:
Tetrahydrobenzo[b]pyrans are fused oxygen-containing heterocycles that are found in many biologically
active compounds. Therefore, researchers in organic synthesis are searching for suitable, efficient, and
useful methods for their synthesis. In this contribution, a series of tetrahydrobenzo[b]pyran derivatives was synthesized
using aryl aldehydes, malononitrile, and cyclohexane-1,3-dione or dimedone as the available starting
materials. The three-component reactions were catalyzed by 1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride
as the N-heterocyclic carbene precursor. The heterocyclic oxygen-containing products were obtained in good to
excellent isolated yields within relatively shorter reaction times. Optimizing the reaction conditions was performed
from the point of view of various parameters of the reaction. The results of these experiments showed
that the best solvent system includes water-ethanol, the most suitable reaction temperature is 60ºC, and the optimal
amount of the imidazolium catalyst loading is 5 mol%. Operational simplicity, no need for chromatographic
methods for purification, simple work-up for pure products, and avoiding hazardous solvents are remarkable
features of this three-component reaction. Moreover, in these multicomponent cyclo-condensations,
no by-products were observed.
Optimizing the Extraction of Polyphenols from the Bark of Terminalia arjuna and an In-silico Investigation on its Activity in Colorectal Cancer
Authors: Adhikary Tathagata , Basak Piyali 
Published: October 2023

Background:
The interconnection between different fields of research has gained interest
due to its cutting-edge perspectives in solving scientific problems. Terminalia arjuna is indigenously
used in India for curing several diseases, and its pharmacological activities are being
revisited in recent drug-repurposing research.

Objective:
Efficient ultrasound-assisted extraction of phytochemicals from the bark of Terminalia
arjuna is highlighted in this study. Following the optimization of the extraction process, the
crude hydroethanolic extract is subjected to phytochemical profiling and an in-silico investigation
of its anti-cancer properties.

Materials and Methods:
A three-level four-factor Box-Behnken design is exploited to optimize
four operational parameters, namely extraction time, ultrasonic power, ethanol concentration (as
the extracting solvent) and solute (in g): solvent (in mL) ratio. At the optimum parametric condition,
the crude extract is obtained, and its GC-MS analysis is carried out. An analysis of network
pharmacology (by constructing and visualizing biological networks using Cytoscape) combined
with molecular docking reveals the potential antineoplastic targets of the crude extract.

Results:
The ANOVA table exhibits the significance, adequacy and reliability of the proposed
second-order polynomial model with the R² value of 0.917 and adjusted R² of 0.865. Experimental
results portray the significant antioxidant potential of the prepared extract in its crude
form. The GC-MS analysis of the crude extract predicts the extracted phytochemicals, while the
constructed biological networks highlight its multi-targeted activity in colorectal cancer

Conclusion:
The study identifies three phytochemicals viz. luteolin, β-sitosterol and arjunic acid
as potent anti-cancer agents and can be extended with in-vitro and in-vivo experiments to validate
the in-silico results, thus establishing lead phytochemicals in multi-targeted colorectal cancer
therapies.
REHABILITATION APPROACHES TO ADOLESCENT IDIOPATHIC SCOLIOSIS IN INTERNATIONAL PRACTICE
Authors: Bakaliuk T.H. , Rozheliuk O.V. , Panasiuk Ya.V. , Stelmakh H.O. , Makarchuk N.R. 
Published: October 2023

Актуальним завданням є вивчення сучасних підходів до використання фізичної терапії для лікування сколіотичної хвороби у підлітків з метою визначення ефективних методів, які мають належну наукову підтримку та доказову основу. Мета дослідження полягає в пошуку сучасних підходів до використання фізичної терапії у підлітків з сколіозом для визначення ефективних науково підтверджених методик консервативного лікування сколіозу та світових тенденцій у цьому напрямку.
В статті проведений аналіз реабілітаційних підходів, які використовуються у пацієнтів з підлітковим ідіопатичним сколіозом (ПІС) у міжнародній медичній практиці. Розглянуті актуальні методи та стратегії, спрямовані на поліпшення фізичного стану, якість життя та зменшення деформації хребта у підлітків з сколіозом.
Був проведений аналіз наукових статей, опублікованих в PubMed та Google Scholar з 2012 по 2022 рік, що стосувалися методів фізичної терапії для сколіотичної хвороби у підлітків.
Згідно з Оксфордським центром доказової медицини, фізіотерапевтичні специфічні вправи для лікування сколіозу (Physiotherapeutic Scoliosis Specific Exircises (PSSE)) можуть бути рекомендовані як перші заходи для запобігання прогресуванню сколіозу. Якщо PSSE не допомагають запобігти прогресуванню, рекомендується застосовувати корегуюче ортезування (тривимірний корсет Шено). У випадках, коли консервативне лікування не зупиняє прогресування сколіозу, може бути прийняте рішення про проведення оперативного втручання.
Всі науково обґрунтовані методики фізичної терапії для лікування сколіозу базуються на використанні фізіотерапевтичних специфічних вправ, які враховують зміни в трьох площинах.
Виходячи з аналізу публікацій, зроблено висновки про важливість інтегрованого підходу до реабілітації підлітків з ідіопатичним сколіозом та необхідність подальших досліджень для вдосконалення методів та підтвердження їхньої ефективності.
Ключові слова: підлітковий ідіопатичний сколіоз, фізична терапія, реабілітація
EFFECTIVENESS OF THE USE OF NORDIC WALKING IN PATIENTS AFTER CHOLECYSTECTOMY AT THE LONG-TERM STAGE OF REHABILITATION
Authors: Golod N.R. 
Published: October 2023

Мета дослідження – визначити ефективність застосування скандинавської ходьби (СХ) у пацієнтів після холецистектомії на довготривалому етапі реабілітації.
Матеріали і методи У дослідження включено 79 пацієнток після лапароскопічної холецистектомії на довготривалому етапі реабілітації.
Методи: Просте рандомізоване дослідження із засліпленням оцінювачів. Оцінювали 6-ти хвилинний тест ходьби, Модифіковану Шкала Борга, частоту серцевих скорочень (ЧСС), артеріальний систолічний тиск (САТ) артеріальний, діастолічний тиск ДАТ. Використовували СХ як засіб фізичної терапії. Методи математичної статистики: Вірогідність розходжень оцінювали за допомогою парного t-критерію Стъюдента для залежних вибірок. Розходження вважали статистично достовірними при р<0,05.
Результати В обох групах при первинному обстеженні виявлено підвищення рівнів систолічного, діастолічного артеріального тиску, підвищення ЧСС у стані спокою, зниженя від норми показники 6-ти хвилинного тесту ходьби та наявності відчуття задишки при виконанні тесту. При проведенні заключного обстеження було виявлено статистично достовірне (< 0,05) покращення показників у групі Б у порівнянні із групою А та у порівнянні із результатом первинного обстеження, а саме: параметрів 6-ти хвилинного тесту ходьби, у зменшенні відчуття задишки при ходьбі за Модифікованою Шкалою Борга, у зменшенні ЧСС, САТ та ДАТ у стані спокою.
Висновки Методика реабілітаційного втручання із застосуванням фізичної терапії у групі В, яка включала у себе скандинавську ходьбу є більш ефективною для збільшення толерантності до фізичного навантаження.
ENSINO POR COMPETÊNCIA
Authors: Oliveira Tarcisio Dorn de , Johann Diane Meri Weiller , Souza Matheus Cargnelutti de , Soares Igor Norbert 
Published: October 2023

Ensinar por competência traz consigo uma construção de conhecimento pessoal e singular, ao passo que, torna-se única e, tão somente, do sujeito, pois emerge quando, por meio de determinada circunstância. Considerando os procedimentos, metodologicamente, o artigo estrutura-se por uma revisão bibliográfica, pesquisa documental e relato de estudo de caso, tendo como objetivo apresentar e refletir uma intervenção artística, desenvolvida por estudantes do Curso de Arquitetura e Urbanismo da Universidade Regional do Noroeste do Estado do Rio Grande do Sul (UNIJUÍ) na Estação Cidadania Cultura e Esporte (ECCE), espaço este, que integra o Parque Popular da Pedreira de Ijuí/RS. Torna-se evidente que o ensino por competência deve ser traduzido na habilidade do estudante em estar apto a articular, relacionar e desenvolver, de forma conjunta, diversos saberes, conhecimentos, atitudes e valores por meio de ações cognitivas, afetivas e sociais sendo capaz de reconhecer-se na ambiência que o rodeia.