bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post delivery withdrawal time of tenofovir for blocking mother to child transmission of HBV in women with high HBV load during late pregnancy
Authors: Bai Na , Zhang Yingmei , Yang Ming , Gao Yuan , Yang Ruijia , Zhu Chunyan , Bai Yunhui , Shi Wei 
Published: January 2024

Purpose: To study the withdrawal time of tenofovir disoproxil fumarate (TDF) after delivery in parturient women having high hepatitis B virus (HBV) load who took TDF during late pregnancy to block fetal contact with HBV.
Methods: This is a retrospective analysis of clinical data of 77 pregnant women close to parturition with high HBV density in Southern Central Hospital of Yunan Province from February 2020 to February 2021. Based on time of drug discontinuation, they were assigned to group A (immediately after delivery, n = 24); group B (1 month after delivery, n = 26), and group C (3 months after delivery, n = 27). All three groups took TDF before delivery. Liver function, with alanine aminotransferase (ALT) was assessed using Roche detection system. Deoxyribonucleic acid of hepatitis B virus (HBV-DNA) was assayed by fluorescence quantitative method. Hepatitis B surface antigen (HBsAg) and HB e antigen (HBeAg) were measured using chemiluminescence microparticle immunoassay (CMIA). All assays were done after 2, 4, 8, 12, 18 and 24 weeks of drug withdrawal.
Results: All parameters in the three groups of patients returned to normal levels after 2, 4, 8, 12, 18 and 24 weeks of drug withdrawal. In 83 neonates, tests for hepatitis B DNA and surface antigen were negative 1 month after birth, with 100 % block of maternal neonatal transmission, and no HBV infection. The incidence of adverse reactions in pregnant women were 16.67, 19.24 and 18.52 % in groups A, B and C, respectively, with no significant difference (p > 0.05).
Conclusion: The therapeutic effect of TDF for parturient women with high HBV density is not related to drug withdrawal time after delivery. It is necessary to increase the number of samples in subsequent studies in order to validate the research results.
Effect of up-regulation of micro-ribonucleic acid-22 and NLRP3 inhibition on viability of malignant melanoma cells
Authors: Tian Jieli , Liu Li , Luo Wen 
Published: January 2024

Purpose: To determine the effect of up-regulation of micro-ribonucleic acid-22 (miR-22) targeting nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) on the proliferation and invasiveness of malignant melanoma cells, as well as the underlying mechanisms.
Methods: Mouse-derived melanoma B16 cells were subjected to thawing, sub-culture and transfection. The cells were assigned to groups (A1 - A5) in line with different transfections viz: A1 (miR-22 mimic overexpression-transfected), A2 (miR-22 inhibitor-transfected), A3 (miR-22 mimic+siNLRP3-transfected), A4 (miR-22 mimic NC sequence-transfected), and A5 (un-transfected).
Results: The miR-22 expression was significantly up-regulated in A1, relative to A2, A3, A4, and A5 groups, but significantly lower, relative to A3, A4, and A5. The NLRP3 mRNA and protein levels were significantly lower in A1 than in other groups, but significantly up-regulated in A2, relative to A3, A4, and A5 (p < 0.05). Cell proliferation rate and colony formation rate were significantly lower in A1 group but were significantly up-regulated in A2, relative to A3, A4, and A5.
Conclusion: Targeting NLRP3 inhibition by up-regulating miR-22 expression level significantly reduces the proliferation, invasiveness, and matrix metalloproteinase levels of melanoma B16 cells, thereby reducing the occurrence and development of malignant melanoma. The results provide some useful reference data for the treatment of malignant melanoma at the gene level.
Effect and mechanism of action of botulinum toxin type A on hypertrophic scar <i>in vitro</i>
Authors: Ma Juan , Dong Xianglin , Zhang Bo 
Published: January 2024

Purpose: To examine the effect of botulinum toxin type A (BTXA) on the formation of hypertrophic scar and to unravel its mechanism of action.
Methods: HSF cells were isolated from hypertrophic scars and cultured. Immunohistochemistry (IHC) assays were performed to determine TGF-β1, FN, and Col1 expressions in hypertrophic scar and normal tissues while the expressions and phosphorylation of p38, ERK, JNK, as well as the expressions of α-SMA, Col1 and FN1 in HSF cells were evaluated by immunoblot techniques. CCK-8 and Transwell assays were used to assess the effect of BTXA on the viability and motility of HSF cells.
Results: BTXA suppressed MAPK pathway in hypertrophic scar fibroblasts (p < 0.01). It also suppressed excessive collagen deposits in hypertrophic scar through MAPK pathway (p < 0.01), and restrained HSF growth and motility via MAPK pathway (p < 0.01).
Conclusion: BTXA suppresses hypertrophic scarring via MAPK pathway and thus, can potentially be developed as a drug for the treatment of hypertrophic scarring.
Sindicato e neoliberalismo: movimento sindical e crise do sujeito
Authors: Da Hora Pereira Guilherme 
Published: January 2024

Trata-se de artigo orientado a enfrentar a problemática relativa à crise do movimento sindical sob a égide do neoliberalismo. Para tanto, propõe-se situar o movimento sindical em sua dimensão imanente ao capitalismo e à negociação do excedente social produzido na relação social da produção de mercadorias mediada pela troca de força de trabalho, mudandTrata-se de artigo orientado a enfrentar a problemática relativa à crise do movimento sindical sob a égide do neoliberalismo. Para tanto, valendo-se de referencial teórico e metodológico vinculado à dialética materialista alicerçada por Louis Althusser e, posteriormente, desenvolvida por Alysson Mascaro, Anselm Jappe, Robert Kurz e Moishe Postone, para, a partir da investigação das relações estabelecidas entre o movimento sindical e as formas sociais do capital sob a racionalidade neoliberal, situar o movimento sindical em sua dimensão imanente ao capitalismo e à negociação do excedente social produzido na relação social da produção de mercadorias mediada pela troca de força de trabalho, visando identificar o papel do movimento sindical no plano do assujeitamento da condição de trabalhador e, assim, oferecer uma resposta à percepção geral de que se atravessa, sob o neoliberalismo, uma crise sem precedentes do movimento sindical.o identificando o papel do movimento sindical no plano de assujeitamento da condição operatória.

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S.N. Maksudi and Russian Masons at the beginning of the XX century
Authors: Gaynanova М. R. 
Published: January 2024

The article investigates little-known facts in the life of the famous Tatar and Turkish public figure S.N. Maksudi – a turkologist, an educator, a deputy of the State Duma of the Russian Empire and the Majlis of the Turkish Republic at different periods of his life. At the beginning of the XX century a graduate of the Sorbonne University, a young lawyer, Sadri Maksudi, found himself at the center of the political life of the Turkic-Muslim world of Russia. He lived in St. Petersburg and was actively engaged in political activities. Just then he met Russian Freemasons and became a participant in the Masonic movement.The attitude towards Masonry in the Russian history is characterized by different assessments, for example, they were credited with participation in conspiracies, possession of secret knowledge, etc. In fact, most Masons were liberals who advocated the introduction of a wide range of democratic freedoms in Russia, including expanding the rights of national minorities. This attracted one of the leaders of Russian Islam, who actively defended the ideas of equality and enlightenment of his people.The article presents the analysis of the history of the opening of Masonic lodges in St. Petersburg after the revolution of 1905-1907 and their activities during the inter-revolutionary period, in which S.N. Maksudi took part.The purpose of the study was to analyze the views of the Tatar politician S.N. Maksudi through the prism of his participation in Masonic organizations of the early XX century. For this purpose the author used biographical, historical-genetic and historical-comparative research methods, as well as general scientific and dialectical methods of analysis. As a result, we came to the conclusion that despite all the objective differences between the social movement of Muslims in Russia and the teachings of the Freemasons, there were common ideological ideas between them, which attracted the Tatar-Muslim leader Sadri Maksudi to the ranks of the masons, which was reflected in his political life.
Social partnership in law enforcement: theoretical and methodological aspects of the research
Authors: Laschenov M. S. 
Published: January 2024

The relevance of the research topic is determined by the search for the reasons for the unsatisfactory practice of building social partnerships in the law enforcement sphere. The main problem of the current state of affairs, according to the author, is the presence of an axiological barrier in the minds of the intended subjects of interaction: internal affairs bodies and public law enforcement organizations. The length of time it takes to overcome the axiological barrier, as well as the lack of progressive dynamism in building an effective system, are burdened by a lack of understanding of the nature of the phenomenon of social partnership. This circumstance contributed to the dominance of a predominantly normative basis for mobilizing the movement of «social activists» and predetermined the administrative-command methods of stimulating public activity «from above.» This has given rise to simulation and over-centralized practices that exclude the value content of the communication process, initiative, interest, independence, personal responsibility and other mandatory attributes of a partner form of interaction.The purpose of the research is to determine the essential characteristics of social partnership, systematization and accounting of which will allow us to propose a conceptual basis for its formation in the law enforcement sphere. The research method is abstract situation modeling where the development of partnerships is analyzed through a system-activity approach. It makes possible to study both the systemic properties of social partnership and the specifics of the activity content of the analyzed model, which generates successful joint actions of subjects in the process of building a social partnership.The results and key conclusions of the research have made it possible to describe the essential features of the partnership form of interaction, present the author’s definition of social partnership in the law enforcement sphere and propose the main directions for its activation in order to build truly partnership practices.
Survival and Success of Dental Implants Placed in a University Setting
Authors: Choe Teebok , Miguez Patricia , Walter Ricardo , Musskopf Marta 
Published: January 2024

Purpose: The aim of this study was to assess the impact of experience and specialty training on the success and survival of dental implant therapy for single-unit fixed restoration of missing teeth in a university setting.
Methods: A retrospective study was conducted using data from the electronic patient record system at the Adams School of Dentistry. The Office of Computing and Information Systems provided dental records from January 1, 2013 to December 31, 2018, following the inclusion criteria. The records were manually reviewed by one evaluator (TC). Extracted from the records were subjects’ demographics; medical, dental, and social history; implant parameters; grafting procedures; and timing of placement/restoration/loading. Also recorded were the specialty training and level of experience, i.e., pre-doctoral student, resident, and faculty; the restoration type; radiographic confirmation of osseointegration before restoration; and occlusal splint fabrication. Fisher’s Exact Test was applied to determine if the providers’ specialty training and experience had any statistical significance on implant success and survival.
Results: A total of 501 implants were included in the study. Statistically significant were provider training (AEGD versus specialties, implant survival and success), subject’s gender (implant survival), implant type/manufacturer (implant survival and success), and immediate placement (implant survival). The overall survival rate was 97.0% while the success rate was 85.4%.
Conclusion: The type of clinical training impacted implant outcome, only when comparing AEGD versus specialties. Operator’s experience has no significance on the results.
Lifestyle vs Transplantation Therapies Aiding in Pancreatic Beta Cell Protection for Type 1 Diabetes
Authors: Stierli Micah , Abdalbari Ali , Pore Arya 
Published: January 2024

Pancreatic beta cells highly influence the level of insulin within the body. This being due to the beta cell’s ability to create and regulate the production of insulin (the hormone that manages blood sugar extent). Unfortunately, the increasing death rate of these cells has complicated insulin independence for people with type 1 and type 2 diabetes. Type 1 diabetes (T1D) continues to be a serious concern considering the globally growing incidence rate and the regard that there is no currently confirmed cure. However, multiple new cellular therapies have been explored and evaluated to aid in beta cell regeneration strategies. This literature review focuses specifically on commonly practiced beta cell regeneration therapies for type 1 diabetes. These therapeutic approaches were divided to fit into one of two categories, these categories being cellular reproduction and cell replacement which will be further expanded on throughout this article. Topics discussed within the work aim to exhibit a brief overview of the type 1 diabetes patient population, beta cell pathophysiology, and cover concepts regarding methods of measuring procedural success. The majority of this article will be centered around commonly practiced clinical strategies involving pancreas/islet cell transplantation and therapeutic lifestyle approaches. All this is concluded with a general comparison of typical beta cell therapies.
Diet for a Better World: Exploring the Intersectional Impact of Meat-based vs Plant-Based Diets and First Steps for Change
Authors: Mankarios Celina 
Published: January 2024

Humanity is faced with numerous pressing issues from the health crisis and human rights violations to climate change and animal cruelty. Although various methods are being employed to solve these issues, dietary changes are often overlooked. Unbeknownst to many people, the meat, dairy and fish industries continue to play a substantial role in perpetuating environmental degradation, animal cruelty, and human rights issues. However, the adoption of a 'plant-based' or 'vegan' diet emerges as a powerful catalyst for yielding widespread change in these issues. This research paper aims to explore the importance of transitioning society away from animal-based diets and towards plant based meals. Addressing a spectrum of urgent issues, this paper underscores the often underestimated potential of transitioning to plant-based diets as a potential solution to human, animal and environmental issues. The paper commences with a meta-analysis, employing an intersectional lens of human ethics, animal ethics, environmental concerns, and health perspectives, to evaluate the negative repercussions of animal agriculture industries. Perceived negatives of plant-based diets will then be explored to holistically conceptualize whether veganism is a valid and feasible option for individual and societal change. Lastly, drawing from prior studies and acknowledging the barriers of transitioning to a plant-based lifestyle, the paper culminates in proposing first steps for creating a successful plant-based transition: the implementation of plant-based meals and education in schools.
A Comprehensive Review on the Surgical Landscape in Breast Cancer Management
Authors: Alteneiji Alya Saeed Ali Khamis , Almheiri Ali Mohamed Alsari , Saleh Mohamed 
Published: January 2024

Purpose: The purpose of this narrative review is to examine the literature on the topic of breast surgery and its benefits for women with metastatic breast cancer. Breast surgery can involve either a mastectomy, which involves removing the entire breast along with lymph nodes, nipple, and areola, or a lumpectomy, which involves removing breast tissue and tumour but leaving the nipple and areola intact.
Methodology: We included any English-language study published between 2000 and 2021 that looked at the effects of breast surgery on survival or quality of life for women with metastatic breast cancer, whether it was an interventional study or an observational study. We utilised a combination of keywords like "Breast surgery," "mastectomy," "lumpectomy," "metastatic disease," "survival," "observational studies," "intervention studies," and "quality of life" to scour sources like PubMed and Embase. We considered randomised controlled trials that contrasted hormonal therapy, radiation, chemotherapy, biologic therapy, and supportive care with breast surgery alone or in combination with systemic therapy. A variety of outcomes were considered, including overall survival, quality of life, toxicity from local treatment as measured by one-month mortality, survival without progression, and survival specific to breast cancer.
Findings: The evidence from randomised controlled trials is limited and not conclusive, while observational studies do suggest that breast surgery may benefit with metastatic breast cancer. Since observational studies are prone to problems like selection bias and unmeasured confounding, it is difficult to draw any conclusions regarding the advantages of breast surgery without solid proof from RCTs.
Implications to Theory, Practice and Policy: Each woman diagnosed with metastatic breast cancer should be considered individually when deciding whether or not to undergo surgery. This should be done until results from big ongoing RCTs are available. When considering treatment options, the patient and doctor must weigh the pros and cons of each, as well as the associated costs. The current lack of strong evidence calls for more randomised controlled trials (RCTs) in both developing and developed nations, with bigger sample sizes.
Peningkatan Perkembangan Kognitif Siswa melalui Musik dan Lagu dalam Pembelajaran
Authors: Octavyanti Ni Putu Liana , Suarni Ni Ketut , Margunayasa I Gede 
Published: January 2024

Penelitian ini bertujuan untuk mendeskripsikan pengaruh peningkatan perkembangan kognitif siswa melalui musik dan lagu dalam pembelajaran. Pembelajaran di sekolah harus dilakukan dengan cara yang menyenangkan serta menciptakan kebermaknaan. Salah satu caranya dengan menggunakan musik dan memperkenalkan lagu anak-anak. Melalui musik dan lagu dalam pembelajaran, siswa akan mampu mengembangkan kognitifnya dan sesuai dengan realita kehidupan. Penelitian ini menggunakan metode studi literatur dengan 4 tahapan yakni memilih topik yang akan di review, memilih artikel yang relevan, melakukan analisis dan sintesis literatur, serta mengorganisasi penulisan review. Data dianalisis dari hasil temuan jurnal, artikel ilmiah, literatur review yang berisi tentang rancangan yang akan di teliti, lalu menyusun hasil temuan yang telah di review. Hasil dari penelitian ini menunjukkan bahwa pembelajaran menggunakan musik dan lagu memiliki pengaruh terhadap perkembangan kognitif siswa di sekolah dasar yang meliputi: memperkuat pemahaman konsep, meningkatkan hasil belajar siswa, mampu memecahkan suatu masalah, berpikir kritis, dan meningkatkan kreativitas siswa. Selain itu juga dapat menimbulkan rasa senang, gembira, dan semangat belajar hingga mampu menciptakan suasana pembelajaran yang menyenangkan.
Effects of Preferred versus Nonpreferred Music on Bench Press Performance
Authors: Hutchinson Jasmin C. , Murphy Jennifer , De Lucia Bianca , O'Neill Elizabeth , Curtis Diana , Mellano Kathleen T. , Pelton Luke , Coker Nicholas 
Published: January 2024

Replication is a fundamental aspect of scientific research, yet few replications have been conducted within strength and conditioning. In this paper we attempt to replicate and extend previous research on the effects of preferred (PREF) vs. nonpreferred (NON-PREF) music on bench press performance and motivation using a close replication of a study by Ballmann et al. (2021). The replication sample included 28 resistance-trained men (Mage = 20.5 years, SD = 1.5), while the extension sample (n = 47) comprised resistance-trained men and women (Mage = 20.6 years, SD = 1.5). Participants listened to PREF and NON-PREF music in a repeated-measures counterbalanced design, while completing bench press repetitions to failure (RTF). Concerning the replication attempt, we found no difference between music conditions for RTF (p = 0.545, Cohen’s dz = 0.12), and the replication and original effect sizes were incompatible (z = -1.88, p = 0.036). For motivation there was no difference between music conditions (p = 0.084, dz = 0.34) and the effect size estimate was incompatible with the original (z = -4.44, p < 0.001). Thus, the original study findings were not replicated. In the extension study, a two-way ANOVA showed no interaction or main effects of sex and music genre on RTF (p > 0.05). There were, however, main effects of sex (p = 0.015) and genre (p = 0.025) on motivation. In addition, attentional focus was different (more dissociative) for PREF vs. NON-PREF music (z = -3.11, p = 0.002), but perceived exertion did not differ between music conditions (p = 1.00, dz = 0.00). Results indicate that music preference does not have a robust effect on bench press performance and associated psychological factors. Athletes, exercisers, and practitioners are encouraged to utilize music that complements the task rather than considering genre preference.
ĐẶC ĐIỂM LÂM SÀNG VÀ DỊCH TỄ VIÊM GIÁC MẠC DO MICROSPORIDIA
Authors: Trần Khánh Sâm , Nguyễn Thị Vân Quỳnh 
Published: January 2024

Mục tiêu: Mô tả đặc điểm lâm sàng các mắt viêm, loét giác mạc (VLGM) do Microsporidia được ghép giác mạc xuyên điều trị tại Bệnh viện Mắt Trung ương và xác định yếu tố nguy cơ gây bệnh và yếu tố chỉ định ghép. Đối tượng và phương pháp: Nghiên cứu mô tả hồi cứu trên các mắt viêm, loét giác mạc do Microsporidia đã được ghép giác mạc xuyên điều trị tại Bệnh viện Mắt Trung ương từ tháng 1 năm 2018 đến tháng 12 năm 2020. Tiến hành thu thập thông tin về dịch tễ, yếu tố nguy cơ, đặc điểm lâm sàng, điều trị. Kết quả: Nghiên cứu thực hiện trên 63 mắt của 62 bệnh nhân, nữ giới chiếm ưu thế (74,6%), 1 bệnh nhân có tổn thương cả 2 mắt. Độ tuổi trung bình trong nghiên cứu là 60,8±10,1 tuổi. Thời gian diễn biến triệu chứng đến khi chẩn đoán xác định là 10,1 ± 9,7 tháng (từ 1,3 đến 50,2 tháng). Yếu tố nguy cơ gây bệnh phổ biến liên quan đến chấn thương mắt (15,9%), tra nhỏ steroid kéo dài (31,7%), bệnh lí bề mặt nhãn cầu (28,6%). Thị lực đa số mức thấp từ dưới ĐNT 3m là 92,0%. Yếu tố chỉ định ghép gồm có: viêm, loét giác mạc kém đáp ứng với điều trị (43 mắt,68,3%), loét doạ thủng và thủng (6 mắt, 9,6%). Kết luận: Yếu tố nguy cơ gây bệnh hàng đầu là chấn thương mắt liên quan đến nông nghiệp. Cần nghĩ đến Microsporidia khi bệnh diễn biến kéo dài, kém đáp ứng điều trị, dấu hiệu thực thể. Cần tăng cường tuyên truyền để nâng cao nhận thức của người dân.