bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients with type 1 diabetes and albuminuria have a reduced brain glycolytic capability that is correlated with brain atrophy
Authors: Vestergaard Mark B. , Laursen Jens Christian , Heinrich Niels Søndergaard , Rossing Peter , Hansen Tine Willum , Larsson Henrik B. W. 
Published: October 2023

IntroductionPatients with type 1 diabetes (T1D) demonstrate brain alterations, including white matter lesions and cerebral atrophy. In this case–control study, we investigated if a reason for this atrophy could be because of diabetes-related complications affecting cerebrovascular or cerebral glycolytic functions. Cerebral physiological dysfunction can lead to energy deficiencies and, consequently, neurodegeneration.MethodsWe examined 33 patients with T1D [18 females, mean age: 50.8 years (range: 26–72)] and 19 matched healthy controls [7 females, mean age: 45.0 years (range: 24–64)]. Eleven (33%) of the patients had albuminuria. Total brain volume, brain parenchymal fraction, gray matter volume and white matter volume were measured by anatomical MRI. Cerebral vascular and glycolytic functions were investigated by measuring global cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2) and cerebral lactate concentration in response to the inhalation of hypoxic air (12-14% fractional oxygen) using phase-contrast MRI and magnetic resonance spectroscopy (MRS) techniques. The inspiration of hypoxic air challenges both cerebrovascular and cerebral glycolytic physiology, and an impaired response will reveal a physiologic dysfunction.ResultsPatients with T1D and albuminuria had lower total brain volume, brain parenchymal fraction, and gray matter volume than healthy controls and patients without albuminuria. The inhalation of hypoxic air increased CBF and lactate in all groups. Patients with albuminuria had a significantly (p = 0.032) lower lactate response compared to healthy controls. The CBF response was lower in patients with albuminuria compared to healthy controls, however not significantly (p = 0.24) different. CMRO2was unaffected by the hypoxic challenge in all groups (p &gt; 0.16). A low lactate response was associated with brain atrophy, characterized by reduced total brain volume (p = 0.003) and reduced gray matter volume (p = 0.013).DiscussionWe observed a reduced response of the lactate concentration as an indication of impaired glycolytic activity, which correlated with brain atrophy. Inadequacies in upregulating cerebral glycolytic activity, perhaps from reduced glucose transporters in the brain or hypoxia-inducible factor 1 pathway dysfunction, could be a complication in diabetes contributing to the development of neurodegeneration and declining brain health.
Comparative assessment of fully laparoscopic Duhamel-Z with minimal rectorectal dissection vs. laparoscopy-assisted Duhamel-Z with blunt manual rectorectal dissection for total colonic aganglionosis
Authors: Miyano Go , Iida Hisae , Ebata Yu , Abe Eri , Kato Haruki , Mikami Takafumi , Ishii Junya , Lane Geoffrey J. , Yamataka Atsuyuki , Okazaki Tadaharu 
Published: October 2023

AimsEarly postoperative outcome (EPO) was compared between fully laparoscopic Duhamel-Z (F-Dz) and laparoscopy-assisted Duhamel-Z (A-Dz) anastomoses performed for total colonic aganglionosis (TCA).MethodsEPO was assessed quarterly for the first year after F-Dz/A-Dz using a continence evaluation score (CES) based on stool frequency (motions/day) and stool consistency (0 = liquid, 1 = soft, 2 = formed), presence of anal erosion (0 = severe, 1 = moderate, 2 = mild), and incidence of enterocolitis.Surgical technique involved taking the ileostomy down, dissecting the colon laparoscopically, and preparing the pull-through ileum through the stoma wound. In F-Dz (n = 3), a working port (SILS trocar) was inserted, and laparoscopic retrorectal dissection with forceps used to create a retrorectal tunnel from the peritoneal reflection extending downward as narrow as possible along the posterior wall of the rectum to prevent lateral nerve injury and preserve vascularity. After completing the tunnel, the ileum was pulled-through from an incision on the anorectal line and a Z-shaped ileorectal side-to-side anastomosis performed without a blind pouch. In A-Dz (n = 11), the retrorectal pull-through route was created through a Pfannenstiel incision using blunt manual (finger) dissection along the anterior surface of the sacrum.ResultsSubject backgrounds were similar. Mean quarterly data were: frequency (F-Dz: 4.67, 4.67, 4.67, 3.33) vs. (A-Dz: 7.27, 7.09, 6.18, 5.36) p &lt; .05; consistency (F-Dz: 0.33, 0.67, 0.67, 0.67) vs. (A-Dz: 0.27, 0.45, 0.70, 0.73) p = ns; anal erosion (F-Dz: 0.33, 0.33, 0.33, 0.67) vs. (A-Dz: 0.18, 0.36, 0.45, 0.64) p = ns; and enterocolitis (F-Dz: 1 episode in 1/3 cases or 33.3%) vs. (A-Dz: 7 episodes in 6/11 cases or 54.5%) p = ns.ConclusionsOverall, EPO after F-Dz was better than after A-Dz.
Female sex and burden of depressive symptoms predict insufficient response to telemedical treatment in adult attention-deficit/hyperactivity disorder: results from a naturalistic patient cohort during the COVID-19 pandemic
Authors: Praus Peter , Proctor Tanja , Rohrmann Tobias , Benedyk Anastasia , Tost Heike , Hennig Oliver , Meyer-Lindenberg Andreas , Wahl Anna-Sophia 
Published: October 2023

BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a chronic neuropsychiatric disorder, that typically manifests itself during childhood and persists in a majority of the affected individuals into adulthood, negatively affecting physical and mental health. Previous studies have shown detrimental effects of the COVID-19 pandemic on mental health in individuals with ADHD. Thus, telemedicine could be a useful tool for optimizing treatment-outcomes in adult ADHD by improving treatment adherence and persistence. However, data on telemedical treatment outcomes in adult patients with ADHD is scarce.MethodsWe report here the sub-cohort analysis of a naturalistic cohort of adult patients (N = 254) recruited between April 2020–April 2021, comparing the effects of telemedical treatment on participants either clinically diagnosed with depression (N = 54) or ADHD (N = 67). Participants were asked to fill out the WHO-5 repetitively during &gt;12 weeks of telemedical treatment. Furthermore scores of WHO-5, SCL-90R and BDI-II, psychopathology, psychosocial functioning, sociodemographic data, medical records and a feedback survey were analyzed for both groups and compared. Participants with ADHD were further stratified according to the development of well-being during the study period in order to identify factors associated with a satisfactory treatment outcome.ResultsParticipants with depression reported a significant improvement of well-being during the course of the study, while no such effect could be seen in participants with ADHD on a group level. Despite the good outcome, participants with depression were more severely affected at baseline, with significantly worse psychopathology and a more precarious labor and financial situation. A detailed analysis of ADHD participants without clinical improvement revealed significantly higher BDI-II scores than for ADHD participants with a satisfactory outcome (p = 0.03, Mann–Whitney-U-Test), suggesting successful treatment was hampered by the combination of ADHD and depressive symptoms. Furthermore, female sex among ADHD patients was correlated with an unfavorable treatment outcome during the course of the study (p = 0.001, Spearman correlation) as well as living with children (p = 0.02, Spearman correlation).ConclusionBesides screening for depressive symptoms before telemedical treatment, future research should address the specific needs of female ADHD patients as these patients may be at a particularly high risk of being overburdened with family work.
Empirical study on the factors influencing the successful aging of the middle-aged and older adult community volunteers
Authors: Chen Chien-Chih , Lan Yu-Li , Yan Yu-Hua 
Published: October 2023

BackgroundThe pursuit of successful aging is currently the most important research and policy issue in an aging society. Participating in voluntary services can help middle-aged and older adults recognize the positive value and benefits of social participation, feel a sense of happiness and accomplishment, and improve their overall life satisfaction, which can also contribute to successful aging. This study wants to understand whether the participation motivation and expectation confirmation of middle-aged and older adult volunteering will affect their continuous participation behavior and successful aging because of the satisfaction of actual participation?ObjectiveThis study explores the factors related to middle-aged and older adult volunteering participation and their impact on successful aging.MethodsMiddle-aged and older adult volunteering from the East Taiwan Community Development Association and community care centers were taken as the research objects. Convenience sampling was used to select volunteers who were over 45 years old (inclusive) and have participated in voluntary services over five (inclusive) times in the last 6 months. Respondents completed the questionnaire through self-completion or face-to-face interviews with the interviewer. The measurement tools include engagement motivation, expectation validation, satisfaction, ongoing engagement, and successful aging.ResultsA total of 536 questionnaires were distributed of which 498 were valid and 38 invalid. The questionnaire recovery rate was 92.91%. Statistical findings include: (1) Those who perceived that their health was good had a better successful aging status than those who perceived that their health was normal. (2) The volunteering participation motivation and expectation confirmation of middle-aged and older adults significantly affected their volunteer participation satisfaction. (3) Participation motivation and expectation confirmation predicted 50.8% of satisfaction. (4) Satisfaction predicted 47.1% of continuous participation. (5) Continuous participation and satisfaction had a predictive power of 65.1% for successful aging.ConclusionThis study confirms that the motivation and expectation of middle-aged and older adult to participate in volunteering will affect their continuous participation behavior and successful aging status through satisfaction. The research results can be used as a reference for the practical work plan of volunteering.
Complementary and alternative medicine use among people living with HIV in Shiraz, Southern Iran
Authors: Mosavat Seyed Hamdollah , Pasalar Mehdi , Joulaei Hassan , Ameli Vira , Heydari Seyed Taghi , Mirzazadeh Ali , Hashempur Mohammad Hashem 
Published: October 2023

BackgroundLiving with HIV requires lifelong care to support engagement with and adherence to antiretroviral therapy. The Middle East and North Africa region provides access to ART, but research is lacking on the lived-experiences of people living with HIV. Globally, complementary and alternative medicine (CAM) is increasingly used by patients who need support alongside receiving medical treatment for chronic conditions. This study aims to examine the frequency and reasons behind the use of CAM, as well as identify its associated factors among people living with HIV in Shiraz, Iran.MethodsIn this cross-sectional study, a total of 320 patients (aged 18–70 years) with a confirmed diagnosis of HIV residing in Fars province and diagnosed between 1999 and 2019 were recruited randomly through their clinical record numbers from five HIV treatment centers. They were surveyed on their quality of life and CAM use via the Short-Form Health Survey questionnaire (SF-36) and a semi-structured survey of “CAM use.” The data analysis for this study involved the use of Chi-squared test, independent t-test, and multiple logistic regression model.ResultsOf 287 patients, 89.22% reported using CAM in the previous year. CAM use was more prevalent among those with a family history of CAM use (94.3% vs. 81.8%, p = 0.023). Frequent reasons for using CAM were reported to be sexual dysfunction (32.4%), depression (28.3%), thirstiness (23.3%), and nausea (17.5%). Quality of life, as measured via the SF-36 questionnaire in all its 8 sub-domains, did not differ among those who used CAM versus those who did not (61.5 ± 27.6 vs. 58.1 ± 30.9, p = 0.626).ConclusionCAM was used among a majority of people living with HIV in Shiraz, Iran. People who used CAM appeared to experience a similar quality of life relative to those who did not use CAM. Future studies on the modalities of engagement with CAM can improve patient-physician shared decision-making and increase lifelong care options for people living with HIV.
Examining coordination and equilibrium: an analysis of supply index and spatial evolution characteristics for older adult services in Zhejiang Province
Authors: Ji Hao , Yu Yingying 
Published: October 2023

ObjectiveThis study aims to analyze the spatial distribution and dynamic evolution of older adult service supply in Zhejiang Province from 2010 to 2019. Additionally, this research seeks to propose an optimized resource allocation strategy for older adult care services, promoting regional fairness and coordinated development.MethodsTo evaluate the older adult service supply capacity, this research first constructed an evaluation index system based on the Chinese modernization development pattern. Then, an empirical analysis was carried out using a combination of the entropy-TOPSIS method, kernel density estimation, Markov chain analysis, Dagum Gini coefficient, and panel regression model.ResultsThe results show an overall upward trend in the supply and service capacity of older adult care in the whole province. However, the spatial distribution of older adult service supply capacity in Zhejiang Province still exhibits a gradient effect, even in the most recent year of 2019. Furthermore, the supply capacity of older adult services shifted to a higher level in the whole province, and regions with high supply capacity had a positive spillover effect on adjacent regions. The overall difference in the older adult service supply capacity of the province showed a decreasing trend. The level of economic development, urbanization rate, transportation capacity, the level of opening up, and the proportion of employees in the tertiary industry had a significant impact on the supply capacity and spatial difference of older adult services.ConclusionFrom the findings, this study puts forth countermeasures and suggestions to optimize the spatial distribution of older adult care services. This includes giving full play to the regional spatial linkage effect, promoting new-type urbanization construction, upgrading the transportation network, and expanding the opening up of the industrial structure. By implementing these measures, a more equitable and coordinated older adult services system can be developed in Zhejiang Province.
Sensory properties and consumer acceptance of plant-based meat, dairy, fish and eggs analogs: a systematic review
Authors: Appiani Marta , Cattaneo Camilla , Laureati Monica 
Published: October 2023

IntroductionOver the past years, several efforts have been made to formulate and develop plant-based substitutes of animal-based products in response to environmental changes, health issues and animal welfare. However, plant-based protein poses several challenges to product sensory characteristics, especially appearance, flavor, and texture. Despite this, current literature data have mainly reviewed nutritional, technological, and sustainability aspects of plant-based products with limited concerns on perceived sensory properties and perceptive barriers to consumption related to each specific substitute. To fill this literature gap, this systematic review aims to provide an up-to-date overview of the perceptive determinants of consumers' acceptance of plant-based substitutes of animal-origin products, including meat, dairy, fish and eggs analogs, with emphasis on product's intrinsic properties: appearance, smell, taste, and texture. Moreover, age-, gender-, and cultural-related differences in the appreciation/rejection of plant-based substitutes of animal-origin products were investigated.MethodsThe systematic analysis of the literature consulting Web of Science (Core Collection) and Scopus databases retrieved 13 research articles on meat, 26 on dairy, and two on fish and eggs analogs.Results and discussionResults showed that all sensory dimensions are influenced by the replacement of animal proteins with those of vegetable origin. However, the relative importance of appearance, odor, taste, and texture varied according to plant-based analogs category and mitigatory processing strategies to mask unpleasant sensory properties have been suggested for each category. Dairy analogs mainly suffer of aromas and flavors imparted by the raw materials, while both meat and dairy analogs have texture challenges. Meat analogs lack of juiciness, elasticity and firmness, while dairy analogs require uniform, creamy and thick texture. Moreover, very few studies analyzed the product's perception, considering age- and gender-related differences or cross-national/cultural differences. Future research should be addressed to specific product categories such as fish and eggs analogs as well as specific population targets including children and the elderly and consumers from developing countries.
PERANAN CITRA MEREK, KUALITAS PRODUK, DAN KEPUASAN KONSUMEN PADA LOYALITAS KONSUMEN SMARTPHONE MEREK APPLE
Authors: Tanzil Ferro Satria , Kristiawan Allen 
Published: October 2023

Perkembangan teknologi sudah sangatlah maju di era global saat ini. Terdapat banyak merek yang beredar dipasaran seperti Apple, Samsung, Oppo, dan sebagainya. Penggunaan Apple di Indonesia sendiri sangat banyak diminati oleh masyarakat karena dari segi merek, kualitas, hingga mencapai kepuasan sehingga mereka menjadi loyal kepada merek tersebut.Tujuan penelitian ini dibuat adalah untuk menguji dan menganalisis apakah ada peranan citra merek, kualitas produk, kepuasan konsumen pada loyalitas konsumen. Metode dalam penelitian yang dilakukan menggunakan teknik sampling yaitu purposive sampling dengan menyebarkan kuesioner ke 200 orang responden. Sampel dari penelitian yang dilakukan adalah orang yang menggunakan smartphone merek apple. Setelah mengumpulkan data maka akan diuji dengan uji validitas dan uji reliabilitas, serta uji asumsi klasik multikolonieritas dan heteroskedastisitas, uji regresi linear berganda. Dari hasil uji yang telah dilakukan menunjukkan ada dampak positif dari citra merek, kualitas produk, dan kepuasan konsumen pada loyalitas konsumen.
Tuning the flexural frequency of overhang-/T-shaped microcantilevers for high harmonics
Authors: Dat Le Tri , Cuong Nguyen Chi , Duy Vy Nguyen , Payam Amir F. 
Published: October 2023

Abstract
High-harmonic (HH) frequencies in microcantilevers impose several applications in precision detection thanks to the higher sensitivity of the higher modes in comparison to the fundamental modes. In this study, we showed that by tuning the cantilever length by changing the clamped position, the dimensional ratio of the overhang to the main cantilever part is altered and the HHs could be effectively obtained. Multiple HH frequencies have been achieved, from the 4th to 8th order of the second and from the 11th to 26th order of the third-mechanical mode versus the first mode, and these orders are much higher if higher modes are used. The analytical calculation is in agreement with available results of other groups. HH behavior when the cantilever interacts with the sample is also examined and is strongly dependent on the overhang parameters. These results could guide the experimentalist in the tuning and controlling of the HHs in detecting objects.
AI-Native Multi-Constraint Routing System and Method
Authors: Prihodko Maxim , Das Biswarup , Krantsevich Artem , Rakhimov Abdurasul , Vasilenko Eduard 
Published: October 2023

<p>The problem of multi-constraint routing is related to Multi-Objective Shortest Path Problem (MOSPP) and is known to be NP-hard. Despite decades of research, there is no state-of-the-art solution for this problem as Dijkstra algorithm for the single constraint case. This paper develops a systematic strategy to construct a model of an IP Network with multiple weight links and proposes a scalable and generalized AI-Native routing system and method (MORAI) to synthesize a composite cost to achieve optimal routing plane computation for multiple QoS-demands. The proposed method consists of an AI model and the training procedure and considers composite cost synthesis as an optimization process maximizing the number of feasible routes (satisfying multiple QoS-demands) in the Shortest Path Tree constructed with the composite cost as an edge weight. Using a composite cost for route identification with a Shortest Path First Algorithm guarantees that the routing is loop-free and fully distributed. The proposed system architecture is a combination of distributed and centralized modes. When the AI model is trained in a dedicated device, the following route computation is fully distributed, so the solution can be easily deployed in the current router architecture. Three system architectures are proposed, showing different combinations of AI-model training, execution, and composite cost computation in the network. Finally, the general paradigm of AI-Native Composite Cost synthesis is described, as well as the general AI model training scheme design is given. </p>
Navigation Antenna Pattern Retrieval after Measurement under Directed Irradiation from a Close Distance
Authors: Abuhadma Layth 
Published: October 2023

<p>Currently, interest in the prospects for practical implementation of methods that allow retrieving the true radiation pattern when irradiating the navigation antenna under test from an insufficiently large distance is noticeably growing. The use of directed radiation in this case, on the one hand, reduces the level of reflections from the walls of the chamber, but on the other hand, increases the heterogeneity of the irradiating field. The paper aims to elucidate the influence of the directed properties of the auxiliary antenna, which forms the irradiating field, on the measurement process and the accuracy of the radiation pattern retrieval, under the condition that both of them are by the methodology of a converging cluster of plane waves. Simulating measurement and data processing were carried out when the size of the auxiliary antenna varied. The simulation results confirm that the reconstruction accuracy is practically independent of the nature of the irradiating field. </p>