bluuebunny/crossref_metadata_2025_split huggingface dataset:
AD-Cloud: Health data visualization and monitoring equipment for Chinese Alzheimer’s patients based on the Wireless Body Area Network technology
Authors: Wu Yi , Zheng Minghong , Weng Changqing 
Published: January 2024

Abstract
Continuous visual health monitoring of Alzheimer's disease (AD) patients as a lifelong degenerative neurological disease has received increasing medical and design attention. Meanwhile, the Wireless Body Area Network (WBAN) technology, built on the Internet of Things (IoT), has been widely used in human health monitoring. However, it is unclear whether the visual analysis of multimodal data collected by WBAN is useful for the health monitoring of patients with AD. Therefore, this study aimed to demonstrate this issue and conducted a 12-month controlled trial. 16 AD patients worked with us and were divided into a traditional physical examination visualization group and a WBAN monitoring visualization group. In the WBAN monitoring visualization group, we innovated a digital kit called AD Cloud, which consists of a flexible wearable data collection and transmission device with a star topology, a high-calculus remote data visualization convolutional neural framework, and an interactive mobile application. It is worth highlighting the innovative visualization analysis, presentation and interaction methods for behavioral, physiological and psychological AD patients and WBAN technology, as well as the quantitative and qualitative analysis arguments combined with the "shopping out" example to check and analyze the differences in results. Finally, it is shown that in the field of health monitoring visualization, the innovative monitoring visualization device based on WBAN technology is more positive for AD patients than the traditional conventional medical examination. The results also show that continuous monitoring and visualization of highly identifiable information can lead to a more realistic picture of the health status of AD patients, improve collaboration between AD patients and their families, community caregivers, physicians and caregivers, provide effective support for social health decision making for AD patients, and ultimately respond quickly to the needs of AD patients.
Outcomes of Traumatic Cataract Surgery: A Retrospective Analysis of Visual Acuity and Refractive Error
Authors: Daryabari Seyed-Hashem , Jadidi Khosrow , Torabi Hamidreza , Hassani Mahmood , Kiarudi Mohammad Yaser , Saeedifar Mohammadreza 
Published: January 2024

Abstract

Purpose: To evaluate the visual and refractive outcome of cataract surgery and intraocular lens (IOL) implantation in adults with traumatic cataract.
Methods: Patients who underwent cataract surgery and IOL implantation due to closed or open eye injuries were included in this retrospective case series. All patients were contacted and asked for complete ocular reexamination. Medical records were also reviewed for baseline data, surgical details and complications.
Results: Seventy-two eyes from 72 patients (84.7% male) with mean age of 39.5±13.6 (range, 21-68) years were included. Forty-one (56.9%) eyes had open globe injuries and 31 (43.1%) eyes had closed globe injuries. Final corrected distance visual acuity (CDVA) was 20/40 or better in 43 (61.1%) eyes. The absolute prediction error was 1.0 diopter or less in 58.3% of eyes. There was no significant difference in final mean absolute prediction error between eyes with closed or open injuries (P>0.05). Eyes with open globe injury were more likely to achieve CDVA of 20/40 or less (Odds ratio, [95% confidence interval]: 0.331 [0.121-0.910]; P=0.032).
Conclusion: Visual acuity significantly improved after traumatic cataract extraction. Most cases achieved satisfactory visual acuity. Eyes with open globe injuries might have less favorable visual prognosis. Refractive outcome was similar in open and closed injuries.
Morphological and Molecular Characrerization of Wild Pomegranate (Punica Granatum l.)Genotypes to Estimate the Genetic Diversity Through Ssr Markers Collected From District Dir Khyber Pakhtunkhwa Pakistan
Authors: ULLAH JAMIL , AHMAD ISRAR , NISAR MOHAMMAD , MAHMOOD TARAQ , ullah irfan 
Published: January 2024

Abstract
The pomegranate (Punica graatum L.) is an local fruit of Pakistan, having a long history of cultivation as wild plant in warm temperate Himalayan range of the country; however its production is quite low to meet ever increasing market demand. Sustainable production of high quality pomegranate fruit in the world has been achieved through morphogenetic characterization and estimation of genotypes diversity. Thus, it is important to estimate morphological, and genetic diversity of wild pomegranate. In the present study 50 genotypes of wild pomegranate were collected from District Dir and estimated for eight morphological traits and randomly selected 18 genotypes out of 50 genotypes for molecular characterization by applying six SSR marker for estimation of genetic diversity. In this study eight morphological characters two qualitative and six quantitative trait were used for the determination of genetic diversity. Analysis of variance revealed that significant variations were found in fruit length and fruit width in PC4, PC5 and PC6. The principal component analysis of six quantitative variables revealed a total variation of (100%) with an Eigenvalue of 0.167%. PC1 has a total variation of 31.548%, PC2 has 19.054%, PC3 has 16.483%, PC4 has 15.85%, PC5 has 11.827% variation while PC6 has 5.237%. Cluster based analysis of six quantitative traits of wild pomegranate using ward method and all genotypes were divided into two linkage groups A at 33% genetic distance and B at 67% genetic distance. The genotypes P1 and P28 being the most diversified and is found at the extreme periphery of the Dendrogram. The highest genetic diversity was observed by primer pgSSR25 (0.85) and minimum gene diversity was recorded by primer PgSSR19 (0.500) a mean PIC value 0.70. Overall primers considerably diverse between all genotypes. The present result revealed superior genotypes, as P1, P2, P25 and P28 both morphogenaticaly which can be used as parents that certainly increase the chance of obtaining desirable genotypes in a breeding program. Moreover present results revealed that the both morphological characterization and molecular characterization provide a powerful tool for the estimation of genetic variations existing among the genotypes of Wild pomegranate This studies provide basic information for morphological and molecular diversity programs to develop new cultivars to enhance the production of high quality pomegranate with desirable traits in Pakistan.
Comprehensive Analysis of Glulam Delamination Though Finite Element Modelling Incorporating Physical and Mechanical Properties: A Case Study Using High Density Hardwood
Authors: Lu Peiqing , Gilbert Benoit P. , Kumar Chandan , McGavin Robert L. , Karampour Hassan 
Published: January 2024

Abstract
With the ongoing emphasis on sustainable and eco-friendly construction, there is a rising demand for high-strength and high-stiffness engineered wood products. This trend presents both opportunities and challenges for the Australia's hardwood industry, particularly concerning native forest-grown spotted gum (Corymbia citriodora). Glue laminated (glulam) spotted gum beams cannot be confidently commercialised due to the difficulty for its high-density to satisfy the bond integrity criteria (referred to as “delamination test”) for external products in accordance with the Australia and New Zealand Standard AS/NZS 1328.1 (1998). To investigate potential solutions for passing this delamination test, an accurate numerical model can be a valuable and time-efficient tool. The aim of this study is to develop and detail such a model, considering heat and mass transfer, drying stresses, plasticity and fracture propagation models, using COMSOL Multiphysics 5.5. The model was validated against a series of wetting and drying experiments on spotted gum glulam, considering both moisture content variation and crack propagation along the gluelines. Results from the validated model showed that delamination is principally due to the tensile stress applied to the gluelines. Through the comprehensive analysis of the moisture content and stress distributions during delamination test, alternative strategies for reducing delamination can be identified.
Carboxymethylated Rhizoma alismatis polysaccharides reduces the risk of calcium oxalate stone formation by reducing cellular inflammation and oxidative stress
Authors: Wang Zhi , Liu Li , Li Chuang-Ye , Zhao Yao-Wang , Tong Xin-Yi , Cheng Xiao-Yan , Ouyang Jian-Ming 
Published: January 2024

Abstract
Objective
This study aims to elucidate the mechanism and potential of Rhizoma alismatis polysaccharides (RAPs) in preventing oxidative damage to human renal proximal tubule epithelial cells.
Methods
The experimental approach involved incubating HK-2 cells with 100 nm calcium oxalate monohydrate for 24 h to establish a cellular injury model. Protection was provided by RAPs with varying carboxyl group contents: 3.57%, 7.79%, 10.84%, and 15.33%. The safeguarding effect of RAPs was evaluated by analyzing relevant cellular biochemical indicators.
Results
Findings demonstrate that RAPs exhibit notable antioxidative properties. They effectively diminish the release of reactive oxygen species, lactate dehydrogenase, and malondialdehyde, a lipid oxidation byproduct. Moreover, RAPs enhance superoxide dismutase activity and mitochondrial membrane potential while attenuating the permeability of the mitochondrial permeability transition pore. Additionally, RAPs significantly reduce levels of inflammatory factors, including NLRP3, TNF-α, IL-6, and NO. This reduction corresponds to the inhibition of overproduced pro-inflammatory mediator nitric oxide and the caspase 3 enzyme, leading to a reduction in cellular apoptosis. RAPs also display the ability to suppress the expression of the HK-2 cell surface adhesion molecule CD44.
Conclusions
The observed results collectively underscore the substantial anti-inflammatory and anti-apoptotic potential of all four RAPs. Moreover, their capacity to modulate the expression of cell surface adhesion molecules highlights their potential in inhibiting the formation of kidney stones. Notably, RAP3, boasting the highest carboxyl group content, emerges as the most potent agent in this regard.
Physical activity reduces the risk of anxiety associated with pesticide exposure
Authors: BAI LONG , Wen Zongliang , Wu Shenqin , Jin Yingliang , Chen Jialin , Jama Hamdi Abdirizak , Sawmadal Joyce D. 
Published: January 2024

Abstract

Objective
The purpose of this study was to examine whether there is an association between household pesticide exposure and anxiety symptoms in the United States and whether physical activity mitigates this association.
Methods
The study used data from the 2007–2012 National Health and Nutrition Examination Survey (NHANES), which included 13,728 American adult participants aged 20 years or older. Anxiety is defined as the presence of anxiety symptoms on 7 or more days in a 30-day. Information on recreational physical activity and pesticide exposure was self-reported in interviews. Logistic regression was used to assess the association between household pesticide use and anxiety symptoms.
Results
Participants exposed to household insecticides had a higher risk of anxiety symptoms compared to those not exposed (OR = 1.398, 95% CI: 1.239–1.576, p < 0.001). When grouped by physical activity, an association between different levels of physical activity and anxiety was found for the vigorous/moderate RPA group (OR = 1.350, 95% CI: 1.113–1.637, p = 0.002), and the light RPA group (OR = 1.434, 95% CI: 1.229–1.673, p < 0.001).
Conclusion
Household exposure to insecticides was positively associated with the development of anxiety disorders. The incidence of anxiety risk was relatively low in the vigorous/moderate RPA group after pesticide exposure compared to the light RPA.
Research on water level measurement technology based on the residual length ratio of image characters
Authors: Liu Mingtang , Wang Changchun , Huang Wei , Wang Xiaochen , Li Shihao , Lu Peng , Liu Xuemei , Jiang Enhui 
Published: January 2024

Abstract

Aiming at the low efficiency and poor adaptability of traditional water level measurement methods, a water level measurement technology based on the residual length ratio of image characters is proposed in this paper. First, by improving YOLOv5, the lightweight MobilenetV3 is used to replace CSPDarkNet53, and the CBAM attention mechanism is introduced to accurately locate the water gauge and the complete "E" character, and obtain the interface area between the residual "E" character and the water. Secondly, by improving U2-Net, the ordinary convolutions of RSU4-RSU7 in the decoding phase are replaced by depth-separable convolutions, and the ECA attention mechanism is introduced to improve the overall inference speed and accuracy to achieve the residual "E" character and the precise segmentation of water bodies. Finally, the water level value is calculated based on the residual length ratio of the characters. The experimental results show that the accuracy of the improved YOLOv5 is 98.12%, the average intersection over union ratio of the improved U2-Net is 86.23%, and the measurement error of water level is less than 1 cm, which meets the requirements of hydrological detection specifications. At the same time, the improved model reduces the number of parameters and computational complexity, which increases the speed of inference.
A survey on brachytherapy training of gynecological cancer focusing on the competence of residents in China.
Authors: Dong Mohan , Liu Changhao , Yan Junfang , Zhu Yong , Yin Yutian , Wang Jie , Wei Lichun 
Published: January 2024

Abstract

Background: the brachytherapy is an indispensable treatment for gynecological tumors, but the quality and efficiency of brachytherapy training for residents is still unclear.
Methods: An anonymous questionnaire was designed to collect information on gynecological brachytherapy (GBT) training for radiation oncology residents from 28 training bases in China. The questionnaire content was designed based on the principle of competency based medical education (CBME). The Likert scale was employed to evaluate self-reported competence and comprehension regarding GBT. A total of 132 senior residents were included in the final analysis.
Results: 53.79% (71/132) of senior residents had experience in performing image-guided GBT, whereas 76.52% (101/132) had observed the procedure during their standardized residency training. The proportion of senior residents who reported having the self-reported competence to independently complete the GBT was 78.03% for intracavity GBT, 75.00% for vaginal stump GBT, and 50.03% for interstitial GBT, respectively. The number of successful completion of Interstitial, intracavity and vaginal GBT was correlated with the self- confidence of trainees after standardized training. In particular, the independent completion of interstitial GBT for more than 20 cases was an independent factor for the self-reported competence of senior residents. During the training period, 50.76% and 56.82% of the residents had not participated in the specialized examinations and professional GBT courses.
Conclusion: The study revealed that the self-confidence of residents to independently complete brachytherapy was relatively high, and the specialized curriculum setting and training process assessment for brachytherapy training still need to be strengthened in the future.
Thiophene-based Solar Cell. A Review
Authors: D'Auria Maurizio , Emanuele Lucia 
Published: January 2024

Abstract:
In recent years, perovskite solar cells, which use a hybrid inorganic-organic material,
have also made remarkable progress and achieved a rapid increase in efficiency. The
organic materials used are usually small conductive molecules, polymers or oligomers. The
fused thiophenes, polythiophenes and olithiophenes used for this purpose are presented. The
condensed thiophene-based small molecule for DSSCs shows important properties such as
simplicity of synthesis and purification methods, well-defined and reproducible structures,
but low power conversion efficiencies. Polymers of thiophene for DSSCs show high power
conversion efficiencies, especially in ternary systems, even >19%; however, they have poor
long-term stability because of the molecular size and packing properties of the polymer
chains. Oligomers of thiophene for DSSCs have good long-term stability but low power
conversion efficiencies.
Role of Vitamin D in Gynecological Cancer: State of the Art
Authors: P Sruthi , Priya Mary , Varghese Treesa P. , Chand Sharad 
Published: January 2024

:
Vitamin D and Vitamin D Receptors have gained more importance beyond their roles in
bone metabolism and calcium homeostasis. Several epidemiological studies have confirmed that vitamin
D has a specific function in a wide variety of gynecological cancers, such as ovarian cancer,
endometrial cancer, cervical cancer, uterine fibroid, and vulvar cancer. The different anti-cancer
mechanisms exerted by vitamin D on tumor cells are cell proliferation, cancer progression, angiogenesis,
cell cycle arrest, and inflammation. The role of vitamin D is well emphasized in ovarian cancer
and uterine fibroids, with limited studies available on cervical cancer and other types of gynecological
cancers. Overall, most epidemiological data support that inadequate or low levels of vitamin D in
the circulation are associated with risk and poor prognosis in several types of gynecological cancer. It
is evident that vitamin D plays a prominent role as an anticancer agent against numerous types of
cancer. This review focuses on the etiology and role of vitamin D and the Vitamin D Receptor in various
types of gynecological cancer, as well as the mechanism of Vitamin D and its metabolites in the
management of gynecological cancer.
Integration of Artificial Intelligence, Machine Learning and Deep Learning Techniques in Genomics: Review on Computational Perspectives for NGS Analysis of DNA and RNA Seq Data
Authors: K. Chandrashekar , Niranjan Vidya , Vishal Adarsh , Setlur Anagha S. 
Published: January 2024

:
In the current state of genomics and biomedical research, the utilization of Artificial Intelligence
(AI), Machine Learning (ML) and Deep Learning (DL) have emerged as paradigm shifters.
While traditional NGS DNA and RNA sequencing analysis pipelines have been sound in decoding
genetic information, the sequencing data’s volume and complexity have surged. There is a demand
for more efficient and accurate methods of analysis. This has led to dependency on AI/ML and DL
approaches. This paper highlights these tool approaches to ease combat the limitations and generate
better results, with the help of pipeline automation and integration of these tools into the NGS DNA
and RNA-seq pipeline we can improve the quality of research as large data sets can be processed using
Deep Learning tools. Automation helps reduce labor-intensive tasks and helps researchers to focus
on other frontiers of research. In the traditional pipeline all tasks from quality check to the variant
identification in the case of SNP detection take a huge amount of computational time and manually
the researcher has to input codes to prevent manual human errors, but with the power of automation,
we can run the whole process in comparatively lesser time and smoother as the automated pipeline
can run for multiple files instead of the one single file observed in the traditional pipeline. In conclusion,
this review paper sheds light on the transformative impact of DL's integration into traditional
pipelines and its role in optimizing computational time. Additionally, it highlights the growing importance
of AI-driven solutions in advancing genomics research and enabling data-intensive biomedical
applications.
Potential of Nanomedicines as an Alternative for the Treatment of Colorectal Cancer
- A Review
Authors: Nicolau Costa Kammila Martins , Barros Larissa Alves , da Silva Soares Ingrid Larissa , Oshiro-Junior João Augusto 
Published: January 2024

Abstract::
Colorectal cancer is the third most common cancer and the second in cases of cancer-related death.
Polytherapy generates many adverse effects, leading the patient to give up. Nanotechnology has been studied in
recent years to circumvent limitations. Groups composed of polymeric, lipid, and inorganic nanoparticles are the
most purpose. Thus, the objective of this work is to bring information on how nanosystems can improve the
chemotherapeutic treatment for colorectal cancer. Therefore, a search in journals such as "LILACS", "SciELO"
and "PubMed/Medline" was performed, resulting in 25,000 articles found when applied the search engines "nanoparticle,"
"colorectal cancer," "malignant neoplasms," and "chemotherapy." After inclusion and exclusion
factors, 24 articles remained, which were used as the basis for this integrative review. The results reveal that,
regardless of the choice of matrix, nanoparticles showed an increase in bioavailability of the active, increasing the
half-life by up to 13 times, modified release, as well as a significant reduction in tumor size, with cell viability up
to 20% lower than the free drug tested, in different colorectal cancer cell lines, such as HCT-116, HT-29, and
CaCo-2. However, more in vivo and clinical studies need to be performed, regardless of the formulation of its
matrix, aiming at a higher rate of safety for patients and stability of the formulations, as well as knowledge of
detailed indices of its pharmacokinetics and pharmacodynamics, seeking to avoid further damage to the recipient
organism.