bluuebunny/crossref_metadata_2025_split huggingface dataset:
A previously healthy 3-year-old female with hypertension, proteinuria, and hypercalciuria
Authors: Liu Tao , Wang Wenhong , Liu Zhufeng , Pei Guanghua , Wang Chunxiang , Jiang Ying , Pang Chuyue 
Published: January 2024

AbstractA 3-year-old female patient with no significant medical history presented to her pediatrician with foamy urine. Initial testing revealed moderate proteinuria on qualitative testing, although she was incidentally noted to have severe hypertension (240/200 mmHg). Physical examination of the carotid and femoral areas revealed significant systolic vascular murmurs. Labs showed elevated serum creatinine, hypokalemia, metabolic alkalosis, elevated renin and aldosterone and hypercalciuria. Echocardiography identified ventricular hypertrophy. Computed tomography (CT) of the abdomen and magnetic resonance angiography of the head showed multiple tortuous or interrupted arteries and multiple calcifications in the renal sinus area. B-mode ultrasonography suggested thickening of the carotid and femoral artery walls, with numerous spotted calcifications. Genetic testing revealed that ABCC6 had a complex heterozygous mutation (exon 24: c.3340C > T and intron 30: c.4404-1G > A). Our panel of experts reviewed the evaluation of this patient with hypertension, proteinuria, hypercalciuria, and vascular abnormalities as well as the diagnosis and appropriate management of a rare disease.
Body dissatisfaction and dieting among Finnish adolescents: a 20-year population-based time-trend study
Authors: Mishina Kaisa , Kronström Kim , Heinonen Emmi , Sourander Andre 
Published: January 2024

AbstractBody image has an important role in the health and development of adolescents. Body dissatisfaction and dieting can become chronic and continue into adulthood. There is a lack of recent, comprehensive studies on ongoing trends on body dissatisfaction. This study assessed time-trend changes in self-reported body dissatisfaction and dieting among Finnish adolescents at four assessment points. Representative samples of adolescents (N = 6660) aged 13–16 years participated in school-based, cross-sectional studies in 1998 (N = 1458), 2008 (N = 2044), 2014 (N = 1809), and 2018 (N = 1349), respectively. The studies were similar in design, methodology, and geographical recruitment areas. Body dissatisfaction and dieting were assessed with a questionnaire including items derived from the DSM-IV criteria for anorexia and bulimia nervosa. From 1998 to 2018, dieting and fears related to gaining weight decreased among females. Body dissatisfaction reduced among females, and their wishes to become thinner became less prevalent. Consuming large amounts of food at one time consistently decreased among females and males and there were no changes in the rates of willful vomiting. The number of females in the 90th percentile with the most severe symptoms decreased. The results indicate that body dissatisfaction and disturbed dieting improved among females during the 20-year study. Despite these positive developments, the overall level of symptoms among females remained substantial, indicating that females have much higher levels of body dissatisfaction and dieting than males.
A hydrogeological overview of the Upper Mega Aquifer System on the Arabian Platform
Authors: Rausch Randolf , Dirks Heiko 
Published: January 2024

AbstractWith an extent of ~1,860,000 km2, the Upper Mega Aquifer System on the Arabian Platform forms one of the largest aquifer systems of the world. It is built up by several bedrock aquifers (sandstone and karstified limestone aquifers), which are imperfectly hydraulically connected to each other. The principal aquifers are the Wasia-Biyadh sandstone aquifer, and the karstified Umm Er Radhuma and Dammam limestone aquifers. The stored groundwater is mainly fossil. Groundwater recharge took place in the geologic past under more humid climatic conditions. Due to the good water quality and high yield, the aquifers are intensively exploited, which has caused depletion of the groundwater resources. The presented qualitative and semi-quantitative description of the hydrogeology and the groundwater budget is the basis for integrated groundwater management of the aquifer system.
A configurable mining approach for enhancing the business processes' performance
Authors: Bayomy Noha Ahmed , Khedr Ayman E. , Abd-Elmegid Laila A. 
Published: January 2024

AbstractBusiness is a war to get the attention you deserve from your enemies, and many competitors strive to gain a prominent position. Organizations are constantly seeking innovative ways to work to stay in a competitive business environment. Business process reengineering (BPR) is one of the most management approaches that are adopted by many organizations in order to achieve a dramatic increase in performance and cost reduction. Since the risks enfolded and failure rates related to BPR projects are very high, it is necessary to find ways to support success of BPR in a systematic approach. The major target of this article is to find the implementation of the proposed model to reengineer business processes (BPs) successfully via integrating critical success factors (CSFs) of BPR and BPs' performance. It is created to detect the inefficiencies and bottlenecks in the business process, decrease costs, time and increase quality of business processes, enhance financial environment and make an effective and efficient performance of the business process. It also applies a mining technique of association rule to examine the link between CSFs and several BPs and measures business processes' performance (intended BPR success) by process time, cycle time, quality and cost pre and post reengineering BPs. Thus, it uses a way to select the appropriate model for each business process. The proposed model will be implemented using a real world the Egyptian tax authority case study in order to prove its usefulness and efficiency. Then, inferred CSFs were applied according to each process, which proved the validity and success of the proposed model.
Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Authors: Engström Gunnar , Lampa Erik , Dekkers Koen , Lin Yi-Ting , Ahlm Kristin , Ahlström Håkan , Alfredsson Joakim , Bergström Göran , Blomberg Anders , Brandberg John , Caidahl Kenneth , Cederlund Kerstin , Duvernoy Olov , Engvall Jan E. , Eriksson Maria J. , Fall Tove , Gigante Bruna , Gummesson Anders , Hagström Emil , Hamrefors Viktor , Hedner Jan , Janzon Magnus , Jernberg Tomas , Johnson Linda , Lind Lars , Lindberg Eva , Mannila Maria , Nilsson Ulf , Persson Anders , Persson Hans Lennart , Persson Margaretha , Ramnemark Anna , Rosengren Annika , Schmidt Caroline , Skoglund Larsson Linn , Sköld C. Magnus , Swahn Eva , Söderberg Stefan , Torén Kjell , Waldenström Anders , Wollmer Per , Zaigham Suneela , Östgren Carl Johan , Sundström Johan 
Published: January 2024

AbstractReduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.
Engineers on responsibility: feminist approaches to who’s responsible for ethical AI
Authors: Drage Eleanor , McInerney Kerry , Browne Jude 
Published: January 2024

AbstractResponsibility has become a central concept in AI ethics; however, little research has been conducted into practitioners’ personal understandings of responsibility in the context of AI, including how responsibility should be defined and who is responsible when something goes wrong. In this article, we present findings from a 2020–2021 data set of interviews with AI practitioners and tech workers at a single multinational technology company and interpret them through the lens of feminist political thought. We reimagine responsibility in the context of AI development and deployment as the product of work cultures that enable tech workers to be responsive and answerable for their products over the long and short term. From our interviews, we identify three key pain points in understanding the distribution of responsibility between actors and developing responsible design and deployment practices: (1) unstable business ecosystems and AI lifecycles, which require an approach to responsibility that accounts for the dynamic nature of these systems; (2) the issue of incentivizing engineers to take responsibility for the mundane maintenance practices essential to the functioning of AI systems and (3) the need to overcome individual and structural barriers to taking ownership over AI products and their effects. From these findings, we make three recommendations based on feminist theory: (1) organisations should move from a static model of responsibility to a dynamic and ethically motivated response-ability; (2) companies need to revalue care and maintenance practices; and (3) firms must move away from individualistic ideas of responsibility towards fostering wider cultures of responsibility.
Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways
Authors: Li Minfang , Jia Dan , Li Jinshuai , Li Yaqing , Wang Yaqiong , Wang Yuting , Xie Wei , Chen Sheng 
Published: January 2024

AbstractAsthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Epithelial-mesenchymal transition (EMT) is an essential player in these alterations. Scutellarin is isolated from Erigeron breviscapus. Its vascular relaxative, myocardial protective, and anti-inflammatory effects have been well established. This study was designed to detect the biological roles of scutellarin in asthma and its related mechanisms. The asthma-like conditions were induced by ovalbumin challenges. The airway resistance and dynamic compliance were recorded as the results of AHR. Bronchoalveolar lavage fluid (BALF) was collected and processed for differential cell counting. Hematoxylin and eosin staining, periodic acid-Schiff staining, and Masson staining were conducted to examine histopathological changes. The levels of asthma-related cytokines were measured by enzyme-linked immunosorbent assay. For in vitro analysis, the 16HBE cells were stimulated with 10 ng/mL transforming growth beta-1 (TGF-β1). Cell migration was estimated by Transwell assays and wound healing assays. E-cadherin, N-cadherin, and α-smooth muscle actin (α-SMA) were analyzed by western blotting, real-time quantitative polymerase chain reaction, immunofluorescence staining, and immunohistochemistry staining. The underlying mechanisms of the mitogen-activated protein kinase (MAPK) and Smad pathways were investigated by western blotting. In an ovalbumin-induced asthmatic mouse model, scutellarin suppressed inflammation and inflammatory cell infiltration into the lungs and attenuated AHR and airway remodeling. Additionally, scutellarin inhibited airway EMT (upregulated E-cadherin level and downregulated N-cadherin and α-SMA) in ovalbumin-challenged asthmatic mice. For in vitro analysis, scutellarin prevented the TGF-β1-induced migration and EMT in 16HBE cells. Mechanistically, scutellarin inhibits the phosphorylation of Smad2, Smad3, ERK, JNK, and p38 in vitro and in vivo. In conclusion, scutellarin can inactivate the Smad/MAPK pathways to suppress the TGF-β1-stimulated epithelial fibrosis and EMT and relieve airway inflammation and remodeling in asthma. This study provides a potential therapeutic strategy for asthma.
Systematic analysis of the scientific-technological production on the use of the UV, H2O2, and/or Cl2 systems in the elimination of bacteria and associated antibiotic resistance genes
Authors: Espinosa-Barrera Paula Andrea , Gómez-Gómez Marcela , Vanegas Javier , Machuca-Martinez Fiderman , Torres-Palma Ricardo Antonio , Martínez-Pachón Diana , Moncayo-Lasso Alejandro 
Published: January 2024

AbstractThis study presents a systematic review of the scientific and technological production related to the use of systems based on UV, H2O2, and Cl2for the elimination of antibiotic-resistant bacteria (ARB) and genes associated with antibiotic resistance (ARGs). Using the Pro Know-C (Knowledge Development Process-Constructivist) methodology, a portfolio was created and analyzed that includes 19 articles and 18 patents published between 2011 and 2022. The results show a greater scientific-technological production in UV irradiation systems (8 articles and 5 patents) and the binary combination UV/H2O2(9 articles and 4 patents). It was emphasized that UV irradiation alone focuses mainly on the removal of ARB, while the addition of H2O2or Cl2, either individually or in binary combinations with UV, enhances the removal of ARB and ARG. The need for further research on the UV/H2O2/Cl2system is emphasized, as gaps in the scientific-technological production of this system (0 articles and 2 patents), especially in its electrochemically assisted implementation, have been identified. Despite the gaps identified, there are promising prospects for the use of combined electrochemically assisted UV/H2O2/Cl2disinfection systems. This is demonstrated by the effective removal of a wide range of contaminants, including ARB, fungi, and viruses, as well as microorganisms resistant to conventional disinfectants, while reducing the formation of toxic by-products.
Fresh air in the city: the impact of air pollution on the pricing of real estate
Authors: Miłuch Oktawia , Kopczewska Katarzyna 
Published: January 2024

AbstractThis study investigates the impact of ambient air pollution on housing prices in Warsaw, Poland, by examining spatial dependencies. The high concentration of particulate matter (PM10, PM2.5 and PM1) is expected to reduce real estate values. Using a hedonic model with approximately 15,000 observations and a spatial error model, we did not find evidence of this impact. Standard and premium housing submarkets differ in price determinants, but both are insensitive to environmental issues. This could be explained by the lack of comprehensive intra-urban historical information on air pollution, which limits investors’ rationality and their ability to properly value real estate based on environmental issues. Additionally, measurement and aggregation issues, along with low pollution variability within the city, may contribute to the insignificance of this information in real estate sales prices. Our empirical research confirms a strong link between air pollution and weather conditions within the city, where low temperatures and low-speed southern winds worsen contamination levels, while high temperatures and westerly winds improve air quality. Furthermore, we find that incorporating pollution data using PM yearly mean concentration works better in modelling than the PCA-reduced air pollution index.
Nanoparticle-enhanced coolants in machining: mechanism, application, and prospects
Authors: Hu Shuguo , Li Changhe , Zhou Zongming , Liu Bo , Zhang Yanbin , Yang Min , Li Benkai , Gao Teng , Liu Mingzheng , Cui Xin , Wang Xiaoming , Xu Wenhao , Dambatta Y. S. , Li Runze , Sharma Shubham 
Published: January 2024

AbstractNanoparticle-enhanced coolants (NPECs) are increasingly used in minimum quantity lubrication (MQL) machining as a green lubricant to replace conventional cutting fluids to meet the urgent need for carbon emissions and achieve sustainable manufacturing. However, the thermophysical properties of NPEC during processing remain unclear, making it difficult to provide precise guidance and selection principles for industrial applications. Therefore, this paper reviews the action mechanism, processing properties, and future development directions of NPEC. First, the laws of influence of nano-enhanced phases and base fluids on the processing performance are revealed, and the dispersion stabilization mechanism of NPEC in the preparation process is elaborated. Then, the unique molecular structure and physical properties of NPECs are combined to elucidate their unique mechanisms of heat transfer, penetration, and antifriction effects. Furthermore, the effect of NPECs is investigated on the basis of their excellent lubricating and cooling properties by comprehensively and quantitatively evaluating the material removal characteristics during machining in turning, milling, and grinding applications. Results showed that turning of Ti–6Al–4V with multi-walled carbon nanotube NPECs with a volume fraction of 0.2% resulted in a 34% reduction in tool wear, an average decrease in cutting force of 28%, and a 7% decrease in surface roughnessRa, compared with the conventional flood process. Finally, research gaps and future directions for further applications of NPECs in the industry are presented.
A spatial transformation-based CAN model for information integration within grid cell modules
Authors: Zhang Zhihui , Tang Fengzhen , Li Yiping , Feng Xisheng 
Published: January 2024

AbstractThe hippocampal-entorhinal circuit is considered to play an important role in the spatial cognition of animals. However, the mechanism of the information flow within the circuit and its contribution to the function of the grid-cell module are still topics of discussion. Prevailing theories suggest that grid cells are primarily influenced by self-motion inputs from the Medial Entorhinal Cortex, with place cells serving a secondary role by contributing to the visual calibration of grid cells. However, recent evidence suggests that both self-motion inputs and visual cues may collaboratively contribute to the formation of grid-like patterns. In this paper, we introduce a novel Continuous Attractor Network model based on a spatial transformation mechanism. This mechanism enables the integration of self-motion inputs and visual cues within grid-cell modules, synergistically driving the formation of grid-like patterns. From the perspective of individual neurons within the network, our model successfully replicates grid firing patterns. From the view of neural population activity within the network, the network can form and drive the activated bump, which describes the characteristic feature of grid-cell modules, namely, path integration. Through further exploration and experimentation, our model can exhibit significant performance in path integration. This study provides a new insight into understanding the mechanism of how the self-motion and visual inputs contribute to the neural activity within grid-cell modules. Furthermore, it provides theoretical support for achieving accurate path integration, which holds substantial implications for various applications requiring spatial navigation and mapping.
Imaging findings in inflammatory disease of the genital organs
Authors: Shibuki Saki , Saida Tsukasa , Hoshiai Sodai , Ishiguro Toshitaka , Sakai Masafumi , Amano Taishi , Abe Tetsuya , Yoshida Miki , Mori Kensaku , Nakajima Takahito 
Published: January 2024

AbstractThis review focuses on inflammatory diseases of female and male genital organs and discusses their epidemiology, pathogenesis, clinical presentation, and imaging findings. The female section covers pelvic inflammatory disease (PID) primarily caused by sexually transmitted infections (STIs) that affect the uterus, fallopian tubes, and ovaries. Unusual causes such as actinomycosis and tuberculosis have also been explored. The male section delves into infections affecting the vas deferens, epididymis, testes, prostate, and seminal vesicles. Uncommon causes such as tuberculosis, and Zinner syndrome have also been discussed. In addition, this review highlights other conditions that mimic male genital tract infections such as vasculitis, IgG4-related diseases, and sarcoidosis. Accurate diagnosis and appropriate management of these inflammatory diseases are essential for preventing serious complications and infertility. Imaging modalities such as ultrasound, magnetic resonance imaging, and computed tomography play a crucial role in diagnosis. Understanding the diverse etiologies and imaging findings is vital for the effective management of inflammatory diseases of the genital organs.
Human Rights in Hospitals: an End to Routine Shackling
Authors: Bedi Neil Singh , Mathur Nisha , Wang Judy D. , Rech Avital , Gaden Nancy , Annas George J. , Crosby Sondra S. 
Published: January 2024

AbstractMedical students (NSB, NM, JDW) spearheaded revision of the policy and clinical practice for shackling incarcerated patients at Boston Medical Center (BMC), the largest safety net hospital in New England. In American hospitals, routine shackling of incarcerated patients with metal restraints is widespread—except for perinatal patients—regardless of consciousness, mobility, illness severity, or age. The modified policy includes individualized assessments and allows incarcerated patients to be unshackled if they meet defined criteria. The students also formed the Stop Shackling Patients Coalition (SSP Coalition) of clinicians, public health practitioners, human rights advocates, and community members determined to humanize the inpatient treatment of incarcerated patients. Changes pioneered at BMC led the Mass General Brigham health system to follow suit. The Massachusetts Medical Society adopted a resolution authored by the SSP Coalition, which condemned universal shackling and advocated for use of the least restrictive alternative. This will be presented to the American Medical Association in June 2024. The Coalition led a similar effort to coauthor a policy statement on the issue, which was formally adopted by the American Public Health Association in November 2023. Most importantly, in an unprecedented human rights victory, a BMC patient who was incarcerated, sedated, and intubated was unshackled by correctional officers for the purpose of preserving human dignity.