bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimized decision algorithm for the microbiological diagnosis of osteoarticular infections in adults using synovial fluid samples: a prospective study in two French hospitals including 423 samples of synovial fluid
Authors: Dupieux Céline , Descours Ghislaine , Verhoeven Paul , Grattard Florence , Benito Yvonne , Vandenesch François , Cazorla Céline , Ferry Tristan , Lustig Sébastien , Boyer Bertrand , Boisset Sandrine , Carricajo Anne , Laurent Frédéric ,   PIRLA investigator group
Published: February 2024

Abstract. No consensus exists about the techniques to use for microbiological diagnosis of bone and joint infections (BJIs). The objective herein was to define an algorithm to optimize BJI diagnosis in adults using various bacteriological methods on synovial fluid samples. This prospective multi-center study included 423 synovial fluids collected from adult patients with suspected BJIs. Culture (using five solid media, an enrichment broth, and blood culture bottles), universal 16S rRNA PCR followed by Sanger sequencing, and seven specific bacterial PCRs were systematically performed. Combinations of methods were compared to arrive at the optimized algorithm. Among 423 synovial fluids, 242 infections were diagnosed (57.2 %): 213 mono- and 29 poly-microbial for a total of 284 bacteria (staphylococci at 54.6 %, streptococci–enterococci at 16.5 %, Gram-negative bacilli at 15.5 %, anaerobic species at 8.8 %). Comparing culture techniques, blood culture bottles had the highest sensitivity (67.6 % for pediatric and 63.9 % for anaerobic bottles) but are not sufficient alone and require being combined with solid media. The 16S rDNA PCR detected only 52.3 % of the bacteria, whereas specific PCRs had a higher sensitivity (Staphylococcus spp. at 66.2 %, S. aureus at 85.2 %, Streptococcus spp. at 91.2 %). Based on these results, an algorithm was proposed associating three solid media; inoculation into blood culture bottles; and 16S, Staphylococcus spp., and Streptococcus spp. PCRs, which would have detected 90.5 % of bacteria in the present cohort versus 79.2 % using all culture techniques on synovial fluid. This prospective study shows that a combination of culture and molecular methods on synovial fluids allows the optimization of bacterial detection.
Burden of routine orthopedic implant removal a single center retrospective study
Authors: AlOmran Ammar K , Alosaimi Nader , Alshaikhi Ahmed A , Bakhurji Omar M , Alzahrani Khalid J , Salloot Basil Ziyad , Alabduladhem Tamim Omar , AlMulhim Ahmed I , Alumran Arwa 
Published: February 2024

BACKGROUND
Open reduction and internal fixation represent prevalent orthopedic procedures, sparking ongoing discourse over whether to retain or remove asymptomatic implants. Achieving consensus on this matter is paramount for orthopedic surgeons. This study aims to quantify the impact of routine implant removal on patients and healthcare facilities. A retrospective analysis of implant removal cases from 2016 to 2022 at King Fahad Hospital of the University (KFHU) was conducted and subjected to statistical scrutiny. Among these cases, 44% necessitated hospitalization exceeding one day, while 56% required only a single day. Adults exhibited a 55% need for extended hospital stays, contrasting with 22.8% among the pediatric cohort. The complication rate was 6%, with all patients experiencing at least one complication. Notably, 34.1% required sick leave and 4.8% exceeded 14 d. General anesthesia was predominant (88%). Routine implant removal introduces unwarranted complications, particularly in adults, potentially prolonging hospitalization. This procedure strains hospital resources, tying up the operating room that could otherwise accommodate critical surgeries. Clearly defined institutional guidelines are imperative to regulate this practice.
AIM
To measure the burden of routine implant removal on the patients and hospital.
METHODS
This is a retrospective analysis study of 167 routine implant removal cases treated at KFHU, a tertiary hospital in Saudi Arabia. Data were collected in the orthopedic department at KFHU from February 2016 to August 2022, which includes routine asymptomatic implant removal cases across all age categories. Nonroutine indications such as infection, pain, implant failure, malunion, nonunion, restricted range of motion, and prominent hardware were excluded. Patients who had external fixators removed or joints replaced were also excluded.
RESULTS
Between February 2016 and August 2022, 360 implants were retrieved; however, only 167 of those who met the inclusion criteria were included in this study. The remaining implants were rejected due to exclusion criteria. Among the cases, 44% required more than one day in the hospital, whereas 56% required only one day. 55% of adults required more than one day of hospitalization, while 22.8% of pediatric patients required more than one day of inpatient care. The complication rate was 6%, with each patient experiencing at least one complication. Sick leave was required in 34.1% of cases, with 4.8% requiring more than 14 d. The most common type of anesthesia used in the surgeries was general anesthesia (88%), and the mean (SD) surgery duration was 77.1 (54.7) min.
CONCLUSION
Routine implant removal causes unnecessary complications, prolongs hospital stays, depletes resources and monopolizing operating rooms that could serve more critical procedures.
Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty
Authors: Okoro Tosan , Wan Michael , Mukabeta Takura Darlington , Malev Ella , Gross Marketa , Williams Claudia , Manjra Muhammad , Kuiper Jan Herman , Murnaghan John 
Published: February 2024

BACKGROUND
Prophylactic antibiotics have significantly led to a reduction in the risk of post-operative surgical site infections (SSI) in orthopaedic surgery. The aim of using antibiotics for this purpose is to achieve serum and tissue drug levels that exceed, for the duration of the operation, the minimum inhibitory concentration of the likely organisms that are encountered. Prophylactic antibiotics reduce the rate of SSIs in lower limb arthroplasty from between 4% and 8% to between 1% and 3%. Controversy, however, still surrounds the optimal frequency and dosing of antibiotic administration.
AIM
To evaluate the impact of introduction of a weight-adjusted antibiotic prophylaxis regime, combined with a reduction in the duration of administration of post-operative antibiotics on SSI incidence during the 2 years following primary elective total hip and knee arthroplasty
METHODS
Following ethical approval, patients undergoing primary total hip arthroplasty (THA)/total knee arthroplasty (TKA) with the old regime (OR) of a preoperative dose [cefazolin 2 g intravenously (IV)], and two subsequent doses (2 h and 8 h), were compared to those after a change to a new regime (NR) of a weight-adjusted preoperative dose (cefazolin 2 g IV for patients < 120 kg; cefazolin 3g IV for patients > 120 kg) and a post-operative dose at 2 h. The primary outcome in both groups was SSI rates during the 2 years post-operatively.
RESULTS
A total of n = 1273 operations (THA n = 534, TKA n = 739) were performed in n = 1264 patients. There was no statistically significant difference in the rate of deep (OR 0.74% (5/675) vs NR 0.50% (3/598); fishers exact test P = 0.72), nor superficial SSIs (OR 2.07% (14/675) vs NR 1.50% (9/598); chi-squared test P = 0.44) at 2 years post-operatively. With propensity score weighting and an interrupted time series analysis, there was also no difference in SSI rates between both groups [RR 0.88 (95%CI 0.61 to 1.30) P = 0.46].
CONCLUSION
A weight-adjusted regime, with a reduction in number of post-operative doses had no adverse impact on SSI incidence in this population.
PEMERIKSAAN KECACINGAN (SOIL TRANSMITTED HELMINTHS) DENGAN PENGARUH PHBS PADA ANAK DI DESA KARADENAN KABUPATEN BOGOR
Authors: Kurniawan Muhammad Rizki , Nirwana Rima , Yansen Aturut 
Published: February 2024

Kecacingan merupakan infeksi parasit berupa masuknya cacing ke dalam tubuh manusia. Salah satu faktor yang menyebabkan kecacingan adalah personal hygiene. Penularan kecacingan dapat terjadi apabila seseorang mempunyai personal hygiene yang buruk. Salah satu tempat yang memiliki risiko kecacingan adalah Desa yang kumuh. Penelitian ini bertujuan untuk menganalisis hubungan pemeriksaan kecacingan (Soil Transmitted Helminths) dengan pengaruh PHBS Pada Anak di Desa Karadenan Kabupaten Bogor. Jenis penelitian ini adalah Analitik dengan desain penelitian cross sectional. Sampel dalam penelitian ini adalah 99 orang yang memenuhi kriteria inklusi dan eksklusi dengan teknik pengambilan sampel purposive sampling. Pengumpulan data dilakukan dengan pengisian kuesioner dan pemeriksaan kecacingan (soil transmitted helminths) dengan metode natif. Pengolahan data menggunakan software statistika dengan uji Chi square. Hasil penelitian didapatkan ada hubungan antara pemeriksaan kecacingan dengan pengaruh PHBS Pada Anak di Desa Karadenan Kabupaten Bogor. Meskipun pada kenyataannya personal hygiene tidak menjadi penentu seseorang terkena kecacingan atau tidak, karena kecacingan juga dapat disebabkan oleh kondisi lingkungan, kelembapan suhu dan kepadatan penghuni.
Institutional-territorial arrangements and urban regimes: the residential verticalization process in Imperatriz (MA)
Authors: Da Silveira Keilha Correia , Pimentel Neto José Geraldo , Da Silva Tiago dos Santos , Andrade Tiago da Silva 
Published: February 2024

The project characterizes the institutional arrangements and urban regimes, verifying these factors in the urban space of Imperatriz (MA), by the role played in the framework of governance, facing the spatial dynamics in the institutional, political, economic and social articulations. Thus, it makes approaches focused on the urban growth of the process of verticalization of housing in the context of the residential real estate market of the second largest city of the state of Maranhão. Covering the study of public-private relations in the construction of urban space in the occasion of the coalitions in the middle city, thus seeking to understand the major urban projects, analyzing the forms of power and influence that present a certain role exercised in the urban-regional development. Therefore, using the case study methodology, this research aims to understand the Institutional Arrangements and Urban Regimes from the perspective of the governance of the city of Imperatriz (MA), focusing the process of verticalization of housing from the real estate market, verifying the dynamics of institutional coalitions from urban planning and management. The research has its importance in the development of research with an emphasis on urban geography, in the perspective of the understanding of institutional arrangements, urban regimes and institutional coalitions configurations in the local-regional scenario, which configure and produce the urban space of the city of Imperatriz (MA). Therefore, this research will demonstrate strategic decision situations in the urban dynamics of housing, services and the logic of the housing real estate market, verifying the process of verticalization in the city of Imperatriz (MA).
Scoliosis Without Fusion and Increased Risk of Early Medical and Surgery-Related Complications After Total Hip Arthroplasty: A Propensity-score Analysis
Authors: Sequeira Sean B. , Hasenauer Mark D. , McKinstry Robert , Ebert Frank , Boucher Henry R. 
Published: February 2024

Introduction:
There is a paucity of literature that examines how the abnormal spinopelvic alignment of scoliosis affects outcomes after total hip arthroplasty (THA) in the absence of a lumbar fusion.

Methods:
Patients with a history of scoliosis (idiopathic, adolescent, degenerative, or juvenile) without fusion and those without a history of scoliosis who underwent primary THA were identified using a large national database. Ninety-day incidence of various medical complications, emergency department (ED) visit, and readmission and 1-year incidence of surgery-related complications and cost of care were evaluated in both the scoliosis and control cohorts. Propensity score matching was used to control for patient demographic factors and comorbidities as covariates.

Results:
After propensity matching, 21,992 and 219,920 patients were identified in the scoliosis and control cohorts, respectively. Patients with scoliosis were at increased risk of several 90-day medical complications, including pulmonary embolism (odds ratio [OR] 1.96; P < 0.001), deep vein thrombosis (1.49; P < 0.001), transfusion (OR, 1.13; P < 0.001), pneumonia (OR, 1.37; P < 0.001), myocardial infarction (OR, 1.38; P = 0.008), sepsis (OR, 1.59; P < 0.001), acute anemia (OR, 1.21; P < 0.001), and urinary tract infection (OR, 1.1; P = 0.001). Patients with a history of scoliosis were at increased 1-year risk of revision (OR, 1.31; P < 0.001), periprosthetic joint infection (OR, 1.16; P = 0.0089), dislocation (OR, 1.581; P < 0.001), and aseptic loosening (OR, 1.39; P < 0.001) after THA. Patients with scoliosis without a history of fusion were more likely to return to the emergency department (OR, 1.26; P < 0.001) and be readmitted (OR, 1.78; P < 0.001) within 90 days of THA.

Discussion:
Patients with even a remote history of scoliosis without fusion are at increased risk of 90-day medical and surgery-related complications after hip arthroplasty. Hip and spine surgeons should collaborate in future studies to best understand how to optimize these patients for their adult reconstructive procedures.
PENGARUH BRAND IMAGE TERHADAP KEPUTUSAN PEMBELIAN MOBIL MEREK AVANZA PADA PT TOYOTA SUMBER HARAPAN DI TANJUNG REDEB
Authors: Edwar Ready  
Published: February 2024

The purpose of this study was to find out how much influence brand image has on purchasing decisions for a Toyota Avanza car at PT Toyota Sumber Harapan in Tanjung Redeb.
The method used in this study is a simple regression method to see the effect of brand image on purchasing decisions for the Toyota Avanza brand car and using the correlation coefficient to see how much influence the brand image has on purchasing decisions for the Toyota Avanza brand car at PT Toyota Sumber Harapan in Tanjung redeb.
Based on the results of the analysis, it is known that the influence of brand image on purchasing decisions for
the Toyota Avanza car is classified as strong, judging from the value of r = 0.995. In addition, based on the calculation of the correlation coefficient, it shows the value of r square = 0.989 indicating that 98.9% of the
decision to purchase a Toyota Avanza car is influenced by brand image, while the remaining 1.10% is influenced by other factors not examined.
Analisis CR,DER,ROE DAN DPR TERHADAP RETURN SAHAM PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEIPERIODE 2017 - 2021
Authors: Nasution Yuslinda , Septian Rizki Andri 
Published: February 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh CR, DER, ROE, dan DPR terhadap Return Saham pada bisnis. Sampel terdiri dari 17 bisnis Sub sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia periode 2017-2021, dipilih melalui metode purposive sampling. Analisis data melibatkan pendekatan deskriptif dan regresi linier berganda. Menggunakan data bersifat sekunder. hasil pengujian secara parsial menyatakan bahwa variabel Current Ratio (CR),Debt to Equity Ratio (DER), Return on Equity (ROE) secara parsial berpengaruh terhadap Return Saham, dan Kebijakan Deviden (DPR) tidak berpengaruh terhadap Return Saham. Dan hasil pengujian secara keseluruhan membuktikan bahwa variabel Current Ratio (CR), Debt to Equity Ratio (DER), Return on Equity (ROE), dan Kebijakan Deviden (DPR) keempatnya berpengaruh terhadap Return Saham
Impaired implicit emotion regulation in patients with panic disorder: An event-related potential study on affect labeling
Authors: Wang Hai-Yang , Li Li-Zhu , Chang Yi , Pang Xiao-Mei , Zhang Bing-Wei 
Published: February 2024

BACKGROUND
Panic disorder (PD) involves emotion dysregulation, but its underlying mechanisms remain poorly understood. Previous research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom maintenance. However, there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological indicators.
AIM
To study the neural mechanisms of implicit emotion regulation in PD with event-related potentials (ERP).
METHODS
A total of 25 PD patients and 20 healthy controls (HC) underwent clinical eva-luations. The study utilized a case-control design with random sampling, selecting participants for the case group from March to December 2018. Participants performed an affect labeling task, using affect labeling as the experimental condition and gender labeling as the control condition. ERP and behavioral data were recorded to compare the late positive potential (LPP) within and between the groups.
RESULTS
Both PD and HC groups showed longer reaction times and decreased accuracy under the affect labeling. In the HC group, late LPP amplitudes exhibited a dynamic pattern of initial increase followed by decrease. Importantly, a significant group × condition interaction effect was observed. Simple effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC group. Furthermore, among PD patients under the affect labeling, the late LPP was negatively correlated with disease severity, symptom frequency, and intensity.
CONCLUSION
PD patients demonstrate abnormalities in implicit emotion regulation, hampering their ability to mobilize cognitive resources for downregulating negative emotions. The late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.
Risk factors for cognitive impairment in patients with chronic kidney disease
Authors: Wang Xiao-Hui , He Yong , Zhou Huan , Xiao Ting , Du Ran , Zhang Xin 
Published: February 2024

BACKGROUND
Chronic kidney disease (CKD) patients have been found to be at risk of concurrent cognitive dysfunction in previous studies, which has now become an important public health issue of widespread concern.
AIM
To investigate the risk factors for concurrent cognitive dysfunction in patients with CKD.
METHODS
This is a prospective cohort study conducted among patients with CKD between October 2021 and March 2023. A questionnaire was formulated by literature review and expert consultation and included questions about age, sex, education level, per capita monthly household income, marital status, living condition, payment method, and hypertension.
RESULTS
Logistic regression analysis showed that patients aged 60-79 years [odds ratio (OR) = 1.561, P = 0.015] and ≥ 80 years (OR = 1.760, P = 0.013), participants with middle to high school education (OR = 0.820, P = 0.027), divorced or widowed individuals (OR = 1.37, P = 0.032), self-funded patients (OR = 2.368, P = 0.008), and patients with hypertension (OR = 2.011, P = 0.041) had a higher risk of cognitive impairment. The risk of cognitive impairment was lower for those with a college degree (OR = 0.435, P = 0.034) and married individuals.
CONCLUSION
The risk factors affecting cognitive dysfunction are age, 60-79 years and ≥ 80 years; education, primary school education or less; marital status, divorced or widowed; payment method, self-funded; hypertension; and CKD.
Rancang Bangun Alat Penggantian Baterai Untuk Forklift Plant 1B PT. Inti Ganda Perdana Karawang
Authors: Chorda Martinus , Toha Mochammad 
Published: February 2024

PT. Inti Ganda Perdana Karawang merupakan perusahaan yang memproduksi Axle Shaft, Rear Axle dan Front Axle. PT. IGP Karawang terdiri dari 2 plant, yaitu Plant 1A dan 1B. Untuk mendukung proses produksi di plant 1B, digunakan forklift yang berfungsi untuk mengangkut pallet dari satu line ke line yang lainnya. Forklift tersebut disewa dari Vendor. Forklift yang digunakan adalah jenis 1.5 ton dengan tenaga baterai. Jumlah forklift yang digunakan ada 2 unit, dimana salah satu forklift beroperasi, sementara forklift yang satunya berada di charging station untuk melakukan proses pengecasan dan dilakukan secara bergantian. Berdasarkan hasil analisa yang dilakukan penulis menentukan perlunya pengubahan sistem penggunaan forklift dari sebelumnya menggunakan 2 unit forklift, menjadi menggunakan 1 unit forklift dan 2 baterai untuk digunakan secara bergantian. Dengan pembuatan alat bantu penggantian baterai forklift, maka dapat membantu melepaskan dan memasukkan baterai forklift yang berat sehingga memudahkan operator dalam proses penggantian baterai forklift. Serta dapat mengurangi biaya sewa forklift menjadi 1 unit.
Moeilijke juristentaal (I)
Authors: Klik P. , Evertsz M. 
Published: February 2024

Moeilijke juristentaal (I)
Het onderwerp ‘moeilijke juristentaal’ wordt in de context van de discussie in Nederland over ‘klare taal’ geplaatst. Die discussie is niet zo ‘nieuw’ als op het eerste gezicht lijkt. In de tekst zijn veel citaten uit eerdere Amerikaanse literatuur verwerkt en wordt uiteengezet wat onder bestaande termen als ‘legalese’ en ‘gobbledygook’ wordt verstaan. Aan de hand van concrete voorbeelden (tips en lijsten met woorden) wordt nagegaan hoe en waar meer begrijpelijke taal kan worden gebruikt, waarbij met name aandacht wordt besteed aan het gebruik van ‘moeilijke woorden’. Tot slot worden opmerkingen gemaakt over ‘taal’ en ‘moeilijke woorden’ in de context van het Caribisch deel van het Koninkrijk.
El audiovisual en la difusión del español como lengua de integración en el contexto latinoamericano
Authors: De Souza Fábio Marques , Da Silva Ana Caroline Pereira , Bongestab Cristina , Maciel Helaine de Souza , De Macedo Junior Helenildo Arruda , Pereira Laís de Sousa Nóbrega Aguiar 
Published: February 2024

Este texto plantea fomentar la enseñanza del español lengua extranjera (E/LE) en contextos verosímiles de comunicación con un enfoque intercultural con vistas a la formación mediadores culturales. Para eso, presentaremos la orientación teórica que sostiene nuestras reflexiones y acciones, bien como principales metas en lo que concierne a la enseñanza, investigación y extensión. Esta propuesta se justifica por la importancia de pensarse en lo lingüístico cultural como elemento clave en el contexto de la integración latinoamericana. Nuestro objetivo es preparar al estudiante para que sea un mediador intercultural sensible a los discursos transmitidos mediante el lenguaje, por intermedio del texto fílmico. En este intento, sabemos que cabe al interculturalismo superar el etnocentrismo y el relativismo cultural y avanzar hacia la conquista de una actitud de respeto e igualdad que nos permita analizar otras culturas desde sus propios patrones de forma a permitir la intercomunicación entre ellas. En ese sentido, a partir de un relato de experiencia en la Universidade Estadual da Paraíba (UEPB), subrayamos las potencialidades del séptimo arte en colaborar con nuestro intento y como posibilidad para presentar al estudiante brasileño el español hablado en situaciones verosímiles de comunicación en los más variados rincones y, de esa manera, facilitar la adquisición de la lengua con miras a promover la intercomunicación cultural. Invertimos, por un lado, en una posición de respeto a las diferencias y, por otro, en la manifestación de la alteridad. El audiovisual, además de enriquecer las clases, son una opción fantástica como extensión del ambiente formal de aprendizaje y puede contribuir para el desarrollo de la autonomía en la búsqueda de conocimientos. Por lo tanto, el cine surge como un inmejorable aliado ya que las películas son producidas de forma contextualizada en la lengua meta, sin manipulaciones con fines didácticos.