bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ice age land bridges to continental islands: Repeated migration of the forest‐dwelling sable in northeastern Asia
Authors: Kinoshita Gohta , Sato Takuma , Murakami Shota , Monakhov Vladimir , Kryukov Alexey P. , Frisman Lyubov V. , Tsunamoto Yoshihiro , Suyama Yoshihisa , Murakami Takahiro , Suzuki Hitoshi , Sato Jun J. 
Published: January 2024

AbstractAimThe continental island system comprising Sakhalin, Hokkaido and the southern Kuril Islands (SHSK) in northeastern Asia serves as one of the southernmost habitats for many boreal and arctic organisms, with colonization via land bridges formed during glacial periods. To understand the impacts of past land‐bridge formation under Quaternary climate changes across SHSK, we investigated the demographic history of forest‐dwelling marten species.LocationSakhalin, Hokkaido and the southern Kuril Islands in northeastern Asia.TaxonSable, Martes zibellina (Carnivora, Mustelidae).MethodsWe employed multiplexed inter‐simple sequence repeat genotyping by sequencing (MIG‐seq) to obtain genome‐wide single nucleotide polymorphisms (SNPs). We tested possible scenarios of colonization and diversification for SHSK sables using several population genetics approaches including clustering analysis, population tree estimation and approximate Bayesian computation modelling. We also examined haplotype diversity for the mitochondrial ND2 gene.ResultsThe genetic diversity of the island populations and their affinity for continental populations were found to be higher in the order Sakhalin > Hokkaido > Iturup in both nuclear SNP and mitochondrial DNA analyses. Demographic analyses indicated that the sable migrated repeatedly from the continent, particularly to the neighbouring Sakhalin Island. However, only an earlier colonized lineage has persisted on marginal Iturup Island since the Middle Pleistocene. The stronger effects of repeated migrations and/or isolation influenced by the distance to the continent have shaped the contemporary genetic diversity and differentiation of sable populations in SHSK.Main ConclusionsGenome‐wide and comprehensive sampling approaches demonstrated that the forest‐dwelling sable had long‐term persistence with partial admixture of multiple lineages in SHSK, suggesting the existence of forest corridors and refugia on the islands during the last several glacial periods. The SHSK system of continental islands is valuable for understanding the impacts of Quaternary climate changes on the genetic diversity and evolutionary histories of boreal organisms.
Institutional and family support impact on health‐related quality of life of children with autism spectrum disorders during the COVID‐19 pandemic
Authors: Windarwati Heni D. , Lestari Retno , Hidayah Ridhoyanti , Hasan Haliza , Ati Niken A. L. , Kusumawati Mira W. , Selena Irhamna N. , Dumar Bergita , Rahayu Gemi 
Published: January 2024

AbstractProblemsChildren with autism spectrum disorder (ASD) tend to have a notably poorer quality of life than the general population, especially during the COVID‐19 pandemic. This study aimed to analyze the association between institutional support and family support on the health‐related quality of life (HRQoL) of children with ASD during the COVID‐19 pandemic.MethodsA cross‐sectional study was conducted in October 2022 in a School for Special Needs in Malang City, East Java Province, Indonesia. The pediatric quality of life inventory (PedsQL) and Institutional and Family Support questionnaire were used to measure the HRQoL and support perceived by parents of children with ASD. We analyzed each component of the PedsQL and the Institutional and Family Support questionnaire. The independent T‐test was performed to analyze the association between HRQoL and perceived support by parents of children with ASD.FindingsThe results showed that most participants (72.7%) were women aged 40. As many as 69.39% of participants had more than one child, and 16.33% declared they had other children who experienced the same problem (special needs children). This study indicated that the average health‐related quality of life score in children with ASD was 57.41 (9.418). The finding of this study showed a significant mean difference in HRQoL scores in children with ASD who received high institutional and family support compared to those who had low (p = 0.028, 95% confidence interval [CI] = −11.071 to 0.664).ConclusionInstitutional support positively impacts children with ASD's quality of life. Therefore, it is essential to improve the adequacy of support felt by families while caring for children with ASD.
Attachment as an intermediary variable between childhood maltreatment and perceived partner responsiveness in adolescents and young adults
Authors: Gosselin Carolyne , Daspe Marie‐Ève , Brassard Audrey , Lussier Yvan , Vaillancourt‐Morel Marie‐Pier 
Published: January 2024

AbstractCumulative childhood maltreatment (CCM) is associated with relationship difficulties including lower perceived partner responsiveness (PPR)—the degree of feeling cared for, understood, and validated by a person's partner. Attachment theory is understood via its representations of self and others and could offer a better understanding of how CCM effects continue into adulthood and affect PPR. We examined whether CCM is related to PPR via attachment in French‐speaking adolescents and young adults. A sample of 427 individuals in a romantic relationship and another sample of 159 couples completed self‐report measures. In both samples, a person's CCM was associated with their own lower PPR via their higher attachment anxiety and avoidance. In the dyadic sample, a person's CCM was associated with their partner's lower PPR via their own higher attachment anxiety. Attachment insecurities help understand the associations between CCM and PPR and may represent an important intervention target.
Community pharmacists' perceptions on managing people with oral health problems—A prioritisation survey
Authors: Jones Adam , Sturrock Andrew , Elliott Emma , Gussy Mark , Maidment Ian , Nelson David , Chew‐Graham Carolyn A. , Aggarwal Vishal R. 
Published: January 2024

AbstractBackgroundAlternative sources of oral health information are likely to be of benefit to the public, particularly where access to dental services is limited. There is evidence that community pharmacists are willing to advocate for oral health, but it is unclear what is needed to develop this role.ObjectivesThe aims of this study were to obtain the views of community pharmacy staff on the frequency and type of oral health conditions they encounter challenges in management and training/research priorities.MethodsAn anonymous online survey targeted pharmacy staff and elicited quantitative data related to the types and frequencies of oral health conditions experienced. Participants were stratified by age, gender, ethnicity, experience and setting. Free text responses allowed participants to detail challenging aspects of patient management, their priorities for service development and future research. Reflexive thematic analysis of free text responses identified key themes.ResultsOral/facial pain and swelling were seen weekly by most respondents, and daily by 28.8%. Other commonly presenting conditions were ulcers, dry‐mouth, thrush and denture issues. Challenges in managing oral health conditions included: access to NHS dentistry, awareness of referral pathways, examination/diagnosis and understanding ‘Red Flags’.ConclusionAcute and chronic oral health conditions commonly present to community pharmacists who lack necessary knowledge/training, which may result in missing ‘red flag’ symptoms for oral cancer or acute facial swellings which can be life threatening. There is a need to support pharmacists, who are willing to act as oral health advocates, in recognition, prevention and onward referral for oral diseases.
Co‐creating innovation ecosystems in contexts of absolute uncertainty: The case of low‐cost heart valves in India
Authors: Sahasranamam Sreevas , Soundararajan Vivek , Chatterjee Debabrata 
Published: January 2024

AbstractThe development of innovations aimed at tackling grand challenges requires the support of an appropriate innovation ecosystem. However, there is a limited understanding of how such innovation ecosystems emerge in contexts of absolute uncertainty. We addressed this gap by examining the boundary work carried out by key actors in the creation of the biomedical innovation ecosystem in India that supported the development of a successful low‐cost heart valve over the 1976–1995 period. We developed a process model demonstrating how the ecosystem leader co‐created the innovation ecosystem that led to the development of a low‐cost heart valve by engaging in three types of configuration boundary work: establishing ecosystem configuration, modeling ecosystem configuration, and expanding ecosystem configuration. Our study contributes to the literature on innovations for grand challenges, innovation ecosystems, and boundary work.
Health care for persons with intellectual and developmental disabilities in India
Authors: Mishra Amitav , Narayan Jayanthi 
Published: January 2024

AbstractLegislations for persons with disabilities emerged in the 1990s in India, providing them with rights and entitlements. Aligned with the UNCRPD, the Rights of Persons with Disabilities Act (2016) supports improved programmes and services. There are no exclusive policies for those with intellectual and developmental disabilities. Different government departments and non‐government organisations provide services including centrally sponsored programmes to persons with disabilities and enable them to exercise their rights. For example, rehabilitation and provision of aids and appliances lie with the Ministry of Social Justice and Empowerment, right to education is with the Ministry of Education, and, early intervention and health services and related supports are with the Ministry of Health. In India, non‐government organisations also play a vital role in health care services. In this paper, we discuss the existing health care systems including medical services in India for persons with disabilities with a specific focus on persons with intellectual and developmental disabilities. The discussion include how the system was evolved and what is in place today, the coverage, strengths, and limitations in the system. We have tried to provide a comprehensive description of existing policies, and practices of health care as well as the cultural influences with regard to health care for people with intellectual and developmental disabilities in India.
Patient reports of cancer care coordination in rural Hawaii
Authors: Okado Izumi , Liu Michelle , Elhajj Carry , Wilkens Lynne , Holcombe Randall F. 
Published: January 2024

AbstractPurposeRural residents experience disproportionate burdens of cancer, and poorer cancer health outcomes in rural populations are partly attributed to care delivery challenges. Cancer patients in rural areas often experience unique challenges with care coordination. In this study, we explored patient reports of care coordination among rural Hawaii patients with cancer and compared rural and urban patients’ perceptions of cancer care coordination.Methods80 patients receiving active treatment for cancer from rural Hawaii participated in a care coordination study in 2020–2021. Participants completed the Care Coordination Instrument, a validated oncology patient questionnaire.FindingsMean age of rural cancer patients was 63.0 (SD = 12.1), and 57.7% were female. The most common cancer types were breast and GI. Overall, rural and urban patients’ perceptions of care coordination were comparable (p > 0.05). There were statistically significant differences between rural and urban patients’ perceptions in communication and navigation aspects of care coordination (p = 0.02 and 0.04, respectively). Specific differences included a second opinion consultation, clinical trial considerations, and after‐hours care. 43% of rural patients reported traveling by air for part or all of their cancer treatment.ConclusionsFindings suggest that while overall perceptions of care coordination were similar between rural and urban patients, differential perceptions of specific care coordination areas between rural and urban patients may reflect limited access to care for rural patients. Improving access to cancer care may be a potential strategy to enhance care coordination for rural patients and ultimately address rural‐urban cancer health disparities.
Newborn and infant vision screening in primary care: A clinical review
Authors: Stocks Clare O. , Carson Rebecca A. 
Published: January 2024

AbstractPurposeNewborn and infant vision screening is an essential component of the health promotion visit, where the provider screens for ocular risk factors and abnormalities that may cause future impairment or vision loss. Providers may underestimate the importance of screening or find neonatal vision assessments difficult due to poor patient cooperation or time‐consuming exams, but the reversibility of vision impairment in infants makes early detection paramount to proper treatment. This article provides a clinical review of evidence‐based, practical guidance to providers who care for infants from birth through 6 months of age in the primary care setting.ConclusionsThe comprehensive eye exam in infants should include a thorough history and physical examination of eye structures, visual acuity, evaluation of extraocular movements and alignment, and assessment of the red reflex. Recommended exam maneuvers differ with age as visual acuity improves and development advances through infancy.Practice ImplicationsEarly detection of ocular pathology is critical to avoid permanent vision loss, serious morbidity, and even mortality. The seemingly complex vision screening exam can be completed with little to no cooperation from the patient when a competent pediatric healthcare provider prioritizes opportunistic exam maneuvers. The opportunistic exam allows providers to maximize efficiency while maintaining thorough technique during vision exams and screenings.
Periodontitis and postoperative inflammation in gastric cancer patients: Propensity score analysis
Authors: Sasaki Mio , Shigeishi Hideo , Nishi Hiromi , Hamada Natsuki , Kitasaki Honami , Yano Kanako , Kaneyasu Yoshino , Horikoshi Susumu , Kawaguchi Hiroyuki , Ohta Kouji 
Published: January 2024

AbstractObjectiveThe objective of this study was to clarify the association between preoperative periodontitis and postoperative systemic inflammation in patients with gastric cancer.Subjects and MethodsThis retrospective cohort study analyzed data from 140 gastric cancer patients who underwent surgery at Hiroshima University Hospital between May 2019 and May 2022. Periodontal inflamed surface area (PISA) scores were determined to assess periodontitis severity using modified Nesse's methods. Propensity score matching was used to compare patients with high and low PISA scores (> or < the median PISA score of 92.4, respectively). Propensity scores were calculated using a logistic regression model, based on 17 clinical parameters: age, sex, smoking, alcohol consumption, hypertension, diabetes, dyslipidemia, cardiovascular disease, stroke, clinical stage, surgical procedure, surgical approach, neoadjuvant chemotherapy, surgery duration, blood loss during surgery, remaining teeth, and denture use.ResultsThirty‐seven patients were propensity‐score‐matched. Participants with high PISA scores had a higher incidence of surgical site infection (10.5%) than those with low PISA scores (5.3%). Moreover, participants with high PISA scores had significantly higher C‐reactive protein levels on postoperative days 1 than those with low PISA scores.ConclusionPreoperative periodontitis may determine the level of postoperative systemic inflammation in patients with gastric cancer.
NEW PRODUCTS, NEW TASTES? AGRICULTURAL INNOVATIONS AND CONTINUITIES BETWEEN THE NINTH AND FOURTH CENTURIES BC IN MEDITERRANEAN IBERIA
Authors: Pérez‐Jordà Guillem , Peña‐Chocarro Leonor 
Published: January 2024

SummaryThe encounters between the immigrant populations of the Levant and the local communities of the south and east of the Iberian peninsula occurring from the beginning of the first millennium led to the transformation of diet and agricultural production. The arrival of new products such as chickpeas and different fruit trees, including in particular the vine, increased the variety and quality of the food consumed. It was at this specific moment that the so‐called ‘Mediterranean agricultural model’ was defined, upon which the identity of the different communities living in this territory was built.
Managing crises as if no one is watching? Governance dilemmas from a public perspective
Authors: Lenz Alexa 
Published: January 2024

AbstractIn the midst of ongoing crises, understanding how citizens perceive administrative crisis management is more relevant than ever. Combining organizational literature with insights from legitimacy research, this article scrutinizes how the public evaluates governance decisions concerning prominent crisis management dilemmas: flexibility versus stability, inclusion versus exclusion, and equity‐based versus needs‐based resource distribution. The paper argues that flexible, inclusive, and equity‐based governance decisions are generally perceived as more legitimate. However, governance decisions are also associated with adverse effects that can mitigate any initially positive effect on legitimacy. The argument is tested in a large‐scale randomized survey experiment in the context of a migration crisis, where governance decisions were manipulated. The findings support the expectations for inclusive crisis management and equity‐based resource distribution, which are perceived as the most legitimate governance alternatives. Internal adaptations of administrative practices toward more flexible and adaptive solutions, however, are perceived less legitimate than stable governmental action.
Versatile CYP98A enzymes catalyse meta‐hydroxylation reveals diversity of salvianolic acids biosynthesis
Authors: Zhou Zheng , Feng Jingxian , Huo Juncheng , Qiu Shi , Zhang Pan , Wang Yun , Li Qing , Li Yajing , Han Cuicui , Feng Xiaobing , Duan Yonghao , Chen Ruibin , Xiao Ying , He Ying , Zhang Lei , Chen Wansheng 
Published: January 2024

SummarySalvianolic acids (SA), such as rosmarinic acid (RA), danshensu (DSS), and their derivative salvianolic acid B (SAB), etc. widely existed in Lamiaceae and Boraginaceae families, are of interest due to medicinal properties in the pharmaceutical industries. Hundreds of studies in past decades described that 4‐coumaroyl‐CoA and 4‐hydroxyphenyllactic acid (4‐HPL) are common substrates to biosynthesize SA with participation of rosmarinic acid synthase (RAS) and cytochrome P450 98A (CYP98A) subfamily enzymes in different plants. However, in our recent study, several acyl donors and acceptors included DSS as well as their ester‐forming products all were determined in SA‐rich plants, which indicated that previous recognition to SA biosynthesis is insufficient. Here, we used Salvia miltiorrhiza, a representative important medicinal plant rich in SA, to elucidate the diversity of SA biosynthesis. Various acyl donors as well as acceptors are catalysed by SmRAS to form precursors of RA and two SmCYP98A family members, SmCYP98A14 and SmCYP98A75, are responsible for different positions' meta‐hydroxylation of these precursors. SmCYP98A75 preferentially catalyses C‐3′ hydroxylation, and SmCYP98A14 preferentially catalyses C‐3 hydroxylation in RA generation. In addition, relative to C‐3′ hydroxylation of the acyl acceptor moiety in RA biosynthesis, SmCYP98A75 has been verified as the first enzyme that participates in DSS formation. Furthermore, SmCYP98A enzymes knockout resulted in the decrease and overexpression leaded to dramatic increase of SA accumlation. Our study provides new insights into SA biosynthesis diversity in SA‐abundant species and versatility of CYP98A enzymes catalytic preference in meta‐hydroxylation reactions. Moreover, CYP98A enzymes are ideal metabolic engineering targets to elevate SA content.
Climate change adaptation in water law: International, EU and Finnish perspectives
Authors: Belinskij Antti , Soininen Niko , Puharinen Suvi‐Tuuli , Veijalainen Noora 
Published: January 2024

AbstractClimate change is expected to significantly alter hydrological regimes globally as well as locally. The impacts will encompass both long‐term changes in hydrological trends and short‐term extreme weather events. The need to anticipate and adapt to future changes will challenge legal rules and institutions, as these are bound to the past. This article analyses whether water law at international, EU and national (Finland) levels can deal with these hydrological changes. To this end, the analysis draws on a case study of the Finnish‐Russian transboundary Vuoksi River. We discuss the main substantive and procedural challenges of water law and outline some necessary legal changes. Our analysis shows that while water law at these levels includes some legal mechanisms for managing varying hydrological circumstances, these will prove insufficient in the light of the scale of anticipated hydrological changes.
The Impact of Flapping Trajectories on the Induced Thrust of a Single and Tandem Configuration Flapping Foil
Authors: Azad Duppala , Sunny Kumar A. , Ramana Menda Venkata , Swain Prafulla Kumar , Vadapalli Srinivas , Bommana Divakar 
Published: January 2024

Abstract
The development of propulsion devices by using the propulsive mechanisms of aquatic animals such as fish is a challenging task. An attempt has been made to replicate the fishtailed motion that caused thrust in the current investigation. At a low Reynolds number of Re = 1173, the propulsive performance of National Advisory Committee for Aeronautics 0012 flapping foils enduring distinct flapping trajectories (fishtailed and elliptical) is evaluated. A dynamic mesh arbitrary Lagrangian–Eulerian framework is used to understand the desired flapping motion of the foils while solving the flow via incompressible Navier–Stokes equations. Along with the flapping trajectory, the effects of the Strouhal number (St), inter-foils distance (Lx), and phase angle (φ) between the foils on the produced thrust are examined. The results demonstrate that using tandem configuration flapping foil with elliptical and fishtailed flapping can significantly increase the induced thrust and propulsive efficiency.
Analysis of Aerodynamic Loads on Heliostats at Operation Position Using Large Eddy Simulation and the Consistent Discrete Random Flow Generation Method
Authors: Durán R. L. , Hinojosa J. F. , Maytorena V. M. , Moreno S. 
Published: January 2024

Abstract
This study utilizes the large eddy simulation model (LES) and a synthetic method based on the Fourier technique called consistent discrete random flow generation (CDRFG) to analyze the peak aerodynamic loads on heliostats due to the atmospheric boundary layer. With the CDRFG technique, key flow parameters, including mean velocity profile, turbulent intensities, integral length scales, and turbulent spectra generated in wind tunnels, can be replicated while also satisfying the divergence-free condition. A three-facet heliostat with an elevation angle of α = 45 deg and the rear aligned to the inflow was analyzed. The heliostat behaves like a lifting surface in this orientation, accentuating the aerodynamic effect. The methodology proposed in this study can accurately reproduce flow statistics and predict the peak loads. Compared to experimental data, differences of 2.62% for drag, 7.43% for lift, and 11.0% for overturning were observed. Furthermore, the simulation reveals the generation of wingtip vortices on the sides of the heliostat, which contribute to the aerodynamic load. Overall, this technique has been demonstrated to be effective in replicating the atmospheric boundary layer and predicting the aerodynamic coefficients of heliostats.