bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming seed coat–imposed dormancy in wild species ofCajanusandRhynchosia
Authors: Lamichaney Amrit , Naik SJ Satheesh , Hazra Kali Krishna , Datta Dibendu , Parihar Ashok Kumar , Aidbhavi Revanasidda , Katiyar Pardip Kumar 
Published: October 2023

AbstractOccurrence of physical dormancy or hard seed coat prevents proper utilization and conservation of wild species ofCajanusandRhynchosia, which offers a source of many useful traits. Hence, an attempt has been made to understand the variability in hardseededness and the pretreatments (hot air treatment for 3, 5, 7, and 14 days; hot air treatment for 30 and 60 min; sulfuric acid scarification for 2 and 5 min; partial incision on seed coat) to overcome it in 44 accessions of 10 wild pigeon pea species. The level of hardseededness varied from 36% to 100% with an average of 76.5%. Likewise, time to 1% germination or time taken to initiate germination (T1), time to 50% germination (T50), and mean germination time (MGT) varied between 16.18–249.9 h, 94.7–607.7 h, and 37.5–153.2 h, respectively. Overall, all the treatments reduced hardseededness and improved germination over the control, with partial incision on seed coat being the best treatment for all the species recording 70%–98% germination, except forRhynchosia aurea(30%) andCajanus cajanifolius(59%). The hot water treatment for 30 and 60 min was the best treatment forC. cajanifoliusrecording germination of 66%–70% as compared to 11% in control. The sulfuric acid scarification for 2 min was the best pretreatment for overcoming dormancy and improving germination inRhynchosia bracteata,Rhynchosia rothii, andRhynchosia rufescens. The result indicated a significant inter‐ and intraspecific variation in the effectiveness of pretreatments in overcoming physical dormancy, suggesting that the optimum pretreatment for overcoming hardseededness should be standardized for each accession. Also, the dormancy‐breaking pretreatments not only reduced hardseededness and improved final germination percent but it also reduced time for T1, T50, and MGT, suggesting that use of such pretreatments before sowing could result into higher, uniform, and rapid germination.
Admixture mapping and selection scans identify genomic regions associated with stomatal patterning and disease resistance in hybrid poplars
Authors: Fetter Karl C. , Keller Stephen R. 
Published: October 2023

AbstractVariation in fitness components can be linked in some cases to variation in key traits. Metric traits that lie at the intersection of development, defense, and ecological interactions may be expected to experience environmental selection, informing our understanding of evolutionary and ecological processes. Here, we use quantitative genetic and population genomic methods to investigate disease dynamics in hybrid and non‐hybrid populations. We focus our investigation on morphological and ecophysiological traits which inform our understanding of physiology, growth, and defense against a pathogen. In particular, we investigate stomata, microscopic pores on the surface of a leaf that regulate gas exchange during photosynthesis and are sites of entry for various plant pathogens. Stomatal patterning traits were highly predictive of disease risk. Admixture mapping identified a polygenic basis of disease resistance. Candidate genes for stomatal and disease resistance map to the same genomic regions and experienced positive selection. Genes with functions to guard cell homeostasis, the plant immune system, components of constitutive defenses, and growth‐related transcription factors were identified. Our results indicate positive selection acted on candidate genes for stomatal patterning and disease resistance, potentially acting in concert to structure their variation in naturally formed backcrossing hybrid populations.
Biome‐ and timescale‐dependence of Holocene vegetation variability in the Northern Hemisphere
Authors: Hébert Raphaël , Schild Laura , Laepple Thomas , Herzschuh Ulrike 
Published: October 2023

AbstractGlobal climatic changes expected in the next centuries are likely to cause unparalleled vegetation disturbances, which in turn impact ecosystem services. To assess the significance of disturbances, it is necessary to characterize and understand typical natural vegetation variability on multi‐decadal timescales and longer. We investigate this in the Holocene vegetation by examining a taxonomically harmonized and temporally standardized global fossil pollen dataset. Using principal component analysis, we characterize the variability in pollen assemblages, which are a proxy for vegetation composition, and derive timescale‐dependent estimates of variability using the first‐order Haar structure function. We find, on average, increasing fluctuations in vegetation composition from centennial to millennial timescales, as well as spatially coherent patterns of variability. We further relate these variations to pairwise comparisons between biome classes based on vegetation composition. As such, higher variability is identified for open‐land vegetation compared to forests. This is consistent with the more active fire regimes of open‐land biomes fostering variability. Needleleaf forests are more variable than broadleaf forests on shorter (centennial) timescales, but the inverse is true on longer (millennial) timescales. This inversion could also be explained by the fire characteristics of the biomes as fire disturbances would increase vegetation variability on shorter timescales, but stabilize vegetation composition on longer timecales by preventing the migration of less fire‐adapted species.
Functional consequences of animal community changes in managed grasslands: An application of the CAFE approach
Authors: Hogan Katharine F. E. , Jones Holly P. , Savage Kirstie , Burke Angela M. , Guiden Peter W. , Hosler Sheryl C. , Rowland‐Schaefer Erin , Barber Nicholas A. 
Published: October 2023

AbstractIn the midst of an ongoing biodiversity crisis, much research has focused on species losses and their impacts on ecosystem functioning. The functional consequences (ecosystem response) of shifts in communities are shaped not only by changes in species richness, but also by compositional shifts that result from species losses and gains. Species differ in their contribution to ecosystem functioning, so species identity underlies the consequences of species losses and gains on ecosystem functions. Such research is critical to better predict the impact of disturbances on communities and ecosystems. We used the “Community Assembly and the Functioning of Ecosystems” (CAFE) approach, a modification of the Price equation to understand the functional consequences and relative effects of richness and composition changes in small nonvolant mammal and dung beetle communities as a result of two common disturbances in North American prairie restorations, prescribed fire and the reintroduction of large grazing mammals. Previous research in this system has shown dung beetles are critically important decomposers, while small mammals modulate much energy in prairie food webs. We found that dung beetle communities were more responsive to bison reintroduction and prescribed fires than small nonvolant mammals. Dung beetle richness increased after bison reintroduction, with higher dung beetle community biomass resulting from changes in remaining species (context‐dependent component) rather than species turnover (richness components); prescribed fire caused a minor increase in dung beetle biomass for the same reason. For small mammals, bison reintroduction reduced energy transfer through the loss of species, while prescribed fire had little impact on either small mammal richness or energy transfer. The CAFE approach demonstrates how bison reintroduction controls small nonvolant mammal communities by increasing prairie food web complexity, and increases dung beetle populations with possible benefits for soil health through dung mineralization and soil bioturbation. Prescribed fires, however, have little effect on small mammals and dung beetles, suggesting a resilience to fire. These findings illustrate the key role of re‐establishing historical disturbance regimes when restoring endangered prairie ecosystems and their ecological function.
Numerical multiscale analysis of 3D printed short fiber composites parts: Filament anisotropy and toolpath effects
Authors: Estefani Alejandro , Távara Luis 
Published: October 2023

AbstractThe aim of the present investigation is the development of a numerical model able to adequately represent the effect of several variables, associated to the fused deposition modeling (FDM) procedure, on the mechanical behavior of 3D printed parts. Specifically, 3D printed carbon short‐fiber reinforced thermoplastic parts are numerically analyzed. Previous experimental results have proven that this kind of parts show a global anisotropic behavior, in terms of classical mechanical parameters as stiffness. Thus, special emphasis is done in analyzing the effect of the raster angle / toolpath (inherent to FDM) and the internal microstructure of the deposited filaments (due to the presence of the short fibers). Multiscale finite element models are used to represent the linear elastic behavior at macro scale. The numerical models are also able to include the effect of porosity. Based on experimental results of 3D printed composite parts with 100% infill and different raster angles, elastic transversely isotropic properties are estimated for the individual deposited filaments using a reverse engineering procedure. Obtained results show that for an adequate modeling of FDM composite parts, anisotropic properties of the filament must be taken into account, even when quasi‐isotropic printing parameters are used (“cross‐ply” configurations). Finally, additional numerical analyses of some parameters associated to the FDM technique are done. Specifically, the effect of porosity related to the infill pattern and percentage on the global (macro) apparent stiffness is analyzed.
Elastic functional changepoint detection of climate impacts from localized sources
Authors: Tucker J. Derek , Yarger Drew 
Published: October 2023

AbstractDetecting changepoints in functional data has become an important problem as interest in monitoring of climate phenomenon has increased, where the data is functional in nature. The observed data often contains both amplitude (‐axis) and phase (‐axis) variability. If not accounted for properly, true changepoints may be undetected, and the estimated underlying mean change functions will be incorrect. In this article, an elastic functional changepoint method is developed which properly accounts for these types of variability. The method can detect amplitude and phase changepoints which current methods in the literature do not, as they focus solely on the amplitude changepoint. This method can easily be implemented using the functions directly or can be computed via functional principal component analysis to ease the computational burden. We apply the method and its nonelastic competitors to both simulated data and observed data to show its efficiency in handling data with phase variation with both amplitude and phase changepoints. We use the method to evaluate potential changes in stratospheric temperature due to the eruption of Mt. Pinatubo in the Philippines in June 1991. Using an epidemic changepoint model, we find evidence of a increase in stratospheric temperature during a period that contains the immediate aftermath of Mt. Pinatubo, with most detected changepoints occurring in the tropics as expected.
Expert opinion on diagnosis and management of epilepsy‐associated comorbidities
Authors: Peltola Jukka , Surges Rainer , Voges Berthold , von Oertzen Tim J. 
Published: October 2023

AbstractApart from seizure freedom, the presence of comorbidities related to neurological, cardiovascular, or psychiatric disorders is the largest determinant of a reduced health‐related quality of life in people with epilepsy (PwE). However, comorbidities are often underrecognized and undertreated, and clinical management of comorbid conditions can be challenging. The focus of a comprehensive treatment regimen should maximize seizure control while optimizing clinical management of treatable comorbidities to improve a person's quality of life and overall health. A panel of four European epileptologists with expertise in their respective fields of epilepsy‐related comorbidities combined the latest available scientific evidence with clinical expertise and collaborated to provide consensus practical advice to improve the identification and management of comorbidities in PwE. This review provides a critical evaluation for the diagnosis and management of sleep–wake disorders, cardiovascular diseases, cognitive dysfunction, and depression in PwE. Whenever possible, clinical data have been provided. The PubMed database was the main search source for the literature review. The deleterious pathophysiological processes underlying neurological, cardiovascular, or psychiatric comorbidities in PwE interact with the processes responsible for generating seizures to increase cerebral and physiological dysfunction. This can increase the likelihood of developing drug‐resistant epilepsy; therefore, early identification of comorbidities and intervention is imperative. The practical evidence‐based advice presented in this article may help clinical neurologists and other specialist physicians responsible for the care and management of PwE.
Contaminants of Concern and Spatiotemporal Metabolomic Changes in Quagga Mussels (Dreissena bugensis rostriformis) from the Milwaukee Estuary (Wisconsin, USA)
Authors: Fuller Neil , Kimbrough Kimani L. , Davenport Erik , Edwards Michael E. , Jacob Annie , Chandramouli Bharat , Johnson W. Edward 
Published: October 2023

Abstract
Environmental metabolomics has emerged as a promising technique in the field of biomonitoring and as an indicator of aquatic ecosystem health. In the Milwaukee Estuary (Wisconsin, USA), previous studies have used a nontargeted metabolomic approach to distinguish between zebra mussels (Dreissena polymorpha) collected from sites of varying contamination. To further elucidate the potential effects of contaminants on bivalve health in the Milwaukee Estuary, the present study adopted a caging approach to study the metabolome of quagga mussels (Dreissena bugensis rostriformis) deployed in six sites of varying contamination for 2, 5, or 55 days. Caged mussels were co-deployed with two types of passive sampler (polar organic chemical integrative samplers and semipermeable membrane devices) and data loggers. In conjunction, in situ quagga mussels were collected from the four sites studied previously and analyzed for residues of contaminants and metabolomics using a targeted approach. For the caging study, temporal differences in the metabolomic response were observed with few significant changes observed after 2 and 5 days, but larger differences (up to 97 significantly different metabolites) to the metabolome in all sites after 55 days. A suite of metabolic pathways were altered, including biosynthesis and metabolism of amino acids, and upmodulation of phospholipids at all sites, suggesting a potential biological influence such as gametogenesis. In the caging study, average temperatures appeared to have a greater effect on the metabolome than contaminants, despite a large concentration gradient in polycyclic aromatic hydrocarbons residues measured in passive samplers and mussel tissue. Conversely, significant differences between the metabolome of mussels collected in situ from all three contaminated sites and the offshore reference site were observed. Overall, these findings highlight the importance of contextualizing the effects of environmental conditions and reproductive processes on the metabolome of model organisms to facilitate the wider use of this technique for biomonitoring and environmental health assessments. Environ Toxicol Chem 2024;43:307–323. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Homo heterogenus: Variability in early Pleistocene Homo environments
Authors: Foister Tegan I. F. , Žliobaitė Indrė , Wilson Oscar E. , Fortelius Mikael , Tallavaara Miikka 
Published: October 2023

AbstractTo understand the ecological dominance of Homo sapiens, we need to investigate the origins of the plasticity that has enabled our colonization of the planet. We can approach this by exploring the variability of habitats to which different hominin populations have adapted over time. In this article, we draw upon and synthesize the current research on habitats of genus Homo during the early Pleistocene. We examined 121 published environmental reconstructions from 74 early Pleistocene sites or site phases to assess the balance of arguments in the research community. We found that, while grasslands and savannahs were prominent features of Homo habitats in the early Pleistocene, current research does not place early Pleistocene Homo, in any single environmental type, but in a wide variety of environments, ranging from open grasslands to forests. Our analysis also suggests that the first known dispersal of Homo out of Africa was accompanied by niche expansion.
Association between atherosclerosis and primary Sjogren's syndrome: A cross‐sectional study
Authors: Liu Shuang , Li Xingjun , Yang Qian , Wang Nan , Xu Jian , Li Luqiong , Guo Yulong 
Published: October 2023

AbstractBackground and AimsAtherosclerosis (AS) risk increases in patients with systemic autoimmune diseases. The association and mechanism between primary Sjogren's syndrome (pSS) and AS haven't been explained for now. We did this cross‐sectional study to clarify the prevalence and risk factors of AS in patients with pSS, and to further explore how immune cells and inflammatory cytokines work in the process.MethodsPatients with pSS were enrolled. General information, AS events, immune cells, inflammatory cytokines, and related clinical data were recorded. Prevalence of AS events was calculated. Correlation analysis between immune factors and AS quantitative parameters were conducted by SPSS v20.0.ResultsA total of 155 pSS patients were included with a median Framingham 10‐year risk of 7%. Sixty‐four AS events were recorded, with a prevalence of 41.3%. Carotid intima‐media thickness was positively correlated to immunoglobulin (Ig) A (r = 0.245, p = 0.030) and negatively correlated to IgM (r = −0.227, p = 0.045). Left ankle‐brachial pulse wave velocity (baPWV) was positively correlated to the course of disease (r = 0.352, p = 0.004), B cells (r = 0.410, p = 0.001), and T helper (Th) cells (r = 0.284, p = 0.029), while negatively correlated to IgM (r = −0.257, p = 0.042). Right baPWV was positively correlated to the course of pSS (r = 0.319, p = 0.010), B cells (r = 0.453, p < 0.001), Th cells (r = 0.302, p = 0.020), and C‐reactive protein (CRP) (r = 0.286, p = 0.042). Use of hydroxychloroquine, cyclophosphamide, and glucocorticoids had no impact on AS events.ConclusionThe prevalence of AS in patients with pSS is reported to be 41.3%. Several risk factors have been associated with AS in these patients, including the duration of the disease, levels of Th cells, B lymphocytes, and CRP. Interestingly, IgM appears to have a protective effect against AS. It is worth noting that traditional therapy for pSS does not seem to have any effect in preventing AS events.
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Authors: Xiao Yao , Liu Yi‐Feng , Li Hong‐Wei , Li Jia‐Yang , Wang Jing‐Qiang , Hu Hai‐Yan , Su Yu , Jian Zhuang‐Chun , Yao Hu‐Rong , Chen Shuang‐Qiang , Zeng Xian‐Xiang , Wu Xiong‐Wei , Wang Jia‐Zhao , Zhu Yan‐Fang , Dou Shi‐Xue , Chou Shu‐Lei 
Published: October 2023

AbstractIn the article (DOI: 10.1002/inf2.12475), Yao Xiao and co‐workers report an oxide cathode material of Na0.6Mn0.95Mg0.05O2 with layered/tunnel intergrowth structure, which exhibits superior Na+ storage performance, offering new opportunities for realizing high‐energy‐density and long‐cycle‐life sodium‐ion batteries.
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Invasive Pharmacodynamic Characterization of Combined Ibopamine and Calcium Blocker Therapy for Heart Failure
Authors: Munger Mark A. , Nara Andrew R. , Pospisil Robert A. , Stoddard Gregory J. , Schleman Margo 
Published: October 2023

Study Objective. To determine the acute hemodynamic response of single‐dose coadministration of ibopamine plus nifedipine or diltiazem in patients with New York Heart Association functional class (NYHA FC) II—III congestive heart failure.Design. A single‐blind, placebo‐controlled, two‐paired, crossover study.Setting. Cardiology clinics at two large teaching hospitals.Patients. Eight patients with NYHA FC II—III congestive heart failure who met the inclusion criteria were selected randomly.Interventions. All patients underwent right heart catheterization. Day 1 consisted of concomitant calcium channel blocker plus placebo, with cardiac and peripheral hemodynamic recordings from 30 minutes–24 hours. The design was equivalent on day 2, with single‐dose administration of ibopamine plus calcium channel blocker.Measurements and Main Results. Single‐dose nifedipine‐diltiazem augmented cardiac output and stroke volume secondary to decreasing systemic vascular resistance. The nifedipine‐ibopamine and diltiazem‐ibopamine subgroups demonstrated relatively equal hemodynamics, augmenting cardiac index (nifedipine 43%, p<0.05; diltiazem 40%, p<0.05 vs baseline) while decreasing systemic vascular resistance (nifedipine 41%, p<0.05; diltiazem 28%, p NS vs baseline) 30 minutes after the dose. In contrast to single‐dose diltiazem, the diltiazem‐ibopamine subgroup exhibited an increased left ventricular filling pressure (122%, p<0.05 vs baseline) and mean pulmonary artery pressure (43%, p<0.05 vs baseline) at 30 minutes after the dose. One patient experienced a transient episode of chest pain associated with increased heart rate and blood pressure with diltiazem‐ibopamine.Conclusion. Diltiazem and ibopamine should be coadministered with caution in patients with coronary artery disease and left ventricular dysfunction.