bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Trends in Computer-aided Drug Design for Anti-cancer Drug
Discovery
Authors: Tur Razia Iashia , Kanwal Ayesha , Riaz Hafiza Fatima , Malik Abbeha , Ahsan Muhammad , Saleem Khan Muhammad , Raza Ali , Sabir Sumera , Sajid Zureesha , Fardeen Khan Muhammad , Tahir Rana Adnan , Arslan Sehgal Sheikh 
Published: November 2023

Abstract:
Cancer is considered one of the deadliest diseases globally, and continuous research is
being carried out to find novel potential therapies for myriad cancer types that affect the human
body. Researchers are hunting for innovative remedies to minimize the toxic effects of conventional
therapies being driven by cancer, which is emerging as pivotal causes of mortality worldwide.
Cancer progression steers the formation of heterogeneous behavior, including self-sustaining proliferation,
malignancy, and evasion of apoptosis, tissue invasion, and metastasis of cells inside the
tumor with distinct molecular features. The complexity of cancer therapeutics demands advanced
approaches to comprehend the underlying mechanisms and potential therapies. Precision medicine
and cancer therapies both rely on drug discovery. In vitro drug screening and in vivo animal trials
are the mainstays of traditional approaches for drug development; however, both techniques are laborious
and expensive. Omics data explosion in the last decade has made it possible to discover efficient
anti-cancer drugs via computational drug discovery approaches. Computational techniques
such as computer-aided drug design have become an essential drug discovery tool and a keystone
for novel drug development methods. In this review, we seek to provide an overview of computational
drug discovery procedures comprising the target sites prediction, drug discovery based on
structure and ligand-based design, quantitative structure-activity relationship (QSAR), molecular
docking calculations, and molecular dynamics simulations with a focus on cancer therapeutics.
The applications of artificial intelligence, databases, and computational tools in drug discovery
procedures, as well as successfully computationally designed drugs, have been discussed to highlight
the significance and recent trends in drug discovery against cancer. The current review describes
the advanced computer-aided drug design methods that would be helpful in the designing
of novel cancer therapies.
Combination of Multiple MRI Parameters Related to Signal Intensity and
Volume for Predicting Response to Neoadjuvant Chemoradiotherapy by
Patients with Locally Advanced Rectal Cancer
Authors: Tan Zhengwu , Xie Lingling , Cheng Lan , Lin Zhenyu , Zhang Lan , Han Ping , Li Xin 
Published: November 2023

Background::
MRI of patients with locally advanced rectal cancer (LARC) can predict the pathological complete response (pCR) to preoperative chemoradiation
therapy (CRT). Our purpose was to use MRI results to evaluate the diagnostic value of combined changes in signal intensity (SI) and volume (V)
of patients with LARC for predicting pCR to CRT.

Methods::
This retrospective study on 100 patients with LARC analyzed clinical and imaging data that were collected from March, 2018, to March, 2020.
Before and after CRT, T2-weighted (T2W), apparent diffusion coefficient (ADC), and contrast-enhanced T1-weighted (ceT1W) data were
analyzed. Percent changes of V (%ΔV) and relative SI ratio (%ΔSIR) on different sequences were calculated. After CRT, patients had pathological
confirmation as pCR or non-pCR. Data were analyzed using nonparametric tests and receiver operating characteristic (ROC) analysis.

Results::
There were 34 pCR and 66 non-pCR patients. Except for ADC-%ΔSIR, the combined parameters and single parameters had a greater decrease in
the pCR group. The combination of ADC-%ΔV and T2W-%ΔSIR had the greatest diagnostic value (AUC=0.85,cutoff=0.23%) and the
combination of ADC-%ΔV% and ΔSIR had the best accuracy (89%, cutoff=44.11%). Except for T2W-%ΔV and T2W-%ΔSIR, the different
sequences had moderate differences in diagnostic performance. The diagnostic performance of combined parameters or single parameters on ADC
and T2W was significantly better than those on ceT1W (p<0.01).

Conclusion::
All sequences except ADC-%ΔSIR provided reliable predictions of pCR, although ceT1W data had limited usefulness.
The Significance of Contrast-enhanced Ultrasound in the Application of
Lymphaticovenous Anastomosis
Authors: Xiahou Yu , Yuan Xinchun , Zhu Jia , Hu Weihong , Zhang Lili 
Published: November 2023

Background::
Lymphaticovenous anastomosis (LVA) surgery is an effective treatment for lymphedema. Accurate evaluation and localization of the superficial
lymphatic vessels before the operation is crucial for the success of the operation. Contrast-enhanced ultrasound (CEUS) is a new ultrasound
technology, and its clinical application value in LVA surgery has not been established.

Objective::
This study aimed to assess the efficacy of CEUS in LVA surgery and provide a novel approach for the clinical assessment and localization of
superficial lymphatic vessels.

Methods::
Retrospective analysis of imaging and surgical data was performed on 20 LVA patients. Among them, 10 cases underwent evaluation and
localization using indocyanine green (ICG) lymphatic imaging (Group A), while 10 cases were evaluated and localized using CEUS (Group B).
The differences in surgical data between the two groups were compared and analyzed.

Results::
All 20 patients were female (mean age, 57.7 years ± 6.3 [SD]). CEUS demonstrated superior visualization and localization of superficial lymphatic
vessels. The average diameter of lymphatic vessels identified in the CEUS group was significantly greater than that in the ICG group (0.78±0.06
vs. 0.52±0.05mm; P<0.001). The duration of operation in group B was significantly shorter than that in group A (4.47±0.37 vs. 6.70±0.45mm;
P<.001). The number of anastomosed lymphatic vessels in group B was less than that in group A [5.0(4.0, 6.0) vs. 9.5 (9.0, 11.3); P<0.001].

Conclusion::
CEUS can serve as a viable alternative to ICG lymphatic imaging, facilitating improved lymphatic venous anastomosis surgery
Chronic Inorganic Nitrate Administration Increases the Expression
of Genes Involved in the Browning of Gonadal Adipose Tissue in
Ovariectomized Rats
Authors: Yousefzadeh Nasibeh , Jeddi Sajad , Ghasemi Asghar 
Published: November 2023

Background and Objective::
Nitrate, as nitric oxide (NO) donor, has been suggested
as a nutrition-based treatment for decreasing the risk of menopause-related obesity. This study
aimed to specify the effects of chronic inorganic nitrate administration on uncoupling protein-1
(UCP-1), peroxisome proliferator-activated-receptor-γ (PPAR-γ) coactivator-1α (PGC-1α), and
PPAR-γ expression in gonadal adipose tissue (GAT) of ovariectomized (OVX) rats.

Methods::
Female rats were assigned to 3 groups: Control, OVX, and OVX+nitrate (n=7/group),
which consumed water containing inorganic nitrate (100 mg/L) for 9 months. At month 9, GAT
was used for the measurement of NO metabolites (NOx), mRNA levels of NO synthases (endothelial
(eNOS), inducible (iNOS), neuronal (nNOS)), and mRNA and protein levels of UCP-1,
PGC-1α, and PPAR-γ.

Result::
OVX rats had lower NOx concentration (45%) and eNOS (38%) and nNOS (30%) expression
in GAT that was restored to normal values following nitrate administration. OVX rats
had significantly lower mRNA and protein levels of UCP-1 (83% and 30%), PGC-1α (65% and
39%), and PPAR-γ (66% and 34.5%) in GAT. Chronic inorganic nitrate administration in OVXrats
increased mRNA and protein levels of UCP-1 (128% and 34%), PGC-1α (115% and 43%),
and PPAR-γ (236% and 38%), respectively.

Conclusion::
In OVX rats, chronic nitrate administration increased gene and protein levels of
UCP-1, PGC-1α, and PPAR-γ in GAT, indicating the anti-obesity effects of nitrate are partially
mediated by the white adipose tissue (WAT) browning. Moreover, the stimulatory effect of inorganic
nitrate on the WAT browning in OVX rats was associated with blunting the OVXinduced
NO deficiency in GAT.
Design, Fabrication and Performance Test of an Effective Body Armor
Authors: Rahman Muhammad Ashiqur , Tawsif Ur Rauf  , Ibrahim Md. Sikander 
Published: November 2023

Aims:
This original research paper targets an easy but efficient design and fabrication of
a safe body armor. A test bed with weapons was another key aim. Therefore, it is essential to verify
the vest’s capability to withstand rigorous stab tests as prescribed by the standard.

Background:
The most widely used armor piece is the torso-protecting overt (worn over the uniform
or clothing) one. The main concern of this work was to design and develop such a stabresistant
soft body armor made from readily available materials to protect against threats such as
knives, blades, and sharp-tipped objects.

Objectives:
From the Mechanical Engineering point of view, the present research goals for such an
armor vest were: low cost, moderately lightweight, comfortable, made from easily available materials,
simple forward design, easy to fabricate, and the ability to adjust the level of protection without
altering the primary design structure. The effectiveness of the vest needed to be verified through
rigorous testing following relevant standards.

Methods:
The prototype of the stab-resistant armor was fabricated with two different configurations
and their performance was rigorously tested in accordance with the NIJ Standard-0115.00 to
determine its level of protection. Nylon-based panel elements covered with rubber and cotton-based
panels were compared in terms of their ability to stop stab threats. Taking into account the key
point of strike energy levels during the stabbing, test beds were created in the laboratory to rigorously
conduct the required tests. Blades of two types were made, attached with fixtures, and
dropped on the armors (upon backing material) in the test bed.

Results:
The ‘Complete Armor’ showed excellent performance against stab attacks. The tests revealed
that the nylon-based panel elements covered with rubber were more successful in stopping
stab threats compared to cotton-based panels.

Conclusion:
The designed and fabricated prototype of the stab-resistant soft body armor achieved
the desired level of protection against stab threats. The armor is also cost-effective, it can be fabricated
using locally available materials, at a cost of only 10 USD compared to 300 USD for commercially
available armor.

Other:
However, it should be noted that stab resistance does not necessarily imply ballistic resistance,
and no armor can provide invincibility against all types of threats.
Uncovering Language Disparity of ChatGPT on Retinal Vascular Disease Classification: Cross-Sectional Study
Authors: Liu Xiaocong , Wu Jiageng , Shao An , Shen Wenyue , Ye Panpan , Wang Yao , Ye Juan , Jin Kai , Yang Jie 
Published: November 2023

Background
Benefiting from rich knowledge and the exceptional ability to understand text, large language models like ChatGPT have shown great potential in English clinical environments. However, the performance of ChatGPT in non-English clinical settings, as well as its reasoning, have not been explored in depth.

Objective
This study aimed to evaluate ChatGPT’s diagnostic performance and inference abilities for retinal vascular diseases in a non-English clinical environment.

Methods
In this cross-sectional study, we collected 1226 fundus fluorescein angiography reports and corresponding diagnoses written in Chinese and tested ChatGPT with 4 prompting strategies (direct diagnosis or diagnosis with a step-by-step reasoning process and in Chinese or English).

Results
Compared with ChatGPT using Chinese prompts for direct diagnosis that achieved an F1-score of 70.47%, ChatGPT using English prompts for direct diagnosis achieved the best diagnostic performance (80.05%), which was inferior to ophthalmologists (89.35%) but close to ophthalmologist interns (82.69%). As for its inference abilities, although ChatGPT can derive a reasoning process with a low error rate (0.4 per report) for both Chinese and English prompts, ophthalmologists identified that the latter brought more reasoning steps with less incompleteness (44.31%), misinformation (1.96%), and hallucinations (0.59%) (all P<.001). Also, analysis of the robustness of ChatGPT with different language prompts indicated significant differences in the recall (P=.03) and F1-score (P=.04) between Chinese and English prompts. In short, when prompted in English, ChatGPT exhibited enhanced diagnostic and inference capabilities for retinal vascular disease classification based on Chinese fundus fluorescein angiography reports.

Conclusions
ChatGPT can serve as a helpful medical assistant to provide diagnosis in non-English clinical environments, but there are still performance gaps, language disparities, and errors compared to professionals, which demonstrate the potential limitations and the need to continually explore more robust large language models in ophthalmology practice.
mHealth Technology Experiences of Middle-Aged and Older Individuals With Visual Impairments: Cross-Sectional Interview Study
Authors: Choi Soyoung , Sajib Md Refat Uz Zaman , Manzano Jenna , Chlebek Christian Joseph 
Published: November 2023

Background
Current mobile health (mHealth) technology is predominantly designed with a visual orientation, often resulting in user interfaces that are inaccessible to visually impaired users. While mHealth technology offers potential for facilitating chronic illness management and enhancing health behaviors among visually impaired older populations, understanding its usage remains limited.

Objective
This qualitative research aimed to explore the mHealth technology experiences of middle-aged and older individuals with visual impairments including the accessibility and usability issues they faced.

Methods
The qualitative exploration was structured using the mHealth for Older Users framework. Cross-sectional interviews were conducted via Zoom between June 1 and July 31, 2023, using an interview protocol for data collection. A thematic analysis approach was employed to analyze the transcribed interview scripts.

Results
Of the 7 participants who took part in the Zoom interviews, 3 were men and 4 were women, with ages ranging from 53 to 70 years. Most participants adopted mHealth apps and wearable devices for promoting health. They exhibited 3 distinct adoption patterns. Seven themes were emerged from the perceived challenges in using mHealth technologies: (1) a scarcity of accessible user manuals, (2) user interfaces that are not visually impaired-friendly, (3) health data visualizations that are not accessible, (4) unintuitive arrangement of app content, (5) health information that is challenging to comprehend, (6) cognitive overload caused by an excess of audible information, and (7) skepticism regarding the accuracy of health records. mHealth technologies seem to positively affect the health and health management of participants.

Conclusions
Design considerations for mHealth technologies should consider individuals’ disabilities and chronic conditions and should emphasize the importance of providing accessible manuals and training opportunities when introducing new mHealth solutions.
Pengolahan koleksi di Taman Baca Masyarakat Karya Mulya Kota Palembang dalam upaya meningkatkan temu kembali informasi
Authors: Yoanda Sely , Gunaidi Aang 
Published: November 2023

Introduction. The number of collections at the Karya Mulya Community Reading Center or Taman Bacaan Masyarakat (TBM) Palembang City continue to increase. It is necessary to evaluate the collection the efficient collection management that will influence information retrieval and increase public interest in reading.
Data Collection Methods. This study used a qualitative research method with a descriptive approach.
Data Analysis. The data analysis was conducted descriptively through several stages including data reduction, data presentation, and conclusion/data verification.
Results and Discussion. TBM Karya Mulya Palembang City has not carried out a systematic collection processing. The current stages of collection processing at TBM Karya Mulya Palembang City consist of inventorying, classifying children, adolescents and adults reading books, stamping collections, and shelving. This evaluation in a collection processing model at TBM Karya Mulya Palembang City lead to the better collection management based on library collection processing standards.
Conclusion. The TBM collection processing model of Karya Mulya Palembang City can be a reference in collection processing to facilitate information retrieval.
Associations of Changes in Bone Turnover Markers with Change in Bone Mineral Density in Kidney Transplant Patients
Authors: Jørgensen Hanne Skou , Claes Kathleen , Smout Dieter , Naesens Maarten , Kuypers Dirk , D'Haese Patrick , Cavalier Etienne , Evenepoel Pieter 
Published: November 2023

Background
Bone loss after kidney transplantation is highly variable. We investigated whether changes in bone turnover markers associate with bone loss during the first post-transplant year.

Methods
Bone mineral density (BMD) was measured at 0 and 12 months, with biointact parathyroid hormone, bone-specific alkaline phosphatase (BALP), intact procollagen type I N-terminal propeptide (PINP), and tartrate-resistant acid phosphatase isoform 5b (TRAP5b) measured at 0, 3, and 12 months post-transplant (N=209). Paired transiliac bone biopsies were available in a subset (n=49). Between-group differences were evaluated by Student's t test, Wilcoxon signed-rank test, or Pearson's chi-squared test.

Results
Changes in BMD varied from –22% to +17%/yr. Compared with patients with no change (±2.5%/yr), patients who gained BMD had higher levels of parathyroid hormone (236 versus 136 pg/ml), BALP (31.7 versus 18.8 μg/L), and Intact PINP (121.9 versus 70.4 μg/L) at time of transplantation; a greater decrease in BALP (−40% versus −21%) and Intact PINP (−43% versus −13%) by 3 months; and lower levels of Intact PINP (36.3 versus 60.0 μg/L) at 12 months post-transplant. Patients who lost BMD had a less marked decrease, or even increase, in Intact PINP (+22% versus −13%) and TRAP5b (−27% versus −43%) at 3 months and higher Intact PINP (83.7 versus 60.0 μg/L) and TRAP5b (3.89 versus 3.16 U/L) at 12 months compared with patients with no change. If none of the biomarkers decreased by the least significant change at 3 months, an almost two-fold (69% versus 36%) higher occurrence of bone loss was seen at 12 months post-transplant.

Conclusions
Bone loss after kidney transplantation was highly variable. Resolution of high bone turnover, as reflected by decreasing bone turnover markers, associated with BMD gain, while increasing bone turnover markers associated with bone loss.
Effectiveness of project-based learning for enhancing students critical thinking skills: A meta-analysis
Authors: Tafakur Tafakur , Retnawati Heri , Shukri Ahmad Adnan Mohd 
Published: November 2023

Innovative learning models like Project-based learning are believed to encourage not only the achievement of student learning outcomes but also 21st-century skills. Many studies on Project-based learning are related to developing 21st-century skills, one of which is critical thinking, with different results. Therefore, it is necessary to conduct a study that can elaborate on various studies on the effectiveness of Project-based learning on students' thinking skills. This study aims to determine the difference in critical thinking skills between students participating in project-based learning and other models. This study uses a quantitative approach with meta-analysis. The data is secondary data from studies published in journal articles indexed by Scopus and Google Scholar in the last ten years with a total of 29 studies that are suitable for analysis. The estimated aggregate is the difference between groups. Data analysis used Comprehensive Meta-Analysis Vers.3 to calculate and estimate aggregates, draw forest plots, test hypotheses, and analyze biases. The analysis results show that Project-based learning promotes students' critical thinking skills, although moderated by education level and comparative learning strategies. Project-based learning is superior to traditional learning at various levels of education. Project-based learning and other scientific learning are known to support students' critical thinking skills. Teachers can also make PjBL more innovative by utilizing information technology, and the contextual environment, as well as integrating various media, content, and other learning strategies to encourage student critical thinking skills.
Traditional Medicine Use Among HIV Positive Patients in Markurdi, Benue State of Nigeria
Authors: Akunne Maureen , Emerenini Chinenye , Anetoh Maureen , Okonta Eleje 
Published: November 2023

Background: Traditional medicine (TM) is a collection of skills, knowledge, and practices based on theories, beliefs, and experiences from various cultures that are used to maintain health as well as to prevent, diagnose, improve, or treat physical and mental disorders. There exist a number of non-conventional medicines practices in the world today. Limited documented data exist that addressed the use of traditional medicines among HIV patients in Nigeria.
Objectives: To assess the use and the pattern of use of traditional medicines among HIV positive patients.
Methods: This study was a cross sectional, descriptive study carried out at the Federal Medical Center Makurdi, Benue State, middle belt, Nigeria for a period of three months.
Results: In this study, nearly two-thirds (61.7%) of the participants reported that they had never used Traditional Medicine (TM) along with HIV/AIDS drugs and 16.1% reported that they began TM use after the initiation of ART. The leading forms of TM used by the patients were spiritual therapy (21.9%) and herbal therapy (16.6%). The study showed that most patients use TM without any motivating factor (62.3%) but some had motivating reasons such as religious practices (14.2%) and to deal with ART side effects (14.5%).
Conclusions: The use of TM among HIV/AIDS patients on antiretroviral therapy (ART) was unusual. Spiritual and herbal therapies were the most commonly employed TMs among the participants in the study. Although a small percentage of patients reported deteriorated disease condition as a result of using TM with ART, a handful of users reported improvement after treatment.
Review on a Novel Advancement in Dry Powder Inhaler
Authors: Bhagat Pooja D. , Redasani Vivek kumar , D. Jadhav Prakash , Velha Atish B. , Mahadik Rutuja A. 
Published: November 2023

Human health management has always been the focus area of medical practitioners across the world. Health is maintained with the right kind of food intake, regular exercise, and remedial medications whenever and wherever necessary. Medications have been an integral part of human health management and improvement ever since. Along with medications, the right kind of drug delivery mechanism plays a crucial role in the efficacy of the medications. Dry powder inhalers (DPI) are one of the most efficient and advanced targeted drug delivery mechanisms. Currently, a wide range of inhaler devices are available on the market for pulmonary drug delivery with a view to maximising drug delivery with low variability compared to other drug delivery systems. Compared to other oral, topical, and parenteral drug delivery methods, DPI's efficiency is manifold. It has varied benefits, like rapid drug absorption due to the high density of blood vessels and the large surface area of the lungs (high lung deposition); the lungs have low enzymatic activity, so this route has a minimum risk for enzymatic degradation. Faster absorption, maximum efficiency, site target, minimum wastage, user-friendly, etc. Historically, DPIs were used only for respiratory-related ailments. But now, due to their better utility value, DPIs are also used in other maladies treatments.
This research paper focuses on various advancements in the field of dry powder inhalers (DPIs), their advanced manufacturing techniques, challenges, and the evolution of technology that help maintain their versatility, stability, and reliability.