bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Crustal Architecture and Along‐Strike Variation in the Mid‐Northern South China Sea Rifted Margin
Authors: Hao Shihao , Mei Lianfu , Ranero César R. , Zhou Zhichao , Pang Xiong , Zheng Jinyun 
Published: January 2024

AbstractRifted margins often show apparent along‐strike variations at the continent‐ocean transition (COT) region, typically occurring gradually over hundreds‐to‐thousands of km between the “magma‐rich” and “magma‐poor” endmembers. In contrast, comparatively smaller‐scale lateral variabilities of rifting structure and faulting style in hyper‐thinned continental crust are not yet well described. The South China Sea (SCS) was recently defined as the archetype of a new “intermediate‐type” margin with neither excess magmatism nor mantle exhumation. However, along‐strike crustal variations along this new type of margin are still little explored. Based on previously unpublished 2D grid of seismic reflection lines and overlapping 3D seismic volumes, we have investigated the crustal structure, faulting style, and the lower crustal reflectivity along ∼400 km of the mid‐northern SCS margin. Our new maps of crystalline‐crust thickness and top basement show that the SCS extension developed in two segments with contrasting tectonic styles separated by a narrow boundary. The eastern domain, resembling a wide‐rift model, displays low‐angle detachment faults and high‐velocity lower crust mainly associated with syn‐rift magmatism indicating weak crustal rheology. The neighboring western domain, resembling a narrow rift model, displays steep crustal‐scale faults indicating comparatively strong rheology. The change from wide to narrow rift—or weak to strong rheology—occurs abruptly, which appears at odds with the current conventional wisdom of mostly gradual transitions over a long distance between rift models. We speculate that the inherited heterogeneity in mantle composition and 3D melt focusing effect may drive this abrupt along‐strike variability in the mid‐northern SCS.
Wind Erodibility and Particulate Matter Emissions of Salt‐Affected Soils: The Case of Dry Soils in a Low Humidity Atmosphere
Authors: Khatei Ganesh , Rinaldo Tobia , Van Pelt R. Scott , D’Odorico Paolo , Ravi Sujith 
Published: January 2024

AbstractArid and semiarid ecosystems around the world are often prone to both soil salinization and accelerated soil erosion by wind. Soil salinization, the accumulation of salts in the shallow portions of the soil profile, is known for its ability to decreases soil fertility and inhibit plant growth. However, the effect of salts on soil erodibility by wind and the associated dust emissions in the early stages of soil salinization (low salinity conditions) remains poorly understood. Here we use wind tunnel tests to detect the effects of soil salinity on the threshold velocity for wind erosion and dust production in dry soils with different textures treated with salt‐enriched water at different concentrations. We find that the threshold velocity for wind erosion increases with soil salinity. We explain this finding as the result of salt‐induced (physical) aggregation and soil crust formation, and the increasing strength of surface soil crust with increasing soil salinity, depending on soil texture. Even though saline soils showed resistance to wind erosion in the absence of abraders, the salt crusts were readily ruptured by saltating sand grains resulting in comparable or sometimes even higher particulate matter emissions compared to non‐saline soils. Interestingly, the salinity of the emitted dust is found to be significantly higher (5–10 times more) than that of the parent soil, suggesting that soil salts are preferentially emitted, and airborne dust is enriched of salts.
Artificial Intelligence and Objective‐Function Methods Can Identify Bankfull River Channel Extents
Authors: Garber Jonathan , Thompson Karen , Burns Matthew J. , Kunapo Joshphar , Zhang Geordie Z. , Russell Kathryn 
Published: January 2024

AbstractBankfull channel extents are of fundamental importance in fluvial geomorphology, to describe the geomorphic character of a river, and to provide a boundary for further processing of morphologic and hydraulic attributes. With ever‐increasing availability of high‐resolution spatial data (e.g., lidar, aerial photography), manual delineation of channel extents is a bottleneck which limits the geomorphic insights that can be gained from that data. To address this limitation, we developed and tested two automated channel delineation methods that define bankfull according to different conceptualisations of bankfull extent: (a) a cross‐sectional method called HydXS that identifies the elevation which maximizes hydraulic depth (cross‐section area/wetted width); and (b) a neural network image segmentation model based on a pretrained model (ResNet‐18), retrained with images derived from a digital elevation model. The cross‐sectional method outperformed the neural network method overall. Its prediction accuracy varied according to channel size and type, with overall precision of 0.87 and recall of 0.80. The neural network method was strongest in larger streams, and outperformed the cross‐sectional method in channel sections with inset benches. A tool to delineate morphological bankfull conditions can allow us to more efficiently implement high‐resolution and large‐scale analyses of channel morphology (e.g., regional hydraulic geometry, channel evolution, physical complexity/habitat surveys), and improve management of fluvial geomorphology and stressors.
A passive wireless surface acoustic wave (SAW) sensor system for detecting warfare agents based on fluoroalcohol polysiloxane film
Authors: Pan Yong , Yan Cancan , Gao Xu , Yang Junchao , Guo Tengxiao , Zhang Lin , Wang Wen 
Published: January 2024

AbstractLong-term monitoring of environmental warfare agengts is a challenge for chemical gas sensors. To address this issue, we developed a 433 MHz passive wireless surface acoustic wave (WSAW) gas sensor for dimethyl methylphosphonate (DMMP) detection. This WSAW gas sensor includes a YZ lithium niobate (LiNbO3) substrate with metallic interdigital transducers (IDTs) etched on it, and an antenna was placed near the IDT. A DMMP-sensitive viscoelastic polymer fluoroalcoholpolysiloxane (SXFA) film was prepared on a LiNbO3 substrate, and mode modeling coupling was used to optimize the design parameters. The sensor can function properly in an environments between −30 °C and 100 °C with humidity less than 60% RH. When the wireless transmission distance was within the range of 0–90 cm, the sensor noise increased with distance, and the stability was less than 32°/h. While optimizing the film thickness of SXFA, a relationship was observed between sensor sensitivity and film thickness. When the film thickness of SXFA reached 450 nm, the optimal value was reached. At a distance of 20 cm between the transmitting and receiving antennas, DMMP was detected at different concentrations with the developed WSAW gas sensor. The lower detection limit of DMMP was 0.48 mg/m3, the sensitivity of the sensor was 4.63°/(mg/m3), and repeatable performance of the sensor was confirmed.
Infant growth and body composition from birth to 24 months: are infants developing the same?
Authors: Norris Shane A. , Nyati Lukhanyo H. , Murphy-Alford Alexia , Lucas Nishani , Santos Ina S. , Costa Caroline S. , Kuriyan Rebecca , Wickranasinghe V. Pujitha , Ariff Shabina , Jayasinghe Sisitha , Kurpad Anura V. , Ismail Leila Cheikh , Hills Andrew P. ,   Multi-center Infant Body Composition Reference Study (MIBCRS), Norris Shane , Murphy-Alford Alexia J. , Ismail Leila C. , Ahmad Tanvir , Ahuja Kiran D. K. , Beckett Jeff M. , Bielemann Renata M. , Byrne Nuala M. , Charania Laila , Christian Michele P. , Divya Priscilla J. , Hanley Anne , Herath Manoja P. , Lanerolle Pulani , Loechl Cornelia , Moktar Najat , Senerath Upul , Slater Christine , Soofi Sajid , Street Steven J. , Valle Neiva C. J. , Yameen Ayesha 
Published: January 2024

Abstract
Background
Given the importance of infancy for establishing growth trajectories, with later-life health consequences, we investigated longitudinal body composition among infants from six economically and ethnically diverse countries.

Methods
We recruited mother-infant dyads using the WHO Multicenter Growth Reference Study criteria. We measured fat-free mass (FFM) in 1393 (49% female) infants from birth to 6 months of age (Australia, India, and South Africa; n = 468), 3–24 months of age (Brazil, Pakistan, South Africa, and Sri Lanka; n = 925), and derived fat mass (FM), fat mass index (FMI), and fat-free mass index (FFMI). Height-for-age (HAZ), weight-for-age (WAZ), and weight-for-length (WHZ) Z-scores were computed. Sex differences were assessed using a t-test, and country differences using a one-way analysis of covariance. We further compared subsamples of children with average (−0.25 > HAZ < +0.25), below-average (≤−0.25) and above-average (≥+0.25) HAZ.

Results
HAZ performed well between 0 and 6 months, but less so between 3 and 24 months. The stunting prevalence peaked at 10.3% for boys and 7.8% for girls, at 24 months. By 24 months, girls had greater FMI (10%) than boys. There were significant differences in FFM (both sexes in all countries) and FM (Brazilian boys, Pakistani and South African girls) by 24 months of age between infants with average, above-average, and below-average HAZ.

Conclusion
In a multi-country sample representing more ideal maternal conditions, body composition was heterogeneous even among infants who exhibited ideal length. Having a mean HAZ close to the median of the WHO standard for length reduced FFM between-country heterogeneity but not FM, suggesting that other factors may influence adiposity.
Awake ripples enhance emotional memory encoding in the human brain
Authors: Zhang Haoxin , Skelin Ivan , Ma Shiting , Paff Michelle , Mnatsakanyan Lilit , Yassa Michael A. , Knight Robert T. , Lin Jack J. 
Published: January 2024

AbstractEnhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task increased awake ripples after encoding of emotional, compared to neutrally-valenced stimuli. Further, post-encoding ripple-locked stimulus similarity is predictive of later memory discrimination. Ripple-locked stimulus similarity appears earlier in the amygdala than in hippocampus and mutual information analysis confirms amygdala influence on hippocampal activity. Finally, the joint ripple-locked stimulus similarity in the amygdala and hippocampus is predictive of correct memory discrimination. These findings provide electrophysiological evidence that post-encoding ripples enhance memory for emotional events.
Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis
Authors: Ma Feiyang , Tsou Pei-Suen , Gharaee-Kermani Mehrnaz , Plazyo Olesya , Xing Xianying , Kirma Joseph , Wasikowski Rachael , Hile Grace A. , Harms Paul W. , Jiang Yanyun , Xing Enze , Nakamura Mio , Ochocki Danielle , Brodie William D. , Pillai Shiv , Maverakis Emanual , Pellegrini Matteo , Modlin Robert L. , Varga John , Tsoi Lam C. , Lafyatis Robert , Kahlenberg J. Michelle , Billi Allison C. , Khanna Dinesh , Gudjonsson Johann E. 
Published: January 2024

AbstractSystemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis of skin and other internal organs. However, the main cellular participants in SSc skin fibrosis remain incompletely understood. Here using differentiation trajectories at a single cell level, we demonstrate a dual source of extracellular matrix deposition in SSc skin from both myofibroblasts and endothelial-to-mesenchymal-transitioning cells (EndoMT). We further define a central role of Hippo pathway effectors in differentiation and homeostasis of myofibroblast and EndoMT, respectively, and show that myofibroblasts and EndoMTs function as central communication hubs that drive key pro-fibrotic signaling pathways in SSc. Together, our data help characterize myofibroblast differentiation and EndoMT phenotypes in SSc skin, and hint that modulation of the Hippo pathway may contribute in reversing the pro-fibrotic phenotypes in myofibroblasts and EndoMTs.
Challenges and opportunities in the diagnosis and treatment of early-onset psychosis: a case series from the youth affective disorders clinic in Stockholm, Sweden
Authors: Lundberg Mathias , Andersson Peter , Lundberg Johan , Desai Boström Adrian E. 
Published: January 2024

AbstractEarly-onset psychosis is linked to adverse long-term outcomes, recurrent disease course, and prolonged periods of untreated illness; thus highlighting the urgency of improving early identification and intervention. This paper discusses three cases where initial emphasis on psychosocial treatments led to diagnostic and therapeutic delays: (1) a 15-year-old misdiagnosed with emotionally unstable personality disorder and autism, who improved on bipolar medication and antipsychotics; (2) another 15-year-old misdiagnosed with autism, who stabilized on lithium and antipsychotics, subsequently allowing for gender dysphoria evaluation; (3) a 9-year-old autistic boy incorrectly treated for ADHD, who recovered with appropriate antipsychotic treatment. These cases illuminate the vital importance of adhering to a diagnostic hierarchy, prioritizing diagnostic utility, and conducting longitudinal evaluations to facilitate early targeted treatment of psychotic symptoms in early-onset psychosis. Adherence to such strategies can minimize delays in managing early-onset psychosis and improve long-term prognoses.
A new antibiotic traps lipopolysaccharide in its intermembrane transporter
Authors: Pahil Karanbir S. , Gilman Morgan S. A. , Baidin Vadim , Clairfeuille Thomas , Mattei Patrizio , Bieniossek Christoph , Dey Fabian , Muri Dieter , Baettig Remo , Lobritz Michael , Bradley Kenneth , Kruse Andrew C. , Kahne Daniel 
Published: January 2024

AbstractGram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic membrane is surrounded by an outer membrane that blocks the entry of most antibiotics. The impenetrable nature of the outer membrane is due to the presence of a large, amphipathic glycolipid called lipopolysaccharide (LPS) in its outer leaflet1. Assembly of the outer membrane requires transport of LPS across a protein bridge that spans from the cytoplasmic membrane to the cell surface. Maintaining outer membrane integrity is essential for bacterial cell viability, and its disruption can increase susceptibility to other antibiotics2–6. Thus, inhibitors of the seven lipopolysaccharide transport (Lpt) proteins that form this transenvelope transporter have long been sought7–9. A new class of antibiotics that targets the LPS transport machine in Acinetobacter was recently identified. Here, using structural, biochemical and genetic approaches, we show that these antibiotics trap a substrate-bound conformation of the LPS transporter that stalls this machine. The inhibitors accomplish this by recognizing a composite binding site made up of both the Lpt transporter and its LPS substrate. Collectively, our findings identify an unusual mechanism of lipid transport inhibition, reveal a druggable conformation of the Lpt transporter and provide the foundation for extending this class of antibiotics to other Gram-negative pathogens.
Dataset for Automatic Region-based Coronary Artery Disease Diagnostics Using X-Ray Angiography Images
Authors: Popov Maxim , Amanturdieva Akmaral , Zhaksylyk Nuren , Alkanov Alsabir , Saniyazbekov Adilbek , Aimyshev Temirgali , Ismailov Eldar , Bulegenov Ablay , Kuzhukeyev Arystan , Kulanbayeva Aizhan , Kalzhanov Almat , Temenov Nurzhan , Kolesnikov Alexey , Sakhov Orazbek , Fazli Siamac 
Published: January 2024

AbstractX-ray coronary angiography is the most common tool for the diagnosis and treatment of coronary artery disease. It involves the injection of contrast agents into coronary vessels using a catheter to highlight the coronary vessel structure. Typically, multiple 2D X-ray projections are recorded from different angles to improve visualization. Recent advances in the development of deep-learning-based tools promise significant improvement in diagnosing and treating coronary artery disease. However, the limited public availability of annotated X-ray coronary angiography image datasets presents a challenge for objective assessment and comparison of existing tools and the development of novel methods. To address this challenge, we introduce a novel ARCADE dataset with 2 objectives: coronary vessel classification and stenosis detection. Each objective contains 1500 expert-labeled X-ray coronary angiography images representing: i) coronary artery segments; and ii) the locations of stenotic plaques. These datasets will serve as a benchmark for developing new methods and assessing existing approaches for the automated diagnosis and risk assessment of coronary artery disease.
Dataset of United States Incident Management Situation Reports from 2007 to 2021
Authors: Nguyen Dung , Belval Erin J. , Wei Yu , Short Karen C. , Calkin David E. 
Published: January 2024

AbstractThis paper presents a unique 15-year dataset of Incident Management Situation Reports (IMSR), which document daily wildland fire situations across ten geographical regions in the United States. The IMSR dataset includes summaries for each reported day on national and regional wildfire activities, wildfire-specific activities, and committed fire suppression resources (i.e., personnel and equipment). This dataset is distinct from other wildfire data sources as it provides daily information on national fire suppression resource utilization, national and regional preparedness levels, and management priority for each region and fire. We developed an open-source Java program, IMSR-Tool, to process 3,124 IMSR reports available from 2007 to 2021 to generate this structured IMSR dataset, which can be updated when future reports become available. The dataset presented here and its future extension enable researchers and practitioners to study historical wildfire activity and resource use across regions and time, examine fire management perceptions, evaluate strategies for fire prioritization and fire resource allocation, and exploit other broader usage to improve wildfire management and response in the United States.
Sperm DNA fragmentation index affect pregnancy outcomes and offspring safety in assisted reproductive technology
Authors: Li Fei , Duan Xiaoyan , Li Mingming , Ma Xing 
Published: January 2024

AbstractThe role of sperm DNA fragmentation index (DFI) in investigating fertility, embryonic development, and pregnancy is of academic interest. However, there is ongoing controversy regarding the impact of DFI on pregnancy outcomes and the safety of offspring in the context of Assisted Reproductive Technology (ART). In this study, we conducted an analysis of clinical data obtained from 6330 patients who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) at the reproductive medical center of The First People's Hospital of Shangqiu and The Affiliated Hospital of Zhengzhou University. The patients was stratified into two distinct groups: IVF group and ICSI group, Within each group, patients were further classified into three subgroups. IVF: group A (< 15%) included 3123 patients, group B (15–30%) included 561 patients, and group C (≥ 30%) included 46 patients. ICSI: group A (< 15%) included 1967 patients, group B (15–30%) included 462 patients, and group C (≥ 30%) included 171 patients. Data were collected and subjected to statistical analysis. There were no significant differences in the basic characteristics among the three groups, and the sperm DFI did not significantly affect the fertilization rates, pregnancy rates, stillbirth rates and the number of birth defects. However, the incidences of miscarriage rates in IVF/ICSI groups with DFI > 30% and DFI 15–30% were significantly higher than those in IVF/ICSI groups with DFI < 15%, and the miscarriage rates in ICSI group with DFI > 30% were significantly higher than DFI 15–30% group, the smooth fitting curve shows that there is a positive correlation between miscarriage rates and sperm DFI (OR 1.095; 95% CI 1.068–1.123; P < 0.001). The birth weight of infants in the IVF/ICSI groups with DFI > 30% and DFI 15–30% exhibited a statistically significant decrease compared to those in the IVF/ICSI groups with DFI < 15%. Furthermore, the birth weight of infants in the ICSI group with DFI > 30% was lower than that of the DFI 15–30% group. The smooth fitting curve analysis demonstrates a negative association between birth weight and sperm DFI (OR 0.913; 95% CI 0.890–0.937; P < 0.001). Sperm DFI has an impact on both miscarriage rates and birth weight in assisted reproductive technology. The smooth fitting curve analysis reveals a positive correlation between miscarriage rates and DFI, while a negative correlation is observed between birth weight and DFI.
Class II HLA-DRB4 is a predictive biomarker for survival following immunotherapy in metastatic non-small cell lung cancer
Authors: Jiang Cindy Y. , Zhao Lili , Green Michael D. , Ravishankar Shashidhar , Towlerton Andrea M. H. , Scott Anthony J. , Raghavan Malini , Cusick Matthew F. , Warren Edus H. , Ramnath Nithya 
Published: January 2024

AbstractImmune checkpoint inhibitors (ICI) are important treatment options for metastatic non-small cell lung cancer (mNSCLC). However, not all patients benefit from ICIs and can experience immune-related adverse events (irAEs). Limited understanding exists for germline determinants of ICI efficacy and toxicity, but Human Leukocyte Antigen (HLA) genes have emerged as a potential predictive biomarker. We performed HLA typing on 85 patients with mNSCLC, on ICI therapy and analyzed the impact of HLA Class II genotype on progression free survival (PFS), overall survival (OS), and irAEs. Most patients received pembrolizumab (83.5%). HLA-DRB4 genotype was seen in 34/85 (40%) and its presence correlated with improved OS in both univariate (p = 0.022; 26.3 months vs 10.2 months) and multivariate analysis (p = 0.011, HR 0.49, 95% CI [0.29, 0.85]). PFS did not reach significance (univariate, p = 0.12, 8.2 months vs 5.1 months). Eleven patients developed endocrine irAEs. HLA-DRB4 was the predominant genotype among these patients (9/11, 81.8%). Cumulative incidence of endocrine irAEs was higher in patients with HLA-DRB4 (p = 0.0139). Our study is the first to suggest that patients with metastatic NSCLC patients on ICI therapy with HLA-DRB4 genotype experience improved survival outcomes. Patients with HLA-DRB4 had the longest median OS (26.3 months). Additionally, we found a correlation between HLA-DRB4 and the occurrence of endocrine irAEs.