bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limited time perspective decreases terminal materialism
Authors: Wu Xuyao , Yang Liu , Lu Mengxi , Li Jing 
Published: February 2025

AbstractTerminal materialism is considered a bad form of materialism and harmful to individuals' well‐being. However, few studies focus on how to reduce this value. The current research examined a way to decrease terminal materialism through a future time perspective. Study 1, through a survey of adults with a wide age, showed that limited time perspective was a significant predictor of terminal materialism. That is, the more limited the perception of time, the lower the level of terminal materialism. In Study 2, participants who were experimentally induced to a limited time perspective became less terminal materialistic, further revealed the causal relationship between future time perspective and terminal materialism. In Study 3, we used qualitative retrospective interviews with cancer survivors to explore the dynamic co‐variation process of future time perception and terminal materialism. The results showed that, consistent with Studies 1 and 2, participants' terminal materialism decreased after experiencing limited future time perception. Our findings indicate that a limited time perspective may be a way for mitigating terminal materialism.
Sufficiency and healthcare emissions
Authors: Parker Joshua 
Published: February 2025

AbstractIn this paper, I am concerned with how healthcare systems ought to transition away from the greenhouse gas emissions that they have historically relied on to provide care. I address two questions in relation to this issue. The first is what emissions target should healthcare systems adopt? Second, is how should the burdens of mitigation be shared fairly in light of that target? I argue that sufficientarianism offers an attractive way to answer both of these questions because it is better situated to strike the right balance between healthcare benefits and the costs of mitigation than rivals. Sufficiency describes the view that what is important from the perspective of distributive justice is that individuals have enough. I argue that this ideal can be used to set a threshold of enough health from which an emissions threshold can be set. Once an emissions threshold is in place, this can be used to demarcate permissible from impermissible emissions in healthcare. In turn, the emissions threshold provides guidance on which emissions are liable to mitigation and when it would be fair for healthcare to shoulder the associated burdens. Permissible emissions, on the other hand, are necessary to secure sufficiency and so healthcare's mitigation responsibilities should be altered in light of this. I also discuss various alternative methods of setting an emissions target like net zero, zero emissions, emissions grandfathering and emissions egalitarianism. I point to several issues with these approaches.
AXL‐Mediated Drug Resistance in ALK‐Rearranged NSCLC Enhanced by GAS6 From Macrophages and MMP11 Positive Fibroblasts
Authors: Utsumi Takahiro , Mizuta Hayato , Seto Yosuke , Uchibori Ken , Nishio Makoto , Okamoto Isamu , Katayama Ryohei 
Published: February 2025

ABSTRACTAnaplastic lymphoma kinase (ALK) rearranged non‐small cell lung cancer (NSCLC) shows marked tumor shrinkage by ALK‐tyrosine kinase inhibitors (TKIs). However, tumors almost inevitably relapse owing to the development of acquired resistance. Resistance mechanisms include secondary ALK mutations and the activation of bypass pathways, such as cMET, cKIT, or EGFR, though some remain unknown. In this study, we analyzed alectinib‐resistant patient samples and identified a significant increase in AXL expression in the tumor, and a high level of GAS6, the ligand for AXL, in the pleural effusion. AXL‐overexpressing H3122 ALK‐rearranged NSCLC cells exhibited partial resistance to alectinib, which was enhanced by GAS6 supplementation but could be overcome by the ALK/AXL inhibitor gilteritinib. Moreover, GAS6‐overexpressing NIH3T3 cells and AXL‐expressing H3122 cells were subcutaneously injected into the left and right sides of nude mice simultaneously, followed by alectinib treatment. The supply of GAS6 from NIH3T3 may have accelerated tumor relapse under alectinib treatment. However, even without GAS6‐overexpressing NIH3T3, AXL‐overexpressing H3122 tumor relapsed within 1 month possibly due to increased host mouse Gas6 expression. Single‐cell RNA sequencing revealed that specific cancer‐associated fibroblasts (CAFs) and a subset of tumor‐associated macrophages (TAMs) are the primary sources of Gas6 in the tumor microenvironment (TME). During alectinib treatment, TAMs increased their infiltration into the TME, whereas CAFs altered their expression patterns, substantially upregulating Mmp11. These findings suggest that AXL expression in resistant cancer cells, combined with increased Gas6 production in the TME, contributes to enhanced ALK‐TKI resistance.
Two Novel Protein‐Truncating Variants in NLRP2 and Their Functional Impacts on the Subcortical Maternal Complex
Authors: Yalcin Zeynep , Gao Zheng , Abdelrazek Ibrahim M. , Bareke Eric , Majewski Jacek , Abdalla Ebtesam , Tan Seang‐Lin , Li Lei , Slim Rima 
Published: February 2025

ABSTRACTFemale infertility is a prevalent reproductive disorder with high genetic heterogeneity. Previous reports have demonstrated the causal role of biallelic pathogenic variants in the Subcortical Maternal Complex (SCMC) genes in female reproductive failure with some leading to infertility, early embryonic loss, and molar pregnancies, while others are compatible with live birth with and without multilocus imprinting disorders (MLID). Here, we report two deleterious protein‐truncating variants, c.1326delG, p.Leu443Phefs*78 and c.2802_2803del, p.Arg935Metfs*15, in heterozygous state in the NLRP2 gene of a patient with primary infertility, four early miscarriages, and one failed attempt of intracytoplasmic sperm injection. We show that the two variants mediate mRNA decay in EBV‐transformed lymphoblastoid cells from the patient, lead to decreased NLRP2 protein levels, and alter NLRP2 interactions with other members of the SCMC in vitro. This study emphasizes the importance of performing clinical exomes for patients with recurrent reproductive failure and reporting their variants and reproductive histories to improve patient counseling.
Long‐term bowel function following delayed coloanal anastomosis: Analysis of a multicentric cohort study (GRECCAR)
Authors: Collard Maxime K. , Tuech Jean‐Jacques , Sabbagh Charles , Souadka Amine , Loriau Jérome , Rullier Eric , Marchal Frédéric , Germain Adeline , Benoist Stéphane , Faucheron Jean‐Luc , Manceau Gilles , Dubois Anne , Laforest Anaïs , Sourrouille Isabelle , Protat Aurore , Mège Diane , Lakkis Zaher , Prudhomme Michel , Derieux Simon , Ouaissi Mehdi , Venara Aurélien , Brigand Cécile , Lelong Bernard , Pautrat Karine , Maggiori Leon , Lebreton Gil , Rouanet Philippe , Pocard Marc , Duchalais Emilie , Denost Quentin , Parc Yann , Lefevre Jérémie H. ,   for the GRECCAR Group
Published: February 2025

AbstractAimAlteration of bowel function after delayed coloanal anastomosis (DCAA) might be a limitation to its utilization. Our aim was to assess the long‐term bowel function of DCAA in a large multicentric cohort.MethodAll patients who underwent DCAA interventions at 29 GRECCAR‐affiliated hospitals between 2010 and 2021 were retrospectively included. Low anterior resection syndrome (LARS) score or confection of a stoma due to poor bowel function was assessed in eligible patients. Good bowel function was defined by the preservation of bowel continuity with no LARS or a minor LARS.ResultsAmong the 385 eligible patients to assess long‐term bowel continuity, 63% (n = 243) responded to the questionnaire or had a definitive stoma because of poor bowel function. After a median follow‐up of 32 months, good bowel function was reported by 60% (n = 146) of patients (with no LARS 36% and minor LARS 24%), whereas 40% of patients (n = 146) had a poor bowel function including major LARS (36%) and definitive stoma due to poor bowel function (4%). No variables tested were predictive of a poor bowel function after DCAA, including a history of pelvic radiotherapy (P = 0.722), salvage DCAA after failure of a previous anastomosis (P = 0.755), presence of a diverting stoma (P = 0.556), occurrence of an anastomotic leakage (P = 0.416) and time interval from the DCAA to the bowel function assessment (P = 0.350).ConclusionsNo LARS or minor LARS was reached for 60% of patients after DCAA. Less than 5% of patients received a definitive stoma due to a poor bowel function.
Effect of iGlarLixi on continuous glucose monitoring—measured time in range in insulin‐naive adults with suboptimally controlled type 2 diabetes
Authors: Frías Juan P. , Ratzki‐Leewing Alexandria , Dex Terry , Meneghini Luigi , Rodrigues Amélie , Shah Viral N. 
Published: February 2025

AbstractAimsPeople with type 2 diabetes (T2D) and glycated haemoglobin (HbA1c) ≥9% may benefit from fixed‐ratio combination therapies such as iGlarLixi (insulin glargine 100 U/mL and lixisenatide 33 μg/mL). Use of continuous glucose monitoring (CGM) is recommended, but data are lacking to assess the impact of iGlarLixi in individuals with HbA1c ≥9%.Materials and MethodsSoli‐CGM (NCT05114590) was a 16‐week, multicentre, open‐label study evaluating the efficacy of once‐daily iGlarLixi using blinded CGM‐based metrics in insulin‐naive adults with HbA1c ≥9%–13% who were receiving ≥2 oral antihyperglycaemic agents (OADs) ± glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs). The primary outcome was the change from baseline to week 16 in percent time in range (TIR; 70–180 mg/dL). Secondary outcomes included change in mean daily blood glucose (BG), maximum postprandial glucose 4 h post‐breakfast (PPG‐4 h), and time above range (TAR; >180 mg/dL). On‐treatment hypoglycaemia was assessed.ResultsThe study enrolled 124 participants (mean age, 55.6 years; HbA1c, 10.2%). Sixteen weeks of treatment with iGlarLixi improved TIR (+26.2%), mean BG (−52.5 mg/dL), maximum PPG‐4 h (−73.7 mg/dL), and TAR (−28.7%); all p < 0.001. Rates of American Diabetes Association level 1 (BG <70 but ≥54 mg/dL) and level 2 (BG <54 mg/dL) hypoglycaemia were reported as 1.4 and 0.6 events per person‐year, respectively. No level 3 events (requiring assistance) were reported.ConclusionsIn people with T2D suboptimally controlled on ≥2 OADs ± GLP‐1 RAs, 16 weeks of treatment with iGlarLixi significantly improved TIR and reduced TAR without severe hypoglycaemia.
Survey among adult users of semaglutide for weight loss in Denmark: User characteristics, treatment expectations and experienced effects
Authors: Sørensen Malene Svoldgaard , Pottegård Anton , Andersen Nanna Elman , Thomsen Reimar W. , Lundby Carina 
Published: February 2025

AbstractAimsSince the launch of semaglutide for weight loss (Wegovy®, SEMA‐WL) in late 2022, there has been a huge increase in new users of SEMA‐WL. We explored characteristics, treatment expectations and experienced effectiveness and side effects among Danish adults using SEMA‐WL.Materials and MethodsA questionnaire‐based survey was conducted from September to December 2023 across 29 Danish community pharmacies. During a 10‐day period, pharmacies invited consecutive individuals aged ≥18 years redeeming a prescription on SEMA‐WL to complete an electronic questionnaire.ResultsA total of 1013 individuals were invited to study participation of which 55% (n = 559) accepted. Users of SEMA‐WL were primarily female (78%, n = 434) and middle‐aged adults (36–65 years; 76%, n = 423), with a median body mass index of 36 (interquartile range [IQR] 32–40) at treatment initiation. Two in three users had personally asked their general practitioner to initiate treatment (70%, n = 393). Four in ten users had not discussed expected treatment duration with their general practitioner (42%, n = 237), almost half (46%, n = 258) expected treatment for a limited time period, while only 11% (n = 64) expected lifelong treatment. Self‐reported median weight loss was 5.3% (IQR 3.2–8.5) for users treated for <3 months, 10% (IQR 8.2–14) for 3–5 months of treatment and 17% (IQR 13–21) for those treated for >5 months. More than half of users (59%, n = 330) had experienced side effects, most commonly nausea (35%, n = 193) and constipation (29%, n = 160).ConclusionsThis study provides valuable insights into the characteristics, treatment expectations and effects experienced by Danish adult users of SEMA‐WL.
A Taxonomy of Neuroscientific Strategies Based on Interaction Orders
Authors: Neri Matteo , Brovelli Andrea , Castro Samy , Fraisopi Fausto , Gatica Marilyn , Herzog Ruben , Mediano Pedro A. M. , Mindlin Ivan , Petri Giovanni , Bor Daniel , Rosas Fernando E. , Tramacere Antonella , Estarellas Mar 
Published: February 2025

ABSTRACTIn recent decades, neuroscience has advanced with increasingly sophisticated strategies for recording and analysing brain activity, enabling detailed investigations into the roles of functional units, such as individual neurons, brain regions and their interactions. Recently, new strategies for the investigation of cognitive functions regard the study of higher order interactions—that is, the interactions involving more than two brain regions or neurons. Although methods focusing on individual units and their interactions at various levels offer valuable and often complementary insights, each approach comes with its own set of limitations. In this context, a conceptual map to categorize and locate diverse strategies could be crucial to orient researchers and guide future research directions. To this end, we define the spectrum of orders of interaction, namely, a framework that categorizes the interactions among neurons or brain regions based on the number of elements involved in these interactions. We use a simulation of a toy model and a few case studies to demonstrate the utility and the challenges of the exploration of the spectrum. We conclude by proposing future research directions aimed at enhancing our understanding of brain function and cognition through a more nuanced methodological framework.
Network Segregation and Integration Changes in Healthy Aging: Evidence From EEG Subbands During the Visual Short‐Term Memory Binding Task
Authors: Fide Ezgi , Bora Emre , Yener Görsev 
Published: February 2025

ABSTRACTWorking memory, which tends to be the most vulnerable cognitive domain to aging, is thought to depend on a functional brain network for efficient communication. The dynamic communication within this network is represented by segregation and integration. This study aimed to investigate healthy aging by examining age effect on outcomes of graph theory analysis during the visual short‐term memory binding (VSTMB) task. VSTMB tasks rely on the integration of visual features and are less sensitive to semantic and verbal strategies. Effects of age on neuropsychological test scores, along with the EEG graph‐theoretical integration, segregation and global organization metrics in frequencies from delta to gamma band were investigated. Neuropsychological assessment showed low sensitivity as a measure of age‐related changes. EEG results indicated that network architecture changed more effectively during middle age, while this effectiveness appears to vanish or show compensatory mechanisms in the elderly. These differences were further found to be related to cognitive domain scores. This study is the first to demonstrate differences in working memory network architecture across a broad age range.
Multifaceted Biomarkers Suggest a Similar Profile of CNS Pathology in Relapsing and Progressive MS
Authors: Blok Katelijn M. , Klein Kranenbarg Romy A. M. , Ananth Kirtana , Engelenburg Hendrik J. , van den Bosch Aletta , Giannini Lucia A. A. , de Beukelaar Janet , Seelaar Harro , Huitinga Inge , Green Ari , Wokke Beatrijs , Abdelhak Ahmed , Smolders Joost 
Published: February 2025

ABSTRACTBackgroundRelapsing–remitting (RR) and primary progressive (PP) multiple sclerosis (MS) have distinct clinical courses, but underlying pathophysiological differences remain unclear. We compared pathological components between RRMS, PPMS, and other inflammatory and neurodegenerative disorders, leveraging soluble biomarkers and post‐mortem pathology.MethodsSerum and cerebrospinal fluid (CSF) of people diagnosed with (pw) PPMS (n = 104), RRMS (n = 38), Alzheimer's disease (AD, n = 22), neuromyelitis optica spectrum disorder (NMOSD, n = 10), and myelin oligodendrocyte glycoprotein–associated disease (MOGAD, n = 10) were collected. B‐cell maturation antigen (BCMA), soluble CD27 (sCD27), osteopontin (OPN), chitinase‐3‐like‐1 (CHI3L1), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) and synaptosomal‐associated protein‐25 (SNAP25) were measured. Lymphocytes (CD20+, CD138+, CD3+) and pyramidal‐tract axonal density in RR‐onset (n = 86) and PPMS (n = 45) post‐mortem brain tissue were quantified.ResultsSoluble and post‐mortem tissue biomarkers did not differ between pwRRMS and pwPPMS. Compared to AD, MS had higher CSF sCD27 (p < 0.001) but lower serum CHI3L1 and GFAP, and CSF OPN and SNAP25 (all p < 0.05). Serum OPN was lower in RRMS than NMOSD (p = 0.013). Principal component analyses and K‐means clustering showed substantial overlap of RRMS and PPMS biomarkers, distinct from AD. In all pwMS, serum NfL and CSF BCMA correlated with clinical/radiological disease activity, CSF BCMA and sCD27 with inflammatory parameters, and serum GFAP, CSF GFAP, and CSF NfL with Expanded Disability Status Scale (EDSS) score.ConclusionsSerum and CSF soluble biomarker profiles and post‐mortem pathology do not differentiate RRMS from PPMS diagnoses but reflect the extent of inflammation and tissue damage. Detailed assessment of MS‐associated inflammation and tissue damage may enhance classification and therapeutic strategies.
Utilising Explainable AI to Enhance Real‐Time Student Performance Prediction in Educational Serious Games
Authors: Gomez Manuel J. , Armada Sánchez Álvaro , Albaladejo‐González Mariano , García Clemente Félix J. , Ruipérez‐Valiente José A. 
Published: February 2025

ABSTRACTIn recent years, serious games (SGs) have emerged as a powerful tool in education by combining pedagogy and entertainment, facilitating the acquisition of knowledge and skills in engaging environments. SGs enable the collection of valuable interaction data from students, allowing for the analysis of student performance, with artificial intelligence (AI) playing a key role in processing this data to make informed inferences about their knowledge and skills. However, the lack of explainability in AI models represents a significant challenge. This research aims to develop an interpretable model for predicting students' performance in real‐time while playing an SG by: (1) calculating the performance of an interpretable prediction model of task completion in an SG and (2) demonstrating the application of the interpretable model for just‐in‐time (JIT) classroom interventions. Our results show that we are able to predict students' task completion in real‐time with a balanced accuracy result of 77.21% after a short playtime has elapsed. In addition, an explainable artificial intelligence (XAI) approach has been applied to ensure the interpretability of the developed models. This approach supports personalised learning experiences, unlocks AI benefits for non‐technical users, and maintains transparency in education.
Different Approaches to Measuring Diversity Affect the Strength of the Relationship Between Biodiversity and Ecosystem Function in Freshwater Studies: A Meta‐Analysis
Authors: da Silva Samiris Pereira , Carneiro Fernanda Melo , Nabout João Carlos 
Published: February 2025

ABSTRACT

The notion that biodiversity begets greater ecosystem functioning is an enduring paradigm in ecology, supported by a growing body of research demonstrating the significant effects of biodiversity on ecosystem functioning (BEF). These studies use several diversity metrics, which can be estimated through taxonomic, functional and molecular approaches.

Here we aim to investigate the performance of different approaches (taxonomic, functional and molecular), considering the different biodiversity metrics in each approach (e.g., richness, composition, among others). Additionally, we assess the individual response of ecosystem processes (e.g., productivity, decomposition, among others) to biodiversity in each approach. To this end, we perform a review and meta‐analysis of studies that assessed BEF relationship in continental aquatic environments, encompassing 94 studies and 322 effect sizes. Our data set includes diverse contexts, with different organisms, environments and ecosystem processes.

We found an overall positive association between biodiversity and the functioning of continental aquatic ecosystems (Effect size = 0.37). We also found differences in the proportions of biodiversity metrics applied in the studies between the different approaches, as well as some geographic bias, with a predominance of studies conducted in the northern hemisphere. Additionally, lakes were the most commonly studied systems, and productivity functions were frequently analysed. We found that the molecular approach, applied exclusively in microbial studies in our dataset, showed better performance in evaluating the BEF relationship.

Despite the strengths of the molecular approach, it is not without limitations. Some challenges such as high costs of sequencing and maintaining database infrastructure, can hinder its application. In light of these limitations, we understand that applying functional approaches, specifically functional richness and functional evenness metrics, in the study of the BEF relationship in continental aquatic ecosystems is promising. This can be an alternative for the continuity and advancement of studies of the BEF relationship in these environments. We also highlighted the need for studies in the southern hemisphere, covering the different freshwater ecosystem and multiple functions.
Exploring Clover‐Based Nurse Cropping for Birdsfoot Trefoil Establishment and Yield
Authors: Ates Serkan , Seeno Elizabeth , MacAdam Jennifer W. , Moot Derrick J. 
Published: February 2025

ABSTRACTBirdsfoot trefoil (Lotus corniculatus L.), renowned for its persistence in challenging soil and climate conditions, serves as a valuable non‐bloating forage legume in temperate regions. However, its slow establishment and low initial yields in the establishment year make it vulnerable to competition from companion and weeds species. Therefore, we investigated the effects of three legume species (red clover, Trifolium pretence L.; balansa clover, Trifolium michelianum L.; and berseem clover, Trifolium alexandrinum L.) as nurse crops at three seeding rates (target 60, 120 or 240 plant m2). These companions increased (p < 0.01) total forage accumulation by 37%–55% in the establishment year. The number of established birdsfoot trefoil seedlings was similar in monoculture and mixtures with annual legumes but lower (p < 0.01) when planted with red clover. Neither seeding rate nor legume species impeded birdsfoot trefoil growth in the second season. Notably, binary mixtures of birdsfoot trefoil and red clover outperformed (p < 0.01) the birdsfoot trefoil monoculture, yielding an additional 3260–5440 kg DM ha−1. These findings highlight a practical strategy for farmers to sow birdsfoot trefoil with a suitable annual or perennial legume species, increasing total forage production without compromising the subsequent birdsfoot trefoil yield or nutritive value.