bluuebunny/crossref_metadata_2025_split huggingface dataset:
An extensive effect of religiosity on the purchasing decisions of halal products
Authors: Rafiki Ahmad , Hidayat Sutan Emir , Nasution Muhammad Dharma Tuah Putra 
Published: December 2023

PurposeThis study aims to examine the moderator effect of religiosity on the relationship between halal brand awareness and habit towards purchasing decisions of halal products.Design/methodology/approachThe quantitative method is used in this study. Descriptive and statistical (multiple and moderated regression) analyses are employed to test the hypothesis according to the research model. The data is collected using a cross-sectional design from 197 respondents consisting of business owners in North Sumatera, Indonesia.FindingsIt is found that both halal brand awareness and habit have a positive and significant effect on the purchasing decision of halal products. Meanwhile, religiosity significantly acts as a moderating variable in the relationship between awareness and purchasing decisions, as well as habit and purchasing decisions.Research limitations/implicationsThis study revealed the important factor of religiosity as a moderating factor in purchase decisions of halal products. The government may need to collaborate with Islamic educational institutions to raise awareness of the halal concept and product awareness. It is assumed that individuals who know about the Islamic religion will have a higher degree of awareness of halal products compared to individuals with limited knowledge of Islam; thus, providers of Islamic education play a crucial role in raising the level of awareness of halal products. Schools may serve as catalysts for the dissemination of knowledge of halal products.Originality/valueDeveloping halal product markets can be done by enhancing the religiosity level of consumers, one of them through attending formal or informal religious classes.
Circ_0008410 contributes to fibroblast‐like synoviocytes dysfunction by regulating miR‐149‐5p/HIPK2 axis
Authors: Su Wensi , Ye Zhifang , Wang Guangji , Huang Hui , Fang Yehan 
Published: December 2023

AbstractCircular RNAs (circRNAs) play functional roles in rheumatoid arthritis (RA) progression. Fibroblast‐like synoviocytes (RASFs) are the main effectors in RA development. In this study, we explored the function and mechanism of circ_0008410 in RASFs. qRT‐PCR was used to detect the expression of circ_0008410, microRNA‐149‐5p (miR‐149‐5p), and homeodomain‐interacting protein kinase 2 (HIPK2). Cell counting kit‐8, EdU assay, flow cytometry, and transwell assay were performed to evaluate cell proliferation, apoptosis, migration, and invasion. Western blot measured the protein levels of related markers and HIPK2. The levels of IL‐1β, TNF‐α, and IL‐6 were tested by corresponding ELISA kits and Western blot. The combination between miR‐149‐5p and circ_0008410 or HIPK2 was detected by dual‐luciferase reporter assay or RNA immunoprecipitation (RIP) assay. Our data showed that circ_0008410 and HIPK2 were elevated, while miR‐149‐5p was downregulated in RA synovial tissues and RASFs. Circ_0008410 promoted RASF proliferation, migration, invasion, and inflammation while inhibiting apoptosis. MiR‐149‐5p was a target of circ_0008410, and its overexpression could reverse the promoting effects of circ_0008410 on RASF dysfunction. Moreover, miR‐149‐5p could target HIPK2 to suppress RASF proliferation, migration, invasion, and inflammation. Collectively, circ_0008410 promoted RASF dysfunction via miR‐149‐5p/HIPK2, which might provide a potential target for RA therapy.
Are layoffs an industry norm? Exploring how industry‐level job decline or growth impacts firm‐level layoff implementation
Authors: Chhinzer Nita 
Published: December 2023

AbstractCorporate layoffs are a globally prolific organisational activity, but little is known about how industry‐level employment loss or gain impacts firm‐level layoff implementation. Grounded in institutional theory, this study posits that firms in industries experiencing employment decline align with a cost‐containment approach, while firms in industries experiencing employment growth focus on social exchange theory when executing employee layoffs. Analysis of 573 mass layoffs from March 2013 to May 2019 compared downsizing scope (layoff severity and frequency), explanations, alternatives, advance notice, and firm characteristics (unionisation and firm size) in employment gain versus loss industries. The findings indicate that meaningful differences exist. Firms operating in employment loss industries implement layoffs focused on cost‐containment, including less severe layoffs, less extensive but more demand‐decline focused explanations, and use more cost‐reduction layoff alternatives, when compared to layoffs in employment gaining industries. Firms operating in industries experiencing growth execute layoffs in a manner that maintains the social exchange expectations between employee‐employer. In addition, firms in declining industries are more likely to be unionised and larger than firms in growing industries. This research helps reconcile divergent layoff perspectives by considering how variations in external factors impact corporate layoffs.
Quantitative processing of broadband data as implemented in a scientific split‐beam echosounder
Authors: Andersen Lars Nonboe , Chu Dezhang , Handegard Nils Olav , Heimvoll Harald , Korneliussen Rolf , Macaulay Gavin J. , Ona Egil , Patel Ruben , Pedersen Geir 
Published: December 2023

Abstract

The use of quantitative broadband echosounders for biological studies and surveys can offer considerable advantages over narrowband echosounders. These include improved spectral‐based target identification and significantly increased ability to resolve individual targets. An understanding of current processing steps is required to fully utilise and further develop broadband acoustic methods in marine ecology.

We describe the steps involved in processing broadband acoustic data from raw data to frequency dependent target strength () and volume backscattering strength () using data from the EK80 broadband scientific echosounder as examples. Although the overall processing steps are described and build on established methods from the literature, multiple choices need to be made during implementation.

To highlight and discuss some of these choices and facilitate a common understanding within the community, we have also developed a Python code which will be made publicly available and open source. The code follows the steps using raw data from two single pings, showing the step‐by‐step processing from raw data to and .

This code can serve as a reference for developing custom code or implementation in existing processing pipelines, as an educational tool and as a starting point for further development of broadband acoustic methods in fisheries acoustics.
Causal relationship between worry, tension, insomnia, sensitivity to environmental stress and adversity, and erectile dysfunction: a study using Mendelian randomization
Authors: Zhang Hao , Wang Shiqi , Ma Sicheng , Zhang Chenming , Wang Zulong , Yan Peiyu 
Published: December 2023

AbstractBackgroundThis study aims to investigate the causal relationship between erectile dysfunction (ED) and psychological states including worry, tension, insomnia, sensitivity to environmental stress and adversity (SESA).MethodThis study the used two‐sample bi‐directional Mendelian randomization (MR) method. The study data was obtained from a pooled dataset of genome‐wide association studies (GWAS). The bi‐directional MR analysis was performed using inverse variance weighting, weighted median method, and MR‐Egger regression analysis to assess the causality between ED and psychological states including worry, tension, insomnia, SESA in terms of odd ratios (OR). The study tested for heterogeneity using the Cochran Q method and for multiple validity using the MR‐Egger and MR‐PRESSO methods.ResultsIn forward MR analysis correlating worry, tension, insomnia, and SESA as exposures, no causal relationship was found between worry or tension and ED (p < 0.05). However, insomnia (p = 0.001, OR = 3.441, 95%CI = 1.593–7.435) and SESA (p = 0.004, OR = 1.804, 95%CI = 1.203–2.701) were found to have a significant causal effect on ED risk. The reverse MR analysis with ED as the exposure did not show any significant correlation (all p > 0.05).ConclusionIndividuals with insomnia and SESA are at higher risk for developing ED. Clinical evaluation should be more thorough for these individuals. Insomnia can be treated simultaneously with psychological counseling to reduce the risk of ED. In addition, there is no evidence to suggest that worry and tension increase the risk of ED.
Prognostic value of pretreatment indocyanine green angiography in the acute uveitic phase of Vogt‐Koyanagi‐Harada disease
Authors: Tobaigy Mohannad F. , Abouammoh Marwan A. , AlBloushi Abdulrahman F. , Saifaldein Amjad Ameen , Gikandi Priscilla , Almousa Abdullah N. , Herbort Carl P. , El‐Asrar Ahmed Abu 
Published: December 2023

AbstractPurposeTo investigate the prognostic value of pretreatment indocyanine green angiographic (ICGA) features in initial‐onset acute uveitis associated with Vogt‐Koyanagi‐Harada (VKH) disease.MethodsRetrospective analysis of 84 patients (168 eyes). Main outcome measures were final visual acuity, development of ‘sunset glow fundus’ (SGF) and progression to chronic recurrent evolution.ResultsThirty‐eight patients (76 eyes) presented in the phase preceding anterior segment (AS) inflammation (early presentation) and 46 patients (92 eyes) had AS inflammation at presentation (late presentation). The mean number of hypofluorescent dark dots (HDDs) and frequency of disc hyperfluorescence were more in the late presentation group (p < 0.001 for both comparisons), whereas the early presentation group showed higher frequencies of peripapillary punctate choroidal hyperfluorescence (p < 0.001) and hypofluorescent patches involving macula corresponding to the areas of exudative retinal detachment (p = 0.012). The mean number of HDDs and the frequency of disc hyperfluorescence were higher among eyes that developed SGF (p < 0.001 for both comparisons) and eyes that progressed to chronic recurrent evolution (p < 0.001; p = 0.001, respectively). The frequencies of peripapillary punctate choroidal hyperfluorescence and hypofluorescent patches corresponding to the areas of exudative retinal detachment were less in the eyes that developed SGF (p = 0.019; p = 0.003, respectively). Punctate choroidal hyperfluorescence elsewhere was less frequent in the eyes that developed SGF (p < 0.001) and eyes that progressed to chronic recurrent evolution (p = 0.002).ConclusionsPretreatment ICGA has a prognostic value in initial‐onset acute uveitis associated with VKH disease.
Therapeutic benefit of melatonin in 5‐fluorouracil‐induced renal and hepatic injury
Authors: Mansoori Razieh , Kazemi Sohrab , Almasi Darya , Hosseini Seyed Mohammad , Karim Bardia , Nabipour Majid , Moghadamnia Ali Akbar 
Published: December 2023

AbstractNephrotoxicity and hepatotoxicity include increased oxidative stress and apoptosis; as a result, liver and kidney damage are related to its pathogenesis. These are significant side effects caused in cancer patients treated with 5‐FU. In the research, 25 rats were divided into five groups, including control, 5‐FU and 5‐FU + 2.5, 5 and 10 mg/kg melatonin (MEL), and the protective impact of MEL against 5‐FU‐induced hepatorenal damage in rats was investigated. 5‐FU caused significant harm, resulting in severe renal failure and histopathological changes. It also increased BUN, creatinine and hepatic function markers levels while decreasing superoxide dismutase and glutathione peroxidase activity. Additionally, 5‐FU led to a notable increase in malondialdehyde content. However, MEL co‐administration to rats reversed most biochemical and histologic effects. In the control and MEL + 5‐FU groups, the values were comparable. The doses of MEL treatment had a significant positive impact on 5‐FU‐induced oxidative stress, apoptosis, lipid peroxidation and kidney damage. Our data concluded that MEL has an ameliorative effect on hepatorenal damage caused by 5‐FU.
PRESIDENTIAL ADDRESS: Lessons from Africa: Ubuntu, solidarity, dignity, kinship, and humility
Authors: Jecker Nancy S. 
Published: December 2023

AbstractThis paper addresses bioethics in the context of the coronavirus disease 2019 (COVID‐19) pandemic. The Introduction (Section 1) highlights that at the field's inception, infectiousness was not front and center. Instead, infectious disease was widely perceived as having been conquered. This made it possible for bioethicists to center values such as individual autonomy, informed consent, and a statist conception of justice. Section 2 urges shifting to values more fitting for the moment the world is in. To find these, it directs attention to the Global South, and in particular, Africa, and to the values of ubuntu, solidarity, dignity, kinship, and humility. The paper concludes (in Section 3) that 21st‐century challenges facing bioethics are increasingly global, and calls on bioethicists themselves to be more globally inclusive in their approaches.
Spermatozoa in mice lacking the nucleoporin NUP210L show defects in head shape and motility but not in nuclear compaction or histone replacement
Authors: Al Dala Ali Maha , Longepied Guy , Nicolet Aurore , Metzler‐Guillemain Catherine , Mitchell Michael J. 
Published: December 2023

AbstractBiallelic loss‐of‐function mutation of NUP210L, encoding a testis‐specific nucleoporin, has been reported in an infertile man whose spermatozoa show uncondensed heads and histone retention. Mice with a homozygous transgene intronic insertion in Nup210l were infertile but spermatozoa had condensed heads. Expression from this insertion allele is undefined, however, and residual NUP210L production could underlie the milder phenotype. To resolve this issue, we have created Nup210lem1Mjmm, a null allele of Nup210l, in the mouse. Nup210lem1Mjmm homozygotes show uniform mild anomalies of sperm head morphology and decreased motility, but nuclear compaction and histone removal appear unaffected. Thus, our mouse model does not support that NUP210L loss alone blocks spermatid nuclear compaction. Re‐analyzing the patient's exome data, we identified a rare, potentially pathogenic, heterozygous variant in nucleoporin gene NUP153 (p.Pro485Leu), and showed that, in mouse and human, NUP210L and NUP153 colocalize at the caudal nuclear pole in elongating spermatids and spermatozoa. Unexpectedly, in round spermatids, NUP210L and NUP153 localisation differs between mouse (nucleoplasm) and human (nuclear periphery). Our data suggest two explanations for the increased phenotypic severity associated with NUP210L loss in human compared to mouse: a genetic variant in human NUP153 (p.Pro485Leu), and inter‐species divergence in nuclear pore function in round spermatids.
A systematic review and a meta‐analysis on the incidence of obstetric anal sphincter injuries during vaginal delivery
Authors: Orlando Alessandra , Thomas Gregory , Murphy Jamie , Hotouras Alexander , Bassett Paul , Vaizey Carolynne 
Published: December 2023

AbstractAimThe incidence of obstetric anal sphincter injuries (OASIS) has increased in the past two decades despite improved awareness of the risk factors. This study aimed to define the incidence of OASIS in women with different features (instrumental delivery or other variables).MethodsA systematic review was conducted on articles reporting the incidence of OASIS. This review aims to examine the association of instrumentation and OASIS by performing a formal systematic review of the published literature. Databases used for the research were MEDLINE, Embase, CINAHL and ‘Maternity and infant care’ databases.ResultsTwo independent reviewers screened the selected articles. 2326 duplicates were removed from the total of 4907 articles. The remaining 2581 articles were screened for title and abstract. 1913 articles were excluded due to irrelevance. The remaining 300 were screened as full text. Primiparity associated with the use of forceps were the features associated with the highest incidence of OASIS in the selected articles (19.4%). OASIS in all women had an overall incidence of 3.8%. The incidence of OASIS in all women by geographical region was the highest (6.5%) in North America.ConclusionsThere are various factors that impact on the incidence of OASIS and the combination of some of these, such as the use of forceps in primiparas, resulted in the highest incidence of OASIS. The lack of international consensus is limiting the improvements that can be done to reduce OASIS rates and improve best clinical practice.
Updated DPYDHapB3 haplotype structure and implications for pharmacogenomic testing
Authors: Turner Amy J. , Haidar Cyrine E. , Yang Wenjian , Boone Erin C. , Offer Steven M. , Empey Philip E. , Haddad Andrew , Tahir Saba , Scharer Gunter , Broeckel Ulrich , Gaedigk Andrea 
Published: December 2023

AbstractThe DPYD gene encodes dihydropyrimidine dehydrogenase, the rate‐limiting enzyme for the metabolism of fluoropyrimidines 5‐fluorouracil and capecitabine. Genetic variants in DPYD have been associated with altered enzyme activity, therefore accurate detection and interpretation is critical to predict metabolizer status for individualized fluoropyrimidine therapy. The most commonly observed deleterious variation is the causal variant linked to the previously described HapB3 haplotype, c.1129‐5923C>G (rs75017182) in intron 10, which introduces a cryptic splice site. A benign synonymous variant in exon 11, c.1236G>A (rs56038477) is also linked to HapB3 and is commonly used for testing. Previously, these single‐nucleotide polymorphisms (SNPs) have been reported to be in perfect linkage disequilibrium (LD); therefore, c.1236G>A is often utilized as a proxy for the function‐altering intronic variant. Clinical genotyping of DPYD identified a patient who had c.1236G>A, but not c.1129‐5923C>G, suggesting that these two SNPs may not be in perfect LD, as previously assumed. Additional individuals with c.1236G>A, but not c.1129‐5923C>G, were identified in the Children's Mercy Data Warehouse and the All of Us Research Program version 7 cohort substantiating incomplete SNP linkage. Consequently, testing only c.1236G>A can generate false‐positive results in some cases and lead to suboptimal dosing that may negatively impact patient therapy and prospect of survival. Our data show that DPYD genotyping should include the functional variant c.1129‐5923C>G, and not the c.1236G>A proxy, to accurately predict DPD activity.
Pharmacokinetics of dacarbazine and unesbulin and CYP1A2‐mediated drug interactions in patients with leiomyosarcoma
Authors: Gao Lan , Kaushik Diksha , Van Tine Brian A. , Ingham Matthew A. , Attia Steven , Meyer Christian F. , Schwartz Gary K. , Maliakal Pius , Baird John D. , Ma Jiyuan , Barrett Rosemary , D'Silva Dhiren , O'Keefe Kylie , Kong Ronald 
Published: December 2023

AbstractUnesbulin is being investigated in combination with dacarbazine (DTIC) as a potential therapeutic agent in patients with advanced leiomyosarcoma (LMS). This paper reports the pharmacokinetics (PK) of unesbulin, DTIC, and its unreactive surrogate metabolite 5‐aminoimidazole‐4‐carboxamide (AIC) in 29 patients with advanced LMS. Drug interactions between DTIC (and AIC) and unesbulin were evaluated. DTIC (1000 mg/m2) was administered to patients with LMS via 1‐h intravenous (i.v.) infusion on day 1 of every 21‐day (q21d) cycle. Unesbulin dispersible tablets were administered orally twice weekly (b.i.w.), starting on day 2 of every cycle, except for cycle 2 (C2), where unesbulin was dosed either on day 1 together with DTIC or on day 2, 1 day after DTIC administration. The PK of DTIC, AIC, and unesbulin in cycle 1 (C1) and C2 were estimated using noncompartmental analysis. DTIC and AIC were measurable immediately after the start of infusion and reached maximum plasma concentration (Cmax) immediately or shortly after end of infusion at 1.0 and 1.4 h (time to Cmax), respectively. Co‐administration of unesbulin orally at 200 mg or above with DTIC inhibited cytochrome P450 (CYP)1A2‐mediated DTIC metabolism, resulting in 66.7% reduction of AIC exposures. Such inhibition could be mitigated when unesbulin was dosed the day following DTIC infusion. Repeated unesbulin dosing demonstrated evidence of clinical CYP1A2 induction and increased AIC Cmax by 69.4% and area under concentration‐time curve to infinity by 57.9%. No meaningful difference in unesbulin PK was observed between C2 and C1. The combination therapy of 1000 mg/m2 i.v. DTIC q21d and 300 mg unesbulin b.i.w. in a staggered regimen is well‐tolerated in patients with LMS.
Outcomes of intermediate or high‐risk CMML patients treated with hypomethylating agents combined with venetoclax: A single center experience
Authors: Li Chao , Deng ChengXin , Wu Ping , Liu KaiFan , Huang Xin , Li MingMin , Chen XiaoMei , Geng SuXia , Lai PeiLong , Weng JianYu , Du Xin 
Published: December 2023

AbstractChronic myelomonocytic leukemia (CMML) treatment remains a pressing clinical challenge. We conducted a retrospective analysis on 52 CMML cases, exploring the effectiveness of combining venetoclax (Vene) with hypomethylating agents (HMAs). The study's findings show promise: the HMAs plus Vene group (n = 13, 53.8%) demonstrated superior overall response rates compared to the HMA monotherapy (mono) group (n = 19, 31.6%) and HMA plus arsenic trioxide group (n = 9, 22.2%) by the second cycle, and notably higher response rates (53.8% vs. 15.7%, p = 0.04) compared to the HMA mono group after four cycles. Over a median follow‐up of 14.7 months, the HMAs plus Vene group exhibited significantly lower cumulative mortality (23.1%) compared to the other two groups (p = 0.003 and p = 0.008, respectively). Furthermore, this group displayed extended overall survival compared to the others. The study also delved into the molecular mechanisms, revealing significant BCL2 mRNA overexpression in patients with CMML. These findings suggest the potential for HMAs combined with Vene therapy in CMML but emphasize the necessity for further prospective studies to determine its precise role in managing CMML.