bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome‐wide association and environmental suppression of the mortal germline phenotype of wild C. elegans
Authors: Frézal Lise , Saglio Marie , Zhang Gaotian , Noble Luke , Richaud Aurélien , Félix Marie‐Anne 
Published: November 2023

AbstractThe animal germline lineage needs to be maintained along generations. However, some Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to sterility after several generations at 25°C. Using a genome‐wide association approach, we detect a significant peak on chromosome III around 5 Mb, confirmed by introgressions. Thus, a seemingly deleterious genotype is maintained at intermediate frequency in the species. Environmental rescue is a likely explanation, and indeed associated bacteria and microsporidia suppress the phenotype of wild isolates as well as mutants in small RNA inheritance (nrde‐2) and histone modifications (set‐2). Escherichia coli strains of the K‐12 lineage suppress the phenotype compared to B strains. By shifting a wild strain from E. coli K‐12 to E. coli B, we find that memory of the suppressing condition is maintained over several generations. Thus, the mortal germline phenotype of wild C. elegans is in part revealed by laboratory conditions and may represent variation in epigenetic inheritance and environmental interactions. This study also points to the importance of non‐genetic memory in the face of environmental variation.
HMBA ameliorates obesity by MYH9‐ and ACTG1‐dependent regulation of hypothalamic neuropeptides
Authors: Park Seokjae , Oh Sungjoon , Kim Nayoun , Kim Eun‐Kyoung 
Published: November 2023

AbstractThe global epidemic of obesity remains a daunting problem. Here, we report hexamethylene bisacetamide (HMBA) as a potent anti‐obesity compound. Peripheral and central administration of HMBA to diet‐induced obese mice regulated the expression of hypothalamic neuropeptides critical for energy balance, leading to beneficial metabolic effects such as anorexia and weight loss. We found that HMBA bound to MYH9 and ACTG1, which were required for the anti‐obesity effects of HMBA in both NPY‐expressing and POMC‐expressing neurons. The binding of HMBA to MYH9 and ACTG1 elevated the expression of HEXIM1 and enhanced its interaction with MDM2, resulting in the dissociation of the HEXIM1–p53 complex in hypothalamic cells. Subsequently, the free HEXIM1 and p53 translocated to the nucleus, where they downregulated the transcription of orexigenic NPY, but p53 and acetylated histone 3 upregulated that of anorexigenic POMC. Our study points to a previously unappreciated efficacy of HMBA and reveals its mechanism of action in metabolic regulation, which may propose HMBA as a potential therapeutic strategy for obesity.
Aspects and concerns separation in IS
Authors: Čaplinskas Albertas 
Published: November 2023

The paper discusses howto proceed crosscutting concerns in enterprise information sistems, which include computer-aided as well as manual information processing procedures. It proposes to consider such systems as component systems including diferent level components: business components, information processing components and software components. All components should be treated in an uniform manner and modelled using appropriate use case models. Using the proposed approach, croscutting concerns are tangled with functional concerns at the use case level. After this, software components are implemented using conventional techniques of aspect-oriented programming and other components in the form of guides and manuals how to performmanual and computer-aided procedures.
КОНЦЕПЦІЯ ШЛЮЗОВОГО МОДУЛЯ МІСЯЧНОЇ БАЗИ
Authors: Пустовгаров А.А. , Осіновий Г.Г. 
Published: November 2023

Анотація. Вивчення та дослідження Місяця останнім часом вийшли на новий етап та набувають все більших масштабів. Цей процес, що здійснюється зараз автоматичними міжпланетними станціями, в своєму подальшому розвитку продовжиться пілотованими експедиціями, спочатку – короткочасними, згодом – більш тривалими. Зрештою буде забезпечено постійну присутність людей на поверхні Місяця. Для цього будуть створені місячні бази. Необхідно зауважити, що роль людини в космонавтиці залишиться вирішальною. Зокрема це стосується проведення різноманітної діяльності безпосередньо на поверхні Місяця. При цьому перебування людей забезпечуватимуть герметичні внутрішні приміщення місячних баз, а виходи на поверхню та повернення будуть вимагати наявності спеціальних перехідних відсіків, призначених для сполучення цих приміщень (без їх розгерметизації) з поверхнею Місяця – шлюзових модулів. Метою проведених робіт була розробка концепції одного з таких модулів – шлюзового. Було проведено аналіз стану робіт над шлюзовими модулями у світі, враховано вихідні дані та обмеження, які впливають на конструкцію та характеристики модулю, опрацьовано концепцію його використання, зокрема – визначено функції та необхідне для роботи на Місяці обладнання. Розроблено конструкцію модулю, описано його системи. Орієнтовно обчислено енергоспоживання. Обрано найбільш раціональну компоновку обладнання та систем всередині модуля. Здійснено оцінки конструкції та вигляду скафандру для роботи на поверхні Місяця. В результаті концептуального проєктування було одержано деякі характеристики та сформовано вигляд шлюзового модуля. Описано засоби доставки модуля на Місяць, у тому числі надважка ракета космічного призначення, навколомісячний космічний буксир та посадочна платформа. Концептуальні проробки шлюзового модуля з застосуванням новітніх методів проєктування, зокрема 3D-моделювання, показали, що його характеристики знаходяться на сучасному рівні. Проведені роботи дозволяють зробити висновок про те, що шлюзовий модуль місячної промислово-дослідницької бази – важливий та перспективний засіб вивчення та освоєння Місяця.
Regional brain activity of resting-state fMRI and auditory oddball ERP with multimodal approach in individuals with internet gaming disorder
Authors: Park Minkyung , Jang Joon Hwan , Yoo So Young , Choi Areum , Kim Heejung , Choi Jung-Seok 
Published: November 2023

AbstractBackground and aimsResting-state brain activity may be associated with the ability to perform tasks; however, a multimodal approach involving resting-state functional magnetic resonance imaging (fMRI) and event-related potentials (ERPs) has not been widely used to investigate addictive disorders.MethodsWe explored resting-state fMRI and auditory oddball ERP values from 26 with internet gaming disorder (IGD) patients and 27 age- and intelligence quotient-matched healthy controls (HCs). To assess the characteristics of resting-state fMRI, we calculated regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional amplitude of low-frequency fluctuation (fALFF); we also calculated the P3 component of the ERPs.ResultsCompared with HCs, the individuals with IGD exhibited significant decreases in ReHo and fALFF values in the left inferior occipital gyrus, increased ReHo and ALFF values in the right precuneus, increased ALFF in the left superior frontal gyrus, and lower P3 amplitudes in the midline centro-parietal area during the auditory ERP task. Furthermore, the regional activity of resting-state fMRI in the right inferior temporal gyrus and the occipital regions were positively correlated with the P3 amplitudes in IGD patients, whereas ReHo values of the left hippocampus and the right amygdala were negatively correlated with P3.Discussion and conclusionsOur results suggest that IGD patients have difficulty interacting effectively with cognitive function and sensory processing, although its interpretations need some cautions. The findings in this study will broaden the overall understanding of the neurobiological mechanisms that underlie IGD pathophysiology.
Vegetation Structure and Composition of Coffee Agroforestry in Kalibaru District
Authors: Pribadi Titanio Auditya , Afiyanti Mufidah , Hakim Luchman 
Published: November 2023

Agroforestry is a form of sustainable agriculture; the present threat of agroforestry is a change in agroforestry landforms that have switched to a less sustainable form. Coffee plays a role in the agroforestry ecosystem, Kalibaru is one of the Banyuwangi District coffee centers managed by the local community. The objective of this study was to determine the vegetation structure and analyze the effect of that on environmental parameters. Data was collected by vegetation analysis and soil parameter analysis with PAST 2020 Software version 4.05. In total, 15 research plots were used, consisting of 5 complex agroforestry, 5 simple agroforestry, and 5 monoculture plots. The results showed 20 species in complex agroforestry, 24 species in simple agroforestry, and 18 species in monoculture were found. The highest important index level in complex agroforestry: Durio zibethinus 63.87% for trees, the Swietenia mahagoni 64.43% for poles, and Coffee canephora 128.87% for shrubs. In simple agroforestry : Cocos nucifera 72.83% for trees, Leucaena leucocephala 80.70% for poles, and the Coffea canephora 137.57% for shrubs. In monoculture agroforestry: Hibiscus similis 82.99% for trees, Leucaena leucocephala 209.22% for poles, and Coffea canephora 130.96% for shrubs. Agroforestry in Kalibaru was categorized in the moderate diversity. The diversity index (H') in complex agroforestry showed H' trees 2.21, pole 2.03 and. shrubs 1.60. Simple agroforestry shows H' tree 2.00, pole 2.49, and shrubs 1.50. Monoculture shows H' tree 1.98, pole 0.64, and shrubs 1.54. Agroforestry a role in maintaining soil moisture and temperature, complex agroforestry: temperature 24 0C, and Moist 5.82, simple: temperature 24.2 0C, Moist 5.42, and Monoculture temperature 26 0C, Moist 4.54.
In Silico Analysis of Catechin, Galangin, and Hesperidin as Competitors of the SARS-CoV-2 Spike Protein
Authors: Kusumorini Astuti , Hasna Nisrina , Suryani Yani , Taufiqurrahman4 Opik 
Published: November 2023

Currently, Covid-19 has become endemic. However, the development of Covid-19 drugs continues to be carried out to suppress the growth of the Sars-Cov-2 virus. Some compounds with antiviral activity are catechin, galangin, and hesperidin. Angiotensin-converting enzyme-2 (ACE-2) is a protein that enters viruses into the cell. Based on that, ACE-2 can be used as a primary target to suppress the development of the Sars-Cov-2 virus. This study aimed to test the catechin, galangin, and hesperidin compounds in inhibiting the SARS CoV-2 virus from attaching to ACE-2 by trying the interactions of catechin, galangin, and hesperidin compounds with ACE-2 using the in-silico method. The material used was the three-dimensional structure of the compounds catechin, galangin hesperidin, and ACE-2. The tools used were FAF-Drugs4, Discovery Studio, and Pyrex software. Low-affinity energy values (kcal/mol) indicate promising results. The results showed that the energy affinity value of catechin was -6.2 kcal/mol, galangin was -6.3 kcal/mol, and hesperidin was -8.3 kcal/mol. This value is lower than the control affinity energy (chloroquine and favipiravir), which is -5.2 kcal/mol and -4.8 kcal/mol, respectively. Based on this, catechin, galangin, and hesperidin can be used as inhibitors/competitors for the Sars-Cov-2 to attach to ACE-2.
Pengukuran Listrik Jaringan Tegangan Rendah Secara Online dengan Mikrokontroler ESP32 di PLN UP3 Surabaya Selatan dan UP3 Surabaya Utara
Authors: Sudewanto Suhardhika Sih , Hasan Fuad , Riyadi Munawar A 
Published: November 2023

Keandalan dan pelayanan prima di sistem jaringan tegangan rendah menjadi tolok ukur kinerja PLN terhadap kepuasan pelanggan. Di sistem jaringan tegangan rendah, kondisi trafo di gardu distribusi perlu dipantau. Kondisi trafo dan pemantauan profil beban berkontribusi pada respon tindakan yang perlu dilakukan untuk mempertahankan kinerja trafo. Saat ini, pemantauan profil beban trafo masih dilakukan secara manual oleh personel pemeliharaan secara periodik, yang sulit memberikan gambaran kondisi secara presisi. Untuk itu, diusulkan pemantauan profil beban trafo secara online di PLN UP3 Surabaya Selatan and UP3 Surabaya Utara. Pemantauan secara online berbasis mikrokontroler ESP32. Dari hasil uji coba, peralatan monitoring dapat memberi informasi profil beban yang detail sesuai urutan waktu, serta nilai benefit to cost ratio 1. Dengan demikian, implementasi peralatan monitoring online layak untuk diterapkan di gardu distribusi yang memberi kemudahan monitoring kondisi trafo secara real time sekaligus memberikan manfaat efisiensi biaya operasional. Reliability and excellent service in the low voltage network system are benchmarks for PLN's performance in terms of customer satisfaction. In a Low Voltage Network System, the transformers status at distribution substations needs to be monitored. Transformer condition and load profile monitoring contribute to the response actions to maintain transformer performance. Currently, monitoring of transformer load profiles is still carried out manually by maintenance personnel periodically, which does not provide a precise picture of network conditions. We propose online monitoring system for transformer load profiles at PLN UP3 South Surabaya and UP3 North Surabaya. The online monitoring process was based on the ESP32 microcontroller. The test results show that monitoring equipment can provide detailed load profile information to time sequence and a benefit to cost ratio value of 1. Thus, the implementation of online monitoring equipment is suitable for application in distribution substations that makes it easy to monitor transformer conditions in real time while providing efficiency benefits.
"Participation and Atonement: An Analytic and Constructive Account " by Oliver D. Crisp and "Total Atonement: Trinitarian Participation in the Reconciliation of Humanity and Creation" by W. Ross Hastings
Authors: Keogh Benjamin 
Published: November 2023

Reviewed works:
Oliver D. Crisp, Participation and Atonement: An Analytic and Constructive Account (Grand Rapids, MI: Baker Academic, 2022), pp. xi + 259, ISBN 978-0801049965. £19.99
W. Ross Hastings, Total Atonement: Trinitarian Participation in the Reconciliation of Humanity and Creation (London: Rowman & Littlefield, 2022), pp. 320, ISBN 978-1978702158. £35.00
Parafia rzymskokatolicka pw. św. Marcina w Nowym Mieście po II wojnie światowej na terenie USSR w świetle źródeł sowieckich
Authors: Kapłon Marcin 
Published: November 2023

Artykuł ukazuje powojenne losy parafii pw. św. Marcina w Nowym Mieście, która przed II wojną światową leżała w granicach diecezji przemyskiej i należała do jednych z najstarszych (powstała przed 1419 r.). Niestety, na skutek nowej sytuacji politycznej znalazła się ona – podobnie jak znaczna część diecezji przemyskiej – w granicach Związku Radzieckiego, w którym władze komunistyczne prowadziły agresywną walkę z religią. Represje ateistycznego systemu dosięgły również rzymskokatolicką parafię w Nowym Mieście. Swoje przetrwanie i możliwość funkcjonowania w sowieckiej rzeczywistości zawdzięcza ona przede wszystkim postawie niezłomnego pasterza – ks. Jana Szeteli oraz grupie wiernych, którzy mimo opresyjnej polityki państwa wobec wierzących wzięli odpowiedzialność za utrzymanie jednej z ostatnich na tym terenie placówki duszpasterskiej. To właśnie o tych zmaganiach i heroicznej postawie ludzi opowiada artykuł. Bazuje on przede wszystkim na materiale źródłowym pochodzącym z Państwowego Archiwum Obwodu Lwowskiego we Lwowie i właśnie to stanowi o jego oryginalności, gdyż w zasadzie dokumenty te w bardzo nikłym stopniu (niektóre jako kopie przechowywane w kancelarii parafialnej) były wykorzystywane przy opisywaniu parafii w Nowym Mieście w okresie systemu komunistycznego bądź niezłomnej postawy jej duszpasterza – ks. Jana Szeteli.
Carbon Dioxide Monitoring Demonstrates Variations in the Quality of Ventilation on Public Transportation Buses and University Student Shuttle Vans and Identifies Effective Interventions
Authors: Greentree David Henry , Wilson Brigid M , Donskey Curtis J 
Published: November 2023

Background: There is a risk for transmission of severe acute respiratory syndrome 2 (SARS-CoV-2) and other respiratory viruses in motor vehicles, particularly if ventilation is inadequate.
Methods: We used carbon dioxide monitoring to examine the quality of ventilation in several public transportation buses and in university student shuttle vans in the Cleveland metro area during peak and non-peak travel times. Carbon dioxide levels above 800 parts per million (ppm) were considered an indicator of suboptimal ventilation for the number of people present. In the shuttle vans, we evaluated the impact of an intervention to improve ventilation.
Results: In large articulated buses with 2 ventilation systems, carbon dioxide concentrations never exceeded 800 ppm, whereas in standard buses with 1 ventilation system concentrations rose above 800 ppm during peak travel times and on some trips during non-peak travel times. In shuttle vans, the ventilation system was not turned on during routine operation, and carbon dioxide levels rose above 800 ppm on all trips during peak and non-peak travel times. In the shuttle vans, an intervention involving operation of the existing ventilation system resulted in a significant reduction in carbon dioxide levels (mean concentration, 1,042 no intervention versus 785 with intervention; P<0.001).
Conclusion: Our findings demonstrate substantial variability in the quality of ventilation in public transportation buses and university shuttle vans. There is a need for efforts to assess and optimize ventilation in motor vehicles used for public transportation to reduce the risk for aerosol-mediated transmission of respiratory viruses. Carbon dioxide monitoring may provide a useful tool to assess and improve ventilation.
Evaluación del impacto en la salud (EIS) del transporte urbano: su aplicación en Medellín = Health impact assessment (HIA) of urban transport: Its application in Medellin
Authors: Sierra Valdivieso Lorena 
Published: November 2023

ResumenLas condiciones del planeamiento urbano y el transporte de las ciudades impactan en la salud de sus habitantes. El artículo revisa los diferentes modelos de evaluación del impacto en la salud (EIS) del transporte urbano y explora su aplicación en Medellín. Los modelos utilizados para análisis cuantitativos EIS siguen un método de comparación de riesgos, estimando el peso global de una enfermedad y comparándolo con el valor recomendado por la comunidad científica. Para el caso de Medellín, se explora la combinación de dos modelos que estudian el número de muertes prevenibles si se alcanzan los niveles recomendados de: actividad física, contaminación del aire, ruido, aumento de temperaturas, acceso a áreas verdes y accidentes de tráfico fatales. A pesar de las limitaciones, los resultados obtenidos con modelos EIS pueden orientar la toma de decisiones y promover niveles de exposición que favorezcan la prevención de muertes prematuras. Abstract Urban and transport planning conditions in cities have an impact on the health of their inhabitants. This research reviews the different models of health impact assessment (HIA) of urban transport and explores their application in Medellín. Quantitative HIA models consider a risk comparison method, estimating the global burden of disease and comparing it with the value recommended by the scientific community. For Medellin, the combination of two models is explored to study the number of preventable deaths when reaching the recommended levels of: physical activity, air pollution, noise, increased temperatures, access to green areas and fatalities. Despite the limitations, results from EIS models can guide decisions making and promote exposure levels that favor the prevention of premature deaths.
(In)justicia social en el acceso a la vivienda en alquiler en España: administración pública, movilización social e impacto de la pandemia = Social (in)justice in access to rental housing in Spain: Public administration, social mobilization and the impact of the pandemic
Authors: Brito Doerr Marisol 
Published: November 2023

Resumen El incremento de la demanda de vivienda en régimen de alquiler tras la crisis del 2008, junto a la entrada de fondos de inversión, provocó el alza de los precios y supuso un aumento de los lanzamientos por impago de alquiler. La situación provocada por el Covid-19 le dio a la vivienda un papel significativo, evidenciado la precariedad del inquilinato frente al acceso a una vivienda. Este artículo analiza en qué medida las políticas y prácticas llevadas a cabo por los distintos actores en relación a la vivienda en régimen de alquiler han contribuido a promover la (in)justicia socioespacial, y cómo esta se ha visto afectada por la pandemia. Para ello, se ha elaborado un marco analítico basado en la teoría critica de justicia social de Nancy Fraser que se ha aplicado a tres casos de estudio. Se concluye que la vivienda en régimen de alquiler tiene un enorme potencial para asegurar el derecho a una vivienda digna y, por tanto, promover la redistribución de recursos, sin embargo, esto no ocurrirá si no hay reconocimiento previo en los discursos y representación equitativa en la toma de decisiones de todos los actores. Abstract The increase in the demand for rental housing after the 2008 crisis, together with the entry of investment funds, caused prices to rise and led to an increase in evictions due to non-payment of rent. The situation caused by Covid-19 gave housing a significant role, evidencing the precariousness of tenancy as opposed to access to housing. This article analyzes to what extent the policies and practices carried out by different actors in relation to rental housing have contributed to promote socio-spatial (in)justice, and how this has been affected by the pandemic. To this end, an analytical framework based on Nancy Fraser's critical social justice theory has been developed and applied to three case studies. It’s concluded that rental housing has an enormous potential to ensure the right to decent housing and therefore promote the redistribution of resources, however, this will not happen if there is no prior recognition in the discourses and equitable representation in decision-making of all actors.
How Were European GPS/FPS Involved in the COVID Vaccination-Campaign? A European Questionnaire Study About the Experiences of the Vaccinations in 2021
Authors: RURIK Imre , TORZSA Péter 
Published: November 2023

Background. The SARS-CoV-2pandemic has become the greatest public health challenge worldwide. Intensive research started to develop vaccines and by the late 2020 vaccination campaign started.
Objective. Collecting information from European countries, how and in what extent were family physicians/general practitioners/FPs/GPs involved in the vaccinations-campaign in 2021 and how was it organized at national level.
Method. A short questionnaire was distributed through the secretariats of WONCA-Europe and the European Forum for Primary Care.
Results. In most of the countries participation of FPs/GPs was compulsory. The vaccination was usually centrally organized by governmental authorities. At the beginning (web-based) registration of patients was required, mainly at national level. By the mid of 2021, vaccination on walk in basis became available in almost every country for the first and for the booster injections. The remunerations of GPs/FPs were differed, in some countries without extra payment. The Pfizer’s vaccine was used in all countries; while in 9 countries not EMA approved vaccines were also used in primary care settings and at vaccination centres. In some countries, professional homepages helped the GPs.
The involvement of PHC providers did not correlate to the vaccination coverage of the entire population of the respective countries. It was the highest in the more developed countries with higher living standard, where participation of GPs was voluntary and appropriate financial incentives were offered for them.
Conclusion. The vaccination campaign was a professional and logistic challenge and an excellent performance of PC providers. Experiences gained could be used in the future to manage similar pandemic challenges.