bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Adsorption Ability of Cibacron Red Dye from Aqueous Solution Using Copper Oxide Nanoparticles
Authors: Khanjar Aya Qasim , Farhan Ahlam Mohammed , Rheima Ahmed Mahdi 
Published: November 2023

يصف هذا البحث الإنتاج الصديق للبيئة لجسيمات النحاس النانوية باستخدام مستخلص نبات الجرجير والحرق عند درجة حرارة 400 درجة مئوية لمدة 3 ساعات. تم استخدام SEM و TEM لتحليل حجم الجسيمات النانوية المحضرة. تم استخدام حيود الأشعة السينية لتحديد الهيكل البلوري. كشف التحليل الطيفي للأشعة السينية المشتتة للطاقة لهيكل المنتج الذي تم إنشاؤه عن مكونات النحاس والأكسجين فقط ، مما يدل على نقاء المادة المحضرة. استخدمت المادة النانوية المحضرة CuO NPs في امتزاز صبغة Cibacron الحمراء. في 35 دقيقة من زمن الاتزان ، لوحظ امتزاز أسرع لصبغة Cibacron الحمراء على الجسيمات النانوية CuO . كان نموذجا Freundlich و pseudo-second ذات قيم R2 أكثر من 0.9785 و 0.999 على التوالي ، الأكثر فاعلية في وصف عملية الامتزاز. تم حساب المعلمات ΔG, ΔH, ΔS. يمكن الاستنتاج أن CuO NPs هي سطح ممتز فعال لصبغة Cibacron الحمراء.
A Dislocated Quasi-Normed Space and Its Completeness for A Fixed Point Theorem
Authors: Al-Delfi Jawad Kadhim K. 
Published: November 2023

تم تقديم مفهوم الفضاء شبه المعياري المشتت في هذا البحث وهو حالة خاصة لمفهوم الفضاء شبه المعياري ومرتبط بمفهوم الفضاء شبه المتري المشتت. العلاقة بين هذا المفهوم والمفاهيم الأخرى أعطيت من خلال أمثلة توضيحية. مفهوم شبه بناخ المشتت هو شبه المعياري المشتت الكامل والتي يعتبر مهم لنتائجنا فيما يتعلق بنظرية النقطة الصامدة. أيضًا، يتم تقديم التقابل شبه انكماشي، الذي فيه ثابت ليبتشيتز يعتمد على ثابت الفضاء شبه المعياري المشتت، ثم ندرس نظرية بناخ الانكماشية في شبه بناخ المشتت مع بعض النتائج المهمة.
Th9 cytokines inhibit proliferation, promote apoptosis, and immune escape in thyroid carcinoma cells
Authors: Ying Xinyu , Ma Xinyi , Yang Ziru , Zhou Bo 
Published: November 2023

Abstract
Objective: To investigate the regulatory effects of T helper 9 (Th9) cytokines on the proliferation, apoptosis and immune escape of thyroid cancer cells.
Methods:The survival rate of human thyroid cancer cell line TPC-1 after treatment with 0, 1, 2.5, 5, 10, 20 ng/ml IL-9 (or IL-21) was determined by CCK-8 method and suitable concentrations of IL-9 and IL-21 were screened out. The TPC-1 cells cultured in vitro were randomly grouped into control group, IL-9 group, IL-21 group and IL-9+IL-21 group. After treatment with IL-9 and IL-21 factors, the proliferation and apoptosis of TPC-1 cells in each group were detected by CCK-8 method and flow cytometry respectively. The flow cytometry was applied to detect the proportion of Th9 and activated CD8+ T cells in human peripheral blood lymphocytes co-cultured with TPC-1 in each group. The expression of TPC-1 and IL-9R and IL-21R protein in each group and human peripheral blood lymphocytes.
Results: Compared with the control group, the cell viability PCNA and Bcl-2 protein expression in TPC-1 cells were lower in the IL-9 group, IL-21 group and IL-9+IL-21 group (P<0.05). The apoptosis rate, proportions of Th9 and activated CD8+ T cells, killing rate of human peripheral blood lymphocytes, the expression of Bax and caspase-3 proteins in TPC-1 cells, the expression of TPC-1 and human peripheral blood lymphocytes IL-9R and IL-21R proteins were all higher (P<0.05) in IL-9+IL-21 group compared with the IL-9 group and the IL-21 group. The cell viability, PCNA and Bcl-2 protein expression in TPC-1 cells in the IL-9+IL-21 group were all lower (P<0.05).
Conclusion:Th9 cytokines can promote the differentiation of Th9 cells and CD8+ T cells, enhance their lethality, reduce the immune escape of thyroid cancer cells, and then inhibit their proliferation and promote their apoptosis.
Exploring the Properties of Zr2CO2/GaS Van der Waals Heterostructures for Optoelectronic Applications
Authors: Abdul Abdul , Khan Altaf Ur Rahman , Bo Jing , Khan Jehan Akbar , Abbasi Qammer H. , JingFu Bao 
Published: November 2023

Abstract
We investigate the structural, electronic and optical properties of eight possible Zr2CO2/GaS van der Waals heterostructures using first-principles calculations. These structures display favorable stability, indicated by matching crystal structures and a negative formation energy (-6.57 eV). In all configurations, they act as indirect bandgap semiconductors with a type-II band alignment, allowing eﬀicient electron- hole separation. Optical studies reveal their suitability for optoelectronic applications. Zr2CO2/GaS under 3% biaxial compressive strain meets the criteria for photocatalytic water splitting, suggesting their potential for electronic and optoelectronic devices in the visible spectrum. Our findings present prospects for advanced photocatalytic materials and optical devices.
Sustainable sewage water treatment based on natural plant coagulant: Moringa oleifera (Moringa Seeds)
Authors: Shabani Nzeyimana Bahati , Mary A.Daisy Caroline 
Published: November 2023

Abstract
Sustainable sewage water treatment is becoming increasingly important in the current global scenario of water scarcity and environmental degradation. One promising technique in natural plant coagulation that has gained attention in recent years is the use of Moringa oleifera for wastewater treatment. The statement of my study was to investigate the effectiveness of Moringa oleifera in reducing turbidity and impurities in sewage water using a jar test as a qualitative technique in coagulant and flocculation, analyze physical and chemical parameters for raw water and treated water, the optimum dose shown to treat water was 0.4g/1000ml. The obtained result indicated that Moringa oleifera is effective in reducing turbidity respectively by 92%, COD by 88%, Total solids by 96%, Chloride by 75%, Total hardness by 74%, Inorganic phosphorous by 68%, and BOD found. This study concludes that the use of Moringa oleifera for sustainable sewage water treatment is a promising green technique that has the potential to contribute more benefit to people, moringa oleifera as NPC for water treatment can lead to significant improvements in the quality of water and the health of societies while also promoting sustainability and environmental harmony.
Economic benefits may be the main driver of secondary metal production
Authors: PAN HUA , Guo Tianjiao 
Published: November 2023

Abstract
The current scientific community regards secondary metal production not only as a solution that may alleviate future resource shortages but also as an effective way to achieve energy savings and reduce environmental pollution. However, such studies usually assumes a linear value chain and ideal production conditions with high grades of scraps. More evidence needs to be provided to demonstrate the advantages of secondary production over primary production. In this work, we conducted an empirical analysis through production data of 6 categories of metals from 44 countries and 5 rest-of-the-world regions from 1995 to 2015, so as to partially illustrate the actual difference between primary production and secondary production in the world. Results show that secondary production has an advantage only in terms of economic profitability, and lags behind primary production in terms of energy demand, greenhouse gas emissions, and resource efficiency. We explored the reason for contradiction with the mainstream viewpoint, and discussed influencing factors and implications of our results. This study reveals the importance of both contextualization and globalization when establishing circular economy strategies and more sustainable metals management.
Benchmarking whole exome sequencing pipeline for predicting pathogenic variants of significance
Authors: Raju Ranjana Mariyam , Singh Ujjwal Prathap , Suravajhala Prashanth 
Published: November 2023

Abstract
Benchmarking whole exome pipelines is crucial for evaluating and comparing their performance in variant calling and clinical significance annotation. It enables researchers and clinicians to assess the accuracy, sensitivity, and specificity of different pipelines and identify the most effective and reliable ones. In this study, we evaluated and compared the performance of our in-house consensus exome pipeline with a widely recognized gold standard Genome Analysis Toolkit (GATK) pipeline. Four datasets were used for evaluation, three 1000 Genome Project (1KGP) datasets and one Prostate cancer (PCa) Sample. The consensus pipeline consistently demonstrated a higher average transition-to-transversion (Ti/Tv) ratio, indicating enhanced precision in identifying single nucleotide variant (SNV) calls. This suggests that the consensus pipeline excels in effectively discerning true genetic variations from sequencing artefacts, particularly in the context of exome sequencing. Additionally, the pipeline exhibited increased sensitivity in detecting pathogenic and likely pathogenic variants in the PCa sample, further highlighting its efficacy in identifying clinically relevant variants. We also conducted a trio exome analysis with the use of two trio pipelines, viz. VarScan Trio and GATK joint calling pipelines on our erstwhile Congenital Pouch Colon (CPC) samples from our rare disease cohort which we published earlier and found that the GATK predicted a significantly higher number of variants compared to VarScan. Our study demonstrates a large potential for trio-variant calling analysis paving the way for precision medicine.
Factors associated with social participation among community-dwelling frail elderly people in Japan
Authors: anzai Saori , ohsugi Hironori , shiba Yoshitaka 
Published: November 2023

Abstract
Background
In recent years, it has become clear that participation in social activities by the elderly suppresses their need for long-term care. Likewise, social participation can promote long-term care prevention among frail elderly individuals who are at a higher risk of needing long-term care. However, their social participation rate is low, and the factors causing these low rates of participation are unclear. Therefore, this study identifies the factors affecting social participation of frail elderly people.
Methods
After excluding those certified as requiring long-term care, 28,636 elderly individuals within the target region were selected to receive questionnaires. The questionnaires were distributed and collected via mail. A total of 22,048 respondents (77.0%), including 9,325 men and 10,150 women, were included; 2,655 frail elderly individuals were identified for analysis. Questionnaire items inquired about social participation, basic attributes, need for long-term care, mobility, subjective health, direct and indirect contact with relatives living separately and direct and indirect contact with friends and neighbors. For the statistical analysis, this study employed a binomial logistic regression analysis with social participation as the objective variable.
Results
The rate of social participation among frail elderly individuals was 13.7%. Items related to social participation included sex, economic status, mobility, objective health, direct contact with friends, and indirect contact with friends.
Conclusions
Interactions with friends and neighbors and physical functionality are correlated with levels of social participation among frail elderly people, suggesting that social participation can be promoted by maintaining friendships, forming new ones, and maintaining and improving physical functionality.
Evaluation of Serum Levels of Ischemia Modified Albumin in a Nigerian Population with Primary Hypertension
Authors: Ochiogu Peace O. , Nwosu Smart , Esiaba Ijeoma 
Published: November 2023

Abstract
Objectives: Levels of Ischemia Modified Albumin (IMA) were determined in pre-hypertensives and hypertensives to possibly identify those at a greater risk of ischemic organ damage.
Methodology: Eighty-four (84) participants were recruited for this study. They were divided into three groups of 28 participants each based on their blood pressure namely normotensive, pre-hypertensive, and hypertensive. Demographic details of the participants were obtained using a questionnaire. The levels of IMA, serum lipid profile (total cholesterol, triglycerides, High Density Lipoprotein-cholesterol (HDL-c), and Low-Density Lipoprotein-cholesterol (LDL-c)), fasting blood glucose, serum electrolytes, urea, creatinine, and albumin, the ratio of triglyceride to HDL-c (TG-HDL-c), and triglyceride-glucose index (TyG) were investigated. Data obtained were analyzed using descriptive statistics, one-way analysis of variance (ANOVA), Pearson’s Chi-square test, partial correlations, and receiver operating characteristic (ROC) statistics. Statistical significance was set at P < 0.05.
Results: Levels of IMA were significantly elevated in the hypertensive group. After adjusting for age and BMI, IMA showed a significant positive correlation with systolic blood pressure, partial pressure, albumin, glucose, total cholesterol, LDL-c, and TG-HDL-c but a negative correlation with HDL-c and potassium. IMA also demonstrated a discriminative ability for elevated blood pressure with an ROC area under the curve of 0.75. With a cut-off value of 0.36 ABSU, it had a sensitivity of 0.64, specificity of 0.86, and Youden J index of 0.49.
Conclusion: Elevated IMA levels were correlated with biomarkers of dyslipidemia, dysglycemia, and insulin resistance. IMA levels could be used as a predictive marker of cardiovascular diseases related to ischemia and can help flag individuals at risk, thereby facilitating early treatment interventions.
The Quality of RF Signal Communication Performance of LoRa-RSSI Analysis Based on Various Environments Tests
Authors: Boonsong Wasana , Inthasuth Tanakorn , Kannan Umapathy 
Published: November 2023

Abstract
The impact of signal quality in smart farming based on the Internet of Things (IoT) regarding the innovative farm requires a wide area for collecting data from an agriculture plot. According to many wireless device technologies used in an intelligence farming project, improving radio frequency (RF) signal communication is a crucial issue. This article proposes the signal quality of RF communication using LoRa technology, analyzing the strength signal measurement in different locations. These experiments test the strength signal in dBm and data received efficiency in percentage. The investigation is designed to collect received signal strength indicator (RSSI) value tests in different environments: seaside, grape farm, and indoors. The measured RSSI values in several tests are averaged to determine the reliability of RSSI results. The findings indicated that the location with less RSSI value is inside the building compared to other places, such as the seaside area or the grape farm. By overview of quality received signal strength is at the reasonable level between RSSI values of -60.00 dBm to -80.00 dBm. Moreover, the correlation analysis of the RSSI value and data received effectively is 0.938**, with the reliability of data analysis of 99%. Namely, both parameters are highly related in a positive way. When the RSSI value is high, the data received effectively is also in good condition.
Compositions of clinopyroxene solid solutions in Di-CaEs section of CMAS system at pressure up to 3.0 GPa
Authors: Banushkina Sofja V. 
Published: November 2023

Abstract
The possibility of ‘excess’ silica dissolution in clinopyroxene as calcium molecule of Eskola (CaEs) end member has been known for a long time. At present time attempts to determine the dependence of such non-stoichiometric clinopyroxene compositions on (P, T)-parameters are continued. In this article Di-CaEs section of ‘dry’ CMAS system was investigated in P-T range of up to 3.0 GPa and up to 1550 oC. Experiments with synthetic clinopyroxene compositions were carried out on a vertical shaft electric resistance furnace with silicon carbide heaters (at atmospheric pressure) and were run by quenching method on the piston-cylinder apparatus (at high pressure). It was found that two independent stable pyroxene phases are formed: aluminous clinopyroxene and a high-magnesian alumina-free diopside. It was clarified that clinopyroxene solid solution is represented by a quad series of Di-En-CaTs-CaEs end members. It was shown that diopside phase belongs to Di-En solid solution. A tetrahedron of clinopyroxene compositions was constructed, occupying a central position in CMAS system. Experimental data obtained can serve as a necessary model for subsequent studying influence of alkalis, ferruginous component, etc. on stability of quartz-normative mineral associations and identical ‘real’ parageneses.
Association of preoperative NT-proBNP with postoperative inflammatory factors levels among children of unrestricted left-to-right shunts congenital heart disease
Authors: Li Wen-Juan , Shang Wen-yuan , Lu Ya-Nan , Huang Ji-hong 
Published: November 2023

Abstract
This study aimed to evaluate preoperative N-terminal pro-B-type natriuretic peptide (NT-proBNP) in children with pulmonary arterial hypertension (PAH) secondary to unrestricted left-to-right shunts congenital heart disease (CHD) and sought to investigate the correlation between NT-proBNP and inflammatory factor levels following cardiac surgery with cardiopulmonary bypass (CPB). A retrospective observational study was conducted involving 59 infants or children under 2 years old. Echocardiography was employed to measure tricuspid annular peak systolic velocity (TRV). The plasma of preoperative NT-proBNP and perioperative inflammatory cytokines, including IL-6, IL-8, IL-10, IL-1β, and TNF-α were measured. Additionally, postoperative ventilation time, length of Intensive care unit (ICU) and ward stay were recorded. Longer postoperative ventilation time, ICU stay and ward stay exhibited in PAH-CHD patients, and elevated preoperative NT-proBNP levels were associated with preoperative pulmonary artery systolic pressure (PASP). Moreover, there was a significant increase in postoperative inflammatory cytokines, including IL-6, IL-8 and IL-10 (p＜0.05). Importantly, preoperative NT-proBNP was identified as being associated with inflammatory cytokines levels after surgery.
Conclusion: Preoperative NT-proBNP level was associated with PASP before surgery in children with unrestricted left-to-right shunts PAH-CHD, and elevated preoperative NT-proBNP levels were associated with significantly increased inflammatory factors after CPB, suggesting a potential correlation with early poor postoperative clinical outcomes.
Impact of Oral Health Status on Oral Health– Related Quality of Life among Institutionalized Elders in EL-Gharbiya Governorate
Authors: Dosoky Ahmed El 
Published: November 2023

Abstract
Background
Aging process may directly or indirectly increase the risk of developing diseases. It may develop a large number of pathological and/or physiological changes that could influence dental treatments. In Egypt number of social welfare institutions for elderly people has increased. Therefore, the aim of the present study was to assess the impact of oral health status on Oral Health– Related Quality of Life, among institutionalized elders in EL-Gharbiya governorate.
Methods
The Brief Oral Health Status Examination (BOHSE) was used to assess oral health of the institutionalized elders. Oral health related quality of life of the elders was evaluated using Geriatric Oral Health Assessment index. The GOHAI comprises 12 items reflecting three hypothesized domains of the impact of oral disease: Physical function: eating, swallowing, biting and chewing ,Psychological function: satisfaction with appearance, worries or concern about oral health and inhibition of social contacts as a result of such concerns and Pain and discomfort: eating sensitivity to hot, cold or sweets.
Results
Regarding gender, there was a statistically significant negative correlation between geriatric oral health assessment index scores and brief oral health status examination scores among elder females (r = − .267, p = 0.004). Similarly, a statistical significant negative correlation was detected between geriatric oral health assessment index scores and brief oral health status examination scores among elders above 70 years of age (r = − .371, p = 0.002).Moreover, elders residing in private institutions displayed a statistically significant negative correlation between geriatric oral health assessment scores index and brief oral health status examination scores (r = − .252, p = 0.037).
Conclusion
The highest proportion of oral health problems among the institutionalized elders were oral cleanliness and gum problems (84.7%&76%) respectively. 66.8% of the participants reported a low oral health-related quality of life. Elders reporting a moderate and high oral health-related quality of life represented 20.3% and 12.9% respectively. A significant negative correlation between oral health and oral-health related quality of life was identified among institutionalized elders.
Evaluation of molecular docking by deep learning and Random Forests: A hybrid approach based on pseudo-convolutions
Authors: Ferreira Janderson Romário Borges Cruz , Feitosa Allan Rivalles Souza , Gomes Juliana Carneiro , Silva-Filho Abel Guilhermino , Santos Wellington Pinheiro dos 
Published: November 2023

Abstract
Purpose: Molecular docking prediction plays a pivotal role in intelligent drug design, offering significant advantages in the development of antivirus medications and vaccines. By accurately evaluating the interactions between drug molecules and target proteins, researchers can effectively expedite the discovery and development of vital pharmaceutical solutions, aiding in the mitigation of epidemics, pandemics, and the urgent need for improved vaccines.
Methods: We propose an intelligent hybrid architecture for estimating molecular docking between two proteins using deep networks based on pseudo-convolutions and Random Forests. As input, we Evaluation of molecular docking by deep learning and Random Forests used the sequences of characters representing the bases of each protein. Through two layers of pseudo-convolutions, these sequences are reorganized and, finally, represented as co-occurrence matrices, concatenated into a feature vector. To validate our proposal, we used a combination of the public datasets Affinity Benchmark 3 and Negatome 2.
Results: The experimental results revealed that the hybrid architecture , comprising two layers of pseudo-convolution followed by a decision layer with an ensemble of 25 Random Forests, yielded average accuracy of 94%, AUC of 93%, sensitivity of 94%, and specificity of 78%. This demonstrates the feasibility of achieving robust estimates of molecular docking without relying on 3D molecule modeling.
Conclusion: These findings the potential of rapidly estimating protein affinity, providing valuable insights into drug interactions, molecular dynamics, and facilitating the intelligent design of pharmaceuticals, encompassing vaccines and antiviral drugs. These advancements play a critical role in cost reduction related to laboratory analysis and expediting the timely delivery of solutions to both the market and society at large, particularly in the context of epidemic outbreaks, pandemics, and the urgent demand for supplementary vaccines.