bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the influence path of the unit environment of medical and health institutions on achievement transformation output
Authors: GAO Yanchao , GU Hua 
Published: December 2023

Objective
To analyze the influence path of the interaction between the unit environment, achievement transformation willingness, and achievement transformation cognition on achievement transformation output to provide a basis for optimizing the achievement transformation environment of medical and health institutions and improving the efficiency of scientific and technological achievements transformation.

Methods
Through the questionnaire survey, 292 data points were obtained. SPSS20.0 was used to conduct cross-table chi-square analysis and binary logistic regression analysis on the willingness, cognition, and output of scientific and technological achievements transformation. The process 14.0 plug-in is used to analyze the mediating effect of transformation cognition and the moderating effect of the unit environment.

Results
Achievement transformation willingness has a significant positive impact on achievement transformation cognition and achievement transformation output. Achievement transformation cognition has a positive impact on achievement transformation output, and the mediating effect of transformation cognition is significant and partial. The unit environment has a negative moderating effect on the influence of achievement transformation willingness on achievement transformation cognition, and a positive moderating effect on the influence of achievement transformation willingness on achievement transformation output.

Conclusion
Personal factors and unit achievement transformation environment have an obvious influence on the willingness and cognition of achievement transformation. It is necessary to optimize the environment of unit scientific and technological achievements transformation, improve the policy system of benefiting from the achievements of scientific and technological achievements transformation of medical and health personnel, implement the disposal right, income right and distribution right of scientific and technological achievements transformation of medical and health institutions, and stimulate the enthusiasm of scientific and technological achievements transformation of medical and health personnel.
Friendship interventions for children with neurodevelopmental needs: A systematic review and meta-analysis
Authors: Cordier Reinie , Parsons Lauren , Wilkes-Gillan Sarah , Cook Matthew , McCloskey-Martinez Matthew , Graham Pamela , Littlefair David , Kent Cally , Speyer Renée 
Published: December 2023

RationaleChildren with neurodevelopmental disorders such as attention-deficit hyperactivity disorder (ADHD), autism, developmental language disorder (DLD), intellectual disability (ID), and social (pragmatic) communication disorder (SPCD) experience difficulties with social functioning due to differences in their social, emotional and cognitive skills. Previous systematic reviews have focussed on specific aspects of social functioning rather than broader peer functioning and friendships.ObjectiveTo systematically review and methodologically appraise the quality and effectiveness of existing intervention studies that measured friendship outcomes for children with ADHD, autism, DLD, ID, and SPCD.MethodFollowing PRISMA guidelines, we searched five electronic databases: CINAHL, Embase, Eric, PsycINFO, and PubMed. Two independent researchers screened all abstracts and disagreements were discussed with a third researcher to reach consensus. The methodological quality of studies was assessed using the Cochrane Risk of Bias Tool for Randomised Trials.ResultsTwelve studies involving 15 interventions were included. Studies included 683 children with a neurodevelopmental disorder and 190 typically-developing children and diagnosed with either autism or ADHD. Within-group meta-analysis showed that the pooled intervention effects for friendship across all interventions were small to moderate (z = 2.761, p = 0.006, g = 0.485). The pooled intervention effect between intervention and comparison groups was not significant (z = 1.206, p = 0.400, g = 0.215).ConclusionFindings provide evidence that some individual interventions are effective in improving social functioning and fostering more meaningful friendships between children with neurodevelopmental disorders and their peers. Effective interventions involved educators, targeted child characteristics known to moderate peer functioning, actively involved peers, and incorporated techniques to facilitate positive peer perceptions and strategies to support peers. Future research should evaluate the effectiveness of friendship interventions for children with DLD, ID and SPCD, more comprehensively assess peer functioning, include child self-report measures of friendship, and longitudinally evaluate downstream effects on friendship.
A Mendelian randomization study on the causal association of circulating cytokines with colorectal cancer
Authors: Kong Youqian , Wang Xiaoyu , Xu Hongyun , Liu Shaoxuan , Qie Rui 
Published: December 2023

Background
Circulating cytokines have been associated with colorectal cancer (CRC). However, their causal correlation remains undetermined. This investigation uses genetic data to evaluate the mechanism that links circulating cytokines and CRC via Mendelian Randomization (MR).

Methods
A two-sample MR evaluation was carried out to investigate the mechanism associating circulating cytokines and CRC in individuals of European ancestry. The Genome-wide association studies statistics, which are publically accessible, were used. Eligible instrumental SNPs that were significantly related to the circulating cytokines were selected. Multiple MR analysis approaches were carried out, including Simple Mode, inverse variance weighted (IVW), MR-Egger, Weighted Mode, Weighted Median, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods.

Results
The evidence supporting the association of genetically predicted circulating levels with the increased risk of CRC was revealed; these included vascular endothelial growth factor (OR = 1.352, 95% CI: 1.019–1.315, P = 0.024), interleukin-12p70 (OR = 1.273, 95% CI: 1.133–1.430, P = 4.68×10−5), interleukin-13 (OR = 1.149, 95% CI: 1.012–1.299, P = 0.028), interleukin-10 (OR = 1.230, 95% CI: 1.013–1.493, P = 0.037), and interleukin-7 (OR = 1.191, 95% CI: 1.023–1.386 P = 0.024). Additionally, MR analysis negative causal association between macrophage colony stimulating factor and CRC (OR = 0.854, 95% CI: 0.764–0.955, P = 0.005). The data from Simple Mode, Weighted Median, MR-Egger, and Weighted Mode analyses were consistent with the IVW estimates. Furthermore, the sensitivity analysis indicated that the presence of no horizontal pleiotropy to bias the causal estimates.

Conclusion
This investigation identified a causal association between circulating cytokines levels risk of CRC and may provide a deeper understanding of the pathogenesis of CRC, as well as offer promising leads for the development of novel therapeutic targets for CRC.
ANÁLISE INTRAURBANA DA DINÂMICA ESPAÇO-TEMPORAL E FATORES ASSOCIADOS DOS CRIMES LETAIS E NÃO LETAIS CONTRA AS MULHERES EM SÃO LUÍS - MA
Authors: Pereira Izani Gonçalves dos Santos , Gonçalves Isaias Pereira da Silva , Rodrigues Zulimar Márita Ribeiro 
Published: December 2023

A violência contra a mulher é uma violação aos Direitos Humanos de graves consequências, portanto, deve ser monitorada através das políticas públicas de segurança e saúde e subsidiada por distintas áreas de conhecimento. Desta forma, o presente artigo analisou a dinâmica espaço-temporal dos crimes violentos contra as mulheres e fatores associados, ocorridos no período de 2014 a 2019, no município de São Luís (MA). Trata-se de uma pesquisa quanti-qualitativa com dados provenientes do “Programa de Avaliação e Monitoramento da Violência contra Mulheres na Grande São Luís”. Utilizou-se análise espacial para geração de produtos cartográficos além dos gráficos. Observou-se que os crimes analisados em São Luís se aglomeram, sobretudo, na região urbana do município, com intenso uso de arma de fogo. Concentrando-se em maior parte no período noturno, entre 18h e 24h, perpetrados, principalmente, contra mulheres de 19 a 40 anos de idade. Concluiu-se que as violências contra as mulheres em São Luís mostram-se preocupantes e alarmantes, necessitando de ampliação de políticas públicas para abranger todo o município, com eficiência e eficácia dos equipamentos públicos.
A CONSTRUÇÃO DE UMA SEQUÊNCIA DE ENSINO INVESTIGATIVO EM GEOGRAFIA SOB A ÓTICA DO ENSINO POR INVESTIGAÇÃO: UMA PROPOSTA POSSÍVEL
Authors: Fideles Geisa , Sedano Luciana 
Published: December 2023

O objetivo deste artigo é descrever e analisar uma Sequência de Ensino Investigativo (SEI) em Geografia, adotando a perspectiva do ensino por investigação como abordagem didática, buscando identificar indícios que a caracterizam como investigativa. Apresenta uma abordagem qualitativa, sendo fruto de uma pesquisa colaborativa. A SEI foi planejada juntamente com um professor de Geografia da Educação Básica do Ensino Médio, e está intitulada “Dinâmica demográfica e as relações socioespaciais.” Para planejá-la, realizamos oito encontros (reuniões online – via plataforma Google Meet). Para análise, consideramos as características do ensino por investigação proposta por Moura, Valois e Sedano (2019). Os resultados demonstram que a SEI possui caráter investigativo, atendendo os pressupostos do ensino por investigação. Apresenta uma proposição de como valorizar o conhecimento prévio do estudante, bem como a articulação entre as etapas e atividades propostas, de modo que o estudante possa, por meio do ensino investigativo, resolver problemas, levantar hipóteses, investigar e analisar os fenômenos estudados na aula. Sendo assim, esperamos que o trabalho sob a ótica dessa abordagem didática, por meio de SEI, encontre espaço nas aulas de Geografia, tornando-se um aliado potente para a promoção do ensino e aprendizagem.
Experiencias docentes que tensionan el código disciplinar androcéntrico de la historia
Authors: Rocha Milagros 
Published: December 2023

La enseñanza de la historia en Argentina, se ha caracterizado por su impronta memorística, nacionalista, eurocéntrica (De Amézola, 2008, 2020, Finocchio, 2009, González, 2014, 2016, 2017, 2018, 2019) y una fuerte presencia de masculinidades hegemónicas (Connell, 1997), en diferentes versiones, acorde al tiempo y espacio que se esté estudiando. La relevancia dada al sujeto varón, desde los “grandes hombres” y luego desde la historia “desde abajo”, se contrapone con la escasa visibilidad que se le ha dado a las mujeres, como actrices del pasado, así como a las disidencias. De esta manera se fue construyendo y enquistando un código disciplinar androcéntrico en la historia escolar. Desde este marco, y a partir de voces docentes, el presente trabajo analiza la historia enseñada, identificando cambios y continuidades, a fin de mapear los alcances y limitaciones de la historia de las mujeres y género.
Modalidades de relaciones causales que establecen estudiantes de primaria a partir de la lectura de un texto de contenido histórico
Authors: Torres Hernández Juan Guillermo 
Published: December 2023

Este trabajo tuvo por objetivo analizar las maneras en que alumnos de sexto grado de primaria reflexionaban sobre la causalidad histórica a partir del establecimiento de relaciones producto de una actividad de lectura. Se realizó un estudio cualitativo de corte exploratorio donde participaron nueve alumnos de sexto grado de primaria de Guanajuato, México. Se realizaron entrevistas individuales utilizando un protocolo de entrevista semiestructurada basado en ahondar en las interpretaciones causales sugeridas por los estudiantes. Los resultados mostraron seis modalidades de relación causal de las cuales cuatro contenían rasgos de temporalidad, otra contenía elementos semánticos y pragmáticos y una más se construía considerando la posición de los hechos en el texto. Se discuten los aspectos narrativos y discursivos de las relaciones causales que establecen los estudiantes, así como algunas reflexiones en torno a la aproximación de la historia a partir de la lectura de textos.
Strength characteristics and damage constitutive model of sandstone under hydro-mechanical coupling
Authors: Liu Qiang , Zhao Yanlin , Liao Jian , Tan Tao , Wang Xiaguang , Li Yang , Tan Zhe 
Published: December 2023

Abstract
To study the mechanical properties of saturated sandstone, experiments were conducted under hydro-mechanical coupling on saturated sandstone. A damage constitutive model was established to describe the response of saturated sandstone under pore pressure, and its validity was verified using the results of the triaxial tests. The results indicate that the peak strength (σ
p), effective peak strength (σ
p′), residual strength (σ
r), effective normal stress (σ
n′), effective shear strength (τ
n′), elasticity modulus (E), and rupture angle (θ) of sandstone are positively correlated with the confining pressure (σ
3) and negatively correlated with the pore pressure (P). Conversely, Poisson’s ratio (μ) exhibits an opposite relationship. The model parameters exhibit non-linear relationships with the confining pressure (σ
3), with the parameter m decreasing gradually as the confining pressure increases, and the parameter F
0 increasing with higher confining pressure (σ
3). Moreover, the pore pressure (P) and the confining pressure (σ
3) significantly affect the damage variables (D), with the stress value at the damage initiation point increasing with increasing confining pressure (σ
3), while the strain value at the damage initiation point decreasing with increasing pore pressure (P), indicating that pore pressure induces damage development in rocks.
“We’ve Forgotten Our Roots”: Bioweapons and Forms of Life inMass Effect’sSpeculative Future
Authors: Reid Eamon 
Published: December 2023

AbstractMany cultural artefacts explore the relationship between populations and politics, includingMass Effect, a role-playing videogame that both critiques and affirms liberal and conservative biopolitical tendencies. Of particular interest is the biopolitical dynamics of the Krogan lifeform. Due to population difficulties deriving from both naturalistic and cultural tendencies, they were targeted by a bioweapon – the genophage. The genophage drastically transformed how they comprehend their own form of life, as the bioweapon infected the Krogan with a plague-like genetic modification targeting their reproductive organs. The player in theMass Effecttrilogy can cure the genophage or not, and reasons are provided to contextualize both options. In this article, I argue that the genophage problematic can be interpreted as a reflection on the attempt to affect a form of life from the outside. I emphasize what Tristan Garica describes as we-expansion: thatMass Effectleaves open the question of the possibility of expanding our sense of we. ButMass Effectalso leaves open the question of we-contraction, in so doing it neither offers a utopian or dystopian political vision, but an agnostic one.
Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia
Authors: Gurieva Oksana Dmitryevna , Savelyeva Marina Ivanovna , Valiev Timur Tejmurazovich , Sozaeva Zhannet Alimovna , Kondratenko Svetlana Nikolaevna , Ilyin Mikhail Vitalyevich 
Published: December 2023

Abstract

Objectives
To evaluate the role of ABCB1 (C3435T rs1045642, rs1128503, rs2032582, rs4148738), SLCO1B1 T521C rs4149056 genetic polymorphisms in the development of major types of methotrexate (MTX) toxicities and the occurrence of a terminal event (death, relapse) in pediatric АLL.

Methods
The study included 124 patients diagnosed with pediatric ALL. All patients treated according to the protocols of the German BFM group (2002/2009) with high-dose (1,000, 2,000 and 5,000 mg/m2) methotrexate. MTX-related toxicities, including hematologic, hepatic and renal, were evaluated according to the common terminology criteria for adverse events version 5.0 (CTCAE v.5.0). Real-time PCR method was used to investigate polymorphisms of ABCB1 and SLCO1B1 genes. The study material was peripheral blood.

Results
A competitive analysis demonstrated significant relationships between MTX ADRs. The results of the study support the existence of relationships between some ADRs and MTX kinetics. An associative analysis showed association with the development of AEs to methotrexate indicating their clinical significance from different genetic polymorphisms protein-transporters. The available results confirm the associations of the studied genes with the increased risk of high doses MTX toxic ADRs and terminal events.

Conclusions
Complementing the existing criteria for pediatric ALL risk groups with pharmacogenetic indicators will allow further individualization of therapy.
Investigating optimal spacing schedules for incidental acquisition of L2 collocations
Authors: Macis Marijana , Alharbi Rezan , Sonbul Suhad 
Published: December 2023

Abstract
Research investigating lag effects in second language (L2) collocation learning is very limited. To date, no intervention study has examined the relationship between intersession intervals (ISIs) and retention intervals (RIs) in relation to incidental acquisition of collocations. To fill this gap, the current study collected data from two groups of students in Saudi Arabia (Experiment 1, n = 73; Experiment 2, n = 69), using a pretest-treatment-delayed posttest design. The participants learned 25 incongruent adjective-noun collocations incidentally during five reading sessions at either a 3.5-day ISI (Experiment 1) or a 7-day ISI (Experiment 2). Two control groups received no treatment. Learning rates were assessed at the form recall and meaning recall levels of sensitivity following an RI of 14 days in Experiment 1 and an RI of 28 days in Experiment 2. Results show that both spacing schedules were equally effective for the incidental acquisition of collocations.
Presumptions of Law Concerning Causality in Environmental Cases: Towards Collective Presumptions of Fact?
Authors: Van Eekert Simon 
Published: December 2023

Abstract
Presumptions of law are an appealing concept to remedy situations of causal uncertainty. In many pieces of EU legislation in various areas such as competition law, AI law and environmental law, presumptions are presented as a solution for plaintiffs that encounter problems regarding causal uncertainty in their compensation claims. Oftentimes, however, insufficient attention is paid to the possible risks of over- and under-compensation, the available alternatives and the functionality of these presumptions. In this article, I argue that a presumption of law fulfils two functions. First, this paper aims to address situations of evidentiary deficiency (individual goal). Second, it aims to facilitate the procedural road to compensation in cases of mass harm (collective goal). A comparative analysis of Belgian, Dutch and French law reveals that there are many ways to shape a presumption and its consequences. In conclusion, I argue that presumptions should always be tailored to a certain case and should attempt to reconcile the collective goal with the individual goal. To that end, policy-makers should aim to create collective presumptions of fact, based on the statistical evidence in a certain mass harm case, as opposed to presumptions of law.
SAMNA: accurate alignment of multiple biological networks based on simulated annealing
Authors: Chen Jing , Wang Zixiang , Huang Jia 
Published: December 2023

Abstract
Proteins are important parts of the biological structures and encode a lot of biological information. Protein–protein interaction network alignment is a model for analyzing proteins that helps discover conserved functions between organisms and predict unknown functions. In particular, multi-network alignment aims at finding the mapping relationship among multiple network nodes, so as to transfer the knowledge across species. However, with the increasing complexity of PPI networks, how to perform network alignment more accurately and efficiently is a new challenge. This paper proposes a new global network alignment algorithm called Simulated Annealing Multiple Network Alignment (SAMNA), using both network topology and sequence homology information. To generate the alignment, SAMNA first generates cross-network candidate clusters by a clustering algorithm on a k-partite similarity graph constructed with sequence similarity information, and then selects candidate cluster nodes as alignment results and optimizes them using an improved simulated annealing algorithm. Finally, the SAMNA algorithm was experimented on synthetic and real-world network datasets, and the results showed that SAMNA outperformed the state-of-the-art algorithm in biological performance.
Onsager-Casimir reciprocal relations as a consequence of the equivalence between irreversibility and dissipation
Authors: Klika Václav , Bréchet Sylvain D. 
Published: December 2023

Abstract
The equivalence between irreversibility and dissipation entails that the Onsager reciprocal relations hold unconditionally, requiring the part of the phenomenological matrix describing dissipative phenomena to be symmetric. The antisymmetric part of the phenomenological matrix corresponds to the Casimir’s variant of the reciprocal relations and describes reversible phenomena. Further, we discuss the relationship of the reversibility and entropy production, including the role of the level of description, and we use the chemotaxis as an illustrative example.
Green synthesis and characterization of ginger-extract-based oxali-palladium nanoparticles for colorectal cancer: Downregulation of REG4 and apoptosis induction
Authors: Cherik Ilnaz Tork , Divsalar Adeleh , Angaji Seyed Abdolhamid , Rasouli Milad , Bekeschus Sander , Movahedi Ali Akbar Moosavi , Moghadam Mahboube Eslami , Ghalandari Behafarid , Ding Xianting 
Published: December 2023

Abstract
Colorectal cancer (CRC) continues to pose a significant challenge to healthcare systems, despite considerable advancements in the fields of medicine and pharmaceuticals. Palladium complexes, considered potential alternatives to platinum-based drugs for treating CRC, are being explored. Additionally, green chemistry, which enables the safe, reproducible, and environmentally friendly synthesis of drugs from natural sources, presents a promising avenue for oncological therapy. This study delves into the synthesis, characterization, and physicochemical properties of oxali-palladium nanoparticles (OxPd NPs) as a novel treatment for CRC using a green synthesis approach. Ginger extract, renowned for its antioxidant and anticancer properties, serves as the source material. The obtained results demonstrate that the synthesis and encapsulation of nanoparticles using ginger extract were conducted with an efficiency of 98%. The nanoparticles exhibited a size of approximately 30 nm and displayed a high level of stability. OxPd NPs were more lethal than ginger extract and free oxaliplatin, and this lethality was attributable to the elevated apoptosis rate. Furthermore, the addition of OxPd NPs to CRC cells resulted in significant alterations in the expression of two cancer-related genes, namely catalase and REG4. The pronounced lethal effect on the CRC cell line and the resulting modulation of gene expression highlight OxPd NPs as promising candidates for further investigation as potential drugs in the treatment of CRC.