bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supervised on-site dosing in injectable opioid agonist treatment-considering the patient perspective. Findings from a cross-sectional interview study in two German cities
Authors: Friedmann Zoe , Kinkel Hans-Tilmann , Kühner Claudia , Zsolnai Andreas , Mick Inge , Binder Annette 
Published: November 2023

AbstractBackgroundInjectable opioid agonist treatment (iOAT) is an effective option to support people living with opioid use disorder (OUD) who have not sufficiently benefitted from oral OAT. However, iOAT has been criticised based on theoretical and practical grounds for its dosing policies: Current regulations demand supervised, on-site application and require patients to frequently visit their treatment facility. The current study aims to investigate how patients experience on-site application and derive strategies to enhance the acceptability and effectiveness of iOAT-delivery.MethodsThis article is based on semi-structured interviews with 27 individuals currently or previously in iOAT in two German outpatient iOAT-clinics. We undertook an inductive qualitative content analysis, which included blinded, independent coding and the analysis of individual cases.ResultsComments regarding on-site application and daily visits to the clinic were grouped intopositive and negative aspects,iOAT as the best alternative option, facilitators of daily visits, andsuggestions for improvement. Positive aspects took the factors stability and social support in regard. Negative aspects ranged from general inconveniences to major impediments to individuals' daily lives and towards achieving psychosocial goals. Participants reported rigorous adherence to iOAT's treatment regime, often due to a perceived lack of alternative options. Meeting iOAT's demands was eased by the patients’ coping-strategies and through facilitating measures implemented by iOAT-clinics. Despite acknowledgement of the potential detriments from easing regulations, take-home arrangements were frequently suggested by participants to improve iOAT.ConclusionsBeing required to attend the clinic for supervised iOAT-application is not experienced uniformly. While clinics can support their patients to cope with strict regulations, alternative approaches to iOAT-application should be considered to accommodate patients' individual needs. Examples from other treatment modalities (e.g., remote supervision and delivery services) might aid to reconcile individualisation while providing adequate safety measures and improve iOAT in the long term.
The mechanisms of nerve injury caused by viral infection in the occurrence of gastrointestinal motility disorder-related diseases
Authors: Li Yaqian , Chen Qiuyu , Wang Liwei , Chen Xin , Wang Bangmao , Zhong Weilong 
Published: November 2023

AbstractGastrointestinal motility refers to the peristalsis and contractility of gastrointestinal muscles, including the force and frequency of gastrointestinal muscle contraction. Gastrointestinal motility maintains the normal digestive function of the human body and is a critical component of the physiological function of the digestive tract. At present, gastrointestinal motility disorder-related diseases are gradually affecting human production and life. In recent years, it has been consistently reported that the enteric nervous system has a coordinating and controlling role in gastrointestinal motility. Motility disorders are closely related to functional or anatomical changes in the gastrointestinal nervous system. At the same time, some viral infections, such as herpes simplex virus and varicella-zoster virus infections, can cause damage to the gastrointestinal nervous system. Therefore, this paper describes the mechanisms of viral infection in the gastrointestinal nervous system and the associated clinical manifestations. Studies have indicated that the means by which viruses can cause the infection of the enteric nervous system are various, including retrograde transport, hematogenous transmission and centrifugal transmission from the central nervous system. When viruses infect the enteric nervous system, they can cause clinical symptoms, such as abdominal pain, abdominal distension, early satiation, belching, diarrhea, and constipation, by recruiting macrophages, lymphocytes and neutrophils and regulating intestinal microbes. The findings of several case‒control studies suggest that viruses are the cause of some gastrointestinal motility disorders. It is concluded that one of the causes of gastrointestinal motility disorders is viral infection of the enteric nervous system. In such disorders, the relationships between viruses and nerves remain to be studied more deeply. Further studies are necessary to evaluate whether prophylactic antiviral therapy is feasible in gastrointestinal motility disorders.
A practical guide to in situ and ex situ characterisation of arabinogalactan proteins (AGPs) in fruits
Authors: Kutyrieva-Nowak Nataliia , Leszczuk Agata , Zdunek Artur 
Published: November 2023

Abstract
Background
Arabinogalactan proteins (AGPs) are plant cell components found in the extracellular matrix that play crucial roles in fruit growth and development. AGPs demonstrate structural diversity due to the presence of a protein domain and an expanded carbohydrate moiety. Considering their molecular structure, the modification of glycosylation is a primary factor contributing to the functional variety of AGPs.

Main body
Immunocytochemical methods are used for qualitative and quantitative analyses of AGPs in fruit tissues. These include in situ techniques such as immunofluorescence and immunogold labelling for visualising AGP distribution at different cellular levels and ex situ methods such as Western blotting and enzyme-linked immunoenzymatic assays (ELISA) for molecular characterisation and quantitative detection of isolated AGPs. The presented techniques were modified by considering the structure of AGPs and the changes that occur in fruit tissues during the development and ripening processes. These methods are based on antibodies that recognise carbohydrate chains, which are the only commercially available highly AGP-specific tools. These probes recognise AGP epitopes and identify structural modifications and changes in spatio-temporal distribution, shedding light on their functions in fruit.

Conclusion
This paper provides a concise overview of AGP research methods, emphasising their use in fruit tissue analysis and demonstrating the accessibility gaps in other tools used in such research (e.g. antibodies against protein moieties). It underscores fruit tissue as a valuable source of AGPs and emphasises the potential for future research to understand of AGP synthesis, degradation, and their roles in various physiological processes. Moreover, the application of advanced probes for AGP visualisation is a milestone in obtaining more detailed insights into the localisation and function of these proteins within fruit.
Variability of temperature measurements recorded by a wearable device by biological sex
Authors: Bruce Lauryn Keeler , Kasl Patrick , Soltani Severine , Viswanath Varun K. , Hartogensis Wendy , Dilchert Stephan , Hecht Frederick M. , Chowdhary Anoushka , Anglo Claudine , Pandya Leena , Dasgupta Subhasis , Altintas Ilkay , Gupta Amarnath , Mason Ashley E. , Smarr Benjamin L. 
Published: November 2023

Abstract
Background
Females have been historically excluded from biomedical research due in part to the documented presumption that results with male subjects will generalize effectively to females. This has been justified in part by the assumption that ovarian rhythms will increase the overall variance of pooled random samples. But not all variance in samples is random. Human biometrics are continuously changing in response to stimuli and biological rhythms; single measurements taken sporadically do not easily support exploration of variance across time scales. Recently we reported that in mice, core body temperature measured longitudinally shows higher variance in males than cycling females, both within and across individuals at multiple time scales.

Methods
Here, we explore longitudinal human distal body temperature, measured by a wearable sensor device (Oura Ring), for 6 months in females and males ranging in age from 20 to 79 years. In this study, we did not limit the comparisons to female versus male, but instead we developed a method for categorizing individuals as cyclic or acyclic depending on the presence of a roughly monthly pattern to their nightly temperature. We then compared structure and variance across time scales using multiple standard instruments.

Results
Sex differences exist as expected, but across multiple statistical comparisons and timescales, there was no one group that consistently exceeded the others in variance. When variability was assessed across time, females, whether or not their temperature contained monthly cycles, did not significantly differ from males both on daily and monthly time scales.

Conclusions
These findings contradict the viewpoint that human females are too variable across menstrual cycles to include in biomedical research. Longitudinal temperature of females does not accumulate greater measurement error over time than do males and the majority of unexplained variance is within sex category, not between them.
Using the Elixhauser risk adjustment model to predict outcomes among patients hospitalized in internal medicine at a large, tertiary-care hospital in Israel
Authors: Katz David E. , Leibner Gideon , Esayag Yaakov , Kaufman Nechama , Brammli-Greenberg Shuli , Rose Adam J. 
Published: November 2023

Abstract
Background
In Israel, internal medicine admissions are currently reimbursed without accounting for patient complexity. This is at odds with most other developed countries and has the potential to lead to market distortions such as avoiding sicker patients. Our objective was to apply a well-known, freely available risk adjustment model, the Elixhauser model, to predict relevant outcomes among patients hospitalized on the internal medicine service of a large, Israeli tertiary-care hospital.

Methods
We used data from the Shaare Zedek Medical Center, a large tertiary referral hospital in Jerusalem. The study included 55,946 hospitalizations between 01.01.2016 and 31.12.2019. We modeled four patient outcomes: in-hospital mortality, escalation of care (intensive care unit (ICU) transfer, mechanical ventilation, daytime bi-level positive pressure ventilation, or vasopressors), 30-day readmission, and length of stay (LOS). We log-transformed LOS to address right skew. As is usual with the Elixhauser model, we identified 29 comorbid conditions using international classification of diseases codes, clinical modification, version 9. We derived and validated the coefficients for these 29 variables using split-sample derivation and validation. We checked model fit using c-statistics and R2, and model calibration using a Hosmer–Lemeshow test.

Results
The Elixhauser model achieved acceptable prediction of the three binary outcomes, with c-statistics of 0.712, 0.681, and 0.605 to predict in-hospital mortality, escalation of care, and 30-day readmission respectively. The c-statistic did not decrease in the validation set (0.707, 0.687, and 0.603, respectively), suggesting that the models are not overfitted. The model to predict log length of stay achieved an R2 of 0.102 in the derivation set and 0.101 in the validation set. The Hosmer–Lemeshow test did not suggest issues with model calibration.

Conclusion
We demonstrated that a freely-available risk adjustment model can achieve acceptable prediction of important clinical outcomes in a dataset of patients admitted to a large, Israeli tertiary-care hospital. This model could potentially be used as a basis for differential payment by patient complexity.
Business resilience and growth strategy transformation post crisis
Authors: Bachtiar Nia Kurniati , Setiawan Agus , Prastyan Galih Adi , Kijkasiwat Ploypailin 
Published: November 2023

AbstractThe recent crisis world experienced (Covid-19) undoubtedly changed many aspects of business, such as operations, growth, sales, etc. A business needs capability and strategy to survive, and this paper considers resilience and growth suitable for encountering a crisis. Following that, this paper argues that resilience not only results from a crisis, as mentioned in previous studies but is a process. We also argue that growth strategy and its stages differ between regular times and times of crisis. This paper aims to elaborate on changes in business resilience and growth strategies as a reaction to a crisis by building line-by-line coding, patterns, and themes. This study develops a conceptual model for forming business sustainability after a crisis with resilience and growth as pillars. This qualitative study used snowball sampling with 13 case studies and conducted semi-structured interviews, Focus Group Discussion (FGD), and observation with dependability, credibility, confirmability, and transferability as the triangulation processes. This inductive study demonstrates resilience and growth steps that can assist entrepreneurs in avoiding misleading strategies. The findings also indicated that digital imperatives could hasten both processes to attain sustainability. This paper draws on organizational resilience theory to discuss the theoretical implications of this research. This study discovers three main stages in the resilience process: resilience awareness, adaptation, and action, and growth stages in crisis time, namely no growth, growth support, growth force, and sustainable growth. On a practical level, the proposed model can also assist entrepreneurs in dealing with a crisis regarding what to do and understanding their conditions. This study contributes to the ongoing debate on how to respond to crisis and provides complete stages in resilience response and growth strategies for a business. For future research, this paper recommends a longitudinal study to understand and analyse the implementation and effectiveness of the models.
Psychological distress, anxiety, depression, stress level, and coping style in HIV-pregnant women in Mexico
Authors: Meza-Rodríguez María del Pilar , Farfan-Labonne Blanca , Avila-García Miroslava , Figueroa-Damian Ricardo , Plazola-Camacho Noemí , Pellón-Díaz Gabriela , Ríos-Flores Braulio Alfonso , Olivas-Peña Efraín , Leff-Gelman Phillipe , Camacho-Arroyo Ignacio 
Published: November 2023

AbstractPurposeTo evaluate the presence of psychological distress (PD) and its association with the mental health and coping styles of pregnant women living with HIV (PWLWH).MethodAn observational, cross-sectional descriptive study was performed. Seventy-three PWLWH were included. Patients responded to a psychometric battery for PD, depression, anxiety, stress, and coping style evaluation. The scales used in the study were: Goldberg’s 30-item General Health Questionnaire (GHQ-30), State-Trait Anxiety Inventory (STAI), Zung Depression Self-Measurement Scale (ZDS), Nowack Stress Profile, Lazarus and Folkman’s Coping Styles Questionnaire.ResultsPD was observed in 31.5% of the participants. PD-positive patients showed a higher probability of presenting traits of depression and anxiety and medium/high stress levels. Besides, they preferentially used emotion-focused coping styles.ConclusionPD is associated with a higher probability of presenting anxiety and depression in PWLWH. Emotion-focused coping style could be a factor in decision-making associated with risk behaviors in PWLWH.
IgG4-related mastitis characterized by skin thickening of the breast: a case report
Authors: Itakura Moe , Horimoto Yoshiya , Ishizuka Yumiko , Onagi Hiroko , Hayashi Takuo , Kawamoto Toshio , Watanabe Junichiro , Iijima Kotaro 
Published: November 2023

Abstract
Background
IgG4-related diseases are characterized by marked infiltration and IgG4-positive plasma cells and fibrosis, and involve multiple organs. However, IgG4-related mastitis is rare. We report a case of mastitis associated with IgG4-related disease.

Case presentation
A 78-year-old woman visited our hospital with a complaint of multiple subcutaneous nodules. A biopsy of a dorsal subcutaneous mass was performed but did not yield a definitive diagnosis. However, blood tests showed a high level of IgG4, thus she was referred to the department of collagen disease for further examination. Computed tomography (CT) showed a thickening of the skin of the right breast, and the patient was referred to our department. On physical examination, a large area of thickened skin was observed in the right breast without inflammatory breast cancer-like redness, and no mass was palpable. A needle biopsy was performed on an indistinct hypoechoic area in the breast, and she was diagnosed with mastitis associated with IgG4-related disease. Systemic steroid therapy was then administered and the symptoms of multiple skin nodules and mastitis improved.

Conclusions
We reached the diagnosis based on a biopsy of the mammary gland enabling the patient to begin treatment for IgG4-related disease. This case was characterized by breast skin thickening, which is different from inflammatory breast cancer.
Resistant hypertension: consensus document from the Korean society of hypertension
Authors: Park Sungha , Shin Jinho , Ihm Sang Hyun , Kim Kwang-il , Kim Hack-Lyoung , Kim Hyeon Chang , Lee Eun Mi , Lee Jang Hoon , Ahn Shin Young , Cho Eun Joo , Kim Ju Han , Kang Hee-Taik , Lee Hae-Young , Lee Sunki , Kim Woohyeun , Park Jong-Moo 
Published: November 2023

AbstractAlthough reports vary, the prevalence of true resistant hypertension and apparent treatment-resistant hypertension (aTRH) has been reported to be 10.3% and 14.7%, respectively. As there is a rapid increase in the prevalence of obesity, chronic kidney disease, and diabetes mellitus, factors that are associated with resistant hypertension, the prevalence of resistant hypertension is expected to rise as well. Frequently, patients with aTRH have pseudoresistant hypertension [aTRH due to white-coat uncontrolled hypertension (WUCH), drug underdosing, poor adherence, and inaccurate office blood pressure (BP) measurements]. As the prevalence of WUCH is high among patients with aTRH, the use of out-of-office BP measurements, both ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM), is essential to exclude WUCH. Non-adherence is especially problematic, and methods to assess adherence remain limited and often not clinically feasible. Therefore, the use of HBPM and higher utilization of single-pill fixed-dose combination treatments should be emphasized to improve drug adherence. In addition, primary aldosteronism and symptomatic obstructive sleep apnea are quite common in patients with hypertension and more so in patients with resistant hypertension. Screening for these diseases is essential, as the treatment of these secondary causes may help control BP in patients who are otherwise difficult to treat. Finally, a proper drug regimen combined with lifestyle modifications is essential to control BP in these patients.
Graphical Abstract
The globalization of bibimbap: focusing on the diversity of modernization of bibimbap
Authors: Mun Eun-Gyung , Lee Young-Eun , Cha Youn-Soo 
Published: November 2023

AbstractKorea is developing a food culture based on various vegetation. Bibimbap is a one-dish meal that harmonizes the characteristics of Korean food. Bibimbap is made by placing seasoned meat, vegetables (namul), vegetable oil (sesame and perilla), and jang (gochujang, ganjang, or doenjang) on top of warm rice. Since ancient times, bibimbap has been served on a table of various classes, from the royal court to the common people, and it has the convenience of meals and the spirit of community. Therefore, bibimbap is for many people to gather an eat deliciously. The famous bibimbap regions in Korea include Jeonju, Jinju, and Andong, and each has its characteristics. Depending on the serving style, they can be divided into brass or stone pot bowls. Depending on the main ingredients, it is also divided according to vegetables, grains, meat, and seafood. Additionally, restaurants specializing in bibimbap are prevalent in Korea, and there are many commercially launched products such as retort food, in-flight meal, and ingredients for bibimbap. Bibimbap is responsible for the Korean table by combining various fields from gourmet to homemade meals. As can be seen from this point, bibimbap has the characteristics of a customized meal as the characteristic of consumers being able to choose food ingredients are remarkable. Bibimbap is a food that can be applied without time, space, and individual restrictions by combining various foods in one bowl to balance and harmonize with each other.
Effect of endoscopic sinus surgery on quality of life among the patients of chronic rhinosinusitis with nasal polyposis
Authors: Sellami Mustapha , Abdi Samira , Boudjenah Farid 
Published: November 2023

Abstract
Background
Quality of life (QoL) tests are usually used to assess the response to different therapies. They are the tools that best reflect the patients’ complaints, the severity of their pathology, and the post-therapeutic gains.
The aim of the present study is to assess the effect of endoscopic sinus surgery (ESS) on quality of life (QoL) among the patients of chronic rhinosinusitis with nasal polyposis (CRSwNP), using the Sino-Nasal Outcome Test 22 items (SNOT-22).

Methods
This is a prospective, descriptive, and monocentric study involving all the patients who underwent surgery for CRS with nasal polyposis at Bejaia University Hospital over a period of 36 months, from January 1st, 2017, to December 31st, 2019.
A SNOT-22 test was completed item by item with our patients, before any surgery, and after endoscopic sinus surgery at 1 month, 3 months, 6 months, 9 months, and 12 months.

Results
Sixty-five patients, having undergone ESS for CRS with nasal polyposis, were followed during a period 12 months. The average age of our patients was 42.06 ± 12.47 years, with 41.5% females and 58.5% males.
Clinical examination showed that impairment was bilateral in 100% of our patients, while the nasal endoscopy showed that the polyps reached stage III in 87.7% of the cases on the right and 80% on the left. The mean Lund-Mackay CT score was 18.71 ± 4.77/24.
All of the patients were treated with local and general short courses of corticosteroid therapy before ESS was indicated.
Our results showed improvement in the QoL of our patients and maintenance of this gain after surgery. The average total SNOT-22 score for them was 49.41 ± 17.12 pre-operatively; post-operatively it was 12.14 ± 10.22 after 1 month; 10.31 ± 8.17 after 3 months; 9.35 ± 8.93 after 6 months; 12.21 ± 15.45 after 9 months and 12.63 ± 16.23 after 12 months.

Conclusion
ESS is the gold standard in the treatment of chronic rhinosinusitis with nasal polyposis after failure of medical therapy.
The use of SNOT-22 test enabled us to confirm that whatever the surgical procedure applied, the QoL improves after surgery.