bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two at once: simultaneous increased production of astaxanthin and mycosporines in a single Batch culture using a Phaffia rhodozyma mutant strain
Authors: Moliné Martín , Libkind Diego , Broock María Rosa van 
Published: October 2023

Abstract
Phaffia rhodozyma is a basidiomycetous yeast characterized by its production of the carotenoid pigment astaxanthin, which holds high commercial value for its significance in aquaculture, cosmetics and as nutraceutics, and the UV-B-absorbing compound mycosporine-glutaminol-glucoside (MGG), which is of great biotechnological relevance for its incorporation into natural sunscreens. However, the industrial exploitation has been limited to the production of astaxanthin in small quantities. On the other hand, the accumulation of MGG in P. rhodozyma was recently reported and could add value to the simultaneous production of both metabolites. In this work, we obtain a mutant strain that overproduces both compounds, furthermore we determined how the accumulation of each is affected by the carbon-to-nitrogen ratio and six biotic and abiotic factors. The mutant obtained produces 159% more astaxanthin and 220% more MGG than the parental strain. Furthermore, we establish that the carotenoids accumulate during the exponential growth phase while MGG accumulates during the stationary phase. The carbon-to-nitrogen ratio affects each metabolite differently, high ratios favoring carotenoid accumulation while low ratios favoring MGG accumulation. Finally, the accumulation of both metabolites is stimulated only by photosynthetically active radiation and low concentrations of hydrogen peroxide. The mutant strain obtained is the first hyper-productive mutant capable of accumulating high concentrations of MGG and astaxanthin described to date. The characterization of how both compounds accumulate during growth and the factors that stimulate their accumulation, are the first steps toward the future commercial exploitation of strains for the simultaneous production of two biotechnologically important metabolites.
Siglec-15 expression in diffuse glioma and its correlation with MRI morphologic features and ADC
Authors: Chen Quan , Wang Chunhua , Geng Yingqian , Zheng Wanyi , Shi Yuting , Xiao Huinan , Sun Yifan , Hu Xiaomei , Jiang Rifeng , Wu Zhenxing 
Published: October 2023

Abstract
Objective: To investigate the expression of sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) in diffuse glioma and its correlation with magnetic resonance imaging (MRI) features for glioma patients.
Materials and Methods: This retrospective study included 57 glioma patients. Morphological MRI features including the largest tumor diameter, enhancement category, location, calcification, cysts, and hemorrhage were visually rated. Apparent diffusion coefficient (ADC) values were calculated in tumor region. The difference of MRI morphologic features and ADC were compared between patients with positive and negative Siglec-15 expression. Receiver operating characteristic (ROC) curves were further constructed to assess the diagnostic performance.
Results: Siglec-15 was not expressed in glioma cells, but in immunocytes such as macrophages in the peritumoral area. Positive Siglec-15 expression was observed in 35.09% (20/57) of patients, and higher in IDH1-mutant gliomas and lower-grade gliomas. The tumor diameter was significantly smaller in patients with positive Siglec-15 expression than in those with negative expression for all glioma patients (p=0.017) and for patients with mutant IDH1 glioma (p=0.020). Moreover, ADC values of the tumor were significantly higher in patients with positive Siglec-15 expression than in those with negative expression for all glioma patients (p=0.027). The areas under curve (AUCs) of the diameter and ADC were 0.702 and 0.686, respectively. A combination of these two parameters generated an improved AUC of 0.762, a sensitivity of 73.68%, and a specificity of 71.87%.
Conclusions: Siglec-15 was not expressed in glioma cells, but in immunocytes such as macrophages in the peritumoral area, with a positive rate of 35.09%. Positive Siglec-15 expression in diffuse glioma was correlated with smaller tumor size and higher ADC values.
Session-based Recommendation Model of Graph Neural Network with Attention Mechanism
Authors: Jimenez Tlaloc , Norton John , Salazar Ixchel , Morales Quetzal 
Published: October 2023

Abstract
People have moved from the era of data poverty to the era of information sharing and the volume of data has exploded. Recommendation systems are based on the user's characteristics and generated behavioral data, and characterize the user's preferences through the user's ratings, comments, votes, and other behaviors; however, in many scenarios, the user's aforementioned information is not available due to security requirements. In recent years, most of the studies applied recurrent neural networks to session-based recommender systems with good results. However, these algorithms still have the following problems: 1. Modeling unidirectional transitions between consecutive items using only the sequence of user clicks. They ignore other items in the session, i.e., they ignore the complex transitions between distant items. 2. Ignoring information about the time an item is viewed. It is widely recognized that users tend to spend more time on items that interest them. In this paper, we propose a session-based recommendation model based on graph neural networks. The embedding information of items and item categories is obtained by a graph neural network. Because different features have different levels of importance in the prediction, the module uses an attention mechanism to fuse the information and get a final representation of the session that predicts the next item to interact with. Finally, the recurrent neural network (RNN) is used to obtain the session timing information for recommendation.
An Analysis of Bilingual Text in Pakistani Advertisements: A Sociolinguistics Study
Authors: Ghulam Kishwar , Nusrat Muhammad 
Published: October 2023

Abstract
This study is based on sociolinguistic aspects of advertisements, and these advertisements contain bilingual text and diversity of human life governed through advertisements in which all cultural life portrayed by advertisers and designers of these companies design the advertisements according to regional culture as this research based on the bilingual text on Pakistani advertisements and according to Pakistani culture the most common used language is URDU which analyzed in this research along with commonly used international language ENGLISH. This study revealed that linguistics and semiotics on advertisements according to Pakistani culture, and this research is based on the qualitative design, which explored cross-cultural aspects based on Roland Barthes’s theory. These ads become a source of target audiences of that culture, and bilingual text on advertisements became the source of the conversation, thus promoting products and constructing identity in this diversity occurred through bilingual advertisements like Banks, companies’ identity, beauty products, food and clothing brands, medicine companies remained the research study.
Association between microbiome and psoriasis vulgaris and arthropathic psoriasis: a bidirectional two-sample Mendelian randomization study
Authors: Zhang Jin , Xiang Yang , Shen Yingjie , Chen Jiqiu , Liu Lei , Liu Qingsong , Jin Jian , Zhu Shihui 
Published: October 2023

Abstract
Background:
Research has found that a certain link between gut microbiota(GM) and arthropathic psoriasis(PsA) and psoriasis vulgaris(PV). However, the association between GM and PsA and PV has yield conflicting results due to the influence of confounding factors. GM may increase the risk of PsA and PV through the gut-skin axis.
Methods:
We used a two-sample Mendelian randomization (MR) study to explore the relationship between GM and PsA and PV, using genetic variation from published genome-wide association studies as an instrumental variable. Reverse variance weighting, maximum likelihood, MR Egger, weighted median, weighted model, MR-PRESSO, and cML MA were used to examine the causal relationship between GM and PsA and PV. Several sensitivity analyses were also performed to ensure the accuracy of the re-sults Cochran's Q statistics are used to quantify the heterogeneity of Instrumental variables estimation.
Results:
A higher genetically predicted abundance Odoribacter was associated with a reduced risk of psoriasis. While a higher genetically predicted abundance of Ruminiclostridium5 was associated with an increased risk of psoriasis. The genetically predicted relative abundance of Verrucomicrobiae, Verrucomicrobiaceae, Akkermansia, Verrucomicrobiales were positively associated with arthropathic psoriasis. A higher genetically predicted abundance of Rikenellaceae served as protective factors for arthropathic psoriasis. Specifically, a higher genetically predicted Atinomycetaceae, Eubacterium fissicatena group, Lactococcus, and Actinomycetales were associated with a higher risk of psoriasis vulgaris. In contrast, higher genetically predicted Odoribacter was a lower risk of psoriasis vulgaris. No significant heterogeneity or level pleiotropy of Instrumental variables estimation was found.
Conclusion:
This MR study offer novel perspectives regarding the prevention, advancement, and therapy of psoriasis by concentrating on specific bacterial groups. Additional research is required to specify the exact mechanism relating the association between gut microbiota and psoriasis along with its classifications.
The Association between Blood Glucose Levels and Lipids in the General Adult Population: Results from NHANES (2005–2016)
Authors: Yang Chenghao , Zhang Lingxiao , Gao Junqing , Liu Zongjun 
Published: October 2023

Abstract
OBJECTIVE: Although abnormal lipid metabolism is one of the major risk factors for diabetes, the correlation between lipids and glucose is rarely discussed in the general population. The differences in lipid-glucose correlations across gender and ethnicity have been even more rarely studied. We examined the association between fasting blood glucose (FBG) and lipids, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apolipoprotein B (ApoB), using 6,093 participants aged 20 years or older from the National Health and Nutrition Examination Survey (NHANES).
METHODS: Analyses were performed using multiple logistic regression and generalised additive models.
RESULTS: When other confounders were considered, we found that fasting glucose was positively correlated with triglycerides and negatively correlated with HDL-C, whereas total cholesterol, LDL-C cholesterol, and fasting glucose were related to each other in a U-curve fashion, with inflection points of 5.17 mmol/L and 2.3 mmol/L, respectively.This relationship persisted in subgroups of different sexes and races. A positive correlation was found between fasting glucose and ApoB, but subgroup analyses revealed that this relationship was not correlated across gender and race.
CONCLUSION: In the general population, fasting blood glucose levels were positively correlated with TG, negatively correlated with HDL-C, and U-shaped with total cholesterol and LDL-C. The likelihood of developing diabetes was 40% higher when LDL-C was greater than 2.3 mmol/L than in patients with LDL-C less than 2.3 mmol/L.
Exploration: 16 Shells and Magic Numbers
Authors: Lin Jingfeng 
Published: October 2023

Abstract
This paper explores the regularity of nucleon numbers and magic numbers within known nuclides, presenting a hierarchical arrangement mechanism that suggests a shell structure spanning from 1 to 16. This proposed structure unifies nucleon distribution patterns in specific nuclides associated with magic numbers. Additionally, we discuss elemental atomic weight inversions as supporting evidence for the nucleon arrangement pattern. These arrangements are interpreted as eigenstates of nucleon probability density. Furthermore, the study introduces a three-dimensional structural extension in the form of a toroidal helix model. Nevertheless, grasping the full complexity of this intriguing model remains a formidable challenge.
A Retrospective Cohort to Access the Accuracy of Agitated Saline Bubble–Enhanced Ultrasound to Visualize Appropriated Position of Hemodialysis Catheter: Does Catheter Venous Site Matter?
Authors: Barbosa Géssica Sabrine Braga , Smolentzov Igor , Ribeiro Rayra Gomes , Filho Marcelo Paes Menezes , Cortes Daniela del Pilar via Reque , Botter Denise Aparecida , Gutierrez Gabriel Monteiro , Sandoval Mônica Carneiro , Rodrigues Camila Eleutério 
Published: October 2023

Abstract
Background
The non-tunnelled hemodialysis catheter (HDC) is commonly used to start renal replacement therapy in hospitalised patients, especially in acute kidney injury. Malposition of HDC is associated with delayed therapy and inadequate dialysis. Agitated saline bubble-enhanced ultrasound (SBUS) has become a new method to visualise catheter position at the same time of insertion. Our aim is to analyse the concordance of SBUS and chest radiography (CXR) to assess HDC position, according to the site of insertion: right vs left internal jugular vein (IJV).
Methods
From December 2019 to May 2021, we evaluated 152 hospitalized patients submitted to IJV catheter insertion. We evaluated the time from puncture to CXR result, procedure-related complications, blood flow and the accuracy of SBUS when compared to CXR to detect HDC position adequacy.
Results
The median [IQR] time between catheter insertion and CXR result was 191 [93;288] minutes, no difference between puncture sites. Complications after catheter insertion were mostly arterial puncture (2% overall), similar incidence between sites. The incidence of inadequate blood flow was higher at the left IJV than at the right IJV. For HDC at the right IJV, there was high concordance between position-adequacy assessment by SBUS and CXR (AC1) of Gwet = 0.95, CI: 0.915; 0.992), 95.6% accuracy. For HDC at the left IJV the concordance was low (AC1) of Gwet 0.37, IC: -0.21; 0,94), as was accuracy (64.3%).
Conclusion
Compared with chest radiography, agitated saline bubble-enhanced ultrasound is a suitable method to check catheter placement when right internal jugular vein is used, but not left for internal jugular vein.
Classification of Acceleration Signal in Machining Process for Surface Roughness Identification using Tuned Support Vector Mechanics
Authors: Jamil Norlida , Rosyidi Cucuk Nur , Yusoff Ahmad Razlan 
Published: October 2023

Abstract
In industrial applications, accurate surface roughness identification and characterization are essential for ensuring product quality, dependability, and performance. The suggested technique efficiently processes and examines the acceleration data of a cutting operation for surface quality detection using customized Support Vector Mechanics (SVM). The suggested method extracts pertinent data from the acceleration signals using a number of feature extraction approaches. Incorporating the collected features, the improved SVM model creates a strong classification framework that is capable of precisely recognizing various degrees of surface roughness. An extensive dataset made up of acceleration signals from various machining operations and surface roughness conditions is used to assess the performance of the proposed approach. Using this dataset, the hyper-tuning of the SVM model is trained and tested to determine its classification precision and generalizability. The experimental findings show that, when compared to conventional classification methods, the customized SVM model performs better. The suggested method regularly demonstrates durability and reliability while achieving excellent classification accuracy across a range of surface roughness levels. The suggested method provides a workable and effective solution for automating surface roughness identification, enabling in-process quality control and real-time monitoring.
An Open Source R Package for Detection of Adverse Events Under-Reporting in Clinical Trials - Implementation and Validation by the IMPALA (Inter coMPany quALity Analytics) Consortium
Authors: Koneswarakantha Björn , Adyanthaya Ronojit , Emerson Jennifer , Collin Frederik , Keller Annett , Mattheus Michaela , Spyroglou Ioannis , Donevska Sandra , Ménard Timothé 
Published: October 2023

Abstract

Accurate and timely reporting of adverse events (AE) in clinical trials is crucial to ensuring data integrity and patient safety. However, AE under-reporting remains a challenge, often highlighted in Good Clinical Practice (GCP) audits and inspections. Traditional detection methods, such as on-site investigator audits via manual source data verification (SDV), have limitations. Addressing this, the open-source R package {simaerep} was developed to facilitate rapid, comprehensive, and near-real-time detection of AE under-reporting at each clinical trial site. This package leverages patient-level AE and visit data for its analyses. To validate its efficacy, three member companies from the Inter-coMPany quALity Analytics (IMPALA) consortium independently assessed the package. Results showed that {simaerep} consistently and effectively identified AE under-reporting across all three companies, particularly when there were significant differences in AE rates between compliant and non-compliant sites. Furthermore, {simaerep}'s detection rates surpassed heuristic methods, and it identified 50% of all detectable sites as early as 25% into the designated study duration. The open-source package can be embedded into audits to enable fast, holistic and repeatable quality oversight of clinical trials.
Investigating the Influence of Combined Loads on Pile Behavior and Structural Response
Authors: Daas Suokanda 
Published: October 2023

Abstract
Piles experience a combination of vertical and lateral loads within stratified sand and clay soil settings. The existing body of experimental research specifically focused on embedded piles in layered cohesionless soil under combined loads is limited. This article presents the findings of experimental investigations conducted on laterally loaded piles, driven with varying energy levels, within different conditions of vertical loading in layered sandy soil at diverse densities. The analysis primarily focused on examining the bending moment and strain along the driven aluminum model pile to assess the load deflection response. The results of the study indicate that the lateral deflection tends to decrease with an increase in driving energy within a single layer of sandy soil. This phenomenon can be attributed to the compaction of the surrounding ground and the consequent rise in effective horizontal soil stress during the pile driving process. The comprehensive combined load tests revealed that the presence of vertical loads significantly amplifies the bending moments and lateral deflection of the pile head. This highlights the complex interplay between different load types and soil characteristics, emphasizing the need for a deeper understanding of the behavior of piles under such combined loading conditions.
Water allocation sustainability assessment in climate change: a modeling approach using water footprint and just policy
Authors: Imani Somaye , Niksokhan Mohammad Hossein , Delavar Majid , Safari Shali Reza 
Published: October 2023

Abstract
Climate change has challenged water allocation for food production in water-scarce areas. This fact calls for water reallocation (RA) strategies in basins with dominant agriculture. This study develops a framework combining the SWAT model and water footprint (WF) to evaluate water resource sustainability and improve its indices by fair RA from agriculture. The Karkheh River Basin in Iran was chosen as a study area for verification. Deficit irrigation (DI) was a farm strategy to promote basin sustainability and maintain food security. DI was distributed according to the equality of resources, proposed by Ronald Dworkin, as a just allocation principle. It means irrigated water would be allocated based on an equal water ratio per hectare. Results showed that the basin is currently unsustainable regarding the groundwater (BkWS) and surface flow (BuWS). According to the SSP5-8.5 scenario, the BuWS in the basin increases from 1.12 to 1.22 (9%), and BkWS increases from 2 to 2.15 (7.5%), while GnWS remains relatively constant at 0.99. By Dworkin's principle, DI caused 21-48% reduction in water allocation among five provinces. RA improved the BuWS, GnWS, and BkWS and ensured environmental flow. Climate change reduces 3.5% of food production, with an extra 9% by RA. These reductions would not endanger food security.
Czynniki kształtujące poziom wiedzy na temat wcześniactwa u rodziców dotkniętych tym problemem
Authors: Kleczewska Małgorzata 
Published: October 2023

Wstęp. Przyjście na świat dziecka jest dla rodziców powodem ogromnej radości i szczęścia. Wszystko się zmienia, kiedy do porodu dochodzi przed planowanym terminem. Rodzicom towarzyszy poczucie lęku i bezradności. Czują się zagubieni i przerażeni, szczególnie kiedy dziecko trafia w oddział intensywnej terapii medycznej, gdzie walczy o życie. Zostają otoczeni opieką personelu medycznego, który edukuje, wspiera oraz przekazuje odpowiednie wskazówki na temat pielęgnacji. Edukacja jest prowadzona w zależności od oceny stanu wiedzy rodziców.
Cel. Celem pracy jest ocena poziomu wiedzy rodziców dzieci urodzonych przedwcześnie i hospitalizowanych w oddziałach Kliniki Neonatologii. Starano się wyróżnić czynniki wpływające na poziom wiedzy dotyczący wcześniactwa.
Materiał i metody. Badaniem objęto grupę 174 rodziców (w tym 162 matki i 12 ojców). Wiek respondentów mieścił się w przedziale od 22 do 54 lat. Przeciętny wiek badanych wynosił 32 lata. W pracy wykorzystano metodę sondażu diagnostycznego, stosując kwestionariusz ankiety własnego autorstwa. W narzędziu zastosowano 30 pytań skierowanych zarówno do matek jak i ojców.
Wyniki. Analiza statystyczna zebranego materiału potwierdziła istnienie związku, iż rodzice z wyższym wykształceniem wykazują się wysokim poziomem wiedzy na temat przyczyn porodu przedwczesnego, wcześniaka oraz powikłań związanych z tym okresem. Pozostali respondenci posiadali ogólną wiedzę na temat procedur obowiązujących w oddziałach neonatologicznych takich, jak podawanie surfaktantu, kangurowanie czy laktacja, niezależnie od miejsca zamieszkania czy wieku. Większość badanych wskazywała fundacje jako najbardziej powszechne źródło pomocy i wsparcia rodzicom wcześniaków.
Wnioski. Rodzice z wyższym wykształceniem reprezentowali wyższy poziom wiedzy na temat przyczyn porodu przedwczesnego, wcześniaka oraz powikłań związanych z tym okresem. Natomiast wieloródki w przeprowadzonych badaniach własnych nie wykazywały się statystycznie wyższym poziomem wiedzy aniżeli matki posiadające pierwsze dziecko. Badani respondenci posiadają ogólną wiedzę na temat procedur obowiązujących w oddziałach neonatologicznych i nie było to zależne od miejsca zamieszkania czy wieku, jednak ci z wyższym wykształceniem oraz posiadający dziecko o masie urodzeniowej poniżej 1500 gram wykazali się wiedzą z tego tematu bardziej szczegółową. Ważną rolę wspierającą i edukacyjną wobec rodziców stanowiły pielęgniarki i położne. Oprócz tego istotnym źródłem wsparcia i pomocy w opiniach badanych były fundacje, dlatego należałoby rozpowszechniać wiedzę o różnych formach wsparcia i zachęcać do podejmowania współpracy z nimi.