bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal study on the effect of aerobic exercise intervention on the inhibitory control in college students with internet addiction
Authors: Wang Yi , Li Xiangkun 
Published: February 2025

ObjectivesThis study aimed to investigate the effects of aerobic exercise on reactive inhibitory control in college students with internet addiction, examining both behavioral and electrophysiological changes over time.MethodsA longitudinal study design was adopted, involving 48 male college students with internet addiction who were randomly assigned to either a control group or an experimental group. Participants in the experimental group engaged in 40 min aerobic cycling sessions three times per week for 12 weeks, while the control group maintained their usual physical activity levels without any intervention. A 3 × 2 × 3 mixed-factorial design was utilized, incorporating three time points (pre-experiment, 6 and 12 weeks), two groups (control and experimental), and three electrode sites (Fz, F3, F4). This design enabled the examination of the effects of aerobic exercise on reactive inhibitory control and its temporal dynamics in college students with internet addiction.ResultsA significant main effect of group was observed. Specifically, the experimental group demonstrated a significantly higher Nogo accuracy rate compared to the control group at both the mid-test (P &lt; 0.01) and post-test (P &lt; 0.001). Within the experimental group, the Nogo accuracy rate at the mid-test and post-test was significantly higher than at the pre-test (P &lt; 0.001), with the post-test accuracy rate also significantly higher than the mid-test (P &lt; 0.05). Time-frequency analysis revealed that, under the Nogo task, the energy values in the beta frequency band during the early (100–500 ms) and late (600–750 ms) time windows were significantly higher at the mid-test and post-test compared to the pre-test (P &lt; 0.05), with the post-test values significantly exceeding those at the mid-test (P &lt; 0.05).Conclusion(1) Moderate-intensity aerobic exercise significantly improves reactive inhibitory control in college students with internet addiction, with the magnitude of improvement increasing over the duration of the intervention. (2) Increased beta band energy during the early (100–500 ms) and late (600–750 ms) time windows serve as a key neurophysiological indicator of this enhancement.
The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI
Authors: Ge Shengyang , Xiang Yunting , Hua Xuyun , Wang Zening , Hu Qingfeng , Guo Yijun , Huang Jingqiang , Zhao Chengpeng , Wu Jiajia , Wang Xianli , Sun Chuanyu 
Published: February 2025

BackgroundChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition in urology characterized by chronic pain. The pathogenesis of CP/CPPS remains unclear.MethodsWe enrolled 45 eligible CP/CPPS patients and 45 healthy volunteers. We evaluated their resting-state fMRI data using a comprehensive set of parameters, such as Regional Homogeneity (ReHo) and Degree Centrality (DC), to detect brain abnormalities and identify potential correlates with the clinical manifestations of CP/CPPS. We further categorized the patients into subgroups according to their scores of NIH-CPSI to elucidate the brain changes associated with differing symptom severities.ResultsProfound alterations in brain function were observed in patients with CP/CPPS. These changes involved multiple brain regions identified by DC analysis, including the right anterior cingulate cortex (ACC), left inferior frontal opercular cortex, left amygdala, right middle frontal cortex, and bilateral insula. ReHo analysis revealed significant changes in the right thalamus, left inferior frontal triangular cortex, right superior temporal pole, left ACC, and right superior frontal cortex (cluster &gt;20 voxels, GRF correction, p &lt; 0.05). Analysis using ReHo and DC revealed that brain alterations associated with varying symptom severities were localized in pain perception and modulation regions. Specifically, the DC values in the right ACC showed a linear correlation with the severity of symptoms measured by the NIH-CPSI (AUC = 0.9654, p &lt; 0.0001).ConclusionIn CP/CPPS, we first discovered differences in brain function among patients with varying degrees of severity. The brain alterations of DC in the right ACC might be a potential biomarker for diagnosing and assessing disease severity.
Impact of a 7-day short peptide diet on gut microbiota and metabolomics in septic mice
Authors: Zuo Dan , Zuo Binyu , Wang Liuyang , Hu Dabi , Yang Yang , Chen Yong , Huang Biao 
Published: February 2025

ObjectiveOur study aim is to explore the mechanisms of short peptide passages on intestinal dysfunction in septic mice utilizing a metabolomics approach, which provides a new scientific basis for the clinical study of sepsis.MethodsMices were allocated at random into four groups: control (Con), cecal ligation and puncture followed by one, three or 7 day short-peptide-based enteral nutrition group (CLP + SPEN1), (CLP + SPEN3), and (CLP + SPEN7) groups. A liquid chromatography-mass spectrometry-based metabolomics method was used to analyze changes in serum metabolites in septic mice.ResultsShort peptides showed effectiveness in reducing symptoms, mucosal inflammation, and intestinal function damage scores in septic mice. The 16sRNA analysis showcased significant variances in the distribution of bacterial communities between the CLP + SPEN1, CLP + SPEN3, and CLP + SPEN7 groups. At the phylum level, statistically significant variances in the relative abundance of Proteobacteria, Firmicutes, and Bacteroidetes were recognized. The metabolomics analysis results showed significant separation of metabolites between the CLP + SPEN1 and CLP + SPEN3 groups, as well as significant differences in metabolite profiles between the CLP + SPEN3 and CLP + SPEN7 groups. Utilizing a differential Venn diagram, four metabolites were commonly different; 10-heptadecanoic and dodecanoic acids had statistical significance. The abundance of both dodecanoic and lactic acid bacteria was negatively associated at the genus level.ConclusionShort peptides were found to promote the growth of beneficial bacteria, Lactobacillus and uncultured_bacterium_f_Muribaculaceae, while reducing intestinal metabolites such as Dodecanoic acid and 10-Heptadecenoic acid. Moreover the Lactobacillus may play a significant therapeutic role in the treatment of sepsis. However, due to the limited number of experimental samples, the exact mechanism of action of short peptides awaits further confirmation.
Surgical treatment of rare peripheral nerve lesions: long-term outcomes and quality of life
Authors: Savić Andrija , Lepić Milan , Grujić Jovan , Mićić Aleksa , Stojiljković Aleksandra , Putra Gunna Hutomo , Terzić Andrej , Vujić Lazar , Rasulić Lukas 
Published: February 2025

IntroductionRare peripheral nerve lesions comprise a histologically diverse group of neoplastic and non-neoplastic entities, characterized by infrequent occurrence and variable clinical presentations, presenting significant diagnostic and therapeutic challenges. This study presents eight cases of surgically treated rare peripheral nerve lesions with previously unreported long-term outcomes involving quality of life (QOL) assessment.MethodsA retrospective analysis was conducted on medical records from 2012 to 2022 to identify surgically treated cases of rare peripheral nerve lesions, selecting eight cases based on determined inclusion and exclusion criteria. Long-term outcomes and QOL were assessed 12 months post-surgery by patient examination, control imaging and self-reporting questionnaires.ResultsThe study included 4 benign (hemangioblastoma, angiomatoid fibrous histiocytoma, endometriosis (n=2)) and 4 malignant lesions (NTRK-rearranged spindle cell neoplasm, lymphoma, metastatic breast carcinoma (n=2)). Even though benign lesions generally presented with better outcomes, this was more closely related with level of nerve invasion and postoperative sequele, rather than presence of malignancy.DiscussionBecause of a global lack of experience in handling such cases, this study aimed to present the cases we encountered in detail to serve as a basis for future literature reviews. The findings highlight the importance of individualized treatment strategies and long-term follow-up to optimize functional recovery and patient well-being.
Diagnostic value of magnetic resonance imaging for malignant ovarian tumors mis-subclassified by the ultrasound-based ADNEX model
Authors: Jiang Meijiao , Yuan Congcong , Lu Siwei , Zhu Yunkai , Chu Caiting , Li Wenhua 
Published: February 2025

ObjectiveAccurately predicting metastatic cancer to the adnexa, stage I and advanced ovarian cancer before surgery is crucial. The ADNEX model, based on ultrasound, is currently the only prediction model that can differentiate between these types. This study aims to analyze MRI features and diagnostic value in malignant ovarian tumors mis-subclassified by the ADNEX model, considering their diverse histopathologic types.MethodsFrom January 2018 to September 2022, 164 patients with pathologically confirmed ovarian malignancies were selected from those who were examined by ultrasound. The clinical and MRI characteristics of 51 patients mis-subclassified by the ADNEX model were compared with histopathological types.ResultsA total of 30 were confirmed with primary ovarian cancer (5 with HGSOC, 14 with CCC, 2 with EC, 4 with MC, 2 with GCT, 1 with YST, 1 with immature teratoma, and 1 with dysgerminoma). There were 21 patients who had metastatic ovarian tumors (10 with colorectal cancer, 4 with gastric cancer, 2 with uterine cervical cancer, 3 with endometrial cancer, 1 with breast cancer, and 1 with LAMN). The only significant difference between the two groups was in CEA. The mean diameters of the primary and metastatic ovarian tumors were 10.29 cm (range: 3.61 cm–26.02 cm) and 8.58 cm (range: 3.10 cm–20.30 cm), respectively. A total of 42 masses were lobulated (82.35%, 42/51), and 26 masses were solid-cystic (26/51, 50.98%). There was a significant difference between CCC and other tumors, with mean ADC values of 1.01 × 10−3 mm2/s (range: 0.68–1.28×10−3 mm2/s) and 0.74×10−3 mm2/s (range: 0.48–0.99×10−3 mm2/s), respectively (P=0.000). A total of 50 masses presented isointense-T1, hyperintense-T2, and hyperintense-DWI signal on MRI (50/51,98.04%). There were 33 masses that showed intensive enhancement (33/51,64.71%). There were 17 masses who had necrosis (17/51, 33.33%), with the majority being HGSOC and ovarian metastases from colorectal and gastric cancers (12/17, 70.59%). There were 19 masses that presented hemorrhage (19/51,37.25%), with the majority being CCC (10/19, 52.63%). A total of 46 masses were diagnosed correctly by MRI (46/51,90.20%). There were 35 and 15 masses that were rated as O-RADS score 5 and score 4, respectively. One mass was rated as score 3.ConclusionsDWI signal, ADC value, degree of enhancement, and characteristic components within the mass on MRI can provide supplementary information for malignant ovarian tumors mis-subclassified by the ADNEX model.
Evolving paradigms in prostate cancer screening: a decade of bibliometric insights and technological advancements
Authors: Chai Keqiang , Xu Changhong , Man Jiangwei , Deng Yun , Yang Li 
Published: February 2025

ObjectiveProstate cancer is a major threat to global male health. This study uses bibliometric methods to analyze the dynamics and trends in prostate cancer screening research, with the aim of optimizing screening strategies and informing policy decisions.MethodsUtilizing the Web of Science Core Collection database, this study retrieved prostate cancer screening-related literature published between 2014 and 2024, totaling 5,409 articles. Data processing and analysis were conducted using CiteSpace and the Bibliometrix R package, including citation network analysis, co-word analysis, cluster analysis, and trend analysis.ResultsThe analysis revealed the following key findings: (1) Global literature on prostate cancer screening has grown annually, with the United States, Europe, and China leading research activity; (2) Research hotspots include the risks and benefits of prostate-specific antigen (PSA) testing, MRI-based screening technologies, and the use of molecular and genetic biomarkers; (3) Emerging technologies, such as machine learning and nanodiagnostic techniques, are enhancing diagnostic precision and reducing overdiagnosis; (4) Network analysis of collaborations reveals a shift toward transnational and interdisciplinary research, particularly in integrating biomedical and computer science to drive rapid advancements in screening technologies.ConclusionThis study confirms the ongoing vibrancy and technological advancement in the global field of prostate cancer screening research, emphasizing the trend towards precision medicine. Future development of prostate cancer screening strategies should focus on risk-adapted screening and the application of novel biomarkers to optimize screening outcomes and reduce unnecessary medical interventions.
Associations of maternal age with outcomes in very low birth weight singleton infants: a retrospective study
Authors: Sun Junfang , Sun Mengya , Zhang Lulu , Lai Chunchi , Jiang Hong 
Published: February 2025

BackgroundWith advances in perinatal medicine, there has been a rise in the preterm birth rate, especially the rate of very low birth weight (VLBW) and extremely low birth weight infants. Studies have shown that maternal age during pregnancy and at the time of delivery is associated with pregnancy complications and poor neonatal outcomes. Little is known about the effect of maternal age on the outcome of very low birth weight infants.ObjectivesTo investigate the effects of maternal age on the adverse outcomes of singleton very low birth weight neonates.MethodsWe used data of VLBW infants from the neonatal database of our hospital. Maternal age was categorized as 20–24, 25–34 (reference group), 35–39 and ≥40 years. Statistical analyses included univariate and multivariate logistic regression analysis.ResultsThe study ultimately included 603 singleton, very low birth weight infants. After adjustment, neonatal outcomes in the group of older mothers were similar to those of the reference group for bronchopulmonary dysplasia, necrotizing enterocolitis, respiratory distress syndrome, severe asphyxia, retinopathy of prematurity and intraventricular hemorrhage grades 3–4. In the 20–24 year age group higher odds were present for sepsis [Odds ratio (OR) = 6.021; 95% confidence interval (CI), 1.741–20.818, p &lt; 0.05] and for mortality (OR = 7.784; 95% CI, 2.198–27.568, p &lt; 0.05). Higher odds for asphyxia (OR = 1.891; 95% CI, 1.238–2.890, p &lt; 0.05) and death (OR = 2.101, 95% CI, 1.004–4.395, p &lt; 0.05) were observed in infants of mothers in the 35–39 year age group. The incidence of sepsis was significantly higher in the age group of ≥40 years (OR = 2.873; 95% CI, 1.186–6.958, p &lt; 0.05).ConclusionsIn singleton very low birth weight neonates, neonatal outcomes were associated with maternal age, and adverse outcomes were more pronounced in infants of advanced maternal age (AMA) mothers.
Knowledge structure and dynamic evolution of nanomedicine in liver cancer research: a scientometric analysis and visualization
Authors: Li Shaodong , Cui Dapeng , Shao Bo , Kang Zhenhua , Yan Guoqiang 
Published: February 2025

BackgroundNanomedicine has received much attention for its potential applications in the diagnosis and treatment of liver cancer. However, no bibliometric evaluation has been conducted to present an assessment of scientific progress in the field. The aim of this study is to comprehensively catalog the cooperation and influence of journals, countries, institutions, and authors in the field of nanomedicine in liver cancer from the perspective of bibliometrics, evaluate the clustering evolution of knowledge structure, and uncover hot topics and emerging themes.MethodsArticles and reviews related to nanomedicine and liver cancer were retrieved from the Web of Science Core Literature Library using Topic Search. #1 T= (“Hepatic Neoplasm*” OR “Liver Neoplasm” OR “Liver Cancer*” OR “Hepatocellular Cancer*” OR “Hepatic Cancer*“), #2 T= “nano*“, the search strategy is set as #1 AND #2 limited to Science Citation Index Expanded database source, with no limitation of publication types and language/time. Bibliometric studies were conducted using CiteSpace and VOSviewer.Results2,648 articles and reviews were included from 2000 to 2024. The number of articles regarding nanomedicine in liver cancer showed an increasing trend. Analysis of the most productive journals shows that most are specialized in nanoscience and nanotechnology, pharmacology and pharmacy, and chemistry and multidisciplinary. These publications mainly come from 8,782 institutions in 297 countries led by China and the United States of America. Shao D published the most papers among the publications, while Jemal A had the most co-citations. The macroscopical sketch and micro-representation of the whole knowledge field are realized through co-citation analysis. Hepatocellular carcinoma, targeted delivery, sorafenib nanoparticles, and others are current and developing areas of study. The keywords “nanocrystals,” “biodistribution,” and “particles” also may be the focus of new trends and future research.ConclusionIn this study, bibliometrics and visual methods were used to review the research of nanomedicine in liver cancer comprehensively. The article will help scholars to gain a better understanding of the dynamic evolution of nanomedicine applications in liver cancer and point the directions for future research.
Aspirin-triggered DHA metabolites inhibit angiogenesis
Authors: Vara-Messler M. , Trevisi L. , Zulato E. , Ramaschi G. E. , Risé P. , Pinna C. , Indraccolo S. , Sala A. , Bolego C. 
Published: February 2025

Background and aimBlood vessels supply oxygen, nutrients and provide gateways for immune surveillance. Since this network nourishes all tissues, vessel abnormalities contribute to many diseases, such as cancer. One of the potential targets for Docosahexaenoic Acid (DHA) in cancer is suppressing angiogenesis, a process of new blood vessel formation within tumors. In addition, aspirin (ASA) has antineoplastic effects that may be mediated, at least in part, by metabolites derived from acetylated COX-2. We aimed at determining the effect of DHA as well as its metabolites in angiogenesis, using in vitro as well as in vivo models.MethodsEndothelial cell (EC) proliferation, motility and capillary-like tube formation were determined by MTT, wound healing, Boyden and Matrigel assays, respectively. In vivo angiogenesis was measured by the Matrigel sponge model in mice. The biosynthesis of proresolving lipid mediators by ECs was determined by LC-MS-MS.Results and conclusionDHA, but not arachidonic acid (AA), at concentrations consistent with those reached in blood after fish oil supplementation, decreased EC migration in a time- and concentration-dependent manner. Pretreatment with ASA modulated cell migration already after 24 h, while both DHA and ASA decreased migration at longer incubation times without affecting viability. 17-hydroxy-DHA was detected upon incubation with DHA, and increased amounts were observed upon combined treatment with DHA and ASA, an increase that was associated to a synergic effect on EC migration. 17(R)-hydroxy-DHA (17R-HDHA), the metabolite resulting from acetylated COX-2 activity of DHA, reduced EC migration in a concentration-dependent manner. DHA in the presence of ASA, as well as 17R-HDHA, also reduced EC tube formation. These results were confirmed in vivo where both 17R-HDHA or its downstream metabolite 17RResolvinD1 were able to decrease microvessels density in a Matrigel sponge model. Overall, we demonstrated that DHA in the presence of ASA-dependent acetylation of COX-2 showed increased antiangiogenic effects, possibly resulting from its conversion to its hydroxylated derivatives.
Targeting TRPV1 channels in desensitized neural afferent pathways may help mitigate pain and lower urinary tract symptoms caused by prostatitis
Authors: Jiang ZhiPeng , Li AnGuo , Luo Wen , Luo XiKe , Liang DeCan , Li Jing , Tang KaiHua , Liu Lei , Long ZongMin , Miao Ruiyu , Jian Lei , Gong XiaoChuan , Li ShangJun , Zhang Yang , Yuan ChaoYong 
Published: February 2025

Chronic prostatitis/chronic pelvic pain syndrome (CPPS/CP) is a prevalent urinary disorder primarily characterized by pelvic pain and discomfort, bladder dysfunction, and sexual dysfunction. Currently, there is no effective method to alleviate the pain and lower urinary tract symptoms associated with chronic prostatitis. Resiniferatoxin (RTX), a highly potent TRPV1 receptor agonist, functions as a molecular analgesic by desensitizing TRPV1-expressing nerves. While RTX has demonstrated significant efficacy in treating various conditions, research on its application for prostatitis remains lacking. Consequently, we established a prostatitis model to investigate whether RTX could alleviate the symptoms associated with this condition. Our observations indicated that both low-dose (200 μg/kg) and high-dose (300 μg/kg) RTX effectively relieved pain and lower urinary tract symptoms caused by prostatitis. We noted that RTX reduced the expression of central pain-inducing substance P by reducing TRPV1 expression in the dorsal root ganglia (DRG), thereby mitigating pain. RTX also desensitizes bladder nerves by reducing TRPV1 expression in the bladder, which helps alleviate lower urinary tract symptoms caused by prostatitis. Collectively, these findings suggest that RTX may serve as a viable treatment option for alleviating prostatitis-induced pain and lower urinary tract symptoms through neural desensitization, presenting a promising therapeutic avenue for patients with prostatitis.
Changes in shooting accuracy among basketball players under fatigue: a systematic review and meta-analysis
Authors: Li Shuairan , Luo Yuanyuan , Cao Yingying , Li Feng , Jin Haodong , Mi Jing 
Published: February 2025

ObjectiveTo investigate the influence of physical and mental fatigue of different intensities (mild, moderate or severe) on basketball shooting accuracy, with the aim of informing more effective training protocols and competition strategies.MethodsLiterature searches were conducted on Web of Science, PubMed, and EBSCO databases up to 25 June 2024. Inclusion and exclusion criteria were specified, and data extraction sheets were prepared. Study quality was assessed by using the Cochrane Risk of Bias Tool in Review Manager 5.4, and Stata18.0 software was used for heterogeneity analysis, subgroup analysis, forest plots, stratification analysis, and bias assessment.ResultsModerate physical fatigue affected two-point shooting accuracy (P &lt; 0.01),severe physical fatigue affected both two-point (P = 0.02) and three-point shooting accuracy (p &lt; 0.01),with severe physical fatigue showing a greater detrimental impact on three-point shooting accuracy, while two-point shooting accuracy may vary under specific conditions. Additionally, adolescent athletes were less affected by severe physical fatigue compared to adult athletes or those with longer training experience. Moderate mental fatigue also significantly reduced free-throw accuracy (p &lt; 0.01).ConclusionThe shooting accuracy of basketball players was significantly affected by moderate and severe physical fatigue. Severe physical fatigue notably adversely affected the accuracy of three-point shooting relative to moderate fatigue; Additionally, moderate mental fatigue significantly reduced free-throw accuracy, which may be attributed to a decline in cognitive executive functions, highlighting the importance of fatigue management in sports training.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/#myprospero, identifier CRD42024539553