bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Critical Period for Alcohol or Other Drug-Related Presentations Following Access to Residential Substance Use Treatment: a Data Linkage Study
Authors: Tisdale Calvert , Leung Janni , de Andrade Dominique , Hides Leanne 
Published: February 2024

AbstractIndividuals who access residential treatment for substance use disorders are at a greater risk of negative health and substance-use outcomes upon exiting treatment. Using linked data, we aimed to identify predictive factors and the critical period for alcohol or other drug (AOD)-related events following discharge. Participants include 1056 individuals admitted to three residential treatment centres in Queensland, Australia from January 1 2014 to December 31 2016. We linked participants’ treatment data with administrative data from hospitals, emergency departments, AOD services, mental health services and the death registry up to December 31 2018. We used survival analysis to examine presentations for AOD-related events within two-years of index discharge. A high proportion of individuals (57%) presented to healthcare services for AOD-related events within 2 year of discharge from residential treatment, with the first 30 days representing a critical period of increased risk. Completing residential treatment (aHR = 0.49 [0.37–0.66], p < .001) and high drug-abstaining self-efficacy (aHR = 0.60 [0.44–0.82], p = .001) were associated with a reduced likelihood of AOD-related events. Individuals with over two previous residential treatment admissions (aHR = 1.31 [1.04–1.64], p = .029), identifying as Indigenous Australian (aHR = 1.34 [1.10–1.63], p < .001), alcohol as a primary substance (aHR = 1.58 [1.30–1.92], p < .001), and receiving a Disability Support Pension (aHR = 1.48 [1.06–2.06], p = 0.022) were at a greater likelihood. The high proportion of individuals that present to health and drug services for AOD-related events, especially in the first 30 days post-discharge, highlights the need for continued support following discharge from substance use treatment.
Assessing the relevance of different proximity dimensions for knowledge exchange and (co-)creation in sustainability-oriented innovation networks
Authors: Wilke Ulrich , Pyka Andreas 
Published: February 2024

AbstractInnovations incorporating environmental and social considerations can address many sustainability challenges. Such sustainable innovations emerge in networks often comprising actors from business, academia, civil society, and government. The crucial interactions here are the (co-)creation and transfer of knowledge, mutual learning, and experimentation in different environments. To better understand these knowledge processes and hence the eventual outcome of sustainable innovations, we analyze the actors’ relationships with the help of proximity and its five dimensions, namely geographical, cognitive, institutional, organizational, and social proximity. Building upon findings from sustainability science and innovation system theory, we present a refined proximity framework, introducing a differentiation of institutional proximity into micro- and macro-institutional proximity and a differentiation of cognitive proximity into systems-cognitive, normative-cognitive, and transformative-cognitive proximity. Analyzing examples from the literature by applying this framework, we see that all proximity dimensions and their interdependencies help to better understand knowledge processes and innovations in sustainability-oriented innovation networks. We find that such networks often depict low levels of micro-institutional and systems-cognitive proximity, which coheres with the prevalence of inter- and transdisciplinary approaches and the wide inclusion of relevant stakeholders for addressing sustainability issues. Our framework further reveals that successful networks show high levels in other proximity dimensions, with normative-cognitive proximity appearing to play a crucial role, highlighting the importance of shared goal orientations. Our results provide valuable input for the formation of sustainability-oriented innovation networks by pointing out the necessary combination of distances that allow for creativity and learning, combined with appropriate proximities for exchange and mutual understanding.
Overview of Highly Solvating Electrolytes for Lean Electrolyte Conditions in Lithium–Sulfur Batteries
Authors: Kang Taemin , Kang Naehyun , Choi Jang Wook 
Published: February 2024

AbstractLithium-sulfur (Li–S) batteries are considered the next generation of lithium-ion batteries due to their high energy density, but they face challenges in operation under lean electrolyte conditions. Among the potential strategies, highly solvating electrolytes (HSEs) have become a prominent option. These electrolytes offer strong solvation of polysulfide intermediates, leading to modified sulfur reaction pathways and deposition morphologies compared to conventional electrolytes. This review presents a comprehensive summary of HSEs in Li–S batteries, with a focus on their development and optimization for broad applications.
Role of Memantine in Limiting Cochleotoxicity in Rats
Authors: Pavlidis Pavlos , Tseriotis Vasilis Spyridon , Papadopoulou Kyriaki , Karachrysafi Sophia , Sardeli Chrysanthi , Gouveris Haralampos , Malliou Faye , Kavvadas Dimitrios , Papamitsou Theodora , Sioga Antonia , Anastasiadou Penelope , Kouvelas Dimitrios 
Published: February 2024

AbstractΟur aim was to test whether amikacin’s well-known cochleotoxic effects could be suppressed, depending on whether an NMDA-antagonist (memantine) was administered simultaneously with or after amikacin treatment. Forty Wistar rats were used in this experiment. Ten rats acted as controls and received no medication (group A). Amikacin (200 mg/kg) was administered intraperitoneally (i.p.) once daily for 14 days to 10 animals in group B; amikacin (200 mg/kg) was administered concurrently with memantine (10 mg/kg, i.p., once daily) to the same 10 animals in group C. Group D was given intraperitoneal memantine (10 mg/kg, once daily) for 14 days following a 2-week amikacin treatment. The cochlear activity of the right ear was tested using DPOAE in conscious animals. All animals were sacrificed at the conclusion of the experiment and both cochleae were collected for histological and immunohistochemical analysis. All groups treated with amikacin showed decreased cochlear activity, as testified by decreased DPOAE-amplitudes compared to the pre-treatment state. In the rats of group B, the DPOAE reduction was more pronounced. On histologic exam, the cochlear structures of group C rats and, although to a lesser extent, group D rats showed less severe cochlea damage. Memantine plays a protective role, resulting in restoring partially cochlear structures when administered either simultaneously with or after completion of amikacin i.p. treatment in rats.
Biocarbon-Enhanced Flexible Nanofiber Mats for Sustainable Energy Generation and Wearable Device Applications
Authors: Ali Nehal , Mostafa Elham M. 
Published: February 2024

AbstractA broad diversity of nanofillers and polymers have been used to prepare polymer nanocomposites having potential applications in transportation, sports materials, aerospace, electronics, communication, energy, environment, and biomedical. Polyvinylidene fluoride (PVDF) finds a remarkable place in energy applications attributed to its highest known piezo- and pyroelectric properties. Like most carbon materials, Biochar has excellent electrical conductivity, since it comprises graphene layers with a great amount of carbon content. This study explores the behavior of composite nanofibers fabricated from rice straw-derived biochar-PVDF as wearable mats to harvest body energy into electricity. The composite nanofiber mats were fabricated using the electrospinning technique to get the benefit of both the piezoelectric properties of PVDF and the excellent electric properties of Biochar. The research found that incorporating 12 wt % of Biochar greatly enhances the piezoelectric content of the nanofiber mats without noteworthy loss in flexibility. In addition, the effects of membrane thickness (0.5, 0.9, and 1 mm) on their output voltages as a performance factor of the nanogenerator were measured. Results indicated that the effect of thickness was most influential in the thickness of 1 mm of PVDF/biochar nanofibers generator. The results of this work imply promising application development of such flexible composite piezoelectric nanofibrous membranes for environmentally sustainable energy generation and wearable self-powered electrical devices.
Significant augmentation of proton conductivity in low sulfonated polyether sulfone octyl sulfonamide membranes through the incorporation of hectorite clay
Authors: Mabrouk Walid , Charradi Khaled , Kacem Imen Ben , Lafi Ridha , Bellakhal Nizar , Marzouki Riadh , Keshk Sherif M. A. S. 
Published: February 2024

AbstractAn innovative methodology was employed to fabricate ion exchange membranes tailored for fuel cell applications. This approach entailed blending low sulfonated polyether sulfone octyl sulfonamide (LSPSO) with Hectorite (Hect) clay at varying weight percentages (1 wt%, 3 wt%, and 6 wt%). The resultant composite membranes underwent comprehensive characterization via Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermogravimetric analysis, aiming to assess their surface morphology and thermal resilience. Remarkably, the thermal stability of the composite membrane exhibited a substantial enhancement in comparison to the pristine LSPSO membrane. Moreover, the incorporation of 6 wt% Hectorite into the composite membrane yielded a noteworthy amplification in proton conductivity, achieving a fourfold increase (141.66 mS/cm) as opposed to the LSPSO membrane in isolation (35.04 mS/cm). Consequently, the Hect/LSPSO composite membrane exhibits remarkable potential as an electrolyte membrane for fuel cells operating at temperatures surpassing 100 °C.
The “we” factor in improvisational statecraft: frontline repair of the state in Indonesia’s crisis response amidst resource constraints
Authors: Ningrum Ayu Puspita , Lotta Gabriela 
Published: February 2024

AbstractStreet-level bureaucrats, confined by meager discretion, often find themselves reconciling the challenging terrain of inflexible policies with messy frontline realities. With a phenomenological lens, we examine how Indonesia’s frontline healthcare workers exercise discretion and improvise informal practices to adapt policies and deliver care despite scarce resources during the COVID-19 crisis. As formal emergency protocols lie encumbered under conditions of austerity, a grassroots motivation for communal action occurs from exchanges between peers mired in resource quandaries, encapsulating an improvisational “we” cohering frontline allies. Manifesting through focused responses drawing on unwritten collegial knowledge, these collaborative efforts embody the relational essence and defining contours of frontline policy repair, as opposed to isolated discretion. Probing further into these repair processes surfaces how shared struggles have the power to ignite collective capacity, empowering bureaucrats to govern complexity in concert, construct agency despite constraints, and promote equity in times of scarcity. Our findings champion tending to institutional receptivity and solidarity-anchored creative frontline initiatives, endorsing agile, adaptive processes finely tuned to situational realities that contests paradigms fixated solely on compliance.
Explainable and transparent artificial intelligence for public policymaking
Authors: Papadakis Thanasis , Christou Ioannis T. , Ipektsidis Charalampos , Soldatos John , Amicone Alessandro 
Published: February 2024

Abstract
Nowadays public policymakers are offered with opportunities to take data-driven evidence-based decisions by analyzing the very large volumes of policy-related data that are generated through different channels (e.g., e-services, mobile apps, social media). Machine learning (ML) and artificial intelligence (AI) tehcnologies ease and automate the analysis of large policy-related datasets, which helps policymakers to realize a shift toward data-driven decisions. Nevertheless, the deployment and use of AI tools for public policy development is also associated with significant technical, political, and operation challenges. For instance, AI-based policy development solutions must be transparent and explainable to policymakers, while at the same time adhering to the mandates of emerging regulations such as the AI Act of the European Union. This paper introduces some of the main technical, operational, regulatory compliance challenges of AI-based policymaking. Accordingly, it introduces technological solutions for overcoming them, including: (i) a reference architecture for AI-based policy development, (ii) a virtualized cloud-based tool for the specification and implementation of ML-based data-driven policies, (iii) a ML framework that enables the development of transparent and explainable ML models for policymaking, and (iv) a set of guidelines for using the introduced technical solutions to achieve regulatory compliance. The paper ends up illustrating the validation and use of the introduced solutions in real-life public policymaking cases for various local governments.
A new wall function method for hypersonic laminar boundary layers
Authors: Mo Fan , Gao Zhenxun 
Published: February 2024

A new wall function method for hypersonic laminar boundary layers (HLBLs) is proposed to reduce the near-wall grid dependence of skin friction

$c_f$

and wall heat flux

$q_w$

in numerical simulations, aiming for fast and accurate predictions. First, an analytic laminar velocity law of the wall is derived, which achieves a universal scaling of the near-wall velocity of HLBLs. Then an accurate temperature–velocity relation is deduced by introducing the general recovery factor to address the invalidation of the Walz relation under the cold wall effect. Based on the laminar laws of the wall, a new wall function method for HLBLs is proposed. To avoid introducing the boundary layer edge quantities, the laminar laws of the wall are reformed by modifying the outer boundary conditions of the differential equation in deriving the temperature–velocity relation. Unlike the wall function method in turbulence, the new wall function obtains directly the accurate

$c_f$

and

$q_w$

by post-processing without being involved in the simulation iteration. The numerical experiments of a Mach 8 HLBL over the flat plate show that effectively, the new wall function can enlarge the distance of the first grid point off the wall

$\Delta y_1$

from

$10^{-6}$

m to

$10^{-3}$

m, which brings a 50 times enhancement of the simulation efficiency. Meanwhile, the simulation errors of

$c_f$

and

$q_w$

of the mesh with

$\Delta y_1=10^{-3}$

m are reduced significantly from 24.2 % and 18.5 % to 0.5 % and 0.1 %, respectively. Due to the new wall function removing the boundary layer edge quantities, success is also achieved under the curved walls.
Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris
Authors: Bråtveit Marianne , Van Parys Anthea , Olsen Thomas , Strand Elin , Marienborg Ingvild , Laupsa-Borge Johnny , Haugsgjerd Teresa Risan , McCann Adrian , Dhar Indu , Ueland Per Magne , Dierkes Jutta , Dankel Simon Nitter , Nygård Ottar Kjell , Lysne Vegard 
Published: February 2024

Abstract
Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations of these markers. We cross-sectionally analysed 1928 patients with suspected stable angina pectoris (geometric mean age 61), representing elevated CVD risk, to assess associations between dietary macronutrient composition (FFQ) and plasma one-carbon metabolites and related B-vitamin status markers (GC–MS/MS, LC–MS/MS or microbiological assay). Diet-metabolite associations were modelled on the continuous scale, adjusted for age, sex, BMI, smoking, alcohol and total energy intake. Average (geometric mean (95 % prediction interval)) intake was forty-nine (38, 63) energy percent (E%) from carbohydrate, thirty-one (22, 45) E% from fat and seventeen (12, 22) E% from protein. The strongest associations were seen for higher protein intake, i.e. with higher plasma pyridoxal 5’-phosphate (PLP) (% change (95 % CI) 3·1 (2·1, 4·1)), cobalamin (2·9 (2·1, 3·7)), riboflavin (2·4 (1·1, 3·7)) and folate (2·1 (1·2, 3·1)) and lower total homocysteine (tHcy) (–1·4 (–1·9, −0·9)) and methylmalonic acid (MMA) (–1·4 (–2·0, −0·8)). Substitution analyses replacing MUFA or PUFA with SFA demonstrated higher plasma concentrations of riboflavin (5·0 (0·9, 9·3) and 3·3 (1·1, 5·6)), tHcy (2·3 (0·7, 3·8) and 1·3 (0·5, 2·2)) and MMA (2·0 (0·2, 3·9) and 1·7 (0·7, 2·7)) and lower PLP (–2·5 (–5·3, 0·3) and −2·7 (–4·2, −1·2)). In conclusion, a higher protein intake and replacing saturated with MUFA and PUFA were associated with a more favourable metabolic phenotype regarding metabolites associated with CVD risk.
Naturally acquired immunity to Plasmodium pitheci in Bornean orangutans (Pongo pygmaeus)
Authors: Sánchez Karmele Llano , Baird John Kevin , Nielsen Aileen , Nurillah Andini , Agustina Fitria , Komara  , Fadilah Fina , Prameswari Wendi , Nugraha Raden Taufiq Purna , Saputra Sugiyono , Nurkanto Arif , Dharmayanthi Anik Budhi , Pratama Rahadian , Exploitasia Indra , Greenwood Alex D. 
Published: February 2024

AbstractNaturally acquired immunity to the different types of malaria in humans occurs in areas of endemic transmission and results in asymptomatic infection of peripheral blood. The current study examined the possibility of naturally acquired immunity in Bornean orangutans, Pongo pygmaeus, exposed to endemic Plasmodium pitheci malaria. A total of 2140 peripheral blood samples were collected between January 2017 and December 2022 from a cohort of 135 orangutans housed at a natural forested Rescue and Rehabilitation Centre in West Kalimantan, Indonesia. Each individual was observed for an average of 4.3 years during the study period. Blood samples were examined by microscopy and polymerase chain reaction for the presence of plasmodial parasites. Infection rates and parasitaemia levels were measured among age groups and all 20 documented clinical malaria cases were reviewed to estimate the incidence of illness and risk ratios among age groups. A case group of all 17 individuals that had experienced clinical malaria and a control group of 34 individuals having an event of >2000 parasites μL−1 blood but with no outward or clinical sign of illness were studied. Immature orangutans had higher-grade and more frequent parasitaemia events, but mature individuals were more likely to suffer from clinical malaria than juveniles. The case orangutans having patent clinical malaria were 256 times more likely to have had no parasitaemia event in the prior year relative to asymptomatic control orangutans. The findings are consistent with rapidly acquired immunity to P. pitheci illness among orangutans that wanes without re-exposure to the pathogen.
Are specialist-provided end-of-life scenarios key to initiation of advance care planning in primary care? A mixed-methods study
Authors: Poelman Sophie W. , Ermers Daisy J.M. , Schers Henk J. , Vissers Kris C.P. , Veldhoven Carel M.M. , Kuip Evelien J.M. , Perry Marieke 
Published: February 2024

AbstractObjectivesSpecialist-provided end-of-life scenarios (SP-EOLS) may improve advance care planning (ACP) implementation in primary care by helping overcome barriers such as uncertain prognosis and poor interprofessional collaboration. We aimed to explore the current use and potential impact of SP-EOLS on ACP in Dutch primary care.MethodsWe performed a mixed-methods study. From patients discussed in a hospital-based academic palliative care multidisciplinary team meeting between 2016 and 2019 and died, we collected primary care electronic medical records data on SP-EOLS, actual EOLS, and ACP initiation and applied descriptive and comparative analyses. Subsequently, we interviewed general practitioners (GPs) and thematically analyzed the transcripts.ResultsIn 69.7% of 66 reviewed patient files, SP-EOLS were found. In patients whose GP had received SP-EOLS, ACP conversations were more often reported (92.0 vs. 61.0%, p = 0.006). From 11 GP interviews, we identified 4 themes: (1) SP-EOLS guide GPs, patients, and relatives when dealing with an uncertain future perspective; (2) SP-EOLS provide continuity of care between primary and secondary/tertiary care; (3) SP-EOLS should be tailored to the individual patient; and (4) SP-EOLS need to be personalized and uniformly transferred to GPs.Significance of resultsSP-EOLS may facilitate ACP conversations by GPs. They have the potential to help overcome existing barriers to ACP implementation by providing guidance and supporting interprofessional collaboration. Future research should focus on improving SP-EOLS and tailor them to the needs of all end users, focusing on improving their effect on ACP conversations.
Health‐Damaging Climate Events Highlight the Need for Interdisciplinary, Engaged Research
Authors: Stowell Jennifer D. , Anenberg Susan , Zaitchik Benjamin F. , Tong Daniel Q. , Horwell Claire J. , Stolle Dennis P. , Colwell Rita R. , McEntee Christine 
Published: February 2024

AbstractIn 2023 human populations experienced multiple record‐breaking climate events, with widespread impacts on human health and well‐being. These events include extreme heat domes, drought, severe storms, flooding, and wildfires. Due to inherent lags in the climate system, we can expect such extremes to continue for multiple decades after reaching net zero carbon emissions. Unfortunately, despite these significant current and future impacts, funding for research in climate and health has lagged behind that for other geoscience and biomedical research. While some initial efforts from funding agencies are evident, there is still a significant need to increase the resources available for multidisciplinary research in the face of this issue. As a group of experts at this important intersection, we call for a more concerted effort to encourage interdisciplinary and policy‐relevant investigations into the detrimental health effects of continued climate change.