bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of ellagic acid action in 5-fluorouracil induced intestinal mucositis
Authors: Al-hoshary Dareen , Munaf H. Zalzala  
Published: November 2023

The intestinal mucositis define as inflammation and ulceration in the gastrointestinal tract wall and in some case in the oral cavity these cause by treatment with antineoplastic drug like 5-fluorouracil and Irinotecan and other types of chemotherapeutics drugs , 5-Fluorouracil-induced intestinal mucositis (IM) is consider as one of the more common tumor issue .it cause series of undesirables symptoms like severe diarrhea ,abdominal pain , stomach uncomfortable and other. The aim of this current study to see how ellagic acid act to Attenuates 5-FU-Induced Intestinal Mucositis and Diarrhea in Mice . we induced the intestinal mucositis by injected the mice intraperitoneally in 5-fluorouracil about 50mg per kg daily for four days respectively and then assessment the IM by measurement the level of some antioxidant enzymes like SOD , and level of some pro-inflammatory cytokines (IL-6) and lipid peroxidation biomarker (MDA) and we note the difference in the histopathological scoring after administration the ellagic acid to the mice in two different dose (10mg and 5mg per kg) daily for ten days respectively and before the fluorouracil injection in one hour .pretreatment with ellagic acid specialized dose of 10mg per kg significant improvement in the level of antioxidant enzymes ,pro inflammatory cytokines ,lipid peroxidation biomarker and histopathologicaL score compared with 5-FU group, moreover the potential action of ellagic acid was further supported by histopathological examination. all these data suggest that the ellagic acid effective in protective from 5-FU-induced intestinal mucositis.
Effectiveness of Myoinositol alone or in Companion with Metformin in Improving Hormonal, Metabolic, and Clinical Features of PCOS Women
Authors: Alnisani Zainab Abdulhameed , Manal Khalid Abdulrida  
Published: November 2023

Polycystic ovary syndrome (PCOS) referring to a syndrome that is recognized as a life-course disease and has both metabolic and reproductive signs; main pathophysiological cause includes insulin resistance, hyperandrogenism, and oxidative stress state. The study aimed to assess the impact of combining Myoinositol and Metformin, the main insulin-sensitizing drugs, on improving clinical, metabolic, and hormonal parameters in females with PCOS. A clinical trial that was prospective, randomized, and comparative on 54 patients (aged 18-40 y) are divided into three groups: group1 patients allocated to receive Myo-inositol(4g), group2 patients assigned to receive Metformin(1g) and group3 patients assigned to receive Myo-inositol(4g) + Metformin(1g) all for three months. Baseline and post-intervention fasting blood samples were collected to evaluate hormonal, metabolic parameters, and oxidative stress biomarkers. Metformin and Myoinositol together lead to a significant drop free testosterone (P = 0.002), LH (P 0.003), LH to FSH ratio(P=0.004), FSI (P 0.012), the HOMA IR (p 0.019), hirsutism score (p=<0.001) and acne score (p= 0.003), besides substantial increase in GPX (P 0.02). Meanwhile, Myoinositol supplement causes a substantial drop in free testosterone (p=0.013), FSI (P 0.02), and HOMA – IR (P value=0.025) also a substantial rise in GPX (P=0.005). Combining Myoinositol with metformin results in improving clinical, metabolic, hormonal parameters, as well as oxidative indicators for PCOS females.
Publication patterns of posters and oral presentations at the Annual Meeting of the Joint AANS/CNS Cerebrovascular Section
Authors: Brown Nolan J. , Mehkri Yusuf , Hartke Joelle N. , Chakravarti Sachiv , Gendreau Julian , Catapano Joshua S. , Lawton Michael T. 
Published: November 2023

OBJECTIVE
The American Association of Neurological Surgeons (AANS) and Congress of Neurological Surgeons (CNS) Joint Cerebrovascular (CV) Section serves as a centralized entity for the dissemination of information related to CV neurosurgery. The quality of scientific conferences, such as the CV Section’s Society of NeuroInterventional Surgery Annual Meeting, can be gauged by the number of poster and oral presentations that are published in peer-reviewed journals. However, publication rates from the CV Section’s meetings are unknown. The objective of this study was to assess the rate at which abstracts presented at the AANS/CNS CV Section Annual Meeting from 2014 to 2018 were subsequently published in peer-reviewed journals.

METHODS
The abstract titles for all accepted poster and oral podium presentation abstracts from the 2014–2018 Annual Joint AANS/CNS CV Section Meetings were searched using PubMed. A match was defined as sufficient similarity between the abstract and its corresponding journal publication with regard to title, authors, methods, and results. Five-year impact factors (IFs) from Journal Citation Reports (JCR), the country of the corresponding author, and the number of citations in the Scopus database were obtained using the articles’ digital object identifier when available, or the exact article title, journal, and year of publication.

RESULTS
Of the 607 total poster and oral presentations from the 2014–2018 Annual Meetings of the AANS/CNS Joint CV Section, 46.29% (n = 281) have been published. Published articles received 3233 total citations for an average number of citations per article (± SD) of 10.89 ± 16.37. The average 5-year JCR IF of published studies was 4.64 ± 3.13. Additionally, 98.22% of published abstracts were in publication within 4 years from the time the abstract was presented. The most common peer-reviewed neurosurgical journals featuring these publications were the Journal of Neurosurgery, World Neurosurgery, the Journal of NeuroInterventional Surgery, Neurosurgery, and the Journal of Clinical Neuroscience.

CONCLUSIONS
Nearly half of all poster and oral presentations at the annual meetings of the AANS/CNS Joint CV Section from 2014 to 2018 have been published in PubMed-indexed, peer-reviewed journals. The average number of citations per publication (10.89 ± 16.37) reflects the high quality of abstracts accepted for presentation. It is important to continuously assess the quality of research presented at national conferences to ensure that standards are being maintained for the advancement of clinical practice in a given area of medicine. Conference abstract publication rates in peer-reviewed journals represent a way in which research quality can be gauged, and the authors encourage others to conduct similar investigations in their subspecialty area of interest and/or practice.
Impact of target depth on safety and efficacy outcomes in MR-guided focused ultrasound thalamotomy for tremor patients
Authors: Büchele Fabian , Mahendran Sujitha , Uhl Mechtild , Freudinger Carola , Maric Angelina , Heeb Nicole Sarangi , Oertel Markus Florian , Baumann Christian Rainer , Stieglitz Lennart Henning 
Published: November 2023

OBJECTIVE
Target depth, defined by the z-coordinate in the dorsoventral axis relative to the anterior commissure–posterior commissure axial plane of the MR-guided focused ultrasound (MRgFUS) lesion, is considered to be critical for tremor improvement and the occurrence of side effects such as gait impairment. However, although different z-coordinates are used in the literature, there are no comparative studies available with information on optimal lesion placement. This study aimed to compare two different MRgFUS lesion targets (z = +2 mm vs z = 0 mm) regarding efficacy and safety outcomes.

METHODS
The authors conducted a retrospective analysis of 52 patients with pharmacoresistant tremor disorders who received unilateral MRgFUS thalamotomy in the ventral intermediate nucleus for the first time between 2017 and 2022 by one neurosurgeon, with two different z-coordinates, either z = +2 mm (+2-mm group; n = 17) or z = 0 mm (0-mm group; n = 35), but otherwise identical parameters. Standardized video-recorded assessments of efficacy (including the Washington Heights-Inwood Genetic Study of Essential Tremor scale) and safety (using a standardized grading system) outcomes at baseline and at 6 months posttreatment were reviewed and compared. Moreover, overall patient satisfaction was extracted as documented by the examiner at 6 months.

RESULTS
Based on a multiple logistic regression analysis, the authors found that a more dorsal target with a z-coordinate of +2 mm as compared with 0 mm was associated with a higher incidence of any persistent side effect at 6 months (p = 0.02). Most consistently, sensory disturbances, although mild and nondisturbing in most cases, occurred more frequently in the +2-mm group (35% vs 11%, p = 0.007), while no significant differences were found for gait impairment (29% vs 35%) and arm ataxia (24% vs 11%). On the other hand, average tremor suppression was similar (63.6% vs 60.2%) between the groups. Here, higher efficacy was associated with a higher side effect burden in the 0-mm group but not in the +2-mm group. Despite the occurrence of side effects, general patient satisfaction was high (87% would undergo MRgFUS again) as most patients valued tremor suppression more.

CONCLUSIONS
A more ventral MRgFUS target of z = 0 mm seems to be associated with a more favorable safety and a comparable efficacy profile as compared with a more dorsal target of z = +2 mm, but prospective studies are warranted.
Laser interstitial thermal therapy compared with open resection for treating subependymal giant cell astrocytoma
Authors: Aum Diane J. , Reynolds Rebecca A. , McEvoy Sean D. , Wong Michael , Roland Jarod L. , Smyth Matthew D. 
Published: November 2023

OBJECTIVE
Subependymal giant cell astrocytomas (SEGAs) are WHO grade 1 tumors associated with tuberous sclerosis that classically arise from the ventricular wall near the caudate groove and foramen of Monro. Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique, which works by heating a stereotactically placed laser fiber to ablative temperatures under MRI thermometry monitoring. In this paper, the authors present LITT as a surgical alternative to open resection of SEGAs.

METHODS
Twelve patients with SEGAs who underwent 16 procedures between 2007 and 2022 at a single institution were retrospectively reviewed. These patients underwent either open resection or LITT. Clinical data, imaging, recurrence rate, further treatments, and related complications were analyzed.

RESULTS
Among the 16 procedures, 9 were open resection and 7 were LITT. An external ventricular drain was placed in 66% (6/9) of open procedures and 57.1% (4/7) of LITT cases. A septostomy was performed in 56% (5/9) of open procedures and 29% (2/7) of LITT cases. Complication rates were higher in open cases than in LITT procedures (44% vs 0%, p < 0.05). Complications included hydrocephalus, transient venous ischemia, wound infection, and bone flap migration. The median length of hospital stay was 4 days (IQR 3.3–5.5 days) for open cases and 4 days (IQR 3.0–7.0 days) for LITT procedures. Recurrence or progression occurred after 3 open cases and 2 LITT cases (33% vs 33%, p = 0.803). For the recurrences, 2 open cases underwent stereotactic radiosurgery, 1 open case underwent LITT, and 1 LITT case underwent repeat LITT. Among the LITT cases, only the patients with no decrease in tumor size by 6 months experienced tumor progression afterward. The 2 LITT cases with progression were the only ones with calcification present on preoperative imaging. The median follow-up times for cases assessed for progression were 8.4 years (IQR 3.8–14.4 years) for open resection and 3.9 years (IQR 3.4–5.1 years) for LITT.

CONCLUSIONS
The small size of this case series limits generalizability or adequate comparison of safety. However, this series adds to the literature supporting LITT as a less invasive surgical alternative to open resection of SEGAs and demonstrates that LITT has similar recurrence and/or progression rates to open resection. Additional studies with more data are necessary for comprehensive comparisons between open resection and LITT for treating SEGA.
An online calculator using machine learning for predicting survival in pediatric patients with medulloblastoma
Authors: Kuo Cathleen C. , Monteiro Andre , Lim Jaims , Brown Nolan J. , Recker Matthew J. , Ghannam Moleca M. , Gendreau Julian L. , Li Veetai , Reynolds Renée M. 
Published: November 2023

OBJECTIVE
Medulloblastoma is the most common malignant intracranial tumor affecting the pediatric population. Despite advancements in multimodal treatment over the past 2 decades yielding a 5-year survival rate > 75%, children who survive often have substantial neurological and cognitive sequelae. The authors aimed to identify risk factors and develop a clinically friendly online calculator for prognostic estimation in pediatric patients with medulloblastoma.

METHODS
Pediatric patients with a histopathologically confirmed medulloblastoma were extracted from the Surveillance, Epidemiology, and End Results database (2000–2018) and split into training and validation cohorts in an 80:20 ratio. The Cox proportional hazards model was used to identify the univariate and multivariate survival predictors. Subsequently, a calculator with those factors was developed to predict 2-, 5-, and 10-year overall survival as well as median survival months for pediatric patients with medulloblastoma. The performance of the calculator was determined by discrimination and calibration.

RESULTS
One thousand seven hundred fifty-nine pediatric patients with medulloblastoma met the prespecified inclusion criteria. Age, sex, race, ethnicity, median household income, county attribute, laterality, anatomical location, tumor grade, tumor size, surgery status, radiotherapy, and chemotherapy were variables included in the calculator (https://spine.shinyapps.io/Peds_medullo/). The concordance index was 0.769 in the training cohort and 0.755 in the validation cohort, denoting clinically useful predictive accuracy. Good agreement between the predicted and observed outcomes was demonstrated by the calibration plots.

CONCLUSIONS
An easy-to-use prognostic calculator for a large cohort of pediatric patients with medulloblastoma was established. Future efforts should focus on improving granularity of population-based registries and externally validating the proposed calculator.
Molecular detection of Human Papillomavirus genotype-16&-18 in tissues from patients with prostate cancer and benign prostatic hyperplasia
Authors: AL-Mahbobi Taghreed F. , Mohammed Ali Saad H. , AL- Kurtas Mohammed A. 
Published: November 2023

Background: High oncogenic-risk genotypes of human Papillomavirus (HPV) infect a wide range of human cells, including prostate tissue that give rise to benign prostatic hyperplasia and prostatic adenocarcinomas.Objectives: This study aimed to detect DNA of HPV genotype-16 &18 using in situ hybridization technique in prostatic tissues from benign prostatic hyperplasia and prostatic adenocarcinomas, and elucidate the association between these HPV genotypes and prostatic carcinogenesis.Patients and methods: Forty-eight (48) formalin-fixed, paraffin embedded prostatic tissue blocks were obtained ,among them (28) tissue biopsies from prostatic carcinoma with different grades and (20) benign prostate hyperplastic tissue blocks as well as (10) apparently normal prostate tissue autopsies which were collected from the archives of Forensic Medicine Institute / Baghdad and used as prostate healthy control groups. Detection and genotyping of HPV was done by highly sensitive in situhybridization technique.Results: The signals of in situ hybridization reactions of both HPV-16 and HPV-18 in prostate cancer cases in the present study was 25% (7 / 28) whereas in BPH, HPV-16 was detected in 45 %( 9 /20) and HPV-18 was presented in 35 %( 7/ 20). Neither HPV-16 nor HPV-18 was detected in the apparently healthy control group.The percentages of HPV 16 and HPV18 were increasing with advancing of grade of prostate cancer.Conclusion: Our results indicate that the oncogenic HPV-16 might contribute to the development of subset of prostate tumors. In addition, HPV16&18 might have a crucial role in progression of the prostate cancer and benign prostatic hyperplasia
Role of Salivary Tumor Necrosis Factor-alpha and Immunoglobulin- A in Recurrent Aphthous Stomatitis
Authors: Al-Ghurabei Batool H 
Published: November 2023

Background: Until today, the etiology of recurrent aphthous stomatitis (RAS) remains unknown, although hints of its etiologic basis lay on genetic susceptibility, infectious agents and alterations in immune mechanics.Objectives: The aim of this study was to investigate the possible alterations in salivary tumor necrosis factor-alpha (TNF-α) and Immunoglobulin-A (IgA) level in patients with RAS and its relation with clinical types of disease.Subjects and Methods: Salivary TNF-α levels were investigated in 50 RAS patients and 25 healthy controls by enzyme-linked immunosorbent assay (ELISA). Single radial immune diffusion method was used for estimation of IgA level in two studied groups.Results: Salivary level of TNF-α was significantly higher in RAS patients than in healthy controls (p<0.001), Moreover, the level of TNF-α was significantly increased in minor type of disease than in major and herptiform types (p<0.05). On the other hand, the level of IgA showed no significant differences between patients and healthy controls and neither among clinical types of disease (p>0.05).Conclusion: These findings suggest that saliva provides an ideal medium for the detection of proinflammatory markers of the oral cavity, moreover; salivary TNF-α may play an important role in pathogenesis of this disease and it may also have an important role in the search of new treatments for this disease. As well as these results indicated to a possible role of mucosal immune system in pathogenesis of RAS.
Methodological guidelines on supporting databases of terminological dictionaries as the case study of RNPLS&T’s System of Electronic Dictionaries
Authors: Zaitseva E. M. , Smirnov Yu. V. 
Published: November 2023

Within the framework of developing fundamental scientific discipline “e-librarianship”, the RNPLS&T designs its electronic terminological dictionaries. The authors describe the System of Electronic Dictionaries being developed by the Russian National Public Library for Science and Technology. For today, the System comprises subject terminological dictionaries and dictionaries of abbreviations, i. e. “Electronic terminological dictionary on SIBID”, “Union terminological dictionary in e-librarianship”, “Information technologies in education:The electronic terminological dictionary”, and “Electronic dictionary of standardized abbreviations in the Russian and 25 foreign European languages for bibliographic records”. The goal is to organize and systematize the terminology in the library and information sciences and related disciplines, which is especially important in the period of intensive development of e-librarianship as a fundamental scientific discipline. The practical significance of these electronic dictionaries is evidenced by the statistics of page traffic at RNPLS&T website where the dictionaries are accessible for free loading and further use. The characteristics and design principles of the subject terminological dictionaries are analyzed; the software designed at RNPLS&T for building them is described. The focus is made on methodological guidelines on how to manage the databases of subject terminological dictionaries.
The Twenty Sixth International Conference “Information technologies, computer systems and publications for libraries” (“LIBCOM–2022”): The review of events
Authors: Shrayberg Ya. L. , Kulikova A. A. 
Published: November 2023

The Twenty Sixth International Conference “Information technologies, computer systems and publications for libraries” (“LIBCOM–2022”) held on November 20-25, 2022, is reviewed. The key topics are covered, namely, the status of and prospects for modern information, computer and Internet-technologies in library services, in universities and research organizations, educational technologies, legal aspects in the work of libraries and information producers, e-libraries and digital information resources, etc. The authors focus on several events, i. e. the Seventh Industrial Conference “Book publishing and the libraries: Vectors of interaction”, scientific and practical conference of the National Library Association: Libraries of the Future: (NALF), the scientific conference “Scientometrics and bibliometrics in the modern educational environment: The role of libraries”, scientific and educational symposium “University and academic libraries to support educational process in the modern digital environment”, central discussion site “On the way to the new national system of sci-tech information”, presentation of the two-volume publication “Twenty annual reports to the Crimea International Forum” and the publication “Y. L. Shrayberg. The biobibliography”, expert panel “How to bring up inventors and researcher? The role of modern library. New approaches and technologies”, and the 2022 fall session of the permanent IRBIS School “Using and upgrading LIS IRBIS”. The conclusions on the Conference work are made.
The role of Aliajhdar Seyidzade (1899–1970), a library scientist, bibliographer and literature scholar, in developing librarianship in Azerbaijan
Authors: Ismailov N. I. , Kazimi P. F. , Yusifova G. Yu. 
Published: November 2023

The political, economic and cultural aspects of the Soviet era heritage, best pieces of culture, literature, applied and fine arts make the universal human values that bring people together and unite them. We have to study and appreciate the work, role and merits of individuals who play an important role in building and developing cultural environment.Aliajhdar Seyidzade was a progressive intellectual who devoted his life to culture, book and reading popularization, libraries, and extending literary ties in the hard periods during the Soviet era.The authors investigate into Seiydzade’s versatile cultural activities. He lived an interesting life, and being government official himself, did not abandon the national concept and values within the Soviet ideological system. His works, his thoughts and efforts reflect the breadth of his knowledge and widest view of the world. His attitude: “Not in all cases propaganda is an ideology, propaganda must be progressive...” is especially noteworthy.
Organisational Commitment and Turnover Intentions: Does Self-Efficacy Matter?
Authors: Opolot Julius Samuel , Lagat Charles , Kipsang Stanley 
Published: November 2023

Purpose- This paper examined the relationship between organisational commitment, self-efficacy, and turnover intentions among academic staff in universities in Uganda, a developing nation.Design/Methodology- This research was undertaken via a cross-sectional research design to test the hypotheses using quantitative data collected from 574 academic staff at selected universities in Uganda. Hayes’s PROCESS macro (Version 4.2) was used to carry out a moderation analysis. Findings- The results indicate that interaction between self-efficacy and organisational commitment enhanced turnover intention. Academic staff with high levels of commitment, are less likely to engage in turnover behaviour at high levels of self-efficacy. Practical Implications- Drawing on empirical evidence, university managers seeking to improve staff retention need to adopt strategies that boost self-efficacy in order to instantly support organisational commitment. Adoption of participative work culture, equity, training, teamwork, and inclusiveness is an important signal and source of social information that the university values its employees and their stay.