bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aeromonas hydrophila infection in acute myeloid leukemia: A case report
Authors: He Rui , Zhong Siqi , Fan Jinghua 
Published: October 2023

Rationale:

Aeromonas hydrophila, a bacterium commonly found in a variety of soils, aquatic habitats, and other natural environments, is known for causing infections and hemorrhagic diseases in both aquatic and terrestrial animals. Patients with leukemia, when infected by Aeromonas hydrophila following chemotherapy, face an increased risk of developing necrotizing fasciitis.

Patient concerns:
A 48-year-old male with a history of acute myeloid leukemia presented with swelling and pain in his right hand after being stabbed by a grass carp two days ago. The injury occurred on the fifth day after his last chemotherapy session when he was accidentally punctured in the right thumb and ring finger by a carp while fishing. Two days following the injury, the skin isurrounding the wound turned black immediately, while the rest of his hand was reddened, swollen, and bleeding.

Diagnosis:

Aeromonas hydrophila infection in the soft tissue of the right hand.

Interventions:
Intravenous antibiotics and local debridement.

Outcomes:
The patient experienced an alleviation of systemic poisoning symptoms, effective control of the local wound infection.

Lessons:
It is important for physicians to appreciate the potential for highly unusual and life-threatening infections in patients with acute myeloid leukemia. Early diagnosis and prompt treatment can prevent the development of necrotizing fasciitis and save patients' lives.
Surgical Rehabilitation of a Continuous Orbital and Maxillary Defect from Rhino-Orbital Mucormycosis Utilising Digital Technology - A Case Report
Authors: Rathee Manu , Chahal Sujata , Alam Maqbul , Singh Sandeep , Divakar S. 
Published: October 2023

AbstractRationale:COVID-19 has led to a resurgence in cases of mucormycosis, especially the rhino-orbital form affecting the oral cavity, nasal, orbital and cerebral regions.Patient Concerns:The surgical treatment in this patient led to the exenteration of orbital contents and segmental maxillectomy of the affected side leading to facial disfigurement and inability to masticate.Diagnosis:A combined mucormycosis-associated oro-orbital defect was present leading to a communication between oral and orbital cavities.Treatment:Rehabilitation utilising digital technology for removable prosthesis was planned for the combined orbital and oral defect.Outcomes:The independent intraoral and orbital prosthesis reduced the mobility of the orbital prosthesis while performing functional movements. The advancements in digital technology led to the convenient and resilient fabrication of prostheses for large facial defects.Take-away Lessons:The prosthetic rehabilitation of a continuous orbital and oral defect with a hybrid of both digital and conventional means provided an aesthetic, feasible and financially sound solution to the patient.
Cost-effectiveness of the Flapless Insertion of Zygomatic Implants Using Dynamic Navigation - A Retrospective Study
Authors: Bhalerao Ashwini , Ayoub Ashraf , Marimuthu Madhulaxmi , Wahab Abdul , Kumar Vaibhav 
Published: October 2023

Abstract

Introduction:
Zygomatic implants are an effective solution for rehabilitation of edentulous atrophic maxillae. However, the conventional technique of zygomatic implant placement is invasive, requires a longer healing period and is economically cumbersome. Therefore, the flapless technique of insertion of zygomatic implants using dynamic navigation system has been introduced. This study aims to compare the cost-effectiveness of flapless insertion of zygomatic implants using dynamic navigation to the conventional flap technique.

Materials and Methods:
The study participants were divided into two groups: Group A (n = 20) included patients treated by flapless insertion of zygomatic implants using dynamic navigation and Group B (n = 20) included patients treated with zygomatic implants using the flap technique. An analysis of the effectiveness of the implants was done using the concept of quality-adjusted prosthesis years, and an analysis of the costs was done by evaluating the treatment costs at each step. The data were collected, and analysis was done using IBM SPSS software. The Kruskal–Wallis rank-sum test was employed to analyse variations in costs and effects between the two groups.

Results:
The study showed that the distribution of costs varies across both the categories of the procedure. Group B shows lesser cost-effectiveness as compared to Group A.

Conclusion:
The technique of flapless insertion of zygomatic implants is cost-effective. However, further studies considering factors such as time and cost of productivity evaluating the cost-effectiveness should be conducted.
Clinicopathological analysis of mesenchymal hamartoma of the liver
Authors: Liao Guangjie 
Published: October 2023

Abstract:
To improve the awareness of the CT appearances and histopathological presentations of mesenchymal hamartoma of the liver (MHL),one case of MHL was observed and analyzed its imaging and pathological features with review of the literatures. One case of MHL was observed and analyzed its imaging and pathological features with a review of the literature. This patient underwent an operation and the tumor was completely resected. A diagnosis of MHL was established by pathological examination. No tumor recurrence or metastasis was observed 4 years after operation. MHL is a rare benign tumor of the liver. Preoperative diagnosis is very significant. As its main imaging method, CT scan has some specific features. The management of MHL remains controversial. To achieve a good long-term outcome, complete resection of MHL is recommended.
Role of Novel Glucagon-like Peptide-1 Receptor Analogue Polyethylene Glycol Loxenatide in Type 2 Diabetes: A Systematic Review and Meta-analysis
Authors: Dutta Deep , Chatterjee Subhankar , Datta Priyankar K. , Mohindra Ritin , Sharma Meha 
Published: October 2023

Abstract

Background:
Polyethylene glycol loxenatide (peg-loxenatide) is a novel glucagon-like peptide-1 receptor agonist developed and available for clinical use in China. This meta-analysis was performed as no meta-analysis has analysed the efficacy and safety of peg-loxenatide in type 2 diabetes (T2DM).

Methods:
Electronic databases were systematically reviewed for RCTs having patients living with T2DM receiving peg-loxenatide in treatment arm and placebo/any other diabetes medicine in control arm. The primary outcome was to evaluate changes in glycated haemoglobin. The secondary outcomes were to evaluate alterations in weight, blood pressure, fasting glucose, prandial glucose, lipids, and adverse events.

Results:
Data from four trials (718 patients) were analysed. Over 12–24 weeks of clinical use, HbA1c was significantly lower in patients receiving standard-dose peg-loxenatide (100 mcg/week) {MD -0.95% [95% confidence interval (CI): -1.19 to -0.71]; P < 0.01; I2 = 76%} and high-dose peg-loxenatide (200 mcg/week) [MD -1.15% (95% CI: -1.47 to -0.82); P < 0.01; I2 = 90%], as compared to placebo. Standard-dose peg-loxenatide was not associated with increased occurrence of nausea [RR 2.87 (95% CI: 0.56 to 14.72); P = 0.21; I2 = 10%], vomiting [RR 4.73 (95% CI: 0.53 to 41.88); P = 0.16; I2 = 0%], and anorexia [RR 0.78 (95% CI: 0.18 to 3.28); P = 0.73; I2 = 0%]. Occurrence of nausea [RR 16.85 (95% CI: 3.89 to 72.92); P < 0.01; I2 = 10%], vomiting [RR 15.90 (95% CI: 2.99 to 84.55); P < 0.01; I2 = 0%], and anorexia [RR 3.85 (95% CI: 1.24 to 11.88); P = 0.02; I2 = 0%] was significantly higher with high-dose peg-loxenatide, as compared to placebo.

Conclusion:
Peg-loxenatide (100 mcg/week) is the most appropriate dose for clinical use as it is associated with good glycaemic efficacy with minimal gastro-intestinal side effects.
South Asian Endocrinology: Challenges and Concerns, Collaboration and Consolidation
Authors: Bhattacharya Saptarshi , Kalra Sanjay 
Published: October 2023

Abstract
The practice of endocrinology in South Asia poses many challenges but simultaneously offers unique opportunities. The population in this region is predisposed to diabetes and cardiovascular disease at a much lower body mass index compared to Caucasians. Dietary deficiencies, higher prevalence of infection and distinct environmental and genetic factors further complicate the presentation of endocrine disorders. Over the past few decades, important breakthroughs have been made to confront these challenges. Collaboration among the endocrine fraternity of the South Asian countries will help to consolidate these gains and pave the way forward for a healthier region.
The Impact of a Collaborative Care Model on Health Trajectories among Patients with Co–Morbid Depression and Diabetes: The INDEPENDENT Study
Authors: Balasundaram Bhavani Sundari , Mohan Anjana Ranjit , Subramani Poongothai , Ulagamathesan Venkatesan , Tandon Nikhil , Sridhar Gumpeny Ramachandra , Sosale Aravind Ramachandra , Shankar Radha , Sagar Rajesh , Rao Deepa , Chwastiak Lydia , Mohan Viswanathan , Ali Mohammed Kumail , Patel Shivani Anil 
Published: October 2023

Abstract

Context:
Collaborative care models for depression have been successful in a variety of settings, but their success may differ by patient engagement. We conducted a post-hoc analysis of the INDEPENDENT trial to investigate the role of differential engagement of participants on health outcomes over 3 years.

Settings and Design:
INDEPENDENT study was a parallel, single-blinded, randomised clinical trial conducted at four socio-economically diverse clinics in India. Participants were randomised to receive either active collaborative care or usual care for 12 months and followed up for 24 months.

Method:
We grouped intervention participants by engagement, defined as moderate (≤7 visits) or high, (8 or more visits) and compared them with usual care participants. Improvements in composite measure (depressive symptoms and at least one of three cardio-metabolic) were the primary outcome.

Statistical Analysis:
Mean levels of depression and cardio-metabolic measures were analysed over time using computer package IBM SPSS Statistics 25.

Results:
The composite outcome was sustained the highest in the moderate engagers [27.5%, 95% confidence interval (CI): 19.5, 36.7] and the lowest in high engagers (15.8%, 95% CI: 8.1, 26.8). This pattern was observed for individual parameters – depressive symptoms and glycosylated haemoglobin. Progressive reductions in mean depressive symptom scores were observed for moderate engagers and usual care group from baseline to 36 months. However, in high engagers of collaborative care, mean depressive symptoms were higher at 36 months compared to 12 months.

Conclusion:
Sustained benefits of collaborative care were larger in participants with moderate engagement compared with high engagement, although a majority of participants relapsed on one or more outcome measures by 36 months. High engagers of collaborative care for co-morbid depression and diabetes may need light touch interventions for longer periods to maintain health and reduce depressive symptoms.
MicroRNA Molecular Profiling Reveals Increase Expression of hsa-miR-186-5p, hsa-miR-320a-3p, and hsa-miR-486-5p With Storage Time in Packed Blood Cells
Authors: Fararjeh AbdulFattah , AL-Sanabra Ola M. , Ghalyoun Ammar Abu , Al-Amro Raghad , Khater Suhaib , Bzour Jameel 
Published: October 2023

BACKGROUND:
Compared to other blood cells, adult red blood cells have a higher concentration of microRNAs (miRNAs). The effectiveness of preserved blood cells following transfusion is affected by a variety of factors, like changes in miRNA levels. One day, these small RNAs might help determine the efficacy and safety of blood products.

AIMS:
This study sought to identify the miRNA present in both fresh blood and stored blood because there is growing evidence that these cells are enriched with miRNAs.

MATERIALS AND METHODS:
Blood samples were taken from three healthy donors to detect the expression of miRNAs using illumina platform for RNA sequencing. Total RNA was isolated from stored units at 0, 14, 21, and 28 days, respectively. Bioinformatics analysis has been carried out to analyze the miRNAs.

RESULTS:
The majority of miRNA expression was decreased in time-dependent manner, particularly after day 14 of packed blood cells (PBCs) storage such as hsa-miR-20a-5p, hsa-miR-17-5p, and hsa-miR-423-3p. While other miRNAs such as hsa-miR-320a-3p, hsa-miR-186-5p, and hsa-miR-486-5p, showed a significant re-upregulated after day 21.

CONCLUSION:
In summary, the PBCs at days 14 and 21 had the lowest levels of miRNAs, which may indicate less of a relationship with storage lesions. However, older PBCs displayed significant levels of miRNAs, which could indicate storage lesions or cause a number of clinical issues for the recipients.
Health impacting behaviour & morbidity: Implications for adolescent & youth health programmes in India
Authors: Banandur Pradeep , Gopalkrishna Gururaj , Rizvi Zoya , Beri Gopal 
Published: October 2023

Background & objectives:
In Himachal Pradesh (HP), a comprehensive health survey was conducted to assess the prevalent health affecting habits and issues among young individuals aged 10 to 24 yr. The study was aimed to evaluate key factors such as nutrition, substance use (including tobacco and alcohol), mental health concerns such as anxiety and depression, sexual behaviours and personal hygiene, as well as incidents of violence and injury (including road traffic and other injuries).

Methods:
A cross-sectional survey was conducted in HP on 2895 individuals aged between 10 and 24 yr. The survey encompassed four districts, namely Shimla, Kinnaur, Kangra, and Sirmaur, and 12 blocks (three in each district). To ensure a representative sample, a stratified multistage cluster sampling approach was used. Districts and blocks were selected purposively so as to represent the diverse sociodemographic and cultural characteristics of this region. Within each block, thirty clusters were chosen using a probability proportional to size method. Clusters were defined as villages in rural areas and wards in urban areas. The World Health Organization 30 × 7 cluster technique was employed to identify households and individuals for the study.

Results:
Underweight (44.39%), risk of cell phone addiction (19.62%), feeling anxious (15.54%), unintentional injuries (14.72%) and violence (8.19%) were the top five health impacting problems among young people in HP.

Interpretation & conclusions:
The leading health impacting problems identified are preventable and/or modifiable factors affecting the overall health and development of young people in HP. These need to be addressed as priority health problems for interventions with a focus on maintaining positive health through integrated approaches including care provision, risk reduction and health promotion related to these health impacting behaviours. Such interventions are likely to yield better results towards the overall health and development of young people in HP.
High-quality Agar and Polyacrylamide Tumor-mimicking Phantom Models for Magnetic Resonance-guided Focused Ultrasound Applications
Authors: Sofokleous Panagiotis , Damianou Christakis 
Published: October 2023

Background:
Tissue-mimicking phantoms (TMPs) have been used extensively in clinical and nonclinical settings to simulate the thermal effects of focus ultrasound (FUS) technology in real tissue or organs. With recent technological developments in the FUS technology and its monitoring/guided techniques such as ultrasound-guided FUS and magnetic resonance-guided FUS (MRgFUS) the need for TMPs are more important than ever to ensure the safety of the patients before being treated with FUS for a variety of diseases (e.g., cancer or neurological). The purpose of this study was to prepare a tumor-mimicking phantom (TUMP) model that can simulate competently a tumor that is surrounded by healthy tissue.

Methods:
The TUMP models were prepared using polyacrylamide (PAA) and agar solutions enriched with MR contrast agents (silicon dioxide and glycerol), and the thermosensitive component bovine serum albumin (BSA) that can alter its physical properties once thermal change is detected, therefore offering real-time visualization of the applied FUS ablation in the TUMPs models. To establish if these TUMPs are good candidates to be used in thermoablation, their thermal properties were characterized with a custom-made FUS system in the laboratory and a magnetic resonance imaging (MRI) setup with MR-thermometry. The BSA protein’s coagulation temperature was adjusted at 55°C by setting the pH of the PAA solution to 4.5, therefore simulating the necrosis temperature of the tissue.

Results:
The experiments carried out showed that the TUMP models prepared by PAA can change color from transparent to cream-white due to the BSA protein coagulation caused by the thermal stress applied. The TUMP models offered a good MRI contrast between the TMPs and the TUMPs including real-time visualization of the ablation area due to the BSA protein coagulation. Furthermore, the T2-weighted MR images obtained showed a significant change in T2 when the BSA protein is thermally coagulated. MR thermometry maps demonstrated that the suggested TUMP models may successfully imitate a tumor that is present in soft tissue.

Conclusion:
The TUMP models developed in this study have numerous uses in the testing and calibration of FUS equipment including the simulation and validation of thermal therapy treatment plans with FUS or MRgFUS in oncology applications.
Ultrawideband coupled relative positioning algorithm applicable to flight controller for multidrone collaboration
Authors: Yang Jeonggi , Lee Soojeon 
Published: October 2023

AbstractIn this study, we introduce a loosely coupled relative position estimation method that utilizes a decentralized ultrawideband (UWB), Global Navigation Support System and inertial navigation system for flight controllers (FCs). Key obstacles to multidrone collaboration include relative position errors and the absence of communication devices. To address this, we provide an extended Kalman filter‐based algorithm and module that correct distance errors by fusing UWB data acquired through random communications. Via simulations, we confirm the feasibility of the algorithm and verify its distance error correction performance according to the amount of communications. Real‐world tests confirm the algorithm's effectiveness on FCs and the potential for multidrone collaboration in real environments. This method can be used to correct relative multidrone positions during collaborative transportation and simultaneous localization and mapping applications.
Cytokine and Chemokine Profiles in Acute Severe Fever with Thrombocytopenia Syndrome and Scrub Typhus in South Korea
Authors: Kwon Ji-Soo , Hong Sun In , Kim Ji Yeun , Cha Hye Hee , Kim Taeeun , Park Se Yoon , Kim Min-Chul , Park Seong Yeon , Choi Seong-Ho , Chung Jin-Won , Kim Sung-Han 
Published: October 2023

ABSTRACT.
In East Asia, severe fever with thrombocytopenia syndrome (SFTS) and scrub typhus, which are common endemic tick- and mite-mediated diseases sharing common clinical manifestations, are becoming public health concerns. However, there are limited data on the comparative immunopathogenesis between the two diseases. We compared the cytokine profiles of SFTS and scrub typhus to further elucidate immune responses that occur during the disease courses. We prospectively enrolled 44 patients with confirmed SFTS and 49 patients with scrub typhus from July 2015 to December 2020. In addition, 10 healthy volunteers were enrolled as healthy controls. A cytometric bead array was used to analyze plasma samples for 16 cytokines. A total of 68 plasma samples, including 31 (45.6%) from patients with SFTS and 37 (54.4%) from patients with scrub typhus, were available for cytokine measurement. There were three cytokine expression patterns: increased levels in both SFTS and scrub typhus (interleukin 6 [IL-6], IL-10, interferon gamma induced protein 10 [IP-10], and granulocyte-macrophage colony-stimulating factor [GM-CSF]), highest levels in SFTS (interferon alpha [IFN-α], IFN-γ, granulocyte-CSF [G-CSF], monocyte chemotactic protein 1 [MCP-1], macrophage inflammatory protein 1α [MIP-1α], and IL-8), and distinct levels in scrub typhus (IL-12p40, tumor necrosis factor alpha [TNFα], IL-1β, regulated on activation and normally T-cell expressed and secreted [RANTES], IL-17A, and vascular endothelial growth factor [VEGF]). Although patients with acute SFTS and scrub typhus exhibited partly shared expression patterns of cytokines related to disease severity, the different profiles of cytokines and chemokines might contribute to higher mortality in SFTS than in scrub typhus. Discrete patterns of helper T cell-related cytokines and VEGF might reflect differences in CD4 T-cell responses and vascular damage between these diseases.
Okul Yöneticilerinin Psikolojik Danışmanlık ve Rehberlik Hizmetlerine Yönelik Tutumları: Farklı Demografik Değişkenler Üzerinden İnceleme
Authors: YILMAZ İsmail , ÖZKAN Metin 
Published: October 2023

Okul Yöneticilerinin Psikolojik Danışmanlık ve Rehberlik Hizmetlerine Yönelik Tutumları: Farklı Demografik Değişkenler Üzerinden İnceleme*
İsmail YILMAZ
Metin ÖZKAN

Öz
Bu araştırmanın amacı, okul yöneticilerinin okul rehberlik ve psikolojik danışmanlık hizmetlerine yönelik tutumlarını belirlemek ve çeşitli değişkenlere göre farklılaşma düzeylerini incelemektir. Nicel araştırma yöntemlerinden tarama modelinin benimsendiği araştırmada, Gaziantep ili Şahinbey ve Şehitkamil ilçelerinde 2022-2023 eğitim öğretim yılında resmi devlet okullarında görev yapan okul yöneticileri çalışma evreni olarak kabul edilmiştir. Araştırma örneklemini ise, bu evren içinden kolay ulaşılabilir örnekleme yöntemiyle seçilmiş 315 gönüllü okul yöneticisi oluşturmuştur. Verilerin toplanmasında, araştırmacı tarafından hazırlanan “Kişisel Bilgi Formu” ve geliştirilen “Okul Yöneticileri Okul Rehberlik ve Psikolojik Danışma Hizmetlerine Yönelik Tutum Ölçeği” kullanılmıştır. Araştırmanın bulguları, okul yöneticilerinin okul PDR hizmetlerine yönelik tutumlarının yüksek düzeyde olumlu olduğunu göstermiştir. Okul yöneticilerinin okul PDR hizmetlerine yönelik tutumlarının cinsiyete göre farklılık gösterdiği ve kadın okul yöneticilerinin, erkek okul yöneticilerine göre okul PDR hizmetlerine yönelik tutumlarının daha olumlu olduğu sonucuna ulaşılmıştır. Okul yöneticilerinin okul PDR hizmetlerine yönelik tutumları öğrenim düzeyi, mesleki kıdem, okul yöneticiliğinde geçirilen hizmet süresi, görev yapılan okul kademesi, okul hizmet alanı ve okulda psikolojik danışman bulunup bulunmamasına göre değişmediği görülmüştür. Araştırma sonuçlarına dayalı olarak; çıkan sonuçların derinlemesine bir araştırma ile irdelenmesine, okul yöneticilerinin okul PDR hizmetlerine yönelik tutumlarının daha farklı değişkenlere bağlı olarak incelenmesine ve okul yöneticilerine okul PDR hizmetleri hakkında uygulamalı eğitimler verilmesine yönelik önerilerde bulunulmuştur.
Anahtar Kelimeler: okul yöneticisi, rehberlik, psikolojik danışma, tutum