bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of manual vacuum-assisted closure technique in wound healing: a case report
Authors: Malini Hema , Ismiati Ismiati , Harahap Wrisma Arif , Oktarina Elvi 
Published: January 2024

Abstract
Background
Diabetic ulcers are complex wounds that require specialized care. Proper wound care is crucial to prevent amputation, and one effective treatment option is negative pressure wound therapy. However, the cost of negative pressure wound therapy can often be a barrier, making it difficult for caregivers and families to access.

Aim
This study aims to develop an alternative system, called the manual vacuum-assisted closure technique, using a 50 cc syringe pump with a pressure value of 93.33 mmHg, to examine the impact of the manual vacuum-assisted closure technique on the continuum of wound status in diabetic ulcers.

Case presentation
A 56-year-old Minangnese man, with a 15-year history of diabetes mellitus and a family history of the disease, presented with a grade IV diabetic ulcer on the dorsal pedis dextra following a postoperative debridement. The wound measured 48 cm2 and had an ankle–brachial index value of 1.0 mmHg. The ulcer originated from being pierced by a nail. Previous treatment involved surgical debridement in early January, followed by twice-daily wound care using gauze and 0.9% NaCl, which showed no improvement. Consequently, the wound worsened and became more painful. The patient also had a history of smoking, which he only quit earlier this year. The wound was assessed using the Bates–Jensen Wound Assessment Tool over a period of 21 days.

Conclusion
After daily manual vacuum-assisted closure technique wound treatment for 21 days in diabetic ulcers, there was a noticeable decrease in the Bates–Jensen Wound Assessment Tool scores. Specifically, on day 5, the score was 38; on day 14, the score was 30; and on day 21, the score was 24. The use of the manual vacuum-assisted closure technique in wound treatment demonstrated significant improvements in diabetic ulcers.
Right ventricular injury in critically ill patients with COVID-19: a descriptive study with standardized echocardiographic follow-up
Authors: Jozwiak Mathieu , Dupuis Claire , Denormandie Pierre , Aurenche Mateu Didac , Louchet Jean , Heme Nathan , Mira Jean-Paul , Doyen Denis , Dellamonica Jean 
Published: January 2024

Abstract
Purpose
Patients with COVID-19 admitted to intensive care unit (ICU) may have right ventricular (RV) injury. The main goal of this study was to investigate the incidence of RV injury and to describe the patient trajectories in terms of RV injury during ICU stay.

Methods
Prospective and bicentric study with standardized transthoracic echocardiographic (TTE) follow-up during ICU stay with a maximum follow-up of 28 days. The different patterns of RV injury were isolated RV dilation, RV dysfunction (tricuspid annular plane systolic excursion < 17 mm and/or systolic tricuspid annular velocity < 9.5 cm/s and/or RV fractional area change < 35%) without RV dilation, RV dysfunction with RV dilation and acute cor pulmonale (ACP, RV dilatation with paradoxical septal motion). The different RV injury patterns were described and their association with Day-28 mortality was investigated.

Results
Of 118 patients with complete echocardiographic follow-up who underwent 393 TTE examinations during ICU stay, 73(62%) had at least one RV injury pattern during one or several TTE examinations: 29(40%) had isolated RV dilation, 39(53%) had RV dysfunction without RV dilation, 10(14%) had RV dysfunction with RV dilation and 2(3%) had ACP. Patients with RV injury were more likely to have cardiovascular risk factors, to be intubated and to receive norepinephrine and had a higher Day-28 mortality rate (27 vs. 7%, p < 0.01). RV injury was isolated in 82% of cases, combined with left ventricular systolic dysfunction in 18% of cases and 10% of patients with RV injury experienced several patterns of RV injury during ICU stay. The number of patients with de novo RV injury decreased over time, no patient developed de novo RV injury after Day-14 regardless of the RV injury pattern and 20(31%) patients without RV injury on ICU admission developed RV injury during ICU stay. Only the combination of RV dysfunction with RV dilation or ACP (aHR = 3.18 95% CI(1.16–8.74), p = 0.03) was associated with Day-28 mortality.

Conclusion
RV injury was frequent in COVID-19 patients, occurred within the first two weeks after ICU admission and was most often isolated. Only the combination of RV dysfunction with RV dilation or ACP could potentially be associated with Day-28 mortality.
Clinical trial registration NCT04335162.
A matrix acting between Fock spaces
Authors: Zhuo Zhengyuan , Li Dongxing , Zeng Tiaoying 
Published: January 2024

AbstractIf $\mathcal{H}_{\nu}=(\nu _{n,k})_{n,k\geq 0}$

H
ν

=

(

ν

n
,
k

)

n
,
k
≥
0

is the matrix with entries $\nu _{n,k}=\int _{[0,\infty )}\frac{ t^{n+k}}{n!}\,d\nu (t)$

ν

n
,
k

=

∫

[
0
,
∞
)

t

n
+
k

n
!

d
ν
(
t
)
, where ν is a nonnegative Borel measure on the interval $[0,\infty )$
[
0
,
∞
)
, the matrix $\mathcal{H}_{\nu}$

H
ν

acts on the space of all entire functions $f(z) =\sum_{n=0}^{\infty} a_{n} z^{n}$
f
(
z
)
=

∑

n
=
0

∞

a
n

z
n

and induces formally the operator in the following way: $$ \mathcal{H}_{\nu}(f) (z)=\sum_{n=0}^{\infty} \Biggl(\sum_{k=0}^{\infty}\nu _{n,k}a_{k}\Biggr)z^{n}. $$

H
ν

(
f
)
(
z
)
=

∑

n
=
0

∞

(

∑

k
=
0

∞

ν

n
,
k

a
k

)

z
n

.
In this paper, for $0< p\leq \infty $
0
<
p
≤
∞
, we classify for which measures the operator $\mathcal{H}_{\nu}(f)$

H
ν

(
f
)
is well defined on $F^{p}$

F
p

and also gets an integral representation, and among them we characterize those for which $\mathcal{H}_{\nu}$

H
ν

is a bounded (resp., compact) operator between $F^{p} $

F
p

and $F^{\infty }$

F
∞

.
Multidisciplinary prehabilitation to improve frailty and functional capacity in high-risk elective surgical patients: a retrospective pilot study
Authors: Wong Henry Man Kin , Qi Ding , Ma Bosco Hon Ming , Hou Pik Yi , Kwong Calvin Ka Woon , Lee Anna ,   Prehab Study Group, Lam Stefanie So Ling , Ting Terry Ho Yan , Ip Kenny Wing Moon , Chan Suet Yi , Tsung Peggy Pui Kee , Chan Albert Kam Ming , Lau Vivian Nga Man , Tang Maria Wing Sze , Ng Kelvin Kwok Chai , Yip Hon Chi , Yee Chi Hang , Joynt Gavin Matthew 
Published: January 2024

Abstract
Background
Frailty is associated with worse outcomes and higher healthcare costs. The long waiting time for surgery is a potential ‘teachable’ moment. We examined the feasibility and safety of a pilot prehabilitation programme on high-risk frail patients undergoing major elective surgery.

Methods
A single-centre, retrospective pilot study (Dec 2020–Nov 2021) on a one-stop prehabilitation programme (structured exercise training, nutritional counselling/therapy, and psychological support) in collaboration with geriatricians and allied health professionals. At least 4 weeks before surgery, patients at high risk of frailty or malnutrition, or undergoing major hepatectomy, esophagectomy, pancreaticoduodenectomy, or radical cystectomy, were referred for prehabilitation (2–3 sessions/week). The primary outcomes were the feasibility and safety of prehabilitation. The secondary outcomes were changes in functional, emotional, and nutritional status and days alive and at home within 30 days after surgery (DAH30) associated with prehabilitation.

Results
Over a 12-month period, 72 out of 111 patients (64.9%) from the Perioperative Medicine Clinic were eligible for prehabilitation, of which 54 (75%) were recruited. The mean (standard deviation) age was 71.9 (6.9) years. The adherence rate to 3 weeks of prehabilitation was high in 52 (96.3%) participants. Prehabilitation improved exercise capacity (P = 0.08), enhanced some functional mobility measures (P = 0.02), and increased nutritional energy (P = 0.04) and protein intakes (P < 0.01). However, prehabilitation-related changes in muscle strength, cognitive function, and emotional resilience were minimal. The median (interquatile range) DAH30 was 19 (14–23) days. No adverse events were reported.

Conclusions
This outpatient-based, one-stop multidisciplinary prehabilitation programme was feasible, safe, and improved several measures of patient’s physiological reserve and functional capacity.

Clinical trial registration
NCT05668221.
Clinical characteristics, treatment course and outcome of adults treated for avoidant/restrictive food intake disorder (ARFID) at a tertiary care eating disorders program
Authors: MacDonald Danielle E. , Liebman Rachel , Trottier Kathryn 
Published: January 2024

Abstract
Background
Avoidant/restrictive food intake disorder (ARFID) is now recognized as a feeding/eating disorder that affects individuals across the lifespan, but research on ARFID in general and particularly in adults remains limited. The purpose of this study was to describe the demographic and clinical characteristics of adults with ARFID seeking treatment at a tertiary care eating disorders program, and to describe the course and outcomes of treatment at three levels of care—inpatient, intensive outpatient, and outpatient individual therapy.

Method
This retrospective chart review study examined the charts of 42 patients who received treatment for ARFID between April 2020 and March 2023. Following diagnostic assessment, patients were referred to either inpatient treatment, intensive outpatient treatment, or outpatient individual therapy. All three levels of care involved individual cognitive behaviour therapy. Inpatients typically transitioned to one of the outpatient treatments as part of a continuous care plan. We examined demographic and clinical characteristics, treatment length and completion, and changes in key indicators during treatment.

Results
Patients were diverse with respect to demographics (e.g., 62% cisgender women; 21% cisgender men; 17% transgender, non-binary, or other gender) and comorbid concerns (e.g., 43% had neurodevelopmental disorders; > 50% had mood and anxiety disorders; 40% had posttraumatic stress disorder [PTSD]; 35% had medical conditions impacting eating/digestion). Most patients presented with more than one ARFID maintaining mechanism (i.e., lack of appetite/interest, sensory sensitivities, and/or fear of aversive consequences of eating). Treatment completion rates and outcomes were good. On average, patients showed significant improvement in impairment related to their eating disorder, and those who were underweight significantly improved on BMI and were not underweight at end of treatment.

Discussion
These findings add to the literature by indicating that ARFID patients are commonly male or have diverse gender identities, and have high rates of neurodevelopmental, mood, anxiety, and gastrointestinal disorders. We also found high rates of PTSD. The findings show promise for treatment outcomes across the continuum of care. Next steps in ARFID treatment and research include incorporating ARFID-specific assessments into routine care, and ongoing research investigating the efficacy and effectiveness of treatments such as CBT-AR.
Progesterone receptor distribution in the human hypothalamus and its association with suicide
Authors: Zhang Lin , Verwer Ronald W.H. , van Heerikhuize Joop , Lucassen Paul J. , Nathanielsz Peter W. , Hol Elly M. , Aronica Eleonora , Dhillo Waljit S. , Meynen Gerben , Swaab Dick F. 
Published: January 2024

AbstractThe human hypothalamus modulates mental health by balancing interactions between hormonal fluctuations and stress responses. Stress-induced progesterone release activates progesterone receptors (PR) in the human brain and triggers alterations in neuropeptides/neurotransmitters. As recent epidemiological studies have associated peripheral progesterone levels with suicide risks in humans, we mapped PR distribution in the human hypothalamus in relation to age and sex and characterized its (co-) expression in specific cell types. The infundibular nucleus (INF) appeared to be the primary hypothalamic structure via which progesterone modulates stress-related neural circuitry. An elevation of the number of pro-opiomelanocortin+(POMC, an endogenous opioid precursor) neurons in the INF, which was due to a high proportion of POMC+neurons that co-expressed PR, was related to suicide in patients with mood disorders (MD). MD donors who died of legal euthanasia were for the first time enrolled in a postmortem study to investigate the molecular signatures related to fatal suicidal ideations. They had a higher proportion of PR co-expressing POMC+neurons than MD patients who died naturally. This indicates that the onset of endogenous opioid activation in MD with suicide tendency may be progesterone-associated. Our findings may have implications for users of progesterone-enriched contraceptives who also have MD and suicidal tendencies.
Adsorption performance of bentonite and clay for Zn(II) in landfill leachate
Authors: Sun Wen-Jing , Tang Qian-Tong , Lu Tian-Hao , Fan Ri-Dong , Sun Gao-Ge , Tan Yun-zhi 
Published: January 2024

Abstract
Background
The increasing prevalence of the Galvanized and dry battery industries has led to a rise in zinc proportions in landfills, posing environmental risks. This study explores the potential of bentonite, renowned for its metal adsorption capability, as a landfill barrier material.

Methods
Adsorption characteristics of Zn(II) in natural bentonite and Shanghai clay were investigated. Various factors affecting Zn(II) adsorption, including pH, Na ion strength, contact time, initial Zn(II) concentration, and adsorption temperature, were analyzed through batch-type adsorption tests.

Results
The change in pH and Na strength demonstrates no significant impact on the adsorption of Zn(II) onto bentonite, highlighting the strong selectivity of bentonite for Zn(II). Conversely, the equilibrium adsorption capacity of Zn(II) onto clay increases with rising pH or decreasing ion strength. The Zn(II) adsorption onto bentonite is well-described by the pseudo-second-order, intra-particle diffusion, and Elovih models, each achieving an R2 value exceeding 0.9. While both physical and chemical adsorption coexist in Zn(II) adsorption onto bentonite or clay, the primary determinant of the adsorption rate is chemical adsorption. The adsorption onto bentonite is spontaneous, whereas onto clay it is not. The mechanism involves van der Waals forces, ion exchange, and chemical actions such as inner-sphere complexation for Zn(II) adsorption onto both bentonite and clay.
Sacituzumab Govitecan in Combination With Pembrolizumab for Patients With Metastatic Urothelial Cancer That Progressed After Platinum-Based Chemotherapy: TROPHY-U-01 Cohort 3
Authors: Grivas Petros , Pouessel Damien , Park Chandler H. , Barthelemy Philippe , Bupathi Manojkumar , Petrylak Daniel P. , Agarwal Neeraj , Gupta Sumati , Fléchon Aude , Ramamurthy Chethan , Davis Nancy B. , Recio-Boiles Alejandro , Sternberg Cora N. , Bhatia Astha , Pichardo Cabilia , Sierecki Mitch , Tonelli Julia , Zhou Huafeng , Tagawa Scott T. , Loriot Yohann 
Published: January 2024

PURPOSE Pembrolizumab is standard therapy for patients with metastatic urothelial cancer (mUC) who progress after first-line platinum-based chemotherapy; however, only approximately 21% of patients respond. Sacituzumab govitecan (SG) is a trophoblast cell surface antigen-2–directed antibody-drug conjugate with US Food and Drug Administration–accelerated approval to treat patients with locally advanced or mUC who previously received platinum-based chemotherapy and a checkpoint inhibitor (CPI). Here, we report the primary analysis of TROPHY-U-01 cohort 3. METHODS TROPHY-U-01 (ClinicalTrials.gov identifier: NCT03547973 ) is a multicohort, open-label phase II study. Patients were CPI-naïve and had mUC progression after platinum-based chemotherapy in the metastatic setting or ≤12 months in the (neo)adjuvant setting. Patients received 10 mg/kg of SG once on days 1 and 8 and 200 mg of pembrolizumab once on day 1 of 21-day cycles. The primary end point was objective response rate (ORR) per central review. Secondary end points included clinical benefit rate (CBR), duration of response (DOR) and progression-free survival (PFS) per central review, and safety. RESULTS Cohort 3 included 41 patients (median age 67 years; 83% male; 78% visceral metastases [29% liver]). With a median follow-up of 14.8 months, the ORR was 41% (95% CI, 26.3 to 57.9; 20% complete response rate), CBR was 46% (95% CI, 30.7 to 62.6), median DOR was 11.1 months (95% CI, 4.8 to not estimable [NE]), and median PFS was 5.3 months (95% CI, 3.4 to 10.2). The median overall survival was 12.7 months (range, 10.7-NE). Grade ≥3 treatment-related adverse events occurred in 61% of patients; most common were neutropenia (37%), leukopenia (20%), and diarrhea (20%). CONCLUSION SG plus pembrolizumab demonstrated a high response rate with an overall manageable toxicity profile in patients with mUC who progressed after platinum-based chemotherapy. No new safety signals were detected. These data support further evaluation of SG plus CPI in mUC.
Plant Foods Intake and Risk of Premature Aging in Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort (SJLIFE)
Authors: Wang Mei , Lan Tuo , Williams AnnaLynn M. , Ehrhardt Matthew J. , Lanctot Jennifer Q. , Jiang Shu , Krull Kevin R. , Armstrong Gregory T. , Hudson Melissa M. , Colditz Graham A. , Robison Leslie L. , Ness Kirsten K. , Park Yikyung 
Published: January 2024

PURPOSE To identify dietary factors that are related to premature aging in adult survivors of childhood cancer, we examined the associations between plant food intakes and age-related deficit accumulation. METHODS A total of 3,322 childhood cancer survivors (age 18-65 years, mean = 31, standard deviation = 8.4) in the St Jude Lifetime Cohort had total fruit, total vegetables and subgroups, whole grains, refined grains, nuts/seeds, and nutrients intake assessed using a food frequency questionnaire. Premature aging at baseline was assessed by the deficit accumulation index (DAI) and categorized as low, medium, and high risk. Multinomial logistic regressions (reference: low risk) adjusting for confounders estimated odds ratios (ORs) and 95% CIs. Multivariable linear regression of a continuous intake against a continuous DAI was also performed. RESULTS Dark green vegetable (ORhigh v low = 0.47 [95% CI, 0.28 to 0.78] per 1/2 cup/1,000 kcal increment) and nuts/seeds intakes (ORhigh v low = 0.71 [95% CI, 0.47 to 1.08] per 1 oz/1,000 kcal increment; coefficientlinear = -0.0115, P = .02) were associated with a lower risk of premature aging. Conversely, refined grain intake was related to an increased risk of premature aging (ORhigh v low = 1.33 [95% CI, 0.99 to 1.78], per 1 oz/1,000 kcal increment; coefficientlinear = 0.0093, P = .005). Fruit and whole grain intakes were not associated with premature aging risk. Among nutrients abundant in plant foods, dietary folate intake was associated with a lower risk of premature aging (ORhigh v low = 0.89 [95% CI, 0.80 to 0.99] per 50 mcg/1,000 kcal increase). Beta-carotene, lutein/zeaxanthin, and vitamin E intakes from foods were also related to a modestly lower, but not statistically significant, risk of premature aging. CONCLUSION Specific plant foods are associated with lower risk of premature aging, providing targets for the interventions to promote healthy aging in childhood cancer survivors.
Multi-soliton solutions and soliton molecules of the (2+1)-dimensional Boiti-Leon-Manna-Pempinelli equation for the incompressible fluid
Authors: Wang Kang-Jia , Shi Feng 
Published: January 2024

Abstract
The (2+1)-dimensional Boiti-Leon-Manna-Pempinelli equation (BLMPE) is explored in this letter. The multi-soliton solutions (MSSs) are probed via the Hirota bilinear form which is extracted by taking advantage of the Cole-Hopf transform. The soliton molecules (SMs) on the different planes such as the (x,y)-, (x,t)- and (y,t)-planes are investigated via assigning the velocity resonance mechanisms. The dynamic characteristics of the results are unveiled graphically to show the corresponding physical behaviors.
Health Care Challenges in the Management of Primary Aldosteronism in Southeast Asia
Authors: Sukor Norlela , Sunthornyothin Sarat , Tran Thang V , Tarigan Tri Juli , Mercado-Asis Leilani B , Sum Satha , Aung Moe Wint , Yong Alice M L , Tedjo Tania , Villa Michael , Khaing Nang Ei Ei , Azizan Elena Aisha , Kang Waye Hann , Lim Vivien , Teo Ada E D , Zhang Meifen , Tran Hieu , Puar Troy H 
Published: January 2024

Abstract

Context
While guidelines have been formulated for the management of primary aldosteronism (PA), following these recommendations may be challenging in developing countries with limited health care access.

Objective
We aimed to assess the availability and affordability of health care resources for managing PA in the Association of Southeast Asian Nations (ASEAN) region, which includes low-middle-income countries.

Methods
We instituted a questionnaire-based survey to specialists managing PA, assessing the availability and affordability of investigations and treatment. Population and income status data were taken from the national census and registries.

Results
Nine ASEAN country members (48 respondents) participated. While screening with aldosterone-renin ratio is performed in all countries, confirmatory testing is routinely performed in only 6 countries due to lack of facilities and local assays, and cost constraint. Assays are locally available in only 4 countries, and some centers have a test turnaround time exceeding 3 weeks. In 7 countries (combined population of 442 million), adrenal vein sampling (AVS) is not routinely performed due to insufficient radiological facilities or trained personnel, and cost constraint. Most patients have access to adrenalectomy and medications. In 6 countries, the cost of AVS and adrenalectomy combined is more than 30% of its annual gross domestic product per capita. While most patients had access to spironolactone, it was not universally affordable.

Conclusion
Large populations currently do not have access to the health care resources required for the optimal management of PA. Greater efforts are required to improve health care access and affordability. Future guideline revisions for PA may need to consider these limitations.
RETURN TO SPORT FOLLOWING CLOSED ACHILLES TENDON RUPTURE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF ELIGIBLE STUDIES EVALUATING MANAGEMENT STRATEGIES, PATIENT FACTORS, AND LEVEL OF ATHLETIC ACTIVITY
Authors: Roberts R. H. R. , Glendenning A. C. , Davies-Jones G. R. 
Published: January 2024

IntroductionAchilles Tendon Rupture (ATR) is a prevalent injury in Western society. Much of the recent research has focused on measuring surgical methods and strength regained, rather than practical measures such as Return to Sport (RTS). A large systematic review was published in 2016 setting a benchmark RTS as 80%. The aim of this systematic review was to provide an up-to-date RTS following ATR.MethodsPubMed and SPORTdiscuss databases were used to search for eligible studies published since 2017 that focused on closed Achilles tendon ruptures with clear definitions of return to sport and a minimum length of follow-up. The Newcastle-Ottawa grading tool was used to assess risk of bias in all included studies.ResultsOf 15 articles identified, 9 were ‘good’ and 6 were ‘fair’ after bias assessment, with none excluded for being poor. Return-to-sport (RTS) rate following Achilles tendon rupture was 76.76% (95% CI 74.19, 79.34 P= <0.001). Non-professional athletes had a higher RTS rate (78.29%; 95% CI 74.89, 81.68 P= <0.001) than professional athletes (74.91%; 95% CI 70.98, 78.85 P= <0.001). Surgical intervention resulted in a lower RTS rate (74.17%; 95% CI 70.74, 77.60 P= <0.001) than conservative management (70.00%; 95% CI 60.48, 79.52 P= <0.001).ConclusionThese findings highlight the need to identify factors affecting RTS rates, including the type of management, level of sport, and patient-specific factors. Clinicians can use these findings to guide informed shared decision-making with patients regarding the long-term implications of ATR and to develop more targeted rehabilitation strategies for this injury.