bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-Reported Outcomes After Vestibular Implantation for Bilateral Vestibular Hypofunction
Authors: Ayiotis Andrianna I. , Schoo Desi P. , Fernandez Brillet Celia , Lane Kelly E. , Carey John P. , Della Santina Charles C. 
Published: February 2024

ImportanceStandard-of-care treatment proves inadequate for many patients with bilateral vestibular hypofunction (BVH). Vestibular implantation is an emerging alternative.ObjectiveTo examine patient-reported outcomes from prosthetic vestibular stimulation.Design, Setting, and ParticipantsThe Multichannel Vestibular Implant (MVI) Early Feasibility Study is an ongoing prospective, nonrandomized, single-group, single-center cohort study conducted at Johns Hopkins Hospital that has been active since 2016 in which participants serve as their own controls. The study includes adults with severe or profound adult-onset BVH for at least 1 year and inadequate compensation despite standard-of-care treatment. As of March 2023, 12 candidates completed the eligibility screening process.InterventionThe MVI system electrically stimulates semicircular canal branches of the vestibular nerve to convey head rotation.Main Outcomes and MeasuresPatient-reported outcome instruments assessing dizziness (Dizziness Handicap Inventory [DHI]) and vestibular-related disability (Vestibular Disorders–Activities of Daily Living [VADL]). Health-related quality of life (HRQOL) assessed using the Short Form-36 Utility (SF36U) and Health Utilities Index Mark 3 (HUI3), from which quality-adjusted life-years were computed.ResultsTen individuals (5 female [50%]; mean [SD] age, 58.5 [5.0] years; range, 51-66 years) underwent unilateral implantation. A control group of 10 trial applicants (5 female [50%]; mean [SD] age, 55.1 [8.5] years; range, 42-73 years) completed 6-month follow-up surveys after the initial application. After 0.5 years of continuous MVI use, a pooled mean (95% CI) of within-participant changes showed improvements in dizziness (DHI, −36; 95% CI, −55 to −18), vestibular disability (VADL, −1.7; 95% CI, −2.6 to −0.7), and HRQOL by SF36U (0.12; 95% CI, 0.07-0.17) but not HUI3 (0.02; 95% CI, −0.22 to 0.27). Improvements exceeded minimally important differences in the direction of benefit (exceeding 18, 0.65, and 0.03, respectively, for DHI, VADL, and SF36U). The control group reported no mean change in dizziness (DHI, −4; 95% CI, −10 to 2), vestibular disability (VADL, 0.1; 95% CI, −0.9 to 1.1) or HRQOL per SF36U (0; 95% CI, −0.06 to 0.05) but an increase in HRQOL per HUI3 (0.10; 95% CI, 0.04-0.16). Lifetime HRQOL gain for MVI users was estimated to be 1.7 quality-adjusted life-years (95% CI, 0.6-2.8) using SF36U and 1.4 (95% CI, −1.2 to 4.0) using HUI3.Conclusions and RelevanceThis cohort study found that vestibular implant recipients report vestibular symptom improvements not reported by a control group. These patient-reported benefits support the use of vestibular implantation as a treatment for bilateral vestibular hypofunction.
Hofmeister Effect‐Assisted Facile One‐Pot Fabrication of Double Network Organohydrogels with Exceptional Multi‐Functions
Authors: Yu Deshuai , Yi Jia , Zhu Shuihong , Tang Yonghua , Huang Yanyan , Lin Da , Lin Youhui 
Published: February 2024

AbstractMulti‐functional hydrogels have gained attention for their potential as smart materials in diverse applications. However, most established design principles and fabrication methods are considered as convoluted and ineffective. Here, by using a simple one‐pot and efficient method, a novel PAAm/Gelatin/Ammonium sulfate organohydrogel (PGAOH) with exceptional multifunctionality, including anti‐freezing properties, excellent conductivity, remarkable stability, free‐shapeable, sensitivity, elasticity, high transparency, and resistance to drying is developed. In this system, it is surprisingly discovered that in the presence of acrylamide molecules, gelatin can disperse well in high‐concentration salting‐out solutions, significantly shorten the preparation time for the gel, allows for precise control of gel volume. More importantly, acrylamide can form another polyacrylamide network, further enhancing the mechanical properties of the PGAOH. Additionally, the introduction of glycerol notably improved the environmental stability of the PGAOH and effectively enhanced its mechanical properties and transparency. These innovative combinations result in PGAOH possessing exceptional multifunctionality, demonstrated by its successful application in a wireless virtual reality (VR) gaming device.
Recent Development and Future Frontiers of Oxygen Reduction Reaction in Neutral Media and Seawater
Authors: Vo Truong‐Giang , Gao Jiajian , Liu Yan 
Published: February 2024

AbstractThe oxygen reduction reaction (ORR) in neutral media is of great importance due to its potential to optimize energy generation and storage application. With the increasing urgency for sustainable and efficient energy solutions, comprehensively understanding and enhancing ORR performance in such media have become crucial. This review aims to shed light on this critical yet challenging area. This review encapsulates the fundamental principle of ORR and the latest breakthrough in the field of electrocatalysts, with a distinct focus on innovative synthesis strategies for creating novel, efficient, and robust electrocatalysts. A succinct evaluation of the strengths, limitations, performance, and reaction mechanism is presented. The essential findings are analyzed and their implications for future research directions. Finally, an outlook on current advances, challenges, and future research recommendations is provided. This review serves as a stepping‐stone toward harnessing the underutilizing energy potential within the extensive aquatic environment.
Self‐Sterilizing Microneedle Sensing Patches for Machine Learning‐Enabled Wound pH Visual Monitoring
Authors: Xiao Jingyu , Zhou Zhongzeng , Zhong Geng , Xu Tailin , Zhang Xueji 
Published: February 2024

AbstractThe skin, as the body's largest organ, is closely linked to an individual's health. Delayed diagnosis and treatment of skin infections can lead to complications such as non‐healing wounds and sepsis. Despite significant, early identification of wound infections and timely treatment of non‐healing wounds remain a challenge that requires continuous management. This work presents a novel strategy that combines smart microneedle sensing to inhibit wound infection and track wound healing status. The microneedle tip based on metal‐organic frameworks (MOF) hydrogel allows rapid self‐sterilization and promotes wound healing. The substrate of the microneedle patch based on pH–sensitive fluorescent reagents, can integrate with a smartphone to visualize images. Furthermore, it can be further reliably evaluated wound pH by applying a machine‐learning algorithm. The multifunctional microneedle sensing patch establishes a strategy that combines therapy and sensing to address delayed wound management, promotes the design and optimization of MOF hydrogels, and contributes a facile way for disease diagnosis and personalized health management.
Memory‐Processing‐Display Integrated Hardware with All‐In‐One Structure for Intelligent Image Processing
Authors: Shan Liuting , Yu Rengjian , Chen Zhenjia , Zhang Xianghong , Gao Changsong , Lian Minrui , Hu Yuanyuan , Guo Tailiang , Chen Huipeng 
Published: February 2024

AbstractEmpowering displays with intelligent functions enables their application in intelligent image processing and intelligent interactive displays, which is the combination of future display and artificial intelligence technologies. However, existing display technologies face significant processing and transmission burdens due to their conventional hardware separation architecture, which separates memory from the processor and display module from the processing module. To address these challenges, a highly integrated memory‐ processing‐display intelligent light‐emitting hardware (MPDIH) capable of information generation, memory, processing, and visualization is proposed. The MPDIH, based on an organic light‐sensitive layer and activated by ultraviolet light irradiation, exhibits unique photoinhibition behavior attributed to the reverse light‐induced electric field formed by the directional arrangement of photo‐generated excitons. This behavior enables dynamic regulation and autonomous learning during the device training process. Leveraging this phenomenon, intelligent image processing is successfully demonstrated, achieving a significant contrast improvement with a maximum enhancement of 261% compared to unprocessed raw signals. Furthermore, the memory‐processing‐display intelligent image processing scheme enables fashion MNIST image recognition using an artificial neural network, and achieves noticeably higher recognition accuracy (>89%) compared to the original fuzzy images (<59%). Consequently, the proposed memory‐processing‐display intelligent light‐emitting hardware holds promise for future applications in integrated photonic systems and interactive artificial intelligence displays.
Mn Single‐Atom Nanozyme Functionalized 3D‐Printed Bioceramic Scaffolds for Enhanced Antibacterial Activity and Bone Regeneration
Authors: Gao Zongyan , Song Zhenyu , Guo Rong , Zhang Meng , Wu Jiamin , Pan Mingzhu , Du Qiuzheng , He Yaping , Wang Xuanzong , Gao Li , Jin Yi , Jing Ziwei , Zheng Jia 
Published: February 2024

AbstractInfective bone defect is increasingly threatening human health. How to achieve the optimal antibacterial activity and regenerative repair of infective bone defect simultaneously is a huge challenge in clinic. Herein, this work reports a rational integration of Mn single‐atom nanozyme into the 3D‐printed bioceramic scaffolds (Mn/HSAE@BCP scaffolds). The integrated Mn/HSAE@BCP scaffolds can catalyze the conversion of H2O2 to produce hydroxyl radical (•OH) and superoxide anion (O2•−) through cascade reaction. Besides, the prominent thermal conversion efficiency of Mn/HSAE@BCP scaffolds can be utilized for sonodynamic therapy (SDT). The synergetic strategy of chemodynamic therapy (CDT)/SDT enables the sufficient generation of reactive oxygen species (ROS) to kill Staphylococcus aureus (S. aureus) or Escherichia coli (E. coli). Furthermore, the enhanced antibacterial efficacy of Mn/HSAE@BCP scaffolds is beneficial to upregulate the expression of osteogenesis‐related markers (such as collagen 1(COL1), Runt‐related transcription factor 2 (Runx2), osteocalcin (OCN), and osteoprotegerin (OPG)) in vitro and further promote bone regeneration in vivo. The results demonstrate the good potential of Mn/HSAE@BCP scaffolds for the enhanced antibacterial activity and bone regeneration, which provide an effective method for the treatment of clinical infective bone defect.
Reversible Mechanical Contraception and Endometriosis Treatment Using Stimuli‐Responsive Hydrogels
Authors: Anthis Alexandre H.C. , Kilchenmann Samuel , Murdeu Manon , LeValley Paige J. , Wolf Morris , Meyer Charlotte , Cipolato Oscar , Tibbitt Mark W. , Rosendorf Jachym , Liska Vaclav , Rduch Thomas , Herrmann Inge K. 
Published: February 2024

AbstractFemale sterilization via fallopian tube ligation is a common procedure; However, after the operation, over 10% of women seek re‐fertilization, which is frequently unsuccessful. In addition, there is evidence that fallopian tubes contribute to the spread of endometriotic tissue as they serve as channels for proinflammatory media entering the abdominal cavity via retrograde menstruation. Here, stimuli‐degradable hydrogel implants are presented for the functional, biocompatible, and reversible occlusion of fallopian tubes. The hydrogel implants, designed with customized swelling properties, mechanically occlude fallopian tubes in a high‐performance manner with burst pressures reaching 255–558 mmHg, exceeding normal abdominal pressures (95 mmHg). Their damage‐free removal can be achieved within 30 min using near‐visible UV light or a glutathione solution, employing a method akin to standard fallopian tube perfusion diagnostics. Ultrasound‐guided implant placement is demonstrated using a clinical hysteroscope in a human‐scale uterus model and biocompatibility in a porcine in vivo model. Importantly, the prevention of live sperm as well as endometrial cell passage through blocked fallopian tubes is demonstrated. Overall, a multifunctional system is presented that constitutes a possible means of on‐demand, reversible contraception along with the first‐ever mechanical approach to abdominal endometriosis prevention and treatment.
Achieving Clearance of Drug‐Resistant Bacterial Infection and Rapid Cutaneous Wound Regeneration Using an ROS‐Balancing‐Engineered Heterojunction
Authors: Geng Chong , He Shuai , Yu Sheng , Johnson Hannah M. , Shi Hongxing , Chen Yanbai , Chan Yau Kei , He Wenxuan , Qin Miao , Li Xiao , Deng Yi 
Published: February 2024

AbstractIntractable infected microenvironments caused by drug‐resistant bacteria stalls the normal course of wound healing. Sono‐piezodynamic therapy (SPT) is harnessed to combat pathogenic bacteria, but the superabundant reactive oxygen species (ROS) generated during SPT inevitably provoke severe inflammatory response, hindering tissue regeneration. Consequently, an intelligent nanocatalytic membrane composed of poly(lactic‐co‐glycolic acid) (PLGA) and black phosphorus /V2C MXene bio‐heterojunctions (2D2‐bioHJs) is devised. Under ultrasonication, 2D2‐bioHJs effectively eliminate drug‐resistant bacteria by disrupting metabolism and electron transport chain (ETC). When ultrasonication ceases, they enable the elimination of SPT‐generated ROS. The 2D2‐bioHJs act as a “lever” that effectively achieves a balance between ROS generation and annihilation, delivering both antibacterial and anti‐inflammatory properties to the engineered membrane. More importantly, in vivo assays corroborate that the nanocatalytic membranes transform the stalled chronic wound environment into a regenerative one by eradicating the bacterial population, dampening the NF‐κB inflammatory pathway and promoting angiogenesis. As envisaged, this work demonstrates a novel tactic to arm membranes with programmed antibacterial and anti‐inflammatory effects to remedy refractory infected wounds from drug‐fast bacteria.
Growth Control of InP/ZnSe Heterostructured Nanocrystals
Authors: Shin Doyoon , Lee Hak June , Jung Dongju , Chae Jong Ah , Park Jeong Woo , Lim Jaemin , Im Seongbin , Min Sejong , Hwang Euyheon , Lee Doh C. , Park Young‐Shin , Chang Jun Hyuk , Park Kyoungwon , Kim Junki , Park Ji‐Sang , Bae Wan Ki 
Published: February 2024

AbstractThe morphology of heterostructured semiconductor nanocrystals (h‐NCs) dictates the spatial distribution of charge carriers and their recombination dynamics and/or transport, which are the main performance indicators of photonic applications utilizing h‐NCs. The inability to control the morphology of heterovalent III‐V/II‐VI h‐NCs composed of heavy‐metal‐free elements hinders their practical use. As a case study of III‐V/II‐VI h‐NCs, the growth control of ZnSe epilayers on InP NCs is demonstrated here. The anisotropic morphology in InP/ZnSe h‐NCs is attributed to the facet‐dependent energy costs for the growth of ZnSe epilayers on different facets of InP NCs, and effective chemical means for controlling the growth rates of ZnSe on different surface planes are demonstrated. Ultimately, this article capitalizes on the controlled morphology of InP/ZnSe h‐NCs to expand their photophysical characteristics from stable and pure emission to environment‐sensitive one, which will facilitate their use in a variety of photonic applications.
Catalytic Nanodots‐Driven Pyroptosis Suppression in Nucleus Pulposus for Antioxidant Intervention of Intervertebral Disc Degeneration
Authors: Sun Kaiqiang , Yan Chen , Dai Xinyue , Shi Yangyang , Li Fudong , Chen Liang , Sun Jingchuan , Chen Yu , Shi Jiangang 
Published: February 2024

AbstractLow back pain resulting from intervertebral disc degeneration (IVDD) is a prevalent global concern; however, its underlying mechanism remains elusive. Single‐cell sequencing analyses revealed the critical involvement of pyroptosis in IVDD. Considering the involvement of reactive oxygen species (ROS) as the primary instigator of pyroptosis and the lack of an efficient intervention approach, this study developed carbonized Mn‐containing nanodots (MCDs) as ROS‐scavenging catalytic biomaterials to suppress pyroptosis of nucleus pulposus (NP) cells to efficiently alleviate IVDD. Catalytic MCDs have superior efficacy in scavenging intracellular ROS and rescuing homeostasis in the NP microenvironment compared with N‐acetylcysteine, a classical antioxidant. The data validates that pyroptosis plays a vital role in mediating the protective effects of catalytic MCDs against oxidative stress. Systematic in vivo assessments substantiate the effectiveness of MCDs in rescuing a puncture‐induced IVDD rat model, further demonstrating their ability to suppress pyroptosis. This study highlights the potential of antioxidant catalytic nanomedicine as a pyroptosis inhibitor and mechanistically unveils an efficient strategy for the treatment of IVDD.
Synthesis of Vinyl and 1,3‐Dienyl Sulfones Enabled by Photochemical Excitation of Halogen‐Bonding Complexes
Authors: Piedra Helena F. , Valdés Carlos , Plaza Manuel 
Published: February 2024

AbstractThe photochemical catalyst‐free radical‐based synthesis of vinyl and 1,3‐dienyl sulfones is disclosed. Mechanistic investigations support that the transformations rely on a visible‐light‐promoted activation of a halogen‐bonding complex, which is formed between an alkenyl (or 1,3‐dienyl) bromide and a sodium sulfinate salt. The reactions exhibit a wide functional group tolerance (compatible with heteroatoms, electron‐withdrawing and electron‐donating groups), finding application in the structural modification of biologically relevant molecules. Eventually, a continuous flow protocol was developed to upscale these transformations.
Efficacy and safety of daratumumab with ixazomib and dexamethasone in lenalidomide‐exposed patients after one prior line of therapy: Final results of the phase 2 study DARIA
Authors: Terpos Evangelos , Ntanasis‐Stathopoulos Ioannis , Gavriatopoulou Maria , Katodritou Eirini , Hatjiharissi Evdoxia , Malandrakis Panagiotis , Verrou Evgenia , Golfinopoulos Stavros , Migkou Magdalini , Manousou Kyriaki , Delimpasi Sosana , Symeonidis Argiris , Kastritis Efstathios , Dimopoulos Meletios A. 
Published: February 2024

AbstractThe use of lenalidomide in frontline therapy for patients with newly diagnosed multiple myeloma (MM) has increased the number of those who become refractory to lenalidomide at second line. In this context, we assessed the efficacy of daratumumab in combination with ixazomib and dexamethasone (Dara‐Ixa‐dex) in the prospective phase 2 study DARIA. Eligible patients had relapsed/refractory MM (RRMM) after one prior line with a lenalidomide‐based regimen. The primary endpoint was overall response rate (ORR). Secondary endpoints included survival outcomes, safety and changes in biomarkers of bone metabolism. Overall, 50 patients were enrolled (median age 69 years, 56% males). 32 (64%) patients were refractory to lenalidomide, and 17 (34%) had undergone autologous transplant. The ORR was 64% (n = 32); whereas 17 (34%) had a very good partial response or better. The median time to first response was 1.0 month. After a median follow‐up of 23.4 months, the median PFS and OS were 8.1 and 39.2 months, respectively. Furthermore, significant changes in markers of bone metabolism became evident as early as at 6 months on treatment. Regarding safety, 21 (42%) patients had ≥1 grade 3/4 adverse event (AE); the most common was thrombocytopenia (n = 9, 18%). 14 (28%) patients had ≥1 serious AE (SAE), the most common being acute kidney injury and pneumonia (n = 2, each). Four patients died due to infections. In conclusion, second‐line treatment with Dara‐Ixa‐dex in patients with RRMM pre‐treated with a lenalidomide‐based regimen resulted in rapid responses along with a favorable effect on bone metabolism.
PUF60 loss‐of‐function with normal cognition should be considered in the differential diagnosis of Klippel–Feil syndrome
Authors: Bach Michal Yacobi , Miron Sivan Reytan , Kurolap Alina , Feldman Hagit Baris 
Published: February 2024

AbstractKlippel–Feil syndrome (KFS) has a genetically heterogeneous phenotype with six known genes, exhibiting both autosomal dominant and autosomal recessive inheritance patterns. PUF60 is a nucleic acid‐binding protein, which is involved in a number of nuclear processes, including pre‐mRNA splicing, apoptosis, and transcription regulation. Pathogenic variants in this gene have been described in Verheij syndrome due to either 8q24.3 microdeletion or PUF60 single‐nucleotide variants. PUF60‐associated conditions usually include intellectual disability, among other findings, some overlapping KFS; however, PUF60 is not classically referred to as a KFS gene. Here, we describe a 6‐year‐old female patient with clinically diagnosed KFS and normal cognition, who harbors a heterozygous de novo variant in the PUF60 gene (c.1179del, p.Ile394Serfs*7). This is a novel frameshift variant, which is predicted to result in a premature stop codon. Clinically, our patient demonstrates a pattern of malformations that matches reported cases of PUF60 variants; however, unlike most others, she has no clear learning difficulties. In light of these findings, we propose that PUF60 should be considered in the differential diagnosis of KFS and that normal cognition should not exclude its testing.
Pd(II)‐Catalyzed [3+2] Annulation of N‐Aryl‐2‐aminopyridines and Alkynes toward N‐(2‐Pyridyl)indoles
Authors: Guo Wenting , Hu Weiming , Zhang Xinyu , Huang Jiali , Wang Huiyan , Xia Ming , Tao Li 
Published: February 2024

AbstractA Pd‐catalyzed formal [3+2] oxidative annulation of N‐aryl‐2‐aminopyridines and alkynes through pyridyl group directed C−H activation has been developed. This methodology provides a mild and atom‐economic approach for the efficient synthesis of highly substituted indoles in moderate to good yields, which features with mild reaction conditions, good functional group compatibility, operational simplicity and easy scale‐up.
Vacancies‐regulated Prussian Blue Analogues through Precipitation Conversion for Cathodes in Sodium‐ion Batteries with Energy Densities over 500 Wh/kg
Authors: Liu Jiahe , Wang Yichao , Jiang Ning , Wen Bo , Yang Cheng , Liu Yu 
Published: February 2024

AbstractPrussian blue analogues (PBAs) have been widely applied in many fields, especially as cathode materials of sodium‐ion batteries on account of their low cost and open framework for fast ions transport. However, the capacity of reported PBAs has a great distance from its theoretical value. Herein, we proposed that [Fe(CN)6] vacancies are crucial point for the high specific capacity for the first time. The [Fe(CN)6] vacancies may create net electrons and reduce obstacles to ionic transport, which is conducive to rate performance of PBAs by increasing electronic and ionic conductivity to some extent. As a proof of concept, a series of PBAs have been prepared by co‐precipitation method. And then, a novel precipitation conversion method has been designed, by which unique PBAs with a specific quantity of [Fe(CN)6] vacancies was successfully synthesized. Remarkably, the as‐prepared PBAs possessing hierarchical hollow morphology have reached a unprecedent level of high capacity (168 mAh g−1 at 25 mA g−1, close to PBAs’ theoretical capacity 170 mAh g−1), high rate performance (90 mAh g−1 at 5 A g−1), and high energy density (over 500 Wh kg−1).