bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Temperatur Dan Waktu Proses Anodisasi Puley Aluminium Dalam Larutan H2so4 Encer Dan Campuran Larutan (H2so4+H2c2o4) Encer
Authors: Budimulyani Estuti 
Published: October 2023

Aluminum anodizing is an electrochemical process on aluminum metal with the aim of obtaining a thin layer of aluminum oxide that are better than aluminum metal itself, known as alumina. This study focuses on the process of anodizing aluminum in a solution of H2SO4 and in mixtures with H2C2O4 watery, and the influence of the length of processing time and temperature on the characteristics of the coating solution is formed. In this research, test equipment SEM, EDX and micro hardness testing was instrumental in producing accurate data. Expected type layer is a layer which has a hardness value higher than the base metal and has shaped the structure of a barrier layer and a porous layer. The results achieved in this anodizing process shows the growth of a thin layer of “a porous layer” at a temperature of 16oC with alumina film growth rate 0.7133 μm per minute and a decrease in hardness HV 1.3 / μm per minute in a solution of H2SO4 200 g / l, being in the mix solution of H2SO4 200 g / l and mixed with oxalic acid at 10 to 40 g / l occurred a layer growth speed 0.073 μm to 0.173 μm per minute and 0.513 decrease in hardness HV / μm to 6.2 HV / μm.
Key words: anodizing Aluminium, hardness, temperature, time, solution of sulfuric acid and oxalic acid.

Abstrak
Anodisasi Aluminium merupakan suatu proses elektrokimia pada logam Aluminium dengan tujuan memperoleh lapisan tipis Aluminium Oksida yang sifatnya lebih baik dari pada logam Aluminium itu sendiri yang dikenal dengan alumina. Penelitian ini menitikberatkan pada proses anodisasi Aluminium dalam larutan H2SO4 dan dalam campurannya dengan H2C2O4 encer,serta pengaruh lamanya waktu proses dan suhu larutan terhadap karakteristik lapisan yang terbentuk. Pada penelitian ini,peralatan test SEM,EDX dan uji kekerasan mikro sangat berperan dalam menghasilkan data yang akurat. Jenis lapisan yang diharapkan adalah lapisan yang memiliki nilai kekerasan lebih tinggi dari logam dasarnya dan memiliki struktur berbentuk barrier layer maupun porous layer. Hasil yang dicapai pada proses anodisasi ini menunjukkan pertumbuhan lapisan tipis “porous layer” pada suhu 16oC dengan kecepatan pertumbuhan lapisan alumina 0,7133 μm per menit dan penurunan kekerasan 1,3 HV/μm permenit dalam larutan H2SO4 200 g/l,sedang dalam campuran larutan H2SO4 200 g/l dan campurannya dengan asam oksalat sebesar 10 sampai 40 g/l terjadi kecepatan pertumbuhan lapisan 0,073 μm sampai 0,173 μm per menit dan penurunan kekerasan 0,513 HV/μm sampai 6,2 HV/μm.
Kata kunci : Anodisasi Aluminiu , kekerasan , suhu, waktu, larutan asam sulfat dan asam oksala
A case report : 34 y.o male with incidental histopathological findings of Kaposi sarcoma without clinical history of human immunodeficiency virus (HIV)
Authors: Saputra Herman , Sriwidyani Ni Putu , Paskarani Putu Erika , Ndori Elisabeth E. 
Published: October 2023

Introduction: Kaposi sarcoma is a rare and challenging case especially in immunosuppressed patients that frequently doesn’t have specific manifestation. It usually caused by human herpes virus 8 virus infection and male patient with multiple lesion has high mortality rates. The aim of this study is to report 34 y.o Male with incidental histopathological findings of kaposi sarcoma without clinical history of Human Immunodeficiency Virus (HIV). Methodology: Descriptive study of the case report type, whose data were obtained from the patient's medical record. Result: This paper will report 34-year-old young adult male with clinically diagnosed with poroma and differential diagnosis of squamous cell carcinoma and pyogenic granuloma. The clinical sign was multiple skin lesion appear on his right nose and thumb in the last 6 months. The nodules are solitary with oval shape, erythema, firm borders and the nodule surface covered with brownish-yellow squama. In addition, imaging examination suspicious for soft tissue mass. The biopsy was performed, and histopathological finding exhibit a tumor mass consists of Kaposi sarcoma. Discussion: Furthermore, after pathological report revealed the diagnosis of Kaposi sarcoma then a provider-initiated HIV testing and counseling (PITC) examination is carried out and the test result showed reactive for HIV infection. So that, patient concluded to have predisposition of HIV infection with Kaposi sarcoma and treated for antiretrovirals (ARV), chemotherapy and routine clinical follow up. Conclusion : Kaposi sarcoma is a rare cancer caused by infection with the human herpesvirus 8 (HHV8). These lesions are often found in immunosuppressed patients such as HIV sufferers characterized by vascular proliferation. Through the incidental findings of Kaposi's sarcoma in patients who are not clinically suspected of having HIV, clinicopathological correlation is highly recommended. Therefore, the purpose of this writing can be a strong reference so that clinicians are more thorough in reviewing clinical patients and more detailed physical examinations.
Corte epidemiológico de hospitalizações e óbitos envolvendo acidentes de motocicletas no Estado do Pará entre 2010 e 2020
Authors: Silva Vilmar Carneiro da , Frazão Gustavo Pantoja , Pereira Wellington Gabriel Santa Rosa , Pojo Rayssa Renata Correa , Guimaraes Vinicius Antonio Pimentel , Bastos Jamilly Monteiro , Lopes Thalisson Pinheiro , Tramontin Daniela Ferreira , Vallinoto Mariana Cayres , Rodrigues Neto Jorge Lopes 
Published: October 2023

Introdução: O aumento da popularidade das motos como meio de transporte tem sido acompanhado por um preocupante aumento no número de acidentes e mortes no trânsito. Objetivo: Este estudo teve como objetivo avaliar o perfil epidemiológico dos condutores de moto vítimas de acidentes de trânsito, atendidos no Estado do Pará, durante o período de 2010 a 2020. Método: Este estudo utilizou um desenho epidemiológico ecológico descritivo e quantitativo para avaliar a morbidade hospitalar no Estado do Pará, durante o período de 2010 a 2020. Foram obtidas informações sobre a morbidade hospitalar através do DATASUS, utilizando o TABNET, e dados populacionais do IBGE. Resultado: Foram contabilizadas mais de 100 mil internações hospitalares no Estado do Pará, a grande maioria na Região metropolitana I, onde se encontra o Município de Ananindeua que, além de liderar em número de hospitalizações também lidera o ranking de municípios com maior número de óbitos. A prevalência do gênero masculino, pardos e com idades entre 20-24 anos. A taxa de mortalidade é maior no município de Belém com média de permanência de 11,3 dias. Conclusão: Os Municípios de Ananindeua e Belém emergem como epicentros desse cenário e, por isso, apresentam a necessidade de ações preventivas e políticas voltadas para a segurança no trânsito nessas duas localidades.
Fapemig e as ICT&Is de Minas Gerais: Qual projeto de desenvolvimento?
Authors: Ferreira Aurélio Alves , Rocha Célia Aparecida , Imori Denise , Castro José Flávio Morais , Faria Filho Luciano Mendes de 
Published: October 2023

Este artigo tem o objetivo de apresentar o sentido de desenvolvimento adotado pelas Instituições de Ciência, Tecnologia e Inovação (ICT&I), do Estado de Minas Gerais desde o início do século XX. Para atender a perspectiva requerida, utilizamos a metodologia qualitativa, quantitativa, de cunho descritivo, o que foi realizado a partir de um estudo e análise do financiamento do quantitativo de projetos de pesquisa aprovados pela Fundação de Amparo à Pesquisa do Estado de Minas Gerais (Fapemig), no periodo de 2008 a 2021. Para atender a esse fim, nossa investigação se concentrou na busca de dados sobre o perfil científico, tecnológico e inovativo de um total de 24 ICT&Is de Minas Gerais: 11 universidades federais do Estado, 5 institutos federais, Cefet-MG, 2 universidades estaduais, a PUC-Minas, Instituto Oswaldo Cruz, Unidade Instituto René Rachou (Fiocruz Minas), Empresa Brasileira de Pesquisa Agropecuária, Unidade Gado de Leite (Embrapa), Fundação Ezequiel Dias (Funed) e Empresa de Pesquisa Agropecuária de Minas Gerais (Epamig). Instituições marcadamente orientadas para atender à promoção do conhecimento e diretamente conectadas com os processos cognitivos que historicamente ocupam-se com as ciências básicas e aplicadas, tendo em vista o aprofundamento e ampliação do conhecimento sobre os seres humanos, as sociedades, a natureza e as culturas, o que exige contínuo investimento financeiro do Estado e dedicação da comunidade de pesquisa, na busca incessante por novas aprendizagens e novas descobertas.
Epidemiological study of pediatric patients with signs and symptoms of intracranial hypertension with non-invasive cerebral compliance
Authors: Say Luana , Correia Miqueias Moreira , Folchini Caroline Mensor , Manços Guilherme de Rosso , Ricieri Marinei Campos , Motta Fábio de Araújo , Maeda Adriano Keijiro , Karuta Simone Carreiro Vieira 
Published: October 2023

Introduction: Intracranial hypertension (IH) is a clinical condition secondary to the loss of cerebral compensatory mechanisms. There are distinct methodologies used to diagnose IH and among them is the brain4care (b4c) sensor, which allows non-invasive monitoring of intracranial volume and pressure variations, intracranial compliance. Objective: To characterize the epidemiological profile of patients with suspected IH in the pediatric age range. Method: A cross-sectional study was carried out in a reference pediatric hospital in Brazil, with patients with signs and symptoms of IH monitored with the non-invasive B4C sensor. The patients underwent neurological evaluation and were submitted to exams - ophthalmological evaluation, lumbar puncture, magnetic resonance imaging (MRI) and computed tomography (CT). Result: 58 patients were evaluated, of whom 32 are female (55.2%) and 26 are male (44.8%); most patients presented symptoms such as drowsiness (81%), nausea (77.6%), headache (74.1%), vomiting (63.8%). The ophthalmoscopic examination 77.6% (n=58) of the patients did not show signs of papilledema. On CT and MRI, no changes were found in 84.5% (n=58) and 69.2% (n=26), respectively. Lumbar puncture showed changes in 57.1% (n=21). Considering the interpretation that would be made in adult patients, the b4c sensor monitoring (n=58) showed probable changes in the lying and sitting positions, respectively, in 46.3% and 38.9%. Conclusion: It was found that the b4c device can provide a possible complement of clinical information in the process of monitoring cerebral compliance.
GcForest-based compound-protein interaction prediction model and its application in discovering small-molecule drugs targeting CD47
Authors: Shan Wenying , Chen Lvqi , Xu Hao , Zhong Qinghao , Xu Yinqiu , Yao Hequan , Lin Kejiang , Li Xuanyi 
Published: October 2023

Identifying compound–protein interaction plays a vital role in drug discovery. Artificial intelligence (AI), especially machine learning (ML) and deep learning (DL) algorithms, are playing increasingly important roles in compound-protein interaction (CPI) prediction. However, ML relies on learning from large sample data. And the CPI for specific target often has a small amount of data available. To overcome the dilemma, we propose a virtual screening model, in which word2vec is used as an embedding tool to generate low-dimensional vectors of SMILES of compounds and amino acid sequences of proteins, and the modified multi-grained cascade forest based gcForest is used as the classifier. This proposed method is capable of constructing a model from raw data, adjusting model complexity according to the scale of datasets, especially for small scale datasets, and is robust with few hyper-parameters and without over-fitting. We found that the proposed model is superior to other CPI prediction models and performs well on the constructed challenging dataset. We finally predicted 2 new inhibitors for clusters of differentiation 47(CD47) which has few known inhibitors. The IC50s of enzyme activities of these 2 new small molecular inhibitors targeting CD47-SIRPα interaction are 3.57 and 4.79 μM respectively. These results fully demonstrate the competence of this concise but efficient tool for CPI prediction.
Unsupervised cluster analysis of clinical and metabolite characteristics in patients with chronic complications of T2DM: an observational study of real data
Authors: Wang Cuicui , Li Yan , Wang Jun , Dong Kunjie , Li Chenxiang , Wang Guiyan , Lin Xiaohui , Zhao Hui 
Published: October 2023

IntroductionThe aim of this study was to cluster patients with chronic complications of type 2 diabetes mellitus (T2DM) by cluster analysis in Dalian, China, and examine the variance in risk of different chronic complications and metabolic levels among the various subclusters.Methods2267 hospitalized patients were included in the K-means cluster analysis based on 11 variables [Body Mass Index (BMI), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Glucose, Triglycerides (TG), Total Cholesterol (TC), Uric Acid (UA), microalbuminuria (mAlb), Insulin, Insulin Sensitivity Index (ISI) and Homa Insulin-Resistance (Homa-IR)]. The risk of various chronic complications of T2DM in different subclusters was analyzed by multivariate logistic regression, and the Kruskal-Wallis H test and the Nemenyi test examined the differences in metabolites among different subclusters.ResultsFour subclusters were identified by clustering analysis, and each subcluster had significant features and was labeled with a different level of risk. Cluster 1 contained 1112 inpatients (49.05%), labeled as “Low-Risk”; cluster 2 included 859 (37.89%) inpatients, the label characteristics as “Medium-Low-Risk”; cluster 3 included 134 (5.91%) inpatients, labeled “Medium-Risk”; cluster 4 included 162 (7.15%) inpatients, and the label feature was “High-Risk”. Additionally, in different subclusters, the proportion of patients with multiple chronic complications was different, and the risk of the same chronic complication also had significant differences. Compared to the “Low-Risk” cluster, the other three clusters exhibit a higher risk of microangiopathy. After additional adjustment for 20 covariates, the odds ratios (ORs) and 95% confidence intervals (95%CI) of the “Medium-Low-Risk” cluster, the “Medium-Risk” cluster, and the”High-Risk” cluster are 1.369 (1.042, 1.799), 2.188 (1.496, 3.201), and 9.644 (5.851, 15.896) (all p&lt;0.05). Representatively, the “High-Risk” cluster had the highest risk of DN [OR (95%CI): 11.510(7.139,18.557), (p&lt;0.05)] and DR [OR (95%CI): 3.917(2.526,6.075), (p&lt;0.05)] after 20 variables adjusted. Four metabolites with statistically significant distribution differences when compared with other subclusters [Threonine (Thr), Tyrosine (Tyr), Glutaryl carnitine (C5DC), and Butyryl carnitine (C4)].ConclusionPatients with chronic complications of T2DM had significant clustering characteristics, and the risk of target organ damage in different subclusters was significantly different, as were the levels of metabolites. Which may become a new idea for the prevention and treatment of chronic complications of T2DM.
Prevalence and influencing factors of abnormal carotid artery intima-media thickness in Henan Province in China
Authors: Yang Tingting , Wang Yating , Zhang Xiaoke , Xiang Siyun , Wen Jing , Wang Wen , Guan Ke , Wang Weixiang , Yang Yang , Hao Liuwei , Chen Yongchun 
Published: October 2023

BackgroundCarotid intima-media thickness (CIMT) has been shown to be a valuable predictor of cardiovascular diseases (CVDs). The aim of this study was to investigate the influencing factors of CIMT among adults in Central China.MethodsA total of 2,578 participants who underwent physical examination in Henan Provincial People’s Hospital between January 2018 and July 2018 were enrolled. The respondents were divided into two subgroups according to their CIMT value (CIMT ≥1.0 mm group and CIMT &lt;1.0 mm group). Variables considered were age, gender, total cholesterol, triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) triglycerides, fasting blood glucose, and uric acid levels, as well as hypertension, diabetes, body mass index (BMI), waist-to-hip ratio, body fat percentage, and visceral fat area (VFA). Logistic regression analysis was performed to explore the potential factors influencing CIMT.ResultsThe proportion of CIMT ≥1.0 mm among the physical examination population was 27.42% (707/2 578). The analysis of the two groups revealed significant differences in age, sex, hypertension, diabetes, total cholesterol, and HDL cholesterol. In the logistic regression analysis, age (OR=1.071, 95%CI=1.062–1.080), male sex (OR=2.012, 95%CI=1.251–2.238), hypertension (OR=1.337, 95%CI=1.031–1.735), diabetes (OR=1.535, 95%CI=1.045–2.255), HDL cholesterol (OR=0.540, 95%CI=0.366–0.796), and LDL cholesterol (OR=1.336, 95%CI=1.154–1.544) were significantly associated with abnormal CIMT.ConclusionEarly screening should be carried out among men, the older adults, and those with hypertension, diabetes, and dyslipidemia.
Connectivity, land use, and fish presence influence smooth newt (Lissotriton vulgaris) occurrence and abundance in an urban landscape
Authors: Vehkaoja Mia , Thompson Stella M. A. , Niemi Milla , Väänänen Veli-Matti 
Published: October 2023

IntroductionUrban areas are challenging environments for wetland species with complex habitat requirements and life cycles. However, even semiaquatic species, representing such complex wetland groups, can be provided with adequate conditions through thorough understanding of their habitat requirements coupled with comprehensive wetland management.MethodsWe studied the occurrence and abundance of the smooth newt (Lissotriton vulgaris), a widely distributed amphibian, in an urban landscape in metropolitan Helsinki, Finland. We classified 50 randomly selected urban wetlands based on their connectivity by applying isolation scores counted using principal component analysis (PCA) and measured the occurrence and abundance of smooth newts in these locations.ResultsOur analyses showed well-connected wetland sites to differ significantly in smooth newt occurrence from both isolated and partially connected sites. Additionally, smooth newt abundance in well-connected wetlands differed from isolated sites. A PCA model with residential buildings (negative effect) and aquatic vegetation (positive effect) best explained smooth newt occurrence and total and male abundance, and female newt occurrence was best explained by a model also incorporating forest and natural open areas. Predation pressure by fish negatively influenced both smooth newt occurrence and abundance.DiscussionTighter networks of constructed wetlands and stricter management guidelines for urban wetland planning and fish community management could increase the suitable habitat for smooth newts in urban landscapes. Managing such areas for the common smooth newt offers potential broad benefits to the conservation of other semiaquatic amphibians and reptiles in urban wetlands and to urban wetland biodiversity in general. Our results show that smooth newt presence may indicate sustained wetland connectivity in an urban landscape and could even be used to signal successful urban planning.
Preclinical study of CD19 detection methods post tafasitamab treatment
Authors: Ilieva Kristina , Eberl Markus , Jaehrling Jan , Blair Derek , Patra-Kneuer Maria , Boxhammer Rainer , Alvarez Arias Diana , Heitmüller Christina 
Published: October 2023

IntroductionSeveral CD19 targeted antibody-based therapeutics are currently available for patients with diffuse large B-cell lymphoma (DLBCL), including the Fc-modified antibody immunotherapy tafasitamab. This therapeutic landscape warrants the evaluation of potential sequencing approaches. Prior to a subsequent CD19-targeted therapy, CD19 expression on tafasitamab-treated patient biopsy samples may be assessed. However, no standardized methods for its detection are currently available. In this context, selecting a tafasitamab-competing CD19 detection antibody for immunohistochemistry (IHC) or flow cytometry (FC) may lead to misinterpreting epitope masking by tafasitamab as antigen loss or downregulation.MethodsWe analyzed a comprehensive panel of commercially available CD19 detection antibody clones for IHC and FC using competition assays on tafasitamab pre-treated cell lines. To remove bound tafasitamab from the cell surface, an acidic dissociation protocol was used. Antibody affinities for CD19 were measured using Surface Plasmon Resonance (SPR) or Bio-Layer Interferometry (BLI).ResultsWhile CD19 was successfully detected on tafasitamab pre-treated samples using all 7 tested IHC antibody clones, all 8 tested FC antibody clones were confirmed to compete with tafasitamab. An acidic dissociation was demonstrated essential to circumvent CD19 masking by tafasitamab and avoid false negative FC results.DiscussionThe current study highlights the importance of selecting appropriate CD19 detection tools and techniques for correct interpretation of CD19 expression. The findings presented herein can serve as a guideline to investigators and may help navigate treatment strategies in the clinical setting.
Potential of medicinal plants as antimalarial agents: a review of work done at Kenya Medical Research Institute
Authors: Irungu Beatrice , Okari Erick , Nyangi Mary , Njeru Sospeter , Koech Lilian 
Published: October 2023

Background: Medicinal plants have traditionally been used as remedies against malaria. The present review attempted to compile data on scientific research evidence on antimalarial medicinal plants screened at Kenya Medical Research Institute (KEMRI), Center for Traditional Medicine and Drug (CTMDR) Research from January 2003 to December 2021.Methods: A systematic review was conducted using a predefined protocol based on PRISMA. Search was performed in Google Scholar and PubMed. One hundred and eight journal articles were identified 37 of which published on antimalarial/antiplasmodial work. Thirty journal articles with at least one author from KEMRI-CTMDR and accessible in full were selected for analysis. Relevant data was captured in MS Excel format and descriptive statistics, percentages and tables used to summarize the findings.Results: Assessment of individual plant species was considered as an independent study resulting in 1170 antiplasmodial/antimalarial tests done from 197 plant species. One hundred and fifty plant species were screened in vitro, one in vivo and 46 were both in vivo and in vitro. Three hundred and forty-four of tests reported good activity (IC50 &lt; 10 μg/mL or parasite suppression rate of ≥50%), 414 moderate activity (IC50 values of 10–49 μg/mL or parasite suppression rate of 30%–49%) and 412 were reports of inactivity (IC50 ˃ 50 μg/mL or parasite suppression rate of &lt;30%). Fuerstia africana and Ludwigia erecta were reported to have the highest activities, with IC50 &lt; 1 μg/mL against Plasmodium falciparum D6 strain and chemosuppression in mice at an oral dose of 100 mg/kg, was reported as 61.9% and 65.3% respectively. Fifty five antimalarial/antiplasmodial active compounds isolated from eight plant species were reported with resinone (39) having the best activity (IC50 &lt; 1 μg/mL).Conclusion: Though 344 of tests reported promising antimalarial activity, it was noted that there was limited evaluation of these plants in animal models, with only 9.0% (105/1170) studies and no clinical trials. This highlights an important research gap emphasizing the need for drug development studies that aim to progress study findings from preclinical to clinical studies. There is still need for extensive research on promising plant species aimed at developing new plant based antimalarial drugs.