bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Photoactivated Curcumin on Proliferation of Experimentally Induced Periodontitis and Diabetic Gingival Fibroblast Cell Line
Authors: Sharma Ananya , Bains Vivek Kumar , Chandra Chetan , Srivastava Ruchi , Soi Sunakshi , Singh Utkarsh , Pant Aditya Bhushan 
Published: January 2025

ABSTRACT

Objective:
To evaluate the impact of photoactivated curcumin on proliferation of experimentally induced periodontitis and diabetic gingival fibroblast in laboratory settings.

Materials and Methods:
Gingival fibroblast (GF) cells were divided into healthy GF (HGF), diabetic GF (DGF), and periodontitis-associated diabetic GF (P-DGF) cells that were treated with a solution of curcumin that was prepared and diluted in autoclave distilled water to obtain a concentration used (1 mg/ml). Gingival fibroblasts with curcumin and without curcumin were seeded in a 96-well plate that was treated with a light-emitting diode curing light with a wavelength of 445 nm using a transparent diffuser tip. All healthy (HGF) as well as diseased (DGF and P-DGF) gingival fibroblasts were thus treated with curcumin (c-only), photoactivation (p-only), and both photoactivated curcumin (pc-both) and were then histologically analyzed for evaluation of cell proliferation and viability of fibroblasts. The number of proliferated cells/proliferative values were calculated by relative fluorescence values displayed by a fluorimeter. The number of viable cells (%viability) correlates with the magnitude of dye reduction and expressed as percentage of Alamar-Blue reduction.

Results:
HGF group treated with p-alone, c-alone, and pc-both showed a significant increase in the fluorescence value and proliferation in the cells at 24 to 48 and 48 to 72 h, whereas for the DGF group, there was a statistically significant increase in the fluorescence value and proliferation when treated with p-alone from 24 to 72 h, with a significant decrease in the proliferation of the cells when treated with c-alone and pc-both at 24 to 48 h and 48 to 72 h. For the P-DGF group, a significant decrease in the fluorescence value and proliferation was observed when the cells were treated with p-alone and c-alone at 24 to 72 h.

Conclusion:
Photoactivation (p-alone) was the most efficient in depicting a highly significant increase in the percentage viability for the group P-DGF and DGF at 24 h, whereas a significant increase in the fluorescence value and proliferation was observed for the group P-DGF when treated with photoactivated curcumin (pc-both) from 24 to 72 h.
Evaluation of the Effect of Reverse Curve of Spee in Nickel Titanium (NiTi) Wire with and Without Torque on Lower Incisors: A Clinical Study
Authors: Shekatkar Yash K. , Ashith MV , Muddiah Sunil , Solanki Rainee , Bora Neelutpal , Haneesh K. PT , Bhat Ranjan 
Published: January 2025

ABSTRACT

Introduction:
The study aimed to evaluate the impact of the reverse curve of Spee in nickel-titanium (NiTi) wire both with and without torque on lower incisors.

Materials and Methods:
Twenty patients were divided into 2 groups. The inclusion criteria for the study were 1) age group between 12–25 years and 2) deepbite bite of 5–7 mm. All the subjects were treated with preadjusted edgewise brackets with Roth prescription for tip and torque values and a 0.022” slot. One group was treated with 0.019 × 0.025” Reverse curve NiTi (conventional) and the other group with 0.019 × 0.025” Pretorqued (200 labial root torque) reverse curve NiTi.

Results:
The findings of the current study indicated that the lower incisor inclination in the conventional reverse curve NiTi group was found to be proclined by a statistically significant value of 20. The lower incisor inclination in the 200 pretorqued reverse curve NiTi group was found to be retroclined by a statistically significant value of 20.

Conclusion:
The results of the study concluded that both conventional and pretorqued reverse curve Niti wires were efficient in bite opening. However, the incisor inclination among the 2 groups varied. There was a significant reduction in proclination of the incisors using 200 pretorqued reverse curve NiTi wire when compared with the conventional reverse curve NiTi.
Epidermal Ridge Patterns of Fingers in the Patients with Oral Premalignant Conditions-A Dermatoglypic Study
Authors: Sarkate Priyadarshani , Kale Manasi , Pawar Vipul M. , Dipke Komal B , Vaidya Supriya L 
Published: January 2025

ABSTRACT

Background:
Dermatoglyphics play an important role in the identification of a person as well as identifying a person with a genetic abnormality. Hence, the present study was conducted with an aim to explore the association between the fingerprint patterns and oral potentially malignant disorders (PMDs).

Materials and Methods:
We observed 80 individuals divided into 4 groups with 20 individuals in each group based on their habit and the presence of oral lesions. Group 1 included individuals with oral leukoplakia (OL), Group 2 included individuals with oral submucous fibrosis (OSMF), Group 3 individuals had tobacco habits but without lesion and Group 4 comprised of control individuals. The fingerprints of all the study subjects were recorded using a standard ink method. They were analyzed qualitatively and quantitively. It was observed that loop patterns was predominant in all the groups.

Result and Conclusion:
The frequency of the whorled pattern was higher in subjects with OSMF as compared to OL. The arch pattern was comparatively lesser in subjects with OL than OSMF subjects. We conclude that dermatoglyphics can be used as a potential marker to identify the subjects with risk for potentially malignant oral disorders.
Evaluation of Maxibloc Bone Grafts Biocompatibility and Osteoconductivity: An Animal Study
Authors: Joseph Suja , Jacob Jose , Joseph Angel M. , Kuriakose Rene , Mustafa Mohammed Z. , Yasodharan Venu , Dathan Pradeep C. , Rasheed Nazia 
Published: January 2025

ABSTRACT

Context:
Alveolar bone resorption poses a significant challenge in rehabilitating edentulous patients. Ridge augmentation materials can stimulate bone growth in deficient areas.

Aim:
To evaluate the biocompatibility and osteoconductivity of maxibloc bone grafts in rabbits.

Materials and Methods:
Maxibloc was packed into bony voids created surgically in the mandible and femur of rabbits, which were sacrificed at the fourth, eighth, and twelfth weeks. Radiography and histopathology evaluations assessed the osteoconductivity; hematology and toxicology evaluations assessed the biocompatibility of maxibloc.

Results:
Radiography revealed bone formation and homogenization without osteolysis. Histopathology revealed new bone formation with osteoblasts, fibrous and collagen tissue, cartilage formation, and no foreign body reaction or inflammation. Hematology revealed stable hemoglobin concentration, white blood cell count, eosinophil count, and absence of leucocytosis. Toxicology revealed elevated mortality rates at higher doses, whereas lower doses were safe. Animals exhibited no signs of systemic toxicity or behavioral changes.

Conclusions:
Maxibloc has demonstrated biocompatibility and osteoconductivity, presenting as a promising alloplastic bone graft.
Comparative Evaluation of the Impact of Chloride and Fluoride Based Electrolytes on PDL Cells Before and After Electrochemical Dissolution
Authors: Ramachandran Hariprasad , Kuriakose Feby , Joseph Shiny , Anoop V. N. , Thushar Balan K. 
Published: January 2025

ABSTRACT

Objective:
Most methods for retrieving fractured instruments have consequences that may affect treatment outcomes. A better outcome can be achieved with electrochemical dissolution without mechanical injury.

Materials and Methods:
Several electrochemical dissolution solutions are being used including artificial saliva, Tyrode’s solution, and sodium fluoride (NaF). These electrolytes were prepared and their respective electrochemical characterization was done before conducting the assay. The present in vitro study compares the possible cytotoxic effect and viability of periodontal ligament cells in artificial saliva, Tyrode’s solution, and NaF using an MTT assay.

Results:
The comparative analyses of the cell viability and toxicity effects of the electrolytes considered are reported. It was observed that the Artificial saliva (before dissolution: 84.10±11.32; after dissolution: 69.1±11.32) and Tyrode’s solution (before dissolution: 77.30±4.11; after dissolution: 61.3±4.11) showed higher cell viability percentages and comparatively reduced toxicity levels before and after dissolution compared to NaF (before dissolution: 36.01±5.27; after dissolution: 11.01±5.27). Statistical analysis of the results observed before and after dissolution provided a significant difference (P<0.05).

Conclusions:
The artificial saliva and the Tyrode’s solution may be considered as a potential electrochemical dissolution solution during the surgery to achieve a better outcome.
The GC MS Study of One Ayurvedic Formulation, Navayasa Churnam
Authors: Sudhan Aparna , Prabhu K. , Jones Sumathi , Janaki C. S. , Sheriff Dhastagir , Rao Mudiganthi R. , Kumar Muttevi H. , Balakrishnan Deepalakkshmi , Shresht M. 
Published: January 2025

ABSTRACT

Background:
Navayasa Churnam is an Ayurvedic medicine traditionally used to treat anemia, heart diseases, skin disorders, piles, and jaundice.

Aim:
The present study involves GC-MS analysis of Navayasa Churnam, an Ayurvedic medicine traditionally used to treat anemia, heart diseases, skin disorders, piles, and jaundice.

Methods:
The Churnam was sourced from a reputable Ayurvedic vendor in Chennai, India, and prepared according to standard protocols. The medicine was then analyzed to identify its bioactive compounds.

Results:
The GC-MS analysis revealed several key compounds, including Asarone, known for its sedative and antioxidant properties; 17-Octadecynoic acid methyl ester, with potential anti-inflammatory effects; n-Pentadecanol, recognized for its antimicrobial activity; and Chloroacetic acid pentadecyl ester, which may possess antiviral properties. Additional compounds identified include n-Butyl cinnamate, noted for its anti-inflammatory and antioxidant effects; Chloroacetic acid tetradecyl ester, which might offer antimicrobial benefits; and 2-ynyl o-anisate, known for its analgesic properties. Piperine, which enhances the bioavailability of other compounds and has anti-inflammatory effects, was also detected. Other notable compounds are Z-10-Methyl-11-tetradecen-1-ol propionate, Carnosic acid, and Ethyl iso-allocholate.

Conclusion:
The identification of these compounds supports the traditional therapeutic uses of Navayasa Churnam and underscores the importance of integrating modern analytical techniques with traditional knowledge to validate and enhance herbal remedies.
Open Sesame: A Comparative Evaluation of Parental and Dentist Perception on Various Mouth Props
Authors: LakshmiKumari K , Rajesh Kavitha , Megalaa N , Francis Nincy , Ranjith K , Manikandan K , Nagappan Nagappan , Sekar Gowrishankar 
Published: January 2025

ABSTRACT

Background:
The most commonly used adjunct on a cooperative child is the mouth prop. However, the design variation of the mouth props and the possible disadvantages make it difficult to select the appropriate mouth prop. Hence, this study was conducted to evaluate and compare the effectiveness and acceptance of custom-made mouth props with that of commercially available mouth props.

Aim:
To evaluate and compare the effectiveness and acceptance of custom-made mouth props with that of commercially available mouth props.

Methodology:
A custom-made mouth prop was fabricated that had added advantages of intraoral illumination and customized mouth opening and was used along with three commercially available mouth props on 10 children aged 4 to 10 years who required restorative procedures and were evaluated for their effectiveness based on the response given by the dentists and parents to the questionnaire provided to them. The results were evaluated using the Chi-square test.

Results:
The custom-made mouth prop was more acceptable when compared to other available mouth props owing to its property of intraoral illumination, customized mouth opening, and child-friendly design.

Conclusion:
The study results concluded that custom-made mouth props can be considered an effective adjunct for mouth opening.
Evaluating the Efficacy of Ozone Therapy and Low-Level Laser Therapy in Treating Premalignant and Malignant Lesions: A Systematic Review
Authors: Ranjitha E Gracelin , Sridhar Shruthi , Deepthi Angeline , Deepak J. John H. 
Published: January 2025

ABSTRACT

Introduction:
Premalignant lesions and conditions are comparably frequent, arising in less than 3% of the general public and a possible objective for cancer prevention. In a workshop conducted by WHO in 2005, the topic of discussion was “Oral lesion with a predisposition to malignant transformation”; thus, they proposed the term “Potentially Malignant Disorders [OPMDs]”. Therefore, patients evaluated with OPMDs may have an inclined vulnerability to develop lesion anywhere in their mouth during their lifetime. There are various treatment modalities in treating OPMDs, among which the looming and imminent treatment modality is “Laser therapy” using “Low level laser therapy [LLLT] and Ozone therapy”.

Aims and Objectives:
Evaluating the efficaciousness of LLLT and ozone therapy in treating OPMDs.

Methodology
This systematic review was performed using PRISMA guidelines. Systematic search of the literature was done with specific MESH keywords.

Results:
Based on the preformatted criteria, 12 articles were scrutinized and critically analyzed in the PICO format. Therefore, LLLT and ozone therapy have proven to be beneficial in treating premalignant lesions.

Conclusion:
Various treatment modalities exist in treating OPMDs; one of the less ventured and yet promising modalities is laser irradiation using LLLT and ozone therapy.
Flourescent Based Camera (QSCAN Plus) for Dental Plaque Quantification: Validation and Reliability
Authors: Panigrahi Antarmayee , Pattanaik Snigdha , Mohammad Noorjahan , Patnaik Swati , Sahoo Subhrajeet N. , Sarangi Debarchita 
Published: January 2025

ABSTRACT

Introduction:
Detection and quantification of dental plaque is crucial in both clinical dentistry and research. Established clinical indices used to measure dental plaque have limitations. The aim of the study was to evaluate the reliability and validity of plaque quantification using a fluorescent camera (QScan Plus).

Materials and Methods:
Double doubleblind study was carried out on 20 children of age ranging from 9 to 14 yrs. Plaque measurement was performed by two examiners on a total of 160 incisors at the base, 24, 36, 48, and 96 hrs. Images were captured by the fluorescent camera, digitally analyzed, and scored. Another scoring was done using Addy Plaque Index area after plaque disclosure. The average scores were used for statistical analysis.

Results:
The results were within the excellent reliability category for interoperator and intraoperator repeatability.

Conclusion:
This new system provides an improved objective method of quantifying dental plaque areas with increased accuracy.
Efficacy of Non-Pharmacological Interventions for Managing Restless Leg Syndrome in Hemodialysis Patients: A Quasi-Experimental Study in South India
Authors: Angelina Kirubakaran Amutha , Vaithilingan Sasi , Panneerselvam P 
Published: January 2025

ABSTRACT

Background:
This study investigates the efficacy of non-pharmacological therapies in treating restless leg syndrome (RLS), a neurological condition causing discomfort and sleep disruption, with India potentially leading the way in the coming years.

Methodology:
The study used a quasi-experimental design at the Abirami Kidney Center in Karur, screening 72 hemodialysis patients, 30 of whom had RLS. Fifteen samples were allocated for the study group and 15 for the control group, and interventions were administered to the study group.

Results:
The study found significant differences in symptoms, quality of life, and sleep levels among the experimental group compared to the control group. Effleurage massage therapy, foot reflexology, and IEC on sleep hygiene were found to improve sleep quality, reduce RLS symptoms, and enhance hematolysis patients’ quality of life.

Conclusion:
This feasibility study’s results could guide larger-scale trials and offer valuable insights into the effectiveness of non-pharmacological interventions in managing RLS.
Book Review: From Divided Pasts to Cohesive Futures: Reflections on Africa
Authors: Teshome Emana  
Published: January 2025

Book Title: From Divided Pasts to Cohesive Futures: Reflections on Africa
Authors': Hiroyuki Hino, Arnim Langer, John Lonsdale, and Frances Stewart (Eds.).
Publisher: Cambridge University Press: Cambridge,
Year of publication: 2019
Pages: 447 PP.
ISBN 978-1108476607
Male Seasonal Migration and Left-Behind Women: The Case of Guagusa Shekudad Woreda, Ethiopia
Authors: Zemenu Temesgen  , Getachew Senishaw  , Guday Emirie  
Published: January 2025

This study was aimed at analysing the consequences of men’s seasonal labour migration on left-behind women in Guagusa Shekudad Woreda, Awi Zone, Amhara Region of Ethiopia. The study employed primary and secondary data sources. Primary data were collected through a combination of qualitative- ethnographic research methods involving in-depth interviews, focus group discussions, participant observation, and informal conversation. The ethnographic data were thematically organised and analysed by triangulating the various data sources to maintain the reliability and validity of the study findings. The study's findings showed that husbands' seasonal labour migration has empowering effects on the left-behind wives, leading to enhanced decision-making authority and improved socio-economic standing. Furthermore, the study indicated that husbands' seasonal migration influences the customary gender based division of labour within migratory households. In this particular context, the agricultural activities performed by the wives left behind expand to include tasks typically associated with men in society. This, in turn, generates a multitude of responsibilities and stress for the wives who are left behind. Overall, the study indicates that men's seasonal labour migration has both beneficial and detrimental effects on the women they leave behind. Nevertheless, the positive outcomes of men's seasonal work surpass the negative outcomes.
Exploring the Challenges, Opportunities, and Stakeholders' Role in Community-Based Ecotourism Development in Kalash Valleys, Pakistan
Authors: Khan Karim Ali , Korcharoen Mon , Kun Liu , Lu Liangyan 
Published: January 2025

Objectives: This study aims to evaluate the opportunities, challenges, and crucial roles of stakeholders in the development of community-based ecotourism (CBET) in Kalash Valley, Chitral, Pakistan. It focuses on assessing the contributions of stakeholders, including local communities, government bodies, non-governmental organizations, and tourists, in promoting community participation, environmental conservation, and visitor satisfaction.

Methods: The study employs qualitative research methods, including semi-structured interviews with key stakeholders from the local community, to gather in-depth insights into their roles and contributions to CBET development.

Results: The findings reveal the availability of facilities, natural and cultural resources, challenges, and the significant roles of stakeholders in achieving sustainable CBET development. The collective efforts of stakeholders are essential for the successful implementation of community-based ecotourism management (CBETM).

Conclusion: The study underscores the importance of policymakers and local communities in enhancing environmental knowledge and actively participating in CBET management. It highlights the benefits of involving local communities in environmental planning to ensure conservation and lays the foundation for future research on CBET development, encouraging sustainable practices among communities and tourists.
Knowledge and Perception of Liver Cancer in Rural and Peri-Urban Areas of Vehari District
Authors: Naseer Muzammil , Tee Mcxin , Lu Liangyan , You Li 
Published: January 2025

Objectives: This study aims to empirically analyze the knowledge and perception of liver cancer in rural and peri-urban areas of Vehari district. It seeks to examine how various factors, such as knowledge about Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV), age, education level (above matriculation), and efforts to improve health, influence awareness about liver cancer.

Methods: The study employs SPSS to perform a comparative analysis of rural and peri-urban areas in the Vehari district. Binary logistic regression is used to estimate the relationship between the dependent variable—knowledge about liver cancer (measured as a categorical or binary variable)—and the explanatory variables, including knowledge about HCV and HBV, age, education level, and health improvement.

Results: The findings reveal that age has a negative impact on knowledge about liver cancer, indicating that younger individuals are more likely to have greater awareness. Knowledge about HCV and HBV has a positive and significant influence on awareness of liver cancer. Additionally, while education above matriculation shows a positive trend, its impact on liver cancer knowledge is statistically insignificant.

Conclusion: The study concludes that knowledge about HCV and HBV plays a critical role in enhancing awareness of liver cancer, while age negatively affects this awareness. The insignificant impact of higher education levels highlights the need for focused awareness campaigns to improve understanding of liver cancer in rural and peri-urban areas.
Performance and Equity in the 100-Meter Sprint: Contributions to Healthy and Inclusive Athletic Development
Authors: Valunpion Athiti , Rangubhet K. Ravivuth 
Published: January 2025

Objectives: This research aims to analyze and compare the running patterns and performance dynamics of athletes in six major international competitions, focusing on biomechanical and statistical aspects of the 100-meter sprint to enhance inclusivity and equity in athletics.

Theoretical Framework: Grounded in principles of biomechanics and sports science, this study investigates the role of body posture, step frequency, and arm swing in sprint performance, linking them to sustainable development in sports.

Method: Data were collected from six competitions, including the Olympic Athletics (2012, 2016, 2020) and World Championship Athletics (2015, 2017, 2019). Statistical analyses, including descriptive statistics and independent samples t-tests, were employed to identify significant differences in sprinting techniques.

Results and Discussion: Key findings reveal a preference for the Banzai starting technique (37.8%) in Olympic events, with specific biomechanical patterns such as dominant hand positioning equal to shoulder width (51.1%) and hip elevation above shoulder level (64.4%). Sprinting dynamics vary significantly, with body posture transitioning from forward inclination at 30m (57.8%) to upright at 60m (77.8%) and back to forward inclination at 100m (80%). The fastest segment, 30-60m, exhibits the least frequent steps (12.73±0.81) and arm swings (12.82±0.09), with significant differences observed between Olympic and World Championship settings.

Research Implications: These findings provide actionable insights for coaches and athletes to refine sprinting strategies, emphasizing the importance of biomechanics in optimizing performance and fostering equitable opportunities in athletics.

Originality/Value: This study contributes to sustainable sports development by integrating evidence-based biomechanical practices with a focus on inclusivity, equity, and performance optimization in elite sprinting competitions.