bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inpatient satisfaction survey based on national standard satisfaction questionnaire conducted in a tertiary hospital in Shenyang, China
Authors: Xintong Zhou , Moriyama Michiko , Tao Xin , Shuying Wang , Huiying Gao 
Published: February 2024

Abstract
Background In 2019, China released its first standardized patient satisfaction survey questionnaire and conducted a nationwide survey. However, due to significant developmental disparities among regions, the applicability of this national standard questionnaire remains unverified at the individual healthcare institution level. Furthermore, previous satisfaction studies often focused on influencing factors, with limited exploration into the relationships between these factors and their roles. This study aims to validate the national standard satisfaction questionnaire in a tertiary general hospital in Northeast China. Utilizing the questionnaire's inherent structure, the research investigates factors influencing inpatient satisfaction and explores the relationships and determinative roles of these factors.
Method This research employed a cross-sectional survey, utilizing the national standard satisfaction questionnaire, at a tertiary comprehensive hospital in Shenyang, Northeast China. The survey links were distributed through short message service (SMS) to inpatients between April and July 2022, with participation being voluntary. A total of 850 responses were gathered, resulting in a response rate of 5.51%.
Result The results of the Confirmatory Factor Analysis (CFA) demonstrate a well-fitting model for the questionnaire (c2/df = 2.931). Factors such as “Doctor communication”, “Medicine information”, “Discharge instructions”, “food”, and “medical staff’s attitudes towards patients’ visitors” emerged as significant influencing factors of inpatient satisfaction (all, p < 0.05). Additionally, “Gender” and Activities of Daily Living (ADL) level impacted patient satisfaction levels (both, p < 0.001) . Further Chi-squared Automatic Interaction Detector (CHAID) analysis indicates that the key determinants of variations in patient satisfaction are ADL level and "Medication Information"(both, p < 0.001) .
Conclusion The satisfaction level in hospitals is primarily determined by the communication skills between doctors and patients, and it could be enhanced by providing professional assistance to patients with higher activities of daily living (ADL) levels and offering comprehensive information about medicines to all patients. Satisfaction levels exhibit baseline variations among different populations, such as males and females. The involvement of family caregivers has impacted the structure of the satisfaction model, along with various other aspects.
Group-related phenomena in Wikipedia edits
Authors: Burgess M. , Dunbar R. I.M. 
Published: February 2024

Abstract
Human communities have self-organizing properties that give rise to very speci c natural
grouping patterns, reected in the Dunbar Number and its layered structure (a Dunbar
Graph). Since work-groups are necessarily also social groups, we might expect the same
principles to apply here as well. One factor likely to be important in limiting the size of
groups is that conicts typically escalate with the number of people involved. Here we
analyse Wikipedia editing histories across a wide range of topics to show that there is an
emergent coherence in the size of groups formed transiently to edit the content of subject
texts, with two peaks averaging at around N = 8 for the size corresponding to maximal
contention, and at around N = 4 as a regular team. These values are consistent with the
observed sizes of conversational groups, as well as the hierarchical structuring of Dunbar
graphs. We use the Promise Theory of trust to suggest a scaling law that may apply to all
group distributions based on seeded attraction. In addition to providing further evidence
that even natural communities of strangers are self-organising, the results have important
implications for the governance of the Wikipedia commons and for the security of all online
social platforms and associations.
Determinants of Digital Technology Development in Sub-Saharan African Countries; Evidence from Panel Data Analysis
Authors: Beyene Elfenesh , Bedemo Amsalu , Gebremeskel Atnafu 
Published: February 2024

Abstract
The primary objective of this research is to explore the elements that shape the progression of digital technology in Sub-Saharan African nations. The study employs data obtained from 16 countries, covering the period between 2000 and 2020. Employing fixed effect panel regression analysis, our research indicates that various non-technological factors significantly impact digital technology development in the region. The results highlight that variables including general government final consumption expenditure, inflation rate, employment growth rate, financial development, ease of doing business index, logistics performance index, international migration, access to electricity, and access to safe drinking water have a positive impact on the development of digital technology. Conversely, international trade is identified as a negative influence, primarily due to insufficient infrastructural development. These findings underscore the significance of non-technological elements, encompassing aspects like globalization, economic conditions, favorable digital ecosystems, and the fulfillment of basic human needs, in shaping the landscape of digital technology in the region. The study, while acknowledging limitations in terms of selected indicators, years, and countries, emphasizes the need for broader investigations in future research. Practically, the study suggests that governments in the region should prioritize addressing these non-technological factors to fully leverage the potential of digital technology development. The originality and value of this research lies in its exploration of non-technological determinants, shedding light on their pivotal role in shaping the digital technology landscape in Sub-Saharan Africa
Gender differences in cognitive function of children with ADHD based on the Das-Naglieri Cognitive Assessment System
Authors: Lian Qiongxia , Qin Zixi , Li Dandan , Tan Xiaoying , Liu Hairun , Fu Yanhong , Yang Lixian 
Published: February 2024

Abstract
Background:Attention deficit hyperactivity disorder (ADHD) is a neuro-developmental disorder with a relatively high prevalence. Due to the significant difference in incidence between males and females, gender has been used as an important factor in the study of ADHD. This study aimd to explore the gender difference in the cognitive function of children with ADHD using the Das-Naglieri Cognitive Assessment System (DN: CAS).
Methods: This study recruited 210 ADHD children as the test group and 118 healthy children as the control group. The gender ratio in each group was 1:1 with same age and grades. The DN: CAS was assessed in both groups.
Results: A comparison of sex differences within the ADHD group revealed that boys'performance in Planning was better than that of girls (p=0.018),while the ADHD boys received lower scores in Verbal-Spatial Relations,Sentence Repetition, and Attention than that of girls (P=0.015,0.033,0.031).
Only boys in the ≥9 year of age ADHD group received higher scores in Planning than that of girls in the same age range (p=0.031), gender differences were not found in the <9 year of age ADHD group and the control group. While only Boys in the <9 years of age ADHD group perform worser in Simultaneous Processing than that of girls in the same age range(p=0.045), gender differences were not found in the ≥9 year of age ADHD group and the control group.
Conclusion: Gender differences exist in cognitive function of children with ADHD.The DN: CAS can provide significant evidence of the weakness of ADHD girls in Planning tasks with acceptable sensitivity. This gender difference is related to age. The DN: CAS can identify gender differences in cognitive function among children with ADHD at various ages and assist clinicians in identifying girls with ADHD who have less pronounced externalizing symptoms.
Staphylococcus aureus colonization and prevalence of skin and soft tissue infections among people who inject drugs – a longitudinal study
Authors: Jörgensen Jimmy , Dahlman Disa , Blomé Marianne Alanko , Janson Håkan , Riesbeck Kristian , Nilsson Anna C. 
Published: February 2024

Abstract
People who inject drugs are frequently colonized with Staphylococcus aureus and have an increased risk for skin and soft tissue infections. This longitudinal study aims to describe S. aureus colonization in this group and the risk for infections during a one-year follow-up. We included 61 participants from the Malmö Needle Exchange Program. Mapping of S. aureus colonization was conducted by screening cultures every third month and S. aureus growth was semi-quantified. Data regarding infections and living conditions were collected from structured interviews. Statistics included univariate analysis with the Fischer’s exact test, univariate logistic regression and multivariate logistic regression. S. aureus colonization was detected in 46–63% of participants, and 75% reported one or more infections during the study period. Self-reported infections were associated with colonization in perineum (OR 5.08 [95% CI 1.45–17.73]), in skin lesions (OR 1.48 [95% CI 1.21–1.81]), and unstable housing situation (OR 12.83 [95% CI 1.56-105.81]). Thus, people who inject drugs are frequently colonized with S. aureus and report a surprisingly high prevalence of skin and soft tissue infections. Homeless people and those with skin colonization seem to be at highest risk. Effective clinical interventions are needed, aiming at preventing infections in this vulnerable group.
Iron Overload Promotes Hemochromatosis-Associated Osteoarthritis via the mTORC1-p70S6K/4E-BP1 Pathway
Authors: Fang Zhiyuan , Wang Chengwei , Zhu Jiang , Yang Gou Yang 
Published: February 2024

Abstract
Joint iron overload in hemochromatosis induces M1 polarization in synovial macrophages, releasing pro-inflammatory factors and leading to osteoarthritis development. However, the mechanism by which iron overload regulates M1 polarization remains unclear. This study aims to elucidate the mechanism by which synovial iron overload promotes macrophage M1 polarization. Cell morphology, Prussian blue staining, qPCR, WB, ELISA, HE staining, saffranine O-staining and immunohistochemical analysis were performed. In vitro, iron-treated macrophages exhibited Prussian Blue staining indicative of iron overload and morphological changes towards M1 polarization. qPCR and Western Blot revealed increased expression of the M1 polarization markers iNOS and its protein. ELISA showed elevated TNF-α and IL-6 levels in supernatants. In vivo, ferrozine assay indicated significantly increased serum iron concentrations in all groups except A-Ctrl; Prussian Blue staining showed increased liver iron deposition in all groups except A-Ctrl. Iron deposition in rat synovium decreased in a DFO concentration-dependent manner; immunohistochemistry showed a corresponding decrease in iNOS and phosphorylated 4E-BP1 expression, and an increase in Arg-1 expression. Intracellular iron overload may exacerbate joint cartilage damage by promoting synovial macrophage M1 polarization through phosphorylation of 4E-BP1 in the mTORC1-p70S6K/4E-BP1 pathway.
Injuries induced by Recreational Activities in Older Adults: a CHIRPP Database Study
Authors: Joyal Rose , Gagnon Ann-Pier , Benhamed Axel , Blanchard Pierre-Gilles , Dubucs Xavier , Sirois Marie-Josée , Emond Marcel , Carmichael Pierre-Hugues , Mercier Eric 
Published: February 2024

Abstract

Background
Older adults are more active than before with rising participation in sports and recreational activities. However, despite this trend, sports-induced injuries and their outcomes in older adults are insufficiently described.
Objectives
To describe the characteristics, clinical care, outcomes, and disposition of older adults attending the emergency department (ED) for a traumatic injury sustained during recreational activities. The secondary objective was to explore the impact of trauma mechanism.
Methods
All patients aged 60 years and older presenting to the ED of three university-affiliated hospitals for a recreational injury were included. Data were collected systematically through the Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP) sentinel surveillance system. All recreational activities and sports included in the CHIRPP database were classified into ten categories.
Results
A total of 1982 older adults were included (mean age: 68.5 (SD 6.89), females: 39.5%). The most common recreational activities and sports associated with injuries requiring ED consultation were cycling (42.3%), followed by skiing and snowboarding (16.8%), hockey and ice sports (11.0%) and motorized vehicles activities (7.9%). The most frequent body parts injured were upper limbs (38.9%), lower limbs (28.2%) and head (26.3%). Approximately one in five patients required hospitalization (21.6%).
Conclusion
The older population is engaging in activities historically associated with younger individuals. Injuries sustained during cycling, skiing and motor vehicle recreational activities are particularly frequent in older population attending EDs. Adapting ED care and prevention strategies for this population is essential.
Characteristics and critical care interventions in drowning patients treated by the Danish Air Ambulance from 2016-2021: a nationwide registry-based study with 30-day follow-up
Authors: Breindahl Niklas , Wolthers Signe Amalie , Møller Thea Palsgaard , Blomberg Stig Nikolaj Fasmer , Steinmetz Jacob , Christensen Helle Collatz , NA the Danish Drowning Validation Group 
Published: February 2024

Abstract
Background Improving oxygenation and ventilation in drowning patients early in the field is critical and may be lifesaving. The critical care interventions performed by physicians in drowning management are poorly described. The aim was to describe patient characteristics and critical care interventions with 30-day mortality as the primary outcome in drowning patients treated by the Danish Air Ambulance.Methods This retrospective cohort study with 30-day follow-up identified drowning patients treated by the Danish Air Ambulance from January 1, 2016, through December 31, 2021. Drowning patients were identified using a text-search algorithm (Danish Drowning Formula) followed by manual review and validation. Operational and medical data were extracted from the Danish Air Ambulance database. Descriptive analyses were performed comparing non-fatal and fatal drowning incidents with 30-day mortality as the primary outcome.Results Of 16,841 dispatches resulting in a patient encounter in the six years, the Danish Drowning Formula identified 138 potential drowning patients. After manual validation, 98 drowning patients were included in the analyses, and 82 completed 30-day follow-up. The prehospital and 30-day mortality rates were 28% and 67%, respectively. The National Advisory Committee for Aeronautics (NACA) severity scores from 4–7, indicating a critical emergency, were observed in 90% of the total population. They were significantly higher in the fatal vs non-fatal group (p < 0.01). At least one critical care intervention were performed in 68% of all drowning patients, with endotracheal intubation (62%), use of an automated chest compression device (41%), and intraosseous cannulation (39%) as the most frequently performed interventions. More interventions were generally performed in the fatal group (p = 0.01), including intraosseous cannulation and automated chest compressions.Conclusions The Danish Air Ambulance rarely treated drowning patients, but those treated were severely ill, with a 30-day mortality rate of 67% and frequently required critical care interventions. The most frequent interventions were endotracheal intubation, automated chest compressions, and intraosseous cannulation.
Quantitating the Summer Moisture Sources over Northwest China and Its Annual Variations in Dry and Wet years
Authors: Zhu Bin , Qian Peng , Zhu Tong , Fang Chenwei , Lu Chunsong , Chen Haishan , Liao Hong 
Published: February 2024

Abstract
The Northwest China (NWC) is located in an arid and semi-arid inland region, making its ecosystem highly vulnerable to changes of precipitation. Previous studies have revealed the wetting trend and potential moisture sources of the NWC, while not clearly quantified the moisture (water vapor and precipitation) sources and its interannual variability. Here, by performing and analyzing CAM5.1 simulation for 40 years, with a coupled atmospheric water tracer (AWT) algorithm, we find that the dominant sources of summer moisture over NWC are from terrestrial sources (82% of vapor and 77% of precipitation), i.e. from the North Asia (NA), Europe (EUP), southern Tibetan Plateau (STP), and southeastern China (SEC), rather than the oceanic sources. Due to the influence of synoptic patterns, the precipitation-conversion efficiency of water vapor from the southwestern airflow (STP and SEC) is higher than that from the northwestern airflow (NA and EUP). We also find that despite a general increasing trend in humidification, the fluctuation from relatively dry to wet years still persists in the NWC mainly influenced by the increased transport of moisture from terrestrial sources (NA and STP).
In a stranger's house: social isolation of internally displaced persons in war times
Authors: Tsybuliak Natalia , Popova Anastasiia , Lopatina Hanna , Suchikova Yana 
Published: February 2024

Abstract
This article explores the impact of internal displacement during wartime in Ukraine on individuals' social isolation. This study focused on understanding and comparing feelings of isolation in two different contexts: the native community in territories temporarily occupied by Russian troops since the full-scale war and the host community. The research reveals a consistent pattern of isolation characterized by feelings of loneliness, anxiety, and emotional exhaustion among internally displaced persons, irrespective of their location. Cultural disconnection emerges as a significant factor in both settings, with war-induced changes in social norms and practices leading to a sense of alienation in native communities, and the challenge of adapting to new cultural environments in host communities. This study highlights the difficulties faced by IDPs in building new social networks and the added complexity of emotional exhaustion caused by the ongoing war. It also underscores the heightened vulnerability of IDPs to bias, stigma and anxiety in social interactions. Overall, this qualitative study advances the understanding of the effects of displacement on social isolation and provides insights that can inform effective recovery strategies and foster of a resilient, cohesive national identity in post-war contexts in Ukraine.
FAN1-mediated translesion synthesis and POLQ/HELQ-mediated end joining generate interstrand crosslink-induced mutations
Authors: Tijsterman Marcel , Verschuren Jip , Schendel Robin van , Bostelen Ivo van , Knipscheer Puck 
Published: February 2024

Abstract
DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and transcription and therefore are extremely cytotoxic. To counteract these effects cells evolved various specialized ICL repair pathways. The division of labor between these routes, and the extent to which repair impact on genetic integrity is, however, still poorly understood. Here, we have determined the mutagenic consequences of ICL repair in the animal model C. elegans. Plasmids containing a single, site-specific, psoralen crosslink were injected into the worm’s gonad, after which targeted sequencing of transgenic progeny animals was conducted to establish repair profiles. Through genetic dissection we identified two mechanisms by which psoralen ICLs induce genetic change: i) translesion synthesis through POLH and REV1/3-mediated bypass, giving rise to single nucleotide polymorphisms (SNVs), and ii) end joining through POLQ or HELQ action leading to deletions. Whilst we found no role for the Fanconi anemia genes FANCD2 and FANCI in causing nor suppressing these deletions, disruption of C. elegans TRAIP, which triggers the unloading of the CMG helicase at sites of blocked replication, resulted in a strikingly altered repair profile, arguing for a role for DNA replication in the aetiology of ICL-induced deletions. Translesion synthesis products were not affected by TRAIP deficiency. Instead, we found SNVs induced at ICLs to depend on the functionality of the Fanconi anemia-associated nuclease FAN1.
Combined Treatment of Ketogenic Diet and Propagermanium Reduces Neuroinflammation in Tay-Sachs Disease Mouse Model
Authors: İnci Orhan Kerim , Seyrantepe Volkan 
Published: February 2024

Abstract
Tay-Sachs disease is a rare lysosomal storage disorder caused by β-hexosaminidase A enzyme deficiency causing abnormal GM2 ganglioside accumulation in the central nervous system. GM2 accumulation triggers chronic neuroinflammation due to neurodegeneration-based astrogliosis and macrophage activity with the increased expression level of Ccl2 in the cortex of a recently generated Tay-Sachs disease mouse model Hexa-/-Neu3-/-. Propagermanium blocks the neuroinflammatory response induced by Ccl2, which is highly expressed in astrocytes and microglia. The ketogenic diet has broad potential usage in neurological disorders, but the knowledge of the impact on Tay-Sach disease is limited. This study aimed to display the effect of combining the ketogenic diet and propagermanium treatment on chronic neuroinflammation in the Tay-Sachs disease mouse model. Hexa-/-Neu3-/- mice were placed into the following groups: (i) chow diet, (ii) ketogenic diet (iii) chow diet with propagermanium, and (iv) ketogenic diet with propagermanium. Neuroinflammation markers were analyzed by RT-PCR and immunohistochemistry. Behavioral analyses were also applied for the assessment of phenotypic improvement. Notably,the expression levels of neuroinflammation-related genes were reduced in the cortex of 140-day-old Hexa-/-Neu3-/- mice compared to β-hexosaminidase A deficient mice Hexa-/- after combined treatment. Immunohistochemical analysis displayed correlated results with the RT-PCR. Our data suggest the potential to implement combined treatment to reduce chronic inflammation in Tay-Sachs and other lysosomal storage diseases.
The Longitudinal Assessment of Prenatal Cannabis Use on Neonatal Outcomes
Authors: habersham Leah , Hurd Yasmin , Nomura Yoko 
Published: February 2024

Abstract

Objective
Investigate the association between prenatal cannabis use and neonatal outcomes using longitudinal data from pregnant individuals.
Study Design
Data was leveraged from the Stress in Pregnancy longitudinal study, conducted between 2009 and 2013. Interviews and electronic medical records of 894 pregnant individuals were analyzed, with 791 identified as using cannabis. Cannabis use and neonatal outcomes (NICU admission, preterm delivery, low birth weight, fetal death) were investigated.
Results
Among participants analyzed, 13.1% used cannabis, who were generally younger (25.9 vs 27.9 years). Unadjusted analysis indicated a seven-fold increased risk of fetal death (OR 7.30) with cannabis, which persisted after adjustments (aOR 6.31). Adjusted models also suggested increased low birth weight risk (aOR 1.67).
Conclusion
This study highlights an association between prenatal cannabis use and elevated risks for fetal death and low birth weight.
Funding Support: NIH T32HL160513, NIDA R25DA033211, NIDA R01DA057310, Addiction Institute of Mount Sinai internal funds