bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient Near‐Infrared Light‐Emitting Diodes Based on CdHgSe Nanoplatelets
Authors: Prudnikau Anatol , Roshan Hossein , Paulus Fabian , Martín‐García Beatriz , Hübner René , Bahmani Jalali Houman , De Franco Manuela , Prato Mirko , Di Stasio Francesco , Lesnyak Vladimir 
Published: November 2023

AbstractCadmium mercury selenide (CdHgSe) nanocrystals exhibit a unique combination of low‐energy optical absorption and emission, which can be tuned from the visible to the infrared range through both quantum confinement and adjustment of their composition. Owing to this advantage, such nanocrystals have been studied as a promising narrow‐band infrared light emitter. However, the electroluminescence of CdHgSe‐based nanocrystals has remained largely unexplored, despite their potential for emitting light in the telecom wavelength range. Further benefits to their optical properties are expected from their shape control, in particular the formation of 2D nanocrystals, as well as from a proper design of their heterostructures. In this work, a colloidal synthesis of CdHgSe/ZnCdS core/shell nanoplatelets (NPLs) starting from CdSe template NPLs employing a cation exchange strategy is developed. The heterostructures synthesized exhibit photoluminescence that can be tuned from ≈1300 to 1500 nm. These near‐infrared‐active NPLs are employed in light‐emitting diodes, demonstrating low turn‐on voltage and high external quantum efficiency.
CoOx‐Caged Metal‐Organic Frameworks for Sonocatalyzing CO2 to Co for Ultrasound‐Assisted Chemodynamic‐Gas Cancer Therapy
Authors: Zhang Tian , Zheng Qiang , Huang Jie , Li Xiang 
Published: November 2023

AbstractCarbon monoxide (CO) as an endogenous gaseous signaling molecule, is widely studied for its ability to inhibit cancer cell proliferation as gas therapy. However, the therapeutic efficiency of CO gas therapy is far from ideal due to the low availability of CO supply. Here, inspired by the band structure and Fenton‐related elements, MIL‐101(Cr)@CoOx nanoparticles are introduced for the first time to achieve ultrasound‐mediated synergistic therapy by combining CO gas therapy and chemodynamic therapy together effectively. MIL‐101(Cr)@CoOx can present substantial CO2 adsorption capacity for the BDC2− linkers and Co center, and enable to transformation of endogenous CO2 to CO efficiently under ultrasound irradiation due to the appropriate band structure and conduction band position. With the Co‐engaged Fenton‐like reaction, MIL‐101(Cr)@CoOx triggered the reactions to catalyze the over‐expressed intracellular H2O2 into cytotoxic hydroxyl radicals (·OH). The potential therapeutic outcome of chemodynamic therapy can be amplified by the ultrasonic cavitation‐induced conversion between Co3+ and Co2+ in vitro is demonstrated. The proliferation, ATP, and mitochondria functions of 4T1 mouse breast cancer cells are severely compromised by CO‐promoted ROS generation and the sono‐Fenton effect. Further, in vivo studies confirm that MIL‐101(Cr)@CoOx combined with ultrasound irradiation exhibits superior tumor suppression, and achieves the ultrasound‐mediated chemodynamic‐gas cancer therapy with higher precisions for personalized treatments. This new system offers a distinct concept for constructing smart ultrasound‐stimulus systems to realize synergetic cancer therapy.
Unraveling the Morphology‐Function Correlation of Mesoporous ZnO Films upon Water Exposure
Authors: Tian Ting , Tu Suo , Xu Ang , Yin Shanshan , Oechsle Anna Lena , Xiao Tianxiao , Vagias Apostolos , Eichhorn Johanna , Suo Jinping , Yang Zhangcan , Bernstorff Sigrid , Müller‐Buschbaum Peter 
Published: November 2023

AbstractUbiquitous moisture in synthetic conditions and ambient environments can strongly influence the conductivity of ZnO semiconductors via the chemisorption and physisorption of water molecules on the ZnO surface. Such an intrinsically water‐sensitive nature will become more evident in mesoporous ZnO films where a large surface area and active sites are created simultaneously. However, fundamental insights underlying water‐mediated ZnO surface chemistry and electrical conductivity and the factors affecting them remain ambiguous due to the complexity of ZnO surfaces and the difficulties of in situ characterizations at multi‐dimensions. Here, self‐assembling diblock copolymers are exploited as structure‐directing agents to achieve mesoporous ZnO thin films with highly tailorable structural characteristics ranging from nanomorphologies, over crystalline levels, to defect contents. As verified by theoretical calculations, the presence of oxygen vacancy will facilitate favorable water adsorption and subsequent dissociation on the polar ZnO surfaces. Upon humidity exposure with progressively increased levels, mesoporous ZnO films are revealed to follow an almost positive relationship between adsorption and electrical conductivity but show superior morphological stability. This work not only elucidates the water‐governed ZnO surface chemistry but may also promote a comprehensive understanding of the morphology‐function relationship on ZnO‐based electronics.
Efficiency Improvement of Energy Harvesting Device Using Light Pressure Through Plasmon Coupling at the Interface Between Grained Ag Layer and Au Nanoparticles
Authors: Jang Jun‐Hyeon , Lee Ha Young , Ryu Jae‐Hoon , Lee Jeong‐Yeon , Kim Sung‐Hyun , Hwang Sun‐Lyeong , Ahn Hyung Soo , Ha Dong Han , Yi Sam Nyung 
Published: November 2023

AbstractElectricity generation using the piezoelectric effect is an important energy harvesting method. In this study, a solar radiation pressure‐driven crater‐shaped light pressure electric generator (LPEG) device with a Pb(Zr0.52, Ti0.48)O3 (PZT) piezoelectric layer and grained Ag layer is fabricated on GaAs(100) wafer. The electrical output of the device is improved by adsorbing Au nanoparticles (AuNPs) on the Ag layer with the surface of closely connected Ag nanoparticles (AgNPs). By controlling the size and concentration of the AuNPs, a maximum power density of 867.5 µW cm−2 is obtained under a solar simulator (AM 1.5G), which represents a 151.7% improvement over the case without AuNP adsorption. The results of Raman spectra, finite‐difference time‐domain (FDTD) simulations, and COMSOL Multiphysics demonstrate that the newly formed hotspots between AgNPs─AuNPs and AuNPs─AuNPs enhance the electric field of the incident light significantly and extend the region where the electric field is maximally amplified to 600–800 nm, resulting in increased solar radiation pressure on the PZT piezoelectric layer.
Primary and Secondary Amines by Flavin‐Photocatalyzed Consecutive Desulfonylation and Dealkylation of Sulfonamides
Authors: Pavlovska Tetiana , Weisheitelová Ivana , Pramthaisong Chiranan , Sikorski Marek , Jahn Ullrich , Cibulka Radek 
Published: November 2023

AbstractAlkane‐, arene‐, and perfluoroalkanesulfonyl groups are widely used in organic synthesis to protect amino functionalities or to facilitate their installation. Protection of amino functions by a sulfonyl group to form sulfonamides is advantageous as they are easy to purify and tolerate various reaction conditions. On the other hand, sulfonyl group removal is difficult. Herein, we present a versatile metal‐free photocatalytic reductive method for desulfonylation of sulfonamides and aryl sulfonates to the parent amines mediated by flavin derivatives, namely deazaisoalloxazines and deazaalloxazines, and visible light. Photocatalysis with 5‐deazalloxazines is shown to even mediate the cleavage of perfluoroalkanesulfonamides (triflylamides and nonaflylamides), which is significantly more difficult than that of other sulfonamides and has previously not been achieved by photochemical means. The method is shown to perform consecutive desulfonylation and dealkylation of N‐alkyl‐N‐phenylperfluoroalkanesulfonamides affording primary anilines. This occurs via consecutive reductive and oxidative catalytic cycles mediated by the flavin catalyst. The perfluoroalkylsulfonyl group fulfils a dual role serving as a protecting group and, after removal by the reductive cycle, as the species driving the oxidative dealkylation reaction.
Identification of Selected Persistent Organic Pollutants in Agricultural Land by Carbon Nitride (C3N5) Based Nano Sensors
Authors: Panigrahi Puspamitra , PS Anuroop , Lee Hoonkyung , Bae Hyeonhu , Kaewmaraya Thanayut , Pandey Ravindra , Hussain Tanveer , Panigrahi Akshaya 
Published: November 2023

AbstractEfficient detection of selected persistent organic pollutants (POPs) is extremely important for the safety of humans and for the moderation of agriculture. This calls for the design of versatile nanosensors capable of sensing toxic POPs with high sensitivity and selectivity. Inspired by this, the sensing characteristics of carbon nitride (C3N5) monolayers toward selected POPs are reported, such as Dichlorodiphenyltrichloroethane (DDT), Methoxychlor (DMDT), Fenthion (FT), Fenitrothion (FNT), and Rennol (RL), employing density functional theory calculations. Analysis of results predicts adsorption energies of −0.93, −1.55, −1.44, −0.98, and −1.15 eV for DDT, DMDT, FT, FNT, and RM, respectively, on C3N5 monolayers. Significant charge transfers among organic pollutants and C3N5 lead to distinct electronic properties of the conjugated complexes, revealed by the density of states, electrostatic potential, and work function calculations. To detect the selected pollutants in high humidity, the effects due to aqueous medium are considered. Additionally, a statistical thermodynamic analysis utilizing the Langmuir adsorption model is utilized to explore the influence of temperature and pressure.
Fostamatinib for warm antibody autoimmune hemolytic anemia: Phase 3, randomized, double‐blind, placebo‐controlled, global study (FORWARD)
Authors: Kuter David J. , Piatek Caroline , Röth Alexander , Siddiqui Asif , Numerof Robert P. , Dummer Wolfgang ,   the FORWARD study group
Published: November 2023

AbstractWarm antibody autoimmune hemolytic anemia (wAIHA) is characterized by hemolysis and symptomatic anemia with no approved treatment options. Fostamatinib is an oral spleen tyrosine kinase inhibitor approved in the US and Europe for treatment of adults with chronic immune thrombocytopenia. In this phase 3 study, patients with an insufficient response to ≥1 prior wAIHA treatment were randomized to fostamatinib or placebo. The primary endpoint was the proportion of patients to achieve a durable hemoglobin (Hgb) response (Hgb ≥10 g/dL and increase from baseline of ≥2 g/dL on 3 consecutive visits) during the 24‐week treatment period. Ninety patients were randomized, 45 to each arm. Of the fostamatinib‐treated patients, 35.6% achieved a durable Hgb response versus 26.7% on placebo (p = .398). A post hoc analysis revealed a large placebo response in Eastern European patients. Significantly more patients on fostamatinib from North America, Australia and Western Europe exhibited a durable Hgb response compared to placebo (36% vs. 10.7%, p = .030). After censoring for Hgb values impacted by steroid rescue received during screening and excluding 2 placebo patients found to likely not have wAIHA, a reanalysis demonstrated a difference in durable Hgb response between fostamatinib and placebo (15/45 [33.3%] vs. 6/43 [14.0%], p = .0395). At least 1 AE was reported in 42 (93.3%) and 40 (88.9%) patients receiving fostamatinib and placebo, respectively. The most common AEs in the fostamatinib group were diarrhea (26.7%), hypertension (24.4%), and fatigue (15.6%). In this study, fostamatinib demonstrated a clinically meaningful benefit for patients in Western regions, and no new safety signals were identified.
A Photochemical Strategy for ortho‐Aminophenol Synthesis via Dearomative‐Rearomative Coupling Between Aryl Azides and Alcohols
Authors: Li Bo , Ruffoni Alessandro , Leonori Daniele 
Published: November 2023

Abstractortho‐Aminophenols are aromatic derivatives featuring vicinal N‐ and O‐based functionalities commonly found in the structures of many high‐value materials. These molecules are generally prepared using multistep strategies that follow the rules of electrophilic aromatic substitution (SEAr) chemistry. Despite their high fidelity, such approaches cannot target substrates featuring a “contra‐SEAr” arrangement of N‐ and O‐groups. Here we report an alternative strategy for the preparation of such ortho‐aminophenols using aryl azides as the precursors. The process utilizes low‐energy photoexcitation to trigger the decomposition of aryl azides into singlet nitrenes that undergo a dearomative‐rearomative sequence. This allows the incorporation of alcoholic nucleophiles into a seven‐membered ring azepine intermediate via temporary disruption of aromaticity, followed by electrophile‐induced re‐aromatization. The net retrosynthetic logic is that the alcohol displaces the azide, which, in turn, moves to its ortho position and furthermore is converted into an amide. The synthetic value and complementarity of this strategy has been demonstrated by the coupling of aryl azides with complex, drug‐like alcohols and phenols as well as amines, thiols and thiophenols, which provides a general platform for the fast and selective heterofunctionalization of aromatics.
Enhanced flame‐retardant performance of rigid polyurethane foam by using APTES‐MMT and ATH mixed intumescent coatings
Authors: Zhang Wei , Tong Mingyu , Xing Fengqin , Zheng Hui , Zhu Chaonan 
Published: November 2023

AbstractThe design of environment‐friendly fireproof rigid polyurethane foams (RPUFs) that completely prevent ignition or the spread of fires is important for energy conservation and emission reductions. In this paper, an intumescent flame‐retardant coating was prepared and coated onto the surface of a RPUF to improve its flame retardancy. Vertical combustion experiments (UL‐94) showed that, compared with the pure RPUF, a RPUF coated with the expansion coating successfully self‐extinguished without a droplet formed after ignitor removal. Thermogravimetric analyses showed that the expanded coating effectively increased the rate of carbon residue formation. Cone calorimetry showed that when the pigment‐to‐binder ratio was 3.5:1, with 5% modified montmorillonite, 6% aluminum hydroxide, and 4% titanium dioxide, the intumescent coating effectively reduced the heat release rate and total heat release of the RPUF. Remarkably, the smoke release rate and total exhaust gas volume showed that the expanded coating provided obviously enhanced smoke suppression. Therefore, the flame retardancy and toxic smoke suppression provided by the RPUF thermal insulation material is essential and very useful for healthy development of human society and the environment.
Evaluation of the polymer hydrogels as a potential relative permeability modifier
Authors: Rodrigues Taissa Zangerolami Lopes , Flor Júlia Cardoso Dacosta , Palermo Luiz C. M. , Mansur Claudia R. E. 
Published: November 2023

AbstractExcessive water production poses a significant challenge in the oil industry, especially in Pre‐salt carbonate reservoirs, leading to reduced oil recovery, corrosion, and well abandonment. We explore the potential of polymeric preformed particle gels (PPGs) as innovative relative permeability modifiers (RPMs) for carbonate reservoirs. RPMs involve applying polymeric hydrogels to alter reservoir wettability, reducing water flow while enhancing oil productivity. PPGs offer a promising surface‐based production alternative with improved control and minimized formation damage compared to traditional in‐situ gels. We conducted crosslinking experiments using poly(acrylamide‐acrylic acid‐2‐methyl propane sulfonate) terpolymer (AM‐AA‐AMPS) and aluminum (III) ions, assessing their impact on hydrogel properties. We also investigated the swelling behavior of these hydrogels and their interactions with rock samples. Results showed that crosslinking significantly affects PPG viscoelastic properties and swelling behavior. Adsorption tests revealed the formation of a polymeric film on rock surfaces, potentially altering wettability. Contact angle measurements demonstrated PPGs' ability to shift rock wettability, particularly in carbonate samples, from strongly oil‐wet to water‐wet conditions. This study underscores PPGs' potential as RPMs, offering valuable insights into improving oil extraction efficiency and addressing water production challenges in the industry.
Insights on reproduction‐related genes in the striped fruit fly, Zeugodacus scutellata (Hendel) (Diptera: Tephritidae)
Authors: Gokulanathan Anandapadmanaban , Mo Hyoung‐ho , Park Youngjin 
Published: November 2023

AbstractThe striped fruit fly, Zeugodacus scutellata is a significant pest in East and Southeast Asia by damaging Cucurbitaceae blossoms and fruits. To control this pest, a novel strategy to suppress the gene(s) associated with sexually dimorphic phenotypes has been devised and implemented in a laboratory scale. However, comprehensive transcriptomic analysis related to this sex differentiation of Z. scutellata was necessary to determine effective target genes for the genetic control. We performed de novo assembly of the transcript obtained by paired‐end sequencing using an Illumina HiSeq platform and let to 217,967 unigenes (i.e., unique genes) with a minimum length of 200 bp. The female produced 31, 604, 442 reads with 97.93% of Q20, 94.76% of Q30, and the male produced 130, 592, 828 reads with 97.93% of Q20 and 94.76 of Q30%. The differentially expressed genes were used to predict genetic factors associated with sex differentiation, which included Rho1, extra‐macrochaetae (emc), hopscotch (hop), doublesex (dsx), sex‐lethal (sxl), transformer‐2 (tra‐2), testis‐specific serine/threonine‐protein kinase (tssk1), tektin1 (tkt1) and 2 (tkt2), odorant binding proteins (OBPs), fruitless (fru), vitellogenin receptor, and hormone receptors in Z. scutellata. In addition, this transcriptome analysis provides the additional gene associated with sex determination and mating behaviors, which would be applied to develop a novel sterile insect technique against Z. scutellata.
pH‐Sensitive Glucose‐Powered Nanomotors for Enhanced Intracellular Drug Delivery and Ferroptosis Efficiency
Authors: Ji Yuxing , Pan Yanan , Ma Xuemei , Ma Yan , Zhao Zhongxiang , He Qiang 
Published: November 2023

AbstractWe propose a glucose‐powered Janus nanomotor where two faces are functionalized with glucose oxidase (GOx) and polydopamine‐Fe3+ chelates (PDF), respectively. In the glucose fuel solution, the GOx on the one side of these Janus nanomotors catalytically decomposes glucose fuels into gluconic acid and hydrogen peroxide (H2O2) to drive them at a speed of 2.67 μm/s. The underlying propulsion mechanism is the glucose‐based self‐diffusiophoresis owing to the generated local glucose concentration gradient by the enzymatic reaction. Based on the enhanced diffusion motion, such nanomotors with catalytic activity increase the uptake towards cells and subsequently exhibit excellent capabilities for Fe3+ ions delivery and H2O2 generation for enhancing ferroptosis efficiency for inducing cancer cell death. In particular, the Fe3+ ions are released from nanomotors in a slightly acidic environment, and subsequently generate toxic hydroxyl radicals via Fenton reactions, which accumulation reactive oxygen species (ROS) level (~300 %) and further lipid peroxidation (LPO) strengthened ferroptosis therapy for cancer treatment. The as‐developed glucose‐powered Janus nanomotor with efficient diffusion and Fe ions delivery capabilities show great promise as a potential in biomedical applications.
The eukaryotic translation initiation factor eIF4E unexpectedly acts in splicing thereby coupling mRNA processing with translation
Authors: Borden Katherine L. B. 
Published: November 2023

AbstractRecent findings position the eukaryotic translation initiation factor eIF4E as a novel modulator of mRNA splicing, a process that impacts the form and function of resultant proteins. eIF4E physically interacts with the spliceosome and with some intron‐containing transcripts implying a direct role in some splicing events. Moreover, eIF4E drives the production of key components of the splicing machinery underpinning larger scale impacts on splicing. These drive eIF4E‐dependent reprogramming of the splicing signature. This work completes a series of studies demonstrating eIF4E acts in all the major mRNA maturation steps whereby eIF4E drives production of the RNA processing machinery and escorts some transcripts through various maturation steps. In this way, eIF4E couples the mRNA processing‐export‐translation axis linking nuclear mRNA processing to cytoplasmic translation. eIF4E elevation is linked to worse outcomes in acute myeloid leukemia patients where these activities are dysregulated. Understanding these effects provides new insight into post‐transcriptional control and eIF4E‐driven cancers.
High throughput screening for rapid and reliable prediction of monovalent antibody binding behavior in flowthrough mode
Authors: Lorek Julius Klemens , Karkov Hanne Sophie , Matthiesen Finn , Dainiak Maria 
Published: November 2023

AbstractFlowthrough (FT) anion exchange (AEX) chromatography is a widely used polishing step for the purification of monoclonal antibody (mAb) formats. To accelerate downstream process development, high throughput screening (HTS) tools have proven useful. In this study, the binding behavior of six monovalent mAbs (mvAbs) was investigated by HTS in batch binding mode on different AEX and mixed‐mode resins at process‐relevant pH and NaCl concentrations. The HTS entailed the evaluation of mvAb partition coefficients (Kp) and visualization of results in surface‐response models. Interestingly, the HTS data grouped the mvAbs into either a strong‐binding group or a weak‐binding/FT group independent of theoretical Isoelectric point. Mapping the charged and hydrophobic patches by in silico protein surface property analyses revealed that the distribution of patches play a major role in predicting FT behavior. Importantly, the conditions identified by HTS were successfully verified by 1 mL on‐column experiments. Finally, employing the optimal FT conditions (7–9 mS/cm and pH 7.0) at a mini‐pilot scale (CV = 259 mL) resulted in 99% yield and a 21–23‐fold reduction of host cell protein to <100 ppm, depending on the varying host cell protein (HCP) levels in the load. This work opens the possibility of using HTS in FT mode to accelerate downstream process development for mvAb candidates in early research.
The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) dataset
Authors: Ren Liang , Xu Tianhong , Ren Yuhong , Liu Peng 
Published: November 2023

AbstractBackgroundObesity is a risk factor for multiple myeloma (MM). However, we still lack knowledge on the clinical course of obese MM patients in a broad view.MethodsHere, we reviewed 568 MM patients recorded in the Multiple Myeloma Research Foundation (MMRF) coMMpass dataset. Patients were divided into the normal and obese groups according body mass index (BMI) at diagnosis, and then the baseline characteristics, cytogenetic abnormalities, treatment variability, and survival outcomes were evaluated in the obese cohort.ResultsWe found no differences in the characteristics when comparing normal and obese MM patients other than more male in the obese part (50.4% vs. 59.9%, p = 0.024). Compared with the normal BMI patients, median overall survival (OS) was shorter for obese MM patients but without significant meaning (82.3 vs. 95.3 months, p = 0.25). However, in the subgroup analysis, obese MM patients younger than 65 years had significantly inferior OS than that in the normal category (p = 0.047). We also found obese MM patients had a higher overall response rate (ORR) compared with normal BMI patients (92.7% vs. 88.6%, p = 0.037). Additionally, obese patients seemed to achieve faster best response during first‐line therapy.ConclusionsObesity assumes a paradoxical function in the clinical trajectory of myeloma.