bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of incorporation of star‐shaped polycaprolactone on structure‐properties relationship of chitosan‐based networks via urethane/urea linkage
Authors: Amonkol Pennapa , Choochottiros Chantiga 
Published: January 2024

AbstractA chitosan‐based network was fabricated using hexamethylene diisocyanate as a crosslinking agent. The effect was investigated of incorporating star‐shaped polycaprolactone (stPCL) into chitosan‐based networks (CS/stPCL), where the stPCL content varied from 10 to 50 wt%. Quantitative analyses of the urethane/urea linkages and of the stPCL content in the networks were determined based on curve fitting and Soxhlet extraction, respectively. The optimum weight ratio was 80:20 for CS and stPCL (80CS20stPCL), with the highest urethane/urea linkages and stPCL content in the network (30.73%). The compressive testing and rheological analysis indicated that incorporating stPCL enhanced the compressive strength and rheological properties of the chitosan‐based network. In addition, the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide assay of the CS/stPCL network had a cell viability percentage greater than 70%. The CS/stPCL network promoted the formation of an apatite layer on the surface, indicating that the CS/stPCL network could be a promising candidate for tissue engineering.
The room temperature highly sensitive ammonia gas sensor based on polyaniline and nitrogen doped graphene quantum dot coated flower‐like tungsten oxide composite
Authors: Huang Qing‐Yi , Liu Hui‐Ling , Hsu Wei‐Lun , Wu Tzong‐Ming 
Published: January 2024

AbstractIn this study, the newly synthesized polyaniline (PANI)/polyethylenimine modified nitrogen doped graphene quantum dot (PN‐GQD)/tungsten oxide (WO3) ternary composites were used as ammonia (NH3) gas sensor detected the NH3 at room temperature. Fourier transform infrared spectrometer, field‐emission scanning electron microscopy, transmission electron microscopy, and x‐ray photoelectron spectroscopy were applied to illustrate the chemical structure and morphology of the fabricated ternary composites. The NH3 gas‐sensing performances of PANI/PN‐GQD/WO3 composite sensor were determined in the concentration between 0.6 and 2.0 ppm at room temperature and the response value of the ternary composite sensor with an exposure of 1.0 ppm NH3 was 19.9, which was much better than those of PANI and PANI/WO3 sensors. Because their highly sensitive detection of NH3 ranging from the concentration between 0.6 and 2.0 ppm at room temperature, the PANI/PN‐GQD/WO3 composite sensor was confirmed to be extremely effective to detect the kidney or hepatic disease from the human breath. This ternary composite sensor with an exposure of 1.0 and 2.0 ppm NH3 also displayed extraordinary repeatability and selectivity at room temperature. According to these findings, this fabricated PANI/PN‐GQD/WO3 composite sensor will be an excellent gas‐sensing material to detect the kidney or hepatic disease from the human breath.
Low latitude mesospheric clouds in a warmer climate
Authors: Dutta Deepashree , Sherwood Steven C. , Meissner Katrin J. , Jucker Martin 
Published: January 2024

AbstractObservations show that mesospheric clouds (MCs) have been increasing in recent decades, presumably due to increased mesospheric water vapor which is mainly caused by greater methane (CH4) oxidation in the middle atmosphere. Past warm climates such as those of the early Cretaceous and Paleogene periods are thought to have had higher CH4 concentrations than present day, and future CH4 concentrations will also likely continue to rise. Here, idealized atmosphere chemistry‐climate model experiments forced with strong polar‐amplified sea‐surface temperatures and elevated carbon dioxide (CO2) and CH4 concentrations predict a substantial spreading of MCs to middle and low latitudes, well beyond regions where they are currently found. Sensitivity tests show that increased water vapor from CH4 oxidation and cooling from increased CO2 and CH4 concentrations create favorable conditions for cloud formation, producing MC fractions of 0.02 in the low latitudes and 0.1 in the mid‐latitudes in the Northern Hemisphere when CH4 concentration is 16× higher than pre‐industrial. Further increases in CH4 result in a monotonic increase in low‐ and mid‐latitude MCs. A uniform surface ocean warming, changes in polar amplification, or the solar constant do not significantly affect our results. While the appearance of these clouds is interesting, their ice and liquid water content is not sufficient to cause a significant radiative effect. On the other hand, dehydration of the mesosphere due to these low‐ and mid‐latitude MCs could potentially lead to a reduction in atomic hydrogen, thereby affecting mesospheric ozone concentration, although further study is required to confirm this.
Einfluss der Querschnittshöhe auf die Biegezugfestigkeit von ultrahochfestem Beton
Authors: Schuller Jan , Leutbecher Torsten 
Published: January 2024

AbstractNeben der zentrischen Zugfestigkeit definiert Eurocode 2 (EC2) eine sogenannte Biegezugfestigkeit. Die Biegezugfestigkeit hängt von der Betonzugfestigkeit, der Querschnittshöhe des Biegebauteils und von der Sprödigkeit des Betons ab. Bei der Ermittlung von Spannungen und Biegeverformungen im Gebrauchszustand darf nach EC2 von ungerissenen Querschnitten ausgegangen werden, wenn die Biegezugspannung die Biegezugfestigkeit nicht überschreitet. Für ultrahochfesten Beton (UHFB) fehlt bislang ein rechnerischer Ansatz zur Bestimmung der Biegezugfestigkeit. Daher werden in dieser Arbeit die Biegezugfestigkeit, die zentrische Zugfestigkeit, die Spaltzugfestigkeit und die Druckfestigkeit an faserfreiem Feinkorn‐ und Grobkorn‐UHFB bestimmt und zusammen mit Daten anderer Studien untereinander in Beziehung gesetzt. Es zeigt sich, dass Grobkorn‐UHFB bei vergleichbarer Druckfestigkeit tendenziell niedrigere Zug‐, Biegezug‐ und Spaltzugfestigkeiten als Feinkorn‐UHFB aufweist. Durch Wasserlagerung der Probekörper kann Eigenspannungen vorgebeugt werden, die bei Wärmebehandlung oder Trockenlagerung die messbare Zugfestigkeit mit zunehmender Querschnittsgröße stärker mindern. Zur rechnerischen Bestimmung der Biegezugfestigkeit von UHFB wird ein Ansatz vorgeschlagen, der eine lineare Abhängigkeit von der Querschnittshöhe vorsieht. Der Ansatz kann für Feinkorn‐ und Grobkorn‐UHFB angewendet werden. Die Ergebnisse der Arbeit sollen Eingang in die DAfStb‐Richtlinie „Ultrahochfester Beton“ finden.
Hypoxia‐responsive AIEgens for precise disease theranostics
Authors: Liu Dongfang , Liang Mengyun , Fan Aohua , Bing Wei , Qi Ji 
Published: January 2024

AbstractSpecific biomarker‐activatable probes have revolutionized theranostics, being beneficial for precision medicine. Hypoxia is a critical pathological characteristic prevalent in numerous major diseases such as cancers, cardiovascular disorders, inflammatory diseases, and acute ischemia. Aggregation‐induced emission luminogens (AIEgens) have emerged as a promising tool to tackle the biomedical issues. Of particular significance are the hypoxia‐responsive AIEgens, representing a kind of crucial probe capable of delicately sensing and responding to the hypoxic microenvironment, thereby enhancing the precision of disease diagnosis and treatment. In this review, we summarize the recent advances of hypoxia‐responsive AIEgens for varied biomedical applications. The hypoxia‐responsive structures based on AIEgens, such as azobenzene, nitrobenzene, and N‐oxide are presented, which are in response to the reduction property to bring about significant alternations in response spectra and/or fluorescence intensity. The bioapplications including imaging and therapy of tumor and ischemia diseases are discussed. Moreover, the review sheds light on the future challenges and prospects in this field. This review aims to provide comprehensive guidance and understanding into the development of activatable bioprobes, especially the hypoxia‐responsive AIEgens for improving the diagnosis and therapy outcome of related diseases.
A comprehensive framework for the sustainability indicators in the textile industry of developing countries
Authors: Fadara Taiwo Gbolarumi , Wong Kuan Yew , Zarei Hossein 
Published: January 2024

AbstractTextile production in developing countries is known to be associated with significant environmental, social, and economic challenges. Existing research has mostly focused on singular aspects of sustainability, while no consensus exists on the importance and applicability of sustainability indicators. To address these gaps, this study utilized an integrated approach involving the Delphi method and the fuzzy best‐worst method (BWM) to develop a comprehensive framework by identifying and formulating sustainability indicators tailored for the textile industry in developing countries and assess their importance and applicability. Through three consecutive rounds of Delphi, a total of 64 sustainability indicators were identified (16 economic, 24 environmental, and 24 social indicators). Next, fuzzy BWM was employed to determine the importance and applicability of these indicators. The results show that (a) environmental indicators overall have higher applicability scores, (b) the top three critical indicators were raw material usage, operational costs, and fuel consumption, and (c) nearly half of the indicators (29/64) were deemed highly applicable, with 34.5% (10/29) of these falling under environmental, 34.5% (10/29) under economic, and 31% (9/29) under social dimensions. Finally, the utility of the framework is demonstrated through an empirical case study in a textile manufacturing company in Nigeria.
Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population‐based analysis
Authors: He Lin‐feng , Zhang Jin‐di , Zhu Teng‐fei , Zhao Peng‐cheng , Mou Pei , Tang Shi‐yi 
Published: January 2024

AbstractBackgroundStudies on the epidemiological information and prognosis of primary malignant lacrimal gland tumors (MLGTs) are rare for its low occurrence. The goal of our research was to investigate the epidemiological characteristics and survival outcomes of patients with MLGTs.MethodsIncidence and demographic information of patients with MLGTs were collected from the Surveillance, Epidemiology, and End Results (SEER) database. To identify independent prognostic factors for disease‐specific survival (DSS) and overall survival (OS), univariate and multivariate Cox regression analysis were performed.ResultsThe overall incidence of primary MLGTs from 1975 to 2020 was 0.413/1,000,000 (according to the 2000 American standard population), with a steadily increasing incidence over years. A total of 964 patients with primary MLGTs were diagnosed, with an average age of 59.3 years. Of these, 53.2% were aged ≥60 years, 57.4% were female, and 77.1% were whites. Multivariate Cox regression analysis demonstrated that year of diagnosis, age, sex, histological type, SEER stage, surgery, and chemotherapy were independent prognostic factors of DSS or OS.ConclusionsAlthough primary MLGT is rare, its incidence has steadily increased in the past 46 years, and surgery was related to a better prognosis.
A metagenomic survey of bacterial communities from kurut: The fermented cow milk in Kyrgyzstan
Authors: Yegin Zeynep , Mamatova Zhanylbubu , Yurt Mediha Nur Zafer , Tasbasi Behiye Busra , Acar Elif Esma , Ucak Samet , Süleymanoğlu Ali Anıl , Aydin Ali , Ozalp Veli Cengiz , Sudagidan Mert 
Published: January 2024

AbstractKurut is a traditional dry dairy product mostly consumed in Central Asia. In this study, the distribution of the dominant bacteria present in kurut samples (n=84) originated from seven (Chuy, Issyk‐Kul, Talas, Naryn, Jalal‐Abad, Osh, and Batken) regions in Kyrgyzstan were analyzed with Illumina iSeq100 platform. The dominant phylum detected was Firmicutes followed by Proteobacteria, Actinobacteria, Cyanobacteria/Chloroplast, and Tenericutes. The most abundant family detected was Lactobacillaceae followed by Streptococcaceae, Enterococcaceae, Chloroplast, and Leuconostocaceae. At the genus level, Lactobacillus was the predominant one in samples and Streptococcus, Enterococcus, Lactococcus, and Streptophyta followed this. Further comprehensive characterization analyses in kurut samples may have potential applications both in industrial starter culture developments and also future therapeutic approaches based on potential strains with probiotic properties.
Heterochiral modifications enhance robustness and function of DNA in living human cells
Authors: Mallette Tracy L. , Lidke Diane S. , Lakin Matthew R. 
Published: January 2024

AbstractOligonucleotide therapeutics are becoming increasingly important as more are approved by the FDA, both for treatment and vaccination. Similarly, dynamic DNA nanotechnology is a promising technique that can be used to sense exogenous input molecules or endogenous biomarkers and integrate the results of multiple sensing reactions in situ via a programmed cascade of reactions. The combination of these two technologies could be highly impactful in biomedicine by enabling smart oligonucleotide therapeutics that can autonomously sense and respond to a disease state. A particular challenge, however, is the limited lifetime of standard nucleic acid components in living cells and organisms due to degradation by endogenous nucleases. In this work, we address this challenge by incorporating mirror‐image, ʟ‐DNA nucleotides to produce heterochiral “gapmers”. We use dynamic DNA nanotechnology to show that these modifications keep the oligonucleotide intact in living human cells for longer than an unmodified strand. To this end, we used a sequential transfection protocol for delivering multiple nucleic acids into living human cells while providing enhanced confidence that subsequent interactions are actually occurring within the cells. Taken together, this work advances the state of the art of ʟ‐nucleic acid protection of oligonucleotides and DNA circuitry for applications in vivo.
Genomic heterogeneity at baseline is associated with T790M resistance mutations in EGFR‐mutated lung cancer treated with the first‐/second‐generation tyrosine kinase inhibitors
Authors: Menzel Michael , Kirchner Martina , Kluck Klaus , Ball Markus , Beck Susanne , Allgäuer Michael , Assmann Christin , Schnorbach Johannes , Volckmar Anna‐Lena , Tay Timothy Kwang Yong , Goldschmid Hannah , Tan Daniel SW , Thomas Michael , Kazdal Daniel , Budczies Jan , Stenzinger Albrecht , Christopoulos Petros 
Published: January 2024

AbstractThis study analyzed whether extended molecular profiling can predict the development of epidermal growth factor receptor (EGFR) gene T790M mutation, which is the most frequent resistance alteration in non‐small cell lung cancer (NSCLC) after treatment with the first‐/second‐generation (1G/2G) EGFR inhibitors (tyrosine kinase inhibitors [TKIs]), but only weakly associated with clinical characteristics. Whole exome sequencing (WES) was performed on pretreatment tumor tissue with matched normal samples from NSCLC patients with (n = 25, detected in tissue or blood rebiopsies) or without (n = 14, negative tissue rebiopsies only) subsequent EGFR p.T790M mutation after treatment with 1G/2G EGFR TKI. Several complex genetic biomarkers were assessed using bioinformatic methods. After treatment with first‐line afatinib (44%) or erlotinib/gefitinib (56%), median progression‐free survival and overall survival were 12.1 and 33.7 months, respectively. Clinical and tumor genetic characteristics, including age (median, 66 years), sex (74% female), smoking (69% never/light smokers), EGFR mutation type (72% exon 19 deletions), and TP53 mutations (41%) were not significantly associated with T790M mutation (p > 0.05). By contrast, complex biomarkers including tumor mutational burden, the clock‐like mutation signature SBS1 + 5, tumor ploidy, and markers of subclonality including mutant‐allele tumor heterogeneity, subclonal copy number changes, and median tumor‐adjusted variant allele frequency were significantly higher at baseline in tumors with subsequent T790M mutation (all p < 0.05). Each marker alone could predict subsequent development of T790M with an area under the curve (AUC) of 0.72–0.77, but the small number of cases did not allow confirmation of better performance for biomarker combinations in leave‐one‐out cross‐validated logistic regression (AUC 0.69, 95% confidence interval: 0.50–0.87). Extended molecular profiling with WES at initial diagnosis reveals several complex biomarkers associated with subsequent development of T790M resistance mutation in NSCLC patients receiving first‐/second‐generation TKIs as the first‐line therapy. Larger prospective studies will be necessary to define a forecasting model.
Factors affecting the nesting success of Swainson's Thrush (Catharus ustulatus) along an elevational gradient
Authors: Deckel Sarah C. , DeLuca William V. , Gerson Alexander R. , King David I. 
Published: January 2024

AbstractMontane birds experience a range of challenges that may limit their breeding success, including nest predation and severe climactic conditions. The continuing effects of climate change are causing shifts in biotic and abiotic factors that may compound these threats to montane bird species. In northeastern montane forests, many bird species are shifting downslope, potentially as the result of increased precipitation and temperature at higher elevations. Although lower elevations might be more favorable in terms of climactic conditions, nest predation is higher at lower elevations. Thus, montane birds might be faced with the opposing pressures of adverse climactic conditions at higher elevations and increased predation at lower elevations. We monitored nests of Swainson's Thrush (Catharus ustulatus) along an elevation gradient in the White Mountain National Forest in New Hampshire in 2016, 2018, 2019, and 2021 to examine the effect of biotic and abiotic factors on daily nest survival rate (DSR). Linear time explained the most variation of DSR in AICc model comparison, indicating that DSR decreases across the breeding season. Rain intensity (mm/h) had a weak negative effect on DSR, indicating that heavier rain per hour decreases Swainson's Thrush DSR. Moreover, we found some support for a negative interaction effect of elevation in conjunction with minimum daily temperature: DSR of Swainson's Thrush nests at low elevations (281 m) increased with increasing minimum daily temperatures and decreased at high elevations with increasing minimum daily temperatures. Our results suggest nesting survival of montane breeding birds may be at risk as heavier precipitation events become more frequent and intense due to the changing climate and raises the possibility that other passerine species could be at risk in this system.
Photographic documentation of melanism in bobcats (Lynx rufus) in the Greater Everglades
Authors: Branney Aidan B. , Abernathy Heather N. , Conner L. Mike , Garrison Elina , Cherry Michael J. 
Published: January 2024

AbstractWe document the presence of bobcats (Lynx rufus) that demonstrate melanism in the Greater Everglades. The South Florida landscape is driven by a myriad of disturbance regimes particularly that of short fire intervals. We monitored 180 camera traps for 3 years and obtained 9503 photographs of bobcats 25 (<0.5%) of these detections included melanistic individuals. Our observations and historical accounts suggest melanism is a phenotype that persists, albeit it at an exceedingly low frequency, in bobcats in the region. While we do not know if the expression of melanism conferred a fitness benefit in our system, the vegetation structure that was characterized by frequently burned uplands and low‐light and densely vegetated swamps produced conditions that may render a benefit from melanism through enhanced crypsis. The investigation of rare phenomenon in ecology is important yet difficult within a given field study, but reporting novel observations, like melanism in bobcats, allows for science to gain insight across studies that would not be otherwise possible.
Parent–child correlation in energy and macronutrient intakes: A meta‐analysis and systematic review
Authors: Teymoori Farshad , Norouzzadeh Mostafa , Farhadnejad Hossein , Jahromi Mitra Kazemi , Ahmadirad Hamid , Saber Niloufar , Akbarzadeh Mahdi , Zarkesh Maryam , Daneshpour Maryam S. , Mirmiran Parvin , Vafa Mohammadreza 
Published: January 2024

AbstractIn the current study, we aimed to review the evidence from twin and family‐based studies that have assessed the familial similarity in intakes of energy and macronutrients among various parent–child pairs. The online literature databases, including Web of Science, PubMed, and Scopus, were searched up to December 2022 to find potentially eligible studies. We converted Pearson's, Spearman's, or intra‐class correlation coefficients to z's using Fisher's z transformation to obtain approximate normality and then calculated a mean and standard error (SE) of transformed correlation weighted by the sample sizes in the studies. We reported pooled r and 95% CI as our final results in five groups, including parent–child, mother–daughter, mother–son, father–daughter, and father–son. Twenty‐one eligible studies were included in this meta‐analysis, in which the sample size ranged from 33 and 4310. Our analysis showed that family resemblance in the intake of energy and macronutrients in various parent–offspring pairs was weak to moderate which could be different based on family pairs, nutrients, and studies. The highest similarity in dietary intakes was observed among the mother–daughter pair, which was for carbohydrate and protein intake, respectively. The lowest correlations in dietary intakes were found between mother–son or father–son pairs. Our meta‐analysis suggested that family similarity for intakes of energy and macronutrients was not strong in parent–child pairs. The highest correlation in dietary intake was mostly found in mother–daughter pairs. The weak similarities in dietary intake among parent–child pairs indicate the noticeable effect of the environment outside the family on individuals' dietary choices.