bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional labour and turnover intention among nurses in China: Mediating effects of nurse–patient relationship and self‐rated health
Authors: Liu Zhixin , Zhang Huanyu , Liu Junping , Zhao Juan , Feng Yajie , Liu Jie , Tao Siyi , Liu Wei , Zou Dandan , Wang Chen , Wang Nan , Liu Zhaoyue , Liu Xinru , Wu Lin , Liang Libo , Xu Weilan , Wu Qunhong , Liu Chaojie 
Published: January 2024

AbstractAimThis study tested the mediating role of the nurse–patient relationship and self‐rated health in the effect of emotional labour on turnover intention among nurses in China.BackgroundThe underlying mechanism behind the effect of emotional labour on turnover intention remains inadequately understood.IntroductionNurses with a high level of emotional labour are predisposed to experiencing poor health and tension in their relationships with patients, which may increase turnover intention.MethodsA cross‐sectional survey of 527 nurses in a public tertiary hospital in Qiqihar, located in China's Heilongjiang province, was conducted. Emotional labour and turnover intention were assessed using existing validated scales containing multiple items, while the nurse–patient relationship and self‐rated health were assessed using single items, respectively. Baron and Kenny's causal steps and the Karlson/Holm/Breen method were adopted to test the mediating effects of the nurse–patient relationship and self‐rated health in the association between emotional labour and turnover intention after adjusting for variations in sociodemographic and job characteristics.ResultsEmotional labour was positively associated with turnover intention. Self‐rated poor health and a disharmonious nurse–patient relationship partially mediated the positive effect of emotional labour on turnover intention.ConclusionsEmotional labour significantly affects the turnover intention of nurses working in public tertiary hospitals in China, and this effect is partially mediated by self‐rated health and the nurse–patient relationship.Implications for nursing practice and nursing policyGiving more attention to nurses’ negative emotions and work attitudes is crucial. Developing comprehensive strategies for enhancing nurses’ emotional management ability, promoting their physical and psychological well‐being, and improving nurse–patient relationship to reduce nurses’ turnover.
Psychotherapeutic nursing as Advanced Clinical Practice for the promotion of mental health in Spain
Authors: García‐Sastre María Montserrat , Castro‐Molina Francisco Javier , Cabanillas Rubén Chacón , Corrales Carmen Sánchez , Jardón Golmar Laura , Carretero Román Julián , Aguilera Serrano Carlos ,   Spanish Association of Mental Health Nursing
Published: January 2024

AbstractObjectiveTo contribute to the recognition of psychotherapeutic nursing (PTN) as a regulated advanced clinical practice (ACP) in Spain, as is the case in other countries.BackgroundNurses are continually evolving to improve overall health outcomes. PTN has become a reality, with several authors describing it as an ACP. In Spain, psychotherapy is not officially regulated, which has led to a significant number of psychiatric nurses adopting an important ACP in this area without recognition.Sources of evidenceEvidence confirms that PTN possesses the attributes necessary to be considered an ACP. Nurses, like psychotherapists, independently address the complex needs of individuals and families within the context of therapeutic relationships, and there is a pressing need to advance formal processes of regulation and certification.DiscussionPTN has evolved at different rates depending on local initiatives, policies and various professional interests. In Spain, it is crucial to evaluate its outcomes, recognise it as an ACP and develop training plans for its regulation and accreditation.ConclusionsMental health nurses in Spain have a strong interest in PTN being recognised as an ACP. To this end, they should join forces with other partners, scientific associations and international bodies such as the International Council of Nurses (ICN) to make PTN an internationally recognised ACP.Implications for nursing practicePsychotherapeutic nurses could contribute to improving mental health outcomes, client satisfaction and health system efficiency, and their formal recognition is an opportunity to enhance their professional identity, competence and autonomy.Implications for nursing policyNursing policy needs to be reoriented towards strengthening psychotherapy as an ACP. Synergies and alliances between international nursing associations and the ICN can promote its development and implementation, while research, education and leadership are essential to achieving official regulation and accreditation.
Assessing the mediation pathways: How decent work affects turnover intention through job satisfaction and burnout in nursing
Authors: Xue Bowen , Feng Yaping , Hu Zhiguo , Chen Yaqian , Zhao Yihui , Li Xin , Yang Yang , Zhang Jingxuan , Zhang Yu , Luo Hong 
Published: January 2024

AbstractAimThis study aimed to assess the potential mediating roles of nurses' job satisfaction and burnout in the association between decent work and turnover intention.BackgroundThere is a global challenge of nursing shortages in healthcare systems worldwide. Decent work is crucial for safeguarding the rights and professional development outcomes of nurses. However, there is currently limited research on decent work among nurses, and there is a lack of studies exploring the relationships between nurses' decent work, job satisfaction, burnout, and turnover intention.MethodsA cross‐sectional survey design was employed with a sample of 460 nurses from three hospitals: The Affiliated Hospital of Hangzhou Normal University, Hangzhou Third People's Hospital, and Hangzhou Red Cross Hospital. The STROBE checklist was used. Mediation analysis using the PROCESS Macro was used to examine the relationships between decent work, job satisfaction, burnout, and turnover intention.ResultsThe results showed that nurses' perception of decent work directly influences their turnover intention. Additionally, these findings strongly support the role of job satisfaction and burnout as mediating factors in the relationship between decent work and turnover intention.ConclusionsDecent work reduces nurse burnout and turnover intention of enhancing their job satisfaction.Implications for nursing and health policyThis study's findings have important implications for healthcare organizations and policymakers. Recognizing the pivotal role of decent work in nurses' job satisfaction and well‐being can guide the development of strategies to improve working conditions and reduce turnover rates. It is imperative for healthcare institutions to prioritize creating safe, supportive, and equitable work conditions for nurses, as this can contribute to higher job satisfaction and, subsequently, lower turnover rates.
High‐temperature phase transformation and thermodynamic properties of Ca3(VO4)2
Authors: Pei Guishang , Jiao Mengjiao , Li Zhuoyang , Li Yongda , Zhang Ningyu , Xin Yuntao , Lv Xuewei 
Published: January 2024

AbstractCa3(VO4)2 is a promising candidate for applications in ferroelectric, laser host, and optical materials owing to its unique whitlockite structure and excellent physicochemical properties. In this study, the Ca3(VO4)2 powder was fabricated via a conventional solid‐phase route in air, using V2O5 and CaO as precursors. The trigonal Ca3(VO4)2 belongs to the space group R3c, having unit cell parameters of a = 10.8074 Å, b = 10.8074 Å, and c = 37.98871 Å, respectively. Ca3(VO4)2 melts congruently at 1680 K, as determined from differential scanning calorimetry measurements of the thermal profile of the second heating test. Enthalpy changes in Ca3(VO4)2 were experimentally determined for the first time across temperatures between 573 and 1623 K by drop calorimetry. The temperature‐dependent molar heat capacity of Ca3(VO4)2 was calculated from the enthalpy changes at elevated temperatures. Thermodynamic properties (entropy, enthalpy, and Gibbs free energy changes) were also calculated. The thermodynamic properties measured in this study were further applied to evaluate the appropriate precursors for fabricating Ca3(VO4)2 via solid‐state calcination. The results strongly recommend the use of V2O5 and Ca(OH)2 precursors for preparing the Ca3(VO4)2 samples because of their thermodynamic advantages.
Machine learning and phylogenetic models identify predictors of genetic variation in Neotropical amphibians
Authors: Amador Luis , Arroyo‐Torres Irvin , Barrow Lisa N. 
Published: January 2024

AbstractAimIntraspecific genetic variation is key for adaptation and survival in changing environments and is known to be influenced by many factors, including population size, dispersal and life‐history traits. We investigated genetic variation within Neotropical amphibian species to provide insights into how natural history traits, phylogenetic relatedness, climatic and geographic characteristics can explain intraspecific genetic diversity.LocationNeotropics.TaxonAmphibians.MethodsWe assembled data sets using open‐access databases for natural history traits, genetic sequences, phylogenetic trees, climatic and geographic data. For each species, we calculated overall nucleotide diversity (π) and tested for isolation by distance (IBD) and isolation by environment (IBE). We then identified predictors of π, IBD and IBE using random forest (RF) regression or RF classification. We also fitted phylogenetic generalized linear mixed models (PGLMMs) to predict π, IBD and IBE.ResultsWe compiled 4052 mitochondrial DNA sequences from 256 amphibian species (230 frogs and 26 salamanders), georeferencing 2477 sequences from 176 species that were not linked to occurrence data. RF regressions and PGLMMs were congruent in identifying range size and precipitation (σ) as the most important predictors of π, influencing it positively. RF classification and PGLMMs identified minimum elevation as an important predictor of IBD; most species without IBD tended to occur at higher elevations. Maximum latitude and precipitation (σ) were the best predictors of IBE, and most species without IBE occur at lower latitudes and in areas with more variable precipitation.Main ConclusionsThis study identified predictors of genetic variation in Neotropical amphibians using both machine learning and phylogenetic methods. This approach was valuable to determine which predictors were congruent between methods. We found that species with small ranges or living in zones with less variable precipitation tended to have low genetic diversity. We also showed that Western Mesoamerica, Andes and Atlantic Forest biogeographic units harbour high diversity across many species that should be prioritized for protection. These results could play a key role in the development of conservation strategies for Neotropical amphibians.
Long non‐coding RNA as a potential diagnostic and prognostic biomarker in melanoma: A systematic review and meta‐analysis
Authors: Masrour Mahdi , Khanmohammadi Shaghayegh , Fallahtafti Parisa , Hashemi Seyedeh Melika , Rezaei Nima 
Published: January 2024

AbstractRecently, long noncoding RNAs (lncRNAs) have been applied as biomarkers for melanoma patients. In this systematic review and meta‐analysis, we investigated the diagnostic and prognostic value of lncRNAs. We used the keywords ‘lncRNA’ and ‘melanoma’ to search databases for studies published before June 14th, 2023. The specificity, sensitivity and AUC were utilized to assess diagnostic accuracy and the prognostic value was assessed using overall survival, progression‐free survival and disease‐free survival hazard ratios. After screening 1191 articles, we included seven studies in the diagnostic evaluation section and 17 studies in the prognosis evaluation section. The Reitsma bivariate model estimated a cumulative sensitivity of 0.724 (95% CI: 0.659–0.781, p < 0.001) and specificity of 0.812 (95% CI: 0.752–0.859, p < 0.001). The pooled AUC was 0.780 (95% CI: 0.749–0.811, p < 0.0001). The HR for overall survival was 2.723 (95% CI: 2.259–3.283, p < 0.0001). Two studies reported an HR for overall survival less than one, with an HR of 0.348 (95% CI: 0.200–0.607, p < 0.0002). The HR for progression‐free survival was 2.913 (95% CI: 2.050–4.138, p < 0.0001). Four studies reported an HR less than one, with an HR of 0.457 (95% CI: 0.256–0.817). The HR for disease‐free survival was 2.760 (95% CI: 2.009–3.792, p < 0.0001). In conclusion, the expression of lncRNAs in melanoma patients affects survival and prognosis. LncRNAs can also be employed as diagnostic biomarkers.
Associations between diet quality and dietary patterns and gestational diabetes mellitus in a low‐risk cohort of pregnant women in Australia: a cross‐sectional study
Authors: Ebrahimi Sara , Ellery Stacey J. , Leech Rebecca M. , van der Pligt Paige F. 
Published: January 2024

AbstractIntroductionEvidence of associations between the Mediterranean Diet Score (MDS) and Dietary Approaches to Stop Hypertension (DASH) score and gestational diabetes mellitus (GDM) in pregnant women is limited. This study examined changes in MDS and DASH and dietary patterns in Australian pregnant women between early and late pregnancy and their associations with GDM.MethodsThe data from n = 284 participants were analysed. Diet quality indices and empirical dietary patterns were determined in early (15 ± 3 weeks gestation) and late pregnancy (35 ± 2 weeks gestation). Paired t‐tests were used to examine changes in scores for diet quality indices and dietary patterns from early to late pregnancy. Logistic regression analysis was used to examine associations between GDM, diet quality indices and dietary patterns.ResultsThree major dietary patterns were identified at early pregnancy. The first and second dietary patterns included unhealthier and healthier food groups, respectively, and the third comprised mixed food groups. Although diet quality scores did not change over time, consumption of the first dietary pattern increased (p = 0.01), and consumption of the second dietary pattern decreased by late pregnancy in women without GDM (p < 0.001).ConclusionNo associations between DASH score, MDS and GDM were found; however an inverse association was observed between the first dietary pattern and GDM in late pregnancy (p = 0.023). Longitudinal studies are needed to examine diet quality and dietary patterns at early and late pregnancy to inform the development of tailored dietary advice for GDM.
Nicotinamide mononucleotide alleviates seizures via modulating SIRT1‐PGC‐1α mediated mitochondrial fusion and fission
Authors: Cheng Yahong , Huang Puxin , Zou Qixian , Tian Hui , Cheng Qingzhou , Ding Hong 
Published: January 2024

AbstractBoth human and animal experiments have demonstrated that energy metabolism dysfunction in neurons after seizures is associated with an imbalance in mitochondrial fusion/fission dynamics. Effective neuronal mitochondrial dynamics regulation strategies remain elusive. Nicotinamide mononucleotide (NMN) can ameliorate mitochondrial functional and oxidative stress in age‐related diseases. But whether NMN improves mitochondrial energy metabolism to exert anti‐epileptic effects is unclear. This study aims to clarify if NMN can protect neurons from pentylenetetrazole (PTZ) or Mg2+‐free‐induced mitochondrial disorder and apoptosis via animal and cell models. We established a continuous 30‐day PTZ (37 mg/kg) intraperitoneal injection‐induced epileptic mouse model and a cell model induced by Mg2+‐free solution incubation to explore the neuroprotective effects of NMN. We found that NMN treatment significantly reduced the seizure intensity of PTZ‐induced epileptic mice, improved their learning and memory ability, and enhanced their motor activity and exploration desire. At the same time, in vitro and in vivo experiments showed that NMN can inhibit neuronal apoptosis and improve the mitochondrial energy metabolism function of neurons. In addition, NMN down‐regulated the expression of mitochondrial fission proteins (Drp1 and Fis1) and promoted the expression of mitochondrial fusion proteins (Mfn1 and Mfn2) by activating the SIRT1‐PGC‐1α pathway, thereby inhibiting PTZ or Mg2+‐free extracellular solution‐induced mitochondrial dysfunction, cell apoptosis, and oxidative stress. However, combined intervention of SIRT1 inhibitor, Selisistat, and PGC‐1α inhibitor, SR‐18292, eliminated the regulatory effect of NMN pre‐treatment on mitochondrial fusion and fission proteins and apoptosis‐related proteins. Therefore, NMN intervention may be a new potential treatment for cognitive impairment and behavioral disorders induced by epilepsy, and targeting the SIRT1‐PGC‐1α pathway may be a promising therapeutic strategy for seizures.image
Male rat hypothalamic extraretinal photoreceptor Opsin3 is sensitive to osmotic stimuli and light
Authors: Bárez‐López Soledad , Bishop Paul , Searby Daniel , Murphy David , Greenwood Michael P. 
Published: January 2024

AbstractThe light‐sensitive protein Opsin 3 (Opn3) is present throughout the mammalian brain; however, the role of Opn3 in this organ remains unknown. Since Opn3 encoded mRNA is modulated in the supraoptic and paraventricular nucleus of the hypothalamus in response to osmotic stimuli, we have explored by in situ hybridization the expression of Opn3 in these nuclei. We have demonstrated that Opn3 is present in the male rat magnocellular neurones expressing either the arginine vasopressin or oxytocin neuropeptides and that Opn3 increases in both neuronal types in response to osmotic stimuli, suggesting that Opn3 functions in both cell types and that it might be involved in regulating water balance. Using rat hypothalamic organotypic cultures, we have demonstrated that the hypothalamus is sensitive to light and that the observed light sensitivity is mediated, at least in part, by Opn3. The data suggests that hypothalamic Opn3 can mediate a light‐sensitive role to regulate circadian homeostatic processes.
Preparation and in vitro evaluation of protective effects of Silibinin‐loaded polymeric micelles on human hair against UV‐B radiation
Authors: Zadeh Behzad Sharif Makhmal , Akbari Hamed , Salimi Anayatollah 
Published: January 2024

AbstractBackgroundThe purpose of this study was to investigate the protective effect of Silibinin‐loaded polymeric micelles from human hair against UV‐B radiation.MethodsEight formulations with different concentrations of Silibinin, Pluronic F‐127, and Labrasol‐Labrafil were made by a solvent evaporation method, and the selected formulation was chosen by examining their properties like particle size and loading efficiency. Six groups of human hair, including a group that received the selected formulation, were exposed to UV‐B radiation and by calculating its factors such as peak‐to‐valley roughness, RMS roughness, FTIR, and the amount of protein loss, the protective effect of the selected formulation was judged.ResultsAccording to the results, the loading efficiency and particle size of the selected formulation were 45.34% and 43.19 nm. The Silibinin release profile had two parts, fast and slow, which were suitable for creating a drug depot on hair. Its zeta potential also confirmed the minimum electrostatic interference between the formulation and hair surface. The zeta potential of selected formulation was −5.9 mv. Examination of AFM images showed that the selected formulation was able to prevent the increase in peak‐to‐valley roughness and RMS roughness caused by UV‐B radiation. RMS roughness after 600 h of UV radiation in Groups 5 and 6 was significantly lower than the negative control group and the amount of this factor did not differ significantly between 0 and 600, so it can be concluded that the selected formulation containing Silibinin and the positive control group was able to prevent the increase of RMS roughness and hair destruction. In other hands, the two positive control groups and the selected formulation containing Silibinin were able to effectively reduce hair protein loss.ConclusionSilibinin‐loaded polymeric micelles were able to effectively protect hair from structural and chemical changes caused by UV‐B radiation.
The role of brain perfusion SPECT in the diagnosis of frontotemporal dementia: A systematic review
Authors: Athanasio Bruno S. , Oliveira Ana Cecília de Sena , Pedrosa Ana Luísa , Borges Rafael S. , Neto Avelar O. M. , Oliveira Rafael A. , de Resende Elisa de Paula França , de Moraes Renata Freire , Caramelli Paulo , de Souza Leonardo Cruz 
Published: January 2024

AbstractBackground and PurposeFrontotemporal dementia (FTD) is the second most common cause of presenile dementia. The clinical distinction between FTD, Alzheimer's disease (AD), and other dementias is a clinical challenge. Brain perfusion SPECT may contribute to the diagnosis of FTD, but its value is unclear.MethodsWe performed a systematic review to investigate the diagnostic accuracy of the brain SPECT in (1) distinguishing FTD from AD and other dementias and (2) differentiating FTD variants.ResultsOverall, 391 studies were retrieved on the initial search and 35 studies composed the final selection, comprising a total number of 3142 participants of which 1029 had FTD. The sensitivity and the specificity for the differential diagnosis of FTD versus AD ranged from 56% to 88% and from 51% to 93%, respectively. SPECT is not superior to the clinical method of diagnosis, but the combination of SPECT with clinical data seems to improve the diagnostic accuracy.ConclusionBrain perfusion SPECT has a limited value in the diagnostic framework of FTD. SPECT can be performed when FDG‐PET is not available. SPECT is recommended only for selected cases when the diagnosis is challenging using conventional methods.
Periodontitis and thyroid function: A bidirectional Mendelian randomization study
Authors: Gao Yan , Huang Donghai , Liu Yong , Qiu Yuanzheng , Lu Shanhong 
Published: January 2024

AbstractBackground and ObjectivePrevious studies suggest interaction between periodontitis and thyroid function, while the causality has not yet been established. We applied the Mendelian randomization (MR) method to assess bidirectional causal association between periodontitis and thyroid‐related traits, including free thyroxine (FT4), thyroid stimulating hormone (TSH), hypothyroidism, hyperthyroidism and autoimmune thyroid disease (AITD).MethodsGenetic instruments were extracted from large‐scale genome‐wide association studies on normal‐range FT4 (N = 49 269) and TSH (N = 54 288) levels, TSH in full range (N = 119 715); hypothyroidism (discovery/replication cohorts: N = 53 423/334 316), hyperthyroidism (discovery/replication cohorts: N = 51 823/257 552), AITD (N = 755 406) and periodontitis (N = 45 563). Here, the inverse variance weighted (IVW) method was applied as the primary analysis, and robustness of results were assessed by several pleiotropic‐robust methods. Results were adjusted for Bonferroni correction thresholds with significant p < .004 (0.05/13) and suggestive p between .004 and .05.ResultsThe IVW analysis revealed a suggestively causal linkage between genetic predisposition to periodontitis and the increased risk of hypothyroidism (discovery cohort: odds ratio [OR] = 1.24, 95% confidence interval [CI] = 1.05–1.46, p = .012; replication cohort: OR = 1.06, 95% CI = 1.01–1.11, p = .011). No evidence was found for supporting the impact of periodontitis on hyperthyroidism and AITD risks (associated p ≥ .209), as well as thyroid‐related traits on periodontitis risk (associated p ≥ .105). These findings were robust and consistent through sensitivity analysis with other MR models.ConclusionThis bidirectional MR reveals periodontitis should not be attributed to variations in thyroid function but it has potential causal effect on hypothyroidism risk, which provides a better understanding of the relationship between periodontitis and thyroid function, and potential evidence for the clinical intervention of hypothyroidism. Further investigations are warranted to elucidate the nature and underlying mechanisms of this finding.