bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges and success stories of the implementation of infection control and antimicrobial stewardship strategies: proceedings of the 5th Global Ministerial Summit on Patient Safety, 2023
Authors: Büchler Andrea C. , Haddad Galas Murielle , Buetti Niccolò , Alp Emine , Apisarnthanarak Anucha , Dziekan Gerald , Fabre Valeria , Gottwalt Simon , Jindai Kazuaki , Ndoye Babacar , Márquez Villareal Hilda , Otaiza Fernando , Pittet Didier , Schellack Natalie , Gardiol Céline , Harbarth Stephan 
Published: February 2024

AbstractThe 5th edition of the Global Ministerial Summit on Patient Safety was held in Montreux, Switzerland, in February 2023, delayed by three years due to the COVID-19 pandemic. The overarching theme of the summit was “Less Harm, Better Care – from Resolution to Implementation”, focusing on the challenges of implementation of infection prevention and control (IPC) strategies as well as antimicrobial stewardship programs (ASP) around the world. IPC strategies and ASP are of increasing importance due to the substantial burden of healthcare-associated infections and antimicrobial resistance threatening patient safety. Here, we summarize countries’ and regional experiences and activities related to the implementation of IPC strategies and ASP shared at the meeting. Full implementation of effective programs remains a major challenge in all settings due to limited support by political and healthcare leaders, and human and financial constraints. In addition, the COVID-19 pandemic challenged already well-established programs. By enforcing sustained implementation by dedicated, cross-disciplinary healthcare personnel with a broad skill set, a reduction in healthcare-associated infections and multidrug-resistant pathogens can be achieved, leading ultimately to improved patient safety.
Exploring the role of blockchain technology in modern high-value food supply chains: global trends and future research directions
Authors: Chiaraluce Giulia , Bentivoglio Deborah , Finco Adele , Fiore Mariantonietta , Contò Francesco , Galati Antonino 
Published: February 2024

AbstractTrust, safety, and quality are among the most important factors in the agri-food supply chains. Traceability is a powerful tool to ensure them, but implementing a transparent and effective system is a complex operation. As a result, innovative systems, like blockchain, could be introduced. Although research on its impacts in the agri-food is recent, the literature appears fragmented. The objective is to investigate the studied aspects of the blockchain adoption in agri-food, with the purpose of retrieving meaningful considerations about the current state of the art about strategic high-value supply chains, such as wine and olive oil, particularly subjected to fraudulent behaviors. A productivity measurement was applied to retrieve the evolution of the number of documents through the years, the most productive countries, the sources, the research areas, and the most significant papers in terms of number of citations received. To understand the research trends, a co-occurrence analysis was employed. Results show that most of the existing studies focus on the role of blockchain in the resolution of some critical issues as food safety and frauds. While wine is currently an emerging sector in which this approach can be implemented, olive oil still needs more attention. In both cases, blockchain could potentially help to support the profitability and sustainability of the production. The research underlines the importance of focusing on the environmental and social dimension of the blockchain phenomenon and the use of technology to improve the efficiency of agri-food chains and reduce waste and resource use.
Gene expression analysis reveals diabetes-related gene signatures
Authors: Farrim M. I. , Gomes A. , Milenkovic D. , Menezes R. 
Published: February 2024

Abstract
Background
Diabetes is a spectrum of metabolic diseases affecting millions of people worldwide. The loss of pancreatic β-cell mass by either autoimmune destruction or apoptosis, in type 1-diabetes (T1D) and type 2-diabetes (T2D), respectively, represents a pathophysiological process leading to insulin deficiency. Therefore, therapeutic strategies focusing on restoring β-cell mass and β-cell insulin secretory capacity may impact disease management. This study took advantage of powerful integrative bioinformatic tools to scrutinize publicly available diabetes-associated gene expression data to unveil novel potential molecular targets associated with β-cell dysfunction.

Methods
A comprehensive literature search for human studies on gene expression alterations in the pancreas associated with T1D and T2D was performed. A total of 6 studies were selected for data extraction and for bioinformatic analysis. Pathway enrichment analyses of differentially expressed genes (DEGs) were conducted, together with protein–protein interaction networks and the identification of potential transcription factors (TFs). For noncoding differentially expressed RNAs, microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), which exert regulatory activities associated with diabetes, identifying target genes and pathways regulated by these RNAs is fundamental for establishing a robust regulatory network.

Results
Comparisons of DEGs among the 6 studies showed 59 genes in common among 4 or more studies. Besides alterations in mRNA, it was possible to identify differentially expressed miRNA and lncRNA. Among the top transcription factors (TFs), HIPK2, KLF5, STAT1 and STAT3 emerged as potential regulators of the altered gene expression. Integrated analysis of protein-coding genes, miRNAs, and lncRNAs pointed out several pathways involved in metabolism, cell signaling, the immune system, cell adhesion, and interactions. Interestingly, the GABAergic synapse pathway emerged as the only common pathway to all datasets.

Conclusions
This study demonstrated the power of bioinformatics tools in scrutinizing publicly available gene expression data, thereby revealing potential therapeutic targets like the GABAergic synapse pathway, which holds promise in modulating α-cells transdifferentiation into β-cells.
Test review of Iranian English language proficiency test: MSRT test
Authors: Khodi Ali , Ponniah Logendra Stanley , Farrokhi Amir Hossein , Sadeghi Fateme 
Published: February 2024

AbstractThe current article evaluates a national English language proficiency test known as the “MSRT test” which is used to determine the eligibility of candidates for admission to and completion of higher education programs in Iran. Students in all majors take this standardized, high-stake criterion-referenced test to determine if they have obtained the minimum English proficiency level and can be graduated. The present paper seeks to examine the test and its psychometrics characteristics due to the significance of such a high-stakes examination that may have social and long-lasting effects on the participants. It is claimed that the test measures participants’ “knowledge of language” for communication rather than their “knowledge about language” in a constrained context. As a result, the test dimensionality and validity are up for debate. It was found that fundamental revisions in terms of test format and content are required to improve the test quality. The current study examined the areas that are yet unexplored and attempts to describe the MSRT assessment comprehensively.
The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system
Authors: Xu Jinghui , Peng Qianqian , Cai Jieyi , Shangguan Jianghong , Su Wenfeng , Chen Gang , Sun Hualin , Zhu Changlai , Gu Yun 
Published: February 2024

AbstractMyelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required for normal motor function. Here, we show that Gnao1 restricted to Schwann cell (SCs) lineage, but not neurons, negatively regulate SC differentiation, myelination, as well as re-myelination in peripheral nervous system (PNS). Mice lacking Gnao1 expression in SCs exhibit faster re-myelination and motor function recovery after nerve injury. Conversely, mice with Gnao1 overexpression in SCs display the insufficient myelinating capacity and delayed re-myelination. In vitro, Gnao1 deletion in SCs promotes SC differentiation. We found that Gnao1 knockdown in SCs resulting in the elevation of cAMP content and the activation of PI3K/AKT pathway, both associated with SC differentiation. The analysis of RNA sequencing data further evidenced that Gnao1 deletion cause the increased expression of myelin-related molecules and activation of regulatory pathways. Taken together, our data indicate that Gnao1 negatively regulated SC differentiation by reducing cAMP level and inhibiting PI3K-AKT cascade activation, identifying a novel drug target for the treatment of demyelinating diseases.
Pattern recognition of financial innovation life cycle for renewable energy investments with integer code series and multiple technology S-curves based on Q-ROF DEMATEL
Authors: Kou Gang , Dinçer Hasan , Yüksel Serhat 
Published: February 2024

AbstractThe current study evaluates the financial innovation life cycle for renewable energy investments. A novel model is proposed that has two stages. First, the financial innovation life cycle is weighted by the two-generation technology S-curve (TTSC) for renewable energy investments. Second, the TTSC is ranked with integer patterns for renewable energy investments. For this purpose, the decision-making trial and evaluation laboratory (DEMATEL) is considered with q-rung orthopair fuzzy sets (q-ROFSs). A comparative examination is then performed using intuitionistic and Pythagorean fuzzy sets, and we find similar results for all fuzzy sets. Hence, the suggested model is reliable and coherent. Maturity phase 1 is the most significant phase of the financial innovation life cycle for these projects. Aging is the most important period for financial innovation in renewable energy investment projects—renewable energy companies should make strategic decisions after that point. In this situation, decisions should relate to either radical or incremental innovation. If companies do not make decisions during these phases, innovative financial products cannot be improved. As a result, renewable energy companies will not prefer financing products.
‘With a little help from my educated friends’: revisiting the role of social capital for immigrants’ labour market integration in Germany
Authors: Rüdel Julia , Steinmann Jan-Philip 
Published: February 2024

AbstractThis article examines the link between immigrants’ social capital and their labour market access (employment) and success (occupational status) in Germany and contributes to previous research in two ways. Firstly, based on insights from theories of social capital and immigrant integration, we overcome the mere distinction between inter- and intra-ethnic ties. Instead, we approximate resources immigrants can access and mobilize by considering both the ethnic and socioeconomic compositions of their networks. Secondly, by using autoregressive cross-lagged panel models, we properly deal with the methodological challenge of endogeneity inherent to studies concerned with the relationship between social capital and labour market outcomes. Based on longitudinal data from the German Socio-Economic Panel the empirical findings indicate the necessity of considering both the ethnic and socioeconomic compositions of immigrants’ networks—as both have independent effects on immigrants’ labour market integration. We conclude that future research on the relationship between immigrants’ social capital and their economic integration may benefit from approximating resources available through social contacts by considering not only the ethnic dimension but also the socioeconomic dimension of contacts.
Observation of antitumor mechanism of GE11-modified paclitaxel and curcumin liposomes based on cellular morphology changes
Authors: Tang Hailing , Li Lijuan , Wang Baoshan ,   Guangxi Scientific Research Center of Traditional Chinese Medicine
Published: February 2024

AbstractCurcumin and paclitaxel are widely used as anti-tumor hydrophobic model drugs for the designation of smart tumor-targeting nanocarriers and the study of the correlation between structural characteristics of nanoparticles and in vivo therapeutic efficacy. Various signaling pathways on cell growth and proliferation have been comprehensively studied in vitro and in vivo under the action of curcumin and paclitaxel nanoparticles. In this paper, we prepared EGFR-targeted GE11 peptide-modified curcumin and paclitaxel compound liposomes (CUR-PTX@GE11-L). The tumor suppression mechanism of CUR-PTX@GE11-L is observed from the aspects of drug release behavior, changes of cell morphology, liver retention, and tumor-targeting efficiency. We hope it can provide a new vision for the rational construction of smart nanoscale drug delivery system through the observation of cytotoxic effects of CUR-PTX@GE11-L, especially on the cellular morphology change.
Graphical Abstract
Examining attributes of retailers that influence where cannabis is purchased: a discrete choice experiment
Authors: Donnan Jennifer R. , Downey Molly , Johnston Karissa , Najafizada Maisam , Bishop Lisa D. 
Published: February 2024

Abstract
Background
With the legalization of cannabis in Canada, consumers are presented with numerous purchase options. Licensed retailers are limited by the Cannabis Act and provincial regulations with respect to offering sales, advertising, location, maximum quantities, and information sharing in an effort to protect public health and safety. The degree these policies influence consumer purchase behavior will help inform regulatory refinement.

Methods
A discrete choice experiment within a cross-sectional online survey was used to explore trade-offs consumers make when deciding where to purchase cannabis. Attributes included availability of sales/discounts, proximity, product information, customer service, product variety, and provincial regulation. Participants ≥ 19 years old who lived in Canada and purchased cannabis in the previous 12 months were recruited through an online market research survey panel. A multinomial logit (MNL) model was used for the base model, and latent class analysis was used to assess preference sub-groups. Key limitations included ordering effect, hypothetical bias, and framing effect.

Results
The survey was completed by 1626 people, and the base model showed that customer service carried the most weight in purchase decisions, followed by proximity and availability of sales and discounts. There was considerable heterogeneity in preference patterns, with a five-group latent class model demonstrating best fit. Only one group (15% of sample) placed a high value on the store being provincially regulated, while three groups were willing to make a trade-off with regulation to access better customer service, product information, or closer proximity. One group preferred non-regulated sources (24% of sample); this group was also primarily driven by the availability of sales and discounts. Three groups (60.5% of sample) preferred online stores.

Conclusion
This study highlighted that there exists significant diversity with respect to the influence of consumer experiences on cannabis purchase behaviors. Modifications to cannabis retail regulations that focus on improving access to product information as well as reviewing limitations on sales and discounts could have the most impact for shifting customers to licensed retailers.
BRCA mutations: screening for germ-line founder mutations among early-onset Syrian breast cancer patients
Authors: Wahabi Alzahabi Salma , Saifo Maher , Abou Alchamat Ghalia 
Published: February 2024

Abstract
Background
Breast cancer (BC) is the most common female cancers in many countries including Syria. Familial breast cancer or previous family cancer history are considered significant risk factors. Therefore, detecting the prevalence and founder mutations in the population facilitates genetic counselling, risk assessment and the development of a cost-effective screening strategy. In this study, we investigated the three germ-line founder mutations in the BRCA1/2 genes: [NM_007294.4 (BRCA1):c.68_69del (p.Glu23fs), NM_007294.4 (BRCA1):c.5266dup (p.Gln1756fs) and NM_000059.4 (BRCA2):c.5946del (p.Ser1982fs)], to examine their incidence and frequency in early-onset breast cancer cases and determine if they are connected to familial breast cancer. One hundred early diagnosed BC females (≤ 40 years old) with no other type of cancer were recruited. Genomic DNA was isolated from peripheral blood samples, and mutations were investigated using the Amplification-Created Restriction Site (ACRS) method.

Results
The family history of cancer was observed in 61% of the cases, of which 35% were breast cancer; however, none of the screened mutations were detected among BC patients.

Conclusions
The investigated germ-line mutations were not common among Syrian female patients with early-onset BC and were not associated with familial BC. Other mutations in the BRCA1/2 genes or other genes may have a contributing role. Future studies and the need to launch nationwide mutation screening tests for BRCA 1/BRCA2 in the Syrian population are recommended.
Stigma and public attitudes toward euthanasia or assisted suicide for psychiatric conditions: results from a general population survey in Germany
Authors: Schomerus Georg , Schindler Stephanie , Baumann Eva , Angermeyer Matthias C. 
Published: February 2024

Background
With growing numbers of countries legalizing euthanasia or assisted suicide (EAS), there is a debate as to whether EAS should also be available to people with severe, treatment-resistant mental illness. Excluding mental illness as a legitimate reason to receive EAS has been framed as discriminating against people with mental illness.

Aims
We examine whether approval or opposition to psychiatric EAS are related to stigma toward people with mental illness.

Method
We asked a representative sample of the general population in Germany (N = 1515) whether they would approve of EAS for someone with severe, treatment-resistant mental illness. Stigma was assessed with the Value-Based Stigma Inventory (VASI), addressing rejection of people with mental illness in relation to different personal values.

Results
A total of 19% of the German population approved of psychiatric EAS. Higher stigma scores were associated with greater approval of EAS (Spearman rank correlation coefficient, 0.28; P < 0.001). This association held true when controlling for sociodemographic variables. It was strongest for stigma related to perceived threats to one's security, reputation and meritocratic values.

Conclusions
Our results highlight that, although opposing psychiatric EAS is sometimes framed as discriminatory, approval of psychiatric EAS might also carry hidden, stigmatising motives. To avoid any unintended negative consequences for people with severe, treatment-resistant mental illness, any legislation on psychiatric EAS needs to be crafted with particular caution.
Liver Androgen Receptor Knockout Improved High-fat Diet Induced Glucose Dysregulation in Female Mice But Not Male Mice
Authors: Osei-Ntansah Adjoa , Oliver Trinitee , Lofton Taylor , Falzarano Claire , Carr Kiana , Huang Ruthe , Wilson Andre , Damaser Ella , Harvey Guyton , Rahman Md Ahasanur , Andrisse Stanley 
Published: February 2024

Abstract
Previous research has indicated that liver androgen receptors may play a role in modulating disease. This study aims to investigate the pathophysiology of high-fat diet (HFD) induced dysglycemia in male and female liver androgen receptor knockout (LivARKO) mice. We performed metabolic tests on LivARKO female and male mice fed a HFD or a control diet (from Research Diets Inc.) during months 1 or 2 after starting the diet. Additionally, we performed Western blot and quantitative real-time PCR analysis on the livers of the mice to examine intermediates in the insulin signaling pathway. LivARKO-HFD female mice displayed no difference in glucose tolerance compared to female LivARKO-Control (Con) mice, whereas in wild-type female mice, HFD impaired glucose tolerance (IGT). Our data suggests that starting at 1 month, LivARKO may be protecting female mice from HFD-induced metabolic dysfunction. LivARKO-HFD female mice displayed significantly worse insulin sensitivity at 15 minutes compared to LivARKO-Con female mice, but, strangely, LivARKO-HFD female mice had significantly better insulin sensitivity at 60 and 90 minutes compared to LivARKO-Con female mice. Despite protecting against IGT, LivARKO did not protect against HFD-induced hyperinsulinemia in female mice. In contrast to females, male LivARKO-HFD mice displayed impaired glucose tolerance compared to male LivARKO-Con mice. Thus, LivARKO is not protective against HFD-induced glucose metabolic dysfunction in male mice. Lastly, LivARKO-HFD female mice maintained hepatic insulin sensitivity whereas LivARKO-HFD male mice displayed hepatic insulin resistance. These findings suggest that LivARKO delayed the onset of HFD-induced dysglycemia in female mice.
La abominación de lo híbrido: la mixofobia como política de estado.
Authors: Rodríguez García Dan 
Published: February 2024

The article discusses a number of historical cases of nations that have developed anti-miscegenation laws premised on a logic of “state mixophobia”, with instances as diverse as the Spanish colonization of the Americas and later of Equatorial Guinea; England and Australia during the colonial and postcolonial eras; the United States in the nineteenth and twentieth centuries;
Germany during the Nazi period; and South Africa under apartheid. I argue that in all of these cases, hybridity represented not so much the danger of external enemies, but rather the destruction of internal borders: that is, a threat to the socio-political and economic status quo.
This historical-anthropological analysis can help us in today’s world to better understand and reflect critically on the social, political, and economic contexts in which reductionist views of hybridity emerge and are used to legitimize social systems of exclusion.
Democracy and Climate Change a Confucian Proposal
Authors: De Prada Aurelio 
Published: February 2024

Democracy is one of the West’s most important contributions to universal human heritage. Still it presents some drawbacks in the ways it relates to certain global problems, especially climate change. In this paper we claim that these drawbacks can be ameliorated by turning to a non-Western tradition, specifically to Confucianism. A tradition that, first of all, we will have to analyze in its proper terms – i.e. in ideographical ones –, in order to relate it, afterwards, to democracy in what concerns climate change. Finally, we will propose a synthesis – what we call 君人, individual and king –, introducing in the concept of democracy the idea of harmony between nature and society. In other terms, we will defend a royal/real democracy, in which the political subject would be individual 人and king 君at the same time.