bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing the sustainable urbanism paradox: tipping points for the operational reconciliation of dense and green morphologies.
Authors: Boutreux Thomas , Bourgeois Marc , Bellec Arnaud , Commeaux Fabien , Kaufmann Bernard 
Published: November 2023

Abstract

To improve living conditions of biodiversity and humans, urban forms must reconcile density with vegetation to meet the dual challenge of sustainability and liveability. This sustainable urbanism paradox is a dilemma for practitioners and researchers, stressing the crucial need for comprehensive analyses. Multi-family residential (MFR) housing could achieve balanced density-greening, proximity ecosystem services and people-biodiversity interactions, but meeting such objectives relies on finding balanced morphologies and metrics at the operational scale. Based on a systemic approach of 11,593 MFR plots in the Lyon metropolitan area (France), we identified critical tipping points in morphology and greening. Density explained 6% of plot greening, while open space ratio and open space greening explained 94%. Open space ratio >0.5 was found to be a tipping point to achieve sustainable green supply. Operational morphologies balancing density and greening were modelled and illustrated across building heights, providing guidelines for emerging regulatory tools in sustainable urban planning.
Dual Interstitials Doping to Advance PbSe Thermoelectric at Wide Temperatures
Authors: Xiao Yu , Xu Liqing , Wang Xiaoying , Gao Zhibin , Ding Xiangdong , Wang Yang 
Published: November 2023

Abstract
Interstitial doping has been widely verified in optimizing thermoelectric performance due to its carrier and phonon decoupling effect. To maximize the role of interstitial, this work develops a novel strategy of Pb and Cu dual interstitials doping in n-type Pb1.02Se-0.2%Cu, and a considerably improved average ZT value of 1.01 at 300–773 K can be achieved, which obviously outperforms previous single interstitial doped PbSe systems. Its superior thermoelectric performance mainly originates from optimally tuned carrier and phonon transport properties caused by synergy of Pb and Cu dual interstitials. Firstly, Pb and Cu dual interstitials in n-type Pb1.02Se-0.2%Cu can fully optimize temperature-dependent carrier density in the whole temperature range, from 1.27×1019 cm− 3 at 300 K to 3.90×1019 cm− 3 at 773 K, thus contributing to maximal power factor of 32.83 µW cm− 1 K− 2 and average power factor of 24.18 µW cm− 1 K− 2. Furthermore, Pb and Cu dual interstitials doping can cause hierarchical defects, including interstitials, vacancies, dislocations and precipitates, thus to largely lower the lattice thermal conductivity. As a result of the optimized electrical and thermal transport properties, the thermoelectric performance in n-type Pb1.02Se-0.2%Cu is largely enhanced at wide temperatures.
Study on Composite Material Drilling with Step Elliptical Sphere-Core Drill (SESCD)
Authors: Liao Shao-Sen , Liao Kang-Yu , Li Cheng-En , Lai Tsung-Yi , Tsao chung-chen 
Published: November 2023

Abstract
The increase in environmental awareness, energy saving and carbon reduction means that demand for advanced materials for high-tech industries is increasing. Composite materials are widely used in structural components for various industrial applications because they feature light weight, high strength, corrosion resistance and high durability. For final assembly processes for these composite material structural components (CMSCs), hole-drilling using a twist drill (TD) is a fast and inexpensive process. A step elliptical sphere-core drill (SESCD), which is a special compound drill, is composed of a TD and an elliptical sphere-core drill (ESCD). It prevents chip jamming and reduced thrust force at the exit hole better than a step sphere-core drill (SSCD. Studies also show that CMSCs can delaminate during drilling if the thrust force is too great. This study determines the difference in the critical thrust force (CTF) for a SESCD and a TD for drilling composite materials. The results show that the CTF for a SESCD is increased by ~75% if s>0.84 over that for a TD for various values of β (the ratio between the thickness of the ESCD (t) and the radius of the ESCD (c)). This design for a SESCD increases the drilling quality of composite materials and allows future tool innovation.
Behavioral health outcomes and social determinants of health in children with diabetes and juvenile arthritis
Authors: Lupini Francesca , Rubinstein Tamar B , Mackey Eleanor R , Sule Sangeeta 
Published: November 2023

Abstract
Objective: Children with chronic illnesses, including arthritis, are at increased risk for adverse psychosocial outcomes influenced by social determinants of health (SDOH). Comparing psychosocial outcomes in families affected by juvenile arthritis compared to other chronic illnesses may help identify areas in need of special attention vs areas that may be addressed through adopting other disease examples’ care models. We examined child and parent behavioral health outcomes for families with juvenile arthritis compared to diabetes, accounting for SDOH.
Methods Secondary data analysis of the National Survey of Children’s Health including 365 children (<18yrs) with arthritis and 571 children with diabetes. Psychosocial outcomes were depression, anxiety, ADHD, physical pain, behavioral problems, and treatment for mental health. School outcomes were school engagement, school absence, involvement in clubs/organization, and involvement in organized activities. Parent outcomes were family resilience, emotional support, coping with daily demands of raising a child, job change due to problems with childcare, and parent mental health. SDOH variables were food insecurity, food/cash assistance, unsafe neighborhood, detracting neighborhood elements, parent education, households earning <100% of the federal poverty line. Logistic regression analyses were utilized to examine variation in child and parent outcomes, variation in SDOH, and the role of SDOH.
Results Children with arthritis experienced significantly more physical pain, anxiety, depression, ADHD, and behavior problems compared to children with diabetes. Children with arthritis were more likely to see a mental health professional and get treatment for problems with emotions/behaviors. When considering SDOH, children with arthritis were still more likely to experience adverse psychosocial outcomes but were no longer more likely to get treatment. Children with arthritis had increased likelihood of school absence and were less involved in organized activities than children with diabetes. Parents of children with arthritis had poorer mental health than parents of children with diabetes. SDOH were more prevalent in children with arthritis than children with diabetes.
Conclusions Increased risk for adverse psychosocial outcomes in youth with arthritis compared to youth with diabetes indicates a need to mirror endocrinology models of care in rheumatology clinics. The role of SDOH highlights the need for regular SDOH screening in clinic.
Whole transcriptome RNA-Seq reveals drivers of pathological dysfunction in a transgenic model of Alzheimer’s disease
Authors: Potemkin Nikita , Cawood Sophie , Guévremont Diane , Mockett Bruce , Treece Jackson , Stanton Jo-Anne , Williams Joanna 
Published: November 2023

Abstract
Alzheimer’s disease (AD) affects more than 55 million people worldwide, yet current theories cannot fully explain its aetiology. Accordingly, gene expression profiling has been used to provide a holistic view of the biology underpinning AD. Focusing primarily on protein-coding genes, such approaches have highlighted a critical involvement of microglia-related inflammatory processes. Simultaneous investigation of transcriptional regulators and noncoding RNA (ncRNA) can offer further insight into AD biology and inform development of disease modifying therapies. We previously described a method for whole transcriptome sampling to simultaneously investigate protein-coding genes and ncRNA. Here, we use this technique to explore transcriptional changes in a murine model of AD (15-month-old APP/PS1 mice). We confirmed extensive involvement of microglia-associated genes and gene networks, consistent with literature. We also report a wealth of differentially-expressed non-coding RNA – including microRNA, long non-coding RNA, small nuclear and small nucleolar RNA, and pseudogenes – many of which have been overlooked previously. Transcription factor analysis determined that six transcription factors likely regulate gene expression changes in this model (Irf8, Junb, c-Fos, Lmo2, Runx1, and Nfe2l2). We then utilised validated miRNA-target interactions, finding 60 interactions between 15 miRNA and 42 mRNA (messenger RNA) with largely consistent directionality. Furthermore, we found that eight transcription factors (Clock, Lmo2, Runx1, Nfe2l2, Egr2, c-Fos, Junb, and Nr4a1) are likely responsible for the regulation of miRNA expression. Taken together, these data indicate a complex interplay of coding and non-coding RNA, driven by a small number of specific transcription factors, contributing to transcriptional changes in 15-month-old APP/PS1 mice.
Pathogenic taxa constitute a substantial portion of bat and wild bird fecal bacterial microbiota
Authors: Poosakkannu Anbu , Xu Yanjie , Suominen Kati , Meierhofer Melissa , Sørensen Iben , Madsen Jesper , Plaquin Betty , Guillemain Matthieu , Joyeux Emmanuel , Keiss Oskars , Lilley Thomas , Lehikoinen Aleksi , Pulliainen Arto 
Published: November 2023

Abstract
We report European-wide characteristics of fecal bacterial microbiota of four migratory vertebrates. The 351 sample PacBio dataset of almost the entire 16S rRNA gene on one bat (Pipistrellus nathusii) and three bird species (Turdus merula, Anas platyrhynchos, Columba palumbus) with 438,997 amplicon sequence variants assigned 3,277 bacterial species. Plant pathogens were frequently detected, in particular with bat, e.g., Erwinia persicina and Pseudomonas syringae. Also, >90% of the PacBio reads were assigned in 36 samples to genera having species pathogenic to human or animals, e.g., the well-known or emerging enteropathogens Campylobacter jejuni and Escherichia marmotae. We designate individuals of these 36 samples as pathogen bloomers, i.e., previously unknown high risk sources of pathogen spillover. Statistically, more pathogen PacBio reads were detected at higher latitudes and in younger age groups. The studied highly mobile vertebrates appear as a potential concern for human, animal and plant health across the European continent.
Robust design optimization of structures with multimodal responses using Taylor expansions
Authors: Kriegesmann Benedikt , Krüger Jan , Steltner Kai 
Published: November 2023

Abstract

This paper shows how a combination of multiple linear approximations can efficiently capture non-linear and non-smooth response functions in the framework of robust design optimization. The basic idea is to split the domain of random parameters into multiple subdomains along the hypersurfaces that cause discontinuities in the response. For each subdomain, a linear approximation is used to determine the stochastic moments of the response function due to the scatter in that subdomain. The total stochastic distribution of the structural response is considered to be a multimodal distribution, and its moments are composed from the approximations in the subdomains. The application to use cases shows that indeed the structural response is multimodal in these cases, and the stochastic moment approximations are sufficiently accurate using the proposed method.
Study on the mode of Elderly Tourism &amp; Dwelling in Zhejiang traditional village based on push and pull theory
Authors: Li Ya 
Published: November 2023

Abstract
Against the backdrop of the aging population and the urgent need for protection and development of traditional villages, how to alleviate the pressure of urban elderly care and diversify the industries of tradition villages has become an important social issue that needs to be urgently studied. As a new type of elderly care, the elderly tourism & dwelling industry can not only effectively share the pressure of urban elderly care, but also promote the transformation and upgrading of traditional village industry and assist in the strategy of rural revitalization. This paper takes the push and pull theory as the research perspective, viewing the traditional village elderly tourism & dwelling industry as a push and pull process. Through the research on the typical traditional villages in Zhejiang, we analyzed the "push" of the city, the "pull" of the traditional villages, and the "intermediate obstacles" factors of the elderly tourism & dwelling industry. According to the push and pull theory, the relationship between elderly tourism & dwelling industry in rural areas and the protection of traditional villages is a dialectical unity. On the one hand, with the increasingly serious trend of urban aging and insufficient public resources in cities, forming urban push factors, on the other hand, traditional villages need to achieve diversified development with the help of the elderly tourism & dwelling industry, which forms the pull factor of traditional villages, while the intermediate obstacle factor gradually weakens with the influence of social development. On the basis of analyzing the push and pull factors, the SWOT analysis method is used to elaborate the opportunities and deficiencies faced by traditional villages in Zhejiang Province in developing the elderly tourism & dwelling industry, and put forward the development countermeasures, with a view to providing theoretical guidance for the development path and planning practice of the tourism and dwelling industry in Zhejiang Province.
Bioinformatic gene analysis for potential biomarkers and therapeutic targets of Parkinson's disease based on neutrophil extracellular traps
Authors: Wang Xueping , Gu Youquan , Liu Xiaoyan , Wang Qiang , Chen Xie , Chen Jun 
Published: November 2023

Abstract

Neutrophil extracellular traps (NETs) provide key innate immune mechanisms, and studies have shown innate immunity and adaptive immunity are directly linked in Parkinson’s disease (PD) pathology. However, there are few studies on NETs in PD. Differential analysis was implemented to acquire differentially expressed genes (DEGs) between PD and Control, and between high- and low-score groups obtained by GSVA. Then, the DEGs between PD and Control groups, DEGs between the two score groups, and the genes in the critical module were overlapped to achieve the overlapping genes. Next, five kinds of algorithms in the PPI were performed to achieve biomarkers. Subsequently, a nomogram for forecasting PD probability was created. Enrichment analysis and immune infiltration analysis was conducted of biomarkers. qRT-PCR was performed to verify the expression trends of three biomarkers. Results shown there were 798 DEGs between PD and Control groups and 168 DEGs between high- and low-score groups obtained by differential analyses. The pink module containing 926 genes was identified as the critical module. According to the intersection, 43 overlapping genes were screened out. Furthermore, GPR78, CADM3, and CACNA1E were confirmed as biomarkers. Moreover, we found that biomarkers mainly participated in pathways, such as ‘hydrogen peroxide catabolic process’ and ‘cell cycle’. Five kinds of differential immune cells between PD and Control groups were identified. Finally, the qRT-PCR result showed that GPR78, CADM3, and CACNA1E all up-regulated in the PD group. Our study authenticated GPR78, CADM3, and CACNA1E as the biomarkers were associated with PD. It provides an original reference for the diagnosis and treatment of PD.
Inflammatory bowel disease and Pancreatitis: A Two-Sample Mendelian Randomization Study
Authors: Dai Qijie , Cen Jiepeng , Lu Weipeng , Ni Ziyan , Tao Heqing , Peng Liang 
Published: November 2023

Abstract

Background
Increasing reports about the association between inflammatory bowel disease (IBD) and pancreatitis have suggested these years. Thus, a two-sample mendelian randomization (MR) study performed to evaluate the causal association between IBD and pancreatitis is necessary.
Methods
We performed univariate two-sample MR and respectively selected single nucleotide polymorphisms (SNPS) associated with IBD, ulcerative colitis (UC), Crohn's disease (CD), acute pancreatitis (AP), and chronic pancreatitis (CP) as instrumental variables (IV). The inverse-variance-weighted method (IVW), MR-Egger, weight mode, simple mode, and weighted median were used in MR analyses, among which IVW is the most important method. Subsequently, the Cochran's Q test, MR-Egger intercept test, leave one-out analyses and funnel plot were used in the sensitivity analysis.
Results
Genetically predicted IBD was positively associated with risk of AP (odds ratio (OR) = 1.062; 95% confidence intervals (CI), 1.01 − 1.11; p = 0.007) and CP (OR = 1.06; 95% CI, 1.00 − 1.13; p = 0.04). Genetically determined UC was suggestively associated with AP (OR = 1.08; 95% CI, 1.03–1.13; p = 0.001), but not CP (OR = 1.00; p = 0.812), and likewise, genetically determined CD was positively correlated with AP (OR = 1.04; 95% CI, 1.00–1.08; p = 0.019), but not CP (OR = 1.04; p = 0.111). It was certified that the results were robust through sensitivity analyses.
Conclusion
Our results identified the causal relationship between IBD and AP/CP, as well as UC/CD and AP, which may influence clinical decisions on the management of IBD patients with pancreatic symptoms.
Task Difficulty Modulates the Effect of Eye Contact on Word Memory
Authors: Feng Xinghe , Hu Qiqi , Ye Chaoxiong , Hu Zhonghua 
Published: November 2023

Abstract

The influence of eye contact on memory has been a topic of extensive study, yet its effects remain ambiguous. This inconsistency may be attributed to the varying levels of task difficulty encountered during such research. To explore this possibility, our study employed a word memory task, integrating eye gaze, to examine how task difficulty (easy or difficult) modulates the effect of eye contact on word memory. 41 participants engaged in memory tasks under varying eye contact conditions. Our findings reveal a significant interaction between task difficulty and eye contact: for easy tasks, memory accuracy was lower with eye contact, whereas for difficult tasks, accuracy improved in the presence of eye contact. Intriguingly, this effect was predominantly observed in female participants. In easy tasks, eye contact appeared to hinder memory performance in females, while it enhanced performance in difficult tasks. These results suggest that the impact of eye contact on memory is not uniformly positive or negative but is contingent on task complexity and is influenced by gender differences. This study contributes new insights into the fluctuating effects of eye contact on memory, thereby enriching our understanding of the relationship between non-verbal social cues and cognitive processes.
Using targeted next-generation sequencing to diagnose severe pneumonia due to Tropheryma Whipplei and Human Metapneumovirus:a case report and literature review
Authors: Liu Fang , Yang Xuyong , Ouyang Chenghong , He Zhaohui , Yang Chunli , Yang Xiaogang 
Published: November 2023

Abstract
Background: In addition to the well-known Whipple’s disease (WD)，infection with Tropheryma whipplei(TW) can also lead to acute pneumonia, but due to the lack of specific clinical manifestations and diagnostic measures, diagnosing TW-related pneumonia is extremely difficult.
Clinical Presentation and Intervention: This is an elderly patient with multiple injuries caused by falling from a building, and was transferred to intensive care unit (ICU)for mechanical ventilation and empirical anti-infection treatment due to severe hospital-acquired pneumonia(HAP), and then the patient's bronchoalveolar lavage fluid (BALF) targeted next-generation sequencing (tNGS) suggested TW and human metapneumovirus(HMPV) infection, and after switching to anti-infective therapy for TW, the patient was successfully extubated and transferred out of the ICU.
Conclusion: This is the first case that using tNGS to diagnose severe pneumonia caused by TW and HMPV. We hope that our study can serve as a reference for the diagnosis and treatment of related cases in the future.
Understanding the Determinants of Sweet Liking in the African and East Asian Ancestry Groups in the U.S. – A Study Protocol
Authors: Cheung May M , Hubert Patrice A , Reed Danielle R , Pouget Enrique R , Jiang Xinyin , Hwang Liang-Dar 
Published: November 2023

Abstract
Background
The liking for sweet taste is a powerful driver for consuming added sugars, and therefore, understanding how sweet liking is formed is a critical step in devising strategies to lower added sugars consumption. However, current research on the influence of genetic and environmental factors on sweet liking is mostly based on research conducted with individuals of European ancestry. Whether these results can be generalized to people of other ancestry groups warrants investigation.
Methods
We will determine the differences in allele frequencies in sweet-related genetic variants and their effects on sweet liking in 426 adults of either African or East Asian ancestry, who have the highest and lowest average added sugars intake, respectively, among ancestry groups in the U.S. We will collect information on participants’ sweet-liking phenotype, added sugars intake (sweetness exposure), anthropometric measures, place-of-birth, and for immigrants, duration of time living in the U.S. and age when immigrated. Ancestry-specific polygenic scores of sweet liking will be computed based on the effect sizes of the sweet-related genetic variants on the sweet-liking phenotype for each ancestry group. The predictive validity of the polygenic scores will be tested using individuals of African and East Asian ancestry from the UK Biobank. We will also compare sweet liking between U.S.-born individuals and immigrants within each ancestry group to test whether differences in environmental sweetness exposure during childhood affect sweet liking in adulthood.
Discussion
Expanding genetic research on taste to individuals from ancestry groups traditionally underrepresented in such research is consistent with equity goals in sensory and nutrition science. Findings from this study will help in the development of a more personalized nutrition approach for diverse populations.
Trial registration:
This protocol has been preregistered with the Center for Open Science (https://doi.org/10.17605/OSF.IO/WPR9E) and is approved by the City University of New York Human Research Protection Program (IRB#: 2023-0064-Brooklyn).