bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between pericardial effusion and aortic dissection in a patient with endothelial damage and permeability caused by Takayasu arteritis: a case report
Authors: Mitsuishi Atsuyuki , Tao Miyako , Edo Naoki , Miura Yujiro , Saitou Ren 
Published: November 2023

Abstract
Background
Patients with Takayasu arteritis (TA) can present with aortic dissection (AD). Pericardial effusion is extremely rare in TA, and the association between pericardial effusion and progression to AD is unclear.
Case presentation:
We present a 51-year-old male patient who had a previous history of ulcerative colitis 20 years ago and who was treated with steroids and immunosuppressants. His fever and inflammatory reaction worsened without gastrointestinal symptoms. Based on his fluorodeoxyglucose-positron emission tomography and computed tomography scan results and clinical symptoms, he was diagnosed with TA. Eight days before surgery, the patient developed complete atrioventricular block, and a pacemaker was placed. Coronary artery computed tomography scan was performed to closely examine the coronary arteries. Ascending AD was discovered incidentally, and ascending aortic replacement was performed.
Conclusions
Some patients with TA exhibited high levels of vascular endothelial growth factor (VEGF), which was produced as a result of endothelial damage associated with disease activity. Patients showed high disease activity soon after the diagnosis of TA. VEGF increases vascular permeability and can cause pericardial effusion, similar to AD pathogenesis. As intimal rupture is one of the initial events of AD, changes in the intimal structure result in endothelial cell dysfunction, thereby increasing vascular endothelial permeability, which is a mechanism of pericardial effusion in AD. Pericardial effusion in AD is an ominous clinical predictor of poor outcomes and is the leading cause of mortality. Because TA with pericardial effusion may have a similar pathogenesis and vascular condition in AD, caution should be exercised when pericardial effusion is noted in patients with TA, which could be a sign of high vascular activity that possibly progresses to AD, especially immediately after diagnosis. Hence, cautious follow-up via computed tomography may be useful.
Stage-Wise Data Balancing Promoting Toe-tapping-based Classification of Parkinson's Disease Progression using Smart Insoles
Authors: Wang Ya , Hua Rui , Almuteb Ibrahim 
Published: November 2023

Abstract
Given the slow progression nature of Parkinson's Disease (PD), accurate stage classification is predominant for effective disease management. Traditional clinical evaluations, often based on brief physician-patient interactions, can miss nuanced disease progressions. With their continuous monitoring capabilities and bolstered by recent machine learning (ML) advancements, wearable devices such as monitoring insoles (MONI) present a promising solution. However, capturing a comprehensive dataset spanning all PD stages is challenging, leading to data imbalances. These imbalances can cause ML models to favor the majority class, achieving high accuracy but compromising clinical relevance. To address this inherent challenge in PD data, we identified two most effective sampling methods: Synthetic Minority Over-sampling Technique (SMOTE) and Tomek-Links. We compared their data balance performance using toe-tapping datasets collected from PD patients and their age-matched healthy controls (HC) wearing MONI. Additionally, we utilized SHapley Additive exPlanations (SHAP) for ranking to ascertain each technique's efficacy and verify the top factors contributing to PD stage classification, relating these factors to the underlying mechanisms or symptoms of PD. Data balancing enhanced stage classification by 5-7% compared to the original dataset. Our findings show that with SMOTE and Tomek-Links balanced data, we were able not only to improve the accuracy and robustness of stage classification but also observed the model emphasizing features that have a direct relation to each stage rather than favoring the HC majority class, thus ensuring a model is tailored to the PD domain.
Ki-67 labeling index predicts tumor progression patterns and survival in patients with atypical meningiomas following stereotactic radiosurgery
Authors: Umekawa Motoyuki , Shinya Yuki , Hasegawa Hirotaka , Morshed Ramin A. , Katano Atsuto , Shinozaki-Ushiku Aya , Saito Nobuhito 
Published: November 2023

Abstract
Purpose
This study investigated whether Ki-67 labeling index (LI) correlated with clinical outcomes after SRS for atypical meningiomas.
Methods
This retrospective study examined 39 patients with atypical meningiomas who underwent SRS over a 10-year study period. Ki-67 LI was categorized into 3 groups: low (< 5%), intermediate (5–10%), and high (> 10%). Local tumor control rates (LCRs), progression-free rates (PFRs), disease-specific survival (DSS) rates, and adverse radiation-induced events (AREs) were evaluated.
Results
The median follow-up periods were 26 months. SRS was performed at a median prescription dose of 18 Gy for tumors with a median Ki-67 LI of 9.6%. The 3-year LCRs were 100%, 74%, and 25% in the low, intermediate, and high LI groups, respectively (p = 0.011). The 3-year PFRs were 100%, 40%, and 0% in the low, intermediate, and high LI groups (p = 0.003). The 5-year DSS rates were 100%, 89%, and 50% in the low, intermediate, and high LI groups (p = 0.019). Multivariable Cox proportional hazard analysis showed a significant correlation of high LI with lower LCR (hazard ratio [HR], 3.92; 95% confidence interval [CI], 1.18–13.04, p = 0.026), lower PFR (HR, 3.80; 95% CI, 1.46–9.88, p = 0.006), and shorter DSS (HR, 6.55; 95% CI 1.19–35.95, p = 0.031) compared with intermediate LI. The ARE rates were minimal (8%) in the entire group.
Conclusion
Patients with high Ki-67 LI showed significantly more tumor progression and tumor-related death. Ki-67 LI might offer valuable predictive insights for the post-SRS management of atypical meningiomas.
Endometriosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study
Authors: Huang Pingping , Wang Yifei , Liu Yicheng , Zhang Hongwei , Fu Shuangqing , Zhang Zhibo , Guo Lijun , Ma Xiaochang 
Published: November 2023

Abstract
Background
Observational studies have shown associations between endometriosis and cardiovascular disease (CVD). But residual confounding and the potential for reverse causality are inevitable in such routine observational studies. This study used Mendelian randomization (MR) design to evaluate the causal effect of endometriosis on CVD including coronary heart disease (CHD), myocardial infarction (MI), atrial fibrillation (AF), heart failure (HF), hypertension and Stroke.
Methods
We utilized publicly available summary statistics of genome-wide association studies (GWAS) from European participants in the UK Biobank and Finnish databases. Instrumental variables (IVs) associated with endometriosis and CVD were identified and used IVs to investigate the genetic causal relationship between them. MR analyses were performed using various analytical methods, including Inverse variance weighted (IVW), MR-Egger, and Weighted Median. Tests for pleiotropy and heterogeneity were performed to assess the reliability of causality.
Results
MR analysis showed that endometriosis was associated with hypertension (odds ratio (OR) = 0.9990, 95% confidence interval (CI) : 0.9981–0.9998, P = 0.0191), which may be a protective factor. However, this significance disappeared after applying the Bonferroni correction. Endometriosis was identified as a risk factor for CHD (OR = 1.0025,95%CI: 1.0005–1.0046, P = 0.0164), but this significance was lost after Bonferroni correction. Endometriosis was identified as a risk factor for MI (OR = 1.0018, 95%CI: 1.0005–1.0032, P = 0.0058), which remained significant after Bonferroni correction. Genetic associations between endometriosis and other CVD were not significant.
Conclusions
MR studies have shown that genetic predisposition to endometriosis is significantly associated with the risk of myocardial infarction, and may be associated with the risk of CHD and hypertension. However, the causal relationships between endometriosis and AF, HF and Stroke need to be further explored.
Evaluating adherence, tolerability and safety of oral calcium citrate in elderly osteopenic subjects: a real-life non-interventional, prospective, multicenter study
Authors: Rondanelli Mariangela , Minisola Salvatore , Barale Marco , Barbaro Daniele , Mansueto Francesca , Battaglia Santina , Bonaccorsi Gloria , Caliri Santina , Cavioni Alessandro , Colangelo Luciano , Corbetta Sabrina , Coretti Federica , Dito Giorgia , Gavioli Valentina , Ghigo Ezio , Giannattasio Raffaele , Lapi Paola , Maiorana Blas , Marra Costanza , Mazzantini Maurizio , Morini Elisabetta , Nannipieri Fabrizio , Nuzzo Vincenzo , Parri Fabiana , Perna Simone , Santori Rachele , Procopio Massimo 
Published: November 2023

Abstract
Background: Osteoporosis is a common concern in the elderly that leads to fragile bones. Calcium supplementation plays a crucial role in improving bone health, reducing fracture risk, and supporting overall skeletal strength in this vulnerable population. However, there is conflicting evidence on the safety of calcium supplements in elderly individuals.
Aim: The aim of this study was to evaluate the adherence, safety and tolerability of calcium citrate supplementation in elderly osteopenic subjects.
Methods: In this non-interventional, prospective, multicenter study, subjects received daily 500 mg calcium citrate supplementation for up to one year. Adherence was calculated based on compliance and persistence. Safety was assessed through adverse reactions (ARs), deaths, and clinical laboratory evaluations.
Results: A total of 268 Caucasian subjects (91.4% female, mean age 70±4.5 years) participated in the study. Mean adherence to treatment was 76.6±29.5% and half of subjects had an adherence of 91% and ~33% of participants achieved complete (100%) adherence. ARs were reported by nine (3.9%) subjects, primarily gastrointestinal disorders, with no serious ARs. The frequency of all adverse events (including ARs) was significantly higher in subjects with adherence of <80% (41.6%; 32/77) vs. those with adherence ≥80% (11%; 16/45, p<0.0001). Both systolic and diastolic blood pressure decreased from baseline to follow-up visit (change of -2.8±13.9 mmHg, p=0.0102 and -2.1±10.4 mmHg, p=0.0116, respectively).
Conclusion: This study demonstrated favorable adherence to calcium citrate supplementation in elderly osteopenic subjects. The occurrence of ARs, though generally mild, were associated with lower adherence to calcium supplementation.
Ecotoxicological effects of a glyphosate-based herbicide on Gryllus (Gryllus) assimilis (Orthoptera: Gryllidae) ontogeny: A study on antioxidant system, oxidative stress and cholinergic system
Authors: Macarini Leanna Camila , Guimarães Ana Tereza Bittencourt , Szinwelski Neucir 
Published: November 2023

Abstract

Brazil is an important global agricultural producer and to increase production the country has extensively used glyphosate-based herbicides (GBH), surpassing consumption and sales records. Consequently, concerns have arisen regarding the potential impact of GBH on ecosystems and non-target organisms. Thus, the effects of GBH exposure were evaluated throughout the cricket Gryllus (Gryllus) assimilis ontogeny, with five developmental stages. Each period contained 3 control and 3 treated boxes, with 15 crickets each, resulting in 90 insects at a time. The control groups received water, while the treated ones were continuously exposed to GBH (0.864 mg.GBH.L-1), with the solutions changed every 48 hours. After each exposure time the crickets’ group were euthanized to assess the activity of antioxidant enzymes (GST, GR, GPx, and CAT), cholinergic enzymes (ChE), and lipid peroxidation (LPO). The results revealed changes in the systems throughout different developmental phases. Specifically, CAT activity exhibited a significant increase during the nymphal phase, associated with the dismutation of hydrogen peroxide. The GST increased GBH, indicating its role in cellular detoxification, particularly during adulthood. In the senescence stage there was a considerable rise in ChE enzymes, suggesting their involvement in both, choline esters breakdown and potential pesticide detoxification. The action of these enzymes to effectively control lipid peroxidation shows the adaptability of this species to environmental contamination. These findings underscore the long-term effects of agrochemical pollution and emphasize the importance of sustainable practices, effective regulations, and alternative weed control methods.
Developing Appropriate Learning Behaviors in L2 Learners: Investigating the Impact of Consciousness Raising Tasks on Recall and Retention of Collocations
Authors: Isaee Hossein , Barjesteh Hamed 
Published: November 2023

Abstract
The purpose of this study was to investigate the impact of consciousness-raising tasks on Iranian EFL learners’ ability to recall and retain collocations. The study analyzed 60 female students aged between 18 and 25, who were at an intermediate level of English. They were selected from a language school in Tehran, Iran, and were homogeneous in terms of their language proficiency. A piloted sample of the Preliminary English Test (PET) was given to both intact classes. The experimental and control groups were randomly assigned, with 30 students in each. To ensure that both groups had equal knowledge of collocations, they were given a teacher-made multiple-choice test of collocations as a pretest. The treatment group received corrective feedback, such as clarification requests, repetitions, and meta-linguistic clues. The control group received the same instruction without feedback. After an eight-week treatment period, both groups were tested on their ability to recall collocations with an immediate post-test. One month later, the researchers gave the experimental group a delayed posttest to see how well they retained the learned grammatical collocations. The participants in the experimental group shared their thoughts and feelings about the effectiveness of the consciousness-raising (C-R) techniques used during the treatment. The written reports were analyzed and classified according to the frequency of the concepts and points presented, and the most prominent ones were reported. The analysis of the immediate and delayed post-test data revealed that receiving C-R tasks significantly improved the recall of collocations among EFL learners. The experimental group, which received C-R tasks, performed better than the control group in the posttest. The study found that learners’ retention of collocations is not affected by time, therefore C-R task practices enable retrieval during comprehension and retention. The findings can help learners and practitioners develop appropriate learning behaviors.
Global existence of non-Newtonian incompressible fluid in half space with nonhomogeneous initial-boundary data
Authors: Chang Tongkeun , Jin Bum Ja 
Published: November 2023

Abstract
In this study, we investigate the global existence of weak solution of non-Newtonian incompressible fluid governed by \eqref{maineq2}. When $u_0 \in \dot B^{\alpha-\frac{2}{p}}_{p,q}({\mathbb R}^{n}_+) \, \cap \,\dot B^{ 1 - \frac4{n+2}}_{\frac{n+2}2,\frac{n+2}2}({\mathbb R}^{n}_+) \,\cap \, \dot B^{ 1 +\frac{n}p}_{p,1} (\R_+)$ is given, we will find the weak solution for the equations \eqref{maineq2} in the function space $C_b ([ 0, \infty; \dot B^{\alpha -\frac2p}_{p,q} ({\mathbb R}^n_+))$, $ n+2 < p < \infty, \,\, 1 \leq q \leq \infty, \,\, 1 + \frac{n+2}p < \alpha < 2$. To show it, we will show the exisence of weak solution in the anisotropic Besov spaces $\dot B^{\alpha, \frac{\alpha}2}_{p,q} (\R_+ \times (0, \infty))$ (see Theorem \ref{thm-navier}) and we will show the embedding $\dot B^{\alpha, \frac{\alpha}2}_{p,q} (\R_+ \times (0, \infty) \subset C_b ([ 0, \infty; \dot B^{\alpha -\frac2p}_{p,q} ({\mathbb R}^n_+))$ (see Lemma \ref{lemma1208}). For the global existence of solution, we assume that the extra stress tensor $S$ is represented by $S({\mathbb A}) = {\mathbb F} ( {\mathbb A}) {\mathbb A}$, where ${\mathbb F}(0) $ is uniformly elliptic matrix and
\begin{align*}
|\big( {\mathbb F}({\mathbb A}) -{\mathbb F}(0) \big) {\mathbb A} - \big( {\mathbb F}({\mathbb B})- {\mathbb F}(0) \big){\mathbb B}| \leq o(\max ( |{\mathbb A}|, |{\mathbb B}|) ) |{\mathbb A} -{\mathbb B}| \quad \mbox{at zero}.
\end{align*}
Note that $S_1$, $S_2$ and $S_3$ introduced in \eqref{0207-1} satisfy our assumption.
Fog Forecast Model based on Machine Learning
Authors: Almeida Manoel Valdonel , França Gutemberg Borges , de Almeida Vinícius Albuquerque , Bonnet Suzanna Maria 
Published: November 2023

Abstract
This study introduces an innovative approach for fog forecasting based on Machine Learning (ML) algorithms. It involved utilizing eighteen years of surface and sounding meteorological data from Guarulhos International Airport and nearby Marte Airfield for training and testing ML models. Multiple categorical algorithms were trained and evaluated, with the top three models selected for further investigation. The results of the study highlight that the best-performing model, which is based on the Random Forest algorithm, can provide reasonably accurate predictions for the occurrence of fog. Specifically, it forecasts fog occurrence within a time window from 03 to 11 UTC with a reasonable degree of accuracy (Proportion Correct = 0.90 ± 0.03, Probability of detection = 0.96 ± 0.03, False Alarm Rate = 0.33 ± 0.01, Critical Success Index = 0.65 ± 0.02, and Bias = 1.43 ± 0.05). Additionally, the method indicates the most likely time for the onset and dissipation of fog events based on historical data. This research offers valuable insights into improving fog forecasting at the Guarulhos International Airport and demonstrates the potential of ML algorithms in enhancing predictive accuracy for weather-related events.
I’ve really struggled but it does not seem to work: Adolescents’ experiences of living with ADHD – a thematic analysis
Authors: Zetterqvist Vendela , Öster Caisa , Oremark Anna , Myllys Lotta , Meyer Jenny , Ramklint Mia , Isaksson Johan 
Published: November 2023

Abstract
In Attention-deficit/hyperactivity disorder (ADHD) the transition from childhood to adolescence encompass changes in symptom manifestation and related problems. Given the potential negative impact of ADHD on adolescents, and the increased risk for dropping out from treatment, there is a need to understand more about how adolescents experience their condition. The aim of this study was to explore adolescents’ perceptions of how it is to live with ADHD. Twenty adolescents (15–17 years old, 12 girls) diagnosed with ADHD who had completed a skills training group were interviewed. Data was analysed using thematic analysis. Four themes emerged: I find it hard to regulate what I take in and what comes out, I’ve really struggled but it does not seem to work, It impacts my vitality and my relationships, and I can be successful and things are getting better. The findings are discussed in terms of self-regulation, emotional impact, emotional dysregulation and loss of control versus empowerment.
Red cabbage extract contained sodium alginate/poly (vinyl alcohol) nanofibers as pH-responsive food packaging
Authors: Banadkooki Maryam Zare , Ziabakhsh Zahra Sadat , Sohrabi Amin , Khatibi Alireza , Taheri Alireza , Tehrani Mohsen Ebrahim , Reyhanipour Hamed Sourian , Mohammadi Fateme , Zahedi Payam 
Published: November 2023

Abstract
Red cabbage extract is a natural pH indicator and its use in polysaccharides is applicable to provide smart food packaging. In this study, we investigated the performance of sodium alginate (SA)/poly (vinyl alcohol) (PVA) nanofibers containing red cabbage extract (RCE) prepared by electrospinning method. The optimum volume ratio of SA: PVA (60:40) and the addition of RCE [2% (w/v)] to the polymeric solution were determined based on morphological uniformity and minimal average diameter of the nanofibers around 212.1 nm, and 217.2 nm, respectively. The presence of RCE in the SA: PVA nanofibrous sample was confirmed in accordance with appearing stretching carbon double bond at 1648 cm-1 and UV absorption of 310 nm. Moreover, RCE insertion in the SA: PVA (60: 40) blend nanofibers exhibited the increase of surface hydrophobicity a few and significant change in the crystallinity of the polymers. Eventually, the pH responsibility of the RCE contained SA: PVA nanofibers was evaluated via color alteration against different pH values (2–11). The obtained results revealed that the pH ascending led to a severe color change from light red to purple and then green. These findings showed that the recommended sample has high potential in smart food packaging application.
Anticancerous effect of bioactive compounds derived from the aqueous extract of Seaweed Laurencia karachiana Bibi
Authors: surendran vijayalekshmi , RENUGA F. BRISCA 
Published: November 2023

Abstract
Cancer is one of the major non-communicable disease affecting 18 million patients worldwide. It is reported to be the second most lethal disease in the world. The development of anticancer drugs using natural products obtained from marine organisms has been proposed as an alternative approach. Natural origins are the main origins for approved drugs in the treatment of cancer, occupying almost 60%. In this context, it is significant to develop natural products in cancer treatment. Seaweeds have bioactive compounds that show cytotoxicity in various cancer cell lines. Therefore, the present investigation undertakes to explore the anticancer activity of Laurencia karachiana Bibi. The A549 (Human lung adenocarcinoma cell line) and L929 (Mouse embryo fibroblast cell line) are purchased from NCCS, Pune, India. MTT assay were conducted to find out the antioxidant and anti-cancerous activity. The aqueous extract of L. karachiana shows a concentration dependent anti-oxidant activity and is cytotoxic in nature on Human lung cancer (A549) cells with IC50 value of 56.85 µg/ml and non-cytotoxic in nature on Mouse embryo fibroblast (L929) cells with IC50 value of 219.05 µg/ml. The MTT assay results suggest that the given test compound exhibit cytotoxic and anti-cancer activity against human lung cancer cells without affecting any toxic potency on Normal mouse fibroblast cells.