bluuebunny/crossref_metadata_2025_split huggingface dataset:
Media Papan Edukatif Main Anak (PEMA) untuk Meningkatkan Pra Membaca Anak Usia 5-6 Tahun
Authors: Amelia Zahrina , Rahmadani Anisa 
Published: November 2023

Kemampuan pra membaca anak usia dini menjadi perhatian utama para pendidik. Pemberian stimulus kemampuan pra membaca banyak ditemukan terkait dengan keterampilan akademik dan bahasa anak kelak. Tujuan penelitian ini adalah mendapatkan gambaran analisis dan masukan guna mengembangkan media Papan Edukatif Main Anak (PEMA) sebagai upaya meningkatkan kemampuan pra-membaca pada anak usia 5-6 tahun. Metode penelitian yang digunakan dalam penelitian ini adalah jenis penelitian pengembangan (Research And Development/RD) dengan menggunakan model ADDIE terhadap 10 anak (80% perempuan) tingkat Taman Kanak-Kanak. Pengumpulan data dilakukan melalui studi literatur, validasi pakar, pengamatan dan behavioral checklist. Penelitian dilakukan dengan siklus model ADDIE yang mencakup : analisis, desain, pengembangan, implementasi dan evaluasi. Hasil pengembangan media PEMA menunjukkan bahwa materi pada media PEMA sudah sesuai dengan indikator kemampuan pra-membaca anak. Evaluasi terhadap media yaitu penambahan fitur interaktif serta visual materi yang lebih menarik dan berwarna.
Efektifitas Penggunaan Smartphone oleh Orang Tua dalam Membantu Pembelajaran Anak Usia Dini
Authors: Budiarti Erna 
Published: November 2023

Era digital saat ini telah mengubah seluruh tatanan kehidupan umat manusia, dari persoalan ekonomi hingga persoalan pendidikan. Penggunaan smartphone seakan telah menjadi bagian dari kebutuhan hidup masyarakat termasuk orang tua Anak Usia Dini. Dalam pendidikan anak akan cenderung meniru apa yang sering dilakukan oleh orang tuanya. Penggunaan smartphone oleh orang tua juga akan ditiru oleh anak anak, maka kecenderungan orang tua menggunakan smartphone juga dapat menjadi alat edukatif dalam membantu pembelajaran anak. Penelitian ini dilakukan untuk dapat melihat bagaimana orang tua memanfaatkan Smartphone dan efektifitasnya dalam membantu pembelajaran anak. Penelitian ini menggunakan jenis penelitian deskriptif kualitatif dengan terhadap orang tua Anak Usia Dini serta guru Anak Usia Dini yang tersebar di wilayah DKI Jakarta dan Jawa Barat serta beberapa daerah lainya di Indonesia yang dipilih secara acak. Hasil penelitian menunjukkan bahwa orang tua hanya menggunakan smartphone untuk keperluan pribadinya seperti berkomunikasi, bersosial media beriklan dan lain sebagainya, dan bahkan beberapa temuuan menunjukkan orang tua tidak mengetahui adanya aplikasi-aplikasi pembelajaran anak yang dapat membantu pembelajaran anak, orang tua anak hanya memanfaatkan satu aplikasi yaitu watshapp untuk menerima dan mengirimkan tugas anak-anaknya dari guru di sekolah.
Bilateral infraoptic origin of the anterior cerebral artery: illustrative case
Authors: Majmundar Neil , Quillin Joseph , Liu James K , Agarwalla Pankaj K 
Published: November 2023

BACKGROUND
A bilateral infraoptic origin of the anterior cerebral arteries (ACAs) is a rare anatomical variant that can be encountered during anterior skull base surgery. The ACAs arise from the internal carotid artery (ICA) at the level of the ophthalmic artery and course medially, traveling inferior to the ipsilateral optic nerves. Herein, the authors discuss the different configurations of the anatomical variant, its prevalence, and hypotheses leading to the variable configuration of this anomaly.

OBSERVATIONS
A 67-year-old woman presented with worsening dizziness over a week-long period and was found to have a large left sphenocavernous meningioma with optic, cavernous, and suprasellar extension. The tumor incorporated the left supraclinoid ICA and its branches. She underwent a left modified orbitozygomatic craniotomy for tumor resection. Early identification of the aberrant ACA anatomy was crucial in avoiding vascular injury.

LESSONS
While this variant is typically encountered during the treatment of vascular pathologies—namely, intracranial aneurysms—its existence should be kept in mind during the treatment of any anterior skull base pathology. Failure to account for the presence of this variant may lead to potential intraoperative complications.
Pengaruh Model Pembelajaran Kooperatif Tipe STAD Berbantuan Media Puzzle Terhadap Hasil Belajar Siswa Pada Pembelajaran Matematika Kelas 2 SD
Authors: Inas Fauziah Farda  , Nurrohmatul Amaliyah  
Published: November 2023

Classical lecture and question and answer methods are mostly chosen by teachers. As a result, students are less enthusiastic in following the lesson and the classroom atmosphere looks inactive. To improve students' learning outcomes, a learning innovation based on the STAD type cooperative learning model is needed. The purpose of this study was to analyze the effect of the STAD type cooperative learning model assisted by Puzzle Media on student learning outcomes in Grade 2 mathematics learning. This research uses quantitative research using experimental methods. The design form used in this research is true experimental. In this study the research subjects were divided into two groups, namely the control class group and the experimental class group. Of the two classes, the control class and the experimental class were determined, class II A was selected as the experimental class and class II B was selected as the control class. The technique used in collecting data in this study used a test instrument. The results of this study are the average of the experimental class which is 70, 17 and the control class is 57, 00, from these results there is a significant difference in learning outcomes which indicates the effect of the STAD type cooperative learning model as an effective learning innovation that can be applied so that learning is fun for students.
Estratégia, conceito e produtividade de leite e queijo caprino: Uma revisão bibliográfica
Authors: Oriente Suelma Ferreira do , Silva Pedro Ivo Soares e , Ramos Nayara Jessica da Silva , Santos Rebeca Morais Silva , Gusmão Thaisa Abrantes Souza , Gusmão Rennan Pereira de , Pasquali Matheus Augusto de Bittencourt 
Published: November 2023

O leite caprino tem grande importância socioeconômica na produção de alimentos no Nordeste brasileiro, sendo a pecuária caprina uma das principais atividades realizadas na região Semiárida. É importante ressaltar que, o Semiárido Paraibano se caracteriza por apresentar condições ambientais de terras áridas e de baixa pluviosidade, onde os caprinos têm no bioma Caatinga sua principal fonte alimentar, que, somado ao reconhecido valor nutricional do leite caprino, o faz assumir papel na alimentação complementar das crianças dessa região. Sendo o leite caprino um alimento de alta digestibilidade e de elevado valor nutricional, o consumo deste produto vem aumentando devido à procura por derivados lácteos (com ênfase aos queijos) e aos problemas de alergia ao leite bovino. Logo, o estudo tem como objetivo conceituar o leite e queijo caprinos em termos de inovação, tendências, produtividade e impacto na saúde através de uma revisão bibliográfica narrativa. A abordagem metodológica permitiu o uso de estudos experimentais e não experimentais para ter uma compreensão completa sobre a temática proposta. O leite caprino apresenta uma composição rica em proteínas, vitaminas, com destaque para a vitamina A, gordura, extrato seco, carboidratos e sais minerais, os quais são essenciais aos seres humanos. Portanto, torna-se de interesse o aprofundamento de estudos sobre as potencialidades funcionais dos compostos presentes no queijo caprino, possibilitando alternativas de processamento da matéria-prima, o leite caprino.
Estilo e qualidade de vida dos estudantes de Medicina do estado de Sergipe
Authors: Oliveira Lucas Augusto Reis Pereira de , Debbo Alejandra , Nascimento Leila Maria Lemos 
Published: November 2023

O estilo de vida é caracterizado por padrões de comportamento identificáveis que podem ter um efeito profundo na saúde da população e está relacionado com diversos aspectos que refletem as atitudes, os valores e as oportunidades na vida das pessoas Sendo assim, faz necessário o desenvolvimento de hábitos de vida saudáveis, com a prática de atividades físicas e uma boa alimentação, atreladas aos bons relacionamentos sociais, prática de sexo com segurança, o não consumo de álcool e drogas, além do controle do estresse e ansiedade. Nos alunos universitários, particularmente os que cursam Medicina, a carga horária intensa, a diminuição das atividades de lazer e do convívio social, os conteúdos extensos, somados ao frequente contato com doenças e morte, favorecem a estes um comprometimento na qualidade de vida. O presenta artigo trata-se de um estudo transversal e quantitativo com coleta de dados por meio de formulário. Feito com acadêmicos de medicina estado de Sergipe que tem como finalidade, portanto, avaliar o impacto na qualidade de vida e saúde dos estudantes de medicina durante sua graduação, usando-se um questionário autoaplicável chamado “Estilo de Vida Fantástico”, atrelado a variáveis como idade, período do estudante, sexo, diagnóstico pregresso psiquiátrico e uso de drogas psicoativas.
Аграрна освіта у сільськогосподарських навчальних закладах Херсонської губернії другої половини 19 – початку 20 ст.
Authors: Trygub Oleksandr 
Published: November 2023

Метою статті є окреслення загальних тенденцій становлення аграрної освіти другої половини 19 – початку 20 ст. у межах Херсонської губернії; визначення кола ключових сільськогосподарських навчальних закладів, їх виникнення та розвиток у зазначений період; характеристика соціальної та вікової складової контингенту учнів тощо.
Наукова новизна: узагальнено відомості з питання становлення аграрної освіти у Херсонській губернії у дорадянський час; сформовано соціальну картину учнів, яка свідчить про переважно селянську спрямованість аграрної освіти.
Висновки. З початком реалізації Селянської реформи все актуальнішим поставало питання підвищення ефективності сільського виробництва, що напряму було пов’язано із поширенням агрономічних знань і підготовкою професійних агрономів.
В останній чверті 19 ст. увага прогресивних кіл суспільства – земських органів, громадських організацій і приватних осіб до розвитку нижчої сільської профтехшколи неухильно зростала й об’єднувалися їхні зусилля щодо створення навчальних закладів. У Херсонській губернії ключову роль у відкритті навчальних аграрних закладів і подальшому їхньому розвиткові відігравали земства, громадські об’єднання та приватна ініціатива. Держава, у розрізі підтримки й розвитку аграрної освіти, виступала здебільшого одним із інвесторів, регулятором і контролюючим органом, виконуючи в їх започаткуванні другорядну роль.
Не дивлячись на постійну нестачу коштів, слабку навчально-методичну, дидактичну й організаційно-правову базу аграрні навчальні заклади зробили суттєвий внесок у становлення системи підготовки кваліфікованого кадрового потенціалу сільського господарства регіону. Окрім того, нововідкриті заклади зробили певний внесок до наукових пошуків у в аграрній сфері, допомагали в організації зразкових полів, упроваджували нові сільськогосподарські культури, закладали нові сади, виноградники тощо.
Несли сільськогосподарські навчальні заклади і просвітницьку роль. На початку 20 ст. традиційним стало проведення на їх базі різного роду курсів (для агрономів, вчителів, селянства тощо) з викладанням знань із сільського господарства; а Російське товариство з поширення освіти між євреями відряджало учителів єврейських шкіл до Новополтавки «для ознайомлення з постановкою навчання природознавству» і т.д.
Фінансування. Стаття підготовлена за результатами фундаментального дослідження «Соціокультурний простір України другої половини ХІХ – першої третини ХХ ст.: селянський світ» (номер державної реєстрації: 0123U101600) за підтримки Національного фонду досліджень України.
Graphene quantum dots promote migration and differentiation of periodontal ligament stem cells
Authors: Liang Yan , Gao Wanshan , Deng Sicheng , Wu Dongyan , Jiang Yiling , Zhang Yishan , Qiu Rongmin 
Published: November 2023

Graphene and its derivatives have attracted much attention as nanomaterials in bone tissue engineering because of their remarkable ability to induce cell osteogenic differentiation. However, graphene quantum dots (GQDs), as graphene derivatives, little is known about their osteodifferentiation- and osteoinduction-promoting capabilities, especially in the restoration of bone defect caused by periodontitis. Therefore, there is a growing need to investigate the effect of GQDs on periodontal ligament stem cells (PDLSCs). Here, we postulated that GQDs are a promising biocompatible nanomaterial that facilitated the migration and differentiation of PDLSCs, and use laboratory methods like CCK-8, transwell experiments, qRT-PCR, Alizarin red staining and immunofluorescence staining to evaluate. Our experiments confirmed that GQDs did not inhibit cell viability, with most cells remaining viable even at GQDs concentrations of up to 30 μg mL-1. Moreover, GQDs were found to significantly enhance PDLSC migration, with the peak effect observed at concentrations of 5 and 10 μg mL-1. Furthermore, GQDs accelerated osteoblastic differentiation in PDLSCs and induced the mineralization of calcium nodules. Additionally, GQDs were shown to promote fibroblast differentiation in PDLSCs compared to the control group. Thus, GQDs not only possessed low cytotoxicity and good biocompatibility, but also displayed the beneficial capability to migration and differentiation of PDLSCs, which indicated GQDs might be a potential nanomaterial for bone regeneration.
When do tripdoublet states fluoresce? A theoretical study of copper(II) porphyrin
Authors: Wang Xingwen , Wu Chenyu , Wang Zikuan , Liu Wenjian 
Published: November 2023

Open-shell molecules rarely fluoresce, due to their typically faster non-radiative relaxation rates compared to closed-shell ones. Even rarer is the fluorescence from states that have two more unpaired electrons than the open-shell ground state, since they involve excitations from closed-shell orbitals to vacant-shell orbitals, which are typically higher in energy compared to excitations from or out of open-shell orbitals. States that are dominated by the former type of excitations are known as tripdoublet states when they can be described as a triplet excitation antiferromagnetically coupled to a doublet state, and their description by unrestricted single-reference methods (e.g., U-TDDFT) is notoriously inaccurate due to large spin contamination. In this work, we applied our spin-adapted TDDFT method, X-TDDFT, and the efficient and accurate static-dynamic-static second order perturbation theory (SDSPT2), to the study of the excited states as well as their relaxation pathways of copper(II) porphyrin; previous experimental works suggested that the photoluminescence of some substituted copper(II) porphyrins originate from a tripdoublet state, formed by a triplet ligand π → π* excitation antiferromagnetically coupled with the unpaired d electron. Our results demonstrated favorable agreement between the X-TDDFT, SDSPT2 and experimental excitation energies, and revealed noticeable improvements of X-TDDFT compared to U-TDDFT, not only for vertical excitation energies but also for adiabatic energy differences. These suggest that X-TDDFT is a reliable tool for the study of tripdoublet state fluorescence. Intriguingly, we showed that the aforementioned tripdoublet state is only slightly above the lowest doublet excited state and lies only slightly higher than the lowest quartet state, which suggests that the tripdoublet of copper(II) porphyrin is long-lived enough to fluoresce due to a lack of efficient non-radiative relaxation pathways; an explanation for this unusual state ordering is given. Indeed, thermal vibration correlation function (TVCF)-based calculations of internal conversion, intersystem crossing, and radiative transition rates confirm that copper(II) porphyrin emits thermally activated delayed fluorescence (TADF) and a small amount of phosphorescence at low temperature (83 K), in accordance with experiment. The present contribution is concluded by a few possible approaches of designing new molecules that fluoresce from tripdoublet states.
Hemoglobin albumin lymphocyte and platelet score and all-cause mortality in coronary heart disease: a retrospective cohort study of NHANES database
Authors: Zheng Yang , Huang Yubing , Li Haitao 
Published: November 2023

AimAnemia, inflammatory status, and malnutrition are all important factors in the prognosis of cardiovascular disease (CVD), and their interactions are also noteworthy. A recent scoring system, the hemoglobin albumin lymphocyte and platelet (HALP) score, combining multi-dimensional metrics, has been used in the prognoses of many diseases except coronary heart disease (CHD). Herein, this study aims to explore the association between HALP score and all-cause mortality in patients with CHD.MethodsDemographic and clinical data of adult patients with CHD were extracted from the National Health and Nutrition Examination Surveys (NHANES) database from 2003 to 2018 in this retrospective cohort study. Weighted univariate and multivariate COX proportional hazard models were used for covariates screening and exploration of the association between HALP score and all-cause mortality. The evaluation indexes were hazard ratios (ORs) and 95% confidence intervals (CIs). Kaplan-Meier (KM) curve and the receiver operator characteristic (ROC) curve were used to assess the predictive performance of HALP on CHD prognosis. In addition, subgroup analyses of age and congestive heart failure (CHF) were also performed.ResultsAmong the eligible patients, 657 died of all-cause mortality. After adjusting for the covariates including age, education level, PIR, marital status, smoking, physical activity, total energy intake, CHF, stroke, hypertension, DM, CKD, cancer or malignancy, monocyte, drug for CVD, treatment for anemia, anticoagulants drug, and adrenal cortical steroids, we found that HALP score was negatively associated with the risk of all-cause mortality [HR = 0.83, 95% CI: (0.74–0.93)]. Compared with patients with high HALP scores, those who had lower HALP scores seemed to have a higher risk of all-cause mortality (all P &lt; 0.05). HALP score has a potential predictive value on CHD prognosis with an area under the curve (AUC) of 0.61. Furthermore, in patients aged &lt;65 years, with or without CHF, a lower HALP score was also associated with a higher risk of all-cause mortality (all P &lt; 0.05).ConclusionsHALP score has a potential predictive value on CHD prognosis; however, the causal association between HALP score and mortality in patients with CHD needs further exploration.
Lower ventricular and atrial strain in patients who recovered from COVID-19 assessed by cardiovascular magnetic resonance feature tracking
Authors: Mojica-Pisciotti Mary Luz , Panovský Roman , Holeček Tomáš , Opatřil Lukáš , Feitová Věra 
Published: November 2023

IntroductionOne of the most common complications of coronavirus disease 2019 (COVID-19) is myocardial injury, and although its cause is unclear, it can alter the heart's contractility. This study aimed to characterize the ventricular and atrial strain in patients who recovered from COVID-19 using cardiovascular magnetic resonance feature-tracking (CMR-FT).MethodsIn this single-center study, we assessed left ventricle (LV) and right ventricular (RV) global circumferential strain (GCS), global longitudinal strain (GLS), global radial strain (GRS), left atrial (LA) and right atrial (RA) longitudinal strain (LS) parameters by CMR-FT. The student's t-test and Wilcoxon rank-sum test were used to compare the variables.ResultsWe compared seventy-two patients who recovered from COVID-19 (49 ± 16 years) to fifty-four controls (49 ± 12 years, p = 0.752). The patients received a CMR examination 48 (34 to 165) days after the COVID-19 diagnosis. 28% had LGE. Both groups had normal LV systolic function. Strain parameters were significantly lower in the COVID-19 survivors than in controls.DiscussionPatients who recovered from COVID-19 exhibited significantly lower strain in the left ventricle (through LVGCS, LVGLS, LVGRS), right ventricle (through RVGLS and RVGRS), left atrium (through LALS), and right atrium (through RALS) than controls.
Sustainable development goals in teacher education: comparing syllabi in a Japanese and a Slovenian university
Authors: Fiel’ardh Khalifatulloh , Torkar Gregor , Rožman Hana , Fujii Hiroki 
Published: November 2023

IntroductionThis research aims to explore the integration of Sustainable Development Goals (SDGs) within teacher education programs, focusing on the Faculty of Education at Okayama University, Japan and the University of Ljubljana, Slovenia.MethodsWe employed a qualitative content analysis of the syllabi (n = 2,079 from Okayama University; n = 504 from University of Ljubljana) and combined it with insights from semi-structured interviews.ResultsThe analysis illuminated a strong emphasis on Quality Education (SDG 4) in both institutions. However, certain SDGs, like Climate Action (SDG 13), were less represented, marking potential areas for enhancement. Differences were also identified in the distribution of SDGs-related content between compulsory and elective courses, indicating institutional priorities. Interview reflections emphasized the pivotal role of educators in realizing SDGs and highlighted the necessity of collaboration to achieve these global objectives.DiscussionThe insights from interviews and syllabi content analysis underscore the urgency to bridge the identified gaps in SDG coverage. Disparities in emphasis between the two Education for Sustainable Development (ESD)-committed universities were noted, suggesting the importance of fostering strategy exchange and partnerships across institutions.ConclusionEnhancing the alignment of teacher education programs with SDGs requires collective efforts. By addressing the gaps and promoting effective collaboration, these programs can achieve greater relevance and efficacy in promoting the SDGs.
Association of Cutibacterium acnes with human thyroid cancer
Authors: Trivedi Vaishakhi , Noronha Vanita , Sreekanthreddy Peddagangannagari , Desai Sanket , Poojary Disha , Varghese Linu , Gowda Pooja , Butle Ashwin , Mishra Rohit , Bal Munita , Mittal Neha , Rane Swapnil , Kane Shubhada , Basu Sandip , Patil Vijay , Menon Nandini , Singh Ajay Kumar , Chaturvedi Pankaj , Chandrani Pratik , Choughule Anuradha , Veldore Vidya , Prabhash Kumar , Dutt Amit 
Published: November 2023

IntroductionThe diverse subtypes of thyroid carcinoma have distinct clinical outcomes despite a comparable spectrum of underlying genetic alterations. Beyond genetic alterations, sparse efforts have been made to characterize the microbes associated with thyroid cancer. In this study, we examine the microbial profile of thyroid cancer.MethodsWe sequenced the whole transcriptome of 70 thyroid cancers (40 papillary and 30 anaplastic). Using Infectious Pathogen Detector IPD 2.0, we analysed the relative abundance of 1060 microbes across 70 tumours from patients with thyroid cancer against 118 tumour samples from patients with breast, cervical, colorectal, and tongue cancer.ResultsOur analysis reveals a significant prevalence of Cutibacterium acnes in 58.6% thyroid cancer samples compared to other cancer types (p=0.00038). Immune cell fraction analysis between thyroid cancer samples with high and low Cutibacterium loads identify enrichment of immunosuppressive cells, including Tregs (p=0.015), and other anti-inflammatory cytokines in the tumour microenvironment, suggesting an immune evasion/immunosuppression milieu is associated with the infection. A higher burden of Cutibacterium acnes was also found to be associated with poor survival defining a distinct sub-group of thyroid cancer.ConclusionCutibacterium acnes is associated with immune suppression and poor prognosis in a subpopulation of thyroid cancer. This study may help design novel therapeutic measures involving appropriate antibiotics to manage the disease better.