bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Stratification in People with Diabetes for Fasting During Ramadan:
Consensus from Arabic Association for the Study of Diabetes and
Metabolism
Authors: Shaltout Inass , Abdelwahab Amr Mahmoud , El Meligi Amr , Hammad Hany , Abdelghaffar Shereen , Elbahry Atef , Taha Nasser , Elsaid Nehal Hamdy , Gad Amr , Hammouda Laila , Abdelmaboud Shaymaa , Soliman Amin Roshdy 
Published: October 2023

Background:
Current international guidelines recommend a pre-Ramadan risk assessment for people with diabetes (PwDM) who plan on fasting during the Holy month. However, a comprehensive risk assessment-based recommendation for the management of PwDM intending to fast is still controversial. Therefore, the Arabic Association for the Study of Diabetes
and Metabolism (AASD) developed this consensus to provide further insights into risk stratification in PwDM intending to fast during Ramadan.

Methods:
The present consensus was based on the three-step modified Delphi method. The
modified Delphi method is based on a series of voting rounds and in-between meetings of the
expert panel to reach agreements on the statements that did not reach the consensus level during
voting. The panel group comprised professors and consultants in endocrinology (both adult and
pediatric). Other members included experts in the fields of cardiovascular medicine, nephrology,
ophthalmology, and vascular surgery, affiliated with academic institutions in Egypt.

Result:
In PwDM who intend to fast during Ramadan, risk stratification is crucial to optimize
patient outcomes and prevent serious complications. The present consensus provides risk assessment of those living with diabetes according to several factors, including the type of diabetes, presence, and severity of complications, number of fasting hours, and other socioeconomic
factors. According to their risk factors, patients were classified into four categories (very high,
high, moderate, and low risk).

Conclusion:
Future research is warranted due to the controversial literature regarding the impact
of fasting on certain comorbidities.
The Functional Role of microRNAs and mRNAs in Diabetic Kidney
Disease: A Review
Authors: Rai Bhuvnesh , Srivastava Jyotika , Saxena Pragati 
Published: October 2023

Abstract:
Diabetes is a group of diseases marked by poor control of blood glucose levels. Diabetes
mellitus (DM) occurs when pancreatic cells fail to make insulin, which is required to keep
blood glucose levels stable, disorders, and so on. High glucose levels in the blood induce diabetic
effects, which can cause catastrophic damage to bodily organs such as the eyes and lower extremities.
Diabetes is classified into many forms, one of which is controlled by hyperglycemia or
Diabetic Kidney Disease (DKD), and another that is not controlled by hyperglycemia (nondiabetic
kidney disease or NDKD) and is caused by other factors such as hypertension, hereditary.
DKD is associated with diabetic nephropathy (DN), a leading cause of chronic kidney disease
(CKD) and end-stage renal failure. The disease is characterized by glomerular basement
membrane thickening, glomerular sclerosis, and mesangial expansion, resulting in a progressive
decrease in glomerular filtration rate, glomerular hypertension, and renal failure or nephrotic
syndrome. It is also represented by some microvascular complications such as nerve ischemia
produced by intracellular metabolic changes, microvascular illness, and the direct impact of excessive
blood glucose on neuronal activity. Therefore, DKD-induced nephrotic failure is worse
than NDKD.

:
MicroRNAs (miRNAs) are important in the development and progression of several diseases, including
diabetic kidney disease (DKD). These dysregulated miRNAs can impact various cellular
processes, including inflammation, fibrosis, oxidative stress, and apoptosis, all of which are implicated
during DKD. MiRNAs can alter the course of DKD by targeting several essential mechanisms.
Understanding the miRNAs implicated in DKD and their involvement in disease development
might lead to identifying possible therapeutic targets for DKD prevention and therapy.
Therefore, this review focuses specifically on DKD-associated DN, as well as how in-silico approaches
may aid in improving the management of the disease.
FDM 3D printing application for making plate pattern on sand casting
Authors: Royan Muhammad , Soemowidagdo Arianto Leman , Sasongko Beni Tri , Pradana Deny Aji 
Published: October 2023

Pattern making in sand casting requires high-level skilled workers since accuracy is the most important concern in producing good quality products. Therefore, conventional pattern-making becomes a major obstacle in developing new products, especially for complicated products as it takes over 70% of the total time in production of the foundry process. This study offers an alternative method in pattern making utilizing 3D technology with the Fuse Deposition Material (FDM) method. It consisted of three steps: planning, production, and evaluation. An intake manifold is an example product that was designed by using Computer Aided Design (CAD) and then imported to a slicer application to obtain the G codes. After the design was printed by using filament of PLA+, it was assembled to create the plate pattern that then was used to produce the intake manifold through casting. The study result shows that the FDM method of the 3D printing technology is feasible for pattern making on sand casting. Deviation and shrinkage of the casting product were still within tolerance. The largest shrinkage is 0.453 mm (1.258%).
Support for Chronic Pain Management for Breast Cancer Survivors Through Novel Digital Health Ecosystems: Pilot Usability Study of the PainRELife Mobile App
Authors: Masiero Marianna , Filipponi Chiara , Fragale Elisa , Pizzoli Silvia Francesca Maria , Munzone Elisabetta , Milani Alessandra , Guido Luca , Guardamagna Vittorio , Marceglia Sara , Prandin Roberto , Prenassi Marco , Caruso Annamaria , Manzelli Vania , Savino Chiara , Conti Costanza , Rizzi Federica , Casalino Alice , Candiani Giulia , Memini Francesca , Chiveri Luca , Vitali Andrea Luigi , Corbo Massimo , Grasso Roberto , Didier Florence , Ferrucci Roberta , Pravettoni Gabriella 
Published: October 2023

Background
Chronic pain is one of the most common and critical long-term effects of breast cancer. Digital health technologies enhance the management of chronic pain by monitoring physical and psychological health status and supporting pain self-management and patient treatment decisions throughout the clinical pathway.

Objective
This pilot study aims to evaluate patients’ experiences, including usability, with a novel digital integrated health ecosystem for chronic pain named PainRELife. The sample included patients with breast cancer during survivorship. The PainRELife ecosystem comprises a cloud technology platform interconnected with electronic health records and patients' devices to gather integrated health care data.

Methods
We enrolled 25 patients with breast cancer (mean age 47.12 years) experiencing pain. They were instructed to use the PainRELife mobile app for 3 months consecutively. The Mobile Application Rating Scale (MARS) was used to evaluate usability. Furthermore, pain self-efficacy and participation in treatment decisions were evaluated. The study received ethical approval (R1597/21-IEO 1701) from the Ethical Committee of the European Institute of Oncology.

Results
The MARS subscale scores were medium to high (range: 3.31-4.18), and the total app quality score was 3.90. Patients with breast cancer reported reduced pain intensity at 3 months, from a mean of 5 at T0 to a mean of 3.72 at T2 (P=.04). The total number of times the app was accessed was positively correlated with pain intensity at 3 months (P=.03). The engagement (P=.03), information (P=.04), and subjective quality (P=.007) subscales were positively correlated with shared decision-making. Furthermore, participants with a lower pain self-efficacy at T2 (mean 40.83) used the mobile app more than participants with a higher pain self-efficacy (mean 48.46; P=.057).

Conclusions
The data collected in this study highlight that digital health technologies, when developed using a patient-driven approach, might be valuable tools for increasing participation in clinical care by patients with breast cancer, permitting them to achieve a series of key clinical outcomes and improving quality of life. Digital integrated health ecosystems might be important tools for improving ongoing monitoring of physical status, psychological burden, and socioeconomic issues during the cancer survivorship trajectory.

International Registered Report Identifier (IRRID)
RR2-10.2196/41216
Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice
Authors: Beretta Martina , Dai Yumin , Olzomer Ellen M. , Vancuylenburg Calum S. , Santiago-Rivera José A. , Philp Ashleigh M. , Hargett Stefan R. , Li Keyong , Shah Divya P. , Chen Sing-Young , Alexopoulos Stephanie J. , Li Catherine , Harris Thurl E. , Lee Brendan , Wathier Michel , Cermak Jennifer M. , Tucker Simon P. , Turner Nigel , Bayliss Douglas A. , Philp Andrew , Byrne Frances L. , Santos Webster L. , Hoehn Kyle L. 
Published: October 2023

Excess body fat is a risk factor for metabolic diseases and is a leading preventable cause of morbidity and mortality worldwide. There is a strong need to find new treatments that decrease the burden of obesity and lower the risk of obesity-related comorbidities, including cardiovascular disease and type 2 diabetes. Pharmacologic mitochondrial uncouplers represent a potential treatment for obesity through their ability to increase nutrient oxidation. Herein, we report the in vitro and in vivo characterization of compound SHD865, the first compound to be studied in vivo in a newly discovered class of imidazolopyrazine mitochondrial uncouplers. SHD865 is a derivative of the furazanopyrazine uncoupler BAM15. SHD865 is a milder mitochondrial uncoupler than BAM15 that results in a lower maximal respiration rate. In a mouse model of diet-induced adiposity, 6-week treatment with SHD865 completely restored normal body composition and glucose tolerance to levels like those of chow-fed controls, without altering food intake. SHD865 treatment also corrected liver steatosis and plasma hyperlipidemia to normal levels comparable with chow-fed controls. SHD865 has maximal oral bioavailability in rats and slow clearance in human microsomes and hepatocytes. Collectively, these data identify the potential of imidazolopyrazine mitochondrial uncouplers as drug candidates for the treatment of obesity-related disorders.

Article Highlights
Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity
Authors: Tricò Domenico , Chiriacò Martina , Nouws Jessica , Vash-Margita Alla , Kursawe Romy , Tarabra Elena , Galderisi Alfonso , Natali Andrea , Giannini Cosimo , Hellerstein Marc , Ferrannini Ele , Caprio Sonia 
Published: October 2023

Excessive insulin secretion independent of insulin resistance, defined as primary hypersecretion, is associated with obesity and an unfavorable metabolic phenotype. We examined the characteristics of adipose tissue of youth with primary insulin hypersecretion and the longitudinal metabolic alterations influenced by the complex adipo-insular interplay. In a multiethnic cohort of adolescents with obesity but without diabetes, primary insulin hypersecretors had enhanced model-derived β-cell glucose sensitivity and rate sensitivity but worse glucose tolerance, despite similar demographics, adiposity, and insulin resistance measured by both oral glucose tolerance test and euglycemic-hyperinsulinemic clamp. Hypersecretors had greater intrahepatic and visceral fat depots at abdominal MRI, hypertrophic abdominal subcutaneous adipocytes, higher free fatty acid and leptin serum levels per fat mass, and faster in vivo lipid turnover assessed by a long-term 2H2O labeling protocol. At 2-year follow-up, hypersecretors had greater fat accrual and a threefold higher risk for abnormal glucose tolerance, while individuals with hypertrophic adipocytes or higher leptin levels showed enhanced β-cell glucose sensitivity. Primary insulin hypersecretion is associated with marked alterations in adipose tissue distribution, cellularity, and lipid dynamics, independent of whole-body adiposity and insulin resistance. Pathogenetic insight into the metabolic crosstalk between β-cell and adipocyte may help to identify individuals at risk for chronic hyperinsulinemia, body weight gain, and glucose intolerance.

Article Highlights
Efikasi Herbisida Parakuat terhadap Gulma pada Kebun Kelapa Sawit (Elaeis guineensis Jack.) Belum Menghasilkan (TBM)
Authors: Hidayat Pujisiswanto , Putri Athmarratu Wintani , Evizal Rusdi , Sriyani Nanik 
Published: October 2023

Pertumbuhan gulma pada kebun kelapa sawit (Elaeis guineensis Jacq.) dapat merugikan pertumbuhan tanaman sehingga perlu dilakukan pengendalian. Salah satu alternatif untuk mengendalikan gulma dengan menggunakan herbisida parakuat diklorida. Penelitian ini bertujuan untuk mengetahui efikasi herbisida parakuat diklorida terhadap gulma pada tanaman kelapa sawit. Penelitian dilaksanakan pada bulan September-November 2022 di Desa Sido Mukti, Kecamatan Natar, Kabupaten Lampung Selatan dan Laboratorium Ilmu Gulma Universitas Lampung. Penelitian menggunakan Rancangan Acak Kelompok (RAK) dengan 6 perlakuan dan 4 ulangan. Perlakuan yang ditetapkan yaitu Parakuat diklorida 276 g/l dosis 621 g/ha, Parakuat diklorida 276 g/l dosis 828 g/ha, Parakuat diklorida 276 g/l dosis 1.035 g/ha, Parakuat diklorida 276 g/l dosis 1.242 g/ha, penyiangan manual dan Kontrol (tanpa pengendalian gulma). Uji homogenitas ragam data dilakukan dengan uji Barlett, uji aditivitas dengan menggunakan uji Tukey. Jika syarat asumsi memenuhi, maka data dianalisis dengan sidik ragam dan untuk menguji perbedaan nilai tengah dilakukan dengan uji Beda Nyata Terkecil (BNT) pada taraf 5%. Hasil penelitian menunjukkan Herbisida parakuat diklorida pada dosis 621 g/ha – 1.242 g/ha efektif mengendalikan pertumbuhan gulma total, gulma golongan daun lebar, gulma dominan Praxelis clematidea, Borreria alata, dan Paspalum conjugatum. Sedangkan pada taraf dosis 828 g/ha – 1.242 g/ha efektif mengendalikan gulma golongan rumput, gulma dominan Digitaria ciliaris, dan Eleusine indica. Koefisien komunitas (C) pada 4 dan 8 minggu setelah aplikasi menunjukkan nilai < 75% yang menunjukkan perbedaan antar komunitas perlakuan. Aplikasi herbisida parakuat diklorida pada piringan tanaman kelapa sawit belum menghasilkan tidak menimbulkan keracunan pada tanaman kelapa sawit. Kata kunci: Fitotoksisitas, herbisida, parakuat diklorida, gulma, kelapa sawit
Efektivitas Priming pada Benih Jagung dalam Memperbaiki Perkecambahan pada Media Masam
Authors: Agustin Noly , Agustiansyah Agustiansyah , Timotiwu Paul Benyamin , Kamal Muhammad 
Published: October 2023

The high Aluminum content in Ultisol soil is one of the main problems in maize cultivation starting from the germination phase to plant growth. Priming treatment on seeds is believed to be able to improve germination in a less favorable environment. The study was conducted to determine the effect of priming on the germination of corn seeds germinated in acid media containing aluminum. The study was arranged in a Completely Randomized Design (CRD) which was repeated four times. There were 8 treatments in this study, namely control/without priming, water priming, KNO3 0.1%, and 0.5, PEG-6000 5% and 10%, GA3 50 ppm and 100 ppm. The data were analyzed for variance and continued with a 5% LSD test using the R Studio statistic program. The results showed that 50 ppm GA3 priming was the best treatment for increasing corn seed vigor based on the variables of time of radicle emergence, time of emergence of plumules, growth speed, growth synchronously, vigor index, root length, coleoptile length, wet weight of normal sprouts, and dry weight of normal sprouts. Keywords:priming, corn, germination
Analisa Kondisi Jalan Menggunakan Metode SDI (Surface Distress Index) di Ruas Jalan Sp. Aji – Sp. Lubuk Dalam, Kabupaten Ogan Komering Ulu Selatan
Authors: Kapitan Rama , Wardono Herry , Forda Nama Gigih 
Published: October 2023

Analisa kondisi jalan menggunakan metode SDI (Surface Distress Index) dilakukan di ruas jalan Sp. Aji – Sp. Lubuk Dalam Kabupaten Ogan Komering Ulu Selatan. Ruas ini merupakan ruas jalan kabupaten yang menghubungkan 7 kecamatan di Kabupaten Ogan Komering Ulu Selatan yang harus mendapatkan perhatian lebih melalui penanganan jalan. Penelitian ini bertujuan untuk menganalisis kondisi jalan, menganalisis jenis penanganan jalan. Data yang digunakan dalam penelitian adalah data primer dan data sekunder. Data primer didapatkan melalui survei kondisi jalan dengan pengukuran kerusakan jalan, sedangkan data sekunder didapatkan dari bidang bina marga Dinas PU-TR Kabupaten Ogan Komering Ulu Selatan yaitu, SK jalan Kabupaten Ogan Komering Ulu Selatan dan peta jalan Kabupaten Ogan Komering Ulu Selatan. Tahapan penelitian yaitu, identifikasi kerusakan jalan dengan melakukan pengukuran, rekapitulasi data dengan mengolah hasil survei, analisis data dengan metode SDI. Hasil penilaian untuk ruas Jl. Sp. Aji – Sp. Lubuk Dalam kondisi ringan 2,6 km dan kondisi rusak berat 7,2 km. Untuk jenis penanganan yang dilakukan Jl. Sp. Aji – Sp. Lubuk Dalam adalah rekonstruksi/ peningkatan jalan dan pemeliharaan berkala jalan/ rehabilitasi.
ANALISIS KEKUATAN STRUKTUR BANGUNAN GEDUNG SAMSAT RAJABASA
Authors: Sinia Ria Oktaviani , Widyawati Ratna , Sarkowi Muh 
Published: October 2023

Gedung Samsat Rajabasa Kota Bandar Lampung merupakan salah satu gedung pelayanan umum yang ada di Kota Bandar Lampung. Memasuki umur bangunan lebih dari sepuluh tahun, terlihat retakan-retakan yang mengkhawatirkan pada sambungan balok – kolom juga retakan yang ada di hampir semua bagian dinding bangunan baik itu dilantai satu maupun di lantai dua. Adanya retakan yang terihat jelas ini, mengakibatkan ketidaknyamanan bagi para pemakai bangunan baik itu Pegawai Pemerintah Daerah ataupun Masyarakat yang sesekali datang untuk melakukan pembayaran registrasi dan identifikasi kendaraan bermotor.
Tujuan Penelitain ini adalah : (1) Mengetahui Jenis kerusakan yang terjadi Pada Gedung Samsat Rajabasa; (2) Mengetahui Kuat Tekan Beton Gedung Samsat Rajabasa, (3) Mengetahui Kedalaman Tanah Keras di Sekitar Bangunan Gedung Samsat Rajabasa.
Berdasarkan Pengamatan langsung di lapangan, Pengujian Hammer Test dan Pengujian Sondir yang dilakukan didapat kesimpulan bahwa nilai kuat tekan (fc’) beton struktur eksisting gedung kurang dari nilai kuat tekan beston struktur yang disyaratkan oleh SNI dalam Persyaratan Beton Struktural Untuk Bangunan Gedung Standar Nasional Indonesia
Penerapan Konsep Bioklimatik dalam Penggunaan Secondary Skin pada Pembangunan Kawasan Perkantoran Kecamatan Setu Kota Tangerang Selatan
Authors: Suryani Anik , Despa Dikpride , Septiana Trisya 
Published: October 2023

Iklim di Indonesia khususnya di Kota Tangerang Selatan adalah iklim tropis dengan kecenderungan panas sehingga dalam proses desain dan pembangunan haruslah memperhatikan unsur bioklimatis. Proses mendesain dan membangun yang tidak mempertimbangkan faktor kondisi alam akan menyebabkan munculnya potensi penurunan kualitas lingkungan hidup yang diakibatkan oleh konsumsi energi pada bangunan. Terjadinya fenomena perubahan iklim global yang menumbuhkan bangunan boros energi dalam kenyamanan fisik bangunan juga melatarbelakangi perlunya penerapan konsep bioklimatik dalam pembangunan khususnya pembangunan gedung pemerintahan. Penerapan Prinsip Bioklimatik pada bangunan sangat penting, Pendekatan Bioklimatik juga dipilih dalam metode desain untuk mencapai penghematan energi dan pengurangan konsumsi energi yang tidak terbarukan. Oleh karena itu, prinsip-prinsip bioklimatik harus diterapkan pada lingkup bangunan khususnya bangunan pemerintah yang digunakan dalam pelayanan kepada masyarakat khususnya masyarakat Kota Tangerang Selatan. Tujuan dari penelitian ini adalah menganalisa penerapan konsep Bioklimatik di pembangunan Kawasan Perkantoran Kecamatan Setu Kota Tangerang Selatan dalam penggunaan secondary skin. Penelitian ini dilakukan dengan menggunakan metode analisis deskriptif. Hasil penelitian menunjukkan bahwa Pembangunan Kawasan Perkantoran Kecamatan Setu Kota Tangerang Selatan sebagai objek penelitian ini menerapkan konsep bioklimatik. Penggunaan secondary skin merupakan salah satu penerapan konsep bioklimatik pada pembangunan bangunan pemerintah di Kota Tangerang Selatan.
ANALISIS KEBUTUHAN BUS RAPID TRANSIT RUAS MALL BOEMI KEDATON – INSITUT TEKNOLOGI SUMATERA BERDASARKAN BRT STANDARD
Authors: Arifin Bustam Hadyan , Purba Aleksander , Zulian Arsy Ferdy 
Published: October 2023

Mall Boemi Kedaton menuju kampus Institut Teknologi Sumatera menjadi salah satu ruas yang tidak memiliki angkutan umum yang terintegrasi dengan pemerintah daerah langsung. Oleh karena itu, hal tersebut menjadi permasahalan yang akan peneliti analisis. Penelitian analisis kebutuhan angkutan umum bus untuk ruas Mall Boemi Kedaton - Institut Teknologi Sumatera dibutuhkan guna mengetahui potensi, karakteristik, besarnya permintaan dan bangkitan pengguna angkutan BRT, sistem operasionaI BRT dan BRT Rankings berdasarkan BRT Standards yang didapat dalam menganalisis kebutuhan BRT yang dapat diimplementasikan di ruas tersebut, sehingga dapat mengurangi masalah-masalah transportasi dan ketergantungan pada kendaraan pribadi. Tujuan penelitian ini yaitu menganalisis potensi penumpang ruas MBK – ITERA, menganalisis kebutuhan armada bus yang dibutuhkan, dan merencanakan fasilitas pendukung untuk BRT berdasarkan BRT Standard. Berdasarkan hasil penelitian didapatkan yaitu potensi penumpang didapatkan sebanyak 5.476 orang dengan menggunakan metode Departemen Perhubungan (2002) dan juga penyebaran kuisioner. Armada yang dibutuhkan untuk trayek BRT ini setelah dihitung dengan metode Departemen Perhubungan (2002) yaitu sebanyak 18 bus dengan waktu antara 8 menit dan 15 trip setiap armada. Halte yang dibutuhkan dalam perencanaan BRT ini yaitu sebanyak 11 halte dengan jarak 0,6 – 1,1 km. Perencanaan fasilitas pendukung sesuai dengan BRT Standard yang disesuaikan dengan keadaan trayek didapatkan sebanyak 68 poin dengan sebanyak 18 elemen dari 30 elemen yang terdapat pada BRT Standard.
Pembenihan Saccharomyces cerevisiae pada unit fermentor benih menggunakan substrat komplek secara batch homogen aerobik sebelum fermentasi etil alkohol
Authors: AGUSTIAN JONI , SUKMANA IRZA , SUHARNO SUHARNO 
Published: October 2023

Pembenihan mikrooganisme Saccharomyces cerevisiae dengan cermat sebelum produksi etanol secara fermentasi dilakukan agar tersedia bibit dalam jumlah memadai yang dilaksanakan didalam unit fermentor benih. Karena zat glukosa tersedia di Lampung, maka diperlukan untuk mempelajari pembenihan S. cerevisiae menggunakan bahan lokal tersebut sebagai makanannya. Pembenihan secara aerobik dilakukan dengan cukup baik dimana OD yang cukup tinggi (sebesar 3,38) diperoleh setelah 10 jam operasi tangki fermentor benih. Penurunan kandungan glukosa ke konsentrasi < 1mG/mL dalam waktu 12 jam mengindikasikan keberhasilan pembenihan, yang diperkuat dengan perolehan berat kering sebesar 0,5 mG/mL setelah 10 jam. Suplai oksigen kedalam media pembenihan digunakan dengan aktif oleh mikroorganisme selama 10 jam awal pengoperasian tangki fermentor. Pelepasan karbon dioksida dan penyerapan senyawa nitrogen dapat diamati pada proses pembiakan ini.