bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venolaryngeal Obstruction Syndrome (VLOS): Characterizing Airway Obstruction in Massive Thyroid Goiters
Authors: Compton Evan C. , Johnson Christopher M. , Postma Gregory N. , Terris David J. 
Published: February 2025

Objectives: Characterize the presentation of chronic airway obstruction for patients presenting with massive thyroid goiters. Methods: Demographic data acquisition was undertaken on 5 patients who presented with a compressive goiter and had pre-operative severe airway obstruction secondary to supraglottic and laryngeal edema. Each patient had a resolution of severe airway obstruction post-thyroidectomy. Results: In all, 5 patients were diagnosed with severe airway obstruction due to chronic obstruction by a thyroid goiter. Several airway management interventions were pursued during definitive surgery (conventional or videolaryngoscopic intubation and a hybrid endoscopic approach incorporating the Seldinger technique). Successful thyroidectomy led to rapid resolution of laryngeal edema. Conclusion: Venolaryngeal obstruction syndrome is proposed as a term to describe the laryngeal findings in compressive goiters. The pathophysiological sequence resulting in chronic airway obstruction may have similar mechanisms to expanding neck hematomas after thyroid surgery.
Baicalein protects against heart failure by improving mitochondrial dysfunction and regulating endoplasmic reticulum stress to reduce apoptosis in vitro and in vivo
Authors: Zhang Zhao , Zhang Xuan , Yang Yan , Wang HongYang , Yang Xiangjun , Xuan Liying , Yang Danli , Zhang Guoyou , Wang Yu 
Published: February 2025

Objectives: Baicalein, a flavonoid derived from the roots of Scutellaria baicalensis Georgi, demonstrates multifarious pharmacological effects due to its high antioxidant activity. However, the latent mechanisms remain insufficiently resolved. In the present research, we evaluated the therapeutic effects of baicalein on isoprenaline (ISO)-induced heart failure and investigated the possible underlying mechanisms. Methods: Toxicity was analyzed in zebrafish embryos and mouse atrial myocytes HL-1. The MTT assay was used to evaluate the effectiveness of baicalein. DCFH-DA was used as a fluorescence probe to detect intracellular reactive oxygen species (ROS). Superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) levels were measured using SOD, MDA and GSH-Px commercial kits. Adult BALB/c mice were randomized into six groups of ten animals each. Cardiac function was analyzed by echocardiographic images. Structural changes were analyzed by hematoxylin & eosin (HE) staining, Masson staining and TUNEL staining. The mechanism of baicalein was investigated by analyzing relative signaling pathways through western blotting. Results: Our studies show that baicalein both significantly reduces ISO-induced oxidative stress, apoptosis and cardiac fibrosis in vitro and vivo, this phenomenon was related to mitochondrial fusion/fission balance and inhibiting GRP78/CHOP pathway. Conclusions: Our results suggested that baicalein controls mitochondrial fusion/fission balance and inhibits GRP78/CHOP pathway, thus exerting therapeutic effects in ISO-induced heart failure in HL-1 cells and BALB/c mice. These results suggested that baicalein may be a potential therapeutic agent for heart failure.
Liposomal Bupivacaine for Additional Analgesia at Iliac Crest Donor Site in Alveolar Bone Graft Surgery: A Retrospective Pilot Study
Authors: Sampson Daniel E. , Tibesar Robert , Tibesar Maria , Finch Mike , Rabusch Stacey , Raschka Michael 
Published: February 2025

To study postoperative pain control differences between liposomal bupivacaine (LB) and immediate-release bupivacaine (IRB) as measured by the use of narcotics after iliac crest graft harvesting for alveolar bone grafting (ABG). A retrospective review was completed at a single-site pediatric stand-alone hospital of patients undergoing ABG with iliac crest bone grafting (ICBG) between May 1, 2020, through May 31, 2023. Patients, Participants Patients who underwent ABG with ICBG were split into three cohorts: LB monotherapy, IRB monotherapy, or LB with IRB. Interventions All ABG and ICBG procedures were completed by a single surgeon who is a member of our dedicated cleft lip and palate team. Main Outcome Measures The primary outcome was the difference in oral morphine equivalent (OME) requirements from the immediate postoperative time period to the time of discharge. Patients treated with LB monotherapy required significantly less OME during their inpatient stay, with an average of 0.21 mg/kg ± 0.15 mg/kg in the LB group, 0.67 mg/kg ± 0.37 mg/kg in the IRB group, and 0.28 mg/kg ± 0.07 mg/kg in the LB with IRB group ( P = .001). There was no significant difference in the total number of analgesic medication doses administered throughout the hospitalization among the three groups. Utilization of LB intraoperatively may decrease the need for postoperative opioid treatment for postoperative pain control when harvesting ICB for ABG in the cleft lip and palate population compared to alternative local anesthetics.
Severe acetabular bone loss management: is there still a role for titanium cages and cemented cups?
Authors: Perticarini Loris , Andriollo Luca , Rossi Stefano M P , Sangaletti Rudy , Benazzo Francesco 
Published: February 2025

Introduction: Bone loss represents a formidable challenge in hip revision surgery. Recent advances in revision implants and the use of new materials have diminished the need for cup-cages in addressing severe acetabular bone loss, which, however, may still be indicated in certain situations. The objectives of this study are to assess survival, functional outcomes, and reasons for the failure of managing severe acetabular bone loss with titanium cages and cemented cup. Methods: 57 patients treated with an acetabular cage and cemented cup for acetabular revision between January 2014 and July 2018 were retrospectively evaluated. Inclusion criteria comprised cup loosening with bone loss greater than IIB according to Paprosky classification, and a follow-up of at least 60 months. Results: The average age at the time of surgery was 74.8 years (SD 10.7). The acetabular bone defect according to the Paprosky classification was: type II C in 10 patients (21.7%), type III A in 21 patients (45.7%) and type III B in 15 patients (32.6%). Pelvic discontinuity was present in 35 cases (76.1%). The average follow-up during the final assessment was 78.3 months (SD 14.9). The reoperation rate was 13% (6 patients) and the complications rate was 17.4%. The survivorship of the implant was 87% at final follow-up. At the final follow-up average HHS was 89.4 ± 13.4, average WOMAC 15.7 ± 17.2, average HOOS 81.3 ± 19 and average FJS-12 83.7 ± 17.2. At the final follow-up, 32 patients (80%) showed excellent or good outcomes (HHS >80). Conclusions: In the presence of severe bone defects, acetabular reconstruction using titanium acetabular cages and cemented UHMWPE cups remains a valid treatment option. Specifically, this acetabular reconstruction system should be favoured for elderly or low-demand patients, with the possibility of using it safely even in patients with pelvic discontinuity.
Advancing the Treatment Paradigm for Multivessel Coronary Artery Disease: Hybrid Coronary Revascularization
Authors: Patel Parth M. , Arrington Ryon L. , Jonsson Amalia , Wei Jane W. , Binongo Jose , Devireddy Chandan , Nicholson William , Jaber Wissam , Rinfret Stephane , Halkos Michael E. 
Published: February 2025

Objective: The purpose of this study was to examine the longitudinal safety and efficacy of hybrid coronary revascularization (HCR) in a large cohort of patients with multivessel coronary artery disease (CAD). Methods: From 2009 to 2020, 561 consecutive patients (median age 64.0 years, predicted risk of mortality 1.3% ± 1.8%, 403 with 2-vessel disease and 158 with 3-vessel disease) underwent a planned HCR procedure with a robot-assisted off-pump left internal mammary artery to left anterior descending (LIMA-LAD) coronary artery bypass graft (CABG) combined with percutaneous coronary intervention (PCI) of non–LAD vessels. Multivariable regression analysis was used to identify risk factors for short-term and longer-term outcomes. Results: Operative mortality and stroke occurred in 4 (0.7%) and 5 patients (0.9%), respectively. Postoperative angiography revealed LIMA patency in 415 of 425 patients (98%). Median follow-up was 4.5 years and was 93% complete. Repeat revascularization occurred in 44 patients (8%) at a median of 2.7 years. Freedom from repeat revascularization and survival at 5 years was similar between patients with 2-vessel and 3-vessel disease ( P = 0.73 and P = 0.19, respectively). Completely revascularized patients had 5-year survival of 91% versus 64% for incompletely revascularized patients (hazard ratio = 3.8, P < 0.001). Age ( P = 0.03), renal failure ( P < 0.001), and history of myocardial infarction ( P = 0.01) were risk factors for late adverse events. Conclusions: HCR is a safe and effective minimally invasive alternative to conventional CABG or multivessel PCI with a low incidence of late repeat revascularization and mortality. HCR can be safely applied to carefully selected patients with either 2-vessel or 3-vessel CAD; however, incomplete revascularization may result in lower long-term survival.
Cortical α4β2-nicotinic acetylcholine receptors and cognitive decline in Parkinson's disease
Authors: Mills Kelly A , Kuwabara Hiroto , Du Yong , Gomez Gabriela , Motley Chelsie S , Skorobogatova Yana , Spiro Ergi , Coughlin Jennifer M , Lesniak Wojciech , Brandt Jason , Kamath Vidya , Pomper Martin G , Smith Gwenn S 
Published: February 2025

Background Autopsy and in vivo molecular imaging studies suggest altered binding of the α4β2-nicotinic cholinergic receptor (α4β2-nAChR) with cognitive dysfunction in Parkinson's disease (PD). Objective To determine the relationship between cortical and hippocampal binding of the α4β2-nAChR with [18F]XTRA PET, a high-affinity radiotracer that enables quantification of α4β2-nAChR in these regions, and cognitive function in individuals with PD. Methods Individuals with PD (N = 32) and age-similar, controls without PD or dementia (N = 10) completed a cognitive assessment and one 90-min, [18F]XTRA PET scan. Metabolite-corrected arterial input function radioactivity time-activity curves were generated to obtain total distribution volume (VT) across 12 regions of interest (ROIs). [18F]XTRA binding was compared 1) between controls and people with PD and 2) between controls, persons with PD with normal cognition (PD-NC), and persons with PD with MCI (PD-MCI). Results [18F]XTRA binding was higher in the occipital cortex of the combined group of PD participants compared to age-similar controls. No regions showed lower binding in PD. VT with, but not without, partial volume correction was different between controls, PD-NC, and PD-MCI groups, and this was driven by higher binding in PD-MCI compared to controls. Regression of regional VT on cognitive domain T-scores, adjusting for age, showed that worse performance in visual-spatial memory tasks was associated with higher VT in the precuneus and the entire parietal cortex. Conclusions Higher α4β2-nAChR binding in posterior cortical regions is found in PD and associated with worse visual perception and memory, possibly due to lower receptor occupancy by endogenous acetylcholine.
Potential of glycerol as a bio-based wood adhesive
Authors: Lu Jianshu , Umeshita Tomofumi , Sakai Shunsuke , Matsuo-Ueda Miyuki , Ando Daisuke , Chen Shuoye , Umemura Kenji 
Published: February 2025

Abstract
The development of bio-based adhesives, to the extent possible without harmful chemicals derived from fossil resources, is very important for the sustainable use of wood-based materials. In this study, we investigated the possibility of glycerol as a bio-based adhesive by manufacturing wood-based moldings. The raw materials used were glycerol and wood powder of Japanese cedar (Cryptomeria japonica). The moldings were manufactured under hot-pressed at 160–220 °C and 4 MPa for 10 min. The glycerol content varied from 0 to 30 wt%. Color differences in the resulting molding increased with increasing glycerol content and hot-press temperature, suggesting that chemical changes occur during hot pressing in the presence of glycerol. The best bending properties of the moldings were obtained under manufacturing conditions of 15 wt% glycerol and 220 °C. In the water resistance test using boiling water, weight gain and thickness swelling of moldings were inhibited with increasing glycerol content. The moldings manufactured at hot-press temperatures above 200 °C developed water resistance. Ether linkages were detected by Fourier transform infrared spectroscopy and heteronuclear single quantum coherence nuclear magnetic resonance spectroscopy. Our results demonstrated that good adhesiveness is achieved by ether linkages resulting from the chemical reaction between glycerol and wood powder.
Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized controlled trial
Authors: Kye Bong-Hyeon , Kim Ji-Hoon , Kim Hyung-Jin , Lee Yoon-Suk , Lee In-Kyu , Kang Won Kyung , Cho Hyeon-Min , Park Jong-Kyung , Ahn Chang-Hyeok , Lee Jae-Im , Oh Seong-Taek , Choi Byung Jo 
Published: February 2025

Abstract

Background
For obstructive colon cancer, many studies have been conducted on the use of self-expandable metallic stents (SEMS) as a bridge to surgery (BTS). However, there are currently no available prospective data on the impact of bridging period and there is a lack of research on the effects of neoadjuvant chemotherapy during the bridging period.

Objectives
Patients who undergo successful SEMS placement for obstructive left-sided colon adenocarcinoma without metastases will be eligible for this study.

Design
This study is a multicenter, non-inferiority, randomized (1:1), open-label, controlled trial.

Methods & analysis
The patients assigned to the control group will undergo curative surgery within two weeks after successful SEMS placement. The patients assigned to the experimental group will undergo three cycles of neoadjuvant FOLFOX chemotherapy within two weeks after successful SEMS placement. Curative surgery will be performed within four weeks of the last administration of neoadjuvant FOLFOX. Circulating tumor DNA (ctDNA) will be collected at specific time points.

Discussion
The optimal time interval for SEMS placement as a BTS can significantly impact long-term oncologic outcomes. In this study, our goal is to identify the optimal time interval for SEMS placement as a BTS. Recently, there has been interest in applying neoadjuvant chemotherapy for locally advanced colon cancer. In the context of early treatment for tumor dissemination following SEMS placement, neoadjuvant chemotherapy may be beneficial for delayed surgery after SEMS placement as a BTS. The results of this trial will be an important reference for the application of neoadjuvant chemotherapy in locally advanced colon cancer. Additionally, researchers will investigate whether ctDNA can serve as a reliable indicator to guide decisions about the timing and type of subsequent treatment. Based on the results of this trial, a patient-tailored treatment strategy can be developed for obstructive colon cancer.

Registration
This study is registered on ClinicalTrials.gov Identifier: NCT04889820, registered on May 17, 2021 in clinicaltrials.gov; Protocol ID: XC21MIDI0004.
I tweet, therefore I am: a systematic review on social media use and disorders of the social brain
Authors: Yang Nancy , Crespi Bernard 
Published: February 2025

Abstract
With rapid technological advances, social media has become an everyday form of human social interactions. For the first time in evolutionary history, people can now interact in virtual spaces where temporal, spatial, and embodied cues are decoupled from one another. What implications do these recent changes have for socio-cognitive phenotypes and mental disorders? We have conducted a systematic review on the relationships between social media use and mental disorders involving the social brain. The main findings indicate evidence of increased social media usage in individuals with psychotic spectrum phenotypes and especially among individuals with disorders characterized by alterations in the basic self, most notably narcissism, body dysmorphism, and eating disorders. These findings can be understood in the context of a new conceptual model, referred to here as ‘Delusion Amplification by Social Media’, whereby this suite of disorders and symptoms centrally involves forms of mentalistic delusions, linked with altered perception and perpetuation of distorted manifestations of the self, that are enabled and exacerbated by social media. In particular, an underdeveloped and incoherent sense of self, in conjunction with ‘real life’ social isolation that inhibits identify formation and facilitates virtual social interactions, may lead to use of social media to generate and maintain a more or less delusional sense of self identity. The delusions involved may be mental (as in narcissism and erotomania), or somatic (as in body dysmorphic disorder and eating disorders, encompassing either the entire body or specific body parts). In each case, the virtual nature of social media facilitates the delusionality because the self is defined and bolstered in this highly mentalistic environment, where real-life exposure of the delusion can be largely avoided. Current evidence also suggests that increased social media usage, via its disembodied and isolative nature, may be associated with psychotic spectrum phenotypes, especially delusionality, by the decoupling of inter and intra-corporeal cues integral to shared reality testing, leading to the blurring of self-other boundaries.
“I definitely cannot afford to be feeling poorly if there’s no need to be”: a qualitative evaluation of antiviral uptake following suspected occupational exposure to avian influenza
Authors: Pae Riinu , Findlater Lucy , Amlôt Richard , Capelastegui Fernando , Dabrera Gavin , Humphreys Clare , Kumbang Jharna , Oliver Isabel 
Published: February 2025

Abstract

Background
Growing numbers of people have been potentially exposed to avian influenza (AI), as the United Kingdom has managed the largest and most sustained series outbreaks in recent years. Antiviral medication is recommended for exposed individuals for chemoprophylaxis to reduce the severity of illness and the likelihood of secondary transmission. However, some individuals have been hesitant or declined antivirals. In this study, we aimed to identify the factors affecting the uptake of and adherence to antiviral medication.

Methods
We interviewed 14 individuals occupationally exposed to avian influenza and conducted focus groups with 15 public health professionals involved in advising and arranging antivirals. The data were analysed thematically based on COM-B factors (capability, opportunity, motivation).

Results
Although participants saw avian influenza as a severe disease, most did not consider themselves susceptible to it because they felt safe in personal protective equipment and knew that bird-to-human transmission was rare. The biggest barrier to uptake and adherence was experiencing side effects, especially if these disrupted day-to-day life or work. Participants who took antivirals followed medical advice in a novel situation, had health conditions or vulnerable family members they wanted to protect. As responding to an outbreak was exhausting, easy access to antivirals for those at most risk was considered important for improving uptake.

Conclusions
The factors affecting antiviral uptake were multifaceted. Public health interventions should prioritise those at most risk and address multiple components of behaviour, such as advising how to manage side effects, addressing concerns about long-term usage and providing convenient access to antivirals for those at most risk.
Continuous overnight monitoring of body temperature during embryo transfer cycles as a proxy for establishing progesterone fluctuations by comparison with P4 blood progesterone results: a prospective, observational study
Authors: Knowles T.G. , García-Velasco J.A. , Toribio M. , Garrido N. , Barrio Pedraza A.I. , Colomé Rakosnik C. , Salazar Vera A. , Milnes R. 
Published: February 2025

Abstract

Background
A prospective, observational study to identify relationships between body temperature and levels of peripheral P4 blood progesterone, and examine if these differ according to body temperature cycle pattern.

Methods
62 data points from 18 patients undergoing hormone assisted embryo transfer cycles at IVIRMA IVF clinics in Madrid, Mallorca and Malaga, Spain volunteered to use OvuSense, an intra-vaginal body temperature monitor. Primary outcome measures were OvuSense Raw and Smooth Temperature (ST) (°C), P4 (ng/ml). Secondary outcome measures: Ongoing Pregnancy, Miscarriage or biochemical pregnancy. Graphical time based comparison analyses and multilevel regression analyses using MLwiN 3.10 [Charlton C, Rasbash J, Browne WJ, Healy M, Cameron B. MlwiN Version 3.10. Centre for Multilevel Modelling. University of Bristol; 2024.] software were conducted.

Results
A graphical analysis showed an apparent relationship between P4 levels and Temperature taken on P4 blood draw day. A multilevel regression analysis using MLwiN 3.10 Centre for Multilevel Modelling. University of Bristol software investigated this relationship, allowing between-patient variation to be accounted for and estimated. This established a strong linear relationship between LnP4 and ST, and cross correlation was carried out which identified the optimum predictor of levels of LnP4 was ST measured on the day prior to blood sampling. Further graphical analyses showed an apparent lower luteal level of P4 for cycles flagged as atypical by OvuSense, and for negative outcomes, except on embryo transfer day.

Conclusions
The results provide extremely strong evidence of a linear relationship between LnP4 and Smooth Temperature (ST) measured the day before blood sampling (Z = 15.6, p < 0.0001, 2 sided). This suggests that ST could provide a less invasive, continuous, and more practical method of assessing P4 response. Secondary outcomes may be related to ST pattern established during an embryo transfer cycle. Further investigation is required to establish the value of the ST pattern for improving outcomes.
Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits
Authors: Okamoto Jeffrey , Yin Xianyong , Ryan Brady , Chiou Joshua , Luca Francesca , Pique-Regi Roger , Im Hae Kyung , Morrison Jean , Burant Charles , Fauman Eric B. , Laakso Markku , Boehnke Michael , Wen Xiaoquan 
Published: February 2025

Abstract
We present multi-integration of transcriptome-wide association studies and colocalization (Multi-INTACT), an algorithm that models multiple “gene products” (e.g., encoded RNA transcript and protein levels) to implicate causal genes and relevant gene products. In simulations, Multi-INTACT achieves higher power than existing methods, maintains calibrated false discovery rates, and detects the true causal gene product(s). We apply Multi-INTACT to GWAS on 1408 metabolites, integrating the GTEx expression and UK Biobank protein QTL datasets. Multi-INTACT infers 52 to 109% more metabolite causal genes than protein-alone or expression-alone analyses and indicates both gene products are relevant for most gene nominations.