bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic test accuracy of machine learning algorithms for the detection intracranial hemorrhage: a systematic review and meta-analysis study
Authors: Maghami Masoud , Sattari Shahab Aldin , Tahmasbi Marziyeh , Panahi Pegah , Mozafari Javad , Shirbandi Kiarash 
Published: December 2023

Abstract
Background
This systematic review and meta-analysis were conducted to objectively evaluate the evidence of machine learning (ML) in the patient diagnosis of Intracranial Hemorrhage (ICH) on computed tomography (CT) scans.

Methods
Until May 2023, systematic searches were conducted in ISI Web of Science, PubMed, Scopus, Cochrane Library, IEEE Xplore Digital Library, CINAHL, Science Direct, PROSPERO, and EMBASE for studies that evaluated the diagnostic precision of ML model-assisted ICH detection. Patients with and without ICH as the target condition who were receiving CT-Scan were eligible for the research, which used ML algorithms based on radiologists' reports as the gold reference standard. For meta-analysis, pooled sensitivities, specificities, and a summary receiver operating characteristics curve (SROC) were used.

Results
At last, after screening the title, abstract, and full paper, twenty-six retrospective and three prospective, and two retrospective/prospective studies were included. The overall (Diagnostic Test Accuracy) DTA of retrospective studies with a pooled sensitivity was 0.917 (95% CI 0.88–0.943, I2 = 99%). The pooled specificity was 0.945 (95% CI 0.918–0.964, I2 = 100%). The pooled diagnostic odds ratio (DOR) was 219.47 (95% CI 104.78–459.66, I2 = 100%). These results were significant for the specificity of the different network architecture models (p-value = 0.0289). However, the results for sensitivity (p-value = 0.6417) and DOR (p-value = 0.2187) were not significant. The ResNet algorithm has higher pooled specificity than other algorithms with 0.935 (95% CI 0.854–0.973, I2 = 93%).

Conclusion
This meta-analysis on DTA of ML algorithms for detecting ICH by assessing non-contrast CT-Scans shows the ML has an acceptable performance in diagnosing ICH. Using ResNet in ICH detection remains promising prediction was improved via training in an Architecture Learning Network (ALN).
Upregulation of S100A8 in peripheral blood mononuclear cells from patients with depression treated with SSRIs: a pilot study
Authors: Gamboa-Sánchez Concepción , Becerril-Villanueva Enrique , Alvarez-Herrera Samantha , Leyva-Mascareño Gabriela , González-López Sandra L. , Estudillo Enrique , Fernández-Molina Alberto E. , Elizalde-Contreras José Miguel , Ruiz-May Eliel , Segura-Cabrera Aldo , Jiménez-Genchi Janeth , Pavón Lenin , Zamudio Sergio Roberto , Pérez-Sánchez Gilberto 
Published: December 2023

Abstract
Background
Major depressive disorder (MDD) affects more than 350 million people worldwide, and there is currently no laboratory test to diagnose it. This pilot study aimed to identify potential biomarkers in peripheral blood mononuclear cells (PBMCs) from MDD patients.

Methods
We used tandem mass tagging coupled to synchronous precursor selection (mass spectrometry) to obtain the differential proteomic profile from a pool of PBMCs from MDD patients and healthy subjects, and quantitative PCR to assess gene expression of differentially expressed proteins (DEPs) of our interest.

Results
We identified 247 proteins, of which 133 had a fold change ≥ 2.0 compared to healthy volunteers. Using pathway enrichment analysis, we found that some processes, such as platelet degranulation, coagulation, and the inflammatory response, are perturbed in MDD patients. The gene-disease association analysis showed that molecular alterations in PBMCs from MDD patients are associated with cerebral ischemia, vascular disease, thrombosis, acute coronary syndrome, and myocardial ischemia, in addition to other conditions such as inflammation and diabetic retinopathy.

Conclusions
We confirmed by qRT-PCR that S100A8 is upregulated in PBMCs from MDD patients and thus could be an emerging biomarker of this disorder. This report lays the groundwork for future studies in a broader and more diverse population and contributes to a deeper characterization of MDD.
Public satisfaction with health system after healthcare reform in China
Authors: Kang Lili , Zhang Tianyi , Xian Bensong , Li Changle , Khan M. Mahmud 
Published: December 2023

AbstractBackgroundThe Chinese central government launched the third phase of health system reforms in 2009. After a decade since the initiation of the reform, the health system has witnessed noteworthy gains. However, there is no concurrent improvement in public satisfaction with the health system. This study analysed various factors that influence public satisfaction with the system and examined whether perceived quality of care affects public satisfaction.MethodsA longitudinal nationally representative survey was used for this study. We used five waves of China Family Panel Studies (CFPS) survey data. The final sample consisted of 145 843 observations. A two-way fixed-effects ordered logistic model was used for the analysis.ResultsThe results indicate that perceived good quality of care was positively associated with public satisfaction in health system regardless of rural–urban residence. Older adults and individuals with more than 3 years of college education were less likely to be satisfied with the system in rural areas. Personal income and the density of medical professionals in the geographic area tend to improve public satisfaction in rural areas. Having medical insurance coverage and fair or good self-rated health improved the probability of reporting public satisfaction in urban areas. Married people and individuals who lived in the West region were less likely to be satisfied with the health system in urban areas.ConclusionsKnowledge and skills of healthcare providers or physical quality of facilities are not sufficient in improving public satisfaction in the health system. Policymakers need to identify options to influence the important factors that affect public perception of the system. This analysis identified several policy-amenable factors to improve public perception of the health system in rural and urban China.
Effect of changing the acquisition trajectory of the 3D C-arm (CBCT) on image quality in spine surgery: experimental study using an artificial bone model
Authors: Privalov Maxim , Bullert Benno , Gierse Jula , Mandelka Eric , Vetter Sven Y. , Franke Jochen , Grützner Paul A. , Swartman Benedict 
Published: December 2023

Abstract
Background
Intraoperative 3D imaging using cone-beam CT (CBCT) provides improved assessment of implant position and reduction in spine surgery, is used for navigated surgical techniques, and therefore leads to improved quality of care. However, in some cases the image quality is not sufficient to correctly assess pedicle screw position and reduction, especially due to metal artifacts. The aim of this study was to investigate whether changing the acquisition trajectory of the CBCT in relation to the pedicle screw position during dorsal instrumentation of the spine can reduce metal artifacts and consequently improve image quality as well as clinical assessability on the artificial bone model.

Methods
An artificial bone model was instrumented with pedicle screws in the thoracic and lumbar spine region (Th10 to L5). Then, the acquisition trajectory of the CBCT (Cios Spin, Siemens, Germany) to the pedicle screws was systematically changed in 5° steps in angulation (− 30° to + 30°) and swivel (− 30° to + 30°). Subsequently, radiological evaluation was performed by three blinded, qualified raters on image quality using 9 questions (including anatomical structures, implant position, appearance of artifacts) with a score (1–5 points). For statistical evaluation, the image quality of the different acquisition trajectories was compared to the standard acquisition trajectory and checked for significant differences.

Results
The angulated acquisition trajectory increased the score for subjective image quality (p < 0.001) as well as the clinical assessability of pedicle screw position (p < 0.001) highly significant with particularly strong effects on subjective image quality in the vertebral pedicle region (d = 1.06). Swivel of the acquisition trajectory significantly improved all queried domains of subjective image quality (p < 0.001) as well as clinical assessability of pedicle screw position (p < 0.001). The data show that maximizing the angulation or swivel angle toward 30° provides the best tested subjective image quality.

Summary
Angulation and swivel of the acquisition trajectory result in a clinically relevant improvement in image quality in intraoperative 3D imaging (CBCT) during dorsal instrumentation of the spine.
How do trial teams plan for retention during the design stage of the trial? A scoping review
Authors: Murphy Ellen , Gillies Katie , Shiely Frances 
Published: December 2023

Abstract
Background
Retention to trials is important to ensure the results of the trial are valid and reliable. The SPIRIT guidelines (18b) require “plans to promote participant retention and complete follow-up, including list of any outcome data to be collected for participants who discontinue or deviate from intervention protocols” be included in trial protocols. It is unknown how often protocols report this retention information. The purpose of our scoping review is to establish if, and how, trial teams report plans for retention during the design stage of the trial.

Materials and methods
A scoping review with searches in key databases (PubMed, Scopus, EMBASE, CINAHL (EBSCO), and Web of Science from 2014 to 2019 inclusive) to identify randomised controlled trial protocols. We produced descriptive statistics on the characteristics of the trial protocols and also on those adhering to SPIRIT item 18b. A narrative synthesis of the retention strategies was also conducted.

Results
Eight-hundred and twenty-four protocols met our inclusion criteria. RCTs (n = 722) and pilot and feasibility trial protocols (n = 102) reported using the SPIRIT guidelines during protocol development 35% and 34.3% of the time respectively. Of these protocols, only 9.5% and 11.4% respectively reported all aspects of SPIRIT item 18b “plans to promote participant retention and to complete follow-up, including list of any outcome data for participants who discontinue or deviate from intervention protocols”.
Of the RCT protocols, 36.8% included proactive “plans to promote participant retention” regardless of whether they reported using SPIRIT guidelines or not. Most protocols planned “combined strategies” (48.1%). Of these, the joint most commonly reported were “reminders and data collection location and method” and “reminders and monetary incentives”. The most popular individual retention strategy was “reminders” (14.7%) followed by “monetary incentives- conditional” (10.2%). Of the pilot and feasibility protocols, 40.2% included proactive “plans to promote participant retention” with the use of “combined strategies” being most frequent (46.3%). The use of “monetary incentives – conditional” (22%) was the most popular individual reported retention strategy.

Conclusion
There is a lack of reporting of plans to promote participant retention in trial protocols. Proactive planning of retention strategies during the trial design stage is preferable to the reactive implementation of retention strategies. Prospective retention planning and clear communication in protocols may inform more suitable choice, costing and implementation of retention strategies and improve transparency in trial conduct.
Effect of dapagliflozin on proteomics and metabolomics of serum from patients with type 2 diabetes
Authors: Liu Jia , Chang Xiaona , Ding Xiaoyu , He Xueqing , Wang Jiaxuan , Wang Guang 
Published: December 2023

Abstract
Background
Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduced the risk of cardiovascular and renal outcomes in patients with type 2 diabetes (T2D), but the underlying mechanism has not been well elucidated. The circulating levels of proteins and metabolites reflect the overall state of the human body. This study aimed to evaluate the effect of dapagliflozin on the proteome and metabolome in patients with newly diagnosed T2D.

Methods
A total of 57 newly diagnosed T2D patients were enrolled, and received 12 weeks of dapagliflozin treatment (10 mg/d, AstraZeneca). Serum proteome and metabolome were investigated at the baseline and after dapagliflozin treatment.

Results
Dapagliflozin significantly decreased HbA1c, BMI, and HOMA-IR in T2D patients (all p < 0.01). Multivariate models indicated clear separations of proteomics and metabolomics data between the baseline and after dapagliflozin treatment. A total of 38 differentially abundant proteins including 23 increased and 15 decreased proteins, and 35 differentially abundant metabolites including 17 increased and 18 decreased metabolites, were identified. In addition to influencing glucose metabolism (glycolysis/gluconeogenesis and pentose phosphate pathway), dapagliflozin significantly increased sex hormone-binding globulin, transferrin receptor protein 1, disintegrin, and metalloprotease-like decysin-1 and apolipoprotein A-IV levels, and decreased complement C3, fibronectin, afamin, attractin, xanthine, and uric acid levels.

Conclusions
The circulating proteome and metabolome in newly diagnosed T2D patients were significantly changed after dapagliflozin treatment. These changes in proteins and metabolites might be associated with the beneficial effect of dapagliflozin on cardiovascular and renal outcomes.
Performance of severity indices for admission and mortality of trauma patients in the intensive care unit: a retrospective cohort study
Authors: Rio Tatiane Gonçalves Gomes de Novais d , Nogueira Lilia de Souza , Lima Fernanda Rodrigues , Cassiano Carolina , Garcia Diogo de Freitas Valeiro 
Published: December 2023

Abstract
Background
Little is known about the performance of severity indices for indicating intensive care and predicting mortality in the Intensive Care Unit (ICU) of trauma patients. This study aimed to compare the performance of severity indices to predict trauma patients’ ICU admission and mortality.

Methods
A retrospective cohort study which analyzed the electronic medical records of trauma patients aged ≥ 18 years, treated at a hospital in Brazil, between 2014 and 2017. Physiological [Revised Trauma Score (RTS), New Trauma Score (NTS) and modified Rapid Emergency Medicine Score (mREMS)], anatomical [Injury Severity Score (ISS) and New Injury Severity Score (NISS)] and mixed indices [Trauma and Injury Severity Score (TRISS), New Trauma and Injury Severity Score (NTRISS), Base-deficit Injury Severity Score (BISS) and Base-deficit and New Injury Severity Score (BNISS)] were compared in analyzing the outcomes (ICU admission and mortality) using the Area Under the Receiver Operating Characteristics Curves (AUC–ROC).

Results
From the 747 trauma patients analyzed (52.5% female; mean age 51.5 years; 36.1% falls), 106 (14.2%) were admitted to the ICU and 6 (0.8%) died in the unit. The ISS (AUC 0.919) and NISS (AUC 0.916) had better predictive capacity for ICU admission of trauma patients. The NISS (AUC 0.949), TRISS (AUC 0.909), NTRISS (AUC 0.967), BISS (AUC 0.902) and BNISS (AUC 0.976) showed excellent performance in predicting ICU mortality.

Conclusions
Anatomical indices showed excellent predictive ability for admission of trauma patients to the ICU. The NISS and the mixed indices had the best performances regarding mortality in the ICU.
Effects of C and N application on Azotobacter and nitrogen cycle in farmland soils of central Guizhou, China
Authors: Qiao Zhiwei , Liu Chao , Yan Ru , Qin Shihua 
Published: December 2023

AbstractCarbon sources and nitrogen sources are two important groups of substances in analyses of the effects of exogenous additives on soil microorganisms. Glucose (present in soil) and urea (extensively used in agricultural production) are substances often used to study the specific effects of carbon and nitrogen addition on microorganisms. Azotobacter, a non-symbiotic nitrogen-fixing bacterium, has been characterized in the laboratory and applied to soil in numerous studies. However, soil microorganisms display considerable diversity, and the effects of in exogenous substances stimulation on various microorganisms are uncertain. The potential effects of forced exogenous substance stimulation on Azotobacter are not well understood. Here, the effects of C and N application on Azotobacter growth and nitrogen cycle metabolism in farmland soil in central Guizhou, China, were studied through analysis of four treatment groups: control (CK), glucose treatment (C), urea treatment (N), and glucose + urea treatment (CN). The results showed that the relative abundances of the Azotobacter genus and relevant species were increased in group C, indicating promotion of Azotobacter growth (P < 0.001). The relative abundances of the Azotobacter genus and relevant species in group CN were significantly different from the abundances in group N and CK (P < 0.05). Furthermore, the relative abundances of nif genes (i.e., nifH, nifD, and nifK) and nirD were significantly increased in group C. However, the relative abundances of the aforementioned four nitrogen cycle-related genes did not significantly differ between group CN and groups CK and N. The main source species of the aforementioned four nitrogen cycle-related genes were Azotobacter species. The total nitrogen and alkali-hydrolyzed nitrogen contents in soil did not significantly differ in a comparison between group C and groups N and CN. Piecewise structural equation modeling analysis revealed that bacterial α-diversity, Azotobacter, and nitrogen cycle genes had significant direct effects on the alkali-hydrolyzed nitrogen content in soil and had negligible direct effects on the total nitrogen content in soil. These findings improve the broader understanding of Azotobacter and provide theoretical support for reduced Azotobacter utilization in soil.
Graphical Abstract
Baby blues, premenstrual syndrome and postpartum affective disorders: intersection of risk factors and reciprocal influences
Authors: Chechko Natalia , Losse Elena , Frodl Thomas , Nehls Susanne 
Published: December 2023

Background
The aetiology and consequences of ‘baby blues’ (lower mood following childbirth) are yet to be sufficiently investigated with respect to an individual's clinical history.

Aims
The primary aim of the study was to assess the symptoms of baby blues and the relevant risk factors, their associations with clinical history and premenstrual syndrome (PMS), and their possible contribution to the early recognition of postpartum depression (PPD).

Method
Beginning shortly after childbirth, 369 mothers were followed up for 12 weeks. Information related to their clinical history, PMS, depression, stress and mother–child attachment was collected. At 12 weeks, mothers were classified as non-depressed, or with either PPD or adjustment disorder.

Results
A correlation was found between the severity of baby blues and PMS (r = 0.397, P < 0.001), with both conditions increasing the possibility of adjustment disorder and PPD (baby blues: OR = 6.72, 95% CI 3.69–12.25; PMS: OR = 3.29, 95% CI 2.01–5.39). Baby blues and PMS independently predicted whether a mother would develop adjustment disorder or PPD after childbirth (χ2(64) = 198.16, P < 0.001). Among the non-depressed participants, baby blues were found to be associated with primiparity (P = 0.012), family psychiatric history (P = 0.001), PMS (P < 0.001) and childhood trauma (P = 0.017).

Conclusions
Baby blues are linked to a number of risk factors and a history of PMS, with both conditions adding to the risk of PPD. The neuroendocrine effects on mood need be understood in the context of individual risk factors. The assessment of both baby blues and PMS symptoms within the first postpartum days may contribute to an early identification of PPD.
The Principle of Solidarity Within the Italian Constitution. Recent Issues and Developments in the European Context.
Authors: Mangione Gabriella 
Published: December 2023

The Constitution of the Italian Republic asserts the principle of solidarity in a particularly evident manner and marks one of the clearest instances and one of the most strongly enshrined manifestations of that principle within Europe. The centrality and pervasive way this watchword of the contemporary political and legal lexicon is used takes on a particular depth in the light of the immense tragedy of the migrants crossing the Mediterranean Sea, who for several years now have been knocking on the doors of Europe day after day, with a profound effect on the Old Continent. The word solidarity has taken on an even more dramatic depth since Russia launched an unprovoked war of aggression against its peaceful neighbour, Ukraine, resulting in a significant armed conflict in Europe and an increase in the number of refugees and asylum-seekers from Ukraine. In contrast to the weak and uncertain European solidarity towards those migrants who reach its southern boundaries, the EU’s solidarity towards the Ukrainian people has been clear and evident.
Validity of the Arbitration Clause in the International Employment Contract: the Viewpoint of the GCC Countries
Authors: Al-Sharaf Sharaf Khaled , Al-Tourah Anas Faisal 
Published: December 2023

In this paper we will evaluate the significance of the arbitration clause in international employment contracts. Our aim is to understand how this particular alternative dispute resolution (ADR) mechanism is utilized in the Gulf Cooperation Council (GCC) countries. Even though the law in several countries aims to protect employees by prohibiting arbitration agreements (due to considerations of employee protection), we argue that it should be optional for the employee to enter into labour agreements with arbitration clauses. This is especially important when the arbitration agreement achieves the employees’ interests, and is agreed upon with informed and clear consent. We will engage with arguments which advocate the prohibition of arbitration agreements within Individual Employment Contracts (IECs); whilst taking the position that the flexibility, speed, confidentiality and predictability of arbitration provides specific advantages to international employees compared to litigation before court. Furthermore, in the context of a desire on the side of GCC countries to attract high-skilled labour (and when there are many misconceptions regarding the adjudicative functions of labour law courts in the GCC), arbitration clauses can play a significant role in mediating between different legal cultures.