bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reporting reimbursement price decisions for onco-hematology drugs in Spain
Authors: Elvira David , Torres Ferran , Vives Roser , Puig Gemma , Obach Mercè , Gay Daniel , Varón Daniel , de Pando Thais , Tabernero Josep , Pontes Caridad 
Published: October 2023

IntroductionEven using well-established technology assessment processes, the basis of the decisions on drug price and reimbursement are sometimes perceived as poorly informed and sometimes may be seen as disconnected from value. The literature remains inconclusive about how Health Technology Assessment Bodies (HTAb) should report the determinants of their decisions. This study evaluates the relationship between oncology and hematology drug list prices and structured value parameters at the time of reimbursement decision in Spain.MethodsThe study includes all new onco-hematological products (22), with a first indication authorized between January 2017 and December 2019 in Spain and pricing decisions published up until October 2022. For each product, 56 contextual and non-contextual indicators reflecting the structured multiple criteria decision analysis (MCDA) – Evidence-based Decision-Making (EVIDEM) framework were measured. The relationship between prices and the MCDA-EVIDEM framework was explored using univariate statistical analyses.ResultsHigher prices were observed when the standard of care included for combinations, if there were references to long-lasting responses, for fixed-duration treatment compared to treatment until progression and treatment with lower frequencies of administration; lower prices were observed for oral administration compared to other routes of administration. Statistically significant associations were observed between prices and the median duration of treatment, the impact on patient autonomy, the ease of use of the drug, and the recommendations of experts.DiscussionThe study suggests that indicators related to the type of standard of care, references to long-lasting responders, the convenience of the use of the drug, and the impact of treatment on patient autonomy, as well as contextual indicators such as the existence of previous clinical consensus, are factors in setting oncology drug prices in Spain. The implementation of MCDA-EVIDEM methodologies may be useful to capture the influence on pricing decisions of additional factors not included in legislation or consolidated assessment frameworks such as the European Network for Health Technology Assessment (EunetHTA) core model. It may be opportune to consider this in the upcoming revision of the Spanish regulation for health technology assessments and pricing and reimbursement procedures.
Molecular Cloning, Heterologous Expression, Purification, and Evaluation of Protein–Ligand Interactions of CYP51 of Candida krusei Azole-Resistant Fungal Strain
Authors: Tsybruk Tatsiana V. , Kaluzhskiy Leonid A. , Mezentsev Yuri V. , Makarieva Tatyana N. , Tabakmaher Kseniya M. , Ivanchina Natalia V. , Dmitrenok Pavel S. , Baranovsky Alexander V. , Gilep Andrei A. , Ivanov Alexis S. 
Published: October 2023

Due to the increasing prevalence of fungal diseases caused by fungi of the genus Candida and the development of pathogen resistance to available drugs, the need to find new effective antifungal agents has increased. Azole antifungals, which are inhibitors of sterol-14α-demethylase or CYP51, have been widely used in the treatment of fungal infections over the past two decades. Of special interest is the study of C. krusei CYP51, since this fungus exhibit resistance not only to azoles, but also to other antifungal drugs and there is no available information about the ligand-binding properties of CYP51 of this pathogen. We expressed recombinant C. krusei CYP51 in E. coli cells and obtained a highly purified protein. Application of the method of spectrophotometric titration allowed us to study the interaction of C. krusei CYP51 with various ligands. In the present work, the interaction of C. krusei CYP51 with azole inhibitors, and natural and synthesized steroid derivatives was evaluated. The obtained data indicate that the resistance of C. krusei to azoles is not due to the structural features of CYP51 of this microorganism, but rather to another mechanism. Promising ligands that demonstrated sufficiently strong binding in the micromolar range to C. krusei CYP51 were identified, including compounds 99 (Kd = 1.02 ± 0.14 µM) and Ch-4 (Kd = 6.95 ± 0.80 µM). The revealed structural features of the interaction of ligands with the active site of C. krusei CYP51 can be taken into account in the further development of new selective modulators of the activity of this enzyme.
Plant-Disease-Suppressive and Growth-Promoting Activities of Endophytic and Rhizobacterial Isolates Associated with Citrullus colocynthis
Authors: Al-Shuaibi Badriya Khalfan , Kazerooni Elham Ahmed , Hussain Shah , Velazhahan Rethinasamy , Al-Sadi Abdullah Mohammed 
Published: October 2023

This study was conducted to investigate the antagonistic potential of endophytic and rhizospheric bacterial isolates obtained from Citrullus colocynthis in suppressing Fusarium solani and Pythium aphanidermatum and promoting the growth of cucumber. Molecular identification of bacterial strains associated with C. colocynthis confirmed that these strains belong to the Achromobacter, Pantoea, Pseudomonas, Rhizobium, Sphingobacterium, Bacillus, Sinorhizobium, Staphylococcus, Cupriavidus, and Exiguobacterium genera. A dual culture assay showed that nine of the bacterial strains exhibited antifungal activity, four of which were effective against both pathogens. Strains B27 (Pantoea dispersa) and B28 (Exiguobacterium indicum) caused the highest percentage of inhibition towards F. solani (48.5% and 48.1%, respectively). P. aphanidermatum growth was impeded by the B21 (Bacillus cereus, 44.7%) and B28 (Exiguobacterium indicum, 51.1%) strains. Scanning electron microscopy showed that the strains caused abnormality in phytopathogens’ mycelia. All of the selected bacterial strains showed good IAA production (>500 ppm). A paper towel experiment demonstrated that these strains improved the seed germination, root/shoot growth, and vigor index of cucumber seedlings. Our findings suggest that the bacterial strains from C. colocynthis are suppressive to F. solani and P. aphanidermatum and can promote cucumber growth. This appears to be the first study to report the efficacy of these bacterial strains from C. colocynthis against F. solani and P. aphanidermatum.
Probiotics in the Treatment and Prevention of Allergic Diseases
Authors: Титова Н.Д. 
Published: October 2023

Пробиотики являются многообещающим средством борьбы с эпидемией аллергии, основная концепция их применения основана на модуляции кишечной микробиоты и развитии детского иммунитета. В статье рассмотрены основные биологические механизмы, с помощью которых пробиотики оказывают благоприятное воздействие на организм человека, включая усиление барьерной функции, подавление патогенов и модуляцию иммунной системы. Обсуждена эффективность использования пробиотиков для профилактики развития аллергии у детей с позиций доказательной медицины, проанализированы данные последних систематических обзоров и метаанализов. Приведены данные рандомизированных клинических исследований по лечению атопического дерматита, астмы, аллергического ринита с использованием пробиотиков. Проведена оценка безопасности использования пробиотических микроорганизмов с учетом опубликованных в литературе сведений о возможных побочных реакциях. Учитывая неуклонный рост аллергических заболеваний, перспективным для лечения и профилактики аллергии (особенно в группах детей с высоким риском развития аллергии) является использование современных и высококачественных пробиотиков, имеющих доказанную клиническую эффективность и безопасность применения.
Probiotics are a promising tool in the fight against the allergy epidemic, the main concept of their use is based on the modulation of the intestinal microbiota and the development of children’s immunity. This article discusses the main biological mechanisms by which probiotics have a beneficial effect on the human organism, including the enhancement of barrier function, suppression of pathogens, and modulation of the immune system. The effectiveness of the use of probiotics to prevent the development of allergies in children is discussed from the standpoint of evidence-based medicine, the data of recent systematic reviews and meta-analyses are analyzed. The data of randomized clinical trials on the treatment of atopic dermatitis, asthma, allergic rhinitis using probiotics are presented. The safety of the use of probiotic microorganisms was assessed, taking into account the information published in the literature on possible adverse reactions. Considering the steady growth of allergic diseases, it is promising for the treatment and prevention of allergies (especially in groups of children with a high risk of developing allergies) to use modern and high-quality probiotics with proven clinical efficacy and safety of use.
NATURE PROTECTION FUND IN THE STRUCTURE OF RECREATION AND TOURIST NATURE USE OF CHERNIGOV REGION
Authors: Shovkun T. , Zinchenko V. , Myron I. 
Published: October 2023

The article analyzes the territories and objects of the nature reserve fund (NRF) of the Chernihiv region as objects of recreational and touristic nature use. The NRF of the Chernihiv region includes 678 objects with a total area of 263.1 thousand hectares (7.89% of the territory of the region). The NRF of the region consists of eight categories, there are no such categories as biosphere reserve, nature reserve and botanical garden. The study of the dynamics of the number of objects and areas of the NRF of the region for the period from 1990 to 2023 revealed a tendency to increase multifunctional protected areas (national natural parks (NNP) and regional landscape parks (RLP)). Reserves and natural monuments predominate in the structure of NRF of Chernihiv region in terms of number, and in terms of area - reserves and regional landscape parks.
It was established that the most important for the recreation and tourism sphere are the multifunctional categories of NRF - NNP and RLP, in which tourism is actively developing. The main directions of tourism development in the Mezyn and Ichnya National Parks were analyzed - ecological trails, routes (car, bicycle, pedestrian) that provide an opportunity to get to know the nature of Polissia (Mezyn National Park) and the Forest Steppe (Ichnya National Park), and tourist infrastructure are indicated. It was determined that the most common type of tourism within the NNP is walking along ecological trails.
A special issue is the use of the recreational potential of nature reserves, which are the most widespread in the structure of the NRF of the region. It has been established that the predominant type of recreational and tourist activity within their borders is educational excursions along marked trails. Other categories of NRF of the Chernihiv region (natural monuments, arboretum, zoo, parks-monuments of horticultural art) have less recreational potential, but have educational value and can act as objects of recreational and touristic nature use. In order to increase the role and significance of the NRF of Chernihiv region in the structure of recreational and touristic nature use, it is advisable to create such categories of NRF as NNP and RLP.
INFLUENCE OF WINTER WHEAT PLANTS’ FOLIAR ERTILIZATION ON CROP’S YIELD AND QUALITY
Authors: Kotkova T. , Dovbish L. 
Published: October 2023

The article presents the results of experimental studies on the effect of foliar fertilization of winter wheat plants of sort Amandus with complex water-soluble fertilizers NAIS grain and Accelerator Micro on the background of N100Р58К100 on grain yield and quality. The research was conducted at Normagro LLC, Berdychiv district, Zhitomir region. The experiment included fertilizing winter wheat plants at the IV-V stages of crop organogenesis. The research was conducted on gray forest loamy soils. The use of these fertilizers proved to be quite effective. Compared with the background, the addition of conventional fertilizer with the studied fertilizers contributed to the increase in ear length and increase in the number of ears in the ear. The effect of using Акселератор Мікро was especially noticeable. The addition of background doses of fertilizers to the studied foliar fertilizers in our experiment affected the mass fraction of the crop, as evidenced by the data. At fertilizer N100P58K100 – received a crop – 6,08 t/ha, at N100P58K100 + «NAIS grain», 1,5 l/ha – productivity was 6,56 t/ha, at N100P58K100 + «Accelerator Micro» 1,5 kg/ha – 6,78 t/ha. In addition, the effect of combining the usual doses of fertilizers with foliar fertilization on the formation of the structure of the ear of wheat was studied. Among the studied parameters were the weight of one ear, the weight of 1000 grains, the nature of the grain. The weight of the ear with fertilizer N100R58K100 was –1,12 g, with N100R58K100 + «NAIS grain» (1,5 l/ha) – 1,17 g, and with N100P58K100 + «Accelerator Micro» (1,5 kg/ha) – 1,21 g, weight of 1000 grains – 42,3 g, 45,6 g, 48,9 g and nature of grain – 735 g/l, 745 g/l, 751 g/l respectively. The effect of the use of these fertilizers on the quality of the grain seed, in particular on the content of protein, gluten, ash and glassiness of the grain, was positive. A significant increase was obtained with the use of «Accelerator Micro», compared with «NAIS grain».
Resonant tunneling injection of electrons through double stacked GaAs/InAs quantum dots with nanohole electrode
Authors: Nakazato Yuji , Miyashita Naoya , Yamaguchi Koichi 
Published: October 2023

Abstract
Resonant tunneling diodes containing closely double-stacked InAs quantum dots (QDs) were grown on GaAs substrates by MBE. After growing a thin GaAs capping layer on the double-stacked InAs QDs, nanoholes were selectively formed just above the larger second QDs by thermal annealing. The Au thin film was deposited directly on top surface of the larger second QDs through the nanoholes. The second QDs contacted with Au film served as conducting dots, which can locally inject electrons into the underlying first QDs. In current versus voltage (I–V) measurements, (dI/dV) peaks were clearly observed in the forward bias voltage region. It was due to the tunneling current through a non-doped GaAs thin layer between double-stacked QDs and n-GaAs conduction band. The (dI/dV) peaks shifted toward the lower forward voltage region with increasing temperature. It was explained by the temperature dependence of the electron energy distribution in the GaAs conduction band.
Study of anode doping and avalanche in foundry compatible 1.2 kV vertical GaN PiN diodes
Authors: Ebrish Mona A. , Porter Matthew , Jacobs Alan , Gallagher James C. , Kaplar Robert J. , Gunning Brendan P. , Hobart Karl D. , Anderson Travis J. 
Published: October 2023

Abstract
Foundry compatible vertical GaN PiN diodes were fabricated. The devices investigated in this work are based on 8 um drift layer thickness to achieve ∼1.2 kV of voltage blocking. Three different anode doping levels were fabricated on three wafers with the same p-layer thickness, and planar hybrid edge termination. The moderate anode doping level of 1 × 1018 cm−3 has achieved the highest breakdown voltage of 1.2 kV and its temperature-dependent breakdown behavior proved an avalanche behavior. Furthermore, our electroluminescence displayed the breakdown at the edge of the anode. Our simulation results imply an improvement in the field management with moderate anode doping.
HUBUNGAN IBU BERSALIN TERKONFIRMASI POSITIF COVID-19 DENGAN KEJADIAN ASFIKSIA PADA BAYI BARU LAHIR DI RSU LABUANG BAJI
Authors: Bakri Sri Handayani , Irfana  
Published: October 2023

COVID-19 menjadi perhatian serius dalam kesehatan masyarakat setelah dinyatakan sebagai pandemi. Kasus pertama COVID-19 dilaporkan terjadi di Wuhan pada tahun 2019 (Pradana, Casman, & Nur’aini, 2020). Pada awalnya WHO menyebut penyakit ini dengan nama Novel Coronavirus 2019 atau 2019-nCoV (Pradana et al., 2020). Kemudian pada tanggal 11 Februari 2020, WHO mengumumkan secara resmi COVID-19 sebagai penyakit yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Penelitian yang dilakukan oleh Elshafeey, dkk menyebutkan 368 orang ibu bersalin termasuk ke dalam kasus ringan, 14 orang memiliki kasus parah dan 3 orang lainnya termasuk kasus yang kritis. Pada saat melahirkan, dilaporkan masing-masing terdapat 20 kasus gawat janin dan berat badan bayi lahir rendah. Penelitian tersebut juga menyebutkan bahwa dari 256 kelahiran, terdapat dua kasus kematian bayi serta empat bayi dinyatakan positif berdasarkan hasil tes PCR (Elshafeey et al., 2020).Tujuan penelitian ini untuk Mengetahui Hubungan antara ibu bersalin terkonfirmasi positif covid-19 dengan kejadian Asfiksia Bayi Baru Lahir di RSUD Labuang Baji Makassar. Metode penelitian ini adalah penelitian deskriptif Analitik dengan pendekatan Cross Sectional. Populasi dalam penelitian ini adalah seluruh ibu bersalin di RSUD Labuang Baji Kota Makassar.Hasil penelitian Menggambarkan bahwa dari 60 jumlah ibu bersalin dan telah melakukan tes usap Covid-19 terdapat 30 ibu yang terkonfirmasi positif Covid-19 dan 30 yang terkonfirmasi negative Covid-19, terdapat 18 orang (30%) BBL yang mengalami asfiksia dan 42 (70%) yang tidak mengalami asfiksia. Kesimpulan Tidak ada hubungan antara ibu bersalin terkonfirmasi Positif Covid-19 dengan kejadian Asfiksia pada BBL di RSUD Labuang Baji Kota Makasssar.
Diharapkan kepada tempat penelitian yaitu RSUD Labuang Baji agar meningkatkan pelayanan pada kasus persalinan dengan positif Covid-19 serta penanganan Asfiksia pada BBL.
Analisis Budaya Kaizen Terhadap Kinerja Bongkar Muat Kapal Di Perusahaan Pelayaran PT. Tanto Intim Line Pelayaran Nusantara
Authors: Retno Sawitri Wulandari  , Suhartini  , Hutagaol Meilinasari Nurhasanah 
Published: October 2023

Rendahnya kinerja karyawan PT. Tanto Line Pelayaran Nusantara tercermin dari hasil kuantitas dan kualitas pekerjaan yang belum sesuai dengan target perusahaan. Untuk itu tim peneliti bertujuan mengangkat penelitian ini untuk menganalisis budaya organisasi yang lebih terarah pada budaya kaizen terhadap kinerja penanganan bongkar muat kapal di perusahaan pelayaran PT. Tanto Line Pelayaran Nusantara. Adapun metode penelitian yang digunakan tim peneliti adalah metode deskriptif kuantitatif. Jumlah populasi dan jumlah sampel adalah 30 responden ,teknik pengambilan sampel adalah sampling jenuh. Hasil penelitian dan pembahasan diperoleh bahwa budaya kaizen berpengaruh positif dan signifikan terhadap kinerja penanganan bongkar muat kapal di perusahaan pelayaran PT. Tanto Intim Line Pelayaran Nusantara
Analisis Pengaruh Literasi Keuangan terhadap Kesejahteraan Suplier Teri Nasi di Desa Dungkek Kabupaten Sumenep
Authors: Hakim Rachman , Furqon Mohammad Amir , Gazali Gazali , Farid Farid 
Published: October 2023

Dungkek Village is an area with very abundant potential for anchovies. However, so far, fishermen and suppliers of anchovies have often experienced problems with capital. Using quantitative research, this research will measure the level of financial literacy and its impact on the welfare of anchovy suppliers in Dungkek Village, Sumenep Regency. The total research sample (sample size) was 42 research respondents. This research will be carried out in 2022 in Dungkek Village, Sumenep Regency. Education level, financial literacy, and work experience will be independent variables. Meanwhile, the welfare of rice anchovy suppliers is used as the dependent variable. Multiple linear regression analysis will be used to determine the influence of work experience, education level, and financial literacy on the welfare of anchovy suppliers based on a recapitulation of questionnaire answers obtained from respondents. Based on the research results, the level of work experience has the most dominant influence in improving supplier welfare. Meanwhile, the level of education and financial literacy also have a big influence. The effect of financial literacy is significantly positive on the welfare of rice anchovy suppliers. Higher financial literacy can improve the welfare of rice anchovy suppliers.
Role of Women Farmers Group on Agriculture Development in Jeruksawit Village
Authors: Antriyandarti Ernoiz , Damayanti Alvina , Setyaningrum Annisa , Kurniawati Atila Windi , Nur Deandra Suci , Khairunnisa Dian Ayu , Pangesti Anggityas Werdining , Aggraini Desta Prasanthi 
Published: October 2023

Agriculture development requires the role of many institutions. Achieving agricultural development is needed to develop economics. At the regional level, agriculture is one of the primary sources of livelihood. We need to solve problems in agriculture to achieve agricultural development. One institution that will be observed in this study is the women farmers group, their role in solving agricultural issues, and agriculture development strategy in the village. This study analyzes women farmers' role in agriculture development strategy in Jeruksawit Village, Gondangrejo, Karanganyar, Central Java. The primary research method used in this study is descriptive with an explanatory research approach. The location was chosen in Jeruksawit Village, Gondangrejo, Karanganyar, Central Java. The study was carried out from November to December 2021. The place was chosen because there is a women farmers group and some problems with agricultural developments. The data used are primary and secondary. The preliminary data were collected through in-depth interviews, field observation, and triangulation. To assess information for primary data, this study uses key informants as the information source. The secondary data were collected from Central Bureau Statistics Central Java, literature review, and farmers group archives. The analysis method used is the analysis of Miles and Huberman, which is carried out through data reduction, display of data collection, and verification. The results of this study show that the women farmers group plays an essential role in agriculture development by training farmers to increase farmers' education, doing comparative studies to understand agriculture better, providing partnerships between farmers, and providing agriculture counseling.
تأثير منهج تدريبي في تطوير تحمل السرعة لحكام الدوري العراقي الممتاز لكرة القدم
Authors: عبد الكريم مصطفى , قاسم صباح 
Published: October 2023

مستخلص البحث
أن سرعة الأداء اصبحت واحدة من أهم متطلبات كرة القدم الحديثة مع الاخذ بنظر الاعتبار المساحة الكبيرة لميدان اللعب الخاص بها، ولكي يتمكن حكم كرة القدم الذي يعد واحد من ركائز هذه اللعبة من قيادة المباراة بنجاح وجب عليه أن يتمتع باللياقة البدنية العالية والتي تمكنه ايضا من اجتياز الاختبارات البدنية التي يخضع لها خلال الموسم الرياضي وكذلك الاداء العالي أثناء المباراة.
وتبرز أهمية البحث من خلال اعداد منهج تدريبي لتطوير الاداء البدني لحكام الدوري العراقي الممتاز لكرة القدم (حكام ساحة) خلال فترة المنافسات.
وتمحورت المشكلة للدراسة في أن معظم الحكام لديهم مشكلة في الاعداد للاختبارات البدنية خلال فترة التوقف بين المرحلة الاولى والثانية من الدوري (الذهاب والاياب) ، وأغلب الحكام يتدربون طوال الموسم الكروي على مضمار الركض الخاص بألعاب القوى والابتعاد عن المحك الحقيقي للحكم وهو ميدان اللعب لذا ان تطبيق اختبارات ثانوية مقننة ومعتمدة من قبل الاتحاد الدولي لكرة القدم واستخدام ميدان اللعب للاختبار البدني سيساهم حتما في تغير طريقة التدريب خلال فترة المنافسات وتجنب الحالات السلبية التي ترافق هذه الفترة من ضغط بدني في التدريب وكثرة الاصابات لدى الحكام.
وهدف البحث إلى اعداد منهج تدريبي والتعرف على تأثير المنهج في اجتياز اختبارات الجاهزية لحكام الساحة للدوري العراقي الممتاز لكرة القدم.
واستخدم الباحثان المنهج التجريبي ذو المجموعة الواحدة لملاءمته طبيعة مشكلة الدراسة واختاروا عينة البحث من حكام الساحة للدوري الممتاز الدرجة الاولى في محافظة بغداد وعددهم (15) حكم مثلوا 50% من مجتمع البحث، وأجريت الاختبارات الخاصة عليهم في ملاعب وزارة الشباب والرياضة / بغداد ، وبعد تحليل ومناقشة النتائج توصل الباحثان الى وجود فروق معنوية بين الاختبارات القبلية والبعدية ولصالح الاختبارات البعدية لمجموعة البحث بسبب المنهج المستخدم