bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐Frequency Ultrasound Sensitive Piezo1 Channels Regulate Keloid‐Related Characteristics of Fibroblasts
Authors: Jiang Zixi , Chen Ziyan , Xu Yantao , Li Hui , Li Yixin , Peng Lanyuan , Shan Han , Liu Xin , Wu Huayi , Wu Lisha , Jian Dan , Su Juan , Chen Xiang , Chen Zeyu , Zhao Shuang 
Published: February 2024

AbstractKeloids are benign fibroproliferative tumors that severely diminish the quality of life due to discomfort, dysfunction, and disfigurement. Recently, ultrasound technology as a noninvasive adjuvant therapy is developed to optimize treatment protocols. However, the biophysical mechanisms have not yet been fully elucidated. Here, it is proposed that piezo‐type mechanosensitive ion channel component 1 (Piezo1) plays an important role in low‐frequency sonophoresis (LFS) induced mechanical transduction pathways that trigger downstream cellular signaling processes. It is demonstrated that patient‐derived primary keloid fibroblasts (PKF), NIH 3T3, and HFF‐1 cell migration are inhibited, and PKF apoptosis is significantly increased by LFS stimulation. And the effects of LFS is diminished by the application of GsMTx‐4, the selective inhibitor of Piezo1, and the knockdown of Piezo1. More importantly, the effects of LFS can be imitated by Yoda1, an agonist of Piezo1 channels. Establishing a patient‐derived xenograft keloid implantation mouse model further verified these results, as LFS significantly decreased the volume and weight of the keloids. Moreover, blocking the Piezo1 channel impaired the effectiveness of LFS treatment. These results suggest that LFS inhibits the malignant characteristics of keloids by activating the Piezo1 channel, thus providing a theoretical basis for improving the clinical treatment of keloids.
Mfn2/Hsc70 Complex Mediates the Formation of Mitochondria‐Lipid Droplets Membrane Contact and Regulates Myocardial Lipid Metabolism
Authors: Hu Lang , Tang Daishi , Qi Bingchao , Guo Dong , Wang Ying , Geng Jing , Zhang Xiaoliang , Song Liqiang , Chang Pan , Chen Wensheng , Fu Feng , Li Yan 
Published: February 2024

AbstractThe heart primarily derives its energy through lipid oxidation. In cardiomyocytes, lipids are stored in lipid droplets (LDs) and are utilized in mitochondria, although the structural and functional connections between these two organelles remain largely unknown. In this study, visible evidence have presented indicating that a complex is formed at the mitochondria‐LD membrane contact (MLC) site, involving mitochondrion‐localized Mfn2 and LD‐localized Hsc70. This complex serves to tether mitochondria to LDs, facilitating the transfer of fatty acids (FAs) from LDs to mitochondria for β‐oxidation. Reduction of Mfn2 induced by lipid overload inhibits MLC, hinders FA transfer, and results in lipid accumulation. Restoring Mfn2 reinstates MLC, alleviating myocardial lipotoxicity under lipid overload conditions both in‐vivo and in‐vitro. Additionally, prolonged lipid overload induces Mfn2 degradation through the ubiquitin‐proteasome pathway, following Mfn2 acetylation at the K243 site. This leads to the transition from adaptive lipid utilization to maladaptive lipotoxicity. The experimental findings are supported by clinical data from patients with obesity and age‐matched non‐obese individuals. These translational results make a significant contribution to the molecular understanding of MLC in the heart, and offer new insights into its role in myocardial lipotoxicity.
Revealing the Lattice Carbonate Mediated Mechanism in Cu2(OH)2CO3 for Electrocatalytic Reduction of CO2 to C2H4
Authors: Gao Yugang , Xiao Difei , Wang Zeyan , Zheng Zhaoke , Wang Peng , Cheng Hefeng , Liu Yuanyuan , Dai Ying , Huang Baibiao 
Published: February 2024

AbstractUnderstanding the CO2 transformation mechanism on materials is essential for the design of efficient electrocatalysts for CO2 reduction. In aconventional adsorbate evolution mechanism (AEM), the catalysts encounter multiple high‐energy barrier steps, especially CO2 activation, limiting the activity and selectivity. Here, lattice carbonate from Cu2(OH)2CO3 is revealed to be a mediator between CO2 molecules and catalyst during CO2 electroreduction by a 13C isotope labeling method, which can bypass the high energy barrier of CO2 activation and strongly enhance the performance. With the lattice carbonate mediated mechanism (LCMM), the Cu2(OH)2CO3 electrode exhibited ten‐fold faradaic efficiency and 15‐fold current density for ethylene production than the Cu2O electrode with AEM at a low overpotential. Theoretical calculations and in situ Raman spectroscopy results show that symmetric vibration of carbonate is precisely enhanced on the catalyst surface with LCMM, leading to faster electron transfer, and lower energy barriers of CO2 activation and carbon–carbon coupling. This work provides a route to develop efficient electrocatalysts for CO2 reduction based on lattice‐mediated mechanism.
Can corporate environmental, social, and governance performance influence foreign institutional investors to hold shares? Evidence from China
Authors: Feng Juzhang , Tang Sha , Zhong Junhao 
Published: February 2024

AbstractWith the rise of environmental, social, and governance (ESG) investment concepts, foreign institutional investors have become increasingly concerned about corporate ESG performance. Based on data of China's A‐share listed companies from 2011 to 2021, we empirically find that corporate ESG performance enhances foreign institutional investors to hold shares. Economic policy uncertainty significantly reduces the impact of corporate ESG performance on foreign institutional investors' shareholdings. The mechanism analyses show that information asymmetry and corporate reputation are the two transmission channels for corporate ESG performance that influence foreign institutional investors to hold shares. Further analysis shows that companies with good ESG performance are prone to become heavy investments and long‐term shareholdings for foreign institutional investors. The heterogeneity analyses show that the effect of ESG performance on foreign institutional investors' shareholdings is more significant among firms that are not state‐owned, with high business risk and in heavily polluting industries.
Genomic heterogeneity of multiple synchronous lung cancers in Chinese population
Authors: Zhao Lei , Wang Jin , Zhang Yixiang , Wang Peng , Lv Changsheng , Zhao Shilei , Guo Tao , Li Fengzhou , Gu Chundong , Zhu Yuntao 
Published: February 2024

AbstractIntroductionIt is clinically challenging to infer the phylogenetic relationship between different tumor lesions of patients with multiple synchronous lung cancers (MSLC), whether these lesions are the result of independently evolved tumor or intrapulmonary metastases.MethodsWe used the Illumina X10 platform to sequence 128 stage I lung cancer samples collected from 64 patients with MSLC. All samples were analyzed for mutation spectra and phylogenetic inference.ResultsWe detected genetic aberrations within genes previously reported to be recurrently altered in lung adenocarcinoma including, EGFR, ERBB2, TP53, BRAF, and KRAS. Other putative driver mutations identified were enriched in RTK‐RAS signaling, TP53 signaling, and cell cycle. Also, we found some interesting cases, two cases that carried EGFR L858R and T790M co‐mutation in one tumor and another tumor with only EGFR 19del, and 1 case with two KRAS hotspots in the same tumor. Due to the short follow‐up time and early stage, further investigation is needed to determine whether this unique mutation profile will affect their progression‐free survival (PFS) and overall survival (OS). Regarding genetic evolution analysis among 64 tumor samples, 50 of them display distinct mutational profiles, suggesting these are independently evolved tumors, which is consistent with histopathological assessment. On the other hand, six patients were identified to be intrapulmonary metastasis as the mutations harbored in different lesions are clonally related.ConclusionIn summary, unlike intrapulmonary metastases, patients with MSLC harbor distinct genomic profiles in different tumor lesions, and we could distinguish MSLC from intrapulmonary metastases via clonality estimation.
Hearing preservation after stereotactic radiosurgery for sporadic intracanalicular vestibular schwannomas classified as Koos grade 1
Authors: Kang Ho , Ji So Young , Kim Chae‐Yong , Koo Ja‐Won , Song Jae‐Jin , Choi Byung Yoon , Hwang Kihwan , Han Jung Ho 
Published: February 2024

AbstractIntroductionThe mechanism of hearing loss following stereotactic radiosurgery (SRS) for vestibular schwannomas (VSs) remains unclear. There is conflicting evidence regarding cochlear nerve damage by transient volume expansion of VSs after radiosurgery and radiation‐induced cochlear damage. This study aimed to investigate whether there is a specific patient population that can achieve definite hearing preservation after SRS for VSs.MethodsA total of 37 consecutive patients with sporadic unilateral intracanalicular VSs and serviceable hearing (Gardner‐Roberson [G‐R] class I or II) were treated with SRS from 2009 to 2023. This is a retrospective study. Survival analysis with Cox regression for hearing deterioration was performed.ResultsThe median age was 55 years old. The median tumor volume was 0.089 cm3, and the median marginal dose was 12.0 Gy. Nonserviceable hearing deterioration occurred in 9 patients (24.3%), with a median onset of 11.9 months after SRS. The actuarial rates of serviceable hearing preservation were 86%, 82%, and 70% at 1, 2, and 3 years after SRS, respectively. In a multivariate analysis, only baseline pure tone average > 30 dB increased the risk of nonserviceable hearing deterioration with significant hazard ratio. There were 13 patients with petit VSs whose tumor volume was smaller than 0.05 cm3, and 11 of them were treated by a 4‐mm single shot with a marginal dose of 12 Gy. None of the 13 patients had nonserviceable hearing deterioration.ConclusionsPetit VSs that can be treated with 4‐mm single or double shots with a marginal dose of 12 Gy may achieve hearing preservation after SRS.
Patient's experiences of coughing after lung cancer surgery: A multicenter qualitative study
Authors: Zhou Xiangxi , Lei Cheng , Wei Xing , Dai Wei , Xu Wei , Ao Yongping , Li Xianglin , Qiao Guibin , Shi Qiuling 
Published: February 2024

AbstractPurposeCough is one of the most common symptoms after lung cancer surgery, which seriously affects the quality of life. Little research has been conducted on patient's experiences of cough following lung surgery. This study aimed to elucidate the experience of coughing after lung cancer surgery from the patient's perspective regarding symptoms and their impacts on daily life, as well as triggers and dealing strategies.MethodsBetween June 2023 and July 2023, we conducted semi‐structured interviews with patients from outpatient clinics of two hospitals who were pathologically diagnosed with lung cancer and experienced cough after surgery through convenience sampling. The interview recordings were transcribed and analyzed by two researchers. The traditional content analysis and thematic analysis were used to identify the common codes, subthemes, and themes.ResultsA total of 28 participants were interviewed. The mean age of the participants was 55.21 years (range: 36–75 years), and 21 participants were female. Most patients (75%) were interviewed within 6 months of surgery. We identified five themes (accompanying symptoms, incentives, effects, solution, and information sources) and 12 subthemes (local symptoms, systemic symptoms, personal factors, external factors, emotion, relationship with others, reduced quality of life, medical measures, nonmedical measures, no measures, relatives and friends, and the Internet). Patients with lung cancer may experience various cough symptoms after surgery, which a variety of internal and external factors can trigger. The coughing imposes a double burden on the physical and psychological due to the negative emotions it provokes.ConclusionWe generated a concept framework of cough after lung cancer surgery, providing a basis for further development of measurement tools from the patients' perspective. The lack of knowledge related to coughing highlights the need for adequate and timely health education and professional medical care.
Reversible Dihydrogen Activation and Catalytic Transfer Hydrogenation with Iminophosphinoyl‐Tethered Ruthenium Carbene Complexes
Authors: Hensle Lennart , Feichtner Kai‐Stephan , Kleinhaus Michelle , Heinen Tobias , Boysen Nils , Papp Florian , Gessner Viktoria H. 
Published: February 2024

AbstractIn the last decades, metal ligand cooperativity has intensively been used as tool in homogeneous catalysis for the development of potent catalysts for a variety of applications, above all hydrogenation and transfer hydrogenation reactions. Herein, we report on the synthesis of iminophosphinoyl‐tethered ruthenium carbene complexes and their use in the activation of dihydrogen and the catalytic transfer hydrogenation of p‐fluoroacetophenone. Variation of the N‐substituent to an electron‐withdrawing p‐nitrophenyl group enabled the reversible activation of elemental hydrogen via a 1,2‐addition across the metal carbon double bond both in solution and in solid state. In comparison to the thiophosphinoyl‐tethered carbene complex the presented iminophosphinoyl systems showed a considerably increased catalytic activity in transfer hydrogenation reactions, thus highlighting the tunability of the cooperative behavior of nucleophilic carbene complexes.
Cobalt‐Catalyzed Hydrosilylation across Carbon‐Carbon, Carbon‐Oxygen, and Carbon‐Nitrogen Multiple Bonds – A Comprehensive Review
Authors: Jose Jisna , Mathew Thomas V. 
Published: February 2024

AbstractThe selective conversion of unsaturated compounds has emerged as a crucial method in chemical synthesis, enabling the synthesis of functional organic molecules. In recent decades, transition metal‐catalyzed hydrosilylation has emerged as a highly successful exemplar of industrialization within the realm of organic chemistry for the production of organosilanes, which have a pivotal role in organic chemistry and materials science. Precious metal complexes are typically employed as catalysts in most industrial hydrosilylation processes. The exploration of Earth‐abundant alternatives has emerged as a focal point of considerable research attention due to the high cost, poor selectivity, and many side reactions reported for precious metal catalysts. Ligand skeleton construction, selectivity, and mechanism research are areas where cobalt catalysts have more potential than iron and nickel. This review discusses the recent advances in cobalt‐catalyzed hydrosilylation across carbon‐carbon, carbon‐oxygen, and carbon‐nitrogen multiple bonds from 2019 to 2023.
Enzymatic and Chemo–catalytic Redox Deracemization: Recent Progress
Authors: Wan Qian , Wang Zehua , Sun Huairi , Song Di , Wang Xiaojing , Liu Lei 
Published: February 2024

AbstractThe precise synthesis of chiral small molecules is a core research area in chemical science. Deracemization, an appealing technology that converts racemate to its single enantiomer with the same constitution in theoretical 100 % yield, appears as a straightforward and efficient strategy in asymmetric synthesis. A cascading redox sequence was the most employed approach to drive deracemization through destroy and recreate the stereocenter in a given molecule. This review mainly focuses on the progress of redox deracemization driven by respective biocatalysis and chemo–catalysis. In particular, each section will be subdivided according to the action modes, the respective substrate classes and perspectives on future development.
Quality of randomized controlled trials and systematic reviews in pediatric surgery: A cross‐sectional meta‐research study
Authors: Jiang Wilson , Wang Bill , Sperandei Sandro , Tan Aidan Christopher 
Published: February 2024

AbstractBackgroundThere are few randomized controlled trials (RCTs) in pediatric surgery, and their risk of bias is unknown. There is also little known about the methodological or reporting quality of systematic reviews (with or without meta‐analyses) in pediatric surgery. Therefore, we conducted a cross‐sectional meta‐research study to determine the risk of bias and reporting quality of RCTs and systematic reviews and meta‐analyses in pediatric surgery, and the associations between these outcomes and study characteristics.MethodsWe searched MEDLINE, Embase, Cochrane Library, JBI EBP Database, Centre for Reviews and Dissemination and Web of Science for all RCTs and systematic reviews in pediatric surgery published in 2021. We also searched the 2021 indexes of high‐impact pediatric surgery journals. We assessed the risk of bias and reporting quality of RCTs using the RoB 2 and CONSORT tools respectively. We assessed the same parameters for systematic reviews and meta‐analyses using the ROBIS and Preferred Reporting Items for Systematic Reviews and Meta‐analyses tools.FindingsWe found 82 RCTs and 289 systematic reviews/meta‐analyses published in 2021. More than half (n = 46, 56%) of RCTs and almost all (n = 278, 96%) systematic reviews and meta‐analyses were at high risk of bias. Only one (1%) RCT and four (1%) systematic reviews and meta‐analyses were adequately reported. Less than half (n = 40, 49%) of RCTs and just over a quarter (n = 77, 27%) of systematic reviews and meta‐analyses had a registered protocol. Surprisingly, we found that more than half of systematic reviews and meta‐analyse (n = 162, 56.1%), had no risk of bias assessment.ConclusionsRecently published RCTs and systematic reviews in pediatric surgery are at high risk of bias and have poor reporting quality. Journals, universities, and research institutions should train authors to conduct and report higher quality studies and develop strategies to reduce risk of bias. However, research with high bias and low reporting does not necessarily lack value.
Molecular Dynamics of Steroidal Rotors Probed by Theoretical, Spectroscopic and Dielectric Methods
Authors: Olszewska Karolina , Mizera Adam , Ławniczak Paweł , Kamińska Anna , Santillan Rosa , Morales‐Chamorro Maricela , Ochoa Ma. Eugenia , Farfán Norberto , Łapiński Andrzej , Górecki Marcin , Jastrzebska Izabella , Runka Tomasz 
Published: February 2024

AbstractOur study focuses on molecular rotors with fast‐moving rotators and their potential applications in the development of new amphidynamic crystals. Steroidal molecular rotors with a dipolar fluorine‐substituted phenyl group as the rotator were synthesized and characterized. Three different rotors were investigated with varying numbers of fluorine atoms. A comprehensive analysis was performed using vibrational spectroscopy (Raman, FT‐IR), electronic circular dichroism (ECD), and dielectric response to understand the behavior of the investigated model rotors. The results were supported by theoretical calculations using Density Functional Theory (DFT) methods. The angle‐dependent polarized Raman spectra confirmed the crystallinity of the samples. Nearly frequency and temperature‐independent permittivity suggest low‐frequency librational motion of stators. An in‐depth analysis of ECD spectra revealed high conformational flexibility in solution, resulting in low ECD effects, while in the solid‐state with restricted rotation, significant ECD effects were observed. These findings shed light on the conformational behavior and potential applications of the studied steroidal molecular rotors.
Dansylated Nitrile N‐Oxide as the Fluorescent Dye Clickable to Unsaturated Bonds without Catalyst
Authors: Oku Yuki , Nakajima Noriyuki , Hamada Masahiro , Koyama Yasuhito 
Published: February 2024

AbstractFluorescent polymeric materials have been exploited in the fields of aesthetical purposes, biomedical engineering, and three‐dimensional printing applications. While the fluorescent materials are prepared by the polymerization of fluorescent monomer or the blending a fluorescent dye with common polymer, the covalent immobilization of fluorescent dye onto common polymers is not the practical technique. In this paper, dansylated nitrile N‐oxide (Dansyl‐NO) has been designed and synthesized to be a stable nitrile N‐oxide as the derivative of 2‐hydroxy‐1‐naphthaldehyde. While Dansyl‐NO shows good reactivity to an alkene and an alkyne to give fluorescent Dansyl‐Ene and Dansyl‐Yne, respectively, it hardly reacts to a nitrile. The results indicate that Dansyl‐NO serves as a fluorescent dye clickable to alkenes and alkynes. To know the effects of solvent on the fluorescent properties, the UV‐vis and fluorescence spectra of Dansyl‐Ene are measured in three solvents. Dansyl‐Ene shows fluorescent solvatochromism, which appears to be red‐shifted along with the increase in solvent polarity. Poly(styrene‐co‐butadiene) directly reacts with Dansyl‐NO to give fluorescent modified SB. The emission spectrum of modified SB is blue‐shifted compared with that of Dansyl‐Ene. The blue‐shift could be possibly attributed to the presence of less polar polymer skeleton around the dansyl moieties of modified SB.
A novel soft sensing method using intelligent modeling method for solar irradiance and temperature in distributed PV power plant
Authors: Zhu Honglu , Jiang Tingting , Zhou Hai , Sun Yahui , Ma Wenwen , Zhang Xi 
Published: February 2024

AbstractDistributed photovoltaic (PV) power plants often lack solar irradiance monitoring devices, significantly hindering crucial functions such as power forecasting, fault diagnosis, and performance calculation for distributed PV. To address this issue, a real‐time method for soft sensing solar irradiance was proposed in distributed PV. First, we investigated the typical relationship between solar irradiance, ambient temperature, and the electrical characteristics of PV cells. Based on this relationship, we utilized the small sample modeling technique of the Genetic Algorithm‐Support Vector Machine to calculate the ambient temperature. Subsequently, a solar irradiance calculation model based on the backpropagation neural network was developed, taking the PV array voltage, current, calculated ambient temperature, and power as inputs. This approach enables for the estimation of solar irradiance in distributed PV power plants through a simple and efficient calculation process. To demonstrate the reliability and flexibility of the algorithm, we conducted testing with data under various input conditions, such as different power plant configurations, and seasons, coefficient of determination for the proposed model reached 0.95. Overall, the novelty of the proposed method offers a practical solution for soft sensing of solar irradiance in PV power plants, enabling accurate performance analysis and effective operation management without hardware investment.
How culture and legal environment affect classification shifting? Global evidence
Authors: Boahen Eric O. , Mamatzakis Emmanuel C. 
Published: February 2024

AbstractThis study examines the interplay between various cultural characteristics and the legal environment on classification shifting using a global sample that enables variability in underlying cultural characteristics across countries while controlling for heterogeneity. Given that both culture and the legal environment tend to exhibit low variability over time, our international cross‐country analysis with diverse cultural dimensions and legal frameworks enhances the robustness of our empirical findings. Our identification strategy employs several models and shows the significant impact of culture on classification shifting and the interactions between national culture and the legal environment on classification shifting behaviour, though there is variability across countries. We also find that certain traits of culture induce classification shifting. We highlight that strengthening the legal environment becomes crucial in creating an institutional framework that effectively curbs unethical practices induced by certain national culture traits and enhances transparency and accountability in financial reporting.