bluuebunny/crossref_metadata_2025_split huggingface dataset:
When is surgical intervention needed in oral and maxillofacial space infection patients? A retrospective case control study in 46 patients
Authors: Liu Yimin , Zhu Hanyi , Qin Yingyi , He Zhiyuan , Zheng Lingyan , Shi Huan 
Published: November 2023

Abstract

Objective:
Patients with mild oral and maxillofacial space infection (OMSI) usually need only antimicrobial therapy. However, surgical intervention is eventually needed after using antibiotics for a period. The objective of this study was to explore the risk factors for drug therapy failure in OMSI.
Subjects and methods:
A retrospective case‒control study was designed. From August 2020 to September 2022, patients at Shanghai Jiao Tong University Affiliated Ninth People's Hospital who were diagnosed with OMSI were retrospectively reviewed. The outcome variable was surgical intervention after the use of antibiotics. We collected common biological factors, including demographic characteristics, routine blood test results, C-reactive protein (CRP) levels and composite indicators, such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). The χ2 test and binary logistic regression were used to examine the association between biological factors and the outcome variable.
Results:
Forty-six patients were included in this study. Further surgical intervention was needed in 20 patients (43.5%). The NLR showed a significant association with further surgical drainage (p=0.01). A binary logistic regression equation was found by using stepwise regression based on the Akaike information criterion (R2=0.443), which was associated with sex (odds ratio [OR], 0.216; p=0.092), NLR (OR, 1.258; p=0.045), red blood cell (RBC) count (OR, 4.372; p=0.103) and monocyte (MONO) count (OR, 9.528, p=0.023). Receiver operating characteristic analysis produced an area under the curve for NLR of 0.725 (p=0.01) and for the binary logistic regression model of 0.8365 (p<0.001).
Conclusion:
Surgical interventions are needed in some mild OMSI patients when antimicrobial therapy fails to stop the formation of abscesses. The binary logistic regression model shows that NLR can be used as an ideal prognostic factor to predict the outcome of antimicrobial therapy and the possibility of requiring surgical intervention.
Statement of clinical relevance:
Using simple, inexpensive, and easily achieved biological parameters (such as routine blood test results) and composite indicators calculated by them (such as NLR) to predict whether surgical intervention is needed in the future provides a reference for clinical doctors and enables more cost-effective and efficient diagnosis and treatment.
Primary Thyroid Lymphoma: A Nationwide Retrospective Cohort Analysis of Survival and Determinant Factors
Authors: Koseoglu Fatos Dilan , GUNES Ajda , KAYA Sureyya YIGIT , SEVINDIK Omur Gokmen , CETINTEPE Tugba , BULBUL Hale , MENGUC Meral ULUKOYLU , YILMAZ Asu Fergun , KUCUKYURT Selin , GUNES Ahmet Kursad , YILMAZ Seda , KUREKCI Derya Deniz , ILTAR Utku , ULUSOY Yusuf , UYSAL Ayse , TOMBAK Anil , AYKAS Fatma , KARAKUS Volkan , SAYDAM Guray 
Published: November 2023

Abstract
Purpose
This study aims to analyze survival rates and determinant factors in patients diagnosed with primary thyroid lymphoma, a rare subtype of thyroid cancer.
Methods
We conducted a retrospective analysis of 57 primary thyroid lymphoma cases from fourteen tertiary care hospitals over a span of 22 years. Patient demographics, clinical presentations, treatment regimens, and outcomes were reviewed. Survival analysis was performed using Kaplan-Meier and Cox regression models.
Results
The majority of patients were middle-aged and older women, with a mean age of 60. Diffuse large B-cell lymphoma was the predominant histological subtype. The median overall survival was 163 months, with a 5-year survival rate of 69.2%. Treatment primarily involved R-CHOP chemotherapy, with 81.1% achieving a complete response. Tracheal compression and age were identified as independent prognostic factors for survival.
Conclusion
Primary thyroid lymphoma predominantly affects older women and is commonly diagnosed as diffuse large B-cell lymphoma. The data suggest that age and tracheal compression significantly influence patient survival, emphasizing the importance of these factors in the management and prognosis of primary thyroid lymphoma.
Polymicrobial infective endocarditis in the setting of intravenous drug use
Authors: Drago Thomas , Bakhit Mohamed , Long Michael , DO Mrinalini Ramesh , MD/ John K Crane 
Published: November 2023

Abstract

Background: The pathogenesis of infective endocarditis (IE) involves the interaction of microorganisms such as bacteria or fungi with the endothelial lining of heart valves. Patients with IE typically have a pre-existing valvular defect that allows highly virulent organisms to attach to valve leaflets. In patients with a history of intravenous drug use (IVDU), a leaflet of the tricuspid valve is typically involved in the setting of bacteremia or fungemia as the right heart is the site of venous return. Recent data shows that 80-90% of IE cases are caused by microorganisms such as staphylococci or streptococci, but the isolation of more than one microorganism is only seen in around 1-6.8% of cases.
Case presentation: This is a 31-year-old Caucasian male with a past medical history of tobacco use, IVDU, major depressive disorder, generalized anxiety disorder, and chronic left lower extremity wound presenting to the emergency department (ED) with shortness of breath. Upon further investigation, patient was found to have polymicrobial IE growing both methicillin-sensitive staphylococcus aureus (MSSA) as well as group A streptococcus (GAS) pyogenes. He was diagnosed on transthoracic echo with pulmonary emboli seen on CT imaging. Patient received IV cefazolin where he was monitored on the medical floors for several weeks.
Conclusions: This case report is meant to highlight the importance of assessing for polymicrobial IE in patients at risk. Given the possible uncommon pathology behind a patient’s symptoms with different microorganisms, it is imperative to identify causative organisms early to administer proper therapeutic treatment. Using clinical judgment to repeat investigations when warranted in order to properly diagnose patients is important when clinical suspicion for disease is high. Understanding the variations of severity/treatment between monomicrobial versus polymicrobial IE can drastically change prognosis. Finally, acknowledging the difficulty of lengthy in-patient hospital therapies in patients unable/unwilling to stay is important in this patient population.
Real World Study of Cumulative Absolute Reduction in Axial Elongation (CARE) afterPhotobiomodulation Therapy
Authors: Zhou Lei , David Coveney , Li Ying , Tong Liyang , Qiu Kaikai 
Published: November 2023

Abstract
Purpose: To assess the age and timeline distribution of ocular axial length shortening among myopic children treated with photobiomodulation therapy.
Methods: Retrospective study of photobiomodulation therapy in Chinese children aged 4 to 13 years old where axial length measurements were recorded and assessed to determine effectiveness at each age level across two age groups. Data was collected from myopic children who received photobiomodulation therapy using the same device for 6~12 months. Effective myopia control was defined as any follow-up axial length < baseline axial length, confirming a reduction in axial length.
Results: 342 myopic children were included with mean age 8.64±2.20 years and baseline mean axial length of 24.41±1.17 mm. There were 85.40%, 46.30%, 71.20% and 58.30% children with axial length shortening recorded on follow-up at 1 month, 3 months, 6 months and 12 months, respectively. With respect to the axial length shortened eyes, the mean axial length difference (standard deviation) was -0.039 (0.11) mm, -0.032 (0.11) mm, -0.037 (0.12) mm, -0.028 (0.57) mm at 1, 3, 6, and 12-month follow-up, respectively. Greater AL shortening was observed among older children who had longer baseline axial lengths (P < 0.001).
Conclusions: Overall myopia control effectiveness using photobiomodulation therapy was shown to be age and time related, with the maximum absolute reduction in axial elongation being cumulative.
Trial Registration Number (TRN): ClinicalTrials.gov ID: NCT05957458. Date of registration: 2023-07-24
Geriatric Consultation of Frail Patients in Internal Medicine Service and its association with hospital mortality, hospital stay and Intensive Care Unit admission. An observational study.
Authors: Contreras Maria Fernanda , Torres Oscar , Cortes Raul , Reyes Luisa 
Published: November 2023

Abstract
Objective: The main objective is to describe the association between monodisciplinary management led by the attending physician without geriatric intervention and the involvement of geriatrics as consultants for frail patients over 65 years old admitted to the internal medicine service. This assessment is based on patient outcomes, inpatient length of stay, percentage of admissions to intensive care unit, and in-hospital mortality.
Methods and Analysis: A prospective observational study was conducted in which all fragile patients over 65 years old admitted to internal medicine ward from March to November 2022 in two hospitals in northern Mexico were included. The outcomes were compared between the group of patients who received routine monodisciplinary management by their attending physician during hospitalization without the participation of a geriatrician, and those who had collaborative management with geriatrics as consultant. No interventions or suggestions were made to any of the groups assessed. Frailty stratification was performed on patients with the FRAIL scale.
Results: A total of 111 patients were included with a mean age of 80.6 ± 7.9 years. Out of the total patients, 60 (54.1%) received management from their treating physician along with a geriatrician as a consultant, and the remaining 51 only received monodisciplinary management from their treating physician. There was an association between monodisciplinary management and longer in-hospital stay, compared to the patients who received medical management along with Geriatrics (13.4 vs 5.8 days, P=<0.0001). 29% had a prolonged in-hospital stay, defined as longer than 9 days, and 84.8% of them had monodisciplinary management without Geriatrics consultation (84.8% vs 15.2%, P=<0.005). Of the patients under study, 17.1% died during hospitalization. The mortality in patients consulted by geriatrics was lower, however this association was not statistically significant (47.4% vs 52.6%, P=0.521).
Conclusion: The support of the geriatric physician in the in-hospital medical management of the frail elderly patient is significantly associated with a reduction in the length of in-hospital stay and rate of critical care unit admissions. It was not significantly associated with lower mortality; however this could be explained by the inherent nature of frailty as an unfavorable prognostic factor.
Contributions of ADAM12 via HB-EGF/EGFR signaling cascades to EMT and cancer progression in pancreas
Authors: Zhang Qiubo , Xu Feng , Gao Zetian , Dong Xianwen , Ma Yanyan , Li Hong , Huang Kaihong 
Published: November 2023

Abstract

Background
Pancreatic cancer (PC) is one of the most malignant tumors with a 5-year survival rate of less than 7% in China. High amount of stroma and activation of epithelial-mesenchymal transition (EMT) in PC induce drug resistance and poor prognosis.
Aims
The objective of the present study was to prove impaction of a disintegrin and metalloproteinase 12 (ADAM12) via Heparin-binding EGF-like growth factor (HB-EGF)/EGFR signalling pathway on EMT and cancer development in PC.
Methods
62 pancreatic specimens were collected from two hospitals by surgical resection, of which 43 were tumor specimens. All samples were analysed by immunohistochemistry.
Results
Consistent with GEPIA database, the expression of ADAM12, as well as HB-EGF, was significantly upregulated in 43 PC tissues compared with other 19 benign pancreatic mass. We also found that high expressions of ADAM12 and HB-EGF were significantly correlated with lymph node metastasis, advanced TNM stage and poor survival. Besides, high expression of ADAM12 was correlated with the upregulation of EGFR and EMT markers.
Conclusion
Together our data demonstrate that ADAM12 is associated with PC progression and may contribute to shedding of HB-EGF, inducing EMT through EGFR pathway. These suggest that inhibition of ADAM12/HB-EGF/EGFR signal pathway may be capable to be a therapeutic method, which requires further in vivo and vitro studies to explore the mechanism.
Cutaneous Chromoblastomycosis
Authors: Abza Fantahun , Babeta Fantahun Abza 
Published: November 2023

Abstract
Chromoblastomycosis is a chronic fungal infection that is caused by pigmented fungi which are commonly seen in the tropical and subtropical climates. This infection is thought to be secondary to trauma or autoinoculation. An etiological agent is a small group of dematiaceous (pigmented) fungi. At least five species of fungi have been recognized to cause chromoblastomycosis: Cladosporium carrionii, Fonsecaea compacta, Fonsecaea pedrosoi, Phialophora verrucosa, and Rhinocladiella aquaspersa. Here, A case of A 38-year-old man, who is a farmer from Ethiopia, presented with slowly spreading lesions which started from the right hand and spread diffusely to involve all the right arm, around 6 yrs duration.. Histopathology of the lesions confirmed cutaneous chromoblastomycosis.
Architecture of biohybrid organosilicon materials using various structure-controlling agents
Authors: Lantsova Elizaveta A. , Rybochkin Pavel V. , Saverina Evgeniya , Kamanina Olga A. 
Published: November 2023

Abstract
The article describes the immobilization of yeast cells Ogataea polymorpha VKM Y-2559 into organosilicon matrices based on tetraethoxysilane and dimethyldiethoxysilane using polyethylene glycol, polyvinyl alcohol and chitosan as structure-controlling agents. The influence of the structure-control agent on the time of formation of the sol-gel capsule around the cells and on the morphology of the hybrid material was determined. The formation of organosilicon material was confirmed using IR spectroscopy. Using the method of energy-dispersive X-ray spectroscopy, it was proven for the first time that the structure-controlling agent is not incorporated into the structure of the organosilicon shell.
Long non-coding RNA HCP5 affects ferroptosis in lung adenocarcinoma cells through miR-17-5p/HOXA7 axis
Authors: Pan Qingyun , Tang Zige , Zheng Jiayu , Yan Lingxin , Liang Yuxian , Chen Quanfan 
Published: November 2023

Abstract

Background
Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer. Ferroptosis is considered as a new target for the treatment of LUAD. Therefore, based on the previous bioinformatics mining of the ceRNA (competitive endogenous RNA) network human leukocyte antigen complex P5 (HCP5)/miR-17-5p/ Homeobox A7 (HOXA7) related to ferroptosis in LUAD, in this study, we verified the relationship between HCP5/miR-17-5p/HOXA7 axis and ferroptosis by cell experiments.
Methods
The dual luciferase report evaluated the interaction of HCP5 with miR-17-5p and miR-17-5p with HOXA7. Cell counting kit-8 (CCK-8) assay and transwell assay were used to detect the survival rate and invasion and migration of A549 cells, respectively. The ferroptosis-associated ACSL4 and SLC7A11, migration - and invasion-associated MMP9, vimentin, and E-cadherin proteins and mRNA were evaluated by Western blotting (WB) as well as real-time fluorescent quantitative PCR (qRT-PCR). Fe2+ and MDA were analyzed with kits.
Results
Overexpression of HCP5 promotes growth, proliferation, invasion and migration of A549 cells by increasing HOXA7 expression through regulation of miR-17-5P. In addition, knockdown of HCP5 elevated miR-17-5p and thus inhibited HOXA7 expression to suppress ferroptosis as well as epithelial mesenchymal transition in A549 cells.
Conclusion
Our results suggest that HCP5/miR-17-5p/HOXA7 can affect ferroptosis as well as biological behavior of A549 cells. Therefore, they can be considered as prognostic biomarkers and possible therapeutic targets for predicting the prognosis of LUAD.
Health-related Quality of Life and Its Associated Factors among Gynecologic Cancer Patients in Oncology Centers in Northwest Ethiopia 2023: Structural Equation Modeling
Authors: Ayalew Mahider , Mamo Fantu , Derseh Lemma 
Published: November 2023

Abstract
Background
Gynecological cancer is a catch-all term for any cancer of the female reproductive system, which are the most frequently type of cancers diagnosed in the female population. It is becoming a serious health issue that affects patients' health-related quality of life. In Ethiopia, factors affecting the quality of life of gynecologic cancer patients is not well explored. Thus, this study aimed to assess health related quality of life (HRQoL) and its associated factors among gynecologic cancer patients attending in oncology centers in Northwest Ethiopia.
Methods
An institution-based cross-sectional study with a total sample size of 608 gynecologic cancer patients were employed. Data were collected by interview administered questionnaire, coded and entered into Epi Data version 4.6, and then exported to STATA version 17 for further analysis. Texts, Figures, and Tables were used to present descriptive result. Structural equation model analysis was employed to verify the relation among, exogenous and endogenous variables.
Result
The mean score of overall HRQoL was 41.62(± 7.22).The social functioning domain was the most affected domain with mean score of 22.01(±8.6) and cognitive functioning domain were the least affected domain with mean score of 77.85(±22.37). Marital status (single) had a direct (β= -0.5323, 95%CI (-0.990,-0.0740)) and indirect negative effect (β= -0.2317, 95%CI (-0.4438,-0.0195)) giving a negative total effect (β= -0.795, 95%CI (-1.192,-0.3981)) on global health domain of HRQoL Patients with old age had a better physical function(β = 0.028 (0.0216,0.0344)) and cognitive function (β = 0.0210, 95%CI(0.015, 0.026)) but worsening of the symptomatic domain (β=(0.0054, 95%CI(0.0029, 0.0078)).
Conclusion and Recommendation:
Patients with gynecologic cancer had poor quality of life in all domains of EORTC-QLQ30 and overall health-related quality of life except the cognitive domain. Socio-demographic factors, namely age, marital status, educational status, occupation status), disease and treatment related factors (stage of cancer, type of cancer and type of treatment received) were significantly associated factors with HRQoL of gynecologic cancer patients.
CG-rich trinucleotide two-repeats may be the long-sought recombination hotspot loci shared across primates and mouse
Authors: Ohadi Mina , Tajeddin Nahid , Bayat Hadi , Arabfard Masoud , Salesi Mahmood , Moghadam Masoumeh Goleijani , Maddi Ali , Khamse Safoura , Alizadeh Samira , Ohadi Hamid , Delbari Ahmad , Khorshid Hamid R Khorram 
Published: November 2023

Abstract
CG-rich trinucleotide short tandem repeats (STRs) are linked with human cognition and various neurodevelopmental, neurological, and movement disorders. However, the fundamental two-repeat units of these STRs remain unexplored. On a genome-wide scale, here we mapped the two-repeat units of all combinations of CG-rich trinucleotides in human. We found 81,118 colonies (distance between each unit <500 bp). Subsequently, we performed a comparative genomics study of several large and medium-sized colonies of significant occurrence based on Poisson distribution, in other primates and mouse. We discovered that some of those colonies were shared, with extensive dynamicity, as phylogenetically distant as in mouse. We detected pure units and units that were overlaps of those pure units across the colonies, indicative of unequal crossing over and recombination at those units. We provide example models of some of the potential evolutionary implications of the colonies, such as mechanisms for the emergence and propagation of non-coding RNAs, as well as a defense system against transposable elements, through recombination-coupled inactivating mutations and methylation. In conclusion, we report extensively dynamic trans-species colonies of CG-rich trinucleotide two-repeat units, and indication of crossing over and recombination at those units. Whereas the bulk of literature supports the hypothesis that recombination hotspots rarely (if at all) occur at the same locus between human and chimpanzee, here we propose that sharing such loci may extend beyond primates, and include mouse. Based on the ubiquity, abundance, significant occurrence, and envisioned events and mechanisms associated with the identified colonies, we predict the identified colonies of phenomenal biological and evolutionary consequences.
Bibliometric analysis of global research trends and hotspots on imaging of bladder cancer
Authors: Gong Zijian , Liu Zhixuan , Zhu Jianghua , Zhao Zhen , Qiu Jia , Ying Hongxin , Peng Yun , Ye Yinquan , Gong Lianggen 
Published: November 2023

Abstract
Purpose
To conduct a comprehensive bibliometric analysis of relevant literature on the imaging of BCa and elucidate global research hotspots and further trends in this field.
Methods
All relevant literature on the imaging of BCa published between January 1, 2000 and July 25, 2023 were retrieved from the Web of Science Core Collection. VOSviewer, Bibliometrix and Citespace were utilized for bibliometric analysis of publications, countries, authors, institutions, journals, references, and keywords. Microsoft Excel was used to draw relevant charts according to the number of publications.
Result
A total of 4033 articles were retrieved. The research in this field has been increasing consistently since 2000. The USA was the most productive country and most productive institutions were from the USA. Shariat SF was the most productive author with 34 articles and the author with the highest co-citations was Herr HW (418). A study by Siegel RL, published in Ca-Cancer J Clin in 2019, had the highest number of co-citations. Further analysis of the keyword analysis and timeline view revealed that “deep learning”, “MRI”, “VI-RADS”, “muscle-invasive bladder cancer”, “immu-notherapy”, and “lymphatic metastasis” were the most recent hotspots.
Conclusion
The USA occupies a critical position in this field. The research on imaging of BCa can be classified into two periods: the tumor detection period before 2011 and comprehensive evaluation before treatment decision from 2011 to date. It is anticipated that MRI and deep learning will be the re-search hotspots in this field in the future.