bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of SGLT-2 Inhibitors on Lipid Profiles in Heart Failure Patients: a systematic review and meta-analysis
Authors: Meybodi Seyed Mohammadmahdi , karimi Mohammad Amin , mousazadeh Kourosh , Pakmehr Seyed Abbas , Anar Mahsa Asadi , Alizadeh Alaleh , Poudineh Mohadeseh , Zerangian Nasibeh , Rahmanian Mohammad , Fathi Mobina , Yaghoobpoor Shirin , Rahimi Arash , Mojeni Fariba Arbab , Keylani Kimia , Banihashemian Seyedeh Zahra , Masoodi Mina , Aghazadeh-Habashi Komeil , Ghorbani Atousa , Faridzadeh Arezoo , Deravi Niloofar 
Published: January 2024

Abstract
Background and aim:
Sodium-glucose cotransporter two inhibitors could reduce cardiovascular events by modulating the lipid profile in patients with heart failure, irrespective of diabetes status. In this study, we aimed to assess the effect of SGLT-2 inhibitors on heart failure patients' lipid profiles via a meta-analysis.
Method
PubMed, Scopus, Web of Science, and Google Scholar databases were searched up to 2023 to retrieve relevant articles' titles, abstracts, and full text. STATA software was used to conduct the meta-analysis.
Result
Forest plot of fasting blood sugar levels in patients receiving SGLT2 differed significantly compared to control groups (mean difference =-0.08, 95%CI [-0.13, -0.02], p < 0.05). Analysis of lipid profile items, including total cholesterol, triglyceride, HDL, and LDL in HF patients receiving SGLT2, did not show a notable difference from the control group (p > 0.005). However, the mean difference was towards reduction for LDL, cholesterol, and triglycerides and showed an increase in HDL levels. Egger’s test for publication bias revealed some publication bias (p < 0.05).
Conclusion
Our topic analysis did not suggest notable lipid profile alterations. In order to come to a more firm agreement, more research on heart failure subjects is necessary because there is currently insufficient evidence.
Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments
Authors: Vendruscolo Michele , Milanesi Maria , Brotzakis Z. Faidon 
Published: January 2024

Abstract
A wide range of human disorders, including Alzheimer’s disease (AD), are characterised by the aberrant formation of amyloid fibrils. Amyloid fibrils are filamentous structures characterized by the presence of a highly-ordered cross-β core. In many cases, this core structure is flanked by disordered regions, often referred to as fuzzy coat. The structural properties of fuzzy coats, and the way in which they interact with their environments, however, have not been described in full detail to date. Here, we generated the conformational ensembles of two brain-derived amyloid filaments of Aβ42, corresponding respectively to familial and sporadic forms of AD. The approach that we used, called metadynamic electron microscopy metainference (MEMMI), enabled us to provide a characterization of the transient interactions between the fuzzy coat and the cross-β core of the filaments. These calculations indicated that the familial AD filaments are less soluble than the sporadic AD filaments, and that the fuzzy coat contributes to increasing the solubility of both types of filament. In addition, by analyzing the deviations between the density maps from cryo-EM and from the MEMMI structural ensembles, we observed a slowing down in the diffusion of water and sodium ions near the surface of the filaments, offering insight into the hydration dynamics of amyloid fibrils. These results illustrate how the metainference approach can help analyse cryo-EM maps for the characterisation of the properties of amyloid fibrils.
Association of PCSK6 polymorphisms with susceptibility risk of large artery atherosclerotic stroke
Authors: Chen Haiyan , Yun Yanfang , Yang Guixin , Yang Huadan , Jiang Yongming , Wei Baoying , Zhou Yingjie , Yuan Shengshan , Huang Jianjun , Wu Yingning , Huang Jianmin , Li Xuebin 
Published: January 2024

Abstract
Background
Recent studies have shown that PCSK6 is significantly associated with dyslipidemia, inflammatory reaction, cardiovascular diseases, atherosclerosis. However, the relationship between PCSK6 polymorphisms and large artery atherosclerosis stroke has not been reported. We performed this study to investigate whether the PCSK6 polymorphism is associated with risk of large artery atherosclerosis (LAA) stroke in the Chinese population.
Methods
Our study enrolled a total of 432 large artery atherosclerosis stroke cases and 448 healthy controls, cases and controls were genotyped at the polymorphic sites rs1135911 and rs20543. Multivariate logistic regression analyses were performed to analyze the associations between two snps and large artery atherosclerosis stroke susceptibility.
Results
Both rs1135911 and rs20543 were not associated with the distribution of responsible vessel stenosis in ischemic stroke. No significant effect was observed between the rs1135911 polymorphism and LAA stroke. Rs20543 was significantly correlated with LAA stroke (P<0.001), such difference remained statistically significant after adjusting for smoking history, hypertension, hypertriglyceridemia, high density lipoprotein cholesterol, and hyperhomocysteinemia, the difference remained significant (Recessive model: P = 0.000, OR = 0.526, 95%CI = 0.396–0.699 ).
Conclusion
Rs20543 AA genotype may be a protective factor for LAA stroke in Chinese population.
Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblasts
Authors: Wang Yuxin , Zhang Qian , Ding Liang , Li Jingyi , Liu Kunyu , Xia Chengwan , Chen Sheng , Huang Xiaofeng , Pu Yumei , Hu Qingang 
Published: January 2024

Abstract
Desmoplasia in fibroblasts within metastatic lymph nodes (MLNs) serves as an indicator of extranodal extension (ENE), which is a critical determinant of distant metastasis and mortality in oral squamous cell carcinoma (OSCC). However, systematic studies on fibroblasts in MLNs are lacking. Therefore, this study investigated and characterized the differences in phenotype, function, and origin of fibroblasts between primary tumors (PTs) and lymph nodes (LNs) in OSCC. We generated single-cell maps of PTs and paired MLNs and draining LNs from three OSCC patients. Among 44,052 fibroblasts, we identified two distinct subpopulations of cancer-associated myofibroblastic cells (mCAFs): RGS4+ mCAF1 and COMP+ mCAF2. Notably, mCAF1 and mCAF2 exhibited distinct distributions, with mCAF1 predominantly localized in the PT and mCAF2 in the MLN. Moreover, pseudotime analysis revealed their distinct origins: mCAF1 originated from inherent normal myofibroblastic cells in the PT, whereas mCAF2 originated from fibroblastic reticular cells in the LNs. Further differential analysis and in-vitro functional experiments using primary fibroblasts revealed that, compared to mCAF1, mCAF2 in MLN exhibited weaker crosstalk with immune cells but displayed enhanced extracellular matrix activity, which is closely linked to ENE formation in OSCC. Additionally, we identified two fibroblast subgroups in a transforming state, characterized by relatively low expression of fibroblastic marker genes but expressed specific epithelial canonical markers, indicating a potential epithelial–mesenchymal transition. Our research offers profound insights into the heterogeneity of fibroblasts between the PT and MLN in OSCC, serving as an essential resource for future drug discovery endeavors.
Legg Calve Perthes disease: a retrospective study of pelvic radiographic parameters
Authors: Varela-García María , Torrijos-Pulpón Carlos , Pino-López Laura , Farrag Yousof , Forneiro-Pérez Rocío , Conde-Aranda Javier , Gualillo Oreste , Pino Jesus 
Published: January 2024

Abstract

Purpose
Legg Calve Perthes disease (LCPD) is a paediatric hip disorder caused by ischemia of the femoral epiphysis, sometimes causing femoral head deformity. This study aims to determine if previously validated pelvic obliquity in skeletally immature patients through radiographic parameters for assessing acetabular retroversion in developmental dysplasia of the hip are applicable to patients with LCPD and its prognostic value.
Methods
A retrospective observational study of patients with Legg Calve Perthes disease was carried out, in which 4 pelvic parameters were studied: Ilioischial Angle, Obturator Index, Sharp’s Angle and Acetabular Depth-Width Ratio (ADR), analysing the differences between the healthy and affected hips. and subsequently, it is assessed whether the differences in these parameters may have a prognostic value in the outcome of the disease.
Results
Statistically significant differences have been obtained in the ilioischial angle, obturator index and ADR, between the affected and healthy hip. But regarding its value in the prognosis of the disease, only the Acetabular Depth Width Ratio has shown to have a predictive value of the outcome of the disease.
Conclusions
The present study showed that the pelvic parameters studied differ between the healthy and the diseased hip, but only one of them, the ADR, seems to have significance on the evolution and prognosis of the disease. More studies with a larger sample size are necessary, but we believe that studies on pelvic obliquity may open a new line of research in Legg Calve Perthes disease.
Investigating mining-induced disasters using earth observation time series data in the coal mines of Talcher region, Odisha
Authors: Behera Akash , Rawat Kishan Singh 
Published: January 2024

Abstract
The coal mining industry plays a pivotal role in powering the global energy demand, but it is not without environmental consequences. One of the significant environmental challenges associated with coal mining is mining-induced subsidence, which can result in ground deformation, land surface displacement, and infrastructure damage. This study focuses on investigating mining-induced subsidence in the Talcher region of Odisha, India, a prominent coal mining area, using earth observation time series data. The research leverages state-of-the-art satellite imagery and remote sensing techniques to monitor and analyze the subsidence patterns and trends in the Talcher coal mines. Over time, mining activities in the region have led to ground deformation and surface displacement, impacting the local environment and communities. This study utilizes a comprehensive time series of satellite data, including synthetic aperture radar (SAR) and optical imagery, to track subsidence and land surface changes. The objectives of this investigation include identifying areas susceptible to subsidence, quantifying the magnitude and rate of ground movement, and assessing the potential impact on local infrastructure and ecosystems. By utilizing earth observation data, it becomes possible to gain a deeper understanding of the dynamics of subsidence in the coal mining areas. The findings of this study are valuable not only for understanding the environmental repercussions of mining in the Talcher region but also for developing mitigation strategies and land-use planning to minimize the impact on local communities and the environment. This research contributes to the growing body of knowledge on mining-induced subsidence and provides insights into how earth observation data can be used to monitor and manage the consequences of coal mining in similar regions. Ultimately, the results of this study may inform policy decisions and sustainable mining practices to strike a balance between energy production and environmental conservation.
Metacommunity structure of benthic foraminifera in Rio de Janeiro coastal lagoons
Authors: Belart Pierre , Lorini Maria Lucia , Figueiredo Marcos Souza Lima , Bonetti Carla , Laut Lazaro 
Published: January 2024

Abstract

Metacommunity theory addresses local interactions and regional processes, offering a powerful framework to comprehend the species composition of a region and the factors that shape its structure along environmental gradients. By incorporating spatial dynamics, the metacommunity analysis explores the relationships that govern the ecological communities at different spatial scales. The objective of this work is to describe the structure of a metacommunity of living foraminifera, to relate it to physical and chemical variables of water and sediment, and to identify the environmental characteristics associated to the assemblages. A total of 534,416 living foraminifera, belonging to 65 species, were collected at 106 stations across five tropical urban coastal lagoons along the coast of the Rio de Janeiro State (Brazil), subjected to a strong salinity gradient. The results of the Elements of Metacommunity Structure (EMS) analysis identified four distinct assemblages of living foraminifera across the lagoonal systems. These metacommunities fitted a quasi-nested pattern, with the total variation explained by a shared influence of environmental factors (primarily hydrological drivers associated with marine influence, such as salinity, pH, and temperature) and spatial predictors. Organic enrichment descriptors (TOC, TS, CHO, PTN, LIP) played a secondary role in the ordination of the sites. The findings of this work demonstrate the potential of the EMS approach as a valuable tool for establishing a baseline in environmental monitoring plans.
Neural circuits underlying context-dependent competition between defensive actions in Drosophila larva
Authors: Jovanic Tihana , Lehman Maxime , Barré Chloé , Hasan Md Amit , Flament Benjamin , Autran Sandra , Dhiman Neena , Soba Peter , Masson Jean-Baptiste 
Published: January 2024

Abstract

To ensure their survival, animals must be able to respond adaptively to threats within their environment. However, the precise neural circuit mechanisms that underlie such flexible defensive behaviors remain poorly understood. Using neuronal manipulations, machine-learning-based behavioral detection, Electron Microscopy (EM) connectomics and calcium imaging in Drosophila larva, we have mapped the second-order interneurons differentially involved in the competition between different defensive actions and the main pathways to the motor side putatively involved in inhibiting startle-type behaviors and promoting escape behaviors in a context dependent manner. We found that mechanosensory stimulation modulates the nociceptive escape sequences and inhibits C-shape bends and Rolls in favor of startle-like behaviors. This suggests a competition between mechanosensory-induced startle responses and escape behaviors. Structural and functional connectivity revealed that the second order interneurons receive their main input from projection neurons that integrate mechanosensory and nociceptive stimuli. The analysis of their postsynaptic connectivity in EM revealed that they make indirect connections to the pre-motor and motor neurons. Finally, we identify a pair of descending neurons that could modulate the escape sequence and promote startle behaviors. Altogether, these results characterize the pathways involved in the startle and escape competition, modulated by the sensory context.
Contact Diode Laser for Posterior Laryngofissure in Pigs: Comparison Between 980nm and 1470nm Wavelengths
Authors: Rodrigues Isaac Faria Soares , Cardoso Paulo Francisco Guerreiro , Silva Natalia Aparecida Nepomuceno da , Correia Aristides Tadeu , Minamoto Helio , Bibas Benoit Jacques , Costa Natalia de Souza Xavier , Vasquez Marilia Wellichan Mancini , Dolhnikoff Marisa , Pego-Fernandes Paulo Manuel 
Published: January 2024

Abstract
Objective: To compare two different wavelengths of the surgical Contact Diode Laser (CDL) for producing a posterior laryngofissure in live pigs.
Methods: Anesthetized pigs underwent a tracheostomy and an anterior laryngofissure through a cervicotomy. They were randomly selected for the CDL wavelength and power (980nm wavelength: Ppeak power of 10W, 15W, and 20W, or 1470nm wavelength: Ppeak 3W, 5W, 7W, 10W). At the end of the experiment, the laryngotracheal specimen was extracted and sent for histology and morphometry measurements (incision size, depth, area, and lateral thermal damage). Hemodynamic data and arterial blood gases were recorded during the incisions. Statistical analysis of the comparisons between the parameters and groups had a level of significance of p <0.05.
Results: Twenty-six pigs were divided into CDL 980nm (n=11) and 1470nm (n=15). There was a larger incision area at the thyroid level in the 980nm CDL and a larger distance between borders in the tracheal level. There were no significant differences in the lateral thermal damage between the two groups and among the power levels tested.
Conclusion: Both wavelengths tested showed similar results in the various combinations of power levels without significant differences in the lateral thermal damage. The posterior laryngofissure incision can be performed safely by combining both wavelengths at low and medium power levels.
Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy
Authors: Kurokawa Koichiro , Yamada Yasutaka , Sakamoto Shinichi , Horikoshi Takuro , Sato Kodai , Namba Sakie , Kubota Yoshihiro , Kanesaka Manato , Fujimoto Ayumi , Takeuchi Nobuyoshi , Shibata Hiroki , Sazuka Tomokazu , Imamura Yusuke , Tsuzuki Toyonori , Uno Takashi , Ichikawa Tomohiko 
Published: January 2024

Abstract
The prognostic significance of unconventional histology (UH) subtypes including intraductal carcinoma of the prostate (IDC-P), ductal adenocarcinoma, and cribriform pattern has been investigated for prostate cancer (PCa). However, little is known about magnetic resonance imaging (MRI) features and the oncological impact of tumor localization in localized PCa with UH. Clinical data of 211 patients with acinar adenocarcinoma (conventional histology [CH]) and 82 patients with UH who underwent robotic-assisted radical prostatectomy (RARP) were reviewed. Patients with UH are more likely to be older and have higher Gleason grade group, higher Prostate Imaging-Reporting and Data System (PI-RADS) v2.1 score, and larger TV than those with CH. Multivariate analysis identified the presence of UH as an independent prognostic factor for biochemical recurrence (BCR) (hazard ration (HR) = 2.41, 95% confidence interval (CI): 0.22–0.79, P = 0.0073). No significant difference in BCR was seen regarding tumor localization (transition zone [TZ] or peripheral zone [PZ]) in patients with UH (P = 0.8949), whereas PZ cancer showed shorter BCR-free survival in patients with CH (P = 0.0174). PCa with UH was associated with higher BCR than PCa with CH among resection margin (RM)-negative cases (P < 0.0001). Further, increased PI-RADS v2.1 score did not correlate with larger TV in UH (P = 0.991), whereas a significant difference in TV was observed in CH (P < 0.0001). The prognostic significance of UH tumor was independent of tumor localization, and shorter BCR-free survival was observed even in RM-negative cases, indicating an aggressive subtype with micro-metastatic potential. Furthermore, UH tumors may decrease visibility on MRI. These findings will help optimal perioperative management for PCa with UH.
Narrative Mobile Video Game-based Cognitive Training to Enhance Frontal Function in Patients with Mild Cognitive Impairment
Authors: Choi Yeseul , Lim Jae-Sung , Choi Hagyun , Ryu Yong Hoe , Seong Eunkyung , Park Inseok , Kang Dong Won , Lee Jae-Hong , Kang Dong-Wha 
Published: January 2024

Abstract

Although cognitive training has been proposed as a possible therapeutic modality for mild cognitive impairment (MCI), most serious games focus on specific tasks. This study aimed to investigate the feasibility and efficacy of narrative video game-based cognitive intervention for MCI. A four-week (± 1-week) mobile game intervention was given to 17 MCI participants (mean age (SD) = 72.8(4.75)). At baseline and post-intervention, the participants received neuropsychological tests and a depression scale. Frontal function was assessed using the Corsi block-tapping test, Color Word Stroop Test, Controlled Oral Word Association Test, Digit Symbol Coding, and Trail Making Test-Elderly’s Version; depression was assessed using the GDS. User’s compliance and gaming experience were also evaluated. MCI patients showed significant improvements in frontal function, particularly in Digit Symbol Coding (mean (SD) = 0.47(0.49), p < .001), phonemic fluency (mean (SD) = 0.39(0.55), p < .01), and Trail Making Test Part B (mean (SD) = 0.85 (1.26), p = 0.01). Each frontal subtest’s mean z-score was increased (mean (SD) = 0.44(0.38), p < .001). Block span and depression scale remained unchanged. High adherence rates (122.35%) and favorable feedback on the gaming experience indicated that the game intervention’s usability boosted patients’ motivation and engagement. Our findings demonstrate that narrative game-based cognitive intervention was not only beneficial but also enjoyable for elderly MCI.
The Effect of Weight Self-Stigma on Social Appearance Anxiety in People With Obesity
Authors: kavak mustafa , erkan fatma melike , gültekin abdurrezzak , arslan mustafa , budak funda kavak 
Published: January 2024

Abstract

Background
Obese individuals are exposed to stigma and social appearance anxiety. Internalized weight stigma negatively affects mood, self-esteem, body image in obese individuals.
Aims
The aim of this study is to determine the effect of internalized weight stigma on social appearance anxiety in obese individuals.
Methods
The sample size of the study, which was conducted as a relational descriptor, consisted of 224 patients. "Descriptive Characteristics Form", "Internalized Weight Bias Scale" and "Social Appearance Anxiety Scale Adolescent Form" were used as data collection tools in the research.
Results
It was determined that there was a statistically strong positive correlation between internalized weight stigma and social appearance anxiety of obese individuals participating in the study (p < 0.05). In addition, it was determined that internalized weight stigma had statistical significance in explaining social appearance anxiety in obese individuals and predicted it at a rate of 67% (p < 0.05).
Conclusions
Considering the scale total score average in the study, it was found that the internalized weight stigma/bias and social appearance anxiety of obese individuals were high.
Decoding Predicted Musical Notes from Omitted Stimulus Potentials: Comparison of Familiar and Unfamiliar Melodies
Authors: Ishida Kai , Ishida Tomomi , Nittono Hiroshi 
Published: January 2024

Abstract
Electrophysiological studies have investigated predictive processing in music by examining event-related potentials (ERPs) elicited by the violation of musical expectations. While several studies have reported that the predictability of stimuli can modulate the amplitude of ERPs, it is unclear how specific the representation of the expected note is. The present study addressed this issue by recording the omitted stimulus potentials (OSPs) to avoid contamination of bottom-up sensory processing with top-down predictive processing. Decoding of the omitted content was attempted using a support vector machine, which is a type of machine learning. ERP responses to the omission of four target notes (E, F, A, and C) at the same position in familiar and unfamiliar melodies were recorded from 24 participants. The results showed that the omission N1 and the omission mismatch negativity were larger in the familiar melody condition than in the unfamiliar melody condition. The decoding accuracy of the four omitted notes was significantly higher in the familiar melody condition than in the unfamiliar melody condition. These results suggest that the OSPs contain discriminable predictive information, and the higher the predictability, the more the specific representation of the expected note is generated.