bluuebunny/crossref_metadata_2025_split huggingface dataset:
A metagenomic view of novel microbial and metabolic diversity found within the deep terrestrial biosphere at DeMMO: A microbial observatory in South Dakota, USA
Authors: Momper Lily , Casar Caitlin P. , Osburn Magdalena R. 
Published: November 2023

AbstractThe deep terrestrial subsurface is a large and diverse microbial habitat and vast repository of biomass. However, in relation to its size and physical heterogeneity we have limited understanding of taxonomic and metabolic diversity in this realm. Here we present a detailed metagenomic analysis of samples from the Deep Mine Microbial Observatory (DeMMO) spanning depths from the surface to 1.5 km into the crust. From eight geochemically and spatially distinct fluid samples we reconstructed ~600 partial to near‐complete metagenome‐assembled genomes (MAGs), representing 50 distinct phyla and including 18 candidate phyla. These novel clades include members of the candidate phyla radiation, two new MAGs from OLB16, a phylum originally identified in DeMMO fluids and for which only one other MAG is currently available, and new MAGs from the Eisenbacteria, Omnitrophota, and Edwardsbacteria. We find that microbes spanning this expansive phylogenetic diversity and physical subsurface space gain a competitive edge by maintaining a wide variety of functional pathways, are often capable of numerous dissimilatory energy metabolisms and poised to take advantage of nutrients as they become available in isolated fracture fluids. Our results support and expand on emerging themes of tight nutrient cycling and genomic plasticity in deep subsurface biosphere taxa.
Morphosyntactic Contact in Translation: Greek ídios and Latin proprius in the Bible
Authors: Benedetti Marina , Gianollo Chiara 
Published: November 2023

AbstractWe investigate the possibility that contact with Greek through the translation of biblical texts may have played a role in the development of Latin proprius ‘personal’, ‘peculiar’ into a reflexive possessive adjective. A few centuries earlier, post‐Classical Greek witnesses a similar development with the adjective ídios ‘private’, ‘personal’: we determine that in the New Testament this adjective has innovative uses as a reflexive possessive, and we argue that this is a system‐internal development triggered by the loss of the reflexive possessive forms of Classical Greek. The comparison between the Greek original and the Latin Vulgata translation of the New Testament furthermore shows that Latin proprius was used, with just one exception, as a translation equivalent of Greek ídios. We conclude that contact through translation acts as a catalyst for a change that, also in Latin, responds to the system‐internal pressure created by the loss of an unambiguous 3rd person reflexive possessive.
The Contribution of Germanic to the Expansion of Partitive‐Related Phenomena in the Prehistoric Circum‐Baltic Area1
Authors: Bucci Giacomo 
Published: November 2023

AbstractThe primary objective of this article is to expand the discussion on partitive‐related phenomena diffusion in the prehistoric Circum‐Baltic area by considering the role of early Germanic languages. The central message is that early Germanic languages have been historically overlooked in the study of partitive phenomena in the Circum‐Baltic area, and this paper aims to address this oversight. After briefly discussing the main hypotheses related to the development and spread of partitive functions, the focus will shift to two understudied phenomena in early Germanic languages, namely the ‘genitive of quantification’ and the ‘genitive of negation’. It will be shown that these two phenomena were present in early Germanic languages, suggesting that they should be included in further studies concerned with contact in the prehistoric Circum‐Baltic area.
‘Edited and Approved by Women for Maximum Benefit of all Readers’: Newsprint Journalism, the International Women's Year and the Remaking of a Gendered National Public in 1970s Ghana
Authors: Skinner Kate , Salifu Jovia , Ampofo Akosua Adomako 
Published: November 2023

AbstractDuring the International Women's Year (IWY) of 1975, United Nations bodies made concerted efforts to ensure global awareness and understanding of the IWY aims of equality, peace and development, via the mass media. In this article, we engage with these strategies of global information distribution from the vantage point of Ghana, West Africa. Drawing from interviews with women journalists and examples from the women's pages of the national state‐owned Daily Graphic newspaper, we argue that the onset of the IWY presented an important opportunity for women living under the constraints of military rule. A small but determined group of journalists capitalised on a longer history of readers writing into newspapers, and on lower levels of government surveillance of women's pages. Working with and through multi‐layered forms of address, they adapted the homey, gossipy women's pages and turned them into spaces of engagement between men and women as co‐citizens. During the IWY, connections were forged between international events and agendas and ‘domestic issues’. By hosting older debates about widowhood, inheritance and polygyny, and newer debates about family planning, formal education and employment, the women's pages positioned Ghanaian women as a key constituency in national development, but also enabled more assertive critiques of men's privileges.
Characterisation of meropenem‐resistant Bacillus sp. FW 1 isolated from biogas digestate
Authors: Sun He , Levenfors Jolanta J. , Brandt Christian , Schnürer Anna 
Published: November 2023

AbstractRecently a Bacillus sp. strain FW 1 was isolated from biogas digestate and shown to have novel resistance to meropenem (MEM), of critical importance in human medicine. MEM‐resistance has so far only been described for one species within the genus Bacillus, that is, Bacillus cereus. Bacillus is an abundant representative of the microbial community in biogas digesters and consequently, the finding indicates a risk of spreading such resistance when using the digestate as fertiliser. In this study, the Bacillus strain was characterised and classified as Heyndrickxia oleronia (previous Bacillus oleronius), previously not described to harbour MEM‐resistance. The mechanism of resistance was explored by metallo‐β‐lactamase (MBL) production, mapping of carbapenemase genes and genome analysis. The transferability of MEM‐resistance in strain FW 1 was investigated by plasmid transformation/conjugation, combined with genome analysis. The results confirmed MBL production for both strain FW 1 and the type strain H. oleronia DSM 9356T. However, elevated MEM resistance was found for strain FW 1, which was suggested to be caused by the production of unclassified carbapenemase, or overexpression of MBL. Moreover, the results suggest that the MEM‐resistance of strain FW 1 is not transferable, thus representing a limited risk of MEM‐resistance spread to the environment when using digestate on arable land.
Perioperative hypersensitivity in children: A prospective multidisciplinary study
Authors: Aydemir Sezin , Gemici Karaaslan Hatice Betul , Mustu Ulviye , Tin Oguzhan , Hakalmaz Ali Ekber , Ozcan Rahsan , Emre Senol , Kendigelen Pinar , Tutuncu Ayse Cigdem , Kiykim Ayca , Cokugras Haluk 
Published: November 2023

AbstractBackgroundThere are few studies of perioperative hypersensitivity reactions in children. The diagnosis of perioperative hypersensitivity reactions may be under estimated because it is difficult to recognize the reactions. Anaphylaxis may go unnoticed because of patient unconsciousness. Urticaria may be missed due to sterile drapes. The aim of this study was to prospectively evaluate perioperative hypersensitivity reactions.MethodsIn this prospective study, patients with suspected perioperative hypersensitivity reactions aged 0–18 years who underwent surgery at the Department of Pediatric Surgery, Cerrahpasa Faculty of Medicine, between 2019 and 2021 were investigated. Suspected reactions in the perioperative period were graded according to the Ring and Messmer scale. Patients with suspected reactions were examined 4–6 weeks after the reaction. If necessary, specific IgE and basophil activation tests were performed. Reactions of grades III–IV were considered anaphylaxis. If one test modality was strongly positive and there was a relevant time point or repeated allergic reactions, or at least two test modalities were positive, hypersensitivity was confirmed. In all patients, serum tryptase levels were analyzed at the time of the reaction, 2 h after the reaction, and 4–6 weeks after the reaction as part of the allergic evaluation.ResultsA total of 29 patients (8 female, 21 male) suspected of having an intraoperative reaction during the study were included in the analysis. Perioperative hypersensitivity reactions were noted in 1 patient. The incidence of perioperative hypersensitivity reactions was reported to be 0.03% (n = 1/2861). While anaphylaxis was confirmed in 1 patient, 5 patients were considered possible anaphylaxis cases.ConclusionPerioperative hypersensitivity reactions can be life‐threatening and may recur with further administration. Collaboration between pediatric surgeons, anesthesiologists, and allergists can prevent further reactions. All suspected cases should be evaluated by an experienced allergist soon after the initial reaction.
Management of primary plantar hyperhidrosis with botulinum toxin type A: A retrospective case series of 129 patients
Authors: Tsiogka Aikaterini , Agiasofitou Efthymia , Tsimpidakis Antonios , Kontochristopoulos George , Stratigos Alexander , Gregoriou Stamatios 
Published: November 2023

AbstractBackground/ObjectivesTo date, scientific data on the efficacy of botulinum toxin type A (BoNT‐A) for primary plantar hyperhidrosis (PPH) are mainly derived from case reports and small case series. Herein, we sought to assess the efficacy and safety of BoNT‐A for PPH on a large series of patients.MethodsMedical records of patients who were referred to the outpatient department for hyperhidrosis of a tertiary care hospital and received BoNT‐A for PPH from March 2003 until December 2022 were reviewed.ResultsA total of 129 patients [12 males, 117 females; median age 32 years (range, 16–72)] were included in the study, after excluding 24 patients with insufficient documented follow‐up data. Most patients [115 (89.1%)] received onabotulinumtoxin‐A, nine (7.0%) abobotulinumtoxin‐A and five (3.9%) both in subsequent sessions. The mean number of sessions was 2.02 [standard deviation (SD), 2.29] and the mean duration of response 6.16 months (SD, 4.01). The percentage of response, as evaluated by Minor's test, was 71.67%, 63.44%, 47.78% and 34.13% after 1, 3, 6 and 9 months, respectively. Most patients were satisfied (21.7%) or very satisfied (58.9%) with the treatment. No serious side effects were reported.ConclusionsThe results of this retrospective study suggest that BoNT‐A is an effective and safe treatment option for PPH.
The impact of body mass index on labour management and mode of delivery: A retrospective matched cohort study
Authors: Zheng Kan‐feng , Jones Madeleine N. , Mol Ben W. , Rolnik Daniel L. 
Published: November 2023

AimThis study aims to examine the association between body mass index (BMI) and mode of delivery, progression of labour, and intrapartum interventions.MethodsThis was a retrospective matched cohort study including Class III obese (BMI ≥40 kg/m2) and normal BMI (BMI <25 kg/m2) women planning a vaginal birth who had a live, singleton delivery from January 2015 to December 2018. Patients were matched (1:1) based on age, gestational age, parity, onset of labour and birth weight. The primary outcome was caesarean delivery (CD). Secondary outcomes were delivery outcomes, intrapartum management and interventions. Rates of each outcome were compared with matched analysis, and duration of labour with time‐to‐event analysis.ResultsWe studied two groups of 300 pregnant women. The CD rate was significantly higher for obese women than the normal BMI cohort (19.3% vs 13.3%; risk ratio (RR) 1.43, 95% CI 1.02–1.98, P = 0.035). Cervical dilation prior to CD for failure to progress was slower in obese than normal BMI (0.04 vs 0.16 cm/h). The obese cohort had a longer duration of labour in those who underwent induction (13.70 vs 11.48 h, P = 0.024). Intrapartum intervention rates were higher for obese women, with significant differences in rates of fetal scalp electrodes (72.7% vs 22.7%, RR 3.20, 95% CI 2.58–3.99, P < 0.001), intrauterine pressure catheters (18.3% vs 0%, P < 0.001), epidural analgesia (44.0% vs 37.0%, RR 1.20, 95% CI 1.01–1.44, P = 0.040) and fetal scalp lactate sampling (8.0% vs 3.0%, RR = 2.67, 95% CI 1.33–5.33, P = 0.004).ConclusionClass III obesity is associated with an increased risk of CD and intrapartum interventions.
What does it mean to be an allied health professional working in rural Aotearoa New Zealand? A qualitative study
Authors: Walker Sarah M. , Blattner Katharina , Nixon Garry , Koroheke Rogers Marara , Kennedy Ewan 
Published: November 2023

AbstractObjectiveBuilding health services and workforce that are both well supported and fit for purpose is a key consideration for improving health outcomes in rural populations. Achieving this requires an understanding of the roles and practice characteristic of each professional group, including allied health professionals. This study explores what it means to be an allied health professional practicing in rural Aotearoa New Zealand.DesignA qualitative study design was used, involving individual semi‐structured interviews with 13 rural allied health professionals in the Otago and Northland regions. The interviews explored participants journey into rural practice, their experiences working rurally, and their views on rural practice.FindingsFour main themes were derived: Identity; Connectedness; Expectations; and Providing Care.DiscussionProud of being rural, these allied health professionals are immersed within their community, intertwining their professional and personal identities. The unique nature of this dual identity while empowering for some, can also isolate rural allied health professionals from their professional bodies and urban peers. This leads to a sense of vulnerability and feeling undervalued and invisible. In response, rural allied health professionals choose to form strong connections to their local interprofessional team and their community. The connections they forge, and the breadth of their skills cumulate to enable allied health professionals to provide dynamic and responsive health services for their rural communities.ConclusionThis study provides the first insight into experiences and perspectives of allied health professionals within rural Aotearoa New Zealand. Despite the challenges, a sense of pride is associated with practicing rurally for allied health professionals.
Host defense amyloids: Biosensors of the immune system?
Authors: Myers Caitlyn , Cornwall Gail A. 
Published: November 2023

AbstractThere is considerable evidence showing that highly ordered aggregate structures known as amyloids carry out essential biological roles in species ranging from bacteria to humans. Indeed, many antimicrobial peptides/proteins form amyloids to carry out their host defense functions and many amyloids are antimicrobial. The similarity of host defense amyloids from bacterial biofilms to the mammalian epididymal amyloid matrix implies highly conserved host defense structures/functions. With an emphasis on the epididymal amyloid matrix, here we review the common properties of host defense amyloids including unique traits that would allow them to function as powerful biosensors of the immune system.
Minimising alarm pressure on a single room NICU through automated withdrawal of resolved alarms
Authors: Broer Shole D. L. , Cramer Sophie J. E. , Tan Ratna N. G. B. , Witlox Ruben S. G. M. 
Published: November 2023

AbstractAimIn 2017, the Leiden University Medical Centre implemented a secondary alarm system using handheld devices to ensure accurate patient monitoring on the single room NICU. Initially, alarms remained active on the handheld devices until one of the caregivers in the alarm chain accepted the alarm. In 2020, a bidirectional communication protocol (BCP) was implemented, enabling automated withdrawal of resolved alarms. The aim of this study was to evaluate the effect of this implementation on the alarm duration and pressure.MethodsData of all alarms of the secondary alarm chain in the 90 days before and after the implementation were analysed and compared between both periods.ResultsFollowing the implementation of the BCP, 60% of the alarms were withdrawn before the designated nurse responded. Despite a significant higher total number of alarms, the median alarm duration decreased from 9 (7–14) to 6 (4–10) s, the acceptance rate of the designated nurse increased from 93% to 95% and the median time of alarm sounding per phone per hour significantly decreased from 71 (51–101) to 51 (35–69) s following implementation of the BCP.ConclusionThis study showed that automated withdrawal of resolved alarms significantly reduces alarm duration and pressure on a NICU.
Gender pay gap in the microfinance industry: A global perspective
Authors: Mia Md Aslam , Dalla Pellegrina Lucia , Wong Wai‐Yan , Sangwan Sunil 
Published: November 2023

AbstractWe use a database composed of 2,545 Microfinance Institutions (MFIs) worldwide for the period 2008–18 to explore the effect of a larger share of women's workforce on both staff wages and overall monetary compensation within MFIs. MFIs are different from other industries, as they are traditionally women‐centered, i.e. they have a significant share of women employees at every level of the corporate hierarchy and mostly serve women clients. Applying both traditional estimation methodology and techniques aimed at accounting for possible endogeneity among the main variables, we find that a higher proportion of women on staff significantly increases the average expense per worker (which also includes the incentive components of remuneration) while the effects are considerably smoothed (or not significant) on the base salary. This leads us to conclude that, unlike what is seen in other sectors of the economy, MFIs do not pay women less. Yet, significant positive effects of women in the workforce, especially on average overall monetary compensation, suggest that women are likely to exploit their superior skills and/or gender affinity advantages with customers of the same gender to enhance MFIs’ efficiency and profitability, thereby achieving higher incentive compensation, mostly in the form of bonuses and other benefits.
Sequential cellular and humoral responses after repetitive COVID‐19 vaccination in patients treated with anti‐CD20 antibodies
Authors: Nishikubo Masashi , Shimomura Yoshimitsu , Yamamoto Ryusuke , Maruoka Hayato , Nasu Seiko , Sakizono Kenji , Nagai Yuya , Hiramoto Nobuhiro , Yonetani Noboru , Kondo Tadakazu , Miyakoshi Chisato , Doi Asako , Ishikawa Takayuki 
Published: November 2023

SummaryPatients treated with anti‐CD20 antibodies for haematological disorders have insufficient immune responses to mRNA COVID‐19 vaccines; however, relevant sequential data are lacking. We sequentially evaluated the humoral and cellular immune responses in 22 patients who had received anti‐CD20 antibodies within 12 months before the first vaccination, before and after the third and fourth vaccinations. Humoral responses improved gradually, along with the resolution of B‐cell depletion. A steady increase was noted in cellular responses, regardless of the B‐cell status. Our findings suggest the potential benefit of repeated vaccinations in these patients until B‐cell recovery is confirmed while enhancing cellular responses.
The use of mesenchymal stromal cell secretome to enhance guided bone regeneration in comparison with leukocyte and platelet‐rich fibrin
Authors: Shanbhag Siddharth , Al‐Sharabi Niyaz , Kampleitner Carina , Mohamed‐Ahmed Samih , Kristoffersen Einar K. , Tangl Stefan , Mustafa Kamal , Gruber Reinhard , Sanz Mariano 
Published: November 2023

AbstractObjectivesSecretomes of mesenchymal stromal cells (MSC) represent a novel strategy for growth‐factor delivery for tissue regeneration. The objective of this study was to compare the efficacy of adjunctive use of conditioned media of bone‐marrow MSC (MSC‐CM) with collagen barrier membranes vs. adjunctive use of conditioned media of leukocyte‐ and platelet‐rich fibrin (PRF‐CM), a current growth‐factor therapy, for guided bone regeneration (GBR).MethodsMSC‐CM and PRF‐CM prepared from healthy human donors were subjected to proteomic analysis using mass spectrometry and multiplex immunoassay. Collagen membranes functionalized with MSC‐CM or PRF‐CM were applied on critical‐size rat calvaria defects and new bone formation was assessed via three‐dimensional (3D) micro‐CT analysis of total defect volume (2 and 4 weeks) and 2D histomorphometric analysis of central defect regions (4 weeks).ResultsWhile both MSC‐CM and PRF‐CM revealed several bone‐related proteins, differentially expressed proteins, especially extracellular matrix components, were increased in MSC‐CM. In rat calvaria defects, micro‐CT revealed greater total bone coverage in the MSC‐CM group after 2 and 4 weeks. Histologically, both groups showed a combination of regular new bone and ‘hybrid’ new bone, which was formed within the membrane compartment and characterized by incorporation of mineralized collagen fibers. Histomorphometry in central defect sections revealed greater hybrid bone area in the MSC‐CM group, while the total new bone area was similar between groups.ConclusionBased on the in vitro and in vivo investigations herein, functionalization of membranes with MSC‐CM represents a promising strategy to enhance GBR.
The Meaning of Motion Lines?: A Review of Theoretical and Empirical Research on Static Depiction of Motion
Authors: Hacımusaoğlu Irmak , Cohn Neil 
Published: November 2023

AbstractStatic depiction of motion, particularly lines trailing behind a mover, has long been of interest in the psychology literature. Empirical research has demonstrated that these “motion lines” benefited motion comprehension in static images by disambiguating the direction of movement. Yet, there is no consensus on how those lines derive their meaning. In this article, we review three accounts suggesting different interpretations of what motion lines represent. While a perceptual account considers motion lines originating from motion streaks in the primary visual cortex, metaphorical and lexical accounts propose them as graphical conventions that should be learned—either through resemblance to sensory experiences (e.g., natural path marks) or directly being mapped to a conceptual category of paths. To contrast these three accounts, we integrate empirical research on motion lines and their understanding. Overall, developmental, proficiency, and cross‐cultural variances indicate that the understanding of motion lines is neither innate nor universal, thus providing less support for lines having a purely perceptual origin. Rather, we argue the empirical findings suggest that motion lines are not iconic depictions of visual percepts but are graphical conventions indexing conceptual path information, which need to be learned and encoded in a visual lexicon.