bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential gradients of immunotherapy vs targeted therapy efficacy according to the sun-exposure pattern of the site of occurrence of primary melanoma: a multicenter prospective cohort study (MelBase)
Authors: Russo David , Dalle Stéphane , Dereure Olivier , Mortier Laurent , Dalac-Rat Sophie , Dutriaux Caroline , Leccia Marie-Thérèse , Legoupil Delphine , Montaudié Henri , Maubec Eve , De Quatrebarbes Julie , Arnault Jean-Philippe , Brocard Florence Granel , Saïag Philippe , Dreno Brigitte , Allayous Clara , Oriano Bastien , Lefevre Wendy , Lebbé Céleste , Boussemart Lise 
Published: October 2023

BackgroundThe tumor mutational burden (TMB) is high in melanomas owing to UV-induced oncogenesis. While a high TMB is a predictive biomarker of response to PD-1 inhibitors, it may be associated with the rise of resistant clones to targeted therapy over time. We hypothesized that survivals may depend on both the sun-exposure profile of the site of primary melanoma and the type of systemic treatment.Patients and methodsPatients were screened from MelBase, a multicenter biobank dedicated to the prospective follow-up of stage III/IV melanoma. All patients with a known cutaneous primary melanoma who received a 1st-line systemic treatment by immunotherapy or targeted therapy were included (2013-2019). Outcomes were progression-free survival (PFS) and overall survival (OS).Results973 patients received either anti PD-1(n=466), anti CTLA-4(n=143), a combination of both (n=118), or targeted therapies (n=246). Patients’ characteristics at treatment initiation were: male (62%), median age of 62, AJCC stage IV (84%). Median follow-up was 15.5 months. The primary melanoma was located on chronically sun-exposed skin in 202 patients (G1: head neck), on intermittently sun-exposed skin in 699 patients (G2: trunk, arms, legs), and on sun-protected areas in 72 patients (G3: palms, soles). Median PFS was significantly higher in G1 under anti PD-1 treatment (8.7 months vs 3.3 and 3.4 months for G2 and G3, respectively) (p=0.011). PFS did not significantly differ in other groups. Similarly, median OS was significantly higher in G1 receiving 1st line anti PD-1 treatment (45.6 months vs 31.6 and 21.4 months for G2 and G3) (p=0.04), as opposed to 1st line targeted therapy (19.5 months vs 16.3 and 21.1 months for G1, G2 and G3 respectively).ConclusionOur study confirms that immunotherapy with anti PD-1 is particularly recommended for melanomas originating from chronically sun-exposed areas, but this finding needs to be confirmed by further research.
Accurate and non-invasive localization of multi-focal ground-glass opacities via electromagnetic navigation bronchoscopy assisting video-assisted thoracoscopic surgery: a single-center study
Authors: Zeng Chenxi , Yang Guang , Wei Lu , Wang Junhui , Wang Xue , Ye Fan , Fu Xiangning , Cai Yixin , Wang Jianing 
Published: October 2023

BackgroundAccurate localization of multi-focal ground-glass opacities (GGOs) is crucial for successful video-assisted thoracoscopic surgery (VATS). Electromagnetic navigation bronchoscopy (ENB) provides a minimally invasive and dependable approach for precise localization. This study assessed the accuracy and safety of ENB-guided localization in cases involving multi-focal GGOs.MethodsThis retrospective study presents a single-center investigation into ENB-guided localization, utilizing methylene blue, for multi-focal GGOs assisting VATS. Clinical, surgical, and pathological data were collected from patients who underwent ENB-guided localization between 23 December 2019 and 31 August 2022.ResultsThe study examined 57 patients with multi-focal GGOs who underwent ENB-guided localization and VATS. A total of 150 GGOs were treated, with ENB-guided localization taking a median time of 65 min. Following localization, all patients proceeded to VATS, with a median duration of 170 min. The median lesion size measured 7.8 mm, with a 5-mm distance between GGO and pleura or fissure. When the distance between GGO and pleura/fissure exceeded 1 cm, an additional location point was introduced below the pleura or fissure based on GGO location. No complications related to localization were observed. The overall malignancy rate stood at 66%. Location precision was confirmed by measuring the marker-to-GGO lesion distance, resulting in a 94% (141/150) accuracy rate for GGO localization.ConclusionENB-guided methylene blue injection is a safe and precise method to treat multi-focal GGOs, potentially minimizing operation time and simplifying lesion detection.
Establishment of a condition-specific quality-of-life questionnaire for children born with esophageal atresia aged 2–7 across 14 countries
Authors:   The International EA-QOL Group
Published: October 2023

BackgroundEsophageal atresia (EA) is a rare congenital anomaly characterized by a discontinuity of the esophagus. Following surgical repair, survival rates have improved dramatically the past decenniums and today exceed 90%, but the children commonly present with esophageal and respiratory morbidity. In 2018, a condition-specific quality-of-life questionnaire for children with esophageal atresia (EA) aged 2–7 in Sweden-Germany was finalized (The EA-QOL questionnaire). The study aim was to describe the evaluation of the new translations across 12 new countries in Europe, Asia, Africa, Central-and North America.MethodsFollowing forward-backward translation into the new languages, the 17-item EA-QOL questionnaire was tested in cognitive debriefing interviews with parents of children with EA aged 2–7. Parents rated if each item was easy to understand (clarity) and sensitive to answer (interference with personal integrity). They could skip responding to a non-applicable/problematic item and give open comments. Predefined psychometric criteria were used; item clarity ≥80%/item sensitive to answer ≤20%/item feasibility ≤5% missing item responses. The decision to modify the translation was based on native expert, patient stakeholder, and instrument developer review, and the need for harmonization between translations.ResultsSimilar to findings in the Swedish-German cognitive debriefing, the cross-cultural analysis of input from 116 parents from 12 new countries (4–14 parents, median 9 parents/country) showed that all items in the EA-QOL questionnaire fulfilled the criteria for item clarity ≥80% and sensitive to answer (ranging from 1%-4.5%), although results varied between countries. Four items had missing responses between 5.2% and 13.4%, three within the same domain and were in line with parents’ explanations. Poor translations and feasibility were improved.ConclusionsBased on parent input, the collaboration between native experts, patient stakeholders, and instrument developers, a linguistic version of the EA-QOL questionnaire for children aged 2–7 for use in and across 14 countries has been established. These efforts have set the conditions for a cross-cultural field test of the EA-QOL questionnaire and will open the doors for a new chapter in outcome research, registries, and clinical practice concerning children with EA. In the long-term, this will help increase knowledge of the disease's burden, promote patient-centeredness, exchange of information between nations, and strengthen evidence-based treatments for children born with EA.
Genome-wide association analysis of Monilinia fructicola lesion in a collection of Spanish peach landraces
Authors: Martínez-García Pedro J. , Mas-Gómez Jorge , Prudencio Ángela S. , Barriuso Juan José , Cantín Celia M. 
Published: October 2023

Brown rot, caused by the Monilinia spp., is the disease that causes the greatest losses in stone fruit worldwide. Currently, M. fructicola has become the dominant species in the main peach production area in Spain. The fruit cuticle is the first barrier of protection against external aggressions and may have a key role in the susceptibility to brown rot. However, information on the role of skin fruit on the resistance to brown rot in peach is scarce. Previous genetic analyses in peach have demonstrated that brown rot resistance is a complex and quantitative trait in which different fruit parts and resistance mechanisms are involved. To search for genomic areas involved in the control of the cultivar susceptibility to brown rot and to elucidate the role of fruit skin against this infection, we have studied, for two consecutive seasons (2019 and 2020), the fruit susceptibility to M. fructicola, together with fruit cuticle thickness (CT) and density (CD), in a collection of 80 Spanish and 5 foreign peach cultivars from the National Peach Collection at CITA (Zaragoza, Spain). Brown rot incidence, lesion diameter, and severity index were calculated after 5 days of inoculation on non-wounded fruit. The peach collection has also been genotyped using the new peach SNP chip (9 + 9K). Genotypic and phenotypic data have been used to perform a genome-wide association analysis (GWAS). Phenotyping has shown a wide variability on the brown rot susceptibility within the Spanish germplasm as well as on CD and CT. The GWAS results have identified several significant SNPs associated with disease severity index (DSI), CD, and CT, five of which were considered as reliable SNP-trait associations. A wide protein network analysis, using 127 genes within the regions of the reliable SNPs and previously identified candidate genes (169) associated with Monilinia spp. resistance, highlighted several genes involved in classical hypersensitive response (HR), genes related to wax layers as ceramidases and lignin precursors catalyzers, and a possible role of autophagy during brown rot infection. This work adds relevant information on the complexity resistance mechanisms to brown rot infection in peach fruits and the genetics behind them.
Verbal memory and executive components of recall in adolescent binge drinkers
Authors: Porras Truque Claudia , García Moreno Luis Miguel , Gordo Patricia Mateos , Ordoñez Xavier G. , Cadaveira Fernando , Corral Montserrat 
Published: October 2023

IntroductionBinge drinking (BD) is a common health-risk behavior among young people. Due to the incomplete maturation of the adolescent brain, BD can lead to structural and functional changes that impact neurocognitive processes, particularly executive functioning and verbal memory. This study aimed to investigate the influence of executive components, such as mnemonic strategies and error avoidance, on performance in a verbal memory test and the potential effects of BD on this performance.MethodsA sample of 160 college students (51.55% female) with a mean age of 18.12 ± 0.32 years completed assessments for alcohol use disorders using the Alcohol Use Disorder Identification Test (AUDIT), as well as psychopathological (Symptom Checklist-90-R) and neuropsychological evaluations (Verbal Learning Test Spain-Complutense and WMS-III Logical Memory). The Intensive Drinking Evaluation Instrument (IECI) was utilized to gather detailed information about binge drinking habits, including the calculation of the highest blood alcohol concentration (BAC) during an episode of intake.ResultsCorrelation and clustering analyses revealed a negative association between BAC values and verbal memory performance, as well as the use of memory strategies. The high BAC group (BD) exhibited negative values in verbal memory variables, higher accuracy errors, and less efficient strategy usage, while the low BAC group (No BD) demonstrated better memory test performance, fewer precision errors, and superior use of memory strategies.DiscussionThese findings support the hypothesis that, when solving tests requiring verbal memory, adolescents reporting a BD consumption pattern show fewer executive skills in their resolution and, therefore, achieved poorer performance than non-binge drinkers. Addressing excessive alcohol consumption in young individuals is crucial for safeguarding their cognitive development and overall well-being.
Influence of job demands on implicit absenteeism in Chinese nurses: mediating effects of work–family conflict and job embeddedness
Authors: Zhang Yujie , Lei Shanyan , Chen Liying , Yang Fang 
Published: October 2023

PurposeIt has been widely noted that implicit absenteeism is common among nurses, with job demand influencing it. Theoretically, work–family conflict and job embeddedness may help link job demands to implicit absenteeism. However, the mediating effects of the two on the association between job demands and implicit absenteeism remain unclear. Thus, this study aims to explore the association between nurses’ job demands and implicit absenteeism, and the chain mediating effect of work–family conflict and job embeddedness in this relationship.Patients and methodsData were collected from 1,420 nurses from five tertiary public hospitals in China. They were asked to respond to a questionnaire asking about job demands, implicit absenteeism, work–family conflict, and job embeddedness. The data were coded and analyzed using IBM SPSS version 21.0. Descriptive analysis, t-test, one-way ANOVA, hierarchical multiple regression analysis, and bootstrapping were used to analyze the extracted data.ResultsThe mean score for implicit absenteeism was 17.75 ± 5.60. There was a significant correlation (p &lt; 0.05) between nurses’ job demands, work–family conflict, job embeddedness, and implicit absenteeism. Nurses’ job demands directly influenced implicit absenteeism and indirectly influenced implicit absenteeism through the mediating effects of work–family conflict and job embeddedness. Furthermore, work–family conflict and job embeddedness have a chain effect on the association between job demands and implicit absenteeism.ConclusionThe study found that nurses’ job demands directly and positively influence implicit absenteeism, and indirectly influence implicit absenteeism through single and chain mediating effects of work–family conflict and job embeddedness.
Psychological changes among women with recurrent pregnancy loss during the COVID-19 period in northeastern China: a cross-sectional study
Authors: Wang Tingting , Hou Yue , Liu Yilin , Qiao Chong 
Published: October 2023

BackgroundIt aimed to investigate the prevalence of anxiety and depression in recurrent pregnancy loss (RPL) women and the related factors in Northeastern China during the Coronavirus disease 2019 (COVID-19) pandemic.MethodsFrom March to June 2021, we conducted an electronic questionnaire survey of 267 RPL women who attended the recurrent pregnancy loss clinic at Shengjing Hospital of China Medical University. The State–Trait Anxiety Inventory (STAI), Beck Depression Inventory-II (BDI-II), Perceived Stress Scale (PSS), and Medical Outcomes Study Social Support Survey (MOS-SSS-C) were used to screen for anxiety, depression, stress, and social support. Logistic regression was used to explore the related factors of anxiety and depression.ResultsRPL women had severe psychological problems during the pandemic: 56.6% showed state anxiety or trait anxiety, 26.6% showed high levels of stress, and 13.1% showed depression. Economic pressure caused by COVID-19, and high stress were common related factors for anxiety and depression. The interval since last miscarriage &lt;6 months, worse mood changes due to COVID-19, and concerns about COVID-19 were associated with anxiety. A history of pregnancy loss &gt;14 weeks was associated with depression. While adequate social support and actively seeking health help were protective factors for trait anxiety. And identifying the etiology was a protective factor for depression.ConclusionThe study revealed the prevalence of anxiety, depression, and the associated factors in RPL women during COVID-19. More attention should be paid to the psychology of RPL women and adequate social support should be provided.
Exploring the relationship between vitamin D deficiency and comorbid heart disease in Americans with mood disorders: a cross-sectional nationwide study
Authors: Habib Maleeha , Jaka Sanobar , Pokhrel Sandesh , Sejdiu Albulena , Patel Archna , Vashist Sreshatha , Arisoyin Abimbola , Pathak Meenal , Bachu Anil K. , Rajaram Manoharan Senthil Vel Rajan , Mogallapu Raja , Patel Rikinkumar S. 
Published: October 2023

ObjectiveThis study aimed to explore the relationship between vitamin D deficiency and comorbid heart disease in adult inpatients with mood disorders (depressive and bipolar disorders).MethodsA cross-sectional investigation was carried out employing the nationwide inpatient dataset, which encompassed 910,561 adult inpatients aged 18 to 50 years diagnosed with depressive and bipolar disorders. Additionally, the sample was categorized based on the presence of comorbid heart disease. We utilized a logistic regression model to assess the odds ratio (OR), pertaining to demographic features and coexisting medical conditions in relation to comorbid heart disease.ResultsComorbid heart disease was present in 1.3% of inpatients with mood disorders; they were middle-aged (mean age 42.7 years) men and White individuals. Inpatients with depressive disorder had a higher risk of comorbid heart disease (OR 1.19, 95% CI 1.15–1.24) compared to those with bipolar disorders. Inpatients with comorbid heart disease had a higher prevalence of medical and psychiatric comorbidities. The prevalence of vitamin D deficiency was 2.3% in mood disorders but higher in those with comorbid heart disease (2.9%). Vitamin D deficiency showed a notable correlation with comorbid heart disease, resulting in a 26% increased risk in the unadjusted regression model (OR 1.26, 95% CI 1.13–1.40). However, after accounting for potential confounding factors, including comorbidities, the risk did not exhibit statistical significance (OR 1.08, 95% CI 0.97–1.21). Among psychiatric comorbidities, trauma-related (OR 1.22, 95% CI 1.17–1.28) and tobacco-related (OR 1.31, 95% CI 1.26–1.37) disorders had a higher risk of association with comorbid heart disease.ConclusionMiddle-aged men with depressive disorders and from low-income families had a higher risk of developing comorbid heart disease. Trauma-related and tobacco-related disorders were associated with an increased risk by 20–30% for comorbid heart disease in inpatients with mood disorders. Vitamin D deficiency was not associated with the risk of comorbid heart disease after controlling demographics and comorbid cardiovascular risk factors.
Community treatment of latent tuberculosis in child and adult refugee populations: outcomes and successes
Authors: Harwood-Johnson Emily , Leis Karen S. , Hanson Jacelyn , Olfert Jordan , Blonde Yvonne , Brindamour Mahli 
Published: October 2023

BackgroundTuberculosis (TB) is the world’s leading infectious cause of death, killing millions every year. In Canada, considered a low-incidence country for TB, the burden of the disease is unequally distributed, with most cases of latent tuberculosis infection (LTBI) experienced by newcomers from endemic regions. The purpose of this study was to measure LTBI treatment acceptance and completion outcomes of LTBI treatment at the REACH clinic in Saskatoon, a local refugee clinic providing primary care-based LTBI management.MethodsA retrospective case series by sampling methodology was applied to review patients who visited the REACH clinic between January 2017 and June 2021 and who had an interferon-gamma release assay (IGRA) or tuberculin skin test (TST) done for LTBI screening. Those with positive results were retained for analysis. The LTBI treatment acceptance and completion groups were compared according to demographic variables, WHO regions of origin, year of arrival to Canada, and LTBI treatment regimen.ResultsA total of 523 patients were screened for LTBI, of whom 125 tested positive, leading to a test positivity of 23.9%. The treatment acceptance rate was 84.8%, and the treatment completion rate was 93.3%. All of those who declined treatment were more than 18 years of age (p = 0.02). Otherwise, treatment acceptance and completion rates did not vary significantly in association with gender, categories of refugees, WHO region of origin, year of arrival to Canada, or LTBI treatment regimen used.DiscussionThe refugee clinic acceptance and completion rates in this study are high and meet Canadian TB standards of care. The multidisciplinary clinic model and community support are important facilitators, which, in combination with shorter treatment regimens, offer a path forward for LTBI management among refugees resettling in low-incidence countries.
HUBUNGAN KONSUMSI PROTEIN DAN ZINK SERTA RIWAYAT PENYAKIT INFEKSI DENGAN STUNTING PADA ANAK USIA 0-5 TAHUN DI UPTD PUSKESMAS LAMEPAYUNG KABUPATEN KUNINGAN TAHUN 2023
Authors: Saprudin Nanang , Igustia Tia , Nengsih Neneng Aria 
Published: October 2023

Stunting disebabkan oleh asupan gizi yang kurang, dan riwayat penyakit infeksi yang berpengaruh langsung terhadap 1000 hari pertama kehidupan (HPK) yang merupakan masa kritis. Hasil studi pendahuluan didapatkan responden yang mengalami stunting disebabkan karena anak kurang mengonsumsi asupan protein dan zink, serta kurangnya menjaga kebersihan rumah yang menyebabkan anak mudah terserang penyakit infeksi. Penelitan ini bertujuan untuk menganalisis faktor yang berhubungan dengan stunting pada anak usia 0-5 tahun. Jenis penelitian analitik retrosfektif dengan desain penelitian crossectional. Populasi seluruh anak stunting di UPTD Puskesmas Lamepayung. Jumlah sampel sebanyak 44 responden dengan teknik total sampling. Instrumen penelitian menggunakan lembar observasi, microtoise untuk mengukur tinggi badan, catatan rekam medis, dan kuesioner yang sudah diuji validitas. Analisis data univariat menggunakan distribusi frekuensi serta analisis data bivariat menggunakan uji chi-square. Sebagian besar responden (52,3%) memiliki konsumsi protein yang baik, sebagian besar (56,8%) memiliki konsumsi zink kurang, sebagian besar (61,4%) stunting dengan kategori sangat pendek dan hampir seluruh responden (93,2%) memiliki riwayat penyakit infeksi dalam tiga bulan terakhir. Hasil analisis bivariat : konsumsi protein (p value = 0,025), konsumsi zink (p value = 0,009), riwayat penyakit infeksi (p value = 0,018). Terdapat hubungan antara konsumsi protein dan zink serta riwayat penyakit infeksi dengan stunting pada anak usia 0-5 tahun di UPTD Puskesmas Lamepayung Kabupaten Kuningan Tahun 2023. Disarankan kepada para orang tua untuk memberikan asupan protein dan zink seperti, daging, aneka seafood, kacang-kacangan, sayuran dan buah-buahan untuk mengurangi risiko terjadinya stunting. Selain itu, kebersihan lingkungan sangat penting untuk kesehatan anak dan keluarga agar tidak mengalami penyakit infeksi secara berulang.
MENCEGAH DEGRADASI EKONOMI DAN MENINGKATKAN OBJEK WISATA DESA MENTIGI
Authors: Aji Setiawan  , Alfiyyah Berliani  , Yodi  , Erick Prayogo Walton  
Published: October 2023

Masalah mitra di desa mentigi yaitu (1) UMKM sudah bagus, tetapi cara promosinya kurang inovatif. Kemudian dari segi wisata, pengelolaan wisatanya terbengkalai dan promosi wisatanya masih kurang. [1]Strategi pemasaran menurut (Kotler and Amstrong, 2012:72) adalah logika pemasaran dimana perusahaan berharap dapat menciptakan nilai bagi customer dan dapat mencapai hubungan yang menguntungkan dengan pelanggan. (2) Tujuan : Untuk menyediakan platform interaktif dan edukatif untuk memahami pentingnya pelestarian lingkungan dan meningkatkan kesadaran dan pemahaman wisatawan tentang pentingnya konservasi lingkungan, keanekaragaman hayati, dan ekosistem melalui penggunaan teknologi informasi yang interaktif dan edukatif.[2] konservasi menurut UU No 5 Tahun 1990 Konservasi sumber daya alam hayati adalah pengelolaan sumber daya alam hayati yang pemanfaatannya dilakukan secara bijaksana untuk menjamin kesinambungan persediaannya dengan tetap memelihara dan meningkatkan kualitas keanekaragaman dan nilainya. (3) Metode : Penyuluhan tentang pengembangan UMKM,mempromosikan tempat wisata melalui media sosial secara aktif. Metode kedua yaitu, cara mengelola wisata tersebut agar tidak terbengkalai berkerjasama dengan Mitra yang terlibat bumdes sedangkan dari UMKM dari Ibu PKK dan warga desa mentigi. (4) Dari hasil yang dicapai mahasiswa dapat memberikan dampak yang positif untuk pencegahan degradasi ekonomi didesa mentigi dengan memberdayakan kekayaan alam yang ada.