bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nursing home managers’ quality of work life and health outcomes: a pre-pandemic profile over time
Authors: Penconek Tatiana , Duan Yinfei , Iaconi Alba , Tate Kaitlyn , Cummings Greta G , Estabrooks Carole A 
Published: February 2024

AimTo examine trends in quality of work life and health outcomes of managers in nursing homes in Western Canada pre-pandemic.MethodsA repeated cross-sectional descriptive study using data collected in 2014–2015, 2017 and 2019–2020, in the Translating Research in Elder Care Programme. Self-reported measures of demographics, physical/mental health and quality of work life (eg, job satisfaction, burnout, work engagement) were administered and completed by nursing home managers. We used two-way analysis of variance to compare scores across times, controlling for clustering effects at the nursing home level.ResultsSamples for data collection times 1, 2, 3, respectively, were 168, 193 and 199. Most nursing home managers were nurses by profession (80.63–81.82%). Job satisfaction scores were high across time (mean=4.42–4.48). The physical (mean=51.53–52.27) and mental (mean=51.66–52.13) status scores were stable over time. Workplace engagement (vigour, dedication and absorption) scores were high and stable over time in all three dimensions.ConclusionsNursing home managers were highly satisfied, had high levels of physical and mental health, and generally reported that their work was meaningful over time pre-COVID-19 pandemic. We provided a comparison for future research assessing the impacts of the pandemic on quality of work life and health outcomes.
The importance of core for carbonate reservoir evaluation: a case study from the Barra Velha Formation, Santos Basin, Brazil
Authors: Wood Hannah , Barnett Andrew , Follows Edward , Ribeiro Priscila , Guha Jaydip , Wheeler Josephine , Avila Runer 
Published: February 2024

Abstract

The lacustrine carbonates of the Barra Velha Formation are a prolific hydrocarbon reservoir in the Santos Basin, Brazil. In many fields, they comprise decimetre- to metre-scale cycles composed of laminated calcimudstones, spherulite and shrub-dominated facies. However, locally these cycles are replaced by decametre packages of re-worked shrub grainstone/rudstone/breccia and
in situ
shrub framestone with significant (>30°) depositional dips. The latter could be interpreted in several ways (e.g. fault-block highs, carbonate mounds), but the integration of seismic, borehole image log and whole-core datasets converge on a model of aggrading carbonate mounds which developed in or marginal to a lake setting. The core datasets in this study demonstrate a distinctive depositional fabric within the carbonate mounds.

From a production geology standpoint, the crucial difference between mound- and cyclothem-dominated successions is their permeability architecture. Cyclothem-dominated intervals show prominent and laterally continuous, decimetre-scale vertical matrix permeability variations. Mound-dominated intervals lack fine-scale palaeo-horizontal layering and exhibit a greater prevalence of irregular, centimetre-scale conduits and higher vertical permeability. This difference can only be reliably characterized via the integration of whole-core samples with other datasets and has a significant quantified impact on sweep and production performance.
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
Authors: Yamamoto Takehiro , Hayashida Tetsu , Masugi Yohei , Oshikawa Kiyotaka , Hayakawa Noriyo , Itoh Mai , Nishime Chiyoko , Suzuki Masami , Nagayama Aiko , Kawai Yuko , Hishiki Takako , Matsuura Tomomi , Naito Yoshiko , Kubo Akiko , Yamamoto Arisa , Yoshioka Yujiro , Kurahori Tomokazu , Nagasaka Misa , Takizawa Minako , Takano Naoharu , Kawakami Koji , Sakamoto Michiie , Wakui Masatoshi , Yamamoto Takushi , Kitagawa Yuko , Kabe Yasuaki , Horisawa Kenichi , Suzuki Atsushi , Matsumoto Masaki , Suematsu Makoto 
Published: February 2024

Abstract

Triple-negative breast cancer (TNBC) chemoresistance hampers the ability to effectively treat patients. Identification of mechanisms driving chemoresistance can lead to strategies to improve treatment. Here, we revealed that protein arginine methyltransferase-1 (PRMT1) simultaneously methylates D-3-phosphoglycerate dehydrogenase (PHGDH), a critical enzyme in serine synthesis, and the glycolytic enzymes PFKFB3 and PKM2 in TNBC cells. 13C metabolic flux analyses showed that PRMT1-dependent methylation of these three enzymes diverts glucose toward intermediates in the serine-synthesizing and serine/glycine cleavage pathways, thereby accelerating the production of methyl donors in TNBC cells. Mechanistically, PRMT1-dependent methylation of PHGDH at R54 or R20 activated its enzymatic activity by stabilizing 3-phosphoglycerate binding and suppressing polyubiquitination. PRMT1-mediated PHGDH methylation drove chemoresistance independently of glutathione synthesis. Rather, activation of the serine synthesis pathway supplied α-ketoglutarate and citrate to increase palmitate levels through activation of fatty acid synthase (FASN). Increased palmitate induced protein S-palmitoylation of PHGDH and FASN to further enhance fatty acid synthesis in a PRMT1-dependent manner. Loss of PRMT1 or pharmacologic inhibition of FASN or protein S-palmitoyltransferase reversed chemoresistance in TNBC. Furthermore, IHC coupled with imaging MS in clinical TNBC specimens substantiated that PRMT1-mediated methylation of PHGDH, PFKFB3, and PKM2 correlates with chemoresistance and that metabolites required for methylation and fatty acid synthesis are enriched in TNBC. Together, these results suggest that enhanced de novo fatty acid synthesis mediated by coordinated protein arginine methylation and protein S-palmitoylation is a therapeutic target for overcoming chemoresistance in TNBC.

Significance:
PRMT1 promotes chemoresistance in TNBC by methylating metabolic enzymes PFKFB3, PKM2, and PHGDH to augment de novo fatty acid synthesis, indicating that targeting this axis is a potential treatment strategy.
Cavaleiro das armas escuras: análise psicolinguística da capacidade persuasiva de Adolf Hitler em uma de suas prédicas políticas
Authors: Lopes Viviane Faria , Ataídes Thaís Hadassa Ferraz 
Published: February 2024

El objetivo principal de esta investigación fue analizar la pericia de inducción que pueden presentar los discursos de los psicópatas para convencer a los interlocutores. Tomando como objetivo central de análisis el sermón La campaña Winter Relief, procunc
iado por el dictador Adolf Hitler, se evaluó tanto su comunicación persuasiva, en el uso hábil e intencional del lenguaje, como la manipulación depredadora imperante en dichos sujetos disociales. Estudiosos del lenguaje, así como investigadores de la mente humana, apoyaron la investigación realizada para promover un análisis psicolingüistico de que una comunicación con intenciones manipulativas puede promover sobre la conducta de los receptores.
Influence of Foehn Winds of Truong Son Mountains on the High Temperatures Observed in North-Central Vietnam during 31 May–5 June 2017
Authors: Kusaka Hiroyuki , Imai Yuma , Kobayashi Hiroki , Doan Quang-Van , Ngo-Duc Thanh 
Published: February 2024

Abstract
North-central Vietnam often experiences high temperatures. Foehn winds originating from the Truong Son Mountains (also known as Laos winds) are believed to contribute to abnormally high temperatures; however, no quantitative research has focused on foehn warming in Vietnam. In this study, we conducted numerical simulations using the Weather Research and Forecasting (WRF) Model to investigate the contribution of foehn warming to abnormally high temperatures in north-central Vietnam in early June 2017. Generally, May–June is the monsoon period in Vietnam. Consequently, foehn warming during this season is thought to be mainly caused by latent heating and precipitation mechanism. However, the primary factor in the cases covered in this study was foehn warming with an isentropic drawdown mechanism. Diabatic heating with turbulent diffusion and sensible heat flux from mountain slopes also plays significant roles. The warming effect of the foehn winds on the temperatures during the events was approximately 2°–3°C. It was concluded that the high temperature events from 31 May to 5 June 2017 were caused by synoptic-scale warm advection and foehn warming. Sensitivity experiments were conducted on the WRF Model, utilizing three atmospheric boundary layer turbulence schemes (YSU, ACM2, and MYNN), consistently yielding results for simulated temperature and relative humidity. The wind speed bias for the MYNN scheme was found to be lower than that of the other schemes. However, this study did not delve into the underlying reasons for these differences. The optimal performance of each scheme remains an open question.

Significance Statement
It was hypothesized that north-central Vietnam often experiences high temperatures owing to foehn winds (also known as Laos winds) descending from the Truong Son Mountains. This study conducted numerical experiments to validate this hypothesis and investigate the associated mechanisms of foehn winds in this region. Surprisingly, despite the monsoon season, the isentropic drawdown mechanism without precipitation effects provides the primary explanation for the high temperatures caused by foehn winds in north-central Vietnam, and not the latent heating and precipitation mechanism with precipitation effects that researchers expected. The results of this study contribute to better prediction of high temperatures in this region and improve our understanding of foehn winds in tropical monsoon climate zones.
The Impact of Wind on Precipitation Measurements from a Compact Piezoelectric Sensor
Authors: Chinchella Enrico , Cauteruccio Arianna , Lanza Luca G. 
Published: February 2024

Abstract
The measurement accuracy of an electroacoustic precipitation sensor, the Vaisala WXT520, is investigated to quantify the associated wind-induced bias. The device is widely used as a noncatching tool for measuring the integral features of liquid precipitation, specifically rainfall amount and intensity. A numerical simulation using computational fluid dynamics is used to determine the bluff-body behavior of the instrument when exposed to wind. The obtained airflow velocity patterns near the sensor are initially validated in a wind tunnel. Then, the wind-induced deviation and acceleration/deceleration of individual raindrop trajectories and the resulting impact on the measured precipitation are replicated using a Lagrangian particle tracking model. The sensor’s specific measurement principle necessitates redefining catch ratios and the collection efficiency in terms of the resulting kinetic energy and quantifying them as a function of particle Reynolds number and precipitation intensity, respectively. Wind speed and direction and drop size distribution have been simulated across various combinations. The results show that the measured precipitation is overestimated by up to 400% under the influence of wind. The presented adjustment curves can be used to correct raw rainfall measurements taken by the Vaisala WXT520 in windy conditions, either in real time or as a postprocessing function. The magnitude of the adjustment at any operational aggregation level largely depends on the local rainfall and wind regimes at the site of measurement and may have a strong impact on applications in regions where wind is frequent during low- to medium-intensity precipitation.
Exacerbation of thromboinflammation by JAK2
V617F mutation worsens the prognosis of cerebral venous sinus thrombosis
Authors: Bourrienne Marie-Charlotte , Le Cam Duchez Véronique , Faille Dorothée , Farkh Carine , Solo Nomenjanahary Mialitiana , Gay Juliette , Loyau Stéphane , Journé Clément , Dupont Sébastien , Ollivier Véronique , Villeval Jean-Luc , Plo Isabelle , Edmond Valérie , Jandrot-Perrus Martine , Labrouche-Colomer Sylvie , Cassinat Bruno , Verger Emmanuelle , Desilles Jean-Philippe , Ho-Tin-Noé Benoît , Triquenot Bagan Aude , Mazighi Mikaël , Ajzenberg Nadine 
Published: February 2024

Abstract
Cerebral venous sinus thrombosis (CVST) is an uncommon venous thromboembolic event accounting for &lt;1% of strokes resulting in brain parenchymal injuries. JAK2V617F mutation, the most frequent driving mutation of myeloproliferative neoplasms, has been reported to be associated with worse clinical outcomes in patients with CVST. We investigated whether hematopoietic JAK2V617F expression predisposes to specific pathophysiological processes and/or worse prognosis after CVST. Using an in vivo mouse model of CVST, we analyzed clinical, biological, and imaging outcomes in mice with hematopoietic-restricted Jak2V617F expression, compared with wild-type Jak2 mice. In parallel, we studied a human cohort of JAK2V617F-positive or -negative CVST. Early after CVST, mice with hematopoietic Jak2V617F expression had increased adhesion of platelets and neutrophils in cerebral veins located in the vicinity of CVST. On day 1, Jak2V617F mice had a worse outcome characterized by significantly more frequent and severe intracranial hemorrhages (ICHs) and higher mortality rates. Peripheral neutrophil activation was enhanced, as indicated by higher circulating platelet–neutrophil aggregates, upregulated CD11b expression, and higher myeloperoxydase plasma level. Concurrently, immunohistological and brain homogenate analysis showed higher neutrophil infiltration and increased blood-brain barrier disruption. Similarly, patients with JAK2V617F-positive CVST tended to present higher thrombotic burden and had significantly higher systemic immune-inflammation index, a systemic thromboinflammatory marker, than patients who were JAK2V617F-negative. In mice with CVST, our study corroborates that Jak2V617F mutation leads to a specific pattern including increased thrombotic burden, ICH, and mortality. The exacerbated thromboinflammatory response, observed both in mice and patients positive for JAK2V617F, could contribute to hemorrhagic complications.
Dual harm among patients attending a mental health unit in Uganda: a hospital based retrospective study
Authors: Favina Alain , Abaatyo Joan , Kaggwa Mark Mohan 
Published: February 2024

Abstract
Background
Dual harm encompasses the complex interplay of the co-occurrence of self-harm and aggression. Individuals with dual harm may display a more hazardous pattern of harmful behaviors like homicide-suicide compared to people with sole harm. This study aimed to examine the presence of dual harm among general psychiatry inpatients in a mental health unit in Uganda.

Methods
A retrospective chart review of 3098 inpatients from January 2018 to December 2021. Dual harm reported experience at admission was based on experiences of self-harm with harm to people or property or both. Logistic regression assessed the association between dual harm and sociodemographics and clinical characteristics.

Results
A total of 29 (1%) patients experienced dual harm, with five having experienced self-harm with both harm to others and property, 23 with harm to people, and one with harm to property. Dual harm was statistically significantly associated with the male gender at bivariate analysis. However, there were no statistically significant factors associated with dual harm at multivariate analysis or sensitivity analysis with the specific types of dual harm.

Conclusion
General psychiatry inpatients in Uganda experience dual harm before admission at lower prevalence than in previous literature. However, no investigated sociodemographic and clinical factors could explain these experiences. Further studies looking at dual harm are warranted to understand these unfortunate experiences with serious consequences among patients in Uganda.
Health system utilization and perceived quality among adults in Lao PDR: evidence from a nationally representative phone survey
Authors: Aryal Amit , Clarke-Deelder Emma , Phommalangsy Souksanh , Kounnavong Sengchanh , Fink Günther 
Published: February 2024

Abstract
Background
The World Health Organization (WHO) defines quality health services as being effective, safe, people-centered, timely, equitable, integrated and efficient. It is critical to understand people’s perspectives and care experiences to measure progress against these goals. However, many low- and middle-income governments do not routinely collect such information. In this study, we aim to measure health systems performance from the perspective of the adult population of users and non-users in Lao PDR.

Methods
Using the People’s Voice Survey (PVS), a novel phone-based survey designed to integrate people’s voices into primary care performance measurement, we conducted a cross-sectional survey of the general adult (18+) population in Lao PDR in 2022. We analyzed health care utilization patterns, user-reported quality of care, and coverage of key preventive health services. Data from the most recent MICS survey was used to create sampling weights generating nationally representative estimates.

Results
A total of 2007 adults completed interviews in approximately 3.5 months. About two thirds (65%) of respondents reported visiting a health facility in the past year and, of these, the majority (61%) visited a hospital as opposed to a health center or clinic. Among those that recently visited health facilities, 28% rated their experience as “poor” or “fair”. 16% had unmet need for care and 12% reported discrimination during treatment in the past year. 12% of women over 50 years old reported receiving a mammogram and 59% of adults reported receiving blood pressure screening in the previous year.

Conclusions
The study presents data from the first nationally representative survey in Lao PDR to measure health system performance. The results indicate that, despite progress towards universal coverage of health insurance in Lao PDR, significant gaps remain, particularly with respect to bypassing of primary care facilities, significant unmet need for care, experiences of discrimination, and overall low perceptions of quality of care.
Teaching nontechnical skills in the undergraduate education of health care professionals: a nationwide cross-sectional study in Hungary
Authors: Nagy Tamás , Fritúz Gábor , Gál János , Székely Andrea , Kovács Enikő 
Published: February 2024

Abstract
Background
The aim of our cross-sectional study was to evaluate the current situation and curriculum of nontechnical skills (NTS) training in the undergraduate education of health care professionals in Hungary.

Methods
All institutes with relevant NTS training in Hungarian faculties of medicine and faculties of health sciences were asked to fill out a 19-item questionnaire. Descriptive statistics were performed, and the characteristics of NTS teaching and non-NTS teaching institutes were compared. The independent predictors of teaching NTS in a particular institute were identified with multiple logistic regression.

Results
Seventy-seven institutes responded (52% response rate), of which 66% trained NTS. The most frequent method of NTS training is talking about them during a practice or lecture, and less than half of NTS respondents use simulation. The most frequent cause of not teaching NTS is a lack of human or technical resources. The type of faculty (p = 0.025), academic year (p = 0.001), field of medicine (p = 0.025), and importance of teamwork (p = 0.021) differed between NTS and noNTS institutes. Teaching students in academic year two represented the only independent predictor of NTS education (p = 0.012).

Conclusions
Our findings show that the undergraduate curriculum of Hungarian universities includes some type of NTS education; however, this education requires further development.
Identification of risk factors and development of a predictive model for chronic kidney disease in patients with obesity: a four-year cohort study
Authors: Zhang Haixia , Zhang Yue , Gao Wenxing , Mu Yiming 
Published: February 2024

Abstract
Objective
The sneaky onset and dismal prognosis of chronic kidney disease (CKD) make it an important public health issue. Obesity-related kidney illness has garnered more attention in recent times. Establishing and validating a risk prediction model for chronic renal illness in overweight or obese adults was the goal of this investigation.

Methods
Data from the China Health and Retirement Longitudinal Study were used for analysis. The definition of CKD was reduced renal function (eGFR < 60 mL/min/1.73 m²), while overweight and obesity were characterized through a body mass index exceeding 24 kg/m². The dataset was divided into derivation and validation cohorts using a 7:3 ratio. With respect to the derivation cohort, we constructed a prediction model using LASSO analysis and multivariate logistic regression. The model’s performance was evaluated using Hosmer-Lemeshow tests, calibration curves, decision curve analysis, and receiver operating characteristic (ROC) curves. The validation cohort’s model was subjected to additional assessment.

Results
The study was based on survey data from 2011 to 2015 and comprised 3246 individuals who were overweight or obese, with 2274 being part of the derivation cohort and 972 being part of the validation cohort. The research constructed a prediction model that included age, sex, fasting blood glucose, glycated hemoglobin, triglyceride, hypertension, and BMI. The validation cohort’s area under the ROC curve was 0.812 (95% CI = 0.763, 0.859) while the derivation cohort’s was 0.789 (95% CI = 0.754, 0.831). Hosmer-Lemeshow tests were utilized to evaluate the model’s accuracy in the validation and derivation cohorts (P = 0.681 and 0.547, respectively). The calibration curve showed a high level of consistency between the actual observations and the projected outcomes. According to decision curve analysis, the model offered significant net advantages.

Conclusions
The forecasting model established in this research has predictive value for CKD in patients with overweight or obesity. These findings could help doctors conduct early detection and intervention in clinical practice and further improve patient prognosis.