bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tulane Virus Inactivation in 3D Food Ink Under Various Storage Conditions: A Pre- and Post-Printing Analysis
Authors: Hamilton Allyson N. , Gibson Kristen E. 
Published: February 2024

Abstract

3D food printers facilitate novel customization of the physicochemical properties of food. This study aimed to investigate the impact of storage conditions on the inactivation of the human norovirus surrogate, Tulane virus (TuV), within 3D printed foods. TuV-inoculated protein cookie food ink (~4 log PFU/g) was distributed into 18 3D food printer capsules (50g each); half immediately underwent extrusion. Storage of the capsules and printed food products at 20°C (0, 6, 12, and 24h), 4°C (0, 1, 3, and 5d), and -18°C (0, 1, 3, and 5d) was completed before analysis for TuV via plaque assays in addition to aerobic plate count, yeast and mold counts, and pH and water activity (aw) measurements. A significant 3-way interaction effect was observed between time, temperature, and storage method (capsule/print) (p = 0.006). Significant findings include: (1) a greater reduction in virions was observed in capsules after 24h at 20°C and (2) a substantial reduction in virions at 4°C from day 0 to day 1 was observed, independent of storage method. Microbial indicators remained steady across temperatures, with storage temperature significantly impacting pH and aw. A significant two-way interaction effect (p = 0.006) was found between microorganism type (yeast/aerobic counts), and temperature. This research seeks to provide insights for the food industry and regulatory bodies in crafting guidelines for the safe storage and handling of 3D printed foods and inks.
Longitudinal association between cumulative ecological risk and eating disorders among Chinese adolescents during the COVID-19 pandemic: A Moderated Mediation Model
Authors: Zheng Meijuan 
Published: February 2024

Abstract
Background
The World Health Organization declared the ongoing COVID-19 outbreak a global pandemic on March 11, 2020. COVID-19 profoundly affects the work and life of individuals, and adolescents are no exception. Adolescents may experience risks from various sources, such as family and school; however, there is limited understanding of the mechanisms that connect these factors during the COVID-19 pandemic. This study aimed to investigate how cognitive avoidance mediates and intentional self-regulation moderates the link between cumulative ecological risk and adolescents’ eating disorders during the COVID-19 pandemic.
Methods
A sample of 769 Chinese adolescents completed questionnaires, including the Cumulative Ecological Risk Questionnaire, the Cognitive Avoidance Questionnaire, the Intentional Self-Regulation Questionnaire, and the Eating Attitude Test Questionnaire.
Result
Cumulative ecological risk had a direct predictive effect on eating disorders among Chinese adolescents. Cognitive avoidance partially mediated the link between cumulative ecological risk and eating disorders among Chinese adolescents. Intentional self-regulation moderated both the direct and indirect effects between cumulative ecological risk and eating disorders among Chinese adolescents.
Conclusion
Cumulative ecological risk and cognitive avoidance both increase the likelihood of Chinese adolescents’ eating disorders during the COVID-19 pandemic. And, intentional self-regulation serves as a protective factor in the relationship between cumulative ecological risk and cognitive avoidance in eating disorders.
Identification of three-gene signature to diagnose rheumatoid arthritis through WGCNA and machine learning methods
Authors: WU Ying Kai , Liu Cai-De , liu Chao , WU ying kai , Xie Zong-Gang 
Published: February 2024

Abstract

Background
Rheumatoid arthritis(RA)is a systemic immune-related disease characterized by synovial inflammation and destruction of joint cartilage.The pathogenesis of RA remains unclear,and there is an urgent need to discover new diagnostic markers with high sensitivity and specificity.The aim of this study was to identify new potential biomarkers in the synovium for diagnosing rheumatoid arthritis and to investigate their association with immune infiltration.
Method
We downloaded four datasets containing 51 RA and 36 healthy synovium samples from the Gene Expression Omnibus(GEO)database.Differentially expressed genes(DEGs)were identified with the help of R program.Then various enrichment analysis were conducted.Subsequently,WGCNA,random forest(RF),support vector machine-recursive feature elimination(SVM-RFE),least absolute shrinkage and selection operator(LASSO)were used to identify the hub genes for RA diagnosis.Receiver operating characteristic curves(ROC)and nomogram models were used to validate the specificity and sensitivity of hub genes.Additionally,we analyzed the infiltration levels of 28 immune cells in the expression profile and their relationship with hub genes using single-sample gene set enrichment analysis (ssGSEA).
Results
Three hub genes(RRM2,DLGAP5 and KIF11)were identified through WGCNA,Lasso,SVM-RFE and RF algorithms.These hub genes showed the strong correlation with T cells,Natural killer cells and Macrophage cells indicated by the analysis of immune cell infiltration.
Conclusion
A nomogram model for the diagnosis of RA based on RRM2,DLGAP5 and KIF11 has been established,providing diagnosis and treatment targets of RA.
Addressing the challenges of missed parathyroid glands in ultrasonography for secondary hyperparathyroidism.
Authors: Chou Shen-En , Yeh Cheng-Hsi , Chi Shun-Yu , Chou Fong-Fu , Wu Yi-Ju , Chang Yen-Hsiang , Chan Yi-Chia 
Published: February 2024

Abstract
Background
Preoperative localization plays an important role in secondary hyperparathyroidism (SHPT) surgery. The advantages of neck ultrasound (US) include high availability and low cost. However, the reported sensitivity of US is 54–76%, and the reason for missed PG on US has been rarely addressed.
Methods
Fifty-four patients who were diagnosed with renal SHPT from September 2020 to March 2022 were included in this retrospective study. Preoperative localization included surgeon-oriented US and technetium 99m-sestamibi single-photon-emission-computed tomography/computed tomography (SPECT/CT).
Results
A total of 212 parathyroid glands (PGs) were pathologically confirmed, resulting in success rate of 96.2% (52/54). Using echo, 193 (91.0%) PGs were accurately localized, while 19 (9.0%) glands were not identified, including those in ectopic positions (n = 12, at thymus or intra-thyroid or others), of a small size (< 1 cm, n = 6), or overlapping with an ipsilateral PG (n = 1). US accurately detected four PGs in 36 (66.7%) patients, while SPECT/CT localized four glands in 19 (35.2%) patients. Although the number of US-detectable PGs was not associated with success rate, it showed significant negative correlation with surgical time (rs=-0.459, P = 0.002).
Conclusion
US detected four glands in 66% of SHPT patients with a sensitivity of 90% for localization. Ectopic position and small size were the most common reasons of failing to detect PG on US. Complete preoperative echo localization might shorten the operating time.
Cis/Etop chemotherapy as a ray of hope in mixed adeno-neuroendocrine carcinoma of colon
Authors: Rasta Sara , Rashidian Maryam , Bastan Fatemeh , Rajabnia Mohsen 
Published: February 2024

Abstract
Background: Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare pathological diagnosis reported by the World Health Organization in 2010 for the first time. Neuroendocrine tumors are characterized by rapid progression.
Case Presentation: A 70-year-old man who complained about anemia, diarrhea and significant weight loss did colonoscopy. Biopsy showed a poorly differentiated carcinoma. Biopsy upon surgical rectosigmoid resection revealed a mixed neuroendocrine-adenocarcinoma. Chemotherapy with fofox6 regimen was started but after eight months, tumor relapsed in anastomosis site of surgery involving para aortic lymph nodes and growth of tumor had led to gastrointestinal obstruction symptom. We did relieving surgery and changed chemotherapy regimen to cisplatin/etoposide regimen. He responded to the treatment well, and the mass almost disappeared.
Conclusions: The optimal strategy for management of mixed endocrine tumor is variable as they present rare and atypical. Adjuvant chemotherapy play a critical role in the treatment and survival due to MANEC aggressive progression and recurrence. Our data derived from this case may be essential for the diagnosis, treatment, and management of MANEC patients’ symptoms.
Low and Medium Voltage Distribution Network Planning with Distributed Energy Resources: A Survey
Authors: Pham Tan Nhat , Shah Rakibuzzaman , Dao Minh N. , Sultanova Nargiz , Islam Syed 
Published: February 2024

Abstract

The penetration of distributed energy resources (DERs) such as photovoltaic systems, energy storage systems, and electric vehicles is increasing in the distribution system. The distinct characteristics of these resources, e.g., volatility and intermittency, introduce complexity in operation and planning of the distribution system. This paper first summarized the physical characteristics and morphological evaluation of the current and future distribution networks. Then, the impact of these changes on system operation and planning is outlined. Next, the tools, methods, and techniques for energy forecasting, optimal planning, and distribution system state estimation are reviewed and discussed, along with the challenges. As the main contributions, this research systematically organized the published works and assessed the relevant milestones regarding distribution system planning with DERs and emerging technologies. Finally, the key research directions in this domain are outlined.
Effect of Calcium Silicate on Mechanical and Frictional Wear Behaviors of AA7075 Hybrid Composites: A Statistical Analysis
Authors: K Gnanasekaran , D Ananthapadmanaban , R Franklin Issac 
Published: February 2024

Abstract
Recently, Aluminium Alloy (AA) 7075 based Metal Matrix Composites (MMC) have been widely used in aerospace applications due to their high strength to density ratio, but it mostly fails in tribo applications. The addition of ceramic material like Al2O3 to the AA7075 Hybrid Composites (AHCs) has improved their wear and thermal properties, but the density of the AHCs has also increased. In this regard, it is essential to identify a low-density ceramic to improve the wear resistance of the AHCs without affecting their density or mechanical strength. For the study on the effect of Ca2SiO4 on the AHCs, the AHCs/Al2O3/Ca2SiO4 samples were successfully fabricated and tested in terms of mechanical and frictional wear properties. The fabricated AHCs had a relative density of around 3.54±0.05% higher than AA7075, which is due to the impact of high-density ceramic Al2O3 reinforcement. The lowest specific wear rate is obtained for the AHCs/Al2O3(10 wt. %)/Ca2SiO4(8 wt. %) at the high applied load and the low sliding velocity, which is around 1.44 x 10-6 g/Nm, and its corresponding CoF is 0.158. Finally, the wear maps are developed from the contour plots of responses to identify the cause and consequences of the wear mechanism during the dry sliding of AHCs.
Risk prediction model for postoperative brain metastasis in IIB-IIIB non-small cell lung cancer: based on radiomics and clinicopathology
Authors: yang Lu , Liao Chengde , Ouyang Zhiqiang , Li Qinqing , Huang Yunchao , yang Jun 
Published: February 2024

Abstract

Purpose
To develop and validate a model based on radiomics and clinicopathological features for predicting postoperative brain metastasis (BM) in stage IIB-IIIB non-small cell lung cancer (NSCLC) patients.
Materials and methods
A total of 333 NSCLC patients operated from October 2015 and December 2019 with postoperative pathological stage IIB-IIIB were included, which were randomly divided into a training and validation cohort. The intratumoral and peritumoral radiomics features from preoperative CT image were extracted and selected using the least absolute shrinkage and selection operator (LASSO). The independent clinical predictors of BM were identified by univariate and multivariate Cox analysis. The radiomics model, clinical model and radiomics combined clinicopathological model were constructed with six different algorithms. Subsequently, we constructed a dynamic nomogram. The performance of the model was evaluated by the area under the curve (AUC), sensitivity, specificity, calibration curve and decision curve analysis (DCA).
Results
The radiomics model combining intratumoral and peritumoral radiomics features exhibited great predictive performance for BM prediction, with an AUC of 0.888–0.928 in the training cohort and 0.838–0.894 in the validation cohort. The model including the intra- and peritumoral radiomics, T stage, histological type, spiculation and other metastatic sites yielded AUC of 0.947–0.979 in the training cohort and 0.847–0.926 in the validation cohort, with good calibration for all algorithms (p > 0.05). DCA revealed that the combined model obtained a greater net benefit.
Conclusion
The model that integrates radiomics features with clinicopathological features could aid in early-stage prediction of postoperative BM risk in stage IIB-IIIB NSCLC patients. Dynamic nomogram provides great convenience for clinicians to manage patients.
Donor/recipient Rh-mismatched allogeneic hematopoietic stem cell transplantation: transfusion strategy and allo-immunization to red blood cell antigens
Authors: XHAARD Aliénor , Floch Aline , Robin Marie , de Fontbrune Flore Sicre , Michonneau David , Kaphan Eleonore , Prata Pedro , Ruggiu Mathilde , Socie Gerard , Traineau Richard , de Latour Regis Peffault , Lepretre Anne-Claire 
Published: February 2024

Abstract

In the case of donor/recipient rhesus (Rh)-incompatibility after allogeneic hematopoietic stem cell transplantation (alloHSCT), the transfusion policy in France is to transfuse red blood cells (RBC) in the donor’s Rh phenotype from the day of transplantation, leading to a risk of allo-immunization, either of donor or recipient origin. In this single-center retrospective study, the incidence of donor/recipient Rh incompatibility was 7.1% over an eight-year period including 1 012 alloHSCT. Six of 58 evaluable patients (10.3%) developed alloantibodies to RBC antigens within one year of alloHSCT. None of these allo-immunizations were directed against the donor-mismatched Rh antigens and none of them could have been prevented by the transfusion of recipient and donor Rh-compatible RBC units. None of these allo-immunizations led to immune-mediated hemolytic anemia. These results show that, in the context of donor/recipient Rh incompatibility, the transfusion of packed RBC units in the donor’s Rh phenotype from the day of alloHSCT is feasible and not associated with a high risk of allo-immunization. The generalization of this strategy could also be discussed even when donor and recipient Rh phenotypes could be respected, to allow the preservation of units of infrequent phenotypes for other indications.
Options for Future European Reusable Booster Stages: Evaluation and Comparison of VTHL and VTVL Return Methods
Authors: Stappert Sven , Dietlein Ingrid , Wilken Jascha , Bussler Leonid , Sippel Martin 
Published: February 2024

Abstract

In the past the majority of system studies on reusable space transportation performed within Europe focused on concepts relying on lift-generating wings for recovery. Recently, vertically landing concepts similar to those deployed successfully by SpaceX have moved to the center of technical attention.
Both recovery and landing strategies have their pros and cons and it is not obvious what would be a sound choice for Europe. Therefore, the German Aerospace Center DLR initiated a parametric system study, named ENTRAIN, that evaluates the impact of different return options on the launcher design on a technical level: the vertical take-off, vertical landing method (VTVL) as used by SpaceX compared to the vertical take-off, horizontal landing (VTHL) method as used for the Space Shuttle. Within this study, launchers were designed using different propellant combinations, staging velocities and engine cycles. The designed launchers are evaluated in this paper regarding performance, technical difficulties, operational aspects, size, mass and complexity.
A Concept-Aware Explainability Method for Convolutional Neural Networks
Authors: Gurkan Mustafa Kagan , Vural Fatos Yarman , Arica Nafiz 
Published: February 2024

Abstract

Although Convolutional Neural Networks (CNN) outperform the classical models in a wide range of Machine Vision applications, their restricted interpretability and their lack of comprehensibility inreasoning, generates many problems such as security, reliability and safety. Consequently, there is a growing need on research to improve explainability and address their limitations.
In this paper, we propose a concept-based method, called Concept-Aware Explainability (CAE) to provide a verbal explanation for the predictions of pre-trained CNN models. A new measure, called detection score mean, is introduced to quantify the relationship between the filters of the model and a set of pre-defined concepts. Based on the detection score mean values, we define sorted lists of Concept-Aware Filters (CAF) and Filter-Activating Concepts (FAC). These lists are used to generate explainability reports, where we can explain, analyze, and compare models in terms of the concepts embedded in the image. The proposed explainability method is compared to the state-of-the-art methods to explain Resnet18 and VGG16 models, pre-trained on ImageNet and Places365-Standard datasets. Two popular metrics, namely, number of unique detectors and numberof detecting filters, are used to make a quantitative comparison. Superior performances are observed for the suggested CAE, when compared to Network Dissection (NetDis) [1] and Net2Vec [2] methods.
Economic value estimation of public support for the Kinmen Horseshoe Crab conservation
Authors: Hong Chun-Fu , Lee Chun-Hung , Lee Yi-Hsing 
Published: February 2024

Abstract
With the rapid decline in horseshoe crab population in Taiwan, the balance between economic development and conservation has become an important issue. Based on the random utility model of horseshoe crab conservation and economic development, we evaluated public support and willingness to pay (WTP) for horseshoe crab conservation and economic development. Our results showed that the public supported (1) horseshoe crab conservation and economic development together; (2) the inclusion of conservation concepts in elementary and middle school curricula materials and the training of conservation volunteers; (3) restoring the natural habitat of horseshoe crabs and listing them as a protected animal; and (4) issuing licensing requirements for horseshoe crab harvesting to allow the coexistence of conservation and economic development; moreover, we found that (5) female residents who have participated in conservation-related activities prioritize ecological conservation over economic development.
Continuous flow aerobic granular sludge: recent developments and applications
Authors: Yu Cheng , Wang Kaijun 
Published: February 2024

Abstract

Aerobic granular sludge (AGS) in continuous-flow reactors (CFRs) has attracted significant interest, with notable progress in research and application over the past two decades. Cumulative studies have shown that AGS-CFRs exhibit comparable morphology, settleability, and pollutant removal efficiency to AGS cultivated in sequencing batch reactors, despite their smaller particle sizes. Shear force and selection pressure are the primary drivers of granulation. While not mandatory for granulation, feast/famine conditions play a crucial role in ensuring long-term stability and nutrient removal. Additionally, bioaugmentation can facilitate the granulation process. Furthermore, this paper comprehensively assesses the application of AGS-CFRs in full-scale wastewater treatment plants (WWTPs). Currently, AGS-CFRs have been implemented in nine WWTPs, encompassing two distinct processes. Hydrocyclone-based densified activated sludge significantly enhances sludge density, settleability, and biological phosphorus removal efficiency, thus increasing treatment capacity. The microaerobic–aerobic configuration with internal separators can induce granulation, ensuring long-term stability, eliminating the need for external clarifiers, and reducing land and energy requirements. This review demonstrates the high potential of AGS-CFRs for intensifying existing WWTPs with minimal retrofitting needs. However, further research is required in granulation mechanisms, long-term stability, and nutrient removal to promote the widespread adoption of AGS.
Relationship between Compound α-Ketoacid and Microinflammation in
Patients with Chronic Kidney Disease
Authors: Chen Zaobin , Lin Yongda , Wang Jiali , Yao Kaijin , Xie Yina , Chen Xiutian , Zhou Tianbiao 
Published: February 2024

Abstract:
Chronic kidney disease (CKD) refers to the presence of structural or functional abnormalities in the
kidneys that affect health, lasting for more than 3 months. CKD is not only the direct cause of global incidence
rate and mortality, but also an important risk factor for cardiovascular disease. Persistent microinflammatory
state has been recognized as an important component of CKD, which can lead to renal fibrosis and loss of renal
function, and plays a crucial role in the pathophysiology and progression of the disease. Simultaneously,
compound α-Ketoacid can bind nitrogen-containing metabolites in the blood and accelerate their excretion
from the body, thereby reducing the level of metabolic waste, alleviating gastrointestinal reactions in patients,
and reducing the inflammatory response and oxidative stress state of the body. Compoundα-Ketoacid contains
amino acids required by CKD patients. In this review, we explore the relationship between compound α-Ketoacid
and microinflammation in patients with CKD. The review indicated that compound α-Ketoacid can improve
the microinflammatory state in CKD patients by improving the nutritional status of CKD patients, improving
patient's acid-base balance disorder, regulating oxidative stress, improving gut microbiota, and regulating
abnormal lipid metabolism.