bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sedimentology and sequence stratigraphy of shallow and deeper marine Miocene deposits: A case study from the St. Paul and Gebel El‐Zeit blocks, Gulf of Suez, Egypt
Authors: El‐Azabi Mounir H. 
Published: December 2023

AbstractMarginal and deeper marine facies typify the Miocene exposures along the western margin of the Gulf of Suez rift basin. The stratigraphic setting of these facies is a subject of debate and confusing at best. Integrative sedimentological and sequence stratigraphic study of successions exposed in the St. Paul and El‐Zeit blocks provides insight into the lateral relationships between the two facies and their evolution, a topic that is not fully understood. The St. Paul block, located at the basin margin, has thin shallow marine facies, while the succession of El‐Zeit block, situated near the basin axis, consists of basal conglomerates, thin shallow marine carbonates, thick deeper marine shale and marginal evaporites. The facies architecture of these successions is interpreted as belonging to two different depositional models: a fan‐delta/lagoon system followed upwards by an alluvial fans/sabkha‐tidal flat system in the St. Paul hangingwall basin, and carbonate–siliciclastic–evaporite systems on the hangingwall dip‐slope ramp of El‐Zeit block. These models may help understanding the sedimentary history of other similar blocks in the rift basin. The studied facies show many striking features such as deposition during tilting of fault block, abrupt facies and thickness variations, coarse clastic shedding, erosion channel filling, onlapping of high standing blocks and evaporite accumulation. These features are the result of major tectonic events that triggered the formation of unconformities at different hierarchical levels during the late early to middle Miocene. These unconformities subdivide the Miocene facies into five depositional sequences separated by basin‐wide erosional boundaries. This division greatly improves the age control of marginal marine facies. It affords new insight into the evolution of marginal marine facies along the western margin of the basin in relation to deeper facies in the basin centre. Facies and thickness changes in these tectonically induced sequences indicate that basin floor irregularities, subsidence rates, climatic changes, variable sediment influx, sea‐level/brine‐level changes and basin isolation/connection to the Mediterranean Sea are also important factors responsible for their evolution.
Long‐term effects of a community‐based oral health intervention for young children in the Netherlands: A 5‐year follow‐up
Authors: Verlinden Deborah Ashley , Schuller Annemarie A. , Vermaire Jan H. , Reijneveld Sijmen A. 
Published: December 2023

AbstractObjectivesThe aim of this study was to assess whether referral of parents of 6 months old children by a well‐child care (WCC) clinic medical practitioner for an early first dental visit combined with the Non Operative Caries Treatment and Prevention (NOCTP) approach in dental practices was effective to maintain oral health in children.MethodsThe study was conducted as a quasi‐experimental comparative pre‐post trial with a baseline measurement before the intervention. In total 1347 children were allocated at the age of 6 months and 306 children (intervention group: n = 166; care as usual (CAU) group: n = 140) underwent an oral examination at 5 years of age and their parents completed a questionnaire. Nonparametric tests and Hurdle models were used to determine differences in caries experience between the intervention and CAU groups.ResultsChildren in the intervention group had significantly lower caries experience (d1,2,3mfs) than children in the CAU group (Median = 2 vs. 5, r = .15, p < .01). Children in the intervention group had significantly fewer inactive caries lesions compared with children in the CAU group (Median = 2 vs. 3, r = .18, p < .001). No differences were found for dentin caries experience and also no differences for active caries lesions.ConclusionsReferral of parents of newborns for a preventive first dental visit by a WCC medical practitioner combined with NOCTP in dental practices may offer a new opportunity to reduce enamel caries lesions in young children.
Clinical features associated with epilepsy occurrence, resolution, and drug resistance in children with cerebral palsy: A population‐based study
Authors: Feroze Nimra , Karim Tasneem , Ostojic Katarina , Mcintyre Sarah , Barnes Elizabeth H. , Lee Byoung Chan ,   Cerebral Palsy Alliance study group, Dale Russell C. , Gill Deepak , Kothur Kavitha 
Published: December 2023

AbstractAimTo investigate clinicoradiological features associated with epilepsy, its resolution, and drug resistance in children with cerebral palsy (CP).MethodData were gathered from the New South Wales/Australian Capital Territory CP Register, encompassing children with CP born between 2003 and 2015 (n = 1916). Clinical features and the severity of impairments were compared among three groups: children with current epilepsy (n = 604), those with resolved epilepsy by age 5 years (n = 109), and those without epilepsy (n = 1203). Additionally, a subset of the registry cohort attending Children's Hospital Westmead (n = 256) was analysed to compare epilepsy and treatment characteristics between drug‐responsive (n = 83) and drug‐resistant groups (n = 147) using logistic regression and hierarchical cluster analysis.ResultsManual Ability Classification System levels IV and V, intellectual impairment, and vision impairment were found to be associated with epilepsy in children with CP on multivariable analysis (p < 0.01). Moderate to severe intellectual impairment and bilateral spastic CP were independent positive and negative predictors of epilepsy persistence at the age of 5 years respectively (p < 0.05). Microcephaly and multiple seizure types were predictors of drug‐resistant epilepsy (area under the receiver operating characteristic curve of 0.83; 95% confidence interval 0.77–0.9). Children with a known genetic cause (14%) and CP epilepsy surgery group (4.3%) formed specific clinical subgroups in CP epilepsy.InterpretationOur study highlights important clinical associations of epilepsy, its resolution, and treatment response in children with CP, providing valuable knowledge to aid in counselling families and identifying distinct prognostic groups for effective medical surveillance and optimal treatment.What this paper adds

Severe motor and non‐motor impairments in cerebral palsy (CP) increase epilepsy risk.
Epilepsy more likely resolves in bilateral spastic and milder CP impairments.
Epilepsy in CP often manifests at an early age with multiple seizure types and high drug resistance.
Children with a known genetic cause and CP epilepsy surgery group represent distinct clinical subgroups.
The role of psychotic‐like experiences in the association between aberrant salience and anxiety: A psychopathological proposal based on a case–control study
Authors: Merola Giuseppe Pierpaolo , Patti Andrea , Benedetti Davide , Bozza Bernardo , Ballerini Andrea , Ricca Valdo 
Published: December 2023

AbstractAimAberrant salience (AS) and psychotic‐like experiences (PLEs) have been proven to be linked. Moreover, anxiety is a key symptom in psychosis‐prone subjects and most psychotic patients. We propose a model that attempts to interpret the role of PLEs in the association between AS and anxiety among healthy controls and psychotic patients.MethodsDemographic and psychometric data (Aberrant Salience Inventory, Community Assessment of Psychic Experiences, Symptom Check List‐90‐revised) from 163 controls and 44 psychotic patients was collected. Descriptive statistics, correlations, a linear regression model and a mediation analysis with covariates were subsequently performed.ResultsAS correlated with more frequent positive PLEs and higher anxiety levels in both patients and controls. However, positive PLEs' frequency mediated the relationship between AS and anxiety only among controls.ConclusionsPLEs linked to AS appear to induce anxiety among the control group but not among psychotic patients. The progressive loss of both novelty and insight, which may, respectively, impair the somatic emotional reactivity to PLEs and the ability to recognize some bodily phenomena as the embodied correlates of anxiety, is seen as the most probable theoretical explanation.
Experimental and numerical study on the multi‐site fretting fatigue crack initiation of press‐fitted axles
Authors: Zou Lang , Zeng Dongfang , Tian Xu , Jiang Guangyao , Dong Yihui , Zhao Hai , Lu Liantao 
Published: December 2023

AbstractIn this study, fretting fatigue tests were conducted to gather information on both fretting fatigue and fretting wear. Subsequently, an evaluation methodology that combined the Modified Wöhler Curve Method (MWCM) with the theory of critical distance (TCD) was established to investigate multi‐site fretting crack initiation. The results showed that the fretting fatigue damage could be reasonably evaluated using the MWCM equivalent stress σMWCM. σMWCM is greatly influenced by both bulk stress and fretting wear‐induced stress concentration. The stress field close to the wear boundary increased due to the continuous fretting wear, leading to an increase in σMWCM; meanwhile, the bulk stress near the wear boundary decreased as the crack propagated, resulting in a decrease in σMWCM. The combined effect of the fretting crack propagation and wear caused σMWCM, which was located within an annular strip of the axle, to exceed the critical value, causing the multi‐site fretting crack initiation.
Alternative fatigue–creep performance of rock‐backfill composite structure material in mine stopes under high static stress: Disturbed amplitude effect
Authors: Wang Yu , Long Dayu , Yi Xuefeng , Mao Tianqiao 
Published: December 2023

AbstractThis work aims to investigate the dynamic stress amplitude on the mechanical responses of rock‐backfill composite structure material under alternative low‐cycle fatigue loading and creep loading tests. Results show that deformation, damage propagation, and failure pattern are all impacted by the stress amplitude, and volumetric deformation is the largest for a sample subjected to strong stress disturbance. The equivalent lifetime decreases with the increase of disturbed amplitude. A notable positive interaction between the fatigue damage and time‐dependent damage is found, and they promote each other. Additionally, a novel damage evolution model is proposed by the irreversible radial strain, and the model matches well with the testing data. Moreover, post‐test computed tomography imaging reveals that cracks at rock‐backfill interfaces are relatively easy to be stimulated under low stress disturbance, and it is suggested that tension‐splitting failure is more likely to occur within the surrounding rock, and shear failure seems to occur within the cemented tailings backfill for all the tested samples.
Research on university‐based Spanish heritage language programs in the United States: The state of affairs in 2022
Authors: Beaudrie Sara M. , Marrero‐Rivera Anna 
Published: December 2023

AbstractResearch on Spanish heritage language (SHL) education has grown exponentially in the last two decades. The most recent nationwide study on SHL programs in US postsecondary institutions was conducted a decade ago. To continue this line of research, the primary aim of this study is to provide an update about the current state of SHL course offerings at 4‐year universities in the United States. SHL programs can promote academic success for Latinx students who see their language and culture asserted. In turn, valuing their heritage language skills and supporting their language development can help Latinx students expand their multilingual abilities for use with their families and communities, as well as in professional contexts. Results reveal that the last decade (2012–2022) witnessed tremendous increase in the availability of SHL programs, although some of the challenges reported in prior research still remain nationwide.
Impact of obese patients in ovarian cancer surgery on postoperative wound complications: A meta‐analysis
Authors: Huang Xianxia , Du Shengye , Wang Qun , Yang Chenchen , Liu Xueling , Chen Kai , Zhao Yinghui , He Ning , Wang Hongping 
Published: December 2023

AbstractThe effect of obesity on wound‐related outcomes in post‐ovarian cancer patients is not clear. A number of studies on the association of fat with post‐operation injury in ovarian carcinoma have produced contradictory findings. This study aims to conduct a study of the available data to assess the association of obese individuals with significant surgery results in ovarian cancer. We looked up Cochrane Library, Embase, and PubMed for qualifying research on ovarian cancer operations to determine the primary evidence for evaluating the association of obesity with post‐surgical wound injury in ovarian cancer. The odds ratio (OR) was analysed with a fixed effect model if the variability of the study was small; otherwise, the analysis of the data was done with a random effect model. Out of 1259 related trials which were reviewed for eligibility, 6 publications were chosen from 2009 to 2019, 3076 patients who had had an operation for ovarian cancer. Obesity has been linked to an increased rate of wound‐related complications in ovarian cancer operations compared to those without obesity (OR, 0.50; 95% CI, 0.37, 0.69 p < 0.0001). Non‐obesity was significantly less likely to occur with respect to operation time compared to those with obesity (MD, −48.00; 95% CI, −55.33, −40.68 p < 0.00001). There were no statistically significant differences in the rate of haemorrhage after the operation (OR, 0.26; 95% CI, 0.04, 1.57, p = 0.14). Because of the limited number of trials in this meta‐analysis, caution should be exercised in their treatment. More high‐quality research with a large sample is required in order to confirm the findings.
The environment, life expectancy, and growth in overlapping generations models: A survey
Authors: Dugan Anna , Prskawetz Alexia , Raffin Natacha 
Published: December 2023

AbstractIt is widely accepted that environmental and demographic changes will significantly influence the future of our society. In recent years, an increasing number of studies has analyzed the interlinkages among economic growth, environmental factors, and a specific demographic variable, namely life expectancy, applying an overlapping generations framework. The aim of this survey is threefold. First, we review the role of life expectancy and pollution for sustainable growth. Second, we discuss the role of intervening factors like health investment and technological progress as well as institutional settings including government expenditures, tax structures, and inequality. Finally, we summarize policy implications obtained in different models and compare them to each other.
Road crack detection interpreting background images by convolutional neural networks and a self‐organizing map
Authors: Yamaguchi Takahiro , Mizutani Tsukasa 
Published: December 2023

AbstractThe presence of road cracks is an important indicator of damage. Deep learning is a prevailing method for detecting cracks in road surface images because of its detection ability. Previous research works focused on supervised convolutional neural networks (CNNs) without non‐crack features or unsupervised crack analysis with limited accuracies. The novelty of this study is the addition of background classification. By increasing the number of non‐crack categories, CNNs are driven to learn non‐crack features and improve crack detection performances. Non‐crack images are preprocessed, and their features are extracted in an unsupervised way by a deep convolutional autoencoder. A self‐organizing map clusters features to obtain non‐crack categories. This study focusses on classification though the method can be adopted in parallel with the latest segmentation algorithms. Using common road crack datasets, modified deep CNN models significantly improved accuracy by 1%–4% and f‐measure by 3%–8%, compared to previous models. The modified visual geometry group (VGG) 16 showed the top‐level performance, 96% accuracy and 84%–85% f‐measure. The models drastically reduced false detection cases while maintaining their crack detection abilities.
Immune and metabolic perturbations in COVID‐19‐associated pulmonary mucormycosis: A transcriptome analysis of innate immune cells
Authors: Dhaliwal Manpreet , Muthu Valliappan , Sharma Arunima , Raj Khem , Rudramurthy Shivaprakash M , Agarwal Ritesh , Kaur Harsimran , Rawat Amit , Singh Surjit , Chakrabarti Arunaloke 
Published: December 2023

AbstractBackground and ObjectivesThe mechanisms underlying COVID‐19‐associated pulmonary mucormycosis (CAPM) remain unclear. We use a transcriptomic analysis of the innate immune cells to investigate the host immune and metabolic response pathways in patients with CAPM.Patients and MethodsWe enrolled subjects with CAPM (n = 5), pulmonary mucormycosis (PM) without COVID‐19 (n = 5), COVID‐19 (without mucormycosis, n = 5), healthy controls (n = 5) without comorbid illness and negative for SARS‐CoV‐2. Peripheral blood samples from cases were collected before initiating antifungal therapy, and neutrophils and monocytes were isolated. RNA sequencing was performed using Illumina HiSeqX from monocytes and neutrophils. Raw reads were aligned with HISAT‐2 pipeline and DESeq2 was used for differential gene expression. Gene ontology (GO) and metabolic pathway analysis were performed using Shiny GO application and R packages (ggplot2, Pathview).ResultsThe derangement of core immune and metabolic responses in CAPM patients was noted. Pattern recognition receptors, dectin‐2, MCL, FcRγ receptors and CLEC‐2, were upregulated, but signalling pathways such as JAK–STAT, IL‐17 and CARD‐9 were downregulated; mTOR and MAP‐kinase signalling were elevated in monocytes from CAPM patients. The complement receptors, NETosis, and pro‐inflammatory responses, such as S100A8/A9, lipocalin and MMP9, were elevated. The major metabolic pathways of glucose metabolism—glycolysis/gluconeogenesis, pentose phosphate pathway, HIF signalling and iron metabolism‐ferroptosis were also upregulated in CAPM.ConclusionsWe identified significant alterations in the metabolic pathways possibly leading to cellular iron overload and a hyperglycaemic state. Immune responses revealed altered recognition, signalling, effector functions and a pro‐inflammatory state in monocytes and neutrophils from CAPM patients.
Post‐implantation CMR imaging to study biventricular pacing effects on the right ventricle in left bundle branch block patients
Authors: Hopman Luuk H. G. A. , Zweerink Alwin , van de Veerdonk Mariëlle C. , van der Lingen Anne‐Lotte C. J. , Huntelaar Marthe J. , Robbers Lourens F. H. J. , van Rossum Albert C. , Götte Marco J. W. , van Halm Vokko P. , Allaart Cornelis P. 
Published: December 2023

AbstractCardiac resynchronization therapy (CRT) is an established treatment for heart failure patients with left ventricular dysfunction and a left bundle branch block. However, its impact on right ventricular (RV) function remains uncertain. This cardiac magnetic resonance imaging study found that CRT did not improve RV volumes and function, and CRT‐off during follow‐up had an immediate detrimental effect on the RV, which may suggest potential unfavorable RV remodeling with RV pacing during CRT.
Soybean and grapevine rusts accelerate the defoliation rates of host plants
Authors: Primiano Isabela Vescove , Amorim Lilian 
Published: December 2023

AbstractGrapevine leaf rust (GLR) and soybean rust (SBR), caused by Neophysopella tropicalis and Phakopsora pachyrhizi, respectively, may lead to early defoliation of the host, depending on disease severity level. The rate of defoliation is an important parameter in mechanistic models aimed at simulating yield loss, but such knowledge is not available for these rust diseases. This work aimed to (i) relate the temporal dynamics of GLR and SBR to defoliation; and (ii) estimate the relative rates of defoliation and model their relationship with rust severities. Grapevine and soybean plants were inoculated in the field at increasing concentrations of urediniospore suspensions of the respective causal agent. Control plots of the vineyard and the soybean field were protected with sequential fungicide sprays to evaluate natural defoliation. Rust severity (proportion of area affected) of each leaf or leaflet was evaluated every three or four days on 1323 grapevine leaves and 655 soybean leaflets, respectively. The relative rates of defoliation were estimated as the slope parameters of linear regression of the Napierian logarithm of the number of alive leaves or leaflets over time. Defoliation rates in grapevine and soybean incremented logarithmically with the increase of rust severity. Defoliation rates on symptomless grapevine and soybean leaves were 0.018 and 0.05 day−1, respectively, while they averaged 0.033 day−1 on diseased grapevine leaves (rust severity between 5% and 12%), and 0.12 day−1 on diseased soybean leaflets (rust severity between 25% and 60%). Thus, a quantitative relationship was established between rust severity and defoliation on grapevine and soybean.
Synergistic regulation at physiological, transcriptional and metabolic levels in tomato plants subjected to a combination of salt and heat stress
Authors: Li Yankai , Jiang Fangling , Niu Lifei , Wang Ge , Yin Jian , Song Xiaoming , Ottosen Carl‐Otto , Rosenqvist Eva , Mittler Ron , Wu Zhen , Zhou Rong 
Published: December 2023

SUMMARYWith global warming and climate change, abiotic stresses often simultaneously occur. Combined salt and heat stress was a common phenomenon that was severe, particularly in arid/semi‐arid lands. We aimed to reveal the systematic responsive mechanisms of tomato genotypes with different salt/heat susceptibilities to combined salt and heat stress. Morphological and physiological responses of salt‐tolerant/sensitive and heat‐tolerant/sensitive tomatoes at control, heat, salt and combined stress were investigated. Based on leaf Fv/Fm and H2O2 content, samples from tolerant genotype at the four treatments for 36 h were taken for transcriptomics and metabolomics. We found that plant height, dry weight and net photosynthetic rate decreased while leaf Na+ concentration increased in all four genotypes under salt and combined stress than control. Changes in physiological indicators such as photosynthetic parameters and defence enzyme activities in tomato under combined stress were regulated by the expression of relevant genes and the accumulation of key metabolites. We screened five key pathways in tomato responding to a combination of salt and heat stress, such as oxidative phosphorylation (map00190). Synergistic regulation at morphological, physiological, transcriptional and metabolic levels in tomato plants was induced by combined stress. Heat stress was considered as a dominant stressor for tomato plants under the current combined stress. The oxidative phosphorylation pathway played a key role in tomato in response to combined stress, where tapped key genes (e.g. alternative oxidase, Aox1a) need further functional analysis. Our study will provide a valuable resource important for studying stress combination and improving tomato tolerance.