bluuebunny/crossref_metadata_2025_split huggingface dataset:
From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research
Authors: Liu Kailun , Chen Xiaowei , Fan Zhen , Ren Fei , Liu Jing , Hu Baoyang 
Published: February 2025

Abstract
The high failure rates in clinical drug development based on animal models highlight the urgent need for more representative human models in biomedical research. In response to this demand, organoids and organ chips were integrated for greater physiological relevance and dynamic, controlled experimental conditions. This innovative platform—the organoids-on-a-chip technology—shows great promise in disease modeling, drug discovery, and personalized medicine, attracting interest from researchers, clinicians, regulatory authorities, and industry stakeholders. This review traces the evolution from organoids to organoids-on-a-chip, driven by the necessity for advanced biological models. We summarize the applications of organoids-on-a-chip in simulating physiological and pathological phenotypes and therapeutic evaluation of this technology. This section highlights how integrating technologies from organ chips, such as microfluidic systems, mechanical stimulation, and sensor integration, optimizes organoid cell types, spatial structure, and physiological functions, thereby expanding their biomedical applications. We conclude by addressing the current challenges in the development of organoids-on-a-chip and offering insights into the prospects. The advancement of organoids-on-a-chip is poised to enhance fidelity, standardization, and scalability. Furthermore, the integration of cutting-edge technologies and interdisciplinary collaborations will be crucial for the progression of organoids-on-a-chip technology.
Recent advances in epidemiology, pathogenesis, diagnosis, and treatment of inflammatory bowel disease: Insights from the past two years
Authors: Wan Jian , Zhou Jiaming , Wang Zhuo , Liu Dan , Zhang Hao , Xie Shengmao , Wu Kaichun 
Published: February 2025

Abstract
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a chronic inflammation of the gastrointestinal tract with unknown etiology. The cause of IBD is widely considered multifactorial, with prevailing hypotheses suggesting that the microbiome and various environmental factors contribute to inappropriate activation of the mucosal immune system in genetically susceptible individuals. Although the incidence of IBD has stabilized in Western countries, it is rapidly increasing in newly industrialized countries, particularly China, making IBD a global disease. Significant changes in multiple biomarkers before IBD diagnosis during the preclinical phase provide opportunities for earlier diagnosis and intervention. Advances in technology have driven the development of telemonitoring tools, such as home-testing kits for fecal calprotectin, serum cytokines, and therapeutic drug concentrations, as well as wearable devices for testing sweat cytokines and heart rate variability. These tools enable real-time disease activity assessment and timely treatment strategy adjustments. A wide range of novel drugs for IBD, including interleukin-23 inhibitors (mirikizumab, risankizumab, and guselkumab) and small-molecule drugs (etrasimod and upadacitinib), have been introduced in the past few years. Despite these advancements, approximately one-third of patients remain primary non-responders to the initial treatment, and half eventually lose response over time. Precision medicine integrating multi-omics data, advanced combination therapy, and complementary approaches, including stem cell transplantation, psychological therapies, neuromodulation, and gut microbiome modulation therapy, may offer solutions to break through the therapeutic ceiling.
RNA Sequencing Confirms the Pathogenicity of a Novel FHL1 Deletion in a Kinship With Emery–Dreifuss Muscular Dystrophy
Authors: Nagaraj Chinmayee B. , Tian Cuixia , Kushlaf Hani 
Published: February 2025

Abstract
Pathogenic variants in FHL1 are associated with X-linked reducing body myopathy, scapuloperoneal myopathy, myopathy with postural muscle atrophy or Emery–Dreifuss muscular dystrophy type 6. Emery–Dreifuss muscular dystrophy is characterized by joint contractures in childhood, progressive muscle weakness that starts in a humeroperoneal distribution and later extends to scapular and pelvic girdle muscles, and cardiac involvement that include conduction defects or cardiomyopathy. In this study, we report diagnosis of a patient with Emery–Dreifuss muscular dystrophy type 6 after identification of a novel deletion in FHL1, whose pathogenicity was clarified by RNA sequencing.
What is in the Myopathy Literature?
Authors: Lacomis David , Isfort Michael 
Published: February 2025

Abstract
This update begins with the incidence and features of statin-associated muscle symptoms, which may often be misattributed. Articles on potential muscle mitochondria dysfunction from statins follow, along with recommendations for possibly avoiding statins in some patients with genetic myopathies. Next, autoimmune myopathies, including immune-mediated necrotizing myopathy, myositis with antimitochondrial antibodies, and overlap myositis with lupus, as well as the role of myxovirus protein A identification in muscle specimens, are addressed. The next section includes reports on the significance of elevated serum aldolase with normal creatine kinase and recommended approaches to evaluate a patient with rhabdomyolysis. A cluster of reports on muscle imaging, particularly using ultrasound and magnetic resonance imaging, are covered. They include studies of inherited and inflammatory myopathies and neck extensor myopathy on topics such as imaging features, patterns of involvement, diagnostic utility, and correlation with histopathology. Last, there are discussions on mexiletine versus lamotrigine for nondystrophic myotonias and the treatment of fatty acid oxidation disorders in adults.
The Effect of Prior Use of Statins on the Severity of COVID-19 Disease
Authors: Hasani Hadi , Hamidi Farzaneh , Ahmadi-Forg Fatemeh , Panahi Pardis , Tofighi Khelejan Fatemeh 
Published: February 2025

It has been suggested that the use of statin pills beforehand could potentially influence the outcomes when individuals are hospitalized with COVID-19. In this study, we investigated how the prior use of statin medication could influence the COVID-19 severity parameters. In this retrospective cohort study, we categorized COVID-19 patients into 2 groups: statin users and non-users. Then, various data including age, gender, the patient’s need for ventilation support, the lowest oxygen blood saturation level, the length of hospitalization, receiving remdesivir treatment, and their COVID-19 vaccination status were collected. Out of 168 patients, 62 had taken statin medication before being admitted. Using statins decreased the patient’s need for ventilation support, length of hospitalization, ventilation duration, and oxygen saturation level (P < .001). Interaction effect analysis showed that receiving remdesivir statically affected the length of hospitalization, ventilation duration, and oxygen saturation level but did not significantly affect the association between statins and needing to ventilator. The use of statin pills before COVID-19 admission reduced the requirement for ventilator support.
Comparison of visual interpretation of [I-123] FP-CIT SPECT scans versus reference-based quantitative analysis utilizing a Japanese normal database
Authors: Yamakuni Ryo , Ishii Shiro , Fukushima Kenji , Kakamu Takeyasu , Yusa Masanori , Kikori Katsuyuki , Yamao Tensho , Takahashi Noriyuki , Sekino Hirofumi , Itagaki Shuntaro , Miura Itaru , Ito Hiroshi 
Published: February 2025

Objective
Dopamine transporter single-photon emission computed tomography (DAT-SPECT) plays an important role in diagnosing parkinsonism. Recently, a reference-based quantitative analysis utilizing a Japanese normal database for DAT-SPECT was developed. This study aimed to investigate the frequency and trends of cases wherein the analysis- and physician-based diagnoses diverged.

Methods
Two physicians performed an interpretation task twice on 195 DAT-SPECT scans. After assessing intra- and intertester agreements, disagreements were resolved by consensus. For the reference-based quantitative analysis, the calibrated specific binding ratio (cSBR), calibrated asymmetry index (cAI), and Z-scores were measured. Images were grouped according to physician consensus and the negative–positive difference from thresholds (Z-score of less than −2.0 and/or cAI of more than 12.22) as follows: group 1 (physician, normal; quantitative analysis, normal; n = 70), group 2 (abnormal; normal; n = 4), group 3 (normal; abnormal; n = 31), and group 4 (abnormal; abnormal; n = 90).

Results
Median cSBRs and Z-scores decreased in order from group 1 to group 4. Median cAI values increased in the order of groups 1, 3, 2, and 4. Significant differences were observed between groups 1 and 2 for cSBRs and cAIs; groups 2 and 3 for Z-scores; groups 2 and 4 for cSBRs and Z-scores; and groups 1 and 3, 1 and 4, and 3 and 4 for all parameters (Kruskal–Wallis and Steel–Dwass tests).

Conclusion
In approximately 18% of cases, the visual interpretation of physicians diverged from the reference-based quantitative analysis based on a Japanese normal database. It is crucial to appropriately utilize DAT-SPECT reference-based quantitative analysis as a diagnostic aid.
Contribution of tubarial salivary gland function detected through 68Ga-prostate-specific membrane antigen PET/computed tomography to total salivary gland function
Authors: Kaplan İhsan , Yeprem Ömer , Kömek Halil , Kepenek Ferat , Güzel Yunus , Karaoğlan Hüseyin , Yildirim Mehmet Serdar , Şenses Veysi , Kiliç Ridvan , Kaya İpek Fulya , Budak Emine , Yanarateş Ahmet , Can Canan 
Published: February 2025

Objective
This study aimed to determine the contribution of tubarial salivary glands to total salivary gland function using quantitative parameters obtained from 68Ga-prostate-specific membrane antigen (PSMA) PET/computed tomography (PET/CT), including salivary gland volume (SV) and salivary gland function (SF).

Method
This retrospectively designed study included 102 patients with prostate cancer (PCa) who had undergone 68Ga-PSMA PET/CT for staging purposes between January 2022 and December 2023. Patients with missing data, those with tumors in the head and neck region, those who received radiotherapy to the head and neck region, those who underwent surgery in the head and neck region, those with any salivary gland-related disease, those previously treated with radioactive iodine, and those who received lutetium-177 (177Lu) therapy were excluded from the study.

Results
All 102 patients included in the study were male and diagnosed with PCa. The mean age of the patients was calculated as 72.53 ± 7.58 years. Patients’ tubarial SV% and tubarial SF% values were calculated as 7.76 ± 4.01 and 2.58 ± 1.34, respectively. The percentage volume of tubarial glands was found to be statistically significantly higher than that of sublingual glands (P < 0.001, Wilcoxon signed-rank test). No statistical difference, however, was observed in their contributions to total function (P = 0.506).

Conclusion
When examining the volume ratios of salivary glands showing PSMA expression, it was found that the tubarial salivary glands had a higher volumetric ratio but a lower contribution to total function. We recommend considering these ratios when administering treatments that affect salivary gland functions.
Cytoreductive nephrectomy for oligometastatic clear cell renal cell carcinoma in the era of immuno-oncology
Authors: Marandino Laura , Mollica Veronica , Campi Riccardo ,   the European Association of Urology (EAU) Young Academic Urologists (YAU) Renal Cancer working group
Published: February 2025

Purpose of review
Advancements in immune-oncology treatments and metastasis-directed therapy (MDT) techniques have significantly transformed treatment paradigms for patients with oligometastatic clear cell renal cell carcinoma (ccRCC). Within this evolving therapeutic landscape, the role of cytoreductive nephrectomy remains a topic of debate. This review aims to synthesize recent literature regarding the role of cytoreductive nephrectomy for patients with oligometastatic ccRCC in the contemporary immune-oncology era.

Recent findings
While no prospective data are available regarding the role of cytoreductive nephrectomy for patients with oligometastatic ccRCC in the new immune-oncology (IO) era, results from recent retrospective studies suggest that careful patient selection remains critical. Apart from patients with symptomatic primary tumors, cytoreductive nephrectomy may still play a role in the treatment of oligometastatic patients with favorable clinical features, such as no immediate need for systemic therapy, absence of adverse metastatic sites, or oligometastatic lesions amenable to MDT. Deferred cytoreductive nephrectomy may have a rationale in patients with a deep response to IO at oligometastatic sites. Prognostic biomarkers to assess the biological behavior of oligometastatic disease and identify patients most suitable for cytoreductive nephrectomy are currently lacking. Novel imaging remains under investigation, with its treatment implications in oligometastatic RCC yet to be established.

Summary
Notwithstanding the lack of prospective evidence, cytoreductive nephrectomy may still play a role for selected patients with oligometastatic ccRCC. Future research efforts should aim to identify prognostic tools aiding tailored decision-making in this setting.
Quality Improvement Interventions for Peripheral Intravenous Catheter Nursing Practices
Authors: Cho Sumi , Kim Eun Man 
Published: February 2025

Background:
The use of peripheral intravenous catheters (PIVC) is a crucial nursing practice for ensuring patient safety.

Purpose:
This systematic review assessed quality improvement (QI) articles focused on nursing insertion and management practices related to PIVCs.

Methods:
A comprehensive search was performed. The Quality Improvement Minimum Quality Criteria Set (QI-MQCS) was used to appraise the quality of QI studies by 2 independent reviewers.

Results:
A total of 27 studies were included. More than half of the studies did not meet the sustainability and spread QI-MQCS criteria. QI interventions focused on ultrasound-guided PIVC placement, PIVC dressing products or other catheter devices, and bundles for PIVC practices. The improvements in PIVC-related patient outcomes and nurses’ capabilities were reported.

Conclusion:
Further research is needed to identify detailed QI protocols for ensuring the sustainability and cost-effectiveness of interventions and to facilitate the application of QI in diverse types of hospitals.
Career Trends of University of Minnesota School of Public Health Alumni: Baseline Survey Results for a Longitudinal Study
Authors: Weiss Nicole M. , Leider Jonathon P. , Kaltved Darren , Thao Kablia , Pettigrew Melinda 
Published: February 2025

Objective:
This work describes baseline results of the University of Minnesota (UMN) School of Public Health (SPH) Career Trends Survey (CTS), allowing for comparison to future CTS data.

Design and Setting:
The UMN SPH CTS was fielded using multiple methods, including paper and online, from January to March 2021.

Participants:
All US-based (at time of survey) UMN SPH alumni for whom the school maintained contact information were eligible to complete the survey. In total, 8817 alumni received the survey and 1966 responded (22% response rate).

Main Outcome Measure:
We examined the proportion of graduates’ first jobs by job sector over time, the proportion of graduates who switched job sectors over time, and how closely graduates’ first jobs related to public health over time.

Results:
Graduates overwhelmingly reported that their first jobs were either “somewhat related” or “strongly related” to public health, but a smaller proportion of graduates in the 2010s reported their first jobs being “strongly related” to public health compared to graduates from the first decades for which we have data.

Conclusions:
Data suggest a noteworthy trend: proportionally fewer of our recent public health graduates are going into governmental public health. Though a more nationally representative dataset is still needed, our results are a crucial step forward in determining how to mitigate the staffing up difficulties faced by many public health agencies.
Shifting Connections: Assessing Changes in a Rural Social Network Addressing Adverse Childhood Experiences Over Time
Authors: Lawlor Jennifer A. , Puma Jini , Powers Jamie N. , Martinez Marlayna , Varda Danielle , Leiferman Jenn A. 
Published: February 2025

Context:
The present study was designed in the context of a movement towards using community-scale network-based approaches to address adverse childhood experiences (ACEs). Though these types of networks have become more common, assessments over time following typical network-building activities have been limited.

Objective:
This study focused on the question: To what extent does a rural ACEs network improve exchanges among network members following an intervention focused on improving interactions and networking among members?

Design:
We employed a pre-post design, assessing partnerships among organizations addressing ACEs within a single rural community with a baseline assessment and a follow-up assessment three years later.

Setting:
The study was conducted in the rural San Luis Valley in Colorado. It was part of a larger federally-funded, community-engaged study, entitled Supporting Trauma Awareness and Nurturing Children’s Environments (STANCE).

Participants:
Participants for this study were representatives of organizations in the network (n = 59 in T1 and n = 58 in T2, n = 56 overlapping organizations across time points). Each participant was asked to report about their organization’s partnerships in the network at two time points.

Intervention:
Between the baseline and follow-up assessments, an intervention to further develop the network was implemented. It included hosting a networking event among organizations working on ACEs and the development of a subcommittee of the local interagency oversight group that focused on promoting information-sharing about early childhood and ACEs among local organizations.

Main Outcome Measures:
Outcome measures included: clustering, path length, centrality and centralization, and density over time.

Results:
We identified changes across key network metrics, indicating that the network had increased centrality and centralization over time, decreased average path length, and increased clustering and density across three sub-networks.

Conclusions:
Changes identified in this network provide evidence that ACEs networks can change in response to focused network development activities.
Doravirine associated with greater LDL cholesterol reduction in people with HIV switching antiretroviral regimens
Authors: Bellomo Michele , Gianotti Nicola , Hasson Hamid , Canetti Diana , Nozza Silvia , Guffanti Monica , Messina Emanuela , Spagnuolo Vincenzo , Lolatto Riccardo , Diotallevi Sara , Castagna Antonella , Galli Laura , Muccini Camilla 
Published: February 2025

In this observational cohort study, the objective was to compare low-density lipoprotein (LDL) cholesterol dynamics in people with HIV (PWH) who switched to a regimen containing doravirine (DOR), rilpivirine, dolutegravir, or bictegravir and were naïve to the studied drugs.
Generalized additive mixed models were used to examine LDL cholesterol dynamics.
LDL cholesterol was measured in 2381 PWH: during the first two years, DOR had the greatest lowering effect and showed the most favorable lipid outcome.
Interventions to improve medication adherence in persons with mental disorders
Authors: Kedare Jahnavi , Faye Abhijeet 
Published: February 2025

Purpose of review
Nonadherence to medication is prevalent in patients with mental illness. Various factors responsible for it. As a result, there are more hospitalizations, increased risk of suicide and increased cost of care. Thus, there is a need for effective interventions to improve adherence in mentally ill patients.

Recent findings
Adherence to medication includes participation of patient in decision making. Interventions in the recent years help patients through techniques like psychoeducation, motivational interviewing and cognitive behaviour therapy. Interventions involve both patients and caregivers. There is a growing body of research about use of technology -based interventions using smart phones, various applications, digital platforms and artificial intelligence. Recent findings of research indicate that a combination of methods of intervention may be more useful in improving adherence. Some conventional interventions yield good results. Robust research is needed in the field of technology- based interventions.

Summary
Non adherence to medication leads to poorer health outcomes and hampers integration of the patient in the society. A collaborative effort of the team of healthcare providers, the patient and caregivers is the way ahead for better adherence and good quality of life.
Global prevalence of internet addiction among university students: a systematic review and meta-analysis
Authors: Liu Xin , Gui Zhen , Chen Zi-Mu , Feng Yuan , Wu Xiao-dan , Su Zhaohui , Cheung Teris , Ungvari Gabor S. , Liu Xuan-Chen , Yan Yi-Ran , Ng Chee H. , Xiang Yu-Tao 
Published: February 2025

Purpose of review
The prevalence of internet addiction among university students has been extensively studied worldwide, however, the findings have been mixed. This meta-analysis aimed to examine the global prevalence of internet addiction in university students and identify its potential moderators.

Recent findings
A total of 101 eligible studies, comprising 128,020 participants across 38 countries and territories, were included. The pooled global prevalence of internet addiction among university students was 41.84% [95% confidence interval (95% CI): 35.89–48.02]. Significant differences in the prevalence were observed across different income levels, regions, periods of COVID-19 pandemic, and cut-off values of the Internet Addiction Test (IAT). Sample size was negatively associated with internet addiction prevalence, while depression prevalence was positively associated with internet addiction prevalence. Male students had a significantly higher risk of internet addiction compared to female students [pooled odd ratio (OR): 1.32, 95% CI: 1.19–1.46].

Summary
This meta-analysis found that the prevalence of internet addiction was high among university students, which had increased since the COVID-19 pandemic. Screening and intervention measures to address internet addiction should prioritize students with an increased risk including male students, those from lowerincome regions and those with depression.
Drug addiction and impact of urbanization: a systematic review
Authors: Lin Kelly , Jia Jie , Zhu Xiaoyu , Zhang Bei , Zhu Zhaohua , Li Li , Sun Jing 
Published: February 2025

Purpose of review
Using the ecological public health framework, this study aims to systematically review the risk of illicit drug use and its associated negative health outcomes relating to urbanization.

Recent findings
Previous studies have indicated that urbanization associated with increased population density drives segregation of vulnerable communities of low socioeconomic status (SES). Marginalized individuals in segregated communities have increased risk of poor mental health and illicit drug use.

Summary
The results indicated that urban-specific environmental risk factors, individual characteristics and level of social support all influenced risk of drug use, substance use disorder (SUD), overdose, and drug-use associated death. Urban environmental risk factors of economic disparity, marginalization and barriers in accessing healthcare and negative individual characteristics of low education, low income and comorbid diagnosis of mental illness significantly increased risk of drug use. In contrast, better social support reduced the risk of drug use.