bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein kinase CK2: An emerging regulator of cellular metabolism
Authors: Deng Huilin , Rao Xinrui , Zhang Sijia , Chen Leichong , Zong Yan , Zhou Rui , Meng Rui , Dong Xiaorong , Wu Gang , Li Qianwen 
Published: December 2023

AbstractThe protein kinase casein kinase 2 (CK2) exerts its influence on the metabolism of three major cellular substances by phosphorylating essential protein molecules involved in various cellular metabolic pathways. These substances include hormones, especially insulin, rate‐limiting enzymes, transcription factors of key genes, and cytokines. This regulatory role of CK2 is closely tied to important cellular processes such as cell proliferation and apoptosis. Additionally, tumor cells undergo metabolic reprogramming characterized by aerobic glycolysis, accelerated lipid β‐oxidation, and abnormally active glutamine metabolism. In this context, CK2, which is overexpressed in various tumors, also plays a pivotal role. Hence, this review aims to summarize the regulatory mechanisms of CK2 in diverse metabolic pathways and tumor development, providing novel insights for the diagnosis, treatment, and prognosis of metabolism‐related diseases and cancers.
Complex lymphatic anomalies: Challenging diagnostic considerations
Authors: Kothandaraman Venkatraman , Wisener John , Helgerson Paul W. 
Published: December 2023

Key Clinical MessageDiagnosis of complex lymphatic anomalies can be difficult, and biopsies can be associated with significant morbidity. Mediastinal masses with features such as osseous involvement warrant thorough noninvasive evaluation prior to biopsy.
Evaluation of vascular graft infection following Bentall surgery using 18F‐FDG PET/CT scan: A pediatric case report
Authors: Alavi Mehrosadat , Abdinejad Maryam , Rezaei Mehdi , Moaref Alireza 
Published: December 2023

Key Clinical MessageAfter a Bentall surgery, there is a small chance of developing a serious complication called vascular graft infection. 18F‐FDG PET/CT, a new and accurate diagnostic tool, can help detect it early, especially if the symptoms are unusual.AbstractA 14‐year‐old boy who had undergone Bentall surgery 1 year prior presented with symptoms of fever, chills, loss of appetite, and weight loss over the course of a month. The initial Bentall surgery was performed due to an aneurysm of the thoracic aorta, along with severe aortic valve insufficiency and moderate aortic valve stenosis. The patient was referred to the PET/CT department for evaluation of possible endarteritis or infection of Dacron graft, which had been reported in trans‐esophageal echocardiography as suspicious findings. Despite normal blood tests, blood cultures, and other imaging modalities, the 18F‐FDG PET/CT confirmed the diagnosis of vascular graft infection. This diagnostic tool allowed for timely and appropriate treatment and prevention of possible complications.
Photoelectrocatalytic Utilization of CO2: A Big Show of Si‐based Photoelectrodes
Authors: Yu Jiacheng , Hao Xue , Mu Lixuan , Shi Wensheng , She Guangwei 
Published: December 2023

AbstractCO2 is a greenhouse gas that contributes to environmental deterioration; however, it can also be utilized as an abundant C1 resource for the production of valuable chemicals. Solar‐driven photoelectrocatalytic (PEC) CO2 utilization represents an advanced technology for the resourcing of CO2. The key to achieving PEC CO2 utilization lies in high‐performance semiconductor photoelectrodes. Si‐based photoelectrodes have attracted increasing attention in the field of PEC CO2 utilization due to their suitable band gap (1.1 eV), high carrier mobility, low cost, and abundance on Earth. There are two pathways to PEC CO2 utilization using Si‐based photoelectrodes: direct reduction of CO2 into small molecule fuels and chemicals, and fixation of CO2 with organic substrates to generate high‐value chemicals. The efficiency and product selectivity of PEC CO2 utilization depends on the structures of the photoelectrodes as well as the composition, morphology, and size of the catalysts. In recent years, significant and influential progress has been made in utilizing Si‐based photoelectrodes for PEC CO2 utilization. This review summarizes the latest research achievements in Si‐based PEC CO2 utilization, with a particular emphasis on the mechanistic understanding of CO2 reduction and fixation, which will inspire future developments in this field.
Optimizing chitosan‐enriched salicylic acid coating to extend the shelf‐life of fresh‐cut radishes using response surface methodology
Authors: Lv Ruoning , Zuo Changzhou , Tu Kang , Pan Leiqing , Liu Liwang , Peng Jing 
Published: December 2023

AbstractChitosan coating and salicylic acid are two widely used preserving methods for fruits and vegetables in postharvest storage, but very limited research can be found on the application of chitosan‐enriched salicylic acid (CS–SA) coating for fresh‐cut radishes. In this study, three variables (chitosan, salicylic acid, and immersion time) and two responses (whiteness and total bacterial count) were employed to optimize CS–SA process for fresh‐cut radishes using response surface methodology. The results showed that the optimal coating process for fresh‐cut radishes was 1.0% chitosan and 1.0 mM salicylic acid for 1.8 min. The effects of the optimal CS–SA process on the major storage quality and shelf‐life of fresh‐cut radishes were also investigated. Results indicated that CS–SA effectively delayed the decrease of whiteness, firmness, ascorbic acid, and total phenolic content in fresh‐cut radishes during storage. Meanwhile, CS–SA significantly inhibited the microbial growth and extended the shelf‐life of fresh‐cut radishes up to 12 days, much longer than those of non‐ or NaClO‐treated ones with 6 and 8 days, respectively. This study suggests that CS–SA is an efficient alternative for the preservation of fresh‐cut radish products, and the underlying regulation mechanism of CS–SA on delaying browning and microbial growth is worth further exploration.
Biomass‐based lateral root morphological parameter models for rapeseed (Brassica napus L.)
Authors: Zhang Wei‐xin , Wu Qian , Sun Chuan‐liang , Ge Dao‐kuo , Cao Jing , Liang Wan‐jie , Yin Ying‐jun , Li Hong , Cao Hong‐xin , Zhang Wen‐yu , Li Bai‐ming , Xin Yu‐kai 
Published: December 2023

AbstractLateral roots, including adventitious roots, are the main component of rapeseed roots with support, absorb, and synthesis functions and their morphological parameters directly affecting the plant's aboveground growth and yield. Root biomass, as a material base for lateral root growth, can be used as a link between plant phenotypes and their physiological processes, as well as to enhance root 3D growth model mechanisms and accuracy. To quantify the relationships between lateral root morphological indices and the corresponding organ biomass for rapeseed, we used two cultivars, NY 22 (conventional) and NZ 1818 (hybrid), and conducted cultivar and fertilizing cylindrical tube experiments during the 2016–2019, with two fertilizer levels, no fertilizer, and 180 kg N ha−1 fertilizer. The lateral root biomass and morphological parameters were determined during the whole growth period. The biomass‐based lateral root morphological parameter models were developed by analyzing the quantitative relationship between the lateral root morphological indices and their corresponding biomass, and the descriptive models were verified with independent experimental data. The results showed that the correlation (r) of simulated and observed values for the lateral root morphological parameters are all greater than 0.9 with significant levels at p < 0.001. The absolute values of the average absolute difference (da) of simulated and observed values for the lateral root length (LLR), lateral root average diameter (ADLR), lateral root surface area (SALR), and lateral root volume (VLR) are −30.408 cm, −0.003 mm, 12.902 cm2, and 0.039 cm3, respectively. The RMSE values are 175.183 cm, 0.010 mm, 59.710 cm2, and 1.513 cm3, respectively. The ratio of da to the average observed values (dap) for the LLR and VLR are all less than 5%, and the ADLR and SALR are all <6%. The models developed in this paper have good performance and reliability for predicting lateral root morphological parameters of rapeseed. The study provides a mechanistic method for linking the rapeseed growth model with the morphological model using corresponding organic biomass and laying a good foundation for establishing a 3D morphological model for rapeseed root system based on biomass.
Tissue distribution and pharmacokinetics of isoxanthohumol from hops in rodents
Authors: Mukai Rie , Hata Natsumi 
Published: December 2023

AbstractVegetables and fruits contain prenylflavonoids with biological functions that might improve human health. The prenylflavonoid isoxanthohumol (IXA) and its derivative, 8‐prenylnaringenin (8‐PN), have beneficial activities, including anti‐cancer effects and suppression of insulin resistance. However, their pharmacokinetic profile is unclear. Previous studies suggested flavonoids have low systemic availability and are excreted via the feces. Therefore, this study investigated the tissue distribution dynamics of high‐purity IXA (>90%) from hops administered orally, either singly (50 mg/kg body weight [BW]) or daily for 14 days (30 mg/kg BW), to mice. High‐pressure liquid chromatography demonstrated that IXA was absorbed rapidly after a single administration and reached plasma maximum concentration (Cmax) (3.95 ± 0.81 μmol/L) by 0.5 h. IXA was present at high levels in the liver compared with the kidney, pancreas, lung, skeletal muscle, spleen, thymus, and heart. The highest IXA level after 14 days of IXA ingestion was observed in the liver, followed by the kidney, thymus, spleen, lung, and brain. There was no significant difference in IXA accumulation in tissues between the single and multiple dose groups. Analyses of the livers of rats treated with different concentrations of IXA (112.5–1500 mg/kg BW) once a day for 28 days demonstrated that IXA accumulated dose‐dependently with a correlation coefficient of .813. The accumulation of 8‐PN was dependent on the intake period but not the intake amount of IXA (correlation coefficient −.255). In summary, IXA and 8‐PN were detected in tissues and organs up to 24 h after ingestion, suggesting that orally ingested IXA might have health benefits as a nutraceutical.
Changes in food quality and characterization under thermal accumulation conditions during Chinese cooking
Authors: Zhang Mingzan , Yang Yun , Zhang Hongwen , Li Cuiqin , He Laping , Deng Li 
Published: December 2023

AbstractChinese cooking is the primary treatment method for table food in China. The process is complex and large‐scale, which is important to the macroeconomy and national nutrition and health. First, this article puts forward the concept of thermal accumulation for Chinese cooking by taking pork tenderloin fried at different oil temperatures, explaining changes in moisture content, hardness, and color with different thermal accumulation conditions, and measuring kinetic parameters. The variations of L* and b* obtained by the experimental results belong to the first‐order reaction kinetic model, while the changes in water content and shear force belong to the zero‐order reaction kinetic model. Simultaneously, the superheat value is used as a thermal accumulation indicator, combined with sensory evaluation to determine that the Z value of the human sensory overheating of pork tenderloin is 99°C, and Os,max (Z = 99°C, the reference temperature is 110°C) is 5.86 min.
Laser constructed bulk oxygen vacancy caused high P doping for boosting the sodium‐storage capability
Authors: Li Zhimeng , Huang Man , Chang Bin , Ge Jinyu , Xin Di , Jiang Di , Liu Hong , Zhou Weijia 
Published: December 2023

AbstractDefect‐assisted heteroatom doping can effectively enhance the intrinsic transfer characteristics of carriers in the crystal structure, which advantages over fast and efficient charge storage. In this work, a three‐dimensional self‐supporting titanium dioxide nanoparticle rich in bulk vacancies (L‐TiOx) on titanium substrate is synthesized by pulsed laser. Different from the surface vacancies, the bulk oxygen defects of L‐TiOx cause a uniform and bulk phosphorus (P) doping with a high concentration of ~5.71 at %, which endows the elevated electronic conductivity, and accelerates the transport of Na+. The obtained P‐doped L‐TiOx (LP‐TiOx) as an anode material in sodium‐ion batteries (SIBs) provides a reversible capacity of 400 mAh g−1 at 200 mA g−1, outstanding rate capability of 196 mAh g−1 at 10,000 mA g−1, and maintains stable performance over 1000 cycles. In situ X‐ray diffraction and ex situ high‐resolution transmission electron microscopy show that LP‐TiOx exhibits robust mechanical behavior with almost no lattice change under (de)sodiation. This work supplies a novel idea for high‐concentration bulk heteroatoms doping to enhance the electrochemical performance of SIBs.
AFIS Report on Challenges for the Near Future
Authors: Alix Christophe , Garnier Jean‐Luc , Le Mouëllic Mikael , Alt Laurent , Vingerhoed Rob , Bouyaud Mickaël 
Published: December 2023

ABSTRACTSystems engineering shall adapt itself with the changes of the world. System engineering communities like (AFIS 2022) and (INCOSE 2021) have been developing their visions with the identification of needs that systems engineering shall integrate to address new challenges. The systems engineering discipline shall be now considered at the enterprise level and be included in the governance of the project. Systems engineering and system thinking shall be deployed on all layers of the organization and horizontally to ensure the consistency the definition, production, and all phases of the lifecycle of the system within all involved organizations. The future is paved with unknowns. Systems engineering can integrate new methodologies, new posture to complete its analytical based tools to better face new kinds of complexity. These new challenges are often due to the reallocation of functions and responsibilities between human and machine in the context of autonomous systems. These collaborative socio‐technical systems induce new questions for systems engineering which needs to integrate new domain of skills and interacts with new disciplines from the soft sciences.
Understanding the Indirect Effects of Interactive Systems Within Systems of Systems
Authors: Bornes Laetitia , Letondal Catherine , Vingerhoeds Rob 
Published: December 2023

ABSTRACTUntil recently, research into the sustainable design of interactive systems has primarily focused on the direct material impact of a system, through improving its energy efficiency and optimizing its lifecycle. Yet the way a system is designed and marketed often has wider repercussions, such as rebound effects, and systemic change in practices. These effects are harder to assess (and to anticipate) than the direct physical impact of the construction and use of the system itself. Current tools are unable to account for the complexity of these effects: the underlying causal mechanisms, their multi‐level nature, their different temporalities, and the variety of their consequences (environmental and societal). This is why we are seeking to develop a specific methodology and tool, inspired by systemic design and system dynamics. These are intended for decision‐makers and designers of interactive systems within systems of systems (for example, in the fields of agricultural robotics or public transportation). In this paper, we present this modeling approach and our prototype tool through the example of a second‐hand clothing sales platform.
WONKA: An Ontology‐Aided Model‐Based Systems Engineering Analysis for Early V&V on Heterogeneous Systems and Applications
Authors: Delabeye Romain , Penas Olivia , Plateaux Régis 
Published: December 2023

ABSTRACTThis research is undertaken as part of the EU‐funded EnerMan project aiming at improving the energy sustainability of manufacturing systems. In such a large project, with 22 partners over 10 countries, a first challenge addresses the collaborative design of an energy management system (EnMS) for the improvement of energy sustainability, while offering the flexibility and agility necessary for the diversity of the industrial cases studied and the partners involved. In a second stage, industrial use cases are generally too constrained to easily proceed to the verification and validation (V&V) of the scientific approaches tackling their challenges. In this context, our research contributions consist of methodologies and automated approaches to: (i) ensure the consistent collaborative integrability of developments, in a sustainable manufacturing context, and (ii) perform the verification and validation of such contributions on multiple systems, assessing their scalability on heterogeneous systems, environments, and missions in a V&V context.
Purification, identification and molecular docking of dual‐functional peptides derived from corn protein hydrolysates with antioxidant and antiadhesive activity against Helicobacter pylori
Authors: Li Guanlong , Liu Xiaolan , Miao Zhengfei , Fu Jinshuang , Zheng Xiqun 
Published: December 2023

AbstractBACKGROUNDMore than 50% of the world's population is infected with Helicobacter pylori, which is classified as a group I carcinogen by the World Health Organization (WHO).RESULTSCorn protein dual‐functional peptides were identified and functionally analyzed in vitro and in silico. Two novel dual‐functional peptides were identified as Cys‐Gln‐Asp‐Val‐Pro‐Leu‐Leu (CQDVPLL, CQ7) and Thr‐Ile‐Phe‐Pro‐Gln‐Cys (TIFPQC, TI6) using nanoscale liquid chromatography coupled to tandem mass spectrometry (nano‐LC–MS/MS). The antiadhesive effects against H. pylori of CQ7 and TI6 were 45.17 ± 2.41% and 48.62 ± 1.84% at 4 mg mL−1, respectively. In silico prediction showed that CQ7 and TI6 had good physicochemical properties. Molecular docking demonstrated that CQ7 and TI6 could bind to the adhesins BabA and SabA by hydrophobic interactions and hydrogen bonds, preventing H. pylori infection. Moreover, CQ7 showed strong antioxidant activity due to its unique amino acid composition.CONCLUSIONThe present study demonstrated that the identified peptides, CQ7 and TI6, possess antioxidant and antiadhesive effects, preventing H. pylori infection and alleviating oxidative injury to the gastric mucosa. © 2023 Society of Chemical Industry.
Ultrasound Combined With Continuous Microbubble Injection to Enhance Catheter‐Directed Thrombolysis in Vitro and in Vivo
Authors: Feng Shuang , Wang Shan , Tang Jiawei , Zhu Xiansheng 
Published: December 2023

ObjectivesTo investigate the influence of microbubble perfusion mode on catheter‐directed thrombolysis (CDT), we evaluated the effect of two different types of microbubble perfusion modes (continuous injection versus bolus injection) on the thrombolytic efficacy of CDT in vitro and further assessed the effect of continuous microbubble injection on CDT in vivo.MethodsIn an in vitro experimental setup, 50 fresh bovine whole blood clots were randomized into five groups: ultrasound and continuous microbubble injection‐enhanced CDT (US + cMB + CDT), ultrasound and bolus microbubble injection‐enhanced CDT (US + bMB + CDT), US + CDT, US + cMB, and CDT. In a porcine femoral vein thrombosis model, 16 completely obstructive thrombi were randomly assigned to the CDT group and the US + cMB + CDT group, respectively. Thrombolysis rate, vascular recanalization rate, hematoxylin–eosin, and immunofluorescence staining were used to evaluate the thrombolytic effect in vitro and in vivo.ResultsIn vitro, US + cMB + CDT group resulted in a significantly higher thrombolysis rate compared with the other four groups (P < .05). Meanwhile, this group also demonstrated a looser clot structure and more disrupted fibrin structures. In vivo, US + cMB + CDT contributed to a significantly higher vascular recanalization rate compared with CDT (87.50% versus 25.00%, P < .05).ConclusionsUS + cMB + CDT was more effective than US + bMB + CDT in thrombolysis, and ultrasound combined with continuous microbubble injection could enhance the thrombolytic efficacy of CDT.
A broadband mono‐cone antenna employing a shorted parasitic ring and parasitic metal pillars
Authors: Zhang Xiao Hong , Yu Weiliang , Luo Guo Qing 
Published: December 2023

AbstractThis letter proposes a broadband mono‐cone antenna with a shorted parasitic ring and parasitic metal pillars. Four parasitic metal pillars expand the high‐frequency operation band, while a shorted parasitic ring increases the current flow path and expands the low‐frequency operation band. A 148.3% impedance bandwidth for VSWR ≤ 2 from 0.831 to 5.6 GHz is attained. The antenna has stable radiation performance across the entire operation spectrum. The simulated and measured results show a good agreement. It is exceptionally compatible with GSM900, DCS1800, PCS1900, UMTS, IMT2000, WiBro, WiMAX2350/3500, LPWAN, wireless LAN (IEEE 802.11b), and a portion of the WLAN/Wi‐Fi frequency spectrum. Indoor applications such as wireless energy collection, partial discharge detection, and so on are possible for the proposed antenna.
Technical note: Commissioning of a linear accelerator producing ultra‐high dose rate electrons
Authors: Cetnar Ashley J. , Jain Sagarika , Gupta Nilendu , Chakravarti Arnab 
Published: December 2023

AbstractBackgroundUltra‐high dose rate radiation (UHDR) is being explored by researchers in promise of advancing radiation therapy treatments.PurposeThis work presents the commissioning of Varian's Flash Extension for research (FLEX) conversion of a Clinac to deliver UHDR electrons.MethodsA Varian Clinac iX with the FLEX conversion was commissioned for non‐clinical research use with 16 MeV UHDR (16H) energy. This involved addition of new hardware, optimizing the electron gun voltages, radiofrequency (RF) power, and steering coils in order to maximize the accelerated electron beam current, sending the beam through custom scattering foils to produce the UHDR with 16H beam. Profiles and percent depth dose (PDD) measurements for 16H were obtained using radiochromic film in a custom vertical film holder and were compared to 16 MeV conventional electrons (16C). Dose rate and dose per pulse (DPP) were calculated from measured dose in film. Linearity and stability were assessed using an Advanced Markus ionization chamber.ResultsEnergies for 16H and 16C had similar beam quality based on PDD measurements. Measurements at the head of the machine (61.3 cm SSD) with jaws set to 10×10 cm2 showed the FWHM of the profile as 7.2 cm, with 3.4 Gy as the maximum DPP and instantaneous dose rate of 8.1E5 Gy/s. Measurements at 100 cm SSD with 10 cm standard cone showed the full width at half max (FWHM) of the profile as 10.5 cm, 1.08 Gy as the maximum DPP and instantaneous dose rate of 2.E5 Gy/s. Machine output with number of pulses was linear (R = 1) from 1 to 99 delivered pulses. Output stability was measured within ±1% within the same session and within ±2% for daily variations.ConclusionsThe FLEX conversion of the Clinac is able to generate UHDR electron beams which are reproducible with beam properties similar to clinically used electrons at 16 MeV. Having a platform which can quickly transition between UHDR and conventional modes (<1 min) can be advantageous for future research applications.