bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of family socioeconomic status on adolescent mental and physical health: the mediating role of parental involvement in youth sports
Authors: Yang Wenli , Xiang Zubing , Hu Hong , Zheng Haoyuan , Zhao Xin 
Published: February 2025

IntroductionThe physical and mental health of adolescents is a crucial cornerstone for social development. Therefore, this study aimed to examine whether family socioeconomic status made a difference in Chinese teenage mental and physical health and to disentangle the mediating role of parental involvement in youth sports in the process in which family socioeconomic status influenced adolescent health.MethodsA quantitative analysis used a sample of approximately 11,000 adolescents from Chinese middle schools. The research employed structural equation modelling (SEM) to explore the relationships among family socioeconomic status, parental involvement in youth sports, and adolescent mental and physical health.ResultsThe findings indicated that both family socioeconomic status and parental involvement in youth sports significantly positively predict levels of adolescents’ physical health and mental health. Further analysis revealed that parental involvement in youth sports mediated the relationship between family socioeconomic status and adolescent health.DiscussionIt is evident that parental involvement in youth sports plays a crucial role in adolescent mental and physical health. Regardless of family socioeconomic status, parents should actively engage in sports activities with their children, which is not only an important way to promote adolescents’ health but also a manifestation of realizing health equity.
Tooth loss trajectories and their association with all-cause mortality among older Chinese adults
Authors: Zhang Xiaoming , Zeng Rui , Ye Dongmei , Shi Mengxia , Zhu Aizhang , Chen Lihuan , Fan Tenghui , Zhu Ke , Xie Fayi , Zhu Wan , Zeng Yufei , Wang Jiang , Zhang Wenwu 
Published: February 2025

BackgroundThe association between tooth loss trajectories and all-cause mortality has not been sufficiently explored. This study aims to examine the relationship between tooth loss trajectories and all-cause mortality in Chinese adults aged 65 years and older.MethodsThis study included 3,726 participants from the Chinese Longitudinal Healthy Longevity Study (CLHLS). The inclusion criteria required participants to be aged 65 years or older, with complete data on tooth count at baseline and at least one follow-up survey. Participants were excluded if they had missing data on death, time to death, or if their they reported tooth count showed an abnormally high increase. The mean age of participants was 85.16 ± 10.7 years. To identify distinct trajectories of tooth loss, growth mixture models (GMM) were employed. Cox regression analysis was utilized to assess the association between tooth loss trajectories and all-cause mortality. Sensitivity analyses were conducted to test the robustness of the findings, while subgroup analyses were performed to explored potential variations in association across different demographic groups.ResultsThe prevalence of edentulism at baseline was 37.13%, with a cumulative incidence of 15.8% over 10-year period. Three distinct tooth loss trajectories were identified during follow-up of 9.41 years: (1) progressively mild loss: comprising 312 participants (8.37%); (2) progressively severe loss, comprising 505 participants (13.55%); and (3) edentulism group, comprising 2,909 participants (78.07%). The median follow-up times for each group were 5.91 years, 3.44 years, and 1.84 years, respectively. During the follow-up period, the number of deaths were 114 (36.54%) in the progressively mild loss group, 274 (54.26%) in the progressively severe loss group, and 2,284 (78.51%) in the edentulism group. Compared to the progressively mild loss group, the hazard ratio (HR) for all-cause mortality was 1.29 (95% CI, 1.01–1.64) in the progressively severe loss group, and 1.60 (95% CI, 1.28–1.99) in the edentulism group.ConclusionsThis study identified three distinct tooth loss trajectories among older Chinese adults, with the edentulism group exhibiting the strongest association with all-cause mortality. These findings highlight the crucial importance of maintaining oral health and preserving natural teeth to promote longevity and improve overall health outcomes in older adults.
Understanding greenspace attachment across the life-course: the role of personal history in establishing spatial meaning amongst older people in the Netherlands
Authors: Lauwerijssen Rachel , Mell Ian , Barker Adam 
Published: February 2025

IntroductionGreenspaces facilitate bonds between people and place and may hold meaning in improving health and wellbeing. Studies indicate that contact with nature can promote health, but the evidence relies on cross-sectional study designs and lacks studies incorporating a life-course perspective. Understanding greenspace attachment across a lifetime may hold meaning in improving lifelong health and wellbeing. It remains unclear how and why people, independent of their life-stage, develop and maintain an attachment to greenspace.MethodsThis exploratory study explores the role of personal experiences and memories in developing and nurturing greenspace attachment across a lifetime, focusing on older adults’ personal histories. Semi-structured, oral history focused interviews (n = 20) were conducted in 2019 with residents living in Breda and Tilburg (the Netherlands).ResultsThe findings suggest that significant personal experiences helped participants to form attachments to various types of greenspaces regardless of their life stage and greenspace typology. The childhood life phase is a crucial phase for participants to develop greenspace attachment and their attachment varies through their lifetime. Everyday greenery is perceived as an essential part to their local environment and assists in maintaining attachments and restoration.DiscussionUnderstanding the creation and fostering of greenspace attachment can inform urban planning initiatives, streetscape design, and greenspace management to prioritise the design and planning of multifunctional, intergenerational, and inclusive greenspaces that cater to the needs, interests, and values for people across all age groups.
Match-play data according to playing categories in badminton: a systematic review
Authors: Winata Bagus , Brochhagen Joana , Apriantono Tommy , Hoppe Matthias Wilhelm 
Published: February 2025

IntroductionThis systematic review aimed to investigate differences in match-play data according to the five playing categories in badminton.Materials and methodsThe systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searches were conducted on ScienceDirect, PubMed, Google Scholar, Scopus, Web of Science, and Cochrane Library databases. Studies assessing technical-tactical actions, activity profiles, or external and internal loads as match-play outcome measures according to the five playing categories in badminton were deemed eligible. Quality assessment was performed using a modified version of the AMSTAR-2 checklist to compare the outcome measures, effect sizes (ES) and associated 95% confidence intervals were calculated.ResultsOf the 12,967 studies that were identified, 34 met the eligibility criteria. Among these, 29 and five were rated as excellent and good quality, respectively. Some individual ESs of activity profiles showed up to large differences (ES ≤ 4.52) favouring the men's compared with the women's singles category. Some individual ESs of activity profiles showed up to large differences (ES ≤ -2.72) favouring the women's doubles category compared with other doubles categories. The overall ESs for the activity profiles were large (ES = −0.76 to −0.90), favouring the doubles over the singles categories in both sexes.DiscussionThere are up to large differences in match-play data according to the five playing categories in badminton, each category placing specific demands on the players. Thus, each category requires specific training and testing procedures, what should be considered by scientists and coaches.
Comprehensive overview of the toxicities of small-molecule cryoprotectants for carnivorous spermatozoa: foundation for computational cryobiotechnology
Authors: Karimi Isaac , Mohammad Layth Jasim , Suvitha A. , Haidari Zohreh , Schiöth Helgi B. 
Published: February 2025

BackgroundThe specific and non-specific toxicities of cryoprotective agents (CPAs) for semen or spermatozoa cryopreservation/vitrification (SC/SV) remain challenges to the success of assisted reproductive technologies.ObjectiveWe searched for and integrated the physicochemical and toxicological characteristics of small-molecule CPAs as well as curated the information of all extenders reported for carnivores to provide a foundation for new research avenues and computational cryobiology.MethodsThe PubMed database was systematically searched for CPAs reported in SC/SV of carnivores from 1964 to 2024. The physicochemical features, ADMET parameters, toxicity classes, optimized structures, biological activities, thermodynamic equilibrium constants, and kinetic parameters were curated and assessed computationally.ResultsSixty-two relevant papers pertaining to CPAs used in SC/SV were found, and 11 CPAs were selected. Among the properties of CPAs, the molecular weight range (59–758 g/mol), melting point (−60°C to 236°C), XlogP3 (−4.5 to 12.9), topological polar surface area (TPSA; 20–160 Å2), Caco2 permeability (−0.62 to 1.55 log(Papp) in 10–6 cm/s), volume of distribution (−1.04 to 0.19 log L/kg), unbound fraction of a CPA in plasma (0.198–0.895), and Tetrahymena pyriformis toxicity (log µg/L; −2.230 to 0.285) are reported here. Glutathione, dimethyl formamide, methyl formamide, and dimethyl sulfoxide were used as the P-glycoprotein substrates. Ethylene glycol, dimethyl sulfoxide, dimethyl formamide, methyl formamide, glycerol, and soybean lecithin showed Caco2 permeabilities in this order, whereas fructose, glutathione, glutamine, glucose, and citric acid were not Caco2-permeable. The CPAs were distributed in various compartments and could alter the physiological properties of both seminal plasma and spermatozoa. Low volume distributions of all CPAs except glucose indicate high water solubility or high protein binding because higher amounts of the CPAs remain in the seminal plasma.ConclusionADMET information of the CPAs and extenders in the bipartite compartments of seminal plasma and intracellular spaces of spermatozoa are very important for systematic definition and integration because the nature of the extenders and seminal plasma could alter the physiology of cryopreserved spermatozoa.
Incidence of hypernatremia in dogs treated with single dose activated charcoal for acute toxicant ingestion: multi-center retrospective study (2018–2023)
Authors: Young Timothy , Walton Rebecca A. L. , Cheng Poyee , Cai Jiazhang , Mochel Jonathan P. , Peterson Katherine 
Published: February 2025

ObjectiveTo retrospectively evaluate the incidence and clinical significance of hypernatremia in dogs administered a single dose of activated charcoal (AC) or activated charcoal with sorbitol (ACS) for acute toxicant ingestion.MethodsRetrospective study between the years 2018–2023. Ninety-six dogs evaluated by a university teaching hospital and private practice emergency hospital treated for acute toxicant ingestion with a single dose of activated charcoal, with or without sorbitol.ResultsMedical records were retrospectively reviewed. No dog developed hypernatremia, defined as sodium &gt;155 mEq/L, during the study period. The toxicant ingested was not significantly associated with a change in sodium (Na) at any time point (P = 0.433 at 6–12 h, P = 0.09 at 12–14 h, and P = 0.486 at 24–48 h). Ingestion of multiple toxicants, compared to single toxicant ingestion, was also not significantly associated with a change in Na at any time point (P = 0.126 at P = 6–12 h, P = 0.452 at 12–24 h, and P = 0.516 at 24–48 h). Time from ingestion to presentation was not significantly associated with a change in Na at any time point (P = 0.422 at 6–12 h, P = 0.881 at 12–24 h, and P = 0.516 at 24–48 h). The administration of AC compared to ACS was not significantly associated with a change in Na at any time period (P = 0.715 at 6–12 h, P = 0.137 at 12–24 h, P = 0.582 at 24–48 h). There was a significant difference between Na on presentation and at 12–24 h and 24–48 h (P = 0.025 and P = 0.015, respectively.) Median Na values decreased at all-time points when compared to presentation, −0.90 at 6–12 h (standard deviation (SD) 2.74), −1.38 at 12–24 h (SD 4.81) and −2.11 at 24–48 h (SD 5.34).ConclusionsThis study demonstrated a statistically significant, but unlikely clinically significant, decrease in Na in dogs who received single dose AC or ACS for acute toxicant ingestion.
The Effect of a Magnetic Field on the Enzymatic Activities of Common Airborne Aspergillus Strains Isolated from Indoor Environments
Authors: Anaya-Villalpanda Matilde , Gámez-Espinosa Erasmo , Borrego-Alonso Sofía 
Published: February 2025

The aim of this study was to evaluate the effect of an extremely low-frequency oscillating magnetic field on the enzymatic activities of common airborne Aspergillus sp. strains that were isolated from indoor environments. A D-optimal experimental design with three factors was applied: magnetic field density (0.5 to 2 mT), exposure time (0.5 to 2 h), and Aspergillus sp. strains (A. ellipticus, A. japonicus, A. flavus, and A. fumigatus). The response variables were exoenzymatic indexes (cellulolytic, amylolytic, proteolytic, lipolytic, and hemolytic) and pH, as a measure of organic acid production. A. ellipticus was the highest producer of organic acids, and A. japonicus was as pathogenic as A. fumigatus. Different magnetobiological effects were observed: on enzyme secretion in the remaining strains, we detected no appreciable effect (Ilip and Iprot of A. flavus), inhibition (Ilip of A. ellipticus; Icel and Iamil of A. japonicus; Iamil and Iprot of A. fumigatus), and stimulation. Predictive quadratic models were obtained, and 2 mT for 2 h was the magnetic treatment regime that influenced the fungal enzymatic activity. These physiological changes following magnetobiological effects could be influenced during fungal sporulation and must thus be considered in aeromicrobiology studies. They can also be beneficial for obtaining industrial-use enzymes, but detrimental to the biodeterioration of different materials and human health.
Гарантії захисту трудових прав викривачів: міжнародний досвід та актуальна національна судова практика
Authors: Кайда Н. Я. , Дубас Д. І. 
Published: February 2025

У статті досліджено гарантії захисту трудових прав викривачів у контексті боротьби з корупцією. Звернута увага, що гарантії захисту трудових прав викривачів є ключовим інструментом у боротьбі з корупцією. Виявлені основні в Україні проблеми в їх реалізація, зокрема є прогалини у законодавстві, нечіткість визначень термінів, складність процедур, відсутність ефективних механізмів захисту та недостатня обізнаність працівників і роботодавців. Вказано, що ці недоліки створюють бар’єри для викриття корупційних правопорушень, а також призводить до випадків переслідування викривачів.
Розглянуто актуальну судову практику, зокрема рішення КЦС ВС, яке підкреслює важливість захисту викривачів від негативного впливу роботодавців. В результаті проведеного дослідження відмічена готовність судів захищати права викривачів, включно із поновленням на роботі та компенсацією збитків. Така позиція судової влади сприяє зміцненню довіри до судової системи та мотивує громадян повідомляти про корупцію.
Виявлено основні проблеми: прогалини у законодавстві, відсутність ефективних механізмів реалізації гарантій та недостатню обізнаність працівників і роботодавців. Водночас наголошено на позитивних тенденціях у судовій практиці, що сприяють зміцненню довіри до судової системи. Для ефективного захисту викривачів в статті пропонується вжити заходів до вдосконалення національного законодавства, на необхідності гармонізації його з міжнародними стандартами, розробки чітких процедур захисту викривачів, посиленні відповідальності за порушення прав викривачів, створити спеціалізовані органи та впровадити міжнародні стандарти захисту викривачів.
Сучасний погляд на підстави визнання доказів недопустимими у кримінальному процесі України
Authors: Цімура Я. В. 
Published: February 2025

У статті висвітлено результати наукового дослідження сучасних підходів до визначення підстав визнання доказів недопустимими в кримінальному процесі України. Проаналізовано позиції вітчизняних науковців з зазначеного предмета дослідження. За результатами їх критичної оцінки сформульовано власний підхід до визначення кола критеріїв недопустимості доказів. У роботі також приділено увагу проблемі істотності та неістотності порушень кримінальної процесуальної форми та їх впливу на визнання доказів недопустимими у їх нерозривному зв’язку із поняттям очевидної та неочевидної недопустимості доказів. Зокрема до очевидно недопустимих доказів слід в першу чергу відносити ті фактичні дані, недопустимість яких прямо визначена законом, де це ті порушення, які безпосередньо передбачені КПК України. Доведено, що істотність порушення кримінальної процесуальної форми прямо визначена законодавцем, у зв’язку із чим суду не потрібно досліджувати істотність чи неістотність такого порушення, адже статус таких порушень презюмується законодавцем. Всі інші можливі порушення, які не презюмуються законодавцем повинні становити предмет судового дослідження щодо їх недопустимості. Вказується, що саме право суду у разі встановлення очевидної недопустимості доказу припинити його дослідження в судовому засіданні або не досліджувати взагалі є важливою гарантією використання допустимих доказів в кримінальному процесі України. Зазначено про закладену на законодавчому конструкцію презумпції істотності порушень кримінальної процесуальної форми, що породжує очевидну недопустимість доказів.
Липосомальные нанотехнологии в лечении заболеваний предстательной железы
Authors: Ниткин Д.М. 
Published: February 2025

В статье рассматриваются перспективы использования липосом в роли транспортной системы доставки лекарственных средств к органам-мишеням и возможность применения липосомальных нанотехнологий в урологии при лечении болезней предстательной железы. Отдельное внимание уделяется доказательной базе практического использования субстанций: липосомального эпигаллокатехина, дииндолилметана, бета-ситостерола, липосомального кверцетина, липосомального ресвератрола, липосомального пиридоксина, а также экстрактов лекарственных растений для лечения таких заболеваний, как хронический простатит, доброкачественная гиперплазия простаты, и для профилактики неопластических процессов в предстательной железе.
The article discusses the prospects of using liposomes as a transport system for delivering drugs to target organs and the possibility of using liposomal nanotechnology in urology in the treatment of prostate diseases. Special attention is paid to the evidence base for the practical use of substances: liposomal epigallocatechin, diindolylmethane, beta-sitosterol, liposomal quercetin, liposomal resveratrol, liposomal pyridoxine, as well as extracts of medicinal plants for the treatment of diseases such as chronic prostatitis, benign prostatic hyperplasia and for the prevention of neoplastic processes in the prostate.
Эстетрол – новая парадигма гормональной контрацепции
Authors: Гутикова Л.В. 
Published: February 2025

Статья посвящена исследованию применения эстетрола (Е4) в составе комбинированных оральных контрацептивов (КОК) и его эффектов в организме женщины. Естественный фетальный эстроген Е4 отличается высокой биодоступностью и низким риском метаболических последствий. Проанализированные данные исследований демонстрируют, что Е4 может снижать риск развития рака молочной железы, так как его действие приводит к меньшей пролиферации клеток молочной железы по сравнению с другими эстрогенами. На фоне приема Е4 сведен к минимуму риск венозной тромбоэмболии и отмечается меньшее воздействие на печеночные ферменты, что улучшает качество сексуальной жизни и дает возможность назначать КОК с Е4 женщинам, получающим постоянно ряд лекарственных препаратов, таких как статины, антиретровирусные, противосудорожные. Представленный обзор подчеркивает перспективные результаты клинических исследований, свидетельствующих об эффективности КОК на основе Е4, что доказывает высокий уровень удовлетворенности женщин. Клиническое применение КОК с Е4 улучшает качество жизни женщин, ликвидируя отрицательные последствия, связанные с сексуальной дисфункцией, и обеспечивая высокий контроль менструального цикла. Е4 как представитель третьего поколения эстрогенов в составе КОК может обеспечить в перспективе дополнительные преимущества для здоровья женщин, что в ближайшие годы станет предметом большого интереса исследователей и будет способствовать дальнейшей персонализации безопасного использования и выбора гормональной контрацепции.
The article is devoted to the study of the use of estetrol (E4) in combined oral contraceptives (COCs) and its effects in the female body. Natural fetal estrogen E4 is characterized by high bioavailability and low risk of metabolic consequences. The analyzed research data demonstrate that E4 can reduce the risk of breast cancer, since its action leads to less proliferation of breast cells compared to other estrogens. Against the background of taking E4, the risk of venous thromboembolism is minimized and there is a lesser effect on liver enzymes, which improves the quality of sexual life and makes it possible to prescribe COCs with E4 to women who constantly receive a number of drugs, such as: statins, antiretrovirals, anticonvulsants. The presented review highlights promising results of clinical studies indicating the effectiveness of COCs based on E4, which proves a high level of satisfaction of women. Clinical use of COCs with E4 improves the quality of life of women, eliminating the negative consequences associated with sexual dysfunction and providing high control of the menstrual cycle. E4 as a representative of the third generation of estrogens in the composition of a combined oral contraceptive may provide additional benefits for women’s health in the future, which in the coming years will be the subject of great interest of researchers and will contribute to further personalization of the safe use and choice of hormonal contraception.
Фертильность и нутриативные особенности
Authors: Камлюк А.М. 
Published: February 2025

В период планирования беременности образ жизни супругов, психологическая установка в семье на правильные пищевые привычки, исключение вредных и токсических влияний, обеспечение организма полезными веществами для увеличения его резервов имеют большое значение для достижения важной цели – воспроизводства здорового потомства. Пищевое поведение отражается на качестве половых клеток, как женских, так и мужских, которое во многом определяет здоровье ребенка. Вредные и токсические компоненты табачного дыма, вейп-пара, алкоголя, ряда лекарственных средств приводят к повреждениям ДНК ооцитов, сперматозоидов, эмбрионов. В результате – заметный рост обращений в клиники репродукции по поводу бесплодия и невынашивания беременности.
During the period of pregnancy planning the lifestyle of the spouses, the psychological family attitude based on rational eating habits, the exclusion of harmful and toxic influences, the provision of the body with biological substances to increase its reserves, are adjusted for the main goals – the reproduction of healthy offspring. Eating behavior affects the quality of reproductive cells, both female and male, which largely determine the health of the child. Harmful and toxic components of tobacco, vaping vapor, alcohol, and several medications lead to damage to the DNA of oocytes, sperm, and embryos. As a result, there is a noticeable increase in visits to fertility clinics regarding infertility and miscarriage.