bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function
Authors: Lu Xuan , Bai Shanshan , Feng Lu , Yan Xu , Lin Yuejun , Huang Junzhe , Liao Xulin , Wang Haixing , Li Linlong , Yang Zhengmeng , Yan Leo Yik Chun , Yang Boguang , Wang Ming , Jin Jiakang , Zong Zhixian , Jiang Zhaowei , Huang Chuiguo , Liu Chaoran , Zhang Xiaoting , Su Han , Wang Yaofeng , Lee Wayne Yuk‐Wai , Jiang Xiaohua , Tortorella Micky D. , Lin Sien , Ko Ho , Li Gang 
Published: January 2025

AbstractINTRODUCTIONAlzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their drainage function could be a potential therapeutic strategy for AD. Our proof‐of‐concept study demonstrated that cranial bone transport can improve meningeal lymphatic drainage function and promote ischemic stroke recovery.METHODSThis study defined cranial bone maneuver (CBM) technique. After osteotomy, a small circular bone flap was made and attached to an external fixator for subsequent maneuver in a controlled fashion for a defined period using 5xFAD mice.RESULTSCBM treatment improved memory functions, reduced amyloid deposits, and promoted meningeal lymphatic drainage function. CBM induced cascades of inflammatory and lymphangiogenic processes in skull and meninges. Meningeal lymphatics are indispensable elements for the therapeutic effects of CBM.DISCUSSIONCBM might be a promising innovative therapy for AD management, warranting further clinical investigation.Highlights
Cranial bone maneuver (CBM) alleviated memory deficits and amyloid depositions.
CBM promoted meningeal lymphangiogenesis and lymphatic drainage function.
The beneficial effects of CBM lasted for a long time following the CBM procedures.
CBM induced cascades of inflammatory and lymphangiogenic processes in the meninges.
Meningeal lymphatic vessels are indispensable elements for CBM therapeutic effects.
Nanocrystals with Aggregate Anionic Structure Enable Ion Transport Decoupling of Chain Segment Movement in Poly(ethylene oxide) Electrolytes
Authors: Hou Jinze , Xie Weiwei , Shang Long , Wu Shuang , Cui Yuewei , Li Yixin , Yan Zhenhua , Zhang Kai , Lu Yong , Chen Jun 
Published: January 2025

AbstractAll‐solid‐state polymer electrolytes are promising for lithium batteries, but Li+ transport in these electrolytes relies on amorphous chain segment movement, leading to low Li+ mobility and poor mechanical strength. Here we propose a novel Li+ transport mechanism mediated by PEO3:LiBF4 nanocrystals (NCPB) with the aggregate (AGG) anionic structure, which enables a change from amorphous to crystalline phase dominated ion transport in all‐solid‐state PEO/LiBF4 electrolyte. Experiments and simulations reveal that the interaction between Li+ and F in NCPB with AGG anionic structure simultaneously restricts anion transport and reorients anions within the free volume of NCPB, resulting in a three‐coordination intermediate to facilitate Li+ transport. The unique Li+ transport mechanism through NCPB makes the PEO/LiBF4 electrolyte with a high Li+ transference number (0.73) and remarkably increased mechanical strength (storage modulus >100 MPa) at 45 °C. As a result, the Li|LiFePO4 batteries with the ultrathin self‐supported PEO/LiBF4 electrolyte (10 μm) exhibit significantly improved cycle life (97 % @ 468 cycles) compared to those with PEO/LiTFSI electrolyte (failed @ 68 cycles). This work demonstrates a novel ion transport mechanism for achieving selective and rapid Li+ transport.
Taming the Ion‐Dipole Interaction via Rational Diluent Selection for Low‐Temperature Li‐Metal Batteries
Authors: Zhu Zhenglu , Li Yan , Ji Jie , Qi Xiaoqun , Pan Junqing , Ma Jiwei , Qie Long , Huang Yunhui 
Published: January 2025

AbstractDeveloping advanced electrolytes with high Li affinity is crucial for achieving long‐cycling lithium metal batteries (LMBs). However, the strong Li+‐solvent interactions in conventional electrolytes often induce difficult Li+ desolvation especially under low‐temperature conditions, resulting in the formation of fragile electrode interfaces involving solvents, and thus dissatisfactory cycling stability of LMBs. Herein, by introducing various diluents into the lithium hexafluorophosphate in 1, 2‐dimethoxyethane electrolyte, we reveal that Li+ desolvation is influenced by not only the diluent‐solvent interaction but also the diluent‐anion interaction. Based on these findings, a diluent selection parameter (DSP), which is calculated based on the product of interaction energies of diluent‐solvent/diluent‐Li+ and diluent‐anion/diluent‐Li+, is proposed for diluent selection. A diluent with a larger DSP is more favorable for promoting Li+ desolvation and improving the low‐temperature performance of LMBs. With the rationally selected 1, 2‐dichloroethane diluent (DSP=3.95), the Li
Cu cell enables high Li reversibility (98.5 % after 300 cycles). Li
LiFePO4 cell barely loses capacity at −20 °C for 300 cycles. The Li
LiNi0.8Co0.1Mn0.1O2 cell with the anode‐to‐cathode capacity ratio of 2.7 retains 87 % capacity retention after 100 cycles. This work provides new insights into taming strong Li‐solvent interactions and offers a new paradigm for advanced electrolyte design.
Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context
Authors: Payet Thomas , Astier Julien , Bournot Lorrine , Sicard Flavie , Robert Stéphane , Lacroix Romaric , Wabitsch Martin , Landrier Jean‐François , Mounien Lourdes 
Published: January 2025

AbstractInflammation of adipose tissue is a contributing factor to many chronic diseases associated with obesity. We previously showed that micronutrients such as vitamin D (VD) limited this metabolic inflammation by decreasing inflammatory markers expression including miR‐155 (microRNA‐155) or miR‐146a in different in vitro and in vivo models. These miRNAs could be incorporated into extracellular vesicles (EVs) in order to modulate the activity of target cells. Nevertheless, the role of VD on the miRNAs contained in EVs from adipose tissue in inflammatory conditions remains unclear. In this study, we used a human model of SGBS (Simpson‐Golabi‐Behmel syndrome) adipocytes preincubated with 1,25(OH)2D (the active form of VD) before an inflammatory stress with tumor necrosis factor α (TNFα). First, we confirmed by quantitative PCR that the expression of classical inflammatory factors (TNFα and chemokine ligand 2 [CCL2/MCP1]), miR‐146a, and miR‐155 was increased significantly under inflammatory conditions in SGBS cells and that VD prevented this up‐regulation. Secondly, transmission electron microscope imaging of EVs preparations in supernatant allowed visualization of small and large vesicles under these conditions. Then, EVs were obtained with isolation kit and the expression of miR‐155 and miR‐146a were measured. The expression of miR‐155 under TNFα effect was increased in EVs while miR‐146a was not detected. Moreover, we also showed that the TNFα‐mediated expression of miR‐155 in EVs was significantly reduced by a VD pre‐incubation of cells. Using miRNA PCR array, we also identified 33 miRNAs, organized in 5 clusters that were differentially regulated by TNFα and VD. Bioinformatic analysis of biological pathways revealed that the different miRNAs targeting genes that are involved in important cell process such as the regulation of transcription or protein phosphorylation. In conclusion, these results support for the first time that VD modulated the expression of miRNAs in EVs from adipocytes, which could represent a new mechanism of regulation of inflammation by micronutrients.
SDG walking or washing? A cross‐sectoral analysis of business contribution to the SDGs
Authors: Costa Roberta , Tiburzi Luigi , Morales‐Alonso Gustavo , Calabrese Armando , Rosati Francesco 
Published: January 2025

AbstractScholars and practitioners have increasingly focused on how business contribution to the Sustainable Development Goals (SDGs) is disclosed through SDG reporting. However, corporate sustainability literature and practice suggest that SDG reporting may be purely symbolic, potentially leading to SDG washing. This paper proposes two indices to detect, through their discrepancy, the presence of symbolic approaches to SDG reporting. The SDG Coverage Index measures the completeness of the disclosed SDG‐related data, while the SDG Commitment Index describes the level of detail in the disclosed data, assessed according to SDG‐related Global Reporting Initiative indicators. The paper presents a content analysis of the sustainability reports of 376 companies to measure SDG coverage and commitment. The results suggest that, although companies tend to cover a wide range of SDG‐related indicators, this does not necessarily translate into significant commitment to the SDGs, revealing the presence of symbolic approaches and potential SDG washing practices.
Social Capital and Supplier Adaptation of Social and Environmentally Sustainable Practices
Authors: Wamalwa Lucy Simani , Nang'ole Patricia Meyer , Saruchera Fanny 
Published: January 2025

ABSTRACTFirms in emerging nations face significant challenges in integrating environmental and social considerations into their supplier operations. Weak institutional frameworks, limited government support, resource constraints, high initial capital costs, a lack of expertise and restricted access to financial institutions often compound these challenges. Our study examines how adequate buyer–supplier social capital, characterised by trust, mutual respect, shared values and open communication, enhances socially and environmentally sustainable practices adoption. While the role of social capital in facilitating collaboration, knowledge exchange and innovation is recognised, its impact on suppliers' adoption of sustainable practices still needs to be explored. Our research focuses on manufacturing firms in Kenya—a representative context that exemplifies the challenges and opportunities in developing economies. Survey data from 233 manufacturing firms reveal that structural social capital significantly enhances suppliers' social and environmental sustainability. Relational social capital significantly influences suppliers' adoption of sustainable practices, but only when reciprocity and mutual friendship are strong. Conversely, cognitive social capital has a limited effect on adopting these practices. These findings provide new insights into sustainable supply chain implementation dynamics in developing countries and highlight the roles of various forms of social capital in promoting sustainability.
Common statistical errors in systematic reviews: A tutorial
Authors: Kanellopoulou Afroditi , Dwan Kerry , Richardson Rachel 
Published: January 2025

AbstractThe aim of this article is to present the most common statistical errors in meta‐analyses included in systematic reviews; these are confusing standard deviation and standard error, using heterogeneity estimators for choosing between a common‐effect and random‐effects model, improper handling of multiarm trials, and unnecessary and misinterpreted subgroup analyses. We introduce some useful terminology and explain what authors can do to avoid these errors and how peer reviewers can spot them. We have also developed a micro‐learning module to provide practical hands‐on tutorial.
Progress in Double Dearomatization Reactions
Authors: Liu Xihong , Zhang Jingying 
Published: January 2025

AbstractDearomatization reactions are among the most straightforward and efficient methods for creating sp3‐rich cyclic systems from simple, readily available arenes. These reactions have been widely applied in the total synthesis of natural products, medicinal chemistry, and material sciences. The fruitful development of dearomatization strategies and methodologies targeting single aromatic substrate over the past decades has paved the way for more sophisticated multiple dearomatization processes, which offer greater advantages in constructing molecular complexity. Double dearomatization reactions have made significant pioneering strides in recent years. This review will provide an overview of the strategies and detailed examples of multiple dearomatization reactions involving various aromatic compounds, along with a discussion of the related mechanisms and the major challenges that remain in this intriguing yet formidable field.
Predictors of revision endoscopic sinus surgery in Finnish patients with chronic rhinosinusitis with nasal polyps
Authors: Toppila‐Salmi Sanna , Lyly Annina , Simin Johanna , Aakko Juhani , Olsen Helga Haugom , Lehtimäki Lauri 
Published: January 2025

AbstractBackgroundAlthough patients with chronic rhinosinusitis with nasal polyps (CRSwNP) may benefit from endoscopic sinus surgery (ESS), some patients will experience polyp recurrence, adding to the overall disease burden of CRSwNP. We aimed to investigate predictors of revision ESS in patients with CRSwNP.MethodsA nationwide population‐based study including all adults diagnosed with CRSwNP who had surgical procedure codes for ESS (N = 3506), followed up between January 2012 and December 2019. Logistic regression models provided adjusted odds ratios (OR) with 95% confidence intervals (CIs) for the odds of revision surgery within one and 3 years post‐index surgery.Results559 (15.9%) of the patients had at least one revision surgery during the follow‐up. Median time to revision of ESS was 425 days (interquartile range: 213–898). Baseline asthma (OR = 1.58, 95% CI 1.17–2.12) and antibiotic use (OR = 1.61, 95% CI 1.27–2.04) were associated with higher odds of revision ESS, particularly within 3 years post‐index surgery, whereas Increasing age was inversely associated with the odds of ESS revision (OR = 0.82, 95% CI 0.76–0.88). The highest odds of revision ESS were observed within 3 years post‐index surgery in patients who had undergone extensive surgery at index (OR = 14.13, 95% CI 3.41–95.64) compared with those who had undergone limited surgery. OCS use was frequent among CRSwNP patients, with a higher cumulative dose in patients undergoing multiple ESS revisions (63%, n = 97, median daily dose 3.29 mg, IQR: 1.64–3.70) compared with patients without revisions (49%, n = 1361 and 1.64 mg, IQR: 1.64–3.29, respectively. p‐value <0.001).ConclusionsA small proportion of CRSwNP patients require revision ESS with associated high cumulative OCS doses, highlighting the need for additional therapies to achieve disease control and reduce the corticosteroid burden. A few simple baseline characteristics can predict the need for recurrent surgery among the patients with CRSwNP.
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands
Authors: Cosentino Giuseppe , Dichiara Maria , Costanzo Giuliana , Coco Alessandro , Pasquinucci Lorella , Marrazzo Agostino , Rescifina Antonio , Amata Emanuele 
Published: January 2025

AbstractThis study presents a series of tetrahydropyrrolo[3,4‐c]pyrazole‐based compounds designed as sigma‐1 receptor (S1R) ligands, focusing on optimizing affinity and reducing off‐target effects. We synthesized various derivatives from commercially available precursors and, through radioligand binding assays, assessed their binding affinity for S1R and sigma‐2 receptor (S2R). Compound 19 (AD417), containing a benzyl group and an amide substituent, demonstrated notable S1R affinity (Ki=75 nM) with 6‐fold selectivity over S2R. Modifications on the pyrrolidine nitrogen were crucial in enhancing receptor interaction, as the protonated nitrogen likely interacts with Glu172 within the S1R binding site. Furthermore, to address hERG potassium ion channel inhibition, a known limitation in S1R drug development, we evaluated compound 19’s cardiotoxicity potential. With an experimental hERG IC50 of 5.8 μM, significantly higher than verapamil's IC50 of 0.41 μM, and haloperidol's IC50 of 0.16 μM, compound 19 showed a safer profile, suggesting a reduced risk of cardiotoxicity. These findings underscore the role of nitrogen accessibility, structural flexibility, and functional group modifications in optimizing S1R ligand interactions and provide a promising foundation for developing safer S1R‐targeted therapeutics with minimized hERG‐related risks.
Solvent Effect on Antimicrobial Hydrophilic Xerogel Coating of Medicinal Leathers in Simulated Industrial Finishing Process
Authors: Bompotis Theofanis , Karastergiou Eirini , Giannakopoulos Konstantinos , Favvas Evangelos P. , Arvanitopoulou Marina , Arvanitopoulos Konstantinos , Arvanitopoulos Labros , Kytherioti Georgia , Vardavoulias Michail , Giannakoudakis Dimitrios A. , Castellsagués Laura , Soto González. Sara Maria , Arkas Michael 
Published: January 2025

AbstractThe hydrophilic character and the protection against pathogen proliferation are the most pivotal characteristics of leathers intended for medical purposes. To achieve these goals, dispersions of TiO2 particles incorporating three different formulations of biomimetically synthesized silica xerogels were tested. Emphasis has been given to the role of single and dual solvents employed. Microbiocide capability was induced by benzalkonium chloride along with silver nanoparticles. Particular emphasis should be given to hyperbranched poly(ethylene imine) multifunctional roles. Spontaneous mineralization of silver ions is realized in the dendritic cavities. The same polymer acts as a matrix that interacts with the hydrogen bonding network of orthosilicic acid directing and facilitating gel formation. Furthermore, it contributes to both hydrophilicity and antimicrobial properties. Gel formation and subsequent drying occur in the pores of the impregnated TiO2 substrate. The resistance of the leathers to fungal and bacterial infections and biofilm formation was assessed against Klebsiella Pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and Candida albicans. The affinity to water was proved by the contact angle method. The proposed treatment is a prospective environmentally friendly replacement to the standard finishing process of medical leathers.
Age‐disproportionate atrophy in Alzheimer's disease and Parkinson's disease spectra
Authors: Yoshinaga Kenji , Matsushima Toma , Abe Mitsunari , Takamura Tsunehiko , Togo Hiroki , Wakasugi Noritaka , Sawamoto Nobukatsu , Murai Toshiya , Mizuno Toshiki , Matsuoka Teruyuki , Kanai Kazuaki , Hoshino Hiroshi , Sekiguchi Atsushi , Fuse Nobuo , Mugikura Shunji ,   Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMMbMRI)Parkinson's and Alzheimer's disease Dimensional Neuroimaging Initiative (PADNI), Hanakawa Takashi 
Published: January 2025

AbstractINTRODUCTIONBrain age gap (BAG), defined as the difference between MRI‐predicted ‘brain age’ and chronological age, can capture information underlying various neurological disorders. We investigated the pathophysiological significance of the BAG across neurodegenerative disorders.METHODSWe developed a brain age estimator using structural MRIs of healthy‐aged individuals from one cohort study. Subsequently, we applied this estimator to people with Alzheimer's disease spectra (AD) and Parkinson's disease (PD) from another cohort study. We investigated brain sources responsible for BAGs among these groups.RESULTSBoth AD and PD exhibited a positive BAG. Brain sources showed overlapping, yet partially segregated, neuromorphological differences between these groups. Furthermore, employing with t‐distributed stochastic neighbor embedding on the brain sources, we subclassified PD into two groups with and without cognitive impairment.DISCUSSIONOur findings suggest that brain age estimation becomes a clinically relevant method for finely stratifying neurodegenerative disorders.Highlights
Brain age estimated from structure MRI data was greater than chronological age in patients with Alzheimer's disease/mild cognitive impairment or Parkinson's disease.
Brain regions attributed to brain age estimation were located mainly in the fronto‐temporo‐parietal cortices but not in the motor cortex or subcortical regions.
Brain sources responsible for the brain age gaps revealed roughly overlapping, yet partially segregated, neuromorphological differences between participants with Alzheimer's disease/mild cognitive impairment and Parkinson's disease.
Participants with Parkinson's disease were subclassified into two groups (with and without cognitive impairment) based on brain sources responsible for the brain age gaps.
Andrographolide Mitigates Cisplatin Resistance by Inhibiting SPP1 Regulated NF‐kB/iNOS/COX‐2 and PI3K/AKT Pathway in Cisplatin Resistant Cervical Carcinoma Cells
Authors: Pasha Akbar , Ravinder Doneti , Pawar Smita C. 
Published: January 2025

ABSTRACTDrug resistance and cancer recurrence are major cause of Cervical cancer (CC) patient mortality. Cisplatin (CDDP) is the major drug that has been extremely used in all stages in treating CC, although relapse and malignant instances have been observed as a result of cisplatin resistance in CC. In the present study, we established Cisplatin resistant CC HeLa cell line model and the cytotoxic effects of Andro as a single agent or in combination with CDDP were investigated to assess its potential as a chemotherapeutic agent in cisplatin‐resistant HeLa (CisR‐HeLa) cells. Andro enhanced the cytotoxicity of CDDP in CisR‐HeLa cells and shown a synergistic effect by reducing cell viability, proliferation, migration, invasion, and inducing apoptosis in cisplatin resistant cells. Furthermore, we evaluated the expression levels of inflammatory and oncogenic proteins, SPP1, NF‐kB, iNOS, COX‐2, and the PI3K/AKT signaling pathway, which are associated with cisplatin resistance, as well as using Andro to regulate the targeted markers in CisR‐HeLa cells to overcome resistance. The results show that suppressing SPP1 and NF‐kB by Andro alone or in combination with CDDP regulates iNOS, COX‐2, and increases PTEN expression. The addition of Andro to CDDP inhibited PI3K and AKT expression as well as triggered synergistic apoptosis, which could be associated with variations in Bax and Bcl‐2 protein levels. The results suggest that Andro in combination with CDDP exhibits synergistic anti‐tumor growth efficacy that targets multiple inflammatory markers, resulting in a promising treatment option for individuals with recurrent cancer due to drug resistance and advanced CC.