bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐invasive oral implant position assessment: An ex vivo study using a 3D industrial scan as the reference model to mimic the clinical situation
Authors: Tarce Mihai , Becker Kathrin , Lahoud Pierre , Shujaat Sohaib , Jacobs Reinhilde , Quirynen Marc 
Published: November 2023

AbstractAimTo introduce an objective method to evaluate the accuracy of implant position assessment in partially edentulous patients by comparing different techniques (conventional impression, intraoral scan, CBCT) to a reference 3D model obtained with an industrial scanner, the latter mimicking the clinical situation.Materials and MethodsTwenty‐nine implants were placed in four human cadaver heads using a fully guided flapless protocol. Implant position was assessed using (a) a conventional impression, (b) an intraoral scan, and (c) CBCT and compared to an industrial scan. Three‐dimensional models of intraoral scan body and implant were registered to the arch models and the deviation at implant shoulder, apex, and the angle of deviation were compared to each other as well as to the reference model.ResultsThe three assessment techniques showed statistically significant deviations (p < .01) from the industrial scan, for all measurements, with no difference between the techniques. The maximum deviation at the implant shoulder was 0.16 mm. At the implant apex this increased to 0.38 mm. The intraoral scan deviated significantly more than the CBCT (0.12 mm, p < .01) and the conventional impression (0.10 mm, p = .02). The maximum implant angle deviation was 1.0°. The intraoral scan deviated more than the conventional impression (0.3°, p = .02).ConclusionAll assessment techniques deviated from the reference industrial scan, but the differences were relatively small. Intraoral scans were slightly less accurate than both conventional impressions and CBCT. Depending on the application, however, this inaccuracy may not be clinically relevant.
A TTC19 mutation associated with progressive movement disorders and peripheral neuropathy: Case report and systematic review
Authors: Xuan Xianjun , Ruan Jie , Wu Chunhong , Gao Yiyi , Li Lingfei , Lei Xiaoguang 
Published: November 2023

AbstractBackgroundMitochondrial complex III (CIII) deficiency is an autosomal recessive disease characterized by symptoms such as ataxia, cognitive dysfunction, and spastic paraplegia. Multiple genes are associated with complex III defects. Among them, the mutation of TTC19 is a rare subtype.MethodsWe screened a Chinese boy with weakness of limbs and his non‐consanguineous parents by whole exome sequencing and targeted sequencing.ResultsWe report a Chinese boy diagnosed with mitochondrial complex III defect type 2 carrying a homozygous variant (c.719‐732del, p.Leu240Serfs*17) of the TTC19 gene. According to the genotype analysis of his family members, this is an autosomal recessive inheritance. We provide his clinical manifestation.ConclusionsA new type of TTC19 mutation (c.719‐732del, p.Leu240Serfs*17) was found, which enriched the TTC19 gene mutation spectrum and provided new data for elucidating the pathogenesis of CIII‐deficient diseases.
Glomerular and tubular effects of dapagliflozin, eplerenone and their combination in patients with chronic kidney disease: A post‐hoc analysis of the ROTATE‐3 study
Authors: Lieverse Tom T. G. F. , Puchades Maria J. , Mulder Udo D. J. , Provenzano Michele , Krenning Guido , Jongs Niels , Wink Simon E. , Slart Riemer H. J. A. , Andreucci Michele , D'Marco Luis , De Nicola Luca , Gorriz Jose L. , Heerspink Hiddo J. L. 
Published: November 2023

AbstractAimSodium‐glucose co‐transporter 2 inhibitors and mineralocorticoid receptor antagonists reduce albuminuria and the risk of kidney failure. The aim of this study was to investigate the effects of both agents alone and in combination on markers of the glomerular endothelial glycocalyx and tubular function.MethodsThis post‐hoc analysis utilized data of the ROTATE‐3 study, a randomized cross‐over study in 46 adults with chronic kidney disease and urinary albumin excretion ≥100 mg/24 h, who were treated for 4 weeks with dapagliflozin, eplerenone or its combination. The effects of dapagliflozin, eplerenone and the combination on outcome measures such as heparan sulphate, neuro‐hormonal markers and tubular sodium handling were assessed with mixed repeated measures models.ResultsThe mean percentage change from baseline in heparan sulphate after 4 weeks treatment with dapagliflozin, eplerenone or dapagliflozin‐eplerenone was −34.8% (95% CI −52.2, −10.9), −5.9% (95% CI −32.5, 31.3) and −28.1% (95% CI −48.4, 0.1) respectively. The mean percentage change from baseline in plasma aldosterone was larger with eplerenone [38.9% (95% CI 2.8, 87.7)] and dapagliflozin‐eplerenone [32.2% (95% CI −1.5, 77.4)], compared with dapagliflozin [−12.5% (95% CI −35.0, 17.8)], respectively. Mean percentage change from baseline in copeptin with dapagliflozin, eplerenone or dapagliflozin‐eplerenone was 28.4% (95% CI 10.7, 49.0), 4.2% (95% CI −10.6, 21.4) and 23.8% (95% CI 6.6, 43.9) respectively. Dapagliflozin decreased proximal absolute sodium reabsorption rate by 455.9 mmol/min (95% CI −879.2, −32.6), while eplerenone decreased distal absolute sodium reabsorption rate by 523.1 mmol/min (95% CI −926.1, −120.0). Dapagliflozin‐eplerenone decreased proximal absolute sodium reabsorption [−971.0 mmol/min (95% CI −1411.0, −531.0)], but did not affect distal absolute sodium reabsorption [−9.2 mmol/min (95% CI −402.0, 383.6)].ConclusionsDapagliflozin and eplerenone exert different effects on markers of glomerular and tubular function supporting the hypothesis that different mechanistic pathways may account for their kidney protective effects.
Platelet‐associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity
Authors: Duran‐Bertran Joan , Rusu Elena Cristina , Barrientos‐Riosalido Andrea , Bertran Laia , Mahmoudian Razieh , Aguilar Carmen , Riesco David , Martínez Salomé , Ugarte Chicote Javier , Sabench Fàtima , Richart Cristóbal , Auguet Teresa 
Published: November 2023

AbstractBackgroundThere is a lack of noninvasive diagnostic methods for nonalcoholic steatohepatitis (NASH), the severe condition of metabolic dysfunction‐associated steatotic liver disease (MASLD). Platelet activation, evaluated through certain related parameters, is associated with liver disease and inflammation, but previous results are inconclusive.AimTo investigate the potential utility of platelet‐related indices as noninvasive diagnostic markers for the detection and prediction of MASLD, focusing on NASH.ResultsWe found that mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW) were increased in the severe and morbidly obese (SMO) group compared to the normal weight (NW) group. We found decreased levels of MPV in steatosis and NASH patients. MPV and PCT values were decreased in the presence of mild liver inflammation. Platelet count (PLA) and PCT values were lower in the presence of ballooning. We obtained an area under the ROC curve of 0.84 using MPV and three other variables to predict MASLD.ConclusionsSome platelet‐related indices vary depending on liver condition. Here, we reported decreased MPV in MASLD presence. Moreover, we presented for the first time a predictive model using MPV, ALT levels and the presence of diabetes mellitus and metabolic syndrome to predict MASLD in obese women. Also, MPV is closely related to early liver inflammation in NASH, and PLA and PCT are related to hepatic ballooning. These indices could be widely used for the early detection of NASH since they are usually determined in routine laboratory tests.
New evidence on crude oil market efficiency
Authors: Hu Liang , Lee Yoon‐Jin 
Published: November 2023

AbstractThis paper examines the Efficient Market Hypothesis (EMH) in crude oil amid the “financialization of commodity markets” and the “fracking revolution”. It applies the generalized spectral derivative test (Hong and Lee 2005) on both West Texas Intermediate and Brent spot and futures markets, alongside a stochastic dominance test (Linton et al., 2005) to investigate arbitrage opportunities across markets and benchmarks. The findings indicate that financialization has made each market more efficient but also created more arbitrage opportunities in spot‐futures markets at both benchmarks. The fracking revolution has fragmented oil markets but had little impact on EMH in individual markets or across markets.
Impact and management of Opogona sacchari (Bojer, 1856) (Lepidoptera: Tineidae) in a display glasshouse in the United Kingdom
Authors: Drizou Fryni , Redstone Sara , Salisbury Andrew 
Published: November 2023

AbstractOpogona sacchari (Bojer, 1856), or the banana moth, EPPO code OPOGSC, is an EPPO A2‐listed polyphagous insect. In Northern Europe this pest is mainly confined to glasshouses. The Royal Horticultural Society (RHS) Garden Wisley is located in Surrey, GB. In 2007, a new high‐specification glasshouse was built to host plants from temperate and tropical zones. Soon after the opening of the glasshouse to the public, the banana moth was detected. Different methods were used to understand and manage this infestation, which caused significant losses of plant specimens. Here we share our experience of different management approaches, a list of plants damaged or killed by the insect and our main conclusions on tackling future outbreaks.
Keratinocyte proline‐rich protein modulates immune and epidermal response in imiquimod‐induced psoriatic skin inflammation
Authors: Matsuno Ai , Sumida Hayakazu , Nakanishi Hirofumi , Ikeyama Yoshifumi , Ishii Tsuyoshi , Omori Issei , Saito Hinako , Iwasawa Okuto , Sugimori Ayaka , Yoshizaki Ayumi , Katoh Hiroto , Ishikawa Shumpei , Sato Shinichi 
Published: November 2023

AbstractPsoriasis is a persistent inflammatory skin disease thought to arise as a result of the infiltration of inflammatory cells and activation of keratinocytes. Recent advances in basic research and clinical experience revealed that the interleukin (IL)‐23/IL‐17 axis has been identified as a major immune pathway in psoriasis. However, it remains unclear how keratinocyte factors contribute to the pathology of psoriasis. Keratinocyte proline‐rich protein (KPRP) is a proline‐rich insoluble protein, which is present in the epidermis and is likely to be involved in the skin barrier function. Here, to investigate the potential roles of KPRP in psoriatic skin inflammation, Kprp‐modified mice were applied in the imiquimod (IMQ)‐induced skin inflammation model, which develops psoriasis‐like epidermal hyperplasia and cutaneous inflammation features. Then, heterozygous knockout (Kprp+/−) but not homozygous knockout (Kprp−/−) mice displayed attenuated skin erythema compared to control wild‐type mice. In addition, RNA sequencing, quantitative PCR and/or histological analysis detected changes in the expression of several molecules related to psoriatic inflammation or keratinocyte differentiation in Kprp+/− mice, but not Kprp−/− mice. Further analysis exhibited reduced IL‐17‐producing γδlow T cells and amplified epidermal hyperplasia in Kprp+/− mice, which were implied to be related to decreased expression of β‐defensins and increased expression of LPAR1 (Lysophosphatidic acid receptor 1), respectively. Thus, our results imply that KPRP has the potential as a therapeutic target in psoriatic skin inflammation.
Serum miRNA profiling identified miRNAs associated with disease severity in psoriasis
Authors: Ganguly Torsa , Laha Sayantan , Senapati Swapan , Chatterjee Gobinda , Chatterjee Raghunath 
Published: November 2023

AbstractPsoriasis vulgaris is a chronic, autoimmune skin disease involving a complex interplay of epidermal keratinocytes, dermal fibroblast and infiltrating immune cells. Differential expressions of miRNAs are observed in psoriasis and the deregulated miRNAs are sometimes associated with disease severity. This study aims to identify miRNAs altered in the serum of psoriasis patients that are associated with the Psoriasis Area and Severity Index (PASI). In order to assess miRNA levels in the serum of psoriasis patients, we selected 24 differentially expressed miRNAs in the psoriatic skin are possibly derived from the skin and immune cells, as well as five miRNAs that are enriched in other tissues. We identified 16 miRNAs that exhibited significantly (p < 0.05) altered levels in the serum of psoriasis patients compared to healthy individuals. Among these, 13 miRNAs showed similar expression pattern in the serum of psoriasis patients as also observed in the psoriatic skin tissues. Ten miRNAs showed an accuracy of greater than 75% in classifying the psoriasis patients from healthy individuals. Further analysis of differential miRNA levels between the low PASI group and the high PASI group identified three miRNAs (miR‐147b, miR‐3614‐5p, and miR‐125a‐5p) with significantly altered levels between the low severity and the high severity psoriasis patients. Our systematic investigation of skin and immune cell‐derived miRNAs in the serum of psoriasis patients revealed alteration in miRNA levels to be associated with disease severity, which may help in monitoring the disease progression and therapeutic response.
Weighted gene co‐expression network analysis and machine learning identified the lipid metabolism‐related gene LGMN as a novel biomarker for keloid
Authors: Wang Qirui , Huang Xingtai , Zeng Siyi , Zhou Renpeng , Wang Danru 
Published: November 2023

AbstractThe aetiology of keloid formation remains unclear, and existing treatment modalities have not definitively established a successful approach. Therefore, it is necessary to identify reliable and novel keloid biomarkers as potential targets for therapeutic interventions. In this study, we performed differential expression analysis and functional enrichment analysis on the keloid related datasets, and found that multiple metabolism‐related pathways were associated with keloid formation. Subsequently, the differentially expressed genes (DEGs) were intersected with the results of weighted gene co‐expression network analysis (WGCNA) and the lipid metabolism‐related genes (LMGs). Then, three learning machine algorithms (SVM‐RFE, LASSO and Random Forest) together identified legumain (LGMN) as the most critical LMGs. LGMN was overexpressed in keloid and had a high diagnostic performance. The protein–protein interaction (PPI) network related to LGMN was constructed by GeneMANIA database. Functional analysis of indicated PPI network was involved in multiple immune response‐related biological processes. Furthermore, immune infiltration analysis was conducted using the CIBERSORT method. M2‐type macrophages were highly infiltrated in keloid tissues and were found to be significantly and positively correlated with LGMN expression. Gene set variation analysis (GSVA) indicated that LGMN may be related to promoting fibroblast proliferation and inhibiting their apoptosis. Moreover, eight potential drug candidates for keloid treatment were predicted by the DSigDB database. Western blot, qRT‐PCR and immunohistochemistry staining results confirmed that LGMN was highly expressed in keloid. Collectively, our findings may identify a new biomarker and therapeutic target for keloid and contribute to the understanding of the potential pathogenesis of keloid.
Transcriptomics reveal how circadian regulation contributes to starch hyperaccumulation in marine alga Tetraselmis helgolandica
Authors: Shi Qianwen , Zhou Zuodong , Hong Zhiwei , Yang Zhi , Gao Zhengquan , Sun Liyun , Fan Jianhua 
Published: November 2023

AbstractTetraselmis helgolandica var. Tsingtaoensis is a marine microalga. It can produce a large amount of starch, especially amylose, with addition of carbon source and specific circadian rhythm. The mechanism behind this phenomenon is still unclear. Analysis of this mechanism can help to develop T. helgolandica into a new green bioengineering chassis organism. We explained how circadian rhythm and glucose affect the rate of starch accumulation and starch structure in T. helgolandica based on the transcriptome. The glucose inhibited the photosynthetic system of T. helgolandica, while the circadian rhythm can alleviate the inhibition. Circadian rhythm induced the upregulation of Embden–Meyerhof–Parnas pathway and pentose phosphate pathway (PPP) in T. helgolandica, but had little effect on the tricarboxylic acid cycle. PPP pathway provides Ribulose‐1,5‐bisphosphate, which may be beneficial for dark reactions and nucleotide synthesis. And PPP pathway provides Nicotinamide adenine dinucleotide phosphate, which facilitates energy substance synthesis. This will further upregulate the starch metabolic pathway. The transcript level of the key gene ADP‐Glucose pyrophosphorylase is mainly regulated by glucose. The granule‐bound starch synthase (gbss), a key gene for amylose synthesis, is mainly influenced by circadian rhythm. In general, the increase of starch synthesis and amylose ratio requires both glucose addition and circadian rhythm. We report the first referenced transcriptome of T. helgolandica. Differences between transcripts reveal how circadian rhythm and glucose addition affected the rate of starch synthesis and structural variation. It provides a reference for an in‐depth study of starch synthesis in green algae.
Linkage‐ and structure‐based technological proximity and interregional spillovers of innovation growth
Authors: Li Yuanxi , Sun Tieshan , Sun Yukang 
Published: November 2023

AbstractThis paper explores the roles of different types of technological proximity on the interregional spillovers of innovation growth. Using a panel dataset containing Chinese province patents and R&D inputs from 2002 to 2019, this paper estimates a knowledge production function with the spatial weight matrices constructed based on the linkage‐based and structure‐based technological proximity. We find that the two types of technological proximity are significantly different and their contributions to interregional innovation spillovers differ. The structure‐based proximity shows a lower influence on spillovers and its effect in the process of interregional innovation spillovers is affected by the regional development level. This paper originates to clarify two conceptualizations of technological proximity, compare their influences on innovation spillovers, and explore their regional differences.
Presence of leukemic clone‐specific immunoglobulin heavy chain rearrangements in neonatal blood spots of children with B‐cell precursor acute lymphoblastic leukemia
Authors: Kacanski Natasa , Kolarovic Jovanka , Kostic Tatjana , Marjanovic Irena , Janic Dragana , Pavlovic Sonja , Karan‐Djurasevic Teodora 
Published: November 2023

AbstractIntroductionChildhood B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) can be traced back to birth using leukemic clone‐specific immunoglobulin heavy chain (IGH) rearrangements, implying prenatal origin of this disease.MethodsWe retrospectively analyzed neonatal blood spots (Guthrie cards) of 24 patients with childhood BCP‐ALL aged 1–9.6 years (median 3.1 years) for the presence of clonotypic IGH rearrangements identified in diagnostic bone marrow samples. Based on the sequences of IGH rearrangements, 2 patient‐specific primers were designed for each patient and used in semi‐nested polymerase chain reaction for the detection of preleukemic clones at birth.ResultsClonotypic IGH rearrangements were detected in neonatal blood spots of 54.2% of patients (13/24). In two cases with double IGH rearrangements detected at diagnosis, only one rearrangement was present at birth, while in the third case both leukemic rearrangements were detected in neonatal blood. Guthrie card‐positive findings were significantly more frequent in children ≤5 years of age than in older children (p = 0.011). Regarding patients' characteristics at birth and at diagnosis, Guthrie card‐positivity was not associated with sex, birth weight and mother's age, as well as with white blood cell count, percentage of bone marrow blasts, immunophenotype and the presence of ETV6/RUNX1 and TCF3/PBX1 fusion genes at diagnosis.ConclusionOur study confirms that a large proportion of childhood BCP‐ALL originates in utero, regardless of the molecular subtype defined by chromosomal aberrations. The observed trend toward younger age at diagnosis in Guthrie card‐positive versus Guthrie card‐negative patients implies that the age at diagnosis depends on the presence of preleukemic clone at birth, as well as on the timing of postnatal transforming genetic events.
Transvenous versus subcutaneous implantable cardioverter defibrillators in young cardiac arrest survivors
Authors: Morton Matthew B. , Mariani Justin A. , Kistler Peter M. , Patel Hitesh , Voskoboinik Aleksandr 
Published: November 2023

AbstractSecondary prevention implantable cardioverter defibrillators (ICDs) are indicated in young patients presenting with aborted sudden cardiac death (SCD) because of ventricular arrhythmias. Transvenous‐ICDs (TV‐ICDs) are effective, established therapies supported by evidence. The significant morbidity associated with transvenous leads led to the development of the newer subcutaneous‐ICD (S‐ICD). This review discusses the clinical considerations when selecting an ICD for the young patient presenting with out‐of‐hospital cardiac arrest. The major benefits of TV‐ICDs are their ability to pace (antitachycardia pacing [ATP], bradycardia support and cardiac resynchronisation therapy [CRT]) and the robust evidence base supporting their use. Other benefits include a longer battery life. Significant complications associated with transvenous leads include pneumothorax and tamponade during insertion and infection and lead failure in the long term. Comparatively, S‐ICDs, by virtue of having no intravascular leads, prevent these complications. S‐ICDs have been associated with a higher incidence of inappropriate shocks. Patients with an indication for bradycardia pacing, CRT or ATP (documented ventricular tachycardia) are seen as unsuitable for a S‐ICD. If venous access is unsuitable or undesirable, S‐ICDs should be considered given the patient is appropriately screened. There is a need for further randomised controlled trials to directly compare the two devices. TV‐ICDs are an effective therapy for preventing SCD limited by significant lead‐related complications. S‐ICDs are an important development hindered largely by an inability to pace. Young patients stand to gain the most from a S‐ICD as the cumulative risk of lead‐related complications is high. A clinical framework to aid decision‐making is presented.
Self‐Destructive Consequences of Sex‐Role Socialization
Authors: Clifton A. Kay , Lee Dorothy E. 
Published: November 2023

ABSTRACTSuicide proneness and self‐destruction scales, together with measures of self‐favorability and self‐confidence, were administered to two samples (n = 106 and n = 213). The affective responses of the second sample (134 women and 79 men) were measured by asking respondents to circle adjectives classified for activity‐passivity, positive‐negativeness, and extroversion‐introversion that expressed their feelings toward eight situations. Women scored lower than men on suicide proneness, higher on self‐destruction, and lower on self‐favorability and self‐confidence. Women reacted more passively to the situations than men and more negatively to the public challenge situation. Women tend to extrovert (turn outward on others) their positive feelings in pleasant situations and to introvert (turn blame on themselves) their negative reactions to unpleasant situations. Men do the reverse. It is suggested that women are self‐destructive in passive ways, reflecting their lack of self‐favorability and confidence and manifested by failure to react to everyday situations in ego‐building ways.