bluuebunny/crossref_metadata_2025_split huggingface dataset:
Next-to-next-to-leading-order QCD corrections to double J/ψ production at the B factories
Authors: Huang Xu-Dong , Gong Bin , Niu Rui-Chang , Yu Huai-Min , Wang Jian-Xiong 
Published: February 2024

Abstract
In this paper, we study the next-to-next-to-leading-order (NNLO) QCD corrections for the process e+e− → J/ψ + J/ψ at the B factories. By including the NNLO corrections, the cross section turns negative due to the poor convergence of perturbative expansion. Consequently, to obtain a reasonable estimation for the cross section, the square of the amplitude up to NNLO is used. In addition, the contributions from the bottom quark and the light-by-light part, which are usually neglected, are also included. The final cross section is obtained as $$ {1.76}_{-1.66}^{+2.42} $$

1.76

−
1.66

+
2.42

fb at a center-of-mass energy of $$ \sqrt{s} $$

s

= 10.58 GeV. Our result for total cross section and differential cross section could be compared with precise experimental measurement in future at the B factories.
Consumers preferences food safety perceptions for beef – a cross-country comparison in the wake of COVID-19
Authors: Meixner Oliver , Haas Rainer , Imami Drini , Miftari Iliriana 
Published: February 2024

AbstractFood safety is a pressing global concern, particularly in developing and emerging economies. The recent COVID-19 pandemic has further heightened consumer attention towards food safety, quality, and maintaining a healthy diet. This study provides insights into consumer awareness and perceptions related to food safety and the origin of beef products, with a specific focus on the impact of COVID-19. It draws comparisons between emerging economies, specifically Albania and Kosovo, where significant food safety challenges exist, and a highly developed economy, Austria. To assess consumer preferences, a discrete choice experiment was conducted, aiming to gauge the significance of various product attributes and consumers’ willingness to pay (WTP) for specific product features. The study’s findings revealed a strikingly strong sense of consumer patriotism across all surveyed countries. WTP estimates indicated a clear preference for domestically sourced food over imported alternatives. While the COVID-19 pandemic exerted a notable influence, its effects were generally contained. However, respondents from emerging economies perceived the pandemic’s impact to be more severe. Additionally, factors such as risk perception and risk acceptance played a role in shaping the importance of relevant product attributes in all the food markets examined in this study. Furthermore, distinct variations emerged between the countries concerning the importance of food safety standards. For instance, in Albania, the European Union (EU) food safety certificate holds higher utility compared to the national certificate, suggesting a potential lack of trust in national agencies. Notably, low trust in institutions, including those related to food safety, is a common issue in emerging and developing economies. This lack of trust, in turn, influences consumers’ perceptions of personal food safety, given that it is a credence attribute.
Exploring the nexus of nuclear receptors in hematological malignancies
Authors: Manickasamy Mukesh Kumar , Sajeev Anjana , BharathwajChetty Bandari , Alqahtani Mohammed S. , Abbas Mohamed , Hegde Mangala , Aswani Babu Santha , Shakibaei Mehdi , Sethi Gautam , Kunnumakkara Ajaikumar B. 
Published: February 2024

AbstractHematological malignancies (HM) represent a subset of neoplasms affecting the blood, bone marrow, and lymphatic systems, categorized primarily into leukemia, lymphoma, and multiple myeloma. Their prognosis varies considerably, with a frequent risk of relapse despite ongoing treatments. While contemporary therapeutic strategies have extended overall patient survival, they do not offer cures for advanced stages and often lead to challenges such as acquisition of drug resistance, recurrence, and severe side effects. The need for innovative therapeutic targets is vital to elevate both survival rates and patients' quality of life. Recent research has pivoted towards nuclear receptors (NRs) due to their role in modulating tumor cell characteristics including uncontrolled proliferation, differentiation, apoptosis evasion, invasion and migration. Existing evidence emphasizes NRs' critical role in HM. The regulation of NR expression through agonists, antagonists, or selective modulators, contingent upon their levels, offers promising clinical implications in HM management. Moreover, several anticancer agents targeting NRs have been approved by the Food and Drug Administration (FDA). This review highlights the integral function of NRs in HM's pathophysiology and the potential benefits of therapeutically targeting these receptors, suggesting a prospective avenue for more efficient therapeutic interventions against HM.
Graphical abstract
METTL16 inhibits papillary thyroid cancer tumorigenicity through m6A/YTHDC2/SCD1-regulated lipid metabolism
Authors: Li Qiang , Wang Yaju , Meng Xiangshu , Wang Wenjing , Duan Feifan , Chen Shuya , Zhang Yukun , Sheng Zhiyong , Gao Yu , Zhou Lei 
Published: February 2024

AbstractPapillary thyroid carcinoma (PTC) stands as the leading cancer type among endocrine malignancies, and there exists a strong correlation between thyroid cancer and obesity. However, the clinical significance and molecular mechanism of lipid metabolism in the development of PTC remain unclear. In this study, it was demonstrated that the downregulation of METTL16 enhanced lipid metabolism and promoted the malignant progression of PTC. METTL16 was expressed at lower levels in PTC tissues because of DNMT1-mediated hypermethylation of its promoter. Loss- and gain-of-function studies clarified the effects of METTL16 on PTC progression. METTL16 overexpression increased the abundance of m6A in SCD1 cells, increasing RNA decay via the m6A reader YTHDC2. The SCD1 inhibitor A939572 inhibited growth and slowed down lipid metabolism in PTC cells. These results confirm the crucial role of METTL16 in restraining PTC progression through SCD1-activated lipid metabolism in cooperation with YTHDC2. This suggests that the combination of METTL16 and anti-SCD1 blockade might constitute an effective therapy for PTC.
Utilizing pyrolysis cleavage products from softwood kraft lignin as a substitute for phenol in phenol-formaldehyde resins for modifying different wood species
Authors: Karthäuser Johannes , Biziks Vladimirs , Roggatz Daniel , Militz Holger 
Published: February 2024

AbstractPhenol-formaldehyde resins can be used for wood modification through an impregnation process and subsequent curing within the wood cell wall. Phenol is gained from non-renewable resources, and its substitution by renewable chemicals has been a research goal. A promising example for renewable phenol substituents are lignin-derived organic chemicals. Phenol-formaldehyde resins with such substitutions have been studied, however, knowledge of their application for wood modification is deficient. While there are attempts to modify pine and beech wood with this method, studies on other wood species are scarce. Considering the increasing use of different wood species in wood industry, determining the influence of the wood species on the modification quality is an important research goal. Therefore, in this study, vacuum-pressure impregnation of five wood species – Scots pine sapwood (Pinus sylvestris), Norway spruce (Picea abies), European beech (Fagus sylvatica), Silver birch (Betula pendula), and European aspen sapwood (Populus tremula) – with phenol-formaldehyde resins is described. Here, up to 45% of the phenol in the synthetic resin is substituted by vacuum low-temperature microwave-assisted pyrolysis cleavage products from commercial softwood kraft lignin. The solution uptake, weight% gain, leaching, and anti-swelling efficiency of the modified wood are analyzed and compared. The results indicate that up to 30% of the phenol can be substituted without significant decreases in the performance of the modification. The method gives comparable results for most of the wood species described herein, with exception of beech wood, for which the modification had a lower quality. The results could help to develop more environmentally friendly wood modification methods for several common European wood species.
Epidemiology of heart failure in diabetes: a disease in disguise
Authors: Hoek Anna G. , Dal Canto Elisa , Wenker Eva , Bindraban Navin , Handoko M. Louis , Elders Petra J. M. , Beulens Joline W. J. 
Published: February 2024

AbstractLeft ventricular diastolic dysfunction (LVDD) without symptoms, and heart failure (HF) with preserved ejection fraction (HFpEF) represent the most common phenotypes of HF in individuals with type 2 diabetes mellitus, and are more common than HF with reduced ejection fraction (HFrEF), HF with mildly reduced ejection fraction (HFmrEF) and left ventricular systolic dysfunction (LVSD) in these individuals. However, diagnostic criteria for HF have changed over the years, resulting in heterogeneity in the prevalence/incidence rates reported in different studies. We aimed to give an overview of the diagnosis and epidemiology of HF in type 2 diabetes, using both a narrative and systematic review approach; we focus narratively on diagnosing (using the 2021 European Society of Cardiology [ESC] guidelines) and screening for HF in type 2 diabetes. We performed an updated (2016–October 2022) systematic review and meta-analysis of studies reporting the prevalence and incidence of HF subtypes in adults ≥18 years with type 2 diabetes, using echocardiographic data. Embase and MEDLINE databases were searched and data were assessed using random-effects meta-analyses, with findings presented as forest plots. From the 5015 studies found, 209 were screened using the full-text article. In total, 57 studies were included, together with 29 studies that were identified in a prior meta-analysis; these studies reported on the prevalence of LVSD (n=25 studies, 24,460 individuals), LVDD (n=65 studies, 25,729 individuals), HFrEF (n=4 studies, 4090 individuals), HFmrEF (n=2 studies, 2442 individuals) and/or HFpEF (n=8 studies, 5292 individuals), and on HF incidence (n=7 studies, 17,935 individuals). Using Hoy et al’s risk-of-bias tool, we found that the studies included generally had a high risk of bias. They showed a prevalence of 43% (95% CI 37%, 50%) for LVDD, 17% (95% CI 7%, 35%) for HFpEF, 6% (95% CI 3%, 10%) for LVSD, 7% (95% CI 3%, 15%) for HFrEF, and 12% (95% CI 7%, 22%) for HFmrEF. For LVDD, grade I was found to be most prevalent. Additionally, we reported a higher incidence rate of HFpEF (7% [95% CI 4%, 11%]) than HFrEF 4% [95% CI 3%, 7%]). The evidence is limited by the heterogeneity of the diagnostic criteria over the years. The systematic section of this review provides new insights on the prevalence/incidence of HF in type 2 diabetes, unveiling a large pre-clinical target group with LVDD/HFpEF in which disease progression could be halted by early recognition and treatment.Registration PROSPERO ID CRD42022368035.
Graphical Abstract
Stochastic comparisons, differential entropy and varentropy for distributions induced by probability density functions
Authors: Crescenzo Antonio Di , Paolillo Luca , Suárez-Llorens Alfonso 
Published: February 2024

Abstract
Stimulated by the need of describing useful notions related to information measures, we introduce the ‘pdf-related distributions’. These are defined in terms of transformation of absolutely continuous random variables through their own probability density functions. We investigate their main characteristics, with reference to the general form of the distribution, the quantiles, and some related notions of reliability theory. This allows us to obtain a characterization of the pdf-related distribution being uniform for distributions of exponential and Laplace type as well. We also face the problem of stochastic comparing the pdf-related distributions by resorting to suitable stochastic orders. Finally, the given results are used to analyse properties and to compare some useful information measures, such as the differential entropy and the varentropy.
Weighted product of point clouds and simplicial complexes
Authors: Babu Archana , John Sunil Jacob , Thankachan Baiju 
Published: February 2024

AbstractThis paper extends the concept of weighted point clouds and weighted simplicial complexes by introducing product point clouds and product simplicial complexes within a commutative ring with unity. Within an integral domain, the introduction of a weighted product chain group, along with the induced product weighted homomorphism and weighted product boundary maps, leads to significant outcomes and findings. To explore the algebraic characteristics of a weighted product structure, we introduce the concept of weighted product homology. This homology considers the relationship of weights assigned to elements within the structure and their impact on the structure’s underlying algebraic properties.
Optimal design and analyzing the techno-economic-environmental viability for different configurations of an autonomous hybrid power system
Authors: Abdelsattar Montaser , Mesalam Abdelgayed , Fawzi Abdelrahman , Hamdan I. 
Published: February 2024

AbstractIn the present day, there is widespread acceptance of autonomous hybrid power systems (AHPSs) that rely on renewable energy sources (RESs), owing to their minimal adverse effects on the environment. This paper evaluates and compares three various AHPS configurations comprising photovoltaic (PV) modules, wind turbines (WTs), batteries, and diesel generators (DGs), using a recent optimization approach. A new optimizer 'Dandelion-Optimizer' (DO) is applied to tackle design problems. Real-time meteorological data from Siwa Oasis in northwest Egypt was utilized to determine an optimum design of system components for the purpose of providing sustainable power to this remote region. The system configurations are effectively modelled and optimized to achieve the minimum cost of energy (COE), while also minimizing the loss of power supply probability (LPSP) and carbon dioxide (CO2) emissions. As per the results, the last configuration (PV with both backup equipment) is the most optimal one in terms of the lowest cost, whereas the first configuration (PV and WT with both types of backup equipment) is the most optimal one with regards to the lowest carbon emissions.
Forensic profiling of smokeless powders (SLPs) by gas chromatography–mass spectrometry (GC-MS): a systematic investigation into injector conditions and their effect on the characterisation of samples
Authors: Kesic Blake , McCann Niamh , Bowerbank Samantha L. , Standley Troy , Liechti Jana , Dean John R. , Gallidabino Matteo D. 
Published: February 2024

AbstractSmokeless powders (SLPs) are composed of a combination of thermolabile and non-thermolabile compounds. When analysed by GC-MS, injection conditions may therefore play a fundamental role on the characterisation of forensic samples. However, no systematic investigations have ever been carried out. This casts doubt on the optimal conditions that should be adopted in advanced profiling applications (e.g. class attribution and source association), especially when a traditional split/splitless (S/SL) injector is used. Herein, a study is reported that specifically focused on the evaluation of the liner type (Ltype) and inlet temperature (Tinj). Results showed that both could affect the exhaustiveness and repeatability of the observed chemical profiles, with Ltype being particularly sensitive despite typically not being clarified in published works. Perhaps as expected, degradation effects were observed for the most thermolabile compounds (e.g. nitroglycerin) at conditions maximising the heat transfer rates (Ltype = packed and Tinj ≥ 200 °C). However, these did not seem to be as influential as, perhaps, suggested in previous studies. Indeed, the harshest injection conditions in terms of heat transfer rate (Ltype = packed and Tinj = 260 °C) were found to lead to better performances (including better overall %RSDs and LODs) compared to the mildest ones. This suggested that implementing conditions minimising heat-induced breakdowns during injection was not necessarily a good strategy for comparison purposes. The reported findings represent a concrete step forward in the field, providing a robust body of data for the development of the next generation of SLP profiling methods.
Graphical abstract
Charakterisierung der Vorhofflimmerlast mittels Wearables
Authors: Betz Konstanze , Linz Dominik , Duncker David , Hillmann Henrike A. K. 
Published: February 2024

ZusammenfassungDie Charakterisierung von Vorhofflimmern (VHF) entsprechend der aktuellen Leitlinien bezieht sich kategorisch auf die Differenzierung zwischen paroxysmalem, persistierendem und permanentem VHF. Eine genauere Charakterisierung, auch mithilfe einer Evaluation der Vorhofflimmerlast, spielt sowohl in der Wissenschaft als auch im klinischen Alltag eine zunehmende Rolle. Wearables, insbesondere mit der Möglichkeit einer passiven (semi-)kontinuierlichen Aufzeichnung, können hier zur genaueren Quantifizierung beitragen. Primär bei Patient:innen mit bereits etablierter Vorhofflimmerdiagnose kann die Evaluation der Vorhofflimmerlast beispielsweise zur Erfolgskontrolle einer antiarrhythmischen Therapie, sei es medikamentös oder interventionell, eingesetzt werden. Offen bleiben jedoch noch wichtige Fragestellungen: Neben einer einheitlichen, evidenzbasierten Definition der Vorhofflimmerlast müssen auch klinisch relevante Cut-off-Werte sowie daraus resultierende therapeutische Konsequenzen (z. B. eines subklinischen Vorhofflimmerns) erarbeitet werden. Zudem sollte eine Etablierung und Evaluation von Versorgungsstrukturen zur Auswertung und klinischen Anwendung der Vorhofflimmerlast, insbesondere unter Einbezug von mittels Wearables erhobenen Daten, stattfinden.
The influence of MRI-based pelvimetric measurements in mother’s choice of delivery in fetal breech position
Authors: Ebeling Anna Elisabeth , Maschke Sabine Katharina , Holthausen-Markou Sophia , Steinkasserer Lena , Klapdor Rüdiger , Renz Diane , Meier Nina , von Kaisenberg Constantin , Hillemanns Peter , Brodowski Lars 
Published: February 2024

Abstract
Introduction
At term, about 3–4% of all singleton pregnancies present as breech. MRI-based pelvimetry is a valuable tool to support selection of adequate candidates for a trial-of-labor in women expecting term breech babies. Shared decision-making is playing an increasingly important role in obstetrics. Since the divergent existing knowledge of breech term delivery needs to be discussed with the pregnant woman, we examined the influence of MRI results on the shared decision-making process in women with term breech presentation.

Methods
Between 08/2021 and 12/2022, anamnestic and clinical parameters were collected from singleton pregnancies expecting term breech babies resulting in birth at the Hanover Medical School. After information, written consent and inclusion, clinical parameters, the course of birth and the maternal and fetal outcome were collected retrospectively. 32 women participated in a postpartum questionnaire study on inquiry. The subsequent acquisition of information and the arguments in the decision-making process were determined. In addition, the sense of security and self-determination was asked both before and during birth.

Results
50% of the respondents had not decided for a mode of delivery before having MRI pelvimetry. After imaging and information, about the own pelvic dimensions and predictors for a successful vaginal birth, 80% of this subgroup decided to give birth vaginally. Over 40% of the collective descripted that they made a decision based on the result of MRI pelvimetry. None of the women felt to be insecure after having talked about the MRI results. The elective cesarean section group and the group of those who delivered vaginally were approximately equally highly satisfied with their feeling of self-determination of the birth mode. Overall, the study population had a very positive birth experience. The group of women who had delivered by elective cesarean showed a wider range in their assessment and appeared to perceive the experience more negative than the group of women who had a vaginal birth or emergency cesarean. Fetal and maternal outcomes did not differ between the groups.

Discussion
MRT pelvimetry measurements can be used as a predictor for a successful vaginal breech delivery. The additional information obtained from the MRI measurements can be used in the shared decision-making process to decide more easily on the mode of delivery while improving women's awareness and safety. A balanced education on rare and frequently adverse events of vaginal delivery and cesarean section and patient expectations about labor processes must be taken into account.
Small cell osteosarcoma versus fusion-driven round cell sarcomas of bone: retrospective clinical, radiological, pathological, and (epi)genetic comparison with clinical implications
Authors: Hiemcke-Jiwa Laura S. , Sumathi Vaiyapuri P. , Baumhoer Daniel , Smetsers Stephanie E. , Haveman Lianne M. , van Noesel Max M. , van Langevelde Kirsten , Cleven Arjen H. G. , van de Sande Michiel A. J. , ter Horst Simone A. J. , Kester Lennart A. , Flucke Uta 
Published: February 2024

AbstractSmall cell osteosarcoma (SCOS), a variant of conventional high-grade osteosarcoma (COS), may mimic fusion-driven round cell sarcomas (FDRCS) by overlapping clinico-radiological and histomorphological/immunohistochemical characteristics, hampering accurate diagnosis and consequently proper therapy. We retrospectively analyzed decalcified formalin-fixed paraffin-embedded (FFPE) samples of 18 bone tumors primarily diagnosed as SCOS by methylation profiling, fusion gene analysis, and immunohistochemistry.In eight cases, the diagnosis of SCOS was maintained, and in 10 cases it was changed into FDRCS, including three Ewing sarcomas (EWSR1::FLI1 in two cases and no identified fusion gene in the third case), two sarcomas with BCOR alterations (KMT2D::BCOR, CCNB3::BCOR, respectively), three mesenchymal chondrosarcomas (HEY1::NCOA2 in two cases and one case with insufficient RNA quality), and two sclerosing epithelioid fibrosarcomas (FUS::CREBL3 and EWSR1 rearrangement, respectively).Histologically, SCOS usually possessed more pleomorphic cells in contrast to the FDRCS showing mainly monomorphic cellular features. However, osteoid was seen in the latter tumors as well, often associated with slight pleomorphism. Also, the immunohistochemical profile (CD99, SATB2, and BCOR) overlapped.Clinically and radiologically, similarities between SCOS and FDRCS were observed, with by imaging only minimal presence or lack of (mineralized) osteoid in most of the SCOSs.In conclusion, discrimination of SCOS, epigenetically related to COS, versus FDRCS of bone can be challenging but is important due to different biology and therefore therapeutic strategies. Methylation profiling is a reliable and robust diagnostic test especially on decalcified FFPE material. Subsequent fusion gene analysis and/or use of specific immunohistochemical surrogate markers can be used to substantiate the diagnosis.