bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial and Temporal Heterogeneity in Clonal Evolution of Nonsmall-cell Lung Cancer: Implications for Therapy
Authors: Koulouris A. , Tsagkaris C. , Mountzios G. 
Published: October 2023

Abstract

Introduction
Tumoral heterogeneity has been associated with treatment resistance and failure in patients with cancer. Tumoral heterogeneity can be either intertumoral (static variation of cancer cells) or intratumoral (spatial and temporal variation of cancer cells). Nonsmall-cell lung cancer (NSCLC) is considered a model disease for the study of tumoral heterogeneity, given the emerging evidence about the clinical implications of genetic variations among NSCLC subtypes. This review provides an overview of the etiology, detection, and management methods of intratumoral heterogeneity in NSCLC and discusses their clinical implications.

Methods
The authors searched biomedical databases (Medline, Scopus, Embase) for studies reporting on intratumoral heterogeneity in NSCLC.

Results
Intratumoral heterogeneity occurs in single tumors, multiple tumors in the same organs, primary tumors and metastases, and among distinct metastases. Genetic (selective pressure, clonal evolution, genomic instability) and nongenetic pathways (tumor metabolism, hypoxia) precipitate heterogeneity across the spatial and temporal progression of the disease. Proposed classifications are based either on cancer subtypes or mutations detected and metastasis sites. Liquid biopsies (cell-free DNA, circulating tumor cells) combined with imaging (computed tomographies (CTs), positron emission tomography/computed tomographies (PET/CTs)) have a major potential for the continuous minimally invasive monitoring of intratumoral heterogeneity in comparison to conventional biopsies. Targeted therapies have a higher likelihood to induce heterogeneity and resistance, while PD-L1 immunotherapy represents a promising therapeutic strategy.

Conclusion
Spatial and temporal intratumoral heterogeneity within a single patient sets additional challenges to personalized precision medicine, calling for continuous cellular and molecular-level surveillance and adequate adjustment of the treatment plan.
Intercultural Communication: Hampering and Facilitating Factors in International Business
Authors: Devjak Ingrid , Sabidussi Anna , Bezcioğlu-Göktolga Irem , Smeets Reinier 
Published: October 2023

Abstract

Objective
This paper aims at uncovering the hampering and facilitating factors in intercultural communication that professionals encounter in their business relationships.

Methodology
The data collection process involved conducting individual interviews and two rounds of focus groups with professionals who shared their experiences in working with another culture. The transcripts were analyzed using Thematic Analysis (Braun & Clarke, 2012) with the assistance of Atlas.ti 9.

Findings
The key challenges that emerged were differences in communication styles: too direct versus too indirect; misunderstandings and misconceptions when communicating in non-native languages; differences in business customs, such as separating business from private life versus blurred business and personal relationships; differences in decision-making and stereotyping.

Value Added
We offer a new perspective about existing models and theories of intercultural dimensions, highlighting the risks they entail when superficially generalized. Our paper contributes to professional practice by illustrating how language, differences in the communication style, business etiquette and stereotyping can prevent successful interactions. We show that business English may facilitate international communication but may easily become a source of misinterpretation.

Recommendations
Intercultural flexibility can play a fundamental role in contextualizing communication and providing true meaning to businesses exchanges. Adjusting language, focusing on building trustful relationships and creating alignment processes can all be instrumental for more effective and successful business communication. Future research with business professionals from diverse cultural backgrounds would enrich our understanding of intercultural business communication.
Theoretical investigations into the Spectrophotometrically Analyzed Niobium (V)-6-Chloro-3-hydroxy-7-methyl-2-(2’-thienyl)-4H-chromen-4-one Complex
Authors: Dhonchak Chetna , Agnihotri Nivedita , Azam Mohammad , Javed Saleem , Muthu Sambantham , Al-Resayes Saud I , Min Kim 
Published: October 2023

Abstract
Pentavalent niobium cation forms a stable yellow-colored binary complex with 6-chloro-3-hydroxy-7-methyl-2-(2’-thienyl)-4H-chromen-4-one (CHMTC) in the ratio of 1:2. The complex is quantitatively extractable into carbon tetrachloride from HClO4 solution maintained at pH 1.26–1.75 and strictly adheres to Beer’s law as verified by the Ringbom plot with an optimized range of determination as 0.385–1.211 ppm of Nb(V). The ligand-metal complex system shows good precision, accuracy, sensitivity, and selectivity and handles satisfactorily the analysis of several samples of varying complexity. The results are highly reproducible as confirmed by statistical data. The stability of the complex is theoretically confirmed with the help of HOMO-LUMO values and the energy gap [for CHMTC, ΔE
gap = 3.62 V and for Nb(V)-CHMTC Complex, ΔE
gap = 2.97 eV]. The reactivity descriptors were calculated for detailed computational study to probe into the chemical behavior of the studied ligand and its complex. Further, mapped electrostatic potential diagrams help in justifying the donor sites of CHMTC ligand which is in accordance with the analytical findings.
CFD-DEM simulation of raceway size and mechanical characteristics of industrial scale blast furnace
Authors: Gao Yuzhen , Chan Choon Kit 
Published: October 2023

Abstract
The raceway plays a crucial role in ensuring the stable functioning of the ironmaking blast furnace. It is the key site where the chemical reaction of coke combustion takes place, providing the necessary heat and reducing gas for the upper iron ore reduction process. Consequently, the size of the raceway serves as an essential indicator of the blast furnace’s operational condition. In this study, a mathematical model for the raceway of an industrial-scale blast furnace was established. Extensive innovation investigations were conducted to explore the characteristics pertaining to the raceway’s size. The simulation outcomes demonstrate that both the particle size and the inlet velocity exert significant influences on the raceway dimensions. Specifically, the height of the raceway is predominantly affected by the particle size, whereas the inlet velocity predominantly influences the depth of the raceway.
Reverse Engineering-Inspired Parametric 3D Geometry Model of Marine Propeller
Authors: Zheng Long , Chen Shunhuai , Chen Xinyu , Ji Shengchen 
Published: October 2023

Abstract
In this study, an effective parametric 3D geometry model of a propeller was established with the aid of reverse engineering. The goal is to reduce the free parameters while automating the modelling of the propeller. The process of building the parametric model begins by generating an initial point cloud by defining the feature matrix associated with the propeller blade profile shape. Subsequently, the initial point cloud is deformed and refined by the deformation feature matrix and resampling. Finally, a 3D geometry model of the propeller is generated by surface reconstruction. The model can be built automatically by interactively modifying the feature matrices. Two numerical analyses illustrate the performance of the parametric 3D geometry model. Specifically, two propellers are constructed using the proposed model to estimate the shape error between the reconstructed propellers and the original offset of the propellers. These propellers are selected as research objects to determine the hydrodynamic performance error between the propeller constructed by the proposed model and a benchmark propeller. According to the results of the numerical study, the parametric 3D geometry model can precisely reconstruct the aforementioned geometry within a valid error range. The hydrodynamic error analysis demonstrates that the geometric inaccuracy from the reconstructed model has less impact on the propeller performance. This indicates that the model described in this study is generalised and robust. Moreover, some uncommon propeller CAD models were generated in batches using the parametric 3D geometry model.
Fault Diagnosis of Bearings Based on SSWT, Bayes Optimisation and CNN
Authors: Yan Guohua , Hu Yihuai , Shi Qingguo 
Published: October 2023

Abstract
Bearings are important components of rotating machinery and transmission systems, and are often damaged by wear, overload and shocks. Due to the low resolution of traditional time-frequency analysis for the diagnosis of bearing faults, a synchrosqueezed wavelet transform (SSWT) is proposed to improve the resolution. An improved convolutional neural network fault diagnosis model is proposed in this paper, and a Bayesian optimisation method is applied to automatically adjust the structure and hyperparameters of the model to improve the accuracy of bearing fault diagnosis. Experimental results from the accelerated life testing of bearings show that the proposed method is able to accurately identify various types of bearing fault and the different status of these faults under complex running conditions, while achieving very good generalisation ability.
Experimental Study of the Nonlinear Behaviour of Deep-Sea Mooring Polyester Fibre Ropes
Authors: Zhang He , Zeng Ji , Jin Bowen , Chou Chiate , Li Hangyu , Dong Hailei 
Published: October 2023

Abstract
Mooring ropes are essential components of ships and offshore floating structures and they are subjected to cyclic axial loads. This study investigates the evolution of the full-cycle stiffness of fibre polyester ropes under long-term static and dynamic loading. First, the static stiffness characteristics of the ropes, including the rope elongation properties at different stages, shrinkage rates, and creep coefficients after an idle period, are examined under static loads; an empirical formula for static stiffness is established. Second, the dynamic stiffness characteristics of the ropes are investigated under cyclic loads that are typical of platform production operations. The stabilities of the structure under different tensions are compared; the effects of mean tension, tension amplitude, and load cycle on the dynamic stiffness of the ropes are analysed and an empirical formula is established to predict the dynamic stiffness during the engineering design phase. The results of this study can be helpful for the rational design of deep-sea taut-leg mooring systems because they present the evolution of the full-cycle stiffness characteristics of mooring ropes.
Digitalization and smartening public governance of the European high north regions
Authors: DE MELO CARTAXO Tiago , HOSSAIN Kamrul 
Published: October 2023

Balancing technological evolution, protection of the environment and social communities well-being has never been a simple task. However, while everything changes at an incredible fast-pace, public authorities, private entities and even civil society must accompany that movement. It is, therefore, crucial that primarily public officials and legislators build their activities on solid information, especially in places where a harsh climatic condition, sparse population distribution and longer distances make public involvement more difficult. The European high north is an example of a region where the recent phenomena of big data, certainly represents challenges because of its yet to fully developed infrastructure, but also opportunities for improving, peopleâ€™s lives, and enhancing sustainable development, through smart mechanisms. In fact, digitalisation and new technologies can cause negative and/or positive consequences in the life of certain communities, depending on the means and purposes they are used for. This article intends to demonstrate how an adaptive, in other words smart governance approach (digitalized governance approach) â€“ based on open, flexible and participatory tools â€“ could improve the life of human beings in the territories of the European High North (EHN), preparing the region and its inhabitants for the challenges of sustainable development.
The role of smart cities to promote smart governance in municipalities
Authors: LANGA Vuyani Goodman , THAKHATHI Reckson Dovhani 
Published: October 2023

The main focus of this paper is to provide a contextualized reflection about what smart cities are and their primary contribution in promoting smart governance.
Objectives
Objectives include amongst others, the definition of the smart city concept and how it can be used as a means to achieve more efficient and sustainable cities. It further elucidates the use of internet enhanced public service delivery to promote smart governance in municipalities.
Prior Work
This paper is built upon existing prior work that has been done in the emerging trends in smart cities. Researchers have identified several different “discourses” related to smart cities However, this paper delves deeper into how innovation and the concept of internet of things can enhance public service delivery. It further contextualizes the use of internet enabled public services with the purpose of making municipalities smart cities, with smart governance by offering smart services to its communities.
Approach
A qualitative research approach was used to fulfil the objectives of the paper through an in-depth desktop analysis of existing literature from recent journals.
Results
The research findings traverse that although a plethora of challenges remain, it is the amenability of both the political and administrative leadership and the gravity attached to technology that determines the extent of depth of transforming municipalities towards the goal of being smart cities.
Implications
The overall goal of this paper is to lay a foundation for the development of a comprehensive framework to redirect administrators and political office bearers towards smart city and smart governance inclined policy directives as suggested in the research findings. Inferences drawn from the paper will assist in further research in the field of innovation, smart cities and smart governance as wheels and machinery of service delivery.
Value
Finally, this paper attempts to merge theory and practice to work towards understanding of what a smart city means for South African cities through smart governance manage and minimize challenges confronted by municipalities through the use of technology.
Prediksi Toksisitas In Silico Senyawa Bioaktif Daun Kemangi (Ocimum sanctum. L)
Authors: Wangsasaputra Ester , Prihandini Satria , Ginting Chrismis Novalinda , Chiuman Linda 
Published: October 2023

Pendahuluan: Ocimum sanctum L. (daun kemangi) banyak ditemukan dan sering digunakan sebagai bahan makanan di Indonesia. Senyawa flavonoid merupakan kelompok senyawa kimia yang banyak terkandung dalam Ocimum sanctum L. Senyawa ini dikenal dengan aktivitas biologisnya yang beragam, antara lain antibakteri, antimikroba, antiinflamasi, antimalaria, dan antikanker. Pada penelitian ini, kami bertujuan untuk menyelidiki penyerapan, distribusi, metabolisme, ekskresi, dan toksisitas (the absorption, distribution, metabolism, excretion, and toxicity/ADMET) senyawa flavonoid dalam Ocimum sanctum L.
Metode: Dalam mencapai tujuan penelitian, prediksi properti ADMET senyawa flavonoid pada Ocimum sanctum L. dilakukan menggunakan tiga web server yang terdiri dari SwissADME, pkCSM, dan ProTox-II. Parameter yang diamati dibagi menjadi parameter ADMET.
Hasil: Hasil penelitian menunjukkan bahwa senyawa flavonoid dalam Ocimum sanctum L. memiliki median lethal dose (LD50) yang berkisar antara 2000 mg/kg hingga 5600 mg/kg, dengan klasifikasi kelas toksisitas IV, V, dan VI. Selain itu, senyawa flavonoid ini menunjukkan imunotoksisitas, sitotoksisitas, dan dampak pada Mitochondrial Membrane Potential (MMP).
Kesimpulan: Penelitian kami menunjukkan bahwa senyawa metabolik yang berasal dari Ocimum sanctum L. dianggap aman.
Estimation of the reference value of pubofemoral distance in normal infants by ultrasonography: A pilot study in Indian population
Authors: Chawla Siddhi , Meena Gaurav 
Published: October 2023

Objectives:
The objectives of this study were to determine the normal values of pubofemoral distance (PFD) and its variation with age, sex, and laterality of hip in infants in the Indian population.

Material and Methods:
The PFD was measured in 141 infants falling under Grafs categories I, IIa, and IIb (Males: 77 and Females: 64) divided into two groups comprising the neonatal group (<1 month) and postneonatal group (>1–12 months). PFD measurement and Grafs’ method of alpha- and beta-angle measurement were both performed at the same time by doing an ultrasound of the hip. Probe was placed in the coronal plane in lateral decubitus with the flexed position in a neutral position. PFD was measured between the superior pubic rami and femoral head epiphyses.

Results:
The average PFD in 141 infants (282 hips) was 3.23 ± 0.83 mm. It was 3.15 ± 0.79 mm in the neonatal group (88 patients) and 3.47 ± 0.84 mm in the postneonatal group (53 patients). In males, the average PFD was 3.29 ± 0.85 mm, and in females, it was 3.23 ± 0.81 mm. No significant difference was observed in the average PFD among the two sexes and between the left and right hips of both neonatal and postneonatal groups.

Conclusion:
The study demonstrates reference PFD values in infants aged 0–12 months in neonatal and postneonatal age groups. Mean PFD values were not significantly influenced by the laterality or sex of the patient in both groups, however, increased with age. Further studies need to be done however to find its values in the cases with developmental dysplasia of the hip to determine the cutoff in such cases.
USE OF DAILY COMMUNICATION STRATEGIES FOR BASIC-LEVEL JAPANESE LEARNERS
Authors: Mael Masilva Raynox , Kitano Hiroaki 
Published: October 2023

Communication strategy is very important in interacting and conversing in a foreign language with native speakers. This research discusses the communication strategies used by a beginner Japanese learner from Indonesia who directly lives in Japan to communicate with Japanese people in everyday life. The data was taken from recording conversations with native Japanese speakers for 3 months in daily conversations. The result is that by using these communication strategies, a Japanese language learner can carry out daily activities by minimizing misunderstandings. The use of fillers or aizuchi is the most used strategy in conversations with Japanese people.
Keywords: Communication strategy, Japanese, basic level
Palyatif Bakım Merkezleri İç ve Dış Mekanlarında Doğa ile Tasarım
Authors: CETİN Cigdem , ÇETİNKAYA KARAFAKI Filiz 
Published: October 2023

Palyatif bakım, terminal dönem hastaların, kalan hayatlarını daha az sıkıntılı ve daha konforlu geçirmeleri için özelleşmiş bakım şeklidir. Sağlık hizmeti veren yapılarda ya da evde bakımda hastanın ihtiyacı olacak bakım şartlarının uygulanması için özel tasarlanmış mekanlara ihtiyaç vardır. Palyatif bakım, hastanın hastalık sürecinde değişen insani gereksinimlerini ve yakınlarının ihtiyaçlarını karşılamak üzere multidisipliner olarak hazırlanmış bütüncül bir sağlık planı içermelidir. Bu doğrultuda, çalışma kapsamında doğa ile birlikte tasarlanmış iç ve dış mekanların hastalar ve yakınları üzerinde olumlu etkileri olabileceği hipotezi ortaya konmuştur. Çalışma aynı zamanda palyatif bakım merkezlerinde doğa ile bütünleşmiş mekân tasarımlarının palyatif bakım altında olan hastalar ve hasta yakınları üstündeki çoklu etkilerini ortaya koymayı hedeflemiştir.
Literatürde bu bağlamda kabul görmüş üç ayrı araştırmacının birbiri ile ilişkili teorileri; ‘Psiko-evrimsel Teori’, Stresi Yenme Teorisi ve Dikkat Yenileme Teorisi dikkate alınarak mekânsal öneriler sunulmuştur. Yapılan araştırma sonucunda elde edilen veriler ışığında, palyatif bakım merkezlerindeki iç mekân- dış mekân birlikteliğinin doğa elemanlarının olumlu etkileri bağlamında süreklilik içinde tasarlanması gerekliliği ortaya çıkmıştır. Tasarlanan mekanların sadece niceliksel değil, kapsam ve bireylerin gereksinimlerine uyumluluk açısından değerlendirilmesinin palyatif bakımda olumlu etkiler yaratacağı vurgulanmıştır.
Modeling of the selective laser melting process in additive manufacturing
Authors: Grigoryants Aleksandr 
Published: October 2023

The possibilities of theoretical analysis based on numerical modeling of complex processes of additive manufacturing by selective laser melting method are viewed. Methods of high-precision modeling of the formation of a single melt bath are discussed, taking into account the geometry of the formed powder layer, the energy distribution in the spot, the effects of ray re-reflection, the vapor recoil force, the Marangoni effect and denudation mechanisms. Experimental studies on the cultivation of samples from BrX copper powder with particles of 20...50 microns in size by selective laser melting using continuous fiber laser radiation with a wavelength of 1.064 microns were carried out. In particular, all the experiments were carried out under conditions when growing conditions and modes are completely coincident with the calculated model. To assess the accuracy of the modeling system, the dimensions of the melting region and the morphology of the surface of the melt were compared. The presented computational model was used in the development of technology for growing products from copper alloy powders using selective laser melting method. Research in the field of modeling the stress-strain state in a composite material formed in the SLP process, consisting of an Ak9ch alloy matrix reinforced with titanium carbide particles, is also presented. Calculations were performed to identify the influence of shape (sphere, icosahedron, prism), size (1,0 microns; 5,0 microns; 10 microns) and mass concentration
(1,0 %; 3,0 %; 5,0 %; 7,0 %; 10 %; 15 %), taking into account the presence of pores of various shapes. The results of calculations are compared with the results of experiments. Numerical models with subsequent experimental approbation of the optimal variant make it possible to significantly reduce the time spent for the development of new complex and promising additive technologies.
Nursing Student Perceptions About The Role Of The Tutor And Implementation Of The Tutorial Process Using The Seven Jumps Technique
Authors: Syafrizal Syafrizal 
Published: October 2023

Seven jumps is an approach used in the problem solving learning method or Problem Based Learning (PBL). The seven jumps technique implemented using the tutorial method directed by a tutor. The tutor's role is one of the critical factors for the success of the tutorial process. Students' perceptions of the tutor's role will affect the pros and cons of implementing tutorials. Therefore, it is necessary to test the role of the tutor and implementation of the tutorial process. The purpose of this study was to find the perceptions of nursing students about the role of the tutor and implementation of the tutorial process using the seven jumps technique. This study used a descriptive design. The population in this study was students of the regular program of the Faculty of Nursing, University of Riau. The sample in this study amounted to 222 people who recruited using simple random sampling technique. The measuring instrument used is a questionnaire made by researchers using google from which has been test for validity and reliability. This study shows that for the tutor role there are 114 respondents (51.4%) who have positive perceptions and 108 respondents (48.6%) have negative perceptions. As for implementation of the tutorial process, there were 117 respondents (52.7%) who had positive perceptions and 105 respondents (47.3%) had negative perceptions. This research expected to test the learning process and optimize the tutor's role in implementing tutorials using the seven jumps technique. Keywords: Student Perceptions; Tutor; Seven Jump Technique