bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between attitudes toward oral health at initial office visit and compliance with supportive periodontal treatment
Authors: Ojima M. , Kanagawa H. , Nishida N. , Nagata H. , Hanioka T. , Shizukuishi S. 
Published: March 2005

AbstractObjectives: The objectives of the present study include investigation of the relationship between attitudes and desires with respect to oral health at initial office visit and compliance with supportive periodontal treatment (SPT) and identification of prognostic factors with respect to low‐compliance with SPT.Materials and Methods: Four hundred thirty‐one patients were evaluated. Subjects completed a questionnaire concerning attitude and desire with respect to oral health and subjective symptoms prior to periodontal treatment. Survival probabilities of SPT were estimated by the Kaplan–Meier method and compared between answers for each item of the questionnaire via the Cox–Mantel test. Finally, a multivariate Cox proportional hazards regression model was constructed, which included age and gender.Results: Greater than 95% of participants desired toothbrushing proficiency and lifelong retention of teeth at the initial office visit; however, the overall survival probabilities of SPT were only 52.7% after about 5 years. Patients exhibiting unfavourable attitudes toward oral health at the initial office visit, in comparison with those displaying favourable attitudes, exhibited greater tendency to abandon SPT. A Cox regression model revealed that lack of brushing on the gingival margin, non‐use of an inter‐dental brush or dental floss, non‐use of fluoride toothpaste and frequent consumption of sugar‐containing drinks were significant independent prognostic factors for low‐compliance with SPT (p<0.05; Hazard ratios=2.27, 2.00, 2.56 and 2.06, respectively).Conclusions: Desire for satisfactory oral health is not related consistently to continuation of SPT. Unfavourable attitudes toward oral health were correlated to low‐compliance with SPT. Clinicians may wish to establish methods for improvement of patient compliance employing behavioural approaches applicable to the attitudes of potential low‐compliance individuals.
A 0.05% cetyl pyridinium chloride/0.05% chlorhexidine mouth rinse during maintenance phase after initial periodontal therapy
Authors: Quirynen Marc , Soers Catherine , Desnyder Mandy , Dekeyser Christel , Pauwels Martine , Van Steenberghe Daniel 
Published: March 2005

AbstractBackground: Chlorhexidine (CHX) mouth rinse/spray can still be considered the gold standard in the chemical prevention of plaque formation and development of gingivitis. The product unfortunately has some side effects, such as extrinsic tooth staining, poor taste, taste disturbance, sensitivity changes in tongue, pain and irritation because of the alcohol content. These side effects led to the search of new formulations.Methods: In this double‐blind, randomized, long‐term, parallel study, 48 moderate periodontitis patients rinsed for 6 months (starting immediately after a “one‐stage, full‐mouth” disinfection) with one of the following products: CHX 0.2%+alcohol (Corsodyl®), CHX 0.05%+ cetyl pyridinium chloride (CPC) 0.05% and no alcohol (Perio‐Aid Maintenance®, a new formulation), or the placebo of the latter. After 1, 3 and 6 months a series of clinical and microbiological parameters were recorded for the supra‐ and subgingival area as well as for saliva.Results: Although there was a significant treatment impact (mechanical debridement) in all groups, both CHX solutions further decreased both plaque and gingivitis indices (p<0.001 and p<0.05, respectively), when compared with placebo. This was also reflected by additional reductions in the number of CFU/ml of aerobic and especially anaerobic species and by a suppression of Streptococcus mutans (versus an overgrowth for the placebo), in all niches. Differences between both CHX solutions were never encountered. The subjective ratings were slightly in favour of the new CHX–CPC formulation when compared with the other CHX–alcohol formulation, especially for taste of the product (p<0.05), but less impressive for the staining of teeth and tongue.Conclusions: The results of this study demonstrated the potential of a new CHX 0.05%+CPC 0.05% non‐alcoholic formulation as an effective antiplaque agent for long‐term use with reduced subjective side effects.
Gingivo‐mucosal and cutaneous reactions to amalgam fillings
Authors: Fardal Øystein , Johannessen Anne C. , Morken Tore 
Published: March 2005

AbstractBackground:A number of reports exist on the side effects of materials used to restore teeth. Most of the cases involve local allergy reactions, but also skin lesions are described. Few cases are described where both local effects on the mucosa and skin lesions distant to the oral cavity are caused by amalgam.Result:The case presented indicates that the release of mercury from amalgam fillings is able to induce hypersensitivity reactions resulting in soft‐tissue changes in the gingiva, buccal mucosa, tongue and on the skin of the back of the hands.
Interest in periodontology and preferences for treatment of localized gingival recessions
Authors: Zaher C.‐A. , Hachem J. , Puhan M. A. , Mombelli A. 
Published: March 2005

AbstractObjectives: The purpose of this study was to evaluate the views, knowledge and preferences of a large sample of practising dentists in periodontics, focusing specifically on the treatment of gingival recessions, and to compare the findings with the current evidence available in the dental literature.Methods: We conducted a cross‐sectional postal survey of 3780 dentists, representing the majority of all dentists working in Switzerland. The questionnaire consisted of 17 questions, most of them giving the possibility of multiple choices of answers. The demographic profile, interests and satisfaction in periodontics were associated with the choice of treatment options offered for the management of six clinical situations.Results: One thousand two hundred and one dentists sent back the questionnaire within three months and were thus included in the analysis. In general, the interest and the satisfaction in periodontics were moderate to high (6–7 on an analogue scale from 1 to 10). Specialists in periodontics indicated a significantly higher interest and satisfaction in periodontics than the general dentists (p<0.001), and practitioners working in urban areas indicated a slightly higher interest (p=0.027) and satisfaction (0.047) than their colleagues established in a rural setting. The predominant indication of root coverage procedures was aesthetics (90.7%). The region in which dentists worked was the only significant predictor for choosing “no treatment” of buccal recessions: dentists from the German‐speaking part were significantly less inclined to surgically treat gingival recessions than their colleagues from the French or Italian part. For those who opted for therapy, a free tissue graft was generally the favourite option, followed by a connective tissue graft and a coronally advanced flap. Throughout, only a small fraction of the dentists considered using a guided tissue regeneration procedure. The relative odds for not extracting teeth with severe periodontal disease were higher if the dentist was a specialist than a generalist. Satisfaction in practicing periodontics also positively strengthened the inclination towards keeping severely compromised teeth.Conclusions: Aesthetic concerns were the predominant indication for root coverage procedures. Further research should therefore include aesthetic aspects as primary clinical outcome variables. Specific training of dentists and their satisfaction in periodontics influenced treatment decisions. Specialists involved in continuing education should inform practicing dentists more efficiently on the potential and usefulness of periodontal therapy for saving and maintaining periodontally compromised teeth.
A new ultrasonic device in maintenance therapy: perception of pain and clinical efficacy
Authors: Kocher Thomas , Fanghänel Jutta , Schwahn Christian , Rühling Andreas 
Published: March 2005

AbstractBackground: A recently introduced piezo‐driven ultrasonic device (Vector®) generates longitudinal oscillations. As a result, the instrument tip moves parallel to the tooth surface. By avoiding vertical oscillations, maintenance treatment with the Vector® device should be less painful than treatment with conventional systems. We investigated whether patients perceive treatment with the Vector® device as less painful than with a conventional ultrasonic device, and whether the clinical efficacy of the Vector® device is comparable with that of the conventional ultrasonic device in maintenance patients.Material and methods: Thirty‐eight maintenance patients with moderate to advanced periodontal disease took part in this prospective, randomized controlled clinical study. Each patients had to have at least two teeth with probing depths of >4 mm. They were treated either with Dentsply® (n=22) at a reduced power setting or with the Vector® device (n=16). The observation period was 6 months. Probing pocket depth, attachment level, and bleeding upon probing were assessed at six sites on each treated tooth by a blinded investigator Patient were asked to report perceived pain during instrumentation with a visual analog scale immediately after treatment, in the evening of the treatment day, and in the evenings 1 and 2 days after treatment.Results: Bleeding on probing, probing depth, and attachment level improved in both instrumentation groups from baseline to month 6; however, there was no difference between the two instrumentation modalities. The patients perceived treatment with neither instrument as unpleasant, and their perception of pain intensity both during instrumentation and on the following days did not differ.Conclusion: In maintenance therapy, clinical efficacy of the vector® device is comparable with that of conventional ultrasonic device. It makes no difference whether the ultrasonic device at a reduced power setting or the Vector® device is used, since patients perceive both instruments as causing very little pain.
ON THE ASYMPTOTIC ANALYSIS OF THE DIRAC–MAXWELL SYSTEM IN THE NONRELATIVISTIC LIMIT
Authors: BECHOUCHE PHILIPPE , MAUSER NORBERT J. , SELBERG SIGMUND 
Published: March 2005

We study the behavior of solutions of the Dirac–Maxwell system (DM) in the nonrelativistic limit c → ∞, where c is the speed of light. DM is a nonlinear system of PDEs obtained by coupling the Dirac equation for a 4-spinor to the Maxwell equations for the self-consistent field created by the moving charge of the spinor. The limit c → ∞, sometimes also called post-Newtonian, yields a Schrödinger–Poisson system, where the spin and magnetic field no longer appear. We prove that DM is locally well-posed for H1 data (for fixed c), and that as c → ∞ the existence time grows at least as fast as log(c), provided the data are uniformly bounded in H1. Moreover, if the datum for the Dirac spinor converges in H1, then the solution of DM converges, modulo a phase correction, in C([0,T];H1) to a solution of a Schrödinger–Poisson system. Our results also apply to a mixed state formulation of DM, and give also a convergence result for the Pauli equation as the "semi-nonrelativistic" limit. The proof relies on modifications of the bilinear null form estimates of Klainerman and Machedon, and extends our previous work on the nonrelativistic limit of the Klein–Gordon–Maxwell system.
Popular Religiosity As an Internal Dynamic for the Local Church: The Case of Suriname
Authors: Wielzen Duncan 
Published: March 2005

AbstractThis essay reflects two aspects of being a local church. One regards the very way of life of a given people from a Christian perspective, a life being colored by what we call 'popular religiosity'. The fundamental question for this essay is to assess how popular religiosity shapes the existence of a local church. The other aspect considers an institutionalised form of a local church having notions, such as inculturation of the Gospel and the evangelization of cultures, as its hallmarks. At the end of this essay, it will be our contention that some forms of popular religiosity are imbued with an important internal dynamic which give meaning to the local church. This is interesting, because it creates the opportunity to be a local church in a way that goes against centralized and prescribed concepts of the church.
The Motif Of Si Anak Hilang in the Poetry Of Sitor Situmorang
Authors: Hoekema Alle 
Published: March 2005

AbstractRecently the Indonesian poet, novelist and essayist Sitor Situmorang reached the age of eighty. Situmorang has a Christian background; his origins are to be found in the Batak area in North Sumatra. His life and work have been summarized as 'to love, to wander'; in a way he has been a perennial wanderer and pilgrim, roaming around in many places of the world and being home, finally, in his poems. Part of his life he spent in prison as a political detainee. In this article we analyse the motif of 'the lost [prodigal] son' which occurs no less than four times in Situmorang's lyrical work, each time in a different context and with a different meaning. Connected with the role of the father and the mother and of a deep longing for his native village, this motif forms an important thread in his poetry, which often has religious allusions.
From the Fringes to the Centre: Pentecostalization of the Mainline Churches in Ghana
Authors: Omenyo Cephas 
Published: March 2005

AbstractIn this article, the author deals with the unprecedented integration of charismatic features in the ethos of the mainline churches of Ghana which respond to typical African questions thus rejuvenating those churches. He describes and analyses the way the charismatic phenomenon which began in the margins has become a central element of all the mainline historic churches in Ghana. While in the past the African Independent/Instituted churches and later Pentecostal and Neo–Pentecostal churches were noted for charismatic enthusiasm, currently the phenomenon has found its way into the mainline churches thus blurring the sharp distinction between mainline churches and Pentecostals. As a result, there is a major paradigmatic shift in the spirituality, theology, practices and programs of mainline churches in Ghana. Thus the phenomenon can no longer be regarded as peripheral in the life of the older Ghanaian churches.
Internal tandem duplications of the FLT3 gene are present in leukemia stem cells
Authors: Levis Mark , Murphy Kathleen M. , Pham Rosalyn , Kim Kyu-Tae , Stine Adam , Li Li , McNiece Ian , Smith B. Douglas , Small Donald 
Published: March 2005

Abstract
Internal tandem duplication mutations of the FLT3 gene (FLT3/ITD mutations) are the most frequent molecular abnormality in acute myeloid leukemia (AML) and are associated with a poor overall survival. While the normal FLT3 receptor is expressed in early hematopoietic progenitor cells, it has not been determined whether FLT3 mutations are present in the leukemic stem cells. In this study, we sorted primary AML samples into stem cell-enriched CD34+/CD38- fractions and then analyzed the sorted and unsorted cells for the FLT3 mutant-wild-type ratio. In each case, the FLT3 mutant-wild-type ratio was not changed by selection of CD34+/CD38- cells, implying that the mutations are present in the leukemic stem cells. We used the stem cell-enriched fraction to engraft nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice and then confirmed that the FLT3/ITD mutation was present in the resultant engrafted marrow. As a final test of the importance of FLT3/ITD signaling in this engraftment model, we used a small molecule FLT3 inhibitor, CEP-701, to inhibit engraftment of FLT3/ITD stem cells. Taken together, these experiments establish that the FLT3/ITD mutations are present in leukemia stem cells, and that FLT3 inhibitors may have activity against these cells. (Blood. 2005;106:673-680)
Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function
Authors: Détivaud Lénaïck , Nemeth Elizabeta , Boudjema Karim , Turlin Bruno , Troadec Marie-Bérengère , Leroyer Patricia , Ropert Martine , Jacquelinet Sylvie , Courselaud Brice , Ganz Tomas , Brissot Pierre , Loréal Olivier 
Published: March 2005

Abstract
Hepcidin, a key regulator of iron metabolism, is synthesized by the liver. Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes. We analyzed liver samples from patients undergoing hepatic surgery for cancer or receiving liver transplants and analyzed correlations between clinical parameters and liver hepcidin mRNA and urinary hepcidin concentrations. Despite the many potential confounding influences, urinary hepcidin concentrations significantly correlated with hepatic hepcidin mRNA concentrations, indicating that hepcidin quantification in urine is a valid approach to evaluate hepcidin expression. Moreover, we found in humans that hepcidin levels correlated with hepatic iron stores and hemoglobin levels and may also be affected by hepatic dysfunction. (Blood. 2005;106:746-748)
A long-term follow-up study on hepatitis B surface antigen–positive patients undergoing allogeneic hematopoietic stem cell transplantation
Authors: Hui Chee-kin , Lie Albert , Au Wing-yan , Leung Yu-hung , Ma Shing-yan , Cheung Winnie W. W. , Zhang Hai-ying , Chim Chor-sum , Kwong Yok-lam , Liang Raymond , Lau George K. K. 
Published: March 2005

Abstract
The long-term hepatic complications after allogeneic hematopoietic stem cell transplantation (HSCT) in hepatitis B virus (HBV) endemic area are unknown. We examined the serological and liver-related outcome of 803 consecutive patients who received allogeneic HSCTs, with a median follow-up period of 83 months (range, 0.5-155 months). Late HBV-related hepatitis occurred in 2 of the 721 hepatitis B surface antigen–negative (HBsAg–) recipients compared with 16 of the 82 HBsAg+ recipients after HSCT (0.3% vs 19.5%; P &lt; .001 by log-rank). Liver cirrhosis developed in 8 of the 82 HBsAg+ recipients compared with none of the 721 HBsAg– recipients (9.8% vs 0%; P &lt; .001 by log-rank). Twenty of the 31 (64.5%) HBsAg+ recipients of hematopoietic stem cells from donors with natural immunity to HBV had sustained serologic clearance of HBsAg after HSCT. Eight of the 62 recipients without sustained HBsAg clearance compared with none of the 20 recipients with sustained HBsAg clearance developed liver cirrhosis (12.9% vs 0%; P = .02 by log-rank). Our study showed that long-term hepatic complications occur in a significant proportion of HBsAg+ patients after HSCT and the incidence of liver cirrhosis is reduced in those with sustained serologic clearance of HBsAg after HSCT.
A2 gene of Old World cutaneous Leishmania is a single highly conserved functional gene
Authors: Garin Yves JF , Meneceur Pascale , Pratlong Francine , Dedet Jean-Pierre , Derouin Francis , Lorenzo Frédéric 
Published: March 2005

Abstract
Background
Leishmaniases are among the most proteiform parasitic infections in humans ranging from unapparent to cutaneous, mucocutaneous or visceral diseases. The various clinical issues depend on complex and still poorly understood mechanisms where both host and parasite factors are interacting. Among the candidate factors of parasite virulence are the A2 genes, a family of multiple genes that are developmentally expressed in species of the Leishmania donovani group responsible for visceral diseases (VL). By contrast, in L. major determining cutaneous infections (CL) we showed that A2 genes are present in a truncated form only. Furthermore, the A2 genomic sequences of L. major were considered subsequently to represent non-expressed pseudogenes [1]. Consequently, it was suggested that the structural and functional properties of A2 genes could play a role in the differential tropism of CL and VL leishmanias. On this basis, it was of importance to determine whether the observed structural/functional particularities of the L. major A2 genes were shared by other CL Leishmania, therefore representing a proper characteristic of CL A2 genes as opposed to those of VL isolates.

Methods
In the present study we amplified by PCR and sequenced the A2 genes from genomic DNA and from clonal libraries of the four Old World CL species comparatively to a clonal population of L. infantum VL parasites. Using RT-PCR we also amplified and sequenced A2 mRNA transcripts from L. major.

Results
A unique A2 sequence was identified in Old World cutaneous Leishmania by sequencing. The shared sequence was highly conserved among the various CL strains and species analysed, showing a single polymorphism C/G at position 58. The CL A2 gene was found to be functionally transcribed at both parasite stages.

Conclusion
The present study shows that cutaneous strains of leishmania share a conserved functional A2 gene. As opposed to the multiple A2 genes described in VL isolates, the CL A2 gene is unique, lacking most of the nucleotide repeats that constitute the variable region at the 5'end of the VL A2 sequences. As the variable region of the VL A2 gene has been shown to correspond to a portion of the protein which is highly immunogenic, the present results support the hypothesis of a possible role of the A2 gene in the differential tropism of CL and VL leishmania parasites.
Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography
Authors: Sasaki K , Tateoka N , Ando H , Yoshizaki F 
Published: March 2005

Abstract
We have evaluated the inhibitory activity of flavone, nobiletin, and heptamethoxyflavone on matrix metalloproteinase (MMP) activity in the rat. MMP in 9000-g supernatant fraction of lung homogenate was activated by p-aminophenyl mercuric acetate (APMA), and gelatinolytic activity was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) followed by Coomassie staining. This activity should be related to MMP-2 and/or MMP-9 and was confirmed by gelatin zymography. Fluorescent-conjugated collagen used as a substrate for collagenolytic activity was investigated by SDS-PAGE also. The film in-situ zymography method was applied to rat brain and lung tissue in the same manner. Flavone and nobiletin inhibited the APMA-stimulated gelatinolytic activity and also the collagenolytic activity by more than 75%. The film in-situ zymography method indicated that these compounds might be potent inhibitors of MMP, suggesting the specific inhibition of localized MMP in brain hippocampus and/or lung terminal bronchioles, which may contribute to the prevention of some types of brain disease or cancer invasion and metastasis.