bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the relationship between forced maximal flow at functional residual capacity and parameters of forced expiration from raised lung volume in healthy infants
Authors: Ranganathan S.C. , Hoo A.F. , Lum S.Y. , Goetz I. , Castle R.A. , Stocks J. 
Published: June 2004

AbstractThe raised volume rapid thoraco‐abdominal compression technique (RVRTC) is being increasingly used to assess airway function in infants, but as yet no consensus exists regarding the equipment, methods, or analysis of recorded data. The aim of this study was to explore the relationship between maximal flow at functional residual capacity (V′maxFRC) and parameters derived from raised lung volumes, and to address analytical aspects of the latter technique in an attempt to assist with future standardization initiatives. Forced vital capacity (FVC) from lung volume raised to 3 kPa, timed forced expiratory volumes (FEVt), and forced expiratory flow parameters at different percentages of expired FVC (FEF%) were measured in 98 healthy infants (1–69 weeks of age). V′maxFRC using the tidal rapid thoraco‐abdominal compression (RTC) technique was also measured. The within‐subject relationships and within‐subject variability of the various parameters were assessed.Duration of forced expiration was < 0.5 sec in 5 infants, meaning that FEV0.3 and FEV0.4 were the only timed volume parameters that could be calculated in all infants during the first months of life, and even when it could be calculated, FEV0.5 approached FVC in many of these infants. It is recommended that FEV0.4 be routinely reported in infants less than 3 months of age. Contrary to previous reports, within subject variability of V′maxFRC was less than that of FEF75 (mean CV = 6.3% and 8.9%, respectively).A more standardized protocol when analyzing data from the RVRTC would facilitate comparisons of results between centers in the future. Pediatr Pulmonol. 2002; 33:419–428. © 2002 Wiley‐Liss, Inc.
2MOLCAS as a development platform for quantum chemistry software
Authors: Veryazov Valera , Widmark Per‐Olof , Serrano‐Andrés Luis , Lindh Roland , Roos Björn O. 
Published: July 2004

AbstractThis work presents the quantum chemistry package MOLCAS, with emphasis on its usefulness as a platform for developing new quantum chemical codes, and the reader is assumed to be familiar with such a process. The development of new codes for quantum chemistry is a time‐consuming job that can be dramatically simplified by using libraries for standard problems (such as calculation of integrals), and tools to surmount computer language and operating system limitations. The MOLCAS quantum chemistry software contains modules for a variety of quantum chemical methods, such as Hartree–Fock (HF), density functional theory (DFT), coupled‐cluster (CC), and multiconfigurational (MCSCF) approaches, including second‐order perturbation theory. It runs on almost all UNIX‐like platforms and contains a single source code for 32‐ and 64‐bit architecture, as well as for serial and parallel execution. The MOLCAS environment allows the user to include, in a simple way, new codes integrated with libraries and other MOLCAS modules. The key features of the MOLCAS environment include a modular structure, an easy‐to‐use environment, an application programming interface (API) library for solving common computational and system‐oriented problems, a solid verification control system, and tools for a distributed development. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2004
Potential curves of the Be2 molecule in cylinder‐like cavities
Authors: Bogomolova A. Yu. , Ermilov A. Yu. , Scherbinin A. V. 
Published: July 2004

AbstractSpatial confinement effects on the energy states of the beryllium atom and the electronic states of the beryllium dimer molecule are studied. Confinement effects are modeled by systems of point charges. Electronic structure calculations are carried out on the basis of the frozen core full configuration interaction method. Atomic states are treated within the even‐tempered basis set 17s13p9d consisting of 110 primitive Gaussians. The valence and the Rydberg states of the spherically confined Be atom exhibit different behavior under the compression. Inversions of the atomic terms are discussed. The potential energy curves of the cylindrically confined Be2 molecule are calculated within the cc‐pVTZ basis set. The employed cylindrical point charge environment model is shown to introduce significant end effects which are diminishing as the length of the cylinder increases. In very short tubes the above end effects may introduce additional changes into the molecular energy level picture. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2004
Simple model of H+ and H(1s) collision: Application to charge transfer
Authors: Deineka G. B. 
Published: June 2004

AbstractA numerical method for calculation time‐dependent process in collision of H+ and H(1s) is introduced. The method utilizes the finite basis set of hermitian B‐splines for calculation of localized and nonlocalized states in 1D model. The space resonance effect of electron density polarization oscillations during the propagation of projectile is considered. The charge transfer dependence on the oscillation phase of polarization is presented. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2004
Performance‐Based Approaches to Human Resource Development
Authors: Holmes Tyrone A. 
Published: July 2004

AbstractMuch has been written about the professional practice of human resource development (HRD). This chapter examines performance‐based HRD practices and their relevance for student affairs. It provides a general overview of HRD, including discussion of the newest concepts in the field, and offers a model and tools for applying performance‐based HRD within higher education institutions.
Influence and Impact: Professional Development in Student Affairs
Authors: Cooper Diane L. , Miller Theodore K. 
Published: July 2004

AbstractThis chapter explores the impact of mentoring on those entering and advancing in the field of student affairs, the protégés; those providing professional development support, the mentors; and the organizations that they serve. It incorporates findings from a national survey of practitioner members of the National Association of Student Personnel Administrators (NASPA).
Observations, Reflections, and Speculations: What We Have Learned About the Scholarship of Teaching and Where It Might Lead
Authors: Kreber Carolin 
Published: June 2004

AbstractKnowing what constitutes the scholarship of teaching and how to assess and promote it is an important accomplishment. Yet where does teaching excellence fit in? Should it be valued also and, if so, how? This chapter considers this issue by revisiting what has been learned from this volume.
Mentoring in the Technical Disciplines: Fostering a Broader View of Education, Career, and Culture In and Beyond the Workplace
Authors: Marra Rose M. , Pangborn Robert N. 
Published: June 2004

AbstractExamples of mentoring in engineering are provided as models for how to relate to students beyond the traditional classroom format. Mentoring expands the opportunities to interact with students and provides rewards for both students and the faculty mentors.
Using the ARCS Motivational Process in Computer‐Based Instruction and Distance Education
Authors: Keller John M. 
Published: June 2004

AbstractIt is one thing to design for learner motivation in a classroom where teachers can respond to students' cues. It is a greater challenge to make self‐directed learning environments responsive to the motivational requirements of learners. This chapter describes a process that provides guidelines and methods for incorporating motivational tactics into computer‐based and distance learning environments.
Two New Benzoate‐di(methylcyclopentadienyl)ytterbium(III) Complexes: [Yb(MeCp)2(O2CC6F5)]2 and [Yb(MeCp)2(O2C‐o‐HC6F4)]2
Authors: Deacon Glen B. , Quitmann Catharina C. , Müller‐Buschbaum Klaus , Meyer Gerd 
Published: June 2004

AbstractTransparent orange crystals of [Yb(MeCp)2(O2CC6F5)]2 and [Yb(MeCp)2(O2C‐o‐HC6F4)]2 were obtained by oxidation of Yb(MeCp)2 with M(O2CR) (M = 1/2 Hg, Tl; R = C6F5, o‐HC6F4) in tetrahydrofuran. They have a dimeric structure with bridging bidentate (O, O')‐benzoate groups and eight coordinated ytterbium. Both crystallise isotypic in the orthorhombic space group Pbca. Room temperature as well as low temperature single crystal X‐ray investigations show the o‐H/F positions in [Yb(MeCp)2(O2C‐o‐HC6F4)]2 not to be ordered.
Synthesis and the Unique Crystal Structure of [(H2O)⊂(DB18C6)(μ2‐H2O)2/2][(H3O)⊂(DB18C6)(μ2‐H2O)2/2]I3 (DB18C6 = dibenzo‐18‐crown‐6)
Authors: Fromm Katharina M. , Gueneau Estelle D. , Goesmann Helmut , Bochet Christian G. 
Published: June 2004

AbstractIn the title compound 1, the macrocylic ligand DB18C6 arranges to build two types of channels in which either only water or water and H3O+ molecules are stacked to linear polymers. The counter ions, I3—, also form chains and fill in the spaces left between the parallel stacks of the crown ethers. Compound 1 should therefore possess interesting conducting properties and might as well serve as model for biological water channels.
Synthese und Struktur eines Pentaalkylchlorohexastibans Sb6R5Cl [R = (Me3Si)2CH]
Authors: Balázs G. , Breunig H. J. , Lork E. 
Published: June 2004

AbstractBei der Umsetzung von RSbCl2 [R = (Me3Si)2CH] mit Na‐K‐Legierung in Tetrahydrofuran entsteht neben den bekannten Ringen SbnRn (n = 3, 4) und (Me3Si)2CH2 das Pentaalkylchlorohexastiban Sb6R5Cl (1) in 5 % Ausbeute. 1 wurde durch MS, 1H‐, 13C‐NMR und Röntgenstrukturanalyse charakterisiert. Die Struktur von 1 besteht aus einem gefalteten Antimon‐Vierring in der all‐trans‐Konfiguration mit drei Alkylgruppen und einem Sb(R)—Sb(R)Cl‐Fragment als Substituenten.
Topiramate modulates pH of hippocampal CA3 neurons by combined effects on carbonic anhydrase and Cl−/HCO3− exchange
Authors: Leniger Tobias , Thöne Jan , Wiemann Martin 
Published: July 2004

Topiramate (TPM) is an anticonvulsant whose impact on firing activity and intracellular pH (pHi) regulation of CA3 neurons was investigated.
Using the 4‐aminopyridine‐treated hippocampal slice model bathed in bicarbonate‐buffered solution, TPM (25–50 μM) reduced the frequency of epileptiform bursts and action potentials without affecting membrane potential or input resistance. Inhibitory effects of TPM were reversed by trimethylamine‐induced alkalinization.
TPM also lowered the steady‐state pHi of BCECF‐AM‐loaded neuronal somata by 0.18±0.07 pH units in CO2/HCO3−‐buffered solution. Subsequent to an ammonium prepulse, TPM reduced the acidotic peak but clearly slowed pHi recovery. These complex changes were mimicked by the protein phosphatase inhibitor okadaic acid.
Alkalosis upon withdrawal of extracellular Cl− was augmented by TPM. Furthermore, at decreased pHi due to the absence of extracellular Na+, TPM reversibly increased pHi. These findings demonstrate that TPM modulates Na+‐independent Cl−/HCO3− exchange.
In the nominal absence of extracellular CO2/HCO3− buffer, both steady‐state pHi and firing of epileptiform bursts remained unchanged upon adding TPM. However, pHi recovery subsequent to an ammonium prepulse was slightly increased, as was the case in the presence of the carbonic anhydrase (CA) inhibitor acetazolamide. Thus, a slight reduction of intracellular buffer capacity by TPM may be due to an inhibitory effect on intracellular CA.
Together, these findings show that TPM lowers neuronal pHi most likely due to a combined effect on Na+‐independent Cl−/HCO3− exchange and CA. The apparent decrease of steady‐state pHi may contribute to the anticonvulsive property of TPM.

British Journal of Pharmacology (2004) 142, 831–842. doi:10.1038/sj.bjp.0705850
Stimulus‐specific defect in the phagocytic pathways of annexin 1 null macrophages
Authors: Yona Simon , Buckingham Julia C , Perretti Mauro , Flower Roderick J 
Published: July 2004

The role of the glucocorticoid‐regulated protein annexin 1 during the process of phagocytosis has been studied using annexin 1 null peritoneal macrophages. Wild type and annexin 1 null macrophages were incubated with several distinct phagocytic targets. No differences were observed in rate or the maximal response with respect to IgG complexes or opsonised zymosan phagocytosis, as assessed by monitoring the production of reactive oxygen species.
When annexin 1 null macrophages were incubated with non‐opsonised zymosan particles, they exhibited impaired generation of reactive oxygen species, which was linked to a defect in binding of cells to the particles, as determined with fluorescent zymosan. This phenomenon was further confirmed by electron microscopy analysis, where annexin 1 null macrophages internalised fewer non‐opsonised zymosan particles.
Specific alterations in macrophage plasma membrane markers were observed in the annexin 1 null cells. Whereas no differences in dectin‐1 and FcγR II/III expression were measured between the two genotypes, decreased membrane CD11b and F4/80 levels were measured selectively in macrophages lacking annexin 1.
These cells also responded with an enhanced release of PGE2 and COX‐2 protein expression following addition of the soluble stimulants, LPS and heat‐activated IgG.
In conclusion, these results suggest that participation of endogenous annexin 1 during zymosan phagocytosis is critical and that this protein plays a tonic inhibitory role during macrophage activation.

British Journal of Pharmacology (2004) 142, 890–898. doi:10.1038/sj.bjp.0705858
Molecular pharmacological profile of the nonredox‐type 5‐lipoxygenase inhibitor CJ‐13,610
Authors: Fischer Lutz , Steinhilber Dieter , Werz Oliver 
Published: July 2004

5‐Lipoxygenase (5‐LO) is a crucial enzyme in the synthesis of the bioactive leukotrienes (LTs) from arachidonic acid (AA), and inhibitors of 5‐LO are thought to prevent the untowarded pathophysiological effects of LTs.
In this study, we present the molecular pharmacological profile of the novel nonredox‐type 5‐LO inhibitor CJ‐13,610 that was evaluated in various in vitro assays.
In intact human polymorphonuclear leukocytes (PMNL), challenged with the Ca2+‐ionophore A23187, CJ‐13,610 potently suppressed 5‐LO product formation with an IC50=0.07 μM. Supplementation of exogenous AA impaired the efficacy of CJ‐13,610, implying a competitive mode of action.
In analogy to ZM230487 and L‐739.010, two closely related nonredox‐type 5‐LO inhibitors, CJ‐13,610 up to 30 μM failed to inhibit 5‐LO in cell‐free assay systems under nonreducing conditions, but inclusion of peroxidase activity restored the efficacy of CJ‐13,610 (IC50=0.3 μM).
In contrast to ZM230487 and L‐739.010, the potency of CJ‐13,610 does not depend on the cell stimulus or the activation pathway of 5‐LO. Thus, 5‐LO product formation in PMNL induced by phosphorylation events was equally suppressed by CJ‐13,610 as compared to Ca2+‐mediated 5‐LO activation. In transfected HeLa cells, CJ‐13,610 only slightly discriminated between phosphorylatable wild‐type 5‐LO and a 5‐LO mutant that lacks phosphorylation sites.
In summary, CJ‐13,610 may possess considerable potential as a potent orally active nonredox‐type 5‐LO inhibitor that lacks certain disadvantages of former representatives of this class of 5‐LO inhibitors.

British Journal of Pharmacology (2004) 142, 861–868. doi:10.1038/sj.bjp.0705860
Recognition of multiple patterns in unaligned sets of sequences: comparison of kernel clustering method with other methods
Authors: Kel A. , Tikunov Y. , Voss N. , Wingender E. 
Published: July 2004

Abstract
Motivation: Transcription factor binding sites often differ significantly in their primary sequence and can hardly be aligned. Often one set of sites can contain several subsets of sequences that follow not just one but several different patterns. There is a need for sensitive methods to reveal multiple patterns in unaligned sets of sequences.
Results: We developed a novel method for analysis of unaligned sets of sequences based on kernel estimation. The method is able to reveal ‘multiple local patterns’—a set of weight matrices. Every weight matrix characterizes a pattern that can be found in a significant subset of sequences under analysis. The method developed has been compared with several other methods of pattern discovery such as Gibbs sampling, MEME, CONSENSUS, MULTIPROFILER and PROJECTION. The kernel method showed the best performance in terms of how close the revealed weight matrices are to the original ones. We applied the kernel method to analyze three samples of promoters (cell-cycle, T-cells and muscle-specific). We compared the multiple patterns revealed with the TRANSFAC library of weight matrices and found a strong similarity to several weight matrices for transcription factors known to be involved in the mentioned specific gene regulation.
Availability: The program is available for on-line use at: http://www.biobase.de/cgi-bin/biobase/cbs2/bin/template.cgi?template=cbscall.html
New methods for joint analysis of biological networks and expression data
Authors: Sohler Florian , Hanisch Daniel , Zimmer Ralf 
Published: July 2004

Abstract
Summary: Biological networks, such as protein interaction, regulatory or metabolic networks, derived from public databases, biological experiments or text mining can be useful for the analysis of high-throughput experimental data. We present two algorithms embedded in the ToPNet application that show promising performance in analyzing expression data in the context of such networks. First, the Significant Area Search algorithm detects subnetworks consisting of significantly regulated genes. These subnetworks often provide hints on which biological processes are affected in the measured conditions. Second, Pathway Queries allow detection of networks including molecules that are not necessarily significantly regulated, such as transcription factors or signaling proteins. Moreover, using these queries, the user can formulate biological hypotheses and check their validity with respect to experimental data. All resulting networks and pathways can be explored further using the interactive analysis tools provided by ToPNet program.
Efficient similarity search in protein structure databases by k-clique hashing
Authors: Weskamp Nils , Kuhn Daniel , Hüllermeier Eyke , Klebe Gerhard 
Published: July 2004

Abstract
Motivation: Graph-based clique-detection techniques are widely used for the recognition of common substructures in proteins. They permit the detection of resemblances that are independent of sequence or fold homologies and are also able to handle conformational flexibility. Their high computational complexity is often a limiting factor and prevents a detailed and fine-grained modeling of the protein structure.
Results: We present an efficient two-step method that significantly speeds up the detection of common substructures, especially when used to screen larger databases. It combines the advantages from both clique-detection and geometric hashing. The method is applied to an established approach for the comparison of protein binding-pockets, and some empirical results are presented.
Availability: Upon request from the authors.
Vascular Endothelial Growth Factor Overexpression Increases Vascularization by Murine But Not Human Endothelial Cells in Cultured Skin Substitutes Grafted to Athymic Mice
Authors: Supp Dorothy M. , Karpinski Andrea C. , Boyce Steven T. 
Published: July 2004

Abstract
Cultured skin substitutes (CSS) consisting of fibroblasts, keratinocytes, and biopolymers are an adjunctive treatment for large burns. Because CSS lack a vascular plexus, they vascularize more slowly than split-thickness autografts. Previously, CSS were prepared with dermal microvascular endothelial cells (ECs), which formed vascular analogs at a low frequency but did not contribute to increased vascularization after grafting. The present study addressed whether keratinocytes genetically modified to overexpress vascular endothelial growth factor (VEGF), an endothelial cell mitogen, could improve the persistence and organization of ECs in CSS. CSS were prepared with control or VEGF-modified keratinocytes, with (CSS + ECs) or without added ECs, and were grafted to full-thickness wounds in athymic mice. Elevated VEGF expression was detected in VEGF-modified CSS and CSS + ECs compared with controls, but no significant difference in EC density in vitro was observed. After grafting, VEGF-modified CSS and CSS + ECs showed enhanced vascularization, and organization of human ECs into multicellular structures in CSS + ECs was observed. However, VEGF overexpression did not significantly enhance the proliferation of human ECs, suggesting that other factors may be required. Improved persistence and organization of human ECs in vitro will likely be required for their participation in vascularization of CSS + ECs after grafting.
Buses as Fire Hazards: A Swedish Problem Only? Suggestions for Fire-Prevention Measures
Authors: Huss Fredrik R. M. , Erlandsson U. , Sjöberg F. 
Published: July 2004

Abstract
In Sweden, approximately 6% of all human transportation is made via buses. The Swedish Board of Accident Investigation and the Swedish Rescue Services Agency have pointed out repeatedly that buses are potential fire and burn hazards, not only when involved in collisions but also in other circumstances. The number of fire incidents is increasing, especially in newer buses. In conjunction with the Swedish Rescue Services Agency, we examined some of the recent bus fires in Sweden. We did not find any casualties, but the results of our study suggest that casualties as a result of bus fires are imminent unless preventive measures are taken. We also studied experiences from previous bus fires and suggest preventive measures.
A History of the Development of Muscle Perforator Flaps and Their Specific Use in Burn Reconstruction
Authors: Hallock G. G. 
Published: July 2004

Abstract
Only rarely does coverage in the burn patient require the use of a vascularized flap. However, when mandatory, a knowledge of all alternatives is essential because common donor sites may have been badly burned and unavailable. The recent development of the muscle perforator flap may prove to be another valuable option. These flaps are nourished by the familiar musculocutaneous perforators but differ in that their complete intramuscular dissection is required during flap elevation so that no muscle need be included with the flap. A review of six cases using muscle perforator free flaps specifically for burn reconstruction or rehabilitation demonstrates how the same large cutaneous territory of a musculocutaneous flap can still be captured while the muscle and therefore its function is preserved.
Use of Free Serratus Anterior Muscle Slips for the Reconstruction of Dorsal-Side Defects of the Hand Resulting From Hot Press Injury
Authors: Topalan Murat , Özden Burcu Çelet , Aydin Atakan , Erer Metin 
Published: July 2004

Abstract
Mutilation of the hand as a result of hot press injury, the common characteristics of which are extensive soft tissue and extensor tendon loss, metacarpal and phalangeal necrosis, exposition of multiple joints, and infection, presents a serious challenge to the hand surgeon. Free transfer of the inferior three slips of the serratus anterior muscle is a useful surgical option for the reconstruction of dorsal-side defects in the hand. The versatility of the three separate slips, which are easily divisible for contouring, enables individual reconstruction of the different digits. Long vascular pedicle, low donor-site morbidity, and durability are other advantages. Four male patients with hot press injury of the dorsal side of the hand were treated with free transfer of serratus anterior muscle slips and split-thickness skin grafts. Follow-up period ranged between 5 and 12 years. Late functional and cosmetic results are presented.