bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models
Authors: Zhang Yanjun , Sun Jing , Zheng Jian , Li Suxiang , Rao Haiyue , Dai Jun , Zhang Zhaoyong , Wang Yanqun , Liu Donglan , Chen Zhao , Ran Wei , Zhu Airu , Li Fang , Yan Qihong , Wang Yiliang , Yu Kuai , Zhang Shengnan , Wang Dong , Tang Yanhong , Liu Banghui , Cheng Linling , Huo Jiandong , Perlman Stanley , Zhao Jingxian , Zhao Jincun 
Published: December 2023

AbstractTo combat SARS‐CoV‐2 variants and MERS‐CoV, as well as the potential re‐emergence of SARS‐CoV and spillovers of sarbecoviruses, which pose a significant threat to global public health, vaccines that can confer broad‐spectrum protection against betacoronaviruses (β‐CoVs) are urgently needed. A mosaic ferritin nanoparticle vaccine is developed that co‐displays the spike receptor‐binding domains of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 Wild‐type (WT) strain and evaluated its immunogenicity and protective efficacy in mice and nonhuman primates. A low dose of 10 µg administered at a 21‐day interval induced a Th1‐biased immune response in mice and elicited robust cross‐reactive neutralizing antibody responses against a variety of β‐CoVs, including a series of SARS‐CoV‐2 variants. It is also able to effectively protect against challenges of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 variants in not only young mice but also the more vulnerable mice through induction of long‐lived immunity. Together, these results suggest that this mosaic 3‐RBD nanoparticle has the potential to be developed as a pan‐β‐CoV vaccine.
Freezing Halide Segregation Under Intense Light for Photostable Perovskite/Silicon Tandem Solar Cells
Authors: Qiao Liang , Ye Tianshi , Wang Tao , Kong Weiyu , Sun Ruitian , Zhang Lin , Wang Pengshuai , Ge Zhizhong , Peng Yong , Zhang Xiaodan , Xu Menglei , Yan Xunlei , Yang Jie , Zhang Xinyu , Zeng Fang , Han Liyuan , Yang Xudong 
Published: December 2023

AbstractPhoto‐induced halide segregation in wide‐bandgap (WBG) perovskite leads to poor stability and limits its application in high‐efficiency tandem solar cells. Here, a simple solution strategy to achieve photostable WBG perovskite solar cells (PSCs) with bandgap of ≈1.67 eV by ionic coupling potassium sorbate with defects at the buried perovskite interface is reported. Moreover, the ionic coupled potassium sorbate (ICPS) enables to control the formation of N‐methyl formamidinium ions that can selectively passivate the perovskite defects at grain boundaries. As a result, the photo‐induced halide segregation in the target perovskite films is frozen under intense light. The target single‐junction WBG PSC achieves a record efficiency of 22.00% with an open‐circuit voltage (VOC) of 1.272 V and photostability of less than 2% decay over 2000 h of operation. Perovskite/Silicon tandem solar cells are also fabricated that achieve an efficiency of 30.72% (certified 30.09% @1.087 cm2), which is the highest efficiency reported to date with a tunneling oxide passivating contact (TOPCon) c‐Si substrate. The encapsulated tandem device can maintain 97% of its initial efficiency after 1000 h of operation.
Molecular‐level insight on CO2 electroreduction to formate facilitated by triazole ionic liquid interfacial microhabitat
Authors: Peng Kuilin , Zeng Shaojuan , Li Guilin , Jiang Chongyang , Wang Chenlu , Yuan Lei , Bai Lu , Zhang Xiangping 
Published: December 2023

AbstractThe interfacial microhabitat induced by functionalized ionic liquid (IL) electrolyte can effectively improve product selectivity for CO2 electroreduction. The multiple interactions in IL electrolytes affect the ions, CO2, proton distribution, and the protonation reaction, which are relevant to product selectivity. However, the specific effects are still unclear. Herein, molecular dynamics simulation and density functional theory were combined to reveal the regulatory mechanisms. The results showed that the dipolar interaction between CO2 and [124Triz]− cooperating the hydrogen bonds between [124Triz]− and H2O facilitates the accumulation of H atoms around C atoms of CO2. Moreover, the strong polar [124Triz]− induces protons to attack the C atoms of CO2, which results in lower free energy (−0.10 eV) for the formation of *HCOO intermediate and promotes the formation of formate, compared with the free energy of 0.43 eV for [NTf2]−. This work reveals the [124Triz]− regulatory mechanism for high formate selectivity.
Diagnostic capabilities, clinical features, and longitudinal UBA1 clonal dynamics of a nationwide VEXAS cohort
Authors: Gurnari Carmelo , Pascale Maria Rosaria , Vitale Antonio , Diral Elisa , Tomelleri Alessandro , Galossi Elisa , Falconi Giulia , Bruno Alessandro , Crisafulli Francesca , Frassi Micol , Cattaneo Chiara , Bertoli Diego , Bernardi Massimo , Condorelli Annalisa , Morsia Erika , Poloni Antonella , Crisà Elena , Caravelli Daniela , Triggianese Paola , Brussino Luisa , Battipaglia Giorgia , Bindoli Sara , Sfriso Paolo , Caroni Federico , Dragani Matteo , Mallegni Flavia , Pilo Federica , Firinu Davide , Curti Antonio , Papayannidis Cristina , Olivieri Attilio , Kordasti Sharham , Albano Francesco , Pane Fabrizio , Musto Pellegrino , Bocchia Monica , Lugli Elisabetta , Breccia Massimo , Frigeni Marco , Dagna Lorenzo , Greco Raffaella , Franceschini Franco , Campochiaro Corrado , Cantarini Luca , Voso Maria Teresa 
Published: December 2023

AbstractVEXAS is a prototypic hemato‐inflammatory disease combining rheumatologic and hematologic disorders in a molecularly defined nosological entity. In this nationwide study, we aimed at screenshotting the current diagnostic capabilities and clinical‐genomic features of VEXAS, and tracked UBA1 longitudinal clonal dynamics upon different therapeutics, including allogeneic hematopoietic cell transplant. We leveraged a collaboration between the Italian Society of Experimental Hematology and of Rheumatology and disseminated a national survey to collect clinical and molecular patient information. Overall, 13/29 centers performed UBA1 genomic testing locally, including Sanger sequencing (46%), next‐generation sequencing (23%), droplet digital polymerase chain reaction (8%), or combination (23%). A total of 41 male patients were identified, majority (51%) with threonine substitutions at Met41 hotspot, followed by valine and leucine (27% and 8%). Median age at VEXAS diagnosis was 67 years. All patients displayed anemia (median hemoglobin 9.1 g/dL), with macrocytosis. Bone marrow vacuoles were observed in most cases (89%). The most common rheumatologic association was polychondritis (49%). A concomitant myelodysplastic neoplasm/syndrome (MDS) was diagnosed in 71% of patients (n = 28), chiefly exhibiting lower Revised International Prognostic Scoring System risk profiles. Karyotype was normal in all patients, except three MDS cases showing ‐Y, t(12;16)(q13;q24), and +8. The most frequently mutated gene was DNMT3A (n = 10), followed by TET2 (n = 3). At last follow‐up, five patients died and two patients progressed to acute leukemia. Longitudinal UBA1 clonal dynamics demonstrated mutational clearance following transplant. We collected a nationwide interdisciplinary VEXAS patient cohort, characterized by heterogeneous rheumatologic manifestations and treatments used. MDS was diagnosed in 71% of cases. Patients exhibited various longitudinal UBA1 clonal dynamics.
Lewis Base Catalyzed C−S Bond Formation Through Methyl C(sp3)‐H Thiocyanation of Indoles
Authors: Qumruddeen  , Kumar Dileep , Jose Jobsy , Tripathi Chandra Bhushan 
Published: December 2023

AbstractA Lewis base catalyzed C−S bond formation through thiocyanation of methyl C(sp3)−H bond is reported. The method involves a sequential chlorination and thiocyanation reaction. This simple yet effective protocol works with diverse array of indoles to furnish thiocyanated products in good yield (up to 85 %). The developed method is also applied for the synthesis of phercaptoline (hypotensive agent) and umifenovir (antiviral drug).
Recent Progress Toward Total Syntheses of Iheyamines A and B
Authors: Kim Tae Lyn , Jeon Jiye , Lee Yong Ho , Cheon Cheol‐Hong 
Published: December 2023

AbstractThis perspective article describes the recent progress in the total syntheses of iheyamines A and B. Since iheyamine A possesses a highly unique unsymmetrical azepino‐2,2’‐bisindole scaffold, novel strategies to construct the basic scaffold have been developed, and unique total syntheses have been reported based on these strategies. In addition, because iheyamine B bears vicinal 2‐oxopropyl moieties with a trans‐configuration in the azepine scaffold of iheyamine A, the first asymmetric total synthesis of iheyamine B took a substantially longer time than iheyamine A to complete. Due to the unusual structure of iheyamine B and some discrepancies in the experimental data between the isolated and synthesized iheyamine B, some controversial issues regarding whether iheyamine B is a natural product or an artifact have been raised and will be discussed.
A Flexible Synthesis of Polypropionates via Diastereodivergent Reductive Ring‐Opening of Trisubstituted Secondary Glycidols
Authors: Pieper Katharina , Bleith Robin , Köhler Christian , Mika Regine , Gansäuer Andreas 
Published: December 2023

AbstractPolypropionates, characterized by their alternating sequence of stereocenters bearing methyl‐ and hydroxy‐groups, are structurally diverse natural products of utmost importance.[1] Herein, we introduce a novel concept approach towards polypropionate synthesis featuring a diastereodivergent reductive epoxide‐opening as a key step. Readily available and stereochemically uniform trisubstituted sec‐glycidols serve as branching points for the highly selective synthesis of all isomers of polypropionate building blocks with three or more consecutive stereocenters. Stereodiversification is accomplished by an unprecedented mechanism‐control over the stereochemically complementary modification of the epoxide's tertiary C‐atom with excellent control of regio‐ and stereoselectivity. Since our method is not only suited for the preparation of specific targets but also for compound libraries, it will have a great impact on polypropionate synthesis.
Effects of stearic acid on the tensile properties of ultrahigh molecular weight polyethylene fibers
Authors: Wang Yi , Wang Xinwei , Wang Yanling , Yu Junrong , Wang Yan , Hu Zuming 
Published: December 2023

AbstractFor the purpose of the development of ultrahigh molecular weight polyethylene (UHMWPE) fibers with improved tensile properties, the stearic acid (SA) was added to the gel spinning of UHMWPE and acted as a lubricant film. SA addition was intended to be 0.2, 0.4, 0.6, 0.8, and 1.0 wt% of UHMWPE for forming the SA modified UHMWPE fibers. The tensile properties, thermal properties, crystallization properties, and orientation properties of the prepared UHMWPE fibers were systematically investigated. Results show that there is a more significant tensile property for UHMWPE fibers as SA addition is 0.6 wt%. Their tensile strength and tensile modulus reach 32.86 and 1580.89 cN/dtex, which are raised to an extent of 12.0% and 7.7%, respectively, compared with UHMWPE fibers alone. Moreover, the thermal properties, crystallization properties, and orientation properties of the prepared UHMWPE fibers are enhanced observably when the SA addition is 0.6 wt%.
Surface‐enhanced Raman scattering of carbazole‐based covalent triazine framework
Authors: Kong Fan , Zhang Shuting , Ding Shounian 
Published: December 2023

AbstractA kind of carbazole‐based covalent triazine framework (CTF‐Cz) has been synthesized from a carbazole derivative. The porous polymer can efficiently adsorb probe molecules due to the strong intermolecular interactions caused by the polar triazine moiety. CTF‐Cz directly serves as the surface‐enhanced Raman scattering substrate without any post proceeding techniques. The enhancement factor of CTF‐Cz is ~105 for detecting rhodamine 6G (R6G). The lowest unoccupied molecular orbital energy level of CTF‐Cz (−3.93 eV) is much lower than that of R6G, which is in favor of the charge transfer from R6G to CTF‐Cz for illumination under a 532 nm laser, which is proved by time resolved photoluminescence spectra. The efficient charge transfer induced by the strong intermolecular π–π interactions and large molecular‐orbital delocalization contribute to the enhanced Raman signals of R6G on CTF‐Cz.
Peridynamic assessment of mechanical and thermal characteristics of a defected PMMA/HA composite beam
Authors: Akhlaghi‐Fard Soheil , Hosseini Safari Keivan , Mashhadi Mahmoud Mousavi 
Published: December 2023

AbstractPolymer‐based composites are designed to improve mechanical and thermal characteristics. This study utilized a peridynamic methodology to simulate polymethyl methacrylate/hydroxyapatite composite beams. The simulation involved the crack growth within the computational domain, and an analysis was conducted to evaluate the mechanical and thermal properties of the defected system. The outcomes derived from the peridynamic analysis revealed that an augmentation in the hydroxyapatite ratio within the samples resulted in a decrease in their mechanical and thermal efficiencies. To elucidate further, at an impact velocity of 2 mm/s, the flexural modulus increased to 3.69 GPa, the flexural strength decreased to 132.34 MPa, and the thermal conductivity converged to 0.148 W/m·K, when the hydroxyapatite ratio was at 15%. In the course of the conducted investigations, it became evident that the impact velocity significantly influences the evolutionary behavior of particles within the samples. In particular, with an increase in the impact velocity up to 5 mm/s, the thermal conductivity decreased to 0.139 W/m·K. The results of this study indicate that by modifying the hydroxyapatite ratio and impact velocity, it is possible to control the mechanical and thermal properties of the polymethyl methacrylate/hydroxyapatite composite beams. This optimization allows for their suitability in various engineering applications.
Synthesis of thermoset elastomer from microbial oil derived from the fermentation of sugarcane
Authors: Capeto Ana Paula , Uribe Braian Buitrago , Pintado Manuela , Guimarães Ana Sofia , Oliveira Ana L. S. 
Published: December 2023

AbstractIn the context of the 21st century, the integration of diverse perspectives within the circular economy framework, encompassing waste management, economic growth, and environmental sustainability, stands out as a paramount challenge. Addressing this challenge, an innovative avenue emerges through the application of microbial oil to replace traditional petroleum in the synthesis of essential commodity chemicals. This groundbreaking study takes a significant step toward this goal by introducing a pioneering polyester material boasting an exceptionally high renewable content. This material is synthesized through melt polycondensation, utilizing a novel primary feedstock derived from the oily residue extracted post‐distillation of β‐farnesene (FDR). The ingenious approach involves fermenting sugarcane syrup using a genetically engineered yeast strain of Saccharomyces cerevisiae. The outcome of this study reveals the creation of an amorphous polymer with rubber‐like attributes. These attributes include a Young's modulus of 3.9 MPa, with a maximum elastic strain and tensile stress values of 185.4% and 510 KPa, respectively, along with distinctive strain‐hardening characteristics. Remarkably, this material also exhibits indications of shape memory behavior in a temperature range spanning from −47 to 12°C, as discerned from dynamic mechanical analysis. Evidently, this novel polymer demonstrates exceptional promise in the realm of low‐temperature applications. Its intrinsic ability to uphold mechanical integrity, even when subjected to substantial deformations within its service conditions, positions it as an invaluable resource for various components requiring resilience in challenging environments.
3‐Halochromones Through Oxidative α‐Halogenation of Enaminones and its Photophysical Investigation: Another Case of Photo‐induced Partially Aromatised Intramolecular Charge Transfer?
Authors: Neto José S. S. , Coelho Filipe T. , Doerner Carlos V. , Braga Antonio L. , Lião Luciano M. , Coelho Felipe L. 
Published: December 2023

AbstractA versatile synthesis strategy for fluorescent 3‐halo‐4H‐chromen‐4‐one derivatives is reported. The method involves the oxidative α‐halogenation of enaminones performed by an efficient and sustainable oxidation system. The use of Oxone® in combination with KCl, KBr, or KI enables the preparation of 3‐chloro‐, 3‐bromo‐, or 3‐iodo‐4H‐chromen‐4‐one in good to excellent yields, with great functional group tolerance where the protocol is amenable to gram‐scale synthesis. The analysis of the photophysical properties of the presented 4H‐chromen‐4‐one showed absorption in the UV region and fluorescence emission in the violet‐to‐cyan region with a relatively large Stokes shift. In solution, all compounds present a dual fluorescence emission, regardless of the solvent, assigned to a partially aromatised intramolecular charge transfer mechanism, considering the presence of a pseudo‐aromatic ring in the chromone scaffold and the absence of the influence of substituent electronic features in optical behaviour.
Highly magnetized quark matter in the chiral limit
Authors: Ferraris S. A. , Carlomagno J. P. , Grunfeld A. G. 
Published: December 2023

AbstractWe examine the behavior of highly magnetized two‐light‐flavor quark matter within the context of a nonlocal NJL‐type model. This analysis assumes the chiral limit and incorporates the interaction between fermions and the Polyakov loop. Our calculations utilize a covariant Gaussian form factor. We present phase diagrams on the plane, illustrating different magnetic field strengths. Additionally, we examine the critical endpoint's placement and the de Haas‐Van Alphen transitions within the chiral restored phase, observing their temperature‐dependent characteristics.
Genetic variants in BCL‐2 family genes influence the risk of non‐syndromic cleft lip with or without cleft palate
Authors: Cui Xing , Zhu Guirong , Han Minxuan , Li Xiaofeng , Lou Shu , Xing Changyue , Xu Shuangbo , Pan Yongchu , Wang Lin 
Published: December 2023

AbstractBackgroundThe BCL‐2 family is crucial for cell death regulation and is involved in development, tissue homeostasis, and immunity. This study aimed to investigate the association between genetic variants in BCL‐2 family genes and non‐syndromic cleft lip with or without cleft palate (NSCL/P) risk.MethodsA two‐stage case–control study was conducted in this association study. Gene‐based analysis using Multi‐marker Analysis of GenoMic Annotation was performed in the first stage cohort, which included 565 cases and 1269 controls. A logistic regression model was employed to assess the effect of single nucleotide polymorphisms (SNPs) on susceptibility to NSCL/P. Candidate SNPs were replicated by extra dbGaP case‐parent trios. Haploreg, RegulomeDB, and UCSC Genome Browser were used to identify enhancer effects of promising SNPs. Bulk RNA sequencing data obtained from the Gene Expression Omnibus was used to identify co‐expressed genes. Single‐cell RNA sequencing dataset was used to infer the cell population of the candidate gene. The “Monocle” package was used to analyze the pseudotime cell trajectories.ResultsRs3943258 located in the enhancer region was associated with the risk of NSCL/P (Pmeta = 5.66 × 10−04) and exhibited an eQTL effect for BCL2 (P = 3.96 × 10−02). Co‐expression and pathway enrichment analysis revealed that genes related to Bcl2 were significantly enriched in the PI3K‐Akt signaling pathway, MAPK signaling pathway, and Wnt signaling pathway. Five cell clusters were identified in single‐cell RNA sequencing, and Bcl2 was mainly located in the mesenchyme.ConclusionThe rs3943258 located within BCL2 was probably related to NSCL/P susceptibility.
Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview
Authors: Tshikhudo Phumudzo P. , Mabhaudhi Tafadzwanashe , Koorbanally Neil A. , Mudau Fhatuwani N. , Avendaño Caceres Edgardo Oscar , Popa Dragos , Calina Daniela , Sharifi‐Rad Javad 
Published: December 2023

Abstracthis comprehensive review is designed to evaluate the anticancer properties of β‐carbolines derived from medicinal plants, with the ultimate goal of assessing their suitability and potential in cancer treatment, management, and prevention. An exhaustive literature survey was conducted on a wide array of β‐carbolines including, but not limited to, harmaline, harmine, harmicine, harman, harmol, harmalol, pinoline, tetrahydroharmine, tryptoline, cordysinin C, cordysinin D, norharmane, and perlolyrine. Various analytical techniques were employed to identify and screen these compounds, followed by a detailed analysis of their anticancer mechanisms. Natural β‐carbolines such as harmaline and harmine have shown promising inhibitory effects on the growth of cancer cells, as evidenced by multiple in vitro and in vivo studies. Synthetically derived β‐carbolines also displayed noteworthy anticancer, neuroprotective, and cognitive‐enhancing effects. The current body of research emphasizes the potential of β‐carbolines as a unique source of bioactive compounds for cancer treatment. The diverse range of β‐carbolines derived from medicinal plants can offer valuable insights into the development of new therapeutic strategies for cancer management and prevention.
Analysis and comparison of bioactive phytochemical composition and antibacterial property of two Ethiopian indigenous medicinal plants
Authors: Adamu Biruk Fentahun , Gao Jing , Xiangnan Yuan , Tan Shaojie , Song Ziyu , Xuexue Xiang 
Published: December 2023

AbstractIndigenous medicinal plants with naturally inherited antimicrobial properties are promising sources of antimicrobial agents. Two indigenous Ethiopian traditional medicinal plants (Rhamnus prinoide and Croton macrostachyus) extracted using different solvents and the yield percentage, phytochemical analysis and antimicrobial activity of the plant extracts were examined and compared. The results of this study revealed that Rhamnus prinoide leaf extract using aqueous methanol/ethanol (1 : 1) had the highest yield (15.12 %), a minimum inhibitory concentration of 0.625 mg/mL, and a minimum bactericidal concentration of 10 mg/mL against S. aureus. Croton macrostachyus leaves showed a yield of 14.7 ±0.37 %, a minimum inhibitory concentration of 40 mg/mL, and a minimum bactericidal concentration of 40 mg/mL against S. aureus and E. coli. GC‐MS analysis revealed that aqueous methanol/ethanol (1 : 1) of Rhamnus prinoide and Croton macrostachyus leaf extracts were composed of bioactive carbohydrates, flavonoid acid phenols, and terpenoids, while Croton macrostachyus extract contained primarily phytol (30.08 %). The presence of bioactive compounds confirms the traditional use of these plant leaves to treat various diseases, including wounds, leading to the conclusion that they could be applied to textiles for wound dressing in future studies.
Fetal diagnosis of meconium periorchitis: A case report
Authors: Moustafa Ahmed S. Z. , Araji Sarah 
Published: December 2023

Key Clinical MessageFetal meconium periorchitis (MPO) is rare prenatal diagnosis associated with meconium peritonitis. The prenatal ultrasound finding consists of an enlarged fetal scrotum with echogenic fluid and debris. In this report, we describe a case in which a prenatal diagnosis of MPO was accurately made at 32 weeks of gestation. The neonate delivered without complications, underwent immediate evaluation followed by major surgery, and ultimately had a favorable outcome. An accurate prenatal diagnosis is important to counsel the patient in a multidisciplinary approach. This case highlights the prenatal ultrasound findings as well as the neonatal presentation and the possibility for conservative management by pediatric urology.