bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical Carcinoid of the Lung with Brown Tumor of the Femur – A Case Report of a Rare Association
Authors: Zenezan Dina , Tushir Abhimanyu , Yin Jiejing , Arriola Aileen G , Proca Daniela 
Published: October 2023

Abstract
Background: A diagnosis of neuroendocrine tumor (NET) is challenging, but critical, bearing serious implications concerning treatment and prognosis.
Case Report: We describe a 39-year-old female presented with 2 weeks of increasing right leg pain preventing her from ambulating. She had a 6 month-long history of nausea, vomiting, and weight loss. Lab investigations showed hypercalcemia (13.1 mg/dl) and extremely elevated PTH (>2000 pg/ml). Differential diagnosis included primary hyperparathyroidism, as well as secondary hyperparathyroidism due to ectopic PTH production. Additional Imaging studies revealed a large lytic lesion in the femoral metaphysis and a well-circumscribed homogenous nodule in the right lower lobe. A lung biopsy showed a well-differentiated neuroendocrine neoplasm. Subsequently, right lower lobectomy was performed. The histologic and immuohistochemical features were consistent with a well differentiated neuroendocrine tumor, grade 2/3 (4.0 cm greatest dimension) with focal necrosis, and focally positive with Chromogranin, Synaptophysin and CD56, diffusely and strongly positive with AE1/AE3 and PTH, and negative with P-40, CDX2 and TTF1. A ki-67 showed approximately 15% nuclear positivity. Presence of necrosis, CDX2 negativity, and no involvement of other organs confirmed it as a primary lung neuroendocrine tumor with ectopic PTH secretion and secondary hyperparathyroidism.
Conclusion: This a very rare occurrence that raises awareness to the possible different etiologies of secondary hyperparathyroidism. Well-differentiated NETs are rare overall, while the hormone secreting NETs are very unusual.
Main Aspects of Pharmaceutical Development of In situ Immunobiological
Drugs for Intranasal Administration
Authors: Bakhrushina Elena , Mikhel Iosif , Kondratieva Valeriya , Demina Natalia , Grebennikova Tatyana , Krasnyuk Jr Ivan , Krasnyuk Ivan 
Published: October 2023

Introduction:
The review presents the latest developments in the area of intranasal in
situ delivery systems of immunobiological drugs (IBDs). Interest in intranasal administration for
IBDs has increased significantly due to the COVID-19 pandemic. However, not only intranasal
delivery of vaccines is developing, but also bacteriophages, interferons, etc. In situ systems that
make a selective phase transition can be a modern solution to intranasal delivery problems
caused by mucociliary clearance. In addition, smart-polymers used as the main excipients in in
situ systems can be used as specific adjuvants.

Methods:
A scientific search was conducted on the PubMed database of medical publications for
the period from 2000 to 2022, using the keywords "intranasal in situ vaccine"; "intranasal in situ
immunization". There were analyzed in detail more than 70 scientific studies on intranasal in situ
delivery of IBDs.

Results and Conclusions:
Despite the large number of new studies, the potential of possibilities
of intranasal in situ systems is not being realized. Based on the results of the literature review an
algorithm was created for the development of in situ systems for intranasal delivery of IBDs.
Such algorithms and the methods of study design organization described in the review will help
to facilitate the R&D process and bring the drug to commercial market, which will help to
improve the quality of medical care.
Interferon Signature’s Members, a Novel Altered Correlation upon
Interferon-β Treatment in Multiple Sclerosis Patients
Authors: Jabbari Sarvin , Hosseinpourfeizi Mohammadali , Safaralizadeh Reza , Baradaran Behzad 
Published: October 2023

Background:
Multiple sclerosis (MS) is a chronic inflammatory disease that
affects the central nervous system and is characterized by extensive brain damage
and neurodegeneration. Immunological, genetic, and histological analyses of MS
patients provide data in support of the concept that autoimmunity plays a crucial role in
the condition's course. It has been proposed that MS may be treated with interferon
(IFN)-β and other members of the type I family.

Objective:
Low levels of type I IFN in MS patients may affect immunological control,
establish the threshold for an IFN therapeutic response, and be "primed" or "fixed" by
IFN therapy.

Methods:
This study was conducted as a cross-sectional study. qRT-PCR was used
to examine the expression of two critical IFN regulatory genes, IFI44 and MX1, in MS
patients receiving IFN-β treatment.

Results:
The findings demonstrated a considerable rise in the expression of both
genes in MS patients treated with IFN-β compared to those newly diagnosed with the
illness. In addition, IFI44 and MX1 might be positively associated with their expression
after IFN-β therapy and be regarded as IFN-β responsiveness indicators.

Conclusion:
The IFI44/MX1 axis could act as one of the crucial regulators of the
disease following IFN-β treatment.
Analysis of Research Publications on Pharmacogenomics of Sulphonylurea
- A Scientometric Study
Authors: Thangaraju Pugazhenthan , Chandu Himanshu Nirmal , Velmurugan Hemasri , Kannauje Pankaj Kumar , Kumar R. Arun 
Published: October 2023

Abstract:
This study analysed pharmacogenomics studies on sulfonylurea research publications
using the Pubmed and Scopus databases. In the end, 65 publications from the years 2015 to
2021 were noticed. The objective of this study was to analyse these studies using scientometric
tools, such as frequency counts, percentages, relative growth rates, doubling times, and collectively. A maximum of 19 (29.23%) research publications were contributed during the 2020 research period. The relative growth rate tends to decrease from 2015 to 2020 and the doubling
time tends to increase and decrease after 2020. Up to 2 (3.08%) research publications were contributed by Ewan R. Pearson and Chen each. The top authors have an average degree of collaboration of 0.90 and 41 (63.83%) of their research publications are articles. The United States is
the major contributor with 19 (29.23%) pharmacogenomics research publications on sulfonylureas. Although the United States is the most prolific country in sulfonylurea pharmacogenomics
research, there are few Indian institutions that are not listed among the most prolific institutions
Value of Magnetic Resonance T1 Mapping in Evaluating the Early Response to
Treatment for Rheumatoid Arthritis
Authors: Dai Yi , Yuan Wenzhao , Chen Yidi , Lan Qiaoqing , Qin Fang , Ding Hao , Zhang Huiting , Lei Yiwu , Long Liling 
Published: October 2023

Background:
Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) is usually used for the semi-quantitative evaluation of joint changes in Rheumatoid arthritis (RA). But this method is slow in evaluating changes in bone marrow edema (BME).

Objective:
To determine whether T1 mapping of wrist bone marrow edema (BME) predicts early treatment response in rheumatoid arthritis (RA).

Methods:
This study prospectively enrolled 48 RA patients administered oral anti-rheumatic drugs. MRI of the most severely affected wrist was performed before and after 4 (48 patients) and 8 weeks of treatment (38 patients). Mean T1 values of BME in the lunate, triangular, and capitate bones; RAMRIS for each wrist; erythrocyte-sedimentation rate (ESR); and 28-joint Disease Activity Score (DAS28)-ESR score were analyzed. Patients were divided into responders (4 weeks, 30 patients; 8 weeks, 32 patients) and non-responders (4 weeks, 18 patients; 8 weeks, 6 patients), according to EULAR response criteria. Receiver operating characteristic (ROC) curves were used to evaluate the efficacy of T1 values.

Results:
ESR and DAS28-ESR were not correlated with T1 value and RAMRIS (P ＞ 0.05). Changes in T1 value and DAS28-ESR relative to the baseline were moderately positively correlated with each other at 4 and 8 weeks (r = 0.555 and 0.527, respectively; P ＜0.05). At 4 weeks, the change and rate of change in T1 value significantly differed between responders and non-responders (-85.63 vs. -19.92 ms; -12.89% vs. -2.81%; P ＜0.05). The optimal threshold of the rate of change in T1 value at 4 weeks for predicting treatment response was -5.32% (area under the ROC curve, 0.833; sensitivity, 0.900; specificity, 0.667).

Conclusion:
T1 mapping provides a new imaging method for monitoring RA lesions; changes in wrist BME T1 values reflect early treatment response.
2D QSAR Modelling, Docking, Synthesis and Evaluation of 2-substituted
Benzimidazole Derivatives as Anti-breast Cancer Agents
Authors: Ramachandran Surajambika Remya , Ramesh Barath , Ramesh Ruban , Venkatesan Jaitharasan 
Published: October 2023

Background:
Cancer is a leading cause of death worldwide and is anticipated to reach
28,4 million fresh cases globally by 2040. Despite all the progress made in cancer prevention,
diagnosis, and treatment, mortality by cancer is in second place.

Objectives:
The design of novel 2-substituted benzimidazole modelled by QSAR study. Molecular docking studies on the novel derivatives and synthesis characterization and evaluation of the
anticancer activity of the novel derivatives against breast cancer cell line MCF 7.

Methods:
We designed 10 novel benzimidazole derivatives modeled by 2D QSAR. From the ten
compounds by applying insilico tools of ADME properties and toxicity and through molecular
docking on Tyrosine Kinase (PDB ID: 2SRC). Compound 2AD showed the highest dock score of
-9.5 kcal/mol followed by 2 BD and 2GD (-9.3kcal/mol) Molecular dynamic simulation studies
were conducted using CABSflex an online molecular dynamic simulation tool. Six compounds
were selected for synthesis. The synthesized compounds were characterized and the invitro pharmacological activity was tested on MCF-7 cell line by MTT assay.

Results:
The compounds 2AD and 2GD showed good percentage inhibition on MCF-7 cell line
withIC50 values of 2.757 µg/ml and 2.875 µg/ml respectively.

Conclusion:
The novel 2-substituted benzimidazole derivatives are good lead compounds for
cancer therapy. Optimization of these compounds will be providing more target-specific
anticancer agents.
A Review on Emerging Impact of Antitubercular Activity of 1,2,4-Triazole
Derivatives
Authors: Rangaswamy Vedavathi , Laddi Umesh 
Published: October 2023

Abstract:
The present review aims to summarize the antitubercular profile of 1,2,4-triazole,
one of the emerging entitled and most sought scaffold with a wide spectrum of biological and
pharmacological activities. A systematic review of literature on ‘Heterocycles’, establishes
the fact that 1,2,4-triazoles and their derivatives exhibit diverse activities. The 1,2,4-triazole
core is found in therapeutically significant drugs and many new ones are in the pipeline. ‘Triazole pharmacophore’ has replaced the widely used ‘imidazole’ as ‘systemically integral azole’ by connecting synchronicity with serendipity. Triazoles are penetratingly studied as ‘diverse therapeutic agents’, due to the improved efficacy and reduced side effects. The extensive
anthology of work carried out in the last two decades on 1,2,4-triazole moiety will provide
imminent scope for the development of novel potential drugs having better efficacy selectivity
and reduced toxicity.
Review of Sacred Herbal Medicine Aegle marmelos: A Potent Metastasis
Inhibitor
Authors: Dhamne Sagarika , Agrawal Sneha A. 
Published: October 2023

Abstract:
Aegle marmelos (A. marmelos) appears to be a significantly used ayurvedic medicine.
This is a brilliantly composed nutritious fruit with carbohydrates, proteins, vitamins like riboflavin,
thiamine, niacin, fatty acids, and minerals. Scientific studies have proved that A. marmelos has
phytochemicals: carotenoids, phenolic, alkaloids, pectins, tannins, coumarins, flavonoids and terpenoids. Recent research on the effects of A. marmelos proved its anticancer, antimicrobial, cardioprotective, antidiabetic, and hepatoprotective activities. Extracts of various parts of plants such as
leaves, bark, stems, fruits, and pulp subjected to preclinical studies conducted on cell lines showed
apoptosis induction, inhibition of cell cycle and inhibition of proliferation of cells. Anti-cancer activity of A. marmelos was studied on selected cell lines of lung cancer, breast cancer, colon cancer
and leukaemia. A. marmelos reported significant inhibitory effect on cell proliferation in cell line
studies on A549, Ehrlich Ascites Carcinoma, MNU, DMBA, MCF-7, k562 cells, t-lymphoid Jurkat
cells, b lymphoid Raji cells, erythroleukemic Hel cells, melanoma Colo 38 cells which supports the
anticancer potential of it. Imperatorin has shown an antiproliferative effect on several cancer cell
lines. The hydroethanolic extract of A. marmelos leaves showed a decrease in cell viability on A549
Human lung cancer cell line which works by fold change over control of the β-Catenin-m RNA and
Wnt-mRNA expression of A549 and tumour growth suppression in DMBA induced carcinogenesis
in rats. In human promyelocytic leukaemia, HL-60 cells, imperatorin from A. marmelos has caused
cytochrome c-dependent apoptosis. Drugs interfere with the proliferative and survival signals that
suppress the growth of K562 cells by blocking BCR-ABL1. Proper awareness, development of
formulation and consumption of it make this drug scale up commercially.
Investigation of Antifungal Action of Fractions C17H31NO15 Isolated
from Artemisia herba-alba extract versus Isolated Aspergillus
niger from Zee maize
Authors: Amin Basma Hamdy , Ayyat Nahed Mohammed , Mohamed El-Sharkawy Reyad , Hafez Asmaa Mohamed 
Published: October 2023

Background:
Plants are harmed by parasitic organisms, and toxic poisons are
created. Phytopathogenic fungi create toxins that can severely harm plants' basic physiological
functioning.

Objective:
Investigation of antifungal impact of various fractions of methanol extract of
Artemisia herba-alba to Aspergillus niger as a plant pathogen.

Methods:
Artemisia herba-alba extract was purified using column chromatography, giving
various antifungal fractions tested versus A. niger.

Results:
The 6th fraction give the highest inhibition zone with a diameter of 5.4 cm and
MIC 125.02±4.9 μg/ml, which was identified using Mass spectroscopy, 1HNMR, Elemental
analysis as well as IR testing, revealing the chemical formula of the purified fraction.
Ultrastructure alteration of treated A. niger was examined versus control using the
transmission electron microscope. Purified fraction has tested versus normal cell line with
minimal cytotoxicity.

Conclusion:
These results revealed the possibility of using Artemisia herba-alba methanol
extract as a promising antifungal versus phytopathogenic fungi, especially A. niger after
more verification of results.
Estetik relevance Beksan Menak Sudarawerti Sertupelaeli towards character education
Authors: Herawati Enis Niken , Widyastutieningrum Sri Rochana , RM. Pramutomo RM. Pramutomo , Slamet Slamet 
Published: October 2023

Beksan Menak Sudarawreti Sirtupelaeli is a show that comes from the Javanese Palace. This dance is Yasan Dalem (creation) Sri Sultan Hamengkubuwaao IX. Beksan Menak Sudarawerti Sirtupelaeli is a performance that has a unique one of which lies in his dance moves.Revitalization of Estetik Beksan Menak Sudarawreti Sirtupelaeli to Develop Character Education is research with qualitative methods, namely by describing the Aesthetic Revitalization of Beksan Menak Sudarawreti Sirtupelaeli to Develop Character Education in detail. The study used primary and secondary data sources. The primary data source is the interview record. The researcher's secondary data sources were obtained through literature studies in the form of books, scientific journals that support research, and photo documentation of dance movement variations, Sudarawreti Sirtupelaeli kostrum. Data collection techniques are carried out with observation, interview, document study and literacy techniques.Understanding and knowing the aesthetics in the movement of Beksan Menak Sudarawreti Sirtupelaeli and knowing its relevance to character education is the purpose of this research. Based on the analysis of the data conducted, it was concluded that in the movement of Beksan Menak Sudarawreti Sirtupelaeli there are aesthetic values that contain meanings that are in accordance with the values of character education. Beksan Menak Sudarawreti Sirtupelaeli also has a relationship with the context of art and education as a guideline for daily life or values that contain noble ethics that are worth knowing. Keywords: Beksan Menak, Sudarawreti Sirtupelaeli, aesthetics, character education.
Development of virtual reality on material: Archimedes’ Law (VIRMA) to improve student learning outcomes
Authors: Prillyanti Dhanty Novya Bunga , Anggaryani Mita 
Published: October 2023

The development of this Virtual Reality (VR) with an artificial environment consisting of scenes and 3D objects is expected to be a problem solution from a low conceptual understanding of Archimedes' Law material. This study aims to make physics learning media with Virtual Reality on Archimedes' Law (VIRMA) material. The purpose of his research is to describe the validity of making Virtual Reality learning media on material: Archimedes' Law (VIRMA), to tell the effectiveness of making Virtual Reality learning media on material: Archimedes' Law (VIRMA) based on learning outcomes and student response questionnaires. The type of research used in this research is development research according to the ADDIE model with one group pre-test post-test research design. The result showed that the development of Virtual Reality media in Archimedes' Law (VIRMA) material is very valid, with a percentage value of 85.9%. Using Virtual Reality media on material: Archimedes' Law can provide hands-on learning experiences, facilitate a deeper understanding of abstract concepts, and improve student learning outcomes with n-gain in the medium category 0,67. In addition, the response questionnaire showed that 93.7% of students agreed that Virtual Reality media was enjoyable and effective in helping to understand Archimedes' Law. Using the Virtual Reality media on the material is recommended: Archimedes' Law, which can increase student involvement, stimulate student interest in learning physics, and improve student learning outcomes.
The relationship between zonulin level and indicators of carbohydrate metabolism in patients with metabolic-associated fatty liver disease combined with type 2 diabetes mellitus
Authors: Didyk O.K. , Chernyavskyi V.V. , Shypulin V.P. 
Published: October 2023

Background. The purpose of the study was to determine the relationship between serum zonulin level and indicators of carbohydrate metabolism in patients with metabolic-associated fatty liver disease (MAFLD) combined with type 2 diabetes mellitus (DM). Materials and methods. The study involved 78 patients with MAFLD and type 2 DM, who were examined and divided into 2 groups. The first group consisted of 42 patients with МAFLD and type 2 DM without small intestinal bacterial overgrowth (SIBO). The second group included 36 patients with МAFLD and type 2 DM in combination with SIBO. The control group consisted of 20 practically healthy persons. The content of serum zonulin was determined by the enzyme-linked immunosorbent assay (ELISA) using the IDK Zonulin ELISA test systems, KR5601 (Immundiagnostik AG, Germany). Results. The study of the content of serum zonulin revealed its significant increase in patients with MAFLD combined with type 2 DM without SIBO — (70.78 ± 2.09) ng/ml and with SIBO — (82.64 ± 2.71) ng/ml compared to the control group — (13.26 ± 1.53) ng/ml (p < 0.001). When comparing the parameters of carbohydrate metabolism, a significant increase was found in fasting blood glucose — (10.25 ± 0.30) mmol/l and (10.43 ± 0.33) mmol/l, insulin — (22.66 ± 0.64 mU/l) and (22.96 ± 0.70) mU/l, НOMA-IR — 10.4 ± 0.4 and 10.87 ± 0.66, HbA1c — 8.89 (8.03–9.95) % and 8.61 (8.02–10.34) %, C-peptide — (5.44 ± 0.06) ng/ml and (5.95 ± 0.10) ng/ml in patients with MAFLD combined with type 2 diabetes without and with SIBO, respectively, as compared to the control group (p < 0.001). Indicators of fasting plasma glucose, insulin, HbA1c and the НOMA-IR in patients of the first and second groups did not differ significantly (p > 0.05), and the level of C-peptide was increased significantly in patients of the second group compared to the first one (p < 0.001). Correlation analysis between serum zonulin level and indicators of carbohydrate metabolism in patients with MAFLD combined with type 2 DM without and with SIBO found a moderate positive correlation with levels of glucose, insulin and HOMA-IR, and a weak correlation was found between serum zonulin level with HbA1c and C-peptide. Conclusions. An increase in serum zonulin was found in patients with MAFLD combined with type 2 DM without and with SIBO, which indicated an increase in the intestinal permeability. The content of serum zonulin was associated with hyperglycemia and hyperinsulinemia. Thus, impaired intestinal permeability is pathogenetically associated with the development of insulin resistance.
Simple Thermal Analysis as a Green Method for the Detection of Meat Adulteration
Authors: Nugrahani Ilma , Aditya Aditya 
Published: October 2023

Differential scanning calorimetry (DSC) is one of the most widely developed thermal analysis methods for meat samples for halal authentication of food or processed products. Research on adulteration detection for various types of meat and its derivatives has been developed before and still requires organic solvents. Therefore, the concept of the "green method" is being tried to develop in this research. DSC analyses are performed in the same experimental conditions for all sample powder: sample mass 2 mg, temperature range 30–400 °C, and heating rate 20 °C min−1. The results showed there is a characteristic minor endothermic peak for each meat. Chemometric analysis was carried out using the principal component analysis (PCA) method to ensure that the thermal characteristics of each meat were utterly different in both pure and mixed meat. The results of this analysis indicate that each pure meat has a different score plot. Therefore, the developed thermal analysis method is quite reliable in determining the different types of meat based on the characteristic minor endothermic peak in the thermogram and the score plot from PCA analysis.
Spiritual and Knowledge level, and the Acceptance of Patients with Chronic Renal Failure Who Underwent Hemodialysis
Authors: Permana Iman 
Published: October 2023

Background: Spirituality and knowledge level has been correlated to the patient's adaptive ability to accept the condition among chronic renal failure (CRF) patients undergoing hemodialysis. Objective: To determine the relationship between the spiritual and knowledge level towards the acceptance of hemodialysis among patients in PKU Muhammadiyah Yogyakarta. Method: an analytic cross-sectional study was conducted on 101 patients who underwent hemodialysis. Data collection was done utilizing the Daily Spiritual Experience Scale (DSES) questionnaire, knowledge level of hemodialysis, and Illness Cognition Questionnaire (ICQ). The Spearman correlation test and multiple linear regression test were used to analyze the results. Results: The majority of patients have a high spiritual level, level of knowledge, and acceptance. There is a significant relationship between the spiritual level and knowledge level on the acceptance of CRF patients undergoing hemodialysis with a p-value of 0.000. Linear multiple regression analysis shows that the spiritual level has more influence on acceptance than other factors with a beta value of 0.550. Conclusion: Spiritual and knowledge levels might influence the acceptance of CRF patients undergoing hemodialysis. However, the spiritual level is the most influencing factor on acceptance. Dialysis nurses are advised to improve their ability to provide spiritual nursing care and promoting better knowledge to patients undergoing hemodialysis.