bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbandingan Harga Opsi Saham Tipe Eropa Menggunakan Model Black Scholes dan Black Scholes Fraksional
Authors: Rusmaningtyas Rahmanita Febrianti , Satyahadewi Neva , Rizki Setyo Wira 
Published: October 2023

One of the investment is stocks. Stocks have derivative instrument in the form of stock options. Stocks option is a contract between two parties in the form of the right to sell and buy a stocks at a certain price and time. The method used in this study is the fractional Black Scholes and Black Scholes method with time of maturity fractioned by the Hurst parameter. The purpose od this study is to compare the prices of call and put options using the Black Scholes and Fractional Back Scholes. The data using close price of Apple Inc shares within period between October 1st 2020 until September 30th 2021. If the market option price is greater than the theoretical price using the Black Scholes or Fractional Black Scholes model, then the option is recommended to be sold and if the market option price is lower, the option is recommended to be purchased. Based on the smallest MAPE, the best model for call options is Fractional Black Scholes with Hurst Parameter 0,4 with 0,383% which means it is very accurate and the best model for put options is the Fractional Black Scholes Model with Hurst parameter 0,9 with 16,055% whick means accurate.Keywords: Black Scholes Fractional, Hurst Parameter, Stock Option. AbstrakSalah satu instrumen dalam berinvestasi adalah saham. Saham memiliki instrumen derivatif berupa opsi saham. Opsi saham adalah suatu pemberian kontrak antara dua pihak berupa hak untuk menjual dan membeli suatu saham dengan harga dan waktu tertentu. Harga opsi tipe Eropa dapat ditentukan dengan model Black Scholes dan Black Scholes Fraksional dengan waktu jatuh tempo yang difraksional menggunakan parameter Hurst. Penelitian ini bertujuan untuk membandingkan harga opsi beli dan opsi jual dengan model Black Scholes dan Black Scholes Fraksional. Data yang digunakan adalah harga penutupan saham Apple Inc periode 1 Oktober 2020 sampai 30 September 2021. Langkah dalam menghitung harga opsi adalah menghitung return saham, uji normalitas, menghitung volatilitas, menentukan parameter, menghitung harga opsi beli dan opsi jual, menghitung nilai MAPE dan melakukan perbandingan kedua model. Jika harga opsi pasar lebih besar daripada harga opsi teoritis menggunakan model Black Scholes atau Black Scholes Fraksional maka opsi direkomedasikan untuk dijual dan jika harga opsi pasar lebih kecil maka opsi direkomendasikan untuk dibeli. Berdasarkan nilai MAPE terkecil model terbaik untuk opsi beli saham adalah Black Scholes Fraksional dengan Parameter Hurst 0,4 dengan MAPE sebesar 0,383% yang berarti sangat akurat dan untuk opsi jual saham adalah Model Black Scholes Fraksional dengan parameter Hurst 0,9 dengan MAPE sebesar 16,055% yang berarti akurat.
Implementasi Metode Polinomial Newton Gregory untuk Mengestimasi Produksi Tanaman Biofarmaka di Kalimantan Barat
Authors: Almira Zada , Yundari Yundari , Im’roah Nurfitri 
Published: October 2023

Biopharmaceutical plants or known as medicinal plants are types of plants that have functions and efficacious as medicines and are used to cure or prevent various diseases. Empirically, the use of biopharmaceutical plants is believed to be efficacious and passed on as a cultural wealth from generation to generation through tradition. Previous research has shown that some people in West Kalimantan still use biopharmaceutical plants as an alternative to traditional medicine. So, there needs to be an estimate of the number of production biopharmaceutical plants in West Kalimantan using Newton Gregory Polynomial Interpolation. Methode of The Newton Gregory Polynomial has two types, namely Forward Newton Gregory Polynomial and Backward Newton Gregory Polynomial. The accuracy of the two methods can be seen from the results of the relative error analysis. The simulation with the Newton Gregory Backward Polynomial, the average of relative error is 0,5338, while the implementation with the Newton Gregory Forward Polynomial, the average of relative error is 0,6569.Keywords: Newton Gregory Polynomial, Newton Gregory Polynomial, Mean Relative Error. AbstrakTanaman biofarmaka atau dikenal dengan nama tanaman obat adalah jenis-jenis tanaman yang memiliki khasiat sebagai obat dan dipergunakan untuk penyembuhan ataupun mencegah berbagai penyakit. Pemanfaatan tanaman biofarmaka secara empiris diyakini kemanjurannya dan diwariskan sebagai kekayaan budaya turun melalui tradisi. Penelitian terlebih dahulu membuktikan bahwa sebagian masyarakat di Kalimantan Barat masih menggunakan tanaman biofarmaka sebagai alternative pengobatan tradisional. Maka dari itu diperlukan adanya pengestimasian jumlah produksi tanaman biofarmaka Provinsi Kalimantan Barat menggunakan Interpolasi Polinomial Newton Gregory. Interpolasi Polinomial Newton Gregory memiliki dua jenis, yaitu Polinomial Newton Gregory Maju dan Polinomial Newton Gregory Mundur. Hasil simulasi estimasi menunjukkan bahwa Polinomial Newton Gregory Mundur, diperoleh rata-rata galat relatif sebesar 0,5338, Sedangkan implementasi dengan menggunakan Polinomial Newton Gregory Maju diperoleh rata-rata galat relatif 0,6569.
Analisis Kestabilan Pemodelan Matematika Penyebaran COVID-19 dengan Adanya Individu Carrier dan Pengaruh Isolasi di DKI Jakarta
Authors: Disviana Sarah , Wiraningsih Eti Dwi , Hadi Ibnu 
Published: October 2023

In this research, a mathematic model which describe Covid-19 spreading in DKI Jakarta is constructed. The model consists of susceptible compartment, symptomatic infection comparte- ment, asymptomatic infection compartement, self isolation compartement, isolation at hospital compartement and recover compartement. Next, the disease free stability point will be analyzed to know the stability and simulation wiil be carried out with the help of maple software and octave on the model that has been formed. After doing the simulation using Covid-19 data in Jakarta until July 5th, 2021, the value of basic reproduction number is 0, 04152673249 which means that basic reproduction value less than one. This shows the spread of Covid-19 will slowly disappear.Keywords: Basic Reproduction Number, Covid-19, Mathematic Modelling, Stability.AbstrakDalam penelitian ini, dibentuk model matematika yang menggambarkan penyebaran COVID-19 di DKI Jakarta yang terdiri atas kompartemen rentan, kompartemen terin- feksi bergejala, kompartemen terinfeksi tidak bergejala, kompartemen isolasi di rumah, kompartemen isolasi di rumah sakit dan kompartemen sembuh. Selanjutnya, akan dianalisis titik kesetimbangan bebas penyakit untuk mengetahui kestabilannya dan akan dilakukan simulasi dengan bantuan maple software dan octave. pada model yang su- dah dibentuk. Setelah dilakukan simulasi dengan menggunakan data COVID-19 di DKI Jakarta sampai tanggal 5 Juli 2021, dihasilkan nilai angka reproduksi dasar sebesar 0, 04152673249 yang berarti bahwa angka reproduksi dasar kurang dari satu. Hal ini menunjukkan penyebaran COVID-19 secara perlahan akan menghilang.
Engineering und Inbetriebnahme von Produktionsanlagen
Authors: Schleipen Miriam , Mersch Tina , Karch Sabrina 
Published: October 2023

Um den gewachsenen Anforderungen an Individualität, Flexibilität und Effizienz in der Produktion gerecht zu werden, müssen Anlagenbauer (nicht nur aus dem Automotive-Bereich) ihren Engineering- und Inbetriebnahmeprozess radikal vereinfachen. Eine effektive und durchgängige Digitalisierung des Datenaustauschs über den gesamten Lebenszyklus einer Anlage ermöglicht eine optimale Zusammenarbeit zwischen den beteiligten Akteuren und ist daher ein großer Optimierungs-Hebel. Das Projekt DIAMOND hat sich ein gemeinsames, vernetztes, domänenübergreifendes Datenmodell zum Ziel gesetzt, das in der Industrie mit den dort vorherrschenden Anforderungen nutzbar ist. Hierfür müssen alle beteiligten Prozessschritte, Akteure, Tools, Datenformate und ausgetauschte Informationen im Detail analysiert werden. Die Ergebnisse dieser Analyse werden in diesem Beitrag von den Autoren vorgestellt.
Sociedad civil y políticas de rendición de cuentas
Authors: Fox Jonathan 
Published: October 2023

La influencia de la sociedad civil sobre la rendición de cuentas pública se reconoce ampliamente. Sin embargo, los patrones específicos y los mecanismos causales de su impacto no han sido suficientemente determinados. Este artículo presenta algunas de las elecciones conceptuales explícitas, ineludibles para definir la rendición de cuentas, distinguiendo entre la institucionalmente acotada “rendición de cuentas política” por un lado, y la más amplia y multi–dimensional “política de la rendición de cuentas”, por el otro. Con el propósito de identificar las trayectorias de influencia de la sociedad civil sobre el Estado, este artículo propone desglosar las relaciones de rendición de cuentas entre los actores del Estado y la sociedad civil, abordarlas desde dentro de ellos y, finalmente, evitar un tratamiento aislado como si cada instancia fuera implícitamente monolítica. A la vez, es necesario expandir los marcos conceptuales de la rendición de cuentas, de manera que permitan comprender la interacción entre los ámbitos locales, nacionales e internacionales. La discusión tiene como punto de partida la diferenciación entre las dimensiones vertical y horizontal de la rendición de cuentas, y enfatiza la interdependencia e interacciónque se da entre ellas.
Economics of Rubber Plantation in Mokokchung District
Authors: Longkumer Watisenla , Sharma Amod 
Published: October 2023

Background: The present study was conducted with an aim to study the socio-economic and livelihood of the rubber growers in Mokokchung district, further main objective is to provide extra income as well as generating more employment through rubber plantation. Methods: For the present research study a total of 160 respondents were selected from 8 villages, out of which, 94 respondents (58.75 per cent) were small, 50 respondents (31.25 per cent) were marginal and 16 respondents (8.00 per cent) were medium farms, respectively. Result: Gross income for marginal, small and medium farmers was ₹ 2,48,400, ₹ 6,21,000 and ₹ 9,93,600 and net income was ₹ 95,300, ₹ 4,10,797.88 and ₹ 7,46,600. About 52.50 per cent respondents were employed in government sector with an average annual income of ₹ 1,01,70,021, followed by 38.75 per cent respondents with an average annual income of ₹ 31,00,016, 5 per cent respondents were daily wage earners with an average annual income of ₹ 2,10,002 and 3.75 per cent respondents were working in private sectors with an annual income of ₹ 5,40,000. Maximum required trained labourers and hired labourers, 89.00 per cent had permanent workers and 29.00 per cent had contract labourers. Total two marketing channels were involved viz; channel I: Producer-Processor, channel II: Producer-Agent-Processor. In channel I, the marketing cost incurred by the producer was ₹ 38/kg and the marketing cost incurred by the agent was ₹ 27/kg. In channel II the marketinpg cost incurred by the producer was ₹ 3/kg and the marketing cost incurred by the agent was ₹ 36/kg. The major cconstraints were lack of local trained labourers, lack of government funding, lack of market, price instability, lack of training programmes and road condition.
Ecologia intertextual, imagens rurais e metapoesia nas "Heroides", de Ovídio
Authors: Avellar Júlia Batista Castilho de 
Published: October 2023

As Heroides, de Ovídio, foram frequentemente interpretadas em termos de mescla de gêneros, conferindo-se especial destaque para a mistura dos gêneros epistolar e elegíaco, com a incorporação também de elementos da retórica. Este trabalho analisa passagens da obra em que são explorados temas, vocabulário e imagens rurais, a fim de investigar a presença nas cartas das heroínas de elementos característicos da poesia didática antiga. Assim, com base nas relações entre natureza e literatura, investigo nas quinze primeiras epístolas das Heroides a ocorrência de símiles, metáforas e descrições envolvendo o ambiente e as atividades rurais (como a agricultura, a caça e a criação de animais). Com isso, busco discutir as significações que tais imagens rurais conferem à obra e colocar em realce os diálogos possíveis com a tradição didática antiga, especialmente com as Geórgicas, de Virgílio.
Impact of Hydrocarbon Emissions from Oil and Gas Deposits on δ13С Variability in Pine Tree Rings
Authors: Churakova (Sidorova) Olga V. , Batalin Georgy , Gareev Bulat , Mingazov Gazinur , Terekhin Andrey , Tishin Denis , Kuzina Dilyara , Nurgaliev Danis 
Published: October 2023

Human-caused anthropogenic greenhouse emissions impact climate globally. In this pilot study, we aim to reveal the impact of oil and gas emissions from local oil deposits in the regime of their natural degradation and development and eco-physiological changes of pine forests in Tatarstan Republic, Russia over the past century.
We performed stable carbon isotope analysis in pine tree rings (13Cptrw) to reveal the impact of oil and gas emissions from the giant oil field reservoirs located in Leninogorsk region (UVRT) and the natural reserve site in Raifa.
Our results show decreasing 13Cptrw at UVRT in 1943 when oil extraction was started, and in 1970, when it reached the maximum production. We found that 13Cptrw from UVRT indicates on developing unfavourable drier conditions and suppressed tree growth caused by both human-induced oil and deposit infrastructure and natural processes compared to undisturbed Raifa. The 13Cptrw from Raifa is more negative compared to UVRT, which can be explained by higher forest sensitivity to human-induced impact. From an ecophysiological point of view decreasing intercellular to ambient CO2 concentration at the leaf level and increasing intrinsic water use efficiency along with decreasing tree-ring width at UVRT (1970-2021) indicate on development of drought conditions.
Treatment characteristics of patients with hereditary transthyretin amyloidosis: a cohort study
Authors: Qarni Taha , Jones Felipe J.S. , Drachman Brian , Khella Sami , Pieretti Janice , Bustamante Nicolas Sarmiento , Karam Chafic 
Published: October 2023

Abstract

Background
There are novel medications approved for the treatment of hereditary transthyretin amyloidosis (ATTRv), classified as transthyretin (TTR) stabilizers or gene silencers. While many patients may be on both classes of medications, there is no data available on the safety and efficacy of combination therapy.
Objectives
To describe ATTRv patient and TTR-targeted therapy characteristics in a US cohort, and compare outcomes with combination therapy versus monotherapy.
Methods
We performed a retrospective cohort study with electronic health record data of patients with ATTRv seen at a single institution between January 2018 and December 2022. We collected data on symptomatology, gene mutation, disease severity, ATTRv treatment, hospitalizations, and mortality.
Results
162 patients with ATTRv were identified. The average age at diagnosis was 65 years. 86 patients (53%) had the V122I variant. 119 patients were symptomatic, of whom 103 were started on ATTRv-specific treatment. 41 patients (40%) had cardiomyopathy only, and 53 (51%) had a mixed phenotype of cardiomyopathy and neuropathy. 38 patients (37%) received therapy with both a gene silencer and protein stabilizer. 9 patients (15%) in the monotherapy group had two or more cardiac hospitalizations after starting treatment, compared to 3 patients (9%) on combination therapy (p = 0.26). The adjusted hazard ratio of all-cause mortality for the patients on combination therapy compared to monotherapy was 0.37 (0.08–1.8, p = 0.21).
Conclusions
While the efficacy is unproven, over one-third of patients with ATTRv are on both a stabilizer and a silencer. There were no safety issues for combination therapy. There was a trend towards improved hospitalizations and survival in patients in the combination group but this was not statistically significant. Larger studies with longer follow-up are necessary to determine benefit of combination therapy.
Early Resistance Rehabilitation Improves Functional Regeneration Following Segmental Bone Defect Injury
Authors: Guldberg Robert , Williams Kylie , Harrer Julia , LaBelle Steven , Leguineche Kelly , Kaiser Jarred , Karipott Salil , Lin Angela , Vongphachanh Alyssa , Fulton Travis , Rosenthal J , Muhib Farhan , Ong Keat , Weiss Jeffrey , Willett Nick 
Published: October 2023

Abstract

Mechanical loading is integral to bone development and repair. The application of mechanical loads through rehabilitation are regularly prescribed as a clinical aide following severe bone injuries. However, current rehabilitation regimens typically involve long periods of non-loading and rely on subjective patient feedback, leading to muscle atrophy and soft tissue fibrosis. While many pre-clinical studies have focused on unloading, ambulatory loading, or direct mechanical compression, rehabilitation intensity and its impact on the local strain environment and subsequent bone healing have largely not been investigated. This study combines implantable strain sensors and subject-specific finite element models in a pre-clinical rodent model with a defect size on the cusp of critically-sized. Animals were enrolled in either high or low intensity rehabilitation one week post injury to investigate how rehabilitation intensity affects the local mechanical environment and subsequent functional bone regeneration. The high intensity rehabilitation animals were given free access to running wheels with resistance, which increased local strains within the regenerative niche by an average of 44% compared to the low intensity (no-resistance) group. Finite element modeling demonstrated that resistance rehabilitation significantly increased compressive strain by a factor of 2.0 at week 1 and 4.45 after 4 weeks of rehabilitation. The resistance rehabilitation group had significantly increased regenerated bone volume and higher bone bridging rates than its sedentary counterpart (bone volume: 22.00 mm3 ± 4.26 resistance rehabilitation vs 8.00 mm3 ± 2.27 sedentary; bridging rates: 90% resistance rehabilitation vs 50% sedentary). In addition, animals that underwent resistance running had femurs with improved mechanical properties compared to those left in sedentary conditions, with failure torque and torsional stiffness values matching their contralateral, intact femurs (stiffness: 0.036 Nm/deg ± 0.006 resistance rehabilitation vs 0.008 Nm/deg ± 0.006 sedentary). Running on a wheel with no resistance rehabilitation also increased bridging rates (100% no resistance rehabilitation vs 50% sedentary). Analysis of bone volume and von Frey suggest no-resistance rehabilitation may improve bone regeneration and hindlimb functionality. These results demonstrate the potential for early resistance rehabilitation as a rehabilitation regimen to improve bone regeneration and functional recovery.
High bile titer and high bile to serum ratio of CYFRA 21-1 reliably discriminate malignant biliary obstruction caused by cholangiocarcinoma
Authors: Chen Jiancong , Liang Jiahua , Xu Borui , Liang Jianbo , Ma Mingjian , Wang Zicheng , Zeng Guangyan , Xu Qiongcong , Liang Lijian , Lai Jiaming , Huang Li 
Published: October 2023

Abstract

Introduction
Previously we demonstrated that elevated serum CYFRA 21 − 1 is a reliable diagnostic and prognostic biomarker for biliary tract cancers. This study aims to explore the diagnostic performance of bile CYFRA 21 − 1 (bCYFRA 21 − 1) in discriminating malignant biliary obstruction (MBO) caused by cholangiocarcinoma (CCA).
Methods
77 CCA patients ((17 intrahepatic CCA (iCCA), 49 perihilar CCA (pCCA) and 11 distal CCA (dCCA)) and 43 benign patients with MBO were enrolled. Serum and bile levels of CYFRA 21 − 1, carcinoembryonic antigen (CEA) and carbohydrate antigen 19 − 9 (CA19-9) were quantified. Diagnostic performances of these biomarkers were estimated by receiver operator characteristic curves. Subgroups analysis of these tumor markers among CCA subtypes was performed.
Results
High bCYFRA 21 − 1 (cut-off value of 59.25 ng/mL with sensitivity of 0.889 and specificity of 0.750) and high bile to serum ratio of CYFRA 21 − 1 (b/sCYFRA 21 − 1, cut-off value of 31.55 with sensitivity of 0.741 and specificity of 0.778) achieved better diagnostic performance than any other biomarker in discriminating MBO. Subgroup analysis revealed that bCYFRA 21 − 1 was significantly elevated in all CCA subtypes; moreover b/sCYFRA 21 − 1 was upregulated in pCCA and dCCA (the mean b/sCYFRA 21 − 1 of pCCA was highest among CCA subtypes: 57.90, IQR 29.82-112.27).
Conclusions
Both high bCYFRA 21 − 1 and high b/sCYFRA 21 − 1 were reliable diagnostic biomarkers for MBO caused by CCA.
M6A methylase related MCM3AP-AS1 promotes the progression of colorectal cancer through the miR-98/IGF2BP1 signaling axis
Authors: Ma Wenhui , Ren Mudan , He Shuixiang , Guo Meng , Jing Du , Ran Shuang , Li Hangwei 
Published: October 2023

Abstract

Background
To investigate the relationship between N6-methyladenosine (m6A) related Long non-coding RNAs (lncRNAs) and prognosis in colon cancer (COAD) patients, and the effect of M6A methyltransferase RBM15 on downstream genes regulated by MCM3AP-AS1.
Methods
Download gene expression and clinical data from 552 COAD samples and 44 adjacent cancer samples from TCGA. Use the DESeq2 software package to screen differentially expressed genes (DEG) between COAD and adjacent cancer tissues. Calculate the correlation between m6A related genes and lncRNAs to screen for m6A related lncRNAs. Univariate Cox regression analysis is used to screen for m6A related lncRNAs that are significantly correlated with prognosis. Subsequently, LASSO was used to screen key lncRNAs from prognosis related lncRNAs to construct a risk model. CCK-8, Wound healing assay, Transwell assay, Flow cytometry, FISH assay, RNA pull-down, Double Luciferase activity assay and rescue experiment were used to explore the effect of MCM3AP-AS1 on colorectal cancer and its specific mechanism.
Results
Bioinformatics analysis constructed a risk model consisting of 12 lncRNAs. The prognosis of patients in the high-risk group is significantly lower than that in the low-risk group. The risk score has been proven to be an independent prognostic factor for COAD. Subsequently, a ceRNA network consisting of 8 m6A related lncRNAs, 23 miRNAs, and 1531 mRNA was established. Cell experiments have confirmed that the M6A methyltransferase RBM15 is significantly upregulated in colorectal cancer cells, which can mediate the regulation of miR-98 expression by MCM3AP-AS1. MCM3AP-AS1 is significantly upregulated in colorectal cancer cells, promoting cell proliferation, migration, invasion, and inhibiting cell apoptosis. The specific molecular mechanism may be to regulate the expression of IGF2BP1 by targeting downstream miR-98.
Conclusion
MCM3AP-AS1 can target miR-98 to regulate the expression of IGF2BP1, which may be a potential mechanism for the occurrence and development of colorectal cancer.