bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decoupling power and type I error rate considerations when incorporating historical control data using a test‐then‐pool approach
Authors: Okada Kazufumi , Tanaka Shiro , Matsubayashi Jun , Takahashi Keita , Yokota Isao 
Published: January 2024

AbstractTo accelerate a randomized controlled trial, historical control data may be used after ensuring little heterogeneity between the historical and current trials. The test‐then‐pool approach is a simple frequentist borrowing method that assesses the similarity between historical and current control data using a two‐sided test. A limitation of the conventional test‐then‐pool method is the inability to control the type I error rate and power for the primary hypothesis separately and flexibly for heterogeneity between trials. This is because the two‐sided test focuses on the absolute value of the mean difference between the historical and current controls. In this paper, we propose a new test‐then‐pool method that splits the two‐sided hypothesis of the conventional method into two one‐sided hypotheses. Testing each one‐sided hypothesis with different significance levels allows for the separate control of the type I error rate and power for heterogeneity between trials. We also propose a significance‐level selection approach based on the maximum type I error rate and the minimum power. The proposed method prevented a decrease in power even when there was heterogeneity between trials while controlling type I error at a maximum tolerable type I error rate larger than the targeted type I error rate. The application of depression trial data and hypothetical trial data further supported the usefulness of the proposed method.
Nano‐bio interactions between 2D nanomaterials and mononuclear phagocyte system cells
Authors: Zhao Jing , Chen Zheng , Liu Shanbiao , Li Pin , Yu Shiyi , Ling Daishun , Li Fangyuan 
Published: January 2024

AbstractTwo‐dimensional (2D) nanomaterials, known for their unique atomic arrangements and exceptional physicochemical properties, have garnered significant attention in biomedical applications, particularly in the realms of immunotherapy for tissue engineering and tumor therapy. These applications necessitate a thorough assessment of the potential influence of 2D nanomaterials on immune cells. Notably, the mononuclear phagocyte system (MPS) cells, which play pivotal roles in both innate and adaptive immunity, are essential for maintaining organismal homeostasis. MPS cells with phagocytic capability contribute to the prevention of foreign body invasion and the elimination of dead or senescent cells. Furthermore, MPS cells, including macrophages and dendritic cells, serve as vital bridges between innate and adaptive immune responses. Therefore, understanding the nano‐bio interactions between 2D nanomaterials and MPS cells is imperative. These nano‐bio interactions including cellular uptake, cytocompatibility, and immunological impact are invaluable for the purposeful design of 2D nanomaterials. Herein, we provide an overview of the latest advancements in understanding the nano‐bio interactions between 2D nanomaterials and MPS cells, and discuss the current challenges and future prospects of employing 2D nanomaterials in the field of nanomedicine.
Impact of the COVID‐19 pandemic on the in‐hospital diagnostic pathway of breast and colorectal cancer in the Netherlands: A population‐based study
Authors: Wolfkamp Wouter , Meijer Joyce , van Hoeve Jolanda C. , van Erning Felice , de Geus‐Oei Lioe‐Fee , de Hingh Ignace , Veltman Jeroen , Siesling Sabine ,   the COVID and Cancer‐NL Consortium
Published: January 2024

AbstractBackgroundIn the Netherlands, the COVID‐19 pandemic resulted in a temporary halt of population screening for cancer and limited hospital capacity for non‐COVID care. We aimed to investigate the impact of the pandemic on the in‐hospital diagnostic pathway of breast cancer (BC) and colorectal cancer (CRC).Methods71,159 BC and 48,900 CRC patients were selected from the Netherlands Cancer Registry. Patients, diagnosed between January 2020 and July 2021, were divided into six periods and compared to the average of patients diagnosed in the same periods in 2017–2019. Diagnostic procedures performed were analysed using logistic regression. Lead time of the diagnostic pathway was analysed using Cox regression. Analyses were stratified for cancer type and corrected for age, sex (only CRC), stage and region.ResultsFor BC, less mammograms were performed during the first recovery period in 2020. More PET‐CTs were performed during the first peak, first recovery and third peak period. For CRC, less ultrasounds and more CT scans and MRIs were performed during the first peak. Lead time decreased the most during the first peak by 2 days (BC) and 8 days (CRC). Significantly fewer patients, mainly in lower stages, were diagnosed with BC (−47%) and CRC (−36%) during the first peak.ConclusionSignificant impact of the COVID‐19 pandemic was found on the diagnostic pathway, mainly during the first peak. In 2021, care returned to the same standards as before the pandemic. Long‐term effects on patient outcomes are not known yet and will be the subject of future research.
The homologous tumor‐derived‐exosomes loaded with miR‐1270 selectively enhanced the suppression effect for colorectal cancer cells
Authors: Jin Yingmin , Sun Liying , Chen Yingying , Lu Yue 
Published: January 2024

AbstractBackgroundColorectal cancer (CRC), known as prevalent cancer, has risen to be the leading cause of cancer‐related death. Engineered exosomes had attracted much attention since they acted as carriers to deliver small molecule drugs, therapeutic nucleic acids, and polypeptides to treat a series of cancers.Methods and ResultsHere, we found that the PKH‐26 labeled exosomes, which were derived from the CRC cells, could be efficiently absorbed by SW1116 cells and had an abundant fluorescence distribution in tumors, compared with the exosomes derived from mesenchymal stem cells (MSC) and HepG2 cells. This Research demonstrated that engineered CRC‐exosomes loaded with functional miR‐1270 (Exo‐miR‐1270) enriched in miR‐1270 strongly inhibited the proliferation by CCK‐8 and EdU assays, migration by wound‐healing and transwell assays, and promoted the apoptosis for CRC cells through flow cytometry. MiR‐1270 overexpression delivered by CRC exosomes contributed to inhibiting the tumor growth potential of CRC in vivo and increasing the overall survival of the mice. Moreover, the safety evaluation results showed that CRC‐exosomes loaded with functional miR‐1270‐mimics had no toxicity for other organs by histopathological analysis and no influence on the vital chemistry and hematology parameters for mice in vivo safety evaluation.ConclusionThese results indicate that Exo‐miR‐1270 can effectively treat CRC tumors by intravenous administration. Our work provided a foundation that the homologous tumor‐derived exosomes mediated miRNA delivery for the treatment of CRC.
Exploring the Fluconazole‐Resistance Modifying Activity and Potential Mechanism of Action of Fixed Oil from Caryocar coriaceum Wittm. (Caryocaraceae) against Candida Species
Authors: Almeida‐Bezerra José Weverton , Pereira da Cruz Rafael , Bezerra da Silva Viviane , Da Silva Neto João Xavier , Alves Lopes de Souza Larissa , de Oliveira Bezerra de Sousa Daniele , Monteiro Salgueiro Araujo Nadine , Guimarães Gomes Silva Rafael , Quefi Blasco , Rau Martinho , Andrade Rebelo Ricardo , Castro dos Santos Sarah , Everson da Silva Luiz , Douglas Melo Coutinho Henrique , Almeida Menezes Saulo , Bezerra Morais‐Braga Maria Flaviana , Morais de Oliveira Antonio Fernando 
Published: January 2024

AbstractThe fixed oil from the inner mesocarp of Caryocar coriaceum Wittm. is used in the Chapada do Araripe region of Brazil for the treatment of genitourinary candidiasis. This study aimed to evaluate the chemical composition, antifungal activity, reduction of fungal virulence, and the preliminary toxicity of the fixed oil from the inner mesocarp of C. coriaceum tested against three Candida yeasts. The oil was characterized by gas chromatography (GC‐MS and GC‐FID). Antifungal activity was assessed using the serial microdilution method. Additionally, the potential of the oil as an enhancer of fluconazole action was tested at sub‐inhibitory concentrations (MIC/8). The mechanism of action of C. coriaceum fixed oil was determined by evaluating the inhibition of morphological transition in Candida spp. The chemical composition of the fixed oil of C. coriaceum comprised both unsaturated and saturated fatty acids. Oleic (61 %) and palmitic (33 %) acids were the major constituents. Regarding its anti‐Candida activity, the oil inhibited the growth of C. albicans (IC50: 371 μg/mL) and C. tropicalis (IC50: 830 μg/mL). Furthermore, the oil reversed the antifungal resistance of C. albicans and C. tropicalis, restoring the susceptibility to fluconazole and reducing their IC50 from 12.33 μg/mL and 362 μg/mL to 0.22 μg/mL and 13.93 μg/mL, respectively. The fixed oil of C. coriaceum completely inhibited the morphological transition of C. albicans and C. tropicalis at a concentration of 512 μg/mL, but exhibited limited low antifungal potential against C. krusei. The observed antifungal activity may be attributed to the overproduction of reactive oxygen species. Additionally, the oil showed no toxic effect on the Drosophila melanogaster in vivo model. The fixed oil from the inner mesocarp of C. coriaceum emerge as a strong candidate for the development of new pharmaceutical formulations to treat infections caused by Candida spp.
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1
Authors: Carvalho Luís A. R. , Sousa Bárbara B. , Zaidman Daniel , Kiely‐Collins Hannah , Bernardes Gonçalo J. L. 
Published: January 2024

AbstractPROTAC linker design remains mostly an empirical task. We employed the PRosettaC computational software in the design of sulfonyl‐fluoride‐based PROTACs targeting acyl protein thioesterase 1 (APT1). The software efficiently generated ternary complex models from empirically‐designed PROTACs and suggested alkyl linkers to be the preferred type of linker to target APT1. Western blotting analysis revealed efficient degradation of APT1 and activity‐based protein profiling showed remarkable selectivity of an alkyl linker‐based PROTAC amongst serine hydrolases. Collectively, our data suggests that combining PRosettaC and chemoproteomics can effectively assist in triaging PROTACs for synthesis and providing early data on their potency and selectivity.
Exploring the influence of interfacial solvation on electrochemical CO2 reduction using plasmon‐enhanced vibrational sum frequency generation spectroscopy
Authors: Rebstock Jaclyn A. , Zhu Quansong , Baker L. Robert 
Published: January 2024

AbstractAlthough interfacial solvation plays an important role in determining carbon dioxide reduction (CO2R) kinetics, present understanding of the potential dependent properties of the electrochemical double layer under conditions relevant for CO2R remains limited. This article summarizes the development and recent applications of plasmon‐enhanced vibrational sum frequency generation (VSFG) spectroscopy to study the effects of cation hydration and interfacial solvation on CO2R using CO as a vibrational Stark reporter. Results show that electrolyte cations retain their entire solvation shell upon adsorption to inactive sites, while active sites retain only a single water layer between the gold surface and the cation. Measurements also show that the total interfacial electric field can be separated into two contributions: one from the electrochemical double layer (Stern field) and another from the polar solvation environment (Onsager field). Surprisingly, correlating VSFG spectra with reaction kinetics reveals that it is the solvation‐mediated Onsager field that governs the chemical reactivity at the electrode/electrolyte interface. Measuring the interfacial water spectra during electrocatalysis also provides evidence for the proton source during H2 evolution, which competes with CO2R in aqueous electrolyte. These findings highlight the importance of directly probing cation hydration and interfacial solvation, which mediates reaction kinetics at electrochemical interfaces.
Withdrawn: A Two‐Dimensional Laminated V2O5 Membrane for Metal Ions Separation
Authors: Zhang Yating , Zhang Zhenxin , Zhu Qianqian , Fang Wei 
Published: January 2024

AbstractWithdrawal: “A Two‐Dimensional Laminated V2O5 Membrane for Metal Ions Separation” by Yating Zhang, Zhenxin Zhang, Qianqian Zhu, Wei Fang, Chemie Ingenieur Technik 2021, 94: 152–156. The above article, published online on 2 December 2021 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/10.1002/cite.202100132) has been withdrawn by agreement between the authors, the journal's Editor in Chief, Sabine Wiederhold, and Wiley‐VCH GmbH.The withdrawal has been agreed following notification that the author Wei Fang has submitted this article without proper authorization and consent of third‐party collaborators. This issue has resulted in publication and disclosure of data protected by a confidentiality agreement.
Cumulative exposure to impaired fasting glucose and gastrointestinal cancer risk: A nationwide cohort study
Authors: Ahn Byeong Yun , Kim Bokyung , Park Sanghyun , Kim Sang Gyun , Han Kyungdo , Cho Soo‐Jeong 
Published: January 2024

AbstractBackgroundImpaired fasting glucose (IFG) is associated with the risk of various cancers, but the cumulative effect of IFG on gastrointestinal cancer risk remains unclear. This study evaluated the association between the cumulative exposure to IFG and gastrointestinal cancer risk.MethodsThe authors extracted data from the Korean National Health Insurance Service and health examination data sets. Among individuals ≥40 years old who were free of diabetes or cancer, 1,430,054 who underwent national health examinations over 4 consecutive years from 2009 to 2012 were selected and followed up until gastrointestinal cancer diagnosis, death, or December 31, 2019. The IFG exposure score (range, 0–4) was based on the number of IFG diagnoses over 4 years.ResultsThe median follow‐up duration was 6.4 years. Consistent normoglycemia for 4 years was found in 44.3% of the population, whereas 5.0% had persistent IFG and 50.7% had intermittent IFG. Compared to the group with an IFG exposure score of 0, groups with IFG exposure scores of 1, 2, 3, and 4 had a 5%, 8%, 9%, and 12% increased risk of gastrointestinal cancer, respectively (score 1: adjusted hazard ratio [aHR], 1.05; 95% confidence interval [CI], 1.01–1.08; score 2: aHR, 1.08; 95% CI, 1.04–1.12; score 3: aHR, 1.09; 95% CI, 1.05–1.14; score 4: aHR, 1.12; 95% CI, 1.06–1.19). Persistent IFG exposure was also associated with higher risks of individual cancer types (colorectum, stomach, pancreas, biliary tract, and esophagus).ConclusionsCumulative exposure to IFG is associated with an increased risk of developing gastrointestinal cancer, in a dose‐dependent manner.Plain Language Summary

Hyperglycemia, including both diabetes and prediabetes, has been associated with an increased risk of various cancers.
However, the cumulative effect of impaired fasting glucose on the risk of developing gastrointestinal cancer remains unclear.
A frequent diagnosis of impaired fasting glucose was dose‐dependently associated with a higher risk of developing overall gastrointestinal cancer.
Furthermore, risks of individual cancer types increased with persistent impaired fasting glucose.
Early detection of hyperglycemia and strict glycemic control can lower the risk of gastrointestinal cancer by reducing hyperglycemic burden.
Additionally, for some individuals, lifestyle changes such as managing metabolic syndrome or abstaining from alcohol may also be helpful.
Evaluation of Acarbose Bioequivalence in Healthy Chinese Populations Using Novel Pharmacodynamic End Points
Authors: Que Linling , Qian Zhenzhong , Xiang Xuemei , Ding Ying , Huang Kai , Bai Yichuan , Zhao Huanan , He Qing 
Published: January 2024

AbstractAcarbose is a widely used α‐glucosidase inhibitor for the management of postprandial hyperglycemia in patients with type 2 diabetes mellitus. Recent pilot studies on acarbose bioequivalence (BE) have successfully identified additional pharmacodynamic (PD) parameters as valid end points. Nevertheless, there was a scarcity of published pivotal studies using novel PD parameters. The purpose of the study is to investigate the acarbose BE using the new PD parameters. The study was conducted with an open, randomized, 2‐period crossover design. A total of 64 healthy Chinese volunteers received either the reference (R) or test (T) acarbose at a dose of 2×50 mg orally, followed by a 1‐week washout period. After sucrose treatment (baseline) and sucrose/acarbose co‐administration, serum glucose, and insulin concentrations were assessed. The rectifying approach yielded geometric mean ratios of 102.9% for maximum serum glucose concentration with deduction of glucose concentration at 0 hour and 105.3% for the area under the serum glucose concentration‐time curve profile 0‐2 hours after coadministration of sucrose and acarbose with deduction of baseline (AUC0‐2 h,r). The 90% confidence intervals of maximum serum glucose concentration with deduction of glucose concentration at 0 hour and the area under the serum glucose concentration‐time curve profile 0‐2 hours after coadministration of sucrose and acarbose with deduction of baseline all fell within the acceptance limits. The incidence of adverse events after the T or R drug was comparable, and healthy subjects were well tolerated. The findings of our investigation clearly show that the PD parameters of the rectifying method exhibit enhanced suitability and sensitivity when assessing acarbose BE in healthy participants. The T and R drugs were bioequivalent using the novel PD parameters, and both drugs demonstrated good safety and tolerability.
A novel member enhancement‐based clustering ensemble algorithm
Authors: He Yulin , Yang Jin , Cheng Yingchao , Du Xueqin , Huang Joshua Zhexue 
Published: January 2024

SummaryClustering ensemble is a popular approach for identifying data clusters that combines the clustering results from multiple base clustering algorithms to produce more accurate and robust data clusters. However, the performance of clustering ensemble algorithms is highly dependent on the quality of clustering members. To address this problem, this paper proposes a member enhancement‐based clustering ensemble (MECE) algorithm that selects the ensemble members by considering their distribution consistency. MECE has two main components, called heterocluster splitting and homocluster merging. The first component estimates two probability density functions (p.d.f.s) estimated on the sample points of an heterocluster and represents them using a Gaussian distribution and a Gaussian mixture model. If the random numbers generated by these two p.d.f.s have different probability distributions, the heterocluster is then split into smaller clusters. The second component merges the clusters that have high neighborhood densities into a homocluster, where the neighborhood density is measured using a novel evaluation criterion. In addition, a co‐association matrix is presented, which serves as a summary for the ensemble of diverse clusters. A series of experiments were conducted to evaluate the feasibility and effectiveness of the proposed ensemble member generation algorithm. Results show that the proposed MECE algorithm can select high quality ensemble members and as a result yield the better clusterings than six state‐of‐the‐art ensemble clustering algorithms, that is, cluster‐based similarity partitioning algorithm (CSPA), meta‐clustering algorithm (MCLA), hybrid bipartite graph formulation (HBGF), evidence accumulation clustering (EAC), locally weighted evidence accumulation (LWEA), and locally weighted graph partition (LWGP). Specifically, MECE algorithm has the nearly 23% higher average NMI, 27% higher average ARI, 15% higher average FMI, and 10% higher average purity than CSPA, MCLA, HBGF, EAC, LWEA, and LWGA algorithms. The experimental results demonstrate that MECE algorithm is a valid approach to deal with the clustering ensemble problems.
Feedback Supersaturation Control Crystallization Process of Itaconic Acid
Authors: Cui Hongyan , Song Liangcheng , Lv Sheng , Zhu Chongqiang , Yang Chunhui 
Published: January 2024

AbstractSeeding metastable zone of itaconic acid in water is determined using a laser dynamic detecting technique, based on which feedback supersaturation control is performed for the crystallization process. The crystallization is strictly confined within the metastable zone throughout the whole process to effectively inhibit the secondary nucleation and the strategy of seed loading is employed to avoid the burst of primary nucleation, resulting in the uniform particle size distribution. With the aid of solution information, continuous feedback control is conducted to keep the supersaturation at a high level accelerating the crystal growth, which significantly shortens the time consumption, and also the effect of seed amount is discussed in this work.
UAS for Precision Agriculture: State of the Art, Challenges, and Future Perspectives
Authors: Baath Gurjinder , Bawa Arun 
Published: January 2024

AbstractTo make precision agriculture work, we need to gather a lot of critical information about the field. Unmanned aircraft systems (UAS) introduced an era of on‐demand remote‐sensing data collection at fine spatial and temporal resolutions. With the help of UAS, detailed maps of the field can be generated, which can help farmers see how their crops are doing and where they might be facing challenges. These maps can also show if the farming methods are working well or if they need to be adjusted. In this article, we’ve provided an overview of the current state‐of‐the‐art UAS sensors and their applications, along with associated challenges and prospects of UAS mapping in agriculture. Earn 0.5 CEUs in Crop Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.
High‐Selectivity Recycling of Valuable Metals from Spent Lithium‐Ion Batteries Using Recyclable Deep Eutectic Solvents
Authors: Zhang Yaozhi , Wang Fang , Zhang Wanxiang , Ren Shuhang , Hou Yucui , Wu Weize 
Published: January 2024

AbstractThe recovery of valuable metals from spent lithium‐ion batteries using deep eutectic solvents (DESs) is an environmentally and economically beneficial process. In this study, a method has been developed for recovering LiNi0.33Co0.33Mn0.33O2. Our process operates under mild conditions and with a little oxalic acid as a reducing agent, dissolving lithium, cobalt, manganese, and nickel completely utilizing a DES that is composed of tetrabutylammonium chloride and of monochloroacetic acid. Lithium and nickel were selectively precipitated using oxalic acid. Cobalt and manganese were precipitated as oxalates by adding an oxalic acid aqueous solution. Finally, the DES can be regenerated by evaporating the water. Importantly, valuable metals can be recovered with a 100 % yield through the process of DES recycling. This environmentally friendly and recyclable process is suitable for the recycling of spent lithium‐ion batteries industry.