bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opioid characteristics and nonopioid interventions associated with successful opioid taper in patients with chronic noncancer pain
Authors: Jung Monica , Xia Ting , Ilomäki Jenni , Pearce Christopher , Nielsen Suzanne 
Published: December 2023

Abstract
Current research indicates that tapering opioids may improve pain and function in patients with chronic noncancer pain. However, gaps in the literature remain regarding the choice of opioid and nonopioid interventions to support a successful taper. This study used an Australian primary care data set to identify a cohort of patients on long-term opioid therapy commencing opioid taper between January 2016 and September 2019. Using logistic regression analysis, we compared key clinical factors associated with differing taper outcomes. Of a total of 3371 patients who commenced taper, 1068 (31.7%) completed taper within 12 months. In the 3 months after commencement of taper, compared with those who did not complete taper, patients who successfully completed opioid taper were less likely to be prescribed buprenorphine (odds ratio [OR] 0.691; 95% CI: 0.530-0.901), fentanyl (OR, 0.429; 95% CI: 0.295-0.622), and long-acting (LA) opioids, including methadone (OR, 0.349; 95% CI: 0.157-0.774), oxycodone–naloxone (OR, 0.521; 95% CI: 0.407-0.669), and LA tapentadol (OR, 0.645; 95% CI: 0.461-0.902), but more likely to be prescribed codeine (OR, 1.308; 95% CI: 1.036-1.652). Compared with those who did not complete taper, patients who successfully tapered were less likely to be prescribed any formulations of oxycodone (short-acting [SA]: OR, 0.533; 95% CI: 0.422-0.672, LA: OR, 0.356; 95% CI: 0.240-0.530) and tramadol (SA: OR, 0.370; 95% CI: 0.218-0.628, LA: OR, 0.317; 95% CI: 0.234-0.428). The type of opioid prescribed in the months after commencement of taper seems to influence the taper outcomes. These findings may inform prospective studies on opioid taper.
Plasma Interleukin-13 Levels Correlate With the Severity of Symptoms Induced by Functional Dyspepsia
Authors: Leites Marcos , Olano Carolina , Freire Teresa 
Published: December 2023

Objective:
Functional dyspepsia (FD) is a gastrointestinal functional disorder of the upper gastrointestinal tract that affects the quality of life of patients and poses a significant economic burden. It has been proposed that the local inflammatory immune response at the duodenum is associated with an increase in intestinal permeability, favoring the recruitment of Th2 cells and granulocyte degranulation. Moreover, systemic immune response could also be related to the symptoms of FD. The objective of this study was to evaluate the systemic immune response in Uruguayan patients with FD by analyzing the cytokine levels in plasma and the frequency of circulating T cells associated with duodenal recruitment.

Patients and Methods:
An analytic and cross-sectional study in 30 patients with FD and 15 healthy controls (HCs) was carried out. Patients were diagnosed with FD according to the Roma IV Committee definition. Cytokine levels were measured in plasma by a specific assay. Expression of α4β7 and CC chemokine receptor9 in circulating T cells was evaluated by flow cytometry.

Results:
Higher levels of interleukin (IL)-5, IL-13, and IL-8 and lower levels of IL-10 and IL-12p70 were detected in patients with FD than in HC. Furthermore, a positive linear correlation between IL-13 and the severity of FD symptoms was found. CD4+ T cells from patients with FD expressed higher levels of α4β7 and CC chemokine receptor9 than those from HC.

Conclusions:
An increase of Th2-like cytokines and a positive correlation between the levels of plasma IL-13 and the severity of symptoms in patients with FD from Uruguay were detected.
Post-traumatic recurrent ulnar nerve dislocation at the elbow: a rare case report
Authors: Nguyen Huu Manh , Tran Quyet , Vu Duc Viet , Trung Dung Tran 
Published: December 2023

Introduction and importance:
Several authors have also made reference to a less prevalent condition known in elbow as ulnar nerve subluxation. However, this particular condition tends to manifest primarily in young individuals who engage in professional sports or activities involving extensive use of the forearm. A more severe form of ulnar nerve subluxation, which is ulnar nerve dislocation, gives rise to a characteristic dislocation and relocation of the nerve at the elbow during flexion and extension of the forearm. Due to the rarity of this condition in clinical settings and its predominant occurrence as subluxation in younger patients, there are instances where traumatic ulnar nerve dislocation can be overlooked and misdiagnosed with two commonly encountered pathological conditions as ulnar nerve entrapment or medial epicondylitis.

Case presentation:
The authors present a 51-year-old male with chronic pain when moving his right forearm following a fall that caused a direct force injury to his elbow. The patient was misdiagnosed and treated as medial epicondylitis and early-stage ulnar nerve entrapment. However, the symptoms did not improve for a long time. The authors performed the ulnar nerve anterior transposition surgery using the subcutaneous transposition technique and the result is very good without any pain.

Clinical discussion:
The ulnar nerve can naturally be subluxed or dislocated if Osborne’s ligament is loose or when there are anatomical variations in the medial epicondyle. In some case, this ligament can be ruptured by trauma. The symptoms of ulnar instability are caused by friction neuritis. Dynamic ultrasound of the ulnar nerve in two positions show clearly this condition.

Conclusion:
Post-traumatic ulnar nerve dislocation is a rare condition, and the recurrent characteristic of it leads to neuritis or neuropathy. The condition can be overlooked or misdiagnosed as medial epicondylitis or early-stage ulnar nerve entrapment. The nerve transposition surgery will give good result.
Embracing My Stoma: Psychosocial Adjustment of Indonesian Colorectal Cancer Survivors Living With a Stoma
Authors: Afiyanti Yati , Milanti Ariesta , Wahidi Kemala Rita , Fitch Margaret 
Published: December 2023

Background
After surgical treatment of colorectal cancer (CRC), most survivors need to have an ostomy, which can lead to restrictions in their psychological and social functioning. How Indonesian CRC survivors adjust to living well with the stoma remains an understudied area.

Objective
This study aimed to explore the lived experiences of Indonesian CRC survivors living with a stoma regarding their psychosocial adjustment.

Methods
This study adopted Heidegger’s interpretive phenomenology approach. Using semistructured in-depth interviews, data were collected until saturation from 11 CRC survivors. Data were analyzed using thematic analysis, with a Heideggerian stance.

Results
Three themes with corresponding subthemes were identified: (1) achieving self-reconciliation (subthemes: stoma as a savior, embracing the stoma’s existence, being confident as an ostomate), (2) getting tremendous social support (subthemes: getting support from partner, family and community, and peer ostomates), and (3) making practical adjustments in daily life (subthemes: adjustment in clothing, food and drink, physical activities and exercise, religious activities, and traveling). These 3 themes describe the essence of the “lived psychosocial experiences of the CRC survivors with stoma.”

Conclusions
In contrast to previous study findings conducted primarily in Western countries, most of the Indonesian CRC survivors living with a stoma described positive psychosocial adjustment regarding their ostomy. In this work, social support and cultural-religious aspects made a significant contribution to this adjustment.

Implications for Practice
Healthcare professionals, especially nurses, can use this knowledge in providing psychosocial support for CRC survivors with ostomy to facilitate a smooth adaptation and adjustment journey.
Affirming Care for Transgender and Gender-Diverse Youth
Authors: Roosevelt Lee K. , Kattari Leonardo , Yingling Charles 
Published: December 2023

Abstract
Nurses play a critical role in providing gender-affirming care for transgender and gender-diverse youth. With heightened debate about the clinical care for transgender and gender-diverse youth in the national and global spotlight, now more than ever before nurses must equip themselves with the knowledge and the evidence spanning more than 4 decades that support the clinical use of gender-affirming care for youth and young adults. By exploring gender development and gender-affirming care approaches through the lifespan perspective, this review provides an up-to-date discussion about best practices and clinical implications for providing equitable care for transgender and gender-diverse youth from birth to childhood and through adolescence developmental phases. A transgender and gender-diverse youth's future willingness to access health care is dependent on how positive their interactions are with their care team at this sensitive moment in their life. Nurses must not let political rhetoric impede their practice and ethical guidelines to provide competent, skilled, and unbiased care. Knowledgeable, informed, and empowered nurses can provide life-saving care to transgender and gender-diverse youth and their families.
Mpox in people living with HIV
Authors: Maan Irfaan , Kohli Manik , Gilson Richard 
Published: December 2023

Purpose of review
The 2022 global outbreak of mpox disproportionally affected people with HIV (PWH). We review the data on the presentation, treatment, and prevention of mpox in PWH.

Recent findings
Most PWH with mpox had a mild and self-limiting illness, no different to people without HIV. A higher rate of rectal symptoms has been reported among PWH and those with advanced HIV disease were at higher risk of severe disease, hospitalization, and death. Treatment with antivirals was widely used in hospitalized patients without any randomized control trial data to support its use and without any data specifically in PWH. Use of smallpox vaccines to prevent mpox is safe in PWH regardless of CD4+ cell count. There is limited data on efficacy in those with lower CD4+ cell count and on long-term protective efficacy.

Summary
PWH should be offered vaccination against mpox in line with national guidelines. PWH should be individually risk-assessed for severe mpox, based on their CD4+ cell count and co-morbidities and ideally recruited into treatment trials to build an evidence base on efficacy. HIV and other sexually transmitted infection testing should be offered to all people diagnosed with mpox.
Krukenberg Tumors in Young Women: Computed Tomography and Magnetic Resonance Imaging Diagnosis
Authors: Ghahremani Gary G. 
Published: December 2023

Introduction
The purpose of this report was to present the computed tomography (CT) and magnetic resonance imaging (MRI) features of Krukenberg tumors and to review the pertinent clinical data about the rising incidence of this malignancy among young women.

Material and Methods
This series included 8 women who ranged in age from 24 to 44 years (mean, 36.3 years). They were diagnosed to have Krukenberg tumors during a 5-year period (2011–2016). All patients were evaluated by abdominal CT and pelvic or transvaginal sonography. Five of them also had MRI of the abdomen, and 3 had positron emission tomography scans.

Results
The primary cancer was located in the stomach of 7 patients and in the colon in 1. The initial presentation was due to large pelvic mass and abdominal distention by ascites in 3 patients, gastrointestinal symptoms in 4, and small bowel obstruction by carcinoma of the ascending colon in 1 woman. Ovarian metastases were demonstrated on the initial imaging examination of 5 patients and developed as metachronous lesion during follow-up in 3 cases. Six women died 3 to 23 months (mean, 11 months) after the diagnosis. One has survived for 6 years after extensive surgery, and 1 was lost to follow-up.

Conclusions
Krukenberg tumors are being diagnosed with an increasing frequency because of well-documented rising incidence of gastric and colorectal carcinomas among young women. Therefore, those presenting with gastrointestinal cancer should have careful imaging of their ovaries for possible metastases, and conversely, the clinical or sonographic detection of bilateral ovarian masses would require evaluation by CT or MRI of the abdomen in search for a potential primary gastrointestinal cancer. This report highlights the CT and MRI features of this neoplastic process and reviews the current concepts about its development and management.
Quantitative comparison on the similarities and differences of Mongolian medicines in the treatment of liver diseases between China and Mongolia based on data mining
Authors: Huang Congying , Zhou Baochang , Chen Aruhan , La Budanbaila , Ye Yu , Liu Yibo , Zhang Xinyu , Sun Yanhong , Bo Agula , Li Minhui 
Published: December 2023

Abstract

Objective
The R language was used to quantitatively compare the medication patterns of Mongolian medicines used for the treatment of liver diseases between China and Mongolia, with a view to provide a reference for the research and clinical application of Mongolian medicines in the treatment of liver diseases.

Methods
The Mongolian medicinal prescriptions used for treating liver disease in Mongolia were collected from the Mongolian Pharmacy and Mongolian Treatment Guide for Common diseases in Mongolian Medicine, and those used in China were collected from the Inner Mongolia Standard for Mongolian Proprietary Medicine and Annotation of Mongolian Medicine Preparation Specifications. After the database was established, the frequency, properties, and tastes of the Mongolian medicines were analyzed, and R studio was used for the association rules analysis and cluster analysis.

Results
A total of 27 prescriptions used in Inner Mongolia, China, were collected involving 105 Mongolian medicines, with a total frequency of 284. Among them, there were 18 high-frequency medicines (frequency ≥5), which had a frequency of 147, accounting for 51.76% of the total frequency. The medicine with the highest frequency (14, 4.93%) was Carthamus tinctorius L.. The analysis of the medicine data in China revealed 15 association rules.
A total of 21 prescriptions used in Mongolia were collected, involving 92 Mongolian medicines, with a total frequency of 254. Among them, there were 17 high-frequency (frequency ≥5) medicines, with a total frequency of 124 (48.82%). The medicine with the highest frequency (13, 5.12%) was Carthamus tinctorius L.. The analysis of the medicine data in Mongolia revealed 79 association rules.
In both regions, the high-frequency medicines used for treating liver disease commonly had cool or warm property with bitter or sweet taste.

Conclusions

Carthamus tinctorius L., Terminalia chebula Retz., and other Mongolian medicines are commonly used to treat liver diseases in Inner Mongolia and Mongolia. The Mongolian medicines with cool or warm property and bitter, sweet, or astringent taste are commonly used to protect the liver.
Safety Assessment of Five Candidate Probiotic Lactibacilli using Comparative Genome Analysis
Authors: Altavas Patrick Josemaria del Rosario , Amoranto Mia Beatriz , Kim Sang Hoon , Kang Dae-Kyung , Balolong Marilen , Dalmacio Leslie Michelle 
Published: December 2023

Microorganisms belonging to the Lactobacillus genus complex (LGC) are often used for oral consumption and are generally considered safe but can exhibit pathogenesis in rare and specific cases. Therefore, screening and understanding genetic factors that may contribute to pathogenicity can yield valuable insights regarding probiotic safety. Limosilactobacillus mucosae LM1, Lactiplantibacillus plantarum SK151, Lactiplantibacillus plantarum BS25, Limosilactobacillus fermentum SK152, and Lactobacillus johnsonii PF01 are current probiotics of interest; however, their safety profiles have not been explored. The genome sequences of LM1, SK151, SK152, and PF01 were downloaded from the NCBI GenBank, while that of L. plantarum BS25 was newly sequenced. These genomes were then annotated using the Rapid Annotation using Subsystem Technology (RAST) tk pipeline. Subsequently, a command line BLAST was performed against the Virulence Factor Database (VFDB) and the Comprehensive Antibiotic Resistance Database (CARD) to identify potential virulence factors and antibiotic resistance (AR) genes. Furthermore, ResFinder was used to detect acquired AR genes. The query against the VFDB identified genes that have a role in bacterial survivability, platelet aggregation, surface adhesion, biofilm formation and immunoregulation; and no acquired AR genes were detected using CARD and ResFinder. The study shows that the query strains exhibit genes identical to those present in pathogenic bacteria with the genes matched primarily having roles related to survival and surface adherence.
Tianweitania aestuarii sp. nov., isolated from a coastal dune, reclassification of Corticibacterium populi as Tianweitania populi comb. nov., and emended description of the genus Tianweitania
Authors: Song Ji Hyeon , Park Sooyeon , Lee Jung-Sook , Kim Wonyong , Yoon Jung-Hoon 
Published: December 2023

A Gram-stain-negative, aerobic, non-flagellated and coccoid or ovoid bacterial strain, BSSL-BM11T, was isolated from sand of coastal dunes along the Yellow Sea of the Korean peninsula. Strain BSSL-BM11T grew optimally at 30 °C, at pH 7.0–8.0 and in the presence of 2.0–3.0 % (w/v) NaCl. Phylogenetic trees based on 16S rRNA gene sequences, the up-to-date bacterial core gene set and average amino acid identity (AAI) showed that strain BSSL-BM11T forms a cluster with the type strains of

Tianweitania sediminis

and

Corticibacterium populi

. Strain BSSL-BM11T showed 16S rRNA gene sequence similarities of 98.3 and 98.0 % to the type strains of

T. sediminis

and

C. populi

, respectively, and less than 96.4 % to the type strains of the other recognized species. The average nucleotide identity (ANI) and digital DNA–DNA hybridization (dDDH) values between strain BSSL-BM11T and the type strains of

T. sediminis

and

C. populi

were 77.0–84.8 % and 20.0–28.1 %, respectively. The 16S rRNA gene similarity, AAI, ANI and dDDH values between

T. sediminis

Z8T and

C. populi

KCTC 42249T were 98.0, 77.4, 76.7 and 20.1 %, respectively. The DNA G+C content of strain BSSL-BM11T from genomic sequence data was 61.3 mol%. Strain BSSL-BM11T contained Q-10 as the predominant ubiquinone and C18 : 1
ω7c, C16 : 0 and cyclo C19 : 0
ω8c as the major fatty acids. The major polar lipids of strain BSSL-BM11T were phosphatidylcholine, phosphatidylglycerol and phosphatidylethanolamine. Based on the polyphasic data, it is proposed that C, populi be reclassified as a member of the genus

Tianweitania

. Phenotypic and phylogenetic analyses revealed that strain BSSL-BM11T is separated from

T. sediminis

and

C. populi

. On the basis of the data presented here, strain BSSL-BM11T (=KACC 21634T=NBRC 114503T) is considered to represent a novel species of the genus

Tianweitania

, for which the name Tianweitania aestuarii sp. nov. is proposed.
Characteristics and outcomes of patients treated with sotrovimab to prevent progression to severe COVID-19 in Belgium
Authors: Drysdale Myriam , Hautekiet Thor , Singh Moushmi , Hautekiet Joris , Ludikhuyze Linda , Patel Vishal , Gibbons Daniel C , Roeck Dorothée De , Colpaert Kirsten , Lloyd Emily J , Braeckel Eva Van 
Published: December 2023

AbstractBackgroundSotrovimab, a dual-action, engineered human monoclonal antibody, has been demonstrated to significantly reduce the risk of hospitalization and death in high-risk patients with COVID-19. Here, we describe the real-world use of, and outcomes from, sotrovimab treatment in Belgium during the Delta and Omicron waves among patients with COVID-19 at high risk of developing severe disease.MethodsThis was a multicentric, single-arm observational cohort study of non-hospitalized patients receiving outpatient sotrovimab treatment between 1 November 2021 and 2 August 2022. We performed a retrospective analysis of hospital, pharmacy and administrative data from nine hospitals in Belgium. The primary outcomes were all-cause and COVID-19-related hospitalizations and all-cause deaths during the 29-day acute follow-up period from first administration of sotrovimab.ResultsA total of 634 patients were included in the analysis (63.4% aged <65 years; 50.3% male). A high proportion (67.7%;n= 429/634) of patients were immunocompromised, with 36.9% (n= 234/634) actively treated for malignancy. During the 29-day acute period, 12.5% (n= 79/634) of sotrovimab-treated patients were hospitalized due to any cause (median duration 4 days; median time to hospitalization 14 days) and 1.1% (n= 7/634) died due to any cause. In total, 0.8% (n= 5/634) of patients were admitted to an intensive care unit (ICU). COVID-19-related hospitalization was experienced by 2.5% (n= 16/634) of patients (median duration 10 days; median time to hospitalization 10.5 days), with 0.5% (n= 3/634) of patients admitted to an ICU. COVID-19-related hospitalization was experienced by 6.3% (n= 3/48) of patients during Delta predominance (04/11/2021–23/12/2021), 6.3% (n= 1/16) of patients during Delta/BA.1 codominance (24/12/2021–01/01/2022), 1.4% (n= 3/218) of patients during BA.1 predominance (02/01/2022–09/02/2022), 2.1% (n= 2/97) of patients during BA.1/BA.2 codominance (10/02/2022–07/03/2022) and 2.7% (n= 7/255) of patients during BA.2/BA.5 codominance (08/03/2022–02/08/2022).ConclusionsThis observational study demonstrated consistently low rates of COVID-19-related hospitalizations and all-cause deaths in sotrovimab-treated patients during the Omicron subvariant periods in Belgium, despite over two-thirds of the study population being immunocompromised. Comparative effectiveness studies are warranted to confirm sotrovimab effectiveness in highly immunocompromised patients with COVID-19.