bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of pyoderma gangrenosum in pregnancy with certolizumab pegol
Authors: Wanberg Lindsey J. , Fletcher Kathleen M. , Goldfarb Noah , Alavi Afsaneh 
Published: December 2023

AbstractWe report a case of a 41‐year‐old woman who developed pregnancy‐associated pyoderma gangrenosum (PG) at 4 weeks gestation. She was initially treated with prednisone, however, due to lack of improvement and risk of systemic corticosteroids in pregnancy, underwent a prednisone taper and was initiated on certolizumab pegol (CZP). The patient experienced complete wound re‐epithelialization 1 month after CZP initiation. She had no pregnancy complications except for prednisone‐associated gestational diabetes and gave birth to a healthy baby. CZP is a tumour necrosis factor‐inhibitor with negligible placental transfer and no known adverse effects in pregnancy. Its efficacy and safety for autoinflammatory dermatoses in pregnancy are very promising. This is the first case to report CZP treatment for PG in a pregnant patient.
Biobased Vitrimeric Epoxy Networks
Authors: Sangermano Marco , Bergoglio Matteo , Schögl Sandra 
Published: December 2023

AbstractThe scientific strategies reported in the literature for developing biobased epoxy vitrimers are summarized. Biomass resources such as lignin, cellulose, or different vegetable oils can be exploited as biobased building blocks for epoxy thermosets as an alternative to the bisphenol‐A‐based ones. Biorenewable resources have been synthesized introducing dynamic covalent bonds in the cross‐linked networks. This combination allows to achieve cross‐linked biobased epoxy networks with thermoset‐like properties at a temperature of use, but showing (re)processability, recyclability, and self‐healing properties above a well‐defined temperature named topology freezing transition temperature (Tv).
Tunable and Biodegradable Poly(Ester Amide)s for Disposable Facemasks
Authors: Seoane Esteban Alvarez , Cattaneo Alessandro , Neuenschwander Fabien , Blanchard Lucien , Nogueira Matos Tatiana , Jeandupeux Laure , Fiorucci Gianni , Tizgadam Maryam , Tran Kelly , Sciboz Pierre‐Louis , Albergati Luce , Charmet Jérôme , Marti Roger , Hengsberger Stefan 
Published: December 2023

AbstractThe widespread use of disposable facemasks during the COVID‐19 pandemic has led to environmental concern due to microplastic pollution. Biodegradable disposable facemasks are a first step to reducing the environmental impact of pandemics. Here, high‐performance facemask components based on novel poly(ester amide)s (PEA) grades synthesized from biosourced materials and processed into nonwoven facemask components are presented. PEA‐based polymers present an excellent compromise between mechanical performance and biodegradability. Importantly, the properties of the PEA can easily be tuned by changing the ratio of ester and amide, or by varying diol and diacid parts. Seven polymers are synthesized which are optimized for biodegradability and processability. Among them, two grades combines 1) electrospinning process compatibility with 2) full degradation within 35 days, using a normalized biodegradation test. The ultra‐thin filters thus developed are evaluated for performance on a custom‐made characterization bench. The filters achieve microparticle capture efficiency and air permeability comparable to commercial filters. Another PEA grade is optimized to reach optimal viscothermal properties that made it compatible with solvent‐free melt‐spinning process as demonstrated with continuous fiber production. Overall, this environmentally friendly solution paves the way for the fabrication of high‐performance fibers with excellent biodegradability for the next‐generation facemasks.
Nutritional value of torula yeast as an alternative protein feedstuff for hybrid Striped Bass (White Bass × Striped Bass)
Authors: Chen Kequan , Yamamoto Fernando Y. , Cruz Clement R. , Gatlin Delbert M. 
Published: December 2023

Abstract

Objective
Two separate trials were conducted to evaluate the digestibility of a novel alternative ingredient, enhanced torula yeast (TY) Cyberlindnera jadinii, in diets for hybrid Striped Bass (HSB; White Bass Morone chrysops × Striped Bass M. saxatilis) and to evaluate graded inclusion levels of this product when replacing soybean products.

Methods
In trial 1, the digestibility of TY was determined by testing a reference diet and a TY diet (reference and TY ingredient at an 80:20 ratio). A total of 90 fish were fed the experimental digestibility diets for 21 days, and fecal samples were collected using the stripping technique. In trial 2, a comparative feeding trial evaluated the replacement of soybean meal by TY on a crude protein basis at 50, 100, 200, and 300 g of TY/kg of experimental diet. A total of 150 HSB (18.6 ± 0.21 g/fish [mean + SE]) were distributed among fifteen 110-L glass aquaria. Each diet was fed to triplicate groups of fish for 9 weeks.

Result
In trial 1, apparent digestibility coefficients for protein, lipid, organic matter, and energy of TY were 0.97, 0.98, 0.75, and 0.75, respectively. The availability of essential amino acids also was generally high, ranging from 0.74 to 0.99. For trial 2, a second-order polynomial regression indicated that the optimal inclusion levels of TY in diets were 102, 112, and 109 g/kg for weight gain, feed efficiency, and protein conversion efficiency, respectively. However, the muscle yield linearly decreased with the graded inclusion levels of TY. Linear increases in intraperitoneal fat, hepatosomatic index, and whole-body lipid were observed as the inclusion of TY increased in the diet.

Conclusion
In conclusion, nutrients from TY were well utilized by HSB, and it can replace soybean products without affecting growth performance, with the optimal TY inclusion level being 102–112 g/kg of diet.
The effects of estradiol-17β on the sex reversal, survival, and growth of Red Shiner and its use in the development of YY individuals
Authors: Teal Chad N. , Schill Daniel J. , Bauder Javan M. , Fogelson Susan B. , Fitzsimmons Kevin , Stewart William T. , Culver Melanie , Bonar Scott A. 
Published: December 2023

Abstract

Objective
The Red Shiner Cyprinella lutrensis is one of the most prolific and ecologically destructive invasive fish species in the southwestern United States. The production and release of YY individuals as Trojan sex chromosome carriers can theoretically eradicate invasive fish populations by eventually eliminating phenotypic females.

Methods
The YY individuals are typically produced through hormonally induced sex reversals and selective breeding of subsequently feminized males. We tested three dosages of estradiol-17β (E2)-treated diets (50, 100, and 150 mg of E2 per kg of diet) administered to sexually immature Red Shiner for various durations to determine their effectiveness at feminizing Red Shiner cohorts. Survival, growth, and gonadal development were assessed for each treatment.

Result
All E2 treatments had minimal, if any, detrimental effects on the growth and gonadal development of Red Shiner. The 50-mg dosage lasting from 2 to 120 days posthatch achieved a 100% feminization rate while using the lowest amount of E2; therefore, this dosage and treatment interval are recommended when attempting Red Shiner feminization under these rearing conditions. Feminization of males allowed for the spawning of neofemales (FXY) with wild-type males (MXY), which resulted in the first putative YY Red Shiner. The YY verification crosses (n = 20) resulted in predominately male offspring (189 males/191 offspring) except for (1) an intersex individual from an MYY × FXX cross with two previtellogenic oocytes in its testis and (2) a single female that may have resulted from an inbred cross between an XY male and a YY female or from an unknown autosomal or environmental effect on sexual phenotype.

Conclusion
More progeny tests with inbred and outbred crosses should be conducted to determine the prevalence of female offspring from YY individuals and how this may impact an eradication strategy featuring releases of YY Red Shiner.
Real world study on elexacaftor‐tezacaftor‐ivacaftor impact on cholesterol levels in adults with cystic fibrosis
Authors: Lonabaugh Kevin , Li Galvin , List Rhonda , Huang Reyna , James Amber , Barros Andrew , Somerville Lindsay , Albon Dana 
Published: December 2023

AbstractIntroductionThe introduction of the highly effective modulator therapy elexacaftor‐tezacaftor‐ivacaftor (ETI) has revolutionized the care of persons with cystic fibrosis (PwCF) with major improvements seen in lung function and body mass index. The effects of ETI therapy in real‐world cohorts on other parameters such as cholesterol levels are largely unknown.MethodsA single‐center, retrospective chart review study was conducted to assess the change in lipid panels before and after ETI initiation. The study investigated total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and triglyceride levels using both a univariate and multivariate mixed‐effects model to evaluate the change after initiation of ETI in a cohort of PwCF.ResultsThere were 128 adult PwCF included in the analysis. Statistically significant changes were seen in both univariate and multivariate analyses for TC, LDL‐C, and HDL‐C. On multivariate analysis, TC increased by an average of 15.0 mg/dL after ETI initiation (p < 0.0001), LDL‐C increased by an average of 9.3 mg/dL (p < 0.001), and HDL‐C increased by an average of 3.8 mg/dL (p < 0.001) after ETI initiation.ConclusionIn this real‐world cohort of PwCF, cholesterol parameters increased after initiation with ETI therapy. Further consideration may need to be given for PwCF in regards to screening for cardiometabolic risk factors as PwCF age as well as the potential need for cholesterol‐lowering therapies.
Integration of proteomics in the molecular tumor board
Authors: Thiery Johanna , Fahrner Matthias 
Published: December 2023

AbstractCancer remains one of the most complex and challenging diseases in mankind. To address the need for a personalized treatment approach for particularly complex tumor cases, molecular tumor boards (MTBs) have been initiated. MTBs are interdisciplinary teams that perform in‐depth molecular diagnostics to cooperatively and interdisciplinarily advise on the best therapeutic strategy. Current molecular diagnostics are routinely performed on the transcriptomic and genomic levels, aiming to identify tumor‐driving mutations. However, these approaches can only partially capture the actual phenotype and the molecular key players of tumor growth and progression. Thus, direct investigation of the expressed proteins and activated signaling pathways provide valuable complementary information on the tumor‐driving molecular characteristics of the tissue. Technological advancements in mass spectrometry‐based proteomics enable the robust, rapid, and sensitive detection of thousands of proteins in minimal sample amounts, paving the way for clinical proteomics and the probing of oncogenic signaling activity. Therefore, proteomics is currently being integrated into molecular diagnostics within MTBs and holds promising potential in aiding tumor classification and identifying personalized treatment strategies. This review introduces MTBs and describes current clinical proteomics, its potential in precision oncology, and highlights the benefits of multi‐omic data integration.
Microphysical mechanisms of wintertime postfrontal precipitation enhancement over the Australian Snowy Mountains
Authors: Gevorgyan Artur , Siems Steven , Huang Yi , Ackermann Luis , Manton Michael 
Published: December 2023

AbstractA heavy orographic precipitation event associated with the postfrontal sector of a midlatitude cyclone over the Australian Snowy Mountains (ASM) was analyzed using field observations and numerical simulations. This event, observed during a 2018 intensive field campaign, was of particular interest as three distinct precipitation episodes were identified within a prolonged postfrontal period. Deep mixed‐phase clouds (MPCs) characterized by cold cloud‐top temperatures (colder than −30°C) and the presence of updrafts extending 3.5–4.5 km above the boundary‐layer height, produced the three enhanced precipitation events over the windward slopes of the ASM. The presence of conditional instabilities and deep updrafts were also found in the sounding and Doppler velocity observations respectively, while the cloud radar observations show the deep MPCs with cloud tops reaching to 6–7 km a.s.l. Orographic convection invigoration was found to be the main mechanism producing the precipitation enhancement over the windward slopes and higher terrain. Using the Weather Research/Forecasting model, we analyzed the rates of microphysical processes to explicitly account for the enhancement of precipitation formation processes in these MPCs. This analysis showed that the precipitation formation processes were further enhanced through depositional and riming growth of ice‐phase hydrometeors during the three precipitation events. Deposition is simulated at higher levels (above the −15°C level) and most likely enabled by deep convective updrafts through the midtroposphere, whereas riming is stronger at lower levels (below −10°C level) due to the persistent production of feeder supercooled liquid water clouds sustained by the orographic lifting.
The tropical influence on sub‐seasonal predictability of wintertime stratosphere and stratosphere–troposphere coupling
Authors: Karpechko Alexey Yu. , Vitart Frederic , Statnaia Irina , Alonso Balmaseda Magdalena , Charlton‐Perez Andrew James , Polichtchouk Inna 
Published: December 2023

AbstractA unique set of relaxation experiments with a forecast model initialized during December–January 1999–2019 is used to explore tropical influence on the Northern Hemisphere polar stratosphere and stratosphere–troposphere coupling, to quantify predictability benefits due to the perfect knowledge of the tropical variability. On average, predictability of the polar stratosphere, as represented by the 50 hPa geopotential height anomalies north of 50°N (Z50), increases from 17 days in freely running (control) forecasts to 21 days in the tropical relaxation experiments. At sub‐seasonal time‐scales, a statistically significant improvement in weekly mean skill scores can be demonstrated in 14%–20% of individual forecast ensembles, mostly in cases when the skill of the corresponding control forecast is worse than average. In these forecasts, root‐mean‐square errors and forecast spread of Z50 during forecast weeks 3–5 are decreased by 10%–15%. Stratospheric improvements are detected during periods of both vortex strengthening and vortex weakening, including most major Sudden Stratospheric Warmings that occurred during the study period, via modulation of the upward wave activity fluxes. An active Madden–Julian Oscillation (MJO) is found in most of these events with MJO phase 5–7 preceding vortex weakening and MJO phase 3–4 preceding vortex strengthening. Forecasts with improved stratospheric circulation also have improved tropospheric circulation during and after the periods when improvements are detected in the stratosphere. We attribute these improvements to both stratosphere–troposphere coupling and tropospheric tropical teleconnections.
Effects of Counter‐Rotating Couplings on the Dynamics of a Λ System: Long‐Lived Coherence Oscillations
Authors: Xiang Jundong , Lü Zhiguo , Yan Yiying 
Published: December 2023

AbstractThe time evolution of the ground‐state population and coherence of a Λ‐type three‐level emitter strongly coupled to a radiation reservoir is studied by using a transformed rotating‐wave approximation (TRWA) and time‐dependent variational approach with the multiple Davydov ansatz. The study aims at illustrating the role of counter‐rotating couplings in the long‐time evolution of the Λ system. The TRWA and variational approach are found to be consistent with each other and predict that there exist long‐lived oscillatory behaviors of ground‐state populations and coherence, which are robust in the presence of strong dissipation and arise from the counter‐rotating‐coupling‐induced virtual photon processes. The oscillation amplitude and frequency depend on the system‐reservoir coupling strength and the frequency difference between the two ground states, which can be qualitatively and quantitatively captured by the TRWA analytical results. Present results offer insights into the impact of the counter‐rotating couplings on the long‐time evolution of the strongly dissipative multilevel system as well as the protocol of generation of coherent oscillations by relaxation in a strong‐coupling regime.
Broadband Spectroscopy and Interferometry with Undetected Photons at Strong Parametric Amplification
Authors: Hashimoto Kazuki , Horoshko Dmitri B. , Chekhova Maria V. 
Published: December 2023

AbstractNonlinear interferometry with entangled photons allows for characterizing a sample without detecting the photons interacting with it. This method enables highly sensitive optical sensing in the wavelength regions where efficient detectors are still under development. Recently, nonlinear interferometry has been applied to interferometric measurement techniques with broadband light sources, such as Fourier‐transform infrared spectroscopy and infrared optical coherence tomography. However, they have been demonstrated with photon pairs produced through spontaneous parametric down‐conversion (SPDC) at a low parametric gain, where the average number of photons per mode is much smaller than one. The regime of high‐gain SPDC offers several important advantages, such as the amplification of light after its interaction with the sample and a large number of photons per mode at the interferometer output. This work presents broadband spectroscopy and high‐resolution optical coherence tomography with undetected photons generated via high‐gain SPDC in an aperiodically poled lithium niobate crystal. To prove the principle, reflective Fourier‐transform near‐infrared spectroscopy with a spectral bandwidth of 17 THz and optical coherence tomography with an axial resolution of 11 µm are demonstrated.
Green Synergy Conversion of Waste Graphite in Spent Lithium‐Ion Batteries to GO and High‐Performance EG Anode Material
Authors: Yang Shenglong , Yang Guangchang , Lan Maoting , Zou Jie , Zhang Xiaohui , Lai Feiyan , Xiang Dinghan , Wang Hongqiang , Liu Kui , Li Qingyu 
Published: December 2023

AbstractThe increasing demand for graphite and the higher lithium content than environment abundance make the recycling of anode in spent lithium‐ion batteries (LIBs) also become an inevitable trend. This work proposes a simple pathway to convert the retired graphite to high‐performance expanded graphite (EG) under mild conditions. After the oxidation and intercalation by FeCl3for the retired graphite, H2O2molecules are more likely to penetrate into the extended layers. And the gas phase diffusion caused by the produced O2from the redox reaction between FeCl3and H2O2further promotes lattice expansion of interlayers (0.535 nm), which is beneficial to the stripping of graphene oxide (GO) with fewer layers. The EG exhibits excellent electrochemical performances in both LIBs and sodium‐ion batteries (SIBs). It delivers 331.5 mAh g−1at 3C (1C = 372 mA g−1) in LIBs, while it achieves 176.8 mAh g−1at 3C (1C = 120 mA g−1) in SIBs. Then the capacity retains 753.6 (LIBs) and 201.6 (SIBs) mAh g−1after a long‐term cycling of 500 times at 1C, respectively. The full cells with the EG electrodes after prelithium/presodiation also show excellent cycle stability. Thus, this work offers another referable strategy for the recycling of waste graphite in spent LIBs.
Defect Engineering of Metal Halide Perovskite Nanocrystals via Spontaneous Diffusion of Ag Nanocrystals
Authors: Jeon Sanghyun , Ahn Junhyuk , Jung Myung‐Chul , Woo Ho Kun , Bang Junsung , Jung Byung Ku , Oh Seongkeun , Lee Sang Yeop , Lee Kyu Joon , Paik Taejong , Ha Don‐Hyung , Ahn Jae‐Pyoung , Jeong Sohee , Kim Dong Hoe , Noh Jun Hong , Jang Ho Seong , Han Myung Joon , Oh Soong Ju 
Published: December 2023

AbstractPerovskite nanocrystals (NCs) have emerged as a promising building block for the fabrication of optic‐/optoelectronic‐/electronic devices owing to their superior characteristics, such as high absorption coefficient, rapid ion mobilities, and tunable energy levels. However, their low structural stability and poor surface passivation have restricted their application to next‐generation devices. Herein, a drug delivery system (DDS)‐inspired post‐treatment strategy is reported for improving their structural stability by doping of Ag into CsPbBr3 (CPB) perovskite NCs; delivery to damaged sites can promote their structural recovery slowly and uniformly, averting the permanent loss of their intrinsic characteristics. Ag NCs are designed through surface‐chemistry tuning and structural engineering to enable their circulation in CPB NC dispersions, followed by their delivery to the CPB NC surface, defect‐site recovery, and defect prevention. The perovskite‐structure healing process through the DDS‐type process (with Ag NCs as the drug) is analyzed by a combination of theoretical calculations (with density functional theory) and experimental analyses. The proposed DDS‐inspired healing strategy significantly enhances the optical properties and stability of perovskite NCs, enabling the fabrication of white light‐emitting diodes.
Thermal Induced Conversion of CoFe Prussian Blue Analogs Nanocubes Wrapped by Doped Carbon Network Exhibiting Fast and Stable Potassium Ion Storage as Anode
Authors: Ouyang Yujia , Li Ping , Ma Yu , Wei Jiawei , Tian Weiqian , Chen Jingwei , Shi Jing , Zhu Yue , Wu Jingyi , Wang Huanlei 
Published: December 2023

AbstractPrussian blue analogs (PBAs) show great promise as anode materials for potassium‐ion batteries (PIBs) due to their high specific capacity. However, PBAs still suffer from the drawbacks of low electronic conductivity and poor structural stability, leading to inadequate rate and cyclic performance. To address these limitations, CoFe PBA nanocubes wrapped with N/S doped carbon network (CoFe PBA@NSC) as anode for PIBs is designed by using thermal‐induced in situ conversion strategy. As expected, the structural advantages of nanosized PBA cubes, such as abundant interfaces and large surface area, enable the CoFe PBA@NSC electrode to demonstrate superior rate properties (557 and 131 mAh g−1 at 0.05 and 10 A g−1) and low capacity degradation (0.093% per cycle over 1000 cycles at 0.5 A g−1). Furthermore, several ex situ characterizations revealed the K‐ion storage mechanism. Fe+ and Co0 are generated during potassicization, followed by a completely reversible chemical state of iron while some cobalt monomers remained during depotassication. Additionally, the as‐built potassium‐ion hybrid capacitor based on CoFe PBA@NSC anode exhibits a high energy density of 118 Wh kg−1. This work presents an alternative but promising synthesis route for Prussian blue analogs, which is significant for the advancement of PIBs and other related energy storage devices.