bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling Crucial Proteins in Zone 2 of the Human Protein Interaction Network: Implications for Cancer Research and Therapeutic Targeting
Authors: Fadhal Emad 
Published: December 2023

Background:
Protein-protein interaction networks are of great importance for understanding the complexity of biological processes and diseases, including cancer. However, detecting key proteins that regulate and mediate biological processes within these networks can be challenging due to their enormous size and complexity. Identification of these important proteins is of great importance for identifying therapeutic targets and elucidating molecular mechanisms in various types of cancer.

Aims:
The aim of this study was to investigate the importance of zone 2, the central zone of the protein interaction network in humans, and to identify potential therapeutic targets for common proteins expressed in different types of cancer.

Method:
We analyze zone 2 of the human protein interaction network and identify proteins within the network that function as key regulators or mediators of biological processes. We use multiple biological databases to collect data on protein-protein interactions and cancer types. We analyze the data to obtain promising proteins for different types of cancer.

Results:
Our analysis identified several important proteins in several types of cancer. These proteins play important roles in regulating biological processes within the network.

Conclusion:
Our approach effectively identifies essential proteins within protein-protein interaction networks across multiple cancer types. Furthermore, the identification of key proteins in zone 2 of the human protein interaction network will provide new insights into the molecular mechanisms underlying various cancer types and pave the way for new therapeutic targets.
A Novel Smartphone App for Self-Monitoring of Neonatal Jaundice Among Postpartum Mothers: Qualitative Research Study
Authors: Moosa Aminath Shiwaza , Ngeow Alvin Jia Hao , Yang Yuhan , Poon Zhimin , Ng Ding Xuan , Yi Ling Eileen Koh , Tan Ngiap Chuan 
Published: December 2023

Abstract

Background
Neonatal jaundice (NNJ) or hyperbilirubinemia is a ubiquitous condition in newborn infants. Currently, the transcutaneous bilirubinometer is used to screen for NNJ in health care facilities, where neonates need to be physically present (ie, a centralized model of care for NNJ screening). Mobile health (mHealth) apps present a low-cost, home-based, and noninvasive system that could facilitate self-monitoring of NNJ and could allow mothers the convenience of screening for NNJ remotely. However, end users’ acceptability of such mHealth apps is of fundamental importance before the incorporation of such apps into clinical practice.

Objective
The study aimed to explore the perception of postpartum mothers toward self-monitoring of NNJ using a novel mHealth app.

Methods
Mothers attending video consultations for early postpartum care at 2 Singapore primary care clinics watched an instructional video for a hyperbilirubinemia-screening mHealth app (HSMA). An independent researcher used a semistructured topic guide to conduct in-depth interviews with 25 mothers, assessing their views on HSMAs. All interviews were audio recorded, transcribed verbatim, and checked for accuracy before data analysis. Two researchers independently analyzed the transcripts via thematic analysis. Data were managed using NVivo qualitative data management software.

Results
The identified themes were grouped under perceived usability and utility. Mothers valued the convenience and utility of HSMAs for remote monitoring of NNJ. They appreciated the objectivity the app readings provided compared to visual inspection. However, they perceived that the app’s applicability would be restricted to severe jaundice, were concerned about its accuracy and restriction to the English language, and lacked confidence in using it. Nevertheless, they were willing to use it once its accuracy was proven and when they received adequate guidance from health care professionals. They also suggested including an action plan for the measured readings and clinical signs within the app. Mothers proposed pairing teleconsultations with HSMAs to boost their confidence and enhance adoption.

Conclusions
Mothers were receptive to using HSMAs but had concerns. Multiple languages, proof of accuracy, and resources to guide users should be incorporated into the app in the next phase to increase its successful adoption. Complementing such apps with a teleconsultation service presents a plausible and pragmatic NNJ care delivery model in general practice.
İLK HALKA ARZLARDA DÜŞÜK FİYATLAMA ANOMALİSİ: BORSA İSTANBUL’DA PİYASAYA GÖRE DÜZELTİLMİŞ ANORMAL GETİRİ MODELİ İLE SVFM KARŞILAŞTIRILMASI
Authors: YILMAZ Adem , ABDİOĞLU Nida 
Published: December 2023

Amaç: Şirketler paylarını ilk halka arz yöntemi ile ihraç ederek fon ihtiyacını giderme, kredibilite ve likidite gibi çeşitli avantajlar sağlamaktadır. Bununla birlikte pay senetlerinin düşük fiyatlandırılması gibi halka arz kararını etkileyebilecek bazı dezavantajlar da bulunmaktadır. Bu çalışmanın amacı, Borsa İstanbul’da (BİST) 2005-2020 yılları arası ilk halka arzı gerçekleşen pay senetlerinde düşük fiyatlama olgusunun varlığını test etmektir.
Yöntem: Olay etüdü yönteminin kullanıldığı çalışmada, anormal getiriler piyasaya göre düzeltilmiş anormal getiri modeli ve sermaye varlıkları fiyatlama modeli (SVFM) ile hesaplanmıştır.
Bulgular: Piyasaya göre düzeltilmiş anormal getiri modeli ile SVFM’nin karşılaştırıldığı t-testi sonucunda iki modele göre hesaplanan anormal getiriler arasındaki farkın anlamlı olduğu görülmüştür. Anormal getiri ortalamaları piyasaya göre düzeltilmiş anormal getiri modelinde SVFM’ye göre daha yüksek bulunmuştur. Sektörlere göre anormal getiriler arasında anlamlı bir farklılık olup olmadığını değerlendirmek amacıyla yapılan ANOVA testi sonucunda sektörler arasında düşük fiyatlama açısından anlamlı bir farklılık görülmemiştir.
Sonuç: İki model açısından da düşük fiyatlandırmanın varlığı tespit edilmiştir.
Marriage with the Transfer of a Nasab Guardian to Teungku Dayah According to Islamic Law
Authors: Maghfirah Maghfirah 
Published: December 2023

This research was motivated by a case in the Ingin Jaya District, Aceh Besar Regency, where there was a marriage with the transfer of the nasab guardian to Teungku Dayah in accordance with Islamic law. A wakalah or transition contract is essentially a contract used by someone if the guardian of the nasab marriage needs someone else to do something that he cannot do himself and asks someone else to do it with the consent of both parties. Therefore, the researcher is interested in researching what factors led to the transfer of marriage guardianship from the nasab guardian to Teungku Dayah and what Islamic Law provisions mean for the process of transferring the nasab marriage guardian to Teungku Dayah. The research methods used are field research and library research. The results of the research state that provisions in Islamic law allow transition or representation to Teungku Dayah due to various factors including ungodly abandoning Allah SWT commands such as abandoning obligatory prayers, carrying out Allah SWT prohibitions such as disobedience, gambling, nervousness or embarrassment in public, old age such as being senile, his eyes are blurry, and his body is shaking. Furthermore, the view of Islamic law regarding the process of transferring the guardian of the nasab marriage to Teungku Dayah is a process that must be gone through, namely that the guardian of the nasab and the person who replaces the position of guardian of the nasab must carry out a wakalah contract before the marriage takes place. The legal transition was carried out because it was seen as a form of mutual help based on goodness and piety commanded by Allah SWT and His messenger.
Actual Research on the Values of the Youth of Europe and Russia in the Context of the Socio-Cultural Mentality’s Theory of Pitirim Sorokin The Popularity of K-Pop Culture in Russia: Good or Evil? The Case of BTS
Authors: Bayer Ju. P. , Romanov V. D. 
Published: December 2023

The historical perspective deals with the comparative study of social values and cultural dimensions as a direction of social sciences, and demonstrates the results of empirical research on the values of young people in Russia and Europe. In their study, the authors relied on the approach of the Russian-American sociologist P. A. Sorokin in defining the mentality of contemporary youth. In characterising the mentalities, Pitirim Sorokin highlighted the main parameters of mentality diagnosis, which were integrated and adapted by the authors into the research toolkit. The aim of the study was to identify the values of student youth on the basis of a comparativist approach. Based on the results of the study, the authors, continuing Pitirim Sorokin’s theory of the fluctuation of mentalities, characterize the modern mentality of young people according to the criteria highlighted by the classic sociologist. In organizing the study, the authors drew on the findings of past and ontemporary sociologists on the onset of the transition from the dominance of one mentality in Western culture to new models of perception and attitudes in society; this position formed the basis of one of the hypotheses of the study. Based on the results of the processing of the collected data, it was possible to identify the basic components of the values of contemporary European and Russian youth, which include equally material and “spiritual” priorities, whereas separately such values dominate in the vast minority.
Trends in the Implementation of the ESG Agenda by Mining Companies in Russia
Authors: Konyagina M. N. , Sagitov D. 
Published: December 2023

By examining the current positions of Russian mining companies in the field of sustainable development, the authors set a goal to identify trends in the implementation of the ESG agenda of mining companies in Russia. To achieve it, information on emissions of air pollutants and greenhouse gases was systematized and summarized, as well as the most ambitious companies in the implementation of the agenda and with the most successful experience in implementing ESG were identified. The study used a wide range of materials: scientific articles, statistics and reports published by mining companies. Based on the results of the work done, it was concluded that Russian mining companies follow the tasks set for them to implement the ESG agenda, despite the complexity of geopolitics.
AI Policy as a Field of Study: Preliminary Findings from a Bibliometric Analysis
Authors: Bolgov R. V. 
Published: December 2023

The aim of the article is to contribute to a better understanding of the literature in the field of artificial intelligence (AI) policy and to demonstrate the possibilities of using software for automated processing of information arrays loaded from bibliographic databases for bibliometric analysis of this complex interdisciplinary research field.Methods. First, we use a descriptive analysis of articles and authors to define what “AI policy” is and the main directions of this research field. Secondly, we define the conceptual structure of the research field using bibliometric analysis, which allows us to create a map of the main and especially important topics of study. These themes have been analyzed and grouped. Third, we identify areas for future research.Results. In total, 1545 publications were analyzed from the Google Scholar database for the period 1968–2022. The obtained results testified to the possibility of effective use of special software for the scientific trends analysisConclusion. The qualitative interpretation of the results made it possible to propose several areas of research that should be developed in the future. The first notable observation is the paucity of research examining AI policy and its quality in the face of geopolitical shock. The second research observation is that there is little research on the effects assessment of AI policies.
Penerapan Digital PBL Berbasis Flashcard dalam Meningkatkan Kemampuan adaptasi Literasi dan Perkembangan Kognitif di Kelas Besar
Authors: Rif’atul Amaliah Novia , Anwar Khoirul 
Published: December 2023

Penelitian ini bertujuan menguji efektivitas penerapan digital PBL berbasis flashcard dalam meningkatkan kemampuan adaptasi literasi dan perkembangan kognitif di kelas besar. Pada penelitian ini digunakan metode kuantitatif dan kualitatif model concurrent. Proses pengumpulan data kuantitatif melalui pretest dan posttest, sedangkan pengumpulan data kualitatif melalui observasi dan interview pada 30 peserta didik kelas V UPT SDN 49 Gresik dipilih menggunakan purposive sampling. Hasil pretest dan posttest dianalisis melalui uji normalitas sehingga menunjukkan tingkat signifikansi sebesar 0,106>0.05 dan 0,058>0.05 yang berdistribusi normal, selanjutnya data diuji melalui uji T-test dengan hasil tingkat signifikansi 0.00 yang menunjukkan peningkatan prestasi belajar peserta didik dilihat melalui meningkatnya hasil rata-rata pretest dan posttest. Hasil rata-rata pretest sebanyak 66,17 sedangkan hasil rata-rata posttest sebanyak 77,83. Kenaikan sebesar 11,66 menunjukkan peserta didik mengalami peningkatan pemahaman pada materi pembelajaran. Peningkatan literasi peserta didik diamati dari observasi dan interview. Hasil observasi menunjukkan peserta didik dapat menemukan solusi dari permasalahan pada flashcard. Hasil interview menunjukkan peserta didik memiliki pemahaman yang baik mengenai literasi dan mampu menerapkannya pada proses pembelajaran. Peserta didik dapat menyebutkan norma tertulis maupun tidak tertulis. Berdasar hasil penelitian, disimpulkan bahwa pembelajaran menggunakan metode digital PBL berbasis flashcard merupakan pembelajaran yang efektif dalam meningkatkan kemampuan kognitif dan literasi peserta didik.
ANALISIS PEMANFAATAN SERBUK KAPUR DAN TANAH LEMPUNG SEBAGAI BAHAN SUBTITUSI PAVING BLOCK BERDASARKAN SNI 03-0691-1996
Authors: Hanafi Taufig , Amran Yusuf , Oktavia Chica 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh serbuk kapur terhadap sifat fisik dan mekanis paving block. Tanah yang dipakai berasal dari Gading Rejo, Pesawaran. Penelitian ini menggunakan campuran serbuk kapur 10% dan 20% sebagai pengganti semen. Benda uji yang digunakan berbentuk persegi panjang dimensi 20 x 10 x 6 cm, dan balok 5 x 5 x 6 cm. Pengujian daya serap air, beban kejut, kuat tekan dilakukan setelah dilakukan proses pemanasan dengan oven pada suhu 100˚C, 125˚C, 150˚C selama 120 menit, 100 menit, 60 menit. Hasil pengujian dari penelitian ini menunjukkan bahwa, pada penambahan 10% serbuk kapur daya serap air paving block 27,653%, beban kejut dengan suhu 125˚C dan waktu 100 menit sebesar 105,95 joule, dan kuat tekan tertinngi pada suhu 100˚C waktu 120 menit sebesar 32,351 Kg/cm². Pada campuran 20% serbuk kapur terjadi kenaikan pada daya serap air, pada kuat tekan terjadi kenaikan pada suhu 125˚C waktu 100 menit sebesar 31,003 Kg/cm², dan pada beban kejut terjadi penurunan. Hasil pengujian daya serap air dan kuat tekan belum memenuhi standar paving block sesuai SNI 03-0691-1996
Foreign experience of implementation of certain forms of public control over police activities and ways of its implementation in Ukraine
Authors: Shevchuk V. 
Published: December 2023

In order to develop an effective national model of public control over police activities in general and to clarify the main aspects of interaction between the public and the police, the article analyzes the foreign experience of public control over police activities and highlights the ways of its implementation in Ukraine.
The systematic basis of the study of forms of public control over police activities in foreign countries and the methods of their implementation is the principle of selectivity, the basis of which is the study of the international experience of politically, economically, and socially successful countries (France, Great Britain, Germany, the USA, Canada, Japan) in in which the public is actively involved in police activities.
As a result of the study, separate ways of implementing foreign experience in public control of police activities were proposed, in particular, the expediency was determined: to define and normatively establish the grounds, forms and methods of involving citizens in the protection of public order in the new Law of Ukraine «On Public Participation in the Protection of Public Order», which needs development and adoption; to regulate in the Law «On the National Police» one of the forms of public control over police activities - participation of citizens on a voluntary basis in the protection of public order, detection, recording and investigation of the circumstances of commission of offenses and crimes and taking measures to eliminate the causes and conditions of their commission; to develop and adopt state and municipal programs for public participation in public order and security, which should determine effective, not formal grounds, forms and procedures for such activities, including establishing the mechanism of interaction between the police and the public in this area; to create the Association for the Support of Police Activities as a public organization created on a voluntary basis by citizens to participate in the activities of the police, including to improve the provision of police services to the population and public control over police activities.
Use of flexible intramedullary rods for fixation of femoral fractures in eight dogs
Authors: Church Edgar M. , Schrader Steven C. 
Published: December 2023

Summary
High-density, polysulfone rods were used to repair 4 comminuted and 4 short-oblique, mid-diaphyseal femoral fractures in 8 dogs. Bony union was achieved in 2 dogs at 10 and 12 weeks after surgery. In one dog, the femoral fracture was healing when amputation of the limb became necessary because of sciatic nerve damage secondary to an ipsilateral pelvic fracture. In a fourth dog, fracture repair resulted in nonunion, despite normal clinical function at 18 months after surgery. In the remaining 4 dogs (50%), the rods failed at 3.5, 4, 6, and 22 weeks after surgery. These fractures were then stabilized by use of other methods. Although several factors may have contributed to failure of the rods, multiple autoclaving of the thermoplastic implants may have caused embrittlement and subsequent breakage.
Clinical evaluation of intertrochanteric osteotomy for treatment of dogs with early-stage hip dysplasia: 37 cases (1980-1987)
Authors: Braden T. D. , Prieur W. D. , Kaneene J. B. 
Published: December 2023

Summary
Between May 1980 and May 1987, intertrochanteric osteotomy was performed on 43 hips of 37 dogs (6 bilateral procedures) with early-stage hip dysplasia, with the objectives of improving hip biomechanics and reducing discomfort. Clinical evaluation consisted of: questionnaire, and/or orthopedic examination, and/or report from owner(s) via telephone. At least 1 form of evaluation was conducted for 42 of 43 hips (98%). On the basis of orthopedic examination findings, 27 of 33 hips (84%) were functionally good or normal at postoperative month 15 (on average). On the basis of owner report, 19 of 28 hips (68%) were functionally good or normal at postoperative month 11 (on average). On the basis of questionnaire data, 17 of 24 hips (70%) were functionally good or normal at postoperative year 1. Before surgery, only 11 of 37 hips (30%) had been evaluated as functionally good or normal. Of 36 owners, 33 (91.6%) reported that they would have the procedure performed again if the circumstances were the same. From the good to excellent clinical results, we concluded that intertrochanteric osteotomy is a beneficial treatment for dogs with early-stage hip dysplasia.
Plasma von Willebrand factor concentration and thyroid function in dogs
Authors: Avgeris Sophia , Lothrop Clinton D. , McDonald T. P. 
Published: December 2023

Summary
Plasma von Willebrand factor antigen concentration was determined in 15 dogs with suspected hypothyroidism, in 1 dog with hyperthyroidism, and in 14 euthyroid dogs. The mean ± sem von Willebrand factor:antigen concentration in hypothyroid dogs (47.1% ± 12.6%) was significantly decreased (P <0.0005), compared with that in euthyroid dogs (94.7 ± 5.6%). Four hypothyroid dogs were given thyroxine for 1 month and all 4 had an increase in von Willebrand factor:antigen concentration. The plasma von Willebrand factor:antigen concentration was 200% in the hyperthyroid dog. Seemingly, reduced concentrations of plasma von Willebrand factor:antigen can be found in dogs in association with congenital von Willebrand disease or with von Willebrand disease acquired through hypothyroidism.
Coverage of sixty core veterinary medical journals by ten indexing and abstracting tools
Authors: Veenstra R. J. , Wright J. C. 
Published: December 2023

Summary
Ten indexing and abstracting reference sources were examined for their coverage of 60 core veterinary medical journals. The costs of the indexes also were compared. Coverage of the 60 core veterinary journals ranged from 8 of 60 journals by Current Contents—Life Sciences to 57 of 60 by Index Veterinarius. Based on yearly costs, format, and coverage of the 60 core veterinary journals, Small Animal Practice and the 2 editions of Veterinary Reference Service were determined to be the most useful for private practitioners. The Index Veterinarius gives the most complete coverage of the core veterinary journals for veterinary research workers who have access to a library.
Atracurium administration, as an infusion, to induce neuromuscular blockade in clinically normal and temporarily immune-suppressed cats
Authors: Ilkiw J.E. , Forsyth S.F. , Hill T. , Gregory C.R. 
Published: December 2023

Summary
Atracurium besylate, a nondepolarizing neuromuscular blocking agent, was administered by infusion to 10 cats that were anesthetized with isoflurane and oxygen to allow transplantation of a myocutaneous flap. Five of the cats were given cyclosporine (20 mg/kg of body weight, po, q 12 h in divided doses) for 2 days prior to anesthesia, and prednisolone (0.25 mg/kg, po) on the morning of surgery. The other 5 cats were not given either drug. Neuromuscular blockade was assessed, using the train-of-four stimulation, and throughout surgery, the infusion rate was adjusted to maintain the first-twitch response (T1) at 90 to 95% depression from baseline. At completion of surgery, atracurium was discontinued, and the infusion rate and the time for recovery (the time for the train-of-four ratio to increase from 50 to 75%) were recorded. Once the train-of-four ratio had been stable for 10 minutes, edrophonium (0.5 mg/kg), a cholinesterase inhibitor, was administered iv, and neuromuscular blockade was monitored for another 10 minutes.
Mean (±sd) duration of the atracurium infusion was 302.1 ± 70.5 minutes for the control group and was 323.9 ± 61.7 minutes for the cats given cyclosporine and prednisolone. In the cats of the control group, the infusion rate required to induce 90 to 95% T1 depression from baseline was 3.7 ± 0.7 μg/kg/min. This rate was not significantly different from that of 2.8 ± 1.2 μg/kg/min in cats given cyclosporine and prednisolone. Significant difference in recovery time was not evident between the control group and the treated group (6.4 ± 4.5 minutes vs 6.2 ± 2.5 minutes).
In this study, administration of atracurium by continuous infusion proved to be a suitable method of obtaining neuromuscular blockade for a prolonged period. Administration of cyclosporine and prednisolone did not affect the infusion rate of atracurium required to depress the first twitch by 90 to 95% and did not affect return of neuromuscular function.