bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sepsis Management in Low- and Middle-Income Countries: A Systematic Review
Authors: Jenson Alexander , Loevinsohn Gideon , Lukacs Teagan , Osula Valerie , Jalbout Nour Al , Rao Aditi , Lorenz Kathryn , Chipendo Portia , Hansoti Bhakti 
Published: January 2024

Abstract

Background Optimal sepsis management in low-resource settings is the subject of active debate. Given resource limitations, prevalent co-morbidities, and unique infectious epidemiology, resuscitation strategies conceived in resource-rich settings may be difficult to apply more broadly. Evidence from low- and middle-income country (LMIC) settings is disparate and frequently discordant. We sought to synthesize the available data. Methods A systematic search of sepsis resuscitation interventions in LMIC was performed in PubMed, EMBASE, Scopus, Global Health Library databases, and the gray literature in accordance with PRSIMA guidelines. Studies were included if they defined a fluid or antibiotic intervention and measured the effect on in-hospital mortality for patients with undifferentiated sepsis. Studies were categorized based on the volume of fluid administered and the time to antibiotic administration. Results The search yielded 22,088 unique articles, of which 26 studies, encompassing 15,667 patients met the inclusion and were included. Over half the studies (14/26) evaluated the effect of fluid administration on mortality and found a trend toward increased mortality when more than 2 L were administered in the first 6 hours, while 1–2 L was associated with reduced mortality. Among the 15 studies evaluating the impact of antibiotic timing, administration within 3 hours was associated with reduced likelihood of in-hospital mortality. However, there was wide heterogeneity across study methodologies, outcomes, and resource variation. Conclusion Synthesis of the available data suggests that a judicious fluid strategy (between 1 and 2 liters within the first 6 hours) and early antibiotic administration are the most appropriate strategies for undifferentiated sepsis. More research is needed, especially in rural low-resource settings where we found a dearth of available research.
Cognitive Demands and Strategic Preparedness of Novice English Teachers for ELL Instruction in Zhejiang province, China
Authors: li Ruyang , Shah Mohamed Ismail Ahamad 
Published: January 2024

Abstract
This study explores the cognitive challenges and preparedness of novice English language teachers in Zhejiang Province, China, for teaching English Language Learners (ELLs). Addressing the gap in research on the application of theoretical frameworks in this context, the qualitative descriptive research involved 15 novice educators through interviews, observations, and document analysis. It is grounded in Illeris' Contemporary Learning Theory and Vygotsky's Sociocultural Theory. Key findings include the identification of significant cognitive challenges in addressing diverse learning needs and knowledge gaps among ELLs. The study also highlights the effective use of metacognitive techniques and scaffolding in ELL instruction. It underscores the need for comprehensive teacher training in China, advocating for programs that go beyond linguistic skills to include varied pedagogical strategies, catering to the complex requirements of ELL students.
A web-based knowledge database to provide evidence-based information to cancer patients: Utilization within the PIKKO study
Authors: Schneider Nico , Altmann Uwe , Brandt Florian , Hübner Jutta , Strauss Bernhard , Keinki Christian 
Published: January 2024

Abstract

Purpose
In the context of cancer, a high amount of dangerous disinformation exists online. High quality information websites are less visible in online searches, and profit-driven websites have lower quality. As part of the PIKKO project, a web-based knowledge database (WDB) was used to provide cancer patients with quality-assured, evidence-based information. This paper aims to provide information about the usage (Who? How? What?) and the effects regarding health literacy of WDB.
Methods
A patient survey and automatically generated logfile data were evaluated. Two user groups, patients and patient navigators (PNs), were compared.
Results
The 13 PNs were responsible for 1/3 of all accesses over the entire duration of the project. The 413 patients used WDB twice on average and spent an average of 12 minutes per session online (PNs: 9 minutes per session, more frequently). The top 3 topics of interest were ‘therapy’, ‘nutrition’ and ‘carcinogenesis’ for the patients, and ‘therapy’, ‘naturopathy’ and ‘legal regulations/support’ for the PNs. Of the patients surveyed, 69% said that WDB was helpful in making informed decisions, 76% found the information they wanted and 90% thought WDB was an appropriate way to provide information.
Conclusion
Our WDB provided important information about cancer and its treatment on a digital way both, to patients and PNs. In routine cancer care, the WDB can improve health literacy and informed decision-making.
Trial registration:
This study was retrospectively registered in the German Clinical Trial Register under DRKS00016703 (21 Feb 2019, retrospectively registered). https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00016703
Pregnancy-Associated Events in Prognosis and Outcome of Lymphangioleiomyomatosis: A Single-Center Retrospective Analysis
Authors: Jingye Tai , Shihua Liu , Xinping Yan , Zixin Fan , Luantai Huang , Weilin Wang , Yingxin Pan , Hongyuan Huang , Zhen Zhao , Beini Xu , Jie Liu 
Published: January 2024

Abstract

Background: Lymphangiomyomatosis (LAM) is an uncommon condition that primarily impacts women in their reproductive years. Current guidelines discourage pregnancy behavior in women with LAM because to the belief that it raises the risk and does not result in favorable pregnancy outcomes. Pregnancy events have been linked to a higher likelihood of developing pneumothorax and chylothorax, as well as an acceleration in the deterioration of lung function. Currently, there is a deficiency of extensive clinical trials investigating the impact of pregnancy on LAM.Methods: The study conducted an integrative analysis by collecting data from the LAM patient registry at the First Hospital of Guangzhou Medical University in Guangzhou, China, as well as from LAM patient organizations in South China. Additionally, the study searched the MEDLINE, Scopus, Embase, and Cochrane Central databases for six relevant clinical articles using the keywords "lymphangiomatosis" and "pregnancy". Retrieve scholarly publications for systematic assessment.Results: The study had a total of 133 patients diagnosed with lymphangiomatosis. Out of the total number of patients, 91 individuals (68.4%) experienced irregularities in their menstrual cycles. A single patient was identified with lymphangioleiomyomatosis (LAM) after experiencing pneumothorax during pregnancy. Out of the 12 instances of pregnancy, LAM was identified before conception.One case of dyspnea, one case of renal abnormalities, and one case of tubal pregnancy were identified. Abnormal pregnancy events had place in 25 out of the 173 pregnancies (14.5%) that happened before the diagnosis of LAM. The analysis included six more studies, which reported an incidence of 13.47% for pneumothorax during pregnancy with LAM, 8.30% for dyspnea, and 3.32% for other respiratory abnormalities. Among the five studies that documented aberrant pregnancies, a total of 73 miscarriages (14%), 83 abortions (16%), and 12 other pregnancy outcomes (2%) were reported.Conclusions: The elevated incidence of monthly irregularities in individuals with lymphangiomatosis may be attributed to the use of sirolimus and the variable levels of estrogen in patients with lymphangiomatosis. Pregnancy significantly increases the likelihood of experiencing a sudden worsening of lymphangiomatosis-associated pulmonary disease (LAM). Pregnancy might cause a sudden worsening of LAM. LAM exhibits a substantial prevalence of unfavorable reactions during pregnancy, resulting in unfavorable pregnancy results. Consequently, it is advised against getting pregnant in individuals with LAM.
Study strategies and exam outcomes in medical education: Insights from renal physiology
Authors: Heltne Sofie Fagervoll , Hovdenakk Sigrid , Kvernenes Monika , Tenstad Olav 
Published: January 2024

Abstract

Background
Efficient learning strategies and resource utilization are critical in medical education, especially for complex subjects like renal physiology. This is increasingly important given the rise in chronic renal diseases and the decline in nephrology fellowships. However, the correlations between study time, perceived utility of learning resources, and academic performance are not well-explored, which led to this study.
Methods
We conducted a cross-sectional study by inviting second-year medical students from the University of Bergen, Norway, to participate in a survey on their preferred learning resources and the time dedicated to renal physiology in comparison to other subjects. The students' responses were then correlated with their end-of-term exam scores to identify effective learning behaviors.
Results
The study revealed no significant correlation between time spent studying and overall academic performance, highlighting the importance of study quality over quantity. Preferences for active learning resources, such as Team-Based Learning, interactive lessons and formative assessments, were positively correlated with better academic performance. A notable correlation was found between students’ valuation of teachers’ professional competence and their total academic scores. Conversely, perceived difficulty across the curriculum and reliance on self-found online resources in renal physiology correlated negatively with academic performance. 'The Renal Pod', a locally produced renal physiology podcast, was popular across grades. Interestingly, students who listened to all episodes once achieved higher exam scores compared to those who listened to only some episodes, reflecting a strategic approach to podcast use. Textbooks, while less popular, did not correlate with higher exam scores. Despite the specific focus of renal physiology, learning preferences are systematically correlated with broader academic outcomes, reflecting the interconnected nature of medical education.
Conclusion
The quality and strategic approach to learning, rather than the quantity of study time, significantly impacts medical students' academic performance. Successful learners in preclinical medical education, particularly in complex subjects such as renal physiology, tend to be proactive, engaged, and strategic, valuing expert instruction and active participation in learning activities. The findings support the integration of student-activating teaching methods and assessments that reward deep learning, with implications extending beyond renal physiology.
Metal-containing zeolite composites with separated phases as catalysts for hydroisomerization of linear hexane
Authors: Voloshyna Yuliya G. , Pertko Olexandra P. , Yakovenko Angela V. , Povazhnyi Volodymyr A. , Patrylak Lyubov K. 
Published: January 2024

Abstract

In this work, composite catalytic systems of natural mordenite and synthetic MFI-type zeolite containing Pd and Ni nanoparticles (0.5–1.5% by weight in total) were prepared by mechanical mixing (1:1), optionally with the addition of α- or γ-Al2O3 as a binder. The samples were examined using IR spectroscopy, X-ray diffractometry, transmission electron microscopy, low-temperature nitrogen ad(de)sorption, and tested in the model reaction of n-hexane hydroisomerization in a micro-pulse mode to determine the effect of composition on the peculiarities of linear alkane transformation. It has been shown that in the obtained catalytic systems, modifications of aluminum oxide used as a binder affect the effectiveness of catalysts in the conversion of n-hexane. This is explained by the different dispersity of α- and γ-Al2O3 particles, which causes different porosity of the result composites, and possibly by the interaction of zeolite acid sites with binder acid sites, which leads to changes in their characteristics depending on the modification of aluminum oxide. In this respect, α-Al2O3 proved to be better than γ-Al2O3. Synergy between the two zeolite components in the formation of isomers has been found out, which was more effective in samples with an isotropic distribution of zeolite phases. In the applied micro-pulse reaction mode, the composite catalyst prepared without a binder was the best, showing a significantly lower temperature of the maximum yield of isomerization products and a high yield of dimethyl-branched isomers, and having selectivity for n-hexane isomers at the level of high selectivity of the Pd-containing component.
Male Sexual Dysfunction in Patients with Chronic Kidney Disease: A Cross-Sectional Study
Authors: Fu Ruijie , He Peihua , Hong Hongwei , Liang Yichun , Wang Wen , Yuan Shaoying , Liu Lichang 
Published: January 2024

Abstract

(1) Background: Sexual dysfunction is common in male with chronic kidney disease (CKD), but the prevalence and association between CKD and sexual dysfunction, especially PE, remain to be investigated in China;
(2) Objective: To investgate the prevlence and association between CKD and sexual dysfunction in male patients in China.;
(3) Methods: A cross-sectional, non-interventional, observational study was conducted at single center and 72 male patients with CKD were selected. The questionnaire included socio-demographic information, a 5-item version of the International Index of Erectile Function (IIEF-5), Premature Ejaculation Diagnostic Tool (PEDT) in Chinese version, the Patient Health Quentionnnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7). SPSS software 25.0 was used for data analysis;
(4) Results: 56.9% of 72 CKD patients had erectile dysfunction (ED) and the prevalence of premature ejaculation (PE) was 29.2%. Multiple factors such as vascular lesions and neuropathy of complications, psychological factors, medications were found to be associated with sexual dysfunction in CKD patients;
(5) Conclusion: Sexual function is common among CKD male patients, which can not be divorced from multifactors. Clinicians should pay more attention to sexual dysfunction in male patients with CKD and the pathogenesis should be further studied.
Identification of RAB3IP as a novel oncogene related to ovarian cancer
Authors: Li Xiaohao , He Qian , He Aiqin 
Published: January 2024

Abstract
Obejctive:
The incidence of ovarian cancer ranks third among gynecological malignancies, after cervical cancer and endometrial cancer. However, the mortality rate of ovarian cancer has always been the highest. The pathogenesis of ovarian cancer is not fully understood because the ovary is located deep in the pelvis, the onset of the disease is relatively insidious, and ovarian cancer is usually diagnosed at an advanced stage. The aim of our study was to explore new biomarkers and possible therapeutic targets for ovarian cancer.
Methods
We used public data from the cancer genome atlas TCGA and GTEx to explore the expression level of the RAB3IP gene in ovarian cancer patients.At the same time, we analyzed the correlation between the RAB3IP gene expression and patient survival,and use ROC curve to predict its clinical efficacy.We validated the level of RAB3IP in ovarian cancer tissue using WB and q-PCR. We used cck-8, wound-healing assay and colony formation assay to verify its potential biological function in ovarian cancer.By using molecular docking technology to predict potential drug targets.Pathway enrichment analyses was used to analyze the mechanism of the RAB3IP in the occurrence and development of ovarian cancer.
Results
In this study, we found that the expression of RAB3IP in ovarian cancer is high by bioinformatics and cell biology and verified it with tissue samples. The promotion of RAB3IP on the proliferation and migration of ovarian cancer was confirmed by cck-8, wound-healing assay and colony formation assay, and RAB3IP-related genes were enriched for their possible functions, which were believed to be involved in the immune and microenvironmental regulation of ovarian cancer to some extent.The expression level of RAB3IP is also significantly correlated with the prognosis of ovarian cancer. In addition, we performed drug target prediction of RAB3IP, identifying Austocystin D and Belinostat as potential target drugs that may play a role, and used molecular docking for preliminary validation.
Conclusion
All these results provide preliminary evidence that RAB3IP can be used as a new ovarian cancer biomarker to develop new therapeutic targets.
The Hemoglobin, albumin, lymphocyte, and platelet(HALP) score is associated with severe renal tubular atrophy/interstitial fibrosis in IgA nephropathy
Authors: Liang Xiaoli , Jiang Xue 
Published: January 2024

Abstract

Objective
This study was performed to investigate the relationship between hemoglobin, albumin, lymphocyte and platelet (HALP) score and Oxford classification severe tubular atrophy/interstitial fibrosis (T2) in IgA nephropathy (IgAN).
Methods
The clinical data and pathological findings of patients with IgA nephropathy diagnosed through renal biopsy at Hangzhou Hospital of Traditional Chinese Medicine between June 1, 2019 and May 31, 2022 were retrospectively collected and analyzed. The HALP score was calculated as hemoglobin (g/L)× albumin (g/L)× lymphocytes (/L)/ platelets (/L). According to the quartile of HALP scores in the study population, the subjects were divided into four groups: Quartile 1 (< 30.72), Quartile 2 (30.72-39.97), Quartile 3(39.97-53.25) and Quartile 4(>53.25). According to the extent of tubular atrophy/interstitial fibrosis, patients were categorized into mild to moderate injury (T0+T1, ≤50%) and severe injury (T2, > 50%). The relationship between HALP score and severe tubular atrophy/interstitial fibrosis was investigated using Spearman's rank correlation coefficient, logistic regression analysis, restricted cubic splines (RCS), and receiver operating characteristic (ROC) curve analysis.
Results
A total of 895 patients diagnosed with IgAN were included in this study, with an average age of 40.97±12.261 years. Among them, 384 (42.9%) were male and 61 (6.8%) exhibited severe tubular atrophy/interstitial fibrosis. Multifactorial logistic regression analysis revealed that HALP independently influenced T2 (OR=0.952, 95%CI: 0.923-0.982, P=0.002). Compared to Quartile 1, patients in Quartile 4 exhibited a significantly reduced risk of T2 (OR=0.205, 95%CI: 0.058-0.722, P=0.014). Restricted cubic splines analysis revealed a linear inverse association between HALP and T2 risk (nonlinear P=0.896). Furthermore, the receiver operating characteristic curve demonstrated that HALP possessed predictive value for T2 (AUC=0.693, Jorden index = 0.324), and the cut-off value of HALP score is 36.54.
Conclusion
The risk of severe renal tubular atrophy/interstitial fibrosis is higher in IgAN patients with low HALP. HALP less than 36.54 May reduce the risk of severe tubular atrophy/interstitial fibrosis.
Ant Lion Optimization Algorithm (ALOA) Based Secure Vm Allocation Strategy for Protecting Against Co-Residence Attack in Energy Efficient Cloud
Authors: Veena V , Periyasamy P 
Published: January 2024

Abstract
Virtual machines (VMs) with fluctuating resource requirements are hosted on servers with various configurations, which constitute the bulk of cloud computing. Furthermore, in a networked environment, co-located VMs are susceptible to co-resident attacks (CRA). Degradation in security and performance may result from these two problems, which can also lead to assaults on the service and inconsistent utilization of resources on the server. In this research proposes a safe, workload-balanced, and energy-effective virtual machine allocation technique for preventing such co-residence attacks. To be more precise, formulate the issue as an optimization problem and evaluate and minimize three main aspects: (1) power consumption, (2) security threats, and (3) uneven workloads across several physical servers. Additionally, this research assumes a random number of VMs from various users coming at random times, which necessitates a continuously changing optimization approach in order to account for a real environmental setting. clustering VMs suggest in time windows initially, as the optimization issue is NP-hard. Then, utilize the Ant Lion Optimization Algorithm (ALOA) to determine the best allocation approach for each time window. Extensive findings derived from actual cloud trails confirm the efficacy of the suggested plan.
Docetaxel, Cyclophosphamide, and Epirubicin: Application of PBPK Modeling to Gain New Insights for Drug-Drug Interactions
Authors: Li Tongtong , Zhou Sufeng , Wang Lu , Zhao Tangping , Wang Jue , Shao Feng 
Published: January 2024

Abstract

The new adjuvant chemotherapy of docetaxel, epirubicin, and cyclophosphamide has been recommended for treating breast cancer. It is necessary to investigate the potential drug-drug Interactions (DDIs) since they have a narrow therapeutic window in which slight differences in exposure might result in significant differences in treatment efficacy and tolerability. To guide clinical rational drug use, this study aimed to evaluate the DDI potentials of docetaxel, cyclophosphamide, and epirubicin in cancer patients using physiologically based pharmacokinetic (PBPK) models. The GastroPlus™ was used to develop the PBPK models, which were refined and validated with observed data. The established PBPK models accurately described the pharmacokinetics (PKs) of three drugs in cancer patients, and the predicted-to-observed ratios of all the PK parameters met the acceptance criterion. The PBPK model predicted no significant changes in plasma concentrations of these drugs during co-administration, which was consistent with the observed clinical phenomenon. Furthermore, the verified PBPK models were then used to predict the effect of other Cytochrome P450 3A4 (CYP3A4) inhibitors/inducers on these drug exposures. In the DDI simulation, strong CYP3A4 modulators changed the exposure of three drugs by 0.71–1.61 fold. Therefore, patients receiving these drugs in combination with strong CYP3A4 inhibitors should be monitored regularly to prevent adverse reactions. Furthermore, co-administration of docetaxel, cyclophosphamide, or epirubicin with strong CYP3A4 inducers should be avoided. In conclusion, the PBPK models can be used to further investigate the DDI potential of each drug and to develop dosage recommendations for concurrent usage by additional perpetrators or victims.
Gas-sensitive detection of gas pollutants (CO, CO2, N2O) by single-layer Ti-C2N-V : a DFT study
Authors: liu YAN , boi FILIPPO , zhang leilei , Guo Lifen , Chen Lerui , Ma yanxia , yang biao , Mushtaq Muhammad 
Published: January 2024

Abstract

Recently, the use of efficient gas sensors to detect air pollutants has become one of the key steps for the timely identification of environmental problems. It is very meaningful to develop a gas-sensor that more accurately and efficiently detects certain air pollutants in the environment that are harmful to the human body. In this work, we report on the properties of a novel high-performance gas sensor (Ti-C2N− V) for detection of gas pollutants (CO, CO2, N2O) by using first-principle calculation methods of density functional theory (DFT). The binding energy, recovery time (τ), density of state (DOS), differential charge density, conductivity (σ) and gas sensitivity (S) were investigated. These results provide important insights on the sensitivity of Ti-C2N− V to these three gases is CO2 > CO > N2O. Interestingly, we demonstrate that their sensitivity exhibits values up to 1.61×108, 1.99×1012, and 8.75×1012 at room temperature. These results suggest that the Ti-C2N− V gas-sensor can effectively monitor these three harmful gases, providing a theoretical basis for the practical application of single-layer Ti-C2N− V as a high-efficiency gas sensor for CO, CO2 and N2O.