bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psoralen synergies with zinc implants to promote bone repair by regulating ZIP4 in rats with bone defect
Authors: Liu Meijing , Tan Junlong , Li Shuang , Sun Chaoyang , Liu Xiangning , Yang Hongtao , Wang Xiaogang 
Published: December 2023

Abstract

Background

The regulation of dose-dependent biological effects induced by biodegradation is a challenge for the production of biodegradable bone-substitute materials, especially biodegradable zinc (Zn) -based materials. Cytotoxicity caused by excess local Zn ions (Zn
2+
) from degradation is one of the factors limiting the wide application of Zn implants. Given that previous studies have revealed that delayed degradation of Zn materials by surface modification does not reduce cytotoxicity; in the present study, we explore whether preventing the entry of excess Zn
2+
into cells may can reduce local Zn toxicity by applying Psoralen (PRL) to Zn implants and assessing its ability to regulate intracellular Zn
2+
concentrations.

Methods

The effects of different concentrations of Zn
2+
on cellular activity and cytotoxicity were investigated; briefly, we identified natural compounds that regulate Zn transporters, thereby regulating the concentrations of intracellular Zn
2+
, and applied them to Zn materials. Of these materials, PRL, a natural, tricyclic, coumarin-like aromatic compound that promotes the proliferation and differentiation of osteoblasts and enhances osteogenic activity, was loaded onto the surface of a Zn material using peptides and chitosan (CS), and the surface characteristics, electrochemical properties, and activity of the modified Zn material were evaluated. In addition, the ability of Zn + CS/pPRL implants to promote bone formation and accelerate large-scale bone defect repairs was assessed both in vitro and in vivo.

Results

We determined that 180 µM Zn
2+
significantly induced pre-osteoblast cytotoxicity, and a 23-fold increase in Zrt- and Irt-like protein 4 (ZIP4) expression. We also found that PRL dynamically regulates the expression of ZIP4 in response to Zn
2+
concentration. To address the problem of cytotoxicity caused by excessive Zn
2+
in local Zn implants, PRL was loaded onto the surface of Zn implants in vivo using peptides and CS, which dynamically regulated ZIP4 levels, maintained the balance of intracellular Zn
2+
concentrations, and enhanced the osteogenic activity of Zn implants.

Conclusions

This study reveals the importance of Zn
2+
concentration when using Zn materials to promote bone formation and introduces a natural active ingredient, PRL, that can regulate intracellular Zn
2+
levels, and thus may be clinically applicable to Zn implants for the treatment of critical bone defects.

Graphical Abstract
Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate
Authors: Ma Tingting , Guan Yijia , Feng Jinlun , Yang Yue , Chen Junying , Guo Wenjie , Liao Jianguo , Zhang Yanru 
Published: December 2023

Abstract

Background
Magnesium oxychloride cement has good mechanical properties, but poor water resistance.

Methods

Phytic acid, which can form chelate with Mg
2+
, was used to modify magnesium oxychloride cement, and the effects of phytic acid on the strength, in vitro degradation and biological activity of magnesium oxychloride cement were studied. Based on the preparation of phytic acid modified magnesium oxychloride cement with good water resistance and biological activity, osteoporosis treatment strontium ranelate was loaded on phytic acid- magnesium oxychloride cement, strontium ranelate/phytic acid-magnesium oxychloride cement was prepared.

Results
It was found that the compressive strength of 1.25 wt% phytic acid-magnesium oxychloride cement after soaking in SBF for 28 d could reach 40.5 ± 2.0 MPa, 13.33% higher than that of the control group (when phytic acid was 0 wt%), and the mass loss rate of all ages was lower than that of the control group. The water resistance of magnesium oxychloride cement was effectively improved by phytic acid. After loading with strontium ranelate, the water resistance of 1.25 wt% phytic acid-magnesium oxychloride cement was improved. Cell experiments showed that strontium ranelate could effectively promote cell proliferation and improve the expression of osteoblast-related proteins. When strontium ranelate/phytic acid-magnesium oxychloride cement samples were implanted subcutaneously in rats for 4 w, no obvious inflammatory response was observed, and the material was tightly bound to the surrounding tissues. When bone cement was implanted into rat femur for 4 w, the bone cement was gradually wrapped and absorbed by new bone tissue, which grew from the outside to the inside, indicating that the bone cement containing strontium ranelate/phytic acid-magnesium oxychloride cement had excellent bone-forming ability.

Conclusions
In conclusion, the results indicated that strontium ranelate/phytic acid-magnesium oxychloride cement composite bone cement had a potential application prospect in clinical bone repair.

Graphical Abstract
Associations between circadian, sleep, and mood disturbances in Uruguayan dance students
Authors: Paz Valentina , Coirolo Natalia , Tassino Bettina , Silva Ana 
Published: December 2023

Abstract
Background
Current evidence supports associations between circadian, sleep, and mood disturbances. However, it is still debated to what extent different chronobiological and mood variables act independently or in synergy to impact health.

Methods
This study assesses how these variables interact to affect depressive symptoms and sleep quality in 26 Uruguayan dancers (age=22.27±2.43) training in the morning (n=9) or in the night shift (n=17). Participants completed the Munich Chronotype Questionnaire, the Pittsburgh Sleep Quality Index, and the Beck Depression Inventory-II.

Results
Participants reported high social jetlag (1.58±1.45h), late chronotypes (05:43±01:35), and poor sleep quality (6.77±2.67), while adequate sleep duration (7.10±1.31h) and minimal depression (7.15±3.62), without differences across shifts. Depressive symptoms increased as sleep quality worsened (F(1,21)=20.66, p<0.001, η2=0.50). In addition, we found a marginal interaction between sleep duration and the shift to explain depressive mood (F(1,21)=4.06, p=0.057, η2=0.16), with participants in the morning shift showing higher depressive symptoms with decreased sleep duration. Furthermore, sleep quality deteriorated as social jetlag increased (F(1,20)=14.82, p=0.001, η2=0.43), particularly in more depressed individuals (F(1,20)=24.09, p<0.001, η2=0.55).

Conclusions
Our findings indicate that social, circadian, sleep, and mood variables are inextricably linked in this population of dancers.
Spatial interaction and economic growth: a case of OECD countries
Authors: Evcim Nurgül , Yesilyurt M. Ensar 
Published: December 2023

Abstract
The Solow residual has presented an opportunity to researchers who have been attempting to explain the unexplained share of output. In pursuing this goal, the literature has relied on different models, estimators, and data sets. One such application is spatial models to estimate growth, but it remains rare in the literature. Such models allow us to determine whether the interaction among countries is significant. Additionally, it is possible to observe efforts to mimic different variables among countries thanks to indirect (spillover) effects. Therefore, using spatial models and data sets on founding OECD countries for the period 1996–2019, this article tests alternative weight matrices to clarify the mutual relationship among countries. The findings reveal that spatial models contribute to estimations by improving parametric results. Empirical evidence found that there are spatial interactions among countries. The spillover effect of technology growth is insignificant, while the direct effect is significantly positive. Investment growth is significantly positive except spillover effect. Human capital growth is significantly positive in any sense.
Levels of Robotic Mesopancreas Dissection According to Malignancy and Vascular Anatomy: What Surgeons Need to Know
Authors: Ielpo Benedetto , d’Addetta Maria Vittoria , Anselmo Alessandro , Rosso Edoardo , de Blasi Vito , Sanchez-Velazquez Patricia , Vellalta Gemma , Podda Mauro , Burdio Fernando 
Published: December 2023

Abstract
Introduction
The robotic approach is attracting increasing interest among the surgical community, and more and more series describing robotic pancreatoduodenectomy have been reported. Thus, surgeons performing robotic pancreatoduodenectomy should be confident with this critical step’s potential scenarios.

Materials and Methods
According to Yosuke et al., there are three different levels of mesopancreas dissection. We describe the main steps for a safe mesopancreas dissection by robotic approach.

Results
This multimedia article provides, for the first time in literature, a comprehensive step-by-step overview of the mesopancreas dissection during robotic pancreatoduodenectomy (PD) and its three different levels according to tumor type.

Conclusions
Through the tips and indications presented in this multimedia article, we aim to familiarize surgeons with the mesopancreas dissections levels according to type of malignancy and vascular anatomy.
AMPLIFICATION AS A MEANS OF INTENSIFYING POETIC EXPRESSIVENESS OF SPEECH
Authors: Chaiko Natalja N. 
Published: December 2023

Purpose. This article is devoted to the consideration of amplification as an expressive means of stylistic syntax in the texts of the German Romantics of the 19th century. The author aims to describe various types of enumeration as the main means of amplification, taking into account the nature of the rhythmic expressiveness of a simple sentence and to reveal the entire stylistic potential of enumerative series.
Methods or methodology of the work. The basis of the research is formed by the continuous sampling method in the selection of practical material as well as the method of descriptive linguo-stylistic analysis.
Results. The analysis showed that amplification is a significant means of enhancing the emotional effectiveness of the language of romantic poets. By nominative and verbal enumeration, the effect of monotony, despondency, pressure, elevation, joy and hope is achieved. A special rhythmization of the sentence is created due to the enumerative intonation and rhythm. Along with a certain syntactic uniformity and consistency, there is a dismemberment of a homogeneous enumerative series, which creates a special kind of rhythmic expressiveness.
Practical implications. The results of the research can be used at the lessons of Stylistics of the German Language, Text Interpretation, in seminars on the study of features of the language of German poetry.
STRUCTURAL AND SEMANTIC FEATURES OF THE TITLES IN GRIMMSʼ FAIRY TALES
Authors: Lovyannikova Victoria V. 
Published: December 2023

Grimmsʼ fairy tales are fairy tales collected in German lands and literarily processed by the great germanists Jacob and Wilhelm Grimm. They were included in the collection «Children’s and Household Tales» (German: «Kinder- und Hausmärchen»), originally published in 1812. Thanks to their depth and wonderful plots, these fairy tales have not lost popularity for several centuries and are read with pleasure by adults and children. The purpose of the research was to identify and describe the structural and semantic features of the titles, formulated by the German storytellers.
The relevance. In the modern world of information, the title requires comprehensive research, since it is a key element of the deep part of the text content structure and orients the reader in the world of literature and journalism.
The scientific novelty. In linguistics there is no consideration of the titles in Grimmsʼ fairy tales, their semantic and structural features.
The research material. The titles of the most famous and popular fairy tales of German storytellers from the Kinder- und Hausmärchen collection.
In the research the general scientific and linguistic methods were applied: descriptive method, method of classification and systematization, elements of structural and semantic analysis and quantitative calculation.
The scope of application. The research can be used in the study and teaching of the style of the German language, pragmatics and text interpretation.
The results. The author names the structural features of the titles in Grimmsʼ fairy tales, gives a percentage of the number of title-words, title-phrases, title-sentences, lists their semantic features, focuses on complex words, talking names, numerals, appellatives, diminutive suffixes, as well as on the facts from the plot of the fairy tale that the reader can already learn from the title.
THE EFFECTS OF DIFFERENT COLLABORATION TYPES AND LEADERSHIP STYLES UPON GROUP PRODUCTIVITY
Authors: Markushev Ivan V. , Plotnikov Mikhail V. 
Published: December 2023

The paper studies how different collaboration types affect group productivity.
The study provides an experimental investigation of the effects the combinations of collaboration types (by L. Umansky, i.e. individual, consequent and interactive) and leadership styles (by K. Lewin, i.e. autocratic and democratic) upon the group productivity.
The experiment described simulates groupwork under different collaboration types and leadership styles. The six experimental stages allowed to register several objective and subjective productivity indicators. The analysis revealed the regularities between different combinations of the collaboration types and the leadership styles on one hand, and the productivity indicators on the other.
THE PROBLEM OF FINDING A METHODOLOGICAL BASIS FOR STUDYING THE HISTORY OF RUSSIA
Authors: Neronova Marina Yu. , Neronov Alexander V. 
Published: December 2023

The article formulates the problem of finding a methodological basis for understanding the history of Russia. Modern historical cognition needs close interaction with the philosophy of history, which is designed to give a logical form to the diverse material accumulated by historical science. Considering various philosophical approaches that have determined the understanding of the logic of historical development, the authors analyze the cognitive potential of each of them and outline ways to form a unified methodological basis for an adequate and comprehensive study of the history of our country.
Objective: to determine the role of the philosophy of history in historical knowledge and to identify conceptual approaches that can become the methodological basis for the formation of a new view of the history of Russia.
Method and methodology of the work: dialectical, historical and comparative research methods were used.
Results: During the analysis of the existing philosophical approaches, the most productive ones were identified, which can become the basis for forming a new methodological basis for studying the History of Russia.
Scope of the results: The results obtained can be applied in historical and philosophical research, as well as in the study of the history of Russia and the further development of the academic discipline “Fundamentals of Russian statehood”.
LINGUISTIC GLOBALIZATION PROCESSES IN THE CONTEXT OF THE MODERN SPANISH LANGUAGE POLICY
Authors: Shuliateva Eleonora V. 
Published: December 2023

The article examines the phenomenon of globalization and its impact on the language policy of Spain. The processes of neologization underlying the Spanish language policy are analyzed. It is shown how, in the conditions of the dominant role of the English language, the national languages of Spain resist external pressure in the form of Anglicisms.
Purpose. The purpose of the study is a theoretical and practical study of the influence of factors of linguistic globalization on the official languages of Spain.
Materials and methods. The texts of modern periodicals of Spain (El País, El Mundo, El ABC, LA Vanguardia) and the data of the explanatory dictionary of the Spanish Academy (Diccionario Real Academia Española) served as practical material for the study. To achieve the purpose of the study, the following methods were applied: analysis of scientific literature, continuous sampling method, method dictionary definitions, descriptive method.
Results. As a result of the study, it was revealed that Spanish national languages, influenced by the factors of linguistic globalization and the English language dominating in the international arena, are changing the familiar picture of the world in all spheres of life of modern Spanish society. The analysis of the data obtained showed that the Spanish language policy is not effective enough in the context of the current processes of linguistic globalization. Despite the active resistance to foreign-language borrowings and neologisms of foreign origin, Spanish language policy institutes do not have time to develop appropriate traditional equivalents.
Practical implications. The results of the study can be used in lecture courses on lexicology, lexicography, and linguistics, as well as in practical classes on the lexicology of the Spanish language.
Край света в центре Азии: Барнаул в романе Сергея Залыгина «После бури»
Authors: Kulyapin Alexander Ivanovich 
Published: December 2023

The city of Barnaul and the Ob River, on which it stands, appear in S. Zalygin’s last novel “After the Storm” (1982-1985) under two names at once: actually as “Barnaul” and “Ob”, but mainly as “Aul” and “River”. Replacing the real Barnaul with a fictional “Aul” is designed to emphasize the transition from geographical to metaphysical space. The novel takes place in an existential chronotope: the inhabitants of the city “Aul” live “on the border between being and not being.” Zalygin skillfully plays up facts from the real history of Barnaul, turning them into elements of a geopoetic myth. The peculiarity of the Zalyginsky “Aul” is that it is “Europe in Asia” and “Asia in Europe”. Here the twentieth century is adjacent to the Middle Ages. However, in 1917, rich in revolutionary upheavals, the fragile balance of power was disrupted. The hope for the feasibility of the Eurasian synthesis burned down in the fire of a catastrophic fire, which was caused in Barnaul-Aul by the chief city fire chief. It is noteworthy that “the only Horror Book in the world” is being created in the “Aul”. A city located on the “border of two worlds – the known and the unknown” turns out to be the most suitable place to store it.
The Relationship between Human and Artificial Intelligence in Victor Pelevin's Novels “S.N.U.F.F.”, “iPhuck 10”, “TRANSHUMANISM Inc.”
Authors: Altynbayeva Gul'nara Monerovna 
Published: December 2023

The article analyzes V.O. Pelevin’s view on the human and artificial intelligence interaction and highlights the risks of digitalization that the writer identifies. The article also attempts to answer two questions: what are the permissible limits of the influence machines and networks exert on human life and future and is there a way out of global dependence on artificial intelligence? Pelevin presents a satirical portrait of modern society; draws attention to the ways of salvation from total machine dependence; shows prospects and risks of the XXI century “new humanism”. The research has revealed five main similarities which identify Pelevin’s idea of the relationship between man and artificial intelligence. The theme is presented at the plot, problem-thematic and stylistic levels. Special attention is paid to Pelevin’s moral and philosophical reflections. The research is based on three Pelevin’s novels: “S.N.U.F.F.”, “iPhuck 10”, “TRANSHUMANISM Inc.”.
Taurodontic teeth in cone beam computed tomography: pictorial review
Authors: Fourneau Eléonore , Olszewski Raphael 
Published: December 2023

Objective: Taurodontism is a developmental disorder with enlargement of the body of the tooth and lack of cervical constriction, which results in a large pulp chamber and small roots with the apical displacement of furcation. Taurodontism exists in deciduous, and definitive unilateral, and bilateral teeth. We found that taurodontism was also described in 67 syndromes. We proposed a review of the open access literature on taurodontism, a new clinical classification of taurodontic teeth with illustrations from free open access literature, and from our case serie of 15 patients.
Material and methods: We performed a systematic search for articles with free full text about taurodontism. The search was performed by one observer in PubMed database. We found 168 articles, and after application of inclusion/exclusion criteria we finally selected 136 articles for the review.
Results: we provided 34 figures of taurodontic teeth related to: 1) Unilateral mandibular first premolar, 2) Unilateral mandibular second premolar, 3) Bilateral mandibular first and second premolar, 4) Bilateral upper maxillary first premolars, 5) Bilateral mandibular second molars, 6) Bilateral upper maxillary second premolar and left first molar, 7) Bilateral upper maxillary third molars, 8) Bilateral upper maxillary first and second molars, 9) Bilateral upper maxillary first, second, and third molars, 10) Bilateral upper maxillary molars (third molars, second, and first left upper molars), and mandibular molars (first right, and left mandibular molars, right third molar), 11) Bilateral upper maxillary molars (first, second, third right, and left upper molars), and mandibular molars, 12) Unilateral first mandibular premolar with cleft, 13) Bilateral molars of the mandible and the upper maxilla (adolescent patient who received chemotherapy at the age of 3-years-old to treat retinoblastoma), 14) Unilateral first maxillary molar (Treacher-Collins syndrome).
Conclusions: We proposed a new clinical classification of taurodontic teeth based on hypo-, meso-, and hypertaurodontism, and on different types of deciduous, and definitive teeth (42 boxes). We were first to provide free reference images for: 1) upper maxillary second premolar hypertaurodontism, 2) mandibular second premolar mesotaurodontism, 3) upper maxillary third molar meso-and hypertaurodontism, 4) mandibular first molar hypotaurodontism, 5) mandibular third molar mesotaurodontism. We were also first to freely illustrate taurodontism related with chemotherapy, cleft palate patients, and Treacher-Collins syndrome.
Degradation of Congo Red Dye in Wastewater using Ozonation Method with H2O2 Catalyst
Authors: Wulansarie Ria , Rozaq Muhammad , Bismo Setijo , Rengga Wara Dyah Pita 
Published: December 2023

The development of the industrial sector in Indonesia has increased very rapidly, especially in the textile industry. The increasing number of industries has an impact on the amount of industrial waste. Congo red dye is one of the dyes that are often used in the textile industry. Industrial dye waste needs to be processed so as not to damage the environment because the substances contained are harmful to the environment. One way that can be used to neutralize dye waste is ozone. Ozone can be used in many fields such as oxidation of inorganic/organic compounds and disinfection (or control of pathogens). H2O2 catalyst is used to accelerate the ozonation process. In this research the variables used were ozonation time (0.15,30,45,60 minutes), pH conditions (5,7,9) and the concentration of H2O2(0,2.5,5,7.5,10) % mass. Based on the research, it was found that the longer the ozonation time, the higher the pH value, and the more H2O2 used, the better the ozonation process results, namely the lower the concentration of dyes, COD, and BOD5 contained in the wastewater.