bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approaches to Selection of Optimal Chemotherapy Regimens in Tuberculosis Patients with Concurrent Diabetes Mellitus
Authors: Komissarova O. G. , Abdullaev R. Yu. , Aleshina S. V. 
Published: December 2023

The objective: to develop approaches to selection of optimal chemotherapy regimens in tuberculosis patients with concurrent diabetes mellitus (DM), by studying complications of diabetes mellitus and adverse drug reactions to anti-tuberculosis drugs.Subjects and Methods. 235 adult pulmonary tuberculosis patients with concurrent diabetes were enrolled in the study. Of them, 123 were men (52.3%) and 112 were women (47.7%), and the age of the patients varied from 19 to 78 years old.Results. Complications of diabetes mellitus (DM) were reported in 190/235 (80.8%) patients. Encephalopathy occurred most often – in 147/190 (77.3%) patients, diabetic macroangiopathy developed less often - in 41 (21.6%), followed by diabetic retinopathy – in 20 (10.5%), diabetic nephropathy - in 11 (5.8%), ketoacidosis – in 4 (2.1%), and diabetic foot – in 4 (2.1%). Diabetic macroangiopathy was significantly more often observed in men (66.7%) versus women (31.7%); p<0.01, and diabetic nephropathy was more common in women (81.8%) than men (18.2%); p<0.01. As the age of patients and duration of diabetes increased, the incidence of complications of diabetes also increased. Adverse drug reactions (ADRs) to anti-tuberculosis drugs (TB drugs) occurred in 168/235 (71.4%) patients. ADRs to two or more TB drugs were registered in 140/168 (83.3%) patients. The most frequent irreversible ADRs were caused by the following drugs (of the number of patients taking them): aminoglycosides (58.8%), capreomycin (54.5%), PAS (50.0%), ethambutol (100.0%), cycloserine (40.0%), levofloxacin (33.3%), pyrazinamide (23.3%), terizidone (28.6%), prothionamide (26.3%), linezolid (21.4% ), and moxifloxacin (20.0%).Conclusion. When treating pulmonary tuberculosis in patients with diabetes mellitus, chemotherapy regimens containing aminoglycosides, capreomycin, prothionamide, and pyrazinamide should be avoided. If there is even an initial stage of retinopathy, ethambutol should be avoided. Patients with encephalopathy should be switched from cycloserine to terizidone.
Specific Features of the Course and Treatment of Respiratory Tuberculosis in Women during Pregnancy and Postpartum Period. Perinatal Outcomes
Authors: Kayukova S. I. , Ulyumdzhieva V. A. , Idrisova L. S. , Karpina N. L. 
Published: December 2023

The objective: to study specific features of the respiratory tuberculosis course and effectiveness of its treatment during pregnancy and postpartum period, and to evaluate the impact of tuberculosis on perinatal outcomes.Subjects and Methods. In 2010 - 2022, a retrospective-prospective case-control study enrolling 164 patients of reproductive age was conducted in Central Tuberculosis Research Institute. Two groups were formed: Case Group included 82 pregnant women with respiratory tuberculosis; Control Group included 82 non-pregnant patients with respiratory tuberculosis.Results. In both groups, new cases of respiratory tuberculosis were notified more often versus relapses. Distinctive features of respiratory tuberculosis in pregnant women versus the non-pregnant were as follows: the predominance of the proportion of extensive drug resistant M. tuberculosis – 55.5% versus 31.7% (p<0.05), respectively; lower frequency of lung tissue destruction – 18.3% versus 32.9% (p≤0.05); higher incidence of cavities - 80% and 40.7% (p≤0.05) and complications of respiratory tuberculosis – 25.6% versus 12.2% (p≤0.03), respectively. The high effectiveness of respiratory tuberculosis treatment such as relief of clinical symptoms and sputum conversion was achieved at the end of the intensive therapy phase both in Case Group and Control Group. Longer time until sputum conversion and lower rate of cavity healing were reported in the patients from Case Group. In 75.6% of pregnant women from Case Group there was a delivery with favorable perinatal outcomes.
Non-Injection Chemotherapy Regimens for Drug Resistant Tuberculosis in Children and Adolescents
Authors: Aksenova V. A. , Klevno N. I. , Kazakov A. V. , Pakhlavonova A. D. , Romanenko V. A. , Nikolenko N. Yu. 
Published: December 2023

The objective: to determine the effectiveness and safety (tolerability) of non-injection chemotherapy regimens containing bedaquiline in pediatric patients with multiple drug resistant respiratory tuberculosis.Subjects and Methods. Effectiveness and safety of treatment regimens containing non-injection drugs and Bdq were studied in 45 children from Main Group (MG) aged from 5 to 17 years old inclusive who were ill with multiple drug resistant tuberculosis. Control Group (CG) included patients of the same age with MDR TB who were treated with chemotherapy regimens containing injectable drugs (a retrospective study).Results. After 24 weeks (the period during which patients took bedaquiline), clinical effectiveness of chemotherapy regimens was achieved in all patients. By the end of week 24 of treatment, significant positive radiographic changes were noted in 84.4% of patients in MG and in 75.7% in CG (OR 1.741; 95% CI 0.658–4.611), healing of cavities was achieved in 42 (93.3%) and 66 (94.3%) patients, respectively (OR 0.848, 95% CI 0.181-3.982). No tuberculous mycobacteria were not detected in 100% of cases in both groups by month 6 of chemotherapy. The number of adverse reactions (AR) per patient averaged 1.25 and 1.26 in MG and CG. ARs occurred in patients receiving aminoglycosides in 41.4%: in MG – in 33.3%; 4/70 (5.7%) children from CG receiving injectable drugs developed adverse reactions requiring replacement of anti-tuberculosis drugs. No irreversible ARs were observed in MG.
Evaluation of Effectiveness of 9- and 6-Month Treatment Regimens in Patients with Multiple Drug Resistant or Rifampicin-Resistant Tuberculosis in the Republic of Belarus
Authors: Yatskevich N. V. , Gurevich G. L. , Skryagina E. M. , Gurbanova E. 
Published: December 2023

The objective: to evaluate the effectiveness of 39- and 24-week treatment regimens in patients with multiple drug resistant or rifampicin-resistant tuberculosis (MDR/RR-TB).Subjects and Methods. We evaluated the effectiveness of 39- and 24-week treatment regimens containing bedaquiline, levofloxacin, linezolid, clofazimine, and cycloserine or delamanid (modified short-course regimens - mSCR) and bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaLM), in cohorts of patients with MDR/RR-TB. Results. Of the 550 and 139 patients were included in the mSCR and SMARRTT Studies (BPaLM regimen) from December 2019 to October 2021 and from March 2022 to August 2022, 90.7% (487/537) and 94.2% (131/139) achieved a successful treatment outcome, respectively, 13 patients were excluded from the mSCR Study and continued treatment according to an individual regimen. Median (ME) and quartiles [Q1-Q3] of sputum culture conversion time in patients treated with mSCR and BPaLM made 30.0 (25.0-56.0) and 27.0 (25.0-29.8) days (p<0.01) respectively. The prognostic factor for an unfavorable outcome for the BPaLM and mSCR regimens was a positive sputum microscopy result before treatment (OR – 7.92, 95% CI 1.5 – 41.0, p = 0.014; OR – 1.97, 95% CI 1.1–3.5, p=0.02, respectively), and for the mSCR regime, the time of sputum culture conversion >90 days was an additional prognostic factor (OR – 3.35, 95% CI 1.2–9.5, p=0.03) .Conclusions. The effectiveness of the mSCR and BPaLM regimens in patients with MDR/RR-TB is high (90.7% and 94.2%, respectively). Patients with positive sputum microscopy and late sputum culture conversion have a lower chance of cure.
Analysis of Respiratory System Functional Parameters at Different Time Points after COVID-19
Authors: Savushkina O. I. , Muravieva E. S. , Avdeev S. N. , Kulagina I. Ts. , Malashenko M. M. , Zaytsev A. A. 
Published: December 2023

The objective: to define the type and evaluate the severity of respiratory functional disorders after COVID-19. \Subjects and Methods. A retrospective observational study was conducted. The following parameters were analyzed: demographic data, data from chest computed tomography during the acute period of the disease (CTmax), parameters of pulmonary function tests (PFT) – spirometry, body plethysmography and diffusion test. Those data were collected in 341 patients, 262 (76.8%) of them were men (median age – 48 (41.5–57) years, median durtaion of Period A (onset of COVID-19 before PFT) made 53 (28.5–111) days). Depending on duration of Period A, patients were divided into three groups: Group 1 – up to 90 days (n=221), Group 2 – 90-180 days (n=80), and Group 3 – more than 180 days (n=40). In patients of Groups 1, 2 and 3, in 68.3%, 47.5% and 32,5% of cases, respectively, disorders of diffusing lung capacity were recorded, which were associated to a greater extent with CTmax, and to a lesser extent with duration of Period A. The restrictive type of ventilation disorders was observed in 33.5% and 11% of cases in Groups 1 and 2, no restriction was detected in Group 3, airway obstruction was detected in 8%, 5%, 7.5% of cases in Groups 1, 2 and 3 respectively.Conclusion. Disorder of diffusing lung capacity was the most common functional disorder of the respiratory system after COVID-19, and therefore it is advisable to include a diffusion test along with spirometry to the examination plan of such patients.
Experience of Fixed-Dose Combinations of Anti-Tuberculosis Drugs for Preventive Treatment in Children
Authors: Baronova O. D. , Aksenova V. A. , Klevno N. I. , Smerdin S. V. 
Published: December 2023

The objective: to evaluate the effectiveness and safety of preventive treatment with fixed-dose combination of anti-tuberculosis drugs (FDCs) in children from groups at high risk of developing tuberculosis.Subjects and Methods. Effectiveness of preventive treatment was analyzed in 318 children from groups at high risk of developing tuberculosis. Also, we studied the possibility of successful completion of the full course of treatment using FDCs and preventive treatment regimens containing at least two single drugs. Inclusion criteria were as follows: the child at high risk of developing tuberculosis; no clinical and radiological signs of active tuberculosis; lack of information about the resistance to first-line drugs at the suspected source of infection; and negative HIV status. A group of children (172 people) underwent preventive treatment using FDCs, of them 126 patients received FDCs containing isoniazid 150 mg + pyrazinamide 500 mg + pyridoxine hydrochloride 15 mg, and 46 patients received FDCs containing isoniazid 150 mg + ethambutol 400 mg + pyridoxine hydrochloride 15 mg. The comparison group (CG) included 146 children who received preventive treatment with single drugs: 111 children received isoniazid and pyrazinamide, and 35 children received isoniazid and ethambutol.Results. When assessing the safety and effectiveness, no statistically significant differences were found when using FDCs and single-drug regimens. 91.9% of children receiving FDCs and 86.3% of children receiving single-drug regimens successfully completed the full course of treatment. When taking FDCs, there was a tendency to lower incidence of adverse events. With the FDC (isoniazid 150 mg + pyrazinamide 500 mg + pyridoxine hydrochloride 15 mg), the proportion of adverse events did not exceed 4.0%. There were no adverse events with the FDC (isoniazid 150 mg + ethambutol 400 mg + pyridoxine hydrochloride 15 mg).Conclusion. Preventive treatment of children with tuberculosis infection with FDC is a modern and effective technology.
Simulation of Conditions and Results of Implementation of Short-Course Treatment Regimes in Tuberculosis Patients
Authors: Burykhin V. S. , Vasilyeva I. A. , Sterlikov S. A. , Testov V. V. , Kudrina V. G. , Urushadze N. D. 
Published: December 2023

The objective: to study the conditions of implementation of short-course (4 and 9 months) treatment regimens in tuberculosis patients and simulate their impact on the frequency of early treatment interruption (ETI) by patients.Subjects and Methods. Data on the treatment duration from enrollment to chemotherapy interruption in 8,029 tuberculosis patients were studied. Data were obtained from the Federal Register of Tuberculosis Cases for 2020. Of these, 3,379 patients were treated with regimens for susceptible or suspected susceptible tuberculous mycobacteria excluding isoniazid resistant tuberculosis, and 4,650 patients received regimens for rifampicin-resistant tuberculous mycobacteria.Results. The median duration of treatment from onset to ETI was 124 (95% CI 120-128) days in 3,379 patients, 224 (95% CI 215-233) days in 4,650 patients, or 170 (95% CI 157-181) days if there was a history of treatment interruption. Simulation of ETI terms when short-course chemotherapy regimens were introduced has shown that we can expect a 2-fold decrease in the proportion of patients who interrupted chemotherapy among patients with preserved/suspected susceptibility of tuberculous mycobacteria, and 1.3-1.7-fold decrease among patients with confirmed/presumed drug resistance of tuberculous mycobacteria at least to rifampicin.
Systematic Literature Review : Trend Penelitian tentang Pemahaman Matematis di Indonesia
Authors: Neneng Pitaloka  , Septian Ari , Soeleman Muhamad 
Published: December 2023

Rendahnya kemampuan pemahaman matematis peserta didik di Indonesia, membuat para peneliti mengambil topik ini untuk dijadikan latar belakang penelitiannya guna mendapatkan solusi terbaik akan masalah tersebut. Pada penelitan ini, peneliti mengkaji penelitian sebelumnya dan terkini dari artikel yang sudah terbit dengan tujuan mengetahui trend penelitian tentang pemahaman matematis di Indonesia dari tahun 2019-2023. Metode yang digunakan adalah Systematic Literature Review (SLR) dengan menganalisis artikel-artikel yang sudah sesuai dengan kriteria. Sampel yang sudah sesuai kriteria pada penelitian ini adalah 50 artikel yang sudah terindeks jurnal SINTA (Science and Technology Index), terbit tahun 2019-2023 dengan kata kunci “pemahaman matematis”. Analisis data yang digunakan mengacu pada model Miles dan Huberman yaitu reduksi data, penyajian data, dan verifikasi/penarikan kesimpulan. Berdasarkan hasil temuan, frekuensi artikel tentang pemahaman matematis di Indonesia kian meningkat jumlahnya yang dimana jurnal yang paling banyak menerbitkan artikel tentang pemahaman matematis adalah jurnal JPMI – Jurnal Pembelajaran Matematika Inovatif. Setelah mengolah data, artikel dikelompokkan sesuai dengan trend penelitian kemudian ditemukan bahwa, 1) pada trend materi matematika, peneliti cenderung memilih materi Sistem Persamaan Linear Dua Variabel (SPLDV) & Bangun Datar Segiempat dalam penelitiannya, 2) pada trend jenjang pendidikan, peneliti cenderung memilih jenjang SMP sebagai sampel penelitian, 3) pada trend jenis penelitian, peneliti cenderung menggunakan jenis penelitian Eksperimen.
Analisis Kemampuan Representasi Matematis Ditinjau dari Gaya Kognitif
Authors: Gunawan Fezrilya , Septian Ari , Sugiarni Rani 
Published: December 2023

Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan kemampuan representasi matematis siswa ditinjau dari gaya kognitif pada materi lingkaran. Metode yang digunakan adalah deskriptif kualitatif, dimana data diperoleh dari tes GEFT dan tes kemampuan representasi matematis. Subjek dalam penelitian ini adalah siswa kelas VIII di salah satu SMP di Cianjur. Teknik analisis data dalam penelitian ini melalui 3 tahapan yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Berdasarkan hasil penelitian diperoleh kesimpulan yaitu: 1) Siswa dengan kategori field dependent yang memiliki kemampuan representasi matematis pada kategori sedang, mampu memenuhi semua indikator kemampuan representasi matematis yang digunakan dalam penelitian ini yaitu indikator visual, simbolik, dan verbal. Siswa field dependent yang memiliki kemampuan representasi matematis pada kategori kurang hanya mampu memenuhi indikator visual serta belum mampu memenuhi indikator simbolik dan verbal; 2) Siswa dengan kategori field independent yang memiliki kemampuan representasi matematis pada kategori tinggi, mampu memenuhi semua indikator yaitu indikator visual, simbolik, dan verbal. Meskipun terdapat kekeliruan dalam pengerjaannya, siswa field independent mampu menentukan langkah awal yang lebih tepat dibandingkan siswa field dependent. Siswa field independent yang memiliki kemampuan representasi matematis pada kategori kurang hanya mampu memenuhi indikator visual dan belum mampu memenuhi indikator simbolik dan verbal.
The Role of Corporate Governance in Moderating the Influence of Corporate Social Responsibility Disclosure, Investment Risk and Firm performance in Manufacturing Companies Listed on the Indonesian Stock Exchange 2018-2022
Authors: Rohmah Baety Nur , Setiawati Erma , Trisnawati Rina 
Published: December 2023

Purpose: This study aims to analyze the impact of Corporate Social Responsibility Disclosure (CSRD) and investment risk on firm performance with CEO integrity, ownership concentration, and independent board as moderating variables. CEO integrity, concentrated ownership, and an independent board of directors are hallmarks of Good Corporate Governance (GCG). Methodology: This study uses manufacturing companies listed on the Indonesia Stock Exchange during the period 2018-2022. The total sample for this study included 107 dates. Purposive sampling technique was used for the sampling method and SPSS 24 software was used for data processing in this study. Results: The results of in this research show that CSR disclosure does not have a significant impact on firm performance. Investment risk has a positive and significant impact on a company's performance. CEO integrity does not moderate the effect of his CSR disclosure on firm performance, but ownership concentration and independent board of directors moderate the effect of her CSR disclosure on firm performance. Although CEO and independent board integrity do not moderate the effect of investment risk on firm performance, ownership concentration does moderate the effect of investment risk on firm performance. Applications/Originality/Value: Even if an organization makes CSR disclosures, it does not directly impact its financial performance. Companies must understand and carefully manage investment risk to maintain and improve performance. Additionally, this study shows how ownership concentration and independent boards moderate the impact of CSR disclosure, it shows that highlighting the importance of corporate structure in optimizing corporate sustainability impact.
Universal Humanitarian Principles Of Minangkabau Proverbs: A Living Law Perspective
Authors: Rusman Rina , Daulay Zainul , Danil Elwi , Sofyan Syofirman 
Published: December 2023

Difference from other studies that discuss proverbs from the perspective of art and linguistic, this study focused on its’ relevance with universal humanitarian principles adopted in various international treaties of international humanitarian and human rights laws. This study was conducted because several important treaties are not yet ratified by Indonesia due to an assumption that there are certain principles are not align with the living law in Indonesia. Even, the State needs to invoke certain provisions from the treaties to persuade the protection of its citizens being abroad whom trapped in situations of armed conflict and other situations of violence. This study answers this following question: Do Minangkabau proverbs provide sufficient relevant values which are align with the universal humanitarian principles? This research used the living law perspective and legal normative method in finding the relevant proverbs. The research result shows that the universal humanitarian principles can be found in certain relevant proverbs. At least 40 Minangkabau proverbs are compatible with and cover the ten universal humanitarian principles discussed. It proves that, from the cultural view, Indonesia is ready to ratify the certain main international treaties.
Сок ирги: научные факты о пользе, особенности приготовления и употребления
Authors: Шелестун Анна  , Елисеева Татьяна  
Published: December 2023

Ягоды ирги, похожие по форме и цвету на голубику, за что их часто путают, еще не приобрели у нас такой популярности. И совершенно зря! Кроме того, что само растение менее требовательно к условиям почвы и высадки, морозостойкое и обладает более высокой урожайностью, его плоды содержат гораздо больше витаминов и полезных микроэлементов, чем те же ягоды голубики. Кстати, с точки зрения ботаники плод ирги является вовсе не ягодой, а фруктом. Ведь он относится к подсемейству яблоневых.
Зрелые плоды ирги имеют оригинальный сладковатый ореховый привкус (некоторые сорта даже миндальный). Поэтому их широко используют в кулинарии — едят в свежем виде, а также готовят из них разнообразные компоты, джемы, пастилу, повидла, кисели. Особенно ценится среди почитателей народной медицины целебный сок из ирги.
HTML версия статьи
Сок лимонника: полезные свойства и особенности употребления уникального напитка
Authors: Шелестун Анна  , Елисеева Татьяна  
Published: December 2023

Китайский лимонник, или шизандра, представляет собой своеобразную лиану, вырастающую длиной до 15 метров. Растение не имеет ничего общего с цитрусовыми, а получило свое название за характерный аромат, исходящий от его листьев. Оно часто используется в ландшафтном дизайне для эффектного оформления вертикальных поверхностей и считается одним из самых полезных для организма — занимает почетное второе место после женьшеня.
Лечебными свойствами обладают все части лимонника, от корней до семян, но наиболее популярными среди почитателей ЗОЖ и народной медицины считаются его плоды, называемые в народе ягодами пяти вкусов за оригинальный многогранный вкус. Из них готовят целебные настойки, чаи, а также отжимают вкусный и очень полезный фреш. Сок лимонника можно купить в специализированных торговых точках или приготовить самостоятельно из свежих ягод.
HTML версия статьи
Fabrication of a WO3-Bi2WO6 Composite Electrode by Electrodeposition and its Application for Microbial Degradation
Authors: Sangthong Chotika , Ponchio Chatchai 
Published: December 2023

Photoelectrocatalytic (PEC) techniques are an innovative and promising method for eliminating microorganisms. Developing and applying such advanced technologies is essential for protecting public health and the environment. Semiconductor electrode development is a major issue in the advancement of such methods. We have developed a technique for fabricating WO3-Bi2WO6 electrodes using cyclic voltammetry (CV), focusing on the efficiency of the reaction and investigating key aspects for its use in microbial degradation. The optimization of the CV method parameter and calcination temperature was conducted in order to enhance the characteristics of composite WO3-Bi2WO6 electrodes for the aqueous oxidation process. The properties of the fabricated composited WO3-Bi2WO6 electrode were analyzed by several techniques, including UV-visible spectrophotometry, scanning electron microscopy, X-ray diffraction, Energy Dispersive X-ray Spectroscopy, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy. The PEC water oxidation and total microorganism elimination efficiencies were investigated to validate the application of the developed composite WO3-Bi2WO6 electrode properties. The characteristics of the prepared composite WO3-Bi2WO6 electrodes are significantly influenced by the calcination temperature. We were able to satisfactorily verify the electrodes' properties in a reaction involving different calcining temperatures. At a calcining temperature of 450 °C, WO3-Bi2WO6 electrodes exhibited excellent PEC activity in water oxidation and electron transfer rate at the electrode surface. The composited WO3-Bi2WO6 electrode can effectively remove 96% of total microorganisms under the PEC process within 15 minutes. This study provides important background information for future work on composite semiconductor thin film preparations with potential applications in microbe eradication and environmental protection.