bluuebunny/crossref_metadata_2025_split huggingface dataset:
The side‐effects and efficacy of leflunomide in Japanese patients with rheumatoid arthritis
Authors: KANBE Katsuaki , INOUE Kazuhiko , CHIBA Junji , NOGUCHI Masahiko , HIGUCHI Yoriko , MURATA Minako 
Published: August 2005

AbstractAims:  To investigate the efficacy and safety of leflunomide, including the side‐effects, we assessed 84 rheumatoid arthritis (RA) patients who received leflunomide treatment.Methods:  We analyzed the C‐reactive protein (CRP), white blood cell count (WBC), KL‐6, and visual analogue scale (VAS) scores, modified Stanford Health Assessment Questionnaire (MHAQ) score, American Rheumatism Association score (ACR20 and ACR50) within a time course after treatment with leflunomide. We treated 84 RA patients, 12 male and 72 female from 28 to 81‐years‐old, with an average age of 63.5 years. The patients were divided into three groups: a group consisting of 38 patients who received 100 mg/day of leflunomide for 3 days followed by 20 mg/day thereafter; a second group of 11 patients who received a no‐loading dose of 10 mg/day; and a third group of 35 patients who received a no loading dose of 20 mg/day.Results:  The 50% decrease of CRP seen in 2 weeks was 52% of the total of 84 patients. The WBC score did not change significantly after the medication was given. The KL‐6 score did not change significantly, either. The VAS pain score improved 4 weeks later, and then further improved 8 weeks later. Therefore, RA patients using leflunomide obtained pain relief 4 weeks after commencing medication. The MHAQ score did not change significantly until 8 weeks after the patients started the medication. ACR20 was 62% and ACR50 was 38% at 8 weeks after treatment. The side‐effects of leflunomide observed in our patients were rash, respiratory infection, diarrhea, nausea, alopecia, muscle pain, headache, dizziness and general fatigue. Twenty‐three out of 84 patients experienced side‐effects (27%), and 48/84 (57%) experienced withdrawal. In our hospital, there were no patients who developed severe interstitial pneumonia (IP) or who died after taking leflunomide; however, the incidence of side‐effects of the 100 mg/day loading dose (42.1%) was 2.5 times higher than in the patients who received 20 mg/day (17.1%) of a no‐loading dose.Conclusion:  Because of this, it is possible that a 100 mg/day loading dose is a relatively high risk dose in terms of causing side‐effects, especially for severely ill RA patients with a high CRP level.
Open access harvesting of wildlife: the poaching pit and conservation of endangered species
Authors: Bulte Erwin H. 
Published: August 2005

AbstractWe extend the traditional G–S model of open access by defining a non‐concave harvesting function. We demonstrate the possible existence of multiple equilibria and perverse comparative statics and show that small changes in the underlying economic parameters may trigger large jumps in species' abundance. Finally, we briefly discuss implications for management.
Trade policy, biotechnology and grain self‐sufficiency in China
Authors: Felloni Fabrizio , Gilbert John , Wahl Thomas I. , Wandschneider Philip 
Published: August 2005

AbstractOver the past 20 years the growth of China's agricultural economy has been extraordinary. However, it seems unlikely that China will maintain self‐sufficiency in grains by 2005 without substantial intervention. We develop a CGE model to assess the options available to Chinese policy makers. We compare the welfare effects of import tariffs and domestic support, and explore the potential of biotechnology as a means to achieve self‐sufficiency through improvements in agricultural productivity. Our results indicate that the price interventions that would be required to maintain China's desired self‐sufficiency ratios are considerable, and are unlikely to be compatible with WTO accession. The productivity improvements required are also significant, and likely beyond the current potential of biotechnology.
Market structure and the demand for veterinary services in India
Authors: Ahuja Vinod , Umali‐Deininger Dina , de Haan Cees 
Published: August 2005

AbstractThe livestock sector is emerging as one of the fastest growing agricultural sub‐sectors in India and the expectations are that this growth could further accelerate due to growing incomes and the high income elasticity of demand for livestock products. Given the size and relatively equitable distribution of livestock in India, this presents an excellent opportunity for the country to boost rural incomes and accelerate the pace of poverty reduction. But, successful capitalisation of such opportunities requires a policy regime that facilitates growth in productivity at the farm level as well as in the processing sector. The productive potential of animals depends crucially on the quality of nutrition, genetic material and the animal health system, and on all these counts, India has a poor record. The public sector continues to be the primary provider of veterinary services, and the deteriorating fiscal situation of most state governments is making it extremely difficult to either expand the reach of these services or improve the quality of service delivery. Although, on efficiency grounds, there is good rationale for commercialised delivery of these services, serious concerns prevail in India about the equity implications of private sector delivery or full cost recovery within the government system.Evaluation of the desirability of user fees or private delivery of livestock services requires an understanding of the factors influencing the demand for these services. This paper examines the nature of demand for veterinary services in three states of India and presents first estimates of demand elasticities for veterinary services. The results indicate that price is not an important determinant of the decision to use these services. Also, practically no variation is found in price elasticities across income groups. These results suggest that the fears of sharp declines in the use of these services as a result of full cost recovery and/or private sector delivery are unfounded.
Estimating the benefits of farm animal welfare legislation using the contingent valuation method
Authors: Bennett Richard M. , Blaney Ralph J.P. 
Published: August 2005

AbstractThis paper presents the method and findings of a contingent valuation (CV) study that aimed to elicit United Kingdom citizens' willingness to pay to support legislation to phase out the use of battery cages for egg production in the European Union (EU). The method takes account of various biases associated with the CV technique, including ‘warm glow’, ‘part‐whole’ and sample response biases. Estimated mean willingness to pay to support the legislation is used to estimate the annual benefit of the legislation to UK citizens. This is compared with the estimated annual costs of the legislation over a 12‐year period, which allows for readjustment by the UK egg industry. The analysis shows that the estimated benefits of the legislation outweigh the costs. The study demonstrates that CV is a potentially useful technique for assessing the likely benefits associated with proposed legislation. However, estimates of CV studies must be treated with caution. It is important that they are derived from carefully designed surveys and that the willingness to pay estimation method allows for various biases.
Access to credit, plot size and cost inefficiency among smallholder tobacco cultivators in Malawi
Authors: Hazarika Gautam , Alwang Jeffrey 
Published: August 2005

AbstractUsing data from the Malawi Financial Markets and Household Food Security Survey, this paper examines the effect of access to credit from formal sources, and tobacco plot size, on cost inefficiency among Malawian smallholder tobacco cultivators. Farm‐specific cost inefficiency is estimated within the framework of stochastic frontier analysis. Access to credit is measured as the sum of household members' self‐reported credit limits at credit organisations, arguably a truer measure of an exogenous credit constraint than credit program participation or actual loan uptake. It is found that tobacco cultivation is significantly less cost inefficient per acre on larger plots. While access to credit by itself has no statistically discernible effect on cost inefficiency, it reduces the gain in cost efficiency from a larger plot size.
Technological change and risk management: an application to the economics of corn production
Authors: Kim Kwansoo , Chavas Jean‐Paul 
Published: August 2005

AbstractThe paper investigates the linkages between technological change and production risk, with an application to corn. The effects of technology on risk exposure are analyzed. We define technological progress to be risk‐increasing (risk‐decreasing) if it increases (decreases) the relative risk premium. The analysis is applied to panel data from Wisconsin research stations. Conditional moments (including mean, variance and skewness) of corn yield, grain moisture and corn profit are estimated for different sites. We investigate how the trade‐off between expected return and the risk premium varies over time and over space. The empirical results indicate that technological progress contributes to reducing the exposure to risk as well as downside risk in corn production, although this effect varies across sites. They also stress the role of the relative maturity of corn hybrids as a means of managing risk.
Energy substitutability in transition agriculture: estimates and implications for Hungary
Authors: Shankar Bhavani , Piesse Jenifer , Thirtle Colin 
Published: August 2005

AbstractSubsidised energy prices in pre‐transition Hungary had led to excessive energy intensity in the agricultural sector. Transition has resulted in steep input price increases. In this study, Allen and Morishima elasticities of substitution are estimated to study the effects of these price changes on energy use, chemical input use, capital formation and employment. Panel data methods, Generalised Method of Moments (GMM) and instrument exogeneity tests are used to specify and estimate technology and substitution elasticities. Results indicate that indirect price policy may be effective in controlling energy consumption. The sustained increases in energy and chemical input prices have worked together to restrict energy and chemical input use, and the substitutability between energy, capital and labour has prevented the capital shrinkage and agricultural unemployment situations from being worse. The Hungarian push towards lower energy intensity may be best pursued through sustained energy price increases rather than capital subsidies.
Technology and efficiency in a panel of Italian dairy farms: an SGM restricted cost function approach
Authors: Pierani Pierpaolo , Rizzi Pier Luigi 
Published: August 2005

AbstractThis article employs a short‐term specification of the symmetric generalised McFadden (SGM) cost function capable of accommodating quasi‐fixed factors and variable returns. Temporary equilibrium and scale economies are investigated while maintaining the consistency of the estimated model with microeconomic theory and approximation properties. It also makes use of a two‐step procedure to estimate first the technology parameters and then time‐varying efficiency at farm level. No distributional assumptions are required on efficiency as we consider a fixed effect model. A balanced panel of Italian dairy farms during the years from 1980 to 1992 serves as the case study. The results suggest a rigid productive structure during the pre‐ and post‐quota period. Moreover, Italian milk producers are found to exhibit considerable excess capacity and rather low input technical efficiency.
Estimating the benefits of plant breeding research: methodological issues and practical challenges
Authors: Morris M.L. , Heisey P.W. 
Published: August 2005

AbstractImpact assessment studies consistently show that the benefits generated by plant breeding are large, positive and widely distributed. Numerous case studies have concluded that investment in plant breeding research generates attractive rates of return compared to alternative investment opportunities, that welfare gains resulting from the adoption of modern varieties (MVs) reach both favoured and marginal environments, and that benefits are broadly shared by producers and consumers. But just how reliable are the results of studies that estimate the benefits of plant breeding research? This article reviews methods used to estimate the benefits of plant breeding research and discusses theoretical and empirical issues that often receive inadequate attention in applied impact assessment work. Our objective is not to question the validity of the theoretical frameworks commonly used to estimate the benefits of plant breeding research, but rather to examine problems that can arise when the widely accepted theoretical frameworks are used for empirical analysis. Most of these problems can be grouped into three basic categories: (1) problems associated with measuring adoption and diffusion of MVs, (2) problems associated with estimating benefits attributable to adoption of MVs, and (3) problems associated with assigning credit among the various plant breeding programmes that participated in developing the MVs.
The economic costs and benefits of a participatory project to conserve maize landraces on farms in Oaxaca, Mexico⋆
Authors: Smale M. , Bellon M.R. , Aguirre J.A. , Rosas I. Manuel , Mendoza J. , Solano A.M. , Martínez R. , Ramírez A. , Berthaud J. 
Published: August 2005

AbstractConventional methods were used to assess the benefits and costs of an unconventional project whose purpose was to test whether participatory crop improvement can encourage Mexican farmers to continue growing maize landraces by enhancing their current use value. Findings suggest that farmers as a group earned a high benefit‐cost ratio from participating, though from the perspective of the private investor the returns were low. The project also generated social benefits, but these would be difficult (and costly) to measure. There was a gender bias in both participation and benefits distributions, though there is some evidence of a welfare transfer to maize deficit households. Application of other valuation approaches will be necessary in order to assess both the private and social benefits of similar projects.
The distribution of benefits from public international germplasm banks: the case of beans in Latin America
Authors: Johnson N.L. , Pachico D. , Voysest O. 
Published: August 2005

AbstractThe unrestricted international flow of genetic resources from international genebank collections is the source of perhaps one of the greatest impacts of international agricultural research. This paper examines the distribution across countries in Latin America of benefits generated from bean genetic resources held by the International Center for Tropical Agriculture (CIAT). The genealogies of commercial bean cultivars released since 1976, containing materials from the collection, are analysed to calculate for each country the source of the genetic resources used. All countries in the region are shown to be heavily dependent on imported genetic resources for their commercial cultivars. From the available information on the economic impact of these improved bean varieties, the share of economic productivity benefits associated with imported germplasm by country of origin is calculated. The benefits received by each country from improved bean germplasm are compared with the contribution of that country's germplasm to other countries. Some of the patterns in the flow and use of genetic resources are analysed.
The economic costs of conserving genetic resources at the CGIAR centers⋆
Authors: Koo B. , Pardey P.G. , Wright B.D. 
Published: August 2005

AbstractThe 11 genebanks of the Consultative Group on International Agriculture (CGIAR) have grown considerably in size over the past few decades, currently holding about 666,000 accessions of germplasm. Conserving germplasm is a very long run, if not in perpetuity, proposition. The mismatch between the mainly annual funding support for this conservation effort and its very long‐term nature and intent is a serious concern. Using the results of five CGIAR genebank case studies (accounting for 87% of the total CGIAR genebank holdings), we estimate the size of an endowment or trust fund that would be required to assure a funding stream to conserve this genetic material for future generations. The annual cost (in year 2000 US$) of conserving and distributing the genetic material presently held in all 11 CGIAR genebanks is estimated to be 5.7 million US$ (mUS$), which could be maintained for all future generations by setting aside a fund of 149 mUS$ (invested at a real rate of interest of 4% per annum). This would be sufficient to underwrite the costs for the CGIAR's current conservation activities in perpetuity (estimated to be 61 mUS$), as well as the cost of maintaining the distribution activities (88 mUS$) that provide germplasm to breeders, scientists, farmers and others world wide.
Adoption of improved maize varieties in the hills of Nepal
Authors: Ransom J.K. , Paudyal K. , Adhikari K. 
Published: August 2005

AbstractMaize (Zea mays L.) is the most important cereal crop in the hills of Nepal, where the grain is used for human consumption and the stover for animal fodder. Maize farms are small, and population pressure necessitates the intensification of existing farming systems. Maize research directed at developing technologies for maize production began in Nepal in 1965. In 2000, a survey was carried out in two districts to determine the current level of adoption of improved maize production practices. In each of these districts, remote and accessible village development committees (VDCs) were surveyed. Questionnaires were administered to 54 randomly selected households in each VDC. A Tobit analysis was used to determine socio‐economic, physical and technology factors that influence the use of improved varieties by farmers. All households use composted farmyard manure, and in the more accessible areas, urea as part of their soil fertility management strategy. Use of improved varieties was less than 60% for all VDCs and only 15% in the most remote VDC. In three of the four VDCs, adoption of improved varieties primarily occurred during the past 5 years. Based on a Tobit analysis, Khet land area, ethnic group, years of fertiliser use, off‐farm income, and contact with extension significantly and positively affected adoption of improved varieties. Farmers in VDCs in central Nepal reported lack of seed to be the major constraint to the adoption of improved varieties, while lack of knowledge of new varieties was the major constraint for farmers in the western VDCs. The results from this survey suggest that the strategy for improving the adoption of new varieties will differ depending on infrastructure and the socio‐economic conditions of the farmers in a given area.
Welfare effects of maize technologies in marginal and high potential regions of Kenya
Authors: Karanja D.D. , Renkow M. , Crawford E.W. 
Published: August 2005

AbstractThis paper describes the findings of a study that used a multi‐market model to assess the potential impact of improved maize technologies on the welfare of various types of rural and urban households in Kenya. The modelling results indicate that technologies developed for high potential regions are likely to have more profound aggregate impacts on maize production and lead to greater reductions in import demand (if prices are controlled) or maize prices (if maize prices are flexible). Technology adoption in high potential regions is likely to have substantially greater positive impacts on aggregate real incomes, but inferior income distributional outcomes compared to technology adoption in marginal regions.
Is research on marginal lands catching up? The case of unfavourable wheat growing environments⋆
Authors: Lantican M.A. , Pingali P.L. , Rajaram S. 
Published: August 2005

AbstractIt is widely believed that the Green Revolution had very little effect in unfavourable or marginal environments. Many researchers have been concerned about the slow progress of technical change in marginal environments and the level of research resources allocated to these areas. This paper provides empirical evidence that there has been significant growth in wheat yield potential in marginal environments, especially during the post‐Green Revolution. International yield trial data, covering all major wheat growing environments from 1964 to 1999, were used in estimating the growth in wheat yield potential and changes in yield variability. The global database on wheat varietal adoption and yield gains based on estimated wheat yield growth rates were used to determine production increases due to wheat breeding research. Results show greater progress in shifting the wheat yield frontier in marginal areas, particularly in drought and high temperature environments. Furthermore, yield variability in marginal environments has notably declined, while it has increased slightly in favourable environments. While initial gains came from crossover of varieties from favourable environments, targeted breeding efforts have contributed significantly to more recent productivity growth in marginal environments. Increased production from marginal environments accounted for around 25% of the total wheat production increase in 1997. These findings show greater progress in wheat research and the huge potential of improving wheat productivity in unfavourable environments.
Farm productivity and efficiency in the CEE applicant countries: a synthesis of results
Authors: Gorton Matthew , Davidova Sophia 
Published: August 2005

AbstractThis article draws together results from farm efficiency studies in six Central and East European countries that are part of the EU enlargement process. The main questions addressed concern whether there is a clear superiority of one organisational type, namely, family farms, over corporate structures (production co‐operatives and various types of farming companies) and the nature of the relationship between size and farm efficiency. Results from empirical research show that there is no clear cut evidence of corporate farms being inherently less efficient for all farming activities than family farms. Where significant differences have been found in favour of family farms against the average corporate farm, the best corporate farms still tend to perform as well as the best family farms. As far as size in concerned, in countries in transition where small family farms are well established and managed continuously by the present farm household, they appear to be less inefficient compared to larger cohorts as against countries where small family farms are a relatively new phenomenon.
Land degradation, drought and food security in a less‐favoured area in the Ethiopian highlands: a bio‐economic model with market imperfections
Authors: Holden Stein , Shiferaw Bekele 
Published: August 2005

AbstractThis paper presents a bio‐economic model of Andit Tid, a severely degraded crop‐livestock farming system with high population density and good market access in the highlands of Ethiopia. Land degradation, population growth, stagnant technology, and drought threaten food security in the area. Drought or weather risk appears to have increased in recent years. The bio‐economic model is used to analyse the combined effects of land degradation, population growth, market imperfections and increased risk of drought on household production, welfare and food security. We find that the indirect effects of drought on household welfare through the impact on crop and livestock prices are larger than the direct production effects of drought. Provision and adoption of credit for fertiliser, although risky in itself, may lead to increased grain production and improved household welfare and food security. Provision of credit may have a negative effect on conservation incentives but this effect may be mitigated by linking a conservation requirement to the provision of credit for fertiliser.