bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porphyromonas gingivalisassociates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population
Authors: De Vries Charlotte , Cîrciumaru Alexandra , Mathsson-Alm Linda , Westerlind Helga , Dehara Marina , Kisten Yogan , Potempa Barbara , Potempa Jan , Hensvold Aase , Lundberg Karin 
Published: January 2025

ObjectiveThe antibody response againstPorphyromonas gingivalis(Pg) is elevated in rheumatoid arthritis (RA), especially in patients with anti-citrullinated protein antibodies (ACPA). Here, we investigated whether antibodies against thePgvirulence factor arginine gingipain (Rgp) are associated with the RA-risk phase and development of arthritis.MethodsAt-risk individuals were included in a prospective study (Risk-RA) based on a positive anti-cyclic citrullinated peptide 2 (CCP2) antibody test, and having musculoskeletal complaints but no signs of arthritis. Study participants were followed for ≥3 years (arthritis-free, n=165) or until arthritis onset (progressors, n=95). Anti-Rgp IgG was measured in Risk-RA (260 baseline and 247 follow-up samples) and healthy controls (n=126); anti-CCP2 IgG was measured in Risk-RA (254 baseline samples). Data were analysed in GraphPad Prism and R using log-transformed antibody levels.Results53% of Risk-RA and 26% of controls, p=0.003, were anti-Rgp IgG positive at baseline, with higher levels in Risk-RA compared with controls, p<0.0001. No changes in anti-Rgp IgG levels were observed during follow-up. The anti-Rgp IgG response at baseline did not associate with the development of arthritis; Cox-regression showed an HR of 0.95 (CI 0.80 to 1.13, p=0.6) for anti-Rgp IgG levels, and 0.82 (CI 0.55 to 1.23, p=0.3) for anti-Rgp IgG positivity.ConclusionsAntibodies against the oral bacteriumPgare elevated during the RA-risk phase, both in individuals progressing to arthritis and in individuals remaining arthritis-free. Hence,Pginfection can be linked to the presence of RA-specific autoimmunity, ACPA, and musculoskeletal symptoms, but not to further development of arthritis in this at-risk population.
Combining hybrid and opaque scintillator techniques in the search for double beta plus decays
Authors: Böhlers Manuel , Böser Sebastian , Eisenhuth Magdalena , Girard-Carillo Cloé , Curiel Kitzia M. Hernandez , Keßler Bastian , Mossel Kyra , Palušová Veronika , Schoppmann Stefan , Weber Alfons , Wurm Michael 
Published: January 2025

Abstract
Double beta plus decay is a rare nuclear disintegration process. Difficulties in its measurement arise from suppressed decay probabilities, experimentally challenging decay signatures and low natural abundances of suitable candidate nuclei. In this article, we propose a new detector concept to overcome these challenges. It is based on the first-time combination of hybrid and opaque scintillation detector technology paired with novel light read-out techniques. This approach is particularly suitable for detecting positrons (beta plus) signatures. We expect to discover two-neutrino double beta plus decay modes within 1 tonne-week exposure and are able to probe neutrinoless double beta plus decays at several orders of magnitude improved significance compared to current experimental limits.
Country-Level Loss Aversion and the Market Response to Earnings News
Authors: Neel Michael 
Published: January 2025

Synopsis The research problem This study examined whether country-level loss aversion influences how investors respond to earnings news. Specifically, I examined the stock price sensitivity to negative earnings news vis-à-vis positive earnings news. Motivation Investor expectations about the amount, timing, and uncertainty of future cash flows largely determine a firm’s stock price. An earnings announcement’s primary role is to update expectations, which in turn leads to an update in firms’ stock prices. Historically, researchers have assumed an efficient and unbiased valuation process. However, the last quarter century has seen advances in areas such as behavioral finance that raise the question of under which conditions these assumptions no longer hold. This study investigated the role of investor loss aversion in the market response to negative and positive earnings news. The test hypotheses The first hypothesis is that country-level loss aversion is positively associated with the market response to negative earnings news. Second, country-level loss aversion is negatively associated with the market response to positive earnings news. Third, these associations are moderated by a country’s degree of short-term orientation, restraint vs. indulgence, power distance, and rule of law. Target population The target population includes all available publicly traded companies. Adopted methodology I used OLS on a pooled sample of archival data. Analyses I examined 266,630 annual earnings announcements across 45 countries from 1988 to 2021. I identified country-level loss aversion with two recently developed measures and ascertained investors’ sensitivity to earnings news using earnings response coefficients (ERCs) at both the pooled and country level. ERCs highlight how short-window stock returns covary with earnings news. Findings The results indicated that investors are more sensitive to bad earnings news in more loss-averse countries. In contrast, investor sensitivity to good earnings news is generally unassociated with loss aversion. Further analysis indicated that a subsequent return drift to extreme bad news is present among low-loss-aversion countries but not high-loss-aversion countries, suggesting that loss-averse investors more fully incorporate bad earnings news into stock prices. In contrast, the return drift to extreme positive news is detectable regardless of the level of loss aversion. The influence of loss aversion is more pronounced in countries with a short-term orientation and in countries characterized as more restrained.
10. Managing Groundwater in the Engineering Design & Construction of Surface Works
Authors: Blower Tim 
Published: January 2025

Examples of problems caused by groundwater, and methods of groundwater control are discussed in other chapters of this book. This Chapter deals with how the risks associated with potential groundwater problems may be managed in practice, in certain engineering situations relating to surface works.
For surface works, the problems caused by groundwater can be overcome in a variety of ways. Dealing directly with the groundwater itself (‘groundwater control’) is often an efficient way of addressing the problem and is, in many cases, essential.
However, this is not always the case. For some structures, modifications to the permanent works can avoid the need for a groundwater control solution that involves groundwater pumping, monitoring or maintenance in perpetuity.
Some design guidance documents require designers to assume that groundwater is at ground level unless there is better information. In this case, the optimal solution may include investment in a more comprehensive investigation to obtain the necessary data to challenge this onerous assumption.
In considering the management of groundwater, it is also important to manage surface waters, as these can quickly become sources of groundwater, affecting the groundwater regime.
Combining Structured Exercise with Interrupting Sitting Elicits Superior Cardiovascular Benefits Than Either Strategy Alone
Authors: Chang Courtney R. , Sabag Angelo , Francois Monique E. 
Published: January 2025

Objective: This study aimed to determine whether interrupting prolonged sitting with brief bouts of light-intensity activity (ISIT), undertaking structured high-intensity interval training (HIIT), or the combination of both interventions would elicit greater cardiometabolic benefits. Methods: Seventeen healthy adults (22-50 years) were recruited to undertake three 2-week interventions in a random order: i) HIIT (6 HIIT sessions + <5000 steps following the session and on the next day), ii) ISIT (2.5 min light-intensity walking every hour for 12 h/day on weekdays), and iii) HIIT+ISIT. Participants underwent a 6-day lead-in phase prior to each condition (day 1-3: normal activity, day 4-6 sedentary: <5000 steps/day). Pre and post assessments included glycemic control (primary outcome 2-h postprandial glucose), endothelial function via flow-mediated dilation (FMD), cardiorespiratory fitness and body composition. Changes in primary and secondary outcomes were assessed via repeated measures ANOVA. Results: Eleven participants completed all conditions (8 Female, 33±5 years, 23±4 kg/m2, habitual activity 7,156±2,272 steps/day). FMD significantly improved following HIIT+ISIT when compared to ISIT (+1.04±1.20%, p=0.02), but there were no differences when ISIT was directly compared to HIIT. Cardiorespiratory fitness improved significantly following HIIT+ISIT when compared to ISIT (+1.88±2.03 mL/kg/min, p=0.01) but there were no differences when ISIT alone was compared to HIIT. There were no significant differences between groups for outcomes related to glucose control or body composition. Conclusion: HIIT+ISIT elicits greater improvements in cardiovascular outcomes when compared to ISIT but not HIIT. The benefits of structured exercise, such as HIIT, may go beyond those achieved by limiting sedentary behavior alone.
A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity
Authors: Buckenmeyer Michael J. , Brooks Elizabeth A. , Taylor Madison S. , Orenuga Ireolu K. , Yang Liping , Holewinski Ronald J. , Meyer Thomas J. , Galloux Melissa , Garmendia-Cedillos Marcial , Pohida Thomas J. , Andresson Thorkell , St. Croix Brad , Wolf Matthew T. 
Published: January 2025

Abstract
Three-dimensional (3D) in vitro cell culture models are invaluable tools for investigating the tumor microenvironment (TME). However, analyzing the impact of critical stromal elements, such as extracellular matrix (ECM), remains a challenge. Here, we developed a hydrogel-free self-assembly platform to establish ECM-rich 3D “MatriSpheres” to deconvolute cancer cell-ECM interactions. Mouse and human colorectal cancer (CRC) MatriSpheres actively incorporated microgram quantities of decellularized small intestine submucosa ECM, which proteomically-mimicked CRC tumor ECM compared to traditional formulations like Matrigel. Solubilized ECM, at sub-gelation concentrations, was organized by CRC cells into intercellular stroma-like regions within 5 days, displaying morphological similarity to CRC clinical pathology. MatriSpheres featured ECM-dependent transcriptional and cytokine profiles associated with malignancy, lipid metabolism, and immunoregulation. Model benchmarking with scRNA sequencing demonstrated that MatriSpheres enhanced correlation with in vivo tumor cells over traditional ECM-poor spheroids. This facile approach enables tumor-specific tissue morphogenesis, promoting cell-ECM communication to improve fidelity for disease modeling applications.
Movimentos de paisagem na poesia de Herberto Helder: desdobramentos
Authors: Damião Solange 
Published: January 2025

This article intends to present the landscape in Herberto Helder's poetry, based on the analysis of some of the author's poems. Thus, through the concept of landscape as the perception of a space, of which the process takes place in the dependence between subject, place and representation, each poem unfolds in different landscapes from the horizon through which it is perceived by the lyric subject. For the different images generated, contribute references to the aesthetics of the poet who, with the landscapes created, manages to manifest in a sharp way the intensity of being a body in motion in the world.
Content and Item Response Theory Analysis of ChatGPT-4-Generated Multiple-Choice Items
Authors: Young Roger , Courtney Emily , Kah Alexander , Wilkerson Mariah , Chen Yi-Hsin 
Published: January 2025

Background Multiple-choice item (MCI) assessments are burdensome for instructors to develop. Artificial intelligence (AI, e.g., ChatGPT) can streamline the process without sacrificing quality. The quality of AI-generated MCIs and human experts is comparable. However, whether the quality of AI-generated MCIs is equally good across various domain- and task-specific prompts remains to be determined. Therefore, we ask whether AI can generate high-quality MCIs to assess learning outcomes from a psychology textbook chapter reading. Objective In an exploratory study, we enlist Item Response Theory analysis and expert reviewers to assess MCIs generated by ChatGPT-4 from a psychology textbook chapter. Method We submitted a prompt and textbook chapter to ChatGPT-4 requesting 20 MCIs. One hundred ninety undergraduate participants read the chapter before responding to the MCIs. Expert reviewers assessed the MCIs for learning outcome alignment and quality. Results ChatGPT-4-generated MCIs were low in difficulty and high in discrimination. Expert reviewers found that nearly all items were logically sound, aligned with learning objectives, and met prevailing standards of MCI quality. Conclusion When carefully prompted, ChatGPT-4 can rapidly generate high-quality MCIs to test comprehension of a psychology textbook chapter. However, due to the uniformly low difficulty of the items, we recommend enlisting ChatGPT-4 to write MCIs for formative, but not summative, assessments.
Exploring the experiences of cardiovascular perfusionists during philanthropic cardiac surgery in low-income countries
Authors: Jakkaraddi Bhumika , Araujo Lorena , Weinberg Allison , Kaur Ramandeep , Collins Julie 
Published: January 2025

Background: Medical mission trips address the global burden of cardiac disease, particularly in Sub-Saharan Africa, where limited access to cardiac surgery exacerbates challenges faced by affected individuals. However, a lack of literature exists on the experiences of perfusionists involved in these missions, despite their crucial role in delivering cardiac surgery services. Therefore, the purpose of this descriptive study was to evaluate the experiences of cardiovascular perfusionists involved in philanthropic cardiac surgery in low-income countries. Methods: A descriptive survey research design was conducted among perfusionists who have participated in cardiac mission trips. The survey link was distributed in February 2024 via the Liv Perfusion LLC social media account. The survey included questions regarding years of experience, countries visited, adequacy of equipment and personnel, language and cultural barriers, and establishment of long-term care. Results: A total of 23 respondents completed the survey, 15 of which were included in the study. All of the survey takers were perfusionists with a mean clinical experience of 10.67 ± 7.96 years and 67% held a master’s degree. All of the survey respondents were either very satisfied or satisfied with their cardiac mission trip experience. Despite high satisfaction, 60% reported language differences, and 40% reported cultural barriers and legal restrictions as significant challenges in their delivery of care. Additionally, 67% reported having adequate medical equipment and 80% reported having adequate personnel during the mission trip. Conclusion: In summary, cardiovascular perfusionists reported high satisfaction with philanthropic cardiac missions but faced challenges such as language barriers, and cultural and legal constraints. Addressing these issues could improve mission effectiveness and patient care in low-income countries.
An in vitro study of contrast agent optimization for MR hysterosalpingography
Authors: Ding Jin , Ding Huanzhi , Wang Ximing 
Published: January 2025

Background Gadolinium-iodine mixed contrast agents can significantly improve the visualization of the fallopian tubes in magnetic resonance hysterosalpingography (MR-HSG). However, the mixing ratio of gadolinium-iodine contrast agents has not yet been standardized. Purpose To explore the optimal mixing ratio of gadolinium-iodine contrast agents suitable for MR-HSG. Material and Methods A total of 16 mixing ratios of gadolinium and saline mixtures (Gd-NS), gadolinium and iopromide mixtures (Gd-I370), and gadolinium and iodixanol mixtures (Gd-I320) were formulated for an in vitro study. These mixed contrast agents were scanned on 1.5 T and 3.0 T using T1 contrast enhancement sequences. For qualitative assessment, contrast agent imaging quality was graded on a subjective 3-point scale (good, moderate, and poor). For the quantitative evaluation, differences in the signal intensity (SI) of the three contrast agents, as well as the SI variations between 1.5 T and 3.0 T, were compared. Results Gd-I370 and Gd-I320 exhibited the highest SI and good image at a 1:300 ratio on 1.5 T and a 1:200 ratio on 3.0 T. The difference in the SI among the three contrast agents was not statistically significant at 1.5 T ( P > 0.05). At 3.0 T, the comparison between the SIs of Gd-I370 and Gd-I320 was not statistically significant ( P > 0.05). The SIs of contrast agents on 3.0 T were higher than those on 1.5 T ( P < 0.05). Conclusion A gadolinium-iodine contrast agent with a 1:300 mixing ratio may be more suitable for 1.5 T MR-HSG, while a 1:200 mixing ratio may be more suitable for 3.0 T MR-HSG. Additionally, the contrast agent SI is higher on 3.0 T than on 1.5 T.
Treatment of recurrent shoulder dislocation by arthroscopic subscapularis augmentation using the long head of the Biceps tendon
Authors: Wang Jun , Huang Danlei , Ye Zhiyang , Weng Weizong , Wang Guangze , Liu Haoyuan , Huang Jianming 
Published: January 2025

Background Recurrent anterior shoulder dislocation is a common shoulder problem, usually caused by a force from the front when the shoulder joint is abducted and externally rotated. In the present study, we investigated the effect of arthroscopic subscapularis augmentation using the long head of the biceps tendon on shoulder motion after restoring anterior stability of the joint in patients with 13.5–20% of scapular glenoid defects. Methods Fifty patients admitted to our department with recurrent anterior shoulder dislocation between April 2017 and July 2021 were retrospectively analyzed. The patients were divided into two groups (groups A and B, n = 25 each) with comparable age, sex, hand dominance, and articular glenoid bone loss. Patients in group A were treated with arthroscopic Bankart repair and subscapularis augmentation, whereas those in group B underwent arthroscopic long head of the biceps transposition and subscapularis augmentation. All patients in both groups were followed up for more than 1 year, with a mean follow-up period of 20.1 ± 0.7 months (range, 13–28 months). The primary outcomes were changes in the visual analog scale score, Rowe classification, and Constant–Murley shoulder outcome score. Results None of the patients in either group had experienced recurrent dislocation at 1-year follow-up. The visual analog scale scores decreased, and the Rowe and Constant–Murley scores improved significantly compared to the preoperative scores. Significant differences were observed in the forward flexion, abduction, and internal rotation angles of the shoulder joint in both groups at 1-year follow-up compared to baseline. The postoperative forward flexion ( P = 0.143), abduction ( P = 0.778), and internal rotation angles ( P = 0.609) did not differ significantly between the two groups. At 1-year follow-up, the loss of angles of external rotation at the side and external rotation at 90° abduction in group B exhibited significantly less angular loss than group A. Conclusion Arthroscopic subscapularis augmentation using the long head of the biceps transposition technique was effective at restoring anterior stability in patients with 13.5–20% scapular glenoid defects. It was more effective at restoring the external rotational function of the shoulder joint than arthroscopic Bankart repair and subscapularis augmentation.
Multivariate contaminated normal linear mixed models applied to Alzheimer’s disease study with censored and missing data
Authors: Lin Tsung-I , Wang Wan-Lun 
Published: January 2025

The article proposes a robust approach to jointly modeling multiple repeated clinical measures with intricate features. More specifically, we aim to expand the scope of the multivariate linear mixed model by using the multivariate contaminated normal distribution. The proposed model, called the multivariate contaminated normal linear mixed model with censored and missing responses (MCNLMM-CM), is designed to handle minor outliers effectively, while simultaneously accommodating censored measurements and intermittent missing responses. An expectation conditional maximization either algorithm is developed to estimate the parameters of the proposed model in situations involving missing at random responses. We also provide techniques for approximating the asymptotic standard errors of the parameters, recovering censored data, imputing missing values, and identifying outliers. A simulation study is conducted to evaluate the finite-sample properties of the parameter estimators and demonstrate the superior performance of the proposed model compared to existing models. The proposed methodology is inspired by and applied to data from the Alzheimer’s disease neuroimaging initiative cohort study, which involves longitudinal clinical measurements of patients with mild cognitive impairment.
Translinguistic apposition: Structure and function of a language choice practice in Kinyarwanda news articles
Authors: Gafaranga Joseph 
Published: January 2025

Introduction: This paper investigates the structure and function of translinguistic apposition in Kinyarwanda news articles. In the structure, a Kinyarwanda noun phrase and a French / English noun phrase are juxtaposed as if the second clarified the first. Two major issues are identified, namely the possibility of translinguisticc apposition as practical action and its implicativeness relative to preceding and subsequent choices. These issues are identified against the background of two important discourse organisational principles, namely the principle of progressivity and that of the preference for same language discourse. Methods: Data were collected in two media blogs in Rwanda, namely Igihe.com and Umuseke.com using the method of theoretical sampling. They were analysed, in the tradition of the Ethnomethodology of Written Discourse, using a conversation-analysis-inspired qualitative analysis. Results: Translinguistic apposition is found to be possible as practical action because, organised as a parenthetical, it is shielded off from the reach of the preference for same medium discourse. It is also found to serve as a discourse-based language management strategy. Its implicativeness derives from this function. Discussion: Implications for the study of bilingual language use and for the practice of lexical development at the macro level are discussed.