bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do we explain painful non‐traumatic knee conditions to adolescents? A multiple‐method study to develop credible explanations
Authors: Djurtoft C. , Bruun M. K. , Riel H. , Hoegh M. S. , Darlow B. , Rathleff M. S. 
Published: November 2023

AbstractBackgroundPerceived diagnostic uncertainty can leave adolescents confused about their condition and impede their ability to understand “what's wrong with me”. Our aim is to develop credible explanations about the condition for adolescents suffering from non‐traumatic knee pain.MethodsThis multiple‐method study integrated findings from two systematic literature searches of qualitative and quantitative studies, an Argumentative Delphi with international experts (n = 16) and think‐aloud interviews with adolescents (n = 16). Experts provided feedback with arguments on how to communicate credible explanations to meet adolescents' needs; we analysed feedback using thematic analysis. The explanations were tailored based on the adolescent end‐users' input.ResultsWe screened 3239 titles/abstracts and included 16 papers exploring diagnostic uncertainty from adolescents' and parents' perspectives. Five themes were generated: (1) understanding causes and contributors to the pain experience, (2) feeling stigmatized for having an invisible condition, (3) having a name for pain, (4) controllability of pain, and (5) worried about something being missed. The Argumentative Delphi identified the following themes: (1) multidimensional perspective, (2) tailored to adolescents, (3) validation and reassurance, and (4) careful wording. Merging findings from the systematic search and the Delphi developed three essential domains to address in credible explanations: “What is non‐traumatic knee pain and what does it mean?”, “What is causing my knee pain?” and “How do I manage my knee pain?”ConclusionsSix credible explanations for the six most common diagnoses of non‐traumatic knee pain were developed. We identified three domains to consider when tailoring credible explanations to adolescents experiencing non‐traumatic knee pain.SignificanceThis study provides credible explanations for the six most common diagnoses of non‐traumatic knee pain. Additionally, we identified three key domains that may need to be addressed to reduce diagnostic uncertainty in adolescents suffering from pain complaints. Based on our findings, we believe that clinicians will benefit from exploring adolescents' own perceptions of why they experience pain and perceived management strategies, as this information might capture important clinical information when managing these young individuals.
HFIP Mediated Synthesis of C4‐Aryl‐2‐quinolones through Serial Oxidation
Authors: Hoon Lee Seung , Kang Minseok , Min Chi Hyung 
Published: November 2023

AbstractA practical, efficient approach for the synthesis of C4‐arylated 2‐quinolones from propargylic chlorides and anilines has been developed. The synthesis process involves subsequent oxidations of the initial products, tetrahydroquinolines and quinolinium ions, eventually leading to desired quinolones. A mechanism for the transformation is proposed based on a meticulous examination of intermediates and comprehensive control experiments. With a thorough understanding of the reaction mechanism, the applicability of the reaction scope is expanded.
The heat is on: Predicting urban stream temperature responses to summer storms
Authors: Knapp Julia L. A. , Kelleher Christa 
Published: November 2023

AbstractShort‐term increases in stream temperature in response to storm events have frequently been observed in urban areas, highlighting the need for improved understanding of the factors influencing urban stream temperature. Urban land cover complexity and infrastructure designed for rapid water routing to the sewer system create a direct link between storm events and water release processes, influencing urban stream temperature responses. This study aims to identify predictors of diverse stream temperature response patterns to summer storms. We analysed 403 storm events from six urban and semi‐urban catchments along the US East Coast using dynamic time warping to identify archetype patterns of stream temperature responses. We further disentangled observed stream temperature increase patterns to reveal the drivers associated with ‘heat pulses’, which are characterized by a rapid but high‐magnitude temperature increase followed by a sharp temperature drop at the start of the hydrograph increase. Our results show that stream temperature patterns were event‐specific and linked to pre‐event conditions and rainfall–runoff characteristics, with the shape of the hydrograph and rainfall–runoff response identified as the most important determinators of the observed temperature response patterns. Ponded surface waters and storm drains, as well as cooler water from the shallow subsurface, were identified as potential sources contributing to temperature patterns. These findings have important implications for understanding urban hydrology and the contributions of different source zones in urban catchments. Specifically, our results suggest that stream temperature may serve as a cost‐effective tracer providing information about urban water sources and pathways, thus aiding in the understanding of complex urban hydrology.
Selective pyrophosphate detection via metal complexes
Authors: Zhang Xiao , Sun Wenwen , Wang Le , Xie Zeping , Liu Mengxia , Wang Junfeng 
Published: November 2023

AbstractPyrophosphate (PPi) anions are crucial in numerous biological and ecological processes involved in energy conversion, enzymatic reactions, and metabolic regulation along with adenosine. They are also significant biological markers for various processes related to diseases. Fluorescent PPi sensors would enable visual and/or biological detection in convenient settings. However, the current availability of commercial sensors has been limited to costly enzymes that are not compatible for imaging. Sensor development has also encountered challenges such as poor selectivity and stability and limited practical applications. In this review, we analyze the situation of PPi sensing via commercial kits and focus on sensors that use metal complexes. We address their designs, sensing mechanisms, selectivities, and detection limits. Finally, we discuss limitations and perspectives for PPi detection and imaging.
MRI Quantification of Left Atrial Circumferential Strain in Mitral Regurgitation: A Feasibility and Reproducibility Study
Authors: Sreedhar Siva P. , Gupta Aakash , Chitiboi Teodora , Pradella Maurice , Elbaz Mohammed S.M. 
Published: November 2023

BackgroundMRI‐derived left atrial (LA) longitudinal strain has been shown to be a marker for mitral regurgitation, but the utility of LA circumferential strain remains unclear.PurposeTo assess feasibility and reproducibility of LA circumferential strain, identify changes in mitral regurgitation patients compared to healthy volunteers, and determine strain's association with mitral regurgitation severity and cardiac function.Study TypeRetrospective.Population52 mitral regurgitation patients, 12 healthy volunteers.Field Strength/SequenceSteady‐state free precession cine and 2D phase contrast sequences at 1.5T.AssessmentPeak LA circumferential strain was computed in each of three short‐axis slices (superior, mid, and inferior) and longitudinal strain computed from long‐axis slices using MRI feature‐tracking software. Strain test–retest reproducibility was determined from two repeat studies in healthy volunteers.Statistical TestsLA circumferential strain test–retest reproducibility was assessed by intra‐class correlation coefficient (ICC). Strain was compared between cohorts using Student's t‐test or Mann–Whitney U. Mitral regurgitation severity association with strain and LV function was assessed using Spearman correlation and multivariable regression. Significance was defined as P < 0.05.ResultsLA circumferential strain assessment was feasible in all subjects with moderate reproducibility in the superior (ICC = 0.74), mid LA (ICC = 0.71), and inferior LA (ICC = 0.63). In mitral regurgitation patients, LA circumferential strain was significantly lower in the superior (11.86% [6.5%,19.2%] vs. 18.73% ± 6.7%) and mid LA slices (18.41% ± 9.5% vs. 28.7% ± 10.4%) compared to healthy volunteers. Mitral regurgitation severity significantly associated with mid LA circumferential strain (β = −0.03) and LAV significantly associated with superior LA circumferential strain (β = −2.09), both independent of LA longitudinal strain and CO.Data ConclusionLA circumferential strain assessment is feasible with moderate reproducibility. Compared to healthy volunteers, patients had significantly lower LA circumferential strain. Mitral regurgitation severity and LAV were significantly associated with LA circumferential strain independent of LA longitudinal strain.Evidence Level3Technical EfficacyStage 2
Modelling some rod set imperfections of a quadrupole mass filter
Authors: Bugrov Pavel V. , Sysoev Aleksey A. , Konenkov Nikolai V. 
Published: November 2023

AbstractThe problem of modeling the mass peak shape of a quadrupole mass filter (QMF) with round rods is considered. A number of factors leading to the degradation of the mass peak shape are studied, namely, displacement of the electrodes with respect to their original position, changes in the diameter of the electrodes, and asymmetry of the supply potentials. Decomposition of the rod set field on multipole fields allows to obtain an analytical representation of the ion motion equations. Simulations have shown that a parallel shift of one or two electrodes leads to a shift of the peak along the mass number axis and dips at the peak apex. Unbalance of supply voltages does not significantly distort the peak shape, but it shifts the peak along the mass axis and creates a jump of the quadrupole offset potential proportional to the relative unbalance of X and Y rods potentials.
Clinical and radiographic evaluation of the use of PRF, CGF, and autogenous bone in the treatment of periodontal intrabony defects: Treatment of periodontal defect by using autologous products
Authors: Alshujaa Basem , Talmac Ahmet Cemil , Altindal Dicle , Alsafadi Anas , Ertugrul Abdullah Seckin 
Published: November 2023

AbstractBackgroundThe purpose of this randomized clinical study was to clinically evaluate and compare the efficiencies of platelet‐rich fibrin (PRF), concentrated growth factor (CGF) and autogenous bone graft (ABG) in the treatment of intrabony pockets and to assess the alveolar bone gain (AB gain) radiographically (panoramic and CBCT images).MethodsEighty intrabony pockets were divided into four groups: ojnly open flap debridement (OFD), OFD+PRF, OFD+CGF and OFD+ABG; each group consisted of 20 defects. Plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and tooth mobility (TM) by using Periotest M device were evaluated. Radiographic images were also taken to evaluate the AB gain. PRF was produced using a protocol of 2,700 RPM for 12 min and the relative centrifugal force (RCF) was evaluated. CGF was prepared as follows: 2 min 2700 rpm, 4 min 2400 rpm, 4 min 2700 rpm, 3 min 3000 rpm.ResultsThe study results revealed a similar improvement in PI and GI values in all groups (p > 0.05). There was a statistically significant decrease in PD and CAL in favor of ABG group at day 180 in comparison with other groups (p = 0.001). There was also a statistically significant decrease in TM and alveolar bone height loss (ABHL), whereby the AB gain gradually increased among the groups with the best group being ABG, followed by CGF, PRF, and control groups, respectively (p = 0.001).ConclusionsThe study results support the treatment of periodontal intrabony pockets using OFD in combination with ABG, CGF, and PRF, as ABG showed the best results followed by CGF and PRF.
The efficiency of preventive restructuring procedures: Evidence from France
Authors: Teti Emanuele , Tron Alberto , Colantoni Federico , Celani Edoardo 
Published: November 2023

AbstractThis article critically evaluates the effectiveness of the European Union's recent Directive on restructuring and insolvency law, specifically within the context of France, aimed at facilitating the restructuring of financially distressed firms within the Eurozone. Specifically, through the Kaplan–Meyer estimator and the log‐rank test, this research rigorously examines whether preventive restructurings surpass standard bankruptcy procedures in efficiency. The dataset under analysis is distinctly tailored, focusing on companies undergoing both types of restructuring procedures within the French jurisdiction. The study reveals that companies successfully undergoing a preventive restructuring procedure showcase higher survival rates, albeit coupled with weaker financial performances when compared to their counterparts undergoing the traditional bankruptcy process. This outcome challenges the prevalent assumption linking early‐stage restructuring with uniformly elevated survival rates and improved financial performance. A noteworthy concern stems from this observed trend, suggesting that the existence of discrete preventive restructuring procedures might inadvertently prolong the operational lifespan of financially inviable firms. This underscores the necessity for policymakers to meticulously craft preventive restructuring procedures, prioritizing debtor protection while proactively addressing the moral hazard predicament.
Effects of dietary citrus pulp level on the growth and intestinal health of largemouth bass (Micropterus salmoides)
Authors: Long Wen , Luo Jiajie , Ou Hongdong , Jiang Wen , Zhou Hang , Liu Yongyin , Zhang Lu , Mi Haifeng , Deng Junming 
Published: November 2023

AbstractBACKGROUNDCitrus pulp (CP) is rich in pectin, and studies have shown that pectin possesses antioxidant, anti‐inflammatory, and gut microbiota‐regulating properties. However, the application of CP in aquafeed is limited. In this study, the effect of dietary inclusion of CP on the intestinal health of largemouth bass (Micropterus salmoides) was investigated. Juveniles of similar size (6.95 ± 0.07 g) were fed isonitrogenous and isoenergetic diets containing different levels of CP (0%, 3%, 6%, 9%, 12%, or 15%) for 58 days.RESULTSAs the level of CP in the feed for largemouth bass increased, the fish's growth performance and intestinal health initially improved and then declined. Adding low doses of CP (≤9%) to the feed had no significant impact on the growth performance of large‐mouth black bass, whereas high doses of CP (>9%) significantly reduced their growth performance. Adding 6%, 9%, or 12% of CP to that feed enhanced the expression of genes related to tight junctions, anti‐inflammatory activity, anti‐apoptotic activity, and antioxidant activity in the intestines of largemouth bass. It reduced intestinal inflammation and improved intestinal nutrient absorption, intestinal mucosal barrier function, and intestinal antioxidant capacity. Moreover, it improved the α‐diversity, structure, and function of the intestinal flora. The addition of 6% CP had the most beneficial effect on the intestinal health of largemouth bass. On the other hand, the addition of 15% CP had adverse effects on the intestinal antioxidant capacity and intestinal mucosal barrier function of largemouth bass.CONCLUSIONAdding 6–9% CP to the feed for largemouth bass can improve their intestinal health without having a significant impact on their growth performance. CP could serve as a novel prebiotic and immunostimulant ingredient in aquafeed. © 2023 Society of Chemical Industry.
The Palatal Island Flap for the Reconstruction of Oral and Oropharyngeal Defects
Authors: Taghizadeh Farshid , Slijepcevic Allison A. , Colcord Madison E. , Chodroff Jonathon , Wax Mark K. 
Published: November 2023

The palatal island rotation flap is a rarely used reconstructive technique. The tissue is robust and the morbidity is low. It can be used as a primary reconstructive technique in patients with limited oral cavity/pharynx lesions. Healing is uneventful. In radiated pateints healing is prolonged and should be avoided.We describe 14 patients where the flap was used to reconstruct local defects. Patients with no history of radiation all healed quickly and well. Those with a history of radiatiuon had prolonged pain and delayed healing. Laryngoscope, 134:2718–2720, 2024
Open‐source magnetic resonance imaging: Improving access, science, and education through global collaboration
Authors: Winter Lukas , Periquito João , Kolbitsch Christoph , Pellicer‐Guridi Ruben , Nunes Rita G. , Häuer Martin , Broche Lionel , O'Reilly Tom 
Published: November 2023

AbstractOpen‐source practices and resources in magnetic resonance imaging (MRI) have increased substantially in recent years. This trend started with software and data being published open‐source and, more recently, open‐source hardware designs have become increasingly available. These developments towards a culture of sharing and establishing nonexclusive global collaborations have already improved the reproducibility and reusability of code and designs, while providing a more inclusive approach, especially for low‐income settings. Community‐driven standardization and documentation efforts are further strengthening and expanding these milestones. The future of open‐source MRI is bright and we have just started to discover its full collaborative potential. In this review we will give an overview of open‐source software and open‐source hardware projects in human MRI research.
Engagement of nonprofit organizations' followers on Instagram
Authors: Elvira‐Lorilla Teresa , Garcia‐Rodriguez Inigo , Romero‐Merino M. Elena , Santamaria‐Mariscal Marcos 
Published: November 2023

AbstractThis study analyzes the variables associated with followers' reactions to the Instagram posts of nonprofit organizations (NPOs). We analyzed all the 980 posts published by 58 Spanish nongovernmental development organizations on their Instagram feeds for 5 weeks. The results show that follower engagement, in terms of likes and comments, is associated with organizational characteristics of the NPOs (government grants, internationalization, religiosity), their use of social media (experience on other social media platforms, Instagram activity), and the content of the posts (engagement hierarchy classification, visual content, originality of content, use of interactive tools). For NPOs, these results indicate the importance of being aware of their own characteristics and the need to promote other aspects that they can control (the use of social media and the content they incorporate in their posts) to achieve greater levels of engagement.
Roux‐en‐Y versus one‐anastomosis gastric bypass (RYSA study): weight loss, metabolic improvements, and nutrition at 1 year after surgery, a multicenter randomized controlled trial
Authors: Heinonen Sini , Saarinen Tuure , Meriläinen Sanna , Sammalkorpi Henna , Penttilä Anne K. , Koivikko Minna , Siira Pertti , Karppinen Jaro , Säiläkivi Ulla , Rosengård‐Bärlund Milla , Koivukangas Vesa , Pietiläinen Kirsi H. , Juuti Anne 
Published: November 2023

AbstractObjectiveAlthough it has been suggested that one‐anastomosis gastric bypass (OAGB) is metabolically superior to the “gold standard,” i.e., Roux‐en‐Y gastric bypass (RYGB), there is little robust evidence to prove it. Because this result may arise from the typically longer length of bypassed intestine in OAGB, here, the authors standardized the bypass length in RYGB and OAGB and compared weight loss and metabolic outcomes in a randomized controlled trial.MethodsThe authors randomized 121 bariatric patients to RYGB (n = 61) or OAGB (n = 60) in two Finnish University Hospitals and measured weight; body composition; metabolic features (insulin sensitivity, lipids, inflammation, nutrition); and comorbidities before and 6 and 12 months after the operation.ResultsTotal weight loss was similar in RYGB and OAGB at 6 months (mean: 21.2% [95% CI: 19.4–23.0] vs. 22.8% [95% CI: 21.5–24.1], p = 0.136) and 12 months (25.4% [95% CI: 23.4–27.5] vs. 26.1% [95% CI: 24.2–28.9], p = 0.635). Insulin sensitivity, lipids, and inflammation improved similarly between the groups (p > 0.05). Remission of type 2 diabetes and hypercholesterolemia was marked and similar (p > 0.05) but the use of antihypertensive medications was lower (p = 0.037) and hypertension tended to improve more (p = 0.053) with RYGB versus OAGB at 12 months. Higher rates of vitamin D‐25 deficiency (p < 0.05) and lower D‐25 levels were observed with OAGB versus RYGB throughout the follow‐up (p < 0.001). No differences in adverse effects were observed.ConclusionsRYGB and OAGB were comparable in weight loss, metabolic improvement, remission of diabetes and hypercholesterolemia, and nutrition at 1‐year follow‐up. Vitamin D‐25 deficiency was more prevalent with OAGB, whereas reduction in antihypertensive medications and hypertension was greater with RYGB. There is no need to change the current practices of RYGB in favor of OAGB.
Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study
Authors: Raverdy Violeta , Chatelain Estelle , Lasailly Guillaume , Caiazzo Robert , Vandel Jimmy , Verkindt Helene , Marciniak Camille , Legendre Benjamin , Bauvin Pierre , Oukhouya‐Daoud Naima , Baud Gregory , Chetboun Mikael , Vantyghem Marie‐Christine , Gnemmi Viviane , Leteurtre Emmanuelle , Staels Bart , Lefebvre Philippe , Mathurin Philippe , Marot Guillemette , Pattou Francois 
Published: November 2023

AbstractObjectiveSteatotic liver disease (SLD) is frequent in individuals with obesity. In this study, type 2 diabetes (T2D), sex, and menopausal status were combined to refine the stratification of obesity regarding the risk of advanced SLD and gain further insight into disease physiopathology.MethodsThis study enrolled 1446 participants with obesity from the ABOS cohort (NCT01129297), who underwent extensive phenotyping, including liver histology and transcriptome profiling. Hierarchical clustering was applied to classify participants. The prevalence of metabolic disorders associated with steatohepatitis (NASH) and liver fibrosis (F ≥ 2) was determined within each identified subgroup and aligned to clinical and biological characteristics.ResultsThe prevalence of NASH and F ≥ 2 was, respectively, 9.5% (N = 138/1446) and 11.7% (N = 159/1365) in the overall population, 20.3% (N = 107/726) and 21.1% (N = 106/502) in T2D patients, and 3.4% (N = 31/920) and 6.1% (N = 53/863) in non‐T2D patients. NASH and F ≥ 2 prevalence was 15.4% (33/215) and 15.5% (32/206) among premenopausal women with T2D vs. 29.5% (33/112) and 30.3% (N = 36/119) in postmenopausal women with T2D (p < 0.01); and 21.0% (21/100) / 27.0% (24/89) in men with T2D ≥ age 50 years and 17.9% (17/95) / 18.5% (17/92) in men with T2D < age 50 years (NS). The distinct contribution of menopause was confirmed by the interaction between sex and age with respect to NASH among T2D patients (p = 0.048). Finally, several NASH‐associated biological traits (lower platelet count; higher serum uric acid; gamma‐glutamyl transferase; aspartate aminotransferase) and liver expressed genes AKR1B10 and CCL20 were significantly associated with menopause in women with T2D but not with age in men with T2D.ConclusionsThis study unveiled a remarkably high prevalence of advanced SLD after menopause in women with T2D, associated with a dysfunctional biological liver profile.