bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spillovers From Medicaid Contraceptive Use to Non‐Medicaid Patients: Evidence From New York
Authors: Callison Kevin , Carlos Marisa , Willage Barton 
Published: February 2025

ABSTRACTThis study examines spillovers from a 2014 New York Medicaid policy change that increased reimbursement for immediate postpartum long‐acting reversible contraceptive (LARC) insertion. Using administrative data on hospital deliveries from 2011 through 2019, we analyze whether physicians who inserted immediate postpartum LARCs for Medicaid patients following the policy change were more likely to subsequently perform the procedure on non‐Medicaid patients. We find significant spillovers, as physicians who first perform an immediate postpartum Medicaid LARC insertion following the 2014 payment reform are 9.3 percentage points more likely to perform immediate postpartum non‐Medicaid LARC insertions; an association that increases with the physician's share of Medicaid deliveries. To distinguish between physician‐specific and hospital‐specific factors driving spillovers, we compare physicians within the same hospital‐year. Results indicate approximately half the spillover is due to physician‐specific factors and half to hospital‐specific factors. Our findings highlight how targeted reimbursement policies can have broader impacts beyond the intended population and demonstrate the influence of both individual physician behavior and institutional factors in shaping clinical practice patterns. Understanding these spillover dynamics is important for policymakers and healthcare providers aiming to promote effective and equitable contraceptive care across patient populations.
Endoscopic and rectal tube management of pediatric sigmoid volvulus: A case series
Authors: Khemka Sapna , Morris Micah , Watson Kevin 
Published: February 2025

AbstractThe process of the sigmoid colon twisting on its mesentery is known as sigmoid volvulus, a diagnosis rarely seen in the pediatric population. Volvulus can lead to blood flow obstruction of the colon and eventually perforation, necrosis, or sepsis. Predisposing factors include chronic constipation, chronic dysmotility, or Hirschsprung disease. This communication demonstrates three patients who presented to a tertiary pediatric care center with a diagnosis of sigmoid volvulus. All three patients underwent immediate endoscopic detorsion and rectal decompression tube placement. Two patients subsequently underwent surgical resection of redundant sigmoid colon. This communication highlights the use of sigmoidoscopy for detorsion of uncomplicated sigmoid volvulus with added support for initial rectal decompression tube placement, contributing to initial patient stabilization and positive patient outcomes.
Successful Psoriasis Management With Deucravacitinib After Guselkumab‐Associated Eosinophilic Pneumonia
Authors: Lovell Katie K. , Feldman Steven R. 
Published: February 2025

ABSTRACTEosinophilic pneumonia (EP) involves the accumulation of eosinophilic infiltrates in the lung parenchyma, potentially triggered by smoking, infections, or medications, including biologics for psoriasis. This case report describes a 49‐year‐old female with a history of psoriasis and chronic pancreatitis, who developed EP after initiating guselkumab, an IL‐23 inhibitor. Following a 4‐month hiatus from ustekinumab due to insurance issues, she received guselkumab for a psoriasis flare (60% BSA). Shortly before the second dose, she presented with pleuritic chest pain, cough, and shortness of breath. CT revealed extensive ground‐glass infiltrates, and bronchoscopy with bronchoalveolar lavage (BAL) showed 52% eosinophils, indicating EP. Two months postdischarge, follow‐up CT showed near‐complete resolution of opacities, and 4 months later, after tapering off of systemic corticosteroids, her psoriasis flared again (60% BSA). Due to EP and preference for a nonbiologic treatment, deucravacitinib, a TYK2 inhibitor, was initiated, resulting in well‐controlled psoriasis (BSA = 0%) after 3 months, with only mild, resolved acne. This case suggests deucravacitinib as a viable option for patients experiencing noninfectious pneumonia from prior biologic therapy and highlights the importance of monitoring for pulmonary symptoms in patients on biologics.
Cardiometabolic Impact of Encapsulated Cocoa Powder and Pure Cocoa Ingredients Supplementation: A Comparative Placebo‐Controlled RCT in Adults
Authors: Weigant Janina , Afchar Anuschka , Barzen Meike , Dicks Lisa , Zimmermann Benno F. , Schmid Matthias , Weinhold Leonie , Stoffel‐Wagner Birgit , Ellinger Jörg , Stehle Peter , Ellinger Sabine 
Published: February 2025

ABSTRACTConsuming cocoa rich in flavan‐3‐ols (particularly epicatechin [EC]) may reduce vascular stiffness and blood pressure (BP) and improve serum lipid profiles. Because interventional studies on pure EC exhibited inconclusive results, the role of other cocoa ingredients such as methylxanthines (MX) on vascular health was assumed. This study aimed to systematically compare the effects of flavanol‐rich cocoa and its major components EC and MX on vascular function and serum lipid levels. In a randomized controlled trial (RCT), 75 healthy young adults ingested capsules containing either (i) flavanol‐rich cocoa powder, (ii) EC, (iii) MX, (iv) EC + MX, or (v) placebo (n = 15 per group) daily for 4 weeks. Capsules provided equal amounts of EC and/or MX as the cocoa capsules. Pulse wave velocity (PWV), BP, endothelin‐1, and lipids were investigated before and after intervention. No group‐specific statistically significant differences in aortic PWV (p = 0.410) or any other parameters (p ≥ 0.05) were observed between before and after the intervention. Daily intake of neither flavanol‐rich cocoa nor pure cocoa ingredients influenced vascular function and lipid profiles in healthy adults. Consequently, RCTs involving subjects with increased cardiometabolic risk may clarify the effects of EC and MX as cocoa components on cardiovascular health parameters.Trial Registration: URL: https://drks.de/search/en/trial. Unique identifier: DRKS00022056
A novel multifrequency‐tuned transceiver array for human‐brain 31P‐MRSI at 7 T
Authors: Li Xin , Zhu Xiao‐Hong , Zhang Xiao‐Liang , Waks Matt , Chen Wei 
Published: February 2025

AbstractPurposePhosphorus‐31 (31P) MR spectroscopy imaging (MRSI) at 7 T is a powerful tool for investigating high‐energy phosphate metabolism in human brains with significantly improved signal‐to‐noise ratio (SNR) and spectral resolution. However, this imaging technique requires dual‐frequency radiofrequency coil for performing brain anatomical imaging and B0 shimming at proton (1H) operation frequency, and 31P MRSI at lower operation frequency. Herein, we introduce a novel 31P‐1H dual‐frequency radiofrequency coil design using a double‐tuned and double‐matched (DODO) coil that does not require complex circuitry or two coil layers and exhibits similar imaging performance as to single‐frequency control coils for both 31P and 1H imaging operations.MethodsWe constructed an eight‐element 31P‐1H dual‐frequency DODO transceiver array and compared its performance with a quadrature‐driven dual‐tuned eight‐element 31P and eight‐element 1H transverse electromagnetic volume coil for both phantom and in vivo human‐brain 31P‐MRSI studies at 7 T.ResultsThe DODO transceiver array achieved high spatiotemporal resolution 31P MRSI with 2.5‐cc nominal voxel size and 22‐min scan time covering the entire human brain, showing excellent SNR for mapping cerebral phosphorous metabolites such as phosphocreatine, adenosine triphosphate, and other low‐concentration metabolites. Compared with the transverse electromagnetic volume coil, the DODO array demonstrated large improvements in 31P‐MRSI SNR in both phantom and human brain studies, with over 5‐fold SNR gain in peripheral regions and over 2‐fold SNR gain in central brain regions.ConclusionThis simple and cost‐effective array design and excellent performance can greatly benefit human‐brain 31P‐MRSI applications at 7 T.
Mutism and rigidity due to antipsychotic‐induced catatonia improved by hemodialysis: A case report
Authors: Fujii Rintaro , Suga Ryota , Satoh Norihito , Watanabe Yasuo , Yoshimura Reiji 
Published: February 2025

AbstractBackgroundCatatonia is a psychomotor syndrome linked to various medical conditions. Among these, several reports have described antipsychotic‐induced catatonia (AIC). Treatment typically includes benzodiazepines and electroconvulsive therapy. Here, we report a rare case of AIC that showed an improvement in symptoms under hemodialysis.Case PresentationA 79‐year‐old man with diabetic nephropathy was admitted with acute renal failure and metabolic acidosis. Hemodialysis was initiated, and his acute renal failure and metabolic acidosis were mild. On Day 11, following an intramuscular injection of haloperidol (2.5 mg) for agitation the previous day, he developed mutism, rigidity, and resistance to mouth‐opening, leading to a diagnosis of AIC. His symptoms improved dramatically during the course of hemodialysis, with no recurrence after seven sessions. He was discharged after 49 days and did not experience recurrence of catatonia in the following 12 months.ConclusionWhile this case showed a rapid improvement in AIC following hemodialysis, no robust evidence implicating AIC and hemodialysis has been reported to date. This case suggests the potential role of hemodialysis in improving AIC symptoms. Further research to better understand the relationship between AIC and hemodialysis and the underlying mechanisms of catatonia is required.
Combining procedural and behavioral treatments for chronic low back pain: A pilot feasibility randomized controlled trial
Authors: Tanus Adrienne D. , Nishio Isuta , Williams Rhonda , Friedly Janna , Soares Bosco , Anderson Derek , Bambara Jennifer , Dawson Timothy , Hsu Amy , Kim Peggy Y. , Krashin Daniel , Del Piero Larissa , Korpak Anna , Timmons Andrew , Suri Pradeep 
Published: February 2025

AbstractBackgroundIndividual treatments for chronic low back pain (CLBP) have small magnitude effects. Combining different types of treatments may produce larger effects.ObjectiveTo (1) assess feasibility of conducting a factorial randomized controlled trial of these treatments; and (2) estimate individual and combined treatment effects of (a) lumbar radiofrequency ablation (LRFA) of the dorsal ramus medial branch nerves (vs. a simulated LRFA control procedure) and (b) Activity Tracker‐Informed Video‐Enabled Cognitive Behavioral Therapy program for CLBP (AcTIVE‐CBT) (vs. an educational control treatment) on back‐related disability at 3 months post‐randomization.MethodsParticipants (n = 13) were randomized in a 1:1:1:1 ratio in a 2 × 2 factorial randomized controlled trial. Feasibility goals included an enrollment proportion ≥ 30%, a randomization proportion ≥ 80%, and a ≥ 80% proportion of randomized participants completing the 3‐month Roland‐Morris Disability Questionnaire (RMDQ) primary outcome end point. An intent‐to‐treat analysis was used.ResultsThe enrollment proportion was 62%, the randomization proportion was 81%, and all randomized participants completed the primary outcome. Though not statistically significant, there was a beneficial, moderate‐magnitude effect of LRFA versus control on 3‐month RMDQ (−3.25 RMDQ points [95% confidence interval [CI], −10.18 to 3.67]). There was a significant, beneficial, large‐magnitude effect of AcTIVE‐CBT versus control (−6.29 [95% CI, −10.97 to −1.60]). Though not statistically significant, there was a beneficial, large effect of LRFA+AcTIVE‐CBT versus control (−8.37 [95% CI: −21.47, 4.74]).ConclusionWe conclude that it is feasible to conduct a randomized controlled trial combining procedural and behavioral treatments for CLBP.ClinicalTrials.gov Registration: https://clinicaltrials.gov/ct2/show/NCT03520387.
Discovery of novel skeletons of aphid repellents based on the key fragment of nepetalactone and plant volatiles
Authors: Lu Yiming , Li Zhong , Shao Xusheng , Maienfisch Peter 
Published: February 2025

AbstractBACKGROUNDAphids are significant agricultural pests, causing extensive crop damage and transmitting plant viruses. Conventional insecticide‐based pest control faces challenges such as human and environmental toxicity and resistance. As alternative solutions, pheromone‐based repellents have emerged as a promising approach. However, the instability of key compounds like (E)‐β‐Farnesene (EBF) has limited their effectiveness in field applications. To address these limitations, this study focuses on developing novel aphid repellent compounds based on plant volatiles and nepetalactone key fragments.RESULTSIn this study, a series of derivatives were designed and synthesized from the lead compound (±)I by incorporating plant volatiles, leading to the discovery of two novel compounds with new skeletons, IV‐13 and IV‐4. Through further modifications of the ring size and the alkyl substitutions, two optimized structures, compounds IV‐30 and IV‐36, were identified, demonstrating promising aphid repellent activities. Bioassays indicated that IV‐30 (RV = 85.2%) and IV‐36 (RV = 70.3%) exhibited significantly enhanced repellent properties compared to their precursor compounds. Molecular docking studies revealed strong binding interactions of these compounds with aphid odorant‐binding protein 3(OBP3), providing further evidence of their improved biological efficacy.CONCLUSIONThe introduction of novel structures such as compounds IV‐30 and IV‐36 based on nepetalactone and plant volatile fragments resulted in the discovery of novel promising para‐pheromones for aphid control. These compounds exhibit stable and effective repellent activities, providing a solid foundation for further development of synthetic aphid repellents in integrated pest management strategies. © 2025 Society of Chemical Industry.
Beyond the Country of Origin and the Receiving Society: Differentiated Place Attachments and Homes Among Dominican Immigrants in the Netherlands
Authors: Dinmohamed Sabrina 
Published: February 2025

ABSTRACTThis study moves beyond traditional questions regarding immigrants' integration into various domains of their receiving societies to explore the meanings of places and the associated feelings of home. By examining how specific geographical locations relate to these feelings, the study illuminates post‐migration experiences and realities that are often overlooked in studies of immigrants. Specifically, it explores the significance of both the country of origin and the receiving society in shaping immigrants' feeling of home. Two key findings emerge from this ethnographic research. First, the study underscores the diversity within immigrant communities regarding the perceived location of home, with a particular emphasis on the influence of stepwise migration trajectories on these perceptions. Second, the findings demonstrate that the feeling of home is rooted in a variety of factors. By examining this feeling, this study offers a valuable lens via which to understand immigrants' attachments to both their countries of origin and receiving societies, enriching our understanding of their settlement experiences.
Borrow Strength to Exert: Low‐Crystallinity Prussian Blue for Reduction Overload Enhanced Photothermal Therapy
Authors: Yao Yuxin , Yao Junlie , Xiong Shiyi , Sun Yabing , Lai Liangxue , He Chenglong , Jiang Shaohua , Elsayad Kareem , Peng Hao , Wu Aiguo , Yang Fang 
Published: February 2025

AbstractThe strategy “Borrow strength to exert” in Sun Tzu's Art of War refers to borrowing external forces to withstand the enemy. Inspired by this, applying this thought to cancer treatment can achieve a more efficient therapeutic effect. Therefore, a fulcrum to borrow the force is vital and significant. Compared with normal cells, tumor cells are more sensitive to redox stress owing to their abnormal redox metabolism. Herein, a regulatory protocol based on chloroauric acid (HAuCl4) is proposed to prepare small‐size and low‐crystallinity Prussian blue nanoparticles (LcPB NPs). Notably, LcPB NPs possess higher superoxide dismutase (SOD)‐like enzyme activity to induce reduction overload and destroy metabolic processes and organelle functions, which leverages the redox status defect in tumors as the fulcrum. Due to the down‐regulation of heat shock proteins (HSPs) mediated by redox imbalance, the inherent photothermal therapy (PTT) mode of LcPB NPs effectively inhibits tumor growth and disrupts calcium homeostasis. Additionally, LcPB NPs can improve the anticancer effect by inhibiting symbiotic bacteria. Meanwhile, their magnetic and optical response performance empowers magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) for tumor diagnosis. Therefore, this work executing the strategy “Borrowing strength to exert” by disturbing the redox balance represents a new antineoplastic paradigm.
Highly Specific and Sensitive SERS Detection of Putrescine Using Au Nanobowls@Cu‐MOF Embedded in a Hydrogel Nanoreactor
Authors: Cao Jiaying , Li Duoduo , Feng Shilun , Liu Xinling , Guo Xiaoyu , Wen Ying , Yang Haifeng 
Published: February 2025

AbstractPutrescine is of concern due to its toxicity and applications in monitoring food spoilage and water quality. However, it is difficult to realize highly selective and sensitive detection of putrescine with interferences from other biogenetic amines with similar molecular structures. In this work, Au nanobowls modified by Cu‐MOF (core‐shell Au bowl@Cu MOF) together with o‐phthalaldehyde (OPA) are embedded into sodium alginate hydrogel to construct a unique SERS substrate (OPA‐Au bowl@Cu MOF/hydrogel) for sensing of putrescine. In the confined space of porous hydrogel, the Schiff base reaction between OPA and putrescine resulted in the product of N, N‐dibenzylidene‐n‐butylenediamine (OPA‐Putrescine), which is easily captured by Cu‐MOF via copper‐nitrogen coordination and then detected thanks to the high SERS activity of Au nanobowls and the large Raman scattering cross‐section of OPA‐Putrescine. The above reaction contributed to a high selectivity to greatly suppress the interferences from many amino group‐containing molecules. The limit of detection (LOD) of gaseous and liquid putrescine is 1.2 × 10−9 and 6.3 × 10−10 mol L−1, respectively. Further, the application potential of this SERS‐sensor in food and environmental fields are demonstrated by the successful detection of putrescine in salmon and seawater samples.
A Bio‐Redox Dynamic Pickering Emulsion from Nature to Nature
Authors: Song Chenhao , Chen Zhiwu , Lian Xiaodong , Wang Yapei 
Published: February 2025

AbstractThe biosafety issue of Pickering emulsions has gradually become public. It is shown that the particles that make up Pickering emulsions, previously thought to be non‐physiologically toxic, may also pose a potential threat to human life and health, as well as to ecosystems, due to their inherent emulsifying capacity. Hence, the principle of “from nature to nature” is proposed, which refers to emulsifiers that are of natural origin and can be metabolized by natural biological processes to eliminate their emulsifying ability. A feasible pathway by which the natural small molecule, thioctic acid, is exploited for the preparation of Pickering emulsions is also presented. The strategy of calcium ion‐induced aggregation and ring‐opening polymerization of sodium thioctate is utilized for the preparation of particulate emulsifiers, thus forming stable O/W‐type Pickering emulsions. Benefiting from the antioxidant property of the thioctic acid moiety and the transdermal capacity of the emulsion itself, it combines protection of the bioactive substance with transdermal delivery. Furthermore, the particulate emulsifiers that are prepared, abundantly enriched with dynamic disulfide bonds, can be integrated into the natural metabolic pathway, specifically by being reduced through the involved glutathione, thereby facilitating their natural degradation and effectively mitigating any potential biological hazards.
Insights into Non‐Metallic Magnetic Resonance Imaging Contrast Agents: Advances and Perspectives
Authors: Wang Yanan , Ma Xuehua , Zhang Yunhao , Yang Yanqiang , Wang Pengyu , Chen Tianxiang , Gao Changyong , Dong Chen , Zheng Jianjun , Wu Aiguo 
Published: February 2025

AbstractTraditional metal‐based magnetic resonance imaging contrast agents (MRI CAs), such as gadolinium, iron, and manganese, have made significant advancements in diagnosing major diseases. However, their potential toxicity due to long‐term accumulation in the brain and bones raises safety concerns. In contrast, non‐metallic MRI CAs, which can produce a nuclear magnetic resonance effect, show great promise in MRI applications due to their adaptable structure and function, good biocompatibility, and excellent biodegradability. Nevertheless, the development of non‐metallic MRI CAs is slow due to the inherent low magnetic sensitivity of organic compounds, their rapid metabolism, and susceptibility to reduction. Designing effective multifunctional organic compounds for high‐sensitivity MRI remains a challenge. In this discussion, the mechanisms of various non‐metallic MRI CAs are explored and an overview of their current status, highlighting both their advantages and potential drawbacks, is provided. The key strategies for creating high‐performance MRI CAs are summarized and how different synthetic approaches affect the performance of non‐metallic MRI Cas is evaluated. Last, the challenges and future prospects for these promising non‐metallic MRI CAs are addressed.
MoCx/CoP Janus Structure Embedded Carbon Frame for Boosting Hydrazine Oxidation and Hydrogen Evolution Reactions
Authors: Li Wenjin , Liu Xuan , Li Xinzhe , Lin Huihui , Yan Shuguang , Lu Jiong , Chen Cheng , Lv Yi 
Published: February 2025

AbstractThe integration of hydrazine electrooxidation (HzOR) and hydrogen evolution reaction (HER) presents an efficient pathway for high‐purity hydrogen production. However, developing bifunctional catalysts remains challenging for the demands of multiple active‐centers and tailored electronic properties. Here, a unique Janus nano‐catalysts of MoCx/CoP embedded on carbon frameworks (MoCx/CoP@C) is introduced, featuring dual electronic states (depletion and accumulation)driven by charge redistribution within MoCx/CoP, acting as dual active‐sites (DAS) for both HER and HzOR. Theoretical analysis reveals these independent DAS in MoCx/CoP significantly enhance catalytic activity for both HER and HzOR. Specifically, accumulated electrons at MoCx/CoP interfaces weaken the bonding strength of N‐H in N2H4, thereby decreasing dehydrogenation energy barrier while electronic‐deficient Mo sites within MoCx accelerate H* desorption, thus promoting HER kinetics. This catalyst exhibits ultra‐low potential of −73 mV at 10 mA cm−2 for anodic HzOR, comparable to noble catalysts and low overpotential of 95 mV at 10 mA cm−2 for cathodic HER. When employed in an overall hydrazine splitting (OHzS) system, MoCx/CoP@C shows promising commercial potential, with low energy consumption (0.16 V), high Faradaic efficiency (95.4%) and long‐term stability. This study underscores the feasibility of designing independent DAS catalysts and elucidates the mechanistic origins of bifunctional activities.