bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexualized drug use among gay men and other men who have sex with men in Latin America: A description of the phenomenon based on the results of LAMIS-2018
Authors: Lisboa Cristian , Stuardo Valeria , Folch Cinta 
Published: October 2023

IntroductionSexualized drug use (SDU) to enhance and extend sexual relations may involve risks of substances abuse (intoxication, interactions and overdose) and higher exposure to HIV and other sexually transmitted infections. There are inconsistencies in the methodology and findings of previous research on SDU in Latin America (LA), and more studies are required. The purpose of this research was to characterize SDU in gay men and other men who have sex with men from 18 LA countries, and describe the aspects by comparing people who practice and do not practice SDU, at the general and country levels.Material and methodsCross-sectional study based on the data collected by LAMIS-2018. Dependent variable was SDU (last 12 months), and the independent variables were: drug use (in any context/in sexual context), sociodemographic, socioepidemiological, and psychosocial aspects. A descriptive analysis was carried out, comparing those who practiced and did not practice SDU.ResultsLAMIS-2018 included 64,655 participants, averaging 30 years of age. 13.6% declared having practiced SDU (6.6% with multiple partners). In the last sexual encounter the most commonly used drugs were cannabis (9.3%), poppers (6%), and Viagra (5.4%), and in the last encounter with multiple partners, poppers (19.7%), cannabis (17%), and Viagra (13.2%). HIV diagnosis was reported by 27% of people practicing SDU, vs. 14.3% in the other group. Severe anxiety-depression symptoms were more common among people practicing SDU (9.2% vs. 7%), as were the episodes of homophobic intimidation (52.6% vs. 48.2%), insults (34.4% vs. 28.6%), and aggression (4.1% vs. 3.0%).ConclusionsSDU was reported by a high percentage of people, with a predominance of the use of drugs related to sexual practice, and others for recreational use. Aspects described as the higher proportion of self-reported HIV diagnosis and severe symptoms of anxiety-depression among those who practiced SDU, show that is necessary to implement preventive strategies to reduce the harmful impacts that can sometimes result from this practice, including harm reduction policies, promote access to mental health services and support in situations of homophobia and stigma.
“I care about sex, I care about my health”: A mixed-methods pre-test of a HIV prevention mobile health app for Black women in the southern United States
Authors: Chandler Rasheeta , Guillaume Dominique , Francis Sherilyn , Xue Eric , Shah Kewal , Parker Andrea , Hernandez Natalie 
Published: October 2023

BackgroundBlack women experience higher rates of adverse sexual and reproductive health and HIV outcomes, however the use of mHealth to address these health disparities in this population has been inadequate. This study involved a one-month pre-test with Black women living in metro-Atlanta to evaluate the usability, acceptability, and engagement of an HIV prevention appSavvyHER.MethodsAn explanatory mixed-methods design was employed in which quantitative data was collected through weekly cross-sectional surveys, and qualitative data was collected through semi-structured in-depth interviews. Descriptive and ANOVA analysis was conducted for the quantitative data using STATA software. Qualitative data was analyzed through qualitative descriptive methods on Atlas.ti.ResultsParticipants had high levels of acceptability towards the app and usedSavvyHERmoderately. The most frequently used features were live groups (2.96 ±0.22, 95% CI 2.51,3.41), viewing resources and educational information (2.77 ± 0.21, 95% CI 2.33,3.20), and mental health monitoring (2.73 ±0.21, 95% CI 2.29,3.12). The least used features were pregnancy symptom monitoring (1.92 ±0.27, 95% CI 1.38,2.47) and STI symptom monitoring (2.0 ±0.25, 95% CI 1.48,2.52). In qualitative interviews, several women discussed how the ability to engage in active discussions and join live sessions with other end-users was a favorable aspect ofSavvyHER. Although the app’s primary focus was on sexual and reproductive health and HIV prevention, women were more likely to access mental health monitoring and physical activity monitoring features. Women expressed their fondness of the app design and interface as it was reflective of the diversity of Black women.ConclusionFurther research is needed to explore the efficacy in using SavvyHER and additional mHealth interventions to enhance Black women’s sexual and reproductive health and overall wellness.
Effect of Glucagon-Like Peptide-1 Receptor Agonists on Bowel Preparation for Colonoscopy
Authors: Yao Rebecca , Gala Khushboo S. , Ghusn Wissam , Abboud Donna M. , Wallace Franklyn K. , Vargas Eric J. 
Published: October 2023

INTRODUCTION:
Inadequate bowel preparation can result in decreased diagnostic accuracy and therapeutic safety of colonoscopy for colon cancer screening. The Boston Bowel Preparation Scale (BBPS) has been used to assess the quality of bowel preparation. Glucagon-like peptide-1 receptor agonists (GLP-1RA) are commonly used medications for diabetes mellitus and obesity that are known to delay gastrointestinal motility. We hypothesized that the use of GLP-1RA would be associated with decreased quality of bowel preparation.

METHODS:
We performed a retrospective cohort study of patients who underwent screening or surveillance colonoscopy at a large academic medical center between December 2021 and December 2022. We included patients taking any GLP-1RA for diabetes or obesity during colonoscopy defined as our cases, and patients who were prescribed GLP-1RA at one point but not within 3 months of colonoscopy defined as our controls. We excluded patients on any promotility or antimotility agents and those without BBPS recorded on their procedure report. Independent t test assessed statistical differences in the case and control groups to compare the quality of bowel preparation for continuous variables, and the χ2 test was used for categorical variables. Multivariate linear regression including diabetes as a covariate was also performed for continuous variables, and multivariate logistic regression was performed for categorical variables.

RESULTS:
A total of 446 patients were included in the study, comprising 265 (59%) cases and 181 controls (41%). There were no statistically significant differences between groups at baseline except for the diagnosis of diabetes (P = 0.001) with a higher proportion of patients with diabetes in the cases. The mean BBPS was significantly higher in controls (7.0 ± 1.9 vs 7.5 ± 2.4, P = 0.046) when controlling for diabetes. The percentage of patients with a total BBPS score of <5 was significantly higher in cases (15.5% vs 6.6%, P = 0.01). The proportion of patients who required a repeat colonoscopy due to poor bowel preparation was also significantly higher in cases (18.9% vs 11.1%, P = 0.041).

DISCUSSION:
The use of GLP-1RA was associated with a statistically significantly lower quality of bowel preparation, with additional clinical significance given a notable difference in the need for a repeat colonoscopy. It will be essential to understand the cumulative effect of medications that may delay gastric emptying on the quality of bowel preparation to better understand the appropriate measures and counseling that need to be taken before undergoing outpatient colonoscopies.
Utilization of Agro industrial Food Processing Wastes and Pollutants for Manufacture of Products of Industrial Value A review
Authors: Ray Swati , Mukherjee Avik , Ghosh Uma 
Published: October 2023

Rapid industrialization as a consequence of the population explosion has led to the expansion of the agricultureand food processing sector to feed every mouth and to meet rapidly growing market demand. Extensive harvesting and processing of crops and raw agricultural harvests, and production of secondary and tertiary wastes from industrial manufacturing operations associated with agricultural and food products have impacted the environment in adverse ways, which is causing irreparable damages. To minimize the carbon load on earth, several sustainable technologies have been developed, which can save the environment as well as generate some useful and industrially important products. This review work focuses on the current scenario of these wastes, and their harmful effects on nature in general, and on the environment in particular. It also suggests that sustainable techniques can minimize these harmful impacts, and can instead manufacture some valuable products like antibiotics, enzymes, organic acid, organic chemicals, biomass, pigment, flavors, solid fuel, and bioalcohol. Thus, this is a comprehensive and extensive account of the utilization of agricultural and food processing wastes to derive valuable, useful products.
Takotsubo Syndrome in Black Americans: Insights From the National Inpatient Sample
Authors: Vriz Olga , Mushtaq Ali Hassan , Elshaer Ahmed Nahid , Shaik Abdullah , Landi Irene , Alzahrani Talal 
Published: October 2023

Abstract

Background
Data on race-related differences in the clinical outcomes of Takotsubo syndrome are limited, particularly for Black patients. This study aimed to assess whether race and sex may have an additional impact on the inpatient mortality of patients with Takotsubo syndrome.

Methods
A total of 4,628 patients from the United States' National Inpatient Sample from 2012 to 2016 were identified; propensity score analysis revealed a similar propensity score between Black patients (n = 2,314) and White patients (n = 2,314), which was used to balance observed covariates. Sex and age distributions were identical between the 2 groups. The groups were also similar in baseline characteristics, including cardiovascular risk factors. White patients were compared with Black patients on in-hospital outcomes and inpatient mortality. A logistic regression analysis was conducted to measure the difference in mortality based on race and sex.

Results
Compared with White patients, Black patients had a higher percentage of in-hospital complications, including cerebrovascular accidents (4.9% vs 2.5%, P ≤ .01), acute kidney injury (25% vs 19%, P ≤ .01); longer lengths of stay (8 vs 7 days, P ≤ .01); and higher inpatient mortality (6.1% vs 4.5%, P < .01). When analysis was conducted with race and sex combined, inpatient mortality was higher among Black men than among White women (odds ratio, 2.7 [95% CI, 1.80-3.95]; P ≤ .01).

Conclusion
This study showed that Black patients with Takotsubo syndrome have higher in-hospital complications and inpatient mortality rates. When race and sex were combined, inpatient mortality was significantly higher among Black men than among either White men and women or Black women.
Designing superoleophobic and flame retardant coatings from fly ash based on layer-by-layer approach
Authors: Guo Junxiang , Wu Jianlong , Qinggele Jirigele , Zhao Zhixing , Wang Tongbin , Yang Hongjun , Cang Daqiang 
Published: October 2023

Abstract
The superoleophobic, superhydrophilic, and flame-retardant coatings were obtained through layer-by-layer (LBL) technology using fly ash (FA) as the core. Chitosan (CS), phytic acid (PA), and fluorosurfactant (FS50) were assembled onto FA by LBL assembly using the principle of electrostatic adsorption. The CS and PA were recycled assembled on FA core for 10 layers, which was further deposited with FS50 molecules as the final layer (marked as FA@CS-PA10@FS50). Multifunctional coatings consisted of the FA@CS-PA10@FS50 powders and polymer binders were formed and could be used on a variety of substrates of various shape and size. The obtained coatings presented superoleophobicity, superhydrophilicity, and flame retardance. The contact angles (CAs) of coated substrates were all greater than 150° towards various oils (rapeseed oil, diesel, hexadecane, and dodecane), while achieved water CAs as low as 0°. The as-fabricated coatings could efficiently separate different oil/water mixtures and lotions while avoiding pollution of the separated materials. The coatings also achieved superior flame retardance, and the fire was self-extinguished within 13 s. Moreover, it also obtained excellent mechanical durability.
A novel white mouse deer observation in Brunei Darussalam
Authors: Mannion Natasha L. M. , Charles Joseph K. , Gaulton Rachel , How Jerry Wong Sia , Khalid Salwa , Pfeifer Marion , Slik J. W. Ferry 
Published: October 2023

Abstract
Pure white animals have long been regarded as unusual and prized by hunters. For the first time, we report an incidence of a white lesser mouse deer (Tragulus kanchil), observed by camera trap in Brunei Darussalam. This adult individual was recorded on four separate occasions in the same location. Although the underlying cause of this rare phenotype is undeterminable from camera trap images, the individual does not display the pink eyes commonly characteristic of albinism. It is surprising that this individual has survived to adulthood, as its bright white colouration makes it more vulnerable to predation, as well as a target for hunters. Further study of this individual could reveal insights into how it has survived, and the genetic health of the local population of T. kanchil.
Prognostic evaluation of system immune-inflammatory index and prognostic nutritional index in double expressor diffuse large B-cell lymphoma
Authors: Su Fang , Lian Ke 
Published: October 2023

Abstract
Predicting MYC and BCL2 double-expressor lymphoma prognosis using the system immune-inflammatory index (SII) and prognostic nutritional index (PNI) (DEL). From January 2015 to December 2021, 281 diffuse large B-cell lymphoma (DLBCL) wax blocks were used to make tissue chips. Screening double expressor lymphoma (DEL) instances involved immunocytochemistry and fluorescence in situ hybridization. Academic analysis used clinicopathological characteristics and follow-up data. SII, PNI, and DEL prognosis were correlated using univariate and multivariate cox regression analysis. The median age of 78 DEL patients is 60 (range: 43–74). SII and PNI cut-off values of 603.5, 3.07, and 144 predict PFS and OS well. Lower SII is associated with longer PFS (HR for SII = 0.34, 95% CI 0.15–0.76, P = 0.006; HR for NLR = 0.46, 95% CI 0.22–0.99, P = 0.048; HR for PLR = 0.39, 95% CI 0.17–0.94, P = 0.025; LMR = 0.39, 95%, CI 0.17–0.94, P = 0.025) and OS (HR for SII = 0.16, 95% CI 0.05–0.51, P = 0.005; HR for PNI = 0.20, 95% CI 0.06–0.62, P = 0.002). SII and PNI are promising predictors for twofold expressor DLBCL. Combining these increase prediction accuracy.
A perception-induced /t/-to-/k/ sound change: evidence from a cross-linguistic study
Authors: Chu Man-ni , Gussenhoven Carlos , van Hout Roeland 
Published: October 2023

AbstractJohn Ohala claimed that the source of sound change may lie in misperceptions which can be replicated in the laboratory. We tested this claim for a historical change of /t/ to /k/ in the coda in the Southern Min dialect of Chaoshan. We conducted a forced-choice segment identification task with CVC syllables in which the final C varied across the segments [p t k ʔ] in addition to a number of further variables, including the V, which ranged across [i u a]. The results from three groups of participants whose native languages have the coda systems /p t k ʔ/ (Zhangquan), /p k ʔ/ (Chaoshan) and /p t k/ (Dutch) indicate that [t] is the least stably perceived segment overall. It is particularly disfavoured when it follows [a], where there is a bias towards [k]. We argue that this finding supports a perceptual account of the historically documented scenario whereby a change from /at/ to /ak/ preceded and triggered a more general merger of /t/ with /k/ in the coda of Chaoshan. While we grant that perceptual sound changes are not the only or even the most common type of sound change, the fact that the perception results are essentially the same across the three language groups lends credibility to Ohala’s perceptually motivated sound changes.
Hurdles and potentials when implementing internet-delivered Acceptance and commitment therapy for chronic pain: a retrospective appraisal using the Quality implementation framework
Authors: Bendelin Nina , Gerdle Björn , Andersson Gerhard 
Published: October 2023

Abstract

Objectives
Internet-delivered psychological interventions can be regarded as evidence-based practices and have been implemented in psychiatric and somatic care at primary and specialist levels. However, challenges as low adherence and poor routinization, have arisen during attempts to implement internet-delivered interventions in chronic pain settings. Internet-delivered Acceptance and Commitment Therapy (IACT) has been found to be helpful for chronic pain patients and might aid in developing pain rehabilitation services. However, the integration of IACT into standard health care has not yet been described from an implementation science perspective. The aim of this hybrid 1 effectiveness-implementation study was to evaluate the process of implementing IACT in a pain rehabilitation setting, to guide future implementation initiatives.

Methods
In this retrospective study we described actions taken during an implementation initiative, in which IACT was delivered as part of an interdisciplinary pain rehabilitation program (IPRP) at a specialist level clinic. All documents relevant to the study were reviewed and coded using the Quality Improvement Framework (QIF), focusing on adoption, appropriateness and sustainability.

Results
The QIF-analysis of implementation actions resulted in two categories: facilitators and challenges for implementation. Sustainability may be facilitated by sensitivity to the changing needs of a clinical setting and challenged by unfitting capacity building. Appropriateness might be challenged by an insufficient needs assessment and facilitated by aligning routines for communication with the clinic’s existing infrastructure. Adoption may be facilitated by staff key champions and an ability to adapt to occurring hurdles. Possible influential factors, hypotheses and key process challenges are presented in a logic model to guide future initiatives.

Conclusions
Sustainable implementation may depend on both the continuity of facilitating implementation actions and flexibility to the changing needs and interests of patients, caregivers and organization. We conclude that the use of theories, models and frameworks (TMF) as well as a logic model may ease design, planning and evaluation of an implementation process. Lastly, we suggest that IACT may be appropriate for IPRP when given before or after IPRP, focusing on psychiatric comorbidities.
Evaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhage
Authors: Aycan Abdurrahman , Tas Abdurrahim , Yeltekin Asli Cilingir , El-Tekreti Sama Amer Abbas , Arslan Ayse , Arslan Mustafa , Aycan Nur 
Published: October 2023

Abstract

Background
Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5–7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH patients. This study aimed to examine the possible relationships between these parameters and the occurrence of SAH and the clinical–radiological parameters in patients with acute SAH.

Methods
This study evaluated 44 patients, including 20 with SAH and 24 controls. We obtained blood from the patients and control groups, which was stored in heparinized tubes and used in determining tumor necrosis factor alpha (TNF-α), brain-derived neurotrophic factor (BDNF), acetylcholinesterase (AChE), caspase-3, and butyrylcholinesterase (BChE) enzymes.

Results
TNF-α, BDNF, AChE, and BChE enzyme levels were not related to the Glasgow Coma scale (GCS) score in the patient group (p > 0.05), whereas higher enzyme levels of caspase-3 were associated with lower GCS scores (p < 0.05). The difference between the control and patient groups in terms of mean TNF-α levels was statistically significant (p < 0.01). The BDNF levels were statistically insignificant in the patient groups (p > 0.05). Caspase-3, AChE, and BChE levels were significantly different between the control and patient groups (p < 0.01).

Conclusions
Our results may be valuable for predicting the prognosis, diagnosis, and follow-up of patients with SAH. However, further studies are required to elucidate the relationship between the clinical and radiological results in patients with SAH and certain enzymes, cytokines, and growth factors.
Effizienzsteigerung: Laufwegreduzierung durch Sprachsteuerung
Authors: Norda Marvin , Veenhuis Torben , Engel Christoph , Appell Jens-E. , Hahn Axel 
Published: October 2023

Abstract
Sprache ist die natürlichste Form der Kommunikation, dennoch ist die Industrie bei der Implementierung von Sprachsteuerung als Human Machine Interface (HMI) noch zurückhaltend. Dies liegt vor allem daran, dass Effizienzvorteile noch nicht praxisnah erforscht wurden. Dieser Beitrag stellt eine Methodik zur Abschätzung des Effizienzpotenzials von Sprachsteuerung durch die Reduzierung von Laufwegen vor. Diese wird anschließend anhand von zwei Fallstudien exemplarisch angewendet.
Maximal Fusion Capacity and Efficient Replenishment of the Dense Core Vesicle Pool in Hippocampal Neurons
Authors: Baginska Urszula , Moro Alessandro , Toonen Ruud F. , Verhage Matthijs 
Published: October 2023

Neuropeptides and neurotrophins, stored in dense core vesicles (DCVs), are together the largest currently known group of chemical signals in the brain. Exocytosis of DCVs requires high-frequency or patterned stimulation, but the determinants to reach maximal fusion capacity and for efficient replenishment of released DCVs are unknown. Here, we systematically studied fusion of DCV with single vesicle resolution on different stimulation patterns in mammalian CNS neurons. We show that tetanic stimulation trains of 50-Hz action potential (AP) bursts maximized DCV fusion, with significantly fewer fusion event during later bursts of the train. This difference was omitted by introduction of interburst intervals but did not increase total DCV fusion. Interburst intervals as short as 5 s were sufficient to restore the fusion capacity. Theta burst stimulation (TBS) triggered less DCV fusion than tetanic stimulation, but a similar fusion efficiency per AP. Prepulse stimulation did not alter this. However, low-frequency stimulation (4 Hz) intermitted with fast ripple stimulation (200 APs at 200 Hz) produced substantial DCV fusion, albeit not as much as tetanic stimulation. Finally, individual fusion events had longer durations with more intense stimulation. These data indicate that trains of 50-Hz AP stimulation patterns triggered DCV exocytosis most efficiently and more intense stimulation promotes longer DCV fusion pore openings.SIGNIFICANCE STATEMENTNeuropeptides and neurotrophins modulate multiple regulatory functions of human body like reproduction, food intake or mood. They are packed into dense core vesicles (DCVs) that undergo calcium and action potential (AP) fusion with the plasma membrane. In order to study the fusion of DCVsin vitro, techniques like perfusion with buffer containing high concentration of potassium or electric field stimulation are needed to trigger the exocytosis of DCVs. Here, we studied the relationship between DCVs fusion properties and different electric field stimulation patterns. We used six different stimulation patterns and showed that trains of 50-Hz action potential bursts triggered DCV exocytosis most efficiently and more intense stimulation promotes longer DCV fusion pore openings.