bluuebunny/crossref_metadata_2025_split huggingface dataset:
Male ductal carcinomain situ(DCIS) at a young age
Authors: Vastmans Emma , Han Sileny , Floris Giuseppe , Neven Patrick 
Published: February 2025

In this case, a man in his late 20s visited his general practitioner with unilateral left nipple discharge. Initially, he was treated with antibiotics and the nipple discharge stopped. When the discharge recurred after a few weeks, the patient was referred to the multidisciplinary breast centre in UZ Leuven. Clinical examination revealed an otherwise healthy but obese man (body mass index of 31 kg/m²). On examination, we were able to evacuate bloody discharge from a single duct by mild compression of the left nipple.The bilateral mammography and ultrasound showed an irregular retroareolar density of 40×50 mm with adjacent, multiple clustered microcalcifications over a total distance of 20 mm on the left side.The histopathological report after core needle biopsy revealed a poorly differentiated ductal carcinomain situ. Genetic testing for hereditary breast–ovarian cancer genes was negative. A simple left mastectomy with sentinel lymph node biopsy was performed. There was no indication for adjuvant chemotherapy or radiotherapy, nor for adjuvant endocrine therapy.
Clinical phenotyping of people living with type 1 diabetes according to their levels of diabetes-related distress: results from the SFDT1 cohort
Authors: Canha Dulce , Aguayo Gloria , Cosson Emmanuel , Vaduva Patricia , Renard Eric , Alzaid Fawaz , Bonnet Fabrice , Hadjadj Samy , Potier Louis , Vergès Bruno , Lablanche Sandrine , Benhamou Pierre Yves , Hanaire Helene , Reznik Yves , Riveline Jean-Pierre , Fagherazzi Guy 
Published: February 2025

IntroductionType 1 diabetes is burdensome, requiring complex daily management and making people more prone to emotional distress. To better detect diabetes-related distress (DD) and identify at-risk patients, we aimed to provide an in-depth characterization of DD in people with type 1 diabetes.Research design and methodsWe included adults with type 1 diabetes from theSuivi en France des personnes avec un Diabète de Type 1cohort who filled in the Problem Areas in Diabetes questionnaire (PAID ≥40 indicates high DD). Age and sex-adjusted multivariable logistic regression models analyzed individual characteristics, clinical indicators, diabetes-related complications and psychological factors. We further analyzed DD according to six data-driven subdimensions: emotional distress, fear of complications, social distress, eating distress, management distress, and diabetes burnout.ResultsIn total, 1220 participants (50.6% female, age 42 years (SD 13.9), diabetes duration 24.7 years (13.6)) had a total mean PAID score of 39.6 (21.7) and 592 (48.5%) reported high DD. Leading subdimensions of DD included fear of complications (50.1 (24.4)) and diabetes burnout (45.9 (24.5)). Females, younger age, social vulnerability, smoking, and the presence of retinopathy were positively associated with high DD (p<0.05). We observed similar DD levels across HbA1c levels and treatment modalities, including automated insulin delivery and continuous glucose monitoring use. Several psychological factors, such as anxiety/depression, poor sleep quality, and treatment burden, were strongly associated with DD (p<0.001).ConclusionsWe provide a holistic clinical phenotyping approach that enables the identification of determinants and prevalence of DD, overall and according to key DD subdimensions, in a large and diverse population. Our results underscore the importance of developing DD-targeted prevention and intervention strategies focused specifically on high-risk groups and the most impactful distress subdimensions to reduce the impact of type 1 diabetes burden.Trial registration numberNCT04657783.
Intravenous lidocaine for gut function recovery in colonic surgery: a health economic evaluation of the ALLEGRO randomised clinical trial
Authors: Atter Marek , Stoddart Andrew , Cotton Seonaidh , Vadiveloo Thenmalar , Innes Karen , Balfour Angie , Arnott Robert , Aucott Lorna , Batham Zoe , Foo Irwin , MacLennan Graeme , Nimmo Susan , Speake Doug , Norrie John , Paterson Hugh 
Published: February 2025

ObjectivesTo compare costs, health outcomes and cost-effectiveness of using intravenous lidocaine (bolus given at induction of anaesthesia, followed by infusion for 6–12 hours) during colorectal surgery to improve the return of gastrointestinal function.DesignWithin-trial planned analysis of data from a randomised controlled trial using an intention-to-treat approach.Setting27 hospitals from across the UK.Participants557 patients aged 25–91 having minimally invasive elective colorectal resection.InterventionA 1:1 randomisation between intravenous lidocaine and placebo, minimised for age (<50 years, 50–74 years, ≥75 years), gender, and trial centre.Primary outcome measuresMean differences between trial arms in 30-day and 90-day quality-adjusted life-years (QALYs) and 30-day total National Health Service costs, as well as the 30-day incremental cost-effectiveness ratio.ResultsCompliance and data quality were high. Intravenous lidocaine is associated with differences of £38 (95% CI: −£463, £589) in total 30-day costs, −0.0005 (95% CI: −0.0027, 0.0015) in 30-day QALYs and −0.0008 (95% CI: −0.0066, 0.0048) in 90-day QALYs. No large, statistically significant or meaningful differences in primary or secondary outcome measures between trial arms were detected, other than for the intervention costs.ConclusionIntravenous lidocaine is not found to impact costs or health outcomes for patients undergoing colorectal surgery. In the absence of a clinical effect, disinvestment from perioperative lidocaine could save costs associated with infusion monitoring.Trial registration numberInternational Standard Randomised Controlled Trial Number 52352431.
Measurement of K fluorescence analysis in ancient bone using X-ray transition edge sensor and semiconductor detectors
Authors: Li Zhi-Wei , Guo Si-Ming , Zhang Shuo , Wu Jin-Jie , Wang Zhen , Li Nan , Wang Zhong-Tao 
Published: February 2025

Abstract
Transition edge sensor (TES) have high energy resolution, which can extremely improve in various scientific experiments the energy spectrum analysis capability and have a wide range of applications in almost all fields covering the whole wave band of electromagnetic waves. The same Chinese ancient human bone sample was measured by fluorescence analysis using SDD, Si-PIN detector and TES detector. Typical representative results among the measurements of the three detectors were selected for comparative analyses. The experimental results showed that the TES detector has obvious advantages compared with the semiconductor detector, with a resolution of 21.2eV@3.69 keV, compared to 115.8 eV @ 3.69 keV and 143.9 eV @ 3.69 for SDD and Si-PIN detectors, respectively. TES detector even found some spectral lines that cannot be measured by semiconductor detectors, such as the 0.916 keV L line of Cu, L line of 2.86 keV Rh and so on. The experimental results demonstrate the TES detector’s outstanding performance in elemental spectral line detection. Compared to observations with semiconductor detectors, using X-ray TES enables clear resolution of spectral lines corresponding to elements present in the sample.
Solar-Triggered Engineered Fe Doped ZnS Nanoparticles for Environmental Remediation
Authors: Javaid Nisar , Ullah Asad , Rafiq Asma , Asghar Muzammal , Akbar Zubair , Naz Misbah , Samreen Ayesha , Riaz Saira , Naseem S 
Published: February 2025

Abstract
Modern society requires cutting-edge technologies built on renewable and sustainable energy sources to address the problems of environmental purification. In the present study, synthesis of pure and iron (Fe) doped zinc sulfide (ZnS) nanoparticles were carried out using co-precipitation technique. The prepared samples were characterized by x-ray diffraction (XRD) analysis, UV–visible spectroscopy, fourier transform infrared spectroscopy (FTIR), and photoluminescence spectroscopy (PL), to reveal the alterations in the structure and morphology of nanomaterials. XRD analysis showed the wurtzite phase of prepared nanoparticles. UV–visible spectroscopy reveals intensive absorption in the visible region upon Fe doping. The inclusion of Fe dopants into ZnS led to a decrease in the bandgap energy. FTIR spectra confirmed the presence of specific functional groups linked to the vibrational modes of samples. PL spectroscopy was used to study the transfer behavior of photo-generated electrons and holes in as prepared samples. The photoactivity and kinetics of photo-products were explored by monitoring photo-decolorization of methylene blue (MB) under solar irradiation. Photodecomposition of MB was dramatically increased when Fe-doped samples were employed relative to pristine ZnS. The present study suggests that Fe doped ZnS nanoparticles may be used as an efficient photocatalyst in wastewater treatment and associated environmental applications.
Phase 1 trial of selinexor in pediatric recurrent/refractory solid and CNS tumors (ADVL1414): A Children's Oncology Group Phase 1 Consortium Trial
Authors: Green Adam L. , Minard Charles G. , Liu Xiaowei , Safgren Stephanie L. , Pinkney Kerice , Harris Lauren , Link Gabrielle , DeSisto John , Voss Stephan , Nelson Marvin D. , Reid Joel M. , Fox Elizabeth , Weigel Brenda J. , Glade Bender Julia 
Published: February 2025

Abstract
Background: Selinexor is a first-in-class, central nervous system (CNS)-penetrant, oral inhibitor of exportin 1 (XPO1), the main nuclear exporter of many key tumor suppressors. We report a phase 1 trial of selinexor in children and adolescents with recurrent CNS and solid tumors (NCT02323880). Methods: A rolling-six design was used to evaluate the maximum tolerated dose (MTD) and first dose pharmacokinetics (PK) of selinexor administered once (QW, 35-45 mg/m2) or twice (BIW, 20-35 mg/m2) weekly during a 28-day cycle (Part A). Ten additional patients with high-grade glioma (HGG) were treated at the QW MTD (Part B). Results: In Part A, 49 patients were enrolled. Continuous BIW dosing was limited by extended hematologic toxicity. The MTD on a BIW schedule for three weeks on/one-week off (BIW 3/1) was 20 mg/m2/dose. Dose-limiting toxicities (DLTs) on this schedule included fatigue, acute reversible neurologic changes, neutropenia, thrombocytopenia, and AST/ALT increase. On a continuous QW schedule, the MTD was 35 mg/m2/dose, DLTs included seizure and thrombocytopenia. In Part B (HGG expansion), there were no additional DLTs observed. Non-dose-limiting toxicity included lymphopenia, leukopenia, neutropenia, thrombocytopenia, anorexia, fatigue, hypophosphatemia, nausea, and vomiting. There were no objective responses. The median number of cycles received was 1 (range 1-9); Eight of 59 patients (13.5%) received 5-9 cycles, five of whom had HGG. Conclusions: Selinexor-related toxicities were primarily hematologic and neurologic requiring dose or dose-frequency reduction. The MTD and recommended initial phase 2 dose of selinexor in children and adolescents with recurrent solid and CNS tumors is 35 mg/m2/dose QW.
Update on Retinoblastoma Predisposition and Surveillance Recommendations for Children
Authors: Kamihara Junne , Schienda Jaclyn , McGee Rose B. , Friedman Danielle Novetsky. , Rednam Surya P. , Brzezinski Jack J. , Kim Sun Young , Becktell Kerri D. , Lupo Philip J. , Gallie Brenda L. , Greer Mary-Louise C. , Hansford Jordan R. , Brodeur Garrett M. 
Published: February 2025

Abstract
Hereditary retinoblastoma is a classic cancer predisposition syndrome with risks beginning in early infancy. About 45% of children with retinoblastoma (RB) have hereditary disease. These children are at risk for both intraocular disease as well as additional neoplasms throughout their lifetime. Germline pathogenic variants (GPVs) in RB1 typically lead to bilateral intraocular disease, elevated risks of trilateral RB, and risks of subsequent malignant neoplasms (non-ocular tumors), especially sarcomas and melanomas. There is further increased risk of subsequent malignant neoplasms if radiation treatment is used. Herein, with a reconvening of the AACR Childhood Cancer Predisposition Workshop, we expand on strategies for identifying individuals with hereditary RB, with a focus on testing strategies for children with RB. We also provide updates from previous recommendations. Given the high penetrance of retinal tumors, we review the importance of close intraocular surveillance and consider recent data regarding surveillance for subsequent malignant neoplasms. Finally, we discuss the importance of counseling for survivors of intraocular disease to address risks of adult-onset tumors as well as to consider reproductive risks.
Understanding Sex Differences in Hypertrophic Cardiomyopathy Surgery: Insights From a Decade‐Long Cohort Study From China
Authors: Lu Tao , Zhu Changsheng , Nie Changrong , Meng Yanhai , Yang Qiulan , Lu Zhengyang , Song Yunhu , Wang Shuiyun 
Published: February 2025

Background
Sex differences in patients with hypertrophic cardiomyopathy have been elaborated by many studies. However, large studies of the association of patient sex with outcomes after surgical myectomy are scarce. This study evaluated sex disparities in a large Chinese cohort undergoing hypertrophic cardiomyopathy surgery.

Methods
The cohort encompassed 1613 patients, including 627 (38.9%) women who underwent septal myectomy between 2009 and 2018.

Results

At the time of surgery, women were 6 years older and had 1 year longer disease onset‐to‐surgery delay than men. They were more frequently in New York Heart Association class III/IV and had more severe left ventricular outflow tract obstruction. Compared with men, women had a notably higher left ventricular wall thickness index and a lower extent of late gadolinium enhancement. Women also had more mutations in
MYH7
and fewer in
MYBPC3
. Postoperatively, women had a higher operative mortality rate (1.3% versus 0.1%,
P
=0.006). The follow‐up results showed no significant difference between the sexes in all‐cause death (hazard ratio [HR], 0.67 [95% CI, 0.38–1.18];
P
=0.166). A U‐shaped association was observed between age and death in the overall population. However, women exhibited this association more obviously at age ≥55 years and men at <35 years. Moreover, women also had a higher risk of cardiovascular rehospitalization after surgery (HR, 1.40 [95% CI, 1.03–1.89];
P
=0.030).

Conclusions
In patients with obstructive hypertrophic cardiomyopathy, women had a similar fatal outcome but a worse nonfatal outcome than men after surgery. Measures improving quality of life may further enhance the event‐free survival of female patients. Close monitoring and follow‐up are warranted, especially in younger men and older women.
Multiple Shades from the Same Mirror
Authors: Atalay Gül Esra , Muratoğlu Pehlivan Bahar , Ribeiro Fábio 
Published: February 2025

Abstract
This study aims to analyze and compare the media coverage of femicide cases in Portugal and Türkiye, as well as the comments posted by social media users on femicide news stories, to understand the dynamics at play. Therefore, a sample from the Portuguese and Turkish media was collected, and a one-year analysis of the mainstream news sources was performed. The authors observed significant differences between the two countries. The Portuguese media tends to provide little coverage on femicide, not including victims’ age and marital status and only offering a brief description of the crimes. In contrast, Turkish media provide more thorough coverage by incorporating detailed information, including emotional descriptions, and engaging more in sensationalism. Facebook comments show that users from both countries reveal their real identities, while Turkish comments tend to exhibit greater aggression and more spelling mistakes.
The Influence of European States on the Establishment of Democratic Power in the Republic of Kazakhstan
Authors: Sarsenbayeva Zhanar , Aiekeshov Nurbolat , Amirov Arman 
Published: February 2025

Abstract
This study examines Europe’s democracy, rule of law, and human rights efforts in Kazakhstan. Historical, comparative, institutional, structural and functional analysis were used to investigate the issue. The study assesses Kazakhstan’s political system after independence, formulates Brussels-Astana cooperation areas within the EU Strategy for Central Asia, determines the state’s prospects for liberalization of the political regime, and describes democratic transit in the post-Soviet period. The constitutional reform of 2022, which sought to transform Kazakhstan’s state model, was also examined, as were the reasons why the EU has failed to promote democratic reforms in Central Asian republics since diplomatic relations were established. The study can be used in research and applied industries by researchers interested in democratization in the post-Soviet space and political processes in Central Asia.
The Pandemic’s Effect on Sino–Thai Relations and Chinese-Thai Businessmen
Authors: Chen Shangmao , Phattharathanasut Tuwanont , Lin Hsiaochen 
Published: February 2025

Abstract
This study examines Sino–Thai relationships in the context of the developmental state theory and the dependent developmental theory focusing on the pre- and post-pandemic eras of the Belt and Road Initiative, Thailand 4.0, and the Eastern Economic Corridor (eec). The study finds that prior to the outbreak of covid-19, Thailand chose to pursue both dependency theory and developmental state theory. However, after the pandemic, Thailand faced severe democratic erosion, and Bangkok decided to follow the path of dependency theory, ultimately relying heavily on Chinese assistance, leading to disappointment throughout the country. These issues have exacerbated anti-Chinese and anti-Chinese-Thai–conglomerate sentiments, as many believe that Thai government reliance on Chinese support was influenced by the lobbying efforts of Chinese-Thai businessmen. These sentiments have become a feature of student protests and the Milk Tea Alliance. This indicates that the close relationship between Thai elites and Beijing is not shared by many Thais, and suggests that the Thai government should reconsider its development strategy. Additionally, both Chinese and Chinese-Thai businessmen should be aware of the path chosen by the Thai government and its effects on their business interests.
Now or Never – One Year After the Closure of the Second Negotiation Round for the EU’s Accession to the echr: Will the Agreement Reached Suffice to Make Accession (Finally) a Reality?
Authors: Polakiewicz Jörg , Suominen-Picht Irene 
Published: February 2025

Abstract
This paper presents a comprehensive analysis of the negotiations and legal frameworks surrounding the European Union’s (EU) accession to the European Convention on Human Rights (echr), a process marked by complex legal and institutional challenges. Despite the formidable hurdles outlined by the Court of Justice of the European Union (cjeu) in Opinion 2/13, negotiators crafted the revised draft accession agreement (daa 2023), balancing the constitutional requisites of the EU with the echr’s integrity. The paper highlights how this achievement, endorsed by the Council of Europe’s Fourth Summit, not only promises to enhance human rights coherence in Europe but also aims to bridge potential legal divides. Key adjustments in the daa 2023 emphasise the negotiators’ commitment to maintaining the EU’s legal autonomy while ensuring its adherence to echr standards. The paper underscores the urgent need for finalising this ‘never-ending story,’ highlighting its critical role in fortifying human rights protection across Europe.
The Jebel Mokram Group Pottery: A Pan-Grave- or a Middle Nubian-Related Ceramic Tradition of Eastern Sudan?
Authors: Manzo Andrea 
Published: February 2025

Abstract
The Jebel Mokram Group of Eastern Sudan was defined in the early 1980s based mainly on its ceramic assemblage, other material culture and settlement patterns. The definition has been revised in recent years following renewed fieldwork and C14 dates, but the relationship between the Jebel Mokram Group and Nilotic Nubian cultures remains to be fully understood. This article reviews the relationship between the Jebel Mokram Group and the Pan-Grave horizon primarily based on a comparative analysis of their ceramic assemblages. It is proposed that the Jebel Mokram Group can be regarded as part of the Atbai Ceramic Tradition and a component of the Pan-Grave horizon, while also being a component of what is here called the Middle Nubian ‘super-horizon’. It is further suggested that the Jebel Mokram Group was a node in a socio-cultural network extending across Lower Nubia and Egypt and involving large sectors of the Eastern Desert.
Influence of Interannual Leaf Phenology Dynamics on Evapotranspiration Predictions
Authors: Ghaseminejad Ali , Bhat Nagaraj , Raghav Pushpendra , Kumar Mukesh 
Published: February 2025

Abstract
Evapotranspiration (ET) plays a crucial role in determining water and energy partitioning of precipitation between land and atmosphere. A recognized uncertainty in modeling of ET is a proper representation of leaf phenology dynamics. Many existing land surface models often employ a “static scheme” of leaf phenology while performing ET simulations, i.e., they assume identical intra-annual variation in leaf phenology, often quantified as the variation in leaf area index (LAI), from year to year. There is a need to assess the influence of this “static” scheme on ET prediction errors. Furthermore, it is important to determine where improvements in predictions of leaf phenology dynamic models will yield the largest improvements in ET predictions. Utilizing site-specific artificial neural network models for the estimation of ET, this study investigates the influence of static versus dynamic representation of leaf phenology dynamics on ET estimation errors across 30 flux network (FLUXNET) sites. Results indicate that neglecting the interannual LAI dynamics in the ET prediction model led to an additional loss of accuracy of up to 29% (0.18) with the average loss being about 1.7% (0.01) based on the percentage bias (coefficient of determination) metric. Our findings also show that interannual leaf phenology dynamics have a larger impact on ET estimates in warmer and drier regions. Phenological traits such as green-up onset anomaly and maximum annual LAI anomaly are identified as key contributors to model error in static phenology scenarios.
Geopsychiatry from below: Exploratory review and preliminary analysis
Authors: McGeachan Cheryl , Philo Chris 
Published: February 2025

Background: This contribution advances claims about ‘geopsychiatry from below’, attending to how ‘voices’ with lived experience of mental ill-health speak about ‘the geo’ or, more specifically, ‘place and space’. Aims: To explore relevant interdisciplinary literature for academic research, scholarship and commentary containing voices of experience speaking about the geo. Methods: An ‘indicative’ and ‘facilitative’ review of relevant transdisciplinary literature in arts and humanities and social science, alongside an exploratory workshop where materials are analysed and relationships detected and, provisionally, mapped. Results: The literature review discloses no coherent body of studies into the geo from below, but rather a fragmented amalgam of materials—field observations, primary quotes and occasional elaborations—that are rarely the direct focus of inquiry (except in some contributions by academic geographers). Combining the literature review and the workshop analysis, an outline series of prompts are developed for relating ‘Kinds of Places’, their associated ‘Affective Qualities’ and actual spaces and places on the ground. Conclusions: This study signals what a geopsychiatry from below might entail, providing important foundations for future transdisciplinary work on ‘the geo’ and mental (ill-)health.