bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Association of Substance Use, Psychosocial Factors,
and Suicidal Ideation in Turkish Youth
Authors: Prajapati Parna , Unlu Ali , Pumariega Andres 
Published: January 2024

Objective:
The existing literature on the contribution of substance use
and psychosocial risk factors in the development of suicidal ideation in the
Turkish youth provides limited information. This study aims to compare the
relative association of substance use and psychosocial risk factors with suicidal
ideation in a sample of high school students in Istanbul.

Methods:
High school students were administered a survey of 66 questions in the
school setting. The total number of students surveyed was 31,604 by the Istanbul
Department of Education, and the primary questions and their sub-questions
generated dependent and independent variables that were used in this study. The
relationship between substance use, psychosocial factors, and suicidal ideation
was explored in this study. Logistic regression was used with independent
variables, such as substance use, light users, and heavy users and dependent
variable as suicidal ideation. The variation explained by this model was compared
to the variation explained by the psychosocial factors (age, gender, school type,
immigration status, perceived family affluence, parental education, school grades,
self-esteem scale, faith scale, anomie scale, anxiety scale, depression scale,
irritability scale, antisocial personality scale, time with peers, time with family,
parental involvement, family substance use, and peer influence) while exploring
the strength of the associations for each factor.

Results:
Psychosocial factors explained 33.8 % variance in the dependent
variable, i.e., suicidal ideation, whereas substance use among those participants
explained only 2.2 % variance in predicting suicidal ideation. Restricting analyses
to heavy drug users found a consistently low explained variance of about 1.5 %
of suicidal ideation in this population.

Conclusion:
The psychosocial factors are stronger predictors of suicidal ideation
as compared to the substance use risk factors in a sample of Turkish youth.
Bioinformatics-Assisted Extraction of All PCa miRNAs and their Target
Genes
Authors: Ramu Akilandeswari , Chinnappan Jayaprakash 
Published: January 2024

Introduction:
To retrieve, and classify PCa miRNAs and identify the functional relation-ship between miRNAs and their targets through literature collection with computational analysis.

Background:
MicroRNAs play a role in gene regulation, which can either repress or activate the gene. Hence, the functions of miRNAs are dependent on the target gene. This study will be the first of its kind to combine computational analysis with corpus PCa data. Effectively, our study reported the huge number of miRNAs associated with PCa along with functional information.

Objective:
The identification and classification of previously known full PCa miRNAs and their targets were made possible by mining the literature data. Systems Biology and curated data mining assisted in identifying optimum miRNAs and their target genes for PCa therapy.

Methods:
PubMed database was used to collect the PCa literature up to December 2021. Pub-med.mineR package was used to extract the microRNAs associated articles and manual curation was performed to classify the microRNAs based on the function in PCa. PPI was constructed using the STRING database. Pathway analysis was performed using PANTHER and ToppGene Suite Software. Functional analysis was performed using ShinyGO software. Cluster analysis was per-formed using MCODE 2.0, and Hub gene analysis was performed using cytoHubba. The gene-miRNA network was reconstructed using Cytoscape.

Results:
Unique PCa miRNAs were retrieved and classified from mined PCa literature. Six hundred and five unique miRNAs from 250 articles were considered as oncomiRs to trigger PCa. One hun-dred and twenty unique miRNAs from 118 articles were considered Tumor Suppressor miRNAs to suppress the PCa. Twenty-four unique miRNAs from 22 articles were utilized as treatment miRNAs to treat PCa. miRNAs target genes and their significant pathways, functions and hub genes were identified.

Conclusion:
miR-27a, miR-34b, miR-495, miR-23b, miR-100, miR-218, Let-7a family, miR-27a-5p, miR-34c, miR-34a, miR-143/-145, miR-125b, miR-124 and miR-205 with their target genes AKT1, SRC, CTNNB1, HRAS, MYC and TP53 are significant PCa targets.
Feasible Synthesis of C Fibers@C-MoO2+x Submicro-particles Core-shell Composite for Highly Efficient Solar-driven Photocatalyst
Authors: Chen Yan , Wang Meng , Peng Zhijian , Fu Xiuli 
Published: January 2024

Introduction:
Molybdenum dioxide (MoO2) is attractive due to its applications in optical,
electrical, and new energy fields. However, due to the poor conductivity, pure MoO2 possesses
inferior photocatalytic activity because of the strong recombination between photogenerated electrons
and holes.

Method:
One of the methods to overcome this shortage is to enable nanostructured MoO2 to be
composited with highly conductive materials like carbon fibers. Herein, we fabricate an interesting
C fibers@C-MoO2+x nanoparticle core-shell composite by heat treating Polyacrylonitrile (PAN)
fibers covered with PAN and MoO3 powder in Ar gas, in which the PAN carbonize into conductive
carbon in a heating process and meanwhile, the emitting reducing gases in-situ transform MoO3 to
conducting MoO2+x submicron-particles. Under simulated sunlight irradiation, the photocatalytic
removal rate for rhodamine B, phenol, and K2Cr2O7 on such composite are 11.28, 5.15, and 6.19
times those on commercial MoO2 powder, respectively.

Result:
The prepared composite presents excellent photocatalytic performance and outstanding stability
for degrading various environmental pollutants in water, which will be a good solar-driven
photocatalyst candidate for the degradation of toxic chemicals in industrial wastewater for environmental
remediation.

Conclusion:
Furthermore, this simple preparation strategy represents an easily operated, low-cost,
and environmentally friendly solution for industrial production.
The Association Between Internalized Stigma and Feelings of Loneliness and Quality of Life in Patients with Mental Disorders
Authors: Akhoondi Mohammad , Sadeghian Efat , Aubi Erfan , Shamsaei Farshid 
Published: January 2024

Background:
Individuals with mental disorders are subject to stigma from society.
Some patients accept and internalize this stigma, while others suffer from loneliness
and reduced quality of life.

Objective:
This study aimed to investigate the relationship between internalized stigma,
feelings of loneliness, and quality of life in patients with mental disorders.

Methods:
In 2023, a descriptive study was conducted on 250 patients with psychological
disorders who were referred to Sina Hospital (Farshchian) in Hamadan. The patients were
selected using a convenience sampling method. Data were collected through face-to-face
interviews using four questionnaires: demographic information, the internalized stigma of
mental illness, Russell's loneliness scale, and the World Health Organization's 26-item
quality of life questionnaire. The data were analyzed using descriptive and inferential statistical
tests in SPSS-22 software.

Results:
There was a significant positive correlation between internal stigma and loneliness
(p < 0.001, r = 0.817) and a significant negative correlation between internal stigma
and quality of life (p < 0.001, r = -0.777). Additionally, loneliness and quality of life had a
significant negative correlation (p < 0.001, r = -0.838).

Conclusion:
The results generally indicate that approximately half of the patients with
internalized stigma experience moderate to severe distress. As internalized stigma increases,
patients are more likely to experience feelings of loneliness and decrease their quality
of life. Therefore, it is recommended that measures be taken to reduce internalized stigma
in patients with psychiatric disorders to alleviate feelings of loneliness and improve their
quality of life.
A Review of Nephrotoxins and Their Mechanism of Nephrotoxicity
Authors: Sahu Vaishnavi , Panjwani Dharamveer , Mishra Vibha 
Published: January 2024

:
The harmful impact of substances on renal function is known as nephrotoxicity and the
substance that shows a harmful impact is called nephrotoxins. Nephrotoxins can be classified into
various categories like drugs as nephrotoxins, plant-origin nephrotoxins, environmental toxins, dietary
supplements as nephrotoxins, mycotoxins, pesticides and some infection-causing agents to
act as nephrotoxins. Drugs like cisplatin and aminoglycosides, plants like lemongrass and licorice,
pesticides like alachlor and atrazine, environmental toxins like heavy metals, halogenated aliphatic
hydrocarbons and aromatic halides, mycotoxins like citrinin are the examples of nephrotoxins. The
various mechanisms by which they can cause nephrotoxicity are inflammation, tubular cell necrosis
(drug-induced), hemolysis, vasoconstriction (plant-induced), oxidative stress, enhanced permeability,
encephalopathy (environmental toxins), cysts formation, nephrolithiasis (by dietary supplements),
tubular epithelial degeneration, vascular congestion (pesticides induced) endothelial cell
damage, hypertrophy of tubular cell, increased vascular permeability (infection agents induced),
etc. The abstract provides an overview of the basic groups of nephrotoxins as well as specific examples
and their individual modes of action. It also emphasises the great diversity of substances
and mechanisms that can contribute to nephrotoxicity.
Design, Development and In-Vitro Characterization of Insulin Loaded Topical Pluronic-Lecithin Based Organogel Formulation for the Management of Diabetic Wound
Authors: Chauhan Sunita , Jhawat Vikas , Singh Rahul Pratap , Yadav Abhishek , Garg Vandana 
Published: January 2024

Aim:
To develop and characterize the topical insulin-loaded organogel formulation for
the management of diabetic wounds.

Objectives:
To formulate and evaluate organogel of insulin that can serve as a topical administration
for promoting enhanced wound healing in diabetic patients by providing sustained and localized
delivery of drug to the wound site.

Methodology:
The insulin organogel formulated by the micro-emulsion method involves mixing the
“aqueous and oil phases” at high shear. Physical and chemical properties, as well as an in vitro
study with a Franz diffusion chamber, were used to evaluate the prepared organogel.

Results:
All formulations proved to be off-white, homogeneous, washable, and had a pH between 6
and 6.5; moreover, they were non-irritating and skin-compatible. Formulations F1–F6 had viscosity
ranging from 2058 to 3168 cps, spreadability ranges of 0.35 to 0.52 g*cm/s, and gel transition ranges
of 28.33 to 35.33 °C. In formulations F1–F3, the concentration of lecithin was gradually increased,
and in formulations F4–F6, the concentration of PF-127 was increased, resulting in a decrease
in gel transition temperature, an increase in viscosity, and a gradual change in spreadability.
The higher-viscosity formulations were much more stable and had better drug release. All formulations
were fitted to a kinetic model belonging to first-order kinetics. However, after examining the
parameter evaluation, it was found that the formulations F2 and F6 were better suited to the kinetic
model and were consistent with the first-order and Higuchi models in Korsmeyer-Peppas F2 (r2 =
0.9544 and n = 1.0412); F6 (r2 = 0.9019 and n = 1.0822), which was a confirmation of the sustainability
of the release system with matrix diffusion and drug delivery mechanisms that were based on
the Super-Case II transport.

Conclusion:
Further research and clinical trials are needed to validate its efficacy, optimize the
formulation, and establish its long-term safety. Topical insulin organogel has the potential to revolutionize
diabetic wound management by improving healing outcomes, reducing complications, and
raising the standard of living for those who have diabetes.
Diverse Farming Systems and their Impact on Macro and Microelement Content of Vegetables & Crops
Authors: Rani Madhu , Kapoor Sonia 
Published: January 2024

Background:
The present study investigates the effect of conventional and organic
farming systems on the nutritional profile of crops. Different crops, namely –millet, sorghum,
sesame, mustard, fenugreek, berseem, pea, potato, and onion were cultivated through conventional agriculture in which chemical fertilizers like urea, DAP (Diammonium Phosphate) and
pesticides were used and organic farming in which organic fertilizers like seaweed and vermicompost were used.

Objective:
The experimental study was done on a field in north India from 2019 to 2021 in six
different seasons, and the nutrient profile of the crops with respect to macroelements (S, K, Na,
P, Ca, Mg) and microelements (B, Cu, Fe, Mn, Zn, Al) was compared.

Methods:
Macro and microelements were analyzed by Element analyzer and ICP-OES in both
types of farming systems. The content of macro, as well as microelements, was found to be significantly higher in all the organically produced crops as compared to the conventionally grown
crops.

Results:
Significant differences were observed in the macroelement content of organic onion (P900 mg/kg, K-2000mg/kg) and organic pea (K 2250 mg/kg) as compared to the content of conventionally grown onion (P-756 mg/kg, K- 1550 mg/kg) and pea (K-2000 mg/kg). Similarly,
microelement content in the organic sesame (Fe - 3.12 mg/kg), organic millet (Fe- 2.19 mg/kg),
and organic potato (Zn-200 mg/kg) was higher as compared to conventionally grown sesame (Fe
2.05 mg/kg), millet (Fe- 1.56 mg/kg) and potato (Zn 167 mg/kg).

Conclusion:
This investigation concludes that crops with optimum nutritional content can be
produced through organic farming with minimum input and maximum production.
Use of Digital COVID-19 Exposure Notifications at a Large Gathering: Survey Analysis of Public Health Conference Attendees
Authors: Drover Caitlin M , Elder Adam S , Guthrie Brandon L , Revere Debra , Briggs Nicole L , West Laura M , Higgins Amanda , Lober William B , Karras Bryant T , Baseman Janet G 
Published: January 2024

Background
WA Notify was Washington State’s smartphone-based COVID-19 digital exposure notification (EN) tool, which was used to help limit the spread of COVID-19 between November 30, 2020, and May 11, 2023. Following the 2022 Washington State Public Health Association Annual Conference, attendees who had WA Notify activated began receiving ENs alerting them to a possible COVID-19 exposure during the conference. A survey was emailed to all conference attendees to measure WA Notify adoption, mechanisms through which attendees received ENs, and self-reported engagement in protective behaviors postexposure.

Objective
This study aimed to learn more about the experiences of WA Notify adopters and nonadopters who may have been exposed to COVID-19 at a large group gathering.

Methods
A web-based survey administered through REDCap (Research Electronic Data Capture; Vanderbilt University) was sent to all attendees of the Washington State Public Health Association conference. Self-reported demographic information and characteristics of respondents were summarized. Regression models were used to estimate relative risks to compare WA Notify adoption and testing behaviors between groups.

Results
Of the 464 total registered attendees who were sent the survey, 205 (44%) responses were received; 201 eligible attendees were included in this analysis. Of those, 149 (74%) respondents reported having WA Notify activated on their phones at the time of the conference. Among respondents with WA Notify activated, 54% (n=77) reported learning of their potential exposure from a WA Notify EN. Respondents who reported that they did not have WA Notify activated and learned of their potential exposure via the event-wide email from conference organizers were 39% less likely to test for COVID-19 compared to respondents with WA Notify activated who learned of their potential exposure from the email (relative risk 0.61, 95% CI 0.40-0.93; P=.02), and this gap was even larger when compared to respondents who learned of their exposure from a WA Notify EN. The most commonly cited reason for not having WA Notify activated was privacy concerns (n=17, 35%), followed by not wanting to receive ENs (n=6, 12%) and being unaware of WA Notify (n=5, 10%).

Conclusions
Digital EN systems are an important tool to directly and anonymously notify close contacts of potential exposures and provide guidance on the next steps in a timely manner. Given the privacy concerns, there is still a need for increasing transparency surrounding EN technology to increase uptake by the public if this technology were to be used in the future to slow the spread of communicable diseases.
Addressing Cyberscams and Acquired Brain Injury (“I Desperately Need to Know What to Do”): Qualitative Exploration of Clinicians’ and Service Providers’ Perspectives
Authors: Chew Kimberly Ann , Ponsford Jennie , Gould Kate Rachel 
Published: January 2024

Background
People with acquired brain injury (ABI) may be more susceptible to scams owing to postinjury cognitive and psychosocial consequences. Cyberscams result in financial loss and debilitating psychological impacts such as shame and mistrust, interference with neurorehabilitation, and reduced independence. Despite these significant consequences, there are no psychological treatments to support cyberscam survivors. There is limited evidence regarding how the current workforce is addressing post-ABI cyberscams.

Objective
This study aims to understand the perspectives and needs of clinicians and service providers in addressing post-ABI cyberscams.

Methods
Overall, 20 multidisciplinary clinicians and service providers were recruited through purposive sampling across Australia. Semistructured interviews explored post-ABI scam experiences and vulnerabilities, treatments and their efficacy, and recommendations for future cybersafety recovery interventions. Reflexive thematic analysis was used.

Results
In total, 8 themes encompassing a biopsychosocial understanding of scam vulnerabilities and impacts were identified: “genuine lack of awareness: cognitive-executive difficulties”; “not coping with the loss of it all”; “needing trust and connection”; “strong reactions of trusted others”; “nothing structured to do”; “financial stress and independence”; “cyberability”; and “scammer persuasion.” Each theme informed clinical recommendations including the need to provide psychological and cognitive support, enhance financial and cybersafety skills, promote meaningful social engagement, and foster collaboration between families and clinical support teams.

Conclusions
The multifaceted range of scam vulnerabilities and impacts highlighted the need for individualized, comprehensive, and targeted treatments using a biopsychosocial approach to enable cyberscam recovery among people with ABI. These findings will guide the development of a co-designed intervention.
The Impact of the Ecosystem on Health Literacy Among Rural Communities in Protected Areas: Protocol for a Mixed Methods Study
Authors: Abd Kadir Nor Aziah , Azzeri Amirah , Jaafar Hafiz , Mohd Noor Mohd Iqbal , Kefeli Zurina 
Published: January 2024

Background
Protected areas are crucial for the maintenance of human health and well-being. They aim to preserve biodiversity and natural resources to secure various ecosystem services that are beneficial to human health. Their ecological characteristics can influence local health literacy. Typically, communities surrounding protected areas have limited economic opportunities due to restriction policies to protect the ecosystem, resulting in socioeconomic disparities. The local community faces obstacles in gaining access to health care facilities and health information due to these limitations. It is difficult for them to locate, comprehend, and apply information and services to make better health-related decisions for themselves and others.

Objective
This study protocol examines the impact of the ecosystem on health literacy among rural communities in protected areas.

Methods
This study comprises 5 phases. In phase 1, we conduct a systematic review to identify the issue of health literacy in protected areas. In phase 2, we will collect data from stakeholders in a protected area of Pahang National Park and analyze the results using Net-Map analysis. In phase 3, we will conduct a survey among the adult community in Pahang National Park related to health literacy, socioeconomic status, health expenditure, and quality of life. In phase 4, informed by the results of the survey, we will determine suitable intervention programs to improve health literacy through a focus group discussion. Finally, in phase 5, we will conduct a costing analysis to analyze which intervention program is the most cost-effective.

Results
This study was funded by Universiti Sains Islam Malaysia (USIM) and strategic research partnership grants, and enrollment is ongoing. The first results are expected to be submitted for publication in 2024.

Conclusions
This is one of the first studies to explore health literacy among rural communities in protected areas and will provide the first insights into the overall level of health literacy in the protected community, potential determinants, and a suitable intervention program with expected cost analysis. The results can be used to promote health literacy in other protected areas and populations.

Trial Registration
International Standard Randomized Controlled Trial Number Registry ISRCTN40626062; http://tinyurl.com/4kjxuwk5

International Registered Report Identifier (IRRID)
PRR1-10.2196/51851
Калмыцкая степь Астраханской губернии в первой половине XIX в.: этапы и основные модели административной системы управления
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Gunaev Evgeniy A. 
Published: January 2024

Introduction. The article deals with some key stages and patterns of administrative governance sequentially adopted for Kalmyk Steppe of Astrakhan Governorate in the early-to-mid nineteenth century. This very period was witnessing the integration and incorporation of Kalmyk Steppe into Russia’s administrative system, though some ethnos-specific governance elements would still be retained. The related historiography contains no explicit data as to certain governance stages (and patterns) characterized by corresponding qualitative changes. Results. The paper examines the publication titled ‘Ministry of State Property over the Fifty Years, 1837–1887: A Historical Review’ (Pt. 2: Protectorship. Land Affairs) for provisions pertaining to the governance system in Kalmyk Steppe. According to the document, efforts of the Russian Government across Kalmyk Steppe in the early-to-mid nineteenth century were primarily aimed at: 1) interacting with ethnic elites, endowing the latter with certain rights and privileges, involving them into the imperial power hierarchy at regional and local levels; 2) introducing (step by step) imperial legislative and court practices (common-law norms remain in force at lower levels for civil circulation); 3) laying foundations of imperial financial and tax policies (given that local elites would retain their original privileges). Conclusions. Our insights into opinions and viewpoints of contemporary researchers have identified a number of distinct features inherent to the shaping and functioning of the administrative governance system in early-to-mid nineteenth century Kalmyk Steppe. So, the early nineteenth century namestnichestvo was essentially rather that of the late eighteenth century. At the same time, pristavstvo should be viewed only as a milestone towards popechitelstvo. In general, the three can still be considered as individual governance patterns — with differing governance objects. However, the basis was compiled from supervision and wardship, and preservation of some ethnic governance traditions.