bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using urine FTIR spectra to screen autism spectrum disorder
Authors: Sarigul Neslihan , Bozatli Leyla , Kurultak Ilhan , Korkmaz Filiz 
Published: November 2023

AbstractAutism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder caused by multiple factors, lacking clear biomarkers. Diagnosing ASD still relies on behavioural and developmental signs and usually requires lengthy observation periods, all of which are demanding for both clinicians and parents. Although many studies have revealed valuable knowledge in this field, no clearly defined, practical, and widely acceptable diagnostic tool exists. In this study, 26 children with ASD (ASD+), aged 3–5 years, and 26 sex and age-matched controls are studied to investigate the diagnostic potential of the Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy. The urine FTIR spectrum results show a downward trend in the 3000–2600/cm region for ASD+ children when compared to the typically developing (TD) children of the same age. The average area of this region is 25% less in ASD+ level 3 children, 29% less in ASD+ level 2 children, and 16% less in ASD+ level 1 children compared to that of the TD children. Principal component analysis was applied to the two groups using the entire spectrum window and five peaks were identified for further analysis. The correlation between the peaks and natural urine components is validated by artificial urine solutions. Less-than-normal levels of uric acid, phosphate groups, and ammonium ($${NH}_{4}^{+}$$

NH

4

+

) can be listed as probable causes. This study shows that ATR-FTIR can serve as a practical and non-invasive method to screen ASD using the high-frequency region of the urine spectrum.
Crystallizing covalent organic frameworks from metal organic framework through chemical induced-phase engineering
Authors: Mohammed Abdul Khayum , Gaber Safa , Raya Jésus , Skorjanc Tina , Elmerhi Nada , Stephen Sasi , Sánchez Pilar Pena , Gándara Felipe , Hinder Steven J. , Baker Mark A. , Polychronopoulou Kyriaki , Shetty Dinesh 
Published: November 2023

AbstractThe ordered porous frameworks like MOFs and COFs are generally constructed using the monomers through distinctive metal-coordinated and covalent linkages. Meanwhile, the inter-structural transition between each class of these porous materials is an under-explored research area. However, such altered frameworks are expected to have exciting features compared to their pristine versions. Herein, we have demonstrated a chemical-induction phase-engineering strategy to transform a two-dimensional conjugated Cu-based SA-MOF (Cu-Tp) into 2D-COFs (Cu-TpCOFs). The structural phase transition offered in-situ pore size engineering from 1.1 nm to 1.5–2.0 nm. Moreover, the Cu-TpCOFs showed uniform and low percentage-doped (~ 1–1.5%) metal distribution and improved crystallinity, porosity, and stability compared to the parent Cu-Tp MOF. The construction of a framework from another framework with new linkages opens interesting opportunities for phase-engineering.
Laminar compartmentalization of attention modulation in area V4 aligns with the demands of visual processing hierarchy in the cortex
Authors: Wang Xiang , Nandy Anirvan S. , Jadi Monika P. 
Published: November 2023

AbstractAttention selectively enhances neural responses to low contrast stimuli in visual area V4, a critical hub that sends projections both up and down the visual hierarchy. Veridical encoding of contrast information is a key computation in early visual areas, while later stages encoding higher level features benefit from improved sensitivity to low contrast. How area V4 meets these distinct information processing demands in the attentive state is unknown. We found that attentional modulation in V4 is cortical layer and cell-class specific. Putative excitatory neurons in the superficial layers show enhanced boosting of low contrast information, while those of deep layers exhibit contrast-independent scaling. Computational modeling suggested the extent of spatial integration of inhibitory neurons as the mechanism behind such laminar differences. Considering that superficial neurons are known to project to higher areas and deep layers to early visual areas, our findings suggest that the interactions between attention and contrast in V4 are compartmentalized, in alignment with the demands of the visual processing hierarchy.
Temperature-dependent photo-elastic coefficient of silicon at 1550 nm
Authors: Dickmann Johannes , Meyer Jan , Gaedtke Mika , Kroker Stefanie 
Published: November 2023

AbstractThis paper presents a study on the temperature dependent photo-elastic coefficient in single-crystal silicon with (100) and (110) orientations at a wavelength of 1550 nm. The measurement of the photo-elastic coefficient was performed using a polarimetric scheme across a wide temperature range from 5 to 300 K. The experimental setup employed high-sensitivity techniques and incorporated automatic beam path correction, ensuring precise and accurate determination of the coefficient’s values. The results show excellent agreement with previous measurements at room temperature, specifically yielding a value of $$dn/d\sigma = -2.463 \times 10^{-11}$$

d
n
/
d
σ
=
-
2.463
×

10

-
11

1/Pa for the (100) orientation. Interestingly, there is a significant difference in photo-elasticity between the different crystal orientations of approximately $$50\%$$

50
%

. The photo-elastic coefficient’s absolute value increases by approximately 40% with decreasing temperature down to 5 K. These findings provide valuable insights into the photo-elastic properties of silicon and its behavior under varying mechanical stress, particularly relevant for optomechanical precision experiments like cryogenic gravitational wave detectors and microscale optomechanical quantum sensors.
Fractional optimal control strategies for hepatitis B virus infection with cost-effectiveness analysis
Authors: Dano Lemesa Bedjisa , Koya Purnachandra Rao , Keno Temesgen Duressa 
Published: November 2023

AbstractHepatitis B disease is a communicable disease that is caused by the hepatitis B virus and has become a significant health problem in the world. It is a contagious disease that is transmittable from person to person either horizontally or vertically. This current study is aimed at sensitivity analysis and optimal control strategies for a fractional hepatitis B epidemic model with a saturated incidence rate in the sense of the Caputo order fractional derivative approach. Fundamental properties of the proposed fractional order model are obtained and discussed. A detailed analysis of disease-free equilibrium and endemic equilibrium points is given by applying fractional calculus theory, which is a generalized version of classical calculus. Sensitivity indexes are calculated for the classical order model. Illustrative graphics that show the dependence of the sensitivity index on fractional order derivative for $$\alpha \in (0,1)$$

α
∈
(
0
,
1
)

are provided. Based on the results of the sensitivity analysis and using Pontryagin’s Maximum Principle, optimal control strategies for preventing hepatitis B infection with vaccination and treatment are considered. Fractional Euler’s method is used to carry out the numerical simulation for the proposed fractional optimal control system and the obtained results are analyzed. The results of the analysis reveal that hepatitis B disease can be prevented if necessary precautionary is taken or effective vaccination and treatment control measures are applied. The analysis of cost-effectiveness is also conducted and discussed.
‘Inert’ co-formulants of a fungicide mediate acute effects on honey bee learning performance
Authors: DesJardins Nicole S. , Macias Jessalynn , Soto Soto Daniela , Harrison Jon F. , Smith Brian H. 
Published: November 2023

AbstractManaged honey bees have experienced high rates of colony loss recently, with pesticide exposure as a major cause. While pesticides can be lethal at high doses, lower doses can produce sublethal effects, which may substantially weaken colonies. Impaired learning performance is a behavioral sublethal effect, and is often present in bees exposed to insecticides. However, the effects of other pesticides (such as fungicides) on honey bee learning are understudied, as are the effects of pesticide formulations versus active ingredients. Here, we investigated the effects of acute exposure to the fungicide formulation Pristine (active ingredients: 25.2% boscalid, 12.8% pyraclostrobin) on honey bee olfactory learning performance in the proboscis extension reflex (PER) assay. We also exposed a subset of bees to only the active ingredients to test which formulation component(s) were driving the learning effects. We found that the formulation produced negative effects on memory, but this effect was not present in bees fed only boscalid and pyraclostrobin. This suggests that the trade secret “other ingredients” in the formulation mediated the learning effects, either through exerting their own toxic effects or by increasing the toxicities of the active ingredients. These results show that pesticide co-formulants should not be assumed inert and should instead be included when assessing pesticide risks.
Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur
Authors: Agarwal Deepak , Kumar Gulshan , Ashraf Rather Mohd , Ahmad Ishtiyaq 
Published: November 2023

AbstractThe cloning and characterization of the complete coding sequence of the Clarias magur SRD5A1 (CmSRD5A1) gene, which encodes an enzyme responsible for regulating steroid levels by converting testosterone into 5α-dihydrotestosterone (DHT), have been successfully achieved. DHT plays a vital role in enabling the complete expression of testosterone's actions in neuroendocrine tissues. The ORF of the full-length cDNA sequence of SRD5A1 was 795 bp, translating into 265 amino acids, with a total length of 836 bp including UTRs. Like other vertebrates, the signal peptide analysis revealed that SRD5A1 is a non-secretory protein, and hydropathy profiles indicated that it is hydrophobic in nature. The 3D structure of CmSRD5A1 sequence generated above was predicted using highly accurate AlphaFold 2 in Google Colab online platform. CmSRD5A1 contains seven transmembrane helices connected by six loops, with the N-termini located on the periplasmic side and C-termini on the cytosolic side. Structural superimposition with known bacterial and human SRD5As showed very high structural similarity. The electrostatic potential calculation and surface analysis of CmSRD5A1 revealed the presence of a large cavity with two openings one highly electropositive towards the cytosolic side and another relatively neutral towards the transmembrane region. The structural comparison revealed that the electropositive side of the cavity should bind to NADPH and the steroid hormone in the hydrophobic environment. Polar residues binding to NADPH are highly conserved and the same as known strictures. The conserved residues involved in hydrogen bonding with the ketone group at C-3 in the steroids hence fevering Δ4 double-bond reduction are identified as E66 and Y101. Our findings showed that SRD5A1 expression was lower during the spawning phase than the preparatory phase in female fish, while the administration of Ovatide (a GnRH analogue) resulted in up-regulation of expression after 6 h of injection in the ovary. In males, the lowest expression was observed during the preparatory phase and peaked at 16 h post- Ovatide injection in the testis. The expression of SRD5A1 in the brain of female fish was slightly higher during the Ovatide stimulation phase than the spawning phase. This study represents the first report on the cloning and characterization of the full-length cDNA of SRD5A1 in Indian catfish.
Molecular and virulence characteristics of carbapenem-resistant Acinetobacter baumannii isolates: a prospective cohort study
Authors: Park Seung Min , Suh Jin Woong , Ju Yong Kuk , Kim Jeong Yeon , Kim Sun Bean , Sohn Jang Wook , Yoon Young Kyung 
Published: November 2023

AbstractThis study aimed to characterize the molecular features and virulence profiles of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. Clinical CRAB isolates were obtained from blood cultures of adult patients with CRAB bacteremia, collected between July 2015 and July 2021 at a Korean hospital. Real-time polymerase chain reaction was used to detect 13 virulence genes, genotyping was conducted via multilocus sequence typing (MLST), and a Tenebrio molitor infection model was selected for survival analysis. Herein, 170 patients, from whom CRAB isolates were collected, showed the in-hospital mortality rate of 57.6%. All 170 clinical CRAB isolates harbored blaOXA-23 and blaOXA-51. MLST genotyping identified 11 CRAB sequence types (STs), of which ST191 was predominant (25.7%). Virulence genes were distributed as follows: basD, 58.9%; espA, 15.9%; bap, 92.4%; and ompA, 77.1%. In the T. molitor model, ST195 showed a significantly higher mortality rate (73.3% vs. 66.7%, p = 0.015) than the other groups. Our findings provide insights into the microbiological features of CRAB blood isolates associated with high mortality. We suggest a potential framework for using a T. molitor infection model to characterize CRAB virulence. Further research is warranted to elucidate the mechanisms by which virulence improves clinical outcomes.
Parameter identification of transformer lumped element network model through genetic algorithm‐based gray‐box modelling technique
Authors: Cheng Bozhi , Yang Yaoxian , Shen Shuhang , Wang Zhongdong , Crossley Peter , Wilson Gordon , Fieldsend‐Roxborough Andrew 
Published: November 2023

AbstractThe lumped element network model has been proven to be an efficient tool for the interpretation of transformer Frequency Response Analysis. However, it is challenging to obtain parameters of the model if transformer design information is unavailable. In such a case, optimisation algorithms can be used for gray‐box model parameter estimation. A methodology is developed by the authors to establish a transformer network model without winding design data, and instead, end‐to‐end open circuit Frequency Response and other terminal test results are utilised; and Genetic Algorithm is applied to approximate the unknown parameters of the model. The modelling approach developed is independent of the unit number of the network model and therefore guarantees the accuracy of optimisation. Furthermore, it can deal with transformers with a complicated winding structure such as interleaved disc type winding. Two single windings, helical and interleaved disc type, and a single‐phase 144/13 kV 60 MVA transformer are used to demonstrate the method. FRA spectra produced by the best estimated gray‐box model and the corresponding white‐box model are compared. The main features in amplitude and phase spectra are well matched, with low values of Relative Standard Deviation, for both single windings and transformer. Estimated electrical parameters show a high consistency with reference values, which are calculated based on winding design data. This validates the methodology and gives confidence to apply grey‐box modelling for FRA interpretation.
COVID-19 and Spontaneous Resolution of Lumbar Disk Prolapse: A Retrospective Cohort Study of Patients Awaiting Microdiscectomy
Authors: Hutton Dana , Mohamed Belal , Mehmood Khalid , Magro James , Shekhar Himanshu , Solth Anna , Pulhorn Heinke , Bennett David , Okasha Mohamed 
Published: November 2023

Abstract
Background Between individual patients with lumbar disk prolapse (LDP), the natural course of disease is significantly variable. Spontaneous resolution is reported to occur in up to 70% of cases. However, we currently cannot predict for whom and when this will occur. Neurosurgical intervention is indicated for LDP patients with nontolerable pain after at least 8 to 12 weeks of conservative management, or significant neurologic deficit. Channeling essential resources in the National Health Service (NHS) to fight the COVID-19 pandemic led to the postponement of most elective operations, including microdiskectomy. This left many LDP patients previously considered to be surgical candidates with conservative-only options in the interim. To our knowledge, we are the first center to report the specific impact of the peri- and postpandemic period on waiting list times, delayed elective microdiskectomy, and the incidence of spontaneous LDP resolution.
Methods Retrospective case series of a prospectively collected electronic departmental database identified LDP patients who would have been impacted by the COVID-19 pandemic at some point in their care pathway (March 2020–February 2022). Further information was obtained from electronic patient records.
Results In total, 139 LDP patients were listed for elective microdiskectomy at the time of postponement of elective surgery. Over a third of LDP patients (n = 47, 33.8%), in shared decision with the responsible neurosurgeon, had their rescheduled microdiskectomy canceled due to clinical improvement (14.1%), radiologic regression (6.5%), or both (12.2%).
Conclusion Our single-center retrospective analysis revealed that for over a third of LDP patients, the prolonged postpandemic waiting list times for elective microdiskectomy resulted in their surgery not taking place either due to spontaneous clinical improvement or proven radiologic regression. Considering this, a prolonged conservative approach to LDP may be appropriate in some patients, allowing time for natural resolution, while avoiding perioperative risks.
Neonatal Sacrococcygeal Fetiform Teratoma Containing Bowel: A Case Report
Authors: Toms Ashley , Govender Tarlia Rasa , Brisighelli Giulia , Harrison Derek 
Published: November 2023

AbstractA fetiform sacrococcygeal teratoma (homunculus) is a highly differentiated subgroup of mature cystic teratoma that resembles a malformed fetus. These tumors originate at the base of the coccyx and may vary in their intrapelvic and extrapelvic extent and location. It is important to differentiate this anomaly from fetus-in-fetu which has a higher degree of structural organization. A 5-day-old neonate presented with a type II sacrococcygeal fetiform teratoma. The mass contained both cystic and solid components. Upon surgical excision and coccygectomy, fully formed bowel was found inside the mass, as well as bones and other well-defined structures. The tumor was confirmed to be fully excised and no malignant or immature features were found on histopathological examination. The patient was last seen growing well with an alpha-fetoprotein of 3.5 μg/L, 14 months after resection.
Carry on Caesar
Authors: Ranzato Irene 
Published: November 2023

Abstract
The variations on broadly fixed formulas used to represent such characters as the one portraying the Roman emperor, Julius Caesar, are all the more conspicuous for their, sometimes, almost imperceptible nuances. This article will illustrate some meaningful examples of filmic Caesars, focusing on the linguistic representation of this character, often handled as a stock character. The larger definition of stock characters, which includes but is not limited to stereotypes, encompasses a set of both visual and linguistic formulaic features which depend on identity constructions or social positions, to put it in Quantz’s terms (2015). The character Julius Caesar is often made to follow what film historians have called a general ‘linguistic paradigm’, by which British actors with posh accents, in post-war Hollywood epics of the 1950s, are frequently cast as wicked Roman tyrants or simply as members of the establishment opposed by the ‘hero’ of the tale. Departures from a schema can be however just as revealing in order to pinpoint recurrent themes, and they will be explored by focusing on the comic rendition of Caesar as interpreted by Kenneth Williams in the 1964 British comedy Carry on Cleo, and on the analysis of its outrageously racist and sexist Italian translation.
Accessibility and reception studies at the Macerata Opera Festival
Authors: Raffi Francesca 
Published: November 2023

Abstract
This essay discusses an audience reception study carried out within the framework of media accessibility to
evaluate the experience of blind/partially sighted patrons and their (sighted) accompanying persons in the context of the Macerata
Opera Festival (MOF). Adopting a qualitative analytical approach, feedback was collected from individuals in the sample who
completed post-hoc self-report questionnaires, and three interdependent variables were measured: (a) comprehension and recall, (b) cognitive load, and (c) psychological immersion. This qualitative analysis was combined with a descriptive methodology, using
attitudinal data to evaluate the lived experience of individuals, notably their appreciation and preferences. Results revealed
that there was no substantial divergence in the values of the variables recorded for the two groups in the sample: blind/partially
sighted and sighted (accompanying) patrons. Additionally, audio descriptions and tactile tours increased psychological immersion,
without provoking cognitive overload. Furthermore, high levels of appreciation and preferences were related to comprehension and
recall, cognitive load, and psychological immersion. This confirms the effectiveness of audio descriptions and tactile tours in
enhancing the engagement and empowerment of blind/partially sighted members of the audience.
Evaluating the Efficacy of Dedifferentiated Fat Cells (DFATs) vs Adipose-Derived Stem Cells (ASCs) in Enhancing the Viability of Fat Grafts
Authors: Zhu Jinglin , Zhao Fangning , Chai Yimeng , Jia Xinyu , Li Facheng 
Published: November 2023

Abstract

Background
Enhancing graft fat survival remains a paramount challenge in autologous fat transplantation surgeries. Dedifferentiated fat cells (DFATs) and adipose-derived stem cells (ASCs) represent 2 pivotal cells with potential to improve fat graft survival rates.

Objectives
In this study we aimed to compare the effectiveness of DFATs and ASCs in promoting fat graft survival, emphasizing their adipogenic and angiogenic capabilities.

Methods
Both in vitro and in vivo experiments were conducted. In vitro assessments compared adipogenesis, angiogenesis, osteogenesis, chondrogenesis, cell migration abilities, and surface markers. For in vivo evaluation, a cell-assisted lipotransfer animal model was employed to gauge graft volume retention and histological morphology. Analysis techniques included hematoxylin and eosin staining, Western blotting, and real-time polymerase chain reaction.

Results
In vitro findings suggested a slight superiority of DFATs in adipogenesis and angiogenesis compared to ASCs. In vivo tests demonstrated both cell types surpassed the control in terms of graft volume retention, with the DFATs group marginally outperforming in retention rates and the ASC group presenting a slightly enhanced graft tissue structure.

Conclusions
Our study underscores the distinct advantages of DFATs and ASCs in bolstering fat graft survival, offering potentially novel insights for plastic surgeons aiming to elevate fat graft survival rates.