bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for Mortality in Patients with COVID-19 in CuernavacaMorelos
Authors: Hernández Jorge Martín Rodríguez , Hernández Cidronio Albavera , Troya Arsenio Hidalgo , Garzón Flor Stella Piñeros , Rojas Sarahi Rodríguez 
Published: January 2025

Background:
The world changed in December 2019 due to respiratory tract infection
cases, initially of unknown etiology, later known as COVID-19.

Objective:
This study aimed to determine the factors and comorbidities associated with mortality
from COVID-19 in Mexico.

Methods:
It was a cross-sectional and observational prospective study of patients treated at an
IMSS (Mexican Institute of Social Security) Hospital in Morelos with a confirmed diagnosis of
COVID-19. Logistic regression models and survival analyses were developed to identify factors
associated with mortality risk.

Results:
3,965 patients were analyzed, with most deaths occurring in men. The mortality risks
were higher in men who were older than 50 years. The most significant associations were: age older than 80 years (HR:3.17), endotracheal intubation (HR:1.54), dyspnea (HR: 13.55), and polypnea (HR:1.54).

result:
3,965 patients with COVID-19 were analyzed. Most of the deceased were men. The instantaneous risk of mortality from COVID-19 was higher in men older than 50 years. The variables with the most significant association were age older than 80 years (HR:3.17), endotracheal intubation (HR:1.54), dyspnea (HR: 13.55), and polypnea (HR:1.54).

Conclusion:
The risk of death in this population was high, considering the absence of primary protective measures at the beginning of the pandemic and the lack of consistency in using personal
protection elements.
Exploring the Involvement of New Members of the Interleukin Family in Cardiovascular Disease
Authors: Al Noman Abdullah , Flora Sanzida Alam , Datta Monty , afrose Fahmida , Binte Hasan Nushaiba , Akhter Tahamina , Anuva Nayeema Jameel , Pathak Rashmi , Sharma Himanshu 
Published: January 2025

Abstract:
Cardiovascular diseases remain a significant reason for illness and death globally.
Although certain interleukins have been extensively researched about cardiovascular disease
(CVD), new findings have identified unique members of the interleukin family that could potentially
play a role in cardiovascular well-being and ailments. This review discusses the current
understanding of the role of these recently identified interleukins, such as IL-27, IL-31, IL-32,
IL-33, and the IL-28 group (IL-28A, IL-28B, IL-29), in the development of cardiovascular diseases.
Every interleukin has various impacts achieved through particular receptors and signaling
pathways that affect inflammatory processes, differentiation of immune cells, and the functioning
of blood vessels. IL-27 controls the development of inflammatory Th17 cells and might decrease
inflammation in atherosclerosis. IL-31 plays a role in the interaction between the immune
system and nerves, as well as in itching. IL-32 enhances the generation of inflammatory proteins
and has been linked to coronary artery disease. IL-33 has beneficial effects on the cardiovascular
system, whereas its imitation receptor sST2 could potentially be used as a biomarker. Additional
studies are needed to investigate the antiviral and immune-system regulating effects of the IL-28
group in cardiovascular diseases. In general, explaining the ways in which new interleukins contribute
to the progression of cardiovascular diseases can help discover fresh targets for therapy
and new approaches toward enhancing the prevention and treatment of heart disorders. Additional
research on the way these cytokines engage with established disease pathways is necessary.
Deep Learning-assisted Diagnosis of Extrahepatic Common Bile Duct Obstruction Using MRCP Imaging and Clinical Parameters
Authors: Thoi Do Kieu Trang , Lim Jung Hyun , Park Jin-Seok , Park Suhyun 
Published: January 2025

Background:
Extrahepatic Common Bile Duct Obstruction (EHBDO) is a serious condition that requires accurate diagnosis for effective treatment. Magnetic
Resonance Cholangiopancreatography (MRCP) is a widely used noninvasive imaging technique for visualizing bile ducts, but its interpretation can
be complex.

Objective:
This study aimed to develop a deep learning-based classification model that integrates MRCP images and clinical parameters to assist radiologists
in diagnosing EHBDO more accurately.

Methods:
A total of 465 patients with clinical data were included, of whom 143 also had MRCP images. Missing clinical values were addressed through data
imputation. Object detection techniques were used to isolate the common bile duct region in the MRCP images. A multimodal deep learning fusion
model was developed by combining the extracted imaging features with selected clinical parameters. To account for the varying significance of
different features, a weighted loss function was applied. The performance of the fusion model was compared to that of single-modality approaches
(using only MRCP images or clinical data), specifically the accuracy, sensitivity, specificity, and Area Under The Curve (AUC).

Results:
The performance of the proposed deep learning fusion model was superior to that of models using only MRCP images or clinical parameters. The
fusion model achieved an accuracy of 89.8%, AUC of 90.4%, sensitivity of 81.8%, and specificity of 95.7% in diagnosing EHBDO. By integrating
MRCP imaging data and clinical parameters, the proposed deep learning model significantly enhanced the accuracy of EHBDO diagnosis.

Conclusion:
This proposed multimodal approach outperformed traditional single-modality methods, presenting a valuable tool for improving the diagnostic
accuracy of bile duct obstruction.
Comparative Study on Sedative and Hypnotic Effects of Crude and Parched Semen Ziziphi Spinosae: Integration of Network Pharmacology and In Vivo Pharmacological Evaluation
Authors: Xia Jing , Cai Ming , Xu Bo , Xie Guang-Jing , Wang Ping 
Published: January 2025

Objective:
This study aimed to investigate the medicinal properties of SZS before and
after processing and provide novel insights into its potential for treating insomnia.

Methods:
This study employed the network pharmacology platform to gather information on the
chemical composition of SZS, human targets, genes, molecular networks, and pathways associated
with insomnia treatment using SZS. Liquid chromatography-tandem mass spectrometry (LC-MS/
MS) was utilized to analyze the chemical profiles of crude SZS, parched SZS, and their combined
decoction. The effects of different SZS products on p-chlorophenylalanine-induced insomnia
mice were evaluated through pentobarbital-induced sleep tests, behavioral analyses, examination
of brain tissue-related mRNA levels, and measurement of plasma neurotransmitters, aiming
to explore the sedative and hypnotic effects of various SZS products.

Results:
SZS was found to contain a total of 47 genes, including 22 target genes associated with
insomnia. These genes may contribute to the sedative and hypnotic effects through 9 related pathways
and 69 biological processes. The active components of SZS remained consistent before and
after processing. Jujuboside B was found in higher concentrations in crude SZS, while jujuboside
A was more abundant in parched SZS. Additionally, SZS exhibited reduced locomotor activity in
mice, enhanced the hypnotic effect of pentobarbital sodium, and decreased the levels of acetylcholinesterase,
α-1B adrenergic receptor, and solute carrier family 6 member 4 mRNA in the cortex
and hippocampus of mice. The levels of acetylcholine, choline acetyltransferase, 5-hydroxyindoleacetic
acid, and glutamate in plasma increased, with the hypnotic effect being proportional to
the dosage of the drug.

Conclusion:
SZS demonstrates sedative and hypnotic effects, potentially mediated by its influence
on neurotransmitter levels and related receptors within the central nervous system. There was
a slight variation in regulatory capabilities before and after SZS processing, with the combined decoction
of crude and parched SZS exhibiting a more pronounced effect, particularly at higher
dosages.

conclusion:
SZS demonstrates sedative and hypnotic effects, potentially mediated by its influence on neurotransmitter levels and related receptors within the central nervous system. There was a slight variation in regulatory capabilities before and after SZS processing, with the combined decoction of crude and parched SZS exhibiting a more pronounced effect, particularly at higher dosages.
Microbial Communities in Coastal Salt Marshes Along the Southeast Coast of China and Their Effects on Carbon Storage
Authors: Lv Chunguang , Li Yan , Wang Chenyi , Zhang Huining , Ren Min , Zhang Chiqian 
Published: January 2025

Background:
Wetlands are vital carbon sinks, with coastal salt marshes being particularly
effective in carbon sequestration. Understanding how different vegetation types influence soil carbon
storage and microbial composition can enhance our knowledge of these ecosystems’ roles in global
carbon cycling.

Methods:
This study investigates soil physicochemical properties, soil carbon storage, and microbial
community composition and diversity at three depths (10, 30, and 60 cm) in five salt marsh plots
from five coastal salt marshes: Bare flat (a non-vegetated marsh) and plots dominated by Imperata
cylindrica, Solidago canadensis, Suaeda spp., and Phragmites australis. Carbon storage was evaluated
by measuring soil organic carbon (SOC) content. At the same time, high-throughput sequencing
was employed to analyze microbial communities, aiming to elucidate their relationships with soil
carbon storage and wetland vegetation.

Results:
The average SOC contents in the five plots were in the order of S. canadensis (13.33 g·kg–
1) > Bare flat (11.45 g·kg–1) > Suaeda spp. (8.10 g·kg–1) > I. cylindrica (6.15 g·kg–1) > P. australis
(5.80 g·kg–1). S. canadensis and Bare flat marshes had the highest carbon content, which is mainly
attributed to the presence of the most abundant carbon-fixation microbes, Fulvivirgaceae (family)
and Acidobacteria RB41 (genus), in the soil of these two plots. Both organic and dissolved organic
carbon contents at 10 cm were higher than those at the other two depths for all five marshes.

Conclusion:
The Bare flat exhibited strong carbon sequestration capability, second only to the invasive
S. canadensis plot among the five plots surveyed. It also showed the highest microbial abundance
and the greatest number of carbon-sequestration-related functional genes. The S. canadensis
plot exhibited the lowest microbial community diversity and abundance despite having the highest
carbon storage capacity. As an invasive species, S. canadensis should be removed to mitigate its
ecological impact.
Chlorogenic Acid Ameliorates CCl4-induced Liver Fibrosis by Modulating the
PI3K/AKT/mTOR Autophagy Pathway
Authors: Negm Amr , El-neanaey Amira A. , Khadr Abada El Sayed , Kamel Maher Abd El Naby , Abdo Ismail Abd El-Hamid , El Sayed Ibrahim El Tantawy , Darwish Wael Sobhy , Abd Eldaim Mabrouk Attia , Okaz Raghda Sobhy , Bahr Mohamed Hamdy , Almuraikhi Nihal , Beshara Nermine , Shawky Tamer M. , Mersal Ezat A. 
Published: January 2025

Background:
Liver fibrosis represents a serious risk to global health by impairing quality of life and
elevating the chances of hepatocellular carcinoma, while the intricate role of autophagy can either alleviate or
worsen fibrosis depending on its functioning.

Objective:
Herein, we aimed to investigate the therapeutic effect of chlorogenic acid in CCl4-induced hepatic
fibrosis and explore the autophagy pathway as the possible molecular target of chlorogenic acid.

Methods:
Rats were injected with carbon tetrachloride (1ml/kg) to induce liver fibrosis for 10 weeks. In the current study, the liver fibrosis rats were treated daily with chlorogenic acid (20, 40, and 60 mg/kg) for 30 days.
Liver function tests, renal function tests, lipid peroxidation, antioxidant enzyme, anti-inflammatory NF-κB level,
and autophagy pathway parameters (PI3K, AKT, mTOR, LC3, and Beclin-1) were assessed.

Results:
CCl4 elevated serum AST and ALT activity, and hepatic malondialdehyde, PI3K, AKT, and mTOR
expressions. It decreased LC3, Beclin-1 expression, and hepatic glutathione level. The results indicated that
chlorogenic acid treatment ameliorated the hepatic functions. It declined serum AST and ALT activities, improved hepatic GSH concentration, decreased lipid peroxidation, and downregulated PI3K, AKT, and mTOR
protein expressions in hepatic tissue. Moreover, chlorogenic acid increased the hepatic expression of LC3 and
Beclin-1. It also significantly decreased NF-kB expression.

Conclusion:
Chlorogenic acid showed promise in reducing liver damage in rats caused by CCl4 by influencing
the autophagy process and adjusting levels of antioxidant and inflammatory markers.
Effects of Citrus-derived Diosmetin on Melanoma: Induction of Apoptosis and
Autophagy Mediated by PI3K/Akt/mTOR Pathway Inhibition
Authors: Li jie , Xu Mingyuan , Wu Nanhui , Wu Fei , Chen Jiashe , Xu Xiaoxiang , Tan Fei , Liu Yeqiang 
Published: January 2025

Background:
Diosmetin (DIOS) is a naturally abundant flavonoid and possesses various biological
activities that hold promise as an anti-cancer agent. However, the anti-cancer activities and underlying mechanism of DIOS on cutaneous melanoma remain unclear.

Objective:
This study seeks to explore the anti-tumor effect and mechanism of DIOS in cutaneous melanoma.

Methods:
Here, a variety of in vitro and in vivo experiments, combined with RNA sequencing (RNA-seq), were
employed to ascertain the potential anti-cutaneous melanoma capacity and mechanism of DIOS.

Results:
The results demonstrated that DIOS considerably impeded cell proliferation and triggered cell apoptosis
in a dose- and time-dependent manner. Concurrently, DIOS markedly elevated the expression of pro-apoptotic
proteins (Cleaved caspase-3, Bax, Cleaved PARP, and Cleaved caspase-9) and downregulated the expression of
Bcl-2. Additionally, DIOS markedly upregulated the protein expressions of LC3B-II and Atg5, while downregulating p62 protein expression. Notably, pre-treatment with an autophagy inhibitor significantly inhibited DIOSinduced cell apoptosis and autophagy. Mechanistically, DIOS was identified to repress the PI3K/Akt/mTOR
signaling pathway by western blot analyses and RNA-seq. Finally, in vivo experiments using a syngeneic mouse
model confirmed the anti-tumor effect of DIOS, which exhibited high levels of apoptosis and autophagy.

Conclusion:
These findings propose that DIOS acts as a potential melanoma therapy that exerts its anti-tumor
effects by triggering apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway
The Trend of Prehospital Emergency Medical Care Services after the COVID-19 Pandemic: A Time Series Analysis
Authors: Karimifard Mousa , Hosseini Mahmood , Mahmudimanesh Marzieh , Jahanghiri Fereshteh , Mahmoodi Reza , Talebi Hadi , Soodejani Moslem Taheri 
Published: January 2025

Introduction
The COVID-19 epidemic in 2019 directly or indirectly had an impact on the healthcare system of hospitals. Iran was among the countries whose hospitals and especially the emergency system were affected by the outbreak of Coronavirus. The main objective of this study is to compare the number of emergency services, including heart and respiratory diseases, accidents, drowning, and CO poisoning, after the coronavirus pandemic in Chaharmahal and Bakhtiari provinces.

Methods
In this study, after obtaining the necessary permissions, an attempt was made to analyze the data on the most common Emergency Medical Services (EMS) extracted monthly by the city from the ASAYAR system during 2020-2023 using time series and Auto-regressive Integrated Moving Average (ARIMA) model.

Results
The number of emergency services related to accidents had an upward trend and was based on seasonal changes. Examination of seasonal effects shows that most emergency services occurred in the months of June through September; the number of emergency services related to heart disease was relatively constant. In addition, the number of emergency services related to respiratory diseases was constant on average despite many fluctuations in the observations. During the COVID-19 pandemic, the number of interventions and emergency calls increased.

Conclusion
Therefore, emergency services should increase their response capacity in these cases by modifying their programs and approaches, increasing response capacity and the number of staff, and providing appropriate training.
Pengaruh Promosi, Citra Merek, Dan Pengalaman Pelanggan Terhadap Niat Pembelian Kembali
Authors: Muharram Rizky Akbar , Puspaningrum Astrid 
Published: January 2025

Online travel agents are online-based travel agents that provide tourism products and services such as hotel reservation and public transportation ticket purchase. In Indonesia nowadays they are growing rapidly along with multiple types and competitors. PT Traveloka Indonesia is one of the key players in this business. The objective of this research is to analyze and explain the effects of promotion, Brand Image, and Customer Experience on airplane ticket repurchase intention through Traveloka in Malang City. The population of this explanatory research is people of Malang City who have the experience of purchasing airplane ticket through Traveloka. Using non-probability sampling method and purposive sampling technique, 140 people with the minimum age of seventeen years who have purchases airplane ticket through Traveloka at least once were selected as the sample. The results of the analysis using multiple linear regression indicate that promotion, Brand Image, and Customer Experience have positive and significant effects on repurchase intention.

Abstrak
Online Travel Agent adalah agen perjalanan berbasis online yang menyediakan produk dan layanan pariwisata, seperti reservasi hotel dan pembelian tiket transportasi publik. Saat ini, Online Travel Agent sedang berkembang secara pesat dengan pesaing yang banyak dan tipe yang beragam di Indonesia. PT. Traveloka Indonesia merupakan salah satu pemain kunci dalam bisnis ini. Penelitian ini bertujuan untuk menganalisis dan menjelaskan pengaruh Promotion, Brand Image, Customer Experience terhadap Repurchase Intention tiket pesawat Traveloka di Kota Malang. Jenis penelitian ini adalah explanatory research. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah non-probability sampling dengan menggunakan metode purposive sampling. Populasi dalam penelitian ini adalah masyarakat Kota Malang yang pernah membeli tiket pesawat melalui Traveloka dan diperoleh sampel sebanyak 140 responden dengan kriteria responden minimal berusia 17 tahun dan pernah membeli tiket pesawat melalui Traveloka minimal sebanyak satu kali. Penelitian ini menggunakan analisis linier berganda dan hasil penelitian ini menunjukkan bahwa Promotion, Brand Image, dan Customer Experience memiliki pengaruh positif dan signfikan terhadap Repurchase Intention.
THE EFFECT OF UNDERSTANDING THE CONCEPT OF PATRIOTISM AND LEARNING ENVIRONMENT OF MORALITY IN STUDENT LEARNING IN CIVIC EDUCATION IN SMK MUHAMMADIYAH 2 YOGYAKARTA
Authors: Veroza Risky , Samsuri Samsuri 
Published: January 2025

ABSTRACT This study aimed to describe Effect of Concept Training Patriotism against Morality Students at SMK Muhammadiyah 2 Yogyakarta, (2) whether there are Influence Learning Environment in Schools about the morality of students in SMK Muhammadiyah 2 Yogyakarta, and(3) whether there are simultaneously influence Patriotism Level concept Training and Learning Environment to Morality Students in Learning Citizenship Education at SMK Muhammadiyah 2 Yogyakarta. This research is a quantitative research. The instrument of this study using objective tests and questionnaires with interval measurement scale with Likert approach, if the data from this study using IBM SPSS program 21. The sample in this study is 10 x 3 variables studied (2 + 1 independent variable dependent variable) of the population. Data collection techniques of research using the technique of principal that comprehension tests and questionnaires, techniques of analysis in this study uses the classical assumption test consisting of test analysis of the distribution of the data, multicollinearity test, test Heteroskedesitas and Hypothesis Testing consists of Test The coefficient of determination (R2), Test F, and T test. The results showed that: (1) there is positive and significant level of understanding of the concept of patriotism against the morality of the students, the value of M statistics obtained t of 3.372 and p = 0.002. Because (3.372 2.051) and p 0.05, then H0 rejected and Ha accepted otherwise, (2) there is a positive and significant impact on the learning environment of the school to the student morality, values obtained t t statistic of 2.221 and p = 0.000. Because (2.221 2.051) and p 0.05, then H0 rejected and Ha accepted otherwise, and (3) there is a simultaneous effect between the level of understanding of the concept of patriotism and learning environment at school for morality SMK Muhammadiyah 2 Yogyakarta, the value of F statistic obtained Fhitung 18.407 and the value of p = 0.000. Because (16.724 3.385) and p 0.05, then H0 rejected and Ha accepted otherwise. Keywords. The Effect Of Understanding The Concept Of Patriotism, Learning Environment, Morality