bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the Emerging Niche Role of Extracellular Vesicles (EVs) in
Traumatic Brain Injury (TBI)
Authors: Ashique Sumel , Pal Radheshyam , Sharma Himanshu , Mishra Neeraj , Garg Ashish 
Published: February 2024

:
Extracellular vesicles or exosomes, often known as EVs, have acquired significant attention
in the investigations of traumatic brain injury (TBI) and have a distinct advantage in actively
researching the fundamental mechanisms underlying various clinical symptoms and diagnosing the
wide range of traumatic brain injury cases. The mesenchymal stem cells (MSCs) can produce and
release exosomes, which offer therapeutic benefits. Exosomes are tiny membranous vesicles produced
by various cellular entities originating from endosomes. Several studies have reported that
administering MSC-derived exosomes through intravenous infusions improves neurological recovery
and promotes neuroplasticity in rats with traumatic brain damage. The therapeutic advantages of
exosomes can be attributed to the microRNAs (miRNAs), which are small non-coding regulatory
RNAs that significantly impact the regulation of posttranscriptional genes. Exosome-based therapies,
which do not involve cells, have lately gained interest as a potential breakthrough in enhancing
neuroplasticity and accelerating neurological recovery for various brain injuries and neurodegenerative
diseases. This article explores the benefits and drawbacks of exosome treatment for traumatic
brain injury while emphasizing the latest advancements in this field with clinical significance.
Designing and Formulation of Nanocarriers for “Alzheimer’s and
Parkinson’s” Early Detection and Therapy
Authors: Abujamai Jakleen , Satar Rukhsana , Ansari Shakeel Ahmed 
Published: February 2024

Abstract:
The potential of nanotechnology in advancing the diagnosis and treatment of neurodegenerative
diseases is explored in this comprehensive literature review. The findings of these studies
suggest that nanotechnology has the capacity to improve existing therapeutic approaches, create
novel and safe compounds, and develop more precise imaging techniques and diagnostic methods
for neurodegenerative diseases. With the emergence of the nanomedicine era, a new and innovative
approach of diagnosing and treating these conditions has been introduced. Notably, the researchers'
development of a nanocarrier drug delivery tool demonstrates immense potential compared to
conventional therapy, as it maximizes therapeutic efficacy and minimizes undesirable as side
effects.
6-month Formulations of Androgen Deprivation Therapy for Advanced Prostate Cancer: Effectiveness and Rationale for Extended Dosing
Authors: Hafron Jason , Atkinson Stuart , Boldt-Houle Debbie , Renzulli Joseph F. 
Published: February 2024

Background:
Luteinizing hormone-releasing hormone (LHRH) agonists and GnRH antagonists are the most widely used androgen deprivation therapy to achieve castration levels of serum testosterone (T). Adherence to dosing schedules is important to avoid treatment failure. A recent analysis found a high non-adherence rate of 84% for LHRH agonist injections based on dosing schedules used in pivotal trials.

Method:
Narrative review of LHRH therapy and evaluation of which offers optimal efficacy, safety, and practicality.

Results:
6-month LHRH agonist formulations require fewer appointments for injections than shorter-acting formulations. Therefore, the frequency of late/missed doses and overall non-adherence may be reduced compared to options requiring frequent dosing (e.g., oral therapies and shorter-acting injections). This flexibility may be preferable for patients who live in multiple locations throughout the year, live long distances from clinics, and/or lack access to reliable transportation. 6-month formulations may also have cost benefits compared to shorter-acting doses. Despite similar levels of T suppression during the labeled dosing period, individual 6-month LHRH agonist formulations appear to have unique profiles, e.g., 6-month subcutaneous leuprolide acetate (LA) results in lower T escape rates compared to 6-month intramuscular LA, if dosing is late.

Conclusion:
The efficacy and practicality offered by 6-month LHRH formulations suggest these could reduce opportunities for late injections by requiring fewer office visits and provide greater confidence that efficacy will be maintained should there be extenuating circumstances leading to delays in therapy administration, as experienced during the recent pandemic.
Method of Effective Implementation of Intelligent Hardware Complexes in the Management of Passenger Transportation Processes within Urban Agglomerations
Authors: Safiullin Ravil , Tian Haotian 
Published: February 2024

Background:
The road transportation sector faces rising task complexity, driving the development of localized telematic traffic control systems. Integrating cutting-edge technologies is essential, surpassing administrative measures. A methodological approach is imperative for successful implementation.

Objective:
This study aimed to improve the efficiency of the implementation of intelligent information and communication technologies in the passenger transport system of urban agglomerations on the basis of objective assessment and rational choice of hardware complex in the field of vehicle traffic management.

Methods:
For the evaluation and effective implementation of intelligent hardware complexes in passenger transportation, diverse techniques, including mathematics and computer modelling, expert evaluations, theory of algorithms, computational experiment, mathematical statistics, observation, and measurement, were employed.

Results:
The approach of effective implementation of hardware complexes in passenger transportation management is proposed, and the order of calculation of passenger transport motion interval is developed. The calculations of economic and technical feasibility showed an increase of efficiency by 20-40% and a return on investment by 47%.

Conclusion:
The developed methodological approach for the effective implementation of intelligent hardware complexes in passenger transportation process control can serve as methodological support for the modernization of the automation and traffic control system of passenger transport. Further research will be aimed at automating the method by developing application software for the effective implementation of hardware technical control systems based on the described method. Additionally, this research can contribute to a broader study of complex systems, unraveling connections between parameters, information and technical aspects of hardware complexes and transportation and operational metrics in passenger transport processes.
Consumer Trust in Online Advertising - How Negative Perception Impacts
its Effectiveness
Authors: Nowacki Robert , Fandrejewska Alicja 
Published: February 2024

Background:
Building trust in a product, brand, or company is an important part of
forming a relationship between a company and consumers. One of the key factors influencing
consumer trust is two-way communication. Advertising, as a powerful communication tool capable of attracting attention and evoking emotions, plays a pivotal role in this process. Its characteristic feature is a dynamic increase in importance; in Poland, it currently holds the first place in
terms of advertising expenditures. Due to this growth, understanding the perception and effectiveness of online advertising becomes crucial in building trust with consumers.

Objective:
The study examines opinions concerning internet advertising and trust regarding its
content. It explores attitudes, evaluation, purchase motivation, actual purchases made under the
influence of online advertising, as well as consumers’ negative opinions about it.

Methods:
The discussion is based on a 2020 survey conducted among Polish internet users concerning the perception of online advertising and related negative associations. The survey included
402 respondents, selected using the CAWI method, with a quota sample differentiated by gender,
age, and place of residence.

Results:
Results: The results revealed relatively low trust and effectiveness levels regarding online advertising, with no variation based on respondents' demographic characteristics. Most respondents
(more than half of the respondents) indicated the excessive number of online advertisements, limited enthusiasm for advertisements, and low level of purchase incentive or actual motivation (rates
below 10%), and strongly agreed with negative statements about online advertising.

Conclusion:
The findings confirm the thesis of a general perception of online advertising as a
threat to conscious consumption.
Ocimum sanctum: The Journey from Sacred Herb to Functional Food
Authors: Kumari Sneha , Singh Preet Amol , Hazra Subhajit , Sindhwani Ritika , Singh Sukhvinder 
Published: February 2024

Abstract:
In recent years, the growing demand for herbal-based formulations, including functional
foods, has acquired significant attention. This study highlights historical, botanical, ecological,
and phytochemical descriptions and different extraction mechanisms of Ocimum sanctum
utilized in its processing. Besides this, it explores the utilization of Ocimum sanctum as a
functional food ingredient in various food products such as bakery products (biscuits, bread),
dairy products (herbal milk, cheese), and beverages (tea, juice, wine) while focusing on their
evaluation parameters, preparation techniques, and pharmacological activities. In terms of other
pharmacological properties, Ocimum sanctum-infused functional foods exhibited cognitiveenhancing
properties, adaptogenic qualities, anti-obesity effects, gastroprotective, antiinflammatory,
hypoglycemic, and immuno-modulatory effects. Thus, the diverse properties of
Ocimum sanctum offer exciting opportunities for the development of functional foods that can
promote specific health issues, so future research should focus on developing and analyzing novel
Ocimum sanctum-based functional foods to meet the growing demand of the functional food
industry.
Machine Learning–Based Prediction of Suicidality in Adolescents With Allergic Rhinitis: Derivation and Validation in 2 Independent Nationwide Cohorts
Authors: Lee Hojae , Cho Joong Ki , Park Jaeyu , Lee Hyeri , Fond Guillaume , Boyer Laurent , Kim Hyeon Jin , Park Seoyoung , Cho Wonyoung , Lee Hayeon , Lee Jinseok , Yon Dong Keon 
Published: February 2024

Background
Given the additional risk of suicide-related behaviors in adolescents with allergic rhinitis (AR), it is important to use the growing field of machine learning (ML) to evaluate this risk.

Objective
This study aims to evaluate the validity and usefulness of an ML model for predicting suicide risk in patients with AR.

Methods
We used data from 2 independent survey studies, Korea Youth Risk Behavior Web-based Survey (KYRBS; n=299,468) for the original data set and Korea National Health and Nutrition Examination Survey (KNHANES; n=833) for the external validation data set, to predict suicide risks of AR in adolescents aged 13 to 18 years, with 3.45% (10,341/299,468) and 1.4% (12/833) of the patients attempting suicide in the KYRBS and KNHANES studies, respectively. The outcome of interest was the suicide attempt risks. We selected various ML-based models with hyperparameter tuning in the discovery and performed an area under the receiver operating characteristic curve (AUROC) analysis in the train, test, and external validation data.

Results
The study data set included 299,468 (KYRBS; original data set) and 833 (KNHANES; external validation data set) patients with AR recruited between 2005 and 2022. The best-performing ML model was the random forest model with a mean AUROC of 84.12% (95% CI 83.98%-84.27%) in the original data set. Applying this result to the external validation data set revealed the best performance among the models, with an AUROC of 89.87% (sensitivity 83.33%, specificity 82.58%, accuracy 82.59%, and balanced accuracy 82.96%). While looking at feature importance, the 5 most important features in predicting suicide attempts in adolescent patients with AR are depression, stress status, academic achievement, age, and alcohol consumption.

Conclusions
This study emphasizes the potential of ML models in predicting suicide risks in patients with AR, encouraging further application of these models in other conditions to enhance adolescent health and decrease suicide rates.
Aspects of geopolitical and geo-economic choice of Eastern Siberia – Pacific Ocean
Authors: Сериков Павел Юрьевич 
Published: February 2024

В статье показано становление, реализация и развитие отечественного мегапроекта «Трубопроводная система Восточная Сибирь – Тихий океан» (ВСТО). Представлены неизвестные научной общественности подробности, связанные со становлением проекта и с трудным выбором в его пользу, который происходил в условиях острого соперничества, затрагивавшего сферы геополитики, экономики и экологии. Рассмотрены острые вопросы, связанные с оценкой эффективности проекта и обеспечением экологической безопасности в ходе его реализации. Показаны множественные изменения, которые ВСТО, как долгосрочный проект, претерпел на различных стадиях развития. Отмечается, что сегодня ВСТО представляет собой сложноорганизованную комплексную систему, являющуюся важнейшим компонентом национальной экономики, развивающуюся в соответствии с уникальной спецификой, обладающую своими структурными особенностями и сетевой тарифной философией.
This article explores the establishment, implementation, and development of the Eastern Siberia – Pacific Ocean (ESPO) pipeline system, which is a significant national megaproject. It provides previously undisclosed information about the project's formation and the challenging decision-making process it underwent before the difficult choice was made in its favor amidst intense competition in the realms of geopolitics, economics, and ecology. The article addresses sensitive issues concerning the project's effectiveness and the measures taken to ensure environmental safety during its implementation. It highlights the numerous changes that ESPO, as a long-term project, has undergone at different stages of its development. It is noted that today ESPO stands as a large and complex system, playing a critical role in the national economy. It develops according to its own rules and possesses its own structural characteristics and network tariff philosophy.
PRODUKTIVITAS ALAT TANGKAP PURSE SEINE PADA RUMPON PORTABLE DI PERAIRAN KARANG JERUK, TEGAL
Authors: Yusfiandayani Roza , Imron Mohammad , Mawardi Wazir , Baskoro Mulyono S. , Raihan Muhamad Reza , Rahmad Adrul , Aziz Ravy Nur , Wahdati Fajriyah Cahyani 
Published: February 2024

Tegal merupakan salah satu Kabupaten di Jawa Tengah yang memiliki kekayaan sumber daya perikanan cukup besar. Perairan Karang Jeruk merupakan salah satu perairan yang cukup strategis dalam pengembangan perikanan tangkap di Kabupaten Tegal, karena perairan ini berbatasan langsung dengan Laut Jawa sehingga memiliki potensi sumber daya ikan yang cukup melimpah. Penggunaan alat bantu rumpon portable diharapkan dapat meningkatkan hasi tangkapan nelayan sehingga memberikan solusi terhadap permasalahan penurunan hasil tangkapan yang dialami oleh nelayan purse seine perairan Karang Jeruk, Tegal. Tujuan dari penelitian ini adalah untuk mengetahui komposisi hasil tangkapan dan menghitung produktivitas tangkapan purse seine pada rumpon portable. Metode penelitian dilakukan dengan metode experimental fishing. Data hasil tangkapan dianalisis secara deskriptif untuk mengidentifikasi komposisi jenis hasil tangkapan dan jumlah masing-masing spesies ikan yang tertangkap. Produktivitas tangkapan didapatkan dengan cara membandingkan jumlah hasil tangkapan dengan lama waktu operasi penangkapan. Hasil penelitian menunjukkan bahwa ikan tangkapan utama purse seine terdiri dari ikan selar bentong, ikan tembang, ikan teri gelagah, ikan tongkol, dan cumi-cumi. Komposisi jenis ikan hasil tangkapan merupakan indikasi keberadaan ikan di daerah tersebut, dimana operasi penangkapan dengan purse seine dilakukan. Nilai produktivitas tangkapan memiliki nilai rata-rata 900,8 kg/setting.
Kata kunci: Karang Jeruk, produktivitas, purse seine, rumpon portable, Tegal
A PERIKANAN PUKAT UDANG DI KABUPATEN MUKOMUKO YANG BERBASIS DI PANGKALAN PENDARATAN IKAN PASAR BANTAL
Authors: Erizal Arief , Wiyono Eko Sri , Zulkarnain  , Taurusman Am Azbas 
Published: February 2024

Pukat udang di perairan Mukomuko mulai digunakan sejak tahun 1980-an. Sejak saat itu nelayan biasa menggunakan alat tangkap tersebut untuk menangkap udang. Tujuan penelitian ini untuk mendeskripsikan unit penangkapan dan daerah penangkapan udang di Kabupaten Mukomuko yang berbasis Pangkalan Pendaratan Ikan (PPI) Pasar Bantal. Metode penelitian yang dilakukan adalah observasi dan wawancara dengan nelayan. Materi penelitian meliputi kapal penangkapan, metode pengoperasian alat tangkap, perlengkapan penangkapan, daerah penangkapan dan jenis udang target tangkapan, serta non targetnya. Hasil penelitian menunjukkan bahwa kapal yang digunakan oleh nelayan penangkap udang di perairan Mukomuko yaitu kapal motor berukuran 6 GT dengan menggunakan mesin diesel berukuran 30 PK yang diletakkan di bagian inboard kapal. Ukuran kapal yang digunakan oleh nelayan penangkap udang yaitu dengan panjang 10 meter, lebar 2,5 meter dan tinggi 1,1 meter. Kontruksi pukat udang terdiri dari ikatan tali kantong, kantong, badan, sayap, tali ris atas, tali ris bawah, pelampung, pemberat, besi, rantai, papan pembuka dan tali penarik. Adapaun proses pengoperasiannya terdiri dari setting, towing dan hauling. Hasil tangkapan utamanya yaitu udang jerbung (Penaeus merguiensis), udang krosok (Parapenaeopsis sp), udang dogol (Metapenaeus ensis), dan udang jambu (Metapenaeus dobsoni), di samping banyaknya bycatch dan tangkapan yang dibuang (discarded). Perlu upaya pengendalian alat tangkap pukat udang agar tidak mengancam keberlanjutan sumberdaya udang di lokasi ini
Kata Kunci: Kabupaten Mukomuko, perikanan udang, PPI Pasar Bantal, pukat udang.
Review of Robert Cogan, New Images of Musical Sound (Harvard University Press, 1984)
Authors: Smoliar Stephen 
Published: February 2024

While Robert Cogan’s New Images of Musical Sound is
now over ten years old, the applicability of Fourier analysis as a
basis for music theory is still a relevant issue. This review
attempts to put Cogan’s work into both a technical perspective,
regarding what sound analysis technology now supports, and a
theoretical one, regarding his attempt to build a theory on the
foundations of phonology. From a technical point of view, it is
now far easier to approach analysis as Cogan has done; but his
attempt to build a theory suffers from some significant.
Review of Mark Lindley’s and Ronald Turner-Smith’s Mathematical Models of Musical Scales: A New Approach (Verlag fuer systematische Musikwissenschaft, 1993)
Authors: Cuciurean John 
Published: February 2024

In Mathematical Models of Musical Scales,
Mark Lindley and Ronald Turner-Smith attempt to model scales
by rejecting traditional Pythagorean ideas and applying
modern algebraic techniques of group theory. In a recent
MTO collaboration, the same authors summarize their work
with less emphasis on the mathematical apparatus. This review
complements that article, discussing sections of the book
the article ignores and examining unique aspects of their
models.
Contemporary Music Theory and the New Musicology
Authors: McCreless Patrick 
Published: February 2024

Continuing tensions between contemporary music theory and
the new musicology suggest the need for music theorists to step back
and look at their discipline in terms of the fresh perspective that
the new musicology offers—a task that the following essays by Scott
Burnham, Marion Guck, Matthew Brown, Joseph Dubiel, and Kofi Agawu
undertake. The introduction provides an intellectual context for the
essays by reflecting on the short history of modern American music
theory, beginning around 1960, and by reading the relationship of
contemporary theory and the new musicology in terms of Michel
Foucault’ss work on power and knowledge.
The Deconstruction of Musicology
Authors: Walker Jonathan 
Published: February 2024

This essay is a critical examination of the claims of
deconstruction and “textuality.” The three sections of the argument
concern: I. Derrida, in one of his most frequently cited deconstructions;
II. the problems of Saussurean semantics and post-structuralist textuality;
III. broadly deconstructive strategies to be found in musicological
writings.
Report from the Three Seminars on Contemporary Music with Connection to the ISCM World Music Days in Copenhagen, 1996
Authors: Broman Per F. 
Published: February 2024

University of Copenhagen, Department of
Musicology hosted a three-day series of lectures in
conjunction with the ISCM World Music Days in Copenhagen
1996. The unifying thread running through all seminars was
institutionalization of the avant-garde and the concept of
pluralism. Of particular interest from a theoretical
perspective was the presentation of Norwegian young scholar
Erling Gulbrandsen’s recent doctoral dissertation on
Boulez’s Pli selon Pli.
Handel, the Sarabande, and Levels of Genre
Authors: Willner Channan 
Published: February 2024

In his commentary on my article, “More on Handel and the
Hemiola,” David Schulenberg favors a historically informed,
intertextual approach to the analysis of relatively unfamiliar works,
one that hinges on the listener’s knowledge of generically comparable
works. By way of reply I combine recent semiotic theory with a more
traditional Schenkerian approach to show how the narrative
articulation of generic topics shapes the way we hear, interpret, and
re-create such works, and how such articulation responds to tensions
that are inherent in stylistic and generic norms.
Music Theory at the Amsterdam School of Music
Authors: Douw Andre M. , Schuijer Michiel C. 
Published: February 2024

The theory curricula offered by the classical music departments of the
former Sweelinck and Hilversum Conservatories represented two distinct trends in Dutch
music theory teaching. While the Sweelinck Conservatory’s courses reflected a
pragmatic view of the discipline, and laid much emphasis on harmony and ear-training,
those in Hilversum were more intellectually oriented, focusing attention on music analysis.
After these two strongly different institutes decided to merge to form the Amsterdam School
of Music, an entirely new theory curriculum had to be devised. Electives became a distinctive
feature of the new curriculum. Paragraphs 1–7 of this article deal with the historical aspects
of the merger, while in paragraphs 8–12 the new curriculum is described.
Review of Ethan Haimo, “Atonality Analysis, and the Intentional Fallacy,” Music Theory Spectrum (18/2), 167-199
Authors: Latham Edward D. 
Published: February 2024

Ethan Haimo’s article, “Atonality, Analysis
and the Intentional Fallacy,” provokes thought on three
issues: 1) the issue of conscious vs. unconscious
intentions; 2) the issue of documentary evidence and its
uncritical acceptance; and 3) the evolution of pitch-class
set theory in the last twenty-five years. The present author
addresses these three issues and challenges Haimo’s conclusion
that analyses that do not take intentions into account
effectively replace the composer with the theorist as an
authority figure.
Chopin, Pygmies, and Tempo Fugue
Authors: Taylor Stephen A. 
Published: February 2024

One of the goals of Gyorgy Ligeti’s ongoing series of piano
etudes (fifteen at last count) is to produce exceedingly complex
polyrhythms—or, as he says, “illusory rhythms”—with a single, human
interpreter. Among the most striking is number six, “Automne a
Varsovie” (1985), which combines disparate influences, including
19th-century piano music and sub-Saharan African polyrhythm, to
produce an effect which Ligeti has called “tempo fugue.” To see how
Ligeti’s fugue works, this article examines his various influences,
then analyzes the piece itself.