bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical effectiveness of a self-management intervention for patients with Persistent Depressive Disorder and their partners/caregivers: results from a multicenter, pragmatic randomized controlled trial.
Authors: Solis Ericka , Carlier Ingrid , Kamminga Noelle , Giltay Erik , Hemert Albert M. Van 
Published: October 2023

Abstract
Background: Persistent depressive disorder (PDD) is prevalent and debilitating. For patients with PDD, psychiatric rehabilitation using self-management interventions is advised as the next therapeutic step after multiple unsuccessful treatment attempts. The “Patient and Partner Education Program for All Chronic Diseases” (PPEP4All) is a brief, structured selfmanagement program that focuses on functional recovery for patients and their partners/caregivers. In chronic somatic disorder populations, PPEP4All has already been shown to be clinically effective. We examined whether PPEP4All adapted for PDD (PPEP4All-PDD, 9 weekly group or individual sessions) is also clinically effective for adults/elderly with PDD and their partners/caregivers compared to care-as-usual (CAU) in specialized mental healthcare.
Methods: In this mixed-method multicenter pragmatic randomized controlled trial, 70 patients with PDD and 14 partners/caregivers were allocated to either PPEP4All-PDD (patients, n = 37; partners/caregivers, n = 14) or CAU (patients, n = 33; partners/caregivers, not included) and completed questionnaires at 0, 3, 6, and 12 months regarding depressive symptoms, psychopathology, psychosocial burden, mental resilience, and happiness/wellbeing. Qualitative data were collected regarding treatment satisfaction. Data were analyzed using mixed model analyses and an intention-to-treat (ITT) approach.
Results: There was no statistically significant difference in any outcome regarding clinical effectiveness between PPEP4All-PDD and CAU. Subgroup analysis for depressive symptoms did not show any interaction effect for any subgroup. Although 78% of participants recommended PPEP4All-PDD, there was no difference in treatment satisfaction between PPEP4All-PDD (score = 6.6; SD = 1.7) and CAU (score = 7.6; SD = 1.2), p = 0.06.
Conclusion: Although depressive symptoms did not improve relative to CAU, this only confirmed that treatment for patients with treatment-resistant PDD should move from symptom reduction to functional recovery. Also, functional recovery may be reflected in other outcomes than psychosocial burden, such as self-empowerment, in patients with treatment-resistant PDD. Future research on PPEP4All-PDD could focus on a longer-term program and/or online program that may also be offered earlier in the treatment process as an empowerment intervention.
Trial Registration: Netherlands Trial Register Identifier NL5818. Registered on 20 July 2016, https://clinicaltrialregister.nl/nl/trial/20302
Strain Engineering of Nonlinear Nanoresonators from Hardening to Softening
Authors: Alijani Farbod , Li Zichao , Xu Minxing , Norte Richard , Aragón Alejandro , Steeneken Peter 
Published: October 2023

Abstract
Although strain engineering and soft-clamping techniques for attaining high Q-factors in nanoresonators have received much attention, their impact on nonlinear dynamics is not fully understood. In this study, we show that nonlinearity of high-Q Si3N4 nanomechanical string resonators can be substantially tuned by support design. Through careful engineering of support geometries, we control both stress and mechanical nonlinearities, effectively tuning nonlinear stiffness over a factor more than 100. Our approach also allows control over the sign of the Duffing constant, turning it negative via buckling, and resulting in nonlinear softening of the mechanical mode that conventionally only exhibits hardening behavior. We elucidate the influence of support design on the magnitude and trend of the nonlinearity using both analytical and finite element-based reduced-order models that accurately validate our experimental findings. Our work not only provides the first evidence of the role of soft-clamping on the nonlinear dynamic response of nanoresonators, but it also offers new possibilities for nullifying or enhancing nonlinearity in a highly reproducible and fully passive manner, appealing to both classical and quantum-limited resonant sensors.
Engineering surface dipoles on mixed conducting oxides with ultra-thin oxide decoration layers
Authors: Siebenhofer Matthaeus , Nenning Andreas , Rameshan Christoph , Blaha Peter , Fleig Juergen , Kubicek Markus 
Published: October 2023

Abstract
Improving materials for energy conversion and storage devices is deeply connected with an optimization of the surfaces of these materials. Surface modification has therefore emerged as a very promising strategy on the way to enhance modern energy technologies. This study shows that surface modification with ultra-thin oxide layers allows for a systematic tailoring of surface properties, in particular of the surface dipole and the work function, and it introduces the ionic potential of surface cations as a readily accessible descriptor for these effects. The combination of X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) illustrates that basic oxides with a lower ionic potential than the host material induce a positive surface charge and reduce the work function of a mixed conducting host material and vice versa. The emerging surface dipoles are caused by changes in the energy landscape, leading to redistribution of electronic charge density and/or a geometric reorientation of the surface. As a proof of concept that this strategy is widely applicable to tailor surface properties, we examined the effect of ultra-thin decoration layers on the oxygen exchange kinetics of pristine thin films of structurally and chemically different mixed conducting oxides in very clean conditions by means of in-situ impedance spectroscopy during pulsed laser deposition (i-PLD). The extended study confirms that basic decorations with a reduced surface work function lead to a substantial acceleration of the oxygen exchange on a material's surface. Computational results suggest that the underlying mechanism of the kinetic improvement relies on a modification of the energetics of charged O2 adsorbates and substantiate their importance for the oxygen exchange reaction.
HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia
Authors: Yan Wei , Jing Mengjia , Xiong Xiaofeng , Mao Xin , Song Qianben , Zhang Lumiao , Ouyang Yiming , Pang Yingzhi , Fu Yu 
Published: October 2023

Abstract
Background
Mitochondrial transfer has been found to play an important role in various diseases, and many mitochondrial biological behaviors can be regulated by HMGB1. However, the role of mitochondrial transfer in HCC and its relationship with HMGB1 are currently unknown.
Method
Field emission scanning electron microscope, immunofluorescence, and cell flow cytometry were used to detect mitochondrial transfer between HCC cells. Analyze the change and significance of related molecules in clinical samples of HCC through bioinformatics analysis and tissue microarrays. The specific mechanism was determined by co-immunoprecipitation, luciferase reporter assay and chromatin immunoprecipitation. Cell metastasis and invasion ability were detected through in vitro cell migration and invasion analysis, as well as in vivo tail vein lung metastasis in mice.
Result
We confirmed the transfer of mitochondria between HCC cells through tunnel nanotubes. The transfer of mitochondria from the higher invasive HCC cells to the lower invasive HCC cells could enhance the migration and invasion ability of the latter, and the hypoxic conditions increased the mitochondria transfer between HCC cells. During this process, RHOT1, as the mitochondrial transport protein, promoted mitochondrial transfer and promoted the migration and metastasis of HCC cells. Under hypoxia, HMGB1 further regulated the expression of RHOT1 by increasing the expression of NFYA and NFYC subunits in the NF-Y complex. RAC1, as the protein associated with the formation of tunnel nanotubes, promoted mitochondrial transfer and also promoted the development of HCC. Besides, HMGB1 regulated RAC1 aggregation to the cell membrane under hypoxia. In clinical samples, patients with high expression of HMGB1, RHOT1, or RAC1 in HCC had the relatively shorter overall survival period.
Conclusion
Under hypoxic conditions, HMGB1 promotes mitochondrial transfer and migration and invasion of HCC cells by increasing the expression of mitochondrial transport protein RHOT1, as well as the expression of tunnel nanotube formation related protein RAC1.
Comparison of the obturator nerve block performed blinded according to the anatomical signs and ultrasound-guided obturator nerve block in patients undergoing transurethral resection: randomized controlled trial
Authors: Yasar Eylem , Uysal Ali İhsan , Akarken İlker , Altıparmak Başak , Demirbilek Semra Gumus 
Published: October 2023

Abstract
BACKGROUNDː It has been reported that obturator nerve block application before transurethral resection operation in bladder lateral wall tumors provides a safer surgical field and reduces tumor recurrence and complete resection of the tumor. Due to the different anatomical structure of the obturator nerve, obturator nerve block (ONB) can be performed with different methods.
METHODSː A total of 122 patients, 22 females with a mean age of 56.63 ± 12.99 and 100 males with a mean age of 63.18 ± 8.00, were included in our study. ONB was performed under ultrasound guidance by the same anesthesiologist in the first group, and ONB was performed according to anatomical signs blindly in the second group by the same urology doctor.
RESULTSːIn group 1, in 53 cases it was observed with Absence of Spasm, and in 5 cases Spasm was present. On the other hand, in group 2, in 49 cases Spasm was absent, whereas, in 15 cases spasm was present.
CONCLUSIONSː As a conclusion there was a significant relationship between groups on spasm.
Correlation analysis of time-interval parameter of ductus venosus and neonatal blood pressure at birth in fetal growth restriction
Authors: Yoshida Tomohiro , Kurihara Yasushi , Yokoi Natsuko , Kitada Kohei , Nakagawa Kayoko , Tahara Mie , Hamuro Akihiro , Nakano Akemi , Misugi Takuya , Tachibana Daisuke 
Published: October 2023

Abstract
The aims of this study were to compare the blood pressure at birth between fetal growth restriction (FGR) cases and normally grown preterm cases, and also to elucidate whether the time interval of the flow velocity waveform of ductus venosus (DV-FVW) and/or the pulsatility index of ductus venosus (DV-PI) shows a correlation with blood pressure at birth in FGR cases. FGR was defined as an estimated fetal body weight below -2.0 SD with an elevated PI of the umbilical artery (> 95 percentile). As a control group (CTL), infants matched for gestational week of delivery were selected. Doppler parameters (DV-PI and the ratio of systolic to diastolic time intervals of the DV-FVW (DV-S/D)) were measured in the FGR group within a day before delivery. The relationships were assessed between Doppler parameters and neonatal blood pressures: systolic, diastolic, and mean arterial pressure. Each blood pressure in the FGR group was lower than those in the control group. Moreover, there were significant correlations of the DV-S/D with systolic, diastolic and mean arterial pressures in the FGR group, while the DV-PI did not show any correlation with any blood pressures. The DV-S/D might be a predictive parameter for low blood pressure at birth in preterm neonates complicated with placental dysfunction.
Analyzing The Construct Validity of the Indonesian Basic Empathy Scale using the Rasch model
Authors: Diswantika Noviana , Suherman Uman , Rusmana Nandang , Suryana Dodi , Qurbi Abdullah , Noor Amelia Mohd 
Published: October 2023

Abstract
Background The COVID-19 pandemic has brought many changes to human social life. The ability for empathy plays an essential role in these changes because empathy enables the process of sharing experiences, needs, and desires between individuals. In this study, the author aims to evaluate, develop and modify the Basic Empathy Scale in Adults (BES-A) to adapt it to Indonesian culture, which will be transformed into Indonesian Basic Empathy Scale (I-BES).
Methods The methodology used in this research is a survey design. Research using a survey design, the participants, Indonesia (n= 101, male 17, female 84 regions 5 region), evaluation was done by analyzing the Indonesian Empathy Scale using the RASCH model.
ResultsShow that the instrument does not have unidimensionality. Based on the results of fitting the item model, several items on the I-BES were omitted because they were deemed inappropriate, including at least five items. The instrument has good dispersion reliability among items but low dispersion reliability among individuals. The Indonesian Basic Empathy Scale needs further improvement to obtain response categories based on its functions.
ConclusionThis study can be used as teaching material for counseling and guidance groups, and the personality theory of sharpening the material regarding the development of empathy, in addition to the measurement instruments for the development of empathy, which can be used as material for counseling and guidance assessment courses.
Electrochemical Properties of Electrospun Metal-Organic Frameworks (MOFs) Nanofibers as Novel Hybrid Electrode Materials
Authors: Sarkar Subhajit , Salleh Noordini Mohamad , Eroğlu Özay , Kuru Fatma , Özen Afike Ayça , Aslan Sema , Subasat Hulya Kara , Halim Siti Nadiah Abdul 
Published: October 2023

Abstract
This research focuses on exploring the electrochemical properties of UiO-66 and MOF-199 (metal-organic framework (MOFs)-based electrodes, in the form of nanofibers fabricated along with PVDF through electrospinning techniques on a pencil graphite electrode (PGE). SEM images obtained showed the UiO66/PVDF and MOF199/PVDF nanofibers have different morphology affected by addition of different MOF into the PVDF polymers with mean diameters of 750 nm and 750 nm respectively. TGA results indicated that the nanofibers possess a high thermal degradation temperature, exceeding 400°C, which indicates increased material robustness compared to the pure MOFs alone. Mechanical strength analysis of the nanofibers revealed contrasting mechanical properties. UiO66/PVDF exhibited a strain percentage of 309.4 but a relatively low stress value of 0.4299 MPa. On the other hand, MOF199/PVDF displayed a high stress value of 3.718 MPa but a lower strain percentage of 46.34%. Electrochemical studies were conducted on the electrodes; MOFs/PVDF/PGE and the MOFs/GCPE (carbon paste electrodes) to compare MOFs’ standalone electrochemical properties. Different scan rates were applied to all electrodes in the interval of 5, 20, 50 100, and 250 mVsec-1 and the best Cs values were obtained from the MOF199/PVDF/PGE nanofiber electrode. Furthermore, prolonged charge-discharge measurements were executed using a scan rate of 100 mV/sec across 200 cycles for all electrodes. This phase was extended to 3000 cycles exclusively for the MOF199/PVDF/PGE nanofiber electrode. The outcomes underscored remarkable stability, particularly notable in the case of the MOF199/PVDF/PGE nanofiber electrode, highlighting its potential as a reliable energy storage electrode.
Sadness influences brightness, amazement favours curvilinearity, tenderness sets the shades of green: how musical emotions shape image making
Authors: Cenerini Costanza , Vollero Luca , Stefano Nicola Di , Santonico Marco , Pennazza Giorgio , Keller Flavio 
Published: October 2023

Abstract

In the growing literature on audiovisual correspondences, the question of how music influences image making has receivedlittle attention. To fill this gap, in this study we investigated the effect of music-induced emotions on several key parameters thatdefine drawing. Hypothesising that drawing while listening to emotionally evocative music would result in emotionally coherentartwork, we designed a two-phase experiment to test this hypothesis. In the first phase, participants listened to ten originalsongs and were asked to create an image by changing various parameters (e.g., hue, shape, dimension). They were alsoasked to describe the emotional response elicited by the auditory stimuli by giving a score to a set of 9 musical emotions(amazement, solemnity, tenderness, nostalgia, calmness, power, joyful activation, tension, and sadness). In the second phase,participants were shown images in which one of the image parameter was set at a extreme value and the others were moderate,and asked to describe the emotions elicited by the images. This approach allowed us to gain data on the association betweenmusic and images, music and emotions, and images and emotions, and therefor assess whether paired audiovisual contentsare associated with the same emotional meaning. Findings reveal that auditory sadness correlates with visual brightnessand with the spatial dispersion of visual objects. Sadness also influences the saturation of light. Amazement shared manysimilarities with sadness in terms of influenced parameters, namely brightness and dispersion, and was correlated with thecolour green, typically evoking solemnity and tenderness. This study sheds novel light on the role of emotions in the mediationof auditory-visual associations.
Clinical Significance and Potential Molecular Mechanisms of Angiotensin-Converting Enzyme 2 in Colorectal Cancer
Authors: Zeng Da-Tong , Wen Jia-Ying , Fang Ye-Ying , Wei Dan-Ming , Chen Gang , Shi Lin , Huang Wei-Jian 
Published: October 2023

Abstract
Background
Angiotensin-converting enzyme 2 (ACE2) has emerged as a focal point in cancer research due to its potential protective role in cancer progression, generating significant interest because of its negative correlation with oncogenic pathways and positive association with antitumor immune responses in various cancers.
Objective
The role of ACE2 in colorectal cancer (CRC) remains poorly understood, meriting further investigation.
Methods
This study employed mRNA and protein analyses to comprehensively examine ACE2 expression in CRC tissues. An internal sample validation and the integration of data from 3,101 samples collected across multiple research centers support our findings. We evaluated ACE2’s ability to distinguish between CRC and non-CRC cases using the area under the receiver operating characteristic curve (AUC). Additionally, we explored the associations of ACE2 protein expression with CRC pathologic type and PDL1 positivity and investigated potential mechanisms involving antiangiogenesis and immune response.
Results
Our study found a significant upregulation of ACE2 mRNA and protein expression in CRC tissues, which was substantiated by internal validation and data integration. ACE2 exhibited strong discriminatory capacity, with an AUC of 0.844, effectively distinguishing CRC from non-CRC cases. Furthermore, ACE2 protein expression closely correlated with CRC pathologic type and PDL1 positivity among patients. The implicated mechanisms include antiangiogenesis and immune response.
Conclusion
The protein expression of ACE2 shows a close correlation with pathologic type and PDL1 positivity among patients with CRC. The underlying molecular mechanisms of ACE2 may be related to antiangiogenesis and immune response.
Efficacy and safety of transrectal natural orifice specimen extraction compared with conventional laparoscopy surgery for selected patients with colorectal cancer: a propensity score matching analysis and literature review
Authors: Chan Li‐Yang , Chern Yih-Jong , Hsu Yu-Jen , Jong Bor-Kang , Tsai Wen-Sy , Hsieh Pao-Shiu , Liao Chun-Kai , You Jeng-Fu 
Published: October 2023

Abstract
Purpose
Conventional laparoscopy (CL) surgery requires mini-laparotomy to extract the pathological specimen. However, by using a natural orifice as the delivery route, natural orifice specimen extraction (NOSE) surgery avoids a large incision. This study analyzed the safety and efficacy of NOSE compared with CL surgery for colorectal cancer.
Methods
We conducted a retrospective analysis of 1,189 patients who underwent surgery for primary colorectal cancer between the cecum and upper rectum. Propensity score analyses were applied to the NOSE and CL groups in a 1:1 matched cohort.
Results
Compared with the CL group, the NOSE group experienced a shorter time to first flatus (1.6 ± 0.8 vs. 2.0 ± 1.2 days, p < 0.001), first stool (2.7 ± 1.5 vs. 4.1 ± 1.9, p < 0.001), liquid diet (2.3 ± 1.3 vs. 3.6 ± 1.8 days, p < 0.001), soft diet (3.9 ± 2.0 vs. 5.2 ± 1.9 days, p < 0.001) and a shorter hospital stay (5.1 ± 3.5 vs. 7.4 ± 4.8 days, p < 0.001). The NOSE group exhibited lower mean pain intensity and lower highest pain intensity on postoperative days 1, 2, and 3.
Conclusion
NOSE resulted in reduced time to oral intake, less postoperative pain, and a shorter hospital stay. We proposed a transrectal NOSE technique for right-sided colon cancer and left-sided colon cancer near the splenic flexure with comparable short-term outcomes. With this approach, we hope to expand the application of NOSE to colon cancer surgery irrespective of tumor location or patient sex.
A cross-sectional questionnaire-based landscaping of female infertility reveals genital Infections as a major contributor to reproductive tract anomalies, menstrual disorders, and infertility
Authors: PATNAIK NARESH , Sarkar Uttam , Jojula Malathi , Vaddiraju Hema , Dey Ruchi Jain 
Published: October 2023

Abstract
Purpose
Female infertility is a global health concern. The association of genital infections with female infertility is neglected due to their chronic but asymptomatic nature. Lack of routine diagnosis and delay in treatment further causes intractable pathological sequalae and consequential infertility. This study aims to identify the most significant prognostic symptoms of genital infection(s) that correlate strongly with reproductive tract anomalies, menstrual disorders, and infertility.
Methods
We designed a detailed questionnaire and conducted a cross-sectional study with 100 female subjects, categorized into infertile (n1 = 62) and healthy groups (n2 = 38). The data collected was documented and statistically analysed.
Results
This study highlights an early onset of infertility (21–30 years). Almost 27% of the infertile female subjects are symptomatic for genital infections and ~ 42% exhibit menstrual irregularities. Polycystic ovarian syndrome/disease (PCOS/PCOD, ~ 30%), are observed to be the most predominant disorders followed by endometrial disorders (~ 10%) and tubal damage (~ 8%) in infertile subjects. A multivariate correlation analysis revealed a highly significant (p ≤ 0.05) and strong association (0.15 < Φ ≤ 1.0) between menstrual disorders, endometrial disorders, uterine/tubal blockage, and hormonal disruption with infection-associated symptoms, such as vaginitis, cervicitis, pelvic inflammatory disorder (PID), dyspareunia, tuberculosis (TB), urinary tract infection (UTI).
Conclusions
Our study reveals genital infections to be a significant contributor to female infertility. The questionnaire designed here offers a useful tool for self or clinical assessment and may help in timely prognosis/diagnosis of genital infections which may contribute to improved management of reproductive health and fertility.