bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capsular phimosis with intraocular lens tilt and decentration
Authors: Chee Soon-Phaik , Dick H. Burkhard , Masket Samuel , Beltz Jacqueline , Vajpayee Rasik B. , Yeu Elizabeth , Zhu Dagny 
Published: September 2023

A 34-year-old woman with quiescent bilateral intermediate uveitis maintained on once-daily dexamethasone 0.1% eyedrops, complicated by left cataract and glaucoma controlled with a single antiglaucoma medication, presented for cataract surgery. Her left corrected distance visual acuity (CDVA) was 20/40 because of a posterior subcapsular lens opacity. The anterior chamber angles appeared closed in all 4 quadrants on gonioscopy. Ultrasound biomicroscopy (UBM) confirmed the gonioscopy findings and, in addition, revealed a crystalline lens thickness of 5.53 mm, normal ciliary body structure, and multiple localized chorioretinal scars with membranes over the pars plana region. She underwent left phacoemulsification, goniosynechiolysis, and in-the-bag implantation of a single-piece monofocal hydrophobic acrylic intraocular lens (IOL).
On the first postoperative day, she achieved pinhole vision of 20/70 (−6 diopters [D] myopia to balance with the fellow eye). There was mild anterior chamber cellular activity and flare, consistent with postoperative inflammation. Her intraocular pressure (IOP) was 16 mm Hg without antiglaucoma therapy. She was advised to continue the prednisolone acetate 1% eyedrops 6 times daily and to reduce it to 4 times daily after a week for the next 4 weeks. At 1 month, she was refracted to 20/40 N5, and the eye was quiescent. Optical coherence tomography showed that the macular was normal. The topical steroids were gradually tapered to the preoperative level.
However, a month later, she returned complaining of deteriorating vision while using twice-daily steroid eyedrops. Her CDVA was 20/60. Slitlamp examination revealed anterior capsule fibrosis and capsular phimosis, resulting in partial obstruction of the visual axis and mild decentration of the IOL superior temporally (Figure 1

JOURNAL/jcrs/04.03/02158034-202310000-00013/figure1/v/2023-10-10T172638Z/r/image-tiff

). The anterior segment was quiescent. The pupil could only be dilated to 4.5 mm despite the absence of posterior synechiae. Fundus examination revealed a normal-looking quiescent posterior segment. Her IOP was 16 mm Hg. UBM showed a thickened anterior capsule, intact zonular fibers, and a posteriorly bowed and decentered IOL within the capsular bag (Figure 2

JOURNAL/jcrs/04.03/02158034-202310000-00013/figure2/v/2023-10-10T172638Z/r/image-tiff

). She was referred for further management.
Discuss how you would manage this problem, explaining your decisions. How would you be able to avoid the same problem when operating on her fellow eye?
Sensing the body matters: profiles of interoceptive sensibility in chronic pain adjustment
Authors: Oliveira Inês , Vaz Garrido Margarida , Carvalho Helena , Figueira Bernardes Sónia 
Published: September 2023

Abstract
Interoception is critical to health regulation and is often disrupted in individuals with chronic pain (ICPs). Interoceptive sensibility (IS)—the self-reported experience and relationship toward internal states—includes skills such as sensing, interpreting, and using bodily information for self-regulation. Current studies on IS and chronic pain (CP) adjustment are scarce, and how the interplay between different IS skills shapes CP adjustment remains unclear. This cross-sectional study aimed to identify profiles of IS skills among ICPs and examined their associations with pain outcomes and psychological and behavioral risk or protective processes. Individuals with chronic musculoskeletal pain (n = 173; 84.4% women) completed the Multidimensional Assessment of Interoceptive Awareness (MAIA), measures of CP adjustment (depression, anxiety, vitality, pain severity, interference, and physical function), psychological (self-efficacy, catastrophizing, and kinesiophobia), and behavioral processes (activity patterns). A cluster analysis identified 3 IS skills profiles: (1) high IS skills (n = 68), with the highest levels of attention regulation toward bodily sensations, body trust, listening for insight, and self-regulation; (2) low IS skills (n = 29), who distracted less and worried more about bodily sensations, and presented lower-body trust; and (3) mixed IS skills (n = 71), despite good body trust, attention regulation, and low worrying, showed lower awareness of body–mind connections. Interoceptive sensibility skills profiles differed in depression, vitality (fatigue), and psychological or behavioral processes, such as pain-related self-efficacy, catastrophizing, kinesiophobia, and activity pacing. These findings contribute to integrating body–mind connections more explicitly into current theoretical CP models and developing tailored interventions targeting specific IS skills to improve CP adjustment.
Acute and Longer-Term Effects of COVID-19 on Auditory and Vestibular Symptoms
Authors: Berlot Ashley A. , Moskowitz Howard S. , Lin Juan , Liu Jianyou , Sehanobish Esha , Jerschow Elina , Ow Thomas J. , Sussman Elyse S. 
Published: September 2023

Objective
To evaluate long-term effects of COVID-19 on auditory and vestibular symptoms in a diverse cohort impacted by the initial 2020 COVID-19 infection in the pandemic's epicenter, before vaccine availability.

Study Design
Cohort study of individuals with confirmed COVID-19 infection, diagnosed in the March–May 2020 infection wave. A randomized, retrospective chart review of 1,352 individuals was performed to identify those with documented new or worsening auditory (aural fullness, tinnitus, hyperacusis, hearing loss) or vestibular (dizziness, vertigo) symptoms. Those with documented symptoms (613 of the 1,352 initial cohort) were contacted for a follow-up telephone survey in 2021–2022 to obtain self-report of aforementioned symptoms.

Setting
Academic tertiary hospital system in Bronx, NY.

Patients
Adults 18 to 99 years old with confirmed COVID-19 infection, alive at time of review. One hundred forty-eight charts were excluded for restricted access, incomplete data, no COVID-19 swab, or deceased at time of review.

Intervention
Confirmed COVID-19 infection, March to May 2020.

Main Outcomes Measures
Auditory and vestibular symptoms documented in 2020 medical records and by self-report on 2021 to 2022 survey.

Results
Among the 74 individuals with documented symptoms during the first 2020 COVID-19 wave who participated in the 2021 to 2022 follow-up survey, 58% had documented vestibular symptoms initially in 2020, whereas 43% reported vestibular symptoms on the 2021 to 2022 survey (p = 0.10). In contrast, 9% had documented auditory symptoms initially in 2020 and 55% reported auditory symptoms on the 2021 to 2022 survey (p < 0.01).

Conclusions
COVID-19 may impact vestibular symptoms early and persistently, whereas auditory effects may have more pronounced long-term impact, suggesting the importance of continually assessing COVID-19 patients.
Improving Situational Awareness to Decrease Emergency ICU Transfers for Hospitalized Pediatric Cardiology Patients
Authors: Cosgrove Tara C. , Gajarski Robert J. , Dolan Kevin F. , Hart Stephen A. , L’Italien Kaitlin E. , Kuehn Stacy , Ishmael Stephanie , Bowman Jessica L. , Fitch Jill A. , Hills Brittney K. , Bode Ryan S. 
Published: September 2023

Introduction:
Failure to recognize and mitigate critical patient deterioration remains a source of serious preventable harm to hospitalized pediatric cardiac patients. Emergency transfers (ETs) occur 10–20 times more often than code events outside the intensive care unit (ICU) and are associated with morbidity and mortality. This quality improvement project aimed to increase days between ETs and code events on an acute care cardiology unit (ACCU) from a baseline median of 17 and 32 days to ≥70 and 90 days within 12 months.

Methods:
Institutional leaders, cardiology-trained physicians and nurses, and trainees convened, utilizing the Institution for Healthcare Improvement model to achieve the project aims. Interventions implemented focused on improving situational awareness (SA), including a “Must Call List,” evening rounds, a visual management board, and daily huddles. Outcome measures included calendar days between ETs and code events in the ACCU. Process measures tracked the utilization of interventions, and cardiac ICU length of stay was a balancing measure. Statistical process control chart methodology was utilized to analyze the impact of interventions.

Results:
Within the study period, we observed a centerline shift in primary outcome measures with an increase from 17 to 56 days between ETs and 32 to 62 days between code events in the ACCU, with sustained improvement. Intervention utilization ranged from 87% to 100%, and there was no observed special cause variation in our balancing measure.

Conclusions:
Interventions focused on improving SA in a particularly vulnerable patient population led to sustained improvement with reduced ETs and code events outside the ICU.
Management of nonfermenting gram-negative infections: a critique of the guidelines
Authors: Bassetti Matteo , Vena Antonio , Giacobbe Daniele Roberto 
Published: September 2023

Purpose of review
In the present narrative review, we discuss the characteristics and differences between the Infectious Diseases Society of America (IDSA) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines in terms on their recommendations/suggestions for the treatment of Pseudomonas aeruginosa and Acinetobacter baumannii infections.

Recent findings
Treatment of severe infections caused by nonfermenting gram-negative bacteria (NF-GNB) is posing both novel hopes and novel challenges to physicians worldwide, and both the IDSA and the ESCMID have recently updated/released their guidelines or guidance documents, based on different philosophies and providing recommendations for the treatment of NF-GNB infections. In order to correctly exploit recent advances in the treatment of such infections, IDSA and ESCMID approaches should be viewed as complementary and evolving, and should not preclude further revision based on accumulating evidence on the use of novel β-lactams and β-lactam/β-lactamase inhibitor combinations.

Summary
A joint consideration of both philosophies should leave the door opened for the wise use of novel agents, ultimately building precious experience on their use that could favorably influence future guidelines revisions.
Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+regulation of neural activity
Authors: Latchoumane Charles-Francois V. , Lee Joon-Hyuk , Kim Seong-Wook , Kim Jinhyun , Shin Hee-Sup 
Published: September 2023

ABSTRACTThalamocortical activity is known to orchestrate sensory gating and consciousness switching. The precise thalamic regions involved, or the firing patterns related to the unconsciousness remain unclear. Interestingly, the highly-expressed thalamic T-type calcium currents have been considered as a candidate for the ionic mechanism for the generation of thalamo-cortically-driven change in conscious state. Here, we tested the hypothesis that Cav3.1 T-type channels in the mediodorsal thalamic nucleus (MD) might control neuronal firing during unconsciousness using Cav3.1 T-type channel knock-out (KO) and knock-down (KD) mice under natural sleep and ethanol-induced unconsciousness. During natural sleep, the MD neurons in KO mice showed general characteristics of sustained firing across sleep stages. We found that KO and MD-specific KD mice showed enhanced resistance to ethanol. During ethanol-induced unconscious state, wild-type (WT) MD neurons showed a significant reduction in neuronal firing from baseline with increased burst firing, whereas Cav3.1 KO neurons showed well sustained neural firing, within the level of wakefulness, and no burst firing. Further, 20 Hz optogenetic and electrical activation of MD neurons mimicked the ethanol resistance behavior in WT mice. These results suggest that maintaining MD neural firing at a wakeful level is sufficient to induce resistance to ethanol-induced hypnosis in WT mice. This work has important implications for the design of treatments for consciousness disorders using thalamic stimulation of deeper nuclei including the targeting of the mediodorsal thalamic nucleus.GRAPHICAL ABSTRACT
EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice
Authors: Jaune-Pons Emilie , Wang Xiaoyi , Mousavi Fatemeh , Elkaoutari Samad , Berger Kurt , Johnson Charis , Martin Mickenzie M. , Aggarwal Saloni , Brar Sukhman , Muhammad Khalid , Ryan Joanna , Shooshtari Parisa , Mathison Angela J. , Dusetti Nelson , Urrutia Raul , Lomberk Gwen , Pin Christopher L. 
Published: September 2023

AbstractEnhancer of Zeste Homologue 2 (EZH2) is part of the Polycomb Repressor Complex 2, which induces trimethylation of lysine 27 on histone 3 (H3K27me3) and promotes genes repression. EZH2 is overexpressed in many cancers including pancreatic ductal adenocarcinoma (PDAC). Previous studies in mice attributed both pro-oncogenic and tumor suppressive functions to EZH2. Deletion of the EZH2 enhancesde novoKRAS-driven neoplasia following pancreatic injury by preventing acinar cell regeneration, while increased EZH2 expression in PDAC is correlated to poor prognosis, suggesting a context-dependant effect for EZH2 in PDAC progression. In this study, we examined EZH2 function in pre-and early neoplastic stages of PDAC. Using an inducible model to generate deletion of EZH2 only in adult acinar cells (EZH2ΔSET), we showed loss of EZH2 activity did not prevent acinar cell regeneration in the absence of oncogenic KRAS (KRASG12D), nor lead to increased PanIN formation in the presence of KRASG12Din adult mice. However, loss of EZH2 did reduce recruitment of inflammatory cells and, when combined with a PDAC model, promoted widespread PDAC progression. Loss of EZH2 function also correlated to remodeling of the tumor microenvironment, which favors cancer cell progression. This study suggests expression of EZH2 in adult acinar cells restricts PDAC initiation and progression by affecting both the tumour microenvironment and acinar cell differentiation.
Individual Behavioral Variability Across Time and Contexts inDendrobates tinctoriusPoison Frogs
Authors: Soto Katharina M , Hardin Faith O , Alleyne Harmen P , Fischer Eva K 
Published: September 2023

AbstractConsistent individual differences in behavior (“animal personality”) have consequences for individual fitness, evolutionary trajectories, and species’ persistence. Such differences have been documented across a wide range of animals, though amphibians are generally underrepresented in this research area. The aim of our study was to examine consistent individual differences in Dyeing poison frogs,Dendrobates tinctorius. We evaluated repeatability in behaviors including activity, exploration, and boldness to assess consistency of behaviors across different temporal, experimental, and environmental contexts. We found repeatability in activity and exploration across time and contexts. In contrast, we observed context-specific behavior for our metrics of boldness, with consistent individual differences only for some measures. Further, while activity and exploration displayed consistent correlations across contexts, relationships between activity and boldness were context dependent. Our findings document the presence of consistent individual differences in behavior inD. tinctoriuspoison frogs, and also reveal context-dependent behavioral differences, highlighting the complex relationship between consistent individual differences and context-specific responses in animal behavior.Statement of SignificanceThe concept of animal personality centers on the existence of consistent individual differences in behavior. However, behavioral responses can depend on context, and consistent individual differences in one context do not guarantee consistent differences in another. To address this question, we assessed activity, exploration, and boldness in captive-bred poison frogs (Dendrobates tinctorius) across time and environmental contexts. Our comprehensive approach revealed consistent individual differences in some behaviors and context-specificity in others. While activity and exploration were generally repeatable and correlated with one another, boldness was not. Especially in view of the emphasis on measures of boldness in the animal personality literature, our findings emphasize the importance of reiterative and holistic approaches in the study of animal behavior.
Leaf δ13C reveals post-photosynthetic fractionation during ontogeny in a C4grass
Authors: Yu Yong Zhi , Liu Hai Tao , Yang Fang , Li Lei , Schäufele Rudi , Tcherkez Guillaume , Schnyder Hans , Gong Xiao Ying 
Published: September 2023

ABSTRACTThe13C isotope composition (δ13C) of leaf dry matter is a useful tool for physiological and ecological studies. However, how post-photosynthetic fractionation associated with respiration and carbon export influences δ13C remains uncertain. We investigated the effects of post-photosynthetic fractionation on δ13C of mature leaves ofCleistogenes squarrosa, a perennial C4grass, in controlled experiments with different levels of vapour pressure deficit and nitrogen supply. With the increase of leaf age classes, the12C/13C fractionation of leaf organic matter relative to the δ13C of atmosphere CO2(ΔDM) increased while that of cellulose (Δcel) was almost constant. The divergence between ΔDMand Δcelincreased with leaf age classes with a maximum value of 1.6‰, indicating the accumulation post-photosynthetic fractionation. Applying a new mass balance model that accounts for respiration and export of photosynthates, we found an apparent12C/13C fractionation associated with carbon export of –0.5 to –1.0‰. Different ΔDMamong leaves, pseudostems, daughter tillers and roots indicate that post-photosynthetic fractionation happens at the whole-plant level. Compared with ΔDMof old leaves, ΔDMof young leaves and Δcelare more reliable proxies for predicting physiological parameters due to the smaller sensitivity to post-photosynthetic fractionation and the similar sensitivity in responses to environmental changes.BRIEF SUMMARY STATEMENTΔ13C of bulk organic matter increases with leaf age classes while Δ13C of cellulose remain constant, lending support to the use of Δ13C of cellulose as a more reliable proxy for predicting physiological parameters due to the smaller sensitivity to post-photosynthetic fractionation.
Hematopoietic Stem Cells Undergo Differentiation State Reprogramming to Overcome Venetoclax Sensitivity in Patients with Myelodysplastic Syndromes
Authors: Rodriguez-Sevilla Juan Jose , Ganan-Gomez Irene , Ma Feiyang , Chien Kelly , Montalban-Bravo Guillermo , Kanagal-Shamanna Rashmi , Loghavi Sanam , Adema Vera , Bazinet Alexandre , Garcia-Manero Guillermo , Colla Simona 
Published: September 2023

ABSTRACTWhile the molecular mechanisms of acute myeloid leukemia failure to venetoclax-based therapy have been recently clarified, the mechanisms whereby patients with myelodysplastic syndromes (MDS) acquire secondary resistance to venetoclax after an initial response remain to be elucidated.Here, we show for the first time that MDS hematopoietic stem cells (HSCs) can undergo hierarchical differentiation reprogramming toward a granulo-monocytic-biased transcriptional state through the acquisition or expansion of clones with an isolated trisomy 8 cytogenetic aberration andSTAG2orRUNX1mutations. This hierarchical rewiring changes HSCs’ survival dependence from BCL-2-mediated anti-apoptotic pathways to TNFα-induced pro-survival NF-κB signaling and overcomes venetoclax-mediated cytotoxic effect. These findings underscore the importance of close molecular monitoring of patients with MDS enrolled in clinical trials of venetoclax to prevent HSC transcriptional reprogramming before the disease becomes resistant to this therapy.
Description ofProtosticta sexcoloratussp. nov. (Odonata, Platystictidae) from the Western Ghats, India
Authors: Chandran Ayikkara Vivek , Muneer P K , Madhavan M , Jose Subin K. 
Published: September 2023

ABSTRACTProtostictaSelys, 1885 is a speciose genus of damselflies distributed in the tropical and subtropical forests of Asia. During an ongoing study to document the odonate diversity of the Western Ghats, we came across a colony ofProtostictaspecies in Wayanad, Kerala, that appeared different from all other species hitherto described. We describe this population as a new species after detailed morphological comparison with closely similar species occurring in the region.
Unintended events in long-distance neonatal interhospital transport in Western Australia: A comparison of neonatal specialist and non-neonatal specialist transport teams
Authors: Gardiner Jacqueline , McDonald Kylie , Blacker Joanne , Athikarisamy Sam , Sharp Mary , Davis Jonathan 
Published: September 2023

AbstractObjectiveTo compare unintended events in transport performed by neonatal specialist (NS) and non-neonatal specialist (NNS) teams in Western Australia (WA).Study design: Retrospective comparison of neonatal transports from the Kimberley and Pilbara regions (WA) to tertiary services, King Edward Memorial (perinatal) and Perth Children’s Hospital NICU, in Perth (state capital, distance up to 2200km) between January 2018 - June 2021. NS teams travelled from the tertiary to the referring center and back. NNS travelled from the referring to the tertiary center. Transport time, team composition, total unintended clinical, endotracheal tube (ETT), and logistic events were compared. Categorial data are expressed as numbers (%) and compared by chi-squared test; continuous data are expressed as median (interquartile range) and compared by Mann-Whitney U test.ResultsDuring the study period, 3,709 infants were transported in WA to tertiary services for escalation of care: 119(3.2%) from the Kimberley and Pilbara, 49 with NS and 70 with NNS teams. NNS had shorter transport times than NS teams (508(435 – 609) vs 871(615 – 735) min; p<0.00001). Neonatal nurses were on NS more than NNS teams (36/49(73.5%) vs 6/70(9%); p<0.001). Total unintended clinical and ETT events were less in NS vs. NSS teams (28/49(57%) vs. 54/70(77%); p=0.02) and (0/26(0%) vs. 7/23(30%); p=0.004). Unintended logistic events were greater involving NS than NNS teams (31/49 (63%) vs. 33/70 (47%); p=0.05).ConclusionAlthough NS teams had longer transport times and more unintended logistic events, there were fewer unintended clinical and ETT events. NS teams should be considered as the first choice to undertake neonatal transport.