bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of caregiver preferences regarding research participation in the paediatric emergency department
Authors: Ma Keon , Rajagopal Manasi , Stang Antonia , Yaskina Maryna , Freedman Stephen B , Lerman Bethany , Ali Samina 
Published: November 2023

Abstract

Objectives
Emergency department (ED) visits can be stressful for families and can affect caregiver willingness to consent to participating in research. Our objective was to describe when and how caregivers wish to be informed about clinical research during their child’s ED visit.

Methods
An electronic survey was performed for families presenting to 10 Canadian paediatric EDs. A convenience sample of 1456 caregivers with children aged 0 to 17 years were enrolled. The survey tool was created (with an expert panel) using published methodological guidelines, including item generation/reduction, pre- and pilot-testing, and clinical sensibility assessment. Research-specific questions included the best time to be approached, the breadth of study opportunities presented, and best ways to encourage families to participate.

Results
Caregivers reported that the best times to be approached regarding research were in the waiting room (45.3%, 653/1441), after physician assessment (39.0%, 562/1441), or just prior to discharge (9.9%, 143/1441). 52.2% (351/672) wanted to hear about all available research studies, while 47.8% (321/672) wanted to be informed of studies relevant only to their child’s condition. Reported best ways to encourage families to participate in research included: incentives (e.g., gift cards/parking passes [31.2%, 230/737]), providing a clear explanation of study intent (30.7%, 226/737), and appealing to altruism (25.4%, 187/737).

Conclusions
There is wide variability in family preferences for timing of research-related conversations, suggesting that families could be approached in the waiting room, and if that is inconvenient or impractical, they could be offered a deferred conversation (i.e., after physician assessment or prior to discharge).
Loss of chromosome 9p21 is associated with a poor prognosis in adenosquamous carcinoma of the pancreas
Authors: Jiang Yina , Wu Yinying , Zhang Liwen , Wang Yan , Xu Guiping , Deng Yuan , Han Liang , Li Enxiao , Ma Qingyong , Xu Mian , Wu Zheng , Wang Zheng 
Published: November 2023

Abstract
Adenosquamous carcinoma of the pancreas (ASCP) is a rare histological subtype of pancreatic cancer with a poor prognosis and a high metastasis rate. However, little is known about its genomic landscape and prognostic biomarkers. A total of 48 ASCP specimens and 98 pancreatic ductal adenocarcinoma (PDAC) tumour specimens were sequenced to explore the genomic landscape and prognostic biomarkers. The homozygous deletion of the 9p21.3 region (including CDKN2A, CDKN2B, and MTAP) (9p21 loss) occurred in both ASCP and PDAC, and a higher frequency of 9p21 loss was observed in ASCP (12.5% vs 2.0%, P = 0.022). Notably, 9p21 loss was significantly associated with poor disease-free survival (DFS) in ASCP patients (mDFS (Median DFS) = 4.17 vs 7.33 months, HR (Hazard Ratio) = 3.70, P = 0.009). The most common gene alterations in patients with ASCP were KRAS (96%), TP53 (81%), CDKN2A (42%), SMAD4 (21%), CDKN2B (13%), and FAT3 (13%). The mutation rates of ACVR2A (6.25% vs 0%), FANCA (6.25% vs 0%), RBM10 (6.25% vs 0%), and SPTA1 (8.33% vs 1.02%) were significantly higher in ASCP than in PDAC. In conclusion, we have comprehensively described the genomic landscape of the largest cohort of ASCP patients to date and highlight that 9p21 loss may be a promising prognostic biomarker for ASCP, which provides a molecular basis for prognosis prediction and new therapeutic strategies for ASCP.
Revisiting Changes in Growth, Physiology and Stress Responses of Plants under the Effect of Enhanced CO2 and Temperature
Authors: Roy Swarnendu , Kapoor Rupam , Mathur Piyush 
Published: November 2023

Abstract
Climate change has universally affected the whole ecosystem in a unified manner and is known to have improbable effects on agricultural productivity and food security. Carbon dioxide (CO2) and temperature are the major environmental factors that have been shown to increase sharply during the last century and are directly responsible for affecting plant growth and development. A number of previous investigations have deliberated the positive effects of elevated CO2 on plant growth and development of various C3 crops, while detrimental effects of enhanced temperature on different crop plants like rice, wheat, maize and legumes are generally observed. A combined effect of elevated CO2 and temperature has yet to be studied in great detail; therefore, this review attempts to delineate the interactive effects of enhanced CO2 and temperature on plant growth, development, physiological and molecular responses. Elevated CO2 maintains leaf photosynthesis rate, respiration, transpiration and stomatal conductance in the presence of elevated temperature and sustains plant growth and productivity in the presence of both these environmental factors. Concomitantly, their interaction also affects the nutritional quality of seeds and leads to alterations in the composition of secondary metabolites. Elevated CO2 and temperature modulate phytohormone concentration in plants, and due to this fact, both environmental factors have substantial effects on abiotic and biotic stresses. Elevated CO2 and temperature have been shown to have mitigating effects on plants in the presence of other abiotic stress agents like drought and salinity, while no such pattern has been observed in the presence of biotic stress agents. This review focuses on the interactive effects of enhanced CO2 and temperature on different plants and is the first of its kind to deliver their combined responses in such detail.
Dryland Endolithic Chroococcidiopsis and Temperate Fresh Water Synechocystis Have Distinct Membrane Lipid and Photosynthesis Acclimation Strategies upon Desiccation and Temperature Increase
Authors: Douchi Damien , Si Larbi Gregory , Fel Benjamin , Bonnanfant Marlène , Louwagie Mathilde , Jouhet Juliette , Agnely Mathias , Pouget Stéphanie , Maréchal Eric 
Published: November 2023

Abstract
An effect of climate change is the expansion of drylands in temperate regions, predicted to affect microbial biodiversity. Since photosynthetic organisms are at the base of ecosystem’s trophic networks, we compared an endolithic desiccation-tolerant Chroococcidiopsis cyanobacteria isolated from gypsum rocks in the Atacama Desert with a freshwater desiccation-sensitive Synechocystis. We sought whether some acclimation traits in response to desiccation and temperature variations were shared, to evaluate the potential of temperate species to possibly become resilient to future arid conditions. When temperature varies, Synechocystis tunes the acyl composition of its lipids, via a homeoviscous acclimation mechanism known to adjust membrane fluidity, whereas no such change occurs in Chroococcidiopsis. Vice versa, a combined study of photosynthesis and pigment content shows that Chroococcidiopsis remodels its photosynthesis components and keeps an optimal photosynthetic capacity at all temperatures, whereas Synechocystis is unable to such adjustment. Upon desiccation on a gypsum surface, Synechocystis is rapidly unable to revive, whereas Chroococcidiopsis is capable to recover after three weeks. Using X-ray diffraction, we found no evidence that Chroococcidiopsis could use water extracted from gypsum crystals in such conditions as a surrogate for missing water. The sulfolipid sulfoquinovosyldiacylglycerol becomes the prominent membrane lipid in both dehydrated cyanobacteria, highlighting an overlooked function for this lipid. Chroococcidiopsis keeps a minimal level of monogalactosyldiacylglycerol, which may be essential for the recovery process. Results support that two independent adaptation strategies have evolved in these species to cope with temperature and desiccation increase and suggest some possible scenarios for microbial biodiversity change triggered by climate change.
A network analysis of pain intensity and pain-related measures of physical, emotional, and social functioning in US military service members with chronic pain
Authors: Wi Dahee , Park Chang , Ransom Jeffrey C , Flynn Diane M , Doorenbos Ardith Z 
Published: November 2023

Abstract

Objective
The purpose of this study was to apply network analysis methodology to better understand the relationships between pain-related measures among people with chronic pain.

Methods
We analyzed data from a cross-sectional sample of 4614 active duty service members with chronic pain referred to 1 military interdisciplinary pain management center between 2014 and 2021. Using a combination of Patient-Reported Outcomes Measurement Information System measures and other pain-related measures, we applied the “EBICglasso” algorithm to create regularized partial correlation networks that would identify the most influential measures.

Results
Pain interference, depression, and anxiety had the highest strength in these networks. Pain catastrophizing played an important role in the association between pain and other pain-related health measures. Bootstrap analyses showed that the networks were very stable and the edge weights accurately estimated in 2 analyses (with and without pain catastrophizing).

Conclusions
Our findings offer new insights into the relationships between symptoms using network analysis. Important findings highlight the strength of association between pain interference, depression and anxiety, which suggests that if pain is to be treated depression and anxiety must also be addressed. What was of specific importance was the role that pain catastrophizing had in the relationship between pain and other symptoms suggesting that pain catastrophizing is a key symptom on which to focus for treatment of chronic pain.
Is there a behavioral revolution in policy design? A new agenda and inventory of the behavioral toolbox
Authors: Esmark Anders 
Published: November 2023

Abstract
The article argues for a revised research on behavioral public policy focused on the core claim and sine qua non of a behavioral “revolution”: the ability to produce equal or better outcomes with less stringent policy designs than in traditional solutions, at least for certain types of problems. Three contributions to such an agenda are proposed. First, the article argues that the growing focus on the evaluation of real-world behavioral policy programs, as opposed to experimental studies within specialized areas of research, calls for a corresponding theoretical orientation toward existing literature on policy tools and design. Second, a doctrine of policy design is extrapolated from the broader behavioral paradigm and specified in relation to four general areas of application. These provide an essential context for the evaluation of the behavioral claim to improved policy design and highlight that behavioral successes may well, contra this claim, be a result of a de facto increase in stringency vis-à-vis traditional responses. Third, the article proposes a new and substantially revised inventory of the behavioral toolbox, which specifies the stringency, mechanisms, and potential costs of different behavioral tools and techniques, which is both essential to the evaluation of the behavioral claim and necessary to overcome the arbitrariness and mistakes of existing inventories.
The Unity of Perceptual Content
Authors: Reiland Indrek 
Published: November 2023

Abstract
Representationalists hold that perceptual experience is a conscious representational state with content, something which is accurate or inaccurate in certain conditions. The most common version of Representationalism takes perceptual content to be singular in the object-place and otherwise consisting of attribution of properties (Singularism/Attributionism). Schellenberg has recently developed a version on which perceptual content is singular even in the property-place in containing a de re mode of presentation of a property-instance (Particularism). In this paper, I show that Particularism faces a version of the problem of the Unity of Perceptual Content. Namely, its supporters haven’t told us how objects can be bound together with property-instances into a content such that it represents them and has accuracy-conditions. Furthermore, I argue that Particularists face an in-principle obstacle in solving it. In contrast, Attributionists can solve the problem and that establishes their view as the only game in town.
The Talented Tenth Meets the Twenty-First Century: Young, Gifted and Diverse in the Post-Affirmative Action Era
Authors: Davis Patricia G 
Published: November 2023

Abstract
In the wake of the Supreme Court's dismantling of affirmative action policies in higher education in its SFFA v. Harvard ruling, this review essay offers a detailed explication of the relevant themes Camille Z. Charles, Rory Kramer, Douglas Massey, and Kimberly C. Torres analyze in “Young, Gifted, and Diverse: Origins of the New Black Elite.” Taking DuBois's conceptualization of the “Talented Tenth” as their starting point, the authors present a combination of quantitative and qualitative research to examine the experiences and aspirations of Black students who matriculated to elite colleges over a decades-long period. This analysis expands Charles et al.'s intersecting themes of social mobility, colorism, and model minority discourses, situating them within a broader discursive field that includes the relevant historical and contemporary sociopolitical contexts as reflected in the Court's majority and dissenting opinions.
Heterogeneity of Tasks and Outcome Measures in Dual Tasking Studies in Children With Cerebral Palsy: A Scoping Review
Authors: Rubsam Meaghan , Girolami Gay L , Bhatt Tanvi 
Published: November 2023

Abstract

Objective
The aims of this scoping review are to examine the available literature regarding dual tasking in children with cerebral palsy (CP) and to identify and categorize both the motor and cognitive tasks and outcome measures used primarily through the International Classification of Functioning, Disability, and Health model.

Methods
Five electronic databases were searched. Studies were included if they: (1) were published in English; (2) included at least 1 group of children or adolescents with a diagnosis of CP; (3) assessed dual tasking as part of the study; (4) reported the method for performing the dual task; and (5) reported the outcome measures utilized.

Results
Twenty-three studies with 439 children with CP were included. All studies utilized motor activities as the primary task, including walking, balance, and a functional transition. Motor secondary tasks occurred in 10 studies, cognitive secondary tasks in 12 studies, and 1 study used both. Forty-one outcome measures over 23 studies assessed the body structure and function domain, 7 measures over 6 studies assessed activity limitations, and 2 outcomes over 2 studies assessed participation.

Conclusion
The 23 included studies demonstrated heterogeneity in the age and function of participants, secondary tasks, and outcome measures. Future studies on dual tasking in children with CP should consider the difficulty of the primary motor or cognitive task and compare secondary tasks to establish this contribution to motor performance. Studies should incorporate activity and participation measures to assess meaningful functional outcomes.

Impact
Children with CP experience challenges when exposed to dual task situations. This scoping review highlights the importance of considering multiple factors when designing dual tasking studies involving children with CP to facilitate results translation, improved participation, and enhanced function. Similarly, studies should utilize activity and participation outcomes to assess quality of life.
Effect of ursodeoxycholic acid on preventing SARS-CoV-2 infection in patients with liver transplantation: a multicenter retrospective cohort study
Authors: Hu L , Zhang H , Huang C , Shen T , Feng Z , Mu F , Xu L , Lin Y , Yue C , Guo K , Tian M , Shi J , Zhang C , Wen P , Cao S , Wang Y , Zhang J , Shi X , Wang Z , He Y , Zhang X , Liu X , Lv Y , Liu Z , Guo W , Wang B 
Published: November 2023

Summary

Background
Immunosuppressed recipients of liver transplantation (LT) are more likely to develop coronavirus disease 2019 (COVID-19) and may have an increased risk of developing worse outcomes.

Aim
To assess the effect of ursodeoxycholic acid (UDCA) on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in LT recipients.

Design
Adult patients (aged ≥ 18 years) who underwent LT between 1 January 2015 and 31 December 2022 were included and categorized into two groups according to their use of UDCA.

Methods
The prevalence and severity of COVID-19 among transplantation patients between the UDCA and non-UDCA groups were estimated and compared.

Results
Among the 897 LT patients who met the inclusion criteria, infection rate of SARS-CoV-2 was 78.4%, and the rate of severe illness was 5.1% from January 2022 to January 2023 in China. In the multivariate analysis, only UDCA treatment (P = 0.006) was found to be a protective factor against SARS-CoV-2 infection. After propensity score matching, the SARS-CoV-2 infection rate in the UDCA group was lower than that in the non-UDCA group (74.1% vs. 84.6%, P = 0.002). This rate was further reduced to 62.1% (P = 0.002) when the oral administration dose was &gt;15 mg/kg/day. There was no difference in the rates of severe COVID-19 illness, ICU admission, or ventilation rate or length of hospital stay with or without UDCA treatment (all P &gt; 0.05).

Conclusions
The use of UDCA in LT patients significantly reduced the SARS-CoV-2 infection rate and showed a dose-dependent protective effect.
“Safe Legal Pathways” or New Colonial Frontiers? A Critical Analysis of European Intervention in the Sahel and the Creation of Anomalous Legal Zones
Authors: Zagor Matthew 
Published: November 2023

Abstract
This article critiques the increasingly popular concept of the “safe legal pathway” in refugee politics, policy and law, using European engagement and intervention in the Sahel as its primary case study. It draws upon neo-colonial studies, necropolitics, border studies and the legal literature on sovereignty and extraterritoriality to explore the function, structure, and import of the “safe legal pathway”, and its compatibility with contemporary understandings of international legal history and argumentation. Divided into four sections, the article focuses on the drivers behind Europe’s migration-development-security objectives in the Sahelout of which the pathways discourse emerges, the EU’s concomitant insistence on criminalising the illusive “people smuggling business model”, and the role which the traditional tropes of sovereignty, territory, and civilisation play in determining policy parameters. Noting the multidirectional nature and multifunctional purposes of pathways, and focusing on the policing of migrant communities both within and outside Europe, this article provides a comprehensive and critical overview of the nature, structure, function, and regulation of the pathway, its susceptibility to being leveraged for the commodification, extraction, discipline and transformation of non-European bodies and narratives, and its place in the creation of differentiated, suspended, and anomalous legal zones for the transfer and manipulation of global norms.
Assaying Effector Cell-to-Cell Mobility in Plant Tissues Identifies Hypermobility and Indirect Manipulation of Plasmodesmata
Authors: Ohtsu Mina , Jennings Joanna , Johnston Matthew , Breakspear Andrew , Liu Xiaokun , Stark Kara , Morris Richard J. , de Keijzer Jeroen , Faulkner Christine 
Published: November 2023

In plants, plasmodesmata establish cytoplasmic continuity between cells to allow for communication and resource exchange across the cell wall. While plant pathogens use plasmodesmata as a pathway for both molecular and physical invasion, the benefits of molecular invasion (cell-to-cell movement of pathogen effectors) are poorly understood. To establish a methodology for identification and characterization of the cell-to-cell mobility of effectors, we performed a quantitative live imaging-based screen of candidate effectors of the fungal pathogen Colletotrichum higginsianum. We predicted C. higginsianum effectors by their expression profiles, the presence of a secretion signal, and their predicted and in planta localization when fused to green fluorescent protein. We assayed for cell-to-cell mobility of nucleocytosolic effectors and identified 14 that are cell-to-cell mobile. We identified that three of these effectors are “hypermobile,” showing cell-to-cell mobility greater than expected for a protein of that size. To explore the mechanism of hypermobility, we chose two hypermobile effectors and measured their impact on plasmodesmata function and found that even though they show no direct association with plasmodesmata, each increases the transport capacity of plasmodesmata. Thus, our methods for quantitative analysis of cell-to-cell mobility of candidate microbe-derived effectors, or any suite of host proteins, can identify cell-to-cell hypermobility and offer greater understanding of how proteins affect plasmodesmal function and intercellular connectivity. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Recognizing postural orthostatic tachycardia syndrome in primary care
Authors: Hulsey Brittney 
Published: November 2023

ABSTRACT
Postural orthostatic tachycardia syndrome (POTS) is a complex autonomic disorder characterized by abnormal tachycardia on standing. This disorder predominantly affects young women, with a peak incidence between ages 20 and 30 years. POTS often is associated with a variety of symptoms, including dizziness, palpitations, fatigue, generalized weakness, anxiety, and exercise intolerance, which can significantly impair patient quality of life. Primary care providers (PCPs) often are the first healthcare professionals to whom patients present. This article provides an overview of POTS, including diagnostic criteria and the importance of a thorough clinical evaluation to rule out other causes of symptoms. PCPs play a critical role in the comprehensive approach to care, involving patient education, lifestyle modifications, and treatment to improve outcomes and enhance patient quality of life.