bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming strength-toughness trade-off in a eutectic high entropy alloy by optimizing chemical and microstructural heterogeneities
Authors: Chen Zhaoqi , Zhu Wenqing , Wang Hang , He Quanfeng , Fang Qihong , Liu Xiaodi , Li Jia , Yang Yong 
Published: February 2024

AbstractThe well-known strength-toughness trade-off has long been an obstacle in the pursuit of advanced structural alloys. Here, we develop a eutectic high entropy alloy that effectively overcomes this limitation. Our alloy is composed of face-centered cubic and body-centered cubic crystalline phases, and demonstrates attractive mechanical properties by harnessing microstructural hybridization and a strain-induced phase transition between phases. Unlike conventional eutectic alloys, the compositionally complexity of our alloy allows control of its microstructural and chemical heterogeneities across multiple length scales, ranging from atomic- and nano-scales to meso-scales. Optimizing these microstructural and chemical heterogeneities within our alloy enables high strength and ductility because of enhanced fracture resistance, outperforming alternative high and medium entropy alloys with similar compositions and microstructures.
Unequal impact of climate warming on meat yields of global cattle farming
Authors: Liu Weihang , Zhou Junxiong , Ma Yuchi , Chen Shuo , Luo Yuchuan 
Published: February 2024

AbstractClimate warming affects global livestock productivity. The meat yield from cattle farming (cattle meat per animal) represents livestock productivity at the individual level. However, the impact of warming on cattle meat yield at a global scale is not well understood. In this study, we combine country-level data on the annual meat yield from cattle farming and socioeconomic data from 1961 to 2020 with climate projections from General Circulation Models. The findings show that cattle meat yield increases as temperatures rise from low to medium and then decreases when annual average temperatures exceed 7 °C; this repose is pronounced in the grassland-based livestock system. Further, we show that warming creates unequal impacts between high- and low-income countries due to the divergent baseline temperature conditions. Future warming aggravates these unequal burdens between countries, with the most pronounced effects observed under the upper-middle emissions scenario.
3D electromagnetic modelling for high‐temperature superconducting dynamo flux pumps using T‐A formulation
Authors: Hao Luning , Dong Fangliang , Hu Jintao , Wang Qi , Wei Haigening , Patel Ismail , Shah Adil , Wu Yuyang , Coombs Tim 
Published: February 2024

AbstractA high‐temperature superconducting (HTS) dynamo flux pump can inject DC currents into closed‐loop HTS magnets without contact. It enables the realisation of current‐lead‐free or even through‐wall charging systems for high‐field applications such as nuclear magnetic resonance/magnetic resonance imaging (MRI) magnets, fusion reactors and accelerators. Researchers have proposed many simulation models to understand the working principle of HTS dynamos, few of which are in 3D because of converging problems. Therefore, the influences of many key 3D parameters in the HTS dynamo are scarcely reported. The authors propose an efficient 3D modelling method of the HTS dynamo based on the T‐A formulation. The rotating magnets are modelled by a ring‐shaped permanent magnet with space‐time‐variant remanent flux density to avoid moving meshes. This, together with the T‐A formulation, makes the 3D model efficient and universal. The accuracy of the model is verified by the experimental instantaneous and time‐integrated dynamic voltages. Using this model, the authors present systematic case studies to thoroughly explore the influences of the key parameters of a dynamo flux pump on the dynamic voltage and losses. The proposed modelling method and results could significantly benefit the design and optimisation of HTS dynamos for high‐field magnets.
Social identity development in transnational marriages of international students in China
Authors: Raja Rameez , Ma Jianfu , Tao Rui , Ullah Shakir , Li Xi Yuan , Shafi Malik Muhammad 
Published: February 2024

AbstractIn recent years, the increasing trend of transnational marriages between international students in China and Chinese nationals has provided unique insights into Chinese society. This paper explores how these unions contribute to the development of social identities. Data was collected through participant observation and in-depth interviews with 15 heterosexual couples. Analysis of the findings supported the idea that these marriages foster a deeper understanding of the couples’ identities and those of their partners by expanding social networks. Identity construction in such unions increases tolerance, mutual understanding, and more flexible family relationships. This exchange of cultures also results in greater familiarity with cultural assumptions and enhanced acceptance of mutual influence, leading to positive adjustments within the host society.
Transforming power of research and development on inequality and well-being: a European Union perspective within the circular economy framework
Authors: Skare Marinko , Gavurova Beata , Rigelsky Martin 
Published: February 2024

AbstractTo establish a “well-being economy” that prioritizes human and environmental welfare, understanding the relationship between income inequality, research and development (R&D) potential, and human development is crucial. This study delves into these relationships in European Union (EU) countries, focusing on the adoption levels of a circular economy (CE). Analyzing data from the 27 EU member countries spanning 2010 to 2020, a cluster analysis was utilized to categorize nations based on their CE adoption levels. The panel regression analysis findings revealed a marked positive correlation between income and R&D, with countries having a more robust CE adoption showing stronger ties. Furthermore, a notable positive link was discerned between R&D and human development indicators. Despite these significant relationships, the government R&D sector exhibited inefficiencies, especially in countries with heightened CE adoption. These findings carry profound implications for policymakers, urging a redefinition of economic growth metrics and a shift toward a well-being economy that emphasizes human and environmental health.
The effect of transformational leadership and personal cultural values on creating a learning organization
Authors: Şahin Nurşen , Bilir F. Pervin 
Published: February 2024

AbstractThis research aims to investigate the effect of transformational leadership and personal cultural values on creating a learning organization in the field of physical education and sports in higher education institutions. The sample consisted of 328 academic staff selected through convenience sampling. These participants worked in the field of physical education and sports in higher education institutions and volunteered for the research. The data of the study were collected through “Learning Organization Dimensions Scale” developed by Watkins and Marsick (1997), “Transformational Leadership Scale” by Podsakoff et al. (1990), and “Personal Cultural Values Scale” by Yoo et al. (2011). For the data analysis, Scatter Plot Matrix distributions, multivariate Mardia normality test, and structural equation modeling were utilized. In the creation of a learning organization, it was observed that there was a direct effect of providing vision-inspiration and being an appropriate role model, providing acceptance of group goals, giving intellectual encouragement, paying individual interest, and having high success expectations sub-dimensions of transformational leadership and power distance and collectivism sub-dimensions of personal cultural values. Transformational leadership and personal cultural values are essential for constructing a learning organization. The research can contribute to the development of higher education institutions and their evolution into a learning organization by determining the interaction of the learning organization, transformational leadership, and personal cultural values.
Three Modalities of (Originalist) Fiduciary Constitutionalism
Authors: Leib Ethan J 
Published: February 2024

Abstract
There is an ongoing body of scholarship in contemporary constitutional theory and legal history that can be labeled ‘fiduciary constitutionalism’. Some have wanted to strangle this work in its cradle, offering an argument pitched ‘against fiduciary constitutionalism’, full stop. But because there are enough different modalities of fiduciary constitutionalism—and particularly originalist varieties of it at the center of recent critiques—it is worth getting clearer about some methodological commitments of this work to help evaluate its promise and potential pitfalls. This article develops the ambitions, successes, and deficiencies of three modalities of historical and originalist argument that link American constitutionalism with the law and theory that constrains those with especial discretion and control over the legal and practical resources of beneficiaries known as fiduciary governance. Probing primary and secondary research in fiduciary constitutionalism can help show its value and limitations for legal historians and constitutional theorists alike.
Removal and the Changing Debate over Executive Power at the Founding
Authors: Gienapp Jonathan 
Published: February 2024

Abstract
The enduring and protracted debate over the original scope of American presidential power often reduces to a simple question: What did the words ‘executive power’ in the Article II vesting clause of the US Constitution originally mean? Yet this singular preoccupation has concealed a crucial historical transformation. To bring this underappreciated shift into focus, this article offers four observations on the great 1789 congressional debate over the removal of executive officers: first, the debate was unexpected; second, it covered new ground; third, during the course of it, participants openly changed their minds; fourth, it remained unresolved until the end. Rather than attempting to settle the issue of removal that has divided scholars and jurists for so long, this article instead offers these observations in hopes of redirecting our focus: to see that the removal debate was marked by uncertainty and confusion because the debate over executive power was itself changing at this time. Eighteenth-century Americans had been debating executive power since long before declaring independence, but the question that had animated that debate for close to a century began to change after the Constitution was ratified. As the question mutated, so too did the dispute itself, and, with that, understandings of executive power. The removal debate was one of the key markers of this important transformation. There remains no shortage of interest in the historical foundations of presidential power. We misapprehend what Founding-era Americans thought about executive power unless we appreciate how the framework of debate was itself changing at the time of the Constitution’s birth.
New uses for an old technique: live imaging on the slice organ culture to study reproductive processes
Authors: Amato Ciro Maurizio , Yao Humphrey Hung-Chang 
Published: February 2024

Abstract
Reproductive processes are dynamic and involve extensive morphological remodeling and cell–cell interactions. Live imaging of organs enhances our understanding of how biological processes occur in real time. Slice culture is a type of organ culture where thick slices are collected from an organ and cultured for several days. Slice culture is a useful and easy-to-implement technique for live imaging of reproductive events at cellular resolution. Here we describe a pipeline of live imaging on slice culture to visualize the process of urethra closure in mouse embryonic penis as a proof of principle. In combination with genetic reporter mice, nuclear stains, and exposure experiments, we demonstrate the feasibility of slice culture on a reproductive organ. We also provide a step-by-step protocol and troubleshooting guide to facilitate the adoption of slice culture with live imaging in other reproductive organs. Lastly, we discuss potential utilities and experiments that could be implemented with slice culture in reproductive sciences.
Synthesis, cation exchange, and optical properties of pyrene-based chromophores containing [CB9H9]− and [CB11H11]− cluster units
Authors: Ochi Junki , Yanagihara Takumi , Tanaka Kazuo , Chujo Yoshiki 
Published: February 2024

Abstract
Four monocarborane anion-based compounds connected to a pyrene moiety were synthesized by combining two monocarborane anion scaffolds and two counter cations. The effects of the cage structure and the counter cation on the optical properties were investigated from UV‒vis absorption and photoluminescence (PL) measurements. The PL spectra in the solid state were unique for each compound, derived from the different shapes of the carborane cage and counter cation. These results suggest great potential for designing a monocarborane anion-based chromophore.
The cGAS-STING pathway: a therapeutic target in diabetes and its complications
Authors: He Wenjie , Mu Xingrui , Wu Xingqian , Liu Ye , Deng Junyu , Liu Yiqiu , Han Felicity , Nie Xuqiang 
Published: February 2024

Abstract
Diabetic wound healing (DWH) represents a major complication of diabetes where inflammation is a key impediment to proper healing. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has emerged as a central mediator of inflammatory responses to cell stress and damage. However, the contribution of cGAS-STING activation to impaired healing in DWH remains understudied. In this review, we examine the evidence that cGAS-STING-driven inflammation is a critical factor underlying defective DWH. We summarize studies revealing upregulation of the cGAS-STING pathway in diabetic wounds and discuss how this exacerbates inflammation and senescence and disrupts cellular metabolism to block healing. Partial pharmaceutical inhibition of cGAS-STING has shown promise in damping inflammation and improving DWH in preclinical models. We highlight key knowledge gaps regarding cGAS-STING in DWH, including its relationships with endoplasmic reticulum stress and metal-ion signaling. Elucidating these mechanisms may unveil new therapeutic targets within the cGAS-STING pathway to improve healing outcomes in DWH. This review synthesizes current understanding of how cGAS-STING activation contributes to DWH pathology and proposes future research directions to exploit modulation of this pathway for therapeutic benefit.
Safety and efficacy of glucagon-like peptide-1 receptor agonists among kidney transplant recipients: a systematic review and meta-analysis
Authors: Krisanapan Pajaree , Suppadungsuk Supawadee , Sanpawithayakul Kanokporn , Thongprayoon Charat , Pattharanitima Pattharawin , Tangpanithandee Supawit , Mao Michael A , Miao Jing , Cheungpasitporn Wisit 
Published: February 2024

ABSTRACT

Background
Evidence supporting glucagon-like peptide-1 receptor agonists (GLP-1RAs) in kidney transplant recipients (KTRs) remains scarce. This systematic review and meta-analysis aims to evaluate the safety and efficacy of GLP-1RAs in this population.

Methods
A comprehensive literature search was conducted in the MEDLINE, Embase and Cochrane databases from inception through May 2023. Clinical trials and observational studies that reported on the safety or efficacy outcomes of GLP-1RAs in adult KTRs were included. Kidney graft function, glycaemic and metabolic parameters, weight, cardiovascular outcomes and adverse events were evaluated. Outcome measures used for analysis included pooled odds ratios (ORs) with 95% confidence intervals (CIs) for dichotomous outcomes and standardized mean difference (SMD) or mean difference (MD) with 95% CI for continuous outcomes. The protocol was registered in the International Prospective Register of Systematic Reviews (CRD 42023426190).

Results
Nine cohort studies with a total of 338 KTRs were included. The median follow-up was 12 months (interquartile range 6–23). While treatment with GLP-1RAs did not yield a significant change in estimated glomerular filtration rate [SMD −0.07 ml/min/1.73 m2 (95% CI −0.64–0.50)] or creatinine [SMD −0.08 mg/dl (95% CI −0.44–0.28)], they were associated with a significant decrease in urine protein:creatinine ratio [SMD −0.47 (95% CI −0.77 to −0.18)] and haemoglobin A1c levels [MD −0.85% (95% CI −1.41 to −0.28)]. Total daily insulin dose, weight and body mass index also decreased significantly. Tacrolimus levels remained stable [MD −0.43 ng/ml (95% CI −0.99 to 0.13)]. Side effects were primarily nausea and vomiting (17.6%), diarrhoea (7.6%) and injection site pain (5.4%).

Conclusions
GLP-1RAs are effective in reducing proteinuria, improving glycaemic control and supporting weight loss in KTRs, without altering tacrolimus levels. Gastrointestinal symptoms are the main side effects.
Partitioned 2D Set-Pruning Segment Trees with Compressed Buckets for Multi-Dimensional Packet Classification
Authors: Chang Yeim-Kuan , Chen Hsin-Mao 
Published: February 2024

Abstract
Multi-dimensional packet classification is one of the most important functions to support various services in next generation routers. Both the memory-efficient data structure to support larger rule tables and the hardware architecture to achieve a higher throughput are desired. In this paper, we propose a parallel and pipelined architecture called Set-Pruning Segment Trees with Buckets (SPSTwB) for multi-dimensional packet classification. SPSTwB significantly reduces rule duplication based on a novel partitioning scheme and an efficient bucket merging scheme. The key feature of our proposed architecture is that memory consumption is reduced significantly regardless of the characteristics of various rule tables. In addition, the logic complexity of each pipeline stage is simplified by not storing rule IDs and priorities and thus it can run at a high clock rate. The proposed scheme needs less than 20 bytes per rule for various 100 K rule tables generated by ClassBench. In addition, the proposed scheme supports fast incremental rule update. The proposed pipelined architecture can achieve a throughput of 134 Gbps from the implementation on Xilinx Virtex-7 FPGA device with dual-ported Block RAM.
Joint Alignment Networks For Few-Shot Website Fingerprinting Attack
Authors: Zhou Qiang , Wang Liangmin , Zhu Huijuan , Lu Tong , Song Heping 
Published: February 2024

Abstract
Website fingerprinting (WF) attacks based on deep neural networks pose a significant threat to the privacy of anonymous network users. However, training a deep WF model requires many labeled traces, which can be labor-intensive and time-consuming, and models trained on the originally collected traces cannot be directly used for the classification of newly collected traces due to the concept drift caused by the time gap in the data collection. Few-shot WF attacks are proposed for using the originally and few-shot newly collected labeled traces to facilitate anonymous trace classification. However, existing few-shot WF attacks ignore the fine-grained feature alignment to eliminate the concept drift in the model training, which fails to fully use the knowledge of labeled traces. We propose a novel few-shot WF attack called Joint Alignment Networks (JAN), which conducts fine-grained feature alignment at both semantic-level and feature-level. Specifically, JAN minimizes a distribution distance between originally and newly collected traces in the feature space for feature-level alignment, and utilizes two task-specific classifiers to detect unaligned traces and force these traces mapped within decision boundaries for semantic-level alignment. Extensive experiments on public datasets show that JAN outperforms the state-of-the-art few-shot WF methods, especially in the difficult 1-shot tasks.
Fat mass and obesity-associated protein (FTO) affects midpalatal suture bone remodeling during rapid maxillary expansion
Authors: Zhao Tingting , Tao Zhendong , Zhang Gengming , Zhu Jiaqi , Du Mingyuan , Hua Fang , He Hong 
Published: February 2024

Abstract

Background
The fat mass and obesity-associated protein (FTO) is an RNA demethylase that contributes to several physiological processes. Nonetheless, the impact of FTO on bone remodeling in the midpalatal suture while undergoing rapid maxillary expansion (RME) remains unclear.

Methods
First, to explore the expression of FTO in the midpalatal suture during RME, six rats were randomly divided into two groups: Expansion group and Sham group (springs without being activated). Then, suture mesenchymal stem cells (SuSCs) were isolated as in vitro model. The expression of FTO was knocked down by small interfering RNA to study the effect of FTO on the osteogenic differentiation of SuSCs. Finally, to evaluate the function of FTO in the process of bone remodeling in the midpalatal suture, ten rats were randomly divided into two groups: FB23-2 group (10 μM, a small molecule inhibitor of FTO) and DMSO group (control).

Results
Increased arch width and higher expression of OCN and FTO in the midpalatal area were observed in expansion group (P &lt; .05). In the in vitro model, the mRNA expression levels of Runx2, Bmp2, Col1a1, Spp1, and Tnfrsf11b were decreased (P &lt; .05) upon knocking down FTO. Additionally, the protein levels of RUNX2 and OPN were also decreased (P &lt; 0.05). Adding FB23-2, a small-molecule inhibitor targeting FTO, to the medium of SuSCs caused a decrease in the mRNA expression levels of Runx2, Bmp2, Col1a1, Spp1, and Tnfrsf11b (P &lt; 0.05). There was a statistically significant difference in evaluating the expression of OCN and OPN on the palatal suture between the FB23-2 and DMSO groups (P &lt; .05).

Limitation
The molecular mechanisms by which FTO regulates SuSCs osteogenesis remain to be elucidated. The FTO conditional knock out mouse model can be established to further elucidate the role of FTO during RME.

Conclusion
FTO contributes to the osteogenic differentiation of SuSCs and plays a promoting role in midpalatal suture bone remodeling during the RME.
The reproductive microbiome and maternal transmission of microbiota via eggs in Sceloporus virgatus
Authors: Bunker Marie E , Weiss Stacey L 
Published: February 2024

Abstract
Maternal transmission of microbes occurs across the animal kingdom and is vital for offspring development and long-term health. The mechanisms of this transfer are most well-studied in humans and other mammals but are less well-understood in egg-laying animals, especially those with no parental care. Here, we investigate the transfer of maternal microbes in the oviparous phrynosomatid lizard, Sceloporus virgatus. We compared the microbiota of three maternal tissues—oviduct, cloaca, and intestine—to three offspring sample types: egg contents and eggshells on the day of oviposition, and hatchling intestinal tissue on the day of hatching. We found that maternal identity is an important factor in hatchling microbiome composition, indicating that maternal transmission is occurring. The maternal cloacal and oviductal communities contribute to offspring microbiota in all three sample types, with minimal microbes sourced from maternal intestines. This indicates that the maternal reproductive microbiome is more important for microbial inheritance than the gut microbiome, and the tissue-level variation of the adult S. virgatus microbiota must develop as the hatchling matures. Despite differences between adult and hatchling communities, offspring microbiota were primarily members of the Enterobacteriaceae and Yersiniaceae families (Phylum Proteobacteria), consistent with this and past studies of adult S. virgatus microbiomes.