bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Medication-Related Challenges in Hypertensive Patients: A Comprehensive Assessment at Community Based Medical College, Bangladesh (CBMC,B) Hospital
Authors: Sattar Shamima 
Published: February 2025

A cross-sectional, observational study was carried out at Community Based Medical College, Bangladesh (CBMC,B) Hospital, Mymensingh, Bangladesh, between January and September of 2023, to assess the proportion and nature of drug therapy problems, the regimen management of hypertension, and the associated risks among hypertensive patients. A total of 120 hypertensive patients willingly participated and responded to a structured questionnaire. Patient data include demographic characteristics, medications, clinical parameters, lifestyle factors, and drug therapy issues. The study included an equal distribution of males and females, with most patients aged 49-58 years (29.2%). Telmisartan (62.5%) and amlodipine (50.0%) were the most commonly prescribed medications. Among drug therapy problems (DTPs), need for monitoring (35%) and potential drug interactions (31.67%) were found most significant. Diabetes mellitus (37.50%) and chronic kidney disease (25.83%) were main comorbidities. Stress (50%) and unhealthy diet (49.17%) emerged as leading risk factors, while polypharmacy (55%) and comorbidities (53.33%) in patients emerged as main clinical challenges. This study suggests that medication review processes need to be well structured, resources required for improving the patients’ knowledge about hypertension and its treatments are necessary for healthcare organizations in the country and monitoring activities ought to be conducted from time to time to review the management of hypertension.
CBMJ 2025 January: Vol. 14 No. 01 P: 128-133
Epidemiological Profile Autoimmune Bullous Diseases: A Study Done in A Tertiary Care Hospital in Bangladesh
Authors: Islam Nahida , Shakil Mohammad Imdadul Hoque 
Published: February 2025

A cross-sectional study was conducted in the Department of Dermatology and Venereology, Community Based Medical College, Bangladesh (CBMC,B), Mymensingh, Bangladesh, between March 2022 and March 2024, to evaluate the epidemiology of autoimmune bullous diseases (AIBDs). A total of 89 patients diagnosed with autoimmune bullous diseases (AIBDs) were enrolled in this study using a purposive sampling method. All demographic and clinical information was documented. Most of our participants were aged 60 years or older (53.9%). A male predominance was observed (59.6%). The most prevalent type of AIBD was pemphigus vulgaris (59.6%). Hypertension (12.4%), diabetes mellitus (7.9%), hyperlipidemia (5.6%), osteoporosis (4.5%), coronary heart disease (3.4%) and hepatitis (3.4%) were observed as the main comorbidities. In nearly three-fourths of the cases (74%) only oral mucosal involvement was identified, while only nasal (2%), only genital (8%), and both oral and genital (16%) mucosal involvement were also observed. Overall, our data showed that the older male population is mainly prone to autoimmune bullous diseases (AIBDs) in Bangladesh.
CBMJ 2025 January: Vol. 14 No. 01 P: 134-138
In Silico Design and Evaluation of a Novel Multi-Epitope Vaccine Against Treponema denticola (strain ATCC 35405): A Reverse Vaccinology Approach
Authors: Chowdhury Ashiqur Rahman Khan , Paul Aurpita Rani , Tamanna Nusrat Jahan , Ovi Mst Nafisa Omman , Momo Mehejabine Islam , Sarker Ruma , Moury Israt Jahan , Jahan Farjana , Rahman Evana , Shila Sabrina Akhter , Hasanat Hamja , Fahi Faria Hossain , Hossain M Mahboob 
Published: February 2025

Treponema denticola is a gram-negative, drug resistant bacterium found in primary dentition infections and around teeth, causing inflammation and tissue homeostasis linked to periodontal diseases including early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis. In previous research, potential drug targets against the pathogen had been identified and characterized. However, as of now, there are no vaccines specifically available against T. denticola for human use. Hence, this study aims to design an immunoinformatic vaccine using a reverse vaccinology approach against this deadly pathogen. Human (HLA) allele specific potential T-cell and B-cell epitopes were shortlisted through a stringent procedure from a total of two antigenic proteins of T. denticola (namely, Acetate kinase AckA and Chromosomal replication initiator protein DnaA). The multi-epitope vaccine (MEV) was constructed using linkers with adjuvant human beta-defensin-3. The vaccine construct was verified, based on its antigenicity and physicochemical properties, and showed strong binding with the human receptor (TLR4). Molecular dynamics simulation confirmed the stable nature of the docked complex. The results of in silico immune simulation revealed that constructed vaccine activated B and T lymphocytes which induced high levels of antibodies and cytokines. Furthermore, in silico cloning analysis ensured efficient expression of desired gene in the microbial system. Thus, the vaccine construct developed in this study is capable of eliciting both innate and adaptive immunity and has all the potential for the development of a next-generation vaccine which may in turn effectively combat the periodontal pathogen T. denticola. Nevertheless, further in vitro and animal studies are warranted to strengthen our findings for its utility as a probable preventive measure.
CBMJ 2025 January: Vol. 14 No. 01 P: 139-155
Scalability and Sustainability Issues of Mobile Learning in Health Professions Education
Authors: Nurunnabi Abu Sadat Mohammad , Rahman Ashiqur , Akter Nahida , Talukder Mohammad Abu Sayeed , Tapu Thanadar Tamjeeda , Rehana Jinnat , Nahar Niru Shamsun 
Published: February 2025

Mobile learning has been used increasingly in the past decades in different health profession education, and advancement in technology have produced different forms of mobile learning development modalities such as simulations, virtual patients, online courses and many interactive contents. However, many of those efforts’ outcomes failed to live up to their promises; hence, those were not widely adopted and became unsustainable. A literature review has been done through a literature search conducted across three databases – Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE (Ovid) and Google scholar – for studies describing or evaluating different mobile learning platform as used for education and professional development of different health professions based on user experience, perceived barriers, facilitating factors to scale it up and make it sustainable. This paper tends to identify factors or actions which are considered to optimize the experience and satisfaction of different stakeholders, help scaling up and identify strategies for sustainability of mobile learning interventions for health professions education.
CBMJ 2025 January: Vol. 14 No. 01 P: 186-191
Soil Organic Carbon and Nitrogen Storage and Distribution in the Agricultural Soils as Affected by Soil Depths and Inundation Land Types
Authors: Uddin M J , Mohiuddin A S M 
Published: February 2025

A study was initiated on soil organic carbon (SOC) and total nitrogen (TN) storage and their distribution as affected by soil depths and inundation land types selecting ideal two catena across eight soil profiles up to the depth of 120 cm in the Brahmaputra and the Ganges alluviums. Soil organic carbon and TN storage is higher in the surface soil depth than the other soil depths. The contents and distribution of SOC and TN in all the soil depths varies significantly. Moreover, inundation land types and soil depths exhibited a significant effect (p<0.001) on SOC and TN storage. Soil organic carbon and TN storage were higher in the lowland (LL) and medium lowland (MLL) sites than that in the highland (HL) and medium highland (MHL) sites across the alluviums, which indicates that the topographic variability as well as their water recession conditions which ultimately focuses on SOC loss or sequestration. The Brahmaputra alluvium possesses higher SOC and TN storage than the Ganges alluvium which may be due to the variability of their land use and local management practices. Proper emphasis should be given on sub soil depths and inundation levels in formulating any agricultural policy planning.
J. Asiat. Soc. Bangladesh, Sci. 50(1-2): 137-152, June-December 2024
Pontocerebellar Hypoplasia Type 6: A Rare Disorder in Two Siblings
Authors: Khan Husnea Ara , Parvin Jobaida , Saha Dipa , Hossain Sharmin , Hossain Mohammed Monir , Saha Narayan Chandra 
Published: February 2025

Pontocerebellar hypoplasia type 6 (PCH-6) is a mitochondrial disease caused by mutations in the RARS2 gene. It is characterized by severe neurodevelopmental impairment, progressive microcephaly, seizure, cerebellar and pontine hypoplasia. We present a detailed description of two siblings with PCH-6. They had similar symptoms like developmental delay, seizure, and microcephaly. Neuroimaging abnormalities were found in both patient but finding typical for PCH-6 was only found in patient-1. Whole-exome sequencing confirmed that both siblings harbored the same compound heterozygous c.1A>G (p. Met1?) and c.574_575delinsTT (p. Glu192leu) variant in RARS2 gene. This case report highlights the clinical features, and diagnosis of PCH-6 in two siblings. A heightened index of suspicion for PCH-6 is merited in infants with developmental delay, intractable seizure, and microcephaly.
J Bangladesh Coll Phys Surg 2025; 43: 93-97
Immune-mediated Neuropathies in Clinical Practice: A Narrative Review
Authors: Rahman Aminur 
Published: February 2025

The spectrum of immune-mediated polyneuropathies has expanded with the discovery of chronic, steroid-responsive polyneuropathy 50 years ago, and the identification of acute monophasic paralysis, later named Guillain-Barré syndrome, nearly a century ago. Numerous subtypes of these polyneuropathies are still being identified, such as multifocal motor neuropathy (MMN), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and paraproteinemic neuropathies (PN). Most of these illnesses are thought to be brought on by autoimmunity against proteins found at the node of Ranvier or peripheral nerve myelin; however, not all disorders have been linked to disease-associated autoantibodies. The presence of certain anti-glycoconjugate antibodies suggests a molecular mimicking mechanism at work and can help classify these illnesses, albeit this approach often just confirms the clinical diagnosis. Presently, multifocal motor neuropathy with conduction block, another subgroup of treatable motor neuropathies, is characterized by the electrophysiological presence of conduction blocks. The many kinds of immune-mediated neuropathies make it difficult to make the correct diagnosis in day-to-day clinical practice. Immunotherapies, such as plasma exchange, intravenous immunoglobulin, and corticosteroids, are typically used in the therapy of these illnesses. The treatment choices for these debilitating diseases should be expanded by advancements in clinical criteria and the development of further immunotherapies targeted to individual diseases. The aim of this review is to get a glimpse at these different perspectives that may aid these diseases practical approach to diagnosis, management and prognosis.
J Bangladesh Coll Phys Surg 2025; 43: 59-76
Efficacy of Intra-cameral Mydriatic and Anesthetics- in Small Incision Cataract Surgery (SICS)
Authors: Mahmud ul Huda Md , Abdul Khaleque Sajed , Zinnurain Md , Hossain Md Musharraf , Jannat Munjifa Rowjatul 
Published: February 2025

Introduction: Aim: To observe the per operative efficacy (in term of time of papillary dilatation and its maintenance till end of the surgery) of intra-cameral mydriatic and anesthetics(tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%) (ICM) in small incision cataract surgery (SICS). Materials and Methods: This is a cross sectional analytical study done in the department of ophthalmology Sheikh Hasina Medical College Jamalpur, from 27 April 2022 to 24 May 2022. This study includes 52 eyes of 52 patients. All patients received 0.2 ml intra cameral injection of mydriatic and anesthetic after opening anterior chamber. The pupillary size was measured periodically upto the end of the surgery with caliper. Result : The mean pupil diameter was 7.6 mm±0.72 before capsulorhexis, 7.3mm± 0.78 before lens implantation and 7mm± 0.83 before sub-conjunctival injection(at the end of the surgery). In 94.2 % of the cases papillary diameter was achieved and maintained ≥6mm till the end of the surgery. Conclusion: Intra-cameral combination of tropicamide0.02%, phenylephrine 0.31% and lidocaine 1% could be a good alternative of standard regimen in SICS.
Medicine Today 2025, Vol.37 (1): 23-26
ANALISIS INTERPRETASI MAKNA PESAN MORAL DALAM FILM NGERI – NGERI SEDAP
Authors: Ryandi Dwi , Abidin Sholihul 
Published: February 2025

In this modern age of globalization, there are many alternatives or media for us and the international community to convey messages and communications, such as telephones, letter messages, and others. The development of the internet, we can access whatever we want in cyberspace, for example is movies. Film is one of the information media that contains fictional or non-fictional stories that are long and entertainment or entertaining. Movies began to flourish in the 20th century and experienced their peak in 2010 and above. Film is not only intended for commercial or entertainment purposes, but the film has the purpose of conveying an important implied message that can only be understood by people who observe it deeply and carefully. In the world of cinema it is called Easter Egg. In the world of Communication Science studies, Easter Egg is called Semiotics, which is the study of signs. Semiotics is a science that studies signs in the world of communication, one of which is used to observe the implied message contained in the film. One of the films that has a good and interesting implied message to be examined is the film that researchers will observe is "Ngeri – Ngeri Sedap".

Keywords: Communication, Film, Semiotics,
PENGARUH PENGETAHUAN PERPAJAKAN, SELF-EFFICACY DAN PERTIMBANGAN PASAR KERJA TERHADAP MINAT MAHASISWA BERKARIR SEBAGAI KONSULTAN PAJAK
Authors: Minardo Minardo Sihombing 
Published: February 2025

Profesi konsultan pajak di Kota Batam masih sedikit, hal ini disebabkan oleh rendahnya minat mahasiswa akuntansi berkarir sebagai konsultan pajak. Faktor penyebab rendahnya minat mahasiswa berkarir sebagai konsultan pajak diantaranya pengetahuan perpajakan, self-efficacy dan pertimbangan pasar kerja. Penelitian ini bertujuan untuk mengetahui apakah pengetahuan perpajakan, self-efficacy dan pertimbangan pasar kerja mempengaruhi minat mahasiswa akuntansi berkarir sebagai konsultan pajak. Metode analisis data yang digunakan dalam penelitian ini terdiri dari uji statistik deskriptif, uji kualitas data yang terdiri dari uji validitas dan uji realibilitas, uji asumsi klasik, uji regresi linear berganda, uji koefisien determinasi serta uji hipotesis yang terdiri dari uji t dan uji f. Hipotesis dalam penelitian ini menunjukkan bahwa secara parsial pengetahuan perpajakan, self-efficacy dan pertimbangan pasar kerja berpengaruh positif dan signifikan terhadap minat mahasiswa akuntansi berkarir sebagai konsultan pajak. Dan secara uji simultan pengetahuan perpajakan, self-efficacy dan pertimbangan pasar kerja berpengaruh positif dan signifikan terhadap minat mahasiswa akuntansi berkarir sebagai konsultan pajak. Uji hasil koefisien determinasi pada penelitian ini sebesar 0,397 atau sebesar 39,7% terhadap variabel minat mahasiswa akuntansi untuk berkarir sebagai konsultan pajak. Sementara itu, sebesar 60,3% sisanya dipengaruhi oleh variabel yang tidak diidentifikasi dalam penelitian ini.
EFEKTIVITAS DAN KONTRIBUSI PAJAK HOTEL, PAJAK RESTORAN, DAN PAJAK HIBURAN TERHADAPPENDAPATAN ASLI DAERAH KOTA BATAM
Authors: Suyanti Suyanti , Natalia Erni Yanti 
Published: February 2025

ABSTRACT

This research aims to determine the effectiveness and contribution of hotel tax, restaurant tax and entertainment tax to Batam City's original regional income. This research is qualitative research with a descriptive analysis approach. The population in this study is the projection and realization of the financial reports of the Batam City Regional Revenue Agency for 2019-2021 using a random sampling method based on regional location (Cluster Random Sampling) by collecting data from the official website of the Regional Revenue Information System or SIEPENDA of Batam City. From the results Research shows that the level of effectiveness of hotel, restaurant and entertainment tax collection on Batam City's PAD can be said to be effective. This is supported by Batam being a region that relies on the tourism sector as a source of PAD. The contribution of Hotel, Restaurant and Entertainment Taxes to Batam City's PAD is less effective. Based on the results of the ratio calculations that have been carried out, Batam City's hotel, restaurant and entertainment tax revenues contribute less to Batam City's PAD. This is indicated by the contribution percentage being below 10%
Mapas de arte argentino. Arquitectura histórica y modernización estatal en los proyectos de la Academia Nacional de Bellas Artes (décadas de 1930 y 1940)
Authors: García Carla Guillermina 
Published: February 2025

Este artículo se concentra en los proyectos de la Academia Nacional de Bellas Artes de Argentina (ANBA) orientados a la promoción del pasado artístico del período colonial y la relación con las políticas oficiales desarrolladas desde mediados de la década de 1930 en torno al patrimonio, el turismo y la modernización vial. La colección Documentos de Arte Argentino, principal proyecto editorial del organismo, es puesta en relación con otros recursos gráficos y con la elaboración de miradas paralelas sobre el arte y la arquitectura nacional, palpables en documentos institucionales y en fuentes hemerográficas. Se concluye que la ANBA tuvo un rol específico como organismo encargado de encarar el reconocimiento del repertorio artístico colonial del territorio argentino y de propiciar su transmisión en imágenes.
Evaluasi Rancangan UI/UX SIAKAD STMIK Rosma dengan Metode User Experience Questionnaire (UEQ)
Authors: Yudiana Yudiana , Gita Eilinafta , Darmansyah Darmansyah , B.K Felicia A. Stevanie` 
Published: February 2025

SIAKAD (Academic Information System) is a technology-based information platform used by educational institutions to manage various aspects of academic administration in an integrated manner. Rosma Academic Information System (SIAKAD) is a web-based academic information system used to manage academic administration at STMIK Rosma Karawang in an efficient and structured manner.
The research process began by identifying weaknesses in the existing website design through observations and interviews with active users. Designing the SIAKAD Rosma Karawang Website Design is a study that aims to improve the quality of the Rosma Karawang Academic Information System (SIAKAD) website. This research uses the User Experience Questionnaire (UEQ) method with six measurement scales and cooperative evaluation methods to identify user problems. The process began with surveys and interviews, followed by redesign and testing of the prototype using UEQ. Based on the data and calculation results in this research, it is shown that the SIAKAD Rosma Karawang UI/UX plan has succeeded in providing a good user experience, in accordance with the hedonic and pragmatic aspects evaluated, and can be recommended with a positive evaluation value (Above Average) .

Keywords: Website Redesign, SIAKAD, UEQ, User Experience, Web Design.
EFEKTIVITAS EKSTRAK DAUN BINAHONG SEBAGAI ANTIBAKTERI DALAM HAND SANITIZER
Authors: Ginting Ernawaty , Tambunan Ika Julianti , Dachi Kanne , Putri Nurul Maulida , Pratama Danawan Heru , Gori Iradat Novtworian , Hasibuan Munawwaroh 
Published: February 2025

Hand sanitizer adalah alat yang sangat baik untuk menghilangkan bakteri di tangan yang dapat menyebabkan penyakit seperti Staphylococcus aureus dan Escherichia coli. Dengan mengekstraknya daun binahong yang mengandung zat antibakteri flavanoid dan tanin dapat digunakan untuk membuat semprotan pembersih tangan alami. Kebaruan penelitian ini untuk mengetahui efektivitas ekstrak daun binahong sebagai antibakteri dalam Hand Sanitizer. Penelitian ini bertujuan untuk mengevaluasi efektivitas ekstrak daun binahong dalam hand sanitizer sebagai antibakteri dengan menggunakan etanol p.a. Sebagai langkah-langkahnya, dilakukan ekstraksi dan skrining daun binahong, pemilihan formula dasar, formulasi, uji antibakteri, dan evaluasi hand sanitizer. Hasil penelitian menunjukkan bahwa sediaan hand sanitizer daun sirih merah paling disukai formula F3. Hasil uji aktivitas zona hambat menunjukkan bahwa formula F3 memiliki daya hambat paling besar yaitu 18,75 mm terhadap bakteri Escherichia coli. Sebagai perbandingan, formula F1 memiliki daya hambat terbesar yaitu 15,73 mm terhadap bakteri Staphylococcus aureus. Semua pengujian pada sediaan Hand sanitizer memenuhi persyaratan berdasarkan SNI, yang berarti pengujian antibakteri dapat dikatakan “aktif”. Kesimpulannya bahwa ekstrak daun binahong efektif sebagai antibakteri dan dapat digunakan pada hand sanitizer.
EVALUASI IMPLEMENTASI RENCANA PENGAMANAN AIR MINUM (RPAM) KOTA PEKALONGAN
Authors: Sujarwo Sujarwo , Nurjazuli Nurjazuli , Raharjo Mursid 
Published: February 2025

Pemeriksaan kualitas air minum PDAM Kota Pekalongan bulan Desember 2023, total Coliform 118 CFU/100 ml sampel, Warna 10 TCU, Besi (Fe) 0,23 mg/l dan Mangan (Mn) 1,14 mg/l melebihi baku mutu Permenkes No 2 Tahun 2023. Adanya keluhan masyarakat yang menyatakan air minum yang kotor serta gangguan kesehatan (gatal-gatal) yang dilaporkan oleh salah satu Lembaga Swadaya Masyarakat (LSM), selain itu terdapat kematian 2 balita diduga karena diare serta masalah stunting naik dari 20,6% menjadi 28,2% di tahun 2023. Kebaruan penelitian ini adalah implementasi rencana pengamanan air minum. Tujuan penelitian ini untuk mengetahui resiko keamanan air minum pada aspek kualitas serta mengevaluasi implementasi rencana pengamanan air minum Kota Pekalongan. Jenis penelitian ini adalah penelitian deskriptif dengan mix method kuantitatif dan kualitatif. Sampel penelitian ini adalah 5 orang operator di lima subsistem PDAM Kota Pekalongan dan 30 titik sampel air yang diambil menggunakan metode total sampling. Penelitian ini diperkuat dengan indepth interview pada informan penelitian dan metadata hasil kegiatan surveilans kualitas air minum rumah tangga (SKAMRT) Kota Pekalongan Tahun 2024. Hasil penelitian ini ditemukan 99 resiko kejadian bahaya dengan tingkatan 4 kejadian kategori sangat tinggi, 10 kejadian kategori tinggi, 6 kejadian kategori sedang dan 79 kejadian kategori rendah. Kualitas air minum Kota Pekalongan belum dapat disebut aman menurut Permenkes No 2 Tahun 2023. Kesimpulannya yaitu Kota Pekalongan secara konsep dan upaya sudah menerapkan RPAM, tetapi belum secara dokumen, sehingga bisa dikatakan ada pada RPAM tingkat dasar.