bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiprofessional heart failure self-development framework
Authors: Forsyth Paul , Young Susan , Hughes Kirsty , James Ruby , Oxley Cheryl , Kelly Ruth , Jones Rebecca , Briggs Sarah , Mackay-Thomas Lynn , Millerick Yvonne , Simpson Maggie , Taylor Clare J , Beggs Simon , Piper Susan , Duckett Simon 
Published: January 2024

ObjectiveHeart failure remains a key public health priority across the globe. The median age of people with heart failure admitted to hospital in the UK is 81 years old. Many such patients transcend the standard interventions that are well characterised and evidenced in guidelines, into holistic aspects surrounding frailty, rehabilitation and social care. Previous published competency frameworks in heart failure have focused on the value of doctors, nurses and pharmacists. We aimed to provide an expert consensus on the minimum heart failure-specific competencies necessary for multiple different healthcare professionals, including physiotherapists, occupational therapists, dietitians and cardiac physiologists.MethodsThe document has been developed focussing on four main parts, (1) establishing a project working group of expert professionals, (2) a literature review of previously existing published curricula and competency frameworks, (3) consensus building, which included developing a structure to the framework with ongoing review of the contents to adapt and be inclusive for each specialty and (4) write up and dissemination to widen the impact of the project.ResultsThe final competency framework displays competencies across seven sections; knowledge (including subheadings on heart failure syndrome, diagnosis and clinical management); general skills; heart failure-specific skills; clinical autonomy; multidisciplinary team working; teaching and education; and research and development.ConclusionPeople with heart failure can be complex and have needs that require input from a broad range of specialties. This publication focuses on the vital impact of wider multidisciplinary groups and should help define the generic core heart failure-specific competencies needed to support future pipelines of professionals, who regularly interact with and deliver care for patients with heart failure.
A review of the Carboniferous shale gas potential of northern England: a data-based analysis of why it won't work
Authors: Fraser Alastair J. , Lodhia Bhavik H. , Sims Michael J. E. 
Published: January 2024

Abstract
The recent shale gas revolution originated in the USA in the late 1990s with the exploration of the Carboniferous Barnett Shale in Texas. Success in a number of additional basins in North America, such as the Marcellus, Eagle Ford and Bakken basins, stimulated a search for similar opportunities elsewhere around the world. Among the shales and basins targeted by industry was the Carboniferous Bowland Shale (and equivalents) in northern England. The initial premise that the Barnett Shale represented an excellent analogue for the Bowland Shale led to over-optimistic reserve estimates that have since been shown to be largely incorrect. On the basis of visual inspection of wellbore cores, the Carboniferous Barnett and Bowland shales appear to be very similar. Unfortunately, it is there that the similarity ends. Research carried out for the UK Unconventional Hydrocarbons project has highlighted important differences adversely impacting prospectivity. These can be summarized as basin type/continuity and structural complexity. The total organic carbon, maturity, mineralogy and thickness of the Bowland Shale and equivalents are broadly similar to the successful US examples. Our conclusion is that the Bowland Shale in the UK does not represent a technically significant resource, and in hindsight did not merit the considerable industry and media attention that has been associated with it. One key learning is that fundamental research based on heritage data and modern analytical and modelling techniques should have preceded drilling and fracking operations in northern England.
EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth
Authors: Kuhlmann-Hogan Alexandra , Cordes Thekla , Xu Ziyan , Kuna Ramya S. , Traina Kacie A. , Robles-Oteíza Camila , Ayeni Deborah , Kwong Elizabeth M. , Levy Stellar , Globig Anna-Maria , Nobari Matthew M. , Cheng George Z. , Leibel Sandra L. , Homer Robert J. , Shaw Reuben J. , Metallo Christian M. , Politi Katerina , Kaech Susan M. 
Published: January 2024

Abstract

The limited efficacy of currently approved immunotherapies in EGFR-driven lung adenocarcinoma (LUAD) underscores the need to better understand alternative mechanisms governing local immunosuppression to fuel novel therapies. Elevated surfactant and GM-CSF secretion from the transformed epithelium induces tumor-associated alveolar macrophage (TA-AM) proliferation, which supports tumor growth by rewiring inflammatory functions and lipid metabolism. TA-AM properties are driven by increased GM-CSF–PPARγ signaling and inhibition of airway GM-CSF or PPARγ in TA-AMs suppresses cholesterol efflux to tumor cells, which impairs EGFR phosphorylation and restrains LUAD progression. In the absence of TA-AM metabolic support, LUAD cells compensate by increasing cholesterol synthesis, and blocking PPARγ in TA-AMs simultaneous with statin therapy further suppresses tumor progression and increases proinflammatory immune responses. These results reveal new therapeutic combinations for immunotherapy-resistant EGFR-mutant LUADs and demonstrate how cancer cells can metabolically co-opt TA-AMs through GM-CSF–PPARγ signaling to provide nutrients that promote oncogenic signaling and growth.

Significance:
Alternate strategies harnessing anticancer innate immunity are required for lung cancers with poor response rates to T cell–based immunotherapies. This study identifies a targetable, mutually supportive, metabolic relationship between macrophages and transformed epithelium, which is exploited by tumors to obtain metabolic and immunologic support to sustain proliferation and oncogenic signaling.
This article is featured in Selected Articles from This Issue, p. 384
Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer
Authors: Suda Kazuto , Okabe Atsushi , Matsuo Junichi , Chuang Linda Shyue Huey , Li Ying , Jangphattananont Nawaphat , Mon Naing Naing , Myint Khine Nyein , Yamamura Akihiro , So Jimmy Bok-Yan , Voon Dominic Chih-Cheng , Yang Henry , Yeoh Khay Guan , Kaneda Atsushi , Ito Yoshiaki 
Published: January 2024

Abstract

Gastric cancer metastasis is a major cause of mortality worldwide. Inhibition of RUNX3 in gastric cancer cell lines reduced migration, invasion, and anchorage-independent growth in vitro. Following splenic inoculation, CRISPR-mediated RUNX3-knockout HGC-27 cells show suppression of xenograft growth and liver metastasis. We interrogated the potential of RUNX3 as a metastasis driver in gastric cancer by profiling its target genes. Transcriptomic analysis revealed strong involvement of RUNX3 in the regulation of multiple developmental pathways, consistent with the notion that Runt domain transcription factor (RUNX) family genes are master regulators of development. RUNX3 promoted “cell migration” and “extracellular matrix” programs, which are necessary for metastasis. Of note, we found pro-metastatic genes WNT5A, CD44, and VIM among the top differentially expressed genes in RUNX3 knockout versus control cells. Chromatin immunoprecipitation sequencing and HiChIP analyses revealed that RUNX3 bound to the enhancers and promoters of these genes, suggesting that they are under direct transcriptional control by RUNX3. We show that RUNX3 promoted metastasis in part through its upregulation of WNT5A to promote migration, invasion, and anchorage-independent growth in various malignancies. Our study therefore reveals the RUNX3-WNT5A axis as a key targetable mechanism for gastric cancer metastasis.

Significance:
Subversion of RUNX3 developmental gene targets to metastasis program indicates the oncogenic nature of inappropriate RUNX3 regulation in gastric cancer.
The Pitfalls of Defining Hallucination
Authors: Deemter Kees van 
Published: January 2024

Abstract
Despite impressive advances in Natural Language Generation (NLG) and Large Language Models (LLMs), researchers are still unclear about important aspects of NLG evaluation. To substantiate this claim, I examine current classifications of hallucination and omission in data-text NLG, and I propose a logic-based synthesis of these classfications. I conclude by highlighting some remaining limitations of all current thinking about hallucination and by discussing implications for LLMs.
Combining multimodal connectivity information improves modelling of pathology spread in Alzheimer’s disease
Authors: Thompson Elinor , Schroder Anna , He Tiantian , Shand Cameron , Soskic Sonja , Oxtoby Neil P. , Barkhof Frederik , Alexander Daniel C. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: January 2024

Abstract
Cortical atrophy and aggregates of misfolded tau proteins are key hallmarks of Alzheimer’s disease. Computational models that simulate the propagation of pathogens between connected brain regions have been used to elucidate mechanistic information about the spread of these disease biomarkers, such as disease epicentres and spreading rates. However, the connectomes that are used as substrates for these models are known to contain modality-specific false positive and false negative connections, influenced by the biases inherent to the different methods for estimating connections in the brain. In this work, we compare five types of connectomes for modelling both tau and atrophy patterns with the network diffusion model, which are validated against tau PET and structural MRI data from individuals with either mild cognitive impairment or dementia. We then test the hypothesis that a joint connectome, with combined information from different modalities, provides an improved substrate for the model. We find that a combination of multimodal information helps the model to capture observed patterns of tau deposition and atrophy better than any single modality. This is validated with data from independent datasets. Overall, our findings suggest that combining connectivity measures into a single connectome can mitigate some of the biases inherent to each modality and facilitate more accurate models of pathology spread, thus aiding our ability to understand disease mechanisms, and providing insight into the complementary information contained in different measures of brain connectivity
The Nature of Time in Relativistic Operational Reality
Authors: Aerts Diederik , Sassoli de Bianchi Massimiliano 
Published: January 2024

Abstract
In their recent articles Gruber, Block and Montemayor (2022: Front. Psychol., 13, 718505) and Buonomano and Rovelli (2022: arXiv:2110.01976) discuss the differences between time in physics and psychology. With the aim of commenting on their views, we first outline a few general aspects of relativity theory, and some of the core elements of our approach, referring the reader to Aerts (1996: Found. Phys., 26, 1627–1644; 2018: Found. Sci., 23, 511–547), Aerts and Aerts (2004: in A. C. Elitzur, S. Dolev and N. Kolenda (Eds), Quo Vadis Quantum Mechanics? Possible Developments in Quantum Theory in the 21st Century, pp. 153–207) and Aerts and Sassoli de Bianchi (2023: arXiv:2307.04764) for more details. In our approach, the ability of the experimenter to freely choose to perform or not to perform an experiment is explicitly considered and applied to the typical twin-paradox situation. This leads to the definition of a four-dimensional spacetime reality for each observer, a personal block universe. This is compatible with the existence of a local contextual present for each observer, travelling on their worldline, from their personal past to their personal future. Global spacetime becomes, as a corollary, a structure full of measurement-induced bifurcations towards the future, thus fundamentally nondeterministic. We analyze and highlight how this nondeterministic global reality is the one that follows from an operational approach inspired by quantum foundations, opening a way for an integration of relativity and quantum.
Thinking Backwards about Time
Authors: Sheehan Daniel P. 
Published: January 2024

Abstract
The concept of time in physics and its connection to consciousness are becoming increasingly problematic. A missing ingredient to both could be retrocausation — the temporal inverse of everyday causation — in which the future influences the past. Apparent evidence for it is in the phenomenon of precognition. Thus far, psychology and physics have assiduously avoided incorporating precognition into their paradigms, even though experimental evidence for it is substantial. Among many noteworthy studies, the Graff–Cyrus experiment is explicated here as an outstanding example of the phenomenon. It is hoped that consciousness, retrocausation, and precognition can be accommodated within the current paradigm of physics, helping bridge the gap to psychology.
Anatomic Relationship Between the Head of the Middle Turbinate and First Olfactory Filum: A Radiographic Assessment
Authors: Obermeyer Isaac P. , Nguyen Cecilia H. , Yoo Frederick , Garg Rohit , Kuan Edward C. 
Published: January 2024

Background: The endoscopic modified Lothrop procedure (EMLP) has become a frequently utilized procedure in rhinologic surgery. One of the most serious complications of the procedure is cerebrospinal fluid leak, which may occur due to lack of recognition of the anterior skull base in the region of the first olfactory filum (FOF), or direct injury to the FOF itself. Objectives: To evaluate the position of the head of the middle turbinate (MT) relative to the FOF, which is an important landmark in the EMLP. Methods: A series of previously obtained patient computed tomography scans of the sinus were reviewed. A reproducible process was implemented to obtain the measurements. First, the FOF was identified on an axial series. Using a localization feature of the radiographic software, this anteroposterior (AP) position could be visualized in a coronal plane. Subsequently, the MT was viewed in a sagittal plane, where a measurement between the head of the MT and the AP position of the FOF could be performed. Results: The AP distance between the head of the MT and the FOF was measured in 92 patients. The head of the MT was either at or anterior to the FOF in all measured subjects. The mean anterior distance of the head of the MT to FOF was 3.6 mm (±2.4 mm) on the right, and 3.8 mm (±2.2 mm) on the left. The range in AP distance was 0 to 12 mm. There was no significant difference in AP distance between the head of the MT and FOF based on gender ( P = .413) or diagnosis ( P = .254). Conclusions: In our study, the head of the MT was reliably at or anterior to the FOF in all subjects, suggesting its utility as a fixed landmark in endoscopic sinus surgery, particularly in the EMLP. Level of Evidence: N/A.
Unsaturated out-of-plane permeability measured with three-dimensional flow monitoring by etched optical fiber sensors
Authors: Liu Xiao , Sousa Pedro , Pfeiffer Helge , Lomov Stepan V. , Ivens Jan , Qing Xinlin 
Published: January 2024

In our work, the three-dimensional flow in stacks of biaxial E-glass fiber non-crimp fabrics (NCF) and unidirectional carbon fiber layers was monitored by the etched optical fiber sensors embedded inside the fabric stack. The influence of embedding sensors with a diameter of 200 µm on the flow was experimentally illustrated and discussed. The out-of-plane permeability of the two fabric materials was estimated with a radial infusion model using the in-plane permeability values as the prior knowledge. The assumed radius of the semi-ellipsoidal flow was derived and showed a good agreement with the results obtained by the best fit of the exact solution, which provides an approximate solution that simplifies the calculation process. The asymptotic form and the modified semi-ellipsoidal inlet radius method for the case of a non-negligible radius of injection tube compared to the fabric sample thickness were verified. The uncertainties related to the unknown flow pattern near the inlet were also demonstrated. The presented results facilitate the further development and standardization of out-of-plane permeability measurement methods with embedded sensors.
Association of metformin use with abdominal aortic aneurysm: A systematic review and meta-analysis
Authors: Dewangga Raditya , Winston Kevin , Ilhami Lazuardi Gayu , Indriani Suci , Siddiq Taofan , Adiarto Suko 
Published: January 2024

Background Abdominal aortic aneurysm (AAA) is a cardiovascular disease characterized by a high mortality rate when ruptured. Some studies suggest a potential inverse correlation between AAA and diabetes patients, especially those undergoing metformin treatment. However, this relationship remains unclear. This paper offers a systematic review and meta-analysis with the objective of clarifying the influence of metformin on AAA. Methods A search for relevant articles was performed across multiple databases including PubMed, ScienceDirect, Cochrane and Scopus. The focus was on studies that examined the comparative effects of metformin and non-metformin treatments on AAA patients. Data from appropriate studies were consolidated to estimate the effects. Our study encompassed 11 articles, comprising 13 cohorts that compared metformin ( n = 32,250) with a control group ( n = 116,339). Results The random effects meta-analysis revealed that metformin was associated with a slower growth rate (weighted mean difference (WMD) −0.86 mm; 95% CI: −1.21 to −0.52; p < 0.01; I2: 81.4%) and fewer AAA-related events (OR: 0.54; 95% CI: 0.34 to 0.86; p = 0.01; I2: 60.9%). The findings suggest that metformin may be linked to a reduced risk of aortic aneurysm. A meta-regression analysis indicated that the association between metformin and AAA growth was significantly influenced by male gender ( p = 0.027), but not by age ( p = 0.801), hypertension ( p = 0.256), DM ( p = 0.689), smoking history ( p = 0.786), use of lipid-lowering agents ( p = 0.715), or baseline diameter ( p = 0.291). Conclusion These results hint at a potential role for metformin in limiting annual AAA growth, AAA-related events, and the risk of AAA.
Multiple thromboses, including intracardiac thrombi, accompanied by HIT during ECMO successfully treated with NOACs: A case report
Authors: Yun Won-Sik , Kim Sanghyo , Jung Lae-Young 
Published: January 2024

Introduction Unfractionated heparin remains the mainstay of anticoagulation therapy during extracorporeal membrane oxygenation (ECMO) maintenance. However, its continued use in clinical practice exposes patients to the risk of developing heparin-induced thrombocytopenia (HIT). Case Report A 50-year-old male was diagnosed with multiple thromboses, including an intracardiac thrombi, accompanied by HIT during ECMO after cardiogenic shock related to acute myocardial infarction. The patient was successfully treated with new oral anticoagulants (NOAC), without significant complications. Discussion HIT during ECMO resulting in multiple thromboses is rare. To our knowledge, this is the first reported case of NOAC use in this context. Conclusion Although thrombocytopenia and thrombosis can occur for various reasons during ECMO maintenance, it is important to consider HIT as a potential cause. NOACs can be considered as a therapeutic option.
Older adults in psychedelic-assisted therapy trials: A systematic review
Authors: Bouchet Lisa , Sager Zachary , Yrondi Antoine , Nigam Kabir B , Anderson Brian T , Ross Stephen , Petridis Petros D , Beaussant Yvan 
Published: January 2024

Background: Growing clinical interest in psychedelic-assisted therapies has led to a second wave of research involving psilocybin, lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA) and other substances. Data suggests that these compounds have the potential to treat mental health conditions that are especially prevalent in older adults such as depression, anxiety, existential distress, and posttraumatic stress disorder. Aims: The goal of this study was to quantify the prevalence of older adults enrolled in psychedelic clinical trials and explore safety data in this population. Methods: A systematic review was conducted following the 2020 PRISMA guidelines. Search criteria included all trials published in English using psychedelic substances to treat psychiatric conditions, including addiction as well as existential distress related to serious illness. Articles were identified from literature searches on PubMed, EBSCO, and EMBASE. Results: 4376 manuscripts were identified, of which 505 qualified for further review, with 36 eventually meeting eligibility criteria. Of the 1400 patients enrolled in the 36 studies, only 19 were identified as 65 or older, representing less than 1.4% of all trial participants. For 10 of these 19 older adults, detailed safety data was obtained. No serious adverse events (AEs) occurred in any older adults and only transient mild-to-moderate AEs related to anxiety, gastrointestinal upset, and hypertension were reported during the psychedelic dosing sessions. Conclusions: While existing data in older adults is limited, it suggests that psychedelic-assisted psychotherapy can be safe and well tolerated in older adults. Therefore, psychedelic-assisted psychotherapy should be more rigorously investigated for the treatment of psychiatric conditions in this population.