bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key factors for effective implementation of healthcare workers support interventions after patient safety incidents in health organisations: a scoping review
Authors: Guerra-Paiva Sofia , Lobão Maria João , Simões Diogo Godinho , Fernandes Joana , Donato Helena , Carrillo Irene , Mira José Joaquín , Sousa Paulo 
Published: December 2023

ObjectivesThis study aims to map and frame the main factors present in support interventions successfully implemented in health organisations in order to provide timely and adequate response to healthcare workers (HCWs) after patient safety incidents (PSIs).DesignScoping review guided by the six-stage approach proposed by Arksey and O’Malley and by PRISMA-ScR.Data sourcesCINAHL, Cochrane Library, Embase, Epistemonikos, PsycINFO, PubMed, SciELO Citation Index, Scopus, Web of Science Core Collection, reference lists of the eligible articles, websites and a consultation group.Eligibility criteria for selecting studiesEmpirical studies (original articles) were prioritised. We used the Mixed Methods Appraisal Tool Version 2018 to conduct a quality assessment of the eligible studies.Data extraction and synthesisA total of 9766 records were retrieved (last update in November 2022). We assessed 156 articles for eligibility in the full-text screening. Of these, 29 articles met the eligibility criteria. The articles were independently screened by two authors. In the case of disagreement, a third author was involved. The collected data were organised according to the Organisational factors, People, Environment, Recommendations from other Audies, Attributes of the support interventions. We used EndNote to import articles from the databases and Rayyan to support the screening of titles and abstracts.ResultsThe existence of an organisational culture based on principles of trust and non-judgement, multidisciplinary action, leadership engagement and strong dissemination of the support programmes’ were crucial factors for their effective implementation. Training should be provided for peer supporters and leaders to facilitate the response to HCWs’ needs. Regular communication among the implementation team, allocation of protected time, funding and continuous monitoring are useful elements to the sustainability of the programmes.ConclusionHCWs’ well-being depends on an adequate implementation of a complex group of interrelated factors to support them after PSIs.
Social isolation, loneliness and subsequent risk of major adverse cardiovascular events among individuals with type 2 diabetes mellitus
Authors: Liang Yannis Yan , Chen Yilin , Feng Hongliang , Xue Huachen , Nie Yu , Ai Qi-Yong H , Ma Jiacheng , Yang Lulu , Zhang Jihui , Ai Sizhi 
Published: December 2023

BackgroundIndividuals with type 2 diabetes mellitus (T2DM) are more vulnerable to social disconnection compared with the general population; however, there are few relevant studies investigating this issue.AimsTo investigate whether social isolation or loneliness may be associated with subsequent risk of developing major adverse cardiovascular events, whether these associations vary according to fatal and non-fatal outcomes and how behavioural, psychological and physiological factors mediate these associations.MethodsThis longitudinal analysis included data from 19 360 individuals with T2DM at baseline (2006–2010) from the UK Biobank. Social isolation and loneliness were measured using self-report questionnaires. The study outcomes included the first events of myocardial infarction (MI) or stroke (n=2273) and all-cause (n=2820) or cardiovascular disease-related mortality through linked hospital data or death registries.ResultsOver a median follow-up of 12.4 years (interquartile range (IQR): 11.6–13.3 years), participants who were more socially isolated (most social isolation vs least social isolation) experienced increased risks for all-cause (hazard ratio (HR) : 1.33, 95% confidence interval (CI): 1.19 to 1.47) and cardiovascular disease (HR: 1.36, 95% CI: 1.17 to 1.59) mortality but not first MI or stroke. Loneliness (yes vs no) was associated with a greater risk for a composite of incident MI or stroke (HR: 1.37, 95% CI: 1.19 to 1.57) but not mortality. Social isolation was associated with fatal MI and stroke, whereas loneliness was associated with non-fatal MI and stroke. The significant associations of social isolation and loneliness with outcomes were mainly mediated by behavioural factors (mediating proportion: 17.8%–28.2% and 17.6%–17.8%, respectively).ConclusionsAmong individuals with T2DM, social isolation and loneliness are associated with a greater risk of developing major adverse cardiovascular events, with differences in both risks stratified according to fatal and non-fatal events and underlying mediating factors.
Are JAKis more effective among elderly patients with RA, smokers and those with higher cardiovascular risk? A comparative effectiveness study of b/tsDMARDs in Sweden
Authors: Bower Hannah , Frisell Thomas , di Giuseppe Daniela , Delcoigne Benedicte , Lindström Ulf , Turesson Carl , Chatzidionysiou Katerina , Lindqvist Elisabet , Knight Ann , Forsblad-d'Elia Helena , Askling Johan 
Published: December 2023

ObjectivesTo investigate whether the relative effectiveness of janus kinase inhibitors (JAKis) versus tumour necrosis factor inhibitors (TNFi) or other biological disease-modifying antirheumatic drugs in rheumatoid arthritis differ by the presence or absence of risk factors for cardiovascular (CV) disease, age, sex and smoking.MethodsThrough Swedish registers, we identified 13 493 individuals with 3166 JAKi, 5575 non-TNFi and 11 286 TNFi treatment initiations 2016–2022. All lines of therapy were included, with the majority in second line or higher. Treatment response was defined as the proportion reaching European Alliance of Associations for Rheumatology (EULAR) good response and Clinical Disease Activity Index (CDAI) remission, respectively, within 6 months. Crude percentage point differences in these proportions (JAKis, and non-TNFis, vs TNFis) overall and by risk factors were observed, and adjusted for confounders using linear regression models. Predicted probabilities of response and remission were estimated from adjusted Poisson models, and presented across CV risk and age.ResultsOverall, adjusted percentage point differences indicated higher response (+5.0%, 95% CI 2.2% to 7.9%) and remission (+5.8%, 95% CI 3.2% to 8.5%) with JAKis versus TNFis. The adjusted percentage point differences for response in those above 65, at elevated CV risk, and smokers were +5.9% (95% CI 2.7% to 9.0%), +8.3% (95% CI 5.3% to 11.4%) and +6.0% (95% CI 3.3% to 8.7%), respectively. The corresponding estimates for remission were +8.0% (95% CI 5.3% to 10.8%), +5.6% (95% CI 3.0% to 8.2%) and +7.6% (95% CI 5.5% to 9.7%).ConclusionsAs used in clinical practice, response and remission at 6 months with JAKis are higher than with TNFi. Among patients with risk factors of concern, effectiveness is similar or numerically further increased. For individualised benefit-to-risk ratios to guide treatment choice, safety and effectiveness in specific patient segments should be considered.
Treatment and monitoring of SAPHO syndrome: a systematic review
Authors: Li Sophie W S , Roberts Eve , Hedrich Christian 
Published: December 2023

Background and objectivesSynovitis acne pustulosis hyperostosis osteitis (SAPHO) is a rare heterogeneous disease of unknown aetiopathology. Externally validated and internationally agreed diagnostic criteria or outcomes and, as a result, prospective randomised controlled trials in SAPHO are absent. Consequently, there is no agreed treatment standard. This study aimed to systematically collate and discuss treatment options in SAPHO.MethodsFollowing ‘Preferred Reporting Items for Systematic Reviews and Meta-Analyses’ guidance, a systematic literature search was conducted using PubMed, Scopus and Web of Science databases. Prospective clinical studies and retrospective case collections discussing management and outcomes in SAPHO involving five or more participants were included. Articles not published in English, studies not reporting defined outcomes, and studies solely relying on patient-reported outcomes were excluded.ResultsA total of 28 studies (20 observational, 8 open-label clinical studies) reporting 796 patients of predominantly European ethnicity were included. Reported therapies varied greatly, with many centres using multiple treatments in parallel. Most patients (37.1%) received non-steroidal anti-inflammatory drugs alone or in combination. Bisphosphonates (22.1%), conventional (21.7%) and biological (11.3%) disease-modifying antirheumatic drugs were the next most frequently reported treatments. Reported outcomes varied and delivered mixed results, which complicates comparisons. Bisphosphonates demonstrated the most consistent improvement of osteoarticular symptoms and were associated with transient influenza-like symptoms. Paradoxical skin reactions were reported in patients treated with TNF inhibitors, but no serious adverse events were recorded. Most treatments had limited or mixed effects on cutaneous involvement. A recent study investigating the Janus kinase inhibitor tofacitinib delivered promising results in relation to skin and nail involvement.ConclusionsNo single currently available treatment option sufficiently addresses all SAPHO-associated symptoms. Variable, sometimes descriptive outcomes and the use of treatment combinations complicate conclusions and treatment recommendations. Randomised clinical trials are necessary to generate reliable evidence.
The omega-reducibility of pseudovarieties of ordered monoids representing low levels of concatenation hierarchies
Authors: Volaříková Jana 
Published: December 2023

We deal with the question of the [Formula: see text]-reducibility of pseudovarieties of ordered monoids corresponding to levels of concatenation hierarchies of regular languages. A pseudovariety of ordered monoids [Formula: see text] is called [Formula: see text]-reducible if, given a finite ordered monoid M, for every inequality of pseudowords that is valid in [Formula: see text], there exists an inequality of [Formula: see text]-words that is also valid in [Formula: see text] and has the same “imprint” in M. Place and Zeitoun have recently proven the decidability of the membership problem for levels [Formula: see text], 1, [Formula: see text] and [Formula: see text] of concatenation hierarchies with level 0 being a finite Boolean algebra of regular languages closed under quotients. The solutions of these membership problems have been found by considering a more general problem of separation of regular languages and its further generalization — a problem of covering. Following the results of Place and Zeitoun, we prove that, for every concatenation hierarchy with level 0 being represented by a locally finite pseudovariety of monoids, the pseudovarieties corresponding to levels [Formula: see text] and [Formula: see text] are [Formula: see text]-reducible. As a corollary of these results, we obtain that, for every concatenation hierarchy with level 0 being represented by a locally finite pseudovariety of monoids, the pseudovarieties corresponding to levels [Formula: see text] and [Formula: see text] are definable by [Formula: see text]-inequalities. Furthermore, in the special case of the Straubing–Thérien hierarchy, using a characterization theorem for level 2 by Place and Zeitoun, we obtain that the level 2 is definable by [Formula: see text]-identities.
Enhancing the fidelity of controlled cyclic teleportation via quantum weak measurement techniques to combat the decoherence due to amplitude damping
Authors: Singh Deepak , Kumar Sanjeev 
Published: December 2023

This study focuses on the impact of amplitude-damping noise, which diminishes the fidelity of the teleported quantum state on an existing cyclic quantum teleportation scheme [V. Verma, D. Yadav and D. K. Mishra, Opt. Quantum Electron. 53 (2021) 1]. The CQT scheme involves three participants performing a cyclic teleportation along with a controller to supervise the protocol. We also propose weak measurement and reversal measurement operations as potential solutions to combat the noise-induced decoherence and improve the fidelity of the existing CQT scheme. The simulation results showcase the improvements achieved in the fidelity calculation when implementing the potential solutions. The findings hold immense potential for quantum information communications in practical situations.
Kawi-samaya: Towards an Ecocritical Theory of Kakawin literature
Authors: Chen-Kleinman Danielle , Keerthi Naresh 
Published: December 2023

Abstract
There is not much by way of literary theory for kakawin—the classical literature of Java. This article proposes a semiotic model for the study of belletristic texts in Old Javanese: one that is based on the study of literary commonplaces that we have called kawi-samayas. Given the way the mental world of kakawin is deeply enmeshed with the external, natural world, we focus on the ecoliterary treatment of Kapat, the fourth month in the Javanese calendar. By studying the poetic elaboration of motifs related to Kapat in several kakawin texts, beginning with Monaguṇa’s Sumanasāntaka, we discuss the notions of poetic memory and literary tradition. The idea of poetic memory also helps in chalking out the active role of literary audiences in shaping the allusive and reflexive aesthetics of kakawin literature.
Laparoscopic pancreaticoduodenectomy versus open pancreaticoduodenectomy for carcinoma of the ampulla of Vater in a medium-volume center: a propensity score matching analysis
Authors: Liu Chenming , Liu Yuxing , Dong Jiaming , Chai Yingjie , Tang Haijun 
Published: December 2023

Objective To compare the efficacy of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) in a medium-volume medical center. Methods Data for patients who underwent OPD or LPD for carcinoma of the ampulla of Vater (VPC) between January 2017 and June 2022 were acquired retrospectively. Propensity score-matching (PSM) analysis was performed to balance the baseline characteristics between the groups. The primary outcome was disease-free survival (DFS). Cox regression analysis was used to explore the independent risk factors for DFS. Results A total of 124 patients with pathologically diagnosed VPC were included. After 1:1 matching, there were 23 cases each in the OPD and LPD groups. Kaplan–Meier survival analyses showed that the median DFS in the OPD and LPD groups was identical (16.0 months vs 16.0 months, respectively). Multivariate Cox regression analysis showed that low levels of alkaline phosphatase and γ-glutamyl transpeptidase, positive surgical margin, and lymph node enlargement were independent risk factors for DFS. Conclusion LPD in medium-volume centers with acceptable technical conditions may approach or even achieve the efficacy of LPD in large-volume centers.
Cytisine as a smoking cessation aid: Preliminary observations with a modified therapeutic scheme in real life
Authors: Pozzi Paolo , Boffi Roberto , Veronese Chiara , Trussardo Sara , Valsecchi Camilla , Sabia Federica , Pastorino Ugo , Apolone Giovanni , Cardani Elisa , Tarantini Francesco , Munarini Elena 
Published: December 2023

Introduction: Cigarette smoke accounts for over 90,000 deaths each year in Italy. Tobacco dependence treatment guidelines suggest adopting an integrated pharmacological-behavioral model of intervention. Cytisine is a partial agonist of nicotinic receptors. Trials conducted to date have demonstrated its good efficacy in promoting smoking cessation. The cytisine scheme of treatment consists of 25 days of treatment. A 40-day regimen, with an escalating dose and an extended duration of the treatment, has been in use in many anti-smoking centers in Italy for several years, but to date there are no reports on the use of cytisine with this scheme. Methods: A retrospective, real-life, observational study was conducted between January 2016 and September 2022. The 300 patients who had received at least one dose of study medication were selected. Continuous variables were compared by the Wilcoxon-Mann–Whitney test. Univariate and multivariate logistic regression models were implemented for self-reported seven-day point prevalence for abstinence at three, six and 12 months. Results: The median age of the patients was 59 years, 57% were women. The median smoking exposure was 33.8 pack-years. Self-reported smoking abstinence at three, six and 12 months was 68.7%, 56.3% and 47.3% respectively. 84% completed the cytisine treatment, 31.3% reported adverse events and in 8.3% these led to dropping out of the treatment. Conclusion: Cytisine, administered with a novel therapeutic scheme in the real-life setting of a specialized anti-smoking center, significantly promotes smoking abstinence. However, more studies are needed to assess the tolerability and efficacy of this new regimen.
Research trends in testosterone deficiency and management: A bibliometric analysis approach to quality improvement in urology resident education
Authors: Mahmoud Rami H , Cardoso Osmay , Colombo Alyssa , Constantinescu David , Deebel Nicholas A 
Published: December 2023

Introduction: Previous work has demonstrated a deficiency in urology resident education when it comes to andrology and male infertility. We analyzed the top 100 most frequently cited and influential articles published on testosterone deficiency and its associated therapy, allowing trainees and clinicians to review and understand the characteristics of impactful literature for self-directed learning purposes. Methods: The ISI Web of Knowledge database was used to find articles on testosterone deficiency, hypogonadism, and replacement therapies. Relevant, peer-reviewed, English articles were included. Article details, including title, citation count, publication year, and more, were gathered. Articles were classified based on content (e.g. clinical outcomes, anatomy, and trends) using defined criteria. Results: The top 300 most cited were reviewed with 100 included. The most cited article had 774 citations, averaging 234 in the top 100. Publication years had peaks in 2003–2004 and 2006–2007. The US led in publications (56), followed by England (16), Germany (14), and Italy (13). Common affiliations included US Department of Veteran Affairs, Veterans Health Administration, RIC Research Education Clinical Center, and University of California System. Articles were categorized as LOE 2 (47), LOE 1 (22), and LOE 5 (21). Articles focused on clinical outcomes (71.7%), anatomy/biomechanics/physiology (14.1%), clinical guidelines (8.1%), and screening (4%). The “ Journal of Clinical Endocrinology & Metabolism” published 26 of the top 100 cited articles. Conclusions: This analysis highlights influential articles regarding testosterone deficiency and management. The discussed articles have significant clinical and therapeutic implications for the practicing urologist which may bolster deficits in current resident education.
Latent profiles of nurses’ moral resilience and compassion fatigue
Authors: Chen Xuelei , Zhang Yanju , Zheng Ruishuang , Hong Wei , Zhang Jingping 
Published: December 2023

BackgroundCompassion fatigue is often associated with moral distress in the nursing practice among registered nurses. Moral resilience is an important ability to maintain, restore, or promote their physical and mental health in response to ethical dilemmas in nursing. Moral resilience can be utilized as a potential solution to aid registered nurses in effectively managing compassion fatigue.AimTo identify latent profiles of moral resilience among registered nurses and to explore the relationships of these profiles with compassion fatigue.Research designFrom August 2022 to December 2022, 569 nurses were recruited in two general hospitals, in China. A Rushton Moral Resilience Scale and the Chinese version of Compassion Fatigue—Short Scale were given to the participants. A latent profile analysis was conducted to explore moral resilience latent profiles. Predictors of profiles membership was evaluated using multinomial logistic regression analysis, and the compassion fatigue scores of each latent profile were compared using a one-way analysis of variance.Ethical considerationsWe obtained ethical approval from the Institution Review Board of Xiangya School of Nursing, Central South University (IRB No. E202293, approved 15/July/2022).ResultsA four-profile moral resilience model best fit the data. Different levels and shapes differentiated the four profiles: high moral resilience (28.7%), moderate moral resilience (52.3%), low responses and high efficacy (16.2%), and low moral resilience (2.8%). Nurses with bachelor’s degrees were more likely to belong to the high moral resilience ( OR = 0.118, p = .038) and moderate moral resilience ( OR = 0.248, p = .045); Nurses who were divorced or separated ( OR = 11.746, p = .025) and very dissatisfied with their work ( OR = 0.001, p = .049) were more probably belonging to low moral resilience. Nurses who had received ethical training in the hospital were more likely involved in high moral resilience ( OR = 5.129, p = .003) and low responses and high efficacy ( OR = 5.129, p = .003). In each profile of moral resilience, compassion fatigue was experienced differently by the participants ( F = 13.05, p < .001).ConclusionsDeveloping and implementing interventions tailored to each nurse’s moral resilience profile would maximize interventions’ effectiveness and reduce nurses’ compassion fatigue.
Ocular features in myopic eyes with longer horizontal ciliary sulcus diameters for intended implantable collamer lens surgery
Authors: Chen Xi , Wan Linxi , Ye Yiming , Yao Huan , Cui Zedu , Huang Yuke , Wang Xiao , Hou Xiangtao , Luo Qian , Qiu Jin , Li Yan , Zhuang Jing , Yu Keming 
Published: December 2023

Purpose: To assess the ocular anterior segment characteristics in myopic eyes intended for ICL surgery with horizontal ciliary sulcus-to-sulcus (STS) diameters being greater than vertical STS diameters. Methods: This retrospective, comparative case study included 1230 eyes of patients who underwent ICL implantation for the treatment of myopia or myopic astigmatism at the Zhongshan Ophthalmic Center from September 2020 to November 2021. The myopic eyes were divided into two groups according to the relatively long diameter of the ciliary sulcus. General parameters and anterior chamber parameters were compared between the two groups. Results: 1230 eyes of 694 patients were included. The proportion of myopic eyes with longer horizontal STS diameters was 4.63%. Horizontal STS distances exceeding vertical meridians in these eyes were mainly attributed to the shortening of vertical STS distances (horizontal STS: P = 0.112; vertical STS: P < 0.001). Eyes with longer horizontal meridians of the ciliary sulcus displayed larger steep keratometry value ( P = 0.001), larger corneal volume ( P = 0.002), larger corneal astigmatism ( P < 0.001), larger ocular residual astigmatism ( P = 0.017), worse visual acuity (logMAR UDVA: P = 0.021; logMAR CDVA: P = 0.001), and more iridociliary cysts ( P = 0.017) compared to eyes with vertically oval shapes. Conclusion: Myopic eyes with longer horizontal STS diameters are commonly accompanied by a change in corneal morphology and more iridociliary cysts. The anatomical features of the ciliary sulcus should be given sufficient consideration to ICL size and placement selection, contributing to more personalized and precise surgery.