bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive Reuse Potential of Cultural Heritage: The Case of Istanbul Drapers’ Bazaar
Authors: Bayraktaroğlu Begüm , Erkartal Pınar Öktem 
Published: October 2023

Abstract
The main objective of the study is to investigate the possibilities of adaptive reuse for the protection of cultural heritage buildings. It aims to set Istanbul Drapers’ Bazaar (IDB), as an example of the buildings with similar characteristics and importance and for the cities hosting those structures upon an application of the AdaptSTAR method, which was developed to assess the conversion potential of buildings. Focused on a bazaar complex, an important example of modern architectural heritage, the present study contributes to the healthy transfer of the building to future generations and the improvement of its international recognition by investigating it in the context of convertibility. In this study, a mixed-mode research methodology including a two-stage approach was adopted. The first stage includes detailed qualitative interviews conducted with the architect and the administrative unit manager of the bazaar complex. The second stage consists of a survey conducted with a group of 45 experts, composed of scholars and professionals in Turkey. The results of the study suggest that it is necessary to develop IDB, especially in physical and technological terms and its function should be reconsidered. In particular, it was seen that economic issues constituted one of the major obstacles via-a-vis the continuity of use of large-scale buildings. Furthermore, it was realized that the artworks across the building group increased the importance of preserving the buildings and contributed to the possibility of their new functions being envisaged in the culture-art axis.
A Randomized, Two-Treatments, Two-Periods, Crossover, Open label, Laboratory-Blind, Single Dose Bioequivalence Study between Vildagliptin/Metformin 50 mg/1000 mg Film Coated Tablets (Sensityn®) and Galvusmet® 50 mg/1000 mg Film Coated Tablets in healthy adults under fed conditions
Authors: Shiekmydeen J. , Siddiqi T. , Chakraborty K. , Khalaf S. , Albarazi M. , Eqtefan I. , Sliva J. 
Published: October 2023

Abstract

Aim
Vildagliptin/metformin 50 mg/1000 mg film coated tablets (Sensityn®) is being developed for the treatment of type 2 diabetes mellitus. An open label, crossover, bioequivalence study (phase I) was conducted to assess the bioequivalence between Sensityn® Film Coated Tablets (Test Product/Alpha Pharma Industries, a subsidiary of Cigalah Healthcare LLC, KAEC, Saudi Arabia) and Galvusmet® Film Coated Tablets (Reference product/Novartis Pharma, Switzerland), in healthy adults under fed conditions. Safety and tolerance were evaluated as secondary endpoints.

Materials and methods
A randomized study with two treatments, two periods, crossover, open-label, laboratory-blind, single dose, with a washout period of seven days under fed conditions in 36 healthy male subjects. These were administered medicinal drug product (Sensityn®) or the reference medicinal product (Galvusmet®); both as a single 50 mg/1000 mg oral dose, under fed conditions. Blood samples were collected for pharmacokinetic analysis before treatment and until 24.00h post-dosing in each study period. ANOVA analysis (test sequence, subjects’ nested within sequence, product and period effect) was performed using a 5% significance level for logarithmic and untransformed data for Cmax AUC0-t and AUC0-∞ and for untransformed data for Tmax, Kelimination (λz) and half-life.

Results
The results showed that Cmax, AUC0-t, and AUC0-∞ have passed the 90% CI acceptance limits of 80.00%–125.00% for vildagliptin and metformin. Consequently, the bioequivalence of Sensityn® and Galvusmet® film coated tablets was demonstrated under fed conditions. Treatment emergent adverse events were reported by 3 subjects and 1 subject following the administration of Sensityn® and the Galvusmet®, respectively.

Conclusion
The present findings confirmed that Sensityn®, the test medicinal product is bioequivalent to Galvusmet®, the reference medicinal product, in the rate and extent of absorption. Also, it has comparable safety profile. These findings support the continued development of vildagliptin/metformin 50 mg/1000 mg film coated tablets (Sensityn®) for use in patients with type 2 diabetes mellitus.
The influence of reinnervation on the results of peripheral nerve repair after injuries
Authors: Suszyński Krzysztof , Białoń Natalia , Marcol Wiesław , Górka Dariusz , Górka Mikołaj 
Published: October 2023

Abstract

Introduction
Research on the possibility of increasing the effects of after-injury reconstruction of peripheral nerves conducted in the Department of Physiology at ŚUM resulted in the development of a new method of reconstruction after peripheral nerve injuries. In this new method, we used 7-day predegenerated in situ sural nerve grafts. In clinical assessment, we concluded that recovery in motor, sensory and vegetative function after peripheral nerve injury treatment is better with the use of predegenerated grafts. The latent efficacy of reconstruction was measured months or years after reconstruction. In that amount of time, denervated synaptic sites in muscles can be reinnervated by nearby healthy non-injured nerves. It could increase motor, sensory, or vegetative function, irrespective of the effects of chirurgical treatment. We decided to investigate whether the circumstances may influence the latent efficiency of the new method of reconstruction.

Materials and Methods
Experiments were carried out on 32 patients in The Department of Neurosurgery Medical University of Silesia. Twenty patients were operated on with a predegenerated (P) implant, and 12 patients operated in the traditional method (T). As a result, 25% of patients’ reinnervation from healthy nearby nerves in the area supplied by reconstructed nerves was present. In group P, reinnervation appeared in 7 of 20 patients (35%) and in group T, in 1 from 12 (8.33%) cases.

Results
Results of the examinations were counted statistically in both groups.

Conclusion
Reinnervation from nearby healthy non-injured nerves positively influences the results of human peripheral nerve reconstruction.
Paradoxically Effects of Renin-Angiotensin System Suppression
Authors: Stoian Marilena 
Published: October 2023

Abstract
Is any specific organ protection by blocking the renin-angiotensin system? What is the role of the renin-angiotensin system (RAS) in progressive renal disease? The renoprotective effect of ACE-inhibitors and angiotensin II (Ang II) receptor blockers is not only mediated via their renal hemodynamic effects, but also through non-hemodynamic mechanisms?
What is the clinical evidence for the importance of local renin-angiotensin system (RAS)? These are several questions of a medical reality: that pharmacological blockade of reninangiotensin system (RAS) is paradoxically effective although circulating plasma renin activity (PRA) is low. An overview of the normal function of the system, as well as ramifications of its dysfunction (overactivity) and potentials for therapeutic blockade, is provided below.
PENGARUH CORPORATE SOCIAL RESPONSIBILITY TERHADAP TURNOVER INTENTION YANG DIMEDIASI OLEH ORGANIZATIONAL COMMITMENT PADA KARYAWAN PERUSAHAAN PERBANKAN
Authors: Depp Fajri , Andreas Wahyu Gunawan P.  
Published: October 2023

Penelitian ini bertujuan untuk menganalisis pengaruh dari Corporate Social Responsibility terhadap Turnover Intention para karyawan yang dimediasi oleh Organizational Commitment pada karyawan perusahaan perbankan. Penelitian ini penting terutama dalam rangka persaingan industri khususnya perbankan dimana Corporate Social Responsibility diharapkan dapat memberikan dampak negatif terhadap Turnover Intention serta Organizational Commitment berperan sebagai variabel yang memediasi pengaruh tersebut. Data dikumpulkan darisampel yang berjumlah Sembilan puluh responden dengan teknik pengambilan sampel purposive sampling. Uji hipotesis dalam penelitian ini mengunakan SEM (Structural Equation Modeling). Hasil penelitian menunjukan terdapat pengaruh positif Corporate Social Responsibility terhadap Organizational Commitment, pengaruh negative Organizational Commitment terhadap Turnover Intention serta pengaruh negatif Corporate Social Responsibility terhadap Turnover Intention melalui Organizational Commitment. Hasil penelitian ini mengungkapkan bahwa Organizational Commitment memiliki peran penting dimana selain dapat memberikan pengaruh negatif terhadap Turnover Intention para karyawan, Organizational Commitment juga dapat memediasi pengaruh negatf Corporate Social Responsibility terhadap Turnover Intention.
FAKTOR DETERMINAN LOYALITAS PELANGGAN STUDI PADA BANK DIGITAL SEABANK
Authors: Hilmawan Abiyyuta , Yanti Harti Budi 
Published: October 2023

Penelitian ini bertujuan untuk menguji faktor-faktor determinan yang mempengaruhi loyalitas pelanggan seabank. SeaBank merupakan salah satu bank digital di Indonesia yang dimiliki oleh PT Sea Grup anak perusahaan dari PT Shopee yang sebelumnya memiliki nama Bank Kesejahteraan Ekonomi (BKE). Perubahan resmi tersebut berdasarkan Surat Keputusan Deputi Komisioner Pengawas Perbankan Otoritas Jasa Keuangan Nomor KEP-12/PB.1/2021 tanggal 10 Februari 2021 tentang Penetapan Penggunaan Izin Usaha Atas Nama PT Bank Kesejahteraan Ekonomi Menjadi Izin Usaha Atas Nama PT Bank SeaBank Indonesia. Penelitian ini kemudahan aplikasi, produk , kepuasan pengguna aplikasi, keamanan sistem, risiko operasional, keunggulan seaBank sebagai variabel independen, loyalitas pelanggan sebagai variabel dependen. Penelitian ini merupakan penelitian kuantitatif. Sumber data yang digunakan adalah data primer. dengan mengambil sampel sebanyak 200 pelanggan seaBank berdasarkan metode purposive sampling. Hasil penelitian membuktikan bahwa kemudahan aplikasi, kepuasan pengguna aplikasi, keamanan sistem, dan keunggulan SeaBank yang ada pada SeaBank berpengaruh positif terhadap loyalitas pelanggan. Adapun produk dan risiko operasional tidak berpengaruh terhadap loyalitas pelanggan.
OPTIMALISASI KESADARAN MANAJEMEN SUMBER DAYA MANUSIA DI RUMAH SAKIT TENTANG SISTEM MANAJEMENKESELAMATAN DAN KESEHATAN KERJA (SMK3)
Authors: Andriany Nova , Tiarapuspa  
Published: October 2023

Rumah sakit merupakan lokasi kerja yang memiliki risiko yang sangat besar terhadap keselamatan dan kesehatan para pekerja. Banyak penelitian mengindikasikan bahwa permasalahan kesehatan dan kecelakaan kerja yang sering terjadi pada fasilitas dan layanan kesehatan dibandingkan tempat lain. Gunanya penting untuk mengoptimalkan kesadaran manajemen sumber daya manusia terhadap meningkatnya implementasi Manajemen Keselamatan dan Kesehatan Kerja (SMK3). Metodologi yang digunakan dalam penelitian menggunakan penelitian kepustakaan, yang didasarkan pada hasil penelitian implementasi Sistem Manajemen Keselamatan dan Kesehatan Kerja (SMK3) baik di lembaga rumah sakit yang dikelola oleh pemerintah provinsi/kabupaten/kota maupun pihak swasta. Hasil penelitian ini menunjukkan bahwa dengan meningkatkan kesadaran manajemen sumber daya manusia mengenai tata cara penerapan Sistem Manajemen Keselamatan dan Kesehatan Kerja (SMK3) dapat mengendalikan, meminimalisir, dan menghapus risiko di rumah sakit. Keberhasilan terhadap peningkatan kesadaran sumber daya manusia dalam suatu organisasi, tidak lepas dari komitmen dan sosialisasi tentang SMK3 yang dilakukan secara berkesinambungan.
CHALLENGES AND DILEMMATIC CONDITION OF HUMAN RESOURCE MANAGEMENT DURING THE FOURTH INDUSTRIAL REVOLUTION (4IR)
Authors: Tasa Gome Sri Wijaya , Tiarapuspa  
Published: October 2023

Economic growth necessitates a circular economy in which production and productivity must be improved quickly. One of the major needs of economic management is efficiency throughout the process, one of which is the employment of fewer employees who are replaced by IT and advanced machinery. The purpose of this work is to present the problems and dilemmatic state of that situation by acquiring information and data from current reviews and research articles published in scientific publications. According to this viewpoint, the large population, particularly those of productive age, may be projected as prospective primary participants in the economic sector. These can be accomplished through the development of IT skills. This issue necessitates government attention and a vital role in which human skill vision may be improved via education and training. The demographic dividend can be tailored to boost economic growth in the coming years. Furthermore, initiative, innovation, and entrepreneurship must be essential human resource skills.
PENGARUH SOCIAL MEDIA MARKETING ACTIVITIES TERHADAP CUSTOMER LOYALTY
Authors: Zelia Zeyna , Moch Sabur  
Published: October 2023

Penelitian ini bertujuan untuk menganalisis pengaruh social media marketing activities terhadap customer loyalty melalui CED (customer equity drivers) yang terdiri dari 3 variabel yaitu value equity, brand equity, dan relationship equity. Sampel pada penelitian ini menggunakan non-probability sampling, dengan teknik yang diambil yaitu purposive sampling. Pengujian ini menggunakan alat analisis Confirmatory Factor Analysis (CFA) dalam Structural Equation Model (SEM) dengan bantuan software AMOS. Hasil penelitian ini menunjukan terdapat pengaruh positif Social Media Marketing Activities terhadap Customer Loyalty melalui CED (customer equity drivers).
PENGARUH CAR, NPF, FDR DAN BOPO TERHADAP PROFITABILITAS (ROA) PADA BANK UMUM SYARIAH (STUDI KASUS: BANK SYARIAH YANG TERDAFTAR DI OJK 2018-2022)
Authors: Supardi Putri Lufianda , Syafri  
Published: October 2023

Riset ini mempunayi tujuan untuk menguji dan memahami pengaruhnya Capital Adequacy Ratio, Non Performing Financing, Financing to Deposit Ratio dan Beban Operasional Pendapatan Operation terhadap profitabilitas (Return On Asset) Bank Umum Syariah di Indonesia yang terdaftar di OJK periode 2018-2022. Riset ini menggunakan purposive sampling dengan jumlah sampel ada 6 Bank Umum Syariah dengan metode pengamatan selama 5 tahun. Data diperoleh dari laporan tahunan masing-masing Bank Umum Syariah. Analisis data menggunakan regresi data panel. Hasil penelitian memperlihatkan yakni secara parsial variabel Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR) dan Beban Operasional Pendapatan Operation (BOPO) memengaruhi negatif terhadap Return On Asset (ROA), sedangkan Non Performing Financing (NPF) tidak memengaruhi kepada Return On Asset (ROA).
Endovascular glue embolization of the medial posterior choroidal artery aneurysm: A case report and a literature review
Authors: Jha Vikas Chandra , Alam Mohammad Shahnawaz , Sinha Vivek Sharan , Verma Gaurav , Kumar Nitish , Jain Rahul 
Published: October 2023

Background:
The medial posterior choroidal artery (MPCA) aneurysm is extremely uncommon. Thus yet, just a few cases have been reported. Due to the deep position, narrow lumen, fragile walls, and extensive tortuosity, both endovascular and microsurgical procedures are strictly limited. A case study of successful endovascular glue embolization of a left MPCA aneurysm and a literature review is included in this report.

Case Description:
A 17-year-old female arrived at our institution 2 days after suffering a major intraventricular hemorrhage with a minor subarachnoid hemorrhage. Digital subtraction angiography revealed a left MPCA aneurysm. The patient underwent a successful endovascular glue embolization and had a favorable functional outcome.

Conclusion:
Endovascular glue embolization yielded favorable clinical and angiographic results in MPCA aneurysms where microcatheter access and maneuverability are challenging.
Utility of sodium fluorescein in recurrent cervical vagus schwannoma surgery
Authors: Marrone Salvatore , Sanz Julio Alberto Andres , Cacciotti Guglielmo , Campione Alberto , Boccacci Fabio , Fraschetti Flavia , Iacopino Domenico Gerardo , Mastronardi Luciano 
Published: October 2023

Background:
Cervical schwannoma is a rare neoplasm that usually occurs like a nondolent lateral neck mass but when growing and symptomatic requires radical excision. Sodium fluorescein (SF) is a dye that is uptake by schwannomas, which makes it amenable for its use in the resection of difficult or recurrent cases.

Methods:
We describe the case of a patient presenting with a recurrence of a vagus nerve schwannoma in the cervical region and the step-by-step technique for its complete microsurgical exeresis helped by the use of SF dye.

Results:
We achieved a complete microsurgical exeresis, despite the presence of exuberant perilesional fibrosis, by exploiting the ability of SF to stain the schwannoma and nearby tissues. That happens due to altered vascular permeability, allowing us to better differentiate the lesion boundaries and reactive scar tissue under microscope visualization (YELLOW 560 nm filter).

Conclusion:
Recurrent cervical schwannoma might represent a surgical challenge due to its relation to the nerve, main cervical vessels, and the scar tissue encompassing the lesion. Although SF can cross both blood–brain and blood–tumor barriers, the impregnation of neoplastic tissue is still greater than that of nonneoplastic peripheric tissues. Such behavior may facilitate a safer removal of this kind of lesion while respecting contiguous anatomical structures.
Diagnostics of Regions Resource Potential in the Context of Socio-Economic Development
Authors: Zaytsev Andrey , Dmitriev Nikolay , Kichigin Oleg 
Published: October 2023

Purpose: The purpose of the study is to study the possibilities for diagnosing the resource potential of the regions, taking into account the indicators of their socio-economic development.

Theoretical framework: To conduct the study, the indicators characterizing the socio-economic development of the regions were analyzed; Based on the selected indicators, indices of sub-potentials and integral estimates of the resource potential of the regions were calculated.

Design/methodology/approach: The diagnostics of the resource potential of the regions is carried out by means of an integral assessment of sub-potentials through an indicative analysis, where the average values for the country are the standard. The obtained indicative estimates (indices) for the sub-potentials of the resource potential make it possible to identify rent-forming conditions in the regions. It is proposed to use a “simplified” diagnostic model for the study, which contains the main indicators for analysis; in the "enlarged" model, it is planned to use an expanded range of indicators to identify dependencies, taking into account their dynamic changes. Approbation was carried out in the Russian region - Novgorod region.

Findings: As a result of the study, indicative estimates (indices) of the subpotentials of the resource potential of the analyzed regions were obtained, and their integral estimates of the resource potential were determined. The diagnostics of the resource potential made it possible to rank the regions according to the factor conditions of socio-economic development, as well as to lay the basis for assessing the effectiveness of the use of regional resource opportunities.

Research, Practical & Social implications: The study expands scientific knowledge in the field of formation and use of the resource potential of the regions. Improving the assessment system within the proposed approach for conducting diagnostics for specific regional tasks will allow for a competent regional policy with a focus on the strengths and weaknesses of the socio-economic development of the region.

Originality/value: The value of the study lies in the ranking of regions depending on resource conditions, which can help determine rent-forming factors and build an assessment of the efficiency of using resource potential.
The damages of processus vermicularis and Meckel’s diverticulum in gun–shoot abdominal woundings
Authors: Lurin I. A. , Khoroshun E. M. , Vorovsky O. O. , Nehoduiko V. V. , Makarov V. V. , Panasenko S. I. , Gumenuk K. V. , Ossovskyi O. V. , Yakymova T. P. , Saliutin R. V. 
Published: October 2023

Objective. Determination of the damages peculiarities in processus vermicularis and Meckel’s diverticulum in a gun–shot abdominal woundings and tactics of their surgical treatment.
Materials and methods. Analysis of the gun–shot abdominal woundings has been witnessed the presence of isolated and combined damages of processus vermicularis and Meckel’s diverticulum in 0.18 and 0.06% patients, accordingly. All the wounded persons were the men, their average age have constituted (32±0.3) yrs old. The shrapnel woundings have occurred in 92.4% patients, and the bullet – in 7.6%. Damages of the processus vermicularis base have dominated in its descendent localization, the damages of processus vermicularis and Meckel’s diverticulum were combined with such intestinal affections.
Results. All the damages of Meckel’s diverticulum and processus vermicularis were revealed intraoperatively. All the hospitalized patients have had the pain syndrome, the peritonitis signs and free liquid in a small pelvis. Surgical tactics consisted of resection of processus vermicularis (in 2 patients using laparoscopic approach), and in the Meckel’s diverticulum woundings the operative intervention volume have included a wedge–like resection of the small intestine part with diverticulum or segmental intestinal resection with formation of the side to side ileo–ileoanastomosis.
Conclusion. The damages of processus vermicularis and Meckel’s diverticulum constitute a rare combat woundings, which occurs in combined intestinal trauma, what constitute the need for its detailed intraoperative revision. Operative tactics in damages of processus vermicularis and Meckel’s diverticulum constitutes their resection and restoration of intestinal integrity and may be realized through laparoscopic access.
Emergence and rapid dissemination of highly resistant NDM-14-producing Klebsiella pneumoniae ST147, France, 2022
Authors: Emeraud Cécile , Mahamat Aba , Jousset Agnès B. , Bernabeu Sandrine , Goncalves Tania , Pommier Camille , Girlich Delphine , Birer Aurélien , Rodriguez Christophe , Pawlotsky Jean-Michel , Naas Thierry , Bonnin Rémy A. , Dortet Laurent 
Published: October 2023

Background
Since 2021, an emergence of New Delhi metallo-β-lactamase (NDM)-14-producing Klebsiella pneumoniae has been identified in France. This variant with increased carbapenemase activity was not previously detected in Enterobacterales.

Aim
We investigated the rapid dissemination of NDM-14 producers among patients in hospitals in France.

Methods
All NDM-14-producing non-duplicate clinical isolates identified in France until June 2022 (n = 37) were analysed by whole genome sequencing. The phylogeny of NDM-14-producers among all K. pneumoniae sequence type (ST) 147 reported in France since 2014 (n = 431) was performed. Antimicrobial susceptibility testing, conjugation experiments, clonal relationship and molecular clock analysis were performed.

Results
The 37 NDM-14 producers recovered in France until 2022 belonged to K. pneumoniae ST147. The dissemination of NDM-14-producing K. pneumoniae was linked to a single clone, likely imported from Morocco and responsible for several outbreaks in France. The gene bla
NDM-14 was harboured on a 54 kilobase non-conjugative IncFIB plasmid that shared high homology with a known bla
NDM-1-carrying plasmid. Using Bayesian analysis, we estimated that the NDM-14-producing K. pneumoniae ST147 clone appeared in 2020. The evolutionary rate of this clone was estimated to 5.61 single nucleotide polymorphisms per genome per year. The NDM-14 producers were highly resistant to all antimicrobials tested except to colistin, cefiderocol (minimum inhibitory concentration 2 mg/L) and the combination of aztreonam/avibactam.

Conclusion
Highly resistant NDM-14 producing K. pneumoniae can rapidly spread in healthcare settings. Surveillance and thorough investigations of hospital outbreaks are critical to evaluate and limit the dissemination of this clone.