bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polystyrene microplastics mediate cell cycle arrest, apoptosis, and autophagy in the G2/M phase through ROS in grass carp kidney cells
Authors: Lu Hongmin , Hou Lulu , Zhang Yue , Guo Tiantian , Wang Yu , Xing Mingwei 
Published: December 2023

AbstractMicroplastics (MPs) have attracted widespread worldwide attention as a new pollutant. However, the role of reactive oxygen species (ROS) and cell cycle in nephrotoxicity induced by different concentrations of polystyrene microplastics (PS‐MPs) is unknown. This study used grass carp kidney cells (CIK) treated with different concentrations of PS‐MPs (0, 0.012, 0.0625, and 0.5 mg L−1) as subjects. With the increase of PS‐MPs concentration, the levels of ROS and malonaldehyde increased, while the level of total antioxidant capacity, superoxide Dismutase (SOD), and glutathione (GSH) activity decreased. The expression of BUB1 mitotic checkpoint serine/threonine kinase (BUB1), cyclin‐dependent kinase (CDK1), CDK2, CyclinB1, cell division cycle 20 homolog (CDC20), and B‐cell lymphoma‐2, sequestosome 1 decreased significantly. Nevertheless, the expression of Caspase 3, Cleave‐Caspase 3, cytochrome c (Cytc), BCL2‐associated X, apoptosis regulator, poly ADP‐ribose polymerase (PARP), Cleave‐PARP, Caspase 9, autophagy immunoblot kit (LC3), and Beclin1 increased. Our research shows that PS‐MPs can trigger oxidative stress and induce cell cycle arrest, apoptosis, and autophagy in CIK cells by regulating ROS. This work provides a theoretical basis for cellular biology and toxicology mechanisms and new insights into the potential risks to animals from MPs exposure in the environment.
Blockade of phosphodiesterase 5 by sildenafil reduces tumor growth and potentiates tumor‐killing ability of cisplatin in vivo against T cell lymphoma: Implication of modulated apoptosis, reactive oxygen species homeostasis, glucose metabolism, and pH regulation
Authors: Rawat Shiv Govind , Tiwari Rajan Kumar , Kumar Ajay 
Published: December 2023

AbstractIn the past years, PDE5 has emerged as a promising therapeutic target for many cancers due to its highly upregulated expression. Interestingly, a recent in vitro study by our group has shown the antitumor and chemopotentiating action of sildenafil against T cell lymphoma. Our study showed that lower doses of sildenafil (50 μM) and cisplatin (0.5 μg/mL) exhibited 4% and 23% cytotoxicity against HuT78 cells, respectively, which was dramatically increased up to 50% when treated with both. Hence, the present study was designed to evaluate the antitumor and chemo‐potentiating action of sildenafil in a murine model of T cell lymphoma (popularly called as Dalton's lymphoma [DL]). In the present study, DL‐bearing mice were administered with vehicle (PBS), sildenafil (5 mg/kg bw), cisplatin (5 mg/kg bw), and sildenafil and cisplatin followed by evaluation of their impact on tumor growth by analyzing various parameters. The apoptosis was assessed by Wright–Giemsa, annexin‐V, and DAPI staining. Reactive oxygen species (ROS) level was examined through DCFDA staining. The expression of genes and proteins were estimated by RT‐PCR and Western blotting, respectively. The experimental findings of the study demonstrate for the first time that sildenafil inhibits tumor growth and potentiates tumor inhibitory ability of cisplatin by altering apoptosis, glycolysis, ROS homeostasis, and pH regulation in T cell lymphoma‐carrying host. In addition, our investigation also showed amelioration of tumor‐induced liver and kidney damage by sildenafil. Overall, the experimental data of our study strongly advocate the use and repurposing of SDF in designing promising chemotherapeutic regimens against malignancies of T cells.
Active antioxidant and aromatic films blended with persimmon (Diospyros kaki L.) and orange peel flour (Citrus sinensis) as sustainable packaging
Authors: Barone Andreza Salles , Matheus Julia Rabelo Vaz , Luchese Cláudia Leites , Marques Mônica Regina da Costa , de Souza Ana Maria Furtado , Ferreira Willian Hermogenes , Moreira Ricardo Felipe Alves , Fai Ana Elizabeth Cavalcante 
Published: December 2023

AbstractActive antioxidant and aromatic films based on persimmon (Diospyros kaki L.) cultivated according to agroecological precepts with orange peel flour (Citrus sinensis) and glycerol addition were developed by casting technique and characterized. The films were largely red and yellow appearance color, indicating a natural tendency to maintain the color of the persimmon pulp ripe. Scanning electron microscopy revealed a homogeneous and compact structure of the films, which obtained a rougher texture with the addition of glycerol. The addition of orange peel flour to the film‐forming solution proportionally increased the total phenolic content and antioxidant capacity of the persimmon puree films. Volatile compounds belonging to different chemical classes were identified, including limonene, β‐ionone, linolenic acid, palmitic acid, and vaccenic acid, which influence the overall aroma, as they were detected above their odor thresholds, and the functional properties of these films. Furthermore, the thermogravimetric analysis showed two important degradation steps related to glycerol and pectin (130–230°C) and decomposition of the polymer structure (above 300°C), guaranteeing the processability of the raw materials under conditions of higher temperatures than those normally used in industrial food packaging products in a circular economy context. This study indicates the potential for formation of persimmon‐based films incorporated into orange peel flour as active antioxidant films for use in drinks and tea bags as a flavoring or as intermediate layers used between slices of cheese, avoiding direct contact with food, facilitating its separation, as some application examples.Highlights
Persimmon and orange peel flour films were developed by casting.
Antioxidant and sensorial properties of blended films were evaluated.
Volatile compounds were identified, including limonene and vaccenic acid.
Circular economy principles were used to avoid postharvest fruit losses.
New duality-invariant models for nonlinear supersymmetric electrodynamics
Authors: Kuzenko Sergei M. , Stirling Jake C. 
Published: December 2023

Abstract
We propose a new family of U(1) duality-invariant models for nonlinear $$ \mathcal{N} $$
N
= 1 supersymmetric electrodynamics coupled to supergravity. It includes the Cribiori-Farakos-Tournoy-van Proeyen supergravity-matter theory for spontaneously broken local supersymmetry with a novel Fayet-Iliopoulos term without gauged R-symmetry. We present superconformal duality-invariant models, as well as new U(1) duality-invariant models for spontaneously broken local supersymmetry.
Clinical characteristics and treatment outcomes of Asian patients with T-cell large granular lymphocytic Leukemia: a single-center analysis of 67 cases
Authors: Park Taekeun , Byun Ja Min , Shin Dong-Yeop , Koh Youngil , Hong Junshik , Yoon Sung-Soo , Chang Yoon Hwan , Kim Inho 
Published: December 2023

AbstractLarge granular lymphocytic (LGL) leukemia is a clonal lymphoproliferative disorder of LGLs derived from cytotoxic T lymphocytes or natural killer cells. However, the clinical features and treatment responses are still not fully understood because of the rarity of the disease. To describe and assess a cohort of patients with T-cell large granular lymphocytic leukemia (T-LGLL). Single-center, retrospective, observational study. We retrospectively collected the clinical data of patients diagnosed with T-LGLL at Seoul National University Hospital since 2006. We included 67 patients in this study. The median age at diagnosis was 60 years. Additionally, 37 patients (55%) were symptomatic, and 25 (37%) had splenomegaly; 54 patients (81%) required treatment. Cyclophosphamide (n = 35), methotrexate (n = 25), and cyclosporin A (n = 19) were used most frequently for treatment, and their overall response rates were similar: cyclophosphamide (77%), methotrexate (64%), and cyclosporin A (63%). Splenomegaly was associated with an increased response rate to first-line therapy and a decreased complete response rate. Thrombocytopenia was associated with decreased response rates to cyclophosphamide, methotrexate, cyclosporin A, and steroids. In contrast, a high LGL number (> 2000/µL) in the peripheral blood smear was associated with increased response rates to cyclophosphamide, methotrexate, cyclosporin A, and steroids. This study describes the clinical features and treatment outcomes of patients with T-LGLL, providing valuable information for clinical decision-making regarding T-LGLL treatment.
Global–local multidisciplinary optimisation for the evaluation of local constraints on finer meshes in preliminary aircraft design
Authors: Sferza Massimo , Ninic Jelena , Glock Florian , Hofer Christoph , Daoud Fernass , Chronopoulos Dimitrios , van der Zee Kristoffer 
Published: December 2023

AbstractMultidisciplinary design optimisation (MDO) is a methodology increasingly being used in the preliminary design of aircraft. To limit the computational cost of the procedure, it is generally based on coarse models, which do not accurately capture the internal deformation of details with a complex geometry. Therefore, it is not possible to apply constraints in these areas and designers are limited to a conservative pre-sizing of these parts, which are then kept fixed during the optimisation. In this paper we expose the limitations of this approach and present a novel methodology for the preliminary sizing of aircraft, based on global–local MDO. The commonly used coarse model is used together with finer local models, for the parts where additional accuracy is needed. The global–local analysis solves the internal deformation field with sufficient accuracy for the evaluation of local constraints. Furthermore, thanks to the formulation we introduce to compute the coupled sensitivities, the optimiser successfully finds a locally feasible design.
Peatland restoration pathways to mitigate greenhouse gas emissions and retain peat carbon
Authors: Mander Ülo , Espenberg Mikk , Melling Lulie , Kull Ain 
Published: December 2023

AbstractPeatlands play a crucial role in the global carbon (C) cycle, making their restoration a key strategy for mitigating greenhouse gas (GHG) emissions and retaining C. This study analyses the most common restoration pathways employed in boreal and temperate peatlands, potentially applicable in tropical peat swamp forests. Our analysis focuses on the GHG emissions and C retention potential of the restoration measures. To assess the C stock change in restored (rewetted) peatlands and afforested peatlands with continuous drainage, we adopt a conceptual approach that considers short-term C capture (GHG exchange between the atmosphere and the peatland ecosystem) and long-term C sequestration in peat. The primary criterion of our conceptual model is the capacity of restoration measures to capture C and reduce GHG emissions. Our findings indicate that carbon dioxide (CO2) is the most influential part of long-term climate impact of restored peatlands, whereas moderate methane (CH4) emissions and low N2O fluxes are relatively unimportant. However, lateral losses of dissolved and particulate C in water can account up to a half of the total C stock change. Among the restored peatland types, Sphagnum paludiculture showed the highest CO2 capture, followed by shallow lakes and reed/grass paludiculture. Shallow lakeshore vegetation in restored peatlands can reduce CO2 emissions and sequester C but still emit CH4, particularly during the first 20 years after restoration. Our conceptual modelling approach reveals that over a 300-year period, under stable climate conditions, drained bog forests can lose up to 50% of initial C content. In managed (regularly harvested) and continuously drained peatland forests, C accumulation in biomass and litter input does not compensate C losses from peat. In contrast, rewetted unmanaged peatland forests are turning into a persistent C sink. The modelling results emphasized the importance of long-term C balance analysis which considers soil C accumulation, moving beyond the short-term C cycling between vegetation and the atmosphere.
Structure-aware decoupled imputation network for multivariate time series
Authors: Ahmed Nourhan , Schmidt-Thieme Lars 
Published: December 2023

AbstractHandling incomplete multivariate time series is an important and fundamental concern for a variety of domains. Existing time-series imputation approaches rely on basic assumptions regarding relationship information between sensors, posing significant challenges since inter-sensor interactions in the real world are often complex and unknown beforehand. Specifically, there is a lack of in-depth investigation into (1) the coexistence of relationships between sensors and (2) the incorporation of reciprocal impact between sensor properties and inter-sensor relationships for the time-series imputation problem. To fill this gap, we present the Structure-aware Decoupled imputation network (SaD), which is designed to model sensor characteristics and relationships between sensors in distinct latent spaces. Our approach is equipped with a two-step knowledge integration scheme that incorporates the influence between the sensor attribute information as well as sensor relationship information. The experimental results indicate that when compared to state-of-the-art models for time-series imputation tasks, our proposed method can reduce error by around 15%.
Desiring to Know: Curiosity as a Tendency toward Discovery
Authors: Summa Michela 
Published: December 2023

AbstractBoth the commonsensical and the philosophical understanding of curiosity as the desire to know display similar ambiguities. In philosophy, such ambiguities have further repercussions, inasmuch as inquiries into curiosity, in addition to being a field of philosophical research in itself, also have meta-theoretical implications concerning the idea of philosophy one embraces. This holds true for Edmund Husserl’s discussion of curiosity: his phenomenological analysis of curiosity as an object of inquiry is crucially connected with a specific meta-theoretical understanding of philosophy as an exploratory endeavor. This article analyses the relevance of the phenomenological analyses of curiosity against the background of the discussion of a polarization in the appreciation of the role of curiosity for philosophy and of the tasks Husserl assigns to philosophy. It focuses on how Husserl’s appraisal of curiosity in philosophy is tied to his concrete analyses of the intentional structure of ordinary curiosity. Crucial for this appraisal and for its meta-theoretical implications is the analysis of the relation between curiosity and the basic structure of intentionality as tendency.
Vaccine Effectiveness Against SARS-CoV-2 Related Hospitalizations in People who had Experienced Homelessness or Incarceration – Findings from the Minnesota EHR Consortium
Authors: DeSilva Malini B. , Knowlton Gregory , Rai Nayanjot K. , Bodurtha Peter , Essien Inih , Riddles John , Mehari Lemlem , Muscoplat Miriam , Lynfield Ruth , Rowley Elizabeth AK , Chamberlain Alanna M. , Patel Palak , Hughes Alexandria , Dickerson Monica , Thompson Mark G. , Griggs Eric P. , Tenforde Mark , Winkelman Tyler NA , Benitez Gabriela Vazquez , Drawz Paul E. 
Published: December 2023

AbstractCOVID-19 disproportionately affects people experiencing homelessness or incarceration. While homelessness or incarceration alone may not impact vaccine effectiveness, medical comorbidities along with social conditions associated with homelessness or incarceration may impact estimated vaccine effectiveness. COVID-19 vaccines reduce rates of hospitalization and death; vaccine effectiveness (VE) against severe outcomes in people experiencing homelessness or incarceration is unknown. We conducted a retrospective, observational cohort study evaluating COVID-19 vaccine VE against SARS-CoV-2 related hospitalization (positive SARS-CoV-2 molecular test same week or within 3 weeks prior to hospital admission) among patients who had experienced homelessness or incarceration. We utilized data from 8 health systems in the Minnesota Electronic Health Record Consortium linked to data from Minnesota’s immunization information system, Homeless Management Information System, and Department of Corrections. We included patients 18 years and older with a history of experiencing homelessness or incarceration. VE and 95% Confidence Intervals (CI) against SARS-CoV-2 hospitalization were estimated for primary series and one booster dose from Cox proportional hazard models as 100*(1-Hazard Ratio) during August 26, 2021, through October 8, 2022 adjusting for patient age, sex, comorbid medical conditions, and race/ethnicity. We included 80,051 individuals who had experienced homelessness or incarceration. Adjusted VE was 52% (95% CI, 41–60%) among those 22 weeks or more since their primary series, 66% (95% CI, 53–75%) among those less than 22 weeks since their primary series, and 69% (95% CI: 60–76%) among those with one booster. VE estimates were consistently lower during the Omicron predominance period compared with the combined Omicron and Delta periods. Despite higher exposure risk, COVID-19 vaccines provided good effectiveness against SARS-CoV-2 related hospitalizations in persons who have experienced homelessness or incarceration.
The Association Between Adverse Childhood Experiences (ACEs), Bullying Victimization, and Internalizing and Externalizing Problems Among Early Adolescents: Examining Cumulative and Interactive Associations
Authors: Trompeter Nora , Testa Alexander , Raney Julia H. , Jackson Dylan B. , Al-shoaibi Abubakr A. A. , Ganson Kyle T. , Shao Iris Yuefan , Nagata Jason M. 
Published: December 2023

AbstractBoth adverse childhood experiences (ACEs) and bullying victimization are linked with mental health problems in adolescents. However, little is known about the overlap between the two factors and how this impacts adolescent mental health problems (i.e., internalizing and externalizing problems). The current study analyzed data from 8,085 participants (47.7% female; 44.1% racial/ethnic minority) in the Adolescent Brain Cognitive Development (ABCD) study, baseline (2016–2018, ages 9–10 years) to Year 2. Regression analyses were used to estimate associations between ACEs, bullying victimization and mental health problems, respectively, adjusting for sex, race/ethnicity, country of birth, household income, parental education, and study site. The findings showed that both ACEs and bullying victimization were independently associated with higher internalizing and higher externalizing problems. However, no significant interaction was found between ACEs and bullying victimization. Overall, the results align with the cumulative risk model of adversity, linking cumulative ACEs and bullying victimization to internalizing and externalizing problems in early adolescents.
Prevalence of portal vein thrombosis in non-alcoholic fatty liver disease: a meta-analysis of observational studies
Authors: Stupia Roberta , Lombardi Rosa , Cattazzo Filippo , Zoncapè Mirko , Mantovani Anna , De Marco Leonardo , Mantovani Alessandro , Fracanzani Anna Ludovica , Sacerdoti David , Dalbeni Andrea 
Published: December 2023

AbstractPortal vein thrombosis (PVT) is a common complication of cirrhosis as a result of portal hypertension and modification in the hemostatic balance. Accumulating evidence now suggests that patients with non-alcoholic fatty liver disease (NAFLD), especially those with advanced forms, have an increased risk of PVT. Hence, we performed a meta-analysis of observational studies to estimate the overall prevalence of PVT in patients with NAFLD and its advanced forms compared with patients with advanced liver diseases from other etiologies. We systematically searched PubMed, Scopus and Web of Science databases from the inception date to December 30th 2022, using predefined keywords, to identify observational studies. Meta-analysis was performed using random-effects modeling. We included five observational studies for a total of 225,571 patients. Of these, 26,840 (11.9%) patients had NAFLD, whereas the PVT prevalence was 8.5% (n = 2,280). When compared with patients with advanced liver diseases from other etiologies, patients with NAFLD and its advanced forms had a higher risk of prevalent PVT (OR 1.34, 100% CI 1.07–1.67 p < 0,01). The between-study heterogeneity was substantial (I2 = 88%). This meta-analysis suggests that compared with patients with advanced liver diseases from other etiologies, patient with NAFLD and its advanced forms had a higher risk of prevalent PVT. Further research is required to understand the complex link between NAFLD/NASH and PVT development.
Non-targeted LC–MS/MS metabolomic profiling of human plasma uncovers a novel Mediterranean diet biomarker panel
Authors: Macias Shirin , Yilmaz Ali , Kirma Joseph , Moore Sarah E. , Woodside Jayne V. , Graham Stewart F. , Green Brian D. 
Published: December 2023

Abstract
Introduction
Consumption of a Mediterranean diet (MD) has established health benefits, and the identification of novel biomarkers could enable objective monitoring of dietary pattern adherence.

Objectives
The present investigation performed untargeted metabolomics on blood plasma from a controlled study of MD adherence, to identify novel blood-based metabolite biomarkers associated with the MD pattern, and to build a logistic regression model that could be used to characterise MD adherence.

Methods
A hundred and thirty-five plasma samples from n = 58 patients collected at different time points were available. Using a 14-point scale MD Score (MDS) subjects were divided into ‘high’ or ‘low’ MDS adherence groups and liquid chromatography-mass spectrometry (LC–MS/MS) was applied for analysis.

Results
The strongest association with MDS was pectenotoxin 2 seco acid (r = 0.53; ROC = 0.78), a non-toxic marine xenobiotic metabolite. Several lipids were useful biomarkers including eicosapentaenoic acid, the structurally related lysophospholipid (20:5(5Z,8Z,11Z,14Z,17Z)/0:0), a phosphatidylcholine (P-18:1(9Z)/16:0) and also xi-8-hydroxyhexadecanedioic acid. Two metabolites negatively correlated with MDS, these were the monoacylglycerides (0:0/16:1(9Z)/0:0) and (0:0/20:3(5Z,8Z,11Z)/0:0). By stepwise elimination we selected a panel of 3 highly discriminatory metabolites and developed a linear regression model which identified ‘high MDS’ individuals with high sensitivity and specificity [AUC (95% CI) 0.83 (0.76–0.97)].

Conclusion
Our study highlights the utility of metabolomics as an approach for developing novel panels of dietary biomarkers. Quantitative profiling of these metabolites is required to validate their utility for evaluating dietary adherence.