bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative [68Ga]Ga-PSMA-11 PET biomarkers for the analysis of lesion-level progression in biochemically recurrent prostate cancer: a multicentre study
Authors: Kendrick Jake , Francis Roslyn J. , Hassan Ghulam Mubashar , Rowshanfarzad Pejman , Ong Jeremy S. L. , Barry Nathaniel , Rusanov Branimir , Ebert Martin A. 
Published: October 2023

Abstract[68Ga]Ga-PSMA-11 PET has become the standard imaging modality for biochemically recurrent (BCR) prostate cancer (PCa). However, its prognostic value in assessing response at this stage remains uncertain. The study aimed to assess the prognostic significance of radiographic patient-level patterns of progression derived from lesion-level biomarker quantitation in metastatic disease sites. A total of 138 BCR PCa patients with both baseline and follow-up [68Ga]Ga-PSMA-11 PET scans were included in this analysis. Tumour response was quantified at the lesion level using commonly used quantitative parameters (SUVmean, SUVmax, SUVpeak, volume), and patients were classified as systemic, mixed, or no-progression based on these response classifications. A total of 328 matched lesions between baseline and follow-up scans were analysed. The results showed that systemic progressors had a significantly higher risk of death than patients with no progression with SUVmean demonstrating the highest prognostic value (HR = 5.70, 95% CI = 2.63–12.37, p < 0.001, C-Index = 0.69). Moreover, progressive disease as measured by SUVmean using the radiographic PSMA PET Progression Criteria (rPPP) was found to be significantly prognostic for patient overall survival (HR = 3.67, 95% CI = 1.82–7.39, p < 0.001, C-Index = 0.65). This work provides important evidence supporting the prognostic utility of PSMA response quantitation in the BCR setting.
Villous trophoblast growth in pregnancy at high altitude
Authors: Mayhew T. M. , Bowles C. , Yücel F. 
Published: October 2023

The trophoblastic epithelium of placental villi exhibits continuous turnover. Phases of proliferation, recruitment, maturation, terminal differentiation (apoptosis) and extrusion exist in steady state and occur in distinctive spatial compartments, viz. cytotrophoblast cells (CT), syncytiotrophoblast (ST), syncytial knots (SK), denudation sites (DEN) and syncytial fragments. Hypoxia in vitro stimulates CT proliferation but inhibits recruitment into ST. Pregnancy at high altitude (HA) is associated with reduced birthweight and provides a convenient model of preplacental (hypobaric) hypoxia. HA placentas show impoverished villous growth and changes in the incidences of CT cells and SK regions. Here we examine placentas from Amerindian and nonindigenous women who completed full‐term pregnancies at low altitude (LA; 400 m; n = 25) and high altitude (HA; 3600 m; n = 45) in Bolivia. We test the hypothesis that HA pregnancy disturbs the epithelial steady state as reflected in the relative volumes and surfaces of trophoblast compartments. Masson trichrome stained tissue sections and microscopical fields were generated by uniform random sampling. Point and intersection counts were used to estimate the volumes and surface areas of nonsyncytial knots (nonSK), SK regions, syncytial bridges (SB) and denudation sites (DEN). Absolute values were compared by 2‐way analyses of variance to resolve altitudinal from ethnic effects. At LA, trophoblast comprised about 85% nonSK, 8% SK, 5% SB and 3% CT by volume. Its maternal surface area comprised about 91% nonSK, 5% SK, 2% SB, and 3% DEN. Apart from CT (the fractional volume of which increased to 4%, P < 0.05), relative volumes of trophoblast compartments did not alter significantly at HA. However, there was a roughly 30% reduction in absolute volume of trophoblast at HA (P < 0.001) which could be explained mainly by a decrease in volume of nonSK regions (P < 0.001). The volume of CT was unaltered. Absolute surface areas of villi also declined at HA (by 20%, P < 0.01) and, again, this was attributed mainly to nonSK. The findings confirm that poor villous growth is partly due to failure of trophoblast to attain the growth seen at LA. The reduced trophoblastic growth occurs despite an increase in relative volume of CT cells (consistent with previously reported increases in proliferative activity) and, probably, by a combination of compromised syncytial fusion and continuing extrusion of syncytial fragments.
Planetary system architectures with low-mass inner planets
Authors: Desgrange C. , Milli J. , Chauvin G. , Henning Th. , Luashvili A. , Read M. , Wyatt M. , Kennedy G. , Burn R. , Schlecker M. , Kiefer F. , D’Orazi V. , Messina S. , Rubini P. , Lagrange A.-M. , Babusiaux C. , Matrà L. , Bitsch B. , Bonavita M. , Delorme P. , Matthews E. , Palma-Bifani P. , Vigan A. 
Published: October 2023

Context.The discovery of planets orbiting at less than 1 au from their host star and less massive than Saturn in various exoplanetary systems revolutionized our theories of planetary formation. The fundamental question is whether these close-in low-mass planets could have formed in the inner disk interior to 1 au, or whether they formed further out in the planet-forming disk and migrated inward. Exploring the role of additional giant planet(s) in these systems may help us to pinpoint their global formation and evolution.Aims.We searched for additional substellar companions by using direct imaging in systems known to host close-in small planets. The use of direct imaging complemented by radial velocity and astrometric detection limits enabled us to explore the giant planet and brown dwarf demographics around these hosts to investigate the potential connection between both populations.Methods.We carried out a direct imaging survey with SPHERE at VLT to look for outer giant planets and brown dwarf companions in 27 systems hosting close-in low-mass planets discovered by radial velocity. Our sample is composed of very nearby (<20 pc) planetary systems, orbiting G-, K-, and M-type mature (0.5–10 Gyr) stellar hosts. We performed homogeneous direct imaging data reduction and analysis to search for and characterize point sources, and derived robust statistical detection limits. The final direct imaging detection performances were globally considered together with radial velocity and astrometric sensitivity.Results.Of 337 point-source detections, we do not find any new bound companions. We recovered the emblematic very cool T-type brown dwarf GJ 229 B. Our typical sensitivities in direct imaging range from 5 to 30MJupbeyond 2 au. The non-detection of massive companions is consistent with predictions based on models of planet formation by core accretion. Our pilot study opens the way to a multi-technique approach for the exploration of very nearby exoplanetary systems with future ground-based and space observatories.
Herkunft und Verfügbarkeit pflanzlicher Rohstoffe für
die Herstellung pharmazeutischer Produkte*
Authors: Lorenz Matthias 
Published: October 2023

ZusammenfassungAn Arznei- und Aromapflanzen (MAPs) und deren Gewinnung werden höchste
Anforderungen gestellt, sowohl hinsichtlich ihrer Qualität, Sicherheit
und Wirksamkeit für den Verbraucher als auch der Nachhaltigkeit in den
Gebieten der Wildsammlung oder des Feldanbaus. Um eine gleichbleibende
Qualität der Rohware für die Herstellung von Arzneimitteln
entsprechend den Anforderungen der Arzneibücher zu
gewährleisten, müssen zahlreiche Faktoren berücksichtigt
werden.
Das schmerzende Gelenk in der Notfallambulanz
Authors: Grabe Fabian 
Published: October 2023

ZUSAMMENFASSUNGDie Vorstellung von Kindern aufgrund von unklaren Gelenkschmerzen und/oder Gelenkschwellungen ist häufig und die Unsicherheit im Umgang aufgrund der Diversität der Differenzialdiagnosen oft hoch. Die initial wegweisenden diagnostischen Maßnahmen, Differenzialdiagnosen und ersten Therapieoptionen sollten von den Erstversorgenden in der Kindernotaufnahme ausreichend sicher beherrscht und daher im Rahmen dieses Artikels erarbeitet werden.
Bildgebung bei der juvenilen idiopathischen Arthritis (JIA) – was, wann und warum?
Authors: Windschall Daniel 
Published: October 2023

ZUSAMMENFASSUNGDer Artikel gibt einen Überblick zum aktuellen Stand der Bildgebung in der Kinderrheumatologie und geht insbesondere auf den praktischen Einsatz und die technischen Aspekte der Gelenksonografie, der Magnetresonanztomografie und Röntgenbildgebung ein. Dabei werden auch die wissenschaftlichen Entwicklungen der letzten Jahre zusammengefasst und berücksichtigt. Im Treat-to-target-Konzept der Behandlung einer juvenilen idiopathischen Arthritis entwickelt sich die Bildgebung zu einem entscheidenden Aktivitätsparameter. Die Bedeutung als Remissionskriterium wird momentan in Studien untersucht.
Woran denken bei Gelenkschmerzen?
Authors: Haas Johannes-Peter 
Published: October 2023

ZUSAMMENFASSUNGGelenksbeschwerden und Schmerzen im Bereich des muskulo-skelettalen Systems gehören zu den häufigsten Symptomen in kinder- und jugendmedizinischen Praxen und Ambulanzen. Meistens handelt es sich um temporäre durch Bagatelltraumen und/oder Überlastung verursachte Beschwerden oder eine Begleitreaktion z. B. im Rahmen von Infektionserkrankungen. Wiederholte und/oder länger anhaltende Beschwerden insbesondere in gleicher Lokalisation bedürfen jedoch einer eingehenden Abklärung. Differenzialdiagnostisch ist bei unklaren Gelenksbeschwerden eine Vielzahl von Erkrankungen möglich, die zum Teil sehr selten auftreten. Dies erschwert die zielorientierte Abklärung für den Praktiker. Eine rechtzeitige Diagnostik kann einerseits das Auftreten bleibender Schäden und andererseits bedrohliche Verkäufe, die bei einigen Erkrankungen die das muskulo-skelettale System betreffen möglich sind, vermeiden helfen. Die folgende Zusammenstellung soll hier einen praxisorientierten Leitfaden bieten.
Physikalische Therapie bei juveniler idiopathischer Arthritis (JIA)
Authors: Rieblinger Manuel , Schwarz Simone , Georgi Mathias 
Published: October 2023

ZUSAMMENFASSUNGWird die Diagnose Juvenile idiopathische Arthritis gestellt, sollte dies mit einer Verordnung für Physikalische Therapie einhergehen. Dabei wird häufig die Frage gestellt:Was sind die Ziele der physikalischen Therapie und welche Maßnahmen/Therapieformen finden statt?Die Physiotherapie und die Ergotherapie sind ein wesentlicher Bestandteil einer erfolgreichen interdisziplinären Behandlung von Kindern und Jugendlichen mit JIA.Das Ziel einer jeden Behandlung ist, die Gelenkbeweglichkeit zu verbessern, zu erhalten bzw. vollständig wiederherzustellen. Die Auswahl der Maßnahmen ist dabei abhängig vom Entzündungsstadium, dem betroffenen Gelenk und vom Alter des Kindes. Die jungen Patienten möchten beispielsweise wieder schmerzfrei gehen oder greifen können, den Alltag in Kita, Schule oder in der Freizeit wieder mit Freunden oder Geschwistern meistern können. Wichtig ist auch, das Kind im späteren Verlauf an sportliche Aktivitäten heranzuführen, es für geeignete Sportarten zu begeistern.
Update zu AID-Systemen
Authors: Thomas Andreas 
Published: October 2023

ZUSAMMENFASSUNGAID-Systeme sind dabei, zum Standard der Therapie des Typ-1-Diabetes zu werden. Die klinischen Ergebnisse sind für die gesamte Patientenpopulation besser als mit jeder anderen therapeutischen Option. Zunehmend verringert sich dabei gleichzeitig das notwendige Therapiemanagement für die Patienten. Der im Vergleich zu jeder anderen Form der Insulintherapie höhere Preis wird deutlich kompensiert, weil zukünftig sowohl kostentreibende akute Komplikationen, als auch diabetische Folgeerkrankungen kaum noch auftreten werden. Vor allem aber ist auch die Verringerung der diabetesbedingten Belastungen, die Verbesserung der Therapiezufriedenheit und der Lebensqualität für die Patienten entscheidend.
Yoga bei Rückenschmerzen: Stand der Forschung
Authors: Cramer Holger , Richter Malte , Anheyer Dennis 
Published: October 2023

SummaryYoga erfreut sich rund um den Globus wachsender Beliebtheit. Viele Menschen praktizieren Yoga, um Rücken- oder Nackenschmerzen zu verringern. Studien bestätigen diese positive Wirkung von Yoga. Welche Yogastile besonders zur Schmerzreduktion geeignet sind, wurde bisher nicht erforscht. Bisher gilt der Rat, Yoga grundsätzlich in den Alltag zu integrieren und nach initialer Supervision als selbstständige Praxis weiterzuführen.
Experience with the Ankura Thoracic Stent Graft and In-situ Fenestration for the Left Subclavian Artery with the Fu-Through Needle - a Technical Overview and Comparison to
Similar Endovascular Techniques
Authors: Usai Marco Virgilio , Austermann Martin 
Published: October 2023

AbstractThoracic endovascular aortic repair (TEVAR) is a widespread minimally invasive procedure prevalently used to treat thoracic aortic pathologies. However, when the left subclavian artery
(LSA) is involved in the pathology, a more complex surgical approach is required to guarantee the perfusion of the vertebral and brachial arteries. In fact, coverage of the LSA has been
proven to be associated with a higher risk of stroke, spinal cord ischemia, and arm ischemia.Historically, carotid-subclavian bypass or subclavian transposition has been the only treatment options to restore the perfusion of the LSA. For the past 10 years, different endovascular
techniques have been implemented in the endovascular armamentarium to reduce the risk of complications related to surgical treatment such as infection, bleeding, and chylothorax.Currently, physician-modified grafts, in situ fenestration, chimneys, and branched or fenestrated devices are available. The aim of this overview is to describe the technique with
the Ankura thoracic stent graft and in situ fenestration with the Futhrough needle and thus to shed light on the different approaches by comparing their pros and cons.
Hypophosphatasie im Kindesalter
Authors: Hofmann Christine , Benoit Clemens , Girschick Hermann 
Published: October 2023

ZUSAMMENFASSUNGDie Hypophosphatasie (HPP) ist eine seltene genetische Erkrankung, welche infolge einer verminderten Alkalischen Phosphatase-Aktivität zu Problemen an Knochen, Muskeln, Zähnen, aber auch zahlreichen weiteren Organsystemen führen kann. Letztlich handelt es sich um eine metabolische Multisystemerkrankung mit sehr variablem klinischem Phänotyp bzw. Schweregrad, die alle Altersgruppen betreffen kann und zu einer signifikanten Mortalität und Morbidität bei den betroffenen Familien führt. Die klinische Verdachtsdiagnose kann durch laborchemische Untersuchungen (insbesondere die Bestimmung der AP-Aktivität), bildgebende Maßnahmen und eine humangenetische Testung erhärtet werden. Eine Anbindung betroffener Familien an ein erfahrenes Zentrum mit multidisziplinärer Betreuung erscheint sinnvoll. Die Enzymersatztherapie mit Asfotase alfa stellt eine zugelassene effektive und gut verträgliche Therapie zur Behandlung des „Knochenphänotyps“ dar. Langzeitdaten zu Wirksamkeit und Verträglichkeit sollen im Rahmen eines internationalen Registers erfasst werden.
Micro-Hardness and Surface Roughness of Bulk-Fill Composite Resin: Effect of Surface Sealant Application and Two Bleaching Regimens
Authors: Attia Reham Mohamad , Sobhy Eman Mohamed , Essa Mona El Said Abd El Hameed 
Published: October 2023

Abstract
Objectives The aim of this study was to assess the impact of applying a surface sealant and two bleaching regimens, on the micro-hardness, and surface roughness of bulk-fill composite resin
Materials and Methods One-hundred twenty specimens were prepared with a diameter of 5 mm and thickness of 4 mm using bulk-fill composite. Specimens were subdivided into group 1: (n= 60), in which Fortify surface sealant was used, and group 2 (control): (n= 60), in which specimens were only finished and polished. After applying in-office and at-home bleaching, micro-hardness and surface roughness were measured before and after bleaching. Statistical analysis was performed using Student's t-test and paired test.
Results Hardness values of group 1 were lower than values of group 2 before and after bleaching, with different bleaching procedures. Applying surface sealant and different bleaching regimens led to a significant difference of surface roughness (p < 0.001).
Conclusion Applying surface sealant decreases both micro-hardness and surface roughness. The bleaching procedures significantly affect the surface roughness, but not the micro-hardness.
Clinical Significance Surface sealant can enhance the surface roughness of bulk-fill composite in nonstress bearing area as it reduces the surface micro-hardness.
Femoral Fixation Strength as a Function of Bone Plug Length in Anterior Cruciate Ligament Reconstruction Utilizing Interference Screws
Authors: Light Jonathan J. , Firoved Amanda B. , Rocchi Vanna J. , Wellman Laurie L. , Bonner Kevin F. 
Published: October 2023

Abstract
Purpose To determine femoral construct fixation strength as bone plug length decreases in anterior cruciate ligament reconstruction (ACLR).
Methods Sixty fresh-frozen bone–patellar tendon–bone allografts were utilized and divided into 20-, 15-, and 10-mm length bone plug groups, subdivided further so that half utilized the patella side (P) for testing and half used the tibial side (T). Ten mm diameter recipient tunnels were created within the anatomic anterior cruciate ligament footprint of 60 cadaveric femurs. All bone plugs were 10 mm in diameter; grafts were fixed using a 7 × 23 mm metal interference screw. An Instron was used to determine the load to failure of each group. A one-way multivariate analysis of variance (MANOVA) was conducted to test the hypothesis that there would be one or more mean differences in fixation stability between 20- or 15-mm plug lengths (P or T) versus 10 mm T plug lengths when cross-compared, with no association between other P or T subgroups.
Results The mean load to failure of the 20 mm plugs (20 P + T) was 457 ± 66N, 15 mm plugs (15 P + T) was 437 ± 74N, and 10 mm plugs (10 P + T) was 407 ± 107N. There was no significant difference between P + T groups: 20-versus 15-mm (p = 1.000), 15-versus 10-mm (p = 0.798), and 20-versus 10-mm (p = 0.200); P + T MANOVA (p = 0.291). Within groups, there was no significant difference between patella and tibial bone plug subgroups with a pullout force range between 469 ± 56N and 374 ± 116N and p-value ranging from p = 1.000 for longer bone plugs to p = 0.194 for shorter bone plugs; P versus T MANOVA (p = 0.113).
Conclusion In this human time zero cadaver model, there was no significant difference in construct failure between 20-,15-, and 10-mm bone plugs when fixed with an interference screw within the femoral tunnel, although fixation strength did trend down when from 20- to 15- to 10-mm bone plugs.
Clinical Relevance There is a balance between optimal bone plug length on the femoral side for achieving adequate fixation as well as minimizing donor site morbidity and facilitating graft passage in ACLR. This study reveals utilizing shorter plugs with interference screw fixation is potentially acceptable on the femoral side if shorter plugs are harvested.
Remote Site Hemorrhage following Evacuation of Left Fronto-Temporo-Parietal Subdural Hematoma: A Rare Case Report and Comprehensive Literature Review
Authors: Hazra Darpanarayan , Chandy Gina Maryann , Ghosh Amit 
Published: October 2023

AbstractThis report presents a compelling case of remote site hemorrhage (RSH), a rare but severe complication associated with neurosurgery. RSH involves cerebral bleeding away from the surgical site and was first documented in 1937 by Van Gehuchten. Despite its rarity, RSH remains challenging, affecting less than 1% of cases, with an unclear cause. The case involves a 67-year-old male who developed severe symptoms within 24 hours post-surgery. The initial computed tomography scan showed an acute subdural hematoma. Surgical evacuation was followed by rapid deterioration, leading to multiple RSH and brain stem infarctions. Unfortunately, the patient did not survive. RSH poses significant morbidity and mortality risks. Potential factors include volume loss, dural opening, and blood pressure fluctuations. Management ranges from conservative approaches to surgery, with poor prognosis post-RSH intervention. This case highlights the need for thorough preoperative assessment and careful intraoperative management. It emphasizes the complexities of neurosurgery and underscores the importance of ongoing research for managing rare complications like RSH, ultimately improving patient outcomes.
Influence of tetragonal/cubic phase composition on the total ionic conductivity of Li3xLa2/3−xTiO3
Authors: Wu Qi Yun , Zheng De Yi , Mao Run Yu , Liu Chang , Wang Xu , Han Wen Bi 
Published: October 2023

Lithium lanthanum titanate (Li3xLa2/3−xTiO3, abbreviated as LLTO, where x = 0.08, 0.1, 0.12, 0.14, 0.16, and 0.167) is prepared using a conventional solid-phase method, and its crystal structure, phase composition, microstructure, and electrical properties are investigated. Experimental results indicate that when the Li content is low (x = 0.8), there exist tetragonal, cubic, and orthogonal phases in LLTO. As the Li content increases (x ≥ 0.1), the orthogonal phase disappears, and there are changes in the phase composition of tetragonal and cubic phases. When the occupancy rates of Li and La are low, the number of A-site vacancies increases, as does the electrical conductivity of LLTO. At room temperature, the ionic conductivity of LLTO increases and then decreases. The Li0.30La0.56TiO3 ceramic electrolyte exhibits the highest total ionic conductivity of 7.22 × 10−5 S/cm, a minimum activation energy of 0.31 eV, and an electrical conductivity of 6.26 × 10−11 S/cm. This paper provides a theoretical basis for subsequent research on solid Li3xLa2/3−xTiO3 electrolytes.
Modulating intrinsic anomalous Hall effect in Fe3GeTe2 monolayer via strain engineering
Authors: Guo Min , Zhou Ju , Lu Hai-Shuang , Ju Sheng , Cai Tian-Yi 
Published: October 2023

The Fe3GeTe2 monolayer, a ferromagnetic topological candidate with a high Curie temperature of 130 K, has recently garnered considerable interest. We investigated the impact of strain on the electronic, magnetic, and topological properties of the Fe3GeTe2 monolayer using density functional theory calculations. Our results showed that the Fe3GeTe2 monolayer was an itinerant ferromagnet with a high spin polarization of 69.93% and out-of-plane easy magnetization. Tensile strain had no profound impact on the anomalous Hall conductivity (AHC). However, when applying a compressive biaxial strain of −3%, the AHC at the Fermi level was dramatically enhanced to 1.62 e2/h, which is much larger than that of the bulk (0.7 e2/h) and bilayer (1.5 e2/h) material. The large AHC nearly coincided with the singularity of the energy bands near the M point. Our results highlight the potential of using strain engineering to control and optimize the properties of two-dimensional topological materials.