bluuebunny/crossref_metadata_2025_split huggingface dataset:
A commentary on Ehrlich et al. (2023): a resilience paradox for child development
Authors: Ungar Michael 
Published: November 2023

Paradoxically, resilience carries with it the risk of disorder. When understood systemically, this should come as no surprise. All complex systems demonstrate this same propensity for both positive and negative feedback loops. A thriving ecosystem eventually succumbs to its own dominance over its environment, using up available resources until its survival is threatened and its population declines (e.g. predators like coyotes in a national park where hunting is prohibited) (Ward et al., 2018). For this reason, systems that demonstrate powerful resistance to threat are, paradoxically, often made vulnerable by their success.
Circ_0068087 knockdown attenuates high‐glucose‐induced human tubular epithelial cell injury in a microribonucleic acid/progestin and adipoQ receptor 3‐dependent manner in diabetic nephropathy
Authors: Liu Shu‐yan , Wang Hong , Yang Bo , Hou Baohua , Sun Li‐sha , Pang Hui , Wang Hui‐hui , Fan Yan‐ping 
Published: November 2023

AbstractAims/IntroductionPrevious studies have shown that circular ribonucleic acid mediates the occurrence of diabetic nephropathy. This study aimed to analyze the effects of circ_0068087 on high‐glucose (HG)‐induced human kidney 2 (HK2) cell dysfunction.Materials and MethodsCirc_0068087, miR‐580‐3p, and progestin and adipoQ receptor 3 (PAQR3) expression were detected by quantitative reverse transcription polymerase chain reaction. Cell viability and proliferation were investigated by Cell Counting Kit‐8 and EdU assays, respectively. The cell apoptotic rate was assessed by flow cytometry. Inflammatory response was assessed by enzyme‐linked immunoassays. Oxidative stress was evaluated by a superoxide dismutase activity assay kit and lipid peroxidation malondialdehyde assay kit. Molecular interaction was identified by dual‐luciferase reporter assay.ResultsCirc_0068087 and PAQR3 expression were significantly upregulated in diabetic nephropathy patients. HG treatment inhibited HK2 cell proliferation, but induced cell apoptosis, inflammation, oxidative stress and epithelial–mesenchymal transition by regulating circ_0068087. Circ_0068087 acted as a microribonucleic acid‐580‐3p (miR‐580‐3p) sponge, and miR‐580‐3p targeted PAQR3. Furthermore, circ_0068087 depletion repressed PAQR3 expression through miR‐580‐3p. MiR‐580‐3p inhibitors or PAQR3 introduction attenuated circ_0068087 silencing mediated‐effects in HG‐treated HK2 cells.ConclusionCirc_0068087 promoted HG‐induced HK2 cell injuries by the regulation of the miR‐580‐3p/PAQR3 pathway.
The dam that fly ash built
Authors: Montgomery Amy , Kasaniya Mahipal , Zhao Pengfei , Thomas Michael , Peterson Karl 
Published: November 2023

AbstractWhen the first concrete was poured in 1949 for the Hungry Horse Dam (Montana, USA), pozzolan cements had already been used in several major North American dams, including Grand Coulee on the Columbia River (diatomaceous earth explored but ultimately not used), Friant on the San Joaquin River and Altus on the North Fork Red River (pumicite) and Bonneville on the Columbia River and Davis on the Colorado River (calcined clay). But Hungry Horse Dam stands out as the first dam constructed using coal combustion fly ash. Utilising 2.4 million cubic metres of concrete, the dam is located on the South Fork Flathead River, one of the tributaries feeding one of the nation's major waterways, the Columbia River, and closely related to the adjacent Glacier National Park. In this respect, Hungry Horse is directly connected to two momentous periods in modern history – the massive adoption in the 1950s of coal as fuel for power plants, and the ongoing threats to fresh water supply and the rapid retreat of alpine glaciers due to global warming. Two concrete cores from this dam, one with fly ash and one without fly ash, are examined microscopically to explore the long‐term suppression of alkali‐aggregate reaction by fly ash. The core without fly ash exhibits clear evidence of alkali‐aggregate reaction, manifested by sandstone coarse aggregate particles with darkened reaction rims. Sandstone coarse aggregate particles of the same lithology in the core with fly ash are without signs of alkali‐aggregate reaction. A detailed examination of the darkened rims indicates that alkali‐silica reaction products fill the narrow gaps between adjacent sand grains in the sandstone. This alkali‐silica gel infilling allows for optical continuity between adjacent sand grains and is responsible for the classic darkened rim associated with the alkali‐aggregate reaction.
Vulvar squamous cell carcinoma in a captive female chimpanzee: A case report
Authors: Alpízar Aide , Fajardo Raul , Martínez José Simón , Ortega Cesar 
Published: November 2023

AbstractA necropsy was performed on a 43‐year‐old female zoo chimpanzee, with cancer in the vulvar and perivulvar region. She was diagnosed with squamous cell carcinoma, the presence of this tumor in domestic animals and non‐human primates is very rare in the vulvar region and there were no previous reports found on it in chimpanzee, due to which this report contributes to the knowledge on chimpanzee pathologies.
Key stakeholders' perspectives: A gap analysis of hospital‐acquired pressure injuries
Authors: Riley Bettina H. , Pittman Joyce , Otts Jo Ann A. , Mulekar Madhuri S. 
Published: November 2023

AbstractIntroductionHospital‐acquired pressure injuries (HAPIs) are a global high‐stakes patient safety issue. Key stakeholder perspectives regarding their role and experiences with pressure injuries is critical as part of the solution to minimizing HAPI occurrence and attain sustainability.DesignA qualitative, descriptive approach provided multiple perspectives of key stakeholders to support the complexity of HAPI care. The qualitative data are a part of a mixed method convergent research study examining pressure injury prevention and management practices.MethodsNursing system theory, mixed method convergent design, and participatory action research methodologies were chosen to address both the gap analysis development and results, achieve collaborative comprehensiveness, and enable key stakeholder involvement throughout this HAPI prevention and management initiative. Participants were recruited and enrolled from a large Level I trauma hospital and the key stakeholders. Demographic information were collected prior to the individual interview. Focused interviews were conducted virtually using zoom technology. Qualitative data were analyzed using NVivo software and thematic analysis was confirmed across the co‐investigators for congruence and applicability to the research questions.ResultsQualitative interviews with 26 key stakeholders provided data to support and integrate a link with gap analysis results on the complex health issue of HAPIs. Specific barrier and recommendation themes identified interventions that could be prioritized. The 52 barrier and 52 recommendation themes/sub‐theme(s) respectively were organized by Donabedian (structure, process, and outcome) with structure elements the majority. The top three structure barrier themes involved equipment and standards for use, staff prevention education, and specialized health professionals. The top three structure recommendation themes involved specialized health professionals, equipment and standards for use, and an educational plan for those at risk or with HAPIs.ConclusionThe article provides findings from the qualitative portion of a mixed method study related to HAPIs. The qualitative findings associated with the gap analysis quantitative results, achieved the goal of the participatory action research key stakeholders' input into HAPI care and can be replicated internationally.Clinical RelevanceThe benefit of key stakeholder's involvement in solving a clinical problem is sustainability. A quantitative approach and integrating qualitative stakeholders' perspectives provide an in‐depth solution that will advance nursing capacity toward health care delivery and HAPI nursing science and policy development on a global level.
Data‐independent acquisition for proteomic applications in early‐stage endometrial cancer progression
Authors: Cheng Yuemei , Xing Yijuan , Du Junhong , Hu Dan , Liang Xiaolei , Liu Chang , Yang Yongxiu 
Published: November 2023

AbstractAimMost endometrial cancer (EC) patients are diagnosed at an early‐stage (FIGO stage I or II), with a favorable prognosis. However, some high‐grade, early‐stage EC patients have unexpected recurrences and undesirable results, the molecular alterations that underlie these tumors are far from being fully understood. Our goal was to use proteome analysis to examine dysregulated pathways in this specific subgroup of EC.MethodsWe used data‐independent acquisition (DIA) quantitative proteomics to analyze cancer and matched paracancerous tissues from 20 EC patients (10 high‐grade and 10 low‐grade). Immunohistochemistry (IHC) analysis was used to validate protein expression of six hub genes.ResultsIn total, 7107 proteins were quantified, while 225 downregulated and 366 upregulated proteins in high‐grade cancer tissues, 130 downregulated and 413 upregulated proteins in high‐grade paracancerous tissues. The pathway associated with oxidative phosphorylation (OXPHOS) was upregulated and have similar expression patterns in high‐grade EC tissues and matched paracancerous tissues. OXPHOS‐related protein, ATP5F1D showed the best classification and diagnostic ability in distinguishing high‐grade from low‐grade EC. In both cancer and paracancerous tissues, double‐label immunofluorescence demonstrated ITGA4 and COL4A1 co‐localized at the basal membrane.ConclusionsOur present works elucidate that metabolism reprogramming is associated with high‐grade, early‐stage EC, particularly OXPHOS is upregulated. Noticeably, the paracancerous tissues have undergone molecular changes similar to cancer tissues, maybe they have signal exchange via secreted proteins (ITGA4 and COL4A1). The upregulation of OXPHOS‐related proteins may be the potential biomarker for EC diagnosis, and targeting OXPHOS metabolism might be an effective treatment for high‐grade, early‐stage EC.
Microaggressions, perceptions of campus climate, mental health, and alcohol use among first‐year college students of color
Authors: Samek Diana R. , Crumly Brianna , Akua Bruno Ache , Dawson Mary , Duke‐Marks Adrienne 
Published: November 2023

AbstractDepressive and anxiety symptoms are increasingly common, and problematic alcohol use remains prevalent in college. To expand on prior research on mostly white samples, we surveyed first‐year students of color from our predominately white university (Southeastern US) to identify risk factors for mental health symptoms and potentially co‐occurring problematic alcohol use. Results showed significant associations between microaggressions and poor campus climate (hypothetical predictors) with depressive, anxiety, somatic symptoms (hypothetical outcomes) that were indirectly linked through perceived stress, poor sleep, and academic burnout (hypothetical mediators). Poor campus climate, academic burnout, and using alcohol to cope were the most relevant to alcohol use disorder symptoms. Results support efforts to address and reduce racial microaggressions and promote a positive campus climate for all.
The impact of rural general hospital closures on communities—A systematic review of the literature
Authors: Mills Carol A. , Yeager Valerie A. , Unroe Kathleen T. , Holmes Ann , Blackburn Justin 
Published: November 2023

AbstractPurposeTo compile the literature on the effects of rural hospital closures on the community and summarize the evidence, specifically the health and economic impacts, and identify gaps for future research.MethodsA systematic review of the relevant peer‐reviewed literature, published from January 2005 through December 2021, included in the EMBASE, CINAHL, PubMed, EconLit, and Business Source Complete databases, as well as “gray” literature published during the same time period. A total of 21 articles were identified for inclusion.FindingsOver 90% of the included studies were published in the last 8 years, with nearly three‐fourths published in the last 4 years. The most common outcomes studied were economic outcomes and employment (76%), emergent, and non‐emergent transportation, which includes transport miles and travel time (42.8%), access to and supply of health care providers (38%), and quality of patient outcomes (19%). Eighty‐nine percent of the studies that examined economic impacts found unfavorable results, including decreased income, population, and community economic growth, and increased poverty. Between 11 and 15.7 additional minutes were required to transport patients to the nearest emergency facility after closures. A lack of consistency in measures and definition of rurality challenges comparability across studies.ConclusionsThe comprehensive impact of rural hospital closures on communities has not been well studied. Research shows predominantly negative economic outcomes as well as increased time and distance required to access health care services. Additional research and consistency in the outcome measures and definition of rurality is needed to characterize the downstream impact of rural hospital closures.
Pharmacokinetics of gamma‐hydroxybutyric acid in 6‐week‐old swine (Sus scrofa domesticus) after intravenous and oral administration
Authors: Cuypers Charlotte , Devreese Mathias , Van Uytfanghe Katleen , Stove Christophe , Schauvliege Stijn 
Published: November 2023

AbstractSedative as well as protective effects during hypoxia have been described for gamma‐hydroxybutyric acid (GHB). Six swine (Sus scrofa domesticus) of 6 weeks old were administered NaGHB at a dose of 500 mg/kg intravenously (IV) and 500 and 750 mg/kg orally (PO) in a triple cross‐over design. Repeated blood sampling was performed to allow pharmacokinetic analysis of GHB. Whole blood concentration at time point 0 after IV administration was 1727.21 ± 280.73 μg/mL, with a volume of distribution of 339.45 ± 51.41 mL/kg and clearance of 164.94 ± 47.05 mL/(kg h). The mean peak plasma concentrations after PO administration were 326.57 ± 36.70 and 488.01 ± 154.62 μg/mL for 500 mg/kg and 750 mg/kg, respectively. These were recorded at 1.42 ± 0.72 and 1.58 ± 0.58 h after PO dose for GHB 500 mg/kg and 750 mg/kg, respectively. The elimination half‐life for IV and PO 500 mg/kg and PO 750 mg/kg dose was respectively 1.33 ± 0.30, 1.16 ± 0.31 and 1.11 ± 0.33 h. The bioavailability (F) for PO administration was 45%. No clinical adverse effects were observed after PO administration. Deep sleep was seen in one animal after IV administration, other animals showed head pressing and ataxia.
Effect of neuromuscular electrical stimulation and early physical activity on ICU‐acquired weakness in mechanically ventilated patients: A randomized controlled trial
Authors: Othman Sahar Younes , Elbiaa Maysa Abdalla , Mansour Eman R. , El‐Menshawy Ahmed M. , Elsayed Shimmaa Mohamed 
Published: November 2023

AbstractBackgroundIntensive care unit‐acquired weakness (ICU‐AW) is common in critically ill patients and increases the duration of mechanical ventilation (MV) and weaning time. Early mobilization, range of motion (ROM) exercises, and neuromuscular electrical stimulation (NMES) can prevent ICU‐AW by maintaining muscle mass. However, studies highlighting the effects of combining NMES with early physical activity in ICU patients are limited.AimTo evaluate the effect of NMES and early physical activity on ICU‐AW in mechanically ventilated patients.Study DesignA single‐blinded randomized controlled trial was conducted in Alexandria, Egypt. Patients were randomly assigned to one of four groups: NMES, ROM, combined therapy (ROM + NMES), or conventional care (control group). The Medical Research Council (MRC) scale was used to assess the ICU‐AW for the study patients over a 7‐day period. The duration of the patient's MV and ICU stays were recorded.ResultsOf the 180 patients who were assessed for eligibility, 124 were randomly assigned to one of four groups: 32 patients in ROM exercises, 30 in NMES, 31 in combined therapy (ROM + NMES), and 31 in the control group. On day 7, ROM + NMES and NMES groups showed higher MRC scores than ROM and control groups (50.37 ± 2.34, 49.77 ± 2.19, 44.97 ± 3.61, and 41.10 ± 3.84, respectively). ANOVA test results indicated significant differences (p < .001) across the four groups. ICU‐AW occurred in 0% of the ROM + NMES group, 60% of the ROM group, 13% of the NMES group, and 100% of the control group (p < .001). The MV duration (in days) in the ROM + NMES group was shorter (12.80 ± 3.800) than in the ROM, NMES, or control groups (21.80 ± 4.460, 18.73 ± 4.748, and 20.70 ± 3.932, respectively). ICU‐LOS was shorter in the ROM + NMES group (17.43 ± 3.17 days) compared with the ROM group (22.53 ± 4.51 days), the NMES group (21.10 ± 5.0 days), and the control group (21.50 ± 4.42 days) with significant differences (p < .001) between the four groups.ConclusionDaily sessions of NMES and early physical activity were well tolerated, preserved muscle strength, prevented ICU‐AW, and decreased the duration of the MV and ICU stay.Relevance to Clinical PracticeThe findings of this study support the use of NMES and early physical exercises by critical care nurses as part of routine care for critically ill patients.
Aristolochia mimics stink bugs to repel vertebrate herbivores via TRPA1 activation
Authors: Yu Yu‐Long , Ge Jia , Dong Wen‐Qi , Chomicki Guillaume , Yang Shi‐Long , Geng Yupeng , Chen Gao 
Published: November 2023

Summary
Mimicry is the phenomenon in which one species (the mimic) closely resembles another (the model), enhancing its own fitness by deceiving a third party into interacting with it as if it were the model. In plants, mimicry is used primarily to gain fitness by withholding rewards from mutualists or deterring herbivores cost‐effectively. While extensive work has been documented on putative defence mimicry, limited investigation has been conducted in the field of chemical mimicry.
In this study, we used field experiments, chemical analyses, behavioural assays, and electrophysiology, to test the hypothesis that the birthwort Aristolochia delavayi employs chemical mimicry by releasing leaf scent that closely resembles stink bug defensive compounds and repels vertebrate herbivores.
We show that A. delavayi leaf scent is chemically and functionally similar to the generalized defensive volatiles of stink bugs and that the scent effectively deters vertebrate herbivores, likely through the activation of TRPA1 channels via (E)‐2‐alkenal compounds.
This study provides an unequivocal example of chemical mimicry in plants, revealing intricate dynamics between plants and vertebrate herbivores. Our study underscores the potency of chemical volatiles in countering vertebrate herbivory, urging further research to uncover their potentially underestimated importance.
Psychedelia: The interplay of music and psychedelics
Authors: Jerotic Katarina , Vuust Peter , Kringelbach Morten L. 
Published: November 2023

AbstractMusic and psychedelics have been intertwined throughout the existence of Homo sapiens, from the early shamanic rituals of the Americas and Africa to the modern use of psychedelic‐assisted therapy for a variety of mental health conditions. Across such settings, music has been highly prized for its ability to guide the psychedelic experience. Here, we examine the interplay between music and psychedelics, starting by describing their association with the brain's functional hierarchy that is relied upon for music perception and its psychedelic‐induced manipulation, as well as an exploration of the limited research on their mechanistic neural overlap. We explore music's role in Western psychedelic therapy and the use of music in indigenous psychedelic rituals, with a specific focus on ayahuasca and the Santo Daime Church. Furthermore, we explore work relating to the evolution and onset of music and psychedelic use. Finally, we consider music's potential to lead to altered states of consciousness in the absence of psychedelics as well as the development of psychedelic music. Here, we provide an overview of several perspectives on the interaction between psychedelic use and music—a topic with growing interest given increasing excitement relating to the therapeutic efficacy of psychedelic interventions.
Refractive extended depth‐of‐focus lens design based on periodic power profile for presbyopia correction
Authors: Lyu Jiakai , Bang Seung Pil , Yoon Geunyoung 
Published: November 2023

AbstractPurposeLimitations of existing diffractive multifocal designs for presbyopia correction include discrete foci and photic phenomena such as halos and glare. This study aimed to explore a methodology for developing refractive extended depth‐of‐focus (EDoF) lenses based on a periodic power profile.MethodsThe proposed design technique employed an optical power profile that periodically alternated between far, intermediate and near distances across the pupil radius. To evaluate the lens designs, optical bench testing was conducted. The impact on visual performance was assessed using a spatial light modulator‐based adaptive optics vision simulator in human subjects. Additionally, the effects of pupil size change and lens decentration on retinal image quality were examined. A comparative performance analysis was carried out against a typical diffractive trifocal design and a monofocal lens.ResultsThe proposed design method was found to be effective in uniformly distributing light energy across all object distances within the desired depth of focus (DoF). While trade‐offs between overall image quality and DoF still exist, the EDoF lens design, when tested in human subjects, provided a continuous DoF spanning over 2.25 D. The results also revealed that the EDoF design had a slightly higher dependence on changes in pupil size and lens decentration than the diffractive trifocal design.ConclusionThe proposed design method showed significant potential as an approach for developing refractive EDoF ophthalmic lenses. These lenses offer a continuous DoF but are slightly more susceptible to variations in pupil size and decentration compared with the diffractive trifocal design.
Development and validation of a predictive model for persistent opioid use in new opioid analgesic users via a nationwide claims database
Authors: Noh Yoojin , Heo Kyu‐Nam , Cho Won Bean , Lee Ju‐Yeun , Ah Young‐Mi 
Published: November 2023

AbstractBackgroundChronic opioid use is associated with problematic opioid use, such as opioid abuse. It is important to develop a prediction model for safe opioid use. In this study, we aimed to develop and validate a risk score model for chronic opioid use in opioid‐naïve, noncancer patients, using data from a nationwide database.MethodsData from the National Health Insurance Claims Database in the Republic of Korea from 2016 to 2018 were used, and adult, noncancer patients who were started on non‐injectable opioid analgesics (NIOAs) were included. The risk score model was developed using the β coefficient of each variable in the multivariable logistic regression analysis.ResultsOverall, 676,676 noncancer patients were started on NIOAs, of which 65,877 (9.7%) were prescribed NIOAs chronically. Age, baseline healthcare utilization, comorbidities, co‐medications, and pattern of first NIOA prescription were identified as risk factors for chronic opioid use. The c‐static for the performance of our risk score model was 0.754 (95% confidence interval, 0.750–0.758).ConclusionTo our knowledge, this is the first tool that can predict chronic opioid use in the Korean population. The model can help physicians examine the risk of chronic opioid use by patients who are started on NIOA.