bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term mortality in different COVID-19 variants: 18-month follow-up
Authors: Lakman I. A. , Gareeva D. F. , Sadikova L. F. , Agapitov A. A. , Davtyan P. A. , Kayumova V. L. , Timiryanova V. M. , Zagidullin N. Sh. 
Published: December 2023

The viral infection and pandemic of coronavirus infection 2019 (COVID-19) was characterized not only by high morbidity and in-hospital mortality, but also by an increase in the mortality of patients after hospital discharge. At the same time, differences were noted in hospitalization rate, the number of complications and mortality of patients, and mortality rate between different pandemic waves from 2020 to 2023.Aim. To compare the 18-month post-hospital mortality rate of patients between three COVID-19 variants (Alpha, Delta and Omicron).Material and methods. In this prospective, single-center, non-randomized continuous study, 2400 medical records of patients with the Alpha variant (2020), 1826 with the Delta variant (2021) and 997 with the Omicron variant (2022) were analyzed. The end point was all-cause mortality during the follow-up period.Results. There were following differences in clinical and demographic characteristics in the context of COVID-19 strains: more women were hospitalized in the Delta and Omicron waves; in the Omicron wave, patients were older. Also, comorbid patients were more common with the Delta and Omicron variants than with the Alpha (in chronic obstructive pulmonary disease, hypertension and heart failure), but chronic kidney disease was more common with the Alpha and Omicron variants. The groups differed significantly in mortality, with the maximum being with Delta and the minimum with Omicron, and the maximum mortality with Delta was observed in the first 90 days after discharge. Between 12 and 18 months, survival estimates decreased most for patients hospitalized in the Delta wave, which is determined by the risk of long-term cardiovascular consequences.Conclusion. Clinical and demographic differences between patients with different COVID-19 variants, as well as a significant difference in the mortality rate of patients of different waves, emphasize the importance of a personalized approach to treatment and long-term post-hospital monitoring.
Batı Akdeniz’deki ekstrem kuraklık şartlarının SPEI yöntemiyle belirlenmesi
Authors: DURMUŞ Barış , BULUT İhsan 
Published: December 2023

ÖZ
Doğal ve beşeri ekosistemler açısından karmaşık etkilere sahip olan kuraklıklar, genel olarak uzun süreli yağış eksikliği şeklinde tanımlanan ve oldukça tehlikeli sonuçları olan bir afet türüdür. İklim değişikliği ile birlikte artan sıcaklık ve yağış değişkenlikleri, kuraklık olaylarının sıklığı, şiddeti ve süresini değiştirmektedir. Artan sıcaklıklar ile birlikte bir sıcak nokta haline gelen Akdeniz Havzası, bu fenomen karşısında oldukça kırılgan hale gelmiştir. Bu çalışmada, ülkemizin Batı Akdeniz kesimi için temin edilen 1980-2019 yılları arasındaki günlük sıcaklık ve yağış verileri kullanılarak, Standartlaştırılmış Yağış Evapotranspirasyon İndisi (SPEI) yardımıyla ekstrem kurak dönemler 3-6-12 aylık ölçeklerde araştırılmıştır. Hesaplamalarda yağış faktörünün yanında, sıcaklık ve buharlaşma faktörlerini de birleştiren SPEI yönteminin, ekstrem kurak dönemleri belirlemede başarılı olduğu gözlemlenmiştir. Elde edilen sonuçlara göre; SPEI-3 ve SPEI-6 aylık zaman serilerinde 1981, 1985, 1989, 1990, 2000, 2007 ve 2008 yılları; SPEI-12 aylık zaman serilerinde ise 1990-1991, 2000-2001, 2004-2005, 2007-2008 ve 2016 yılları ortak ekstrem kurak yıllar olarak tespit edilmiştir. 3 ve 6 aylık ekstrem kuraklıkların genel olarak yaz ve sonbahar aylarında gerçekleştiği belirlenmiştir. Ekstrem kurak ayların en fazla tespit edildiği istasyon olan Burdur’da, 2015 ve 2018 yılları arası şiddetli şekilde kurak geçmiştir. Genel olarak, kıyı kesimlerde nemli olma eğilimi, iç kesimlerde ise kuraklaşma eğilimleri tespit edilmiştir. Özellikle iç kesimlerde tarımsal sürdürülebilirlik ve su yönetimi üzerine yapılacak çalışmalar, şiddetli kuraklık şartlarına karşı adaptasyon ve zararları azaltmak açısından oldukça önemlidir.
Comportamiento del consumidor de food delivery apps en la Ciudad de Puebla, México
Authors: Moreno Cortés Karla Coré , Morales Paredes Yesbek Rocio , Romano Cadena María Martha del Socorro , Cerón Carrillo Teresa Gladys 
Published: December 2023

El negocio de las delivery apps para el ramo de alimentos y bebidas representa una idea funcional con alto crecimiento en y para el sector.
La metodología de esta investigación fue cuantitativa, no experimental y correlacional, el objetivo del trabajo fue valorar los cambios que se dieron en el consumo de alimentos y bebidas en establecimientos de alimentos y bebidas de la Ciudad de Puebla, a partir del análisis post-pandémico del uso de las delivery apps, para proponer estrategias que puedan aportar innovación al sector. El resultado más importante que se obtuvo fue la correlación significativa entre la edad y el uso de las delivery apps, así como entre la cercanía (minutos de distancia) entre los establecimientos y uso de las delivery apps. A partir de los resultados, se propone la creación de una alianza estratégica tipo cluster entre los establecimientos que se ubican dentro de una misma zona comercial.
Estudio morfológico de un caso de hermafroditismo en Procambarus clarkii (crustáceo, decápodo) de la Albufera de VAlencia
Authors: Soler Carles , Ferrando María Dolores , Almar Galiana Maríamar 
Published: December 2023

Hemos recogido y revisado aproximadamente 7000 ejemplares de a especie Procambarus clarkii y de todos ellos sólo uno era aparentmente hermafrodita. Este animal se examinó y sus gónadas se fijaron en solución Bouin durante dos horas. El lóbulo genital posterior presentaba en su zona proximal tejido ovárico alterado y en su zona distal acinos testiculares inactivos. Por ello, este anima puede considerarse como un caso de hermafroditismo auténtico en esta especie
Biological fixation of customized implants for post-traumatic acetabular deformities and defects
Authors: Bazlov V. A. , Pronskikh A. A. , Korytkin A. A. , Mamuladze T. Z. , Efimenko M. V. , Pavlov V. V. 
Published: December 2023

Introduction The number of surgical interventions using additive technologies in medicine has been growing both in Russia and with every year. Due to the development of printing customized implants, the use of standard (imported) designs has decreased by an average of 7 % in the provision of high-tech medical care. However, the issue of the pore size of customized implants for management of post-traumatic defects in the acetabulum remains open.Objective To evaluate the results of the treatment of patients with post-traumatic acetabulum defects and deformities with the implementation in clinical practice of customized implants with structure and size porous surface that are optimal from the point of view of biological fixation.Material and methods Porous implants with different types of porous structure were produced by direct laser sintering using Ti-6Al-4V titanium alloy powders. Experimental work was carried out in vitro to determine the ability of living fibroblasts to penetrate the pores of different sizes. Next, the clinical part of this study was conducted in order to determine the signs of biological fixation of customized acetabular implants in a group of patients (n = 30).Results The results of this experiment performed to analyze the penetration of living fibroblasts into the porous structure of implants with different pore size demonstrated that metal structures with a pore size of 400-499 μm can be singled out from all others. Discussion Analysis of the literature data shows that there is no consensus on the structure and size of the pores of a customized implant. In our work, we investigated the ability of human living fibroblasts to penetrate into the surface structure of a customized implant, as a result of which we determined their optimal pore size of 400-499 microns. It should be noted that this study was conducted for a definite anatomical location: the acetabulum. However, it cannot be excluded that the data obtained are relevant for other anatomical locations.Conclusion Management of bone defects in the acetabulum area with customized implants featuring the surface pore size of 400-499 microns is a justified and relevant method. A prerequisite for the use of such implants is strict compliance with the indications for their use, careful preoperative planning and correct positioning.
Resorbable implants in paediatric orthopaedics and traumatology
Authors: Lascombes P. , Journeau P. , Popkov D. A. 
Published: December 2023

Background Development of resorbable implants for paediatric orthopaedics is promising as there is no need for implant removal.The aim of this paper is to present our experience in resorbable implants in paediatric traumatology, and to make an overview of the recent literature.Material and methods In our department of paediatric traumatology and orthopaedics, we have operated 7 children with fractures of long bones with resorbable screws (ActivaScrew™). The inclusion criteria were intra-articular and juxta-articular fractures in children with an indication for screw fixation. To prepare the review, we searched for information sources at the scientific platforms such as PubMed, Scopus, ResearchGate, RSCI, as well as other published products (Elsevier, Springer).Results The cohort is represented by 7 patients, 4 girls and 3 boys, aged from 5 to 14 years old. The 7 fractures were 3 at the elbow and 4 at the ankle joint. In the immediate postoperative period, no patient presented with abnormal swelling, redness, or tissue reaction. Pain disappeared at day 7 in all cases. Weight-bearing and return to sport activities were allowed in normal delay. Radiological bone union was obtained between 3 and 6 weeks. Range of motion in adjacent joints was comparable to the opposite non-fractured side at 3 months. There were no cases of complications, no infection, and no need for a reoperation.Discussion The use of resorbable implants, either co-polymers or magnesium, solves the problem: removal of implants is not anymore necessary. Resorbable implants are becoming safer as they have good solidity allowing bone union of fractures and osteotomies before their eliminating.Conclusion Main indications of resorbable implants in pediatrics remain fractures and osteotomies fixed with screws. The development of plates and intramedullary nails will enlarge the indications. Level of evidence: IV.
Biocompatible implants in orthopedics: bone tissue engineering
Authors: Popkov A. V. , Popkov D. A. 
Published: December 2023

Introduction Technological advances in bone tissue engineering have improved orthopaedic implants and surgical techniques for bone reconstruction. This approach allows overcoming inconvenience of the paucity of autologous materials available and donor site morbidity.Aim To demonstrate advances of the past 30 years in the development of bioimplants providing alternatives to bone grafting in reconstructive orthopaedics.Methods Preparing the review, the scientific platforms such as PubMed, Scopus, ResearchGate, RSCI were used for information searching. Search words or word combinations were bioactive osteoinductive implants, bone grafting, bone reconstruction, hydroxyapatite, bone scaffolds.Results The main trends in tissue engineering in the field of orthopaedics are represented by construction of three-dimensional structure implants guiding cell migration, proliferation and differentiation as well as mechanical support. Association with bone morphogenetic proteins, growth factors enables proliferation and differentiation of cell types of the targeted bone tissue. A promising advancement should be biodegradability with a controllable degradation rate to compliment cell/tissue in-growth and maturation in limb reconstruction.Discussion This review presents and discusses the experimental and clinical application of biotolerant, bioinert and bioactive materials for reconstructive bone surgery. Future generations of biomaterials are designed to be osteoconductive and osteoinductive.Conclusion Properties of polycaprolactone (PCL) filled with hydroxyapatite (from 10 to 50 wt %) make this hybrid material with controllable absorption a promising strategy for reconstructive surgery in comparison to other materials.
Regional models of import substitution processes in the context of modern economic realities (on the example of the Samara region)
Authors: Tyukavkin N. M. , Anisimova V. Yu. 
Published: December 2023

Purpose: is to develop regional import substitution models on the example of the Samara region.Methods: the paper uses a systematic approach, a method of evaluation and scientific abstractions, a method of classification and systematization, methods of information analysis and synthesis, a method of data visualization.Results: the author's toolkit of "innovative superiority of domestic products-an analogue of imported ones" has been developed, in the form of a complex of technological advantages available at the enterprise that are not available to others, forming the basis for rapid growth and development of innovations. The authors' hypothesis on the use by enterprises of the region of certain import substitution models based on the tools for the formation of innovative superiority of domestic products-an analogue of imported products, and tools for ensuring national security and overcoming anti-Russian sanctions on the production of products is put forward and proved. It is recommended to include measures to improve this policy, ensuring the development of the market of domestic products based on innovations. A program is proposed to implement for the development of national and regional innovation systems, the formation of regional and sectoral centers of innovation and technological development, the introduction of technologies of excellence and advanced development to ensure the development of the market of domestic industrial products on an innovative basis and meet domestic demand.Conclusions and Relevance: based on the analysis of the activities of industrial enterprises in the conditions of anti-Russian sanctions, it is concluded that regional policy should promote the production of competitive and innovative products, the introduction of energy and resource-saving technologies at industrial enterprises, and support the weakest enterprises with a high level of imported components. The authors of the proposed regional models of import substitution are presented by the interpretation of the really functioning regional models. In the approach proposed by the authors to the study of regional models of import substitution in industry, models of the scale and dynamics of these processes are substantiated, reflecting the production of products using domestic analogues of production, replacing imported technologies, using indicators of the domestic market, with further access to national and world markets.
Regional features of state financial support for small and medium-sized enterprises
Authors: Zaharova K. A. , Ivanova N. V. 
Published: December 2023

Purpose: of the article is to study the existing system of state financial support for small and medium-sized enterprises (SMEs) in the Tyumen Oblast in order to identify problematic points of SME development in the region and determine of appropriate measures for their adjustment.Methods:in the part of the study on the quantitative indicators of State financial support for SMEs, statistical analysis was used, including a study of the structure and dynamics of measures implemented, as well as the number of SMEs. To assess the degree of influence of the tools used on the development of SMEs, data from the ongoing program of state financial support in the Tyumen Oblast were used.Results: in the course of the research, the main determinants constraining the effectiveness of the use of State financial support tools for SMEs in the Tyumen Oblast were identified. The lack of systematic and comprehensive State financial support for SMEs was revealed, which would reflect the vision of the elements of the system and the establishment of the relationships between them, taking into account changes in the external environment and the indication of the most effective support measures for individual areas of SMEs activity.Сonclusions and Relevance: as a result of the study, the need to modernize the implemented state financial support for SMEs in the Tyumen Oblast in the direction of expanding the list of instruments and diversifying the measures applied to legal entities and individual entrepreneurs has been established. As one of the promising areas, it seems reasonable to create guaranteed sales markets and active connection of SMEs to business networks. This will maximize the effectiveness of measures applied to support economically and socially important SMEs, taking into account their specifics, strengthen the financial condition of enterprises in this sector and thus ensure the stability of the economic development of the region.
Project approach as a tool for the implementation of national projects in Russia
Authors: Kuznetsov N. V. , Pershina T. A. 
Published: December 2023

Purpose: of the presented research is to evaluate various methods of project management, including methodological approaches already used in our country, for their application in the implementation of national projects of the Russian Federation.Methods: the work used traditional methods of scientific theoretical analysis, including system analysis, as well as an induction approach.Results: the authors consider the historical aspect of the formation of the project approach as a method used in the professional field of management. In the work, various management approaches presented by different countries were studied and systematized. The analysis of project management experience in the leading countries of the world, as well as in the Russian Federation, was carried out. The study presents the use of the project approach in the implementation of national projects, an assessment of the work of the project implementation monitoring system is given. Based on the identified methodological and organizational problems in the formation of new and implementation of current national projects in Russia, the authors conclude that it is necessary to improve project management methods and monitoring the achievement of performance indicators of national projects.Conclusions and Relevance: the specifics of public administration in Russia require the development of their own design methods in the management system, which will only rely on those already created in the world, but not copy them completely. So, according to the authors, the best practice will be the use of flexible management methods. Existing methodologies and individual strategies of other countries can only help in developing ideas for both the general concept of the implementation of existing national projects and for designing new ones.
Farklı yöntemlerle tedavi edilen erozyonlu mine yüzeyine uygulanan ortodontik braketlerin bağlanma dayanımlarının karşılaştırılması
Authors: TEKELİ Alaattin , GÖRGÜLÜ Serkan , ALAKUS SABUNCUOGLU Fidan , DURAN Gökhan Serhat 
Published: December 2023

Amaç: Çalışmanın amacı ortodontik braketlerin, dört farklı remineralizasyon ajanı ile işlenmiş demineralize mineye bağlanma dayanımının (Shear Bond Strength- SBS) değerlendirmesi ve taramalı elektron mikroskobu (SEM) kullanarak mine yüzeylerinin incelenmesidir.
Gereç ve Yöntemler: Bu in vitro çalışmada, 120 premolar diş incelenmiştir. Premolar dişler 20’şer dişin olduğu altı gruba ayrıldı: negatif kontrol (Grup NC)- herhangi bir tedavi ajanı uygulanmadan erozyon remineralizasyon döngüsü uygulanan grup, pozitif kontrol (Grup PC), florür ile tedavi edilen grup (Grup F), kombinasyon halinde florür ve diyot lazer ile tedavi edilen grup (Grup F+D), CPP-ACP ile tedavi edilen grup (Grup M) ve nano-hidroksiapatit ile tedavi edilen grup (Grup B). PC grubu hariç tüm örneklerde erozyon remineralizasyon döngüsü uygulandı. Her bir grup için 20 örnek, yapışma dayanımı SBS testine tabi tutuldu ve SEM kullanılarak incelendi.
Bulgular: Ortodontik braketlerin SBS değerleri açısından gruplar arasında istatistiksel olarak anlamlı fark tespit edildi (p˂0.001). Grup M ve Grup B arasında istatistiksel olarak anlamlı bir fark bulunmamaktaydı (p = 0.375). Diğer tüm ikili karşılaştırmalarda önemli bir fark vardı (p˂0.001). Grupların erozyon remineralizasyon döngüsü sonrasında uygulanan ortodontik braketlerin SBS değerleri sırası şu şekildeydi; Grup NC (sağlam mine)> Grup B ~ Grup M> Grup F+D> Grup F> Grup PC (erozyona uğramış mine). SEM incelemeleri SBS bulgularını destekler niteliteydi.
Sonuç: Çalışmamızdaki tüm gruplara uygulanan remineralizasyon materyallerinin, erozyona uğramış diş yüzeylerinin yapışma dayanım değerlerini önemli ölçüde arttırdığı belirlendi. Grup M ve Grup B, demineralize mine yüzeylerine ortodontik braketlerin yapıştırılması için klinik olarak kabul edilebilir SBS değerleri sağlama konusunda diğer gruplardan daha etkili bulundu.
Feeding up and Feeding Back: Exploring the Value of Peer Learning through a Law Clinic setting
Authors: Hewitt Louise , Yeatman Lucy 
Published: December 2023

Students continually have conversations about what they are learning in their studies. Often without realising it, they take part in peer learning though the process of getting stuck on a problem and asking another student about it. The conversation that follows is part of the learning experience where both students work to understand and resolve the issue, sharing the burden and making it enjoyable. Whilst there is undoubtedly a benefit in peer learning, replicating the informal conversations between students in a structured learning environment can be daunting to teachers and students alike. We are two law clinicians in two very different law clinic settings. Our previous reflections on our use of feedback led us to recognise it as a form of communication, which builds upon a foundation of good relationships and an atmosphere of trust in our teaching spaces. It is in this learning environment that we have seen peer learning take place with our students, in the form of peer review and peer feedback with positive results: peer review has led to discussions about what constitutes a good piece of work and to take ownership of the cases they are working on, and peer feedback has supported a process of evaluation in the context of assessing whether the work is of the professional standard required. This study explores the value of peer learning, evaluating what students working in our law clinics actually think about it. Drawing upon our experience of small group face to face teaching we will look at the impact of remote learning resulting from Covid 19 on the student experience, and how students manage to develop and sustain peer learning. Understanding whether peer learning is considered useful, or whether the distrust towards peer review and peer feedback in particular remains, will, we hope, lead to more discussions about how peer learning can be developed in a variety of teaching spaces.