bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring Over a Decade in the Serotype Prevalence of Streptococcus pneumoniae in Iran: A Systematic Review and Meta-analysis
Authors: Mamishi Setareh , Pourakbari Babak , Bahador Abbas , Sadeghi Reihaneh Hosseinpour , Pourhajibagher Maryam 
Published: November 2023

Background:
There is no comprehensive information about the circulating serotypes of
Streptococcus pneumoniae in Iran in recent years. This study aimed to summarize information about
the changes over a decade in the serotype prevalence of S. pneumoniae in Iran.

Methods:
We performed a comprehensive search in PubMed/Medline, Web of Science, Science
Direct, and the Iranian Database, such as Magiran and SID, from January 2011 to February 2023.
The systematic process, in accordance with the Preferred Reporting Items for Systematic Reviews
and Meta-Analyses (PRISMA), was carried out by two researchers who were both independent and
calibrated. Statistical analyses were carried out using Comprehensive Meta-Analysis software. Identifying
and measuring heterogeneity were done using I2 and the chi-square test. Finally, Begg’s rank
correlation test was used in combination with a funnel plot to evaluate any possible publication bias.

Results:
The search returned 16 relevant results, with a total of 1575 isolates. Of those studies, eight
studies reported the distribution of S. pneumoniae serotypes among patients, three studies among
healthy individuals, and five studies among both groups. As the meta-analysis revealed, the most
common serotypes were 23F (n = 299, 14.1% [95% CI: 9.7-19.9]; I2 = 84.3%; P<0.001 for heterogeneity),
19F (n = 221, 13.4% [95% CI: 9.9-17.9; I2 = 76.7%; P<0.001 for heterogeneity]), and 19A
(n = 102, 8.7% [95% CI: 6.5-11.7; I2 = 54.3%; P<0.001 for heterogeneity]). Moreover, Begg’s test
(P = 0.160, 0.173, and 0.176 for 23F, 19F, and 19A, respectively) showed no evidence of publication
bias.

Conclusion:
Based on our pooled results, the majority of the serotypes of pneumococci in the Iranian
population were 23F, 19F, and 19A, respectively, over the last decade. The findings can be valuable
in selecting effective pneumococcal vaccine candidates and targeted antibiotics in Iranian patients.
Enhanced Efficacy of Carvedilol by Utilization of Solid Dispersion and Other Novel Strategies: A Review
Authors: Rao Lakshita , Bhardwaj Bigul Yogeshver , Chugh Mahek , Sharma Ashish , Shah Rashmi , Minocha Neha , Pandey Parijat 
Published: November 2023

Abstract:Carvedilol is classified as a second class drug of Biopharmaceutical classification system (BCS), and it is an excellent beta blocker and vasodilating agent. It is used in a diverse range of disease states. Despite having tremendous advantages, the drug cannot be used effectively and productively due to aquaphobicity and poor bioavailability. To overcome this limitation, numerous novel approaches and tactics have been introduced over the past few years, such as Selfmicro emulsifying drug delivery systems (SMEDDS), nanoparticles, solid dispersions and liposomal drug delivery. The present review aims to accentuate the role of solid dispersion in improving the dissolution profile and aqua solubility of carvedilol and also to emphasize other novel formulations of carvedilol proposed to prevail the limitations of carvedilol. Solid dispersion and other novel approaches were found to play a significant role in overcoming the drawbacks of carvedilol, among which solid dispersion is the most feasible and effective approach being used worldwide. Reduced particle size, more wettability, and large surface area are obtained by the implementation of solid dispersion technique, hence improving carvedilol solubility and bioavailability
Assessing the Frequency of COVID-19 in Patients Undergoing Primary
Percutaneous Coronary Intervention (PCI)
Authors: Zahedi Mahdi , Davanloo Faezeh 
Published: November 2023

Background:
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global health crisis with significant morbidity and mortality

Objective:
The aim of this study was to investigate the incidence of COVID-19 in patients undergoing primary percutaneous coronary intervention (PCI) for myocardial infarction and identify associated demographic and clinical characteristics.

Methods:
In this study, a retrospective and descriptive cross-sectional design was used to examine all patients (a total of 85) who experienced acute myocardial infarction and underwent primary percutaneous coronary intervention (PCI). The study measured various parameters, such as
COVID-19 status, age, sex, ethnicity, diabetes, and hypertension. Data analysis was conducted
using SPSS version 25 software.

Results:
Out of the 85 patients who underwent primary percutaneous coronary intervention
(PCI) for myocardial infarction (MI), 14 patients (16.5%) were found to have COVID-19.
COVID-19 diagnosis was confirmed through RT-PCR testing for 2 patients, while the remaining
12 patients were diagnosed using lung CT scans. Among the COVID-19 patients, 21.4% (n = 3)
had background diabetes, and 7.1% (n = 1) had background hypertension. MI recurrence was
observed in 14.3% of COVID-19 patients (2 cases). Unfortunately, 1 COVID-19 patient, a 70-
year-old Persian woman with diabetes and hypertension, passed away. No significant differences
were found in terms of age, sex, ethnicity, underlying diabetes, or underlying hypertension between the COVID-19 and non-COVID-19 groups.

Conclusion:
The high occurrence of COVID-19 among myocardial infarction (MI) patients undergoing primary percutaneous coronary intervention (PCI) is worth noting. Further investigation is recommended to explore the impact of demographic and contextual factors on the severity
and outcomes of primary PCI in MI patients with COVID-19, as well as the underlying mechanisms involved.
Mitochondrial Inherited Disorders and their Correlation with Neurodegenerative Diseases
Authors: Gushi Sofjana , Balis Vasileios 
Published: November 2023

Abstract::Mitochondria are essential organelles for the survival of a cell because they produce energy. The cells that need more mitochondria are neurons because they perform a variety of tasks that are necessary to support brain homeostasis. The build-up of abnormal proteins in neurons, as well as their interactions with mitochondrial proteins, or MAM proteins, cause serious health issues. As a result, mitochondrial functions, such as mitophagy, are impaired, resulting in the disorders described in this review. They are also due to mtDNA mutations, which alter the heritability of diseases. The topic of disease prevention, as well as the diagnosis, requires further explanation and exploration. Finally, there are treatments that are quite promising, but more detailed research is needed.
Applications of Nanomedicine in Brain Tumor Therapy: Nanocarrierbased Drug Delivery Platforms, Challenges, and Perspectives
Authors: Verma Ravinder , Rao Lakshita , Kumar Harish , Bansal Nitin , Deep Aakash , Parashar Jatin , Yadav Manish , Mittal Vineet , Kaushik Deepak 
Published: November 2023

Background:
The most difficult kind of cancer to treat is brain cancer, which causes around
3% of all cancer-related deaths. The targeted delivery is improved with the use of technologies based
on nanotechnology that are both safe and efficient. Because of this, there is now a lot of research being
done on brain cancer treatments based on nanoformulations.

Objective:
In this review, the author's primary aim is to elucidate the various nanomedicine for brain
cancer therapy. The authors focus primarily on the advancement of nanotechnology in treating brain
cancer (BC). This review article gives readers an up-to-date look at publications on sophisticated
nanosystems in treating BC, including quantum dots (QDs), nanoparticles (NPs), polymeric micelles
(PMs), dendrimers, and solid lipid nanoparticles (SLNs), among others. This article offers insight into
the use of various nanotechnology-based systems for therapy as well as their potential in the future.
This article also emphasizes the drawbacks of nanotechnology-based methods. Future perspectives
for treating brain cancer using proteomics and biomimetic nanosystems are briefly discussed.

Conclusion:
In this review, we review several aspects of brain cancer therapy, including various nanomedicines,
their challenges and future perspectives. Overall, this article gives a thorough overview
of both the present state of brain cancer treatment options and the disease itself.
An Efficient Suppression of EGFR and B-Raf mRNA Overexpression in the Lung of Benzo[a]pyrene-induced mice by Cationic Lipo-ATRA Nanoformulation
Authors: Mariammal Berlin Grace Viswanathan , Wilson Devarajan David , Siddikuzzaman  , Singaram Viswanathan , Ravichandran Ragavi , Chandrasekharan Guruvayoorappan , Chinnadurai Kathirvelan 
Published: November 2023

Background:
The molecular drug all-trans retinoic acid (ATRA) acts on cancer cells via
different molecular pathways, but its poor bioavailability in cancer cells limits its potency. This study
was, therefore, carried out to analyse the oncogene expressions in the lung tissue of benzo[a]pyrene
(B[a]P)-induced mice and compare between free ATRA and cationic liposome nanoformulation (lipo-
ATRA) treatments.

Objective:
This study was designed to analyse the changes in the expression levels of epidermal
growth factor receptor (EGFR) and B-Raf in the lung tissues of B[a]P-induced mice during the cancer
development stage itself and to find the suppressive effect of free ATRA and lipo-ATRA.

Methods:
Lung cancer was induced in mice by oral ingestion of 50mg/kg body weight B[a]P weekly
twice for four consecutive weeks. Then, the mice were treated with free and lipo-ATRA (0.60mg/kg)
for 30 days via i.v injection. The EGFR and B-Raf gene expressions were analyzed in lung cells by
reverse transcriptase polymerase chain reaction (RT-PCR) and quantitative polymerase chain reaction
(qPCR).

Results:
The RT-PCR gene band density and the relative quantity (RQ) values from qPCR revealed
both EGFR and B-Raf genes to be significantly overexpressed in B[a]P control mice while having very
low or no expression in normal mice. This indicates that they function as oncogenes in B[a]P-induced
lung carcinogenesis. The lipo-ATRA treatment has shown a highly significant increase in RQ values
for both EGFR and BRaf when compared to the free ATRA treatment.

Conclusion:
The study results have revealed the cationic lipo-ATRA treatment to have enhanced the
bioavailability of ATRA in lung tissue due to its significant suppression action on EGFR-mediated
oncogenes’ expressions. Furthermore, the EGFR and BRaf could be the molecular targets of ATRA
action in lung carcinogenesis.
Phthalate-induced Toxicity and its Mitigation by Natural Plant Products
Authors: Gaur Kajal , Siddique Yasir Hasan 
Published: November 2023

Abstract:
Phthalates are common synthetic chemicals in various industrial and consumer products,
including plastics, personal care products, and medical equipment. They are dangerous
even at extremely low concentrations during the crucial stages of life, such as pregnancy, infancy,
early childhood, and adolescence. In recent years, there has been increased interest in looking
into natural plant components as potential phthalate toxicity mitigators. Phthalates have been
related to a number of health problems, including endocrine disruption, reproductive and developmental
disorders, and carcinogenicity. As a result, effective ways to decrease phthalate exposure
and attenuate its negative effects are required. Natural plant products have shown the potential
to reduce phthalate toxicity via various methods. These methods include antioxidant and anti-
inflammatory properties, detoxifying enzyme regulation, and competition for phthalate binding
sites. Certain plant-derived chemicals, such as polyphenols, flavonoids, terpenes, and alkaloids,
have been shown to interact with phthalates and potentially limit their absorption, distribution,
and metabolism inside the body. This review highlights the effects of several naturally occurring
plant products, such as apigenin, taxifolin, vitamin C, and many more, on the toxicity of
phthalates. Natural products use nowadays is increasing due to their non-toxic nature, so in the
future, more focus should be in favor of increasing the use of these natural products that we obtained
from plants.
Augmented Reality Control based Energy Management System for Residence
Authors: Kandasamy Prabaakaran , Veeramani Thilagar Kannappan , Munusamy Venkatesh , Sanjth Sudharsan , Amurthavalli Sethuraman , Balaji Barath Chander 
Published: November 2023

Introduction:
The roots of virtual reality (VR) go back to the work of Ivan Sutherland
in the 1960s. At the time, virtual reality showed promise in universities and labs, peaking in the
early 1990s at a stable level. The latest form of IoT is merging with the Internet of Everything
(IOE). Using this technology, users can access any device, device, and machine in the environment
through any middleware application or system. In recent years, smart speakers have become
a common commercial method for controlling household appliances, solving some of the
problems of remote control. For example, speech recognition is difficult in noisy environments
and is minimized using noise cancellation. It also takes a long time to determine the current state
of the device as the user need to request or issue a command to the smart speaker and need to
wait for a response. The evaluation of prototype system found, using a device with gestures and
interacting with a virtual 3D device instead of a real device was acceptable in terms of usability.
In this article, the Unity and Vuforia are used to create an AR-based IoT virtual switch that can
control any device connected to a LAN controller via HTTP requests.

Methods:
The system is made experimental with the Augmented Reality (AR), the virtual communication
system is designed instead of physical mode. It provide the real time based image for
active control of Energy management. It consist of virtual switches, it supports the AR based
power control system.

Results:
The proposed system are made evaluated and tested under various load conditions. The
virtual image consist of virtual switches to make real time control of power equipment. The proposed
system achieve the latency of about 0.06 sec.

Conclusion:
The advancement in day today activities required with AR based energy management
system with proper control measures. The designed system is supportive for such mechanism.
The further system is proposed to make more energy saving concept for enhancement in
proposed work.
Cohabitation Study of Tricolour Langur (Presbytis chrysomelas ssp. cruciger) and Proboscis Monkey (Nasalis larvatus) in Bukit Semujan Danau Sentarum National Park
Authors: Santoso Nyoto , Diva Alfatheya Margwita , Fauziah Natasya Nurul , Sutopo Sutopo 
Published: November 2023

The tricolour langur and proboscis monkey in Bukit Semujan cohabited and utilized the same resources. Cohabitation, mainly due to resource constraints, needed substantial attention to ensure the survival of these primates. This research aimed to map the utilization of canopy strata vertical forest structure and vegetation as food sources and identify the size and overlap of ecological niches for both primates. This research occurred in Danau Sentarurn National Park (DSNP) from July to December 2021. The data collection employed the ad libitum method. The results indicated that cohabitation occurred in the canopy strata vertical forest structure utilization, particularly stratum B and C, and was related to food availability for both primates. The Jaccard Index of the stratum utilization association was 0.6 for swamp forests and 0.8 for hillside forests, while the food plant association was 0.2. In addition, the ecological niche of the tricolour langur overlapped 48% against the proboscis monkey and 34% on the contrary. The tricolour langur's niche size (FT) was 0.32278 ≤ 0.5960 ≥ 0.81253, while the proboscis monkey was 0.20866 ≤ 0.52837 ≥ 0.78529 at 95% confidence interval.
Effect of Nano-Fertilizers on Growth and Yield of Summer Hybrid Maize (Zea mays L.) in Gangetic Plains of India
Authors: Roy Deblina , Sengupta Kajal , Mondal Ramyajit , Gunri Sunil Kumar , Ali Osman , Madhu H. S. 
Published: November 2023

Nano fertilizer contains the nutrients in a concentrated and energy farm which would also pave the way to have a successful harvest without soil application and to reduce the ill effect on soil. In this regard, the present experiment was carried out over two years at BCKV, West Bengal, India in the Gangetic alluvial soil, to assess the impact of nano fertilizer management on growth and yield of summer hybrid maize cv. ‘Kaveri 50’. The treatments comprised different percentage of recommended dose of fertilizer (RDF) with or without nano fertilizer application. Results revealed that application of 50 % RDZn and 100 % N-P-K along with 2 foliar sprays of Nano-Zn @ 4 ml litre-1 at 25 and 50 DAS (T8) recorded better results of growth attributes. The yield attributes like number of cobs plant-1 (1.30), cob length (21.30 cm), cob girth (16.25 cm), number of rows cob-1 (13.97), number of grains cob-1 (317.6), seed index (25.40 g) and single cob weight (128.74 g) also found highest from the same treatment. Higher grain (8.16 t ha-1) and stover yield (12.22 t ha-1) were recorded in T8 treatment and yield variation was 2.21 to 63.86 % over control with highest benefit-cost ratio (2.35). Hence, application of 50 % RDZn and 100 % N-P-K along with 2 foliar sprays of Nano-Zn @ 4 ml litre-1 at 25 and 50 DAS could be more effective in augmenting yield, available nutrient status and economics of summer maize in the Gangetic plains of India.
ЦІНА ТА ЦІНОУТВОРЕННЯ В ЛОГІСТИЦІ
Authors: Ерфан В.Й. , Сингаєвський С.С. , Мухомедьянов В.А. 
Published: November 2023

Логістика, як ключовий елемент сучасного бізнесу, стала невід’ємною частиною ефективної діяльностіпідприємств. Однак, вирішальне значення має здатність раціонально управляти не лише логістичнимипроцесами, але й ціноутворенням. Правильна стратегія ціноутворення може стати ключовимфактором для досягнення успіху, прибутковості та забезпечення конкурентоспроможності.Ціноутворення, як важливий аспект стратегії підприємства, вимагає комплексного підходу та аналізу.У цій статті автори докладніше розглядають взаємозв’язки між логістикою та ціноутворенням,визначають ключові фактори, що впливають на формування ціни. А також розглядають різні стратегіїціноутворення, які можуть бути застосовані в логістичній галузі. Також, аналізують, як логістикаможе допомогти оптимізувати цінову політику та досягти стратегічних цілей підприємства.
Ключові слова: ціна, ціноутворення, логістична система, витрати, конкурентоспроможність.
АНАЛІЗ ВПЛИВУ ПРОЦЕСУ ДЕЦЕНТРАЛІЗАЦІЇ НА БЮДЖЕТНИЙ ПОТЕНЦІАЛ ТЕРИТОРІАЛЬНИХ ГРОМАД
Authors: Варцаба В.І. , Сембер С.В. , Траньович Ю.П. 
Published: November 2023

У статті проведено аналіз змін у формуванні місцевих бюджетів, обумовлених децентралізаційноюреформою. Окреслено законодавчі зміни, які впливали на формування бюджетів органів місцевогосамоврядування з початку децентралізаційної реформи та внаслідок воєнного стану. Проведено оцінкувпливу реформи на бюджетні показники територіальних громад Закарпатської області за 2020-2022роки. Охарактеризовано наслідки повномасштабної війни для місцевих бюджетів у 2021-2023 роках таописано ризики, які можуть очікувати територіальні громади у 2024 році.
Ключові слова: бюджети територіальних громад, децентралізаційна реформа, доходи, податковінадходження, воєнний стан.
КОНЦЕПТУАЛЬНІ ПІДХОДИ ПОЛІТИКИ І МЕХАНІЗМІВ ПРИРОДОКОРИСТУВАННЯ
Authors: Лабенко О.М. 
Published: November 2023

Нині людство знаходиться на такому етапі, коли існуюча екологічна політика вимагає кардинальноїтрансформації, орієнтуючись на цілі сталого розвитку. Метою статті є визначення підходів аналізуполітики природокористування та механізмів його регулювання. Важливою передумовою ефективноїоцінки даної політики є визначення її концептуальних підходів, які невід’ємно пов’язані із ризиками, щовипливають з таких дій. Виокремлюють економічний, правовий та адміністративний механізмирегулювання природокористування, аналіз яких показує, що нині вони недостатньо результативні. Томузабезпечити раціональне природокористування в Україні можливо за рахунок створення концепціїкомплексного природокористування.
: регулювання природокористування, концептуальні підходи, механізми регулюванняприродокористування, раціональне природокористування.
ПОДАТКОВІ ІМПЕРАТИВИ ФОРМУВАННЯ ДОХОДІВ МІСЦЕВИХ БЮДЖЕТІВ УКРАЇНИ ТА ЇХ ВПЛИВ НА РОЗВИТОК РЕГІОНІВ
Authors: Фурик І.І. 
Published: November 2023

У статті досліджено питання щодо податкової політики та податкових імперативів формуваннядохідної частини місцевих бюджетів України, в тому числі в умовах воєнного стану. Досліджено основніпідходи до тлумачення поняття «податкові імперативи місцевих бюджетів». Виділено ключові аспектиподаткових імперативів, що впливають на формування дохідної частини бюджетів на місцях. Здійсненоаналіз складу доходів місцевих бюджетів України, їх структуру та динаміку за період 2014 – 2022рр.Проведено аналіз динаміки податкових надходжень в розрізі податку на доходи фізичних осіб, єдиногоподатку, акцизного та земельного податків, податку на прибуток підприємств, плати за адміністративніпослуги. Досліджено та проаналізовано умови справляння даних видів податків в умовах внесених доподаткового законодавства змін під впливом воєнного стану. Визначено основні позитивні та негативніфактори впливу податкових імперативів на розвиток регіонів.
Ключові слова: місцеві бюджети, податкова політика, податкові імперативи, доходи, структура доходівмісцевих бюджетів, власні доходи, податкові надходження, неподаткові надходження, міжбюджетнітрансферти, війна, воєнний стан.
БІЗНЕС-РИЗИК В СИСТЕМІ УПРАВЛІННЯ АКТИВАМИ: АНАЛІЗ, ОЦІНКА І ПРИЙНЯТТЯ РІШЕНЬ
Authors: Йолтуховська О.Ю. , Шеверя Я.В. , Ганусич В.О. 
Published: November 2023

Ефективне та стійке управління діяльністю комерційного підприємства залежить від досвіду тамайстерності прийняття рішень, які дають змогу на належному рівні забезпечити високу ліквідність,рентабельність, ділову активність та надійний захист від негативного впливу підприємницьких ризиків, щовимагає розробки адекватних методів обліку, оцінки, аналізу та управління активами підприємства. Длянаукового вирішення цієї проблеми необхідно провести дослідження проблематики обліково-аналітичногозабезпечення системи управління, аналітичного обґрунтування та оцінки активів у системі управління нимита розробки пропозицій з удосконалення облікової та аналітичної складової системи управління активами вмежах ефективного управління бізнес-ризиками.
Ключові слова: бізнес-ризик, облікова політика, оцінка, активи, обліково-аналітичне забезпечення управління,система управління активами.
ВДОСКОНАЛЕННЯ СИСТЕМИ УПРАВЛІННЯ ПЕРСОНАЛОМ У СФЕРІ АГРАРНОГО РОЗВИТКУ
Authors: Газуда С.М. , Герцег В.А. , Оприсок М.Д. 
Published: November 2023

У статті розглянуто особливості удосконалення системи управління персоналом у сфері аграрногорозвитку. Проаналізовано стан трудових ресурсів аграрної сфери, зазначено функціональність системиуправління персоналом, виявлено основні проблеми та сучасні тенденції розвитку організації аграрногоменеджменту. Виокремлено рекомендації щодо вдосконалення системи управління персоналом аграрноїсфери, зі спрямуванням на підвищення ефективності, продуктивності праці персоналу та соціально-економічне зростання галузі.
Ключові слова: система управління персоналом, сфера аграрного розвитку, трудові ресурси, мотивація,аграрний менеджмент, конкурентне середовище, функціональність, аграрне господарювання.