bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of CGF combined with GBR in alveolar bone increment for patients with anxiety disorder: A rare case report and literature review
Authors: Li Zhixin , Yang Chao , Wang Jinrong , Zheng Kaiyue , Luo Wen 
Published: November 2023

Rationale:
Selective serotonin reuptake inhibitors (SSRIs), one of the commonly used anti-anxiety drugs, may have impacts on bone metabolism and potentially lead to drug-induced osteoporosis. The traditional approach of oral implantation in individuals with both anxiety disorder and drug-induced osteoporosis poses a significant challenge. To address this issue, concentrated growth factor (CGF) has been utilized in patients undergoing concurrent alveolar ridge augmentation during oral implantation, resulting in favorable clinical outcomes. Consequently, combining CGF with guided bone regeneration (GBR) in alveolar bone increment may represent a promising new surgical approach for such patients. In this report, we present a case study of a 25-year-old male with anxiety disorder and drug-induced osteoporosis, in who CGF combined with GBR was employed in alveolar bone increment.

Patient concerns:
This article reports the case of a 25-year-old male who underwent cone beam computed tomography (CBCT) due to the absence of his right lower second molar for a period of six months. The CBCT scan revealed significant bone defects, which were attributed to the tooth loss and prolonged use of anti-anxiety drugs. Consequently, the patient sought medical assistance from our department.

Diagnoses:
Based on the patient's self-report, he was diagnosed with an anxiety disorder. Additionally, the CBCT scan confirmed the loss of the right mandibular second molar and revealed the presence of dental irregularity and an alveolar bone defect.

Interventions:
During the patient's course of treatment with anti-anxiety medication, a combination of CGF and GBR was employed for the simultaneous implantation of the missing right mandibular second molar, along with bone augmentation.

Outcomes:
The patient had a follow-up visit two weeks after the surgical procedure, and the wound in the operation area had healed satisfactorily. Six months later, CBCT images revealed excellent osseointegration. The buccal and lingual width of the alveolar bone measured 6.95mm, which was an increase of 1.35mm compared to the pre-implantation stage.

Lessons:
This article presents a case study in which CGF combined with GBR were utilized to address alveolar bone augmentation during the implantation phase in patients taking anti-anxiety medication. The results demonstrated that CGF combined with GBR, as a cutting-edge platelet concentrate technique, could effectively stimulate bone tissue proliferation in individuals who have been on long-term anti-anxiety medication, specifically in oral implant areas. This approach can help prevent poor osseointegration, promote higher osseointegration rates, and facilitate wound healing.
Effects of technology-assisted rehabilitation for patients with hip arthroplasty: A meta-analysis
Authors: Wu Lingyun , Li Xiaoyan , Hua Lijiangshan , Sun Qiuhua 
Published: November 2023

Background:
To investigate the efficacy of technology-assisted rehabilitation compared to that of usual care programs after total hip arthroplasty (THA) through randomized controlled trials (RCTs).

Methods:
The Medline (PubMed), Cochrane Library, Embase and Web of Science databases were searched for RCTs regarding the efficacy of technology-assisted rehabilitation following THA. Data were analyzed using Stata 12.0 software.

Results:
Eleven RCTs involving 1327 patients were included in the meta-analysis. The pooled effect size showed that compared to usual care, telerehabilitation significantly improved the Harris score (standardized mean difference [SMD] 0.74, 95% confidence interval [CI] 0.58 to 0.90) and functional independence measure (FIM) score (SMD 1.26, 95% CI 0.48 to 2.03). In addition, video-based therapy could significantly improve walk test results (SMD 0.43, 95% CI 0.11 to 0.75).

Conclusion:
The findings suggest that technology-assisted rehabilitation, especially telerehabilitation, have been shown to improve the physical function of patients following THA compared to conventional rehabilitation. More robust studies are needed to validate the long-term efficacy and safety of innovative technology-assisted training strategies.
Effect of eardrum perforation and chronic otitis media on the results of infrared tympanic thermometer in adults: A systematic review and meta-analysis
Authors: Kim Yee-Hyuk , Park Hee-Jun , Yoo Jae-Ho 
Published: November 2023

Background:
This study was conducted to determine whether tympanic membrane perforation or chronic otitis media affects the results of an infrared tympanic membrane thermometer in adults.

Methods:
A literature search was performed using PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar.

Results:
Four nonrandomized studies were included in the analysis. The temperatures of the bilateral eardrums (one eardrum with normal condition [control group] and the other eardrum with perforation or chronic otitis media [experimental group]) were measured for the same subject in the studies. The mean and standard deviation of the bilateral tympanic membrane temperatures were used to calculate the mean difference (MD) with a corresponding 95% confidence interval (CI). The fixed-effect model was utilized based on the results of the heterogeneity measurement using the Chi2 test and I
2 statistic. The results of a meta-analysis in the normal eardrum (control group) and perforated eardrum, chronic suppurative otitis media with tympanic membrane perforation, or chronic otitis media with cholesteatoma (experimental group) were 343 subjects (MD = 0.05; 95% CI = −0.00 to 0.11; P = .06). A meta-analysis of the normal eardrum (control group) and perforated eardrum or chronic suppurative otitis media with tympanic membrane perforation except for cholesteatoma (experimental group) found 296 subjects (MD = 0.05; 95% CI = −0.01 to 0.11; P = .10).

Conclusion:
When the temperatures of the bilateral eardrums were measured using an infrared tympanic membrane thermometer, no difference was observed between the eardrum with perforation or chronic otitis media and the normal eardrum.
Minocycline in depression not responding to first-line therapy: A systematic review and meta-analysis
Authors: Shamim Muhammad Aaqib , Manna Subhanwita , Dwivedi Pradeep , Swami Mukesh Kumar , Sahoo Swapnajeet , Shukla Ravindra , Srivastav Shival , Thaper Kashish , Saravanan Aswini , Anil Abhishek , Varthya Shoban Babu , Singh Surjit , Shamim Muhammad Aasim , Satapathy Prakisini , Chattu Soosanna Kumary , Chattu Vijay Kumar , Padhi Bijaya K. , Sah Ranjit 
Published: November 2023

Background:
Major depressive disorder is often resistant to first-line treatment, with around 30% failing to respond to traditional therapy. Treatment-resistant depression results in prolonged hospitalization and healthcare costs. Anti-inflammatory drugs have shown promising results in depression not responding to initial therapy. Minocycline has anti-inflammatory properties and crosses the blood-brain barrier. It has demonstrated varied results in several randomized controlled trials (RCTs).

Methods:
We assessed the efficacy of minocycline compared to placebo in depression not responding to one first-line antidepressant via a systematic review and meta-analysis. We performed a comprehensive literature search across PubMed, Cochrane, and Scopus for RCTs. We visualized the results using forest plots and drapery plots. We assessed and explored heterogeneity using I
2, prediction interval, and meta-regression. Then, we rated the certainty of the evidence.

Results:
Four RCTs revealed a non-significant difference in depression severity [−3.93; 95% CI: −16.14 to 8.28], rate of response [1.15; 0.33–4.01], and rate of remission [0.94; 0.44–2.01]. However, the reduction in depression severity is significant at a trend of P < .1. The high between-study heterogeneity (I
2 = 78%) for depression severity could be answered by meta-regression (P = .02) for the duration of therapy.

Conclusion:
There is no significant difference with minocycline compared to placebo for depression not responding to first-line antidepressant therapy. However, the treatment response varies with treatment duration and patients’ neuroinflammatory state. Thus, larger and longer RCTs, especially in diverse disease subgroups, are needed for further insight. This is needed to allow greater precision medicine in depression and avoid elevated healthcare expenditure associated with hit-and-trial regimens.

Registration:
CRD42023398476 (PROSPERO).
FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures overlaying anti-N-methyl-D-aspartate receptor encephalitis: A case report
Authors: Fu Qingxi , Wang Guangying , Che Fengyuan , Li Dong , Wang Shougang 
Published: November 2023

Rationale:
FLAIR-hyperintense lesions in anti-myelin oligodendrocyte glycoprotein (MOG)-associated encephalitis with seizures (FLAMES) is a rare clinical phenotype of anti-MOG; immunoglobulin G-associated disease is often misdiagnosed as viral encephalitis in the early stages. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune encephalitis caused by antibodies targeting the GluN1 subunit of the NMDAR. The coexistence of anti-NMDAR encephalitis and FLAMES is very rare.

Patient concerns:
A 20-year-old female patient initially presented with seizures accompanied by daytime sleepiness.

Diagnoses:
Magnetic resonance imaging revealed FLAIR-hyperintense lesions in unilateral cerebral cortex. NMDAR antibodies was positive in the cerebrospinal fluid and MOG antibodies in the serum.

Interventions:
Steroid therapy was administrated.

Outcomes:
The symptoms completely relieved. At 6-month follow-up, the patient’s condition remained stable. Magnetic resonance imaging showed no abnormalities in the unilateral cerebral cortex.

Conclusion:
When a patient with anti-NMDAR encephalitis or FLAMES is encountered in clinical practice, the coexistence of these diseases with double-positive anti-NMDAR and MOG antibodies should be considered and adopt appropriate evaluation and treatment.
Uterine torsion with degeneration and infarction of giant leiomyoma in a postmenopausal woman: A case report
Authors: Ye Zhongxue , Jiang Yafen , Yan Kun , Yu Chen 
Published: November 2023

Rationale:
Uterine torsion and giant leiomyoma are both rare diseases. Uterine torsion combined with giant leiomyoma with degeneration or infarction is easy to be misdiagnosed. We wrote this case to increase the accuracy and timeliness of medical staff’s diagnosis and treatment of uterine fibroids combined with uterine torsion.

Patient concerns:
We present a case of uterine torsion with degeneration and infarction of giant leiomyoma in a 66-year-old postmenopausal woman, who had a lump in her pelvis 10 years ago and suffered from acute abdominal pain half a day before hospitalization.

Diagnosis:
The patient was considered as uterine torsion with huge abdominal mass by computed tomography and enhanced magnetic resonance imaging, and finally diagnosed as uterine torsion with giant leiomyoma through surgery and pathological examination.

Interventions and outcomes:
The patient underwent exploratory laparotomy. In addition to the removal of huge uterine fibroids, the hysterectomy with double appendages was conducted. The histopathologic analysis showed “(Uterine tumor) leiomyoma with extensive edema, degeneration, infarction and calcification.” The patient recovered well after operation and kept healthy in the follow-up to date.

Lessons:
Although uterine torsion is extremely rare, early diagnosis and treatment are essential to prevent serious complications.
A case report of acute myocardial infarction with extremely severe thrombocytopenia after percutaneous coronary intervention
Authors: Chen Shuai , Wang Hongqi , Ning Bin 
Published: November 2023

Introduction:
The case report’s purpose is to remind doctors a rare complication named thrombocytopenia of antithrombotic drugs. As a result, severe bleeding or even life-threatening situations may be avoided.

Patient concerns:
A specific case of a patient with acute myocardial infarction, a significant decrease in platelet count was observed after percutaneous coronary intervention.

Diagnosis:
After ruling out other potential causes, the medical team considered tirofiban-induced thrombocytopenia as a possible explanation.

Interventions and outcomes:
Through careful monitoring and adjustment of medication, the patient’s platelet count eventually returned to normal.

Conclusion:
To ensure patient safety, it is advised to regularly monitor platelet counts at intervals of 2 to 6 hours before and after administering tirofiban.
Case report: Severe cholestatic jaundice associated with hyperthyroidism treated with methimazole
Authors: Liu Xiaoqiang , Xu Boming , Zeng Yilin , Chen Peizhong , Wang Yubin 
Published: November 2023

Rationale:
We present a case of a 43-year-old female patient diagnosed with hyperthyroidism. This study aims to demonstrate the rare association between hyperthyroidism and severe cholestatic jaundice, and the effectiveness of methimazole treatment.

Patient concerns:
The patient developed severe jaundice, a typically mild symptom in most hyperthyroidism cases.

Diagnosis:
The severe jaundice was suspected to be a result of cholestasis induced by hyperthyroidism, with other potential causes such as drug-induced or autoimmune liver dysfunction being ruled out.

Outcomes:
The patient was effectively treated with methimazole. Outcomes: Treatment with methimazole alleviated the severe cholestatic jaundice and restored normal thyroid function.

Lessons:
The specific mechanism of cholestasis as a secondary complication of hyperthyroidism remains unclear, and there are no specific biochemical markers for cholestasis caused by this hormonal disease. This case underscores the possibility of severe jaundice as a clinical manifestation of hyperthyroidism, and highlights antithyroid drug treatment as an effective strategy for managing severe cholestatic jaundice.
A CARE-compliant article: A case report of unusual eschar and extensive soft tissue necrosis in Tsutsugamushi disease
Authors: Byeon Je Yeon , Kim Hyun , Lee Da Woon , Choi Hwan Jun 
Published: November 2023

Rationale:
Tsutsugamushi disease is a common infectious disease in the Northern Hemisphere. A patient infected with tsutsugamushi disease will show a characteristic clinical course with eschar formation, which is mostly small and self-limited in nature without causing major problems. We report a rare case of unusually extensive necrosis started from a small eschar.

Patient concerns:
In this report, a 65-year-old female patient with a history of diabetes mellitus present an 8 × 6 cm-sized huge eschar and extensive soft tissue necrosis aggravated from a small eschar. Also, there were 3 other small eschars in the scalp and left flank area. In early July, she was farming in a field in Hongseong-gun, South Korea. She had been treated at another hospital for 2 weeks. However, the eschar became bigger and worse.

Diagnoses:
After admission, escharectomy was performed and extensive soft tissue necrosis was identified. Orientia tsutsugamushi antibody tests were positive from blood test. Providencia rettgeri and Enterococcus faecalis were detected in a tissue bacterial culture test.

Intervention:
While using oral azithromycin and intravenous imipenem/cilastatin, the necrosis of the thigh was excised and covered by lateral femoral circumflex artery based myocutaneous Keystone flap.

Outcomes:
The remaining small eschars recovered spontaneously, the large eschars that had caused necrosis were successfully treated, and all other clinical symptoms improved without complications.

Lessons:
For unusual eschar of an unknown cause, especially in patients with uncontrolled diabetes or immunocompromised, the possibility of Tsutsugamushi should be considered. Careful physical examination and proper management should be performed as soon as possible.
Sensorineural hearing loss induced by gefitinib: A CARE-compliant case report and literature reviews
Authors: Zhu Bao-chen , Yang Wen-hua , Huang Mao , Wang Jin-gui , Liang Yan , Lei Zhen-zhen , Zhang Sha-sha , Wang Ying , Sun Xiao-di , Gong Ying , Xue Chun-miao , Hua Guo-dong 
Published: November 2023

Rationale:
Gefitinib is a potent and selective orally active growth factor receptor (EGFR)-tyrosine kinase inhibitor that is commonly used to treat advanced non-small cell lung cancer patients with activating EGFR mutations. Hearing impairment with gefitinib was sparsely reported. In this report, we describe a case of sensorineural deafness associated with the administration of gefitinib, with a Naranjo score of 7.

Patient concerns:
An 81-year-old female was diagnosed with lung adenocarcinoma with bone metastasis and an EGFR-activating mutation. The patient was prescribed gefitinib tablets at a daily dose of 250 mg for lung adenocarcinoma treatment. However, the patient experienced moderate to severe bilateral sensorineural deafness, primarily in her right ear, after taking gefitinib. Following the cessation of gefitinib administration, the patient exhibited partial restoration of auditory function. Upon resuming the medication, she experienced a worsening of deafness.

Diagnoses:
The otoscopic audiogram and hearing test indicated moderate to severe bilateral sensorineural deafness.

Interventions:
The otolaryngologist recommended bilateral hearing aids to enhance hearing function.

Outcomes:
Throughout our follow-up period, the patient did not receive a hearing aid implant.

Lessons:
This article first reported the ototoxicity caused by gefitinib. While rare, our report highlights that gefitinib-induced sensorineural deafness is possible and its mechanisms are still unclear. This adverse reaction should be monitored closely during clinical application of gefitinib to improve patient outcomes.
A Prognostic Model for Critically Ill Children in Locations With Emerging Critical Care Capacity*
Authors: Chandna Arjun , Keang Suy , Vorlark Meas , Sambou Bran , Chhingsrean Chhay , Sina Heav , Vichet Pav , Patel Kaajal , Habsreng Eang , Riedel Arthur , Mwandigha Lazaro , Koshiaris Constantinos , Perera-Salazar Rafael , Turner Paul , Chanpheaktra Ngoun , Turner Claudia 
Published: November 2023

OBJECTIVES:
To develop a clinical prediction model to risk stratify children admitted to PICUs in locations with limited resources, and compare performance of the model to nine existing pediatric severity scores.

DESIGN:
Retrospective, single-center, cohort study.

SETTING:
PICU of a pediatric hospital in Siem Reap, northern Cambodia.

PATIENTS:
Children between 28 days and 16 years old admitted nonelectively to the PICU.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Clinical and laboratory data recorded at the time of PICU admission were collected. The primary outcome was death during PICU admission. One thousand five hundred fifty consecutive nonelective PICU admissions were included, of which 97 died (6.3%). Most existing severity scores achieved comparable discrimination (area under the receiver operating characteristic curves [AUCs], 0.71–0.76) but only three scores demonstrated moderate diagnostic utility for triaging admissions into high- and low-risk groups (positive likelihood ratios [PLRs], 2.65–2.97 and negative likelihood ratios [NLRs], 0.40–0.46). The newly derived model outperformed all existing severity scores (AUC, 0.84; 95% CI, 0.80–0.88; p < 0.001). Using one particular threshold, the model classified 13.0% of admissions as high risk, among which probability of mortality was almost ten-fold greater than admissions triaged as low-risk (PLR, 5.75; 95% CI, 4.57–7.23 and NLR, 0.47; 95% CI, 0.37–0.59). Decision curve analyses indicated that the model would be superior to all existing severity scores and could provide utility across the range of clinically plausible decision thresholds.

CONCLUSIONS:
Existing pediatric severity scores have limited potential as risk stratification tools in resource-constrained PICUs. If validated, our prediction model would be a readily implementable mechanism to support triage of critically ill children at admission to PICU and could provide value across a variety of contexts where resource prioritization is important.
Epidemiological Profile of Victim Patients of Facial Canine and Human Bites in a Public Hospital
Authors: Rocha João Lucas Farias do Nascimento , Leão Cássio Cesar Arrais , Canedo Lucas Ribeiro , Macedo Luis Felipe Rosa de , Rosa Simone Corrêa , Macedo Jefferson Lessa Soares de 
Published: November 2023

Introduction:
Bites are among the most common types of trauma to which humans are exposed. The possibility of disfiguring lesions and the transmission of infectious diseases with high morbidity make this trauma a public health problem.

Method:
This was a retrospective, descriptive study that analyzed the medical records of patients treated at the Emergency Unit of the Plastic Surgery Service of the Asa Norte Regional Hospital from March 2019 to March 2020. The variables analyzed included age, sex, origin, time interval from aggression to hospital care, aggressor agent, wound site, lesion characteristics, and treatment.

Results:
A total of 103 patients with a mean age of 25 years were evaluated. Most patients were male (57.3%), and 73.8% were from the Federal District. The most common type of treatment was direct suturing in 77.7% of cases, followed by local flaps (15.5%) or grafts (4.9%). There were no deaths or infections reported.

Conclusion:
The predominant profile of a facial bite victim is a young male adult living in the Federal District, bitten by a canine and treated with direct sutures. Adequate treatment for animal bites should include prevention of infection, such as rabies and tetanus, as well as primary wound closure for achieving a better prognosis and satisfactory esthetics for the patient.