bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrés y ansiedad en estudiantes de enfermería durante la primera ola de la pandemia de COVID-19
Authors: Robledo Martín Juana , Acea López Lorena , Alcolea Cosín María Teresa , Pérez Urdiales Iratxe , Bellon Filip , Oter Quintana Cristina , Blanco Blanco Joan , Rubinat Arnaldo Esther , Pastor Bravo María del Mar , Briones Vozmediano Erica 
Published: January 2024

Objective: To compare anxiety and acute stress levels among nursing students who joined the labour market during the first wave of the COVID-19 pandemic and those who did not.
Methods: A cross-sectional, multicentre descriptive study across three Spanish public universities. A total of 216 nursing students participated in our study. Data collection was carried through an online questionnaire, that included variables on conditions for entering the labour market, the Zung Anxiety Self-Assessment Scale and the Stanford Acute Stress Reaction Questionnaire. We performed univariate and multivariate analyses.
Results: Overall, 42.6% (n=92) of the students entered the labour market during the first wave of the COVID-19 pandemic. The global anxiety score was x?=36.31 (SD=5.71) and the stress score was x?=82.39 (SD=30.84). Lower anxiety levels were observed among those who joined the labour market (x?=35.67; SD=5.78) as compared to those who did not (x?=36.73; SD=5.67). Overall 92.4% of the students were acutely stressed. Acute stress was higher among those who did not work (x?=84.35; SD=32.38) and significantly in women.
Conclusions: Nursing students were able to cope with stress in situations such as the COVID-19 pandemic. A healthy worker effect could not be ruled out. Stress and anxiety among nursing students should be considered by clinical practice preceptors and at the time students first enter the labour market.
Using Inhalation Sedation for Oral Surgery
Authors: Richards Charlotte , Boyle Carole 
Published: January 2024

With increasing waiting lists across the UK for oral surgery under general anaesthesia (GA), inhalation sedation (IS) may provide the answer for patients to be treated more quickly. The authors believe it is an underused technique for the management of anxious and medically compromised patients requiring oral surgery. This article demonstrates, with patient examples, how IS can be used effectively. CPD/Clinical Relevance: This article is relevant to general dental practitioners, oral surgeons and those working in sedation services.
Colorectal resections for malignancy: A pilot study comparing conventional vs freehand robot-assisted laparoscopic colectomy
Authors: Cawich Shamir O , Plummer Joseph Martin , Griffith Sahle , Naraynsingh Vijay 
Published: January 2024

BACKGROUND
Laparoscopic colectomy is widely accepted as a safe operation for colorectal cancer, but we have experienced resistance to the introduction of the FreeHand® robotic camera holder to augment laparoscopic colorectal surgery.
AIM
To compare the initial results between conventional and FreeHand® robot-assisted laparoscopic colectomy in Trinidad and Tobago.
METHODS
This was a prospective study of outcomes from all laparoscopic colectomies performed for colorectal carcinoma from November 29, 2021 to May 30, 2022. The following data were recorded: Operating time, conversions, estimated blood loss, hospitalization, morbidity, surgical resection margins and number of nodes harvested. All data were entered into an excel database and the data were analyzed using SPSS ver 20.0.
RESULTS
There were 23 patients undergoing colectomies for malignant disease: 8 (35%) FreeHand®-assisted and 15 (65%) conventional laparoscopic colectomies. There were no conversions. Operating time was significantly lower in patients undergoing robot-assisted laparoscopic colectomy (95.13 ± 9.22 vs 105.67 ± 11.48 min; P = 0.045). Otherwise, there was no difference in estimated blood loss, nodal harvest, hospitalization, morbidity or mortality.
CONCLUSION
The FreeHand® robot for colectomies is safe, provides some advantages over conventional laparoscopy and does not compromise oncologic standards in the resource-poor Caribbean setting.
Impact of body mass index on adverse kidney events in diabetes mellitus patients: A systematic-review and meta-analysis
Authors: Wan Jing-Fang , Chen Yan , Yao Tian-Hua , Wu Ya-Zhou , Dai Huan-Zi 
Published: January 2024

BACKGROUND
The incidence of chronic kidney disease among patients with diabetes mellitus (DM) remains a global concern. Long-term obesity is known to possibly influence the development of type 2 diabetes mellitus. However, no previous meta-analysis has assessed the effects of body mass index (BMI) on adverse kidney events in patients with DM.
AIM
To determine the impact of BMI on adverse kidney events in patients with DM.
METHODS
A systematic literature search was performed on the PubMed, ISI Web of Science, Scopus, Ovid, Google Scholar, EMBASE, and BMJ databases. We included trials with the following characteristics: (1) Type of study: Prospective, retrospective, randomized, and non-randomized in design; (2) participants: Restricted to patients with DM aged ≥ 18 years; (3) intervention: No intervention; and (4) kidney adverse events: Onset of diabetic kidney disease [estimated glomerular filtration rate (eGFR) of < 60 mL/min/1.73 m2 and/or microalbuminuria value of ≥ 30 mg/g Cr], serum creatinine increase of more than double the baseline or end-stage renal disease (eGFR < 15 mL/min/1.73 m2 or dialysis), or death.
RESULTS
Overall, 11 studies involving 801 patients with DM were included. High BMI (≥ 25 kg/m2) was significantly associated with higher blood pressure (BP) [systolic BP by 0.20, 95% confidence interval (CI): 0.15–0.25, P < 0.00001; diastolic BP by 0.21 mmHg, 95%CI: 0.04–0.37, P = 0.010], serum albumin, triglycerides [standard mean difference (SMD) = 0.35, 95%CI: 0.29–0.41, P < 0.00001], low-density lipoprotein (SMD = 0.12, 95%CI: 0.04–0.20, P = 0.030), and lower high-density lipoprotein (SMD = –0.36, 95%CI: –0.51 to –0.21, P < 0.00001) in patients with DM compared with those with low BMIs (< 25 kg/m2). Our analysis showed that high BMI was associated with a higher risk ratio of adverse kidney events than low BMI (RR: 1.22, 95%CI: 1.01–1.43, P = 0.036).
CONCLUSION
The present analysis suggested that high BMI was a risk factor for adverse kidney events in patients with DM.
Ischemic colitis induced by a platelet-raising capsule: A case report
Authors: Wang Chen-Lu , Si Ze-Kun , Liu Guo-Hong , Chen Chen , Zhao Hui , Li Lei 
Published: January 2024

BACKGROUND
Ischemic colitis (IC) is also known as colon ischemia and is caused by colon vascular occlusion or nonocclusion, which results in a reduced blood supply to the colon and is not significant enough to maintain the metabolic function of cells, leading to intestinal wall ischemia. Its main symptoms include abdominal pain, diarrhea, and bloody stool. In severe cases, intestinal gangrene, peritonitis, intestinal stenosis and even intestinal obstruction may occur. IC induced by long-term use of certain special drugs is relatively rare in clinical practice. This article describes the clinical diagnosis and treatment of a typical case and provides a new treatment idea for the treatment of IC.
CASE SUMMARY
The patient was admitted to the hospital with "abdominal pain for half a month and bloody stool with mucous and pus for 3 d" and was diagnosed with "IC". Symptomatic and supportive treatment, such as antibiotics (levofloxacin), acid inhibition and stomach protection, fluid replenishment, and intravenous nutrition, was given. The patient's colonic ulcers were considered to be related to the oral administration of platelet (PLT)-raising capsules; the patient was asked to stop PLT-raising drugs for selective review via colonoscopy, and antibiotics and mesalazine enteric-coated tablets were stopped. Under the guidance of hematology consultation, 60 mg of methylprednisolone was given in combination with PLT infusion to increase the PLT. After treatment, the patient's condition stabilized, the patient’s stool turned yellow, the patient’s symptoms improved, and the patient was allowed to leave the hospital.
CONCLUSION
PLT-raising capsules can lead to IC, so clinicians should have a full understanding of the application of these drugs in the treatment of various causes of thrombocytopenia, weigh the advantages and disadvantages, and observe patients closely.
Rare esophageal carcinoma-primary adenoid cystic carcinoma of the esophagus: A case report
Authors: Geng Li-Dan , Li Jie , Yuan Li , Du Xiao-Bo 
Published: January 2024

BACKGROUND
Esophageal adenoid cystic carcinoma (EACC) is an exceedingly rare malignant tumor of the esophagus, posing significant challenges in the clinic.
CASE SUMMARY
This report detailed the case of a 72-year-old male whose diagnosis of EACC was confirmed through postoperative histopathological examination. The patient underwent thoracoscopy-assisted radical resection of the esophageal tumor, coupled with lymph node dissection. Pathological findings revealed an adenoid cystic carcinoma infiltrating the entire layer of the muscularis propria, locally extending into the outer membrane of the esophageal fiber, involving the cardia and exhibiting no lymph node metastasis. The patient’s condition was classified as primary EACC, T3N0M0, per the American Joint Committee on Cancer (2017; 8th edition). One month after surgery, the patient received postoperative adjuvant radiation therapy.
CONCLUSION
In addressing the rarity and high potential for biopsy misdiagnosis of EACC, this study delved into its diagnostic methods and treatment.
Primary anaplastic lymphoma kinase-positive large B-cell lymphoma of the left bulbar conjunctiva: A case report
Authors: Guo Xiao-Hong , Li Chu-Bin , Cao Hui-Hui , Yang Gen-Yuan 
Published: January 2024

BACKGROUND
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (LBCL) is an aggressive and rare variant of diffuse LBCL. Herein, we report an uncommon case of stage IE extranodal ALK-positive LBCL initially originating in the bulbar conjunctiva.
CASE SUMMARY
A 63-year-old woman presented with a mass in the left bulbar conjunctiva that had persisted for six months, accompanied by swelling and pain that had persisted for 3 d. Eye examination revealed an 8 mm slightly elevated pink mass in the lower conjunctival sac of the left eye. Microscopically, the tumor was composed of large immunoblastic and plasmablastic large lymphoid cells with scattered anaplastic or multinucleated large cells. Immunophenotypically, the neoplastic cells were positive for ALK, CD10, CD138, Kappa, MUM1, BOB.1, OCT-2, CD4, CD45, EMA, CD79a, CD38, and AE1/AE3, and negative for CD20, PAX5, Lambda, BCL6, CD30 and all other T-cell antigens. The results of gene rearrangement tests showed monoclonal IGH/IGK/IGL and TCRD rearrangements. Fluorescence in situ hybridization studies did not reveal any BCL2, BCL6 or MYC rearrangements. Furthermore, Epstein-Barr virus was not detected by in situ hybridization in the lesions. Based on the histopathological and imaging examinations, the neoplasm was classified as stage IE ALK-positive LBCL. No further treatments were administered. At the 6, 15, and 21 mo postoperative follow-up visits, the patient was in good condition, without obvious discomfort. This case represents the first example of primary extranodal ALK-positive LBCL presenting as a bulbar conjunctival mass, which is extremely rare and shares morphological and immunohistochemical features with a variety of other neoplasms that can result in misdiagnosis.
CONCLUSION
Awareness of the condition presented in this case report is necessary for early and accurate diagnosis and appropriate treatment.
A Study on Rubric Development to Evaluate Writing Skill in Teaching Turkish as a Foreign Language
Authors: KAHVECİ Nevin , ŞENTÜRK Burcu 
Published: January 2024

Bu çalışmada, yabancı dil olarak Türkçe öğretiminde yazma becerisini değerlendirmede geçerli ve güvenilir bir ölçek geliştirmek amaçlanmıştır. Kurumlarda yazma sınavlarının puanlanmasında yaşanan sorunlar ve standart bir dereceli puanlama anahtarının alanda bulunmayışı bu çalışmanın çıkış noktası olmuştur. Araştırma Bartın Üniversitesi Dil Eğitim Merkezinde eğitim vermekte olan öğretmenler üzerinden yürütülmüştür. Veri toplamak için hazırlanan uzman değerlendirme formları ilgili alanyazın ve konu ile ilgili benzer ölçekler incelenerek geliştirilmiştir. Ayrıca veri toplama sürecinde uzmanlara yöneltilen görüşme soruları sonucunda elde edilen nitel bulgulardan yararlanılmıştır. 30 maddeden oluşan anket form ile alanında uzman 30 öğretmenden veri toplanmıştır. Elde edilen veriler analize tabi tutulmuştur. Araştırmada ölçeğin kapsam geçerliliğini incelemek için uzmanların görüşleri alındıktan sonra anket formlarının frekans dağılımına bakılarak %49,75’i değerlendirme sorularına katıldığını, %40,25’i tamamen katıldığını ifade ederken %8,46’sı katılmadığını,
%1,54’ü hiç katılmadığı şeklinde sonuçlar elde edilmiştir. Ölçeğin güvenirliği, puanlayıcıların verdikleri puanlar arasındaki uyumun tutarlığı incelenerek yapılmıştır. Güvenirlik tespiti için Kendall W uyuşum kat sayısı yöntemi kullanılmıştır. Analiz sonucunda geliştirilen ölçeklerin uyum katsayısı A1 seviyesi için .700, A2 seviyesi için .801, B1-B2 seviyeleri için .828, C1 seviyesi için .807 olarak bulunmuştur. Sonuçlar doğrultusunda tutarlılık katsayısı değerlerinin 1’e yaklaşması geliştirilen DPA’ların güvenirliğine kanıt oluşturmaktadır.
Yapılan analizler sonucunda A1, A2-, B1-B2, C1 seviyelerine uygun geliştirilen dereceli puanlama anahtarlarının geçerli ve güvenilir ölçme araçları olduğu yazma sınavlarını değerlendirmede kullanılabileceği söylenebilmektedir.
Large-scale pied-piping in the labeling theory and conditions on weak heads
Authors: Oda Hiromune 
Published: January 2024

Abstract
This paper discusses the concept of weak head in Chomsky’s (2015. Problems of projection: Extensions. In Elisa Di Domenico, Cornelia Hamann & Simona Matteini (eds.), Structures, strategies and beyond: Studies in honour of Adriana Belletti, 3–16. Amsterdam: John Benjamins) sense from a typological perspective. This paper first establishes a novel generalization that large-scale pied-piping is available in a language only if the language has indeterminate pronouns in Kuroda’s (1965. Generative grammatical studies in the Japanese language. Cambridge, MA: Massachusetts Institute of Technology dissertation) sense and the clause to be pied-piped is head-final. To deduce this generalization, this paper first offers a labeling theoretic account of large-scale pied-piping. It then proposes that weak heads are (i) heads that have unvalued features and (ii) morpho-phonologically weak. It is shown that the generalization is deduced from this conception of weak heads, given Inaba’s (2011. The morphosyntax of constituent ordering patterns. The Hiroshima University Studies, Graduate School of Letters 71. 43–72) generalization that head-final complementizers are generally affixal. This paper further argues that the proposed conception of weak heads also allows us to deduce Agree from Minimal Search, which is a third factor principle according to Chomsky (2013. Problems of projection. Lingua 130. 33–49), hence minimizes UG.
The impact of mitotane therapy on serum-free proteins in patients with adrenocortical carcinoma
Authors: Lech Magdalena , Ranasinghe Ruvini , Vincent Royce P , Taylor David R , Ghataore Lea , Luxton James , Lajeunesse-Trempe Fannie , Roser Pia , Drakou Eftychia E , Chuah Ling Ling , Grossman Ashley B , Aylwin Simon J B , Dimitriadis Georgios K 
Published: January 2024

Introduction
Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex. Whilst surgery is the preferred treatment, adjunctive therapy with mitotane may be offered post-surgically to minimise the risk of recurrence or, in the absence of surgery, to attenuate progression.

Aim
The objective was to evaluate the effects of mitotane treatment on serum protein concentrations in patients treated for ACC with mitotane therapy and compare this to patients with other adrenal neoplasms and a normal pregnant cohort.

Methods
Serum cortisol, thyroid function tests, adrenocorticotrophic hormone (ACTH), cortisol-binding globulin (CBG), thyroxine-binding globulin (TBG), gonadotrophins and androgens were measured on plasma and serum samples. Thirty-five patients with ACC were included, and mitotane levels were noted to be sub-/supra-therapeutic. Data were tested for normality, reported as mean ± s.d., and compared to other two cohorts using paired-sample t-test with a 5% P-value for significance and a 95% CI.

Results
Patients on mitotane therapy had a higher mean serum CBG concentration compared to the adrenal neoplasm group (sub-therapeutic: 79.5 (95% CI: 33.6, 125.4 nmol/L), therapeutic: 85.3 (95% CI: 37.1–133.6 nmol/L), supra-therapeutic: 75.7 (95% CI: −19.3, 170.6 nmol/L) and adrenal neoplasm: 25.5 (95% CI: 17.5, 33.5 nmol/L). Negative correlations between serum cortisol and CBG concentration were demonstrated within the supra-therapeutic plasma mitotane and adrenal neoplasm groups.

Conclusion
Patients with ACC and therapeutic plasma mitotane concentrations had higher serum CBG concentrations compared to those with adrenal neoplasms or pregnant women, and higher serum cortisol. Whilst there was no direct correlation with cortisol and mitotane level, the negative correlation of cortisol with CBG may suggest that the direct effect of mitotane in increasing cortisol may also reflect that mitotane has a direct adrenolytic effect.
Decreased NSD2 impairs stromal cell proliferation in human endometrium via reprogramming H3K36me2
Authors: Qin Chuan-Mei , Wei Xiao-Wei , Wu Jia-Yi , Liu Xue-Qing , Lin Yi 
Published: January 2024

In brief
The proliferation of the endometrium is regulated by histone methylation. This study shows that decreased NSD2 impairs proliferative-phase endometrial stromal cell proliferation in patients with recurrent implantation failure via epigenetic reprogramming of H3K36me2 methylation on the promoter region of MCM7.

Abstract
Recurrent implantation failure (RIF) is a formidable challenge in assisted reproductive technology because of its unclear molecular mechanism. Impaired human endometrial stromal cell (HESC) proliferation disrupts the rhythm of the menstrual cycle, resulting in devastating disorders between the embryo and the endometrium. The molecular function of histone methylation enzymes in modulating HESC proliferation remains largely uncharacterized. Herein, we found that the levels of histone methyltransferase nuclear receptor binding SET domain protein 2 (NSD2) and the dimethylation of lysine 36 on histone H3 are decreased significantly in the proliferative-phase endometrium of patients with RIF. Knockdown of NSD2 in an HESC cell line markedly impaired cell proliferation and globally reduced H3K36me2 binding to chromatin, leading to altered expression of many genes. Transcriptomic analyses revealed that cell cycle-related gene sets were downregulated in the endometrium of patients with RIF and in NSD2‑knockdown HESCs. Furthermore, RNA-sequencing and CUT&Tag sequencing analysis suggested that NSD2 knockdown reduced the binding of H3K36me2 to the promoter region of cell cycle marker gene MCM7 (encoding minichromosome maintenance complex component 7) and downregulated its expression. The interaction of H3K36me2 with the MCM7 promoter was verified using chromatin immunoprecipitation–quantitative real-time PCR. Our results demonstrated a unifying epigenome-scale mechanism by which decreased NSD2 impairs endometrial stromal cell proliferation in the proliferative-phase endometrium of patients with RIF.
ЦИФРОВИЗАЦИЯ СЕЛЬСКОГО ХОЗЯЙСТВА В ПОДДЕРЖКУ ПРОДОВОЛЬСТВЕННОЙ БЕЗОПАСНОСТИ РОССИИ
Authors: Литвинова Татьяна Николаевна , Земскова Ольга Михайловна , Тихомиров Кирилл Юрьевич 
Published: January 2024

Целью исследования является очерчивание круга наиболее перспективных областей цифровизации сельского хозяйства в поддержку продовольственной безопасности России.
Методологическую базу исследования составляет метод регрессионного анализа. С его помощью на основе статистики Росстата по регионам России в 2021 г. определены последствия цифровизации сельского хозяйства в различных областях.
Результаты исследования. Определена российская модель цифровизации сельского хозяйства, раскрывшая наиболее перспективные области цифровизации сельского хозяйства в России: финансовые расчеты в электронном виде, предоставление доступа к базам данных через Интернет, CRM-системы, SCM-системы и электронный документооборот.
Перспективы исследования связаны с конкретизацией с позиций продовольственной безопасности и количественного измерения экономической отдачи от каждой из областей цифровизации сельского хозяйства в России. Эмпирическая ценность раскрытой перспективы совершенствования практики цифровизации сельского хозяйства объясняется тем, что ориентация на нее государственных регуляторов аграрной экономики обеспечит максимальное раскрытие потенциала укрепления продовольственной безопасности России на временном горизонте 2030–2031 гг. На основе комплекса предложенных авторских рекомендаций по совершенствованию практики цифровизации сельского хозяйства в поддержку продовольственной безопасности России на временном горизонте 2030–2031 гг. сельскохозяйственные организации смогут повысить эффективность цифровизации. Предложенные рекомендации предоставили сельскохозяйственным организациям России четкое руководство к действию по цифровизации с фокусом на наиболее перспективных (с позиций экономической отдачи) областях.
РОЛЬ СТРАТЕГИЧЕСКОГО АНАЛИЗА ПРИ ОЦЕНКЕ ПЕРСПЕКТИВ РАЗВИТИЯ ПРОЕКТОВ В ГАЗОВОЙ ОТРАСЛИ
Authors: Казанин Алексей Геннадьевич , Череповицын Алексей Евгеньевич 
Published: January 2024

Цель исследования заключается в определении роли стратегического анализа для принятия управленческих решений в условиях высокого влияния факторов внешнего окружения, связанных с геополитическими, рыночными, инвестиционными, технологическими, экологическим рисками на реализацию проектов по сжижению природного газа.
Методология. Стратегический анализ сложных промышленных систем, какой является проект по сжижению природного газа и оценка основных воздействий на текущее функционирование проекта и перспективы его реализации для определения целевых задач и оценки возможности их выполнения.
Результаты исследования. Стратегический анализ в рамках реализации проектов в газовой отрасли должен иметь перманентный и системный характер. Доказана целесообразность использования классических методов стратегического анализа, которые позволяют оценить важные параметры конкурентного и динамично развивающегося рынка сжиженного природного газа. Определены ключевые риски проекта «Сахалин-2», связанного с добычей и сжижением природного газа.
Перспективы исследования заключаются в формировании комплекса количественных и качественных целевых показателей на основе целей и задач, сформулированных в рамках укрупненного стратегического анализа проектов по сжижению природного газа. Также целесообразно сосредоточиться на обосновании весовых коэффициентов рисковых событий, связанных с нестабильностью внешней среды и ограничениями по внутреннему потенциалу проектов.