bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial HER2 stimulates respiration and promotes tumorigenicity
Authors: Novotna Eliska , Milosevic Mirko , Prukova Dana , Magalhaes‐Novais Silvia , Dvorakova Sarka , Dmytruk Kristina , Gemperle Jakub , Zudova Dagmar , Nickl Tereza , Vrbacky Marek , Rosel Daniel , Filimonenko Vlada , Prochazka Jan , Brabek Jan , Neuzil Jiri , Rohlenova Katerina , Rohlena Jakub 
Published: January 2024

AbstractBackgroundAmplification of HER2, a receptor tyrosine kinase and a breast cancer‐linked oncogene, is associated with aggressive disease. HER2 protein is localised mostly at the cell membrane, but a fraction translocates to mitochondria. Whether and how mitochondrial HER2 contributes to tumorigenicity is currently unknown.MethodsWe enriched the mitochondrial (mt‐)HER2 fraction in breast cancer cells using an N‐terminal mitochondrial targeting sequence and analysed how this manipulation impacts bioenergetics and tumorigenic properties. The role of the tyrosine kinase activity of mt‐HER2 was assessed in wild type, kinase‐dead (K753M) and kinase‐enhanced (V659E) mtHER2 constructs.ResultsWe document that mt‐HER2 associates with the oxidative phosphorylation system, stimulates bioenergetics and promotes larger respiratory supercomplexes. mt‐HER2 enhances proliferation and invasiveness in vitro and tumour growth and metastatic potential in vivo, in a kinase activity‐dependent manner. On the other hand, constitutively active mt‐HER2 provokes excessive mitochondria ROS generation, sensitises to cell death, and restricts growth of primary tumours, suggesting that regulation of HER2 activity in mitochondria is required for the maximal pro‐tumorigenic effect.Conclusionsmt‐HER2 promotes tumorigenicity by supporting bioenergetics and optimal redox balance.
The applicability of the central line‐associated bloodstream infection (CLABSI) criteria for the evaluation of bacteremia episodes in pediatric oncology patients
Authors: van den Bosch Ceder H. , Frakking Florine N. J. , Loeffen Yvette G. T. , van Tinteren Harm , van der Steeg Alida F. W. , Wijnen Marc H. W. A. , van de Wetering Marianne D. , van der Bruggen Jan‐Tom 
Published: January 2024

AbstractBackgroundThe aim of this study was to investigate the applicability of the central line‐associated bloodstream infection (CLABSI) criteria of the Centers for Disease Control and Prevention in pediatric oncology patients.MethodsBacteremia episodes from 2020 to 2022 from a prospective cohort of pediatric oncology patients with a central venous catheter were included. Episodes were classified by three medical experts following the CLABSI criteria as either a CLABSI or non‐CLABSI (i.e., contamination, other infection source, or mucosal barrier injury‐laboratory confirmed bloodstream infection (MBI‐LCBI)). Subsequently, they were asked if and why they (dis)agreed with this diagnosis following the criteria. The primary outcome was the percentage of episodes where the experts clinically disagreed with the diagnosis given following the CLABSI criteria.ResultsOverall, 84 bacteremia episodes in 71 patients were evaluated. Following the CLABSI criteria, 34 (40%) episodes were classified as CLABSIs and 50 (60%) as non‐CLABSIs. In 11 (13%) cases the experts clinically disagreed with the diagnosis following the CLABSI criteria. The discrepancy between the CLABSI criteria and clinical diagnosis was significant; McNemar's test p < .01. Disagreement by the experts with the CLABSI criteria mostly occurred when the experts found an MBI‐LCBI a more plausible cause of the bacteremia than a CLABSI due to the presence of a gram negative bacteremia (Pseudomonas aeruginosa n = 3) and/or mucositis.ConclusionsA discrepancy between the CLABSI criteria and the evaluation of the experts was observed. Adding Pseudomonas aeruginosa as an MBI pathogen and incorporating the presence of mucositis in the MBI‐LCBI criteria, might increase the applicability.
Toxic language detection: A systematic review of Arabic datasets
Authors: Bensalem Imene , Rosso Paolo , Zitouni Hanane 
Published: January 2024

AbstractThe detection of toxic language in the Arabic language has emerged as an active area of research in recent years, and reviewing the existing datasets employed for training the developed solutions has become a pressing need. This paper offers a comprehensive survey of Arabic datasets focused on online toxic language. We systematically gathered a total of 54 available datasets and their corresponding papers and conducted a thorough analysis, considering 18 criteria across four primary dimensions: availability details, content, annotation process, and reusability. This analysis enabled us to identify existing gaps and make recommendations for future research works. For the convenience of the research community, the list of the analysed datasets is maintained in a GitHub repository.
Corporate social responsibility, carbon footprints and stock market valuation
Authors: Benkraiem Ramzi , Qureshi Maria , Saeed Asif , Zopounidis Constantin 
Published: January 2024

AbstractThe emission of greenhouse gases (GHG), particularly carbon dioxide (CO2), within the atmosphere poses serious threats to society and the environment. In this paper, we examine the effect of carbon dioxide (CO2) emissions on the association between corporate social responsibility (CSR) and stock valuation. Using a sample of listed non‐financial US firms from 2002 through 2018, we find that CO2 emission plays a moderating role in reshaping the CSR‐stock valuation nexus. Further analysis showed that our results are robust for using alternate proxies of CSR, CO2, additional control and methods to alleviate endogeneity concerns. Additionally, we explored how increasing carbon footprints reshape this association only for firms with strong governance structures. Overall, our results indicate that the positive impact of CSR on stock valuation is overlaid by corporate CO2 emission. The practical and theoretical insights of this study were explored.
Bluehead chub Nocomis leptocephalus hosts exploit selfish‐herd benefits from their heterospecific nest associates
Authors: Betts Madison M. , Abaid Nicole , Maurakis Eugene G. , Frimpong Emmanuel A. 
Published: January 2024

Abstract

Prey species often congregate in groups to detect and evade predators, yet not all group members benefit equally. We observed the nesting aggregations of bluehead chub (Nocomis leptocephalus), where one nest “hosts” as many as several hundred “nest associates.” We predicted that the male chub exploits the aggregation in a manner consistent with selfish‐herd theory – specifically, by locating itself in the safest location within the aggregation (the centre) and using the aggregation to reduce its own vigilance requirements.

Vigilance was measured as the time it took the host (male) chub, first chub female and first individual of each associate species to return to the nest under differing associate abundances (hypothesised to be inversely related to risk) following a simulated predator scare. Spatial position was investigated by digitising host movement and overlaying it with the aggregation and nest's spawning pit area.

We used information theoretic statistics to analyse the effect of aggregation characteristics on the return time of chub and their nest associates. The best‐supported model included both species composition and abundance (inverse of risk) as predictors of return time. Hosts returned last under nearly all scenarios and the aggregation as a whole took longest to return in high‐risk environments. The 95% and 99% confidence ellipses of host spatial position contained the centroids of the aggregation and spawning pits, respectively, for all nests analysed (n = 11).

We conclude that the host locates itself at the centre of both the aggregation and the spawning pit area of the nest, and that the host uses the aggregation to reduce its own vigilance requirements. These results support our hypothesis that hosts use their nest associates to disproportionately decrease their risk of predation during spawning.

This is the first study to show any mixed‐species fish spawning aggregation as a selfish shoal, and to identify bluehead chub as a selfish participant in the mutualistic reproductive interactions that they host.
Mechanical property and failure mechanism of coated Al2O3f/SiO2 composites by acoustic emission technology (AE)
Authors: Yang Xiang , Chen Mo , Kun Chen , Zhou Zheng , Zhi‐hang Peng , Chen‐cheng Sun , Wen‐jun Wu , Jin Wen , Jian‐hui Cao 
Published: January 2024

AbstractAl2O3f/SiO2 composites were fabricated by sol–gel process, with a density of 2.22 g/cm3, pyro carbon coating prepared via chemical vapor deposition. The interfacial bonding strength between the fiber and matrix was weakened, and the brittle fracture characteristics of the fiber under a high‐temperature environment were improved, ensuring the integrity and reliability of the structure. The mechanical property and failure mechanism of the composites were investigated using acoustic emission technology (AE). In the tensile test, microcracks first appeared in the sample matrix, followed by matrix damage, fiber matrix debonding, and partial fiber fracture near the peak load. It was worth noting that many fibers remained undamaged when the load suddenly declined. As the loading continued, these fibers were fully pulled out and consequently loaded until they gradually broke. In the shear test, the load increased to its peak and decreased rapidly, and the proportion of the AE signal generated was extremely small (≤.01). Owing to the brittleness of the matrix under shear force, the crack easily expanded along the interlayer instability such that the sample first showed significant interlayer damage.
Correlation study of random deposition for WC–12Co multiparticles on the TC18 substrates
Authors: Han Xing , Li Chang , Li Siyu , Chen Xinxue 
Published: January 2024

AbstractThe TC18 titanium alloy as an aviation landing gear material is famous for its high strength and hardenability. However, under the influence of the harsh service environment, its corrosion resistance is relatively poor. WC–12Co ceramic material is one of the most widely used surface strengthening materials, and the coatings are often produced by high velocity oxygen fuel (HVOF) thermal spraying. In the spraying, the deposition state of particles directly affects the quality and strengthening ability of coating. This study combined the correlation of flow field calculation and impact process of particles, and the particle flight characteristics were analyzed in the three‐dimensional HVOF spraying. The change law for temperature and velocity of particles was explored by changing the spraying distance, oxygen/fuel (O/F) ratio, and particle size. Based on the calculation results of flow field, a three‐dimensional random deposition model of WC–12Co multiparticle was established by the coupled Euler–Lagrange method, and the crystal inhomogeneity was introduced by the Voronoi method. Compared the flattening rate and spreading degree of particles deposition, the evolution law of temperature and stress–strain fields for coating and substrate during the deposition was revealed.
Analysis and prospect of thermodynamic behavior of aluminosilicate solid waste during ceramization
Authors: Jiang Mengting , Chen Wei , Liu Yuling , Du Yong , Deng Tengfei 
Published: January 2024

AbstractAluminosilicate solid waste, primarily comprising red mud, coal gangue, fly ash, and tailings, is characterized by high annual production, low comprehensive utilization rate, and significant environmental damage. Currently, there is an urgent need for effective methods to manage and valorize aluminosilicate solid wastes. Thermodynamic investigations enable the assessment of phase transition behaviors, process conditions (such as temperature and pressure), and the direction and feasibility of reactions. Moreover, thermodynamics can predict the composition of resulting products and reveal the reaction mechanisms. All the aforementioned issues are instrumental in refining solid waste treatment processes and achieving efficient use of resources. Therefore, to promote the application of aluminosilicate solid waste, this paper describes the predictive and guiding functions of thermodynamics in the utilization of solid waste, focusing on three aspects: composition design, ceramization, and process optimization. Additionally, current challenges and future trends are discussed herein.
Sm and Mn doped enhancing the electrical properties of .68PMN–.32PT relaxor ferroelectric thin films
Authors: Chen Liang , Zhao Changxing , Jiang Peng , Xie Shuhong , Pan Kai 
Published: January 2024

Abstract(1−x)Pb(Mg1/3Nb2/3)O3–xPbTiO3 (PMN–PT) has attracted attention due to its excellent electrical properties as a typical relaxor ferroelectric material. High‐quality Mn–Sm co‐doped 0.68PMN–0.32PT thin films were synthesized on the Pt/Ti/SiO2/Si substrates by sol–gel based on spin coating method. The results show that 1 mol% Mn–2 mol% Sm co‐doped PMN–PT thin films have high dielectric constant (εr ∼ 1895) and relatively low dielectric loss (tanδ ∼ .039) at 1 kHz. They also show superior ferroelectric polarization (Pmax ∼ 53.71 μC/cm2, Pr ∼ 30.85 μC/cm2) and high dielectric breakdown strength (∼1656.6 kV/cm), which are primarily due to the low leakage current density (∼10−7 A/cm2). This work suggests a practical approach to enhance the dielectricity, piezoelectricity, and ferroelectricity of PMN–PT thin films.
Two‐year follow‐up comparing Rezūm therapy versus bipolar transurethral resection of the prostate for treating benign prostatic hyperplasia. A prospective randomized study
Authors: Samir Mohamed , Elaal Abd Allah Abd , Gad Khaled Abdel Sattar , Basyony Mohamed Wagieh 
Published: January 2024

ObjectiveComparison of the efficacy and safety of Rezūm therapy and bipolar transurethral resection of prostate (B‐TURP) for the management of benign prostatic hyperplasia (BPH) of 50–120 g size.MethodsOne hundred patients with BPH who met the inclusion criteria were included and split into two equal groups to undergo Rezūm therapy or B‐TURP. The two groups were compared for efficacy using international prostate symptom score (IPSS), quality of life (QoL), maximum urinary flow rate (Qmax), operative time, catheter time, hospital stay, post‐void residual urine (PVR), prostate‐specific antigen (PSA), and residual prostate size and safety using the incidence of complications.ResultsRezūm significantly ameliorated IPSS from the baseline score by 55.3%, QoL by 50%, Qmax by 62.5%, International Index of Erectile Function (IIEF) by 7.1%, PVR by 50%, residual prostate size by 28.1% and PSA by 42% at 2 years. Meanwhile, the improvement in B‐TURP was significantly higher than Rezūm group, Rezūm therapy had a significantly shorter duration of operative time and hospital stay. Also, it had fewer complications in comparison with B‐TURP.ConclusionsRezūm is a minimally invasive procedure that provides significantly improved symptomatic relief of BPH and quality of life with preservation of erectile and ejaculatory functions. However, it is not as effective as B‐TURP.
Using a trauma‐informed care framework to explore social climate and borderline personality disorder in forensic inpatient settings
Authors: Rodwell Devon , Frith Hannah 
Published: January 2024

AbstractTensions between therapeutic and security needs on forensic wards can create a social climate which is challenging for both mental health nurses and patients. Social climate refers to the physical, social and emotional conditions of a forensic ward which influence how these environments are experienced. For patients with borderline personality disorder (BPD), previous trauma means that the social climate of forensic settings may be experienced as retraumatising, negatively impacting the outcomes and wellbeing of both patients and mental health nurses. Trauma‐informed care (TIC) has been offered as a contemporary framework for mental health nursing in inpatient units which aims to create a therapeutic social climate. In this critical review, we drew widely on literatures examining the social climate in forensic settings, the relationships between patients with BPD and staff (including mental health nurses), and the experiences of patients with BPD in forensic and inpatient settings to draw out the implications of scrutinising these literatures through the lens of TIC. Attending to the physical, social and emotional conditions of social climate in secure settings highlights how forensic wards can mirror trauma experiences for patients with BPD. Implementing TIC in these contexts has the potential to evoke positive shifts in the social climate, thus reducing the risk of retraumatisation and leading to improved outcomes for patients and staff.
Effect of vitamin D on clinical outcomes in patients with thermal injury
Authors: Pirdastan Sepide , Mahdavi Roshan Marjan , Mobayen Mohammadreza , Asadzadegan Reza , Ebrahim Ghafari Mohammad , Mazhari Seyed Amirhossein , Sadeghi Mahsa , Bagheri Toolaroud Parissa , Alizadeh Otaghvar Hamidreza 
Published: January 2024

AbstractEvaluating complications and mortality risks in burn patients is crucial for effective treatment planning and improving survival rates. This study investigated the relationship between the serum vitamin D level and the clinical outcomes of adult burns patients. This was a prospective cohort of adult patients hospitalized due to thermal burns at a burn centre in the north of Iran. Based on the level of 25 hydroxyvitamin D measured upon admission, patients were divided into two groups of patients with sufficient 25 hydroxyvitamin D level and insufficient 25 hydroxyvitamin D level. Descriptive statistics were used for baseline demographics. Univariate analysis was conducted using Mann–Whitney U, Chi‐square, independent samples, and Fisher's exact tests. A multivariate logistic regression was performed to adjust for the effects of confounding variables. Statistical analyses were conducted using SPSS 28.0 software. A total of 220 patients were included in the study. The average total body surface area burned was 30.52 ± 9.34. Patients with insufficient vitamin D levels had longer hospital stays (12.53 vs. 11.45) and longer stays in the intensive care unit (ICU) (3.32 vs. 2.40) than those with appropriate vitamin D levels. Participants with insufficient vitamin D levels exhibited a numerically higher incidence of infections than those with adequate levels (p < 0.05). The multivariate regression found that vitamin D deficiency levels were associated with increased infection rates and prolonged hospital stay. This study suggests that vitamin D deficiency is a significant risk factor for adverse clinical outcomes in burn patients. Further research is needed to confirm these associations and to explore potential interventions to optimize vitamin D status in this patient population.
Application of maple leaf‐shaped flap combined with negative pressure wound therapy in the perianal circular skin defect reconstruction
Authors: Dai Haiying , Wang Yuchong , Xu Jianguo , Lv Chuan , Dong Jie , Sun Mengyan , Chen Kexin , Xiao Yuai , Wu Minliang , Xue Chunyu 
Published: January 2024

AbstractWe aimed to explore the efficacy of maple leaf‐shaped flap in the repair of perianal circular skin defect. This study is a retrospective review of patients with perianal circular skin defect after skin tumour resection and repaired with maple leaf‐shaped flap. Patients included in this study were admitted in our department between January 2010 and January 2023. A standardized data collection template was used to collect related variables. The design and surgical procedures of maple leaf‐shaped flap are carefully described in this study. Negative pressure wound therapy (NPWT) was applied to assist wound healing postoperatively. Twenty‐seven patients were included in this study. The average wound size after tumour resection measured 4 × 5 cm2–10 × 10 cm2. The circular skin defect was repaired by maple leaf‐shaped flap, and NPWT was used after surgery. Twenty‐five patients achieved primary wound healing and flaps were well‐survived. Slight infection occurred in two patients, and both were cured after dressing change. During the follow‐up period of 6–24 months, no tumour recurrence occurred. The perianal morphology can be well‐restored by maple leaf‐shaped flap, and the defecation control function of anus was not impaired. The application of maple leaf‐shaped flap and NPWT is a promising way in the repair of perianal circular skin defect with little complication and satisfying outcomes.
A meta‐analysis on the impact of spinal cord stimulation on post‐operative wound healing in patients with multiple sclerosis
Authors: Cai Youde , Zheng Xiong , Gan Fang 
Published: January 2024

AbstractSpinal cord stimulation (SCS) has emerged as a potential therapeutic tool for various chronic conditions, but its efficacy in post‐operative wound healing for multiple sclerosis (MS) patients has not been comprehensively understood. This meta‐analysis aimed to evaluate the impact of SCS on post‐operative wound healing and scar formation in MS patients. A systematic literature review identified seven studies for inclusion. We focused on wound healing as measured by the redness, edema, ecchymosis, discharge, approximation (REEDA) scale 1 week post‐operation and scar formation assessed by the Manchester Scar Scale (MSS) 3 months post‐operation. The results demonstrated a significant improvement in wound healing in the SCS group, with a standard mean difference (SMD) of −5.82 (95% confidence interval [CI]: [−7.56, −4.09], p < 0.01) on the REEDA scale. For scar formation, the SCS group showed a notable reduction in MSS scores, with an SMD of −10.06 (95% CI: [−14.53, −5.58], p < 0.01). These findings underscore the potential of SCS as an adjunct therapy in enhancing surgical recovery in MS patients, pointing towards its broader applications in post‐operative care.
Sintering of large‐sized and near‐stoichiometric BNT ceramics with enhanced dielectric and electrostrictive properties
Authors: Guo Huilu , Zhu Minmin , Zhao Yida , Du Zehui 
Published: January 2024

AbstractSintering for large‐sized, stoichiometric Bi0.5Na0.5TiO3 (BNT) ceramics is of great challenge due to the loss of volatile Bi/Na at A‐site of perovskite structure. In this work, BNT ceramic tile with the size of ∼10 × 10 cm2 and near‐stoichiometric composition has been successfully fabricated by Isobam‐assisted gelcasting process, followed by sintering with 1150°C calcined power bed. The powder bed used and sintering duration were found to have a great influence on the formation of the Na‐deficient phase (Bi4.5Na0.5Ti4O15) in the ceramics, and the strategies to eliminate it have been explored. The obtained ceramics exhibit a dielectric constant/loss of 673.6/0.039 at 1 kHz, as well as an electrostrictive strain of ∼0.07% which corresponds to a converse piezoelectric constant of 105.2 pm/V. Our work thus provides an effective approach to prepare large‐sized and stoichiometric BNT ceramics.
Effect of P/Al ratio on the X‐ray induced darkening in Dy‐doped silica glasses at visible wavelengths
Authors: Sun Yan , Ma Juping , Shao Chongyun , Guo Mengting , Wang Xin , Yu Fei , Chen Shubin , Yu Chunlei , Liao Meisong , Hu Lili 
Published: January 2024

AbstractIn this work, we study the mechanisms of X‐ray induced darkening in the Dy/Al/P co‐doped silica glasses at visible wavelengths and explore the role of P/Al ratio played in the enhancement of irradiation resistance. The absorption, emission spectra and lifetime, Raman, and electron paramagnetic resonance spectra of pristine and irradiated Dy‐silica glasses as a function of P/Al ratio were measured and analyzed. The Si‐related defects (Si‐E′ and non‐bridge oxygen hole center), Al‐related defects (Al‐E′ and Al‐related oxygen hole center), P‐related defects (P‐OHC and P2), and Dy2+ ions were studied and analyzed. Results demonstrate that increasing P/Al is efficient to suppress the photodarkening in Dy‐silica glasses at visible wavelengths. Results imply that Dy‐silica glasses with P/Al > 1 may be a promising candidate for efficient visible fiber lasers operated at around 575 nm wavelength.