bluuebunny/crossref_metadata_2025_split huggingface dataset:
Docking and Molecular Dynamic Simulation of ApoE isoforms to Trem2
Authors: Lehrer Steven , Rheinstein Peter 
Published: January 2025

Abstract

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with limited therapeutic options. The interaction between Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), a critical microglial receptor, and Apolipoprotein E (ApoE), the strongest genetic risk factor for late-onset AD, plays a pivotal role in modulating immune responses in the brain. However, the structural and functional dynamics of TREM2-ApoE isoform interactions (ε2, ε3, and ε4) remain incompletely understood.
Methods: Protein-protein docking using ClusPro was employed to model the interactions between wild-type TREM2 and the three ApoE isoforms (ε2, ε3, ε4) using crystallographic structures. Stability and structural dynamics of these complexes were analyzed using molecular dynamics simulations performed in GROMACS. Key parameters assessed included Root Mean Square Deviation (RMSD) for structural stability and Radius of Gyration for compactness.
Results: Docking results indicated that ApoE ε3 had the lowest energy-weighted score, suggesting the most stable docking conformation. However, molecular dynamics simulations revealed that ApoE ε4 exhibited greater interaction robustness despite lower compactness. ApoE ε2 demonstrated the least stable interaction, characterized by significant variability in structural compactness. These findings highlight isoform-specific differences in TREM2-ApoE interactions, with ApoE ε4 exhibiting unique binding characteristics consistent with its strong association with AD risk.
Conclusion: The therapeutic potential of modulating TREM2-ApoE interactions warrants exploration. Small molecules or biologics that selectively enhance or inhibit these interactions could represent novel strategies for mitigating AD risk or progression, particularly in individuals carrying the ApoE ε4 allele.
Minimally invasive surgery for Craniopharyngioma in a 10-year-old pediatric patient
Authors: Cavalheiro Sergio , Quiróz José Antonio Rangel , Dastoli Patricia Alessandra , Kim Isaque Hyung Tong , Suzuki Fernando Seiji , Costa Marcos Devanir Silva da 
Published: January 2025

Abstract

Craniopharyngiomas are benign, slow-growing tumors in the sellar and para-sellar regions of the central nervous system, with a prevalence of about 2 per 100,000.
Symptoms include headaches, visual disturbances, and endocrine dysfunctions like growth retardation and delayed puberty. Diagnosis involves clinical, radiological, and histological evaluations.
Treatment typically includes surgical resection, with the approach depending on hypothalamic invasion, and may involve postoperative radiotherapy and hormone restitution.
In this article, we present a summary of a case of surgery in a pediatric patient with a craniopharyngioma using microsurgery and neuroendoscopy together to perform minimally invasive surgery through the foramen of Monroe. We can conclude that good management of this pathology depends on the extent of resection, tumor location and size, preoperative endocrine status, and adequate follow-up of these patients by a multidisciplinary team.
Ethics committee approval was not required to perform the surgical procedure on the patient. The patient's parents gave informed consent for the surgery and gave verbal consent for the publication of their video surgery.
Mental Health of Educators: A Pilot Study on Personality and Physical Activity as Correlates of Teachers’ Occupational Burnout
Authors: Wilczyńska Dominika , Hejła Marcelina 
Published: January 2025

The study explores burnout among 73 school teachers, examining associations with personality, physical activity, and differences based on age, gender, and specialization. Utilizing the NEO-FFI Personality Inventory, Maslach Burnout Inventory, and International Physical Activity Questionnaire, it revealed significant correlations between personality traits (excluding openness) and all burnout dimensions. Notably, younger teachers exhibited higher depersonalization levels than their older counterparts. Given teachers’ pivotal role in student development, researching occupational burnout is crucial – especially in the post-pandemic era. Understanding these dynamics is essential for fostering a healthy educational environment and ensuring overallstudent well-being.
The Polish Association of Suicidology’s Contribution to the Advancement of Scholarly Publications in the Field of Suicidology: The Annual Journal Suicydologia
Authors: Czabański Adam 
Published: January 2025

The Polish Association of Suicidology (Polskie Towarzystwo Suicydologiczne [PTS]) has played a major role in raising awareness of the dangers of suicidal behavior in society. One of the objectives in establishing the PTS was publishing. The purpose of this article is to describe the contribution of the PTS to the advancement of publications in the field of suicidology, based on the example of the annual journal Suicydologia.The journal was printed in ten volumes between 2005 and 2018. The authors included members of the Polish Association of Suicidology as well as guest authors who were invited from all over Poland. These were professionals in many fields and disciplines, from the medical and health sciences to social science research. It seems that the publication of papers in the field of suicidology in Suicydologia contributed to bringing together this scientific community, spreading knowledge about the threat of suicidal behavior and designing preventive measures to mitigate suicide.
Syzygium cumini-Mediated NPs Exhibiting Antibacterial, Anti-Motility,
and Anti-Biofilm Potential against Multi-Drug Resistant Clinical
Nosocomial Pathogens
Authors: Diksha Diksha , Pai Manju Ohri , Gupta Pratima , Badoni Gaurav , Negi Shailender , Anand Priyal , Das Jayanta , Madhav Kunal , Verma Sahil , Banerjee Uttam Chand , Kalita Deepjyoti 
Published: January 2025

Introduction:
Multidrug resistance in nosocomial pathogens is now a serious problem
in the health care system and causes the majority of morbidity and death worldwide. The
current landscape of antibiotic failures encourages researchers to look for plant-based (green
synthesized) nanoparticles (NPs). Therefore, the present study aims to synthesize silver NPs
(AgNPs) using the leaf extract of Syzygium cumini (S. cumini) and assess their antibacterial,
anti-motility, and anti-biofilm potential against two multi-drug resistant (MDR) clinical isolates,
i.e., P. aeruginosa and A. baumannii.

Methodology:
Optimization of reaction parameters for NPs synthesis was carried out using a
UV-Vis spectrophotometer. After optimization, these NPs were characterized through UV-Vis,
Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), XRay
Diffraction (XRD), Selected Area Electron Diffraction (SAED), and ThermoGravimetric
Analyzer (TGA). These NPs were then checked for antibacterial, anti-motility, and anti-biofilm
activity.

Results:
The spectrum of optimized AgNPs was noticed at 432 nm, displaying a bell-shaped
curve under UV-Vis spectroscopy. TEM images showed biosynthesized NPs have a spherical
shape and 15-20 nm diameter. The FT-IR study has revealed the presence of phenolics, aromatics,
and alkyne groups in the synthesized NPs. These biosynthesized AgNPs were processed for
antibacterial, anti-motility, and anti-biofilm activity. Results showed that AgNPs exhibit good
antibacterial activity. The effect of AgNPs against P.aeruginosa and A. baumannii showed a
substantial reduction in motility patterns and biofilm architecture. A one-way ANOVA statistical
test was used that displayed a significant difference (p-value<0.001) in MIC, motility, and biofilm
inhibition assay.

Conclusion:
Based on the findings, AgNPs showed promising antibacterial, anti-motility, and
antibiofilm activity against both MDR clinical strains. However, identifying the active compound
and using its NPs in vivo and in animal experiments may add to their future applicability.
Revolutionizing Drug Delivery: A Design Professional's Approach to Drug-loaded Transferosomal Vesicles for Transdermal Use
Authors: Subramaniyan Gopinath , Shaik Rubina , Ramana Bachu Venkata , A Meriton Stanley , Srinivasan Devasena 
Published: January 2025

Aim:
This study aimed to develop and evaluate lornoxicam (LXM) and thiocolchicoside
(TCS) transferosomal transdermal patches.

Background:
Oral administration of LXM and TCS can lead to gastric irritation, necessitating alternative
delivery methods for pain and inflammation relief. Incorporating LXM & TCS into transferosomes
within a transdermal patch offers a potential solution.

Objective:
The objective of this study is to develop and evaluate transferosomal transdermal patches
containing LXM and TCS, incorporating Aloe vera leaf mucilage (AVLM) and lime oil (LO) as
permeability enhancers. The aim is to enhance the skin permeation of these drugs while mitigating
gastric irritation associated with their oral administration.

Method:
Transferosomes were made by the thin film hydration tactic, with nine formulations based
on three independent variables: phosphatidylcholine, span 80, and sonication time. Entrapment efficiency
and drug release at 6th h were assessed as dependent variables. The optimized combination
was then formulated into transdermal patches via central composite design, evaluating the impact of
AVLM and LO on lornoxicam discharge and other physicochemical properties.

Results:
The average weight and thickness of the patches ranged from 7.52±0.75 to 8.07±0.11g and
from 1.69±0.01 to 1.82±0.02mm, respectively, representing minimal variance. The LXM/TCS content
homogeneity ranged from 92.84±3.55 to 94.07±4.61% for LXM and from 90.17±1.98 to
93.18±2.98% for TCS, demonstrating robust uniformity. Higher proportions of phosphatidylcholine
and span 80, along with lesser sonication time, led to improved entrapment of lornoxicam. In vitro,
discharge studies demonstrated optimal discharge with a higher proportion of phosphatidylcholine, a
medium proportion of span 80, and a longer sonication time. The transferosomal patches exhibited
zero-order discharge kinetics, with LXM & TCS discharge % at 24, 48, and 72 h.

Conclusion:
The study concludes that formulation TDP-8, which incorporates 3g of Aloe vera leaf
mucilage (AVLM) and lime oil (LO) as permeability enhancers, demonstrated favorable discharge
characteristics. This indicates its potential as an effective transdermal delivery system for LXM and
TCS, offering a promising substitute for pain and inflammation relief while minimizing gastric irritation.
The study succeeded in developing and evaluating transferosomal transdermal patches for
LXM and TCS, providing an alternative delivery method that minimizes gastric irritation.
Las Tic desde la perspectiva de trabajo social, retos para los proyectos pedagógicos transversales en un colegio de zona de frontera
Authors: Montero Ferreira Milton Alier , Casadiego Estevez Yeiny Alexandra 
Published: January 2025

El presente artículo es resultado de la investigación “Transversalidad desde el uso de TIC en la Institución Educativa Jaime Garzón, en la ciudad de Cúcuta”, hace parte de los procesos que adelanta el Grupo de Investigación de Trabajo Social GITS y el Semillero de Investigación en Transformaciones Sociales SITSO de la Universidad Francisco de Paula Santander; responde a la línea de investigación Trabajo Social y acción socio educativa. El objetivo general de la investigación es: reconocer los proyectos pedagógicos transversales desde el uso de TIC en la Institución Educativa Jaime Garzón; la metodología se desarrolló desde un enfoque cualitativo con un diseño de investigación acción participativa, basado en un muestreo por conveniencia.
En los resultados se destacan cuatro subcategorías enfocadas a los retos de los proyectos pedagógicos transversales desde el uso de TIC para el Trabajo Social: dinamización del sistema socio familiar, transformaciones pedagógicas, fortalecimiento de la autonomía y, apropiación de competencias del uso de las TIC. En conclusión, se reconoce que las TIC son fundamentales para fortalecer los proyectos pedagógicos transversales, pero, no se están utilizando lo suficiente para generar competencias en los estudiantes.
Dampak Metode Outing Class Learning Berbantuan Media Lingkungan Hidup Terhadap Kompetensi Pengetahuan IPAS Kelas IV
Authors: Suciati Ni Ketut 
Published: January 2025

Kompetensi pengetahuan peserta didik dan minat belajarnya masih tergolong rendah. Salah satu penyebabnya yakni guru hanya terfokus kepada kemampuan siswa untuk mengingat dan menghafal. Penelitian ini bertujuan untuk menganalisis metode outing class learning berbantuan lingkungan hidup terhadap kompetensi pengetahuan IPAS Di Kelas IV. Penelitian ini menggunakan desain eksperimen semu (quasi eksperimenr design) dengan rancangan desain penelitian bentuk Nonequivalent Control Group Design dengan populasi siswa kelas IV SD yang berjumlah 208 siswa. Pengumpulan data pada penelitian ini menggunakan metode tes bentuk pilihan ganda. Data hasil penelitian dianalisis dengan teknik analisis statistik deskriptif dan statistik inferensial (uji-t). Hasil analisis hipotesis diperoleh thitung sama dengan 7,563 lebih dari ttabel sama dengan 2,015 berdasarkan taraf signifikansi 5% dan dengan dk sama dengan 44 (n1+n2-2), sehingga H0 ditolak dan H1 diterima. Simpulan penelitian menunjukkan metode outing class learning berbantuan media lingkungan hidup berpengaruh terhadap kopetensi pengetahuan IPAS siswa di SD. Implikasi penelitian merupakan metode pembelajaran outing class learning ini tidak hanya digunakan untuk pembelajaran dengan muatan IPAS saja, melainkan dapat digunakan untuk muatan pembelajaran lainnya.
Forecasting the Dynamics of Summer Phytoplankton Species based on Satellite Data Assimilation Methods
Authors: Belova Yu. V. , Filina A. A. , Chistyakov A. E. 
Published: January 2025

Introduction. Mathematical tools integrated with satellite data are typically employed as the primary means for studying aquatic ecosystems and forecasting changes in phytoplankton concentration in shallow water bodies during summer. This approach facilitates accurate monitoring, analysis, and modeling of the spatiotemporal dynamics of biogeochemical processes, considering the combined effects of various physicochemical, biological, and anthropogenic factors impacting the aquatic ecosystem. The authors have developed a mathematical model aligned with satellite data to predict the behavior of summer phytoplankton species in shallow water under accelerated temporal conditions. The model describes oxidative[1]reduction processes, sulfate reduction, and nutrient transformations (phytoplankton mineral nutrition), investigates hypoxia events caused by anthropogenic eutrophication, and forecasts changes in the oxygen and nutrient regimes of the water body.Materials and Methods. To simulate the population dynamics of summer phytoplankton species correlated with satellite data assimilation methods, an operational algorithm for restoring water quality parameters of the Azov Sea was developed based on the Levenberg-Marquardt multidimensional optimization method. The initial distribution of phytoplankton populations was obtained by applying the Local Binary Patterns (LBP) method to satellite images of the Taganrog Bay and was used as input data for the mathematical model.Results. Using integrated hydrodynamic and biological kinetics models combined with satellite data assimilation methods, a software suite was developed. This suite enables short- and medium-term forecasts of the ecological state of shallow water bodies based on diverse input data correlated with satellite information.Discussion and Conclusion. The conducted studies on aquatic systems revealed that improving the accuracy of initial data is one mechanism for enhancing the quality of biogeochemical process forecasting in marine ecosystems. It was established that using satellite data alongside mathematical modeling methods allows for studying the spatiotemporal distribution of pollutants of various origins, plankton populations in the studied water body, and assessing the nature and scale of natural or anthropogenic phenomena to prevent negative economic and social consequences.
The Effect of Nutritioning Interval on Automatic Drip Hydroponic System on Growth and Production of Three Varieties of Lettuce (Lactuca sativa L.)
Authors: Ristiyana Suci , Fanata Wahyu Indra Duwi , Saputra Tri Wahyu , Purnamasari Ika , Dewanti Parawita , Taufik Rahadian Falqi 
Published: January 2025

Lettuce (Lactuca sativa L.) is a leaf vegetable that has a high level of consumer demand and commercial value and can be cultivated using a combination of hydroponic substrate and drip irrigation methods. This research aims to determine the effect of the time interval for providing nutrients on the growth and harvest results of three lettuce plant varieties. Plants were cultivated on cocopeat and husk charcoal media (ratio 1:3) and arranged using a Randomized Block Design (RAK) consisting of two treatments. The first treatment is the nutritional interval which consists of an interval of 2 hours with a discharge of 17 ml (I1), 3 hours with a discharge of 25 ml (I2), and 4 hours using a discharge of 34 ml (I3). The second treatment is the plant variety which consists of the Grand Rapids variety (V1), the Green Coral variety (V2), and the Red Coral variety (V3). The data is analyzed using analysis of variance and if the results obtained are significantly different then a DMRT test will be carried out. The research results showed that the Green Coral lettuce variety was better than the Grand Rapids and Red Coral varieties. This is shown by the results with the highest and best values for the observation variables of number of leaves, plant fresh weight, and chlorophyll content. The nutritional interval which consists of an interval of 2, 4, and 6 hours gave results that were inversely proportional to the variety treatment, that is, they were not significantly different in all observed variables. Keywords: lettuce plants, plant varieties, nutritional interval, substrate hydroponics
IMPLEMENTASI SISTEM PENGGAJIAN KARYAWAN BERBASIS WEB PADA TOKO PERCETAKAN SINDORO
Authors: Suprapto Bambang , Wulandari Inka 
Published: January 2025

Perkembangan teknologi informasi dan komunikasi yang pesat telah mempermudah akses data dan informasi secara online. Teknologi informasi berbasis web kini dimanfaatkan di berbagai bidang, Toko Percetakan Sindoro, sebuah perusahaan di Pringsewu, Lampung, masih menggunakan metode manual dalam pengolahan data karyawan dan perhitungan gaji, yang menyebabkan proses menjadi lambat dan rentan terhadap kesalahan. Penelitian ini bertujuan mengembangkan sistem informasi penggajian karyawan berbasis web yang efisien dan akurat, meningkatkan aksesibilitas dan transparansi informasi penggajian, serta mengoptimalkan penggunaan sumber daya manusia. Metode pengumpulan data meliputi wawancara, observasi, dan studi pustaka, sementara metode pengembangan sistem menggunakan pendekatan Extreme Programming (XP). Implementasi sistem ini diharapkan dapat membantu memudahkan dalam perhitungan gaji di Toko Percetakan Sindoro dengan mempermudah proses penggajian, mempercepat pembuatan laporan, dan meningkatkan transparansi serta kepercayaan antara pengelola dan karyawan.
SISTEM INFORMASI WEBSITE PENDIDIKAN NON FORMAL PKBM ADAM KUBU RAYA
Authors: Anggraini Agersi Diah 
Published: January 2025

Di era digital seperti saat ini keberadaan sistem informasi berbasis website menjadi kebutuhan pendukung dalam layanan pendidikan. Namun di satuan pendidikan non formal PKBM ADAM pengelolaan data masih dilakukan secara manual. Penelitian ini bertujuan untuk memberikan solusi berupa implementasi sistem informasi berbasis website. Penelitian ini menggunakan metode Rapid Application Development (RAD). Sedangkan untuk bahasa pemrograman yang digunakan adalah Content Management System (CSM) Blog. Hasil implementasi menunjukkan bahwa website ini mampu menyediakan dan menampilkan fitur-fitur utama seperti pendaftaran peserta didik baru secara online, informasi program pendidikan, jadwal kegiatan, serta laporan hasil belajar. Sistem ini juga mendukung pengolahan data secara terpusat, sehingga memudahkan administrator dalam mengelola data peserta didik, pengajar, dan program. Dengan adanya sistem informasi berbasis website, PKBM ADAM dapat memberikan pelayanan yang lebih efektif, transparan, dan terjangkau.
Cultural transposition: Adapting an Appreciative Inquiry to support organisational change in a non-Western context
Authors: Sabra Nabil 
Published: January 2025

This doctoral research study employed an Appreciative Inquiry as a culturally adjusted method for enabling six university educators to develop critical thinking (ijtihad) in Yemeni graphic design education.[1] Emanating from a constructivist paradigm, the study recognised the role of sociocultural contexts in knowledge formation. The Appreciative Inquiry was divided into four stages (Discovery, Dream, Design, and Destiny) based on Cooperrider and Whitney’s (2005) model. The study utilised Virtual Communities of Practice (VCoP)[2] based on a traditional cultural construct known as Halakat Elm (حلقات علم, knowledge circles). These circles were shaped by three cultural principles: wa’adeuk fa’ajbuh (واذا دعاك فأجبه); Husn al-Dhann (حسن الظن); and sadakat al elm (صدقة العلم). Key themes were identified through a Reflexive Thematic Analysis (RTA). The outcomes demonstrated that an Appreciative Inquiry developed inside the culturally specific construct of the Halakat Elm can serve as an effective, culturally responsive approach for developing co-creative approaches to organisational and pedagogical reform.

[1] The project was granted ethics approval (21/129) on July 8, 2021.
[2] A Virtual Community of Practice (VCoP) operates online. Here, individuals engage in instruction-based learning or group discussions within a specific domain, forming social structures to facilitate knowledge sharing and creation (Wenger-Trayner, 2015).
Modeling Enterprise Risk Management Ecosystems Using Text Analytics
Authors: SAE-LIM Patipan 
Published: January 2025

Abstract
In recent years, a paradigm shift in risk management has altered in a holistic way, which we call Enterprise Risk Management (ERM). ERM solves the limitations of Traditional Risk Management (TRM). Although firms perceive several benefits of ERM, the successful implementation of ERM rests upon institutional and contingency factors. The ERM approach then seeks to integrate the core system and processes of the firm rather than acting through silo perspective. With this in mind, this research applies text mining techniques to analyze bibliometric data from SCOPUS to propose the suitable ERM ecosystem. This longitudinal study uses 725 reliable documents across 26 years. The descriptive analysis relating to the journal, citation, author, and article performance is displayed. Text co-occurrence analysis of author keywords represented by network mapping shows five ecosystems that significantly integrate with ERM: (1) three lines of defense (3LOD), (2) corporate governance, (3) ERM framework, (4) firm culture, and (5) value creation. Ultimately, the hidden insight from the bibliometric data shows the correlation between ERM and modern firm direction such as sustainability.