bluuebunny/crossref_metadata_2025_split huggingface dataset:
Administration as Democratic Trustee Representation
Authors: Jackson Katharine 
Published: January 2024

AbstractThe “folk” theory of democracy that typically justifies the administrative state cannot help but lead to a discourse of constraint. If agency action is only legitimate when it mechanically applies the will of the voters as transposed by Congress through statutes, then the norms guiding that action will inevitably restrain agency discretion. As a result, attempts to establish the democratic credentials of the administrative state ironically obstruct the application of collective power. But this “folk” theory of democracy is bad theory. It is empirically incredible and, alarmingly, facilitates dangerous populist politics. Political theory instead suggests that a theory of democratic representation not only better explains legislative outcomes, but also deprives demagogues and deregulatory partisans of the fictions that prop up their agendas. After a brief survey of representative theory, this article will demonstrate that a model of trustee representation adequately describes administration, reinforces its democratic credentials and constitutes a space for politics in shaping the regulations that govern us all.
Psychological factors in symptom severity and quality of life in Raynaud’s phenomenon
Authors: Irving Dulcie , Daniels Jo 
Published: January 2024

AbstractBackground:Despite emotional stress being recognised as a key trigger for Raynaud’s phenomenon episodes, research in the area is still in its infancy.Aims:This study investigated the role of psychological factors relating to symptom severity and quality of life, and differences between Raynaud’s types (primary and secondary) to further inform the development of intervention in this field.Method:A cross-sectional design was used. Two hundred and ten adults with Raynaud’s completed an online questionnaire measuring stress, anxiety, depression, anxiety sensitivity, beliefs about emotions, symptom severity and quality of life.Results:Primary and secondary Raynaud’s groups differed in anxiety (p < .004), symptom severity (p < .001) and quality of life (p < .001). Stepwise multiple regressions indicated anxiety and Raynaud’s type explained 23% variance in hand symptom severity (p < .001); anxiety, Raynaud’s type and anxiety sensitivity explained 29% variance in symptom severity (global impact, p < .001); depression, Raynaud’s type and anxiety sensitivity explained 32% variance in quality of life (p < .001).Conclusions:Results highlight the importance of psychological factors in Raynaud’s phenomenon, indicating possible targets for treatment. Interventions such as cognitive behavioural therapy, which target both physical and psychological wellbeing, bear some promise as an adjuvant therapy for this group.
A needs theory of governance: taking transaction cost theory back to humanistic economics and self-actualisation
Authors: Sacchetti Silvia , Tortia Ermanno 
Published: January 2024

AbstractIn this paper we seek to integrate human needs and self-actualisation into the design of organisational governance. We problematise the assumptions that guide established justifications for governance, thus providing an opportunity for this type of theoretical approach. Drawing on Maslow's human psychology, we consider the potentially regressive features of the prescriptions of transaction cost theory (TCT), particularly the new institutionalist approach, and suggest inclusiveness as a mode of coordination that firms may wish to pursue to enhance self-actualisation. The main value added of this contribution is to highlight the need to discern among modes of governance design, using criteria of welfare maximisation by enabling opportunities for self-actualisation within the firm, different from the TCT focus on internal efficiency.
Gangbe in Badagry, Nigeria: Ogu Women’s Performance Practice, Social Status, and Creative Agency
Authors: KUNNUJI JOSEPH 
Published: January 2024

AbstractBefore colonialism, Gbe women enjoyed a social status on par with men. However, there has been a shift in the postcolonial social structure of Gbe societies. Modern capitalism, which accompanied colonial structures, privileged men, eroding many woman-empowering practices. This article examines Ogu women’s marginality through an ethnographic study of gangbe (a musical genre exclusive to married Ogu women). I argue that the sources of Ogu women’s marginality are interlocking, involving oppression stemming from colonial structures and the values of contiguous Yorùbá people. I propose a collaborative intervention that upends typical power structures that privilege Western and Yorùbá ideation over Indigenous Ogu knowledge, values, and practices.
Gemeinsam an einem Strang ziehen
Authors: Kuhlmann Barbara , Müller Carolin 
Published: January 2024

Was ist zu diesem Thema bereits bekannt? Gelingende multiprofessionelle Zusammenarbeit kann nicht dem Zufall überlassen werden. Es braucht Strukturen, die für die Mitarbeitenden leitend sind. Wie wird eine neue Perspektive eingebracht? In der Klinik Nette-Gut für Forensische Psychiatrie sind Bezugspflegeperson und Bezugstherapeut_in gemeinsam für die Organisation und formale Steuerung des gesamten Behandlungsprozesses einer untergebrachten Person verantwortlich. Was sind die Auswirkungen für die Praxis? Es gibt weniger Schnittstellenprobleme. Patient_innen erleben, dass ihre Meinungen und Behandlungsoptionen immer gemeinsam diskutiert werden. Pflegende übernehmen Verantwortung, erleben weniger Reibungsverluste und haben Klarheit über Zuständigkeiten und Kommunikationswege.
A new blood DNA methylation signature for Koolen-de Vries syndrome: Classification of missense KANSL1 variants and comparison to fibroblast cells
Authors: Awamleh Zain , Choufani Sanaa , Wu Wendy , Rots Dmitrijs , Dingemans Alexander J. M. , Nadif Kasri Nael , Boronat Susana , Ibañez-Mico Salvador , Cuesta Herraiz Laura , Ferrer Irene , Martínez Carrascal Antonio , Pérez-Jurado Luis A. , Aznar Lain Gemma , Ortigoza-Escobar Juan Dario , de Vries Bert B. A. , Koolen David A. , Weksberg Rosanna 
Published: January 2024

AbstractPathogenic variants in KANSL1 and 17q21.31 microdeletions are causative of Koolen-de Vries syndrome (KdVS), a neurodevelopmental syndrome with characteristic facial dysmorphia. Our previous work has shown that syndromic conditions caused by pathogenic variants in epigenetic regulatory genes have identifiable patterns of DNA methylation (DNAm) change: DNAm signatures or episignatures. Given the role of KANSL1 in histone acetylation, we tested whether variants underlying KdVS are associated with a DNAm signature. We profiled whole-blood DNAm for 13 individuals with KANSL1 variants, four individuals with 17q21.31 microdeletions, and 21 typically developing individuals, using Illumina’s Infinium EPIC array. In this study, we identified a robust DNAm signature of 456 significant CpG sites in 8 individuals with KdVS, a pattern independently validated in an additional 7 individuals with KdVS. We also demonstrate the diagnostic utility of the signature and classify two KANSL1 VUS as well as four variants in individuals with atypical clinical presentation. Lastly, we investigated tissue-specific DNAm changes in fibroblast cells from individuals with KdVS. Collectively, our findings contribute to the understanding of the epigenetic landscape related to KdVS and aid in the diagnosis and classification of variants in this structurally complex genomic region.
Wilms tumour resulting from paternal transmission of a TRIM28 pathogenic variant—A first report
Authors: Whitworth James , Armstrong Ruth , Maher Eamonn R. 
Published: January 2024

AbstractWilms tumour (nephroblastoma) is a renal embryonal tumour that is frequently caused by constitutional variants in a small range of cancer predisposition genes. TRIM28 has recently been identified as one such gene. Previously, observational data strongly suggested a parent of origin effect, whereby Wilms tumour only occurred following maternal inheritance of a pathogenic genetic variant. However, here we report a child with bilateral Wilms tumour who had inherited a pathogenic TRIM28 variant from their father. This finding suggests that genetic counselling for paternally inherited pathogenic variants in TRIM28 should include discussion of a potential risk of Wilms tumour.
High-altitude glacier archives lost due to climate change-related melting
Authors: Huber C. J. , Eichler A. , Mattea E. , Brütsch S. , Jenk T. M. , Gabrieli J. , Barbante C. , Schwikowski M. 
Published: January 2024

AbstractGlobal warming has caused widespread surface lowering of mountain glaciers. By comparing two firn cores collected in 2018 and 2020 from Corbassière glacier in Switzerland, we demonstrate how vulnerable these precious archives of past environmental conditions have become. Within two years, the soluble impurity records were destroyed by melting. The glacier is now irrevocably lost as an archive for reconstructing major atmospheric aerosol components.
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
Authors: Board Nathan L. , Yuan Zhe , Wu Fengting , Moskovljevic Milica , Ravi Meghana , Sengupta Srona , Mun Sung Soo , Simonetti Francesco R. , Lai Jun , Tebas Pablo , Lynn Kenneth , Hoh Rebecca , Deeks Steven G. , Siliciano Janet D. , Montaner Luis J. , Siliciano Robert F. 
Published: January 2024

AbstractThe persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1) proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune responses and clear infected cells will probably be necessary to achieve reduction of the latent reservoir. In the present study, we report two single-chain diabodies (scDbs) that target the HIV-1 envelope protein (Env) and the human type III Fcγ receptor (CD16). We show that the scDbs promoted robust and HIV-1-specific natural killer (NK) cell activation and NK cell-mediated lysis of infected cells. Cocultures of CD4+ T cells from people with HIV-1 on antiretroviral therapy (ART) with autologous NK cells and the scDbs resulted in marked elimination of reservoir cells that was dependent on latency reversal. Treatment of human interleukin-15 transgenic NSG mice with one of the scDbs after ART initiation enhanced NK cell activity and reduced reservoir size. Thus, HIV-1-specific scDbs merit further evaluation as potential therapeutics for clearance of the latent reservoir.
The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A
Authors: Brito Querido Jailson , Sokabe Masaaki , Díaz-López Irene , Gordiyenko Yuliya , Fraser Christopher S. , Ramakrishnan V. 
Published: January 2024

AbstractEukaryotic translation initiation involves recruitment of the 43S pre-initiation complex to the 5′ end of mRNA by the cap-binding complex eIF4F, forming the 48S translation initiation complex (48S), which then scans along the mRNA until the start codon is recognized. We have previously shown that eIF4F binds near the mRNA exit channel of the 43S, leaving open the question of how mRNA secondary structure is removed as it enters the mRNA channel on the other side of the 40S subunit. Here we report the structure of a human 48S that shows that, in addition to the eIF4A that is part of eIF4F, there is a second eIF4A helicase bound at the mRNA entry site, which could unwind RNA secondary structures as they enter the 48S. The structure also reveals conserved interactions between eIF4F and the 43S, probaby explaining how eIF4F can promote mRNA recruitment in all eukaryotes.
Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination
Authors: Steinthorsdottir Valgerdur , Halldorsson Bjarni V. , Jonsson Hakon , Palsson Gunnar , Oddsson Asmundur , Westergaard David , Arnadottir Gudny A. , Stefansdottir Lilja , Banasik Karina , Esplin M. Sean , Hansen Thomas Folkmann , Brunak Søren , Nyegaard Mette , Ostrowski Sisse Rye , Pedersen Ole Birger Vesterager , Erikstrup Christian ,   DBDS genomics consortium, Thorleifsson Gudmar , Nadauld Lincoln D. , Haraldsson Asgeir , Steingrimsdottir Thora , Tryggvadottir Laufey , Jonsdottir Ingileif , Gudbjartsson Daniel F. , Hoffmann Eva R. , Sulem Patrick , Holm Hilma , Nielsen Henriette Svarre , Stefansson Kari 
Published: January 2024

AbstractTwo-thirds of all human conceptions are lost, in most cases before clinical detection. The lack of detailed understanding of the causes of pregnancy losses constrains focused counseling for future pregnancies. We have previously shown that a missense variant in synaptonemal complex central element protein 2 (SYCE2), in a key residue for the assembly of the synaptonemal complex backbone, associates with recombination traits. Here we show that it also increases risk of pregnancy loss in a genome-wide association analysis on 114,761 women with reported pregnancy loss. We further show that the variant associates with more random placement of crossovers and lower recombination rate in longer chromosomes but higher in the shorter ones. These results support the hypothesis that some pregnancy losses are due to failures in recombination. They further demonstrate that variants with a substantial effect on the quality of recombination can be maintained in the population.
Molecular mechanisms underlying phenotypic degeneration in Cordyceps militaris: insights from transcriptome reanalysis and osmotic stress studies
Authors: Hoang Chinh Q. , Duong Giang H. T. , Tran Mai H. , Vu Tao X. , Tran Tram B. , Pham Hang T. N. 
Published: January 2024

AbstractPhenotypic degeneration in Cordyceps militaris poses a significant concern for producers, yet the mechanisms underlying this phenomenon remain elusive. To address this concern, we isolated two strains that differ in their abilities to form fruiting bodies. Our observations revealed that the degenerated strain lost the capacity to develop fruiting bodies, exhibited limited radial expansion, increased spore density, and elevated intracellular glycerol levels. Transcriptome reanalysis uncovered dysregulation of genes involved in the MAPK signaling pathway in the degenerate strain. Our RT-qPCR results demonstrated reduced expression of sexual development genes, along with upregulation of genes involved in asexual sporulation, glycerol synthesis, and MAPK regulation, when compared to the wild-type strain. Additionally, we discovered that osmotic stress reduced radial growth but increased conidia sporulation and glycerol accumulation in all strains. Furthermore, hyperosmotic stress inhibited fruiting body formation in all neutralized strains. These findings indicate dysregulation of the MAPK signaling pathway, the possibility of the activation of the high-osmolarity glycerol and spore formation modules, as well as the downregulation of the pheromone response and filamentous growth cascades in the degenerate strain. Overall, our study sheds light on the mechanisms underlying Cordyceps militaris degeneration and identifies potential targets for improving cultivation practices.
Systems biology approaches to identify driver genes and drug combinations for treating COVID-19
Authors: Ebrahimi Ali , Roshani Farinaz 
Published: January 2024

AbstractCorona virus 19 (Covid-19) has caused many problems in public health, economic, and even cultural and social fields since the beginning of the epidemic. However, in order to provide therapeutic solutions, many researches have been conducted and various omics data have been published. But there is still no early diagnosis method and comprehensive treatment solution. In this manuscript, by collecting important genes related to COVID-19 and using centrality and controllability analysis in PPI networks and signaling pathways related to the disease; hub and driver genes have been identified in the formation and progression of the disease. Next, by analyzing the expression data, the obtained genes have been evaluated. The results show that in addition to the significant difference in the expression of most of these genes, their expression correlation pattern is also different in the two groups of COVID-19 and control. Finally, based on the drug-gene interaction, drugs affecting the identified genes are presented in the form of a bipartite graph, which can be used as the potential drug combinations.
Insights into the prediction of the liquid density of refrigerant systems by artificial intelligent approaches
Authors: Li Huaguang , Baghban Alireza 
Published: January 2024

AbstractThis study presents a novel model for accurately estimating the densities of 48 refrigerant systems, categorized into five groups: Hydrofluoroethers (HFEs), Hydrochlorofluorocarbons (HCFCs), Perfluoroalkylalkanes (PFAAs), Hydrofluorocarbons (HFCs), and Perfluoroalkanes (PFAs). Input variables, including pressure, temperature, molecular weight, and structural groups, were systematically considered. The study explores the efficacy of both the multilayer perceptron artificial neural network (MLP-ANN) and adaptive neuro-fuzzy inference system (ANFIS) methodologies in constructing a precise model. Utilizing a comprehensive dataset of 3825 liquid density measurements and outlier analysis, the models achieved R2 and MSE values of 0.975 & 0.5575 and 0.967 & 0.7337 for MLP-ANN and ANFIS, respectively, highlighting their remarkable predictive performance. In conclusion, the ANFIS model is proposed as an effective tool for estimating refrigerant system densities, particularly advantageous in scenarios where experimental measurements are resource-intensive or sophisticated analysis is required.
The influence of hindered rotation on electron transfer and exchange interaction in triarylamine-triptycene-perylene diimide triads
Authors: Roger Chantal , Schmiedel Alexander , Holzapfel Marco , Lukzen Nikita N. , Steiner Ulrich E. , Lambert Christoph 
Published: January 2024

Intramolecular rotations modulate exchange interaction (J) as well as electronic couplings through variable π-overlap, affecting the rate constants of photoinduced charge separation and recombination in electron-donor-bridge-acceptor triads.
A coordinated green hydrogen and blue hydrogen trading strategy between virtual hydrogen plant and electro‐hydrogen energy system
Authors: Li Zhiwei , Zhao Yuze , Wu Pei 
Published: January 2024

AbstractIn the hydrogen‐based integrated energy system (HIES), there exists a hydrogen trading market where hydrogen producers and consumers are distinct stakeholders. Current research in hydrogen trading predominantly focuses on high‐cost green hydrogen (GH), which is not aligned with the current trend of utilizing hydrogen from multiple sources. To address this, this paper proposes a hydrogen trading strategy between the virtual hydrogen plant (VHP) and electro‐hydrogen energy system (EHES) based on a bi‐level model, considering the synergy of GH produced from electrolyzers and blue hydrogen (BH) derived from natural gas in the HIES. In the VHP level, the objective is to maximize profit from hydrogen sales, allowing for the determination of hydrogen prices. In the EHES level, the goal is to minimize the cost of energy supply, leading to the formulation of GH and BH purchasing plans based on hydrogen prices. Additionally, this paper incorporates a risk‐averse model from the information gap decision theory (IGDT) to account for the impact of wind power output uncertainties in the VHP level. Subsequently, leveraging the Karush–Kuhn–Tucker (KKT) conditions of the EHES level, the bi‐level problem is transformed into a solvable single‐level mathematical program with equilibrium constraints (MPEC), with the non‐linear equilibrium constraints linearized. The proposed bi‐level optimization model is validated through case studies encompassing industrial and residential hydrogen utilization within the HIES. The outcomes confirm the rationality of the proposed model, demonstrating that, in comparison to exclusively trading GH, the coordinated GH and BH trading can increase the profit of the VHP by 2.7% and reduce the costs of the EHES by 8.5%.
TransientX: A high-performance single-pulse search package
Authors: Men Yunpeng , Barr Ewan 
Published: January 2024

Context. Radio interferometers composed of a large array of small antennas possess large fields of view, coupled with high sensitivities. For example, the Karoo Array Telescope (MeerKAT) achieves a gain of up to 2.8 KJy−1 across its >1 deg2 field of view. This capability significantly enhances the survey speed for pulsars and fast transients. It also introduces challenges related to the high data rate, which reaches a few Tb s−1 for MeerKAT, and it requires substantial computing power.
Aims. To handle the high data rate of surveys, we have developed a high-performance single-pulse search software called “TransientX”. This software integrates multiple processes into one pipeline, which includes radio-frequency interference mitigation, dedispersion, matched filtering, clustering, and candidate plotting.
Methods. In TRANSIENTX, we developed an efficient CPU-based dedispersion implementation using the sub-band dedispersion algorithm. Additionally, TRANSIENTX employs the density-based spatial clustering of applications with noise (DBSCAN) algorithm to eliminate duplicate candidates, using an efficient implementation based on the kd-tree data structure. We also calculate the decrease of signal-to-noise ratio (s/N) resulting from dispersion measure, boxcar width, spectral index, and pulse-shape mismatches. Remarkably, we find that the decrease of S/N resulting from the mismatch between a boxcar-shaped template and a Gaussian-shaped pulse with scattering remains relatively small, at approximately 9%, even when the scattering timescale is ten times that of the pulse width. Additionally, the decrease in the S/N resulting from the spectral index mismatch becomes significant with multi-octave receivers.
Results. We have benchmarked the individual processes, including dedispersion, matched filtering, and clustering. Our dedispersion implementation can be executed in real time using a single CPU core on data with 4096 dispersion measure trials, which consist of 4096 channels and have a time resolution of 153 µs. Overall, TRANSIENTX offers the capability for efficient CPU-only real-time single-pulse searching.