bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing Irregular Migration from China
Authors: Chin James K. 
Published: September 2003

AbstractWith the development of China's economy since 1979, a new type of Chinese migration has emerged, which is more diversified and quite distinct from previous migration patterns. Trafficking in human beings and other forms of irregular migration are one of the most pressing and complex human rights issues today, reaching across borders and affecting most of the countries in the world, with new and serious security implications. As part of the international irregular migration flows toward and into the European Union (EU), the Chinese, particularly from Fujian and Zhejiang provinces, have played a major role since the 1980s. To some extent, it could be said that China provides the largest number of East Asian irregular immigrants to Europe.Based on fieldwork conducted in southern China over the past seven years, this paper proposes to examine current Chinese irregular migration trends. It will further present the Government's response regarding the migratory modus operandi and policy implications with the aim of offering policy makers an empirical insight into the most active region of emigration in China. Because of the difficulty and sensitivity involved in collecting data on the topic, materials in this paper are mainly based on a content analysis of local Chinese newspapers and my interviews with various people involved in irregular migration activities, such as “snakeheads”, illegal migrants and their family members, and police, local, and government officials at different levels.
Migration of Highly Skilled Chinese to Europe: Trends and Perspective
Authors: Zhang Guochu 
Published: September 2003

AbstractSince China's economic opening and reforms in 1978, the country has broadened and deepened its exchanges and relations with other countries. This has contributed to the increase in the scale of international migration of highly skilled Chinese abroad. The impact of the migration of highly skilled Chinese on China and the relevant nations particularly deserve attention and study. Following the earlier migration flows mainly to the United States, Japan, Canada, Australia, and New Zealand, the migration of highly skilled Chinese to Europe has become a notable new trend.Currently, the flow of international migration of highly skilled Chinese personnel is mainly oriented toward Europe and the United States. While studying abroad has been the main form of migration of the skilled, this has now been joined by the migration of technical and professional staff, and the trend is increasing. The main country of destination for Chinese students is the United States, which absorbs more than half of the total, while Australia and Canada receive the largest number of skilled Chinese manpower. The United States also receives a large number of Chinese technical personnel, but its proportion has declined, while the flow to Europe has sharply increased.This development may be attributed to the global expansion of economic, scientific and technological, as well as cultural and educational exchanges and cooperation. But it is also the result of an increase in the educational investment made by the Chinese people following the continuous increase in China's economic strength and the population's personal income. Of greater importance are the gaps between China and Europe at the scientific, technological, and educational levels and the research and marketing environment. The intervening changes in labour market and immigration policies in European and American countries accelerate the trend further. For all of these and other reasons, the spatial distribution of Chinese students will become more balanced and play a positive role in the promotion of mutually beneficial exchanges between China and other countries.
The New Chinese Migrants in France
Authors: Guerassimoff Carine 
Published: September 2003

AbstractLike the United Kingdom and the Netherlands, France is one of the major centres of Chinese migration in Europe. Chinese sojourners arrived in France at the beginning of the twentieth century and the 1911 census showed the presence of 238 Chinese in the country. From 1900 to World War I, this little community remained heterogeneous in its socio‐economic and professional composition (Archaimbault, 1952). Changes in this community occurred during World War I when the lack of labourers led the French Government to recruit 140,000 Chinese workers (Wou, 1939). The 2,000 to 4,000 Chinese who remained in France after the war constituted the basis of a Chinese community in France. In the 1920s, they were joined by some 2,000 student labourers (Wang, 2001; Bailey, 1988). From the 1920s to the 1940s, Zhejiang immigration in France rose until World War II and the rise of the communist party in China stopped the movement. Yet, Chinese immigration did not cease. Migrants of Chinese origin arrived essentially from the old French Indochina (Viet Nam‐Laos‐Cambodia) (Le, 1995). Immigration from these countries increased in the 1970s when different conflicts occurred. From the late 1970s to the early 1980s, France also saw the arrival, albeit in smaller numbers, of Chinese from Hong Kong and Taiwan, family members of citizens of the People's Republic of China (PRC). The new wave of Chinese migration from PRC started in the mid‐1980s and grew steadily until now, with some peaks, e.g. in the mid‐1990s.Recent fieldwork in France approached this community, in particular, those living in France with a precarious administrative status (asylum seekers or clandestine migrants). In general, the situation of the population covered by this fieldwork was still precarious. Although the paper does not include other categories such as students, entrepreneurs, or researchers, it is nevertheless possible to gather some details on the basis of French official data and reports. The following sections deal with the growing Chinese presence in France, and their precarious status. Most recent research tends to show a diversified Chinese migrant population profile; it also shows that they are still primarily active in the French ethnic Chinese market. In the initial stages of migration, the Chinese migrants continue to maintain links with China and sometimes with Chinese communities in Europe.
New Chinese Migration to Germany: Historical Consistencies and New Patterns of Diversification within a Globalized Migration Regime
Authors: Giese Karsten 
Published: September 2003

AbstractChinese migration to Germany is not very well documented, even though sojourners arrived in this country as early as the first half of the eighteenth century. There is some research on particular issues in specific historical contexts, such as the discrimination and persecution during the Third Reich (Yü‐Dembski, 1996, 1997), Chinese students in Germany between 1860 and 1945 (Harnisch, 1999), Chinese‐German mixed marriages (Groeling‐Che, 1991), and irregular immigration and human trafficking during the 1980s and 1990s (Giese, 1999a). Yet, no systematic research on the history of Chinese migration or continuous analysis of more recent migration trends and related political issues has been carried out so far. Some of the reasons for this include: Chinese communities have always formed only a small minority among the non‐German population; after World War II, Chinese communities were dispersed over the whole of (West) Germany and they have not created any visible “Chinatown” yet; and, until very recently, there seemed to be virtually no political or social problems related to Chinese migrants, and the few emerging political issues still appear insignificant compared to those related to other ethnic groups. As a result, Chinese immigration and the lives of Chinese migrants — widely ignored as a potential research topic for Modern China Studies in Germany — have not yet received attention from scholars of social sciences.This article will attempt to offer a comprehensive summary of the history of new Chinese migration to Germany from the early 1970s to the end of the second millennium. Mainly based on official statistics, it will then discuss recent trends in Chinese immigration for different groups of migrants since the 1990s, focusing on policy‐related issues and political implications of these recent and potential future developments.
New Chinese Migrants in Italy
Authors: Ceccagno Antonella 
Published: September 2003

AbstractItaly joined the group of European nations with a positive migratory balance in 1980, but now the presence of an immigrant workforce is definitely embedded in the Italian development model. The shift from a net emigration to net immigration country occurred when the internal migration from southern Italy, which had provided the factories in northern Italy with the necessary manpower for their economic development, was coming to an end, and productive decentralization was beginning with the re‐emergence of small businesses. Twenty years later, small dynamic businesses that are mainly clustered in industrial districts specializing in local production are a distinctive feature of the Italian economy to the extent that among industrialized countries Italy counts the largest number of small businesses and the lowest number of employees per business (Accornero, 2000). Starting from the 1980s, opportunities for a low‐skilled labour force opened for new migrants mainly in these productive activities. In addition, throughout the 1980s and the 1990s niche opportunities for self‐employment in workshops producing for Italian suppliers were also appearing or expanding.Among other migrant groups arriving in Italy were those of Chinese origin. The crucial time for the recent migration flow from China to Italy — either directly or via other European countries, such as France and Holland — can be dated from the early 1980s. Since then, a succession of unskilled workers originating almost exclusively from the south‐eastern Chinese province of Zhejiang arrived in the country, after the family‐based chains of emigration that had almost come to a halt during the years of the Cultural Revolution had again been revitalized.The number of immigrants of Chinese origin has grown rapidly over the last 20 years, as has the number of businesses owned by the Chinese. By today, the Chinese migrant community shows the strongest entrepreneurial aptitude, and, according to recent national data, account for the largest number of small business owners among non‐European Union (EU) immigrants in Italy.Unlike the situation in most of the western European countries, such as Great Britain and the Netherlands, where the Chinese are active mainly in the catering service, in Italy their main areas of activity are the production of ready‐to‐wear garments, leather garments and bags, and woollen sweaters. Until recently, these seemed to be the only productive sectors open to Chinese immigrants. However, new trends are emerging in the employment patterns of the Chinese in Italy. The two most striking new features are the expansion from performing only simple manufacturing tasks for Italian suppliers to actually managing the entire productive process in the garment sector, and the growing employment in Italian firms, especially in the dynamic industrial districts where migrants of other origins were already working in large numbers.
The Chinese in Spain
Authors: Nieto Gladys 
Published: September 2003

AbstractDuring the past 15 years, the Chinese migrant community in Spain has grown significantly. Originally a small and dispersed population, it now ranks fourth among the migrant groups from non‐European Union (EU) countries. Its increasing presence in daily urban life is evident everywhere. Even though the Chinese community has a long history of settlement in Spain, the Spanish population still considers the Chinese as a closed and somewhat mysterious community. References to exaggerated stereotypes and prejudices regarding their activities and social organization can often be overheard in daily conversations. However, China, usually considered exotic and remote, has recently assumed greater importance in Spain's foreign policy. Thus, the Spanish Government has drawn up the Asia‐Pacific Framework Plan for 2000–2002 as part of its international policy considerations, thereby extending its interests to include areas well beyond its traditional foreign policy focus on Latin America. The Government's objectives are to expand its economic relations with Asia, to enhance trade and tourism with the area, expand the development cooperation with China, the Philippines, and Viet Nam — countries defined as top priorities for the Spanish Government — and to reinforce linguistic and cultural ties with these countries (Bejarano, 2002). In support of the Asia‐Pacific Framework Plan, the Casa Asia (House of Asia) was established in Barcelona in 2002, an institution created to organize academic and artistic activities in order to promote the knowledge of the region among Spaniards, and to foster political, economic, and cultural relations with Asia.The Government intends to pursue two important objectives related to the increasing commitments it is seeking to establish with China, and which are also of relevance to the overseas Chinese as the principal social actors involved. First, the strengthening of commercial exchanges with the People's Republic of China (PRC) are likely to benefit import‐export activities among the Chinese migrants, and be supported by their knowledge and practical experience of the respective social environments. Second, the dissemination of information on Spain is expected to establish and maintain stronger links in both directions. In the near future, these initiatives may also be instrumental in increasing the movement of people between China and Spain. Besides these primary objectives, the initiative pursues another important aim — the promotion of the social integration of the Chinese migrant community in the country.This paper addresses these issues, including data sources and their availability on Chinese migrants in Spain, the relevant local legal framework and how it influences the development of the Chinese migrant group, its sociodemographic composition, and migratory patterns. Finally, it addresses the changes in their economic activities.
Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion
Authors: Schäfer Andreas , Schulz Christian , Eigenthaler Martin , Fraccarollo Daniela , Kobsar Anna , Gawaz Meinrad , Ertl Georg , Walter Ulrich , Bauersachs Johann 
Published: September 2003

Abstract
Chemokines released by the endothelium have proaggregatory properties on platelets. Fractalkine, a recently discovered membrane-bound chemokine with a transmembrane domain, is expressed in vascular injury; however, the effects of fractalkine on platelets have not yet been investigated. Blood was taken from healthy Wistar-Kyoto rats and the expression of the fractalkine receptor on platelets was demonstrated. The modulation of surface expression of P-selectin was assessed by flow cytometry. P-selectin expression was significantly enhanced by in vitro stimulation with recombinant rat fractalkine compared with baseline levels. Selectively inhibiting the function of recombinant fractalkine by an antagonizing antibody or the disruption of the G-protein–coupled intracellular signaling cascade of the fractalkine receptor by pertussis toxin (PTX) completely prevented fractalkine-mediated platelet activation. Preincubation with apyrase significantly attenuated the fractalkine-induced degranulation. In a flow chamber model of platelet adhesion, stimulation with fractalkine significantly enhanced platelet adhesion to collagen and fibrinogen. Similar to P-selectin expression, enhanced adhesion could be prevented by the antagonizing antibody or preincubation of platelets with PTX. Fractalkine, which is overexpressed in atherosclerosis and vascular injury, contributes to platelet activation and adhesion and hence is likely to play a pathophysiologically important role for increased thrombogenesis in vascular diseases.
Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma
Authors: Wang Eunice S. , Wu Kaida , Chin Allison C. , Chen-Kiang Selina , Pongracz Krisztina , Gryaznov Sergei , Moore Malcolm A. S. 
Published: September 2003

Abstract
The effects of telomerase inhibition with an oligonucleotide N3′ → P5′ thiophosphoramidate (GRN163) complementary to the telomerase template region were examined on human multiple myeloma (MM) and non-Hodgkin lymphoma (NHL) cell lines, primary MM cells, and tumor xenografts. GRN163 treatment reduced telomerase levels in all cells and induced more rapid telomeric shortening. Continuous GRN163 treatment for 7 to 14 days resulted in proliferative arrest, morphologic changes, and apoptosis characteristic of cell crisis in tumor cell lines with short (1.7-5.4 kb) but not long (9-11 kb) telomeres. Intratumoral administration of GRN163 also inhibited the growth of MM and NHL xenografts established from cell lines with short telomeres (Hs602 lymphoma, 2.7 kb; CAG myeloma, 2.7 kb) and increased tumor apoptosis. However, GRN163 therapy of NHL xenografts established from cells with long telomeres (11.0 kb) had equivocal effects on tumor growth and did not induce apoptosis during this time frame. Systemic daily intraperitoneal administration of GRN163 in myeloma xenografts with short telomere lengths also decreased tumor telomerase levels and reduced tumor volumes. These data demonstrate that telomerase is important for the replication of mature B-cell neoplasia by stabilizing short telomeres, and they suggest that telomerase inhibition represents a novel therapeutic approach to MM and NHL.
Transcriptional coactivation of c-Jun by the KSHV-encoded LANA
Authors: An Jiabin , Sun Yiping , Rettig Matthew B. 
Published: September 2003

Abstract
The Kaposi sarcoma–associated herpesvirus (KSHV)–encoded latency-associated nuclear antigen (LANA) modulates viral and cellular gene expression, including interleukin 6 (IL-6), a growth factor for KSHV-associated diseases. LANA-driven IL-6 expression is dependent on the activator protein 1 (AP1) response element (RE) within the IL-6 promoter. We show that LANA activates the AP1 RE in a Jun-dependent fashion and that LANA enhances the transcriptional activity of a GAL4-Jun fusion protein. Coimmunoprecipitation studies documented a physical interaction between LANA and c-Jun in transiently transfected 293 cells as well as the KSHV-infected BCBL-1 primary effusion lymphoma (PEL) cell line. Taken together, these data indicate that LANA is a transcriptional coactivator of c-Jun. In addition, electrophoretic mobility shift assays demonstrated that LANA induces binding of a c-Jun-Fos heterodimer to the AP1 RE, but does not itself bind to the AP1 RE. RNA interference experiments confirmed that LANA activates the AP1 RE, stimulates binding of a c-Jun-Fos heterodimer to the AP1 RE, and induces expression of IL-6. These data indicate that LANA is a transcriptional coactivator of c-Jun, a function that may have implications for the pathogenesis of KSHV-associated diseases.
Telehematology: critical determinants for successful implementation
Authors: Luethi Urs , Risch Lorenz , Korte Wolfgang , Bader Margrit , Huber Andreas R. 
Published: September 2003

Abstract
Despite modern technologies, such as immunophenotyping and molecular probing, cytomorphologic examination of stained peripheral blood smears by microscopy remains the mainstay of diagnosis in a large variety of diseases. This holds true especially in underdeveloped or rural areas where profound expertise and equipment are not easily available. Although communication technologies have been dramatically improved, telehematology has not become routine. To date, little information is available on which procedures are critical for successful implementation. Therefore, a study evaluating possible factors that prevented implementation of telehematology was initiated. We found that staining technique, smearing procedure, training skills, number of captured images, and prevalent disease influenced the accuracy of diagnosis by the reference laboratory. Using realtime teleconferencing allowed for overcoming these deficits. Together, when certain rules are observed, telehematology allows for rapid, accurate, standardized, and cheap expert advice. This technology should improve treatment of patients in remote areas where expertise is not available.
Fluorescence Probe Method for Investigating Polymer Structures in Nanometer Dimensions
Authors: Ito Shinzaburo , Aoki Hiroyuki 
Published: September 2003

Abstract
The applications of the optical methods using fluorescent probes for investigating polymer structure and dynamics at a molecular level are reviewed. The versatile and particular abilities of the fluorescence method have been exemplified using ultrathin films made of polymer monolayers, which provided fine model systems designed with a nanometer precision. In the latter part of this article, the emerging research field of scanning near-field optical microscopy (SNOM) is introduced. This novel microscopic technique enabled us to carry out spectroscopic and time-resolved measurements with a lateral resolution of 100 nm, which is obviously beyond the diffraction limit of light. We applied SNOM to study various nanometer-scale structures of polymer assemblies, such as the two-dimensional phase separation structure, morphology of single polymer chains, and structural inhomogeneity of polymer networks. These results showed that the combination of the fluorescence method and SNOM technique will open a new field of research on polymeric materials by providing molecular information on the basis of real optical images on a nanometric scale.
Transient Thermal Expansion of a Protein in Solution after Photo-Excitation of the Chromophore: Deoxymyoglobin
Authors: Miyata Ryoji , Terazima Masahide 
Published: September 2003

Abstract
The energy releasing process from a photo-excited chromophore embedded in a protein structure to the surrounding protein matrix and to the solvent is studied for deoxymyoglobin by the acoustic peak delay method with the transient grating technique. The acoustic peak delay time is usually a good indicator of the solvent heating time by the nonradiative transition after the photoexcitation and should be a positive value. However, the peak delay after the photoexcitation of deoxymyoglobin was found to be −15 ps. The observed negative peak delay was interpreted in terms of interference between two acoustic waves: an acoustic wave due to the thermal expansion of the protein and a wave of the medium. A theoretical calculation suggests that most of the energy of the heme is first transferred to the protein part and subsequently dissipates into the solvent. During this energy-releasing process, the protein experiences the transient thermal expansion and it creates an acoustic wave.