bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the influence of Atlantic Multidecadal Variability and spring soil moisture on European summer heat waves
Authors: Mascolo Valeria , Le Priol Clément , D’Andrea Fabio , Bouchet Freddy 
Published: February 2025

Abstract
In this work, we study and compare the influence of the Atlantic Multidecadal Variability (AMV) and spring soil moisture in Southern Europe on the duration and intensity of European summer heat waves. We study heat waves with return times of a few years and also propose a new methodological approach, return time maps, that allows us to study rare heat waves with return times of 10 or 50 years. We use the outputs from three climate models, namely IPSL-CM6A-LR, EC-Earth3, and CNRM-CM6-1, in which North Atlantic sea surface temperatures are restored towards the observed AMV anomalies. The three models give consistent results, with the exception of EC-Earth simulating a much greater influence of soil moisture. Our main conclusion is that spring soil moisture in Southern Europe is a slow driver of greater importance than the AMV for European summer heat waves, both in terms of the extension of the region of influence and in terms of amplitude. While the influence of the AMV concentrates over the very south of Europe, around the Mediterranean Basin, spring soil moisture influence extends over large parts of Europe. As might be expected, a positive AMV phase or low soil moisture generally induces hotter and longer heat waves. For more extreme events, the influences of the AMV and soil moisture increase, according to regional patterns that seem to be the same as for typical heat waves. However, confirming this statement would require datasets with more extreme events.
Origin and Evolution of the Holocene Magmatic System at Sakurajima Volcano, Japan
Authors: Kuritani Takeshi , Nakagawa Mitsuhiro , Matsumoto Akiko , Nishihara Ayumu 
Published: February 2025

Abstract
Sakurajima volcano has developed since 26 ka through post-caldera magmatic activity at the Aira caldera (formed at 30 ka) and is one of the most active volcanoes in Japan. In this study, new petrological and geochemical analyses were conducted on proximal volcanic products to understand the origin and evolution of the magmatic system during the Holocene. The volcanic products have andesitic and dacitic compositions (58–69 wt % SiO2), and relatively older products (9–1.6 ka) and younger products (&lt;1.3 ka) are characterised by having lower and higher P2O5 contents, respectively (low- and high-P2O5 groups, respectively). The low-P2O5 group products had lower TiO2 and Y contents, higher 87Sr/86Sr, 206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb ratios, and lower 143Nd/144Nd ratios than the high-P2O5 group products. It is suggested that the low-P2O5 group magmas were produced by the partial melting of lower crustal materials, and the compositional variations primarily reflected the variation in the degree of melting, with some contribution from mixing with mafic magmas. In contrast, the high-P2O5 group magmas were produced by mixing mafic and felsic magmas in varying proportions. The mafic end-member magmas evolved from mantle-derived primitive magmas with some contribution from crustal assimilation. The felsic end-member magmas were produced by fractional crystallisation following the melting of lower crustal materials with higher melting degrees than those of the low-P2O5 group magmas. In summary, the geochemical evolution of Holocene magmatic activity at Sakurajima was essentially controlled by intermittent discharges of partial melts from the lower crustal source region with increasing melting degrees. The remnants of the voluminous Aira rhyolitic magmas from caldera-forming eruptions were not involved in the Holocene magmatic system. Lower crustal source materials that produced the Aira rhyolites were also not involved. The lower crustal melting region, which was the main source of Holocene magmatism at Sakurajima, may have already existed at ~100 ka, well before the caldera-forming eruption at 30 ka.
COP9 SIGNALOSOME SUBUNIT 5A facilitates POLYAMINE OXIDASE 5 degradation to regulate strawberry plant growth and fruit ripening
Authors: Huang Yun , Gao Jiahui , Ji Guiming , Li Wenjing , Wang Jiaxue , Wang Qinghua , Shen Yuanyue , Guo Jiaxuan , Gao Fan 
Published: February 2025

Abstract
Polyamines (PAs), such as putrescine, spermidine, and spermine, are essential for plant growth and development. However, the post-translational regulation of PA metabolism remains unknown. Here, we report the COP9 SIGNALOSOME SUBUNIT 5A (FvCSN5A) mediates the degradation of the POLYAMINE OXIDASE 5 (FvPAO5), which catalyzes the conversion of spermidine/spermine to produce H2O2 in strawberry (Fragaria vesca). FvCSN5A is localized in the cytoplasm and nucleus, is ubiquitously expressed in strawberry plants, and is rapidly induced during fruit ripening. FvCSN5A RNA interference (RNAi) transgenic strawberry lines exhibit pleiotropic effects on plant development, fertility, and fruit ripening due to altered PA and H2O2 homeostasis, similar to FvPAO5 transgenic overexpression lines. Moreover, FvCSN5A interacts with FvPAO5 in vitro and in vivo, and the ubiquitination and degradation of FvPAO5 are impaired in FvCSN5A RNAi lines. Additionally, FvCSN5A interacts with cullin 1 (FvCUL1), a core component of the E3 ubiquitin-protein ligase complex. Transient genetic analysis in cultivated strawberry (Fragaria × ananassa) fruits showed that inhibiting FaPAO5 expression could partially rescue the ripening phenotype of FaCSN5A RNAi fruits. Taken together, our results suggest that the CSN5A-CUL1-PAO5 signaling pathway responsible for PA and H2O2 homeostasis is crucial for strawberry vegetative and reproductive growth in particular fruit ripening. Our findings present a promising strategy for improving crop yield and quality.
The DNA methylation–demethylation balance prevents development of multiple megaspore mother cells in Arabidopsis
Authors: Jiang Ting , Li Lei , Hu Qianqian , Kuang Xianyu , Zhang Lei , Zeng Wenjie , Miki Daisuke , Zheng Binglian 
Published: February 2025

Abstract
Female gametophyte development initiates from the megaspore mother cell (MMC), and only 1 somatic cell develops into an MMC. Here, we report that the balance between DNA methylation and demethylation ensures the maintenance of a single MMC in Arabidopsis (Arabidopsis thaliana). Surprisingly, a decrease or an increase of all 3 DNA methylation types (mCG, mCHG, and mCHH) caused abnormal enlargement of MMC-like cells and re-balancing DNA methylation rescued the enlarged MMC-like cells in the mutants of regulators for DNA methylation and demethylation. Systematic quantification of DNA methylation at the single-cell level demonstrated that mCHH levels begin to decrease from the central precursor MMC, preceding expression of the MMC marker KNUCKLES(KNU). Disrupting the regulation of DNA methylation caused the mCHH levels to become similar in the MMC and its neighboring cells, and these neighbors usually developed into MMC-like cells. Levels of the de novo DNA methyltransferase DOMAINS REARRANGED METHYLTRANSFERASE2 (DRM2) in the precursor MMC decreased before KNU expression, but the levels of the DNA glycosylase DEMETER decreased after KNU expression. Re-introduction of DRM2 or knockdown of DEMETER specifically in neighboring cells rescued the defects in drm1 drm2 double mutants. Collectively, our findings demonstrate that the balance of DNA methylation, rather than total methylation levels, facilitates maintenance of a single MMC.
The Power of the Pen: Do Poets, Fiction Literature, and Culture Affect the Politics of (Education) Policy-Making?
Authors: Garritzmann Julian L 
Published: February 2025

Abstract
Culture is neglected or downplayed in the political economy and public policy literature in general and the politics of education literature in particular. An important recent book by Cathie Jo Martin—Education for All? Literature, Culture, and Education Development in Britain and Denmark—sets out to change this by studying the role of fiction literature and fiction writers in education policy-making in Britain and Denmark from 1700 until today. Education for all? highlights that and how fiction and fiction writers have played an important role in the politics of education and offers both quantitative text-analysis evidence and historical case studies to demonstrate the power of the pen. This article discusses Martin's crucial contribution, aiming to help contribute to develop a systematic research agenda on the role of culture in the politics of (education) policy. Among other things, the review develops a new typology of different kinds of cultural influences and sets out several avenues for future research.
Benefits of movement-based Behaviors on improving erectile function in American men: a nationwide survey study
Authors: Chen Yiming , Zhuang Qianfeng , Xia Wei , Shao Naiyuan , Zhang Bo , Feng Xingliang 
Published: February 2025

Abstract

Background
Erectile dysfunction (ED) is a prevalent condition with significant psychological and physiological impacts. Recently, a new concept called movement-based behaviors (MBB) has been proposed, which includes four types of PA: vigorous PA (VPA), moderate-intensity PA (MPA), walking/cycling, and muscle-strengthening activities (MSA), and uses an MBB index (range 0–4) to estimate the combined effects of these activities on health outcomes.

Aim
This study aims to evaluate the relationship between different types of physical activities (PA) and ED using the MBB index in a nationally representative sample of U.S. men.

Methods
We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2001-2004, including 3435 male participants. Multivariate logistic regressions were performed to explore the associations, supplemented with subgroup analysis and sensitivity analysis.

Outcomes
The assessment of PA in this study is based on four self-reported questions from the NHANES Mobile Examination Center interview, including VPA, MPA, walking/cycling, and MSA. The MBB index, ranging from 0 to 4, was used to assess combined PA types. ED was evaluated using a single-question self-assessment.

Results
Higher MBB index values were associated with lower ED risk. Participants with an MBB index of 2 had a significantly lower risk of ED in Model 3 (OR = 0.65, 95% CI: 0.43-0.97, P = 0.04). Those with an MBB index of 3 or 4 had the lowest risk of ED across all models, with OR_Model1 = 0.29 (95% CI: 0.21-0.40, P &lt; 0.0001), OR_Model2 = 0.52 (95% CI: 0.37-0.73, P &lt; 0.001), and OR_Model3 = 0.61 (95% CI: 0.41-0.90, P = 0.02). However, this relationship was not significant in subgroups with severe ED or comorbid conditions.

Clinical Implications
Our findings can provide clinicians with guidance to help patients personalize their selection of different exercise combinations.

Strengths and Limitations
We explored the impact of different exercise combinations on reducing ED risk and innovatively proposed the MBB index for a comprehensive assessment of exercise benefits, supported by a large sample size and multivariable adjustments. However, the limitations of cross-sectional design and recall bias cannot be overlooked.

Conclusion
The MBB index effectively demonstrates that combined PA can reduce ED risk, supporting tailored exercise recommendations for patients.
Exploring industry perspectives and preferences about calf handling and restraint methods used during spring processing of calves in western Canada
Authors: Arkangel Lindsey , Windeyer Claire , Goldhawk Christy , Adams Cindy , Pajor Ed 
Published: February 2025

Abstract
Calf processing events have important animal health, management, and sociocultural roles in the beef cattle industry. In western Canada, the three most commonly used methods for spring processing are roping and wrestling (RW), roping and Nord fork (NF), and tilt table (TT). The objective of this study was to understand the preferences and perceptions of handling event participants about calf handling and restraint methods commonly used during western Canadian beef calf processing events during the spring season. Data were collected using a mixed-methods online questionnaire. Quantitative analysis was used to describe the study participants and determine preference rankings. Qualitative, thematic analysis was used to explore participants’ perceptions about the common handling and restraint methods and to identify values within and across participants. The majority of participants were farm hands or staff members (92.8%), followed by owners (4.9%), family members (1.4%), friends (0.5%), and others (0.4%). The most preferred method to use was RW, and TT was the least preferred (χ2 = 3239.1, df = 6, p &lt; 0.001). Participants shared values regarding calf safety and stress, processing efficiency, convenience, human safety, and labour intensity when explaining their preference to use calf handling and restraint methods for spring processing. Responses highlighted the need for understanding and skill in low stress handling and processing tasks in order for any of the methods to be effective. These values identify aspects to address when developing best practice recommendations for calf handling and restraint. Furthermore, focusing communication through the lens of these shared values will likely positively engage participants in extension efforts and community discussions.
Bacteriophage therapy in women with chronic recurrent cystitis caused by multidrug-resistant bacteria: A prospective, observational, comparative study
Authors: Krakhotkin Denis , Iglovikov Nikolai , Blecher Gideon , Chernylovskyi Vladimir , Greco Francesco , Gayvoronskaya Svetlana A. , El Meliegy Amr 
Published: February 2025

Abstract

Objectives
The aim of this study was to evaluate the effects of the combination of bacteriophage therapy with antibiotics and bacteriophage treatment alone on relieving clinical symptoms of chronic recurrent cystitis caused by multidrug-resistant bacteria.

Materials and methods
This clinical trial compared the treatment methods of 217 female patients with chronic recurrent cystitis caused by multidrug-resistant bacteria, who were investigated from June 2020 to May 2023. Patients were allocated into 4 groups: group I: received bacteriophage (Sextaphage) therapy alone; group II: received a combination of bacteriophages (Sextaphage) and furazidin; group III: received a combination of bacteriophage (Sextaphage) and furazidin with cefixime; and group IV: received furazidin and cefixime (without bacteriophage). The primary outcome included changes in the acute cystitis symptom scale and the pain visual analog scale, which were completed on days 7 and 14 following treatment. Secondary outcome measures included bladder diary records of urinary symptoms, median voided volumes, level of bacteriuria, and degree of leukocyturia.

Results
Initially, 217 female patients were presented during baseline visits. Those who did not meet the criteria inclusions were excluded, and 178 female patients were included in the final analysis. Statistically significant improvements from baseline in acute cystitis symptom scale scores for differential, typical symptoms, and quality of life domains were observed after 14 days of treatment in groups II, III, and IV. The pain level measured on the 14th day with the visual analog scale significantly decreased in groups II, III, and IV compared with group I. The patients of group I had a reduction of mean level bacteriuria of Escherichia coli from 106 to 102 CFU/mL at 14 days of therapy. Significant improvement of voided volume from baseline was observed in groups II, III, and IV. Episodes of urinary frequency, both daytime and night-time, reduced significantly from baseline in all 4 groups only at 14 days of treatment.

Conclusions
Bacteriophage cocktail alone or with antibiotics may improve clinical symptoms in women with chronic recurrent cystitis caused by multidrug-resistant bacterial pathogens. In addition to improving clinical symptoms, the therapy with a phage cocktail may restore antibiotic sensitivity and increase the efficacy of antimicrobial agents.
Who is living near different types of US Superfund sites: A latent class analysis considering site contaminant profiles
Authors: Trottier Brittany A. , Olshan Andrew , Edwards Jessie K. , Engel Lawrence S. , Nichols Hazel B. , White Alexandra J. 
Published: February 2025

Background:
Millions of people in the United States live near Superfund sites and may be exposed to hazardous chemicals from those sites. However, there is limited research on chemicals present at sites and the demographics of nearby communities. We aimed to identify subgroups of Superfund sites with similar contaminant profiles and evaluate whether sociodemographic characteristics vary by type of site.

Methods:
We used US Environmental Protection Agency Superfund data to identify sites active in the year 2000. Census tract centroids located within 3 miles of every Superfund site were identified and a weighted average of census tract-level sociodemographics using the 2000 US Census was calculated. Superfund sites with similar contaminant profiles were identified using latent class analysis. We compared the median sociodemographic characteristics, overall and by contaminant latent class, with those of the overall 2000 US Census.

Results:
We identified seven latent classes based on 12 contaminant categories from 1332 Superfund sites active in 2000. Overall, there were few differences in sociodemographics observed by the presence of any Superfund site compared with the overall US Census. After stratifying by contaminant profile, we observed evidence of disparities for two classes of sites, defined by (1) high diversity of chemical exposure and lumber industry and (2) batteries and metals, which were more likely to have higher hazard scores and to be near communities with higher proportions of non-White individuals, lower socioeconomic status, and higher social vulnerability.

Conclusion:
Disadvantaged communities, with higher social vulnerability, were more likely to be near certain Superfund sites with higher hazard scores.
Burnout in modern-day health care: Where are we, and how can we markedly reduce it? A meta-narrative review from the EUREKA* project
Authors: Linzer Mark , O'Brien Emily C. , Sullivan Erin , Rathert Cheryl , Simmons Derick R. , Johnson Dawn H. , McKinney Warren T. , Mallick Sanjoyita , Porta Carolyn M. , Poplau Sara , Wambua Mike , Bosquet Alli , Farley Heather , Montori Victor M. , Goelz Elizabeth 
Published: February 2025

Background
Burnout is disrupting the health care workforce, threatening the livelihoods of health care workers and the probability of safe and effective patient care.

Purposes
The aims of this study were to describe the evolution and gaps in burnout research and identify next steps to advance the field and reduce burnout.

Methodology/Approach
We formed a learning community of burnout scholars and Chief Wellness Officers, sought recent review articles for a meta-narrative synthesis of themes on health care worker burnout, and conducted focus groups with learning community members.

Results
In 1,425 systematic burnout studies found in a Medline database search of systematic reviews published since 2018, 68 were retained for analysis. Many focused on individual interventions (e.g., mindfulness), paying inconsistent attention to (a) what comprises burnout, (b) prevalence and contributors, (c) theories underlying it, (d) presence in marginalized populations, and (e) innovative research methods. There was consensus that burnout poses a global crisis, but there was no agreement on how to address it. Focus group participants noted that although burnout research is now “mainstream,” health systems commit insufficient resources to addressing it. They proposed that emphasizing organizational finances and patient safety may make burnout a priority for health systems.

Practice Implications
Despite burnout's progressing unabated, many organizations do not employ known burnout indicators (worker dissatisfaction or turnover) as wellness metrics. Research into organizational contributors to burnout, rigorous evaluation of interventions, and organizational adoption of research findings into systemic action are urgently needed. A well-supported international research agenda is required to quickly move the field ahead and reduce or ultimately eliminate burnout.
Nasopharyngeal Carriage and Antibiotic Resistance in Children With Sickle Cell Disease: The DREPANOBACT French Multicenter Prospective Study
Authors: Pham Luu-Ly , Varon Emmanuelle , Bonacorsi Stéphane , Boubaya Marouane , Benhaim Patricia , Amor-Chelihi Lahoueri , Houlier Marine , Koehl Bérengère , Missud Florence , Brousse Valentine , Gajdos Vincent , Bizot Etienne , Briand Coralie , Malka Alexandra , Odièvre Marie-Hélène , Romain Anne-Sophie , Hau Isabelle , Pondarré Corinne , See Hélène , Guitton Corinne , Zenkhri Férielle , Holvoet Laurent , Benkerrou Malika , Da Silveira Charlène , Belaid Nabil , Laurent Odile , Vassal Mélanie , Basmaci Romain , Aupiais Camille , Bloch-Queyrat Coralie , Lévy Corinne , Cohen Robert , Ouldali Naïm , De Pontual Loïc , Carbonnelle Etienne , Gaschignard Jean 
Published: February 2025

Background:
Children with sickle cell disease (SCD) are susceptible to invasive bacterial infections, particularly those caused by Streptococcus pneumoniae. Data concerning nasopharyngeal carriage remain scarce in this population at high risk of resistant bacteria owing to antibiotic pressure and frequent hospitalizations.

Methods:
We conducted this prospective trial, DREPANOBACT, in 7 French hospitals to assess the nasopharyngeal carriage rate for S. pneumoniae among children with SCD aged 6 months–15 years between September 2022 and April 2024. The secondary aim was to determine the serotype distribution and proportion of penicillin nonsusceptible S. pneumoniae isolates and the carriage and antibiotic resistance rates for Staphylococcus aureus, Moraxella catarrhalis and Haemophilus influenzae.

Results:
In total, 300 children were enrolled [median age, 8 years (interquartile range: 4–12 years)]. S. pneumoniae carriage accounted for 32 cases (11%), including 21 penicillin nonsusceptible S. pneumoniae strains (66%). The main serotypes were 23A (n = 4), 35B (n = 4), 11A (n = 3) and 15C (n = 3). Overall, 75% of the serotypes were non-13-valent pneumococcal conjugate vaccine (PCV) serotypes, with 19% and 53% covered by PCV20 and PCV21, respectively. The carriage rates for S. aureus, M. catarrhalis and H. influenzae were 31%, 17% and 11%, respectively. Methicillin resistance was observed in 5% of S. aureus strains. Age ≤5 years was significantly associated with S. pneumoniae, M. catarrhalis, and H. influenzae carriage, while age ≥11 years was associated with S. aureus carriage.

Conclusions:
Surveillance of nasopharyngeal carriage in children with SCD is warranted to monitor changes in predominant serotypes and resistance patterns.