bluuebunny/crossref_metadata_2025_split huggingface dataset:
BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation
Authors: Musa Rachel E. , Lester Kaitlyn L. , Quickstad Gabrielle , Vardabasso Sara , Shumate Trevor V. , Salcido Ryan T. , Ge Kai , Shpargel Karl B. 
Published: December 2023

ABSTRACT
Cornelia de Lange syndrome (CdLS) is a congenital disorder featuring facial dysmorphism, postnatal growth deficits, cognitive disability and upper limb abnormalities. CdLS is genetically heterogeneous, with cases arising from mutation of BRD4, a bromodomain protein that binds and reads acetylated histones. In this study, we have modeled CdLS facial pathology through mouse neural crest cell (NCC)-specific mutation of BRD4 to characterize cellular and molecular function in craniofacial development. Mice with BRD4 NCC loss of function died at birth with severe facial hypoplasia, cleft palate, mid-facial clefting and exencephaly. Following migration, BRD4 mutant NCCs initiated RUNX2 expression for differentiation to osteoblast lineages but failed to induce downstream RUNX2 targets required for lineage commitment. BRD4 bound to active enhancers to regulate expression of osteogenic transcription factors and extracellular matrix components integral for bone formation. RUNX2 physically interacts with a C-terminal domain in the long isoform of BRD4 and can co-occupy osteogenic enhancers. This BRD4 association is required for RUNX2 recruitment and appropriate osteoblast differentiation. We conclude that BRD4 controls facial bone development through osteoblast enhancer regulation of the RUNX2 transcriptional program.
The Small Interactor of PKD2 protein promotes the assembly and ciliary entry of the Chlamydomonas PKD2–mastigoneme complexes
Authors: Das Poulomi , Mekonnen Betlehem , Alkhofash Rama , Ingle Abha V. , Workman E. Blair , Feather Alec , Zhang Gui , Chasen Nathan , Liu Peiwei , Lechtreck Karl F. 
Published: December 2023

ABSTRACT
In Chlamydomonas, the channel polycystin 2 (PKD2) is primarily present in the distal region of cilia, where it is attached to the axoneme and mastigonemes, extracellular polymers of MST1. In a smaller proximal ciliary region that lacks mastigonemes, PKD2 is more mobile. We show that the PKD2 regions are established early during ciliogenesis and increase proportionally in length as cilia elongate. In chimeric zygotes, tagged PKD2 rapidly entered the proximal region of PKD2-deficient cilia, whereas the assembly of the distal region was hindered, suggesting that axonemal binding of PKD2 requires de novo assembly of cilia. We identified the protein Small Interactor of PKD2 (SIP), a PKD2-related, single-pass transmembrane protein, as part of the PKD2–mastigoneme complex. In sip mutants, stability and proteolytic processing of PKD2 in the cell body were reduced and PKD2–mastigoneme complexes were absent from the cilia. Like the pkd2 and mst1 mutants, sip mutant cells swam with reduced velocity. Cilia of the pkd2 mutant beat with an increased frequency but were less efficient in moving the cells, suggesting a structural role for the PKD2–SIP–mastigoneme complex in increasing the effective surface of Chlamydomonas cilia.
Accuracy of artificial intelligence CT quantification in predicting COVID-19 subjects’ prognosis
Authors: Arian Arvin , Mehrabi Nejad Mohammad-Mehdi , Zoorpaikar Mostafa , Hasanzadeh Navid , Sotoudeh-Paima Saman , Kolahi Shahriar , Gity Masoumeh , Soltanian-Zadeh Hamid 
Published: December 2023

Background
Artificial intelligence (AI)-aided analysis of chest CT expedites the quantification of abnormalities and may facilitate the diagnosis and assessment of the prognosis of subjects with COVID-19.

Objectives
This study investigates the performance of an AI-aided quantification model in predicting the clinical outcomes of hospitalized subjects with COVID-19 and compares it with radiologists’ performance.

Subjects and methods
A total of 90 subjects with COVID-19 (men, n = 59 [65.6%]; age, 52.9±16.7 years) were recruited in this cross-sectional study. Quantification of the total and compromised lung parenchyma was performed by two expert radiologists using a volumetric image analysis software and compared against an AI-assisted package consisting of a modified U-Net model for segmenting COVID-19 lesions and an off-the-shelf U-Net model augmented with COVID-19 data for segmenting lung volume. The fraction of compromised lung parenchyma (%CL) was calculated. Based on clinical results, the subjects were divided into two categories: critical (n = 45) and noncritical (n = 45). All admission data were compared between the two groups.

Results
There was an excellent agreement between the radiologist-obtained and AI-assisted measurements (intraclass correlation coefficient = 0.88, P < 0.001). Both the AI-assisted and radiologist-obtained %CLs were significantly higher in the critical subjects (P = 0.009 and 0.02, respectively) than in the noncritical subjects. In the multivariate logistic regression analysis to distinguish the critical subjects, an AI-assisted %CL ≥35% (odds ratio [OR] = 17.0), oxygen saturation level of <88% (OR = 33.6), immunocompromised condition (OR = 8.1), and other comorbidities (OR = 15.2) independently remained as significant variables in the models. Our proposed model obtained an accuracy of 83.9%, a sensitivity of 79.1%, and a specificity of 88.6% in predicting critical outcomes.

Conclusions
AI-assisted measurements are similar to quantitative radiologist-obtained measurements in determining lung involvement in COVID-19 subjects.
Rural health care worker wellness during COVID-19: Compassion fatigue, compassion satisfaction & utilization of wellness resources
Authors: Bailey Bridget C. , Cox Stephanie , Terris Lisa , van Oppen Dorothy , Howsare Janie , Berry James H. , Winstanley Erin L. 
Published: December 2023

Objective
The goal of this study was to identify factors associated with compassion fatigue (CF) and compassion satisfaction (CS) among rural health care workers (HCWs) during the COVID-19 pandemic. The secondary purpose was to assess utilization of wellness resources and preferences for new resources.

Methods
A survey was distributed (October-December 2020) and completed by faculty, clinicians and staff (n = 406) at a rural university. Measures included a modified version of the Professional Quality of Life Scale (PROQOL-21), the Patient Health Questionnaire-4 and the Brief Resilience Coping Scale. Respondents reported their use of wellness resources and their preferences for new resources.

Results
The mean CF score was 21.1, the mean CS score was 26.8 and 42.0% screened positive for depression or anxiety. Few of the existing wellness resources were utilized and respondents’ preferences for new wellness resources included time off (70.7%), onsite food trucks (43.0%) and support animals (36.5%). Younger age, depression and anxiety were associated with higher CF. Older age, better mental health and resilience were associated with higher CS.

Conclusions
Rural HCWs have high CF, yet few utilize wellness resources. Rural health care organizations may foster wellness by providing time off for self-care, expanding mental health services and building resilience.
HBV prevalence in Sub-continental countries: A systematic review and meta-analysis
Authors: Hogan Sam , Page Andrew , Dixit Sameer , McBride Kate A. 
Published: December 2023

Background
Hepatitis B virus (HBV) is a major source of disease burden worldwide, with an estimated 296 million individuals living with infections worldwide. Although vaccine programs exist to control infections, certain sub-populations around the world continue to have very high prevalence of HBV infection.

Methods
A systematic search of studies of HBV published after 2010 was conducted for India, Pakistan, Bangladesh, Nepal, Sri Lanka and Bhutan. Each paper was independently screened for risk of bias and inclusion. Data were extracted from included studies before being analysed to estimate pooled prevalence, and to conduct sub-group analyses. Random-effects models were used for estimating summary prevalence due to a high level of heterogeneity between studies, and funnel plots were combined with Egger’s test to assess publication bias. Meta-regression was conducted to investigate sources of between-study heterogeneity.

Results
The pooled prevalence of HBV across all studies was 3% (95% CI 0.02, 0.05). For countries with multiple studies, the pooled prevalence in India was 3% (95% CI 0.02, 0.04), in Pakistan 6% (95% CI 0.03, 0.09), in Bangladesh 5% (95% CI of 0.02, 0.12), and in Nepal 1% (95% CI 0.00, 0.08). There was some evidence of publication bias, and a high level of heterogeneity across studies. Risk of bias analysis found most studies to be of fair or moderate quality.

Conclusions
The prevalence of HBV among countries in the sub-continent was higher than the global average, but was not as high as some other regions. Countries with greater numbers of displaced persons had higher prevalence of HBV, with a wide range of prevalence between subpopulations likely reflecting differential uptake, and implementation, of vaccination programs.
How Do We Look? Resisting Visual Biopolitics, Fatimah Tobing Rony (2022)
Authors: Byabartta Debarati 
Published: December 2023

Review of: How Do We Look? Resisting Visual Biopolitics, Fatimah Tobing Rony (2022)
Durham: Duke University Press, 248 pp.,
ISBN 978-1-47801-460-7, p/bk, $26.95
ISBN 978-1-47801-367-9, h/bk, $102.95
ISBN 978-1-47802-190-2, e-book, $26.95
Ensuring quality in 17OHP mass spectrometry measurement: an international study assessing isomeric steroid interference
Authors: Ho Chung Shun , Hoad Kirsten , Cooke Brian R. , Andersen Trisha , Graham Peter , van den Berg Sjoerd A.A. , Hartmann Michaela F. , Lo Clara W.S. , Loh Tze Ping , de Rijke Yolanda B. , van Zelst Bertrand D. , Wudy Stefan A. , Zakaria Rosita , Greaves Ronda F. 
Published: December 2023

Abstract

Objectives
Interference from isomeric steroids is a potential cause of disparity between mass spectrometry-based 17-hydroxyprogesterone (17OHP) results. We aimed to assess the proficiency of mass spectrometry laboratories to report 17OHP in the presence of known isomeric steroids.

Methods
A series of five samples were prepared using a previously demonstrated commutable approach. These samples included a control (spiked to 15.0 nmol/L 17OHP) and four challenge samples further enriched with equimolar concentrations of 17OHP isomers (11α-hydroxyprogesterone, 11β-hydroxyprogesterone, 16α-hydroxyprogesterone or 21-hydroxyprogesterone). These samples were distributed to 38 participating laboratories that reported serum 17OHP results using mass spectrometry in two external quality assurance programs. The result for each challenge sample was compared to the control sample submitted by each participant.

Results
Twenty-six laboratories (68 % of distribution) across three continents returned results. Twenty-five laboratories used liquid chromatography-tandem mass spectrometry (LC-MS/MS), and one used gas chromatography-tandem mass spectrometry to measure 17OHP. The all-method median of the control sample was 14.3 nmol/L, ranging from 12.4 to 17.6 nmol/L. One laboratory had results that approached the lower limit of tolerance (minus 17.7 % of the control sample), suggesting the isomeric steroid caused an irregular result.

Conclusions
Most participating laboratories demonstrated their ability to reliably measure 17OHP in the presence of the four clinically relevant isomeric steroids. The performance of the 12 (32 %) laboratories that did not engage in this activity remains unclear. We recommend that all laboratories offering LC-MS/MS analysis of 17OHP in serum, plasma, or dried bloodspots determine that the isomeric steroids are appropriately separated.
Query optimization-oriented lateral expansion method of distributed geological borehole database
Authors: Luo Qingjia 
Published: December 2023

Abstract
In order to reduce the resource occupancy and retrieval efficiency of geological drilling databases, this study proposes a distributed horizontal expansion method for query optimization of geological drilling databases by constructing a comprehensive geological data subtree, analyzing the characteristics of distributed databases and elements in geological databases, and quickly retrieving data resources based on element attributes. In addition, this study has designed a method to horizontally extend the database designed for drilling holes using a multi-constraint model in order to achieve extension optimization of the distributed geological drilling database. Experiments are conducted to verify the performance and applicability of the proposed method. The experiment shows that when the geological data capacity is 80 GB, the capacity level of the geological database can be extended to 41 × 105TB using the method proposed in this study. The retrieval efficiency is higher than 89% and the resource occupancy rate is lower than 12% after the horizontal expansion of the database. By using this research method, the horizontal expansion of the geological drilling database is more effective, and can effectively reduce the resource occupancy rate and retrieval efficiency of the geological drilling databases. This has value significance for geological drilling with efficiency improvement and development.
“The Authors” Make Me Think Equally of Women and Men: Exploring Mixed-Gender Representations in a Visual Categorisation Task
Authors: Kim Jonathan D. , Öttl Anton , Gygax Pascal , Behne Dawn M. , Hyönä Jukka , Gabriel Ute 
Published: December 2023

Abstract
A common goal for gender-fair language policies is to promote terms that elicit balanced activation of gender categories. Expanding previous research on the activation of feminine versus masculine categories through person nouns, we used a word-picture response priming design with gendered human faces as target stimuli, to explore whether a simultaneous activation of more than one gender category can be captured empirically. Focusing on Norwegian (Bokmål), we tested whether reading stereotypical (i.e. role nouns, e.g. “care givers”) and categorical gendered person nouns (i.e. name pairs, e.g. “Elin and Sandra”) facilitates the categorisation of face pairs that match the gender of the designated people. In Experiment 1 (N = 32), gender-specific (feminine or masculine) word primes were tested, before gender-balanced word primes (non-stereotyped role nouns; pairs of a female and a male name) were added in Experiment 2 (N = 39). In both experiments, the visual targets were pairs of faces (two female faces, two male faces, or one male and one female face). Consistent with previous results for English, we found gender-specific priming effects, supporting the notion that gender categories activated by linguistic stimuli may also exert influence outside of language processing. Most importantly, mixed-gender faces were successfully primed by non-stereotypical role nouns providing initial support for the idea of a balanced activation of gender categories.
Machiavellis Kriegskunst: Die Lehren des Libro dell’arte della guerra
Authors: Frömmer Judith 
Published: December 2023

Abstract
For the most part, Machiavelli’s Libro dell’arte della guerra has been studied as a military treatise, which had produced different interpretations and applications. Whereas military historians assumed that Machiavelli somewhat underestimated the role of the so-called gunpowder revolution, recent scholarship stresses the political dimensions of the text and its reception in different contexts. This article focuses on the poetics of the dialogue, which cannot be reduced to propositional contents. Instead of teaching specific strategies and tactics of warfare, the Libro engages its readers in a military dialogue in a more radical sense. It enacts the very dynamics of war and battle by staging the complex and often contradictory conditions and foundations of speech and (military and political) theory on the one hand and its potential interactions with conflicting historical realities on the other. By combining different generic traditions of the literary dialogue from Plato to Cicero and Petrarch it performs a Machiavellian arte della guerra as the very form of military and militant intervention which concerns not only the practice of warfare, but human activity as such.
Ziel und Zweck als Ursachen im Siglo de Oro
Authors: Strosetzki Christoph 
Published: December 2023

Abstract
Teleological thinking dominates in the early modern period. According to Aristotle, man’s goal is happiness in the community. For Hobbes, who sees man as a wolf, there is no such goal. Whereas in antiquity Xenophon had spoken of a universal purposefulness in which the goal of all things is usefulness to man, the goal cause pre-exists as thought in the consciousness of man, whereby idleness is to be rejected. The merchant pursues the goal of supplying the community with goods that are not locally available. In money lending, the main goal can be charity and the hope of profit is only the secondary goal. The military’s objective is to prevent peace and to restore the disturbed order in a just war. If, according to Perez de Moya, the multitude of stars have the purpose of serving illumination at night, decorating the sky, or influencing things on earth, for example, by causing disease in humans, then they are also relevant to medical activity. Since the soul is purpose for the body, diseases are reactions to negative affects of the soul, such as anger or fear.
Impacto do uso de dispositivos eletrônicos na visão das crianças em idade escolar
Authors: Carneiro Bruna Ribeiro , Skonieczny Nattally Edimeire , Spinello Analice Horn , Candido de Bortoli Cleunir de Fátima 
Published: December 2023

Objetivo: conhecer o impacto das telas sobre a acuidade visual das crianças em idade de quatro a 12 anos, na perspectiva dos pais e responsáveis. Método: estudo quantitativo, descritivo, com 176 participantes. O convite ocorreu por mensagens enviadas nas redes sociais e a coleta através de um questionário online, entre fevereiro e abril de 2021. A análise ocorreu pelas frequências simples dos dados. Resultados: 50,57% tiveram o primeiro contato com as telas, antes de dois anos de idade. As queixas mais frequentes após uso de telas são: dores de cabeça, irritação visual, olhos ressecados e lacrimejando, visão turva e tonturas. 20,45% das crianças possuem dificuldades com de visão em grandes distancias e 60,80% das crianças, já realizaram avaliação oftalmológica. Conclusão: há um crescente número de crianças expostas precocemente e durante prolongados períodos, aos aparelhos eletrônicos de forma demasiada.
EVALUATING NANDINI RIVER WATER QUALITY: A SYSTEMATIC REVIEW OF PHYSICOCHEMICAL STUDIES
Authors: Dhande Bhagyashri S , Narkhede Rajendra S 
Published: December 2023

The quality of water is described to be the condition of the water, which includes the three basic forms of physical, chemical, and biological notions. Salinity, turbidity, the amount of dissolved oxygen and carbon dioxide, and microorganisms, herbicides, and pesticides along with the presence of heavy metals edit reminds to have a direct effect on the water quality. Because the universal solvent is a major factor affecting the lives of the humongous population of people, recognition of the quality of water is significantly important. Due to the fact that the presence of contaminants in water can directly lead to health issues such as reproductive problems, different kinds of neurological disorders, and gastrointestinal diseases, it is of vehement importance to understand the water quality. Nandini River flows through the Nashik city of Maharashtraand it is the tributary of the river Godavari which is is a vital source of water for the people of the Nashik region.Travelling from the heart of Nashik the river Nandini is faced with several issues related to its degrading water quality. Hence, the study sheds light onto the quality of water of the Nandini river, in terms of Physicochemical Studies.
Incorporation of Cloud Computing Services During the Knowledge Management Life Cycle: An Amalgamated Framework
Authors: Alawneh Ali Ahmad 
Published: December 2023

Knowledge has been utilized as a leverage by many businesses organization In the Era of Knowledge economy, as it is considered scarce, valuable and cognitive asset. Accordingly, managing that knowledge is considered a fundamental challenge for business managers to obtain the greatest value from it because of its profound impact on employees, business processes, and products, as well as to give organizations a sustainable competitive advantage in light of the hyper competition between businesses. This study aims to integrate cloud computing services within the life cycle of knowledge management, with the aim of benefiting from the cloud computing services model (IaaS, PaaS, SaaS) as a breaking-through technological infrastructure to support the four processes of knowledge management (discovery, capture, sharing, application). It is expected that the proposed framework will serve as a reference for employees in knowledge economy organizations to infuse cloud computing services within the processes of creating, possessing, transferring and applying knowledge, which will have a fundamental impact on management practices in the areas of planning, problem-solving, decision-making and policymaking.
Sakrament małżeństwa w dziewiętnastej księdze Dekretu biskupa Burcharda z Wormacji
Authors: Story Marek 
Published: December 2023

Księgi pokutne, które powstały w epoce późnej starożytności chrześcijańskiej i wczesnego średniowiecza, są świadectwem kształtowania się praktyki pokutnej w Kościele. Celem artykułu jest ukazanie w świetle dziewiętnastej księgi Dekretu biskupa wormackiego Burcharda niewłaściwych zachowań godzących w sakrament małżeństwa, które powodowały obciążenie winnych dotkliwymi karami – pokutami wymagającymi odpowiedniego zadośćuczynienia, często trudnego do realizacji. Biskup z Wormacji, dostrzegając szerzący się upadek obyczajów w kwestii wierności małżeńskiej, zobowiązał spowiedników, aby w czasie spowiedzi zwracali uwagę na sprawę nierozerwalności małżeństwa – zdarzały się bowiem przypadki wielożeństwa, czy nawet małżonkobójstwa w celu zawarcia nowego związku. Duszpasterze mieli także dążyć do tego, by poprzez pokutę wyeliminować niewłaściwe zachowania seksualne penitentów z członkami rodzin (współżycie ze szwagierką lub macochą), czy też namawianie współmałżonka do zdrady. W czasie sprawowania sakramentu pokuty odnoszono się ponadto do zagadnień związanych z przeszkodami do zawarcia małżeństwa, do których zaliczano chociażby przeszkodę pokrewieństwa, powinowactwa, czy też uprowadzenia kobiety w celu zawarcia z nią związku małżeńskiego oraz podkreślano znaczenie zaręczyn jako ważnego etapu do zawarcia małżeństwa.
THERMAL STRESSES IN COMPOSITE STEEL-CONCRETE BRIDGES DURING CONSTRUCTION STAGE
Authors: Flaga K. , Pańtak М. 
Published: December 2023

In the paper the analysis of stresses in concrete deck of steel-concrete composite bridges due to cumulative impacts of cement heat of hydration and ambient temperature have been presented. Examples of analyses of thermal conditions and thermal stresses in construction stage of composite road bridge have been shown.