bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategy for Targeting Medical Diagnosis of Cerebral Ischemia Regions by Linking Gsk-3β Antibody and RVG29 to Magnetosomes
Authors: Wang Qing , Li Xianyu 
Published: November 2023

Background:
In our previous studies, we have identified Gsk-3β as a crucial target
molecule in response to Danhong injection for cerebral ischemia intervention. Furthermore, it
can serve as a molecular imaging probe for medical diagnosis. Bacterial magnetic particles
(BMPs), synthesized by magnetotactic bacteria, are regarded as excellent natural nanocarriers.

Methods:
In this study, we utilized biological modification and chemical crosslinking techniques
to produce a multifunctional BMP known as "RVG29-BMP-FA-Gsk-3β-Ab", which exhibits
both magnetic properties and brain-targeting capabilities. Then, a combination of analytical
techniques was used to characterize the properties of the multifunctional BMPs. Finally, we
evaluated the cell targeting ability of the RVG29-BMP-FA-Gsk-3β-Ab.

Results:
The multifunctional BMPs were observed to possess uniform size and shape using
TEM analysis, with a particle size of 70.1±7.33 nm. Zeta potential analysis revealed that the
nanoparticles exhibited a regular and non-aggregative distribution of particle sizes. Relative
fluorescence intensity results demonstrated that the complex of 1mg of RVG29-BMP-FA-Gsk-
3β-Ab could bind to FITC-RVG29 polypeptide at a concentration of 2189.5 nM. Cell viability
analysis indicated its high biocompatibility and minimal cytotoxicity. The RVG29-BMP-FAGsk-
3β-Ab was observed to possess active targeting towards neuronal cells and fluorescence
imaging capabilities in vitro, as evidenced by fluorescence imaging assays. The complex of
RVG29-BMP-FA-Gsk-3β-Ab exhibited favourable properties for early diagnosis and efficacy
evaluation of traditional Chinese medicine in treating cerebral ischemia.

Conclusion:
This study establishes a fundamental basis for the prospective implementation of
multimodal imaging in traditional Chinese medicine for cerebral ischemia.
Identification of Novel Signals Associated with US-FDA Approved Drugs
(2013) Using Disproportionality Analysis
Authors: Raghuvanshi Sourabh , Rahman Mohammad Akhlaquer , Posa Mahesh Kumar , Kumar Anoop 
Published: November 2023

Background:
Drugs are related with various adverse drug reactions (ADRs), however,
many unexpected ADRs of drugs are reported through post-marketing surveillance.

Aim:
The current study's goal is to uncover potential signals connected with FDA-approved medications
in the United States (2013).

Methods:
Open Vigil 2.1-MedDRA-v24 (data 20004Q1-2021Q3) was used as a tool to query the
FAERS data. To find possible signals, disproportionality measures such as Proportional Reporting
Ratio (PRR 2) with associated Chi-square value, Reporting Odds Ratio (ROR 2) with 95%
confidence interval, and case count (3) were calculated

Results:
A total of eight potential signals were identified with five drugs. Positive signals were
found with pomalidomide, canagliflozin, dolutegravir sodium, macitentan and ibrutinib.

Conclusion:
However, further causality assessment is required to confirm the association of these
drugs with identified potential signals.
Assessing the Usefulness of Mobile Apps for Noise Management in Occupational Health and Safety: Quantitative Measurement and Expert Elicitation Study
Authors: Huyan Jingchen , Ramkissoon Chandnee , Laka Mah , Gaskin Sharyn 
Published: November 2023

Abstract

Background
Overexposure to occupational noise can lead to hearing loss. Occupational noise mapping is conventionally performed with a calibrated sound level meter (SLM). With the rise of mobile apps, there is a growing number of SLM apps available on mobile phones. However, few studies have evaluated such apps for accuracy and usefulness to guide those with occupational noise detection needs in selecting a quality app.

Objective
The purpose of this study was to evaluate the accuracy and usefulness of SLM mobile apps to guide workplace health and safety professionals in determining these apps’ suitability for assessing occupational noise exposure.

Methods
The following three iOS apps were assessed: the NIOSH (National Institute for Occupational Safety and Health) Sound Level Meter, Decibel X, and SoundMeter X apps. The selected apps were evaluated for their accuracy in measuring sound levels in low-, moderate-, and high-noise settings within both simulated environments and real-world environments by comparing them to a conventional SLM. The usefulness of the apps was then assessed by occupational health specialists using the Mobile App Rating Scale (MARS).

Results
The NIOSH Sound Level Meter app accurately measured noise across a range of sound levels in both simulated settings and real-world settings. However, considerable variation was observed between readings. In comparison, the Decibel X and SoundMeter X apps showed more consistent readings but consistently underestimated noise levels, suggesting that they may pose a risk for workers. Nevertheless, none of the differences in sound measurements between the three apps and the conventional SLM were statistically significant (NIOSH Sound Level Meter: P=.78; Decibel X: P=.38; SoundMeter X: P=.40). The MARS scores for the three apps were all above 3.0, indicating the usefulness of these apps.

Conclusions
Under the conditions of this study, the NIOSH Sound Level Meter app had equivalent accuracy to the calibrated SLM and a degree of usefulness according to the MARS. This suggests that the NIOSH Sound Level Meter app may be suitable for mapping noise levels as part of a monitoring strategy in workplaces. However, it is important to understand its limitations. Mobile apps should complement but not replace conventional SLMs when trying to assess occupational noise exposure risk. Our outcomes also suggest that the MARS tool may have limited applicability to measurement-based apps and may be more suited to information-based apps that collect, record, and store information.
Patient and Provider Experiences With a Digital App to Improve Compliance With Enhanced Recovery After Surgery (ERAS) Protocols: Mixed Methods Evaluation of a Canadian Experience
Authors: Beesoon Sanjay , Drobot Ashley , Smokeyday Melissa , Ali Al-Bakir , Collins Zoe , Reynolds Colin , Berzins Sandra , Gibson Alison , Nelson Gregg 
Published: November 2023

Background
Of all the care provided in health care systems, major surgical interventions are the costliest and can carry significant risks. Enhanced Recovery After Surgery (ERAS) is a bundle of interventions that help improve patient outcomes and experience along their surgical journey. However, given that patients can be overwhelmed by the multiple tasks that they are expected to follow, a digital application, the ERAS app, was developed to help improve the implementation of ERAS.

Objective
The objective of this work was to conduct a thorough assessment of patient and provider experiences using the ERAS app.

Methods
Patients undergoing colorectal or gynecological oncology surgery at 2 different hospitals in the province of Alberta, Canada, were invited to use the ERAS app and report on their experiences using it. Likewise, care providers were recruited to participate in this study to provide feedback on the performance of this app. Data were collected by an online survey and using qualitative interviews with participants. NVivo was used to analyze qualitative interview data, while quantitative data were analyzed using Excel and SPSS.

Results
Overall, patients found the app to be helpful in preparation for and recovery after surgery. Patients reported having access to reliable unbiased information regarding their surgery, and the app provided them with clarity of actions needed along their surgical journey and enhanced the self-management of their care. Clinicians found that the ERAS app was easy to navigate, was simple for older adults, and has the potential to decrease unnecessary visits and phone calls to care providers. Overall, this proof-of-concept study on the use of a digital health app to accompany patients during their health care journey has shown positive results.

Conclusions
This is an important finding considering the massive investment and interest in promoting digital health in health care systems around the world.
Dentists’ Information Needs and Opinions on Accessing Patient Information via Health Information Exchange: Survey Study
Authors: Li Shuning , Felix Gomez Grace Gomez , Xu Huiping , Rajapuri Anushri Singh , Dixon Brian E , Thyvalikakath Thankam 
Published: November 2023

Background
The integration of medical and dental records is gaining significance over the past 2 decades. However, few studies have evaluated the opinions of practicing dentists on patient medical histories. Questions remain on dentists’ information needs; their perception of the reliability of patient-reported medical history; satisfaction with the available information and the methods to gather this information; and their attitudes to other options, such as a health information exchange (HIE) network, to collect patient medical history.

Objective
This study aims to determine Indiana dentists’ information needs regarding patients’ medical information and their opinions about accessing it via an HIE.

Methods
We administered a web-based survey to Indiana Dental Association members to assess their current medical information-retrieval approaches, the information critical for dental care, and their willingness to access or share information via an HIE. We used descriptive statistics to summarize survey results and multivariable regression to examine the associations between survey respondents’ characteristics and responses.

Results
Of the 161 respondents (161/2148, 7.5% response rate), 99.5% (n=160) respondents considered patients’ medical histories essential to confirm no contraindications, including allergies or the need for antibiotic prophylaxis during dental care and other adverse drug events. The critical information required were medical conditions or diagnosis, current medications, and allergies, which were gathered from patient reports. Furthermore, 88.2% (n=142) of respondents considered patient-reported histories reliable; however, they experienced challenges obtaining information from patients and physicians. Additionally, 70.2% (n=113) of respondents, especially those who currently access an HIE or electronic health record, were willing to use an HIE to access or share their patient’s information, and 91.3% (n=147) shared varying interests in such a service. However, usability, data accuracy, data safety, and cost are the driving factors in adopting an HIE.

Conclusions
Patients’ medical histories are essential for dentists to optimize dental care, especially for those with chronic conditions. In addition, most dentists are interested in using an HIE to access patient medical histories. The findings from this study can provide an alternative option for improving communications between dental and medical professionals and help the health information technology system or tool developers identify critical requirements for more user-friendly designs.
Daily Activity Lifelogs of People With Heart Failure: Observational Study
Authors: Tegegne Teketo Kassaw , Tran Ly-Duyen , Nourse Rebecca , Gurrin Cathal , Maddison Ralph 
Published: November 2023

Background
Globally, heart failure (HF) affects more than 64 million people, and attempts to reduce its social and economic burden are a public health priority. Interventions to support people with HF to self-manage have been shown to reduce hospitalizations, improve quality of life, and reduce mortality rates. Understanding how people self-manage is imperative to improve future interventions; however, most approaches to date, have used self-report methods to achieve this. Wearable cameras provide a unique tool to understand the lived experiences of people with HF and the daily activities they undertake, which could lead to more effective interventions. However, their potential for understanding chronic conditions such as HF is unclear.

Objective
This study aimed to determine the potential utility of wearable cameras to better understand the activities of daily living in people living with HF.

Methods
The “Seeing is Believing (SIB)” study involved 30 patients with HF who wore wearable cameras for a maximum of 30 days. We used the E-Myscéal web-based lifelog retrieval system to process and analyze the wearable camera image data set. Search terms for 7 daily activities (physical activity, gardening, shopping, screen time, drinking, eating, and medication intake) were developed and used for image retrieval. Sensitivity analysis was conducted to compare the number of images retrieved using different search terms. Temporal patterns in daily activities were examined, and differences before and after hospitalization were assessed.

Results
E-Myscéal exhibited sensitivity to specific search terms, leading to significant variations in the number of images retrieved for each activity. The highest number of images returned were related to eating and drinking, with fewer images for physical activity, screen time, and taking medication. The majority of captured activities occurred before midday. Notably, temporal differences in daily activity patterns were observed for participants hospitalized during this study. The number of medication images increased after hospital discharge, while screen time images decreased.

Conclusions
Wearable cameras offer valuable insights into daily activities and self-management in people living with HF. E-Myscéal efficiently retrieves relevant images, but search term sensitivity underscores the need for careful selection.
FACTORS INFLUENCING STUDENTS’ SPEAKING ANXIETY AT ONE PUBLIC UNIVERSITY IN JAMBI: PERSONALITY TRAITS, MOTIVATION, AND FAMILY ENVIRONMENT ASPECTS
Authors: Miftahudin Miftahudin , Abrar Mukhlash , Habizar Habizar 
Published: November 2023

This research aimed to describe factors that influence students’ speaking anxiety and to explore the strategies used by the students to overcome their anxiety. The site of this research was at one public university in Jambi. The researcher utilised purposive sampling technique in selecting the participants. There were 12 participants of this research which including 7th semester students, 5th semester students, and 3rd semester students who have passed speaking classes. This research employed qualitative study with case study approach in one English teacher study program. In collecting the data, the researcher used interview and documentation as the data collection.
The results of this research indicated that there were still several factors faced by the students which influenced their speaking anxiety. Those factors were afraid, shy, unconfident, overthinking, nervous, mood, low motivation, and family support. The most factors felt by the students were overthinking and unconfident. This research also pointed out that the participants used several strategies to overcome their anxiety in speaking. There were 9 strategies employed by the participants including taking a deep breathe, practicing, being confident, calming down, studying hard, being well-prepared, being alone, discussing with friends, and getting motivation from friends.
STUDENTS' PERCEPTION ON THE USE OF WHATSAPP APPLICATION FOR ONLINE LEARNING DURING THE COVID-19 PANDEMIC
Authors: Samsiya Samsiya , Hidayat Marzul , Abrar Mukhlash 
Published: November 2023

The impact of the spread of the covid-19 virus on the world of education requires educators and students to be adapted quickly to existing changes. Before the pandemic, the learning activity was original to be held face-to-face directly in the classroom, however, an integrated learning system through the virtual internet network (online learning) must be implemented during the pandemic. The implementation of English learning for students was still done online using WhatsApp. Based on this, the purpose of this study was to investigate students’ perceptions on the use of the WhatsApp application for online learning during the covid-19 pandemic.
This study employed quantitative research with a survey method. This study used questionnaire data to collect the data. The results of questionnaire data analysis indicated that 122 of 168 respondents gave a good perception of the use of the WhatsApp application. In addition, the teacher used the features provided in the WhatsApp application, such as messages, voice messages, documents, videos, and images to improve students’ ability and evaluate the extent of students’ ability with the material that had been studied.
The conclusion of the study is the existence of the benefits of WhatsApp media that teachers can use for learning English. Because WhatsApp has many advantages that support learning, this application can be used to send text messages, download and upload images, documents, or videos, and send voice messages.
LEXICAL ATTRITION IN MULTILINGUAL LANGUAGE LEARNERS
Authors: Ulfiati Lilik 
Published: November 2023

Multilingual language learners are facing various challenges of language attrition, both internally and externally. Lexical attrition is one of phenomena experienced by the learners since they can no longer do something which s/he had previously been able to do, and this loss of proficiency is not caused by deterioration of the brain due to age, illness or injury, but by changes in linguistic behaviour due to severance of the contact with the community in which the language is spoken (Smith, 2017). This article is trying to capture the studies of lexical attrition in the multilingual contexts and suggest several improvement strategies in experiencing the lexical attrition. This study is using content analysis to explore existing literature on lexical attrition in multilingual language learners over the last ten years. A summary of more than seventeen is provided along with the content analysis. The finding of these studies gives a significant contribution to the field of language attrition that focuses on practical analysis in learners or speakers points of view in the multilingual context. It shows that the limitation of understanding on lexical attrition concept from the local authorities in many educational settings have resulted in less efficient and effective language maintenance.
RESPON PETANI TERHADAP PENGENALAN TEKNOLOGI DAN MANAJEMEN PABRIK KELAPA SAWIT MINI
Authors: Rahman A , Kernalis Emy , Saputra Ardhiyan , Rosyani Rosyani , Zakiah Zakiah 
Published: November 2023

Cita-cita petani kelapa sawit memiliki pabrik CPO sudah menjadi wacana secara nasional maupun lokal. Untuk mewujudkan cita-cita itu tentu menghendaki pengetahuan dan pemahaman yang cukup dari petani tentang deskripsi pabrik tersebut, bagaimana teknologi dan bagaimana manajemennya. Permasalahannya adalah tidak semua petani paham atau mengerti tentang bagaimana proses membangun pabrik, teknologi yang digunakan, dan sistem pengelolaannya serta manfaat apa yang akan diterimanya. Untuk mewujudkan hal itu maka petani/pekebun perlu diberi ruang yang cukup dalam cara berpikir dan bertindak sehingga keputusan yang diambil merupakan keputusan kolektif. Penyuluhan tentang pengenalan teknologi, manajemen dan pabrik kelapa sawit mini menuju kemandirian petani dalam pengelolaan TBS di KUD Marga Jaya Desa Petaling untuk mendapatkan pengetahuan tentang teknologi dan pengelolaan pabrik CPO, dan pengetahuan tentang pabrik CPO berskala mini. Kegiatan ini dilaksanakan ditengah Pandemi Covid -19 sehingga peserta hanya dipilih dari para ketua kelompok tani dan pengurus KUD. Hasilnya menunjukkan bahwa respon terhadap pelaksanaan sosialisasi cukup baik dan disertai harapan terjadi transfer pengetahuan secara lebih luas dan berkesinambungan di tengah petani kelapa sawit setempat.
Analisis Efektiktifitas Pemasangan Proteksi Petir Berdasarkan Tingkat Ancaman Sambaran Petir Cloud to Ground di Titik Tower Transmisi Air Anyir - Pangkalpinang
Authors: Hanung Yoba Abriyanto  
Published: November 2023

Intisari — Pulau Bangka merupakan bagian dari provinsi Kepulauan Bangka Belitung dengan kondisi geografis di kelilingi laut sehingga berpotensi memiliki curah hujan tinggi disertai petir. Berdasarkan analisis pareto gangguan kelistrikan transmisi Bangka, penyebab gangguan tertinggi adalah sambaran petir. Tujuan penelitian ini adalah menganalisis tingkat ancaman sambaran petir pada titik tower transmisi dan kelayakan ekonomi investasi pemasangan proteksi petir di titik tower transmisi sehingga didapatkan optimasi titik pemasangan proteksi petir dengan biaya investasi yang lebih optimal. Objek penelitian di fokuskan pada penghantar transmisi Air Anyir-Pangkalpinang. Pendekatan analisa penelitian yaitu dengan perhitungan tingkat potensi ancaman sambaran petir dari data history tahun 2019-2021 yang diambil dari aplikasi pengolah data FALLS (Fault Analysis and Lightning Location Software). Hasil perhitungan analisa tingkat potensi ancaman sambaran tinggi dengan nilai kerapatan sambaran diatas 1,90 sambaran per km2 adalah tower 12, tower 16, tower 23, tower 24, tower 25 dan tower 26. Analisa kelayakan ekonomi investasi didasarkan pada perhitungan Internal Rate of Return (IRR), Net Present Value (NPV), Payback Period (PP) dan Benefit Cost Ratio (BCR). Hasil analisis kelayakan ekonomi investasi pemasangan diseluruh titik tower Air Anyir-Pangkalpinang didapatkan nilai NPV Positif sebesar Rp 2.573.916.460,39, nilai IRR sebesar 19,16%, nilai PP selama 9 tahun dan nilai BCR sebesar 4,75. Sedangkan untuk analisis kelayakan ekonomi pemasangan proteksi petir di titik tower berdasarkan hasil perhitungan analisa potensi peluang sambaran petir tinggi didapatkan nilai NPV Positif sebesar Rp 3.766.891.465,59, nilai IRR sebesar 60,63%, nilai PP selama 3 tahun dan nilai BCR sebesar 14,90.
Kata Kunci — Sambaran Petir, FALLS, Efektifitas, Analisis Ekonomi
Kajian Unsur Intrinsik dan Nilai Budaya pada Legenda Sang Kuriang Kesiangan sebagai Alternatif Bahan Ajar Bahasa dan Sastra Indonesia di SMP
Authors: Rodiah Siti 
Published: November 2023

Penelitian ini bertujuan untuk mengkaji unsur intrinsik dan nilai budaya pada Legenda Sang Kuriang Kesiangan. Hal ini dilakukan sebagai alternatif bahan ajar Bahasa dan Sastra Indonesia di kelas VII. Penelitian ini menggunakan jenis penelitian kualitatif. Data yang diperoleh dalam penelitian ini berupa unsur intrinsik dan nilai budaya pada Legenda Sang Kuriang Kesiangan, serta wawancara dengan instruktur nasional, pengawas, dan guru Bahasa Indonesia. Data unsur intrinsik tersebut meliputi: tema, tokoh dan penokohan, latar/ setting, alur, gaya bahasa, sudut pandang, dan amanat. Data nilai budaya meliputi: bahasa, sistem pengetahuan, organisasi sosial, sistem peralatan hidup dan teknologi, sistem mata pencaharian hidup, sistem religi, dan kesenian. Hasil kajian terhadap unsur intrinsik dan nilai budaya Legenda Sang Kuriang Kesiangan dilihat dari Kurikulum 2013, bahan ajar berupa bahasa, psikologi, dan latar budaya peserta, serta wawancara dengan nara sumber. Berdasarkan hal itu, maka diperoleh jawaban bahwa Legenda Sang Kuriang Kesiangan dikategorikan baik dan layak dijadikan alternatif bahan ajar pada mata pelajaran Bahasa Indonesia di SMP kelas VII.