bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palliative Care progress in Benin: a situation analysis using the WHO development indicators
Authors: AGBODANDE Kouessi Anthelme , GNANGNON Freddy , ASSOGBA Mickael , AVAKOUDJO Josué , KOUANOU Angèle AZON , ODOULAMY Lisette , DAHO Jean , ZANNOU Djimon Marcel , SALIFOU Sourakatou , Ali IMOROU BAH CHABI , SAIZONOU Raoul , Issimouha DILLE MAHAMADOU , Fernanda BASTOS , GARRALDA Eduardo , Centeno Carlos , TRIPODORO Vilma 
Published: December 2023

Abstract

Context
Palliative care (PC) situation in most African countries remains underdiagnosed. Benin has piloted the implementation of a set of indicators proposed by the WHO to measure PC development.
Objectives
To examine the current state of PC in Benin.
Methods
A workshop with stakeholders was organized to validate the WHO indicators in the Beninese context. Indicators were rated by relevance and feasibility, data sources were agreed, and a survey adapted. Data were collected between March and May 2023.
Results
There is emerging community involvement in PC through the presence of patients' rights promoters, as well as a political commitment expressed in the National PC strategy, the inclusion of PC services in the list of basic health services, and an assigned national authority –within the Ministry of Health- responsible for PC. While no PC-oriented research is documented, the celebration of the National PC Conference represents a first step to ground PC delivery in evidence. Reported annual consumption of opioids is 0.18 (ME) milligrams per capita, 34% of healthcare establishments have essential medicines for pain and PC and 16.5% of patients with palliative needs have access to oral morphine. To date, none of the medical or paramedical schools offers PC training and there is no official specialization in palliative medicine for doctors. PC is provided by 11 specialist teams (0.08/100,000 inhabitants) none of which provide pediatric care.
Conclusion
Despite growing political, professional, and community commitment, there are challenging shortcomings in education, research, essential medicines, and access to PC services.
First report and genetic characterization of Aeromonas dhakensis in Aldabra giant tortoise
Authors: Zhao Chenxu , Li Shuai , Chen Zilu , Wang Tianliang , Liang Qunchao , He Weishi , Qin Panpan , Peng Zeyu , Yang Yurong , Peng Zhifeng , Li Yongtao 
Published: December 2023

Abstract
Aeromonas dhakensis (A. dhakensis) is becoming an emerging pathogen worldwide, with an increasingly significant role in animals and human health. It is a ubiquitous bacteria found in terrestrial and aquatic milieus. However, there have been few reports of reptile infections. In this study, a bacterial strain isolated from a dead Aldabra giant tortoise was identified as A. dhakensis HN-1 through clinical observation, matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF/MS), and gene sequencing analysis. Subsequently, to evaluate its pathogenicity, the detection of virulence genes and mice infection experiments were performed. A. dhakensis HN-1 was found to contain seven virulence genes, including alt, ela, lip, act, aerA, fla, and hlyA. Mice infected with A. dhakensis HN-1 exhibited hemorrhage of varying degrees in multiple organs. The half-maximal lethal dose (LD50) value of A. dhakensis HN-1 for mice was estimated to be 2.05×107 colony forming units (CFU)/mL. The antimicrobial susceptibility test revealed that A. dhakensis HN-1 was resistant to rifampicin, ciprofloxacin, amoxicillin, ampicillin, penicillin, and erythromycin. This is the first report of A. dhakensis in Aldabra giant tortoises, expanding the currently known host spectrum. Our results highlight the emergency of One Health surveillance and extensive research to minimize the transmission of A. dhakensis among the environment, humans, and animals.
Gallic acid - polyethyleneimine modified UHMWPE fibers with Epoxy Resin for Investigating Interfacial Properties
Authors: Wang Ziming , Zhu Xinyi , Yu Qiang , Feng Xia , Zhao Yiping , Chen Li 
Published: December 2023

Abstract
In this paper, a safe, non-toxic, and low-cost method was adopted to modify ultra-high molecular weight polyethylene (UHMWPE) fibers. gallic acid (GA) and polyethyleneimine (PEI) were co-deposited on the surface of UHMWPE fibers by Michael addition and Schiff base reaction in an alkaline solution with pH 8.5. The structure and properties were analyzed and characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), Thermogravimetric Analyzer (TG), etc. The morphology of the UHMWPE fibers and the degree of firmness of the surface coatings were observed by Scanning Electron Microscope (SEM), and the effects of different mass ratios of GA-PEI on the UHMWPE fibers were investigated. The results showed that the surface active functional groups of the modified UHMWPE fibers increased, and the bending properties and interfacial shear strength of the composites with epoxy resin were significantly improved, with the bending strength and interfacial shear strength increased by 33.1 % and 45.9 %, respectively.
Nuclear expansion drives chromatin structure remodeling in aging neurons
Authors: Toiber Debra , Kruikov Dmitrii , Eremenko Ekaterina , Smirnov Dmitrii , Stein Daniel , Tsitrina Alexandra , Golova Anastasia , Einav Monica , Khrameeva Ekaterina 
Published: December 2023

Abstract
Aging, particularly in the brain, involves impairments in multiple cellular and molecular functions, many of which are regulated at the nucleus. Chromatin structure plays a critical role in the regulation of gene expression and the maintenance of genomic stability. During differentiation, chromosomes acquire their unique topology depending on the cell type that should be kept for a lifetime, but this may deteriorate as we age. However, the effects of aging on the chromatin 3D structure of neurons remain largely unknown and much has been inferred from senescent cells. By combining chromosome conformation capture and microscopy techniques, we investigated cortical neurons of young and aged mice and discovered neuronal nuclear expansion during neuronal aging, leading to increased distances between chromosomes. This expansion alters the topology of compartments, topologically associating domains (TADs) and chromatin loops. While larger TADs tend to dissociate, smaller TADs and loops exhibit strengthened interactions to maintain the cohesiveness of chromatin in aged neurons. These topological changes impact the borders of TADs, resulting in their overall weakening. Interestingly, we attribute these alterations to changes in the physical forces of an expanding nucleus, filling a growing nuclear area, affecting downstream gene expression and chromatin topology, further contributing to the functional declines observed during aging.
The efficacy of Levonorgestrelintrauterine system, Drospirenone &amp; Ethinylestradiol Tablets(II) and Dydrogesterone in preventing the recurrence of endometrial polyps
Authors: Jiang Yao , Li Xiumei , Wu Jun , Jiang Chen , Yang Yanhua , Wei Hui 
Published: December 2023

Abstract
Objective: To analyze the efficacy of Levonorgestrelintrauterine system, Drospirenone & Ethinylestradiol Tablets(Ⅱ), and Dydrogesterone in preventing the recurrence of endometrial polyps after hysteroscopic endometrial polypectomy.
Methods: 170 patients who underwent hysteroscopic endometrial polypectomy in the Gynecology Department of Tianmen First People's Hospital in Hubei Province from January 2022 to June 2023 were randomly divided into the Levonorgestrelintrauterine system group, Drospirenone & Ethinylestradiol Tablets(Ⅱ) group, Dydrogesterone group, and a control group. The recurrence rates, endometrial thickness, and menstrual volume changes at 6 and 12 months post-operation were compared among these four groups.
Results: The recurrence rates in the Levonorgestrelintrauterine system group, Drospirenone & Ethinylestradiol Tablets(Ⅱ) group, and Dydrogesterone group were lower than the control group, with statistical significance (P < 0.01), with the Levonorgestrelintrauterine system group having the lowest recurrence rate. The endometrial thickness at 6 and 12 months post-operation in the Levonorgestrelintrauterine system group, Drospirenone & Ethinylestradiol Tablets(Ⅱ) group, and Dydrogesterone group was thinner than that of the control group and thinner than pre-operation, with statistical significance (P < 0.01). The menstrual volume at 3 months post-operation in the Levonorgestrelintrauterine system group, Drospirenone & Ethinylestradiol Tablets(Ⅱ) group, and Dydrogesterone group was significantly less than the control group, and less than the pre-operation volume.
Conclusion: Dydrogesterone, Drospirenone & Ethinylestradiol Tablets(Ⅱ), and Levonorgestrelintrauterine system all play a role in preventing the recurrence of endometrial polyps, but Levonorgestrelintrauterine system is significantly better than Dydrogesterone and Drospirenone & Ethinylestradiol Tablets(Ⅱ) in terms of post-operative recurrence rate, endometrial thickness, menstrual changes, and compliance, and is worth promoting in clinical application.
A cross-sectional study on the Arabic Version of the Adjustment Disorder–New Module20 for Cancer Patients: Tool Validation, Prevalence, and Risk Factors
Authors: Almaghrebi Asma H , Alhajjar Lynn , Alkusayer Asma , Zahrani Saeed Al , Jumah Mohammed Al 
Published: December 2023

Abstract
Background
Adjustment disorder (AjD) is a common mental health condition whose symptoms include the development of a group of emotional and behavioral disturbances caused by inadequate adaptation to stressors. Adjustment Disorder – New Module 20 (ADNM-20) is a tool used to assess the new diagnostic concept of AjD according to the International Classification of Diseases 11 (ICD-11). This study aimed to evaluate the validity of the Arabic version of the ADNM-20 and investigate the risk factors for and prevalence of AjD among cancer patients.
Methods
A total of 146 adult cancer patients were recruited from cancer societies in Saudi Arabia (SA) and King Saud Medical City, a tertiary care center in Riyadh, Saudi Arabia. Test–retest stability, internal consistency, and item-total correlations were used to assess the reliability and validity of the ADNM-20. A cutoff score of 47.5 with the ADNM-20 scale was used to determine the prevalence of AjD, and the characteristics of the group at high risk of AjD were highlighted.
Results
The Arabic version of the ADNM-20 has shown high reliability, with Cronbach’s α = 0.92. The test-retest correlation coefficient was 0.76, and the correlation between the subscales of ADNM-20 and the total scale was high. We found that 43.84% of adult cancer patients were at risk of AjD, and there were no significant differences between the scores of the hospital and community cancer patients. The risk factors in this study were being female, unemployment, exposure to multiple stressors or financial difficulties, and receiving chemotherapy.
Conclusions
Our results suggest that ADNM-20 is reliable, valid, and applicable for clinical use and research into AjD in cancer patients. Additional research is needed to validate a structured assessment of AjD symptoms in Arabic culture.
Pattern of Physical Growth and Pubertal Changes in Adolescent Girls with Systemic Lupus Erthythematosus
Authors: Nori Harshita , kaur harvinder , Singh Surjit , Bhalla Anil 
Published: December 2023

Abstract
Background
To study the pattern of physical growth and pubertal changes in adolescent girls with Systemic Lupus Erythematosus (SLE).
Methods
Weight, height, BMI, waist and hip circumference among 50 adolescent SLE girls (aged 8-17years), was cross-sectionally studied using standardised techniques and instruments. Breast development stage, presence or absence of pubic and axillary hair and age of attainment of menarche were also noted.
Results
With advancement of age, mean weight and height of SLE girls increased but they were lighter and shorter compared to normal Indian peers. 18.4% of study girls were short-statured while, only 1 participant was underweight. As per mid-parental height, 34.3% were predicted to have shorter final heights. BMI demonstrated an inconsistent trend with 12.3% and 9.2% being obese and overweight, respectively. Interestingly, 10.7% of SLE girls were at risk of metabolic syndrome (waist circumference > 70th centile). About 50% of study girls had attained menarche (mean age: 13.04 ± 1.38years). Appearance of pubic and axillary hair occurred around 1 year later than attainment of menarche. 33.80% of study subjects were in prepubertal stage of breast development and rest 66.20% were in advanced stages of breast development. SLE girls who had younger age at diagnosis and longer duration of therapy had significant delay in breast development and attainment of menarche.
Conclusions
SLE girls show delayed growth and pubertal attainments compared to their normal Indian and western counterparts. The data presented will provide understanding of the auxological dynamics and pattern of pubertal changes among adolescent girls with SLE living in north-western India.
The valuation of double barrier options under mixed fractional Brownian motion model with transaction costs
Authors: Rezaei Maryam 
Published: December 2023

Abstract
One of the phenomena observed in the real market is long-range dependence. Mixed fractional Brownian motion with Hurst parameter can be a suitable tool to capture it. The main objective of this work is to numerically evaluate the double barrier options base on the fractional Black-Scholes equation under mixed fractional Brownian motion model with transaction costs and time-dependent parameters in a discrete-time setting when the change in the option price with time follows a fractal transmission system. We solve the fractional Black-Scholes equation by using an implicit difference scheme. Also, we numerically investigate the influence of model parameters on the double barrier option price. Numerical results are presented to confirm the theoretical findings.
Mathematics Subject Classification. 60G22, 91G20, 91B25.
Particle Flow Numerical Simulation Model for Coal and Gas Outburst and Its Microscopic Outburst Mechanism Description
Authors: Jiao Huice , Song Weihua 
Published: December 2023

Abstract
The finite difference model and particle flow model were constructed to reproduce the process of coal and gas outburst in front of the tunnel. The reliability of the particle flow model was verified by studying the internal stress, gas pressure, and related parameters of gas and coal two-phase flow. Then the process of coal and gas outburst is described from a microscopic perspective. The results show that the particle flow numerical model of coal and gas outburst is in line with reality and can intuitively and conveniently monitor relevant parameters; The concentrated stress caused by excavation of tunnels can reach 1.2 times the in-situ stress; High stress causes the adhesion between coal particles to break down, which is the main reason for the initiation of coal and gas outbursts; The intermittent breakthrough of gas on the coal particle collection that blocks the release channel has caused pulsating characteristics of coal and gas outbursts.
Analyzing the Influence of Clostridium butyricum on Liver Health in Spotted Sea Bass (Lateolabrax maculatus) via Transcriptomics and Metabolomics
Authors: Kong Lumin , Ma Jianrong , Lin Hao , Zhou Sishun , Long Zhongying , Qin Huihui , Lin Yi , Liu Longhui , Huang Zhangfan , Li Zhongbao 
Published: December 2023

Abstract

Clostridium butyricum (CB) has received much attention as a probiotic; however, few studies have focused on its effects on liver health. Here, we studied the influence of CB on the liver health of spotted sea bass through transcriptomic and metabolomic studies and preliminarily explored its molecular mechanisms. This study showed that CB significantly reduced hepatic aspartate aminotransferase (AST) activity and increased alkaline phosphatase (AKP) and acid phosphatase (ACP) activity (P < 0.05). CB has demonstrated significant effects in strengthening liver immunity and can increase hepatic amylase and trypsin activities and promote hepatic catabolism of carbohydrates and amino acids. Integration of the liver Transcriptomics and metabolomics showed altered transcript levels of mainly gluconeogenic, lipogenic, and amino acid metabolic pathways. It regulated the abundance of metabolic biomarkers such as arachidonate, crotonyl-CoA, and D-glucose 1-phosphate. Our findings support that CB can reduce liver damage in spotted sea bass, enhance liver immunity, and improve liver metabolism.
M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis
Authors: Qian Yufan , Chu Genglei , Zhang Lei , Wu Zhikai , Wang Qiuyuan , Guo Jiong Jiong , Zhou Feng 
Published: December 2023

Abstract
Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived exosomes were isolated and identified. Exosomes were subjected to microRNA (miRNA) sequencing and bioinformatic analysis, and differentially expressed miRNAs were verified. miR-26b-5p target genes were confirmed through target-site mutation combined with a dual-luciferase reporter assay. The effects of miR-26b-5p on macrophage polarization and chondrocyte hypertrophy were assessed in vitro. miR-26b-5p agomir was applied to mice with OA induced by anterior cruciate ligament transection (ACLT). The therapeutic effects of miR-26b-5p were evaluated via pain behavior experiments and histological observations. In vitro, miR-26b-5p repolarized M1 macrophages to an anti-inflammatory M2 type by targeting the TLR3 signaling pathway. miR-26b-5p could target COL10A1, further inhibiting chondrocyte hypertrophy induced by M1 macrophage-conditioned medium (M1-CM). In vivo, miR-26b-5p agomir ameliorated gait abnormalities and mechanical allodynia in OA mice. miR-26b-5p treatment attenuated synovitis and cartilage degeneration, thereby delaying OA progression. In conclusion, M2 macrophage-derived exosomal miR-26b-5p could protect articular cartilage and ameliorate gait abnormalities in OA mice by targeting TLR3 and COL10A1. miR-26b-5p further affected macrophage polarization and chondrocyte hypertrophy. Thus, this exosomal miR-26b-5p-based strategy might be a potential method for OA treatment.
A mixed-methods evaluation of neurosurgical care in the public sector in Peru
Authors: Garcia Roxanna M , Williams Anna Larson , Niquen-Jimenez Milagros , Benllochpiquer Victor , Durand Walter , Reynolds Rebecca , Swaroop Mamta , Garcia Patricia J 
Published: December 2023

Abstract
Background
In Andean Latin America, an estimated 60% of the population is without access to surgical care. Neurosurgical conditions are a leading cause of disability and mortality. The purpose of this study was to perform national evaluation of neurosurgical services within the Peruvian Ministry of Health (MINSA), which provides healthcare to over 70% of the population.
Methods
This cross-sectional, descriptive study included site visits at MINSA facilities between 2019 to 2020. A quantitative survey of hospital resources was administered and semi-structured interviews with neurosurgeons were conducted. Hospital characteristics were descriptively summarized, and a qualitative analysis using grounded theory was performed in Nvivo software.
Results
A total of 25 (93%) of 27 facilities were visited nationally. Twenty recorded interviews were conducted and identified 170 neurosurgeons, resulting in 1 neurosurgeon to 172,835 patient population. Hospitals in Lima had mean higher numbers of hospital beds, operating rooms, and access to post-operative recovery, but over 42% (n = 5) reported greater than 4 hours to reach the operating room for emergent surgery once the patient was determined to need a neurosurgical intervention after arrival at index hospital. Twenty-eight percent (n = 7) lacked access to computed tomography scanner, and 76% (n = 19) lacked access to magnetic resonance imaging. Significant themes influencing access to neurosurgical care were lack or poor maintenance of basic materials, equipment and supplies, inadequate healthcare infrastructure, and poor financial prioritization. Consequently, delays to life-saving intervention and poor patient outcomes were common occurrences.
Conclusion
This study serves as a baseline evaluation of neurosurgical capacity for MINSA facilities. Context-specific factors were identified to help inform future interventions and policy decisions for neurosurgical preparedness.
Ovarian Cancer Management in an ESGO Ovarian Cancer Center of Excellence: A systematic case study of the interprofessional and interdisciplinary interaction
Authors: Krankenberg David , Muallem Mustafa Zelal , Pietzner Klaus , Chekerov Radoslav , Armbrust Robert , Beteta Carmen , Schöning Wenzel , Lee Marlene , Klews Ina , Sehouli Jalid 
Published: December 2023

Abstract
Purpose. With growing knowledge about ovarian cancer over the last decades diagnosis, evaluation and treatment in ovarian cancer patients has become highly specialized, and an individually adapted approach should be made in each woman by interdisciplinary cooperation. The present study aims to show the variety and extent of medical specialties involved at our institution according to the European Society of Gynecologic Oncology (ESGO) Quality indicators (QI). Methods. A woman, diagnosed with a high-grade ovarian cancer International Federation of Gynecology and Obstetrics (FIGO) IIIb was selected for a single case observational study. The observation period (total = 22d) comprised preoperative diagnostic procedures, including imaging, the in-patient stay for cytoreductive surgery, and the postoperative course and case discussion at our interdisciplinary tumor board. Data were obtained by self-reporting and by patient file review. Results. Patient-tracking demonstrated an interdisciplinary cooperation of 12 medical specialties (62 physicians [63% male, 37% female]) 8 different types of nursing staff (n = 59 [22% male, 78% female]) and 9 different types of peri-operative/administrative staff (n = 23; male 17,4%, female n = 19, 82,6%]). Contact with the patient was direct (n = 199; 76%) or without face-to-face interaction (n = 63; 24%). Conclusion. The present study demonstrates the high diversity of physicians and the affiliated medical staff as well as interdisciplinary intersections within teams of specialized hospitals. according to the ESGO QIs. This report underlines the requirement of an adequate infrastructure for the complex management of advanced ovarian cancer patients. Future prospective studies are warranted to evaluate the specific procedures and actions to optimize the interprofessional and interdisciplinary workflows.