bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haematological dynamics following treatment of visceral leishmaniasis: a protocol for systematic review and individual participant data (IPD) meta-analysis
Authors: Munir Abdalla , Dahal Prabin , Kumar Rishikesh , Singh-Phulgenda Sauman , Siddiqui Niyamat Ali , Naylor Caitlin , Wilson James , Buck Gemma , Rahi Manju , Alves Fabiana , Malaviya Paritosh , Sundar Shyam , Ritmeijer Koert , Stepniewska Kasia , Pandey Krishna , Guérin Philippe J , Musa Ahmed 
Published: December 2023

IntroductionVisceral leishmaniasis (VL) is a parasitic disease with an estimated 30 000 new cases occurring annually. Despite anaemia being a common haematological manifestation of VL, the evolution of different haematological characteristics following treatment remains poorly understood. An individual participant data meta-analysis (IPD-MA) is planned to characterise the haematological dynamics in patients with VL.Methods and analysisThe Infectious Diseases Data Observatory (IDDO) VL data platform is a global repository of IPD from therapeutic studies identified through a systematic search of published literature (PROSPERO registration: CRD42021284622). The platform currently holds datasets from clinical trials standardised to a common data format. Corresponding authors and principal investigators of the studies indexed in the IDDO VL data platform meeting the eligibility criteria for inclusion were invited to be part of the collaborative IPD-MA. Mixed-effects multivariable regression models will be constructed to identify determinants of haematological parameters by taking clustering within study sites into account.Ethics and disseminationThis IPD-MA meets the criteria for waiver of ethical review as defined by the Oxford Tropical Research Ethics Committee (OxTREC) granted to IDDO, as the research consists of secondary analysis of existing anonymised data (exempt granted on 29 March 2023, OxTREC REF: IDDO). Ethics approval was granted by the ICMR-Rajendra Memorial Research Institute of Medical Sciences ethics committee (letter no.: RMRI/EC/30/2022) on 4 July 2022. The results of this analysis will be disseminated at conferences, the IDDO website and peer-reviewed publications in open-access journals. The findings of this research will be critically important for control programmes at regional and global levels, policymakers and groups developing new VL treatments.PROSPERO registration numberCRD42021284622.
Perceptions of academic staff and students of senior high school in implementing game-based exercises in physical education classes—a research protocol for a qualitative descriptive study
Authors: Manlapaz Donald , Vergara Jose Avelino , Alpuerto Keisha Marie Bea , De Los Santos Iszaac Khalil Señora , Enriquez Michaela Urian , Manicio Zamantha Zamora , Mendres Joshua Emmanuel Ferrera , Tolosa Casey Gwyn Salvaleon , Vilela Zachary Gabriel Dee , Zabat Zeraia Ezra Gabriel Alonzo 
Published: December 2023

BackgroundThe COVID-19 pandemic has taken a toll on both physical activity and fitness as several pursuits and activities have been restricted. Coupled with this, increased food intake and sedentary lifestyles have produced poor physical health outcomes. Online physical education classes have been more difficult to conduct given the limitations of the setup. As such, exergaming has been identified as a possible educational tool that could improve students’ motivation, participation and fitness levels and reduce negative behaviours in class while contributing to the current curriculum.ObjectivesThe study explores the perspectives of both the physical education academic staff and senior high school students from the University of Santo Tomas on the implementation of exergaming to determine the feasibility of exergaming as an educational tool in the Philippines’ physical education curriculum.MethodologyA descriptive qualitative design will be used and participants will be selected through criterion sampling. The authors will conduct a process of question development and pilot FGDs beforehand to ensure smooth proceedings. Once done, they will undergo FGDs conducted through Google Meet. Data will be coded and analysed via thematic analysis using manual coding and NVivo V.12 software to summarise central themes and perceptions.Ethics and disseminationThis study will abide by the Nuremberg Code, Declaration of Helsinki, Belmont Report, Data Privacy Act of 2012 and National Ethical Guidelines (for health-related research) of 2017. The study has received approval from the University of Santo Tomas (UST)-College of Rehabilitation Sciences (CRS) Ethics Review Committee. All participant data will be labelled according to random two-digit computer generated codes to preserve anonymity and stored in password-protected laptops and Google Drive folders to preserve confidentiality. Results will be made available to individual UST physical education academic staff and senior high school students prior to publication in peer-reviewed journal.
Development and validation of a risk prediction model for pulmonary tuberculosis among presumptive tuberculosis cases in Ethiopia
Authors: Wolde Haileab Fekadu , Clements Archie C A , Alene Kefyalew Addis 
Published: December 2023

BackgroundEarly diagnosis and treatment of tuberculosis (TB) is one of the key strategies to achieve the WHO End TB targets. This study aimed to develop and validate a simple, convenient risk score to diagnose pulmonary TB among presumptive TB cases.MethodsThis prediction model used Ethiopian national TB prevalence survey data and included 5459 presumptive TB cases from all regions of Ethiopia. Logistic regression was used to determine which variables are predictive of pulmonary TB. A risk prediction model was developed, incorporating significant variables (p<0.05). The Youden Index method was used to choose the optimal cut-off point to separate the risk score of the patients as high and low. Model performance was assessed using discrimination power and calibration. Internal validation of the model was assessed using Efron’s enhanced bootstrap method, and the clinical utility of the risk score was assessed using decision curve analysis.ResultsOf total participants, 94 (1.7%) were confirmed to have TB. The final prediction model included three factors with different scores: (1) TB contact history, (2) chest X-ray (CXR) abnormality and (3) two or more symptoms of TB. The optimal cut-off point for the risk score was 6 and was found to have a good discrimination accuracy (c-statistic=0.70, 95% CI: 0.65 to 0.75). The risk score has sensitivity of 51.1%, specificity of 79.9%, positive predictive value of 4.3% and negative predictive value of 98.9%. After internal validation, the optimism coefficient was 0.003, which indicates the model is internally valid.ConclusionWe developed a risk score that combines TB contact, number of TB symptoms and CXR abnormality to estimate individual risk of pulmonary TB among presumptive TB cases. Though the score is easy to calculate and internally validated, it needs external validation before widespread implementation in a new setting.
Effectiveness of transcranial direct current stimulation (tDCS) as adjunctive treatment for chronic headache in adults with clinically stable systemic lupus erythematosus (SHADE): a randomised double-blind multiarm sham controlled clinical trial
Authors: Estiasari Riwanti , Tiksnadi Amanda , Tunjungsari Dyah , Maharani Kartika , Aninditha Tiara , Sofyan Henry Riyanto , Savitri Irma , Pangeran David , Jeremia Ivan , Widhani Alvina , Ariane Anna 
Published: December 2023

BackgroundChronic headache is a ‘silent’ neuropsychiatric systemic lupus erythematosus symptom with heterogeneous prevalence, potentially reaching 54.4%. It may reduce quality of life by increasing the likelihood of depression and sleep disturbance. While pharmacotherapy remains the first-line treatment, the current management is still challenging and needs other non-invasive modalities. An effective, tolerable and disease-specific treatment modality including transcranial direct current stimulation (tDCS) is considered to reduce the frequency of chronic headaches, including in SLE. Until recently, there was no standard protocol for tDCS in treating headaches.Methods and analysisSHADE is a single-centre randomised double-blind multiarm sham-controlled trial for adults with clinically stable SLE, chronic headaches and without history of traumatic brain injury, brain infection, stroke or brain tumour. Random allocation is conducted to 88 subjects into 3 treatment groups (administration at primary motor, primary sensory and dorsolateral prefrontal cortex) and control group in 1:1:1:1 ratio. The primary endpoint is reduced number of headache days after adjunctive tDCS. The secondary endpoints are reduced headache intensity, increased quality of life, increased sleep quality, decreased depression and reduced analgesics use. The outcome is measured monthly until 3-month postintervention using headache diary, 36-Item Short Form Survey, Chronic Headache Quality of Life Questionnaire, Pittsburgh Sleep Quality Index and Mini International Neuropsychiatry Interview version 10 (MINI ICD 10). Intention-to-treat analysis will be performed to determine the best tDCS electrode placement.Ethics and disseminationEthical approval had been obtained from the local Institutional Review Board of Faculty of Medicine Universitas Indonesia. Results will be published through scientific relevant peer-reviewed journals.Trial registration numberNCT05613582.
Non-specific effects of Pneumococcal and Haemophilus vaccines in children aged 5 years and under: a systematic review
Authors: Geraghty Keith , Rooney Darragh , Watson Chris , Ledwidge Mark T , Glynn Liam , Gallagher Joe 
Published: December 2023

ObjectiveTo determine the evidence for non-specific effects of the Pneumococcal and Haemophilus influenza vaccine in children aged 5 years and under.Data sourcesA key word literature search of MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials, the European Union Clinical Trials Register and ClinicalTrials.gov up to June 2023.Study eligibility criteriaRandomised controlled trials (RCTs), quasi-RCT or cohort studies.ParticipantsChildren aged 5 or under.Study appraisal and synthesis methodsStudies were independently screened by two reviewers, with a third where disagreement arose. Risk of bias assessment was performed by one reviewer and confirmed by a second. Results were tabulated and a narrative description performed.ResultsFour articles were identified and included in this review. We found a reduction in hospitalisations from influenza A (44%), pulmonary tuberculosis (42%), metapneumovirus (45%), parainfluenza virus type 1–3 (44%), along with reductions in mortality associated with pneumococcal vaccine. No data on the Haemophilus vaccine was found.Conclusions and implicationsIn this systematic review, we demonstrate that there is a reduction in particular viral infections in children aged 5 years and under who received the 9-valent pneumococcal conjugate vaccine which differ from those for which the vaccine was designed to protect against. While limited studies have demonstrated a reduction in infections other than those which the vaccine was designed to protect against, substantial clinical trials are required to solidify these findings.PROSPERO registration numberCRD42020146640.
Health outcomes in those who have been victims of knife crime: a protocol for a systematic review and meta-analysis
Authors: Gani Illin , Chandan Joht Singh , Bandyopadhyay Siddhartha , Pathmanathan Anna , Martin James 
Published: December 2023

IntroductionKnife-enabled crime is a UK public health issue leading to substantial impacts on society, victims and their families, as well as additional strain on the healthcare system. Despite the increase in knife-enabled crime and the overwhelming consequences, there is a lack of comprehensive studies exploring the long-term health outcomes of knife crime victims in the UK. The research gap hinders the development of more targeted secondary preventative interventions, resource allocation and public awareness campaigns. This systematic review aims to identify the long-term health outcomes of knife crime victims, therefore providing valuable knowledge for stakeholders, health practitioners and policymakers for a more effective public health response.Methods and analysisA comprehensive search strategy was developed, focusing on four key concepts: study design, knife-related offences, outcomes and risk. Databases being searched include MEDLINE, EMBASE, PsycINFO, ProQuest Criminology Collection, Web of Science Core Collection, Google Scholar and OpenGrey. Reference lists and forward citations will be inspected for further suitable literature. The study selection will involve two independent reviewers screening the studies from the search, with disagreements resolved by a third reviewer. All UK quantitative research on long-term health outcomes of knife crime victims will be included in the review. Covidence will be used to efficiently manage data. A data extraction form has been developed which will summarise key aspects of each study that will be included in the review. Methodological Index for Non-Randomised Studies quality assessment checklist will be used to assess the studies and the Newcastle-Ottawa Scale will assess the risk of bias in each study. Findings will be narratively synthesised, and if heterogeneity is sufficient, a meta-analysis will be conducted.Ethics and disseminationEthics approval is not required for this study as no original data will be collected. The results will be disseminated through a peer-reviewed publication and conference presentation.
Financial hardship for patients with cancer and caregivers at end of life in the USA: narrative review
Authors: Salazar Marisa Martinez , Khera Nandita , Chino Fumiko , Johnston Emily 
Published: December 2023

BackgroundPatients and their families face financial hardship during cancer treatment, which may intensify at end of life (EOL) due to increased symptoms and care needs. We undertook a narrative literature review to describe the current understanding of the causes, impacts and factors associated with financial hardship at EOL. We identify gaps in research, policy and clinical practice and propose steps to mitigate financial hardship for patients and caregivers at EOL.MethodsWe conducted a Medline search to identify US studies since 2000 that examined EOL financial hardship for patients with cancer and their caregivers.ResultsTwenty-seven adult and four paediatric studies met review criteria. Adults with cancer and their caregivers face significant financial hardship at EOL and in bereavement, especially due to employment changes and informal caregiving time costs. Financial hardship may be higher for younger caregivers and for patients who are uninsured, low income, rural, with high symptom burdens or with certain cancer types. The few paediatric studies showed high financial hardship and employment impact lasting well beyond a child’s death.ConclusionsThere is limited literature examining financial hardship at EOL in the USA, especially in paediatrics. Priorities for future research include longitudinal studies in diverse populations of patients with cancer and informal caregivers using standardised financial hardship measures. Policies to address financial hardship at EOL, especially with hospice care, should include insurance coverage for family caregiving and medical leave policies. There is need for increased financial hardship screening at EOL and in bereavement and a need for financial navigation interventions.
Similarity in evoked responses does not imply similarity in macroscopic network states
Authors: Rasero Javier , Betzel Richard , Sentis Amy Isabella , Kraynak Thomas E. , Gianaros Peter J. , Verstynen Timothy 
Published: December 2023

Abstract
It is commonplace in neuroscience to assume that if two tasks activate the same brain areas in the same way, then they are recruiting the same underlying networks. Yet computational theory has shown that the same pattern of activity can emerge from many different underlying network representations. Here we evaluated whether similarity in activation necessarily implies similarity in network architecture by comparing region-wise activation patterns and functional correlation profiles from a large sample of healthy subjects (N = 242). Participants performed two executive control tasks known to recruit nearly identical brain areas, the color-word Stroop task and the Multi-Source Interference Task (MSIT). Using a measure of instantaneous functional correlations, based on edge time series, we estimated the task-related networks that differed between incongruent and congruent conditions. We found that the two tasks were much more different in their network profiles than in their evoked activity patterns at different analytical levels, as well as for a wide range of methodological pipelines. Our results reject the notion that having the same activation patterns means two tasks engage the same underlying representations, suggesting that task representations should be independently evaluated at both node and edge (connectivity) levels.
Altered topological structure of the brain white matter in maltreated children through topological data analysis
Authors: Chung Moo K. , Azizi Tahmineh , Hanson Jamie L. , Alexander Andrew L. , Pollak Seth D. , Davidson Richard J. 
Published: December 2023

Abstract
Childhood maltreatment may adversely affect brain development and consequently influence behavioral, emotional, and psychological patterns during adulthood. In this study, we propose an analytical pipeline for modeling the altered topological structure of brain white matter in maltreated and typically developing children. We perform topological data analysis (TDA) to assess the alteration in the global topology of the brain white matter structural covariance network among children. We use persistent homology, an algebraic technique in TDA, to analyze topological features in the brain covariance networks constructed from structural magnetic resonance imaging and diffusion tensor imaging. We develop a novel framework for statistical inference based on the Wasserstein distance to assess the significance of the observed topological differences. Using these methods in comparing maltreated children with a typically developing control group, we find that maltreatment may increase homogeneity in white matter structures and thus induce higher correlations in the structural covariance; this is reflected in the topological profile. Our findings strongly suggest that TDA can be a valuable framework to model altered topological structures of the brain. The MATLAB codes and processed data used in this study can be found at https://github.com/laplcebeltrami/maltreated.
The Quality of Hasmonaean Biblical Manuscripts
Authors: Popović Mladen , Tigchelaar Eibert 
Published: December 2023

Abstract
Recent research has introduced the categories of deluxe or high-quality Dead Sea Scrolls. We reconsider this category and propose a classification of manuscripts on the basis of handwriting quality. As a test case, we classify all Hasmonaean-type biblical manuscripts as elegant, professional, or substandard. We discuss eleven scrolls with elegant handwriting and consider other physical, scribal, and textual features of these scrolls. Our study calls into question the idea that especially biblical manuscripts would have been copied according to the highest standards. We show that different quality standards were in operation for Hasmonaean-type biblical manuscripts.
First reports of inland water benthic crustaceans for a Mediterranean-climate river (Claro River basin, Chile)
Authors: De los Ríos-Escalante Patricio R. , Esse Carlos , Ulloa-Yáñez Alfredo , Santander-Massa Rodrigo , Peña-Farfal Carlos , Corsini Acuña Gino , Guerra Emilio , Correa-Araneda Francisco , Martin Juan 
Published: December 2023

Abstract
Existing studies on central Chilean inland waters only mention records of decapods, but there are no ecological studies about decapods and other crustacean groups. The aim of the present study was a first characterization of inland water crustaceans in Claro River, a Mediterranean-climate river from Chile. The results of redundance analysis (RDA) revealed that the crab Aegla affinis inhabits waters of high pH and low temperature values, whereas amphipods of the genus Hyalella inhabit habitats with high pH, high temperatures, and low values of dissolved oxygen. Finally, ostracods (family Cyprididae), isopods (Heterias sp.) and the southern river crayfish (Samastacus spinifrons) inhabit water systems with moderate values of pH, temperature, dissolved oxygen, and conductivity. This paper represents the first ecological report for crustaceans of central Chilean inland waters, and the results appear to be similar to comparable descriptions for northern Patagonian rivers.
Pinnotheres onychodactylus Tesch, 1918: a junior synonym of Magnotheres Globosus (Hombron & Jacquinot, 1846) (Decapoda, Brachyura, Pinnotheridae)
Authors: Ng Peter K. L. , Ahyong Shane T. 
Published: December 2023

Abstract
The pea crab, Pinnotheres onychodactylus Tesch, 1918, is only known on the basis of the types collected from the Moluccas, Indonesia. A re-examination of the type specimens shows that the species is actually a junior subjective synonym of Magnotheres globosus (Hombron & Jacquinot, 1846), a widely distributed Indo-West Pacific species associated with horse mussels of the family Pinnidae.
L’établissement de la mission méthodiste en Côte d’Ivoire (c. 1924-1940)
Authors: Miran-Guyon Marie 
Published: December 2023

Résumé
Cet article revisite l’histoire des débuts de la Mission méthodiste wesleyenne en Côte d’Ivoire coloniale, depuis les prémices de la présence protestante sur le sol ivoirien à la fin du XIXe siècle, puis en resserrant la focale sur la période d’après la tournée « héroïque » du pasteur Platt en 1924 – ayant permis une complète refondation de la mission – jusqu’à la transition des années 1940. La conversion ivoirienne au christianisme est l’œuvre du prophète William Wadé Harris, dont la mission prophétique en 1913-1914 révolutionna la société de la Basse-Côte. L’article interroge comment la mission méthodiste se fit l’héritière d’Harris, en entrant en concurrence avec des communautés prophétiques locales et la mission catholique des pères de la Société des missions africaines. L’article explore aussi les stratégies linguistiques et éducatives mises en œuvre par les missionnaires méthodistes pour aller à la rencontre d’Africains et d’Africaines qui tentèrent, par leur conversion religieuse, de se convertir aussi à une certaine modernité coloniale, en se frayant un chemin incertain d’émancipation sous la double contrainte d’un ordre colonial et d’un ordre missionnaire exogènes.
Enacting the Mythical through Architecture
Authors: Spellerberg Jonathan 
Published: December 2023

Abstract
The beginning of the Third Reich saw the construction of large architectural structures to host and aesthetically frame Nazi mass events. The significance of these buildings cannot be understood without the propaganda and mass performances that constituted their contemporary frame of reception. This article discusses the Gauforum project in Weimar, constructed from 1937 until 1944. Combining an analysis of common architecture-related propaganda tropes with an examination of architectural design and a reading of the ceremony of laying the first foundation stone, it shows how these elements performed the longed-for Volksgemeinschaft. By framing construction works as the expression of national achievement and an ongoing revolutionary renewal of the nation, Nazi-era architecture propaganda discursively primed the ground for interplay between the material arrangements of architecture and events that afforded an experience of the mythical spatiotemporality of the Volksgemeinschaft. In this way, Nazi architectural propaganda played an efficacious part in the politics of mass events.