bluuebunny/crossref_metadata_2025_split huggingface dataset:
Best practices and lessons learned from implementing a massive Ebola vaccination program: Summarizing UMURINZI team experience
Authors: Dine Roseline Dzekem , Umutoni Aline Uwizera , Umulisa Marie Michele , Ezeanochie Nnamdi , Noben Jozef , Indoe Ellen Pagan , Dusingize Clémence , Kamali Fulgence , Niyingabira Julien 
Published: October 2023

AbstractBackground and AimsThe unified Rwandan initiative for national ZEBOVAC immunization (UMURINZI) program's community engagement component was enacted to mobilize and vaccinate high‐risk community members. This article describes best practices and lessons learned from the implementation of UMURINZI, a large‐scale Ebola vaccination program.MethodsThe population deemed to be at risk for EVD consisted of people who frequently cross Rwanda and the Democratic Republic of Congo (DRC) borders including those coming from Kigali City, potential first responders who have not previously been vaccinated against EVD, as well as people who reside in high‐risk border‐proximate areas of the Rubavu and Rusizi districts in the Western Province of Rwanda. These districts were selected because of their proximity to high‐traffic borders linking Rwanda to DRC's cities near an active Ebola outbreak. Volunteers of this program were adults, adolescents, and children aged 2 years or above who resided in the selected communities. Recruitment at the sites was conducted in close collaboration with each health area's Community Health Workers (CHWs). Volunteers were informed that the program involved being fully vaccinated (two doses of Ebola vaccines) within 2 months apart in the allocated vaccination sites.ResultsLessons learned were categorized into four pillars: infrastructure, leadership, myths, and partnership with respect. The best practices that were used during the implementation of the UMURINZI program were the results of a collaboration among CHWs, the involvement of national and local leaders, the use of a comprehensive engagement plan, and training. The study also had limitations.ConclusionWe described best practices and lessons learned during the implementation of the UMURINZI program in Rwanda. These practices and lessons learned represent promising options that could contribute to better community members' participation in mass vaccination programs. Hence, we demonstrated that rigorously designed community awareness and sensitization programs are effective for the implementation of similar programs in resource‐limited settings.
Synthesis and characterization of imidazo[1,2‐d][1,2,4]oxadiazole‐functionalized furazan energetic compounds
Authors: Chen Peng , Dou Hui , Liu Suyun , He Chunlin 
Published: October 2023

AbstractTwo novel oxygen‐containing imidazo[1,2‐d][1,2,4]oxadiazole heterocycle compounds 2 and 3 were successfully synthesized by oxidation of the aminofurazan group. Compounds 2 and 3 were fully characterized by Fourier Transform Infrared, multinuclear NMR spectroscopy, elemental analysis, and single‐crystal X‐ray diffraction. Their properties were evaluated by measured density, impact, and friction sensitivities, calculated heat of formation, and detonation performances. Compound 2 has high density (1.87 g cm−3), good detonation velocity and pressure (D:8690 m s−1, P: 33.3 GPa), acceptable sensitivity (IS: 12 J, FS: 144 N), and its overall performance is comparable to RDX. Compound 3 has a better sensitivity (IS: 28 J, FS: 252 N), but the detonation performance is average (D:8008 m s−1, P: 27.4 GPa), which may be caused by its low packing index (70.9%) affecting its density (1.78 g cm−3).
Graphene‐Based Engineered Living Materials
Authors: Allahbakhsh Ahmad , Gadegaard Nikolaj , Ruiz Carmen M. , Shavandi Amin 
Published: October 2023

AbstractWith the rise of engineered living materials (ELMs) as innovative, sustainable and smart systems for diverse engineering and biological applications, global interest in advancing ELMs is on the rise. Graphene‐based nanostructures can serve as effective tools to fabricate ELMs. By using graphene‐based materials as building units and microorganisms as the designers of the end materials, next‐generation ELMs can be engineered with the structural properties of graphene‐based materials and the inherent properties of the microorganisms. However, some challenges need to be addressed to fully take advantage of graphene‐based nanostructures for the design of next‐generation ELMs. This work covers the latest advances in the fabrication and application of graphene‐based ELMs. Fabrication strategies of graphene‐based ELMs are first categorized, followed by a systematic investigation of the advantages and disadvantages within each category. Next, the potential applications of graphene‐based ELMs are covered. Moreover, the challenges associated with fabrication of next‐generation graphene‐based ELMs are identified and discussed. Based on a comprehensive overview of the literature, the primary challenge limiting the integration of graphene‐based nanostructures in ELMs is nanotoxicity arising from synthetic and structural parameters. Finally, we present possible design principles to potentially address these challenges.
Temporal associations between treated and untreated hearing loss and mild behavioral impairment in older adults without dementia
Authors: Gosselin Penny , Guan Dylan X. , Smith Eric E. , Ismail Zahinoor 
Published: October 2023

AbstractINTRODUCTIONHearing loss (HL) and mild behavioral impairment (MBI) are non‐cognitive markers of dementia. This study investigated the relationship between hearing and MBI and explored the influence of hearing aid use on the treatment of hearing loss, both cross‐sectionally and longitudinally.METHODSData were analyzed from National Alzheimer's Coordinating Center participants, age ≥50, dementia‐free at baseline, collected between 2005 and 2022. Three self‐report questions were used to generate a three‐level categorical hearing variable: No‐HL, Untreated‐HL, and Treated‐HL. MBI status was derived from the informant‐rated Neuropsychiatric Inventory Questionnaire (NPI‐Q) using a published algorithm. At baseline (n = 7080), logistic regression was used to examine the association between hearing status (predictor) and the presence of global and domain‐specific MBI (outcome), adjusting for age, sex, cognitive diagnosis, and apolipoprotein E4 (APOE4). Cox proportional hazard models with time‐dependent covariates were used to examine the effect of (1) hearing status as exposure on the rate of incident MBI (n = 5889); and (2) MBI as exposure on the rate of incident HL in those with no HL at baseline (n = 6252).RESULTSCross‐sectionally, participants with Untreated‐HL were more likely to exhibit global MBI (adjusted odds ratio (aOR) = 1.66, 95% CI: 1.24–2.21) and individual MBI domains of social inappropriateness (aOR = 1.95, 95% CI: 1.06–3.39), affective dysregulation (aOR = 1.71, 95% CI: 1.21–2.38), and impulse dyscontrol (aOR = 1.71, 95% CI: 1.21–2.38), compared to those with No‐HL. Participants with Treated‐HL (i.e., hearing aid use) did not differ from No‐HL for odds of global or most MBI domains, except for impulse dyscontrol (aOR = 1.38, 95% CI: 1.05–1.81). Longitudinally, we found relationships between Treated‐HL and incident MBI (adjusted hazard ratio (aHR) = 1.29, 95% CI: 1.01–1.63) and between MBI and incident Untreated‐HL (aHR = 1.51, 95% CI: 1.19–1.94).DISCUSSIONOur cross‐sectional results support that hearing aid use is associated with lower odds of concurrent global MBI in dementia‐free participants. Longitudinally, relationships were found between MBI and HL. The severity of HL was not assessed, however, and may require further exploration.Highlights
Hearing Loss (HL) and mild behavioral impairment (MBI) are markers of dementia
Cross‐sectionally: Untreated‐HL was associated with global MBI burden, but
HL treated with hearing aids was not
We found associations between MBI and incident Untreated‐HL
Analysis and Quality Control of WHO- and UNEP-Coordinated Human Milk Studies 2000–2019: Polychlorinated Biphenyls, Polychlorinated Dibenzo-p-dioxins, and Polychlorinated Dibenzofurans
Authors: Malisch Rainer , Schächtele Alexander 
Published: October 2023

AbstractThe analytical method used for the determination of polychlorinated biphenyls (PCB), polychlorinated dibenzo-p-dioxins (PCDD), and polychlorinated dibenzofurans (PCDF) in human milk comprised extraction of lipids, the use of 5113C12-labelled PCB and PCDD/PCDF as internal standards, several chromatographic purification steps, and high resolution gas chromatographic/high resolution mass spectrometric measurement. As an accredited laboratory since 1998, a comprehensive quality control programme has been applied to assure the long-time reliability of results of human milk samples received for WHO/UNEP-coordinated exposure studies between 2000 and 2019. This included procedural blanks, the use of fortified vegetable oil and numerous quality control samples as an in-house reference material, duplicate analyses, and successful participation in 32 proficiency tests (PTs) covering 81 samples of food of animal origin or human milk. Trueness was estimated from the PT samples in the relevant range for human milk above 1 pg WHO-TEQ/g lipid: The deviation was less than 10% from the assigned values for WHO-PCDD/PCDF-PCB-TEQ and WHO-PCDD/PCDF-TEQ and less than about 15% for WHO-PCB-TEQ for about 90% of the results. For the sum of six non-dioxin-like PCB (relevant occurrence range, 1–1000 ng/g lipid), approximately 90% of the results differed by less than 15% from the assigned values. A long-term precision of <15% (coefficient of variation of within-laboratory reproducibility) was achieved, based on quality control samples analysed between 2000 and 2019.The analytical methodology used fulfilled the requirements of the general criteria for the operation of testing laboratories as laid down in EN ISO/IEC 17025, the analytical criteria for PCDD/PCDF and PCB in feed and food specified in EU legislation, and the criterion for monitoring information for Parties to the Stockholm Convention.
Conceptualization and Sense of Reality of Some New, Legal Models for Conducting an Enterprise
Authors: Byttebier Koen 
Published: October 2023

AbstractBefore discussing in the next Sect. 7.2 (amongst others, in light of the newly proposed NMWO that has been discussed in Chap. 6), possible alternative models of conducting an enterprise than those that prevail under capitalism, it is useful to first undertake a deeper analysis of the basic principles that govern capitalist business conduct.
Komplizierter Verlauf einer medianen Halszyste
Authors: Flockerzi Veronika , Rink Katharina , Stahl Phillip Rolf , Schöndorf Dominik , Zemlin Michael , Schick Bernhard 
Published: October 2023

ZusammenfassungMediane Halszysten sind die zweithäufigste Ursache kindlicher Halsschwellungen. Es handelt sich um angeborene Relikte des Ductus thyreoglossus. Zügig nach der Diagnosestellung, die auf klinischer Untersuchung und sonographischer Beurteilung fußt, sollte die operative Resektion geplant werden, um komplizierte Verläufe beispielsweise durch Superinfektionen zu vermeiden. Mediane Halsfisteln entstehen sekundär aus medianen Halszysten, entweder durch Spontanperforation bei Entzündungen oder iatrogen. Von infektionsbedingten Spontanperforationen, die nur in etwa 11 % aller Fälle beobachtet werden, sind hauptsächlich Patienten in den ersten drei Lebensjahren betroffen. Im Fall einer akuten Superinfektion wird eine antibiotische Behandlung und nach Abklingen der Infektion die zeitnahe operative Resektion empfohlen.
Evaluation of the image quality and validity of handheld echocardiography for stroke volume and left ventricular ejection fraction quantification: a method comparison study
Authors: de Raat Frederique M. , van Houte Joris , Montenij Leon. J. , Bouwmeester Sjoerd , Felix Suzanne E. A. , Bingley Peter , de Boer Esmée C. , Houthuizen Patrick , Bouwman Arthur R. 
Published: October 2023

AbstractBedside quantification of stroke volume (SV) and left ventricular ejection fraction (LVEF) is valuable in hemodynamically compromised patients. Miniaturized handheld ultrasound (HAND) devices are now available for clinical use. However, the performance level of HAND devices for quantified cardiac assessment is yet unknown. The aim of this study was to compare the validity of HAND measurements with standard echocardiography (SE) and three-dimensional echocardiography (3DE). Thirty-six patients were scanned with HAND, SE and 3DE. LVEF and SV quantification was done with automated software for the HAND, SE and 3DE dataset. The image quality of HAND and SE was evaluated by scoring segmental endocardial border delineation (2 = good, 1 = poor, 0 = invisible). LVEF and SV of HAND was evaluated against SE and 3DE using correlation and Bland–Altman analysis. The correlation, bias, and limits of agreement (LOA) between HAND and SE were 0.68 [0.46:0.83], 1.60% [− 2.18:5.38], and 8.84% [− 9.79:12.99] for LVEF, and 0.91 [0.84:0.96], 1.32 ml [− 0.36:4.01], 15.54 ml [− 18.70:21.35] for SV, respectively. Correlation, bias, and LOA between HAND and 3DE were 0.55 [0.6:0.74], − 0.56% [− 2.27:1.1], and 9.88% [− 13.29:12.17] for LVEF, and 0.79 [0.62:0.89], 6.78 ml [2.34:11.21], 12.14 ml [− 26.32:39.87] for SV, respectively. The image quality scores were 9.42 ± 2.0 for the apical four chamber views of the HAND dataset and 10.49 ± 1.7 for the SE dataset and (P < 0.001). Clinically acceptable accuracy, precision, and image quality was demonstrated for HAND measurements compared to SE. In comparison to 3DE, HAND showed a clinically acceptable accuracy and precision for LVEF quantification.
Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies
Authors: Giunta Sergio , Xia Shijin , Pelliccioni Giuseppe , Olivieri Fabiola 
Published: October 2023

AbstractInflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting subclinical, proinflammatory status, currently recognized as the main risk factor for development and progression of the most common age-related diseases (ARDs). Extensive investigations were focused on a plethora of proinflammatory stimuli that can fuel inflammaging, underestimating and partly neglecting important endogenous anti-inflammaging mechanisms that could play a crucial role in such age-related proinflammatory state. Studies on autonomic nervous system (ANS) functions during aging highlighted an imbalance toward an overactive sympathetic nervous system (SNS) tone, promoting proinflammatory conditions, and a diminished parasympathetic nervous system (PNS) activity, playing anti-inflammatory effects mediated by the so called cholinergic anti-inflammatory pathway (CAP). At the molecular level, CAP is characterized by signals communicated via the vagus nerve (with the possible involvement of the splenic nerves) through acetylcholine release to downregulate the inflammatory actions of macrophages, key players of inflammaging. Notably, decreased vagal function and increased burden of activated/senescent macrophages (macrophaging) probably precede the development of several age-related risk factors and diseases, while increased vagal function and reduced macrophaging could be associated with relevant reduction of risk profiles. Hypothalamic–pituitary–adrenal axis (HPA axis) is another pathway related to ANS promoting some anti-inflammatory response mainly through increased cortisol levels. In this perspective review, we highlighted that CAP and HPA, representing broadly “anti-inflammaging” mechanisms, have a reduced efficacy and lose effectiveness in aged people, a phenomenon that could contribute to fuel inflammaging. In this framework, strategies aimed to re-balance PNS/SNS activities could be explored to modulate systemic inflammaging especially at an early subclinical stage, thus increasing the chances to reach the extreme limit of human lifespan in healthy status.
Sinn als Grundbegriff der Managementlehre. Die Neuerfindung organisationaler Beweglichkeit durch New Work, Purpose und Humanocracy
Authors: Wendt Thomas 
Published: October 2023

ZusammenfassungDer Beitrag der Zeitschrift „Gruppe. Interaktion. Organisation (GIO)“ analysiert die aktuelle Sinn- und Subjektorientierung im Management als historische Konsequenz gescheiterter Steuerungsversuche und rekonstruiert eine Kontinuitätslinie der zunehmenden Verabschiedung organisationaler Verhaltenserwartungen und Handlungsimperative. Die Archäologie der Managementlehre zeigt einen Wandel im managerialen Steuerungsverständnis auf und macht sichtbar, dass die Geschichte des Managements von Rationalitätskritiken der Organisation begleitet wird, die sich im Rahmen agiler Methoden wie Design Thinking, Scrum oder Holacracy erneuert. Als Reaktion darauf erfolgt durch die Betonung von Sinn und Selbstorganisation in Konzepten wie New Work, Purpose oder Humanocracy ein grundlegender Richtungswechsel im Management. An die Stelle statischer wie dynamischer Ordnungsprinzipien tritt das sinn- und willensbildende Potenzial des Subjekts, um die Beweglichkeit der Organisation zu sichern. Gleichzeitig stellt sich damit die Frage, ob die Geschichte der Managementlehre im Modus der Bewirtschaftung individueller Identitäten einen Neuanfang nimmt oder ihr logisches Ende erreicht hat.
Erythromelalgie: Calor – Rubor – Dolor – einmal ganz anders
Authors: Decker C. , Baldauf I. , Maier H. 
Published: October 2023

ZusammenfassungErythromelalgie ist eine Erkrankung, bei der es anfallsartig zu brennenden Schmerzen, Rötung, Überwärmung und auch Schwellung insbesondere an den Extremitäten kommt. Unterschieden wird zwischen einer primären und einer sekundären Form der Krankheit. Die Diagnose wird klinisch gestellt. Da es sich bei der Erythromelalgie um eine sehr seltene Erkrankung handelt, gibt es derzeit keine etablierte Therapie. Wie auch bei unserer Patientin zu sehen ist, wurden zahlreiche Therapieansätze versucht, jedoch leider ohne dauerhaften Erfolg.
Attenuation of Hyperglycemia in Diabetic Rats Assisted by Immobilized Probiotic in Sodium Alginate
Authors: Arriaga-Morales José J. , Ordaz-Pichardo Cynthia , Castro‑Muñoz Roberto , Durán-Páramo Enrique 
Published: October 2023

AbstractDiabetes mellitus type 2 (DM2) is the most common chronic disease worldwide, characterized mainly by increased glucose concentration in the blood and affecting several organs’ functionality. The daily consumption of probiotic bacteria can help control diabetes and reduce the damage caused. Cell immobilization techniques are a powerful tool that provides physical cell protection to such probiotic bacteria against gastrointestinal conditions. We suggest that cell immobilization could be a significant vector for delivering a high quantity of viable probiotics to the gut, helping attenuate hyperglycemia in diabetic rats. Seventy male Wistar rats were used in this work. Nicotinamide was administrated via intraperitoneal injection 15 minutes before inducing type 2 diabetes (DM2), followed by a second intraperitoneal injection of streptozotocin to induce DM2. Rats were divided into seven groups. For 45 days, a specific treatment was applied to each group. The group of rats, supplied with immobilized Lactobacillus casei, showed a serum glucose concentration of 137 mg/dL, which was close to the one observed in the groups of healthy rats (117 mg/dL) and rats treated with metformin (155 mg/dL). The diabetic rats without treatment presented a higher serum glucose concentration (461 mg/dL). In the rats treated with immobilized L. casei, there was no biochemical parameter alteration, and the cell morphology of the analyzed tissues was similar to those of the healthy group. The consumption of immobilized L. casei could allow a high quantity of viable probiotics to be delivered to the gut, reducing serum glucose concentration by up to 70% compared to diabetic rats and reducing organ damage caused by diabetes.
Accelerating Large Table Scan Using Processing-In-Memory Technology
Authors: Baumstark Alexander , Jibril Muhammad Attahir , Sattler Kai-Uwe 
Published: October 2023

AbstractToday’s systems are capable of storing large amounts of data in main memory. Particularly, in-memory DBMSs benefit from this development. However, the processing of data from the main memory necessarily has to run via the CPU. This creates a bottleneck, which affects the possible performance of the DBMS. Processing-In-Memory (PIM) is a paradigm to overcome this problem, which was not available in commercial systems for a long time. With the availability of UPMEM, a commercial product is finally available that provides PIM technology in hardware. In this work, we focus on the acceleration of the table scan, a fundamental database query operation. We show and investigate an approach that can be used to optimize this operation by using PIM. We evaluate the PIM scan in terms of parallelism and execution time in benchmarks with different table sizes and compare it to a traditional CPU-based table scan. The result is a PIM table scan that outperforms the CPU-based scan significantly.
Locating community smells in software development processes using higher-order network centralities
Authors: Gote Christoph , Perri Vincenzo , Zingg Christian , Casiraghi Giona , Arzig Carsten , von Gernler Alexander , Schweitzer Frank , Scholtes Ingo 
Published: October 2023

AbstractCommunity smells are negative patterns in software development teams’ interactions that impede their ability to successfully create software. Examples are team members working in isolation, lack of communication and collaboration across departments or sub-teams, or areas of the codebase where only a few team members can work on. Current approaches aim to detect community smells by analysing static network representations of software teams’ interaction structures. In doing so, they are insufficient to locate community smells within development processes. Extending beyond the capabilities of traditional social network analysis, we show that higher-order network models provide a robust means of revealing such hidden patterns and complex relationships. To this end, we develop a set of centrality measures based on the higher-order network model and show their effectiveness in predicting influential nodes using five empirical datasets. We then employ these measures for a comprehensive analysis of a product team at the German IT security company genua GmbH, showcasing our method’s success in identifying and locating community smells. Specifically, we uncover critical community smells in two areas of the team’s development process. Semi-structured interviews with five team members validate our findings: while the team was aware of one community smell and employed measures to address it, it was not aware of the second. This highlights the potential of our approach as a robust tool for identifying and addressing community smells in software development teams. More generally, our work contributes to the social network analysis field with a powerful set of higher-order network centralities that effectively capture community dynamics and indirect relationships.