bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and investigation of antibacterial activity of 1-(4-substituted phenyl)-5-oxopyrrolidine-3-carbohydrazide derivatives
Authors: Plaga Aurimas , Sapijanskaitė-Banevič Birutė , Vaickelionienė Rita 
Published: December 2023

Hydrazides are very important precursors for the synthesis of a wide variety of derivatives, including heterocyclic compounds of biological interest in drug design and discovery. Acid hydrazides with a pyrrole, thiophene, furan, quinoline, isoquinoline, isoxazole and benzimidazole core in the structure were found to be used in medicine, pharmacy, agriculture and many other fields.
In the search for compounds with antibacterial properties, mono- and dihydrazides were used in this study to prepare 1-(4-substituted phenyl)-5-oxopyr-rolidine-3-carbohydrazide derivatives bearing the corresponding hydrazone and azole substituents.
The formation of the target compounds was performed via condensation reactions with the chosen aromatic aldehydes and isatin, which led to the construction of the appropriate hydrazone-type structures as well as with diketones which afforded compounds with pyrazole and pyrrole nuclei.
In addition, a preliminary antibacterial evaluation of the synthesised compounds was performed using the gram-positive Bacillus subtilis and the gramnegative Escherichia coli bacterial strains. As it was expected, the evaluation revealed potential antibacterial candidates that can help address the global challenges of antibiotic resistance and infectious disease outbreaks.
ANALISIS SWOT UNTUK MENENTUKAN STRATEGI BISNIS UMKM KERUPUK AZIZAH
Authors: Suri Puti Anggun , Feranisa Rani , Maulana Reksa , Afifah Rifa , Putra Ramdani Bayu 
Published: December 2023

Usaha Mikro, Kecil, dan Menengah (UMKM) merupakan sektor penting dalam perekonomian salah satu jenisnya adalah UMKM kerupuk azizah. Kerupuk azizah merupakan makanan ringan yang memiliki pasar yang luas dan permintaan yang tinggi di masyarakat. Abstrak ini membahas tentang UMKM kerupuk azizah, meliputi aspek-aspek penting terkait produksi, pemasaran, dan tantangan yang dihadapi. UMKM kerupuk azizah dimulai dengan skala kecil, produksi yang dilakukan di rumah dengan fasilitas sederhana. Bahan baku utama untuk kerupuk bawang adalah tepung tapioka, tepung terigu, dan bahan tambahan lainnya seperti bawang putih, bawang merah, dan cabe. Proses produksi melibatkan pencampuran bahan-bahan, pembentukan adonan, penggilingan, dan penggorengan. Dalam pemasaran, UMKM kerupuk azizah umumnya mengandalkan saluran distribusi lokal, seperti toko-toko, pasar tradisional, atau luar sumbar. Namun, dengan perkembangan teknologi informasi dan internet, banyak UMKM kerupuk azizah juga mulai memanfaatkan platform online untuk memperluas jangkauan pasar mereka. Melalui media sosial, shoppe, facebook, atau tokopedia. mereka dapat mencapai konsumen di berbagai daerah dan bahkan di luar negeri. Namun, UMKM kerupuk azizah juga menghadapi beberapa tantangan. Salah satunya adalah persaingan dalam produk, persaingan timbul karna tingginya permintaan dan pasar yang luas. Selain itu, para pesaing kerupuk azizah yang sama bergerak dibidang pembuatan kerupuk bawang dan kue lainnya memberikan harga yang lebih murah unuk produk yang sejenis. Dalam kesimpulan, UMKM kerupuk azizah memiliki peran yang signifikan dalam perekonomian dengan menyediakan lapangan kerja dan kontribusi terhadap pertumbuhan ekonomi. Namun, mereka dihadapkan pada berbagai tantangan yang perlu diatasi.
Dengan adanya upaya peningkatan kualitas, pemasaran yang efektif, dan dukungan dari berbagai pihak, UMKM kerupuk azizah dapat terus berkembang dan memberikan manfaat yang lebih besar bagi pemilik usaha dan masyarakat secara umum.
An Explainable Content-Based Course Recommender Using Job Skills
Authors: Younus Yasir Mahmood 
Published: December 2023

The large number of courses offered in universities and online studies made it difficult for students to choose the courses that suit their interests and career goals, which led students to lose many opportunities to be employed in the job they wanted. To keep pace with the rapid development of technology, and instead of relying on the job title as was previously done, the employers began to identify the skills required for a job. The competencies of the candidates are then examined and evaluated according to those requirements. Thus, it has become necessary for students to take courses that suit their future professional interests, ensuring that they are employed in the job they desire and supporting their long-term career success. Fortunately, the emergence of skills-based employment has provided an opportunity for universities and colleges to create a clearer path to the courses offered to allow students to take courses that match their future career interests. In this study, we used K-Mean clustering algorithm, TF-idf approach, and content-based filtering algorithm to provide relevant courses for students based on the required job with an explanation of why these courses are recommended. Our result illustrates that our method offers many advantages compared with other recommender systems. our system converts a simple course recommendation into a tool for discovering skills. Since many recommendation systems work as black boxes, we designed our system to recommend the relevant course with explaining why these courses are recommended, which will add a factor of transparency to our system and confirms the reliability of the system to the students.
PARÂMETROS PROJETUAIS PARA O PROJETO ARQUITETÔNICO DE UMA EDIFICAÇÃO MAIS SUSTENTÁVEL
Authors: De Andrade Edivanete Márcia Nogueira 
Published: December 2023

O objetivo deste artigo é apresentar parâmetros mais sustentáveis aplicados à fase de concepção do projeto de arquitetura, tendo em vista a situação de degradação ambiental causada pelas obras civis no que se refere à própria construção, ocupação e manutenção. Estes efeitos podem ser minimizados com diretrizes projetuais relativamente simples, mas que devem nascer com o projeto. Para elencar os parâmetros baseou-se em pesquisas bibliográficas, quase que exclusivamente nacionais, dividindo as diretrizes projetuais em cinco grupos: localização e implantação, conforto térmico e lumínico, energia, água e resíduos. Observa-se que as diretrizes podem ser aplicadas em diversas subáreas da construção civil, de forma holística e sistêmica, pois soluções apresentadas no projeto de arquitetura podem e vão influenciar projetos de outras engenharias, como elétrica, hidrossanitária e vice-versa. É válido salientar que há inúmeras soluções técnicas possíveis para o mesmo problema, e aqui não se espera apresentar todas essas soluções, e sim introduzir, dentro de cada grupo, além da problematização, a exemplificação de soluções que buscam uma edificação mais sustentável.
DEVELOPMENT OF MOROTAI ISLAND TOURISM DESTINATIONS, A TROPICAL PARADISE IN NORTH MALUKU PROVINCE
Authors: Watriningsih  , Meiliyah Ariani  , Zulhawati  
Published: December 2023

Morotai Island Regency as one of the tourist destinations that has the potential for natural and cultural tourism that has the potential to be developed into an attraction for tourist visits, both domestic and foreign tourists. The charm of Morotai Island is able to divert the eyes of tourists so that more tourists come to Morotai Island and enjoy the beautiful charm of amazing tourist objects, with the charm of natural tourism and strong historical tourism able to make Morotai Island one of the 4 favorite tourist attractions in North Maluku by foreign tourists and domestic tourists. The purpose of this study was conducted to describe the strategy of the concept of developing the promotion of Marine Tourism and Historical Tourism as a strengthening of Identity as a tropical paradise region to attract tourist visits to Morotai Regency, North Maluku Province. The concept of marine ecotourism as the right model for the development base of tourist objects and attractions owned by Morotai Island Regency. The development of historical tourism in Morotai Island Regency can be in line with strengthening the identity of Morotai Island Regency as an area that became part of the history of World War II, by providing direction for the design of elements forming the image of the region, namely paths, nodes, landmarks, districts, and edges, based on the historical value of Morotai Island Regency. From the results of this study, recommendations can be given to the Regional Government of Morotai Island Regency to be able to develop and promote marine and historical tourism destinations in Morotai Island Regency as the main tourist attraction, and the natural beauty of Morotai Island Regency is an additional attraction that supports tourism potential in Morotai Island Regency as a whole.
Genome-wide identification of the OMT gene family in Cucumis melo L. and expression analysis under abiotic and biotic stress
Authors: Wang Shuoshuo , Wang Chuang , Lv Futang , Chu Pengfei , Jin Han 
Published: December 2023

Background
O-methyltransferase (OMT)-mediated O-methylation is a frequent modification that occurs during natural product biosynthesis, and it increases the diversity and stability of secondary metabolites. However, detailed genome-wide identification and expression analyses of OMT gene family members have not been performed in melons. In this study, we aimed to perform the genome-wide identification of OMT gene family members in melon to identify and clarify their actions during stress.

Methods
Genome-wide identification of OMT gene family members was performed using data from the melon genome database. The Cucumis melo OMT genes (CmOMTs) were then compared with the genes from two representative monocotyledons and three representative dicotyledons. The basic information, cis-regulatory elements in the promoter, predicted 3-D-structures, and GO enrichment results of the 21 CmOMTs were analyzed.

Results
In our study, 21 CmOMTs (named CmOMT1-21) were obtained by analyzing the melon genome. These genes were located on six chromosomes and divided into three groups composed of nine, six, and six CmOMTs based on phylogenetic analysis. Gene structure and motif descriptions were similar within the same classes. Each CmOMT gene contains at least one cis-acting element associated with hormone transport regulation. Analysis of cis-acting elements illustrated the potential role of CmOMTs in developmental regulation and adaptations to various abiotic and biotic stresses. The RNA-seq and quantitative real-time PCR (qRT-PCR) results indicated that NaCl stress significantly induced CmOMT6/9/14/18 and chilling and high temperature and humidity (HTH) stresses significantly upregulated CmOMT14/18. Furthermore, the expression pattern of CmOMT18 may be associated with Fusarium oxysporum f. sp. melonis race 1.2 (FOM1.2) and powdery mildew resistance. Our study tentatively explored the biological functions of CmOMT genes in various stress regulation pathways and provided a conceptual basis for further detailed studies of the molecular mechanisms.
Comparative diagnostic accuracy of multiparametric magnetic resonance imaging-ultrasound fusion-guided biopsy versus systematic biopsy for clinically significant prostate cancer
Authors: Fang Jian-hua , Zhang Liqing , Xie Xi , Zhao Pan , Bao Lingyun , Kong Fanlei 
Published: December 2023

Purpose
To examine the accuracy of transperineal magnetic resonance imaging (MRI)-ultrasound (US) fusion biopsy (FB) in identifying men with prostate cancer (PCa) that has reached a clinically relevant stage.

Methods
This investigation enrolled 459 males. In 210 of these patients (FB group), transperineal MRI/US fusion-guided biopsies were performed on the suspicious region, and in 249 others, a systematic biopsy (SB) was performed (SB group). We compared these groups using Gleason scores and rates of cancer detection.

Results
PCa cases counted 198/459 (43.1%), including 94/249 (37.8%) in the SB group and 104/210 (49.5%) in the FB group. FB was associated with higher overall diagnostic accuracy relative to SB (88.5% and 72.3%, P = 0.024). FB exhibited greater sensitivity than SB (88.9% and 71.2%, P = 0.025). The area under the curve for FB and SB approaches was 0.837 and 0.737, respectively, such that FB was associated with an 11.9% increase in accuracy as determined based upon these AUC values. Relative to SB, FB was better able to detect high-grade tumors (GS ≥ 7) (78.85% vs. 60.64%, P = 0.025).

Conclusion
Transperineal MRI-US fusion targeted biopsy is superior to the systematic one as an approach to diagnosing clinically significant PCa, as it is a viable technical approach to prostate biopsy.
Chargaff’s second parity rule lies at the origin of additive genetic interactions in quantitative traits to make omnigenic selection possible
Authors: Matkarimov Bakhyt T. , Saparbaev Murat K. 
Published: December 2023

Background
Francis Crick’s central dogma provides a residue-by-residue mechanistic explanation of the flow of genetic information in living systems. However, this principle may not be sufficient for explaining how random mutations cause continuous variation of quantitative highly polygenic complex traits. Chargaff’s second parity rule (CSPR), also referred to as intrastrand DNA symmetry, defined as near-exact equalities G ≈ C and A ≈ T within a single DNA strand, is a statistical property of cellular genomes. The phenomenon of intrastrand DNA symmetry was discovered more than 50 years ago; at present, it remains unclear what its biological role is, what the mechanisms are that force cellular genomes to comply strictly with CSPR, and why genomes of certain noncellular organisms have broken intrastrand DNA symmetry. The present work is aimed at studying a possible link between intrastrand DNA symmetry and the origin of genetic interactions in quantitative traits.

Methods
Computational analysis of single-nucleotide polymorphisms in human and mouse populations and of nucleotide composition biases at different codon positions in bacterial and human proteomes.

Results
The analysis of mutation spectra inferred from single-nucleotide polymorphisms observed in murine and human populations revealed near-exact equalities of numbers of reverse complementary mutations, indicating that random genetic variations obey CSPR. Furthermore, nucleotide compositions of coding sequences proved to be statistically interwoven via CSPR because pyrimidine bias at the 3rd codon position compensates purine bias at the 1st and 2nd positions.

Conclusions
According to Fisher’s infinitesimal model, we propose that accumulation of reverse complementary mutations results in a continuous phenotypic variation due to small additive effects of statistically interwoven genetic variations. Therefore, additive genetic interactions can be inferred as a statistical entanglement of nucleotide compositions of separate genetic loci. CSPR challenges the neutral theory of molecular evolution—because all random mutations participate in variation of a trait—and provides an alternative solution to Haldane’s dilemma by making a gene function diffuse. We propose that CSPR is symmetry of Fisher’s infinitesimal model and that genetic information can be transferred in an implicit contactless manner.
Um estudo sistemático sobre o desenvolvimento Socioeconômico e cultural urbano de Benjamin Constant: uso da água, o caso do igarapé “sai de cima Miguel localizado na fronteira entre Brasil e Peru”
Authors: Da Costa Ciderjânio Farling Salvador , Sales Bismark Junior Martins , Silva Francisco Gladson 
Published: December 2023

O ser humano, ao longo de sua ocupação espacial histórica e de seu processo de desenvolvimento e sobrevivência, manteve, e ainda mantém relações diretas e significativas com a natureza, assim, abordar a relação sociedade versos natureza, constitui estudar as interações das atividades igualitárias, econômicas e políticas e de saúde que de certa forma está diretamente vinculada ao ambiente e suas respectivas implicações quanto à sustentabilidade humana. Nesse contexto, a presente pesquisa teve como procedimento inicial o levantamento às questões socioeconômicas, cultural urbano e de saúde no município Benjamin Constant-AM. Nesse contexto, a presente pesquisa teve como procedimento inicial o levantamento às questões socioeconômicas, cultural urbano e de saúde no município Benjamin Constant-AM, especificamente, quanto ao uso da água, enfocando o caso do Igarapé “Sai de Cima Miguel” localizado no bairro Umarizal e Javarizinho. Independente da interferência da sociedade é importante considerar a dinâmica natural impulsionada pelas ações impactantes na qual são caracterizadas como o grande paradigma a ser quebrado frente às grandes degradações que esse igarapé vem sofrendo ao longo dos anos. Nessa perspectiva, o trabalho busca a compreensão das circunstâncias que levam os moradores às práticas de ações impactantes no citado igarapé, comprometendo com a destituição da qualidade da água, bem como, sua sustentabilidade, já que é importante fonte hídrica e natural. Sabe-se que o homem vem produzido ações impactantes negativas desde que ele pautou-se pelo paradigma de uso indiscriminado dos recursos naturais, desconsiderando sua finitude e relações equilibradas e sustentadas ambientalmente.
Evaluating the Predictive Performance of Monthly Inflation Rates in Sri Lanka using the Hybrid Model (HB)
Authors: Bandara W. M. S. , Mel W. A. R. De 
Published: December 2023

Aims/ objectives: This study develops and evaluates a novel hybrid model (HB) for forecasting monthly inflation rates in Sri Lanka, a country with a unique economic context, from 1988 to 2021. By integrating the Autoregressive Integrated Moving Average (ARIMA) and Artificial Neural Networks (ANNs), the study aims to overcome the limitations of traditional linear models in capturing the nonlinear patterns often observed in Sri Lankan economic data.
Objectives: The study aims to assess the predictive accuracy of the HB model against established models, emphasizing its adaptability and robustness over a historically significant period.
Methodology: Utilizing historical data, the study compares the HB model's forecasting performance with other established models, focusing on the Mean Absolute Percentage Error (MAPE) as a key metric of predictive accuracy.
Results: The HB model demonstrates superior forecasting accuracy, with a notable reduction in MAPE to 7.10%, indicating its effectiveness in capturing the complexities of the Sri Lankan inflation trend.
Conclusion: This study contributes to the field of economic forecasting by presenting a model that not only provides more accurate predictions but also adapts to the specific economic conditions of Sri Lanka. The findings have significant implications for economic planning and policy-making, highlighting the utility of hybrid forecasting models in developing economies.
Phenotypic and Genetic Characterization of Polyhydroxyalkanoate Producing Bacterial Isolates from Hypersaline Water Body, Atlantic Ocean, Nigeria
Authors: Fayemi Scott O.  , Akiibinu Moses O.  , Fatokun Evelyn N.  , Orukotan Abimbola A.  
Published: December 2023

Introduction: The importance of polyhydroxylalkanoate (PHA) producing bacteria is hinged on the basis that PHA itself possess environmentally advantages over synthetic plastics therefore, the proper identity of these bacteria is inevitable.
Aim: To determine the bacteria identification methods of phenotypic and genetic identification for marine sourced effective polyhydroxylalkanoate (PHA) production.
Study Design: Randomised design was employed for PHA producing bacterial isolates.
Place and Duration of Study: Samples containing PHA-producing bacteria from the hypersaline water body of Nigerian Southern Atlantic Ocean (6.35ᴼ N 3.28ᴼ E -St1; 6.35ᴼ N 3.40ᴼ E -St2; and 6.36ᴼ N 3.47ᴼ E -St3); water depths (0.07m (top), 50m (middle) and 100m (bottom) were collected and investigated between August, 2016-September, 2019.
Methodology: Bacterial isolates was characterized using standard microbiological and biochemical tests for the phenotypes, and 16S rDNA for the genotypes. Isolates were also screened for PHA potentials using specific primers.
Results: Genetically identified Bacillus cereus strains LB17 and Bacillus paramycoides SA27 were phenotypically identified as Bacillus badius. Similarly, Acinetobacter calcoaceticus JL11, five strains of Alcaligenes faecalis, seven strains of Bacillus spp., Enterobacter cloacae, Falsochrobactrum ovis, Ochrobactrum ciceri, Providencia stuartii including two species of Pseudomonas and Bordetella trematum were all phenotypically identified as Corynebacterium kutsceri. Invariably, Alcaligenes faecalis (strains PSD10 and DEP8), Pseudomonas aeruginosa (H47921) and Vagococcus fluvialis (AWW1) were identified as Staphylococcus species. All 34 bacterial isolates expressed phaC genes for PHA potential, while Alcaligenes faecalis strains and Bacillus humi (NBPP9) expressed phaC1 for short PHA chain.
Conclusion: This study established variations in the genetical identity of Corynebacterium kutsceri, Enterobacter amnigenus, Micrococcus luteus, Micrococcus varians, Staphylococcus epidermidis and Staphylococcus saprophyticus when compared with the phenotypic identification methods. But, there was synchronization in the genotypic and phenotypic identity of bacillus species. Records of varietal differences of PHA potential were also obtained from same species in this research. It is therefore pertinent to rely on the genetic identification of bacteria for the effective determination of PHA-producing character as displayed in Bacillus spp.
Engineered Materials: Bioinspired “Good Enough” versus Maximized Performance
Authors: van Nieuwenhoven Richard W. , Drack Manfred , Gebeshuber Ille C. 
Published: December 2023

AbstractUtilizing various materials is fundamental for the production of physical objects. However, processing raw materials during production often leads to complex transformations that hinder the recyclability of modern high‐performance materials. These materials possess increased durability and resilience, challenging their decomposition and limiting their potential for recycling and reuse. In contrast, living Nature manages material utilization without such complications. The emerging discipline of Engineered Living Materials (ELMs) shifts the focus to self‐repairing, self‐supporting growing materials, emphasizing overall sustainability. To effectively address the challenges associated with high‐performance materials, the design process must incorporate considerations of recycling and decomposition from the outset. Environmental challenges associated with material utilization can be addressed by reevaluating material design and prioritizing recycling, decomposition, and embracing Nature's “good enough” principle. The transition toward sustainable resource management requires substantial investment in scientific research that explores the mechanisms by which life sustains itself using solely local resources. Biomimetics and ELMs offer valuable insights, but a deeper understanding of how Nature efficiently utilizes resources is crucial. The integration of engineering advantages not identified in Nature, such as product sub‐unit reuse, can complement these efforts. Paving the way toward a sustainable future requires a comprehensive approach rooted in biological evolution and innovative scientific research.