bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sufficiency of a Single Negative Thyroglobulin Standard for Judging the
Success of Ablation in Low- and Intermediate-risk Differentiated Thyroid
Cancer: A Retrospective Study
Authors: Long Yahong , Jin Jianhua , Zhang Wanchun 
Published: January 2024

Background:
We investigated how reduced successful ablation criteria may be used
to evaluate radioiodine remnant ablation in patients with low- and intermediate-differentiated
thyroid carcinoma (DTC).

Methods:
Overall, 254 low- and intermediate-risk patients with DTC were categorized into
three groups (positive, weak, positive, and negative) on the basis of a visual study of thyroid
imaging performed before postoperative iodine treatment. Semi-quantitative analysis parameters
were incorporated into the positive Tc-99m pertechnetate scanning to further examine the clinical
use of thyroid imaging. We investigated the value of successful judgment criteria and the
influencing factors of radioiodine ablation. At the same time, the predictive value of thyroglobulin
(Tg) for radioiodine treatment and the overall clinical efficacy were assessed.

Results:
A total of 250 (98.43%) patients were identified as having functional thyroid tissue
residue on the Rx-whole-body scan, and 137 (53.94%) patients had positive Tc-99m pertechnetate
scans using semi-quantitative analysis. The single Tg standard could not substitute the double
standard (χ2c=22.042, p< 0.001) for patients with residual thyroid weight by a semiquantitative
analysis. However, the semi-quantitative analysis revealed no association between
99mTcO4−thyroid scan and ablation treatment using semi-quantitative analysis; only preablation
sTg levels were related with success in the multivariate logistic regression analysis,
with a cut-off value of 2.88 ng/mL. The pre-ablation stimulated Tg level was also the primary
factor of satisfactory response following follow-up with an optimal cut-off of 6.506 ng/mL.

Conclusion:
Even in low- and intermediate-risk patients with DTC, a single negative Tg standard
also requires receiving some restrictions in the evaluation of ablation success and is inadequate.
Conventional 99mTcO4 thyroid imaging combined with a quantitative analysis program
can improve the clinical practice of single negative Tg standard.
Designing a Secretory form of RTX-A as an Anticancer Toxin: An
In Silico Approach
Authors: Taheri-Anganeh Mortaza , Nezafat Navid , Gharibi Saba , Khatami Seyyed Hossein , Vahedi Farzaneh , Shabaninejad Zahra , Asadi Marzieh , Savardashtaki Amir , Movahedpour Ahmad , Ghasemi Hassan 
Published: January 2024

Background:
Cancer is a leading cause of death and a significant public health
issue worldwide. Standard treatment methods such as chemotherapy, radiotherapy, and
surgery are only sometimes effective. Therefore, new therapeutic approaches are needed
for cancer treatment. Sea anemone actinoporins are pore-forming toxins (PFTs) with
membranolytic activities. RTX-A is a type of PFT that interacts with membrane phospholipids,
resulting in pore formation. The synthesis of recombinant proteins in a secretory
form has several advantages, including protein solubility and easy purification. In this
study, we aimed to discover suitable signal peptides for producing RTX-A in Bacillus
subtilis in a secretory form.

Methods:
Signal peptides were selected from the Signal Peptide Web Server. The probability
and secretion pathways of the selected signal peptides were evaluated using the
SignalP server. ProtParam and Protein-sol were used to predict the physico-chemical
properties and solubility. AlgPred was used to predict the allergenicity of RTX-A linked
to suitable signal peptides. Non-allergenic, stable, and soluble signal peptides fused to
proteins were chosen, and their secondary and tertiary structures were predicted using
GOR IV and I-TASSER, respectively. The PROCHECK server performed the validation
of 3D structures.

Results:
According to bioinformatics analysis, the fusion forms of OSMY_ECOLI and
MALE_ECOLI linked to RTX-A were identified as suitable signal peptides. The final
proteins with signal peptides were stable, soluble, and non-allergenic for the human body.
Moreover, they had appropriate secondary and tertiary structures.

Conclusion:
The signal above peptides appears ideal for rationalizing secretory and soluble
RTX-A. Therefore, the signal peptides found in this study should be further investigated
through experimental researches and patents.
Revolutionizing Nitrofurantoin Delivery: Unraveling Challenges and
Pioneering Solutions for Enhanced Efficacy in UTI Treatment
Authors: Nanda Gouri P. , Patel Mrunali , Patel Rashmin B. 
Published: January 2024

Abstract:
Nitrofurantoin is an antimicrobial drug, highly effective in the treatment of critical or chronic bacterial infections of the urinary tract, and hence, it is the first line choice of drug for the treatment of urinary tract infections (UTI). Although the molecule is legacy in nature, there are many challenges in terms of drug product formulation and efficacy thereof. The authors are main-ly focused in this literature review on, but not limited to, understanding the molecule in terms of physico-chemical properties of the drug, pharmacokinetics and pharmacodynamics, approved and withdrawn formulations, challenges concerning drug formulation, the cause of drug shortage in the market, improvement areas in terms of formulation and its therapeutic effectiveness. The au-thors found during their widespread review that the major challenge in the existing conventional drug delivery system of nitrofurantoin is the fluctuation of plasma concentration owing to its var-iability in drug absorption. Further, they understood that the variability in absorption is due to in-herent variability in particle size distribution. Based on the findings, authors also explored the possibilities to deliver the drug in novel drug delivery systems such as nano self-emulsifying emulsions, nanoemulsions and multiple emulsions where the drug can be presented in soluble form and hence the variability in absorption and fluctuation in plasma concentration of drug can be avoided and described briefly the salient features of each drug delivery in this review.
Assessment of renal and cardiovascular risks in patients with type 2 diabetes when using non-steroidal mineralocorticoid receptor antagonists
Authors: Yerokhovych V.М. , Komisarenko Y.I. , Karpenko O.V. , Pankiv V.I. , Kobyliak N.M. , Bobryk M.I. , Kyriienko D.V. , Gurska K.S. , Kaplina A.A. , Vasiuk V.L. 
Published: January 2024

Background. Given the proven excessive activation of the renin-angiotensin-aldosterone system and the clinical manifestations of hypertension, mostly of renal origin, there is a need to optimize antihypertensive therapy aimed at an active nephroprotection. The purpose of the study is to carry out a comprehensive assessment of kidney and heart risk factors in patients with type 2 diabetes mellitus and chronic kidney disease (CKD) and to justify the administration of non-steroidal mineralocorticoid receptor antagonists to these patients. Materials and methods. In a prospective cohort study, 88 patients with type 2 diabetes were examined: group 1 — estimated glomerular filtration rate (eGFR) < 60 ml/min/m2, group 2 — eGFR ≥ 60 ml/min/m2. eGFR was evaluated according to the CKD-EPI (Chronic Kidney Disease Epidemiology Colla­boration) formula based on serum creatinine. GFR category was defined according to the KDIGO (Kidney Disease: Improving Global Outcomes) criteria. The albumin-creatinine ratio was calcula­ted. The level of glycated hemoglobin (HbA1c) was assessed by the method of high-performance liquid chromatography. Aldosterone was evaluated by immunoenzymatic method. Results. In patients with eGFR < 60 ml/min/m2, the albumin-creatinine ratio in daily urine is statistically significantly higher compared to group 2. Patients with eGFR < 60 ml/min/m2 had an average uric acid level of 410.3 ± 98.8 μmol/l, which is statistically significantly higher than in those with eGFR ≥ 60 ml/min/m2 — 321.10 ± 74.54 μmol/l. A statistically significant correlation between the level of uric acid and markers of renal dysfunction was found only in patients with eGFR < 60 ml/min/m2. Aldosterone levels were higher in the first group. No statistical difference was found between the average value of HbA1c in the studied groups. Conclusions. Numerous factors of unfavorable prognosis regarding kidney and heart risks have been identified: hypertension, increased albumin-creatinine ratio and cholesterol, unsatisfactory compensation of diabetes, obesity. There is an increase in the frequency of resistant hypertension, hyperuricemia, and hyperaldosteronism in patients with decreased eGFR. In patients with diabetic kidney damage on the background of type 2 diabetes, the administration of finerenone, a non-steroidal mine­ralocorticoid receptor antagonist, at a dose of 10–20 mg/day is pathogenetically justified.
INTRODUKSI DAN PELATIHAN SISTEM INFORMASI AKADEMIK DI SMAN 1 MAJALAYA
Authors: Finandhita Alif , Maulana Hanhan , Dwi Agustia Richi , Suryana Taryana , Atin Sufa , Afrianto Irawan 
Published: January 2024

Dalam era digitalisasi dan teknologi informasi yang terus berkembang, integrasi teknologi dalam proses pembelajaran dan administrasi akademik menjadi sebuah keharusan untuk meningkatkan efisiensi dan efektivitas penyelenggaraan pendidikan. SMAN 1 Majalaya membutuhan suatu sistem informasi akademik (SIA) yang dapat membantu dalam mengelola data siswa, jadwal pelajaran, catatan kehadiran, dan informasi akademik lainnya. Pengembangan SIA menjadi solusi guna mengatasi permasalahan tersebut. Pendekatan yang digunakan dalam kegiatan pengabdian ini mencakup identifikasi masalah dan desain solusi, pengembangan SIA, pengenalan dan pelatihan SIA, serta evaluasi hasil kegiatan pengabdian. Hasil yang diperoleh menunjukkan bahwa SIA telah dapat diimplementasi di lingkungan SMAN 1 Majalaya, introduksi serta pelatihan SIA juga menghasilkan temuan peningkatan kemampuan guru dan tenaga kependidikan dalam pengolahan data akademik dengan lebih cepat, mudah dan efisien.
Pengaruh Tekanan Karyawan, Tekanan Pemegang Saham dan Gender Diversity terhadap Kualitas Sustainability Report
Authors: Putri Nabilah Aisha , NR Erinos 
Published: January 2024

The purpose of this research is to examine the impact of employee pressure, shareholder pressure and gender diversity on the quality of sustainability report. To assess the quality of sustainability reports, this study employs the SRQ value, which is a disclosure index based on the GRI-Standard. The population of this research are companies listed on the Indonesia Stock Exchange (IDX) over a five-year period from 2017 – 2021. By using the purposive sampling method, this research obtained 48 samples that met the criteria. This research uses multiple linear regression analysis in hypotheses testing. The findings indicate that employee pressure and shareholder pressure has a negative and significant effect on the quality of sustainability reports. On the other hand, gender diversity do not have any effect on the quality of sustainability reports.Thus, all the hypotheses proposed in this study were rejected.
Pengaruh Profitabilitas, Thin Capitalization dan Transfer Pricing terhadap Agresivitas Pajak
Authors: Lestari Nanda , Syofyan Efrizal 
Published: January 2024

This study was conducted to investigates the influence of profitability, thin capitalization and transfer pricing on tax aggressiveness in non-financial multinational companies listing on (BEI) the Indonesia Stock Exchange in 2019-2021. Population was determined using purposive sampling, 36 companies were selected. Data was processed using SPSS 26 with multiple linear regression analysis method. The findings prove that profitability and transfer pricing have no influence on tax aggressiveness, while thin capitalization has a significant influence on tax aggressiveness.
The Pengungkapan Informasi Tentang Digitalisasi dan Nilai Perusahaan
Authors: Firmansyah Rian , Helmy Herlina 
Published: January 2024

The purpose of this study is to find out how the effect of disclosing information about digitalization on company value in the food & beverage sub-sector, the textile & garment sub-sector, and the chemical sub-sector which are listed on the Indonesian stock exchange. This research is included in the type of causality research using a quantitative approach. The data in this study were sourced from company annual reports obtained from the website of the Indonesian stock exchange and the website of each company that was sampled. In testing the hypothesis, this study used panel data regression analysis using Eviews software version 12. Based on tests carried out, the results of this research show that disclosing information about digitalization has no effect on the value of companies in the food & beverage subsector, textile & garment subsector, and chemicals subsector listed on the Indonesian Stock Exchange for the 2019 - 2021 period.
Pengaruh Locus of Control, Kinerja Auditor dan Etika Profesi terhadap Perilaku Disfungsional Auditor: Studi Empiris pada KAP di Kota Padang
Authors: Wulandari Dwika Fitria , NR Erinos 
Published: January 2024

This study aims to examine the influence of external locus of control, internal locus of control, auditor performance and professional ethics on auditor dysfunctional behavior. The population in this study were all public accounting firms in the city of Padang, using the total sampling method. There were 7 public accounting firms that could be used us research samples and 44 questionnaires were collected. The data analysis method used in this research is multiple linear regression. The result of this study show that external locus of control has a positive effect on auditor dysfunctional behavior, while internal locus of control, auditor performance and professional ethics have a negative effect on auditor dysfunctional behavior.
Pengaruh Audit Tenure, Komite Audit, dan Audit Delay terhadap Auditor Switching
Authors: Bakar Rahayu Surya , Syofyan Efrizal 
Published: January 2024

This research aimed to examine the effect of audit tenure, audit committee, and audit delay on auditor switching. The population in this research are all infrastructure, utilities, and transportation companies listed on the Indonesia Stock Exchange in 2016-2021. The sampling technique used the purposive sampling. Total sample are 108 companies. The statistical method used logistic regression analysis. The result showed that audit tenure, audit committee and audit delay had no influence on auditor switching in infrastructure, utilities, and transportation companies listed on the Indonesia Stock Exchange in 2016-2021.
An ethical analysis of media’s usage of Artificial Intelligence. A case-study on Associated Press
Authors: ȘTEFĂNEL Ana-Iuliana 
Published: January 2024

This article provides a theoretical examination of the utilization of artificial intelligence (AI) by the Associated Press (AP), focusing on the ethical considerations inherent in its AI practices. With a historical legacy spanning 170 years, AP has evolved into a global news agency that embraces AI across various facets of its operations. The study explores AP's integration of AI in areas such as content generation, data journalism, language translation, and audience engagement, emphasizing the ethical dimensions of these applications.
The ethical framework employed by AP is scrutinized through an analysis of its coverage depth, content quality, and transparency. The study also delves into the ethical implications of AP's automatic content generation processes, which leverage AI algorithms for expeditious news production. Emphasizing the symbiotic relationship between AI and journalism, the research contemplates how technology can augment human capacities while necessitating vigilance against potential biases and misinformation.
Furthermore, the study scrutinizes how AP navigates ethical challenges in language translation, audience engagement, and market analysis through AI. The agency's use of AI to enhance multimedia elements, personalize content, and forecast audience interests prompts an exploration of the ethical implications of tailoring information to individual preferences. By examining the agency's multifaceted use of AI, the study contributes valuable insights into the evolving relationship between journalism, technology, and ethical responsibility. Ultimately, it underscores the imperative for news organizations to adopt principled approaches to AI integration, ensuring that advancements in technology align with ethical journalism practices.
Mística, filosofía y mujeres
Authors: Fernández Martín Patricia 
Published: January 2024

Este trabajo propone una vuelta a la relación entre ética y religión (cristiana) a partir de la recuperación hermenéutica de textos femeninos. Para ello, se comienza explicando por qué se considera relevante la religión para determinar un tipo de ética, siguiendo a tres grandes filósofos como son Bergson, Kant y Kolakowski. Después, se les da voz a algunas de las mujeres religiosas que han testificado vivir en sus carnes la experiencia de lo Absoluto y, a la vez, han sufrido una doble invisibilización (por ser religiosas y por ser mujeres). Dado que no se les ha permitido construir discursos plenamente filosófico-teológicos, han necesitado apoyarse en sus experiencias religiosas para configurar las pautas que marquen su comportamiento. De todo ello se puede extraer cierta aplicación práctica del doble núcleo de la ética del amor cristiano: amar a Dios sobre todas las cosas y al prójimo como a uno mismo.
POLA STRUKTUR DAN SEMANTIS KOLOKASI VERBA DAN PREPOSISI DALAM SURAH AL-BAQARAH
Authors: YANTI SOFIA WILDA , NUGRAHA TUBAGUS CHAERU , FACHRULLAH TUBAGUS ACE 
Published: January 2024

Bahasa Arab di dalam Al-Qur’an sangat unik dan kaya dengan aspek gabungan kata, namun belum banyak para peneliti yang mengkaji gabungan kata dalam bahasa Arab, terutama masalah kolokasi. Tujuan penulis meneliti ini yaitu agar mengetahui struktur dan pola kolokasi yang terdapat dalam surah al-Baqarah. Metode penelitian yang digunakan dalam penelitian ini adalah metode kualitatif dengan kajian data induktif dan analisis deskriptif, dengan metode analisis data distribusional dan metode padan translasional. Berdasarkan hubungan gramatikalnya, kedudukan preposisi tersebut ada yang bersifat ta’diyah (penghubung verba dengan objek), umumnya kolokasi seperti ini bersifat obligatori (wajib), dan adapula preposisi yang berjabatan sebagai al-mukammila>t yaitu fungsi keterangan dalam kalimat, umumnya pola kolokasi tersebut bersifat opsional. Berdasarkan pengaruh makna yang dihasilkannya, penulis mengklasifikasikan kolokasi verba dan preposisi ke dalam tiga hubungan makna, yaitu ta’aqub, musytarak al-lafdzi, dan al-huqu>l al-dilaliyah.
IMPLEMENTASI SETSUZOKUSHI DALAM CERITA ANAK KOMEBUKU TO NUKABUKU: KAJIAN STRUKTUR DAN MAKNA
Authors: ARDIATI RIZA LUPI , SUGIARTO SIGIT 
Published: January 2024

Penelitian ini bertujuan mengimplementasikan setsuzokushi atau konjungsi bahasa Jepang yang terdapat dalam cerita anak Komebuku to Nukabuku. Pendekatan struktur dan makna yang digunakan untuk mencari bentuk dan fungsi serta jenis setsuzokushi, serta maknanya. Metode studi pustaka analisis deskriptif, teknik sadap rekam dan catat digunakan untuk mengklasifikasi dan menganalisis data setsuzokushi. Hasil penelitian menyimpulkan bahwa dari data cerita anak Komebuku to Nukabuku mendapatkan hanya 3 jenis setsuzokushi, yaitu konjungtor junsetsu yang diwakili suruto, konjungtor gyakusetsu : tokoro ga, demo, keredo dan kedo dan konjungtor tenkai, yang diwakili sonnara .
KESALAHAN PENGGUNAAN ADVERBIA再 ZÀI DAN又 YÒU PADA MAHASISWA PROGRAM STUDI BAHASA DAN BUDAYA TIONGKOK FAKULTAS ILMU BUDAYA UNIVERSITAS PADJADJARAN
Authors: CLEVERESTY TRI BIGRIT , AFRINA URAY 
Published: January 2024

This research aimed to determine the misuse of the adverbs再 zài and 又yòu on the Chinese Language and Culture at Faculty of Cultural Science Universitas Padjadjaran. Chinese language learners. This research applied qualitative approach with data collection techniques using the test techniques through test instruments. Result shows that the error rate of using the adverbs再 zài and 又yòu reached 30%,with four types of errors; omission ,addition, misselection and misordering. The factors that influenced these misuse are: the interlingual factor or the factor from the mother tongue, the intralingual factor from the students' understanding levels and students' vocabulary mastery, and the last factor is the performance error factor.
Pemanfaatan Microsoft Access Untuk Peningkatan Kualitas Data Kesehatan Pada Desa Penfui Timur
Authors: Wawo Maria Monte K. , Nggau Gaudensius Avilia , Dida Allen Malkiel J. , Silab Gregorius Rian , Wijaya Adi Bagus Putra , Samungor Priskyanus Kewanajan , Meco Luzia Corbafo , Neonnub Yohanes , Noni Stelin , Bria Yulianti Paula , Ngaga Emerensiana 
Published: January 2024

Kemajuan teknologi kesehatan yang cepat dan akurat semakin menjadi kebutuhan utama para pengambil keputusan. Dalam skala kecil seperti klinik, puskesmas sebagai institusi kesehatan yang menyimpan banyak data juga membutuhkan pengelolahan data yang benar dan tepat sehingga dapat disajikan dalam bentuk laporan. Sedang untuk menyimpan arsip data kesehatan memerlukan tempat aman yang rawan terkena dampak bencana alam dan kebakaran. Desa Penfui Timur adalah salah satu desa yang memerlukan perbaikan dalam perekaman data kesehatan agar dapat memberikan pelayanan yang lebih baik kepada masyarakat. Microsoft Access merupakan salah satu program aplikasi pengelola database yang bisa digunakan untuk merancang, membuat, dan mengelola berbagai jenis data. Metode Penggunaan Microsoft Accses yang dapat diterapkan di Desa Penfui Timur dapat membantu pencatatan data kesehatan sehingga meningkatkan kualitas data kesehatan untuk mendukung pengambilan keputusan yang lebih baik di bidang kesehatan dan pelayanan masyarakat.