bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simira cordifolia protects against metal induced-toxicity in Caenorhabditis elegans
Authors: Duran-Izquierdo Margareth , Sierra-Marquez Lucellys , Taboada-Alquerque Maria , Olivero-Verbel Jesus 
Published: November 2023

Simira cordifolia (Hook.f.) Steyerm (Rubiaceae) is a vascular plant used in Northern Colombia as a source of pigments and wood. However, there is a lack of information regarding its pharmacology and toxicity. This research aimed to study the hydroalcoholic extract of Simira cordifolia as a protector against metal-induced toxicity in Caenorhabditis elegans. Preliminary phytochemical screening of the hydroalcoholic extract of S. cordifolia (HAE-Sc) was conducted using HPLC-ESI-QTOF. Wild-type N2 C. elegans larvae were exposed to different concentrations of HAE-Sc evaluating lethality (50–5000 μg/mL), growth, lifespan, resistance to heat stress, and its protective effect against Mercury (Hg)-, Lead (Pb)- and Cadmium (Cd)-induced lethality (50–1000 μg/mL). The main metabolites present in the extract were iridoids, β-carboline-alkaloids and polyphenols. Bioassays demonstrated that HAE-Sc exhibited low toxicity, with significant lethality (4.2% and 9.4%) occurring at 2500–5000 μg/mL. Growth inhibition reached up to 23.3%, while reproduction declined 13% and 17% at concentrations 500 and 1000 μg/mL, respectively. HAE-Sc enhanced the survival rate of the nematode under thermal stress by up to 79.8%, and extended the mean lifespan of worms by over 33% compared to control. The average lifespan was prolonged by 15.3% and 18.5% at 50 and 100 μg/mL HAE-Sc, respectively. The extract (1000 μg/mL) was able to reduce the death of C. elegans in the presence of heavy metals up to 65.9, 96.8% and 87% for Pb, Hg, and Cd, respectively. In summary, S. cordifolia shows potential protective effects in C. elegans against toxicity caused by heavy metals and heat.
Efficacy and safety of sedation with dexmedetomidine in adults undergoing gastrointestinal endoscopic procedures: systematic review and meta-analysis of randomized controlled trials
Authors: Tang Rou , Huang Yaqun , Zhang Yujia , Ma Xiaolei , Yu Haoyang , Song Kaichao , Ren Ling , Zhao Bin , Wang Lulu , Zheng Wensheng 
Published: November 2023

Background: The sedative role of dexmedetomidine (DEX) in gastrointestinal endoscopic procedures is unclear. We performed this systematic review and meta-analysis to assess the efficacy and safety of sedation with DEX during gastrointestinal endoscopic procedures with a view to providing evidence-based references for clinical decision-making.Methods: The PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases were searched for randomized controlled trials (RCTs) that compared DEX with different sedatives comparators (such as propofol, midazolam, and ketamine) for sedation in a variety of adult gastrointestinal endoscopic procedures from inception to 1 July 2022. Standardized mean difference (SMD) and weighted mean difference (WMD) with 95% confidence interval (CI) or pooled risk ratios (RR) with 95% CI were used for continuous outcomes or dichotomous outcomes, respectively, and a random-effect model was selected regardless of the significance of the heterogeneity.Results: Forty studies with 2,955 patients were assessed, of which 1,333 patients were in the DEX group and 1,622 patients were in the control (without DEX) group. The results suggested that the primary outcomes of sedation level of DEX are comparable to other sedatives, with similar RSS score and patient satisfaction level, and better in some clinical outcomes, with a reduced risk of body movements or gagging (RR: 0.60; 95% CI: 0.37 to 0.97; p = 0.04; I2 = 68%), and a reduced additional requirement for other sedatives, and increased endoscopist satisfaction level (SMD: 0.41; 95% CI: 0.05 to 0.77; p = 0.03; I2 = 86%). In terms of secondary outcomes of adverse events, DEX may benefit patients in some clinical outcomes, with a reduced risk of hypoxia (RR:0.34; 95% CI: 0.20 to 0.55; p &lt; 0.0001; I2 = 52%) and cough (RR: 0.25; 95% CI: 0.12 to 0.54; p = 0.0004; I2 = 0%), no significant difference in the risk of hypotension, while an increased risk of bradycardia (RR: 3.08; 95% CI: 2.12 to 4.48; p &lt; 0.00001; I2 = 6%).Conclusion: This meta-analysis indicates that DEX is a safe and effective sedative agent for gastrointestinal endoscopy because of its benefits for patients in some clinical outcomes. Remarkably, DEX is comparable to midazolam and propofol in terms of sedation level. In conclusion, DEX provides an additional option in sedation for gastrointestinal endoscopic procedures.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/#searchadvanced
A retrospective case-control study to evaluate the use of beta-lactam desensitization in the management of penicillin-allergic patients: a potential strategy for Antimicrobial Stewardship Programs
Authors: Rodríguez-Alarcón Alicia , Sanz de Mena Manuela , Alanti Soukaina Sara , Echeverría-Esnal Daniel , Sorli Luisa , Sendra Elena , Benítez-Cano Adela , Membrilla Estela , Cots Francesc , Güerri-Fernández Robert , Adalia Ramón , Horcajada Juan Pablo , Escolano Fernando , Grau Santiago , Gómez-Zorrilla Silvia 
Published: November 2023

Introduction: Penicillin allergy labels (PAL) are common in the hospital setting and are associated with worse clinical outcomes. Desensitization can be a useful strategy for allergic patients when alternative options are suboptimal or not available. The aim was to compare clinical outcomes of patients with PAL managed with antibiotic desensitization vs. those who received alternative non-beta-lactam antibiotic treatments.Methods: A retrospective 3:1 case-control study was performed between 2015–2022. Cases were adult PAL patients with infection who required antibiotic desensitization; controls were PAL patients with infection managed with an alternative antibiotic treatment. Cases and controls were adjusted for age, sex, infection source, and critical or non-critical medical services.Results: Fifty-six patients were included: 14 in the desensitization group, 42 in the control group. Compared to the control group, desensitized PAL patients had more comorbidities, with a higher Charlson index (7.4 vs. 5; p = 0.00) and more infections caused by multidrug-resistant (MDR) pathogens (57.1% vs. 28.6%; p = 0.05). Thirty-day mortality was 14.3% in the desensitized group, 28.6% in the control group (p = 0.24). Clinical cure occurred in 71.4% cases and 54.8% controls (p = 0.22). Four control patients selected for MDR strains after alternative treatment; selection of MDR strains did not occur in desensitized patients. Five controls had antibiotic-related adverse events, including Clostridioides difficile or nephrotoxicity. No antibiotic-related adverse events were found in the study group. In multivariate analysis, no differences between groups were observed for main variables.Conclusion: Desensitization was not associated with worse clinical outcomes, despite more severe patients in this group. Our study suggests that antibiotic desensitization may be a useful Antimicrobial Stewardship tool for the management of selected PAL patients.
Research on sweat metabolomics of athlete’s fatigue induced by high intensity interval training
Authors: Meihua Su , Jiahui Jin , Yujia Li , Shuang Zhao , Jingjing Zhan 
Published: November 2023

Objective: Sweat is an important specimen of human metabolism, which can simply and non-invasively monitor the metabolic state of the body, and its metabolites can be used as biomarkers for disease diagnosis, while the changes of sweat metabolites before and after exercise-induced fatigue are still unclear.Methods: In this experiment, high-performance chemical isotope labeling liquid chromatography-mass spectrometry (LC-MS) was used to metabolomic 28 sweat samples before and after exercise-induced fatigue of 14 long-distance runners, also IsoMS PRO and SPSS22.0 software were used to analyze the metabolite changes and differential metabolic pathways.Results: A total of 446 metabolites with high confidence were identified, and the sweat metabolome group before and after high-intensity interval exercise-induced fatigue was obvious, among which the upregulated differential metabolites mainly included hypoxanthine, pyruvate, several amino acids, etc., while the downregulated differential metabolites mainly included amino acid derivatives, vitamin B6, theophylline, etc.Conclusion: The change of hypoxanthine concentration in sweat can be used as a good biomarker for the diagnosis of exercise-induced fatigue, while the change of pyruvate content in sweat can be used as a discriminant index for the energy metabolism mode of the body before and after exercise. The main metabolic pathways involved in differential metabolites produced before and after HIIT exercise-induced fatigue are purine metabolism and amino acid metabolism.
The relationships among nature connectedness, climate anxiety, climate action, climate knowledge, and mental health
Authors: Thomson Emily E. , Roach Sean P. 
Published: November 2023

IntroductionClimate change is a source of global concern that has both direct and general impacts on mental health. A recent study conducted following severe bushfires in Australia demonstrated relationships among nature connectedness, climate action, climate worry, and mental health; for example, nature connectedness was associated with climate worry, which in turn was associated with psychological distress.MethodsThe present study sought to replicate those findings while building on them in two important ways: on those findings in two ways: first, test similar relationships in a different geographical context that has been mostly spared from direct impacts by acute climate events; second, we take into consideration an additional factor, climate knowledge, which has been linked to relevant factors such as climate anxiety.ResultsThe results of a survey completed by 327 adults revealed a similar relationship between nature connectedness and climate anxiety, and between that and psychological distress. Further mirroring those previous findings, nature connectedness was associated with both individual and collective climate action, but the relationships between them and psychological distress differed.DiscussionThe proposed model was a better fit to the collected data among those with high levels of climate change knowledge than those with low levels, suggesting that such knowledge influences how the above factors relate to each other.
A search-based geographic metadata curation pipeline to refine sequencing institution information and support public health
Authors: Zhao Kun , Farrell Katie , Mashiku Melchizedek , Abay Dawit , Tang Kevin , Oberste M. Steven , Burns Cara C. 
Published: November 2023

BackgroundThe National Center for Biotechnology Information (NCBI) Sequence Read Archive (SRA) has amassed a vast reservoir of genetic data since its inception in 2007. These public data hold immense potential for supporting pathogen surveillance and control. However, the lack of standardized metadata and inconsistent submission practices in SRA may impede the data’s utility in public health.MethodsTo address this issue, we introduce the Search-based Geographic Metadata Curation (SGMC) pipeline. SGMC utilized Python and web scraping to extract geographic data of sequencing institutions from NCBI SRA in the Cloud and its website. It then harnessed ChatGPT to refine the sequencing institution and location assignments. To illustrate the pipeline’s utility, we examined the geographic distribution of the sequencing institutions and their countries relevant to polio eradication and categorized them.ResultsSGMC successfully identified 7,649 sequencing institutions and their global locations from a random selection of 2,321,044 SRA accessions. These institutions were distributed across 97 countries, with strong representation in the United States, the United Kingdom and China. However, there was a lack of data from African, Central Asian, and Central American countries, indicating potential disparities in sequencing capabilities. Comparison with manually curated data for U.S. institutions reveals SGMC’s accuracy rates of 94.8% for institutions, 93.1% for countries, and 74.5% for geographic coordinates.ConclusionSGMC may represent a novel approach using a generative AI model to enhance geographic data (country and institution assignments) for large numbers of samples within SRA datasets. This information can be utilized to bolster public health endeavors.
The indirect relationship between sleep and cognition in the PREVENT cohort: identifying targets for intervention
Authors: Tari Benjamin , Ben Yehuda Michael , Laurell Axel Anders Stefan , Ritchie Karen , Dauvilliers Yves , Ritchie Craig W. , Lawlor Brian , Naci Lorina , Muniz Terrera Graciela , Malhotra Paresh , Watermeyer Tam , Dudas Robert , Underwood Benjamin R. , O'Brien John T. , Raymont Vanessa , Koychev Ivan 
Published: November 2023

IntroductionAs the global population ages, the economic, societal, and personal burdens associated with worsening cognition and dementia onset are growing. It is therefore becoming ever more critical to understand the factors associated with cognitive decline. One such factor is sleep. Adequate sleep has been shown to maintain cognitive function and protect against the onset of chronic disease, whereas sleep deprivation has been linked to cognitive impairment and the onset of depression and dementia.ObjectivesHere, we aim to identify and explore mechanistic links between several sleep parameters, depressive symptoms and cognition in a cohort of middle-aged adults.MethodsWe investigated data from the PREVENT dementia programme via structural equation modeling to illustrate links between predictor variables, moderator variables, and two cognitive constructs (i.e., Executive Function and Memory).ResultsOur model demonstrated that sleep quality, and total hours of sleep were related to participants' depressive symptoms, and that, participant apathy was related to higher scores on the Epworth Sleepiness and Lausanne NoSAS Scales. Subsequently, depressive symptoms, but not sleep or apathy ratings, were associated with Executive Function.ConclusionsWe provide evidence for an indirect relationship between sleep and cognition mediated by depressive symptoms in a middle-aged population. Our results provide a base from which cognition, dementia onset, and potential points of intervention, may be better understood.
Early unrestricted vs. partial weight bearing after uncemented total hip arthroplasty: a systematic review and meta-analysis
Authors: Huang Li , Han Weiyu , Qi Weizhong , Zhang Xiaomeng , Lv Zhou , Lu Yao , Zou Danfeng 
Published: November 2023

BackgroundThe choice of postoperative weight bearing protocol after uncemented total hip arthroplasty (THA) remains controversial. The aim of this study was to assess the efficacy and safety of immediate unrestricted weight bearing (UWB) compared with partial weight bearing (PWB) in patients undergoing uncemented THA.MethodsRelevant articles were retrieved from electronic databases. Both randomized controlled trials (RCTs) and non-RCTs were included but analyzed separately. All functional and clinical outcomes with at least 2 independent study outcomes were meta-analyzed.ResultsA total of 17 studies were investigated. No adverse effect was found regarding micromotion of the femoral stem with immediate UWB following uncemented THA. There was also no correlation between immediate UWB and failure of ingrowth fixation and higher risks of femoral stem subsidence and surgical revision in RCTs. Harris hip score was better in patients with immediate UWB than those with PWB at 1 year post surgery, but the difference was not statistically significant.ConclusionsImmediate UWB did not have extra harm compared with PWB in patients undergoing uncemented THA. UWB was not superior to PWB. Considering the improvement of Harris score and the compliance of patients, UWB can be encouraged in THA rehabilitation.
Ectopic Expression of MADS-Box Transcription Factor VvAGL12 from Grape Promotes Early Flowering, Plant Growth, and Production by Regulating Cell-Wall Architecture in Arabidopsis
Authors: Mao Tingting , Wang Xueting , Gao Hongsheng , Gong Zijian , Liu Ruichao , Jiang Ning , Zhang Yaru , Zhang Hongxia , Guo Xiaotong , Yu Chunyan 
Published: November 2023

The MADS-box family, a substantial group of plant transcription factors, crucially regulates plant growth and development. Although the functions of AGL12-like subgroups have been elucidated in Arabidopsis, rice, and walnut, their roles in grapes remain unexplored. In this study, we isolated VvAGL12, a member of the grape MADS-box group, and investigated its impact on plant growth and biomass production. VvAGL12 was found to localize in the nucleus and exhibit expression in both vegetative and reproductive organs. We introduced VvAGL12 into Arabidopsis thaliana ecotype Columbia-0 and an agl12 mutant. The resulting phenotypes in the agl12 mutant, complementary line, and overexpressed line underscored VvAGL12’s ability to promote early flowering, augment plant growth, and enhance production. This was evident from the improved fresh weight, root length, plant height, and seed production, as well as the reduced flowering time. Subsequent transcriptome analysis revealed significant alterations in the expression of genes associated with cell-wall modification and flowering in the transgenic plants. In summary, the findings highlight VvAGL12′s pivotal role in the regulation of flowering timing, overall plant growth, and development. This study offers valuable insights, serving as a reference for understanding the influence of the VvAGL12 gene in other plant species and addressing yield-related challenges.
O exercício físico no combate à Ansiedade e seu efeito no regulador fisiológico BDNF
Authors: Ribeiro Luiza Helena Mendonça , Sobrinho Marco Aurelio de Souza , Da Silva Gabrielle Alves , Souza Fabiane Gabriele , De Oliveira Junior Manoel Carneiro 
Published: November 2023

Introdução: Considera-se que o exercício físico tem grande importância na promoção de uma vida saudável, sendo responsável por atuar na regulação de aspectos neurológicos e endócrinos, além de ajudar na melhora do condicionamento físico, bem-estar, auxílio na saúde mental e transtornos de ansiedade. O biomarcador envolvido é o fator neurotrófico derivado do cérebro (BDNF), marcador atuante em ações antidepressivas. Metodologia: O presente trabalho é uma revisão integrativa, onde o material utilizado para o levantamento das informações foi obtido através de artigos, livros e revistas, desta maneira, os textos tornaram-se fontes para sua realização. Resultados: Houve a seleção de seis artigos para a exposição dos resultados comparativos com o levantamento das informações sobre indivíduos sedentários e indivíduos que tiveram a transição do estado sedentário para o estado ativo em atividades físicas, onde foram divididos em dois grupos: Alterações fisiológicas significativas (AFS) e Sem alterações fisiológicas significativas (SAF). Discussão: Houve alterações e considerações diferentes entre os autores, como os quatro estudos que obtiveram uma alteração fisiológica significativa frente aos dois a qual identificaram alterações mas não consideraram como significativas, entretanto, todos apontam o exercício físico como um apoio e uma ação secundária no combate a ansiedade, na melhora do bem-estar e qualidade de vida. Conclusão: Concluímos que mesmo com a melhora dos níveis do BDNF e das respostas inflamatórias obtidas após as atividades físicas, o exercício físico não é considerado uma via principal para o tratamento dos transtornos psicológicos.
Prevalência da Cefaléia crônica nos pacientes com diagnóstico de síndrome metabólica acompanhados no Hospital Universitário Alcides Carneiro
Authors: Pessoa José Vitor de Araújo , Gurgel Marcelo Victor Ferreira , De Góes Breno Lucas Bandeira , Pinto Lucas Miná , Duarte Luana Araújo , Chaves Maíra Valéria Ferreira , De Brito Pâmella Eduarda Tavares , Campêlo Maria das Graças Loureiro das Chagas 
Published: November 2023

Cefaleia e síndrome metabólica (SM) são entidades clínicas muito prevalentes e constituem um problema de saúde mundial, ambas causam impacto negativo na qualidade de vida dos seus portadores. A relação entre cefaleia e SM não está totalmente esclarecida e questiona-se se a SM possa ser um fator de risco para cronificação da cefaleia. O objetivo deste estudo foi determinar a prevalência de cefaleia crônica em pacientes com SM. 128 pacientes diagnosticados com SM, atendidos nos ambulatórios de Endocrinologia e/ou Neurologia do HUAC entre março e agosto de 2023, foram incluídos. 72 (56,3%) do gênero feminino e 56 (43,8%) do gênero masculino. A prevalência de cefaleia crônica encontrada foi de 44,5%, sendo que 37(28,9%) tinham Cefaleia do Tipo Tensional (CTT) e 20(15,6%) tinham Migrânea Crônica (MC). Não foi encontrada associação estatisticamente significante entre cefaleia crônica e a SM. A incidência de cefaleia crônica foi maior nas mulheres (F:37; M:20). Trinta e quatro (59,64%) pacientes faziam tratamento profilático para a dor há pelo menos seis meses. Dezoito (31,57%) dos pacientes com cefaleia crônica relataram insatisfação com o tratamento, a associação entre insatisfação com o tratamento e SM foi estatisticamente significante (p<0,05). A prevalência de cefaleia crônica em pacientes com SM foi alta havendo predomínio da cefaleia tensional. Estes resultados sugerem que o controle da SM poderá minimizar o risco de cronificação destas cefaleias. Outros estudos são necessários para melhor elucidar os mecanismos envolvidos nesta associação, a fim de desenvolver novas terapêuticas para estas doenças debilitantes.
Movimentação ortodôntica em dentes tratados endodonticamente: uma revisão integrativa
Authors: Adeodato Tayná da Costa , Vasconcelos Larissa Loures , Gritti Giovana Cunha , Ribeiro Yuri Jivago Silva , Ribeiro Michael Ranniery Garcia 
Published: November 2023

Visto que a aplicação de forças ortodônticas sobre o dente produz reações indesejáveis na estrutura radicular e no periodonto de sustentação, onde a regeneração não ocorre, o conhecimento, por parte do ortodontista, de fatores que levam a este dano tecidual é indispensável para o sucesso do tratamento ortodôntico Dessa forma, essa revisão integrativa da literatura tem como objetivo verificar se ocorrem alterações em dentes tratados endodonticamente que foram submetidos ao tratamento ortodôntico. Trata-se de uma revisão integrativa da literatura. A pergunta norteadora desta pesquisa foi: Ocorrem alterações em dentes tratados endodonticamente que foram submetidos ao tratamento ortodôntico? A busca na literatura ocorreu no mês de maio de 2023 nas bases de dados BVS e PUBMED com o corte temporal de 2012 a 2023. os descritores empregados foram DECs e MESH, sendo incluídos artigos científicos nos idiomas português Brasil, inglês e espanhol, trabalhos disponíveis na íntegra gratuitamente, e de acordo com objetivo proposto, foram excluídos estudos secundários, editoriais e notas ao editor. Os 7 artigos verificaram que os dentes tratados endodonticamente tiveram menos reabsorção radicular do que os dentes vivos sob tratamento ortodôntico, sugerindo aos clínicos que a movimentação ortodôntica de dentes tratados endodonticamente é um procedimento clínico relativamente seguro e que a eficácia na movimentação ortodôntica ocorre tanto para dentes hígidos como dentes tratados endodonticamente. Conclui-se que dentes tratados endodoticamente corresponde a forças ortodônticas de forma semelhante a dentes hígidos e o tratamento endodôntico não afeta o grau de reabsorção radicular durante o tratamento ortodôntico.