bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Consequences of Preterm Birth in the Children of Mothers with Inflammatory Bowel Disease: A Nationwide Cohort Study
Authors: Friedman Sonia , Garvik Olav Sivertsen , Nielsen Jan , Jølving Line Riis , Andersen Mette Louise , Nørgård Bente Mertz 
Published: February 2025

Abstract

Introduction
Mothers with inflammatory bowel disease (IBD) are at increased risk of delivering their infants preterm. In the general population, chronic diseases in adulthood as well as increased morbidity and mortality are associated with being born preterm. We aimed to examine whether this was true for preterm versus full-term infants born to mothers with IBD.

Methods
This is an observational cohort study based on the Danish Health Registries. The study population comprised all live-born singleton children, born to mothers with IBD, during the study period of 1995 through 2016. We estimated the risk of selected chronic diseases in offspring born preterm to mothers with IBD. These included epilepsy, chronic lung disease and asthma, depression and bipolar affective disorder, autism spectrum disorders, schizophrenia/psychosis, attention-deficit hyperactivity disorder, and mental retardation/intellectual disabilities. We adjusted for relevant confounders.

Results
In all, 736 children were born preterm, and 9655 were born full-term to mothers with IBD. The median, 25th, and 75th percentiles of the follow-up time of the children were 11.1 (6.4, 16.3) years and 11.4 (7.3, 16.3) years for the full-term and preterm cohorts, respectively. There was a statistically significant increased risk of mental retardation/intellectual disabilities in preterm versus full-term children (aHR 2.15; 95% CI 1.07-4.36). We also found a non-significantly increased risk of epilepsy (1.11; 0.51-2.42), chronic lung disease and asthma (1.10; 0.76-1.60), schizophrenia/psychosis (1.17; 0.50-2.73), and attention-deficit/hyperactivity disorder 1.15 (0.83-1.60).

Conclusion
Our study indicates the possibility of chronic health consequences in children born preterm to mothers with IBD.
A comparative analysis of consumers’ patterns of reimbursable prescription medications between online-only and community pharmacies
Authors: Olesen Anne Estrup , Simonsen Jacob Herrig , Madsen Susanne Storm , Hansen Rikke Nørgaard , Sørensen Ann Lykkegaard 
Published: February 2025

Abstract

Objectives
Online pharmacies have emerged as a novel method for procuring reimbursable medicines. The study aimed to compare consumers’ patterns of reimbursable prescription medications between online-only and community pharmacies in The North Denmark Region which is one of five regions in Denmark.

Method
The retrospective study used registered data for all reimbursable medicine prescriptions from pharmacies in 2022 across Denmark but specifically retrieved from patients residing in The North Denmark Region.

Key findings
In 2022, 4414 and 395 438 patients obtained reimbursable medicines from 2 online-only and 240 community pharmacies, respectively. The age distribution of patients using online-only pharmacies was significantly different from community pharmacies (P &lt; .001) as the proportion of patients in age groups 30–69 years was higher for online-only pharmacies. Whereas patients above the age of 70 were more likely to fill prescriptions from community pharmacies. The gender distribution of patients using online-only pharmacies was different from community pharmacies (P &lt; .001) as a higher proportion of females filled prescriptions from online-only pharmacies. The distribution of patients’ living areas differed between the two types of pharmacies (P &lt; .001), where the proportion of patients from metropolitan municipalities was higher at online-only pharmacies. The distribution of prescriptions by anatomical therapeutic chemical code differed between the two types of pharmacies (P &lt; .001).

Conclusion
Consumer patterns were different between online-only and community. These insights may inform pharmacy owners, ensuring both online and community pharmacies meet public health needs effectively in the future.
Toward a Holistic Study of Mosques in the US: A Critical Integrative Literature Review and Framework
Authors: Mohammed Hassnaa 
Published: February 2025

ABSTRACT
US mosques have gained considerable scholarly attention, focusing on the contested grounds on which they stand. Although literature on US mosques has been published in different fields, there is no work assessing the current state of research. Given that the number of Muslims is exponentially increasing in the US and the number of mosques increased by 31 percent between 2010 and 2020, synthesizing existing publications may lead to a renewed perspective on ways to study these complex institutions. This study sets forth a systematic critical integrative review of literature published on US mosques in peer-reviewed journals. The study presents overarching trends in publications related to mosques before December of 2022, identifies seven main themes in existing literature, proposes an integrative framework for studying mosques by highlighting global, regional, local, and internal factors that impact mosques’ development, and identifies unanswered questions in the body of literature.
Temperature-dependent parasitism, development, and reproduction of Microplitis manilae (Hymenoptera: Braconidae) on Spodoptera litura (Lepidoptera: Noctuidae)
Authors: Tian Shuang , Di Xue-Yuan , Yan Bin , Yu Yuan-Chan , Ren Peng , Wu Hui-Zi , Yang Mao-Fa 
Published: February 2025

Abstract
The braconid wasp Microplitis manilae (Hymenoptera: Braconidae) is a solitary, koinobiont endoparasitoid of young Spodoptera litura (Fabricius) larvae and one of its most crucial natural parasitic enemies. The establishment of a stable and sufficient population of M. manilae by rearing them in a laboratory is the cornerstone of field release management. However, when reared in a laboratory, M. manilae is affected by temperature. Here, we attempted to optimize the rearing temperature of M. manilae for parasitizing second-instar S. litura larvae by examining the effects of rearing at 5 temperatures: 16 °C, 20 °C, 24 °C, 28 °C, and 32 °C. Our results suggest that the development of the parasitoid progeny speeded up with shorter durations of the egg–larval, pupal, and preadult stages with the increase in temperature from 16°C to 32 °C. The parasitism rate and fecundity of M. manilae upon parasitizing second-instar S. litura larvae increased with rearing temperature from 16°C to 24 °C, with the peaks at 24 °C reaching 52.90% and 111.70 eggs/female, respectively, and then decreased at 28 °C to 32 °C. At 24 °C, the sex ratio (0.22) was the lowest, whereas the emergence rate (68.54%) did not differ significantly compared with those at other temperatures. Meanwhile, at 28 °C, the parasitism rate, fecundity, and emergence rate approached the levels at 24 °C, whereas the sex ratio was higher (0.29) than at 24 °C. These findings suggest 24 °C to 32 °C is the most appropriate temperature range for M. manilae mass rearing under laboratory conditions.
Effects of synergists on the efficacy of long-lasting insecticide-incorporated netting against Tribolium castaneum (Coleoptera: Tenebrionidae) and Rhyzopertha dominica (Coleoptera: Bostrichidae)
Authors: Ming Qinglei , Morrison William R , Zhu Kun Yan , Campbell James F , Scully Erin D 
Published: February 2025

Abstract
Long-lasting insecticide-incorporated netting (LLIN) has been used to deliver pyrethroids for management of stored product insect pests in food facilities. However, the development of resistance to pyrethroids in stored product pests is a widespread and urgent problem, which threatens the efficacy of commercially available LLINs. A potential approach for enhancing LLIN efficacy is the use of insecticide synergists to inhibit detoxification enzymes and exacerbate the effects of pyrethroids. Here, we evaluated the synergistic properties of 3 detoxification enzyme inhibitors—piperonyl butoxide (PBO), diethyl maleate (DEM), and triphenyl phosphate (TPP)—with LLIN against the red flour beetle Tribolium castaneum (Herbst), and the lesser grain borer Rhyzopertha dominica (Fabricius). Pre-exposure to PBO resulted in higher mortality after exposure to LLIN for T. castaneum and R. dominica. With pre-exposure to PBO followed by LLIN exposure, there was a trend for lower LT50 values for both species, while the extent of synergistic effects was greater on R. dominica than T. castaneum. In contrast, with pre-exposure to DEM and TPP followed by LLIN exposure, there were no significant reductions in LT50 values for both species. In addition, the presence of food had a significant effect on the recovery and delayed mortality in T. castaneum and R. dominica, reducing the efficacy of synergist and LLIN in combined exposures. This study provides baseline data towards improving the efficacy of LLIN against stored product pests.
Non-canonical NF-κB signaling in dendritic cells is required for ATP-driven indoleamine 2,3-dioxygenase 1 induction through P2Y11 receptor
Authors: Ocadlikova Darina , Fiordi Benedetta , Trabanelli Sara , Salvestrini Valentina , Ciciarello Marilena , Forte Dorian , Campazzi Emma , Vitali Letizia , Cipollitta Serenella C , Pegoraro Anna , Jandus Camilla , Di Virgilio Francesco , Adinolfi Elena , Cavo Michele , Curti Antonio 
Published: February 2025

Abstract
Extracellular ATP released from dying cells, including tumor cells, is a key mediator of inflammation and tolerance by binding to purinergic receptors on dendritic cells, resulting in inflammasome activation (via P2X7R), dendritic cell maturation (via P2Y11R), and Indoleamine-2,3-dioxygenase 1 upregulation. However, the regulation of ATP-driven Indoleamine-2,3-dioxygenase 1 expression in human dendritic cells has been poorly investigated. In this work we aimed to investigate the ATP-driven molecular regulation of Indoleamine-2,3-dioxygenase 1 expression via purinergic receptors and to provide an in-depth characterization of ATP-driven T regulatory cells induced by Indoleamine-2,3-dioxygenase 1-expressing dendritic cells. We identified P2Y11R as being responsible for ATP-driven Indoleamine-2,3-dioxygenase 1 upregulation, and non-canonical NF-kB as a molecular pathway associated with ATP-dependent Indoleamine-2,3-dioxygenase 1 induction through P2Y11R. Then we investigated - but did not confirm - an involvement of inflammasome machinery through P2X7R in Indoleamine-2,3-dioxygenase 1 upregulation. Finally, we evaluated the role of ATP catabolism via ATP ectonucleotidases, i.e. CD39 and CD73 and its main product adenosine, in regulating the generation of Indoleamine-2,3-dioxygenase 1-driven T regulatory cells. We found that ATP-driven Indoleamine-2,3-dioxygenase 1 upregulation is associated with CD73 upregulation and adenosine production. Additionally, ATP-treated Indoleamine-2,3-dioxygenase 1-positive mature dendritic cells induce PD-1-expressing bone fide suppressive T regulatory cells via adenosine A2AR. Collectively, a more in-depth understanding of ATP-driven immune-regulatory mechanisms through Indoleamine-2,3-dioxygenase 1 regulation in human dendritic cells leading to the induction of T regulatory cells can have clinical implications for the development of Indoleamine-2,3-dioxygenase 1 inhibitors in cancer patients, especially in combination with immunotherapy such as an anti-CD73 or adenosine receptor agonist and immunogenic chemotherapy.
Mussel Goo as Glue
Authors: Jerome W Gray (Jay) 
Published: February 2025

Abstract
Skin grafting is a critical component for healing damaged skin when the damage is extensive. Engraftment requires adhering replacement tissue over the damaged area. Traditional adherence methods, such as stapling or suturing the replacement in place, can produce additional damage and complicate healing. Researchers at Pohang University of Science and Technology have developed an adhesive mixture with superior properties for attaching skin grafts and promoting wound healing. The mixture is based on polymers derived from mussels.
Enhancing the Performance of Benchtop Transmission Electron Microscopes in Noisy Environments
Authors: McMahon Jim 
Published: February 2025

Abstract
The world’s only benchtop transmission electron microscope (TEM), from Delong Instruments, combines high-contrast imaging with nanoscale resolving power. The low-voltage electron microscope can operate in four imaging modes: TEM; scanning EM (SEM); scanning transmission EM (STEM); and electron diffraction; without having to realign the column or adjust the sample, allowing both surface and transmission images of a sample to be captured from the same area of interest. Negative-stiffness vibration isolation enhances the performance of the instrument in vibration-challenged noisy environments.
12-Year-old girl with systemic lupus erythematosus complicated by gangrene and intermittent claudication
Authors: Uechi Takashi , Horinouchi Tomoko , Inoki Yuta , Tanaka Yu , Kitakado Hideaki , Ueda Chika , Nagano China , Yamaguchi Masato , Tsuji Yoriko , Nozu Kandai 
Published: February 2025

ABSTRACT
Systemic lupus erythematosus (SLE) can present with various symptoms, including rare manifestations such as gangrene. This report describes a 12-year-old girl with SLE who presented with intermittent claudication and gangrene. Although intermittent claudication is rare in paediatric cases, it is essential to consider vascular diseases including those associated with SLE as a potential cause. The patient initially experienced pain, redness, and cold sensations in the right great toe accompanied by intermittent claudication, with symptoms worsening over time. Diagnostic imaging, including contrast-enhanced computed tomography and magnetic resonance imaging, revealed occlusion of the right popliteal artery with associated vasculitis and thrombosis. The diagnosis of SLE and antiphospholipid syndrome was confirmed based on clinical criteria. Treatment included prednisone, methylprednisolone pulse therapy, mycophenolate mofetil, hydroxychloroquine, and anticoagulants. The patient showed significant improvement, with resolution of claudication and effective management of her gangrene through immunosuppressive therapy and careful wound care. This case highlights the importance of considering vascular complications in paediatric SLE and underscores the need for early diagnosis and comprehensive treatment.
Intrathecal Sintilimab for Leptomeningeal Metastases of Non-small Cell Lung Cancer Failed from Targeted Therapy and Intrathecal Chemotherapy (LMIS study)
Authors: Fan Chengjuan , Hu Yuanyuan , Teng Chong , Lv Yanju , Song Xiaowei , Shen Weixi , Jiang Qiuying , Huang Dayong , Du Lina , Wang Guohua , Du Yang , Man Siqi , Zhang Zhichao , Zhang Jing , Li Li , Xin Tao 
Published: February 2025

Abstract

Backgroud
Leptomeningeal metastases (LMs) are serious complications of non-small cell lung cancer (NSCLC). This study aimed to investigate the safety and efficacy of intrathecal immune checkpoint inhibitors (ICIs) in treating NSCLC-LM.

Methods
We conducted this prospective phase 1 study (ChiCTR2200062245) using a traditional "3 + 3" design with intrathecal sintilimab (dose escalation 10mg, 20mg, 30mg, and 40mg) for NSCLC-LM patients who had progressed from targeted therapy and intrathecal pemetrexed. The primary study endpoints were safety and recommended dose, and the secondary endpoints included clinical response rate, progression-free survival (PFS), intracranial progression-free survival (iPFS), and overall survival (OS).

Results
No dose-limiting toxicity was found at 10mg, 20mg, 30mg, and 40mg for intrathecal sintilimab. Therefore, sintilimab 40mg was recommended for intrathecal injection. A total of 19 patients were enrolled in this study. The median age at diagnosis of LM was 53 years. The overall incidence of adverse events (AEs) was 68.4%, and rash (n=4, 21.1%) was the most common AEs, which returned to normal after symptomatic treatment. As 1 patient was lost to follow-up and 18 patients could be evaluated for efficacy, the clinical response rate was 38.9% (7/18). Median PFS was 3.5 months (95% CI: 2.7-4.2 months), median iPFS was 3.5 months (95% CI: 1.3-5.6 months), and median OS was 11.5 months (95% CI: 0.0-25.4 months).

Conclusions
Intrathecal ICIs for NSCLC-LM patients are safe, and the recommended dose of sintilimab is 40mg. Intrathecal sintilimab for NSCLC-LM failed from multi-line therapies, showed potential effectiveness in some patients, and is worthy for further study.
Quantifying antimicrobial disposals at six community pharmacies with longitudinal medication disposal programs: an underappreciated component of a One Health approach to antimicrobial stewardship
Authors: Hoskins Elizabeth , Bickenbach Elizabeth M , Buchanan Margaret , Detter Steve , Ferguson Michael , Freeman Ahunna , Hoskins Ryan , Johnston Aaron , Lee Robbin , Marks Brian , Weger Brittany R , Bradley Courtney L , Smith Jordan R , Carlson Travis J 
Published: February 2025

Abstract

Background
Unused, unwanted, and expired (UUE) medications, including antibiotics, pose a risk to our patients, their families, and our environment. A One Health approach to antimicrobial stewardship calls for stewards to recognize the interconnection between humans and our shared environment. The aims of this project were twofold: 1) educate community members about the importance of responsible medication disposal and 2) quantify the UUE medications returned to community pharmacies.

Methods
Medication disposal programs were established at several community pharmacies in central North Carolina. Periodically, pharmacy school faculty and students visited the participating pharmacies to identify, quantify, and dispose of all UUE medication returns. Medications were deactivated using a Deterra® Multi-purpose or Rx Destroyer™ All-purpose Disposal System and disposed of in accordance with product instructions and applicable laws and regulations.

Results
Between November 2021 and May 2023, six community pharmacies maintained longitudinal medication disposal programs. In total, 144,084 UUE prescription medication tablets/capsules containing approximately 19.3 kg of active pharmaceutical ingredient (API) were disposed of. Antimicrobials accounted for 2.6% of all tablets/capsules and nearly 1.3 kg (6.6%) of API. The most disposed antibiotics were doxycycline, amoxicillin, clindamycin, cephalexin, and ciprofloxacin.

Conclusions
In this geographically limited study, nearly 1.3 kg of antimicrobial API was disposed of in a span of one and a half years. Recognizing antimicrobial disposal as an important component of a One Health approach to antimicrobial stewardship, with the goal of expanding these efforts, may influence antimicrobial resistance in our environment.
Governance of Generative AI
Authors: Taeihagh Araz 
Published: February 2025

Abstract
The rapid and widespread diffusion of generative artificial intelligence (AI) has unlocked new capabilities and changed how content and services are created, shared, and consumed. This special issue builds on the 2021 Policy and Society special issue on the governance of AI by focusing on the legal, organizational, political, regulatory, and social challenges of governing generative AI. This introductory article lays the foundation for understanding generative AI and underscores its key risks, including hallucination, jailbreaking, data training and validation issues, sensitive information leakage, opacity, control challenges, and design and implementation risks. It then examines the governance challenges of generative AI, such as data governance, intellectual property concerns, bias amplification, privacy violations, misinformation, fraud, societal impacts, power imbalances, limited public engagement, public sector challenges, and the need for international cooperation. The article then highlights a comprehensive framework to govern generative AI, emphasizing the need for adaptive, participatory, and proactive approaches. The articles in this special issue stress the urgency of developing innovative and inclusive approaches to ensure that generative AI development is aligned with societal values. They explore the need for adaptation of data governance and intellectual property laws, propose a complexity-based approach for responsible governance, analyze how the dominance of Big Tech is exacerbated by generative AI developments and how this affects policy processes, highlight the shortcomings of technocratic governance and the need for broader stakeholder participation, propose new regulatory frameworks informed by AI safety research and learning from other industries, and highlight the societal impacts of generative AI.
A new obstacle for phenomenal contrast
Authors: Fulkerson Matthew , Cohen Jonathan 
Published: February 2025

Abstract
Phenomenal Contrast Arguments (PCAs) are a prominent method in philosophy of mind for, among other uses, investigating how specific mental features shape the phenomenal character of experience. This paper identifies a general and underexplored obstacle to the success of PCAs: The necessity of demonstrating that the contrasts employed in these arguments are genuinely phenomenal, rather than merely cognitive or otherwise non-phenomenal. We contend that proponents of PCAs often assume a phenomenal difference without adequately ruling out these alternative explanations for the available contrast. While we do not preclude the possibility of successful PCAs, our arguments suggest that many existing instances fail to meet this burden.
A New Copy of Shakespeare’s Sonnet 116: A Cavalier Cover Version
Authors: Veronese Leah S 
Published: February 2025

Abstract
This article records a new witness of Shakespeare’s Sonnet 116 in Bodleian MS Ashmole 36, 37. The poem is a copy of Henry Lawes’ song-setting which adds six new lines to the poem. The song-setting can also be found in NYPL Drexel MS 4257, although there are significant variations between the two copies. The sonnet takes on new political relevance when read in the context of the Royalist Elias Ashmole’s miscellany, Bodleian MS Ashmole 36, 37, amongst material from the early 1640s: Shakespeare’s text is transformed from praise of romantic constancy to political constancy. This article provides a transcription of the new witness, reads the text in the local context of Bodleian MS Ashmole 36, 37, and then considers the setting in the wider context of the circulation of Shakespearean songs in manuscript and domestic musical performance during the Interregnum. The text is politicized at a local level in the context of Bodleian MS Ashmole 36, 37 and in the wider context of domestic performance during the Interregnum when the public performance of music was banned. This new copy contributes to our understanding of the circulation of Shakespeare’s poetry in manuscript, Shakespearean reception during the mid-seventeenth century, and Royalist counterculture.