bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interspecific hybridization of decapod crustacean species with commercial interest—A review
Authors: Syafaat Muhammad Nur , Abualreesh Muyassar H. , Yatim Norhafiza Ilyana , Fazhan Hanafiah , Waiho Khor , Ma Hongyu , Okomoda Victor Tosin , Ikhwanuddin Mhd 
Published: October 2023

AbstractInterspecies hybridization has been widely used in the development of aquaculture in fish species but there is not much impact in crustacean species. Several species of crustaceans that have been successfully crossed still have low hatching rates and the hybrids obtained have not met expectations. This review tries to summarize and analyse interspecific hybridization of cultured crustacean species (shrimps, lobsters, crayfish and crabs) and its potential for development of crustacean aquaculture production. The success of cross‐breeding on several species of shrimp and lobster has been supported by artificial insemination technology. In crabs, artificial insemination cannot be applied and cross‐breeding still relies on natural mating with an unstable success rate. In addition to cross‐breeding in captivity, cross‐breeding of crustacean species (shrimp, lobster, crayfish and crab) in nature has also been found. Interbreeding of crustacean species in nature cannot always be distinguished morphologically, hybrids between them can be known with certainty after carrying out molecular analysis. Even though the level of reproductive performance in cross‐breeding of shrimp, lobster, crayfish and crab species is still low, cross‐breeding efforts must be continued to obtain more information so that it can later be mapped which species have the potential to develop hybrids for cultivation. Furthermore, growth, reproductive performance, monosex hybridity and disease resistance are all hybrid parameters that must be evaluated.
Clinical features and outcomes of small airway disease in ANCA‐associated vasculitis
Authors: Zhou Peining , Gao Li , Li Zhiying , Que Chengli , Li Haichao , Ma Jing , Wang Guangfa 
Published: October 2023

AbstractBackground and ObjectiveTo clarify the prevalence, features and outcomes of small airway disease (SAD) in a Chinese cohort with antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) related pulmonary involvement.MethodsSAD was recorded when the manifestations of either centrilobular nodules or air trapping were observed according to CT scans, except for infection or other airway‐related comorbidities. Baseline and follow‐up data were collected retrospectively.ResultsOf the 359 newly diagnosed AAV patients with pulmonary involvement, 92 (25.6%) had SAD, including 79 (85.9%) cases of anti‐MPO‐ANCA positive, 9 (9.8%) cases of anti‐PR3‐ANCA positive and 2 (2.2%) cases of double positive. Patients with SAD were more likely to be younger, female, non‐smokers, have more ear–nose–throat (ENT) involvement, and have higher baseline Birmingham Vasculitis Activity Score (BVAS) compared to patients without SAD. Several AAV‐related SAD patients have improved lung function and CT scans after immunosuppressive therapy. Patients with SAD had a better prognosis compared to those without SAD. When dividing all patients into three groups: isolated SAD (only small airway involvements), SAD with other lower airway involvements, and non‐SAD, patients in the SAD with other lower airway involvements group had the highest risk of infection, while patients in the non‐SAD group had the worst long‐term outcomes. Similar results were observed in anti‐MPO‐ANCA positive patients when performing subgroup analyses.ConclusionSAD is a unique manifestation of AAV‐related lung involvement and exhibits distinct clinical features. It is vital to focus on SAD because of its association with prognosis and infection in AAV patients, especially in anti‐MPO‐ANCA positive patients. Moreover, SAD might represent a better response to immunosuppressors.
New insights into the palaeoenvironmental–palaeoclimatic significance and sedimentary dynamics of carbonate Lagerstätten: The lower Albian of Pietraroja (Southern Italy)
Authors: Graziano Roberto , Raspini Arturo , Bartiromo Antonello 
Published: October 2023

AbstractThis study reports the first high‐resolution, integrated facies analysis of the lowermost Albian Pietraroja Lagerstätten (Apennine Carbonate Platform) which yields the first dinosaur (Scipionyx samniticus) found in Italy and other terrestrial vertebrates and plants. Aiming to clarify the long‐debated palaeoenvironmental significance of the Pietraroja succession, the following have been carried out: (i) a field survey to establish stratigraphic position and number of the fossil Lagerstätten; (ii) the centimetre‐scale facies analysis of a new section, ca 15 m thick, consisting of two new lithostratigraphic units, the ‘Cyclically organized Limestones’ and the ‘Cherty Limestones’; (iii) the scanning electron microscopy – energy dispersive X‐ray spectroscopy and backscattered electron – energy dispersive X‐ray spectroscopy analyses of clay mineral proxies for palaeoclimate and non‐carbonate grains; and (iv) the regional and supra‐regional investigation of the event stratigraphical context of the fossil Lagerstätten, in order to elucidate the controls on their formation. The section includes two out of the three observed fossil‐rich Lagerstätten, each up to 1.5 m thick. The arrangement of lithofacies and early diagenetic overprint defines shallow‐water depositional cycles suggestive of precession and short‐eccentricity periodicities. The Middle Lagerstätte yielding Scipionyx samniticus consists of three intervals. The lower, paralic interval was deposited during arid conditions and passes gradually to the plant‐rich, coastal wetland carbonaceous marls of the upper interval. The ‘Cherty Limestones’, yielding the Upper Lagerstätte with terrestrial vertebrates, contains two spiculitic intervals suggesting the development of siliceous sponge meadows in a shallow, restricted lagoon. Genetic stratigraphy suggests that the Pietraroja Lagerstätten were formed during glacioeustatic lowstands; interestingly, the Middle Lagerstätte mirrors the earliest Albian sea‐level lowstand (KAl1 event, ca 111.2 Myr), during a semi‐continuous supply of windblown volcaniclastics. Findings herein substantiate the pivotal role of paralic–continental Lagerstätten for deriving high‐frequency palaeoclimatic dynamics and glacioeustacy from carbonate platform archives. The origin of Tethyan continental bridges between Africa and Europe during the late Aptian–earliest Albian cold interval is discussed.
Pleistocene glaciomarine laminated muds in the Central Basin of the northwestern Ross Sea and their palaeoceanographic records
Authors: Khim Boo‐Keun , Sohn Young Kwan , Lee Min Kyung , Kim Sunghan , Lee Jae Il , Yoo Kyu Cheul 
Published: October 2023

AbstractGlaciomarine laminated muds around the Antarctic continental margin are important in the marine geological record related to ice sheet dynamics. Microscopic observation and backscattered electron imagery of Pleistocene laminated muds in the Central Basin (Ross Sea) reveal that the light laminae comprise terrigenous angular to subangular silt‐sized particles, scattered diatom fragments, and eroded sand‐sized lumps of fossil‐bearing mud. In contrast, the dark laminae are clayey and biogenic with very tiny pieces of fossils. These laminated muds are interpreted to have been deposited by subglacial meltwater plumes underneath the advancing glaciers that torn off the earlier‐deposited and semi‐consolidated diatom‐rich sediments. Thus, most biogenic components of these laminated muds were recycled from older deposits, indicating that they are not related to enhanced biological production during the mud deposition. Our study suggests that the recycling of biogenic particles should be considered when interpreting the palaeoclimatic and palaeoceanographic implications of Antarctic environmental system.
Knowledge‐guided digital twin modeling method of generating hierarchical scenes for a high‐speed railway
Authors: Zhang Heng , Zhao Wen , Han Zujie , Zhu Jun , Zhu Qing , Xu Zhu , Feng Dejun , Song Yongjun , Song Shufeng , Zhang Bo , Jia Fengpin , Xie Yakun , Quan Yushan , Zhang Junhu , Li Weilian 
Published: October 2023

AbstractChina's railway construction is rapidly transitioning toward integrated management of “stakeholders, management elements, and management processes”. Therefore, comprehensive and whole‐process digital twin scene modeling is urgently needed for intelligent railway construction. However, the requirements of three‐dimensional scenes in different stages vary hierarchically, resulting in a lack of construction semantics and limited universality in modeling. This article proposes a knowledge‐guided digital twin modeling method of hierarchical scenes for a high‐speed railway. We first build a knowledge graph of “knowledge‐model‐data” to achieve an accurate and hierarchical description of railway scenes. We then establish a parameter‐driven modeling method that integrates knowledge guidance and primitive combination to generate a display scene and a virtual design scene automatically. Third, we propose joint linkage and model growth methods for construction action modeling, which are used to generate a virtual construction scene. Finally, in response to the hierarchical scene‐generating requirements in different stages, we conduct intelligent modeling experiments for the entire design and construction process. The knowledge graph of the hierarchical semantic description mode significantly improves the flexibility and universality of the modeling method. The proposed modeling method for the entire process contributes to the rapid representation of design data, in‐depth design, visual exploration, and dynamic optimization of the construction process. This article provides a reliable digital twin modeling solution for the entire process to improve design and construction quality.
A focus on progestogens in hormone replacement therapy
Authors: Ghosh Srirupa , Imrie Rachel , Goadsby James , Savvas Michael 
Published: October 2023

Key content

Women receiving estrogen replacement require concomitant progestogen to prevent endometrial hyperplasia and carcinoma.

A variety of progestogens are used in hormone replacement therapy (HRT), with different advantages and disadvantages and routes of administration.

Progestogenic side effects may be mild but can be debilitating and lead to the discontinuation of HRT, so progestogens should be tailored to the individual woman.

Combined HRT containing estrogen and progestogens may be associated with a small increase in the absolute risk of breast cancer, which is not seen in women taking estrogen alone. However, this risk is small, particularly when compared with other modifiable lifestyle risk factors.

The addition of certain progestogens to estrogen in the long term may be associated with an increased risk of heart disease, breast cancer and dementia.

Learning objectives

To understand relative advantages and disadvantages of the different progestogens, regimens and routes of administration.

To be aware of current evidence for types, dose and routes of administration of different progestogens.

To be able to prescribe progestogens safely in terms of side effect and risk profiles that are individualised to the patient.

Ethical issues

Well‐informed counselling including absolute, individualised risks for women considering HRT with a progestogenic component is essential to allow patients to make well‐informed choices.
An unsupervised learning approach to identify immunoglobulin utilization patterns using electronic health records
Authors: Riazi Kiarash , Ly Mark , Barty Rebecca , Callum Jeannie , Arnold Donald M. , Heddle Nancy M. , Down Douglas G. , Sidhu Davinder , Li Na 
Published: October 2023

AbstractBackgroundManaging Canada's immunoglobulin (Ig) product resource allocation is challenging due to increasing demand, high expenditure, and global shortages. Detection of groups with high utilization rates can help with resource planning for Ig products. This study aims to uncover utilization subgroups among the Ig recipients using electronic health records (EHRs).MethodsThe study included all Ig recipients (intravenous or subcutaneous) in Calgary from 2014 to 2020, and their EHR data, including blood inventory, recipient demographics, and laboratory test results, were analyzed. Patient clusters were derived based on patient characteristics and laboratory test data using K‐means clustering. Clusters were interpreted using descriptive analyses and visualization techniques.ResultsAmong 4112 recipients, six clusters were identified. Clusters 1 and 2 comprised 408 (9.9%) and 1272 (30.9%) patients, respectively, contributing to 62.2% and 27.1% of total Ig utilization. Cluster 3 included 1253 (30.5%) patients, with 86.4% of infusions administered in an inpatient setting. Cluster 4, comprising 1034 (25.1%) patients, had a median age of 4 years, while clusters 2–6 were adults with median ages of 46–60. Cluster 5 had 62 (1.5%) patients, with 77.3% infusions occurring in emergency departments. Cluster 6 contained 83 (2.0%) patients receiving subcutaneous Ig treatments.ConclusionThe results identified data‐driven segmentations of patients with high Ig utilization rates and patients with high risk for short‐term inpatient use. Our report is the first on EHR data‐driven clustering of Ig utilization patterns. The findings hold the potential to inform demand forecasting and resource allocation decisions during shortages of Ig products.
OPTIMAL BLUETOOTH LOW ENERGY (BLE) SYSTEM DEPLOYMENT STRATEGY PRIOR TO SYSTEM APPLICATION ON THE CONSTRUCTION SITE
Authors: Tsu Yian Lee , Ahmad Faridahanim , Sarijari Mohd Adib 
Published: October 2023

The application of Bluetooth Low Energy (BLE) systems for labour tracking on construction sites is a popular research trend. Strategic system deployment is crucial for ensuring the overall reliability and feasibility of these systems. This study aims to identify the optimal BLE system deployment strategy for tiling work zones in three different renovation sites. The BLE system consists of BLE beacon, BLE gateway, Raspberry Pi (data logger), and MATLAB for data analysis. To ensure optimal placement of the BLE gateway, site visits were conducted to evaluate various conditions, such as power supply availability, signal blockage by structures, and potential disruption to the tiling work. In addition, the beacon transmission (Tx) levels were adjusted to enhance the detection accuracy of the system. The findings show that the optimum beacon Tx powers at sites A, B, and C are -12dBm (86.3% accuracy), -16dBm (94.6% accuracy), and -16dBm (91.1% accuracy), respectively. These findings will be adopted in future research on these sites. The study contributes to the understanding of optimal BLE system deployment strategies in construction sites, which can improve labour tracking accuracy and overall project management.
LRBA signalosomes activate vasopressin‐induced AQP2 trafficking at recycling endosomes
Authors: Yanagawa Hideki , Hara Yu , Ando Fumiaki , Suzuki Soichiro , Fujiki Tamami , Oikawa Daisuke , Yui Naofumi , Mandai Shintaro , Mori Yutaro , Susa Koichiro , Mori Takayasu , Sohara Eisei , Tokunaga Fuminori , Uchida Shinichi 
Published: October 2023

AbstractAquaporin‐2 (AQP2) water channels are proteins that are recycled between intracellular vesicles and the apical plasma membrane in renal collecting ducts. Lipopolysaccharide‐responsive beige‐like anchor protein (LRBA) is a protein kinase A (PKA) anchoring protein that creates compartmentalized PKA signalling responsible for AQP2 phosphorylation. In response to increased plasma osmolality, vasopressin/cyclic adenosine monophosphate (cAMP)/PKA signalling phosphorylates AQP2, promoting AQP2 trafficking into the apical plasma membrane and increasing water reabsorption from urine. However, the molecular mechanisms by which LRBA mediates vasopressin‐induced AQP2 phosphorylation remain unknown. To investigate AQP2 intracellular localization and phosphorylation statusin vivo, a density gradient ultracentrifugation technique was combined with anin situproximity ligation assay, super‐resolution structured illumination microscopy and immunoelectron microscopy. Most of the AQP2 was localized on the recycling endosome in the presence of tolvaptan, a vasopressin type 2 receptor (V2R) antagonist. Desmopressin, a V2R agonist, phosphorylated AQP2, translocating it from the recycling endosome to the apical plasma membrane. In contrast, LRBA was constitutively localized at the recycling endosome. Therefore, LRBA and AQP2 were well colocalized in the absence of vasopressin stimulation. The loss of LRBA/PKA signalling byLrbaknockout impaired vasopressin‐induced AQP2 phosphorylation, resulting in AQP2 retention at the recycling endosome. Defective AQP2 trafficking caused low urinary concentrating ability inLrba−/−mice. The LRBA‐PKA complex created compartmentalized PKA signalling at the recycling endosome, which facilitated AQP2 phosphorylation in response to vasopressin.imageKey pointsMembrane proteins are continuously internalized into the endosomal system via endocytosis, after which they are either recycled back to the plasma membrane or degraded at the lysosome.In T cells, lipopolysaccharide‐responsive beige‐like anchor protein (LRBA) binds directly to the cytotoxic T lymphocyte antigen 4 (CTLA‐4), a checkpoint immune molecule, to prevent CTLA‐4 lysosomal degradation and promote its vesicle recycling.LRBA has different physiological functions in renal collecting ducts. LRBA and aquaporin‐2 (AQP2) water channels were colocalized on the recycling endosomein vivoin the absence of the anti‐diuretic hormone vasopressin.LRBA promoted vasopressin‐induced AQP2 trafficking, increasing water reabsorption from urine via AQP2. LRBA determined renal responsiveness to vasopressin at recycling endosomes.LRBA is a ubiquitously expressed anchor protein. LRBA signalosomes might regulate membrane trafficking of several constitutively recycled proteins at recycling endosomes.
Simulation of Pitting Corrosion Under Stress Based on Cellular Automata and Finite Element Method
Authors: Wang Ying , Shi Haoran 
Published: October 2023

Abstract
A new cellular automaton (CA) program was written in python language to simulate the random pitting evolution process, which can not only obtain a variety of different corrosion products but also obtain a variety of common corrosion morphologies on the surface of metal pipes, bridge steel members, etc. In addition, commercial finite element (FE) software abaqus was redeveloped using python scripting language, and the FE mesh with the same size as the cellular mesh was established based on the consistent mesh algorithm, which ensured the efficiency and accuracy of the cyclic iterative algorithm. The stress and strain fields were calculated in real-time by applying the force load, the dissolution probability parameter P was updated in python according to the force-chemical coupling model, and a new corrosion morphology was obtained in python. At the same time, the birth and death element method was applied in abaqus to kill the corrosion elements in this iterative step simultaneously, and the new stress-strain field was recalculated in abaqus. The established consistent grid modeling strategy and cyclic iterative algorithm can significantly improve the solving efficiency of pitting evolution under the coupled action of corrosive medium and load. The results show that the stress concentration caused by pit expansion and the corrosion acceleration effect dominated by plastic deformation will promote each other, leading to the continuous growth of pitted pits. The established modeling strategy and cyclic iterative algorithm can significantly improve the solving efficiency of pitting evolution under the coupled action of corrosive medium and load.
Thermal Performance Improvement of a Spiral Channel Solar Air Heater: Numerical and Experimental Investigation in the Desert Climate of Gabes Region
Authors: Ben Amara Walid , Bouabidi Abdallah , Chrigui Mouldi 
Published: October 2023

Abstract
This study focuses on improving the thermal performance of a solar air heater (SAH) using a single-pass spiral-shaped ducts. The SAH is designed and tested under prevailing weather conditions of Gabes, Tunisia (33°52.8876′ N,10°5.892′ E). The experimental measurements are carried out over 4 days. Similarly, a computational fluid dynamics (CFD) model was developed to study the fluid flow and the heat transfer inside the SAH using the commercial software ansys fluent 2021 R1”. The discrete ordinate (DO) radiation model and the k-ω shear stress transport (SST) turbulence model are used to study the radiative heat transfer and the turbulent flow in the SAH, respectively. The numerical model is validated against experimental data, and the average error does not exceed 3.6%. To improve the heat transfer phenomena, the ratio of horizontal baffle spacing “d” to vertical baffle spacing “p” (d/p) is numerically investigated. Moreover, the highest air outlet temperature during the test days reached 81.1 °C under a mass flowrate of 0.0077 kg/s. The maximum efficiencies are 57%, 54%, 49%, and 46% for the configurations d/p = 1.5, d/p = 2, d/p = 1, and d/p = 0.5 under a mass flowrate of 0.02 kg/s, respectively. The SAH design with d/p = 1.5 is about 4–10% more efficient than the standard design with d/p = 1 under a mass flowrate ranging from 0.0077 kg/s to 0.025 kg/s.
Sensor Data Protection Through Integration of Blockchain and Camouflaged Encryption in Cyber-Physical Manufacturing Systems
Authors: Shi Zhangyue , Oskolkov Boris , Tian Wenmeng , Kan Chen , Liu Chenang 
Published: October 2023

Abstract
The advancement of sensing technology enables efficient data collection from manufacturing systems for monitoring and control. Furthermore, with the rapid development of the Internet of Things (IoT) and information technologies, more and more manufacturing systems become cyber-enabled, facilitating real-time data sharing and information exchange, which significantly improves the flexibility and efficiency of manufacturing systems. However, the cyber-enabled environment may pose the collected sensor data with high risks of cyber-physical attacks during the data and information sharing. Specifically, cyber-physical attacks could target the manufacturing process and/or the data transmission process to maliciously tamper the sensor data, resulting in false alarms or failures in anomaly detection in monitoring. In addition, cyber-physical attacks may also enable illegal data access without authorization and cause the leakage of key product/process information. Therefore, it becomes critical to develop an effective approach to protect data from these attacks so that the cyber-physical security of the manufacturing systems can be assured in the cyber-enabled environment. To achieve this goal, this paper proposes an integrative blockchain-enabled data protection method by leveraging camouflaged asymmetry encryption. A real-world case study that protects the cyber-physical security of collected sensor data in additive manufacturing is presented to demonstrate the effectiveness of the proposed method. The results demonstrate that malicious tampering could be detected in a relatively short time (less than 0.05 ms), and the risk of unauthorized data access is significantly reduced as well.