bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antitumor efficacy of silver nanoparticles reduced with β-D-glucose as neoadjuvant therapy to prevent tumor relapse in a mouse model of breast cancer
Authors: Franco Molina Moisés Armides , Reding Hernández David , García Coronado Paola Leonor , Kawas Jorge R. , Zárate Triviño Diana G. , Hernández Martínez Sara Paola , Castro Valenzuela Beatriz Elena , Rodríguez Padilla Cristina 
Published: January 2024

Introduction: Neoadjuvant therapy constitutes a valuable modality for diminishing tumor volume prior to surgical resection. Nonetheless, its application encounters limitations in the context of recurrent tumors, which manifest resistance to conventional treatments. Silver nanoparticles (AgNPs) have emerged as a promising alternative for cancer treatment owing to their cytotoxic effects.Methods: Cellular viability was assessed by Alamar blue assay in 4T1 breast cancer cell line. Silver biodistribution was detected by an inductively coupled plasma optical emission spectrometer in an in vivo mice model. For neoadjuvant evaluation, mice were randomized and treated intratumoral with AgNPs-G or intraperitoneally with doxorubicin (DOX) as a control. Recurrence was determined after 170 days by counting lung metastatic nodules (dyed with Bouin solution) with histological confirmation by H&amp;E. Masson’s stain, Ki67 immunohistochemistry, and a TUNEL assay were performed in lungs from treated mice.Results: AgNPs-G reduced 4T1 cell viability and in an ex vivo assay the AgNPs-G decreased the tumor cell viability. After intravenous administration of AgNPs-G were detected in different organs. After intratumor administration, AgNPs-G are retained. The AgNPs-G treatment significantly reduced tumor volume before its surgical resection. AgNPs-G reduced the development of lung metastatic nodules and the expression of Ki67. TUNEL assay indicated that AgNPs-G didn’t induce apoptosis.Conclusions: We concluded that intratumor administration of AgNPs-G reduced tumor volume before surgical resection, alongside a reduction in lung metastatic nodules, and Ki67 expression. These findings provide valuable insights into the AgNPs-G potential for intratumor and neoadjuvant cancer therapies. However, further research is needed to explore their full potential and optimize their use in clinical settings.
Prediction of initial objective response to drug-eluting beads transcatheter arterial chemoembolization for hepatocellular carcinoma using CT radiomics-based machine learning model
Authors: Zhang Xueying , He Zijun , Zhang Yucong , Kong Jian 
Published: January 2024

Objective: A prognostic model utilizing CT radiomics, radiological, and clinical features was developed and validated in this study to predict an objective response to initial transcatheter arterial chemoembolization with drug-eluting beads (DEB-TACE) for hepatocellular carcinoma (HCC).Methods: Between January 2017 and December 2022, the baseline clinical characteristics and preoperative and postoperative follow-up imaging data of 108 HCC patients who underwent the first time treatment of DEB-TACE were analyzed retrospectively. The training group (n = 86) and the validation group (n = 22) were randomly assigned in an 8:2 ratio. By logistic regression in machine learning, radiomics, and clinical-radiological models were constructed separately. Finally, the integrated model construction involved the integration of both radiomics and clinical-radiological signatures. The study compared the integrated model with radiomics and clinical-radiological models using calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA).Results: The objective response rate observed in a group of 108 HCC patients who received initial DEB-TACE treatment was found to be 51.9%. Among the three models, the integrated model exhibited superior predictive accuracy in both the training and validation groups. The training group resulted in an area under the curve (AUC) of 0.860, along with sensitivity and specificity values of 0.650 and 0.913, respectively. Based on the findings from the validation group, the AUC was estimated to be 0.927. Additionally, it was found that values of sensitivity and specificity were 0.875 and 0.833, respectively. In the validation group, the AUC of the integrated model showed a significant improvement when contrasted to the clinical-radiological model (p = 0.042). Nevertheless, no significant distinction was observed in the AUC when comparing the integrated model with the radiomics model (p = 0.734). The DCA suggested that the integrated model demonstrates advantageous clinical utility.Conclusion: The integrated model, which combines the CT radiomics signature and the clinical-radiological signature, exhibited higher predictive efficacy than either the radiomics or clinical-radiological models alone. This suggests that during the prediction of the objective responsiveness of HCC patients to the first DEB-TACE treatment, the integrated model yields superior outcomes.
Effects of ethephon on heartwood formation and related physiological indices of Dalbergia odorifera T. Chen
Authors: Zhu Yuan-Jing , Li Jia-Wen , Meng Hui , He Wen-Jie , Yang Yun , Wei Jian-He 
Published: January 2024

IntroductionDalbergia odorifera T. Chen, known as fragrant rosewood, is a rare and endangered tree species. Studies have shown that plant growth regulators can effectively promote heartwood formation. This study aimed to investigate the effects of ethephon (ETH) on heartwood formation and the influence of ethephon and hydrogen peroxide (H2O2) on the physiological characteristics in D. odorifera.MethodsD. odorifera branches underwent treatment with 2.5% plant growth regulators, including ETH, jasmonic acid (JA), salicylic acid (SA), abscisic acid (ABA), H2O2, and inhibitors such as ascorbic acid (AsA) to inhibit H2O2 synthesis, and (S) -trans 2-amino-4 - (2-aminoethoxy) -3-butene (AVG) to inhibit ethylene synthesis. After a 14-day period, we conducted an analysis to evaluate the impact of these plant growth regulators on elongation distance, vessel occlusion percentage, and trans-nerol content. Additionally, the effects of ETH and H2O2 on endogenous plant hormones, H2O2 content, soluble protein content, and enzyme activity were investigated within 0-48 h of treatment.ResultsAfter treatment with ETH for 14 days, the extension distance of the heartwood material was 15 cm, while the trans-nerolol content was 15 times that of the ABA group. ETH and H2O2 promoted endogenous ethylene synthesis; Ethylene content peaked at 6 and 18 h. The peak ethylene content in the ETH group was 68.07%, 12.89%, and 20.87% higher than the initial value of the H2O2 group and ddH2O group, respectively, and 29.64% higher than that in the AVG group. The soluble protein content and activity of related enzymes were significantly increased following ETH treatment.DiscussionETH exhibited the most impact on heartwood formation while not hindering tree growth. This treatment effectively triggered the production of endogenous ethylene in plants and enhanced the activity of essential enzymes involved in heartwood formation. These findings serve as a valuable reference for future investigations into heartwood formation.
Qualitative study on domestic social robot adoption and associated security concerns among older adults in Slovenia
Authors: Žvanut Boštjan , Mihelič Anže 
Published: January 2024

IntroductionDespite the increasing use of domestic social robots by older adults, there remains a significant knowledge gap regarding attitudes, concerns, and potential adoption behavior in this population. This study aims to categorize older adults into distinct technology adoption groups based on their attitudes toward domestic social robots and their behavior in using the existing technology.MethodsAn exploratory qualitative research design was used, involving semi-structured interviews with 24 retired Slovenian older adults aged 65 years or older, conducted between 26 June and 14 September 2023.ResultsFour distinct groups of older adults were identified: (1) Cautious Optimists, (2) Skeptical Traditionalists, (3) Positive Optimists, and (4) Technophiles based on eight characteristics.DiscussionThese groups can be aligned with the categories of the Diffusion of Innovation Theory. Privacy and security concerns, influenced by varying levels of familiarity with the technology, pose barriers to adoption. Perceived utility and ease of use vary considerably between groups, highlighting the importance of taking into account the different older adults. The role of social influence in the adoption process is complex, with some groups being more receptive to external opinions, while others exhibit more autonomous decision-making.
The health status, social support, and subjective well-being of older individuals: evidence from the Chinese General Social Survey
Authors: Zhang Yuchen , Sun Longyu 
Published: January 2024

ObjectivesThis study aims to investigate the impact of health status and social support on the subjective well-being of older individuals.MethodsUsing data from the China General Social Survey 2017, this research analyzed 5,187 Chinese citizens aged 60 years and older. The predicted effect of each variable on subjective well-being was evaluated through hierarchical regression analysis. The direct and indirect effects of social support and health status on subjective well-being are examined based on a structural equation model.ResultsThe mental health and social support positively impact subjective well-being. Mental health mediates the effect of physical health on subjective well-being, and social support mediates the relationship between physical and mental health and subjective well-being.ConclusionThe findings provide strong evidence for the interrelationship mechanisms among the factors influencing subjective well-being. Consequently, improving mental health services and social support systems is advantageous for enhancing the well-being of Chinese seniors.
Differences between 48 and 72-hour intervals on match load and subsequent recovery: a report from the Brazilian under-20 national football team
Authors: Wilke Carolina Franco , Coimbra Cândido Celso , Drummond Filipe R. , Drummond Lucas Rios , Campos Helton Oliveira , Kanope Tane , Ramos Guilherme Passos 
Published: January 2024

PurposeTo compare the external and internal load and subsequent recovery of football players after international tournament matches separated by 48 h vs. 72 h.MethodsA total of 14 male football players from the Brazilian National Team, competing in the 2019 South American Under-20 Championship, participated in the study. Match load was quantified using GPS variables and perceived exertion ratings (1). Additionally, before and 13–15 h after each match, players answered questions about the number of hours and quality of sleep, recovery status, and muscle soreness (0–10) and provided a blood sample for creatine kinase and reactive C-protein analysis. Values of all variables were compared between matches played with 48-h intervals (matches 1–4) and 72-h intervals (matches 5–8).ResultsNo significant differences in performance or perceptual parameters were observed between matches (p = 0.136–0.953). However, CK was higher in matches 1–4 compared to matches 5 and 6; and ΔPCR was higher in matches 2 and 3 compared to matches 5 and 6, and in match 4 compared to matches 5 and 8.ConclusionsAfter matches with a 48-h rest interval, players showed increased markers of inflammation and muscle damage compared to matches with a 72-h rest interval.
Exploring the facilitators and barriers to addressing social media’s impact on anxiety within primary care: a qualitative study
Authors: Anto Ailin , Basu Arunima , Selim Rania , Zaman Jahed , Kanapathipillai Dylan , Salam Haadi , Asif Rafey Omar , Eisingerich Andreas Benedikt 
Published: January 2024

Background
Several researchers and policymakers have acknowledged the alarming association between social media (SM) usage and anxiety symptoms in young adults. While primary care holds a crucial role in the improvement of health outcomes for those presenting with anxiety, there has been no research on GPs’ perceptions of the impact of SM on anxiety. Furthermore, there has been little discussion of SM as a risk factor in anxiety-related consultations. This study is the first to use empirical research to inform how primary care can adapt to address SM’s impact on anxiety within young adults.

Aim
To identify the facilitators and barriers within primary care to addressing SM’s impact on anxiety among young adults.

Design & setting
A qualitative study of GPs in the UK.

Method

Following an exploratory pilot interview, semi-structured interviews with GPs (
n
= 7) were transcribed and thematically analysed, following an inductive approach.

Results
The following six facilitators were identified: a framework to facilitate discussion; open GP attitudes; GP training; referral pathways; larger stakeholder influence; and young adult education of social media’s impact on anxiety. The following three barriers were identified: a lack of GP awareness of SM’s impact on anxiety; cautious GP attitudes; and increased pressure on the health service.

Conclusion
This qualitative study revealed a diversity of perceptions, and these novel findings are instructive in the adaptation of primary care services to meet the current mental health needs of young adults, as well as better assisting GPs in engaging in these conversations, especially within university practice.
Reformas curriculares en educación tecnológica: experiencias de adecuación desde la perspectiva de directivos y docentes
Authors: Silva-Cueva Johan , Niño Cueva Danés Carlos Enrique , Niño Cueva Moisés Ronal , Alanya-Beltran Joel , Calderón Pizango Milton Ricardo 
Published: January 2024

Los institutos tecnológicos son centros de formación de profesionales para el desarrollo nacional, en lo últimas décadas han sido parte de las reformas curriculares a fin de adaptarse al enfoque por competencias y mejorar la calidad educativa. La investigación tuvo por objetivo conocer las experiencias de los directivos y docentes en el proceso de adecuación e implementación del currículo específicamente en las reformas del Ministerio de Educación de Perú entre 2006 y 2020. Utilizando un enfoque cualitativo y un diseño fenomenológico hermenéutico, los hallazgos revelan que la adecuación curricular fue gradual y complejo debido a las normativas, con limitaciones temporales y escasa conexión entre instituciones educativas y empresas. Aunque el currículo actual es más organizado y consensuado gracias a la participación de los involucrados, pero persisten las practicas pedagógicas tradicionales. Se puede cerrar indicando la necesidad de fortalecer la colaboración entre la academia y la industria para mejorar la formación técnica.
Habilidades investigativas en la escuela, un reto post pandemia
Authors: Chávez Lazarte Linda América 
Published: January 2024

La presente investigación estuvo referida a un estudio de caso que buscó determinar la importancia de las habilidades investigativas en la escuela pública incluyéndolas como un reto post pandemia. Su aporte metodológico inductivo con enfoque cualitativo contribuyó con la observación y el análisis de las características de la población estudiada. Para el hallazgo de los resultados se empleó como instrumento de investigación una Guía para desarrollar el cuestionario mediante la técnica de la entrevista semiestructurada, el cual permitió procesar la información sustentada y cotejada por pares. Como conclusión se determinó que, el desarrollo de habilidades investigativas guarda absoluta relevancia en el aprendizaje escolar del por tratarse de herramientas académicas de orden superior, las mismas que aplicadas en un contexto formativo post pandémico servirán en la vida futura y productiva de cada estudiante.
High Rate of Kidney Graft Failure after Simultaneous Heart–Kidney Transplantation
Authors: Okumura Kenji , Ohira Suguru , Kai Masashi , Misawa Ryosuke , Wolfe Kevin , Sogawa Hiroshi , Veillette Gregory , Nishida Seigo , Spielvogel David , Lansman Steven , Dhand Abhay 
Published: January 2024

Key Points

Simultaneous heart–kidney transplant is associated with high rates of kidney graft failure which are worse when compared with kidney transplant alone.The major causes of kidney graft failure in simultaneous heart–kidney transplant recipients were patient death and primary nonfunction of kidney graft.

Background
The indications and outcomes of simultaneous heart–kidney transplantation (SHKT) remain suboptimally defined. Risk factors for renal graft failure after SHKT also remain poorly defined.

Methods
We analyzed the renal graft outcomes among SHKT recipients using United Network for Organ Sharing database from 2015 to 2020. To evaluate for factors associated with poor renal outcomes, we compared SHKT and kidney transplantation alone recipients using propensity score matching.

Results
Among SHKT recipients, the rate of primary nonfunction (PNF) of kidney graft was 3%, the 30-day kidney graft failure rate was 7.0%, and the 30-day post-transplant mortality rate was 4.1%. The incidence of kidney delayed graft function was 27.5%. Kidney graft failure was seen early post-SHKT with most common causes of patient death (43.9%) and PNF of kidney graft (41.5%). One- and 2-year patient survival was 89.2% and 86.5%, and 1- and 2-year freedom from kidney graft failure was 85.4% and 82.7%, respectively. In subgroup analysis of SHKT recipients, use of pretransplant mechanical cardiac support (adjusted odds ratio [aOR], 2.57; P = 0.017), higher calculated panel reactive antibody (aOR, 1.76; P = 0.016), and older donor age per 10 years (aOR, 1.94; P = 0.001) were associated with PNF. Pretransplant extracorporeal membrane oxygenation support was associated with the increased risk of 30-day recipient mortality (aOR, 5.55; P = 0.002). Increased 30-day graft failure was seen in SHKT recipients with pretransplant mechanical cardiac support (aOR, 1.77; P = 0.038) and dialysis at the time of transplant (aOR, 1.72; P = 0.044). Multivariable Cox hazard analysis demonstrated that SHKT, when compared with kidney transplantation alone, is associated with increased kidney graft failure (hazard ratio, 2.56; P < 0.001) and recipient mortality (hazard ratio, 2.65; P < 0.001).

Conclusions
SHKT is associated with high rates of kidney graft failure. Identification of risk factors of renal graft failure can help optimize recipient selection for SHKT versus kidney after heart transplantation, especially after introduction of the new safety-net policy.
Effectiveness of Combined Oral Contraceptive with Chlormadinone Acetate in the Treatment of Acne and Psychological Maladaptation
Authors: Гутикова Л.В. 
Published: January 2024

Обследовано 60 женщин в возрасте 18–45 лет, у которых на коже лица были угревые высыпания разной степени тяжести. Все женщины принимали КОК, содержащий 30 мкг этинилэстрадиола и 2 мг хлормадинона ацетата. Большинство пациенток (70%) испытывали психологическое и социальное беспокойство по поводу угревой болезни. Через 3 цикла применения препарата и врачом, и пациентками отмечены улучшение состояния кожи и исчезновение угревых высыпаний соответственно в 58,3 и 61,6% случаев, через 6 циклов выздоровление отмечено пациентками в 86,7% случаев, врачом – в 71,7%, а улучшение состояния кожи и уменьшение количества акне отметили 11,6% пациенток, врач зафиксировал улучшение у 15%. Отсутствие эффекта было выявлено врачом только в 3,3% случаев. У 15% пациенток через 3 месяца и 18,3% через 6 отмечено повышение либидо. Большинство пациенток были полностью удовлетворены контрацептивным препаратом: 78,3% – через 3 цикла приема препарата и 90% – через 6. Улучшение эмоционального состояния отмечали 33,3% женщин через 3 цикла и 48,34% – через 6. Комбинированный оральный контрацептив, содержащий в своем составе этинилэстрадиол и хлормадинона ацетат, эффективно улучшает состояние кожи у пациенток с акне, обладает хорошей переносимостью, повышает либидо, обладает позитивным эффектом на психологическую, эмоциональную и социальную адаптацию женщин, что дает возможность рекомендовать этот препарат для широкого использования в повседневной клинической практике.
60 women aged 18–45 years were examined, who had acne rashes of varying severity on the skin of the face. All women took a COC containing 30 mcg of ethinyl estradiol and 2 mg of chlormadinone acetate. The majority of patients (70%) experienced psychological and social anxiety about acne. After 3 cycles of using the drug, both the doctor and the patients noted an improvement in the condition of the skin and the disappearance of acne, respectively, in 58.3 and 61.6% of cases, after 6 cycles, recovery was noted by the patients in 86.7% of cases, by the doctor – in 71.7%, and improvement in the condition of the skin and a decrease in the number of acne was noted by 11.6% of patients, the doctor recorded an improvement in 15%. The lack of effect was detected by the doctor only in 3.3% of cases. In 15% of patients after 3 months and 18.3% after 6, an increase in libido was noted. The majority of patients were completely satisfied with the contraceptive drug: 78.3% – after 3 cycles of taking the drug and 90% – after 6. Improvement of the emotional state was noted by 33.3% of women after 3 cycles and 48.34% – after 6. A combined oral contraceptive containing ethinylestradiol and chlormadinone acetate, effectively improves the skin condition in patients with acne, has good tolerance, increases libido, has a positive effect on the psychological, emotional and social adaptation of women, which makes it possible to recommend this drug for widespread use in everyday clinical practice.