bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer
Authors: Nelson Stephanie E , Gould Michael N , Hampton John M , Trentham-Dietz Amy 
Published: March 2005

Abstract
Background
Overexpression of the HER2 proto-oncogene in human cancer cells has been associated with a poor prognosis, and survival improves with therapy targeting the HER2 gene. Animal studies and protein modeling suggest that the Ile655Val polymorphism located in the transmembrane domain of the HER2 protein might influence breast cancer development by altering the efficiency of homodimerization.

Methods
To investigate this genetic polymorphism, incident cases of invasive breast cancer (N = 1,094) and population controls of a similar age (N = 976) were interviewed during 2001 to 2003 regarding their risk factors for breast cancer. By using DNA collected from buccal samples mailed by the participants, the HER2 Ile655Val polymorphism was evaluated with the Applied Biosystems allelic discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated by logistic regression adjusted for numerous breast cancer risk factors. Analysis was restricted to women with self-reported European descent.

Results
Prevalence of the Val/Val genotype was 5.6% in cases and 7.1% in controls. In comparison with the Ile/Ile genotype, the Ile/Val genotype was not significantly associated with breast cancer risk (OR 0.97, 95% CI 0.79 to 1.18), whereas the Val/Val genotype was associated with a reduced risk (OR 0.63, 95% CI 0.42 to 0.92). This inverse association seemed strongest in older women (OR 0.51, 95% CI 0.29 to 0.89 for women aged more than 55 years), women without a family history of breast cancer (OR 0.54, 95% CI 0.35 to 0.84), postmenopausal women with greater body mass index (OR 0.43, 95% CI 0.20 to 0.91 for a body mass index of 25.3 kg/m2 or more), and cases diagnosed with non-localized breast cancer (OR 0.49, 95% CI 0.26 to 0.90).

Conclusion
Although results from our population-based case-control study show an inverse association between the HER2 Ile655Val polymorphism and risk of invasive breast cancer, most other studies of this single-nucleotide polymorphism suggest an overall null association. Any further study of this polymorphism should involve sample populations with complete risk factor information and sufficient power to evaluate gene-environment interactions between the HER2 polymorphism and factors such as age and family history of breast cancer.
Achieving competitive advantage through implementing a replicable management standard: Installing and using ISO 9000
Authors: Naveh Eitan , Marcus Alfred 
Published: March 2005

AbstractThis paper investigates the effects of implementing the international standard ISO 9000 on measures of business and operating performance. Based on the literature and a case study we identified two stages in implementing ISO 9000—(1)Installation, which has two dimensions: (a) external coordination and (b) integration; and (2)Usage, which also has two dimensions: (a) in daily practice and (b) as a catalyst for change. The hypotheses were that installation of ISO 9000 is positively related to use of ISO 9000, and use of ISO 9000 is positively related to operating performance. In addition, use of ISO 9000 is positively related to business performance since operating performance is positively related to business performance. We used hierarchical linear models (HLM) to test our hypotheses and validated the results by comparing the longitudinal performance of ISO 9000 certified companies with four matched samples of companies that were not ISO 9000 certified. Our analysis indicated that while the installation stage was necessary to successfully implement ISO 9000, organizations achieved a distinct operating advantage from this replicable standard when they used it in daily practice and as a catalyst for change. These findings were based on responses to a survey of 1150 quality managers in 924 organizations, which was supplemented for about one‐third of the organizations with longitudinal information from the Compustat database on the organizations’ business and operating performance. The validation indicated that implementing the ISO 9000 standard led to improved operating performance, but that this outcome did not necessarily or automatically yield better business performance.
Converting Women
Authors: Kent Eliza F. 
Published: March 2005

Abstract
This book explores the conversion of Indians to Protestant Christianity in the 19th century. It is divided into two parts. Part I focuses on the social, religious, ideological, and historical backgrounds of south Indian, Tamil-speaking converts, and the British and American missionaries who endeavored to convert them to Christianity. Part II examines how Tamil Christian women engaged with 19th century American and European gender categories.
Emotions in Ancient and Medieval Philosophy
Authors: Knuuttila Simo 
Published: March 2005

Abstract
The first part of the book covers the theories of the emotions of Plato and Aristotle and later ancient views from Stoicism to Neoplatonism (Ch. 1) and their reception and transformation by early Christian thinkers from Clement and Origen to Gregory of Nyssa, Cassian and Augustine (Ch. 2). The basic ancient alternatives were the compositional theories of Plato and Aristotle and their followers and the Stoic judgement theory. These were associated with different conceptions of philosophical therapy. Ancient theories were employed in early Christian discussions of sin, Christian love, mystical union, and other forms of spiritual experience. The most influential theological themes were the monastic idea of supernaturally caused feelings and Augustine's analysis of the relations between the emotions and the will.
The first part of Ch. 3 deals with the twelfth‐century reception of ancient themes through monastic, theological, medical, and philosophical literature. The subject of the second part is the theory of emotions in Avicenna's faculty psychology, which, to a great extent, dominated the philosophical discussion of emotions in early thirteenth century. This approach was combined with Aristotelian ideas in later thirteenth century, particularly in Thomas Aquinas’ extensive taxonomical theory. The increasing interest in psychological voluntarism led many Franciscan authors to abandon the traditional view that emotions belong only to the lower psychosomatic level. John Duns Scotus, William Ockham and their followers argued that there are also emotions of the will. Chapter 4 is about these new issues introduced in early fourteenth‐century discussions, with some remarks on their influence on early modern thought.
CHAPTER 1 Emotions in Ancient Philosophy
Authors: Knuuttila Simo 
Published: March 2005

Abstract
The philosophical analysis of emotion was introduced by Plato and developed further by Aristotle. Plato's various ideas pertaining to feeling and emotion are dealt with in Sect. 1–3 and Aristotle's compositional theory of emotion (evaluative thought, feeling, behavioural suggestion, bodily change) in Sect, 4. The Stoic theory of emotions as judgements is discussed in Sect. 5, and the Stoic therapy aiming at freedom from the emotions (apatheia) in Sect. 6. In other later schools, the aim of the therapy was the control and moderation of emotions rather than their extirpation. Section 7 deals with the Epicurean therapy and Sect. 8 with the theories and therapeutic views of the Middle Platonists, Galen and Plotinus. The subject of the last section is the combination of ancient philosophical theories in Nemesius of Emesa's influential work On Human Nature.
CHAPTER 4 Emotions in Fourteenth‐Century Philosophy
Authors: Knuuttila Simo 
Published: March 2005

Abstract
Section 1 describes some psychological themes which were found interesting by many early fourteenth‐century thinkers, such as intuitive knowledge, self‐awareness, other reflexive acts, and voluntarism. Section 2 deals with the influential voluntarist theory of emotions in John Duns Scotus and William Ockham and their followers. As distinct from the received view, it was argued that there are also emotions of the will, such as the unpremeditated acts of complacence and dislike and non‐voluntarily felt pleasures or distresses. Adam Wodeham's discussion of the different views of emotions in Oxford in the 1320s is dealt with in Sect. 3, and some late medieval themes which influenced early modern theories in Sect. 4.
What is it not Like to be a Brain?
Authors: McGinn Colin 
Published: March 2005

Abstract
It is argued that materialism, the thesis that facts about the mind are reducible without residue to facts about the brain, fails to do justice to the nature of physical phenomena. The symmetry of identity means that if C-fibre firing is just pain, then it can have no properties that pain does not have and cannot, therefore, have any of the objective properties not possessed by pain: it cannot be observable, symmetrically accessible, conceivable from many points of view, spatial, and subject-independent. From this it follows that classic type-identity materialism is false. It does not however follow that supervenience must be rejected, or irreducibly mental properties accepted: subjective mental states might reduce to something lacking the marks of full-blown objectivity; necessary connections between pain and C-fibre firing might exist even though the two cannot be identified.
Consciousness and Cosmology: Hyperdualism Ventilated
Authors: McGinn Colin 
Published: March 2005

Abstract
This chapter takes the form of a dialogue between two world-views: a standard view, which sees consciousness evolving in a purely material universe, and an alternative, which regards the brain as a sort of interface between the world of spirit and the world of matter. The cosmological implication of the latter view is that there were originally two causally isolated universes, which were enabled to interact by the coming into existence by natural selection of the brain. This avoids the problem of emergence, the problem of explaining how consciousness could possibly emerge from matter. The advantages of this hyperdualism over standard dualism are proposed, and the objections to it that individuation in a non-spatial world is problematic and that the positing of a non-spatial world is ontologically extravagant is considered. The place of numbers and other abstracta in the non-material universe is discussed and the possibility that consciousness emerges from the abstract – abstract emergentism – is examined.
Light‐microscopy evaluation of zonular fiber morphology in dogs with glaucoma: secondary to lens displacement
Authors: Morris Rebecca A. , Dubielzig Richard R. 
Published: March 2005

AbstractLens displacement resulting in secondary glaucoma is common in terrier breeds. This study was carried out to evaluate whether light microscopy was useful in detecting abnormal patterns in zonular fiber protein. Eyes from 63 dogs with glaucoma secondary to lens displacement were evaluated for the presence of abnormal zonular fiber morphology using the following stains: hematoxylin and eosin, periodic acid Schiff (PAS), Masson's trichrome and Verhoeff's elastin stains. Two distinct forms of abnormal zonular fiber morphology were recognized and designated as zonular fiber dysplasia (ZFD) and zonular fiber collagenization (ZFC). ZFD protein morphology was characterized by being tightly adherent to the nonpigmented ciliary body epithelium, exhibiting a distinct lamellar and cross‐hatched pattern and staining strongly positive with PAS and trichrome stains, and staining negative with elastin stains. ZFD was predominant in terrier breeds (18 of 29) and Shar‐Pei dogs (4 of 29). ZFC abnormality was characterized by excessive zonular fiber that was not tightly adherent to the ciliary body epithelium and staining positive with PAS, trichrome (blue for collagen) and elastin stains. Only 7 of 19 dogs with ZFC changes were terrier breeds, and there was no pattern in the breeds affected. Fifteen of the 63 dogs used in the study had normal appearing zonular fibers. The staining pattern in these dogs matched normal controls by staining positive with PAS and Verhoeff's elastin stains and had only minimal positive staining with Masson's trichrome stain. Results suggest that light microscopy is useful in detecting breed‐related changes in zonular fiber morphology in cases of glaucoma secondary to lens displacement. These changes may correlate with the presence of abnormal zonular fiber proteins and might be important in the pathogenesis of primary lens displacement in terrier and Shar‐Pei dogs.
Optic nerve head neuroretinal rim blood flow differences in monkeys with laser‐induced glaucoma
Authors: Brooks D. E. , Kallberg M. E. , Komaromy A. M. , Ollivier F. J. , Lambrou G. N. 
Published: March 2005

AbstractIntroduction  The blood flow of the neuroretinal rim (NRR) of the optic nerve head (ONH) of the rhesus monkey with laser‐induced glaucoma was examined.Methods  Argon laser photocoagulation of the trabecular meshwork to induce elevated intraocular pressure (IOP) was performed in one eye of nine normal male rhesus monkeys. The nasal and temporal NRR of the monkey ONH were examined by the Heidelberg retina tomograph/flowmeter (HRT/HRF) under neuromuscular blockade. A mixed effect analysis of variance was used to determine significant differences between eyes and between locations in the eyes.Results  The average IOP in the hypertensive glaucoma and normal eyes was 34.8 ± 7.2 and 16.0 ± 1.9 mmHg, respectively. The HRT determined average overall cup to disc (C/D) area ratio in the glaucoma and normal eyes, which was 0.49 ± 0.28 and 0.22 ± 0.16, respectively. The mean temporal NRR HRF flow in the hypertensive eyes was significantly greater than in the normotensive eyes (P < 0.0001), than in the nasal NRR of the hypertensive eyes (P < 0.0001) and than in the nasal NRR of the normotensive eyes (P < 0.01). The mean nasal NRR HRF flow in the hypertensive eyes was significantly less than in the nasal NRR of the normotensive eyes (P < 0.01). There was no statistical difference between the mean HRF flow of the temporal and nasal NRR of the normotensive eyes. The elevated IOP positively influenced the flow values in the hypertensive eye (r = 0.724).Conclusions  The capillary microcirculation of the temporal NRR of the rhesus monkey ONH with laser‐induced glaucoma has significantly increased blood flow, and the nasal NRR significantly reduced blood flow compared to blood flow in the NRR of normal normotensive monkey eyes.
A model of coffee berry borer population growth and susceptibility to control by birds
Authors: Muccio Kaitlin R. , Crone Elizabeth E. , Reed J. Michael 
Published: February 2024

AbstractInsectivorous birds can provide ecological and economic services by decreasing pest populations in agricultural systems, but the magnitude of effect is often debated. We modeled the capacity for birds to suppress pest population growth using a common tropical coffee pest, the coffee berry borer (CBB) (Hypothenemus hampei) as a study system. Previous field experiments show that birds play a role in suppressing CBB infestations through predation, but the degree to which birds can suppress population growth enough to control infestations is unknown since CBB are only vulnerable to predators when gravid females disperse. Using previously published data on CBB life‐stage survivability, we constructed a female‐only, daily time‐step, deterministic Leslie matrix and projected CBB population growth for a single breeding season. Our goal was to assess the plausibility of CBB suppression by birds as a function of avian energy requirements, reported avian densities on coffee farms, prey composition of avian diets, estimated a caloric value of CBB, and the initial starting population size. Our model showed CBB population growth became exponential (λdaily = 1.042) and that at low, but not medium or high population sizes, were birds able to reduce population growth by 50%. In general, birds exert predation pressure on insect populations, but the ability to control infestations is complex, and is likely dependent on the initial CBB population size.
Fast Electrodeposition of MXene/PDA Composites for High‐Performance Bioelectronic Interfaces: An In Vitro Evaluation
Authors: Zeng Qi , Xing Chenyang , Xu Zhen , Liu Qing , Yang Liangtao , Yang Hui , Zhang Yi , Peng Zhengchun 
Published: February 2024

AbstractBioelectrode is critical to many biomedical researches. However, traditional materials (typically noble metals) and manufacturing techniques limit the large‐scale production of bioelectrodes. Herein, a fast electrochemical approach is proposed to deposit versatile MXene/polydopamine (PDA) composites on a metalized substrate. PDA coating can improve the adhesion between MXene and the substrate, while MXene provides rough surfaces with unique micro/nanostructure and outstanding electrical/optical/thermal performance. The impedance of the as‐prepared bioelectrode at 1 kHz is down to 8.48 Ω cm2. The corresponding cathodic charge storage capacity (CSCc) and charge injection capacity (CIC) are up to ≈250 and 6.59 mC cm−2 respectively, much superior to that of bare Pt and other conventional material‐based electrodes. The MXene/PDA composites also demonstrate robust stability under continuous electrostimulation for 1 × 108 pulse cycles and 1000 CV cycles. Moreover, MXene/PDA composites show a high and rapid photothermal response. Photoelectrochemical activity is also observed with high photocurrent, ≈40 folds larger than that of bare Pt. The utility of this new electrode in ascorbic acid sensing is demonstrated. Excellent biocompatibility is verified via neuron adhesion test and viability assay.
Activated Immune System Determines In Vivo Anti‐Tumor Effect of Phototherapy by Inhibiting Cancer‐Associated Fibroblasts
Authors: Ding Mengchao , Chen Haoyu , Guimarães Carlos F. , Reis Rui L. , Wu Lijuan , Zhang Fenglan , Lv Yaqian , Wang Tianyi , Zhou Qihui , Shi Jinsheng , Kong Xiaoying 
Published: February 2024

AbstractImmune activation has been widely recognized to promote anti‐tumor effects in vivo. However, in previous anti‐tumor studies of combined photo/immunotherapy, the tumor apoptosis pathway is widely regarded as an independent process, which led to an incomplete understanding of the anti‐tumor mechanisms of the immune system during phototherapy. Herein, the decisive role of immune activation for the anti‐tumor effect of phototherapy and its specific mechanism, are investigated by preparing a melanin@chlorin e6@hyaluronic acid and oxidized Bletilla striata polysaccharide@NO‐donor (MCH‐OBN) nanoplatform, which integrated significant immune activation by phototherapy. The comparison of anti‐tumor effects between wild‐type mice and immunodeficient mice showed that effective phototherapy provided by the MCH‐OBN can not independently kill tumor cells in vivo, as it significantly depends on the immune activation. Furthermore, the activated immune system is demonstrated to destroy the tumor cell “barrier protection” by inhibiting the growth of cancer‐associated fibroblasts (CAFs), thereby ensuring the damage of heat, reactive oxygen species (ROS), and other components of phototherapy to the tumor. Thus, this work reveals for the first time the biological consequences of immune activation that determine the anti‐tumor effect of phototherapy by regulating CAF proliferation, which is of great significance for optimizing anti‐tumor clinical treatments through phototherapy.
Humidity Stable Thermoelectric Hybrid Materials Toward a Self‐Powered Triple Sensing System
Authors: Tu Suo , Tian Ting , Xiao Tianxiao , Yao Xiangtong , Shen Sicong , Wu Yansong , Liu Yinlong , Bing Zhenshan , Huang Kai , Knoll Alois , Yin Shanshan , Liang Suzhe , Heger Julian E. , Pan Guangjiu , Schwartzkopf Matthias , Roth Stephan V. , Müller‐Buschbaum Peter 
Published: February 2024

AbstractHighly sensitive and humidity‐resistive detection of the most common physical stimuli is of primary importance for practical application in real‐time monitoring. Here, a simple yet effective strategy is reported to achieve a highly humidity‐stable hybrid composite that enables simultaneous and accurate pressure and temperature sensing in a single sensor. The improved electronic performance is due to the enhanced planarity of poly (3,‐4ethylenedioxythiophene) (PEDOT) and charge transfer between PEDOT:polystyrene sulfonate (PEDOT:PSS) and multi‐walled carbon nanotubes (CNTs) by strong π–π interaction. The preferred electronic pathway induced by a robust morphology in the hybrid composite is responsible for the high humidity stability. This study also demonstrates that the sensor has tremendous potential for intelligent object identification with a high level of 97.78% accuracy. Together with the position‐detection capability of a triboelectric nanogenerator (TENG), advantages for potential industrial applications of the triple sensing system in terms of intelligent classification without seeing are foreseen.
Wearable Microneedle Patch for Colorimetric Detection of Multiple Signature Biomarkers in vivo Toward Diabetic Diagnosis
Authors: Bao Ziting , Lu Sheng , Zhang Duo , Wang Guanyu , Cui Xiaolin , Liu Guozhen 
Published: February 2024

AbstractType 2 diabetes is rapidly emerging as a global public health problem. While blood glucose monitoring has been the primary method of managing diabetes for decades, the increasing global prevalence of the disease suggests that there might be a need to identify additional biomarkers for a more precise early diagnosis. Herein, a microneedle patch based wearable sensor is developed for the purpose of diabetic diagnosis. Utilizing methacrylic acid modified gelatin and polyvinyl alcohol in the fabrication of microneedles has improved their mechanical properties for skin penetration and increased swelling capacity for interstitial fluid extraction, thanks to the double crosslinking mechanism. The fabricated microneedles are further integrated with test paper functionalized with enzyme and dye molecules to detect multiple signature biomarkers of diabetes in vivo through a colorimetric reaction. Such a wearable microneedle patch holds significant promise for the real‐time monitoring of various biomarkers related to chronic diseases and aging.
Enhancing CAR Macrophage Efferocytosis Via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling
Authors: Chuang Skylar T. , Stein Joshua B. , Nevins Sarah , Kilic Bektas Cemile , Choi Hye Kyu , Ko Wan‐Kyu , Jang Hyunjun , Ha Jihun , Lee Ki‐Bum 
Published: February 2024

AbstractThe removal of dying cells, or efferocytosis, is an indispensable part of resolving inflammation. However, the inflammatory microenvironment of the atherosclerotic plaque frequently affects the biology of both apoptotic cells and resident phagocytes, rendering efferocytosis dysfunctional. To overcome this problem, a chimeric antigen receptor (CAR) macrophage that can target and engulf phagocytosis‐resistant apoptotic cells expressing CD47 is developed. In both normal and inflammatory circumstances, CAR macrophages exhibit activity equivalent to antibody blockage. The surface of CAR macrophages is modified with reactive oxygen species (ROS)‐responsive therapeutic nanoparticles targeting the liver X receptor pathway to improve their cell effector activities. The combination of CAR and nanoparticle engineering activated lipid efflux pumps enhances cell debris clearance and reduces inflammation. It is further suggested that the undifferentiated CAR‐Ms can transmigrate within a mico‐fabricated vessel system. It is also shown that our CAR macrophage can act as a chimeric switch receptor (CSR) to withstand the immunosuppressive inflammatory environment. The developed platform has the potential to contribute to the advancement of next‐generation cardiovascular disease therapies and further studies include in vivo experiments.