bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards more reliable evaluation in pedestrian detection by rethinking “ignore regions”
Authors: Li Gang , Li Xiang , Zhang Shanshan , Yang Jian 
Published: February 2024

AbstractIt remains a challenging task to detect pedestrians in crowds and it needs more efforts to understand why the detectors fail. When we perform an error analysis based on the traditional evaluation strategy, we find that it produces many misleading false positives, which in fact cover occluded pedestrians. The reason for this is that we usually have two kinds of annotations in the dataset: regular pedestrians (detection targets) labeled by full-body boxes and ignored pedestrians (NOT detection targets) labeled by visible boxes. Ignored pedestrians are labeled as an additional category termed the “ignore region”. Nevertheless, our detectors always predict a full-body box for each pedestrian. This gap results in the following case: when a detector successfully predicts a full-body box for those ignored pedestrians, a false positive is triggered due to the low overlap between the predicted full-body box and the labeled visible box for the ignored pedestrian. This becomes even more harmful as the detector improves and becomes more capable of locating occluded pedestrians. To alleviate this issue, we devise a new pedestrian detection pipeline, which considers the additional visible box at both the detection and evaluation stages. During detection, we predict an extra visible box apart from the full-body box for every instance; during evaluation, we employ visible boxes instead of full-body boxes to match the “ignore region”. We apply the new pipeline to dozens of detection methods and validate the effectiveness of our pipeline in reducing the over-reporting of false positives and providing more reliable evaluation results.
Continuous dependence of stationary distributions on parameters for stochastic predator–prey models
Authors: Duc Toan Nguyen , Thanh Dieu Nguyen , Huu Du Nguyen , Ba Dung Le 
Published: February 2024

AbstractThis research studies the robustness of permanence and the continuous dependence of the stationary distribution on the parameters for a stochastic predator–prey model with Beddington–DeAngelis functional response. We show that if the model is extinct (resp. permanent) for a parameter, it is still extinct (resp. permanent) in a neighbourhood of this parameter. In the case of extinction, the Lyapunov exponent of predator quantity is negative and the prey quantity converges almost to the saturated situation, where the predator is absent at an exponential rate. Under the condition of permanence, the unique stationary distribution converges weakly to the degenerate measure concentrated at the unique limit cycle or at the globally asymptotic equilibrium when the diffusion term tends to 0.
Programmes to manage food selectivity in individuals with autism spectrum disorder
Authors: Breda Chiara , Santero Sara , Conti Maria Vittoria , Cena Hellas 
Published: February 2024

Abstract
Autism spectrum disorder (ASD) is a complex group of neurodevelopmental disorders characterised by impaired social communication and restricted interests/repetitive behaviours. In this regard, sensory processing difficulties and delayed oral motor skills often predispose individuals with ASD to food selectivity (FS). It is usually associated with repetitive eating patterns that can lead to multiple malnutrition conditions. The objective of this narrative review is to present an overview about the existing nutritional interventions aiming at promoting a healthy eating pattern and addressing food selectivity among individuals with ASD. Regarding the interventions targeting nutrition education, the majority of the analysed studies failed to demonstrate their effectiveness. On the other hand, many educational interventions involving taste or cooking sessions, as well as behavioural interventions for FS, demonstrated effective results. Moreover, multidisciplinary in tailoring such programmes, including psychology speech therapy and nutritional skills, is acknowledged as a key approach.
Beyond developmental psychopathology: Positive child development
Authors: Pluess Michael 
Published: February 2024

AbstractThe field of developmental psychopathology has made significant contributions to our understanding of both typical and atypical development. However, while there are established theories for developmental psychopathology with detailed criteria for pathological outcomes, there is less agreement regarding development under optimal conditions and the definition of positive outcomes. In this conceptual paper, I make the case that a better understanding of positive child development is crucial because it will not only advance our general knowledge on human development but also complement current work on developmental psychopathology. After defining positive development as the development of positive functioning in children, such as skills, strengths, competencies, and wellbeing, rather than the absence of problems, current concepts with relevance for positive development are reviewed, before highlighting gaps in our knowledge on positive development and suggestions for future research. Although several of the reviewed frameworks provide important contributions to the conceptualization of positive development, most of them focus on positive functioning in adults with limited consideration of development in the early years. More research is needed that specifically targets the development of positive outcomes from early childhood onward in order to develop a more comprehensive and holistic theory of positive child development.
Construction of a Clear‐Sky Three Dimensional Sub‐Grid Terrain Long‐Wave Radiative Effect Parameterization Scheme Under Isotropic Assumption
Authors: Gu Chunlei , Huang Anning , Li Xin , Yang Ben , Wu Yang 
Published: February 2024

AbstractRugged topography considerably regulates the surface downwelling long‐wave radiation (SDLR) flux and further affects the surface radiation and energy balances. The three dimensional sub‐grid terrain long‐wave radiative effect (3DSTLRE) is absent in most current numerical models, which usually adopt plane‐parallel schemes to simulate the SDLR flux. This study has developed a clear‐sky 3DSTLRE parameterization scheme based on the isotropic assumption of SDLR at rugged terrains and systematically evaluated its ability over the Tibetan Plateau (TP). Results show that the 3DSTLRE scheme achieves good and stable performance regardless of the horizontal resolution, time of the year, and sub‐grid terrain complexity. At different model horizontal resolutions ranging from 0.025° to 0.8°, the normalized mean absolute errors (NMAE) of the daily SDLR flux simulated by the clear‐sky 3DSTLRE scheme over most of TP are less than 0.9%, and the NMAE of the daily SDLR flux produced by the clear‐sky 3DSTLRE scheme regionally averaged over the grids with different sub‐grid terrain complexity are less than 0.25% in different months. Neglecting the 3DSTLRE in the plane‐parallel schemes may lead to clearly underestimated SDLR flux over the rugged areas, and the underestimation increases with the horizontal resolution and sub‐grid terrain complexity. At different model horizontal resolutions, the mean underestimation of the clear‐sky daily SDLR flux simulated by the plane‐parallel scheme over most of TP ranges from 5 to 20 W · m−2 with a relative underestimation of 4∼10%. The 3DSTLRE scheme can clearly reduce the biases of plane‐parallel scheme and exhibits wide application prospects in various numerical models.
Evaluating the Model Representation of Asian Summer Monsoon Upper Troposphere and Lower Stratosphere Transport and Composition Using Airborne In Situ Observations
Authors: Smith Warren P. , Pan Laura L. , Kinnison Douglas , Atlas Elliot , Honomichl Shawn , Zhang Jun , Tilmes Simone , Fernandez Rafael P. , Saiz‐Lopez Alfonso , Treadaway Victoria , Adcock Karina E. , Laube Johannes C. , von Hobe Marc , Kloss Corinna , Viciani Silvia , D’Amato Francesco , Volk C. Michael , Ravegnani Fabrizio 
Published: February 2024

AbstractChemistry Climate Models (CCMs) are essential tools for characterizing and predicting the role of atmospheric composition and chemistry in Earth's climate system. This study demonstrates the use of airborne in situ observations to diagnose the representation of chemical composition and transport by CCMs. Process‐based diagnostics using dynamical and chemical coordinates are presented which minimize the spatial and temporal sampling differences between airborne in situ measurements and CCM grid points. The chosen process is the chemical impact of the Asian summer monsoon (ASM), where deep convection serves as a rapid transport pathway for surface emissions to reach the upper troposphere and lower stratosphere (UTLS). We examine two CCM configurations for their representation of the ASM UTLS using a set of airborne observations from south Asia. The diagnostics reveal good model performance at representing tropospheric tracer distribution throughout the troposphere and lower stratosphere, and excellent representation of chemical aging in the lower stratosphere when chemical loss is dominated by photolysis. Identified model limitations include the use of zonally averaged mole fraction boundary conditions for species with sufficiently short tropospheric lifetimes, which may obscure enhanced regional emissions sources. Overall, the diagnostics underscore the skill of current‐generation models at representing pollution transport from the boundary layer to the stratosphere via the ASM mechanism, and demonstrate the strength of airborne in situ observations toward characterizing this representation.
General Local Reactive Boundary Condition for Dissolution and Precipitation Using the Lattice Boltzmann Method
Authors: Weinmiller J. , Lautenschlaeger M. P. , Kellers B. , Danner T. , Latz A. 
Published: February 2024

AbstractA general and local reactive boundary condition (RBC) for studying first‐order equilibrium reactions using the lattice Boltzmann method is presented. Its main characteristics are accurate reproduction of wall diffusion, invariance to the wall and grid orientation, and absence of nonphysical artifacts. The scheme is successfully tested for different benchmark cases considering diffusion, advection, and reactions of fluids at solid‐liquid interfaces. Unlike other comparable RBCs from the literature, the novel scheme is valid for a large range of Péclet and Damköhler numbers, and shows realistic pattern formation during precipitation. In addition, quantitative results are in good accordance with analytical solutions and values from literature. Combining the new RBC with the rest fraction method, Péclet‐Reynolds ratios of up to 1,000 can be achieved. Overall, the novel RBC accurately models first‐order reactions, is applicable for complex geometries, and allows efficiently simulating dissolution and precipitation phenomena in fluids at the pore scale.
Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway
Authors: Gu Rou , Bai Liping , Yan Fang , Zhang Se , Zhang Xianwen , Deng Ruhua , Zeng Xiansi , Sun Bo , Hu Xiaomei , Li Ye , Bai Jie 
Published: February 2024

AbstractParkinson’s disease (PD) is characterized by the formation of Lewy body in dopaminergic neurons in the substantia nigra pars compacta (SNpc). Alpha-synuclein (α-syn) is a major component of Lewy body. Autophagy eliminates damaged organelles and abnormal aggregated proteins. Thioredoxin-1 (Trx-1) is a redox regulating protein and plays roles in protecting dopaminergic neurons against neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). However, the relationship between Trx-1 and α-syn in PD is still unknown. In the present study, the movement disorder and dopaminergic neurotoxicity in MPTP-treated mice were improved by Trx-1 overexpression and were aggravated by Trx-1 knockdown in the SNpc in mice. The expression of α-syn was increased in the SNpc of MPTP-treated mice, which was inhibited by Trx-1 overexpression and was exacerbated in Trx-1 knockdown mice. Autophagosomes was increased under electron microscope after MPTP treatment, which were recovered in Trx-1 overexpressing mice and were further increased in Trx-1 knockdown in the SNpc in mice. The expressions of phosphatase and tensin homolog deleted on chromosome ten (PTEN)-induced putative kinase 1 (PINK1), Parkin, LC3 II and p62 were increased by MPTP, which were blocked in Trx-1 overexpressing mice and were further increased in Trx-1 knockdown mice. Cathepsin D was decreased by MPTP, which was restored in Trx-1 overexpressing mice and was further decreased in Trx-1 knockdown mice. The mRFP-GFP-LC3 green fluorescent dots were increased by 1-methyl-4-phenylpyridinium (MPP+) and further increased in Trx-1 siRNA transfected PC12 cells, while mRFP-GFP-LC3 red fluorescent dots were increased in Trx-1 overexpressing cells. These results indicate that Trx-1 may eliminate α-syn in PD mice through potentiating autophagy-lysosome pathway.
A severe case of cardiospondylocarpofacial syndrome with a novel MAP3K7 variant
Authors: Nyuzuki Hiromi , Ozawa Junichi , Nagasaki Keisuke , Nishio Yosuke , Ogi Tomoo , Tohyama Jun , Ikeuchi Takeshi 
Published: February 2024

Abstract
Cardiospondylocarpofacial syndrome (CSCFS) is a congenital malformation characterized by growth retardation, facial features, short toes with carpal and tarsal fusion, extensive posterior neck vertebral fusion, congenital heart disease, and deafness. Here, we report a severe case of CSCFS with a novel variant, p.Thr187Ile, in MAP3K7. Thr187 is the main phosphorylation site for TGF-beta-activated kinase 1 encoded by MAP3K7, and this variant may cause significant abnormalities in downstream signaling.
Vision-driven metasurfaces for perception enhancement
Authors: Qiu Tianshuo , An Qiang , Wang Jianqi , Wang Jiafu , Qiu Cheng-Wei , Li Shiyong , Lv Hao , Cai Ming , Wang Jianyi , Cong Lin , Qu Shaobo 
Published: February 2024

AbstractMetasurfaces have exhibited unprecedented degree of freedom in manipulating electromagnetic (EM) waves and thus provide fantastic front-end interfaces for smart systems. Here we show a framework for perception enhancement based on vision-driven metasurface. Human’s eye movements are matched with microwave radiations to extend the humans’ perception spectrum. By this means, our eyes can “sense” visual information and invisible microwave information. Several experimental demonstrations are given for specific implementations, including a physiological-signal-monitoring system, an “X-ray-glasses” system, a “glimpse-and-forget” tracking system and a speech reception system for deaf people. Both the simulation and experiment results verify evident advantages in perception enhancement effects and improving information acquisition efficiency. This framework can be readily integrated into healthcare systems to monitor physiological signals and to offer assistance for people with disabilities. This work provides an alternative framework for perception enhancement and may find wide applications in healthcare, wearable devices, search-and-rescue and others.
Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections
Authors: Huang Yanli , Wan Xufeng , Su Qiang , Zhao Chunlin , Cao Jian , Yue Yan , Li Shuoyuan , Chen Xiaoting , Yin Jie , Deng Yi , Zhang Xianzeng , Wu Tianmin , Zhou Zongke , Wang Duan 
Published: February 2024

AbstractImplant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose a multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis to amplify the efficacy of sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine and copper, the ultrasound-activated piezo-hot carriers transfer easily to copper by polydopamine. It boosts reactive oxygen species production by piezoelectrics, and facilitates the interconversion between Cu2+ and Cu+ to promote hydroxyl radical generation via Cu+ -catalyzed chemodynamic reactions. Finally, the elevated reactive oxygen species cause bacterial membrane structure loosening and DNA damage. Transcriptomics and metabolomics analysis reveal that intracellular copper overload restricts the tricarboxylic acid cycle, promoting bacterial cuproptosis-like death. Therefore, the polyetherketoneketone scaffold engineered with the designed nanoreactor shows excellent antibacterial performance with ultrasound stimulation and promotes angiogenesis and osteogenesis on-demand in vivo.
Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy
Authors: Meng Xiangqin , Fan Huizhen , Chen Lei , He Jiuyang , Hong Chaoyi , Xie Jiaying , Hou Yinyin , Wang Kaidi , Gao Xingfa , Gao Lizeng , Yan Xiyun , Fan Kelong 
Published: February 2024

AbstractDeveloping strategies that emulate the killing mechanism of neutrophils, which involves the enzymatic cascade of superoxide dismutase (SOD) and myeloperoxidase (MPO), shows potential as a viable approach for cancer therapy. Nonetheless, utilizing natural enzymes as therapeutics is hindered by various challenges. While nanozymes have emerged for cancer treatment, developing SOD-MPO cascade in one nanozyme remains a challenge. Here, we develop nanozymes possessing both SOD- and MPO-like activities through alloying Au and Pd, which exhibits the highest cascade activity when the ratio of Au and Pd is 1:3, attributing to the high d-band center and adsorption energy for superoxide anions, as determined through theoretical calculations. The Au1Pd3 alloy nanozymes exhibit excellent tumor therapeutic performance and safety in female tumor-bearing mice, with safety attributed to their tumor-specific killing ability and renal clearance ability caused by ultrasmall size. Together, this work develops ultrasmall AuPd alloy nanozymes that mimic neutrophil enzymatic cascades for catalytic treatment of tumors.
Machine vision-based detections of transparent chemical vessels toward the safe automation of material synthesis
Authors: Tiong Leslie Ching Ow , Yoo Hyuk Jun , Kim Nayeon , Kim Chansoo , Lee Kwan-Young , Han Sang Soo , Kim Donghun 
Published: February 2024

AbstractAlthough robot-based automation in chemistry laboratories can accelerate the material development process, surveillance-free environments may lead to dangerous accidents primarily due to machine control errors. Object detection techniques can play vital roles in addressing these safety issues; however, existing detection models still suffer from insufficient accuracy in environments involving complex and noisy scenes. With the aim of improving safety in a surveillance-free laboratory, we report a deep learning (DL)-based object detector, namely, DenseSSD. For the foremost and frequent problem of detecting positions of transparent chemical vessels, DenseSSD achieved a mean average precision (mAP) over 95% based on a complex dataset involving both empty and solution-filled vials, greatly exceeding those of conventional detectors; such high precision is critical to minimizing failure-induced accidents. Additionally, DenseSSD was observed to be generalizable to other laboratory environments, maintaining its high precisions under the variations of solution colors, camera view angles, background scenes, experiment hardware and type of chemical vessels. Such robustness of DenseSSD supports that it can universally be implemented in diverse laboratory settings. This study conclusively demonstrates the significant utility of DenseSSD in enhancing safety within automated material synthesis environments. Furthermore, the exceptional detection accuracy of DenseSSD opens up possibilities for its application in various other fields and scenarios where precise object detection is paramount.
A call for increased inclusivity and global representation in pharmacogenetic testing
Authors: Kennedy April , Ma Gabriel , Manshaei Roozbeh , Jobling Rebekah K. , Kim Raymond H. , Lewis Tamorah , Cohn Iris 
Published: February 2024

AbstractCommercial pharmacogenetic testing panels capture a fraction of the genetic variation underlying medication metabolism and predisposition to adverse reactions. In this study we compared variation in six pharmacogenes detected by whole genome sequencing (WGS) to a targeted commercial panel in a cohort of 308 individuals with family history of pediatric heart disease. In 1% of the cohort, WGS identified rare variants that altered the interpretation of metabolizer status and would thus prevent potential errors in gene-based dosing.
Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins
Authors: Ozcan Selahattin Can , Kalkan Batuhan Mert , Cicek Enes , Canbaz Ata Alpay , Acilan Ceyda 
Published: February 2024

AbstractCentrosome amplification is a hallmark of cancer and PLK4 is one of the responsible factors for cancer associated centrosome amplification. Increased PLK4 levels was also shown to contribute to generation of cells with centriole amplification in mammalian tissues as olfactory neuron progenitor cells. PLK4 overexpression generates centriole rosette (CR) structures which harbor more than two centrioles each. Long term PLK4 overexpression results with centrosome amplification, but the maturation of amplified centrioles in CRs and linking of PLK4 induced amplified centrosomes has not yet been investigated in detail. Here, we show evidence for generation of large clustered centrosomes which have more than 2 centriole rosettes and define these structures as centriole rosette clusters (CRCs) in cells that have high PLK4 levels for 2 consecutive cell cycles. In addition, we show that PLK4 induced CRs follow normal centrosomal maturation processes and generate CRC structures that are inter-connected with canonical centrosomal linker proteins as C-Nap1, Rootletin and Cep68 in the second cell cycle after PLK4 induction. Increased PLK4 levels in cells with C-Nap1 and Rootletin knock-out resulted with distanced CRs and CRCs in interphase, while Nek2 knock-out inhibited separation of CRCs in prometaphase, providing functional evidence for the binding of CRC structures with centrosomal linker proteins. Taken together, these results suggest a cell cycle dependent model for PLK4 induced centrosome amplification which occurs in 2 consecutive cell cycles: (i) CR state in the first cell cycle, and (ii) CRC state in the second cell cycle.
Analysis of residential satisfaction in the conversion of Beijing’s stock buildings into rental housing
Authors: Hu Xuefen , Suo Jian , Kou Ningbo , Wu Mengxue , Wang Shiyu 
Published: February 2024

AbstractThis paper investigates the residential satisfaction levels of tenants living in rental housing converted from non-residential stock buildings in Beijing. A stratified random sampling method was used to select 353 tenants from five apartments based on the plan form and location of the units for a structured questionnaire survey. The results of a hierarchical regression analysis indicated that subjective attributes were more influential in determining residential satisfaction than the objective physical and demographic attributes of the apartments. Within the five dimensions of subjective attributes, the "interior space" dimension had the greatest impact on predicting residential satisfaction. In addition, a one-way ANOVA analysis showed that the floor plan of the apartments also played a significant role in determining residential satisfaction, S-type and office park-type (Converted from an office park) layouts received the highest satisfaction ratings. This research provides valuable insights for revitalizing non-residential stock buildings and offers theoretical support for converting more non-residential stock buildings into rental housing in the future.