bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volume‐Confined Fabrication of Large‐Scale Single‐Crystalline Molecular Ferroelectric Thin Films and Their Applications in 2D Materials
Authors: Cao Xiao‐Xing , Zhou Ru‐Jie , Xiong Yu‐An , Du Guo‐Wei , Feng Zi‐Jie , Pan Qiang , Chen Yin‐Zhu , Ji Hao‐Ran , Ni Zhenhua , Lu Junpeng , Hu Huihui , You Yu‐Meng 
Published: December 2023

AbstractWith outstanding advantages of chemical synthesis, structural diversity, and mechanical flexibility, molecular ferroelectrics have attracted increasing attention, demonstrating themselves as promising candidates for next‐generation wearable electronics and flexible devices in the film form. However, it remains a challenge to grow high‐quality thin films of molecular ferroelectrics. To address the above issue, a volume‐confined method is utilized to achieve ultrasmooth single‐crystal molecular ferroelectric thin films at the sub‐centimeter scale, with the thickness controlled in the range of 100–1000 nm. More importantly, the preparation method is applicable to most molecular ferroelectrics and has no dependency on substrates, showing excellent reproducibility and universality. To demonstrate the application potential, two‐dimensional (2D) transitional metal dichalcogenide semiconductor/molecular ferroelectric heterostructures are prepared and investigated by optical spectroscopic method, proving the possibility of integrating molecular ferroelectrics with 2D layered materials. These results may unlock the potential for preparing and developing high‐performance devices based on molecular ferroelectric thin films.
Single‐Cell Atlas of Human Ovaries Reveals The Role Of The Pyroptotic Macrophage in Ovarian Aging
Authors: Zhou Chuanchuan , Guo Qi , Lin Jiayu , Wang Meng , Zeng Zhi , Li Yujie , Li Xiaolan , Xiang Yuting , Liang Qiqi , Liu Jiawen , Wu Taibao , Zeng Yanyan , He Shanyang , Wang Sanfeng , Zeng Haitao , Liang Xiaoyan 
Published: December 2023

AbstractFemale fecundity declines in a nonlinear manner with age during the reproductive years, even as ovulatory cycles continue, which reduces female fertility, disrupts metabolic homeostasis, and eventually induces various chronic diseases. Despite this, the aging‐related cellular and molecular changes in human ovaries that occur during these reproductive years have not been elucidated. Here, single‐cell RNA sequencing (scRNA‐seq) of human ovaries is performed from different childbearing ages and reveals that the activation of the pyroptosis pathway increased with age, mainly in macrophages. The enrichment of pyroptotic macrophages leads to a switch from a tissue‐resident macrophage (TRM)‐involve immunoregulatory microenvironment in young ovaries to a pyroptotic monocyte‐derived macrophage (MDM)‐involved proinflammatory microenvironment in middle‐aged ovaries. This remolded ovarian immuno‐microenvironment further promotes stromal cell senescence and accelerated reproductive decline. This hypothesis is validated in a series of cell and animal experiments using GSDMD‐KO mice. In conclusion, the work expands the current understanding of the ovarian aging process by illustrating a pyroptotic macrophage‐involved immune mechanism, which has important implications for the development of novel strategies to delay senescence and promote reproductive health.
ZnSb Films on Flexible Substrates: Stability, Optical Bandgap, Electrical Properties, and Indium Doping
Authors: Elhoussieny Ibrahim G. , Rehaag Thomas J. , Bell Gavin R. 
Published: December 2023

AbstractUndoped and In‐doped ZnSb thin films are deposited on rigid glass and flexible polyimide (Kapton) by physical vapor deposition. Detailed structural and chemical characterization is performed along with measurement of electrical and optical properties. These properties are very similar for films on glass and Kapton. Flexible ZnSb films show remarkable stability of electrical and optical properties, which are unchanged after 104 cycles of linear bending with surface strain 0.18%. Only severe flexing after this treatment (torsional bending with surface strain 1.7%) causes progressive degradation of conductivity over tens to hundreds of cycles. The ZnSb optical direct gap is determined to be 0.89 ± 0.05 eV. The optical direct gap of β Zn4Sb3 was 1.07 ± 0.05 eV. Other absorption features in the films, including smaller indirect gaps, are discussed.
Expansion of Telestroke Coverage in Community Hospitals: Unifying Stroke Care and Reducing Transfer Rate
Authors: Alhajala Hisham , Hendricks‐Jones Melinda , Shawver Julie , Amllay Abdelaziz , Chen John Tuhao , Hajjar Monica , Robbins Sarah , Dwyer Trisha , Sedlak Emily , Crayne Christopher , Miller Brian , Kung Vieh , Burgess Richard , Jumaa Mouhammad , Zaidi Syed F. 
Published: December 2023

ObjectiveTelestroke (TS) service has been shown to improve stroke diagnosis timing and accuracy, facilitate treatment decisions, and decrease interfacility transfers. Expanding TS service to inpatient units at the community hospital provides an opportunity to follow up on stroke patients and optimize medical management. This study examines the outcome of expanding TS coverage from acute emergency room triage to incorporate inpatient consultation.MethodsWe studied the effect of expanding TS to inpatient consultation service at 19 regional hospitals affiliated with Promedica Stroke Network. We analyzed data pre‐ and post‐TS expansion. We reviewed changes in TS utilization, admission rate, thrombolytic therapy, patient transfer rate, and diagnosis accuracy.ResultsBetween January 2018 and June 2022, a total of 9,756 patients were evaluated in our stroke network (4,705 in pre‐ and 5,051 in the post‐TS expansion). In the post‐TS expansion period, stroke patients' admission at the spoke hospital increased from 18/month to 40/month, and for TIA from 11/month to 16/month. TS cart use increased from 12% to 35.2%. Patient transfers to hub hospital decreased by 31%. TS service expansion did not affect intravenous thrombolytic therapy rate or door‐to‐needle time. There was no difference in length of stay or readmission rate, and the patients at the spoke hospitals had a higher rate of home discharge 57.38% compared with 52.58% at hub hospital.InterpretationTelestroke service expansion to inpatient units helped decrease transfers and retain patients in their communities, increased stroke and TIA diagnosis accuracy, and did not compromise patients' hospitalization or outcome. ANN NEUROL 2024;95:576–582
Dihydrobenzothiazole coupled N‐piperazinyl acetamides as antimicrobial agents: Design, synthesis, biological evaluation and molecular docking studies
Authors: Bollikanda Rakesh K. , Nagineni Devendra , Pranathi Abburi Naga , Chirra Nagaraju , Misra Sunil , Kantevari Srinivas 
Published: December 2023

AbstractSubstituted saturated N‐heterocycles have gained momentum as effective scaffolds for the development of new drugs. In this study, we coupled partly saturated benzothiazoles with substituted piperazines and evaluated their antimicrobial activity. Following a three‐step reaction sequence from commercially available cyclic 1,3‐diones, a series of novel 2‐[4‐substituted‐1‐piperazinyl]‐N‐(7‐oxo‐4,5,6,7‐tetrahydrobenzo[d]thiazol‐2‐yl)acetamides (7a–af) were synthesised. 2‐Amino‐5,6‐dihydro‐benzo[d]thiazol‐7(4H)‐ones, obtained through the condensation of cyclohexane‐1,3‐diones with thiourea, were acetylated with chloroacetic chloride and then reacted with N‐substituted piperazines 6a–p to give the desired products 7a–af in excellent yields. All 32 new compounds were fully characterised by their 1H‐nuclear magnetic resonance (NMR), 13C‐NMR and high‐resolution mass spectrometry spectra. The synthetic compounds 7a–af were tested in vitro for their efficacy as antimicrobials against pathogenic strains of Gram‐positive and Gram‐negative bacteria, Streptococcus mutans and Salmonella typhi, respectively, as well as against fungal strains, including Candida albicans 3018 and C. albicans 4748. Ciprofloxacin and fluconazole served as the reference drugs. While compounds 7c and 7l showed inhibition against fungal strains with zones of inhibition of 11 and 1 mm, respectively, four analogues (7d, 7l, 7n, and 7r) demonstrated strong antibacterial action (zone of inhibition in the range of 10–15 mm). Three compounds (7j, 7l, and 7w) also exhibited moderate antitubercular activity (MIC: 6.25 µg/mL) against Mycobacterium tuberculosis H37Rv. Molecular docking investigations and the predicted physicochemical and ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties for the potent compounds made this scaffold useful as a pharmacologically active framework for the development of potential antimicrobial hits.
Searching for creativity: How people search to generate new ideas
Authors: Chavula Catherine , Choi Yujin , Rieh Soo Young 
Published: December 2023

AbstractCreativity is one of the critical skills for people in a variety of academic, work, and everyday life contexts. Searching for information is essential to the creative process. Despite the recent increased attention in research on information searching for creative tasks, there is still little understanding of how people search for information to generate novel and useful ideas. This study aims to address three key research questions: (1) What search processes do people engage in while completing creative tasks, (2) what creative thinking strategies are employed when searching to generate ideas, and (3) what challenges do people encounter while searching for creative tasks. The data were collected at a university in the United States using multiple methods, combining pre‐task interviews, search sessions that involved the generation of new ideas, and post‐task interviews. Drawing from the data analysis from 31 interviews and search sessions, we present a conceptual framework for information searching for creative tasks across academic and everyday search contexts. Our findings highlight exploration as a critical search activity when searching to generate ideas. The results of this study enhance our understanding of the relationship between search activities and creative thinking strategies.
Dynamic changes in ocular shape during human development and its implications for retina fovea formation
Authors: Rasys Ashley M. , Wegerski Andrew , Trainor Paul A. , Hufnagel Robert B. , Menke Douglas B. , Lauderdale James D. 
Published: December 2023

AbstractThe human fovea is known for its distinctive pit‐like appearance, which results from the displacement of retinal layers superficial to the photoreceptors cells. The photoreceptors are found at high density within the foveal region but not the surrounding retina. Efforts to elucidate the mechanisms responsible for these unique features have ruled out cell death as an explanation for pit formation and changes in cell proliferation as the cause of increased photoreceptor density. These findings have led to speculation that mechanical forces acting within and on the retina during development underly the formation of foveal architecture. Here we review eye morphogenesis and retinal remodeling in human embryonic development. Our meta‐analysis of the literature suggests that fovea formation is a protracted process involving dynamic changes in ocular shape that start early and continue throughout most of human embryonic development. From these observations, we propose a new model for fovea development.
Comparative pharmacokinetic analysis of sporoderm‐broken and sporoderm‐removed Ganoderma lucidum spore in rat by using a sensitive plasma UPLC–QqQ–MS method
Authors: Chen Dongjie , Zhang Guoliang , Yang Jihong , Yu Huanhuan , Xue Jin , Zhang Lu , Li Zhenhao 
Published: December 2023

AbstractPrevious studies have found that removing the sporoderm significantly enhanced antitumor and immunoregulatory activities of Ganoderma lucidum spore (GLS) compared with breaking the sporoderm. However, the pharmacokinetics of sporoderm‐removed GLS (RGLS) and sporoderm‐broken GLS (BGLS) remain elusive. To compare the pharmacokinetic differences between the two products, we developed a UPLC–QqQ MS method for determining nine representative triterpenoid concentrations. Chloramphenicol was used as an internal standard. The samples were separated on a reversed‐phase column using acetonitrile–0.1% formic acid and water–0.1% formic acid as mobile phases. Nine triterpenoids were analyzed using multiple reaction monitoring mode. The results showed that the area under the concentration–time curve from dosing to time t of all nine components was increased in RGLS compared with BGLS. And the time to the maximum concentration in BGLS was delayed compared with that of RGLS. These indicated that the absorption of RGLS was better than that of BGLS, and the sporoderm might hinder the absorption of the active components. These results increase our understanding of the bioavailability of BGLS and RGLS and indicate that increased bioavailability is one of the main reasons for the enhanced efficacy of RGLS.
Measurement of gravity in laboratories for fundamental physics using mobile devices: An approach from the Internet of Things
Authors: Muñoz‐Hernandez Tatiana , Maria Metaute Ana , Lopera Sepulveda Alex Arbey , Perez‐Taborda Jaime Andres , Montoya Cañola Alcides de Jesus , Aristizabal Ramirez Diego Luis 
Published: December 2023

AbstractIn this work, we present IoT, a freeware application for Android mobile devices that belongs to the remote laboratory platform called IoT.PhysicsSensor Mobile Edition. It incorporates the potentialities of the IoT to acquire, store, visualize, and analyze data using smartphones. This application, integrated into low‐cost hardware, can be used to conduct online and real‐time laboratory practices. Additionally, hundreds of users can be connected to the lab without limiting their participation due to the physical location or equipment available in the facilities. To test the capabilities of the architecture proposed in this work, a practice to measure the value for the acceleration of gravity from a free‐fall experience was designed. A group of 101 students from the Universidad Nacional de Colombia‐Sede Medellin and another of 63 students from Universidad Nacional de Colombia‐Sede de La Paz, Cesar, participated in the practice, thus obtaining results with a high degree of accuracy and precision and excellent reproducibility. This platform is emerging as a critical tool to face the digital transformation of educational environments, including those generated by the COVID‐19 pandemic.
Novel immunotherapeutic options for BCG‐unresponsive high‐risk non‐muscle‐invasive bladder cancer
Authors: Hannouneh Zein Alabdin , Hijazi Amjad , Alsaleem Alaa Aldeen , Hami Siwan , Kheyrbek Nina , Tanous Fadi , Khaddour Karam , Abbas Abdulfattah , Alshehabi Zuheir 
Published: December 2023

AbstractBackgroundHigh‐risk non‐muscle‐invasive bladder cancer (HR‐NMIBC) presents a challenge to many physicians due to its ability to resist Bacillus Calmette–Guérin (BCG) intravesical therapy and the substantial rate of progression into muscle‐invasive bladder cancer (MIBC). Patients who are BCG‐unresponsive have worse prognosis and thus require further management including radical cystectomy (RC), which significantly impacts quality of life. Moreover, the ongoing worldwide shortage of BCG warrants the need for policies that prioritize drug use and utilize alternative treatment strategies. Hence, there is a significant unmet need for bladder preserving therapy in this subset of patients.MethodsTo address this issue, we searched the relevant literature in PUBMED for articles published from 2019 through May of 2023 using appropriate keywords. All clinical trials of patients with HR‐NMIBC treated with immune‐related agents were retrieved from clinicaltrials.gov.Findings and Future PerspectivesExploratory treatments for BCG‐Unresponsive HR‐NMIBC included immune checkpoint inhibitors (ICI), oncolytic viral therapy, cytokine agonists, and other immunomodulators targeting TLR, EpCaM, FGFR, MetAP2, and IDO1. Some combination therapies have been found to work synergistically and are preferred therapeutically over monotherapy. Three drugs—pembrolizumab, valrubicin, and most recently, nadofaragene firadenovec‐vncg—have been FDA approved for the treatment of BCG‐unresponsive NMIBC in patients who are ineligible for or decline RC. However, all explored treatment options tend to postpone RC rather than provide long‐term disease control. Additional combination strategies need to be studied to enhance the effects of immunotherapy. Despite the challenges faced in finding effective therapies, many potential treatments are currently under investigation. Addressing the landscape of biomarkers, mechanisms of progression, BCG resistance, and trial design challenges in HR‐NMIBC is essential for the discovery of new targets and the development of effective treatments.
Balloon‐expandable transcatheter heart valves for treatment of aortic valve stenosis in patients with large aortic annuli: Evaluation of deployment balloon overfilling strategies
Authors: Schneeberger Yvonne , Sarwari Harun , Köll Benedikt , Demal Till J. , Bhadra Oliver D. , von der Heide Ina , Hannen Laura , Grundmann David , Voigtländer Lisa , Waldschmidt Lara , Schirmer Johannes , Pecha Simon , Schofer Niklas , Sörensen Nils , Blankenberg Stefan , Reichenspurner Hermann , Conradi Lenard , Seiffert Moritz , Schaefer Andreas 
Published: December 2023

AbstractObjectivesTranscatheter aortic valve implantation (TAVI) using balloon‐expandable (BE) transcatheter heart valves (THV) in aortic annuli above 29 mm includes particular procedural steps, mainly involving overfilling of the deployment balloon. Data on overfilling strategies in clinical daily practice is scarce. We herein aimed for a retrospective description of utilized overfilling strategies in those patients.MethodsBetween January 2016 and December 2022, 45 patients (100% male, 76.9 ± 6.1 years) received TAVI in aortic annuli above 29 mm using a BE THV. Overfilling volumina of the deployment balloon were left to operators' discretion. Clinical and multislice computed tomography data were retrospectively collected. Clinical endpoints were adjudicated in accordance with the updated standardized VARC‐3 definitions.ResultsProfound overfilling (+4/5 mL) was used in patients with a mild calcium burden (˂750 mm³) even in aortic annuli of 29.0–30.0 mm. Nominal/slight overfilling (+1 mL) was used in aortic annuli up to 32.5 mm but an intermediate to severe calcific burden (>750–3200 mm³). Accordingly, a low calcification group (˂750 mm³, n = 17) compared to a significant calcification group (≥750 mm³, n = 28), presented with higher overfilling volumina (2.1 ± 1.4 vs. 0.8 ± 1.0; p ˂ 0.001), although aortic annulus diameter was not different (29.8 ± 0.8 vs. 29.9 ± 0.9 mm; p = 0.7). All‐cause 30‐day mortality was 0%. Device success was 97.8%. Transvalvular mean pressure gradient at discharge was 9.5 ± 3.6 mmHg. No case of PVL >mild was documented.ConclusionExtent of overfilling of the deployment balloon largely depends on calcification burden in addition to aortic annulus diameter with significant and profound overfilling particularly in patients with a calcification burden of the aortic valve complex ˂750 mm³.
The international HTA database returned incomplete search results for NICE technology appraisals: An exploratory study and discussion of the implications
Authors: Cooper Christopher , Smith Sabrina 
Published: December 2023

AbstractIntroductionThe International Network of Agencies for Health Technology Assessment (INAHTA) database offers a single point of access for identifying technology appraisals, in contrast to searching multiple websites directly. The aim of this research is to compare the coverage of the INAHTA and Centre for Reviews and Dissemination (CRD) Health Technology Assessment (HTA) databases with direct searching on the National Institute for Health and Care Excellence (NICE) website to identify Technology Appraisals published by NICE.MethodsNICE Technology Appraisals were downloaded from the NICE website (April 2022). Technology Appraisals were randomized and the first 20 Technology Appraisals constituted data for analysis. The INAHTA and CRD HTA databases were searched to determine if the 20 Technology Appraisals available on the NICE website were also available for retrieval.ResultsCoverage was incomplete. INAHTA: 15 of 20 Technology Appraisals (75%) were not identified via full title or intervention‐specific searches. CRD HTA: 7 of 12 Technology Appraisals (58%) that were published before the last update of the database were not identified.ConclusionFindings indicate that researchers seeking to identify NICE Technology Appraisals should search the NICE website directly. How this finding impacts identification of guidance from other agencies should be evaluated.
Synthesis and Characterization of Ionic Li+@C70 Endohedral Fullerene
Authors: Ueno Hiroshi , Kitabatake Daiki , Mabuchi Takuya , Aoyagi Shinobu , Itoh Takashi , Deng Ting , Misaizu Fuminori 
Published: December 2023

AbstractIon‐endohedral‐fullerene has attracted growing interest due to the unique electronic and structural characteristics arising from its distinctive ionic nature. Although there has been only one reported ion‐encapsulated fullerene, Li+@C60, a significant number of fundamental and applied studies have been conducted, making a substantial impact not only in chemistry and physics but also across various interdisciplinary research fields. Nevertheless, studies on ion‐endohedral fullerenes are still in their infancy due to the limitations in variety, and hence, it remains an open question how the size and symmetry of fullerene, as well as the motion and position of the encapsulated ion, affect their physical/chemical properties. Herein, we report the synthesis of lithium‐ion‐endohedral [70]fullerene (Li+@C70 X−, X=PF6− and TFSI−), a novel ionic endohedral fullerene. X‐ray crystallography confirmed the encapsulation of Li+ by C70 cage as well as its ion‐pair structure stabilized by external TFSI− counter anion. The encapsulated Li+ drastically lowered the orbital energy of the C70 cage by Coulomb interactions but did not affect the orbital energy gap and degeneracy. DFT studies were also performed, which supported the experimentally observed electronic effects caused by the encapsulated Li+.
The spillover effects of positive and negative corporate social responsibility publicity: How and why the effect is lessened versus amplified
Authors: Jung Sojin , Shin Daeun Chloe , Woo Hongjoo , Jin Byoungho Ellie 
Published: December 2023

AbstractBuilt on the categorization theory and Herzberg's dual‐factor theory, this study consisted of two experiments to investigate how and when small brands were affected by the corporate social responsibility (CSR) performance of other brands in the same product category. This study specifically focused on the type of CSR publicity (positive vs. negative), brand fit (high vs. low), and other brands' leadership positions (high vs. low). The results of Study 1 (156 U.S. consumers) revealed that a leading brand's CSR activities can increase consumers' CSR expectations toward another big brand more than that toward a small brand, by setting up consumers' CSR expectation standards toward the industry as a whole. That is, the big brand's CSR performance was less likely to increase CSR expectations toward the small brand. Study 2 (244 U.S. consumers) confirmed that a brand's CSR activities positively influence its product attitude. In addition, the effect of a small brand's negative CSR publicity on its product attitude was mitigated by other brands' similar publicity. In contrast, other brands' publicity did not amplify the effect of a small brand's positive CSR publicity. These findings manifested small brands were conditionally influenced by other brands in the same category. This suggested that small brands should strategically allocate resources to fulfill CSR by determining their position relative to leading brands as well as to other players in the market.