bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare combination of alloantibodies causing hemolytic disease of the newborn – Challenge for identification
Authors: Shah Rakeshkumar , Anvarsha Ajeemsha 
Published: February 2024

Abstract
Hemolytic disease of the newborn (HDN) refers to the destruction of the fetal and newborn red cells by maternal red cell antibodies specific for paternally inherited antigens on fetal red cells or erythroid precursors.[1] ABO-incompatibility is the most common cause of HDN. Rh-negative mothers can be alloimmunized with Rh-positive fetus. Prophylactic Rh immunoglobulin use has greatly reduced the HDN due to Rh incompatibility. Alloimmunization can also occur due to other clinically significant minor blood group antigens such as E, c, C, k, KP(a), Js(a), Js(b), Jk(a), Jk(b), Fy(a), Fy(b), S, s, and U. Multiple alloantibodies in mothers’ blood can pose a difficult challenge for identification and finding compatible blood for exchange transfusion. We report a case of HDN due to multiple antibodies and a rare combination of anti-c and anti-Jkb, challenges associated with the identification, confirmation, and finding of compatible blood units.
Identification of antibody specificity using adsorption-elution studies with incompatible packed red cell unit
Authors: Nivedita Kella , Mukherjee Somnath , Mishra Debasish , Datta Namrata , Sahu Ansuman , Prakash Satya 
Published: February 2024

Abstract
Antibody identification is usually performed by antibody identification panels which are specially selected red cells, at least one of which has a homozygous expression for all clinically significant blood group antigens facilitating agglutination upon reaction with specific antibodies even exhibiting dosage. In general, adsorption elution is used in determining antibody specificities in the background of multiple alloantibodies with or without autoantibodies. Herein, we present a classic case where a routine antibody identification panel failed to detect a solo antibody from patient serum, following which we tested the eluate obtained after adsorption with a cross-match incompatible packed red blood cell unit using the same antibody identification panel, which unveiled the Fyb antibody.
A study to assess the levels of free protein S in pregnant and nonpregnant women in a tertiary care center in Western Maharashtra
Authors: Kushwaha Neerja , Biswas Amit Kumar , Baranwal Ajay Kumar , Roy Bidhan , Pawar Amit Ajay , Dimri Ujjwal , Bhowmik Sujay 
Published: February 2024

Abstract:

BACKGROUND:
Pregnancy is a hypercoagulable state increasing the risk of thrombosis and maternal mortality. Free protein S (FPS) levels are significantly reduced during pregnancy as compared to nonpregnant women. This study aims to ascertain the mean FPS levels for Indian pregnant women and study various factors like age, parity, trimester, hemoglobin (Hb) in relation to FPS.

MATERIALS AND METHODS:
521 pregnant and equal number of nonpregnant women were included in the study. Blood samples were collected and evaluated for FPS and Hb levels. P < 0.05 was considered statically significant.

RESULTS:
Mean FPS levels in pregnant women were significantly lower than nonpregnant women and showed a statistically significant fall in all the three trimesters. Mean Hb levels were also lower in pregnant females however correlation between FPS levels and Hb, age, and parity were not found to be significant.

CONCLUSION:
This study found that the mean FPS levels in healthy pregnant females decrease with increasing gestational age. The mean FPS levels will be useful in the Indian scenario as our study found FPS levels to be much lower than other studies.
Analysis of risk factors for red blood cell alloimmunization and its incidence in hemoglobinopathy patients at a tertiary care center in Odisha, Eastern India
Authors: Mukherjee Somnath , Mishra Debasish , Sahu Ansuman , Datta Namrata , Das Niladri , Prakash Satya 
Published: February 2024

Abstract

BACKGROUND:
Sickle cell disease (SCD) and thalassemia are common hemoglobinopathies in Eastern India. Regular blood transfusion in these patients leads to alloimmunization. Finding compatible red blood cell units remain a challenge in these patients delaying the transfusion support.

AIMS:
This study aims to estimate the frequency of alloimmunization and predicts the associated risk factors.

METHODOLOGY:
A retrospective study was conducted for 2 years. Data were retrieved from the immunohematology work-up record. The Chi-square statistics determined the risk factors associated with alloimmunization. Multivariate regression analysis was used to identify independent risk factors of alloimmunization, adjusting the confounders. A P < 0.05 was considered as statistically significant.

RESULTS:
Forty-seven patients out of 132 developed antibodies. Of these, 41 presented with only alloantibodies, three patients had only autoantibodies, and the rest 3 had both autoantibodies and alloantibodies. Most commonly observed alloantibodies were against Rh, Kidd, Duffy, and S antigens. SCD appeared a significant risk factor for the development of alloimmunization in the Chi-square test (P = 0.003). However, multivariate analysis revealed only age of more than 2 years at the first transfusion, and up to ten transfusions are independent risk factors of alloimmunization (P < 0.05).

CONCLUSION:
We found a high incidence of alloimmunization in multitransfused hemoglobinopathies patients in this region. This study also shows the first transfusion at an age of more than 2 years and up to 10 transfusions are independent predictors of alloimmunization.
Adsorption and elution study detected misidentification of para-Bombay phenotype donor in an incompatible crossmatch with Bombay phenotype patient
Authors: Nivedita Kella , Mukherjee Somnath , Prakash Satya , Sahu Ansuman , Mishra Debasish 
Published: February 2024

Abstract
Bombay and para-Bombay are rare phenotypes with H antigen-deficient red blood cells. A 54-year-old male patient suffering from suspected malignant pleural effusion was planned for thoracotomy. The patient’s blood group showed blood group discrepancy during pretransfusion testing due to ABO isoagglutinin. Further workup with anti-H lectin was negative with pan-reactive antibody screening and negative autocontrol, which suggested that the patient is Bombay RhD positive. A known Bombay phenotype donor was called for donation. That Bombay donor is a para-Bombay donor incorrectly labeled as Bombay in another hospital. During pretransfusion testing, there was an incompatible crossmatch. Hence, the adsorption of donor red cells with the patient’s serum was performed, followed by heat elution. The eluate was pan-reactive with an antibody screening panel indicating anti-H present. The Lewis phenotype of the donor is Leb positive, which reflects the secretor status of the individual. This case highlights the importance of reverse grouping, adsorption, Lewis phenotyping, and elution testing in detecting and differentiating Bombay and para-Bombay phenotypes to avoid fatal adverse transfusion events.
Role of rapid tests in diagnosis of bloodstream infections and their effect on promoting antibiotic stewardship among febrile neutropenic patients in Alexandria
Authors: Nassar Ingy A , Nour El-Deen Amina A , Hassan Hoda A H , Ghallab Omar M , Arafa Shams A F 
Published: February 2024

Abstract

Background
Bloodstream infections (BSIs) in neutropenic patients significantly contribute to morbidity and mortality. The rapid identification and determination of antimicrobial susceptibility of pathogens causing BSIs can help in early initiation of targeted antimicrobial therapy and allow de-escalation of unnecessary empirical antimicrobials.

Aim
This study evaluated the rapidity and accuracy of gram-stained smear from blood culture bottles and direct VITEK 2 to identify and determine antimicrobial susceptibility of pathogens causing BSIs and assessed the effect of these tests on modification of empiric therapy.

Patients and methods
Blood cultures were collected from 100 febrile neutropenic patients from the Hematology Unit in Alexandria Main University Hospital. Gram-stained smears were prepared from blood culture bottles; blood from bottles with suggestive smears was directly inoculated into the VITEK 2 system, and results were compared with conventional methods. Results were instantly reported to clinicians. Empirical antimicrobials and their modification were recorded.

Results
BSI was detected in 30% of patients. Gram-negative bacteremia was predominant (24/30). Gram-stained smears showed complete accordance with conventional methods in 99 samples. VITEK 2 correctly identified all tested microorganisms, and the overall agreement in susceptibility testing was 100 and 95.2% for gram-positive and gram-negative bacteria, respectively. The effect of these rapid tests on empiric antimicrobial therapy was evident in 12 of 30 patients with documented BSIs (40%).

Conclusion
Gram-stained smear and direct VITEK 2 testing when integrated with instant reporting is a valid approach to guide targeted therapy in neutropenic patients in the context of extremely resistant pathogens.
Development of mobile application for cervical cancer screening in women: Protocol of a multi-phase study
Authors: Ghasemi-Gujani Marzieh , Savabi-Esfahani Mitra , Noroozi Mahnaz , Satari Mohammad 
Published: February 2024

BACKGROUND:Cervical cancer is one of the most common cancers in women. It is considered preventable due to the possibility of screening. The common barriers to cervical cancer screening include lack of knowledge, lack of time, and wrong beliefs. The use of e-Health technologies is one of the approaches for health promotion. The present study is aimed to the development of a mobile application for cervical cancer screening in women.MATERIALS AND METHOD:This is a multi-phase study. In the first step, a literature review will be conducted to examine factors related to cervical cancer screening and existing applications related to cervical cancer and its screening. Then, in the second step, a cross-sectional study will be conducted to investigate the factors related to cervical cancer screening in 246 women referred to comprehensive health centers and women’s clinics in teaching hospitals in Isfahan, Iran. The comprehensive health centers and women’s clinics in teaching hospitals will be randomly selected using a lottery method. Using convenience sampling, women who meet the inclusion criteria will be included in the study, provided they provide informed consent. The data will be collected using a questionnaire, and then the descriptive and inferential statistical tests and SPSS18 software will be used to analyze the data. In the third step, specialists (gynecologists, reproductive health specialists, and midwives) will prioritize the application content by filling out a questionnaire. Then, the research team will compile the application content draft, and this draft will be reviewed and approved by experts on the expert panel. The prototype of the application will be prepared, and experts will evaluate it in the fifth step.DISCUSSION:The results of this study will result in the development of applications for cervical cancer screening. The use of mobile applications can be useful in lifting some of the barriers to screening. Therefore, developing such applications may help improve cervical cancer screening.
Co-occurrence of Modifiable Risk Factors for Cardiovascular Disease amongst Diabetic Patients in Lagos State, Nigeria
Authors: Odukoya Oluwakemi Ololade , Isikekpei Brenda C , Nwaneri Solomon Chiekezi , Akodu Babatunde , Odeniyi Ifedayo , Oluwole Esther O , Osuntoki Akinniyi 
Published: February 2024

Abstract

Background:
Diabetes significantly increases the likelihood of developing cardiovascular disease (CVD). This risk can be reduced by addressing modifiable risk factors. The objectives of this study were to assess the modifiable risks for CVD amongst persons with diabetes and identify the factors associated with multiple risk factors.

Methods:
This cross-sectional study was conducted amongst 357 diabetic patients attending a large tertiary hospital in Southwest Nigeria. Eligible patients were recruited consecutively on clinic days till the minimum sample size was reached. An interviewer-administered survey tool adapted from the World Health Organization STEPS was used to obtain information from study participants. The following risk factors were assessed: tobacco use, obesity, high blood pressure, physical activity, sedentary time and hours of sleep. Data were analysed using the STATA version 15.0 (Stata Corp.) statistical programme.

Results:
The mean age of the participants was 61.7 ± 12.6 years, and they were mostly females (63.9%). Of the risk factors assessed, the most prevalent modifiable risk factors amongst the respondents were inadequate sleep – <8 h on average (91.6%), abdominal obesity (82.6%) and high blood pressure (72%). Others were inadequate physical activity (56%) and lifetime tobacco use (21%). Up to 40.3% of the diabetic persons had three or more co-existing CVD risk factors. Age, gender, work and marital status (P ≤ 0.01) were statistically associated with multiple CVD risk factors. Being male, unmarried and increasing age were predictors of multiple CVD risk factors amongst the diabetic patients.

Conclusion:
A significant proportion of the diabetic patients have multiple co-existing modifiable CVD risks. Abdominal obesity and poor sleep were the most prevalent. Older men who are unmarried were more likely to have multiple risks. Primary and secondary preventive measures to address CVD risks amongst diabetic patients are warranted and should target older unmarried men.
LIGHT COLOUR INFLUENCES THE MORPHOLOGICAL TRAITS OF THE Cryptocoryne elliptica Hook F., AN AQUATIC PLANT
Authors: Jamaludin Azi-Azeyanty , Ahmad Amirrudin , Ahmad Aziz 
Published: February 2024

Light is used to enhance the appearance of the fish and supports the survival of living ornamental aquatic plants in aquariums. The light required by the fresh aquatic plants is different among the species. This study examined the effects of light colours, which are white, blue, red, and green on tissue culture-derived Cryptocoryne elliptica grown under submergence conditions. The morphological traits and chlorophyll content of the planets were measured for ten weeks. Results showed that plantlets’ growth under blue light exhibited the longest petioles (4.9 ± 0.5 cm), leaf length (3.0 ± 0.2 cm), leaf width (1.3 ± 0.4 cm), and leaf number per plantlet (p < 0.05) compared to other lights. The highest chlorophyll content (0.72 mg/g fresh wt.) was recorded in the leaves of plantlets under white light. The number of newly produced shoot tips did not significantly differ among the light treatments (p > 0.05). Experimenting with different propagation methods, hormone treatments, or adjustments to light intensity or duration may provide insights into improving the production of new plantlets in future studies.
Pengembangan Sistem Pembimbingan Tugas Akhir Online pada Prodi Multimudia PSDKU Medan menggunakan Framework CodeIgniter
Authors: - Andrian , Siregar Efrizal , Agustina Ika , - Sudirman 
Published: February 2024

Teknologi berkembang sangat cepat saat ini, hal ini dipengaruhi oleh berkembangnya teknologi perangkat lunak dan perangkat keras yang dapat digunakan dalam berbagai hal. Perkembangan teknologi yang berkembang saat ini telah memasuki berbagai aspek kehidupan yang ada dimasyarakat, sehingga beberapa pola-pola kegiatan mengalami perubahan dengan memanfaatkan perkembangan teknologi di era 4.0 saat ini. Salah satu perkembangan teknologi tersebut dimanfaatkan dalam institusi pendidikan di tingkat perguruan tinggi negeri maupun swasta. Kegiatan belajar mengajar mahasiswa sedikit banyak juga mulai memanfaatkan perkembangan teknologi seperti pembelajaran secara online, pembibingan secara online dan kegiatan lain yang dilaksanakan secara online. Kegiatan-kegiatan tersebut memudahkan dosen dan mhasiswa untuk dapat melakukan kegiatan tersebut dari mana saja asalkan terkoneksi dengan internet. Namun penerapan teknologi tepat guna tersebut, masih jarang diimplementasikan kedalam proses penyusunan dan pembimbingan Tugas Akhir mahasiswa.Politeknik Negeri Media Kreatif PSDKU Medan Prodi Multimedia adalah salah satu program studi yang sedang berkembang dan menerapkan teknologi dalam kegiatan pembimbingan tugas akhir mahasiswa. Teknologi yang diterapkan adalah dengan menggunakan Software Framework Codeigneter. Selama ini proses pembimbingan tugas akhir dilakukan secara konvensional dengan menggunakan kertas sebagai media pembimbingan yang jika ada revisi akan menggunakan kertas yang baru sampai tugas akhir tersebut siap untuk di jilid. Metode penelitian pada penelitian ini adalah pengembangan aplikasi Framwork Codeigniter pada tugas akhir mahasiswa. Oleh karena itu, Prodi Multimedia Politeknik Negeri Media Kreatif dapat mengembangkan suatu website bimbingan tugas akhir mahasiswa secara online dengan menggunakan Software Frame agar dapat meminimalisir biaya dan waktu saat bimbingan. Hasil penelitin ini adalah uji coba pada mahasiswa Multimedia yang melakukan pembimbingan Tugas Akhir.
Pengaruh Islamicity Performance Index Terkait Nilai Perusahaan dengan Konsep Maqashid As-Syariah
Authors: Illah Muhamad Atho’ , Sundari Sri , Boedoyo M. Sidik , Sianipar Leo 
Published: February 2024

The Islamicity Performance Index is a performance measurement tool that is able to reveal the materialistic and spiritual values ​​that exist in sharia companies. Performance measurement using the Islamicity Performance Index is only based on information available in the annual financial reports. This index refers to Profit Sharing Ratio, Zakat Performance Ratio, Equitable Ratio, Director Employess Welfare Ratio, Islamic investment vs non-Islamic investment, Islamic income vs non-Islamic income and AAOFI index. The results of this study indicate that Islamic financial performance (Islamicity Performance Index) is able to significantly and positively influence company value as measured using the concept of Maqashid as-Syariah. So that if the Islamic financial performance (Islamicity Performance Index) in the ranking is considered UNSATISFACTORY, it will have an impact on company value in the Maqashid as-Syariah concept which also tends to get a bad rating in the eyes of investors. And vice versa, if the rating is considered SATISFACTORY, then the value of the company will tend to get a good assessment and added value in the eyes of investors. Firm size is able to negatively moderate (weaken) the relationship of the Islamicity Performance Index to firm value in Islamic Commercial Bank companies. The results that occurred in this study could also be caused by macroeconomic factors that greatly affect the performance of Islamic banking in Indonesia with an increase in inflation which has a negative impact on Islamic banking financial performance (ROA).
Keywords: Islamicity Performance Index; syariah companies; Maqashid as-Syariah
Pengaruh Kualitas Pelayanan dan Citra Destobasi terhadap Loyalitas Pengunjung Wisata Mangrove dengan Kepuasan Wisatawan sebagai Variabel Intervening
Authors: Lutfiyah Zekiyatul , AS Fathor 
Published: February 2024

This study aims to identify the effect of service quality variables and destination image on tourist loyalty through tourist satisfaction. the research approach used is quantitative causality, with the research population being all visitors to labuhan madura mangrove tourism, the sample size is 112 respondents and the sampling technique used is purposive sampling. this research was collected by distributing questionnaires and the results will be analyzed using the Partial Least Square (PLS) method. The results stated that service quality has a positive and significant effect on tourist loyalty, service quality has a positive but insignificant effect on tourist satisfaction, destination image has a positive and significant effect on tourist loyalty, destination image has a positive and significant effect on tourist satisfaction, and tourist satisfaction has a positive and significant effect on tourist loyalty.
Keywords: Service Quality, Destination Image, Satisfaction, And Loyalty.
Social Reintegration and Life Satisfaction among Uganda Migrant Worker Returnees from Middle East
Authors: Ssenjinja David , Rukanyangira Nazarious , Kiyingi Pio Frank 
Published: February 2024

Purpose: The current study was undertaken to establish the contribution of social reintegration and life satisfaction of Ugandan migrant worker returnees from Middle East. Its objectives main objective was to analyse the influence of social reintegration on life satisfaction among Uganda migrant worker returnees from Middle East.
Materials and Methods: In an effort to address the set objectives, a cross-sectional survey design which followed both quantitative and qualitative research approaches was adopted. Data was collected from a total quantitative sample of 218 Ugandan migrant worker returnees from Middle East. A qualitative sample of 25 managers of registered labour export companies and ministry officials in Uganda was determined by saturation point approach. The data was analysed at descriptive and inferential level. Quantitative and qualitative research were used because they are complementary methods that work well together to provide insights that are both deep and wide.The key references in the study are by (Nimkar, R., Savage, E., Tesfalidet, I., & Adugna, G. (2020)) who revealed that that having a safe, satisfactory and affordable place to live is critical to successful reintegration.
Findings: The study findings show a poor life satisfaction amongst the respondent Ugandan migrant worker returnees (Mean = 2.63, SD = 1.53). Such poor life satisfaction were in terms of the returnees not being self-sufficient upon returning, poor intention to return guided by achieving the migration objectives, life not being close to ideal in several ways and rarely having a safe, satisfactory and affordable place to live. The respondents also reported not satisfied with their well-being, with life conditions of poor and rarely secure a means of livelihood. The respondents equally reported rarely holding a stock of incomes alongside the savings and to date not getting the basic things needed in life. The study concluded that that sufficient evidence demonstrates a significant relationship exists between social reintegration and life satisfaction among Uganda migrant worker returnees from Middle East. These results shows that the more the social reintegration, the better the level of life satisfaction among Uganda migrant worker returnees from Middle East and vice versa.
Implications to Theory, Practice and Policy: Finally, the policy makers at the Ministry of Gender, Labour and Social developmenteed develop a well-informed local understandable framework and strategy for assessment of performance of government and external labour recruitment organisations in as far as migrant reintegration programmes are concerned for enhanced social reintegration.