bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decoding in the Fourth Dimension: Classification of Temporal Patterns and Their Generalization Across Locations
Authors: Santos‐Mayo Alejandro , Gilbert Faith , Ahumada Laura , Traiser Caitlin , Engle Hannah , Panitz Christian , Ding Mingzhou , Keil Andreas 
Published: January 2025

ABSTRACTNeuroimaging research has increasingly used decoding techniques, in which multivariate statistical methods identify patterns in neural data that allow the classification of experimental conditions or participant groups. Typically, the features used for decoding are spatial in nature, including voxel patterns and electrode locations. However, the strength of many neurophysiological recording techniques such as electroencephalography or magnetoencephalography is in their rich temporal, rather than spatial, content. The present report introduces the time‐GAL toolbox, which implements a decoding method based on time information in electrophysiological recordings. The toolbox first quantifies the decodable information contained in neural time series. This information is then used in a subsequent step, generalization across location (GAL), which characterizes the relationship between sensor locations based on their ability to cross‐decode. Two datasets are used to demonstrate the usage of the toolbox, involving (1) event‐related potentials in response to affective pictures and (2) steady‐state visual evoked potentials in response to aversively conditioned grating stimuli. In both cases, experimental conditions were successfully decoded based on the temporal features contained in the neural time series. Spatial cross‐decoding occurred in regions known to be involved in visual and affective processing. We conclude that the approach implemented in the time‐GAL toolbox holds promise for analyzing neural time series from a wide range of paradigms and measurement domains providing an assumption‐free method to quantifying differences in temporal patterns of neural information processing and whether these patterns are shared across sensor locations.
Validating the parental reflective functioning questionnaire ‐ infant version using a rasch model
Authors: Stuart Anne Christine , Egmose Ida , Wendelboe Katrine Isabella , Smith‐Nielsen Johanne , Væver Mette Skovgaard 
Published: January 2025

AbstractParental reflective functioning is the parent's ability to reflect on the psychological processes in their child and in themselves as a parent. Recently, an infant version of the Parental Reflective Functioning Questionnaire, PRFQ‐I, has been developed and validated using confirmatory factor analyses. The present study aims to validate the PRFQ‐I using a Rasch model in a sample of 531 Danish mothers at risk of depression and their infants aged 2–11 months. Our findings indicate that seven response categories were too many for the mothers to distinguish across all items. Prementalizing showed adequate psychometric properties, while Certainty of Mental States and Interest and Curiosity required recoding with 4 and 5 as the optimal scores, respectively. After rescoring, both subscales overall showed adequate psychometric properties. However, shortening Certainty of Mental States may be advisable due to local dependency between items 8 and 17. Additionally, items 2 and 14 (“I always know what my child wants” and “I always know why I do what I do to my child”) may function better as a separate subscale. We recommend that scores on both Certainty of Mental States and Interest and Curiosity should be analyzed and interpreted in a curvilinear rather than linear manner.
What we have learned from trying to remove oral phenylephrine from the market
Authors: Hatton Randy C. , Hendeles Leslie 
Published: January 2025

AbstractA 2023 United States Food and Drug Administration (FDA) Nonprescription Drug Advisory Committee unanimously voted that oral phenylephrine is not Generally Recognized As Safe and Effective (GRASE). This decision resulted, in part, from our nearly 20 years as clinical pharmacists advocating for patients with nasal congestion. As a result, the FDA recently posted a proposal to remove oral phenylephrine from the market, and the American College of Clinical Pharmacy (ACCP) has been a key stakeholder supporting the removal of oral phenylephrine from the market. ACCP members are encouraged to submit comments to the FDA regarding the market status of oral phenylephrine. In this article, we describe the role of a Freedom of Information request for unpublished data, our systematic review and meta‐analysis of the data upon which the FDA relied to approve oral phenylephrine, our two Citizen Petitions, and modern data, including an unpublished study from clinicaltrials.gov.
Calcium Phosphate‐Induced Injury in Kidney Tubular Cells—Supersaturated Solution vs Preformed Crystals
Authors: Ukaeje Onyebuchi C. , Roy Sanjit K. , Shin Samuel , Raheem Sumiyya , Reyes Cory , Bandyopadhyay Bidhan C. 
Published: January 2025

ABSTRACTCrystalline nephropathy (CN) is characterized by deposition of microcrystals within the kidney tubular microstructure, specifically in the renal tubular cells. Nephropathic conditions have been observed in kidney stone patients as nephrocalcinosis, resulting from the deposition of calcium phosphate (CaP) microcrystals mainly within the renal tubule. CaP microcrystals trigger nephrotoxicity and cell death leading to acute and chronic kidney disease and in some cases end stage renal disease. Although supersaturation of calcium (Ca2+)‐ and phosphate (PO43−) ions in the urine was described as a main factor the precise mechanism of cell death by distinguishing the impact of supersaturated solution vs the crystalline substances is unclear. Here we show the differential effect of CaP solution vs preformed crystal (as crystalline CaP) on the nephrotoxicity and the degree and type of cell death using a murine kidney tubular cell line, LLCPK1. We examined the cellular [cell viability, lactate dehydrogenase (LDH) and H2O2 releases and Annexin+ propidium iodide (PI) staining] and molecular events [gene expressions, oxidative and endoplasmic reticular (ER) stress] towards understanding the mechanism of CN. The results of the study demonstrated that CaP in solution exerts injury effect on LLCPK1 cells. The addition of CaP solution showed stronger necrosis than the preformed crystals as shown by PI staining and the releases of LDH and H2O2. Overall, the results in the study revealed a novel mechanism differentiating the kidney cell injury between the insult mediated by supersaturated CaP solution and preformed CaP crystals.
Targeted Therapies: The Role of Monoclonal Antibodies in Disease Management
Authors: Salah Akram N. , Hashem Amr H. , Zaki Mohamed Bakr , Abulsoud Ahmed I. , Atta Asmaa M. , Elkalla Wagiha S. , Moustafa Hebatallah Ahmed Mohamed , El‐Dakroury Walaa A. , El‐Tokhy Fatma Sa'eed , ElBoghdady Jasmine A. , Rizk Nehal I. , Abdel Mageed Sherif S. , Mohammed Osama A. , Abdel‐Reheim Mustafa Ahmed , Alghamdi Huda O. , Doghish Ahmed S. 
Published: January 2025

ABSTRACTMonoclonal antibodies (mAbs) are a key class of biotherapeutic medicines used to treat a wide range of diseases, such as cancer, infectious diseases, autoimmune disorders, cardiovascular diseases, and hemophilia. They can be engineered for greater effectiveness and specific applications while maintaining their structural elements for immune targeting. Traditional immunoglobulin treatments have limited therapeutic uses and various adverse effects. That makes mAbs show rapid growth in the pharmaceutical market, with over 250 mAbs in clinical studies. Although mAbs offer higher specificity, they are less effective against complex antigens. They have become essential in treating diseases with limited medical options, providing innovative solutions that improve patients' quality of life through increasing survival rates, shortening the length of stay in hospitals with an improved treatment outcome, and reducing side effects. This review outlines the mechanisms, applications, and advancements of mAbs, highlighting their transformative role in modern medicine and their potential to shape future therapeutic interventions.
Microscopic Characterization Based Synthesis of Silver Nanoparticles Using Merremia quinquefolia (L.) Hallier f. Leaf Extract: Their Biological Approaches and Degradation of Methylene Blue Dye
Authors: Bharathi Arasangam , Saipraba Sivakumar , Ravichandran Devaraj , Meena Raji , Prakash Palanisamy , Gatasheh Mansour K. , Ahamed Anis , Murugesan Subban 
Published: January 2025

ABSTRACTThe green methods for the synthesis of silver nanoparticles (AgNPs) has developed popularity recently due to the low preparation costs, environmental friendliness, and non‐toxicity of the precursors. In this study, AgNPs were synthesized using leaf extract from Merremia quinquefolia. Spectroscopic techniques were used for analyzing the functional groups, morphology, crystalline phase, and elemental composition of nanomaterials. The ultraviolet (UV) visible spectrometry absorption spectra of the AgNPs had a surface plasmon resonance band at 459 nm and Fourier transformed infrared spectrum (FTIR) analysis showed the presence of elements groups. X‐ray diffraction (XRD) analysis indicates the crystalline structure and the energy‐dispersive x‐ray spectroscopy (EDAX) analysis shows strong signals for the silver element. Morphological analysis using transmission electron microscope (TEM) and scanning electron microscopy (SEM) analyses revealed that the AgNPs exhibited spherical shapes with an average size of 14 nm. Furthermore, it was indicated by the Raman spectra vibrational peak at 240 and 470 cm−1. The disk diffusion method showed that AgNPs were highly effective in inhibition of Gram‐positive bacteria Staphylococcus aureus with a high inhibitory zone (14 ± 0.23 mm). Antioxidant activity, the IC50 values for assays DPPH (145.7 μg/mL) and ABTS (112.09 μg/mL), and albumin denaturation in human red blood cells showed higher anti‐inflammatory activity. AgNPs had an IC50 value of 4.62 μg/mL against breast cancer (MCF‐7) cells. Methylene blue (MB) degrading studies were used to assess the photocatalytic activity of AgNPs. They are at 240 min observed sunlight, the MB degradation efficiency was 94.89%. Overall, although M. quinquefolia synthesizes AgNPs for environmentally friendly applications, the study is indicated to fully understand the potential involved in treating breast cancer cells.
Effects of Static and Low‐Frequency Magnetic Fields on Gene Expression
Authors: Zablotskii Vitalii , Gorobets Oksana , Gorobets Svitlana , Polyakova Tatyana 
Published: January 2025

Substantial research over the past two decades has established that magnetic fields affect fundamental cellular processes, including gene expression. However, since biological cells and subcellular components exhibit diamagnetic behavior and are therefore subjected to very small magnetic forces that cannot directly compete with the viscoelastic and bioelectric intracellular forces responsible for cellular machinery functions, it becomes challenging to understand cell–magnetic field interactions and to reveal the mechanisms through which these interactions differentially influence gene expression in cells. The limited understanding of the molecular mechanisms underlying biomagnetic effects has hindered progress in developing effective therapeutic applications of magnetic fields. This review examines the expanding body of literature on genetic events during static and low‐frequency magnetic field exposure, focusing particularly on how changes in gene expression interact with cellular machinery. To address this, we conducted a systematic review utilizing extensive search strategies across multiple databases. We explore the intracellular mechanisms through which transcription functions may be modified by a magnetic field in contexts where other cellular signaling pathways are also activated by the field. This review summarizes key findings in the field, outlines the connections between magnetic fields and gene expression changes, identifies critical gaps in current knowledge, and proposes directions for future research.Level of EvidenceNATechnical EfficacyStage 4
An Evaluation of Treatment Time and Intrafraction Motion in Stereotactic Body Radiation Therapy
Authors: Rough Leila , Burbery Julie , Hargrave Catriona , Brown Elizabeth 
Published: January 2025

ABSTRACTIntroductionImage guided‐radiation therapy (IGRT) protocols are adopted to ensure the accurate dose delivery of patient treatments. This is especially important in hypofractionated treatments, such as stereotactic body radiation therapy (SBRT), as high doses of radiation are delivered, and incorrect treatment can have a significant impact on tumour control and toxicity. This study aimed to establish mean treatment times from the localisation image to the post‐treatment image in SBRT liver, lung and spine patients that utilised Elekta Intrafraction Imaging (IFI). The magnitude of intrafraction motion exhibited as time elapses during the treatment fraction was also determined.MethodsIGRT data for 20 SBRT patients was retrospectively collected, including imaging times and shifts made from each pre‐, during and post‐treatment cone‐beam computed tomography (CBCT) scan. Total treatment fraction time, time between each image acquired and the 3D vector of the shifts were calculated. Descriptive statistical analysis was performed.ResultsThe IGRT data associated with 332 CBCT images was evaluated. The average treatment time was longest in the liver (19.3 min), followed by lung (14.9 min) and spine (14.2 min). Liver patients had a mean shift 3D vector (0.1 cm), with 7.8% of shifts > 0.3 cm. Lung patients had a mean vector of 0.1 cm with 3.8% > 0.3 cm, and spine patients had a mean vector of 0 cm with 0% > 0.2 cm. Vectors > 0.3 cm occurred at multiple imaging timepoints (range: 4.9–24.4 min) for liver and lung patients.ConclusionIntrafraction imaging is required in liver and lung SBRT treatments to identify instances where clinical tolerances are exceeded.
Comparative analysis of left bundle branch area pacing in patients with and without a history of open‐heart surgery
Authors: Nohno Yasumasa , Kozu Ryosuke , Ito Kii , Chikazawa Yuta , Maruyama Shusaku , Hasegawa Tomoya , Tsuchiya Hiromi , Tachibana Takahiro , Kimura Hikaru , Yazaki Yoshikazu 
Published: January 2025

AbstractBackgroundLeft bundle branch area pacing (LBBAP) is widely performed in routine clinical practice. Achieving LBBAP requires deep insertion of the lead into the interventricular septum. LBBAP may be challenging in patients with a history of open‐heart surgery (OHS) because of myocardial fibrosis associated with surgical trauma. This study aimed to report the feasibility and safety of performing LBBAP in patients with a history of OHS.MethodsThis retrospective analysis included patients who underwent successful LBBAP between November 2020 and September 2024, with approval from our institutional review board. LBBAP was performed using a 3830 SelectSecure lead, and pacing parameters were assessed before and after implantation.ResultsOne hundred patients were analyzed, including 26 in the OHS group and 74 in the non‐OHS group. The success rates of LBBAP were 84.6% in the OHS group and 90.5% in the non‐OHS group (p = 0.375). Notably, the number of LBBAP lead placements was higher in the OHS group (3.0 ± 2.1 vs. 2.0 ± 1.4, p = 0.017). The left ventricular activation time in lead V6 was comparable between the groups at implantation (73.6 ± 13.3 ms vs. 75.6 ± 12.1 ms, p = 0.522). The QRS duration was significantly wider in the OHS group at implantation (131.3 ± 14.6 vs. 121.1 ± 12.3 ms, p = 0.002), but parameters remained stable at 1 year.ConclusionsLBBAP in patients with a history of OHS may present a slightly higher level of technical difficulty, but it is both feasible and safe.
MTiTaO6: Cr3+ (M = Al3+, Ga3+, Sc3+) Phosphors with Ultra‐Broadband Excitation Spectra and Enhanced Near‐Infrared Emission for Solar Cells
Authors: Jiang Lipeng , Zhang Liangliang , Jiang Xue , Wang Jing , Zhang Junji , Jiang Weiwei , Li Guojun , Yu Hongbo , Si Wei , Shi Zhongxiang , Zhang Zhihua , Su Yanjing 
Published: January 2025

AbstractAchieving ultra‐broadband absorption and enhancing the near‐infrared (NIR) emitting properties of NIR phosphors is a key challenge to realize its multiple applications, such as solar spectrum conversion, spectral analysis, and night vision. Here, a novel NIR phosphor system MTiTaO6: Cr3+ (M = Al3+, Ga3+, Sc3+), with an excitation spectrum as broad as 421 nm and enhanced NIR emission is reported. It is the widest excitation spectrum among the known Cr3+‐doped NIR phosphors. Structural and spectroscopic analysis shows that the ultra‐broadband excitation spectrum originates from the overlap of multiple luminescence centers. Additionally, the emission peak is red‐shifted from 816 to 871 nm with increasing M ion radius, and the emission intensity is enhanced, which not only makes the emission spectra more compatible with the response curve of c‐Si solar cells, but also gives it an advantage in NIR spectroscopy applications. Comparison of the excitation spectra with the solar spectrum and spectral analysis of the emission spectra of water and alcohol demonstrate its promising applications.
Exploring the Impact of Non‐Ablative Erbium Laser Therapy on Recurrent Vaginal Candidiasis
Authors: Gaspar Adrian , Calderon Alicia , Mora Josue Vargas , Silva Joaquin , Bojanini Juan Fernando , Araujo Maria Jose , Geada Leticia Lazzaleta , Ivanova Elena , Helvacioglu Yeksin , Coello Pedro Peña , Zelaschi Delfina , Lucas Maria Fernanda , Mitraud Larissa , Carneiro Virginia , Cogorno Mariela , Mikić Aleksandra Novakov , Vasilescu Mihaela 
Published: January 2025

ABSTRACTObjectivesTo assess the effect of non‐ablative Er:YAG laser therapy on the symptoms and microbiological conditions of women with recurrent vulvovaginal candidiasis (RVVC).Materials and MethodsOne hundred and sixty‐seven women (mean age 34.1 ± 8.57 years) participated in this cohort study. Women diagnosed with RVVC received four vaginal laser therapies within 4 months. At baseline, 3 months, and 9 months after the last laser therapy microbiological assessment, improvement of five bothersome symptoms related to vaginal infection (burning, itching, dyspareunia, dysuria, and abnormal discharge), and the safety of the laser therapy and overall patient satisfaction were assessed.ResultsNon‐ablative vaginal Er:YAG laser therapy resulted in improvements of all bothersome symptoms and was statistically significant at 3 and 9 months following the therapy. A complete resolution in symptoms (VAS = 0) was observed in 38%–74% of women, depending on the symptom. Nine months after therapy, the prevalence of Candida albicans dropped from 80% to 30%, and a complete elimination of pathogens was detected in 64% of the women. The laser therapy appeared to be effective in the elimination of non‐albicans Candida species. A total of 86% of the patients reported being satisfied or very satisfied with the therapy. Only minor and transient adverse effects were recorded during the study.ConclusionNon‐ablative vaginal Er:YAG laser therapy proved to be a promising treatment for RVVC in women. The effect was achieved by improving their vaginal health by lowering the load of pathogenic yeast and by promoting the restoration of a favorable environment for normal microflora.
Self‐Assembly of Amphiphilic Polyphenylene Dendrimers with Different Surface Functionalization in Solvent/Non‐Solvent Mixtures
Authors: Weigold Svenja , Brödner Kerstin , John Torsten , Freudenberg Jan , Bunz Uwe H. F. , Weil Tanja , Fytas George , Müllen Klaus 
Published: January 2025

AbstractThis work compares the self‐assembly of nanometer‐sized amphiphilic Janus‐type and patched polyphenylene dendrimers (PPDs) in solvent/non‐solvent mixtures utilizing static and dynamic light‐scattering measurements. First‐ and second‐generation (G1 and G2) dendrimers are functionalized with substituents of different polarity, i.e., polar neo‐pentyl sulfonate or sulfonic acid groups are combined with non‐polar propyl groups. Neo‐pentyl sulfonate PPDs give rise to defined supramolecular assembly structures, irrespective of their amphiphilic surface functionalization or size. In contrast, the self‐assembly of PPDs with sulfonic acid substitution exhibits a pronounced dependence upon substitution pattern and generation. In particular, the Janus dendrimers demonstrate an increased tendency toward self‐assembly compared to their patched counterparts. This trend is more pronounced for G2 than for G1 PPDs.
Mussel‐Like Silk Fibroin Hydrogel With Skin Compliance Soft Electrode for Wearable Devices
Authors: Zhang Yonggen , Liu Andeng , Hao Wenzhe , Guo Wenxi , Xu Jun 
Published: January 2025

AbstractFlexible wearable electronic devices, capable of real‐time physiological monitoring for personalized health management, are increasingly recognized for their convenience, comfort, and customization potential. Despite advancements, challenges persist for soft electrodes due to the skin's complex surface, biocompatibility demands, and modulus mismatch. In response, a mussel‐inspired polydopamine‐nanoclay‐silk fibroin hydrogel (DA‐C‐SFH) is introduced, synthesized via a two‐step process. The initial polydopamine oxidation introduces free catechol groups through polydopamine‐incorporated nanoclay, followed by integration with silk fibroin, refining the fibroin network at the mesoscopic scale. This DA‐C‐SFH exhibits low modulus, high elasticity, adhesive properties, and biocompatibility, enabling conformal skin adhesion. It effectively detects subtle signals, such as pulse waves, and serves as a soft epidermal electrode, capable of recording various electrophysiological signals, including electrocardiograms and electromyograms, thus underscoring its potential in medical electronics and health monitoring applications.
Spatial–temporal variation of daily precipitation in different levels over mainland China during 1960–2019
Authors: Zhang Kexin , Wang Tiangui , Zhao Li , Peng Jiaoting , Ji Yan 
Published: January 2025

AbstractPrecipitation, essential for the water cycle and key to surface runoff and groundwater, causes floods and droughts when unevenly distributed. Understanding the variations in precipitation across China is vital for managing water resources and preventing weather‐related disasters. In this study, we analyzed the spatial–temporal variations in rainfall amounts and the number of rainy days across different levels in China using daily precipitation data during 1960–2019. We found a nonsignificant increase in annual total precipitation (ATP), but a significant decline in the number of days with ATP during this period. This shift suggests that precipitation is becoming more concentrated in fewer days, potentially due to an increase in the frequency of heavy rain (25 ≤ p < 50 mm/day, L3), rainstorm (50 ≤ p < 100 mm/day, L4), and heavy rainstorm (p > 100 mm/day, L5). The amount and frequency of precipitation in light rain (0.1 ≤ p < 10 mm/day, L1) and moderate rain (10 ≤ p < 25 mm/day, L2) exhibited a decreasing trend during this period, whereas the patterns for L3, L4, and L5 demonstrated an increasing trend. Notably, the decrease in the number of days with L1 and L2 precipitation was relatively minor compared with the substantial increase in the number of days experiencing L3, L4, and L5 precipitation. Despite L1 precipitation making up only 24.9% of China's ATP, it accounts for 78.6% of total precipitation days. This underscores the important role played by L1 precipitation events in determining the overall frequency of precipitation occurrences in China. Significant regional disparities are observed in both precipitation amounts and the number of precipitation days across different precipitation levels. Furthermore, large‐scale climate indices have consistently affected China's precipitation patterns since 1960, impacting not just the current year but possibly extending into the subsequent year.