bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Informasi Akuntansi Dalam Meningkatkan Nilai Perusahaan Serta Implikasinya Pada Tanggung Jawab Kepada Stakeholder
Authors: Oktariani Riska , Orinaldi Mohammad , Fikri Atar Satria 
Published: December 2023

Riset ini bertujuan guna menilai dampak langsung informasi akuntansi pada peningkatan nilai perusahaan serta tanggung jawab kepada stakeholder. Variabel independen yang dipergunakan yaitu informasi akuntansi biaya yang diproksikan sebagai biaya produksi, variabel dependennya yaitu beban bunga dan beban pajak, dan variabel interveningnya yaitu nilai perusahaan yang diproksikan pada nilai kapitalisasi pasar. Data sekunder yang dipergunakan berupa laporan keuangan perusahaan sub sektor makanan dan minuman yang terdaftar di ISSI periode 2020-2022. Risetini ialah riset deskriptif dengan pendekatan kuantitatif, dengan sampel sejumlah 18 perusahaan dengan metode purposive sampling. Teknik analisis data yaitu analisis jalur. Hasil analisa memperlihatkan adanya dampak langsung dan signifikan biaya produksi (X) pada nilai perusahaan (Z), adanya dampak langsung signifikan nilai perusahaan (Z) pada beban bunga (Y1), adanya dampak langsung signifikan nilai perusahaan (Z) pada beban pajak (Y2) serta tidak adanya dampak tidak langsung signifikan biaya produksi (X) pada beban bunga (Y1) melalui nilai Perusahaan dan tidak adanya dampak tidak langsung signifikan biaya produksi (X) pada beban pajak (Y2) melalui nilai Perusahaan.
Рішення бенчмарка Х2 щодо визначення ізотопного складу відпрацьованого ядерного палива ВВЕР-1000 з використанням пакета програм SCALE
Authors: Kovbasenko Yu. , Bilodid Ye. 
Published: December 2023

З використанням даних розрахункового бенчмарка Х2 проведено аналіз похибки розрахунків коефіцієнта розмноження нейтронів та ізотопного складу відпрацьованого ядерного палива реактора ВВЕР‑1000 під час його опромінення в активній зоні реактора за допомогою програмних модулів CSAS6 та TRITON пакета програм SCALE.
Бенчмарк Х2 було розроблено для моделювання нейтронно-фізичних характеристик ядерного палива та активної зони реактора ВВЕР-1000 за експлуатаційними даними енергоблока № 2 Хмельницької АЕС (Україна).
Розрахунки проводилися з використанням детальної тривимірної моделі реакторної чарунки зі штатною паливною збіркою реактора ВВЕР‑1000 типу ТВЗ-А, розробленої для пакета програм SCALE. Відповідно до матеріалів бенчмарка були використані номінальні значення геометричних та матеріальних параметрів ТВЗ-А, а також номінальні умови опромінення палива в активній зоні енергоблока № 2 Хмельницької АЕС.
Було виконано розрахунки з визначення коефіцієнта розмноження нейтронів реакторної чарунки та ізотопного складу ядерного палива залежно від глибини вигоряння в діапазоні 0 – 60 МВт∙діб/кгU. Відповідно до матеріалів бенчмарка були визначені концентрації в опроміненому паливі 9 ізотопів: 235U, 238U, 239Pu, 240Pu, 241Pu, 155Gd, 157Gd, 135Xe та 149Sm залежно від глибини вигоряння палива.
Результати розрахунків нейтронно-фізичних характеристик сучасного відпрацьованого ядерного палива реактора ВВЕР-1000 з використанням пакета програм SCALE показують дуже хороший збіг з результатами бенчмарка.
Ефективність лікування експериментального алергічного контактного дерматиту новою комбінованою фармацевтичною композицією
Authors: Дембіцька Е. С. , Кононенко Н. М. , Цубанова Н. А. 
Published: December 2023

У статті наведено результати дослідження нової комбінованої фармацевтичної композиції за умов експериментального алергічного контактного дерматиту в мурчаків. Пошук нових оригінальних лікарських засобів з антиалергічною дією залишається актуальним питанням сучасної медицини та фармації в зв’язку зі значним поширенням алергічних захворювань серед населення. Ученими Національного фармацевтичного університету було розроблено нову комбіновану фармацевтичну композицію – антиалергічний комбінований рослинний засіб (АКРЗ), що містить стандартизовані екстракти трави череди трироздільної, квіток нагідок, листя та квіток глоду.
Мета дослідження – вивчити вплив АКРЗ на гістоструктуру шкіри мурчаків з моделлю алергічного контактного дерматиту.

Алергічний контактний дерматит викликали нанесенням 5 % спирто-ацетонового розчину 2,4-динітрохлорбензолу (ДНХБ) на ділянку шкіри мурчаків. АКРЗ вводили в дозі 30 мг/кг, препарат порівняння Дезлоратадин вводили в дозі 0,30 мг/кг, препарат порівняння Тесалін – у дозі 7,2 мг/кг. Досліджувану композицію та препарати порівняння вводили тваринам внутрішньошлунково протягом 10 днів. Ефективність препаратів оцінювали за впливом на гістоструктуру шкіри експериментальних тварин.
Встановлено, що новий АКРЗ у дозі 30 мг/кг чинить значну антиалергічну дію за умов алергічного контактного дерматиту в мурчаків. За виразністю позитивного впливу на гістоструктуру шкіри мур- чаків з алергічним контактним дерматитом засоби на основі лікарських рослин, АКРЗ і Тесалін, дещо поступаються антигістамінному препарату Дезлоратадину. АКРЗ за антиалергічною дією перевищує ефективність препарату порівняння Тесаліну.
Таким чином, АКРЗ чинить антиалергічну дію, що встановлено за позитивним впливом на гістоструктуру шкіри мурчаків з алергічним контактним дерматитом.
Penyuluhan Formulasi Spray Anti Nyamuk dari Infusa Limbah Daun Serai (Cymbopogon nardus) dan Kulit Buah Jeruk Nipis (Citrus aurantifolia)
Authors: Dipahayu Damaranie , Annurijati Siti 
Published: December 2023

Dengue fever is endemic in Indonesia. Using mosquito repellent is an effective way to prevent mosquito bites. This community service is in the form of webinar “the formulation of an anti-mosquito spray used infusion method of lemongrass (Cymbopogon nardus) leaf and lime peel (Citrus aurantifolia)”. Natural formula is safer than chemicals especially for children. The audiences of this counseling are the parents and teachers of KB-RA Perwanida's. Counseling accompanied by video playback of formulations and question and answer discussions. The mosquito repellent spray had an attractive color, fresh aroma and moisture on the skin. The audiences stated that the webinar was very useful so that it was usefull and meet the target
Online Course: Factors Influencing Students’ Decision
Authors: Maya Dora Yenny , Rizkie Widokarti Joko , Ismail Andy , Buana Dwinto Martri Aji 
Published: December 2023

Purpose – This research aims to analyze the factors that influence students' decision-making in order to continue choosing online learning methods after the COVID-19 pandemic.
Methodology – The research method was quantitative research using survey research techniques. The research sample included 375 students who were currently enrolled in university and had attended online courses. The collected data will be analyzed using SEM Amos.
Result – The results of data processing and analysis revealed that the factor influencing students' decisions to continue choosing online learning methods was students' attitudes towards online learning methods. Because there was a strong incentive to choose online lectures if the student's attitude was positive. In addition, students' decisions to choose online learning methods in the post-COVID-19 pandemic will be heavily influenced by their experience taking online lectures during the COVID-19 pandemic. Therefore, experience influences student attitudes, perceptions, and motivation.
Originality – This research used Attitude, Perception, Motivation, and Experience as mediators to analyze students' decisions to continue choosing online learning methods. In addition to perception and motivation, attitude and experience factors as mediators can help to understand the factors that most influence student decisions.
ANÁLISE DO PERFIL ACADÊMICO E QUANTITATIVO DE ESTUDANTES UNIVERSITÁRIOS COM DEFICIÊNCIA DE UMA UNIVERSIDADE ESTADUAL DO PARANÁ EM RELAÇÃO AOS DADOS DO CENSUP 2019
Authors: Struginski Pereira Gabriele , França Mosquera Carlos Fernando 
Published: December 2023

O ingresso de alunos com deficiência nas universidades tem se tornado cada vez mais frequente, contudo, ainda é difícil traçar um panorama completo desses estudantes. Essa pesquisa apresenta uma análise e comparação entre matrículas de alunos com deficiência de uma Universidade Estadual do Paraná e dados coletados do Censo da Educação Superior de 2019 (Censup), juntamente com informações obtidas do Plano Nacional de Saúde (PNS) do mesmo ano. Trata-se de uma pesquisa de cunho quantitativo e exploratório, que considerou a identificação de matrículas de alunos com deficiência no ano de 2019. Os dados foram analisados utilizando a Estatística Descritiva. Conclui-se que o número de matrículas de alunos com deficiência na Universidade Estadual pública do Paraná e no Brasil ainda é pequeno, quando comparados com o restante das matrículas, mas o número é crescente quando comparado com anos anteriores, quando o assunto é a matrícula destes alunos. Sugere-se que uma melhor planificação no levantamento destes dados na universidade pública possa ser um caminho para fortalecer as políticas afirmativas e institucionais, como um aumento de projetos de apoio aos alunos com deficiência proveniente do Centro de Educação e Direitos Humanos da universidade, fundamental para garantir a participação destes alunos na universidade pública.
Palavras – Chave: Universidade. Inclusão. Censo da Educação Superior
Mitochondrial DNA copy number in patients with systemic sclerosis
Authors: Bogatyreva Anastasia I. , Gerasimova Elena V. , Kirichenko Tatiana V. , Markina Yuliya V. , Tolstik Taisiya V. , Kiseleva Diana G. , Popkova Tatiana V. , Markin Alexander M. 
Published: December 2023

Introduction: Systemic scleroderma (SSc) is a chronic autoimmune disease of inflammatory origin. Mitochondrial dysfunction is considered as an important mechanism in the pathogenesis of SSc. Currently mitochondrial DNA (mtDNA) copy number is used as a surrogate marker of mitochondrial dysfunction. Previous studies demonstrate that innate immune cells are important participants in inflammatory and fibrotic processes in SSc. The aim of the study was to evaluate the number of mtDNA copies in CD14+ monocytes and whole blood of patients with SSc in comparison with healthy individuals.Methods: Absolute mtDNA copy number was measured using digital PCR. It was found that the number of mtDNA copies in CD14+ monocytes was significantly higher in patients with SSc compared to control, while the number of mtDNA copies in the whole blood did not have significant differences.Results: The correlation analysis revealed an inverse association of mtDNA copy number with disease duration and the relationship between pro-inflammatory activation of CD14+ monocytes in terms of LPS-stimulated IL-6 secretion and mtDNA copy number. At the same time, basal and LPS-stimulated secretion of IL-6 by cultured CD+ monocytes were significantly higher in SSc group in comparison with control.Discussion: The study results suggest that increase of mtDNA copy number in CD14+ monocytes is a possible mechanism to maintain the reduced function of defective mitochondria in monocytes from patients with SSc associated with the development and progression of SSc.
Amyotrophic lateral sclerosis and osteoporosis: a two-sample Mendelian randomization study
Authors: Li Junhong , Ma Cong , Huang Hui , Liao Hui 
Published: December 2023

BackgroundA few observational studies revealed that amyotrophic lateral sclerosis (ALS) was tightly connected with osteoporosis. However, the results of previous studies were inconsistent, and the causal effect of ALS on osteoporosis has not been investigated. To do so, the two-sample Mendelian randomization (MR) method was employed to estimate the causality.MethodsThe instrumental variables (IVs) for ALS were selected from one GWAS summary dataset (27,205 ALS cases and 110,881 controls), and bone mineral density (BMD) in the femoral neck (FN), lumbar spine (LS), and forearm, extracted from another large-scale GWAS summary database (53,236 cases), were used as phenotypes for osteoporosis. Random-effects inverse variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode were conducted to evaluate the causality. Sensitivity analyses were further performed to explore heterogeneity and pleiotropy.ResultsA total of 10 qualified SNPs were finally selected as proxies for ALS. The results of random effects from IVW revealed that ALS has no causal effect on FN-BMD (beta: −0.038, 95% CI: −0.090 to 0.015, SE: 0.027, p = 0.158), LS-BMD (beta: −0.015, 95% CI: −0.076 to 0.046, SE: 0.031, p = 0.629), and forearm BMD (beta: 0.044, 95% CI: −0.063 to 0.152, SE: 0.055, p = 0.418). These results were confirmed using the MR-Egger, weighted median, simple model, and weighted model. No heterogeneity or pleiotropy was detected (p &gt; 0.05 for all).ConclusionContrary to previous observational studies, our study figured out that no causal effect existed between ALS and osteoporosis. The disparity in results is probably attributed to secondary effects such as physical inactivity and muscle atrophy caused by ALS.
Causal relationships between human blood metabolites and intracranial aneurysm and aneurysmal subarachnoid hemorrhage: a Mendelian randomization study
Authors: Jiang Jia , Gui Siming , Wei Dachao , Chen Xiheng , Tang Yudi , Lv Jian , You Wei , Chen Ting , Yang Shu , Ge Huijian , Li Youxiang 
Published: December 2023

ObjectiveThe aim of this study was to assess the causal relationships between blood metabolites and intracranial aneurysm, aneurysmal subarachnoid hemorrhage, and unruptured intracranial aneurysm.MethodsOur exposure sample consisted of 7,824 individuals from a genome-wide association study of human blood metabolites. Our outcome sample consisted of 79,429 individuals (7,495 cases and 71,934 controls) from the International Stroke Genetics Consortium, which conducted a genome-wide association study of intracranial aneurysm, aneurysmal subarachnoid hemorrhage, and unruptured intracranial aneurysm. We identified blood metabolites with a potential causal effect on intracranial aneurysms and conducted sensitivity analyses to validate our findings.ResultsAfter rigorous screening and Mendelian randomization tests, we found four, two, and three serum metabolites causally associated with intracranial aneurysm, aneurysmal subarachnoid hemorrhage, and unruptured intracranial aneurysm, respectively (all P &lt; 0.05). Sensitivity analyses confirmed the robustness of these associations.ConclusionsOur Mendelian randomization analysis demonstrated causal relationships between human blood metabolites and intracranial aneurysm, aneurysmal subarachnoid hemorrhage, and unruptured intracranial aneurysm. Further research is required to explore the potential of targeting these metabolites in the management of intracranial aneurysm.
Subjective cognitive complaints in patients with progressive supranuclear palsy
Authors: Lee Jun Seok , Ahn Jong Hyeon , Ha Jong Mok , Youn Jinyoung , Cho Jin Whan 
Published: December 2023

IntroductionSubjective cognitive complaints (SCC) refer to self-reported cognitive decline that may or may not be reflected in objective neuropsychological evaluations. Such SCC are prevalent in neurodegenerative diseases, including Parkinson’s disease (PD), but the prevalence and clinical features in patients with progressive supranuclear palsy (PSP) have not been investigated.MethodsWe recruited 83 PSP patients without dementia and investigated their SCC using a semi-structured interview. Comprehensive neuropsychological test results and patient clinical features were compared according to presence of SCC and underlying cognitive state.ResultsAmong the 83 patients, 16 had normal cognition (NC), 67 had mild cognitive impairment (MCI), and 36 (43.4%) reported SCC. Among NC patients, 37.5% (6/16) had SCC, while 44.8% (30/67) of MCI patients reported SCC. There were no differences between the neuropsychological test results or demographic and clinical characteristics of PSP patients with or without SCC in the NC group. The demographic and clinical characteristics of the MCI+SCC (MCI with SCC)and MCI-SCC (MCI without SCC) groups were comparable, but the MCI+SCC group had significantly worse neuropsychological scores than the MCI-SCC group, particularly in tests assessing attention, language, visual memory, and fronto-executive function domains.DiscussionWhile SCC are commonly reported by PSP patients, patients with PSP and MCI+SCC had worse cognitive function than those who did not report SCC. These findings suggest that SCC in PSP patients with MCI could be a worsening sign of cognitive function. Therefore, it is crucial for physicians to assess SCC in PSP patients and to provide timely diagnosis and management of cognitive decline.
Case report: A case of primary angiitis of the central nervous system: misdiagnosed for 3.5 years
Authors: Qin Lixia , He Miao , Lu Wei 
Published: December 2023

IntroductionPrimary angiitis of the central nervous system (PACNS) is an uncommon inflammatory condition that exclusively affects blood vessels within the brain parenchyma, leptomeninges, and spinal cord. Due to its infrequency and the variability in its clinical presentation and imaging findings, diagnosing PACNS can be challenging.Case descriptionIn this study, we present the case of a teenager who initially presented with headaches and epilepsy. Comprehensive laboratory tests yield normal results. A series of brain magnetic resonance imaging (MRI) revealed a progression of changes, starting from localized cerebral atrophy and culminating in the development of a contrast-enhanced mass with vasogenic edema. Immune-associated encephalitis and mitochondrial encephalopathy were suspected, but immunologic investigations, mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) sequencing using biopsied muscle, and muscle pathologies were all negative. Ultimately, a diagnosis of PACNS was confirmed through a stereotactic brain biopsy, which took place 3.5 years after the onset of symptoms. The patient responded favorably to treatment with glucocorticoids and cyclophosphamide.ConclusionIn summary, we have described a case of PACNS characterized by localized cerebral atrophy and tumor-like MRI findings, who was misdiagnosed as immune-associated encephalitis or mitochondrial encephalopathy for 3.5 years. We emphasize the importance of dynamic observation of MRI changes, as well as brain biopsy.
A scientifically validated combination of garcinol, curcuminoids, and piperine for mild to moderate nonalcoholic steatohepatitis patients—results from a randomized, double-blind, placebo-controlled study
Authors: Majeed Muhammed , Nagabhushanam Kalyanam , Noureddin Mazen , Paulose Shaji , Barik Chinmoy , Saklecha Santosh , Mundkur Lakshmi 
Published: December 2023

BackgroundGarcinol is a naturally occurring compound from the fruit rind of the Garcinia indica, with antioxidant, anti-inflammatory, and anticancer properties. Curcuminoids are the active molecule from the rhizome of Curcuma longa, studied extensively for its health benefits as an anti-inflammatory and antioxidant activities. Non-alcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic steatohepatitis characterized by liver fat and inflammation.ObjectiveTo evaluate the clinical efficacy and safety of Garcinol, Curcuminoids and piperine (GCP) combination in patients with mild to moderate NASH in a randomized, double-blind, placebo-controlled study.MethodsThe patients received one tablet (450 mg) of GCP containing garcinol-50 mg, curcuminoids −250 mg and piperine 5 mg or a placebo (450 mg of microcrystalline cellulose) twice daily for 90 days. Changes in circulating aspartate aminotransferase (AST), alanine transaminase (ALT) levels, liver stiffness measurement (LSM), and controlled attenuation parameter (CAP) using Fibroscan were compared from baseline to day 90. Anthropometric parameters, serum levels of lipids, Interleukin (IL-6), hsCRP, and adiponectin were estimated. Safety was evaluated by laboratory parameters and by monitoring adverse events.ResultsSeventy-two patients were randomized and 63 (GCP = 32, Placebo = 31) completed the study. The mean age of the patients was 48.3 ± 8.7 years (36 males and 27 females). The mean reduction in AST (U/L) was 9.53 in GCP and 3.16 in placebo (p &lt; 0.001) and that of ALT (U/L) was 13.47 in GCP and 7.43 in Placebo (p = 0.002). The liver stiffness and CAP scores showed a better reduction in GCP (0.56 kPa and 12.38 db/m) compared to placebo (0.064 kPa and 10.42 db/m) p &lt; 0.05. Consequently, the noninvasive Fibroscan-AST (FAST) score reduction was also found to be significant in GCP compared to placebo. Additionally, body weight, lipid levels, hsCRP, and IL-6 in serum decreased, while adiponectin levels increased in GCP-supplemented participants compared to placebo. The combination of garcinol and curcuminoids was well tolerated with no significant changes in hematological and clinical laboratory parameters during the 90-day supplementation.ConclusionOur results suggest that GCP could be a possible supplement for the management of NASH.Clinical trial registration: https://clinicaltrials.gov/, identifier CTRI/2019/11/022147.
Restaurants’ compliance with calorie labeling policies in food delivery applications
Authors: Alangari Abdulaziz S. 
Published: December 2023

BackgroundTo encourage consumers to make healthier choices, the Saudi Food and Drug Authority (SFDA) released the Saudi Arabia Nutrition Labeling Policy, which requires restaurants to present caloric information clearly on their menus. Food delivery applications are also mandated to present caloric information on their platforms. The aim of this study is to explore how restaurants on food delivery applications comply with the calorie labeling policy.MethodsData were extracted from a widely used food delivery application in Saudi Arabia to include a sample of 120 “healthy food” restaurants. The restaurants were checked for compliance on both the application and the website. Descriptive and logistic regression analyses were performed to examine the distribution and association of relevant factors.ResultsA substantial proportion (43.3%) of healthy foods on delivery applications (n = 120) do not comply with the SFDA calorie labeling policies. Among these restaurants, 56.5% presented the calorie labeling on their menu item. Of those who provided calorie information on their websites (n = 62), 54.8% provided appropriate calorie labeling based on the SFDA policy. There was an association between compliance and the number of restaurant categories but no associations for website calorie labeling, rating, and appropriateness.ConclusionThis study provides important findings for policymakers that will enable them to reinforce food calorie policies on food delivery platforms, restaurant websites, social media, and marketing campaigns. Not all restaurants comply with the SFDA calorie labeling policies. Suggestions to present the calorie-related words in Arabic and offer more information to help the consumer make the appropriate food selection decision. Further studies are needed to explore the reasons for and barriers to posting nutritional information on menu items.