bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term conservative treatment outcomes for midshaft clavicle fractures: a 10-to-30-year follow-up
Authors: Matsubara Yuki , Nakamura Yoshihiro , Sasashige Yoshiaki , Yokoya Shin , Adachi Nobuo 
Published: December 2023

Abstract
Background
Few reports exist on the long-term outcomes of midshaft clavicle fracture conservative treatments. Therefore, this study investigated the long-term outcome of this treatment in patients with midshaft clavicle fractures.

Methods
Patients were treated conservatively for midshaft clavicle fractures with a figure-of-eight bandage between 10 and 30 years ago. Subsequently, a telephone survey was used to follow-up these patients, and 38 were successfully evaluated. The mean term after trauma was 17.0 years. Afterward, the American Shoulder and Elbow Surgeons Shoulder (ASES) score and Shoulder pain and disability index (SPADI) on the affected and unaffected sides were calculated based on the filled questionnaires. We defined patients whose ASES and SPADI on the affected side were worse than the unaffected side as the symptomatic group. Furthermore, plain radiographs measured proportional changes in clavicular length and displacement.

Results
The ASES scores of the affected side were significantly lower than those of the unaffected side, and the SPADI of the affected side was significantly higher than that of the unaffected side. Furthermore, the symptomatic group's proportional changes in clavicular length and displacement were significantly larger than the asymptomatic group.

Conclusion
The affected shoulder side was more symptomatic than the unaffected side 10 to 30 years after the trauma when midshaft clavicle fractures were treated conservatively. Moreover, several patients became symptomatic for fractures with a larger proportional change in clavicular length or displacement.
Mosquito control exposures and breast cancer risk: analysis of 1071 cases and 2096 controls from the Ghana Breast Health Study
Authors: Olivos Naomie , Banta Jim E. , Spencer-Hwang Rhonda , Ansong Daniel , Beane Freeman Laura E. , Clegg-Lamptey Joe-Nat , Wiafe-Addai Beatrice , Edusei Lawrence , Adjei Ernest , Titiloye Nicholas , Dedey Florence , Aitpillah Francis , Oppong Joseph , Vanderpuye Verna , Osei-Bonsu Ernest , Ahearn Thomas U. , Biritwum Richard , Yarney Joel , Awuah Baffour , Nyarko Kofi , Garcia-Closas Montserrat , Abubakar Mustapha , Brinton Louise A. , Figueroa Jonine D. , Wiafe Seth 
Published: December 2023

AbstractEpidemiologic data on insecticide exposures and breast cancer risk are inconclusive and mostly from high-income countries. Using data from 1071 invasive pathologically confirmed breast cancer cases and 2096 controls from the Ghana Breast Health Study conducted from 2013 to 2015, we investigated associations with mosquito control products to reduce the spread of mosquito-borne diseases, such as malaria. These mosquito control products were insecticide-treated nets, mosquito coils, repellent room sprays, and skin creams for personal protection against mosquitos. Multivariable and polytomous logistic regression models were used to estimate odds ratios (ORadj) and 95% confidence intervals (CI) with breast cancer risk-adjusted for potential confounders and known risk factors. Among controls, the reported use of mosquito control products were mosquito coils (65%), followed by insecticide-treated nets (56%), repellent room sprays (53%), and repellent skin creams (15%). Compared to a referent group of participants unexposed to mosquito control products, there was no significant association between breast cancer risk and mosquito coils. There was an association in breast cancer risk with reported use of insecticide-treated nets; however, that association was weak and not statistically significant. Participants who reported using repellent sprays were at elevated risks compared to women who did not use any mosquito control products, even after adjustment for all other mosquito control products (OR = 1.42, 95% CI=1.15–1.75). We had limited power to detect an association with repellent skin creams. Although only a few participants reported using repellent room sprays weekly/daily or < month-monthly, no trends were evident with increased frequency of use of repellent sprays, and there was no statistical evidence of heterogeneity by estrogen receptor (ER) status (p-het > 0.25). Our analysis was limited when determining if an association existed with repellent skin creams; therefore, we cannot conclude an association. We found limited evidence of risk associations with widely used mosquito coils and insecticide-treated nets, which are reassuring given their importance for malaria prevention. Our findings regarding specific breast cancer risk associations, specifically those observed between repellent sprays, require further study.
SIMPD: an algorithm for generating simulated time splits for validating machine learning approaches
Authors: Landrum Gregory A. , Beckers Maximilian , Lanini Jessica , Schneider Nadine , Stiefl Nikolaus , Riniker Sereina 
Published: December 2023

AbstractTime-split cross-validation is broadly recognized as the gold standard for validating predictive models intended for use in medicinal chemistry projects. Unfortunately this type of data is not broadly available outside of large pharmaceutical research organizations. Here we introduce the SIMPD (simulated medicinal chemistry project data) algorithm to split public data sets into training and test sets that mimic the differences observed in real-world medicinal chemistry project data sets. SIMPD uses a multi-objective genetic algorithm with objectives derived from an extensive analysis of the differences between early and late compounds in more than 130 lead-optimization projects run within the Novartis Institutes for BioMedical Research. Applying SIMPD to the real-world data sets produced training/test splits which more accurately reflect the differences in properties and machine-learning performance observed for temporal splits than other standard approaches like random or neighbor splits. We applied the SIMPD algorithm to bioactivity data extracted from ChEMBL and created 99 public data sets which can be used for validating machine-learning models intended for use in the setting of a medicinal chemistry project. The SIMPD code and simulated data sets are available under open-source/open-data licenses at github.com/rinikerlab/molecular_time_series.
Analysis of exogenous lactic acid bacteria on growth and development of different herbaceous peony varieties and rhizosphere soil nutrients
Authors: Yang Xiao , Yang Lijin , Shi Yajie , Lei Fuling , Dong Lingling , Zheng Chengshu , Zhang Dongliang , Sun Limin , Xie Anqi , Sun Xia 
Published: December 2023

AbstractThere are replanting problems in the production of herbaceous peony. If ramet seedlings are replanted in the original planting hole, they weaken year-by-year until their death, which reduces the land utilisation rate and increases the production costs. In this study, exogenous lactic acid bacteria (LAB, the main component is Lactobacillus plantarum) were applied to improve the planting soil of herbaceous peony for the first time to alleviate the replanting problems, to reduce the production costs, and to provide a new way to promote the of the herbaceous peony industry. In this study, herbaceous peony main cultivars varieties ‘Dafugui’ ‘Hongxiuqiu’ and ‘Zifengyu’ were selected, and experiments were conducted using exogenous LAB. Morphological, rhizosphere soil, and root physiology indexes were measured by sampling at the end of the high-growth periods of herbaceous peony. The results showed that after LAB treatment, the plant height, flowering rate, other morphological indexes and root vitality of ‘Hongxiuqiu’ were increased, with a better promoting effect than that of ‘Dafugui’ and ‘Zifengyu’. The ‘Dafugui’ rhizosphere soil nutrient content and enzyme activity were improved, followed by ‘Hongxiuqiu’ and ‘Zifengyu’. The rhizosphere soil free salicylic acid content and root abscisic acid content decreased, whereas the soil bacterial abundance, root antioxidant enzyme activity, proline and paeoniflorin content increased in all varieties. This study found that LAB application can improve soil fertility and enzyme activity, promote the growth and development of herbaceous peony, increase the flowering rate and improve the ornamental value. However, the influence of LAB on different herbaceous peony varieties varied. Therefore, it is necessary to further expand the number of varieties, optimise the application concentration and frequency of LAB application, alleviate the replanting problems in herbaceous peony production, improve the utilisation rate of land, promote excellent varieties of herbaceous peony, and provide a new methods and references.
Graphical abstract
Engaging communities to inform the development of a diverse cohort of cancer survivors: formative research for the eat move sleep study (EMOVES)
Authors: Andemeskel Ghilamichael , Palmer Nynikka R. , Pasick Rena , Van Blarigan Erin L. , Kenfield Stacey A. , Graff Rebecca E. , Shaw Michael , Yu Wil , Sanchez Mayte , Hernandez Roberto , Washington Samuel L. , Shariff-Marco Salma , Rhoads Kim F. , Chan June M. 
Published: December 2023

Abstract
Background
There are more than 18 million cancer survivors in the United States. Yet, survivors of color remain under-represented in cancer survivorship research (Saltzman et al. in Contemp Clin Trials Commun 29:100986, 2022; Pang et al. in J Clin Oncol 34:3992–3999, 2016; Lythgoe et al. in Prostate Cancer Prostatic Dis 24:1208–1211, 2021). Our long-term goal is to enroll and follow a cohort of historically under-represented cancer survivors, to better understand modifiable risk factors that influence clinical and quality of life outcomes in these populations. Towards that goal, we describe herein how we applied community-based participatory research approaches to develop inclusive study materials for enrolling such a cohort.

Methods
We implemented community engagement strategies to inform and enhance the study website and recruitment materials for this cohort including: hiring a dedicated engagement coordinator/community health educator as a member of our team; working with the Helen Diller Family Comprehensive Cancer Center Office of Community Engagement (OCE) and Community Advisory Board members; presenting our educational, research, and study recruitment materials at community events; and establishing a community advisory group specifically for the study (4 individuals). In parallel with these efforts, 20 semi-structured user testing interviews were conducted with diverse cancer survivors to inform the look, feel, and usability of the study website.

Results
Engagement with community members was a powerful and important approach for this study’s development. Feedback was solicited and used to inform decisions regarding the study name (eat move sleep, EMOVES), logo, study website content and imagery, and recruitment materials. Based on community feedback, we developed additional educational materials on healthy groceries and portion size in multiple languages and created a study video.

Conclusions
Including an engagement coordinator as a permanent team member, partnering with the institutional community outreach and engagement resources (i.e., OCE), and allocating dedicated time and financial support for cultivating relationships with stakeholders outside the university were critical to the development of the study website and materials. Our community guided strategies will be tested as we conduct enrollment through community advisor networks and via the state cancer registry.
A rare case report of frontoethmoidal encephalocele in a neonate
Authors: Kibru Ermias Algawork , Mogessie Yidnekachew Girma 
Published: December 2023

Abstract
Background
The protrusion of cranial contents via a skull defect is known as an encephalocele. Unlike western countries where occipital encephalocele dominates, anterior encephaloceles are the most common types of encephalocele in Southeast Asia, parts of Russia, and Central Africa. We present the clinical presentation and surgical management of an 8-day-old infant with frontoethmoidal encephalocele.

Case presentation
An 8-day-old neonate born to a 24-year-old mother with no antenatal follow-up was referred with a compliant of frontonasal swelling which was present since birth. Physical examination of the neonate revealed a cystic lobulated swelling over the upper edge of the nasal bridge. Computed tomography imaging showed an anterior skull defect, resulting in frontonasal meningoencephalocele. The patient underwent a one-stage operation, which combined nasal-coronal approach with frontal craniotomy, to remove the dysplastic tissue and reconstruct the defect. The patient had successful recovery period with acceptable cosmesis.

Conclusion
We presented a case of frontoethmoidal encephalocele, which is rare in western countries but whose incidence is relatively higher in African countries. Perinatal care is necessary for prevention and early detection of such cases. Direct surgical repair is still the main mode of intervention.
Polyphenol-based antibacterial and antioxidative nanoparticles for improved peritonitis therapy
Authors: Dong Jinhong , Wang Tianyou , Li Haotian , Zhang Jianhua , Zhang Hengjie , Liu Weijie , You Xinru , Gu Zhipeng , Li Yiwen , Chen Xianchun , Fu Qiang 
Published: December 2023

AbstractThe development of advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications is highly desirable. In the present investigation, biomass-based nanoparticles (NPs) were assembled through the Mannich reaction between the plant polyphenols and the broad-spectrum antibiotic tigecycline (TG). The fabricated NPs with uniform size demonstrated excellent oxidative balance effects, pH-responsive release properties and antibacterial performances. Furthermore, the intracellular and in vivo studies confirmed that the NPs are capable of reducing oxidative damage to cells and significantly repairing tissue injury in mice with peritonitis. This work presents an effective method and idea for constructing biomass-based materials for the treatment of infection-induced diseases.
Graphical Abstract
Impact of family history of cancer on colorectal cancer screening: a propensity score-matched analysis from the Health Information National Trends Survey (HINTS)
Authors: Akonde Maxwell , Mishio Bawa Eric , Dakurah Ottovon Bismark , Das Gupta Rajat 
Published: December 2023

Abstract
Background
Early detection of colon cancer leads to better survival outcomes. This can be achieved through colorectal cancer (CRC) screening. People with a family history of cancer (FHC) have increased risk of developing CRC. Increasing screening in this group will reduce CRC mortality. This study evaluated CRC screening in people with FHC.

Methods
The study used data from the Health Information National Trends Survey (HINTS) 5, cycle 3. This is an annual cross-sectional survey with a nationally representative sample of American adults. The objective was to study the association between FHC and performing CRC screening. Propensity score matching was used to create a matched population with variables that constituted beliefs in cancer from the survey. Replication procedure, which is based on repeated sampling and allows for accurate computation of standard errors, was used for calculating statistical tests. Multivariable models were fitted in the matched population to assess the association between FHC and performing CRC screening.

Results
People with FHC were 14% (OR = 1.14; 95% CI: 0.81–1.60) more likely to perform CRC screening than those without FHC, even though not statistically significant. Age in years (OR = 1.14; 95% CI: 1.12–5.27) had increased likelihood of performing CRC screening, while other races such as American Indians/Alaskan Natives (except African Americans) compared to Caucasians (OR = 0.49; 95% CI: 0.29–0.84) had significantly decreased likelihood of performing CRC screening.

Conclusion
FHC was not significantly associated with having a colorectal cancer screening test. Public health advocacy should be directed towards increasing awareness of CRC screening among people with FHC.
COVID-19-related health literacy and preparedness to what may come: a cross-sectional study
Authors: Moustafa Hebatallah Ahmed Mohamed , Kassem Amira B. 
Published: December 2023

Abstract
Background
Since the first report of COVID-19 in 2019, information released has been fast and vast. Health literacy focuses on individual skills to obtain, process, and understand health information and services necessary to make informed health decisions. Increasing the level of health literacy can be addressed by the provision of high-quality, trustworthy, easy-to-access, and easy-to-understand information about COVID-19. This work aimed to assess COVID-19-related health literacy in the Egyptian population living in Alexandria and determine its associated factors. This cross-sectional study was performed during the second wave of the COVID-19 pandemic, using a questionnaire assessing COVID-19-related health literacy, adapted from HLS-EU-Q. The work included four phases. The first phase was questionnaire designing and tools used. The second phase included questionnaire filling by participants. The third phase was concerned with increasing population awareness about the COVID-19 pandemic. The fourth phase was the statistical analysis of the data.

Results
The sample compromised 3960 persons. More than half of the Egyptian population living in Alexandria have inadequate or problematic COVID-19-related health literacy scores. Female gender, younger age, higher socioeconomic status, professions with a medical background, and level of education were positively correlated with COVID-19-related health literacy.

Conclusion
COVID-19-related health literacy levels in the Egyptian population living in Alexandria are not sufficient. Policymakers, healthcare providers, and media must act proactively to increase the level of the citizens’ COVID-19-related health literacy and prepare them for other pandemics that may come later.
Non-hypertrophic gastric outlet obstruction in the paediatric population: a case series with focus on management
Authors: El-Mefleh Naser , Ba’Ath Muhammad Eyad 
Published: December 2023

Abstract
Background
Non-hypertrophic gastric outlet obstruction (GOO) in children is rare and usually presents beyond infancy. Aetiology is variable, and management is not well established due to its rarity.

Methods
We aimed to conduct a descriptive study of these cases within our geographic area. It is a retrospective chart review of all children with non-hypertrophic gastric outlet obstruction presenting to three hospitals in northwest Syria during the period 2019–2023. Demographics, presentation, and management data were extracted.

Results
Twelve cases were identified, eight males, with age range 1–12 years and follow-up range 3–42 months. Eight patients had a history drinking battery acid and one with ingestion of high-dose ibuprofen. The other three had no clear aetiology. Five patients improved by endoscopic balloon dilatations (EBD), and seven needed surgeries. All those who had successful EBD were treated within 3 weeks of ingestion.

Conclusion
Non-hypertrophic GOO in children is rare and mostly related to caustic material ingestion. Treatment by endoscopic balloon dilatation is likely to be successful if done within 3 weeks from caustic ingestion. After that period, often surgery is needed.
CD5 Gene Signature Identifies Diffuse Large B-Cell Lymphomas Sensitive to Brutonʼs Tyrosine Kinase Inhibition
Authors: Cooper Alan , Tumuluru Sravya , Kissick Kyle , Venkataraman Girish , Song Joo Y. , Lytle Andrew , Duns Gerben , Yu Jovian , Kotlov Nikita , Bagaev Aleksander , Hodkinson Brendan , Srinivasan Srimathi , Smith Sonali M. , Scott David W. , Steidl Christian , Godfrey James K. , Kline Justin 
Published: December 2023

PURPOSE A genetic classifier termed LymphGen accurately identifies diffuse large B-cell lymphoma (DLBCL) subtypes vulnerable to Bruton's tyrosine kinase inhibitors (BTKis), but is challenging to implement in the clinic and fails to capture all DLBCLs that benefit from BTKi-based therapy. Here, we developed a novel CD5 gene expression signature as a biomarker of response to BTKi-based therapy in DLBCL. METHODS CD5 immunohistochemistry (IHC) was performed on 404 DLBCLs to identify CD5 IHC+ and CD5 IHC– cases, which were subsequently characterized at the molecular level through mutational and transcriptional analyses. A 60-gene CD5 gene expression signature (CD5sig) was constructed using genes differentially expressed between CD5 IHC+ and CD5 IHC– non–germinal center B-cell-like (non-GCB DLBCL) DLBCLs. This CD5sig was applied to external DLBCL data sets, including pretreatment biopsies from patients enrolled in the PHOENIX study (n = 584) to define the extent to which the CD5sig could identify non-GCB DLBCLs that benefited from the addition of ibrutinib to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). RESULTS CD5 expression was observed in 12% of non-GCB DLBCLs. CD5+ DLBCLs displayed transcriptional features of B-cell receptor (BCR) activation and were enriched for BCR-activating mutations known to correlate with BTKi sensitivity. However, most CD5+ DLBCLs lacked canonical BCR-activating mutations or were LymphGen-unclassifiable (LymphGen-Other). The CD5sig recapitulated these findings in multiple independent data sets, indicating its utility in identifying DLBCLs with genetic and nongenetic bases for BCR dependence. Supporting this notion, CD5sig+ DLBCLs derived a selective survival advantage from the addition of ibrutinib to R-CHOP in the PHOENIX study, independent of LymphGen classification. CONCLUSION CD5sig is a useful biomarker to identify DLBCLs vulnerable to BTKi-based therapies and complements current biomarker approaches by identifying DLBCLs with genetic and nongenetic bases for BTKi sensitivity.
Endothelin signaling in development
Authors: Kanai Stanley M. , Clouthier David E. 
Published: December 2023

ABSTRACT
Since the discovery of endothelin 1 (EDN1) in 1988, the role of endothelin ligands and their receptors in the regulation of blood pressure in normal and disease states has been extensively studied. However, endothelin signaling also plays crucial roles in the development of neural crest cell-derived tissues. Mechanisms of endothelin action during neural crest cell maturation have been deciphered using a variety of in vivo and in vitro approaches, with these studies elucidating the basis of human syndromes involving developmental differences resulting from altered endothelin signaling. In this Review, we describe the endothelin pathway and its functions during the development of neural crest-derived tissues. We also summarize how dysregulated endothelin signaling causes developmental differences and how this knowledge may lead to potential treatments for individuals with gene variants in the endothelin pathway.