bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of Racial Disparities in Cangrelor Therapy in Patients Presenting With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Authors: Abusnina Waiel , Chitturi Kalyan R. , Chaturvedi Abhishek , Lupu Lior , Haberman Dan , Cellamare Matteo , Sawant Vaishnavi , Zhang Cheng , Ben‐Dor Itsik , Satler Lowell F. , Hashim Hayder D. , Case Brian C. , Waksman Ron 
Published: February 2025

ABSTRACTBackgroundCangrelor is an intravenous P2Y12 receptor antagonist that exerts rapid and potent antiplatelet effects. It is associated with a reduction in the indcidence of ischemic events in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).AimsThe aim of our study was to investigate the racial disparities and their impact on outcomes among patients with ACS who were treated with cangrelor during PCI.MethodsWe reviewed the data of patients with ACS who were treated with cangrelor during PCI at our center from 2018 to 2023 and divided between African American (AA) and Caucasian patients. The primary safety outcome was in‐hospital thrombolysis in myocardial infarction (TIMI) major bleeding. The primary efficacy outcome was in‐hospital major adverse cardiac events (MACE), defined as a composite of cardiac death, MI, or stroke. Multivariate regression analysis was performed to assess the primary outcomes after controlling for differences in baseline characteristics.ResultsThe study included 1181 patients who received cangrelor during PCI for ACS, including 616 AA and 565 Caucasian patients. AA patients were significantly younger (61 ± 13 vs. 64 ± 12 years; p < 0.001) and had higher rates of hypertension, diabetes mellitus, and end‐stage renal disease requiring dialysis. There were no significant differences between AA and Caucasian patients regarding in‐hospital TIMI major bleeding (odds ratio [OR]: 0.55; 95% confidence interval [CI]: 0.16–1.88; p = 0.343) and in‐hospital MACE (OR: 1.82; 95% CI: 0.71–4.69; p = 0.212) after controlling for relevant baseline differences.ConclusionNo racial disparities were observed with regard to the administration of cangrelor during PCI in patients presenting with ACS, and cangrelor was not associated with increased bleeding for AA patients as compared to Caucasian patients.
Tailoring P2/P3‐Intergrowth in Manganese‐Based Layered Transition Metal Oxide Positive Electrodes via Sodium Content for Na‐Ion Batteries
Authors: Graff Kincaid , Hou Dewen , Gabriel Eric , Park Jehee , Koisch Alex , Schrock Riley , Conrado Angel , Schwartz Darin , Gutierrez Arturo , Johnson Christopher S. , Lee Eungje , Xiong Hui 
Published: February 2025

AbstractHigh‐manganese content sodium‐ion positive electrodes have received heightened interest as an alternative to contemporary Li‐ion chemistries due to their high abundance, low toxicity, and even geographical distribution. However, these materials typically suffer from poor capacity, unstable cycling performance, and sluggish Na+ kinetics. Herein, we explore a manganese‐based layered transition metal oxide (NaxN0.25Mn0.75O2) and show by X‐ray diffraction (XRD) and high‐angle annular dark‐field scanning transmission electron microscopy (HAADF‐STEM) that careful variation of the sodium content can instigate the formation of a biphasic intergrowth. This intergrown P2/P3 material offered a higher capacity than its monophasic P2 counterpart due to the P3 structure having greater low‐voltage Mn3+/4+ redox. Further, the intergrowth material offers greatly enhanced kinetics and cycling stability when compared to single‐phase P3 material, due to the stabilizing nature of the P2 structure, elucidated by galvanostatic intermittent titration technique (GITT) and operando synchrotron X‐ray diffraction. These results highlight the beneficial effect that the intergrowth structure has on the electrochemical performance of high‐manganese content positive electrode for future sodium‐ion batteries.
The Predictive Value of Circulating Gal‐3 for New Stroke Events in Paroxysmal Atrial Fibrillation Patients Despite Oral Anticoagulation Medications
Authors: Wang Yihan , Luan Qianran , Dong Ying , Zhu Xiaoming 
Published: February 2025

ABSTRACTBackgroundCHA2DS2‐VASc is used to assess the risk of stroke in patients with atrial fibrillation (AF) and guide anticoagulant treatment decisions, but it has limitations in accurately predicting stroke risk in individual patients. The objective of this study is to conduct a cohort study by assessing preoperative levels of Gal‐3 in paroxysmal AF patients, aiming to observe its correlation with the subsequent incidence of stroke events.MethodThis study enrolled 197 patients with nonvalvular paroxysmal AF. Blood samples were taken to test Gal‐3 levels. All patients were followed up for 4 years after admission.ResultsCompared to the nonstroke cases, serum levels of Gal‐3 were markedly elevated in stroke cases (7.08 [IQR, 4.60–10.96] vs. 17.34 [IQR, 8.28–20.31], p < 0.001). Gal‐3 yields a superior AUC (0.748, with a 95%CI of 0.681–0.807) compared to other classical stroke indices, such as BNP, CHA2DS2‐Vas score, and TNI. Remarkably, the Gal‐3 index exhibited a superior predictive capacity, yielding a significant incremental predictive value that surpassed the conventional risk factors (CHA2DS2‐VASc score) for stroke events, as evidenced by an IDI of 16.4% (p < 0.001) and an NRI of 34.7% (p = 0.002).ConclusionThe presence of Gal‐3 is an independent risk factor for stroke in patients with AF. Elevated levels of Gal‐3 have the potential to serve as a valuable biomarker for identifying incident strokes in AF patients. Furthermore, incorporating the assessment of Gal‐3 levels into the conventional CHA2DS2‐VASc score could significantly enhance its predictive accuracy for stroke in AF patients.
Multifunctional Covalent Organic Frameworks for Zinc Metal Anodes
Authors: Hao Zhendong , Li Wenjie , Cao Shihai , Dai Yuming , Cong Yuan , Tao Xuewei , Ju Jia 
Published: February 2025

ABSTRACTAqueous zinc‐ion batteries (AZIBs) are one promising electrochemical energy storage system attributed to their high theoretical capacity, relatively low cost as well as high safety. Nevertheless, the formation for zinc dendrites at the anode side severely impedes their electrochemical performance. Covalent organic frameworks (COFs), as promising porous materials, possess some broad application prospects in advanced energy storage and conversion systems and they have demonstrated their versatility in settling the issues for zinc metal anodes. In this current review, the multifunctionality of COFs is reviewed. The overview toward zinc metal anodes is firstly overviewed. Then, multifunctional covalent organic frameworks toward stable zinc metal anodes is summarized. By construction of nanoporous structure, introduction of negative charges and utilization of zincophilic properties, COFs could act as protective layers for ZIBs. In addition, COFs have been utilized as the anode materials, separators and electrolytes in AZIBs. Finally, some perspective of COFs toward highly stable AZIBs are presented. This review could plat a platform for the application of the porous materials in advanced high‐energy‐density batteries.
DHARANI: A 3D Developing Human‐Brain Atlas Resource to Advance Neuroscience Internationally Integrated Multimodal Imaging and High‐Resolution Histology of the Second Trimester
Authors: Verma Richa , Bota Mihail , Ram Keerthi , Jayakumar Jaikishan , Folkerth Rebecca , Pandurangan Karthika , Ramesh Jivitha Jyothi , Majumder Moitrayee , Raveendran Rakshika , Nanda Reetuparna , K Sivamani , S Amal Dhivahar , Karthik Srinivasa , Kumarasami Ramdayalan , S Suresh , Lata S. , Kumar E. Harish , Rangasami Rajeswaran , Srinivasan Chitra , Kumutha Jayaraman , Vasudevan Sudha , Bhat Koushik , Sam C Chrisline , Neelakantan Sivathanu , Savoia Stephen , Mitra Partha P. , Joseph Jayaraj , Manger Paul R. , Sivaprakasam Mohanasankar 
Published: February 2025

ABSTRACTWe introduce DHARANI, the first online platform with three‐dimensional (3D) histological reconstructions of the developing human brain from 14 to 24 gestational weeks (GW) across the five fetal brains. DHARANI features 5132 Nissl, hematoxylin and eosin stained, 20 µm coronal and sagittal sections, postmortem MRI, and a neuroanatomical atlas with 466 annotated sections covering ∼500 brain structures. It is accessible online at https://brainportal.humanbrain.in/publicview/index.html. The 3D reconstruction enables a volumetric view of the fetal brain, allowing visualization in all three planes akin to MRI, previously unachievable with histological datasets from the fetal brain. This allowed qualitative assessment of the growth of brain regions and layers throughout the second trimester. “DHARANI” documents the initiation of sulci, with the lateral fissure, calcarine, parieto‐occipital, and cingulate sulci, at 14 GW. The central and postcentral sulci appear by 24 GW; however, cytoarchitectonic boundaries become visible before sulcal patterns. Cortical plate (CP) lamination begins at 24 GW in the parietal and occipital cortices. The frontal cortex lacks lamination at 24 GW, although putative Betz cells are already visible and show early patterning in the intermediate zone. The cell‐sparse layer between the CP and subplate, containing late migratory neurons, begins in the orbital cortex at 14 GW and reaches the frontal cortex by 17 GW. The appearance of the honeycomb pattern in the occipital and parietal cortex occurs after 14 GW. Additionally, we describe the development of the thalamic pregeniculate with the rotation of the lateral geniculate nucleus. Cerebellar nuclei and an early Purkinje cell layer appear by 21 GW in the already foliated cerebellar cortex.
Optimizing In Situ Proximity Ligation Assays for Mitochondria, ER, or MERC Markers in Skeletal Muscle Tissue and Cells
Authors: Crabtree Amber , Le Han , Harris Chanel , Oliver Ashton , Barillas Andy , Moore Johnathan , Nguyen Desiree Ngoc‐ha , Rabago Izabella Marie , Rodriguez Benjamin , Stephens Dominique C. , Beasley Heather K. , Garza‐Lopez Edgar , Neikirk Kit , Mungai Margaret , Vang Larry , Vue Zer , Vue Neng , Marshall Andrea G. , Turner Kyrin , Shao Jianqiang , Murray Sandra , Gaddy Jennifer A. , Wanjalla Celestine , Davis Jamaine , Damo Steven , Hinton Antentor O. 
Published: February 2025

AbstractProximity ligation assays (PLAs) use specific antibodies to detect endogenous protein‐protein interactions. PLAs are a highly useful biochemical technique that allow two proteins within proximity to be visualized with fluorescent probes amplified by PCR. While this technique has gained prominence, the use of a PLA in mouse skeletal muscle (SkM) is novel. In this article, we discuss how the PLA method can be used in SkM to study the protein‐protein interactions within mitochondria‐endoplasmic reticulum contact sites (MERCs). © 2025 The Author(s). Current Protocols published by Wiley Periodicals LLC.Basic Protocol: Proximity ligation assay for skeletal muscle tissue and myoblast for MERC proteins
Advantages of ESG Indexes Compared to Traditional Ones in Predicting Stock Prices
Authors: Plastun Alex , Vorontsova Anna , Makarenko Inna , Bilan Yuriy , Khouri Samer , Streimikiene Dalia 
Published: February 2025

ABSTRACTThis paper investigates the predictability of traditional and ESG indices in the Ukrainian stock market, examining potential differences between models. The study tests two hypotheses: (H1) ESG indices exhibit lower predictability than traditional indices, and (H2) different forecasting models should be applied to ESG and conventional indices. Various forecasting models, including AR, ARIMA, ARCH, GARCH, TGARCH, Logit, and Probit regressions, are employed, along with additional tests, using daily data from the Ukrainian stock market (UX, PFTS, and WIG indices) spanning 2015–2022. The findings confirm both hypotheses for the case of returns, indicating less predictability for ESG indices and the need for distinct models. For volatility, there is limited evidence supporting Hypothesis 1, but Hypothesis 2 is confirmed. Possible factors explaining the results include higher information transparency, liquidity, and trading activity in ESG indices. The research has implications for academics and practitioners, emphasizing the importance of employing different models for forecasting ESG and traditional indices. It also highlights the preference for traditional indices in trading and speculative activities. The study suggests that a shift toward ESG indices represents a move toward more efficient markets.
Itinerant curriculum theory: People's theory against the field's epistemicidal ethos
Authors: Paraskeva João M. 
Published: February 2025

AbstractThe field of curriculum studies suffers from a glaring theoretical impasse. Much of this impasse has been rightly attributed to the triumphalism of the neoliberal wave that has massacred the educational hemisphere with policies and practices that reduce pedagogy to an instrumentalist praxis directly associated with the thirsty desires and needs of the market. However, another substantive part of this impasse – and not much explored in our scholarly affairs – relates to the apparent breakdown of many critical and post‐critical approaches. The combination of these two axes – completely antagonistic – has contributed to the consolidation of the epistemicidal nature of the curriculum. At the core of this article is a clarion call for all the scholars in the field to counter such an impasse, deterritorializing their approaches and commit to an itinerant position to address the world's endlessly different and diverse epistemological traditions, disestablishing the eugenic nature of our field – its theory and development. The article also explores significant drawbacks faced by counter‐hegemonic impulses in our field. In doing so, this article unveils the challenges of building a hegemonic critical pedagogical platform. It develops a laudatory eulogy for a collective engagement with an itinerant curriculum theory (ICT) as a just people's theory towards social and cognitive justice.
Development and Validity of the Adult Reading History Questionnaire (ARHQ) for Chinese
Authors: He Yuxiao , Tang Jiuqing , Yang Xinyan , Song Zujun , Ding Ning , Jia Yao , Liu Li , Zhao Jingjing 
Published: February 2025

ABSTRACTThe Adult Reading History Questionnaire (ARHQ) is a popular instrument for screening dyslexia in adults. Yet, there is no evidence suggesting its applicability in Chinese. The present study aims to develop a Chinese Adult Reading History Questionnaire (Chinese‐ARHQ) and to assess its validity among Chinese adults. A total of 2439 Chinese adults completed the questionnaire of Chinese‐ARHQ with 2234 questionnaires valid for further analysis (Nmales = 825, Mage = 26.29 years, SDage = 9.12). Among these participants, 184 completed the questionnaire twice and 221 completed reading‐related tests. Results showed that the Chinese‐ARHQ had good internal consistency reliability (Cronbach's α = 0.88), and the test–retest reliability was 0.81. Three factors (current reading, dyslexia symptoms and memory) were extracted through exploratory factor analysis. The scores of Chinese‐ARHQ and its factors were both related to reading and phonological skills, revealing the good criterion validity of the questionnaire. Receiver operating characteristic (ROC) analysis revealed that the optimal threshold for the Chinese‐ARHQ was 0.36 with a sensitivity of 83.3% and a specificity of 75.9%. Additionally, adults screened by the Chinese‐ARHQ (> 0.36) performed worse in reading and phonological awareness, further validating the Chinese‐ARHQ as a reliable screening tool for Chinese dyslexia in adults.
Bacterial Community Structure in Soils With Fire‐Deposited Charcoal Under Rotational Shifting Cultivation of Upland Rice in Northern Thailand
Authors: Arunrat Noppol , Uttarotai Toungporn , Kongsurakan Praeploy , Sereenonchai Sukanya , Hatano Ryusuke 
Published: February 2025

ABSTRACTRotational shifting cultivation (RSC) is a traditional agricultural practice in mountainous areas that uses fire to clear land after cutting vegetation for cultivation. However, few studies have assessed the effect of fire‐deposited charcoal on the diversity and composition of soil microbial communities, and none have been conducted in Thailand. Therefore, this study was conducted 1 year after a fire in an abandoned 12‐year RSC in Chiang Mai Province, northern Thailand. Charcoal samples were collected from the surface litter layer, while charcoal‐soil mixtures were taken from the surface soil (0–2 cm). Soil samples from 2 to 7 cm captured the charcoal‐soluble layer, and samples from 7 to 15 cm represented soil without charcoal incorporation. The results revealed that charcoal led to higher pH and electrical conductivity in the charcoal layer, with notable differences in soil texture across layers, including the highest sand and silt content in the charcoal‐mixed soil layer (0–2 cm). Soil organic matter and total nitrogen were significantly higher in the charcoal‐mixed layer compared to deeper layers, indicating improved nutrient retention due to charcoal presence. Enhanced microbial diversity was observed in the charcoal and charcoal‐mixed soil layers, with Proteobacteria, Chloroflexi, and Planctomycetota dominating across all soil samples. The bacterial genus Ilumatobacter exhibited significant changes in abundance in the charcoal layer. Additionally, Pseudolabrys was more abundant in charcoal‐leached soil, while JG30a‐KF‐32 showed greater abundance in soil without charcoal. Shifts in Proteobacteria and Planctomycetota abundance were evident in the charcoal leaching and non‐charcoal layers. Network analysis indicated more complex bacterial interactions in the charcoal‐mixed soil layer, with reduced network complexity observed in the charcoal leaching layer and the layer without charcoal. These findings imply that charcoal provides a favorable environment for diverse and interactive bacterial communities, potentially benefiting soil health and fertility recovery in RSC fields.
A centurial signature of anthropogenic nitrogen and carbon in California serpentine ecosystems
Authors: McLaughlin Blair C. , Vallano Dena M. , Garcia Jeff , Koch Paul L. , Morozumi Connor N. , Polissar Pratigya J. , Zilliacus Kelly M. , Zavaleta Erika S. 
Published: February 2025

AbstractIncreasing anthropogenic emissions of nitrogen (N) and carbon (C) are major threats to ecosystems globally. Although atmospheric N deposition is likely affecting N cycling and community composition in California's serpentine ecosystems, a historical record of N inputs to vegetation has yet to be reconstructed for these nutrient‐limited biodiversity hotspots. For leather oak (Quercus durata var. durata), a foundational, serpentine‐endemic species, we investigated leaf N and C isotopic composition (δ15N and δ13C) and leaf %N of herbarium and modern leaf samples collected from 1899 to 2009 from serpentine ecosystems in two study areas in California: Santa Clara County, and Lake and Napa Counties combined. We also evaluated tree ring growth over a similar time period in long‐lived leather oak individuals. Leaf δ15N and δ13C values decreased over time in both study areas, likely reflecting changes in the regional and local atmospheric N and C pools caused by human perturbation. However, leaf %N values and stem growth did not change over time with increasing N deposition, indicating that increasing atmospheric N deposition and CO2 concentration may not translate to increased N uptake or productivity in plants with conservative growth strategies, even in ecosystems thought to be N‐limited. In serpentine systems, this could competitively advantage nitrophilic invasive annual grasses and accelerate trends toward native species loss. While the rates of decline in leaf δ15N values were similar between study areas, rates of decline in leaf δ13C values were steeper in Santa Clara County, possibly reflecting its more urban environment. Herbarium samples combined with tree ring data can provide a valuable opportunity to explore the historical record of human‐induced changes in N and C cycling and their biotic impacts.
eDNA Sampling Systems for Salmon Ecosystem Monitoring
Authors: Deeg Christoph M. , Saunders Robert G. , Tam Christopher , Kaukinen Karia , Li Shaorong , Bass Arthur L. ,   Uu‐a‐thluk Fisheries, Miller Kristina M. 
Published: February 2025

ABSTRACTEnvironmental DNA (eDNA) is transforming the way aquatic ecosystems are monitored and managed by scientists, resource managers, ENGOs, First Nations communities, and citizen scientists alike. However, available sampling systems currently don't allow for combined high filtration volumes, rapid sample collection, and preservation in the field, thus far hindering broad scale eDNA studies in the ocean specifically for small and medium scale organizations. To overcome these challenges, several modular water sampling systems that utilize hollow‐membrane (HM) filtration cartridges were developed by RKS laboratories and tested by the Fisheries and Oceans, Canada, Molecular Genetics Laboratory. Compared to Sterivex filters, an industry standard for eDNA filtration, the HM filtration cartridges allowed for a six‐fold increase in filtration volume and threefold increase in filtration speed. The field sampling systems, which combine pumps, a programmable controller, an air pump, an ozone generator, and up to eight filters at once, enabled efficient direct eDNA filtration from diverse aquatic environments, from creeks to the open ocean. To evaluate ease of deployment, we present the results of a 3 day workshop where technical staff of an Indigenous resource management organization, without any prior knowledge in eDNA sampling, were trained and performed independent eDNA sample collection. The samples were analyzed by metabarcoding and qPCR to reveal the distributions of salmon and other species co‐occurring in salmon ecosystems, from large ephemeral predators, to the planktonic prey of salmon, even including their pathogens. In this example study, we further observed a substantial shift in community composition in the vicinity of aquaculture facilities where marine species associated with aquaculture feed were detected in freshwater at high relative abundance. This study demonstrates how these sampling systems provide an efficient entry point for small and medium scale organizations to utilize eDNA to fulfill their research and monitoring objectives.
Amino Acid‐Mediated Enantioselective Synthesis of a Bicyclic Ketocarbaldehyde: Theoretical and Experimental Insights into a Key Intermediate for Some Polycyclic Diterpene Synthesis
Authors: Leonelli Francesca , Vetica Fabrizio , Bodo Enrico , Russo Stefano , Michelini Lorenzo , Sturabotti Elisa , Mazzoccanti Giulia , Ciogli Alessia , Demitri Nicola , Lamba Doriano , Masi Annalisa , Migneco Luisa Maria , Bettolo Rinaldo Marini 
Published: February 2025

AbstractA study on the amino acid‐mediated intramolecular cyclization of diketoaldehyde 2 to form bicyclic ketocarbaldehyde 1, a potentially useful intermediate in the synthesis of some polycyclic diterpenes, is hereafter presented. This cyclization exhibits a peculiar enantio‐selectivity if compared to similar intramolecular cyclizations due to its product being the (S)‐enantiomer when using d‐amino acids. Our findings reveal that the transformation proceeds through two irreversible steps: the cyclization and the subsequent dehydration process. The reaction enantiomeric excess (e.e.) was optimized by systematically varying the amino acids, solvents, and acids used. Aldol intermediates were successfully isolated. The structure of the most abundant one was confirmed by X‐ray analysis, which supported the proposed reaction mechanism. NMR and MS were employed to monitor in real‐time the formation and the evolution of these intermediates. This approach allowed us to detect the key species that contribute to the enantioselectivity and yield of the final product. Additionally, the transition state energies associated with the formation of the eight possible aldol intermediates were examined through computational studies, further elucidating the mechanistic pathway of this enantioselective cyclization.