bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of clonal evolution identified by sequential FISH in untreated chronic lymphocytic leukaemia
Authors: Dondolin Riccardo , Bellia Matteo , Rasi Silvia , Deambrogi Clara , Talotta Donatella , Mouhssine Samir , Al Essa Wael , Mahmoud Abdurraouf Mokhtar , Faraci Danilo , Gaidano Gianluca , Moia Riccardo 
Published: January 2024

Aim: The aim of the current study was to evaluate the potential clinical impact of clonal evolution detected by fluorescence in situ hybridization (FISH) in untreated chronic lymphocytic leukaemia (CLL) patients managed with a watch-and-wait strategy.
Methods: We performed both overall survival (OS) and time to first treatment (TTFT) analysis. For the first one, we exploited a real-life cohort of 123 consecutive CLL patients followed at our institution, for which at least a second FISH evaluation during watch and wait was available. For TTFT analysis, we considered only patients treated after the second FISH sample (n = 69).
Results: Considering the original cohort, patients who acquired a FISH abnormality displayed a worse outcome with a median OS of 91.9 months compared to 147.3 months for patients who did not acquire any FISH abnormalities (P = 0.007). Unmutated immunoglobulin heavy chain gene (IGHV) genes were associated with a higher probability of acquiring a FISH abnormality (P = 0.04). Turning to TTFT analysis, patients who gained at least one FISH abnormality (n = 7, 10%) were characterised by an earlier treatment requirement with a median TTFT of 1.1 months, compared to 2.7 months in patients who did not acquire any FISH abnormalities (n = 62, 90%) (P = 0.025).
Conclusions: The dynamic acquisition of karyotypic abnormalities by FISH predicts poor outcomes and early treatment requirement in CLL patients. Our results suggest that FISH analysis could be integrated with other clinical and biological features to obtain dynamic scores that are able to predict outcomes at different phases of disease history.
Cash Holding em Governos Locais Brasileiros
Authors: Cabello Otavio Gomes , Rocha de Azevedo Ricardo , Dario Capitani Daniel Henrique 
Published: January 2024

Objetivo da pesquisa - A pesquisa teve como objetivo examinar os determinantes de retenção de caixa dos governos locais brasileiros.
Enquadramento teórico – Este trabalho se apoia na teoria de finanças da preferência pela liquidez.
Metodologia – trata-se de pesquisa econométrica desenvolvida com dados econômico-financeiros dos anos de 2017 a 2021 dos municípios brasileiros, utilizando o modelo de regressão linear com dados em painel, efeitos fixos.
Resultados - Os resultados apresentaram que as variações de despesa com pessoal e encargos, imprecisão da previsão das receitas correntes, dependência de receitas e população configuram como determinantes de cash holding em governos locais brasileiros.
Originalidade – Os resultados preenchem uma lacuna existente na literatura de finanças públicas sobre quais seriam os determinantes de retenção de caixa dos governos locais brasileiros.
Contribuições teóricas e práticas - Os resultados contribuem para uma discussão sobre políticas de retenção de caixa nos governos de países emergentes e contribuem com a literatura que discute o efeito flypaper, dado que o efeito pode ocorrer em exercícios seguintes ao ingresso da receita, não tratado pela literatura. Por fim, a pesquisa apresenta a imprecisão da previsão das receitas correntes como um novo determinante de cash holding nos governos locais.
Media Buku Saku Bermuatan Keunggulan Seni Tari Lokal Kabupaten Pacitan untuk Meningkatkan Apresiasi Budaya pada Siswa SD
Authors: Saputra Muhammad Aji , Ardhyantama Vit , Tisngati Urip 
Published: January 2024

Penelitian ini bertujuan untuk mendeskirpisikan: (1) prosedur pengembangan media buku saku; (2) kelayakan pengembangan media buku saku; (3) hasil pengembangan media buku saku untuk meningkatkan apresiasi budaya siswa. Jenis penelitian ini research and development (R&D) dengan model pengembangan 4D. Teknik pengumpulan data dengan menggunakan observasi, wawancara, angket, dan dokumentasi. Analisis data menggunkan teknik tingkat kevalidan produk dan analisis data uji coba. Hasil penelitian menunjukan bahwa: (1) media buku saku untuk meningkatkan apresiasi budaya siswa telah dikembangkan dengan model pengembangan 4D dengan uji coba dan validasi ahli; (2) Media buku saku layak berdasarkan penilaian ahli materi dengan rata-rata sekor 4 “Valid”, penilaian ahli media dengan rata-rata skor 4,11“Vaild”, penilaian ahli bahasa dengan rata-rata skor 3 ‘‘ Cukup Valid’’, dan penilaian siswa dalam uji kelompok kecil dengan rata-rata 4 “Valid” (3) media dinyatakan efektif berdasarkan pencampaian aperesiasi budaya siswa yang mencapai nilai sebesar 100%.
State-dependent auditory-reward brain network connectivity predicts degree of pleasure to music
Authors: Mori Kazuma , Zatorre Robert 
Published: January 2024

Abstract
Music can evoke pleasurable and rewarding experiences. Past studies that examined task-related brain activity revealed individual differences in musical reward sensitivity traits, and linked them to interactions between the auditory and reward systems. However, state-dependent fluctuations in spontaneous neural activity in relation to music-driven rewarding experiences have not been studied. Here, we used functional MRI (N=49) to examine whether the coupling of auditory-reward networks during a silent period immediately before music listening can predict the degree of musical rewarding experience. We used machine learning models and showed that the functional connectivity between auditory and reward networks, but not others, could robustly predict subjective, physiological, and neurobiological aspects of the strong musical reward of chills. Specifically, the right auditory cortex-striatum/orbitofrontal connections predicted the reported duration of chills and the activation level of NAcc and insula, whereas the auditory-amygdala connection was associated with psychophysiological arousal. Furthermore, the predictive model derived from the first sample of individuals was generalized in an independent dataset using different music samples. The current study reveals the critical role of sensory-reward connectivity in pre-task brain state in modulating subsequent rewarding experience.
Investigation of the effective parameters on Al6061 / Al 2 O 3 .WC.SiC composite fabricated by friction stir process
Authors: Delivand Mohammad Hasan Rajabi , Lashgari Hossein , Hosseinpour Mohammad , Momeni Amir , Parvizi Soroush 
Published: January 2024

Abstract
Friction Stir processing is an emerging technique that can be utilized to modify the microstructure and mechanical properties of materials, thereby serving as an effective method for fabricating surface composites. This investigation employed the earlier process to produce a surface composite of 6061AA alloy integrated with Al203, WC, and SiC reinforcement particles, each with an average particle size of 10 ± 4 µm. Initially, linear and rotational speeds were implemented on the specimens. Subsequently, the optimal model was selected based on the microstructure outcomes and the highest microhardness value. As a result, the optimal sample was determined to have a rotational speed of 1000 rpm and a linear velocity of 40 mm/min and underwent four passes. A thorough examination of the microstructure of the produced surface composite was conducted through optical microscopy. Furthermore, the mechanical and microstructural properties between the manufactured composite and the base metal were compared comprehensively. The outcomes of the microhardness test revealed a significant improvement in the composite sample compared to the base metal. Specifically, the base metal exhibited a Vickers hardness value of 44, while the four-pass processed specimens displayed 61. The tests above determined that the samples processed at a rotational speed to linear ratio 25 demonstrated acceptable surface quality.
From peanut shell to 2, 5-dimethylfuran: the role of Zr-micro/mesoporous zeolites
Authors: Bonetto Luciana , Fermanelli Carla , Saux Clara 
Published: January 2024

Abstract
Catalytic pyrolysis of biomass is a promising process for the conversion of agricultural residues into renewable bio-oils, wherein zeolites play a key role in their upgrading. In this work, peanut shell pyrolysis was catalysed by micro/mesoporous ZSM-11 zeolites modified by the incorporation of zirconium. Mesopores were generated in the microporous zeolitic structure by post synthesis alkaline treatment using potassium hydroxide as basic medium. The effect of this treatment and its parameters were studied in detail. The obtained materials were extensively characterized. Results showed that micro/mesoporous ZSM-11 zeolites maintained their crystalline structure after the desilication process and presented excellent textural properties, such as high BET surface. Zirconium incorporation increased the amount of Lewis and Brønsted acid sites. Pyrolysis tests in presence of this material remarkably increased the selectivity to 2,5-dimethylfuran (DMF), a potential biofuel with high energy density, among other high value products for the chemical industry. Therefore, micro/mesoporous zeolite modified with Zr is presented as an excellent catalyst for pyrolysis of agricultural wastes.
Examining the photocatalytic and antioxidant properties of tripled doped Co-Ni-Zn TiO2 nanoparticles: A new class of nanocatalyst synthesized by chemically and biologically approach using microwave-assisted method
Authors: Thakur Nikesh , Thakur Naveen 
Published: January 2024

Abstract
Water pollution encompasses the contamination of water bodies resulting from the discharge of industrial dyes that contains array of harmful substances and requires necessitates treatment to render the water safe for various reuse purposes. This study focuses on chemically and biologically synthesized tripled doped Co-Ni-Zn TiO2 NPs, a novel photocatalyst for removal of dyes. Synthesized NPs contained tetragonal anatase phase of TiO2, according to XRD and Raman analyses. SEM-EDS confirmed the morphology and chemical composition of synthesized NPs. TEM revealed spherical NPs in both chemically and biologically synthesized NPs, in size from 21 to 33 nm. The ability of synthesized NPs to act as photocatalyst for the degradation of polluting dyes: congo red (CR), methyl orange (MO), methylene blue (MB) and rhodamine B (RhB) was examined. Also, nitric oxide (NO), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (HP) free radical tests were used to test the antioxidant capabilities of synthesized NPs.
Comparison of pregnancy outcomes between 4th day morula and 5th day blastocyst after embryo transfer:a retrospective cohort study
Authors: Sun Yiqun , Shen Qi , Xi Haitao , Sui Liucai , Fu Yanghua , Zhao Junzhao 
Published: January 2024

Abstract
Background
This study was designed to evaluate pregnancy outcomes between morulae transferred on day 4 (D4) and blastocysts transferred on day 5 (D5).
Methods
From September 2017 to September 2020, 1963 fresh transfer cycles that underwent early follicular phase extra-long protocol for assisted conception in our fertility center were divided into D4 (324 cases) and D5 (1639 cases) groups based on the number of days of in vitro culture after fertilization, and the general basic information, clinical and embryonic conditions of patients in both groups were compared. To compare the differences in pregnancy outcomes, the D4 and D5 groups were further divided into groups A and B based on single and double embryo transfer.
Results
In single embryo transfer, there was no significant difference between groups D4A and D5A (P > 0.05). In double embryo transfer, group D4B had a lower newborn birthweight and a larger proportion of low birthweight infants (P < 0.05). The preterm delivery rate, twin delivery rate, cesarean delivery rate, and percentage of low birthweight infants were lower in the D5A group than in the D5B group (P < 0.05).
Conclusion
When factors such as working life and hospital holidays are being considered, D4 morula transfer may be a good alternative to D5 blastocyst transfer. Given the in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI) success rate and risk of twin pregnancy, D4 morula transfer requires an adapted decision between single and double embryo transfer, although a single blastocyst transfer is recommended for the D5 transfer in order to decrease the twin pregnancy rate.
Time to diagnosis and determinants of diagnosis delays of people living with a rare disease: a Rare Barometer retrospective patient survey
Authors: Dubief Jessie , Faye Fatoumata , Crocione Claudia , de Peña Roberta Anido , Bellagambi Simona , Peñaloza Luciana Escati , Hunter Amy , Jensen Lene , Oosterwijk Cor , Schoeters Eva , de Vicente Daniel , Faivre Laurence , Wilbur Michael , Cam Yann Le 
Published: January 2024

Abstract

Timely diagnosis is one of the most serious challenges faced by people living with a rare disease (PLWRD), and this new research estimates that in Europe, the average Total Diagnosis Time (TDT) is 4 to 5 years. We investigated the duration of the TDT for PLWRD in Europe, the difficulties associated with their diagnosis odyssey and the main determinants of diagnosis delays for all rare diseases (RD). We conducted a survey of PLWRD and their families between March and June 2022 using Rare Barometer, the survey initiative of EURORDIS-Rare Diseases Europe. In geographical Europe, we surveyed 6,507 people living with 1,675 RD in 41 countries. We then peformed a descriptive analysis and ordinal logistic regressions to identify the main determinants of diagnosis delays. Average TDT is 4.7 years. 56% of respondents were diagnosed more than 6 months after a first medical contact. The main determinants of diagnosis delays are symptom onset before 30 years of age, especially during childhood (OR = 3.11; 95% CI: 2.4-4.0) and adolescence (OR = 4.79; 95% CI: 3.7–6.2), being a woman (OR = 1.22; 95% CI:1.1–1.4), living in Northern Europe (OR = 2.15; 95% CI:1.8–2.6) or Western Europe (OR = 1.96; 95% CI:1.6–2.3), the number of healthcare professionals consulted (OR = 5.15; 95% CI:4.1–6.4), misdiagnosis (OR = 2.48; 95% CI:2.1–2.9), referral to a centre of expertise (OR = 1.17; 95% CI:1.0-1.3), unmet needs for psychological support (OR = 1.34; 95% CI:1.2–1.5) and financial support (OR = 1.16; 95% CI:1.0-1.3), having a genetic disease (OR = 1.33; 95% CI:1.1–1.5) and a family history of a RD (OR = 1.36; 95% CI:1.1–1.6). These determinants can inform policies and actions to improve access to diagnosis for all PLWRD.
Real-Time CUDA Implementation of High-Order Vertical Synchrosqueezing
Authors: Gambrych Jacek , Abratkiewicz Karol 
Published: January 2024

Abstract

Fast and efficient implementations of Fourier’s analysis techniques for non-stationary signals have been desired recently, not only in civilian but also in military applications. The ability to work in a real-time regime with high dependability and reliability when wideband signals are processed is a challenging but highly desirable task (e.g. analysis of radar signals). This article delves into the real-time implementations of two variants of vertical synchrosqueezing (VSS). The ability to achieve real-time processing was enabled by leveraging Nvidia CUDA technology. Validation through real-life radar signal processing scenarios has confirmed the accuracy and efficiency of the proposed algorithms. To the authors’ knowledge, this is the first real-time implementation of VSS given in the literature.
Healthy Eating and Active Lifestyle after Bowel Cancer (HEAL ABC) – Feasibility Randomised Controlled Trial
Authors: Sremanak Jana , Sowerbutts Anne Marie , Todd Chris , Cooke Richard , Pearce Lyndsay , Leiberman David , Mclaughlin John , Hil Jim , Ashby Helen , Ramesh Aswatha , Burden Sorrel 
Published: January 2024

Abstract

Background: Evidence from cohort studies indicates that a healthy lifestyle can improve cancer survival but evidence from randomised controlled trials (RCT) is lacking. Thus, this study tested the feasibility of conducting a lifestyle intervention in patients after colorectal cancer (CRC) treatment.

Methods: An intervention was developed based on World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) recommendations, the Health Action Process Approach and Motivational Interviewing and tested using a feasibility/mixed-methods RCT. Participants were allocated to a three-month telephone-based intervention with printed resources and website versus standard care control group. The follow up period was six months. Data on anthropometry, diet, physical activity were collected and analysed using Stata (V14, StataCorp LLC).

Results: In total, 34/35 participants completed the intervention, and 31 (89%) completed follow up. Recruitment was challenging (31 ineligible, 37 declined). There was improvement in WCRF/AICR score in the intervention group compared to control at three months (R2 1.1, 95%CI 0.5;1.6, p=0.0001), and at six months (R2 0.9, 95%CI 0.1;1.7, p=0.03), and in Diet Quality Index-International score (R2 8.9, 95%CI 3.3;14.5, p=0.003) at three months, and at six months (R2 8.2, 95%CI 1.1;15.3, p=0.02). Following WCRF/AICR recommendations led to a 10% reduction in ultra-processed food consumption in the intervention group.

Conclusions: The intervention was feasible for 87% of intervention participants, supporting them in healthy lifestyle changes. However, alternative recruitment strategies are needed to provide a large enough sample for a powered RCT to determine the efficacy of the intervention.
Using a Smartwatch and Smartphone to Assess Early Parkinson’s Disease in the WATCH-PD Study – 12-month results
Authors: Adams Jamie , Kangarloo Tairmae , Gong Yishu , Khachadourian Vahe , Tracey Brian , Volfson Dmitri , Latzman Robert , Cosman Josh , Edgerton Jeremy , Anderson David , Best Allen , Kostrzebski Melissa , Auinger Peggy , Wilmot Peter , Pohlson Yvonne , Jensen-Roberts Stella , Mueller Martijn , Stephenson Diane , Dorsey Ray 
Published: January 2024

Abstract

Digital measures may provide objective, sensitive, real-world measures of disease progression in Parkinson’s disease (PD). However, multi-center longitudinal assessments of such measures are few.
We recently demonstrated that baseline assessments of gait, tremor, finger tapping, and speech from a commercially available smartwatch, smartphone, and research-grade wearable sensors differed significantly between 82 individuals with early, untreated PD and 50 age-matched controls. Here, we evaluated the longitudinal change in these assessments over 12 months in a multi-center observational study using a generalized additive model, which permitted flexible modeling of at-home data. All measurements were included until participants started medications for PD.
Over one year, individuals with early PD experienced significant declines in several measures of gait, an increase in the proportion of day with tremor, modest changes in speech, and few changes in psychomotor function. As measured by the smartwatch, the average (SD) arm swing in clinic decreased from 25.9 (15.4) degrees at baseline to 19.9 degrees (13.7) at month 12 (p=0.004). The proportion of awake time an individual with early PD had tremor increased from 19.3% (18.0%) to 25.6% (21.4%; p<0.001). Activity, as measured by the number of steps taken per day, decreased from 3052 (1306) steps per day to 2331 (2010; p=0.16), but this analysis was restricted to 10 participants due to exclusion of those that had started PD medications and lost data.
The change of these digital measures over 12 months was generally larger than corresponding change in individual items on the Movement Disorder Society—Unified Parkinson’s Disease Rating Scale but not greater than the change in the overall scale. Successful implementation of digital measures in future clinical trials will require improvements in study conduct, especially data capture. Nonetheless, gait and tremor measures derived from a commercially available smartwatch and smartphone hold promise for assessing the efficacy of therapeutics in early PD.
Simulation of Groundwater Dissolved Organic Carbon in Yufu River Basin during Artificial Recharge: Improving the SWAT-MODFLOW-RT3D Reaction Module
Authors: Hong Xiaotao , Zhang Wenjing , Wang Zezheng , Shi Chao , Chen Xuequn , Liu Dan , Li Shuxin , Huan Huan 
Published: January 2024

Abstract
To maintain the spring water supply and groundwater level, the Chinese government has adopted a series of water regulation measures in Jinan. However, as a result of water exchange, considerable volumes of dissolved organic carbon (DOC) can reach groundwater. Changes in DOC concentrations in groundwater can affect the physical and chemical stability of groundwater, thereby altering the subsurface microecological environment. In addition, the Chinese government's targets for carbon peaking and carbon neutrality have posed new challenges to the Yufu River watershed's ability to maintain and enhance its carbon sinks and storage capacity. This study aimed to develop a SWAT-MODFLOW-RT3D model specifically designed for the Yufu River watershed, with the purpose of simulating variations in DOC concentration in groundwater under diverse artificial recharge scenarios. The ultimate objective was to offer valuable insights into the effective management of water resources in the designated study region. The modified SWAT-MODFLOW-RT3D model simulated the variations of DOC concentration in groundwater under three artificial recharges scenarios, which are (a) Recharged by Yellow River water; (b) Recharged by Yangtze River water; (c) Recharged by Yangtze River and Yellow River water. The study revealed that the distribution of DOC concentration in groundwater within the watershed exhibited notable spatial variations as a result of the impact of surface water infiltration recharge. The concentration of DOC in groundwater exhibits an increase in proximity to the river, whereas it remains relatively constant in other regions within the watershed. Additionally, as artificial recharge periods increase, the impact of rivers on groundwater DOC concentrations grows steadily stronger. The primary cause of the ongoing rise in groundwater DOC concentration in the watershed is the long-term storage of water resources. By 2030, the maximum level of DOC in the basin will exceed 6.20 mg/l. The Yellow River water recharge scenario offers greater groundwater recharge and the lowest DOC input unit volume in the research area when compared to the Yangtze River water and combined water resources recharge scenarios. Lithology is also a key factor that determines how the model performs in the end. The primary source of DOC recharge in groundwater is lateral recharge from rivers, not precipitation infiltration. The findings of this study indicate that, particularly when recharge water supplies are enhanced with organic carbon, DOC concentrations in groundwater may alter dramatically during artificial storage. In order to lessen the detrimental effects of water backfilling on groundwater quality, this coupled modeling analysis is crucial.