bluuebunny/crossref_metadata_2025_split huggingface dataset:
CKD-EPI and EKFC GFR Estimating Equations: Performance and Other Considerations for Selecting Equations for Implementation in Adults
Authors: Inker Lesley A. , Tighiouart Hocine , Adingwupu Ogechi M. , Shlipak Michael G. , Doria Alessandro , Estrella Michelle M. , Froissart Marc , Gudnason Vilmundur , Grubb Anders , Kalil Roberto , Mauer Michael , Rossing Peter , Seegmiller Jesse , Coresh Josef , Levey Andrew S. 
Published: October 2023

Significance Statement
New eGFR equations from Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and European Kidney Function Consortium (EKFC) using creatinine (eGFRcr), cystatin C (eGFRcys), and both (eGFRcr-cys) have sufficient accuracy for use in clinical practice, leading to uncertainty in selecting equations for implementation. The authors evaluated performance of equations in an independent population of 4050 adults and evaluated other considerations important for implementation. They found that CKD-EPI and EKFC equations are approaching convergence, with better performance of eGFRcr-cys equations in the overall group and fewer differences among race, sex, and age subgroups than eGFRcr equations. Larger differences among eGFRcr equations reflect regional population differences in creatinine, forcing a trade-off between accuracy and uniformity in global implementation of eGFRcr equations. More widespread use of cystatin C could avoid this trade-off.

Background
New CKD-EPI and EKFC eGFR equations using eGFRcr, eGFRcys, and both (eGFRcr-cys) have sufficient accuracy for use in clinical practice. A better understanding of the equations, including their performance in race, sex and age subgroups, is important for selection of eGFR equations for global implementation.

Methods
We evaluated performance (bias and P30) of equations and methods used for equation development in an independent study population comprising 4050 adults pooled from 12 studies. The mean (SD) measured GFR was 76.4 (29.6) ml/min per 1.73 m2 and age 57.0 (17.4) years, with 1557 (38%) women and 579 (14%) Black participants.

Results
Coefficients for creatinine, cystatin C, age, and sex in the CKD-EPI and EKFC equations are similar. Performance of the eGFRcr-cys equations in the overall population (bias <±5 ml/min per 1.73 m2 and P30 >90%) was better than the eGFRcr or eGFRcys equations, with fewer differences among race, sex, and age subgroups. Differences in performance across subgroups reflected differences in diversity of source populations and use of variables for race and sex for equation development. Larger differences among eGFRcr equations reflected regional population differences in non-GFR determinants of creatinine.

Conclusion
CKD-EPI and EKFC equations are approaching convergence. It is not possible to maximize both accuracy and uniformity in selecting one of the currently available eGFRcr equations for implementation across regions. Decisions should consider methods for equation development in addition to performance. Wider use of cystatin C with creatinine could maximize both accuracy and uniformity of GFR estimation using currently available equations.
Micosis fungoide estadio III, enfermedad eritrodérmica: reporte de caso
Authors: Ruilova González Lizbet Yolanda , Vázquez Gárate María Gracia , Feijó Erazo Joseph Mateo 
Published: October 2023

Introducción: la micosis fungoide (MF) es el linfoma cutáneo más común que se produce por una proliferación monoclonal de linfocitos T malignos cuyo órgano blanco primario es la piel; es más frecuente en el sexo masculino y en mayores de 50 años, siendo raro en jóvenes. El curso clínico en la piel es insidioso, las lesiones parten de una erupción macular eritematosa con descamación a máculas, placas, tumores y eritrodermia pudiendo afectar a gran parte de la superficie cutánea.
Caso clínico: paciente de 25 años, que presenta inicialmente una lesión cutánea eritematosa, seca y descamativa en la cara anterior de muslo de 2 cm, con periodos de exacerbación y remisión, evoluciona hasta comprometer el 80% de la superficie corporal respetando únicamente la cara, cuello y pliegues axilares e inguinales, se realizó biopsia con diagnóstico de micosis fungoide. Tratado con antimetabolitos, modificadores de la respuesta inmunológica, ácido fólico, antibióticos y analgésicos, presentando una evolución favorable.
Conclusiones: la micosis fungoide puede presentarse en jóvenes como en el paciente a los 13 años con lesiones dérmicas, la demora en el diagnóstico ocasionó un compromiso que alcanzó hasta 80% de la superficie corporal, diagnosticándose de etapa T4NXM0 B0, estadio clínico III luego de terapia específica obtuvo respuesta y evolución favorable.
El equipo de neurodesarrollo en la sospecha clínica del Síndrome de Williams (SW): reporte de caso.
Authors: Huiracocha Tutiven María de Lourdes , Newell Glen , Marín Cordero Andrea Estefanía , Bermeo Serrano Jéssica Dayanna , Calderón Siguencia Mariela Cecilia , Espinoza Alcalá Kwan Yin Estefanía , Mogrovejo Barros Mónica Marlene , Campoverde Vizhñay Johanna Lucía 
Published: October 2023

Introducción: en la ruta diagnóstica de los niños con Retraso Global del Desarrollo (RGD) se encuentra la identificación de malformaciones y la derivación a especialistas para la determinación del síndrome genético que oriente la intervención y el pronóstico.
Caso clínico: niño de 5 años de edad diagnosticado por el equipo de neurodesarrollo (pediatra, estimuladora temprana, fonoaudióloga, fisioterapeuta) de RGD por presentar problemas de atención, alteración neurológica, selectividad alimentaria, disfagia orofaríngea. Además, por delgadez severa, características faciales, estenosis supravalvular aórtica severa con hipoplasia de arco aórtico se considera alta sospecha de Síndrome de Williams (SW), se solicitó examen confirmatorio, el test de FISH, mismo que no se realiza por limitaciones en la cartera de servicios del Estado ecuatoriano. Plan terapéutico: tratamiento cardiológico; plan de intervención en neurodesarrollo: estímulo de actividades de la vida diaria, mejora de las habilidades de comunicación, introducción de alimentos nuevos en texturas y sabores, optimización de la independencia en la movilización, fortalecimiento de las competencias parentales y evaluaciones periódicas.
Conclusiones: la participación del equipo de neurodesarrollo resulta esencial para proporcionar una atención integral a pacientes con SW, la colaboración entre diferentes profesionales con diversos conocimientos y perspectivas puede mejorar la calidad del diagnóstico y aumentar las posibilidades de éxito en la intervención. Existieron limitaciones en la confirmación del diagnóstico por la ausencia de determinación del test de FISH en la cartera de servicios en el sistema de atención salud estatal.
The Effect of Ethnoscience-Based Science Environment Technology Society (SETS) Learning Model in Learning Physics and Biology
Authors: Siagian Gunaria , Santosa Tomi Apra , Festiyed Festiyed , Yerimadesi Yerimadesi 
Published: October 2023

This study investigates the effect of the ethnoscience-based Science Environment Technology Society (SETS) learning model on learning Physics and Biology. This type of research involves systematic research, literature reviews, and meta-analyses. The data sources were taken from an analysis of 100 international journals published from 2018 to 2023. Tracing data sources through Google Scholar, Eric, ScienceDirect, and ProQuest. The process of selecting data sources must meet the inclusion criteria analyzed by the JSAP application. The inclusion criteria in this study are: 1) the journal must be published in 2018–2023; 2) SINTA and Scopus/WOS must index the journal; 3) The journal uses experimental or quasi-experimental research methods; and 4) it has an effect size that can be calculated. The data collection technique is direct observation through the journal database. The results showed that the average effect size (ES = 0.873) is a large criterion. These findings explain that the ethnoscience-based Science Environment Technology Society (SETS) model significantly affects science learning. Furthermore, this SETS learning model helps students learn physics and biology more actively and creatively. These results are very important in evaluating the implementation of the school learning system. Furthermore, this ethnoscience-based SETS model must be applied in learning biology and physics to stimulate students to think critically.
Feature-Based Suitability Study of EIGRP and OSPF Routing Protocols for Healthcare, Banking and Internet Services Enterprises Networks’ Optimization
Authors: Safari Ali Jan , Ahmadi Mahdia , Babakerkhil Mozhdah , Farzad Ahmad Seyar 
Published: October 2023

Due to the broadening of services from industrial enterprises to customers, the industrial network has gained more significance than what is really thought. As a part of this revolution, this paper tried to introduce the best suitable routing option for the healthcare, banking and internet services industries to optimize the routing department of their enterprises. RIP is not associated with this study, being out of favor in the industries due to hop count limitation.
The idea behind doing such a thing is to avoid improper implantation of routing inside the enterprises which causes lack of optimization in routing department. The method which is selected for this paper is qualitative case study of banking, healthcare and internet services industries with unstructured interviews of IT experts of the respected industries in an open-ended questions fashion.
The results were illustrated based on the stories and the discussion of the stories is the main contributor to the result of the study. The evaluation results of the stories have illustrated, that EIGRP is a suitable routing option for health care and banking, while
OSPF can be suitable for the internet services industry.
The implication of the study can be optimized network of industries such as healthcare, banking and internet services and it introduces the best suitable routing option for the demanded industries with the case study method and narrative analysis of the stories, which start from load balancing type and ends to demanded routing protocol, while reaching to demanded routing protocol, it introduces the best suitable routing option of that industry
A Review on the Epidemiology and Mechanism of Actions of Olfactory Dysfunction as a Sequela of SARS-CoV-2 Infection
Authors: Tasnim Nazifa , Ahmed Akash , Khan Nabila , Deen Nadia Sultana 
Published: October 2023

At present Coronavirus disease-2019 (COVID-19) is one of the leading contributing factor to mortality and the impact of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection on the sinonasal tract has become more prominent, particularly with the rising awareness of olfactory dysfunction (OD). We extracted data from published papers available in electronic databases (Wiley online library, PubMed, and Nature). We used the following search terms alone or with combinations - Olfactory dysfunction, SARS-CoV-2, mechanism and treatments. We found worldwide up to 98% of patients confirmed OD due to COVID-19. Current studies have implied that regardless of the high self-reported recovery rate, 25–40% of patients after 1 or 2 months and approximately 15%–28% of patients at six months struggle to fully restore their sense of smell. Moreover, female sex, younger and older age, active smoking, and chronic lung disease are reported as the associated risk factors of OD. Although the pathophysiological mechanism of action(s) of the OD is yet to be explored in depth, central nervous system (CNS) entrance, olfactory bulb (OB) and sustentacular cell damage, neural routes inflammation, non-neuronal cells damage, decreased OB volume and deregulation of olfactory receptor genes are among the commonly reported mechanisms for the development of OD.
Bullet Fragment Retrieval During Intramedullary Nailing
Authors: Serotte Jordan Cook , Cahill Cathleen , Strelzow Jason A. 
Published: October 2023

Case:
Two young adult patients, 22 and 27 years, who sustained ballistic long bone fractures, presented for incarcerated, retained metallic fragments in the medullary canal, which blocked fixation. Owing to the presence and location of the fragments, each case required a bullectomy (removal of the metallic fragment) before intramedullary nail fixation because the projectile impeded the appropriate insertion of the intramedullary rod and, in one case, induced fracture malalignment. Attempts at removal using conventional tools did not provide adequate length or grasp of the retained projectile, necessitating the use of the novel technique. The Babcock Laparoscopic Endopath is an easy-to-use, ubiquitous tool that facilitates the removal of content within the intramedullary canal, including metallic or bony fragments.

Conclusion:
There is limited literature describing accessible, cost-effective techniques for the removal of intramedullary retained metallic foreign fragments when it is unremovable through conventional means. This article reports on a novel, minimally invasive technique for bullet removal from the intramedullary canal of the femur and tibia using the Babcock Laparoscopic Endopath, a tool typically used by urologists. Both patients were followed for at least 8 weeks postoperatively with no complications secondary to the procedure. The article describes the technique and advantages of using this readily available tool that is both flexible enough to navigate through the intramedullary canals as well as rigid enough to obtain and manipulate metallic objects.
Deep Infection After Anterior Cruciate Ligament Reconstruction Diagnosed by Intratunnel Suspensory Fixation Device Migration
Authors: Tsujii Akira , Takami Haruna , Sato Seira , Mae Tatsuo , Ohori Tomoki , Tanaka Hiroyuki , Okada Seiji , Nakata Ken 
Published: October 2023

Case:
A 43-year-old woman sustained an anterior cruciate ligament injury while kickboxing and underwent anterior cruciate ligament reconstruction with hamstring autograft with suspensory fixation. Lateral thigh wound was superficially infected at 2 weeks postoperatively with resolution of signs and symptoms after debridement. Three months later, posterolateral knee pain developed and radiographs revealed intratunnel migration of the device. That observation with abnormal magnetic resonance imaging and serology results led to the diagnosis of deep infection. Immediate device removal and debridement were performed. Consequently, the grafts were preserved, and the patient could perform kickboxing 2 years thereafter.

Conclusions:
Intratunnel migration of suspensory fixation devices can support a diagnosis of infection.
Challenges in Diagnosing Fibrodysplasia Ossificans Progressiva
Authors: K S Meghashyama , Gupta Amit 
Published: October 2023

Case:
A 5-year-old boy presented with multiple bony swellings in the dorsal spine region, restricted left shoulder movement, and a previous misdiagnosis of hereditary multiple exostoses (HMEs) resulting in unnecessary excision of the right scapular lesion. Clinical examination revealed hallux valgus, brachydactyly, and limited neck movement. Radiography and computed tomography confirmed a diagnosis of fibrodysplasia ossificans progressiva (FOP).

Conclusion:
This case report underscores the importance of accurate diagnosis and differentiation between FOP and HME. Hallux valgus, brachydactyly, and restricted neck movement suggested FOP. It is paramount for orthopaedic surgeons to exclude rare disorders before performing any interventions. Biopsies or resections of bone formation areas should be avoided for patients with FOP.
A Lei de Wagner e o Endividamento nos Estados Brasileiros
Authors: de Holanda Nayane Tomé , Rodrigues Junior Manuel Salgueiro , Freitas George Alberto de 
Published: October 2023

RESUMO
Objetivo da Pesquisa: O objetivo deste trabalho é verificar a validade da Lei de Wagner nos estados brasileiros e observar a evolução do endividamento nesses casos.
Enquadramento teórico: Nas finanças públicas, estudos analisam o equilíbrio orçamentário e a perspectiva dos gestores na arrecadação de receitas e execução de despesas. Nessa esteira, a Lei de Wagner considera que a ampliação da renda de um país leva ao crescimento das despesas do governo.
Metodologia: Foi calculada a elasticidade, relacionando despesa, PIB e população para o período de 2002 a 2021. Analisou-se ainda a evolução do endividamento nas unidades da federação brasileira, bem como os fatores determinantes desse endividamento por meio de modelo de painel.
Resultados: A Lei de Wagner foi válida em 35 (14%) das situações examinadas, o que pode ser considerada uma baixa frequência. Em 19 (54%) das 35 vezes em que a Lei foi válida, houve desequilíbrio nos gastos públicos com acréscimo de endividamento na unidade da federação estudada. Corroboram para esse resultado a análise de correlação e a não significância do parâmetro de estimação do modelo de painel. Constatou-se que houve desequilíbrio nos gastos públicos com acréscimo de endividamento na unidade da federação estudada.
Originalidade: O artigo analisa o comportamento das finanças públicas, no tocante à Lei de Wagner, nas unidades federativas do Brasil, objeto de estudo que não fora identificado nos trabalhos anteriores consultados.
Contribuições teóricas e práticas: O estudo traz evidências empíricas que a Lei de Wagner não se mostrou associada ao descumprimento do limite fiscal de endividamento. Os resultados evidenciam a importância de acompanhar a evolução destes indicadores para evitar o comprometimento das finanças públicas.
Palavras-chaves: Gastos Públicos; Equilíbrio Fiscal; Dívida Consolidada Líquida
Evaluation on Vision Intelligent Control and Image Target Location and Recognition Based on Deep Learning
Authors: Zhao Wenhong , Wang Wei 
Published: October 2023

Abstract

Vision is the most important way for human beings to obtain information. Under the constant evolution of electronic imaging technology, visual images are extensively applied to the production and life of people. The analysis of visual image information can achieve intelligent control and complete specific tasks in industrial production. For example, in the logistics parcel sorting, the traditional manual parcel sorting is slow, inefficient and costly. For the logistics parcel sorting system, the machine vision was used to obtain the parcel image information, and the depth learning algorithm was used to locate and recognize the parcel image. In this paper, the depth confidence network algorithm and the convolution neural network algorithm were compared in image positioning and recognition experiments. After several groups of iterative experiments, the results showed that in large package images, the average image recognition accuracy of the depth confidence network algorithm and the convolution neural network algorithm was 94.42% and 96.09% respectively. In the small package image, the average image recognition accuracy of the depth confidence network algorithm and the convolution neural network algorithm were 96.53% and 97.64%, respectively. Therefore, applying convolution neural network to the object recognition of logistics package image can effectively improve the accuracy of image recognition and improve the efficiency of logistics package sorting.
Novel database reveals growing prominence of deep-sea life for marine bioprospecting
Authors: Zhivkoplias Erik , Pranindita Agnes , Dunshirn Paul , Jouffray Jean-Baptiste , Blasiak Robert 
Published: October 2023

Abstract

Perceptions that marine bioprospecting will deliver vast commercial benefits have placed ‘marine genetic resources’ at the center of key policy processes yet our knowledge about their importance remains limited. Here, we introduce a novel global database of marine gene sequences referenced in patent filings, the MArine Bioprospecting PATent (MABPAT) Database. It includes 25,682 sequences from 1,092 marine species associated with 3,258 patent filings, identified by analyzing all relevant sequencerecords from INSDC. Microbial life in the deep sea, a vast and remote biome predominantly beyond national jurisdiction, is already attracting significant commercial interest; all of the top 10 patent holders have filed marine gene patents referencing sequences from deep-sea life, and only three companies, BASF, IFF, and DuPont, included sequences from nearly two-thirds of all species. Our findings underscore the need for policymakers to ensure stewardship of deep-sea ecosystems while providing the most updated understanding of the marine bioprospecting landscape.
Roles of C-reactive protein and its composite index in predicting acute exacerbation of bronchiectasis
Authors: Zhang Jun , Wang Sijiao , Li Zhuozhe , Yan Yu , Du Chunling , Jiang Hongni 
Published: October 2023

Abstract
Background
Bronchiectasis is a heterogeneous chronic respiratory complication characterized by previous lower respiratory infection, airway inflammation and dilation. As the leading cause of frequent hospitalizations and mortality in patients with bronchiectasis, the exacerbation of bronchiectasis remains poorly understood. C-reactive protein (CRP) is one of the extensively studied inflammatory biomarkers related to systemic inflammation. Therefore, we aimed to investigate the relationship between the composite index of CRP and bronchiectasis, especially the potential role of CRP and its composite index in predicting acute exacerbation of bronchiectasis.
Methods
223 patients with stable-stage bronchiectasis between January 1, 2009, and December 31, 2019 in Zhongshan Hospital of Fudan University were enrolled in the retrospectively study. The clinical information of times of acute exacerbations, the frequency of acute exacerbation, pulmonary function, chest computed tomography images, and laboratory findings of sputum examination, serum CRP, CAR (CRP/Albumin ratio), CPR (CRP/Prealbumin ratio) were collected. Based on the frequency of annual acute exacerbations, patients were divided into three groups: 0 times (group A), 1–2 times (group B), and 3 or more times (group C).
Results
There were significant differences in CRP, CAR, CPR, albumin, and prealbumin levels among the three groups, and no significant differences in age, gender, disease duration, involved pulmonary lobes, pulmonary function, and clinical manifestations were observed. The patients in group C had the highest levels of serum CRP (12.25 ± 8.34 mg/l), CAR (0.31 ± 0.25), and CPR (60.83 ± 52.68), and the lowest levels of albumin (41.07 ± 5.61 g/L) and prealbumin (0.21 ± 0.05 g/L). Significant positive correlations were observed between CRP, CAR, CPR, and the frequency of acute exacerbations (P < 0.05), respectively. Ordered logistic regression analysis further identified CRP (odds ratio, OR = 1.140), CAR (OR = 1.125), and CPR (OR = 1.032) as risk factors for frequent acute exacerbations (≥ 3/year). ROC analysis revealed that CRP, CAR, and CPR were effective indexes in predicting at least three times of acute exacerbation per year, whose AUC values are 0.469, 0.464, and 0.460, respectively. Moreover, CAR demonstrated the highest sensitivity (0.742) with an optimal cut-off value of 0.15, while CPR displayed the highest specificity (0.815) with a maximum cut-off value of 43.03.
Conclusion
The levels of serum CRP and its composite index including CAR and CPR were significantly positively correlated with the frequency of acute exacerbations in patients with bronchiectasis. These indicators also showed potential values in predicting over twice acute exacerbation per year, which may help identify patients at risk of experiencing frequent acute exacerbations annually and take timely intervention measures..