bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐rate metal‐free MXene microsupercapacitors on paper substrates
Authors: Xue Han , Huang Po‐Han , Lai Lee‐Lun , Su Yingchun , Strömberg Axel , Cao Gaolong , Fan Yuzhu , Khartsev Sergiy , Göthelid Mats , Sun Yan‐Ting , Weissenrieder Jonas , Gylfason Kristinn B. , Niklaus Frank , Li Jiantong 
Published: January 2024

AbstractMXene is a promising energy storage material for miniaturized microbatteries and microsupercapacitors (MSCs). Despite its superior electrochemical performance, only a few studies have reported MXene‐based ultrahigh‐rate (>1000 mV s−1) on‐paper MSCs, mainly due to the reduced electrical conductance of MXene films deposited on paper. Herein, ultrahigh‐rate metal‐free on‐paper MSCs based on heterogeneous MXene/poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate) (PEDOT:PSS)‐stack electrodes are fabricated through the combination of direct ink writing and femtosecond laser scribing. With a footprint area of only 20 mm2, the on‐paper MSCs exhibit excellent high‐rate capacitive behavior with an areal capacitance of 5.7 mF cm−2 and long cycle life (>95% capacitance retention after 10,000 cycles) at a high scan rate of 1000 mV s−1, outperforming most of the present on‐paper MSCs. Furthermore, the heterogeneous MXene/PEDOT:PSS electrodes can interconnect individual MSCs into metal‐free on‐paper MSC arrays, which can also be simultaneously charged/discharged at 1000 mV s−1, showing scalable capacitive performance. The heterogeneous MXene/PEDOT:PSS stacks are a promising electrode structure for on‐paper MSCs to serve as ultrafast miniaturized energy storage components for emerging paper electronics.
Carboranylphosphines: B9‐Substituted Derivatives with Enhanced Reactivity for the Anchoring to Dendrimers
Authors: Milewski Max , Caminade Anne‐Marie , Mallet‐Ladeira Sonia , Lledós Agustí , Lönnecke Peter , Hey‐Hawkins Evamarie 
Published: January 2024

AbstractSeveral ortho‐carboranes bearing a phenoxy or a phenylamino group in the B9 position were prepared employing various protection and deprotection strategies. Following established protocols, dendritic compounds were synthesized from a hexachlorocyclotriphosphazene or thiophosphoryl chloride core, and possible anchoring options for the B9‐substituted ortho‐carboranes were investigated experimentally and theoretically (DFT). Furthermore, 1‐ or 1,2‐phosphanyl‐substituted carborane derivatives were obtained. The resulting diethyl‐, diisopropyl‐, di‐tert‐butyl‐, diphenyl‐ or diethoxyphosphines bearing a tunable ortho‐carborane moiety are intriguing ligands for future applications in homogeneous catalysis or the medicinal sector.
Numerical analysis of an obstacle motion in the human ureter using the dynamic mesh approach
Authors: Abbasian Saman , Maddahian Reza 
Published: January 2024

AbstractPeristalsis is a common motion in various biological systems, especially the upper urinary tract, where it plays a pivotal role in conveying urine from the kidneys to the bladder. Using computational fluid dynamics, this study aims to investigate the effect of various peristaltic parameters on the motion of an obstacle through a two‐dimensional ureter. Methodologically, Incompressible Navier–Stokes equations were utilized as the fluid domain's governing equations, and the Dynamic Mesh method (DM) was employed to simulate the peristaltic and obstacle motion. The peristaltic motion was modeled by a sinusoidal contraction wave propagating alongside the ureter at the physiological speed, and the motion of the obstruction through the ureter, which is caused by the fluid forces applied on its surface, was explored using the equation of Newton's second law. Various test cases of different shapes and sizes were supposed as kidney stones to understand the influence of the peristalsis properties on the stone removal process. The results show that the motion of the kidney stone is highly influenced by the gradient pressure force applied to its surface in the fluid domain. Moreover, investigating the effects of the peristaltic physical properties on the obstacle's motion indicates that the stone's motion is dependent on these parameters. Furthermore, this analysis provides insight into the peristaltic motion effects, assisting physicians in developing new medicines to facilitate the kidney stone removal process based on its shape and size.
Schema therapy in adults with autism spectrum disorder: A scoping review
Authors: Vuijk Richard , Turner Wesley , Zimmerman David , Walker Hugh , Dandachi‐FitzGerald Brechje 
Published: January 2024

AbstractBackgroundSchema therapy (ST) in adults with autism spectrum disorder (ASD) have gained increasing interest in clinical practice and research. However, to date, there has been no synthesis of the literature on ST as treatment for adults with ASD. Through a scoping review, we aim to summarize the emerging research and literature on ST for adults with ASD.MethodsA comprehensive literature search of three electronic databases was conducted using the Preferred Reporting Items for Systematic reviews and Meta‐Analyses extension for Scoping Reviews (PRISMA‐ScR) guidelines. Publications were included that examined ST in adults with ASD and non‐clinical adults with autistic traits.ResultsSystematic searches identified a total of 11 publications, all published since 2014, with the majority being conducted by Dutch and Japanese researchers. Of the 11 publications, 1 described an ST‐informed social interaction training, 1 was an ST protocol, 2 described conceptual ST models, 2 were case examples, 2 examined early maladaptive schemas (EMSs) and 3 investigated the effectiveness of ST interventions. In summary, the theoretical exploration, practical examples of the application of ST and research findings with preliminary evidence of ST, EMSs and schema modes (SMs) in adults with ASD point towards the potential of ST for the treatment of adults with ASD.DiscussionThe current scoping review highlights preliminary research findings and offers valuable suggestions for clinicians treating adults with ASD. This review underscores the need for development of and research in specialized ST protocols and programmes tailored to adults with ASD with chronic mental conditions, such as personality disorders (PDs).
An ultra‐low‐power CWM/SCM demodulator for inductive‐powered IMDs with the DRCF ratio of 50% and the powering index of 75%
Authors: Arand Farshad Alizadeh , Abiri Ebrahim , Salehi Mohammad Reza 
Published: January 2024

SummaryIn this paper, an ultra‐low‐power and area‐efficient demodulator circuit for wireless downlink SCM/CWM modulation schemes is proposed. The proposed demodulator offers high performances and allows simultaneous power and downlink data transmission over a single 13.56‐MHz inductive link. The proposed method requires only two carrier cycles per data bit period, and also, a power index of 75% is obtained. Although the proposed demodulator can be applicable to other wireless systems, here, it is intended for implantable medical devices. To prove the performance of the proposed demodulator circuit, it has been designed and post‐layout simulations are provided using a standard 65‐nm CMOS technology and occupies 27 × 32 μm2 of active area. Post‐layout simulation results indicate that with a 1‐V power supply, the proposed circuit achieves an ultra‐low‐power consumption of 8.51 μW at a data rate of 6.78 Mb/s corresponding to an energy efficiency of 1.25 pJ/bit.
Androgen‐repressed lncRNA LINC01126 drives castration‐resistant prostate cancer by regulating the switch between O‐GlcNAcylation and phosphorylation of androgen receptor
Authors: Cai Yi , Chen Minfeng , Gong Yuchen , Tang Guyu , Shu Zhiwei , Chen Jiaxian , Zhou Hengfeng , He Yao , Long Zhi , Gan Yu 
Published: January 2024

AbstractBackgroundProstate cancer (PCa) initially shows satisfactory response to therapies targeting the androgen receptor (AR). However, progression to a castration‐resistant stage indicates poor prognosis in PCa patients. AR signalling still plays a central role in most castration‐resistant prostate cancers (CRPC). Therefore, unveiling the mechanisms of AR reactivation under androgen‐deprived conditions is imperative to discover novel therapeutic targets for CRPC.MethodsUsing an integrative analysis of the transcriptomics of three independent PCa cohorts and a published landscape of AR‐regulated long non‐coding RNA (lncRNA), lncRNA LINC01126 was selected as a candidate gene that could drive CRPC progression for further study. Quantitative reverse transcription polymerase chain reaction, in situ hybridisation (ISH) and fluorescent ISH were performed to detect LINC01126 in PCa tissues and cells. The functional role and mechanism of LINC01126 were further investigated using in vitro and in vivo gain and loss of function assays.ResultsLINC01126, identified as an AR‐repressed lncRNA, was significantly upregulated after AR‐targeted therapies. In addition, we found that LINC01126 was upregulated in CRPC and was associated with poor prognosis. We also proved that LINC01126 stabilised AR protein and enhanced AR nuclear translocation and transactivation by promoting the transition from O‐GlcNAcylation at threonine 80 to phosphorylation at serine 81 (S81) within the AR protein. Mechanism analysis revealed that LINC01126 facilitates the interaction of CDK9 with AR and impedes the binding of O‐linked N‐acetylglucosamine (O‐GlcNAc) transferase to AR. Consequently, LINC01126 expression was sufficient to activate AR signalling without androgen. LINC01126 overexpression increased, whereas LINC01126 knockdown decreased castration resistance traits in PCa cells in vitro and in vivo. Furthermore, our data showed that LINC01126‐targeting antisense oligonucleotides (ASO) substantially inhibited CRPC cells in vitro.ConclusionsOur research expands the functions of AR‐regulated lncRNA in sustaining androgen‐independent AR activity and promoting CRPC progression and reveals that LINC01126 may be a new therapeutic target for PCa.
Blood pressure levels and adverse cardiovascular outcomes in heart failure: A systematic review and meta‐analysis
Authors: Seidu Samuel , Lawson Claire A. , Kunutsor Setor K. , Khunti Kamlesh , Rosano Giuseppe M.C. 
Published: January 2024

AimExisting data on the association between blood pressure levels and adverse cardiovascular outcomes in patients with heart failure (HF) are inconsistent. The optimal blood pressure targets for patients with HF remain uncertain. This study sought to assess the associations between blood pressure (systolic [SBP] and diastolic blood pressure [DBP]) levels and adverse cardiovascular disease (CVD) outcomes in patients with HF.Methods and resultsA systematic review and meta‐analysis were conducted using MEDLINE, Embase, the Cochrane Library, and Web of Science databases up to 5 May 2023. The outcomes of interest included adverse cardiovascular events and all‐cause mortality. Pooled relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated. Forty‐three unique observational cohort studies, comprising 120 643 participants with HF, were included. The pooled RRs (95% CIs) for SBP thresholds of ≥140 mmHg versus <140 mmHg were 0.92 (0.83–1.01) for all‐cause mortality, 0.83 (0.67–1.04) for CVD death, and 0.98 (0.80–1.21) for HF hospitalization. The pooled RR (95% CI) for SBP thresholds of ≥160 mmHg versus <160 mmHg and all‐cause mortality was 0.67 (0.62–0.74). SBP levels below <130, <120, and <110 mmHg were each associated with an increased risk of various cardiovascular endpoints and all‐cause mortality. The pooled RR (95% CI) for DBP thresholds of ≥80 mmHg versus <80 mmHg and all‐cause mortality was 0.86 (0.67–1.10). A 10 mmHg increase in SBP or DBP was associated with a reduction in all‐cause mortality and other cardiovascular endpoints.ConclusionsThe findings suggest that lower and normal baseline SBP levels (<130, <120, and <110 mmHg) may be associated with future risk of worse outcomes in patients with HF. Optimal baseline blood pressure levels for these patients may lie within the range of ≥140 mmHg for SBP. In the absence of observational studies with repeated blood pressure measurements or definitive trials evaluating optimal blood pressure targets, individualized blood pressure targets based on patients' unique circumstances are warranted in HF management.
Unveiling the correlation between structural alterations and enhanced high‐voltage cyclability in Na‐deficient P3‐type layered cathode materials via Li incorporation
Authors: Yang Xiaoxia , Wang Suning , Li Hang , Tseng Jochi , Wu Zhonghua , Indris Sylvio , Ehrenberg Helmut , Guo Xiaodong , Hua Weibo 
Published: January 2024

AbstractWith exceptional capacity during high‐voltage cycling, P3‐type Na‐deficient layered oxide cathodes have captured substantial attention. Nevertheless, they are plagued by severe capacity degradation over cycling. In this study, tuning and optimizing the phase composition in layered oxides through Li incorporation are proposed to enhance the high‐voltage stability. The structural dependence of layered Na2/3LixNi0.25Mn0.75O2+δ oxides on the lithium content (0.0 ≤ x ≤ 1.0) offered during synthesis is investigated systematically on an atomic scale. Surprisingly, increasing the Li content triggers the formation of mixed P2/O3‐type or P3/P2/O3‐type layered phases. As the voltage window is 1.5–4.5 V, P3‐type Na2/3Ni0.25Mn0.75O2 (NL0.0NMO, Rm) material exhibits a sequence of phase transformations throughout the process of (de)sodiation, that is, O3⇌P3⇌O3′⇌O3″. Such complicated phase transitions can be effectively suppressed in the Na2/3Li0.7Ni0.25Mn0.75O2.4 (NL0.7NMO) oxide with P2/P3/O3‐type mixed phases. Consequently, cathodes made of NL0.7NMO exhibit a substantially enhanced cyclic performance at high voltages compared to that of the P3‐type layered NL0.0NMO cathode. Specifically, NL0.7NMO demonstrates an outstanding capacity retention of 98% after 10 cycles at 1 C within 1.5–4.5 V, much higher than that of NL0.0NMO (83%). This work delves into the intricate realm of bolstering the high‐voltage durability of layered oxide cathodes, paving the way for advanced sodium‐ion battery technologies.
NOxemission reduction ofcoal‐firedpower plants through data‐driven model and particle swarm optimization
Authors: Abebe Misganaw , Seo Jin , Kang Young‐Jin , Choi Hyunho , Noh Yoojeong 
Published: January 2024

AbstractSeveral studies have aimed to predict and control carbon emissions from coal‐fired power plants. However, the highly complex combustion mechanisms in coal‐fired power plant boilers pose a significant challenge in direct modeling and optimization. To tackle this challenge, this study introduced a data‐driven approach along with model‐based process optimization to mitigate NOx emissions from coal‐fired power plants. The process involved collecting a 5‐month operational dataset containing 67 controllable parameters from a 500 MW coal‐fired power plant. Steady‐state data was isolated from the load output using a moving average method, followed by the application of an isolation forest algorithm to detect and remove anomalies. Correlation analysis was then used to evaluate parameter relationships and eliminate redundant ones. Subsequently, a NOx prediction model was developed, combining an extra tree regressor data‐driven prediction model with particle swarm optimization to optimize the most influential controllable parameters for reducing NOx emissions. Testing the proposed model across four different target loads consistently resulted in a reduction of over 20% in NOx emissions by optimizing boiler combustion parameters, representing a significant achievement in optimizing coal‐fired combustion.
Subjective cognitive complaints and objective cognitive impairment in patients suspected of obstructive sleep apnea who underwent polysomnography
Authors: Rattanabannakit Chatchawan , Kuendee Sorawich , Tungwacharapong Pecharut , Pimolsri Chawanont , Senanarong Vorapun , Chotinaiwattarakul Wattanachai 
Published: January 2024

AbstractObjectivesObstructive sleep apnea (OSA) is linked to cognitive impairment. We aimed to investigate subjective cognitive complaints (SCCs) and objective cognitive scores and their relation to polysomnography (PSG) parameters in patients suspected of having OSA.MethodsA prospective cohort cross‐sectional study was conducted at Siriraj Hospital. Patients suspected of OSA who were scheduled for PSG were recruited. Cognition was assessed using the Montreal Cognitive Assessment (MoCA) and Color Trails Test (CTT). The Memory Index Score (MIS) was calculated from the MoCA. Subjective cognitive complaint presence was assessed through direct questioning of patients and by employing the Cognitive Change Index rated by self or informants (CCI‐I). Patients with severe dementia were excluded.ResultsAmong 258 patients (mean age 61.46 ± 7.05 years, 51.2% female), the mean MoCA score was 23.89 ± 3.89. Based on PSG results, patients were categorized into groups as follows: those without OSA or with mild OSA (combined total of 20.1%), moderate OSA (28.3%), or severe OSA (51.6%). Cognitive Change Index rated by self and CCI‐I scores correlated significantly (r = 0.238, p = 0.019) but not with the MoCA score or CTT time. Objective cognitive scores were associated with PSG parameters: total sleep time (TST), sleep onset latency, wake after sleep onset, sleep stages, mean O2 saturation, and time spent with SaO2 below 90% (all p < 0.05). Subjective cognitive scores were not associated with PSG parameters, except CCI‐I with TST. Participants with objective cognitive impairment had lower education, higher body mass index, more comorbidities, and lower SCC percentage (all p < 0.05). Patients with moderate to severe OSA had a higher proportion of objective cognitive impairment (64.1%) but a lower incidence of SCC (38.3%) than patients with no OSA or mild OSA. Thirty patients with severe OSA and cognitive impairment received continuous positive airway pressure (CPAP) treatment for a mean of 12.2 months. These patients showed MoCA and MIS improvement, but no significant changes were observed in their CTT and Cognitive Change Index scores.ConclusionsMost patients with OSA had objective cognitive impairment, but SCC was less frequent in patients with more severe OSA. Several PSG parameters correlated with cognitive scores but not with subjective cognitive scores. Patients with severe OSA may benefit cognitively from CPAP treatment.
Brain structure ages—A new biomarker for multi‐disease classification
Authors: Nguyen Huy‐Dung , Clément Michaël , Mansencal Boris , Coupé Pierrick 
Published: January 2024

AbstractAge is an important variable to describe the expected brain's anatomy status across the normal aging trajectory. The deviation from that normative aging trajectory may provide some insights into neurological diseases. In neuroimaging, predicted brain age is widely used to analyze different diseases. However, using only the brain age gap information (i.e., the difference between the chronological age and the estimated age) can be not enough informative for disease classification problems. In this paper, we propose to extend the notion of global brain age by estimating brain structure ages using structural magnetic resonance imaging. To this end, an ensemble of deep learning models is first used to estimate a 3D aging map (i.e., voxel‐wise age estimation). Then, a 3D segmentation mask is used to obtain the final brain structure ages. This biomarker can be used in several situations. First, it enables to accurately estimate the brain age for the purpose of anomaly detection at the population level. In this situation, our approach outperforms several state‐of‐the‐art methods. Second, brain structure ages can be used to compute the deviation from the normal aging process of each brain structure. This feature can be used in a multi‐disease classification task for an accurate differential diagnosis at the subject level. Finally, the brain structure age deviations of individuals can be visualized, providing some insights about brain abnormality and helping clinicians in real medical contexts.
Associations between patient‐level health literacy and diagnostic time intervals for head and neck cancer: A prospective cohort study
Authors: Venchiarutti Rebecca L. , Clark Jonathan R. , Palme Carsten E. , Dwyer Patrick , Tahir Abdul Rahim Mohd , Hill Jacques , Ch'ng Sydney , Elliott Michael S. , Young Jane M. 
Published: January 2024

AbstractBackgroundHealth literacy (HL) comprises skills and knowledge required to understand, access, and make decisions about healthcare. Our aim was to examine associations between patient HL and time intervals (defined in the Aarhus statement) along the pathway to treatment of head and neck cancer (HNC).MethodsA prospective cohort study was conducted from October 2018 to March 2020. Participants completed the Health Literacy Questionnaire (HLQ®) and described key events and dates along the pathway to treatment using validated questionnaires. Correlations between six diagnostic time intervals and domains of HL were explored, and factors predicting exceeding maximum acceptable timeframes were assessed using logistic regression.ResultsOne hundred patients with a diagnosis of HNC within the preceding 6 months were recruited. HLQ® Domain 2 (sufficient information to manage health) was significantly negatively associated with four intervals: the patient interval (first symptom to first presentation), primary care interval (first presentation to referral to secondary care), diagnostic interval (first presentation to diagnosis), and total interval (first symptom to treatment onset); correlation coefficients −0.25 to −0.27 (P < 0.05). Domain 8 (ability to find good information) was significantly negatively associated with three intervals (primary care interval, diagnostic interval, and total interval; correlation coefficients −0.23 to −0.34; P < 0.05). Higher education, age, and comorbidity levels were associated with shorter patient and diagnostic intervals.ConclusionsHL may be a potential target to improve timeliness of HNC diagnosis and reduce disparities in outcomes.