bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subcellular localization of S100A11 (S100C) in LLC‐PK1 renal cells: Calcium‐ and protein kinase c–dependent association of S100A11 with S100B and vimentin intermediate filaments
Authors: Bianchi Roberta , Giambanco Ileana , Arcuri Cataldo , Donato Rosario 
Published: March 2003

AbstractThe subcellular localization of the Ca2+‐modulated protein, S100A11, was investigated in the renal cell line LLC‐PK1 by immunofluorescence and confocal laser scanning microscopy under varying experimental conditions. In control cells, S100A11 was detected on the plasma membrane, where the protein co‐localized with annexin I (ANXA1) at discrete sites, and found diffusely in the cytoplasm. Elevation of the cytosolic Ca2+ concentration by means of the Ca2+ ionophore, ionomycin, caused a significant fraction of S100A11 to associate with vimentin intermediate filament (IF)‐bound S100B, another member of the S100 protein family. Under these conditions, ANXA1 underwent a quite different kind of relocation. Translocation of S100A11 onto vimentin IF‐bound S100B was also observed upon activation of protein kinase C (PKC). Under these conditions, S100A11 appeared to associate directly with vimentin IFs at cell sites displaying low or no abundance of S100B such as cell processes, and, again, S100A11 and ANXA1 underwent a different relocation. Our data suggest the possibility that the intracellular Ca2+ level might regulate the subcellular localization of S100A11 and its interaction with definite target proteins, and that S100A11 might serve the function of modulating S100B activities. Interestingly, in spite of the known ability of S100A11 to form heterotetramers with ANXA1, the two proteins underwent a different relocation on elevation of the cytosolic Ca2+ concentration or activation of PKC, pointing to different regulatory activities of individual proteins in renal cells. Microsc. Res. Tech. 60:639–651, 2003. © 2003 Wiley‐Liss, Inc.
Reactions of gaseous acylium ions with 1,3‐dienes: further evidence for polar [4 + 2+] Diels–Alder cycloaddition
Authors: Lemos Aline B. , Sparrapan Regina , Eberlin Marcos N. 
Published: March 2003

AbstractA novel reaction of acylium and thioacylium ions, polar [4 + 2+] Diels–Alder cycloaddition with 1,3‐dienes and O‐heterodienes, has been systematically investigated in the gas phase (Eberlin MN, Cooks RG. J. Am. Chem. Soc. 1993; 115: 9226). This polar cycloaddition, yet without precedent in solution, likely forms cyclic 2,5‐dihydropyrylium ions. Here we report the reactions of gaseous acylium ions [(CH3)2N—C+O, Ph—C+O, (CH3)2N—C+S, CH3—C+O, CH3CH2—C+O, and CH2CH—C+O] with several 1‐oxy‐substituted 1,3‐dienes of the general formula RO—CHCH—C(R1)CH2, which were performed to collect further evidence for cycloaddition. In reactions with 1‐methoxy and 1‐(trimethylsilyloxy)‐1,3‐butadiene, adducts are formed to a great extent, but upon collision activation they mainly undergo structurally unspecific retro‐addition dissociation. In reactions with Danishefsky's diene (trans‐1‐methoxy‐3‐(trimethylsilyloxy)‐1,3‐butadiene), adducts are also formed to great extents, but retro‐addition is no longer their major dissociation; the ions dissociate instead mainly to a common fragment, the methoxyacryl cation of m/z 85. This fragment ion is most likely formed with the intermediacy of the acyclic adduct, which isomerizes prior to dissociation by a trimethylsilyl cation shift. Theoretical calculations predict that meta cycloadducts bearing 1‐methoxy and 1‐trimethylsilyloxy substituents are unstable, undergoing barrierless ring opening induced by the charge‐stabilizing effect of the 1‐oxy substituents. In contrast, for the reactions with 1‐acetoxy‐1,3‐butadiene, both the experimental results and theoretical calculations point to the formation of intrinsically stable cycloadducts, but the intact cycloadducts are either not observed or observed in low abundances. Both the isomeric ortho and meta cycloadducts are likely formed, but the nascent ions dissociate to great extents owing to excess internal energy. The ortho cycloadducts dissociate by ketene loss; the meta cycloadducts undergo intramolecular proton transfer to the acetoxy group followed by dissociation by acetic acid loss to yield aromatic pyrylium ions. Either or both of these dissociations, ketene and/or acetic acid loss, dominate over the otherwise favored retro‐Diels–Alder alternative. The pyrylium ion products therefore constitute compelling evidence for polar [4 + 2+] cycloaddition since their formation can only be rationalized with the intermediacy of cyclic adducts. Copyright © 2003 John Wiley & Sons, Ltd.
Construcution of a Complete Bioelectrocatalytic Electrode Composed of Alcohol Dehydrogenase- and All Electron-transfer Components-modified Graphite Felt for Diol Oxidation
Authors: Kashiwagi Yoshitomo , Pan Qinghai , Kurashima Futoshi , Kikuchi Chikara , Anzai Jun-ichi , Osa Tetsuo 
Published: March 2003

Abstract
A poly(acrylic acid)-coated graphite felt electrode immobilizing all bioelectrochemical reaction components of ferrocene, diaphorase, NADH and alcohol dehydrogenase in the domain of the poly(acrylic acid) layer was applied to oxidize electrocatalytically cis-1,2-cyclohexanedimethanol and 3-methyl-1,5-pentanediol to (+)-(1R, 6S)-cis-8-oxabicyclo[4.3.0]nonan-7-one and (3S)-3-methyl-δ-valerolactone, respectively, in a 0.15 M phosphate buffer (pH 8.0) at the constant potential of 0.45 V vs. SCE with high current efficiency (&gt;92%) and high optical purity (&gt;92%).
Hydrogen-Atom Abstraction from the Solvent by the Lowest Excited Triplet State of Chromone Yielding the β-Keto-Type Solvent Adduct(s)
Authors: Nakayama Toshihiro , Torii Yukiyoshi , Shimizu Tadashi , Miki Sadao , Hamanoue Kumao 
Published: March 2003

Abstract
The lowest excited triplet state of chromone with mixed nπ*-ππ* character abstracts a hydrogen atom from the solvent. Although the ketyl-type radical thus generated is indistinguishable from the β-enol-type radical, this radical (or its keto form, i.e., the β-keto-type radical) gives rise to formation of the β-keto-type solvent adduct(s).
Novel Photochromic System Involving Organostannyl Compounds and 2-Aminomethylpyridine
Authors: Kogure Hideo , Hoshida Yuko , Watanabe Ken-ichiro , Kimura Mutsumi , Hanabusa Kenji , Shirai Hirofusa 
Published: March 2003

Abstract
Photochromic behavior of organostannyl complexes was studied. The addition of 2-aminomethylpyridine to Sn(IV)RnX4-n(n=1∼3) resulted in a reddish purple coloration and it showed the character of photochromism.
Electrocatalytic Reduction of Dioxygen to Water by a Carbon Electrode Coated with (μ-Oxo)bis[(meso-tetraphenylporphyrinato)iron(III)]: a Convenient Template for Cofacially Oriented Iron(II) Porphyrins
Authors: Haryono Agus , Oyaizu Kenichi , Yamamoto Kimihisa , Natori Junichiro , Tsuchida Eishun 
Published: March 2003

Abstract
Electroreduction of an oxo-bridged iron(III) porphyrin dimer adsorbed on an electrode surface produced solid state, cofacially fixed two iron(II) porphyrin molecules when immersed in aqueous acid, allowing an efficient catalysis of the four-electron reduction of O2 to H2O.
The First Spectroscopic Observation of an Equilibrium between a Digermene and Germylenes and Experimental Determination of a Bond Dissociation Energy of a Ge-Ge Double Bond
Authors: Kishikawa Kuniyuki , Tokitoh Norihiro , Okazaki Renji 
Published: March 2003

Abstract
An extremely hindered digermene (E)-Tbt(Mes)Ge=Ge(Mes)Tbt (2; Tbt=2, 4, 6-tris[bis(trimethylsilyl)methyl]phenyl; Mes=mesityl) was synthesized. The temperature dependent change of UV-vis absorptions of 2 in solution indicated the quantitative interconversion between 2 and the corresponding germylene 3. The thermodynamic parameters (ΔH=14.7 ± 0.2 kcal mol−1 and ΔS=42.4 ± 0.8 cal mol−1 K−1) (1cal=4.184 J) for the dissociation of digermene 2 to germylene 3 were obtained from temperature dependence of the absorptions of 2.
Oxidative and Random Cleavage of DNA by the Novel Iron(II) Complex Capable of Yielding an Iron(III) Hydroperoxide Intermediate
Authors: Ishikawa Yoshinobu , Morishita Yuko , Yamamoto Teruo , Kurosaki Hiromasa , Goto Masafumi , Matsuo Hiroaki , Sugiyama Masanori 
Published: March 2003

Abstract
A novel Fe(II) complex and H2O2 system causes sequence non-specific double-strand breaks of duplex DNAs at micromolar concentrations and the DNA cleavage is independent of the presence of hydroxyl radical scavengers. The same system can also oxidize hydrocarbons and the active species in the system is likely to be a Fe(III) hydroperoxide complex supported by characteristic purple absorption and EPR signals.
The New Possibility of Vinylideneruthenium(II) Complexes Derived from Terminal Alkynes: Ring-Opening Metathesis Polymerization of Norbornene Derivatives
Authors: Katayama Hiroyuki , Ozawa Fumiyuki 
Published: March 2003

Abstract
Vinylideneruthenium(II) complexes RuCl2[=C=CH(t-Bu)](PR3)2 (R=Ph, i-Pr, Cy) serve as good catalyst precursors for the ring-opening metathesis polymerization of norbornene derivatives.
Barotropic Phase Transitions and Pressure-induced Interdigitation on Bilayer Membrane of Dimyristoylphosphatidylcholine
Authors: Ichimori Hayato , Matsuki Hitoshi , Kaneshina Shoji 
Published: March 2003

Abstract
The thermotropic and barotropic phase transitions of dimyristoylphosphatidylcholine (DMPC) multilamellar vesicle have been studied. Both temperatures of the main transition and pretransition were elevated by pressure. A pressure-induced interdigitation of DMPC bilayer membrane was observed at high pressures above 300 MPa.
Novel Spiroacetal Synthesis via Hydroboration of Alkynediols
Authors: Fugami Keigo , Hagiwara Nobuhito , Okeda Takeaki , Kosugi Masanori 
Published: March 2003

Abstract
Alkynediols were transformed to the corresponding spiroacetals by the sequence of hydroboration with disiamylborane, oxidation of the resulting alkenylboron intermediate with alkaline hydrogen peroxide, and catalytic treatment with p-TsOH. By this transformation, 6-(2-hydroxymethyl)phenyl-3-methyl-5-hexyn-1-ol was converted to spiro[3,4-dihydro-1H-2-benzopyran-3,2′-[4′]methyl[3′,4′,5′,6′]tetrahydro-2′H-pyran] as a single diastereomer.
Synthesis and Unusual Spectral Properties of (Alkoxycarbonyl)methyl-Substituted Polysilanes
Authors: Hatanaka Yasuo , Okada Shingo , Onozawa Shun-ya , Suzuki Yohichi , Tanaka Masato 
Published: March 2003

Abstract
UV–vis spectra of partially branched polysilanes having (alkoxycarbonyl)methyl substituents exhibit unusual spectral properties such as absorption of very long wavelength and temperature- and solvent-dependent change of the spectra. These observations suggest that polar substituents effectively promote the σ-conjugation of the silicon backbones.
Synthesis of 4-Hydroxy-3-quinolinecarboxylic Acid Derivatives by a Condensation/Cyclization Sequence between o-Isocyanobenzoates and Magnesium Enolates
Authors: Kobayashi Kazuhiro , Nakashima Toshio , Mano Masaaki , Morikawa Osamu , Konishi Hisatoshi 
Published: March 2003

Abstract
Addition of magnesium ester and amide enolates, generated using an excess amount of a magnesium amide (from diisopropylamine and ethylmagnesium bromide), to o-isocyanobenzoates affords 4-hydroxy-3-quinolinecarboxylic esters and amides by a tandem Claisen-type condensation/cyclization sequence.
Molecular Design of Low Molecular-weight Aqueous Gels Bearing an Azo-hydrazone Tautomeric Group Useful as a Solvent Polarity Probe
Authors: Amaike Masato , Kobayashi Hideki , Shinkai Seiji 
Published: March 2003

Abstract
Novel low molecular-weight gelators for aqueous gels were exploited by systematically search varying sugars and adjusting hydrophilic/lipophilic balance. The azonaphthol group was used as a lipophilic group, which was also useful as a measure of the microscopic solvent polarity. From the azo-hydrazone tautomerism the polarity in the gelator aggregates was estimated to be much less polar than that in the gelation media.
Molecular Wrapping of a Fluorescent Dye with TiO2-Gel and Capping Reagents
Authors: Ichinose Izumi , Kunitake Toyoki 
Published: March 2003

Abstract
A fluorescent molecule, fluorescein, was covered with an ultrathin TiO2-gel layer and the resulting nano-particles were stabilized by additional capping. Electron microscopy suggested aggregation and subsequent capping of wrapped fluorescein. The molecular wrapping was effective for suppressing fluorescence quenching by iodine.
A Novel Method for the Synthesis of Thiols from the Corresponding Olefins by Using Thiocarbonates and Ti(IV) Halides
Authors: Mukaiyama Teruaki , Saitoh Terunobu , Jona Hideki 
Published: March 2003

Abstract
A convenient method for the preparation of secondary or tertiary thiols from the corresponding olefins was established by using thiocarbonate, titanium(IV) chloride or fluoride and copper(II) oxide. Various thiols were obtained regioselectively in good to excellent yields according to the Markovnikov rule.
Aromatization of Highly Alkyl-substituted Dihydroanthracenes Using n-BuLi/TMEDA/MeI
Authors: Kitamura Masanori , Shen Baojian , Liu Yanjun , Zheng Hegen , Takahashi Tamotsu 
Published: March 2003

Abstract
Aromatization of highly alkyl-substituted dihydroanthracene was performed with the n-BuLi/TMEDA/MeI. Treatment of 1,2,3,4,5,6,7,8-octapropyl-9,10-dihydroanthracene with 2.2 equiv of n-BuLi, TMEDA at 50 °C in hexane for 3 h, followed by 1.1 equiv of MeI at room temperature for 1 h gave the corresponding anthracene in 98% yield.
Effect of Mn Doping on the Electronic Structure of ZnGa2O4 with Spinel-Type Structure
Authors: Nonaka Moriyasu , Tanizaki Takumi , Matsushima Shigenori , Mizuno Masataka , Xu Chao-Nan 
Published: March 2003

Abstract
The electronic structures of ZnGa2O4 and ZnGa2O4:Mn are calculated by the discrete variational Xα method on model clusters. For ZnGa2O4, it is found that Zn–O and Ga–O bondings are not perfectly ionic but partially covalent. When a central Zn atom of the cluster is replaced with a Mn atom, the new energy states originating from Mn 3d orbitals appear in the energy gap. The energy levels of t2 up-spin states and e down-spin states seem to relate to the green emission.
Simultaneous Electroanalysis of Ascorbic Acid, Dihydroxyphenylacetic Acid, Homovanillic Acid and Uric Acid Using Gold Electrode Modified with Cationic Self-Assembled Monolayers
Authors: Raj Chellappan Retna , Ohsaka Takeo 
Published: March 2003

Abstract
Cationic self-assembled monolayers (SAMs) of cystamine (CYST) and dithiobishexaneamine (DTH) are utilized for the simultaneous electroanalysis of four different anions, ascorbic acid (AA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and uric acid (UA).
Synthesis of Fluorescent Amorphous Diarylethenes
Authors: Kim Myeong-Suk , Kawai Tsuyoshi , Irie Masahiro 
Published: March 2003

Abstract
1,2-Bis(2-methyl-1-benzothiophen-3-yl)perfluorocyclopentene derivatives having 2,4-diphenylphenyl substituents at 6 and 6′ positions of the benzothiophene rings were synthesized. Both mono- and di-substituted derivatives, compounds 1a and 2a, formed amorphous states at room temperature and their glass transition temperatures were observed at 88 °C and 127 °C, respectively. Remarkable spectral shift of the fluorescence from 650 nm to 450 nm was observed for the amorphous film of closed-ring isomer 2b upon visible (λ &gt; 450 nm) light irradiation.
Oxidative Deamination of Various Primary Amines to the Corresponding Carbonyl Compounds by Using N-tert-Butylphenylsulfinimidoyl Chloride
Authors: Matsuo Jun-ichi , Kawana Asahi , Fukuda Yoshio , Mukaiyama Teruaki 
Published: March 2003

Abstract
Various linear and non-linear primary amines were oxidatively deaminated to afford the corresponding carbonyl compounds in good to excellent yields by the following procedure: (i) initial formation of their N-cyclohexylated or N-mesylated derivatives, (ii) subsequent oxidation of these derivatives by using N-tert-butylphenylsulfinimidoyl chloride (1) and DBU, (iii) one-pot acid-hydrolysis of thus formed imines to carbonyl compounds.
High Performance CO2 Gas Sensing with Combination of Multivalent Ion Conducting Solid Electrolytes with Water-Insoluble Auxiliary Electrode
Authors: Imanaka Nobuhito , Ogura Akio , Kamikawa Masayuki , Adachi Gin-ya 
Published: March 2003

Abstract
A carbon dioxide gas sensor was fabricated by combination of multivalent cation and anion conducting solid electrolytes with a water-insoluble Li and Ba codoped Nd2O2CO3 solid solution as an auxiliary electrode. The present sensor shows such a high durability not only in the atmosphere of gas phase water vapor coexistence but also after the exposure to the liquid phase water dew, in addition to persisting the rapid, reproducible response with a high stability from the operation.
Spectroscopic Evidence for Cooperative Binding of a Host in Molecular Hinge
Authors: Kitamura Noboru , Suzuki Yusuke , Chiba Masahiro , Sakata Norio , Kim Haeng-Boo 
Published: March 2003

Abstract
Recognition of a thymine derivative by a molecular-hinge type compound was investigated on the basis of absorption and fluorescence spectroscopies. Spectroscopic evidence for hydrogen-bonding and charge-transfer interactions in molecular recognition was demonstrated.
Use of 1-Methoxy-1-trimethylsilylallene Oxide and Titanium Tetraiodide as a Dianion Synthon of Methoxyacetone
Authors: Hayakawa Ryuuichirou , Makino Hiroaki , Shimizu Makoto 
Published: March 2003

Abstract
A dianion equivalent of methoxyacetone was successfully generated using 1-methoxy-1-trimethylsilylallene oxide and titanium tetraiodide and subsequent reaction with acetals or aldehydes gave α-methoxy-α,β-unsaturated ketones in good yields.
Hydrothermal Synthesis and Characterization of Single-Molecular-Layer MoS2 and MoSe2
Authors: Peng Yiya , Meng Zhaoyu , Zhong Chang , Lu Jun , Yu Weichao , Jia YunBo , Qian Yitai 
Published: March 2003

Abstract
Single-molecular-layer (SML) MoS2 and MoSe2 were synthesized by a hydrothermal method at 150–180 °C. XPS, XRD, ICP, and TEM were used to characterize the samples, and BET study indicated that the SML MoS2 has very large surface area. And it was found that the SML MoS2 has strong ability to catalytically decompose hydrazine monohydrate, just like platinum black.
Spectroscopy and Photocurrent Generation in Nanostructured Thin Films of Porphyrin–Fullerene Dyad Clusters
Authors: Imahori Hiroshi , Hasobe Taku , Yamada Hiroko , Kamat Prashant V , Barazzouk Said , Fujitsuka Mamoru , Ito Osamu , Fukuzumi Shunichi 
Published: March 2003

Abstract
Porphyrin–fullerene dyad cluster films, when cast on nanostructured SnO2 films, are photoelectrochemically active and generate anodic photocurrent under visible light excitation (maximal IPCE value = ∼ 0.4%).
Photo- and Proton-Coupled Isomerization of Novel Azo-Conjugated Platinadithiolene Complex
Authors: Nihei Masayuki , Kurihara Masato , Mizutani Jun , Nishihara Hiroshi 
Published: March 2003

Abstract
A platinum tolylazophenylenedithiolato complex was synthesized. This new azo-conjugated complex shows reversible trans-to-cis photoisomerization, protochromism, and novel proton-coupled cis-to-trans isomerization.
Reductive Dechlorination of α,ω-Dichloroalkanes Adsorbed on Molecular Sieve 13X
Authors: Yamamoto Yukio , Tagawa Seiichi 
Published: March 2003

Abstract
Reductive dechlorination of chlorinated alkanes adsorbed on molecular sieve 13X occurs at room temperature. The dechlorination yields for α,ω-dichloroalkanes, such as 1,4-dichlorobutane, 1,5-dichloropentane, and 1,6-dichlorohexane, did not exceed 50%, suggesting that only one of the chlorine atoms is activated for the reductive dechlorination in the cage of the molecular sieve. Effects of an irradiation with γ-rays on the dechlorination are described.
Formal Total Synthesis of Testudinariol A, a Triterpene with C2 Symmetry
Authors: Hioki Hideaki , Hamano Masayo , Kubo Miwa , Uno Tomoko , Kodama Mitsuaki 
Published: March 2003

Abstract
The alcohol corresponding to half of the molecule of testudinariol A, a triterpene with a symmetric C2 structure isolated from Pleurobrancus testudinarius, was enantioselectively synthesized. The alcohol has been converted to testudinariol A by Mori et al.
Structure and Properties of Diastereoisomers of a Ruthenium(II) Complex Having a Pyridylpyrazoline Derivative as a Ligand
Authors: Wang Pengfei , Onozawa-Komatsuzaki Nobuko , Katoh Ryuzi , Himeda Yuichiro , Sugihara Hideki , Arakawa Hironori , Kasuga Kazuyuki 
Published: March 2003

Abstract
Diastereoisomers of a heteroleptic ruthenium complex, [Ru(bpy)2L]2+ (bpy = 2,2′-bipyridine, L = 5-(4-nitrophenyl)-1-phenyl-3-(2-pyridyl)-2-pyrazoline) have been isolated. Two isomers have quite similar redox potentials and show MLCT absorptions in the region of 400 to 500 nm with similar absorption maxima at room temperature. By contrast, quite different emission maxima and lifetimes are observed at 77 K.
Synthesis and Optical Resolution of an anti-O,O′-Dialkylated Calix[4]arene
Authors: Narumi Fumitaka , Yamabuki Waka , Hattori Tetsutaro , Kameyama Hiroshi , Miyano Sotaro 
Published: March 2003

Abstract
Proximally O,O′-disiloxane-bridged calix[4]arene (1) was treated with benzyl bromide in the presence of Cs2CO3 to afford, after desilylation, anti-O,O′-dibenzylcalix[4]arene (4a) in 90% yield. Chromatographic separation of its diastereomeric (S)-2-methoxy-2-(1-naphthyl)propionic esters allowed the first optical resolution of this kind of dialkylated calix[4]arenes.
Spin Crossover Complex Film, [FeII(H-trz)3]-Nafion, with a Spin Transition around Room Temperature
Authors: Nakamoto Akio , Ono Yuuki , Kojima Norimichi , Matsumura Daiju , Yokoyama Toshihiko 
Published: March 2003

Abstract
We have synthesized [FeII(H-trz)3]n complex film by using ion-exchange resin(Nafion) as counter anion, and have found the spin crossover phenomenon about at 260 K. Moreover, we have proved the existence of straight one-dimensional Fe chain structure of [FeII(H-trz)3]n on Nafion by means of EXAFS.
New VUV Phosphor, NaLnGeO4:Eu3+ (Ln = Rare Earth)
Authors: Toda Kenji , Imanari Yu-ichiro , Nonogawa Takashi , Uematsu Kazuyoshi , Sato Mineo 
Published: March 2003

Abstract
The synthesis and luminescence properties of Eu3+-doped ordered olivine-type NaLnGeO4 (Ln = rare earth) phosphors are reported. Under vacuum-UV (VUV) excitation, this phosphor showed intense red emission due to the 5D0-7F2 transition. The Na(Y0.3Gd0.65Eu0.05)GeO4 phosphor with optimum composition and synthetic condition under 147 nm excitation were higher than those of (Y0.95Eu0.05)2O3.
Estrogen‐induced glial IL‐1β mediates extrinsic retinal ganglion cell vulnerability in murine Nf1 optic glioma
Authors: Tang Yunshuo , Chatterjee Jit , Wagoner Ngan , Bozeman Stephanie , Gutmann David H. 
Published: January 2024

AbstractOptic pathway gliomas (OPGs) arising in children with neurofibromatosis type 1 (NF1) can cause retinal ganglion cell (RGC) dysfunction and vision loss, which occurs more frequently in girls. While our previous studies demonstrated that estrogen was partly responsible for this sexually dimorphic visual impairment, herein we elucidate the underlying mechanism. In contrast to their male counterparts, female Nf1OPG mice have increased expression of glial interleukin‐1β (IL‐1β), which is neurotoxic to RGCs in vitro. Importantly, both IL‐1β neutralization and leuprolide‐mediated estrogen suppression decrease IL‐1β expression and ameliorate RGC dysfunction, providing preclinical proof‐of‐concept evidence supporting novel neuroprotective strategies for NF1‐OPG‐induced vision loss.