bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of psychiatric disorders with clinical diagnosis of long COVID in US veterans
Authors: Nishimi Kristen , Neylan Thomas C. , Bertenthal Daniel , Seal Karen H. , O'Donovan Aoife 
Published: February 2024

AbstractBackgroundPsychiatric disorders may be a risk factor for long COVID, broadly defined as COVID-19 conditions continuing three months post-acute infection. In US Veterans with high psychiatric burden, we examined associations between psychiatric disorders and clinical diagnosis of long COVID.MethodsWe conducted a retrospective cohort study using health records from VA patients with a positive SARS-CoV-2 test from February 2020 to February 2023. Generalized linear models estimated associations between any psychiatric disorder and likelihood of subsequent diagnosis with long COVID (i.e. two or more long COVID clinical codes). Models were adjusted for socio-demographic, medical, and behavioral factors. Secondary models examined individual psychiatric disorders and age-stratified associations.ResultsAmong 660 217 VA patients with positive SARS-CoV-2 tests, 56.3% had at least one psychiatric disorder diagnosis and 1.4% were diagnosed with long COVID. Individuals with any psychiatric disorder had higher risk for long COVID diagnosis in models adjusted for socio-demographic factors, vaccination status, smoking, and medical comorbidities (relative risk, RR = 1.28, 95% CI 1.21–1.35), with the strongest associations in younger individuals. Considering specific disorders, depressive, anxiety, and stress-related disorders were associated with increased risk for long COVID diagnoses (RRs = 1.36–1.48), but associations were in the opposite direction for substance use and psychotic disorders (RRs = 0.78–0.88).ConclusionsPsychiatric disorder diagnoses were associated with increased long COVID diagnosis risk in VA patients, with the strongest associations observed in younger individuals. Improved surveillance, treatment, and prevention for COVID-19 and its long-term sequelae should be considered for individuals with psychiatric conditions.
Neuroadaptive Bayesian optimisation can allow integrative design spaces at the individual level in the social and behavioural sciences… and beyond
Authors: Haartsen Rianne , Gui Anna , Jones Emily J. H. 
Published: February 2024

Abstract
Almaatouq et al. propose an integrative experiment design space combined with large samples for scientific advancement. We argue recent innovative designs combining closed-loop experiment designs and Bayesian optimisation allow for integrative experiments at an individual level during a single session, circumventing the necessity for large samples. This method can be applied across disciplines, including developmental and clinical research.
Replies to commentaries on beyond playing 20 questions with nature
Authors: Almaatouq Abdullah , Griffiths Thomas L. , Suchow Jordan W. , Whiting Mark E. , Evans James , Watts Duncan J. 
Published: February 2024

Abstract
Commentaries on the target article offer diverse perspectives on integrative experiment design. Our responses engage three themes: (1) Disputes of our characterization of the problem, (2) skepticism toward our proposed solution, and (3) endorsement of the solution, with accompanying discussions of its implementation in existing work and its potential for other domains. Collectively, the commentaries enhance our confidence in the promise and viability of integrative experiment design, while highlighting important considerations about how it is used.
Clinical isolate characteristics and demographics of patients with C.jejuni and C.coli infections in Northern Israel, 2015–2021
Authors: Tsafrir Ofri , Rohana Hanan , Bousani Lior , Orsan Khatib , Abozaid Said , Azrad Maya , Peretz Avi 
Published: February 2024

Abstract
C.coli is a significant cause of foodborne gastroenteritis worldwide, with the majority of cases attributed to C.jejuni. Although most clinical laboratories do not typically conduct antimicrobial susceptibility testing for C.coli, the rise in resistant strains has underscored the necessity for such testing and epidemiological surveillance. The current study presents clinical isolate characteristics and demographics of 221 patients with C.coli (coli and jejuni) infections in Northern Israel, between 2015 and 2021. Clinical and demographic data were collected from patient medical records. Susceptibility to erythromycin, tetracycline, ciprofloxacin, and gentamicin was assessed using the standard E-test. No significant correlations were found between bacterial species and patient ethnicity, patient gender, or duration of hospitalization. In contrast, significant differences were found between infecting species and patient age and age subgroup (P < 0.001). Furthermore, erythromycin resistance was observed in only 0.5% of the study population, while resistance to ciprofloxacin, tetracycline, and gentamicin was observed in 95%, 93%, and 2.3% of the population, respectively. The presented study underscores the need for routine surveillance of C.coli antibiotic resistance.
Immune response to SARS-CoV-2 variants after immunization with different vaccines in Mexico
Authors: Garay Erika , Whelan Sean P. J. , DuBois Rebecca M. , O’Rourke Sara M. , Salgado-Escobar Angel Eduardo , Muñoz-Medina José Esteban , Arias Carlos F. , López Susana 
Published: February 2024

Abstract
There is limited information on the antibody responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in subjects from developing countries with populations having a high incidence of co-morbidities. Here, we analysed the immunogenicity of homologous schemes using the ChAdOx1-S, Sputnik V, or BNT162b2 vaccines and the effect of a booster dose with ChAdOx1-S in middle-aged adults who were seropositive or seronegative to the SARS-CoV-2 spike protein before vaccination. The study was conducted post-vaccination with a follow-up of 4 months for antibody titre using enzyme-linked immunosorbent assay (ELISA) and pseudovirus (PV) neutralization assays (PNAs). All three vaccines elicited a superior IgG anti-receptor-binding domain (RBD) and neutralization response against the Alpha and Delta variants when administered to individuals with a previous infection by SARS-CoV-2. The booster dose spiked the neutralization activity among individuals with and without a prior SARS-CoV-2 infection. The ChAdOx1-S vaccine induced weaker antibody responses in infection-naive subjects. A follow-up of 4 months post-vaccination showed a drop in antibody titre, with about 20% of the infection-naive and 100% of SARS-CoV-2 pre-exposed participants with detectable neutralization capacity against Alpha pseudovirus (Alpha-PV) and Delta PV (Delta-PV). Our observations support the use of different vaccines in a country with high seroprevalence at the vaccination time.
Food and nutrition information requirements of Australian primary school parents
Authors: Aydin Gozde , Margerison Claire , Worsley Anthony , Booth Alison 
Published: February 2024

Abstract

Objective:
To explore what Australian primary school parents want to learn about food and nutrition to improve their children’s eating behaviours, as well as the associations between parents’ personal and demographic characteristics and their views regarding their food and nutrition knowledge needs.

Design:
An online nationwide cross-sectional survey was conducted in 2021 using a mixed-methods approach. Logistic regression analysis was utilised to examine the relationship between parents’ demographics, personal values and their views. Content analysis was performed using Leximancer.

Setting:
Australia.

Participants:
Seven hundred and eighty-seven parents.

Results:
Fifty-one per cent wanted to learn more about food and nutrition to improve their children's healthy eating habits, and 77% of those preferred schools to provide that information. Online/printed newsletters and YouTube were the most preferred methods for receiving food and nutrition related information. Higher universalism-concern value (concern for the welfare of those in the larger society and world) scores were positively associated parents’ preference for schools to provide food and nutrition-related information. Parents with non-English-speaking backgrounds and younger parents were more likely to want to learn about food and nutrition. Parents wanted to learn more about encouraging healthy eating, ideas for the lunchbox, food labels and age-specific portion sizes and recommendations.

Conclusions:
Findings can inform public health educators and assist them in designing future food and nutrition education programmes and resources targeting primary school parents.
Epistemic Logic Programs: A Study of Some Properties
Authors: COSTANTINI STEFANIA , FORMISANO ANDREA 
Published: February 2024

AbstractEpistemic logic programs (ELPs), extend answer set programming (ASP) with epistemic operators. The semantics of such programs is provided in terms of world views, which are sets of belief sets, that is, syntactically, sets of sets of atoms. Different semantic approaches propose different characterizations of world views. Recent work has introduced semantic properties that should be met by any semantics for ELPs, like the Epistemic Splitting Property, that, if satisfied, allows to modularly compute world views in a bottom-up fashion, analogously to “traditional” ASP. We analyze the possibility of changing the perspective, shifting from a bottom-up to a top-down approach to splitting. We propose a basic top-down approach, which we prove to be equivalent to the bottom-up one. We then propose an extended approach, where our new definition: (i) is provably applicable to many of the existing semantics; (ii) operates similarly to “traditional” ASP; (iii) provably coincides under any semantics with the bottom-up notion of splitting at least on the class of Epistemically Stratified Programs (which are, intuitively, those where the use of epistemic operators is stratified); (iv) better adheres to common ASP programming methodology.
Pricing of hospital services: evidence from a thematic review
Authors: Sirur Andria J. N. , Pillai K Rajasekharan 
Published: February 2024

AbstractThe management implications of pricing healthcare services, especially hospitals, have received insufficient scholarly attention. Additionally, disciplinary overlaps have led to scattered academic efforts in this domain. This study performs a thematic synthesis of the literature and applies retrospective analysis to hospital service pricing articles to address these issues. The study's inputs were sourced from well-known online repositories, using a structured search string and PRISMA flow chart to select the pertinent documents. Our thematic analysis of pricing literature encompasses: (a) comprehension of hospital service pricing nature; (b) pricing objectives, strategies and practices differentiation; (c) presentation of factors impacting hospital service pricing. We observe that hospital pricing is an intricate and unclear matter. The terms ‘pricing strategies’ and ‘pricing practices’ are often used interchangeably in academic literature. Hospital service pricing is influenced by costs, demand and supply factors, market structure, pricing regulation and third-party reimbursements. The study's findings provide policy implications for service pricing in hospitals, in addition to suggesting avenues for future research on hospital pricing.
Recentering evolution for sustainability science
Authors: Vázquez-Domínguez Ella , Kassen Rees , Schroer Sibylle , De Meester Luc , Johnson Marc T. J. 
Published: February 2024

Abstract

Non-technical summary
Evolutionary biology considers how organisms and populations change over multiple generations, and so is naturally focused on issues of sustainability through time. Yet, sustainability science rarely incorporates evolutionary thinking and most scientists and policy makers do not account for how evolutionary processes contribute to sustainability. Understanding the interplay between evolutionary processes and nature's contribution to people is key to sustaining life on Earth.

Technical summary
Evolution, the change in gene frequencies within populations, is a process of genetically based modification by descent, providing the raw material essential for adaptation to environmental change. Therefore, it is crucial that we understand evolutionary processes if we aim for a sustainable planet. We here contribute to this development by describing examples of contemporary, rapid evolutionary changes of concern for sustainability, specifically highlighting the global spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and how the evolutionary toolbox allowed tracking the origins and evolution of SARS-CoV-2 in real time and predicting potential future outbreaks. We also consider how urban development accelerates evolutionary processes such as altered phenotypic and physiological changes and the spread of infectious and zoonotic diseases. We show the importance of evolutionary concepts and techniques for public-health decision making. Many examples of the potential of evolutionary insights contributing to crucial sustainability challenges exist, including infectious and zoonotic diseases, ecosystem and human health, and conservation of natural resources. We thus join recent calls advocating for a stronger collaboration between evolutionary biologists and the sustainability community, increasing interdisciplinarity and the awareness about the knowledge of evolutionary processes for decision making and policies.

Social media summary
Evolution is fundamental to sustaining life on Earth and should be incorporated in sustainability measures and policies.
Neural Network Parameterization of Subgrid‐Scale Physics From a Realistic Geography Global Storm‐Resolving Simulation
Authors: Watt‐Meyer Oliver , Brenowitz Noah D. , Clark Spencer K. , Henn Brian , Kwa Anna , McGibbon Jeremy , Perkins W. Andre , Harris Lucas , Bretherton Christopher S. 
Published: February 2024

AbstractParameterization of subgrid‐scale processes is a major source of uncertainty in global atmospheric model simulations. Global storm‐resolving simulations use a finer grid (less than 5 km) to reduce this uncertainty by explicitly resolving deep convection and details of orography. This study uses machine learning to replace the physical parameterizations of heating and moistening rates, but not wind tendencies, in a coarse‐grid (200 km) global atmosphere model, using training data obtained by spatially coarse‐graining a 40‐day realistic geography global storm‐resolving simulation. The training targets are the three‐dimensional fields of effective heating and moistening rates, including the effect of grid‐scale motions that are resolved but imperfectly simulated by the coarse model. A neural network is trained to predict the time‐dependent heating and moistening rates in each grid column using the coarse‐grained temperature, specific humidity, surface turbulent heat fluxes, cosine of solar zenith angle, land‐sea mask and surface geopotential of that grid column as inputs. The coefficient of determination R2 for offline prediction ranges from 0.4 to 0.8 at most vertical levels and latitudes. Online, we achieve stable 35‐day simulations, with metrics of skill such as the time‐mean pattern of near‐surface temperature and precipitation comparable or slightly better than a baseline simulation with conventional physical parameterizations. However, the structure of tropical circulation and relative humidity in the upper troposphere are unrealistic. Overall, this study shows potential for the replacement of human‐designed parameterizations with data‐driven ones in a realistic setting.
Cardiac manifestations of human ACTA2 variants recapitulated in a zebrafish model
Authors: Sebastian Wulan Apridita , Inoue Masanori , Shimizu Nobuyuki , Sato Ryosuke , Oguri Saori , Itonaga Tomoyo , Kishimoto Shintaro , Shiraishi Hiroshi , Hanada Toshikatsu , Ihara Kenji 
Published: February 2024

AbstractThe ACTA2 gene encodes actin α2, a major smooth muscle protein in vascular smooth muscle cells. Missense variants in the ACTA2 gene can cause inherited thoracic aortic diseases with characteristic symptoms, such as dysfunction of smooth muscle cells in the lungs, brain vessels, intestines, pupils, bladder, or heart. We identified a heterozygous missense variant of Gly148Arg (G148R) in a patient with a thoracic aortic aneurysm, dissection, and left ventricular non-compaction. We used zebrafish as an in vivo model to investigate whether or not the variants might cause functional or histopathological abnormalities in the heart. Following the fertilization of one-cell stage embryos, we injected in vitro synthesized ACTA2 mRNA of wild-type, novel variant G148R, or the previously known pathogenic variant Arg179His (R179H). The embryos were maintained and raised for 72 h post-fertilization for a heart analysis. Shortening fractions of heart were significantly reduced in both pathogenic variants. A histopathological evaluation showed that the myocardial wall of ACTA2 pathogenic variants was thinner than that of the wild type, and the total cell number within the myocardium was markedly decreased in all zebrafish with pathogenic variants mRNAs. Proliferating cell numbers were also significantly decreased in the endothelial and myocardial regions of zebrafish with ACTA2 variants compared to the wild type. These results demonstrate the effects of ACTA2 G148R and R179H on the development of left ventricle non-compaction and cardiac morphological abnormalities. Our study highlights the previously unknown significance of the ACTA2 gene in several aspects of cardiovascular development.
Optimizing multi-parameter distributed fiber sensors: a hybrid Rayleigh-Brillouin-Raman System approach
Authors: Song Kwang Yong 
Published: February 2024

AbstractAn optimized single-end hybrid Rayleigh, Brillouin, and Raman distributed fiber sensing system has been developed for simultaneous measurement of multiple parameters. This system integrates 3-bit pulse coding for the Raman signal and the Brillouin amplification of the Rayleigh-backscattered signal, discriminating strain, temperature, and vibration using a single sensing fiber.
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission
Authors: Baker Kenneth F. , McDonald David , Hulme Gillian , Hussain Rafiqul , Coxhead Jonathan , Swan David , Schulz Axel R. , Mei Henrik E. , MacDonald Lucy , Pratt Arthur G. , Filby Andrew , Anderson Amy E. , Isaacs John D. 
Published: February 2024

AbstractImmune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing and remitting flares of inflammation. However, the unpredictability of disease flares impedes their study. Addressing this critical knowledge gap, we use the experimental medicine approach of immunomodulatory drug withdrawal in rheumatoid arthritis (RA) remission to synchronise flare processes allowing detailed characterisation. Exploratory mass cytometry analyses reveal three circulating cellular subsets heralding the onset of arthritis flare – CD45RO+PD1hi CD4+ and CD8+ T cells, and CD27+CD86+CD21- B cells – further characterised by single-cell sequencing. Distinct lymphocyte subsets including cytotoxic and exhausted CD4+ memory T cells, memory CD8+CXCR5+ T cells, and IGHA1+ plasma cells are primed for activation in flare patients. Regulatory memory CD4+ T cells (Treg cells) increase at flare onset, but with dysfunctional regulatory marker expression compared to drug-free remission. Significant clonal expansion is observed in T cells, but not B cells, after drug cessation; this is widespread throughout memory CD8+ T cell subsets but limited to the granzyme-expressing cytotoxic subset within CD4+ memory T cells. Based on our observations, we suggest a model of immune dysregulation for understanding RA flare, with potential for further translational research towards novel avenues for its treatment and prevention.
Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain
Authors: Mao Yao-Xu , Chen Zhi-Peng , Wang Liang , Wang Jie , Zhou Cong-Zhao , Hou Wen-Tao , Chen Yuxing 
Published: February 2024

AbstractBilirubin is mainly generated from the breakdown of heme when red blood cells reach the end of their lifespan. Accumulation of bilirubin in human body usually leads to various disorders, including jaundice and liver disease. Bilirubin is conjugated in hepatocytes and excreted to bile duct via the ATP-binding cassette transporter ABCC2, dysfunction of which would lead to Dubin-Johnson syndrome. Here we determine the structures of ABCC2 in the apo, substrate-bound and ATP/ADP-bound forms using the cryo-electron microscopy, exhibiting a full transporter with a regulatory (R) domain inserted between the two half modules. Combined with substrate-stimulated ATPase and transport activity assays, structural analysis enables us to figure out transport cycle of ABCC2 with the R domain adopting various conformations. At the rest state, the R domain binding to the translocation cavity functions as an affinity filter that allows the substrates of high affinity to be transported in priority. Upon substrate binding, the R domain is expelled from the cavity and docks to the lateral of transmembrane domain following ATP hydrolysis. Our findings provide structural insights into a transport mechanism of ABC transporters finely tuned by the R domain.
Stringent sustainability regulations for global supply chains are supported across middle-income democracies
Authors: Smith E. Keith , Kolcava Dennis , Bernauer Thomas 
Published: February 2024

AbstractExpanded international trade and globalised production networks are increasing the environmental and social impacts in middle-income countries (GNI per capita $1,136-$13,845). High-income countries (>$13,845) are seeking to mitigate the negative impacts of domestic consumption by imposing new sustainability regulations on global supply chains. Recent evidence suggests that these regulations are broadly supported across high-income countries. However, it remains unclear whether citizens of middle-income countries support aligning domestic sustainability regulations with the measures developed by high-income countries. Concerns about economic competitiveness and foreign imposition could increase public resistance toward such alignment. Alternatively, desires for continued market access in high-income countries and aspirations for strengthening local environmental and labour regulations could foster support for alignment. Based on survey-embedded experiments in the three largest democratic non-OECD economies (Brazil, India, Indonesia), we find surprisingly strong support for domestic-based measures that are aligned with emerging global supply chain sustainability regulations. Our findings suggest that support is largely driven by positive impact expectations, where the future benefits of alignment are perceived as outweighing concerns about increased costs. These results bode well for initiatives to install stricter sustainability regulations for global supply chains that are acceptable not only in high-income economies but also in non-OECD countries.