bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Temperature on Synthesis of Hydroxyapatite/Chitosan Composite Using the <i>In-Situ</i> Method as a Heavy Metal Adsorbent
Authors: Jamarun Novesar , Amirullah Tri Yupi , Syukri Syukri , Prasejati Arika , Wulandari Wulandari , Caniago Sintia , Tricahyani Nabiila Ayyu 
Published: January 2025

Removing hazardous non-organic waste containing heavy metals like copper and lead is crucial for environmental protection. Adsorption offers a promising solution, with hydroxyapatite (HAp) serving as a biocompatible adsorbent due to its active surface area. However, its mechanical limitations necessitate enhancement through compositing with chitosan (CTS), a natural biopolymer. This study synthesized hydroxyapatite from cuttlefish bone as a calcium source, while chitosan was extracted from shrimp shells. The hydroxyapatite/chitosan (HAp/CTS) composites were prepared in situ at varying temperatures (55, 60, 65, 70, and 75 °C). The composites were characterized using FTIR, XRD, SEM, and SAA. The result indicated successful integration of HAp and CTS, with a crystallite size of 13.82 nm in the 65 °C composite. Based on SEM-EDS analysis, the HAp/CTS 65 °C morphology was agglomerated chunk particles with a Ca/P ratio of 1.61. The highest adsorption capacity value is found in the HAp/CTS 65 °C composite for both ions, 1.9979 mg/g for Cu2+ ions and 0.9965 for Pb2+ ions. The reusability test results of the HAp/CTS 65 °C composite succeeded up to two cycles. This research proves that the adsorption of Cu2+ and Pb2+ ions by HAp/CTS composite adsorbent has been successfully carried out.
The Utilization of <i>Gracilaria</i> sp. as Raw Material for Cellulose in Cellulose Acetate-Nickel Oxide (CA-NiO) as Electrode for Energy Storage Technology
Authors: Karim Abdul , Ahmad Ahyar , Arfah Rugaiyah Andi , Ermawar Riksfardini Annisa , Karim Harningsih , Putra Andi Erwin Eka , Putri Suriati Eka , Negara Satria Putra Jaya , Larekeng Siti Halimah 
Published: January 2025

In the modern era, electrical energy has become a significant need that drives the large consumption of fossil fuels and their environmental impacts. Supercapacitors can reduce this large consumption of natural polymers such as cellulose acetate (CA), which can be synthesized from Gracilaria sp. Composites with CA can be an environmentally friendly alternative electrode with low toxicity. The results show that the cellulose has been successfully synthesized from the algae Gracilaria sp., which was proven by FTIR spectra analysis. The results also show that supercapacitor electrodes have been successfully made where the manufactured electrodes form a composite between CA and nickel oxide (NiO), with the highest specific capacitance and specific energy values of 15.5 × 102 F/g and 13.3 × 102 Wh/kg, respectively, on the CA-NiO2 electrode, but when the NiO concentration is higher than the CA concentration the specific capacitance and specific energy decrease as shown on the CA-NiO electrode with NiO mass of 0.6 g. Thus, the materials results of this study can be applied to electric vehicles and technology that requires electricity storage in the future.
High Potential of Herbal Plant Extracts for Skin Protection from Ultraviolet Radiation
Authors: Le Tien Xuan , Dang Phuong Yen , Tran Uyen Khanh Nguyen , Nguyen Nhu Quynh Trung , Tran Thanh Truc 
Published: January 2025

This research is dedicated to exploring the photoprotective qualities of extracts from 10 different herbal plants to identify natural ultraviolet (UV) filtering agents suitable for use in cosmetics. The study pinpointed specific plant parts that showed promising photoprotective capabilities, including the fruits of Gardenia jasminoides L., the flowers of Chrysanthemum morifolium Ramat., as well as the leaves of Camellia sinensis L. and Moringa oleifera L. Among these, G. jasminoides extracts stood out for their superior photoprotection. Specifically, G. jasminoides led with an impressive in vitro SPF of 40.8 ± 0.2, with C. morifolium, C. sinensis, and M. oleifera trailing closely. Hence, the extracts were added to the base of the lotion cream to evaluate the stability and photoprotective activity. Additionally, even though natural extracts cannot completely replace conventional UV filters, they have substantially decreased the reliance on physical or chemical UV filters. Thus, this study provides a strong foundation for natural antioxidants' status and potential use for UV filtration.
<i>In Silico</i> Investigation of γ-Sitosterol Isolated from the Ethanol Extract of <i>Artocarpus camansi</i> Leaves as a Sunscreen Agent
Authors: Nasution Rosnani , Azura Rafna , Bahi Muhammad , Maulydia Nur Balqis , Bastian Reza Akbar , Hilda Michelia Mutiara , Marianne Marianne 
Published: January 2025

The activity test of sunscreen lotion from the ethanolic extract of Artocarpus camansi leaves was carried out. The activity of sunscreen lotion as sun protecting factor (SPF) is ranging from 28.716 ± 0.1557 to 29.740 ± 0.1360, while the SPF of pure compound is 28.483 ± 0.1422. The type of lotion is water in oil (w/o) with viscosity and pH values in the range of 3057.1–5001.1 cP and 6.86–7.89, respectively. The viscosity and pH values obtained were following the standard SNI 16-4399-1996. The value of dispersion is in the range of 4.60–6.90 cm, while the value of adhesion is in the range of 14.55–25.03 s. The pure compound is thought to be γ-sitosterol by analysis of its molecular weight similarity and positive ion fragment m/z with a melting point of 147 °C. From the molecular docking, it is known that γ-sitosterol has the highest binding affinity value of −7.4 and −8.2 kcal/mol to human neutrophile collagenase (PDB ID: 1BZS) and fibroblast collagenase-1 (PDB ID: 966C), respectively. The presence of active compounds in the ethanolic extract of A. camansi lotion can support the activity of the SPF so that it can be used as a sunscreen formula.
Pemberian Ekstrak Daun Saga untuk Mengatasi Batuk pada Balita
Authors: Kusumastuti Nurry Ayuningtyas , Haeriyah Siti , Sartika Rini , Winarni Lastri Mei 
Published: January 2025

Latar Belakang: Batuk merupakan infeksi saluran pernafasan akut yang paling banyak ditemukan, terutama pada anak-anak di bawah usia 5 tahun. Kejadian batuk ini terjadi 3 sampai 6 kali dalam setahun. Batuk ini akan mempengaruhi kualitas hidup seseorang karena menjadi penghambat dalam proses pertumbuhan dan perkembangan balita. Penanganan batuk yang telah diterapkan oleh penelitian-penelitian sebelumnya menggunakan jeruk nipis, suplementasi madu, minuman jahe dan madu, kunyit, dan kencur.Tujuan: Penelitian bertujuan untuk mengetahui pengaruh pemberian ekstrak daun saga dalam mengatasi batuk pada balita.Metode: Penelitian ini menggunakan metode true eksperimental dengan two group pretest posttest control group design. Jumlah sampel 32 balita yang mengalami batuk akut dibagi menjadi 2 kelompok masing-masing 16 responden, yaitu kelompok intervensi yang diberikan ekstrak daun saga dan kelompok kontrol yang tidak diberikan. Teknik sampling random control trial (RCT). Instrumen menggunakan visual analog scale (VAS) untuk batuk dan SOP untuk pembuatan ekstrak daun saga. Analisis data menggunakan Mann Whitney.Hasil: Hasil penelitian pemberian ekstrak daun saga berpengaruh secara signifikan dalam menurunkan intensitas batuk dengan hasil p-value sebesar 0,009.Kesimpulan: Pemberian ekstrak daun saga dapat mengatasi batuk pada balita di wilayah Kecamatan Margasari.
Dynamics of Oxidative Stress Indices and Endogenous Factors of Vascular Regulation in Patients with Non-Traumatic Subarachnoid Hemorrhage Due to Rupture of Cerebral Aneurysms
Authors: Klychnikova E. V. , Petrikov S. S. , Prirodov A. V. , Bakharev E. Yu. , Silkin S. V. , Tazina E. V. , Temnov A. A. , Bogdanova A. S. 
Published: January 2025

INTRODUCTION The main reasons for the unsatisfactory outcome of surgical treatment of patients with non-traumatic subarachnoid hemorrhage (SAH) due to ruptured cerebral aneurysms are vascular spasm (VS) and delayed cerebral ischemia. Lysis of blood clots in the subarachnoid space leads to the release of a large number of various vasoactive factors that stimulate cytotoxic, inflammatory reactions and oxidative stress, which may be one of the reasons for the development of VS and secondary ischemic brain damage.THE AIM OF THE STUDY Study of the dynamics of oxidative stress indicators and factors of endogenous vascular regulation in patients with non-traumatic SAH due to ruptured cerebral aneurysms.MATERIAL AND METHODS A total of 80 patients in the acute period of SAH due to ruptured cerebral aneurysms were treated and examined. The average age of the patients was 51.7 years. The control group (norm) included 25 practically healthy people, whose average age was 32.7±8.6 years. The study used the blood serum and cerebrospinal fluid of the patients. The study points were 0, 1, 3, and 7 days after the patient’s admission to the hospital. The severity of oxidative stress was assessed by the level of malonic dialdehyde (MDA) and total antioxidant activity of blood serum (TAA); vasotonic function of vascular endothelium by the content of stable metabolites of nitric oxide (NOx) and the concentration of angiotensin-converting enzyme (ACE). Biochemical studies were carried out on the biochemical analyzer “Olympus AU 2700” (Beckman Coulter, USA).RESULTS It was revealed that patients with SAH already had pronounced oxidative stress upon admission to the hospital (increased MDA level, decreased TAA level), which led to an imbalance in the endogenous regulation of vascular tone (decreased NOx level, increased ACE concentration) and increased by the 7th day after admission to the hospital. High lactate dehydrogenase (LDH) activity was observed, the peak of which was on the 7th day of observation. Determination of LDH activity may be promising as a biomarker of ischemic brain injury and a prognostic indicator of the development of an unfavorable outcome.CONCLUSIONS The obtained data indicate the need for a comprehensive approach to the treatment of patients with subarachnoid hemorrhage. The most relevant therapeutic goal is the removal of blood from the subarachnoid space of the brain to prevent increased oxidative stress and angiospasm.
Objective Tools for Assessing the Probability of Acute Appendicitis in Domestic Practice
Authors: Kotkov P. A. , Sigua B. V. , Petrov S. V. , Kozobin A. A. , Esayan I. L. , Chekirov A. A. , Zemlyanoy V. P. 
Published: January 2025

RELEVANCE In order to objectify the diagnosis of acute appendicitis, a number of scales have been developed, the foreign practice of using which implies performing computed tomography in the case of obtaining intermediate point values corresponding to the average probability of acute appendicitis. This tactical solution, which is still difficult to implement in domestic conditions, limits the use of diagnostic scales and serves as a reason to search for other ways of using them.AIM OF THE STUDY To evaluate the external validity of the AIRS, Ripasa, AAS and Alvarado scales on the available clinical material and upon obtaining satisfactory results, to determine the applicability of these classifiers in matters of making specific tactical decisions.MATERIAL AND METHODS The work is based on the analysis of medical records of 293 patients hospitalized with suspected acute appendicitis at the St. Petersburg State Healthcare Institution “Elizavetinskaya Hospital” in the period from 2019 to 2022. Using information on postoperative diagnoses, the values of the AIRS, Ripasa, AAS and Alvarado scores were retrospectively calculated for each of the patients examined, followed by a comparison of the results obtained and the outcomes of hospitalization by conducting a regression analysis.RESULTS The AIRS, Ripasa, AAS, and Alvarado scales for assessing the probability of acute appendicitis, as applied to the analyzed group of patients, demonstrated external validity due to the preservation of referral threshold values, good description of the studied binary variance (AUC greater than 0.8), and sufficiently high adjusted correlation coefficients (from 0.57 and higher). The final diagnostic accuracy for all analyzed classifiers did not differ statistically significantly and was at acceptable levels of 78.8%, 76.7%, 76.7%, and 75.7% for the AIRS, Ripasa, AAS, and Alvarado scales, respectively (p=0.115). The hypothetical choice of the upper limit of low risk as the threshold value after which all patients are subject to diagnostic laparoscopy may lead to a statistically significant decrease in the number of inpatient observations of patients with acute appendicitis without increasing the frequency of diagnostic laparoscopies in healthy patients.CONCLUSION The use of the AIRS, Ripasa, AAS and Alvarado assessment scales is advisable both from the standpoint of diagnosing acute appendicitis and for making tactical decisions, provided that patients with intermediate scale values are shifted towards active surgical actions.
Gastrointestinal Bleeding Associated with Anticoagulant and Antiplatelet Therapy
Authors: Severtsev A. N. , Anosov V. D. , Domrachev S. A. , Ovchinnikov S. V. , Rogozhina L. S. , Solovyev N. O. , Yurchenko I. V. 
Published: January 2025

INTRODUCTION Treatment of gastrointestinal bleeding in patients receiving anticoagulant and antiplatelet therapy is an extremely complex and urgent problem. The risks of recurrent bleeding in such patients are extremely high, while the effectiveness of standard methods of treating gastrointestinal bleeding in this category of patients is lower, compared to the general population. The above served as a prerequisite for this study.MATERIAL AND METHODS In the period from 2020 to 2023, 362 patients receiving antiplatelet or anticoagulant therapy were treated for gastrointestinal bleeding at the O.I. Filatov City Clinical Hospital. All patients underwent endoscopic examination of the gastrointestinal tract, with primary endoscopic hemostasis required in 126 patients (34.8%). Endovascular embolization of the vessel — the source of bleeding. Risk factors for death, need for surgical intervention and recurrence of bleeding were analyzed. The sensitivity and specificity of the Rockall and Glasgow–Blatchford scales for assessing the risk of recurrence of bleeding and the need for surgical intervention in this category of patients were studied.RESULTS Anticoagulant therapy was statistically significantly associated with an increased risk of death. Among the risk factors for death, COVID-19 infection, age over 75 years, and arterial hypertension were statistically significant. Endovascular hemostasis demonstrated the greatest effectiveness embolization , the frequency of recurrent bleeding in this intervention was 5.7%, versus 32.5% in endoscopic interventions. The prognostic significance of the Rockall and Glasgow– Blatchford scales according to the results of our study was insufficient.CONCLUSION The results of the study are consistent with the data of the world literature. It is necessary to take into account the high efficiency of endovascular embolization in this category of patients when choosing a hemostasis method. Risk factors associated with a fatal outcome also do not contradict the generally accepted concept. At the same time, the feasibility and objectives of using current prognostic scales in such patients require further study.Patients over 75 years of age receiving anticoagulant therapy, as well as patients with COVID-19, have a lower risk of death, which must be taken into account when treating such patients (p<0.01).The appropriateness of using the Rockall and Glasgow–Blatchford prognostic scales in this category of patients is low, as evidenced by the low area under the curve (AUC) for the Rockall scale (0.6) and for the Glasgow–Blatchford scale (0.48).
Current View on the Problem of Treatment for Cystic Echinococcosis of the Liver
Authors: Boyarinov V. S. , Novikov S. V. , Rogal M. L. , Yartsev P. A. 
Published: January 2025

Echinococcosis of the liver is an important problem of hematology, which in many cases is solved only with the help of surgical methods of treatment. This is primarily due to the significant number of patients with cystic echinococcosis of the liver in endemic regions, despite the implementation of preventive measures. There are still many complicated and unsolved questions concerning differential diagnostics and choice of tactics of surgical treatment for liver echinococcosis.The problem of surgical treatment of liver echinococcosis is far from its final solution. Depending on the size of the liver lesion area, the nature of the process, severity and type of complications, different forms of treatment for cystic echinococcosis of the liver are chosen. However, during surgical treatment, such complications as liver failure, massive intraoperative bleeding with the development of hemorrhagic shock may develop. After surgical interventions for cystic echinococcosis of the liver, morphologic changes in liver tissues and signs of liver failure do not disappear, but progress; and this negatively affects the longterm treatment outcomes. Therefore, reduction of traumatic operations, prevention of hemorrhagic complications, maximum preservation of functioning liver parenchyma is one of the most important directions of echinococcosis surgery development.In this paper, we analyze the literature sources of PubMed, eLibrary, RINC databases, which are devoted to the comparison of the effectiveness of methods of surgical treatment for cystic echinococcosis of the liver, published for the last 5 years. The conducted analysis of modern literature testifies to the relevance of the problem of choosing the method of surgical treatment for liver echinococcosis.In recent years, there has been intensive development of surgical hepatology, which is associated with the introduction of new technologies in the diagnosis and treatment of patients with various focal liver diseases, including cystic echinococcosis. At the same time at present, there are great differences in surgical indications for treatment of hepatic echinococcosis due to differences in the technical level and experience in conducting or mastering these techniques.
Prevention and Treatment of Intestinal Failure Syndrome in Children with Acute Necrotic Pancreatitis
Authors: Pyhteev D. A. , Elin L. M. , Filyushkin Yu. N. , Elina M. O. , Sokolov Yu. Yu. 
Published: January 2025

AIM OF STUDY To evaluate the effectiveness of intestinal lavage with glucose-saline solution for acute necrotic pancreatitis in children..MATERIAL AND METHODS A retrospective analysis of the diagnosis and treatment of 48 children aged 3 to 17 years with impaired propulsive function of the intestine against the background of acute necrotic pancreatitis of moderate and severe severity was carried out. Intestinal insufficiency syndrome was diagnosed in 39 cases. In the 1st group (n=13) in I A phase in addition to standard therapy, intestinal lavage was performed during the disease phase, in the 2nd group (n=35) the standard therapy for acute necrotic pancreatitis was performed.RESULTS Median the duration of gastrostasis in group 1 was 4 days (IQR, interquartile range: 2; 5), in group 2-6 days (IQR: 4; 7) (from 2 to 13), p=0.0181. The duration of intestinal paresis in group 1 was 2 days (IQR: 2; 4), in group 2–4 days (IQR: 3; 5), p<0.0053. The median time of onset of independent stool in group 1 was 3 days (IQR: 3; 5), in group 2 — 5.5 days (IQR: 4.3; 6), p<0.0014. Reduction in the level of C-reactive protein by day 3–4: in group 1, the median was 8.2 mg/l (IQR: 1.16; 34.6) (from 0 to 46.9), in group 2 — 31.97 mg/l (IQR: 17.71; 112.4) (from 14 to 285), p=0.028. The risk of developing purulent complications was 4-fold higher in group 2, p=0.0088. The duration of hospitalization in the 1st group was shorter, p=0.0004.CONCLUSION Carrying out intestinal lavage in children with impaired propulsive function of the intestine against the background of acute necrotic pancreatitis significantly more quickly restores the function of the gastrointestinal tract and facilitates an earlier start of enteral feeding.
Histopathic Uterine Laceration, Cervix, Vaginal and Bladder Ruptures in a Multiparous Woman During Impetuous Labor
Authors: Managarova O. S. , Shramko S. V. , Alekseeva M. V. , Lesina N. V. , Palina O. V. 
Published: January 2025

BACKGROUND Uterine lacerations are rare but one of the hardest and most dangerous obstetric aftereffects for life of a woman and a baby. Uterine sidewall altered by a scar after caesarean section or laparoscopic myomectomy is recognized as the leading cause of uterine rupture. In turn, histopathic laceration of the uterus during labor, associated with rupture of adjacent organs in a woman with a history of normal childbirth, seems casuistic and deserves discussion.THE AIM OF THE STUDY To present a clinical case of non-operated uterine laceration of a multiparous woman in impetuous labor.MATERIAL AND METHODS A multiparous woman, 35 years old, with histopathic uterine laceration, ruptures of cervix, vagina, and bladder with conization of the cervix in anamnesis in impetuous labor.RESULTS The article describes a clinical observation of histopathic uterine laceration in labor.CONCLUSION A favorable outcome with an organ-preserving surgery in case of histopathic uterine laceration is possible only if the diagnosis of the complication is done timely, and high-quality surgical treatment is carried out within a short space of time. The uterus after the history of cervical conization must be treated as carefully – due to its possible rupture – as the uterus altered by a scar after surgical interventions. Manual examination immediately after impetuous labor with a third-degree cervical rupture would allow for timely diagnosis of uterine laceration, prevention of blood loss and the performance of organ-preserving surgical intervention.
Combined Treatment for Locally Advanced Cardioesophageal Cancer in a Comorbid Patient with Internal Carotid Artery Stenosis
Authors: Domrachev S. A. , Lukyanchikov V. A. , Semenov N. E. , Shatokhin T. A. , Bogdanova O. Yu. , Kulov Z. A. 
Published: January 2025

AIM OF THE STUDY was to present a case of combined, staged surgical treatment for locally advanced cardioesophageal cancer complicated by esophageal stenosis in a comorbid patient with a significant lesion of the internal carotid artery, and to summarize the data of scientific literature on the methods for its diagnosis and treatment.MATERIAL AND METHODS A 65-year-old patient came to the Moscow Clinical Research and Practice Center named after A.S. Loginov in August 2020 with complaints of difficulty in passing solid food through the esophagus. During the examination at the Center, Siewert II cType 3 T4bN2M0 G3 cardioesophageal junction cancer was diagnosed. Taking into account the results of comprehensive diagnostics, the patient was found to have asymptomatic stenosis of the internal carotid artery up to 75%. Step-by-step surgical treatment of the patient was performed.DISCUSSION In the presented clinical observation for prevention of intraand postoperative ischemic complications, at the first stage the patient underwent carotid endarterectomy followed by surgical treatment for the underlying pathology. The presented observation is of interest due to the rare occurrence of such a combination of surgical interventions and the lack of consensus regarding the treatment tactics for this category of patients.CONCLUSION Combined staged treatment of a patient with cardioesophageal cancer and internal carotid artery stenosis reduces the risk of perioperative complications and improves the prognosis of further treatment for the underlying disease.