bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal timing of simethicone administration prior to upper endoscopy: A multicenter, single-blind, randomized controlled trial
Authors: Beaufort I.N. , Verbeek R.E. , Bosman J.H. , Al-Toma A. , Bogte A. , Alvarez Herrero L. , Weusten B.L.A.M. 
Published: October 2023

Abstract
Background and study aims Simethicone is useful as premedication for upper endoscopy because of its antifoaming effects. We aimed to evaluate the effect of timing of simethicone administration on mucosal visibility.
Patients and methods In this multicenter, randomized, endoscopist-blinded study, patients scheduled for upper endoscopy were randomized to receive 40 mg simethicone at the following time points prior to the procedure: 20 to 30 minutes (early group), 0 to 10 minutes (late group) or 20 mg simethicone at both time points (split-dose group). Images were taken from nine predefined locations in the esophagus, stomach, and duodenum before endoscopic flushing. Each image was scored on mucosal visibility by three independent endoscopists on a 4-point scale (lower scores indicating better visibility), with adequate mucosal visibility defined as a score ≤ 2. Primary outcome was the percentage of patients with adequate total mucosal visibility (TMV), reached if all median subscores for each location were ≤ 2.
Results A total of 386 patients were included (early group: 132; late group: 128; split-dose group: 126). Percentages of adequate TMV were 55%, 42%, and 61% in the early, late, and split-dose group, respectively (P < 0.01). Adequate TMV was significantly higher in the split-dose group compared to the late group (P < 0.01), but not compared to the early group (P = 0.29). Differences between groups were largest in the stomach, where percentages of adequate mucosal visibility were higher in the early (68% vs 53%, P = 0.03) and split-dose group (69% vs 53%, P = 0.02) compared to the late group.
Conclusions Mucosal visibility can be optimized with early simethicone administration, either as a single administration or in a split-dose regimen.
Body Weight Satisfaction, Comments, Nutrition and Injury Risk in 489
Adolescent Elite Athletes
Authors: Fridén Cecilia , Ekenros Linda , Hirschberg Angelica Lindén , von Rosen Philip 
Published: October 2023

AbstractExposure to critical body weight comments in youth athletes could lead to
decreased self-esteem, affect body image, and increase the risk of eating
disorders and cause depressive symptoms. The aim was to explore differences
between sex, body mass index, sports type, with regards to body weight
satisfaction, exposure to critical body weight comments from their coach and
nutrition status in adolescent elite athletes. A questionnaire about body
weight, critical body weight comments and nutrition was distributed to 489
adolescent elite athletes and injury prevalence was monitored across 20 weeks.
The results showed that almost one in four athletes (n=116, 24%)
was not satisfied with their weight and 12% (n=59) had received
critical body weight comments from their coach. Of the athletes who were
unsatisfied with their body weight (n=116), 47% wanted to lose
weight (n=55). A significant (p<0.05) higher proportion of ice
hockey players and swimmers used nutritional supplements, were unsatisfied with
their body weight, and were more exposed to critical body weight comments
compared to athletes from other sports. Adolescent elite athletes as young as
15–16 years old are exposed to critical body weight comments from their
coach and experience challenges with body weight satisfaction that is partly
dependent on the sport-specific context.
Recovery Process for Sports-Related Concussion Assessed with Precise
Ocular Motility
Authors: Onodera Hidetaka , Mogamiya Takuma , Yatabe Kanaka , Fujiya Hiroto , Murata Hidetoshi 
Published: October 2023

AbstractOcular motility has been linked to Sports Concussion Assessment Tool 5 scores.
However, the link between ocular motility changes and assessment result changes
remains unclear. Hence, we investigated that potential link in patients with
sports-related concussions. We retrospectively included participants aged≥18
years who were diagnosed with a sports-related concussion. They underwent smooth
pursuit eye movement assessment for allocation to the good improvement (rate of
fundamental frequency≥15%) or minor improvement (<15%) groups. Sports
Concussion Assessment Tool 5 scores were determined at baseline and two weeks
later, and score changes were compared between the groups. Thirteen men
(mean±standard deviation age: 20.6±5.0 years) were included: eight (19.0±4.5
years) in the good improvement group and five (20.6±5.7 years) in the minor
improvement group. Symptom number (median=2.0 vs. 0.0), symptom severity
(median=22.0 vs. 3.0), single-leg stance (median=4.0 vs. 0.5), tandem stance
(median=1.0 vs. 0.0), and total errors (median=5.0 vs. 0.5) were worse (all
p<0.05) in the minor improvement group. Smooth pursuit eye movement
improvements measured using eye-tracking technology was linked to symptom
recovery in patients with sports-related concussions. Therefore, ocular motility
may be an objective indicator of sports-related concussions. Future studies with
more patients are needed to confirm these findings.
Psychometric Evaluation of the Misophonia Impact Questionnaire using a Clinical Population of Patients Seeking Help for Tinnitus, Hyperacusis, and/or Misophonia
Authors: Aazh Hashir , Moore Brian C.J. , Scaglione Tricia , Remmert Nico 
Published: October 2023

Abstract
Background Misophonia is a decreased tolerance of certain sounds related to eating noises, lip smacking, sniffing, breathing, clicking sounds, and tapping. While several validated self-report misophonia questionnaires exist, none focus solely on the impact of misophonia on the patient's life. Additionally, there are no available validated pediatric self-report measures of misophonia. Therefore, a tool was needed to assess the impact of misophonia on both adult and pediatric patients.
Purpose To evaluate the psychometric properties of the 8-item Misophonia Impact Questionnaire (MIQ).
Research Design This was a retrospective cross-sectional study.
Study Sample Patients who attended the Tinnitus and Hyperacusis Therapy Specialist Clinic in the United Kingdom seeking help for tinnitus, hyperacusis, and/or misophonia (n = 256). A subsample of children aged 16 years or younger (n = 15) was included for preliminary analyses of a version of the MIQ to be filled in by a parent (MIQ-P).
Data Collection and Analysis Data were collected retrospectively from the records of patients held at the audiology department. These included demographic data, audiological measures, and self-report questionnaires taken as part of routine care. Descriptive statistics and psychometric analyses were conducted. The MIQ was analyzed for item difficulty, factor structure, reliability, and construct validity.
Results Confirmatory factor analysis revealed that a one-factor model for the MIQ gave an excellent fit and its estimated reliability was excellent, with Cronbach's α = 0.94. The total MIQ scores were highly correlated with scores for the Hyperacusis Impact Questionnaire and Sound Sensitivity Symptoms Questionnaire. MIQ scores were not significantly correlated with scores for the Tinnitus Impact Questionnaire or average hearing thresholds. Preliminary data from the subsample indicated excellent internal consistency for the MIQ-P, with Cronbach's α = 0.92.
Conclusions The MIQ is a promising questionnaire for assessing the impact of misophonia. Future studies should focus on establishing test/retest reliability, identifying clinically significant change in MIQ scores, defining the severity of misophonia impact categories, and further exploring the psychometric properties of the MIQ-P.
Proton Therapy for Skull Base Chondrosarcoma
Authors: Tang Dennis M. , Cutri Raffaello M. , Wu Arthur W. , Patil Chirag , Zumsteg Zachary S. 
Published: October 2023

AbstractChondrosarcoma is a type of an endochondral bone malignancy that is primarily treated surgically with radiation therapy used in the adjuvant setting or in cases of unresectable disease. Proton therapy has potential advantages compared with traditional photon therapy for the treatment of tumors in close proximity to critical structures due to the theoretic lower exit dose. Studies have shown improved survival in patients with skull base chondrosarcoma who undergo proton therapy. However, there is a lack of randomized data. Further studies are needed to define the role of proton therapy in the treatment of skull base chondrosarcoma.
Chiral Cyclodimerization Reactions: Construction of Nonnatural Dimeric Carbazoles from (±)-4-Methylene-3-hydroxytetrahydrocarbazoles
Authors: Baire Beeraiah , Mishra Surabhi , Roy Debayan 
Published: October 2023

AbstractIn this Synpacts article, we describe the concept of cyclodimerization in the biosynthesis and biomimetic synthesis of natural products and unnatural products. We also discuss key details of our discovery and development of a biomimetic-like, selective, homo- and heterochiral cyclodimerization strategy for the construction of nonnatural dimeric carbazole frameworks by employing a formal [3+2] annulation. Our work also demonstrated a novel reactivity of 1-(indol-2-yl)pent-4-yn-3-ols, and their potential as new synthetic building blocks in organic synthesis.1	Introduction: Chiral Cyclodimerization Reactions2	Biomimetic Syntheses of Natural Products through Chiral Cyclodimerizations3	Bioinspired Synthesis of Nonnatural Dimeric Carbazoles through Selective Chiral Cyclodimerizations4	Future Perspectives and Conclusions
Activation of Stable and Recyclable Phenylpropiolate Glycoside (PPG) Donors by Iron Catalysis
Authors: Kumar Amit , Aghi Anjali , Mishra Saksham 
Published: October 2023

AbstractThe glycosylation reaction is one of the important aspects of carbohydrate chemistry, where two different units are frequently linked through C–O bonds. In the pursuit of advancing this field, the design and development of sustainable catalytic methods for O-glycosylation, which can provide an alternate and effective tool to traditional protocols involving stoichiometric promoters and classical donors, are considered as highly challenging, yet important facets of glycochemistry. Herein, we report a simple and efficient Fe(III)-catalyzed method for O-glycosylation through the activation of bifunctional phenylpropiolate glycoside (PPG) donors. This mild and effective method involves the use of the inexpensive and less toxic FeCl3 as catalyst and easily synthesizable, benchtop-stable glycosyl ester-based PPG donors, which react with various sugar as well as non-sugar-based acceptors to deliver the corresponding O-glycosides in good yields with moderate anomeric selectivity, along with regeneration of easily separable phenylpropiolic acid. Importantly, d-mannose and l-rhamnose-based PPG donors afforded the corresponding O-glycosides in high α-anomeric selectivity. The reaction conditions were further explored for the synthesis of trisaccharides.
Benzoxazole or Benzothiazole as an Innate Directing Group for Palladium- and Ruthenium-Catalyzed Complementary C–H Arylation: Functionalization of Biorelevant Heterocyclic Scaffolds
Authors: Seth Kapileswar , Maingle Mohit , Sunny Steeva , Sheeba Loddipalle , Pathan Firojkhan Rajekhan 
Published: October 2023

AbstractThe benzoxazole and benzothiazole moieties were used as innate directing groups for Pd(II)- and Ru(II)-catalyzed C–H arylation of the biorelevant heterocycles 2-arylbenzoxazole and 2-arylbenzothiazole with diverse iodoarenes; palladium and ruthenium catalysis could be used complementarily. The use of σ-donor ligands, such as N,N-dimethylacetamide in the Pd(II) catalytic cycle, and σ-donor/π-acceptor ligands, such as PPh3 in the Ru(II) catalytic cycle, enhanced the arylation rate significantly and was governed by the C–H acidity of the C2-aryl ring of the 2-arylbenzoxazole or 2-arylbenzothiazole. These approaches have a broad substrate scope with respect to coupling partners, to accommodate electron-neutral, electron-rich, as well as electron-deficient iodoarenes; the C2-aryl unit of the 2-arylbenzoxazole or 2-arylbenzothiazole exhibited a high degree of site selectivity at the ortho C–H position, affording only monoarylated derivatives in decent yields; the reactions are functional-group-tolerant and applicable to gram-scale production.
Recent Progress in Developing Thioether-Containing Ligands for Catalysis Applications
Authors: Bellemin-Laponnaz Stéphane , Achard Thierry 
Published: October 2023

AbstractThe ligand that stabilizes the metal center is crucial to its catalytic activity. Historically dominated by phosphorus and nitrogen, sulfur has long been little considered as a hetero element for stabilizing a potentially active metal center. However, this situation is changing and we are seeing more and more examples that incorporate this element. This review provides an overview of recent transition-metal-catalyzed reactions with ligands containing neutral sulfur groups, i.e. thioethers. A selection of examples published since 2013 illustrates the diversity of applications of thioether-containing ligands and shows that sulfur should be more widely used in the development of homogeneous catalysis.1	Introduction2	Phosphorus-Thioether Ligands3	Nitrogen-Thioether Ligands4	Oxygen-Thioether Ligands5	NHC-Thioether Ligands6	Cycloolefin-Thioether Ligands7	Conclusion
Diastereoselective Synthesis of Carbohydrate Conjugates: Pyrano[3,2-c]quinolones
Authors: Singh Brajendra K. , Kumar Sumit , Arora Aditi , Kumar Sandeep , Kumari Priti , Singh Sunil K. 
Published: October 2023

AbstractA facile and efficient protocol for the diastereoselective synthesis of pyrano[3,2-c]quinolone carbohydrate derivatives from Perlin aldehydes and 4-hydroxyquinolones has been developed using a one-pot condensation at room temperature. In this investigation, glucose and galactose were employed as inexpensive starting materials to synthesize two sets of pyrano[3,2-c]quinolone-based carbohydrate conjugates. A total of sixteen novel compounds were successfully synthesized using this methodology in good to excellent yields. The reaction exhibited remarkable diastereoselectivity, resulting in a single diastereomeric product with a diastereomeric excess (dr) 97:3 for glucose, while a diastereomeric mixture with a diastereomeric excess (dr) 67:33 was obtained for galactose. The structural characterization of all sixteen compounds was carried out using various analytical techniques, including IR, 1H NMR, 13C NMR, 1H-1H COSY, 1H-13C HETCOR experiments, 2D NOESY NMR, and HRMS data. Additionally, the scalability of the protocol was successfully demonstrated by synthesizing one of the compounds on a gram scale, highlighting its potential for large-scale production.
Pediatric Acquired Demyelinating Syndrome (ADS)—A Proposed Flowchart for Imaging Diagnosis
Authors: Jeswani Sakshi , Senthilvelan Santhakumar , Ratnaparkhi Chetana , Umredkar Ashwini , Pande Shilpa 
Published: October 2023

AbstractPediatric acquired demyelinating syndromes (ADS) consists of a group of neuroinflammatory disorders, which include monophasic acute disseminated encephalomyelitis, multiple sclerosis, aquaporin-4 antibody-associated neuromyelitis optica spectrum disorder, myelin oligodendrocyte glycoprotein antibody-associated disease, and seronegative ADS. Various advances have been made in understanding their pathology, clinical, and imaging features for providing timely and precise diagnosis to ensure appropriate patient management. Imaging serves as an important tool in not only for diagnosis of demyelination but also helps in distinguishing them. In this case series, the authors have tried to assess distinctive imaging features of these disorders and arrive at an algorithmic approach for the diagnosis of various pediatric demyelinating disorders.
A Randomized Trial of Three Homeopathic Drugs: Rauwolfia serpentina, Viscum album, and Spartium scoparium in Essential Hypertension
Authors: Mandal Dibyendu , Maity Soumyadeep , Shaikh Abdur Rahaman , Ahamed Sabir , Ghosh Priyanka , Mukherjee Shyamal Kumar , Koley Munmun , Saha Subhranil 
Published: October 2023

AbstractHypertension (HTN) remains one of the major risk factors for heart failure, stroke, and coronary heart disease worldwide. This study was undertaken to compare the antihypertensive effects produced by the mother tinctures (MTs) of three homeopathic drugs—Rauwolfia serpentina (RS), Viscum album (VA), and Spartium scoparium (SS; also known as Cytisus scoparius [CS]) in essential hypertension. This open-label, randomized, three parallel arm, pragmatic, pilot trial was conducted on 60 participants with essential hypertension in the outpatient department of D. N. De Homoeopathic Medical College and Hospital, Kolkata. Participants were randomized into three groups: RS, VA, and SS equally. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at baseline and after 30 and 60 minutes. Group differences at different time points and overall were measured using one-way analysis of variance (ANOVA) and three-way repeated measure ANOVA models, respectively, after adjusting for baseline differences using intention-to-treat approaches. A p value less than 0.05 was considered statistically significant. Endpoint analysis included 60 participants. Although the highest mean reductions in SBP and DBP with time were achieved in the RS group, all three medicines revealed similar antihypertensive effects without any significant differences (SBP: F
2, 57 = 1.710, p = 0.190; DBP: F
2, 57 = 0.732, p = 0.485). No harm or serious adverse events were reported from either of the groups. All three medicines (RS, VA, and SS) produced similar antihypertensive effects in essential hypertension.
Trial registration: CTRI/2021/02/031548; UTN: U1111–1264–6856.
The Orthodontic Mini-Implants Failures Based on Patient Outcomes: Systematic Review
Authors: Tarigan Siti Harlianti Putri , Sufarnap Erliera , Bahirrah Siti 
Published: October 2023

AbstractAnchorage is a challenge and essential issue for an orthodontist in determining the success of orthodontic treatment. Orthodontic anchorage is defined as resistance to unwanted tooth movement. Mini-implant is one of the devices that can be used as an anchor in orthodontic treatment. Many cases have reported successful treatment using mini-implant, but there are cases where mini-implants may fail. Failure of mini-implants can affect orthodontic treatment, and it is known that several factors may lead to mini-implant loss in orthodontic treatment. This systematic review aimed to determine the factors influencing mini-implant failure in orthodontic treatment. Articles were selected from electronic databases (PubMed, Google Scholar, The Cochrane Library, ScienceDirect) from January 2015 until 2023 according to the PRISMA method (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) under the PEOS (Population-Exposure-Outcome-StudyType) framework questions for systematic review. The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42022337684). All data collected were in English, and filtering was done by eliminating duplicate data, meta-analysis, case reports, case series, mini-reviews, and animal studies. The analysis was further divided into three groups, that is, patient-related, implant-related, and operator-related and operator-related (A graphical abstract provided as a Supplementary information [available in the online version]). Twenty-one articles were identified according to the inclusion criteria in the form of retrospective, prospective, in vivo, and randomized controlled trial studies. Mini-implant failures due to patient-related showed six etiological factors, failures due to implant-related had eight etiological factors, and only one factor was operator-related, which may lead to mini-implant failure. The data was extracted without a computerized system and only in English. Mini-implant failure can be caused by many factors; we could not accuse one major factor as a cause. However, the quality or condition of the bones and oral hygiene are factors that play a significant role in obtaining the stability of implants. Mini-implant failure is highly influenced by poor oral hygiene and peri-implant inflammation. Comprehensive diagnostic prior to mini-implant insertion should be appropriately considered. This systematic review describes several factors that can influence mini-implant failure, divided into three groups: patient-related, implant-related, and operator-related (A graphical abstract provided as a Supplementary information [available in the online version]).
Allogenic Acellular Dermal Matrix and Xenogeneic Dermal Matrix as Connective Tissue Graft Substitutes for Long-Term Stability Gingival Recession Therapy: A Systematic Review and Meta-Analysis
Authors: Halim Felita Clarissa , Sulijaya Benso 
Published: October 2023

AbstractConnective tissue graft (CTG) serves as a gold standard for gingival recession therapy. Yet the availability of CTG is limited, and it increases patient morbidity. Allogenic acellular dermal matrix (AADM) and xenogeneic dermal matrix (XDM) have been proven to be effective substitutes of CTG although the long-term stability is unclear. The aim of this study was to analyze the long-term stability outcome of gingival recession therapy using AADM and XDM compared to CTG. This study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were extracted independently from several online databases (PubMed, Scopus, and Embase). Five of 233 publications were included for final qualitative analysis and meta-analysis focusing on the mean difference of clinical parameters such as recession depth (RD), recession width (RW), probing depth (PD), clinical attachment loss (CAL), tissue thickness (TT), keratinized tissue width (KTW), and mean root coverage (MRC). Meta-analyses of RD, RW, CAL, TT, KTW, and MRC display an overall mean of 0.2 mm (95% confidence interval [CI]: –0.45 to –0.05), 0.29 mm (95% CI: –0.65 to 0.08), 0.2 mm (95% CI: –0.69 to 0.29), 0.25 mm (95% CI: –0.53 to 0.03), 0.26 mm (95% CI: –0.5 to 0.02), and 9.19% (95% CI: –13.95 to –4.43]), respectively, favoring the CTG. PD was the only parameter that favored the AADM or XDM with an overall mean of 0.03 mm (95% CI: –0.05 to 0.11). In all, if the long-term stability is the goal, the CTG is considered superior for gingival recession therapy. However, if it is contraindicated, the AADM and XDM might be considered as alternatives.