bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maintenance‐phase serum anti‐TNF levels are not associated with mucosal healing in pediatric Crohn's disease
Authors: Grabovski Rinat , Regev Stav , Matar Manar , Weintraub Yael , Shamir Raanan , Shouval Dror S. , Tal Noa 
Published: January 2025

AbstractObjectivesMucosal healing (MH) is a key therapeutic target in Crohn's disease (CD) and is associated with improved outcomes. While adult studies indicate a positive correlation between serum anti‐tumor necrosis factor (TNF) levels and MH, data in pediatric patients is limited. We aimed to define the association of serum anti‐TNF levels with MH in pediatric patients with CD during maintenance therapy.MethodsRetrospective data (2014–2023) was collected from pediatric CD patients treated with infliximab or adalimumab who performed an ileocolonoscopy at least 26 weeks after initiating therapy. Serum anti‐TNF levels around endoscopic time were compared with endoscopic findings. MH was defined as complete absence of inflammatory or ulcerative lesions across all segments of the gastrointestinal tract. Univariable and multivariable logistic regression analysis was conducted to identify factors associated with MH.ResultsData were obtained from 107 patients (41 infliximab and 66 adalimumab), with a median age at diagnosis of 12.6 (9.9–14.0) years. Median time until ileocolonoscopy following anti‐TNF initiation was 89.0 (56.3–152.3) weeks. MH was identified in 31 (29.0%) patients. Anti‐TNF serum levels were comparable in the MH and non‐MH groups (9.5 [4.9–13.9] vs. 9.3 [6.4–15.7] µg/mL; p = 0.73), without differences in patients treated with infliximab or adalimumab. In multivariable analysis, diagnosis weight Z‐score (odds ratio [OR] = 2.860, 95% confidence interval [CI] = 1.005–8.138; p = 0.049), along with C‐reactive protein (OR = 0.037, 95% CI = 0.002–0.687; p = 0.027) and fecal calprotectin (OR = 0.995, 95% CI = 0.990–1.000; p = 0.037) at time of ileocolonoscopy were significantly associated with MH.ConclusionsIn our cohort, anti‐TNF levels during maintenance were not associated with MH in pediatric CD.
A triphenylamine‐based aggregation‐induced emission active fluorescent probe for fluorescent ink, fingerprint powder, and visual detection of salmon freshness
Authors: Zhong Keli , Liu Shuang , Li Yangyang , Tang Lijun , Sun Xiaofei , Li Xuepeng , Li Jianrong 
Published: January 2025

AbstractBackgroundMultifunctional fluorescent probes have attracted much attention due to their wide range of applications and high utilization. In this study, a multifunctional fluorescent probe (E)‐3‐(4‐(7‐(4‐(diphenylamino)phenyl)benzo[c] [1,2,5]thiadiazol‐4‐yl)phenyl)acrylic acid (TBAC) based on triphenylamine was designed and synthesized.ResultsThe TBAC probe provided excellent aggregation‐induced emission (AIE) performance and could be used as a fluorescent ink for printing. It was also prepared successfully for application as a fingerprint powder, facilitating the visual detection of invisible fingerprints on surfaces such as glass, plastic, tinfoil, metal, aluminum, and resin. The probe exhibited a clear fluorescence response to 12 volatile amines via an AIE‐based ‘on–off’ mechanism in an EtOH/H2O (4/6, v/v) solution. The TBAC/bromocresol green (BCG) indicator label also enabled non‐destructive and rapid assessment of salmon freshness through dual‐channel colorimetric and fluorescence responses.ConclusionThe versatility of TBAC makes it a promising material for various applications, including fluorescent materials, criminal detection, and food safety. This study provides a new basis for the multifunctional application of fluorescent probes. © 2025 Society of Chemical Industry.
E74‐like ETS transcription factor 3 expression and regulation in human intervertebral disc
Authors: González‐Rodríguez María , Ait Eldjoudi Djedjiga , Cordero‐Barreal Alfonso , Farrag Mariam , Varela‐García María , Ruiz‐Fernández Clara , Torrijos‐Pulpón Carlos , Lago Francisca , García‐Caballero Lucía , Farrag Yousof , Conde‐Aranda Javier , Pino Jesus , Gualillo Oreste 
Published: January 2025

AbstractBackgroundIntervertebral disc degeneration (IVDD) is one of the main causes of chronic low back pain. The degenerative process is often initiated by an imbalance between catabolic and anabolic pathways. Despite the large socio‐economic impact, the initiation and progress of disc degeneration are poorly understood. Although intervertebral disc (IVD) and articular joint are not identical, their degenerative roads are remarkably similar. We, and another authors, previously demonstrated that E‐74‐like factor 3 (ELF3), a transcription factor induced by inflammatory mediators in various cell types including chondrocytes, is a central contributing factor for cartilage degradation. Thus, we aim to explore, for the first time, the expression, modulation, and the role of ELF3 in human IVD cells.MethodsThe presence of ELF3 in healthy and degenerated IVD tissues was initially determined by immunohistochemistry in annulus fibrosus (AF) and nucleus pulposus (NP). mRNA and protein expression were measured, respectively, by RT‐qPCR and Western blot in AF and NP IVD cells harvested from healthy individuals and IVDD patients. Overexpression of ELF3 was performed by transfection of AF IVDD cells with pESE‐1: ELF3 expression vector or pCI: empty vector.ResultsOur results unveiled, for the first time, the expression of ELF3 in IVD tissues. ELF3 is notably upregulated in degenerated tissues compared to those from healthy patients. In addition, the stimulation of IVDD AF cells with various proinflammatory stimuli, showed marked increase in both mRNA and protein expression of ELF3. ELF3 overexpression in AF IVDD cells resulted in the upregulation of proinflammatory and catabolic genes such as PTGS2, NOS2, LCN2, IL‐6, MMP13, and ADAMTS‐5; whereas, ELF3 silencing resulted in the opposite results.ConclusionsOur results support a novel role for ELF3 as a pro‐inflammatory and pro‐catabolic transcriptional mediator, whose targeting in IVD tissues might be of potential therapeutic relevance in disc degeneration.
Inconsistent Associations of Modified Frailty Index‐5 With Adverse Head and Neck Reconstruction Outcomes
Authors: Orgun Doruk , Bay Caroline C. , Carbullido Kristine M. , Wieland Aaron M. , Michelotti Brett F. , Poore Samuel O. 
Published: January 2025

ObjectivesTo investigate the consistency of associations between modified frailty index‐5 (mFI‐5) and postoperative adverse outcomes in head and neck cancer (HNC) reconstruction.MethodsAmerican College of Surgeons National Surgical Quality Improvement Program (ACS‐NSQIP) database from 2017 to 2022 was utilized to identify HNC patients undergoing locoregional or microvascular free tissue transfers. Kaplan–Meier estimates and multivariable Cox regression analyses were utilized to compare risk of infections, bleeding, readmissions, reoperations, major adverse cardiovascular events (MACE), and mortality within the first postoperative month for each mFI‐5 score with mFI‐5 = 0 as reference. Further analyses investigated associations between individual mFI‐5 components and the outcomes of interest.ResultsWe included 5,573 patients (median age: 64; 31.5% female), 63% (n = 3,519) of whom underwent microvascular free tissue transfers. Unadjusted univariate analyses associated higher mFI‐5 scores with longer hospital stays. In locoregional tissue transfers, adjusted hazard ratios (aHRs) for reoperation were 1.37 (p = 0.03) for mFI‐5 = 1 and 2.19 (p = 0.03) for mFI‐5 ≥ 3. In microvascular free tissue transfers, aHRs for MACE were 1.93 (p = 0.04) for mFI‐5 = 2 and 6.53 (p < 0.001) for mFI‐5 ≥ 3, while aHRs for mortality was 3.88 (p = 0.04) for mFI‐5 ≥ 3. No associations were observed between increasing mFI‐5 scores and increased relative risk of infection, bleeding, or readmission. Individual component analysis associated congestive heart failure with aHRs of 3.92 (1.84–8.35; p < 0.001) for MACE and 5.30 (2.03–13.88; p < 0.001) for mortality. Additionally, COPD was associated with an aHR of 1.39 (1.16–1.67; p < 0.001) for infections.ConclusionThe associations of higher mFI‐5 scores with postoperative adverse outcomes following oncoplastic head and neck reconstruction were inconsistent and possibly driven by individual effects of its components.Level of EvidenceLevel III (three) Laryngoscope, 2025
Are More Adults Bleeding After Tonsillectomy Than in the Past?
Authors: Akella Deepthi , Cottone Chloe , Raghavan Maya , Varavenkataraman Gaayathri , Marcus Chennai A. , Erwin Dylan Z. , Carr Michele M. 
Published: January 2025

ObjectivePost‐tonsillectomy hemorrhage (PTH) rates have increased in children over the last decade. This study aimed to determine whether PTH incidence in adults had also increased over the last 15 years.Study DesignRetrospective study.SettingTriNetX database.MethodsA search was conducted using TriNetX for patients 18 years and older within the US Collaborative Network who had undergone tonsillectomy (CPT codes 42821 or 42826) and yielded 72,232 subjects. PTH diagnoses were identified using ICD‐10 codes J95.830 or K91.840, and those who returned to the operating room (RTOR) to control PTH were identified using CPT 42962. PTH events that occurred and analgesics given following 14 days of tonsillectomy were tabulated annually from 2008 to 2022. Mann‐Kendall test for monotonic trend examined significant trends in PTH and analgesic use.ResultsMean age at tonsillectomy was 32.8 years (SD = 13.8). 4.1% were diagnosed with PTH in 2008, compared with 6.2% by 2022 (p = 0.0030). In 2008, 0.7% required RTOR to control PTH, compared with 2.4% in 2022 (p < 0.0001). Use of codeine decreased from 6.9% in 2008 to 2.5% in 2022 (p = 0.0022). Use of ibuprofen, acetaminophen, ketorolac, and oxycodone increased from 1.6% to 23.4% (p = 0.0005), 36.1% to 78.6% (p < 0.0001), 1.5% to 11.9% (p < 0.0001), and 20.6% to 63.6% (p < 0.0001), respectively. No change was detected in use of hydrocodone.ConclusionPost‐tonsillectomy analgesia in adults has changed significantly over the last 15 years. Our study highlights a concurrent increase in PTH which bears more investigation.Level of Evidence3 Laryngoscope, 2025
Moving Open Repositories out of the Blind Spot of Initiatives to Correct the Scholarly Record
Authors: Bordignon Frédérique 
Published: January 2025

ABSTRACTOpen repositories were created to enhance access and visibility of scholarly publications, driven by open science ideals emphasising transparency and accessibility. However, they lack mechanisms to update the status of corrected or retracted publications, posing a threat to the integrity of the scholarly record. To explore the scope of the problem, a manually verified corpus was examined: we extracted all the entries in the Crossref × Retraction Watch database for which the publication date of the corrected or retracted document ranged from 2013 to 2023. This corresponded to 24,430 entries with a DOI, which we use to query Unpaywall and identify their possible indexing in HAL, an open repository (second largest institutional repository worldwide). In most cases (91%), HAL does not mention corrections. While the study needs broader scope, it highlights the necessity of improving the role of open repositories in correction processes with better curation practices. We discuss how harvesting operations and the interoperability of platforms can maintain the integrity of the entire scholarly record. Not only will the open repositories avoid damaging its reliability through ambiguous reporting, but on the contrary, they will also strengthen it.
Ultralow Turn‐On Voltage Organic Upconversion Devices for High‐Resolution Imaging Based on Near‐Infrared Homotandem Photodetector
Authors: Han Xingwei , Han Chao , He Meiyu , Han Jiayue , Yu He , Gou Jun , Wang Jun 
Published: January 2025

AbstractIn recent years, infrared visualization technology has attracted significant attention, and organic upconversion devices (OUDs) have become a reliable infrared imaging strategy due to the superiority of low cost, simple structure, and large‐area imaging. Nonetheless, the power consumption of OUDs is mostly high, so effectively reducing the turn‐on voltage (Von) has emerged as a crucial aspect in optimizing OUD performance, alongside the urgent need to enhance imaging resolution. This work presents an efficient OUD integrating a homotandem photodetector and an organic light‐emitting diode to reduce the Von of the OUD since the homotandem detection unit can generate nearly twice the open‐circuit voltage (Voc) compared to the single detection unit. The device reaches a noteworthy Von of 0.64 V, which is the lowest Von reported for OUDs, accompanied by a high upconversion efficiency of 10.64% and a wide luminance linear dynamic range (L‐LDR) of 82.94 dB. In addition, high‐quality bioimaging with wide operating voltages is demonstrated, achieving imaging resolution up to 5799 pixels per inch (ppi). This work demonstrates an effective technical approach to reduce the power consumption of OUDs and facilitate future bioimaging applications.
Manufacturing and Biological Potential of Saliva‐Loaded Core‐Sheath Pressure‐Spun Polymeric Fibers
Authors: Thukral Vansh , Qosim Nanang , Kurniawan Andre , Gültekinoğlu Merve , Herath H.M. Thushari U. , Williams Gareth R. , Edirisinghe Mohan 
Published: January 2025

AbstractThe rich array of antimicrobial components in saliva offers alternative treatments for drug‐resistant bacteria. One therapeutic challenge associated with the effective delivery of salivary components is the quick degradation of salivary proteins outside the oral environment. In this study, polyethylene oxide (sheath) and polycaprolactone (core) based fibers are successfully synthesized using the pressurized gyration technique. Six different pressure‐spun fibers are produced. These fibers are created by varying the quantity of artificial saliva in the sheath layer. This unique and effective methodology of embedding saliva within the sheath of the fiber exhibits enhanced bacterial inhibition against Escherichia coli and Staphylococcus aureus with 80% and 78% inhibition efficiency, respectively. This study showcases a novel technique for promoting wound healing, utilizing core‐sheath fibers, which have tremendous potential because of their superior antimicrobial properties, while also aiding in the process of epithelialization. In vitro, cytotoxicity test results showed that there is no cytotoxic effect on the fibroblast cell line. As a result, it is evaluated that the produced fiber meshes can be ideal wound dressing material, considering their lack of toxic effects and high antibacterial activity levels.
Solvent‐Free, Degradable Resins for 3D Inkjet Printing Based on Silyl Ether and Amino Acid Phosphoramide Photomonomers
Authors: Haudum Stephan , Kainz Michael , Stubauer Gerald , Wanko Sascha , Guillén Elena , Brüggemann Oliver , Müller Stefanie Monika , Dehne Tilo , Schulz Daria Patrycja , Engels Andreas , Rinner Uwe , Griesser Thomas , Teasdale Ian 
Published: January 2025

AbstractInkjet 3D printing is a fast, reliable and noncontact method, capable of producing small and large structures and enabling multi‐material printing. These characteristics make inkjet an excellent printing technique for additive manufacturing of biomaterials, such as scaffolds for tissue engineering. However, the technology is restricted by the limited number of suitable photopolymers which hitherto are limited to acrylate‐based chemistries, which are not only toxic but nondegradable, thus of limited use in many biomaterials‐based applications. Herein, a unique and innovative approach is described looking beyond traditional carbon‐based chemistry to design and synthesize novel photomonomers based on amino acid phosphoramides (APA) with silyl ethers utilizing thiol‐yne click chemistry. The novel inks are specifically designed for use in solventless 3D inkjet printing of biomaterials and are shown to be biocompatible and having fast and tunable degradation rates. This makes these innovative inks a promising material for biomedical 3D printing applications, such as tissue regeneration.
Polysiloxane‐Modified PMMA‐Shell Phase Change Microcapsules for Thermal Management Fabrics
Authors: Chen Yang , Lu Xinbo , Liu Ziqiang , Xiao Weiqiang , Song Lina , Lang Linquan , Li Hongqing , Zhan Xiaoli , Gao Feng , Zhang Qinghua 
Published: January 2025

AbstractCritical issues such as leakage, degradation, and thermal response hysteresis have become the focus in the application of phase change materials (PCMs) in area such as thermal management of fabrics. The encapsulation of PCMs prepared as microcapsules using polysiloxanes, etc. as a component unit of crosslinking agents represents a highly promising avenue of research. In this work, organosilicon crosslinkers are prepared and employed for the crosslinking of poly (methyl methacrylate) (PMMA) for microencapsulation of paraffin wax in microcapsule phase change materials (mPCMs). The results showed that increasing the degree of crosslinking helps to improve the performance of mPCMs by smoothing the shell surface, but excessive crosslinking leads to flocculation, which reduces its performance. The mPCMs produced with 10% wt crosslinking agent gave the highest performance with encapsulation efficiency, melting enthalpy and crystallization enthalpy of 81.3%, 285.0 J g−1 and 253.1 J g−1, respectively. The obtained mPCMs are also combined with epoxy resin and fabrics to form composite materials. Notably, the polysiloxane‐modified mPCMs permit epoxy resins to achieve a maximum temperature reduction of 25 °C. By adjusting the mass ratio of organosilicon crosslinkers, the obtained mPCMs enable textiles to reach a maximum temperature reduction of 17 °C while maintaining satisfactory air permeability.
Recent Advances in Direct Synthesis of Functional Polymers of Intrinsic Microporosity Based on (Super)Acid Catalysis
Authors: Sun Xi , Zheng Jifu , Li Shenghai , Zhang Suobo 
Published: January 2025

AbstractPolymers of intrinsic microporosity (PIMs) are an emerging class of amorphous organic porous materials with solution processability, which are widely used in a multitude of fields such as gas separation, ion conduction, nanofiltration, etc. PIMs have adjustable pore structure and functional pore wall, so it can achieve selective sieving for specific substances. In order to meet the functional requirements of PIMs, two principal methods are used to synthesize functional PIMs, namely, post‐modification of PIMs precursors and functionalization of monomers. A number of post‐modification routes have been reported, however, the direct synthesis of functional PIMs with diverse groups still remains a challenge. The synthesis of PIMs through the acid‐catalyzed polyhydroxyalkylation has been demonstrated to be an effective solution, exhibiting the advantages of wider substrates range, milder reaction conditions, and higher molecular weight. Recently, a series of functional substrates for direct synthesis of PIMs have been proposed. This article presents a review and summary of recent advances in synthesizing PIMs via acid‐catalyzed polyhydroxyalkylation, and the synthesis route and structure‐activity relationship are emphasized, which provides a versatile platform for the direct synthesis of functional PIMs.
Hybrid Nanofibrous Membrane with Durable Electret for Anti‐Wetting Air Filtration
Authors: Yang Ming , Yao Ni , Surmenev Roman A. , Zhang Xinxin , Yu Jianyong , Zhang Shichao , Ding Bin 
Published: January 2025

AbstractElectrospun fibrous materials with fine fibers and small pores are fundamental for particulate matter (PM) filtration, addressing its harmful environmental and health impacts. However, the existing electrospun fibers are still limited to their sub‐micron diameters and unstable surface electrostatic effect, leading to deteriorated filtration performance after prolonged storage or wetting. Herein, the study creates nanofibrous membranes with long‐time stable electrostatics by electret‐enhanced electrospinning. The phase separation and polarization of the charged jet are manipulated to achieve rapid stretch and strong electret. The obtained membrane exhibits nanosized structures with fiber diameters of ≈220 nm, pore size <1 µm, as well as robust surface potential of 0.4 kV. By virtue of the synergistic effects of sieving and adsorption, the nanofibrous membrane showed a remarkable PM0.3 filtration efficiency of 96.6% and pressure drop of 140 Pa, even reaching the N90 standard after five wetting cycles. The design of such durable membranes will offer a new sight in the functional filtration materials.
Modeling absorbed alpha particle dose from diffusing alpha‐emitters radiation therapy in changing tissue volumes
Authors: Zhang Irene P. , Heger Guy , Cohen Gil'ad N. , Arazi Lior , Damato Antonio L. 
Published: January 2025

AbstractBackgroundDiffusing alpha‐emitters Radiation Therapy (“Alpha DaRT”) is a promising new radiation therapy modality for treating bulky tumors. 224Ra‐carrying sources are inserted intratumorally, producing a therapeutic alpha‐dose region with a total size of a few millimeter via the diffusive motion of 224Ra's alpha‐emitting daughters. Clinical studies of Alpha DaRT have reported 100% positive response (30%–100% shrinkage within several weeks), with post‐insertion swelling in close to half of the cases. While dosimetry recommendations informed by the effects of edema are standard in some radiation therapy modalities, the effect of edema and tumor shrinkage on the absorbed dose delivered by Alpha DaRT is still unknown.PurposeThe aim of this work is to develop a simple model for Alpha‐DaRT dose deposition in a time‐dependent tissue volume in order to study the effect of geometrical changes in source location due to edema and tumor shrinkage on the delivered alpha particle dose.MethodsWe perform FEM‐based dose deposition modeling for a single Alpha‐DaRT source inside shrinking and swelling tissues. Gradual volume change models were used for shrinkage and swelling, and an additional immediate volume gain model was also used for “worst case” swelling. Volume change rates were estimated from source location data from serial scans acquired at time of insertion and removal for seven patients treated using Alpha DaRT. We calculate absorbed dose profiles under both the high‐ and low‐diffusion regimes described by the Diffusion‐Leakage model.ResultsChanges in tissue volume can lead to over‐ or underestimation of the calculated absorbed dose. In the low‐diffusion regime, gradual tissue shrinkage can result in an increase of 100% and gradual swelling can result in a 35% decrease in absorbed dose compared to a calculation in static tissue. Although immediate post‐insertion swelling can reduce the absorbed dose by close to 65% for very closely spaced sources, in all cases analyzed the final absorbed dose continues to exceed the 10 Gy target. These effects are less severe in the high‐diffusion regime.ConclusionsThese results indicate that tissue swelling and shrinkage can have a non‐negligible effect on the tumor absorbed dose. Further study of tissue dynamics during Alpha‐DaRT treatment will be necessary for improvements in dosimetry practice.