bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased risk of reoperation and failure to attain clinically relevant improvement following autologous chondrocyte implantation of the knee in female patients and individuals with previous surgeries: a time‐to‐event analysis based on the German cartilage registry (KnorpelRegister DGOU)
Authors: Bumberger Alexander , Rupp Marco Christopher , Lattermann Christian , Kleiner Anne , Niemeyer Philipp 
Published: November 2023

AbstractPurposeThis study aimed to analyze the risk of reoperation following autologous chondrocyte implantation (ACI) of the knee utilizing third‐generation ACI products in a time‐to‐event analysis and report on the associated patient‐reported outcome measures (PROM) in case of reoperation.MethodsPatients undergoing ACI were included from a longitudinal database. Patient age, sex, body mass index (BMI), number of previous surgeries, lesion localization, lesion size, symptom duration, as well as time and type of reoperation was extracted. A cox proportional‐hazards model was applied to investigate the influence of baseline variables on risk of reoperation. Reoperation was defined as any type of subsequent ipsilateral knee surgery, excluding hardware removal. The Knee Injury and Osteoarthritis Outcome Score (KOOS) was utilized to compare PROM between patients with and without reoperation.ResultsA total of 2039 patients were included with 1359 (66.7%) having a minimum follow‐up of 24 months. There were overall 243 reoperations (prevalence 17.9%). Minor arthroscopic procedures (n = 96, 39.5%) and revision cartilage repair procedures (n = 78, 32.1%) were the most common reoperations. Nineteen patients (0.9%) reported conversion arthroplasty at 17.7 (10.4) months after ACI. Female sex (HR 1.5, 95% CI [1.2, 2.0], p = 0.002) and the presence of 1–2 previous surgeries (HR 1.5, 95% CI [1.1, 2.0], p = 0.010), or more than 2 previous surgeries (HR 1.9, 95% CI [1.2, 2.9], p = 0.004) were significantly associated with increased risk of reoperation following ACI. Significantly less patients surpassed the minimal clinically important difference (MCID) in the reoperation group at 24 months regarding the KOOS subscores pain (OR 1.6, 95% CI [1.1, 2.2]), quality of life (OR 2.2, 95% CI [1.6, 3.2]), symptoms (OR 2.0 [1.4, 2.9]), and sports (OR 2.0 [1.4, 2.8]).ConclusionFemale patients and individuals with a history of previous surgeries face an elevated risk of requiring reoperation after undergoing ACI, which is associated with failure to attain clinically relevant improvements. A thorough evaluation of the indications for ACI is paramount, particularly when patients have a history of previous surgeries.Level of evidenceLevel III.
The presence of a latent factor in gasoline and diesel prices co-movements
Authors: Magazzino Cosimo , Mele Marco , Albulescu Claudiu Tiberiu , Apergis Nicholas , Mutascu Mihai Ioan 
Published: November 2023

AbstractThis paper proposes a novel approach to identify the presence of a latent factor in the co-movements of gasoline and diesel prices in the three major European Union economies, (France, Germany, and Italy) using daily data from January 3, 2005, to June 28, 2021. More precisely, we advance an artificial neural networks algorithm estimated through a machine learning experiment through the backpropagation system to show that the neural signal is altered by an element that could coincide with a latent factor in the fuel price co-movements. We consider the role of the fuel tax systems and the connection between gasoline and diesel prices in these countries. The estimations indicate the presence of an unobservable component (the latent factor) in the fuel price co-movements, capable of influencing NN. This result validates the previous findings reported in the literature, indicating an excess co-movement in fuel prices. It also has implications in terms of fuel price forecasts in the short run.
Immunoregulatory role of hesperidin against ovalbumin (OVA)-induced bronchial asthma and depression in rats
Authors: Salama Abeer , Gouida Mona S. O. , Yassen Noha N. , Sedik Ahmed A. 
Published: November 2023

AbstractLinks between bronchial asthma and depression have recently become a great subject of interest. The present study was carried out to assess the protective role of hesperidin against ovalbumin (OVA)-induced bronchial asthma that is associated with depression in rats, for this purpose, four groups. Rats were sensitized with intraperitoneal administration of 200 μg OVA/10 mg aluminum hydroxide (Al (OH) 3 for 3 consecutive days then at day 11 followed by intranasal challenge with OVA (1.5 mg/kg) at days 19, 20, and 21. Rats were pretreated with hesperidin (100 & 200 mg/kg) 1h before OVA challenge. At the end of the study, behavioral tests, biochemical indices, and histopathological architectures of lung and brain tissues were evaluated. Our findings showed that hesperidin significantly ameliorated the reduction in motor activity, motor coordination, forced swimming, CD4, CD25 and foxp3, interleukin-10 (IL-10), dopamine, serotonin, and neurotrophin-3 (NT3) as well as alleviated the elevation in transforming growth factor-beta (TGF-β), tumor necrosis factor-alpha (TNF-α), iL-5, and immunoglobulin E (IgE). In addition, hesperidin reduced cellular infiltration, alveolar sacs damage, the bronchioles wall disruption, and nuclei pyknosis in neuron cells. Finally, hesperidin may provide protection against OVA-induced asthma and depression. This impact could be mediated in part by its anti-inflammatory and immunoregulatory properties.
Graphical abstract
How shoulder immobilization after surgery influences daily activity — a prospective pedometer-based study
Authors: Rickert Carolin , Ahlich Stefanie , Gosheger Georg , Kalisch Tobias , Liem Dennis , Schneider Kristian Nikolaus , Klingebiel Sebastian 
Published: November 2023

Abstract
Purpose
Immobilization, especially of the lower extremity, after orthopaedic surgery has been associated with reduced physical activity. Previous interventions from our study group showed even in young, healthy people reduced activity levels after immobilization of the shoulder. Therefore, this study investigates the change in physical activity due to shoulder immobilization after a reconstructive surgery.

Methods
This prospective study includes 40 patients undergoing surgery from May 2019 to December 2020. Daily activity was measured before surgery, after discharge and three weeks postoperatively each time for six days. Activity including step counts and active time were measured by Fitbit™ inspire. Range of motion before and after surgery as well as Pain (VAS) were documented.

Results
Steps became significantly less immediately postoperatively with an immobilized shoulder joint than before surgery (9728.8 vs. 6022.6, p < 0.05). At follow-up, the number of steps increased again, but still showed a significantly lower number of steps (mean 8833.2) compared to preoperative. Patients preoperatively showed mostly an “active” activity pattern, whereas postoperatively a “low active” behaviour predominated. The proportion of sedentary behaviour (“basal activity” and “limited activity”) was almost three times higher postoperatively (12.5% vs. 30%).

Conclusion
General physical activity is restricted during upper limb immobilization in adults. Therefore, activity-enhancing measures should be implemented in the early phase of rehabilitation after upper extremity surgery.
In-depth molecular analysis of lymphomas with lymphoplasmacytic differentiation may provide more precise diagnosis and rational treatment allocation
Authors: Brunner Andrea , Thalhammer-Thurner Gudrun Carolina , Willenbacher Wolfgang , Haun Margot , Zelger Bettina Gudrun , Willenbacher Ella 
Published: November 2023

AbstractWe performed a molecular analysis of formalin-fixed paraffin embedded and decalcified bone marrow trephine biopsies of 41 patients with a B-cell disorder with lymphoplasmacytic differentiation to enable a more precise diagnosis and to describe potentially prognostic and therapeutic relevant mutations. Analysis was performed with a commercially available next-generation sequencing (NGS) lymphoma panel (Lymphoma Solution, SophiaGenetics). Results were correlated with clinical and pathological parameters. Our group covered a spectrum of B-cell disorders with plasmacytic differentiation ranging from Waldenstroem’s macroglobulinemia (WM), to small-B-cell lymphomas with plasmacytic differentiation (SBCL-PC) to IgM myeloma (MM). The most helpful diagnostic criteria included morphology and immuno-phenotype as a prerequisite for the interpretation of molecular analysis. MYD88 mutation was present in nearly all WM, but also in 50% of SBCL-PCs, while MM were consistently negative. Driver mutations, such as TP53, were already detectable early in the course of the respective diseases indicating a higher risk of progression, transformation, and reduced progression-free survival. In addition, we report on a novel BIRC3 frameshift mutation in one case of a progressive WM. Our data indicate that patients with LPL/WM might benefit from thorough pathological work-up and detailed molecular analysis in terms of precise diagnosis and targeted treatment allocation.
Ex uno plures: how to construct high-speed movies of collapsing cavitation bubbles from a single image
Authors: Sieber Armand Baptiste , Preso Davide Bernardo , Farhat Mohamed 
Published: November 2023

AbstractThe time-resolved visualization of the dynamics of a cavitation bubble usually requires the use of expensive high-speed cameras, which often provide a limited spatial resolution. In the present study, we propose an alternative to these high-speed imaging techniques. The method is based on the recently introduced virtual frame technique, which relates the motion of a monotonic propagating front to the resulting image blur captured on a long-exposure shadowgraph. We use a consumer-level camera to photograph the entire collapse phase of cavitation bubbles. We then demonstrate that both the dynamics of a spherically collapsing bubble and those of a bubble collapsing near a rigid boundary can be accurately reconstructed from this single photograph at a virtual frame rate of up to 2 Mfps on a 24.2 Mpx sensor.
Dental age assessment in the living: a comparison of two common stage classifications for assessing radiographic visibility of the root canals in mandibular third molars
Authors: Timme Maximilian , Viktorov Jan , Steffens Laurin , Streeter Adam , Karch André , Schmeling Andreas 
Published: November 2023

AbstractAfter dentition is complete, degenerative tooth characteristics can be used for dental age assessment. Radiological assessment of the visibility of the root canals of the mandibular third molars in dental panoramic radiographs (DPRs) is known to be one such suitable feature. Essentially, two different stage classifications are available for evaluating the visibility of the root canals of mandibular third molars in the DPR. The aim of this study was to determine if one method outperforms the other. Therefore, the 2010 method of Olze et al. was directly compared to the 2017 method of Lucas et al. in the 2020 modification of Al Qattan et al. To this end, 233 DPRs from 116 females and 117 males aged 20.0 to 40.9 years were evaluated by three independent experienced examiners. In addition, one examiner ran two independent evaluations. Correlation between age and stage was investigated, and the inter- and intra-rater reliability was estimated for both methods. Correlation between age and stage was higher with the Olze method (Spearman rho 0.388 [95% CI 0.309, 0.462], males and 0.283 [95% CI 0.216, 0.357], females) than the Lucas method (0.212 [95% CI 0.141, 0.284], males and 0.265 [95% CI 0.193, 0.340], females). The intra-rater repeatability of the Olze method (Krippendorff’s α = 0.576 [95% CI 0.508, 0.644], males and α = 0.592 [95% CI 0.523, 0.661], females) was greater than that for the Lucas method (intra-rater α = 0.422 [95% CI 0.382, 0.502], males and α = 0.516 [95% CI 0.523, 0.661], females). Inter-rater reproducibility was also greater for the Olze method (α = 0.542 [95% CI 0.463, 0.620], males and α = 0.533 [95% CI 0.451, 0.615], females) compared to the Lucas method (α = 0.374 [95% CI 0.304, 0.443], males and α = 0.432 [95% CI 0.359, 0.505], females). The method of Olze et al. was found to present marginal advantages to the Lucas et al. method across all examinations and may be a more appropriate method for application in future studies.
Combined versus standalone XEN45 Gel Stent implantation in either phakic or pseudophakic patients: a case-matched study
Authors: Kiessling David , Rennings Corinna , Hild Matthias , Lappas Alexandra , Dietlein Thomas Stefan , Roessler Gernot Franz , Widder Randolf Alexander 
Published: November 2023

Abstract
Purpose
To determine differing outcomes among either phakic or pseudophakic patients who received standalone XEN45 Gel Stent (Allergan, an AbbVie Company, CA, USA) implantation and patients who underwent combined surgery with phacoemulsification.

Methods
This retrospective single-center study involved 180 eyes of 180 participants who underwent XEN45 Gel Stent implantation, of which 60 eyes received combined surgery with phacoemulsification (combined group). Standalone stent implantation was performed on 60 phakic (phakic group) and on 60 pseudophakic eyes (pseudophakic group). The groups were matched in a ratio of 1:1:1 based on multiple criteria. Successful surgery was defined by three scores: IOP at the longest follow-up of < 21 mmHg (Score A) or < 18 mmHg (Score B) and an IOP reduction > 20% or IOP ≤ 15 mmHg and an IOP reduction ≥ 40% (Score C). In all scores, one open conjunctival revision was allowed, and additional repeat surgery was considered a failure.

Results
After an average follow-up time interval of 20.6 ± 12.6 months, there was a mean IOP-reduction by 37% among the entire cohort. Comparative analysis between the three groups did not show significant differences regarding postoperative IOP, postoperative medication score, side effects, revision rate, repeat surgery rate or success rate. A dysfunctional stent was detected in eight eyes (4%) during open conjunctival revision in 76 eyes.

Conclusion
The clinical endpoints investigated did not differ significantly among either phakic or pseudophakic patients who received standalone stent implantation and patients who underwent combined surgery. However mean latency between primary stent implantation and first revision surgery after combined surgery was markedly shorter.
Interrupting sitting acutely attenuates cardiometabolic risk markers in South Asian adults living with overweight and obesity
Authors: Dey Kamalesh Chandra , Zakrzewski-Fruer Julia K. , Smith Lindsey R. , Jones Rebecca L. , Bailey Daniel P. 
Published: November 2023

Abstract
Purpose
This study examined the acute effects of interrupting sitting with light-intensity walking on postprandial cardiometabolic risk markers in South Asian adults.

Methods
South Asians with overweight/obesity (n = 19; body mass index [BMI] > 23 kg·m−2) and normal-weight (n = 8; BMI 18.0–22.9 kg·m−2) aged 48.8 ± 5.6 years completed two, 5-h conditions: (1) prolonged sitting (SIT), and (2) interrupted sitting with 5-min bouts of light-intensity walking every 30-min (INT-SIT). Blood samples and resting expired air samples were collected throughout each condition. Statistical analyses were completed using linear mixed models.

Results
In participants with overweight/obesity, postprandial glucose, triglycerides (TAG) and metabolic load index (MLI) over time were lower, whereas resting substrate utilisation and resting energy expenditure (REE) were higher, in INT-SIT than SIT (all p ≤ 0.05). Compared with SIT (0.18 [95% CI 0.13, 0.22] kcal.min−1), INT-SIT (0.23 [95% CI 0.18, 0.27] kcal.min−1) increased postprandial REE iAUC in participants with overweight/obesity (p = 0.04, d = 0.51). Postprandial TAG concentrations over time were lower in INT-SIT versus SIT (p = 0.01, d = 30) in normal-weight participants, with no differences in any other outcomes for this sample group.

Conclusion
These findings suggest that interrupting sitting with 5-min bouts of light walking every 30-min acutely attenuates cardiometabolic risk markers among South Asians living with overweight/obesity, whereas limited effects may be seen in individuals with normal-weight.
Barriers to the spiritual care of parents taking care of their child with a life-limiting condition at home
Authors: Brouwer Marije A. , Bas-Douw Barbara C. , Leget Carlo J. W. , Engel Marijanne , Teunissen Saskia C. C. M. , Kars Marijke C. 
Published: November 2023

AbstractThe changes that parents face when caring for a child with a life-limiting condition at home can affect them on a spiritual level. Yet, indications remain that parents do not feel supported when dealing with spiritual issues related to caring for a severely ill child. This paper explores, from the perspectives of bereaved parents, chaplains, grief counselors, and primary health care providers, the barriers to supporting the spiritual needs of parents. We conducted a qualitative focus group study from a constructivist point with chaplains/grief counselors, primary care professionals, and bereaved parents. All groups participated in two consecutive focus group sessions. Data were thematically analyzed. Six chaplains/grief counselors, 6 care professionals, and 5 parents participated. We identified six barriers: (1) There were difficulties in identifying and communicating spiritual care needs. (2) The action-oriented approach to health care hinders the identification of spiritual care needs. (3) There is an existing prejudice that spiritual care needs are by nature confrontational or difficult to address. (4) Spiritual support is not structurally embedded in palliative care. (5) There is a lack of knowledge and misconceptions about existing support. (6) Seeking out spiritual support is seen as too demanding.Conclusion: Parents of children with life-limiting conditions face existential challenges. However, care needs are often not identified, and existing support is not recognized as such. The main challenge is to provide care professionals and parents with the tools and terminology that suit existing care needs.

What is Known:• Spiritual care needs are an important aspect of pediatric palliative care.• Parents of children with life-limiting conditions feel unsupported when dealing with spiritual questions.

What is New:• Parents and professionals mention barriers that hinder spiritual support for parents.• There is a disconnect between existing support and the care needs that parents have.
The difference between port-Hamiltonian, passive and positive real descriptor systems
Authors: Cherifi Karim , Gernandt Hannes , Hinsen Dorothea 
Published: November 2023

AbstractThe relation between passive and positive real systems has been extensively studied in the literature. In this paper, we study their connection to the more recently used notion of port-Hamiltonian descriptor systems. It is well-known that port-Hamiltonian systems are passive and that passive systems are positive real. Hence it is studied under which assumptions the converse implications hold. Furthermore, the relationship between passivity and KYP inequalities is investigated.
Fluid effects in model granular flows
Authors: Zhao Yuting , Take W. Andy , Kaitna Roland , McArdell Brian W. , McElwaine Jim N. , Bowman Elisabeth T. 
Published: November 2023

AbstractPore fluid plays a crucial role in many granular flows, especially those in geophysical settings. However, the transition in behaviour between dry flows and fully saturated flows and the underlying physics that relate to this are poorly understood. In this paper, we report the results of small-scale flume experiments using monodisperse granular particles with varying water content and volume in which the basal pore pressure, total pressure, flow height and velocity profile were measured at a section. We compare the results with theoretical profiles for granular flow and with flow regimes based on dimensional analysis. The runout and the centre of mass were also calculated from the deposit surface profiles. As the initial water content by mass was increased from zero to around 10%, we first observed a drop in mobility by approximately 50%, as surface tension caused cohesive behaviour due to matric suction. As the water content was further increased up to 45%, the mobility also increased dramatically, with increased flow velocity up to 50%, increased runout distance up to 240% and reduced travel angle by up to 10° compared to the dry case. These effects can be directly related to the basal pore pressure, with both negative pressures and positive pore pressures being measured relative to atmospheric during the unsteady flow. We find that the initial flow volume plays a role in the development of relative pore pressure, such that, at a fixed relative water content, larger flows exhibit greater positive pore pressures, greater velocities and greater relative runout distances. This aligns with many other granular experiments and field observations. Our findings suggest that the fundamental role of the pore fluid is to reduce frictional contact forces between grains thus increasing flow velocity and bulk mobility. While this can occur by the development of excess pore pressure, it can also occur where the positive pore pressure is not in excess of hydrostatic, as shown here, since buoyancy and lubrication alone will reduce frictional forces.
Graphical abstract
Broaching Client Identities: Integrating a Critical Consciousness Lens in Counselling Practice
Authors: Barraclough Shanee , Malott Krista , Ahuriri-Driscoll Annabel 
Published: November 2023

AbstractCultural competence and, to a lesser extent, cultural safety for developing culturally responsive practice have been the dominant paradigms in the helping professions in Aotearoa New Zealand. This article focuses on a paradigm shift toward critical and structural consciousness in a masters-level counselling curriculum. Authors in this study undertook a qualitative inquiry in exploring counselling students’ experiences of a critically conscious curriculum, culminating in their application of the skill of broaching as a strategy for discussing client intersectional identities and structural and systemic issues. The students described experiences of discomfort, challenge, and transformative learning. Unique and nuanced challenges of learning broaching are delineated by the students. Findings suggest that learners must have complex understandings of critically conscious concepts and local dominant norms to effectively explore intersectional and marginalised identities with clients. Direction for educators and supervisors in ways to anticipate common challenges and to better train and supervise beginning counsellors in broaching are included.
The effects of high uncertainty risk on international stock markets
Authors: Aslanidis Nektarios , Christiansen Charlotte , P. Kouretas George 
Published: November 2023

AbstractWe conduct an international analysis of the cross-sectional risk premiums of uncertainty risk factors in addition to traditional risk factors. We consider international stock markets in five regions separately. We measure uncertainty by the local and US economic policy uncertainty indices. Economic policy uncertainty risk has negative risk premiums. This implies that investors get lower returns for assets with high uncertainty betas. We further analyze a nonlinear relationship between excess returns and uncertainty risk by adding the downside economic policy uncertainty risk factor which captures high levels of uncertainty, similar to downside market risk. The downside uncertainty risk factor has negative risk premiums.