bluuebunny/crossref_metadata_2025_split huggingface dataset:
A High‐Voltage Solid State Electrolyte Based on Spinel‐Like Chloride Made of Low‐Cost and Abundant Resources
Authors: Yu Yuran , Huang Yuanyuan , Xu Zibo , Wu Zhiheng , Wang Zhuo , Shao Guosheng 
Published: February 2024

AbstractRecently, halide solid state electrolytes (SSEs) have received great attention owing to their fast ionic conductivity, high oxidation potential, and good chemical and electrochemical compatibility with high voltage cathode materials. However, most of reported halide SSEs contain rather rare and expensive elements, which hinders their sustainable utilizations in practical batteries. Here in this work, under the guidance of systematic modelling based on the density functional theory (DFT), a low‐cost alternative is developed through optimizing the lattice chemistry in a recently identified spinel‐like chloride Li2CrCl4 into Li5/3Cr1/3Zr1/3Cl4 for remarkably enhanced ionic conductivity and stable electrochemical window with respect to the Li‐anode. This new phase has then been synthesized successfully, delivering an ionic conductivity over 1200 times of that of the pristine phase Li2CrCl4, in addition to a high oxidation potential (up to 4.1 V vs Li/Li+) to enable outstanding interfacial compatibility with high voltage cathodes. Such a high‐voltage and fast Li‐ion conducting solid‐state electrolyte is expected to provide a highly desirable basis toward developing high energy‐density all solid‐state batteries (ASSBs) using economical and Earth‐rich elements.
Peptide‐Driven Proton Sponge Nano‐Assembly for Imaging and Triggering Lysosome‐Regulated Immunogenic Cancer Cell Death
Authors: He Tengyu , Wen Jing , Wang Wenjian , Hu Zeliang , Ling Chuxuan , Zhao Zhongchao , Cheng Yong , Chang Yu‐Ci , Xu Ming , Jin Zhicheng , Amer Lubna , Sasi Lekshmi , Fu Lei , Steinmetz Nicole F. , Rana Tariq M. , Wu Peng , Jokerst Jesse V. 
Published: February 2024

AbstractTriggering lysosome‐regulated immunogenic cell death (ICD, e.g., pyroptosis and necroptosis) with nanomedicines is an emerging approach for turning an “immune‐cold” tumor “hot”—a key challenge faced by cancer immunotherapies. Proton sponge such as high‐molecular‐weight branched polyethylenimine (PEI) is excellent at rupturing lysosomes, but its therapeutic application is hindered by uncontrollable toxicity due to fixed charge density and poor understanding of resulted cell death mechanism. Here, a series of proton sponge nano‐assemblies (PSNAs) with self‐assembly controllable surface charge density and cell cytotoxicity are created. Such PSNAs are constructed via low‐molecular‐weight branched PEI covalently bound to self‐assembling peptides carrying tetraphenylethene pyridinium (PyTPE, an aggregation‐induced emission‐based luminogen). Assembly of PEI assisted by the self‐assembling peptide‐PyTPE leads to enhanced surface positive charges and cell cytotoxicity of PSNA. The self‐assembly tendency of PSNAs is further optimized by tuning hydrophilic and hydrophobic components within the peptide, thus resulting in the PSNA with the highest fluorescence, positive surface charge density, cell uptake, and cancer cell cytotoxicity. Systematic cell death mechanistic studies reveal that the lysosome rupturing‐regulated pyroptosis and necroptosis are at least two causes of cell death. Tumor cells undergoing PSNA‐triggered ICD activate immune cells, suggesting the great potential of PSNAs to trigger anticancer immunity.
Skin‐Inspired Multi‐Modal Mechanoreceptors for Dynamic Haptic Exploration
Authors: Su Jiangtao , Zhang Hang , Li Haicheng , He Ke , Tu Jiaqi , Zhang Feilong , Liu Zhihua , Lv Zhisheng , Cui Zequn , Li Yanzhen , Li Jiaofu , Tang Leng Ze , Chen Xiaodong 
Published: February 2024

AbstractActive sensing is a fundamental aspect of human and animal interactions with the environment, providing essential information about the hardness, texture, and tackiness of objects. This ability stems from the presence of diverse mechanoreceptors in the skin, capable of detecting a wide range of stimuli and from the sensorimotor control of biological mechanisms. In contrast, existing tactile sensors for robotic applications typically excel in identifying only limited types of information, lacking the versatility of biological mechanoreceptors and the requisite sensing strategies to extract tactile information proactively. Here, inspired by human haptic perception, a skin‐inspired artificial 3D mechanoreceptor (SENS) capable of detecting multiple mechanical stimuli is developed to bridge sensing and action in a closed‐loop sensorimotor system for dynamic haptic exploration. A tensor‐based non‐linear theoretical model is established to characterize the 3D deformation (e.g., tensile, compressive, and shear deformation) of SENS, providing guidance for the design and optimization of multimode sensing properties with high fidelity. Based on SENS, a closed‐loop robotic system capable of recognizing objects with improved accuracy (≈96%) is further demonstrated. This dynamic haptic exploration approach shows promise for a wide range of applications such as autonomous learning, healthcare, and space and deep‐sea exploration.
Engineered Bio‐Based Hydrogels for Cancer Immunotherapy
Authors: Peng Yuxuan , Liang Shuang , Meng Qian‐Fang , Liu Dan , Ma Kongshuo , Zhou Mengli , Yun Kaiqing , Rao Lang , Wang Zhaohui 
Published: February 2024

AbstractImmunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy and severe immune‐related side effects are frequently encountered, especially in solid tumors. Hydrogels, a class of versatile materials featuring well‐hydrated structures widely used in biomedicine, offer a promising platform for encapsulating and releasing small molecule drugs, biomacromolecules, and cells in a controlled manner. Immunomodulatory hydrogels present a unique capability for augmenting immune activation and mitigating systemic toxicity through encapsulation of multiple components and localized administration. Notably, hydrogels based on biopolymers have gained significant interest owing to their biocompatibility, environmental friendliness, and ease of production. This review delves into the recent advances in bio‐based hydrogels in cancer immunotherapy and synergistic combinatorial approaches, highlighting their diverse applications. It is anticipated that this review will guide the rational design of hydrogels in the field of cancer immunotherapy, fostering clinical translation and ultimately benefiting patients.
Conformal Broad‐Spectra Laser Sensing Array from Ferroelectric Polymer Composites
Authors: Fu Mengyuan , Guo Mengfan , Yang Minzheng , Zhou Le , Shen Yang 
Published: February 2024

AbstractPhotoelectric sensors based on charge‐coupled device (CCD) and complementary‐metal‐oxide‐semiconductor (CMOS) used to be planar image sensors due to the rigidity of the base materials. Moreover, they are limited to a narrow reaction wavelength range. Here, a conformal broad‐spectra laser sensor based on a flexible metal‐ferroelectric‐metal photocapacitor is promoted. The photocapacitance signal is attributed to the photothermal effect of copper (Cu) electrode and gold nanoparticles (Au NP), and the temperature‐dependent property of the dielectric constant of poly(vinylidene fluoride‐trifluoroethylene) (PVDF‐TrFE). Cu/PVDF‐TrFE/Cu and Cu/Au NP@PVDF‐TrFE/Cu flexible photocapacitors have a reliable photocapacitive response from −60 to 60 °C. Meanwhile, both photocapacitors respond from 265 to 980 nm due to the absorption of light by the composite structure, which can be used for broad‐spectra photodetection. The addition of a small amount of Au NP (0.05 vol%) effectively improves the photoresponsiveness of the device. Real‐time photodetection is realized on a hemispherical surface, and these photocapacitors with conformal characteristics are expected to gain application in an omnidirectional broad‐spectra laser alarming system.
Porous Silicon Nanoparticles Conjugated Magnetite‐Chitosan Graphene Oxide Nanoparticles for Effective Removal of Complex Pollutants
Authors: Qu Xiangmeng , Zhang Hongbo , Kong Haixin , Chen Dong , Yang Zhou , Mäkilä Ermei , Salonen Jarno , Santos Hélder A. , Hai Mingtan , Weitz David A. 
Published: February 2024

AbstractThe effective removal of complex pollutants is extremely challenging for environmental and material science, especially pollutants including detergents and pesticides do not decompose or degrade in the aquatic environment which cannot be easily removed. Here, a novel biocompatible superparamagnetic nanocomposite integrating the advantages of porous silicon nanoparticles is developed, the chelation ability of chitosan, and graphene‐oxide‐iron that can simultaneously adsorb complex hydrophobic and hydrophilic pollutants on their internal and external surfaces which have significantly improved pollutant removal efficiency over the current existing methods. A porous silicon nanoparticle (PSi) conjugated magnetite‐chitosan‐reduced graphene oxide (MCRGO) nanoparticles (PSi‐MCRGO) are synthesized for complete removal of detergent, pesticide, and toxic heavy metals cadmium and lead ions from water at a favorable room temperature. The adsorption behavior of the nanocomposites fits well with the Freundlich isotherm and pseudo‐second‐order kinetics model by adsorption mechanism. Moreover, the fresh and recycled nanocomposites are easily separated by an external magnetic field for reusability due to super magnetite response and show high binding capacity for toxic heavy metal ions. Furthermore, the nanocomposites are biocompatible and reusable, and for the fourth time, recycled nanocomposites can completely remove toxic heavy metals. Overall, the novel nanocomposites completely remove complex pollutants which hold great potential for real water treatment.
Exploration of Electrode‐Electrolyte‐in‐One System Based on Fluorine/Chloride Ion Battery
Authors: Wu Mengqi , Hu Xuechen , Cui Fuhan , Wang Jianglong , Zhao Chunyu , Shi Xingqiang , Liu Huanjuan , Wang Ruining , Zhang Hu , Jin Chendong , Gong Penglai , Cai Dong , Wei Yingjin , Lian Ruqian 
Published: February 2024

AbstractWith an increasingly profound understanding of battery materials, strategies designed for interface protection have become more sophisticated. However, it is inherent that different materials used in electrodes and electrolytes tend to react with each other. To address this issue, this study proposes an “Electrode‐Electrolyte‐In‐One” (EEIO) concept, where a single energy storage material can serve as both electrode and solid‐state electrolyte (SSE) during its different ion storage stages. The EEIO materials of chloride ion batteries and fluorine ion batteries are preliminarily studied, establishing reasonable screening procedures and predicting their operational mechanisms. The analysis of Cl− and F− affinity indicates that the EEIO system in the anion storage batteries comprises the anode and SSE. Through comprehensive evaluation of ion binding capacity, phase transformation mechanism, electrical conductivity, and ion diffusion kinetic properties, several potential EEIO materials are identified. In the EEIO system, the material interface and the conductive‐insulation interface are separated, which solves the material compatibility problem between the anode and SSE. Furthermore, the EEIO system has an inherent correlation between the anode electrochemical reaction and the SSE decomposition reaction, ensuring that the electrochemical voltage of EEIO batteries never exceeds the decomposition voltage of SSE. Therefore, SSE in the EEIO battery has absolute electrochemical stability.
Nitrogen fertilizer source, rate, placement, and application timing effect on sorghum (grain and forage) and corn grain yields
Authors: Holman Johnathan D. , Ruiz Diaz Dorivar A. , Obour Augustine K. , Assefa Yared 
Published: February 2024

AbstractIdentifying the limiting nutrient, fertilizer source, rate, placement, additives, and timing of application are critical components of fertilizer management. The objective of this study was to quantify the impact of nitrogen (N) fertilizer source, rate, placement method, additives, application timing, and environment on yields of grain sorghum, forage sorghum [Sorghum bicolor (L.) Moench], and corn (for grain, Zea mays L.). Independent field experiments were conducted at 13 different environments in Kansas from 2008 through 2013 on grain sorghum, forage sorghum, and corn. Treatments were an incomplete factorial combination of four fertilizer placement methods, three fertilizer types, five fertilizer additives, three fertilizer application times, and six fertilizer rates that varied by location and across years. Results showed grain and forage sorghum yields responded to N fertilizer in environments that were not extremely dry (<136 mm) or wet (>651 mm). Corn responded to N fertilizer application only in high‐precipitation environments. For grain sorghum, where rate × placement × source × additive interaction was significant, broadcast application of urea (source) at high rates (67–134 kg N ha−1), with summer application timing, or with additive in winter (with environmentally smart nitrogen [ESN]) resulted in up to 43% greater yield compared with application of urea‐ammonium nitrate (UAN; source) and surface band (placement) at 67 kg ha−1 without additives. In the one site‐year where forage sorghum responded to fertilizer application, forage yields with preplant application of UAN at 56–140 kg ha−1 were 164% greater than the control. For corn, application of either urea or UAN fertilizer, UAN in coulter or surface band, with ESN blend, applied at planting, and at highest rates (160 kg ha−1) resulted in best yields compared with the alternatives and 110% greater yield compared with the unfertilized control. We concluded that fertilizer rate is an important management component as it consistently affected yield regardless of crop considered. Fertilizer placement and timing have crop‐specific importance as they were significant for only corn, but the main effect of additives (N stabilizers) was not significant for any of the crops. Environment and crop type influenced crop response to N fertilizer rate, timing, placement, and additives.
Development of a gridded yield data archive for farm management and research at the USDA Beltsville Agricultural Research Center
Authors: Dulaney Wayne P. , Anderson Martha C. , Gao Feng , Stern Alan , Moglen Glenn , Meyers George , Daughtry Craig S. T. , White William , Akumaga Uvirkaa , Showalter Jennifer 
Published: February 2024

AbstractHigh‐quality, gridded maps of crop yield, which discern the spatial variability in productivity across individual farm fields, are extremely valuable in numerous agricultural and remote sensing applications. The availability of these data was greatly facilitated by the development and adoption of grain yield monitors starting in the early 1990s. However, the utility of raw yield monitor data is limited if additional processing has not been carried out to ensure data quality. In addition, a readily accessible data repository that allows for examining long‐term yield variability in response to climate and management is often not available. We present a protocol for producing a multi‐year (7 years currently processed), gridded yield data archive derived from yield monitor data acquired from over 40 production fields at the Beltsville Agricultural Research Center (BARC) in Beltsville, MD. Production of the archive involved the projection of the yield monitor data into a geographic coordinate system suitable for mapping, the identification and removal of data outliers, and the production of gridded, spatially interpolated yield maps using block Kriging. All map products were produced in common, nonproprietary file formats for easy access. Preliminary assessments of the processed yield monitor data have underscored the necessity of data filtering and have shown the influence of previous land use practices and biophysical properties, such as topography and soil moisture availability, on yield response. We discuss the use of spatially interpolated, archival yield maps in the implementation of precision farming techniques such as the development of site‐specific variable rate prescriptions as well as remote sensing applications, including the selection of field sites for long‐term agricultural experiments and the assessment of crop modeling approaches. The gridded yield data archive will be housed at the National Agricultural Library as a dynamic dataset that will continue to expand in breadth and depth. It will be a part of and provide support to internal USDA yield monitoring investigations as well as complementary external efforts. All geospatial data delivered to NAL will adhere to the ISO 19115 Geospatial Metadata Standards to provide the user with a full understanding of the yield monitor and associated datasets.
Nitrogen application and cultivar effects on industrial hemp yield dynamics
Authors: Kaur Navdeep , Griffin Winnifred , Sandhu Amanpreet , Sidhu Simranpreet , Brym Zack , Sharma Lakesh 
Published: February 2024

AbstractRenewed interest in hemp (Cannabis sativa L., <0.3% delta‐9‐tetrahydrocannabinol) production has motivated investigations into crop management and fertilizer application. Due to fertilizer regulations, soil characteristics, and unique climatic conditions in Florida, researching nutrient management for region‐specific hemp cultivation is essential. A study conducted in central Florida during 2021 and 2022 used six nitrogen (N) rates (0, 56, 112, 168, 224, and 280 kg ha−1) and five cultivars (NWG‐2730, X‐59, Bialobrzeskie, IH Williams, and Yuma) as a first effort to develop producer‐oriented fertilizer guidelines. The field experiments employed a randomized complete block design across N rates and varieties, with N applied in three split applications. The results indicated an interaction between cultivars and N rates, as expected due to their diverse genetic and geographic origins. Challenges in genetic and germination quality resulted in grain and biomass yield of two cultivars, X‐59 and Bialobrzeskie, that did not respond to the N application. Conversely, NWG‐2730, IH Williams, and Yuma cultivars demonstrated significantly higher yields within the 168–280 kg ha−1 N range. Moreover, cultivars demonstrated differing emergence counts (field count), and findings indicated a correlation between emergence and plant count at harvest (r = 0.68 and p = 0). The study also found a difference in germination count versus field count (after adjusting the seed rate depending on germination percentage). Enhanced plant count at harvest substantially elevated grain and biomass yield. The N application positively influenced plant height across all cultivars except Bialobrzeskie. Optimal plant height was achieved within the 168–280 kg N ha−1 range. Therefore, optimizing N rates and selecting cultivars (with higher emergence rates in the field) could help achieve higher biomass and grain yields.
Development of a new cerebral ischemia reperfusion model of Mongolian gerbils and standardized evaluation system
Authors: Wu Ying , Hu Caijiao , Li Zhihui , Li Feiyang , Lv Jianyi , Guo Meng , Liu Xin , Li Changlong , Huo Xueyun , Chen Zhenwen , Yang Lifeng , Du Xiaoyan 
Published: February 2024

AbstractBackgroundThe Mongolian gerbil is an excellent laboratory animal for preparing the cerebral ischemia model due to its inherent deficiency in the circle of Willis. However, the low incidence and unpredictability of symptoms are caused by numerous complex variant types of the circle. Additionally, the lack of an evaluation system for the cerebral ischemia/reperfusion (I/R) model of gerbils has shackled the application of this model.MethodsWe created a symptom‐oriented principle and detailed neurobehavioral scoring criteria. At different time points of reperfusion, we analyzed the alteration in locomotion by rotarod test and grip force score, infarct volume by triphenyltetrazolium chloride (TTC) staining, neuron loss using Nissl staining, and histological characteristics using hematoxylin–eosin (H&E) straining.ResultsWith a successful model rate of 56%, 32 of the 57 gerbils operated by our method harbored typical features of cerebral I/R injury, and the mortality rate in the male gerbils was significantly higher than that in the female gerbils. The successfully prepared I/R gerbils demonstrated a significant reduction in motility and grip strength at 1 day after reperfusion; formed obvious infarction; exhibited typical pathological features, such as tissue edema, neuronal atrophy and death, and vacuolated structures; and were partially recovered with the extension of reperfusion time.ConclusionThis study developed a new method for the unilateral common carotid artery ligation I/R model of gerbil and established a standardized evaluation system for this model, which could provide a new cerebral I/R model of gerbils with more practical applications.
Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets
Authors: Cheng Lianying , Rong Xiaofeng 
Published: February 2024

AbstractBackgroundTo study the relationships among emodin, synovial fibroblasts (FLSs), and macrophages (STMs) to provide guidance for the use of emodin in rheumatoid arthritis (RA) treatment.MethodsRA clinical samples from patients with different pathological processes were collected, and the correlations between the subsets of FLSs and STMs and pathological processes were analyzed via flow cytometry. In vitro experimental methods such as enzyme linked immunosorbent assay (ELISA), Western blotting, Transwell assays, CCK‐8 assays and cell coculture were used to assess cell proliferation, migration and secretion of inflammatory factors. A collagen‐induced arthritis mouse model was constructed to investigate the therapeutic potential of emodin in RA by flow cytometry, micro‐CT and staining.ResultsUnique subsets of FLSs and STMs, namely, FAPα+THY1− FLSs, FAPα+THY1+ FLSs, and MerTKposTREM2high STMs, were identified in synovial tissues from RA patients. The number of MerTKposTREM2high STMs was negatively correlated with the degree of damage in RA, while the number of FAPα+THY1− FLSs was positively correlated with damage. On the one hand, emodin promoted the aggregation of MerTKposTREM2high STMs. Moreover, MerTKposTREM2high STM‐mediated secretion of exosomes was promoted, which can inhibit the secretion of pro‐inflammatory factors by FAPα+THY1+ FLSs and promote the secretion of anti‐inflammatory factors by FAPα+THY1+ FLSs, thereby inhibiting FAPα+THY1−FLS proliferation and migration, improving the local immune microenvironment, and inhibiting RA damage.ConclusionEmodin was shown to regulate the aggregation of STM subsets and exosome secretion, affecting the secretion, proliferation and migration of inflammatory factors in FLS subsets, and ultimately achieving good therapeutic efficacy in RA patients, suggesting that it has important clinical value.