bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of primary organ site of involvement by peripheral T‐cell lymphoma not otherwise specified on survival
Authors: Davis Olivia , Truong Derek , Day Silas , Pandey Manu , Ibrahimi Sami , Khawandanah Mohamad , Holter‐Chakrabarty Jennifer , Asch Adam , Al‐Juhaishi Taha 
Published: December 2023

AbstractIntroductionPeripheral T‐cell lymphoma, not otherwise specified (PTCL‐NOS) is a rare, highly heterogeneous group of mature T‐cell neoplasms that historically has been associated with poor outcomes. We sought to investigate the influence of primary disease site on PTCL‐NOS outcomes using a large national cancer registry.MethodsBaseline clinical and demographic data including primary organ of involvement and Ann Arbor disease stage were extracted from the SEER database. Patients were grouped into nine organ system groups and compared to nodal disease acting as a control. Cox regression models were utilized for adjusted survival analyses.ResultsA total of 3095 patients were identified in the SEER database and included in the final analysis. The median age was 61 and a majority of patients were male (60%) and identified as non‐Hispanic white (68%). A plurality of patients had stage IV disease (32%). Lymph nodes and spleen were the most common primary disease sites (67%), while central nervous system was the least common (1%). Patients with early‐stage PTCL‐NOS of the gastrointestinal/genitourinary systems had worse overall survival [HR = 1.97 (1.50–2.59); p < 0.001] and lymphoma‐specific survival [HR = 1.74 (1.26–2.40); p < 0.001] which was statistically significant even after adjusting for other variables. Early‐stage PTCL‐NOS of the central nervous system also had worse overall survival [HR = 1.90 (1.11–3.27); p = 0.020] and lymphoma‐specific survival [HR = 2.11 (1.17–3.80); p = 0.013]. Early‐stage PTCL‐NOS of the skin had better overall survival [HR = 0.54 (0.42–0.68); p < 0.001] and lymphoma‐specific survival [HR = 0.388 (0.28–0.53); p < 0.001] which was statistically significant even after adjustments.ConclusionOur findings suggest an association between primary organ involved by PTCL‐NOS and both overall and lymphoma‐specific survival even after adjusting for common variables. These results warrant validation in future prospective studies.
Can augmented reality impact your self‐perceptions? The malleability of the self and brand relationships in augmented reality try‐on services
Authors: Kim Terry Haekyung , Im Hyunjoo 
Published: December 2023

AbstractBrands and retailers are eager to utilize augmented reality (AR) technology to engage consumers and develop favorable relationships with them. However, there is a need for a theoretical understanding of the assumed AR effect. This study aims to identify an underlying mechanism of the AR (vs. typical online website) effects by focusing on consumers' perception of malleable self‐concept, which refers to the changeable nature of the self‐concept. The findings of two experiments demonstrate that AR, when compared to a typical online website without AR function, increases self‐brand connection through enhanced imagery and beliefs on the malleability of the self. The improved self‐brand connection further heightens marketing outcomes, such as revisit intention to the website. The AR effect is qualified by consumers' virtual self‐discrepancy, suggesting an important implication for brand management. This research offers new insights into the role of AR interface in consumer‐brand relationships and highlights the impact of AR on consumer's self‐perception. Innovative marketers and brands are likely to benefit from this study in improving their relationship with consumers by utilizing emerging digital retail environments.
Characterization of the interactions between Fulvic acid and Trypsin with Spectroscopic and Molecular Docking technology
Authors: Sun Jisheng , Wang Xiaoxia , Nie Zhihua , Ma Litong , Sai Huazheng , Cheng Jianguo , Liu Yunying , Duan Jianguo 
Published: December 2023

AbstractThe interaction mechanism between trypsin and fulvic acid was analyzed by multispectral method and molecular docking simulation. The fluorescence spectra showed that fulvic acid induced static quenching of trypsin. The validity of this conclusion was further substantiated through the computation of the binding constants. The thermodynamic parameters show that the reaction is mainly controlled by van der Waals force and hydrogen bond force, and the reaction is spontaneous. In addition, based on the obtained binding distance, there may be a non‐radiative energy transfer between the two. The ultraviolet spectrum showed that fulvic acid could shift the absorption peak of trypsin, indicating that fulvic acid had an effect on the secondary structure of trypsin. According to the synchronous fluorescence spectrum results, fulvic acid primarily interacts with tryptophan residues in trypsin and induces alterations in their microenvironment. Three‐dimensional fluorescence spectrum and circular dichroism further proves this conclusion. The molecular docking simulation reveals that the interaction between the two groups primarily arises from hydrogen bonding and van der Waals forces. The findings suggest that FA has the ability to induce conformational changes in trypsin‘s secondary structure.
In Silico Exploration of Potential Phytoconstituents from the Bark Extract of Boswellia serrata for Hemorrhoidal Disease: Molecular Docking and Molecular Dynamics Analysis**
Authors: Rao Harshawardhan , Maurya Aryan , Kumar Raidas Hemant , Koram Bholeshankar , Kumar Goswami Rohit , Singh Rajpoot Vivek , Khute Sulekha , Subash Paranthaman , Chandra Mandal Subhash , Saha Subham , Rao Kareti Srinivasa 
Published: December 2023

AbstractBoswellia serrata Roxb. Ex Colebr is a popular medicinal plant used traditionally in herbal medicinal preparations to treat a variety of diseases. The purpose of the present investigation was to investigate the anti‐hemorrhoidal property of the bark extract of B. serrata (BS). For this, the sequential Soxhlet extraction method was carried out by using different solvents such as hexane, chloroform, and methanol. After the extraction, the obtained dry extracts were tested for quantitative determinations such as total alkaloid content (TAC), total flavonoid content (TFC), total phenol content (TPC), and total tannin content (TTC) for all the extracts. Moreover, in vitro antioxidant activity was measured using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical scavenging activity and scavenging activity against 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS). Methanolic bark extract showed the highest TPC (67.10±1.83), TFC (372.73±4.45), TAC (9.732±1.06), and TTC (48.932±1.82), as well as the antioxidant assays DPPH (IC50=9.88 μg/ml) and ABTS (IC50=15.09 μg/ml). In this study, both LC–MS and GC–MS were performed to identify the chemical composition of all the extracts. Consequently, 19 compounds were identified by GC–MS and 27 compounds were identified by LC–MS analysis. The identified phytoconstituent(s) that could potentially interact with the target protein cyclooxygenase‐2 (COX‐2) (PDB: 4RRW) using molecular dynamics simulation and in silico docking were studied. Three compounds that have passed in drug‐likeness and ADME‐Tox properties are having more docking score than the standard. In this study, camptothecin, justicidin B, and taxiphyllin are identified as potential lead compounds with anti‐hemorrhoidal properties and may be helpful in the process of drug development and discovery of novel drugs. Hence, these results demonstrate that BS is a good source of pharmacologically active components with potential applications against hemorrhoidal disease.
Experiments on and Simulations of Hollow Cylinders Falling through Quiescent Liquids
Authors: Lu Menghua , Zhang Lijuan , Li Jiayi , Lu Jie , Liu Fengjiao , Derksen Jos J. 
Published: December 2023

AbstractQuantitative visualization experiments of hollow cylinders falling through a Newtonian liquid were performed. The Archimedes number was in the range 5 to 105, the length/outer diameter ratio of the cylinders was in the range 2.5–10, and the inner/outer diameter ratio was 0–0.85. The definition of the Archimedes number includes the inner and outer cylinder diameters, and it is shown that cylinders with the same Archimedes number having different diameter ratios behave similarly. Particle‐resolved simulations were used to enhance the insight into the fluid flow generated by the settling cylinder. They were also used to assess the flow through a hollow cylinder during settling.
Covalent Organic Frameworks: Cutting‐Edge Materials for Carbon Dioxide Capture and Water Harvesting from Air
Authors: Mabuchi Haruna , Irie Tsukasa , Sakai Jin , Das Saikat , Negishi Yuichi 
Published: December 2023

AbstractThe implacable rise of carbon dioxide (CO2) concentration in the atmosphere and acute water stress are one of the central challenges of our time. Present‐day chemistry is strongly inclined towards more sustainable solutions. Covalent organic frameworks (COFs), attributable to their structural designability with atomic precision, functionalizable chemical environment and robust extended architectures, have demonstrated promising performances in CO2 trapping and water harvesting from air. In this Review, we discuss the major developments in this field as well as sketch out the opportunities and shortcomings that remain over large‐scale COF synthesis, device engineering, and long‐term performance in real environments.
Recent Progress in Synthesis and Application of Chiral Organoselenium Compounds
Authors: Lai Shuyan , Liang Xiayu , Zeng Qingle 
Published: December 2023

AbstractChiral organoselenium compounds have shown an important role as intermediates in many areas, such as drug discovery, organic catalysis, and nanomaterials. A lot of different methods have been developed to synthesize chiral compounds which contain selenium, because they have interesting properties and can be used in real life. Over the last few decades, a lot of progress has been made in synthesizing chiral organoselenium compounds. This work gives an overview of the progress made in creating new ways to synthesize chiral organoselenium compounds by categorizing them into groups based on the reactions they undergo. In addition, the use of chiral organoselenium compounds is also discussed.
The cilium like region of the Drosophila bifurca spermatocyte: Elongation of a giant axoneme without intraflagellar transport
Authors: Riparbelli Maria Giovanna , Pratelli Ambra , Callaini Giuliano 
Published: December 2023

AbstractThe growth of the ciliary axonemes mainly depends on the evolutionary conserved intraflagellar transport (IFT) machinery. However, insect spermatocytes are characterized by cilium‐like regions (CLRs) that elongate in the absence of IFT. It is generally believed that the dynamics of these structures relies on the free diffusion of soluble tubulin from the cytoplasm. However, this passive process could allow the elongation of short ciliary axonemes, but it is unclear whether simple diffusion of tubulin molecules can ensure the correct assembly of elongated ciliary structures. To decipher this point we analyzed the assembly of the CLRs held by the primary spermatocytes of Drosophila bifurca. These ciliary structures consist of a very elongated axoneme that grows without IFT and, therefore, could represent a good model in which to evaluate the role played by the free diffusion of soluble tubulin. The observation of wavy microtubules in the axonemal lumen of fully elongated CLRs of D. bifurca may be consistent with the diffusion of tubulin within the axonemal lumen. Progressive consumption of soluble tubulin used for axoneme growth at the apical tip of the CLRs could result in a gradient sufficient to move tubulin from the cytoplasm to the apical end of the forming ciliary structure. When the axoneme reaches its full length, tubulin molecules are not drawn to the tip of the CLRs and accumulate at the base of the axoneme, where its concentration may exceed the threshold need for microtubule polymerization. The presence of γ‐TuRCs at the proximal ends of the supernumerary microtubules could enhance their nucleation.
A multicenter retrospective analysis: Factors influencing hepatic adverse events induced by immunotherapy in advanced liver cancer
Authors: Zou Rui , Hao Yunhe , Wang Yiyao , Yan Feihu , Peng Xu , Huang Zepeng , Chen Gang 
Published: December 2023

AbstractObjectivesTo analyze the clinical characteristics and influencing factors of hepatotoxicity in patients with advanced hepatocellular carcinoma (HCC) treated with programmed cell death protein‐1 (PD‐1) inhibitors, and to provide a theoretical basis for the treatment of immune‐related hepatotoxicity in patients with advanced HCC.MethodsRetrospective analysis of clinical data of patients with advanced HCC from February 2021 to February 2023, in order to summarize and statistically analyze the influencing factors of immune‐related liver adverse reactions.ResultsA total of 135 patients met the inclusion criteria, among whom 46 patients experienced varying degrees of immune‐related liver adverse reactions, with an incidence rate of 34.1% (46/135). The time range of immune‐related liver adverse reactions was 3–26 weeks, with a median time of 4 weeks. The age range of immune‐related liver adverse reactions was 34–73 years, with a median age of 62 years. Statistical analysis of the influencing factors and liver adverse reactions showed that age, total bilirubin level, and Child–Pugh (C–P) grading were influencing factors for the occurrence of liver adverse reactions (p < .05), and among these three influencing factors, the proportion of males with ≥2 influencing factors was higher than that of females; liver function C–P B was an independent influencing factor for liver adverse reactions (p < .05).ConclusionFor male patients over 60 years old, with bilirubin levels ≥51 μmol/L and liver function C–P B, close observation of the occurrence of immune‐related adverse reactions during treatment is recommended.
Hybrid interleaved DC‐DC step‐up converter based on coupled inductor
Authors: Alizadeh Darioush , Babaei Ebrahim , Sabahi Mehran , Cecati Carlo 
Published: December 2023

SummaryIn this paper, a high voltage gain hybrid interleaved DC‐DC converter (HIC) with quadratic voltage gain is proposed that is suitable for renewable energy systems. The hybrid technique is used in this converter to increase the output voltage. The proposed DC‐DC converter utilizes the interleaved boost converter on the input side, and the input current is shared with a low ripple that lengthens the lifetime of the renewable power source. In addition, the proposed converter has low voltage stress across the components that can be adopted to reduce conduction losses and the cost of the elements. In addition, the proposed converter share ground between the input and output and has high efficiency. The operation modes of the proposed converter are analyzed, and its equations are calculated. Then, the elements of the proposed converter are designed in continuous conduction mode. A comprehensive comparison of the proposed converter with other recently presented existing converters is discussed to show the advantages and disadvantages of the proposed structure. Finally, to verify the performance of the proposed converter and the obtained relations, a 400 W prototype is built to demonstrate the effectiveness of the proposed converter.
Behavioral responses to natural rewards in developing male and female rats
Authors: Oak Sasha , Nguyen Christine , Rodney‐Hernández Paolaenid , Rincón‐Cortés Millie 
Published: December 2023

AbstractReward deficits are a hallmark feature of multiple psychiatric disorders and often recapitulated in rodent models useful for the study of psychiatric disorders, including those employing early life stress. Moreover, rodent studies have shown sex differences during adulthood in response to natural and drug rewards under normative conditions and in stress‐based rodent models. Yet, little is known about the development of reward‐related responses under normative conditions, including how these may differ in rats of both sexes during early development. Comparing reward‐related behavioral responses between developing male and female rats may be useful for understanding how these processes may be affected in rodent models relevant to psychiatric disorders. To this end, we tested behavioral responses to natural rewards in male and female rats using sucrose consumption, sweet palatable food intake and social play tests at two timepoints (peripuberty, adolescence). Our results suggest comparable responses to consummatory and social rewards in male and female rats during peripuberty and adolescence as no sex differences were found for sucrose preference, chocolate candy intake or a subset of play behaviors (dorsal contacts, pins). These findings suggest that sex differences in response to these natural rewards emerge and may be more robust during adulthood.
Decline in small mammal species richness in coastal‐central California, 1997–2013
Authors: Ghimirey Yadav P. , Tietje William D. , Polyakov Anne Y. , Hines James E. , Oli Madan K. 
Published: December 2023

AbstractThe richness and composition of a small mammal community inhabiting semiarid California oak woodland may be changing in response to climate change, but we know little about the causes or consequence of these changes. We applied a capture‐mark‐recapture model to 17 years (1997–2013) of live trapping data to estimate species‐specific abundances. The big‐eared woodrat was the most frequently captured species in the area, contributing 58% of total captures. All small mammal populations exhibited seasonal fluctuations, whereas those of the California mouse, brush mouse, and pinyon mouse declined during the study period. We also applied a multispecies dynamic occupancy model to our small mammal detection history data to estimate species richness, occupancy (), detection (p), local extinction (), and colonization () probabilities, and to discern factors affecting these parameters. We found that decreased from 0.369 ± 0.088 in 1997 to 0.248 ± 0.054 in 2013; was lower during the dry season (May–September) than the wet season (October–April) and was positively influenced by total seasonal rainfall (slope parameter,  = 0.859 ± 0.371; 95% CI = 0.132–1.587). Mean mammalian species richness decreased from 11.943 ± 0.461 in 1997 to 7.185 ± 0.425 in 2013. With highly variable climatic patterns expected in the future, especially increased frequency and intensity of droughts, it is important to monitor small mammal communities inhabiting threatened California oak woodlands.
Eastern redcedar roots create legacy effects that suppresses growth of prairie species
Authors: Bennion Leland D. , Ward David 
Published: December 2023

AbstractThe expansion of woody species from their historical ranges into grasslands is a global problem. Understanding the mechanisms that enable species to successfully establish and then re‐encroach following their removal is critical to effectively managing problem species. Legacy effects are a mechanism that could be critical to the reestablishment of woody encroachers following their removal. Legacy effects occur when a species alters the biotic and abiotic environment in a way that affects communities that establish subsequently. In this study, we assess whether the eastern redcedar (Juniperus virginiana), a North American woody encroacher, generates legacy effects that affect communities that establish following removal of this species from an experimental grass community. We conducted a series of experiments to evaluate the effects of J. virginiana, roots on the germination and growth of grasses and to determine if the effects of root‐addition treatments were derived from a microbial or allelopathic origin. Aqueous extracts of J. virginiana roots were found to inhibit the germination of grasses. We found escalating suppression of overall community biomass and the biomass of each individual species with increasing root treatments. Finally, we determined the origin of the observed suppressive effect is unlikely to be of microbial origin. Synthesis: Our results suggest that J. virginiana exudes an allelochemical into soils that inhibits the growth of certain grasses and thus has the potential to have legacy effects on future occupants. We suggest that the inhibition of the development of grasses in areas where J. virginiana has been removed is a mechanism that may favor the reestablishment of J. virginiana. Our results indicate the legacy effects of J. virginiana must be considered when conducting removal and restoration of J. virginiana infested lands.
Research on the capacity cost allocation and the electricity capacity price optimization method for a power system based on the BARY‐GA algorithm
Authors: Liu Hang , Liu Qing , He Rui , Li Feng , Luo Kaiyan 
Published: December 2023

AbstractUnder the new power system, a high proportion of new energy is widely connected to the power grid, and it is necessary to increase investment in centralized and distributed energy storage, flexible resource regulation, and transmission and distribution grids, resulting in an increase in power system costs. The current electricity capacity price does not reflect the economic value of the added system adequately, and flexible capacity is needed to ensure the safety of the power grid under the new power system. In the context of the transformation of the new power system and investment function, it is increasingly difficult to recover the costs according to the traditional electricity price. It is necessary to establish a coordinated development mechanism for the electricity capacity price and the electricity price that recovers the fixed costs according to the investment function to ensure a reasonable return on investment in flexible resources and to provide effective investment signals. Therefore, this work first studied and proposed a mechanism for the formation of capacity and electricity prices based on the proportion of allowed income and fixed costs at different voltage levels and calculates the level of electricity capacity (demand) prices and electricity consumption prices. Then, using the BARY curve, genetic algorithm, and clustering of user load rates, a collaborative mechanism between the electricity capacity price and the electricity price was designed. With the goal of optimizing the electricity capacity price and considering constraints such as the flexibility and reliability of the new power system, the ratio of the capacity cost allocated to the electricity capacity price by voltage level users to the capacity cost allocated to the electricity price was calculated, and the optimal combination of electricity capacity price and electricity price for different load‐rate intervals was determined. Finally, the effectiveness of the model was verified through numerical simulations. On the basis of the investment characteristics of the new power system, suggestions for a capacity pricing mechanism under the new power system were proposed from the perspectives of transfer capacity function, transfer electricity function, grid reliability, and environmental and social benefits.