bluuebunny/crossref_metadata_2025_split huggingface dataset:
TREM2‐IGF1 Mediated Glucometabolic Enhancement Underlies Microglial Neuroprotective Properties During Ischemic Stroke
Authors: Yang Sheng , Qin Chuan , Chen Man , Chu Yun‐Hui , Tang Yue , Zhou Luo‐Qi , Zhang Hang , Dong Ming‐Hao , Pang Xiao‐Wei , Chen Lian , Wu Long‐Jun , Tian Dai‐Shi , Wang Wei 
Published: December 2023

AbstractMicroglia, the major resident immune cells in the central nervous system, serve as the frontline soldiers against cerebral ischemic injuries, possibly along with metabolic alterations. However, signaling pathways involved in the regulation of microglial immunometabolism in ischemic stroke remain to be further elucidated. In this study, using single‐nuclei RNA sequencing, a microglial subcluster up‐regulated in ischemic brain tissues is identified, with high expression of Igf1 and Trem2, neuroprotective transcriptional signature and enhanced oxidative phosphorylation. Microglial depletion by PLX3397 exacerbates ischemic brain damage, which is reversed by repopulating the microglia with high Igf1 and Trem2 phenotype. Mechanistically, Igf1 serves as one of the major down‐stream molecules of Trem2, and Trem2‐Igf1 signaling axis regulates microglial functional and metabolic profiles, exerting neuroprotective effects on ischemic stroke. Overexpression of Igf1 and supplementation of cyclocreatine restore microglial glucometabolic levels and cellular functions even in the absence of Trem2. These findings suggest that Trem2‐Igf1 signaling axis reprograms microglial immunometabolic profiles and shifts microglia toward a neuroprotective phenotype, which has promising therapeutic potential in treating ischemic stroke.
Understanding the Stability of Copper Current Collector with Sulfide Electrolyte in All‐Solid‐State Batteries
Authors: Li Menglin , Wang Bo , Ma Jun , Wang Zaifa , Liang Yali , Wang Zhenyu , Zhang Liqiang , Tang Yongfu , Huang Qiao , Huang Jianyu 
Published: December 2023

AbstractSulfide‐based all‐solid‐state batteries (ASSBs) have attracted wide attention due to their notable advantages in energy density and enhanced safety. However, whether or not copper (Cu) current collectors can be adopted in sulfide‐based ASSBs remains unclear, as sulfide electrolyte (SE) may react with Cu, causing premature failure of the ASSBs. Herein it is reported that in the presence of traces amount of water, e.g. in a dry room with a dew point of −50 °C, the SE reacts with water to produce H2S, which corrodes Cu to produce Cu2S, causing serious performance degradation to the ASSBs. Conversely, in an anhydrous environment (such as within a glove box), SE is virtually inert to Cu, rendering Cu a valid current collector. This study establishes the conditions that Cu can be used as the current collectors for sulfide‐based ASSBs, which provides important guidance for the industrialization of ASSBs.
Surgery for adult head and neck rhabdomyosarcoma: A retrospective report from one institution
Authors: Wang Tian , Wang Jie , Tang Tianci , Li Qiang , Li Yi , Song Xinmao 
Published: December 2023

Key Points
Surgery in adults with head and neck rhabdomyosarcoma does not improve survival rates.
Surgery should be performed deliberately and focused on the timing of combined treatment modality.
Adult head and neck rhabdomyosarcoma benefits from salvage surgery following chemoradiotherapy.
Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders
Authors: Barbosa Bárbara M. G. , Sfyaki Aikaterini , Rafael Sergi , José‐Duran Ferran , Pous Joan , Sánchez‐Zarzalejo Carolina , Perez‐Lopez Carles , Vilanova Mar , Cigler Marko , Gay Marina , Vilaseca Marta , Winter Georg E. , Riera Antoni , Mayor‐Ruiz Cristina 
Published: December 2023

AbstractDegraders hold the promise to efficiently inactivate previously intractable disease‐relevant targets. Unlike traditional inhibitors, degraders act substoichiometrically and rely on the hijacked proteolysis machinery, which can also act as an entry point for resistance. To fully harness the potential of targeted protein degradation, it is crucial to comprehend resistance mechanisms and formulate effective strategies to overcome them. We conducted a chemical screening to identify synthetic lethal vulnerabilities of cancer cells that exhibit widespread resistance to degraders. Comparative profiling followed by tailored optimization delivered the small molecule RBS‐10, which shows preferential cytotoxicity against cells pan‐resistant to degraders. Multiomics deconvolution of the mechanism of action revealed that RBS‐10 acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1, which is highly overexpressed in our resistance models. Collectively, our work informs on NQO1 as an actionable vulnerability to overcome resistance to degraders and as a biomarker to selectively exploit bioactivatable prodrugs in cancer.
Pyridinium‐abgeleitete mesoionische N‐heterocyclische Olefine (py‐mNHOs)
Authors: Sun Qiu , Eitzinger Andreas , Esken Robin , Antoni Patrick W. , Mayer Robert J. , Ofial Armin R. , Hansmann Max M. 
Published: December 2023

AbstractMesoionische Polarisation ermöglicht den Zugang zu elektronenreichen Olefinen, die als Organokatalysatoren, Liganden oder Nucleophile Anwendung finden. Wir berichten hier über die Synthese und Charakterisierung einer Reihe von 3‐Methylpyridinium‐abgeleiteten mesoionischen Olefinen (py‐mNHOs). Wir verwendeten ein mit DFT‐Rechnungen unterstütztes Designkonzept, das zeigte, dass Arylgruppen an den 1‐, 2‐, 4‐ und 6‐Positionen des heterocyclischen Kerns die kinetische Stabilisierung der neuartigen mesoionischen Verbindungen ermöglicht. Die elektronischen Tolman‐Parameter zeigen, dass py‐mNHOs bemerkenswert starke σ‐Donor‐Liganden für Übergangsmetalle und Hauptgruppen‐Lewis‐Säuren sind. Außerdem gehören sie zu den stärksten Nucleophilen auf der Mayr‐Reaktivitätsskala. Bei Reaktionen von py‐mNHOs mit elektronenarmen π‐Systemen wurde experimentell ein sukzessiver Übergang von der Bildung zwitterionischer Addukte über schrittweise zu konzertierten 1,3‐dipolaren Cycloadditionen beobachtet und durch quantenchemische Rechnungen analysiert.
Precise Regulation of Multiple Resonance Distribution Regions of a B,N‐Embedded Polycyclic Aromatic Hydrocarbon to Customize Its BT2020 Green Emission
Authors: Wu Zheng‐Guang , Xin Yangyang , Lu Chaowu , Huang Weichun , Xu Haojie , Liang Xiao , Cao Xudong , Li Chong , Zhang Dongdong , Zhang Yuewei , Duan Lian 
Published: December 2023

AbstractRecently, boron (B)/nitrogen (N)‐embedded polycyclic aromatic hydrocarbons (PAHs), characterized by multiple resonances (MR), have attracted significant attention owing to their remarkable features of efficient narrowband emissions with small full width at half maxima (FWHMs). However, developing ultra‐narrowband pure‐green emitters that comply with the Broadcast Service Television 2020 (BT2020) standard remains challenging. Precise regulation of the MR distribution regions allows simultaneously achieving the emission maximum, FWHM value, and spectral shape that satisfy the BT2020 standard. The proof‐of‐concept molecule TPABO‐DICz exhibited ultrapure green emission with a dominant peak at 515 nm, an extremely small FWHM of 17 nm, and Commission Internationale de l′Eclairage (CIE) coordinates of (0.17, 0.76). The corresponding bottom‐emitting organic light‐emitting diode (OLED) exhibited a remarkably high CIEy value (0.74) and maximum external quantum efficiency (25.8 %). Notably, the top‐emitting OLED achieved nearly BT2020 green color (CIE: 0.14, 0.79) and exhibited a state‐of‐the‐art maximum current efficiency of 226.4 cd A−1, thus fully confirming the effectiveness of the above strategy.
Pyridinium‐Derived Mesoionic N‐Heterocyclic Olefins (py‐mNHOs)
Authors: Sun Qiu , Eitzinger Andreas , Esken Robin , Antoni Patrick W. , Mayer Robert J. , Ofial Armin R. , Hansmann Max M. 
Published: December 2023

AbstractMesoionic polarization allows access to electron‐rich olefins that have found application as organocatalysts, ligands, or nucleophiles. Herein, we report the synthesis and characterization of a series of 3‐methylpyridinium‐derived mesoionic olefins (py‐mNHOs). We used a DFT‐supported design concept, which showed that the introduction of aryl groups in the 1‐, 2‐, 4‐, and 6‐positions of the heterocyclic core allowed the kinetic stabilization of the novel mesoionic compounds. Tolman electronic parameters indicate that py‐mNHOs are remarkably strong σ‐donor ligands toward transition metals and main group Lewis acids. Additionally, they are among the strongest nucleophiles on the Mayr reactivity scale. In reactions of py‐mNHOs with electron‐poor π‐systems, a gradual transition from the formation of zwitterionic adducts via stepwise to concerted 1,3‐dipolar cycloadditions was observed experimentally and analyzed by quantum‐chemical calculations.
Ultrastrong Electron‐Phonon Coupling in Uranium‐Organic Frameworks Leading to Inverse Luminescence Temperature Dependence
Authors: Chen Dong‐Hui , Vankova Nina , Jha Gautam , Yu Xiaojuan , Wang Yuemin , Lin Ling , Kirschhöfer Frank , Greifenstein Raphael , Redel Engelbert , Heine Thomas , Wöll Christof 
Published: December 2023

AbstractElectron‐phonon interactions, crucial in condensed matter, are rarely seen in Metal–Organic Frameworks (MOFs). Detecting these interactions typically involves analyzing luminescence in lanthanide‐ or actinide‐based compounds. Prior studies on Ln‐ and Ac‐based MOFs at high temperatures revealed additional peaks, but these were too faint for thorough analysis. In our research, we fabricated a high‐quality, crystalline uranium‐based MOF (KIT‐U‐1) thin film using a layer‐by‐layer method. Under UV light, this film showed two distinct “hot bands,” indicating a strong electron‐phonon interaction. At 77 K, these bands were absent, but at 300 K, a new emission band appeared with half the intensity of the main luminescence. Surprisingly, a second hot band emerged above 320 K, deviating from previous findings in rare‐earth compounds. We conducted a detailed ab‐initio analysis employing time‐dependent density functional theory to understand this unusual behaviour and to identify the lattice vibration responsible for the strong electron‐phonon coupling. The KIT‐U‐1 film's hot‐band emission was then utilized to create a highly sensitive, single‐compound optical thermometer. This underscores the potential of high‐quality MOF thin films in exploiting the unique luminescence of lanthanides and actinides for advanced applications.
Synthesis and Properties of Azahomocorannulenyl Cations and Radicals
Authors: Hamamoto Yosuke , Ochiai Kotaro , Li Yongxin , Tapavicza Enrico , Ito Shingo 
Published: December 2023

AbstractCycloheptatrienyl (tropyl) molecules are representative non‐alternant hydrocarbons that offer interesting chemistry because of their unique structures and properties. However, there have been a limited number of polycyclic aromatic tropyl cations and radicals reported in the literature. Herein, we report the synthesis of a series of azahomocorannulene derivatives, where the key reactions are a 1,3‐dipolar cycloaddition of polycyclic aromatic azomethine ylides with dibenzotropone and a subsequent palladium‐catalyzed cyclization. X‐ray diffraction analysis revealed that the obtained azahomocorannulenyl cation and radical adopt planar structures and exhibit unique packing structures. Their electronic and optical properties were investigated experimentally and theoretically to reveal their aromatic character.
Association of neighborhood gentrification with prostate cancer and immune markers in African American and European American men
Authors: Pichardo Catherine M. , Ezeani Adaora , Pichardo Margaret S. , Agurs‐Collins Tanya , Powell‐Wiley Tiffany M. , Ryan Brid , Minas Tsion Zewdu , Bailey‐Whyte Maeve , Tang Wei , Dorsey Tiffany H. , Wooten William , Loffredo Christopher A. , Ambs Stefan 
Published: December 2023

AbstractBackgroundPrior studies showed that neighborhood deprivation increases the risk of lethal prostate cancer. However, the role of neighborhood gentrification in prostate cancer development and outcome remains poorly understood. We examined the relationships of gentrification with prostate cancer and serum proteome‐defined inflammation and immune function in a diverse cohort.MethodsThe case–control study included 769 cases [405 African American (AA), 364 European American (EA) men] and 1023 controls (479 AA and 544 EA), with 219 all‐cause and 59 prostate cancer‐specific deaths among cases. Geocodes were linked to a neighborhood gentrification index (NGI) derived from US Census data. Cox and logistic regression, and MANOVA, were used to determine associations between NGI, as continuous or quintiles (Q), and outcomes.ResultsAdjusting for individual socioeconomic status (SES), continuous NGI was positively associated with prostate cancer among all men (odds ratio [OR] 1.07, 95% confidence interval [CI] 1.01–1.14). AA and low‐income men experienced the highest odds of prostate cancer when residing in tracts with moderate gentrification, whereas EA men experienced reduced odds of regional/metastatic cancer with increased gentrification in SES‐adjusted analyses. Continuous NGI also associated with mortality among men presenting with localized disease and low‐income men in SES‐adjusted Cox regression analyses. NGI was not associated with serum proteome‐defined chemotaxis, inflammation, and tumor immunity suppression.ConclusionsFindings show that neighborhood gentrification associates with prostate cancer and mortality in this diverse population albeit associations were heterogenous within subgroups. The observations suggest that changing neighborhood socioeconomic environments may affect prostate cancer risk and outcome, likely through multifactorial mechanisms.
Urinary tract infection associated with bacteremia caused by vancomycin‐resistant enterococcus following continent urinary diversion
Authors: Morishita Kai , Kashiwabara Soichiro , Matsumoto Yuki , Mizushima Atsuhiro , Hara Kaori , Agatsuma Toshihiko , Mimura Yuji , Matsumura Hideyoshi , Mizusawa Hiroya 
Published: December 2023

Key Clinical MessageEven in a country where vancomycin–resistant enterococcus is rare, multidrug‐resistant organism precautions are necessary when admitting patients with a history of medical exposure in other countries. On admission, screening is necessary and if infection is confirmed, a multidisciplinary approach involving different specialists is required.AbstractThe patient was a 49‐year‐old Japanese female living in the United States. Total pelvic exenteration for cervical carcinoma, Miami pouch formation, and ileostomy had been performed in the United States. She returned to Japan to undergo postoperative adjuvant chemotherapy. Fever and abdominal pain occurred 42 days after surgery. She consulted the fever outpatient clinic, and a diagnosis of urinary retention‐associated acute renal failure and pyelonephritis was made. We detected vancomycin‐resistant enterococcus on urine/blood culture 5 days after admission. Infection control measures were implemented, and the ward was closed for 3 days. We administered linezolid, which was effective for pyelonephritis and bacteremia.
Endoscopic retrieval of 195 incidentally found ingested magnets in a pediatric patient: The limitations of radiography
Authors: Al Tamr Wissam Jamal , Omran Kareem , Aldisi Mohammad , Matta Hilal , Nada Mohamed 
Published: December 2023

Key Clinical MessageIngestion of magnetic foreign bodies in children can present elusively on radiographs, requiring detailed history for accurate intervention guidance. Clustering and the weight of multiple magnets may indicate falsely distal positions in the GI tract.
Mitochondrion: Main organelle in orchestrating cancer escape from chemotherapy
Authors: Mostafavi Samaneh , Eskandari Nahid 
Published: December 2023

AbstractBackgroundChemoresistance is a challenging barrier to cancer therapy, and in this context, the role of mitochondria is significant. We put emphasis on key biological characteristics of mitochondria, contributing to tumor escape from various therapies, to find the “Achilles' Heel” of cancer cells for future drug design.Recent findingsThe mitochondrion is a dynamic organelle, and its existence is important for tumor growth. Its metabolites also cooperate with cell signaling in tumor proliferation and drug resistance.ConclusionBiological characteristics of this organelle, such as redox balance, DNA depletion, and metabolic reprogramming, provide flexibility to cancer cells to cope with therapy‐induced stress.
Calibration training for improving probabilistic judgments using an interactive app
Authors: Gruetzemacher Ross , Lee Kang Bok , Paradice David 
Published: December 2023

AbstractWe describe an exploratory study examining the effectiveness of an interactive app and a novel training process for improving calibration and reducing overconfidence in probabilistic judgments. We evaluated the training used in the app by conducting an American college football forecasting tournament involving 153 business school students making 52 forecasts over 11 weeks. A coarsened exact matching analysis found statistical evidence that, in under 30 min, the more challenging training was able to modestly reduce overconfidence, improve calibration and improve the accuracy of probabilistic judgments (measured by the Brier score). The experimental results also suggest that the generic training can generalize across domains and that effective calibration training is possible without expert facilitators or pedagogical training materials. Although no previous studies have reported similar results, due to the modest effect, we conclude that these results should only be interpreted as a proof of concept and that further evaluation and validation of mechanisms of the app's effect is necessary.
Regulatory effects of mangiferin on LPS‐induced inflammatory responses and intestinal flora imbalance during sepsis
Authors: Chang Bo‐tao , Wang Yang , Tu Wen‐lian , Zhang Zhi‐qing , Pu Yan‐fang , Xie Li , Yuan Fang , Gao Ying , Xu Ning , Yao Qi 
Published: December 2023

AbstractStudies suggest that mangiferin (MAF) has good therapeutic effects on chronic bronchitis and hepatitis. Also, it is one of the antiviral ingredients in Anemarrhena asphodeloides Bunge. However, its effect on the LPS‐induced inflammation and intestinal flora during sepsis remains unclear yet. In the present study, LPS‐stimulated inflammation RAW264.7 cells and LPS‐induced sepsis mice were used to evaluate the efficacy of MAF in vitro and in vivo. 16S rDNA sequencing was performed to analyze the characteristics of intestinal flora of the sepsis mice. It has been demonstrated that MAF (12.5 and 25 μg/mL) significantly inhibited protein expressions of TLR4, MyD88, NF‐κB, and TNF‐α in the LPS‐treated cells and reduced the supernatant TNF‐α and IL‐6 levels. In vivo, MAF (20 mg/kg) markedly protected the sepsis mice and reduced the serum TNF‐α and IL‐6 levels. Also, MAF significantly downregulated the protein expressions of TLR4, NF‐κB, and MyD88 in the livers. Importantly, MAF significantly attenuated the pathological injuries of the livers and small intestines. Further, MAF significantly increased proportion of Bacteroidota and decreased the proportions of Firmicutes, Desulfobacterota, Actinobacteriota, and Proteobacteria at phylum level, and it markedly reduced the proportions of Escherichia‐Shigella, Pseudoalteromonas, Staphylococcus at genus level. Moreover, MAF affects some metabolism‐related pathways such as citrate cycle (TCA cycle), lipoic acid metabolism, oxidative phosphorylation, bacterial chemotaxis, fatty acid biosynthesis, and peptidoglycan biosynthesis of the intestinal flora. Thus, it can be concluded that MAF as a treatment reduces the inflammatory responses in vitro and in vivo by inhibiting the TLR4/ MyD88/NF‐κB pathway, and corrects intestinal flora imbalance during sepsis to some degree.
Effects of collagen‐based coating with chitosan and ε‐polylysine on sensory, texture, and biochemical changes of refrigerated Nemipterus virgatus fillets
Authors: Huang Yongping , Nie Ying , Zhou Fei , Li Biansheng , Luo Qiulan , Zhang Bin , Zeng Qinpei , Huang Yisheng 
Published: December 2023

AbstractIn order to evaluate the effects of chitosan, ε‐polylysine, and collagen on the preservation properties of refrigerated Nemipterus virgatus, samples were tested with different treatments for 10 days, namely chitosan, ε‐polylysine and collagen (CH + ε‐PL + CA), chitosan and ε‐polylysine (CH + ε‐PL), chitosan and collagen (CH + CA), ε‐polylysine and collagen (ε‐PL + CA), and the uncoated sample (CK). The results demonstrated that the bio‐coating exhibited better preservation effects. The CH + ε‐PL + CA, CH + ε‐PL, CH + CA, ε‐PL + CA treatments could significantly inhibit bacterial growth and retard the increase of total volatile base nitrogen (TVB‐N), 2‐thiobarbituric acid (TBA), K‐value, and total viable counts (TVC) in N. virgatus fillets. The pH of all samples decreased and reached its lowest value on day 6, then increased significantly at the end of the experiment (p < .05). Water‐holding capacity (WHC) of all the groups decreased continuously throughout storage, and CK reached 66.03% on day 6, which is significantly lower than CH + ε‐PL + CA, CH + ε‐PL, CH + CA, and ε‐PL + CA (p < .05). On the contrary, the sensory scores of CH + ε‐PL + CA, CH + ε‐PL, CH + CA, and ε‐PL + CA were significantly higher than the control, and the score of CH + ε‐PL + CA (p < .05) was the best among all the groups. In terms of texture, CH + PL + CA also showed less cell shrinkage and tighter muscle fiber arrangement compared to other treatments. To sum up, the CH + PL + CA bio‐coating proved to be a promising method for maintaining the storage quality of N. virgatus under refrigerated storage conditions.
Therapeutic antibody targeting natriuretic peptide receptor 1 inhibits gastric cancer growth viaBCL‐2‐mediated intrinsic apoptosis
Authors: Sasahara Masahiro , Kanda Mitsuro , Tanaka Chie , Shimizu Dai , Umeda Shinichi , Takami Hideki , Inokawa Yoshikuni , Hattori Norifumi , Hayashi Masamichi , Nakayama Goro , Kodera Yasuhiro 
Published: December 2023

AbstractDespite recent advances in the development of therapeutic antibodies, the prognosis of unresectable or metastatic gastric cancer (GC) remains poor. Here, we searched for genes involved in the malignant phenotype of GC and investigated the potential of one candidate gene to serve as a novel therapeutic target. Analysis of transcriptome datasets of GC identified natriuretic peptide receptor 1 (NPR1), a plasma membrane protein, as a potential target. We employed a panel of human GC cell lines and gene‐specific small interfering RNA‐mediated NPR1 silencing to investigate the roles of NPR1 in malignancy‐associated functions and intracellular signaling pathways. We generated an anti‐NPR1 polyclonal antibody and examined its efficacy in a mouse xenograft model of GC peritoneal dissemination. Associations between NPR1 expression in GC tissue and clinicopathological factors were also evaluated. NPR1 mRNA was significantly upregulated in several GC cell lines compared with normal epithelial cells. NPR1 silencing attenuated GC cell proliferation, invasion, and migration, and additionally induced the intrinsic apoptosis pathway associated with mitochondrial dysfunction and caspase activation via downregulation of BCL‐2. Administration of anti‐NPR1 antibody significantly reduced the number and volume of GC peritoneal tumors in xenografted mice. High expression of NPR1 mRNA in clinical GC specimens was associated with a significantly higher rate of postoperative recurrence and poorer prognosis. NPR1 regulates the intrinsic apoptosis pathway and plays an important role in promoting the GC malignant phenotype. Inhibition of NPR1 with antibodies may have potential as a novel therapeutic modality for unresectable or metastatic GC.