bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of TGF-β signaling pathway gene polymorphisms with unexplained recurrent spontaneous abortion
Authors: Xue Huiqin , Jiang Jinsong , Gao Jingbo , Guo Min , Tang Qiaoyin , Li Xinyan , Lu Hongyong , Sun Xiayu , Wu Jianrui , Zhang Yuping 
Published: February 2024

Background:
The association of key genes in the transforming growth factor-β (TGF-β) signaling pathway and their gene polymorphisms with unexplained recurrent spontaneous abortion (URSA) is unclear.

Objective:
To investigate the association of gene polymorphisms related to the TGF-β signaling pathway in URSA women.

Methods:
The study population consisted of 80 women with URSA and 90 normal control women, of which 10 women with URSA and 10 normal control women underwent high-throughput sequencing to select loci, and the remaining 70 women with URSA and 80 normal control women underwent flight mass spectrometry experiments to verify gene loci polymorphism. A total of 7 polymorphic loci in interleukin-6 (IL-6), TGF-β1, TNF-α, SMAD1, and TNFRSF4 genes were screened by high-throughput sequencing combined with a review of databases. An SNP flight mass spectrometer (Mass ARRAY detection system) was applied to detect the polymorphisms and their frequencies in 70 women with URSA and 80 normal control women at the 7 gene loci.

Results:
Among the 7 loci of IL-6, TGF-β1, TNF-α, SMAD1, and TNFRSF4 genes, 2 loci were found to have significantly different allele and genotype frequency distributions between the 70 URSA and 80 normal controls, one was the IL-6 gene -174G/C locus (rs1800795), the risk of disease was 2.636 and 3.231 times higher in individuals carrying the C allele and CC genotype than in those carrying the G allele and GG genotype, respectively; the other was the TGF-β1 gene -509T/C locus (rs1800469), and the risk of disease was 1.959 and 3.609 times higher in individuals carrying the T allele and TT genotype than in those carrying the C allele and CC genotype, respectively. The remaining 5 genetic loci have no statistically significant.

Conclusion:
IL-6 gene -174G/C locus (rs1800795) genotype CC and allele C may be the causative factor of URSA, TGF-β1 gene -509T/C locus (rs1800469) genotype TT and allele T may be the causative factor of URSA, and polymorphisms of the 2 loci may be associated with URSA.
Effects of intraoperative or postoperative administration of intravenous iron supplements on hemoglobin recovery in patients with total knee arthroplasty: A systematic review and meta-analysis
Authors: Kwak Sang Gyu , Kwon Jae Bum , Bae Jin Woo , Bae Dong Jin , Kim Dong Kun , Choi Won-Kee 
Published: February 2024

Background:
The objectives of the researchers are as follows: First, to investigate whether intraoperative or postoperative administration of Intravenous (IV) iron supplements in patients undergoing primary total knee arthroplasty (TKA) can contribute to the hemoglobin recovery during the postoperative period (between 4 and 8 weeks after surgery). Second, to examine whether the administration of IV iron supplements during or immediately after TKA in patients undergoing primary TKA can reduce the need for allogenic blood transfusion during hospitalization.

Methods:
Articles published between January 1, 1990, and June 30, 2023 were searched in PubMed, Cochrane, and Embase. The population, intervention, comparison, and outcome of this study are as follows; Population: Patients undergoing primary total knee arthroplasty; Intervention: Administration of IV iron supplements during or immediately after surgery; Comparison: Non-administration of IV iron supplements; Outcome: Degree of hemoglobin recovery (between 4 and 8 weeks after surgery) and the need for blood transfusion during hospitalization.

Results:
There was a statistically significant difference in the amount of change in hemoglobin between iron supplementation group and non-iron supplementation group. The effect size were −0.44 (95% confidence interval: −0.69 to −0.19, P value < .001) in all patients. This means that the amount of change in hemoglobin were significantly reduced in the iron supplementation group than in the non-iron supplementation group. There was a statistically significant difference for post-operative transfusion rate between 2 groups. The effect size were 0.28 (95% confidence interval: 0.10–0.81, P value = .02) in all patients. This means that the post-operative transfusion rate was significantly less in the iron supplementation group than in the non-iron supplementation group

Conclusion:
The administration of IV iron supplements during or after TKA surgery increases hemoglobin recovery between 4 and 8 weeks after surgery and reduces the need for allogeneic blood transfusion during hospitalization.
NAA10 gene related Ogden syndrome with obstructive hypertrophic cardiomyopathy: A rare case report
Authors: Li Feihong , Wang Wenyang , Li Yazhou , Liu Xiwang , Zhu Zhirui , Tang Jian , Hu Yaoqin 
Published: February 2024

Rationale:
Ogden syndrome is an exceptionally rare X-linked disease caused by mutations in the NAA10 gene. Reported cases of this syndrome are approximately 20 children and are associated with facial dysmorphism, growth delay, developmental disorders, congenital heart disease, and arrhythmia.

Patient concerns:
We present the clinical profile of a 3-year-old girl with Ogden syndrome carrying a de novo NAA10 variant [NM_003491:c.247C>T, p.(Arg83Cys)]. During infancy, she exhibited features such as left ventricular hypertrophy, protruding eyeballs, and facial deformities.

Diagnosis:
Clinical diagnosis included Ogden syndrome, congenital heart disease (obstructive hypertrophic cardiomyopathy, left ventricular outflow tract obstruction, mitral valve disease, tricuspid valve regurgitation), tonsillar and adenoidal hypertrophy, and speech and language delay.

Interventions:
The girl was considered to have hypertrophic cardiomyopathy (HCM) and received oral metoprolol as a treatment for HCM at our hospital. The drug treatment effect was not ideal, and her hypertrophy myocardial symptoms were aggravated and she had to be hospitalized for surgery.

Outcomes:
The girl underwent a modified Morrow procedure under cardiopulmonary bypass and experienced a favorable postoperative recovery. No pulmonary infections or significant complications were observed during this period. The patient’s family expressed satisfaction with the treatment process.

Lessons:
The case emphasizes the HCM of Odgen syndrome, and early surgery should be performed if drug treatment is ineffective.
Tuberous sclerosis complex: A clinical diagnosis in Ethiopian patients
Authors: Sisay Belete , Tadesse Abilo , Gelaw Abebe , Getahun Desalew , Mulat Biruk , Kebede Weynishet , Gebrewold Yonathan 
Published: February 2024

Rationale:
Tuberous sclerosis complex (TSC) is a rare autosomal dominant inherited disorder characterized by the development of nonmalignant tissue growths (hamartomas) in various organ systems, often located in the brain, skin, heart, lung and kidneys. The delayed diagnosis could be attributed to low expectation or exposure of physicians to this rare disease. High index of clinical suspicion is required for early diagnosis of rare diseases to prevent adverse outcomes.

Patient concerns:
The first patient, a 27-year-old man, presented with intermittent left flank pain and hematuria of 5 months duration. On examination of the skin and oral cavity, he had fibrous cephalic plaque, facial angiofibromas, ungual fibromas, confetti skin lesions, and intraoral fibromas. A CT scan of the chest, abdomen, and brain displayed cystic lung parenchymal changes and multifocal micronodular pneumocyte hyperplasia, angiomyolipomas in both kidneys, and multiple calcified subependymal nodules (SEN), respectively. The second patient, a 28-year-old woman, presented with a seizure disorder in the last 1 year, and papular and nodular lesions over her face since childhood. On examination of the skin and oral cavity, she had hypomelanotic macules, facial angiofibromas, shagreen patches, ungual fibromas, intraoral fibromas, and dental enamel pits.

Diagnoses:
Definitive diagnosis of TSC was made in both patients using the “2012 tuberous sclerosis complex diagnostic criteria consensus statement.”

Interventions:
The first patient was seen by various medical discipline teams, and suggested close follow-up in the “chronic illness clinic” of the hospital. The second patient was scheduled in dermatology clinic for electrocautery for disfiguring facial nodules.

Outcome:
Both patients were scheduled for close follow-up in the hospital.

Lessons:
The patients described had TSC using “clinical diagnostic criteria.” Under the clinical diagnostic criteria of TSC, 4 of 11 major criteria and 3 of 7 minor criteria are skin features. Hence, awareness on skin features as clinical markers to suspect TSC should be emphasized in resource-limited countries.
Intraosseous hemangioma with aneurysmal bone cyst-like changes of the hyoid bone: Case report and literature review
Authors: Oh Jeonghyun , Han Song Iy , Lim Sung-Chul 
Published: February 2024

Rationale:
Intraosseous hemangioma is a rare benign vascular tumor of the bone that can affect any body part; however, the most common site is the vertebra, followed by calvarial bones.

Patient concerns:
We present a case of intraosseous hemangioma in a 23-year-old male who presented a feeling of fullness in the throat for 3 months. The hyoid bone level had a hard mass of about 5 cm. Fine needle aspiration showed 5 mL dark bloody aspirates. Magnetic resonance image showed a 5.3 cm mixed signal intensity lesion in the hyoid body.

Diagnosis:
Histopathologic examination showed intraosseous hemangioma with aneurysmal bone cyst (ABC)-like changes in the hyoid bone.

Interventions:
The mass was completely removed without significant problems.

Outcomes:
Complete mass excision and symptomatic improvements were achieved, and no subsequent relapses were observed.

Lessons:
The authors experienced a case of intraosseous hemangioma with ABC-like changes. There has been no case report of intraosseous hemangioma in the hyoid bone. This case showed a spectral pattern of the ABC-like changes developing from the underlying bone tumor as a secondary change. ABC-like changes in bone tumors can mislead the diagnosis. Careful examination of the tumor is essential for the correct diagnosis of ABC or ABC-like changes.
New guidelines and therapeutic updates for the management of lupus nephritis
Authors: Desai Sheetal B. , Ahdoot Rebecca , Malik Fatima , Obert Michele , Hanna Ramy 
Published: February 2024

Purpose of review
Systemic lupus erythematosus (SLE) can be a devastating condition, striking young patients often in their prime reproductive years. Lupus nephritis is a common and serious complication occurring in roughly 50% of SLE cases, indicating a high likelihood of disease progression, morbidity, and mortality. As the early trials of steroid therapy, and later cyclophosphamide (CYC), therapeutic changes had been stagnant. Then came the introduction of mycophenolate mofetil (MMF) in the 2000s. After the Aspreva Lupus Management Study, there had been a dearth of trials showing positive therapy results. Since 2020, new studies have emerged for lupus nephritis involving the use of anti-BLYS agents, novel calcineurin inhibitors, CD20 blockade, and antiinterferon agents. Nephrology and rheumatology society guidelines in the United States and across the world are still catching up.

Recent findings
Although therapeutic guidelines are being developed, updates that have come through have focused on improved diagnostic and monitoring guidelines. One theme is the recommendation of increasingly tight proteinuria control and firmer guidelines for the rapid induction of remission. The reality of multitarget therapy and the expectation of rapid induction for a more complete remission are being widely recognized.

Summary
The need for more complete and more rapid induction and control of lupus nephritis is undisputed according to the evidence and guidelines, and the medications to achieve this are growing at a rate not seen over the prior two decades. What remains is a stepwise approach to recognize how to best optimize therapy. Based on available evidence, an algorithm for induction and maintenance treatment of lupus nephritis used by the University of California Irvine Lupus Nephritis clinic, is recommended.
Polyethylene Glycol–Mediated Axonal Fusion Promotes Early Sensory Recovery after Digital Nerve Injury: A Randomized Clinical Trial
Authors: Nemani Sriya , Chaker Sara , Ismail Helen , Yao Julia , Chang Monal , Kang Hakmook , Desai Mihir , Weikert Douglas , Bhandari Panambur L. , Drolet Brian , Sandvall Brinkley , Hill John B. , Thayer Wesley 
Published: February 2024

Background:
Peripheral nerve repair is limited by Wallerian degeneration coupled with the slow and inconsistent rates of nerve regrowth. In more proximal injuries, delayed nerve regeneration can cause debilitating muscle atrophy. Topical application of polyethylene glycol (PEG) during neurorrhaphy facilitates the fusion of severed axonal membranes, immediately restoring action potentials across the coaptation site. In preclinical animal models, PEG fusion resulted in remarkable early functional recovery.

Methods:
This is the first randomized clinical trial comparing functional outcomes between PEG fusion and standard neurorrhaphy. Participants with digital nerve transections were followed up at 2 weeks, 1 month, and 3 months postoperatively. The primary outcome was assessed using the Medical Research Council Classification (MRCC) rating for sensory recovery at each time point. Semmes-Weinstein monofilaments and static 2-point discrimination determined MRCC ratings. Postoperative quality of life was measured using the Michigan Hand Outcomes Questionnaire.

Results:
Forty-eight transected digital nerves (25 control and 23 PEG) across 22 patients were analyzed. PEG-fused nerves demonstrated significantly higher MRCC scores at 2 weeks (OR, 16.95; 95% CI, 1.79 to 160.38; P = 0.008) and 1 month (OR, 13.40; 95% CI, 1.64 to 109.77; P = 0.009). Participants in the PEG cohort also had significantly higher average Michigan Hand Outcomes Questionnaire scores at 2 weeks (Hodge g, 1.28; 95% CI, 0.23 to 2.30; P = 0.0163) and 1 month (Hodge g, 1.02; 95% CI, 0.04 to 1.99; P = 0.049). No participants had adverse events related to the study drug.

Conclusion:
PEG fusion promotes early sensory recovery and improved patient well-being following peripheral nerve repair of digital nerves.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, II.
American Crow responses to habitat desaturation by West Nile virus
Authors: Caffrey Carolee 
Published: February 2024

AbstractIn late Summer 2002, West Nile virus spread to a population of individually-marked, cooperatively-breeding American Crows (Corvus brachyrhynchos brachyrhynchos) in Stillwater, OK. Within six weeks, approximately 42% of adults were dead, leaving widows, widowers, and vacant territories. I looked to see if surviving unpaired adult crows left groups to occupy vacant territories, as predicted by theory (Habitat Saturation/Ecological Constraints Hypothesis; Emlen 1982, 1984). Survivors did not behave as predicted, had previous decisions to delay breeding and live in others’ groups been made in response to a saturated habitat. Their aberrant behavior and physical attitudes suggested their losses and grief affected them in ways not included in simplistic models of avian behavior.
Adapting to loss: A normative account of grief
Authors: Dulberg Zack , Dubey Rachit , Cohen Jonathan D. 
Published: February 2024

AbstractGrief is a reaction to loss that is observed across human cultures and even in other species. While the particular expressions of grief vary significantly, universal aspects include experiences of emotional pain and frequent remembering of what was lost. Despite its prevalence, and its obvious nature, considering grief from a normative perspective is puzzling:Whydo we grieve? Why is itpainful? And why is it sometimes prolonged enough to be clinically impairing? Using the framework of reinforcement learning with memory replay, we offer answers to these questions and suggest, counter-intuitively, that grief may have normative value with respect to reward maximization.
The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms
Authors: Wang Qian , Liu Jinxin , Luo Yuhang , Kliemke Vicky , Matta Giuliana Leonarda , Wang Jingjing , Liu Qian 
Published: February 2024

AbstractParamyxovirus membrane fusion requires an attachment protein for receptor binding and a fusion protein for membrane fusion triggering. Nipah virus (NiV) attachment protein (G) binds to ephrinB2 or -B3 receptors, and fusion protein (F) mediates membrane fusion. NiV-F is a class I fusion protein and is activated by endosomal cleavage. The crystal structure of a soluble GCN4-decorated NiV-F shows a hexamer-of-trimer assembly. Here, we used single-molecule localization microscopy to quantify the NiV-F distribution and organization on cell and virus-like-particle membranes at a nanometer precision. We found that NiV-F on biological membranes forms distinctive clusters that are independent of endosomal cleavage or expression levels. The sequestration of NiV-F into dense clusters favors membrane fusion triggering. The nano-distribution and organization of NiV-F are susceptible to mutations at the hexamer-of-trimer interface, and the putative oligomerization motif on the transmembrane domain. We also show that NiV-F nanoclusters are maintained by NiV-F-AP-2 interactions and the clathrin coat assembly. We propose that the organization of NiV-F into nanoclusters facilitates membrane fusion triggering by a mixed population of NiV-F molecules with varied degrees of cleavage and opportunities for interacting with the NiV-G/receptor complex. These observations provide insights into the in-situ organization and activation mechanisms of the NiV fusion machinery.
Organized complexity of CSA communication strategy
Authors: Choi Minhee , Song Baobao 
Published: February 2024

PurposeBased on Lasswell’s communication model, this study investigates how four categories of factors (i.e. the source, content, medium and receiver) conjointly affect the relational, financial and social outcomes (i.e. what effect) of CSA communication.Design/methodology/approachWith a survey (N = 366), this study found configurations of core CSA communication factors leading to three different CSA communication outcomes.FindingsWhile this study found multiways to yield three different CSA outcomes, combinational logic indicated the combined effects from source, content, medium and receiver. With content and medium, individuals’ connectedness (receiver) to a CSA issue is a core factor leading to a high level of purchase intention and issue advocacy. This study also found that message strategies (i.e. informativeness, factual tone, no promotional tone) are core factors leading to a high level of trust and issue advocacy.Practical implicationsWith the theoretical guidance, this research contributes to strategic communication practice for various entities involved in advocacy communication by enabling an improved understanding of advocacy communication factors and triggering different communication outcomes.Originality/valueAs CSA communication involves multiple strategies, conventional research agenda focusing on correlational and path analysis approaches provide limited understanding of communication practice. To fill this void, this study adopts a configurational approach to understand current CSA communication practices holistically.
Alleviating urban poverty in India: the role of capabilities and entrepreneurship development
Authors: Singh Jaskirat , Singh Manjit 
Published: February 2024

PurposeThis study investigates how enhancing slum dwellers' capabilities influences their entrepreneurship development and contributes to urban poverty reduction, providing insights for social policy design.Design/methodology/approachA quantitative research design is adopted applying structural equation modeling to survey data from 585 beneficiaries of social welfare schemes across Indian slums.FindingsEducational, economic and sociocultural capabilities positively impact quantitative and qualitative dimensions of slum entrepreneurship development, which reduces urban poverty, supporting the hypothesized relationships grounded in the Capability Approach.Research limitations/implicationsThe cross-sectional data limits causal inference. Wider sampling can improve generalizability. Capability antecedents of entrepreneurship merit further investigation across contexts.Practical implicationsIntegrated policy initiatives focused on education, skill building, access to finance and markets can leverage entrepreneurship for sustainable urban poverty alleviation.Social implicationsEnhancing slum dweller capabilities fosters entrepreneurship and empowerment, enabling people to shape their own destinies and reduce deprivations.Originality/valueThe research provides timely empirical validation of the Capability Approach and evidence-based insights to inform social policy aiming to alleviate urban poverty via entrepreneurship in developing countries.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-07-2023-0514.
Contribution of cultural heritage resources to the 2030 agenda SDGS
Authors: Rosique Rodríguez María Victoria , de-Prado Ruiz-Santaella Carmen , Jordano Barbudo María Ángeles 
Published: February 2024

PurposeThe 2030 Agenda and the sustainable development goals (SDGs) constitute a new global roadmap for all institutions and sectors of society. Therefore, thanks to the initiative of Club of Córdoba for the Unesco (CUCO), a nonprofit association, in collaboration with the University of Cordoba, the need to create a tool for heritage management has been identified to guide personnel responsible for cultural heritage resources in the implementation of SDGs. The goal of this universal guide is to raise awareness of the importance of cultural heritage resources being aligned with the 2030 Agenda and provide the keys to apply the SDGs in the day-to-day activities of the different institutions. This publication is part of the proyect of the Junta de Andalucía “The Guide to Action on a Heritage Resource on the SDGs” (GARPODS).Design/methodology/approachSDG Compass is a powerful tool for the application of the SDGs in the business field and therefore has been considered appropriate to create a guide for cultural heritage resources based on it. To this end, we have held meetings with experts in the heritage field (directors and managers of different heritage resources in the province of Córdoba) both individually and collectively. Surveys have also been carried out on different interest groups (managers, employees, suppliers, visitors) which in turn have made it possible to provide an interdisciplinary nature to the sample and the results.FindingsWith the completion of this work, it has been proven that cultural heritage resource managers lack the necessary knowledge and resources to implement the SDGs in their management. Therefore, the proposed guide will be a practical tool that will allow all heritage resources to incorporate the SDGs into their management.Originality/valueThe tool proposed in this work, although it based on the SDG Compass methodology, aims to go beyond the business sphere and adapt to heritage resources so that they can apply the SDGs in their management. This work is ongoing and the full guide will be presented in February 2024.