bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of genes associated with abiotic stress tolerance in sweetpotato using weighted gene co‐expression network analysis
Authors: Kitavi Mercy , Gemenet Dorcus C. , Wood Joshua C. , Hamilton John P. , Wu Shan , Fei Zhangjun , Khan Awais , Buell C. Robin 
Published: October 2023

AbstractSweetpotato, Ipomoea batatas (L.), a key food security crop, is negatively impacted by heat, drought, and salinity stress. The orange‐fleshed sweetpotato cultivar “Beauregard” was exposed to heat, salt, and drought treatments for 24 and 48 h to identify genes responding to each stress condition in leaves. Analysis revealed both common (35 up regulated, 259 down regulated genes in the three stress conditions) and unique sets of up regulated (1337 genes by drought, 516 genes by heat, and 97 genes by salt stress) and down regulated (2445 genes by drought, 678 genes by heat, and 204 genes by salt stress) differentially expressed genes (DEGs) suggesting common, yet stress‐specific transcriptional responses to these three abiotic stressors. Gene Ontology analysis of down regulated DEGs common to both heat and salt stress revealed enrichment of terms associated with “cell population proliferation” suggestive of an impact on the cell cycle by the two stress conditions. To identify shared and unique gene co‐expression networks under multiple abiotic stress conditions, weighted gene co‐expression network analysis was performed using gene expression profiles from heat, salt, and drought stress treated ‘Beauregard’ leaves yielding 18 co‐expression modules. One module was enriched for “response to water deprivation,” “response to abscisic acid,” and “nitrate transport” indicating synergetic crosstalk between nitrogen, water, and phytohormones with genes encoding osmotin, cell expansion, and cell wall modification proteins present as key hub genes in this drought‐associated module. This research lays the groundwork for exploring to a further degree, mechanisms for abiotic stress tolerance in sweetpotato.
Differences in muscle activity during squat exercises according to the knee angle and standing angle of a sliding tilt table: A comparative study
Authors: Park Tae Sung , Shin Myung‐Jun , Kang Jong Ho 
Published: October 2023

AbstractBackground and PurposeWeight‐bearing exercises can help improve physical function; however, they may be difficult to perform in patients with neurological issues or lower limb fractures. The purpose of this study was to evaluate the activity of the leg muscles during squatting when using a new exercise aid designed to help patients with difficulty in performing squats, termed the sliding tilt table, at different knee angles and to estimate the squat level for each angle.MethodsThis study was a cross‐sectional, observational study performed in the general community. Participants comprised 30 healthy adult men. Squats were performed by setting the knee joints at 30, 60, and 90° and the tilt table angles to 15, 30, and 45°. The muscle activity of the vastus medialis, tibialis anterior, and gastrocnemius was measured using surface electromyography.ResultsAs the tilt table and knee joint angle increased, the %maximal voluntary isometric contraction increased. Similar patterns were found in both legs.ConclusionsWeight‐bearing exercises, such as squats, are important exercise elements in patients who require lower limb rehabilitation. Therefore, it is necessary to provide efficient lower limb rehabilitation exercises by adjusting the squat level according to the patient's ability, which can be achieved using a sliding tilt table.
Duration of and time to response in oncology clinical trials from the perspective of the estimand framework
Authors: Weber Hans‐Jochen , Corson Stephen , Li Jiang , Mercier François , Roychoudhury Satrajit , Sailer Martin Oliver , Sun Steven , Todd Alexander , Yung Godwin ,   the Industry Working Group on Estimands in Oncology
Published: October 2023

AbstractDuration of response (DOR) and time to response (TTR) are typically evaluated as secondary endpoints in early‐stage clinical studies in oncology when efficacy is assessed by the best overall response and presented as the overall response rate. Despite common use of DOR and TTR in particular in single‐arm studies, the definition of these endpoints and the questions they are intended to answer remain unclear. Motivated by the estimand framework, we present relevant scientific questions of interest for DOR and TTR and propose corresponding estimand definitions. We elaborate on how to deal with relevant intercurrent events which should follow the same considerations as implemented for the primary response estimand. A case study in mantle cell lymphoma illustrates the implementation of relevant estimands of DOR and TTR. We close the paper with practical recommendations to implement DOR and TTR in clinical study protocols.
The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities
Authors: Mia Md. Abdur Rashid , Dey Dipta , Sakib Musfiqur Rahman , Biswas Md. Yeaman , Prottay Abdullah Al Shamsh , Paul Niloy , Rimti Fahmida Hoque , Abdullah Yusuf , Biswas Partha , Iftehimul Md. , Paul Priyanka , Sarkar Chandan , El‐Nashar Heba A. S. , El‐Shazly Mohamed , Islam Muhammad Torequl 
Published: October 2023

AbstractGlobally, prostate cancer (PCa) is regarded as a challenging health issue, and the number of PCa patients continues to rise despite the availability of effective treatments in recent decades. The current therapy with chemotherapeutic drugs has been largely ineffective due to multidrug resistance and the conventional treatment has restricted drug accessibility to malignant tissues, necessitating a higher dosage resulting in increased cytotoxicity. Plant‐derived bioactive compounds have recently attracted a great deal of attention in the field of PCa treatment due to their potent effects on several molecular targets and synergistic effects with anti‐PCa drugs. This review emphasizes the molecular mechanism of phytochemicals on PCa cells, the synergistic effects of compound‐drug interactions, and stem cell targeting for PCa treatment. Some potential compounds, such as curcumin, phenethyl‐isothiocyanate, fisetin, baicalein, berberine, lutein, and many others, exert an anti‐PCa effect via inhibiting proliferation, metastasis, cell cycle progression, and normal apoptosis pathways. In addition, multiple studies have demonstrated that the isolated natural compounds: d‐limonene, paeonol, lanreotide, artesunate, and bicalutamide have potential synergistic effects. Further, a significant number of natural compounds effectively target PCa stem cells. However, further high‐quality studies are needed to firmly establish the clinical efficacy of these phytochemicals against PCa.
A rare case of lipoid pneumonia mimicking lung malignancy on radiological imaging: A case report
Authors: Yuen Chi Sum , Zhu Tong , Chu Shun Him Colin 
Published: October 2023

AbstractLipoid pneumonia is a rare benign lung disease pathologically characterized by the presence of lipids in the alveoli. It may mimic lung malignancy on radiological imaging. In this case report we present a case of lipoid pneumonia that radiologically manifested as a lung mass and summarize the typical investigation findings and the management of the disease from the literature review to serve as a reminder of and refresh our knowledge of this rare disease entity.
Data Assimilation: A Dynamic Homotopy-Based Coupling Approach
Authors: Reich Sebastian 
Published: October 2023

AbstractHomotopy approaches to Bayesian inference have found wide- spread use especially if the Kullback–Leibler divergence between the prior and the posterior distribution is large. Here we extend one of these homotopy approaches to include an underlying stochastic diffusion process. The underlying mathematical problem is closely related to the Schrödinger bridge problem for given marginal distributions. We demonstrate that the proposed homotopy approach provides a computationally tractable approximation to the underlying bridge problem. In particular, our implementation builds upon the widely used ensemble Kalman filter methodology and extends it to Schrödinger bridge problems within the context of sequential data assimilation.
On the 3D Navier-Stokes Equations with Stochastic Lie Transport
Authors: Goodair Daniel , Crisan Dan 
Published: October 2023

AbstractWe prove the existence and uniqueness of maximal solutions to the 3D SALT (Stochastic Advection by Lie Transport) Navier-Stokes Equation in velocity and vorticity form, on the torus and the bounded domain respectively. In particular we demonstrate the efficacy of Goodair et al. (Existence and Uniqueness of Maximal Solutions to SPDEs with Applications to Viscous Fluid Equations, 2023. Stochastics and Partial Differential Equations: Analysis and Computations, pp.1-64) in showing the well-posedness for both the velocity and vorticity form of the equation, as well as obtaining the first analytically strong existence result for a fluid equation perturbed by Lie transport noise on a bounded domain.
Existence and non-existence results for a semilinear fractional Neumann problem
Authors: Cinti Eleonora , Colasuonno Francesca 
Published: October 2023

AbstractWe establish a priori $$L^\infty $$

L
∞

-estimates for non-negative solutions of a semilinear nonlocal Neumann problem. As a consequence of these estimates, we get non-existence of non-constant solutions under suitable assumptions on the diffusion coefficient and on the nonlinearity. Moreover, we prove an existence result for radial, radially non-decreasing solutions in the case of a possible supercritical nonlinearity, extending to the case $$0<s\le 1/2$$

0
<
s
≤
1
/
2

the analysis started in [7].
Global Perceptions on ERAS® in Pancreatoduodenectomy
Authors: Karunakaran Monish , Roulin Didier , Ullah Shahid , Shrikhande Shailesh V. , De Boer Hans D. , Demartines Nicolas , Barreto Savio George 
Published: October 2023

AbstractBackgroundUptake of ERAS® pathways for pancreatic surgery have been slow and impacted by low compliance.ObjectiveTo explore global awareness, perceptions and practice of ERAS® peri‐pancreatoduodenectomy (PD).MethodsA structured, web‐based survey (EPSILON) was administered through the ERAS® society and IHPBA membership.ResultsThe 140 respondents included predominantly males (86.4%), from Europe (45%), practicing surgery (95%) at academic/teaching hospitals (63.6%) over a period of 10–20 years (38.6%). Most respondents identified themselves as general surgeons (68.6%) with 40.7% reporting an annual PD volume of 20–50 cases, practicing post‐PD clinical pathways (37.9%), with 31.4% of respondents auditing their outcomes annually. Reduced medical complications, cost and hospital length of stay, and improved patient satisfaction were perceived benefits of compliance to enhancing‐recovery. Multidisciplinary co‐ordination was considered the most important factor in the implementation and sustainability of peri‐PD ERAS® pathways, while reluctance to change among health care practitioners, difficulties in data collection and audit, lack of administrative support, and recruitment of an ERAS® dedicated nurse were reported to be important barriers.ConclusionsThe EPSILON survey highlighted global clinician perceptions regarding the benefits of compliance to peri‐PD ERAS®, the importance of individual components, perceived facilitators and barriers, to the implementation and sustainability of these pathways.
Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use
Authors: Kovacsova Flora , Folber Frantisek , Weinbergerova Barbora , Stepanova Radka , Kabut Tomas , Tomiska Miroslav , Krejci Marta , Mayer Jiri 
Published: October 2023

AbstractSince 2006, combined graft-versus-host disease (GVHD) prophylaxis with ATG Grafalon has been our department’s base of peri-transplant supportive care. This recent retrospective study included 398 patients who underwent their first allogeneic hematopoietic stem cell transplantation after receiving a defined dose of ATG Grafalon. Our observations recorded reduced incidence of severe acute and chronic GVHD without negative impact on overall survival in a nonselected group with standard and uniform GVHD prophylaxis.
Prevalence, demographic and spatial distribution of treated epilepsy in France in 2020: a study based on the French national health data system
Authors: Coste Joël , Mandereau-Bruno Laurence , Carcaillon-Bentata Laure , Mikaeloff Yann , Bouilleret Viviane 
Published: October 2023

Abstract
Background
Although still incomplete, the epidemiology of epilepsy shows substantial variations in the burden of the condition according to demographic, social and territorial characteristics. This study aimed to estimate the prevalence of treated epilepsy and to investigate its demographic and spatial distribution in 2020 in France, a country where the nationwide epidemiological situation of the condition remains largely unknown.

Methods
We used the French national health data system, which covers nearly the entire population residing in France (over 67 million of inhabitants in metropolitan and overseas departments). Prevalent cases were identified using long-term disease status, hospitalisation for epilepsy (ICD-10 codes G40 or G41), and reimbursements for antiseizure medications and electroencephalograms.

Results
In 2020, we identified 685,122 epilepsy cases, corresponding to an overall prevalence of 10.2 per 1000 inhabitants [95% confidence interval 10.1–10.2], with similar rates in men and women. Estimates were found to increase with age, with an accelerated rise in the second half of the life, which occurred earlier in men than in women. We observed a monotonic gradient of variation with socio-economic deprivation (in non-military metropolitan subjects aged 18–54 years) as well as territorial heterogeneity, with the mountainous centre of France as well as some French overseas departments having the highest prevalence.

Conclusions
Our results revise upwards the estimation of epilepsy prevalence in France, showing that it now ranks among the highest in developed countries. Our study also confirms the important socio-territorial heterogeneity of the condition that reflects health inequalities in this country.
Photovoltaic system fault detection techniques: a review
Authors: El-Banby Ghada M. , Moawad Nada M. , Abouzalm Belal A. , Abouzaid Wessam F. , Ramadan E. A. 
Published: October 2023

AbstractSolar energy has received great interest in recent years, for electric power generation. Furthermore, photovoltaic (PV) systems have been widely spread over the world because of the technological advances in this field. However, these PV systems need accurate monitoring and periodic follow-up in order to achieve and optimize their performance. The PV systems are influenced by various types of faults, ranging from temporary to permanent failures. A PV system failure poses a significant challenge in determining the type and location of faults to quickly and cost-effectively maintain the required performance of the system without disturbing its normal operation. Therefore, a suitable fault detection system should be enabled to minimize the damage caused by the faulty PV module and protect the PV system from various losses. In this work, different classifications of PV faults and fault detection techniques are presented. Specifically, thermography methods and their benefits in classifying and localizing different types of faults are addressed. In addition, an overview of recent techniques using different artificial intelligence tools with thermography methods is also presented.
Product life cycles, product innovation and firm growth
Authors: Murakami Hiroki 
Published: October 2023

AbstractThis paper studies research and development (R &D) for product innovation of firms faced with “product life cycles.” We represent the concept of product life cycles with bounded revenue and profit functions and describe R &D for product innovation as an activity to control the “birth rate of a new product” (i.e., the probability of product innovation). We then derive the optimal level of R &D, corresponding to the optimal birth rate of a new product, and show that the growth rate of the firm’s expected total revenue converges to the optimal birth rate of a new product in the long run.
Efficacy of ethyl-4-bromophenyl carbamate on different Rhipicephalus microplus stages implanted in cattle
Authors: Iturbe-Requena Sandra Lizeth , Cuenca-Verde César , Prado-Ochoa María Guadalupe , Vázquez-Valadez Víctor Hugo , Muñoz-Guzmán Marco Antonio , Angeles Enrique , Alba-Hurtado Fernando 
Published: October 2023

AbstractThe effect of ethyl-4-bromophenyl carbamate on different Rhipicephalus microplus stages implanted in cattle was evaluated using the pen test with infestation chambers. Twelve steers were distributed into four groups (n = 3), each with four chambers (12 chambers per group), where approximately 1,000 R. microplus larvae were placed in each chamber. The chambers of the first group were sprayed with a solution of ethyl-4-bromophenyl carbamate (0.668 mg/mL) on day 2 post-infestation (PI) (exposed larvae). The chambers of the second group were sprayed with the same solution on day 8 PI (exposed nymphs), and the chambers of the third group were sprayed on day 16 PI (exposed adults) with the same solution. The chambers of the fourth group were used as controls. The percentages of engorged females, egg laying, egg production and egg hatching were evaluated in all groups. The percentage of cumulative reduction of hatched larvae was 98.3, 96.1 and 94.4% when larvae, nymph and adult stages were treated, respectively. The average cumulative reduction of hatched larvae, considering the three treated stages, was 96.3%, whereby the reproductive potential of this tick was drastically reduced. In conclusion, ethyl-4-bromophenyl carbamate acted as an ixodicide (lethal effect) when larval stages were sprayed and as a growth regulator when nymphal and adult stages were sprayed. The sum of these effects had a direct impact on the efficacy of the product in the pen test, and future studies will indicate the potential use of this product for tick control.
Expert knowledge–based system for risk assessment of the occurrence of Amyloodinium ocellatum in semi-intensive fish farms
Authors: Gutiérrez-Estrada Juan Carlos , de la Rosa-Lucas Ignacio , Pomares-Padilla Alejandro , Pulido-Calvo Inmaculada 
Published: October 2023

AbstractThe implementation of a system to assess the risk of Amyloodinium ocellatum occurrence in rearing ponds in fish farms located in southern Spain is a fundamental aspect to ensure the economic viability of these facilities. For this purpose, a computer program (called Amy) for Windows PCs and an application for mobile devices (AmyAPP), based on the Android operating system, were developed integrating transformation functions and weightings associated with environmental parameters and fish behavioural factors from which it is possible to estimate the level of risk of occurrence of A. ocellatum. The weights for each of the environmental parameters and behavioural factors were estimated from the responses of a panel of experts (the fish farmers) using a Delphi methodology. The results indicate that, under operational validation, Amy/AmyAPP responses were statistically sensitive to the occurrence of A. ocellatum outbreaks in sea bream (Sparus aurata) and sea bass (Dicentrarchus labrax) rearing ponds.
Associations between Family Routines, Family Relationships, and Children’s Behavior
Authors: Hosokawa Rikuya , Tomozawa Riho , Katsura Toshiki 
Published: October 2023

AbstractConsistent daily routines are associated with children’s well-being. Family routines provide both a predictable structure to guide behavior and an emotional environment that supports development. Enforcing family routines, improving family relationships, and creating a healthy home environment are necessary to maintain children’s psychosocial health. This study examined the associations between family routines, family relationships, and elementary school children’s behavior. Parents of 1515 third-grade students (8–9 years old) completed a self-administered questionnaire in Japan in 2017. We conducted a path analysis to examine the associations between the predictor variable of family routines, the mediating variable of family relationships, and the criterion variable of children’s behavior. A total of 717 valid responses were included in the analysis. The results showed that family routines were significantly related to children’s behavior (internalizing problem behaviors, externalizing problem behaviors, and prosocial behaviors) through family relationships (cohesiveness, expressiveness, and conflict). Family routines were positively associated with cohesiveness and expressiveness, and negatively associated with conflict. Cohesiveness was negatively associated with externalizing problem behaviors. While expressiveness was negatively associated with internalizing and externalizing problem behaviors, it was positively associated with prosocial behaviors. Conversely, conflict was positively associated with internalizing and externalizing problem behaviors, and negatively associated with prosocial behaviors. Our findings indicate that family routines may protect children’s mental health from the stressors of daily life and foster interpersonal and social competence. Moreover, family routines may stabilize family relationships, reduce children’s problem behaviors, and improve social competence.
Optical characterizations of lightly doped (PbS)1−x Znx thin films influenced by film thickness and annealing temperature for applications in highly intensive radiation systems
Authors: Shokr E. Kh. , Mohamed W. S. , Adam A. G. , Ali H. M. 
Published: October 2023

AbstractThe lightly Zn-doped (PbS)1−x (Zn)x thin films were synthesized by the thermal deposition technique. The structure, morphology, and elemental analyses were carried out by XRD, SEM, and EDS, respectively, and characterised by UV–VIS–NIR spectroscopy. The optical absorption, transmission, and reflection have been studied and analysed. The linear and non-linear parameters have been determined, explained, and compared with the reported results. The effects of Zn-doping, film thickness, and annealing temperature on NLO-parameters have been considered. The better 2.78 × 10–10 and 2.93 × 10–10 esu values of the non-linear refractive index n2 and 3rd-order optical polarizability χ(3), respectively, were attained by (PbS)0.97 (Zn)0.03 film of 150 nm thick annealed at 200 °C.