bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMBALANCE BETWEEN OSTEOSYNTHESIS AND ENDOGENOUS CHRONIC STRESS IN PATIENTS WITH TYPE 2 DIABETES
Authors: Kovalchuk Alla , Zinych Olesia , Prybyla Olha , Kushnareva Natalia , Kovalchuk Volodymyr , Shyshkan-Shyshova Kateryna 
Published: October 2023

Osteocalcin (OC) is a component of phenotypic characteristics, associated with carbohydrate and lipid metabolism. Of interest is the phenotype of type 2 diabetes mellitus (T2DM) without obesity, which may be associated with impaired levels of counter-insulin hormones.
87 patients with T2DM (age 40-78, females/males – 41/46) were examined. Anthropometric parameters and body composition were assessed by the bioelectrical impedance. OC, cortisol, dehydroepiandrosterone sulfate (DHEA-S) blood levels, and the ratio of cortisol/DHEA-S as indicator of the body stress resistance, were measured. Patients were divided into 4 quartiles, depending on the serum OC level, that were significantly different from each other.
Cortisol/DHEA-S ratio was significantly different between the first (lowest OC level) and the fourth quartiles (highest OC level) and between the second, third and fourth quartiles. Visceral fat level was the highest in the first OC quartile, and the lowest in the fourth quartile. When comparing the percentage of total fat between quartiles, no significant difference was found, which may indicate the importance of visceral fat in the formation of metabolic phenotypic changes in the presence of T2DM.
The lowest serum OC level was observed in patients with the greatest intensity of chronic endogenous stress, which is manifested by glucocorticoid function increase according to the cortisol/DHEA-S ratio. It is assumed, that local hypercorticism is the cause of stem cell differentiation into adipocytes, which leads to the formation of a diabetes phenotype with the accumulation of visceral fat without general obesity and the slowing of osteosynthesis with a decrease of the OC level.
PROBLEMS AND PERSPECTIVES OF BUSINESS MANAGEMENT OF MACHINE-BUILDING IN A COMPETITIVE ENVIRONMENT
Authors: Tkachuk Liudmyla , Koval Natalia 
Published: October 2023

The article is devoted to the study of theoretical and applied aspects of enterprise management in a competitive environment. On the basis of existing approaches to the process of managing the competitiveness of industrial enterprises, modern approaches to the effectiveness of such management are considered, and its significance in modern conditions is substantiated. Competitiveness is studied as a fundamental category of the market economy, which directly affects the efficiency of the participants of the competitive environment and ensures the stability of the development of the market mechanism as a whole.
The dynamics and structure of production of machine-building products in Ukraine during 2015-2022 were analyzed, its strategically important role in the country's economy was proven, despite the insignificant share of machine-building products in the total volume of industrial production and the strengthening of exports of raw materials industries. The presence of a crisis in the field of mechanical engineering has been proven, the causes of the crisis have been identified state of machine-building enterprises. The peculiarities of the functioning of the machine-building market in the conditions of military aggression were studied, the main problems and prospects of its development were determined. The main factors of the external and internal environment, which cause negative dynamics of production volumes and sales of mechanical engineering products of Ukraine, are systematized.
Measures for the further effective and competitive development of this market for the long term have been determined, which include the development of effective state programs and strategies for the development of the industry, stimulation of innovative development of enterprises and the introduction of the latest technologies to ensure the possibility of manufacturing high-quality high-tech and knowledge-intensive products.
Concurrent impact of de novo mutations on cranial and cortical development in nonsyndromic craniosynostosis
Authors: Kiziltug Emre , Duy Phan Q. , Allington Garrett , Timberlake Andrew T. , Kawaguchi Riki , Long Aaron S. , Almeida Mariana N. , DiLuna Michael L. , Alper Seth L. , Alperovich Michael , Geschwind Daniel H. , Kahle Kristopher T. 
Published: October 2023

OBJECTIVE
Nonsyndromic craniosynostosis (nsCS), characterized by premature cranial suture fusion, is considered a primary skull disorder in which impact on neurodevelopment, if present, results from the mechanical hindrance of brain growth. Despite surgical repair of the cranial defect, neurocognitive deficits persist in nearly half of affected children. Therefore, the authors performed a functional genomics analysis of nsCS to determine when, where, and in what cell types nsCS-associated genes converge during development.

METHODS
The authors integrated whole-exome sequencing data from 291 nsCS proband-parent trios with 29,803 single-cell transcriptomes of the prenatal and postnatal neurocranial complex to inform when, where, and in what cell types nsCS-mutated genes might exert their pathophysiological effects.

RESULTS
The authors found that nsCS-mutated genes converged in cranial osteoprogenitors and pial fibroblasts and their transcriptional networks that regulate both skull ossification and cerebral neurogenesis. Nonsyndromic CS–mutated genes also converged in inhibitory neurons and gene coexpression modules that overlapped with autism and other developmental disorders. Ligand-receptor cell-cell communication analysis uncovered crosstalk between suture osteoblasts and neurons via the nsCS-associated BMP, FGF, and noncanonical WNT signaling pathways.

CONCLUSIONS
These data implicate a concurrent impact of nsCS-associated de novo mutations on cranial morphogenesis and cortical development via cell- and non–cell-autonomous mechanisms in a developmental nexus of fetal osteoblasts, pial fibroblasts, and neurons. These results suggest that neurodevelopmental outcomes in nsCS patients may be driven more by mutational status than surgical technique.
Use of global sagittal flexibility to predict proximal junctional kyphosis after spinal deformity surgery
Authors: Eaton Ryan G. , Wang Joshua L. , Munjal Vikas , Dhaliwal Joravar , Maggio Dominic , Keister Alexander , Gibbs David , Mallory Noah , Sparks Alexander , Moranville Robert , Xu David S. , Grossbach Andrew J. , Viljoen Stephanus 
Published: October 2023

OBJECTIVE
Sagittal alignment is an important predictor of functional outcomes after surgery for adult spinal deformity (ASD). A rigid spinal column may create a large lever arm that may impact the rate of proximal junctional kyphosis (PJK) after ASD surgery. In this study, the authors sought to determine whether relatively low preoperative global spinal flexibility (i.e., rigid spine) predicts increased incidence of PJK at 1 year after ASD surgery.

METHODS
The authors retrospectively reviewed long-segment thoracolumbar fusions with pelvic fixation performed at a single tertiary care center between October 2015 and September 2020 in patients with a minimum of 1-year radiographic and clinical follow-up. Two cohorts were established on the basis of the optimal value for spinal flexibility, as defined by the absolute difference between the preoperative standing and supine C7 sagittal vertical axes, which the authors termed global sagittal flexibility (GSF). Demographic information, radiographs, various associated complications, and patient-reported outcome measures (PROMs) were analyzed.

RESULTS
Eighty-five patients met the inclusion criteria. Receiver operating characteristic (ROC) analysis using GSF to predict an increase in the proximal junctional sagittal Cobb angle (PJCA) greater than or equal to 10° at 1-year follow-up provided an area under the curve of 0.64 and identified an optimal GSF threshold value of 3.7 cm. Patients with GSF > 3.7 cm were considered globally flexible (48 patients), and those with GSF ≤ 3.7 cm were classified as rigid (37 patients). Rigid patients were noted to have a significantly higher risk of ΔPJCA ≥ 10° at 1-year follow-up (51.4% vs 29.3%, p = 0.049). No changes in the reoperation rates or PROMs based on GSF were observed in the 1- or 2-year postoperative window.

CONCLUSIONS
Based on these retrospective data, preoperative global spinal rigidity portends an independently elevated risk for the development of PJK after ASD surgery. No differences in other complication rates or PROMs data were observed between groups. Data collection was limited to a 2-year postoperative window; therefore, longer follow-up is required to further elucidate the relationship between rigidity and reoperation rates. Based on these retrospective data, flexibility may influence the outcomes of patients with ASD.
TRANSFORMATION OF THE WASATHIYAH ASWAJA AN-NAHDLIYAH PARADIGM TOWARDS MODERATION OF ISLAMIC RELIGIOUS EDUCATION IN INDONESIA
Authors: Hasyim Yusuf , , Supriyono , . Ustadiyah 
Published: October 2023

Abstrak Peran pendidikan agama menjadi bagian yang sangat urgen dalam kontribusinya untuk memberikan pemahaman keagamaan yang rahmatan lil alamin dan memberikan solusi bagi persoalan-persoalan kebangsaan. Persoalan-persoalan yang muncul sebagai akibat dari keragaman masyarakatnya hanya dapat diatasi dan diselesaikan melalui proses pendidikan yang memberikan penawaran perubahan paradigmatik dalam proses dan praktek pendidikan, terutama pendidikan agama. Jenis penelitian merupakan penelitian kepustakaan (library research) yang menggunakan bahan pustaka sebagai sumber utama guna mengetahui bagaimana konsepsi pendidikan wasatiyah dan moderasi beragama. Data penelitian dianalisis menggunakan metode analisis isi (content analysis) untuk mengungkap paradigma pendidikan wasathiyah sebagai perwujudan dari nilai-nilai ahlussunnah wal jama’ah an-Nahdliyah diangkat sebagai sebuah solusi terhadap persoalan-persoalan diskriminasi, ketidakadilan, dan konflik sosial lainnya. Jika kita menilik pada buku-buku pelajaran PAI yang diajarkan di sekolah atau madrasah, maka terdapat peluang yang sangat besar bagi upaya pengembangan nilai-nilai pendidikan berwawasan moderasi beragama (wasathiyah) di Indonesia yang masyarakatnya multikultural. Kata kunci:Paradigma Wasatiyah, Aswaja An-Nahdliyah, Pendidikan Agama Islam
Perbedaan Penerapan Model Pembelajaran Sinektik Dan Direct Instruction Terhadap Keterampilan Menulis Puisi Siswa Kelas IV Sekolah Dasar Gugus Joko Tingkir
Authors: Benu Domina Kristina , Koeswanti Henny Dewi 
Published: October 2023

Menulis puisi sangat penting dimiliki siswa sebagai salah satu sarana untuk menyampaikan ide atau gagasan. Namun fenomena yang terjadi, siswa sering menghadapi kesulitan dalam menulis puisi. Penelitian ini bertujuan untuk mengetahui perbedaan penerapan antara model pembelajaran Sinektik dan Direct Instruction terhadap keterampilan menulis puisi siswa kelas IV Sekolah Dasar Gugus Joko Tingkir dan untuk mengetahui diantara pembelajaran sinektik dan direct instruction yang memiliki tingkat perbedaan lebih tinggi terhadap keterampilan menulis puisi kelas IV Seklah Dasar Gugus Joko Tingkir. Variabel bebas pada penelitian ini adalah model pembelajaran sinektik (X1) dan model pembelajaran direct instruction (X2). Variabel terikat pada penelitian ini adalah keterampilan menulis puisi pada mata pelajaran bahasa Indonesia (Y). Teknik pengambilan data adalah menggunakan teknik tes. Instrumen pengumpulan data yang digunakan adalah lembar tes keterampilan menulis puisi. Pada penelitian ini uji analisis statistik terdiri dari uji normalitas, uji homogenitas, dan uji t atau uji beda rata-rata. Hasil penelitian ini menunjukkan adanya perbedaan keterampilan menulis puisi yang ditunjukkan dengan hasil uji-t posttest sinektik dan direct instruction, diperoleh nilai signifikansi lebih kecil 0,001. Karena nilai Sig (two-sided p) adalah 0,001<0,05 maka disimpulkan bahwa H0 ditolak dan Ha diterima. Yang berarti terdapat perbedaan yang signifikan terhadap keterampilan menulis puisi yang ajarkan dengan model pembelajaran Sinektik dan Direct Instruction Kelas IV Sekolah Dasar Gugus Joko Tingkir.
The effect of COVID-19 vaccines on thyroid function and thyroid autoimmunity
Authors: TAŞKALDIRAN Işılay , ALTAY Feride Pınar , BOZKUŞ Yusuf , TURHAN İYİDİR Özlem , NAR Asli , BAYRAKTAR Nilüfer , BAŞÇIL TÜTÜNCÜ Neslihan 
Published: October 2023

Aims: There have been reports about various thyroid autoimmune events after SARS-CoV-2 vaccinations. There is limited data on the extent to which vaccines for COVID-19 are effective on thyroid autoimmunity. This study investigates how COVID-19 vaccination affects thyroid antibodies and functions in individuals without any thyroid disease history.
Methods: The study evaluated individuals aged 18-65 with no previous COVID-19 history or thyroid disease who had at least two COVID-19 vaccine doses (CoronaVac + Pfizer-BioNTech or Pfizer-BioNTech alone) between October 2021 and October 2022. All participants' thyroid hormone (free triiodothyronine, thyroid-stimulating hormone, and free thyroxine) and thyroid autoantibody (anti-thyroglobulin, antithyroid peroxidase, and TSH receptor antibody) levels were measured.
Results: The study included 92 individuals in total. Thyroid functions and antithyroid antibody levels were found to be in the normal range before the implementation of the SARS-CoV-2 vaccine. Of the study participants, 42 received the Sinovac + BioNTech vaccine, and 50 received the BioNTech vaccine alone. While a decrease in st4 value was observed only in the BioNTech group after vaccination (p=0.007), thyroid dysfunction was not observed in any participant. After vaccination, TRAB positivity was observed in one participant, ANTI-TPO positivity in six participants, and ANTI-TG positivity in eight participants. No statistically significant antibody positivity was detected. No participants with antibody positivity displayed thyroid dysfunction.
Conclusion: Although some positivity in terms of antithyroid antibodies was observed after COVID-19 vaccination, this antibody positivity did not have a statistically significant level, and thyroid dysfunction was not detected in any participant. The COVID-19 vaccine is safe for thyroid function and autoimmunity.
Haccın Şartları Bağlamında Hac Kotasının Değerlendirilmesi
Authors: YILDIRIM Ahmet Hamdi 
Published: October 2023

Allah, insanları dünya hayatında çeşitli sorumluluklarla yükümlü kılmıştır. Bu sorumluluklar, insanların imtihan edilmesi ve ahirette hesap vermesi için önemlidir. Hac ibadeti de bu yükümlülüklerden biridir. Hac, İslam'ın beş temel esasından biri olarak kabul edilir ve Müslümanlar, maddi imkanları elverdiği durumda bu ibadeti yerine getirmekle sorumludurlar.
Ancak zaman içerisinde, seyahat imkanlarının gelişmesi ve ulaşımın kolaylaşmasıyla birlikte hac yapma fırsatı artmıştır. Bu durum, her yıl Mekke'ye hacca gitmek isteyenlerin sayısında büyük artışlara yol açmıştır. Yoğun talep ve sınırlı altyapı imkanları nedeniyle Mekke'de yığılmalar oluşmuş ve bu da ibadetin düzenini ve güvenliğini tehlikeye atmıştır.
Bu zorlukları aşmak ve hac ibadetini düzenli ve güvenli bir şekilde gerçekleştirebilmek için bir çözüm olarak "kota uygulaması" devreye alınmıştır. Hac kotası, her ülkenin Müslümanlarından belirli bir kontenjanın seçilmesi ve bu kontenjan çerçevesinde hac ibadetini gerçekleştirmelerine izin verilmesi anlamına gelir. Bu yöntem, hac ibadetini daha sürdürülebilir ve güvenli hale getirmek amacıyla geliştirilmiştir.
Kota uygulaması, hac ibadetinin düzenini sağlamak, hacıların ihtiyaçlarını karşılamak ve ibadet sırasında güvenliği sağlamak amacıyla önemlidir. Bu uygulama, hac ibadetinin her yıl düzenli ve etkili bir şekilde gerçekleştirilmesini sağlamak için alınmış bir önlemdir.
Bütün bu gerekçelerin yanında hac ibadetini yerine getirmek için kota beklerken ölen bir kişinin durumu tartışma konusu olmuştur. Bu kimse İslam hukukuna göre hac ibadeti ile sorumlu kabul edilir mi edilmez mi?
Tartışmanın temelindeki mesele, kişinin hac vizesine sahip olmasının hac ibadetinin vücub şartı mı, yoksa eda şartı mı olduğu konusundaki görüş ayrılığıdır. Vücub şartı, bir ibadetin farz olabilmesi için gerekli olan şartları ifade ederken, eda şartı ise ibadetin sahih bir şekilde yerine getirilmesi için gereken şartları ifade eder. Hac vizesi durumu da bu açıdan ele alınabilir.
Bu makale, hac vizesinin hukuki boyutunu araştırmayı ve vücub şartı mı, yoksa eda şartı mı olduğu konusunda aydınlatıcı bilgiler sunmayı amaçlamaktadır. Bu bağlamda, hac vizesi beklerken hayatını kaybeden bir Müslümanın, hac ibadetiyle sorumluluk taşıyıp taşımadığı meselesi de ele alınacaktır. Ayrıca, böyle bir durumda Müslüman'ın yerine getiremediği hac ibadetini telafi etmek amacıyla bedel hac vasiyeti yapması gerekip gerekmediği de detaylarıyla ele alınacaktır.
Utilization of chicken manure as organic fertilizer to increase growth and production Elephant grass (Pennisetum purpureum)
Authors: Bouk Gomera , Sinabang Maria Kristina 
Published: October 2023

This study aims to determine the level of growth and production of Pennisetum purpureum which is given organic fertilizer based on chicken manure with different proportions. This research was carried out on land belonging to the Independent Farmers group in Leosama village, Kakuluk Mesak sub-district, Belu Regency, East Nusa Tenggara, which started from March to June 2022. This research was carried out using the experimental method with a Randomized Block Design (RDB) consisting of 4 treatments and 4 replications so that there are 16 experimental plots in total. The treatments tested consisted of: K) Control (without chicken manure); PA) Pennisetum purpureum is given organic fertilizer made from 25% chicken manure; PB) Pennisetum purpureum is given organic fertilizer made from 50% chicken manure; and PC) Pennisetum purpureum fertilized with organic fertilizer made from 75% chicken manure. The results showed that the application of organic fertilizers made from chicken manure had a very significant effect (p<0.01) on the growth of plant height, number of leaves and leaf length as well as the fresh weight and dry weight of Pennisetum purpureum plants. The conclusion of this study is the use of organic fertilizers made from chicken manure up to 75% is the best in increasing the growth and production of Pennisetum
ANALISIS JABATAN SEBAGAI DASAR REKRUTMEN UNTUK PENINGKATAN KINERJA SUPERVISOR (STUDI KASUS DI PT. SUKSES ANUGRAH SEJAHTERA)
Authors: Setiawan Imam 
Published: October 2023

AbstractPT SAS is one of national facility service company in Indonesia which provide services about cleaning service professional, security service, pest control, and handling managing people. The core business service is professional cleaning service. In data that has been collected, show that performance of Supervisor PT. SAS was bad, which caused by recruitment process that is misfit from job analysis.The purpose of this research is to get job analysis design of supervisor PT SAS in order to improving recruitment efectivity. Theory which is used in this research is perfomance theory, recruitment, dan job analysis.Research method which is used in this research is qualitatif descriptive method. Instrument which is used in this research by quesioner, interview, and observation with 360 degrees session, to get comprehensive information in order to make job analysis design of supervisor PT SAS.The results of research is show comprehensive information about job description and job specification which used as a competency model for recruitment process. Comparing between before and after job analysis have done, it shows that information about qualification of supervisor have many contents about skill, knowledge, and attitude. Before job analysis did’nt do, information about qualification of supervisor is only about skill other characteristic
FAKTOR-FAKTOR YANG MEMPENGARUHI NIAT BELI EMAS MELALUI MOBILE BANKING
Authors: Kurniawan Dedi , Maulana Achmad , Shihab Muchsin Saggaff 
Published: October 2023

Tujuan: Tujuan dari penelitian ini adalah untuk menguji pengaruh Persepsi Kegunaan, Persepsi Kemudahan, Sikap, Pengetahuan Produk, Kepercayaan, dan Persepsi Resiko terhadap Niat nasabah pengguna BSI mobile untuk membeli emas online di Bank Syariah Indonesia. Penelitian ini secara khusus mengkaji niat beli emas online di mobile banking. Metode: jenis penelitian kuantitatif dan data dikumpulkan dari 218 nasabah Bank Syariah Indonesia di Kota Palembang menggunakan survei online dan offline. Analisis data: Model persamaan struktural (SEM). Hasil dan diskusi: Studi ini menemukan peran pengetahuan produk dan persepsi risiko berpengaruh signifikan terhadap Niat nasabah pengguna mobile banking untuk membeli emas online di aplikasi mobile banking. Persepsi Kegunaan dan Persepsi Kemudahan berpengaruh signifikan terhadap Sikap. Kesimpulan: Penelitian ini hanya menyelidiki niat membeli emas sebagai salah satu jenis investasi emas secara online di aplikasi mobile banking. Studi ini berkontribusi pada literatur dengan memeriksa peran Persepsi Kegunaan, Persepsi Kemudahan, Sikap, Pengetahuan Produk, Kepercayaan, dan Persepsi Resiko terhadap Niat nasabah pengguna mobile banking untuk berinvestasi emas melalui aplikasi. Hasil penelitian ini menyoroti kebutuhan bank syariah untuk mengedukasi nasabah untuk meningkatkan pengetahuan produk deposan karena risiko dan persepsi nilai dan niat nasabah muslim sangat dipengaruhi oleh pengetahuan produk.
Full Day School di Madrasah Ibtidaiyah Nurul Ummah Kotagede
Authors: Prasetyo Heru 
Published: October 2023

Currently, the madrasah has an important role in fostering students by holding positive and beneficial activities for the future, then the full-day school system emerged which was finally widely applied in Indonesia. This full-day school aims to foster attitudes or morals and form better character in students amid the rampant moral decadence of the nation's children, this program is also accompanied by the provision of religious values because students have a lot of time in the madrasah, so coaching will be easily done by the madrasah. This study aims to determine the implementation of a full-day school that has been implemented by MI Nurul Ummah Kotagede. The type of research used is qualitative research with descriptive methods. Data collection was done by observation and interviews. Data processing and analysis techniques used are data reduction techniques, presentation, and conclusions. The results showed that the implementation of a full-day school at MI Nurul Ummah in the learning process lasted for 9 hours per day. Covering religious activities and other public lessons then complemented by extracurriculars to support the interests and talents of students
[Saat ini madrasah memiliki peran penting dalam membina peserta didik dengan mengadakan kegiatan-kegiatan yang positif dan bermanfaat untuk masa depan, kemudian muncul sistem full day school yang akhirnya diterapkan secara luas di Indonesia. Sekolah sehari penuh ini bertujuan untuk membina sikap atau akhlak dan membentuk karakter yang lebih baik pada siswa di tengah maraknya dekadensi moral anak bangsa, program ini juga dibarengi dengan pemberian nilai-nilai religi karena peserta didik memiliki banyak waktu di madrasah , sehingga pembinaan akan mudah dilakukan oleh pihak madrasah. Penelitian ini bertujuan untuk mengetahui implementasi full day school yang telah dilaksanakan oleh MI Nurul Ummah Kotagede. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan metode deskriptif. Pengumpulan data dilakukan dengan observasi dan wawancara. Teknik pengolahan dan analisis data yang digunakan adalah teknik reduksi data, penyajian dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa pelaksanaan full day school di MI Nurul Ummah dalam proses pembelajaran berlangsung selama 9 jam per hari. Meliput kegiatan keagamaan dan pelajaran umum lainnya kemudian dilengkapi dengan ekstrakurikuler untuk menunjang minat dan bakat siswa]