bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caregivers’ experiences of being asked about adverse childhood experiences and receiving support from an integrated health and social care hub: a qualitative study
Authors: Kabir Ashraful , Loveday Sarah , Hiscock Harriet , Bosward Rebecca , Ebbett Wilhelmina , Liu Hueiming , White Natalie , Chen Lingling 
Published: February 2025

ObjectivesAdverse childhood experiences (ACEs) are significant contributors to the burden of disease and remain a serious concern for the health and wellbeing of children in Australia. To address ACEs, we co-designed and implemented two integrated health and social care hubs (Child and Family Hubs [CFHs]). This study explores the experiences of caregivers who received care from the CFHs, including the way they were asked about ACEs and the services offered to address identified ACEs.DesignA qualitative study design was used. Using a semistructured interview guide, 29 in-depth interviews were conducted with caregivers of children who were experiencing a range of adversities, including maltreatment and household dysfunction, child neglect, parent mental illness, domestic violence, family conflict, community dysfunction, discrimination, poverty or financial hardship. A thematic analysis approach was used to analyse textual data. Triangulation of investigators and sources of data improved validation of the findings. NVivo (V.12) was used to organise, index and retrieve data.SettingsThis study was conducted in two Child and Family Hubs (CFHs) in Australia—IPC Health, Wyndham Vale, Melbourne, and Marrickville Health Centre, Sydney, between May and October 2023.ParticipantsParticipants (n=29) were the caregivers of children living with adverse childhood experiences (ACEs).ResultsFour themes were identified which reflected the caregivers’ experiences of being asked about adversities and how they linked to the support and services both in the CFHs and outside the CFH. These themes were as follows: (i) trusting relationships are fundamental; (ii) expectations play a role in talking about adversities; (iii) barriers to open discussion of adversities and (iv) barriers to accessing services.ConclusionsConsultations between caregivers and hub practitioners can effectively identify and address ACEs despite certain barriers. Establishing a trusting relationship where caregivers feel heard and supported is vital, highlighting the hub model’s potential impact in Australia and similar contexts. Enhancing consultation duration, and service availability and accessibility may further improve caregivers’ experiences in identifying and addressing adversity.
Chronic postsurgical pain and transitional pain services: a narrative review highlighting European perspectives
Authors: Moka Eleni , Aguirre José Alejandro , Sauter Axel R , Lavand’homme Patricia 
Published: February 2025

Background/ImportanceChronic postsurgical pain (CPSP) is a significant, often debilitating outcome of surgery, impacting patients’ quality of life and placing a substantial burden on healthcare systems worldwide. CPSP (pain persisting for more than 3 months postsurgery) leads to both physical and psychological distress. Recognized as a distinct chronic pain entity in International Classification of Diseases, 11th Revision, CPSP enables better reporting and improved management strategies. Despite advancements in surgical care, CPSP remains prevalent, affecting 5%–85% of patients, with higher rates following thoracotomies, amputations, mastectomies and joint replacements.ObjectiveThe acute to chronic pain transition involves complex interactions between peripheral and central mechanisms, with central sensitization playing a key role. Identifying high-risk patients is crucial for prevention, with factors such as surgical type, nerve injury, neuropathic elements in acute postoperative pain, and psychosocial conditions being significant contributors.Evidence reviewCurrent pain management strategies, including multimodal therapy and regional anesthesia, show limited effectiveness in preventing CPSP. Neuromodulation interventions, though promising, are not yet established as preventive modalities.FindingsTransitional pain services (TPSs) offer a comprehensive, multidisciplinary approach to managing CPSP and reducing opioid dependence, addressing both physical and psychosocial aspects of functional recovery. While promising results have been seen in Canada and Finland, TPSs are not yet widely implemented in Europe. There is also growing interest in pain biomarkers, through initiatives such as the A2CPS program, aiming to improve CPSP prediction and develop targeted interventions.ConclusionsFuture research should focus on large-scale studies integrating various factors to facilitate CPSP prediction, refine prevention strategies and reduce its long-term impact.
Finding excesses in model parameter space
Authors: Chathirathas Kierthika , Ferber Torben , Kahlhoefer Felix , Morandini Alessandro 
Published: February 2025

Abstract
Simulation-based inference (SBI) makes it possible to infer the parameters of a model from high-dimensional low-level features of the observed events. In this work we show how this method can be used to establish the presence of a weak signal on top of an unknown background, to discard background events and to determine the signal properties. The key idea is to use SBI methods to identify events that are similar to each other in the sense that they agree on the inferred model parameters. We illustrate this method for the case of axion-like particles decaying to photons at beam-dump experiments. For poor detector resolution the diphoton mass cannot be reliably reconstructed, so there is no simple high-level observable that can be used to perform a bump hunt. Since the SBI methods do not require explicit high-level observables, they offer a promising alternative to increase the sensitivity to new physics.
Further study of $$c\bar{c}c\bar{c}$$ system within a chiral quark model
Authors: Wu Yuheng , Liu Xuejie , Ping Jialun , Huang Hongxia , Tan Yue 
Published: February 2025

Abstract
Inspired by the recent ATLAS and CMS experiments on the invariant mass spectrum of

$$J/\psi J/\psi $$

J
/
ψ
J
/
ψ

, we systematically study the

$$c\bar{c}c\bar{c}$$

c

c

¯

c

c

¯

system of

$$J^{P}=0^{+}$$

J
P

=

0
+

. In the framework of chiral quark model, we have carried out bound-state calculation and resonance-state calculation respectively by using Real-scaling method. The results of bound-state calculation show that there are no bound states in the

$$c\bar{c}c\bar{c}$$

c

c

¯

c

c

¯

with

$$0^{+}$$

0
+

system. The resonance-state calculation shows that there are four possible resonances: R(6923), R(6996), R(7060) and R(7159). R(6923) and R(7159) are experimental candidates for X(6900) and X(7200), whose main decay channel is

$$J/\psi J/\psi $$

J
/
ψ
J
/
ψ

. It is important to note that the another major decay channel of R(7159) is

$$\chi _{c0} \chi _{c0}$$

χ

c
0

χ

c
0

, and the

$$\chi _{c0} \chi _{c0}$$

χ

c
0

χ

c
0

is also the main decay channel of R(6996), R(7060). Therefore, we propose to search experimentally for these two predicted resonances in the

$$\chi _{c0} \chi _{c0}$$

χ

c
0

χ

c
0

invariant mass spectrum.
From Human Intervention to Human Involvement: A Critical Examination of the Role of Humans in (Semi-)Automated Administrative Decision-Making
Authors: Haitsma Lucas , Brink Barbara 
Published: February 2025

In view of recent scandals, evolving regulatory demands, and changing perceptions of human involvement in automated systems, this study examines how the role of humans in semi-automated administrative decision-making (AADM) is conceptualized in academic literature. We conducted a qualitative systematic literature review from the public administration, law and socio-technological fields, to critically examine what is understood as human involvement in AADM.
Our findings suggest that the literature largely focuses on human intervention in AADM, where individual decision makers either review automated outputs before making a decision (human-in-the-loop) or review automated decisions (human-out-of-the-loop). However, a broader scope on human involvement in AADM – which also includes system designers (human-in-control) and monitoring and supervisory roles responsible for ongoing oversight (human-on-the-loop) is crucial to fully capture the human-machine dynamic in AADM.
These insights can be used to advance the understanding of the human-automation interaction in AADM through a more comprehensive conceptualization of human involvement. This broader, governance-oriented, view has the potential to optimize the interrelationship between human involvement and automation, ultimately improving accountability, effectiveness, and adaptability in AADM. New legislation underscores the importance of meaningful human involvement beyond isolated review points, encompassing design and ongoing oversight.
Incidence of Episiotomy in Kasr Alainy OBGYN Hospital in Cairo, Egypt: A Cross‐Sectional Study
Authors: Sadek Omar , Fahim Nora , Yehia Hana , Elmashad Mariam , Alaa Farah , Rakha Abdulrahman , Khaled Ahmad , Sherif Nadine 
Published: February 2025

Objective: This study aims to determine the incidence of episiotomy in Kasr Alainy OBGYN Hospital in Cairo, Egypt. The objectives include identifying and examining the reasons behind the notably higher episiotomy rates in this region, and assessing the relevance of general WHO recommendations in lower‐middle‐income countries.Design: This observational cross‐sectional study was conducted between March 1, 2022 and June 30, 2022, to determine the incidence of episiotomy among vaginal deliveries in the hospital.Setting: Data was collected from patient charts at Kasr Alainy OBGYN Hospital in Cairo, Egypt.Patient Sample: The total number of patient charts inspected was 1731, of which 1545 met the inclusion criteria.Methods: Data were manually collected from patient hospital records at the end of each day, and entered into a standardized data‐collection form. The data collected was then statistically analyzed using SPSS.Main Outcome Measures: The overall incidence of episiotomy was 64%.Results: When analyzed by gravidity, the incidence was found to be 97% in primigravida patients and 52% in multigravida patients. Additionally, several other associated factors were examined.Conclusions: The incidence of episiotomy at Kasr Alainy OBGYN Hospital surpasses the rate recommended by the WHO. Our observations suggest that the primary contributing factors to this elevated incidence include perineal rigidity, the duration of labor, and local practice standards. Further research is recommended to explore the impact of perineal massage before and during delivery, as well as patients’ lifestyle factors, on the necessity for episiotomy.
The Risk of Haematoma and Venous Thrombosis Associated With Thromboprophylaxis Use in Breast Cancer Surgery: A Meta‐Analysis and Systematic Review
Authors: Dhannoon Amenah , Balasubramanian Ishwarya , Dhannoon Ali A. , Butt Abeeda , Hill Arnold D. K. 
Published: February 2025

Background: The routine use of venous thromboembolism (VTE) prophylaxis in breast cancer surgery has caused substantial polarity among breast cancer surgeons across the globe. The aim of this study is to assess the use of VTE prophylaxis in breast cancer surgery outcomes.Methods: A comprehensive electronic search was undertaken of all comparative studies that described the role of VTE prophylaxis in breast cancer surgery. Studies that reported on postoperative outcomes between patients who received VTE prophylaxis (prophylaxis) and those who did not (no prophylaxis) were included in the review. A meta‐analysis using random‐effect model was used to analyse key outcomes, with data presented as odd ratio (OR).Results: A total of 2470 patients from 6 studies were included in this study. Among these patients, 60.9% (n: 1504) received prophylaxis. The haematoma rate in this study is 0.05% (n: 133). The incidence of haematoma was significantly associated with the use of prophylaxis (6.85% versus 3.11%, p : 0.001). Surgical intervention for haematomas was also significantly associated in this group (3.15% versus 0.83%, p : 0.004). However, there was no difference in VTE events between both groups (0.26% versus 0.36%, p : 0.88).Conclusions: The use of VTE prophylaxis in breast cancer surgery is associated with increased haematomas without any benefit in preventing VTE events. Future studies that examine the use of risk assessment tools for VTE prophylaxis in high risk patients may be beneficial.
Autonomous Epinephrine Release by KCNJ5 Mutation Drives Familial Thoracic Aortic Aneurysm and Dissection
Authors: Duan Yanyu , Wu Chenglong , Lai Zhenghong , Yuan Qunxing , Hu Naixing , Liu Shaoqiang , Liu Ziyou 
Published: February 2025

BACKGROUND:
The pathophysiology of familial thoracic aortic aneurysm and dissection (TAAD) is linked to genetic variants that affect aortic components. Although hypertension is a risk factor for TAAD, the precise genetic link remains unclear.

METHODS:
A family with autosomal dominant TAAD complicated by hypertension was studied to identify candidate mutations. The effect of the identified mutation on TAAD development was investigated using a CRISPR-Cas9–generated knock-in mouse model to elucidate the mechanism underlying hypertension-induced TAAD.

RESULTS:

The
KCNJ5 p.R242Q
mutation was identified in the family and met the criteria for cosegregation, rarity, and conservation. Utilizing our mouse model, we observed that a significant proportion of heterozygous mice with the mutation displayed dilated thoracic aortas. The mutation’s allele dose was positively correlated with TAAD incidence following β-aminopropionitrile monofumarate treatment. Pathological changes in the thoracic aorta, including collagen deposition and dilation, elevated transforming growth factor-β activity, and extracellular matrix remodeling, were associated with hypertension. Furthermore, the mutation was found to induce lifelong isolated systolic hypertension, attributable to autonomous epinephrine secretion from the adrenal medulla. Unlike wild-type, mutated
KCNJ5
was highly expressed in the adrenal medulla instead of the adrenal cortex. Treatment with the adrenergic β–receptor blocker propranolol reduced systolic hypertension and mitigated TAAD in the heterozygous mice.

CONCLUSIONS:

Familial TAAD may stem from
KCNJ5
dysfunction in the G-protein–coupling domain, causing isolated systolic hypertension via increased epinephrine secretion and disruption of thoracic aortic homeostasis. These findings establish a genetic link between systolic hypertension and TAAD.
MYSM1 Mediates Cardiac Parthanatos and Hypertrophy by Deubiquitinating PARP1
Authors: Zhong Xin , Xu Jianjiang , Shi Xiaowen , Lyu Yiting , Qian Yuanyuan , Fang Zimin , Wang Zixuan , Xing Jincheng , Ye Bozhi , Xu Jiajun , Han Jibo 
Published: February 2025

BACKGROUND:
Cardiac hypertrophy constitutes the primary pathological basis for heart failure and exerts a considerable influence on morbidity and mortality. Deubiquitinating enzymes are crucial regulators of protein degradation and play a pivotal role in cardiac pathophysiology. This study aimed to clarify the involvement of a deubiquitinating enzyme, MYSM1 (Myb-like, SWIRM, and MPN domains 1), in cardiac hypertrophy and to explore the underlying mechanism.

METHODS:

Cardiac hypertrophy was developed by angiotensin II or transverse aortic constriction surgery. Cardiomyocyte-specific knockdown of MYSM1 was accomplished using the adeno-associated virus serotype 9-
cTNT
-
Mysm1
-shRNA. Co-immunoprecipitation combined with liquid chromatography-tandem mass spectrometry analysis was utilized to identify potential substrates of MYSM1.

RESULTS:
First, we discovered that the expression of MYSM1 increases during cardiac hypertrophy. MYSM1 knockdown mitigated cardiac dysfunction and hypertrophy after angiotensin II administration. Cardiomyocyte-specific knockdown of MYSM1 with adeno-associated virus serotype 9 alleviated myocardial dysfunction and hypertrophy caused by transverse aortic constriction surgery. Through co-immunoprecipitation and LC-MS, poly (ADP-ribose) polymerase 1 (PARP1) was identified as a potential substrate protein of MYSM1. PARP1 initiates a novel form of programmed cell death termed parthanatos, which is characterized by excessive PARylation, nuclear translocation of AIF, and depletion of nicotinamide adenine dinucleotide. MYSM1 deubiquitinates and stabilizes PARP1 in an MPN domain-dependent manner. In addition, MYSM1 mediates cardiac hypertrophy through PARP1-dependent cardiomyocyte parthanatos.

CONCLUSIONS:
This study identified the role of the MYSM1-PARP1 axis in mediating cardiac hypertrophy and suggested that MYSM1 is a promising pharmacological target for the treatment of cardiac hypertrophy.
Sight-×-Site
Authors: Han Eugene 
Published: February 2025

Abstract
This historical perspective identifies theoretical and graphical parallels between two unlikely accomplices: the mid-twentieth-century multidisciplinary movement the Situationist International, and developments in the psychological study of eye movements. Both schools of thought approach the ostensible objectivity of the visible world through a deconstructed and personalized interpretation made possible by our perception. Especially in regard to aesthetics, our perceptual biases enable an agency through which everyone can participate and ultimately enrich the dialogue that provisions art with meaning. Diagrams of eye-tracking studies inspired by early Situationist graphics highlight the piecemeal and constructive nature of our perception. In the context of unprecedented AI image generation, with aesthetic creativity itself being questioned, the text offers a graphic-based reminder of the value and creativity of our perception.
Natural feeding of the freshwater crab Dilocarcinus pagei Stimpson, 1861 (Decapoda: Trichodactylidae) in the floodplain of the Araguari River, southeastern Brazil
Authors: Barboza Ana Cláudia Garcia , Nogueira Caio Santos , Bueno Alessandra Angélica Pádua , Jacobucci Giuliano Buzá 
Published: February 2025

Abstract
Freshwater decapods, such as the crabs in the family Trichodactylidae, are key components of benthic food webs, but research on their trophic ecology is limited. This study aimed to investigate variations in the natural diet of the freshwater crab Dilocarcinus pagei in the Araguari River, Brazil. We analyzed demographic groups and seasonal differences in stomach fullness, volume, and frequency of occurrence of various dietary items. Our results revealed that stomach fullness varied among demographic groups, with adult females showing lower levels and juvenile females showing higher levels. Analysis of stomach contents identified 12 types of items, including unidentified animals, detritus, sand, plastic filaments, and molluscs. Juvenile females showed a higher consumption of plant tissue, while only adult males and juveniles showed a consumption of molluscs. Plant tissue and detritus (digested material) were the most frequent items. These findings reveal the feeding habits of D. pagei in the sampling area, highlighting the influence of demographic groups and seasonal variations on their diet, including the consumption of plant tissue, predation on molluscs, and ingestion of microplastics.
Developing Strategic Foresight among Youth Ministers: A Proposal for Learning a New Leadership Competency
Authors: Goh Gary 
Published: February 2025

Abstract
The world is changing in unprecedented ways in the digital age. Advances in information technology have revolutionized the global flow of information, goods, and services, increasing the speed, extent, and impact of change in human societies like never before. Youth ministers must learn to adapt to evolving new norms and expectations to remain relevant to those they serve. This article argues for strategic foresight as a critical leadership competency to better anticipate and navigate future changes. The argument is organized around three guiding questions:
1. Why is there a need for strategic foresight?
2. What is strategic foresight, and what is it not?
3. How can strategic foresight be developed?
The significance of this article lies in its advocacy for developing a new leadership competency among youth ministers to cultivate both an acute awareness of social change and the capacity for future-ready ministry.
التكوين الثقافيّ للحلم في الرواية العربيّة
Authors: العجيلي شهلا 
Published: February 2025

المستخلص
‫يدرس البحث طريقة صناعة الحلم في النصوص الروائيّة العربيّة، وانتقاء مكوّناته، وأسلبته، وتوظيفه ليصير بنية دالّة على المرجعيّة الثقافيّة التي ينتمي إليها النصّ. يفترض البحث أنّ الحلم، إذا ما بقي محدودًا بحدود الثقافة، واتّخذ من مكوّناتها وتأويلاتها مرجعيّة له، فسيُدرَج ضمن قائمة المفردات الثقافيّة، النسقيّة غالبًا، كالملابس، والطعام، واللغة، والشعائر. يتفحّص البحث أيضًا طريقة صناعة الحلم في شكل بنية فنّيّة مبتورة عن المرجعيّة، لتقتصر وظيفته على تكوين العلاقات النصّيّة غير السياقيّة في الرواية. ويدرس البحث الاحتمالين المذكورين في ظلّ كلّ من الرؤية التأويليّة في الثقافة العربيّة الإسلاميّة، والرؤية الحداثيّة لمدرسة التحليل النفسيّ عند كارل يونغ (Carl Jung)، وإريك فروم (Erich Fromm)، ويتوصّل إلى نتائجه عن طريق دراسة خمسة نصوص روائيّة عربيّة، يشكّل الحلم لها إمّا علّة أو وظيفة، وهي: قصّة حلم لهاني النقشبندي، وعام الفيل لليلى أبو زيد، وفاكهة للغربان لأحمد زين، ومنامات لجوخة الحارثي، وصمت الطواحين ليوسف أبو ريّة. يتعرّف البحث إلى المكوّنات الثقافيّة للحلم عن طريق دراسة كلّ من البنية والرمز في علاقته مع المرجعيّة الثقافيّة، وينظر في توجيه الروائيّ الخيالَ نحو كسر العلاقة بين الرمز وسياقه الثقافيّ، أو في إحجامه عن تلك المغامرة.‬
Structural Substitution Rather Than Efficiency Improvement in Thermal Power Sector Achieved by China’s Pilot Carbon Markets
Authors: Qian Haoqi , Gong Yanran , Wang Shouyang , Wu Libo 
Published: February 2025

Thermal power sector plays a crucial role in achieving China’s climate mitigation targets due to its large contribution to the nation’s overall carbon emissions. This study constructs a unique nationwide unit-level dataset containing more than 1,000 coal-fired power units (CPUs) to evaluate the heterogeneous effects of China’s pilot Emission Trading Schemes (ETSs). Results disclose that the pilot ETSs generate a prominent reduction effect of coal consumption through electricity production shrinkage and output substitution among generation units. CPUs’ energy efficiencies have barely improved in the short run and even have been worsened in the longer term. From the market perspective, active tradings, higher prices and stringent benchmark standards are conducive to efficiency improvement but also bring uncertain impacts on coal abatement. Stringent benchmark standards and China’s administrative dispatching system contribute and strengthen the structural substitutions toward high-capacity CPUs. Finally, counterfactual simulation shows that the structural substitutions result in uneven distributions of air pollution co-benefits brought by the pilot ETS. JEL Classification: C21, Q48, Q54