bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between perseverative thinking, proactive control, and inhibition in psychological distress: a study in a women’s cohort
Authors: Mattioni Lorenzo , Spada Marcantonio M. , Ferri Francesca , Sestieri Carlo 
Published: November 2023

AbstractCognitive control is a core feature of several mental disorders. A recent account poses that health problems may derive from proactive forms of cognitive control that maintain stress representation over time. The working hypothesis of the present study is that psychological distress is caused by the tendency to select a particular maladaptive self-regulation strategy over time, namely perseverative thinking, rather than by transient stimulus–response patterns. To test this hypothesis, we asked 84 women to carry out a battery of standardized questionnaires regarding their tendency to undertake perseverative thinking and their level of psychological distress, followed by cognitive tasks measuring the tendency to use proactive versus reactive control modality and disinhibition. Through a series of mediation analyses, we demonstrate that the tendency to use proactive control correlates with psychological distress and that this relation is mediated by perseverative thinking. Moreover, we show that the relation between low inhibitory control and psychological stress is more strongly mediated by perseverative thinking than impulsiveness, a classical construct that focuses on more transient reactions to stimuli. The present results underline the importance of considering psychological distress as the consequence of a maladaptive way of applying control over time, rather than the result of a general deficit in cognitive control abilities.
Circ_ZNF778_006 promoted ESCC progression by upregulating HIF-1α expression via sponging miR-18b-5p
Authors: Si Xianzhe , Su Xincheng , Lin Weijie , Xu Jie , Huang Wenbo , Chen Feng , Huang Zhijun , Lin Jianqing , Chen Zhiyao 
Published: November 2023

AbstractIn multiple malignant tumors, circular RNAs (circRNAs) are believed to play a crucial role. Our prior results demonstrated that circ_ZNF778_006 was significantly increased in esophageal squamous cell carcinoma (ESCC) tissues, but the roles of circ_ZNF778_006 in ESCC is still not clear. The expression of circ_ZNF778_006 was compared in different pathological grades of ESCC. And the expression levels of circ_ZNF778_006, miR-18b-5p, HIF-1α were analyzed by qRT-PCR and Western blot, respectively. Plasmid transfection techniques were applied to prepare ESCC cells with silenced or overexpressed genes (CircZNF778_006, miR-18b-5p). The CCK8 kit was used to determine cell proliferation, and the Transwell assay was used to measure the migration and invasion. The effects of circ_ZNF778_006 on tumor growth was investigated in vivo. Furthermore, luciferase reporter gene assay and RNA-binding protein immunoprecipitation (RIP) were performed to verify the targeting relationship between miR-18b-5p and circZNF778_006, miR-18b-5p and HIF-1α. The expression of circ_ZNF778_006 was positively correlated with pathological grade in ESCC. Circ_ZNF778_006 significantly inhibited sensitivity to 5-fluorouracil & cisplatin. It could promote the proliferation, invasion, migration in ESCC cells and accelerated tumor growth in vivo. Furthermore, circ_ZNF778_006 could upregulate the expression of HIF-1α via sponing miR-18b-5p. Circ_ZNF778_006 promoted ESCC progression by upregulating HIF-1α expression via sponging miR-18b-5p.
Hippocampal interneuronal dysfunction and hyperexcitability in a porcine model of concussion
Authors: Ulyanova Alexandra V. , Adam Christopher D. , Cottone Carlo , Maheshwari Nikhil , Grovola Michael R. , Fruchet Oceane E. , Alamar Jami , Koch Paul F. , Johnson Victoria E. , Cullen D. Kacy , Wolf John A. 
Published: November 2023

AbstractCognitive impairment is a common symptom following mild traumatic brain injury (mTBI or concussion) and can persist for years in some individuals. Hippocampal slice preparations following closed-head, rotational acceleration injury in swine have previously demonstrated reduced axonal function and hippocampal circuitry disruption. However, electrophysiological changes in hippocampal neurons and their subtypes in a large animal mTBI model have not been examined. Using in vivo electrophysiology techniques, we examined laminar oscillatory field potentials and single unit activity in the hippocampal network 7 days post-injury in anesthetized minipigs. Concussion altered the electrophysiological properties of pyramidal cells and interneurons differently in area CA1. While the firing rate, spike width and amplitude of CA1 interneurons were significantly decreased post-mTBI, these parameters were unchanged in CA1 pyramidal neurons. In addition, CA1 pyramidal neurons in TBI animals were less entrained to hippocampal gamma (40–80 Hz) oscillations. Stimulation of the Schaffer collaterals also revealed hyperexcitability across the CA1 lamina post-mTBI. Computational simulations suggest that reported changes in interneuronal physiology may be due to alterations in voltage-gated sodium channels. These data demonstrate that a single concussion can lead to significant neuronal and circuit level changes in the hippocampus, which may contribute to cognitive dysfunction following mTBI.
Flavinated SDHA underlies the change in intrinsic optical properties of oral cancers
Authors: Marumo Tomoko , Maduka Chima V. , Ural Evran , Apu Ehsanul Hoque , Chung Seock-Jin , Tanabe Koji , van den Berg Nynke S. , Zhou Quan , Martin Brock A. , Miura Tadashi , Rosenthal Eben L. , Shibahara Takahiko , Contag Christopher H. 
Published: November 2023

AbstractThe molecular basis of reduced autofluorescence in oral squamous cell carcinoma (OSCC) cells relative to normal cells has been speculated to be due to lower levels of free flavin adenine dinucleotide (FAD). This speculation, along with differences in the intrinsic optical properties of extracellular collagen, lies at the foundation of the design of currently-used clinical optical detection devices. Here, we report that free FAD levels may not account for differences in autofluorescence of OSCC cells, but that the differences relate to FAD as a co-factor for flavination. Autofluorescence from a 70 kDa flavoprotein, succinate dehydrogenase A (SDHA), was found to be responsible for changes in optical properties within the FAD spectral region, with lower levels of flavinated SDHA in OSCC cells. Since flavinated SDHA is required for functional complexation with succinate dehydrogenase B (SDHB), decreased SDHB levels were observed in human OSCC tissue relative to normal tissues. Accordingly, the metabolism of OSCC cells was found to be significantly altered relative to normal cells, revealing vulnerabilities for both diagnosis and targeted therapy. Optimizing non-invasive tools based on optical and metabolic signatures of cancers will enable more precise and early diagnosis leading to improved outcomes in patients.
Increasing pulse pressure ex vivo, mimicking acute physical exercise, induces smooth muscle cell-mediated de-stiffening of murine aortic segments
Authors: Neutel Cédric H. G. , Weyns Anne-Sophie , Leloup Arthur , De Moudt Sofie , Guns Pieter-Jan , Fransen Paul 
Published: November 2023

AbstractThe mechanisms by which physical activity affects cardiovascular function and physiology are complex and multifactorial. In the present study, cardiac output during rest or acute physical activity was simulated in isolated aortic segments of healthy C57BL/6J wild-type mice. This was performed using the Rodent Oscillatory Tension Set-up to study Arterial Compliance (ROTSAC) by applying cyclic stretch of different amplitude, duration and frequency in well-controlled and manageable experimental conditions. Our data show that vascular smooth muscle cells (VSMCs) of the aorta have the intrinsic ability to “de-stiffen” or “relax” after periods of high cyclic stretch and to “re-stiffen” slowly thereafter upon return to normal distension pressures. Thereby, certain conditions have to be fulfilled: 1) VSMC contraction and repetitive stretching (loading/unloading cycles) are a prerequisite to induce post-exercise de-stiffening; 2) one bout of high cyclic stretch is enough to induce de- and re-stiffening. Aortic de-stiffening was highly dependent on cyclic stretch amplitude and on the manner and timing of contraction with probable involvement of focal adhesion phosphorylation/activation. Results of this study may have implications for the therapeutic potential of regular and acute physical activity and its role in the prevention and/or treatment of cardiovascular disease.
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice
Authors: Liskiewicz Arkadiusz , Khalil Ahmed , Liskiewicz Daniela , Novikoff Aaron , Grandl Gerald , Maity-Kumar Gandhari , Gutgesell Robert M. , Bakhti Mostafa , Bastidas-Ponce Aimée , Czarnecki Oliver , Makris Konstantinos , Lickert Heiko , Feuchtinger Annette , Tost Monica , Coupland Callum , Ständer Lisa , Akindehin Seun , Prakash Sneha , Abrar Faiyaz , Castelino Russell L. , He Yantao , Knerr Patrick J. , Yang Bin , Hogendorf Wouter F. J. , Zhang Shiqi , Hofmann Susanna M. , Finan Brian , DiMarchi Richard D. , Tschöp Matthias H. , Douros Jonathan D. , Müller Timo D. 
Published: November 2023

AbstractThe development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) is considered a breakthrough in the treatment of obesity and type 2 diabetes. But although GIPR–GLP-1R co-agonism decreases body weight with superior efficacy relative to GLP-1R agonism alone in preclinical1–3 and clinical studies4,5, the role of GIP in regulating energy metabolism remains enigmatic. Increasing evidence suggests that long-acting GIPR agonists act in the brain to decrease body weight through the inhibition of food intake3,6–8; however, the mechanisms and neuronal populations through which GIP affects metabolism remain to be identified. Here, we report that long-acting GIPR agonists and GIPR–GLP-1R co-agonists decrease body weight and food intake via inhibitory GABAergic neurons. We show that acyl-GIP decreases body weight and food intake in male diet-induced obese wild-type mice, but not in mice with deletion of Gipr in Vgat(also known as Slc32a1)-expressing GABAergic neurons (Vgat-Gipr knockout). Whereas the GIPR–GLP-1R co-agonist MAR709 leads, in male diet-induced obese wild-type mice, to greater weight loss and further inhibition of food intake relative to a pharmacokinetically matched acyl-GLP-1 control, this superiority over GLP-1 vanishes in Vgat-Gipr knockout mice. Our data demonstrate that long-acting GIPR agonists crucially depend on GIPR signaling in inhibitory GABAergic neurons to decrease body weight and food intake.
Self-supervised deep learning for tracking degradation of perovskite light-emitting diodes with multispectral imaging
Authors: Ji Kangyu , Lin Weizhe , Sun Yuqi , Cui Lin-Song , Shamsi Javad , Chiang Yu-Hsien , Chen Jiawei , Tennyson Elizabeth M. , Dai Linjie , Li Qingbiao , Frohna Kyle , Anaya Miguel , Greenham Neil C. , Stranks Samuel D. 
Published: November 2023

AbstractEmerging functional materials such as halide perovskites are intrinsically unstable, causing long-term instability in optoelectronic devices made from these materials. This leads to difficulty in capturing useful information on device degradation through time-consuming optical characterization in their operating environments. Despite these challenges, understanding the degradation mechanism is crucial for advancing the technology towards commercialization. Here we present a self-supervised machine learning model that utilizes a multi-channel correlation and blind denoising to recover images without high-quality references, enabling fast and low-dose measurements. We perform operando luminescence mapping of various emerging optoelectronic semiconductors, including organic and halide perovskite photovoltaic and light-emitting devices. By tracking the spatially resolved degradation in electroluminescence of mixed-halide perovskite blue-light-emitting diodes, we discovered that lateral ion migration (perpendicular to the external electric field) during device operation triggers the formation of chloride-rich defective regions that emit poorly—a mechanism that would not be resolvable with conventional imaging approaches.
CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice
Authors: Sun Shimin , Meng Yuan , Li Mingying , Tang Xiaolong , Hu Wenjing , Wu Weiwei , Li Guo , Pang Qiuxiang , Wang Wengong , Liu Baohua 
Published: November 2023

AbstractThe stem cell theory of aging dictates that a decline in the number and/or function of stem cells causes tissue degeneration and aging; however, it still lacks unequivocal experimental support. Here, using lineage tracing and single-cell transcriptomics, we identify a population of CD133+ bone marrow-derived endothelial-like cells (ELCs) as potential endothelial progenitor cells, which contribute to tubular structures in vitro and neovascularization in vivo. We demonstrate that supplementation with wild-type and young ELCs respectively restores neovascularization and extends lifespan in progeric and naturally aged mice. Mechanistically, we identify an upregulation of farnesyl diphosphate synthase (FDPS) in aged CD133+ ELCs—a key enzyme in isoprenoid biosynthesis. Overexpression of FDPS compromises the neovascularization capacity of CD133+ ELCs, whereas FDPS inhibition by pamidronate enhances neovascularization, improves health measures and extends lifespan in aged mice. These findings highlight stem cell-based strategies for the treatment of progeria and age-related pathologies.
The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans
Authors: Silva-García Carlos G. , Láscarez-Lagunas Laura I. , Papsdorf Katharina , Heintz Caroline , Prabhakar Aditi , Morrow Christopher S. , Pajuelo Torres Lourdes , Sharma Arpit , Liu Jihe , Colaiácovo Monica P. , Brunet Anne , Mair William B. 
Published: November 2023

AbstractLoss of function during aging is accompanied by transcriptional drift, altering gene expression and contributing to a variety of age-related diseases. CREB-regulated transcriptional coactivators (CRTCs) have emerged as key regulators of gene expression that might be targeted to promote longevity. Here we define the role of the Caenorhabditis elegans CRTC-1 in the epigenetic regulation of longevity. Endogenous CRTC-1 binds chromatin factors, including components of the COMPASS complex, which trimethylates lysine 4 on histone H3 (H3K4me3). CRISPR editing of endogenous CRTC-1 reveals that the CREB-binding domain in neurons is specifically required for H3K4me3-dependent longevity. However, this effect is independent of CREB but instead acts via the transcription factor AP-1. Strikingly, CRTC-1 also mediates global histone acetylation levels, and this acetylation is essential for H3K4me3-dependent longevity. Indeed, overexpression of an acetyltransferase enzyme is sufficient to promote longevity in wild-type worms. CRTCs, therefore, link energetics to longevity by critically fine-tuning histone acetylation and methylation to promote healthy aging.
Traditional and Visual–Acoustic Biofeedback Treatment via Telepractice for Residual Speech Sound Disorders Affecting /ɹ/: Pilot Study
Authors: Ochs Laura C. , Leece Megan C. , Preston Jonathan L. , McAllister Tara , Hitchcock Elaine R. 
Published: November 2023

Purpose:
This study aimed to examine the feasibility of telepractice delivery of a treatment package including visual–acoustic biofeedback (VAB) and motor-based treatment for residual speech sound disorder affecting /ɹ/ in school-age children. The overall study used a single-case randomization design; however, this preliminary report will simply quantify changes in accuracy before and after completion of the treatment package. The present analysis did not differentiate between the relative contributions of biofeedback and motor-based treatments.

Method:
Seven children aged 9–14 years received speech therapy for /ɹ/ distortions via telepractice. The study design consisted of three phases: baseline (four sessions), treatment (20 sessions), and posttreatment (three sessions). Treatment included two sessions weekly for a duration of 10 weeks. The participants received one motor-based/nonbiofeedback session and one VAB session per week. The order of treatment within each week was randomly determined prior to the start of therapy. Overall progress was assessed using untrained listeners' ratings of word probes administered in the baseline and posttreatment phases.

Results:
Findings revealed that six of the seven participants showed a clinically significant response to the overall treatment package, although the magnitude of individual responses varied across speech contexts (consonantal and vocalic) and participants.

Conclusions:
The present results suggest that an intervention combining VAB and motor-based treatment for residual /ɹ/ errors can be effectively delivered via telepractice. Considerations for technology setup and treatment protocols are provided.
A weakly supervised learning pipeline for profiled fibre inspection
Authors: Chen Zhao , Xiu Yahui , Zheng Yuxin , Wang Xinxin , Wang Qian , Guo Danqi , Wan Yan 
Published: November 2023

AbstractAutomatic profiled fibre recognition and analysis can accelerate quality inspection and contributes to the upgrade of the textile industry. However, these tasks often require significant manual effort to generate instance‐level annotations for fully supervised training. In this paper, the authors propose a weakly supervised pipeline for profiled fibre inspection using electron‐microscopic (EM) images with only image‐level annotations. It automatically identifies fibre instances and estimates shape factors to facilitate fibre quality inspection. As the core of the pipeline, the weakly supervised network (WesNet) is designed to localize hundreds of crowded fibre samples by raw patch generation and fibre sample sifting. Particularly, the composite similarity measurement integrates different patch‐wise similarities, enabling the network to distinguish fibre from background robustly. For quality inspection, the pipeline further analyzes the fibre instances, utilizing several efficient techniques to estimate the shape factors. Experiments on the real fibre electron‐microscopic images demonstrate the efficacy and efficiency of the pipeline. Results show that WesNet outperforms several supervised and weakly supervised methods, including two state‐of‐the‐art weakly supervised networks.
Analysis of Atom against quantum attacks
Authors: Anand Ravi , Nandi Rimpa , Isobe Takanori 
Published: November 2023

AbstractA significant amount of study is being done to review the security promises made for the various ciphers now in use as a result of the development of quantum computing technology. A general attack against symmetric key cryptography primitives that can reduce search costs to the square root is Grover's search algorithm. To implement Grover's algorithm, it is necessary that the target cipher be implemented as a quantum circuit. Despite being relatively new, this area of study has received significant attention from the research community. The authors have estimated the cost of Grover's key search attack against the stream cipher Atom, for the first time, under circuit depth restrictions defined in National Institute of Standards and Technology (NIST) PQC standardisation process. The authors implement the quantum circuit of Atom in QISKIT, (open‐source software development kit for working with quantum computers running on IBM Quantum Experience). The results are also compared with other existing literature on LFSR‐based stream ciphers, such as Grain‐v1, Grain‐128‐AEAD, and Lizard. The authors also find that, to the best of their knowledge, in the existing literature on estimating the cost of Grover's attack on symmetric ciphers, Atom is the only 128‐bit key cipher that meets the threshold of ≈2170 set by NIST for quantum security of 128‐bit key ciphers. The authors also analyse the security of Atom against quantum TMDTO attacks.
Speicheldrüsenkarzinome – Monozentrische Erfahrung zu Subtypen und deren Inzidenz über 42 Jahre
Authors: Krauss Christian , Wagner Steffen , Klußmann Jens-Peter , Pons-Kühnemann Jörn , Arens Christoph , Langer Christine , Wittekindt Claus 
Published: November 2023

Zusammenfassung
Hintergrund Speicheldrüsenkarzinome sind selten und heterogen. Über 20 Subtypen sind anerkannt und Risikofaktoren sind vielfältig. Ziel dieser Arbeit war die Bewertung des Subtyps und weiterer Risikofaktoren bei einem monozentrischen Kollektiv aus über vier Jahrzehnten.
Material und Methoden 205 Fälle (Diagnosezeitraum 1972–2014) wurden retrospektiv erhoben und hinsichtlich der Verteilung von Risikofaktoren und deren Einfluss auf die Gesamtüberlebenszeit (overall survival, OS) statistisch ausgewertet.
Ergebnisse 19/24 (79,2%) der in der WHO-Klassifikation gelisteten Subtypen kamen in der Kohorte selten vor (< 5%). Davon wurden 10/24 (41,7%) Subtypen nie diagnostiziert. Das Plattenepithelkarzinom (PEC), Adenokarzinom (AdenoCa), Azinuszellkarzinom (AzinusCa), Mukoepidermoidkarzinom (MEC) und adenoidzystische Karzinom (ACC) sind mit zusammen 145/205 (70,7%) die mit Abstand häufigsten Subtypen. Risikofaktoren sind in diesen Gruppen signifikant unterschiedlich vertreten (z.B. lymphogene Metastasierung und Differenzierungsgrad beim AdenoCa und Alter, T- und UICC-Stadium beim PEC). Das 5-Jahres-Gesamtüberleben aller Patienten war 66,9% und unterscheidet sich signifikant innerhalb der häufigsten Subtypen. Ein unabhängiger Einfluss auf das Gesamtüberleben war in der multivariaten Analyse feststellbar für das Alter der Patienten (p<0,001) sowie das T- (p=0,003) und N-Stadium (p=0,046).
Schlussfolgerungen Die meisten Subtypen traten auch innerhalb von Jahrzehnten ausgesprochen selten oder gar nicht auf. Die häufigsten Diagnosen unterscheiden sich bezüglich der Risikofaktoren als auch hinsichtlich des OS, sodass 3 Risikogruppen gebildet werden können. Schlussfolgernd ist die Betrachtung von TNM alleine für die Prognoseabschätzung beim Speicheldrüsenkarzinom unzureichend.
Comparative Study of Small Vessel (under 0.8 mm) Anastomosed Free Flap and Larger Vessel (over 0.8 mm) Anastomosed Free Flap: Does Supermicrosurgery Provide Sufficient Blood Flow to the Free Flap?
Authors: Kim Hyung Bae , Hong Joon Pio Jp , Suh Hyunsuk Peter 
Published: November 2023

Abstract
Background This study aimed to quantify the blood flow of free flaps and compare the blood flow of small vessel (<0.8 mm) and larger vessel (>0.8 mm) anastomosed free flaps.
Methods This retrospective study included patients treated successfully with a perforator free flap in the lower extremity between June 2015 and March 2017. A color duplex ultrasound system measured the flow volume through the pedicle by analyzing the mean flow peak velocity, flow volume, and flow volume per 100 g of the flap.
Results A total of 69 patients were enrolled in this study. There was no statistical difference in peak velocity between the small vessel anastomosed free flap (25.2 ± 5.6) and larger vessel anastomosed free flap (26.5 ± 5.4). Flow volume (6.8 ± 4.2 vs. 6.3 ± 3.6) and flow volume/100 g (3.6 ± 3.9 vs. 6.2 ± 6.9) also did not show significant differences.
Conclusion Small vessel (<0.8 mm) free flaps showed similar flow velocity and flow volume to larger vessel (>0.8 mm) anastomosed free flaps. Blood flow to the small vessel anastomosed free flap was sufficient despite its small vessel size.