bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orbital lymphosarcoma associated with reticuloendotheliosis virus in a peafowl
Authors: Miller Paul E. , Paul-Murphy Joanne , Sullivan Ruth , Cooley A. James , Dubielzig Richard R. , Murphy Christopher J. , Fadly Aly M. 
Published: December 2023

Lymphosarcoma should be considered in the differential diagnoses of exophthalmia in Indian peafowl.
Complications of orbital exenteration in birds may include profound oculocardiac reflex and hemorrhage. Orbital bleeding may be controlled by direct pressure, electrocautery, topical administration of bovine thrombin, and application of sterile gelatine sponges and oxidized regenerated cellulose. Blood transfusions may be necessary.
Reticuloendotheliosis virus may play a role in the genesis of lymphosarcoma in peafowl.
Management factors affecting the risk for vesicular stomatitis in livestock operations in the western United States
Authors: Hurd H. Scott , McCluskey Brian J. , Mumford Elizabeth L. 
Published: December 2023

Objective
To identify management factors affecting the risk of animals developing vesicular stomatitis (VS).

Design
Case-control study.

Animals
Horses, cattle, and sheep with suspected vesicular stomatitis on 395 premises in Colorado, New Mexico, Utah, and Arizona.

Procedure
Data were collected during the VS outbreak of 1997. Diagnosticians interviewed livestock owners and completed a supplemental questionnaire. Cases were defined as those premises that had a completed questionnaire and had ≥ 1 animal positive for VS. Control premises were all premises investigated that had a completed questionnaire and on which the animals had been tested but VS was not detected.

Results
Animals that had access to a shelter or barn had a reduced risk of developing VS (OR, 0.6; 95% confidence interval [CI], 0.35 to 0.99). This effect was more pronounced for equine premises (OR, 0.5; 95% CI, 0.3 to 0.9). Conversely, during an adjusted analysis on equine premises, risk of developing disease was increased slightly where animals had access to pasture (OR, 2.01; 95% CI, 1.1 to 3.7). On all premises where owners reported insect populations were greater than normal, odds of developing disease were significantly increased (OR, 2.5; 95% CI, 1.47 to 4.47). Premises with animals housed < 0.25 miles from running water were more than twice as likely to have clinical signs of VS (OR, 2.6; 95% CI, 1.32 to 5.0).

Conclusions and Clinical Relevance
These results support reports of others that suggest biting insects are a vector in VS virus transmission. Management practices to reduce exposure to biting insects might reduce the risk of VS. (J Am Vet Med Assoc 1999;215:1263–1268)
Use of infrared thermography to detect inflammation caused by contaminated growth promotant ear implants in cattle
Authors: Spire Mark F. , Drouillard James S. , Galland John C. , Sargeant Jan M. 
Published: December 2023

Objective
To compare the infrared thermographic appearance of bovine ears that had received contaminated growth promotant implants with ears that had received clean implants and ears without implants.

Design
Prospective study.

Animals
32 yearling crossbred beef steers with a mean weight of 322 kg (708 lbs).

Procedure
Contaminated (n = 16) and clean (16) implants were placed in the ears of feedlot cattle. Nonimplanted (n = 32) ears served as a within-animal control for thermographic comparisons. Images of rostral and caudal surfaces were obtained during a 21-day period, using an infrared thermal imaging radiometer. Repeated measures ANOVA was used to determine the relationship between mean temperature in a zone on the rostral surface of the ear and at 3 locations (proximal, middle, distal) on the caudal surface of the ear (response variables) with treatment (ears with contaminated implants or clean implants vs control ears with no implants), time (repeated day of measurement), and interactions among these variables.

Results
Significant temperature differences existed between ears with contaminated implants and control ears. Temperatures for ears with clean implants were significantly higher than control ears on day 2. At low ambient temperatures when the ears became wet, a greater temperature contrast was detected between ears with contaminated implants and control ears.

Conclusions and Clinical Relevance
Thermal imaging of the ears of feedlot cattle is a noninvasive diagnostic tool that can be used to identify cattle with abscesses caused by contaminated growth-promotant implants. (J Am Vet Med Assoc 1999;215:1320–1324)
Levels of Access to Water and their Impacts on The Quality of Life
Authors: Baracho Rafaella Oliveira , Monte Anne Karoline Lima , Da Fonseca Brunna Eduarda Marques , De Oliveira Thaynara Lorrayne , Scalize Paulo Sérgio 
Published: December 2023

Structured abstract: to evaluate the effects of different conditions of accessibility to drinking water in rural population.

Purpose: the way in which water is supplied at home directly influences the health of its inhabitants. In 2017, eight out of ten people living in rural areas did not have access to basic drinking water services or safely managed water services, of which nearly half lived in least developed countries and rural areas.

Method/design/approach: a systematic review was carried out, through metadata analysis, selection of methodologies adopted and the relationships established by the authors between different conditions of access to water and hygiene and health, well-being, water quality, time and cost. The main methodologies adopted are questionnaires and univariate statistical analysis, applied in an associated or not.

Results and conclusion: the closer the rural household is to the water collection point, the better the conditions for developing their productive activities. High indoor plumbing costs, especially for individual catchment solutions, may force some households to use unsafe sources of water supply. It was possible to identify the impacts of the lack of internal plumbing and the difficulty of accessing water in rural communities.

Research implication: understand and highlight the relationship between internal plumbing and its possible effects on humans, especially in rural areas.

Originality/value: it can provide subsidies for public policies on internal plumbing, assisting in the construction of indicators that guide the elaboration and evaluation of these policies.
“Delayed hyperbaric oxygen treatment for cerebral gas embolism can still be life-saving” - a case report
Authors: Hussain Asim , Bothma Pieter , Brodbeck Andreas 
Published: December 2023

Background:
Cerebral gas embolism (CGE) is an uncommon and often preventable iatrogenic complication. Any peri-procedural neurological event should raise suspicion of CGE and treatment should start immediately. Hyperbaric oxygen therapy (HBOT) is the treatment of choice and early referral is essential. However, HBOT has been shown to be beneficial with full recovery even after delays as long as 60 hours. This report is written to increase awareness about the recognition and management of this dreaded complication.

Case Presentation:
We report a case of a patient who suffered a cardiac arrest secondary to CGE during routine coronary angiography followed by a ventriculogram. After successful resuscitation, a review of imaging revealed air in the left ventricle and computed tomography (CT) brain showed parenchymal air locules with surrounding ischemic changes. Neurological examination showed hypertonic reflexes with extensor plantar response and intermittent seizures. Hyperbaric oxygen therapy (HBOT) was arranged but there was a delay of about 14 hours between diagnosis and arrival due to logistical reasons. On arrival, the patient was still having seizures intermittently despite the anti-epileptics and sedative infusions. Seizures stopped within 20 minutes of HBOT initiation and a CT brain done 48 hours later demonstrated mild edema but no residual air. Four more sessions were provided in the following 72 hours. Upon eventual discharge, the patient had a near-full neurological recovery, except for a mild left hemiparesis.

Conclusion:
Acute neurological symptoms after an invasive procedure, should raise the suspicion of CGE. Early HBOT is the treatment of choice as minutes are equal to saved brain cells. However, delayed treatment can still be lifesaving and should be considered.
SYSTEMS BIOLOGY SIGNATURE FOR PROGNOSIS OF NON-OSSIFYING FIBROMA
Authors: Souchelnytskyi Serhiy 
Published: December 2023

Introduction: Non-ossifying fibroma (NOF) is a frequent fibrotic lesion of bone, observed in up to 40% of children. Extensive NOF lesions and deficient healing may cause a pathological fracture or a malignant transformation. Prediction of complications requires knowledge of the mechanisms controlling NOF, and systemic analysis may provide insight into these mechanisms.
Aim: To identify regulators that may predict the risk of complications, e.g., pathologic fracture or malignant transformation.
Methods: Data were retrieved from public databases, e.g., PubMed and dedicated databases. We retrieved regulators with confirmed association with NOF, regulators of processes engaged in NOF, and regulators of bone remodelling and giant cell tumors of bone. Systemic analysis was performed using Cytoscape and FunCoup tools.
Results: Networks representing NOF mechanisms, bone healing, and malignant transformation were generated. The network analysis identified mechanisms that may predict the efficacy of healing of NOF lesion or the risk of malignant transformation of NOF. Forty-one compounds were identified as potential signature predictor of the efficacy of bone healing. The list contains known and novel regulators of bone. Signalling pathways, hormones, vitamins, minerals, proliferation and differentiation regulators are in the 41 signature. We report here a list of 62 molecules that are engaged in bone tumorigenesis and in NOF, e.g., oncogenes and tumor suppressors, tumorigenesis-associated signalling pathways and hormones Deregulation of these molecules increases the risk of malignant transformation of NOF.
Conclusion: The 41 and 62 signatures identify potential markers of the risk of non-efficient healing or malignant transformation of NOF.
THE STUDY OF ASSOCIATIONS BETWEEN IL1Β C3953T GENE POLYMORPHISM AND CLINICAL-NEUROLOGICAL, NEUROIMAGING, HEMODYNAMIC CHARACTERISTICS AND COGNITIVE DYSFUNCTION IN PATIENTS WITH POST-INFECTIOUS ENCEPHALOPATHY
Authors: Duve Khrystyna , Olszewski Robert , Shkrobot Svitlana , Shalabay Natalia 
Published: December 2023

The aim: To investigate potential associations between the C3953T polymorphic variant of the interleukin-one beta (IL1β) gene and clinical-neurological, neuroimaging, hemodynamic characteristics, as well as cognitive dysfunction in patients with post-infectious encephalopathy (PIE).
Materials and methods: A total of 128 patients with post-infectious encephalopathy (PIE) who were receiving inpatient treatment in the neurological departments of the Communal Non-commercial Enterprise “Ternopil Regional Clinical Psychoneurological Hospital” of Ternopil Regional Council,” Ternopil, Ukraine, were examined and included in the retrospective analysis in 2021–2022. The molecular-genetic testing was performed for 26 patients in the molecular genetics laboratory of the State Institution “Reference Centre for Molecular Diagnostics of the Ministry of Health of Ukraine,” Kyiv. The control group consisted of 12 people, who were representative in age and gender. Statistical processing of the results was performed using the STATISTICA 10.0 software.
Results: Analysis of the dependence of neuroimaging changes on the frequency of genotypes of the C3953T polymorphic variant of the IL1β gene in patients with PIE showed a significant relationship between their frequency distribution and the presence/absence of gliosis phenomena (p=0.009). Thus, gliosis was detected in all carriers of the T/T genotype C3953T polymorphic variant of the IL1β gene. Analyzing the dependence of changes obtained during the transcranial Doppler ultrasound scanning of cerebral vessels on the polymorphic variant C3953T of the IL1β gene in patients with PIE, all carriers of the T/T genotype were diagnosed with angiospasm (p=0.038) and vertebrobasilar insufficiency (p=0.010).
Conclusions: Results suggest the reasonability of further researching the interaction between IL1β and glial cells and changes in the cognitive functioning of cytokine genotypes with larger sample sizes that may help explain the pathophysiological mechanisms leading to cognitive impairment in patients with PIE.
THE INFLUENCE OF VESSEL CURVATURE AND THROMBUS COMPOSITION ON THE EFFECTIVENESS AND OUTCOMES OF THROMBECTOMY IN THE CASE OF ACUTE ISCHEMIC STROKE
Authors: Lylyk Pedro , Netliukh Andrii , Kobyletskyi Oleh , Holub Oleksander , Sukhanov Andrian 
Published: December 2023

Introduction. It is believed that vascular anatomy has a direct influence on the complexity and course of mechanical thrombectomy, and its outcome determines the degree of reperfusion and clinical effect.
Aim. To analyze the influence of the curvature of the intracranial arteries and the composition of the thrombus on the results of thrombectomy.
Materials and methods. 64 patients who underwent mechanical thrombectomy for acute proximal occlusion of the ICA or MCA were prospectively examined. (44man/20women among them, the age of the patients ranged from 47-89years (67.2±1.2). The study was performed by measuring the ICA-M1 angle on angiograms in direct projection. Angles were compared between patients with successful (mTICI group 2b/3) and unsuccessful (mTICI group 0-2a) reperfusion. The functional result was evaluated according to the mRS scale as positive (0-3) and negative (4-5). Removed thrombi were examined by light microscopy with hematoxylin-eosin and orange-red-blue staining.
Results. Among patients of the mTICI 2b/3 group, a larger angle of the ICA-M1 was measured (126.4±2.8°) compared to patients in the mTICI 0-2a group - 107.1±4.9° (p=0.05). Among patients with 1-2 passages, statistically significantly larger ICA-M1 angles were recorded (129.8±3.3°) than among patients with a number of passages >2 (109.2±5,7°, p<0.02). The duration of mechanical thrombectomy was <60min among patients with larger angles of the ICA-M1 (127.6±4.4° vs. 119.6±4.5°) than in patients with long interventions (>60 min) (p<0.05). Successful reperfusion (group mTICI 2b/3) was achieved in 47 (73.4%) patients. A clinically positive result(mRS 0-3) was observed among 37(57.8%) patients.
During microscopic examination of thrombi among patient groups mTICI 0/2a, fibrin threads with signs of aging with purple and blue color were present on the periphery (24-48hours). With a favorable outcome of the operation, the coagulated fibrin fibers were stained red (<16hours).
Conclusions. With a smaller curvature of the ICA and its branches, and in the presence of "fresh" thrombi, the efficiency of operations increases, and the number of passages and the duration of mechanical thrombectomy decrease. The neurological status of patients at admission correlates with the functional outcome at the time of discharge.
GUT MICROBIOME IN ACUTE CORONARY SYNDROME
Authors: Yusko Lesya , Chendey Taras , Lohoida Vasyl , Meleshko Tamara , Rishko Mykola , Konic-Ristic Aleksandra , Boyko Nadiya 
Published: December 2023

Introduction: The intestinal microbiome is a diagnostic indicator and therapeutic target for non-communicable diseases. The aim of this work is to test the relationship between arterial stiffness, elasticity, gut microbiota and inflammation markers in the patients with acute coronary syndrome.
Methods: Elastic properties of arteries were evaluated by non-invasive arteriography (Tensiomed, Hungary), and intestinal microbiota was studied with the determination of key representatives by routine culturing methodology using biochemical identification kits (LACHEMA, Czech Republic). The level of SIgA and cytokines were detected by enzyme-linked immunosorbent assay (ELISA). The data obtained for the clinical experimental group of patients were compared with the results obtained for the control group.
Results: Obtained data demonstrated a strong correlation between intestinal colonization by Enterococcus faecalis and PPbr (r=0.98), AIbr (r=-0.99) and AIao (r=-0.99). Significant correlations were found for Escherichia coli (lac+) and PPbr indicators (r=-0.97), and for Klebsiella oxytoca and SBP (r=-0.95), the systolic area index of the volumetric curve (r=+0.99), and the index of the diastolic area of the volumetric curve (r=-0.99). Indexed areas of the volumetric curve were correlated with colonization of Streptococcus spp. (r=-0.9 and 0.9 for systolic and diastolic area, respectively). Blood pressure correlated with the consentration of Candida spp. (r=0.95).
Conclusion: Detected bacteria (E. faecalis, K. oxytoca), pro-inflammatory cytokines, and intestine level of SIgA correlated with increased arterial stiffness and elasticity observed in patients with acute coronary syndromes (ACS) might be used as a rationale for the prevention and individual treatment of ACS in the earlier stages of the disease.
Evaluation of Antioxidant Activity, Total Phenolic Content, and Total Flavonoid Content of the Aerial Part of Canna edulis Ker Gawl.
Authors: Thi Van Anh Nguyen , Thanh Tung Bui , Hong Luyen Le 
Published: December 2023

Canna edulis Ker Gawl. (CE) is an important agricultural plant in Vietnam. The whole plant is traditionally used to treat many different diseases. However, scientific evidence on the pharmacological effects and chemical composition of this plant is limited and focuses mainly on the roots. This study aimed to evaluate the antioxidant activity and quantify the total phenolic and flavonoid content of extracts from the aerial part of CE. The in vitro antioxidant effect was evaluated by DPPH and ABTS free radical scavenging methods. Total phenolic content was evaluated with the Folin-Ciocalteu reagent, and total flavonoid content was evaluated by the aluminum chloride colorimetric method. The results showed that the ethyl acetate fraction had the most antioxidant activity with the IC50 values for DPPH and ABTS of 103.73 ± 9.80 and 76.52 ± 3.57 µg/mL, respectively. In addition, the ethyl acetate fraction contained the highest total phenolic and total flavonoid content with values of 70.93 ± 7.18 mg GAE/g extract and 64.93 ± 5.75 mg QE/g extract, respectively. Therefore, the aerial part of CE, especially the ethyl acetate fraction, is a potential plant source for the investigation of antioxidant compounds.
Keywords: Canna edulis, antioxidant, flavonoids, phenolic, DPPH, ABTS.
Overview of the Research System Cost-effectiveness of Emicizumab in Preventing Bleeding for People with Hemophilia A
Authors: Van Thuy Ha , Thi Thu Thu Tran , Ngoc Nghia Nguyen , Thi Xuan Bui 
Published: December 2023

Systematic review research helps provide more scientific evidence for doctors in drug use as well as policymakers for safe, rational, and effective drug use. Emicizumab was first approved by the FDA in 2017 for patients with congenital hemophilia A and was later approved for prophylaxis. However, the high cost of Emicizumab treatment makes it difficult for patients to access the drug as well as pay for this by the insurance fund. A systematic review of studies on Emicizumab in the world that meets the conditions inclusion and exclusion criteria shows that 7 out of 8 studies (accounting for 87.5%) showed results that helped reduce total costs and increase treatment effectiveness compared to the placebo or alternatives. One study (accounting for 12.5%) resulted in increased total costs and reduced effectiveness compared to the intervention substance. Of these seven studies, one study achieved cost-effectiveness, three studies did not achieve cost-effectiveness (because ICER was lower than the willingness-to-pay threshold), and three studies could not be concluded as to whether they achieved cost-effectiveness.
Keywords: Systematic review, cost, effectiveness, Emicizumab, Hemophilia A.
Modulatory Effects of Ginsenoside Saponins in Panax notoginseng on Steroid Hormones
Authors: Van Khanh Nguyen , Thanh Hai Nguyen , Homma Seijiro , Thi Thu Giang Vu 
Published: December 2023

Natural compounds with structural similarities to endogenous hormones, such as alkaloids, coumestans, flavonoids, lignans, saponins, and stilbenes, have been recognized increasingly for their potential in preventing and treating endocrine disorders related to steroid hormones. Panax notoginseng (Burk.) F. H. Chen, a member of the Araliaceae family and commonly known as Sanqi or Tianqi, is a valuable herbal medicine used to treat various diseases. The majority of saponins (ginsenosides) found in Panax notoginseng belongs to the dammarane triterpenoid group, exhibiting beneficial biological effects, including the treatment of cardiovascular diseases, pain, inflammation, and injuries, as well as internal and external bleeding caused by injury. The aglycone portion of ginsenosides possesses a steroid-like hydrophobic four-ring structure, similar to steroid hormones. Recent studies have indicated that the Panax notoginseng ginsenoside saponins (PNS) have steroid hormone-like activities, bringing the potential for endocrine disorders treatment. Thus, this review aims to provide the chemical structure and steroid hormone-regulating effects of ginsenoside saponins in Panax notoginseng.
Keywords: Panax notoginseng, saponin, steroid hormone, ginsenoside, hormone-like effect.
In vivo Evaluation of Berberine-loaded Liposomes in the Exogenous Hyperlipidemia Animal Model
Authors: Thi Thuan Duong , Thi Quynh Trang Nguyen , Thuy Duong Nguyen , Thanh Hai Nguyen , Thi Minh Hue Pham 
Published: December 2023

Berberine (BBR) is an alkaloid presenting exogenous cholesterol lowering and anti-hyperlipidemia therapeutic effects in the literature. In this study, the exogenous lipid-lowering effects of oral BBR-loaded liposomes were investigated in rats compared with free BBR within four weeks. The BBR-loaded liposomes at the daily oral dose of 25 mg BBR/kg of body weight in rats reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) by 22.34% (p>0.05), 43.93% (p<0.05), respectively. These values (TC and LDL-C) when rats were given BBR-loaded liposomes at the daily oral dose of 50 mg BBR/kg were 30.72% (p<0.05) and 42.77% (p<0.05) compared with those values of the untreated control group, respectively. Both doses of BBR-loaded liposomes have no signals in decreasing triglycerides.
Keywords: Berberine, berberine-loaded liposomes, anti-hyperlipidemia, animal model.