bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in Test-Retest Reliability of Near-Infrared Spectroscopy During Postocclusive Reactive Hyperemia of the Vastus Lateralis
Authors: Shoemaker Marni E. , Smith Cory M. , Gillen Zachary M. , Cramer Joel T. 
Published: October 2023

Abstract
Shoemaker, ME, Smith, CM, Gillen, ZM, and Cramer, JT. Sex differences in test-retest reliability of near-infrared spectroscopy during postocclusive reactive hyperemia of the vastus lateralis. J Strength Cond Res 38(2): e40–e48, 2024—The purpose of this study was to determine test-retest reliability for vascular reactivity measures and ranges for normalization of near-infrared spectroscopy (NIRS) variables from the vastus lateralis using postocclusive reactive hyperemia (PORH) procedure in male subjects, female subjects, and combined. Concentrations of oxygenated hemoglobin (Hb) + myoglobin (Mb) (O2Hb) and deoxygenated Hb + Mb (HHb) to derive total Hb + Mb (THb), difference in Hb + Mb signal (Hbdiff), and muscle tissue oxygen saturation (StO2) from the vastus lateralis were measured during the PORH in 12 male subjects (age: 23.17 ± 1.77 years; stature: 180.88 ± 4.59 cm; and mass: 81.47 ± 9.68 kg) and 10 female subjects (age: 23.80 ± 2.07 years; stature: 165.95 ± 4.92 cm; and mass: 70.93 ± 10.55 kg) on 2 separate days. Adipose tissue thickness at the NIRS site was measured with ultrasonography. There were no significant differences between the mean values from visit 1 to visit 2 (p > 0.076–0.985). In the composite sample, intraclass correlation coefficient (ICC) and coefficient of variation (CV) ranged from 0.35 to 0.91 and 4.74 to 39.18%, respectively. In male subjects, ICC and CV values ranged from 0.57 to 0.89 and 2.44 to 28.55%, respectively. In female subjects, ICC and CV values ranged from −0.05 to 0.75 and 7.83 to 61.19%, respectively. Although NIRS variables were overall reliable during PORH, when separated by sex, reliability in male subjects generally increased, whereas female subjects were not reliable, suggesting adipose tissue thickness may be a contributing factor. Understanding sex differences in reliability is important when using this technique for normalization or examining vascular reactivity during athletic performance. With greater utilization of NIRS monitoring in athletes to examine training adaptations, it is important for practitioners to understand the capabilities and potential limitations of the tool.
Fat-Free Mass Index in a Large Sample of National Collegiate Athletic Association Men and Women Athletes From a Variety of Sports
Authors: Magee Meghan K. , Fields Jennifer B. , Jagim Andrew R. , Jones Margaret T. 
Published: October 2023

Abstract
Magee, MK, Fields, JB, Jagim, AR, and Jones, MT. Fat-free mass index in a large sample of National Collegiate Athletic Association men and women athletes from a variety of sports. J Strength Cond Res 38(2): 311–317, 2024—Fat-free mass index (FFMI) can be used to categorize fat-free mass (FFM) relative to height. Normative values have been established in a variety of sports, as has suggested lower and upper thresholds of FFMI. However, FFMI has not been reported in a large sample of athletes, representing both sexes and multiple sport types. The purpose of this study was to evaluate differences in FFMI and establish normative values across a large sample of collegiate sports. A total of 1,961 athletes (men: n = 596, 10 sports; women: n = 1,365, 8 sports) participated. Height and mass were measured using a stadiometer and calibrated digital scale, respectively. Fat-free mass was assessed with air displacement plethysmography and used to calculate FFMI. Kruskal-Wallis test and one-way analysis of variance evaluated differences in FFMI in women's and men's sports, respectively. When collapsed across sport type and stratified by sex, men had a higher FFMI (21.5 ± 1.9 kg·m−2 vs. 17.9 ± 1.8 kg·m−2; p < 0.001). Differences occurred in FFMI across sport. In women, basketball athletes had the highest FFMI (18.9 kg·m−2) and highest 99th percentile for FFMI, whereas rowers had the lowest (16.9 kg·m−2). In men, throwers had the highest FFMI (25.7 kg·m−2) and highest 99th percentile, whereas volleyball athletes had the lowest (19.9 kg·m−2). Differences in FFMI may be attributable to dietary habits and physiological demands of respective sports. These results can provide information relative to differences in FFMI values across sports. In addition, sport-specific normative values can be used as benchmarks and targets for training, nutrition, and goal setting.
Influence of Maturation and Determinants of Repeated-Sprint Ability in Youth Basketball Players
Authors: Gonzalo-Skok Oliver , Bishop Chris 
Published: October 2023

Abstract
Gonzalo-Skok, O, and Bishop, C. Influence of maturation and determinants of repeated-sprint ability in youth basketball players. J Strength Cond Res 38(2): 325–333, 2024—The main aims of the current study were (a) to determine the main predictors of general and specific repeated-sprint ability (RSA) tests, (b) to analyze the relationships between RSA tests and independent measures of physical performance, (c) to examine whether between-age differences exist, and (d) to assess whether maturation affects those mentioned above in young basketball players. Thirty-five young (U-14 to U-16), highly trained basketball players performed a linear sprint test (5, 10, and 25 m), an incremental running test, and 2 repeated-sprint tests (general [RSG]: 6 × 25 m; specific [RSS]: 6 × 5 + 5 m with a 45° change of direction and 20 seconds of passive recovery in both tests). Anthropometric variables were measured and used to calculate age at peak height velocity (APHV), which was used to determine maturation. The main determinants of RSA tests were aerobic performance and linear sprinting for RSS (R
2 = 0.84) and adding the percentage of body fat for RSG (R
2 = 0.94). Almost perfect relationships (r = 0.93–0.99) were found between all RSA variables (i.e., the best [RSGb and RSSb] and mean time [RSGm and RSSm]). As age increased, performance in RSA was evident, as shown by improved best and mean scores. When APHV was controlled for, no significant differences were apparent in the comparison from U-14 and U-16 in 25 m, RSGb, and RSGm. By contrast, significant differences (p < 0.05) were still evident with APHV controlled between U-14 and U-16 in 5 m, 10 m, RSSb, and RSSm. In conclusion, maturation positively affects linear sprinting and linear RSA performance, whereas specific (multidirectional) RSA seems to be related to other factors.
miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network
Authors: Pulcrano Salvatore , De Gregorio Roberto , De Sanctis Claudia , Volpicelli Floriana , Piscitelli Rosa Maria , Speranza Luisa , Perrone-Capano Carla , di Porzio Umberto , Caiazzo Massimiliano , Martini Alessandro , Giacomet Cecilia , Medina Diego , Awatramani Rajeshwar , Viggiano Davide , Federici Mauro , Mercuri Nicola B. , Guatteo Ezia , Bellenchi Gian Carlo 
Published: October 2023

In the brain, microRNAs (miRNAs) are believed to play a role in orchestrating synaptic plasticity at a higher level by acting as an additional mechanism of translational regulation, alongside the mRNA/polysome system. Despite extensive research, our understanding of the specific contribution of individual miRNA to the function of dopaminergic neurons (DAn) remains limited. By performing a dopaminergic-specific miRNA screening, we have identified miR-218 as a critical regulator of DAn activity in male and female mice. We have found that miR-218 is specifically expressed in mesencephalic DAn and is able to promote dopaminergic differentiation of embryonic stem cells and functional maturation of transdifferentiated induced DA neurons. Midbrain-specific deletion of both genes encoding for miR-218 (referred to as miR-218-1 and mir218-2) affects the expression of a cluster of synaptic-related mRNAs and alters the intrinsic excitability of DAn, as it increases instantaneous frequencies of evoked action potentials, reduces rheobase current, affects the ionic current underlying the action potential after hyperpolarization phase, and reduces dopamine efflux in response to a single electrical stimulus. Our findings provide a comprehensive understanding of the involvement of miR-218 in the dopaminergic system and highlight its role as a modulator of dopaminergic transmission.SIGNIFICANCE STATEMENTIn the past decade, several miRNAs have emerged as potential regulators of synapse activity through the modulation of specific gene expression. Among these, we have identified a dopaminergic-specific miRNA, miR-218, which is able to promote dopaminergic differentiation and regulates the translation of an entire cluster of synapse related mRNAs. Deletion of miR-218 has notable effects on dopamine release and alters the intrinsic excitability of dopaminergic neurons, indicating a direct control of dopaminergic activity by miR-218.
Hypersensitivity to Distractors in Fragile X Syndrome from Loss of Modulation of Cortical VIP Interneurons
Authors: Rahmatullah Noorhan , Schmitt Lauren M. , De Stefano Lisa , Post Sam , Robledo Jessica , Chaudhari Gunvant , Pedapati Ernest , Erickson Craig , Portera-Cailliau Carlos , Goel Anubhuti 
Published: October 2023

Attention deficit is one of the most prominent and disabling symptoms in Fragile X syndrome (FXS). Hypersensitivity to sensory stimuli contributes to attention difficulties by overwhelming and/or distracting affected individuals, which disrupts activities of daily living at home and learning at school. We find that auditory or visual distractors selectively impair visual discrimination performance in humans and mice with FXS but not in typically developing controls. In both species, males and females were examined. Vasoactive intestinal polypeptide (VIP) neurons were significantly modulated by incorrect responses in the poststimulus period during early distractor trials in WT mice, consistent with their known role as error signals. Strikingly, however, VIP cells fromFmr1−/−mice showed little modulation in error trials, and this correlated with their poor performance on the distractor task. Thus, VIP interneurons and their reduced modulatory influence on pyramidal cells could be a potential therapeutic target for attentional difficulties in FXS.SIGNIFICANCE STATEMENTSensory hypersensitivity, impulsivity, and persistent inattention are among the most consistent clinical features of FXS, all of which impede daily functioning and create barriers to learning. However, the neural mechanisms underlying sensory over-reactivity remain elusive. To overcome a significant challenge in translational FXS research we demonstrate a compelling alignment of sensory over-reactivity in both humans with FXS andFmr1−/−mice (the principal animal model of FXS) using a novel analogous distractor task. Two-photon microscopy in mice revealed that lack of modulation by VIP cells contributes to susceptibility to distractors. Implementing research efforts we describe here can help identify dysfunctional neural mechanisms associated not only with sensory issues but broader impairments, including those in learning and cognition.
Critical-like Brain Dynamics in a Continuum from Second- to First-Order Phase Transition
Authors: Wang Sheng H. , Siebenhühner Felix , Arnulfo Gabriele , Myrov Vladislav , Nobili Lino , Breakspear Michael , Palva Satu , Palva J. Matias 
Published: October 2023

The classic brain criticality hypothesis postulates that the brain benefits from operating near a continuous second-order phase transition. Slow feedback regulation of neuronal activity could, however, lead to a discontinuous first-order transition and thereby bistable activity. Observations of bistability in awake brain activity have nonetheless remained scarce and its functional significance unclear. Moreover, there is no empirical evidence to support the hypothesis that the human brain could flexibly operate near either a first- or second-order phase transition despite such a continuum being common in models. Here, using computational modeling, we found bistable synchronization dynamics to emerge through elevated positive feedback and occur exclusively in a regimen of critical-like dynamics. We then assessed bistabilityin vivowith resting-state MEG in healthy adults (7 females, 11 males) and stereo-electroencephalography in epilepsy patients (28 females, 36 males). This analysis revealed that a large fraction of the neocortices exhibited varying degrees of bistability in neuronal oscillations from 3 to 200 Hz. In line with our modeling results, the neuronal bistability was positively correlated with classic assessment of brain criticality across narrow-band frequencies. Excessive bistability was predictive of epileptic pathophysiology in the patients, whereas moderate bistability was positively correlated with task performance in the healthy subjects. These empirical findings thus reveal the human brain as a one-of-a-kind complex system that exhibits critical-like dynamics in a continuum between continuous and discontinuous phase transitions.SIGNIFICANCE STATEMENTIn the model, while synchrony per se was controlled by connectivity, increasing positive local feedback led to gradually emerging bistable synchrony with scale-free dynamics, suggesting a continuum between second- and first-order phase transitions in synchrony dynamics inside a critical-like regimen. In resting-state MEG and SEEG, bistability of ongoing neuronal oscillations was pervasive across brain areas and frequency bands and was observed only with concurring critical-like dynamics as the modeling predicted. As evidence for functional relevance, moderate bistability was positively correlated with executive functioning in the healthy subjects, and excessive bistability was associated with epileptic pathophysiology. These findings show that critical-like neuronal dynamicsin vivoinvolves both continuous and discontinuous phase transitions in a frequency-, neuroanatomy-, and state-dependent manner.
ROS-based nanomedicines for anti-inflammatory therapies
Authors: Repellin Mathieu , Guerin Hanäé , Catania Giuseppina , Lollo Giovanna 
Published: October 2023

Graphical abstract

Abstract
Reactive oxygen species (ROS) are important signaling molecules that play key roles in the progression of inflammatory disorders. Owing to a mismatch of the antioxidant level to balance the overproduction of ROS, the induced chronic inflammation can lead to several type of diseases such as cancer, inflammatory bowel disease, atherosclerosis, diabetes or neurodegenerative disorders. Over the last years, nanomedicine has shown tremendous promise in ROS-regulating approaches. The development of advanced redox-active nanomaterials opened the range of possibilities to anti-inflammatory therapies, with the production of ROS-responsive nanosystems enabling targeted drug delivery or with the manufacture of ROS-scavenging nanomaterials reducing ROS excess levels. This review summarizes the latest developments and novel designs of ROS-based nanomedicines and discusses their therapeutical strategies and applications.
Kliping Digital Perpustakaan: Inovasi Layanan Informasi Cepat Saji dan Mutakhir
Authors: Hariyah Hariyah , Budiawan Luki 
Published: October 2023

Tulisan ini menjelaskan mengenai kliping digital perpustakaan yang dapat menjadi salah satu media dalam mememenuhi kebutuhan informasi pengguna perpustakaan. Sebuah format baru kliping media masa yang menggunakan kemampuan teknologi informasi dan komunikasi agar diseminasi dan pemanfaatannya menjadi lebih cepat dan luas. Metode yang digunakan adalah penelitian kualitatif dengan pendekatan metode deskriptif. Penelitian memaparkan alur dan teknis pembuatan kliping digital mulai dari menentukan tema, menata, mengedit hingga siap disebarkan melalui jejaring media sosial perpustakaan. Kliping digital mejadi salah satu layanan perpustakaan yang berisi informasi cepat saji dan mutakhir serta mampu menjangkau pemustaka secara lebih luas.
Comparative evaluation of non enzymatic antioxidants, vitamin C and albumin in patients suffering from different grades of periodontitis: a retrospective observational study
Authors: Narendra Suryakanta , Rath Gayatri , Mohanty Debasis , Jena Sanghamitra 
Published: October 2023

Background: Rate of degree of destruction of periodontium may be associated with the oxidative stress due to the imbalance of different serum antioxidants. The objective of this study is to compare the evaluated concentrations of non enzymatic antioxidants like vit-C, albumin levels and total antioxidant status, from the available data of patients with slowly and rapidly progressive periodontitis (RPP).
Methods: This retrospective observational study was confined to a study population, which include; 42 patients with RPP, 42 patients with slowly progressive periodontitis (SPP) and 86 healthy controls, in whom the required data were available. The levels of non enzymatic antioxidants like albumin, vitamin C and total antioxidant capacity (TAC) of patients, suffering from RPP, are compared with SPP and healthy controls.
Results: The values of serum albumin and vitamin-c levels in RPP even remaining within the normal ranges were found to be on the lower side, when compared with healthy controls. The systemic TAC levels were found to be at a lower side in both SPP and RPP, when compared with the healthy control group.
Conclusions: The systemic levels of non enzymatic antioxidants, vit C and albumin, in RPP were found to be on the lower side, even remaining within the normal ranges, when compared with the healthy controls. The TAC in SPP and RPP is also found to be on lower side, consistent with previous studies.
Analyzing the Ability of Various Chosen Medicinal Herbs to Cure Wounds in African Catfish (Clarias gariepinus, Burchell 1822)
Authors: Tiamiyu Adebisi Musefiu , Bolaji-Alabi Follusho B , Okocha Reuben C , Olatoye Isaac O , Adedeji Oluwafemi Bolarinwa 
Published: October 2023

Phytomedicines are affordable, safe, and offer great potential for treating and controlling wounds. The effects of herbal supplements on Clarias gariepinus wound healing was investigated. Twenty-four fish (146.4±0.74g) randomised into four paired sub-groups: G1 and G2, G3 and G4, G5 and G6, G7, and G8 were fed formulated rations containing no herbal additive (0.0g/kg), 5.0g/kg of Allium sativum, 10.0g/kg of Chromolaena odorata and 10.0g/kg of Talinum triangulare as feed additive respectively at 5% body weight. On the 21st day, a sterile incision measuring 45.0 mm by 1.0 mm was made on the dorsolateral side of each fish. Subgroups G2, G4, G6, and G8 were intraperitoneally inoculated with 0.1 ml of pathogenic Pseudomonas aeruginosa that had been predetermined (1.4 x106 bacteria/ml), while G1, G3, G5, and G7 were not inoculated. Post-incision, macroscopic parameters (measurements), given as percentage healing rates on days 3, 6, 9, 12, and 15, were used to evaluate the wound closure. Data were analyzed using descriptive statistics and ANOVA at α0.05. On day 3, there were significant differences between the control and treatment groups in the healing pattern (P < 0.05). On day 15 post-incision, G7 had the best healing rate in both inoculated (86.7 percent) and uninoculated (100 percent) fish, while G1 had the lowest healing rate (0.0 percent) and maximum healing rate (64.4 percent), respectively. The findings indicated that Talinum triangulare at a concentration of 10.0 g/kg was the optimum feed additive for promoting wound healing in Clarias gariepinus.
Intelligent Prediction of Drilling Rate of Penetration Based on Method-Data Dual Validity Analysis
Authors: Wan Youwei , Liu Xiangjun , Xiong Jian , Liang Lixi , Ding Yi , Hou Lianlang 
Published: October 2023

Summary
The rate of penetration (ROP) is a critical parameter in drilling operations, essential for optimizing the drilling process and enhancing drilling speed and efficiency. Traditional and statistical models are inadequate for predicting ROP in complex formations, as they fail to conduct a comprehensive analysis of method validity and data validity. In this study, geological conditions parameters, mechanical parameters, and drilling fluid parameters were extracted as prediction parameters, and an intelligent ROP prediction method was constructed under method-data dual validity analysis. The effectiveness of the ROP prediction method is studied by comparing five machine learning algorithms. The data validity of ROP prediction is also studied by changing the input data type, input data dimension, and input data sampling method. The results show that the effectiveness of the long short-term memory (LSTM) neural network method was found to be superior to support vector regression (SVR), backpropagation (BP) neural network, deep belief neural network (DBN), and convolutional neural network (CNN) methods. For data validity, the best input data type for ROP prediction is geological conditions parameters after principal component analysis (PCA) combined with mechanical parameters and drilling fluid parameters. The lower limit of input data dimension validity is seven input parameters, and the accuracy of prediction results increases with the increase of data dimension. The optimal data sampling method is one point per meter, and the error of the prediction result increases and then decreases with the increase of sampling points. Through step-by-step analysis of method validity, input data type, input data dimension, and input data sampling method, the range, size, and mean of error values of ROP prediction results were significantly reduced, and the mean absolute percentage error (MAPE) of the prediction results of the test set is only 18.40%, while the MAPE of the prediction results of the case study is only 11.60%. The results of this study can help to accurately predict ROP, achieve drilling speedup in complex formations, and promote the efficient development of hydrocarbons in the study area.
Accurate Identification of Micro-scale Urban Functional Zones from the Perspective of Spatial Dialectic
Authors: Zhang Changfan 
Published: October 2023

Abstract
With the advancement of global urbanization, accurate identification of urban functional zones has become a crucial task for the high-quality development of cities. Traditional methods that rely on POI data are insufficient to accurately identify micro-scale urban functional zones. Thus, this study proposes a novel method for identifying urban functional zones based on VOI (Volume of Interest) data and applies it to a small region in Hong Kong for comparative research. Subsequently, the identification accuracy of the two methods is assessed using a confusion matrix and the Kappa Coefficient. The results show that the VOI data contains richer and more comprehensive urban spatial information compared to POI data, enabling a superior representation of connections and influences among different zones within cities. The study can be applied to analyse micro-scale urban functional zones in other cities, providing a new perspective for the in-depth research.