bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFECTO DE LA POSICIÓN DEL ÁCIDO ASPÁRTICO EN LA SOLUBILIDAD Y EN LA ADSORCIÓN SOBRE HIDRÓXIDO DE ALUMINIO DE UNA SERIE DE PÉPTIDOS ANÁLOGOS
Authors: Trujillo Mary , Oviedo Luis A. , Guzmán Fanny , Calvo Julio C. 
Published: October 2023

Con el fin de analizar el fenómeno de la adsorción física de un péptido sobre hidróxido de aluminio, se sintetizaron dos series de análogos de una secuencia de 20 aminoácidos proveniente del fragmento de 42 kD de la proteína MSP-1 de Plasmodium falciparum, sustituyendo cada una de las posiciones por ácido aspártico o por lisina. Los resultados de estas modificaciones no mostraron una tendencia regular en la solubilidad o en la adsorción de los análogos. En la serie de ácido aspártico, el péptido de mayor adsorción es el correspondiente a la sustitución de la posición 6 y el de menor a la posición 5; sin embargo, no se observaron diferencias estructurales significativas entre estos dos análogos. La disminución de la adsorción de los análogos de la serie de lisina respecto a la secuencia original, indica que este fenómeno es dirigido principalmente por efectos electrostáticos.
Design of Experiment Guided Establishment of a Fermentative Bioprocess for Biomass-Bound Astaxanthin with <em>Corynebacterium glutamicum</em>
Authors: Meyer Florian , Schmitt Ina , Schäffer Thomas , Wendisch Volker F. , Henke Nadja A. 
Published: October 2023

Corynebacterium glutamicum is prominent for the industrial production of secreted amino acids. Notably, it naturally accumulates the carotenoid pigment decaprenoxanthin in its membranes. Metabolic engineering enabled production of astaxanthin. Here, a bioprocess for astaxanthin production in lab-scale stirred bioreactors was established by a DoE-guided approach to optimize the basic process parameters pH, rDOS, aeration rate as well as inoculation cell density. The DoE-guided approach from 2 L scale cultivation revealed that the pH showed the strongest effect on the product formation. Subsequently, an optimum at pH 8, an aeration rate of 0.25 vvm, 30 % rDOS and an initial optical density of 1 was established that allowed production of 7.6±0.6mg L-1 astaxanthin in batch mode. These process conditions were successfully transferred to a fed-batch process resulting in a high cell density cultivation with up to 60 g CDW L-1 biomass and 64 mg L-1 astaxanthin and thus demonstrating an about 9-fold improvement compared to optimal batch conditions. Moreover, pH shifts experiments indicate that the cells can quickly adapt to a change from pH 6 to 8 and start producing astaxanthin showing the possibility of a biphasic bioprocesses for astaxanthin production.
It’s a trap!: Modern and ancient halite as Lagerstätten
Authors: Gibson Martha E. , Benison Kathleen C. 
Published: October 2023

ABSTRACTChemical sediments, such as bedded halite (NaCl), are strongly influenced by environmental conditions during deposition and, if unaltered, may preserve microorganisms, microfossils, and organic compounds for hundreds of millions of years. Recent studies show that halite is an excellent repository for organic materials, as well as a variety of environmental data. Halite is a perfect trap. Due to its rapid growth, parent brine, gas, crystals of other minerals, and any organic material are encased within primary fluid inclusions or as solid inclusions along growth bands. These inclusions function as “snapshot” repositories of the hydrosphere, atmosphere, lithosphere, and biosphere. However, organic material in halite is still relatively unknown in the sedimentological and paleontological communities. Here, we present highlights of preservation in halite to showcase the diversity of life that has been documented within it. We also discuss: 1) the properties of halite that give it such excellent preservation potential, 2) the challenges to and strategies for studying organic material in halite, 3) preservation in other salt minerals such as gypsum, and 4) implications for astrobiological research. Recommendations for the future study of organic material in halite include collaboration amongst chemical sedimentologists, paleontologists, and microbiologists.
Mechanism Analysis and Mathematical Modeling of Brittle Failure in Rock Cutting with a Single Sharp Cylinder-Shaped PDC Cutter
Authors: Wei Jiusen , Liu Wei , Gao Deli 
Published: October 2023

Summary
The drilling efficiency of a polycrystalline diamond compact (PDC) bit plays a vital role in oil and gas exploration, which is greatly affected by the rock-cutting performance of a single PDC cutter. Although many research efforts have been put in, the rock-cutting mechanism of a single PDC cutter is still indistinct. In this work, the rock-cutting process of a single sharp cylinder-shaped PDC cutter was captured using a high-speed camera. The brittle failure mode mechanism in the rock cutting of the PDC cutter was thus revealed by this real-time observation combined with the findings in previous publications. The brittle rock-cutting failure zones in front of the cutter were separated into three different zones: crushing zone, plastic flow zone, and rock chipping zone. The crushing zone grew while the cutter cut forward and generated a plastic flow zone. When the crushing zone was large enough, a tensile crack would tear apart the rock, forming the rock chip. Based on this rock-cutting mechanism, a new mathematical model of brittle failure in rock cutting of PDC cutter was developed, considering the rock properties and cutting parameters. The boundary geometry of the crushing zone was calculated using elastoplastic theory and the Mohr-Coulomb criterion. All forces on the boundaries of these three failure zones were calculated and combined into the tangential and normal forces in the 3D mathematical model. Furthermore, a new parameter, named as crescent area, was proposed in the mathematical model. When compared to previous publications, the newly developed mathematical model had no variables that needed to be calibrated with experimental data fitting. Moreover, a series of single PDC cutter cutting tests were carried out at various depths of cut (DOCs) and backrake angles to validate the mathematical model. The results showed that the model-predicted forces basically matched the experimental data. The modeling and experimental results shared the same trend for both tangential and normal cutting forces. The experimental phenomena could be well explained by the developed mathematical model. For example, the cutting forces increase with increasing DOC and backrake angle, which is caused by the changing of the crescent area of the rock-cutter interaction. All resultant forces have almost the same inclination angle to the horizontal plane because of the almost constant boundary shape of the crushing zone. The differences between modeling and experimental results could be attributed to several reasons, one of which was the oversimplified plastic flow zone. This work presents a mathematical model that can guide the PDC bit design at different formation properties.
Constructing an artificial leaf with highly reactive microinterface for solar-driven flow-through water purification
Authors: Zhang Jun , Qu Songying , Lin Lin , Li Xiaoyan 
Published: October 2023

Abstract
Advanced oxidation processes that rely on reactive oxygen species represent effective approaches towards water purification, but they are often energy- and chemical- intensive. Here, we show a solar cell with highly reactive microinterface for high-flux wastewater treatment with requirements for only water, oxygen and sunlight. Experiments demonstrate that the hydrogen peroxide is produced in the porous cathode via photoelectrons mediated two-electron oxygen reduction and then flows to the porous photoanode surface, which is instantly activated to hydroxyl radicals (•OH) by light and integrated with the indigenous •OH generated via holes mediated one-electron water oxidation. Accordingly, a microscale region (~ 150 µm for thickness) with high-density •OH (~ 2.5 mM) is successfully constructed, spatially constrained on the photoanode surface. The refractory pollutants (such as norfloxacin) in water pass through this microinterface successively and are degraded rapidly (> 99% in ~ 0.6 s retention time) due to the violent collision between •OH and targets, even after 360 hours of long-term operation. Our findings highlight an innovative catalytic platform design scheme for efficient water purification.
Advancing Tau-PET quantification in Alzheimer's disease with machine learning: introducing THETA, a novel tau summary measure
Authors: Gebre Robel , Moscoso Alexis , Raghavan Sheela , Wiste Heather , Sparrman Kohl , Heeman Fiona , Costoya-Sánchez Alejandro , Schwarz Christopher , Spychalla Anthony , Lowe Val , Graff-Radford Jonathan , Knopman David , Petersen Ronald , Schöll Michael , Jack Clifford , Vemuri Prashanthi 
Published: October 2023

Abstract
Alzheimer's disease (AD) exhibits spatially heterogeneous 3R/4R tau pathology distributions across participants, making it a challenge to quantify extent of tau deposition. Utilizing Tau-PET from three independent cohorts, we trained and validated a machine learning model to identify visually positive Tau-PET scans from regional SUVR values and developed a novel summary measure, THETA, that accounts for heterogeneity in tau deposition. The model for identification of tau positivity achieved a balanced test accuracy of 95% and accuracy of ≥87% on the validation datasets. THETA captured heterogeneity of tau deposition, had better association with clinical measures, and corresponded better with visual assessments in comparison with the temporal meta-region-of-interest Tau-PET quantification methods. Our novel approach aids in identification of positive Tau-PET scans and provides a quantitative summary measure, THETA, that effectively captures the heterogeneous tau deposition seen in AD. The application of THETA for quantifying Tau-PET in AD exhibits great potential.
How Men and Women Use Smartphones for Social Networking: A case study of Bangladesh
Authors: Shabur Md. Abdus 
Published: October 2023

Abstract
This research looked on the gender gap in smartphone app usage and the impact of gender on smartphone-based social networks and social support in Bangladesh, a south Asian country. The sample of smartphone-owning 250 college/university students was surveyed online. Results showed that women were more likely to utilize a smartphone's camera than men were, but men were more inclined to make phone calls and use apps developed expressly for smartphones. Moreover, the findings revealed unique behaviors associated with the use of smartphones in the upkeep of interpersonal connections. Women were more likely to think bonding ties enhanced while using smartphones for text communications, whereas men were more inclined to believe more bridge links expanded. According to these findings, women tend to be more likely to use their cellphones to improve already-strong connections, whilst men appear to be more prone to use them to boost already-weak social relationships.
Catalytic thiolation-depolymerization of oxyphenylene type super engineering plastics via selective carbon-oxygen main chain cleavages
Authors: Minami Yasunori , Imamura Sae , Matsuyama Nao , Nakajima Yumiko , Yoshida Masaru 
Published: October 2023

Abstract
As the effective use of carbon resources has become a pressing societal issue, the importance of chemical recycling of plastics has increased. The catalytic depolymerization method for plastics is a promising approach for creating valuable products under efficient and mild conditions. Although depolymerization methods for various commodity plastics and several engineering plastics have been developed, the degradation of robust super engineering plastics that have very high heat resistance, chemical resistance, and low solubility is nearly unexplored. Herein, we report the catalytic depolymerization of oxyphenylene-based super engineering plastics such as polyetheretherketone, polysulfone, and polyetherimide using thiols via selective carbon–oxygen main chain cleavage to form monomer-type molecules, electron-deficient arenes with sulfur functional groups and bisphenols. The catalyst combination of a bulky phosphazene base P4-tBu with inorganic bases such as tripotassium phosphate or cesium carbonate enabled smooth depolymerization by activating the thiols to form reactive thiolates. This depolymerization method could be utilized with carbon- or glass fiber-enforced polyetheretherketone materials and a consumer resin. The sulfur functional groups in one product could be transformed to amino and sulfonium groups and fluorine by using suitable catalysts. Notably these fluorinated products are the monomers of the parent super engineering plastics.
Domestic, family and sexual violence polyvictimisation and health experiences of Australian nurses, midwives and carers: A cross-sectional study.
Authors: McLindon Elizabeth Veronica-Mary , Spiteri-Staines Anneliese , Hegarty Kelsey 
Published: October 2023

Abstract

Background
Domestic, family and sexual violence is a prevalent health and social issue. Nurses may be exposed to higher rates of this violence in their personal lives compared to the community, but little is known about their polyvictimisation experiences or health and well-being impacts.
Methods
An online descriptive, cross-sectional survey of 10,674 women nurses, midwives and carer members of the Australian Nursing and Midwifery Federation (ANMF) (Victorian Branch) (response rate: 15.2% of nurses sent an invitation email/28.4% opened the email). Violence survey measures included: intimate partner violence (Composite Abuse Scale); child abuse and sexual violence (Australian Bureau of Statistics Personal Safety Survey items). Health measures included: Short Form-12; Fast Alcohol Screening Test; Patient Health Questionnaire-4; Short Screening for DSM-IV Posttraumatic Stress Disorder; well-being measures included: Connor-Davidson Resilience Scale, social support, and financial stress. Proportions were used to describe the prevalence of violence by sociodemographic characteristics and health and well-being issues; logistic regression predicted the odds of experiencing overlapping types of violence and of experiencing health and well-being outcomes.
Results
5,982 participants had experienced at least one type of lifetime violence; half (50.1%) had experienced two or three types (polyvictimisation). Survivors of child abuse were three times more likely to experience both intimate partner violence and non-partner adult sexual assault. Any violence was associated with poorer health and well-being, and the proportion of affected participants increased as the types of violence they experienced increased. Violence in the last 12-months was associated with the poorest health and well-being.
Conclusions
Findings suggest a cumulative, temporal and injurious life course effect of domestic, family and sexual violence. The polyvictimisation experiences and health and well-being associations reported by survivor nurses underscore the need for more accessible and effective workplace interventions to prevent and mitigate psychological ill health, especially in the recent aftermath of violence.
Development of an Instrument to Measure the Competencies of Respectful Maternity Care: A methodological study
Authors: Bester Lizelle , Dyk Lizemari Hugo-Van 
Published: October 2023

Abstract

Background:Despite respectful maternity care (RMC) being an essential component of safe and quality maternity care, disrespectful maternity care still occurs globally. A theory-practice gap is evident between student education in RMC and what is being role modelled by skilled birth attendants within the clinical learning environment. Therefore, the competency of skilled birth attendants in RMC needs to be advanced to strengthen it in practice. Strengthening the RMC practices of skilled birth attendants may also contribute to the ways in which students transfer their learning, by creating a positive work and learning environment. As a result, motivated students might model competent RMC behavior, thus contributing to future skilled birth attendants’ transfer of learning of RMC practices. An instrument that measures competency in RMC practices can aid in determining whether skilled birth attendants and/or students are competent in rendering this kind of care. An RMC tool can also assist in identifying professional developmental areas. However, as no such instrument exists yet – one that measures the knowledge, skills, and behavior of skilled birth attendants in RMC practices – the need for the development of such an instrument was identified was this research.Methods:A methodological research design was implemented to develop the instrument; a literature search was conducted using the string search to identify elements related to the knowledge, skills, and behavior of skill birth attendants performing sound RMC to formulate measurable RMC items. Forty-four items were included in the developed instrument, and a Delphi technique determined face and content validity. Data for the Delphi study were gathered from experts using an online questionnaire via the Evasys® platform, and a consensus was reached after two Delphi rounds.Results:Experts agreed that all 44 items pertaining to the skilled birth attendants’ ' knowledge, skills, and behavior in RMC should be included in theRMC competency measuring instrument.No new items emerged from the Delphi rounds.Conclusion:The development and validation of thisRMC competency measuring instrumentcan measure competence in RMC, which could contribute to the training of students and skilled birth attendants and to countering the trend of disrespectful maternity care.
Quality Improvement in Medicines Regulation: A Retrospective Analysis of the Pharmacy Board of Sierra Leone pre and post-ISO 9001:2015 Certification era
Authors: Lahai Michael , Lake Laurie , Vandy Ahmed , Sebba Bondu , Sesay Mohamed , Abiri Onome T. , Johnson Joy , Buffa Tamba , Kanu Abdulai , Bawoh Mohamed , Komeh James P. , Johnson Wiltshire C.N 
Published: October 2023

Abstract

Background
National Medicines Regulatory Authorities like the Pharmacy Board of Sierra Leone are responsible for protecting and promoting public health, implementing rigorous regulatory standards, and maintaining an assured supply of medical products that are safe, effective, and of good quality. This retrospective study assesses the quality improvement of the Pharmacy Board of Sierra Leones’ processes and the influence of internal and external audits on the quality management system and services provided to customers.
Methods
Data was collected on identified counterfeit drugs from 2013 to 2021 using a data collection tool prepared to collate relevant information that could address the different objectives. All data were sourced from the Department of Quality Assurance and the Department of Enforcement and Narcotics at the Pharmacy Board of Sierra Leone. Internal audit records from 2016 to 2020 and external audit reports from external auditors and the World Health Organisation Global benchmarking self-assessment tool were also used.
Results
The study showed marked changes in identifying counterfeit drugs by the Pharmacy Board of Sierra Leone post-ISO 9001:2015 certification compared to yearly Pre-ISO 9001:2015 certification. Critical functions of the Pharmacy Board of Sierra Leone from 2016 to 2021 showed that several indicators had been addressed post-ISO9001:2015 certification and an improvement in the level of maturity for the quality assurance (Regulatory systems) and Pharmacovigilance functions. There was also an improvement in addressing the number of identified non-conformances from internal and external audits post-ISO9001:2015 certification.
conclusions
This study revealed that regular checks through self-assessment, internal audits and standard management review meetings that generate followed up timelines and corrective actions for non-conformances are essential quality improvement tools for the efficient functioning of the Pharmacy Board of Sierra Leone.
Marginal vs average curtailment of renewables and access conditions in Renewable Energy Zones
Authors: Newbery David , Simshauser Paul 
Published: October 2023

Abstract

Most countries have set challenging decarbonisation targets that will require high levels of Variable Renewable Electricity (VRE). The ratio of peak to average production is from 2-4 for wind and 4-11 for PV and so once market shares reach 50%, curtailment will be necessary, even if delayed by storage and exports. This article demonstrates theoretically and from market experience that marginal curtailment rates (the extra curtailment caused by the last MW installed) will be at least 3 times average curtailment rates. Free entry will be driven by average curtailment rates while in a fully efficient market without development constraints, entry should be driven by marginal curtailment. The article discusses possible policy and market design options to address this discrepancy and argues nevertheless for a pragmatic solution that decides capacity using marginal curtailment rates but encourages optimal entry levels using average curtailment, given the limits of infrastructure expansion.
JEL Codes: D52, D53, G12, L94, Q40
PAM-Actuated Manipulator Performance Enhancement Based on Synergetic Algorithm Control Theory and Social Spider Optimization Algorithm
Authors: Hasan Alaq F. , Raheem Hadeer A. , Hussein Rajaa 
Published: October 2023

Abstract
The PAM-actuated manipulator is a widely used type of robotic arm in industrial automation. However, its performance can be limited by non-linear dynamics and uncertainties in the system. To overcome these limitations, this paper proposes a synergetic control strategy based on the social spider optimization algorithm. The synergetic control approach allows for the coordination of multiple actuators to achieve a desired trajectory, while the social spider optimization algorithm (SSO) optimizes the control parameters to improve the overall performance.
A computer simulation study was conducted using MATLAB software to compare the performance of optimal Synergetic Algorithm Control Theory (SACT) and optimal Sliding Mode Controller (SMC). Both controllers were applied to a non-linear system with uncertainties. The provided simulation results have shown that the SACT controller performs much better than the SMC controller regarding tracking accuracy and uncertainty robustness. The SACT controller exhibited quicker convergence towards the desired trajectory and maintained a lower steady-state error as compared to the SMC controller. Additionally, the SACT controller demonstrated more resilience to variations in parameters and possessed more robust characteristics.
Analysis of common genetic variation of anxiety disorders in essential tremor
Authors: Yan Yaping , Cao Lanxiao , Gu Luyan , Xu Congying , Lu Jinyu , Lv Dayao , Tian Jun , Yin Xinzhen , Pu Jiali , Zhang Baorong , Zhao Guohua 
Published: October 2023

Abstract
Objective
To explore the association of common genetic variation of anxiety disorders and essential tremor (ET).
Methods
We genotyped 25 anxiety-specific risk variants in a cohort of 478 unrelated ET patients and 505 age and gender-matched healthy controls from eastern China using a MassARRAY system. The association between candidate variants and ET patients were evaluated using gene-based analysis.
Results
A total of 159 patients (33.3%) had at least mild anxiety. In genotypic analysis, rs1187280 (NTRK2 gene), rs3807866 (TMEM106B gene), rs6557168 (ESR1 gene) and rs708012 (in an intergenic region) in the dominant models and rs1187280 (NTRK2 gene), TMEM106B rs3807866, rs708012 and rs7528604 (PDE4B) under the recessive model were found to be significantly associated with ET. In allelic analysis, the carriers of C allele of NTRK2 rs1187280, T allele of TMEM106B rs3807866, A allele of ESR1 rs6557168 and T allele of rs708012 occupy a larger proportion of ET patients compared with healthy controls.
Conclusion
Anxiety-specific risk SNPs of TMEM106B rs3807866 and ESR1 rs6557168 increase the risk for ET, while two SNPs of NTRK2 rs1187280 and rs708012 show a protective role.