bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent advance in modification strategies and applications of soy protein gel properties
Authors: Liang Peijun , Chen Simin , Fang Xiang , Wu Jianfeng 
Published: December 2023

AbstractSoy protein gel can be developed into a variety of products, ranging from traditional food (e.g., tofu) to newly developed food (e.g., soy yogurt and meat analog). So far, efforts are still needed to be made on modifying the gel properties of soy protein for improving its sensory properties as animal protein‐based food substitutes. Furthermore, there is always a need to regulate its gel properties for designing novel and tailored products of soy protein gels due to the fast‐growing plant protein‐based product market. This review gave an emphasis on the latest modification strategies and applications of gel properties of soy protein. The modifying methods of soy protein gel properties were reviewed from an aspect of composition or processing. Compositional modification included changing protein composition and gelling conditions and using additives, whereas processing strategies can be achieved through physical, chemical, and enzymatic treatments. Several compositional modification and processing strategies have been both proven to alter the gel properties of soy protein effectively. So far, soy protein gel has been applied in the field of food and biomedicine. In the future, more mechanistic studies on the modification methods are still needed to facilitate the full application of soy protein gel.
Incidence of beak deformities in austral thrushes (Turdus falcklandii) increases with urbanization and flocking behavior
Authors: GOROSITO Cristian Andres , JAHN Alex Edward , CUETO Victor Rodolfo 
Published: December 2023

AbstractBeak deformation, known as avian keratin disorder (AKD), can impair feeding and preening of birds, reducing their survival. This disorder is apparently caused by Poecivirus infection, although to date, the viral origin has been corroborated in only a few North American bird species. Considering that fruit‐eating birds can track spatiotemporal variations in fruit abundance and that AKD may have a viral origin, the incidence of this disease can be expected to increase with flocking by birds. Therefore, we evaluated if austral thrushes (Turdus falcklandii) were attracted to urban areas when exotic plants offered fruits and if flocking of thrushes in urban areas increased the spread of AKD in this species in a Patagonian town. We fitted GPS loggers on some individuals with normal beaks in rural areas and found that they visit the town in fall. Through point count censuses, we recorded greater abundances of thrushes with normal and deformed beaks during fall–winter in urban sites than in rural sites. However, the abundance of birds with AKD declined more (78–87%) than that of individuals with normal beaks (44–52%) during the transition from fall–winter to spring–summer. In urban zones in our study area, fruits of exotic species ripen during fall, attracting austral thrushes from rural sites. Nevertheless, such an attraction for food resources may be an ecological trap for this species, as the increase in incidence of AKD in urban areas may drastically reduce the survival of birds during the most unfavorable period of the year.
Chronic post‐surgical pain following gastrointestinal surgery: Protocol for a scoping review
Authors: Rosendahl Amalie , Thomsen Thordis , Brandstrup Birgitte , Møller Ann M. 
Published: December 2023

AbstractBackgroundChronic post‐surgical pain (CPSP) significantly impacts people's lives, affecting both socioeconomic aspects as well as their rehabilitation after surgery. Yet, CPSP remains an under‐researched field. The prevalence varies depending on type of surgery, which highlights the importance of surgery‐specific research. This scoping review aims to investigate CPSP following gastrointestinal surgery in order to map out incidences, risk factors, and impact on quality of life (QoL) as well as identify gaps in research.MethodsThe planned review will follow the Preferred Reporting Items for Systematic review and Meta‐Analyses (PRISMA) for Scoping Review guidelines. A search strategy will be carried out in major peer‐reviewed databases and grey literature will be sought and identified. We will include original studies assessing CPSP after gastrointestinal surgery, with the exception of hernia surgery. We will chart data regarding trial characteristics, patient demographic, surgical diagnosis, risk factors, follow‐up times, pain definitions and evaluations as well as impact on QoL.ResultsWe will present the included studies with a narrative summary, supplemented with descriptive statistics of the quantitative data if appropriate.ConclusionThe planned scoping review will map out the current evidence about CPSP in adults following gastrointestinal surgery. We will identify gaps in research that can support the development of further research into CPSP after gastrointestinal surgery.
Coping strategies used by second‐career student teachers
Authors: van Heijst Ilona , Volman Monique , Cornelissen Frank 
Published: December 2023

AbstractBackgroundWhen second‐career teachers (SCTs) learn to teach, they need to cope with the tension‐evoking moments they encounter. Little is known about the coping strategies SCTs use to manage tensions.AimThe purpose of this study was to investigate the coping strategies SCTs use during the first 1.5 years of teacher training. The SCTs' own perceptions about the usefulness, evolution and specificity of these coping strategies were also studied.SampleTwenty‐four SCTs in the alternative teacher training programme (ATTP) at the University of Amsterdam participated in this study. These SCTs aspired to become teachers of mathematics, physics, economics, computer science or chemistry.MethodFor each participant, written logbook fragments and interviews were analysed in Atlas‐ti.ResultsThe SCTs used in decreasing order: intrapersonal approaching (e.g., resolving problems autonomously), interpersonal approaching (e.g., consulting others) and intrapersonal avoiding strategies (e.g., ignoring an undesired situation). Interpersonal avoiding strategies were not mentioned at all.While the SCTs reported approaching strategies (inter‐ and intrapersonal) as being useful for their development, we also found disadvantages to intrapersonal approaching strategies and advantageous uses of avoiding strategies. The SCTs noted several inter‐ and intrapersonal approaching coping strategies that they considered typical for SCTs.ConclusionIntrapersonal approaching coping strategies can be a risk because of the invisibility of these strategies. Interpersonal strategies should be stimulated because SCTs benefit from the social network in school. Avoiding strategies may serve a purpose for managing the complexity of the teaching profession.
Metadherin inhibits chemosensitivity of triple‐negative breast cancer to paclitaxel via activation of AKT/GSK‐3β signaling pathway
Authors: Chang Yan , Jia Hui‐Qin , Xu Bin , Yang Liu , Xu Ye‐Tong , Zhang Jing‐Yu , Wang Mei‐Qi , Yang Li‐Xian , Song Zhen‐Chuan 
Published: December 2023

AbstractTriple‐negative breast cancer (TNBC) has an aggressive clinical course, and paclitaxel (PTX)‐based chemotherapy remains the main therapeutic drug. Metadherin (MTDH) acts as an oncogene that regulates proliferation, invasion, metastasis, and chemoresistance. This study aimed to investigate whether TNBC chemosensitivity to PTX was related to the MTDH/AKT/glycogen synthase kinase‐3beta (GSK‐3β) pathway. Clinical baseline characteristics and immunohistochemistry (IHC) were used to evaluate the expression and prognosis of MTDH and AKT (protein kinase B, PKB) in TNBC patient samples. MTDH shRNA, MTDH overexpression vector, MK‐2206, and PTX intervention were used in cell models and mouse tumor‐bearing models. Afterwards, mRNA and protein levels were assessed using quantitative real‐time polymerase chain reaction and Western blot. Evaluate the level of tumor cell apoptosis and cell cycle using flow cytometry. Cell viability was detected using Cell Count Kit 8. The in vivo imaging system is used to analyze the growth of tumors. We found that higher expression of MTDH or AKT resulted in poorer disease‐free survival and a lower Miller–Payne grade. MTDH promotes cell proliferation and increases p‐AKT and p‐GSK‐3β expression in TNBC cells. Notably, suppression of AKT terminated MTDH overexpression‐induced cell proliferation and apoptosis. MTDH knockdown or the AKT inhibitor MK2206 reduced the p‐AKT and p‐GSK‐3β ratio, reduced cell viability and proliferation, increased cell apoptosis, and increased chemosensitivity to PTX. In vivo, xenograft tumors of an MTDH knockdown+MK2206 group treated with PTX were the smallest compared to other groups. In short, MTDH inhibits TNBC chemosensitivity to PTX by activating the AKT/GSK‐3β signaling pathway.
A mother and her daughter carrying a pathogenic expansion of the HTT gene with a phenotype encompassing motor neuron disease and Huntington's disease
Authors: Canosa Antonio , Cabras Sara , Di Pede Francesca , Manera Umberto , Vasta Rosario , Moglia Cristina , Calvo Andrea , Gallone Salvatore , Chiò Adriano 
Published: December 2023

AbstractRecently, pathogenic expansions (range 40–64 CAG repeats) in the HTT gene have been found in patients diagnosed with pure frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS). We report a mother with Huntington's disease (HD) associated with motor neuron disease (MND) signs and her daughter suffering from ALS with subtle signs of HD, both carrying a pathogenic allele of the HTT gene (i.e., >39 repeats). The co‐occurrence of MND and chorea has been reported in previous cases. Subjects showing both ALS and HD signs and carrying HTT pathogenic expansions in two generations of the same kindred have never been reported so far. The study of the overlap of disease mechanisms at the cellular level between TDP‐43 and Huntingtin is relevant in an era offering promising strategies of targeted treatments in neurodegenerative disorders.
Neurite density of the hippocampus is associated with trace eyeblink conditioning latency in 4‐ to 6‐year‐olds
Authors: Vieites Vanessa , Ralph Yvonne , Reeb‐Sutherland Bethany , Dick Anthony Steven , Mattfeld Aaron T. , Pruden Shannon M. 
Published: December 2023

AbstractLimited options exist to evaluate the development of hippocampal function in young children. Research has established that trace eyeblink conditioning (EBC) relies on a functional hippocampus. Hence, we set out to investigate whether trace EBC is linked to hippocampal structure, potentially serving as a valuable indicator of hippocampal development. Our study explored potential associations between individual differences in hippocampal volume and neurite density with trace EBC performance in young children. We used onset latency of conditioned responses (CR) and percentage of conditioned responses (% CR) as measures of hippocampal‐dependent associative learning. Using a sample of typically developing children aged 4 to 6 years (N = 30; 14 girls; M = 5.70 years), participants underwent T1‐ and diffusion‐weighted MRI scans and completed a 15‐min trace eyeblink conditioning task conducted outside the MRI. % CR and CR onset latency were calculated based on all trials involving tone‐puff presentations and tone‐alone trials. Findings revealed a connection between greater left hippocampal neurite density and delayed CR onset latency. Children with higher neurite density in the left hippocampus tended to blink closer to the onset of the unconditioned stimulus, indicating that structural variations in the hippocampus were associated with more precise timing of conditioned responses. No other relationships were observed between hippocampal volume, cerebellum volume or neurite density, hippocampal white matter connectivity and any EBC measures. Preliminary results suggest that trace EBC may serve as a straightforward yet innovative approach for studying hippocampal development in young children and populations with atypical development.
Breed predispositions to congenital and juvenile cataracts in horses at two academic institutions
Authors: Plotsker Noah M. , Bellone Rebecca R. , Ledbetter Eric C. , Irby Nita L. , Good Kathryn L. , Knickelbein Kelly E. 
Published: December 2023

AbstractBackgroundDetermination of horse breeds predisposed to congenital and juvenile cataracts will enable investigations into potential genetic mechanisms for cataracts in horses.ObjectiveTo investigate horse breed predispositions to congenital and juvenile cataracts in two academic referral populations.Study designRetrospective case series.MethodsMedical record identification of horses diagnosed with congenital or juvenile cataracts at the Cornell University Equine Hospital (2000–2022) and the University of California‐Davis (UCD) Large Animal Clinic (1990–2021). Signalment, examination findings and treatments were recorded. Descriptive statistics were performed, and breed over‐representations were determined using Chi‐squared or Fisher's exact tests.ResultsThirty‐one (Cornell) and 70 (UCD) horses with congenital or juvenile cataracts were identified, for a total of 101 affected horses. Seventy‐eight horses were affected bilaterally and 23 were affected unilaterally, for a total of 179 affected eyes. Standardbreds were significantly over‐represented at both institutions, comprising 32.5% of congenital/juvenile cataract cases and 10% of the equine hospital population at Cornell (p < 0.001) and 4.3% of cataract cases and 1.3% of the equine hospital population at UCD (p = 0.03). Thoroughbreds were under‐represented for congenital and juvenile cataracts at both institutions (p = 0.03 Cornell, p = 0.01 UCD).Main limitationsRetrospective study, potential for selection bias.ConclusionsThe over‐representation of the Standardbred breed for congenital and juvenile cataracts at two institutions suggests an underlying genetic basis in the breed. Future genetic and genomic studies are warranted to investigate heritable cataracts in Standardbred horses.
Face‐to‐face: isotretinoin use and pregnancy outcome
Authors: Tırmıkçıoğlu Zeynep , Tatlıparmak Aslı 
Published: December 2023

AbstractIsotretinoin has been used to treat severe acne for more than 40 years. There are no accurate data on the absolute risk of potential teratogenicity to all fetuses exposed to isotretinoin. According to current guidelines, isotretinoin should be discontinued at least 1 month before pregnancy. This study enrolled pregnant women who contacted the Clinical Pharmacology and Toxicology Unit for individual drug risk assessment between 2016 and 2020. Data on maternal characteristics and isotretinoin exposures were obtained at first consultation. After delivery, follow‐up calls were conducted using a structured questionnaire. Of 2,323 pregnant women consulted, 1.3% (31/2,323) had systemic isotretinoin exposure during and before pregnancy. Of 31 prospectively followed pregnancies, eight terminated electively. Most elective terminations (7/8) were performed because of the fear of fetal malformation. The majority of continued pregnancies (16/23) resulted in healthy live birth. There were no major birth defects. In six pregnancies, intrauterine deaths (three first trimester, three second trimester) were reported. Cesarean section was performed in 70.5% (12/17) of all deliveries. The median gestational age at birth was 39, and no preterm births were reported. Local isotretinoin treatments in six cases were evaluated and presented additionally, and all babies were born healthy. Based on the results of this study, there was no evidence of major birth defect, mental disorder, or retinoid embryopathy associated with the use of isotretinoin in pregnancy. Not local use, but systemic exposure to isotretinoin is of great concern that results in pregnancy termination.
Leptin and adiposity measures from birth to later childhood: Findings from the Hyperglycemia and Adverse Pregnancy Outcomes Follow‐Up Study
Authors: DeLacey Sean , Gurra Miranda , Arzu Jennifer , Lowe Lynn P. , Lowe William L. , Scholtens Denise M. , Josefson Jami L. 
Published: December 2023

SummaryBackgroundCord blood (CB) leptin is positively associated with adiposity at birth, but the association with child adiposity is unclear.ObjectivesWe hypothesized that CB leptin is positively associated with adiposity in peripubertal children and with childhood leptin.MethodsLeptin was measured in 986 CB and 931 childhood stored samples from a prospective birth cohort. Adiposity measures were collected at birth and mean age 11.5 years. Linear and logistic regression analyses were used to evaluate associations between log‐transformed CB leptin and neonatal and childhood adiposity measures as continuous and categorical variables, respectively.ResultsCB leptin was positively associated with neonatal and childhood adiposity. Childhood associations were attenuated when adjusted for maternal body mass index (BMI) and glucose, but remained statistically significant for childhood body fat percentage (β = 1.15%, confidence interval [CI] = 0.46–1.84), body fat mass (β = 0.69 kg, 95% CI = 0.16–1.23), sum of skin‐folds (β = 1.77 mm, 95% CI = 0.31–3.24), log‐transformed child serum leptin (β = 0.13, 95% CI = 0.06–0.20), overweight/obesity (OR = 1.21, 95% CI = 1.03–1.42), obesity (OR = 1.31, 95% CI = 1.04–1.66) and body fat percentage >85th percentile (OR = 1.38, 95% CI = 1.12–1.73). Positive associations between newborn adiposity measures and CB leptin confirmed previous reports.ConclusionCB leptin is positively associated with neonatal and childhood adiposity and child leptin levels, independent of maternal BMI and maternal hyperglycemia. CB leptin may be a biomarker of future adiposity risk.
Intention to stay of pediatric nurses: Does pediatric nurse–parent partnership and perceived stress matter?
Authors: Ji Jianlin , Guo Ningyuan , Cengqian Zeng , Lu Qunfeng , Wang Lin 
Published: December 2023

AbstractAimsTo explore intentions to stay of pediatric nurses and to determine how pediatric nurse–parent partnership and perceived stress differ among the subgroups.Background and introductionThe shortage of nurses, particularly pediatric nurses, has become a global problem. Intention to stay has been an established predictor of nurse retention. Less is known about the heterogeneity of intention to stay and the specific characteristics, which may restrict the effectiveness of prevention and interventions for pediatric nurse retention.MethodsThis was a cross‐sectional online survey. A total of 603 pediatric nurses were surveyed on their pediatric nurse–parent partnership, perceived stress, and intention to stay. Latent class analysis, multinomial logistic regression, and univariate analysis were used to analyze the related factors. We followed the STROBE checklist.ResultsThree latent classes of intention to stay were identified: low level, moderate level, and high level. Aged between 31 and 35, higher perceived stress, contract nurse, and no spouse were associated with the low level of intention to stay. Good sensitivity in the pediatric nurse–parent partnership was associated with high level of intention to stay. Having a spouse was associated with moderate level compared with low level of intention to stay.Discussion and conclusionOur study was one of the first to show three different classes of intention to stay of pediatric nurses, and the specific sociodemographic information, perceived stress, and pediatric nurse–patient partnership associated with different classes of intention to stay were reported.Implications for nursing and/or health policyOur results informed the development of pediatric nurse support strategies. Nurse managers could consider the specific factors affecting the intention to stay and make great efforts in developing strategies and projects for different classes of intention to stay that can maximize nurse intention to stay.
Effect of endoscopic mucosal resection and endoscopic submucosal dissection on postoperative wound complications in patients with gastric cancer: A meta‐analysis
Authors: Liu Xiaoyun , Wu Xia , Fan Wenjun 
Published: December 2023

AbstractEndoscopic submucosa dissection (ESD) allows complete excision of the whole lesion, which results in a higher percentage of complete excision and an improved quality of life by minimizing the amount of excision as opposed to an endoscopic mucosal resection (EMR). Although ESD is now being carried out in the majority of hospitals, ESD's possible complications (such as trauma and perforation) have given rise to doubts about ESD practices in patients with early‐stage stomach cancer when deciding on therapy and reimbursement. This study was designed to evaluate the effectiveness and safety of ESD over EMR in treating early‐stage stomach cancer. Four main databases have been searched, including EMBASE and published. The ROBINS‐I tool suggested in the Cochrane Handbook has been applied to evaluate the quality of the chosen trials. It may better reflect the risk of bias in the included studies. The meta‐analyses were carried out with ReMan 5.3, and the results were treated with endote. Seven cohort studies have been completed. Meta analysis indicated that EMR and ESD surgery did not differ significantly from each other in terms of postoperative haemorrhage (OR, 0.76; 95%CI, 0.56,1.04 p = 0.09); EMR, however, was associated with a lower rate of postoperative perforation than ESD surgery (OR, 0.36; 95%CI, 0.24,0.54 p < 0.0001). Taking into account that ESD and EMR did not differ significantly in the risk of wound bleeding, even though the risk of perforation is not likely to result in life‐threatening illness. In the analysis of these data, however, the potential advantages of EMR might be greater than ESD.
Promoting thermal stability and acid resistance of rare earth sulfide powders by coating ZnO and SiO2 double shells
Authors: Li Renhan , Bai Gongxun , Zhang Hongbin , Song Enhai , Zhang Jiasong , Li Denghao , Zhang Junjie , Xu Shiqing 
Published: December 2023

AbstractAs an environment‐friendly powder with good coloring performance, rare earth sulfide is one kind of the important choices to replace cadmium and lead colorants. In particular, γ‐Ce2S3 belongs to rare earth sesquisulfide, which has a bright red color. However, the uncoated γ‐Ce2S3 is easy to decompose and release H2S in a humid or acidic environment, and its air thermal stability is limited to 350°C. In this work, γ‐Ce2S3 powders coated with zinc oxide were prepared by heterogeneous precipitation method, and a dense protective layer was formed by ZnO to improve chemical and thermal stability. Moreover, silicon dioxide was deposited on the surface of the zinc oxide coating using the microemulsion process to strengthen the powder's acid resistance. The double shells structure greatly promoted thermal stability and acid resistance of γ‐Ce2S3 powders. The results showed that rare earth sulfide powders with double shells have good stability for coloring applications.
Self‐injurious behavior in individuals with intellectual and developmental disabilities: An interdisciplinary family systems review
Authors: Roberts Caroline L. , Symons Frank 
Published: December 2023

AbstractThis conceptual review paper takes an interdisciplinary approach to the study of self‐injury in families. The overall goal is to begin integrating siloed bodies of knowledge from empirical work based on findings from individuals with and without intellectual and developmental disabilities and self‐injury. The research literature on self‐injury and family‐level variables is reviewed, including dyadic and individual‐level variables with potential bidirectional impact on the family. Then, opportunities for knowledge translation are explored with respect to the pragmatic goal of developing family‐level interventions for self‐injurious behavior in individuals with intellectual and developmental disabilities. Four opportunities for knowledge translation are highlighted: family patterns, parenting behavior, attachment relationships, and emotional experience.