bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival nomogram for medulloblastoma and multi-center external validation cohort
Authors: Li Xiang , Gong Jian 
Published: November 2023

Background: Medulloblastoma (MB) is a highly malignant neuroepithelial tumor occurring in the central nervous system. The objective of this study was to establish an effective prognostic nomogram to predict the overall survival (OS) of MB patients.Materials and methods: The nomogram was developed using data from a retrospective cohort of 280 medulloblastoma patients (aged 3–18 years) identified from Beijing Tiantan Hospital between 2016 and 2021 as the training cohort. To validate the performance of the nomogram, collaborations were formed with eight leading pediatric oncology centers across different regions of China. A total of 162 medulloblastoma patients meeting the inclusion criteria were enrolled from these collaborating centers. Cox regression analysis, best subsets regression, and Lasso regression were employed to select independent prognostic factors. The nomogram’s prognostic effectiveness for overall survival was assessed using the concordance index, receiver operating characteristic curve, and calibration curve.Results: In the training cohort, the selected variables through COX regression, best subsets regression, and Lasso regression, along with their clinical significance, included age, molecular subtype, histological type, radiotherapy, chemotherapy, metastasis, and hydrocephalus. The internally and externally validated C-indexes were 0.907 and 0.793, respectively. Calibration curves demonstrated the precise prediction of 1-, 3-, and 5-year OS for MB patients using the nomogram.Conclusion: This study developed a nomogram that incorporates clinical and molecular factors to predict OS prognosis in medulloblastoma patients. The nomogram exhibited improved predictive accuracy compared to previous studies and demonstrated good performance in the external validation cohort. By considering multiple factors, clinicians can utilize this nomogram as a valuable tool for individualized prognosis prediction and treatment decision-making in medulloblastoma patients.
Retrospective study of tetanus in 18 dogs—Causes, management, complications, and immunological status
Authors: Dörfelt Stefanie , Mayer Christine , Wolf Georg , Straubinger Reinhard K. , Fischer Andrea , Hartmann Katrin , Dörfelt Rene 
Published: November 2023

ObjectiveTetanus is a severe neurologic disease caused byClostridium tetani, resulting in spastic paralysis. Canine tetanus is associated with serious complications such as aspiration and a high mortality rate of up to 50%.Materials and methodsMedical records of all dogs diagnosed with tetanus over 8 years (2014–2022) were analyzed for severity grade, treatment protocols, nutritional management, and complications, as well as outcome, vaccination, and antibody production in some dogs. No medical records were excluded. Normality was analyzed by the D'Agostino–Pearson test. Parametric, normally distributed data were presented as mean ± standard deviation. Non-parametric, non-normally distributed data were presented as median (m) and range (minimum–maximum). The association between tetanus grade, progression of diseases, and duration of hospitalization was analyzed using thet-test, Mann–Whitney U test, and Kruskal–Wallis test. AP≤ 0.05 was considered significant.ResultsEighteen dogs were identified. Most affected dogs were classified into severity grade II (66.7%, 12 of 18). Clinical signs deteriorated in 55.6% of dogs (10 of 18). A source was identified in 88.9% of dogs (16 of 18). Nine dogs required surgical wound revision. A percutaneous endoscopic gastropexy tube was placed in 83.3% of dogs (15 of 18) for nutritional support. Medical treatment included metronidazole, methocarbamol, and combinations of different sedatives adapted to the patient's requirements. Tetanus antitoxin was used in 72.2% of dogs (13 of 18) without reported adverse events. The survival rate was 88.9% (16 of 18). Complications, such as hypertension, aspiration pneumonia, and laryngeal spasm occurred in 12 of 18 dogs. Median hospitalization time (8 days; range 0–16 days) was associated with the maximum tetanus severity grade (p = 0.022). Rapid eye movement behavior disorder was observed in 72.2% of dogs (13 of 18). In 5 dogs, antibodies were measured after recovery, and in 4 of 5 dogs, no antibodies were detectable despite generalized tetanus disease. Vaccination with tetanus toxoid was performed in five dogs following the disease.ConclusionIn the present study, the mortality rate was lower than previously reported. Tetanus is still a life-threatening disease, but the prognosis may be good if adequate management and monitoring can be ensured.
Frass from Black Soldier Fly Larvae, Hermetia illucens, as a Possible Functional Dietary Ingredient in Channel Catfish Feed
Authors: Yıldırım-Aksoy Mediha , Eljack Rashida , Aksoy Janset , Beck Benjamin H. 
Published: November 2023

Frass–the by-product of the larva meal industry–was recently shown to be a sustainable ingredient for use in diets of several fish species. Additionally, because of its possible immunomodulatory activity and anti-microbial properties, frass may have great potential as an organic method of pathogen control in aquaculture. Five diets containing 0, 5, 10, 20 and 30% frass from black soldier fly larvae, Hermetia illucens, were fed to channel catfish (5.24 ± 0.04 g) in quadruplicate aquaria to apparent satiation twice daily. At the end of the 10-week feeding trial, blood samples were collected from all groups to measure hematological and immune parameters, and to determine the effects of dietary frass on resistance to Flavobacterium covae infection. Hematological parameters (red blood cell count, hemoglobin, and hematocrit)—but not white blood cell count—were improved with the inclusion of frass. Serum glucose levels were significantly lower in fish on the diet with frass than fish on the diet without frass. Fish fed the highest dietary levels of frass (30%) had a significantly higher serum cholesterol level than fish on the control diet. Serum complement activity was significantly higher in fish on diets containing frass at levels of 10% and 20%. No significant differences were observed in other measure serum components including albumin, alkaline phosphatase, alanine aminotransferase, amylase, calcium, phosphorus, potassium, total protein, globulin, thyroxine and lysozyme activity. Even though overall mortality was low (0–17%), fish on the diets containing frass at levels 20% or more showed significantly higher survival than that of control fish or fish on lower levels of dietary frass. The use of frass in the catfish diet may prove beneficial by improving hematological parameters, and select serum immune effectors, and the overall resistance of juvenile channel catfish against F. covae infection.
La meilleure formation consiste à réfléchir sur sa pratique
Authors: Rouxel Marie Thérèse 
Published: November 2023

Solidarité Français Migrants (1) est une Association type loi 1901. Créée en novembre 1975, elle est agréée d’Education Populaire.
Ses buts sont d’établir une compréhension et une communication véritables entre français et immigrés. Elle vise à une éducation à la responsabilité, et cherche à promouvoir l’égalité des chances et des droits. Elle touche un public de femmes et d’enfants, mais atteint aussi des familles par le biais des actions de quartier et par l’action «vacances familiales ».
Depuis août 1976, elle est subventionnée par le F.A.S.
S.F.M. assure une formation continue pour tous ses membres, bénévoles et salariés, en matière d’animation et de formation d’adultes.
HIRADC Analysis for Rolling Stock Body Lifting Ngrombo Railway Maintenance Center
Authors: Riyanta Wawan 
Published: November 2023

The Railway Maintenance Center as stated in the Regulation has the duty and function of carrying out the maintenance of state-owned railway facilities. The part of rolling stock heavy maintenance with high potential hazard is Lifting Body Activities Using OHTC in Maintenance of Hydraulic Diesel Locomotive Facilities activity. it so there is a need for a risk assessment which is a process to determine control priorities for the level of risk work accident or occupational disease. Part of OHSAS 18001:2007 Clouse 4.3.1. recommendation HIRADC methode for can support a safety system with 3 stage analisys (hazard identification, risk assessment, and control determination) The Hazard Identification results obtained 3 aspects of hazard risk in OHTC Rolling stock Body Lifting operations with the following analysis results Crane toppling, Equipment failure, Load falling with Death & asset / property damage impact factor. Risk Assessment analisys of Rolling stock Body Lifting using OHTC obtained results action taken when resources are available regarding handling which in general were Administrative Control. Determine Control relevant steps to minimize potential hazards immediately (1) Evaluating SOP Rolling stock Body Lifting and conduct outreach to all employees related to the work, (2) Making and or adding hazard signs and (3) Human development by conducting Training/Refreshment Crane Operator and Signal man. (4) Strictness of the rules for using PPE for all employees related to the work as the last step in minimizing the risk of occupational hazards.
Transformasi Cerita Rakyat "Asal-Usul Hayam Pelung" ke dalam Cerita Bergambar
Authors: Ningsih Dissa Sri Nurlaili , Maryam Siti , Adawiyah Aprilla 
Published: November 2023

This article describes the process of transforming the folk tale "Asal-usul Hayam Pelung” into a pictorial story, so that folk tales in oral form are more attractive to the younger generation. The research was carried out descriptively qualitatively, with data collection techniques through library studies. The transformation process was carried out through internal changes. drama scripts and scripts into pictures. At the stage of transformation into pictures, the results are only modified character elements, while the plot, setting and scenes remain the same. Modifications are in the form of changing character elements, namely the addition of three characters (Kang Ahsan, Abdul, and Ustaz Rakhmat ). Illustrating the characters, giving rise to 5 characters, namely Mama Djarkasih, Kang Ahsan, Abdul, Ustaz Rakhmat, and Ayam Pelung. The results of the transformation of the illustrated story. “Asal-usul Hayam Pelung” from the story underwent a change in concept, namely images and text content. This illustrated story can also be used as a alternative teaching media.Keywodrs: Hayam Pelung; folklore; comic; transformationAbstrakArtikel ini mendeskripsikan proses transformasi cerita rakyat Asal-usul Hayam Pelung ke dalam cerita bergambar, sehingga cerita rakyat dalam bentuk lisan lebih diminati generasi muda. Penelitian dilakukan secara kualitatif deskriptif, dengan teknik pengumpulan data melalui studi pustaka. Proses transformasi dilakukan melalui perubahan ke dalam naskah drama dan naskah ke dalam gambar. Pada tahap transformasi ke dalam gambar, diperoleh hasil modifikasi unsur tokoh saja, sementara alur, latar, dan adegan tetap sama. Modifikasi berupa pengubahan unsur tokoh yaitu penambahan tiga tokoh (Kang Ahsan, Abdul, dan Ustaz Rakhmat). Pengilustrasian tokoh, memunculkan 5 tokoh yaitu mama Djarkasih, Kang Ahsan, Abdul, Ustaz Rakhmat, dan ayam pelung. Hasil transformasi cerita bergambar Asal-Usul Ayam Pelung dari cerita mengalami perubahan konsep yaitu gambar dan isi teks. Cerita bergambar ini juga dapat dijadikan alternatif media ajar.Kata Kunci: Ayam Pelung; cerita rakyat; cerita bergambar; transformasi
Interferensi Bahasa Mandailing dalam Pemerolehan Bahasa Indonesia
Authors: Habibi M. , Iskandar Puguh Ardianto , Chandra Chandra , Suriani Ari 
Published: November 2023

This article will explain the Mandailing language interference in Indonesian that occurs among elementary school children in the South Tapanuli area, North Sumatra. The research uses a qualitative approach with a case study type of research. The results of the research show that there have been 8 cases of language interference at the phonological level, 12 cases of interference at the morphological level, 20 cases of interference at the lexicon level, and 7 cases of interference at the syntactic level. The causes of interference are bilingualism, limited vocabulary, rarely used second language vocabulary and carryover of mother tongue habits. The results of this research are useful for teachers in creating a learning environment that familiarizes themselves with the use of a second language, namely Indonesian.Keywodrs: interference; Mandaling; language acquisitionAbstrakArtikel ini akan memaparkan interferensi bahasa Mandailing dalam bahasa Indonesia yang terjadi pada anak SD di daerah Tapanuli Selatan, Sumatera Utara. Penelitian menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus Hasil penelitian menunjukkan telah terjadi interferensi bahasa pada tataran fonologi sebanyak 8 kasus, interferensi pada tataran morfologi sebanyak 12 kasus, interferensi pada tataran leksikon sebanyak 20 kasus, dan interferensi pada tataran sintaksis sebanyak 7 kasus. Penyebab terjadinya interferensi adalah kedwibahasaan, perbendaharaan kosakata yang masih minim, kosakata bahasa kedua jarang digunakan, dan terbawanya kebiasaan bahasa ibu. Hasil penelitian ini bermanfaat bagi guru dalam menciptakan lingkungan belajar yang membiasakan penggunaan bahasa kedua, yaitu bahasa Indonesia.Kata kunci: interferensi; Mandaling; pemerolehan bahasa
COVID-19 Associated Anxiety, Grief, Anger, and Perceived Stress in Individuals with Multiple Sclerosis
Authors: DAĞLI Seda , BAYLAM YİRMİBEŞ Ekin Öykü , AYDEMİR Duygu , YILDIRIM Neslişah , TÜRK Özge , DOĞAN ÜNLÜ Melike , DEMİRCİ Serpil 
Published: November 2023

The COVID-19 pandemic has affected all segments of society. In this study, the level of anxiety, grief, anger and perceived stress related to pandemic conditions were evaluated in multiple sclerosis (MS) cases, healthcare professionals and lay public and, the stress experienced by individuals with MS was compared with health care professionals and lay public.
Study sample were composed of 63 persons with MS, 59 healthcare professionals (HCP), and 99 healthy volunteers (HV). All participants were administered UCLA-Covid-19 screening test, Posttraumatic Stress Disorder - symptom checklist, Patient Health Questionnaire-9, Generalized Anxiety Disorder-7 Scale, Impact of Events Scale, K-10 scale and Trait Anger Scale. Socio-demographic features of the groups were almost same except for female preponderance and relatively low education in MS group. Hospitalization, test-positivity and quarantine rates due to COVID-19 did nor differ among groups. Pandemic conditions have made everyone feel helpless and hopeless, however, this was remarkably much more evident in HCPs. The most significant concern related with COVID-19 was contracting the disease for persons with MS, transporting the disease to their family members for HCP, and job/income loss due to lockdown for HVs. The stress level experienced by individuals with MS and health care professionals was significantly higher than that of healthy volunteers. In a similar way, the perceived stress level was the same in MS and HCP groups, but significantly higher than in the HV group. Persons with MS were as anxious and depressed as HCPs. Nevertheless, HVs stated that they experienced more psychological distress than both HCPs and persons with MS. Our results yield that depression, anxiety and stress were high among persons with MS during the pandemic.
Clinical Insights into Internuclear Ophthalmoplegia: A Case Report
Authors: Rahmadiansyah Muhammad Fadhil , Muhammad Hidayat  
Published: November 2023

Background: Internuclear ophthalmoplegia (INO) is a rare neuro-ophthalmological disorder characterized by impaired horizontal eye movement coordination due to lesion in the medial longitudinal fasciculus. INO commonly results from demyelinating diseases, vascular lesions, or structural brain abnormalities.
Case presentation: A 60-year-old male patient presented with diplopia for the past 4 days. He had history of hypertension and diabetes mellitus and “mild” stroke for past years. Clinical examination revealed normal primary gaze, limited medial movement of the left eye, and diplopia in all gaze positions. Hess screen examination demonstrated underaction of the left medial rectus muscle and overaction of the right lateral rectus muscle. The laboratory results an elevated blood sugar level. Brain CT scan revealed multiple infarcts in the right parietal and cerebellar lobes and left parieto-occipital lobe, with evidence of brain atrophy. The patient was diagnosed with INO. Management involved addressing the underlying systemic diseases, namely diabetes and hypertension, in collaboration with internist and neurologist. The patient also received citicoline therapy and underwent regular follow-up. In the third-month follow-up, the patient demonstrated significant improvement, with reduction in diplopia and enhancement in left eye medial movement.
Conclusion: This case report highlights the importance of considering INO in patients presenting with diplopia and a history of vascular risk factors. Timely diagnosis and comprehensive management with regular follow-up is crucial to monitor the progress and enhance the patient's quality of life.
Outcomes after intraoperative photodynamic therapy in the combined treatment of locally advanced colon cancer
Authors: Krochek I. V. , Ibatullin R. D. , Lappa A. V. , Anchugova A. E. 
Published: November 2023

Purpose. To study outcomes after the combined treatment of locally advanced colon cancer with intraoperative photodynamic therapy. Materials and methods. 35 patients with locally advanced colon cancer were included in the trial. Patients from the main group (n = 17) had intraoperative photodynamic therapy in combination with elective surgery. Patients from the control group (n = 18) had only surgical treatment. For photodynamic therapy, photosensitizer Photolon and “Lakhta-Milon” diode laser with wavelength 662 nm and power up to 2.5 W were used. Laser light was delivered via a quartz polymer fiber with diameter 600 microns. Results and discussion. Better positive immediate and long-term outcomes were registered in patients with locally advanced colon cancer from the main group, if to compare with the control group (length of hospital stay, number of remissions, relapses and mortality). Conclusion: Intraoperative photodynamic therapy improves outcomes after the combined treatment of patients with locally advanced colon cancer.
Constraining the Structure under Lunar Impact Basins with Gravity
Authors: Smith David E , Goossens Sander , Neumann Gregory A , Zuber Maria T 
Published: November 2023

Abstract
The lunar gravity field is used to estimate and constrain the depth of mass anomalies under 19 major lunar impact basins. We use radial gravitational spectra, consisting of accelerations computed either per spherical harmonic degree or cumulatively, at surface locations to obtain the distribution of the gravity signal with spherical harmonic degree and, by implication, to the likely depth below the surface. The results provide estimates for the maximum likely depths of the primary component to the mass anomalies under 19 basins. We find that the maximum depths of the primary source of mascon gravity on the lunar nearside are deeper than the depths for those on the farside when South Pole–Aitken (SPA) is excluded. All basin mass anomalies on the lunar nearside are in the mantle. The maximum depth of the primary source of the mass anomalies is <80 km, with the exception of SPA, whose dominant mass signature lies at a maximum depth of >200 km beneath the surface. The upper 20 km under all basins is largely devoid of anomalies, reflecting predominantly mixing and relaxation associated with impact melt combined with ejecta fallback, as well as homogenization associated with post-basin formation impact bombardment. Except for SPA, all basin anomalies merge with the deep interior at ∼150 km or below, indicating the depth penetration of disruption of the density structure of the lunar interior associated with impact bombardment.
Diversity of Harvested Gastropods in Guang-Guang, Mati City, Davao Oriental, Philippines
Authors: Maynawang Imee S. , Macusi Edison D , Fadli Nur , Nallos Ivy M. 
Published: November 2023

Gastropods are a highly abundant group of mollusks in the marine environment. Marine gastropods primarily function as prey for other animals, grazers which help recycle nutrients and increase bioturbation activities in the marine ecosystem. Edible gastropods are significant to the economy of coastal communities. However, overexploitation leads to harming the population of marine gastropods. The study aimed to determine the diversity of gastropods harvested at Guang-guang, Mati City, Davao Oriental. It also assessed the abundance of the identified gastropods in the area. This study used purposive sampling to enroll gleaners (N = 30) who collected shells and monitored their gastropod harvest. The harvested gastropods were segregated, counted, and identified with the help of gleaners. A total of ten gastropod species were identified from the family of Strombidae, Conidae, Neritidae, Cypraeidae, and Turbinidae. The most abundant group after harvest was Canarium urceus, with a relative abundance of 67%, followed by Ilyanassa obsoleta, with 22%. However, the least harvested species was Nerita, with a relative abundance of 0.18%. The findings revealed that the harvested gastropods in Guang-guang have a diversity index of 0.99, indicating a low diversity of gastropods in the area. This low diversity could mean the area experienced overexploitation through time as gleaners have heavily harvested gastropods. With that, it is highly recommended that conservation should be prioritized to preserve the seashells.
SWEDISH ABDOMINAL MASSAGE SEBAGAI TERAPI KOMPLEMENTER UNTUK MENJAGA POLA ELIMINASI DEFEKASI DI ICU RSUD SUKOHARJO
Authors: Novitasari Cika , Husain Fida , Ika Yohana , Sulistyo Endar 
Published: November 2023

Pendahuluan: Konstipasi atau sembelit pada pasien dengan keadaana kritis didefinisikan yaitu tidak bisa buang air besar selama minimal 3-4 hari perawatan di ICU, yang dapat disebabkan salahsatunya oleh penurunan motilitas gastrointestinal. Ada dua cara untuk mengobati kostipasi: secara farmakologis dengan obat pencahar, dan secara non farmakologis dengan meningkatkan konsumsi serat dan cairan. Selain dari asupan makanan salah satu tindakan yang dapat membantu mencegah dan mengatasi konstipasi adalah dengan pemijatan pada area perut tepatnya pada area colon yang disebut dengan abdominal massage Tujuan: untuk mengetahui ada tidaknya pengaruh dari swedish abdominal massage terhadap keteraturan pola eliminasi defekasi. Metode: : jenis penelitian ini adalah deskriptif dengan studi kasus. Penerapan dilakukan pada 2 pasien yang dipilih dengan metode purposive sampling dengan kriteria inklusi dan ekslusi. Tindakan swedish abdominal massage ini dilakukan selama 15 menit sebanyak 1x/hari selama 3 hari. Instrumen penelitian ini menggunakan SOP swedish abdominal massage, lembar observasi dan informed consent. Penelitian ini sudah melalui uji etik dengan nomor 081/V/AUEC/2023. Hasil: dari hasil observasi yang dilakukan selama 3 hari pada 2 responden Tn. G dan Tn. S menunjukkan responden bisa BAB mulai hari ke 2 dan 3 yanga artinya terjadi perbaikan pola eliminasi defekasi pada 2 responden. Kesimpulan: dari penelitian ini swedish abdominal massage merupakan salah satu terapi pemijatan sederhana yang mampu membantu menjaga pola eliminasi defekasi agar teratur