bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical controls and regional pattern similarities of precipitation and flow duration curves using the three‐parameter gamma distribution
Authors: Zhou Yu , Zhang Yu‐Jia 
Published: February 2024

AbstractThe flow duration curve (FDC) is the cumulative distribution function, which represents the relationship between the frequency and magnitude of streamflow, and the precipitation duration curves (PDC) follows the same principle. Nowadays, the correlation between the shape of PDC and FDCs, their respective physical control factors including human activities, and their fitting conditions in unmeasured catchments across China have not been fully understood. In this paper, daily precipitation and streamflow data with 30 years records from 224 hydrological stations in the middle and lower Yangtze River basin were chosen to fit PDC and FDCs through gamma distribution. Framework was proposed for modelling FDCs to analyse the relationship, similarity, regional patterns and response mechanism of fitting parameters between PDC and FDCs, dividing the streamflow time series into fast and base flow and stations into three categories in consideration of human activities to attribute the shapes of PDC and FDCs to catchment meteorological and geographical characteristics and physical processes under natural conditions. Results indicate that the parameters of PDC and certain FDCs (TFDC, FFDC, SFDC) share similar spatial patterns but vary for the different duration and interactions of the processes. The climate and catchment characteristics such as extreme properties of precipitation, base flow index (BFI), Pmax*αp and concentration ratio index (CIM) will influence the shape of PDC and FDCs. The relationship between BFI and SFDC/TFDC can be better reflected in “Regulated watersheds”, while CIM/Pmax*αp and PDC/FFDC in “watersheds in the mainstream” are more related. This paper provides a deeper understanding and more accurate way of the application of these parameters in describing and predicting hydrological processes and estimation of PDC and FDCs in unmeasured catchments, and can be applied to more future research about processes based on catchment rainfall‐runoff responses and physical controls.
Rental market structure and housing dynamics: An interacted panel VAR investigation
Authors: Rubaszek Michal , Stenvall David , Uddin Gazi Salah 
Published: February 2024

AbstractThis article uses the interacted panel VAR method to analyse how institutional factors related to the structure of the housing market explain cross‐country heterogeneity in responses to macroeconomic shocks. While the previous literature focused on the stabilizing role of the mortgage market, we argue that housing tenure structure also plays an important role. In the baseline, we use data for nine OECD members to investigate how the size and regulations of the rental market affect the response of the housing market to interest rate shocks. As a reference, we also conduct a similar analysis with the mortgage market structure as the institutional factor. We find that both the rental market size and maximum loan‐to‐value ratios are important in explaining heterogeneity of housing market responses to macroeconomic shocks.
Atezolizumab Plus Bevacizumab Versus Lenvatinib for Hepatocellular Carcinoma: A Systematic Review and Meta‐Analysis
Authors: Lu Jinpeng , Lin Xinyi , Teng Haiwen , Zheng Yansong 
Published: February 2024

AbstractHepatocellular carcinoma (HCC) is often diagnosed in advanced stages. Following sorafenib, lenvatinib (LENV) has been approved as a first‐line treatment option for unresectable HCC. In the past few years, at least 9 large‐scale cohort studies have examined the efficacy and safety of LENV compared to atezolizumab plus bevacizumab (ATE/BEV) in unresectable HCC, but there is currently no direct meta‐analysis conducted for a comprehensive consolidation. To provide the most updated meta‐analysis of the clinical efficacy and safety of ATE/BEV versus LENV for patients with unresectable HCC. Our studies comparing the efficacy and safety of ATE/BEV and LENV in unresectable HCC were systematically searched in PubMed, Embase, and Web of Science from inception to February 2023. Outcomes measured were overall survival (OS), progression‐free survival (PFS), mortality, complete response (CR), partial response (PR), objective response rate (ORR), disease control rate (DCR), progressive disease (PD), stable disease (SD), and adverse events (AEs). Seven eligible studies involving 4428 patients (1569 in the ATE/BEV group and 2859 in the LENV group) were included in the narrative synthesis. All baseline characteristics were similar between the 2 groups except for Child‐Pugh class B. Ultimately, our meta‐analysis showed that the LENV group had longer OS and PFS than the ATE/BEV group. Moreover, patients on LENV were more likely to achieve SD, whereas those on ATE/BEV were more likely to achieve PR.
Desensitization using pegaspargase in the era of commercially available Erwinia: A single‐institution report on efficacy, cost, and resource utilization
Authors: Feldman Kira , Aaronson Kathryn , Gu Tina , Ige Kelsey , Southworth Erica , Sanchez Lauren , Stieglitz Elliot 
Published: February 2024

AbstractBackgroundPegaspargase is a therapeutic enzyme that is utilized in treatment regimens targeting pediatric acute lymphoblastic leukemia. However, many patients experience hypersensitivity reactions, requiring discontinuation of the therapy. Historically, this necessitated switching to an alternative form of the drug, most commonly asparaginase Erwinia chrysanthemi; however, in recent years this was difficult due to drug shortages and eventually commercial discontinuation. We report here our experience performing pegaspargase desensitizations in patients with prior hypersensitivity reactions.ProcedurePatients with a clinical hypersensitivity reaction to pegaspargase were identified. When due for their next dose, patients were admitted to the pediatric intensive care unit, bone marrow transplant unit, or oncology unit, and underwent desensitization utilizing a rigorous premedication and multistep dilution‐based protocol. Serum asparaginase activity levels were drawn after desensitization to assess for therapeutic levels of enzyme activity.ResultsWe identified 11 patients who underwent a total of 33 desensitizations to pegaspargase and calaspargase pegol‐mknl. No patients experienced clinically significant hypersensitivity reactions necessitating stopping the infusion, nor administration of rescue medications. All serum asparaginase activity levels collected demonstrated enzyme activity levels above predefined therapeutic thresholds. Cost analysis revealed substantial savings when patients received asparaginase desensitization over the now commercially available asparaginase E. chrysanthemi (recombinant) rywn.ConclusionsPerforming desensitization to pegaspargase in the pediatric acute lymphoblastic leukemia population is feasible, safe, and effective. It is financially advantageous over available alternative approaches, and requires fewer injections and presentations to care.
Experiences of a peer group for people diagnosed with borderline personality disorder: A qualitative interview study
Authors: Dahlenburg Sophie C. , Bartsch Dianna R. , Giles Jessica A. , Koehne Kristy A. , O'Sullivan Judy 
Published: February 2024

AbstractThere is a notable lack of literature evaluating peer support for people with a diagnosis of borderline personality disorder (BPD). Peer‐led groups have been shown to positively impact outcomes related to empowerment, hope, and self‐efficacy beliefs for consumers diagnosed with serious mental illness and may also be a helpful option for those experiencing personality disorder symptoms. We outline the coproduction of a peer group for people with a lived experience of BPD and a qualitative analysis of feedback post‐group participation. Twenty‐two consumers participated in post‐group interviews and described their experiences of peer support. Interview transcripts were coded, and three main themes were identified: growth and change, connection and feeling understood, and creating safety. The findings suggested that participation in a coproduced peer support group for people with a diagnosis of BPD facilitated positive personal transformation as well as opportunities to develop connection through shared experiences in a safe environment grounded in mutuality. These themes were particularly powerful for participants because they countered previous experiences of not feeling safe, understood, or equal when seeking treatment. These findings support the acceptability of implementing a coproduced group for people diagnosed with BPD in a community mental health setting.
Influence of molecular orientation on the photodissociation process of LiH molecules
Authors: Yan Yan , Liu Hong‐Ru , Sheng Zhu‐Ying , Cui Peng‐Fei , Yu Jie , Chai Shuo 
Published: February 2024

AbstractRegulation of photodissociation dynamics of oriented LiH molecules in different dissociation channels is proposed based on time dependent quantum wave packet theory. The enhancement of molecular orientation on the photodissociation of LiH is obvious with our theoretical scheme. The results show that the molecular orientation in the ground state has a great effect on the angular distributions of wave packets. By using the proper laser pulses and controlling the polarization direction of the laser pulses, the enhancement of the photodissociation could be realized. After the molecular orientation, an optimal dissociation channel is observed with an improved dissociation probability. Compared with the results without molecular orientation, the maximal dissociation probability is increased by 8.1% in the indirect dissociation channel and 30.7% in the direct dissociation channel. The enhancement effect is more obvious in the direct dissociation channel, which provides a possible method to manipulate the dissociation of LiH molecules experimentally. Additionally, the photodissociation process of LiH also relies on the electric intensity and delay time of two pump pulses.
Experimental characterization of a cost‐competitive tailor‐made HPFRC mix design for wide application in precast girder of roadway bridges
Authors: Ruiz Rafael , Chozas‐Ligero Valle , Todisco Leonardo , Jimenez‐Vicaria J. David , Corres Hugo 
Published: February 2024

AbstractThis paper presents a comprehensive study on the development of a cost‐effective, high‐performance fiber reinforced concrete (HPFRC) for the construction of a 60 m‐span U‐girder roadway bridge without stirrups in the webs, meeting the design requirements of fck ≥ 100 MPa and the post‐cracking flexural strength fR3k ≈ 8–10 MPa. The main objective of this research is to develop a F5 workability class HPFRC that meets the specified design criteria without exceeding 2.5–3.0 times the cost of a C70/85. To achieve this goal, the concrete mix was obtained using 500 kg/m3 of cement and 50 kg/m3 of silica fume. This mix was investigated with nine different combinations of fibers and fiber contents, resulting that 80 kg/m3 of 4D‐fibers (lf = 60 mm) provided the optimal fR3k without compromising workability and cost. Subsequently, an extensive experimental campaign was conducted to cast the U‐girder following the conventional casting techniques involving casting prismatic samples, L‐shaped and rectangular‐shaped panels to represent different parts of the U‐girder. Innovative techniques were used to study the effect of different waiting times between concrete pours. Results from the testing of the prismatic specimens evidenced the need of stitching by means of a poker vibrator planes between successive concrete layers. Furthermore, the study of the panels evidenced that a waiting time of 90 min allows the HPFRC to achieve enough bending and compressive strength to bear internal vibration of the element without liquefying and, at the same time, avoiding cold joints. The results confirm the applicability of the developed HPFRC for the structural element under study following conventional casting techniques.
Spontaneous resorption of a C7–T1 intervertebral disc extrusion in a Cavalier King Charles spaniel confirmed via low‐field MRI
Authors: du Toit Michelle , Alisauskaite Neringa 
Published: February 2024

AbstractA 4‐year‐old, male, neutered Cavalier King Charles spaniel was referred to the neurology service with a 10‐day history of cervical hyperaesthesia. A low‐field magnetic resonance imaging scan of the cervical spine identified a large C7–T1 intervertebral disc extrusion, resulting in severe spinal cord compression. The patient was treated with conservative therapy (exercise restriction and analgesia for 4 weeks). Repeat magnetic resonance imaging of the cervical spine was performed 4 months after initial presentation, and identified spontaneous resorption of the extruded C7–T1 disc material. There are very few documented cases of spontaneously resorbed cervical intervertebral disc extrusions in canine patients following successful conservative therapy. To the authors’ knowledge, this is the first report of spontaneous resorption of an intervertebral disc extrusion at an unusual C7–T1 location confirmed via follow‐up low‐field magnetic resonance imaging following conservative therapy.
Sectorial Mertens and Mirsky formulae for imaginary quadratic number fields
Authors: Parkkonen Jouni , Paulin Frédéric 
Published: February 2024

AbstractWe extend formulae of Mertens and Mirsky on the asymptotic behaviour of the usual Euler function to the Euler functions of principal rings of integers of imaginary quadratic number fields, giving versions in angular sectors and with congruences.
Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes
Authors: Frühbeck Gema , Gómez-Ambrosi Javier , Ramírez Beatriz , Becerril Sara , Rodríguez Amaia , Mentxaka Amaia , Valentí Víctor , Moncada Rafael , Reina Gabriel , Baixauli Jorge , Casado Marcos , Silva Camilo , Escalada Javier , Catalán Victoria 
Published: February 2024

Abstract
Background
Obesity-associated dysfunctional intestinal permeability contributes to systemic chronic inflammation leading to the development of metabolic diseases. The inflammasomes constitute essential components in the regulation of intestinal homeostasis. We aimed to determine the impact of the inflammasomes in the regulation of gut barrier dysfunction and metabolic inflammation in the context of obesity and type 2 diabetes (T2D).

Methods
Blood samples obtained from 80 volunteers (n = 20 normal weight, n = 21 OB without T2D, n = 39 OB with T2D) and a subgroup of jejunum samples were used in a case–control study. Circulating levels of intestinal damage markers and expression levels of inflammasomes as well as their main effectors (IL-1β and IL-18) and key inflammation-related genes were analyzed. The impact of inflammation-related factors, different metabolites and Akkermansia muciniphila in the regulation of inflammasomes and intestinal integrity genes was evaluated. The effect of blocking NLRP6 by using siRNA in inflammation was also studied.

Results
Increased circulating levels (P < 0.01) of the intestinal damage markers endotoxin, LBP, and zonulin in patients with obesity decreased (P < 0.05) after weight loss. Patients with obesity and T2D exhibited decreased (P < 0.05) jejunum gene expression levels of NLRP6 and its main effector IL18 together with increased (P < 0.05) mRNA levels of inflammatory markers. We further showed that while NLRP6 was primarily localized in goblet cells, NLRP3 was localized in the intestinal epithelial cells. Additionally, decreased (P < 0.05) mRNA levels of Nlrp1, Nlrp3 and Nlrp6 in the small intestinal tract obtained from rats with diet-induced obesity were found. NLRP6 expression was regulated by taurine, parthenolide and A. muciniphila in the human enterocyte cell line CCL-241. Finally, a significant decrease (P < 0.01) in the expression and release of MUC2 after the knockdown of NLRP6 was observed.

Conclusions
The increased levels of intestinal damage markers together with the downregulation of NLRP6 and IL18 in the jejunum in obesity-associated T2D suggest a defective inflammasome sensing, driving to an impaired epithelial intestinal barrier that may regulate the progression of multiple obesity-associated comorbidities.
LRP10 and α-synuclein transmission in Lewy body diseases
Authors: Carreras Mascaro Ana , Grochowska Martyna M. , Boumeester Valerie , Dits Natasja F. J. , Bilgiҫ Ece Naz , Breedveld Guido J. , Vergouw Leonie , de Jong Frank Jan , van Royen Martin E. , Bonifati Vincenzo , Mandemakers Wim 
Published: February 2024

AbstractAutosomal dominant variants in LRP10 have been identified in patients with Lewy body diseases (LBDs), including Parkinson’s disease (PD), Parkinson’s disease-dementia (PDD), and dementia with Lewy bodies (DLB). Nevertheless, there is little mechanistic insight into the role of LRP10 in disease pathogenesis. In the brains of control individuals, LRP10 is typically expressed in non-neuronal cells like astrocytes and neurovasculature, but in idiopathic and genetic cases of PD, PDD, and DLB, it is also present in α-synuclein-positive neuronal Lewy bodies. These observations raise the questions of what leads to the accumulation of LRP10 in Lewy bodies and whether a possible interaction between LRP10 and α-synuclein plays a role in disease pathogenesis. Here, we demonstrate that wild-type LRP10 is secreted via extracellular vesicles (EVs) and can be internalised via clathrin-dependent endocytosis. Additionally, we show that LRP10 secretion is highly sensitive to autophagy inhibition, which induces the formation of atypical LRP10 vesicular structures in neurons in human-induced pluripotent stem cells (iPSC)-derived brain organoids. Furthermore, we show that LRP10 overexpression leads to a strong induction of monomeric α-synuclein secretion, together with time-dependent, stress-sensitive changes in intracellular α-synuclein levels. Interestingly, patient-derived astrocytes carrying the c.1424 + 5G > A LRP10 variant secrete aberrant high-molecular-weight species of LRP10 in EV-free media fractions. Finally, we show that this truncated patient-derived LRP10 protein species (LRP10splice) binds to wild-type LRP10, reduces LRP10 wild-type levels, and antagonises the effect of LRP10 on α-synuclein levels and distribution. Together, this work provides initial evidence for a possible functional role of LRP10 in LBDs by modulating intra- and extracellular α-synuclein levels, and pathogenic mechanisms linked to the disease-associated c.1424 + 5G > A LRP10 variant, pointing towards potentially important disease mechanisms in LBDs.
Graphical abstract
A KAM Approach to the Inviscid Limit for the 2D Navier–Stokes Equations
Authors: Franzoi Luca , Montalto Riccardo 
Published: February 2024

AbstractIn this paper, we investigate the inviscid limit $$\nu \rightarrow 0$$

ν
→
0

for time-quasi-periodic solutions of the incompressible Navier–Stokes equations on the two-dimensional torus $${\mathbb {T}}^2$$

T

2

, with a small time-quasi-periodic external force. More precisely, we construct solutions of the forced Navier–Stokes equation, bifurcating from a given time quasi-periodic solution of the incompressible Euler equations and admitting vanishing viscosity limit to the latter, uniformly for all times and independently of the size of the external perturbation. Our proof is based on the construction of an approximate solution, up to an error of order $$O(\nu ^2)$$

O
(

ν
2

)

and on a fixed point argument starting with this new approximate solution. A fundamental step is to prove the invertibility of the linearized Navier–Stokes operator at a quasi-periodic solution of the Euler equation, with smallness conditions and estimates which are uniform with respect to the viscosity parameter. To the best of our knowledge, this is the first positive result for the inviscid limit problem that is global and uniform in time and it is the first KAM result in the framework of the singular limit problems.
Examining temporal trends in psychological distress and the co-occurrence of common substance use in a population-based sample of grade 7–12 students from 2013 to 2019
Authors: Halladay J. , Sunderland M. , Chapman C. , Repchuck R. , Georgiades K. , Boak A. , Hamilton H. A. , Slade T. 
Published: February 2024

Abstract
Purpose
Characterizing trends and correlates of adolescent psychological distress is important due to observed global increases over the last 20 years. Substance use is a commonly discussed correlate, though we lack an understanding about how co-occurrence of these concerns has been changing over time.

Methods
Data came from repeated, representative, cross-sectional surveys of grade 7–12 students across Ontario, Canada conducted biennially from 2013 to 2019. Poisson regression with robust standard errors was used to examine changes in the joint association between psychological distress (operationalized as Kessler-6 [K6] scores ≥ 13) and substance use over time. Weighted prevalence ratios (PR) and their 99% confidence intervals were estimated, where p < 0.01 denotes statistical significance.

Results
The prevalence of psychological distress doubled between 2013 and 2019, with adjusted increases of about 1.2 times each survey year. This biennial increase did not differ based on sex, perceived social standing, school level, or any substance use. Students using substances consistently reported a higher prevalence of psychological distress (between 1.2 times and 2.7 times higher). There were similarly no differential temporal trends based on substance use for very high distress (K6 ≥ 19) or K6 items explored individually.

Conclusion
Psychological distress steeply increased among adolescents and substance use remains important to assess and address alongside distress. However, the magnitude of temporal increases appears to be similar for adolescents reporting and not reporting substance use.
Directed energy deposition + mechanical interlayer deformation additive manufacturing: a state-of-the-art literature review
Authors: Farias Francisco Werley Cipriano , dos Santos Telmo Jorge Gomes , Oliveira João Pedro 
Published: February 2024

AbstractDirected energy deposition (DED) additive manufacturing systems have been developed and optimized for typical engineering materials and operational requirements. However, parts fabricated via DED often demonstrate a diminished material response, encompassing inferior mechanical properties and heat treatment outcomes compared to traditionally manufactured components (e.g., wrought and cast materials). As a result, parts produced by DED fail to meet stringent specifications and industry requirements, such as those in the nuclear, oil and gas, and aeronautics sectors, potentially limiting the industrial scalability of DED processes. To address these challenges, systems integrating DED with interlayer (cold or hot) mechanical deformation (e.g., rolling and hammering/peening, forging) have been developed. These systems refine the microstructure, mitigate the typical crystallographic texture through static and/or dynamic recrystallization, and enhance mechanical properties and heat treatment responses without altering material specifications. In this regard, the present state-of-the-art review reports the DED + interlayer mechanical deformation systems and their variants, and their potential and limitations, providing a critical analysis to support the development and adaptation of this technology to overcome the process and material limitations that currently prevent the large-scale industrial adoption of DED processes. Furthermore, a detailed description of the grain size refinement mechanisms induced by interlayer mechanical deformation and their respective effects on the mechanical properties of commonly used 3D-printed engineering alloys (e.g., Ti-6Al-4V, Inconel 718, various low-alloy steels, AISI 316L stainless steel, and Al-based series 2xxx) is comprehensively analyzed.