bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute neuro-biochemical changes induced by nitrogen-tungsten co-doped titanium dioxide nanoparticles
Authors: Farooqi Hafiz Muhammad Umer , Lee Jooho , Lee Cheong-Ah , Im Seung-Uk , Farooqi Muhammad Awais , Gul Tasbiha , Siddiqui Ghayas Uddin , Paeng Dong-Guk 
Published: November 2023

AbstractNitrogen-tungsten co-doped titanium dioxide nanoparticles (W-N-doped TiO2 NPs) are employed for the photocatalytic degradation of environmental pollutants. However, the potential impact of these nanoparticles on the central nervous system remains a subject of concern. This study aimed to evaluate the effects of W-N-doped TiO2 NPs on neurophysiological and biochemical parameters of healthy rat brains, including behavioral monitoring, electroencephalogram analysis, and oxidative stress markers quantification. Intraperitoneal administration of W-N-doped TiO2 NPs to rats revealed abnormal brain electrical activity and an altered sense of balance in the treated rats. The ability of W-N-doped TiO2 NPs to cross the blood–brain barrier and accumulate in the brain leads to oxidative stress damage, supported by the elevated levels of reactive oxygen species (ROS), nitrite concentration, and malondialdehyde levels. Additionally, exposure to W-N-doped TiO2 NPs significantly reduced the antioxidant enzyme levels, such as catalase and superoxide dismutase, impacting a significant decrease in dopamine and acetylcholinesterase within the rat neural tissue. Furthermore, the inflammatory biomarker tumor necrosis factor-alpha and 8-hydroxy 2-deoxyguanosine significantly increased in response to W-N-doped TiO2 NPs. The findings revealed the adverse effects of W-N-doped TiO2 NPs on the electrical activity of rat brains and the altered concentration of various neuro-biomarkers, highlighting their potential neurotoxicity.
Understanding the mechanisms of ventilator-induced lung injury using animal models
Authors: Silva Pedro Leme , Scharffenberg Martin , Rocco Patricia Rieken Macedo 
Published: November 2023

AbstractMechanical ventilation is a life-saving therapy in several clinical situations, promoting gas exchange and providing rest to the respiratory muscles. However, mechanical ventilation may cause hemodynamic instability and pulmonary structural damage, which is known as ventilator-induced lung injury (VILI). The four main injury mechanisms associated with VILI are as follows: barotrauma/volutrauma caused by overstretching the lung tissues; atelectrauma, caused by repeated opening and closing of the alveoli resulting in shear stress; and biotrauma, the resulting biological response to tissue damage, which leads to lung and multi-organ failure. This narrative review elucidates the mechanisms underlying the pathogenesis, progression, and resolution of VILI and discusses the strategies that can mitigate VILI. Different static variables (peak, plateau, and driving pressures, positive end-expiratory pressure, and tidal volume) and dynamic variables (respiratory rate, airflow amplitude, and inspiratory time fraction) can contribute to VILI. Moreover, the potential for lung injury depends on tissue vulnerability, mechanical power (energy applied per unit of time), and the duration of that exposure. According to the current evidence based on models of acute respiratory distress syndrome and VILI, the following strategies are proposed to provide lung protection: keep the lungs partially collapsed (SaO2 > 88%), avoid opening and closing of collapsed alveoli, and gently ventilate aerated regions while keeping collapsed and consolidated areas at rest. Additional mechanisms, such as subject-ventilator asynchrony, cumulative power, and intensity, as well as the damaging threshold (stress–strain level at which tidal damage is initiated), are under experimental investigation and may enhance the understanding of VILI.
Heart failure drug classes and 30-day unplanned hospital readmission among patients with heart failure in Ethiopia
Authors: Ayenew Birhanu , Kumar Prem , Hussein Adem , Gashaw Yegoraw , Girma Mitaw , Ayalew Abdulmelik , Tadesse Beza 
Published: November 2023

Abstract
Background
Drug therapy is a crucial aspect of heart failure management and has been shown to reduce morbidity and mortality in heart failure patients. However, the comparative effects of these drug classes on readmission rates have not been well studied. Therefore, the aim of this study was to examine the association between different classes of heart failure drugs and 30-day readmission rates in patients with heart failure.

Method
A multicenter, hospital-based retrospective cohort design was employed and 572 randomly selected patients with heart failure were included. Data were entered in Epi-data version 4.6 and analyzed with STATA version 17. Kaplan-Meier and log-rank tests were used to estimate and compare survival time. A Cox proportional hazard model was utilized, employing both bi-variable and multi-variable analyses, to examine the effect of predictors on the timing of unplanned hospital readmissions. The strength of the association was assessed using an adjusted hazard ratio (aHR), and statistical significance was declared for p-values < 0.05 and a 95% confidence interval (CI).

Results
In this study, a total of 151 (26.40%) heart failure patients were readmitted within 30 days of discharge. In the multivariate cox proportional hazards analysis being an age (> 65 year) (AHR: 2.34, 95%CI: 1.63, 3.37), rural in residency (AHR: 1.85, 95%CI: 1.07, 3.20), hospital stays > 7 Days (AHR: 3.68, 95%CI: 2.51,5.39), discharge with Diuretics (AHR: 2.37, 95%CI: 1.45, 3.86), and discharge with Beta-Blocker (AHR: 0.48, 95%CI: 0 0.34, 0.69) were identified as independent predictors of unplanned hospital readmission.

Conclusion
Elderly patients, being in rural areas, longer hospital stays, and discharges of patients on diuretics and not on beta-blockers were independent predictors of unplanned hospital readmission. Therefore, working on these factors will help to reduce the hazard of unplanned hospital readmissions, improve patient outcomes, and increase the efficiency of heart failure management.
Reducing the risk of criminal exploitation using multi-systemic therapy (the RESET Study): study protocol for a feasibility study and process evaluation
Authors: Hayden N. K. , Flynn S. , Blumenfeld F. , Hastings R. P. , Gray K. M. , Cullen S. , Cullen M. A. , Langdon P. E. 
Published: November 2023

Abstract
Background
Child criminal exploitation is a form of child abuse that poses a serious risk to the welfare, safety, and wellbeing of young people. Multisystemic therapy (MST) is an intensive family and community-based intervention for young people with anti-social behavioral problems, many of whom will be at risk of criminal exploitation. This protocol describes a pilot feasibility study and process evaluation, designed to examine MST for children at risk of criminal exploitation.

Methods
This pilot feasibility study and process evaluation involves two phases with associated subphases: phase 1.1 involved the collaborative refinement of the logic model adapting MST for children at risk of criminal exploitation; phase 1.2 involved pre-pilot interviews with MST therapists, families, and young people; phase 2.1 is a pilot modeling study of MST for children at risk of criminal exploitation, and; Phase 2.2 is a process evaluation that will involve interviewing stakeholders, MST therapists and employees, families, and young people. The dataset for the process evaluation will include questionnaires completed by parents and young people at baseline, mid-treatment, end of treatment, and 6 months after treatment. We will supplement these data with participant-level data linkage from MST sites and services.

Results
Accrual to the pilot stage of this project opened on 6th August 2021 and is due to close on 31st May 2022. We aim to publish the results of this feasibility study and process evaluation in 2023.

Conclusions
The results of this feasibility study and process evaluation will inform the decision as to whether it is advisable to progress to a pilot clinical trial of MST for children at risk of criminal exploitation.

Trial registration
Trial registration: ISRCTN registry, ISRCTN16164816 on 25th January 2021—https://doi.org/10.1186/ISRCTN16164816.
Condylar volume and positional changes following a bilateral sagittal split ramus osteotomy in skeletal class II and III malocclusions
Authors: Park Chulyoung , Kim Hyejin , Ryu Jaeyoung , Jung Seunggon , Park Hong-Ju , Oh Hee-Kyun , Kook Min-Suk 
Published: November 2023

Abstract
Background
Mandibular condyle remodeling and displacement are post-orthognathic surgery concerns that can potentially lead to occlusal issues after bilateral sagittal split ramus osteotomy. This retrospective study examined the relationship between condylar volume changes and position alterations after surgery in patients with skeletal class II and III malocclusions using cone-beam CT.

Methods
The study included 16 patients (6 with Class II malocclusion, 10 with Class III malocclusion) who underwent bilateral sagittal split ramus osteotomy at Chonnam National University Hospital. Cone-beam CT data were collected at three specific time points: before surgery, immediately after surgery, and approximately 6 months post-surgery. Mandibular movement was measured using InVivoDental 5.4.6. ITK-SNAP 3.8.0 was used to assessed condylar volume changes post-surgery. Condyle positions were evaluated in four parts with RadiAnt DICOM Viewer 4.6.9. Statistical analyses were performed using the SPSS version 23.

Results
Considering both Class II and III malocclusion, a 2.91% volume reduction was noted immediately and at 6 months after surgery. Both Class II and III cases demonstrated a decrease in superior joint space by -0.59 mm and medial joint space by -1.09 mm. No significant correlation was found between this process and condylar volume change.

Conclusions
The mandibular condyle volume decreased, and superior-medial movement of the condyle was detected in patients with Class II and III malocclusion immediately and at 6 months after surgery with no volume-position correlation.
Effects of mepiquat chloride and plant population density on leaf photosynthesis and carbohydrate metabolism in upland cotton
Authors: Luo Haihua , Zhang Zhengxian , Wu Jianfei , Wu Zhenjiang , Wen Tianwang , Tang Feiyu 
Published: November 2023

Abstract
Background
Mepiquat chloride (MC) application and plant population density (PPD) increasing are required for modern cotton production. However, their interactive effects on leaf physiology and carbohydrate metabolism remain obscure. This study aimed to examine whether and how MC and PPD affect the leaf morpho-physiological characteristics, and thus final cotton yield. PPD of three levels (D1: 2.25 plants·m−2, D2: 4.5 plants·m−2, and D3: 6.75 plants·m−2) and MC dosage of two levels (MC0: 0 g·ha−2, MC1: 82.5 g·ha−2) were combined to create six treatments. The dynamics of nonstructual carbohydrate concentration, carbon metabolism-related enzyme activity, and photosynthetic attributes in cotton leaves were examined during reproductive growth in 2019 and 2020.

Results
Among six treatments, the high PPD of 6.75 plants·m−2 combined with MC application (MC1D3) exhibited the greatest seed cotton yield and biological yield. The sucrose, hexose, starch, and total nonstructural carbohydrate (TNC) concentrations peaked at the first flowering (FF) stage and then declined to a minimum at the first boll opening (FBO) stage. Compared with other treatments, MC1D3 improved starch and TNC concentration by 5.4% ~ 88.4%, 7.8% ~ 52.0% in 2019, and by 14.6% ~ 55.9%, 13.5% ~ 39.7% in 2020 at the FF stage, respectively. Additionally, MC1D3 produced higher transformation rates of starch and TNC from the FF to FBO stages, indicating greater carbon production and utilization efficiency. MC1D3 displayed the maximal specific leaf weight (SLW) at the FBO stage, and the highest chlorophyll a (Chl a), Chl b, and Chl a + b concentration at the mid-late growth phase in both years. The Rubisco activity with MC1D3 was 2.6% ~ 53.2% higher at the flowering and boll setting stages in both years, and 2.4% ~ 52.7% higher at the FBO stage in 2020 than those in other treatments. These results provided a explanation of higher leaf senescence-resistant ability in MC1D3.

Conclusion
Increasing PPD coupled with MC application improves cotton yield by enhancing leaf carbohydrate production and utilization efficiency and delaying leaf senescence.
Feasibility study of assessing cotton fiber maturity from near infrared hyperspectral imaging technique
Authors: Liu Yongliang , Tao Feifei , Yao Haibo , Kincaid Russell 
Published: November 2023

Abstract
Background
Fiber maturity is a key cotton quality property, and its variability in a sample impacts fiber processing and dyeing performance. Currently, the maturity is determined by using established protocols in laboratories under a controlled environment. There is an increasing need to measure fiber maturity using low-cost (in general less than $20 000) and small portable systems. In this study, a laboratory feasibility was performed to assess the ability of the shortwave infrared hyperspectral imaging (SWIR HSI) technique for determining the conditioned fiber maturity, and as a comparison, a bench-top commercial and expensive (in general greater than $60 000) near infrared (NIR) instrument was used.

Results
Although SWIR HSI and NIR represent different measurement technologies, consistent spectral characteristics were observed between the two instruments when they were used to measure the maturity of the locule fiber samples in seed cotton and of the well-defined fiber samples, respectively. Partial least squares (PLS) models were established using different spectral preprocessing parameters to predict fiber maturity. The high prediction precision was observed by a lower root mean square error of prediction (RMSEP) (< 0.046), higher Rp2 (> 0.518), and greater percentage (97.0%) of samples within the 95% agreement range in the entire NIR region (1 000∼2 500 nm) without the moisture band at 1 940 nm.

Conclusion
SWIR HSI has a good potential for assessing cotton fiber maturity in a laboratory environment.
Validation of arrhythmogenic right ventricular cardiomyopathy risk calculator for sudden cardiac death: a systematic review
Authors: Rashid Sarim , Pahwani Ritesh , Raj Sahil , Khan Hafiz Ahmed Raza , Nadeem Saffa , Ghani Muhammad Usman , Basit Jawad , Mehmoodi Amin , Malik Jahanzeb 
Published: November 2023

AbstractIn the context of ARVC, a systematic review of the validation of the ARVC risk score can provide insights into the accuracy and reliability of this score in identifying patients at high risk of ARVC. Digital databases were searched to identify the relevant studies using Medical Subject Headings (MeSH). A total of 8 studies were included in this systematic review. A total of 8 studies were included in this review. The review found that the sensitivity of the ARVC risk scores ranged from 80 to 95%, and the specificity ranged from 31 to 79%. The PPV was 55%, and the NPV was 88%. The ARVC score provided a C-index for a 5-year VA risk prediction of 0.84 [95% CI (0.74–0.93)] and a Harrell C-index of 0.70 (95% CI 0.65–0.75). The calibration slope was 1.01 (95% CI 0.99–1.03). ARVC score demonstrated a significant event 5-year threshold between 15 and 20% and the classical ARVC 5-years/freedom-from-VA rate was 0.76(0.66–0.89) and the non-classical form 5-years/freedom-from-VA rate was 0.58 (0.43–0.78). In conclusion, the validation of ARVC risk scores is an essential step toward improving the accuracy of ARVC diagnosis and risk stratification. Further studies are needed to establish the accuracy and reliability of ARVC risk scores and to address the limitations of the current evidence.
Propolis from different Brazilian stingless bee species: phenolic composition and antimicrobial activity
Authors: Rocha Vitor Moreira , Portela Ricardo Wagner , Lacerda Luiz Eduardo , Sokolonski Ana Rita , de Souza Carolina Oliveira , dos Anjos Jeancarlo Pereira , Nascimento Renata Quartieri , Umsza-Guez Marcelo Andrés 
Published: November 2023

AbstractStingless bees (SLB) are insects bread many centuries ago by indigenous people and more than 500 species have already been described. Interest in SLB's propolis has grown as a way to value and preserve native bees, in addition to investigating/prospecting compounds with biological functionality (antimicrobial activity, antioxidant, etc.). The natural active compounds found in propolis come from different plant sources, and consequently, each propolis may show unique biological/pharmacological activity. There is still an important gap about the profile of chemical compounds, biological and pharmacological potential of propolis produced by SLBs. This work aimed to investigate the presence of phenolic and coumaric compounds (HPLC–DAD-FLD) and the antimicrobial activity (microdilution method) of propolis extracts from five different species of SLB reared in different places. The samples from Melipona quadrifasciata (82.05 mgGAEg−1) and one from, Frieseomelitta doederleini (56.22 mgGAEg−1) showed the highest concentrations of phenolic compounds. It was possible to identify in the propolis samples formononetin, kaempferol, gallic acid and coumarin. Resveratrol was detected in all samples, an unprecedent fact for SLB propolis. Candida albicans was susceptible to all tested extracts, while Escherichia coli was inhibited only by propolis from Melipona quadrifasciata; Enterococcus faecalis was inhibited by propolis from Plebeiadroryana., Melipona quadrifasciata and Frieseomelitta doederleini. It was verified that SLB propolis constitutes a source of different biocompounds, which varies according to the location where the bees are raised, and has mainly antifungal activity, generating possibilities of its use in different biotechnological products.
Graphical Abstract
Atrial fibrillation, electroconvulsive therapy, stroke risk, and anticoagulation
Authors: Kapadia Meera , Jagadish Pooja S. , Hutchinson Marcus , Lee Hong 
Published: November 2023

Abstract
Background
Electroconvulsive therapy (ECT) is a therapy used to treat refractory mental health conditions, ranging from depression to catatonia, and it has gained renewed prominence in practice and the literature of late. Given that ECT involves the application of direct current to the body, there exists a risk of a change in cardiac rhythm during therapy. When atrial fibrillation is induced, ECT carries a potential risk of stroke. These risks have not been previously analyzed or summarized in the literature to allow physicians to make educated decisions about periprocedural risk and anticoagulation needs.

Methods
To better describe this risk, the authors reviewed PubMed for articles that described the post-ECT cardioversion of AF to sinus rhythm, new development of AF post-ECT, and new stroke after either rhythm change.

Results
Included were 14 studies describing 19 unique patients. Most patients had no rhythm change during at least one of many ECT sessions. Five patients converted from AF to sinus rhythm during at least one session, while AF followed ECT in seventeen patients during at least one ECT session. Four patients experienced both ECT-related cardioversion from AF to sinus rhythm as well as conversion from sinus rhythm to AF. Although no patients with a rhythm change experienced a stroke, one unanticoagulated patient who remained in AF developed a stroke post-ECT.

Conclusions
Electroconvulsive therapy is demonstrated to be associated with rhythm changes—from atrial fibrillation to sinus rhythm as well as from sinus rhythm to atrial fibrillation. Thus, stroke risk during and after ECT remains a possibility. The anticoagulation of patients with AF who undergo ECT should be based on individual stroke risk factors, using validated stroke risk models, rather than prescribed routinely.
The moderating role of posttraumatic growth in secondary traumatic stress–burnout relationship: a sample of child psychiatrists from Turkey
Authors: Akdağ Berhan , Çelebi Seda Bozduman , İpekten Funda , Usluoğlu Feyruz , Nasıroğlu Serhat 
Published: November 2023

Abstract
Background
Secondary traumatization is a common occupational hazard for professionals working with distressed and traumatized people, especially children. If not properly managed, secondary traumatization can lead to symptoms similar to posttraumatic stress disorder. This condition is known as secondary traumatic stress (STS) and is linked to adverse mental health outcomes, such as burnout. Nevertheless, exposure to a traumatic event or its disturbing details can contribute to personal transformation, allowing an individual to move beyond pre-traumatic functioning and awareness. This process is called posttraumatic growth and is associated with positive mental health outcomes. The current study examined the relationship between STS and burnout and whether posttraumatic growth moderates this relationship in a sample of child psychiatrists.

Methods
An online questionnaire was designed and distributed to participants. A total of 59 child psychiatrists working in Turkey completed measures including the Copenhagen Burnout Inventory-work burnout subscale, the Posttraumatic Growth Inventory, and the Secondary Traumatic Stress Scale.

Results
While STS was positively related to burnout (r = 0.661, p < .001), posttraumatic growth moderated this relationship. In other words, the relationship between STS and burnout was weaker for child psychiatrists with higher posttraumatic growth.

Conclusions
Promoting posttraumatic growth may be a good way to reduce burnout among child psychiatrists. Individual or group supervision can promote posttraumatic growth by providing a supportive environment for child psychiatrists. Balancing workloads and creating time for self-care can also contribute to their growth.