bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐Step Cooperative Growth of High Reaction Kinetics Composite Homogeneous Core–Shell Heterostructure
Authors: Liu Hao , Chen Qi , Chen Haochang , Zhang Shunzhe , Wang Kaifeng , Chen Yujie , Liu Hezhou , Zhang Chongyin , Shi Lu , Li Hua 
Published: December 2023

AbstractReaction kinetics can be improved by the enhanced electrical contact between different components growing symbiotically. But so far, due to the necessity for material synthesis conditions match, the component structures of cooperative growth are similar, and the materials are of the same type. The collaborative growth of high‐reaction kinetics composite homogeneous core–shell heterostructure between various materials is innovatively proposed with different structures in one step. The NiCo‐LDH and PPy successfully symbiotically grow on activated carbon fiber fabric in one step. The open channel structure of the NiCo‐LDH nanosheets is preserved while PPy effectively wrapped around the NiCo‐LDH. The well‐defined nanostructure with abundant active sites and convenient ion diffusion paths is favorable for electrolyte entry into the entire nanoarrays. In addition, owing to the enhanced electronic interaction between different components through XPS analysis, the NiCo‐LDH@PPy electrode shows outstanding reaction kinetics and structural stability. The as‐synthesized NiCo‐LDH@PPy exhibited excellent super‐capacitive storage capabilities, robust capacitive activity, and good rate survival. Furthermore, an asymmetric supercapacitor (ASC) device made of NiCo‐LDH@PPy and activated carbon (AC) is able to maintain a long cycle life while achieving high power and energy densities.
Engineering Proteins for PEDOT Dispersions: A New Horizon for Highly Mixed Ionic‐Electronic Biocompatible Conducting Materials
Authors: Dominguez‐Alfaro Antonio , Casado Nerea , Fernandez Maxence , Garcia‐Esnaola Andrea , Calvo Javier , Mantione Daniele , Calvo Maria Reyes , Cortajarena Aitziber L. 
Published: December 2023

AbstractPoly (3,4‐ethylenedioxythiophene) (PEDOT) doped with polystyrene sulfonate (PSS) is the most used conducting polymer from energy to biomedical applications. Despite its exceptional properties, there is a need for developing new materials that can improve some of its inherent limitations, e.g., biocompatibility. In this context, doping PEDOT is propose with a robust recombinant protein with tunable properties, the consensus tetratricopeptide repeated protein (CTPR). The doping consists of an oxidative polymerization, where the PEDOT chains are stabilized by the negative charges of the CTPR protein. CTPR proteins are evaluated with three different lengths (3, 10, and 20 identical CTPR units) and optimized varied synthetic conditions. These findings revealed higher doping rate and oxidized state of the PEDOT chains when doped with the smallest scaffold (CTPR3). These PEDOT:CTPR hybrids possess ionic and electronic conductivity. Notably, PEDOT:CTPR3 displayed an electronic conductivity of 0.016 S cm−1, higher than any other reported protein‐doped PEDOT. This result places PEDOT:CTPR3 at the level of PEDOT‐biopolymer hybrids, and brings it closer in performance to PEDOT:PSS gold standard. Furthermore, PEDOT:CTPR3 dispersion is successfully optimized for inkjet printing, preserving its electroactivity properties after printing. This approach opens the door to the use of these novel hybrids for bioelectronics.
Breaking Osteoclast‐Acid Vicious Cycle to Rescue Osteoporosis via an Acid Responsive Organic Framework‐Based Neutralizing and Gene Editing Platform
Authors: Lin Wenzheng , Hu Sihan , Li Ke , Shi Yu , Pan Chun , Xu Zhuobin , Li Dandan , Wang Huihui , Li Bin , Chen Hao 
Published: December 2023

AbstractIn the osteoporotic microenvironment, the acidic microenvironment generated by excessive osteoclasts not only causes irreversible bone mineral dissolution, but also promotes reactive oxygen species (ROS) production to induce osteoblast senescence and excessive receptor activator of nuclear factor kappa‐B ligand (RANKL) production, which help to generate more osteoclasts. Hence, targeting the acidic microenvironment and RANKL production may break this vicious cycle to rescue osteoporosis. To achieve this, an acid‐responsive and neutralizing system with high in vivo gene editing capacity is developed by loading sodium bicarbonate (NaHCO3) and RANKL‐CRISPR/Cas9 (RC) plasmid in a metal–organic framework. This results showed ZIF8‐NaHCO3@Cas9 (ZNC) effective neutralized acidic microenvironment and inhibited ROS production . Surprisingly, nanoparticles loaded with NaHCO3 and plasmids show higher transfection efficiency in the acidic environments as compared to the ones loaded with plasmid only. Finally, micro‐CT proves complete reversal of bone volume in ovariectomized mice after ZNC injection into the bone remodeling site. Overall, the newly developed nanoparticles show strong effect in neutralizing the acidic microenvironment to achieve bone protection through promoting osteogenesis and inhibiting osteolysis in a bidirectional manner. This study provides new insights into the treatment of osteoporosis for biomedical and clinical therapies.
Nanotechnology Applications in Breast Cancer Immunotherapy
Authors: Wang Ruijie , Kumar Pramod , Reda Moataz , Wallstrum Alyssa G. , Crumrine Noah A. , Ngamcherdtrakul Worapol , Yantasee Wassana 
Published: December 2023

AbstractNext‐generation cancer treatments are expected not only to target cancer cells but also to simultaneously train immune cells to combat cancer while modulating the immune‐suppressive environment of tumors and hosts to ensure a robust and lasting response. Achieving this requires carriers that can codeliver multiple therapeutics to the right cancer and/or immune cells while ensuring patient safety. Nanotechnology holds great potential for addressing these challenges. This article highlights the recent advances in nanoimmunotherapeutic development, with a focus on breast cancer. While immune checkpoint inhibitors (ICIs) have achieved remarkable success and lead to cures in some cancers, their response rate in breast cancer is low. The poor response rate in solid tumors is often associated with the low infiltration of anti‐cancer T cells and an immunosuppressive tumor microenvironment (TME). To enhance anti‐cancer T‐cell responses, nanoparticles are employed to deliver ICIs, bispecific antibodies, cytokines, and agents that induce immunogenic cancer cell death (ICD). Additionally, nanoparticles are used to manipulate various components of the TME, such as immunosuppressive myeloid cells, macrophages, dendritic cells, and fibroblasts to improve T‐cell activities. Finally, this article discusses the outlook, challenges, and future directions of nanoimmunotherapeutics.
A noise blocking methodology for effective collaboration
Authors: Yang Yun‐Tai , Ye Hong‐Bao , Li Yi‐Shan , Jiau Hewijin Christine 
Published: December 2023

AbstractCollaboration relies on efficient communication among developers. Many development teams use instant messaging owing to its synchronous and real‐time nature. Despite the convenience provided by instant messaging, developers spend a great amount of time on handling information and task interruption. Consequently, productivity of developers and effectiveness of collaboration are declined. To address the issue, this work introduces an aggressive methodology of noise blocking. The methodology appropriately prioritizes messages based on collaboration requirements. A message which is not urgent for developers to collaborate with others is defined as noise, and such message is blocked to stop unnecessary interruption. To evaluate the proposed methodology, this work conducts experiments on datasets collected from real‐world projects. Then, a noise analysis tool—message analyzer for instant notification of information (MINI)—is implemented. The evaluation results show that noise hinders collaboration significantly because almost half of messages are noise. When MINI is applied, more than 80% of noise is identified, and at most 91.6% of time wasted in noise for the whole team is saved. The proposed noise blocking methodology shows promising results.
CircTAOK1 regulates high glucose induced inflammation, oxidative stress, ECM accumulation, and apoptosis in diabetic nephropathy via targeting miR‐142‐3p/SOX6 axis
Authors: Liu Shu‐yan , Wang Hong , Yang Bo , Hou Baohua , Sun Li‐sha , Pang Hui , Wang Hui‐hui , Fan Yan‐ping 
Published: December 2023

AbstractBackgroundDiabetic nephropathy (DN) is a complication caused by diabetes. Circular RNAs (circRNAs) are a kind of RNA with a closed circular structure, which has high stability and is involved in many disease‐related processes. The mechanism of circRNA TAO kinase 1 (circTAOK1) in the pathogenesis and development of DN is unclear.MethodsCircTAOK1, microRNA (miR)‐142‐3p, and sex‐determining region Y‐box transcription factor 6 (SOX6) mRNA levels were analyzed by real‐time quantitative polymerase chain reaction (RT‐qPCR). Cell counting kit‐8 (CCK8) and 5‐ethynyl‐2′‐deoxyuridine (EdU) assays were used to analyze cell proliferation. Cell cycle distribution was detected by flow cytometry. Western blot assay was performed to test B‐cell lymphoma 2 (Bcl‐2), Bcl‐2 associated X (Bax), cleaved‐caspase 3, and fibronectin (FN), collagen I (Col I), and collagen IV (Col IV) protein levels. ELISA assay was used to measure interleukin 1β (IL‐1β), interleukin 6 (IL‐6), and tumor necrosis factor (TNF‐α) levels. The reactive oxygen species (ROS) and malondialdehyde (MDA) levels and the superoxide dismutase (SOD) activity were assessed by the corresponding kits. And the correlation between miR‐142‐3p and circTAOK1 or SOX6 was confirmed by dual luciferase reporter assay, RNA immunoprecipitation assay and RNA pull down assay.ResultsCircTAOK1 and SOX6 expression levels were up‐regulated, while miR‐142‐3p expression was down‐regulated in DN serum and HG‐treated HK‐2 cells. Knockdown of circTAOK1 could inhibit cell injury of HG‐induced HK‐2 cells. The inhibitory effect of circTAOK1 knockdown on HG‐induced HK‐2 cell injury was restored by miR‐142‐3p downregulation. CircTAOK1 acted as a sponge for miR‐142‐3p, and SOX6 was targeted by miR‐142‐3p. The overexpression of SOX6 could recover the effect of miR‐142‐3p overexpression on HG‐induced HK‐2 cell injury. CircTAOK1 regulated the expression of SOX6 by targeting miR‐142‐3p.ConclusionCircTAOK1 knockdown inhibited HG‐induced HK‐2 cell damage in DN by the miR‐142‐3p/SOX6 axis.
Effects of CuSO4 on hepatic mitochondrial function, biogenesis and dynamics in mice
Authors: Wang Yihan , Zhu Yanqiu , Cui Hengmin , Deng Huidan , Zuo Zhicai , Fang Jing , Guo Hongrui 
Published: December 2023

AbstractCopper is an essential trace element for animal. Excessive intake of copper will cause a large accumulation of copper in the body, especially in the liver, and induce hepatotoxicity, however, there are few studies on the effects of copper on hepatic mitochondrial biogenesis and mitochondrial dynamics. In this study, mice were treated with different doses of CuSO4 (0, 10, 20, and 40 mg/kg) for 21 and 42 days by gavage. The results verified that CuSO4 decreased the content of mitochondrial respiratory chain complexes I–IV in mouse liver. CuSO4 treatment resulted the decrease in the protein and mRNA expression levels of PGC‐1α, TFAM, and NRF1, which were the mitochondrial biogenesis regulator proteins. Meanwhile, the proteins involved in mitochondrial fusion were reduced by CuSO4, such as Mfn1 and Mfn2, however, mitochondrial fission proteins Drip1 and Fis1 were significantly increased. Abovementioned results show that CuSO4 could induce mitochondria damage in the liver of mice, and mitochondrial biogenesis and mitochondrial dynamics are involved in the molecular mechanism of CuSO4‐induced hepatotoxicity.
Shaping the chromatin landscape at rRNA and tRNA genes, an emerging new role for RNA polymerase II transcription?
Authors: Yague‐Sanz Carlo 
Published: December 2023

AbstractEukaryotic genes must be condensed into chromatin while remaining accessible to the transcriptional machinery to support gene expression. Among the three eukaryotic RNA polymerases (RNAP), RNAPII is unique, partly because of the C‐terminal domain (CTD) of its largest subunit, Rpb1. Rpb1 CTD can be extensively modified during the transcription cycle, allowing for the co‐transcriptional recruitment of specific interacting proteins. These include chromatin remodeling factors that control the opening or closing of chromatin. How the CTD‐less RNAPI and RNAPIII deal with chromatin at rRNA and tRNA genes is less understood. Here, we review recent advances in our understanding of how the chromatin at tRNA genes and rRNA genes can be remodeled in response to environmental cues in yeast, with a particular focus on the role of local RNAPII transcription in recruiting chromatin remodelers at these loci. In fission yeast, RNAPII transcription at tRNA genes is important to re‐establish a chromatin environment permissive to tRNA transcription, which supports growth from stationary phase. In contrast, local RNAPII transcription at rRNA genes correlates with the closing of the chromatin in starvation in budding and fission yeast, suggesting a role in establishing silent chromatin. These opposite roles might support a general model where RNAPII transcription recruits chromatin remodelers to tRNA and rRNA genes to promote the closing and reopening of chromatin in response to the environment.
Introduction
Authors: Aigner Wolfgang , Miksch Silvia , Schumann Heidrun , Tominski Christian 
Published: December 2023

AbstractSpace and time are two outstanding dimensions because, in conjunction, they represent the four-dimensional space or simply the world we are living in. Basically, every piece of data we measure is related and often only meaningful within the context of space and time. Consider, for example, the price of a barrel of oil. The data value of $129 alone is not very useful. Only if assessed in the context of where (space) and when (time) is the oil price valid, and only then it is possible to meaningfully interpret the cost of $129.
Crafting Visualizations of Time-Oriented Data
Authors: Aigner Wolfgang , Miksch Silvia , Schumann Heidrun , Tominski Christian 
Published: December 2023

AbstractMany different types of data are related to time. Meteorological data, financial data, census data, medical data, simulation data, news articles, photo collections, or project plans, to name only a few examples, all contain temporal information. In theory, because all these data are time-oriented, they should be representable with one and the same visualization approach. In practice, however, the data exhibit specific characteristics and hence each of the above examples requires a dedicated visualization.
Conclusion
Authors: Aigner Wolfgang , Miksch Silvia , Schumann Heidrun , Tominski Christian 
Published: December 2023

AbstractThis chapter briefly summarizes the content of the book and describes practical concerns of visualizing time-oriented data in real-world data settings. Visual analytics is briefly outlined as a modern approach that combines visualization, interaction, and computational analysis more tightly to facilitate data analysis activities better. Finally, research opportunities for future work are discussed.
Introduction
Authors: Eleonorasdotter Emma 
Published: December 2023

AbstractThis book is based on an ethnological study of Swedish women’s everyday drug use. A queer phenomenological perspective, paying specific attention to class and gender, is used to analyse the accounts of twelve women aged 25–65 years. The book takes into account the central and increasing role of psychoactive substances in contemporary everyday life, and explores the women’s paths and considerations in relation to their use of drugs. The women in the study use different kinds of stigmatised substances in markedly different ways, and this provides access to perspectives on everyday life from somewhat queer, but not uncommon, angles.The book further problematises how gender and class affect the directions and experiences of lives lived under the effect of drugs, in relation to cultural and societal conceptions of drugs, drug use and people who use drugs. It explores themes based on respondents’ discussions about topics such as stigma, happiness, children, the body, gifts, the drug market, medication, sickness and health. To do this, the book first provides a detailed, contextualising background to drug use in Sweden and the Western world, based on an interdisciplinary weaving together of research and cultural media representations. It provides the reader with historical, sociological, criminological, pharmacological, medical, political, cultural and ethnographic takes on and reflections about the role of drugs and people who use drugs from an intersectional perspective, with a specific focus on class and gender.
Is It Ok to Laugh?
Authors: Eleonorasdotter Emma 
Published: December 2023

AbstractThis chapter focuses on the drug-use-related expression of laughter. The discussion about research ethics linked to the interviewees’ positive feelings evoked by drug use is deepened, with a focus on subsequent laughter and humour as aspects of drug use. The chapter explores the meaning of laughing at drug use from a gender perspective, and the specificity in the pattern of the funny stories the women told. These narrations challenge the stereotype of them as mad, sad and bad in positioning them as mad, but funny and even heroic in their madness.
Staying Appropriate
Authors: Eleonorasdotter Emma 
Published: December 2023

AbstractThis chapter examines how the influence of drugs is lived and embodied, and how the fusion of bodies and drugs creates proximities to and distances from other bodies and objects in both time and space. The temporal rhythm of restraint and release that is key in modern consumer societies is analysed in relation to drug use, along with the spatial organisation of the appropriate and the inappropriate. This organisation means that drug use is expected in certain times and places, while in others it is hidden. Carolina describes the work of hiding as central to her previous everyday life as someone who used amphetamines, which furthers the discussion of the spatial exclusion of people who use drugs initiated in the previous chapter.
Einführung und Überblick
Authors: Gleißner Werner , Weissman Arnold 
Published: December 2023

ZusammenfassungDie wirtschaftlichen Rahmenbedingungen können für einen großen Teil der deutschen Unternehmen, speziell den mittelständischen Familienunternehmen, spätestens seit dem Jahr 2020 als „sehr herausfordernd“ bezeichnet werden. Dies belegen die Ergebnisse der volkswirtschaftlichen Risikoforschung.
Fazit und Ausblick
Authors: Herzberg Laura 
Published: December 2023

ZusammenfassungDie vorliegende Arbeit analysierte den Internationalismus OKAY in schriftlicher Interaktion im Internet. Die Arbeit zielte darauf ab, die Bandbreite aktueller OKAY-Verwendungen um schriftliche OKAYs in internetbasierten Kommunikationsformen zu erweitern. Dabei stand die Analyse von interaktionsorientierten Wikipedia-Diskussionsbeiträgen der deutschen, englischen und französischen Wikipedia-Sprachversionen in den empirischen Untersuchungen dieser Arbeit im Fokus.
Korpusstudie 2: Positionen von OKAY
Authors: Herzberg Laura 
Published: December 2023

ZusammenfassungKorpusstudie 2 beinhaltet Untersuchungen zu Positionen von OKAY in Wikipedia (WP)-Beiträgen. Ziel dieser Studie ist es, anhand der gezogenen WP-Stichproben die Verteilung der Positionen von OKAY in den deutschen, englischen und französischen WP-Beiträgen zu identifizieren. Bei der Untersuchung zur Position soll ebenfalls überprüft werden, ob ein Zusammenhang zwischen der Position und der Funktion von OKAY vorliegt.
Korpusstudie 3: Funktionen von OKAY
Authors: Herzberg Laura 
Published: December 2023

ZusammenfassungKorpusstudie 3 stellt die umfangreichste aller durchgeführten Untersuchungen dar. Dies ist zum einen auf die höhere Anzahl der Kategorien im Vergleich zu den Positionen zurückzuführen. Zum anderen zielen die Ergebnisse von Korpusstudie 3 auf die Erweiterung und den Ausbau des Funktionsspektrums von OKAY in schriftlicher Interaktion ab.
Diskussion und Zusammenfassung der Korpusstudien
Authors: Herzberg Laura 
Published: December 2023

ZusammenfassungIn drei Korpusstudien wurden Form, Position und Funktion von OKAY auf den deutschen, englischen und französischen Wikipedia-Diskussionsseiten vergleichend analysiert. Bevor die einzelnen Korpusstudien zusammengefasst werden, sollen an dieser Stelle einige Einschränkungen der empirischen Untersuchungen angeführt werden.
Modular Hamiltonian for de Sitter diamonds
Authors: Fröb Markus B. 
Published: December 2023

Abstract
We determine the Tomita-Takesaki modular data for CFTs in double cone and light cone regions in conformally flat spacetimes. This includes in particular the modular Hamiltonian for diamonds in the de Sitter spacetime. In the limit where the diamonds become large, we show that the modular automorphisms become time translations in the static patch. As preparation, we also provide a pedagogical rederivation of the known results for Minkowski spacetime. With our results and using the Araki formula, it becomes possible to compute relative entanglement entropies for CFTs in these regions.
The cosmological tree theorem
Authors: Salcedo Santiago Agüí , Melville Scott 
Published: December 2023

Abstract
A number of diagrammatic “cutting rules” have recently been developed for the wavefunction of the Universe which determines cosmological correlation functions. These leverage perturbative unitarity to relate particular “discontinuities” in Feynman-Witten diagrams (with cosmological boundary conditions) to simpler diagrams, in much the same way that the Cutkosky rules relate different scattering amplitudes. In this work, we make use of a further causality condition to derive new cutting rules for Feynman-Witten diagrams on any time-dependent spacetime background. These lead to the cosmological analogue of Feynman’s tree theorem for amplitudes, which can be used to systematically expand any loop diagram in terms of (momentum integrals of) tree-level diagrams. As an application of these new rules, we show that certain singularities in the wavefunction cannot appear in equal-time correlators due to a cancellation between “real” and “virtual” contributions that closely parallels the KLN theorem. Finally, when combined with the Bunch-Davies condition that certain unphysical singularities are absent, these cutting rules completely determine any tree-level exchange diagram in terms of simpler contact diagrams. Altogether, these results remove the need to ever perform nested time integrals when computing cosmological correlators.
Twisted holography without conformal symmetry
Authors: Budzik Kasia , Gaiotto Davide 
Published: December 2023

Abstract
We discuss the notion of translation-invariant vacua for 2d chiral algebras and relate it to the notion of the associated variety. The two-dimensional chiral algebra associated to four-dimensional $$ \mathcal{N} $$
N
= 4 U(N) SYM has a conjectural holographic dual involving the B-model topological string theory. We study the effect of non-zero vacuum expectation values on the chiral algebra correlation functions and derive a holographic dual Calabi-Yau geometry. We test our proposal by a large N analysis of correlation functions of determinant operators, whose saddles can be matched with semi-classical configurations of “Giant Graviton” D-branes in the bulk.