bluuebunny/crossref_metadata_2025_split huggingface dataset:
The McMaster Internal Medicine Royal College Review Course: Descriptions of a Novel Program and a Survey of Participants
Authors: Carayannopoulos Kallirroi Laiya , Dadwal Shivani , Laureano Marissa , Neary John , Martin Leslie , Lewis Kimberley 
Published: December 2023

Background Certification exams are the final hurdle residents overcome to complete training. Despite their high-stakes nature there are few dedicated preparation resources. In response, we created the McMaster Internal Medicine Royal College Review Course and administered a survey to participants to assess the design of the course and its perceived value. Methods The course was offered as three-hour lectures hosted every one to two weeks for a total of 15 sessions. Each session was dedicated to a specific subspecialty. Following completion of the exam, we distributed a survey to participating residents. Three iterations of this course were studied between 2018-2021. Results 112/139 residents completed the survey. 92.8% of participants found the course valuable and 70.6% felt it helped to reduce exam anxiety. Most participants (78.6%) engaged with the course during the presentations and used the resources for review during independent study. Conclusion This review course presents a valuable exam preparation resource for residents. This survey demonstrated a desire for the course to continue and may present an opportunity for other residency programs to offer similar courses.
Elsberg Syndrome – Under-Recognition of HSV-2 Lumbosacral Radiculitis among Canadians
Authors: Shah Meera , Patel Sagar , Kufiashi Hala , Kapoor Andrew 
Published: December 2023

Elsberg syndrome is an underrecognized entity characterized by urinary retention, sacral radiculitis, and cerebrospinal fluid pleocytosis, associated with either an acute infection or herpes-simplex 2 virus (HSV-2) reactivation. With HSV-2 prevalence among Canadians averaging 10-15%, awareness of atypical presentations and potential complications is critical for clinicians. Early recognition and treatment may help improve patient outcomes and decrease neurologic disease morbidity, including neuropathic pain, chronic urinary retention, and paraplegia. Here, we report a case of Elsberg syndrome in a 56-year-old female with no known history of prior HSV-2 infection who presented with sacral radiculitis, myelitis, urinary retention, and a positive cerebrospinal fluid HSV-2 PCR. We use this case to illustrate the key clinical, diagnostic, and radiographic features clinicians should be familiar with in clinical practice. Elsberg syndrome is an uncommon but significant neurological manifestation of HSV-2, and improved recognition of Elsberg syndrome may lead to more timely diagnosis, treatment, and improved neurologic outcomes.
RésuméLe syndrome d’Elsberg est une entité méconnue caractérisée par une rétention urinaire, une radiculite sacrée et une pléiocytose du liquide céphalorachidien, associées à une infection aiguë ou à une réactivation du virus herpès- simplex 2 (HSV-2). La prévalence du HSV-2 au Canada étant en moyenne de 10 à 15 %, il est essentiel que les cliniciens soient conscients des présentations atypiques et des complications potentielles. La reconnaissance et le traitement précoces peuvent contribuer à améliorer l’état des patients et à réduire la morbidité des maladies neurologiques, notamment la douleur neuropathique, la rétention urinaire chronique et la paraplégie. Nous rapportons ici un cas de syndrome d’Elsberg chez une femme de 56 ans sans antécédents connus d’infection par le HSV-2, qui présentait une radiculite sacrée, une myélite, une rétention urinaire et une PCR HSV-2 positive dans le LCR. Nous utilisons ce cas pour illustrer les principales caractéristiques cliniques, diagnostiques et radiographiques que les cliniciens doivent connaître dans leur pratique clinique. Le syndrome d’Elsberg est une manifestation neurologique peu fréquente mais significative du HSV-2 et une meilleure reconnaissance du syndrome d’Elsberg peut conduire à un diagnostic et à un traitement plus rapide et à de meilleurs résultats neurologiques.
An Online Photovoice Study Designed by Researchers from Art and Social Work to Better Understand the Experience of Chronic Pain by Women of Color
Authors: Prophet Jane , Rahman Rahbel , L. Hassett Afton 
Published: December 2023

In 1980s British feminist artist-photographer Jo Spence used phototherapy to challenge normative and medicalized constructions of the female cancer patient by documenting her illness and was then employed as a consultant by hospitals who, through her work, recognized the need to change physicians’ practices and attitudes, which objectified patients. Photovoice, a Community Based Participatory Design method where participants take photographs and combine them with short text narratives, is similar to Spence’s artistic method. It has been used widely in health and social work settings. Healthcare professionals are aware of the power of images as catalysts for meaning making in medical encounters with people in pain; as part of multidisciplinary analysis, because images can enhance a person’s sense of agency in relation to their pain, especially in clinical contexts. Photographs can also establish a common ground for discussing meaning, therefore Photovoice can make the hidden experience of pain visible through collaborative photo-texts. These are subsequently shared with other patients and healthcare workers to aid them in specialist consultations. However, few studies have addressed gender and race-related health disparities in treating chronic pain. This paper draws on the authors’ study with twenty women of color who created photo-text works about their experiences living with and being treated for chronic pain. In this novel online Photovoice study, participants engaged with asynchronous videos created by an artist-professor about the meanings viewers make of a photograph, including how perspective, angle, and lighting can affect the viewer’s emotional response to photographs. Participants then deployed Photovoice through six synchronous sessions led by a social work professor with extensive experience designing and facilitating Photovoice studies. The resulting image-text works by study participants address health inequity and argue for health equity as a hallmark of social justice in healthcare by focusing on exposing and reducing healthcare disparities.
Transgenic Embryo Implantation Excerpts from The Life Cycle of The Programmed Mouse, an Art and Biology Residency in an Experimental Animal Production and Research Facility
Authors: Zaretsky Adam 
Published: December 2023

This is an excerpt from a record of a bioart residency in the transgenic mouse production facility at i3S, University Porto, Porto, Portugal, EU 2022: Art/sci research-creation, field notes and bioart from the i3S transgenic mouse production facility. The transgenic mouse production facility at i3S is an animal facility that breeds specific transgenic mutants for lab research. This means that the mice are genetically modified and bred to produce stable litters of similarly mutant pups. In other words, the mice are genetically modified in such a way that their offspring are altered in a specific hereditary and multigenerational way.
Covering the life cycle of the programmed mouse, we asked for hands-on experience as much as possible and learned through doing/witnessing: mouse sperm/egg collection, cryopreservation, fertilization, embryo mutagenic microinjection, implantation of embryos in a pseudopregnant surrogate, embryo dissection for tissue culture, surgery, breeding, and euthanasia. Delving into software studies, there was an exploration of CRISPR/vector design apps and transgenic animal facility management apps. We also accessed global networks for stable pedigree proof of genomic standardization as well as animal care and use in the transgenic core. Learning that the mice were often disease models, created to infect with live contagious diseases or inborn with developmental disabilities (degenerative enhancements), we arranged for some animal enrichment arts. Learning of the often-difficult life of scientists and graduate students, we also took the time to enrich the scientists with an action painting to live music enrichment lab. This form of in depth and experiential research is an advanced version of medical anthropology or science technology studies field working with subjective, literary, informed, morbid, and humorous artistic outcomes.
7TH INTERNATIONAL SYMPOSIUM “SMART LION”. REHABILITATION IN UKRAINE, SEPTEMBER 26, 2023
Authors: Bekesevych Anna , Lazko Alla , Hresko Ihor 
Published: December 2023

The seventh international symposium, SMART LION, was held on September 26, 2023. It was to celebrate the 150th anniversary of the Shevchenko Scientific Society and the 125th anniversary of the Medical Commission. The topics concerned the challenges our country faces today. Organizers of SMART LION 2023 are Professors Valentyna Chopyak, Oksana Zayachkivska, and Vassyl Lonchyna. They managed to gather almost two hundred participants offline and over a thousand guests online.
Olena Lazareva, Vira Rokoshevska, Oleh Bilianskyi, Oksana Hdyria, and Oleh Fitkalo delivered their reports on the development of rehabilitation in Ukraine and its main avenues.
The emergence of post-traumatic stress disorder (PTSD) is a critical challenge for contemporary Ukraine and has long been a significant obstacle for global medicine. That is the reason why Oleh Berezyuk, Head of the Mental Health Service of the UNBROKEN National Rehabilitation Center, brought up the matter of difficulties in correctly diagnosing and treating PTSD in the context of a multidisciplinary hospital, while Professor Valentyna Chopyak and MD Svitlana Zubchenko focused the attention of attendees on PTSD immune-rehabilitation.
During the concluding block of the symposium, which focused on the contemporary interpretation of physical therapy and occupational therapy, as well as interprofessional education, communication, and cooperation, attendees were afforded the chance to listen to highly intriguing reports presented by Renata Roman (Canada), Ellen Godwin (USA), Karl J. Sandin (USA), David Omut (USA), and Oksana Zayachkivska (Ukraine, USA).
The scientific event concluded with a round table on the future of physical therapy and rehabilitation in Ukraine, with its outcomes leading to the resolution of the seventh international symposium, SMART LION 2023.
CYTOKINE-MODULATING INFLUENCE OF HIPEC ON THE INTRAPERITONEAL HOMEOSTASIS FORMATION IN PATIENTS WITH OVARIAN CANCER
Authors: Fetsych Markiyan , Igumentseva Natalia , Ferneza Severyn , Yarema Roman , Volodko Natalia 
Published: December 2023

Background: Ovarian cancer (OC) has the greatest mortality rate among oncogynecological diseases. Most cases are diagnosed at the peritoneal dissemination stage, resulting in radical treatment. Most cases (75%) are diagnosed in III-IV stages at the stage of peritoneal dissemination, making the radical treatment impossible. Intraoperative hyperthermic intraperitoneal chemoperfusion (HIPEC), which has ceased to be an experimental technique over the past decade, is increasingly used among the methods of combating peritoneal carcinomatosis and demonstrates an increase in recurrence-free and overall survival in advanced stages of OC. Nevertheless, certain pathophysiological aspects of the effect of HIPEC on intra-abdominal homeostasis, and therefore on the further course of the disease, have not been elucidated. However, understanding this effect may be the key to the successful application of HIPEC and predicting its efficacy in each case of OC.
Objectives: To access changes in intraperitoneal homeostasis in patients with advanced OC after HIPEC procedure (as a stage of cytoreductive surgery); in particular, to evaluate changes of TNF and TGF-β expression under the influence of HIPEC and systemic chemotherapy in the OC microenvironment.
Materials and methods: The study included 33 OC patients treated at Lviv Regional Cancer Centre in 2016–2020. Twelve of them received HIPEC. The primary tumor cultures and primary cultures of peritoneal mesothelium and macrophages were obtained for all patients. The cytokines TNF and TGF-β activity were determined in their conditional media.
Results: The decrease of TNF and TGF-β concentrations in the drainage exudate after HIPEC was revealed compared with the same parameters in the ascitic fluid before the operation. One-hour hyperthermia of the primary culture of peritoneal ascites-associated macrophages of recurrent OC patients decreased the TNF level in conditional media. A decline was found in 10 out of 12 cases.
Conclusions: HIPEC has a cytokine-modulating effect on the intra-abdominal homeostasis of patients with OC, suppressing TNF expression by peritoneal macrophages. Reduced activity of TNF in supernatants of OC primary tumor cultures was associated with higher sensitivity to chemotherapy.
CLINICAL, ULTRASOUND AND CYTOGENETIC CHARACTERISTICS OF FETUSES WITH INCREASED NUCHAL TRANSLUCENCY THICKNESS IN THE FIRST TRIMESTER OF PREGNANCY
Authors: Prokopchuk Natalia , Nikolenko Marharyta , Lozynska Mariya , Antoniuk Olha , Korinetz Yaroslav , Ivaniv Yuriy 
Published: December 2023

Background: Improving programs for early prenatal detection of congenital malformations remains a relevant scientific and practical problem. The prevalence of congenital anomalies in Ukraine is 23.7:1000 among live-born babies, and there is no significant decrease in it. The aim of this study was to compare clinical, ultrasound and cytogenetic data in swollen fetuses with increased nuchal translucency (NT) thicknesses from the group of pregnant women in the first trimester at high genetic risk to optimize the algorithm of prenatal diagnostics.
Materials and Methods: Clinical examinations, ultrasound diagnostics, invasive methods of prenatal diagnostics (chorion biopsy, amniocentesis), genetic testing techniques, such as karyotyping and FISH, genetic counseling and statistical analysis were carried out. The results of complex examinations of 127 fetuses with an increased NT thickness from the group of pregnant women were analyzed. Fetuses were divided into two groups with an NT thickness of 2.5–3.5 mm (group 1) (38 cases) and with an NT above 3.5 mm (group 2)(89 cases).
Results: Among pregnancies with fetuses with an increased NT thickness, there were 65.4% cases of adverse outcomes with chromosomal pathology (69.9%), congenital malformations of non-chromosomal etiology (25.3%) and pregnancy loss (4.8%). The frequency of chromosomal abnormalities in fetuses of group 1 was 55.3% and 41.6% in group 2. Congenital malformations of various systems and organs in fetuses, the most frequent of which were cardiac defects, were diagnosed. The ratio of congenital heart defects in the fetuses of groups 1 and 2 was 23.7% and 43.8%, respectively (p=0.03; OR=0.40).
Conclusion: There is no significant difference between the frequency of chromosomal abnormalities in the fetuses of group 1 compared to group 2, which indicates a high informative value of an increased NT thickness, including the thickness of 2.5–3.5 mm in fetuses in the first trimester as a marker of chromosomal pathology. A significantly higher incidence of congenital malformations of non-chromosomal etiology was found in fetuses with venous duct pathology and NT thickness over 3.5 mm compared to fetuses with the same pathology and NT thickness of 2.5–3.5 mm. Proposed changes to the management algorithm for pregnant women with swollen fetuses include mandatory congenital heart defects screening in the first trimester.
Selection of Primer Location for qMSP Analysis of Alu Methylation Level in Vietnamese Patients with Breast Cancer
Authors: Thi Quynh Trang Tran , The Tung Pham , Thi Than Nguyen , Lan Vo Thi Thuong 
Published: December 2023

In the mammalian genome, DNA methylation occurs at the cytosine in CpG complexes. Changes in genomic DNA methylation status, reflected by the CpG methylation status of the retrotransposon Alu elements, are closely related to the initiation and development of cancer. Abnormalities in Alu methylation have been documented in many early-stage tumors where the Alu methylation level correlates with cellular malignancy. Therefore, the assessment of Alu methylation level as a biomarker for early diagnosis and prognosis has been of interest in many types of cancer. Our study aims to investigate the nucleotide positions on the CpG-rich sequence of Alu for the design of primers used for quantitative methylation-specific PCR reaction (qMSP). Using two primer pairs designed from the 5' Alu region for analysis of the Alu methylation level in 25 pairs of cancer/adjacent tissue samples of Vietnamese patients with breast cancer, we find out the primer pair that significantly distinguished the Alu methylation status between cancer and adjacent tissue samples. Selecting the right qMSP primer pair will facilitate the profiling of Alu methylation levels in breast cancer samples when compared with non-cancerous samples, thereby determining its potential in becoming an epigenetic marker for early diagnosis, prognosis as well as in supporting breast cancer treatment to be more effective in Vietnam.
Keywords: Alu methylation, breast cancer, primers of qMSP.
Stigma, Help-seeking and Factors Associated with Mental Health Literacy in Adults: A Literature Review
Authors: Bach Nguyen Xuan , Ngoc Bich Nguyen , Hoang Anh Dang 
Published: December 2023

The article aims to review domestic and foreign research to provide information about the current condition of two of the three aspects of mental health literacy, namely stigma, and help-seeking, and the related factors to understand impact measures to help improve the adults' mental health literacy. This study uses a literature review method with English and Vietnamese keyword searching on PubMed and Vietnamese journals. Results show that stigma happens to be higher in Asian regions than in Australia, Europe, and America. Reducing stigma will improve treatment effectiveness and enhance the mental health literacy of individuals and communities. Regarding help-seeking, it shows that the rate of seeking help ranges from 28.2% to 76.9%. People with low mental health literacy are often less likely to seek help. Age, gender, education level, income, employment position, marital status, medical history, and alcohol use history are factors related to mental health literacy. Previous studies have shown that people with higher knowledge tend to seek help, while those with less stigma have a higher ability to seek help.
Keywords: Related factors, mental health literacy, adults, stigma, help-seeking.
Formation and development of criminal liability for crimes infringing on fair competition
Authors: Danilovskaia Anna Vladimirovna 
Published: December 2023

The subject of the study is the legal foundations of Russia's criminal law policy in the field of fair competition protection in their historical development, namely the sources of Russian legislation of the XVIII-XXI centuries, containing grounds for criminal liability for encroachments on fair competition, legal acts regulating competitive relations, as well as scientific research by scientists of the XIX-XXI centuries, including dissertations, scientific publications on aspects of legal regulation of competitive relations, criminal prosecution for encroachments on them.The purpose of the work is to identify the historically conditioned attitude of the Russian state towards encroachments on fair competition, their criminalization, penalization and differentiation of responsibility for their commission, systematization of crimes against fair competition, as well as to study the legislative technique used in the formulation of criminal law prohibitions. The main method of research was the historical method, which allowed us to study the genesis of domestic criminal legislation, which provided for liability for encroachments on fair competition. The logical, comparative method, the method of system analysis, and classification were also used. The main result of the work is the conclusion about the usefulness of taking into account domestic legislative experience in determining the criteria for criminalizing acts that infringe on fair competition, systematizing crimes against fair competition, methods and techniques for formulating criminal law prohibitions against their commission. The novelty of the research lies in the fact that the conducted analysis of domestic legislation can help in substantiating and making decisions of criminal and political significance in relation to understanding the system of crimes against fair competition, criminalization of socially dangerous acts directed against fair competition, their penalization, differentiation of responsibility for their commission, the application of existing criminal legislation and their improvement. The findings can be especially useful in legislative and scientific activities, as well as in the field of education.
Innovative History Learning through Virtual Field Trips Model
Authors: Moh. Imron Rosidi  , Disman  , Kokom Komalasari  , Erlina Wiyanarti  
Published: December 2023

The purpose of this research is to create an innovative history learning model by using a virtual field trip model. The problem will be studied in this study are: (1) what is the essence reality in learning history? (2) how is the application of the virtual field trip model to a history learning? Research method selected for this study is a literature study where the data material needed are obtained from books, journals, encyclopedias, articles and others. According to the study result, it defines a learning history is a teaching and learning activity regarding past events with conveyed meaning for the present. Within its development process in responding to the Covid 19 pandemic, an innovative virtual field trip model was created and designed to make students able to play an active role in the history learning process which can be seen from the following syntax: (1) Determining the learning materials, (2) Guiding the group/individual investigations, (3) Presenting the result of students’ investigation and (4) Evaluation. Keywords: Learning Model, History Learning, Virtual Field Trips
Student Engagement Models: Parental Support, Academic Self-Efficacy, and the Teacher-Student Relationship
Authors: Eny Purwandari  , Khoirunnisa  
Published: December 2023

Student engagement is the basis for academic and social success in online learning. The study aimed to examine the measurement and structural models and empirically test the relationship between parental support, academic self-efficacy, teacher-student relationship, and student engagement. The number of research samples was 323 junior high school students in Cirebon City, coming from 4 schools (public and private) which were obtained by multistage cluster random. The instrument uses a scale of student engagement, parental support, academic self-efficacy, and teacher-student relationship. Data analysis using structural equation modeling (SEM) with LISREL 8.8 program. The results showed that the overall fit test of the student engagement model was fit: Chi-square (p) = 146.71 (.00), df = 59, RMSEA = .068, SRMR =.05; CFI = .99, NNFI =.99; GFI = .93. The student engagement model is supported by parental support, academic self-efficacy, and the teacher-student relationship. The findings have contributed to strategies for increasing student engagement through parental support, teacher-student relationships, and academic self-efficacy. Keywords: Student Engagement Model, Parental Support, Academic Self-Efficacy