bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated Genomics Reveal Potential Resistance Mechanisms of PANoptosis‐Associated Genes in Acute Myeloid Leukemia
Authors: Liang Cong , Long Zhiqing , Lei Mengjie , Ding Ran , Chen Mengke 
Published: January 2025

ABSTRACTAcute myeloid leukemia (AML) is marked by the proliferation of abnormal myeloid progenitor cells in the bone marrow and blood, leading to low cure rates despite new drug approvals from 2017 to 2018. Current therapies often fail due to the emergence of drug resistance mechanisms, such as those involving anti‐apoptotic pathways and immune evasion, highlighting an urgent need for novel approaches to overcome these limitations. Programmed cell death (PCD) is crucial for tissue homeostasis, with PANoptosis—a form of PCD integrating pyroptosis, apoptosis, and necroptosis—recently identified. This process, regulated by the PANoptosome complex, could be key to overcoming AML drug resistance. Targeting multiple PCD pathways simultaneously may prove more effective than single‐target therapies. Research suggests that disrupting anti‐apoptotic mechanisms, such as those involving Bcl‐2, can enhance drug sensitivity in AML. This study hypothesizes that PANoptosis‐associated resistance genes (PARGs) play a critical role in AML drug resistance by modulating immune responses and offers a multi‐faceted approach to tackle this challenge. Using RNA sequencing data from the Cancer Genome Atlas and Gene Expression Omnibus databases, we performed differential expression analysis to identify significantly dysregulated PARGs in AML. Regression analysis identified prognostic PARGs, bridging a key gap in understanding how these genes contribute to treatment resistance. We then verified their expression in AML cell lines and cell samples treated with cytarabine using RT‐qPCR. Hierarchical clustering revealed distinct PARG expression patterns, and functional enrichment analysis highlighted their involvement in immune‐related pathways. The combination of bioinformatics and experimental validation underscores how these genes may mediate immune modulation in drug resistance, providing a robust framework for further study. Our findings suggest that PARGs contribute to AML resistance by modulating immune responses and provide potential targets for therapeutic intervention. This study highlights the potential of targeting PARGs to improve treatment outcomes in AML. By analyzing the expression changes of these genes in response to standard clinical treatments, we provide a framework for developing multi‐target therapeutic strategies that simultaneously disrupt multiple programmed cell death pathways. Such an approach directly addresses the limitations of current treatments by offering a method to enhance drug sensitivity and mitigate resistance, potentially improving survival rates. Our findings underscore the importance of a comprehensive understanding of PCD mechanisms and pave the way for innovative treatments that could significantly impact AML management.
Acute respiratory distress syndrome (ARDS): from mechanistic insights to therapeutic strategies
Authors: Xie Rongli , Tan Dan , Liu Boke , Xiao Guohui , Gong Fangchen , Zhang Qiyao , Qi Lei , Zheng Sisi , Yuan Yuanyang , Yang Zhitao , Chen Ying , Fei Jian , Xu Dan 
Published: January 2025

AbstractAcute respiratory distress syndrome (ARDS) is a clinical syndrome of acute hypoxic respiratory failure caused by diffuse lung inflammation and edema. ARDS can be precipitated by intrapulmonary factors or extrapulmonary factors, which can lead to severe hypoxemia. Patients suffering from ARDS have high mortality rates, including a 28‐day mortality rate of 34.8% and an overall in‐hospital mortality rate of 40.0%. The pathophysiology of ARDS is complex and involves the activation and dysregulation of multiple overlapping and interacting pathways of systemic inflammation and coagulation, including the respiratory system, circulatory system, and immune system. In general, the treatment of inflammatory injuries is a coordinated process that involves the downregulation of proinflammatory pathways and the upregulation of anti‐inflammatory pathways. Given the complexity of the underlying disease, treatment needs to be tailored to the problem. Hence, we discuss the pathogenesis and treatment methods of affected organs, including 2019 coronavirus disease (COVID‐19)‐related pneumonia, drowning, trauma, blood transfusion, severe acute pancreatitis, and sepsis. This review is intended to provide a new perspective concerning ARDS and offer novel insight into future therapeutic interventions.
Asian American Parenting and Youth Mental Health Outcomes: A Literature Review
Authors: Yu Toni , Yuen Connie , Yu Zhiyuan 
Published: January 2025

ABSTRACTContrary to the “model minority” stereotype of being exceptionally healthy and successful, Asian American (AA) youth experience mental health disparities and are less likely to seek help. In 2020, suicide was the leading cause of death for AA youth aged 10–19. Parenting is essential for promoting youth mental health, and AA parenting is unique in the context of acculturation and enculturation. However, the impact of parenting on youth mental health among AA families remains underexplored and unsynthesized. This review aims to synthesize existing literature from 2003 onward on parenting and mental health outcomes among AA youth. Four databases were searched, yielding 44 articles published after 2003 for inclusion. Empirical studies meeting the following criteria were included: population focused on AA youth, study conducted in the U.S., included a mental health outcome, and included a parenting measure. Findings emphasize the importance of parenting in shaping the mental health outcomes of AA youth. Intergenerational acculturation gaps and family conflicts are associated with increased mental health risks, while parental warmth/support and family cohesion serve as protective factors. These findings highlight the need for culturally tailored parenting interventions to improve AA youth mental health. Future research should evaluate or adapt existing evidence‐based parenting programs to ensure cultural appropriateness and effectiveness in improving mental health of AA youth, ultimately reducing mental health disparities.
Transient shear wave elastometry using a portable magnetic resonance sensor
Authors: Selby William , Garland Phil , Mastikhin Igor 
Published: January 2025

AbstractPurposeMagnetic resonance elastography (MRE) provides detailed maps of tissue stiffness, helping to diagnose various health conditions, but requires the use of expensive clinical MRI scanners. Our approach utilizes compact, cost‐effective portable MR sensors that offer bulk characterization of material properties in a region of interest close to the surface (within 1–2 cm). This accessible instrument could enable routine monitoring and prevention of diseases not readily evaluated with conventional tools.MethodsThe method was tested on tissue‐mimicking phantoms with varying stiffness. The gels were excited with acoustic pulses (one cycle of a sinusoidal waveform) at a fixed distance from the MR sensor. A series of delays between acoustic excitation and MR signal detection allowed time for the pulse to travel to the sensitive region.ResultsThe “arrival time” of the shear wave, determined by the time‐dependent MR signal response, was used to calculate the shear wave speed. MR measurements of shear wave speed were compared with optical sensor measurements and manufacturer‐tabulated values, aligning with expected relative differences between samples.ConclusionA portable MR‐based transient elastometry technique for measuring tissue elasticity was developed and demonstrated on tissue‐mimicking phantoms. Future improvements include using a new portable magnet to investigate depth‐dependent changes in elasticity in stratified samples and integrating MR relaxation and diffusion measurements for comprehensive tissue analysis. This approach can complement conventional MRE in applications where a portable, affordable, and localized assessment of tissue stiffness is required.
Clinical Significance of Intracerebral Multiple SWI Low Signal Intensities on MRI in Patients With Extracerebral Sepsis
Authors: Koike Hirofumi , Morikawa Minoru , Ideguchi Reiko , Toya Ryo 
Published: January 2025

ABSTRACTBackground and PurposeSepsis can cause sepsis‐associated encephalopathy and resulting disorder of consciousness, with small hemorrhagic lesions visible in SWI. We aimed to investigate the clinical significance of these small lesions, termed multiple SWI low signal intensities, in patients with sepsis‐associated encephalopathy.MethodsWe retrospectively examined the SWI scans of 107 patients, of whom 18 had multiple SWI low signal intensities on MRI and 89 did not. We then compared clinical data between the two patient groups. Furthermore, we scored the numbers of these low signal intensities (0 lesions: 0 points; 1–2 lesions: 1 point; 3–10 lesions: 2 points; > 10 lesions: 3 points) in each of seven locations (subcortical, anterior/posterior circulation of cerebral white matter, basal ganglia, corpus callosum, brainstem, and cerebellum). We then investigated the correlations between total multiple SWI low signal intensity scores and sepsis severity.ResultsCompared with the group without multiple SWI low signal intensities, the group with these intensities had significantly higher sequential organ failure assessment scores (p < 0.001), fibrinogen degradation products (p < 0.001), D‐dimer (p < 0.001), procalcitonin (p < 0.001), and bacteremia rates (p = 0.007). They also had lower Glasgow Coma Scale scores (p < 0.001). Furthermore, total multiple SWI low signal intensity scores were negatively correlated with Glasgow Coma Scale scores (R = −0.5942, p = 0.0093) and positively correlated with procalcitonin (R = 0.5094, p = 0.0308).ConclusionsIntracerebral multiple SWI low signal intensities were relatively common following extracranial sepsis and correlated with sepsis severity and disorder of consciousness.
Optimizing CT Scan Parameters for Dry Archaeological Bones: A Qualitative Study as a First Step Towards Standardizing CT Acquisition Protocols
Authors: Martin‐Champetier Antoine , Petit Philippe , Dabadie Alexia , Lasorak Marin , Chaumoitre Kathia , Panuel Michel , Ardagna Yann 
Published: January 2025

ABSTRACTEven though the use of CT scan examinations is often required in paleopathology, the method for performing a CT scan on archaeological dry bones has received little attention. Eight different CT acquisition parameters and positions on the CT table were evaluated using five healthy tibiae (including three immature bones), four healthy vertebrae (including three immature bones), and four pathological mature bones, all in a good state of preservation. The images obtained were blindly evaluated in a psychophysical and subjective manner by four evaluators with varying levels of experience in radiology. The evaluators preferred a tube voltage of 100 kV or less, or expressed no preference, in 90.4% of cases (p < 0.001). For tube current, no preference was noted in 57.7% of cases (p < 0.001), but when a preference was given, a value between 100 and 200 mAs was chosen in 95.5% of cases. The thinnest slices and centered positioning within the gantry, both vertically and laterally, were favored in 100% of cases (p < 0.001). There was no preference for the size of the field of view in 42.3% of cases. The positioning of the bone in the headrest was preferred in 71.2% of cases (p < 0.001), particularly for immature bones. Preferences regarding the elevation of the bone using a cardboard box were not significant (p = 0.07). We therefore recommend using a tube voltage of 80 kV, a tube current between 100 and 200 mAs, the thinnest possible slice thickness, and a field of view minimized according to the CT scanner's capabilities. Bones should be positioned in the headrest, perfectly centered both vertically and laterally within the gantry. However, these conclusions are based on a limited number of bones and types of bones, all in a good state of preservation, highlighting the need for further research.
Examining the Relationship Between Daily Academic Hassles, Academic Buoyancy, Flourishing, and Mental and Physical Health Issues Among Taiwanese High School Students
Authors: Wang Chih‐Hung , Hong Fu‐Yuan , Hsu Tzu‐Yuan 
Published: January 2025

ABSTRACTPrevious studies have explored the relationship between students' school stress and resilience but have largely overlooked the relationship between students' daily academic hassles and buoyancy. Although the close relationship between academic buoyancy and achievement has been confirmed, using the academic buoyancy perspective to explain the relationship between flourishing and mental health problems is lacking in current research. Therefore, this study analyzes the relationship between four variables: daily academic hassles, academic buoyancy, flourishing, and mental health problems among Taiwanese high school students. This study's major contributions are as follows: (1) this study found that daily academic hassles can negatively predict academic buoyancy; (2) academic buoyancy can positively predict flourishing; (3) daily academic hassles can negatively predict flourishing and positively predict physical and mental health problems; (4) academic buoyancy negatively predicted physical and mental health problems; (5) the negative correlation between flourishing and physical and mental health problems; (6) the relationship between daily academic hassles and physical and mental health problems is mediated by academic buoyancy and flourishing. Finally, the study discusses the results and proposes relevant recommendations for schools, teachers, students, and future research.
An Empty Scoping Review of Emergency Department to School Transition for Youth With Mental Health Concerns
Authors: Henderson Smith Lora , Warren Emily , Hendrickson Natalie , Joshua Kate 
Published: January 2025

ABSTRACTThe number of youth emergency department (ED) visits due to mental health concerns has been steadily increasing with a large number of youth being referred from school. Despite the increase in ED visits, there has not been an increase in the number of students who are actually admitted to the hospital. Furthermore, youth referred from school are more likely to be discharged from the ED. Given the unique relationship between school and ED referrals and the large number of youth who do not require hospitalization, this study sought to understand how schools are supporting students who return to school after an ED visit. We conducted a scoping review to identify programs and practices to support ED‐to‐school transition. Two reviewers screened 907 manuscripts, but none of the manuscripts met the inclusion criteria. We discuss the importance of supporting students returning to school from the ED and draw from the literature on hospital‐to‐school transition to make recommendations for school psychologists and educators more broadly.
How Teachers' Mindsets of Empathy Influence Compassion Fatigue: Serial Mediating Roles of Empathy and Professional Identity Among Chinese Kindergarten Teachers
Authors: Chen Fangyan , Ge Yabo , Zhang Yiwen , Song Sheng , Xu Wenjun 
Published: January 2025

ABSTRACTThe field of education has long emphasized the importance of kindergarten teachers perceiving and understanding students' thoughts and feelings and expressing concern, commonly referred to as teacher empathy. However, little work has focused on the “cost of caring,” such as compassion fatigue, particularly among kindergarten teachers, which poses a significant threat to their physical and mental health. To identify the factors that shape compassion fatigue and explore the mechanisms underlying these relationships, a serial mediation model was proposed involving mindsets of empathy, teacher empathy, professional identity, and compassion fatigue. In the present study, self‐report measures were administered to 2256 kindergarten teachers to assess the major variables. The serial mediation model was evaluated using the Process macro software, and the results showed that compassion fatigue can be significantly and negatively predicted by mindsets of empathy, with teacher empathy and professional identity mediating this relationship among kindergarten teachers. These findings substantially contribute to the understanding of compassion fatigue among kindergarten teachers and provide valuable implications for its interventions.
Effective research communication in education: Early years practitioners' views of research summaries
Authors: Woollacott Bethany 
Published: January 2025

AbstractFor educational research findings to impact educational practice, effective communication is essential. One communication device is a summary that consolidates research literature and presents it in a practitioner‐friendly format. There has been little research on how to design educational research summaries effectively, especially not for early years practitioners. In this study, I interviewed eight early years practitioners aiming to understand how they engage with research summaries. I collated a booklet of five research summaries to stimulate discussion during semi‐structured interviews. I identified five overarching themes across the interviews using reflexive thematic analysis, most of which reflected and enhanced findings from the existing research‐practice literature. For example, writing style and aesthetic design affected practitioners' engagement and reading strategies, where practitioners reported issues with excessively ‘wordy’ summaries and summaries written by authors without teaching experience. Practitioners reported lack of time to engage with research, which particularly influenced their preference for explicit practical implications over theoretical knowledge, despite showing that they were capable of critically reflecting on the research given the opportunity. These insights suggest that time—rather than ability—may be particularly problematic for recent attempts encouraging practitioners to actively engage with research. There were also some early years specific barriers, including that most summaries relate to older children who can read or write and therefore have limited relevance for early years. These findings deepen our current understanding of how education practitioners engage with research, providing specific direction for future research which meets practitioners' needs and contributes towards narrowing the research‐practice gap.
Multistage Synchronous Telescopic Manipulator With End‐Effector–Biased Rotating‐Pulling Mode for Damage‐Free Robotic Picking
Authors: Du Xiaoqiang , Meng Zhichao , Wang Yawei , Li Yuechan , Ma Zenghong , He Leiying , Lu Wenwu , Chen Jianneng , Wu Chuanyu , Karkee Manoj 
Published: January 2025

ABSTRACTFruit picking is one of the most time‐consuming and labor‐intensive stages of fruit production, characterized by high labor demands and significant labor costs. Traditional fruit‐picking robotic manipulators typically adopt configurations similar to general‐purpose industrial robots, following a predefined path and employing a direct‐pulling mode to detach the fruit. However, due to the constraints of the orchard environment and the varying conditions of the fruit, manipulators should be designed to accommodate the specific horticultural characteristics of the trees to improve picking efficiency. Additionally, the picking process should be optimized based on the biological characteristics of the fruit to ensure quality. In this study, a five‐degree‐of‐freedom manipulator based on a multistage synchronous telescopic mechanism is proposed for fruit picking. Workspace analysis indicates that the manipulator can cover more than 80% of the fruit distribution on the trees. To ensure motion accuracy, a FreeRTOS‐based motion control system is developed for the manipulator. To evaluate picking efficiency and quality, fruit‐picking experiments are conducted in an apple orchard. A rope‐driven, three‐finger end‐effector is mounted in a biased position at the end of the manipulator, complemented by an RGB‐D camera for fruit detection and a ROS‐based control system for robotic operation. The performance of two picking modes (direct‐pulling and biased rotating‐pulling) are compared in these experiments. The results demonstrate that the biased rotating‐pulling mode yields a higher picking success rate and a lower stem damage rate compared with the direct‐pulling mode. Specifically, the damage‐free success rate for the biased rotating‐pulling mode is 80%, with a 9.18% reduction in stem damage compared with the direct‐pulling mode. Furthermore, the average picking cycle time is approximately 14.5 s. In conclusion, the manipulator and its motion control system successfully achieve efficient, nondestructive fruit picking with a high success rate, offering valuable insights for the development of fully automated fruit‐picking robots in the future.
A One‐Pot Conversion of N‐Ns to N‐Boc Group in Polyamine Synthesis
Authors: Wakabayashi Ryoya , Ohnishi Taiga , Irie Raku , Oikawa Masato 
Published: January 2025

AbstractWe report herein an efficient synthesis of fully Boc‐protected, up to 13‐meric polymer of 1,3‐propanediamine. The synthesis was facilitated by one‐pot conversion of (up to six) N‐Ns groups to N‐Boc groups under conditions of 1) PhSH and Cs2CO3 for deprotection of the Ns group, followed by 2) Boc2O for Boc protection. The average yield per Ns group was extremely high, especially for substrates with four to six Ns groups (94.6%–96.6%).
Family Functioning, Life Satisfaction, and Depressive Symptoms in Chinese Adults With Diabetes and Hypertension: A Cross‐Lagged Model
Authors: Zhu Gangjiao , Malhotra Rahul , Xiong Shangzhi , Chen Xinyue , Gong Enying , Wang Zhan , Østbye Truls , Yan Lijing L. 
Published: January 2025

ABSTRACTThis study aims to evaluate the bidirectional relationship between family functioning and depressive symptoms, considering life satisfaction as a potential mediator and gender, age and income as a moderator of these associations. A longitudinal study was conducted with 708 Chinese adults with diabetes and hypertension (51.6% women; mean age: 64.1 ± 7.7 years) recruited from 12 community health services. Data were collected at baseline (T1), one‐year follow‐up (T2), and two‐year follow‐up (T3) using self‐reported assessments of family functioning, depressive symptoms, and life satisfaction. Depressive symptoms negatively predicted family functioning from T1 to T2, and family functioning negatively predicted depressive symptoms from T2 to T3. Furthermore, life satisfaction mediated the relationship between family functioning and depressive symptoms from T1 to T3, and vice versa. Differences in gender, age, and income showed distinct patterns. Life satisfaction at T2 mediated the effect of family functioning at T1 on depressive symptoms at T3 for men, women, middle‐aged and low‐income adults, whereas life satisfaction mediated the effect of depressive symptoms at T1 on family functioning at T3 only among women and low‐income adults. This study explores the relationships among family functioning, life satisfaction, and depressive symptoms, noting potential differences based on gender, age and income. Family‐level interventions targeting life satisfaction could a helpful approach to addressing depressive symptoms among Chinese adults aged 45 and older with type 2 diabetes and/or hypertension.