bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Regioregular and Random Boron‐Fused Azomethine Conjugated Polymers for Film Morphology Control
Authors: Ohtani Shunsuke , Gon Masayuki , Tanaka Kazuo , Chujo Yoshiki 
Published: February 2024

AbstractRegioregular and random conjugated polymers based on a boron‐fused azomethine unit were synthesized by Sonogashira–Hagihara cross coupling reaction. Although these polymers exhibited similar optical properties in the solution states, a distinct difference was observed in the aggregation forming ability in the film states; scanning electron microscope (SEM) observation indicated the existence of fiber‐like aggregates in the spin‐coated film of the regioregular polymer, while regiorandom polymer showed no aggregate in the film state. Accordingly, the UV–vis absorption spectrum of the regioregular polymer showed an increased shoulder peak due to the aggregate formation, whereas the random one showed no change. Furthermore, an absolute fluorescence quantum efficiency of the regioregular polymer was enhanced in response to the aggregate disassembly via thermal annealing treatment. In this study, we demonstrate that controlling regioregularity of the conjugated polymers can induce the different morphological structures and thermal‐responsive behaviors. These findings could be beneficial for the design strategy and potential applications of thin‐film optoelectronic devices with stimuli‐responsive properties.
Operando DRIFTS Investigations on Surface Intermediates and Effects of Potassium in CO2 Hydrogenation over a K−Fe/YZrOx Catalyst
Authors: Fedorova Elizaveta A. , Kraußer Laura , Weiß Jana , Fedorov Aleksandr , Brückner Angelika , Kondratenko Evgenii V. , Kubis Christoph 
Published: February 2024

AbstractA detailed operando DRIFTS study on the CO2 Fischer‐Tropsch reaction with K‐promoted Fe/YZrOx catalysts was performed to investigate the influence of this modification on the catalytic performance in the formation of lower olefins as well as higher hydrocarbons and to gain insights into mechanistic aspects. Catalytic testing revealed an enhanced formation of olefins and hydrocarbons by adding potassium to the catalysts, while spectroscopic studies revealed various stable adsorbates and intermediates such as monodentate carbonates, bicarbonates, formates, formyl, and methoxy on the surface of the K‐promoted Fe/YZrOx catalysts compared to the unpromoted one. Based on gas‐feed switching experiments and statistical analysis of literature IR data regarding Fe‐containing catalysts, it was found that carbonate species interacting with H2 are transformed to higher hydrocarbons and methane via formate and formyl formation, while bicarbonate species are decomposed accompanied by the formation of CO, which then further reacts to form formate or formyl and finally hydrocarbons.
Synthesis of Bifunctional Catalysts for the Cycloaddition of CO2 to Epoxides through an Epoxide‐Driven Strategy
Authors: Kaewsai Suthida , Del Gobbo Silvano , D'Elia Valerio 
Published: February 2024

AbstractThe design of molecular scaffolds bearing multiple functional groups for the activation and ring‐opening of epoxides is a crucial challenge for the synthesis of efficient homogeneous and heterogeneous catalysts that are used for the cycloaddition reaction of CO2 to epoxides. Traditional approaches to prepare such multifunctional catalysts often imply multistep synthetic procedures and expensive building blocks. In this work we show that bifunctional catalysts for the cycloaddition of CO2 to epoxides bearing a Lewis acid metal and a quaternary ammonium halide group can be prepared in just two steps starting from an opportunely designed epoxide precursor by using inexpensive substrates. Such a readily accessible catalyst was applied for the cycloaddition of CO2 to a series of epoxides under atmospheric conditions generally leading to quantitative substrate conversion and high carbonate selectivities. Importantly, we also show that the epoxide‐driven concept developed for the preparation of the molecular catalyst, could be applied to prepare recyclable heterogeneous systems for the target cycloaddition reaction.
Tuning synergy between nickel and iron in Ruddlesden–Popper perovskites through controllable crystal dimensionalities towards enhanced oxygen‐evolving activity and stability
Authors: Zhang Haijuan , Guan Daqin , Gu Yuxing , Xu Hengyue , Wang Chunchang , Shao Zongping , Guo Youmin 
Published: February 2024

AbstractNi–Fe‐based oxides are among the most promising catalysts developed to date for the bottleneck oxygen evolution reaction (OER) in water electrolysis. However, understanding and mastering the synergy of Ni and Fe remain challenging. Herein, we report that the synergy between Ni and Fe can be tailored by crystal dimensionality of Ni, Fe‐contained Ruddlesden–Popper (RP)‐type perovskites (La0.125Sr0.875)n+1(Ni0.25Fe0.75)nO3n+1 (n = 1, 2, 3), where the material with n = 3 shows the best OER performance in alkaline media. Soft X‐ray absorption spectroscopy spectra before and after OER reveal that the material with n = 3 shows enhanced Ni/Fe–O covalency to boost the electron transfer as compared to those with n = 1 and n = 2. Further experimental investigations demonstrate that the Fe ion is the active site and the Ni ion is the stable site in this system, where such unique synergy reaches the optimum at n = 3. Besides, as n increases, the proportion of unstable rock‐salt layers accordingly decreases and the leaching of ions (especially Sr2+) into the electrolyte is suppressed, which induces a decrease in the leaching of active Fe ions, ultimately leading to enhanced stability. This work provides a new avenue for rational catalyst design through the dimensional strategy.
Self‐supported VO2 on polydopamine‐derived pyroprotein‐based fibers for ultrastable and flexible aqueous zinc‐ion batteries
Authors: Yeon Jeong Seok , Park Sul Ki , Kim Shinik , Mohite Santosh V. , Il Kim Won , Jang Gun , Jang Hyun‐Seok , Bae Jiyoung , Lee Sang Moon , Hong Won G. , Kim Byung Hoon , Kim Yeonho , Park Ho Seok 
Published: February 2024

AbstractA conventional electrode composite for rechargeable zinc‐ion batteries (ZIBs) includes a binder for strong adhesion between the electrode material and the current collector. However, the introduction of a binder leads to electrochemical inactivity and low electrical conductivity, resulting in the decay of the capacity and a low rate capability. We present a binder‐ and conducting agent‐free VO2 composite electrode using in situ polymerization of dopamine on a flexible current collector of pyroprotein‐based fibers. The as‐fabricated composite electrode was used as a substrate for the direct growth of VO2 as a self‐supported form on polydopamine‐derived pyroprotein‐based fibers (pp‐fibers@VO2(B)). It has a high conductivity and flexible nature as a current collector and moderate binding without conventional binders and conducting agents for the VO2(B) cathode. In addition, their electrochemical mechanism was elucidated. Their energy storage is induced by Zn2+/H+ coinsertion during discharging, which can be confirmed by the lattice expansion, the formation of by‐products including Znx(OTf)y(OH)2x−y·nH2O, and the reduction of V4+ to V3+. Furthermore, the assembled Zn//pp‐fibers@VO2(B) pouch cells have excellent flexibility and stable electrochemical performance under various bending states, showing application possibilities for portable and wearable power sources.
Gaucher Disease: A Glance from a Medicinal Chemistry Perspective
Authors: Prencipe Filippo , Barzan Chiara , Savian Chiara , Spalluto Giampiero , Carosati Emanuele , De Amici Marco , Mosconi Giorgio , Gianferrara Teresa , Federico Stephanie , Da Ros Tatiana 
Published: February 2024

AbstractRare diseases are particular pathological conditions affecting a limited number of people and few drugs are known to be effective as therapeutic treatment. Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase, belongs to this class of disorders, and it is considered the most common among the Lysosomal Storage Diseases. The two main therapeutic approaches are the Enzyme Replacement Therapy (ERT) and the Substrate Reduction Therapy (SRT). ERT, consisting in replacing the defective enzyme by administering a recombinant enzyme, is effective in alleviating the visceral symptoms, hallmarks of the most common subtype of the disease whereas it has no effects when symptoms involve CNS, since the recombinant protein is unable to significantly cross the Blood Brain Barrier. The SRT strategy involves inhibiting glucosylceramide synthase (GCS), the enzyme responsible for the production of the associated storage molecule. The rational design of new inhibitors of GCS has been hampered by the lack of either the crystal structure of the enzyme or an in‐silico model of the active site which could provide important information regarding the interactions of potential inhibitors with the target, but, despite this, interesting results have been obtained and are herein reviewed.
Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics
Authors: Sanghai Nitesh , Vuong Billy , Burak Berk Ahmet , Afridi Muhammad Shaharyar K. , Tranmer Geoffrey K. 
Published: February 2024

AbstractNeurodegenerative diseases (NDDs) like Alzheimer's disease (AD), Parkinson's disease (PD), and Amyotrophic lateral sclerosis (ALS) possess multifactorial aetiologies. In recent years, our understanding of the biochemical and molecular pathways across NDDs has increased, however, new advances in small molecule–based therapeutic strategies targeting NDDs are obscure and scarce. Moreover, NDDs have been studied for more than five decades, however, there is a paucity of drugs that can treat NDDs. Further, the highly lipoidal blood–brain barrier (BBB) limits the uptake of many therapeutic molecules into the brain and is a complicating factor in the development of new agents to treat neurodegeneration. Considering the highly complex nature of NDDs, the association of multiple risk factors, and the challenges to overcome the BBB junction, medicinal chemists have developed small organic molecule–based novel approaches to target NDDs over the last few decades, such as designing lipophilic molecules and applying prodrug strategies. Attempts have been made to utilize a multitarget approach to modulate different biochemical molecular pathways involved in NDDs, in addition to, medicinal chemists making better decisions in identifying optimized drug candidates for the central nervous system (CNS) by using web–based computational tools. To increase the clinical success of these drug candidates, an in vitro assay modeling the BBB has been utilized by medicinal chemists in the pre–clinical phase as a further screening measure of small organic molecules. Herein, we examine some of the intriguing strategies taken by medicinal chemists to design small organic molecules to combat NDDs, with the intention of increasing our awareness of neurodegenerative therapeutics.
Oligodeoxynucleotide Synthesis Under Non‐Nucleophilic Deprotection Conditions
Authors: Fang Shiyue , Chillar Komal , Yin Yipeng , Apostle Alexander , Eriyagama Dhananjani N. A. M. , Shahsavari Shahien , Halami Bhaskar , Yuan Yinan 
Published: February 2024

AbstractThis protocol describes a method for the incorporation of sensitive functional groups into oligodeoxynucleotides (ODNs). The nucleophile‐sensitive epigenetic N4‐acetyldeoxycytosine (4acC) DNA modification is used as an example, but other sensitive groups can also be incorporated, e.g., alkyl halide, α‐haloamide, alkyl ester, aryl ester, thioester, and chloropurine groups, all of which are unstable under the basic and nucleophilic deprotection and cleavage conditions used in standard ODN synthesis methods. The method uses a 1,3‐dithian‐2‐yl‐methoxycarbonyl (Dmoc) group that carries a methyl group at the carbon of the methoxy moiety (meDmoc) for the protection of exo‐amines of nucleobases. The growing ODN is anchored to a solid support via a Dmoc linker. With these protecting and linking strategies, ODN deprotection and cleavage are achieved without using any strong bases and nucleophiles. Instead, they can be carried out under nearly neutral non‐nucleophilic oxidative conditions. To increase the length of ODNs that can be synthesized using the meDmoc method, the protocol also describes the synthesis of a PEGylated Dmoc (pDmoc) phosphoramidite. With some of the nucleotides being incorporated with pDmoc‐CE phosphoramidite, the growing ODN on the solid support carries PEG moieties and becomes more soluble, thus enabling longer ODN synthesis. The ODN synthesis method described in this protocol is expected to make many sensitive ODNs that are difficult to synthesize accessible to researchers in multiple areas, such as epigenetics, nanopore sequencing, nucleic acid‐protein interactions, antisense drug development, DNA alkylation carcinogenesis, and DNA nanotechnology. © 2024 Wiley Periodicals LLC.Basic Protocol: Sensitive ODN synthesisSupport Protocol 1: Synthesis of meDmoc‐CE phosphoramiditesSupport Protocol 2: Synthesis of a pDmoc‐CE phosphoramidite
Offloading and adherence through technological advancements: Modern approaches for better foot care in diabetes
Authors: Bus Sicco A. , Reeves Neil D. , Armstrong David G. , Najafi Bijan 
Published: February 2024

AbstractObjectiveThis manuscript aims to provide a review and synthesis of contemporary advancements in footwear, sensor technology for remote monitoring, and digital health, with a focus on improving offloading and measuring and enhancing adherence to offloading in diabetic foot care.MethodsA narrative literature review was conducted by sourcing peer‐reviewed articles, clinical studies, and technological innovations. This paper includes a review of various strategies, from specifically designed footwear, smart insoles and boots to using digital health interventions, which aim to offload plantar pressure and help prevent and manage wounds more effectively by improving the adherence to such offloading.ResultsIn‐house specially made footwear, sensor technologies remotely measuring pressure and weight‐bearing activity, exemplified for example, through applications like smart insoles and SmartBoot, and other digital health technologies, show promise in improving offloading and changing patient behaviour towards improving adherence to offloading and facilitating personalised care. This paper introduces the concept of gamification and emotive visual indicators as novel methods to enhance patient engagement. It further discusses the transformative role of digital health technologies in the modern era.ConclusionsThe integration of technology with footwear and offloading devices offers unparallelled opportunities for improving diabetic foot disease management not only through better offloading but also through improved adherence to offloading. These advancements allow healthcare providers to personalise treatment plans more effectively, thereby promising a major improvement in patient outcomes in diabetic foot ulcer healing and prevention.
Temporal variations of the multifaceted biodiversity and assembly mechanisms in lake fish assemblages
Authors: Liang Zhice , Guo Chuanbo , Gozlan Rodolphe Elie , Park Young‐Seuk , Wen Feng , Kuang Chenyi , Ma Yuxing , Liu Jiashou , Jackson Donald A. 
Published: February 2024

AbstractUnderstanding long‐term changes in fish diversity and community assembly rules is crucial for freshwater conservation. Growing evidence indicates that studying functional and phylogenetic diversity beyond purely taxonomic considerations can provide different but complementary information on community assembly. Here, the taxonomic, functional, and phylogenetic β‐diversity of fish communities, as well as the community assembly mechanisms, were explored in five impounded lakes of the China's South‐to‐North Water Diversion Project (SNWDP) from the 1980s to the 2010s. We found that (1) there was an obvious trend of species homogenization in the five impounded lakes, but the long‐term transformations of different dimensional β‐diversity were divergent; (2) water quality and land use variables have greater impacts on multidimensional β‐diversity; and (3) community assembly process in taxonomic and functional dimensions were dominated by random process in both periods, while shifting from limiting similarity to habitat filtering in the phylogenetic dimension. These results highlight that functional and phylogenetic diversity are important additional ecological indices for assessing the patterns of fish diversity in lakes.
Stir‐cast Al2024‐based composite reinforced with boron carbide and graphene particles: Mechanical and dry sliding wear characteristics
Authors: Vinod Kumar R. , Reddappa H. N. , Chandrashekar A. , Paruti Basavaraju 
Published: February 2024

AbstractBecause of its improved formability, lower production costs, and mechanical properties, aluminum metal matrix composite is the highly intriguing engineering material. It can meet the needs of modern engineering applications used in the automotive, military, aerospace, and marine industries. Hybridization of reinforcement is adopted to develop tailor‐made properties of composites for specific application. In this study, Al‐B4C‐Gr hybrid composites were produced with varying graphene content (0.25, 0.50, 0.75, and 1 wt.%) and keeping boron carbide (10 wt.%) as constant, the effect of graphene proportion on the mechanical properties of produced composites was evaluated. It has been observed that increasing the Gr reinforcement particles in the synthesized composites improves the mechanical characteristics of the composites, such as raising the tensile strength to 215 Mpa and the hardness to 110 HV due to the presence and proper distribution of reinforcement in the matrix. When compared to the base alloy, the tensile strength and hardness of Al10B4C0.75Gr composites rose by 27.174% and 67.290%, respectively. The dry sliding wear behavior of Al‐10 wt.% B4C‐wt.%Gr hybrid composites confirms that graphene and B4C particles in the matrix increase the wear resistance of the produced MMCs. The each parameter such as sliding distance, sliding velocity and load has its influence toward the better wear resistance of the developed composites and were discussed.
An ADO‐OFDM with integrated precoding, companding and optimized power allocation methods for high‐speed data transmission in visible light communication
Authors: S. Swaminathan , N. R. Raajan 
Published: February 2024

AbstractVisible light communications (VLC) has received a lot of attention in recent studies because of its benefits over radio‐frequency (RF) communications. It is a short‐range optical wireless communication system that uses light‐emitting diodes (LEDs) as transmitters. Optical orthogonal frequency division multiplexing (OFDM) is an auspicious technology for VLC high‐speed data transfer. The use of OFDM in a VLC system raises the system's peak‐to‐average power ratio (PAPR). The intrinsic non‐linearity of LED is a key concern in an asymmetrically clipped DC‐biased optical OFDM (ADO‐OFDM) system due to its high PAPR. Also, conventional ADO‐OFDM modulation scheme cannot be used for accommodating different demands of services in downlink multiple access due to the restriction of direct current biased optical OFDM (DCO‐OFDM) and asymmetrically clipped optical (ACO‐OFDM) transmission on odd and even subcarriers. To tackle this issue, a modified ADO‐OFDM (MADO‐OFDM) is proposed that adjusts the numbers of subcarriers required for the transmission of ACO‐OFDM and DCO‐OFDM adaptively based on the requests of services in downlink multiple access. Also, the proposed MADO‐OFDM is integrated with a discrete Hartley Matrix transform (DisHMT) precoder and Generalized Piecewise Linear Compander (GPLD) to provide high‐speed data transmission with less PAPR. In addition, the power is allocated to the proposed MADO‐OFDM system optimally by maximizing the channel capacity based on the Aquila optimizer algorithm. The simulation results reveal that the suggested system's PAPR is reduced by 2.4 dB and 0.8 dB, respectively, compared to conventional ADO and hybrid ADO‐OFDM. It also confirms that the suggested generalized PLC can greatly increase BER without affecting the PAPR performance.
Acrylamide in food products: Formation, technological strategies for mitigation, and future outlook
Authors: Pandiselvam Ravi , Süfer Özge , Özaslan Zeynep Tuğba , Gowda NA Nanje , Pulivarthi Manoj Kumar , Charles Anto Pradeep Raja , Ramesh Bharathi , Ramniwas Seema , Rustagi Sarvesh , Jafari Zahra , Jeevarathinam G. 
Published: February 2024

AbstractThis review examines various methods of reducing acrylamide levels in processed foods, focusing on thermal and nonthermal methods. Acrylamide, which is mainly formed by the Maillard reaction, poses a health risk and therefore requires the implementation of successful mitigation strategies. The processes by which acrylamide is formed, particularly at temperatures above 120°C, such as frying, roasting, and cooking (however, the practical temperature in the inner of foods does not exceed 120°C), serve as a basis for understanding intervention methods. The effectiveness of thermal technologies, including optimization of time and temperature as well as pretreatment and posttreatment techniques, will be studied in detail. In addition, vacuum‐based technologies such as baking, predrying, frying, deep‐frying, and impregnation are examined to shed light on their underlying mechanisms. Advanced thermal techniques such as microwaves and irradiation will be investigated to evaluate their effectiveness in reducing acrylamide. Furthermore, nonthermal methods, including pulsed electric fields, ultrasound treatments, and novel combinations such as pulsed electric fields and blanching, are being investigated. Various enzymatic interventions with asparaginase and glucose oxidase as well as yeast treatments and fermentations offer a wide range of intervention possibilities. The use of additives/coatings and plant extracts, such as edible coatings, polyphenols, and specific ingredient formulations, has shown promise for acrylamide reduction. This paper highlights the commercial implications, future prospects, and barriers to implementation of these methods. By examining different approaches, this comprehensive analysis emphasizes the importance of using different strategies to successfully reduce acrylamide levels in processed foods and provides guidance to the food industry to improve product safety and quality.