bluuebunny/crossref_metadata_2025_split huggingface dataset:
Versatile bubble maneuvering on photopyroelectric slippery surfaces
Authors: Zhan Haiyang , Yuan Zichao , Li Yu , Zhang Liang , Liang Hui , Zhao Yuhui , Wang Zhiguo , Zhao Lei , Feng Shile , Liu Yahua 
Published: October 2023

AbstractContactless bubble manipulation with a high spatiotemporal resolution brings a qualitative leap forward in a variety of applications. Despite considerable advances, light-induced bubble maneuvering remains challenging in terms of robust transportation, splitting and detachment. Here, a photopyroelectric slippery surface (PESS) with a sandwich structure is constructed to achieve the versatile bubble manipulation. Due to the generated dielectric wetting and nonuniform electric field under the irradiation of near infrared (NIR) light, a bubble is subject to both the Laplace force and dielectrophoresis force, enabling a high-efficiency bubble steering. We demonstrate that the splitting, merging and detachment of underwater bubbles can be achieved with high flexibility and precision, high velocity and agile direction maneuverability. We further extend the capability of bubble control to microrobots for cargo transportation, micropart assembly and transmission of gear structures. We envision this robust bubble manipulation strategy on the PESS would provide a valuable platform for various bubble-involved processes, ranging from microfluidic devices to soft robotics.
Electro-capillary peeling of thin films
Authors: Li Peiliu , Huang Xianfu , Zhao Ya-Pu 
Published: October 2023

AbstractThin films are widely-used functional materials that have attracted much interest in academic and industrial applications. With thin films becoming micro/nanoscale, developing a simple and nondestructive peeling method for transferring and reusing the films remains a major challenge. Here, we develop an electro-capillary peeling strategy that achieves thin film detachment by driving liquid to percolate and spread into the bonding layer under electric fields, immensely reducing the deformation and strain of the film compared with traditional methods (reaching 86%). Our approach is evaluated via various applied voltages and films, showing active control characterizations and being appropriate for a broad range of films. Theoretically, electro-capillary peeling is achieved by utilizing the Maxwell stress to compete with the film’s adhesion stress and tension stress. This work shows the great potential of the electro-capillary peeling method to provide a simple way to transfer films and facilitates valid avenues for reusing soft materials.
Transmission-type photonic doping for high-efficiency epsilon-near-zero supercoupling
Authors: Yan Wendi , Zhou Ziheng , Li Hao , Li Yue 
Published: October 2023

AbstractSupercoupling effect is an exotic and counterintuitive physical phenomenon of epsilon-near-zero (ENZ) media, in which the light can be “squeezed” and tunneled through flexible channels substantially narrower than its wavelength. Theoretically, ENZ channels with infinitely small widths perform ideal supercoupling with full energy transmission and zero-phase advance. As a feasible solution to demonstrate ENZ supercoupling through a finite-width channel, photonic doping can assist the light in squeezing, but the resonant dopant introduces inevitable losses. Here, we propose an approach of transmission-type photonic doping to achieve proximate ideal ENZ supercoupling. In contrast to the conventional resonance-type photonic doping, our proposed transmission-type doping replaces high-quality-factor two-dimensional resonant doping modes with low-quality-factor one-dimensional modes, such that obviously high transmission efficiency and zero-phase advance in ENZ supercoupling is achieved and observed in experiments. Benefiting from the high-efficiency ENZ supercoupling, waveguides with near-total energy transmission can be engineered with arbitrary dimensions and shapes, serving as flexible power conduits in the paradigm of waveguide integrated circuits for future millimeter-wave and terahertz integrated circuit innovations.
Facet-engineered TiO2 drives photocatalytic activity and stability of supported noble metal clusters during H2 evolution
Authors: Chen Yufen , Soler Lluís , Cazorla Claudio , Oliveras Jana , Bastús Neus G. , Puntes Víctor F. , Llorca Jordi 
Published: October 2023

AbstractMetal clusters supported on TiO2 are widely used in many photocatalytic applications, including pollution control and production of solar fuels. Besides high photoactivity, stability during the photoreaction is another essential quality of high-performance photocatalysts, however systematic studies on this attribute are absent for metal clusters supported on TiO2. Here we have studied, both experimentally and with first-principles simulation methods, the stability of Pt, Pd and Au clusters prepared by ball milling on nanoshaped anatase nanoparticles preferentially exposing {001} (plates) and {101} (bipyramids) facets during the photogeneration of hydrogen. It is found that Pt/TiO2 exhibits superior stability than Pd/TiO2 and Au/TiO2, and that {001} facet-based photocatalysts always are more stable than their {101} analogous regardless of the considered metal species. The loss of stability associated with cluster sintering, which is facilitated by the transfer of photoexcited carriers from the metal species to the neighbouring Ti and O atoms, most significantly and detrimentally affects the H2-evolution photoactivity.
CRAWLING: a crowdsourcing algorithm on wheels for smart parking
Authors: Garrabé Émiland , Russo Giovanni 
Published: October 2023

AbstractWe present the principled design of CRAWLING: a CRowdsourcing Algorithm on WheeLs for smart parkING. CRAWLING is an in-car service for the routing of connected cars. Specifically, cars equipped with our service are able to crowdsource data from third-parties, including other cars, pedestrians, smart sensors and social media, in order to fulfill a given routing task. CRAWLING relies on a solid control-theoretical formulation and the routes it computes are the solution of an optimal data-driven control problem where cars maximize a reward capturing environmental conditions while tracking some desired behavior. A key feature of our service is that it allows to consider stochastic behaviors, while taking into account streams of heterogeneous data. We propose a stand-alone, general-purpose, architecture of CRAWLING and we show its effectiveness on a set of scenarios aimed at illustrating all the key features of our service. Simulations show that, when cars are equipped with CRAWLING, the service effectively orchestrates the vehicles, making them able to react online to road conditions, minimizing their cost functions. The architecture implementing our service is openly available and modular with the supporting code enabling researchers to build on CRAWLING and to replicate the numerical results.
Deleterious mutations predicted in the sorghum (Sorghum bicolor) Maturity (Ma) and Dwarf (Dw) genes from whole-genome resequencing
Authors: Grant Nathan P. , Toy John J. , Funnell-Harris Deanna L. , Sattler Scott E. 
Published: October 2023

AbstractIn sorghum [Sorghum bicolor (L.) Moench] the Maturity (Ma1, Ma2, Ma3, Ma4, Ma5, Ma6) and Dwarf (Dw1, Dw2, Dw3, Dw4) loci, encode genes controlling flowering time and plant height, respectively, which are critical for designing sorghum ideotypes for a maturity timeframe and a harvest method. Publicly available whole-genome resequencing data from 860 sorghum accessions was analyzed in silico to identify genomic variants at 8 of these loci (Ma1, Ma2, Ma3, Ma5, Ma6, Dw1, Dw2, Dw3) to identify novel loss of function alleles and previously characterized ones in sorghum germplasm. From ~ 33 million SNPs and ~ 4.4 million InDels, 1445 gene variants were identified within these 8 genes then evaluated for predicted effect on the corresponding encoded proteins, which included newly identified mutations (4 nonsense, 15 frameshift, 28 missense). Likewise, most accessions analyzed contained predicted loss of function alleles (425 ma1, 22 ma2, 40 ma3, 74 ma5, 414 ma6, 289 dw1, 268 dw2 and 45 dw3) at multiple loci, but 146 and 463 accessions had no predicted ma or dw mutant alleles, respectively. The ma and dw alleles within these sorghum accessions represent a valuable source for manipulating flowering time and plant height to develop the full range of sorghum types: grain, sweet and forage/biomass.
Inhibition of IL-17 ameliorates keratinocyte-borne cytokine responses in an in vitro model for house-dust-mite triggered atopic dermatitis
Authors: Haertlé Juliane , Kienlin Petra , Begemann Gabriele , Werfel Thomas , Roesner Lennart M. 
Published: October 2023

AbstractA subgroup of patients suffering from atopic dermatitis (AD) does not respond to biologics therapy targeting the key players of type-2 inflammation, and it is an ongoing discussion whether skin-infiltrating Th17 cells may underlie this phenomenon. This study aimed to investigate the potential of allergen-induced, immune-cell derived IL-17 on the induction of inflammatory processes in keratinocytes. Peripheral blood mononuclear cells derived from respectively sensitized AD patients were stimulated with house dust mite (HDM) extract and cell culture supernatants were applied subsequently in absence or presence of secukinumab to primary human keratinocytes. Hereby we confirm that the immune response of sensitized AD patients to HDM contains aside from type-2 cytokines significant amounts of IL-17. Blocking IL-17 efficiently reduced the stimulation-induced changes in keratinocyte gene expression. IL-17-dependent transcriptional changes included increased expression of the cytokines IL-20 and IL-24 as well as Suppressor of Cytokine Siganling 3 (SOCS3), a negative feedback-regulator of the STAT3/IL-17/IL-24 immune response. We conclude that the immune response to HDM can induce pro-inflammatory cytokines from keratinocytes in AD, which in part is mediated via IL-17. Targeting IL-17 may turn out to be a reasonable alternative therapy in a subgroup of patients with moderate to severe AD and HDM sensitization.
Flower electrodes for comfortable dry electroencephalography
Authors: Warsito Indhika Fauzhan , Komosar Milana , Bernhard Maria Anne , Fiedler Patrique , Haueisen Jens 
Published: October 2023

AbstractDry electroencephalography (EEG) electrodes provide rapid, gel-free, and easy EEG preparation, but with limited wearing comfort. We propose a novel dry electrode comprising multiple tilted pins in a flower-like arrangement. The novel Flower electrode increases wearing comfort and contact area while maintaining ease of use. In a study with 20 volunteers, we compare the performance of a novel 64-channel dry Flower electrode cap to a commercial dry Multipin electrode cap in sitting and supine positions. The wearing comfort of the Flower cap was rated as significantly improved both in sitting and supine positions. The channel reliability and average impedances of both electrode systems were comparable. Averaged VEP components showed no considerable differences in global field power amplitude and latency, as well as in signal-to-noise ratio and topography. No considerable differences were found in the power spectral density of the resting state EEGs between 1 and 40 Hz. Overall, our findings provide evidence for equivalent channel reliability and signal characteristics of the compared cap systems in the sitting and supine positions. The reliability, signal quality, and significantly improved wearing comfort of the Flower electrode allow new fields of applications for dry EEG in long-term monitoring, sensitive populations, and recording in supine position.
Minimal amount of exercise prevents incident dementia in cognitively normal older adults with osteoarthritis: a retrospective longitudinal follow-up study
Authors: Chung Yu-Hsuan , Wei Cheng-Yu , Tzeng Ray-Chang , Chiu Pai-Yi 
Published: October 2023

AbstractRobust evidence suggests that regular exercise, including walking more than 6000 steps, is effective for preventing dementia; however, such activity is less feasible in older people with osteoarthritis (OA) or other motor disabilities. Therefore, we aimed to test whether the minimal amount of exercise (MAE) could help prevent dementia in older adults with OA. A retrospective longitudinal study was performed and a non-demented cohort (≥ 50-years-old) of 242 people (155 [64.0%] non-converters and 87 [36.0%] converters) from three centers in Taiwan was analyzed with a mean follow-up of 3.1 (range 0.3–5.9) and 2.9 (range 0.5–6.0) years, respectively. MAE was defined as walking for approximately 15–30 min or 1500–3000 steps. Rate of MAE (0, 1–2, or ≥ 3) within one week were defined as MAE-no, MAE-weekly, or MAE-daily, respectively. The incidence rates of dementia were compared between groups. Multivariate logistic regression and Cox proportional hazards analyses were used to study the influence of MAE on dementia occurrence. Age, education, sex, activities of daily living, neuropsychiatric symptoms, cognition, multiple vascular risk factors, and related medications were adjusted. Compared to the MAE-no group, the odds ratios for the incidents of dementia were 0.48 and 0.19 in the MAE-weekly and MAE-daily groups, respectively. In addition, older age, poorer cognition, poorer ADL performance, and congestive heart failure increased the incidence of dementia. Daily and weekly MAE prevented dementia in older adults with OA. As such, an informative public health policy may help promote adequate exercise in at-risk groups.
Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity
Authors: Jurgelewicz Amanda , Nault Rance , Harkema Jack , Zacharewski Timothy R. , LaPres John J. 
Published: October 2023

Abstract2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with metabolic syndrome (MetS) in humans and elicits pathologies in rodents that resemble non-alcoholic fatty liver disease (NAFLD) in humans through activation of the aryl hydrocarbon receptor (AHR) pathway. Dysregulation of cholesterol homeostasis, an aspect of MetS, is linked to NAFLD pathogenesis. TCDD exposure is also linked to the suppression of genes that encode key cholesterol biosynthesis steps and changes in serum cholesterol levels. In a previous experiment, treating mice with TCDD in the presence of simvastatin, a 3-Hydroxy-3-Methylglutaryl-CoA Reductase competitive inhibitor, altered lipid and glycogen levels, AHR-battery gene expression, and liver injury in male mice compared to TCDD alone. The aim of this study was to deduce a possible mechanism(s) for the metabolic changes and increased injury using single-nuclei RNA sequencing in mouse liver. We demonstrated that co-treated mice experienced wasting and increased AHR activation compared to TCDD alone. Furthermore, relative proportions of cell (sub)types were different between TCDD alone and co-treated mice including important mediators of NAFLD progression like hepatocytes and immune cell populations. Analysis of non-overlapping differentially expressed genes identified several pathways where simvastatin co-treatment significantly impacted TCDD-induced changes, which may explain the differences between treatments. Overall, these results demonstrate a connection between dysregulation of cholesterol homeostasis and toxicant-induced metabolic changes.
Strain-controlled spin transport in a two-dimensional (2D) nanomagnet
Authors: Kumari P. , Rani S. , Kar S. , Kamalakar M. Venkata , Ray S. J. 
Published: October 2023

AbstractSemiconductors with controllable electronic transport coupled with magnetic behaviour, offering programmable spin arrangements present enticing potential for next generation intelligent technologies. Integrating and linking these two properties has been a long standing challenge for material researchers. Recent discoveries in two-dimensional (2D) magnet shows an ability to tune and control the electronic and magnetic phases at ambient temperature. Here, we illustrate controlled spin transport within the magnetic phase of the 2D semiconductor CrOBr and reveal a substantial connection between its magnetic order and charge carriers. First, we systematically analyse the strain-induced electronic behaviour of 2D CrOBr using density functional theory calculations. Our study demonstrates the phase transition from a magnetic semiconductor → half metal → magnetic metal in the material under strain application, creating intriguing spin-resolved conductance with 100% spin polarisation and spin-injection efficiency. Additionally, the spin-polarised current–voltage (I–V) trend displayed conductance variations with high strain-assisted tunability and a peak-to-valley ratio as well as switching efficiency. Our study reveals that CrOBr can exhibit highly anisotropic behaviour with perfect spin filtering, offering new implications for strain engineered magneto-electronic devices.
Lipid metabolism of plasma-derived small extracellular vesicles in COVID-19 convalescent patients
Authors: Xiao Wenjing , Huang Qi , Luo Ping , Tan Xueyun , Xia Hui , Wang Sufei , Sun Yice , Wang Zhihui , Ma Yanling , Zhang Jianchu , Jin Yang 
Published: October 2023

AbstractThe coronavirus disease 2019 (COVID-19), which affects multiple organs, is causing an unprecedented global public health crisis. Most COVID-19 patients recover gradually upon appropriate interventions. Viruses were reported to utilize the small extracellular vesicles (sEVs), containing a cell-specific cargo of proteins, lipids, and nucleic acids, to escape the attack from the host’s immune system. This study aimed to examine the sEVs lipid profile of plasma of recovered COVID-19 patients (RCs). Plasma sEVs were separated from 83 RCs 3 months after discharge without underlying diseases, including 18 recovered asymptomatic patients (RAs), 32 recovered moderate patients (RMs), and 33 recovered severe and critical patients (RSs), and 19 healthy controls (HCs) by Total Exosome Isolation Kit. Lipids were extracted from sEVs and then subjected to targeted liquid chromatography-mass spectrometry. The size, concentration, and distribution of sEVs did not differ in RCs and HCs as validated by transmission electron microscopy, nanoparticle tracking analysis, and immunoblot analysis. Fifteen subclasses of 508 lipids were detected in plasma sEVs from HCs, RAs, RMs, and RSs, such as phosphatidylcholines (PCs) and diacylglycerols (DAGs), etc. Total lipid intensity displayed downregulation in RCs compared with HCs. The relative abundance of DAGs gradually dropped, whereas PCs, lysophosphatidylcholines, and sphingomyelins were higher in RCs relative to HCs, especially in RSs. 88 lipids out of 241 in sEVs of RCs were significantly different and a conspicuous increase was revealed with disease status. The sEVs lipids alternations were found to be significantly correlated with the clinical indices in RCs and HCs, suggesting that the impact of COVID-19 on lipid metabolism lingered for a long time. The lipid abnormalities bore an intimate link with glycerophospholipid metabolism and glycosylphosphatidylinositol anchor biosynthesis. Furthermore, the lipidomic analysis showed that RCs were at higher risk of developing diabetes and sustaining hepatic impairment. The abnormality of immunomodulation in RCs might still exist. The study may offer new insights into the mechanism of organ dysfunction and help identify novel therapeutic targets in the RCs.
M gene targeted qRT-PCR approach for SARS-CoV-2 virus detection
Authors: Sarkar Md. Murshed Hasan , Naser Showti Raheel , Chowdhury Sanjana Fatema , Khan Md. Salim , Habib Md. Ahashan , Akter Shahina , Banu Tanjina Akhtar , Goswami Barna , Jahan Iffat , Nayem Maksudur Rahman , Hassan Md. Akibul , Khan Md. Imran , Rabbi Mohammad Fazle Alam , Ahsan Chowdhury Rafiqul , Miah Md. Ibrahim , Nessa Afzalun , Islam S. M. Rashed Ul , Rahman Mohammed Atiqur , Shaikh Md. Aftab Ali , Ahmed Md. Sharfuddin 
Published: October 2023

AbstractQuantitative reverse transcriptase polymerase chain reaction (qRT-PCR) is the gold standard method for SARS-CoV-2 detection, and several qRT-PCR kits have been established targeting different genes of the virus. Due to the high mutation rate of these genes, false negative results arise thus complicating the interpretation of the diagnosis and increasing the need of alternative targets. In this study, an alternative approach for the detection of SARS-CoV-2 viral RNA targeting the membrane (M) gene of the virus using qRT-PCR was described. Performance evaluation of this newly developed in-house assay against commercial qRT-PCR kits was done using clinical oropharyngeal specimens of COVID-19 positive patients. The limit of detection was determined using successive dilutions of known copies of SARS-CoV-2 pseudovirus. The M gene based assay was able to detect a minimum of 100 copies of virus/mL indicating its capacity to detect low viral load. The assay showed comparable accuracy, sensitivity and specificity with commercially available kits while detecting all the variants efficiently. The study concluded that the in-house M gene based assay might be an effective alternative for the currently available commercial qRT-PCR kits.
Right frontal HD-tDCS reveals causal involvement of time perception networks in temporal processing of concepts
Authors: Johari Karim , Tabari Fatemeh , Desai Rutvik H. 
Published: October 2023

AbstractEvidence suggests that perceptual and action related features of concepts are grounded in the corresponding sensory-motor networks in the human brain. However, less is known about temporal features of event concepts (e.g., a lecture) and whether they are grounded in time perception networks. We examined this question by stimulating the right dorsolateral prefrontal cortex (rDLPFC)—a part of time perception network—using HD-tDCS and subsequently recording EEG while participants performed semantic and time perception tasks. Semantic tasks were composed of event noun duration judgment (EDur), object noun size judgement (OSize), event (EVal) and object noun valence judgement. In the time perception task, participants judged the durations of pure tones. Results showed that cathodal stimulation accelerated responses for time perception task and decreased the magnitude of global field power (GFP) compared to sham stimulation. Semantic tasks results revealed that cathodal, but not sham, stimulation significantly decreased GFP for EDur relative to OSize, and to EVal. These findings provide first causal evidence that temporal features of event words are grounded in the rDLPFC as part of the temporal cognition network and shed light on the conceptual processing of time.