bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship of Online Game Addiction with Aggressive Behavior for Teenagers at SMP Negeri 3 Banyumas
Authors: Adani Amalia Winahyu , Triana Noor Yunida , Murniati Murniati 
Published: February 2024

There is a lot of verbal and physical aggression in online games today. Playing games with a high level of violence can lead to an increase in hostile attitudes and actions. The purpose of this study was to determine whether there is a relationship between online game addiction and the aggressive behavior of grade VIII students at SMP Negeri 3 Banyumas. This study is a correlational study using a cross-sectional approach. The population in this study consisted of 92 grade VIII students of SMP Negeri 3 Banyumas who played online games. A sample of 75 respondents was taken using a simple random sampling technique. The questionnaire was used as a data collector and analyzed with the Spearman rank correlation test. The results showed that most online game addicts were in the mild category (80%), most showed moderate aggressive behavior (62.7%), and there was a strong relationship between online game addiction and aggressive behavior class VIII SMP Negeri 3 Banyumas with a p-value of 0.000 (p-value <0.05; r = 0.579). This indicates that online game addiction can affect a person's aggressive behavior, the higher the level of online game addiction, the more aggressive behavior it leads. This research is expected to be a reference for pediatric nursing.
The Effect of Emergency Response Training on Flood Disaster Preparedness on Student Council Administrators at SMPN 1 Tibawa
Authors: Umar Arifin , Yunus Pipin , Husain Mohammad Ruslan 
Published: February 2024

The effect of emergency response training on flood disaster preparedness on student council administrators at SMPN 1 TIBAWA. Guided by PIPIN YUNUS as chairman and HASLINDA DAMANSYAH as member Disaster emergency response is a series of activities immediately at the time of a disaster to deal with the adverse effects caused. These activities include pre-disaster, during-disaster, and post-disaster. This study aims to determine the effect of emergency response training on flood disaster preparedness in student council administrators at SMPN 1 TIBAWA. This research method uses a quantitative approach with a type of quasi-experimental research with one group. Samples were taken using total sampling techniques, the number of samples was 36 respondents. Data collection using a questionnaire sheet with data analysis using a Paired T-test with meaning (p-value = 0.05). The results showed that there was an average value of preparedness before 46.61 and preparedness after 73.72 there was an increase of 27.11 preparedness values after being given treatment, then the statistical value was obtained p-value = 0.00 smaller than 0.05 (p<0.05). In conclusion, there is an effect of emergency response training on flood disaster preparedness.
Studi Korelasi Kehamilan Usia Remaja dengan Insiden Berat Badan Bayi Lahir Rendah
Authors: Amalia Andi Ega Rizqi , Fauziah Henny , Nurdin Azizah , Rahman Abd. , Sabir Muhammad Sadiq 
Published: February 2024

Latar belakang: World Health Organization (WHO) mendefinisikan Berat Bayi Lahir Rendah (BBLR) merupakan kondisi dimana bayi lahir dengan berat kurang dari 2500 gram. Usia pada saat kehamilan menjadi salah satu faktor dalam kejadian BBLR terkhusus pada usia remaja. Kehamilan pada usia remaja < 20 tahun memiliki risiko medis lebih tinggi yang dapat merugikan bagi kesehatan ibu maupun janin.
Metode: Metode yang digunakan pada penelitian ini yaitu analitik observasional. dengan pendekatan Cross sectional study. Sampel pada penelitian menggunakan rekam medik pasien di Puskesmas Tamangapa dan Puskesmas Jongaya Kota Makassar Tahun 2020-2021 sebanyak 330 sampel.
Hasil: Hasil dari penelitian menunjukkan terdapat hubungan yang signifikan antara kehamilan usia remaja dengan kejadian berat bayi lahir rendah dengan nilai p-value 0.000.
Kesimpulan: Kesimpulan dari penelitian ini terdapat hubungan yang signifikan antara kehamilan usia remaja dengan kejadian berat bayi lahir rendah di Puskesmas Tamangapa dan Puskesmas Jongaya Kota Makassar Tahun 2020-2021.
Malaria Falciparum dengan Trombositopenia Berat: Laporan Kasus di Fasilitas Kesehatan Terbatas
Authors: Semme Muhammad Yatsrib , Widyaningrum Widyaningrum 
Published: February 2024

Latar Belakang:Keadaan trombositopenia berat pada malaria dapat membuyarkan diagnosis. Informasi riwayat perjalanan ke daerah endemis merupakan hal yang sangat penting untuk meningkatkan akurasi diagnosis.
Isi: Laki-laki, 33 tahun, demam 5 hari disertai menggigil dan berkeringat. Tidak membaik dengan paracetamol. Terdapat gejala kuning dan mimisan. Tidak ada riwayat penyakit lain sebelumnya. Suhu axilla 40,4 oC. Uji turniket positif. Kadar trombosit 32x103/µL. Pasien didiagnosis infeksi dengue. Dilakukan transfusi trombosit konsentrat dengan evaluasi CCI. Klinis pasien tidak membaik, diperoleh riwayat perjalanan pasien ke daerah endemis malaria. Pemeriksaan mikroskopis ditemukan trofozoit P. falciparum. Diagnosis dikaji ulang menjadi malaria falciparum. Terapi dilanjutkan dengan DHP dan Primakuin sesuai pedoman. Klinis pasien membaik, evaluasi mikroskopis menjadi negatif dan dinyatakan sembuh.
Kesimpulan: Trombositopenia berat dapat menyertai infeksi malaria. Informasi mengenai riwayat perjalanan ke daerah endemis sangat penting dalam penegakan diagnosis.
Pengaruh Pemberian Madu Hutan Apis dorsata Binghami terhadap Berat Badan Tikus Putih yang Diinduksi Pakan Tinggi Lemak
Authors: Musa Inna Mutmainnah , Abdullah Rezky Putri Indarwati , Usman Musa Muflih 
Published: February 2024

Latar belakang: Kebiasaan mengonsumsi makanan berlemak dapat menyebabkan obesitas yang mengakibatkan berbagai masalah kesehatan. Bahan alami yang dapat menjadi alternatif terapeutik adalah madu. Madu memiliki efek anti-obesitas karena mengandung berbagai senyawa bioaktif. Tujuan penelitian untuk mengetahui pengaruh pemberian Madu Hutan Apis dorsata Binghami terhadap berat badan Tikus putih yang diinduksi pakan tinggi lemak (PTL). Metode: Penelitian bersifat eksperimental dengan desain pre post-test with control group design. 15 ekor tikus jantan Sprague dawley dibagi tiga kelompok, yakni kontrol negatif, kontrol positif yang diinduksi PTL, dan perlakuan yang diinduksi PTL + madu dosis 0,5 ml/200 g BB. Induksi PTL diberikan selama 28 hari dan madu selama 7 hari. Berat badan tikus ditimbang setiap pekan menggunakan timbangan analitik digital. Hasil: Hasilnya tikus kelompok perlakuan mengalami penurunan berat badan yang tidak signifikan (p=0,11). Kesimpulan: Pemberian Madu Hutan Apis dorsata Binghami dosis 0,50 ml/200grBB tidak mempengaruhi penurunan berat badan tikus secara signifikan.
Gambaran Pemetaan Penyebaran Covid-19 Berdasarkan Faktor Risiko Di Kecamatan Kolaka
Authors: Nur Sri Wahyuni , Nasruddin Syam  , Rezky Aulia Yusuf  
Published: February 2024

Coronavirus Disease 2019 (Covid-19) adalah salah satu jenis penyakit menular yang menyerang sistem pernapasan dan dinyatakan sebagai pandemi pada tanggal 12 Maret 2020. Untuk mendeteksi lingkungan yang rentan terhadap penyakit dapat dilakukan dengan menggunakan teknologi penginderaan jauh (remote sensing) dan Geographic Information System (GIS) yang merupakan suatu sistem yang mampu mengolah, memperbaiki, memperbaharui, dan menganalisis data. Jenis penelitian ini adalah penelitian kuantitatif dengan pendekatan deskriptif dan menggunakan Sistem Informasi Geografis (SIG)yang bertujuan untuk mengetahui gambaran pemetaan penyebaran Covid-19 berdasarkan faktor risiko di Kecamatan Kolaka. Sampel dalam penelitian ini adalah kasus terkonfirmasi positif Covid-19 di Kecamatan Kolaka pada bulan Januari-April 2022 yang memiliki data alamat lengkap. Metode analisis data pada penelitian ini yaitu analisis univariat dan analisis spasial. Hasil penelitian menunjukkan penyebaran Covid-19 di Kecamatan Kolaka berdasarkan faktor risiko umur dengan kategori umur 26-45 tahun, sebagian besar masyarakat yang terpapar Covid-19 belum menerima vaksin lengkap, penyakit penyerta yang paling banyak diderita yaitu hipertensi, dan tempat yang paling sering dikunjungi adalah sarana ibadah.
Tingkat Kecemasan Ibu Menyusui Di Masa Pandemi Covid-19 Di Desa Manurung Kecamatan Malili Kabupaten Luwu Timur
Authors: Marlina  , Yusriani  , Fairus Prihatin Idris  
Published: February 2024

Corona Virus Disease 2019 (COVID-19) telah masuk di Indonesia Pandemi covid-19 merupakan wabah yang terjadi diseluruh dunia termasuk di indonesia. Sehingga menimbulkan masalah kesehatan mental yang terjadi ini yaitu meningkatan tingkat stres dan kecemasan di berbagai daerah Khususnya di Desa Manurung Kecamatan Malili Kabupaten Luwu Timur Provinsi Sulawesi Selatan yang menempati posisi pertama sebanyak 385 kasus. Tujuan penelitian ini adalah untuk mengetahui tingkat Kecemasan ibu menyusui pada masa pandemi Covid-19. Jenis penelitian yang digunakan ini adalah penelitian kuantitatif dengan pendekatan deskriptif . Instrument yang digunakan adalah kuesioner. Populasi dalam penelitian ini adalah ibu menyusui berjumlah 72 jiwa. Sampel yang ada pada penelitian ini sebanyak 72 responden ibu menyusui di Desa Manurung Kecamatan Malili Kabupaten Luwu Timur Provinsi Sulawesi Selatan.Hasil penelitian ini menujukkan bahwa kecemasan ibu menyusui di masa pandemi Covid-19 adalah sebanyak 52,8% yang mengalami kecemasan dan yang mengalami tidak cemas seabnyak 47,2% di Desa Manurung Kecamatan Malili Kabupaten Luwu Timur Provinsi Sulawesi Selatan.Dari hasil penelitian ini menyarankan untuk ibu menyusui meningkatkan pemahaman terkait tingkat kecemasan ibu pada masa pandemi covid-19.
Aplikacja mobilna SafeTy jako narzędzie poprawy bezpieczeństwa w środowisku lokalnym
Authors: Dobrowolski Filip 
Published: February 2024

W wyniku pandemii COVID-19 nastąpił jeszcze większy wzrost wykorzystania nowych technologii w codziennym życiu mieszkańców miast, a w szczególności środków komunikacji na odległość, w tym aplikacji mobilnych. W kontekście występowania różnego rodzaju zagrożeń bezpieczeństwa i porządku publicznego, szybki dostęp do informacji nabiera kluczowego znaczenia. Ma to z kolei wpływ zarówno na cele, jak i sposoby realizacji polityki bezpieczeństwa nie tylko w skali makro, ale przede wszystkim w skali mikro - na obszarze gmin, miast, dzielnic czy osiedli, a więc w bezpośrednim otoczeniu mieszkańców. Zapobieganie takim problemom publicznym jak przestępstwa i wykroczenia, niewątpliwie wymaga zaangażowania nie tylko państwa i jego organów, ale także społeczeństwa, co jest jednym z podstawowych założeń strategii community policing. Natomiast wprowadzanie nowoczesnych rozwiązań w celu poprawy jakości życia mieszkańców stanowi podstawę takich koncepcji jak smart city czy resilient city. Narzędziem, które łączy w sobie elementy wymienionych koncepcji są tzw. „partycypacyjne mapy przestępczości”, dzięki którym mieszkańcy otrzymują nie tylko dane statystyczne, ale także możliwość wzajemnego informowania się o zagrożeniach występujących w ich okolicy, co z kolei ma prowadzić do wzmocnienia więzi społecznych. Mapowanie zagrożeń pozwala również na lepszą identyfikację występujących problemów oraz podejmowanie wielopodmiotowej współpracy w zakresie ich zwalczania. W artykule podjęta została próba odpowiedzi na pytanie w jaki sposób aplikacja mobilna może zostać wykorzystana do poprawy bezpieczeństwa w środowisku lokalnym?
Zaspokojenie potrzeb konsumentów usług turystycznych w miastach poprzemysłowych - obiekty Szlaku Zabytków Techniki Województwa Śląskiego
Authors: Suchecki Kajetan 
Published: February 2024

Szlak Zabytków Techniki Województwa Śląskiego to szlak kulturowy składający się z kilkudziesięciu obiektów rozrzuconych po całym województwie. Jego funkcjonowanie, wynikające z założeń strategicznych władz województwa śląskiego, napędza ruch turystyczny w obiektach będących jego częścią, działających także na zasadach komercyjnych, co przekłada się na zainteresowanie turystyką w regionie, w tym konieczność korzystania przez turystów – konsumentów z produktów oferowanych w ramach oferty województwa śląskiego. Celem pracy, to jest oceny podaży towarów i usług oferowanych na opisywanym szlaku kulturowym oraz jej relacji z potrzebami – popytem, jaki zgłaszają konsumenci. Stopień realizacji tych potrzeb został przebadany w trakcie badań bezpośrednich na Szlaku Zabytków Techniki. Badanie odbyło się w okresie maj – sierpień 2019 roku w formie wywiadu bezpośredniego z konsumentami odwiedzającymi kilka wybranych obiektów Szlaku. Stopień realizacji zgłaszanych potrzeb oraz poziom dostępności do towarów i usług na Szlaku Zabytków Techniki zostały w znacznej mierze ocenione przynajmniej jako wystarczające. Niektóre z nich wymagają jeszcze poprawy, co może być drogowskazem z jednej strony dla samorządowców Górnośląsko-Zagłębiowskiej Metropolii, a z drugiej strony dla przedsiębiorców oferujących swoje produkty w pobliżu obiektów Szlaku Zabytków Techniki.
Proanthocyanidins isolated from the leaves of Ficus glomerata evaluated on the activities of rumen enzymes: in vitro and in silico studies
Authors: Lata Suman , Koli Pushpendra , Singh Sultan , Bhadoria Brijesh Kumar , Chand Umesh , Yadav Dinesh Kumar , Al-Shuwaili Thamer , Ren Yonglin 
Published: February 2024

Two new proanthocyanidins (2S:3S)-(−)-epicatechin-(4α→8)4-(2R:3R)-(+)-catechin (Compound 1) and (2R, 3R)-3-O-galloyl-(+)-catechin (4β→8)3-(2R, 3R)-3-O-galloyl-(+)-catechin (Compound 2) were isolated from Ficus glomerata and characterized by ultraviolet spectroscopy (UV), proton nuclear magnetic resonance (1H NMR), 13C NMR, and heteronuclear multiple bond correlation . The bioactivity and drug scores of isolated compounds were predicted using OSIRIS property explorer applications with drug scores of 0.03 (compound 1) and 0.05 (compound 2). Predictive drug scores provided an indication of the compounds’ potential to demonstrate desired biological effects. Furthermore, the newly discovered proanthocyanidins tended to interact with protein due to their chemical structure and molecular conformation. With the aim of maintaining this focus, compounds 1 and 2 were subjected to in vitro testing against ruminal enzymes to further explore their potential impact. Both compounds showed significant inhibition activities (p &lt; 0.01) against glutamic oxaloacetic transaminase in both protozoa and bacterial fractions, with an effective concentration (EC50) of 12.30–18.20 mg/mL. The compounds also exhibited significant inhibition (p &lt; 0.01) of ruminal glutamic pyruvic transaminase activity, with EC50 values ranging from 9.77 to 17.38 mg/mL. Furthermore, the inhibition was recorded in R-cellulase between EC50 values of 15.85 and 23.99 mg/mL by both compounds. Additionally, both compounds led to a decrease in protease activity with increasing incubation time and concentration. In conclusion, the results indicate that these novel proanthocyanidins hold the potential to significantly impact rumen enzyme biology. Furthermore, their promising effects suggest that they could be further explored for drug development and other important applications.
Proppant distribution characteristics based on the coring well analysis
Authors: Wang Tao , Zhang Jizhuo , Xiang Yuankai , Tang Wei , Yin Shitan , Ye Yiping , Shi Shanzhi , Li Yi 
Published: February 2024

It is significant to clarify the proppant distribution pattern under real fracturing conditions to optimize the sand addition process in hydraulic fracturing of the Mahu tight conglomerate reservoir. However, the laboratory experiment is far from the real fracturing condition due to the limitations of scale, pumping scale, and stress conditions. In this paper, the proppant in cuttings and mud was obtained by screening and cleaning samples from the high-deviated coring well of the Mahu conglomerate reservoir in Xinjiang. The sphericity of particles was observed by a continuous variable magnification microscope, and the transparency (TR) of particles and the red-blue difference (RBD) of reflected light were followed by transmitted light. Considering these three factors, the proppant identification method in cuttings was established to obtain the spatial location and distribution of proppant along the whole well section. The effect of proppant transport and placement was evaluated. The results show that: (1) Compared with the formation of mineral particles, the proppant has better sphericity, TR&gt;20%, and RBD &gt; 30. Combined with the surface roughness, luster, and associated minerals, the particle can be evaluated as a proppant. (2) The content of proppant with small particle size (40/70 mesh) is significantly higher than that with large particle size (20/40 mesh), which ranges from 10‰ to 450‰ and 5‰ to 280‰, respectively. (3) Horizontally, 20/40 mesh proppant migrates approximately 10m, and 40/70 mesh proppant migrates approximately 23 m in the hydraulic fracture. (4) In the longitudinal fracture, 20/40 mesh proppant was concentrated at a 12 m vertical distance from the adjacent well, while 40/70 mesh proppant was placed at a larger longitudinal range, approximately 10 m above and 10 m below the adjacent well. The research results have certain reference significance for the improvement measures of the sand-adding process in the Mahu tight conglomerate reservoir.
Sustained silencing peanut allergy by xanthopurpurin is associated with suppression of peripheral and bone marrow IgE-producing B cell
Authors: Yang Nan , Srivastava Kamal , Chen Yujuan , Li Hang , Maskey Anish , Yoo Patrick , Liu Xiaohong , Tiwari Raj K. , Geliebter Jan , Nowak-Wegrzyn Anna , Zhan Jixun , Li Xiu-Min 
Published: February 2024

IntroductionPeanut allergy is an immunoglobulin E (IgE) mediated food allergy. Rubia cordifolia L. (R. cordifolia), a Chinese herbal medicine, protects against peanut-induced anaphylaxis by suppressing IgE production in vivo. This study aims to identify IgE-inhibitory compounds from the water extract of R. cordifolia and investigate the underlying mechanisms using in vitro and in vivo models.MethodsCompounds were isolated from R. cordifolia water extract and their bioactivity on IgE production was assessed using a human myeloma U266 cell line. The purified active compound, xanthopurpurin (XPP), was identified by LC-MS and NMR. Peanut-allergic C3H/HeJ mice were orally administered with or without XPP at 200µg or 400µg per mouse per day for 4 weeks. Serum peanut-specific IgE levels, symptom scores, body temperatures, and plasma histamine levels were measured at challenge. Cytokines in splenocyte cultures were determined by ELISA, and IgE + B cells were analyzed by flow cytometry. Acute and sub-chronic toxicity were evaluated. IL-4 promoter DNA methylation, RNA-Seq, and qPCR analysis were performed to determine the regulatory mechanisms of XPP.ResultsXPP significantly and dose-dependently suppressed the IgE production in U266 cells. XPP significantly reduced peanut-specific IgE (&gt;80%, p &lt;0.01), and plasma histamine levels and protected the mice against peanut-allergic reactions in both early and late treatment experiments (p &lt; 0.05, n=9). XPP showed a strong protective effect even 5 weeks after discontinuing the treatment. XPP significantly reduced the IL-4 level without affecting IgG or IgA and IFN-γ production. Flow cytometry data showed that XPP reduced peripheral and bone marrow IgE + B cells compared to the untreated group. XPP increased IL-4 promoter methylation. RNA-Seq and RT-PCR experiments revealed that XPP regulated the gene expression of CCND1, DUSP4, SDC1, ETS1, PTPRC, and IL6R, which are related to plasma cell IgE production. All safety testing results were in the normal range.ConclusionsXPP successfully protected peanut-allergic mice against peanut anaphylaxis by suppressing IgE production. XPP suppresses murine IgE-producing B cell numbers and inhibits IgE production and associated genes in human plasma cells. XPP may be a potential therapy for IgE-mediated food allergy.
Effects of a music therapy and music listening intervention for nursing home residents with dementia: a randomized controlled trial
Authors: Prick Anna-Eva J. C. , Zuidema Sytse U. , van Domburg Peter , Verboon Peter , Vink Annemieke C. , Schols Jos M. G. A. , van Hooren Susan 
Published: February 2024

IntroductionThe aim of the present study was to evaluate the effects of an individual music therapy intervention and an individual music listening intervention on neuropsychiatric symptoms and quality of life in people with dementia living in a nursing home and on professional caregiver’s burden to be able to make statements about their specific value of application in clinical practice.MethodsA multicenter single blind randomized controlled trial with three groups was performed: an individual music therapy intervention (IMTI) group (n = 49), an individual music listening intervention (IMLI) group (n = 56) and a control group (n = 53) receiving usual care. The interventions were given during three weeks, three times a week on non-consecutive days during 30–45 minutes for in total nine sessions. The endpoint of the study is the difference from baseline to interim (1,5 week), post-intervention (3 weeks) and follow-up (6 weeks) in reported scores of problem behaviour (NPI-NH) and quality of life (Qualidem) in people with dementia and occupational disruptiveness (NPI-NH) in care professionals.ResultsIn total 158 people with dementia were randomized to one of the two intervention groups or the control group. Multilevel analyses demonstrated that hyperactive behaviour assessed by the NPI-NH was significantly more reduced for the IMLI group at follow up and that restless behaviour assessed by the Qualidem was significantly more reduced for the IMTI group at post and follow-up measurement compared to the control group. No significant effects between groups were found in other NPI-NH clusters or Qualidem subscales.ConclusionIn conclusion, because we found no convincing evidence that the IMTI or IMLI is more effective than the other both interventions should be considered in clinical practice. For the future, we advise further research into the sustainability of the effects with alternative designs, like a single case experimental design.
Assessing the association between age at first sexual intercourse and migraine: a Mendelian randomization study
Authors: Zhu Guoliang , Wang Miao , Wang Yawen , Kong Fanyi 
Published: February 2024

Background and objectivesAs indicated by observational and genetic variation studies, age at first sexual intercourse (AFS) may be associated with migraine attack, but there is a lack of evidence from real-world studies due to ethical concerns. Therefore, we conducted a Mendelian randomization study to determine the causal relationship between AFS and migraine.MethodsWe extracted instrumental variables from summary data of a genome-wide association study (GWAS) on AFS and migraine and then conducted two-sample Mendelian randomization analyses. GWAS data for AFS and migraine were obtained from 397,338 unrelated individuals (214,547 females and 182,791 males) and 306,314 individuals (18,477 patients and 287,837 control individuals), respectively.ResultsThere was a causal relationship between AFS and risk for migraine (odds ratio (OR) = 0.73, 95% confidence interval (CI) [0.61 to 0.86]), both for migraine with aura (MWA; OR = 0.72, 95% CI [0.58 to 0.89]) and migraine without aura (MOA; OR = 0.66, 95% CI [0.51 to 0.86]). Stratified analyses provided suggestive evidence of the causal relationship between delayed AFS and a decreased risk of migraine for both males (OR = 0.71, 95% CI [0.59 to 0.84]) and females (OR = 0.73, 95% CI [0.61 to 0.89]). Reverse Mendelian randomization did not reveal any effect of migraine on AFS (p &gt; 0.05). No pleiotropy was detected.DiscussionA delayed AFS is a protective factor against migraine (for both MWA and MOA) in both males and females. This causal relationship indicates the presence of extracranial regulatory pathways of migraine.