bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synovial biomarkers in the diagnosis of post-traumatic osteoarthritis following anterior cruciate ligament and meniscus injuries: protocol for a systematic review
Authors: Oliveira João Pedro , Mendes João Castro , Casanova José , Fonseca Fernando , Ferreira Mendes Alexandrina , Donato Helena 
Published: January 2025

IntroductionThis review aims to synthesise research evidence regarding biomarkers in the synovial fluid that may predict the risk of post-traumatic osteoarthritis (PTOA) in young adults. Considering the high prevalence of knee joint injuries, particularly among youth sports athletes, this review will focus on anterior cruciate ligament and/or meniscal ruptures. These injuries are highly associated with PTOA, with studies indicating that even with surgical reconstruction, 50%–80% of affected individuals develop knee PTOA within a 10-year follow-up.Methods and analysisThe results of this systematic review will be reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Diagnostic Test Accuracy guidelines. Comprehensive electronic searches will be conducted across five platforms: four bibliographic databases (PubMed, Cochrane Central Register of Controlled Trials, Web of Science Core Collection and Embase) and ClinicalTrials.gov registry. These searches will use combinations of predefined keywords, such as “knee”, “synovial fluid”, “post-traumatic osteoarthritis”, “anterior cruciate ligament”, “meniscus”, “trauma”, “inflammation” and “biomarker”. We will include randomised clinical trials, non-randomised prospective or retrospective clinical studies, case controls, cohort studies and case series, ranging from database inception to 30 June 2024 and published in English. Two independent reviewers will screen and evaluate the retrieved studies to determine their eligibility. Any reviewer disagreements will be resolved through discussion and consensus or, if necessary, by consultation with a third reviewer. The data will be extracted from the included studies and analysed, with the risk of bias assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. A narrative synthesis will be performed to evaluate the strength and consistency of the findings, considering both the methodological quality of the included studies and the reliability of the results.Ethics and disseminationEthical approval is not required for this review as it is a secondary study based on public and published data. The findings from this work will be submitted for publication in a peer-reviewed journal and presented at relevant academic conferences. Any amendments to the protocol arising from deviations during the study’s execution will be documented and reported in the final publication.PROSPERO registration numberCRD42024534272.
Developing a set of key principles for care planning within older adult care homes: study protocol for a modified Delphi survey
Authors: Taylor Jonathan , Caprioli Thais , Damant Jacqueline , Hamashima Yuri , Jasim Sarah , Smith Nick , Toma Madalina 
Published: January 2025

BackgroundOlder adult care homes in England are required to develop care plans on behalf of each of their residents and to make these documents available to those who provide care. However, there is a lack of formal agreement around the key principles that should inform the development of care plans in care homes for older adults. Using a modified Delphi survey, we intend to generate consensus on a set of key principles that should inform the care planning process.Methods and analysisA two-stage modified Delphi survey will be used to try to reach a consensus on a set of key principles to inform care planning within older adult care homes in England. An interdisciplinary panel of approximately 50 people with experience in care planning will be convened and invited to provide feedback on a set of key principles. We will use an iterative, quasi-anonymous, multistage approach with controlled feedback. In the first round, panellists will be asked to provide feedback on a draft document whose contents have been informed by a systematic scoping review and consultations with care home staff. The first round will be administered and subsequently analysed. The results from the first round will be fed back to the panel members and panellists will be asked to complete a second survey. In each round, panel members will use a 5-point unipolar scale to rate their agreement with the item. Consensus will be considered if ≥75% of participants rate an item as 4–5.Ethics and disseminationThis study to which this protocol relates has been granted ethical approval by the University of Kent’s Division for the Study of Law, Society and Social Justice Research Committee Ethics Panel (reference: 1006) on 9 April 2024. The results of this project will be disseminated through conferences and one or more peer-reviewed journals. In a subsequent research phase, the research team plans to share the key principles document developed through this modified Delphi survey with care home residents and their families and friends. We plan to invite their feedback through a series of focus groups with a view to developing a related document for the family and friends of care home residents.
Barriers and enablers encountered by bereaved informal motor neuron disease (MND) caregivers when trying to access bereavement support: a qualitative cross-sectional thematic analysis of semistructured interviews with 6–36 months postbereavement informal MND caregivers in the UK
Authors: Braben Liberty , Khatiwada Deepsi , Cramond Laura , Bradley Belinda F , Chhetri Suresh K. 
Published: January 2025

BackgroundCaregivers of people with motor neuron disease (MND) face more negative consequences of caregiving than other terminal illnesses. The impact of this caregiver burden can negatively influence bereavement outcomes.ObjectivesThis study aims to explore the support needs of caregivers of people with MND, the types of bereavement services they use, or the reasons for not using bereavement services, and understanding the opportunities and barriers to accessing bereavement services.DesignThe design of the study was a qualitative interview study using thematic analysis following the method of Braun and Clarke (2006).Setting and participantsTwenty bereaved caregivers of people with MND were purposively sampled. Participants were recruited through the Lancashire and South Cumbria MND Care and Research Centre.ResultsThematic analysis revealed four overarching themes: (1) type of support accessed, (2) the importance of people who understand, (3) barriers to accessing support, and (4) being (un)prepared for death and afterwards.ConclusionsCaregivers of people with MND require people who understand their unique needs to support them, alongside professional support, to prepare them for the death of their loved one and beyond. Barriers to accessing support included the need for in-person support, insufficient financial support or signposting to relevant services and being unprepared for death and bereavement.
Clinicopathological and prognostic significance of the microcystic elongated and fragmented pattern in endometrial cancer: a systematic review and meta-analysis
Authors: Jia Peng , Duan Baofeng , Zhang Yan 
Published: January 2025

ObjectiveThe presence of the microcystic elongated and fragmented (MELF) pattern, distinguished by its microcystic, elongated and fragmented attributes, constitutes a common manifestation of myometrial invasion (MI) within endometrial carcinoma. However, the prognostic significance of this pattern has not been definitively established. Consequently, this research aimed to clarify the prognostic implications of the MELF pattern for individuals diagnosed with endometrial carcinoma.DesignSystematic review and meta-analysis of observational clinical studies.Data sourcesAn extensive review of the literature was conducted using reputable databases such as PubMed, Embase, Web of Science and the Cochrane Library, covering the period from January 2003 to October 2023. Search terms encompassed endometrial cancer and the MELF pattern.Eligibility criteria for selecting studiesThe inclusion criteria were patients who had undergone hysterectomy and whose pathology confirmed endometrial endometrioid carcinoma, with or without MELF infiltration.Data extraction and synthesisTwo reviewers performed data extraction separately. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS). Stata V.17.0 software was used for statistical analysis.ResultsThe meta-analysis incorporated 16 retrospective cohort studies. Employing a fixed-effects approach, the analysis demonstrated an association of the MELF pattern with reduced overall survival (HR 2.21, 95% CI 1.50–3.25, p=0.000) and lower disease-free survival rates among patients with endometrial cancer (HR 1.72, 95% CI 1.17 to 2.55, p=0.006). Furthermore, aggregated data revealed a linkage between the MELF pattern and significant MI, nodal metastasis, involvement of the lymphovascular space, penetration of the cervical stroma and progression to advanced stages of endometrial carcinoma.ConclusionThe MELF pattern serves as a significant adverse prognostic factor in endometrial cancer, warranting increased attention.
Prevalence of chronic kidney disease in Western Australia, 2010–2020
Authors: Mehta Kanika , Randall Sean , Lee Crystal Man Ying , Thomas Elizabeth , Chakera Aron , Chai Kevin , Estai Mohamed , Frith Madison , Hendrie Delia , Boyd James , Robinson Suzanne 
Published: January 2025

ObjectiveTo assess the prevalence and trends of chronic kidney disease (CKD) in Western Australia (WA) from 2010 to 2020 using linked pathology data.DesignA retrospective observational cohort study using linked de-identified data from WA pathology providers, hospital morbidity records and mortality records.SettingA Western Australian population-based study.ParticipantsAll individuals aged 18 years and older with at least one serum creatinine test.Primary outcome measureCKD status as determined by estimated glomerular filtration rate and urine albumin-creatinine ratio.ResultsAnalysing data from 2 501 188 individuals, there was a significant increase in age-sex standardised CKD prevalence from 4.7% in 2010 to 6.0% in 2020, with annual average percentage change of 3.0% (95% CI: 2.3% to 3.7%). Prevalence of CKD stages 3 and above was 4.8% in 2020. Higher CKD prevalence was observed in regional and remote areas compared with major cities, and among individuals in the most socioeconomically disadvantaged quintiles. Sensitivity analysis indicated minor impacts from data exclusions and methodological choices.ConclusionsCKD prevalence in WA has been steadily increasing, reflecting broader Australian trends. The study highlights significant disparities in CKD prevalence based on age, socioeconomic status and geographic remoteness.
Widening access to isotretinoin in primary care: an evaluation of New Zealand national dispensing data for isotretinoin for acne, 2008–2023
Authors: Moodie Peter , Roskvist Rachel Petronella , Arnold Jason , Quinlin Diarmuid , Arroll Bruce 
Published: January 2025

ObjectivesTo identify what changes in the prescribing of isotretinoin have occurred since funded prescriber access was widened in 2009 from ‘dermatologist only’ prescribing to include ‘general practitioners (GPs) and nurse practitioners working within their scope of practice’.DesignEvaluation of isotretinoin dispensing data from 2008 to 2023 using the national annual prescribing data obtained from the New Zealand Pharmaceutical National Collection database.SettingAll New Zealand citizens prescribed and dispensed funded isotretinoin for acne from 2008 to 2023 were included.Main outcome measuresThe prescribing data were analysed to identify the total number of prescriptions per year by prescribing clinician type, patient ethnicity and deprivation levels.ResultsIn 2008, nearly 100% (26 897) of dispensed prescriptions were written by a dermatologist, while in 2023, 79% (39 432) were written by primary care clinicians. Annual isotretinoin prescriptions increased by 87%, from 26 897 (2008) to 50 613 (2023). Prescriptions for Māori increased from 1750 in 2008 to 4374 in 2023, with similar increases for other ethnic minorities.ConclusionExpanding the prescriber cohort has resulted in a substantial increase in prescriptions, with primary care now issuing the majority of isotretinoin prescriptions. These data demonstrate that the GP workforce can absorb and manage the additional acne workload from the increasing population. Enhanced access for patients suggests an unmet need. An absolute number of prescriptions have risen faster for Māori and Asian patients than for Europeans. Pacific people were generally lower than Europeans. This suggests the longstanding ethnic disparity in access to isotretinoin is partially reduced.Many countries have restrictions on patient access to isotretinoin, similar to New Zealand in 2008. This is the first study demonstrating that, given appropriate postgraduate education and support, the isotretinoin risk–benefit profile may be enhanced to safely deliver high-quality, timely, equitable patient access to isotretinoin in primary care.
Global estimates of prevalence of chronic painful neuropathy among patients with chemotherapy-induced peripheral neuropathy: systematic review and meta-analysis of data from 28 countries, 2000–24
Authors: D'Souza Ryan S , Saini Chandan , Hussain Nasir , Javed Saba , Prokop Larry , Her Yeng F 
Published: January 2025

IntroductionAlthough the prevalence of chemotherapy-induced peripheral neuropathy (CIPN) has been reported, the proportion of patients with CIPN who report chronic painful neuropathy remains poorly understood, despite its significant impact on patients' quality of life and treatment outcomes.MethodsA systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary outcome was the pooled prevalence of chronic (≥3 months) painful CIPN among patients diagnosed with CIPN. Estimates from each study were transformed using double arcsine transformation and pooled in a meta-analysis using an inverse variance heterogeneity model. Subgroup analysis was conducted based on geographical region, sex, chemotherapy regimen, primary cancer type, and funding source; meta-regression analysis was conducted based on study design, human development index (HDI), and publication year.Results77 studies from 28 countries, encompassing 10 962 patients with CIPN, were included. Among patients diagnosed with CIPN, the pooled prevalence of those reporting chronic painful CIPN was estimated at 41.22% (95% CI 32.40 to 50.19; 95% prediction interval 23.71 to 61.28). Substantial heterogeneity was observed across studies (I²=95.27%; 95% CI forI294.58 to 95.86). Subgroup analysis revealed that patients treated with platinum based agents and taxanes had the highest prevalence of chronic painful CIPN (40.44% and 38.35%, respectively), and among primary cancers, those with lung cancer reported the highest prevalence of chronic painful CIPN (60.26%). Study design, HDI, and publication year were non-significant moderators of prevalence estimates. Based on our GRADE (Grading of Recommendations, Assessment, Development and Evaluation) assessment, the certainty of evidence was considered very low.ConclusionThis study provides the first comprehensive global estimate of the prevalence of chronic painful CIPN, highlighting its significant burden on patients worldwide. The variation in prevalence across geographical regions, chemotherapy regimens, and primary cancers underscores the need for tailored pain management strategies and further research to address potential disparities.Trial registrationPROSPERO CRD42024579459.
The Felsenkeller shallow-underground laboratory for nuclear astrophysics
Authors: Bemmerer Daniel , Boeltzig Axel , Grieger Marcel , Gudat Katharina , Hensel Thomas , Masha Eliana , Osswald Max , Poser Bruno , Rümmler Simon , Schmidt Konrad , Taín José Luis , Tarifeño-Saldivia Ariel , Turkat Steffen , Yadav Anup , Zuber Kai 
Published: January 2025

Abstract
In the Felsenkeller shallow-underground site, protected from cosmic muons by a 45 m thick rock overburden, a research laboratory including a 5 MV Pelletron ion accelerator and a number of radioactivity-measurement setups is located. The laboratory and its installations are described in detail. The background radiation has been studied, finding suppression factors of 40 for cosmic-ray muons, 200 for ambient neutrons, and 100 for the background in germanium

$$\gamma $$

γ

-ray detectors. Using an additional active muon veto, typically the background is just twice as high as in very deep underground laboratories. The properties of the accelerator including its external and internal ion sources and beam line are given. For the radioactivity counting setup, detection limits in the 10

$$^{-4}$$

-
4

Bq range have been obtained. Practical aspects for the usage of the laboratory by outside scientific users are discussed.
Maximum-utility popular matchings with bounded instability
Authors: Schlotter Ildikó , Cseh Agnes 
Published: January 2025

In a graph where vertices have preferences over their neighbors, a matching is called popular if it does not lose a head-to-head election against any other matching when the vertices vote between the matchings. Popular matchings can be seen as an intermediate category between stable matchings and maximum-size matchings. In this paper, we aim to maximize the utility of a matching that is popular but admits only a few blocking edges.
We observe that for general graphs finding a popular matching with at most one blocking edge is already NP-complete. For bipartite instances, we study the problem of finding a maximum-utility popular matching with a bound on the number (or more generally, the cost) of blocking edges applying a multivariate approach. We show classical and parameterized hardness results for severely restricted instances. By contrast, we design an algorithm for instances where preferences on one side admit a master list, and show that this algorithm is roughly optimal.
One Step Synthesis of Carbon Nitride/Carbon Nanotube Composite Nanomaterials Modified Electrode for Sensitive Electrochemical Detection of Bisphenol A
Authors: Sun Yanhua , Niu Maowen , Bai Yanwei , Zhang Jianbao , Fu Jiahui , Fang Shijie , Liu Wei , Liu Lei , Wang Wei 
Published: January 2025

In this work, RCN/WCNTs nanocomposites were synthesized using a one-step method and characterized using SEM, XPS, FTIR. An electrochemical sensor capable of sensitive and rapid detection of BPA was developed by modifying RCN/WCNTs nanocomposites on a glassy carbon electrode. The sensor exhibited excellent electrochemical response to BPA in 0.2 M PBS (pH 7.0) under optimal selection conditions. The linear range of the sensor was 0.01–43 μM, and the detection limit (S/N = 3) was 0.0017 μM. In addition, the sensor exhibited good immunity, stability and reproducibility. And it was applied to the detection of real samples.
An Adolescent With a Giant Ovarian Cyst and Hyperandrogenism: Case Report
Authors: Moreno-Alfonso Julio César , Hernández Martín Sara , Ayuso González Lidia , Pérez Martínez Alberto 
Published: January 2025

Objective: To present a rare diagnosis of polycystic ovary syndrome (PCOS) after initial suspicion of malignancy. PCOS is a common endocrine disorder in adolescence characterized by hyperandrogenism and polycystic ovaries.Case Presentation: A 13‐year‐old female patient was referred for a giant mass noted on examination for metrorrhagia. She had previously presented for hirsutism and acne, treated independently. A multicystic abdominal tumor measuring 21 × 17 × 9 cm was identified, with a nodular image and negative tumor markers, but elevated testosterone and LH/FSH ratio. Therefore, video‐assisted ovarian cystectomy was performed. Finally, the patient was diagnosed with PCOS and began hormonal therapy, with improvement of hyperandrogenism.Conclusion: In adolescents with large ovarian cysts, in addition to ruling out malignant neoplasms, PCOS should be considered as these may have similar clinical and radiological presentations.
A Temporal Analysis of Cash Waqf Formation and Capital in the Ottoman Balkans, 1500–1921: Founders’ Titles and Social Status
Authors: Altay Bora , Bulut Mehmet 
Published: January 2025

Abstract
This study investigates the long-term dynamics of cash waqf formation and capital in the Ottoman context with a focus on temporal variations. This examination, based on cash waqf deeds in the Balkan provinces, reveals that the real average capital levels generally declined from the mid-sixteenth to the early twentieth century. Furthermore, the findings indicate that the cash waqfs of titled individuals possessed higher capital than those of untitled individuals, but this trend shifted in favor of the latter from the second half of the nineteenth century onward. Additionally, the novel dataset used in this study allows us to explore the main trends in services funded by cash waqfs regarding founders’ social status. This study provides an overview of cash waqf formation in the Ottoman Balkans and sheds light on the relative positions of the titled groups in this process.
Improved Visualization of Oropharyngeal Tumors Using Simple Maneuvers During Flexible Endoscopy
Authors: Rahman Arifeen S. , Wang Vickie J. , Paderno Alberto , Bedi Nikita , Montalbaron Michael , Damrose Edward , Chen Michelle M. , Finegersh Andrey , Lee Jake J. , Holsinger F. Christopher 
Published: January 2025

Objectives: To describe patient positioning maneuvers that optimize visualization of the oropharynx during flexible endoscopy Methods: An institutional database of videos obtained from 2021 to 2023 during flexible endoscopy of patients with oropharyngeal carcinoma (OPC) was reviewed. Patients seen outside the specialty head and neck clinic, those with tonsillar primary tumors, and those only with videos of fiberoptic swallowing evaluations were excluded. A total of 10 videos were then independently analyzed by 2 reviewers to assess the effects of 4 maneuvers on oropharyngeal tumor visualization: chin elevation, phonation, tongue protrusion, and contralateral head turn. After segmentation analysis in Label Studio, total surface area (SA) of visualized tumor in pixels was calculated in Python and compared against the maximum width of the epiglottis to calculate relative SA. Results: Four different maneuvers were evaluated in this study: (1) chin elevation [n = 4]; (2) phonation [n = 9]; (3) tongue protrusion [n = 4]; and (4) contralateral head turn [n = 9]. The maneuvers on average increased the visualization of tumor surface area(SA) compared to baseline view: contralateral turn increased SA by 1.7 fold (95% CI = 1.11-2.34), phonation increased SA by 1.7 fold (95% CI = 1.11-2.37), tongue protrusion increased SA by 1.5 fold (95% CI = 1.16-1.80), and chin elevation increased SA by an average of 2.7 fold (95% CI = 0.74-4.72). Conclusion: Instituting simple additional positioning techniques during flexible endoscopy for patients with oropharyngeal tumors can improve visualization and staging for baseline assessment and staging.