bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidromic snare technique for re-implantation of a coronary sinus lead into the same cardiac vein after transvenous lead extraction: a case report
Authors: Kim Juwon , Chung Tae-Wan , Park Seung-Jung 
Published: December 2023

Abstract

Background
After coronary sinus (CS) lead extraction in patients with cardiac resynchronization therapy (CRT), occlusion of the branch vessel from which CS lead was extracted is a major obstacle to re-implantation, particularly if that vessel is the only optimal vessel for resynchronization.

Case summary
A 75-year-old female who underwent CRT implantation 11 years prior presented with worsening dyspnoea, right ventricle-only pacing rhythm, and increased CS lead pacing threshold. Because she was a CRT responder, we decided to replace the malfunctioning CS lead. After successful extraction, the vessel from which CS lead was extracted was not visualized, and guidewire re-insertion attempts failed. No other branch vessels suitable for re-implantation were observed. Fortunately, distal portion of the target vessel was viewed by a retrograde flow of contrast. A guidewire was advanced retrograde into the target vein via a connecting vessel, and the distal end of the guidewire was snared around CS ostium and then pulled out of the sheath. A new CS lead was inserted through the distal end of the guidewire and successfully implanted antegrade into the same target vein using a veno-venous loop of the guidewire (‘anti-dromic snare technique’). The patient was discharged 2 days after the procedure without complications.

Discussion
Antegrade re-implantation of CS lead may not be possible after extracting CS leads with long dwell times, possibly due to extraction-induced vessel occlusion. If the occluded vessel is the only proper vessel for CS lead re-implantation, the anti-dromic snare technique could be a safe and effective bail-out strategy.
The potential benefit of statin prescription based on prediction of treatment responsiveness in older individuals: an application to the PROSPER randomized controlled trial
Authors: Nguyen Tri-Long , Trompet Stella , Brodersen John B , Hoogland Jeroen , Debray Thomas P A , Sattar Naveed , Jukema J Wouter , Westendorp Rudi G J 
Published: December 2023

Abstract

Aims
Clinical guidelines often recommend treating individuals based on their cardiovascular risk. We revisit this paradigm and quantify the efficacy of three treatment strategies: (i) overall prescription, i.e. treatment to all individuals sharing the eligibility criteria of a trial; (ii) risk-stratified prescription, i.e. treatment only to those at an elevated outcome risk; and (iii) prescription based on predicted treatment responsiveness.

Methods and results
We reanalysed the PROSPER randomized controlled trial, which included individuals aged 70–82 years with a history of, or risk factors for, vascular diseases. We conducted the derivation and internal–external validation of a model predicting treatment responsiveness. We compared with placebo (n = 2913): (i) pravastatin (n = 2891); (ii) pravastatin in the presence of previous vascular diseases and placebo in the absence thereof (n = 2925); and (iii) pravastatin in the presence of a favourable prediction of treatment response and placebo in the absence thereof (n = 2890). We found an absolute difference in primary outcome events composed of coronary death, non-fatal myocardial infarction, and fatal or non-fatal stroke, per 10 000 person-years equal to: −78 events (95% CI, −144 to −12) when prescribing pravastatin to all participants; −66 events (95% CI, −114 to −18) when treating only individuals with an elevated vascular risk; and −103 events (95% CI, −162 to −44) when restricting pravastatin to individuals with a favourable prediction of treatment response.

Conclusion
Pravastatin prescription based on predicted responsiveness may have an encouraging potential for cardiovascular prevention. Further external validation of our results and clinical experiments are needed.

Trial registration
ISRCTN40976937.
An analysis of COVID-19 vaccination campaign in Ukraine
Authors: Mamontova Tetiana Vasylivna 
Published: December 2023

Abstract

Background
The Coronavirus disease (COVID-19) pandemic is still an important problem of concern in Ukraine. The rapid deployment of the vaccination program is a key event for the formation of herd immunity and helps to prevent negative outcomes, overloading the public health system.

Methods
The object of the retrospective-archival study was a depersonalized database of open panels on the management of the COVID-19 situation from the Ministry of Health of Ukraine.

Results
The total number of COVID-19 cases in Ukraine as of 25 December 2022 amounted to 5 314 388 individuals (12.83% of the population), and COVID-19-related deaths reached 110 029 individuals (0.26% of the population). The overall number of COVID-19 vaccinated persons in Ukraine as of 16 January 2022, with one dose was 36 198 per 100 000 persons (36% of the population), and with two doses, it was 34 703 per 100 000 persons (35% of the population). It was shown a decrease in the number of COVID-19 vaccinated persons among men and persons over the age of 70. In the dynamics of COVID-19 vaccination with one and two doses, an increase in the number of persons vaccinated with Pfizer/BioNTech and CoronaVac was noted.

Conclusions
Despite the significant increase in the morbidity and mortality rates of COVID-19, the coverage of vaccination among the population remained insufficient in Ukraine. The effective COVID-19 vaccination strategy should include appropriate management and ensuring the public health system capacity, implementation of information technologies to address logistics issues, and clear communication strategies to maintain public trust.
Associations between neighbourhood characteristics, physical activity and depressive symptoms: the Northern Finland Birth Cohort 1966 Study
Authors: Rautio Nina , Seppänen Marjo , Timonen Markku , Puhakka Soile , Kärmeniemi Mikko , Miettunen Jouko , Lankila Tiina , Farrahi Vahid , Niemelä Maisa , Korpelainen Raija 
Published: December 2023

Abstract

Background
Due to rapid urbanization, there is a need to better understand the relative roles of residential environment and physical activity in depression. We aimed to investigate whether neighbourhood characteristics are related to the presence of depressive symptoms and whether the association is modified by physical activity.

Methods
This cross-sectional study used the 46-year-old follow-up data (n = 5489) from the Northern Finland Birth Cohort 1966. Data on depressive symptoms, measured by Beck Depression Inventory-II, and self-reported and accelerometer-measured physical activity were included. Neighbourhood characteristics, population density, distance to the closest grocery store, bus stops and cycle/pedestrian paths, distance to the nearest parks and forests, residential greenness and level of urbanicity were calculated using Geographic Information System methods based on participants’ home coordinates.

Results
According to ordinal logistic regression analyses adjusted for physical activity at different intensities and individual covariates, living in a neighbourhood with higher population density and urbanicity level were associated with a higher risk of experiencing more severe depressive symptoms. Higher residential greenness was associated with a lower risk of experiencing more severe depressive symptoms after adjustment for self-reported light and moderate-to-vigorous physical activity, accelerometer-measured moderate-to-vigorous physical activity and individual covariates. Both higher self-reported and accelerometer-measured physical activity were independently associated with a lower risk of more severe depressive symptoms.

Conclusions
Both residential environment and physical activity behaviour play an important role in depressive symptoms; however, further research among populations of different ages is required. Our findings can be utilized when designing interventions for the prevention of depression.
A marker weighting approach for enhancing within-family accuracy in genomic prediction
Authors: Montesinos-López Osval A , Crespo-Herrera Leonardo , Xavier Alencar , Godwa Manje , Beyene Yoseph , Pierre Carolina Saint , de la Rosa-Santamaria Roberto , Salinas-Ruiz Josafhat , Gerard Guillermo , Vitale Paolo , Dreisigacker Susanne , Lillemo Morten , Grignola Fernando , Sarinelli Martin , Pozzo Ezequiel , Quiroga Marco , Montesinos-López Abelardo , Crossa José 
Published: December 2023

Abstract
Genomic selection is revolutionizing plant breeding. However, its practical implementation is still very challenging, since predicted values do not necessarily have high correspondence to the observed phenotypic values. When the goal is to predict within-family, it is not always possible to obtain reasonable accuracies, which is of paramount importance to improve the selection process. For this reason, in this research, we propose the Adversaria-Boruta (AB) method, which combines the virtues of the adversarial validation (AV) method and the Boruta feature selection method. The AB method operates primarily by minimizing the disparity between training and testing distributions. This is accomplished by reducing the weight assigned to markers that display the most significant differences between the training and testing sets. Therefore, the AB method built a weighted genomic relationship matrix that is implemented with the genomic best linear unbiased predictor (GBLUP) model. The proposed AB method is compared using 12 real data sets with the GBLUP model that uses a nonweighted genomic relationship matrix. Our results show that the proposed AB method outperforms the GBLUP by 8.6, 19.7, and 9.8% in terms of Pearson’s correlation, mean square error, and normalized root mean square error, respectively. Our results support that the proposed AB method is a useful tool to improve the prediction accuracy of a complete family, however, we encourage other investigators to evaluate the AB method to increase the empirical evidence of its potential.
Genome assemblies of two species of porcelain crab, Petrolisthes cinctipes and Petrolisthes manimaculis (Anomura: Porcellanidae)
Authors: Angst Pascal , Dexter Eric , Stillman Jonathon H 
Published: December 2023

Abstract
Crabs are a large subtaxon of the Arthropoda, the most diverse and species-rich metazoan group. Several outstanding questions remain regarding crab diversification, including about the genomic capacitors of physiological and morphological adaptation, that cannot be answered with available genomic resources. Physiologically and ecologically diverse Anomuran porcelain crabs offer a valuable model for investigating these questions and hence genomic resources of these crabs would be particularly useful. Here, we present the first two genome assemblies of congeneric and sympatric Anomuran porcelain crabs, Petrolisthes cinctipes and Petrolisthes manimaculis from different microhabitats. Pacific Biosciences high-fidelity sequencing led to genome assemblies of 1.5 and 0.9 Gb, with N50s of 706.7 and 218.9 Kb, respectively. Their assembly length difference can largely be attributed to the different levels of interspersed repeats in their assemblies: The larger genome of P. cinctipes has more repeats (1.12 Gb) than the smaller genome of P. manimaculis (0.54 Gb). For obtaining high-quality annotations of 44,543 and 40,315 protein-coding genes in P. cinctipes and P. manimaculis, respectively, we used RNA-seq as part of a larger annotation pipeline. Contrarily to the large-scale differences in repeat content, divergence levels between the two species as estimated from orthologous protein-coding genes are moderate. These two high-quality genome assemblies allow future studies to examine the role of environmental regulation of gene expression in the two focal species to better understand physiological response to climate change, and provide the foundation for studies in fine-scale genome evolution and diversification of crabs.
Genetic Affinities and Adaptation of the South-West Coast Populations of India
Authors: Kumar Lomous , Chowdhari Anuhya , Sequeira Jaison J , Mustak Mohammed S , Banerjee Moinak , Thangaraj Kumarasamy 
Published: December 2023

Abstract
Evolutionary event has not only altered the genetic structure of human populations but also associated with social and cultural transformation. South Asian populations were the result of migration and admixture of genetically and culturally diverse groups. Most of the genetic studies pointed to large-scale admixture events between Ancestral North Indian (ANI) and Ancestral South Indian (ASI) groups, also additional layers of recent admixture. In the present study, we have analyzed 213 individuals inhabited in South-west coast India with traditional warriors and feudal lord status and historically associated with migratory events from North/North West India and possible admixture with West Eurasian populations, whose genetic links are still missing. Analysis of autosomal Single Nucleotide Polymorphism (SNP) markers suggests that these groups possibly derived their ancestry from some groups of North West India having additional Middle Eastern genetic components. Higher distribution of West Eurasian mitochondrial haplogroups also points to female-mediated admixture. Estimation of Effective Migration Surface (EEMS) analysis indicates Central India and Godavari basin as a crucial transition zone for population migration from North and North West India to South-west coastal India. Selection screen using 3 distinct outlier-based approaches revealed genetic signatures related to Immunity and protection from Viral infections. Thus, our study suggests that the South-west coastal groups with traditional warriors and feudal lords’ status are of a distinct lineage compared to Dravidian and Gangetic plain Indo-Europeans and are remnants of very early migrations from North West India following the Godavari basin to Karnataka and Kerala.
Leukocyte Telomere Length and the Risk of Prostate Cancer and Benign Prostatic Hyperplasia: Insights From UK Biobank and Mendelian Randomization Study
Authors: Lv Kaikai , Wu Yangyang , Yang Guorong , Hao Xiaowei , Huang Shuai , Song Tao , Yuan Qing 
Published: December 2023

Abstract

Background
Previous observational studies have been controversial regarding the association of leukocyte telomere length (LTL) with prostate cancer (PCa) and benign prostatic hyperplasia (BPH).

Methods
First, we conducted an observational study utilizing UK Biobank data. The correlation between LTL and the risk of PCa and BPH was evaluated via multivariate-adjusted logistic regression. Then, we conducted a 2-sample Mendelian randomization to examine causal links between LTL (472 174 individuals) and PCa as well as BPH. To verify the reliability of the primary analysis, we conducted a second analysis and sensitivity analyses.

Results
In the UK Biobank study, individuals in the longer quartiles of LTL were observed to have a higher risk of PCa (1.155-fold to 1.349-fold, all p &lt; .001) and BPH (1.119-fold to 1.212-fold, all p &lt; .001) compared to those in the lowest quartile in multivariate-adjusted logistic regression. We observed that genetically predicted longer LTL resulted in a 1.427-fold risk of PCa (odds ratio [OR] = 1.427, 95% confidence interval [CI] = 1.197–1.702, p &lt; .001) and 1.539-fold risk of BPH (OR = 1.539, 95% CI = 1.387–1.707, p &lt; .001) in the primary analysis. In the second analysis, the results also indicated that longer LTL increased the genetic liability to both PCa (OR = 1.338, 95% CI = 1.189–1.507, p &lt; .001) and BPH (OR = 1.006, 95% CI = 1.003–1.008, p &lt; .001). Sensitivity analyses also supported the reliability of the results.

Conclusions
Our study provides convincing evidence supporting that longer LTL increases the risk of PCa and BPH in European individuals. Large-scale studies are needed to elucidate the potential mechanisms of LTL in PCa and BPH occurrence.
The Botrytis cinerea effector BcXYG1 suppresses immunity in Fragaria vesca by targeting FvBPL4 and FvACD11
Authors: Su Liyao , Zhang Tian , Yang Bin , Bai Yibo , Fang Wanping , Xiong Jingsong , Cheng Zong-Ming (Max) 
Published: December 2023

Abstract
Botrytis cinerea is one of the most destructive pathogens in strawberry cultivation. Successful infection by B. cinerea requires releasing a large number of effectors that interfere with the plant’s immune system. One of the effectors required by B. cinerea for optimal virulence is the secreted protein BcXYG1, which is thought to associate with proteins near the plasma membrane of the host plant to induce necrosis. However, the host proteins that associate with BcXYG1 at the plasma membrane are currently unknown. We found that BcXYG1 binds to FvBPL4 and FvACD11 at the plasma membrane. Both FvBPL4 and FvACD11 are negative regulators of plant immunity in strawberry. Our results demonstrate that degradation of FvBPL4 by BcXYG1 promotes disease resistance while stabilization of FvACD11 by BcXYG1 suppresses the immune response. These findings suggest that BcXYG1 suppresses plant immunity and promotes B. cinerea infection by regulating FvBPL4 and FvACD11 protein levels.
Predicting 1-year non-cancer-related adverse events after lung resection
Authors: Eguchi Takashi , Ide Shogo , Matsuoka Shunichiro , Iijima Yasuhiro , Mishima Shuji , Hara Daisuke , Kumeda Hirotaka , Miura Kentaro , Hamanaka Kazutoshi , Shimizu Kimihiro 
Published: December 2023

Abstract

OBJECTIVES
Assessing the risk for non-cancer-related outcomes following lung cancer surgery is crucial for high-risk patients. This study examined non-cancer-related adverse events within 1 year after lung resection, emphasizing the role of resected lung volume and postoperative atrial fibrillation (POAF).

METHODS
We conducted a retrospective analysis of 460 patients who underwent anatomical lung resection for malignant lung tumours. We assessed perioperative factors, such as the number of resected subsegments and POAF, as potential predictors of 1-year non-cancer-related adverse events. Additionally, we validated a previously published nomogram for predicting POAF.

RESULTS
One-year non-cancer-related adverse events occurred in 20% of patients. Multivariable analysis identified higher age, lower percentage-predicted forced expiratory volume in 1 second, greater number of resected subsegments and POAF as independent predictors of these adverse events. The incidence of POAF was 8.5%, with higher age, history of atrial fibrillation, and open thoracotomy as independent predictors. A temporal link between POAF and other severe postoperative complications was observed, as 71% of POAF cases preceded other complications. The nomogram's predicted risk for POAF was associated well with the actual incidence.

CONCLUSIONS
Resected lung volume and POAF are statistically significant factors associated with non-cancer-related outcomes after lung resection. Minimizing resected lung volume when oncologically and technically feasible, along with identifying patients at risk for POAF, may contribute to improved postoperative outcomes. Our results have implications for risk stratification and preoperative decision-making in lung cancer surgery.
Making Data Visualizations, Contesting Security: Digital Humanities Meet International Relations
Authors: Aradau Claudia , Blanke Tobias , Hussain Ibtehal 
Published: December 2023

Abstract
This article brings debates about data visualization in digital humanities in conversation with critical security studies and international relations. Building on feminist approaches in digital humanities, we explore the potential and limitations of data visualization as a critical method for research on (in)security. We unpack three aspects of making data visualizations by specifying “making” in this context as working, orienting, and critiquing. Making data visualizations as a methodological device is oriented by questions about the contestation of security and orients research by provoking new questions about practices of critique. Empirically, we situate data visualizations within British parliamentary debates about the Government Communications Headquarters (GCHQ), the UK's signals intelligence agency, which has garnered much public attention in the wake of the Snowden disclosures of transnational mass surveillance. We argue that data visualization in the parliamentary archive can destabilize dominant understandings of security, problematize narratives of security actors and oversight, and attend to the uneven presence of critique and contestation within and beyond parliamentary debates.
Antimicrobial resistance expansion in pathogens: a review of current mitigation strategies and advances towards innovative therapy
Authors: Adefisoye Martins A , Olaniran Ademola O 
Published: December 2023

AbstractThe escalating problem of antimicrobial resistance (AMR) proliferation in clinically important pathogens has become one of the biggest threats to human health and the global economy. Previous studies have estimated AMR-associated deaths and disability-adjusted life-years (DALYs) in many countries with a view to presenting a clearer picture of the global burden of AMR-related diseases. Recently, several novel strategies have been advanced to combat resistance spread. These include efflux activity inhibition, closing of mutant selection window (MSW), biofilm disruption, lytic bacteriophage particles, nanoantibiotics, engineered antimicrobial peptides, and the CRISPR-Cas9 gene-editing technique. The single or integrated deployment of these strategies has shown potentialities towards mitigating resistance and contributing to valuable therapeutic outcomes. Correspondingly, the new paradigm of personalized medicine demands innovative interventions such as improved and accurate point-of-care diagnosis and treatment to curtail AMR. The CRISPR-Cas system is a novel and highly promising nucleic acid detection and manipulating technology with the potential for application in the control of AMR. This review thus considers the specifics of some of the AMR-mitigating strategies, while noting their drawbacks, and discusses the advances in the CRISPR-based technology as an important point-of-care tool for tracking and curbing AMR in our fight against a looming ‘post-antibiotic’ era.