bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaginal leiomyoma: Advantages of clinical sonovaginography and ultrasound dynamic evaluation of uterine cervix‐related lesions
Authors: do Amaral Cristiana Coutinho , Castro Pedro Teixeira , Frota Rachel , de Freitas Lima Luiz Alberto Coutinho , Sobreira Iris , Araujo Júnior Edward , Werner Heron 
Published: October 2023

Abstract
Evaluation of vaginal leiomyoma by dynamic transvaginal ultrasound improves the diagnosis, with the impact on surgical planning, and surgical outcomes.
Sonovaginography using three‐dimensional ultrasound allows the assessment of spatial relationship between the cervix and the tumor.
Dietary salt intake and diabetes complications in patients with diabetes: An overview
Authors: Horikawa Chika , Sone Hirohito 
Published: October 2023

AbstractDietary salt restriction is an essential constituent of diabetes care in preventing or slowing the development of diabetes complications, and many diabetes management guidelines include recommendations for dietary salt intake. However, descriptions of guidelines for salt intake are sometimes confined to studies of participants without diabetes or small short‐term studies of patients with diabetes. However, in response to such situations, recent longitudinal studies of patients with diabetes have reported an association between dietary salt intake and diabetes complications. Thus, this review summarizes important points in the current situation regarding guidelines on salt intake and the latest findings and future issues on dietary salt intake for diabetes care focusing on (i) the current status and issues regarding the leading guidelines for dietary salt intake for diabetes care in various regions worldwide, and (ii) findings on salt intake from recent longitudinal studies of patients with diabetes whose dietary salt intake was restricted.
Bath‐related deaths: Preventive strategies and suggestions for general physicians
Authors: Suzuki Hideto , Hikiji Wakako , Fukunaga Tatsushige 
Published: October 2023

AbstractBath‐related deaths occur frequently in Japan, particularly in the elderly population; however, this fact is not sufficiently well known by the public. The advent of a super‐aging society will expose general physicians to more cases of fatal and nonfatal bath‐related accidents. As many of the victims have one or more lifestyle‐related diseases, general physicians will play a more important role in preventing these fatalities in the future. In addition, general physicians may have to perform postmortem examinations in these cases. This review article addresses the latest studies on bath‐related deaths from various medical departments, including forensic medicine, emergency medicine, and physiology. We also discuss preventive strategies based on the assumed mechanisms, and because Japan does not have a well‐developed system of medical examiners, we also provide suggestions for physicians who will encounter bath‐related deaths in the future.
Efficacy of local treatment for isolated liver metastasis after pancreatectomy in pancreatic ductal adenocarcinoma: A propensity score‐matched analysis
Authors: Yun Won‐Gun , Han Youngmin , Lee Mirang , Cho Young Jae , Jung Hye‐Sol , Kwon Wooil , Jang Jin‐Young 
Published: October 2023

AbstractBackgroundAlthough attempts of local treatment for isolated liver recurrence in patients with pancreatic ductal adenocarcinoma (PDAC) have increased, the efficacy remains unclear. Therefore, we aimed to evaluate the effect of local treatment for recurrent liver lesions after pancreatectomy on the survival of patients with PDAC.MethodsPatients who were diagnosed with isolated liver recurrence after pancreatectomy at a high‐volume center were included. We classified these patients based on the treatment options after recurrence and performed propensity score matching to minimize confounding.ResultsMedian with interquartile range survival after recurrence was significantly longer for patients who underwent local treatment for recurrent liver lesions plus chemotherapy (22.0 [17.0–29.0] months) than those treated with chemotherapy alone (13.0 [7.0–21.0] months, p = .027). In multivariate analysis, not only local treatment for recurrent liver lesions plus chemotherapy (hazard ratio [95% confidence interval], 0.55 [0.32–0.94]; p = .030) but also indicators for systemically controlled tumor such as late recurrence (0.57 [0.35–0.92]; p = .021), chemotherapy for ≥6 months (0.25 [0.15–0.42]; p < .001), and disease control by chemotherapy (0.36 [0.22–0.60]; p < .001) were identified as favorable prognostic factors.ConclusionsPDAC patients with stable recurrent liver lesions should be considered a candidate for local treatment.
The return of the “Mistigri” (virus adaptative gain by gene loss) through the SARS‐CoV‐2 XBB.1.5 chimera that predominated in 2023
Authors: Colson Philippe , Delerce Jérémy , Fantini Jacques , Pontarotti Pierre , La Scola Bernard , Raoult Didier 
Published: October 2023

AbstractSevere acute respiratory syndrome coronavirus 2 XBB.1.5 is the first recombinant lineage to predominate at the country and global scales. Very interestingly, like the Marseille‐4B subvariant (or B.1.160) and the pandemic variant B.1.1.7 (or Alpha) previously, it has its ORF8 gene inactivated by a stop codon. We aimed here to study the distribution of stop codons in ORF8 of XBB.1.5 and non‐XBB.1.5 genomes. We identified that a stop codon was present at 89 (74%) ORF8 codons in ≥1 of 15 222 404 genomes available in GISAID. The mean proportion of genomes with a stop codon per codon was 0.11% (range, 0%–7.8%). In addition, a stop codon was detected at 15 (12%) codons in at least 1000 genomes. These 15 codons are notably located on seven stem‐loop hairpin regions and in the signal peptide region for the case of the XBB.1.5 lineage (codon 8). Thus, it is very likely that stop codons in ORF8 gene contributed on at least three occasions and independently during the pandemic to the evolutionary success of a lineage that became transiently predominant. Such association of gene loss with evolutionary success, which suits the recently described Mistigri rule, is an important biological phenomenon very unknown in virology while largely described in cellular organisms.
Beta‐hydroxy‐β‐methyl butyrate‐supplemented diet for broiler chickens is more conducive to dietary protein reduction than a leucine‐supplemented diet until 21 days old
Authors: Kop Bozbay Canan , Yılmaz Berkan , Ocak Nuh 
Published: October 2023

AbstractBACKGROUNDDietary l‐leucine or its metabolite 𝛽‐hydroxy‐𝛽‐methylbutyrate (HMB) has a crucial role in the muscle protein metabolism of broilers during the first few‐week growing period. The present study aimed to evaluate the effects of l‐leucine (LLPD) or HMB (HLPD) supplementation in a low‐protein diet (20%, LPD) until 21 days old on performance, carcass weight, muscle yield and meat quality, as well as intestinal morphometry, in broiler chickens.RESULTSFrom days 1–42, LPD decreased body weight gain and feed intake (FI) and increased feed conversion ratio compared to a standard protein diet (22%, SPD). The LLPD and HLPD did not affect FI, but the LLPD decreased the body weight gain and increased the feed conversion ratio compared to the SPD. The LPD group had lower body and muscle weights than other groups. Compared to LPD, HLPD increased dressing percentage. The LPD decreased the serum insulin‐like growth factor‐1 content compared to the SPD and LLPD. The duodenal villus height of the LPD and LLPD broilers was smaller than those of the SPD and HLPD birds. The HLPD broilers had lower duodenal villus width than the SPD birds. The duodenal crypt depth and ileal mucosal thickness were higher in the HLPD group than in other groups. The HLPD and LLPD enhanced the ileal villus height compared to the SPD. The LLPD and HLPD treatments did not affect meat quality traits compared to the SPD treatment.CONCLUSIONDietary HMB could be a conducive approach to reducing dietary protein for broilers until 21 days old. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Growth kinetics of Lactococcus lactis and Lactobacillus casei in liquid culture medium containing as prebiotics inulin or fructose
Authors: Montes Yessenia Maribel García , Calle Edwin Rafael Vera , Terán Stalin Gustavo Santacruz , García Marlon Reinaldo Castro , Nájera Jenny Cumandá Ruales , Vera Mario René Lopez 
Published: October 2023

AbstractBACKGROUNDPredictive microbiology is a tool that allows us to evaluate the behavior of the concentration of biomass and estimated cells under extrinsic conditions, providing scientific and industrial benefits. In the present study, the growth of L. lactis and L. casei combined with inulin and fructose was modeled using the Gompertz sigmoidal growth functions and plotted using data obtained from batch culture in relation to biomass and cell concentration expressed as estimates in ln N (OD600nm and cells mL−1) as a function of time.RESULTSThe results of the kinetic modeling indicated that (T1) A1B1 = L. lactis + fructose and (T4) A2B2 = L. casei + inulin presented the best function coefficients and best fits in most cases compared to the rest. The specific growth rate of the maximum acceleration was from 0.364 to 0.473 h−1 and 0.100 to 0.129 h−1, the concentration of bacterial cells (A) was from 0.556 to 0.713 and 0.425 to 0.548 respectively and the time where (μ) occurred with a greater magnitude (L) fluctuated between 0.854 and 0.802 and when this time in (L) is very fast, it presents values of ≤0.072 to ≤0.092. Its coefficient of determination and/or multiple regression (R2) obtained in the two adjustments was 0.97.CONCLUSIONIt was possible to predict the influence of the carbon source on the behavior of maximum growth rates, higher consumption due to nutrient affinity and shorter growth time. © 2023 Society of Chemical Industry.
Combining Alginate/PVPI‐Based Film with Frequency Rhythmic Electrical Modulation System (FREMS) Technology as an Advanced Strategy for Diabetic Wounds
Authors: Contardi Marco , Summa Maria , Lenzuni Martina , Miracoli Luigi , Bertora Franco , Mendez Maurizio Diaz , Athanassiou Athanassia , Bertorelli Rosalia 
Published: October 2023

AbstractDiabetes is rising as one of the most diffused diseases of the century with the related urgent necessity to face its systemic and local effects on the patients, such as cardiovascular problems, degeneration of limbs, and dysfunction of the wound healing process. The diffusion of leg ulcers has been estimated to be 1.51 for 1000 population, and these non‐resolved wounds can produce several social, economic, and mental health issues in diabetic patients. At the same time, these people experience neuropathic pain that causes morbidity and a further decrease in their quality of life. Here, a new study is presented where asodium alginate/Polyvinylpyrrolidone‐Iodine complex (PVPI)‐based wound dressing is combined with the Frequency Rhythmic Electrical Modulation System (FREMS) technology, an established medical device for the treatment of neuropathic pain and diabetic ulcers. The produced Alginate/PVPI‐based films are characterized in terms of morphology, chemistry, wettability, bio‐/hemo‐compatibility, and clotting capacity. Next, the Alginate/PVPI‐based films are used together with FREMS technology in diabetic mice models, and synergism of their action in the wound closure rate and anti‐inflammatory properties is found. Hence, how the combination of electrical neurostimulation devices and advanced wound dressings can be a new approach to improve chronic wound treatment is demonstrated.
Erythrocytic α‐Synuclein and the Gut Microbiome: Kindling of the Gut‐Brain Axis in Parkinson's Disease
Authors: Yang Ying , Stewart Tessandra , Zhang Can , Wang Pan , Xu Zhi , Jin Jinghua , Huang Yang , Liu Zongran , Lan Guoyu , Liang Xingguang , Sheng Lifu , Shi Min , Cai Zhijian , Zhang Jing 
Published: October 2023

AbstractBackgroundProgressive spreading of α‐synuclein via gut‐brain axis has been hypothesized in the pathogenesis of Parkinson's disease (PD). However, the source of seeding‐capable α‐synuclein in the gastrointestinal tract (GIT) has not been fully investigated. Additionally, the mechanism by which the GIT microbiome contributes to PD pathogenesis remains to be characterized.ObjectivesWe aimed to investigate whether blood‐derived α‐synuclein might contribute to PD pathology via a gut‐driven pathway and involve GIT microbiota.MethodsThe GIT expression of α‐synuclein and the transmission of extracellular vesicles (EVs) derived from erythrocytes/red blood cells (RBCs), with their cargo α‐synuclein, to the GIT were explored with various methods, including radioactive labeling of RBC‐EVs and direct analysis of the transfer of α‐synuclein protein. The potential role of microbiota on the EVs transmission was further investigated by administering butyrate, the short‐chain fatty acids produced by gut microbiota and studying mice with different α‐synuclein genotypes.ResultsThis study demonstrated that RBC‐EVs can effectively transport α‐synuclein to the GIT in a region‐dependent manner, along with variations closely associated with regional differences in the expression of gut‐vascular barrier markers. The investigation further revealed that the infiltration of α‐synuclein into the GIT was influenced significantly by butyrate and α‐synuclein genotypes, which may also affect the GIT microbiome directly.ConclusionBy demonstrating the transportation of α‐synuclein through RBC‐EVs to the GIT, and its potential association with gut‐vascular barrier markers and gut microbiome, this work highlights a potential mechanism by which RBC α‐synuclein may impact PD initiation and/or progression. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Dimensions of Large‐Sized Network Polymers Formed in Miniemulsion Polymerization
Authors: Tobita Hidetaka 
Published: October 2023

AbstractThe mean‐square radius of gyration of network polymers can be correlated with the graph diameter, and the fraction d of segments located in the diameter chain is used to investigate the dimensions of large‐sized network polymers whose cycle rank is over 103. A simplified Monte Carlo simulation model for the miniemulsion vinyl/divinyl copolymerization is used for the generation of large‐sized network polymers, assuming the classical chemical kinetics are valid. Both conventional free‐radical polymerization and living polymerization are considered, and the heterogeneity of network architecture is controlled by changing the reactivity ratio of double bond in divinyl monomer with respect to that in vinyl monomer. The network maturity index (NMI) which is the cycle rank per primary chain is used to represent the degree of development of the network architecture. As the NMI increases to be well‐developed, the calibrated d, defined by dc = d/fd where fd is a calibration constant that shows the degree of network heterogeneity, starts to follow the master curve. This characteristic behavior applies regardless of the polymerization mechanism and the heterogeneity of the formed network architecture. Detailed characteristics of the master curve and prospects for application to gel molecules are also discussed.
In vivo measurement of T1 in the vitreous humor of patients with ischemic retinal disease
Authors: Simpson Andrew R. H. , Hughes Edward H. , Mullen Lisa , Dowell Nicholas G. 
Published: October 2023

AbstractPurposeTo demonstrate MR T1 mapping in vivo as a method to non‐invasively estimate vitreous oxygen concentration in ischemic eye disease.MethodsPatients with ischemic eye disease (central retinal vein occlusion, ocular ischemic syndrome, and proliferative diabetic retinopathy) were prospectively recruited. MRI was performed on each patient before any treatment, with T1 mapping acquired using an inversion recovery TrueFISP sequence at several inversion times, from a single slice positioned through the center of both eyes in the axial oblique plane. A phantom study measuring seven different concentrations of vitronectin, a protein released in ischemic eye disease, was undertaken to determine its potential confounding effect on T1.ResultsTen participants were recruited (eight central retinal vein occlusion, one ocular ischemic syndrome, and one proliferative diabetic retinopathy). Of the eight central retinal vein occlusion cases, there was a statistically different vitreous T1 in the diseased eye compared to the healthy control eye (4.306 vs. 4.518 s, p = 0.008). T1 times did not significantly alter across the range of vitronectin concentrations.ConclusionsIschemic eye disease decreases vitreous T1, potentially implying an increase in vitreous partial pressure of oxygen (pO2) concentration given what is known from the relationship between 1/T1 and pO2. Potential theories for this unexpected result are discussed. This study provides further data on this technique, with potential clinical application in eye disease.
A rolling horizon framework for the time‐dependent multi‐visit dynamic safe street snow plowing problem
Authors: Fröhlich Georg E. A. , Gansterer Margaretha , Doerner Karl F. 
Published: October 2023

AbstractAs a major real‐world problem, snow plowing has been studied extensively. However, most studies focus on deterministic settings with little urgency yet enough time to plan. In contrast, we assume a severe snowstorm with little known data and little time to plan. We introduce a novel time‐dependent multi‐visit dynamic safe street snow plowing problem and formulate it on a rolling‐horizon‐basis. To solve this problem, we develop an adaptive large neighborhood search as the underlying method and validate its efficacy on team orienteering arc routing problem benchmark instances. We create real‐world‐based instances for the city of Vienna and examine the effect of (i) different snowstorm movements, (ii) having perfect information, and (iii) different information‐updating intervals and look‐aheads for the rolling horizon method. Our findings show that different snowstorm movements have no significant effect on the choice of rolling horizon settings. They also indicate that (i) larger updating intervals are beneficial, if prediction errors are low, and (ii) larger look‐aheads are better suited for larger updating intervals and vice versa. However, we observe that less look‐ahead is needed when prediction errors are low.
Intersectionality in nursing research: A systematic review
Authors: Siira Elin , Linden Karolina , Wallström Sara , Björkman Ida 
Published: October 2023

AbstractAimThis systematic literature review aimed to identify, appraise and synthesize available research studies that apply intersectionality in nursing research.DesignSystematic review.Data SourcesEmpirical and theoretical nursing studies published before February 2022 were identified from the PubMed and CINAHL databases. Studies were eligible for inclusion if they substantially covered the topics of intersectionality and nursing, had undergone peer‐review, and were written in English.Review MethodsThe PRISMA 2020 statement for reporting systematic reviews was used to report findings. The Joanna Briggs Institute Critical Appraisal tools were used to assess the quality of the included research studies.ResultsOut of 331 identified studies, 60 studies were substantially about nursing and intersectionality, and were included in the review. There are a myriad of ways that the concept of intersectionality has been adopted in nursing research. Furthermore, there was great heterogeneity in the definition and application of the concept of intersectionality, and only a few studies were empirical.ConclusionThere is a need for robust and clear framing of how the concept of intersectionality is defined and understood in nursing research. There is also a need for more empirical research effectively adopting the concept of intersectionality to enhance our understanding of how health inequities operate within the field of nursing.No Patient or Public ContributionNo patients, service users, caregivers or members of the public were involved in this work.
A method for cleaning of used disposable plastic parts from automated RNA extraction system
Authors: Kumar Awanish , Shamni Ofer , Peretz Ayelet , Magenheim Judith , Klochendler Agnes , Fridlich Ori , Neiman Daniel , Oiknine‐Djian Esther , Vorontsov Olesya , Sido Tal , Wolf Dana G. , Dor Yuval , Domb Abraham J. 
Published: October 2023

AbstractDuring the first wave of COVID‐19 worldwide pandemic, the number of testing in Israel was severely affected by the shortage of reagents and consumables required to operate the instrument performing the sample extraction before the reverse transcription‐polymerase chain reaction (RT‐PCR), namely QIAsymphony instrument (Qiagen, Hilden, Germany). We aimed to develop an assay to clean used plastic ware parts while maintaining the reliability and reproducibility of the RT‐PCR testing. Wells, rods cover, and tips used by the QIAsymphony instrument were washed using distilled water, 3% sodium hypochlorite or sodium hydroxide 0.01 M solutions, followed by an additional wash using distilled water and eventually using 3% hydrogen peroxide or ethanol solution. Following overnight drying, the cleaned parts were installed in the QIAsymphony instrument, and the reliability of the results was compared to the set of samples that were analyzed using a new plastic ware. The results of reusing the cleaned sets of consumables were comparable to those of the new sets.
Successful use of extracorporeal membrane oxygenation for life‐threatening macrophage activation syndrome after treatment with tocilizumab in an systemic juvenile idiopathic arthritis patient
Authors: Yang Xi , Chen Yingfu , Dai Rongxin , An Yunfei , Yan Xin , Zhao Xiaodong , Tang Xuemei 
Published: October 2023

AbstractMacrophage activation syndrome (MAS) is a rare, potentially life‐threatening condition in rheumatic diseases. The primary treatments consist of high‐dose corticosteroids and immunosuppressive drugs, although more recently, cytokine inhibitors like anakinra or tocilizumab (TCZ) have been reported. We present a case of a child with systemic juvenile idiopathic arthritis (sJIA). After receiving a single infusion of TCZ, the child developed progressive hypoxia and was subsequently transferred to the pediatric intensive care unit (PICU) after 4 days. An immediate postintubation chest X‐ray revealed a diffuse exudative lesion. Despite continuous efforts to provide mechanical ventilation and respiratory support, the patient's oxygen saturation continued to decline. Moreover, the patient developed hemodynamic compromise, necessitating the administration of norepinephrine. Eventually, vasopressin and dopamine were added to maintain stable hemodynamics. After an intensive but ineffective treatment, extracorporeal membrane oxygenation (ECMO) was initiated in the PICU after 16 h. The patient successfully recovered and was weaned off ECMO support after 60 h. Following discharge from the PICU, given the severe refractory clinical features, we made an attempt to readminister TCZ treatment. However, within half an hour of TCZ infusion, the patient experienced anaphylaxis characterized by palpitations and chest tightness, leading to the discontinuation of TCZ. TCZ, as a biological agent, is commonly used in the treatment of sJIA. Nonetheless, the occurrence of MAS and anaphylaxis following TCZ administration for sJIA may be more prevalent than previously recognized. Pediatric rheumatologists should exercise caution when initiating TCZ for active sJIA. Furthermore, we want to underscore the importance of life‐saving techniques such as ECMO for sJIA patients in emergency situations.