bluuebunny/crossref_metadata_2025_split huggingface dataset:
The elimination of hepatitis D as a public health problem: Needs and challenges
Authors: Vanwolleghem Thomas , Armstrong Paige A. , Buti Maria , FitzSimons David , Valckx Sara , Hendrickx Greet , Van Damme Pierre 
Published: October 2023

AbstractInfection with hepatitis D virus leads to liver disease and cancer most rapidly of all hepatitis viruses. However, knowledge about hepatitis D remains poor and the burden and impact are underestimated, even though some 12–15 million people mainly in low‐ and middle‐income countries may be affected. Its epidemiology is changing, with increasing migration leading to increased risks of infection and disease. A recent Viral Hepatitis Prevention Board meeting reviewed the current epidemiological status, improvements in diagnostic testing, advances in the development of novel antiviral agents in phase III trials and the need for a greater public health response, such as new guidelines and recommended testing of all people newly identified as infected with hepatitis B virus for hepatitis D virus infection. It identified issues and needs for attention with regard to prevention, diagnosis and treatment.
Evidence‐based complementary feeding recipe book for Kenyan caregivers: A novel approach
Authors: Lowe Alyssa , Callis Amy , DiGirolamo Ann , Girard Amy W. , Boakye Amma , Ogutu Emily , Omosa Esther , Okeyo Frida , Odollo Lawrence , Samburu Betty , Arimi Caroline , Kamudoni Penjani , Gonzalez Wendy , Codjia Patrick , Kiige Laura 
Published: October 2023

AbstractThe Kenyan Ministry of Health (MOH) and a consortium of nutritionists, researchers and communication, and design specialists developed a novel approach to create an evidence‐based recipe book promoting complementary feeding (CF) in Kenya. The ADAPT approach includes five steps: applied research (A), dialogue with stakeholders (D), adapted behaviour change communication (BCC) theories (A), purpose‐driven visual communication (P), and tailoring to priority audiences (T). Through this approach, the recipe book addresses key knowledge gaps using behaviour change theories and visual communication best practice to increase accessibility, acceptability, retention and motivation for behaviour change. The book addresses barriers to CF identified through formative applied research. Dialogue with stakeholders helped ensure cultural appropriateness and the book's alignment with MOH recommendations and key messages. The book uses behaviour change theories to approach the reader in a respectful way that motivates behaviour change. The use of consistent, purpose‐driven visuals helps ensure key messages are easily understood and accessible to all caregivers regardless of literacy level. The book's tone and content are tailored to its audiences’ attributes, needs and preferences. This five‐step process inspired the development of ADAPT, a novel approach that integrates behaviour change and visual communication for greater impact. This paper outlines how the consortium used the ADAPT approach to develop an evidence‐based book that thoughtfully and holistically addresses a wide range of barriers, provides practical solutions and increases self‐efficacy around CF. It offers a blueprint for public health practitioners from any field who are interested in using visual behaviour change communication to promote healthy behaviour.
The safety of at home powdered infant formula preparation: A community science project
Authors: Grant Aimee , Jones Sara , Sibson Vicky , Ellis Rebecca , Dolling Abbie , McNamara Tara , Cooper Jonie , Dvorak Susan , Breward Sharon , Buchanan Phyll , Yhnell Emma , Brown Amy 
Published: October 2023

AbstractFormula fed infants experience gastrointestinal infections at higher rates than breastfed infants, due in part to bacteria in powdered infant formula (PIF) and bacterial contamination of infant feeding equipment. The United Kingdom National Health Service (UK NHS) has adopted the World Health Organization recommendation that water used to reconstitute PIF is ≥70°C to eliminate bacteria. We used community science methods to co‐design an at home experiment and online questionnaire (‘research diary’) to explore the safety of PIF preparation compared to UK NHS guidelines. 200 UK‐based parents of infants aged ≤12 months were recruited; 151 provided data on PIF preparation, and 143 were included in the analysis of water temperatures used to reconstitute PIF. Only 14.9% (n = 11) of 74 PIF preparation machines produced a water temperature of ≥70°C compared with 78.3% (n = 54) of 69 kettle users (p < 0.001). The mean temperature of water dispensed by PIF preparation machines was 9°C lower than kettles (Machine M = 65.78°C, Kettle M = 75.29°C). Many parents did not always fully follow NHS safer PIF preparation guidance, and parents did not appear to understand the potential risks of PIF bacterial contamination. Parents should be advised that the water dispensed by PIF preparation machines may be below 70°C, and could result in bacteria remaining in infant formula, potentially leading to gastrointestinal infections. PIF labelling should advise that water used to prepare PIF should be ≥70°C and highight the risks of not using sufficiently hot water, per WHO Europe advice. There is an urgent need for stronger consumer protections regarding PIF preparation devices.
Exploring chromosome evolution in 250 million year old groups of dragonflies and damselflies (Insecta:Odonata)
Authors: Tolman Ethan R. , Beatty Christopher D. , Bush Jonas , Kohli Manpreet K. , Frandsen Paul B. , Gosnell J. Stephen , Ware Jessica L. 
Published: October 2023

AbstractUsing recently published chromosome‐length genome assemblies of two damselfly species, Ischnura elegans and Platycnemis pennipes, and two dragonfly species, Pantala flavescens and Tanypteryx hageni, we demonstrate that the autosomes of Odonata have undergone few fission, fusion, or inversion events, despite 250 million years of separation. In the four genomes discussed here, our results show that all autosomes have a clear ortholog in the ancestral karyotype. Despite this clear chromosomal orthology, we demonstrate that different factors, including concentration of repeat dynamics, GC content, relative position on the chromosome, and the relative proportion of coding sequence all influence the density of syntenic blocks across chromosomes. However, these factors do not interact to influence synteny the same way in any two pairs of species, nor is any one factor retained in all four species. Furthermore, it was previously unknown whether the micro‐chromosomes in Odonata are descended from one ancestral chromosome. Despite structural rearrangements, our evidence suggests that the micro‐chromosomes in the sampled Odonata do indeed descend from an ancestral chromosome, and that the micro‐chromosome in P. flavescens was lost through fusion with autosomes.
Avowal under oppression
Authors: Maxwell Sydney 
Published: October 2023

AbstractLeading expressivist proposals characterize the mental state expressed in the making of a normative judgment solely in terms of intrinsic, psychological dispositions. As a result, they fail to capture a subset of the normative judgments that agents can and do make; they miss the way that external factors can influence what the making of a normative judgment looks like. This problem can be seen most plainly in the context of systemic oppression. Intuitively, one can make a normative judgment that conflicts with the oppressive ideas one has previously been conditioned to endorse, but expressivism seems to deny that this is possible. The expressivist's inability to count these avowals made under oppression as genuine normative judgments makes expressivism deficient as a metaethical theory.
New and emerging options for management of invasive fungal diseases in paediatric patients
Authors: Groll Andreas H. , Körholz Katharina , Holterhus Malcolm , Lehrnbecher Thomas 
Published: October 2023

AbstractInvasive fungal diseases (IFDs) play an important role in the supportive care of paediatric patients with acute leukaemia and those undergoing allogeneic haematopoietic cell transplantation, and they are associated with significantly decreased overall survival rates in affected individuals. Relative to adults, children and adolescents are distinct in terms of host biology, predisposing conditions, presentation and epidemiology of fungal diseases, and in the pharmacology of antifungal agents. The paediatric development of antifungal agents has moved forward in a coordinated manner, and major advances have been made regarding concepts and recommendations for the prevention and treatment of IFDs. However, antifungal therapy is increasingly complex, and a solid knowledge of the available options is needed more than ever for successful management. This narrative review provides a summary of the paediatric development of agents that have been recently approved (anidulafungin, posaconazole) or are in advanced stages of development (isavuconazole). It also reviews the emerging evidence for the efficacy of echinocandins for prophylaxis of invasive aspergillosis, presents new data on alternative dosing regimens of echinocandins and voriconazole, and provides a brief overview of new antifungal agents in clinical development that are expected to be developed for paediatric patients.
Salivary opiorphin levels in denture‐related traumatic ulcers
Authors: Ozdogan Mahmut Sertac , Gungormus Mustafa 
Published: October 2023

AbstractObjectiveOpiorphin is a pentapeptide secreted in saliva and has a strong analgesic effect. Salivary opiorphin has been shown to increase in orofacial pain and may act as a pain reliever in pain caused by denture‐related ulcers. The current study aimed to evaluate the salivary opiorphin levels in traumatic ulcers caused by ill‐fitting dentures and demonstrate whether there is any correlation between trauma‐related pain levels and salivary opiorphin levels.Materials and MethodsTwenty‐two individuals with new full dentures and a complaint of pain due to ill‐fitting were included in this study. Patients were asked to rate their level of pain on a visual analog scale (VAS). Then, saliva specimens were collected at the first visit with the complaint of pain and 7 days following the denture adjustment.ResultsThe average saliva opiorphin level before and after denture adjustment were 19.29 ± 5.44 and 15.78 ± 3.95 ng/mL, respectively. A dependent (paired) t‐test determined that the mean salivary opiorphin level differed statistically significantly before and after the adjustment of the dentures.ConclusionsThe findings show that salivary opiorphin levels increase in pain associated with denture‐related traumatic ulcers. Adjusting the dentures resulted in pain relief and a statistically significant reduction in opiorphin levels.
When do bureaucrats respond to external demands? A theoretical framework and empirical test of bureaucratic responsiveness
Authors: Rimkutė Dovilė , van der Voet Joris 
Published: October 2023

AbstractBureaucrats must balance neutral competence with responsiveness to external demands. As external demands are simultaneous and multidimensional, this study analyzes bureaucratic responsiveness according to bureaucratic actors' prioritization decisions. Using a discrete choice experiment followed by qualitative interviews in the context of EU agencies, we investigate to what extent bureaucratic responsiveness depends upon the stakeholder that expresses an external demand (source), the aspect of bureaucratic conduct that is addressed (content), and the presence of adverse media attention (salience). In addition to corroborating prior empirical findings, we provide a novel understanding of bureaucratic responsiveness by showing the way demands' source and content affect responsiveness jointly. Across the range of technical, performative, legal‐procedural, and moral demands, we identify which stakeholders can impose demands most authoritatively. We also extend previous research by demonstrating that adverse media attention strengthens responsiveness to technical and moral demands, but not to performative and legal‐procedural demands.
Effect of antifibrotic agents on postoperative complications after lung transplantation for idiopathic pulmonary fibrosis
Authors: Moncomble Elsa , Weisenburger Gaelle , Picard Clément , Dégot Tristan , Reynaud‐Gaubert Martine , Nieves Ana , Mornex Jean François , Dauriat Gaelle , Messika Jonathan , Godet Cendrine , Hirschi Sandrine , Le Pavec Jérôme , Borie Raphael , Mordant Pierre , Lortat‐Jacob Brice , Mal Hervé , Bunel Vincent 
Published: October 2023

AbstractBackgroundAntifibrotic agents (AFAs) are now standard‐of‐care for idiopathic pulmonary fibrosis (IPF). Concerns have arisen about the safety of these drugs in patients undergoing lung transplantation (LTx).MethodsWe performed a multi‐centre, nationwide, retrospective, observational study of French IPF patients undergoing LTx between 2011 and 2018 to determine whether maintaining AFAs in the peri‐operative period leads to increased bronchial anastomoses issues, delay in skin healing and haemorrhagic complications. We compared the incidence of post‐operative complications and the survival of patients according to AFA exposure.ResultsAmong 205 patients who underwent LTx for IPF during the study period, 58 (28%) had received AFAs within 4 weeks before LTx (AFA group): pirfenidone in 37 (18.0%) and nintedanib in 21 (10.2%). The median duration of AFA treatment before LTx was 13.8 (5.6–24) months. The AFA and control groups did not significantly differ in airway, bleeding or skin healing complications (p = 0.91, p = 0.12 and p = 0.70, respectively). Primary graft dysfunction was less frequent in the AFA than control group (26% vs. 43%, p = 0.02), and the 90‐day mortality was lower (7% vs. 18%, p = 0.046).ConclusionsAFA therapy did not increase airway, bleeding or wound post‐operative complications after LTx and could be associated with reduced rates of primary graft dysfunction and 90‐day mortality.
Evaluating the efficiency and safety of large‐volume leukapheresis using the Spectra Optia continuous mononuclear cell collection protocol for peripheral blood stem cell collection from healthy donors: A retrospective study
Authors: Sumii Yuichi , Fujii Keiko , Kondo Takumi , Urata Tomohiro , Kimura Maiko , Fujiwara Hideaki , Asada Noboru , Ennishi Daisuke , Nishimori Hisakazu , Matsuoka Ken‐ichi , Otsuka Fumio , Maeda Yoshinobu , Fujii Nobuharu 
Published: October 2023

AbstractBackgroundLarge‐volume leukapheresis (LVL) refers to processing of more than three volumes of blood in a single session for peripheral blood stem cell collection. Recently, continuous mononuclear cell collection (cMNC) protocol has been developed using the Spectra Optia system, which is a widely used apheresis device. LVL using the novel protocol has been investigated in patients. However, the efficiency and safety of LVL in healthy donors using this protocol has not been characterized. Therefore, this study aimed to evaluate the efficiency and tolerability of CD34+ collection of LVL with the cMNC protocol in healthy donors.Study Design and MethodsWe retrospectively collected data on LVL (>3 total blood volume) and normal‐volume leukapheresis (NVL) performed in healthy donors between October 2019 and December 2021. All procedures were performed using the cMNC protocol.ResultsAlthough pre‐apheresis CD34+ cell count was lesser in LVL (23.5 vs. 58.0/μL, p < .001), CD34+ collection efficiency was comparable between LVL and NVL (61.2% vs. 61.4%, p = .966). Platelet loss was significantly higher in LVL compared to NVL (38.0% vs. 29.4%, p < .001), with no correlation between attrition of platelet and processing blood volume. Moreover, the incidence of citrate toxicity during procedures was comparable between the two groups (31.6% vs. 21.4%, p = .322). All LVL procedures could be completed without any adverse events.ConclusionAllogeneic LVL procedure using Spectra Optia cMNC protocol was well tolerated by the donors and resulted in efficient collection of CD34+ cells, which was comparable to that of NVL.
The successful use of a subcutaneous catheter in the management of severe subcutaneous emphysema in a dog with laryngeal crush injury and tracheostomy tube placement
Authors: Poirier Maude , Walton Rebecca A. L. 
Published: October 2023

AbstractObjectiveTo describe the placement of a subcutaneous catheter in a dog for the management of severe subcutaneous emphysema secondary to severe laryngeal crushing injury and temporary tracheostomy tube placement.Case SummaryA 6‐year‐old male neutered Kelpie suffered a severe laryngeal crushing injury following a dog attack. Case management included the placement of a temporary tracheostomy tube due to severe respiratory compromise and inspiratory dyspnea associated with the crush injury. During hospitalization, the patient developed severe subcutaneous emphysema, pneumomediastinum, and a pneumothorax as a complication of the laryngeal crushing injury and temporary tracheostomy. A subcutaneous catheter was placed to manage the recurrent subcutaneous emphysema while the tracheostomy stoma healed. Five months posttrauma, the dog returned to normal with mild stridor during excitement and while panting.New or Unique Information ProvidedThis is the first report in veterinary medicine describing the use of a subcutaneous catheter for the management of subcutaneous emphysema secondary to laryngeal crush injury and temporary tracheostomy tube placement.
Meeting report: Xenotransplantation Development Conference in Neijiang, China
Authors: Huai Guoli , Schuurman Henk‐Jan , Cooper David K. C. , Bühler Léo H. , Deng Shaoping , Pan Dengke 
Published: October 2023

AbstractA conference on progress in the development of xenotransplantation in China was held in Neijiang, Sichuan, in May 2023, and was attended by approximately 100 established researchers and trainees. Progress in xenotransplantation research was reviewed by both Chinese and foreign experts. The topics discussed ranged from genetic engineering of pigs and the results of pig‐to‐nonhuman primate organ transplantation to the requirements for designated pathogen‐free (DPF) pig facilities and regulation of xenotransplantation. This conference served as an opportunity to collectively advance the development of xenotransplantation in China and pave the way for its clinical application.
Experience of having a sibling with autism spectrum disorder: a systematic review protocol
Authors: Kantor Jiří , Smrčková Alžběta , de Goumoëns Véronique , Munn Zachary , Svobodová Zuzana , Klugar Miloslav 
Published: October 2023

Objective:
This qualitative systematic review aims to understand the experiences of neurotypical siblings of a person with autism spectrum disorder (ASD).

Introduction:
ASD influences communication and social interaction with other people and has a significant impact on family relationships. The experiences of siblings range from the positive, such as development of increased empathy and ability to cope with challenges, to experiences that are more negative, such as a higher risk of bullying. In many countries, neurotypical siblings are marginalized and don’t receive adequate support to cope with the increased challenges.

Inclusion Criteria:
This review will consider qualitative studies exploring the experiences of siblings of a person with ASD. There are no limitations regarding age, gender, sex, or length of relationship with the sibling. We will consider studies from all countries and contexts.

Methods:
This study will be conducted according to JBI methodology for qualitative reviews. A 3-step search strategy will be used to find published and unpublished studies in the following sources: MEDLINE, CINAHL, APA PsycINFO, Scopus, SocINDEX, Web of Science, Embase, ERIC, ProQuest Dissertations and Theses, Open Dissertations, and Google Scholar (first 100 records). There will be no search limitations on the publication period or language, but only studies with an English-language abstract/title will be considered for inclusion. Screening, data extraction, and data synthesis will be conducted by 2 independent reviewers.
Oral hygiene care and the management of oral symptoms in patients with cancer in palliative care: a mixed methods systematic review protocol
Authors: Serra Ricardo , de Oliveira Célia Simão , Roque Sofia , Herrera Federico , Arco Helena 
Published: October 2023

Objective:
The objective of this review is to examine the effectiveness of oral hygiene care in the management of oral symptoms in patients with cancer under specialist palliative care and the patients’ experience of such symptoms and care.

Introduction:
Oral symptoms, such as xerostomia, mouth pain, or dysgeusia, are highly prevalent in patients with cancer under specialist palliative care. These symptoms have a negative effect on patients’ quality of life. Oral hygiene care can manage oral symptoms and could be improved with a more systematized approach, adequate guidelines, and training to properly integrate oral hygiene into the care provided in specialist palliative care.

Inclusion criteria:
This review will consider quantitative, qualitative, and mixed methods studies on the effectiveness and experience of oral hygiene care intended to manage oral symptoms in patients with cancer aged 18 years or older, diagnosed with any type of cancer, under specialist palliative care.

Methods:
The search will be conducted in MEDLINE (PubMed), CINAHL (EBSCOhost), Cochrane Central Register of Controlled Trials, Dentistry and Oral Sciences Source (EBSCOhost), and MedicLatina (EBSCOhost). Sources of unpublished studies and gray literature to be searched will include Networked Digital Library of Theses and Dissertations and Repositórios Científicos de Acesso Aberto de Portugal. Studies in English, Portuguese, and Spanish published from 2000 to the present will be considered. Methodological quality of included studies will be assessed and data will be extracted. Synthesis and integration will follow the JBI segregated approach for mixed methods reviews.

Review registration:
PROSPERO CRD42023400554