bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, Incidence, and Clinical Characteristics of Thyroid Eye Disease in Japan
Authors: Watanabe Natsuko , Kozaki Ai , Inoue Kosuke , Narimatsu Hiroto , Shinohara Masahiko , LoPresti Michael Goddard 
Published: November 2023

Abstract

Background
Although thyroid eye disease (TED) can impact social and psychological well-being, the epidemiological evidence of TED is lacking in Japan.

Methods
Nationwide claims databases provided by JMDC Inc. and Medical Data Vision Co., Ltd. and national population statistics are used. Three TED definitions ranging from a strict definition only including a TED diagnosis to a broad definition including a TED diagnosis and considering ocular symptoms are considered. The proportion of patients by severity and disease activity are estimated based on definitions that would allow identification of those patients within the claims data.

Results
The incidence rate per 100 000 person-years ranged from 7.3 to 11.1 for the strict and broad TED definitions, respectively. For fiscal year 2020 (April 2020 to March 2021) the prevalence rate ranged between 24.65 (strict TED) and 37.58 (broad TED) per 100 000 persons. These correspond to 25 383 and 38 697 patients for the strict and broad TED definitions, respectively. Regardless of the definition used, a predominance of female patients was observed, and the highest burden of the disease was seen in the age group of 35 to 59. Mild and inactive forms of TED were predominant (about 85% and 74%, respectively).

Conclusion
The incidence and prevalence of TED in Japan were 7.3 to 11.1 per 100 000 person-years and 24.65 to 37.58 per 100 000 persons, respectively. The robust results of this database study add valuable real-world evidence on the incidence and prevalence of TED in Japan.
Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes
Authors: Katano Wataru , Mori Shunta , Sasaki Shun , Tajika Yuki , Tomita Koichi , Takeuchi Jun K. , Koshiba-Takeuchi Kazuko 
Published: November 2023

ABSTRACT
Sall1 and Sall4 (Sall1/4), zinc-finger transcription factors, are expressed in the progenitors of the second heart field (SHF) and in cardiomyocytes during the early stages of mouse development. To understand the function of Sall1/4 in heart development, we generated heart-specific Sall1/4 functionally inhibited mice by forced expression of the truncated form of Sall4 (ΔSall4) in the heart. The ΔSall4-overexpression mice exhibited a hypoplastic right ventricle and outflow tract, both of which were derived from the SHF, and a thinner ventricular wall. We found that the numbers of proliferative SHF progenitors and cardiomyocytes were reduced in ΔSall4-overexpression mice. RNA-sequencing data showed that Sall1/4 act upstream of the cyclin-dependent kinase (CDK) and cyclin genes, and of key transcription factor genes for the development of compact cardiomyocytes, including myocardin (Myocd) and serum response factor (Srf). In addition, ChIP-sequencing and co-immunoprecipitation analyses revealed that Sall4 and Myocd form a transcriptional complex with SRF, and directly bind to the upstream regulatory regions of the CDK and cyclin genes (Cdk1 and Ccnb1). These results suggest that Sall1/4 are critical for the proliferation of cardiac cells via regulation of CDK and cyclin genes that interact with Myocd and SRF.
(No) Time for Change: When and Why Entrepreneurs Act During Underperforming Fundraising Attempts
Authors: Wilhelm Hendrik , Steigenberger Norbert , Weber Clarissa E. , Juntunen Jouni K. , Ebers Mark 
Published: November 2023

Entrepreneurs need to mobilize funds, but they do so under considerable uncertainty about resource holders’ preferences, leading often to fundraising attempts that perform below entrepreneurs’ aspirations. Past research has offered contrasting theorizing and evidence for why entrepreneurs then make changes to their product offering during such attempts as well as for why entrepreneurs refrain from taking such action. This paper develops and tests behavioral theory to reconcile this tension, explicating when and why entrepreneurs change their product offering during underperforming fundraising attempts. Specifically, we argue that entrepreneurs draw on three sources of information that are inherent to fundraising attempts and that inform the extent of their actions to change their product offering: the degree to which they perform below their own fundraising aspirations, the degree to which they fall below peer fundraising performance, and the time that remains until the deadline for the fundraising attempt. Longitudinal data on 576 fundraising campaigns (6,758 observations) published on the crowdfunding platform Kickstarter support our theory. By developing novel behavioral theory on when and why entrepreneurs take action during resource mobilization, we offer contributions to research on entrepreneurial resource mobilization, the crowdfunding literature, and the Behavioral Theory of the Firm. Funding: This work was supported by KölnAlumni. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2020.13803 .
Stimulated emission in a CuInS2/ZnS core-shell quantum-dot-doped liquid-core optical fiber
Authors: Wang Zhe , Sun Mingye , Meng Lai , Zhang Lei 
Published: November 2023

We fabricated QD liquid-core optical fibers by doping CuInS2/ZnS (CIS/ZnS) core/shell QDs with cladding times of 90 and 60 min, respectively, and compared and analyzed their emission properties with those of bare core CuInS2 QDs. For CIS/ZnS core/shell QDs (with cladding time of 90 min) doped fibers, their emission transmits the longest distance in the fiber, and the emission intensity is approximately 4.73 times that of bare-core QD-doped fibers. Additionally, the fact that the full-width at half-maximum is narrowing and the spectral intensity is rapidly increasing superlinearly with excitation power indicates that stimulated emission happens in the fiber. The optical performance was compared and showed good agreement with a theoretical two-level system model for the QDs confined in an optical waveguide.
Italian Neorealism: A Cultural History, Charles L. Leavitt IV (2020)
Authors: Garofalo Piero 
Published: November 2023

Review of: Italian Neorealism: A Cultural History, Charles L. Leavitt IV (2020)
Toronto: University of Toronto Press, xi + 313 pp.,
ISBN 978-1-48750-710-7, h/bk, $93.00
I manga: Introduzione al fumetto giapponese, Marco Pellitteri (2021)
Authors: Ghilardi Marcello 
Published: November 2023

Review of: I manga: Introduzione al fumetto giapponese, Marco Pellitteri (2021)
Roma: Carocci Editore, 167 pp.,
ISBN 978-8-82901-104-9, p/bk, €15.00
Malicious Game
Authors: Sheldon Zachary 
Published: November 2023

In the late-night cafés of Amman, Jordan, Iraqi refugees have adopted a new game, called jaakaaroo, that they say is more “malicious” than familiar favorites like dominoes or backgammon. Meanwhile, they decry the cruelty, greed, and suspicion that have eroded social bonds in their home and host countries. Borrowing concepts from Arabic philosophy, I argue that the formal routines of the game act on the same faculty of estimation (al-wahm) that migrants use to read strangers’ intentions while disguising their own. When this sense of suspicion emanates from the ingenious device of the game itself, which I theorize as a form of agent intellect (al-‘aql al-faa‘il), new and troubling feelings come to be absorbed within the broader aesthetic assemblage of teahouse sociality. In these spaces, the harshness of the present becomes enfolded within nostalgic routines—a creative act of solidarity that exceeds binary tropes of hope and uncertainty.
Pertambahan Bobot Tubuh, Panjang Tubuh dan Tinggi Tubuh Ikan Nila Merah (Oreochromis niloticus) yang Dipelihara Pada Aerasi dan Padat Tebar Berbeda
Authors: Djaelani Muhammad Anwar , Kasiyati Kasiyati , Sunarno Sunarno 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pengaruh aerasi dan padat tebar terhadap pertambahan bobot tubuh, panjang tubuh dan tinggi tubuh ikan nila merah (Oreochromis niloticus). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktorial dengan dua perlakuan, terdiri atas perlakuan kelompok dilengkapi dengan satu aerator dan perlakuan kelompok dilengkapi dengan dua aerator serta tiga tingkatan padat tebar 2,4,8 ekor ikan. Pada padat tebar normal sebanyak 2 ekor ikan nila merah dengan berat 17±1,6 g dipelihara dalam kontainer boks kapasitas 40 liter yang diisi air sebanyak 34 liter. Ikan dipelihara selama 2 bulan. Variabel yang diamati pada penelitian ini adalah pertambahan bobot tubuh, panjang tubuh dan tinggi tubuh ikan nila. Faktor lingkungan yang diamati pada penelitian ini meliputi Oksigen terlarut (DO), pH, suhu, kandungan ammonia, nitrit dan nitrat. Hasil penelitian ini menunjukkan bahwa pemeliharaan ikan nila merah dengan penambahan aerator berpengaruh nyata (P<0,05) terhadap pertambahan bobot tubuh, panjang tubuh dan tinggi tubuh ikan nila merah. This study aims to determine the effect of aeration and stocking density on body weight gain, body length and body height of red tilapia (Oreochromis niloticus). This study used a factorial completely randomized design (CRD) with two treatments, consisting of a group treatment equipped with one aerator and a group treatment equipped with two aerators and three levels of stocking density of 2,4,8 fish. At normal stocking densities, 2 red tilapia weighing 17 ± 1.6 g were reared in a 40 liter capacity box filled with 34 liters of water. Fish kept for 2 months. The variables observed in this study were the increase in body weight, body length and body height of tilapia fish. Environmental factors observed in this study include dissolved oxygen (DO), pH, temperature, ammonia, nitrite and nitrate content. The results of this study indicated that rearing red tilapia with the addition of an aerator had a significant (P<0.05) effect on body weight gain, body length and body height of red tilapia.
Understanding the impact of ChatGPT in education
Authors: Thong Chee Ling , Butson Russell , Lim WeiLee 
Published: November 2023

With the advent of Artificial Intelligence (AI) in educational settings, particularly the integration of tools like ChatGPT, research on the impact of ChatGPT in education becomes a critical and timely endeavor, especially when it includes insights from students rather than just teachers. This exploratory study aims to examine students’ attitudes, perceptions, and ethical concerns towards AI integration in learning environments by directly engaging 60 students from diverse geographical regions and educational background. The sample includes students from urban higher education and suburban high school. The study is founded on a quantitative research design and cross-sectional survey methodology. The findings reveal a clear digital divide in AI usage, with urban students demonstrating more engagement with ChatGPT for educational purposes than their suburban counterparts, thereby unveiling an underlying disparity in technological access. Ambiguity prevails among students about distinct functionalities and benefits of AI language models like ChatGPT, hinting at the need for clearer elucidation of AI’s unique capabilities. Ethical concerns also emerge, especially regarding AI accuracy and the potential for misuse leading to a decline in critical thinking skills. However, despite these challenges, students generally express optimism about the future refinement and widespread application of ChatGPT. In conclusion, this study underscores the importance of promoting digital inclusivity, establishing clear ethical guidelines, and striving for continuous improvements in AI accuracy, all while maintaining student-centric approach. Future direction suggests a focus on enhancing digital inclusivity, ethical considerations, AI accuracy and educational strategies around unique functionalities of AI tools.
Digital facelift
Authors: Britton Boyd , Vallis Carmen 
Published: November 2023

The rapid development and proliferation of synthetic media and AI-generated avatars present both challenges and opportunities for higher education. Increasingly, educational institutions must navigate complex ethical and pedagogical considerations, as well as adapt to the latest AI technologies (Siemens et al., 2022). Ethical and pedagogical principles to guide AI use are urgently needed in education (Bozkurt et al., 2021).

In this presentation, we share a practical perspective, framed by a specific case-study: the development and implementation of a large-scale, interactive business module featuring AI-generated ‘Guest Lecturers’ The AI-generated video content, along with other online activities, were designed to stimulate critical reflection and discussion about the ethical implications of AI in business. Now in its second iteration, the project represents a significant trial and evaluation of synthetic media to present educational concepts in a cohort of over 700 students.

Fundamental ethical and pedagogical questions surfaced during the development and implementation of this learning media. How transparent should educators be about the processes and tools they adopt in producing content, for example (Pataranutaporn et al., 2021)? When does human presence add value in recorded video, be it in a pedagogical or parasocial sense (Beege et al., 2019)? And what forms of learning might benefit (or not) from automating video content (Li et al., 2016)? Based on evaluation data from focus groups and video analytics, we explore these questions and the potential affordances and limitations of synthetic media. We also reflect on the tools and techniques that were used to create the project, and implications for educational institutions as they seek to build capacity for AI content creation within traditional production ecosystems.

An emergent typology for AI in educational media is explored, to help educators design for teaching and learning based on learning purposes and modes of delivery. Finally, we discuss how student feedback might inform the design, production and delivery of learning media, and future directions for student co-creation and agency.
Dismantling the education exclusion zone
Authors: Barber Ash 
Published: November 2023

Traditional textbook publishing magnifies some voices while silencing others, pushing consistently marginalised groups into an education exclusion zone. Open educational resources (OER) purportedly address this problem; however, without adequate guidance on inclusive design, OER fail to rise to the challenge. This paper undertakes an exploratory initial review of EmpoweredOER, a practical tool in first-phase iterative development, designed to unpack the complexities of inclusive OER. Emerging from a grant-funded international study tour, three best practice themes informed the design of EmpoweredOER: true accessibility, beyond technological; universal design for learning and inclusive open education nexus; and diverse perspectives and representation. Initial findings indicate EmpoweredOER meets its objective. Future research will analyse the impact and growth of EmpoweredOER as it matures.
Implications for practice:

There is appetite to dedicate further resources to developing inclusive OER tools.
Advocates can instill a sense of community in their resources for increased engagement.
Resource creators should incorporate interactivity and adaptability for greater contextualisation.
Supporting hybrid engagement through digital learning design
Authors: White Pennie , Huang Vicki , Campanale Naomi 
Published: November 2023

With the shift to post-pandemic flexible delivery there is an increased focus on the quality of online learning materials. In response to this, a project was undertaken to transform online law units sites from pdfs to interactive pages; and from 2-hour lectures to multiple short pre-recordings dedicated to a single concept. This study explored student engagement, preferences, and performance through a pragmatic and meaningful analysis of learning analytics in relation to learning design for the purpose of informing our practice. This paper draws on data involving 89 students that participated in the study from the cohort of approximately 200 students. This study confirms that the majority of students preferred the new digital learning design approach, however, the diversity of student preferences has implications for learning design that need to be taken into consideration.
Re-imagining women’s leadership in the third-space
Authors: Hinze Meredith , Rokvic Benedicte , Kelly Oriel , Whitechurch Scarlett , Bennett Miriam 
Published: November 2023

The role of the third space woman leader is a blurry one (Denney, 2021). While making a difference for students is at the heart of our work, creating and leading teams in a direction often not of our choosing and from a position that crosses many boundaries is a challenge and is often invisible or unrecognized (Tay, Huijser, Dart, & Cathcart, 2023).

No two third space women leaders arrived in this role by the same path, but all have a diverse range of skills and personal attributes to draw upon – formal qualifications, teaching experience, technical skills and experience, growth mindsets, resilience, flexibility, creativity and not afraid of change. Yet there is no model of leadership that encapsulates this eclectic range of personal expertise which enables us to work with a diverse range of people and varying digital fluencies in the tertiary teaching and learning space.

We therefore propose a new model of leadership for women working in professional staff third or liminal space roles (Loftus, 2018). A model which moves away from Servant Leadership (Smith, 2005), one of invisibility, nudging, persuading, to a more visible form of leadership - leading change from the front as well as alongside others in partnerships. A coaching and leadership style which empowers others and ourselves by flipping perceived weaknesses (no PhD, casual contracts, imposter syndrome, inability to articulate our own worth) highlights our strengths (our passion, our empathy, our problem solving ability, our practical and technical skills), diminishes the threats (seen as a support or an admin role in the rapidly changing digital landscape) and raises the importance and credibility (Kouzes & Posner, 2007) of the role and the work that we do promoting and enhancing digital pedagogy in higher education. It is precisely the work undertaken as third space professionals: implementing strategy as agents of change, working effectively with diverse people and disciplines, that develops the skills required to be leaders in higher education today (Denney, 2022, pp11; Pontefract, 2104 as cited in Loftus, 2018).

The proposed model highlights the value we bring to our institutions and pinpoints where we can and should take the lead in designing and supporting digital pedagogy. The model also benefits those women in and aspiring to be in leadership by illustrating that the strengths and opportunities as well as perceived threats and weaknesses of the third space female professional, place us well for contemporary leadership in higher education.

This digital poster will be interactive, inviting other women leaders to reflect on their strengths, weaknesses, opportunities, threats and to contribute to our model.
Adipose inflammation: South Asian ethnicity and central obesity are independently associated with higher immune cell recruitment to adipose‐specific media: A pilot study in men
Authors: Roberts Matthew J. , Hamrouni Malik , Wadley Alex J. , Bishop Nicolette C. 
Published: November 2023

AbstractA South Asian (SA) cardiovascular phenomenon exists whereby SAs have excess burden of cardiovascular disease (CVD) despite having low prevalence of recognized CVD risk factors. The aim of the current study was to determine whether perturbations in monocyte biology contribute to this phenomenon via higher circulating cell numbers, a more pro‐inflammatory phenotype, and higher transmigration and adhesion. Adhesion is linked to vascular inflammation whereas transmigration is linked to tissue inflammation. SA men with (N = 10; SAs with central obesity [CO‐SA]) and without (N = 10; lean SA [LE‐SA]) central obesity, plus White European counterparts (N = 10; white Europeans with central obesity [CO‐WE], N = 10; lean white Europeans [LE‐WE]) participated. An ex vivo assay mimicking blood flow dynamics coupled to flow cytometry determined the adhesion and transmigration of monocyte subsets toward chemokine‐rich media cultured from pre‐adipocytes (absolute responses). Migration and adhesion were also standardized for differences in numbers of circulating monocytes between participants (relative responses). Metabolic and inflammatory markers were assessed. SAs had higher absolute (but not relative) adhesion and migration of monocytes than WEs. Central obesity was associated with higher absolute and relative adhesion and migration of monocytes. SAs had higher concentrations of all monocyte subsets compared with WEs coinciding with adverse cardiovascular‐inflammatory profiles. LE‐SAs had similar monocyte concentrations, transmigration, and adhesion compared with CO‐WEs, corresponding with similar cardiovascular‐inflammatory profiles. The study provides novel evidence for higher monocyte counts associated with higher transmigration and adhesion in SA compared with WE men. Importantly, similar monocyte biology and cardiovascular‐inflammatory profiles were seen in LE‐SAs compared with CO‐WEs, which may contribute to the higher risk of CVD at lower body mass index experienced by SAs.
Use of point-of-care glucometers during an oral glucose tolerance test in children for prediabetes and diabetes diagnosis: a comparison study
Authors: Fabre-Estremera Blanca , Martínez-Chávez Estéfani , Manzano Ocaña Marta , Carcavilla Urquí Atilano , Morales Sánchez María de los Ángeles , Pinilla Tejado Inmaculada , González-Casado Isabel , Losantos García Itsaso , Fernández-Calle Pilar , Buño Soto Antonio , Oliver Paloma 
Published: November 2023

Abstract

Objectives
Despite clinical guidelines do not recommend the use of point-of-care testing (POCT) glucometers for diagnostic purposes yet, the analytical performance is continuously improving. Thus, we evaluate the technical accuracy and clinical concordance of POCT glucometers during an oral glucose tolerance test (OGTT) in children for prediabetes and diabetes diagnosis in a comparison study.

Methods
Pediatric patients with an OGTT indication who attended the Diabetes Unit between December 2020 and September 2021 were recruited for this prospective observational study. During the functional test, glycaemia was immediately measured in venous blood using two glucometers (unconnected and connected) and sent to the central laboratory.

Results
The study included 98 patients. There was a high correlation between the glucometers and the central laboratory (Pearson correlation coefficient=0.912 and 0.950, for unconnected and connected glucometer, respectively). The median OGTT turnaround time (TAT) was significantly decreased (connected glucometer: 2.02 h [interquartile range, 2.00–2.07], central laboratory: 11.63 h [6.09–25.80]), with similar overall cost. The diagnostic concordance between connected glucometer and the central laboratory was 71.1 % (95 % confidence interval (CI) 61.5–79.2). The clinical decision would have been the same in the 92.8 % of the cases, but treatment would have not been indicated in 4 patients (4.1 %).

Conclusions
POCT glucometers have demonstrated a high correlation and an acceptable diagnostic concordance with the central laboratory during an OGTT, as well the connected device offers a significant decrease in TAT, without increasing costs. However, as severe clinical impact could happen, POCT glucometers may not be used for diagnosis yet.