bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical application of 99mTc‐labeled peptides for tumor imaging: Current status and future directions
Authors: Shi Jiyun , Liu Shuang 
Published: January 2024

AbstractTargeting receptors overexpressed on cancer cells with radiolabeled peptides has become a crucial aspect of molecular imaging in oncology. Small peptides offer favorable characteristics for tumor targeting with minimal side effects and toxicity owing to their small size and simple radiolabeling protocols. Among them, somatostatin analogs have received regulatory approval for the diagnosis and treatment of neuroendocrine tumors. Cyclic RGD (Arg‐Gly‐Asp) peptides, bombesin analogs, and glucagon‐like peptide‐1 analogs are currently under development and/or undergoing clinical trials. The most used radionuclides for tumor imaging include 99mTc and 111In for single‐photon emission computed tomography, 68Ga and 18F for positron emission tomography. This review highlights the clinical potential and future prospects of 99mTc‐labeled peptides for tumor imaging.
Improving network data security interaction methods under wireless communication
Authors: Geng Jiali 
Published: January 2024

AbstractWith the development of information technology, network data security issues have received widespread attention. Under traditional wired communication networks, it not only has high installation and maintenance costs, requires a lot of manpower and resources, but also has low security performance, which is not significant in improving network data security. How to improve network data security, prevent data from being maliciously leaked, stolen, and effectively transmitted in the network, is a major challenge facing today's society. Wireless communication technology has brought new ideas to improve network data security. This article analyzed the role of wireless communication technology in improving network data security and selected 30 enterprises as the research objects. This article studied the role of traditional wired communication technology and wireless communication technology in network data security protection and compared several indicators based on virus detection rate, defense rate, data transmission speed, and customer satisfaction. The experimental results showed that the average detection rate of Trojan viruses based on wireless communication technology was 80.8%, and the average defense rate against viruses using antivirus software was 58%. In the case of virus attacks, the average transmission speed was 2.4 s, and the average satisfaction of users with wireless communication technology in virus defense was 6.9. It indicates that wireless communication technology has significantly improved virus detection rate, defense rate, data transmission speed, and customer satisfaction in the mode of improving network data security. This technology has significant significance and value for users.
MRASin coronary artery disease—Unchartered territory
Authors: Shah Pashmina Wiqar , Reinberger Tobias , Hashmi Satwat , Aherrahrou Zouhair , Erdmann Jeanette 
Published: January 2024

AbstractGenome‐wide association studies (GWAS) have identified coronary artery disease (CAD) susceptibility locus on chromosome 3q22.3. This locus contains a cluster of several genes that includes muscle rat sarcoma virus (MRAS). CommonMRASvariants are also associated with CAD causing risk factors such as hypertension, dyslipidemia, obesity, and type II diabetes. TheMRASgene is an oncogene that encodes a membrane‐bound small GTPase. It is involved in a variety of signaling pathways, regulating cell differentiation and cell survival (mitogen‐activated protein kinase [MAPK]/extracellular signal‐regulated kinase and phosphatidylinositol 3‐kinase) as well as acute phase response signaling (tumor necrosis factor [TNF] and interleukin 6 [IL6] signaling). In this review, we will summarize the role of geneticMRASvariants in the etiology of CAD and its comorbidities with the focus on tissue distribution ofMRASisoforms, cell type/tissue specificity, and mode of action of single nucleotide variants inMRASassociated complex traits. Finally, we postulate that CAD risk variants in theMRASlocus are specific to smooth muscle cells and lead to higher levels ofMRAS, particularly in arterial and cardiac tissue, resulting in MAPK‐dependent tissue hypertrophy or hyperplasia.
Study of ischemic progression in different intestinal tissue layers during acute intestinal ischemia using swept‐source optical coherence tomography angiography
Authors: Tian Yu , Zhang Mingshuo , Man Hongbo , Wu Chunnan , Wang Yimin , Kong Linghui , Liu Jian 
Published: January 2024

AbstractIn acute intestinal ischemia, the progression of ischemia varies across different layers of intestinal tissue. We established a mouse model and used swept‐source optical coherence tomography (OCT) to observe the intestinal ischemic process longitudinally in different tissue layers. Employing a method that combines asymmetric gradient filtering with adaptive weighting, we eliminated the vessel trailing phenomenon in OCT angiograms, reducing the confounding effects of superficial vessels on the imaging of deeper vasculature. We quantitatively assessed changes in vascular perfusion density (VPD), vessel length, and vessel average diameter across various intestinal layers. Our results showed a significant reduction in VPD in all layers during ischemia. The mucosa layer experienced the most significant impact, primarily due to disrupted capillary blood flow, followed by the submucosa layer, where vascular constriction or decreased velocity was the primary factor.
Advancements in 3D‐printed artificial tendon
Authors: Alhaskawi Ahmad , Zhou Haiying , Dong Yanzhao , Zou Xiaodi , Ezzi Sohaib Hasan Abdullah , Kota Vishnu Goutham , Abdulla Mohamed Hasan Abdulla , Tu Tian , Alenikova Olga , Abdalbary Sahar , Lu Hui 
Published: January 2024

AbstractMillions of people have been reported with tendon injuries each year. Unfortunately, Tendon injuries are increasing rapidly due to heavy exercise and a highly aging population. In addition, the introduction of 3D‐printing technology in the area of tendon repair and replacement has resolved numerous issues and significantly improved the quality of artificial tendons. This advancement has also enabled us to explore and identify the most effective combinations of biomaterials that can be utilized in this field. This review discusses the recent development of the 3D‐printed artificial tendon; where recently, some research investigated the most suitable pore sizes, diameter, and strength for scaffolds to have high tendon cells ingrowth and proliferation, giving a better understanding of the effects of densities and structure patterns on tendon's mechanical properties. In addition, it presents the divergence between 3D‐printed tendons and other tissue and how the different 3D‐printing techniques and models participated in this development.
Rethinking social assistance amid the COVID‐19 pandemic: Guaranteeing the right to income security in Ecuador
Authors: Jara H. Xavier , Palacio Ludeña María Gabriela 
Published: January 2024

AbstractIn the face of increased uncertainty and a slow economic recovery, it is crucial to protect populations from the effects of systemic crises beyond the narrow goal of poverty reduction. In Ecuador, social assistance programs had little effect in reducing earnings losses caused by the COVID‐19 pandemic, leading to a renewed discussion on the implementation of a universal basic income (UBI). This study evaluates the potential impact of social assistance reforms using tax‐benefit microsimulation techniques. Four simulated counterfactual reforms are assessed, ranging from an extension of current social assistance programs to the implementation of UBI, which would replace existing programs and be partially funded through progressive personal income tax and social security contributions. Our findings demonstrate that poverty and inequality would decrease significantly under the more generous UBI scenarios. This research contributes to the ongoing debate on the potential benefits of UBI in reducing poverty and inequality and emphasizes the importance of considering alternative social assistance reforms in the face of growing systemic challenges.
Using Porter's Five Forces analysis to drive strategy
Authors: Pangarkar Nitin , Prabhudesai Rohit 
Published: January 2024

AbstractThis paper aims to provide practical pointers to scholars, students, and practitioners about applying Porter's Five Forces analysis, a longstanding, comprehensive, and practical framework in strategic analysis. The paper combines two methodologies: a review of prior studies and the inductive methodology. The latter involved drawing on examples from different industries and contexts, specifically the Indian passenger car industry. The elaboration of the subtleties and contextual factors and identification of specific pointers in this paper will help managers understand the critical aspects of their environments and formulate an appropriate strategy for their context.
Spectroscopic assessment of biomolecular changes inHelicobacter pyloriand Epstein–Barr virus co‐infected gastric epithelial cells
Authors: Kashyap Dharmendra , Tanwar Manushree , Rani Chanchal , Bagde Pranit Hemant , Singh Siddharth , Varshney Nidhi , Saini Vaishali , Mishra Amit , Kumar Rajesh , Jha Hem Chandra 
Published: January 2024

AbstractHelicobacter pyloriand Epstein–Barr Virus (EBV) are Group 1 carcinogens that can enhance gastric cancer progression. Bioactive substances extracted from plants can be effective therapeutic agents in cancer treatment. For example,Withania somniferaextract‐WSE reduces the Gankyrin oncoprotein, which is upregulated in the presence ofH. pyloriand EBV. The various biochemical and metabolic changes upon 24 hrs post‐infection followed byW. somniferaextract (WSE) treatment on gastric epithelial cells (AGS) can be studied using spectroscopic techniques. In the biomedical sciences, Raman and NMR spectroscopy have been extensively employed to interpret cellular alterations contributing to the onset of infection and the severity of gastric cancer. More specifically, alterations in cellular biochemical homeostasis are linked to the moieties of cholesterol, collagen, choline, carbohydrate, lipids, tyrosine, and phenylalanine. Further, we have found significantly elevated FWHM for carbohydrates, tumor associated protein, collagen, cholesterol, and cholesterol ester in the co‐infection model. We also looked into the potential correlation between these molecules using molecular network analysis and found several related factors that can be modulated through biomolecular levels. These molecules are crucial in several physiological functions, including cell division, cell proliferation, apoptosis, necrosis, cell migration, and lipid transport. Our study paves the pathway to studyH. pyloriand EBV co‐infection in human gastric epithelial cells and the therapeutic interventions of WSE in this scenario and highlights specific biomolecular alterations, which can be focused for further mechanistic investigations.
Third‐generation sequencing identified two rare α‐chain variants leading to hemoglobin variants in Chinese population
Authors: Zhuang Jianlong , Jiang Yuying , Chen Yu'e , Mao Aiping , Chen Junwei , Chen Chunnuan 
Published: January 2024

AbstractBackgroundRare and novel variants of HBA1/2 and HBB genes resulting in thalassemia and hemoglobin (Hb) variants have been increasingly identified. Our goal was to identify two rare Hb variants in Chinese population using third‐generation sequencing (TGS) technology.MethodsEnrolled in this study were two Chinese families from Fujian Province. Hematological screening was conducted using routine blood analysis and Hb capillary electrophoresis analysis. Routine thalassemia gene testing was carried out to detect the common mutations of α‐ and β‐thalassemia in Chinese population. Rare or novel α‐ and β‐globin gene variants were further investigated by TGS.ResultsThe proband of family 1 was a female aged 32, with decreased levels of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), Hb A2, and abnormal Hb bands in zone 5 and zone 12. No common thalassemia mutations were detected by routine thalassemia analysis, while a rare α‐globin gene variant Hb Jilin [α139(HC1)Lys>Gln (AAA>CAA); HBA2:c.418A>C] was identified by TGS. Subsequent pedigree analysis showed that the proband's son also harbored the Hb Jilin variant with slightly low levels of MCH, Hb A2, and abnormal Hb bands. The proband of family 2 was a male at 41 years of age, exhibiting normal MCV and MCH, but a low level of Hb A2 and an abnormal Hb band in zone 12 without any common α‐ and β‐thalassemia mutations. The subsequent TGS detection demonstrated a rare Hb Beijing [α16(A14)Lys>Asn (AAG>AAT); HBA2:c.51G>T] variant in HBA2 gene.ConclusionIn this study, for the first time, we present two rare Hb variants of Hb Jilin and Hb Beijing in Fujian Province, Southeast China, using TGS technology.
Element‐free Galerkin method for a fractional‐order boundary value problem
Authors: Rajan Akshay , Desai Shubham , Sidhardh Sai 
Published: January 2024

AbstractIn this article, we develop a meshfree numerical solver for fractional‐order governing differential equations. More specifically, we develop a mesh‐free interpolation‐based element‐free Galerkin numerical model for the fractional‐order governing differential equations. The proposed fractional element‐free Garlekin (f‐EFG) numerical model is a lighter and more accurate alternative to existing mesh‐based finite element solvers for the fractional‐order governing differential equations. We demonstrate here that the f‐EFG with moving least squares (MLS) interpolants are naturally suitable for the approximation of fractional‐order derivatives in terms of the corresponding nodal values, thereby alleviating several issues with FE solvers for such integro‐differential governing equations. We demonstrate the efficacy of the proposed numerical model for numerical solutions with benchmark problems on the linear and nonlinear elastic response of nonlocal elastic solid modeled via fractional‐order governing differential equations. However, it must be noted that the proposed f‐EFG algorithm can be extended to fractional‐order governing differential equations in diverse applications, including multiscale and multiphysics studies.
Coverage and determinants of infant postnatal care in Nigeria: A population‐based cross‐sectional study
Authors: Egbewale Bolaji Emmanuel , Oyedeji Olusola , Bump Jesse , Sudfeld Christopher Robert 
Published: January 2024

ABSTRACTImportanceIn 2019, Nigeria had the largest number of under‐5 child deaths globally and many of these deaths occurred within the first week of life. The World Health Organization recommends infant postnatal care (PNC) attendance to support newborn survival; however, utilization of PNC is known to be low in many contexts.ObjectiveThis study examined coverage and individual‐level determinants of infant PNC attendance in Nigeria.MethodsNigeria Demographic Health Survey (NDHS) 2018 data were used to evaluate infant PNC coverage and determinants. Infant PNC was defined as receipt of care within 2 days of birth. Children delivered up to 2 years before the 2018 NDHS were included. We examined predictors of infant PNC with modified Poisson regression models to estimate relative risks (RRs).ResultsThe national coverage of infant PNC was 37.3% (95% confidence interval [CI]: 35.8%–38.7%). Significant heterogeneity in PNC attendance existed at state and regional levels. Facility delivery was strongly associated with the uptake of PNC (RR: 6.07; 95% CI: 5.60–6.58). Greater maternal education, maternal employment, urban residence, female head of household, and greater wealth were also associated with an increased likelihood of PNC visits.InterpretationThe uptake of infant PNC is low and interventions are urgently needed to promote equity in access and increase demand for PNC in Nigeria.
Quantized stabilizing control of state‐dependent switching affine systems with control‐input and state‐measurement quantization
Authors: Cai Bo , Ning Zepeng , Cheng Yiming , Tian Yongxiao , Chen Guoliang 
Published: January 2024

AbstractThis paper addresses stability analysis and quantized stabilization of discrete‐time state‐dependent switching affine systems with quantized control inputs and state measurements. The employed controller is in a mode‐dependent affine form to improve the adaptation to the mode of the controlled system and then to acquire less conservative results. The quantization scheme is considered to be logarithmic and synchronized with the mode switching of the switching affine system and the controller. Aiming at achieving lower conservative criteria, a mode‐dependent Lyapunov function incorporating quantization uncertainties is constructed. Correspondingly, the stability analysis and the stabilizing control synthesis are implemented. In the end, the proposed quantized control strategy is applied to a vehicle path‐following problem to exemplify its effectiveness and robustness against data quantization in control inputs and state measurements.
FMCW Radar on LiDAR map localization in structural urban environments
Authors: Ma Yukai , Li Han , Zhao Xiangrui , Gu Yaqing , Lang Xiaolei , Li Laijian , Liu Yong 
Published: January 2024

AbstractMultisensor fusion‐based localization technology has achieved high accuracy in autonomous systems. How to improve the robustness is the main challenge at present. The most commonly used LiDAR and camera are weather‐sensitive, while the frequency‐modulated continuous wave Radar has strong adaptability but suffers from noise and ghost effects. In this paper, we propose a heterogeneous localization method called Radar on LiDAR Map, which aims to enhance localization accuracy without relying on loop closures by mitigating the accumulated error in Radar odometry in real time. To accomplish this, we utilize LiDAR scans and ground truth paths as Teach paths and Radar scans as the trajectories to be estimated, referred to as Repeat paths. By establishing a correlation between the Radar and LiDAR scan data, we can enhance the accuracy of Radar odometry estimation. Our approach involves embedding the data from both Radar and LiDAR sensors into a density map. We calculate the spatial vector similarity with an offset to determine the corresponding place index within the candidate map and estimate the rotation and translation. To refine the alignment, we utilize the Iterative Closest Point algorithm to achieve optimal matching on the LiDAR submap. The estimated bias is subsequently incorporated into the Radar SLAM for optimizing the position map. We conducted extensive experiments on the Mulran Radar Data set, Oxford Radar RobotCar Dataset, and our data set to demonstrate the feasibility and effectiveness of our proposed approach. Our proposed scan projection descriptors achieves homogeneous and heterogeneous place recognition and works much better than existing methods. Its application to the Radar SLAM system also substantially improves the positioning accuracy. All sequences' root mean square error is 2.53 m for positioning and 1.83° for angle.
Photothermal Conversion of the Oleophilic PVDF/Ti3C2Tx Porous Foam Enables Non‐Aqueous Liquid System Applicable Actuator
Authors: Chen Ruoqi , Zhang Huanrong , Du Yuhang , Ma Hui , Ma Xinlei , Ji Junhui , Wang Xusheng , Xue Mianqi 
Published: January 2024

AbstractVarious physical and chemical reaction processes occur in non‐aqueous liquid systems, particularly in oil phase systems. Therefore, achieving efficient, accurate, controllable, and cost‐effective movement and transfer of substances in the oil phase is crucial. Liquid‐phase photothermal actuators (LPAs) are commonly used for material transport in liquid‐phase systems due to their remote operability and precise control. However, existing LPAs typically rely on materials like hydrogels and flexible polymers, commonly unsuitable for non‐aqueous liquids. Herein, a 3D porous poly(vinylidene fluoride) (PVDF)/Ti3C2Tx actuator is developed using a solvent displacement method. It demonstrates directional movement and controlled material transport in non‐aqueous liquid systems. When subject to infrared light irradiation (2.0 W cm−2), the actuator achieves motion velocities of 7.3 and 6 mm s−1 vertically and horizontally, respectively. The actuator's controllable motion capability is primarily attributed to the foam's oil‐wettable properties, 3D porous oil transport network, and the excellent photothermal conversion performance of Ti3C2Tx, facilitating thermal diffusion and the Marangoni effect. Apart from multidimensional directions, the actuator enables material delivery and obstacle avoidance by transporting and releasing target objects to a predetermined position. Hence, the developed controllable actuator offers a viable solution for effective motion control and material handling in non‐aqueous liquid environments.
General Introduction
Authors: Hofstetter Rita , Schneuwly Bernard 
Published: January 2024

AbstractFirst, we show that the IBE, founded in 1925, can be considered as a matrix of educational internationalism. It became the first intergovernmental institution in education in 1929, and under the aegis of Piaget, it developed a more and more resolutely universal and universalist ambition. This orientation of the IBE sets the point of view adopted for the analysis of its history.We then forge theoretical tools based on the ongoing debate on the universal in order to proceed to a critical sociogenesis of the IBE’s ambitions and achievements within its relational network and the educational context of the twentieth century and we formulate our research questions.We finally present the five parts which make up the book, each representing a particular point of view on the IBE’s history, written thanks to the rich archival heritage which is briefly described. A brief conclusion highlights some contradictions still present today which are then taken up in our general conclusion.
Challenging the Institutional Politics of Life in the Making of Refused Knowledge
Authors: Crabu Stefano 
Published: January 2024

AbstractRefused knowledge communities (RKCs) can be analytically framed as specific social worlds, in the context of which questioning science-related epistemic, professional, and political arrangements is a crucial dimension of mutual concern. Hence, understanding refused knowledge followers’ attitudes to biomedical theories and their part in public health and healthcare systems and professional healthcare practice is urgent if we are to cast light on the conditions nurturing the legitimacy of knowledge emerging outside the boundaries of science. Against this backdrop, the aim of this chapter is to shed light on how RKCs engage in a contentious relationship with the conditions under which biomedical knowledge is shaped and mobilised by health professionals. In so doing, it elucidates how these contentious dynamics are entangled with the ways in which RKCs confer credibility and reliability on refused knowledge itself. Indeed, RKCs are not merely concerned with challenging the content of scientific and biomedical knowledge. They also question its epistemic, professional, and economic roots, that is, RKCs argue that claims and knowledge elaborated and enacted in the context of biomedicine, and the life sciences in general, are enmeshed with specific social, political, and material interests, and therefore either not to be believed or at least treated with scepticism.