bluuebunny/crossref_metadata_2025_split huggingface dataset:
The feasibility of a multidimensional intervention in lymphoma survivors with chronic fatigue
Authors: Bøhn SKH , Oldervoll LM , Reinertsen KV , Seland M , Fosså A , Kiserud C , Skaali T , Nilsen TS , Blomhoff R , Henriksen HB , Lie HC , Berge T , Fjerstad E , Wisløff T , Slott M , Zajmovic I , Thorsen L 
Published: December 2023

Abstract
Purpose
Chronic fatigue (CF) affects 25–30% of lymphoma survivors, but interventions designed to reduce fatigue are lacking. The main aim of this study was to test the feasibility of a multidimensional intervention study in lymphoma survivors with CF. Secondary aims were to describe individual changes in fatigue, quality of life (QoL) and physical performance from pre (T0) to post (T1) intervention.

Methods
This feasibility study was as a one-armed intervention study performed in 2021. Hodgkin or aggressive non-Hodgkin lymphoma survivors received mailed study information and Chalder Fatigue Questionnaire and were asked to respond if they suffered from fatigue. The 12-week intervention included patient education, physical exercise, a cognitive behavioural therapy (CBT)-based group program and nutritional counselling. Feasibility data included patient recruitment, completion of assessments, adherence to the intervention and patient-reported experience measures. Participants responded to questionnaires and underwent physical tests at T0 and T1.

Results
Seven lymphoma survivors with CF were included. Of all assessments, 91% and 83% were completed at T0 and T1, respectively. Adherence to the interventional components varied from 69% to 91%. At T1, all participants rated exercise as useful, of whom five rated the CBT-based program and five rated individual nutritional counselling as useful. Five participants reported improved fatigue, QoL and physical performance.

Conclusion
Lymphoma survivors with CF participating in a multidimensional intervention designed to reduce the level of fatigue showed high assessment completion rate and intervention adherence rate. Most of the participants evaluated the program as useful and improved their level of fatigue, QoL and physical performance after the intervention.

Trial registration
ClinicalTrials.gov, identifier: NCT04931407. Registered 16. April 2021-Retrospectively registered. https://www.clinicaltrials.gov/ct2/show/NCT04931407
Handling uncertainty issue in software defect prediction utilizing a hybrid of ANFIS and turbulent flow of water optimization algorithm
Authors: Elsabagh M. A. , Emam O. E. , Gafar M. G. , Medhat T. 
Published: December 2023

AbstractDuring the development cycle of software projects, numerous defects and challenges have been identified, leading to prolonged project durations and escalated costs. As a result, both product delivery and defect tracking have become increasingly complex, expensive, and time-consuming. Recognizing the challenge of identifying every software defect, it is crucial to foresee potential consequences and strive for the production of high-quality products. The goal of software defect prediction (SDP) is to identify problematic locations within software code. This study presents the first experimental investigation utilizing the turbulent flow of water optimization (TFWO) in conjunction with the adaptive neuro-fuzzy inference system (ANFIS) to enhance SDP. The TFWO_ANFIS model is designed to address the uncertainties present in software features and predict defects with feasible accuracy. Data are divided randomly at the beginning of the model into training and testing sets to avoid the local optima and over-fitting issues. By applying the TFWO approach, it adjusts the ANFIS parameters during the SDP process. The proposed model, TFWO_ANFIS, outperforms other optimization algorithms commonly used in SDP, such as particle swarm optimization (PSO), gray wolf optimization (GWO), differential evolution (DE), ant colony optimization (ACO), standard ANFIS, and genetic algorithm (GA). This superiority is demonstrated through various evaluation metrics for four datasets, including standard deviation (SD) scores (0.3307, 0.2885, 0.3205, and 0.2929), mean square error (MSE) scores (0.1091, 0.0770, 0.1026, and 0.0850), root-mean-square error (RMSE) scores (0.3303, 0.2776, 0.3203, and 0.2926), mean bias error (MBE) scores (0.1281, 0.0860, 0.0931, and 0.2310), and accuracy scores (87.3%, 90.2%, 85.8%, and 89.2%), respectively, for the datasets KC2, PC3, KC1, and PC4. These datasets with different instances and features are obtained from an open platform called OPENML. Additionally, multiple evaluation metrics such as precision, sensitivity, confusion matrices, and specificity are employed to assess the model’s performance.
Multidrug-resistant Gram-negative clinical isolates with reduced susceptibility/resistance to cefiderocol: which are the best present and future therapeutic alternatives?
Authors: Le Terrier Christophe , Freire Samanta , Nordmann Patrice , Poirel Laurent 
Published: December 2023

Abstract
Purpose
To evaluate the different present and future therapeutic β-lactam/β-lactamase inhibitor (BL/BLI) alternatives, namely aztreonam-avibactam, imipenem-relebactam, meropenem-vaborbactam, cefepime-zidebactam, cefepime-taniborbactam, meropenem-nacubactam, and sulbactam-durlobactam against clinical isolates showing reduced susceptibility or resistance to cefiderocol in Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa.

Methods
MIC values of aztreonam, aztreonam-avibactam, cefepime, cefepime-taniborbactam, cefepime-zidebactam, imipenem, imipenem-relebactam, meropenem, meropenem-vaborbactam, meropenem-nacubactam, sulbactam-durlobactam, and cefiderocol combined with a BLI were determined for 67, 9, and 11 clinical Enterobacterales, P. aeruginosa or A. baumannii isolates, respectively, showing MIC values of cefiderocol being ≥1 mg/L. If unavailable, the respective β-lactam breakpoints according to EUCAST were used for BL/BLI combinations.

Results
For Enterobacterales, the susceptibility rates for aztreonam, cefepime, imipenem, and meropenem were 7.5%, 0%, 10.4%, and 10.4%, respectively, while they were much higher for cefepime-zidebactam (91%), cefiderocol-zidebactam (91%), meropenem-nacubactam (71.6%), cefiderocol-nacubactam (74.6%), and cefiderocol-taniborbactam (76.1%), as expected. For P. aeruginosa isolates, the higher susceptibility rates were observed for imipenem-relebactam, cefiderocol-zidebactam, and meropenem-vaborbactam (56% for all combinations). For A. baumannii isolates, lower susceptibility rates were observed with commercially or under development BL/BLI combos; however, a high susceptibility rate (70%) was found for sulbactam-durlobactam and when cefiderocol was associated to some BLIs.

Conclusions
Zidebactam- and nacubactam-containing combinations showed a significant in vitro activity against multidrug-resistant Enterobacterales clinical isolates with reduced susceptibility to cefiderocol. On the other hand, imipenem-relebactam and meropenem-vaborbactam showed the highest susceptibility rates against P. aeruginosa isolates. Finally, sulbactam-durlobactam and cefiderocol combined with a BLI were the only effective options against A. baumannii tested isolates.
Hardness and approximation of submodular minimum linear ordering problems
Authors: Farhadi Majid , Gupta Swati , Sun Shengding , Tetali Prasad , Wigal Michael C. 
Published: December 2023

AbstractThe minimum linear ordering problem (MLOP) generalizes well-known combinatorial optimization problems such as minimum linear arrangement and minimum sum set cover. MLOP seeks to minimize an aggregated cost $$f(\cdot )$$

f
(
·
)

due to an ordering $$\sigma $$
σ
of the items (say [n]), i.e., $$\min _{\sigma } \sum _{i\in [n]} f(E_{i,\sigma })$$

min
σ

∑

i
∈
[
n
]

f

(

E

i
,
σ

)

, where $$E_{i,\sigma }$$

E

i
,
σ

is the set of items mapped by $$\sigma $$
σ
to indices [i]. Despite an extensive literature on MLOP variants and approximations for these, it was unclear whether the graphic matroid MLOP was NP-hard. We settle this question through non-trivial reductions from mininimum latency vertex cover and minimum sum vertex cover problems. We further propose a new combinatorial algorithm for approximating monotone submodular MLOP, using the theory of principal partitions. This is in contrast to the rounding algorithm by Iwata et al. (in: APPROX, 2012), using Lovász extension of submodular functions. We show a $$(2-\frac{1+\ell _{f}}{1+|E|})$$

(
2
-

1
+

ℓ
f

1
+
|
E
|

)

-approximation for monotone submodular MLOP where $$\ell _{f}=\frac{f(E)}{\max _{x\in E}f(\{x\})}$$

ℓ
f

=

f
(
E
)

max

x
∈
E

f

(

{
x
}

)

satisfies $$1 \le \ell _f \le |E|$$

1
≤

ℓ
f

≤

|
E
|

. Our theory provides new approximation bounds for special cases of the problem, in particular a $$(2-\frac{1+r(E)}{1+|E|})$$

(
2
-

1
+
r
(
E
)

1
+
|
E
|

)

-approximation for the matroid MLOP, where $$f = r$$

f
=
r

is the rank function of a matroid. We further show that minimum latency vertex cover is $$\frac{4}{3}$$

4
3

-approximable, by which we also lower bound the integrality gap of its natural LP relaxation, which might be of independent interest.
A Row Displacement Correction Algorithm for High-speed and Accurate Terahertz Raster Scanning Imaging
Authors: Zhu Ting , Chen Hao , Liu Kai , Fang Guangyou , Chen Xuequan 
Published: December 2023

AbstractTerahertz time-domain spectroscopic imaging has become a common and useful technique for various interdisciplinary studies. Raster scan is still the most general and reliable imaging modality due to the lack of matrix detectors. In terahertz raster scanning imaging, row displacements occur due to the use of a two-way continuous scanning mode, the lack of delay line triggering, or other technical factors. The displacements result in image distortion which significantly affects the subsequent data analysis. In this article, a row displacement correction algorithm based on a genetic algorithm is proposed. The algorithm corrects images based on the principle that row displacements result in an increase of high-frequency components of the Fourier spectrum transformed along the image column direction. The algorithm performance is comprehensively verified by both numerical simulation and experimental data, showing a promising effectiveness and robustness on different sample types, shapes, orientations, and spatial distributions. The algorithm corrects the displacements numerically regardless of the causing factors, offering a wide adaptability for various THz systems to improve the scanning efficiency and image quality.
The ascending chain condition on principal right ideals for semigroup constructions
Authors: Miller Craig 
Published: December 2023

AbstractWe call a semigroup $${\mathcal {R}}$$
R
-noetherian if it satisfies the ascending chain condition on principal right ideals, or, equivalently, the ascending chain condition on $${\mathcal {R}}$$
R
-classes. We investigate the behaviour of the property of being $${\mathcal {R}}\text {-noetherian}$$

R
-noetherian

under the following standard semigroup-theoretic constructions: semidirect products, Schützenberger products, free products, Rees matrix semigroups, Brandt extensions, Bruck–Reilly extensions and semilattices of semigroups.
Improvement of motion artifacts using dynamic whole-body 18F-FDG PET/CT imaging
Authors: Kaji Tomohito , Osanai Kouji , Takahashi Atsushi , Kinoshita Atsushi , Satoh Daiki , Nakata Tomoaki , Tamaki Nagara 
Published: December 2023

Abstract
Purpose
Serial dynamic whole-body PET imaging is valuable for assessing serial changes in tracer uptake. The purpose of this study was to evaluate the improvement of motion artifacts in patients using serial dynamic whole-body 18F-fluorodeoxyglyucose (FDG) PET/CT imaging.

Materials and methods
In 797 consecutive patients, serial 3-min dynamic whole-body FDG PET imaging was performed seven times, at 60 or 90 min after FDG administration. In cases with large body motion during imaging, we tried to improve the images by summing the images before body motion. An image quality study was performed on another 50 patients without obvious body motion using the same acquisition mode.

Results
Obvious body movement was observed in 106 of 797 cases (13.3%), and severe motion artifacts which interfered image interpretation were observed in 18 (2.3%). In these 18 cases, summation of the images before the body movement enabled us to obtain images that excluded the effect of the body motion. In the visual evaluation of the image quality in another 50 patients studied, acceptable image quality was obtained when 2 or more times the serial 3-min image data were added.

Conclusion
Serial dynamic whole-body FDG PET imaging can minimize body motion artifacts by summation of the images before the body motion. Such serial dynamic study may be a choice for PET imaging to eliminate motion artifacts.
Solid tumours showing oligoprogression to immune checkpoint inhibitors have the potential for abscopal effects
Authors: Ito Makoto , Abe Souichiro , Adachi Sou , Oshima Yukihiko , Takeuchi Arisa , Ohashi Wataru , Iwata Takashi , Ogawa Tetsuya , Ota Akiko , Kubota Yasuaki , Okuda Takahito , Suzuki Kojiro 
Published: December 2023

Abstract
Purpose
Given the uncertainty surrounding the abscopal effect (AE), it is imperative to identify promising treatment targets. In this study, we aimed to explore the incidence of AE when administering radiotherapy to patients with oligoprogressive solid tumours while they are undergoing treatment with immune checkpoint inhibitors (ICIs).

Materials and methods
In this multicentre prospective observational study, oligoprogressive disease was defined as a < 20% increase in lesions compared to > 2 months before enrolment. We enrolled patients who requested radiotherapy during the ICI rest period between 2020 and 2023. AE was considered present if ≥ 1 non-irradiated lesion decreased by ≥ 30% before the next line of systemic therapy started.

Results
Twelve patients were included in this study; the common primary lesions were in the lungs (four patients) and kidneys (three patients). AEs were observed in six (50%) patients, with a median time to onset of 4 (range 2–9) months after radiotherapy. No significant predictors of AEs were identified. Patients in the AE group had a significantly better 1-year progression-free survival (PFS) rate than those in the non-AE group (p = 0.008). Two patients from the AE group were untreated and progression-free at the last follow-up. Four (33%) patients experienced grade 2 toxicity, with two cases attributed to radiotherapy and the other two to ICI treatment. No grade 3 or higher toxicities were observed in any category.

Conclusion
Patients with oligoprogressive disease may be promising targets with potential for AEs. AEs can lead to improved PFS and, in rare cases, to a certain progression-free period without treatment.

Secondary Abstract
Irradiating solid tumours in patients with oligoprogressive disease during immune checkpoint inhibitor therapy may be a promising target with the potential for abscopal effects (AEs). AEs can lead to improved progression-free survival and, in rare cases, to a certain progression-free period without treatment.
The Concept of De-assimilation: The Example of Jews in Poland
Authors: Krajewski Stanisław 
Published: December 2023

AbstractAfter the 1968 emigration, very few Jews remained in Poland, and even more miniscule was the number of “Jewish Jews.” Since then the number has grown somewhat, and much of it is due to the process of de-assimilation; i.e., some people with Jewish ancestors raised in completely Polonized families began to recover, reclaim, and readapt their Jewish background. An analysis of this phenomenon is offered with a series of putative reasons for its occurrence. The individuals constituting the “products” of de-assimilation are the majority of Polish Jews today and form much of the current leadership. While individuals everywhere can strengthen their ties to the Jewish people and can experience teshuvah or another kind of “Judaization,” the process of de-assimilation does not seem to be reducible to those moves. It begins with no Jewish identity, and is highly dependent on the attitudes and cultural trends in the majority society. It does not remove the de-assimilationists from the majority culture. The phenomenon is general and deserves to be studied as a sociological mechanism working in other cases of assimilation to a majority culture. In the Jewish case, it is especially dramatic. Probably the first example can be found in the evolution of the Marrano communities settled in Holland. The presence of de-assimilation seems to differentiate some European, first of all East European, communities from the globally dominant American and Israeli ones. Probably this rather new concept is needed to describe a significant part of the world of the Jews of twenty-first century Europe.
Averaged versus individualized: pragmatic N-of-1 design as a method to investigate individual treatment response
Authors: Serpico Davide , Maziarz Mariusz 
Published: December 2023

AbstractHeterogeneous treatment effects represent a major issue for medicine as they undermine reliable inference and clinical decision-making. To overcome the issue, the current vision of precision and personalized medicine acknowledges the need to control individual variability in response to treatment. In this paper, we argue that gene-treatment-environment interactions (G × T × E) undermine inferences about individual treatment effects from the results of both genomics-based methodologies—such as genome-wide association studies (GWAS) and genome-wide interaction studies (GWIS)—and randomized controlled trials (RCTs). Then, we argue that N-of-1 trials can be a solution to overcome difficulties in handling individual variability in treatment response. Although this type of trial has been suggested as a promising strategy to assess individual treatment effects, it nonetheless has limitations that limit its use in everyday clinical practice. We analyze the existing variability within the designs of N-of-1 trials in terms of a continuum where each design prioritizes epistemic and pragmatic considerations. We then support wider use of the designs located at the pragmatic end of the explanatory-pragmatic continuum.
Investigation of the confinement effect on fluid-phase behavior in shale oil reservoirs during CO2 injection process
Authors: Dou Xiangji , Zhang Yisong , Guo Jing , Qian Kun 
Published: December 2023

AbstractDue to the confinement effect of nanopores, the fluid-phase behavior of shale oil reservoirs is much different from that of conventional reservoirs. The accurate description of the phase change characteristics of fluid in nanopores is the basis to design development plan, production system, and EOR methods of shale oil reservoirs. In this study, molecular dynamics simulation was employed to analyze the phase behavior of single-component system and hydrocarbon–CO2 mixture system in organic nanopores. The results show that the confinement effect on the phase change pressure of the single-component system is influenced by the distribution of the electron cloud. The phase change pressure of hydrocarbons with even distribution of the electron cloud would be increased, while that of CO2 would be decreased due to the instantaneous dipole moment. In addition, as the length of carbon chains increases, the confinement effect on hydrocarbons becomes stronger. When the temperature increases, the confinement effect becomes weaker. In the hydrocarbon–CO2 mixture system, when the occurrence condition changes from bulk to the nanopore of 5 nm, the bubble point pressure decreases by 39.21–68.85%, and the critical temperature and pressure decrease by 75.98% and 7.13%, respectively. On the whole, the P–T phase envelope is shrunken under the confinement effect. CO2 is much easier to be miscible with shale oil in nanopores. Moreover, full mixing and keeping in single liquid phase of CO2–hydrocarbons mixture system can reduce the adsorption of hydrocarbons on organic pore walls. Therefore, CO2 injection could be a feasible method to enhance oil recovery in the matrix of shale oil reservoirs.
Shaping climate change discourse: the nexus between political media landscape and recommendation systems in social networks
Authors: Sakieh Yousef 
Published: December 2023

Abstract
Recommendation systems have become ubiquitous, and they actively participate in creating our individual and collective identity. In this paper, the diffusion of climate change information has been studied based on YouTube’s recommendation system and the political media landscape. The YouTube channels of CNN, BBC News and Fox News, as the most popular channels, respectively, for Left, Center and Right parties, were explored using web scraping and social network analysis to check what kind of recommended content will pop up if a user looks for climate change videos. Using an agent-based modeling approach, the competition between Left, Center and Right media in pushing their own narrative of climate change in society was simulated. The results suggest YouTube’s recommendation algorithm is highly biased since most of the recommended content was from the same channel fitting their own political agenda. The agent-based modeling indicates the size of a network is a decisive factor in further spread of a message as Left media always dominated Center and Right media in pushing their own perspective on climate change regardless of higher weights assigned to Right media. This study shed light on how public perception on climate change can be shaped by recommendation systems and digital companies.
Clinical phenotype and outcome of persistent SARS-CoV-2 replication in immunocompromised hosts: a retrospective observational study in the Omicron era
Authors: Götz Veronika , Mathé Philipp , Agarwal Prerana , Hornuss Daniel , Pfau Stefanie , Panning Marcus , Prager Eric , Voll Reinhard E. , Engelhardt Monika , Frye Björn C. , Bamberg Fabian , Fuchs Jonas , Müller Matthias , Wagner Dirk , Rieg Siegbert 
Published: December 2023

Abstract
Purpose
This study aims to describe clinical, virological and radiological characteristics as well as treatment strategies and outcomes of immunocompromised patients with persistent SARS-CoV-2 replication.

Methods
We performed a retrospective cohort study of immunocompromised patients at the University Medical Center Freiburg between 01/2022 and 05/2023. Patients with substantial immunosuppression and persistent SARS-CoV-2 detection (Ct-value < 30 after 14 days) were included.

Results
36 patients in our cohort reported mainly fever, dyspnoea or continuous cough. Viral load was significantly higher in concurrent samples taken from the lower respiratory tract (Ct-value = 26) than from the upper respiratory tract (Ct-value = 34). Time of detectable viral RNA after start of antiviral treatment was shorter in patients receiving two antivirals (median 15 days vs. 31 days with one antiviral agent). Short-course antiviral therapy (≤ 5 days) was less efficient in reduction of symptoms and viral load than prolonged therapy > 10 days. In 30% (8/27) of patients with repeated CT scans, we found the emergence of chronic pulmonary changes, which were more frequently in patients with B cell depletion (37%, 7/19) compared to patients with organ transplantation (12%, 2/17).

Conclusion
Ongoing SARS-CoV-2 replication in the lower respiratory tract is a relevant differential diagnosis in patients with severe immunosuppression and continuous cough, fever or dyspnoea even if nasopharyngeal swabs test negative for SARS-CoV-2. Especially in B cell-depleted patients, this may lead to inflammatory or fibrotic-like pulmonary changes, which are partially reversible after inhibition of viral replication. Antiviral therapy seems to be most effective in combination and over a prolonged period of time of > 10 days.

Trial registration number
DRKS 00027299.