bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uji antiinflamasi krim ekstrak daun teratai (Nymphae Pusbescens Willd) terhadap penyembuhan luka
Authors: Saputri Aisyah Sari , Husna Putri Nadhifatul , Maghfiroh Ilvi , Nurmahmudah Siti , Endartiwi Sri Sularsih 
Published: January 2024

Teratai (Nymphaea pubescens L.) adalah tanaman yang belum dimaksimalkan manfaatnya sebagai tanaman obat. Teratai memiliki manfaat untuk menyembuhkan berbagai penyakit. Hampir semua bagian dari tanaman ini dapat dimanfaatkan. Tujuan penelitian ini untuk menganalisa konsentrasi ekstrak daun teratai yang paling optimum dalam menyembuhkan hewan uji dengan mengaplikasikan daun teratai sebagai obat krim luka sayat dan luka bakar dengan variasi konsentrasi ekstrak daun teratai. Metode yang digunakan adalah metode uji antiinflamasi in-vivo terhadap 30 ekor tikus putih (Rattus Novergicus) Galur Wistar yang dibagi menjadi 5 kelompok untuk variasi konsentrasi kontrol positif dan kontrol negatif. Pengolesan dilakukan secara merata 2 kali setiap pagi sore lalu diamati dan diukur panjang luas penutupan luka selama 21 hari, kemudian data diolah secara statistik menggunakan SPSS. Hasil penelitian menunjukkan bahwa sediaan krim ekstrak daun teratai (Nymphaea Pubescens L.) dosis konsentras 6% memiliki respon kesembuhan peradangan paling cepat kelompok hewan uji luka sayat konsentrasi 6% dengan persentase kesembuhan luka sayat sebesar 100% dan luka bakar sebesar 18,98% hingga perlakuan hari ke-21 yang mendekati efek obat antiinflamasi kontrol positif hidrokortison. Hasil uji Friedman luka sayat dan luka bakar menunjukan nilai sigifikansi sebesar 0,000 < 0,05 yang berarti adanya perbedaan signifikansi. Berdasarkan hasil tersebut menunjukkan bahwa ekstrak daun teratai (Nymphaea pubescens L.) memiliki potensi dalam aktivitas antiinflamasi yang dapat membantu mengurangi peradangan dan penyembuhan terhadap luka. Efek antiinflamasi dari daun teratai (Nymphaea pubescens L.) diduga karena adanya senyawa aktif flavonoid dan saponin. Konsentrasi paling aktif dan efektif dalam mengatasi inflamasi adalah konsentrasi 6%. Kemudian diikuti 8%, 4%.
Utility of Immunohistochemistry in the Subtyping of Lung Carcinoma on Small Biopsies
Authors: Alam S M Mahbubul , Khaled Ahmed , Islam Saiful , Yasmin Taohida , Khurshid Narita 
Published: January 2024

Background: Hamstring tendon auto grafts in the form of quadrupled Background and objectives: In the era of precision medicine, the important task of today’s pathologist is to classify lung carcinoma into specific histologic subtypes. Thus enables the scope to identify the molecular target for targeted therapy. Hematoxylin and eosin stain alone cannot subtype lung carcinoma when particularly it exhibits solid pattern of growth. This challenge becomes more pronounced when working with small biopsy samples.
Methodology and result: A retrospective cross-sectional study was conducted to evaluate small biopsies obtained by image guided lung core or bronchoscopy over three years, from 2020-2022. Tumour morphology was evaluated, and immunohistochemistry was performed in 132 cases of lung carcinoma. In this study a small panel of three markers (TTF-1, p63 and synaptophysin) was applied as an initial approach to classify different subtypes of lung carcinoma. Additional markers (such as NapsinA, p40, CK5/6, CD56, INSM1, CK7, CK20, etc.) were incorporated based on factors like morphological characteristics, clinical information, imaging data, and the results of the initial marker panel. The largest group observed in this study comprised 67% of adenocarcinomas that showed positivity for either TTF-1 or NapsinA. Squamous cell carcinomas, identified either through p63 expression or other markers such as p40/CK5/6, accounted for 26% of cases. Additionally, 10% of cases demonstrated reactivity to neuroendocrine markers, indicating the presence of neuroendocrine tumors. Notably, immunohistochemistry successfully identified the metastatic site for 10 adenocarcinomas that were negative for both TTF-1 and NapsinA.
Conclusion: A small panel of immunomarkers can classify the lung cancer reliably and increases the confidence at all level of lung cancer management.
Pulse Vol.15, 2023 P: 16-21
Ongoing Challenges of Extubation of COVID-Pneumonic Patient in Multi-Organ Failure: a Case Report
Authors: Aziz Md Zulfiker Riad Ibn , Arif Md Masum Hossain , Mamun Abdullah Al , Noor A K M Abdun , Jakaria A K M , Chowdhury Mahfuz Ahmed , Hudaibi Khondoker Hasan Al , Noor Md Mahbub , Islam Md Sadiqul 
Published: January 2024

In this report, a case of a patient with COVID-19 pneumonia is presented who developed multi-organ failure and required mechanical ventilation. Despite multiple attempts at extubation, the patient remained intubated for an extended period due to respiratory failure. The challenges encountered during the process of extubation are discussed and the strategies employed to overcome them. This case highlights the importance of careful decision and management in patients with COVID-19 pneumonia for extubation who develop multi-organ failure.
Pulse Vol.15, 2023 P: 45-50
THE TRANSLATION OF POETRY:AN EXAMPLE FROM NAZIK AL-MALA'IKA
Authors: Asfour Mohammad 
Published: January 2024

Almost everybody agrees that poetry is what gets lost	in translation. Poetry	is said to be inseparable from the language in which it was originally written.	Different languages not only have different prosodic systems, they also have different sound	systems whose subtle effect is often difficult to estimate in the source language, let alone transferring that effect to the target language. A prose version of a poem in the same language	does not have the same effect, perhaps not even the same meaning (Brooks1947:192-214; de Beaugrande and Dressler, 1981:58). Moreover, literature in general, and poetry in particular, is more or less tied	to the source culture, which often makes it difficult to transfer adequately to the target culture without	some loss. Finally, the source language	may	offer,	through	historically	established	conventions, metaphoric possibilities that may not be available in the target language. This	is obviously a special problem relating to the translatability of metaplioric language in general (see, for example, Newmark 1995:32-33).

.
Distorted Love in Tayeb Salih's Season ofMigration to the North
Authors: NouhaHomad NouhaHomad 
Published: January 2024

All men dream: but not all equally. Those who dream by night in the dusty recesses of their minds wake in the day to find that it was vanity: but the dreamers of the day are dangerous men, for they may act their dream with open eyes to make it possible.
T. E. Lawrence'

In a blurb on the back of the French translation ofTayeb Salih's Season of Migration to the North Claude-Michel Cluny says that the novel is: 'Angoisse des batards nes des noces de 1'Afrique et de l'Occident, du passe avec le futur ...../ It plays out the agony of the bastard, or hybrid, who is the product of a love-hate relationship between East and West and of past and future,3 and reveals, as Octavio Paz puts it, 'that the ancient beliefs and customs are still in existence beneath the Western forms.'4 The novel explores the concept of time, a concept so singular in Sudan, due to its environm.ent a...11d distances, that control over either does not seem possible. Life moves at a pace different from that in the \X/estern \Vorld
. and problems are magnified or minimised accordingly by this distorted sense	of time.5 Moreover, not only time but history is distorted by c )l1stant flashba.c fu d fast=for vards 'p 1nctt1ated by the agonizing cry of (Mustafa) Sa'eed, totally lost to himself tom apart between East and West, South and North, Black and White.' 6
.
Psychic Occupation: Western Narrative Style in Beer in the Snooker Club and Season of Migration to the North
Authors: J. McDonald John 
Published: January 2024

This paper compares how two Arab Novels, Waguih Ghali's Beer in the Snooker Club (1964) written in English, and Tayeb Salih 's Season of Migration .to the North (1969) written in Arabic (trans. by Denys Johnson –Davies), depict Colonialism 's influence on Arab cultural identity through narrators who are Anglophiles. While the Arabic narrative and Western voice interact cohesively, the protagonists of Salih 's and Ghali's novels experience inter-cultural and internal conflicts which result in self-hatred, physical and identity displacement, political dissidence, and acts of questionable morality. Because both identify with an occupying culture they struggle to find stability, satisfaction or redemption in the excesses and "freedoms " of the West, and in the customs of their native cultures..
A deep learning knowledge distillation framework using knee MRI and arthroscopy data for meniscus tear detection
Authors: Ying Mengjie , Wang Yufan , Yang Kai , Wang Haoyuan , Liu Xudong 
Published: January 2024

Purpose: To construct a deep learning knowledge distillation framework exploring the utilization of MRI alone or combing with distilled Arthroscopy information for meniscus tear detection.Methods: A database of 199 paired knee Arthroscopy-MRI exams was used to develop a multimodal teacher network and an MRI-based student network, which used residual neural networks architectures. A knowledge distillation framework comprising the multimodal teacher network T and the monomodal student network S was proposed. We optimized the loss functions of mean squared error (MSE) and cross-entropy (CE) to enable the student network S to learn arthroscopic information from the teacher network T through our deep learning knowledge distillation framework, ultimately resulting in a distilled student network ST. A coronal proton density (PD)-weighted fat-suppressed MRI sequence was used in this study. Fivefold cross-validation was employed, and the accuracy, sensitivity, specificity, F1-score, receiver operating characteristic (ROC) curves and area under the receiver operating characteristic curve (AUC) were used to evaluate the medial and lateral meniscal tears detection performance of the models, including the undistilled student model S, the distilled student model ST and the teacher model T.Results: The AUCs of the undistilled student model S, the distilled student model ST, the teacher model T for medial meniscus (MM) tear detection and lateral meniscus (LM) tear detection are 0.773/0.672, 0.792/0.751 and 0.834/0.746, respectively. The distilled student model ST had higher AUCs than the undistilled model S. After undergoing knowledge distillation processing, the distilled student model demonstrated promising results, with accuracy (0.764/0.734), sensitivity (0.838/0.661), and F1-score (0.680/0.754) for both medial and lateral tear detection better than the undistilled one with accuracy (0.734/0.648), sensitivity (0.733/0.607), and F1-score (0.620/0.673).Conclusion: Through the knowledge distillation framework, the student model S based on MRI benefited from the multimodal teacher model T and achieved an improved meniscus tear detection performance.
Small organic molecules containing amorphous calcium phosphate: synthesis, characterization and transformation
Authors: Indurkar Abhishek , Kudale Pawan , Rjabovs Vitālijs , Heinmaa Ivo , Demir Öznur , Kirejevs Matvejs , Rubenis Kristaps , Chaturbhuj Ganesh , Turks Māris , Locs Janis 
Published: January 2024

As the primary solid phase, amorphous calcium phosphate (ACP) is a pivotal precursor in cellular biomineralization. The intrinsic interplay between ACP and Howard factor underscores the significance of understanding their association for advancing biomimetic ACP development. While organic compounds play established roles in biomineralization, this study presents the synthesis of ACP with naturally occurring organic compounds (ascorbate, glutamate, and itaconate) ubiquitously found in mitochondria and vital for bone remodeling and healing. The developed ACP with organic compounds was meticulously characterized using XRD, FTIR, and solid-state 13C and 31P NMR. The morphological analysis revealed the characteristic spherical morphology with particle size close to 20 nm of all synthesized ACP variants. Notably, the type of organic compound strongly influences true density, specific surface area, particle size, and transformation. The in vitro analysis was performed with MC3T3-E1 cells, indicating the highest cell viability with ACP_ASC (ascorbate), followed by ACP_ITA (itaconate). The lowest cell viability was observed with 10 %w/v of ACP_GLU (glutamate); however, 1 %w/v of ACP_GLU was cytocompatible. Further, the effect of small organic molecules on the transformation of ACP to low crystalline apatite (Ap) was examined in Milli-Q® water, PBS, and α-MEM.
Maturation and culture affect the metabolomic profile of oocytes and follicular cells in young and old mares
Authors: Bresnahan D. R. , Catandi G. D. , Peters S. O. , Maclellan L. J. , Broeckling C. D. , Carnevale E. M. 
Published: January 2024

Introduction: Oocytes and follicular somatic cells within the ovarian follicle are altered during maturation and after exposure to culture in vitro. In the present study, we used a nontargeted metabolomics approach to assess changes in oocytes, cumulus cells, and granulosa cells from dominant, follicular-phase follicles in young and old mares.Methods: Samples were collected at three stages associated with oocyte maturation: (1) GV, germinal vesicle stage, prior to the induction of follicle/oocyte maturation in vivo; (2) MI, metaphase I, maturing, collected 24 h after induction of maturation in vivo; and (3) MIIC, metaphase II, mature with collection 24 h after induction of maturation in vivo plus 18 h of culture in vitro. Samples were analyzed using gas and liquid chromatography coupled to mass spectrometry only when all three stages of a specific cell type were obtained from the same mare.Results and Discussion: Significant differences in metabolite abundance were most often associated with MIIC, with some of the differences appearing to be linked to the final stage of maturation and others to exposure to culture medium. While differences occurred for many metabolite groups, some of the most notable were detected for energy and lipid metabolism and amino acid abundance. The study demonstrated that metabolomics has potential to aid in optimizing culture methods and evaluating cell culture additives to support differences in COCs associated with maternal factors.
Transcatheter aortic valve implantation (from inception to standard treatment): a single-center observational study
Authors: Høydahl Martin Petter , Busund Rolf , Rösner Assami , Kjønås Didrik 
Published: January 2024

BackgroundTreatment of severe aortic stenosis with transcatheter aortic valve implantation (TAVI) was introduced in 2002. Since then, TAVI has become the primary treatment approach worldwide for advanced-age patients and younger patients with severe comorbidities. We aimed to evaluate the changes in patient demographics, complications, and mortality rates within 13 years.MethodsThis retrospective observational study included 867 patients who underwent TAVI at the University Hospital of North Norway in Tromsø from 2008 to 2021. The 13-year period was divided into period 1 (2008–2012), period 2 (2013–2017), and period 3 (2018–2021). The primary objective was to evaluate the changes in periprocedural (30 days), early (30–365 days), and late mortality rates (&gt;365 days) between the periods. The secondary objective was to evaluate late mortality rates by sex and age groups: &lt;70 years, 70–79 years, 80–89 years, and ≥90 years.ResultsThe periprocedural mortality rates for periods 1, 2, and 3 were 10.3%, 2.9%, and 1.2%, respectively (P &lt; 0.001). The early mortality rates were 5.6%, 5.8%, and 6.5%, respectively. No significant differences were observed in late mortality by sex or age group (&lt;70, 70–79, and 80–89 years) with a median survival of 5.3–5.6 years. The median survival in patients aged ≥90 years was 4.0 years (P = 0.018).ConclusionOur findings indicate that most patients are octogenarians, and the burden of their comorbidities should be highly considered compared to their age when evaluating the procedural outcomes. As the incidence of most complications related to TAVI has decreased, the rates of permanent pacemaker implantation remain high. Important advancements in diagnostics, valve technology, and procedural techniques have improved the periprocedural mortality rates; however, early mortality remains unchanged and poses a clinical challenge that needs to be addressed in the future.
Gut microbiota and metabolic profiles in chronic intermittent hypoxia-induced rats: disease-associated dysbiosis and metabolic disturbances
Authors: Li Cong , Shi Song 
Published: January 2024

AimChronic intermittent hypoxia (CIH) is a key characteristic of obstructive sleep apnea (OSA) syndrome, a chronic respiratory disorder. The mechanisms of CIH-induced metabolic disturbance and histopathological damage remain unclear.MethodsCIH-induced rats underwent daily 8-h CIH, characterized by oxygen levels decreasing from 21% to 8.5% over 4 min, remaining for 2 min, and quickly returning to 21% for 1 min. The control rats received a continuous 21% oxygen supply. The levels of hypersensitive C reactive protein (h-CRP), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), interleukin 8 (IL-8), and nuclear factor kappa-B (NF-κB) were measured by ELISA. Histological analysis of the soft palates was conducted using HE staining. The microbial profiling of fecal samples was carried out by Accu16STM assay. Untargeted metabolomics of serum and soft palate tissue samples were analyzed by UPLC-MS. The protein expression of cAMP-related pathways in the soft palate was determined by Western blot.ResultsAfter 28 h of CIH induction, a significant increase in pro-inflammatory cytokines was observed in the serum, along with mucosal layer thickening and soft palate tissue hypertrophy. CIH induction altered the diversity and composition of fecal microbiota, specifically reducing beneficial bacteria while increasing harmful bacteria/opportunistic pathogens. Notably, CIH induction led to a significant enrichment of genera such as Dorea, Oscillibacter, Enteractinococcus, Paenibacillus, Globicatella, and Flaviflexus genera. Meanwhile, Additionally, CIH induction had a notable impact on 108 serum marker metabolites. These marker metabolites, primarily involving amino acids, organic acids, and a limited number of flavonoids or sterols, were associated with protein transport, digestion and absorption, amino acid synthesis and metabolism, as well as cancer development. Furthermore, these differential serum metabolites significantly affected 175 differential metabolites in soft palate tissue, mainly related to cancer development, signaling pathways, amino acid metabolism, nucleotide precursor or intermediate metabolism, respiratory processes, and disease. Importantly, CIH induction could significantly affect the expression of the cAMP pathway in soft palate tissue.ConclusionsOur findings suggest that targeting differential metabolites in serum and soft palate tissue may represent a new approach to clinical intervention and treatment of OSA simulated by the CIH.
Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome
Authors: Xu Zhixiao , Lei Xiong , Chu Weiwei , Weng Luoqi , Chen Chengshui , Ye Ran 
Published: January 2024

BackgroundThe oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. The emergence of metabolic syndrome (MetS) is intricately linked to oxidative stress. Nonetheless, the correlation between OBS and MetS displays variability within distinct cohorts.ObjectiveWe worked on the relationships between OBS and the risk of MetS, MetS severity, and all-cause mortality of MetS patients.MethodsA total of 11,171 adult participants were collected from the U.S. National Health Examination Survey (NHANES) 2007-2018. Employing survey-weighted logistic models, we evaluated the relationship between OBS and MetS risk. Furthermore, survey-weighted linear models were utilized to investigate the connection between OBS and MetS severity. Among the participants, 3,621 individuals had their survival status recorded, allowing us to employ Cox proportional hazards regression models in order to ascertain the association between OBS and the all-cause mortality within the subset of individuals with MetS. The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors.ResultsAfter multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. The adjusted OR was 0.42 (95% CI 0.33-0.53) for MetS risk in the fourth OBS quartile compared with those in the first OBS quartile (P for trend &lt; 0.001). A one-unit increase in OBS was linked to a 3% reduction in MetS severity score by 3% (mean difference, -0.03; 95% CI, -0.04 to -0.03). Moreover, increased OBS correlated with decreased hazard of all-cause mortality risk among MetS subjects (adjusted hazard ratio, 0.95; 95% CI, 0.93-0.98). These associations retained their strength even subsequent to the introduction of sensitivity analyses. There existed a statistically significant negative correlation between diet/lifestyle OBS and both MetS risk as well as MetS severity.ConclusionsAn inverse correlation was observed between OBS and the susceptibility to MetS, MetS severity, and all-cause mortality of MetS patients. Health outcomes for MetS patients were positively related to antioxidant diets and lifestyles.