bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trimetazidine Attenuates Ischemia/Reperfusion-Induced Myocardial Ferroptosis by Modulating the Sirt3/Nrf2-GSH System and Reducing Mitochondrial Oxidative Stress
Authors: Tan Mingyue , Yin Yunfei , Chen Weixiang , Jin Yifeng , Zhang Jun , Zhang Yue , Zhang Lei , Jiang Tingbo , Jiang Bin , Li Hongxia 
Published: October 2023

Abstract
Background and Purpose：
Ferroptosis is a newly defined mode of cellular demise. Increasing investigatieon supports the hypothesis that ferroptosis is a crucial factor in the complex mechanisms of myocardial ischemia-reperfusion(I/R) injury. Hence, the pursuit of ferroptosis as a therapeutic approach has promise in the management of myocardial damage. Although evidence suggests that trimetazidine (TMZ) is potentially efficacious against myocardial injury, the exact mechanism of this efficacy is yet to be fully elucidated. The objective of this work is to determine whether TMZ can act as a ferroptosis resistor and affect I/R-mediated myocardial injury.
Methods：
We constructed in vitro and in vivo models of I/R using H9C2 cardiomyocytes, primary cardiomyocytes, and SD rats. The optimal concentration of TMZ was determined by CCK8 and LDH experiments. Ferroptosis was confirmed by detecting the levels of GSH, lipid peroxidation ,and Fe2+, and the morphological alterations of mitochondria under transmission electron microscopy. Western blotting, RT-qPCR, and immunofluorescence staining were performed to detect the expression of iron death-related markers, including GPX4, SLC7A11, ACSL4, TFRC, and FTH. The Sirt3/Nrf2 pathway, which is associated with ferroptosis, was detected by Western blotting. We investigated the effects of Sirt3 molecules on TMZ-mediated inhibition of ferroptosis and cardioprotection by interfering with Sirt3 expression or activity using si-Sirt3 or 3-TYP (inhibitor of Sirt3 activity).
Results:
I/R mediated the onset of myocardial ferroptosis in vitro and in vivo, as reflected by excessive iron aggregation, GSH depletion, and the increase in lipid peroxidation. TMZ largely reversed this alteration and attenuated myocardium injury. Mechanistically, TMZ upregulated the expression of Sirt3. The use of si-Sirt3 and 3-TYP partly mitigated the inhibitory effect of TMZ on I/R-mediated ferroptosis and upregulated the expression of Nrf2 and its downstream target, GPX4-SLC7A11.
Conclusions:
TMZ attenuates I/R-mediated ferroptosis by activating the Sirt3-Nrf2/GPX4/SLC7A11 signaling pathway.
Detailed studies of 12C structure and reactions
Authors: Fortunato Lorenzo 
Published: October 2023

Abstract
We are reporting here on a series of theoretical investigations with both algebraic models and geometric cluster models of 2+ state with the purpose, in particular, of establishing if the rotational bands are compatible with rigid structures or rather if they are quantum mixture of different configurations.In a first series of paper [1, 2], we assume a rigid equilateral triangle shape and study in detail several properties that descend from the algebraic framework, such as the energy spectrum, electromagnetic observables and calculate the transition densities in order to extract elastic and inelastic cross-sections for various processes.In a second series of papers [3, 4], with correlated Gaussian basis functions. The two-body density distributions indicate that the main configurations of both the 0+2 and 2+2 states are acute iscosceles triangle shapes coming from 8Be(0+)+α configurations and find some hints that the second 2+ state is not an ideal rigid rotational band member of the Hoyle state band.
Comparative Analysis of Urban Greening Design Scenarios on Microclimate and Thermal Comfort
Authors: Teshnehdel Saeid 
Published: October 2023

Abstract

According to population growth, urban sprawl, as well as global warming, attention to the impact of design on thermal comfort in open spaces is important. Thus, it is essential to climate studies and understanding environmental features, as well as results usage in improving designs. The aim of this research is to use optimal climate knowledge to improve the quality of urban spaces; so with suitable use of natural resources can be achieved in a sustainable urban environment and responsive to the needs of human. With regard to the simulation and analysis by ENVI-met software, the result of this paper showed that, by choosing the suitable species and number of trees on outdoor, Ta and the MRT in the summer were reduced by 0.29 ˚C and 20.04 ˚C respectively and the RH increased by 3.51%. Overall, PET improved from 34.92 to 26.16 ˚C and PMV decreased from 2.31 to 0.86 in the summer which means that they are reached around comfort zones.
Bronchoalveolar Lavage Fluid Cytology of Deployed Military Personnel with Chronic Respiratory Symptoms from the STAMPEDE III Study
Authors: Boster Joshua , Moore William , Anderson Jess , Gonzales Michael , Houle Mateo , Walter Robert , Morris Michael 
Published: October 2023

Abstract
Background:Deployed military personnel may be at risk for developing acute and chronic lung disease. Prior studies of this patient population have revealed that unexplained exertional dyspnea is the most common diagnosis despite an extensive evaluation. There is concern that an occult disorder may be affecting this population. This study evaluated the role for bronchoalveolar lavage (BAL) fluid analysis in the evaluation of chronic deployment associated dyspnea.
Methods: Military personnel who reported chronic respiratory symptoms were evaluated as part of the STAMPEDE III study. Participants underwent bronchoscopy with BAL as part of a standardized evaluation.
Results: 308 patients with a mean age of 38 ± 8.6 years underwent bronchoscopy with BAL. BAL cell count percentages of macrophages, lymphocytes, neutrophils, and eosinophils respectively were: 76.2 ± 17.0%, 16.3 ± 13.4%, 6.6 ± 8.9%, and 0.9 ± 3.2%. There was no clear differentiation between groups based on increases in lymphocyte counts (p = 0.640) although lymphocyte values were more elevated (21.4 ± 12.1%) in the interstitial lung disease category. Neutrophil counts (6.6 ± 8.9%) were elevated compared to the reported normal reference values and were increased in the isolated pulmonary function test (PFT) abnormality (9.4 ± 11.6%), large airway disorder (10.0 ± 7.5%), miscellaneous (10.9 ± 20.2%), and obstructive lung disease (11.0 ± 15.6%) groups. Eosinophil counts were within normal limits (0.9 ± 3.2%) and showed no differences between groups (p = 0.545); asthma patients trended higher (1.6 ± 5.7%). BAL counts for the exertional dyspnea group were within normal reference values and showed no differences from the entire cohort.
Conclusion:The addition of BAL cytology did not help differentiate those patients with unexplained dyspnea from other etiologies.
Transfer Entropy and Granger Causality in Real-world Telecommunication Networks
Authors: Polaganga Roopesh Kumar , Liang Qilian 
Published: October 2023

Abstract
Telecommunication networks are highly intricate, with numerous interacting components influenced by various known and unknown factors. Among these, Radio Access Networks (RANs) play a critical role in wireless communication. Unraveling causal relationships within such complex systems is essential for their improvement and optimization through statistical and data analysis techniques. This study pioneers the application of Transfer Entropy (TE) and Granger Causality (GC) to real-world telecommunication networks, marking the first exploration of these methods in this context. We assess their effectiveness in identifying relationships among key network attributes, offering insights for potential system optimization in practical scenarios. Furthermore, our research extends to a comparative analysis of TE and GC under varying network load conditions, utilizing live data collected from multiple base stations to uncover common patterns across identified network attributes.
The association between dietary patterns and metabolic syndrome among Iranian adults, a cross-sectional population-based study (findings from Bandare-Kong Non-Communicable Disease Cohort Study)
Authors: Kheirandish Masoumeh , Dastsouz Farideh , Azarbad Abnoos , Mohsenpour Mohammad Ali , Javedan Gholamali , Razmpour Farkhondeh , Davoodi Seyed Hossein , Ramezani-Jolfaie Nahid , Mohammadi Mohammad 
Published: October 2023

Abstract

Background
Metabolic syndrome is a cluster of metabolic disorders increasing the risk of cardiovascular disease and diabetes. Dietary patterns are supposed to be important and controllable factors in developing metabolic syndrome. The purpose of this study was to investigate the association of dietary patterns with metabolic syndrome and its components.
Subjects/Methods:
Cross-sectional data were extracted from the Bandare-Kong cohort study conducted in people aged 35 to 70. Dietary patterns were extracted using principal component analysis based on thirty-eight pre-defined food groups. Multivariable logistic regression was conducted to investigate the association between metabolic syndrome and its components with quintiles of dietary patterns in crude and adjusted models.
Results
Three major dietary patterns were identified (healthy, western, and traditional). After adjusting for covariates, the chance of metabolic syndrome was significantly decreased by 46% in the highest quintile of the healthy pattern compared to the lowest quintile. However, in fully adjusted models, no significant association between western and traditional dietary patterns was observed with the chance of metabolic syndrome. On the other hand, the fully adjusted model showed an inverse association between higher adherence to healthy dietary patterns and the chance of increased blood glucose, high waist circumference, and elevated blood pressure. The odds of abnormal levels of metabolic syndrome components were not significantly different in quintiles of the western and traditional dietary patterns.
Conclusions
Following a healthy dietary pattern, including fruits, vegetables, nuts, low-fat dairy products, and legumes, can help prevent and control metabolic syndrome.
The effect of Norethisterone Acetate (NETA) on the uterus of albino rats: Histological, histochemical, immunohistochemical and ultrastructure Study
Authors: Abd-Elkareem Mahmoud , Alnasser Sulaiman Mohammed , Meshal Alotaibi , Abdullah Raghda Ismail , Ali Ahmed U. 
Published: October 2023

Abstract
Norethisterone acetate (NETA), also known as norethindrone acetate is a progestogens medication that is widely used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders as abnormal uterine bleeding and endometriosis. There is a lack of detailed histological information regarding the effects of NETA on the uterine structure. So, the present study focuses on the uterine histological, histochemical and ultrastructure sequelae following the exposure to NETA in the albino rats. To do this aim, fourteen adult female albino rats were used. They were randomly divided into two equally groups: Control group and NETA treated group. Albino rats of control group were administered daily food, water and orally distilled water only, while rats of NETA treated group were administered daily orally 20 µg of NETA dissolved in 2 ml distilled water, food, and water. The experiment was continued for three weeks. The findings of the present work indicated that the use of NETA has negative effects on the endometrial epithelium (proliferation, autophagy and apoptosis), glands (necrotic, apoptotic or pseudosecretory glands) and stromal and myometrial reactions (granulocytes, connective tissue remodeling, apoptosis, myocytes hypertrophy). This work revealed that NETA has desynchronized progestogenic effect on the uterine tissues of the albino rat and thereby prevent implantation and pregnancy.
Precision reduction of femoral neck fractures: A novel strategy based on the femoral neck fracture morphology
Authors: Lin Dongze , Peisheng Chen , Chaohui Lin , Lin Fengfei 
Published: October 2023

Abstract

Background
In femoral neck fractures the secondary damage caused by repeated multiple reductions needs to be prevented. Accordingly, the aim of this study was to achieve an anatomical reduction in the first manipulation of reduction in femoral neck fractures. We propose a new reduction strategy using the x-ray morphology of femoral neck fractures for preoperative planning. In the present study we compared this approach to conventional operation procedures for the treatment of femoral neck fractures.
Method
From 2020 to 2021, 35 patients with femoral neck fractures were operated with this reduction strategy. Those were compared with 34 patients treated without the proposed preoperative method. All patients were compared for consistency between the preoperative assessment and the intraoperative execution of the reduction approach, number of reductions, operative time, number of fluoroscopies, intraoperative bleeding, and reduction quality.
Results
The operative time of patients in the study group was significantly shorter (38.40±10.26 min) than that of the control group (47.26±9.09 min), and the number of reductions [1.0 (1.0,1.0)] was significantly less than that of the control group [2.0 (1.75,2.25)]. The number of fluoroscopies (10.27±2.84) was also significantly less than that of the control group (13.53±2.59) times. The KAPPA value = 0.886 shows the good agreement between the preoperative proposed protocol and the intraoperative protocol about the study group .The bleeding, quality of repositioning, Harris Hip score, MOS 12-item Short Form Survey (SF-12), and early complication rate were not statistically different between the groups (P > 0.05).
Conclusion
The selection of the appropriate repositioning method based on the analysis of femoral neck fracture X-ray morphology can improve the efficiency and accuracy of preoperative planning. This reduces the secondary damage that may be caused by multiple reduction, shortens the operation time and reduces the exposure to radiation.
An overall study on flavor characterization of Citrus Puerh tea based on GC-MS-O and untargeted metabolomics
Authors: Sun Jiaqing , Cai Weitong , Feng Tao , Chen Da , Lu Jun , Song Shiqing , Yao Lingyun , Sun Min , Wang Huatian , Liu Qian , Yu Chuang 
Published: October 2023

Abstract
Chinese Citrus Pu-erh tea is recognized for its unique flavor, which is composed of key aroma-active compounds and affected by taste-impact metabolites. In this study, the whole citrus Pu-erh tea (CP), its out-layer fruit (OF) container and inside tea (IT) powder, were analyzed by solvent-assisted flavor evaporation (SAFE) coupled with GC-MS-O and UHPLC-MS/MS. As the result, 47 important volatiles were identified, including 27 (IT), 30 (OF) and 27 (CP) volatiles that were screened out based on their OAV (odor activity value) and ACI (aroma character impact value), and further validated by aroma omission/recombination experiment. Combined with the sensory evaluation and PLSR model, the aroma profile of CP was characterized with the following ten flavor attributes: sweet (vanillin); floral (β-ionone); fruity (methyl anthranilate, methyl methanthranilate, citronellal); roasted (thymol); musty (p-cymene), woody (perillaldehyde); herbal (linalool, α-terpineol); phenolic (2,4-di-tert-butylphenol, p-cresol); minty (dihydrocarvone); and fatty (octanoic acid) volatiles. As for the non-volatile taste-impact chemicals, the most prominent metabolites were identified as flavonoids that mainly contributed to the taste of bitter (catechin, epicatechin, gallocatechin), astringency (leucopelargonidin) and sweet (neohesperidin). This novel finding has provided an insight and better understanding of the flavor profile of Citrus Pu-erh tea and some guidance for flavor pairing and taste improvement.
Effect of 40hz Light Flicker on Cognitive Impairment and Transcriptome of Hippocampus in Right Unilateral Common Carotid Artery Occlusion Mice
Authors: Niu Zhaorui , Yu Minjie , Xu Peixia , Liu Renchuan , Li Shangda , Wu Congchong , Huang Bochao , Ye Xinyi , Hu Jianbo , Xu Yi , Lu Shaojia 
Published: October 2023

Abstract
Vascular cognitive impairment caused by chronic cerebral hypoperfusion (CCH) seriously affects the living quality in elderly patients. However, there has been no effective treatment to control this disease. This study investigated the potential neuroprotective effect of the 40hz light flicker in a mouse model of CCH. CCH was induced in male C57 mice by right unilateral common carotid artery occlusion (rUCCAO), leading to chronic brain injury. The mice underwent 40hz light flicker stimulation for 30 days after surgery. The results showed that 40hz light flicker treatment ameliorated the memory deficits after rUCCAO and alleviated the damage to neurons in the frontal lobe and hippocampus. Light flicker administration at 40hz decreased IL-1β and TNF-α levels in the frontal lobe and hippocampus, although immunohistochemistry found that it did not exert angiogenesis in mice with rUCCAO. Gene expression profiling revealed that the induction of genes was mainly enriched in inflammatory-related pathways. Our findings demonstrate that 40hz light flicker can suppress cognitive impairment caused by rUCCAO and that this effect is may be invovled in the attenuation of neuroinflammation.
Analysis of clinical characteristics and factors affecting treatment responses in patients with pyoderma gangrenosum: A multicenter study of 239 patients
Authors: Erduran Funda , Adışen Esra , Hayran Yıldız , Aksoy Güneş Gür , Alpsoy Erkan , Selçuk Leyla Baykal , Doğan Sibel , Yazıcı Ayça Cordan , Öktem Ayşe , Güngör Malik , Afacan Elif , Kuşçu Deniz Devrim , Elmas Leyla , Aydoğan Kübra , Bayramgürler Dilek , Demirsoy Evren Odyakmaz , Akyol Melih , Yasak Rukiye , Erdoğan Hilal Kaya , Acer Ersoy , Ergun Tulin , Yaylı Savaş , Bulut Ferhan , Saraç Esra , Aktaş Akın 
Published: October 2023

Abstract
Pyoderma gangrenosum (PG) is a chronic disease characterized by recalcitrant skin ulcers. We aimed to evaluate retrospectively the demographic, clinical characteristics, treatment data and factors affecting treatment responses of patients followed up with diagnosis of PG in 12 tertiary care centers from 8 different provinces in Turkey between the years 2012–2022. We included a total of 239 patients of whom 143 (59.8%) were female and 96 (40.2%) were male, with an average age of 54.2 ± 17.4 years. At least one comorbidity associated with PG was found in 51.5% of our patients. The most common comorbidities were inflammatory arthritis (18.8%) and inflammatory bowel disease (IBD) (15.9%). The most common treatment was systemic steroids (75.7%). Among these patients 50.8% used systemic steroids as the sole systemic agent, while 49.2% used at least one adjuvant immunosuppressive agent. The general characteristics of our patients who responded well to systemic steroid treatment were those with a late onset of disease, shorter disease duration, fewer lesions, single region involvement, negative wound culture results, negative pathergy, and those without inflammatory arthritis and IBD (all p < 0.05). Biological agents were used in 18.4% of our patients in our study. The general characteristics of the patients who switched to biologics as a second or third line treatment are those with early disease onset, younger patients, males, those with autoinflammatory diseases, those with IBD and hidradenitis suppurativa and pathergy positive ones (all p < 0.05). Our study had compelling data concerning two specific patient groups: Pathergy positivite and early onset (onset age < 30) PG groups. We think that investigation for accompanying autoinflammatory diseases at the time of diagnosis in these two groups is necessary and the patients in these two groups are more resistant to treatment, necessitating more complicated treatments. We believe that the results of our multicenter study will contribute to the literature.
Bond Strength of Thermally Aged CAD/CAM Hybrid Nanoceramic Repaired with Nanohybrid Resin Composite
Authors: AbouShahba Mostafa , Younis Sara H. 
Published: October 2023

Abstract
Purpose. To assess shear bond strength (SBS) of nanohybrid resin composite used to repair CAD/CAM Hybrid Nanoceramic ceramic after various surface treatments.
Materials and Methods. SHOFU HC Hybrid Ceramic disks were sliced to obtain circular-shaped specimens (n= 30). All specimens were thermocycled (5000 thermal cycles), then divided into three groups according to surface treatment performed (sandblasting, HF acid etching, and laser irradiation) (n = 10). Repair with nanohybrid resin composite was performed. SBS values were obtained, and failure modes were determined. Data were statistically analyzed (P ≤ 0.05).
Results. The highest SBS mean value was found with (Sandblasting), while the lowest mean value was found with (Laser). There was a statistically significant difference between (Sandblasting), (Hydrofluoric acid) and (Laser) groups where (p=0.001). Statistically significant difference was found between (Sandblasting) and each of (Hydrofluoric acid) and (Laser) groups where (p=0.003) and (p=0.001) respectively, while no statistically significant difference was found between (Hydrofluoric acid) and (Laser) groups where (p=0.291).
Conclusion. Surface treatment of the CAD/CAM hybrid nanoceramic material surface with sandblasting before repairing is mandatory to enhance the bond strength with nanohybrid resin composite repairing material. HF acid etching and laser irradiation are alternative surface treatment methods for CAD/CAM hybrid nanoceramic materials.
Masked Facial Recognition System using Multi-Branch Deep Learning Models and Splatted Dataset.
Authors: Fahim Mahmoud , Abdel-Nasser Mohamed , Abdelwahab Moataz , Abdel-Rahman Adel B. 
Published: October 2023

Abstract
In the last decade, face recognition (FR) has gained more importance in applications like security, access control, …etc. The FR performance gets closer to the human performance. But the spread of Covid-19 disease returns it some steps behind. The fear of covid-19 dangerousness forced people to wear medical masks. Wearing a mask increased the difficulty by losing half of the data behind the mask. In this paper, we propose a small identification system containing two parts. The first part, the detection part, takes the image from a video frame or image, and it detects the face/s using MTCNN detection. The second part, the decision part, used the output face/s from the first part and splits the face into lower and upper partitions. The lower partition enters the masked/unmasked CNN model. The upper partition is input to identify the person CNN model. We describe three proposed models with an accuracy of 93%, 99.88%, and 100%. Our strategy for dealing with the dataset is to divide the dataset into small datasets, each containing only fifty classes at most. So that several models are trained on small datasets, and each model is trained on small datasets different from those used for training in the other model, instead of training one model on the primary dataset. This strategy helped to increase accuracy and reduce error, execution time, and training time than required to train a single model on the main dataset.