bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel aging-associated lncRNA signature for predicting prognosis in osteosarcoma
Authors: He Yi , Huang Xiao , Ma Yajie , Yang Guohui , Cui Yuqing , Lv Xuefeng , Zhao Rongling , Jin Huifang , Tong Yalin , Zhang Xinyu , Li Jitian , Peng Mengle 
Published: January 2024

AbstractOsteosarcoma (OS) is one of the most prevalent bone tumors in adolescents, and the correlation between aging and OS remains unclear. Currently, few accurate and reliable biomarkers have been determined for OS prognosis. To address this issue, we carried out a detailed bioinformatics analysis based on OS with data from the Cancer Genome Atlas data portal and Human Aging Genomic Resources database, as well as in vitro experiments. A total of 88 OS samples with gene expression profiles and corresponding clinical characteristics were obtained. Through univariate Cox regression analysis and survival analysis, 10 aging-associated survival lncRNAs (AASRs) were identified to be associated with the overall survival of OS patients. Based on the expression levels of the 10 AASRs, the OS patients were classified into two clusters (Cluster A and Cluster B). Cluster A had a worse prognosis, while Cluster B had a better prognosis. Then, 5 AASRs were ultimately included in the signature through least absolute shrinkage and selection operator-Cox regression analysis. Kaplan‒Meier survival analysis verified that the high-risk group exhibited a worse prognosis than the low-risk group. Furthermore, univariate and multivariate Cox regression analyses confirmed that the riskScore was an independent prognostic factor for OS patients. Subsequently, we discovered that the risk signature was correlated with the properties of the tumor microenvironment and immune cell infiltration. Specifically, there was a positive association between the risk model and naïve B cells, resting dendritic cells and gamma delta T cells, while it was negatively related to CD8+ T cells. Finally, in vitro experiments, we found that UNC5B-AS1 inhibited OS cells from undergoing cellular senescence and apoptosis, thereby promoting OS cells proliferation. In conclusion, we constructed and verified a 5 AASR-based signature, that exhibited excellent performance in evaluating the overall survival of OS patients. In addition, we found that UNC5B-AS1 might inhibit the senescence process, thus leading to the development and progression of OS. Our findings may provide novel insights into the treatment of OS patients.
Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults
Authors: Takano Kosuke , Monna-Oiwa Maki , Isobe Masamichi , Kato Seiko , Takahashi Satoshi , Nannya Yasuhito , Konuma Takaaki 
Published: January 2024

AbstractAlthough daily higher urinary sodium (Na) and potassium (K) excretion ratio is associated with the risk of cardiovascular disease in the general population, a low Na/K ratio is associated with renal dysfunction in critically ill patients. Thus, we retrospectively analyzed the impact of daily urinary Na and K excretion and their ratio on non-relapse mortality (NRM) and overall mortality in 172 adult single-unit cord blood transplantation (CBT) patients treated at our institution between 2007 and 2020. Multivariate analysis showed that a low urinary Na/K ratio at both 14 days (hazard ratio [HR], 4.82; 95% confidence interval [CI], 1.81–12.83; P = 0.001) and 28 days (HR, 4.47; 95% CI 1.32–15.12; P = 0.015) was significantly associated with higher NRM. Furthermore, a low urinary Na/K ratio at 28 days was significantly associated with higher overall mortality (HR, 2.38; 95% CI 1.15–4.91; P = 0.018). Patients with a low urinary Na/K ratio had decreased urine volume, more weight gain, experienced more grade III–IV acute graft-versus-host disease, and required corticosteroids by 28 days after CBT. These findings indicate that a low urinary Na/K ratio early after single-unit CBT is associated with poor NRM and survival in adults.
Mass spectra prediction with structural motif-based graph neural networks
Authors: Park Jiwon , Jo Jeonghee , Yoon Sungroh 
Published: January 2024

AbstractMass spectra, which are agglomerations of ionized fragments from targeted molecules, play a crucial role across various fields for the identification of molecular structures. A prevalent analysis method involves spectral library searches, where unknown spectra are cross-referenced with a database. The effectiveness of such search-based approaches, however, is restricted by the scope of the existing mass spectra database, underscoring the need to expand the database via mass spectra prediction. In this research, we propose the Motif-based Mass Spectrum prediction Network (MoMS-Net), a GNN-based architecture to predict the mass spectra pattern utilizing the structural motif information of the molecule. MoMS-Net considers both a molecule and its substructures as a graph form, which facilitates the incorporation of long-range dependencies while using less memory compared to the graph transformer model. We evaluated our model over various types of mass spectra and showed the validity and superiority over the conventional models.
Chaotic dynamics in X-ray free-electron lasers with an optical undulator
Authors: Abbasi E. , Jafari S. 
Published: January 2024

AbstractIn this work, the chaotic motions of relativistic electrons in X-ray free-electron lasers are investigated using an optical undulator in the presence of a magnetized ion-channel background. To miniaturize X-ray light sources, the optical undulator is a promising concept. The optical undulator provides higher optical gain than conventional magnetostatic undulators due to its micrometer wavelength. In addition, it reduces the required electron beam energy from several GeV to the multi-MeV range to produce X-ray pulses. The interaction of an optical undulator with an intense relativistic electron beam is a highly non-linear phenomenon that can lead to chaotic dynamics. At synchrotron radiation sources, the possibility of chaos control for X-ray FELs can be critical for certain classes of experimental studies. The equations of motion for a relativistic electron propagating through the optical undulator in the presence of a magnetized ion-channel can be derived from the Hamiltonian of the interaction region. Simulation results revealed that the intensity of the perturbation route from orderly behavior to chaos depends on the beam density, axial magnetic field strength, ion-channel density parameter, and pump laser undulator. Specific values of parameters were obtained for the transition from regular to chaotic paths. Bifurcation diagrams of the system were plotted to demonstrate the origin of chaos at a critical point, and Poincaré maps were created to distinguish between chaotic and orderly motions of electrons. The proposed new scheme can help to improve X-ray FELs, which have potential usages in basic sciences, medicine, and industry.
Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis
Authors: Morelos-Santana E. , Islas-Preciado D. , Alcalá-Lozano R. , González-Olvera J. , Estrada-Camarena E. 
Published: January 2024

AbstractCocaine/crack abstinence periods have higher risk of relapse. Abstinence as initial part of the recovery process is affected by learning and memory changes that could preserve the addictive cycle. To further understand how the interruption of cocaine/crack consumption affects neurotrophin level we performed the present systematic review and meta-analysis following the PRISMA statement (number CRD42019121643). The search formula was conducted in PubMed, Web of Science, Embase, ScienceDirect, and Google Scholar databases. The inclusion criterion was cocaine use disorder in 18 to 60-year-old people, measuring at least one neurotrophin in blood before and after a controlled abstinence period. Studies without pre-post design were excluded. Five investigations had nine different reports, four of them were subjected to a meta-analysis (n = 146). GRADE risk of bias method was followed. Individual studies reported increased peripheral brain derived neurotrophic factor (BDNF) after abstinence, evidence pooled by Hedge’s g showed no significant change in BDNF after abstinence. Relevant heterogeneity in the length of the abstinence period (12–32 days), last cocaine/crack consumption monitoring and blood processing were detected that could help to explain non-significant results. Further improved methods are suggested, and a potential BDNF augmentation hypothesis is proposed that, if true, would help to understand initial abstinence as a re-adaptation period influenced by neurotrophins such as the BDNF.
Assessment of refining efficiency during the refining cycle in a foundry degassing unit in industrial conditions
Authors: Socha Ladislav , Prášil Tomáš , Gryc Karel , Svizelova Jana , Saternus Mariola , Merder Tomasz , Pieprzyca Jacek , Nuska Petr 
Published: January 2024

AbstractThe article focuses on the issue of improving the efficiency of a Foundry Degassing Unit (FDU) via operational testing of aluminium alloys during casting at MOTOR JIKOV Slévárna a.s.. As part of the research, the efficiency of the refining process in the FDU was assessed. The main emphasis was placed on determining the moment of the greatest decrease in the hydrogen content in the melt and whether it is possible to shorten the refining cycle. The values of the Dichte Index were determined, on the basis of which the degassing curve was plotted and the progress of the melt degassing was assessed. To ensure the required quality of castings, the maximum allowable value of the Dichte Index ranged from 3 to 4%. During the process, the temperature drop during the refining cycle was also determined. The total temperature drop from pouring the melt into the ladle to the end of refining ranged from 26 to 32 °C, which is within the acceptable limits of the foundry. Based on the knowledge resulting from the operational experiments, recommendations were formulated to optimize the refining technology at the FDU for the MOTOR JIKOV Slévárna a.s. foundry.
Cryptographic triboelectric random number generator with gentle breezes of an entropy source
Authors: Kim Moon-Seok , Tcho Il-Woong , Choi Yang-Kyu 
Published: January 2024

AbstractA wind-driven triboelectric nanogenerator (W-TENG) is a promising energy harvesting device due to its clean, ubiquitous and unexhausted properties. In addition, a W-TENG induces unpredictable chaotic outputs from wind flow that can serve as an entropy source for cryptography. This can be applied to a true random number generator (TRNG) for a secured system due to its inherent turbulent nature; thus, a W-TENG with a two-in-one structure can simultaneously generate both power and true random numbers. However, a previously reported W-TENG had one major drawback: a wind velocity of 10 m/s is required for stable energy harvesting by wind force. Thus, it is timely to demonstrate a W-TENG-based RNG whose operating condition is below 3 m/s, which is a gentle breeze similar to natural wind. In this study, we demonstrate a wind-driven cryptographic triboelectric random number generator (WCT-RNG) by using a W-TENG whose operating condition for wind speed is below 3 m/s by adopting a rear-fixed film structure instead of a conventional structure. The rear-fixed film refers to the fluttering film being freestanding on the front-side and fixed on the rear-side, where the front- and rear-sides are the wind inlet and outlet, respectively. The WCT-RNG enables the W-TENG to operate below a 3 m/s wind velocity. Because of this, the working time of the WCT-RNG is dramatically enhanced from only 8–42% at an average altitude above sea level. As the capability of operating at low wind speeds is significantly improved, a WCT-RNG becomes more useful and practical for generating both power and true random numbers in a single device. The device can thereby lead to the construction of a self-powered TRNG and secure communication for Internet of Things (IoT) devices in various environments, even under a gentle breeze. In this study, we explain the design of a WCT-RNG structure and also evaluate its randomness by using an NIST SP 800-22 B test suite with a reliability test.
Assessment of macular choroidal and retinal thickness: a cohort study in Tibetan healthy children
Authors: Yao Yao , Fu Jing , Liu Jiawen , Li Lei , Chen Weiwei , Meng Zhaojun 
Published: January 2024

AbstractThis research investigates the distribution, progressive changes, and contributing factors of macular choroidal and retinal thickness in Tibetan children utilizing swept-source optical coherence tomography (SS-OCT). The Lhasa childhood study recruited 1632 students from seven primary schools in Lhasa. These participants underwent OCT and ophthalmological evaluations, encompassing retinal and choroidal thickness measurements, refractive error, axial length (AL), and systemic examinations. The median age of the scholars was 8.57 ± 0.50 years with a median spherical equivalent (SE) of 0.19 ± 1.28D. Multivariate regression analysis revealed that thinner macular choroid thickness was correlated with lower value of SE, worse best-corrected visual acuity, higher mean arterial blood pressure (MABP) and boys, while retinal thickness was associated with better image quality and lower value of SE. The choroid and retina were significantly thinner in myopic children. SE was positively related to the thickness of all choroidal and full retinal subregions. In comparison to baseline data from 20 months prior, most regions of the full retina had significantly thinned. Choroidal thickness of Tibetan children is thinner than that of same-age children from other regions. Thinning of retina, the outer-sector GCC and GCIPL may be specified as a follow-up and prognostic indicator for myopia.
Phase-separated stretchable conductive nanocomposite to reduce contact resistance of skin electronics
Authors: Lee Hyunjin , Kim Hye Jin , Shin Yoonsoo , Kim Dae-Hyeong 
Published: January 2024

AbstractSkin electronics, facilitating a high-quality interface between external devices and human skin for recording physiological and/or electrophysiological signals as well as delivering external electrical and/or mechanical energy into the human body, has shown significant progress. However, achieving mechanically conformal contact and electrically low contact resistance at the device-skin interface remains challenging. Here, we propose a material strategy to potentially address such an issue by using phase separation of silver nanowires and silver nanoparticles (Ag NWs and Ag NPs) within a stretchable conductive nanocomposite (NC). This phase-separated NC ensures low contact resistance and high conductivity, which are key requirements in skin electronics, while maintaining excellent mechanical contact with the skin. To achieve phase separation, we hydrophobically treated the surfaces of Ag NWs and Ag NPs. Then, as the NC solidified, the solvent contained in the NC was slowly evaporated to sufficiently precipitate Ag NPs within the NC. As a result, the phase-separated NC exhibited high conductivity (~ 18,535 S cm−1), excellent stretchability (~ 80%), and low contact resistance on both the top and bottom NC surfaces (average ~ 0.132 Ω). The phase-separated NC has enabled implementation of high performance skin-mounted devices, including strain sensors, electrophysiological sensors, and a wearable heater.
Ketosis prevents abdominal aortic aneurysm rupture through C–C chemokine receptor type 2 downregulation and enhanced extracellular matrix balance
Authors: Sastriques-Dunlop Sergio , Elizondo-Benedetto Santiago , Arif Batool , Meade Rodrigo , Zaghloul Mohamed S. , Luehmann Hannah , Heo Gyu S. , English Sean J. , Liu Yongjian , Zayed Mohamed A. 
Published: January 2024

AbstractAbdominal aortic aneurysms (AAAs) are prevalent with aging, and AAA rupture is associated with increased mortality. There is currently no effective medical therapy to prevent AAA rupture. The monocyte chemoattractant protein (MCP-1)/C–C chemokine receptor type 2 (CCR2) axis critically regulates AAA inflammation, matrix-metalloproteinase (MMP) production, and extracellular matrix (ECM) stability. We therefore hypothesized that a diet intervention that can modulate CCR2 axis may therapeutically impact AAA risk of rupture. Since ketone bodies (KBs) can trigger repair mechanisms in response to inflammation, we evaluated whether systemic ketosis in vivo could reduce CCR2 and AAA progression. Male Sprague–Dawley rats underwent surgical AAA formation using porcine pancreatic elastase and received daily β-aminopropionitrile to promote AAA rupture. Rats with AAAs received either a standard diet, ketogenic diet (KD), or exogenous KBs (EKB). Rats receiving KD and EKB reached a state of ketosis and had significant reduction in AAA expansion and incidence of rupture. Ketosis also led to significantly reduced aortic CCR2 content, improved MMP balance, and reduced ECM degradation. Consistent with these findings, we also observed that Ccr2−/− mice have significantly reduced AAA expansion and rupture. In summary, this study demonstrates that CCR2 is essential for AAA expansion, and that its modulation with ketosis can reduce AAA pathology. This provides an impetus for future clinical studies that will evaluate the impact of ketosis on human AAA disease.
Risk factors and prevalence of hypertension in older adults from south-eastern Poland: an observational study
Authors: Leszczak Justyna , Czenczek-Lewandowska Ewelina , Asif Muhammad , Baran Joanna , Mazur Artur , Wyszyńska Justyna 
Published: January 2024

AbstractThe aim of this study was to assess the prevalence of hypertension and to investigate risk factors linked to hypertension in older adults. An observational study was conducted in a group of adults between 60 and 85 years of age, living in south-eastern Poland. In line with the specific inclusion criteria, 80 women and 29 men were enrolled for the study (109 adults). Participants’ body weight, height, and body fat percentage (BFP) were assessed using a bioelectrical impedance analysis, blood pressure was measured using automated oscillometric sphygmomanometer, moderate-to-vigorous physical activity (MVPA) and sedentary time were assessed using a tri-axial accelerometer, whereas data related to socio-economic and lifestyle factors were collected using a self-report technique. Arterial hypertension was found at a rate of 16% in participants with normal body weight, 22% in those with overweight and 85% in those with obesity. Body mass index (BMI) and BFP correlated significantly with systolic blood pressure (SBP) and diastolic blood pressure (DBP). The highest median SBP and DBP values were found in the group of participants with obesity, and the lowest values were identified in those with normal body weight. Out of all the investigated socio-economic risk factors linked to hypertension, education level was the only one that showed significant associations. A logistic regression analysis was performed to check which factors were most strongly associated with hypertension in the study group. The stepwise method showed that hypertension was more common in participants with a higher BMI, and BFP and in those who did not meet MVPA recommendation.
Retention rate of subcutaneous TNF inhibitors in axial spondyloarthritis in a multicentre study from the RIC-FRANCE network
Authors: Larid Guillaume , Baudens Guy , Tiemdjo-Djimaffo Georges , Coquerelle Pascal , Goeb Vincent , Guyot Marie Hélène , Marguerie Laurent , Maury Frédéric , Veillard Eric , Houvenagel Eric , Salmon Jean-Hugues , Flipo René-Marc , Gervais Elisabeth 
Published: January 2024

AbstractThe objectives of our study were to assess retention rate, safety, and predictive factors for retention of subcutaneous (SC) TNF inhibitors (TNFi) (adalimumab (ADA), etanercept (ETN), golimumab (GOL), and certolizumab pegol (CZP)) in axial spondyloarthritis (axSpA) depending on the line of treatment in real-life conditions. A multicentre retrospective observational study was conducted including 552 patients fulfilling the ASAS criteria for axSpA followed in the RIC-France register who began SC-TNFi between 01/01/13 and 08/31/2018 for a total of 824 prescriptions. Taking all lines of treatment into account, GOL had a significantly higher retention rate compared with ADA, ETN, and CZP with a mean retention length of 59 months. As first-line bDMARDs, GOL had a significantly higher retention rate compared with ADA and ETN. ETN had the best retention rate when prescribed as at least 3rd bDMARD. Taking all lines of treatment into account, female sex, peripheral disease, BASDAI at initiation, and line of treatment were predictive factors for treatment cessation. Primary inefficiency was the most frequent reason for treatment cessation. In conclusion, GOL showed the highest retention rate in axSpA. Male sex, absence of peripheral disease, and early line of prescription were associated with better SC-TNFi retention in axSpA.
Calcitonin gene-related peptide regulates periodontal tissue regeneration
Authors: Miki Koji , Takeshita Noboru , Yamashita Motozo , Kitamura Masahiro , Murakami Shinya 
Published: January 2024

AbstractCalcitonin gene-related peptide (CGRP), a neuropeptide composed of 37 amino acids secreted from the sensory nerve endings, reportedly possesses various physiological effects, such as vasodilation and neurotransmission. Recently, there have been increasing reports of the involvement of CGRP in bone metabolism; however, its specific role in the pathogenesis of periodontitis, particularly in the repair and healing processes, remains to be elucidated. Therefore, this study aimed to investigate dynamic expression patterns of CGRP during the destruction and regeneration processes of periodontal tissues in a mouse model of experimental periodontitis. We also explored the effects of CGRP on periodontal ligament cells, which can differentiate to hard tissue-forming cells (cementoblasts or osteoblasts). Our findings demonstrated that CGRP stimulation promotes the differentiation of periodontal ligament cells into hard tissue-forming cells. Experimental results using a ligature-induced periodontitis mouse model also suggested fluctuations in CGRP expression during periodontal tissue healing, underscoring the vital role of CGRP signaling in alveolar bone recovery. The study results highlight the important role of nerves in the periodontal ligament not only in sensory reception in the periphery, as previously known, but also in periodontal tissue homeostasis and tissue repair processes.