bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five-year outcomes with gefitinib induction and chemoradiotherapy in EGFR-mutant stage III non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study
Authors: Hotta Katsuyuki , Saeki Sho , Sakata Shinya , Yamaguchi Masafumi , Harada Daijiro , Bessho Akihiro , Tanaka Kentaro , Inoue Koji , Inoue Koji , Gemba Kenichi , Kubo Toshio , Sato Akiko , Ichihara Eiki , Watanabe Hiromi , Kishimoto Junji , Shioyama Yoshiyuki , Katsui Kuniaki , Sugio Kenji , Kiura Katsuyuki 
Published: February 2025

Abstract

Background
We previously showed the 2-year OS rate, the primary endpoint, of 90% in a phase II trial of gefitinib induction followed by chemoradiotherapy (CRT) in unresectable, stage III, EGFR-mutant, non-small-cell lung cancer (NSCLC). However, neither long-term survival data nor late-phase adverse event profiles have been presented.

Patients and methods
Patients with unresectable, EGFR-mutant, stage III NSCLC were administered gefitinib monotherapy for 8 weeks. After confirming no disease progression during induction therapy, cisplatin and docetaxel on days 1, 8, 29, and 36 with concurrent radiotherapy at a total dose of 60 Gy were subsequently administered.

Results
In the enrolled twenty patients, the 5-year OS rate and median survival time were 70.0% [95% confidence interval: 45.1–85.3] and 5.5 years [4.91-NE], respectively, whereas 5-year PFS rate and median PFS time were 15.0% (3.7–33.5) and 1.4 years [0.69–2.29], respectively. Efficacy did not seem influenced even if radiation field was re-planed in response to the effect of gefitinib induction. As for late adverse events, pulmonary fibrosis occurred in 7 patients (35%). The median time from completion of CRT to the occurrence of the event was 245 days. All were grade 1, and there was no evidence of cavitation of the lesions or chronic infections such as Aspergillus infection during the course of the disease. One case of small cell lung cancer occurred during the period.

Conclusions
With longer follow-up time, we demonstrated favorable efficacy with tolerable toxicity profiles in the EGFR-TKI induction followed by standard CRT in EGFR-mutant, stage III, NSCLC.

Trial registration numbers
UMIN00005086. https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000006047&type=summary&language=EjRCTs071180036. https://jrct.niph.go.jp/latest-detail/jRCTs071180036
Genetic structure of invasive ctenophore Mnemiopsis leidyi populations in temperate northern European waters is consistent with a southern North Sea overwintering refuge
Authors: Lüskow Florian , Knudsen Steen Wilhelm 
Published: February 2025

Abstract
The ctenophore Mnemiopsis leidyi is native to the Atlantic coasts of the Americas and is considered a threat to biodiversity and food webs in recipient ecosystems. Most of these invasive ctenophores perish during the cold winter in temperate northern European waters (North and Baltic Seas) but spread again every summer/autumn. We collected ctenophores from the southern North Sea, inner Danish waters, and western Baltic Sea in 2017 and 2018, and sequenced genomic DNA obtained from tissue samples. We obtained sequences of internal transcribed spacer (ITS) 1 and 2, and the intervening 5.8S fragment and partial fragments of the flanking 18S rRNA and 28S rRNA genes from nuclear DNA. Excluding the rRNA regions and focussing on only the two ITS sequences, we compared with ITS sequences archived in databases from specimens in its native (Northwest Atlantic) and other invaded habitats (Caspian Sea, Mediterranean Sea, central-western Atlantic Ocean). The comparison revealed no significant difference in genetic variation among temperate northern European sampling locations but showed variation when compared with native and other invaded habitats. No significant genetic difference was identified between specimens collected in the temperate northern European waters for two consecutive years. The very low interregional and interannual genetic variations in M. leidyi specimens in the Northeast Atlantic are consistent with the presence of one single panmictic population in northern European waters and with the hypothesis, also suggested in previous studies, that annual dispersal from the southeastern North Sea into the western Baltic Sea can be traced back to the same population, which most likely originates every spring from the Dutch Wadden Sea and the English Channel.
Herbal remedies for oral and dental health: a comprehensive review of their multifaceted mechanisms including antimicrobial, anti-inflammatory, and antioxidant pathways
Authors: Anwar Mohamed A. , Sayed Ghadir A. , Hal Dina M. , Hafeez Mohamed S. Abd El , Shatat Abdel-Aziz S. , Salman Aya , Eisa Nehal M. , Ramadan Asmaa , El-Shiekh Riham A. , Hatem Shymaa , Aly Shaza H. 
Published: February 2025

Abstract
Across diverse cultures, herbal remedies have been used to alleviate oral discomfort and maintain dental hygiene. This review presents studies on herbal remedies with remarkable antimicrobial, anti-inflammatory, antioxidant, anticancer, anticaries, analgesic, and healing properties. The manuscripts demonstrate the depth of scientific inquiry into herbal remedies used for the management of various oral and dental health conditions. These include gingivitis, oral ulcers, mucositis, periodontitis, oral pathogens, carcinoma, xerostomia, and dental caries. Researchers have investigated the phytochemical and pharmacological properties of plant-derived compounds and their extracts evaluated their interactions with oral pathogens and inflammatory processes. The convergence of traditional knowledge and rigorous scientific investigation offers a compelling narrative, fostering a deeper understanding of herbal remedies as viable alternatives to conventional dental interventions. This work has the potential to provide patients with access to gentle, yet effective solutions, and simultaneously offer dental health professionals the opportunity to enrich their knowledge, and ability to provide personalized, holistic care. This review highlights the symbiotic relationship between herbal medicine and scientific understanding, emphasizing the importance of disseminating this knowledge to benefit both practitioners and patients, enabling evidence-based decision-making in dental care. The exploration of herbal remedies offers a promising alternative, potentially mitigating some of these side effects while promoting oral health in a more natural and holistic manner.
Benefits of the Use of Monte Carlo Simulations in Cryogenic Detector Design
Authors: Lotti Simone , D’Andrea Matteo , Macculi Claudio , Piro Luigi , Kilbourne Caroline , McCammon Dan , Kraft Ralph 
Published: February 2025

Abstract
Monte Carlo simulations represent a useful tool to predict and understand the behavior of X-ray detectors in space and on ground. We made use of the Geant4 software to simulate the performances of several TES detectors. We investigated the performances of the X-IFU CryoAC, a large area TES-based silicon detector in a laboratory environment, and its response to the ground level flux of cosmic muons. We were able to predict the background of the Athena X-IFU instrument (ESA) in the L1 environment for an equivalent time of

$$\sim$$

∼

100 ks and used the code to investigate the dependence of such a background on possible changes in the geometry such as pixel layout and size. We also compared the results with the ones obtained for the Line Emission Mapper (LEM), a probe concept proposed to NASA that uses a different TES array optimized for higher spectral resolution of lower energy photons, identifying issues with the detector design and indicating possible solutions.
The Childbirth Experience Survey (CBEX): An Analysis of Qualitative Survey data
Authors: Saeb Samia , Korst Lisa M. , Farahnik Ferina , McCulloch Jeanette , Greene Naomi , Fridman Moshe , Gregory Kimberly D. 
Published: February 2025

Abstract

Background
In collaboration with community research partners, a national cross-sectional online Childbirth Experience Survey (CBEX) of pregnant and postpartum birthing people was administered in 2016. The linked antepartum-postpartum survey included items across 18 domains (e.g., labor management, pain management, newborn care and feeding), and identified 23 childbirth-specific postpartum patient-reported outcomes (PROs) that were associated with hospital satisfaction. CBEX was implemented in 16 California hospitals to identify hospital-specific opportunities for improvement in care. We analyzed postpartum qualitative survey responses (1) to evaluate the content validity to test the representativeness of existing CBEX domains, (2) to assess for any potential new domains or topics of interest within existing domains, and (3) to use these data to provide hospitals with actionable information for practice improvement.

Methods
This was an analysis of qualitative survey data based on the following CBEX item: “Is there anything else you would like to share about your birth experience?” Patients could provide multiple comments. Using Atlas.ti Version 8, we mapped participant responses to the 18 existing CBEX domains.

Results
Of 525 surveys completed between Oct 2018 and Sept 2020, 172 patients responded to the qualitative item. A total of 235 comments were analyzed and all were able to be mapped to the 18 domains. Qualitative responses highlighted subtleties within several CBEX domains: (1) labor management: pressure from the care team to have a labor induction; (2) pain management: epidural effectiveness, timing, dosage, and education; (3) empathy and respect: issues related to students and residents; and (4) newborn feeding: rough physical handling of patients by nurses, specifically during lactation consults.

Discussion
CBEX survey data is currently being utilized in hospitals to inform childbirth-specific quality improvement initiatives. By capturing detailed voluntary participant responses, CBEX provides the opportunity to document and explore nuanced aspects of the childbirth experience and subtleties that may be contributing to maternal dissatisfaction.
Impact of neuroinflammation on brain glutamate and dopamine signalling in schizophrenia: an update
Authors: Nayak Usha , Manikkath Jyothsna , Arora Devinder , Mudgal Jayesh 
Published: February 2025

Abstract
Schizophrenia is one of the most severe and chronic psychiatric disorders. Over the years, numerous treatment options have been introduced for schizophrenia. Although they are relatively successful in managing the positive symptoms of schizophrenia, most of the current treatments have a negligible effect on the negative and cognitive symptoms. Thus, none of them could prevent the relapse of psychotic episodes. Among the numerous hypotheses explaining the development and progression of schizophrenia, the cytokine hypothesis explains the role of inflammatory markers as a significant culprit in the development of schizophrenia. Elevated cytokines are reported in animal models and schizophrenic patients. The cytokine hypothesis is based on how increased inflammatory markers can cause changes in the dopaminergic, glutamate, and tryptophan metabolism pathways, like that observed in schizophrenic patients. Reasons, such as autoimmune disease, maternal immune activation, infection, etc., can pave the way for the development of schizophrenia and are associated with the negative, positive and cognitive symptoms of schizophrenia. Thus, there is a need to focus on the significance of anti-inflammatory drugs against these symptoms. The development of new treatment strategies in the management of schizophrenia can provide better therapeutic outcomes in terms of the severity of symptoms and treatment of drug-resistant schizophrenia. This review attempts to explain the association between elevated inflammatory markers and various neurotransmitters, and the possible use of medications like nonsteroidal anti-inflammatory drugs, monoclonal antibodies, statins, and estrogens as adjuvant therapy. Over the years, these hypotheses have been the basis for drug discovery for the treatment of schizophrenia.
Barriers and enablers to medicine-taking behaviours in chronic obstructive pulmonary disease: a qualitative interview study
Authors: Nygård Torbjørn , Wright David , Kjome Reidun L. S. , Nazar Hamde , Aarli Bernt , Raddum Aase 
Published: February 2025

Abstract

Background
Chronic Obstructive Pulmonary Disease (COPD) is associated with low health-related quality of life and high costs to healthcare systems, particularly due to hospital admissions and exacerbations. Medicines, inhalers especially, reduce the risk of hospitalisations and exacerbations, but factors influencing medicine-taking behaviours are not fully understood.

Aim
To explore experiences of people with COPD related to medicines, and followingly identify and characterise any barriers and enablers related to medicine-taking behaviours using the Theoretical Domains Framework (TDF).

Method
Semi-structured qualitative interviews were conducted and included ten people with COPD who had previously been admitted to hospital. Systematic text condensation was used inductively in the primary analysis of the interviews. In the secondary analysis, meaning units from the primary analysis were mapped to the TDF and summarised as barriers and enablers.

Results
Five major themes were developed in the primary analysis: (1) health literacy and information needs, (2) patient autonomy, (3) lack of access to medicines, (4) lack of effect from medicines, and (5) experiences of medicines-related issues. In the secondary analysis, thirteen barriers and nine enablers were mapped to nine out of the fourteen domains of the TDF.

Conclusion
People with COPD experience challenges related to medicines which need to be addressed by researchers and healthcare providers. The identified barriers and enablers mapped to the TDF can guide and inform future design of interventions and health care services.
Comment on Redstone’s “Democracy and the problem of certainty”
Authors: Sakamoto Arthur 
Published: February 2025

Abstract
Redstone (Democracy and the Problem of Certainty. Theory and Society, 2024) provides a welcomed discussion of our general psychological propensity to become overly sure of our convictions and to thereby avoid critical thinking about them. Her analysis helps us to better understand the sources of this cognitive bias and its impact on sociology which has become overly ideological. This cognitive bias is also inconsistent with Merton’s norms of science. Excessive ideological commitments and related cognitive bias are impeding the development of cumulative sociological knowledge.
Evidence of Magnetocaloric Effect in (Fe63Ni37)89B11 Nanostructured Magnetic Alloys
Authors: Garzón D. , Ostos C. , Sánchez L. C. , Marín Ramírez J. M. , Arnache O. 
Published: February 2025

Abstract
The magnetocaloric effect associated with magnetic entropy changes (ΔS

M
) and phase transitions in (Fe63Ni37)89B11 (FeNiB) powder alloys was investigated. For this purpose, the particle size of the samples was reduced under milling times of 0 (FNB) and 36 hours (FNB36). X-ray diffraction and Mössbauer spectroscopy results showed the formation of nanostructured magnetic alloys and the coexistence of γ-FCC, α-BCC, and oP-(Fe, Ni)B phases in agreement with the INVAR region. M(H) measurements revealed that both alloys are ferromagnetic soft at room temperature, with coercive field values below ~ 48 Oe. A detailed analysis of the magnetic phase transition using the modified Arrott plot and critical isotherm plots yields critical exponents (β = 0.27, γ = 0.92, and α = 4.4) close to the theoretical exponents obtained from the Tricritical Mean Field model. Moreover, a maximum magnetic entropy change (ΔS

M
) was evidenced around the phase transition (T

C
) at ~ 330 K (− ΔS

M
of 2.58 J kg−1 K−1) for FNB and ~ 415 K (− ΔS

M
of 0.4 J kg−1 K−1) for FNB36 with an applied field of 1.3 T. The relative cooling power and the temperature-averaged entropy change values were determined, and they exhibited a linear dependency as function of the external field. These findings give a good insight towards the advancements of FNB-based alloys for potential room-temperature magnetic refrigeration technology.
Aeroacoustic Process Monitoring and Anomaly Detection in Cold Spray Additive Manufacturing
Authors: Arkhipov Ivan , Kokal Uğur , Özdemir Ozan Ç. 
Published: February 2025

Abstract
Cold spray (CS) is an emerging additive manufacturing method used to deposit a wide range of materials by spraying solid particles at supersonic velocities using high-pressure millimeter scale de Laval nozzles. As CS technology finds applications in diverse areas, including 3D printing, the need for in situ process monitoring becomes increasingly apparent. The CS process is influenced by various process parameters, including nozzle gas inlet pressure, temperature, and powder feed rate. Accurately detecting variations in these parameters, as well as identifying process anomalies (e.g., nozzle wear, clogging), is crucial for the broader implementation of the technology. In situ detection of anomalous events and process health monitoring is paramount for identification of inconsistencies, ensuring product quality, enhancing cost efficiency, and reducing waste by early detection of faults. To this end, in this study, airborne acoustic emission was monitored during CS processes to discern acoustically detectable process parameters. Characteristics of aeroacoustic waves emitted under both free jet and deposition conditions were analyzed. Results indicate that changes in nozzle gas inlet pressure and temperature, powder feed rate, and nozzle wear status are discernible through acoustic power spectrum analysis. Time-domain analysis further facilitated the identification of anomalies associated with powder injection termination, deposit/substrate delamination, and nozzle geometry changes. Notably, the sliding window first order backward differentiation of total power and the power band in the time domain proved effective in detecting gradual anomalies, such as nozzle throat wear, whereas the second-order differentiation highlighted abrupt process changes, like delamination. This study demonstrates that airborne acoustic signals offer valuable insights pertaining to process faults in CS, establishing aeroacoustic signal monitoring as a promising component of stand-alone or multi-modal process monitoring for CS operations. Furthermore, the study offers invaluable insights for aeroacoustic signal feature engineering for the development of machine learning models for process monitoring in CS.
Predictive factors for successful weaning from mechanical ventilation in the internal medicine department
Authors: Cohen Gal , Bergman Idan , Atamna Alaa , Elis Avishay 
Published: February 2025

Abstract
The aging of the Israeli population along with a shortage of ICU beds have led to hospitalization of invasive mechanical ventilation patients in internal medicine departments, where, as opposed to ICU, the treatment is less than optimal. The aims of the study were to evaluate the predictive factors for successful weaning from mechanical ventilation in ventilated patients admitted to internal medicine departments. A retrospective study that included non-COVID 19 ventilated patients in internal medicine departments in a university affiliated hospital in Israel between the years 2018–2019. We compared datapoints between patients who were weaned from ventilators versus those who remained ventilated during the hospitalization, and defined demographic and clinical predictive factors for successful weaning. Data were collected from electronic medical records and included demographic, clinical, laboratory and ventilator information. The study group included 348 patients. The rate of successful weaning was 19%; patients who were successfully weaned were primarily functionally independent prior to ventilation, ventilated with low PEEP values, had high hemoglobin and albumin levels alongside with low CRP and lactate levels. Those who remained ventilated either required vasopressor treatment, had positive blood cultures or had lower GFR levels. The overall in-hospital mortality rate was 60%, while the 30-day mortality rate was lower in the extubated group [214 (76%) vs. 6 (9%), P < 0.0001]. Our findings highlight the low rate of weaning from ventilation in the department of medicine, with higher mortality rate among the remained ventilated patients. Various favorable clinical parameters might predict successful weaning.
A new approach for the Brown–Erdős–Sós problem
Authors: Shapira Asaf , Tyomkyn Mykhaylo 
Published: February 2025

Abstract
The celebrated Brown–Erdős–Sós conjecture states that for every fixed e, every 3-uniform hypergraph with Ω(n
2) edges contains e edges spanned by e + 3 vertices. Up to this date all the approaches towards resolving this problem relied on highly involved applications of the hypergraph regularity method, and yet they supplied only approximate versions of the conjecture, producing e edges spanned by e + O(log e/ log log e) vertices.
In this short paper we describe a completely different approach, which reduces the problem to a variant of another well-known conjecture in extremal graph theory. A resolution of the latter would resolve the Brown–Erdős–Sós conjecture up to an absolute additive constant.
Engaging citizen scientists: designing an open research system for collaborative problem exploration
Authors: Gau Michael , Greif-Winzrieth Anke , Maedche Alexander , Weinhardt Christof , vom Brocke Jan 
Published: February 2025

Abstract
Open Science aims to make scientific research and its dissemination accessible to all levels of society to foster openness and transparency. Engaging in a dialogue with society to explore real-world problems is particularly important to increase the relevance of information systems research. However, reaching out to citizens and engaging them in the research problem exploration process on a large scale is challenging for researchers. In this research, we build on existing prescriptive knowledge and design an open research system to involve citizens in the problem exploration process. Applying the design science research methodology, we report on the results and findings of one complete design cycle. We deliver design knowledge including (1) design requirements derived from the literature, (2) propose a set of design principles, (3) an instantiation of the design principles in the form of design features as well as a publicly available artifact, and (4) evaluations through a series of online experiments and two field studies with actual citizens. With this research project, we contribute design knowledge for the class of citizen science systems and present an approach and a publicly available instantiation that can be leveraged for open research problem exploration to engage with society members at large.