bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal differences in water quality of highland lakes and its influencing factors: A case study of Dianchi Lake
Authors: Liu Chenyang , Zhang Zhuoya , Li Jiaxi , Ge Hailong , Xing Yajiao 
Published: November 2023

Abstract

Water quality is of great significance to human survival and development. It is of good theoretical value to study seasonal water quality variation and driving factors in plateau lakes. This paper studied the variation of water quality parameters in different seasons and their relationship with land use and climate factors in Dianchi Lake, Yunnan Province from 2001 to 2019. The results show that the factors restricting water environment in different seasons are different, but basically close. The water quality parameters of multiple water quality monitoring stations in different seasons showed a decreasing or insignificant trend. In the rainy season, the temperature and precipitation were positively correlated with most water quality parameters, while the driving effect of climate factors was not significant in the dry season. Different land types have different effects on water quality indexes in different seasons. The water quality score was higher in the rainy season than in the dry season. The scores of water quality stations in the south and middle of Dianchi Lake are higher than those in the north. In this study, the relationship between climate, land, and water quality is established, which provides a way for the research of water quality parameters.
Kisspeptin and its Current Clinical Status-A Systematic Review
Authors: Velmurugan Hemasri , Mannava Anjali Srikanth , Thangaraju Pugazhenthan , Neelambaran Krishnapriya 
Published: November 2023

Background:
Kisspeptin was initially known as metastin for its role in suppressing
metastasis in melanoma and breast cancer. Later, based on its ability to stimulate
GPR54, its importance in maintaining an intact hypothalamic-pituitary-ovarian axis
was recognised, which is the basis for the widespread application of the drug in several
conditions such as secondary amenorrhea, regulation of puberty onset, ovarian function,
trophoblast invasion, fertility regulation, parturition, and lactation. This systematic study
aims to evaluate the current status of kisspentin in clinical trials.

Methods:
The keywords 'kisspeptin' or 'metastin' were used in the clinicaltrials.gov website
and Clinical Trial Registry of India (CTRI) to find eligible clinical trials or records
carried out without time constraints until February 26, 2023.

Results:
A total of 33 records were identified through clinical trial databases. All records
were screened, and four trials were rejected as they failed to meet the inclusion criteria.
Finally, 29 (87.9%) reports of interventional clinical trials with kisspeptin were reviewed.

Conclusion:
Kisspeptin can be viewed as a multipurpose drug with considerably fewer
side effects due to its effects simulating normal physiological processes in our body.
Recent Progress in the Hesperetin Delivery Regimes: Significance of Pleiotropic
Actions and Synergistic Anticancer Efficacy
Authors: Malik Parth , Bernela Manju , Seth Mahima , Kaushal Priya , Mukherjee Tapan Kumar 
Published: November 2023

Background:
In the plant kingdom, flavonoids are widely distributed with multifunctional immunomodulatory
actions. Hesperetin (HST) remains one of the well-studied compounds in this domain, initially
perceived in citrus plants as an aglycone derivative of hesperidin (HDN).

Observations:
Natural origin, low in vivo toxicity, and pleiotropic functional essence are the foremost fascinations
for HST use as an anticancer drug. However, low aqueous solubility accompanied with a prompt degradation
by intestinal and hepatocellular enzymes impairs HST physiological absorption

Motivation:
Remedies attempted herein comprise the synthesis of derivatives and nanocarrier (NC)-mediated
delivery. As the derivative synthesis aggravates the structural complexity, NC-driven HST delivery has
emerged as a sustainable approach for its sustained release. Recent interest in HST has been due to its significant
anticancer potential, characterized via inhibited cell division (proliferation), new blood vessel formation
(angiogenesis), forceful occupation of neighboring cell’s space (invasion), migration to erstwhile physiological
locations (metastasis) and apoptotic induction. The sensitization of chemotherapeutic drugs (CDs) by HST
is driven via stoichiometrically regulated synergistic actions.

Purpose and Conclusion:
This article sheds light on HST structure-function correlation and pleiotropic anticancer
mechanisms, in unaided and NC-administered delivery in singular and with CDs synergy. The discussion
could streamline the HST usefulness and long-term anticancer efficacy.
Effectiveness of Chinese Herbal Medicine in Postoperative Fatigue
Syndrome Following Total Joint Arthroplasty or Hip Fracture Surgery:
Evidence from Randomized Controlled Trials
Authors: Zhao Jinlong , Zhou Guanghui , Wang Zhongsheng , Liang Guihong , Wei Xingde , Sha Bangxin , Yang Weiyi , Liu Jun , Chen Hongyun 
Published: November 2023

Background::
There is no high-quality, evidence-based protocol for the treatment of
postoperative fatigue syndrome (POFS) after total joint arthroplasty (TJA) or fracture surgery with
Chinese herbal medicine (CHM).

Purpose::
The purpose of this study was to explore the efficacy of CHM in the treatment of POFS
after TJA or hip fracture surgery (HFS).

Methods::
We searched six databases to obtain randomized controlled trials (RCTs) of CHM for
the treatment of POFS after TJA or HFS. The retrieval time limit was from the establishment of
each database to August, 2022. According to the Cochrane Handbook for Systematic Reviews
version 5.1, we used RevMan 5.3 to evaluate the quality of the studies. Stata 14.0 software was
used to merge and analyze the data. The weighted mean difference (WMD) was the effect estimate
for statistical analysis. We also performed subgroup analyses according to different types of surgeries.

Results::
A total of 11 RCTs were included in this study, comprising 430 cases in the CHM group
and 432 cases in the control group (CG). The meta-analysis results showed that there was no significant
difference in the Brief Profile of Mood States (BPOMS) score (WMD=0.08, 95% confidence
interval (CI): -0.29 to 0.45, P=0.688), Christensen Fatigue scale (CHFS) score (WMD =
0.15, 95% CI: -0.09 to 0.39, P=0.214) or Identity-Consequence Fatigue Scale (ICFS) score
(WMD=-0.40, 95% CI: -1.84 to 1.05, P=0.589) between the CHM group and the CG on the first
postoperative day. The use of CHM significantly reduced the BPOMS score (WMD=-0.85 and
WMD=-3.01, respectively), CHFS score (WMD=-1.01 and WMD= -1.45, respectively), and ICFS
score (WMD=-3.51 and WMD=-5.26) on postoperative days 3 and 7. Compared with the CG, the
CHM group had significantly increased serum transferrin and IgG levels on postoperative days 3
and 7. The subgroup analysis results suggested that the application of CHM in HFS patients improved
fatigue symptoms on postoperative days 3 and 7, while the application of CHM to treat
POFS in TJA patients had great inconsistency in the evaluation of different indicators.

Conclusion::
The application of CHM improved the fatigue status of POFS patients after TJA or
HFS and increased the levels of transferrin and IgG in serum, which is conducive to promoting the
postoperative rehabilitation process of patients. The subgroup analysis results showed that the application
of CHM to intervene in POFS in HFS patients had obvious benefits.
Bioactive Exploration in Functional Foods: Unlocking Nature's Treasures
Authors: Mittal Ravi K. , Mishra Raghav , Sharma Vikram , Purohit Priyank 
Published: November 2023

Background::
Functional foods offer an appealing way to improve health and prevent
chronic diseases, and this subject has received much attention lately. They are effective in preventing
chronic diseases like cancer, diabetes, heart disease, and obesity, according to research.

Objective::
This work presents an in-depth analysis of functional foods, covering key challenges
from a scientific, legal, and commercial perspective.

Methods::
Multiple databases were searched to find studies on functional foods included in the
systematic literature review. Various aspects of functional foods, from their classification, impact
on human wellness, effectiveness in inhibiting chronic diseases, the regulatory environment,
global market trends, and industry challenges, are all clarified in this thorough review.

Results::
This study aims to enhance understanding and establish a pathway for functional foods
to be acknowledged as valid choices in the field of dietary supplements. It provides a thorough
investigation of bioactive compounds present in functional foods, including but not limited to
polyphenols, carotenoids, omega fatty acids, prebiotics, probiotics, and dietary fiber, along with
an overview of their potential to mitigate chronic illnesses. We engage in an in-depth exploration
of regulatory frameworks, shed light on groundbreaking research advancements, and meticulously
examine strategies for commercialization and the variety of global challenges that accompany
them. Establishing scientific consensus, navigating complex regulatory processes, dealing with
skeptical consumers, and rising levels of competition are all problems that need to be solved in
this field.

Conclusion::
The field of functional foods can advance further, promoting better public health
outcomes, by deeply comprehending and addressing these complex dimensions.
Beta-blockers in Hypertensive Left Ventricular Hypertrophy and Atrial
Fibrillation Prevention
Authors: Koraćević Goran , Mićić Sladjana , Stojanović Milovan , Zdravkovic Marija , Simić Dragan , Kostić Tomislav , Atanasković Vesna , Janković-Tomašević Ružica 
Published: November 2023

Background:
Hypertensive left ventricular hypertrophy (HTN LVH) is a key risk factor
for atrial fibrillation (AF).

Objective:
To evaluate the possible role of beta-blockers (BBs) in addition to a renin-angiotensinaldosterone
system (RAAS) blocker in AF prevention in patients with HTN LVH.

Methods:
We performed a PubMed, Elsevier, SAGE, Oxford, and Google Scholar search with the
search items ‘beta blocker hypertension left ventricular hypertrophy patient’ from 2013-2023. In the
end, a ‘snowball search’, based on the references of relevant papers as well as from papers that cited
them was performed.

Results:
HTN LVH is a risk factor for AF. In turn, AF substantially complicates HTN LVH and contributes
to the genesis of heart failure (HF) with preserved ejection fraction (HFpEF). The prognosis
of HFpEF is comparable with that of HF with reduced EF (HFrEF), and, regardless of the type, HF is
associated with five-year mortality of 50-75%. The antiarrhythmic properties of BBs are wellrecognized,
and BBs as a class of drugs are - in general - recommended to decrease the incidence of
AF in HTN.

Conclusion:
BBs are recommended (as a class) for AF prevention in several contemporary guidelines
for HTN. LVH regression in HTN - used as a single criterion for the choice of antihypertensive medication
- does not capture this protective effect. Consequently, it is worth studying how meaningful
this antiarrhythmic action (to prevent AF) of BBs is in patients with HTN LVH in addition to a
RAAS blocker.
Treatment of Menopausal Symptoms with Herbal Medicines: A Review
Authors: Wal Pranay , Singh Indu , Singh Deependra , Singh Manju Rawat , Wal Ankita 
Published: November 2023

Background:
Menopause refers to the natural process of the “cessation of the menstrual
cycle.” This phase predominantly affects aged women and can lead to various symptoms such
as hot flashes, insomnia, night sweats, and sexual dysfunction, among others. Unfortunately,
many women remain unaware of this condition, and some even choose to overlook the symptoms.
However, those who recognize the symptoms consult with a doctor, who may recommend Hormone
replacement therapy (HRT). Initially, Hormone replacement therapy (HRT) can be effective,
but prolonged use can result in side effects. To mitigate these effects, there is a need to explore
and investigate herbal therapies as an alternative treatment for menopausal symptoms.

Objective:
The objective of this review is to explore and summarize various herbs used in managing
menopausal symptoms as an alternative to hormone replacement therapy.

Methods:
For this review, we conducted a literature survey spanning from 1998 to 2023. We used
keywords such as menopause, endocrinology, hormone replacement therapy, and herbs used for reducing
menopausal symptoms to search databases such as Google Scholar, PubMed, and SciDirect.
Relevant data were sourced from various journals like Plos One, JAMA, Frontier, Drug in
Context, MDPI, Molecules, BMC Women's Health, Research Gate, Heliyon, Elsevier, Taylor &
Francis, Nutrients, JMM, Wiley, OXFORD, Hindawi, Clinical Phytoscience, Pharmaceuticals,
Phytomedicine, and Menopause: The Journal of The North American Menopause Society.

Results:
The literature review encompassed 40 research articles and 200 review articles, including
randomized controlled trials. The findings revealed that several herbal plants, including Curcuma
longa, Zingiber officinale, Foeniculum vulgare, Trigonella foenum, Actaea racemosa, Glycyrrhiza
glabra, Oenothera biennis, Trifolium pratense, Humulus lupulus, Vitex agnus-castus, Valeriana officinalis,
Linum usitatissimum, Cannabis sativa, and Asparagus racemosus, have shown efficacy
in treating menopausal symptoms.

Conclusion:
In conclusion, medicinal plants can play a significant role in managing acute menopausal
syndrome. The intent of this review is to highlight the most recent research on estrogenic
plants for medicinal purposes and their therapeutic impact on cognitive deficiencies brought on by
estrogen shortage during menopause and aging.
Imaging Changes in Liver After Chemotherapy for Colon Cancer: A Case
Report
Authors: Lu Xuelin , Yang Shiping , Li Ting , Qin Zuoan , Zheng Chao 
Published: November 2023

Background::
Colon cancer with liver metastasis is a common occurrence in clinical practice. The presence of liver metastasis has a significant impact on the
treatment strategy of patients, so the first step is to diagnose whether it is liver metastasis. Imaging is one of the auxiliary methods for diagnosing
liver metastases, but due to the presence of different diseases with the same shadow, we need to be cautious when using imaging methods for the
diagnosis of liver metastases.

Case Presentation::
We report a 53-year-old female patient with sigmoid colon cancer and perforation who underwent a surgical operation. Three years after the
operation, reexamination of the liver through computed tomography and magnetic resonance imagery scanning revealed multiple progressive liver
lesions. However, the liver biopsy did not show malignant changes. Repeated analysis of the patient's liver magnetic resonance imaging revealed
that multiple liver nodules were significantly enhanced in the arterial phase and that the portal vein density/signal ratio was higher than that of the
liver parenchyma. The coincidence of doughnut-shaped nodules and high signal in the hepatobiliary phase, combined with the results of
pathological liver puncture examination, led to nodular regenerative hyperplasia being considered as a possible diagnosis.

Conclusion::
A review of the relevant literature showed that following oxaliplatin chemotherapy for colorectal cancer, it is not uncommon for doughnut-shaped
nodules with obvious enhancement in the middle hepatic artery phase and high signal intensity in the hepatobiliary phase to develop. Such changes
should be paid sufficient attention by radiologists.
Bioactive Secondary Metabolites Produced by the Hadal Actinomycete
Streptomyces sp. SY1414 Isolated from the Mariana Trench-derived Sediment
Authors: Zhang Di , Feng Yao , Li Huifang , Zhang Zhizhen 
Published: November 2023

Background::
Accumulated investigations have demonstrated that the Mariana Trench is
enriched in microorganisms. However, the diversity of structures and bioactivities of the secondary
metabolites produced by the Mariana Trench-associated microorganisms is poorly known, which
needs to be intensively investigated.

Objective::
This study aimed to investigate the bioactive secondary metabolites produced by a Mariana
Trench-derived actinomycete Streptomyces sp. SY1414 was cultured in BY medium, which was
chosen from four different media based on the diversity of secondary metabolites.

Methods::
A combination of different column chromatographs and HPLC was applied for the separation
and purification of the secondary metabolites. The structures of the isolated compounds were
determined mainly based on their NMR data, optical rotation values, and the comparison with the
reference data, and the Sulforhodamine B (SRB) method was used to evaluate the anti-glioma activity
of isolated compounds.

Results::
Four different types of compounds were isolated from the large culture of strain Streptomyces
sp. SY1414 in BY medium, including a benzoquinoline alkaloid, actinophenanthroline C (1), a
benzamide, (2E,4E)-5-(3-hydroxyphenyl)-penta-2,4-dienamide (2), a cyclopeptide, valinomycin (3),
and four macrolides of bafilomycin D (4), bafilomycin A2 (5), bafilomycin W (6), and C(19), C(21)-
O-methyl-bafilomycin A1 (7). Actinophenanthroline C (1), bafilomycin D (4), bafilomycin A2 (5),
and bafilomycin W (6) displayed significant anti-glioma activities with IC50 values ranging from
1.62 to 8.20 μM for U87MG cells and 2.45 to 3.89 μM for U251. The anti-gliomas of actinophenanthroline
C (1) was reported for the first time.

Conclusion::
The hadal actinomycete Streptomyces sp. SY1414 in BY medium produced four different
types of secondary metabolites with significant anti-glioma activity, which enriched the diversity
of structures and bioactivities of the Mariana Trench-associated natural products.
A Hidden Pandemic? Abuse of Gabapentinoids: A Brief Review of Recent Studies
Authors: Ispir Gamze Zengin , Danısman Mustafa , Katar Kubra Sezer 
Published: November 2023

Background:
Gabapentin and pregabalin were developed for epilepsy and neuropathic
pain. They work via voltage-gated calcium channels and are used for broad-spectrum
diagnoses, e.g., epilepsy, neuropathic pain, other chronic pain syndromes, anxiety disorders,
alcohol-drug withdrawal syndromes, agitation, insomnia, etc. Especially in a world dealing with
the opioid crisis, gabapentinoids were considered safer alternatives to opioid analgesics.

Methods:
This review aims to comprehensively search and summarize recent studies concerning
the abuse of gabapentinoids published between 2021 and 2022 from various regions around
the world.

Results:
Studies have highlighted that a history of substance use disorder is a significant risk
factor for gabapentinoid abuse. Concurrent abuse of gabapentinoids with illicit drugs can exacerbate
drug-related damages. Drug screening and postmortem toxicology tests have revealed an
increase in gabapentinoid consumption. In response to the abuse potential, several countries
have classified gabapentinoids as controlled substances.

Conclusion:
Gabapentinoids are highly abused molecules worldwide. Physicians should be
aware of their abuse potential.
Identification and Phylogenetic Analysis of Venom Allergens from
Transcriptome of Hemiscorpius lepturus Scorpion
Authors: Kazemi-Lomedasht Fatemeh , Shahbazzadeh Delavar , Behdani Mahdi 
Published: November 2023

Introduction:
Venom allergens have been identified in the venom of scorpion, snake, bee,
wasp, etc. Some allergy reactions in humans may refer to the venom allergens.

Aim:
Phylogenetic analysis of venom allergens from the transcriptome of Hemiscorpius lepturus scorpion was the main aim of the study.

Methods:
Seven venom allergens: HLAllergen1, HLAllergen2, HLAllergen3, HLAllergen4, HLAllergen5, HLAllergen6, and HLAllergen7 have been identified in the venom of Hemiscorpius lepturus
scorpion using venom gland transcriptome analysis. Primary, secondary and tertiary structures of the
identified venom allergens were predicted using ExPASy ProtParam, PSIPRED, and SWISS MODEL
servers. Phylogenetic tree was constructed using MEGA 11 software through neighbor-joining method
with 1000 bootstraps.

Results:
Structure analysis of identified venom allergens showed a molecular weight of between 46 to
52 kDa. Tertiary structure results showed that all predicted 3-D structures were in a normal range.
Phylogenetic tree analysis showed that HLAllergen 3, 4 and 5 were formed single clades and HLAllergen 1, 2, 7, and 6 other clades

Conclusion:
However, further studies using proteomic analysis of H. lepturus are needed to confirm
and compare with transcriptome data.
The Prospects of Lampung's Pepper Export to the Global Market: An Analysis Using the ARIMA Model
Authors: Putri Najah Hanifah , Abidin Zainal , Situmorang Suriaty 
Published: November 2023

Pepper is one of Lampung's leading export commodities. It can be seen from the contribution of Lampung Province's pepper, which accounted for 42 percent of Indonesia's overall pepper exports. However, pepper production and export volume in Lampung Province continue to decline annually. This study aims to analyze the prospect of Lampung’s pepper export to the international market for ten years, from 2023 - 2033. This research used ARIMA (Auto Regressive Moving Average) t model tool using E-views statistical software to forecast the trend of export of Lampung pepper to the International market. The data used was secondary data from the quarterly export of Lampung’s pepper from 2002 to 2022. The study suggested that Lampung's pepper exports are projected to decrease from 2023 to 2033, with a decrease of 10 percent each year. Finally, in 2033, Lampung's pepper exports to the international market only reached 998 tons.