bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Medicaid Privatization With Patient Cancer Outcomes
Authors: Sunkara Pranit R. , Waitzman Jacob , Lenze Nicholas R. , Brenner Michael J. , Cramer John D. 
Published: January 2024

PURPOSE
Increasingly, states outsource administration of Medicaid insurance to privately administered Medicaid managed care organizations. However, on January 1, 2012, Connecticut transitioned from a privately to publicly administered Medicaid system. New Jersey retained a private model.

METHODS
Our objective was to assess rates of early-stage cancer diagnosis and cancer survival in two states with similar sociodemographic characteristics but differing exposures to Medicaid privatization. Using data from the SEER Program between 2007 and 2016, Connecticut and New Jersey Medicaid patients with 10 common solid cancers including breast, lung, colorectal, prostate, kidney, bladder, cervix, uterus, head and neck cancer, and melanoma were included. A difference-in-differences analysis of stage of cancer presentation and cancer survival in Connecticut (intervention) was compared with New Jersey (control).

RESULTS
Among 29,328 patients (14,424 patients from Connecticut and 14,904 patients from New Jersey) parallel trends were verified in early cancer diagnosis and survival for both states under privately administered Medicaid (pre-exposure). Connecticut's transition from privately to publicly administered Medicaid was associated with an adjusted 4.0% increase in overall early-stage cancer diagnosis (95% CI, +1.7% to +6.2%) and a 4.7% increase in early-stage cancer diagnosis for cancers with US Preventive Services Taskforce A/B recommendations for cancer screening (95% CI, 1.6% to 7.8%). Public administration of Medicaid was also associated with improved overall survival after cancer diagnosis (hazard ratio, 0.92 [95% CI, 0.85 to 0.99]). No changes were observed in New Jersey.

CONCLUSION
Transition from private to public administration of Medicaid in Connecticut was associated with earlier-stage cancer diagnosis and improved cancer survival.
Establishing Regionalized Acute Care Across a Health Care System to Decentralize Postoperative Care After Oncologic Surgery
Authors: Brauer David G. , Gonen Mithat , Drebin Jeffrey A. , Groeger Jeffrey S. , Jewell Elizabeth L. 
Published: January 2024

PURPOSE Patients undergoing oncologic surgery at major referral centers frequently experience postdischarge care fragmentation, which has been associated with poor outcomes. This report describes and evaluates the outcomes of an intervention at Memorial Sloan Kettering Cancer Center (MSKCC) to decentralize postdischarge postoperative acute care within our health care system. METHODS In 2018, MSKCC completed the addition of six regional acute care clinics called symptom care clinics (SCCs) to existing regional outpatient clinics. Acute care was previously only available within our system at a single centralized urgent care center (UCC). All patients undergoing surgery in our system between January 1, 2019, and June 30, 2021, were followed for 90 days. The exposure was the site of initial acute care presentation—UCC or SCC—and outcomes included utilization, access, financial toxicity, and mortality. Mortality was adjusted using hierarchical modeling at the level of the region. RESULTS A total of 6,992 postsurgical patients experienced 10,525 acute care visits in our system within 90 days of surgery. Twenty-nine percent of these patients presented to the SCC first. These patients were older but had fewer comorbidities and shorter index length of stay compared with UCC patients. Utilization of SCCs increased substantially while UCC utilization decreased during a period of stable case volume. SCCs were closer to patients' homes, and wait times were shorter. Rates of financial toxicity were similar between groups. Of this high-risk cohort accessing acute care postoperatively, 90-day mortality was similar for UCC and SCC patients ( P = .731). CONCLUSION This model of decentralized acute care after oncologic surgery was increasingly used over time with comparable patient safety. Health systems should emphasize patient-centered care by supporting safe strategies for regionalized care even when treatments are delivered at centralized referral centers.
Liquid Biopsy of Lung Cancer Before Pathological Diagnosis Is Associated With Shorter Time to Treatment
Authors: Russo Alessandro , Lee Jessica K. , Pasquina Lincoln W. , Del Re Marzia , Dilks Holli H. , Murugesan Karthikeyan , Madison Russell W. , Lee Yi , Schrock Alexa B. , Comment Leah , Dietrich Martin , Oxnard Geoffrey R. , Rolfo Christian 
Published: January 2024

PURPOSE Studies have investigated the early use of liquid biopsy (LBx) during the diagnostic workup of patients presenting with clinical evidence of advanced lung cancer, but real-world adoption and impact has not been characterized. The aim of this study was to determine whether the use of LBx before diagnosis (Dx; LBx-Dx) enables timely comprehensive genomic profiling (CGP) and shortens time until treatment initiation for advanced non–small-cell lung cancer (aNSCLC). MATERIALS AND METHODS This study used the Flatiron Health-Foundation Medicine electronic health record-derived deidentified clinicogenomic database of patients with aNSCLC from approximately 280 US cancer clinics. RESULTS Of 1,076 patients with LBx CGP ordered within 30 days prediagnosis/postdiagnosis, we focused on 56 (5.2%) patients who ordered LBx before diagnosis date (median 8 days between order and diagnosis, range, 1-28). Compared with 1,020 patients who ordered LBx after diagnosis (Dx-LBx), LBx-Dx patients had similar stage and ctDNA tumor fraction (TF). LBx-Dx patients received CGP results a median of 1 day after Dx versus 25 days for Dx-LBx patients. Forty-three percent of LBx-Dx were positive for an National Comprehensive Cancer Network driver, and 32% had ctDNA TF >1% but were driver negative (presumed true negatives). In 748 patients with previously untreated aNSCLC, median time from Dx to therapy was shorter in the LBx-Dx versus Dx-LBx group (21 v 35 days; P < .001). CONCLUSION Early LBx in anticipation of pathologic diagnosis of aNSCLC was uncommon in this real-world cohort, yet this emerging paradigm was associated with an abbreviated time to CGP results and faster therapy initiation. Forthcoming prospective studies will clarify the utility of LBx in parallel with biopsy for diagnostic confirmation for patients presenting with suspected advanced lung cancer.
“To Repulse the State from Our Uteri”
Authors: Beswick Spencer 
Published: January 2024

AbstractThis article analyzes how anarcha-feminists in the United States critiqued the state and attempted to build feminist dual power in response to the New Right’s attacks on reproductive freedom. Anarcha-feminists in the Love and Rage Revolutionary Anarchist Federation (1989–98) argued that petitioning the state for reproductive rights was a dead end because, as their political statement put it, patriarchy “operates as a foundation of state power, used to justify a paternalistic relationship between the rulers and the ruled.” Anything the state gives—including Roe v. Wade—can be taken away, for it is ultimately a tool of sexual and class violence in the hands of the patriarchal, capitalist ruling class. Building on the legacy of anarcha-feminists in the women’s liberation movement, Love and Rage argued that the only way to guarantee reproductive freedom was to struggle for autonomy against the state rather than reform within it. This article explores how anarcha-feminists sought to build grassroots infrastructure, knowledge, and organizations with an orientation toward establishing feminist dual power. Ultimately, Love and Rage argued, the only way to guarantee reproductive freedom and women’s liberation is the revolutionary construction of a libertarian socialist society.
Kuzey Kıbrıs’ta Yeni-Kabileci Milliyetçiliğin Yükselişi: Göç ve Tarih Yazıcılığı Tartışmaları
Authors: ÇOLAK Yılmaz , ŞAHİN Yakup , ÖZDEMİR ÇOLAK Aysel 
Published: January 2024

Bu çalışma Kuzey Kıbrıs’ta kimlik ve milliyetçilik tartışmalarını yeni bir analitik çerçeve olan ‘yeni-kabileci milliyetçilik’ temelinde incelemektedir. Kıbrıs’ta özellikle İngiliz sömürgesiyle birlikte karşılıklı
rekabet içinde olan Rum ve Türk milliyetçilikleri 1960’lardan itibaren yeni bir dönüşüm yaşamış ve 1974’ten sonra da yeni bir evreye girmiştir. Adanın her iki kesimindeki hâkim iki resmî milliyetçi konuma yerlici alternatif bir ideoloji olarak ‘Kıbrıs milliyetçiliği’ ya da ‘Kıbrısçılık’ ortaya çıkıp gelişmiştir. Özellikle KKTC’de sol siyasetin ideolojisi olarak dillendirilen Kıbrısçılık 2000’li yıllarla birlikte küreselleşme ve AB üyelik süreçleri etkisi altında gittikçe güçlenmiş, toplum ve siyaset düzeyinde belirleyici hâle gelmiştir. Bu makale, Kıbrıs özelinde milliyetçilik üzerine yapılan çalışmalarda sıklıkla referans verilen etnik ve sivil milliyetçilik zıtlığının Kıbrıs’ta yaşanan dönüşümü açıklamada yetersiz kaldığını ileri sürmekte ve Kıbrıslı kimliği inşa etme anlamında Kıbrısçı yerliciliği merkeze alarak seçmeci bir şekilde mitler yoluyla kurgulanmış bir geçmişe dayalı hayali bir cemaat yaratması, göçmenlere karşı ötekileştirici söylem ve eylemlerle ayrımcı ve dışlayıcı olması bakımlarından Kıbrısçılığı ‘yeni-kabileci milliyetçilik’ olarak değerlendirmektedir. Bu inceleme KKTC’de göç ve tarih yazımı tartışmaları üzerinden yapılmaktadır.
İlk Yazılı Kaynaklarına Göre Oğuzlar Teŋri mi Yoksa Taŋrı mı Diyordu?
Authors: SALAN Erkan 
Published: January 2024

Eski Anadolu Türkçesi ile ilgili yayımlarda bir sözcüğün taŋrı (/tan͡grı) ve teŋri (/ten͡gri) şeklinde iki farklı biçimiyle karşılaşılır. Hatta bazen aynı eserde hem taŋrı (/tan͡grı) hem de teŋri (/ten͡gri)
biçiminde ikili okumaların yer aldığı görülür. Farklı okuma ve kabuller, karışıklık oluşturmakla birlikte aynı sözcüğün sözü edilen dönemde iki farklı fonetik varyanta sahip olduğunun düşünülmesine
imkân vermektedir. Var olan bu görünüm, niçin taŋrı ya da niçin teŋri okunması gerektiği konusunda bir kısım tespit ve değerlendirmelerin yapılmasını gerekli hâle getirmiştir. Aynı tarihî
dönemde bir sözcüğün, herhangi bir sebebe bağlanmaksızın iki farklı biçimde okunması dil araştırmaları ve dönemin dil özellikleri bakımından sorun teşkil etmektedir. Eski Anadolu Türkçesinde
teŋri biçiminin mi yoksa taŋrı biçiminin mi kullanıldığını tespit etmeyi amaçlayan bu çalışmayla ortaya çıkan sonuç; adı geçen dönemde teŋri biçiminin bulunmadığı ve Oğuzların, ilk yazılı
kaynaklarından itibaren sözcüğü taŋrı şeklinde kalın ünlülü olarak telaffuz ettikleri yönündedir.
Hematuria after nocturnal exercise of a man: A case report
Authors: Bai Ming-Jian , Yang Song-Tao , Liu Xue-Kai 
Published: January 2024

BACKGROUND
A man experienced multiple episodes of macroscopic hematuria following nocturnal exercise. Urinary stones and tumors were considered the two most likely causes. The patient had two hobbies: Consuming health care products in large quantities and engaging in late-night running.
CASE SUMMARY
Health care products contain a large amount of calcium phosphate, and we hypothesize that this could induce the formation of small phosphate stones. After exercise, the urinary system is abraded, resulting in bleeding. The patient was advised to stop using the health care products. Consequently, the aforementioned symptoms disappeared immediately. However, the patient resumed the above two habits one year later; correspondingly, the macroscopic hematuria reappeared.
CONCLUSION
This finding further confirmed the above inference and allowed for a new avenue to determine the cause of the patient’s hematuria.
Causal associations between gastroesophageal reflux disease and essential hypertension: A bidirectional Mendelian randomization study
Authors: Wei Ning , Liu Ming-Hui , Song Yu-Hu 
Published: January 2024

BACKGROUND
Clinical studies have reported that patients with gastroesophageal reflux disease (GERD) have a higher prevalence of hypertension.
AIM
To performed a bidirectional Mendelian randomization (MR) analysis to investigate the causal link between GERD and essential hypertension.
METHODS
Eligible single nucleotide polymorphisms (SNPs) were selected, and weighted median, inverse variance weighted (IVW) as well as MR egger (MR-Egger) regression were used to examine the potential causal association between GERD and hypertension. The MR-Pleiotropy RESidual Sum and Outlier analysis was used to detect and attempt to reduce horizontal pleiotropy by removing outliers SNPs. The MR-Egger intercept test, Cochran’s Q test and “leave-one-out” sensitivity analysis were performed to evaluate the horizontal pleiotropy, heterogeneities, and stability of single instrumental variable.
RESULTS
IVW analysis exhibited an increased risk of hypertension (OR = 1.46, 95%CI: 1.33-1.59, P = 2.14E-16) in GERD patients. And the same result was obtained in replication practice (OR = 1.002, 95%CI: 1.0008-1.003, P = 0.000498). Meanwhile, the IVW analysis showed an increased risk of systolic blood pressure (β = 0.78, 95%CI: 0.11-1.44, P = 0.021) and hypertensive heart disease (OR = 1.68, 95%CI: 1.36-2.08, P = 0.0000016) in GERD patients. Moreover, we found an decreased risk of Barrett's esophagus (OR = 0.91, 95%CI: 0.83-0.99, P = 0.043) in essential hypertension patients.
CONCLUSION
We found that GERD would increase the risk of essential hypertension, which provided a novel prevent and therapeutic perspectives of essential hypertension.
Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis
Authors: An Wen-Ting , Hao Yu-Xia , Li Hong-Xia , Wu Xing-Kang 
Published: January 2024

BACKGROUND
Helicobacter pylori (H. pylori ) infection is a major risk factor for chronic gastritis, affecting approximately half of the global population. H. pylori eradication is a popular treatment method for H. pylori -positive chronic gastritis, but its mechanism remains unclear. Urinary metabolomics has been used to elucidate the mechanisms of gastric disease treatment. However, no clinical study has been conducted on urinary metabolomics of chronic gastritis.
AIM
To elucidate the urinary metabolic profiles during H. pylori eradication in patients with chronic gastritis.
METHODS
We applied LC–MS-based metabolomics and network pharmacology to investigate the relationships between urinary metabolites and H. pylori -positive chronic gastritis via a clinical follow-up study.
RESULTS
Our study revealed the different urinary metabolic profiles of H. pylori -positive chronic gastritis before and after H. pylori eradication. The metabolites regulated by H. pylori eradication therapy include cis-aconitic acid, isocitric acid, citric acid, L-tyrosine, L-phenylalanine, L-tryptophan, and hippuric acid, which were involved in four metabolic pathways: (1) Phenylalanine metabolism; (2) phenylalanine, tyrosine, and tryptophan biosynthesis; (3) citrate cycle; and (4) glyoxylate and dicarboxylate metabolism. Integrated metabolomics and network pharmacology revealed that MPO, COMT, TPO, TH, EPX, CMA1, DDC, TPH1, and LPO were the key proteins involved in the biological progress of H. pylori eradication in chronic gastritis.
CONCLUSION
Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of H. pylori -positive chronic gastritis patients.
Abnormal uterine bleeding successfully treated via ultrasound-guided microwave ablation of uterine myoma lesions: Three case reports
Authors: Kakinuma Toshiyuki , Kakinuma Kaoru , Okamoto Rora , Yanagida Kaoru , Ohwada Michitaka , Takeshima Nobuhiro 
Published: January 2024

BACKGROUND
Microwave endometrial ablation (MEA) is a minimally invasive treatment method for heavy menstrual bleeding. However, additional treatment is often required after recurrence of uterine myomas treated with MEA. Additionally, because this treatment ablates the endometrium, it is not indicated for patients planning to become pregnant. To overcome these issues, we devised a method for ultrasound-guided microwave ablation of uterine myoma feeder vessels. We report three patients successfully treated for heavy menstrual bleeding, secondary to uterine myoma, using our novel method.
CASE SUMMARY
All patients had a favorable postoperative course, were discharged within 4 h, and experienced no complications. Further, no postoperative recurrence of heavy menstrual bleeding was noted. Our method also reduced the myoma’s maximum diameter.
CONCLUSION
This method does not ablate the endometrium, suggesting its potential application in patients planning to become pregnant.
Statistical integration of multi-omics and drug screening data from cell lines
Authors: el Bouhaddani Said , Höllerhage Matthias , Uh Hae-Won , Moebius Claudia , Bickle Marc , Höglinger Günter , Houwing-Duistermaat Jeanine 
Published: January 2024

Data integration methods are used to obtain a unified summary of multiple datasets. For multi-modal data, we propose a computational workflow to jointly analyze datasets from cell lines. The workflow comprises a novel probabilistic data integration method, named POPLS-DA, for multi-omics data.
The workflow is motivated by a study on synucleinopathies where transcriptomics, proteomics, and drug screening data are measured in affected LUHMES cell lines and controls. The aim is to highlight potentially druggable pathways and genes involved in synucleinopathies. First, POPLS-DA is used to prioritize genes and proteins that best distinguish cases and controls. For these genes, an integrated interaction network is constructed where the drug screen data is incorporated to highlight druggable genes and pathways in the network. Finally, functional enrichment analyses are performed to identify clusters of synaptic and lysosome-related genes and proteins targeted by the protective drugs. POPLS-DA is compared to other single- and multi-omics approaches.
We found that HSPA5, a member of the heat shock protein 70 family, was one of the most targeted genes by the validated drugs, in particular by AT1-blockers. HSPA5 and AT1-blockers have been previously linked to α-synuclein pathology and Parkinson’s disease, showing the relevance of our findings.
Our computational workflow identified new directions for therapeutic targets for synucleinopathies. POPLS-DA provided a larger interpretable gene set than other single- and multi-omic approaches. An implementation based on R and markdown is freely available online.
Ethical considerations related to drone use for environment and health research: A scoping review protocol
Authors: Hoek Spaans Remy , Drumond Bruna , van Daalen Kim Robin , Rorato Vitor Ana Claudia , Derbyshire Alison , Da Silva Adriano , Lana Raquel Martins , Vega Mauricio Santos , Carrasco-Escobar Gabriel , Sobral Escada Maria Isabel , Codeço Claudia , Lowe Rachel 
Published: January 2024

Introduction
The use of drones in environment and health research is a relatively new phenomenon. A principal research activity drones are used for is environmental monitoring, which can raise concerns in local communities. Existing ethical guidance for researchers is often not specific to drone technology and practices vary between research settings. Therefore, this scoping review aims to gather the evidence available on ethical considerations surrounding drone use as perceived by local communities, ethical considerations reported on by researchers implementing drone research, and published ethical guidance related to drone deployment.

Methods and analysis
This scoping review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) and the Joanna Briggs Institute (JBI) guidelines. The literature search will be conducted using academic databases and grey literature sources. After pilot testing the inclusion criteria and data extraction tool, two researchers will double-screen and then chart available evidence independently. A content analysis will be carried out to identify patterns of categories or terms used to describe ethical considerations related to drone usage for environmental monitoring in the literature using the R Package RQDA. Discrepancies in any phase of the project will be solved through consensus between the two reviewers. If consensus cannot be reached, a third arbitrator will be consulted.

Ethics and dissemination
Ethical approval is not required; only secondary data will be used. This protocol is registered on the Open Science Framework (osf.io/a78et). The results will be disseminated through publication in a scientific journal and will be used to inform drone field campaigns in the Wellcome Trust funded HARMONIZE project. HARMONIZE aims to develop cost-effective and reproducible digital infrastructure for stakeholders in climate change hotspots in Latin America & the Caribbean and will use drone technology to collect data on fine scale landscape changes.
Longitudinal brain structure changes in Parkinson’s disease: A replication study
Authors: Sokołowski Andrzej , Bhagwat Nikhil , Chatelain Yohan , Dugré Mathieu , Hanganu Alexandru , Monchi Oury , McPherson Brent , Wang Michelle , Poline Jean-Baptiste , Sharp Madeleine , Glatard Tristan 
Published: January 2024

Context
An existing major challenge in Parkinson’s disease (PD) research is the identification of biomarkers of disease progression. While magnetic resonance imaging is a potential source of PD biomarkers, none of the magnetic resonance imaging measures of PD are robust enough to warrant their adoption in clinical research. This study is part of a project that aims to replicate 11 PD studies reviewed in a recent survey (JAMA neurology, 78(10) 2021) to investigate the robustness of PD neuroimaging findings to data and analytical variations.

Objective
This study attempts to replicate the results in Hanganu et al. (Brain, 137(4) 2014) using data from the Parkinson’s Progression Markers Initiative (PPMI).

Methods
Using 25 PD subjects and 18 healthy controls, we analyzed the rate of change of cortical thickness and of the volume of subcortical structures, and we measured the relationship between structural changes and cognitive decline. We compared our findings to the results in the original study.

Results
(1) Similarly to the original study, PD patients with mild cognitive impairment (MCI) exhibited increased cortical thinning over time compared to patients without MCI in the right middle temporal gyrus, insula, and precuneus. (2) The rate of cortical thinning in the left inferior temporal and precentral gyri in PD patients correlated with the change in cognitive performance. (3) There were no group differences in the change of subcortical volumes. (4) We did not find a relationship between the change in subcortical volumes and the change in cognitive performance.

Conclusion
Despite important differences in the dataset used in this replication study, and despite differences in sample size, we were able to partially replicate the original results. We produced a publicly available reproducible notebook allowing researchers to further investigate the reproducibility of the results in Hanganu et al. (2014) when more data is added to PPMI.