bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pro-inflammatory Cytokines may Associate Periodontitis with Pregnancy
Complications: A Short Review
Authors: Makiya Ali , Amiri Moghaddam Masoud , Faghihinia Farbod , Mahmoudi Anzabi Reza , Asadi Haniyeh , Fathi Amirhossein 
Published: December 2023

Abstract:
Periodontitis is an oral inflammatory disease possessing detrimental impacts on supporting tissue of teeth (like gingiva, periodontal ligament, and
alveolar bone) and involves a great number of individuals all over the world. One of the appropriate ways to prevent this disease is to find related
risk factors. According to reports, pregnancy complications can be associated with this oral disease; however, the possible mechanisms linking
these two conditions have not been exactly determined. Hence, in this review, we summarize documents related to pregnancy complications and
periodontitis with a mechanistic insight.

:
Literature on the relevant topic was searched from scientific databases, including Scopus, Google Scholar, and PubMed, in English, between 1996
and 2022.

:
3Based on reports, pregnancy complications (premature labor, low weight at birth, and preeclampsia) can be related to periodontitis. This linkage
can be mediated by inflammatory reactions, one of the main pathogenic mechanisms in periodontitis. Pro-inflammatory cytokines, such as TNF-α,
IL-1β, and IL-6, have the ability to induce labor and fetal toxicity and finally create preterm labor and low weight at birth. Besides, these cytokines
can potentiate chronic inflammatory responses in the fetal-maternal interface, impair placentation, and create endothelial dysfunction.

:
It seems that pro-inflammatory reactions, like secretion of TNF-α, IL-1β, and IL-6, can be a bridge for associating periodontitis and pregnancy
complications. However, more studies with larger sample sizes are needed to support these findings.
Potential Antihypertensive Activity of the Aqueous Extract of Ammi visnaga
and its Effect on ACE-2 in Rats
Authors: Amtaghri Smail , Qabouche Adil , Slaoui Miloudia , Eddouks Mohamed 
Published: December 2023

Aims:
This work aimed to investigate the antihypertensive activity of Ammi visnaga.

Background:
The aqueous extract of Ammi visnaga has traditionally been used to treat hypertension
in Morocco.

Objective:
The objective of this investigation was to evaluate the effect of Ammi visnaga aqueous
extract (AVAE) on arterial blood pressure, systolic blood pressure (SBP), mean blood pressure
(MBP), diastolic blood pressure (DBP), and heart rate (HR) in normotensive and hypertensive
rats. In addition, the effect of the aqueous extract of Ammi visnaga on vasodilatation was
assessed in isolated rat aortic rings with functional endothelium pre-contracted with epinephrine
EP or KCl.

Methods:
AVAE was obtained, and its antihypertensive ability was pharmacologically investigated
in L-NAME hypertensive and normotensive rats. The rats received oral AVAE at two selected
doses of 70 and 140 mg/kg for six hours (acute experiment) and seven days (sub-chronic).
Thereafter, systolic, diastolic, mean arterial blood pressure and heart rate were evaluated. Moreover,
the vasorelaxant activity of AESA was performed in thoracic aortic ring rats. In addition,
the mechanisms of action involved in the vasorelaxant effect were studied.

Results:
AVAE lowered blood pressure only in L-Name-induced hypertensive rats. Furthermore,
AVAE (0.375-1.375 mg/ml) showed a vasodilator effect in isolated aortic rats. In addition, not
all of the medications used in our study were responsible for the signaling pathway. As a result,
additional pharmaceuticals are required to confirm the mechanism of this signaling pathway.

Conclusion:
The aqueous extract of Ammi visnaga exerts an interesting antihypertensive activity,
which could be mediated through its vasorelaxant activity. The study supports its use as a
medicinal plant against hypertension in Morocco.
Exploring the Therapeutic Potential: Antiplatelet and Antioxidant
Activities of Some Medicinal Plants in Morocco
Authors: Lafdil Fatima Zahra , Amirou Asmae , Bnouham Mohamed , Legssyer Abdelkhaleq , Ziyyat Abderrahim , Mekhfi Hassane 
Published: December 2023

Background::
Thrombotic events and oxidative stress are major complications of certain
ischemic disorders. The fight against these complications requires very intense research to develop
new therapeutic agents of natural origin.

Objective::
The general objective of this work is the scientific valorization of five medicinal plants:
Rhus pentaphylla, Zizyphus lotus, Ammodaucus leucotrichus, Inula viscosa, and Cinnamomum
zeylanicum by exploring their effects on rat platelet aggregation, antioxidant potential and determining
their phytochemical composition.

Methodology::
The aggregation test was monitored by stimulating isolated washed platelets suspension
in the absence and presence of extracts. The antioxidant activity was conducted in vitro according
to three methods: DPPH free radical scavenging activity, β-carotene bleaching test, and ferric
reducing antioxidant power test. The quantitative determination of total polyphenols and flavonoids
are determined respectively according to the Folin-Ciocalteu method and the colorimetric method
with aluminum chloride.

Results::
The results obtained show that the aqueous extract of the fruits of Rhus pentaphylla and
the aerial part of Inula viscosa, as well as the stalk peel of Cinnamomum zeylanicum, significantly
(p˂0.001) inhibit thrombin-platelet aggregation, while the other plant extracts have a slightly, but
significant effect. These extracts exert a remarkable antioxidant activity with the three methods
used. But, their IC50 values are still higher than those of the antioxidant references (ascorbic acid
and butyl hydroxyanisole). Qualitative phytochemical analysis revealed the presence of secondary
metabolites with varying contents. Additionally, the results of quantitative phytochemical analysis
showed that the aqueous extracts of the leaves of Rhus pentaphylla and the aerial part of Inula viscosa
contain the highest amount of polyphenols and flavonoids. These secondary metabolites are
also present in the other extracts but in smaller quantities.

Conclusion::
These results could contribute to the validation of the medical use of these extracts that
exert an antiplatelet effect to treat hemostatic and thrombotic disorders.
Mathematical Model of an Automated System for Learning to Play the Piano
Authors: Ostrenko A. A. , Ryzhkova M. N. 
Published: December 2023

Purpose of research. Nowadays, the automation of the distance learning process or self-study is relevant. However, to increase its effectiveness, there is a need for a personality-oriented approach to the student. The creation of adaptive learning technologies is becoming a priority. Development of a mathematical model of an automated system for learning to play the piano was the purpose of this work.Methods. The article discusses one of the approaches to modeling educational processes and systems - the cybernetic approach. The use of this approach allows us to consider the model of the educational system from the point of view of internal blocks and their functions, it allows us to identify sets of input and output data and internal relationships of various components of the system. The mathematical model is based on the operations of the algebra of logic and set theory.Resalts. Based on the cybernetic approach, the article provides a functional diagram of the system, which clearly demonstrates the sequence of actions performed, as well as the flow of various sets of input and output data. The functionality of the blocks is described in the terminology of operators, which determine the sequence and the required number of questionnaire questions to determine the initial knowledge, skills, and abilities of the trainee and his goals, select the most optimal initial training plan, assess progress and adjust the initial training plan depending on the results of the student. For each operator, sets of inputs and outputs are defined. The description of the data shows what information the system must operate in order for it to work correctly and efficiently. Another significant result of the work was the mathematical model of the system obtained as a result of research, which determines the relationship between input and output data.Conclusion. The cybernetic approach to modeling educational activities, including in the system of additional education, allows you to structure complex logical connections in the educational system, to determine the sequence and options for the system. The model will form the basis of the information system for piano playing teaching.
Digital Recording Computer System with the Function of Recording Measurement Data to SDHC Memory Card
Authors: Martyshkin A. I. , Danilov E. A. 
Published: December 2023

Purpose of research. The main idea of the article is to develop a digital device created on domestic components and designed to record measurement information with the function of recording on a memory card and transferring it to a personal computer using a USB-interface. The article also considers the tasks to be solved.Methods. Having analyzed possible alternative variants of development of the registering computer system, the authors offer a variant of its realization on the microcontroller, in the software of which it is necessary to provide the following functions: realization of information exchange via RS-485 interface; realization of exchange via USB 2.0 interface for transfer of the accumulated registered information to the computer; realization of recording, reading and erasing of the registered information on the flash-drive; realization of the counter of its own time with uninterrupted work at the time of the registration of the information on the microcontroller.Results. This paper develops a digital device designed for digital registration with the function of recording measurement information on an SDHC memory card. The operation of the device consists in providing registration of information with saving it in the form of files on a memory card of SDHC format. Access to the registered information is made from a computer via USB 2.0 interface in the memory device mode by means of a software driver realized in the microcontroller 1986BE92T of the Milandr company. Initialization of the device is carried out with the help of a computer, through the driver implementing hardware bridge USB-UART on the standard USB 2.0.Conclusion. The obtained results satisfy the set goal and objectives. A textual description of the microcontroller firmware in C language is developed. In addition, the paper develops application software designed to obtain measurement results and send control commands to the microcontroller. The field of application of the proposed device is specialized computing systems designed for digital recording of information.
Algorithm for Creating 3d Scenes of Recognized Objects from Depth Maps
Authors: Bobyr M. V. , Emelyanov S. G. , Milostnaya N. A. 
Published: December 2023

Purpose of research.Development of an algorithm for constructing 3d scenes of recognized objects from synthesized depth maps in order to improve the speed of real-time image processing.Methods.The 3d scene construction algorithm is based on the method of stereo image construction using a threelevel fuzzy depth map construction model. At the first level of this model the boundaries of objects are determined using a modified Canny algorithm, at the second level the values of disparity are calculated on the basis of the sum of absolute differences algorithm modified by fuzzy logic methods, and at the final level the gradients of distances from the boundaries of images to the edges of recognized objects are calculated first and then according to the obtained values of disparity at the second and third levels of the fuzzy hierarchical model, the refined values of disparity are calculated, which are used to carry out the analysis of the depth map.Results.An algorithm for constructing 3d scenes of recognized objects using synthesized depth maps has been developed. It was determined that the proposed algorithm has better performance compared to existing depth map algorithms such as conjugate point algorithm and pyramidal algorithm.Conclusion.The experimental results showed that the proposed algorithm has a lower complexity compared to the analyzed algorithms (conjugate points and pyramidal). The minimum average execution time of the 3d scene construction operation was about 1-2 minutes, which is almost 120 times better compared to the conjugate point algorithms.
ANTI-ALOPECIA ACTIVITY OF MORINGA (MORINGA OLEIFERA LAMK.) SEED OIL AGAINST DIHYDROTESTOSTERONE-INDUCED RABBITS
Authors: KORASSA YULIUS BAKI , SAPTARINI NYI MEKAR , MUSTARICHIE RESMI , HENDRIANI RINI , OLA ANTONIUS R. B. , NOVICADLITHA YOAN , KAPITAN LELY A V 
Published: December 2023

Objective: Alopecia is a condition where there is hair loss or no growth of hair, which can occur as a result of stress, heredity, hormonal factors or due to certain diseases such as diabetes mellitus. This study aimed to determine the anti-alopecia activity of moringa seed oil against rabbits induced by dihydrotestosterone (DHT).
Methods: The methods used was the alopecia rabbit model according to Matias with moringa seed oil concentrations of 7.5, 10 and 12.5%, positive control (0.1% finasteride) and negative control (1% tween 80) with parameters hair length and hair weight test.
Results: Results showed that moringa seed oil concentrations of 7.5, 10 and 12.5% had anti-alopecia activity with average hair length of 3.4±0.17, 3.9±0.20 and 4.5±0.28 cm, respectively and average hair weight of 118±23.148±30.9 and 175±47.2 mg respectively.
Conclusion: Moringa seed oil concentration of 12.5% had optimal activity for developing as anti-alopecia based on the statistical analysis value of hair length (125x10-3>0.05) was not significantly different while hair weight (3x10-3<0.05) was significantly different from the positive control of 0.1% finasteride.
ANTI-ACNE CREAM OF LEAVES EXTRACT OF FIG (FICUS CARICA L.) FROM CIWIDEY DISTRICT, INDONESIA, AGAINST PROPIONIBACTERIUM ACNES AND STAPHYLOCOCCUS EPIDERMIDIS
Authors: SAPTARINI NYI MEKAR , AULIFA DIAH LIA , MUSTARICHIE RESMI , HENDRIANI RINI , HERAWATI IRMA ERIKA , CORPUZ MARY JHO-ANNE T. 
Published: December 2023

Objective: This study aimed to formulate and evaluate an anti-acne cream of fig leaves extract.
Methods: The methods included formulation and evaluation of anti-acne cream, antibacterial activity assay against Propionibacterium acnes and Staphylococcus epidermidis, irritancy test, and preference test. The oil-in-water creams were made with various extract concentrations (1, 2, and 3%).
Results: Greenish cream with fig fragrant, viscosity ranging from 332 to 388 cP, pH ranging from 6.69 to 7.23, and oil-in-water type. Antibacterial activity was dose-dependent, without irritancy, erythema, and edema, and the most preferred cream based on the texture and fragrance was the 3% extract formula.
Conclusion: Fig leaves extract can be made into a safe cream with antibacterial activity against P. acnes and S. epidermidis.
IN SILICO IDENTIFICATION OF NATURAL PRODUCTS WITH ANTITUBERCULOSIS ACTIVITY FOR THE INHIBITION OF INHA AND ETHR PROTEINS FROM MYCOBACTERIUM TUBERCULOSIS
Authors: RAMDHANI DANNI , KUSUMA SRI AGUNG FITRI 
Published: December 2023

Objective: The rise of Mycobacterium tuberculosis (MT) strains that are resistant to antibiotics poses a serious threat to public health, particularly in middle and low-income countries. The important role of natural products (NPs) in the discovery of new drugs to treat infectious diseases is driving the success of synthetic chemistry in the production of new drugs. In our study, 15 NPs were selected to be investigated for their anti-TB properties by in silico method.
Methods: Molecular reverse docking approach to predict the interaction of NPs as a drug lead against the regulatory proteins (InhA, EthR) of MT. For each mycobacterial target, the docking scores/binding free energies were predicted and calculated using AutoDock Vina along with the physicochemical and structural characteristics of the NPs, and they were compared to the established inhibitor (control) drugs.
Results: The specific interactions of luteolin, piperine, butein, tiliacorinine against the targets InhA and EthA (-9.1 and-6.7 kcal. mol-1;-9.1 and-8.4 kcal. mol-1;-8.4 and-6.6 kcal. mol-1;-8.3 and-7.6 kcal. mol-1) had significantly superior docking scores compared to controls.
Conclusion: Our research proposed these compounds as potent therapeutic agents for the development of anti-tuberculosis medications; however, additional in vitro and in vivo testing is required to confirm their potential as novel therapeutics and mechanisms of action.
Persebaran, Aksesibilitas, dan Arah Lokasi Rumah Sakit Bersalin Di Kota Blitar
Authors: Nurul Hidayah  , Novi Andareswari  , Mira Setiawati Abdullah  , Firman Afrianto  
Published: December 2023

Background: Tindakan mengurangi ketidaksiapan dalam melakukan pertolongan pada ibu dan anak saat melahirkan diperlukan untuk menurunkan angka kematian ibu dan anak di Kota Blitar. Salah satu tindakannya adalah memberikan arahan lokasi fasilitas kesehatan terdekat. Penentuan lokasi terdekat ini membutuhkan analisis jumlah persebaran, aksesibilitas dan lokasi Rumah Sakit Bersalin.Tujuan dari penelitian ini untuk mengetahui arahan lokasi Rumah Sakit Bersalin terdekat yang dapat dijangkau masing-masing Kelurahan di Kota Blitar. Metode: Metode yang digunakan adalah analisis secara spasial dengan menggunakan data geografis dan GIS (Geographic Information System). Data yang digunakan berupa titik koordinat lokasi Sarana Kesehatan Rumah Sakit Bersalin yang ada di Kota Blita. Hasil: Dari hasil analisis beberapa arahan untuk Rumah Sakit Bersalin yang dapat dikunjungi di saat darurat dengan lokasi paling dekat dengan daerah di Kota Blitar adalah RS Islam Aminah Blitar, RS Siti Khadijah, Rumah Sakit Umum Aminah Blitar, Rumah Sakit Syuhada Haji, RSK Budi Rahayu, Rumah Bersalin Bidan Sitti, dan Dr. I Wayan Rupana, Sp.OG. Kesimpulan: Hampir seluruh wilayah di Kota Blitar terjangkau oleh Sarana Kesehatan Rumah Sakit Bersalin ataupun sarana kesehatan untuk persalinan lainnya dengan jarak dan waktu tempuh yang berbeda-beda dari masing-masing wilayah. Sarana Kesehatan Rumah Sakit Bersalin berpusat di Kelurahan Kepanjen Lor.
Do all prostate cancer patients want, and experience shared decision making prior to curative treatment?
Authors: Otrebski Nilsson Mona , Aas Kirsti , Myklebust Tor Å. , Gjelsvik Ylva Maria , Haug Erik Skaaheim , Fosså Sophie D. , Johannesen Tom Børge 
Published: December 2023

Objective: In comparable men with non-metastatic prostate cancer, radical prostatectomy (RP), radiotherapy (RAD) and active surveillance (AS) are treatment options with similar survival rates, but different side-effects. Healthcare professionals consider pretreatment shared decision making (SDM) to be an essential part of medical care, though the patients’ view about SDM is less known. In this article, we explore prostate cancer (PCa) patients’ SDM wish (SDMwish), and experiences (SDMexp).
Material and methods: This is a registry-based survey performed by the Cancer Registry of Norway (2017–2019). One year after diagnosis, 5,063 curatively treated PCa patients responded to questions about their pre-treatment wish and experience regarding SDM. Multivariable analyses identified factors associated with SDM. Statistical significance level: p < 0.05.
Results: Overall, 78% of the patients wished to be involved in SDM and 83% of these had experienced SDM. SDMwish and SDMexp was significantly associated with decreasing age, increasing education, and living with a partner. Compared with the RP group, the probability of SDMwish and SDMexp was reduced by about 40% in the RAD and the AS groups.
Conclusion: Three of four curatively treated PCa wanted to participate in SDM, and this wish was met in four of five men. Younger PCa patients with higher education in a relationship, and opting for RP, wanted an active role in SDM, and experienced being involved. Effective SDM requires the responsible physicians’ attention to the individual patients’ characteristics and needs.
O Instituto Nacional de Pesquisas da Amazônia (INPA) e o seu papel na popularização da Ciência em Manaus
Authors: Seiffert Santos Saulo Cezar , Cunha Márcia Borin da 
Published: December 2023

ResumoA formação científica de uma população pode ocorrer em diferentes espaços, sendo alguns relacionados à pesquisa científica de uma região. Todavia, a presença de instituições científicas não é condição fundamental para ocorrer popularização da Ciência, mas é algo que acontece no Instituto Nacional de Pesquisas da Amazônia, INPA. Neste artigo, temos como objetivo associar parte da história da cidade de Manaus com a atividade científica e sua popularização promovidas pelo INPA. Este estudo foi realizado por meio de uma pesquisa bibliográfica, visitas no local e anotações, que deram origem a três argumentos: a) instituições científicas promovem popularização da Ciência; b) parte da popularização da Ciência se dá por meio das exposições científicas; c) as exposições científicas fazem parte de uma educação não formal, que se relacionam ao ethos da instituição. Apresentamos a história das instituições de pesquisa em Manaus/AM, algumas falências e aquelas que prosperaram, e como exemplo, destacamos alguns resultados de divulgação científica exitosa - o Bosque da Ciência do INPA.Palavras-chave: popularização científica; instituições de pesquisa; Manaus; Amazônia.AbstractThe scientific formation of a population can occurs in different spaces, some of which are related to scientific research in a region. However, the presence of scientific institutions is not a fundamental condition for the popularization of Science, but it is something that happens at the National Institute of Amazonian Research, NIAR. In this article we aim to associate part of the history of the city of Manaus with the scientific activity and its popularization promoted by NIAR. This study was carried out through bibliographic research, on-site visits and notes, which gave rise to three arguments: a) scientific institutions promote the popularization of science; b) part of the popularization of science occurs through scientific exhibitions; c) scientific exhibitions are part of a non-formal education, which are related to the institution's ethos. We present the history of research institutions in Manaus AM, some bankruptcies and those that prospered, as an example, we present some results of successful scientific dissemination - the Science Forest of NIAR.Keywords: scientific popularization; research institutions; Manaus; Amazon.
A PEDAGOGIA DA ESCRITA E OS DESAFIOS NA SOCIEDADE CONTEMPORÂNEA
Authors: Caputo Fabiana Bugan , Nogueira Joani Almeida dos Santos , Gavioli Wellerson Clemer dos Santos 
Published: December 2023

Para os ensinantes-aprendentes de Língua Portuguesa, um dos desafios mais debatidos está relacionado ao ensinar os aprendentes-ensinantes a serem escritores competentes. São inúmeras as pesquisas voltadas a responder tal questionamento. Uma das propostas vem da Educação Linguística que tem se mostrado como área de estudo que visa ao pleno desenvolvimento do educando como profundo conhecedor de sua própria língua e, por meio dela, ser protagonista e autônomo, a fim de exercer seu direito de cidadão. Desse modo, o presente artigo visa a discutir a respeito da Pedagogia da escrita, bem como sua aquisição e os desafios dos ensinantes-aprendentes de Língua Portuguesa ao ensinarem seus aprendentes-ensinantes a escreverem diferentes textos, considerando o gênero como ponto de partida, o contexto de produção e a linguagem empregada