bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutronic and thermal-hydraulic assessment of the TRR with new core designed based on tubular fuels
Authors: Gharari Rahman , Khoshahval Farrokh , Hasanzadeh Mostafa , Mozaffari M. Amin , Amirkhani M. Amin , Esmaili Hasan 
Published: November 2023

Abstract
Herein, the feasibility study of the Tehran Research Reactor (TRR) with a new core designed based on tubular fuels from the neutronic, thermal-hydraulic, safety, and operational points of are investigated using MCNPX, WIMS, CITATION, Computational Fluid Dynamics (CFD), and RELAP codes. According to the results, the total neutron flux in the new core with tubular fuels is increased by more than 14.3 % compared with the current core of the TRR with plate-type fuels. Moreover, due to the higher fuel amount in the tubular compared with plate-type fuels (about 17 % in similar conditions), its effective multiplication factor is much higher than the TRR with plate-type fuels. Moreover, the results show that the maximum cladding temperature is sufficiently lower than 105 °C and the produced heat in the tubular fuel are removed without changing the current flow rate of the core. Furthermore, the maximum fuel temperature in tubular fuel is about 10 °C lower than the maximum fuel temperature in the current standard fuel element.
Green creation of CoFe2O4 nanosorbent for superior toxic Cd ions elimination
Authors: Alqarni Laila S. 
Published: November 2023

Abstract
A mesoporous cobalt ferrite nanostructure was prepared by a green chemistry approach using Pimpinella anisum extract for Cd (II) ions elimination from an aqueous medium. The metal ions adsorption was explored under varying operating conditions, comprising of the pH, initial adsorbate concentration, and contact time. The synthesized sorbent was characterized by various techniques where the XRD data verified a ferrite structure of ≈25 nm crystallite size and the EDX elemental analysis affirmed the presence of the corresponding elements. The CoFe2O4 established porosity characteristic of 10.8 m2 g−1 BET-specific surface area and 0.023 cm3 g−1 pore volume values. Batch mode experiments ascertained that the Cd (II) ions uptake was pH-dependent, with peak removal of 170 mg/g accomplished at pH = 5. The adsorption process of the metal ions onto the mesoporous nanomaterial surface fitted well with the Langmuir isotherm and pseudo-second-order kinetics models. The mechanistic aspects indicated the role of intra-particle and film diffusion in the adsorption process. The adsorbent could efficiently remove the pollutant up 74.3 % to four cycles of successful regeneration. This investigation endorsed that CoFe2O4 might be potent candidate for heavy metals from aqueous systems.
Does the Number of Comorbidities Predict Pain and Disability in Older Adults With Chronic Low Back Pain? A Longitudinal Study With 6- and 12-Month Follow-ups
Authors: Lemes Ítalo R. , Morelhão Priscila K. , Verhagen Arianne , Gobbi Cynthia , Oliveira Crystian B. , Silva Nayara S. , Lustosa Lygia P. , Franco Márcia R. , Pinto Rafael Z. 
Published: November 2023

Background and Purpose:
People who live longer often live with multimorbidity. Nevertheless, whether the presence of multimorbidity affects pain and disability in older adults with chronic low back pain (LBP) remains unclear. The aim of this study was to investigate whether multimorbidity predicts pain intensity and disability at 6- and 12-month follow-ups in older adults with chronic LBP.

Methods:
This was a prospective, longitudinal study with 6- and 12-month follow-ups. Participants with chronic LBP (age ≥ 60 years) were recruited and interviewed at baseline, 6 months, and 12 months. Self-reported measures included the number of comorbidities, assessed through the Self-Administered Comorbidity Questionnaire, pain intensity, assessed with the 11-point Numerical Rating Scale, and disability, assessed with the Roland-Morris Disability Questionnaire. Data were analyzed using univariate and multivariate regression models.

Results and Discussion:
A total of 220 participants were included. The number of comorbidities predicted pain intensity at 6-month (β= 0.31 [95% CI: 0.12 to 0.50]) and 12-month (β= 0.29 [95% CI: 0.08 to 0.50]) follow-ups. The number of comorbidities predicted disability at 6-month (β= 0.55 [95% CI: 0.20 to 0.90]) and 12-month (β= 0.40 [95% CI: 0.03 to 0.77]) follow-ups.

Conclusion:
The number of comorbidities at baseline predicted pain and disability at 6-month and 12-month follow-ups in older adults with chronic LBP. These results highlight the role of comorbidities as a predictive factor of pain and disability in patients with chronic LBP, emphasizing the need for timely and continuous interventions in older adults with multimorbidity to mitigate LBP-related pain and disability.
Relationship Between Cognitive Functions and Agility Performance in Elite Young Male Soccer Players
Authors: Matlák János , Fridvalszki Marcell , Kóródi Viktor , Szamosszegi Gábor , Pólyán Edina , Kovács Bálint , Kolozs Barbara , Langmár Gergely , Rácz Levente 
Published: November 2023

Abstract
Matlák, J, Fridvalszki, M, Kóródi, V, Szamosszegi, G, Pólyán, E, Kovács, B, Kolozs, B, Langmár, G, and Rácz, L. Relationship between cognitive functions and agility performance in elite, young, male soccer players. J Strength Cond Res XX(X): 000–000, 2023—The aim of this study was to assess the relationship between agility performance and cognitive functions measured under laboratory conditions among elite young soccer players. Twenty-five, elite, young, male soccer players (12.3 ± 0.4 years, 155.4 ± 7.6 cm, 42.6 ± 6.9 kg) completed a battery of field tests, including 5-, 10-, 20-m sprints, change of direction speed (CODS), standing long jump, and an agility test based on a human stimulus. Subjects also completed choice reaction (RT, S3) and reactive stress tolerance (DT, S1) tests on the Vienna Test System. There was a moderate significant relationship (p < 0.05) found between mean reaction time and mean motor time during the choice reaction task and decision time in the agility test. Decision time also showed a large significant correlation (p < 0.05) with total time in the agility test. No significant correlation was found between total time in the agility test and variables measured during RT and DT tests. No significant correlations were found between agility test results and results from straight line sprints, CODS, and standing long jump tests. The results of this study suggest that choice reaction time is related to decision-making speed during the agility task used in this study and can have an indirect effect on agility performance in elite young soccer players. Further studies assessing the relationship between different cognitive functions and agility performance in different sports and age categories could help in the identification of determinant cognitive functions in perceptual and decision-making factors of agility.
Inventario del patrimonio arquitectónico, Bucaramanga, Santander, Colombia
Authors: Rivas Carrero María Angélica , Cano Valencia Juan Alejandro 
Published: November 2023

El Centro Histórico de la ciudad de Bucaramanga, Santander, Colombia se ha configurado en un contexto cargado de objetos y de hitos referenciales con reminiscencias coloniales, neoclásicas y moderna que constituyen en conjunto datos espaciales representativos de nuestra cultura. Encontramos edificaciones que han sido declaradas Bienes de Interés Cultural (BIC) del Grupo Arquitectónico tanto en el ámbito nacional, departamental y municipal, y que forman parte del listado del municipio. Identificar e inventariar los Bienes de Interés Cultural nos acerca a la reflexión y a la apropiación de la cultura local en la generación de conciencia, participación, compromiso e identidad como una forma de recuperar la memoria de la ciudad. En la investigación se utilizó la metodología documental a partir de la revisión de fuentes documentales, bibliográficas y hemerográficas, por otro lado, se planteó un trabajo de campo que no fue viable debido a la pandemia del COVID-19. La información recopilada y analizada se utilizó para crear un inventario de Bienes de Interés Cultural, cumpliendo con los estándares establecidos por el Ministerio de Cultura de Colombia (MinCultura), lo que contribuirá a la preservación y promoción del patrimonio cultural de Bucaramanga y su identidad histórica y cultural.
ATXN3 promotes proliferation, stemness and motility of clear cell renal cell carcinoma cells by regulating S100A8 ubiquitination
Authors: Bai Jixiang , Han Jieru , Fan Jiayi , Song Jing , Wang Shuhui 
Published: November 2023

AbstractBackgroundClear cell renal cell carcinoma (ccRCC) is a dominant subtype of kidney cancer with a dismal outcome at advanced stages. Ataxin 3 (ATXN3) has been proven to play a cancer-promoting role in several tumors and is upregulated in the patients with renal cell carcinoma. Thus, the objective of this research is to examine the biological roles and underlying mechanisms of ATXN3 in ccRCC.MethodsBioinformatics analysis was carried out to analyze ATXN3 expression in ccRCC tissues and patient survival. Gain- and loss-of-function assays were applied to explore the effect of ATXN3 on ccRCC cell malignant behavior in vitro. The effect of ATXN3 on the NF-κB pathway was assessed by Western blot and immunofluorescence staining. The binding between ATXN3 and S100A8 and the effect of ATXN3 on S100A8 ubiquitination were verified using coimmunoprecipitation.ResultsATXN3 was upregulated in ccRCC tissues and correlated with adverse patient outcome. ATXN3 overexpression facilitated the proliferation, stemness, invasion and migratory capacity of ccRCC cells, whereas silencing had the opposite effect. ATXN3 enhanced the activity of the NF-κB pathway. Silencing ATXN3 facilitated S100A8 ubiquitination. Rescue experiments demonstrated that S100A8 downregulation reversed the promoting effect of ATXN3 on malignant behavior and NF-κB pathway activation in ccRCC cells.ConclusionATXN3 exerts a cancer-promoting effect in ccRCC by regulating S100A8 ubiquitination. Therefore, targeting the ATXN3/S100A8/NF-κB axis may provide a novel underlying therapeutic strategy for ccRCC.
Thyroid Profile and Serum Lipid Level in Women with Normal Pregnancy
Authors: Kumar Raj , Kumar Sudeep , Arora Manisha , Kumar Dinesh , Sah Sumesh Prasad , Sharma Shivani 
Published: November 2023

Objective: To evaluate the changes in thyroid profile and serum lipid level in normal pregnancy.Methods: This observational study was conducted at the Department of Biochemistry of Santosh Medical College, Ghaziabad, UP, India, from June 2021 to February 2022. In this study, 200 average pregnant women were enrolled. The thyroid profile was estimated using the ELISA method, and the lipid profile was measured using the enzymatic kit method. All data were expressed as means and standard deviations, and SPSS version 17 was used for statistical analysis.Results: This observational study observed that the mean T3, T4, and TSH levels increased significantly in the second trimester compared to the first trimester. In contrast, the mean value of T3, T4, and TSH decreased in the third trimester as compared to the second trimester. The mean levels of total cholesterol, triglyceride, and LDL-cholesterol increased significantly, while the mean value of HDL-cholesterol decreased significantly in the second and third trimesters when compared to the first trimester.Conclusion: This study demonstrated abnormal lipid and thyroid metabolism. Changes in thyroid profile may be associated with adverse obstetric outcomes. The altered lipid parameters, mainly High TG and low HDL-C concentrations, may promote vascular dysfunction and oxidative stress.
Conservative Management of Pott's Spine and Its Outcome: An Institute-Based Observational Study
Authors: Jiwani Rahil , Ghosh Sourabh , Giri Shubham 
Published: November 2023

Objective: To analyze the functional outcome of cases with Pott’s disease treated solely by antitubercular drugs.Methods: This observational study was conducted at the Department of Orthopedics of a tertiary care medical college. Sixty patients with Pott’s disease were included in this study based on predefined inclusion and exclusion criteria. All patients received antitubercular drugs for nine months. The Modified McCormick Scale (MSS) was used to assess the outcome of patients.Results: Out of 60 patients, 37 (61.67%) were females, and 23 (38.33%) were males, with an M: F ratio of 1:0.62. Most patients had some or the other risk factors and belonged to low socioeconomic status. The most common presenting complaint was low back pain, and the thoracolumbar spine was most commonly involved. There was a significant improvement in the patient’s functional status as assessed by the MSS score.Conclusion: If diagnosed early, patients with Pott’s disease can be treated solely by antitubercular treatment with excellent outcomes.
Molecular cytological analysis of alien introgressions in common wheat lines created by crossing of <i>Triticum aestivum</i> with <i>T. dicoccoides</i> and <i>T. dicoccum</i>
Authors: Orlovskaya О. A. , Leonova I. N. , Solovey L. A. , Dubovets N. I. 
Published: November 2023

Wild and domesticated emmer (ВВАА, 2n = 28) are of significant interest for expanding the genetic diversity of common wheat as sources of a high protein and microelement grain content, resistance to many biotic and abiotic factors. Particular interest in these species is also determined by their close relationship with Triticum aestivum L., which facilitates interspecific hybridization. The objective of this work was to analyze the nature of alien introgressions in hybrid lines from crossing common wheat varieties with T. dicoccoides and T. dicoccum, and to assess the effect of their genome fragments on the cytological stability of introgression lines. A C-banding technique and genotyping with SNP and SSR markers were used to determine localization and length of introgression fragments. Assessment of cytological stability was carried out on the basis of chromosome behavior in microsporogenesis. A molecular cytogenetic analysis of introgression wheat lines indicated that the inclusion of the genetic material of wild and domesticated emmer was carried out mainly in the form of whole arms or large fragments in the chromosomes of the B genome and less extended inserts in the A genome. At the same time, the highest frequency of introgressions of the emmer genome was observed in chromosomes 1A, 1B, 2B, and 3B. The analysis of the final stage of meiosis showed a high level of cytological stability in the vast majority of introgression wheat lines (meiotic index was 83.0–99.0 %), which ensures the formation of functional gametes in an amount sufficient for successful reproduction. These lines are of interest for the selection of promising material with agronomically valuable traits and their subsequent inclusion in the breeding process.
Powdery mildew resistance of apple clonal rootstocks from the collection of the Michurinsk State Agrarian University
Authors: Shamshin I. N. , Dubrovsky M. L. , Trifonova A. A. , Boris K. V. , Kudryavtsev A. M. 
Published: November 2023

Apple clonal rootstocks are the basis of modern intensive horticulture, providing a rapid increase in yield and convenience of fruit trees cultivation. Production of clonal rootstocks under high humidity often causes powdery mildew infection caused by the pathogenic fungus Podosphaera leucotricha Salm., which significantly reduces the productivity of stoolbed. Growing powdery mildew resistant genotypes is the most appropriate way to combat this disease and allows reducing the use of fungicides. To accelerate the search for resistant forms, molecular markers associated with resistance genes have been developed. However, these markers have not been used to study clonal rootstocks. The aims of the work were the field assessment of powdery mildew resistance of apple clonal rootstocks from the collection of the Michurinsk State Agrarian University and the screening of the collection for Pl-1, Pl-2, Pl-w and Pl-d resistance genes. The results of a three-year field evaluation of powdery mildew resistance of 80 rootstocks allowed us to distinguish five main groups ranging from very low to highly resistant. A group of 57 accessions was classified as powdery mildew resistant. The search for resistance genes was performed using the AT20 SCAR (Pl-1 gene), OPU02 SCAR (Pl- 2 gene), EM DM01 (Pl-d gene), and EM M02 (Pl-w gene) markers. The Pl-d and Pl-1 genes identified in 33 (41.25 %) and 31 (38.75 %) accessions, respectively, were the most common in the collection. The Pl-w gene was detected only in two accessions. Identification of the Pl-2 gene with the OPU02 SCAR marker did not reveal a fragment of the expected size. Thirty accessions with different powdery mildew resistance scores had two genes, Pl-1 and Pl-d, and highly resistant forms G16 and 14-1 had a combination of the Pl-d and Pl-w genes. These accessions can be used as donors of powdery mildew resistance for breeding new apple clonal rootstocks.
Decision Support in Dynamic Traffic Management
Authors: Hoogendoorn Serge P. , De Schutter Bart , Schuurman Henk 
Published: November 2023

To support operators in Regional Traffic Management Centers in their task to efficiently and safely manage traffic flows on the motorway and urban networks, a decision support system is being developed. An essential function of this system is its ability to predict the effects of a large number of candidate control scenarios, given the recurrent and non-recurrent conditions in the network. This article proposes such a prediction system referred to as BSES (Boss Scenario Evaluation System), which can evaluate control scenarios in real time, predicting their effects in terms of various measures of effectiveness, such as total travel times, vehicle loss times, average speeds, fuel consumption, etc. The main characteristics of the system are l) that it is case- based, i.e. it uses either synthetic or real-life examples of the effect of control scenarios under different circumstances; 2) that is determines the similarity of the current situation to different examples in the case-base using fuzzy logic, and 3) that it is agent-based, meaning that it predicts the effects of the different measures for small subnetworks and combines these predictions afterwards. In the article, synthetic data is used to set-up the case base. The test results described in the article illustrate the workings of the system, and shows that the system can provide the operator with real-time predictions. Furthermore, the predictions of the system are in comparable to the predictions from the simulation model used to fill the case-base, showing that the method is applicable to generalize the - in this case synthetic - data it uses.
Tolling Heavy Goods Vehicles on European Roads. From a Diverse Set of Solutions to Interoperability?
Authors: Viegas José 
Published: November 2023

This paper is based on work carried out in the DESIRE research project of the European Commission’s 5th Framework Program, dedicated to the identification of preferred schemes for inter-urban tolling of Heavy Goods Vehicles (HGV’s) in the EU. As such, it presents some of the current developments related to this type of tolling, starting with the relevant transport policy background and a brief review of the various forms of tolling in existence and the main technological approaches used for tolling operations. A variety of situations in different countries studied in the project is then reviewed and presented in a framework that tries to put them in perspective according to several angles, accompanied by some explanation of the choices made in the various countries. A synthesis of this complex set of realities is produced thereafter in the form of a suggestion for a preferred form of pricing scheme. Recognising that various background conditions have led to legitimately different choices, but also that interoperability of each vehicle across regional and national borders is a natural request in international freight transport, the issue of the real value and costs of interoperability is finally discussed. It is argued that political difficulties for approval of these schemes at national level have been so strong that the policy package presented for parliamentary approval generally has to be very well tuned to the prevailing balances of power, thus leaving the issue of interoperability to a later stage. This evolution is currently of a relatively easy conceptual formulation, but many institutional and economic hurdles must be expected along the way. It is expected that interoperability may be reached within some 10 years, when there will be joint pressure for it from the demand side (hauliers) and from the supply side (technology suppliers).
Pricing of Intermodal Transport. Lessons Learned from RECORDIT
Authors: Ricci Andrea 
Published: November 2023

Intermodal transport is defined as a sequence of activities involving modal haulages, transhipments and terminals, and requiring the intervention of a variety of operators, whose roles partially overlap and compete. This entails an inherent complexity of the cost and price formation mechanisms, and an overall lack of transparency resulting both from the technical difficulty to establish a reliable and effective accounting framework, and from the high level of competition currently observed between operators. Specific obstacles to cost valuation and pricing are also related to the choice of the units of measure, whereby intermodal traffic is usually assessed with reference to the Loading Unit concept, rather than in terms of vehicles moved. The RECORDIT project (Real Cost Reduction of Door-to-door Intermodal Transport) is briefly presented, with particular reference to its pricing-relevant objectives: designing an original accounting framework for intermodal transport, and documenting the value of individual cost items (both internal and external) based on the detailed, bottom-up analysis of three intermodal trans-European corridors and their all-road competing alternatives. Intermodal transport is found to be consistently cheaper than all-road solutions, and its external costs significantly lower, thereby confirming the high potential of intermodal transport in increasing the sustainability of the transport sector. Lead times are however substantially longer than for road, which contributes to explain the currently limited market share of intermodal transport services. For price setting purposes, RECORDIT has carried out a comparison between social costs (internal + external) and taxes and charges currently paid. The evidence from the three corridors analysed does not lead to uniform conclusions, owing to a high level of variability of results in relation to corridor-dependent parameters, and thereby confirming the need for a price-setting approach that allows to adequately reflect the specific characteristics of each route. Further research and policy initiatives can be envisaged to facilitate the pricing reform process, particularly directed at reducing information gaps and increasing transparency, also through the establishment of more effective institutional and market mechanisms.