bluuebunny/crossref_metadata_2025_split huggingface dataset:
Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription
Authors: Chen Yu , Zhen Zhengyi , Chen Lingjiang , Wang Hao , Wang Xuhui , Sun Xiaoxiang , Song Zhiwei , Wang Haiyan , Lin Yizi , Zhang Wenjun , Wu Guizhu , Jiang Ying , Mao Zhiyong 
Published: November 2023

AbstractAging is accompanied by a decreased DNA repair capacity, which might contribute to age‐associated functional decline in multiple tissues. Disruption in hormone signaling, associated with reproductive organ dysfunction, is an early event of age‐related tissue degeneration, but whether it impacts DNA repair in nonreproductive organs remains elusive. Using skin fibroblasts derived from healthy donors with a broad age range, we show here that the downregulation of expression of XRCC4, a factor involved in nonhomologous end‐joining (NHEJ) repair, which is the dominant pathway to repair somatic double‐strand breaks, is mediated through transcriptional mechanisms. We show that the androgen receptor (AR), whose expression is also reduced during aging, directly binds to and enhances the activity of the XRCC4 promoter, facilitating XRCC4 transcription and thus stabilizing the genome. We also demonstrate that dihydrotestosterone (DHT), a powerful AR agonist, restores XRCC4 expression and stabilizes the genome in different models of cellular aging. Moreover, DHT treatment reverses senescence‐associated phenotypes, opening a potential avenue to aging interventions in the future.
Trends in Outpatient Influenza Antiviral Use Among Children and Adolescents in the United States
Authors: Antoon James W. , Sarker Jyotirmoy , Abdelaziz Abdullah , Lien Pei-Wen , Williams Derek J. , Lee Todd A. , Grijalva Carlos G. 
Published: November 2023

BACKGROUND
Influenza antivirals improve outcomes in children with duration of symptoms &lt;2 days and those at high risk for influenza complications. Real-world prescribing of influenza antivirals in the pediatric population is unknown.

METHODS
We performed a cross-sectional study of outpatient and emergency department prescription claims in individuals &lt;18 years of age included in the IBM Marketscan Commercial Claims and Encounters Database between July 1, 2010 and June 30, 2019. Influenza antiviral use was defined as any dispensing of oseltamivir, baloxavir, or zanamivir. The primary outcome was the rate of antiviral dispensing per 1000 enrolled children. Secondary outcomes included antiviral dispensing per 1000 influenza diagnoses and inflation-adjusted costs of antiviral agents. Outcomes were calculated and stratified by age, acute versus prophylactic treatment, influenza season, and geographic region.

RESULTS
The analysis included 1 416 764 unique antiviral dispensings between 2010 and 2019. Oseltamivir was the most frequently prescribed antiviral (99.8%). Dispensing rates ranged from 4.4 to 48.6 per 1000 enrolled children. Treatment rates were highest among older children (12–17 years of age), during the 2017 to 2018 influenza season, and in the East South Central region. Guideline-concordant antiviral use among young children (&lt;2 years of age) at a high risk of influenza complications was low (&lt;40%). The inflation-adjusted cost for prescriptions was $208 458 979, and the median cost ranged from $111 to $151.

CONCLUSIONS
There is wide variability and underuse associated with influenza antiviral use in children. These findings reveal opportunities for improvement in the prevention and treatment of influenza in children.
Uma proposta de uso das ‘lentes da prática’ para refletir sobre o lugar da extensão no processo de internacionalização da Educação Superior
Authors: De Souza Stefani , Moraes Mário César Barreto , Leal Fernanda 
Published: November 2023

Neste estudo, propusemos uma reflexão teórica com argumentos que compreendem pesquisas baseadas na prática como uma perspectiva promissora para analisar o lugar da extensão na internacionalização da educação superior. Situada em uma conjuntura mais ampla, a busca pelo entendimento da complexidade da instituição universitária e do ambiente social contemporâneo demandam o uso de lentes de análise abrangentes. Nesse cenário, distintas visões de ‘extensão’ são concomitantes e estão em disputa. A realidade atual objetiva da extensão apresenta instrumentalidade em seu processo de institucionalização, no entanto, na prática, ainda há um grande grau de subjetividade. No caso da extensão na internacionalização, as lentes da prática são potencialmente oportunas para o estudo do fenômeno, pois consideramos a extensão uma dimensão aplicada do conhecimento gerado pela pesquisa e ensinado na sala de aula. Entendemos que a subjetividade na relação com a comunidade pode reduzir a instrumentalidade do processo de curricularização da extensão e aproximar os estudantes das aprendizagens fundamentais, e argumentamos que, tomando a prática como unidade de análise e construção epistemológica, podemos conhecer fenômenos sociais que emanam das práticas de extensão na internacionalização. Julgamos que o maior desafio está no campo operacional e, nesse sentido, as lentes da prática podem auxiliar no estudo da extensão na internacionalização, oferecendo significações para o fenômeno e atribuindo sentido a significados que mesmo teoricamente ainda são pouco investigados. Exploramos, de forma inicial, o caso do Eirenè-UFSC e propusemos a realização de estudos futuros que empreguem metodologias da prática para a análise empírica do fenômeno.
Death Penalty Revisited
Authors: Rarog Aleksey 
Published: November 2023

Death penalty as a type of criminal punishment is known in practically all the countries of the world. The problem of its moral justification and practical value has been discussed in the doctrine of criminal law for almost three centuries, starting with Cesare Beccaria’s «On Crimes and Punishments». The debates grew especially heated in the middle of the19th century in Germany, and, starting from the second half of the century, — in other countries, including Russia. However, there is still no consensus between the supporters and the opponents of the death penalty. In the criminal law science of Russia, both pre-revolutionary, Soviet and post-Soviet, the views of opponents of the death penalty prevail. Nevertheless, its supporters also defend the death penalty not in principle, but as a temporarily necessary means of combating the most dangerous crimes.
The Russian legislators have also repeatedly changed their attitude to this punishment: they abolished it, then returned it to the arsenal of criminal legal means. The first at tempt to abolish death penalty was undertaken by Empress Elisabeth Petrovna, but her efforts turned out to be weak and inconsistent and thus unsuccessful, as well as the timid steps of Catherine II. There were some attempts to abolish death penalty in Russia on the verge of the 19th and the 20th centuries, which also failed. The Provisional Government abolished death penalty in February 1917 only to reinstitute it three months later. The Soviets also abolished it several times, but brought it back a short time later. Currently, the possibility of applying the death penalty is provided for both by the Constitution and the Criminal Code of our country. However, its application is blocked by the Ruling of the Constitutional Court of the Russian Federation No. 1344-O-P dated November 19, 2009. In the article, the legality of the prohibition of the death penalty by the Constitutional Court of the Russian Federation is questioned; the author believes that the abolition of the death penalty is only possible by introducing the corresponding amendment to the Constitution of the Russian Federation.
Overview on Juvenile Primary Fibromyalgia Syndrome
Authors: Ahmed Abdelsamie Fadl  , Haizan, Abdulaziz Abdulelah I  , Faisal Abdullah Alharbi  , Hazazi, Aeshah Taher M  , Alahmari, Abdulkhaliq Yahya M  , Belgees Altigani Hamza Yousif  , Waleed Ali Alshehri  , Dhafer Saeed Dhafer  , Salma Rshed Altamimy  , Talal Rashid Alanazi  , Nader Saad Alqabbani  , Shahad Osamah Kadasah  
Published: November 2023

JPFS (juvenile primary fibromyalgia syndrome) is a musculoskeletal pain illness that affects children and adolescents. The intricacy of the clinical picture in JPFS has not been adequately characterized in the literature. JFMS symptoms are sometimes difficult to compare to adult fibromyalgia syndrome since many of them are "medically unexplained" and frequently overlap with other medical disorders. The etiology of the illness is multifaceted, with impaired central pain processing being a significant contributor. Musculoskeletal pain that is severe and pervasive is the defining symptom. Other signs and symptoms include headaches, stiffness, subjective joint swelling, sleep and mood disorders, and headaches. Multiple sensitive spots might be found during a physical examination. The diagnosis has certain criteria and is clinical. Early detection and treatment are crucial. The gold standard of care combines a variety of modalities, but most significantly, exercise and cognitive behavioral therapy. The outlook varies, and symptoms might last well into adulthood. Discussing the epidemiology, etiology, pathophysiology, clinical symptoms, diagnosis, and management of JPFS is the goal of the review.
CITY INFORMATION MODELING (CIM) COMO FERRAMENTA DE APOIO AO PLANEJAMENTO URBANO COM FOCO EM CONFORTO TÉRMICOS
Authors: Borges Marcos Martins , Rodrigues Ana Carolina Caldas , Oliveira Gabriella Dias de , Guimarães Tuanny Cristinny da Cunha 
Published: November 2023

Este artigo discute a necessidade de um planejamento urbano que prioriza a qualidade do ambiente construído e o conforto dos indivíduos, tendo em vista as mudanças climáticas e a necessidade de estratégias de mitigação do efeito destas. A partir do entendimento de que o espaço urbano se caracteriza por um organismo complexo, definido por diversas dimensões, faz-se necessário a adoção de ferramentas que possibilitem tratar suas especificidades para o alcance de um planejamento urbano eficiente e que proporcione um ambiente confortável termicamente. Sendo assim, o presente artigo tem por objetivo discutir o uso da tecnologia City Information Modeling (CIM) como ferramenta de apoio ao desenho urbano com foco no conforto térmico. Para esta pesquisa de caráter exploratório foi adotada como processo metodológico a revisão bibliográfica documental dos temas tocantes ao interesse desta pesquisa e apresentação de um estudo de caso. O principal resultado desta pesquisa se concentra no papel da ferramenta CIM como facilitadora na gestão eficiente dos parâmetros e na atuação conjunta dos diversos setores que atuam no planejamento urbano. Este artigo tem como principal contribuição reforçar o papel dos profissionais atuantes no planejamento urbano e afirmar a importância de ferramentas que melhorem a gestão do ambiente construído.
ESTUDOS DAS QUADRAS E LOTES EM CUIABÁ NO SÉCULO XVIII
Authors: Oliveira Vitória Roberta Miguel de , Galdino Yara da Silva Nogueira 
Published: November 2023

O artigo apresentado foi desenvolvido no projeto de pesquisa Casa Cuiabana: Arquitetura Residencial em Cuiabá durante o Período Colonial. Visando analisar a morfologia urbana de quadras e lotes do século XVIII, relacionando-a à tradição das cidades de origem portuguesa. Na análise da forma urbana, admitisse que a cidade resulta de múltiplas influências, como; acontecimentos históricos, contexto socioeconômico, características geográficas e demográficas. Esses elementos marcam a forma urbana, sobrepondo-se ao longo do tempo, registrando cada momento histórico. Registros que podem ser entendidos como palimpsestos, conforme Ozo (2009, apud Costa & Netto, 2017) representa camadas temporais sobrepostas, determinadas por mudanças econômicas e culturais, resultando em alterações no espaço urbano, revelando diferentes fases históricas da cidade. O centro histórico de Cuiabá inicia seu período de formação no século XVIII, passando por mudanças em seu espaço urbano. Segundo Rossi (1995) o traçado seria um dos fatos urbanos mais resistentes às transformações, constituindo muitas vezes em permanências de períodos históricos anteriores. Desta forma, esta pesquisa visou identificar as características dos quarteirões e lotes coloniais, sintetizando tipologias que pudessem ser associadas às características da tradição urbanística portuguesa e evolução urbana do território. Baseando-se na análise da planta de Cuiabá de 1786, e estudos de Teixeira (2012) sobre a formação do lote urbano na cidade de tradição portuguesa, identificou-se cinco tipologias de quarteirões. Cada um desses tipos apresenta características específicas, compondo o tecido urbano da Cuiabá setecentista.
Nurturing academic leadership: A quest for the ideal academic leadership style for Maldives higher education
Authors: Waheeda Aishath , Vasudevan Asokan , Hai Sam Toong , Balakrishnan Rajani 
Published: November 2023

Higher education leadership is an understudied area, especially at the departmental or faculty level. The current study explored preferred academic leadership styles as perceived by academic deans and their lecturers in Maldivian Higher Education Institutes (HEIs). A sequential explanatory mixed method design informed by post-positivist techniques was used in this study. In the first phase, the survey method was used to directly reach many respondents, administer the instruments and to collect the required data. from deans (N=20) and lecturers (N=170) from nine different HEIs. SPSS (Statistical Package for the Social Sciences) version 23 was used to analyze the data using descriptive statistics and inferential statistics such as means, percentages, standard deviations, independent sample t-test and Pearson correlation coefficients. In the second phase, a qualitative approach was used to explain, validate and to triangulate the quantitative findings. This phase used semi-structured interviews for purposively selected deans (N=5) and lecturers (N=16) from seven different HEIs. The interview transcripts were thematically analyzed and coded using the template analysis method. The most preferred academic leadership styles in Maldivian HEIs were found to be transformational, distributed, and transactional leadership styles, respectively. To enhance academic leadership in HEIs in the Maldives, this study recommends academic leaders to use transformative and distributive leadership behaviors, which would also help HEIs in the skill development of academic deans.
Akibat Hukum Pelaku Usaha Terhadap Produk Pangan Yang Tidak Bersertifikasi Halal
Authors: Citra Andita Nara , Widyanti Ikarini Dani 
Published: November 2023

Abstract :
Every pangan product made in Indonesia must have a halal certification before being sold to the general public. Halal certification is accomplished by applying a halal label to products that are produced and by including a halal declaration in the packaging. This action is intended to encourage the general population who do not consume unhealthy food to do so (haram). It is stated in Pasal 4 Undang-Undang No. 33 Tahun 2014 about Jaminan Produk Halal that products that are imported into, are manufactured in, and are distributed in Indonesia must be certified as halal. On the other hand, there are a lot of foods that are sold in stores that lack halal certification. The purpose of this study is to understand how the hukum that was expressed by the owner of a business selling pangan without a certification that it was permissible under Islamic and positive law.
Keywords : owner of a business; food product; certified halal.
Interactions between the protein barnase and co-solutes studied by NMR
Authors: Williamson Michael , Trevitt Clare , Kumar Yaswanth , Fowler Nicholas 
Published: November 2023

Abstract
The solubility, stability and function of proteins is critically dependent on the co-solutes (also described as excipients) present. There are many “rules of thumb” that have been used to select suitable co-solutes for different proteins to be stable and soluble, but very little theoretical basis for any of them. Some guidance is provided by the Hofmeister series, an empirical ordering of anions according to their effect on solubility and stability; and by osmolytes, which are small organic molecules produced by cells to allow them to function in stressful environments, such as high salt or pressure, or extremes of pH or temperature. Here we show that NMR titrations of the small protein barnase with selected Hofmeister anions and osmolytes can be used to measure and locate binding, and to separate the effects on the protein due to binding and to perturbation of the solvent. We describe a rationalisation of Hofmeister (and inverse Hofmeister) effects, which is similar to the traditional chaotrope/kosmotrope idea but based on solvent fluctuation rather than water withdrawal, and characterise how co-solutes affect protein stability and solubility, based on solvent fluctuations. This provides a coherent explanation for solute effects, and points towards a more rational basis for choice of excipients.
Robust Control of an Rotary-wing UAV with Suspended Load
Authors: Enriquez Jefferson Abraham , Galarza Tito Yvan , Cutipa Juan Carlos , Ferruzo Diego Paolo 
Published: November 2023

Abstract
There is a growing interest in unmanned aerial vehicles, which can be used to transport loads in emergency situations or to access difficult geography. In certain scenarios, the carried load is connected using nonrigid links attached to the vehicle’s center of gravity, creating a suspended configuration. An unmanned aerial vehicle with a suspended load is a complex system that needs to keep desired levels of performance and stability, despite the disturbances generated by the load oscillations and coupled dynamics. In this work, we design the robust control for an unmanned aerial vehicle with suspended load based in the H∞ norm and the loop shaping approach. The proposed controller is tuned to find the best robustness in terms of performance and stability, even in adverse scenarios with the presence of sensor noise, environmental disturbances and parameter uncertainties. The simulation results show the robust controller keeps good tracking, better disturbance rejections, and it is a straightforward alternative to be considered for complex systems.
A Heterogeneity Study on the Impact of Sustainable Economic Growth on Environmental Pollution: The Case of Shandong Province
Authors: Yue Junrong , Zhang Rongjie , Wu Changwei , Xu Yingkai 
Published: November 2023

Abstract
Sustainable economic development is often accompanied by increasingly prominent environmental problems, and it is important to explore the relationship between economic growth and environmental pollution. This paper combines the BP neural network algorithm in machine learning with traditional econometric methods to study the relationship between environmental quality and economic growth, using a fixed-effects panel model to quantify the relationship between environmental pollution and economic growth, as well as generalized method of moments (GMM) estimation to address the endogeneity of the variables, and the theory of the Environmental Kuznets Curve (EKC) to observe polynomials in the shape of the fitted curve and determine the location of the inflection point, and analyzed that wastewater discharge is expected to increase again in the coming years. Then, a BP neural network evaluation model was established to obtain the environmental quality evaluation value of Shandong Province. Finally, the spatial correlation and differences between GDP and environmental quality in Shandong Province are investigated using Moran's index and Dagum Gini coefficient, and the relationship between them is explored. On this basis, targeted recommendations for economic development and environmental governance in Shandong Province are made in terms of adjusting industrial structure, strengthening coordinated regional development, implementing differentiated environmental protection policies, and strengthening environmental monitoring and enforcement. Our study contributes to a deeper understanding of the relationship between economic growth and environmental pollution and provides important insights for policy formulation.
Formation Control of Quadrotor UAVs and Localisation Analyses Via Wireless Sensor Networks
Authors: Devery Jack , Gill Palvir Singh , Allen George , Shahra Essa , Idrissi Moad 
Published: November 2023

Abstract
In recent years, the cost-effectiveness of deploying and maintaining Unmanned Aerial Vehicles (UAVs), coupled with their capacity to operate in remote or hazardous environments inaccessible to human pilots, has garnered significant research attention in both military and civilian domains. The utilisation of multi-agent UAVs has experienced substantial growth, particularly for intricate tasks such as surveying and monitoring, necessitating extensive research and development efforts. This expansion demands more intricate control, communication, and coordination mechanisms. Assessing and analysing these multi-agent systems under flight dynamic conditions pose notable challenges. This paper proposes the development of a mathematical model for a leader-follower structured Quadrotor UAVs that accurately represents the dynamic behaviour while considering the ad-hoc networking system via COOJA. The aim is to construct a model that fulfils the need for a simulation environment, which researchers can employ to evaluate and analyse formation control mechanisms. Simulation results are presented from a case study to exemplify a potential application of this approach. A comparative assessment of performance between the proposed system and the traditional counterpart reveals enhanced leader-follower flight performance concerning attitude and position tracking while taking into consideration the ad-hoc networking infrastructure.
Surgical Treatment of Vertical Compressed Tibial Plateau Fracture with Temporary External Fixation Brace Combined with MIPPO Technique
Authors: Li Xu-song , Ye Lin , Wu Jun-le , Huang Li-ben , Huang Jie-feng 
Published: November 2023

Abstract
This study aims to evaluate the clinical effects of a temporary external fixation brace in conjunction with the minimally invasive percutaneous plate osteosynthesis (MIPPO) technique of vertical compressed tibial plateau fractures. A retrospective analysis of 12 patients with tibial plateau fractures with vertical compression changes from October 2019 to October 2020 was performed. All patients were treated with a temporary external fixator to correct the vertical shortening deformity, and then the MIPPO technique was used after reduction. All patients had satisfactory fracture reduction on postoperative imaging. The average operative time was 112.92 ± 21.47min, the times of fluoroscopy were 15.75 ± 3.16, the blood loss was 65.83 ± 10.82ml, the length of hospital stay was 12.92 ± 5.35 days, the average fracture healing time was 10.41 ± 1.5 weeks. The mean follow-up time was 23.75 ± 2.93 months. At the last follow-up, in 12 patients, the Rasmussen anatomical score was excellent in 9 patients (75.0%), good in 2 patients (16.7%), and fair in 1 patient (8.3%). The HSS score was 65.25 ± 3.31 after 1 month, 81.92 ± 1.69 after 6 months, 87.83 ± 1.41 after 1 year, and 92.25 ± 1.16 after last follow-up (F = 13.001, P༜0.001). No complications occurred in all patients during the follow-up period. For vertically compressed fractures of the tibial plateau, the use of temporary external fixators combined with the MIPPO technique can reach better correct the displacement of the vertically compressed, reducing soft tissue damage and the difficulty of surgical reduction, which is conducive to the recovery of joint function.