bluuebunny/crossref_metadata_2025_split huggingface dataset:
Отдаленные результаты иммуносупрессивной терапии у больных апластической анемией (опыт одного центра)
Authors: Шилова Елена Романовна , Романенко Н. А. , Чебыкина Д. А. , Глазанова Т. В. , Зенина М. Н. , Павлова И. Е. , Бессмельцев С. С. 
Published: October 2023

Background. Bone marrow transplantation-ineligible aplastic anemia (AA) is most effectively treated with combined immunosuppressive therapy (IST). It yields remissions in most patients. However, it has such disadvantages as frequent relapses, incomplete hematologic recovery, and clonal evolution risk. Besides, АА is not always treated according to standard regimens. For different reasons, some AA patients receive delayed therapy or IST mono-treatment predominantly with cyclosporine A (CsA).
Aim. To assess long-term IST outcomes in AA patients followed-up at the Russian Research Institute of Hematology and Transfusiology for 5 years after therapy onset.
Materials & Methods. The study enrolled 30 AA patients who received IST for more than 5 years (continuous follow-up of 5.5–33 years) with monitoring of the main hemogram parameters and PNH clone size. Patients were aged 19–73 years (median 29 years). There were 8 women and 12 men. Based on international criteria, severe AA (SAA) was initially diagnosed in 18 patients, and non-severe АА (NAA) was diagnosed in 12 patients. Combined IST was administered to 22 patients (18 SAA patients and 4 NAA patients), the remaining 8 patients received ATG (n = 1) and CsA (n = 7).
Results. A response to IST was achieved in 28 (93.3 %) out of 30 patients, 16 (53.3 %) of them showed complete remission. This paper documents the characteristics of hematologic recovery depending on the compliance with standard therapy regimens, as well as on the disease variant, development of late complications and clonal evolution, characteristics of pregnancy and childbirth in 4 female patients in remission. PNH clone increased in more than a half (10 out of 16) patients whose clone was initially > 2.6 %. Long-term clonal evolution to myeloid neoplasia (13 years after IST onset) was registered in 2 (6.7 %) patients with complete AA remission. Aseptic (avascular) osteonecrosis as complication was reported in 6 (20 %) followed-up patients.
Conclusion. The results of the study highlight the importance of and the need for early start and adherence to standard combined IST regimens aimed at optimum therapeutic effect in both SAA and NAA patients, as well as for long-term follow-up of patients after completing IST.
Experimental determination of Si, Mg, and Ca isotope fractionation during enstatite melt evaporation
Authors: Lu Wenhua , Weber Richard , Zhang Zhaofeng , Li Yuan 
Published: October 2023

Abstract
Evaporation of silicate materials from Earth or its precursors may be important in shaping their primordial compositions represented by undifferentiated meteorites, e.g., enstatite chondrites; however, the conditions under which evaporation occurs and the extent of evaporation-induced elemental and isotope fractionation remain uncertain. Here, we experimentally determine the volatility and isotope fractionation of Si, Mg, Ca, Nb, and Ta during enstatite melt evaporation at 2423–2623 K using a high-temperature conical nozzle levitator. Homogenous glasses are recovered after experiments; then we use EPMA and LA-ICP-MS to measure the elemental compositions, MC-ICP-MS to measure the Si and Mg isotopes, and TIMS to measure the Ca isotopes. Our results show that the evaporation rates of Si are larger than Mg, and the mean vapor/melt isotope fractionation factors (α = Rvapor/Rmelt; R = isotope ratio) are 0.99585 ± 0.00002 for 29Si/28Si and 0.98942 ± 0.00130 for 25Mg/24Mg. However, neither evaporative loss of Ca, Nb, and Ta nor Ca isotope fractionation was observed within analytical uncertainty. In conjunction with previous studies, we find that in an evaporation experiment the saturation degree (partial vapor pressure/equilibrium vapor pressure) of Si (SSi) is larger than SMg when Si is more volatile than Mg, and vice versa. If the Mg/Ca and Si/Ca ratios and isotopes in the bulk silicate Earth are attributed to the evaporation of enstatite chondrite-like precursors, evaporation temperatures &gt;5000 K and SSi &lt; SMg are required.
Bacterial communities structure in constructed wetlands for municipal and industrial wastewater treatment in Tanzania
Authors: Msaki Gerubin Liberath , Kaale Sadikiel E. , Njau Karoli Nicholas , Lyimo Thomas J. 
Published: October 2023

AbstractBacteria are the largest and most essential microorganisms in wastewater treatment systems. Despite the vital role bacteria play in enhancing wastewater treatment, its community structure and diversity remain poorly known. This study elucidated bacterial diversity and community structure in constructed wetlands (CWs) for municipal and industrial wastewater treatment using a culture-independent approach. Analysis of physicochemical parameters and Illumina high-throughput sequencing of V3 and V4 hypervariable regions of 16S rRNA gene bacterial community was performed. The results showed that the Proteobacteria were dominant (48.66%) phyla across all CWs. The Gammaproteobacteria class (27.67%), family Comamonadaceae (35.79) and Genus Flavobacterium (4.35%) were dominant across studied CWs. Bacterial abundance increased from the inlet to the outlet, with CWs having a higher abundance around the outlet, showing a good performance. The Shannon–Wiener index showed the highest species diversity (H = 1.45) in Banana Investment Limited CWs treating industrial wastewater. This study found significant bacterial diversity across studied CWs, with higher abundance and diversity at the outlet indicating better performance than those with low abundance and diversity at the outlet. We recommend a longitudinal investigation at each CWs section to confirm and establish the role of bacterial diversity on the performance pattern of CWs.
Sol–gel catalysts immobilized on stainless steel meshes for Ba2+ removal in a continuous flow process: An experimental design
Authors: Bueno Lisandra N. , Fidelis Michel Zampieri , Abreu Eduardo , Tusset Angelo Marcelo , Gonçalves Lenzi Giane 
Published: October 2023

Abstract

This study describes the use of a continuous flow system for photocatalytic reactions employing a TiO2 sol–gel structured catalyst. The catalyst was immobilized on various stainless steel meshes to investigate the barium(II) removal. To verify its photocatalytic activity, batch tests were carried out and the results were compared to the commercial catalyst P25. Effects of thermal treatment on the structured catalyst were investigated. The continuous flow photocatalytic tests were conducted under different experimental conditions through an experimental design to verify the effect of the parameters (pH and volume flow). The results of the batch tests indicated that the TiO2 sol–gel catalyst showed very similar activity to the TiO2 P25 when used in powder suspension (32% reduction of Ba2+). In the continuous flow process, maximum adhesion of catalysts on meshes was found at a calcination temperature of 623 K. The experimental design indicated the pH as a significant parameter in the studied conditions. It was observed that at pH levels close to 7, also indicated by the study of the zero charge point and lower flow rates, it was possible to obtain ∼20% removal of Ba2+ ions, in a continuous flow reactor with a residence time of 83 min.
Degradation of bisphenol A by persulfate activation of MoS2 composite iron tailings
Authors: Zhang Han , Wu Xiaodong , Yang Shaopeng , Xue Gang , Gong Cairong , Wang Li , Duan Xinhui , Wang Yaping , Tian Guangyan , Zhan Sihui 
Published: October 2023

Abstract

In this paper, molybdenum disulfide was grown on the surface of iron-containing tailings by hydrothermal method, and a series of highly efficient activated persulfate (PMS) iron-based catalysts were successfully prepared. The results show that in the CTM 1–200/PMS system, the additional ratio of tailings and the hydrothermal temperature have important effects on the catalyst. The catalyst prepared under the conditions of CT:MoS2 (molar ratio 1:1) and hydrothermal temperature of 200 °C (CTM 1–200) had the best degradation effect on BPA, and the degradation effect was increased by four times. The reason for the improvement of degradation efficiency is that the introduction of MoS2 accelerates the REDOX cycle between Fe(II)/Fe(III), and the reduction of Fe(III) is mainly related to Mo(IV), while the reduction capacity of S is relatively weak. Molybdenum disulfide/iron tailing composite material provides a way for tailings to solve the problem of water pollution.
Assessment of semen parameters after microsurgical varicocelectomy in men from infertile couples
Authors: Akilov F. A. , Mukhtarov Sh. T. , Shomarufov A. B. , Abbosov Sh. A. , Shavakhabov Sh. Sh. , Mirkhamidov D. Kh. , Giyasov Sh. I. , Kasimov S. S. , Abdukarimov O. O. 
Published: October 2023

Introduction. Varicocele is one of the frequently identified and corrected causes of male subfertility. However, varicocele correction results in improved sperm quality only in 60 – 70% of subfertile men. At the same time, it is not completely clear which semen parameters improve to a greater extent, and what is the proportion ofpatients with an improvement in parameters to normozoospermia.Objectives. To assess qualitative changes in semen after microsurgical varicocelectomy according to WHO 2021 Laboratory manual of semen analysis.Materials & methods. This study analysed qualitative changes in sperm in infertile men after varicocelectomy. All patients had a clinical varicocele, for which microsurgical varicocelectomy was performed. The study included 100 subfertile men with varicocele and abnormal sperm parameters.Results. In the postoperative period (after 6 months), the main semen parameters increased significantly. Also, the proportion of patients with isolated asthenozoospermia decreased by 22% (p < 0.05), the proportion of patients with oligoasthenozoospermia decreased by 14% (p < 0.05). The proportion of patients with normospermia was 35% (p < 0.0001). In patients with oligoasthenozoospermia significant improvement in sperm to normospermia was observed in 19% of cases.Conclusions. Varicocele repair leads to an improvement in the quality of the ejaculate in subfertile men with palpable varicocele and pathozoospermia, with the most significant improvement in sperm motility. However, only in a third of patients semen quality improved to normal levels. Additionally, varicocelectomy demonstrated high efficacy in patients with oligoasthenozoospermia.
Comparative evaluation of simulators for practising fluoroscopy-guided renal pelvic puncture
Authors: Gadzhiev N. K. , Gorelov D. S. , Mishchenko A. A. , Britov V. P. , Kharchilava R. R. , Sharafutdinov E. F. , Petrov S.  B. , Shkarupa D. D. 
Published: October 2023

Introduction. The skill of puncture of the kidney pelvicalyceal system is one of the basic urological skills, as it is used for various surgical interventions. There are different training models, from laboratory animals to virtual reality simulators.Objective. To evaluate a non-biological model of the pelvicalyceal system puncture simulator UroATOM (“Alfa-Rhythm”, Russian Federation) and to compare it with a virtual reality simulator PERC MentorTM (“Simbionix”, Beit Golan, Israel).Materials & methods. The results of fluoroscopic guided puncture training were analyzed among 50 physicians. The specialists were divided into two equal groups by experience: group 1 — beginners, group 2 — experienced urologists. In phase 1, both simulators were evaluated by the physicians using Likert questionnaires. In phase 2, the puncture results in beginners were evaluated before and after the UroATOM simulator practise.Results. Comparing the indices of both simulators showed that UroATOM was rated as more convenient to use (p = 0.0001) and cheaper (p < 0.0001). The analysis of the puncture performance by "beginners" before and after UroATOM training revealed a statistically significant improvement in the performance. The puncture time index improved by 79 seconds. The index of fluoroscopy duration decreased by 40.9 seconds. The number of puncture attempts decreased by 1.4 times. The amount of contrast decreased by 5.4 ml.Conclusions. The UroATOM simulator is effective for training young specialists in fluoroscopy-guided renal cavity puncture.
Russia and China: Prospects for the Development of Urban Agglomerations
Authors: Vulfovich R. M. 
Published: October 2023

This research is aimed at studying the development of cities and agglomerations, which is an urgent problem equally for the People’s Republic of China and the Russian Federation. The level of urbanization increases with the development of territories, which makes it necessary to comprehend the processes taking place in urbanized regions and make management decisions to improve the quality of life and equalize it throughout the territory. Within the framework of these processes, the role of core cities remains, which are the centres of preferential development for the entire urban system as a whole.Aim. Comparative analysis of development trends in urbanized regions of China and Russia.Tasks. To analyse the main parameters of the quality of life in large cities of Russia and China. To consider the main trends in the development of urban agglomerations in the direction of its alignment. To determine the development and possibilities of mutual use of the experience of both countries in this process.Methods. The study uses a systematic approach with elements of a structural and functional approach and a comparative research method.Results and conclusion. As the main trends in the development of urbanized regions of Russia and China, the following are highlighted: the growth of the scale of territories and the concentration of a significant population on them, the associated aggravation of a number of problems, such as increasing competition in the integrated labour market, standardization and unification of the p rovision of basic services, increasing burden on local budgets and often limiting the autonomy of municipalities, the need to improve transport systems to increase the mobility of the population throughout the territory of the agglomeration.
Economic and Political Factors Affecting the Rapprochement of Iran and the EAEU
Authors: Ivannikov N. S. , Chulabi D. G. 
Published: October 2023

Aim. Identify economic and political factors that are beneficial to Iran — EAEU relations.Tasks. Identify the prerequisites of the economic and political point of view, both in history and at the present stage, which would explain the prospects for rapprochement between Iran and the Eurasian Economic Union.Methods. The methods of scientific research in the work should include analysis (to understand the impact of historical events in Iran), as well as the deductive method and synthesis, which will allow to identify a set of factors affecting the improvement of relations between Iran and the EAEU.Results. The “White Revolution” promoted by the West in Iran was not viable and eventually pushed Iran to cho ose a more original way and ways of international cooperation, taking into account national specificity or following the policy of non-interference, which becomes the integration within the EAEU. Another favorable political aspect for Iran is cooperation with Russia , which strengthens confidence that the coun try will not be influenced by political activities and is based on mutual respect and equality. The current economic agreements demonstrate mutual willingness to develop the existing economic relations, as well as have a positive impact on foreign trade and allow taking into account each other’s mutual interests in economic terms, and contribute to the resolution of certain problems.Conclusion. In view of the considered political and economic factors, the rapprochement between Iran and the EAEU can indeed be considered a promising and relevant political trend, despite the existing obstacles. Both sides are positive about strengthening their relations, so it is important to continue working to remove the existing obstacles to the development of cooperation.
Instruments of Social Policy of the Eurasian Economic Union (Part 2)
Authors: Rubtsov G. G. , Misko O. N. 
Published: October 2023

Aim. Taking into account the above, the purpose of the study was to analyze the patterns of development of the social policy of the Russian Federation, the republics of Belarus, Kazakhstan, Kyrgyzstan and Armenia, to consider their weaknesses and points of growth in order to identify the potential for strengthening integration ties based on the unification of social development tools.Task. To analyze various areas of social life of the EAEU member countries, identify similarities in development trends in order to create a basis for the formation of unified socio-economic transformations. To demonstrate social tools for the development of «transinstitutional interaction» within the boundaries of the Eurasian Economic Union.Methods. The following methods were used i n the article: comparative an alysis — to compare the effectiveness of social policy instruments in the EAEU countries. The novelty lies in the improvement of the integration processes of the Eurasian integration countries with the help of the proposed author’s approach to unify the social policies of the EAEU member countries on the basis of “transinstitutional cooperation”.Results. A comprehensive analysis of social policy instruments (migration, youth, labor, housing, etc.) of all participants in the Eurasian integration was carried out. Recommendations are proposed for improving social tools within the framework of “transinstitutional cooperation” of the EAEU states.Conclusion. The analysis of the instruments of social policy laid down the priorities in the development of the mechanisms of “transinstitutional cooperation” by the members of the EAEU, expressed in the author’s recommendations in this study. The Republics of Kyrgyzstan, Armenia and Kazakhstan should focus on developing a unified strategy for youth and migration policies. The Russian Federation and the Republic of Belarus should focus on population aging, providing older citizens with pension savings, and encouraging the development of family and motherhood institutions. This is disclosed in more detail in separate blocks of the study devoted to specific areas of social development of the EAEU countries.
EAEU’s Human Potential: New Risks and Opportunities for Development
Authors: Yurova N. V. 
Published: October 2023

This study is aimed at studying human potential, its development and implementation in the Eurasian Economic Union (EAEU). Taking into account the commitments made by the countries of the Union to achieve the Sustainable Development Goals (SDGs) in accordance with Agenda 2030 and under sanctions pressure from hostile countries.Aim. To present the human potential of the integration association as a complex phenomenon of the socio-economic relations of the integrating countries, as well as to identify the emerging risks and offer practical recommendations for reproducing the human potential within the EAEU.Tasks. To trace the dynamics of indicators of development and realization of human potential in each country of the EAEU and the aggregate human potential of the EAEU, to reveal the features of reproduction of human potential by dividing it into qualitative and functional forms, to identify modern risks for reproduction of human potential of the EAEU and new opportunities for development.Methods. To compare indicators of human development of the EAEU countries, the method of comparative analysis is used. In the part of the human potential of the EAEU, it is proposed to take into account new risks for ensuring sustainable human development in the integration association, which make it possible to make methods of analysis and synthesis, induction and statistical method.Results. Based on the analysis of the dynamics of development of such forms of human potential as health potential, educational potential and labor potential, accumulated problems, modern challenges and risks for reproduction of human potential of each EAEU country.Conclusion. The EAEU can no longer remain only an economic integration project, and it is time to expand the horizons of interaction between countries, including on the sphere of development and the realization of human potential. By taking into account new risks, countries need to coordinate the directions of development of the EAEU’s total human potential within the framework of commitments to achieve the Sustainable Development Goals in accordance with Agenda 2030 and under the conditions of ongoing sanctions pressure from hostile countries.
PENGARUH MEDIA DOMINO CARD TERHADAP BERPIKIR KRITIS DAN HASIL BELAJAR PADA PEMBELAJARAN PENDIDIKAN PANCASILA SISWA KELAS IV SEKOLAH DASAR
Authors: Aisah Marifatul , Wahju Andjariani Endang , Rahayu Sri Wulan Budhi 
Published: October 2023

The purpose of this study is to determine the influence of Domino Card media on critical thinking and student learning outcomes in grade IV elementary school education subjects. Lack of critical thinking skills and learning outcomes due to students less enthusiasm in learning and the media used is less interesting and boring so it is difficult to accept and understand the material. Improving critical thinking skills and student learning outcomes requires learning media such as Domino Card media. This researchis a quantitative research with experimental methods. Theresearch uses quantitative Nonequivalent Control Group Design using control classes and experiments. The study was conducted at SDN Pabean II with a population of 40 students and a sample of 20 students per class. The results of the first study conducted to determine the influence of Domino Card media on critical thinking by conducting a normality test obtained sig results of 0.083 > 0.05 can be concluded that the data obtained are distributed normally. Based on the results of the hypothesis, the value of t count 6.394 and t table 2.024, based on the decision of the hypothesis test t count 6.394 > ttable 2.024, H0 was rejected showing the influence of Domino Card media on students' critical thinking.The results of the second study were conducted to determine the influence of Domino Card media on learning outcomes by conducting a normality test obtained sig results of 0.200 > 0.05 can be concluded that the data obtained are distributed normally. Based on the results of the hypothesis, the calculated t value is 5.039 and t table 2.024, based on the hypothesis test decision of the calculated t value of 5.039 > ttable 2.024, H0 is rejected showing the influence of Domino Card media on student learning outcomes.