bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rethinking neurodegenerative diseases: neurometabolic concept linking lipid oxidation to diseases in the central nervous system
Authors: Helgudóttir Steinunn Sara , Mørkholt Anne Skøttrup , Lichota Jacek , Bruun-Nyzell Preben , Andersen Mads Christian , Kristensen Nanna Marie Juhl , Johansen Amanda Krøger , Zinn Mikela Reinholdt , Jensdóttir Hulda Maria , Nieland John Dirk Vestergaard 
Published: November 2023

Abstract
Currently, there is a lack of effective medicines capable of halting or reversing the progression of neurodegenerative disorders, including amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis, or Alzheimer's disease. Given the unmet medical need, it is necessary to reevaluate the existing paradigms of how to target these diseases. When considering neurodegenerative diseases from a systemic neurometabolic perspective, it becomes possible to explain the shared pathological features. This innovative approach presented in this paper draws upon extensive research conducted by the authors and researchers worldwide. In this review, we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative diseases. We provide an overview of the risk factors associated with developing neurodegenerative disorders, including genetic, epigenetic, and environmental factors. Additionally, we examine pathological mechanisms implicated in these diseases such as oxidative stress, accumulation of misfolded proteins, inflammation, demyelination, death of neurons, insulin resistance, dysbiosis, and neurotransmitter disturbances. Finally, we outline a proposal for the restoration of mitochondrial metabolism, a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.
Gabapentinoids for the treatment of stroke
Authors: Zhang Ying , Zhang Chenyu , Yi Xiaoli , Wang Qi , Zhang Tiejun , Li Yuwen 
Published: November 2023

Abstract
Gabapentinoid drugs (pregabalin and gabapentin) have been successfully used in the treatment of neuropathic pain and in focal seizure prevention. Recent research has demonstrated their potent activities in modulating neurotransmitter release in neuronal tissue, oxidative stress, and inflammation, which matches the mechanism of action via voltage-gated calcium channels. In this review, we briefly elaborate on the medicinal history and ligand-binding sites of gabapentinoids. We systematically summarize the preclinical and clinical research on gabapentinoids in stroke, including ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, seizures after stroke, cortical spreading depolarization after stroke, pain after stroke, and nerve regeneration after stroke. This review also discusses the potential targets of gabapentinoids in stroke; however, the existing results are still uncertain regarding the effect of gabapentinoids on stroke and related diseases. Further preclinical and clinical trials are needed to test the therapeutic potential of gabapentinoids in stroke. Therefore, gabapentinoids have both opportunities and challenges in the treatment of stroke.
Effects of mesenchymal stem cell on dopaminergic neurons, motor and memory functions in animal models of Parkinson's disease: a systematic review and meta-analysis
Authors: Park Jong Mi , Rahmati Masoud , Lee Sang Chul , Shin Jae Il , Kim Yong Wook 
Published: November 2023

AbstractParkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, and although restoring striatal dopamine levels may improve symptoms, no treatment can cure or reverse the disease itself. Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson's disease. Mesenchymal stem cells are considered a promising option due to fewer ethical concerns, a lower risk of immune rejection, and a lower risk of teratogenicity. We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function, memory, and preservation of dopaminergic neurons in a Parkinson's disease animal model. We searched bibliographic databases (PubMed/MEDLINE, Embase, CENTRAL, Scopus, and Web of Science) to identify articles and included only peer-reviewedin vivointerventional animal studies published in any language through June 28, 2023. The study utilized the random-effect model to estimate the 95% confidence intervals (CI) of the standard mean differences (SMD) between the treatment and control groups. We use the systematic review center for laboratory animal experimentation's risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment. A total of 33 studies with data from 840 Parkinson's disease model animals were included in the meta-analysis. Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test. Among the stem cell types, the bone marrow MSCs with neurotrophic factor group showed largest effect size (SMD [95% CI] = –6.21 [–9.50 to –2.93],P= 0.0001,I2= 0.0 %). The stem cell treatment group had significantly more tyrosine hydroxylase positive dopaminergic neurons in the striatum ([95% CI] = 1.04 [0.59 to 1.49],P= 0.0001,I2= 65.1 %) and substantia nigra (SMD [95% CI] = 1.38 [0.89 to 1.87],P= 0.0001,I2= 75.3 %), indicating a protective effect on dopaminergic neurons. Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route (SMD [95% CI] = –2.59 [–3.25 to –1.94],P= 0.0001,I2= 74.4 %). The memory test showed significant improvement only in the intravenous route (SMD [95% CI] = 4.80 [1.84 to 7.76],P= 0.027,I2= 79.6 %). Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson's disease. Further research is required to determine the optimal stem cell types, modifications, transplanted cell numbers, and delivery methods for these protocols.
Sowing the seeds of millet revolution: The extraordinary odyssey of architect of the millet revival movement–– Dr. Khader Valli Dudekula
Authors: Saniya C K , Nair Parvathy G , Karthika A P , Remya E 
Published: November 2023

This article highlights the extraordinary odyssey of Dr Khader Valli Dudekula, a visionary driving the Millet Revival Movement. Set amidst the backdrop of the International Year of Millet, the article aims to inspire and motivate readers by exploring the legacy of this millet reviver. Khader passionately propagates and preaches the manifold health benefits of millets, the significance of good agricultural practices, and the transformative power of a wholesome lifestyle. His life is an exemplary model, with 30 years of dedicated experiments with millets and advocacy, earning him the prestigious Padma Shri award.
Data collected from online sources, newspapers, and government sites reveal the significant contributions of Dr Valli. Through his dedicated work, he explored the medicinal properties of various grains, which he named “Siridhanyalu.” This concept closely aligns with Ayurveda's ideology that “ahara” (food) acts as medicine, which is central to promoting overall health.
Incorporating Dr Khader Valli Dudekula's wisdom reinforces the potential of traditional practices and millets to promote health and well-being. By embracing this perspective, it ignites the resurgence of millets and underscores disease-specific dietary plans. This integration yields remarkable healing outcomes, fostering a healthier, happier world through the potential of Ayurveda.
Traditional and common millet-based food recipes of the tribal communities of Arunachal Pradesh
Authors: Bhardwaj Yashpal , Taboh Mumtam , Pulicherla Yugandhar , Cheemanapalli Srinivasulu , Bhuyan Birina , Mathapati Shiddamallayya 
Published: November 2023

Abstract

BACKGROUND:
Millets have been cultivated in Arunachal Pradesh for generations, vital to the state's food security and dietary practices. Preserving and promoting culinary traditions not only benefits the local communities but also contributes to the global movement towards a more sustainable and diverse food future. The present study aims to document the common millets based food recipes traditionally prepared in Arunachal Pradesh.

MATERIALS AND METHODS:
The millet-based food recipes were documented from the ethnic tribal people. This study documented different types of millet-based recipes including millet type, ingredients, recipe type, method of preparation, recipe name in the local languages, and nutritional benefits of millet recipes.

RESULTS:
The study documented 11 types of millet-based food recipes from the ethnic tribes of Arunachal Pradesh, such as Adi, Apatani, Nyishi, Monpa, and Idu Mishmi. Finger millet is predominantly used to prepare food recipes followed by sorghum and kodo millet. Various ingredients, including local vegetables, milk, egg, ghee, coconut, sugar, etc., are used along with millet flour for food preparation. Various types of cooking techniques, such as steaming, frying, and boiling, have been adopted to prepare these dishes. Apong, a type of alcoholic beverage commonly served during tribal festivals in Arunachal Pradesh, is the most common item prepared mostly with rice and finger millet.

CONCLUSION:
The present study revealed that various millet-based food recipes are used by local tribes of Arunachal Pradesh.
Prenatal Ultrasound Diagnosis of Unilateral Pulmonary Agenesis
Authors: Reyna-Villasmil Eduardo , Briceño-Sanabria Liliana , Briceño-Sanabria Juan Carlos , Briceño-Pérez Carlos 
Published: November 2023

Abstract
Pulmonary agenesis (PA) is a rare developmental malformation, with a frequency of approximately 1 in 10–15,000 pregnancies. Unilateral PA is often associated with other congenital anomalies, whereas bilateral PA is fatal. Prenatal diagnosis is rare and is diagnosed more frequently in the postnatal period than in the prenatal period. Is a challenge that may be difficult as it shares similar features with other more common pathologies. Ultrasound plays a crucial role in early diagnosis and management. Ultrasonographic findings for a correct prenatal diagnosis include mediastinum displacement with the absence of parenchymal or cystic tissue, decreased thoracic volume, an elevated diaphragm, cardiac axis deviation, and a hemithoracic cavity largely occupied by the heart. Cases of right PA have a worse prognosis compared to left PA, probably due to higher frequency of cardiac and great vessel abnormalities. A rare case of early prenatal ultrasound diagnosis of unilateral fetal PA, at 18 weeks of gestation, is reported.
Analysis of Student Conceptions and Conceptional Changes about Chemical Equilibrium Materials in Concentration Factors
Authors: Novita Dian , Suyono Suyono , Suyatno Suyatno 
Published: November 2023

Objective: This study aims to determine the conception and changes in the conception of the concentration factor in chemical equilibrium material. Method: The method used in this study is a mixed method, which is a combination of qualitative and quantitative methods, namely the Concurrent Embedded Strategy, which is a combination of qualitative methods and quantitative methods carried out at the same time. Results: The test instruments provided can reduce the misconceptions that exist in students when viewed from a comparison of the number of students who experience misconceptions from 13.33% in the first stage to 7.00% in the last stage. Students understand enough about chemical equilibrium shifts but still need clarification, especially in writing down changes in reaction equations when chemical equilibrium is disturbed and analyzing phenomena using metacognitive examples of a concept in their surroundings. Novelty: This research reveals that students' misconceptions can be reduced using worksheets with five processing stages. This novelty can provide (1) solutions related to identifying students' misconceptions and (2) reducing students' misconceptions regarding chemical equilibrium concentration factors.
Dredging Engineering Special Topics
Authors: Miedema Sape 
Published: November 2023

In dredging, production estimating is carried out mainly with analytical physical models of the different dredging processes. Slurry transport of settling slurries and cutting processes in sand, clay and rock are already covered in two other books by the author. Other processes like hopper sedimentation and erosion, water jet fluidization, cutter head spillage, pump/pipeline dynamics and clamshell dredging are covered in this Special Topics Edition.
New topics may be added in the near future.
Frequency of Catheter-Related Bacterial Infection in End Stage Renal Disease Patients on Hemodialysis
Authors: Fatima Sonia  , Irfan Ahmad  , Salman Tahir Shafi  , Sana Ashraf  
Published: November 2023

Objective: To determine the frequency of catheter related bacterial infections among the patients on hemodialysis due to end stage renal disease.
Study Design: Cross sectional study
Place and Duration of Study: Department of Nephrology, Sharif Medical City Hospital, Lahore Pakistan, from 6 Months i.e.,Jun 2021 to Oct 2021.
Methodology: After meeting the inclusion and exclusion criteria 171 patients were enrolled. Tips of the catheters were removed by the surgeon and transferred to laboratory in a sterile container, while at least two blood culture samples were taken before removing the catheter. Catheter related bacterial infections were noted.
Results: In this study the most common catheter related bacterial infection in ESRD cases on hemodialysis was blood stream tunnel infection noted in 48.5% patients followed by, infective endocarditis noted in 28.1%, echo vegetation in 26.3% patients, tunnel infection in 25.1% and exit site infection in 23.4% patients.
Conclusion: The most common catheter related bacterial infection in ESRD cases on hemodialysis was blood stream tunnel infection followed by, infective endocarditis, echo vegetation, tunnel infection and exit site infection patients.
Routine Dental Polishing for Oral Health
Authors: Brett Kendra , Horton Jennifer 
Published: November 2023

What Is the Issue?

Professional dental care is important to help maintain oral health. Routine dental cleaning usually includes both scaling and polishing. Scaling is the removal of plaque and tartar from the crown and root surfaces of teeth. Polishing is the removal of residual plaque and external stains from the teeth.
To support decisions about the optimal components for professional dental cleaning, it is important to understand the potential benefits and harms of routine dental polishing when compared to no routine dental polishing.

What Did We Do?

We searched for clinical and cost-effectiveness literature comparing routine dental polishing with no routine dental polishing. We also looked for evidence-based guidelines that provide recommendations about the use of routine dental polishing for the maintenance of oral health in adults and children.
An information specialist conducted a search of peer-reviewed and grey literature sources published between January 1, 2018, and September 28, 2023.
Documents were excluded if we could not isolate the effects of dental polishing from other dental procedures or if polishing techniques were used for a purpose other than the routine polishing of teeth.

What Did We Find?

We did not find any studies directly evaluating the clinical or cost-effectiveness of routine dental polishing versus no routine dental polishing, or guidelines about the use of routine dental polishing, that met the inclusion criteria for this review.
We identified limited literature that examines the combined effects of routine scaling and polishing. Research is needed that distinguishes the effects of routine dental polishing from the effects of other dental procedures.

What Does This Mean?

Without comparative clinical or cost-effectiveness evidence about routine dental polishing versus no routine dental polishing, decision-makers may also wish to consider that patients value routine scaling and polishing, and that the cost of dental care may be a barrier to visiting the dentist for some people.
New polishing methods, such as air powder polishing, may also be useful to consider when making decisions about routine polishing to support dental health. These methods include some of the benefits of scaling and may present opportunities to reduce periodontal inflammation or the length of a dental appointment.
Simulating multi-hazard event sets for life cycle consequence analysis
Authors: Iannacone Leandro , Otárola Kenneth , Gentile Roberto , Galasso Carmine 
Published: November 2023

Abstract. In the context of natural hazard risk quantification and modeling of hazard interactions, some literature separates “Level I” (or occurrence) interactions from “Level II” (or consequence) interactions. The Level I interactions occur inherently due to the nature of the hazards, independently of the presence of physical assets. In such cases, one hazard event triggers or modifies the occurrence of another (e.g., heavy rain and flooding; liquefaction and landslides triggered by an earthquake), thus creating a dependency between the features characterizing such hazard events. They differ from Level II interactions, which instead occur through impacts/consequences on physical assets/components and systems (e.g., accumulation of physical damage or social impacts due to earthquake sequences, landslides due to the earthquake-induced collapse of a retaining structure). Multi-hazard Life Cycle Consequence (LCCon) analysis aims to quantify the consequences (e.g., repair costs, downtime, casualty rates) throughout a system’s service life and should account for both Level I and II interactions. The available literature generally considers Level I interactions – the focus of this study – mainly defining relevant taxonomies, often qualitatively, without providing a computational framework to simulate a sequence of hazard events incorporating the identified interrelations among them. This paper addresses this gap, proposing modeling approaches associated with different types of Level I interactions. It describes a simulation-based method for generating multi-hazard event sets (i.e., a sequence of hazard events and associated features throughout the system’s life cycle) based on the theory of competing Poisson processes. The proposed approach incorporates the different types of interactions in a sequential Monte Carlo sampling method. The method outputs multi-hazard event sets that can be integrated into LCCon frameworks to quantify interacting hazard consequences. An application incorporating several hazard interactions is presented to illustrate the potential of the proposed method.
Earth System Model Aerosol–Cloud Diagnostics (ESMAC Diags) package, version 2: assessing aerosols, clouds, and aerosol–cloud interactions via field campaign and long-term observations
Authors: Tang Shuaiqi , Varble Adam C. , Fast Jerome D. , Zhang Kai , Wu Peng , Dong Xiquan , Mei Fan , Pekour Mikhail , Hardin Joseph C. , Ma Po-Lun 
Published: November 2023

Abstract. Poor representations of aerosols, clouds, and aerosol–cloud interactions (ACIs) in Earth system models (ESMs) have long been the largest uncertainties in predicting global climate change. Huge efforts have been made to improve the representation of these processes in ESMs, and the key to these efforts is the evaluation of ESM simulations with observations. Most well-established ESM diagnostics packages focus on the climatological features; however, they lack process-level understanding and representations of aerosols, clouds, and ACIs. In this study, we developed the Earth System Model Aerosol–Cloud Diagnostics (ESMAC Diags) package to facilitate the routine evaluation of aerosols, clouds, and ACIs simulated the Energy Exascale Earth System Model (E3SM) from the US Department of Energy (DOE). This paper documents its version 2 functionality (ESMAC Diags v2), which has substantial updates compared with version 1 (Tang et al., 2022a). The simulated aerosol and cloud properties have been extensively compared with in situ and remote-sensing measurements from aircraft, ship, surface, and satellite platforms in ESMAC Diags v2. It currently includes six field campaigns and two permanent sites covering four geographical regions: the eastern North Atlantic, the central US, the northeastern Pacific, and the Southern Ocean. These regions produce frequent liquid- or mixed-phase clouds, with extensive measurements available from the DOE Atmospheric Radiation Measurement user facility and other agencies. ESMAC Diags v2 generates various types of single-variable and multivariable diagnostics, including percentiles, histograms, joint histograms, and heatmaps, to evaluate the model representation of aerosols, clouds, and ACIs. Select examples highlighting the capabilities of ESMAC Diags are shown using E3SM version 2 (E3SMv2). In general, E3SMv2 can reasonably reproduce many observed aerosol and cloud properties, with biases in some variables such as aerosol particle and cloud droplet sizes and number concentrations. The coupling of aerosol and cloud number concentrations may be too strong in E3SMv2, possibly indicating a bias in processes that control aerosol activation. Furthermore, the liquid water path response to a perturbed cloud droplet number concentration behaves differently in E3SMv2 and observations, which warrants further study to improve the cloud microphysics parameterizations in E3SMv2.