bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Acute Kidney Injury after Moderate Hypothermic Circulatory Arrest in Hemiarch Replacement
Authors: Nishigawa Kosaku , Hirota Takafumi , Hidaka Hideaki , Horibe Tatsuya , Takaki Jun , Yoshinaga Takashi , Fukui Toshihiro 
Published: October 2023

Background. The aim of this study was to clarify the incidence and risk factors for acute kidney injury (AKI) in patients undergoing hemiarch replacement (HAR) under moderate hypothermic circulatory arrest (MHCA) with retrograde cerebral perfusion (RCP). Methods. We retrospectively analyzed patients who underwent HAR under MHCA with RCP at our institution between April 2015 and July 2022. Exclusion criteria were preoperative dialysis, single kidney, and lack of preoperative plasma creatinine data. The study endpoint was the incidence of postoperative AKI, defined using the Kidney Disease: Improving Global Outcomes criteria. Multivariate logistic regression analysis was performed to identify the risk factors for postoperative AKI. Results. One hundred and seventy-nine patients were included in this study. The most common indications for HAR were thoracic aortic aneurysm (n = 107) and acute aortic dissection (n = 57). Concomitant procedures, most frequently aortic valve surgery, were performed in 104 (60.5%) patients. Median circulatory arrest time and minimum rectal temperature were 15 minutes (interquartile range, 11 to 19) and 27.4°C (interquartile range, 25.9 to 28.1), respectively. Operative mortality was 1.1%. The incidence of postoperative AKI was 37.8%. Multivariate analysis showed that acute aortic dissection (odds ratio, 4.57; 95% confidence interval (CI), 2.13–10.14;

P

< 0.001) and longer operating time (odds ratio, 1.01; 95% CI, 1.00-1.01;

P

= 0.001) were independent predictors for postoperative AKI. Conclusions. Acute aortic dissection and longer operating time were risk factors for postoperative AKI in patients undergoing HAR under MHCA with RCP. In contrast, neither circulatory arrest time nor minimum rectal temperature was a risk factor for AKI. This may be due to the short duration of circulatory arrest.
O estar em comum de Cristina Rivera Garza
Authors: Kaspar Katerina Blasques 
Published: October 2023

Este artigo se trata de uma aproximação inicial à obra de Cristina Rivera Garza, escritora e professora mexicana estabelecida nos Estados Unidos desde os anos 1990. Ela é responsável pela proposição e direção do programa de pós-graduação em Escrita Criativa, vinculado ao Departamento de Estudos Hispânicos da Universidade de Houston. Praticando o que tem sido chamado por escrita documental, em que o interesse em dar a ver os documentos de investigação supera a discussão sobre a tensão entre ficcional e não-ficcional, algumas de suas obras mais conhecidas são Habia mucha neblina o humo o no sé qué (2016), sobre o escritor mexicano Juan Rulfo; Nadie me verá llorar (1999) e La Castañeda (2010), respectivamente um romance e um relato histórico sobre um hospital psiquiátrico no México, tema de sua tese de doutorado; e Andamos perras, andamos diablas (2021), reedição de seu primeiro livro de contos, La guerra no importa (1991), em que discute a temática do feminicídio. Sua obra ficcional mais recente, El invencible verano de Liliana (2021), adentra e dá a ver os documentos de investigação sobre o feminicídio de sua irmã mais nova. Sua obra é escrita majoritariamente em espanhol e aborda questões relacionadas ao contexto mexicano, sendo marcada por contos, trabalhos investigativos, poesia, romances e ensaios críticos. Estaremos interessados aqui por sua publicação ensaística Los muertos indóciles. Necroescrituras y desapropiación (2019), na qual a escritora defende as noções de “necroescritas” e de “desapropriação” e em que articula uma variedade de noções advindas do campo intelectual francês, os deslocando para seu próprio contexto crítico-literário. Nosso foco estará sobretudo direcionado aos três primeiros ensaios da obra, nos quais a autora atualiza para seu campo de discussão noções como por exemplo “a morte do autor” (Roland Barthes), “a função autor” (Michel Foucault) e “a comunidade inoperada” (Jean-Luc Nancy). Buscaremos mostrar como Rivera Garza estabelece este contato e como ele é produtivo para seu pensamento crítico.
Uma ascese perversa: uma leitura barthesiana de O caderno rosa de Lori Lamby (1990), de Hilda Hilst
Authors: Miotto Flávia Herédia 
Published: October 2023

Este artigo propõe uma leitura de O caderno rosa de Lori Lamby (1990), por meio das noções de texto de prazer e texto de gozo, presentes na obra O prazer do texto (1973), de Roland Barthes. A hipótese principal trabalhada aqui, arregimentada pela fortuna crítica de Hilst (Rosenfeld, Muzart, Moraes, Pécora, Hansen, Silva, entre outros) é a de que a obra hilstiana em questão pode ser lida enquanto um texto de gozo, já que produz uma fenda, uma ruptura, uma transgressão em relação à ordem social. Há também, neste artigo, uma proposta de leitura da obra em questão enquanto um texto de prazer. Além dessas proposições de leitura, uma discussão sobre a figura do leitor e sua função no processo de atribuição de sentidos ao texto literário é realizada e, para tal, autores como Barthes, Perrone-Moisés e Culler são convocados ao debate. Por fim, algumas apreciações sobre O caderno rosa de Lori Lamby (1990) presentes em sites como Amazon e Goodreads são analisadas, de maneira a observar a recepção atual dessa obra por leitores “comuns”. Este artigo, portanto, em consonância com a chamada “Travessias da crítica na América Latina” tem a intenção de explorar os ecos dos textos barthesianos nas obras literárias latino-americanas e em suas recepções, contribuindo com os estudos de Barthes e Hilst no Brasil, revisitando seus textos e suscitando novas (e plurais) leituras em torno dessas produções.
Human Plaque Myofibroblasts to Study Mechanisms of Atherosclerosis
Authors: Buono Michele F. , Benavente Ernest Diez , Slenders Lotte , Methorst Daisey , Tessels Daniëlle , Mili Eloi , Finger Roxy , Kapteijn Daniek , Daniels Mark , van den Dungen Noortje A. M. , Calis Jorg J. A. , Mol Barend M. , de Borst Gert J. , de Kleijn Dominique P. V. , Pasterkamp Gerard , den Ruijter Hester M. , Mokry Michal 
Published: October 2023

Background
Plaque myofibroblasts are critical players in the initiation and advancement of atherosclerotic disease. They are involved in the production of extracellular matrix, the formation of the fibrous cap, and the underlying lipidic core via modulation processes in response to different environmental cues. Despite clear phenotypic differences between myofibroblast cells and healthy vascular smooth muscle cells, smooth muscle cells are still widely used as a cellular model in atherosclerotic research.

Methods and Results

Here, we present a conditioned outgrowth method to isolate and culture myofibroblast cells from plaques. We obtained these cells from 27 donors (24 carotid and 3 femoral endarterectomies). We show that they keep their proliferative capacity for 8 passages, are transcriptionally stable, retain donor‐specific gene expression programs, and express extracellular matrix proteins (
FN1
,
COL1A1
, and
DCN
) and smooth muscle cell markers (
ACTA2
,
MYH11
, and
CNN1
). Single‐cell transcriptomics reveals that the cells in culture closely resemble the plaque myofibroblasts. Chromatin immunoprecipitation sequencing shows the presence of histone H3 lysine 4 dimethylation at the
MYH11
promoter, pointing to their smooth muscle cell origin. Finally, we demonstrated that plaque myofibroblasts can be efficiently transduced (>97%) and are capable of taking up oxidized low‐density lipoprotein and undergoing calcification.

Conclusions
In conclusion, we present a method to isolate and culture cells that retain plaque myofibroblast phenotypical and functional capabilities, making them a suitable in vitro model for studying selected mechanisms of atherosclerosis.
Ticagrelor Versus Clopidogrel in Minor Stroke or Transient Ischemic Attack With Intracranial Artery Stenosis: A Post Hoc Analysis of CHANCE‐2
Authors: Wang Chunjuan , Jia Weili , Jing Jing , Meng Xia , Wang Anxin , Xu Qin , Zhang Xinmiao , Pan Yuesong , Xie Xuewei , Johnston S. Claiborne , Bath Philip M. , Lin Jinxi , Jiang Yong , Li Hao , Wang Yilong , Zhao Xingquan , Liu Liping , Li Zixiao , Wang Yongjun ,   for the CHANCE‐2 Investigators
Published: October 2023

Background
This study aimed to investigate the efficacy and safety of ticagrelor–aspirin versus clopidogrel–aspirin in Chinese patients by the presence and clinical presentation of intracranial artery stenosis (ICAS) using randomized trial data from the CHANCE‐2 (Clopidogrel in High‐Risk Patients With Acute Nondisabling Cerebrovascular Events‐II) trial.

Methods and Results

A total of 6412 patients with minor stroke or transient ischemic attack who carried
CYP2C19
loss‐of‐function alleles were randomized to either the ticagrelor–aspirin or clopidogrel–aspirin group. Patients without imaging of the intracranial artery were excluded from the nonprespecified subgroup analysis of CHANCE‐2. All patients included were classified into the following groups: without ICAS, symptomatic ICAS, or asymptomatic ICAS. The primary efficacy outcome was new strokes within 90 days. There were 5893 patients (median age, 64.8 years; 33.9% women) included, and 172 (4.9%), 171 (10.5%), and 57 (7.7%) cases of new strokes occurred within 90 days in the without ICAS, with symptomatic ICAS, and with asymptomatic ICAS groups, respectively. Ticagrelor–aspirin was associated with reduced risk of new stroke in patients without ICAS (62 [3.5%] versus 110 [6.3%]; hazard ratio [HR], 0.57 [95% CI, 0.41–0.78]) but not in those with symptomatic ICAS (HR, 0.77 [95% CI, 0.56–1.05]) or in those with asymptomatic ICAS (HR, 0.77 [95% CI, 0.43–1.38]) compared with clopidogrel–aspirin (
P
for interaction=0.14). There were no significant differences in the proportion of severe or moderate bleeding events among different ICAS groups.

Conclusions
Patients without ICAS received a significantly greater benefit from ticagrelor–aspirin than clopidogrel–aspirin after minor ischemic stroke or transient ischemic attack, and there was no statistically significant difference between treatments in patients with symptomatic ICAS or asymptomatic ICAS.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04078737.
First record of two cylindrical crab species of the genus Ixa (Decapoda, Brachyura, Leucosiidae) from the eastern Arabian Sea, with a key to the species of Ixa recorded from the Indian coast
Authors: Sureandiran B. , Dave T. H. , Suyani N. K. , Karuppasamy K. , Vidhya V. 
Published: October 2023

Abstract
Two cylindrical crabs, Ixa cylindrus (Fabricius, 1777) and Ixa edwardsii Lucas, 1858 are herein recorded for the first time from the coastal waters of the eastern Arabian Sea. Both species were collected from the bycatch landing of the commercial demersal trawlers operated along the Gujarat coastal region, northwest coast of India, between 20 and 80 m depth. Both species have been recorded from the Bay of Bengal on the east coast of India, but there is no detailed information available on their taxonomic identification and global distributional records.
Population Exposure to Compound Precipitation–Temperature Extremes in the Past and Future Climate across India
Authors: Dash Subhasmita , Maity Rajib , Kunstmann Harald 
Published: October 2023

Abstract
This study explores the population exposure to an increasing number of hydroclimatic extreme events owing to the warming climate. It is well agreed that the extreme events are increasing in terms of frequency as well as intensity due to climate change and that the exposure to compound extreme events (concurrent occurrence of two or more extreme phenomena) affects population, ecosystems, and a variety of socioeconomic aspects more adversely. Specifically, the compound precipitation–temperature extremes (hot-dry and hot-wet) are considered, and the entire Indian mainland is regarded as the study region that spans over a wide variety of climatic regimes and wide variation of population density. The developed copula-based statistical method evaluates the change in population exposure to the compound extremes across the past (1981–2020) and future (near future: 2021–60 and far future: 2061–2100) due to climate change. The results indicate an increase of more than 10 million person-year exposure from the compound extremes across many regions of the country, considering both near and far future periods. Densely populated regions have experienced more significant changes in hot-wet extremes as compared with the hot-dry extremes in the past, and the same is projected to continue in the future. The increase is as much as sixfold in many parts of the country, including the Indo-Gangetic Plain and southernmost coastal regions, identified as the future hotspots with the maximum increase in exposure under all the projected warming and population scenarios. The study helps to identify the regions that may need greater attention based on the risks of population exposure to compound extremes in a warmer future.

Significance Statement
How is the growing population being affected now, and in the future, how will it be affected due to climate change induced compound extreme events? This study explores this societal consequence in terms of population exposure for the most populous country, India. An increase of more than 10 million person-year exposure from the precipitation–temperature compound extremes across many regions is indicated. Densely populated regions are expected to experience enhanced population exposure to hot-wet extremes as compared with the hot-dry extremes. Furthermore, the maximum increase in population exposure to compound extremes is expected across the Indo-Gangetic Plain and southern coastal regions of India. The outcome of the study will be helpful for adopting socioeconomic decisions toward the welfare of society.
Safety of Patients with Renal Artery Aneurysm to Proceed with Living Donation
Authors: Meshkin Dana , Kann Rachel J. , Crane Andrew C. , Wijkstrom Martin , Gunabushanam Vik , Molinari Michele , Ganoza Armando , Tevar Amit D. 
Published: October 2023

Background Renal artery aneurysm (RAA) is a rare condition that involves dilation of all layers of the arterial wall of the renal artery. The risk of rupture is rare, but intervention is recommended for larger aneurysms. Surgical decision-making regarding live donor renal transplantation (LDRT) centers around safety for the living donor, and laterality of the donated kidney is based on providing the donor with the best longevity pertaining to the remaining kidney. We looked to review our long-term outcomes surrounding live donor transplants from donors with RAA with ex vivo resection and reconstruction prior to implantation. Methods A retrospective review was done of all laparoscopic live donor transplant nephrectomies with ex vivo aneurysm resection, reconstruction, and implantation at a single center. Results Three pairs of patients underwent successful laparoscopic donor nephrectomy, RAA resection, reconstruction, and transplantation of kidney. 2 males and 1 female ages 47 to 58 years of age underwent transplantation. The donors at 5 years of follow-up were noted to be functioning appropriately with no long-term sequelae of their donation and a mean remanent kidney function of 63 mL/min. Discussion For potential live donors with asymptomatic, unilateral renal artery aneurysm and no systemic disease, live donation with ex vivo resection and reconstruction can be performed with excellent long-term donor and recipient outcomes.
“Drum Tower Hospital” strategy for acute type A aortic dissection with coma
Authors: Wang Ya-peng , Lu Li-chong , Li Shu-chun , Li Li , Jiang Yi , Cheng Yong-qing , Ge Min , Chen Yang , Wang Dong-jin 
Published: October 2023

Overview Acute type A aortic dissection (ATAAD) with persistent coma is a life-threatening condition associated with high mortality and poor neurological outcomes. The optimal timing for surgical intervention in these patients remains uncertain, and many patients are not eligible for surgery due to their poor prognosis. Description In this case, a 53-year-old man with hypertension presented to the emergency department in a coma that had lasted for 9 hours. The patient was diagnosed with ATAAD and underwent the “Drum Tower Hospital” strategy, which involved preoperative assessments, including computed tomography angiography (CTA) and quantitative electroencephalogram (qEEG) monitoring. Surgical interventions, such as emergency stenting and aortic replacement, were performed to restore blood flow and repair the aorta. Postoperative monitoring, including qEEG, showed improvements in brain function. Despite the patient experiencing hemiplegia and a neurological deficit, the “Drum Tower Hospital” strategy, guided by comprehensive brain assessments, showed promise in managing ATAAD with coma. However, further research is needed to establish effective treatment strategies for these patients. Overall, ATAAD with persistent coma is a critical condition with limited treatment options. The “Drum Tower Hospital” strategy, supported by multimodal brain assessment, offers a potential approach to improve outcomes in these patients.
Time to level up: A systematic review of interventions aiming to reduce stigma toward autistic people
Authors: Kim So Yoon , Song Da-Yea , Bottema-Beutel Kristen , Gillespie-Lynch Kristen 
Published: October 2023

This systematic review examined 26 studies that implemented interventions to reduce stigma toward autistic people; the intervention recipients were primarily non-autistic people. Participants in the included studies were primarily White K-12 or undergraduate students. Most studies utilized one-time video or computer-based instruction, and more recent interventions tended to utilize online platforms. Studies varied in several respects: whether an autistic person was involved in the development and/or delivery of interventions, the intervention content, and the types and internal consistencies of the outcome variables. Risks of bias were prevalent. Masked outcome variables were used infrequently, and investigators were usually aware of group allocation. Among randomized controlled trials, the randomization processes were not sufficiently described, and non-randomized studies of interventions frequently did not account for confounding factors that could explain changes in stigma. Many non-randomized studies of interventions made unwarranted, causal claims about the intervention effectiveness on stigma reduction, and most studies did not sufficiently address limitations related to study design and risk of bias. The recommended areas of improvement include identifying active ingredients of interventions, measuring reliable changes in behaviors and attitudes, and targeting structural stigma. In addition, more robust procedures such as randomizing participants, using masked variables, and controlling baseline differences should be utilized. Lay abstract How non-autistic people think about autistic people impacts autistic people negatively. Many studies developed trainings to reduce autism stigma. The existing trainings vary a lot in terms of study design, content, and reported effectiveness. This means that a review studying how the studies have been conducted is needed. We also looked at the quality of these studies. We collected and studied 26 studies that tried to reduce stigma toward autistic people. The studies often targeted White K-12 students and college students. Most trainings were implemented once. Trainings frequently used video or computer. Especially, recent studies tended to use online platforms. The study quality was poor for most studies. Some studies made inaccurate claims about the intervention effectiveness. Studies did not sufficiently address study limitations. Future trainings should aim to figure out why and how interventions work. How intervention changes people’s behavior and thoughts should be studied. Researchers should study whether the training can change the societal stigma. Also, researchers should use a better study design.
Resident Perceptions of Virtual Reality Versus Dry Lab Simulation for Advanced Shoulder Arthroscopy Resident Training
Authors: Rivera Jessica C. , Johnson Anthony E. , Burns Travis C. , Roach Christopher J. 
Published: October 2023

Introduction Surgical training using simulation can fill gaps in traditional surgical residency learning. We hypothesize that arthroscopy training conducted on a virtual reality simulator will be preferred by orthopaedic surgery residents over a traditional dry lab simulation model. Methods 38 orthopaedic surgery residents at a single U.S. residency program were randomized to train for a shoulder arthroscopy procedure using either a virtual reality simulator or a table-top dry lab simulator. Training and learning preferences were then asked of the resident participants. Results Junior residents were likely to report training preference for the virtual reality simulator compared to senior residents [15/24 (62.5%) v. 8/14 (57.1%); P = .043]. Simulator preference was not influenced by subspecialty interest, prior arthroscopy experience, or simulator experience. Virtual reality simulation was associated with positive attitude towards arthroscopy and high chance of reporting learning gains on general arthroscopic understanding. Senior residents were 4.7 times more likely than juniors to report learning gains via staff discussion pre- and post-operatively. A majority of residents [34/38 (89.5%)] reported, however, wanting more simulation for training surgical skills. Conclusion Simulation is a desired and potentially valuable adjunct to training orthopaedic residents in arthroscopy. Training needs do evolve; and junior arthroscopists may benefit more from virtual reality platforms for general skills. Senior residents preferred dry lab simulation, possibly because it allowed for handling of actual instruments and implants.