bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Should We Do to Prevent Zoonoses with Pandemic Potential?
Authors: Deckers Jan 
Published: November 2023

Abstract
The majority of new infectious diseases that affect human beings are zoonoses. Zoonotic pressure is increasing for various reasons. These include: 1) the growth of the human population; 2) the growing concentration of human beings; 3) the growing mobility of the human population; 4) the rapid growth in the human usage of nonhuman animals; 5) the increasing intensification of the farm animal sector; 6) increasing ecological degradation, and 7) the lack of political will to address the previous six factors. These factors and the interplay between them create perfect storm conditions for the emergence of zoonoses with pandemic potential. What compounds the problem is a lack of moral theory on how to prevent zoonoses and associated pandemics. This article aims to address this gap by drawing on interdisciplinary work on zoonotic and pandemic prevention.
Southeastward Extension of the Aleutian Low Favors Long Decaying El Niño Events
Authors: Chen Wei 
Published: November 2023

Abstract
El Niño can be categorized into long and short decaying cases in terms of the lengths of decaying phases. We find that the difference between long and short decaying El Niño emerges as early as the decaying spring, rather than the decaying summer mentioned in previous studies. Observational evidence suggests that this difference corresponds to the different positions of the spring Aleutian low (AL). Further analysis using 15 Coupled Model Intercomparison Project phase 6 (CMIP6) model simulations suggests that the AL that extends southeastward into the northeastern subtropical Pacific contributes to the long decaying El Niño. The northeastern subtropical Pacific AL, with an anomalous southwesterly on the southeast edge, is associated with warming in situ, which further induces cyclonic circulation anomalies over the eastern tropical Pacific as Gill’s response. The anomalous westerly at the equator along the southern side of the cyclonic circulation anomalies is related to positive SST anomalies over the central and eastern tropical Pacific and therefore the persistence of El Niño in the decaying spring. On the other hand, the AL restricted to the North Pacific contributes to anticyclonic circulation anomalies over the central Pacific and favors the decline of El Niño through the seasonal footprint mechanism. Moreover, the models that reproduce many more long (short) decaying El Niño cases tend to simulate the AL southeastward extension (restriction over the North Pacific) during the El Niño decaying spring. The results imply that the AL position in the El Niño decaying spring could be a precursor to the length of El Niño decaying phase.

Significance Statement
El Niño events can be classified into long and short decaying cases with regard to the different lengths of decaying phases. We find that the difference between the two types of El Niño appears as early as the decaying spring, rather than the decaying summer noticed in previous studies. We highlight that this difference is due to the different positions of the spring Aleutian low (AL). Particularly, the AL that extends southeastward into the northeastern subtropical Pacific is associated with warming over the central and eastern tropical Pacific and contributes to the persistence of El Niño in the decaying spring. The results indicate that locations of the spring AL should be paid attention to when considering the decaying phase of El Niño.
The Implications of Readmission on Cost and Patient Outcomes Following Distal Pancreatectomy and Splenectomy
Authors: Ross Sharona B. , Doan Amy , Sucandy Iswanto , Christodoulou Maria , Pattilachan Tara M. , Crespo Kaitlyn L. , Rosemurgy Alexander S. 
Published: November 2023

Background Robotic platform usage for distal pancreatectomy and splenectomy has grown exponentially in recent years. This study aims to identify the impact of readmission following robotic distal pancreatectomy and splenectomy and to analyze the financial implications of these readmissions. Methods We prospectively followed 137 patients after robotic distal pancreatectomy and splenectomy. Readmission was defined as rehospitalization within 30 days post-discharge. Total cost incorporated initial and readmission hospital costs, when applicable. Outcomes were analyzed using chi-square/Fisher’s exact test and Student’s t test. Data are presented as median (mean ± SD). Results Of 137 patients, 20 (14%) were readmitted. Readmitted patients were 67 (66 ± 10.3) years old and had a BMI of 30 (30 ± 7.0) kg/m2; 9 (45%) had previous abdominal operations. Non-readmitted patients were 67 (62 ± 14.7) years old and had a BMI of 28 (28 ± 5.7) kg/m2; 37 (32%) had previous abdominal operations ( P = NS, for all). Readmitted patients vs non-readmitted patients had operative durations of 327 (363 ± 179.1) vs 251 (293 ± 176.4) minutes ( P = .10), estimated blood loss (EBL) of 90 (159 ± 214.6) vs 100 (244 ± 559.4) mL ( P = .50), and tumor diameter of 3 (4 ± 2.0) vs 3 (4 ± 2.9) cm ( P = 1.00). Initial length of stay (LOS) for readmitted patients vs patients who were not readmitted was 5 (5 ± 2.7) vs 4 (5 ± 3.0) days ( P = 1.00); total hospital cost of those readmitted, including both admissions, was $29,095 (32,324 ± 20,227.38) vs $24,663 (25,075 ± 10,786.45) ( P = .018) for those not readmitted. Discussion Despite a similar perioperative course, readmissions were associated with increased costs. We propose thorough consideration before readmission and increased patient education initiatives will reduce readmissions after robotic distal pancreatectomy and splenectomy.
The role of the local retail environment in the tobacco-purchasing behaviour of underage adolescents in Amsterdam
Authors: Peeters Denise A M , van Deelen Tessa R D , Kunst Anton E , van den Putte Bas , Kuipers Mirte A G 
Published: November 2023

Objective: Despite a nationwide ban on tobacco sales to people under 18 years of age, adolescents can still buy tobacco products in Amsterdam. This study aimed to understand the influence of the retail environment in adolescents’ activity spaces on their tobacco-purchasing behaviour. Method: Interviews were conducted with 13 adolescents (aged 14–19 years) who went to school in Amsterdam and had ever bought tobacco products. Questions were based on the capability, opportunity, motivation, behaviour (COM-B) model. City maps showing all tobacco outlets were used to visualise respondents’ activity spaces and purchasing areas. Transcripts were analysed thematically. Results: Adolescents preferred purchasing tobacco at shops where they had successfully purchased it before, instead of going to just any shop close by. They purchased tobacco products mostly in small shops. Supermarkets were avoided, as employees complied with age-verification procedures. The city centre provided easy access because the density of small shops was high. In adolescents’ residential area, acquaintances behind the counter might facilitate tobacco purchase, while it was a barrier for minors who secretly smoked. At school, adolescents developed a collective knowledge of shops that sold tobacco products to minors either near school or further away. Tobacco was also bought on the black market because it was cheaper or because it was possible to buy specific products (e.g. snus). Conclusion: Tobacco purchasing by minors is less about the proximity and more about which stores in their activity spaces sell tobacco products to minors. Policies should therefore be aimed at the enforcement of age limits and reducing the number of small shops selling tobacco.
Teachers’ perspectives on the EU Fruit and Vegetable Scheme implementation in Italy
Authors: Vitali Veronica , Tiboldo Giulia , Castellari Elena , Meshkovska Biljana 
Published: November 2023

Objective: School-based fruit and vegetable provision programmes can improve children’s eating patterns and health by ensuring access to fruit and vegetables and providing nutrition education. However, the effectiveness of these programmes may be significantly affected by the implementation quality. The objective of this study was to identify barriers and facilitators to the implementation of the EU School Fruit and Vegetables Scheme according to Italian teachers’ perspective. Design, Setting, and Method: We carried out semi-structured interviews with teachers in two elementary schools in Italy that had participated in the EU School Fruit and Vegetables Scheme for several years. The interview protocol was based on domains, constructs and sub-constructs from the Consolidated Framework for Implementation Research (CFIR). Qualitative data from the interviews were coded deductively using the CFIR to identify the main barriers and facilitators to implementing the EU School Fruit and Vegetables Scheme. Results: Among the main facilitators of implementation of the EU School Fruit and Vegetables Scheme were the quality and variety of the products, as well as the educational intentions behind the scheme, and teachers’ overall level of engagement. Barriers were to be found in lack of teacher training, an absence of accompanying measures, limited knowledge about a healthy diet, the low involvement of parents, and finally, problems with product delivery. Conclusions: Providing more comprehensive teacher education and training and extending access to accompanying measures may improve the EU School Fruit and Vegetables Scheme’s implementation quality and effectiveness. Moreover, allowing greater flexibility in between suppliers and accounting for each geographic area’s unique character are crucial to overcoming the delivery problems that currently act as barriers to the implementation of the scheme.
The Role of State and Trait Self-Control on the Sustained Attention to Response Task
Authors: Harwood Amanda E. , Satterfield Kelly , Helton William S. , McKnight Patrick E. , Shaw Tyler H. 
Published: November 2023

Objective This study aimed to assess the plausibility of self-control depletion, or ego-depletion, as the underlying cognitive resource responsible for performance decrements on the sustained attention to response task. Background Researchers suggested that self-control is a limited cognitive resource used to complete a myriad of processes, including sustained attention. Past research showed that trait self-control affects some sustained attention tasks. However, little research has investigated the effect of self-control as a limited cognitive resource that varies over time (i.e., as a state-dependent variable). Methods This experiment investigated the effect of self-control (trait and state) on a sustained motor-inhibition task (e.g., sustained attention to response task; SART). State self-control was manipulated using a between-subjects design—participants in the experimental condition completed a task designed to deplete state self-control prior to performing the SART while the control condition completed a modified version that did not deplete self-control. Results Trait self-control predicted performance on the SART, but the depletion task (state self-control) had no detectable effect. Conclusion Given the evidence, it is unlikely that state self-control plays a causal role in performance decrements in the SART, but there appears to be some association between performance on the SART and trait self-control. Application Trait self-control ought to be considered in future work for personnel selection in real-world tasks that the SART models such as long-distance driving, air traffic control, and TSA operations.
HMG co-reductase expression and response to intravesical Bacillus Calmette-Guérin in patients with high grade non-muscle invasive urinary bladder cancer receiving statins
Authors: Krishnan Jamie , Symington Andrew , Kernohan Neil , Bray Suan , Robertson Allison , Nabi Ghulam 
Published: November 2023

Background Cardiovascular disease affects over 7 million people in the UK and statins are often prescribed to mitigate cardiovascular risks. The effect of statins on a number of cancers is debated and their effect on Bacillus Calmette-Guérin (BCG) responsiveness in non-muscle invasive urinary bladder cancer (NMIBC) is not fully understood. Aims This study aims to explore the difference in HMG Co-A reductase (HMGCR) expression in NMIBC on immunochemistry in BCG responders and non-responders while on statins. Method Three hundred and thirty-two cases of intravesical BCG treatment for high-risk NMIBC between November 2003 and December 2017 were identified. Patients taking statins for at least 12 months before the diagnosis of NIMBC and with a follow-up of at least 5 years were included. They were divided into BCG responders and non-responders. Tumour tissue from these patients was immunohistochemically stained and quantitative image analysis carried out to assess and compare HMGCR expression in the groups. Results & Conclusion This study showed a differential expression of HMGCR in responders vs. non-responders to BCG for high-risk NMIBC on statins. This data should form the basis of a further research and multi-centre study in a larger cohort, using HMGCR as a biomarker of response in patients on statins.
Determinants of Performance in Professional Soccer Players at 2 and 5 Years After ACL Reconstruction
Authors: Pinheiro Vítor Hugo , Borque Kyle A. , Laughlin Mitzi S. , Jones Mary , Balendra Ganesh , Kent Madison R. , Ajgaonkar Ryan , Williams Andy 
Published: November 2023

Background: A number of studies have investigated return to play after anterior cruciate ligament reconstruction (ACLR) in professional soccer players, but it is unclear which factors are associated with a return to the preinjury performance and ability to play over time. Purpose: To identify factors that contribute to a professional soccer player's return to preinjury performance after ACLR, as well as to report their playing performance at 2 and 5 years after ACLR compared with their preinjury performance. Study Design: Case-control study; Level of evidence, 3. Methods: A consecutive cohort of professional soccer players undergoing primary ACLR were analyzed between 2005 and 2019. A minimum 2-year follow-up was required. The effect of patient, surgical, and postoperative factors on performance rates, defined as a combination of league level and playing time, was evaluated with univariate and multivariate logistic regression models. Results: A total of 200 male professional soccer players were included. When combining league level and playing time, 30% of athletes returned to their preinjury performance at 2 years and 22% at 5 years. However, 53% of athletes returned to their preinjury performance for at least 1 season by year 5. At 2 years, a chondral lesion of grade 3 or 4 decreased the odds of return to preinjury performance (odds ratio [OR], 0.37; P = .010). Athletes receiving an ACLR with the addition of a lateral extra-articular tenodesis procedure were 2.42 times more likely to return to preinjury performance at 2 years than athletes with ACLR alone ( P = .004). By 5 years after ACLR, athletes aged ≥25 years at the time of reconstruction were 3 times less likely to be performing at their preinjury performance (OR, 0.32; P < .001), and those with a grade ≥3 chondral lesion were >2 times less likely to be performing at their preinjury performance (OR, 0.43; P = .033). Conclusion: The presence of >50% thickness chondral pathology, ACLR without lateral extra-articular tenodesis, and age >25 years at the time of surgery were all significant risk factors of worse performance rates after ACLR. Significant decreases in performance rates were noted at 2 and 5 years postoperatively.
The value of a three-microRNA panel in serum for prostate cancer screening
Authors: Lin Shengjie , Sun Chen , Li Rongkang , Lu Chong , Li Xinji , Wen Zhenyu , Ge Zhenjian , Chen Wenkang , Li Yingqi , Li Hang , Lai Yongqing 
Published: November 2023

Background Globally, prostate cancer is the second most common malignancy in males. Serum microRNAs (miRNAs) may function as non-invasive and innovative biomarkers for various cancers. Our study aimed to determine potential miRNAs for prostate cancer screening. Methods A three-stage study was accomplished to ascertain crucial miRNAs as markers. In the screening stage, we searched PubMed for aberrantly expressed miRNAs relevant to prostate cancer and selected them as candidate miRNAs. In training and validation stages, with serum specimens from 112 prostate cancer patients and 112 healthy controls, expressions of candidate miRNAs were identified through quantitative reverse transcription-polymerase chain reaction. The diagnostic capabilities of miRNAs were determined by receiver operating characteristic curves. Bioinformatic analysis was utilized to explore the function of the critical miRNAs. Results Expression of six serum miRNAs (miR-34b-3p, miR-556-5p, miR-200c-3p, miR-361-5p, miR-369-3p, miR-485-3p) were significantly altered in prostate cancer patients contrasted with healthy controls. The optimal combination of critical miRNAs is a three-miRNA panel (miR-34b-3p, miR-200c-3p, and miR-361-5p) with good diagnostic capability. FLRT2, KIAA1755, LDB3, and NTRK3 were identified as the potential genes targeted by the three-miRNA panel. Conclusions The three-miRNA panel may perform as an innovative and promising serum marker for prostate cancer screening.
Prevalence and Incidence Trends of Attention Deficit/Hyperactivity Disorder in Children and Youth Aged 1–24 Years in Ontario, Canada: A Validation Study of Health Administrative Data Algorithms: Tendances de la prévalence et de l’incidence du trouble de déficit de l’attention/hyperactivité chez les enfants et les jeunes âgés de 1 à 24 ans, en Ontario, Canada: une étude de validation des algorithmes de données administratives de santé
Authors: Butt Debra A. , Jaakkimainen Liisa , Tu Karen 
Published: November 2023

Objective To estimate prevalence and incidence rates over time in children and youth with attention deficit/hyperactivity disorder from the validation of population-based administrative data algorithms using family physicians’ electronic medical records as a reference standard. Methods A retrospective cohort study was conducted in Ontario, Canada to identify attention deficit/hyperactivity disorder among children and youth aged 1–24 years in health administrative data derived from case-finding algorithms using family physicians’ electronic medical records. Multiple administrative data algorithms identifying attention deficit/hyperactivity disorder cases were developed and tested from physician-diagnosis of attention deficit/hyperactivity disorder in the electronic medical record to determine their diagnostic accuracy. We calculated algorithm performance using sensitivity, specificity, and predictive values. The most optimal algorithm was used to estimate prevalence and incidence rates of attention deficit/hyperactivity disorder from 2014 to 2021 in Ontario. Results The optimal performing algorithm was “2 physician visits for attention deficit/hyperactivity disorder in 1 year or 1 attention deficit/hyperactivity disorder-specific prescription” with sensitivity: 83.2% (95% confidence interval [CI], 81.8% to 84.5%), specificity: 98.6% (95% CI, 98.5% to 98.7%), positive predictive value: 78.6% (95% CI, 77.1% to 80.0%) and negative predictive value: 98.9% (95% CI, 98.8% to 99.0%). From 2014, prevalence rates for attention deficit/hyperactivity disorder increased from 5.29 to 7.48 per 100 population in 2021 ( N = 281,785). Males had higher prevalence rates (7.49 to 9.59 per 100 population, 1.3-fold increase) than females (2.96–5.26 per 100 population, 1.8-fold increase) from 2014 to 2021. Incidence rates increased from 2014 (0.53 per 100 population) until 2018, decreased in 2020 then rose steeply in 2021 (0.89 per 100 population, N = 34,013). Males also had higher incidence rates than females from 2014 to 2020 with females surpassing males in 2021 (0.70–0.81 per 100 male population,1.2-fold increase versus 0.36–0.97 per 100 female population, 2.7-fold increase). Conclusions Attention deficit/hyperactivity disorder is increasing in prevalence. We developed an administrative data algorithm that can reliably identify children and youth with attention deficit/hyperactivity disorder with good diagnostic accuracy.
Appropriate usage of post-exposure prophylaxis-in-pocket for HIV prevention by individuals with low-frequency exposures
Authors: Clifford Rashotte Matthew , Yoong Deborah , Naccarato Mark , Pico Espinosa Oscar J , Fisher Karla , Bogoch Isaac I , Tan Darrell HS 
Published: November 2023

PEP-In-Pocket (Post-Exposure Prophylaxis-In-Pocket, or “PIP”) is a biobehavioural HIV prevention strategy wherein patients are proactively identified and given a prescription for HIV post-exposure prophylaxis (PEP) medications to self-initiate in case of high-risk exposures. We evaluated this strategy in a prospective observational study at two hospital-based clinics in Toronto, Canada. HIV-negative adults using PIP underwent chart review and completed quarterly electronic questionnaires over 12 months. The primary objective was to quantify appropriate PIP initiation, defined as starting PIP within 72 h of a high-risk exposure. Secondary objectives were to quantify HIV seroconversions, changes in sexual risk behaviour, sexual satisfaction, and satisfaction with the PIP strategy. From 11/2017 to 02/2020, 43 participants enrolled and completed ≥1 questionnaire. PIP was self-initiated on 27 occasions by 15 participants, of which 24 uses (89%) were appropriate, 2 were unnecessary, and 1 was for an unknown exposure. Chart review identified no inappropriate non-use. Over 32 person-years of testing follow-up, we observed zero HIV seroconversions. Sexual risk declined modestly over follow-up, with a HIRI-MSM (HIV Incidence Risk Index for MSM) change of −0.39 (95% CI = −0.58, −0.21 per 3 months, p < .001). Sexual satisfaction was stable over time. At 12 months, 31 (72%) remained on PIP, 8 (19%) had transitioned to pre-exposure prophylaxis and 4 (9%) were lost-to-follow-up. Among participants who remained on PIP and completed questionnaires at 12 months, 24/25 (96%) strongly/somewhat agreed that PIP decreased their anxiety about contracting HIV and 25/25 (100%) strongly/somewhat agreed that they would recommend PIP to a friend. PIP is a feasible HIV prevention strategy in carefully selected individuals at modest HIV risk.
Does Bankruptcy Reforms Enhance Firm Performances for Politically Connected Firms? Evidence from India
Authors: Ganguly Kousik , Mishra Ajay Kumar 
Published: November 2023

Using a sample of 1,953 listed firms on the National Stock Exchange from 2009 to 2021, we investigate whether politically connected firms alter their cash holding patterns following the Insolvency and Bankruptcy Code (IBC) reforms introduced in 2016. We also examine the impact of changes in a firm’s cash holdings on its performance. Results show that politically connected firms reduced their cash holdings following the implementation of IBC in 2016, as new reforms better protected creditors through strict enforcement rights. We also find that politically connected firms with large amounts of cash perform poorly in the post-IBC period compared to their nonconnected peers. The results are robust after excluding the COVID-19 period and controlling for firm size, leverage, and business group affiliations. JEL Codes: G32; G34; G38