bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of different levels of serum progesterone on day of frozen ET on clinical outcome
Authors: Hosseini Sedigheh , Salehpour Saghar , Borujeni Parisa Taherzadeh , Hajizadeh Nazanin 
Published: October 2023

Abstract
Background
Progesterone (P4) plays a critical role in a natural menstrual cycle. It is an essential hormone to have successful embryo implantation into the endometrium.

Objective
In the current study, we compared the clinical outcomes of patients with different levels of P4 on embryo transfer day and aimed to determine the optimum threshold for P4 in the luteal phase.

Material and methods
We performed a prospective cohort study on 100 patients who were referred to the Taleqani Infertility Treatment Institute to undergo frozen embryo transfer (FET). Endometrial preparation was programmed using an estrogen (E2) and progesterone supplement. FET was carried out 3 days after administration of the first dosage of progesterone. We measured serum progesterone levels on embryo transfer day. Clinical pregnancy was the main investigated outcome. We used a parametric receiver operating characteristic curve (ROC) to determine the best-cut points of P4 on embryo transfer day.

Results
Overall, the average endometrial thickness was 7.9 ± 0.2 mm. We observed no association between endometrial thickness and clinical pregnancy (P value = 0.719). The mean number of the transferred embryos in all investigated cycles was 1.5 ± 0.5, and 80.0% of the transferred embryos were high quality (high and medium level). The average progesterone level in cycles with clinical pregnancy was 17.2 ± 3.3 ng/mL. It was only 13.4 ± 9.4 in patients without clinical pregnancy. The observed difference was statistically significant (P value = 0.032). The estimated AUC for the drawn ROC curve was 0.71 indicating a high predictive value.

Conclusion
The current study demonstrated that high and low serum progesterone (P4) levels on embryo transfer day were associated with reduced clinical outcomes following blastocyst transfer during IVF/ICSI. However, more studies with large sizes are required in this regard.
The utility of volumetric MRI in assessment of volume changes in ventral diencephalon in autistic children
Authors: Esmaeel Tamer El Zaeem , Abdelghany Hosny Sayed , Mounir Samir Mohamed , Rasekh Ahmed Ibrahim , Mahmoud Hassan Ali Ahmed , Allam Mohammad Fouad Abdel Baki 
Published: October 2023

Abstract
Background
Autism spectrum disorder (ASD) is a neurobehavioural disorder, characterized by abnormal affiliative and socio-emotional responses which are generally regulated by certain neuropeptides in the hypothalamus (an anatomic component of the ventral diencephalon (VD)). The use of volumetric MRI for studying VD volume change could provide a novel approach for identification of structural brain changes in ASD; this could assist in understanding the pathophysiology of ASD and would reflect on treatment strategies. The aim of the current work was to investigate the role of MRI volumetric analysis of the ventral diencephalon in young children diagnosed with autism spectrum disorder.

Methods
Fifty children diagnosed with ASD underwent volumetric brain analysis, on a fully automated MRI brain volumetry system (volBrain), with voxel-based morphometry of various segmental structures of the brain including the VD, using vol2Brain 1.0 pipeline software analysis suite.

Results
There were 48 out of 50 children who demonstrated abnormal VD volume which was found below the normal limits compared with reference standard normalized volume. All cases were normocephalic demonstrating normal intra-cranial cavity volumes. Forty out of fifty cases showed increased total volume of grey matter, and eighteen out of fifty cases showed increased total volume of white matter. Regarding the amygdala and hippocampus, there were only two cases (4.0%) which showed slightly increased relative volume of the total amygdala, and two other cases (4.0%) demonstrated increased relative volume of the total hippocampus. Comparison between the autistic patients and normal references revealed a significant difference regarding the VD volume and total volume of grey matter, whereas no significant differences were found regarding the white matter amygdala and hippocampus.

Conclusions
Based on the consistent significant volume decrease in the ventral diencephalon in patients with childhood autism, this study concluded that volumetric MRI analysis could be useful for diagnosis of childhood spectrum disorder and could be utilized as a reliable screening method in the clinically vague cases. Further study with a larger sample size including more age groups is recommended for more validation of the results.
Emerging burdens of adolescent psychosocial health problems: a population-based study of 202 040 adolescents from 68 countries
Authors: Rahman Md Ashfikur , Kundu Satyajit , Christopher Enryka , Ahinkorah Bright Opoku , Okyere Joshua , Uddin Riaz , Mahumud Rashidul Alam 
Published: October 2023

Background
Psychosocial health problems are major public health burdens for adolescents. Identifying risk factors is essential to containing negative health implications.

Aims
This study aimed to estimate the burden of psychosocial health problems among adolescents, and identify potential risk and protective factors.

Method
We used the Global School-based Student Health Survey data from 68 countries across six World Health Organization regions. We computed the overall, national- and regional-level weighted estimates of the mean number of psychosocial health problems. Adjusted Poisson regression models examined the factors associated with psychosocial health problems.

Results
Our sample totalled 202 040 adolescents aged 11–17 years (mean age 14.6 [s.d. 1.18] years), composed of 95 589 (47.31%) boys and 104 191 (51.57%) girls (2260 (1.12%) missing answers). Samoa had the highest mean number of psychosocial health problems (mean 2.64 [s.d. 1.41]), and Niue had the lowest (mean 0.33 [s.d. 0.72]). In the pooled analysis, the following factors were associated with higher rates of psychosocial health problems in adolescents globally: ≥13 years of age, being female, experiencing food insecurity, experiencing physical violence, having been bullied, engagement in physical altercation, experiencing serious injury, missing school without parental permission, lack of parental support or monitoring, parents who were not understanding of their child's problems and high sedentary behaviour. Being female, food insecurity, bullying, physical attacks or serious injury were all significantly associated with higher rates of psychosocial health problems in each of the six regions separately.

Conclusions
The prevalence of psychosocial health problems is high among adolescents, although there are country-level variations. Health promotion strategies should consider the identified factors to promote adolescents’ health and well-being.
Free Medicine
Authors: Raengo Alessandra 
Published: October 2023

AbstractThinking along Ariel Brown's 2021 video history | alchemy | evolution, this introduction approaches “suspension” as a concept, hermeneutic, aesthetic practice, and ethics of intellectual praxis by focusing on the way it dovetails with the radical work the prefix ana- performs in Black studies and the way black aesthetic practices often hinge on anaoriginarity and anachronism as they seek to effect anarchitectural interventions in the languages and institution of artmaking.
Effect of Lifestyle on Reducing Risk Factors for Type 2 Diabetes among Arab Canadian Muslim Women: A Randomized Control Trial
Authors: HUSSIEN SHERIN , MCMANUS RUTH , PRAPAVESSIS HARRY , SOPPER MAGGIE M. , MOTTOLA MICHELLE F. 
Published: October 2023

ABSTRACT

Purpose
This study aimed to investigate whether modifiable risk factors for type 2 diabetes (T2D) can be reduced by an intensive healthy lifestyle intervention designed for Arab Muslim women of Middle Eastern descent (AWMD) who are at high risk for this disease. We hypothesized that among Canadian AWMD, the intervention would (a) reduce the identified health risk factors for T2D (body mass index [BMI], ≥30 kg·m−2; fasting blood glucose [FBG], ≥5.6 mmol·L−1; and waist circumference [WC], ≥80 cm); (b) improve anthropometric measurements; (c) improve lifestyle factors (physical activity level [steps per day] and dietary habits); and (d) improve cardiovascular fitness and reduce blood pressure.

Methods
After informed consent, 60 participants were randomized to either an exercise and nutrition group (ENG; n = 30) or a control group (CON; n = 30). ENG attended a women-only supervised exercise program that presented Arabic music and traditional Lebanese Dabka three times a week in a Mosque gym for 12 wk. A nutritionist was available 1 h·wk−1 for nutrition education. The CON followed their typical day.

Results
ENG and CON had similar increased risk profiles for diabetes at baseline. Large significant pre/posttreatment interaction effects were found for BMI, FBG, and WC with a reduced diabetes risk for ENG compared with CON for BMI (1,58) = 1184.8, P < 0.001), FBG (1,58) = 187.7, P < 0.001), and WC (1,58) = 326.4, P < 0.001). The ENG had significantly more participants reach postintervention target values (BMI: χ
2(1) = 16.48, P = 0.001; FBG: χ
2(1) = 52.26, P < 0.001; WC: χ
2(1) = 4.29, P = 0.038) compared with the CON. Adherence to the program was 100%.

Conclusions
Modifiable risk factors for T2D were reduced by using a culturally sensitive intervention program with high adherence through weight loss, regular exercise, and nutrition education.
Influence of Second-Generation Oral Contraceptives on Muscle Recovery after Repeated Resistance Exercise in Trained Females
Authors: OXFELDT MIKKEL , PEDERSEN ANTON B. , HØRMANN DANIEL , LIND JESPER H. , LARSEN EMIL B. , AAGAARD PER , HANSEN METTE 
Published: October 2023

ABSTRACT

Purpose
Oral contraceptives (OCs) are commonly used by female athletes, but their effects on skeletal muscle are still poorly understood. We investigated if physically trained females using second-generation OCs differed from nonusers of OCs in the recovery of muscle function and muscle damage markers after repeated resistance exercise sessions.

Methods
We recruited 20 trained second-generation OC users and 20 trained nonusers to perform three strenuous resistance exercise sessions. Before, and 3, 24, and 48 h after exercise, blood samples were collected, and participants were evaluated for muscle soreness, maximal isometric and isokinetic muscle strength, vertical jump height, Wingate power performance, leg press strength, and intermittent recovery capacity (yo-yo test). All participants were provided with an energy-macronutrient–balanced diet during the experimental period.

Results
After resistance exercise, maximal isometric and isokinetic muscle strength, rate of force development, vertical jump height, and Wingate peak and average power were reduced, whereas markers of muscle damage were increased in both groups (P < 0.05). OC users experienced a greater reduction in isokinetic strength 3, 24, and 48 h after exercise compared with nonusers of OCs (interaction: P < 0.05). No other interactions were observed.

Conclusions
We demonstrate that measures of muscle strength recovery after three strenuous resistance exercise sessions are comparable between trained females using second-generation OCs and nonusers of OCs. However, group differences were observed for isolated dynamic (isokinetic) muscle strength, suggesting a marginal benefit of not using OCs when accelerated recovery is needed.
Feasibility of Constant Work Rate Testing to Detect Exercise-Induced Laryngeal Obstruction
Authors: THOUGAARD JENS , PEDERSEN LARS , WALSTED EMIL 
Published: October 2023

ABSTRACT

Introduction
Exercise-induced laryngeal obstruction (EILO) is a condition in which laryngeal structures inappropriately obstruct the upper airway during exercise. The standard diagnostic test for EILO is the continuous laryngoscopy during exercise (CLE) test, usually performed with an incremental work rate protocol regardless of the nature of the triggering event. Typically, laryngeal obstruction occurs only briefly at the end of an incremental test, near peak work capacity. We aimed to investigate constant work rate (CWR) protocols for CLE testing to expand diagnostic test modalities and improve the understanding of EILO.

Methods
In this prospective, self-controlled feasibility study, 10 patients with EILO performed both an incremental and a CWR CLE test at 70%, 80%, and 90% of maximal exercise capacity. Laryngoscopic video data were recorded and compared, and we evaluated the ability of CWR to reproduce the symptoms and laryngeal obstruction seen in incremental testing.

Results
In 70%–90% of cases, CWR testing induced at least the same severity of obstruction as incremental testing and CLE scores remained comparable across test modalities. CWR at 70% allowed observation of laryngeal obstruction for a significantly longer duration than in incremental testing (158 s; 95% confidence interval, 25–291 s; P = 0.027). Dyspnea intensity appeared higher during CWR testing compared with incremental testing.

Conclusions
Submaximal CWR CLE testing is feasible and able to induce EILO equivalent to the standard incremental CLE test. This is the first step toward tailored CLE exercise protocols, and further studies are now needed to establish the utility of CWR in clinical and research settings.
Case Report: Incidental discovery of primary peritoneal psammocarcinoma
Authors: Helal Imen , Khanchel Fatma , Jouini Raja , Ben Thayer Maissa , Mbarki Chaouki , Bettaieb Hajer , Rebii Saber , Ben Ismail Imen , Ben Brahim Ehsen , Chedli-Debbiche Aschraf 
Published: October 2023

Psammocarcinoma is an uncommon subtype of low-grade serous carcinoma. It is characterized by the presence of extensive psammoma bodies and can have either an ovarian or peritoneal origin. To our knowledge fewer than 30 cases of primary peritoneal psammocarcinoma (PPP) have been reported in the English literature. We report a rare case of PPP in a 74-year-old female, discovered fortuitously within a laparotomy for gallbladder lithiasis. At laparotomy, multiple nodular implants involving the omentum, the peritoneum and a magma of intestinal loops in the right iliac fossa were noted. A biopsy from nodules was performed. Gross examination showed multiple nodules of different sizes in the fat tissue. Pathologic examination showed massive psammoma bodies representing more than 75% of the tumor. The final diagnosis was psammocarcinoma. Our patient was referred to the gynecologic department for further investigation and to ascertain whether the tumor arose from the ovaries or peritoneum. Hysterectomy, bilateral adnexectomy and omentectomy were performed. Macroscopic examination showed that both ovaries were intact having a normal size. No invasion of ovarian stroma was shown in microscopic examination. The patient died of SARS-CoV-2 (COVID-19) six days after the surgery. PPP is a rare type of low-grade serous carcinoma. The behavior of this tumor is unclear, and the treatment is not standardized because of its rarity and lack of long-term follow-up. More cases need to be studied for better understanding and improvement of the management protocols.
A procedure for estimating fundamental variability
Authors: Uhlig Steffen , Colson Bertrand , Gowik Petra 
Published: October 2023

Background: The question whether a given set of test items can be considered “identical” is often addressed in terms of the homogeneity of the test material from which said items were taken. However, for some types of matrices – in particular, for matrices consisting of minute separate particles, only some of which carry the analyte under consideration – even in the case of homogenous test material, an irreducible source of variability between test items may remain: the fundamental variability. Methods: In this paper, the concept of fundamental variability is explained, and procedures for reducing and characterizing it are described. Results: The proposed procedure allows both the detection and quantification of the fundamental variability. In addition, it is shown how fundamental variability cannot be identified in homogeneity testing according to Annex B.1.1 in ISO 13528. Conclusions: The fundamental variability can be brought under control by increasing sample size and by finer grinding of samples. Both of these measures are tantamount to increasing the average number of carrier particles per subsample. The procedure proposed in this paper for characterizing the fundamental variability requires a high number of individual analyses. It therefore makes practical sense to link the proposed procedure with suitable model assumptions in order to then arrive at an estimate of fundamental variability in routine applications with much less effort. The case of heterogenous samples lies beyond the scope of ISO 5725. The question whether irreducible sample heterogeneity should be considered an actual component of an analytical method’s precision has perhaps not yet received sufficient attention. One possible approach would be to distinguish method precision per se (laboratory bias and repeatability precision) from matrix heterogeneity, and to provide information regarding both. Certainly, if the fundamental variability is non-negligible, then it must be accounted for in any evaluation of measurement uncertainty.
Clinical profile of brain abscesses: ten-year retrospective single-center study
Authors: Adhikari Ganesh , Lamichhane Samit , Sapkota Aashish , Shrestha Ajit , Bhatt Nidhi , Raj Bastola Nimish 
Published: October 2023

Background: Brain abscess is a rare clinical entity of neurosurgery with poor outcomes. In this study, we aimed to develop clinical profiles of the cases of brain abscesses presented at Chitwan Medical College by reviewing hospital records. Methods: The hospital-based retrospective study includes 18 patients presented from April 2013 to April 2023 diagnosed with brain abscess. Data regarding their demographic profile and other factors were collected in well-structured proforma from hospital records, OT records, and ICU records of the neurosurgery department of Chitwan medical college teaching hospital. Data were analysed using SPSS software using frequencies, proportions, and means functions. Results: In our study, we reported 18 cases of brain abscess with a mean age of 24.6 years having male to female ratio of 3.5:1. Fever, headache, and focal neurological deficit (classic triad of brain abscess) were present in 16.67 % of the cases. The most common presenting complaint was fever in 61.1 % following headache in 50% of cases. The commonly involved part of the brain was temporal lobe 27.8%. Primary focus of lesion was identifiable in ten cases with CSOM being the most common focus in 44.4% of the case. Consciousness was clear (GCS = 15) in five patients (27.7%), mildly disturbed (GCS = 13 or 14) in 16.7% , moderately disturbed (GCS = 9-12) in 44.5%, and severely disturbed or comatose (GCS = 3-8) in 11.11% of patients. 72.2 % of the cases were managed by craniotomy and evacuation, 11.1% by burr hole and evacuation whereas 16.7% denied any form of treatment. Conclusion: The advancement of imaging techniques and the use of IV antibiotics has exponentially improved outcome of the brain abscesses. Furthermore, with CSOM being the most common contagious focus, multidisciplinary management of the cases with brain abscess will benefit the patient.
PERMA well-being and innovative work behaviour : A systematic literature review
Authors: Ibrahim Nor Fauziana , Mohamad Sharif Sabri , Saleh Hasan , Mat Hasan Nor Hasliza , Jayiddin Nur Faezah 
Published: October 2023

Background: The purpose of this research is to examine at how the literature measures the relationship between PERMA (positive emotion, engagement, relationships, meaning, and accomplishments) well-being and innovative work behaviour (IWB). Methods: This systematic literature review examines peer-reviewed English research papers published in 2012 that investigate the relationship between PERMA well-being and IWB. A total of 37 publications were discovered in 32 journals. Results: A total of 220 articles were initially retrieved from the database. 37 studies out of 220 satisfied the inclusion criteria and were thoroughly examined. Our findings present a comprehensive overview of the types of PERMA well-being related to IWB in different countries and industries. Literature-based research approaches are also discussed. Research methods from the previous literature are also discussed. Conclusions: This study is one of the first to conduct a systematic literature review (PRISMA) method on the relationship between PERMA well-being and IWB. This review suggests constructive future research directions.
Proton pump inhibitor (PPI) administration and Clostridioides difficile infection - is this a real clinical problem? A critical review of the literature
Authors: Głaz Aneta , Knop Kinga , Kochanowska Anna , Wach Damian , Piasecka Zuzanna , Wesołek Ewelina , Kasztelan-Szczerbińska Beata , Skrzydło-Radomańska Barbara 
Published: October 2023

Background: Proton pump inhibitors (PPIs) are widely used drugs that reduce gastric acid secretion. In recent years, there has been a gradual increase in their use. The safety of prolonged PPI therapy and the potential for cumulative side effects of these drugs raise legitimate concerns. An association between PPI administration and the risk of Clostridioides difficile infection has been suggested. The findings regarding this phenomenon require further unequivocal verification.
Material and methods: A review of publications obtained from the PubMed database and published between 2016-2023. Based on the keywords "proton pump inhibitor", "PPI" and "Clostridium", 132 articles were selected. Finally, 6 meta-analyses were included in the analysis.
Results: Studies conducted in recent years have shown a statistically significant increase in the risk of C. difficile infection in patients taking PPIs compared to those who avoid this therapy. The aforementioned relationship was observed in both adults and pediatric patients. One study proved that the risk remained high even up to 1 year after the end of treatment. The described relationship is still a matter of debate due to the fact that patients using antacids are usually elderly, have several comorbidities and a higher risk of developing C. difficile infection regardless of PPI use.
Conclusions: The relationship between the use of PPIs and the risk of developing C. difficile infection is still controversial, which justifies the need for continued clinical trials to objectively resolve this issue. PPIs exert high efficacy in the treatment of acid-dependent diseases, but due to the many ambiguities surrounding possible side effects, caution in their administration seems warranted, especially for long-term therapy in elderly patients with polypharmacy.