bluuebunny/crossref_metadata_2025_split huggingface dataset:
A film-based intervention to reduce child maltreatment among migrant and displaced families from Myanmar: Protocol of a pragmatic cluster randomized controlled trial
Authors: Sim Amanda , Jirapramukpitak Tawanchai , Eagling-Peche Stephanie , Lwin Khaing Zar , Melendez-Torres G. J. , Gonzalez Andrea , Oo Nway Nway , Castello Mitjans Ivet , Soan Mary , Punpuing Sureeporn , Lee Catherine , Chuenglertsiri Pattraporn , Moo Th’Blay , Puffer Eve 
Published: October 2023

Background
Child maltreatment is a global public health crisis with negative consequences for physical and mental health. Children in low- and middle-income countries (LMIC)–particularly those affected by poverty, armed conflict, and forced migration–may be at increased risk of maltreatment due to heightened parental distress and disruptions to social support networks. Parenting interventions have been shown to reduce the risk of child maltreatment as well as improve a range of caregiver and child outcomes, yet large-scale implementation remains limited in low-resource displacement settings. This study will examine the impact of an entertainment-education narrative film intervention on reducing physical and emotional abuse and increasing positive parenting among migrant and displaced families from Myanmar living in Thailand.

Method
The study is a pragmatic, superiority cluster randomized controlled trial with approximately 40 communities randomized to the intervention or treatment as usual arms in a 1:1 ratio. Participating families in the intervention arm will be invited to attend a community screening of the film intervention and a post-screening discussion, as well as receive a poster depicting key messages from the film. Primary outcomes are changes in physical abuse, emotional abuse, and positive parenting behaviour. Secondary outcomes include caregiver knowledge of positive parenting, caregiver attitudes towards harsh punishment, caregiver psychological distress, and family functioning. Outcomes will be assessed at 3 time points: baseline, 4 weeks post-intervention, and 4-month follow up. A mixed methods process evaluation will be embedded within the trial to assess intervention delivery, acceptability, perceived impacts, and potential mechanisms of change.

Discussion
To our knowledge, this study will be the first randomized controlled trial evaluation of a film-based intervention to reduce child maltreatment among migrant and displaced families in a LMIC. An integrated knowledge translation approach will inform uptake of study findings and application to potential scale up pending evaluation results.

Trial registration
The study was prospectively registered with the Thai Clinical Trials Registry on 22 February 2023 (TCTR20230222005).
Design, synthesis, and antiproliferative activity of novel 1,2,4-triazole-chalcone compounds
Authors: Li Jinjing , Fan Pingping , Liu Yuxiao , Zhao Yan , Shi Chengyang , Zhou Shujing , Qiu Hongbin 
Published: October 2023

Abstract
A series of novel 1,2,4-triazole-chalcone compounds 10a–10s were designed by molecular hybridization strategy and synthesized. The molecular structures of the novel chalcones were characterized by 1H-NMR, 13C-NMR, and HRMS. The anti-proliferative activities of the novel chalcones against four cancer cell lines in vitro were examined by MTT, four tumor cell lines including human colon cancer cell SW620, human non-small cell lung cancer cell A549, human cervical cancer cell HeLa, and human breast cancer cell MCF-7. Compound 10o showed certain selectivity to SW620 cell line, and its IC50 value was 21.55 μM. 10q had good anti-proliferative activity against A549 cells with an IC50 value of 25.58 μM.
Ionospheric TEC modeling using COSMIC-2 GNSS radio occultation and artificial neural networks over Egypt
Authors: Sherif Ahmed , Rabah Mostafa , Mousa Ashraf El-Kutb , Zaki Ahmed , Anwar Mohamed , Sedeek Ahmed 
Published: October 2023

Abstract
The ionospheric delay significantly impacts GNSS positioning accuracy. To address this, an Artificial Neural Network (ANN) was developed using the high-quality COSMIC-2 ionospheric profile dataset to predict the Total Electron Content (TEC). ANNs are adept at addressing both linear and nonlinear challenges. For this research, eight distinct ANNs were cultivated. These ANNs were designed with the following inputs Year, Month, Day, Hour, Latitude, and Longitude. Along with solar and geomagnetic parameters such as the F10.7 solar radio flux index, the Sunspot Number (SSN), the Kp index, and the ap index. The goal was to discern the most influential parameters on ionosphere prediction. After pinpointing these key parameters, an enhanced model utilizing a pioneering technique of a secondary ANN was employed with the main ANN to predict TEC values for events in 2023. The study’s findings indicate that solar parameters markedly enhance the model’s accuracy. Notably, the augmented model featuring a prelude secondary network achieved a stellar correlation coefficient of 0.99. Distributionally, 41 % of predictions aligned within the (−1≤ ΔTEC ≤1) TECU spectrum, 28 % nestled within the (1< ΔTEC ≤2) and (−2≤ ΔTEC <−1) TECU ambit, while a substantial 30 % spanned the broader (2< ΔTEC ≤5) and (−5≤ ΔTEC <−2) TECU range. In essence, this research underscores the potential of incorporating solar parameters and advanced neural network techniques to refine ionospheric delay predictions, thus boosting GNSS positioning precision.
Effect of vitrification on protein O-GlcNAcylation in mouse metaphase II oocytes
Authors: Zhang Kang , Lan Tianyang , Lin Feifei , Liu Ruichuan , He Qifu , Gao Feng , Wu Shenghui , Kang Jian , Li Hongmin , Quan Fusheng 
Published: October 2023

In brief
Oocyte vitrification leads to DNA hypomethylation, which results in defect in early embryo development. This study reveals that oocyte vitrification impairs the DNA methylation pattern by influencing protein O-GlcNAcylation.

Abstract
Oocyte vitrification leads to decreased DNA methylation levels, which impairs the quality and the developmental potential of oocytes. However, the underlying molecular mechanism still need to be further revealed. In this study, mouse metaphase II (M II) oocytes were frozen by vitrification technology, while fresh oocytes were used as the control group. The effect of oocyte vitrification on protein O-GlcNAcylation and its impact on the developmental potential of oocytes were elucidated. We found that the protein O-GlcNAcylation levels were significantly increased in vitrified oocytes. Increase of protein O-GlcNAcylation levels in control oocytes by PUGNAc (an O-GlcNAcase inhibitor) decreases blastocyst rate after parthenogenetic activation (20.82% in PUGNAc-treated group; 53.82% in control group, P  <  0.05). We also discovered that DNA methylation was disrupted in two-cell embryos derived from vitrified oocytes, resulting in decreased 5mC and increased 5hmC, showing similar phenotypes to that derived from PUGNAc-treated oocytes. In vitrified and PUGNAc-treated oocytes, O-GlcNAcylated TET3 was significantly increased. Notably, by inhibiting protein O-GlcNAcylation in vitrified oocytes using OSMI1 (an O-GlcNAc transferase inhibitor) we restored the DNA methylation in two-cell embryos and ameliorated the developmental defects in early embryo. Thus, elevated protein O-GlcNAcylation in vitrified oocytes is an essential contributor to their declining embryonic developmental potential. Modulation of protein O-GlcNAcylation improves the developmental potential of vitrified oocytes.
Protecting against moral injury among healthcare missionaries
Authors: Ritchie James , Toppe Michael , Lindberg Doug , Paltzer Jason 
Published: October 2023

As mentioned in the introduction of our study in this issue, Moral injury among healthcare missionaries: a qualitative study, the setting of cross-cultural medicine inherently produces moral injury. This moral injury occurs because different cultures have different deeply held values, and medical care intersects with some of the most emotionally and spiritually powerful values. Moral injury is one of the most common reasons for distress in healthcare missionaries, and the consequences can be severe and lifelong. This calls for adequate preparation, ongoing mentoring, institutional boundary-setting, and further research.
Effects of Fatigue Induced by the Running-Based Anaerobic Sprint Test on the Performance in Execution Time and Decision-Making in Technical-Tactical Actions in Soccer (Passing and Driving) in a Laboratory Situation
Authors: Calle-Jaramillo Guillermo Andrés , Gonzalez-Palacio Enoc Valentin , Rojas Jaramillo Andres , Gonzalez-Jurado Jose Antonio 
Published: October 2023

Study purpose. The running-based anaerobic sprint test (RAST) has been developed to assess anaerobic power and fatigue levels using a repeated sprint protocol. The aim of this research was to study the effect of fatigue induced by RAST on performance in execution time (ET) and decision-making (DMA) in technical-tactical actions in soccer in a laboratory situation.
Materials and methods. Quasi-experimental, longitudinal, pretest-posttest comparative study. Two groups of soccer players (n = 34) divided into a control group (n = 18) and an experimental group (n = 16) were evaluated twice at two different times.
Results. Taking into account the p-value, effect size and statistical power, there are differences before and after RAST in the variables Total Index (TI) and ET, and not in DMA. On the other hand, the control group remained stable at both times.
Conclusions. After the intervention, the experimental group showed a decrease in the figures of the ET and TI variables, but not in the DMA variable, in other words, the decisional time and motor time, components of the ET variable and essential at the time of rapid decision-making, increased in the posttest.
Pharmacognostic and Pharmacological Screening of Tamarindus indica Seed in Streptozotocin-Induced Diabetic Rats
Authors: Thanage Somnath R. , Deshmukh Vilas N. 
Published: October 2023

Tamarindus indica, commonly known as tamarind, is a versatile tropical tree that has been used for centuries in traditional medicine due to its numerous therapeutic properties. This study aimed to conduct a comprehensive pharmacognostic and pharmacological evaluation of Tamarindus indica seeds to ascertain their medicinal potential. The pharmacognostic evaluation involved macroscopic of the seeds. The seeds were observed for their morphology and phytochemical evaluation; various solvent extracts of Tamarindus indica seeds were prepared using increasing polarity solvents, including petroleum ether, chloroform, ethanol, ethyl acetate and water. The extracts were screened for the presence of secondary metabolites using standard qualitative tests. Quantitative estimation of leading phytoconstituents, such as alkaloids, flavonoids, phenolic compounds, saponins, tannins, and glycosides, was performed using established methods. In the present study, Ethanolic extract of seed of Tamarindus indica Linn. was found to have potentiated antidiabetic activity that reduces blood glycemic index in streptozotocin (STZ)-induced diabetic male rats. Supplementation of this Ethanolic extract by gavage at the dose of 80 mg/0.5 ml distilled water/100 g body weight per day in STZ-induced diabetic rats significantly lowered fasting blood sugar level after 7 days. Continuous treatment of this extract for 14 days resulted in no significant difference in this parameter from the control level. Moreover, this treatment significantly elevated liver and skeletal muscle glycogen content; in conclusion, this study's pharmacognostic evaluation provided valuable botanical information; the phytochemical analysis demonstrated that the seeds contain a diverse range of bioactive compounds, suggesting their potential medicinal value.
REPRESENTATION OF DIALECTISMS IN THE PROSE OF YURIY VYNNYCHUK: PHONETIC ELEMENTS
Authors: Druzhynets M. L. , Genova O. V. 
Published: October 2023

The article is devoted to the study of the Naddniester dialect units, in particular, to the study of their individual authorial specificity in the fiction. The purpose of the study is to substantiate the specifics of the Naddnistrian dialect units and their local phonetic features in the prose works of Yu. Vynnychuk. Objectives of the study: to highlight the specifics of the writer’s work with dialectal units; to characterize the phonetic features of the Naddnistrian dialect and its nomination; to form a corpus of Naddnistrian dialectal units used by the writer at the phonetic level; to identify and characterize the specifics of the representation of dialectal elements in the prose works of Yu. Vynnychuk at the phonetic level of the language structure. The object of the study is the language of Yuriy Vynnychuk’s prose works, which contain dialect elements. The subject of the study is the Naddnistrian lexical dialects (in particular, their phonetic features) in the works of Y. Vynnychuk. The source material is based on Yuriy Vynnychuk’s novels “Tango of Death”, “Malva Landa” and the collection of short stories “Windows of Frozen Time”.
The study of the factual material was conducted in the aspect of synchrony on the basis of the general scientific method of observation and description of linguistic phenomena. The methods of external and internal interpretation are applied. The specificity of the Naddnestrian linguistic elements is established by means of the comparative method, the method of contextual analysis allowed to fix the dialectal features at all language levels and to establish the meaning of a certain lexeme in a certain context.
The corpus of the Naddnestrian dialectal units used by the writer is formed and the phonetic units of the Naddnestrian dialect are distinguished (in the suffix -sk- the sound [s′] turns into [s]; cases of apocopy; the presence of alegroforms; alternation of [o] with [i] and [o] with zero sound; transition in unstressed position of [e] to [i]; assimilation by softness of front dental hard consonants; regressive adjacent dissimilation by the method of formation: [чт] > [шт]; transition of [а] to [е] after soft and hissing consonants; use of prothetic [г], [в] at the beginning of the word before vowels; transition of unstressed [о] to [у]; absence of insertive [l] after labial; depalatalization of [р]; use of mn instead of mj). It is proved that the phonetic linguistic elements used are sufficiently representative of the Naddniester dialect. The selected phonetic dialects are a stylistic category; their use is subject to artistic attitudes, i.e., the reproduction of the character’s natural speech, an indication of his belonging to a certain ethnographic group.
Prospects for further study of the stated problem are seen in a thorough study of dialect units in contemporary fiction, in particular the Naddniester dialect, since it is one of the least studied in this aspect.
Značilnosti ravnanja s prebeglimi in zajetimi pripadniki zveznih sil v osamosvojitveni vojni 1991 v Pomurju
Authors: ŠTEINER ALOJZ 
Published: October 2023

Osamosvojitvena vojna leta 1991 v Pomurju je predstavljena v številnih publikacijah. V njih so tudi informacije o ravnanju s prebeglimi in ujetimi pripadniki ter zbirnih centrih o vojnih ujetnikih. Prispevek temelji na proučevanju in analizi tematike, pri tem pa odstira nekatere še nepojasnjene zadeve. Obenem se skozi objektivno predstavitev tematike, kaže značaj slovenske osamosvojitvene vojne.
V prispevku so opisana izhodišča za odpoklic in poziv za pristop pripadnikov JLA v slovenske obrambne sile in terminološke zadrege v odnosu na mednarodno vojno pravo in prakso v Sloveniji leta 1991. Pojasnjena je funkcionalna razmejitve in odgovornosti glede zbirnih centrov med teritorialno obrambo (TO) in organi za notranje zadeve (ONZ). Opisano je nastajanje in delovanje zbirnih centrov za vojne ujetnike (CVU) z nekaterimi posebnostmi v Pomurju. K temu je dodana primerjava števila prebeglih in zajetih v spopadih v Sloveniji in Pomurju 1991 s kazalniki številčnega stanja. Ugotovitvam iz raziskave sledijo zaključki in sklepi. Nekatere od teh so takšni, kot do sedaj še niso bili predstavljeni.
Role of Uterocervical Angle, Cervical Length, and Cervicovaginal Fetal Fibronectin in the Prediction of Preterm Birth
Authors: Etman Mohamed K. , Abd El-Hafeez Ghada M. , Bakry Mohamed S. , El-Baradie Sahar MY. 
Published: October 2023

BACKGROUND:Cervical length measurement and fetal fibronectin (FFN) are widely used to estimate the risk of preterm birth. Another potential predictor of preterm birth is the uterocervical angle, and this additional measurement may improve the risk assessment. This study aimed to predict the onset of labor in women who present with preterm labor through cervical length, uterocervical angle, and FFN.METHODS:A prospective cohort study was carried out on 90 symptomatic women at high risk of preterm labor attending the Gynecology and Obstetrics department at Fayoum University Hospital. FFN in the cervicovaginal fluid was assessed by ELISA technique. The uterocervical angle and cervical length were measured by transvaginal ultrasound. Maternal history and pregnancy data were recorded. Delivery data were subsequently collected.RESULTS:The average age was 21.79 ± 3.3 years, and the average body mass index (BMI) was 24.6 ± 5.8 kg/m2. The mean gestational age (GA) was 32.83 ± 2.3 weeks. Twelve women in our cohort reported previous preterm labor. The cervical length and FFN showed better sensitivity and specificity compared with the uterocervical angle in predicting preterm birth. Logistic regression analysis demonstrated that preterm birth depended only on the cervical length and quantitative FFN.CONCLUSION:The combination of FFN and cervical length could improve preterm birth prediction accuracy.
The Hong Kong genome project: building genome sequencing capacity and capability for advancing genomic science in Hong Kong
Authors: Chu Annie T. W. , Tong Amy H. Y. , Tse Desiree M. S. , Lo Cario W. S. , Lau Carol C. F. , Li Cecilia Y. F. , Tai Nattily S. Y. , Wong Lap W. , Choy Gigi K. C. , Tse Belinda Y. Y. , Lo Su-vui , Sung Ken , Yu Mullin , Hong Kong Genome Project  , Chung Brian H. Y. 
Published: October 2023

Aim: The Hong Kong Genome Project (HKGP) is the first large-scale genome sequencing (GS) project in the Hong Kong Special Administrative Region. The Hong Kong Genome Institute (HKGI) is entrusted with the task of implementing the HKGP. With the aim to sequence 45,000-50,000 genomes in five years, it is the project’s goal to provide participants with more precise diagnosis and personalised treatment, and to drive the application and integration of genomic medicine into routine clinical care.
Methods: The HKGI Laboratory’s hardware and software components were customised to tailor to the needs of the project. Sample handling and storage protocol, DNA extraction, and PCR-free GS workflow were developed and optimised. Quality control indicators and metrics for assessing the quality of samples, sequencing libraries and sequencing data were established.
Results: The Laboratory is designed to facilitate a unidirectional GS workflow to minimise the risk of contamination. The Sample Manager system handles laboratory data generated from the HKGP samples and biobank. The Laboratory handles and analyses approximately 350-500 samples per week, the majority of which are whole blood. During the first 24 months since the launch of the HKGP, 12,937 participants and their family members (6,680 genomes) have been recruited and sequenced. The sequencing capacity of the Laboratory has been further enhanced to include the latest technologies, such as long-read sequencing and multi-omics in order to meet the target of the HKGP.
Conclusion: HKGI Laboratory established a robust GS workflow for the HKGP. The clinical utility of GS will bring precision medicine into routine clinical practice.
Reemergence of arctic-like rabies virus in a rabies-free area in the Amur river basin
Authors: Botvinkin Aleksandr D. , Poleshchuk Elena M. , Chupin Sergey A. , Zarva Ivan D. , Meltsov Ivan V. , Yanovich Vasily A. , Zinyakov Nikolay G. , Sidorov Gennady N. , Andaev Evgeny , Metlin Artem E. 
Published: October 2023

Background: A descriptive epidemiological study of the rabies outbreak in the Amur Region of Russia (ARR), which remained rabies-free from 1972 to 2017, was carried out. During 2018-2022, 49 animal rabies cases and one human rabies death were documented in the ARR. This study aimed to detect possible ways of incursion and features of the spatial spread of rabies virus (RABV) in ARR, which was considered rabies-free for 45 years.Methods: After the beginning of the outbreak, 1,450 animal brain samples were tested using a direct fluorescent antibody test. Genetic analysis of RABV isolates was carried out (n = 9). GIS was used to analyze the spatial spread of rabies in ARR and adjacent territories.Results: Rabies has been confirmed in red foxes (Vulpes vulpes ) - 38.8%, raccoon dogs (Nyctereutes procyonoides ) - 10.2%, wolves (Canis lupus ) - 14.3%, dogs - 18.4% and farm animals - 18.3% (n = 49). The first cases were detected south of the ARR, 30 km from the state border between Russia and China. In 2018-2022, the RABV spread within the forest-steppe landscapes of the Zeya-Bureya Plain northwesterly; the maximum distance from the first recorded event was 192.4 km (Me = 77.6). According to a phylogenetic analysis, the isolates from ARR belonged to the Acrtic-like-2 RABV lineage and showed the maximum similarity to the isolates recovered in the province of Heilongjiang (China, 2011, 2018) and the Jewish Autonomous Region (Russia, 1980).Conclusion: Rabies was most likely introduced by wild carnivores from the adjacent territories of Russia or China, located downstream of the Amur River.
Influence of Porter’s diamond firm strategy, structure and rivalry construct on Pakistan automotive sector
Authors: Butt Muhammad Ahmed , Katuse Paul 
Published: October 2023

The overriding purpose of the study was to ascertain through empirical research whether Porter’s diamond firm strategy, structure and rivalry construct influence the key automotive industry of Pakistan. The Researchers applied positivism research philosophy to help generalize the research study outcomes. Descriptive analytics was deployed to help determine the significance, direction and magnitude of the study. Primary data was obtained from senior managers working in the industry by applying a structured questionnaire for subsequent analysis. While soliciting data, an 85.6% response rate was documented. Statistical techniques were applied which included parametric and nonparametric to arrive at objectively based results to draw safe conclusions. The research findings have created significant value for practitioners in the auto industry as well as the decision-makers at the helm of policy formulation. Pragmatic inferences to be drawn from the research findings include improving the performance of the automotive sector by internalizing Porter’s diamond construct firm strategy, structure, and rivalry. Results in other industries may be tested with future research to help establish generalizability in the area.