bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term outcomes of complete bilateral internal thoracic artery grafting and traditional coronary bypass surgery in patients with multivessel coronary artery disease
Authors: Muradov A. G. , Grinshtein Yu. I. , Drobot D. B. , Sakovich V. A. 
Published: December 2023

Aim. To evaluate the long-term results of complete bilateral internal thoracic artery (BITA) grafting and traditional coronary bypass grafting (CABG) in patients with multivessel CAD.Material and methods. From June 2018 to December 2021, 646 CABG operations were performed in patients with multivessel CAD at the Federal Center for Cardiovascular Surgery (Krasnoyarsk). There were 178 patients receiving BITA grafting and 468 — traditional revascularization technique. After propensity score matching, 356 patients were selected, of which 99 had on-pump BITA (group 1), 178 — on-pump traditional revascularization (group 2), and 79 — off-pump BITA (group 3). There were more males (p=0,143 and p=0,547). The groups were comparable in age (p=0,343 and p=0,104), body mass index (p=0,532 and p=0,759), diabetes (p= 0,705 and p=0,667), the number of hemodynamically significant coronary stenoses (p=0,370 and p=0,595).Results. The follow-up period lasted 32,8±8,52 months. Long-term patient survival was 83,9% in group 2,93% in group 1 (p=0,041) and 94% in group 3 (p=0,039). Freedom from cardiovascular mortality was 100% in both groups of BITA grafting and 92,5% in group 2 (p=0,001 and p=0,039), freedom from major cardiovascular events was 94,2% in group 1, 85,1% in group 2 and 98,5% in group 3 (p=0,032 and p=0,03).Conclusion. BITA grafting is a modern effective and safe method of surgical myocardial revascularization both on- and off-pump. Up to 33 months. BITA grafting was associated with significantly better patient survival, complete freedom from cardiovascular mortality and a lower incidence of major cardiovascular events.
Sex-specific differences in hypertension
Authors: Brodovskaya T. O. , Kasyanov D. V. 
Published: December 2023

The diagnosis of hypertension (HTN) has been known to doctors for many years. Current clinical guidelines represent a unified approach to the treatment and prevention of hypertension in patients of both sexes. Meanwhile, there are data that the development, course, progression and treatment of the disease may differ depending on sex.The aim of the review was to systematize modern ideas about sex differences in hypertension, as well as to substantiate the differentiated treatment among men and women. A literature search for 2013-2023 was conducted in the PubMed, Cochrane Library, Embase, Google Scholar, eLibrary databases using the search phrase "sex differences in hypertension".This work reflects current data regarding sex-specific differences in hypertension, including its development, blood pressure regulation, sex characteristics of risk factors, target organ damage, and features of antihypertensive treatment. Differentiated approach considering sex differences may provide novel strategies for preventing the progression of cardiovascular disease.
Left ventricular longitudinal strain in patients with undifferentiated connective tissue disease and arrhythmia
Authors: Loginova E. N. , Nechaeva G. I. , Dakuko A. N. , Bogatyrev I. V. , Potapov V. V. , Sharun I. V. 
Published: December 2023

Aim. To evaluate the left ventricular longitudinal strain in patients with arrhythmia and undifferentiated connective tissue disease (UCTD).Material and methods. This cross-sectional comparative study included young patients with arrhythmia and UCTD (43 men and 84 women; mean age, 30,82±8,17 years (group 1, n=127)). The control group included volunteers with single phenotypic characteristics of UCTD, comparable in age and sex (9 men and 21 women, mean age, 34,13±6,87 years (group 2, n=30)). A standard clinical examination, 72-hour electrocardiographic monitoring, and speckle-tracking echocardiography were performed.Results. Patients of group 1 were characterized by lower global systolic longitudinal myocardial strain compared to the control group: -22,96% [-24,56%; -21,50%] in group 1 vs -24,73% [-25,25%; -23,84%] in group 2 (p=0,016). A local decrease in longitudinal myocardial strain (in two or more segments) was noted in 62,2% of patients in group 1 and 13,3% of patients in group 2 (p=0,025). In group 1, a relationship was revealed between class I premature ventricular contractions (PVCs) and a longitudinal strain decrease in the medial anterior (r1=0,253, p=0,004) and apical anterior (r1=0,253, p=0,004) segments, as well as between class V PVCs and strain decrease in the basal lower (r1=0,215, p=0,021) and middle anterior (r1=0,211, p=0,023) segments. In addition, there was a moderate correlation between mitral valve prolapse (MVP) and a decrease in longitudinal systolic strain in the basal inferolateral (r1=0,405, p=0,041) and basal anterior (r1=0,519, p=0,003) segments.Conclusion. Local decrease in left ventricular longitudinal systolic strain in association with arrhythmia and MVP in patients with UCTD makes it possible to recommend speckle-tracking echocardiography for early non-invasive assessment of myocardial remodeling in this cohort of patients.
PAZARLAMA ÇEVİKLİĞİ ÖLÇEĞİNİN TÜRKÇEYE UYARLANMASI (GEÇERLİLİK VE GÜVENİLİRLİK ÇALIŞMASI)
Authors: ARSLAN DİNÇ Elif , KAZAN Halim 
Published: December 2023

ÖZET
Bu çalışmada Zhou J., Mavondo F. ve Saunders S.G. (2019)’in geliştirmiş oldukları Pazarlama Çevikliği ölçeği, Türkçeye uyarlanması yapılmıştır. 15 sorudan meydana gelen ölçek soruları işletmelerde pazarlama departmanında yönetici konumunda olan katılımcılara uygulanarak 251 adet anket verisi toplanmıştır. Ölçeğin dil geçerliliği için İngilizce alanında uzman iki akademisyenin çevirileri yapması ile, ölçek maddelerinin gramer ve cümle yapıları incelenmiş, ters çeviri yöntemiyle çeviri kontrol edilmiştir. Alana hâkim dört akademisyen ile ölçek maddeleri ölçülmek istenen kavramla ilişkisi ve Türk kültürüne uygunluk açısından denetlendikten sonra, anket formuna son hali verilmiştir. Ölçeğin yapı geçerliliğini analiz etmek amacıyla güvenilirlik analizi ve geçerlilik analizleri yapılmıştır. Yapılan Açıklayıcı Faktör Analizi (AFA) ile dört faktörlü pazarlama çevikliği alt boyutları proaktiflik, cevap verebilirlik, esneklik ve hız olarak belirlenmiştir. AFA sonucuna göre KMO değeri 0,834 olarak bulunmuş, dört faktörlü ölçeğin toplam varyansın %55.088’ni açıkladığı görülmüştür. AFA’dan elde edilen madde-faktör yapısının doğrulayıcı faktör analizi (DFA) ile model uyumu tekrar test edilmiştir. Buna göre pazarlama çevikliği ölçeğinin dört faktörlü yapısının doğrulandığı görülmüştür. (X2 = 130,675, df = 83, X2/df = 1,574, RMSEA = 0.04, GFI = 0.93, AGFI = 0.90, CFI = 0.93, TLI = 0.92). Buna göre model anlamlı bulunarak, pazarlama çevikliği ölçeğinin madde-yapı ilişkisinin geçerliliği, modelde bir değişikliğe gidilmeden dört alt boyut ve 15 madde ile desteklenmiştir. Ölçeğin güvenilirliği α=0,813 olarak bulunmuştur. Elde edilen bulgular pazarlama çevikliği ölçeğinin Türkçe ölçeğinin kabul edilebilir değerlerde güvenilir ve geçerli bir ölçme aracı olduğu sonucuna ulaşılmıştır.
Induction of bactericidal activity by degradable implants
Authors: Popkov A. V. , Kononovich N. A. , Popkov D. A. , Godovykh N. V. , Tverdokhlebov S. I. , Bolbasov E. N. , Stogov M. V. , Kireeva E. A. , Gorbach E. N. , Litvinov Yu. Yu. 
Published: December 2023

Introduction The problem of implant-associated infections is far from being solved in arthroplasty, osteosynthesis of fractures, and spinal pathology. The development of biodegradable implants with bioactive properties is a promising direction. The purpose of this study was to evaluate the in vitro bactericidal activity of implants made from a degradable material polycaprolactone (PCL) impregnated with hydroxyapatite and an antibiotic.Material and methods To study antibiotic availability, antibiotic-impregnated PCL cylindrical samples (n = 6) were incubated in distilled water at 37 °C. To evaluate the antibacterial properties, samples in the form of porous disks were used: control samples from PCL; 1) PCL samples coated with antibiotic and hydroxyapatite; 2) PCL samples coated only with antibiotic; 3) PCL samples coated only with hydroxyapatite; (n = 6 for each type of tested samples). The disk diffusion method was used to determine the sensitivity of microorganisms to antibiotics. The microbial strains used were S. aureus ATCC 25923, P. aeruginosa ATCC 27853 and E. coli ATCC 25922. Test microorganisms were cultivated on beef peptone agar (MPA) at 37 °C for 24 hours. Quantitative data were subjected to statistical processing.Results It was determined that 82.6 % of the antibiotic was released during the first day of incubation and 8.2 % on the second day. Control samples did not show a bactericidal effect. Samples 3 showed an antibacterial effect against E. coli culture. Samples 1 and 2 equally demonstrated significant inhibition of the growth of S. aureus, P. aeruginosa, and E. coli.Discussion Most of the antibiotic is released into the hydrolyzate during the first two days of incubation. Porous implants made of PCL and impregnated with an antibiotic have pronounced antimicrobial activity against the most common gram-negative and gram-positive bacteria that cause purulent complications in surgical practice. Nanostructured hydroxyapatite on the surface of the implant does not reduce bactericidal activity.Conclusions Porous polycaprolactone implants filled with hydroxyapatite and antibiotics are targeted to stimulate bone regeneration and simultaneously ensure antimicrobial activity. Nanostructured hydroxyapatite on the implant surface does not decrease bactericidal activity.
Bioactive biodegradable polycaprolactone implant for management of osteochondral defects: an experimental study
Authors: Popkov A. V. , Gorbach E. S. , Gorbach E. N. , Kononovich N. A. , Kireeva E. A. , Popkov D. A. 
Published: December 2023

Introducrion Repair of the affected articular surface still remains an unsolved problem.The purpose of this study was to assess the efficacy of a biodegradable polycaprolactone implant coated with hydroxyapatite on the healing of an osteochondral defect of the femoral condyle in rats.Materials and methods An osteochondral defect of the medial femoral condyle was modeled in 76 Wistar rats divided into 2 groups. In the experimental group, the defect was replaced with a biodegradable polycaprolactone membrane coated with hydroxyapatite. In the control group, the defect remained untreated. The results were assessed within a year.Results In the experimental group, the animals had a significantly better range of motion at all stages of the experiment than the control animals. The implant ensured the integrity and congruence of the articular surface. On day 180, a newly formed area of the articular surface of the organotypic structure was observed in the defect. Biomechanical properties of the repaied zone restored after 60 days while in the control one they remained lower by 27-29 %.Discussion Filling the defect with an elastic implant made of polyprolactone with hydroxyapatite provided early functional load on the joint. The structure of the implant, simulating the extracellular matrix, promoted the growth, proliferation and directed differentiation of cells in the area of the osteochondral defect. The moderate rate of biodegradability of the material provided gradual replacement of the implant with organ-specific tissues.Conclusion A biodegradable polycaprolactone implant impregnated with hydroxyapatite particles might be effective for experimental osteochondral defect repair.
Tibial lengthening over a bioactive degradable intramedullary implant: a case report
Authors: Popkov A. V. , Gorbach E. S. , Mamedov U. F. , Stepanov R. V. 
Published: December 2023

Introduction Long duration of distraction osteosynthesis remains an unsolved problem. One of the promising ways to stimulate reparative regeneration of bone tissue is the technology of combined osteosynthesis with intramedullary elastic reinforcement with titanium wires coated with hydroxyapatite. A significant drawback of this combined distraction osteosynthesis is the planned removal of intramedullary wires several months after disassembling the Ilizarov apparatus.The purpose of this work is to demonstrate the possibility of stimulating reparative regeneration and reducing the duration of distraction osteosynthesis using an intramedullary degradable implant with bioactive filling.Methods We present the first in clinical practice case of surgical leg lengthening in a female 10-year-old patient using the Ilizarov apparatus an intramedullary degradable implant made of polycaprolactone (PCL) saturated with hydroxyapatite to stimulate reparative regeneration in the tibia. Monthly radiographic monitoring of the process of reparative regeneration of bone tissue was supplemented by computed tomography after disassembling the Ilizarov apparatus.Results The process of lengthening the tibia was accompanied by pronounced formation of a bone “sleeve” around the implant, which was directly connected to the endosteum of the tibia. The density of bone substance in the medullary canal reached 496.6 HU. The cortical layer of the tibia in the elongation zone increased to 4 mm, and its density was equal to 1288.8 HU.Discussion Leg lengthening of 4 cm was achieved along with simultaneous correction of valgus recurvatum bone deformity at IO = 15 days/cm, that is two times shorter than the generally accepted excellent IO in distraction osteosynthesis according to Ilizarov.Conclusions Biodegradable polycaprolactone implants saturated with hydroxyapatite might be not inferior to titanium wires coated with hydroxyapatite in regard to the degree of osteoinduction and do not require repeated surgical intervention to remove them.
An overview of periodontal disease in pregnancy
Authors: Aloqayfi Mohammed Ibrahim , Alayed Yahya Nasser , Alshareef Manal Abdullah , Alfawzan Amany Sami , Asiry Azhar Hussain , Almalik Nourah Nasser , Almalki Afnan Faisal , Alharbi Ali Abdullah , Alomari Bassem Othman 
Published: December 2023

Periodontal disease (PD), an inflammatory and infectious condition affecting the tissues supporting teeth, is prevalent among pregnant women due to hormonal changes. Studies indicate a link between PD and adverse pregnancy outcomes, including preterm labor and low birthweight newborns, likely due to increased inflammatory mediators. Oral pathogens like Tannerella forsythia and Porphyromonas gingivalis have been associated with these complications. The most prevalent oral conditions affecting pregnant women that may influence the course of their pregnancy are periodontitis, gingivitis, and dental caries. From supragingival plaques to subgingival infections and PD, these conditions are linked to one another. Elevated maternal serum antibodies to these pathogens and inflammatory markers correlate with poor pregnancy outcomes. Animal models further support the connection between PD and fetal health issues. While research suggests that periodontal treatment may reduce the risk, the exact mechanisms remain complex and multifactorial. Integrating dental care into prenatal care is vital for prevention and management.
Cambios en las sociabilidades entre pobres urbanos brasileños (1964-2016)
Authors: Beraldo Ana 
Published: December 2023

Producto de casi una década de investigación en una favela de Belo Horizonte, este artículo busca mostrar la conexión entre las transformaciones del macro contexto político-estatal brasileño y los cambios en las dinámicas de sociabilidad microlocalizadas en los márgenes urbanos de este país entre 1964 y 2016. Combinando una aproximación etnográfica y sociohistórica, el análisis se apoya en i) memorias de los habitantes del barrio sobre el pasado de la favela; ii) consultas de documentos sobre la historia de la ciudad, y iii) observación participante de fenómenos más recientes, cuyo desarrollo acompañé durante mi trabajo de campo. Organizado a partir de los ejes a) dinámica de acceso a derechos políticos y sociales, b) violencia (político-ideológica o criminal-policial), y c) capacidad de consumo, el artículo concluye que, en el periodo estudiado, las clases bajas experimentaron un pasaje desde una sociabilidad centrada en la confianza a una interacción basada en el respeto.
ANTIMYCOTIC ACTIVITY OF THE ISOLATES OF LACTOBACTERIA FROM WA-TER AND MUSSELS OF BLACK SEA
Authors: Merlich A. G. , Kimurzhyi I. I. , Kovalchuk R. R. , Shutylo M. V. , Ivanytsia V. O. 
Published: December 2023

Aim. Determination of the presence of antimycotic activity and its level in thirteen lactobacteria isolates from Black Sea water and mussels. Methods. Antimycotic activity of lactic acid bacteria (LAB) isolates was tested by agar diffusion method in 24-well plates. To determine character of action the plates were incubated for 7 days at 25 °C. Results. For the first time antimycotic activity of marine LAB from Odesa coast was estimated. The majority of the tested isolates of lactobateria exhibited antimycotic activity of high level completely inhibiting (in 100%) as mycelium growth as well as spore formation of Penicillium expansum UKM F-575 and Aspergillus niger UKM F-16706 on second day of the study. Four isolates (M.5.1, M.5.2, M.7.1, M.7.2) showed lower antimycotic activity (from 0 to 75%). Eight LAB isolates from seawater (W.1.1, W.1.2, W.1.3, W.1.4, W.1.5, W.1.дк, W.2.3, W.2.4) and one isolate from mussel liquor (M4.1) completely inhibited mycelial growth and sporulation of P. expansum UКМ F-575 and A. niger UКМ F-16706 even within seven days indicating fungicidal character of action. Conclusions. The most of tested LAB isolates from Black Sea exhibited high antimycotic activity against P. expansum UКМ F-575 and A. niger UКМ F-16706 indicator strains. The most active lactobacteria isolates were W.1.1, W.1.2, W.1.3, W.1.4, W.1.5, W.1.дк, W.2.3, W.2.4 isolated from Black Sea water and M4.1 – from mussel liquor. The character of the revealed antimycotic activity was determined as fungicidal.
THE COMPARISON OF SIDEROPHORES CONTENT IN BACTERIA ISOLATED FROM BLACK SEA MUSSELS
Authors: Martynenko S. A. , Finogenova M. O. , Semenets A. S. , Galkin M. B. 
Published: December 2023

Aim. This research was carried out for determination of ability to produce siderophores by strains of Pseudomonas aeruginosa and Bacillus sp. isolated from Black Sea mussels and for studying characteristics of their synthesis at mono- and co-cultivation of researched strains. Materials and methods. In the study we used four strains of Pseudomonas aeruginosa and two strains of Bacillus sp. Monocultivation and co-cultivation were carried out with these strains on a LB medium. CAS (chrome azurol S) analysis was used to determine the content of synthesized siderophores, the measurement was carried out in spectrophotometer SmartSpec Plus at 630 nm. Conclusions. This study showed that marine strains of P. aeruginosa can produce more siderophores than marine strains of Bacillus sp. At monocultivation, strain P. aeruginosa М1 was able to produce the largest amount of siderophores with value of SU (siderophores units) 65 ± 4% and the smallest one strain B. atrophaeus МН4 with value of SU 21 ± 1%. Co-cultivation provides an increase in production of siderophores in each strain, that is the result of special interactions between different microorganisms. And through it, the combination B. subtilis MC3+P. aeruginosa M1 demonstrated the highest content of siderophores with value of SU 81 ± 6%, the lowest content was shown by combination B. atrophaeus МН4+P. aeruginosa M3 with value of SU 41 ± 4%. And such results showed that co-cultivation is the useful method for obtaining more content of siderophores from already famous strains.
Examining the Continuation of Suicide Prevention in Probation System: Empirical Evidence from Europe
Authors: Baias Carmen-Valeria 
Published: December 2023

The policies of the vast majority of nations and jurisdictions prioritize the prevention of suicide. In an effort to comprehend and eventually prevent suicide, psychologists, social scientists and forensic specialists from a variety of disciplines have provided suicide theories to explain the characteristics that render certain individuals more susceptible to suicidal behavior than most others. This review of the international practices for the continuation of suicide prevention in probation considers risk factors for suicide in probation, how probation can provide initiatives for prevention strategies, and what is currently identified as strategies to lower suicide among persons who are on probation supervision, generating the best practices and evidence. The aim of this review is to explore how to provide suicide prevention program (SPP) to probationers and what are best international practices that ensure the continuation of the suicide prevention program after early conditional release of a prisoner. The author examines implications of findings resulted from these studies and makes suggestions for possible best practices. The programs designed to improve the mental health of at-risk offenders need to be reliable and thoroughly evaluated for effectiveness in probation. Additional services for mentally disturbed offenders need to be arranged after their release from prison in order to be reintegrated into the community. Practical implications are examined.
O jednym odczytaniu Song of Solomon
Authors: Binczycka-Gacek Elżbieta 
Published: December 2023

Przedmiotem analizy w niniejszym artykule będą dwa powiązane z sobą teksty: wydana w 1977 roku powieść Toni Morrison Song of Solomon i poświęcony jej artykuł Ewy Łuczak zatytułowany Powrót do domu w „Pieśni Salomonowej”: nostalgia a budowanie tożsamości. Część moich rozważań chciałabym poświęcić przyjrzeniu się tekstowi Łuczak, dla którego punktem wyjścia są obecne w powieści konteksty polityczne i społeczne. Song of Solomon zostaje w nim zanalizowana w kontekście „dyskursu domu” obecnego w twórczości Morrison, oraz poprzez kategorię nostalgii. W moim artykule chciałabym zwrócić uwagę na inne możliwe interpretacje tekstu noblistki, uzupełniając tym samym interpretację, którą proponuje Ewa Łuczak o nowe konteksty. Kategorię nostalgii proponuję zastąpić odczytaniem Song of Solomon w świetle jednego z najważniejszych mitów diaspory afrykańskiej, wokół którego ustrukturyzowana jest cała powieść – mitu Flying Africans, któremu w tekście Łuczak poświęcone zostało zaledwie jedno zdanie. Mimo iż niniejszy artykuł zawiera pewne elementy polemiczne, chciałabym, aby stanowił przede wszystkim interesujący punkt wyjścia do szerszej dyskusji na temat kulturowej hegemonii zachodnich odczytań tekstów z kręgu literatury postkolonialnej.
Shelf-life Estimation of the Red Ginger Powder in Paper Kraft Packaging using ASLT Method Arrhenius Model
Authors: Saputri Diah Ega , Ahmad Usman , Pujantoro Lilik 
Published: December 2023

Salah satu bentuk olahan jahe merah untuk mempertahankan mutunya yaitu dengan dijadikan bubuk kering. Oleh karena itu diperlukan suatu penelitian untuk mengetahui penurunan mutu bubuk jahe merah dalam kemasan selama penyimpanan serta menduga umur simpannya. Penelitian ini terdiri dari dua tahap, yaitu tahap pertama pembuatan bubuk jahe merah dan tahap kedua penyimpanan bubuk jahe dalam kemasan yang disimpan pada inkubtor dengan metode accelarated shelf-life testing (ASLT). Analisis mutu dilakukan terhadap perubahan kadar air, vitamin C, dan nilai warna. Pengeringan dan pembubukan jahe merah menghasilkan bubuk jahe merah dengan kadar air 10%, kandungan vitamin C 21.03 mg/100g dan nilai warna hasil pengeringan memiliki nilai chroma sebesar 23.47. Berdasarkan mutu kritis bubuk jahe merah yaitu nilai chroma dapat disimpulkan bahwa umur simpan bubuk jahe merah dalam kemasan kertas kraft dan disimpan pada suhu 28 °C (suhu ruang) yaitu selama 292 hari dan jika disimpan pada suhu 30 °C, maka umur simpan bubuk jahe merah dalam kemasan yang sama menjadi 212 hari.