bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence Rate Trends of Breast Cancer Overall and by Molecular Subtype by Race and Ethnicity and Age
Authors: Li Noelani H. Y. , Li Christopher I. 
Published: January 2025

ImportanceBlack and Hispanic women in the US experience higher incidence rates of aggressive molecular subtypes of breast cancer, including triple-negative disease. However, how these rates are changing, particularly across different age groups, has not been well documented.ObjectiveTo assess changes in overall and subtype-specific breast cancer incidence rates in the US by age and race and ethnicity.Design, Setting, and ParticipantsThis cohort study used Surveillance, Epidemiology, and End Results program cancer registry data from 22 US cancer registries on 1 123 658 females who received a diagnosis of invasive breast cancer from 2010 to 2019. Statistical analysis was conducted from August 2023 to October 2024.ExposuresAge and race and ethnicity.Main Outcomes and MeasuresAge-adjusted incidence rates of invasive breast cancer overall and across the 4 major molecular subtypes by age and by race and ethnicity, as well as their associated annual percentage changes using Joinpoint Trend Analysis software.ResultsOf the 1 123 658 participants in the study, 219 112 (19.5%) were younger than 50 years, 409 257 (36.4%) were aged 50 to 64 years, and 495 289 (44.1%) were 65 years or older. A total of 141 703 participants (12.6%) were Hispanic, 3253 (0.3%) were non-Hispanic American Indian or Alaska Native, 78 306 (7.0%) were non-Hispanic Asian or Pacific Islander, 124 560 (11.1%) were non-Hispanic Black, 769 043 (68.4%) were non-Hispanic White, and 6793 participants (0.6%) had an unknown race and/or ethnicity. Overall, breast cancer incidence rates increased 0.5% per year from 2010 to 2019. Variation by race and ethnicity was observed, with increases of 1.4% per year among Hispanic females, 1.9% per year among non-Hispanic American Indian or Alaska Native females, and 2.1% per year among non-Hispanic Asian or Pacific Islander females, while rates increased only 0.8% per year among non-Hispanic Black females and 0.5% per year among non-Hispanic White females. In subtype analyses, increases of the greatest magnitude in recent years were observed in the incidence rates of triple-negative breast cancer per year among participants aged 65 years or older (Hispanic females, 2.3%; non-Hispanic Asian or Pacific Islander females, 5.5%; and non-Hispanic Black females, 4.3%), while remaining unchanged among non-Hispanic White females.Conclusions and RelevanceIn this cohort study of 1 123 658 females with breast cancer over the 10-year period from 2010 to 2019, there were substantial differences in trends in the incidence rates of breast cancer overall and by subtype across different racial and ethnic groups. Further research is needed to understand the factors associated with these trends.
Risk Factors for Developmental Dysplasia of the Hip Before 3 Months of Age
Authors: Tirta Maria , Rahbek Ole , Kold Søren , Husum Hans-Christen 
Published: January 2025

ImportanceTwo meta-analyses published in 2012 found breech presentation, family history of developmental dysplasia of the hip (DDH), female sex, and primiparity to increase the risk of DDH. However, the DDH definition, reference tests, and the age of the examined children varied considerably, complicating the translation of those findings to current screening guidelines.ObjectiveTo evaluate the association of previously proposed risk factors with the risk of sonography-verified DDH.Data SourcesA literature search strategy used MeSH (Medical Subject Heading) terms and text words associated with DDH and prognostic studies or risk factors. PubMed, Embase, and the Cochrane Library were searched on November 23, 2023, to identify the cohort.Study SelectionCriteria included articles that were in English and published from January 1, 1980, to November 23, 2023. Eligible studies included randomized clinical trials and cohort, case-control, and cross-sectional studies that involved participants younger than 3 months in whom a diagnosis of DDH was made by hip ultrasonography using the criterion standard Graf method, reported information on 1 or more of the proposed risk factors, and reported the final diagnosis.Data Extraction and SynthesisCollected variables included an evaluated risk factor, the number of infants with a risk factor, the number of infants without risk factors, and the number of infants with and without DDH in the at-risk group and in the no-risk group. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-Analysis of Observational Studies in Epidemiology (MOOSE) reporting guidelines.Main Outcomes and MeasuresThe main outcome measures were risk of DDH (using odds ratios [ORs]) for each of the risk factors.ResultsOf 5363 studies screened, 20 studies comprising 64 543 infants were included. Breech presentation (OR, 4.15 [95% CI, 2.62-6.57]), family history of DDH (OR, 3.83 [95% CI, 2.05-7.15]), female sex (OR, 2.50 [95% CI, 1.74-3.59]), oligohydramnios (OR, 3.76 [95% CI, 1.66-8.53]), and high birth weight (OR, 2.00 [95% CI, 1.60-2.49]) were associated with a significant increased risk of DDH. Cesarean delivery, primiparity, multiple births, low birth weight, and prematurity were not associated with DDH risk. Heterogeneity was high (I2 &amp;gt; 70.00%) in all of the tested factors except high birth weight (I2 = 0%). The subgroup analysis was performed to investigate these heterogeneities.Conclusions and RelevanceThe findings of this meta-analysis suggest that family history and breech presentation were associated with a significant increase in the risk of sonography-verified DDH in infants younger than 3 months, and a DDH risk increase of female sex was found to be lower than previously reported. A risk increase was detected for oligohydramnios, which has not been included in many screening programs and might also be considered as a referral criterion for hip ultrasonography.
Outpatient Low-Dose Initiation of Buprenorphine for People Using Fentanyl
Authors: Suen Leslie W. , Chiang Amy Y. , Jones Benjamin L. H. , Soran Christine S. , Geier Michelle , Snyder Hannah R. , Neuhaus John , Myers Janet J. , Knight Kelly R. , Bazazi Alexander R. , Coffin Phillip O. 
Published: January 2025

ImportanceThe rise of high-potency opioids such as fentanyl makes buprenorphine initiation challenging due to the risks of precipitated withdrawal, prompting the exploration of strategies, such as low-dose initiation (LDI) of buprenorphine. However, no comparative studies on LDI outcomes exist.ObjectiveTo evaluate outpatient outcomes associated with 2 LDI protocols of buprenorphine among individuals with opioid use disorder (OUD) using fentanyl.Design, Setting, and ParticipantsThis cohort study analyzed data on adults with OUD who self-reported daily fentanyl use and underwent buprenorphine initiation using LDI. Data were extracted from the electronic health records of 2 substance use disorder treatment clinics using a specialty behavioral health pharmacy in San Francisco, California, from May 2021 to November 2022.ExposuresType of LDI protocol selected by individuals: 4-day or 7-day protocol.Main Outcomes and MeasuresThe primary outcome was successful buprenorphine initiation, defined as self-reported LDI completion and pickup of a refill maintenance prescription, and buprenorphine retention. Logistic regression with generalized estimating equations assessed associations between LDI protocol (4-day vs 7-day) and successful initiation, adjusting for multiple attempts, age, gender identity, race and ethnicity, and housing status. Kaplan-Meier survival curves were used to estimate buprenorphine retention, and survival curves were adjusted using a fitted Cox proportional hazards regression model.ResultsA total of 126 individuals (median [IQR] age, 35 [29-44] years; 90 identified as men [71%]; 26 [21%] identified as Black or African American, 20 [16%] as Latine, and 66 [52%] as White individuals) with 175 initiation attempts were included. Across attempts, 72 (41%) had a 4-day LDI protocol and 103 (59%) had a 7-day protocol. Initiation was successful in 60 attempts (34%), including 27 (38%) among 4-day protocol and 29 (28%) among 7-day protocol attempts. Buprenorphine retention rate at 28 days was 21% for a 4-day protocol and 18% for a 7-day protocol. Logistic regression found no significant differences between LDI protocols and successful initiation, while repeated LDI attempts had lower odds of success (second attempt: adjusted odds ratio [AOR], 0.30 [95% CI, 0.14-0.66]; third or more attempt: AOR, 0.22 [95% CI, 0.09-0.53]). Unadjusted and adjusted survival models did not detect a significant difference in retention between LDI protocol types.Conclusions and RelevanceThis cohort study found that among people with OUD using fentanyl and attempting outpatient LDI of buprenorphine, successful buprenorphine initiation and retention rates were low. Future studies should examine interventions to improve LDI success and increase buprenorphine uptake and retention.
Still Lost in the Mall—False Memories Happen and That's What Matters
Authors: Wade Kimberley A. , Riesthuis Paul , Bücken Charlotte , Otgaar Henry , Loftus Elizabeth F. 
Published: January 2025

ABSTRACTFor more than 25 years, psychologists have explored how people can develop rich false memories. Murphy et al. (2023) replicated the original “lost in the mall” study (Loftus and Pickrell 1995), demonstrating that 35% of participants developed false beliefs or memories. Andrews and Brewin (in press) reanalyzed Murphy et al.'s data, concluding that participants who developed false memories reported 25% of the suggested details and 50% of their reports were potentially real memories. Based on this, Andrews and Brewin posited that only 4% of Murphy et al.'s participants developed false memories. We take issue with Andrews and Brewin's conclusions. Given human memory is reconstructive, we should expect participants' reports to contain remnants of accurate memories, self or schematic knowledge, or speculation. Moreover, even low false memory rates can be practically important. What matters is that suggestive influences can lead to substantial memory distortions and even plant new events that had not occurred.
One‐Pot Synthesis of Fully Conjugated Covalent Organic Frameworks via the Pictet–Spengler Reaction for Boosting H2O2 Photogeneration in Real Seawater
Authors: Yue Jie‐Yu , Pan Zi‐Xian , Zhang Rui‐Zhi , Xu Qing , Yang Peng , Tang Bo 
Published: January 2025

AbstractPhotosynthesizing H2O2 from real seawater is a promising and green avenue but suffers from salt‐deactivated effects with limitations on stability and photocatalytic activity. Herein, by the Pictet–Spengler reaction, two fully conjugated thieno[3,2‐c]pyridine‐linked covalent organic frameworks (named TBA‐COF and TCA‐COF) are synthesized for seawater H2O2 photoproduction for the first time. Without sacrificial agents in real seawater and O2, TBA‐COF and TCA‐COF exhibit impressive H2O2 generation rates of 8878 and 6023 µmol g−1 h−1 with the solar‐to‐chemical conversion efficiency of 0.62% and 0.42%, respectively, superior to their Schiff base analogs. Further experimental and theoretical investigations reveal that, compared to the imine‐linkage counterparts, in one‐pot cyclized TBA‐COF and TCA‐COF, the Pictet–Spengler reaction improves their charge carrier separation efficiency, alters the photoreduction center from the triazine and benzene parts to the pyridine units, modulates the energy band structures to drive the H2O2 photoproduction by 2e− oxygen reduction reaction and 2e− water oxidation reaction, and thereby enhances the H2O2 photosynthetic activity. Notably, seawater‐produced H2O2 by flow reactors packed with TBA‐COF can be directly utilized for E. coli sterilization. The present study highlights the one‐pot construction of robust COFs with thieno[3,2‐c]pyridine linkage via the Pictet–Spengler reaction and sustainable producing H2O2 from seawater.
Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced Neurodegeneration
Authors: Rui Tong‐Yu , Huang He‐Zhou , Zheng Kai , Fan Hong‐Wei , Zhang Juan , Guo Zi‐Yuan , Man Heng‐Ye , Brazhe Nadezhda , Semyanov Alexey , Lu You‐Ming , Liu Dan , Zhu Ling‐Qiang 
Published: January 2025

AbstractDietary high salt intake is increasingly recognized as a risk factor for cognitive decline and dementia, including Alzheimer’s disease (AD). Recent studies have identified a population of disease‐associated astrocytes (DAA)‐like astrocytes closely linked to amyloid deposition and tau pathology in an AD mouse model. However, the presence and role of these astrocytes in high‐salt diet (HSD) models remain unexplored. In this study, it is demonstrated that HSD significantly induces enhanced reactivity of DAA‐like astrocytes in the hippocampal CA3 region of mice, with this reactivity being critically dependent on neuronal tau pathology. Neuronal tau pathology activates adenosine A1R signaling, exacerbating tau pathology by inhibiting the Cers1 pathway, which sustains astrocyte reactivity. Additionally, neurons burdened with tau pathology promote astrocyte reactivity via releasing Proteins Associated with Promoting DAA‐like Astrocyte Reactivity (PAPD), with Lcn2 playing a pivotal role. Knockout of Lcn2 or its receptor 24p3R significantly mitigates HSD‐induced DAA reactivity and neuroinflammation. These findings suggest a vicious cycle between tau pathology and A1R signaling, driving DAA‐like astrocyte reactivity. Targeting the Tau‐A1R axis may provide a novel therapeutic strategy for reducing HSD‐induced neuroinflammation and cognitive deficits.
Integrative Transcriptome‐Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibility
Authors: Liang Yan , Xiong Xiang‐Yu , Lin Guo‐Wang , Bai Xiaomeng , Li Fugui , Ko Josephine Mun‐Yee , Zhou Yun‐He , Xu An‐Yi , Liu Shu‐Qiang , He Shuai , Wei Pan‐Pan , Chen Qiu‐Yan , Tang Lin‐Quan , Wang Vivien Ya‐Fan , Mai Hai‐Qiang , Luo Chun‐Ling , Zeng Yanni , Lung Maria Li , Ji Mingfang , Bei Jin‐Xin 
Published: January 2025

AbstractNasopharyngeal carcinoma (NPC) is an Asia‐prevalent malignancy, yet its genetic underpinnings remain incompletely understood. Here, a transcriptome‐wide association study (TWAS) is conducted on NPC, leveraging gene expression prediction models based on epithelial tissues and genome‐wide association study (GWAS) summary statistics from 1577 NPC cases and 6359 controls of southern Chinese descent. The TWAS identifies VAMP8 on chromosome 2p11.2 as a novel susceptibility gene for NPC. Further fine‐mapping analyses pinpoint rs1058588, located within VAMP8, as a causal variant through eQTL colocalization, and GWAS analyses across multiple cohorts, achieving GWAS significance (OR = 1.18, P = 3.09 × 10−10). Functional assays demonstrate that VAMP8 exerts a tumorigenic role in NPC, enhancing cell proliferation, migration, and tumor growth. Mechanically, it is uncovered that rs1058588 modulates VAMP8 expression by altering its binding affinity to miR‐185. Furthermore, the results show that VAMP8 interacts with DHX9 to facilitate the nuclear recruitment of p65, activating the NF‐κB pathway. Collectively, the findings shed light on the genetic predisposition to NPC and underscore the critical role of the functional axis involving miR‐185, VAMP8, DHX9, and the NF‐κB pathway in NPC pathogenesis.
Fabrication of Multifunctional Three‐Component Supramolecular Nano‐Biscuits via Two Macrocycles‐Involved Self‐Assembly for Rice, Citrus and Kiwifruit Protections
Authors: He Xinyu , Yang Jinghan , Chen Xue , Chen Jiajia , Zhao Haicong , Liu Juan , Du Fengpei , Wang Peiyi 
Published: January 2025

AbstractBacterial plant diseases, worsened by biofilm‐mediated resistance, are increasingly threatening global food security. Numerous attempts have been made to develop agrochemicals that inhibit biofilms, however, their ineffective foliar deposition and difficulty in removing mature biofilms remain major challenges. Herein, multifunctional three‐component supramolecular nano‐biscuits (NI6R@CB[7]@β‐CD) are successfully engineered via ordered self‐assembly between two macrocycles [cucurbit[7]uril (CB[7]), β‐cyclodextrin (β‐CD)] and (R)‐2‐naphthol‐based bis‐imidazolium bromide salt (NI6R). This macrocycles‐involved bactericidal material combines many advantages. 1) Alleviate the off‐target movement of droplets on hydrophobic blade surfaces. 2) Enhance the biofilm‐disrupting ability. At a low‐dose of 4.44 µg mL−1, the inhibition rate of biofilm formation reached 78.3%. At 35.5 µg mL−1, the potency to remove mature biofilms reached 77.6%. 3) Efficiently hinder bacterial reproduction, swimming, extracellular polysaccharide production, extracellular enzyme secretion, and virulence to plants. These superior characteristics are undoubtedly transmitted to the in vivo control effect. At 200 µg mL−1, this smart material exhibits superior control efficiencies of 49.6%/65.0%/85.4% against three kinds of bacterial diseases (rice leaf blight, citrus canker, and kiwifruit canker), respectively, surpassing the commercial bactericide—thiodiazole‐copper‐20%SC (33.6%/41.5%/43.2%) and NI6R (40.3%/51.2%/71.2%). Furthermore, NI6R@CB[7]@β‐CD is biosafe to non‐target organisms. This study is instructive for constructing multifunctional agrochemicals in sustainable crop protection.
Prediction of Cyclic O6 Molecules Stabilized by Helium under Pressure
Authors: Hou Jingyu , Zhu Qiang , Weng Xiao‐Ji , Shao Xi , Dong Xiao , Wang Hui‐Tian , Zhou Xiang‐Feng , Tian Yongjun 
Published: January 2025

AbstractOxygen usually exists in the form of diatomic molecules at ambient conditions. At high pressure, it undergoes a series of phase transitions from diatomic O2 to O8 cluster and ultimately dissociates into a polymeric O4 spiral chain structure. Intriguingly, the commonly found cyclic hexameric molecules in other group VIA elements (e.g., S6 and Se6) are never reported in the bulk oxygen. Through extensive computational crystal structure search, herein it is reported that such hexameric O6 molecules can exist in a stable compound HeO3 above 1.9 TPa. The first‐principles calculations reveal that, during the reaction by mixing oxygen with helium, the insertion of helium does not only expand the lattice volume, but also relieves the electron lone pair repulsion among diatomic O2, and thus significantly promoting the formation of cyclic O6 molecules. Furthermore, the transition pathway calculations demonstrate that molecular O2 is dissociated first, and then six oxygen atoms form a polymeric digital 2‐shaped intermediate O6. Subsequently, each unstable intermediate O6 decomposes into two intermedia O3 trimers. Finally, O3 trimers transform into cyclic O6 molecules at high pressure. This study expands the known molecular forms of oxygen and suggests a route to the synthesis of intriguing cyclic O6 molecules.
Enhancing Tumor Cell Affinity and Inhibiting Growth With Albumin‐Coated Crosslinked Chitosan Nanoparticle Micelles
Authors: Tan Xiaowei , Liu Ziyi , Ouyang Cuiling , Deng Minxin , Xiao Jingyi , Xiao Shufen , Huang Tuo , Yu Siyu , Chen Hezhang , Chu Hui , Chen Jian 
Published: January 2025

ABSTRACTChitosan (CS)‐based drug delivery systems often face challenges in obtaining clinical approval. Enhancing the binding affinity of CS‐based carriers to target cells, such as tumor cells, is crucial for their translation from bench to bedside. Strategies like crosslinking (NHS‐disulfide‐NHS) and utilizing materials like albumin have proven effective in strengthening interactions between CS‐based nanoparticles and tumor cells, thereby enhancing cellular uptake (cellular avidity). This study presents a novel approach using crosslinked CS nanoparticles loaded with doxorubicin, featuring reduction‐responsive drug release and albumin coating. The albumin‐coated crosslinked chitosan (ACCC) was assembled via reaction between amino of CS/albumin and NHS‐disulfide‐NHS. The resulting ACCC nanoparticle micelles demonstrate enhanced stability of the micelles. The hybrid crosslinked network ensures stability while providing ample space for drug loading and achieves reduction‐responsive drug release through disulfide bond crosslinking. Moreover, the proposed system possesses excellent biocompatibility. Compared to uncoated crosslinked chitosan nanoparticle micelles, ACCC nanoparticle micelles exhibit potent cytotoxicity against tumor cells, particularly in reducing environment. Fluorescence imaging and flow cytometry analyses confirm the enhanced cellular affinity conferred by albumin coating. These findings underscore the potential of ACCC nanoparticles in improving tumor cell adhesion and anti‐tumor efficacy, thus offering promising prospects for translational medicine in CS‐based drug delivery.
Preparation and Characterization of Waterborne Multihydroxy Crosslinked Polyurethane Hybrid Core–Shell Emulsion
Authors: Zhang Taishun , Zhou Manli , Zhang Bao , Peng Xiaohong 
Published: January 2025

ABSTRACTThe use of waterborne polyurethane (WPU) is becoming increasingly prevalent in the effort to address the issue of glare. However, WPU continues to exhibit certain limitations in terms of its performance, including deficiencies in mechanical properties, and low chemical resistance. Consequently, this study employed polyacrylate (PA) modification to create waterborne polyurethane/acrylate (WPUA) hybrid emulsions with a core–shell structure, aiming to enhance their optical properties. Furthermore, different types of alcohol crosslinkers were added to investigate their effects on the optical and mechanical properties of the coatings. Accordingly, this paper presented the design and preparation of a multihydroxyl crosslinking modified antiglare core–shell PU@PA heteropolymer resin utilizing five different hydroxyl‐containing crosslinking agents: polyhydroxy alcohols, trimethylolpropane, pentaerythritol, xylitol, and dipentaerythritol. The impact of selecting crosslinkers with varying hydroxyl numbers as well as optimizing their concentrations on particle size, gloss, and tensile strength of WPUA was thoroughly examined. Results revealed that with xylitol as the crosslinker at a mass fraction of 0.9%, the emulsion's average particle size was 680.6 nm, the gloss of the coating reached 42.8 GU, and the tensile strength was 22.31 MPa. The resulting functional WPUA exhibited excellent optical and mechanical properties, offering new insights for the development of antiglare coatings.
A review of ectochondral bone and the role of membranes in shaping endochondral bones of the skull
Authors: DeLeon Valerie B. , Smith Timothy D. 
Published: January 2025

AbstractBones of the skull are traditionally categorized as derived from either endochondral or intramembranous bone. In our previous work, we have observed the interaction of different tissue types in growth of the skull. We find the dichotomy of intramembranous and endochondral bone to be too restrictive, limiting our interpretation of sources of biological variation. Here, we advocate for the use of the term ectochondral bone to describe bone that originates from an endochondral model but is directed in its subsequent growth by membranes and other fascial attachments. Growth of the alisphenoid and orbitosphenoid are described as two examples of ectochondral bone, influenced in their shape primarily by the surrounding soft tissues. Ectochondral bone may be an ideal mechanism for rapidly evolving new phenotypes. Instead of evolving novelties by altering morphology of the cartilage template, novel features may be formed by ectochondral ossification, a more direct and rapid mode of osteogenesis than that of the cartilage template.