bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study protocol for a nationwide implementation of internet-based vestibular rehabilitation for patients with chronic vestibular symptoms (I-RECOVER)
Authors: Ngo Hà T. N. , Maarsingh Otto R. , van de Berg Raymond , Blanker Marco H. , Bruintjes Tjasse D. , Castien René , Dijkstra Rob , Rutgers Sandra , Slottje Pauline , Twisk Jos W. R. , Yardley Lucy , Bont Jettie , van Vugt Vincent A. 
Published: November 2023

Abstract
Background
Vestibular rehabilitation is a safe and effective exercise-based treatment for patients with chronic vestibular symptoms. However, it is underused in general practice. Internet-based vestibular rehabilitation (Vertigo Training), which has proven to be effective as well, was developed to increase uptake. We now aim to improve the quality of care for patients with vestibular symptoms by carrying out a nationwide implementation of Vertigo Training. We will evaluate the effect of this implementation on primary care.

Methods
Our implementation study consists of three successive phases:
1) We will perform a retrospective observational cohort study and a qualitative interview study to evaluate the current management of patients with vestibular symptoms in primary care, in particular anti-vertigo drug prescriptions, and identify areas for improvement. We will use the results of this phase to tailor our implementation strategy to the needs of general practitioners (GPs) and patients.
2) This phase entails the implementation of Vertigo Training using a multicomponent implementation strategy, containing: guideline adaptations; marketing strategy; pharmacotherapeutic audit and feedback meetings; education; clinical decision support; and local champions.
3) In this phase, we will evaluate the effect of the implementation in three ways.
a. Interrupted time series. We will use routine primary care data from adult patients with vestibular symptoms to compare the number of GP consultations for vestibular symptoms, referrals for vestibular rehabilitation, prescriptions for anti-vertigo drugs, and referrals to physiotherapy and secondary care before and after implementation.
b. Prospective observational cohort study. We will extract data from Vertigo Training to investigate the usage and the characteristics of participants. We will also determine whether these characteristics are associated with successful treatment.
c. Qualitative interview study. We will conduct interviews with GPs to explore their experiences with the implementation.

Discussion
This is one of the first studies to evaluate the effect of a nationwide implementation of an innovative treatment on Dutch primary care. Implementation strategies have been researched before, but it remains unclear which ones are the most effective and under what conditions. We therefore expect to gain relevant insights for future projects that aim to implement innovations in primary care.
New records of Pantophthalmidae (Diptera: Brachycera) from Northeast Brazil
Authors: Soares Matheus Mickael Mota , Fachin Diego Aguilar , Machado Ronald de Andrade , Ale-Rocha Rosaly 
Published: November 2023

Although Pantophthalmidae are widespread in the Neotropical Region, only three of 20 species of the family are known in the Northeast region of Brazil: Pantophthalmus planiventris (Wiedemann, 1821), Pantophthalmus tabaninus Thunberg, 1819, and Pantophthalmus vittatus (Wiedemann, 1828). In this paper, we record, for the first time, Pantophthalmus comptus Enderlein, 1912 from the state of Maranhão, in area of state covered by Amazon Forest biome, and Pantophthalmus pictus (Wiedemann, 1821) from the state of Pernambuco, near the coast, within the Atlantic Forest biome. These two species have been reported elsewhere from Brazil and now their distribution has expanded to the Northeast. Also, we provide images of a female specimen of P. planiventris, known, in the Northeast region of Brazil, from the state of Maranhão only, and of the male terminalia of P. comptus. This paper increases the number of known species of Pantophthalmidae from the Northeast Brazil to five species.
An fMRI Investigation of the Neurocognitive Processing of Measures and Strategic Objectives
Authors: Black Paul W. , Kirwan C. Brock , Meservy Thomas O. , Tayler William B. , Williams Jeffrey 
Published: November 2023

A central feature of most organizations is the use of measures to represent key elements of performance across multiple strategic objectives. Prior research demonstrates a tendency for individuals to treat these measures as though they are the higher order strategic objectives the measures were intended to represent as opposed to imperfect representations of those strategic objectives—a phenomenon labeled “surrogation.” We employ an experiment to further understand this phenomenon. In this study, we capture neural activation when processing measures and when processing strategic objectives. We find that, in regions of the brain with greater (less) activation for concrete versus abstract words, brain activation is greater (less) when processing measure phrases versus when processing strategy phrases. We further find evidence that greater brain activity and longer response times are associated with less surrogation. This affirms the notion that increased cognitive involvement can reduce surrogation. This paper was accepted by Ranjani Krishnan, accounting. Funding: This work was supported by Auburn University, Brigham Young University, Utah Valley University, and an IMA Research Foundation grant from the Institute of Management Accountants. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.01405 .
A Decomposition of Conditional Risk Premia and Implications for Representative Agent Models
Authors: Chabi-Yo Fousseni , Loudis Johnathan A. 
Published: November 2023

We develop a methodology to decompose the conditional market risk premium and risk premia on higher-order moments of excess market returns into risk premia related to contingent claims on down, up, and moderate market returns. The decomposition exploits information about the risk-neutral market return distribution embedded in option prices, but does not depend on assumptions about the functional form of investor preferences or about the market return distribution. The total market risk premium is highly time-varying, as are the contributions from downside, upside, and central risk. Time-series variation in risk premia associated with each region is primarily driven by variation in risk prices associated with the probability of entering each region at short horizons, but it is primarily driven by variation in risk quantities at longer horizons. Analogous decompositions implied by prominent representative agent models generally fail to match the dynamic risk premium behavior implied by the data. Our results provide a set of new empirical facts regarding the drivers of conditional risk premia and identify new challenges for representative agent models. This paper was accepted by Lukas Schmid, finance. Supplemental Material: The internet appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01663 .
High-sensitivity optical fiber probe for simultaneous measurement of chloride ions and temperature
Authors: Li Xia , Li Yu , Wang Chenxiao , Jin Wa , Fu Guangwei , Fu Xinghu , Bi Weihong 
Published: November 2023

A fiber optic probe for the simultaneous measurement of chloride ions and temperature is presented. The Ag/alginate composite film is used as the reflective surface of the Fabry–Perot interferometer (FPI) and is a sensitive film for the adsorption of chloride ions. The experimental results show that the Fabry–Perot (FP) response sensitivity is approximately 1.4689 nm/µM as the chloride ion concentration changes from 1 to 9 µM, but the fiber Bragg grating (FBG) is insensitive to chloride ions. When the temperature is changed from 35°C to 80°C, the response sensitivities of the FP and the FBG are about 0.7 and 0.01115 nm/°C, respectively.
High diffraction efficiency varied-line-space concave gratings for the
Lyman ultraviolet explorer
Authors: Ren Tao , Qiu Keqiang , Li Angran , Huan Shuhu , Lou Zheng , Ji Li , Li ShuagYing , Hong Yilin 
Published: November 2023

In this paper we present the design and fabrication of the reflection varied-line-space
concave grating (VLSCG) for the project of CAFE (the Census of
warm-hot intergalactic medium, Accretion, and Feedback Explorer),
which aims to detect and map the warm-hot circumgalactic medium via
OVI emission at 103.2 nm and 103.8 nm, using two
off-Rowland-circle spectrograph channels. High diffraction efficiency
at LUV is supposed for the VLSCG, and an aperture ratio as small as is desired for a compact design. The
gratings are fabricated by holographic lithography and ion beam
etching techniques. We introduce an additional lens into the normal
holographic exposing system to generate the varied-line-space grating
patterns. Grooves with triangle profiles are obtained to increase the
diffraction efficiency by oblique ion beam bombardment during the
etching process. Finally, several VLSCGs with a central line density
of 3300 lines/mm have been fabricated successfully. The
measured results show that the groove efficiency reaches
51% at 106.4 nm and 31% at 127.4 nm. We imitated the
working optical path of the spectrometer and used the order of the VLSCG to measure the
image near the exit slit. The results showed that the image of the
point source has a vertical extent of 0.68 mm, and the
aberrations have been corrected.
Understanding reticence to occupy free, novel-design homes: A qualitative study in Mtwara, Southeast Tanzania
Authors: Meta Judith , Mshamu Salum , Halifa Salma , Mmbando Arnold , Wood Hannah Sloan , Wood Otis Sloan , Bøjstrup Thomas Chevalier , Day Nicholas P. J. , Knudsen Jakob , Lindsay Steven W. , Deen Jacqueline , von Seidlein Lorenz , Pell Christopher 
Published: November 2023

Introduction
The population of Africa set to reach 2 billion by 2050. There is therefore great demand for housing across the continent. Research on modified novel designs for housing is a priority to ensure that these homes are not sites of infection for diseases transmission such as malaria. One trial to assess the protection afforded by novel design houses is underway in Mtwara Region, southeastern Tanzania. After constructing 110 of such homes across 60 villages, project staff encountered a certain reticence of the target population to occupy the homes and were faced with accusations of having nefarious intentions. This article explores these accusations, their impacts on home occupancy and lessons for future housing studies.

Methods
This qualitative study drew on in-depth interviews and focus group discussions with ten occupants of the intervention homes, six community leaders and a further 24 community members. Interviews were recorded, transcribed verbatim and translated to English for qualitative content analysis.

Results
In communities around the Star Homes, during construction and handover, project staff were widely associated with ‘Freemasons’, a term used to practices, secrecy, and other conspiracy theories in rural Tanzania. These connections were attributed to other community members and explained in terms of knowledge deficit or envy, with others hoping to be allocated the home. The stories were embedded in assumptions of reciprocity and suspicions about study motives, linked to limited experience of research. The relationship between the accusations of freemasonry and reticence to occupy the houses was not straightforward, with project staff or relatives playing a role in decisions. The stakes were high, because the recipients of Star Homes were the poorest families in targeted communities.

Conclusion
The results indicate the need for long-term and proactive community engagement, which focuses on building relationships and providing information through recognizable voices and formats. Given the stakes at play in housing interventions, research teams should be prepared for the social upheaval the provision of free new housing can cause.
Association between long COVID and vaccination: A 12-month follow-up study in a low- to middle-income country
Authors: Fatima Samar , Ismail Madiha , Ejaz Taymmia , Shah Zarnain , Fatima Summaya , Shahzaib Mohammad , Jafri Hassan Masood 
Published: November 2023

Objective
There is a lack of estimates regarding the at-risk population associated with long COVID in Pakistan due to the absence of prospective longitudinal studies. This study aimed to determine the prevalence of long COVID and its association with disease severity and vaccination status of the patient.

Design and data sources
This prospective cohort study was conducted at the Aga Khan University Hospital and recruited patients aged > 18 years who were admitted between February 1 and June 7, 2021. During this time, 901 individuals were admitted, after excluding patients with missing data, a total of 481 confirmed cases were enrolled.

Results
The mean age of the study population was 56.9±14.3 years. Among patients with known vaccination status (n = 474), 19%(n = 90) and 19.2%(n = 91) were fully and partially vaccinated, respectively. Severe/critical disease was present in 64%(n = 312). The mortality rate following discharge was 4.58%(n = 22). Around 18.9%(n = 91) of the population required readmission to the hospital, with respiratory failure (31.8%, n = 29) as the leading cause. Long COVID symptoms were present in 29.9%(n = 144), and these symptoms were more prevalent in the severe/critical (35.5%, n = 111) and unvaccinated (37.9%, n = 105) cohort. The most prominent symptoms were fatigue (26.2%, n = 126) and shortness of breath (24.1%, n = 116), followed by cough (15.2%, n = 73). Vaccinated as compared to unvaccinated patients had lower readmissions (13.8% vs. 21.51%) and post-COVID pulmonary complications (15.4% vs. 24.2%). On multivariable analysis, after adjusting for age, gender, co-morbidity, and disease severity, lack of vaccination was found to be an independent predictor of long COVID with an Odds ratio of 2.42(95% CI 1.52–3.84). Fully and partially vaccinated patients had 62% and 56% reduced risk of developing long COVID respectively.

Conclusions
This study reports that the patients continued to have debilitating symptoms related to long COVID, one year after discharge, and most of its effects were observed in patients with severe/critical disease and unvaccinated patients.
Non–Pure Intestinal Phenotype as an Indicator of Progression in Sporadic Nonampullary Duodenal Adenomas: A Multicenter Retrospective Cohort Study
Authors: Uema Ryotaro , Hayashi Yoshito , Komori Masato , Shibukawa Narihiro , Hayashi Noriko , Horimoto Masayoshi , Yamada Takuya , Yamamoto Masashi , Hiyama Satoshi , Kinoshita Kazuo , Ogiyama Hideharu , Yamaguchi Shinjiro , Egawa Satoshi , Kanesaka Takashi , Kato Minoru , Yoshii Shunsuke , Tsujii Yoshiki , Keiichiro Honma , Shinzaki Shinichiro , Iijima Hideki , Morii Eiichi , Takehara Tetsuo 
Published: November 2023

INTRODUCTION:
We aimed to evaluate the natural course of sporadic nonampullary duodenal adenomas (SNDAs) and determine the risk factors of progression.

METHODS:
We retrospectively analyzed the follow-up outcomes of patients with biopsy-diagnosed SNDA between April 2010 and March 2016 at 13 institutions. All initial biopsy specimens were centrally evaluated. Only those diagnosed with adenomas were included. Mucinous phenotypes were classified into pure intestinal and non–pure intestinal phenotypes. Cumulative incidence rates of carcinoma and tumor enlargement were evaluated. Tumor enlargement was defined as a ≥25% or 5-mm increase in tumor size.

RESULTS:
Overall, 121 lesions were analyzed. Within a median observation period of 32.7 months, 5 lesions were diagnosed as carcinomas; the cumulative 5-year incidence of carcinoma was 9.5%. Male sex (P = 0.046), initial lesion size ≥10 mm (P = 0.044), and non–pure intestinal phenotype (P = 0.019) were significantly associated with progression to carcinoma. Tumor enlargement was observed in 22 lesions, with a cumulative 5-year incidence of 33.9%. Initial lesion size ≥10 mm (P < 0.001), erythematous lesion (P = 0.002), high-grade adenoma (P = 0.002), Ki67 negative (P = 0.007), and non–pure intestinal phenotype (P = 0.001) were risk factors of tumor enlargement. In a multivariate analysis, an initial lesion size ≥10 mm (P = 0.010) and non–pure intestinal phenotype (P = 0.046) were independent and significant risk factors of tumor enlargement.

DISCUSSION:
Lesion size ≥10 mm and non–pure intestinal phenotype on initial biopsy are risk factors of cancer progression and tumor enlargement in cases with SNDA. Thus, management effectiveness may be improved by focusing on lesion size and the mucinous phenotype.
Pengolahan Sampah Plastik HDPE (High Density Polyethylene) dan PET (Polyethylene Terephtalate) Sebagai Bahan Bakar Alternatif dengan Proses Pirolisis
Authors: Lubis Damian Andreas , Arifin Arifin , Fitrianingsih Yulisa 
Published: November 2023

Penggunaan plastik dan barang-barang berbahan dasar plastik semakin meningkat seiring berkembangnya teknologi, industri, dan juga jumlah populasi penduduk. Perlu dipikirkan upaya lainnya agar sampah plastik bisa diolah menjadi bahan lain yang lebih bermanfaat, salah satunya menjadi bahan bakar minyak sintetis. Tujuan dari penelitian ini adalah untuk memanfaatkan sampah plastik HDPE (High Density Polyethylene) dan PET (Polyethylene Terepthalate) menjadi bahan bakar minyak dengan cara pirolisis untuk mengetahui perbandingan hasil minyak yang diperoleh dari pengolahan sampah plastik jenis HDPE dan PET dengan membandingkan secara kualitatif dan kuantitatif bahan bakar minyak yang dihasilkan dari sampah plastik. Pengolahan sampah plastik mejadi minyak dengan pirolisis ini dilakukan selama 120 menit dengan jumlah sampah plastik yang diperlukan dalam 1 kali percobaan sebanyak 500 gram dengan 3 kali pengulangan. Penelitian ini dilakukan di Laboratorium (Out Door) Air Limbah, Limbah Padat, dan B3 Fakultas Teknik Universitas Tanjungpura dengan parameter yang diuji diantaranya volume, massa jenis, dan viskositas. Hasil pirolisis di uji konsistensinya dengan menggunakan uji statistika non parametrik (Uji Mann Whitney). Berdasarkan hasil penelitian, nilai parameter fisik berdasarkan perubahan volume, massa jenis, dan viskositas minyak hasil pirolisis dari sampah plastik High Density Polyethylene (HDPE) dengan rata-rata sebesar 74 mL, 769 kg/m3, dan 0,77 sentipoise (cP), sedangkan pada minyak hasil pirolisis dari sampah plastik Polyethylene Terephtalate (PET) dengan rata-rata sebesar 27 ml, 794 kg/m3, dan 1,2 sentipoise (cP). Berdasarkan hasil analisis kuantitas dan kualitas serta uji konsistensi dengan statistika dari masing-masing jenis sampah bahwa sampah jenis HDPE lebih layak untuk dijadikan bahan bakar minyak alternatif dibandingkan sampah plastik jenis PET karena nilai minyak hasil dari sampah plastik HDPE mendekati kualitas bahan bakar minyak bensin, sedangkan PET nilainya mendekati minyak tanah.
Analisis Kinerja Pengelolaan IPAL Komunal Sanimas di Kawasan Kota Padang
Authors: Komala Puti Sri , Hidayah Fildza Zatil 
Published: November 2023

Penelitian ini bertujuan untuk menganalisis kinerja pengelolaan, operasional dan pemeliharaan Instalasi Pengolahan Air Limbah (IPAL) Komunal Sanimas di kawasan kota Padang. Evaluasi mengacu pada standar operasional pekerjaan (SOP) Direktorat Jenderal Cipta Karya tentang Operasi dan Pemeliharaan IPAL Komunal oleh Masyarakat Tahun 2016, kriteria disain dan peraturan yang terkait. Kelompok Swadaya Masyarakat (KSM) sebagai pengelola belum memiliki data teknis yang lengkap tentang IPAL dan jaringan perpipaan. Operasional dan pemeliharaan oleh Kelompok Pemanfaat dan Pemelihara (KPP) belum dilakukan secara optimal dan tidak sesuai SOP, karena biaya rutin yang tidak mencukupi akibat tunggakan iuran bulanan. IPAL komunal umumnya terdiri dari bak pengendap, anaerobic baffle reactor (ABR) dan anerobic biofilter (AF) dengan variasi media filter. Dari ketiga IPAL diperoleh unit waktu detensi (HRT) bak pengendap yaitu 5-11 jam, baffle reactor 0,6-0,9 hari, dan biofilter 1-1,4 jam namun total HRT pada IPAL Komunal telah memenuhi kriteria. Parameter BOD, Ammonium dan TSS efluen tidak memenuhi baku mutu.
Evaluasi Status Keberlanjutan Budidaya Rumput Laut Di Kecamatan Pasikolaga Kabupaten Muna (Pendekatan Rapfish- Multi Dimensional Scaling)
Authors: Yusuf La Ode Muhammad Iksan , Ismail Ahyar , Nuva Nuva 
Published: November 2023

Produksi rumput laut tertinggi Kabupaten Muna berlokasi di Kecamatan Pasikolaga, mayoritas masyarakat bekerja sebagai pembudidaya rumput laut, maka dalam menjaga mata pencaharian masyarakat setempat, diperlukan pemahaman tentang aspek keberlanjutan. Penelitian ini bertujuan untuk menganalisis status keberlanjutan budidaya rumput laut melalui pendekatan lima dimensi: ekonomi, ekologi, sosial budaya, teknologi dan kelembagaan. Data yang digunakan dalam penelitian ini mengunakan data primer dan sekunder, data primer diperoleh dari ketua kelompok budidaya dengan cara sensus, sedangkan data sekunder diperoleh dari BPS dan jurnal. Teknik analisis yang digunakan Rapfish Multi Dimensional Scaling. Dari hasil analisis dari indeks keberlanjutan dengan skor 37,51 artinya kegiatan budidaya rumput memiliki status kurang berkelanjutan. Antribut sensitif tertinggi hasil analisis Leverage Root Mean Square dimensi ekonomi (6,53) pemasaran hasil panen, Root Mean Square ekologi (15,55) kesuburan lokasi budidaya, Root Mean Square Sosial budaya (8,80) konflik perebutan lahan budidaya, Root Mean Square teknologi (9,82) keinginan mengunakan teknologi pengeringan rumput laut dan pengolahan, dan kelembagaan (9,21) peran kelompok budidaya. Dari hasil Leverage Root Mean Square tersebut, maka perlu kehadiran pemerintah daerah, swasta dan partisipasi masyarakat dalam mendukung keberlanjutan.
Optimization of a rapid method for screening drugs in blood by liquid chromatography tandem mass spectrometry
Authors: Rodrigo Valero Alba M. , Jorge Oscar Quintela , Serrano Begoña Bravo , Tejedor Sara Ayuso 
Published: November 2023

Abstract

Objectives
In the recent years, liquid chromatography with tandem mass spectrometry has gained popularity in laboratories. This technique has a higher specificity, detects different analytes from a single specimen, measures analytes in distinct matrices, and substantially reduce analytical interference, with respect to immunoassay. The processing and preparation of biological samples are crucial in chromatography. Interferences in blood testing are usually caused by the presence of phospholipids and proteins. The main objective of this study was to improve analytical processes for drug screening by LC-MS/MS using a novel blood sample preparation method based on protein precipitation and removal of phospholipids.

Methods
An evaluation was performed of a new method for the preparation of blood samples based on protein precipitation and removal of phospholipids by LC-Q-q-LIT.

Results
Limit of detection, limit of quantification and measurement range were determined for 56 molecules. The results of 11 cases were compared with those obtained using standard blood collection methods and instruments.

Conclusions
The novel blood preparation and testing method based on LC-Q-q-LIT, a more sensitive technique, has demonstrated to yield comparable results to traditional methods. In addition, this new technique reduces turnaround time and costs.