bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of computed tomography-based lipiodol retention pattern in the assessment of hepatocellular carcinoma complete response following conventional transarterial chemoembolization
Authors: Sweed Enas M. , Moustafa Maha S. , Shafei Ashraf S. , Kamal Tamer A. , Abdlelatif Wessam M. 
Published: January 2024

Abstract
Background
Conventional transarterial chemoembolization (cTACE) has emerged as a major treatment modality for unresectable hepatocellular carcinoma (HCC). Efforts have recently been made to identify biomarkers of HCCs that can potentially predict the response of lesions to transarterial chemoembolization (TACE) therapy. The goal of these efforts is to simplify the decision-making process on whether a patient should choose cTACE or pursue other treatment options. Among these, computed tomography (CT) based lipiodol retention analysis has shown promise in providing valuable insights into post-TACE outcomes. This study aimed to investigate the value of CT-based lipiodol retention pattern in predicting recurrence after a state of complete response (CR) according to modified Response Evaluation Criteria in Solid Tumors (mRECIST) guideline post-cTACE.

Methods
From January 2022 to June 2023, a cohort of 30 patients with 40 HCCs who received a primary cTACE session were identified. The study included patients who underwent 1st cTACE session with no more than three HCCs. Ten HCC lesions were eliminated owing to different reasons (illustrated in the flow chart). Tumor response was evaluated based on mRECIST on 1st follow-up CT with a particular focus on tumors demonstrating a complete response. Patterns of lipiodol retention within these tumors were categorized as complete lipiodol retention pattern (C-Lip), covering the whole tumor, or incomplete lipiodol retention pattern (I-Lip). Recurrence was defined when reappearance of enhancement on arterial-phase images of the treated lesion with subsequent washout on portal/delayed phase images occurred corresponding to findings of restricted diffusion on follow-ups DCE-MRI.

Results
A total of 30 HCCs with a CR were classified into 21 (70%) with C-Lip and 9 (30%) with I-Lip. After a median follow-up of 6.00 ± 2.27 months (3–9 months), 8/9 (88.9%) I-Lip and 5/21 (23.8%) C-Lip showed recurrence on follow-up (DCE-MRI), (p < 0.01), with no significant difference in the time of progression (mean 5.57 ± 2.69 for C-Lip vs. 6.00 ± 2.27 months for I-Lip, with (p < 0.5).

Conclusions
HCCs exhibit complete lipiodol retention alongside mRECIST CR possess a reduced susceptibility of recurrence, thereby potentially benefiting from MRI during subsequent evaluations. Conversely, the presence of incomplete lipiodol retention in conjunction with mRECIST CR is an indication of a high risk of recurrence and may require further treatment.
Expression of PD-L1 clones (22C3 and 28-8) in hepatocellular carcinoma: a tertiary cancer care hospital experience
Authors: Asghar Kashif , Bashir Shaarif , Hassan Muhammad , Farooq Asim , Bakar Muhammad Abu , Bilal Sundus , Hameed Maryam , Mehmood Shafqat , Loya Asif 
Published: January 2024

Abstract
Background
Hepatocellular carcinoma (HCC) is a highly aggressive and rapidly progressing form of cancer with a poor prognosis. Recent advances in the management of HCC focused on the novel immunotherapeutic modalities for patients with advanced disease. PD-L1 has emerged as a promising immunotherapeutic approach for HCC. The evaluation of PD-L1 expression aids in identifying patients who can derive maximum benefits from these therapies. This study aims to examine and compare the expression of PD-L1 using two clones (22C3 and 28-8) in HCC patients.

Methods
Forty-six patients with HCC were selected between 2005 and 2022 from the Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH&RC) in Lahore, Pakistan. The patients' formalin-fixed paraffin-embedded (FFPE) tissue samples were retrieved from the department of pathology to conduct immunohistochemical analysis. Moreover, the clinicopathological data of these patients were gathered from the hospital information system (HIS). To assess the relationship between variables, bivariate analysis was carried out using either the chi-square test or Fisher exact test when necessary.

Results
Among the 46 tissue specimens analyzed, the presence of clone 22C3 was detected in 20 HCC patients, with 10 patients showing high expression (21.7%) and another 10 patients showing low expression (21.7%). 22C3 expression was not observed in 26 patients (56.5%). On the other hand, clone 28-8 was expressed in 10 patients, all of whom exhibited low expression (21.7%), while no expression of clone 28-8 was observed in 36 patients (78.3%). An association was found between the expression of 22C3 and 28-8 PD-L1 clones (p-value 0.01). Furthermore, upon closer examination, it was revealed that 12 cases exhibited positive results for 22C3 but negative results for 28-8. Interestingly, two cases displayed positive results for 28-8 but negative results for 22C3.

Conclusion
We obserevd that the PD-L1 clones, 22C3 and 28-8, are comparable. If PD-L1 expression using 22C3 is negative, considering the use of 28-8 for evaluating expression in HCC patients may be beneficial. However, further validation in a larger cohort is necessary.
Simple and Complex Wheel Running Effect on Depression, Memory, Neuroinflammation, and Neurogenesis in Alzheimer’s Rat Model
Authors: TALEBI VAHID , ALAMDARI KARIM AZALI , PATEL DARPAN I. 
Published: January 2024

ABSTRACT

Introduction
The aim of this study was to investigate 12 wk of simple and complex voluntary wheel running on Alzheimer’s disease (AD), associated biomarkers, and behaviors.

Methods
Sixty male Wistar rats were randomly divided into six groups: healthy control (Con-Sed), AD only (AD-Sed), simple wheel control (SWC), complex wheel control (CWC), simple wheel AD (SWAD), and complex wheel AD (CWAD). Novelty-suppressed feeding test and the Morris water maze test were used to evaluate depression and memory, respectively. Ki67 was measured in the hippocampus, whereas interleukin (IL)-1β and neural/glial antigen 2 (NG2) were measured in both the hippocampus and the prefrontal cortex. One-way ANOVA with Tukey’s post hoc test was performed.

Results
AD-Sed group had significantly lower spacial memory (P < 0.001) compared with Con-Sed. Simple and complex wheel running attenuated these deficits in the SWAD and CWAD groups, respectively (P < 0.001). Only the CWAD group had significantly improved novelty-suppressed feeding test time compared with AD-Sed (P < 0.001), equivalent to the healthy wheel running groups. AD-Sed has significantly higher hippocampal concentrations of Ki67 (P = 0.01) compared with the Con-Sed. Both SWAD and CWAD had significantly reduced Ki67 with similar concentrations compared with the SWC and CWC groups (P > 0.05). AD-Sed animals also presented with significantly higher hippocampal and prefrontal cortex concentrations of IL-1β compared with Con-Sed (P < 0.001). SWAD and CWAD had no effect in changing these concentrations. Complex wheel running significantly increased NG2 in the healthy control and AD models, whereas simple wheel running significantly increased NG2 in the AD model.

Conclusions
The results of our study suggest that complex wheel running might be more advantageous in promoting memory and neuroplasticity while reducing depression that is associated with AD.
Variants of plasma lipoprotein profile in persons with maladaptation
Authors: Barylyak Liliya , Tsymbryla Volodymyr , Zukow Walery , Popovych Igor 
Published: January 2024

Introduction and aim. Atherogenic lipoprotein profile of plasma is an important risk factor for coronary artery disease. It is characterized by high ratio of logarithm of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-Ch) called as “atherogenic index of plasma” (AIP). AIP reflect the actual composition of the lipoprotein spectrum and thus predict both the cardiovascular risk and effectiveness of therapy. This article initiates the project "Relationships between plasma lipoprotein profile and neuroendocrine-immune complex parameters and the influence on them of the factors of the Truskavets’ spa". The first goal is the formation of homogeneous cluster groups.
Material and methods. The object of observation were 41 volunteers: 20 women aged 30-76 years and 21 men aged 24-69 years without clinical diagnose but with dysfunction of neuroendocrine-immune complex and metabolism, characteristic for maladaptation. We estimated lipoprotein profile of plasma: total cholesterol level and its content in composition of HDL, VLDL and LDL. Based on them, two AIPs were calculated: TG/HDL-Ch named as Dobiásová&Frohlich as well as previously widely used Klimov’s AIP as ratio (VLDLCh + LDLCh)/HDLCh.
Results. Using the method of cluster analysis, the sample was divided into 5 homogeneous groups, different from each other. It was found that 11 members of the V cluster, the oldest in the sample, exclusively women, had the maximum for sampling increased total Cholesterol, HDL-Ch and Triglycerides levels. At the opposite pole localized 11 members of I cluster, the youngest in the sample, in whom the levels of listed variables as well as LDLCh and Dobiásová&Frohlich AIP was decreased and gender representation was almost the same. The intermediate positions of the members of the other three clusters reflect, as a rule, the intermediate levels of the listed variables. A characteristic feature of 7 members of IV cluster was the maximally increased levels of both Dobiásová&Frohlich’s and Klimov’s AIP. The age and sex together determines Dobiásová&Frohlich’s AIP on 34%. Overall classification accuracy by 6 discriminant variables is 96,3%.
Conclusion. The plasma lipoprotein profile of persons with maladaptation is characterized by a wide range of values, from increased to decreased. This should be kept in mind during the next study of its connections with the parameters of the neuroendocrine-immune complex.
El sello de calidad FECYT, un reconocimiento y un estímulo para Archivos
Authors: Vega Francisco , Agudelo Suárez Andrés A. , Brocal Francisco , Delclós Jordi , García González Guillermo , García Vega , Ramada José María , Serra Laura , Vargas-Prada Sergio , Utzet Mireia , Serra Consol 
Published: January 2024

Un año más, mediante esta nota editorial, damos cuenta de las estadísticas y los principales avances de nuestra revista.
En cuanto a las estadísticas editoriales, que se detallan en los apartados posteriores, podemos afirmar que son las de una revista consolidada: flujo nutrido y constante de trabajos recibidos/publicados, tasas de aceptación y rechazo proporcionadas, tiempos de gestión razonables y diversidad en las autorías.
El logro más destacable del 2023 fue superar con éxito el proceso de evaluación de la Octava edición de Evaluación de la calidad editorial y científica de las revistas científicas españolas, comúnmente conocido como ‘Sello FECYT’…
Deep learning enabled inverse design of bound states in the continuum with ultrahigh Q factor
Authors: Wang Lanfei , Wang Wenqi , Dong Qiao , Wang Lianhui , Gao Li 
Published: January 2024

Bound states in the continuum (BIC) can be easily engineered to obtain ultrahigh quality (Q) resonances that can greatly enhance sensing and lasing performance, thereby gaining significant attention in the field of nanophotonics. However, the design of high Q BIC resonances that operates at desired wavelengths always demands significant computational time and resources to scan structural parameters. On the other hand, the deep learning enabled approach is well demonstrated for its revolutionary capability in direct nanophotonic inverse design. Developing a fast and accurate design tool for BIC resonating structures can expediate the design process while maximizing the device performance. However, it is generally challenging to train high Q resonances in a deep neural network due to their intrinsic non-linearity and complexity. Here, we adopt a simple and classical tandem deep neural network and prove its efficiency in inverse designing BIC resonances at arbitrary wavelengths ranging from 400 to 1200 nm, with Q factors ranging from a few hundreds to hundreds of thousands. Our approach provides another solid example of applying deep learning tools for designing high performance nanophotonic device for sensing applications.
Enabling targeted mass drug administration for schistosomiasis in north-western Tanzania: Exploring the use of geostatistical modeling to inform planning at sub-district level
Authors: Mathewson Jake D. , van der Spek Linda , Mazigo Humphrey D. , Kabona George , de Vlas Sake J. , Nshala Andreas , Rood Ente J. J. 
Published: January 2024

Introduction
Schistosomiasis is a parasitic disease in Tanzania affecting over 50% of the population. Current control strategies involve mass drug administration (MDA) campaigns at the district level, which have led to problems of over- and under-treatment in different areas. WHO guidelines have called for more targeted MDA to circumvent these problems, however a scarcity of prevalence data inhibits decision makers from prioritizing sub-district areas for MDA. This study demonstrated how geostatistics can be used to inform planning for targeted MDA.

Methods
Geostatistical sub-district (ward-level) prevalence estimates were generated through combining a zero-inflated poisson model and kriging approach (regression kriging). To make predictions, the model used prevalence survey data collected in 2021 of 17,400 school children in six regions of Tanzania, along with several open source ecological and socio-demographic variables with known associations with schistosomiasis.

Results
The model results show that regression kriging can be used to effectively predict the ward level parasite prevalence of the two species of Schistosoma endemic to the study area. Kriging was found to further improve the regression model fit, with an adjusted R-squared value of 0.51 and 0.32 for intestinal and urogenital schistosomiasis, respectively. Targeted treatment based on model predictions would represent a shift in treatment away from 193 wards estimated to be over-treated to 149 wards that would have been omitted from the district level MDA.

Conclusions
Geostatistical models can help to support NTD program efficiency and reduce disease transmission by facilitating WHO recommended targeted MDA treatment through provision of prevalence estimates where data is scarce.
Locomotor activity as an effective measure of the severity of inflammatory arthritis in a mouse model
Authors: Doucet Mélina R. , Laevski Angela M. , Doiron Jérémie A. , Boudreau Luc H. , Surette Marc E. 
Published: January 2024

Objective
Mouse models are valuable in preclinical studies of inflammatory arthritis. However, current methods for measuring disease severity or responses to treatment are not optimal. In this study a smart cage system using multiple sensors to measure locomotor activity was evaluated in the K/BxN serum transfer model of inflammatory arthritis.

Methods
Arthritis was induced in C57BL/6 mice with injections of K/BxN serum. Clinical index and ankle thickness were measured for 14 days. Locomotor activity was measured in smart cages for 23 h periods on Days 0, 7, and 13. The same measurements were taken in mice consuming diets supplemented or not with fish oil to evaluate a preventative treatment.

Results
Initiation, peak and resolution phases of disease could be measured with the smart cages. Locomotor activity including speed, travel distance, number of active movements and rear movements were all significantly lower on Days 7–8 of illness (peak) compared to Days 0 and 13–14 (resolution) (one-way repeated measures analyses, p<0.05). The clinical index and ankle thickness measurements did not capture differences between dietary groups. Significantly increased activity was measured in most of the locomotor parameters in the fish oil group compared to the control mice at both Days 8 and 14 (2-way repeated measures ANOVA, p<0.05).

Conclusion
The measurement of locomotor activity provided a more detailed evaluation of the impact of inflammatory arthritis on animal well-being and mobility than that provided by measuring clinical index and ankle thickness, and could be a valuable tool in preclinical studies of inflammatory arthritis.
Divulgación científica en YouTube en países hispanoamericanos: youtubers vs canales institucionales
Authors: Perdomo Bexi , Cortazar José-Carlos 
Published: January 2024

YouTube se ha configurado como un espacio para la divulgación masiva de la ciencia que ha gozado de una amplia aceptación de la población. Esta investigación tuvo como objetivo analizar la divulgación científica en YouTube en canales institucionales y de Youtubers de ciencia en México, Perú y Bolivia. El abordaje metodológico se hizo sobre las premisas epistemológicas del pragmatismo, por lo que fue un estudio mixto de diseño concurrente. Se empleó un grupo de técnicas sistematizadas empíricas (análisis cuantitativo) y críticas (análisis cualitativo del contenido). Se analizaron 71 vídeos, equivalentes a 40.096,28 minutos de grabación. Estos provenían de cuatro canales de Youtubers de ciencia y de cuatro canales institucionales de México, Perú y Bolivia que se seleccionaron con base en los criterios de inclusión y exclusión. Se observaron diferencias en cuanto al engagement comportamental y alcance en los canales de Youtubers e institucionales. Se identificaron estrategias para la presentación del contenido que favorecen el engagement emocional y cognitivo, pero que son usadas principalmente por los Youtubers de ciencia. Se concluye la necesidad de que las instituciones productoras y gestoras de ciencias incorporen el uso de estas estrategias sencillas y efectivas para una mayor y mejor divulgación de ciencia en YouTube.
Rendimiento del exoma para el diagnóstico temprano de las enfermedades raras genéticas en pacientes pediátricos. Revisión Narrativa
Authors: Piñeros Fernández Martha Cecilia 
Published: January 2024

Introducción: La definición establecida por la Organización Mundial de la Salud de las enfermedades raras es: «aquellas que afectan a menos de 5 a 7 individuos en 10.000 y, aproximadamente del 6 % al 8 % de la población mundial» Temática: la categoría fenotípica más común de los casos pediátricos y de adultos son los trastornos neurológicos en estudios realizados en diferentes países. En enfermedades raras como son los trastornos de las plaquetas e inmunodeficiencias el rendimiento diagnóstico del exoma se aproxima al 25% reportado para enfermedades genéticas de presentación común. Los datos de rendimiento diagnóstico del exoma se encuentran por encima del 50% en enfermedades neurológicas pediátricas tales como enfermedades neuromusculares, trastornos neurometabólicos y paraplejía espástica hereditaria y del 50% en miocardiopatías dilatadas hereditarias. Conclusión: los avances tecnológicos como la secuenciación de nueva generación han facilitado significativamente el diagnóstico y el descubrimiento de genes nuevos en pacientes con enfermedades genéticas raras, especialmente con la introducción de la secuenciación del exoma.
A criação como pedagogia
Authors: Aguilar Gina Maria Monge 
Published: January 2024

Como artista, professora e pesquisadora na área das Artes Cênicas latino-americanas, trabalho frequentemente conectando três campos: criação, [trans]formação e pesquisa. Acredito que os processos de criação como pedagogia são potentes no que diz respeito à formação do/a artista teatral. Esses processos configuram um espaço de [trans]formação no qual se aprende fazendo e onde se entrecruzam os vários campos do fazer do/a artista da cena em contexto acadêmico. Esse fazer pedagógico demanda uma prática artística na qual são importantes os registros, debates e trocas antes e durante a criação, assim como posteriormente, baseados na experiência da criação como pedagogia como um todo. Para exemplificar como tem funcionado essa proposta em um contexto específico, vou trazer o caso dos Projetos Integrados de Criação Cênica (PICCs), que acontecem como disciplinas obrigatórias no Departamento de Artes Cênicas do Instituto de Artes da Universidade Estadual de Campinas, Brasil. Nestes projetos poderemos ver como se entrecruzam a criação, a [trans]formação e a pesquisa cênica em um espaço pedagógico.
Com a palavra os estudantes com deficiência visual: a acessibilidade na educação superior
Authors: Costa José Aparecido da , Neres Celi Correa , Moises Ronaldo Rodrigues 
Published: January 2024

Este artigo objetiva promover reflexões sobre o acesso de estudantes com deficiência visual à educação superior e à ambiência universitária. Para tanto, valeu-se de entrevistas de 6 estudantes com deficiência visual, matriculados em universidades no Estado de Mato Grosso do Sul. Os dados foram analisados na perspectiva da escola justa. Verificou-se o declínio na utilização do Sistema Braille, o que dificulta a acessibilidade em ambiente virtual e que, apesar do amplo conjunto de leis tendentes à garantia do acesso aos estudantes com deficiência à educação superior, torna-se perceptível seu descumprimento, reverberando na dificuldade de acesso, na permanência e, sobretudo o êxito do estudante com deficiência.
Sistemas Municipais de Educação: autonomia e desafios
Authors: Richter Leonice Matilde , Souza Vilma Aparecida de , Souza Raquel Aparecida , Silva Maria Vieira 
Published: January 2024

A presente publicação do volume 13, número 1 de 2024 da Revista Educação e Políticas em Debate (REPOD) coloca em destaque o tema dos Sistemas Municipais de Educação por meio da publicação do Dossiê intitulado “Movimento de Institucionalização e Gestão dos Sistemas Municipais de Educação”, organizado pelas Professoras Rosilene Lagares e Katia Cristina C.F Brito e pelo Professor Roberto Francisco de Carvalho, docentes da Universidade Federal do Tocantins (UFT).
Development of an emotional response model for hospital gown design using structural equation modeling
Authors: Zhao Yu , Zhou Feng , Zhao Yan , Zou Yunding , Wei Xixi 
Published: January 2024

Abstract
Apparel has the potential to influence the external expression of wearer’s emotional state and can even empower them, making patients’ hospital wearing a crucial factor in their emotional experience and medical treatment. This study aims to investigate the emotional factors that drive patients’ behavioral responses to hospital gowns using the pleasure–arousal–dominance (PAD) model. With the survey conduction and data analysis, the results identified that the color and silhouette of hospital gowns lead to the emotional experience of arousal, while the structure leads to the emotional experience of dominance, which in turn brings patients a high sense of pleasure and further affect their acceptance and willingness to continue wearing hospital gowns. Based on the results of the research, new hospital gowns were designed and validated, which further confirmed the relationship between the attributes of hospital gowns and emotions of patients. Thus, by extending the PAD model to the context of patients’ use of hospital gowns, this study provides designers with a basis for creating emotionally driven atmosphere factors in the development of hospital gowns for the Chinese market that improve acceptance and continuation of hospital gowns, making a valuable contribution to knowledge in this field.