bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of overall light-level on the reverse Pulfrich effect
Authors: Rodriguez-Lopez Victor , Chin Benjamin , Burge Johannes 
Published: September 2023

ABSTRACTThe Pulfrich Effect is an illusion characterized by the misperception of the depth and 3D direction of moving objects. Interocular luminance differences cause the Classic Pulfrich effect; the darker image is processed more slowly. Interocular blur differences cause the Reverse Pulfrich effect; the blurrier image is processed more quickly. A common correction for presbyopia—monovision—intentionally induces the optical conditions that cause the Reverse Pulfrich Effect. The effect sizes, and the fact that tens of millions of people wear these corrections every day, raise concerns about public safety. However, although the impact of overall light-level (e.g., nighttime vs. daytime) on the Classic Pulfrich effect has been well-characterized, its impact on the Reverse Pulfrich effect is unknown. Here, using a custom binocular 4f tunable lens optical system that allows the decoupling of retinal illuminance and retinal blur, we report how the Classic and Reverse Pulfrich effects scale with overall light-level. Both effects increase logarithmically with decreases in light-level. These results motivate a characterization of how light level interacts with other optical factors (e.g., higher-order aberrations) that are likely to impact the Reverse Pulfrich effect, and hence the perceptual consequences of monovision corrections.Commercial disclosureV. Rodriguez Lopez: None; B. Chin: None; J. Burge: None.
Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis/release regulators
Authors: Kunitake Koki , Mizuno Tadahaya , Hattori Kazuki , Oneyama Chitose , Kamiya Mako , Ota Sadao , Urano Yasuteru , Kojima Ryosuke 
Published: September 2023

AbstractSmall extracellular vesicles (sEVs) are important intercellular information transmitters in various biological contexts, but their release processes remain poorly understood. Herein, we describe a high-throughput assay platform,CRISPR-assisted individuallybarcoded sEV-based releaseregulator (CIBER) screening, for identifying key players in sEV release. CIBER screening employs sEVs barcoded with CRISPR-gRNA through the interaction of gRNA and dead Cas9 fused with an sEV marker. Barcode quantification enables the estimation of the sEV amount released from each cell in a massively parallel manner. Barcoding sEVs with different sEV markers in a CRISPR pooled-screening format allows genome-wide exploration of sEV release regulators in a subpopulation-specific manner, successfully identifying previously unknown sEV release regulators and uncovering the exosomal/ectosomal nature of CD63+/CD9+sEVs, respectively, as well as the synchronization of CD9+sEV release with the cell cycle. CIBER should be a valuable tool for detailed studies on the biogenesis, release, and heterogeneity of sEVs.
Optimizing the distribution of outcomes across multiple levels of subcontracting in construction projects
Authors: Hosseinian S. Mahdi , Jaberi Amirhomayoun 
Published: September 2023

PurposeAlthough outcome sharing in construction is a well-established concept in the literature, there is still an ongoing debate on the most effective approach for distributing project outcomes between an owner and downstream contracting parties (DCPs). To address this issue, this paper aims to investigate an optimal framework for distributing project outcomes among various levels of subcontracting in construction projects. The framework includes contractors, subcontractors, sub-subcontractors and other related parties.Design/methodology/approachTo formulate the optimization problem, the principal–agent model is utilized. The theoretical development is validated through an experiment conducted with employees from road construction companies.FindingsWhen distributing outcomes among various levels of subcontracting, the sharing should be determined by their contribution to the outcome, effort costs, level of outcome uncertainty and risk preference.Originality/valueThis paper expands on the existing principal–agent theory by incorporating multiple levels of agents, transforming the conventional view of outcome sharing among downstream subcontracting levels into testable hypotheses and well-defined concepts. The paper has practical implications for industry practitioners seeking to effectively allocate benefits and costs throughout a project's subcontracting chain.
Human resource management practices and employee retention in the Indian textile industry
Authors: Kalia Prateek , Singla Meenu , Kaushal Robin 
Published: September 2023

PurposeThis study is the maiden attempt to understand the effect of specific human resource practices (HRPs) on employee retention (ER) with the mediation of job satisfaction (JS) and moderation of work experience (WE) and job hopping (JH) in the context of the textile industry.Design/methodology/approachThis study adopted a quantitative methodology and applied quota sampling to gather data from employees (n = 365) of leading textile companies in India. The conceptual model and hypotheses were tested with the help of Partial Least Squares-Structural Equation Modelling (PLS-SEM).FindingsThe findings of a path analysis revealed that compensation and performance appraisal (CPA) have the highest impact on JS followed by employee work participation (EWP). On the other hand, EWP had the highest impact on ER followed by grievance handling (GRH). The study revealed that JS significantly mediates between HRPs like CPA and ER. During Multi-group analysis (MGA) it was found that the importance of EWP and health and safety (HAS) was more in employee groups with higher WE, but it was the opposite in the case of CPA. In the case of JH behavior, the study observed that EWP leads to JS in loyal employees. Similarly, JS led to ER, and the effect was more pronounced for loyal employees.Originality/valueIn the context of the Indian textile industry, this work is the first attempt to comprehend how HRPs affect ER. Secondly, it confirmed that JS is not a guaranteed mediator between HRPs and ER, it could act as an insignificant, partial or full mediator. Additionally, this study establishes the moderating effects of WE and JH in the model through multigroup analysis.
Allometric scaling of skin weight and thickness to body weight in relation to taxonomic orders and habitats in mammals
Authors: Wada Naomi , Ushiroda Saki , Satoh Ran , Sakurai Masashi , Kawada Shinichiro , Luziga Claudius , Ichikawa Hiroshi 
Published: September 2023

AbstractSkin is the largest organ in a mammal body, and it exhibits most significant range of adaptations to different habitats. It is a complex, biological composite structure, consisting of epidermis, dermis and subcutaneous tissues and is used for the therapeutic application of medical devices to improve healthcare. Extensive studies have been performed on the roles of the skin; however, little is known on its physiological characteristics in relation to body size among different species. The purpose of this study was therefore to evaluate the allometric scaling of skin weight (SW) and thickness (ST) to body weight (BW) in relation to genetics and habitats. Also analysed the relationship of BW to thicknesses of epidermis, dermis and subcutaneous tissues. This study used 249 adult animals of both sexes, belonging to 144 species, clustered in 18 taxonomic orders and five types of habitats. The animals were obtained from various sources in Japan. SW and BW were weighed, and ST was measured using a calliper followed by data analysis. Results showed that SW and ST were related to BW [log SW = 0.969 × logBW − 0636, adjust. R2: 0.975]. The BW increased with increasing skin dermal thickness (y = 0.3916x + 1.5253, adjust. R2: 0.6921), slightly with epidermal thickness (y = 0.2495x + 0.3984, adjust. R2: 0.3402), but not all with the thickness of subcutaneous tissues (y = 0.1454x + 2.2437, adjust. R2: 0.0752). The ratio of SW to BW (SW/BW) distributed over a large range from 0.06 to 0.64 values and varied among animal taxonomic orders and their dwelling habitats. Close relationship of BW to SW/BW was observed in species weighing ≥200 g but not in species weighing <200 g. In conclusion, SW and ST in mammals are determined by BW. The SW/BW varies based on BW, taxonomic orders and habitat and is large in small mammals weighing ≥200 g to provide a mechanism used for survival strategy.
Letter: Incidence of hepatitis B virus reactivation in patients with psoriasis treated with cytokine inhibitors
Authors: Kuo Meng‐Hsuan , Tseng Chih‐Wei , Shao Shih‐Chieh 
Published: September 2023

LINKED CONTENTThis article is linked to El Jamaly et al paper. To view this article, visit https://doi.org/10.1111/apt.17155
Letter: NSBB for fatty liver disease—Still a long way to go
Authors: Xu Hangfei , Zhang Yang , Zhang Jing 
Published: September 2023

LINKED CONTENTThis article is linked to Paternostro et al papers. To view these articles, visit https://doi.org/10.1111/apt.17653 and https://doi.org/10.1111/apt.17702
Therapeutic drug monitoring of methotrexate in patients with Crohn's disease
Authors: van de Meeberg Maartje M. , Fidder Herma H. , Oldenburg Bas , Sundaresan Janani , Struys Eduard A. , Montazeri Nahid S. M. , Mares Wout G. N. , Mahmmod Nofel , van Asseldonk Dirk P. , Lutgens Maurice W. M. D. , Kuyvenhoven Johan P. , Rietdijk Svend T. , Nissen Loes H. C. , Koehestanie Parweez , de Boer Nanne K. H. , de Jonge Robert , Bouma Gerd , Bulatović Ćalasan Maja ,   the Dutch Initiative on Crohn and Colitis (ICC)
Published: September 2023

SummaryBackgroundTherapeutic drug monitoring (TDM) has the potential to improve efficacy and diminish side effects. Measuring methotrexate‐polyglutamate (MTX‐PG) in erythrocytes might enable TDM for methotrexate in patients with Crohn's disease (CD).AimTo investigate the relationship between MTX‐PGs and methotrexate drug survival, efficacy and toxicityMethodsIn a multicentre prospective cohort study, patients with CD starting subcutaneous methotrexate without biologics were included and followed for 12 months. Primary outcome was subcutaneous methotrexate discontinuation or requirement for step‐up therapy. Secondary outcomes included faecal calprotectin (FCP), Harvey Bradshaw Index (HBI), hepatotoxicity and gastrointestinal intolerance. Erythrocyte MTX‐PGs were analysed at weeks 8, 12, 24 and 52 or upon treatment discontinuation.ResultsWe included 80 patients with CD (mean age 55 ± 13y, 35% male) with a median FCP of 268 μg/g (IQR 73–480). After the 12‐month visit, 21 patients (26%) were still on subcutaneous methotrexate monotherapy. Twenty‐one patients stopped because of disease activity, 29 because of toxicity, and four for both reasons. Five patients ended study participation or stopped methotrexate for another reason. A higher MTX‐PG3 concentration was associated with a higher rate of methotrexate drug survival (HR 0.86, 95% CI 0.75–0.99), lower FCP (β −3.7, SE 1.3, p < 0.01) and with biochemical response (FCP ≤250 if baseline >250 μg/g; OR 1.1, 95% CI 1.0–1.3). Higher MTX‐PGs were associated with less gastrointestinal intolerance. There was no robust association between MTX‐PGs and HBI or hepatotoxicity.ConclusionsHigher MTX‐PG3 concentrations are related to better methotrexate drug survival and decreased FCP levels. Therefore, MTX‐PG3 could be used for TDM if a target concentration can be established.
A phenotypic screen with Trypanosoma brucei for discovering small molecules that target the SLiM‐binding pocket of proliferating cell nuclear antigen orthologs
Authors: Actis Marisa , Fujii Naoaki , Mackey Zachary B. 
Published: September 2023

AbstractProliferating cell nuclear antigen (PCNA) is a homo‐trimeric protein complex that clamps around DNA to tether DNA polymerases to the template during replication and serves as a hub for many other interacting proteins. It regulates DNA metabolic processes and other vital cellar functions through the binding of proteins having short linear motifs (SLiMs) like the PIP‐box (PCNA‐interacting protein‐box) or the APIM (AlkB homolog 2 PCNA‐interacting motif) in the hydrophobic pocket where SLiMs bind. However, overproducing TbPCNA or human PCNA (hPCNA) in the pathogenic protist Trypanosoma brucei triggers a dominant‐negative phenotype of arrested proliferation. The mechanism for arresting T. brucei proliferation requires the overproduced PCNA orthologs to have functional intact SLiM‐binding pocket. Sight‐directed mutagenesis studies showed that T. brucei overproducing PCNA variants with disrupted SLiM‐binding pockets grew normally. We hypothesized that chemically disrupting the SLiM‐binding pocket would restore proliferation in T. brucei, overproducing PCNA orthologs. Testing this hypothesis is the proof‐of‐concept for a T. brucei‐based PCNA screening assay. The assay design is to discover bioactive small molecules that restore proliferation in T. brucei strains that overproduce PCNA orthologs, likely by disrupting interactions in the SLiM‐binding pocket. The pilot screen for this assay discovered two hit compounds that linked to predetermined PCNA targets. Compound #1, a known hPCNA inhibitor, had selective bioactivity to hPCNA overproduced in T. brucei, validating the assay. Compound #6 had promiscuous bioactivity for hPCNA and TbPCNA but is the first compound discovered with bioactivity for inhibiting TbPCNA.
Promoting toddlers' self‐regulation and healthy eating habits among families living in poverty: A randomized controlled trial of Recipe 4 Success
Authors: Nix Robert L. , Gill Sukhdeep , Hostetler Michelle L. , Feinberg Mark E. , Francis Lori A. , Stifter Cynthia A. , McNeil Cheryl B. , Kidder Sarah M. , Jones Damon E. , Park Ye Rang , Kim Christina N. , Engbretson Ashleigh G. , Braaten Sarah M. , Tamkin Vivian L. 
Published: September 2023

AbstractThe Recipe 4 Success preventive intervention targeted multiple factors critical to the health and well‐being of toddlers living in poverty. This randomized controlled trial, which was embedded within Early Head Start home visits for 12 weeks, included 242 racially and ethnically diverse families (51% girls; toddler mean age = 2.58 years; data collected 2016–2019). Compared to parents in usual practice home visits, parents in Recipe 4 Success displayed greater sensitive scaffolding of toddlers' learning and more responsive food parenting practices (Cohen's d = .21–.30). Toddlers in Recipe 4 Success exhibited greater self‐regulation and had healthier eating habits (Cohen's d = |.16–.35|). Results highlight the value of Recipe 4 Success in promoting parent and toddler behavior change that could have life‐long benefits.
Evolving approaches in paediatric thyroid cytopathology: A review
Authors: Loberg Matthew A. , Tigue Megan L. , Gallant Jean‐Nicolas , Wang Huiying , Canberk Sule , Weiss Vivian L. 
Published: September 2023

AbstractThe guidelines for the workup of thyroid nodules have been established in adult populations and secondarily applied to paediatric populations. In particular, The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is commonly applied to both adult and paediatric thyroid nodules. However, as paediatric nodules have distinct molecular drivers and behavioural trajectories, there is renewed interest in diagnostic and management strategies that are paediatric specific. Here, we review key differences between paediatric and adult thyroid cancer and recent literature evaluating the use of TBSRTC in paediatric populations.
A comparison between time‐constrained counts and line transects as methods to estimate butterfly diversity and monitor populations in tropical habitats
Authors: Attiwilli Suman , Ravikanthachari Nitin , Kunte Krushnamegh 
Published: September 2023

Abstract
Long‐term species monitoring programmes have revealed catastrophic declines in insect populations and disruption of biological communities that are contributing to biodiversity loss. Such discoveries have been possible because of standardised methods, such as line transects, of counting butterflies and other insects. However, line transects are not feasible in many tropical and mountainous habitats, so alternative methods must be explored.
To tackle this issue, we devised time‐constrained (30‐min) counts and compared butterfly diversity estimated through timed counts and line transects in three tropical habitats in India (evergreen forest, dry deciduous forest and an urban woodland). We tested the relative performance of the two methods in sampling species richness and abundance, as well as numbers of rare, endemic and specialist butterflies.
We observed greater overall species richness, and more species of habitat specialists and endemics per sample in time‐constrained counts in the evergreen forest, but not in the other two habitats. Thus, time‐constrained counts were relatively more efficient in detecting species in the species‐rich evergreen habitat. Apart from this difference, the two sampling methods captured similar levels of species richness and other measures of diversity.
Our study thus shows that time‐constrained counts are a suitable if not a superior alternative to line transects to conduct butterfly diversity surveys and population monitoring in complex tropical landscapes. Due to methodological flexibility and simplicity, time‐constrained counts may be particularly useful to study the impacts of climate change, habitat fragmentation and land use practices on butterfly, Odonata and other insect populations in populous and tech‐ready tropical countries using citizen science frameworks.
Canary in the forest?—Tree mortality and canopy dieback of western redcedar linked to drier and warmer summers
Authors: Andrus R. A. , Peach L. R. , Cinquini A. R. , Mills B. , Yusi J. T. , Buhl C. , Fischer M. , Goodrich B. A. , Hulbert J. M. , Holz A. , Meddens A. J. H. , Moffett K. B. , Ramirez A. , Adams H. D. 
Published: September 2023

AbstractAimForest dieback is increasing from unfavourable climate conditions. Western redcedar (WRC)—a culturally, ecologically and economically important species—has recently experienced anomalously high mortality rates and partial canopy dieback. We investigated how WRC tree growth and dieback responded to climate variability and drought using tree‐ring methods.LocationPacific Northwest, USA.TaxonWestern redcedar (Thuja plicata).MethodsWe collected tree cores from three tree health status groups (no canopy dieback, partial canopy dieback, and dead trees) at 11 sites in coastal (maritime climate) and interior (continental climate) WRC populations. From growth rates, we computed four growth indices that assessed the resilience to drought and estimated the year of death.ResultsWarmer and drier climate conditions in May/June that extended the annual July‐to‐September dry season reduced radial growth in 9 of 11 sites (1975–2020). WRC trees recovered growth to pre‐drought rates within 3 years when post‐drought climate conditions were cooler/wetter than average. However, recovery from drought was slower or absent when warmer/drier conditions occurred during the post‐drought recovery period, possibly leading to the recent and widespread mortality across the coastal population. WRC mortality was portended by 4–5 years of declining growth. Annually‐resolved mortality in coastal populations predominately occurred in 2017–2018 (80% of sampled dead trees), a period that coincided with exceedingly hot temperatures and the longest regionally dry period from May to September (1970–2020). In interior populations, mortality was dispersed among years but associated with warmer and drier conditions from August to September.Main conclusionsOur findings forewarn that a warming climate and more frequent and severe summer droughts, especially in consecutive years, will likely increase the vulnerability of WRC to canopy dieback and mortality and possibly other drought‐sensitive trees in one of the world's largest forest carbon sinks.
Muscle quality is negatively related to hypertension prevalence in adults: Results from NHANES 2011–2014
Authors: Bai Xiaopeng , Zhao Jia , Shi Shuai , Zhu Caiyan , Wang Yufeng 
Published: September 2023

AbstractResistance training could counter hypertension and improve muscle quality (MQ), but current evidence about the correlation between MQ and hypertension is limited. The authors aimed to explore this correlation using the data of participants aged 20–59 from NHANES 2011–2014 via a cross‐sectional study. The MQ was quantified as handgrip strength (kg)/lean soft tissue mass (kg) of the dominant arm. Weighted multivariate logistic regression models were mainly utilized to investigate the MQ—hypertension association; linear trend tests and subgroup analysis were also conducted. Moreover, the authors employed weighted multivariate linear regression models to uncover the association between blood pressure (BP) and MQ. Four thousand four hundred and sixty‐nine individuals were enrolled, and 1167 were hypertensive. Hypertensive participants had a lower MQ than normotensive participants. In the totally adjusted model, each unit elevation in MQ was related to a 7% reduction in hypertension prevalence (p =.002). There was a decreasing trend in hypertension prevalence and in systolic BP as the MQ increased from the bottom to the top quartile across all three models (p for trend ≤.01), with a 28% difference (OR: 0.72, 95% CI: 0.54, 0.95) in hypertension prevalence and a 1.88 mm Hg (95% CI: −3.56, −0.20) difference in SBP between the top and bottom quartiles in the fully adjusted model. Subgroup analysis further confirmed the MQ—hypertension inverse association. In conclusions, the MQ was negatively associated with hypertension prevalence and systolic BP, which suggests the MQ may be a protective factor for hypertension and need to be improved.