bluuebunny/crossref_metadata_2025_split huggingface dataset:
Octreotide improves human lymphatic fluid transport a translational trial
Authors: Holm-Weber Thomas , Skov Frederik , Mohanakumar Sheyanth , Thorup Lene , Riis Troels , Christensen Mikkel Bring , Sonne David Peick , Jensen Per Bo , Bødtkjer Donna Briggs , Hjortdal Vibeke Elisabeth 
Published: November 2023

Abstract

OBJECTIVES
Chylothorax is a complex condition and many different pharmacological agents have been tried as treatment. Octreotide is used off-label to treat chylothorax, but the efficacy of octreotide remains unclear. A decrease in lymph production is suggested as the mechanism. In this cross-over study, we explore the direct effect of octreotide on human lymphatic drainage.

METHODS
Pre-clinical: the effect of octreotide on force generation was assessed during acute and prolonged drug incubation on human lymphatic vessels mounted in a myograph. Clinical: in a double-blinded, randomized, cross-over trial including 16 healthy adults, we administered either octreotide or saline as an intravenous infusion for 2.5 h. Near-infrared fluorescence imaging was used to examine spontaneous lymphatic contractions and lymph pressure in peripheral lymphatic vessels and plethysmography was performed to assess the capillary filtration rate, capillary filtration coefficient and isovolumetric pressures of the lower leg.

RESULTS
Pre-clinical: human thoracic duct (n = 12) contraction rate was concentration-dependently stimulated by octreotide with a maximum effect at 10 and 100 nmol/l in the myograph chamber. Clinical: spontaneous lymphatic contractions and lymph pressure evaluated by near-infrared fluorescence did not differ between octreotide or placebo (P = 0.36). Plethysmography revealed similar capillary filtration coefficients (P = 0.057), but almost a doubling of the isovolumetric pressures (P = 0.005) during octreotide infusion.

CONCLUSIONS
Octreotide stimulated lymphatic contractility in the pre-clinical setup but did not affect the spontaneous lymphatic contractions or lymph pressure in healthy individuals. Plethysmography revealed a doubling in the isovolumetric pressure. These results suggest that octreotide increases lymphatic drainage capacity in situations with high lymphatic afterload.
Nec doctum satis: humanist translation and English recreational song
Authors: Ortiz Joseph M 
Published: November 2023

Abstract
Studies of the literary dimensions of English Renaissance madrigals frequently cordon off these works from non-musical forms, such as the prosodic experiments being carried out by humanist poets or the humanist practices of literary translation and imitation. Conversely, studies of humanist translation in England almost never consider recreational song, instead focusing exclusively on more ‘serious’ genres. However, several collections of recreational song published in the period present these songs as legitimate humanist works. In some cases, these collections offer the first English translations of classical and Renaissance poems. Nicholas Yonge’s Musica transalpina (1588) and Thomas Watson’s Italian madrigalls Englished (1590), for example, call attention to their translations of eminent Italian poets (Petrarch, Ariosto, Tasso) and address themselves to classically learned readers. The humanist character of such anthologies was well enough known to be satirized by Thomas Weelkes in his Ayeres and phantasticke spirites (1608), whose classical references have seldom been seriously considered. At the heart of these exchanges is an implicit debate over whether recreational song texts are an appropriate vehicle for humanist learning.
Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias
Authors: Schuermans Art , Vlasschaert Caitlyn , Nauffal Victor , Cho So Mi Jemma , Uddin Md Mesbah , Nakao Tetsushi , Niroula Abhishek , Klarqvist Marcus D R , Weeks Lachelle D , Lin Amy E , Saadatagah Seyedmohammad , Lannery Kim , Wong Megan , Hornsby Whitney , Lubitz Steven A , Ballantyne Christie , Jaiswal Siddhartha , Libby Peter , Ebert Benjamin L , Bick Alexander G , Ellinor Patrick T , Natarajan Pradeep , Honigberg Michael C 
Published: November 2023

Abstract

Background and Aims
Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutations, is associated with atherosclerotic cardiovascular disease and heart failure. This study aimed to test the association of CHIP with new-onset arrhythmias.

Methods
UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcomes were supraventricular arrhythmias, bradyarrhythmias, and ventricular arrhythmias. Secondary outcomes were cardiac arrest, atrial fibrillation, and any arrhythmia. Associations of any CHIP [variant allele fraction (VAF) ≥ 2%], large CHIP (VAF ≥10%), and gene-specific CHIP subtypes with incident arrhythmias were evaluated using multivariable-adjusted Cox regression. Associations of CHIP with myocardial interstitial fibrosis [T1 measured using cardiac magnetic resonance (CMR)] were also tested.

Results
This study included 410 702 participants [CHIP: n = 13 892 (3.4%); large CHIP: n = 9191 (2.2%)]. Any and large CHIP were associated with multi-variable-adjusted hazard ratios of 1.11 [95% confidence interval (CI) 1.04–1.18; P = .001] and 1.13 (95% CI 1.05–1.22; P = .001) for supraventricular arrhythmias, 1.09 (95% CI 1.01–1.19; P = .031) and 1.13 (95% CI 1.03–1.25; P = .011) for bradyarrhythmias, and 1.16 (95% CI, 1.00–1.34; P = .049) and 1.22 (95% CI 1.03–1.45; P = .021) for ventricular arrhythmias, respectively. Associations were independent of coronary artery disease and heart failure. Associations were also heterogeneous across arrhythmia subtypes and strongest for cardiac arrest. Gene-specific analyses revealed an increased risk of arrhythmias across driver genes other than DNMT3A. Large CHIP was associated with 1.31-fold odds (95% CI 1.07–1.59; P = .009) of being in the top quintile of myocardial fibrosis by CMR.

Conclusions
CHIP may represent a novel risk factor for incident arrhythmias, indicating a potential target for modulation towards arrhythmia prevention and treatment.
It’s a trap?! Escape from an ancient, ancestral sex chromosome system and implication of Foxl2 as the putative primary sex-determining gene in a lizard (Anguimorpha; Shinisauridae)
Authors: Pinto Brendan J , Nielsen Stuart V , Sullivan Kathryn A , Behere Ashmika , Keating Shannon E , van Schingen-Khan Mona , Nguyen Truong Q , Ziegler Thomas , Pramuk Jennifer , Wilson Melissa A , Gamble Tony 
Published: November 2023

Abstract
Although sex determination is ubiquitous in vertebrates, mechanisms of sex determination vary from environmentally to genetically influenced. In vertebrates, genetic sex determination is typically accomplished with sex chromosomes. Groups like mammals maintain conserved sex chromosome systems, while sex chromosomes in most vertebrate clades are not conserved across similar evolutionary timescales. One group inferred to have an evolutionarily stable mode of sex determination is Anguimorpha, a clade of charismatic taxa including monitor lizards, Gila monsters, and crocodile lizards. The common ancestor of extant anguimorphs possessed a ZW system that has been retained across the clade. However, the sex chromosome system in the endangered, monotypic family of crocodile lizards (Shinisauridae) has remained elusive. Here, we analyze genomic data to demonstrate that Shinisaurus has replaced the ancestral anguimorph ZW system on LG7 with a novel ZW system on LG3. The linkage group, LG3, corresponds to chromosome 9 in chicken, and this is the first documented use of this syntenic block as a sex chromosome in amniotes. Additionally, this ~1 Mb region harbors approximately 10 genes, including a duplication of the sex-determining transcription factor, Foxl2, critical for the determination and maintenance of sexual differentiation in vertebrates, and thus a putative primary sex-determining gene for Shinisaurus.
High-sensitivity intelligent packaging films harnessing rose anthocyanins and hydrophilic silica aerogel for visual food freshness monitoring
Authors: Wu Wenjun , Zheng Luman , Yu Jiahao , Liu Liming , Goksen Gulden , Shao Ping 
Published: November 2023

Abstract
The enhancement of the sensitivity for anthocyanin-based indicator films in food freshness monitoring in real time is important for application. In this study, hydrophilic silica aerogel (SiO2NA) was incorporated into corn starch (CS)/chitosan (CH)/rose anthocyanins (RACNs)-encapsulated potato amylopectin nanoparticles (APNPs) composite film to increase the sensitivity for shrimp freshness detection. The microstructure of films revealed that the gas absorption capacity was improved by amorphous SiO2NA via hydrogen interactions. The pore size (1.74–5.60 times), pore volume (3.92–5.60 times), and specific surface area (2.21–2.34 times) of films increased with the addition of SiO2NA. The sensing of NH3 and pH and the reversibility of films were also reinforced. Meanwhile, the pH-responsive films containing SiO2NA changed visibly in color from purple–red to orange–gray and finally to gray, enabling effective monitoring of shrimp freshness during storage at 4 °C. Thus, anthocyanin-based indicator films with improved sensitivity by adding SiO2NA were successfully designed for monitoring shrimp freshness.
Anthocyanin treatment delays the senescence of blueberry fruit by regulating abscisic acid and anthocyanin synthesis processes
Authors: Dai Hongyu , Li Bin , Song Zichong , Tian Jinlong , Wei Baodong , Lang Xushu , Zhou Qian 
Published: November 2023

Abstract

Objectives
The purpose of this work was to examine the general effects of exogenous anthocyanins treatment on the synthesis of abscisic acid (ABA) and anthocyanin in blueberry fruit during postharvest storage under room temperature conditions.

Materials and Methods
Fresh blueberry fruit were treated with 3.0 g/L anthocyanins and stored at room temperature to investigate the effects of the treatment on fruit firmness and nutritional quality. The fruit firmness, ABA content, anthocyanin content and the relative expression levels of key genes were evaluated.

Results
The results demonstrated that anthocyanins treatment decreased the ABA level by inhibiting the expression of the VcNCED1 gene implicated in ABA synthesis. At the same time, the treatment increased the content of endogenous anthocyanin by promoting the expression of anthocyanin biosynthesis genes such as VcC4H, VcF3H, VcF3’5’H, VcANS, and VcAT.

Conclusions
Postharvest anthocyanins treatment promoted the synthesis of endogenous anthocyanin, inhibited the accumulation of endogenous ABA, and delayed the senescence of blueberries by inhibiting fruit softening and the accumulation of active oxygen.
Apolipoprotein E and Its Association With Cognitive Change and Modification of Treatment Effects of Vitamin D3 and Omega-3s on Cognitive Change: Results From the In-Clinic Subset of a Randomized Clinical Trial
Authors: Vyas Chirag M , Kang Jae H , Mischoulon David , Cook Nancy R , Reynolds III Charles F , Chang Grace , Mora Samia , De Vivo Immaculata , Manson JoAnn E , Okereke Olivia I 
Published: November 2023

Abstract

Background
Apolipoprotein E (APOE)-ε4 allele is associated with cognitive decline; however, its potential to modify effects of vitamin D3 and omega-3s supplementation on later-life cognition is unclear. Our objectives were to estimate among the in-clinic subset of a randomized trial: (1) associations between APOE-ε4 and global and domain-specific cognitive change, with exploration of potential sex and race differences; and (2) modification by APOE-ε4 of effects of vitamin D3 and omega-3s supplementation on cognitive change.

Methods
From an ancillary study of depression prevention within a completed 2 × 2 factorial trial testing vitamin D3 (2 000 IU per day), omega-3s (1 g per day), and/or placebos, we included 743 older adults with baseline in-person neuropsychiatric assessments and APOE genotyping data. The primary outcome was change in global cognition (averaging z-scores of 9 tests) over 2 years. Secondarily, episodic memory and executive function/attention z-scores were examined. General linear models of response profiles with multiplicative interaction terms were constructed; stratified results were reported.

Results
Mean age (standard deviation) was 67.1 (5.3) years; 50.6% were females; 24.9% were APOE-ε4 carriers. Compared to noncarriers, APOE-ε4 carriers had worse 2-year change in global cognition and episodic memory; differences were more apparent among females than males. There was no variation by race in APOE-ε4 associations with cognition. APOE-ε4 did not significantly modify effects of vitamin D3 or omega-3s, compared to placebo, on change in global cognition, episodic memory, or executive function/attention.

Conclusions
APOE-ε4 was associated with worse cognition but did not modify overall effects of vitamin D3 or omega-3 supplementation on cognition over 2 years.
Technological externalities and wages: new evidence from Italian NUTS 3 regions
Authors: Dughera Stefano , Quatraro Francesco , Ricci Andrea , Vittori Claudia 
Published: November 2023

Abstract
In this paper, we investigate the relationship between local wages and the internal structure of the regional knowledge base. The purpose is to assess if the workers’ compensations are related to the peculiarities of the knowledge base of the regions in which they supply their labor services. The test of this hypothesis is based on the assessment of the impact of related vis-à-vis unrelated knowledge variety on cross-regional wage differentials. The empirical analysis is carried out by exploiting patent data and a unique employer–employee administrative dataset. First, using OECD-PATREG data on patent filing, we build information entropy indexes proxying the variety of NUTS 3 regions’ knowledge bases, and the decomposition in the related and unrelated component. Second, we assess the impact of these indexes on wages based on administrative data from the Italian National Institute of Social Security. Our results suggest that workers employed in regions with a heterogenous knowledge structure earn positive wage premia, while related variety has a negative effect on compensation levels.
Re-Politicizing the Traumatic Body through Art: Guillermo Núñez, Ariel Dorfman and the Political Transition in Chile
Authors: Çolak Erdem 
Published: November 2023

ABSTRACT
This article aims to explore the potential of art to create alternatives to hegemonic narratives in post-traumatic societies and the role of art in the re-politicization of both the artist and the audience. It discusses the role of art in constructing the ethics and memory of Never Again through the visual artworks of Guillermo Núñez (1930) and Ariel Dorfman’s (1942) play Death and the Maiden (1990). Such artistic productions enable the re-participation of the traumatized body in political life not only through the represented story but also through the active reflection and agency of the art producer and the viewer. In this way, they contribute to making visible the passive remembering that is often underestimated in the battle of memories, and to transforming abstract and generalizing facing practices in transitional periods into individual and specific ‘face-ings.’
A unified and constructive framework for the universality of neural networks
Authors: Bui-Thanh Tan 
Published: November 2023

Abstract
One of the reasons why many neural networks are capable of replicating complicated tasks or functions is their universal approximation property. Though the past few decades have seen tremendous advances in theories of neural networks, a single constructive and elementary framework for neural network universality remains unavailable. This paper is an effort to provide a unified and constructive framework for the universality of a large class of activation functions including most of the existing ones. At the heart of the framework is the concept of neural network approximate identity (nAI). The main result is as follows: any nAI activation function is universal in the space of continuous functions on compacta. It turns out that most of the existing activation functions are nAI, and thus universal. The framework induces several advantages over the contemporary counterparts. First, it is constructive with elementary means from functional analysis, probability theory, and numerical analysis. Second, it is one of the first unified and constructive attempts that is valid for most of the existing activation functions. Third, it provides new proofs for most activation functions. Fourth, for a given activation and error tolerance, the framework provides precisely the architecture of the corresponding one-hidden neural network with a predetermined number of neurons and the values of weights/biases. Fifth, the framework allows us to abstractly present the first universal approximation with a favorable non-asymptotic rate. Sixth, our framework also provides insights into the developments, and hence providing constructive derivations, of some of the existing approaches.
Plant Science Knowledge Graph Corpus: a gold standard entity and relation corpus for the molecular plant sciences
Authors: Lotreck Serena , Segura Abá Kenia , Lehti-Shiu Melissa D , Seeger Abigail , Brown Brianna N I , Ranaweera Thilanka , Schumacher Ally , Ghassemi Mohammad , Shiu Shin-Han 
Published: November 2023

Abstract
Natural language processing (NLP) techniques can enhance our ability to interpret plant science literature. Many state-of-the-art algorithms for NLP tasks require high-quality labelled data in the target domain, in which entities like genes and proteins, as well as the relationships between entities, are labelled according to a set of annotation guidelines. While there exist such datasets for other domains, these resources need development in the plant sciences. Here, we present the Plant ScIenCe KnowLedgE Graph (PICKLE) corpus, a collection of 250 plant science abstracts annotated with entities and relations, along with its annotation guidelines. The annotation guidelines were refined by iterative rounds of overlapping annotations, in which inter-annotator agreement was leveraged to improve the guidelines. To demonstrate PICKLE’s utility, we evaluated the performance of pretrained models from other domains and trained a new, PICKLE-based model for entity and relation extraction (RE). The PICKLE-trained models exhibit the second-highest in-domain entity performance of all models evaluated, as well as a RE performance that is on par with other models. Additionally, we found that computer science-domain models outperformed models trained on a biomedical corpus (GENIA) in entity extraction, which was unexpected given the intuition that biomedical literature is more similar to PICKLE than computer science. Upon further exploration, we established that the inclusion of new types on which the models were not trained substantially impacts performance. The PICKLE corpus is, therefore, an important contribution to training resources for entity and RE in the plant sciences.
Association between patient choice of provider and patient-reported experience
Authors: Kim Do Hee , Kim Bomgyeol , Jang Suk-Yong , Lee Sang Gyu , Kim Tae Hyun 
Published: November 2023

Abstract
Health providers are striving to create a more positive, patient-centred experience. However, existing scholarly research about the association between determinants of patient choice of provider and patient-reported experience remains insufficient to effectively promote patient-centredness in healthcare systems. This study used a sample from the nationally representative 2020 Healthcare Experience Survey. Among the respondents (n = 12 133), 6809 who used outpatient services were selected for analysis. The variable of interest was the determinant of the patient choice of provider, and the dependent variables were patient-reported experiences (e.g. general satisfaction, experience with doctors, and experience with health providers and nurses). Data were analyzed using a multivariable logistic regression model by correcting for covariates. General satisfaction was positively associated with providers’ expertise factors and public image factors [providers’ expertise factors: odds ratio (OR), 2.96; 95% confidence interval (CI), 2.44–3.59; public image factors: OR, 1.26; 95% CI, 1.02–1.55] satisfied more general satisfaction. Similar results were found for experience with doctors (providers’ expertise factors: OR, 4.50; 95% CI, 2.77–7.32; other factors: OR, 0.37; 95% CI, 0.16–0.81) and experience with health providers and nurses (providers’ expertise factors: OR, 2.66; 95% CI, 1.99–3.57; image factors: OR, 1.53; 95% CI, 1.09–2.14). Our study’s findings suggest that to improve patient-reported experience, health providers must better manage providers’ expertise factors and public image factors. Health providers can improve patient-reported experience by increasing communication skills and proper information about the nature is important. Moreover, health providers must manage public image factors comprehensively and continuously by maintaining good quality of care and to brand patients.
Are adverse events related to the completeness of clinical records? Results from a retrospective records review using the Global Trigger Tool
Authors: Scarpis Enrico , Cautero Peter , Tullio Annarita , Mellace Flavio , Farneti Federico , Londero Carla , Cocconi Roberto , Brunelli Laura 
Published: November 2023

Abstract
Clinical record (CR) is a tool for recording details about the patient and the most commonly used source of information for detecting adverse events (AEs). Its completeness is an indicator of the quality of care provided and may provide clues for improving professional practice. The primary aim of this study was to estimate the prevalence of AEs. The secondary aims were to determine the completeness of CRs and to examine the relationship between the two variables. We retrospectively reviewed randomly selected CRs of patients discharged from the Academic Hospital of Udine (Italy) in the departments of general surgery, internal medicine, and obstetrics between July and September 2020. Evaluation was performed using the Global Trigger Tool and a checklist to evaluate the completeness of CRs. The relationship between the occurrence of AEs and the completeness of CRs was analyzed using nonparametric tests. A binomial logistic regression analysis was also performed. We reviewed 291 CRs and identified 368 triggers and 56 AEs. Among them, 16.2% of hospitalizations were affected by at least one AE, with a higher percentage in general surgery. The most common AEs were surgical injuries (42.6%; 24) and care related (26.8%; 15). A significant positive correlation was found between the length of hospital stay and the number of AEs. The average completeness of CRs was 72.9% and was lower in general surgery. The decrease in CR completeness correlated with the increase in the total number of AEs (R = −0.14; P = .017), although this was not confirmed by regression analysis by individual departments. Our results seem to suggest that completeness of CRs may benefit patient safety, so ongoing education and involvement of health professionals are needed to maintain professional adherence to CRs.