bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiología de la bacteremia en el servicio de oncología pediátrica, reporte 2022, Hospital de Solca-Guayaquil.
Authors: Bonilla Núñez Aníbal , Aveiga Reinoso Fabiola , González Cabrera Andrés , Espín Custodio Luis 
Published: December 2023

Introducción: Las infecciones son una de las principales complicaciones en la población oncológica pediátrica debido al uso de tratamientos mielo ablativos. El monitoreo continuo de los microorganismos involucrados y su susceptibilidad a los antibióticos se ha vuelto tan importante como el uso racional de los mismos para evitar las resistencias al tratamiento. El objetivo del presente estudio fue establecer la epidemiología de los agentes patógenos hospitalarios y con esos datos establecer un protocolo de manejo empírico inicial, eficiente y eficaz.
Métodos: Se analizan los hemocultivos tomados a niños febriles neutropénicos, hospitalizados en el departamento de pediatría del Instituto Oncológico Nacional, Solca Guayaquil, durante el año 2022. Los cultivos se tomaron directamente de sangre periférica y los retro cultivos de muestras de dispositivos venosos. La identificación de los microrganismos y su sensibilidad se realizó en el departamento de microbiología de la institución.
Resultados: Se analizan 1019 cultivos, 165 fueron positivos (16.19 %), 147 nuevos microrganismos,18 cultivos de seguimiento. Se identificaron bacterias en 101 casos (68.71 %) y hongos en los 46 restantes (31.29 %). Los principales microorganismos aislados fueron bacterias gramnegativas, siendo la Klebsiella pneumoniae la más frecuente (16.33 %). Entre los grampositivos, la mayoría son estafilococos coagulasa negativos. Estafilococcus aureus 7.48 %. El principal hongo aislado fue Cándida parapsilosis (17.69 %). No se aisló Aspergillus spp.
Conclusiones: Los resultados fueron no comparables con la epidemiología del año previo, existiendo cambios específicos, que obligaron el uso de nuevos antibióticos.
LAS REDES SOCIALES Y SU INFLUENCIA EN LA IMAGEN INSTITUCIONAL DE LA FUERZA AÉREA DEL PERÚ, AÑO 2022
Authors: Huasasquiche Miranda Ricardo Enrique 
Published: December 2023

RESUMEN

El presente trabajo de investigación fue desarrollado con el objetivo principal de determinar la relación entre las redes sociales y la imagen institucional de la Fuerza Aérea del Perú, el año 2022. La investigación es de tipo básica, enfoque cuantitativo, alcance Correlacional, diseño no experimental y corte transversal Correlacional, en el que fueron tomadas en cuenta las variables Redes sociales e Imagen Institucional. Se consideró como población, al personal de Aspirantes de la EOFAP, y Alumnos de 1er Año de la ESOFA, el año 2022, con un total de 323, personas. La muestra fue de tipo probabilística, estratificada de fijación proporcional y un total de 176 personas. Los instrumentos de recolección de datos, fueron dos de creación y adaptación propia, los que asimismo fueron sometidos a las pruebas de validez de contenido y de confiablidad. Estos hicieron posible recolectar información sobre cómo las redes sociales se relacionan con la imagen institucional de la Fuerza Aérea del Perú. Para el análisis de datos y la descripción de la percepción de la muestra, se cargaron y tabularon los datos recogidos al aplicar las encuestas, las cuales se presentan en tablas de contingencia e histogramas. Se concluyó mediante el estudio, que las redes sociales se relacionan de manera significativa y positiva, en la imagen institucional de la Fuerza Aérea del Perú, el año 2022.
PELATIHAN PENGAJUAN JABATAN FUNGSIONAL MELALUI WEBSITE SIKOMING DI INSTITUT PENDIDIKAN NUSANTARA GLOBAL
Authors: Habibi Ridwan , Muttaqin Muh Zaini Hasanul , Rosyidi Ahmad Zuhri 
Published: December 2023

SIKOMING merupakan website resmi LLDIKTI wilayah VIII yang digunakan untuk pengajuan jabatan fungsional dosen di wilayah kerjanya. Dalam pengaplikasiannya banyak sekali permasalahan yang muncul seperti (a) dosen belum meahami tentang Sikoming; (b) kesulitan dalam mengisi formulir; (c) kesulitan dalam mengadakan dokumen sebagai bukti. Tentunya ini menjadi perhatian sehingga perlu diadakan sebuah pelatihan. Dalam pelaksanaan pengabdian kepada masyarakat ini dilaksanakan dengan presentasi, tanya jawab, diskusi dan praktek pengisian formulir pengajuan melalui website SIKOMING. Hasil dari kegiatan pelatihan ini adalah para peserta berhasil menyelesaikan pengajuan formulir pengajuan jabatan fungsional melalui website SIKOMING. Selain itu para peserta juga merasa antusias untuk mengikuti pelatihan.
Discovery of Ultrasmall Polar Merons and Rich Topological Phase Transitions: Defects Make 2D Lead Chalcogenides Flexible Topological Materials
Authors: Xu Tao , Qian Tao , Wang Jie , Hirakata Hiroyuki , Shimada Takahiro , Kitamura Takayuki 
Published: December 2023

AbstractAtomic‐scale polar topological configurations, such as skyrmions and merons, have garnered enormous interest due to their rich emergent physical phenomena and promising applications in next‐generation electronics. Despite recent progress in the exploration of 2D ferroelectrics, isolated polar topological structures in 2D lattices have not yet been explored. Here, an original design principle is proposed to remove the point group limit for polar structures while achieving atomic‐scale polar topological structures in non‐ferroelectric monolayers caused by defects in 2D materials. The first‐principles calculations show that an isolated polar meron with a diameter < 3.0 nm is generated in the deficient lead chalcogenide monolayer, and its formation is attributed to the synergic effects of vacancy‐induced radial atomic displacements and symmetry reduction in 2D materials. The emergent polar meron can transform to rich topological configurations under external stimuli or by manipulation of the defect concentrations. Furthermore, this strategy of atomic‐scale symmetry breaking via point defect engineering can be applied to a wide variety of 2D materials to induce polar topological structures. This work generalizes the polar topology from perovskite oxides to 2D materials, facilitating exciting opportunities to create high‐density topological configurations that enable the exploration of meron/skyrmion‐based functional nanodevices.
Ligand‐Screened Cerium‐Based MOF Microcapsules Promote Nerve Regeneration via Mitochondrial Energy Supply
Authors: Jiang Xinzhao , Wang Wei , Tang Jincheng , Han Meng , Xu Yichang , Zhang Lichen , Wu Jie , Huang Yiyang , Ding Zhouye , Sun Huiwen , Xi Kun , Gu Yong , Chen Liang 
Published: December 2023

AbstractAlthough mitochondria are crucial for recovery after spinal cord injury (SCI), therapeutic strategies to modulate mitochondrial metabolic energy to coordinate the immune response and nerve regeneration are lacking. Here, a ligand‐screened cerium‐based metal‐organic framework (MOF) with better ROS scavenging and drug‐loading abilities is encapsulated with polydopamine after loading creatine to obtain microcapsules (Cr/Ce@PDA nanoparticles), which reverse the energy deficits in both macrophages and neuronal cells by combining ROS scavenging and energy supplementation. It reprogrames inflammatory macrophages to the proregenerative phenotype via the succinate/HIF‐1α/IL‐1β signaling axis. It also promotes the regeneration and differentiation of neural cells by activating the mTOR pathway and paracrine function of macrophages. In vivo experiments further confirm the effect of the microcapsules in regulating early ROS‐inflammation positive‐feedback chain reactions and continuously promoting nerve regeneration. This study provides a new strategy for correcting mitochondrial energy deficiency in the immune response and nerve regeneration following SCI.
Mineral phosphorus fertilization for silage corn in manured soils in the Fraser Valley, Canada
Authors: Nyamaizi Sylvia , Messiga Aimé J. , Cornelis Jean‐Thomas , Smukler Sean M. , Cade‐Menun Barbara J. 
Published: December 2023

AbstractEfficient management of fertilizer phosphorus (P) is crucial for enhanced resilience of agro‐ecosystems. We assessed five rates (0, 5, 10, 15, and 20 kg P ha−1) of starter P fertilizer on silage corn (Zea mays L) yield in high‐P manured soils at eight sites in 2020 and 2021 in the Fraser Valley, Canada, monitoring soil phosphate concentrations using anion exchange membranes (AEM‐P). At the V3 and V6 (3‐ and 6‐leaf) stages, corn dry matter (DM) weight response to starter P was not significant, except at one site where the critical rate was 5 kg P ha−1. At maturity, corn DM yields were in the optimum provincial range (20–25 Mg ha−1), with the exception of two sites, one with low initial soil P concentrations and the other with waterlogged soils. These results indicate that during the growing season, phosphate supply from manure application alone was sufficient for silage corn growth. Root length and diameter were not affected by starter fertilizer, while root surface area, volume, and root DM weight decreased with increasing starter fertilizer at the V3 stage in 2020. In addition, AEM‐P increased with starter P only during the first week after application. We conclude that starter fertilizer P, at any application rate, in high‐P manured soils does not improve silage corn yield; farmers applying manure at plowing in soils with high P concentrations can reduce or eliminate starter fertilizer P without impacting silage corn yields, decreasing reliance on off‐farm P inputs, and reducing potential P loss to the environment.
Asymmetric Synthesis of Arboduridine
Authors: Yang Rui , Zhou Zeyu , Jiang Huanfeng , Kam Toh‐Seok , Chen Kai , Ma Zhiqiang 
Published: December 2023

AbstractThe first asymmetric total synthesis of the monoterpenoid indole alkaloid arboduridine has been accomplished. The tricyclic A/B/D ring system was constructed by an enantioselective Michael reaction followed by intramolecular nucleophilic addition. Intramolecular α‐amination of a ketone forged the piperidine ring, while a Horner–Wadsworth–Emmons (HWE) reaction was used to form the pyrrolidine ring. A reduction cyclization cascade led to formation of the tetrahydrofuran ring.
Quest for high performance carbon capture membranes: Fabrication of SAPO‐34 and CNTs‐doped polyethersulfone‐based mixed‐matrix membranes
Authors: Nawaz Sidra , Sarfraz Muhammad , Qaiser Asif Ali , Alomar Muneerah , Gouadria Soumaya , BaQais Amal Ali 
Published: December 2023

AbstractGas separation process is an effective method for capturing and removing CO2 from post‐combustion flue gases. Due to their various essential properties such as ability to improve process efficiency, polymeric membranes are known to dominate the market. Trade‐off between gas permeability and selectivity through membranes limits their separation performance. In this study, solution casting cum phase separation method was utilized to create polyethersulfone‐based composite membranes doped with carbon nanotubes (CNTs) and silico aluminophosphate (SAPO‐34) as nanofiller materials. Membrane properties were then examined by performing gas permeation test, chemical structural analysis and optical microscopy. While enhancing membranes CO2 permeance, SAPO‐34 and CNTs mixture improved their CO2/N2 selectivity. By carefully adjusting membrane casting factors such as filler loadings. Using Taguchi statistical analysis, their carbon capture efficiency was improved. The improved mixed‐matrix membrane with loading of 5 wt% CNTs and 10 wt% SAPO‐34 in PES showed highly promising separation performance with a CO2 permeability of 319 Barrer and an ideal CO2/N2 selectivity of 12, both of which are within the 2008 Robeson upper bound. A better mixed‐matrix membrane with outstanding CO2/N2 selectivity and CO2 permeability was produced as a result of the synergistic effect of adding two types of fillers in optimized loading.
The social behaviour of the common bottlenose dolphin Tursiops truncatus (Montagu, 1821) in the coastal waters of Lampedusa Island (Strait of Sicily, Italy)
Authors: Corrias Valentina , Moulins Aurélie , Filiciotto Francesco , Giardina Fabio 
Published: December 2023

Abstract

Research on social structure and residency provides important information on the dynamics of a population, improving knowledge of the species' behaviour and ecology. This study investigated the social network, site fidelity, and residency patterns of common bottlenose dolphins (Tursiops truncatus) off Lampedusa Island.
Direct visual detection and photo‐identification methods were used to collect data during 124 boat‐based surveys conducted from 2013 to 2020. A total of 117 groups (mean size 4.5 ± 3.3) were sighted; 73 well‐marked animals were identified, of which 59% were resighted over the years.
The estimate of social differentiation was 0.72 (SE = 0.07), suggesting differentiated social groups within the community. Data were somewhat representative of the true social system, as the correlation coefficient was close to 0.4. However, the half‐weight index averaged 0.07 (±0.03), indicating individuals' low tendency to associate. Five social clusters were identified with strong relationships between individuals within each cluster, in which 94% of maximum association indices were ≥0.4. The data also highlighted preferred and avoided associations and stable relationships. The removal of individuals with the highest values of strength and eigenvector centrality from the network did not affect its connectivity, suggesting inherent robustness.
Despite the different levels of site fidelity among individuals, the results indicated rather high levels of yearly sighting rate. Temporary migration into and out of the area shown by this study indicates that Lampedusa coastal waters are an important, regularly used bottlenose dolphin habitat.
These results suggest extensive ranging behaviour, which implies the need for networking between institutions and organizations from the various states bordering the Strait of Sicily to address conservation efforts and inform regional management of the Mediterranean bottlenose dolphin population.
HS‐10352 in hormone receptor‐positive, HER2‐negative advanced breast cancer: A phase 1 dose‐escalation trial
Authors: Ouyang Quchang , Wang Ying , Zhang Jian , Wu Qiong , Wei Hongying , Li Chuan , Qian Xiaoling , Hu Xichun 
Published: December 2023

AbstractBackgroundApproximately 40% of patients with hormone receptor (HR)‐positive and human epidermal growth factor receptor 2 (HER2)‐negative advanced breast cancer (ABC) exhibit PIK3CA mutations.AimsThis study aims to evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of HS‐10352, a selective PI3Kα inhibitor, in this patient population.Materials and MethodsConducted as a phase 1 dose‐escalation trial, HS‐10352 was administered orally once‐daily (QD) at dose levels of 2, 4, 6, and 8 mg. The primary endpoints were dose‐limiting toxicity (DLT) and the maximum tolerated dose (MTD). This study is registered at ClinicalTrials.gov (NCT04631835).ResultsBetween August 2020 and March 2022, a total of 18 female patients were enrolled. DLT, manifested as hyperglycemia, occurred in two patients in the 8 mg QD group, establishing an MTD of 6 mg QD. The most common treatment‐related adverse events were hyperglycemia (88.9%) and weight loss (61.3%). In the 6 mg QD group, four patients (66.7%) had a partial response (PR), and one (16.7%) had stable disease (SD). Among the four patients with PIK3CA mutated tumors in this dosage group, three (75.0%) had PR and one (25.0%) had SD. The median progression‐free survival was not reached (95% confidence interval, 11.1‐NA).Discussion and ConclusionHS‐10352 at 6 mg QD was well‐tolerated in patients with HR‐positive, HER2‐negative ABC, and showed preliminary antitumor activity in patients with PIK3CA mutated tumors. These findings support the further clinical development of HS‐10352.
Climate warming increases insect‐driven seed removal of two elaiosome‐bearing invasive thistle species
Authors: Drees Trevor H. , Shea Katriona 
Published: December 2023

AbstractAnts and other insects are often a source of localized secondary dispersal for wind‐dispersed plants and thus play an important ecological role in their spatial dynamics, but there is limited information on how climate change will affect such dispersal processes. Here, we use field experiments to investigate how climate warming affects seed removal, as this initiation of movement represents the first step in insect‐driven secondary dispersal. Our results indicate that for the invasive thistles Carduus nutans and Carduus acanthoides, increased growing temperature influences seed attractiveness to insect dispersers, with seeds from maternal plants grown at temperatures 0.6°C above ambient removed by insect dispersers at higher rates than their unwarmed counterparts. We also observe that seed elaiosomes in these two species play an important role in dispersal, as seeds without elaiosomes were significantly less likely to be removed over the same period. Significant interactions between elaiosome presence/absence and warming treatment were also observed, though only for C. acanthoides, with the boost in seed removal from warming dampened when the elaiosome was present compared to when it was absent. These findings provide evidence that climate warming may alter aspects of dispersal such as seed removal by secondary dispersers, with potential ramifications for dispersal in future climates since seed‐bearing plants around the world may be subject to increased growing temperatures, and many of these plant species bear elaiosomes and experience seed dispersal by insects.
Mapping landscape evolution in 3D: Climate change, natural hazard and human settlements across the 1618 Piuro landslide in the Italian Central Alps
Authors: Pigazzi Enrico , Bersezio Riccardo , Marotta Federica , Apuani Tiziana 
Published: December 2023

AbstractNatural and anthropogenic mountain landscapes coevolve responding on different temporal scales to climate changes and geodynamics by a series of increments that cause the dynamic association of morphological stabilization surfaces, stratigraphic units and landforms. Understanding the incremental history of palimpsest landscapes helps to recognize and forecast the effects of climate change on the sensitive mountain environments, contributes to archaeological and historical reconstruction and supports management strategies for natural risks prevention and mitigation. The Italian Bregaglia Valley provides an excellent site to unravel the recent/historical increments of evolution of landforms and human settlement, permitting to map the paleo‐digital terrain models (DTMs) corresponding to the relevant landscape turning points. After the last de‐glaciation, two large‐scale landslides reshaped the valley floor, both predisposed by deep‐seated gravitational slope deformations and one surely triggered by intense rainfalls. The most recent and impacting event buried in 1618 the rich border town of Piuro, the ancient one occurred in the same area at least 1.5 ka before. Combining stratigraphic, geomorphological, topographic, archaeological and historical data, we drew the paleo‐DTMs of the pre‐ and post‐1618 settings of Piuro, sketching the landscape evolution. Since two millennia, human settlements took advantage of the decadal to secular most stable surfaces, represented by the inactive lobes of debris‐flow fans, the highest trunk river terraces and the top of humps formed by the ancient landslide body in the valley centre. Stratigraphic relationships, archaeological findings and age determinations show that both landslides diverted the trunk river and covered the existing fan lobes. On a secular timescale, fan progradation and trunk river terracing buried and reworked both the landslide bodies. The paleo‐DTMs show their original areal extent and permit to compute their volume and to sketch the setting of the buried Piuro settlements, drawing the changes of the Mera trunk river course and the chronology of activity of the lateral debris‐flow fan lobes.
Classic Hodgkin lymphoma
Authors: Kahn Justine , Dabaja Bouthaina , Wu Susan , Kelly Kara , Berkahn Leanne , Pavlovsky Astrid , Sureda Anna , LaCasce Ann 
Published: December 2023

AbstractClassic Hodgkin lymphoma (HL) is rare disease, with an incidence of approximately 85,000 patients globally per year and a predilection for adolescents and young adults (ages 15–39). Since the introduction of combination chemotherapy in the 1960's and radiation dating back to the early 1900's, therapeutic options and by extension, clinical outcomes have improved dramatically with 5‐year overall survival (OS) approaching 90% today. [1](#ref‐0001) Advances in understanding HL biology have additionally facilitated development of targeted agents and immunotherapy which have further improved short and long‐term outcomes. Despite continued improvements in up‐front and salvage therapy, long‐term survivors of HL experience several treatment‐associated late toxicities, thus, along with efforts to improve therapeutic efficacy, efforts to reduce late effects remain a high‐priority in the field.
Polo‐like kinase 1 inhibitor NMS‐P937 represses nasopharyngeal carcinoma progression via induction of mitotic abnormalities
Authors: Gao Jing , Huang Weirong , Zhao Senxia , Wang Rong , Wang Zhilin , Ye Juanping , Lin Lie , Cai Weifeng , Mi Yanjun 
Published: December 2023

AbstractPolo‐like kinase 1 (PLK1) inhibitor NMS‐P937 is a targeted therapeutic agent with good preclinical efficacy in various human cancers, and its therapeutic effect on nasopharyngeal carcinoma (NPC) remains to be determined. Here, to explore biological activity of NMS‐P937 in NPC, multiple types of NPC cells were utilized. We tested IC50 values, carried out flow cytometry, western blot analysis analysis, immunofluorescence, and constructed subcutaneous xenograft mouse models. We found that treatment with NMS‐P937 increased the proportion of G2/M phase NPC cells, where CyclinB1 expression was upregulated and CyclinE1 expression was downregulated. Besides, NMS‐P937 treatment‐induced NPC cell apoptosis with increased cleavage of PARP and caspase‐3. Mechanistically, NMS‐P937 treatment led to aberrant mitosis, causing increased reactive oxygen species (ROS) levels. ROS scavenger N‐acetylcysteine partially reversed ROS levels induced by NMS‐P937. Furthermore, NMS‐P937 administration restrained NPC xenografts growth in nude mice. Overall, NMS‐P937 suppressed NPC cell proliferation and increased ROS levels, causing cell cycle abnormalities and apoptosis. NMS‐P937 holds great promise as a therapeutic agent for treating nasopharyngeal carcinoma.