bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reference Ranges for Regional Cerebral Oxygen Saturation with Masimo O3 after Birth and Differences with Other Devices
Authors: Carnicero Luis Bachiller , Carbonero Sonia Caserío 
Published: January 2024

Objective Cerebral oximetry using near-infrared spectroscopy (NIRS) is a noninvasive optical technology widely used in neonatology. The present study aimed to define reference ranges for cerebral tissue oxygen saturation (crSO2) with a new four-wavelength NIRS device, Masimo O3 oximeter, during immediate transition after birth and compare values with those obtained previously with NIRO 200NX®.
Study Design This was a prospective observational study using Masimo O3 device to measure crSO2 and regional cerebral fractional tissue oxygen extraction (cFTOE) in healthy term newborns delivered by primary cesarean section, during the 15 minutes after cord clamping. The neonates who required any medical support were excluded. The NIRS sensor was placed on the right forehead. Peripheral oxygen saturation and heart rate were continuously measured by pulse oximetry. Previous studies which established centiles for crSO2 with NIRO 200NX were used for comparison.
Results A total of 44 newborns were included. The median crSO2 and cFTOE (interquartile range) at 2, 5, and 7 minutes was 54% (49–54), 71% (64–86), and 79% (73–84) and 0,25 (0,18–0,33), 0,19 (0,15–0,23), and 0,16 (0,12–0,21), respectively, with no further changes afterwards. The crSO2 measurements were significantly higher with Masimo O3 compared with NIRO-200NX.
Conclusion The present observational study presented reference ranges for crSO2 and cFTOE measured with Masimo O3 oximeter during the immediate neonatal transition. Values obtained with O3 were higher than those obtained with other oximeters. For this reason, crSO2 is device-specific so there must be known reference values for each oximeter to define therapeutic interventions based on crSO2 and assess cerebral oxygenation in clinical studies.
Key Points
ADAMTS13 or Caplacizumab Reduces the Accumulation of Neutrophil Extracellular Traps and Thrombus in Whole Blood of COVID-19 Patients under Flow
Authors: Yada Noritaka , Zhang Quan , Bignotti Antonia , Ye Zhan , Zheng X. Long 
Published: January 2024

Background Neutrophil NETosis and neutrophil extracellular traps (NETs) play a critical role in pathogenesis of coronavirus disease 2019 (COVID-19)-associated thrombosis. However, the extents and reserve of NETosis, and potential of thrombus formation under shear in whole blood of patients with COVID-19 are not fully elucidated. Neither has the role of recombinant ADAMTS13 or caplacizumab on the accumulation of NETs and thrombus in COVID-19 patients' whole blood under shear been investigated.
Methods Flow cytometry and microfluidic assay, as well as immunoassays, were employed for the study.
Results We demonstrated that the percentage of H3Cit + MPO+ neutrophils, indicative of NETosis, was dramatically increased in patients with severe but not critical COVID-19 compared with that in asymptomatic or mild disease controls. Upon stimulation with poly [I:C], a double strain DNA mimicking viral infection, or bacterial shigatoxin-2, the percentage of H3Cit + MPO+ neutrophils was not significantly increased in the whole blood of severe and critical COVID-19 patients compared with that of asymptomatic controls, suggesting the reduction in NETosis reserve in these patients. Microfluidic assay demonstrated that the accumulation of NETs and thrombus was significantly enhanced in the whole blood of severe/critical COVID-19 patients compared with that of asymptomatic controls. Like DNase I, recombinant ADAMTS13 or caplacizumab dramatically reduced the NETs accumulation and thrombus formation under arterial shear.
Conclusion Significantly increased neutrophil NETosis, reduced NETosis reserve, and enhanced thrombus formation under arterial shear may play a crucial role in the pathogenesis of COVID-19-associated coagulopathy. Recombinant ADAMTS13 or caplacizumab may be explored for the treatment of COVID-19-associated thrombosis.
A Simple and Efficient Approach for the Synthesis of Aryl-3-(trifluoromethyl)-1H-1,2,4-triazol-5(4H)-one Derivatives
Authors: Darehkordi Ali , Kazemi Elham , Zeinali Najmeh 
Published: January 2024

AbstractIn this work, a series of 4-aryl-3-(trifluoromethyl)-1H-1,2,4-triazol-5(4H)-one derivatives is synthesized through nucleophilic intramolecular cyclization reactions of ethyl 2-(2,2,2-trifluoro-1-(arylimino)ethyl)hydrazine-1-carboxylate intermediates, which are themselves prepared in high yields via reactions of ethyl chloroformate and N-aryl-2,2,2-trifluoroacetimidoyl chloride derivatives. Some of the merits of the reported procedure are an operationally simple and concise method, the ready availability of starting materials, excellent product yields, no formation of harmful by-products and easy purification of the products.
Repercussions of the Emergency neurological life support on scientific literature: a bibliometric study
Authors: Ramos Miguel Bertelli , Rech Matheus Machado , Telles João Paulo Mota , Moraes Willian Medeiros , Teixeira Manoel Jacobsen , Figueiredo Eberval Gadelha 
Published: January 2024

Abstract
Background In 2012, the Neurocritical Care Society launched a compilation of protocols regarding the core issues that should be addressed within the first hours of neurological emergencies – the Emergency neurological life support (ENLS).
Objective We aim to evaluate this repercussion through a bibliometric analysis.
Methods We searched Scopus on October 2022 for articles mentioning ENLS. The following variables were obtained: number of citations; number of citations per year; number of publications per year; year of publication; research type; research subtype; country of corresponding author and its income category and world region; journal of publication and its 5-year impact factor (IF); and section where ENLS appeared.
Results After applying eligibility criteria, we retrieved 421 articles, published from 2012 to 2022. The mean number of citations per article was 17.46 (95% Confidence Interval (CI) = 8.20–26.72), while the mean number of citations per year per article was 4.05 (95% CI = 2.50–5.61). The mean destiny journal 5-year IF was 5.141 (95% CI = 4.189–6.093). The majority of articles were secondary research (57.48%; n = 242/421) of which most were narrative reviews (71.90%; n = 174/242). High-Income countries were the most prominent (80.05%; n = 337/421 articles). There were no papers from low-income countries. There were no trials or systematic reviews from middle-income countries.
Conclusion Although still low, the number of publications mentioning ENLS is increasing. Articles were mainly published in journals of intensive care medicine, neurology, neurosurgery, and emergency medicine. Most articles were published by authors from high-income countries. The majority of papers were secondary research, with narrative review as the most frequent subtype.
Hepatocellular Carcinoma from a Hepatologist's Perspective
Authors: Roldan Giovanni A. , Blomker Jacquelin , Aby Elizabeth S. 
Published: January 2024

AbstractHepatocellular carcinoma (HCC), the most common type of primary liver cancer, represents a growing health challenge worldwide. The incidence of HCC is rising, which, in turn, has led to a corresponding increase in the associated number of deaths. HCC will become the third leading cause of cancer-related deaths in the United States by 2030. HCC usually develops in the setting of chronic liver disease. Individuals at increased risk of HCC are recommended to undergo surveillance with ultrasound every 6 months along with serum α-fetoprotein testing. Computed tomography (CT) and magnetic resonance imaging (MRI) are considered alternatives based on specific patient factors. Lesions suspicious for HCC are recommended to undergo a diagnostic testing, which includes contrast-enhanced multiphase CT or MRI and liver biopsy when findings are indeterminate. The Barcelona Clinic Liver Cancer prognosis and treatment strategy is the most used assessment for patients with HCC (Fig. 2). Curative therapies include resection, liver transplantation, and ablation. Locoregional therapies, such as transarterial chemoembolization and radioembolization, can be used for patients with intermediate-stage HCC. For patients with advanced-stage HCC, systemic therapy is often used. This review aims to provide an overview of HCC from a hepatologist's perspective, including epidemiology, screening, surveillance, diagnosis, and management.
Anaesthesia for Cleft Lip and Palate Operations: A Modification of Orotracheal Connection—Report on 1,500 Patients
Authors: Guha Dr. B. 
Published: January 2024

SummaryDevelopment of different types of endotracheal tubes and connections used for cleft lip and palate operations, their merits and demerits are discussed. A further attempt at modification of these tubes and connections in respect of cleft lip and palate operations is discussed. A modification of endotracheal connection which satisfied all the requirements of an set up for operation on cleft lip and palate is described.
Key comparison BIPM.RI(I)-K8 of high dose-rate 192Ir brachytherapy standards for reference air kerma rate of the PTB and the BIPM
Authors: Kessler C , Behrens R , Kasper A , Grote F 
Published: January 2024

Main text
An indirect comparison of the standards for reference air kerma rate for 192Ir high dose rate (HDR) brachytherapy sources of the Physikalisch-Technische Bundesanstalt (PTB), Germany, and of the Bureau International des Poids et Mesures (BIPM) was carried out at the PTB in May 2023. The comparison result, based on the calibration coefficients for a transfer standard and expressed as a ratio of the PTB and the BIPM standards for reference air kerma rate, is 1.0022 with a combined standard uncertainty of 0.0101.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Key comparison BIPM.RI(I)-K7 of the air-kerma standards of the BFKH, Hungary, and the BIPM in mammography x-rays
Authors: Kessler C , Burns D , Finta V 
Published: January 2024

Main text
A key comparison has been made between the air-kerma standards of the BFKH, Hungary, and the BIPM in mammography x-ray beams. The results show the standards to agree at the level of the expanded uncertainty of the comparison of 9.2 parts in 103. The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
The non-linear perturbation of a black hole by gravitational waves. III. Newman–Penrose constants
Authors: Frauendiener J , Goodenbour A , Stevens C 
Published: January 2024

Abstract
In this paper we continue our study of the non-linear response of a Schwarzschild black hole to an ingoing gravitational wave by computing the Newman–Penrose (NP) constants. The NP constants are five complex, supertranslation-invariant quantities defined on null infinity

I

+

and although put forward in the 60’s, they have never been computed in a non-stationary setting. We accomplish this through a numerical implementation of Friedrich’s generalized conformal field equations whose semi-global evolution yields direct access to

I

+

. The integral expressions for the NP constants as given originally are expressed in a general gauge to enable their computation from numerically generated data. Canonical methods of fixing inherent degrees of freedom in their definitions are discussed. The NP expressions are then computed for a variety of different ingoing wave profiles in axisymmetry, and then with no symmetry assumptions in a general

3
+
1

setting for which all five complex quantities are non-zero. We discuss the consequence of the (numerical) constancy of the NP expressions for the (non)-smoothness of null-infinity.
EVStabilityNet: predicting the stability of star clusters in general relativity
Authors: Straub Christopher , Wolfschmidt Sebastian 
Published: January 2024

AbstractWe present a deep neural network which predicts the stability of isotropic steady states of the asymptotically flat, spherically symmetric Einstein–Vlasov system in Schwarzschild coordinates. The network takes as input the energy profile and the redshift of the steady state. Its architecture consists of a U-Net with a dense bridge. The network was trained on more than ten thousand steady states using an active learning scheme and has high accuracy on test data. As first applications, we analyze the validity of physical hypotheses regarding the stability of the steady states.
β-Ga2O3 nanotube arrays for high-performance self-powered ultraviolet photoelectrochemical photodetectors
Authors: Ding Shan , Chen Kai , Xiu Xiangqian , Shao Pengfei , Xie Zili , Tao Tao , Liu Bin , Chen Peng , Chen Dunjun , Zhang Rong , Zheng Youdou 
Published: January 2024

Abstract
Self-powered ultraviolet (UV) photodetectors (PDs) are critical for future energy-efficient optoelectronic systems due to their low energy consumption and high sensitivity. In this paper, the vertically aligned β-Ga2O3 nanotube arrays (NTs) have been prepared on GaN/sapphire substrate by the thermal oxidation process combined with the dry etching technology, and applied in the UV photoelectrochemical photodetectors (PEC-PDs) for the first time. Based on the large specific surface area of β-Ga2O3 NTs on GaN/sapphire substrates and the solid/liquid heterojunction, the PEC-PDs exhibit excellent self-powered characteristics under 255 nm (UVA) and 365 nm (UVC) light illumination. Under 255 nm (365 nm) light illumination, the maximum responsivity of 49.9 mA W−1 (32.04 mA W−1) and a high detectivity of 1.58 × 1011 Jones (1.01 × 1011 Jones) were achieved for the β-Ga2O3 NTs photodetectors at 0 V bias. In addition, the device shows a fast rise/decay time of 8/4 ms (4/2 ms), which is superior to the level of the previously reported self-powered UV PEC-PDs. This high-performance PEC-PD has potential applications in next-generation low-energy UV detection systems.
Biomass carbon and Ti2C3MXene quantum dots as ratiometric fluorescent probes for sensitive detecting malachite green in fish sample
Authors: Wang Xiaoyan , Luo Xiaoling , Zou Pintian , Lv Yi-ju , Kong Xiangfei , Huang Yue , Liu Zheng , Han Guo-Cheng 
Published: January 2024

Abstract
A visual detection method for malachite green (MG) in food was established based on ‘double-response-OFF’ ratiometric fluorescent paper-based sensor. Biomass carbon quantum dots (BCQDs) using broad bean shell, and Ti3C2MXene quantum (MQDs) dots modified by ethylenediamine were synthesized by solvothermal method. The MG and two kinds of quantum dots could undergo static quenching, and the fluorescence color of two kinds of quantum dots gradually changed from red to blue, eventually the fluorescence was quenched, and the pattern had a two-stage linear relationship using fluorescent spectrofluorometer in the range of 0.1–140.0 μM and the detection limit of 0.07 μM. On this basis, a BCQDs/MQDs ratiometric fluorescence paper-based sensor was constructed and applied to fish sample. Through mobile phone software-Color recognizer, RGB values of fluorescent paper-based sensor at various concentrations of MG were extracted. The results showed that MG concentration was linearly correlated with R’ value of RGB in the range of 20.0–140.0 μM with 16.5 μM detection limit. The method had been applied to the determination of canned fish and fresh basa fish samples, and the recovery rates were 97.33%–108.93% and 96.04%–117.97%, respectively. It proved that the ratiometric fluorescent paper-based sensor could be used for the rapid visual quantitative detecting MG in real samples.
Large-area, size-controlled and transferable graphene oxide-metal films for humidity sensor
Authors: Zhu Xiaobin , Zhou Zhengcun , Zhang Jinlei , Wu Shuyi 
Published: January 2024

Abstract
The lack of low-cost methods to synthesize large-area graphene-based materials is still an important factor that limits the practical application of graphene devices. Herein, we present a facile method for producing large-area graphene oxide-metal (GO–M) films, which are size controllable and transferable. The sensor constructed using the GO–M film exhibited humidity sensitivity while being unaffected by pressure. The relationship between the sensor’s resistance and relative humidity followed an exponential trend. The GO–Mg sensor was the most sensitive among all the tested sensors. The facile synthesis of GO–M films will accelerate the widespread utilization of graphene-based materials.
Discrete residual diffusion model for high-resolution prostate MRI synthesis
Authors: Han Zhitao , Huang Wenhui 
Published: January 2024

Abstract

Objective. High-resolution magnetic resonance imaging (HR MRI) is an effective tool for diagnosing PCa, but it requires patients to remain immobile for extended periods, increasing chances of image distortion due to motion. One solution is to utilize super-resolution (SR) techniques to process low-resolution (LR) images and create a higher-resolution version. However, existing medical SR models suffer from issues such as excessive smoothness and mode collapse. In this paper, we propose a novel generative model avoiding the problems of existing models, called discrete residual diffusion model (DR-DM). Approach. First, the forward process of DR-DM gradually disrupts the input via a fixed Markov chain, producing a sequence of latent variables with increasing noise. The backward process learns the conditional transit distribution and gradually match the target data distribution. By optimizing a variant of the variational lower bound, training diffusion models effectively address the issue of mode collapse. Second, to focus DR-DM on recovering high-frequency details, we synthesize residual images instead of synthesizing HR MRI directly. The residual image represents the difference between the HR and LR up-sampled MR image, and we convert residual image into discrete image tokens with a shorter sequence length by a vector quantized variational autoencoder (VQ-VAE), which reduced the computational complexity. Third, transformer architecture is integrated to model the relationship between LR MRI and residual image, which can capture the long-range dependencies between LR MRI and the synthesized imaging and improve the fidelity of reconstructed images. Main results. Extensive experimental validations have been performed on two popular yet challenging magnetic resonance image super-resolution tasks and compared to five state-of-the-art methods. Significance. Our experiments on the Prostate-Diagnosis and PROSTATEx datasets demonstrate that the DR-DM model significantly improves the signal-to-noise ratio of MRI for prostate cancer, resulting in greater clarity and improved diagnostic accuracy for patients.
Partial volume correction of PET image data using geometric transfer matrices based on uniform B-splines
Authors: Mandeville Joseph B , Efthimiou Nikos , Weigand-Whittier Jonah , Hardy Erin , Knudsen Gitte M , Jørgensen Louise M , Chen Yin-Ching I 
Published: January 2024

Abstract

Objective. Most methods for partial volume correction (PVC) of positron emission tomography (PET) data employ anatomical segmentation of images into regions of interest. This approach is not optimal for exploratory functional imaging beyond regional hypotheses. Here, we describe a novel method for unbiased voxel-wise PVC. Approach. B-spline basis functions were combined with geometric transfer matrices to enable a method (bsGTM) that provides PVC or alternatively provides smoothing with minimal regional crosstalk. The efficacy of the proposed method was evaluated using Monte Carlo simulations, human PET data, and murine functional PET data. Main results. In simulations, bsGTM provided recovery of partial volume signal loss comparable to iterative deconvolution, while demonstrating superior resilience to noise. In a real murine PET dataset, bsGTM yielded much higher sensitivity for detecting amphetamine-induced reduction of [11C]raclopride binding potential. In human PET data, bsGTM smoothing enabled increased signal-to-noise ratios with less degradation of binding potentials relative to Gaussian convolution or non-local means. Significance. bsGTM offers improved performance for PVC relative to iterative deconvolution, the current method of choice for voxel-wise PVC, especially in the common PET regime of low signal-to-noise ratio. The new method provides an anatomically unbiased way to compensate partial volume errors in cases where anatomical segmentation is unavailable or of questionable relevance or accuracy.
Setup and characterisation according to NEMA NU 4 of the phenoPET scanner, a PET system dedicated for plant sciences
Authors: Hinz Carsten , Jahnke Siegfried , Metzner Ralf , Pflugfelder Daniel , Scheins Jürgen , Streun Matthias , Koller Robert 
Published: January 2024

Abstract

Objective. The phenoPET system is a plant dedicated positron emission tomography (PET) scanner consisting of fully digital photo multipliers with lutetium–yttrium oxyorthosilicate crystals and located inside a custom climate chamber. Here, we present the setup of phenoPET, its data processing and image reconstruction together with its performance. Approach. The performance characterization follows the national electrical manufacturers association (NEMA) standard for small animal PET systems with a number of adoptions due to the vertical oriented bore of a PET for plant sciences. In addition temperature stability and spatial resolution with a hot rod phantom are addressed. Main results. The spatial resolution for a 22Na point source at a radial distance of 5 mm to the center of the field-of-view (FOV) is 1.45 mm, 0.82 mm and 1.88 mm with filtered back projection in radial, tangential and axial direction, respectively. A hot rod phantom with 18F gives a spatial resolution of up to 1.6 mm. The peak noise-equivalent count rates are 550 kcps @ 35.08 MBq, 308 kcps @ 33 MBq and 45 kcps @ 40.60 MBq for the mouse, rat and monkey size scatter phantoms, respectively. The scatter fractions for these phantoms are 12.63%, 22.64% and 55.90%. We observe a peak sensitivity of up to 3.6% and a total sensitivity of up to S

A,tot
= 2.17%. For the NEMA image quality phantom we observe a uniformity of %STD = 4.22% with ordinary Poisson maximum likelihood expectation-maximization with 52 iterations. Here, recovery coefficients of 0.12, 0.64, 0.89, 0.93 and 0.91 for 1 mm, 2 mm, 3 mm, 4 mm and 5 mm rods are obtained and spill-over ratios of 0.08 and 0.14 for the water-filled and air-filled inserts, respectively. Significance. The phenoPET and its laboratory are now in routine operation for the administration of [11C]CO2 and non-invasive measurement of transport and allocation of 11C-labelled photoassimilates in plants.