bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atorvastatin Effect on COVID-19 Outcomes: A Propensity Score
Matched Study on Hospitalized Patients
Authors: Pourhoseingholi Mohamad Amin , Yazdani Omid , Azizmohammad Looha Mehdi , Safavi-Naini Seyed Amir Ahmad , Esbati Romina , Ilkhani Saba , Taraghikhah Nazanin , Hatamabadi Hamidreza , Sadeghi Amir , Heidari Kamran , Namazi Negarsadat , Asadimanesh Naghmeh , Hatari Saba , Shahrokh Shabnam , Solhpour Ali , Jamialahmadi Tannaz , Santos Raul D. , Sahebkar Amirhossein 
Published: January 2024

Background:
This study investigated the association of atorvastatin use on
survival, need for intensive care unit (ICU) admission, and length of hospital stay (LOS)
among COVID-19 inpatients.

Materials and Methods:
A retrospective study was conducted between March 20th,
2020, and March 18th, 2021, on patients with confirmed COVID-19 admitted to three
hospitals in Tehran, Iran. The unadjusted and adjusted effects of atorvastatin on
COVID-19 prognosis were investigated. Propensity score matching (PSM) was used to
achieve a 1:1 balanced dataset with a caliper distance less than 0.1 and the nearest neighbor
method without replacement.

Results::
Of 4322 COVID-19 patients, 2136 (49.42%) were treated with atorvastatin. After
PSM, 1245 atorvastatin inpatients and 1245 controls were included with a median
age of 62.0 (interquartile range [IQR]: 51.0, 76.0) and 63.0 (IQR: 51.0, 75.0) years, respectively.
The standardized mean differences were less than 0.1 for all confounders,
suggesting a good covariate balance. The use of atorvastatin was associated with decreased
COVID-19 mortality (HR: 0.80; 95% CI: 0.68-0.95), whereas no relationship
was found between atorvastatin and the need for ICU admission (HR: 1.21; 95% CI:
0.99-1.47). LOS was significantly higher in the atorvastatin cohort than controls (Atorvastatin
vs. others: 7 [5, 11] vs. 6 [4, 10] days; p = 0.003). The survival rate was higher
in combination therapy of atorvastatin plus enoxaparin than in those who received atorvastatin
alone (p-value=0.001).

Conclusion::
Atorvastatin may reduce the risk of COVID-19 in-hospital mortality and
could be a beneficial option for an add-on therapy. Randomized trials are warranted to
confirm the results of the current observational studies.
Genetic and Epigenetic Determinants of COVID-19 Susceptibility: A Systematic Review
Authors: Gasmi Amin , Kassym Laura , Menzel Alain , Anzar Wajiha , Dadar Maryam , Semenova Yuliya , Arshad Mehreen , Bihunyak Tetyana , Meguid Nagwa Abdel , Peana Massimiliano , Bekbergenova Zhanagul , Bjørklund Geir 
Published: January 2024

Background:
The molecular mechanisms regulating coronavirus pathogenesis
are complex, including virus-host interactions associated with replication and innate
immune control. However, some genetic and epigenetic conditions associated with comorbidities
increase the risk of hospitalization and can prove fatal in infected patients.
This systematic review will provide insight into host genetic and epigenetic factors that
interfere with COVID-19 expression in light of available evidence.

Methods:
This study conducted a systematic review to examine the genetic and epigenetic
susceptibility to COVID-19 using a comprehensive approach. Through systematic
searches and applying relevant keywords across prominent online databases, including
Scopus, PubMed, Web of Science, and Science Direct, we compiled all pertinent papers
and reports published in English between December 2019 and June 2023.

Results:
The findings reveal that the host's HLA genotype plays a substantial role in determining
how viral protein antigens are showcased and the subsequent immune system
reaction to these antigens. Within females, genes responsible for immune system regulation
are found on the X chromosome, resulting in reduced viral load and inflammation
levels when contrasted with males. Possessing blood group A may contribute to an increased
susceptibility to contracting COVID-19 as well as a heightened risk of mortality
associated with the disease. The capacity of SARS-CoV-2 involves inhibiting the antiviral
interferon (IFN) reactions, resulting in uncontrolled viral multiplication.

Conclusion:
There is a notable absence of research into the gender-related predisposition
to infection, necessitating a thorough examination. According to the available literature,
a significant portion of individuals affected by the ailment or displaying severe ramifications
already had suppressed immune systems, categorizing them as a group with elevated
risk.
Optimization and Effect of Substituents on the Transformation of
3-(Substituted acetoxy)azetidin-2-ones to Chiral 3-Hydroxyazetidin-2-ones,
Molecular Docking and Enantiomeric Excess Determination
Authors: Bhalla Aman , Modi Garima , Kumar Pankaj , Kaur Jaswinder , Berry Shiwani , Bari Shamsher S. , Banik Bimal K. 
Published: January 2024

Abstract:
The enantioselective synthesis of chiral cis-3-hydroxyazetidin-2-ones mediated by Porcine
Pancreatic Lipase (PPL) via hydrolysis of cis-3-(chloro acetoxy) azetidin-2-ones in the presence of a
phosphate buffer (0.1M, pH = 7.2) in acetonitrile at a temperature range of 25-35 °C was optimized.
Under the optimized reaction conditions, the influence of various electron
withdrawing/donating/neutral groups on ester functionality of cis-3-(substituted acetoxy)azetidin-2-
ones towards hydrolysis was extensively studied, and the bromoacetoxy, propanyloxy, and
formyloxy groups provided moderate to good yields of 90%, 91%, and 81%, respectively. Moreover,
the chiral cis-3-hydroxyazetidin-2-ones underwent acetylation, and their enantiomeric excess was
assessed using the 1H NMR technique, employing chiral shift reagents. To gain insights into the
active sites of the biocatalyst, molecular docking studies of compounds 5(a-i) with pancreatic lipase
(PDB ID: 1LBS) were carried out. Additionally, the proposed interaction of substituents with the
biocatalyst established the absolute stereochemistry of the target chiral cis-3-hydroxyazetidin-2-ones
using Seebach's model in comparison to Jone's models.
Pyridazine (1, 2-diazine): A Versatile Pharmacophore Known for its Utility
in Biological Systems
Authors: Sharma Swati 
Published: January 2024

:
The present review describes the biological essence of pyridazine scaffold. Around
142 biologically potential pyridazine entities are gathered in a pile from documented literature.
Some of them are commercially available drugs, few are naturally occurring pyridazine compounds,
and a wide variety of compounds containing pyridazine moiety are biologically tested,
and some are under clinical trials. Rather than collecting large quantities of data, an attempt is
made to compile valuable entities. However, efforts have been made to compile the maximum
literature in brief. The main motto of this review is to provide a combination of therapeutically
active pyridazine containing compounds for further drug design, discovery, and development to
contribute to future medicinal chemistry. Our approach is to bring the most biologically potent
pyridazine derivatives to medicinal chemists, biologists, pharmacists, and organic chemists. The
present work encompasses the literature from 2000-2022 from different and authentic sources.
The work is divided according to the bioactive nature of pyridazine nucleus.
An Efficient Aspect-based Sentiment Classification with Hybrid Word
Embeddings and CNN Framework
Authors: Agrawal Monika , Moparthi Nageswara Rao 
Published: January 2024

Background:
As the e-commerce product reviews and social media posts are increasing
enormously, the size of the database for polarity/ sentiment detection is a challenging task, and
again, predicting polarities associated with respect to aspect terms end to end in a sentence is a havoc
in real-time applications. Human behavior is influenced by the various opinions generated in society.
Public opinion influences our decisions most often. Businesses and establishments always
need to collect the opinion of the society, which they try to obtain using customer feedback forms
and questionnaires or surveys, which help them to be aware of the shortcomings if any, and to use
suggestions to improve quality. It works in the same way for customers as well and the opinions of
other customers about a particular product can come in handy when deciding to buy a product.

Objectives:
In this work, an efficient Aspect-based Sentiment Classification technique has been introduced
with a hybrid, multiple-word embedding methods and implemented using the CNN
framework on large databases.

Methods:
Most of the traditional models have a limitation on the dependency for one or more similar
types of aspect words for sentiment classification problem. However, these conventional models
such as TF-ID, Word 2Vec and Glove method consumes much more time for word embedding process
and Aspect terms generation and further process of aspect level sentiment classification. Further,
these models are facing problems of high true negative rate and misclassification rate on large
aspect databases in sentiment classification. In this article, we have introduced an efficient Proposed
ensemble word embedding model in the CNN network and defined Hybrid Word2 Vec method, Hybrid
Glove word embedding method and Hybrid Random Forest model for sentiment classification.

Results:
Experiments on a widely used benchmark prove that the proposed word embedding method-
based classification technique results in to higher true positive rate with minimal misclassifications
and also supports better runtime and accuracy than the traditional word embedding-based aspect
level classification approaches.

Conclusion:
In this article, a hybrid ensemble feature ranking-based classification model is proposed on the large aspect databases. In this work, advanced multiple-word embedding methods are
implemented to improve the essential feature extraction problem in the aspect level sentiment process. These multiple-word embedding methods are applied to the sentiment databases in the CNN
framework.
The Neuroanatomy, Etiopathogenesis, and Novel Therapeutic Targets in
Depressive Disorders
Authors: Arora Indu , Khurana Kunal , Kumar Manish 
Published: January 2024

Abstract:
Depression has a high prevalence and associated comorbidities. It is still unknown what
the molecular basis of depression is, regardless of many theories that have been put up to explain it.
Many researchers investigate that present-day therapies for depression are ineffective due to their
low efficacy, delayed onset of action (typically two weeks), and adverse effects. Novel medications
that operate more quickly and effectively are thus needed. Several novel molecules (e.g., ketamine,
buprenorphine) have been proven to produce quick and dependable antidepressant benefits in depressive
patients who are resistant to treatment; yet, questions about their effectiveness, possible
abuse, and adverse effects persist. The molecular basis and pharmacological interventions for depression
were included in this study. Even if pharmaceutical treatments for depression have mostly
failed to alleviate the condition, identifying and addressing possible risk factors in an effort to reduce
the prevalence of this psychiatric disease is beneficial for public health. We emphasized the
neuroanatomy and etiopathogenesis of depression, along with a discussion of the putative pharmacological
mechanisms, novel targets, research hurdles, and prospective therapeutic futures.
Distribution of hepatitis С virus drug resistance mutations among patients with recurrence of the disease during therapy with direct antiviral drugs
Authors: Reingardt D. E. , Ostankova Yu. V. , Lyalina L. V. , Anufrieva E. V. , Semenov A. V. , Totolian Areg A. 
Published: January 2024

The aim of the study was to identify the prevalence of drug resistance mutations in the hepatitis C virus among patients with relapse of the disease on therapy with direct antiviral drugs.Materials and methods. The study material included 31 blood plasma samples from patients with chronic hepatitis C with relapse of the disease on therapy with direct antiviral drugs. Samples were screened for the presence of HCV RNA. In case of detection of HCV RNA, amplification was carried out using a set of primers jointly flanking the NS3, NS5A, NS5B genes. After sequencing the nucleotide sequences of these genes, the subtype of the virus was determined and drug resistance mutations were identified.Results and discussion. The age of the patients ranged from 33 to 62 and averaged 45.8±8.38 years. The number of men in the group prevailed compared to women — 21 (67%) and 10 (33%), respectively. Viral load determination results ranged from 3.1×103 to 4.2×107 IU/ml. The distribution of genotypes was as follows: 1a — 26% (n=8), 1b — 29% (n=9), 3a — 45% (n=14). The nucleotide sequence of the NS3, NS5A, NS5B regions was determined in all samples. Mutations associated with drug resistance were detected in 87% (n=27). In all identified cases, the mutations resulted in viral resistance to at least one drug included in the patient’s current treatment regimen. In one patient, amino acid substitutions were found in three regions at once, which led to the emergence of resistance to two drugs in the regimen.Conclusion. Conducting a preliminary examination of patients to identify mutations of drug resistance to direct antiviral drugs can affect the effectiveness of the planned treatment and the choice of the optimal regimen.
“Das ist nicht die Psychoanalyse”. Algunas reflexiones sobre las definiciones freudianas del psicoanálisis: teoría, práctica y política
Authors: Scholten Hernán 
Published: January 2024

La pregunta que propone este dossier -¿Qué es el psicoanálisis?- ha sido formulada en múltiples ocasiones desde hace décadas, pero quizá en pocas ocasiones ha sido debidamente problematizada. A esto se suma esa particular expresión que es muy común escuchar en el ámbito psicoanalítico, utilizada a modo de conjuro de ostracismo: “¡Eso no es psicoanálisis!”.
Frente a este panorama, ante este aparente escaso interés actual por la definición, en simultáneo con cierto apremio por señalar aquello que queda por fuera del psicoanálisis, este breve artículo propone analizar un conjunto de textos en los que Freud busca delimitar no sólo qué es el psicoanálisis sino también los mecanismos implicados y los lugares autorizados para señalar las desviaciones respecto de la disciplina freudiana. En otras palabras, se busca mostrar que el psicoanálisis, lejos de reducirse a una metodología de investigación, una modalidad de tratamiento de la neurosis o una teoría, se define también como movimiento. Y la cuestión del “movimiento ψ” llevará a reflexionar respecto de sus mecanismos de (re)producción y algunas de sus consecuencias históricas.
A la luz de este recorrido, se busca mostrar que esta pregunta, que en principio puede parecer meramente técnica y “científica”, remite necesariamente a lo político.
Do Eastern Religious Traditions Stifle or Encourage Corporate Innovation? Evidence from China
Authors: Liang Lihong , Liu Siyi , Yang Daoguang , Zhang Chunqiu 
Published: January 2024

ABSTRACT
Although the relationship between Western religiosity and innovation is widely investigated, the effect of Eastern religious traditions on corporate innovation remains unexplored. Using a sample of firms listed in Chinese A-share stock exchanges, we find that firms registered in areas with stronger Eastern religious traditions (Buddhism and Taoism) are generally more innovative than firms registered in areas with weaker Eastern religious traditions. This result suggests that Eastern religiosity promotes rather than stifles corporate innovation. We find additional evidence suggesting that Eastern religiosity promotes corporate innovation mainly through the following three channels: (1) fostering nonexclusivity and openness to science and innovation, (2) mitigating agency conflicts, and (3) nurturing commitment and fortitude.
JEL Classifications: N35; D81; O31.
Clinical Prediction Models Combining Routine Clinical Measures Have High Accuracy in Identifying Youth-Onset Type 2 Diabetes Defined by Maintained Endogenous Insulin Secretion: The SEARCH for Diabetes in Youth Study
Authors: Jones Angus G. , Shields Beverley M. , Oram Richard A. , Dabelea Dana M. , Hagopian William A. , Sharp Seth A. , Lustigova Eva , Shah Amy S. , Knupp Julieanne , Mottl Amy K. , D’Agostino Ralph B. , Williams Adrienne , Marcovina Santica M. , Pihoker Catherine , Divers Jasmin , Redondo Maria J. 
Published: January 2024

OBJECTIVE
With high prevalence of obesity and overlapping features between diabetes subtypes, accurately classifying youth-onset diabetes can be challenging. We aimed to develop prediction models that, using characteristics available at diabetes diagnosis, can identify youth who will retain endogenous insulin secretion at levels consistent with type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
We studied 2,966 youth with diabetes in the prospective SEARCH for Diabetes in Youth study (diagnosis age ≤19 years) to develop prediction models to identify participants with fasting C-peptide ≥250 pmol/L (≥0.75 ng/mL) after &gt;3 years’ (median 74 months) diabetes duration. Models included clinical measures at the baseline visit, at a mean diabetes duration of 11 months (age, BMI, sex, waist circumference, HDL cholesterol), with and without islet autoantibodies (GADA, IA-2A) and a type 1 diabetes genetic risk score (T1DGRS).

RESULTS
Models using routine clinical measures with or without autoantibodies and T1DGRS were highly accurate in identifying participants with C-peptide ≥0.75 ng/mL (17% of participants; 2.3% and 53% of those with and without positive autoantibodies) (area under the receiver operating characteristic curve [AUCROC] 0.95–0.98). In internal validation, optimism was very low, with excellent calibration (slope 0.995–0.999). Models retained high performance for predicting retained C-peptide in older youth with obesity (AUCROC 0.88–0.96) and in subgroups defined by self-reported race and ethnicity (AUCROC 0.88–0.97), autoantibody status (AUCROC 0.87–0.96), and clinically diagnosed diabetes types (AUCROC 0.81–0.92).

CONCLUSIONS
Prediction models combining routine clinical measures at diabetes diagnosis, with or without islet autoantibodies or T1DGRS, can accurately identify youth with diabetes who maintain endogenous insulin secretion in the range associated with T2D.
Pendidikan Lingkungan melalui Virtual Marine Edutourism bagi Siswa Sanggar Belajar Sungai Penchala, Malaysia
Authors: Hayati Riza Sativani , Jariah Ainun , Imam Yatin Khoirul , Yoluut Megi Adrianto , Kusmawan Indra 
Published: January 2024

Literasi lingkungan menjadi bagian penting multiliterasi yang harus dimiliki oleh siswa di Era Revolusi Industri 5.0. Salah satu yang dapat diupayakan untuk meningkatkan literasi lingkungan adalah pendidikan lingkungan. Siswa Sanggar Belajar Sungai Penchala merupakan Warga Negara Indonesia di Malaysia yang berhak menerima pendidikan secara layak, terutama pendidikan lingkungan. Pendidikan lingkungan diberikan kepada mereka melalui implementasi Experiential and Joyful Learning-Marine Edutourism (EJoy-ME) melalui underwater virtual diving menggunakan google street view pada aplikasi google earth. Kegiatan ini mengikuti sintaks EJoy-ME yang sebelumnya telah terbukti meningkatkan literasi lingkungan, yaitu: leisure, experiencing, reflecting, processing, generalizing, dan testing in new situation. Pengabdian masyarakat berupa EJoy-ME melalui underwater virtual diving ini efektif sebagai alternatif pendidikan lingkungan yang dibuktikan dengan kenaikan literasi lingkungan aspek pengetahuan. Kegiatan pembelajaran ini diharapkan dapat terus dilakukan agar menjadi bagian dari solusi permasalahan rendahnya literasi lingkungan masyarakat.
Penguatan Nasionalisme Melalui Pembelajaran Pancasila dan Metode Repetisi bagi Siswa di Sanggar Bimbingan Rawang Selangor, Malaysia
Authors: Makmur Sitti Magfirah , Dunggio Rahmat , Pilomonu Moh. Ziad , Maulana Rizki 
Published: January 2024

Sanggar Bimbingan (SB) adalah sekolah alternatif utama bagi anak-anak Pekerja Migran Indonesia (PMI) di Malaysia. Bukan hanya lemah dalam hal statusnya sebagai lembaga pendidikan non-formal, dalam hal fasilitas dan sumber daya tenaga pendidik masih banyak SB masih tergolong sangat rendah. Salah satu SB yang kondisinya cukup memprihatinkan adalah SB Rawang. Kondisi yang serba kekurangan di SB Rawang ini menyebabkan suntikan motivasi menjadi hal yang sangat dibutuhkan. Motivasi ini bukan saja hanya untuk para siswanya, melainkan juga penting untuk guru atau pembimbingnya. Selain masalah motivasi, tingkat pengajaran dan penanaman nasionalisme juga menjadi hal yang sangat urgen untuk menjadi perhatian. Maka dari itu Pengabdian di SB Rawang melalui PkM-KI Angkatan ke-6 ini difokuskan pada program motivasi bagi siswa dan guru pembimbingnya serta penguatan nasionalisme khususnya pengenalan Pancasila sebagai Dasar Negara. Metode yang digunakan adalah Metode Repetisi. Sedangkan untuk penguatan motivasi bagi siswa dan guru pembimbing dengan cara memanfaatkan fasilitas multimedia yang tersedia. Hasil dari program ini memberikan dampak yang sangat signifikan. Dalam 3 hari pelaksanaan program, suasana pembelajaran di SB Rawang menjadi sangat ceria dan penuh semangat. Para siswa juga telah dapat menghafal dengan lancar serta memberikan contoh sederhana mengenai nilai-nilai Pancasila.
Factors Affecting Economic Growth in West Sumatera Province Using Panel Data Regression Analysis
Authors: Sherly Helma Putri  , Helma  
Published: January 2024

Economic development is considered successful if the economic growth rate of its people reaches a high level. Indonesia has positive economic growth with economic growth rates above 5% in each quarter. However, the high economic growth of Indonesia does not mean that all regions have the same growth rate. Where the increase in the number of goods and services received or the added value of production factors is often referred to as economic growth. Regional economic growth in West Sumatera Province is known to tend to be negative. This study aims to obtain an overview of panel data regression models and factors that have an influence on economic growth in West Sumatera Province for the period 2018 to 2022. The best regression model obtained is the fixed effect model (FEM), where at a significant level of 5%, the factors that have an influence and positive relationship on economic growth are the human development index and government spending.
La traducción de las Odas de Anacreonte y de Museo de Graciliano Afonso: concepto y métodos
Authors: Salas Salgado Francisco 
Published: January 2024

El prolífico literato y humanista canario Graciliano Afonso Naranjo publicó en Puerto Rico, en el año 1838, una traducción cuyo título es Odas de Anacreon. Los Amores de Leandro y Hero, la cual apareció junto a una obra de creación El beso de Abibina. El texto de esta edición puertorriqueña, lleno de erratas, fue posteriormente transcrito en un volumen manuscrito que conserva la obra de este traductor y que se encuentra en los fondos de «El Museo Canario» de Las Palmas de Gran Canaria. El presente artículo trata de analizar los aspectos teóricos que aparecen de forma clara o latente en todas las partes que guardan relación con la traducción, en un intento de conocer y sistematizar los principios que guían a este traductor y su vinculación con el contexto en que se encuadran.