bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subjective assessment of occupational stress and mental health of nurses during the Covid-19 pandemic period
Authors: Kowalczuk Krystyna , Tomaszewska Katarzyna , Chilińska Joanna , Krajewska-Kułak Elżbieta , Sobolewski Marek , Hermanowicz Justyna M. 
Published: November 2023

IntroductionHealth status, sickness absence, and nurses’ attrition have a direct impact on the quality of care provided and patients’ health outcomes. The Covid-19 pandemic exacerbated issues that existed within the Polish healthcare system prior to the pandemic, including staff shortages, low wages, and system inadequacies. The aim of this study was to investigate how nurses during the Covid-19 pandemic period rated the burdensomeness of job characteristics and their mental health status, as well as the correlations between factors directly caused by the Covid-19 pandemic and nurses’ subjective assessments of job characteristics and mental health.MethodThe cross-sectional study was conducted in January 2022, in Poland and involved 796 registered nurses working in hospitals.ResultsDespite the pandemic’s sweeping societal effects, this research finds limited alteration in nurses’ perceptions of job stress and self-assessed mental health. Factors such as contact with infected patients, quarantine, and isolation do not appear to substantially modify mental health perceptions among nurses. Intriguingly, nurses subjected to COVID-19 testing report heightened stress and compromised mental health.ConclusionThe interplay of diverse factors influencing the well-being of nurses is intricately complex. It is advisable to prudently execute interventions and strategies to address the pandemic, aiming to alleviate its potential adverse effects on the mental health of nurses.
How to deal with sickness absence among primary school pupils? Adaptation of the “Medical Advice for Sick-reported Students” intervention
Authors: Pijl Esther K. , Vanneste Yvonne T. M. , Mathijssen Jolanda J. P. , Feron Frans J. M. , de Rijk Angelique E. 
Published: November 2023

BackgroundMissing school impacts both education and health. The purpose of this study was to address sickness absence in primary schools by adjusting the ‘Medical Advice for Sick-reported Students’ intervention for secondary schools. This was necessary because of fundamental differences in relation to the children’s age and in the schools’ organizational structure.MethodsThe intervention mapping approach steps 1 through 4 were used to adapt ‘Medical Advice for Sick-reported Students’ to primary schools (MASS-PS), including a literature search, stakeholder interviews, establishing a planning group and pre-testing.ResultsIn step 1, a planning group was formed and a logic model of the problem was created. In step 2, a logic model of change was created. In step 3, a theoretical basis and practical strategies were determined. In step 4, practical support materials were designed, and two pre-tests of the materials were performed.ConclusionIntervention mapping was successfully used to adapt MASS to primary schools. The main changes were the lowering of the threshold for extensive sickness absence, consultations between teacher and attendance coordinator, and addition of two experts. With MASS-PS, sickness absence can be addressed as a “red flag” for underlying problems.
Responsibility of education in improving medical college students’ ability to prevent and respond to public health emergencies in China – A systematic review
Authors: Fang Xin , Zhao Lei , Pang Ran , Li Huarong , Ye Pian 
Published: November 2023

BackgroundThe outbreak of coronavirus disease 2019 (COVID-19) has highlighted the critical importance of sufficient preparedness for public health emergencies. This places higher requirements on the ability of medical staff to deal with such emergencies. Nonetheless, education courses on public health emergencies in China are usually aimed at public health students, and not at all medical college students. Importantly, these medical students will become medical workers who are generally the first-contact personnel and play an irreplaceable role in responding to most public health emergencies. Therefore, it is urgent to strengthen educational courses to enable these students to adequately prevent and respond to public health emergencies.ObjectivesThe purpose of this systematic review was to reveal the current unsatisfactory status of Chinese medical college students’ knowledge and skills in dealing with public health emergencies and their training needs.MethodsWe searched EMBASE, PubMed, Google Scholar, Web of Science, CNKI, Wan Fang, and VIP Information Network for all associated original studies written in English and Chinese from the inception of these databases until March 12, 2022.ResultsThis systematic review screened out 15 eligible studies that met the inclusion criteria. These studies demonstrated that Chinese medical college students generally have a low ability to deal with public health emergencies. Most students believe it is essential to master coping with public health emergencies and desire to acquire this knowledge. But the participation rate is low, and only a few students actively seek relevant knowledge.ConclusionThe findings of this review illustrate the importance of improving medical college students’ education to prevent and deal with public health emergencies. It is necessary to improve medical college students’ education in responding to public health emergencies.Systematic Review Registration: PROSPERO, Identifier [CRD42023467374].
Family caregiver’s willingness to care from the perspective of altruism
Authors: Li Jun , Zhan Jing-Chun , Xie Cui-Hua , Han Shao-Yong 
Published: November 2023

ObjectivesThe willingness of family members to take care of older relatives directly affects the quality of life of disabled older adults, so it is necessary to understand the status quo of willingness to care and its influencing factors. This has been extensively studied in other countries, but, it is rarely studied in China. Based on the theory of altruism, employing a unique sample from Shanghai, China in 2017 and 2022, we attempt to reveal the influencing factors of the care willingness of family caregivers during the transition period.MethodsTo measure caregiver burden and functional disability of the care recipient, we employ the Zarit Burden Interview (ZBI) and the Barthel Index, respectively. Then we utilized the ordinary least squares (OLS) methodology and estimated four regression models. Models 1, 2, and 3 examined the impact of the variables of the caregiver burden, responsibility and love, and the quality of the caregiver-caregiver recipient relationship, respectively, on family caregivers’ willingness to care. Model 4 was the full model. To testify whether the caregiver burden is likely to act as a mediator, path analysis was used, and the path was adjusted and verified.ResultsAccording to the survey, in Shanghai, only half of the caregivers had a very high care willingness to care for disabled older relatives, while nearly one-tenth of the caregivers had a low willingness. It was the caregiver burden rather than the functional disability of older adults that harms family caregivers’ willingness to care. Responsibility and caring out of love were positively related to care willingness. Relationship quality was the most important influencing factor, explaining 10.2% of the variance in care willingness. Path analysis demonstrated that responsibility, caring out of love, and relationship quality directly and through the mediation of caregiver burden indirectly affected care willingness.ConclusionOur results revealed that reciprocal altruism presented by the quality of the caregiver-care recipient relationship had a significantly positive impact on family caregivers’ willingness to care. In addition, the caregiver burden was found not only directly affected care willingness, but also acted as a mediator. To promote the perfection of laws and policies, comprehensive samples of different types of cities should be included and the measurement of key variables could be further improved in future studies.
Stakeholders' views and opinions on existing guidelines on “How to Choose Mental Health Apps”
Authors: Khan Wishah , Jebanesan Bertina , Ahmed Sarah , Trimmer Chris , Agic Branka , Safa Farhana , Ashraf Aamna , Tuck Andrew , Kavic Kelsey , Wadhawan Sapna , Abbott Maureen , Husain Omair , Husain Ishrat , Akhter Hamid Muhammad , McKenzie Kwame , Quintana Yuri , Naeem Farooq 
Published: November 2023

BackgroundMental health Applications (Mhealth Apps) can change how healthcare is delivered. However, very little is known about the efficacy of Mhealth Apps. Currently, only minimum guidance is available in Assessment and Evaluation Tools (AETs). Therefore, this project aims to understand AET developers' perspectives and end users' experiences and opinions on “how to choose a Mhealth App”.ObjectiveThe primary objectives were: (1) obtaining stakeholder's opinions and experiences of development and use of AETs for Mhealth Apps, their weaknesses and strengths, and barriers in their implementation of Mhealth Apps; (2) the experiences of App users, their analyzation and, obstacles in the use of apps; and (3) to quantify themes related to choosing a Mhealth App.MethodsThis qualitative study, used a sampling method to recruit six stakeholders (one App developer, two AET developers, an individual with lived experience of mental health illness, and two physicians) who were interviewed using a topic guide. These were examined by researchers (CT, WK, &amp; FN) using thematic content analysis. Additionally, an anonymous online survey of 107 individuals was conducted.FindingsOur analyses revealed six main themes: (a) needs and opportunities; (b) views on Mhealth apps; (c) views &amp; opinions on AETs; (d) implementation barriers; (e) system of evaluation and; (f) future directions. The first key concept was, all stakeholders agreed that Apps could significantly impact mental health and that end-users were unaware of mental health AETs and Apps. Secondly, due to commercial interests, end-users reliability of App evaluations requires clear conflict-free guidelines. Thirdly, AETs should be evaluated and developed through a rigorous methodology. Finally, stakeholders shared insights into future developments for AETs and Mhealth Apps. Additionally, online survey respondents chose a “health professional” as their preferred source of guidance in selecting a Mhealth app (84%) and best suited to develop guidelines (70%).ConclusionThe interviews and survey highlight the need for Mhealth Apps to be regulated and the importance of health professionals' engagement in the implementation process. Similarly, without well-defined roles for App evaluations within the health care system, it is unlikely that AETs will have wider spread use and impact without risk.
Barriers and enablers to the implementation of one health strategies in developing countries: a systematic review
Authors: Yopa Daniele Sandra , Massom Douglas Mbang , Kiki Gbètogo Maxime , Sophie Ramde Wendkoaghenda , Fasine Sylvie , Thiam Oumou , Zinaba Lassane , Ngangue Patrice 
Published: November 2023

IntroductionOne Health is a concept that establishes the link between humans, animals and the environment in a collaborative approach. Since One Health’s inception, several interventions have been developed in many regions and countries worldwide to tackle complex health problems, including epidemics and pandemics. In the developed world, many collaborative platforms have been created with an international strategy to address issues specific or not to their environment. Unfortunately, there is a lack of synthesis on the challenges and opportunities Low and Middle-Income Countries (LMICs) face.MethodsFollowing The Preferred Reporting Elements for PRISMA Systematic Reviews and Meta-Analyses (PRISMA), we conducted a systematic review. We applied a search strategy to electronic bibliographic databases (PubMed, Embase, Global Health, Web of Science and CINAHL). We assessed the included articles’ quality using the Mixed Methods Appraisal tool (MMAT).Results and discussionA total of 424 articles were initially identified through the electronic database search. After removing duplicates (n = 68), 356 articles were screened for title and abstract, and 16 were retained for full-text screening. The identified barriers were the lack of political will, weak governance and lack of human, financial and logistics resources. Concerning the enablers, we listed the existence of a reference framework document for One Health activities, good coordination between the different sectors at the various levels, the importance of joint and multisectoral meetings that advocated the One Health approach and the Availability of funds and adequate resources coupled with the support of Technical and Financial partners.ConclusionOne Health strategy and interventions must be implemented widely to address the rising burden of emerging infectious diseases, zoonotic diseases, and antimicrobial resistance. Addressing those challenges and reinforcing the enablers to promote managing global health challenges is necessary.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/record_email.php, Unique Identifier: CRD42023393693.
Critical factors influencing visitor emotions: analysis of “restorativeness” in urban park visits in Fuzhou, China
Authors: Wu Yu , Liu Jian , Quevedo Jay Mar D. , Cheng Huishan , Yu Kunyong , Kohsaka Ryo 
Published: November 2023

ObjectiveTo date, a comprehensive analysis of urban green space (UGS) visitors’ emotional remains largely unexplored. In this study, we focus on how UGS environmental preferences, restorativeness, other physical factors (sound, air, and thermal environments), and individual characteristics affecting visitor emotions. Such a comprehensive analysis would allow relevant practitioners to check the environmental quality of UGSs and improve certain conditions to promote visitor emotions.MethodsA total of 904 questionnaire responses with concurrently monitored physical factors were analyzed by independent sample t-tests, one-way ANOVA and path analysis.ResultsThe thermal evaluation had the largest impact on positive emotions (β = 0.474), followed by perceived restorativeness (β = 0.297), which had β values of −0.120 and −0.158, respectively, on negative emotions. Air evaluation was more effective for increasing positive emotions (β = 0.293) than reducing negative emotions (β = −0.115). Sound evaluation also had similar results (β = 0.330 vs. β = −0.080). Environmental preference significantly influenced only positive emotions (β = 0.181) but could still indirectly impact negative emotions. Moreover, objective physical factors can indirectly affect visitors’ emotions by enhancing their evaluations..ConclusionThe influence of different UGS environmental factors on visitors’ emotions vary, as does their impacts on positive versus negative emotions. Positive emotions were generally more affected than negative emotions by UGS. Visitor emotions were mainly influenced by physical and psychological factors. Corresponding suggestions are proposed for UGS design and management in this study.
Trends and prescribing patterns of oral anti-neoplastic drugs: a retrospective longitudinal study
Authors: Lv Xiaoqun , Ren Weifang , Ran Shan , Zhao Yuhan , Zhang Jihong , Chen Jun , Zhang Ning 
Published: November 2023

BackgroundCancer as a global public health problem, imposes a heavy disease burden. With the rapid development of oral anti-neoplastic drugs, there has been a paradigm shift in the treatment of cancer from intravenous to oral administration.ObjectiveThis study was conducted to investigate the trends and prescribing patterns of oral anti-neoplastic drugs in an academic tertiary hospital in China.MethodsA single-center and retrospective analysis was performed based on the prescriptions of outpatients treated with oral anti-neoplastic drugs from 2017 to 2022. Yearly prescriptions and expenditure were calculated according to their pharmacological classes, and trends were further analyzed. Defined daily doses (DDDs) and defined daily cost (DDC) of oral targeted anti-neoplastic drugs were also determined.ResultsBoth the number of prescriptions and expenditure of oral anti-neoplastic drugs increased progressively. There was a significant upward trend in the number and proportion of prescriptions for the older adult group, male group, and patients with gynecologic/genitourinary and respiratory cancer. Hormonal therapy agents accounted for the highest proportion of prescriptions, and letrozole was initially the most frequently prescribed drug. The number of DDDs of total oral targeted anti-neoplastic drugs showed a continuously ascending trend, primarily driven by the usage of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and BCR-ABL TKIs.ConclusionThe prescriptions and expenditure of oral anti-neoplastic drugs, and the number of DDDs of oral targeted anti-neoplastic drugs all showed a progressively ascending trend. Further studies are needed to evaluate the long-term health and financial outcomes, and the factors influencing these prescribing patterns.
Mechanisms connecting square dance to sleep quality among middle-aged and older Chinese females: serial mediation roles of social support and depressive symptoms
Authors: Wu Jun , Yu Yong , Qin Keke , Ou Zhiwen 
Published: November 2023

BackgroundSquare dance is gaining increasing popularity among middle-aged and older Chinese women who are also at high risk of sleep disturbance. Although previous studies have shown exercise could improve sleep quality, the association between square dance and sleep quality remains to be discussed, and even less is known about the potential mechanism underlying this association.PurposeThis study aims to investigate the relationship between square dance and sleep quality and test if social support and depressive symptoms together play a serial mediating role in the influence of square dance on sleep quality.MethodsA cross-sectional study was conducted among 549 middle-aged and older Chinese females from September to December 2020 in Shao Yang City, Hunan Province of China, with ethics approval granted (SYU [2020]002). Square dance involvement was assessed by three questions about the time participants spent in square dance. Social support, depressive symptoms, and sleep quality were measured using the Pittsburgh Sleep Quality Index (PSQI), Social Support Self-Rating Scale (SSRS), and 9-item Patient Health Questionnaire (PHQ-9), respectively. The serial mediation model was analyzed by the bootstrapping method to assess whether social support and depressive symptoms mediate the relationship between square dance and sleep quality.ResultsTwo-thirds of the participants had high involvement in square dance and most reported a moderate and high level of social support (98.54%). The prevalence of depressive symptoms and sleep disturbance was 19.49 and 26.78%, respectively. The serial mediation model showed a significant association between square dance and sleep quality, which was fully mediated by social support and depressive symptoms in a serial model (total effect c = −0.114, 95%CI = −0.227 to −0.001; direct effect c’ = −0.036, 95% CI = −0.138 to 0.065; total indirect effect ab = −0.077, 95% CI = -0.139 to-0.016).ConclusionOur study extends the understanding of how square dance is associated with sleep quality through the serial mediating roles of social support and depressive symptoms. It provides crucial implications for developing square dance interventions to improve sleep quality among middle-aged and older Chinese females.
The unique challenges of AYA cancer care in resource-limited settings
Authors: Hovsepyan Shushan , Hoveyan Julieta , Sargsyan Lilit , Hakobyan Lusine , Krmoyan Lusine , Kamalyan Alisa , Manukyan Narek , Atoyan Stepan , Muradyan Armen , Danelyan Samvel , Tamamyan Gevorg , Bardakhchyan Samvel , Papyan Ruzanna 
Published: November 2023

IntroductionAdolescents and young adults (AYAs) diagnosed with cancer represent a distinct group with exceptional and unique characteristics. The survival rates for this age group are worse than in children or adults. Cancer care for this population is a challenge, not only for low-income countries but also for the developed world. This review addresses the unique challenges adolescents and young adults (AYAs) diagnosed with cancer in low-income countries face.MethodsTwo individual authors conducted the literature review to present the global burden of AYAs in resource-limited settings. The articles selected focused on AYA care from Latin America, Asia, and Africa.ResultsAmong the challenges of managing AYAs with cancer are the absence of national and/or hospital cancer registries, and a lack of adequate infrastructure, AYA-dedicated programs, appropriate psycho-social support, fertility preservation, and genetic counseling services. Furthermore, education and training activities specifically dedicated to the care of AYAs diagnosed with cancer are scarce in those countries.ConclusionImplementing a dedicated AYA program in resource-limited settings will be critical in providing patient-centered care bolstered by age-appropriate infrastructure and comprehensive clinical, psycho-social, and allied health support. It will significantly reduce the treatment abandonment rate, diminish the duration of diagnosis delay, and alleviate emotional detachment and disarray.
Elevated gonadotropin levels are associated with increased biomarker risk of Alzheimer's disease in midlife women
Authors: Nerattini Matilde , Rubino Federica , Jett Steven , Andy Caroline , Boneu Camila , Zarate Camila , Carlton Caroline , Loeb-Zeitlin Susan , Havryliuk Yelena , Pahlajani Silky , Williams Schantel , Berti Valentina , Christos Paul , Fink Matthew , Dyke Jonathan P. , Brinton Roberta Diaz , Mosconi Lisa 
Published: November 2023

IntroductionIn preclinical studies, menopausal elevations in pituitary gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), trigger Alzheimer's disease (AD) pathology and synaptic loss in female animals. Herein, we took a translational approach to test whether gonadotropin elevations are linked to AD pathophysiology in women.MethodsWe examined 191 women ages 40–65 years, carrying risk factors for late-onset AD, including 45 premenopausal, 67 perimenopausal, and 79 postmenopausal participants with clinical, laboratory, cognitive exams, and volumetric MRI scans. Half of the cohort completed 11C-Pittsburgh Compound B (PiB) amyloid-β (Aβ) PET scans. Associations between serum FSH, LH and biomarkers were examined using voxel-based analysis, overall and stratified by menopause status. Associations with region-of-interest (ROI) hippocampal volume, plasma estradiol levels, APOE-4 status, and cognition were assessed in sensitivity analyses.ResultsFSH levels were positively associated with Aβ load in frontal cortex (multivariable adjusted P ≤ 0.05, corrected for family wise type error, FWE), an effect that was driven by the postmenopausal group (multivariable adjusted PFWE ≤ 0.044). LH levels were also associated with Aβ load in frontal cortex, which did not survive multivariable adjustment. FSH and LH were negatively associated with gray matter volume (GMV) in frontal cortex, overall and in each menopausal group (multivariable adjusted PFWE ≤ 0.040), and FSH was marginally associated with ROI hippocampal volume (multivariable adjusted P = 0.058). Associations were independent of age, clinical confounders, menopause type, hormone therapy status, history of depression, APOE-4 status, and regional effects of estradiol. There were no significant associations with cognitive scores.DiscussionIncreasing serum gonadotropin levels, especially FSH, are associated with higher Aβ load and lower GMV in some AD-vulnerable regions of midlife women at risk for AD. These findings are consistent with preclinical work and provide exploratory hormonal targets for precision medicine strategies for AD risk reduction.