bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probiotic complex supplementation to growing pig’s diet enhances daily growth and reduces fecal gas emission
Authors: Cao Shanchuan , Cho Sungbo , Park Jae Hong , Kim Yangseon , Kim In Ho 
Published: November 2023

A total of 180 growing pigs (Duroc × Landrace × Yorkshire) with an initial body weight (BW) of 23.58 ± 0.8 kg were used in this experiment. According to initial BW and sex, pigs were randomly allotted three dietary treatments, 12 replicates (pen) per treatment, and five pigs per pen. The three dietary treatments were basal diet (CON) and basal diet supplemented with either 0.1% Bacillus and Saccharomyce s spp.-based probiotics complex (BS1) or 0.2% probiotics complex (BS2). The whole experiment lasted 42 days. The results showed that the BW of pigs fed the BS1 diet was significantly higher than those fed the CON diet on day 42 ( P < 0.05). The average daily gain (ADG) of pigs receiving BS1 and BS2 diets was higher than those fed CON diet during days 21–42, whereas during the overall experiment period ADG ( P < 0.05) was higher in only BS1 compared with CON group. The NH3 and H2S emissions on day 42 were reduced from the feces of pigs fed probiotic complex-supplemented diets. Therefore, adding 0.1% probiotic complex to the late-phase diet of growing pigs can more effectively improve BW and daily gain and reduce harmful gas emissions.
The production of charm pentaquark from B meson within SU(3) analysis
Authors: Li Na , Xing Ye , Hu Xiao-hui 
Published: November 2023

AbstractWe study the masses and production modes of pentaquark with the quark constituent $$c\bar{q}qqq$$

c

q

¯

q
q
q

, by the tridiquark-diquark model and systematical light flavor quark symmetry SU(3) analysis. The mass spectrums show that the S-wave singly charm pentaquark $$c{\bar{n}}nnn,~c{\bar{s}}ssn,~c{\bar{n}}ssn$$

c

n

¯

n
n
n
,

c

s

¯

s
s
n
,

c

n

¯

s
s
n

and $$c{\bar{n}}snn$$

c

n

¯

s
n
n

$$(n=u,d)$$

(
n
=
u
,
d
)

are above their strong decay thresholds, while $$c{\bar{s}} nnn$$

c

s

¯

n
n
n

and $$c\bar{s} snn$$

c

s

¯

s
n
n

with parity $$\frac{1}{2}^-$$

1
2

-

are below their strong decay thresholds, which imply the possibility of stable states. Furthermore, we discuss the production of the concerned 15 states from B meson, the analysis within SU(3) symmetry yields the golden channels of production process, $${\overline{B}}^0_s\rightarrow F_{\bar{s}udd}^{+} {\overline{p}},\ B^-\rightarrow F_{\bar{u}dds}^{-} {\overline{\Lambda }}^0$$

B
¯

s
0

→

F

s

¯

u
d
d

+

p
¯

,

B
-

→

F

u

¯

d
d
s

-

Λ
¯

0

, which expected to be work worthily in b-factory.
Determination of the number of shots for Grover’s search algorithm
Authors: Kessler Mathieu , Alonso Diego , Sánchez Pedro 
Published: November 2023

AbstractThis paper focuses on Grover’s quantum search algorithm, which is of paramount importance as a masterpiece of Quantum Computing software. Given the inherent probabilistic nature of quantum computers, quantum programs based on Grover’s algorithm need to be run a number of times in order to generate a histogram of candidate values for solutions, which are then checked to identify the valid ones. In this paper, the distribution of the required number of shots to find all or a fraction of all the solutions to the Grover’s search problem is studied. Firstly, considering the similarity of the probability problem with the well-known coupon collector’s problem, two formulae are obtained from asymptotic results on the distribution of the required number of shots, as the number of problem solutions grows. These expressions allow to compute the number of shots required to ensure that, with probability p, all or a fraction of all the solutions are found. Secondly, the probability mass function of the required number of shots is derived, which serves as a benchmark to assess the validity of the asymptotic approximations derived previously. A comparison between the two approaches is presented and, as a result, a rule of thumb to decide under which circumstances employ one or the other is proposed.
Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2− Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7
Authors: Prat Aleix , Solovieff Nadia , André Fabrice , O'Shaughnessy Joyce , Cameron David A. , Janni Wolfgang , Sonke Gabe S. , Yap Yoon-Sim , Yardley Denise A. , Partridge Ann H. , Thuerigen Astrid , Zarate Juan Pablo , Lteif Agnes , Su Fei , Carey Lisa A. 
Published: November 2023

AbstractPurpose:The MONALEESA-2, -3, -7 trials demonstrated statistically significant and clinically meaningful progression-free survival and overall survival (OS) benefits with ribociclib plus endocrine therapy (ET) versus ET alone in hormone receptor–positive, HER2-negative (HR+/HER2−) advanced breast cancer (ABC). Understanding the association of intrinsic subtypes with survival outcomes could potentially guide treatment decisions. Here, we evaluated the association of intrinsic subtypes with OS in MONALEESA-2, -3, -7.Experimental Design:Tumor samples from MONALEESA-2, -3, -7 underwent PAM50-based subtyping. The relationship between subtypes and OS was assessed using univariable and multivariable Cox proportional hazards models. Multivariable models were adjusted for clinical prognostic factors.Results:Overall, 990 tumors (among 2,066 patients) from ribociclib (n = 580) and placebo (n = 410) arms were profiled. Subtype distribution was luminal A, 54.5%; luminal B, 28.0%; HER2-enriched (HER2E) 14.6%; and basal-like, 2.8%; and was consistent across treatment arms. The luminal A subtype had the best OS outcomes in both arms, while basal-like had the worst. Patients with HER2E (HR, 0.60; P = 0.018), luminal B (HR, 0.69; P = 0.023), and luminal A (HR, 0.75; P = 0.021) subtypes derived OS benefit with ribociclib. Patients with basal-like subtype did not derive benefit from ribociclib (HR, 1.92; P = 0.137); however, patient numbers were small (n = 28).Conclusions:The prognostic value of intrinsic subtypes for OS was confirmed in this pooled analysis of the MONALEESA trials (largest dataset in HR+/HER2− ABC). While basal-like subtype did not benefit, a consistent OS benefit was observed with ribociclib added to ET across luminal and HER2E subtypes.
Methodical Manipulation of the TME in Ovarian Cancer
Authors: Soberanis Pina Pamela , Oza Amit M. 
Published: November 2023

SummaryThe complex interplay between ovarian cancer cells and the tumor microenvironment (TME) modulates progression, with dynamic cellular interactions influenced by external modulators, including neoadjuvant chemotherapy (NACT). A recent article described the alterations within the TME following NACT, either with or without bevacizumab, in ovarian cancer.See related article by Tavira et al., p. 176
Battle Within the Sexes: Differences in Male and Female Immunity and the Impact on Antitumor Responses
Authors: Hunt Katey S. , Alspach Elise 
Published: November 2023

Abstract
The immune system plays critical roles in regulating tumor progression. However, despite established differences in male and female immune cell function, our appreciation of sex as a variable in antitumor immune responses is only beginning to develop. Recent findings in mice have demonstrated for the first time that disparities in cancer incidence between the sexes are driven in part by differences in male and female T-cell responses. This review will discuss the growing body of literature demonstrating that male and female innate and adaptive immune responses against tumors are not equivalent and highlight the impact this may have on tumor responses to immunotherapies.
Performance analysis of voltage source converter based high voltage direct current line under small control perturbations
Authors: Ahmed Mostafa Reem , Emary Salem Adel , Sayed Abdelhamid Ahmed , EL-Shimy Mahmoud Bekhet Mohamed 
Published: November 2023

High voltage direct current (HVDC) systems provide important advantages; among them the ability to transmit enormous amounts of electrical power over great distances at low cost. As a result, planners of power systems consider it as a viable choice for power transmission and interconnection of asynchronous networks. Depending on HVDC grids, continental/super grids have been recently constructed to promote global economic development. The study described in the paper focuses on the behavior of a voltage sourced converter (VSC) based HVDC transmission system comprising three arms-neutral point clamped (NPC) converters interconnecting two asynchronous alternating current (AC)networks. In addition, the system components, and the vector control strategy of active/reactive powers and direct current (DC)bus voltage are simulated in MATLAB/Simulink under varying situations by adjusting the controller’s settings. The study records and analyzes AC/DC voltages and active/reactive powers at two converter stations undervarying power and voltage conditions. The results of the study provide key performance indicators, such as settling time (tsett), steady state error (SSE), overshot/undershoot (OS%/US%), and correlation factor (CF), which demonstrate the robustness of thesystem’s control.
Impact blockchain technology on traditional electronic payment system
Authors: AbdulKarim Talib Ahmed , Hashim Abdulkareem Mustafa , Nasser Selman Saja , AbdulKarim Talib Sally 
Published: November 2023

<span>Every moment there is a new idea and a new project that creates new technologies to make life easier and faster and to invest resources better. In this research, talk about a new technology that is considered a revolution in the age of the Internet, which in turn is the offspring of the new generation of the internet (5G), which is the blockchain technology, which began to be completed and appear to us from 2017, and it is not like other technologies, but in essence depends on changing many of the concepts that we are accustomed to in Communication, exchange and sharing via the Internet, it will change it in the same way as open-source software and in the same way as the Linux system, which, when it appeared, became the main focus for programmers and the development of software technologies, and this is the case with blockchain technology, this technology depends on the user and the customer only. There is no third party or responsible party. The user is responsible here.</span>
The lost jewel of the Atlantic Forest: Kinglet Calyptura Calyptura cristata (Aves: Platyrinchidae) specimen inventory and plumage variation
Authors: Silva e Silva Robson , Pacheco José Fernando , Schweizer Manuel , Kirwan Guy M. 
Published: November 2023

Kinglet Calyptura Calyptura cristata is one of the great enigmas of the South American avifauna. Endemic to an apparently tiny area of south-eastern Brazil, in the Atlantic Forest biome, the species was not definitely seen between sometime in the second third of the 1800s and 1996, when it was briefly rediscovered in submontane forest north-west of Rio de Janeiro. Since then, C. cristata has been reported several times, but without documentation and always by single observers. It is currently considered Critically Endangered by BirdLife International, and various authors have speculated that the species might already be extinct. Given the extreme paucity of knowledge of this species, we provide a complete inventory of museum material for Kinglet Calyptura – more than 100 specimens are listed, the majority held in European collections, almost doubling previous estimates made in the literature. Several are held in relatively small institutions, thereby suggesting that yet more specimens might still be identified or found. In addition, with the benefit of this large sample of material, we discuss morphological variation in the species and we hypothesise particularly about the appearance of male, female and juvenile plumages.
Identity, Belonging and Home
Authors: Dikyurt Ahmet Emre 
Published: November 2023

Abstract
This research paper studies second-generation Bosnians in the United States, to understand the identity formation of this population after the Bosnian War through the lenses of home, belonging and borders. Through archival research and extended interviews, second-generation Bosnian-Americans were asked questions about their dual/hybrid identity and their sense of home and belonging. Analysis of the data shows that the second generation has had relatively weak acculturation, by some measures, due to close identification with their heritage. Yet, the second generation’s view of the Bosnian War is different from that of the first generation, who prefer to distance themselves from memories of war. The second generation would like to preserve their parents’ experiences as a part of their lives and pass it on to the next generation of Bosnian-Americans.
Foster Puppies as Therapeutic Partners: A Model for Mutual Benefit
Authors: Trevathan-Minnis Melissa , Platz Rebecca E. 
Published: November 2023

Abstract
Ample research points to the positive impact of nonhuman animals on humans and the benefits of animal-assisted therapy (AAT) on patients in multiple settings. However, AAT is often a one-sided enterprise, whereby the focus of concern for benefit and growth is centered on the human, and less, or not at all, on the nonhuman animal. We present a model that emphasizes approximate equal benefit for human and nonhuman animals. A treatment approach is described that combines socialization and training of homeless dogs and puppies to increase adoption rates and assess for suitability as therapy or working dogs, with rehabilitating and supporting clients. This model of mutual benefit demonstrates prosocial behavior for clients who participate in the socialization and preparation of homeless puppies for permanent homes in combination with their existing therapeutic goals and is rich territory for symbolic exploration. A case study is presented as an illustration of the model.
Deep Learning Image Segmentation for Atmospheric Rivers
Authors: Galea Daniel , Ma Hsi-Yen , Wu Wen-Ying , Kobayashi Daigo 
Published: November 2023

Abstract
The identification of atmospheric rivers (ARs) is crucial for weather and climate predictions as they are often associated with severe storm systems and extreme precipitation, which can cause large impacts on society. This study presents a deep learning model, termed ARDetect, for image segmentation of ARs using ERA5 data from 1960 to 2020 with labels obtained from the TempestExtremes tracking algorithm. ARDetect is a convolutional neural network (CNN)-based U-Net model, with its structure having been optimized using automatic hyperparameter tuning. Inputs to ARDetect were selected to be the integrated water vapor transport (IVT) and total column water (TCW) fields, as well as the AR mask from TempestExtremes from the previous time step to the one being considered. ARDetect achieved a mean intersection-over-union (mIoU) rate of 89.04% for ARs, indicating its high accuracy in identifying these weather patterns and a superior performance than most deep learning–based models for AR detection. In addition, ARDetect can be executed faster than the TempestExtremes method (seconds vs minutes) for the same period. This provides a significant benefit for online AR detection, especially for high-resolution global models. An ensemble of 10 models, each trained on the same dataset but having different starting weights, was used to further improve on the performance produced by ARDetect, thus demonstrating the importance of model diversity in improving performance. ARDetect provides an effective and fast deep learning–based model for researchers and weather forecasters to better detect and understand ARs, which have significant impacts on weather-related events such as floods and droughts.
Anthropogenic Influence on the Record-Breaking Compound Hot and Dry Event in Summer 2022 in the Yangtze River Basin in China
Authors: Li Wei , Jiang Zhihong , Li Laurent 
Published: November 2023

Abstract
CMIP6 simulations suggest that the probability of the compound hot and dry event occurring in summer 2022 in the Yangtze River basin in China is enhanced by anthropogenic effect by 7 times.
Initial and Transient Growth of Symmetric Instability
Authors: Kimura Satoshi 
Published: November 2023

Abstract
The mechanism of initial and transient perturbations of symmetric instability (SI) in a hydrostatic flow with lateral shear is analyzed by applying the generalized stability analysis. It is well known that the SI’s most rapidly growing motion is along isopycnals, and the growth rates consist of growing, neutral, and decaying modes. The eigenvectors of these three modes are not orthogonal to each other, hence the initial and transient perturbations bear little resemblance to the normal mode. Our findings indicate that the emergence of normal modes occurs within a time span of 1–3 inertial periods, which we refer to as the transient state. The overall growth of perturbation energy is divided into three components: geostrophic shear production (GSP), lateral shear production (LSP), and meridional buoyancy flux (MB). During the transient state, the perturbation energy is partly driven by MB, contrary to the normal mode which has zero MB. The relative energy contribution is evaluated through the ratio to GSP. While the MB-to-GSP ratio of the initial mode is higher than that of the normal mode, the LSP-to-GSP ratio remains constant. In the absence of the fastest-growing normal mode, MB can serve as the predominant initial energy source. The precise transition in the energy regime is contingent upon the geostrophic Richardson number and Rossby number.

Significance Statement
Fronts can be unstable to instabilities, which generate disturbance growth and lead to the mixing of water masses. We wanted to understand the initial and transient development of disturbance growth leading to the well-known exponentially growing state. While the exponentially growing disturbance is dominant in the long run, the disturbance growth may not have enough time to achieve the exponentially growing state. We find that the initial disturbance growth bears little resemblance to the exponentially growing state. Capturing the complete spectrum of front evolution remains challenging, and observations have thus far been limited to short-term records. The insights learned from this study can aid in better characterizing the disturbance growth captured in these short-term records.
The potential for medicinal cannabis to help manage challenging behaviour in people with intellectual disability: A perspective review
Authors: Korb Laura , Tromans Samuel , Perera Bhathika , Khan Nagina , Burrows Lisa , Laugharne Richard , Hassiotis Angela , Allgar Victoria , Efron Daryl , Maidment Ian , Shankar Rohit 
Published: November 2023

Background: Around 2% of the population have intellectual disabilities. Over one-third people with intellectual disabilities (PwID) present with ‘challenging behaviour’, which nosologically and diagnostically is an abstract concept. Challenging behaviour is influenced by a range of bio-psycho-social factors in a population, which is unable to suitably comprehend and/or communicate concerns. This predisposes to poor health and social outcomes. There is no evidence-based treatments for managing challenging behaviour. Cannabidiol (CBD) and tetrahydrocannabinol (THC) are being trialled for a range of disorders, which are over-represented in PwID and provoke challenging behaviours, such as severe epilepsy, spasticity, post-traumatic stress disorder, social phobia, pain, etc. Methods: This perspective review explores the different conditions, which benefit from medicinal CBD/THC preparations, by analysing recent literature from neurobiological, pre-clinical and clinical studies related to the topic. The evidence is synthesised to build an argument of the therapeutic benefits and challenges of medicinal cannabis to manage severe challenging behaviour in PwID. Results: There is developing evidence of medicinal CBD/THC improving psychiatric and behavioural presentations in general. In particular, there is emergent proof in certain key areas of influence of medicinal CBD/THC positively supporting challenging behaviour, for example in children with neurodevelopmental disorders. However, there are significant challenges in employing such treatments in vulnerable populations such as PwID. Conclusion: Further clinical research for the considered use of medicinal CBD/THC for challenging behaviour management in PwID is needed. Strong co-production with experts with lived experience is needed for further testing to be done in this exciting new area.
Engagement in Physical Activity and Quality of Life Among Informal Caregivers of Older Adults
Authors: A’Azman Shamirah , Sung Pildoo , Malhotra Rahul 
Published: November 2023

Objectives This study examined (1) the association of caregiver engagement in physical activity (PA) with their quality of life (QoL) and (2) the moderating effect of caregiver engagement in PA on the relationship between several caregiving stressors and their QoL, among informal caregivers of older adults. Methods Multivariable regression was applied to data from 278 adult caregivers, aged 23–90 years, in Singapore. Results Engagement in PA by caregivers was positively associated with psychological, social relationships, and environment domains of their QoL. Caregiver engagement in PA also mitigated the negative association between care-recipient mood impairment and QoL of caregivers in the physical health and social relationships domains. Discussion QoL of caregivers may be improved or protected by their regular engagement in PA, especially when their care-recipients have mood impairment. Policymakers and practitioners should encourage caregivers to engage in PA and provide them with the necessary support to do so.
Recalcitrant ulcerative genital herpes in an immunocompetent individual treated successfully with imiquimod
Authors: Sachan Suvigya , Potluri Vijay Kiran , Gopinath Hima , Sravanthi Kode Leela , N Prabhakaran , Bharti Jyotsna Naresh , Haritha Thiruveedhula 
Published: November 2023

Background This case report describes the successful use of imiquimod to treat genital herpes in an immunocompetent individual with acyclovir-resistant HSV. Case report A 32 year old male patient, presented with asymptomatic non-healing ulcers over the genital region for 2 years. The ulcers initially responded to acyclovir but became persistent after a few months. He also received multiple courses of antibiotics. On examination, the patient had bilateral inguinal lymphadenopathy and multiple painless ulcers over the coronal sulcus. Routine investigations were normal. The patient was treated with oral and intravenous acyclovir but showed no response. He was then started on topical imiquimod cream applied on alternate days. After one week, the patient presented with pain, redness, burning sensation, and fresh ulcer over the glans which were suspected to be imiquimod-induced irritant reaction or ulcer. Imiquimod was withheld for one week and then restarted at a twice-weekly schedule. After 1 month and 7 days of treatment with imiquimod at a twice-weekly schedule, there was healing of the ulcers. Conclusion This case report illustrates the efficacy of imiquimod cream as a topical treatment for genital herpes simplex in an immunocompetent patient who had previously been unresponsive to treatment with acyclovir.