bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between First Episode Schizophrenia, Metabolic Syndrome and Insulin Resistance-Related Proteins in Female Balb/C Mice
Authors: Sattar Haseeb , Li Huqun , Han Yong , Zhou Hong , Darbalaei Sanaz , Li Weiyong 
Published: December 2023

Background: Metabolic syndrome is a group of different disorders mainly includes, insulin resistance, obesity, cerebrovascular disorders, dyslipidemia, which leads to increase mortality. Patients suffering from related psychotic disorders such as schizophrenia are at the higher risk of developing metabolic syndrome. The aim of this study was to evaluate the association between the first episode of schizophrenia, metabolic syndrome and insulin resistance-related proteins in blood and adipose tissue of mice.
Materials and Methods: Twelve, female Balb/c mice were randomly divided into two groups; one group was injected intraperitoneal MK-801 (0.6mg/kg/d) to induce schizophrenia, and other group received the 0.9% normal saline for two weeks. Body weight, fasting blood glucose (FBG), oral glucose tolerance (OGT), and Homeostatic model assessment (HOMA), were observed. Blood and adipose tissue were collected and Western blotting was done to evaluate the insulin resistance related proteins (GGPPS, FAT, PTP-1B, GRK2, ATGL, FGF21, and PGC-1Î±) by using GAPDH as an internal standard.Â
Results: There was a significant increase in mean body weight in schizophrenic group (21.76 vs 22.81, P=004). On day 14, the FBG, insulin concentrations and Homeostatic model assessment and insulin resistance (HOME-IR) were high in schizhphrenic group vs control group, e.g. 5.3Â±0.6 vs 3.47Â±0.2 (P=0.0001), 28.9Â±2.2 vs 23.3Â±0.6 (P<0.005) and 9.2Â±1.3 vs 3.9Â±0.2 (P=0.0001) . Impaired glucose tolerance deranged from 4.8mmol/L to 6.4mmol/L. Western blotting showed a marked increase in the expression of GGPPS, FAT, ATGL, and FGF21 proteins in monocytes and PTP-1B, GRK2, and PGC-1Î± ratios in adipose tissues.
Conclusion: There was a positive relation between schizophrenia and metabolic syndrome e.g. insulin resistance and obesity. Certain proteins in adipocytes and blood were responsible for causing insulin resistance. [GMJ.2018;7:e692]
Effectiveness of Povidone-Iodine 1% Eye Drop on Streptococcus pneumoniae and Escherichia coli Induced-Keratitis in Mice
Authors: Hadipour Jahromy Mahsa , Najafi Abdolhamid , Majdi Nassab Farzaneh , Moiniyan Mahya 
Published: December 2023

Background: Bacterial keratitis is an ophthalmic infection that may result in irreversible corneal damage. This study aimed to examine the effectiveness of povidone-iodine eye drop 1% in eye infection caused by inoculation of Streptococcus pneumoniae and Escherichia coli of mice.Â Materials and Methods: In this study, 49 adult male CBA/J mice were used that divided into seven equal groups. The corneas of all mice were scratched and infected with a clinical strain of either S. pneumoniae or E. coli topically, except control group. Subgroups received chloramphenicol 0.5% eye drop twice daily in case of S. pneumoniae infection or ciprofloxacin 0.3% eye drop every 4 hours following E. coli infection from or povidone-iodine 1% eye drop in both groups, from post infection (PI) day 3 to7. Slit lamp examinations (SLE) of the corneas and eyes were performed every day to examine detectable or intense corneal opacity and erosion.Â Results: In all infected mice, SLE scores were significantly higher than the control group on PI day 3. Scores increased steadily by time in all infected groups without treatment, reached to maximal value on PI day 7. In infected groups, treatment with either povidone-iodine 1% or chloramphenicol 0.5% or ciprofloxacin 0.3% on day 3, significantly decreased the SLE scores on PI day 7.Â Conclusion: Povidone-Iodine 1% was effective to decrease S. pneumoniae and E. coli induced-keratitis symptoms in mice. Treatment with povidone-iodine 1% was observed time-dependently and was comparable to common eye drop antibiotics. [GMJ.2019;8:e1161]
Gene and Biochemical Pathway Evaluation of Burns Injury via Protein-Protein Interaction Network Analysis
Authors: Rostami-Nejad Mohammad , Rezaei-Tavirani Majid , Mansouri Vahid , Rezaei Tavirani Mostafa , Bashash Davood , Zamanian Azodi Mona 
Published: December 2023

Background: Severe burns injury can affect several vital systems in the body and can cause inflammation in organs such as the heart, liver, and kidney. Many inflammatory mediators and regulatory hormones related to burn injuries are recognized. In this study, the genes related to burn injury interacted via network analysis, and the central nodes were enriched through gene ontology (GO). Materials and Methods: Disease query of STRING database was used for data gathering, and the network was constructed using Cytoscape software version 3.6.0. After gene screening, the central nodes were enriched via GO analysis by ClueGO. The highlighted genes and pathways were clustered and analyzed in detail. Results: Among 1067 genes, 35 critical genes that are involved in the 14 highlighted biochemical pathways were recognized. Interpretation of the finding indicates that a number of central genes can be considered as potential biomarkers related to burn injury. Conclusion: Can we revise to â€œBurn injuries have features that are common to severalÂ diseases and increases their risk. [GMJ.2019;8:e1257]Â
Possible Role of Myopia as a Risk Factor for Mechanical Neck Pain in Medical Students: A Pilot Study
Authors: Kardeh Bahareh , Ashraf Alireza , Kardeh Sina 
Published: December 2023

Background: Mechanical neck pain (MNP) is a common health concern. Some studies suggested a relationship between neck pain and visual activity. We assessed the role of myopia as a contributing factor in the development of chronic MNP. Materials and Methods: All medical students at Shiraz University School of Medicine, who were 18 to 22 years old, were invited to participate in this retrospective case-control study from March 2016 to March 2017. Numeric Pain Rating Scale (NPRS) was used to assess the average neck pain severity over the past 6 months in order to enroll participants as the case (â‰¥3) or control (<3) groups. Demographic data and medical profile were obtained. After identifying eligible cases, we assigned age- and sex-matched controls, who also met the study criteria. Subsequently, participants completed the Neck Disability Index (NDI) and Neck Pain and Disability Scale (NPDS) questionnaires and were evaluated for myopia severity. Variables were compared between the case and control groups as well as within the case group. P-value<0.05 was considered statistically significant.Â Results: From over 700 medical students, around 150 cooperated. Eventually, 31 eligible cases (and 31 controls) were studied. NDI and NPDS were significantly higher in the case group (P<0.001). However, no significant differences were noticed between the groups regarding the severity (P=0.123) and the duration (P=0.417) of myopia. Also, the correlation of myopia severity with NDPS (Ï=0.159, P=0.216) and NDI (Ï=0.201, P=0.116) was non-significant within the case group.Â Conclusion: Our findings have not supported the influential role of myopia in the development of chronic MNP.Â [GMJ.2019;8:e1287]
Factors Influencing User Satisfaction with Information Systems: A Systematic Review
Authors: Kalankesh Leila R , Nasiry Zahra , Fein Rebecca , Damanabi Shahla 
Published: December 2023

User satisfaction has been considered as the measure of information system effectiveness success. User satisfaction is difficult to define but is considered an evaluation construct. Globally health organizations, particularly hospitals, invest a huge amount of money on information system projects. If hospital information systems (HISs) are to be successful, factors influencing or related to user satisfaction should be taken into account at the time of designing, developing or adopting such systems. The current study aimed to provide a comprehensive review of factors related to user satisfaction with information systems. The researchers systematically searched PubMed, Science Direct, and IEEE electronic databases for articles published from January 1990 to June 2016. A search strategy was developed using a combination of the following keywords: â€œmodel,â€ â€œuser satisfaction,â€ â€œinformation system,â€ â€œmeasurement,â€ â€œinstrument,â€ and â€œ tool.â€ Reported dimensions, factors, and their possible influence on user satisfaction with information systems were extracted from the studies wherever was possible. Overall factors influencing user satisfaction with information systems can be categorized in seven dimensions: Information quality, system quality, vendor support quality, system use, perceived usefulness, user characteristics, and organizational structure& management style. If all these factors are considered properly in the process of developing, designing, implementing, or purchasing information systems, the higher user satisfaction with the system will be likely. Otherwise, it would end up with unsatisfied users that will finally contribute to the system failure. [GMJ.2020;9:e1686]
A Life-Changing Moment in a Patient with Type 1 Diabetes: Insulin Holiday
Authors: Butt Muhammad Imran , Mukhtar Noha , Riazuddin Muhammad , Amer Lama , Elsayed Tarek 
Published: December 2023

Background: The diagnosis of type 1 diabetes can be a life-changing moment for our patients particularly having to live with the idea of taking insulin all their life and the barriers it can bring about. Case report: We report a patient with ten years of autoimmune type 1 diabetes treated with insulin. He was able to stop insulin in favour of oral diabetes agents after dynamic endocrine tests confirmed micro insulin secretion despite autoimmunity. Our case demonstrates that a detailed history and thorough investigations adopting a holistic approach can sometimes change the course of disease management and can leave a positive impact on the life of our patients. Conclusion: Patients with partial retention of beta-cell function in type 1 diabetes can temporarily stop insulin safely with ongoing surveillance. [GMJ.2020;9:e1769]
Comparison of Auditory Brain Stem Responses and Otoacoustic Emission of Autism with Healthy Children
Authors: Jabbari Moghaddam Yalda , Noorazar Seyed Gholamreza , Kharzaee Rasul , Sohrabpour Mojtaba 
Published: December 2023

Background: Autism is a neurodevelopment disorder, including difficulty in establishing relationships and social interaction, difficulty in communication, performing restricted, and repetitive behaviors. The impaired reception and integration of sensory information especially auditory data are one of the main characteristics of children with autism. According to various studies, the brain stem plays a key role in the reception and integration of auditory and sensory data. Hence, this study aims to comparison auditory brain stem responses (ABR) and otoacoustic emission (OAE) of autism patients with healthy children. Materials and Methods: This case-control study was performed on 20 autism children (4-8 years old) as case group who referred to psychiatry clinics affiliated with Tabriz University of Medical Sciences and 20 healthy age-matched as the control group. The severity of autism was evaluated by the Gilliam Autism Rating Scale (GARS). Also, ABR and OAE were recorded, and all data compared with the healthy children. Results: The latencies between the waves III-V and I-V bilaterally, and wave V bilaterally and wave I in the left ear showed a significant increase in children with autism compared to the healthy group. Conclusion: This study shows that there was a reduced nerve conduction velocity in the auditory pathway of the brain stem in children with autism compared to healthy children. [GMJ.2020;9:e1937]
Forecasting The Amount Of Oil and Non-Oil and Gas Exports In Indonesia Using The Box-Jenkins Method
Authors: Sinaga Anggita Br , Sari Riezky Purnama , Nurviana Nurviana 
Published: December 2023

Indonesia is one of the countries in Southeast Asia that has diversity and abundance of natural resources, both oil and gas and non-oil and gas. Export is an international trade activity that is profitable for economic growth in Indonesia. The purpose of this study is to determine the best results and models for oil and gas and non-oil and gas export data. The Box-Jenkins method (ARIMA) is a forecasting method that does not require or ignores independent variables. The stages used in the box-Jenkins method are identification of the model to see whether the model is stationary or not, for a model that is already stationary, a parameter estimation test will be carried out by looking at the significance value of the parameter, then a diagnostic check will be carried out using residual white noise and residual tests. normal distribution. After that, the initial prediction model is obtained and to get the best ARIMA model, it can be done by looking at the smallest MAPE value of each model. The best model obtained in this study to predict the amount of oil and gas and non-oil and gas exports in Indonesia uses the Box-Jenkins or ARIMA method, namely model (5,1,3) with the smallest MAPE of 8.142%. Forecasting results for the number of oil and gas and non-oil and gas exports in Indonesia in January - December 2023, namely: January 22194.9 million dollars, February 22795.6 million dollars, March 24796.0 million dollars, April 24106 million dollars, May 22281.6 million dollars, June 23186.6 million dollars, July 25184.3 million dollars, August 24325.8 million dollars, September 22456.3 million dollars, October 23565.6 million dollars, November 25602.2 million and December 24540.3 million dollars. Actual data or actual data for January – April 2023, namely January 22,323.8 million dollars, February 21,321.3 million dollars, March 23,416 million dollars, April 19,290.5 million dollars. It can be concluded that the results of the forecasting value of the box-Jenkins method are close to the actual value.
Effectiveness of Realistic Mathemathic Education (RME) Model Assisted With Jarimatics on Student Problem Solving
Authors: Mukaromah Mukaromah , Parmin Parmin , Prastiti Tri Diyah 
Published: December 2023

The objectives of this study are (1) to test the mathematical problem solving ability with RME learning model assisted by Jarimatika better than the mathematical problem solving ability with conventional learning, (2) to test the mathematical problem solving ability with RME model assisted by Jarimatika better than the mathematical problem solving ability with conventional learning, (3) to test the improvement of mathematical problem solving ability with RME model assisted by Jarimatika better than the improvement of mathematical problem solving ability with conventional learning. This research is a pure experimental research. The design was pre test post test control group design. The population was fifth grade students at Jatilawang 1 State Elementary School and Kemantran 1 and 2 State Elementary School. While the sample was first grade Jatilawang 1 State Elementary School as the experimental class and Kemantran 1 State Elementary School as the control class. Data collection techniques in this study were documentation and tests. The data analysis used in this research (1) mathematical problem solving ability completeness test (one sample t test) and classical completeness test, (2) mathematical problem solving ability average difference test (independent t test), and two proportion difference test, (3) mathematical problem solving ability improvement test. The results of this study are (1) The problem solving ability of students with the RME model assisted by teaching materials exceeds 70, and the proportion of students with the RME model assisted by teaching materials reaches the completion of problem solving ability exceeds 80%. (2) The problem solving ability of students with RME model assisted by teaching materials is better than the problem solving ability of students with conventional learning, and the proportion of students with RME model assisted by teaching materials achieving completeness of problem solving ability is more than or equal to students with conventional learning, (3) the improvement of students' problem solving ability with RME assisted by teaching materials is better than the improvement of students' problem solving ability with conventional learning, (4) the influence of curiousity on problem solving ability is 90%. The implication of this research is that the use of the RME model assisted by Jarimatics can develop problem solving abilities, problem solving abilities with the RME model assisted by Jarimatics are better than conventional models.
SPATIAL PLANNING AT THE LOCAL LEVEL IN UKRAINE
Authors: Нabrel Mykola , Habrel Mykhailo , Dobrovolska Marta , Forkutsa Lyudmila 
Published: December 2023

Spatial planning at the local level is given insufficient attention in research. In professional practice, this level of design is interpreted as a simple (sometimes "typical") design task, but it is at the local level that most mistakes and abuses are made. The tasks of spatial planning, regardless of the level of hierarchy, are inherently non-deterministic, complex, related to forecasting the development and improvement of the spatial future of territories. Therefore, the streamlining of scientific, methodological and practical provisions for the design of territorial systems at the local level will contribute to ensuring advanced local development. The authors characterized the state, identified the features and problems associated with spatial planning in Ukraine, and established the role of designing local scale objects in the current system. The experience of spatial planning in European countries, in particular in Poland, which can be useful in the systematic solution of the problems of restoration and development of communities, avoiding mistakes in this activity, is considered.
The characteristics for outlining the prospects for the spatial development of local systems, which include functionality, density, dynamism of space, development of the structure and are evaluated according to the following criteria: usefulness, economy, safety for people and the environment, duration of implementation of the proposal, are specified. The proposed spatial planning by the method of "counter flow" will help eliminate the problems of inconsistency of urban planning, land management and other strategic documents, as well as improve the quality of design solutions through integration and hierarchical coordination. The expediency and the way of transition from solving individual local tasks and problems to the integrated planning and development of territories of the highest hierarchy – systematization of information to substantiate decisions, taking into account intangible factors, their impact on development, which is complementary, interdependent, dynamic and closely integrated into the territory, are substantiated. Verification of these principles and approaches on local projects indicates their effectiveness and feasibility of using them in solving problems and at higher levels of the hierarchy. Approbation of design solutions for spatial planning at the local level is carried out on the example of the author's development of detailed plans of the territories of the industrial parks "Teresva" and "Kolomyia Industry".
REENGINEERING OF THE ACTIVITIES OF CONSTRUCTION PARTICIPANTS UNDER THE INFLUENCE OF DIGITALIZATION
Authors: Vakhovych Inna , Demianenko Oleksander , Bohatiuk Danylo 
Published: December 2023

The article researches the main trends in the digital transformation of the interaction of construction participants under the influence of digitalization. The peculiarity is that the directions and trends of digitalization are grouped in accordance with the stages of the life cycle of construction objects. The necessity of re-engineering the administrative-management interaction of construction participants has been identified, since the organizational structure of projects undergoes changes under the influence of digitalization, and accordingly the organizational and economic management mechanism of construction participants, in particular engineering companies, undergoes changes.
It was revealed that a great influence on the change of the principles and structure of administration of construction projects is carried out thanks to the use of systems of integrated management of construction projects, which are based on the use of VIM technologies. An overview of the modern software market was carried out. It was found that today the software market is filled with a large number of programs that are used to solve various problems of designing and transforming digital support in construction. The most common are software complexes for VIM design, automated general purpose design, design of building structures and geotechnical calculations, development of estimate documentation, development of calendar plans. Currently, all major developers of software complexes Autodesk, Trimble, SchneiderElectric, Graphisoft, etc. implement BIM technology in their products.
It is suggested that, when building the organizational and economic mechanism of modern engineering companies, take into account two main factors of the influence of digitalization in construction: the introduction of BIM technologies in the activities of design, construction and engineering companies, supported also at the state level, and digitalization of all processes related to the creation of a construction object - from obtaining technical conditions and urban planning restrictions to putting the facility into operation.
Mathematical modeling kinematics of double toggle jaw crusher
Authors: Mishchuk Yevgeny , Mishchuk Dmitry , Kapusta Оlga 
Published: December 2023

In this work, the problem of modeling the kinematic parameters of a jaw crusher with a simple movement of the jaw was consider. The dynamic model of the jaw crusher was consider as a flat articulated-lever closed mechanism. The crushing mechanism of the jaw crusher with a simple movement of the cheek modeled as a mechanism with five moving links and six rotary joints of the fifth mobility class, with the eccentric shaft modeled as a crank and the rotary jaw modeled as a rocker arm. The kinematic chain of the crank and the movable cheek was consider separately. Using vector equations, the interdependencies between the moving elements of the adopted kinematic scheme of the jaw crusher model were determined. Since this scheme has one degree of mobility, the functions of the position of all moving links of the given kinematic scheme were find, depending on the angle of rotation of the drive crank. Rotation angles was define in the Cartesian coordinate system relative to the horizontal plane.
In this work, using the obtained kinematic equations, the proposed simulation model of the jaw crusher was investigate and compared with a real SMD-117 machine using its typical dimensions.
The functions of the changes in the angles of rotation of the links of the kinematic scheme of the jaw crusher and their angular velocities obtained in the course of the research are important in the future for studies of the dynamics of such machine structures. Comparative data showed how the mechanism of changing kinematic parameters was implement in the design of the real SMD-117 machine.