bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global lineage evolution pattern of sars-cov-2 in Africa, America, Europe, and Asia: A comparative analysis of variant clusters and their relevance across continents
Authors: Hyug Choi June , Sook Jun Mee , Yong Jeon Jeong , Kim Hae-Suk , Kyung Kim Yu , Ho Jeon Chang , Hwan Choi Seock , Sun Kim Dong , Han Man-Hoon , Won Oh Ji 
Published: December 2023

Abstract

Objective
The objective of this study is to provide a comparative analysis of variant clusters and their relevance across Africa, America, Europe, and Asia, in order to understand the evolutionary patterns of the virus across different regions and to inform the development of targeted interventions and genomic surveillance eforts.

Methods
The study analyzed the global lineage evolution pattern of 74, 075 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from 32 countries across four continents, focusing on variant clusters and their relevance across regions. Variants were weighted according to their hierarchical level. The correlation between variants was visualized through Dimensionality reduction analysis and Pairwise Pearson's correlation. We presented a reconstructed phylogenetic tree based on correlation analysis and variant weights.

Results
The analysis revealed that each continent had distinct variant clusters and different evolutionary patterns. The Americas had two clustered variants before lineage divergence and a downstream confluence lineage, Europe had bifurcation into two global lineages with an early occurrence of certain cluster while Asia had a downstream confluence of two large lineages diverging by two distinct clusters. Based on the cluster patterns of shared variants of the SARS-CoV-2 virus, Africa demonstrated a relatively clear distinction among three distinct regions.

Conclusions
The study provides insights into the evolutionary patterns of SARS-CoV-2 and highlights the importance of international collaboration in tracking and responding to emerging variants. The study found that the global pandemic was driven by Omicron variants that evolved with significant differences between countries and regions, and with different patterns across continents.
Exosomes and their derivatives as biomarkers and therapeutic delivery agents for cardiovascular diseases: Situations and challenges
Authors: Xu Yunyang , Wan Weimin , Zeng Huixuan , Xiang Ze , Li Mo , Yao Yiwen , Li Yuan , Bortolanza Mariza , Wu Jian 
Published: December 2023

Abstract
Microvesicles known as exosomes have a diameter of 40 to 160 nm and are derived from small endosomal membranes. Exosomes have attracted increasing attention over the past ten years in part because they are functional vehicles that can deliver a variety of lipids, proteins, and nucleic acids to the target cells they encounter. Because of this function, exosomes may be used for the diagnosis, prognosis and treatment of many diseases. All throughout the world, cardiovascular diseases (CVDs) continue to be a significant cause of death. Because exosomes are mediators of communication between cells, which contribute to many physiological and pathological aspects, they may aid in improving CVD therapies as biomarkers for diagnosing and predicting CVDs. Many studies demonstrated that exosomes are associated with CVDs, such as coronary artery disease, heart failure, cardiomyopathy and atrial fibrillation. Exosomes participate in the progression or inhibition of these diseases mainly through the contents they deliver. However, the application of exosomes in diferent CVDs is not very mature. So further research is needed in this field.
What can a cryptogenic stroke hide in a young patient?
Authors: Cepoi Maria-Ruxandra , Vrabie Ioana Theodora , Ponor Cosmina , Nicolae Ana , Spiridon Marilena Renata , Petriș Antoniu Octavian , Costache Irina Iuliana 
Published: December 2023

Abstract

Introduction
Left ventricular hypertrabeculation is a recently described ventricular phenotype characterized by the alternation of excessive trabeculations with deep intertrabecular recesses that communicate with the left ventricular cavity but not with the coronary circulation.

Case presentation
We report the case of a young patient, recently diagnosed with ischemic stroke, in whom the cardiological assessment revealed the coexistence of left ventricular hypertrabeculation and dilated cardiomyopathy, which pathologies associated with a high risk of embolic events. The treatment administered followed the therapy for chronic heart failure, control of rhythm disorders that might occur, and the prevention of embolic accidents.

Conclusions
The particularity of the case is represented by atypical onset through a complication of the disease in a cardiovascular paucisymptomatic patient. Multimodal imaging corroborated with clinical and anamnestic elements had an essential role in the diagnosis.
Role of Food System Planning in Facilitating Local Food Procurement for School Meals
Authors: Blomley Elina , Soma Tammara , Callihoo Christine , Han Richard , Páez-Varas Claudia , Bodnar Chris , Li Belinda 
Published: December 2023

Farm to School (F2S) programs seeks to connect students with their local food system and community. Providing local food to schools, however, relies on the continuity of local food production in British Columbia (B.C.), as well as the capacity and willingness of farmers to support this “alternative market.” Planners have an important role to play in supporting farmers’ ability to sustain local food systems. At the provincial level, planning for farmland preservation through the Agricultural Land Reserve has helped to secure some of the farmland needed to support local food production into the future. However, preserving farmland is only one part of the solution to sustain local food systems. Drawing upon key informant interviews (n=21), this paper identifies planning-related barriers and opportunities for local food procurement in schools. This research emphasizes the invaluable roles that farmers, government, and planners can play in reimagining a just and sustainable food system transition.
Enhancing Quality Control of Packaging Product: A Six Sigma and Data Mining Approach
Authors: Ramadhani Resty Ayu , Fitriana Rina , Habyba Anik Nur , Liang Yun-Chia 
Published: December 2023

Six Sigma is of paramount importance to organizations as it provides a structured and data-driven approach, fostering continuous improvement, minimizing defects, and optimizing processes to meet and exceed customer expectations. In response to the increasing defects of packaging product in a cosmetics industry in Indonesia, surpassing the speciﬁed 3% tolerance limit, this research conducts a thorough investigation into the root causes, corrective measures, and improvement proposals to elevate product quality. By leveraging the Six Sigma method and data mining techniques, the study systematically addresses the complexities associated with defect reduction in packaging for cosmetics product. The research methodology encompasses deﬁning the problem through SIPOC and Critical to Quality (CTQ) diagrams, measuring via control charts and sigma level calculations, and analyzing using tools like pareto diagrams, Apriori algorithms, ﬁshbone diagrams, and Fault Mode and Eﬀect Analysis (FMEA). Key ﬁndings reveal a notable correlation between spot defects and varying colors, leading to pearl defects as identiﬁed by the Apriori algorithm. FMEA identiﬁes critical failures, including suboptimal printing plate conditions, clumpy ink usage, and insuﬃcient operator attention to ink ﬁlling. The improvement stage proposes practical solutions, such as implementing alarms and buzzers, color-indicator-adjusted ink storage labels, and a structured form for cleaning and monitoring printing plates. These ﬁndings carry signiﬁcant implications, providing a tailored roadmap for enhancing the quality of cosmetic packaging. The anticipated implementation of proposed improvements aims to elevate customer satisfaction by addressing speciﬁc pain points in the production process. Furthermore, the research contributes valuable insights to the broader cosmetics industry, oﬀering eﬀective methodologies for defect reduction and quality enhancement in packaging processes.
Novas perspectivas no manejo da cirrose: foco na terapia com betabloqueadores não seletivos e o impacto na hipertensão portal
Authors: Oliveira Guilherme da Silva , Machado Luiza Preato , Penha Tainara Paula da Anunciação , Barros Gabriela Orsi Meireles de , Silva Elizandra Franciele Fernandes da , Lemos Larah Chabudt , Lemos Ana Clara Chabudt , Santos Erwalber Mendes dos , Bolzan Lara Gonçalves de Moraes , Silveira Amanda Carolina Zicatti da 
Published: December 2023

Objetivo: Avaliar a efetividade da utilização de medicamentos Betabloqueadores Não Seletivos (BBNS) no tratamento de pacientes com cirrose hepática, incluindo complicações como hipertensão portal e sangramento por varizes esofágicas. Métodos: Revisão bibliográfica integrativa no PubMed Central (PMC) através da estratégia de pesquisa: (("Adrenergic beta-Antagonists"[MeSH]) OR (Nonselective beta-blockers) OR (Non-Selective Beta-Blockers) OR (Non-Selective β-Blockers) OR (Beta-Blockers) OR (β-Blockers)) AND ((Chirrosis) OR ("Hypertension, Portal"[MeSH])). Após a busca inicial, 174 estudos foram identificados, e submetidos a critérios de seleção. Após a aplicação de critérios de inclusão e exclusão, 14 artigos foram selecionados para compor este estudo. Resultados: Analisaram-se as duas principais abordagens para a prevenção de complicações decorrentes da cirrose, a intervenção farmacológica com BBNS, que demonstrou significativamente reduzir a chance de eventos adversos em comparação com a abordagem sem tal intervenção; e a administração de Beta Bloqueadores Não Seletivos, que foi associada a essa redução de riscos, sendo influenciada por fatores como maior eficácia de tratamento, além de redução de eventos desfavoráveis e prevenção de complicações decorrentes da doença. Considerações Finais: Estudos sugerem maior eficácia ao utilizar tais intervenções, entretanto, ainda é necessário mais pesquisas para garantir a completa redução de danos para tais pacientes.
Masalah Sosial Dalam Novel "Kami Bukan Sarjana Kertas" Karya J. S. Khairen
Authors: Wati Lia , Wulandari Giri , Sunarsih Eti , Triani Susan Neni 
Published: December 2023

<p>Tujuan penelitian untuk 1) Pendeskripsian masalah kemiskinan dalam novel Kami Bukan Sarjana Kertas karya J. S Khaireen 2) Pendeskripsian masalah pelanggaran terhadap norma-norma masyarakat dalam novel Kami Bukan Sarjana Kertas karya J. S Khaireen 3) Pendeskripsian masalah disorganisasi keluarga dalam novel Kami Bukan Sarjana Kertas karya J. S Khaireen 4) Pendeskripsian masalah kejahatan dalam novel Kami Bukan Sarjana Kertas karya J. S Khaireen 5) Implementasi masalah sosial terhadap pembelajaran bahasa dan sastra Indonesia dengan mengajarkan siswa menyelesaikan masalah yang terjadi di lingkungan. Peneliti menggunakan metode deskriptif yakni penggambaran pada subjek dan objek yang diteliti menggunakan kata-kata. Bentuk penelitian yang digunakan peneliti adalah bentuk penelitian kualitatif dengan pendekatan sosiologi sastra. Adapun hasil dari penelitian ini berupa masalah kemiskinan 11 data, pelanggaran terhadap norma-norma masyarakat 13 data, disorganisasi keluarga 7 data, dan kejahatan 8 data. Seluruh masalah yang didapatkan sebanyak 39 data.</p><p> </p>
Penggunaan Majas dalam Kumpulan Puisi Konde Penyair Han Karya Hanna Fransisca
Authors: Yanti Lili , Rinita Dwi Anggraini , Susanto Heru 
Published: December 2023

Penelitian ini bertujuan untuk mendeskripsian penggunaan majas perbandingan dalam kumpulan puisi <em>Konde Penyair Han </em>karya Hanna Fransisca, mendeskripsian penggunaan majas sindiran dalam kumpulan puisi <em>Konde Penyair Han </em>karya Hanna Fransisca,<strong><em> </em></strong>mendeskripsian penggunaan majas pertentangan dalam kumpulan puisi <em>Konde Penyair Han </em>karya Hanna Fransisca, mendeskripsian penggunaan majas penegasan dalam kumpulan puisi <em>Konde Penyair Han </em>karya Hanna Fransisca, mendeskripsian implementasi hasil penelitian pada rencana pembelajaran di sekolah. Metode Penelitian ini menggunakan metode deskriptif dengan bentuk penelitian kualitatif. Sumber data penelitian ini adalah puisi <em>Konde Penyair Han</em> karya Hanna Fransisca dan data dalam penelitian ini berupa larik-larik puisi, kata, frasa, kalimat yang mengacu pada penggunaan majas. Teknik pengumpulan data yang digunakan adalah studi dokumenter serta catat dan alat yang digunakan adalah peneliti sendiri sebagai instrumen kunci. Data dalam penelitian ini adalah larik-larik puisi konde penyair han karya Hanna Fransisca. Berdasarkan penelitian yang telah dilakukan diperoleh majas yang dibagi menjadi 4 meliputi Majas Perbandingan yaitu alegori 3, metafora 7, simbolik 8, personifikasi 4, hiperbola 9, sinestesia 3, litotes 2, antonomasia 1, totum pro parte 1. Majas sindiran yaitu ironi 10, sinisme 2, satire 3, inneundo 1. Majas pertentangan yaitu anakronisme 1, hipalase 1 data. Majas penegasan yaitu repetisi 3, pararima 4, aliterasi 4, paralelisme 4, tautologi 1, anafora 3, epistrofa 1, mesodiplosis 1, anadipolesis 3, epizeukis 1, retoris 2, asonansi 4, epanalepsis 1, ekskalamasio 2.
Consideraciones en torno a la cuestión de la subjetividad en el Lukács de Historia y conciencia de clase
Authors: Aragüés Estragués Juan Manuel 
Published: December 2023

Historia y conciencia de clase inaugura la reflexión sobre la subjetividad en el marxismo, recogiendo, de este modo, las orientaciones que Marx había ido perfilando a lo largo de su obra y abriendo la puerta a posteriores intentos de desarrollo de una teoría del sujeto en el seno del marxismo. A pesar del incuestionable mérito del aporte lukácsiano, sin embargo defenderemos que su aproximación a la subjetividad está teñida del mismo determinismo mecanicista que él reprocha al marxismo contemporáneo.
Avaliação da qualidade da água no perímetro urbano de Riachão do Jacuípe, Bahia, Brasil (Assessment water quality in urban perimeter of Riachão Jacuípe, Bahia, Brazil)
Authors: Carneiro Santiago Bruno Elton , De Jesus Taise Bomfim , Dos Santos Luciana Bagdeve de Oliveira 
Published: December 2023

Este artigo refere-se à avaliação da qualidade da água no perímetro urbano de Riachão do Jacuípe, Bahia-Brasil, através da determinação de parâmetros físico-químicos e microbiológicos, cálculo do índice de qualidade de água (IQA) e a modelagem da qualidade da água através do índice de qualidade da água (IQA), formulado pela National Sanitation Foundation (NSF). Foram realizadas 3 campanhas de coleta entre novembro de 2013 e fevereiro de 2014 nas quais foram determinados os seguintes parâmetros para o cálculo do IQA/NSF: Oxigênio Dissolvido (OD), Demanda Bioquímica de Oxigênio (DBO), nitrogênio total, fósforo total, turbidez, temperatura, sólidos totais (ST), pH e coliformes termotolerantes. Os resultados do IQA/NSF mostraram que as localidades de Nova Esperança, Barragem, Bela Vista, Traz da Roça e Laranjeira apresentaram qualidade da água regular, no período de novembro de 2013 a fevereiro de 2014, enquanto o Alto do Cruzeiro, Ponte Alto do Cruzeiro, Alto do Cemitério, Ranchinho, Rio Verde/Jacuípe, Jatobá e Barra apresentaram qualidade da água ruim, no período de novembro de 2013 a fevereiro de 2014. Os resultados das análises do IQA/NSF apontaram para uma maior poluição hídrica nas localidades que se encontram dentro da cidade, estando associadas à disposição de resíduos sólidos e efluentes domésticos “in natura” no ambiente fluvial. A B S T R A C T This article refers to the assessment of water quality in the urban perimeter of Riachão Jacuípe, Bahia-Brazil through the determination of physico-chemical and microbiological parameters, the calculation of water quality index (WQI) and the modeling of water quality. The strategy of choice of collection sites involved the selection of spots upstream and downstream of urban occupation. Three collecting campaigns between November 2013 and February 2014 were conducted, in which the following parameters were determined for the calculation of the IQA/NSF: ​​DO, BOD, total nitrogen, total phosphorus, turbidity, temperature, total dissolved solids, pH, and thermotolerant coliform. The results of the IQA/NSF showed that the towns of Nova Esperança, Barragem, Bela Vista, Traz da Roça and Laranjeira had regular water quality, while Alto do Cruzeiro, Ponte Alto do Cruzeiro, Alto Cemitério, Ranchinho, Rio Verde /Jacuípe, Jatobá and Barra showed poor water quality in between November 2013 and February 2014. Results of analyzes of the IQA/NSF pointed out an increased water pollution in the localities that lie within into towns and are associated with the disposal of solid waste and domestic sewage ";in natura ";in the fluvial environment. Key words: Environmental modeling, water pollution, WQA
Pengembangan Modul Pembelajaran Kimia SMA/MA Berbasis Kontekstual Pada Pokok Bahasan Larutan Elektrolit Dan Nonelektrolit
Authors: Sakmawati Sakmawati , Muti’ah Muti’ah , Hadisaputra Saprizal 
Published: December 2023

Penelitian ini merupakan penelitian pengembangan atau R&D (Research and Development) yang bertujuan untuk mengetahui tingkat kelayakan dan kepraktisan modul pembelajaran kimia SMA/MA berbasis kontekstual pada pokok bahasan larutan elektrolit dan nonelektrolit. Design penelitian yang digunakan adalah model 4D (define, design, development, and dissemination). Populasi penelitian sebanyak 116 peserta didik dengan jumlah sampel 38 peserta didik kelas X IPA 3 dan IPA 4 MA NW Narmada dengan pengambilan secara acak dan dijadikan responden untuk uji coba terbatas. Hasil penelitian menunjukkan tingkat validasi modul pembelajaran dari tiga orang validator yang diperoleh menggunakan indeks Aiken adalah V = 0,84 dan perolehan tingkat praktikalitas dilihat dari respon peserta didik dan guru menunjukkan respon positif dengan masing-masing tingkat kepraktisan sebesar 86,44% untuk peseta didik dan dari guru sebesar 94,49%. Berdasarkan hasil yang diperoleh dapat disimpulkan bahwa modul pembelajaran yang dikembangkan memenuhi kriteria yakni sangat layak dan sangat praktis digunakan dalam proses pembelajaran.
Kata Kunci: Pengembangan, Modul Pembelajaran, Larutan Elektrolit dan Nonelektrolit.
ESTUDOS E PESQUISAS EM EDUCAÇÃO COMPARADA
Authors: Souza Aléxia Maria Lopes de 
Published: December 2023

Resenha do seguinte livro:
Título da obra: Pesquisa em Educação Comparada: abordagens e métodos
Autor(es): Mark Bray, Bob Adamson e Mark Mason
Edição: Segunda edição
Editora: Liber Livro
Cidade: Brasília
Ano: 2015
Número de páginas: 488
Optimisation of Approaches to Adverse Event Analysis in Bioequivalence Clinical Trials
Authors: Verveda A. B. , Vasilyuk V. B. , Syraeva G. I. , Faraponova M. V. 
Published: December 2023

SCIENTIFIC RELEVANCE. The safety assessment of investigational medicinal products is a mandatory step in clinical trials of all phases, including bioequivalence studies. However, there are no approaches providing for the individualised assessment of adverse drug reactions (ADRs), which contributes to the quality of decisions on the safety of pharmacotherapy.AIM. The study aimed to develop and justify approaches to the individualised assessment of the safety of pharmacotherapy based on quantitative integrative analysis of adverse events (AEs).MATERIALS AND METHODS. The authors carried out a systematic review of open-access publications and adapted quantitative integrative analysis methods for assessing the safety of pharmacotherapy in clinical trials involving healthy volunteers. The developed methodology is a step-by-step individualised assessment of ADRs, where each case is assigned a certain score and a weight, with subsequent data aggregation to obtain an integrated indicator at the system/organ and organism levels.RESULTS. The authors developed a five-step procedure for assessing the safety of pharmacotherapy based on quantitative integrative ADR analysis. This procedure involves scoring an AE, converting the score using membership functions, assigning weights, aggregating data to obtain an integrated indicator, and interpreting individual and group indicators. The sequential implementation of the analysis steps in accordance with the proposed procedure makes it possible to assign each volunteer (study subject) to a specific group in accordance with the likelihood of developing AEs. In addition to individual assessment, the article presents an algorithm for interpreting indicators for groups of study subjects, depending on the treatment group (study or comparator medicinal product).CONCLUSIONS. The described algorithm for converting and presenting integrative AE assessments will improve the reliability and validity of conclusions on the safety of medicinal products, which is important for planning and implementing further clinical development programmes.
The Irkutsk focus of opisthorchosis (to the 40th Anniversary of the discovery)
Authors: Rusinek O. T. , Veprikov S. P. 
Published: December 2023

The purpose of the research is to summarize our own and literature data on the Irkutsk focus of opisthorchosis.Materials and methods. The materials (mollusks, cyprinids and muskrat) were collected in the reservoirs of the Biryusa River basin. Mollusks were identified using the key by Ya. I. Starobogatova et al. (2004). The fish were studied for metacercariae of the trematode Opisthorchis felineus using the conventional compression method according to the recommendations and using the method of digestion with artificial gastric juice.Results and discussion. According to our own and literature data, there is a focus of mixed type opisthorchosis in the Taishetsky District, the Irkutsk Region, in which the final hosts of the parasite are wild animals, namely, the muskrat, along with domestic animals (cats) and humans. The first intermediate host is Opisthorchophorus troscheli. The second intermediate hosts are four fish species (roach, dace, crucian carp, and bream); minnow and tench were not infected with Opisthorchis sp. Mapping of current data has showed its distribution in the Biryusa River basin. The current state of knowledge for the Irkutsk focus of opisthorchosis shows that a comprehensive research plan is needed with the participation of scientific and regulatory institutions of the Irkutsk Region and Taishetsky District.