bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concordance of Immunohistochemistry and Fluorescence In Situ Hybridization in the Detection of Anaplastic Lymphoma Kinase (ALK) and Ros Proto-oncogene 1 (ROS1) Gene Rearrangements in Non–Small Cell Lung Carcinoma: A 4.5-Year Experience Highlighting Challenges and Pitfalls
Authors: Nambirajan Aruna , Sood Ridhi , Khatoon Warisa , Malik Prabhat Singh , Mohan Anant , Jain Deepali 
Published: December 2023

Context.—
ALK and ROS1 rearrangements are essential biomarkers to be tested in advanced lung adenocarcinomas. While D5F3 Ventana assay is a companion diagnostic for anaplastic lymphoma kinase–targeted therapy, immunohistochemistry is only a screening tool for detecting ROS1 rearrangement. Confirmation by cytogenetic or molecular techniques is necessary.

Objective.—
To evaluate the utility of ALK and ROS1 fluorescence in situ hybridization as a complement to immunohistochemistry in routine predictive biomarker testing algorithms.

Design.—
The study was ambispective, spanning 4.5 years during which lung adenocarcinoma samples were subjected to EGFR mutation testing by real-time polymerase chain reaction and ALK/ROS1 rearrangement testing by immunohistochemistry (Ventana D5F3 assay for anaplastic lymphoma kinase protein; manual assay with D4D6 clone for Ros proto-oncogene 1 protein). Fluorescence in situ hybridization was performed in all anaplastic lymphoma kinase equivocal and Ros proto-oncogene 1 immunopositive cases.

Results.—
Of 1874 samples included, EGFR mutations were detected in 27% (481 of 1796). Anaplastic lymphoma kinase immunohistochemistry was positive in 10% (174 of 1719) and equivocal in 3% (58 of 1719) of samples tested. ALK fluorescence in situ hybridization showed 81% (77 of 95) concordance with immunohistochemistry. Ros proto-oncogene 1 immunopositivity was noted in 13% (190 of 1425) of cases, with hybridization-confirmed rearrangements in 19.3% (26 of 135) of samples, all of which showed diffuse, strong- to moderate-intensity, cytoplasmic staining in tumor cells. Ros proto-oncogene 1 protein overexpression without rearrangement was significantly common in EGFR-mutant and ALK-rearranged adenocarcinomas.

Conclusions.—
Immunostaining is a robust method for ALK-rearrangement testing, with fluorescence in situ hybridization adding value in the rare equivocal stained case. ROS1-rearrangement testing is more cost-effective if immunohistochemistry is followed by fluorescence in situ hybridization after excluding EGFR-mutant and ALK-rearranged adenocarcinomas.
The Quest for Quality in University Education in the Post-COVID-19 Era
Authors: Kavulya Joseph M. , Kiilu Vincent Bob , Kyengo Bernadetta N. 
Published: December 2023

Plagiarism is a major global challenge to quality assurance in higher education. Various efforts have been made to overcome the menace including the use of anti-plagiarism tools. At the same time, many questions have been raised about the efficacy of the current generation of tools in detecting, preventing plagiarism, and guaranteeing the quality of education. This paper examines the limitations of plagiarism detection tools in enhancing the quality of academic outcomes and proposes measures for improvement. The paper argues that while anti-plagiarism software has a role in preventing plagiarism in academic writing and academic integrity, they are not the panacea to the plagiarism pandemic, especially in the COVID-19 era. It proposes that there is a need to reform methods of assessment and implement forward-looking policies to address the underlying causes of plagiarism, provide students with appropriate information literacy skills training, and above all cultivate a culture of academic integrity in higher education institutions (HEIs).
ANALISIS PENILAIAN KINERJA DENGAN METODE BALANCED SCORECARD PADA ORGANISASAI BISNIS
Authors: Mujiati Ni Wayan , Kartika Dewi A. A Sagung , Sriathi A. A Ayu 
Published: December 2023

Performance is a level of achievement description from implementationof an activity/ a policy program in achieving target, goal, mission, and vision whichis outlined in strategic planning of an organization. Performance assessment is aperiodically determination of operational effectiveness of an organization, part oforganization and its personnel, based on the target, standard and criteria predefined.Organization is a system consists of cooperation activity pattern which is doneregularly and repeatedly by a group of people to achieve a certain goal. Business isan organized individual business activity to produce and sell goods and services togain profit in fulfilling the peopleâ€™s needs. Balanced scorecard is a new frameworkto interact various dimensions that are obtained
strategy; measuring the companyperformance to four balance perspectives, they are:
finance, customer, internalbusiness process and learning and growth.
Abus et violence vécus par les jeunes trans et non binaires au Québec
Authors: Ladry Naomie-Jade , Pullen Sansfaçon Annie , Chadi Nicholas , London-Nadeau Kira , Taylor Ashley B. , Chan Ace , Chiniara Lyne , Saewyc Elizabeth M. 
Published: December 2023

Les jeunes s’identifiant comme étant des personnes trans ou non binaires (TNB) sont
exposé·e·s au risque de vivre différentes formes de discrimination, d’abus et de violence de
la part des membres de leur famille ou de leur entourage. Cet article a pour but de : 1)
faire un portrait des jeunes TNB ayant vécu un ou des types d’abus ; 2) cerner le contexte
particulier de cette violence et de ses répercussions sur le bien-être des jeunes TNB. Les
données ont été recueillies dans le cadre de « l’Enquête canadienne sur la santé des jeunes
trans et non binaires » (ECSJT) menée au pays en 2019. L’échantillon est composé de
220 jeunes TNB âgé·e·s de 14 à 25 ans résidant dans la province de Québec. Des analyses de
Test T et Chi carré ont été menées. Elles montrent que près de la moitié de l’échantillon a
subi des violences sexuelles (44,1 %) et près de 20 % de l’échantillon a été blessé
physiquement par un membre de la famille, phénomène plus fréquemment rencontré chez les 14 à
17 ans (34,2 %) que chez les 18 à 25 ans (14,6 %). En contrôlant pour l’âge, il y avait une
association significative entre les liens familiaux et les chances d’être victime (p
<.001) ou d’avoir été témoin (p =.03) de violences impliquant un·e membre de la famille.
Les résultats de l’enquête en ligne sont cohérents avec les différentes études soulignant
les abus et la violence vécus par les jeunes des minorités sexuelles.
Portrait des activités d’accueil et de promotion des services dans les bibliothèques
parlementaires canadiennes
Authors: Ménard Carolyne , Blandford Alieda , Boily-Bernal Mirabelle , Côté François , Gaudet Kathleen , Giese Michelle , Hyde Andrea , Reddin Ryan , Smith Erica ,   Bibliothèque de l’Assemblée législative de
        l’Alberta
Published: December 2023

Les bibliothèques parlementaires sont confrontées à un changement périodique de
leurs clientèles politiques en fonction du cycle électoral. L’accueil d’une nouvelle
législature est par conséquent un événement crucial pour ces institutions ; il est alors
essentiel de promouvoir leurs services pour montrer leur utilité aux nouveaux
parlementaires. Qui plus est, les parlementaires ne sont souvent pas conscients de l’étendue
des services offerts par les bibliothèques parlementaires, dont l’offre de services diffère
des milieux documentaires communs. Cet article présente un aperçu des initiatives
entreprises par les bibliothèques parlementaires canadiennes lors de l’accueil d’une
nouvelle législature, ainsi que des activités de promotion utilisées pour faire connaître
leurs services à la nouvelle députation et au nouveau personnel politique.
Patterns of Telemedicine Use and Glycemic Outcomes of Endocrinology Care for Patients With Type 2 Diabetes
Authors: Zupa Margaret F. , Vimalananda Varsha G. , Rothenberger Scott D. , Lin Jonathan Y. , Ng Jason M. , McCoy Rozalina G. , Rosland Ann-Marie 
Published: December 2023

ImportanceTelemedicine can increase access to endocrinology care for people with type 2 diabetes (T2D), but patterns of use and outcomes of telemedicine specialty care for adults with T2D beyond initial uptake in 2020 are not known.ObjectiveTo evaluate patterns of telemedicine use and their association with glycemic control among adults with varying clinical complexity receiving endocrinology care for T2D.Design, Setting, and ParticipantsRetrospective cohort study in a single large integrated US health system. Participants were adults who had a telemedicine endocrinology visit for T2D from May to October 2020. Data were analyzed from June 2022 to October 2023.ExposurePatients were followed up through May 2022 and assigned to telemedicine-only, in-person, or mixed care (both telemedicine and in-person) cohorts according to visit modality.Main Outcomes and MeasuresMultivariable regression models were used to estimate hemoglobin A1c (HbA1c) change at 12 months within each cohort and the association of factors indicating clinical complexity (insulin regimen and cardiovascular and psychological comorbidities) with HbA1c change across cohorts. Subgroup analysis was performed for patients with baseline HbA1c of 8% or higher.ResultsOf 11 498 potentially eligible patients, 3778 were included in the final cohort (81 Asian participants [2%], 300 Black participants [8%], and 3332 White participants [88%]); 1182 used telemedicine only (mean [SD] age 57.4 [12.9] years; 743 female participants [63%]), 1049 used in-person care (mean [SD] age 63.0 [12.2] years; 577 female participants [55%]), and 1547 used mixed care (mean [SD] age 60.7 [12.5] years; 881 female participants [57%]). Among telemedicine-only patients, there was no significant change in adjusted HbA1c at 12 months (−0.06%; 95% CI, −0.26% to 0.14%; P = .55) while in-person and mixed cohorts had improvements of 0.37% (95% CI, 0.15% to 0.59%; P &amp;lt; .001) and 0.22% (95% CI, 0.07% to 0.38%; P = .004), respectively. Patients with a baseline HbA1c of 8% or higher had a similar pattern of glycemic outcomes. For patients prescribed multiple daily injections vs no insulin, the 12-month estimated change in HbA1c was 0.25% higher (95% CI, 0.02% to 0.47%; P = .03) for telemedicine vs in-person care. Comorbidities were not associated with HbA1c change in any cohort.Conclusions and RelevanceIn this cohort study of adults with T2D receiving endocrinology care, patients using telemedicine alone had inferior glycemic outcomes compared with patients who used in-person or mixed care. Additional strategies may be needed to support adults with T2D who rely on telemedicine alone to access endocrinology care, especially for those with complex treatment or elevated HbA1c.
Physiologic responses of Cownose Rays following freshwater dips for treatment of capsalid monogeneans
Authors: Lum Amber M. , Miller Sarah N. , Clauss Tonya M. , Anderson Chelsea E. 
Published: December 2023

Abstract

Objective
Two Cownose Rays Rhinoptera bonasus were presented for management of a severe capsalid monogenean infection Benedeniella posterocolpa in a mixed species habitat at an aquarium.

Methods
A series of freshwater (FW) dips were elected to mitigate parasite resistance to praziquantel due to the endemic monogenean population in the system. A pretreatment blood sample was opportunistically obtained, and subsequent samples were processed due to development of clinical signs.

Result
While the first FW dip was tolerated well and did not induce abnormal behavior, the second led to one individual presenting with tachypnea, pallor, and lethargy. Marked hematological abnormalities requiring medical intervention occurred in both individuals after the second dip. After treatment with elasmobranch Ringer's fluid therapy, sodium bicarbonate, prednisolone acetate, and vitamin E/selenium in the more severely affected ray, and elasmobranch Ringer's alone in the second ray, hematologic derangements and symptoms resolved. Hemoconcentration, hyperproteinemia, hyperlactatemia, and hyperglycemia were attributed to a stress response. A selective loss of urea after exposure to FW resulted in decreased plasma osmolality.

Conclusion
Given the severity of the stress response and associated complications observed, hyposalinity treatments should be utilized with caution in this species. If this therapy is employed, the clinician is advised to be prepared to administer supportive care coinciding with the FW dip if necessary.
Solution to delayed linear discrete system with constant coefficients and second‐order differences and application to iterative learning control
Authors: Yang Maosong , Fečkan Michal , Wang JinRong 
Published: December 2023

SummaryIn this article, we give an alternative representation and prior estimation of solution to delayed linear discrete systems with a second‐order difference with the help of the notation of delayed discrete matrix functions via their norm estimations. As an application, this solution is used to study iterative learning control under the suitable updating laws and sufficient conditions to guarantee that asymptotic convergence tracking results are presented. Finally, two numerical examples are given to verify the theoretical results.
The Use of Acellular Tissue Matrices in Gender‐Affirming Surgery: Review of the Literature and Institutional Experience
Authors: Alba Brandon , Weinstein Brielle , Arnold Sydney H. , Jacobs Kristin M. , Schechter Loren 
Published: December 2023

AbstractWound healing complications are not uncommon after genital gender‐affirming surgery and can pose significant challenges for the reconstructive surgeon. Acellular tissue matrices are products that contain extracellular matrix compounds without living cells and are used to expedite and improve wound healing. Some of these products have been described for a variety of different indications in gender‐affirming surgery. In this paper, the authors present a review of the current literature on the use of acellular tissue matrices in gender‐affirming surgery as well as the authors’ institutional experience in using these products.
Correlation Between Structural Features and Magnetic Performance of Fe93.5Si6.5 (wt.%) Soft Magnetic Materials
Authors: Yang Jing , Fu Zongwen , Wahl Larissa , Travitzky Nahum , Körner Carolin 
Published: December 2023

AbstractLaminated, powder filled, and dense bulk soft magnets are currently used for various electrical and electronic applications due to their characteristic magnetic properties. In order to systematically investigate the correlation between the structural features and the resulting magnetic performance of various soft magnetic materials, toroidal Fe93.5Si6.5 (wt.%) specimens with “layer structure”, “powder structure”, and “dense structure” are additively manufactured and characterized by means of electron beam powder bed fusion (PBF‐EB). The specimens with “layer structure” show outstanding magnetic performance in terms of low power losses and good maximum magnetic flux density at frequencies ranging from 50 to 1000 Hz, outperforming even some soft magnetic materials fabricated using conventional methods. Fe93.5Si6.5 (wt.%) specimens with various layered structures are produced using different processing strategies, allowing for sophisticated structural tailoring, and modifying the corresponding magnetic performance. Based on the results derived in this study, an ideal structure that can result in superior soft magnetic properties is proposed.
Engineering Carbon Nanotube‐Based Photoactive COF to Synergistically Arm a Multifunctional Antibacterial Hydrogel
Authors: Lin Xiaojun , Zhang Meng , Lv Wenxin , Li Jing , Huang Rong , Wang Yi 
Published: December 2023

AbstractEnhancing the covalent organic framework (COF)’s photocatalytic ability synergistically with gelling formulations remains an urgent challenge for extended bio‐applications. Herein, COF is homogeneously coated on an oxidized carbon nanotube (OCNT) and coordinated by Fe3+ to obtain tubular nanocomplex OCNT@COF‐Fe (O@CF). The results showed that the photodynamic reactive oxygen species (ROS) generation ability of O@CF is enhanced due to the wrapped OCNT and the coordinated Fe3+, which can respectively serve as intermolecular charge transfer channel and electron acceptors/substrates (O2 and H2O) adsorbent to narrow the energy band gaps, increase the light absorption, and decrease the photogenerated carrier recombination. Synergistically, O@CF exhibited pH‐dependent peroxidase and catalase activities, which further enhanced ROS generation and relieved hypoxia, respectively. Meanwhile, O@CF possessed degradation of COF coatings‐dependent photothermal performances. Then, O@CF is evenly incorporated into Schiff base hydrogel via the COF coating‐participated covalent cross‐linking, to obtain an electroconductive hydrogel OCNT@COF‐Fe@Gel (O@CF@G). This O@CF@G can not only improve the mechanical properties of pure gel but also inherit the multifunction of O@CF. Consequently, it can well adhere to diabetic wounds for imbibition, drug‐resistant biofilm elimination, gram‐positive and negative bacteria killing, hypoxia alleviation, and intercellular electrical signal conduction, thus accelerating wound healing.
Hollow‐Micropillared Glass Fabricated on Hollow Joe Pye Weed‐Inspired Tubes for Detecting Molecular Signatures
Authors: Novikova Anastasia L. , Katiyi Aviad , Sheintop Uzziel , Zhang Meng , Wang Pengfei , Karabchevsky Alina 
Published: December 2023

AbstractA rational design and fabrication approach is proposed for suspended multicore fibers, resulting in the creation of dual‐core and triple‐core suspended fibers with different diameters and one‐side cladding. These fibers are tailored for near‐infrared spectroscopy applications. The multicore‐suspended fibers offer an amplified electromagnetic field effect due to the exposure of the core to the analyte, leading to a significant 16 dB drop in transmittance at the fingerprint absorption line of the analyte. Numerical models indicate that the suspended core with a diameter of 3.52 m exhibits a superior evanescent field in the boundary between the core and the contact point with the cladding, in comparison to the tested cores with diameters of 3.99 and 12.06 m. The successful fabrication of these multicore‐suspended fibers represents a promising advancement toward achieving highly sensitive molecular signature detection capabilities.
Bionic Adhesion Systems: From Natural Design to Artificial Application
Authors: Qin Hengshen , Zhang Chuang , Tan Wenjun , Yang Lianchao , Wang Ruiqian , Zhang Yiwei , Wang Feifei , Liu Lianqing 
Published: December 2023

AbstractCreatures in nature perform a variety of activities through adhesion behavior, including moving flexibly and quickly on inclined and vertical walls and even ceilings. Studying the physical and chemical mechanisms underlying their adhesion behaviors can provide effective templates for applications such as climbing robots, grippers, and medical devices. This review summarizes various major types of adhesion that creatures rely on and their morphological structures that enhance adhesion, in addition to discussing their inspiration regarding the design of bionic adhesion systems. First, different adhesion types adopted by creatures in various natural environments are introduced, and the adhesion mechanisms and their theoretical models are summarized. Subsequently, the convergent evolution exhibited in biological adhesion structures is summarized from three perspectives: size limitation, compliance, and fluid transport. The development of the bionic design process wherein researchers imitate the natural biological adhesion process to create artificial adhesives is then presented regarding three mechanisms: chemical bonding adhesives, fiber arrays, and suckers. Fiber arrays are further divided into dry adhesives and wet adhesives. Finally, the shortcomings of the existing bionic adhesion systems and future trends are summarized.
Label‐Free Blood Typing by Raman Spectroscopy and Artificial Intelligence
Authors: Jensen Emil Alstrup , Serhatlioglu Murat , Uyanik Cihan , Hansen Anne Todsen , Puthusserypady Sadasivan , Dziegiel Morten Hanefeld , Kristensen Anders 
Published: December 2023

AbstractLabel‐free blood typing by Raman spectroscopy (RS) is demonstrated by training an artificial intelligence (AI) model on 271 blood typed donor whole blood samples. A fused silica micro‐capillary flow cell enables fast generation of a large dataset of Raman spectra of individual donors. A combination of resampling methods, machine learning and deep learning is used to classify the ABO blood group, 27 erythrocyte antigens, 4 platelet antigens, regular anti‐B titers of blood group A donors, regular anti‐A,‐B titers of blood group O donors, and ABH‐secretor status, from a single Raman spectrum. The average area under the curve value of the ABO classification is 0.91 ± 0.03 and 0.72 ± 0.09, respectively, for the remaining traits. The classification performance of all parameters is discussed in the context of dataset balance and antigen concentration. Post‐hoc scalability analysis of the models shows the potential of RS and AI for future applications in transfusion medicine and blood banking.
Dual Photoredox Catalysis with Vanadium Complexes in Low Oxidation State: Diastereoselective Pinacol Coupling
Authors: Pinosa Emanuele , Gelato Yuri , Calogero Francesco , Moscogiuri Matteo Maria , Gualandi Andrea , Fermi Andrea , Ceroni Paola , Cozzi Pier Giorgio 
Published: December 2023

AbstractDual photoredox catalysis is modifying the approach to sustainable metal catalysis based on metals in low oxidation state, as the use of stoichiometric metal as reductants are avoided. In this study, we showcase the potential use of vanadium in a dual photoredox process, allowing us to effectively control the formation of V(II) and its corresponding chemical reactions. A diastereoselective pinacol coupling with aromatic aldehydes is described. The process shows broad scope, and interestingly, unprotected salicylic aldehydes are compatible with the reaction protocol. Additionally, among all the ligands investigated we found that inexpensive bipyridines control the diastereoselection of the reaction favoring the d,l chiral compound (dr>20:1 for most of the aldehydes investigated). To promote the reaction and avoid an unproductive and not stereoselective radical coupling of the generated ketyl radical, the use of [DMQA]+, a stable organic dye, was found crucial. Furthermore, this dye possesses the remarkable capability of efficiently capturing light in the red segment of the visible spectrum, effectively raising efficiency of the protocol. The utilization of red light carries notable advantages in terms of penetration and safety, making it particularly significant. Moreover, careful photophysical investigations were able to give indications about the mechanism of the reaction.
Electrolyzer and Fuel Cell Recycling for a Circular Hydrogen Economy
Authors: Uekert Taylor , Wikoff Hope M. , Badgett Alex 
Published: December 2023

AbstractElectrolyzers and fuel cells will be crucial for achieving global clean hydrogen and industrial decarbonization goals. However, the nascent clean hydrogen sector faces uncertainties around material supply chains and technology end‐of‐life management. This work aims to guide the transition to a circular hydrogen economy by using process modeling, techno‐economic analysis, and life cycle assessment to evaluate the material cost, energy use, greenhouse gas (GHG) emissions, toxicity, and water use of five potential recycling strategies for proton exchange membrane electrolyzers (PEMWE) and fuel cells (PEMFC). Hydrometallurgy, acid dissolution, and electrochemical dissolution are shown to offer 2–7 times improvement across all assessed metrics relative to the manufacturing of PEMWE and PEMFC from raw materials. Recycling can also lower the raw material demand, material cost, energy use, and GHG emissions associated with PEMWE and PEMFC deployment in the United States in 2050 by 23%, 19%, 21%, and 16%, respectively. This study provides key insights into the costs, benefits, and complexities of recycling strategies for PEMWE and PEMFC, aiding the development of a circular economy that is synergistic with clean hydrogen deployment.