bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission
Authors: Ishida Natsuki , Ito Tatsuhiro , Takahashi Kenichi , Asai Yusuke , Miyazu Takahiro , Higuchi Tomohiro , Tamura Satoshi , Tani Shinya , Yamade Mihoko , Iwaizumi Moriya , Hamaya Yasushi , Osawa Satoshi , Sugimoto Ken 
Published: December 2023

BACKGROUND
Although the usefulness of endoscopic scores, such as the Mayo Endoscopic Subscore (MES), Ulcerative Colitis Endoscopic Index of Severity (UCEIS), and Ulcerative Colitis Colonoscopic Index of Severity (UCCIS), and biomarkers such as fecal calprotectin (FC) for predicting relapse in ulcerative colitis (UC) has been reported, few studies have included endoscopic scores for evaluating the entire colon.
AIM
To compare the usefulness of FC value and MES, UCEIS, and UCCIS for predicting relapse in patients with UC in clinical remission.
METHODS
In total, 75 patients with UC in clinical and endoscopic remission who visited our institution between February 2019 and March 2022 were enrolled. The diagnosis of UC was confirmed based on the clinical presentation, endoscopic findings, and histology, according to the current established criteria for UC. Fecal samples were collected the day before or after the colonoscopy for measurement of FC. Endoscopic evaluations were performed using MES, UCEIS, and UCCIS. The primary outcome measure of this study was the assessment of the association between relapse within 12 mo and MES, UCEIS, UCCIS, and FC. The secondary outcome was the comparison between endoscopic scores and biomarkers in enrolled patients with UC with mucosal healing.
RESULTS
FC and UCCIS showed a significant correlation with UCEIS (r = 0.537, P < 0.001 and r = 0.957, P < 0.001, respectively). Receiver-operating characteristic analysis for predicting MES 0 showed that the area under the curve of UCCIS was significantly higher than that of FC (P < 0.01). During the 1-year observation period, 18 (24%) patients experienced a relapse, and both the FC and UCCIS of the relapse group were significantly higher than that of the remission group. The cut-off values for predicting relapse were set at FC = 323 mg/kg and UCCIS = 10.2. The area under the curve of the receiver-operating characteristic analysis for predicting relapse did not show a significant difference between FC and UCCIS. The accuracy of the endoscopic scores and biomarkers in predicting relapse was 86.7% for UCCIS, 85.3% for UCEIS, 76.0% for FC, and 73.3% for MES.
CONCLUSION
The three endoscopic scores and FC may predict UC relapse during clinical remission. Among these scores, UCEIS may be the most useful in terms of ease of evaluation and accuracy.
Method of reinforcing defects in field welds of unique buildings and structures
Authors: Farfel M. I. , Gurov S. V. , Glazunov O. V. 
Published: December 2023

Introduction. The article presents a new method of reinforcing field welds with defects, impermissible according to the regulation requirements. This method allows reinforcement works to be carried out while maintaining the functional purpose of a building or structure without closing for the repair.Aim. To develop a technology of reinforcing defective welds, which preserves the functional purpose of a structure during repair works without its closure.Materials and methods. Reinforcement is carried out using a sheet of high-strength steel. The reinforcing sheet must be attached to connected field elements, which excludes the defective weld from the operation. Welders are permitted to perform works after testing on control welded joints. Welds, made by a candidate welder, is cut and sent to a specialized laboratory for determining weld strength properties, impact strength of weld macro- and microstructures, as well as the order and dimensions of legs for multi-pass welds. If the obtained weld data meets the standard indicators, the candidate welder is permitted to connect the reinforcement sheets of defective field welds. After making welded joints, they must be checked by visual, instrumental and ultrasonic testing.Results. A method of reinforcing defective welds was developed and implemented. Defects in the welds appeared during the connection of field elements, whose dimensions were less than the transport size, into a single spatial system, for example, the inner contour of a dome cover. This type of reinforcement can be made without closing the building or structure for repair works.Conclusion. The method of weld reinforcement can be used to remedy impermissible derects, detected by visual, instrumental and ultrasonic testing, in any buildings and structures, including unique long-span ones, therefore ensuring their reliable and safe operation after the construction.
Normal section strength of eccentrically compressed reinforced concrete structures with loop reinforcement joints. Experimental studies
Authors: Zenin S. A. , Kudinov O. V. , Kudyakov K. L. , Yurin E. Yu. , Khlebnikov S. K. 
Published: December 2023

Introduction. The current RF regulatory documentation contains only general instructions on the structural requirements for loop reinforcement joints in reinforced concrete structures without accounting their influence on the bearing capacity of normal sections, in particular, eccentrically compressed elements. These circumstances limit designers and may have a negative effect on the reliability of design solutions. In this regard, it seems necessary to investigate various possible structural options of loop joints and experimentally check their effect on the normal section strength of eccentrically compressed elements under static loads.Aim. To conduct experimental studies of the bearing capacity for normal sections of eccentrically compressed reinforced concrete elements with various options of loop reinforcement joints.Materials and methods. Experimental studies were carried out by testing reinforced concrete elements under an eccentrically applied static compressive load, taken into account the requirements of the current regulations. Results. The result of the studies involve experimental data on the normal section strength of eccentrically compressed reinforced concrete elements with various options of loop reinforcement joints, as well as data on their stiffness and crack resistance.Conclusion. According to the results of experimental studies, destructive loads, cracking patterns, and deflections of test samples were determined. For all eccentrically compressed samples with loop joints, the strength of normal sections is lower by 3–12 % than the strength of control samples without reinforcement joints. This reveals a tendency of a bearing capacity to increase as the length of the straight insert at the joint, as well as the area of the transverse reinforcement in the joint area, increases. Further, a more detailed publication of the obtained experimental data is planned.
Fire resistance and fire hazard study of combined metal-timber structures
Authors: Komarova M. A. , Grishin I. A. , Shalabin M. V. , Strekalev A. N. , Melnikov N. O. 
Published: December 2023

Introduction. Due to the increasing popularity of timber housing construction, new timber structures with unstudied properties appear provided with no fire safety standards of their use.Aim: to obtain data on fire resistance and fire hazard of combined metal-timber structures, used in floors of residential and public buildings.Materials and methods. In the study, a fragment of a combined metal-timber floor structure with a size of 4300 × 2000 mm and a thickness of 160 mm was tested using the methods for determining fire resistance and fire hazard classes.Results. According to the test results, uncoated samples under a vertical uniformly distributed load of 520 kg/m2 were classified as REI 60, while the Evrika fire retardant, applied to samples from the outside at a consumption of 500 g/m2, has improved their fire resistance to REI 90. The fire hazard class of uncoated samples and coated with fire retardants corresponds to K3(15) and K0(15), respectively.Conclusion. New experimental data will be used in the preparation of amendments to SP 64.13330.2017 “SNiP II-25-80 Timber Structures” for ensuring regulatory fire safety requirements to these structures.
Effects of sample dimensions in compressive strength tests of masonry wall products
Authors: Ponomarev O. I. , Panchenko Yu. F. , Mukhin M. A. , Vetkov A. S. , Dozorova A. Yu. 
Published: December 2023

Introduction. State standards for testing ceramic masonry wall materials of plastic molding establish grinding as the main method of smoothening supporting (loaded) surfaces. Therefore, studies were conducted on the effect of sample dimensions on the compressive strength of tested masonry products. The effect of a scale factor on the measured strength of brick and stone has so far been only partially reflected in the standard for test methods (GOST 8462 “Wall materials. Methods for determining compressive and bending strength”). According to both Russian and foreign specialists, shape factors values, provided in EN 772-1 European standard “Methods of test for masonry units. Part 1. Determination of compressive strength” need to be adjusted as they do not take into account the void ratio of masonry products and the sample material type.Aim. To assess the effects, caused by the geometric dimensions of masonry product samples, as well as the void ratio and other characteristics, on compressive strength according to the results of laboratory tests. Materials and methods. As a result of conducted control tests of ceramic and silicate single and thickened bricks with a void ratio of up to 27 %, measured values of product compression strength were compared to determine the value of transition coefficients.Results. The performed studies confirmed the shape coefficients, adopted in EN 772-1, to require an adjustment. Based on the results of studies, conducted in Russia and abroad, conclusions and recommendations were made to take into account the dimensions of tested samples during strength tests.Conclusion. Performed studies and analysis of experimental results have demonstrated that in order to increase the accuracy of determining the strength of test samples, taking into account their shape and void ratio, it is necessary to have several tables with shape factors. Currently, until reliable data about the void ratio effect of the masonry material on test results are obtained, it is advisable to take into account only the height of the sample (“longitudinal bending”).
Difficulties in Assessing the Economic Burden of Alzheimer's Disease
Authors: Arbatskiy M. S. 
Published: December 2023

Background. Age-related changes associated with the decrease in health and autonomy drastically increase the cost of medical care, maintenance and treatment. Late detection of ilnesses is the root cause of escalating the economic weight from age-related diseases, causing a surge in costs for the recovery, treatment and care of those needing outside assistance. One of the age-associated diseases is Alzheimer's disease. Alzheimer's disease is one of the many manifestations of age-related dementia, accompanied by a violation of human cognitive abilities. This cluster of diseases does not affect other systems (cardiovascular, musculoskeletal, digestive), and they can operate normally. An important effect of this disease for society is the impossibility of conducting a full-fledged work activity, as memory, attention, etc. are disturbed. That is, with absolutely normally functioning body systems, a person cannot perform the simplest operations. Another important feature is the lack of an effective way to treat this disease. The pathogenesis is so complex that today there is no method of treatment aimed at all links. Also of great importance is the timeliness of detection of this disease. Due to the fact that recently there were test systems and express diagnostics for the early detection of Alzheimer's disease, it became possible to start treatment earlier, which increased the chances of recovery and reduced treatment costs in case of diagnosing moderate and severe Alzheimer's disease gravity. Aim. Revealing the difficulties of assessing the economic burden of Alzheimer's Disease. Materials and methods. To identify the difficulties of assessing the economic burden, free sources, publications on Alzheimer's disease, data from clinical guidelines, the standard for providing medical care to elderly and senile patients with cognitive disorders, information on maximum selling prices registered and included in the State Register of Vital and Essential Drugs Prices, statistical data, compulsory health insurance tariffs. Results. The main problematic issues of the difficulty of assessing the economic burden of Alzheimer's disease are identified. Conclusion. Diseases of the nervous system are of particular importance for the health of the patient, since disorders affecting this system do not allow the patient to fully and fully fulfill their labor duties. In this regard, the development of a method for assessing the cost-effectiveness of Alzheimer's disease, as one of the most common disorders of cognitive functions, is an extremely important social task aimed at optimizing the treatment process, early detection and effective treatment aimed at recovery.
Adquisición legal de derechos reales sobre cosas inmuebles, por sub-adquiriente, de buena fe y a título oneroso: una hermenéutica sistemática
Authors: Pollini Inaudi Valeria 
Published: December 2023

El presente ensayo tiene por objeto el estudio del supuesto de adquisición legal de derechos reales sobre cosas inmuebles por sub-adquirente a título oneroso y de buena fe, a la luz de una directiva interpretativa sistemática. El punto de partida analítico consistirá en deslindar conceptualmente las dinámicas funcionales subyacentes al supuesto de adquisición legal analizado y al supuesto de adquisición legal por adquirente de buena fe a título oneroso, de cosas muebles no registrables, que no hayan sido hurtadas/robadas o perdidas. A partir de allí, se intentará realizar un abordaje integral del instituto bajo estudio, con el objeto de responder a una serie de interrogantes vinculados al efecto no convalidante del registro inmobiliario, la aplicabilidad del supuesto a la adquisición de derechos reales que se ejerzan o no por la posesión, derechos reales principales y accesorios, como así también la posibilidad de recurrir a modalidades abreviadas del tracto sucesivo. Finalmente, en torno a los supuestos de inecacia de los actos jurídicos a los que el supuesto se aplica.
Abstract
The purpose of this essay is to study the case of legal acquisition of rights in rem over real property by a sub acquirer for valuable consideration and in bona fide, in the light of a systematic interpretative guideline. fe analytical starting point will be to conceptually delineate the functional dynamics underlying the legal acquisition assumption analyzed and the legal acquisition assumption by a bona fide acquirer for valuable consideration, of non-registrable movable things, which have not been stolen or lost. From there, an integral approach of the institute under study will be attempted, with the purpose of answering a series of questions related to the principle of non-validation of the real estate registry, the applicability of the case to the acquisition of rights in rem that are exercised or not by possession, main and accessory rights in rem, as well as the possibility of resorting to abbreviated modalities of the successive tract. Finally, with respect to the cases of inefectiveness of the legal acts to which the assumption applies.
Correlación Colposcopica e Histopatológica en Citologías con Reporte de Células Escamosas Atípicas de Significado Indeterminado (ASCUS) Durante el Periodo 2019 -2020
Authors: López Monterrey Miriam , Cruz Sacramento Ángela Carlota , Nava Garduño Ariana Monserrat 
Published: December 2023

El cáncer cervicouterino es un problema de salud a nivel mundial caracterizado por el crecimiento anormal y diseminado de células, que al desarrollarse en forma incontrolada, avanzan entre los tejidos normales y los destruyen, alterándose así el funcionamiento del organismo, se inicia casi siempre como una enfermedad localizada1, cuarto cáncer más común en mujeres después del cáncer de mama, colon y pulmón mostrando importancia al realizar el tamizaje de las citologías para prevenir el aumento de la mortalidad2. Material y métodos: Es un estudio de índole observacional, retrospectivo, descriptivo, transversal, incluyó a pacientes de 25 a 65 años derivadas de la unidad médica familiar número 64 con reporte de citología de ASCUS que se encuentren en seguimiento en la clínica de Displasias del Hospital General de Zona número 3 y cuenten con reporte de colposcopia e histopatología, del 01 enero 2019 al 31 de diciembre 2020 en donde se utilizó el total del universo de acuerdo a los criterios de inclusión y exclusión. Resultados: Derivado a los diagnósticos presentados entre la colposcopia e histopatología, donde ambos reportaron una lesión de bajo grado mediante la correlación de spearman no se encontraron diferencias estadísticamente significativas con una p>0.05 y una rs=-0.007. Conclusiones: Aunque se observaron tendencias específicas en relación con cada variable estudiada, la mayoría no alcanzó significación estadística, probablemente debido a la baja prevalencia de LEIAG en la muestra analizada. No obstante, el número de gestaciones emergió como un factor significativo, lo que justifica la realización de investigaciones adicionales. Estos hallazgos subrayan la importancia de entender cómo las variables demográficas y clínicas pueden influir en el desarrollo de lesiones escamosas intraepiteliales y, en última instancia, en el riesgo de malignidades.
Impacto de la Utilización de las Redes Sociales en el Crecimiento del Desarrollo del Turismo, Distritos de Isla Umbú, Humaitá y Paso de Patria, Años 2022 – 2023
Authors: Marecos Negrette Gregorio 
Published: December 2023

El turismo, factor significativo en el sector económico a nivel mundial, y en la actualidad con el uso de las redes sociales permiten brindar mayores datos e información con alcance de gran magnitud y en forma masiva a usuarios de todos los rincones del mundo sin discriminación. Desde esta perspectiva, se tiene por objetivo determinar el uso de las redes sociales, por los pobladores, del distrito de Isla Umbú, Humaitá y Paso de Patria, en los años 2022 – 2023; considerando el impacto que tienen estas herramientas para el incremento del turismo en la zona. Se adopta una metodología no experimental de tipo descriptivo, con enfoque mixto, cuali- cuantitativo, de corte transversal a partir de un cuestionario y entrevista, aplicado a una muestra aleatoria simple intencional, compuesta, por 3 intendentes, 3 concejales, 10 referentes comerciales, y a 20 pobladores, teniendo como problemática la relevancia del uso de las tecnologías de información y comunicación como herramientas de potencial acceso y alcance para permitir la difusión y captación de clientes a los destinos turísticos de las zonas geográficas del departamento de Ñeembucú anteriormente mencionadas. La realización de esta investigación, se circunscribe en la necesidad de superar las barreras para el acceso digital, y el aporte de las redes sociales, mediante su buen uso, evidenciándose en la revisión bibliográfica, ahondar en el alcance de los conceptos, identificando los aspectos esenciales del sector económico; concluyendo, que las redes sociales influyen en la economía local, ya que a través de las mismas se pueden publicitar y dar a conocer, los atractivos turísticos de los Distritos, y servicios del comercio local, afirmándose, que el uso de las redes sociales, es fundamental para el desarrollo del turismo, que muchos turistas han tenido la oportunidad de contactar y conocer los Distritos, mediante las redes sociales.
Les clowns, délicatement
Authors: Cornut Nicolas 
Published: December 2023

Dans cet article, l’auteur déplie l’intuition suivante : la délicatesse est absolument nécessaire au clown. Pourquoi ? Comment ? La transposition créative de la situation scénique dans un imaginaire décalé est une opération délicate : ni trop près ni trop loin du réel. La personne qui apparaît en clown met en scène ses enjeux narcissiques fondateurs. Elle donne forme à ses impasses de contact.
Bacillary Layer Detachment as a Presenting Feature of Ocular Sarcoidosis
Authors: Serels Chad M. , Bhatter Param , Srivastava Sunil K. , Lowder Careen Y. , Mammo Danny A. 
Published: December 2023

Background and Objective:
Bacillary layer detachment (BALAD) is a recently described finding on optical coherence tomography (OCT) that has been reported in a variety of uveitic and retinal diseases. To add to the growing literature on conditions associated with this finding, we report on the first cases of BALADs in ocular sarcoidosis.

Patients and Methods:
Observational, retrospective chart review of patients with BALADs as a feature of sarcoid-associated uveitis.

Results:
Three patients presented with blurry vision and bacillary layer detachments on OCT who were either known to have or found to have sarcoid-associated uveitis. All three patients had resolution of the BALAD and improvement in visual acuity with a combination of high-dose oral steroids and/or systemic immunosuppression.

Conclusions:
Patients presenting with BALAD should be assessed for sarcoidosis, if appropriate, given the systemic implications of this diagnosis.

[
Ophthalmic Surg Lasers Imaging Retina
2023;54:686–690.]
Effectiveness of Caregiver Intervention for Improving Medication Adherence on Level of Medication Adherence and Attitude toward Medications among Nonadherent Patients with Mental Illness
Authors: Kaur Simrat , Baby Renju Sussan , Padhy Susanta Kumar 
Published: December 2023

Abstract

Background:
Nonadherence to medication is the major challenge in treating mental illness, resulting in worsening symptoms and prolonging the course of the illness. Caregivers spend a considerable amount of time with the patients. Therefore, proper training and education for caregivers help to improve treatment outcomes.

Aim:
This study aims to evaluate the effectiveness of caregiver intervention for improving medication adherence (CIIMA) on level of medication adherence and attitude toward medications among nonadherent patients with mental illness.

Methods:
This study was an experimental study using a randomized pretest posttest control group design. The study was conducted in the psychiatric outpatient department of tertiary care hospital in the eastern India. Eighty nonadherent patients with mental illness and their primary caregivers were randomly allocated to the experimental and control group using the concealment allocation method. Patients were assessed for their level of medication adherence using medication adherence rating scale, their attitude toward medication were assessed using drug attitude inventory and reasons for medication nonadherence were assessed using the Rating of Medication Influence. CIIMA consisted of individual psycho-education, pill card monitoring, weekly telephonic and text reminders provided to the experimental group, and routine treatment was provided to the control group. The level of medication adherence and attitude toward medication were reassessed for both groups after 1 month of the initial assessment.

Results:
After 1 month of CIIMA, 87.2% of patients in the experimental group were adherent to medication as compared 18.4% in the control group (P < 0.001), significant improvement in their attitude toward medication and treatment in the experimental group as compared to the control group (P = 0.001).

Conclusion:
CIIMA is an effective, low-cost, nurse-led intervention can be delivered in the inpatient and outpatient units for improving medication adherence thereby preventing future relapse of their mental illness.