bluuebunny/crossref_metadata_2025_split huggingface dataset:
To be remembered: B cell memory response against SARS‐CoV‐2 and its variants in vaccinated and unvaccinated individuals
Authors: Ahmed Nafees , Athavale Atharv , Tripathi Ankita H. , Subramaniam Adarsh , Upadhyay Santosh K. , Pandey Anil Kumar , Rai Ramesh Chandra , Awasthi Amit 
Published: December 2023

AbstractCOVID‐19 disease has plagued the world economy and affected the overall well‐being and life of most of the people. Natural infection as well as vaccination leads to the development of an immune response against the pathogen. This involves the production of antibodies, which can neutralize the virus during future challenges. In addition, the development of cellular immune memory with memory B and T cells provides long‐lasting protection. The longevity of the immune response has been a subject of intensive research in this field. The extent of immunity conferred by different forms of vaccination or natural infections remained debatable for long. Hence, understanding the effectiveness of these responses among different groups of people can assist government organizations in making informed policy decisions. In this article, based on the publicly available data, we have reviewed the memory response generated by some of the vaccines against SARS‐CoV‐2 and its variants, particularly B cell memory in different groups of individuals.
Computer vision model for the detection of canine pododermatitis and neoplasia of the paw
Authors: Smith Andrew , Carroll Patrick W. , Aravamuthan Srikanth , Walleser Emil , Lin Haley , Anklam Kelly , Döpfer Dörte , Apostolopoulos Neoklis 
Published: December 2023

AbstractBackgroundArtificial intelligence (AI) has been used successfully in human dermatology. AI utilises convolutional neural networks (CNN) to accomplish tasks such as image classification, object detection and segmentation, facilitating early diagnosis. Computer vision (CV), a field of AI, has shown great results in detecting signs of human skin diseases. Canine paw skin diseases are a common problem in general veterinary practice, and computer vision tools could facilitate the detection and monitoring of disease processes. Currently, no such tool is available in veterinary dermatology.AnimalsDigital images of paws from healthy dogs and paws with pododermatitis or neoplasia were used.ObjectivesWe tested the novel object detection model Pawgnosis, a Tiny YOLOv4 image analysis model deployed on a microcomputer with a camera for the rapid detection of canine pododermatitis and neoplasia.Materials and MethodsThe prediction performance metrics used to evaluate the models included mean average precision (mAP), precision, recall, average precision (AP) for accuracy and frames per second (FPS) for speed.ResultsA large dataset labelled by a single individual (Dataset A) used to train a Tiny YOLOv4 model provided the best results with a mean mAP of 0.95, precision of 0.86, recall of 0.93 and 20 FPS.Conclusions and Clinical RelevanceThis novel object detection model has the potential for application in the field of veterinary dermatology.
Effects of Water-to-Air Mass Ratio on Long-Term Washing Efficiency and Erosion Risk in an Axial Compressor Under Online Washing Conditions
Authors: Agati Giuliano , Venturini Paolo , Gabriele Serena , Rispoli Franco , Borello Domenico 
Published: December 2023

Abstract
One of the main reasons for gas turbines’ performance losses is the deposition of dirt on the compressor blades. Dirt deposit has to be periodically removed to keep the engine performance as high as possible. This is the reason motivating the presence of online water washing systems in most compressor gas turbines. Such systems aim at cleaning the compressor blades to recover efficiency; thus, the larger the water flow, the better it is assumed the compressor is cleaned (fixing all the other conditions). In the present work, we simulate the long-term behavior of a real axial compressor, from the inlet to the first-stage rotor, subject to online water washing with different water flowrates. The frozen rotor approach is adopted to solve the flow field in the rotor region. Simulations are performed by using the unsteady k-ɛ realizable model coupled with a Lagrangian tracking of the injected liquid phase. Water droplet erosion is handled by using a semi-empirical model developed by the authors. In each simulation, 504,000 parcels have been tracked, providing statistically reliable predictions. To simulate the long-term evolution of the washing process, a discrete mesh morphing technique coupled with the use of specific scale factors is adopted. Each of the tested configurations is composed of three successive erosive steps up to the blade compressor end-of-life. By varying the water-to-air mass fraction (WAMF*), six different injection configurations are assessed in terms of long-time average washing efficiency and erosion risk. The results predicted show the dependence of the considered washing indices on water mass flowrate and set the stage for the development of a washing optimization tool, which can help the design and management processes. In scenarios where washing indices are given minimal importance and the objective is to reduce the risk of erosion, the optimal injection configuration was shown to correspond to a WAMF* value of 0.250. Conversely, when washing efficiency is prioritized, the optimal injection configuration has been shown to correspond to the case where WAMF* = 0.750.
Cecal microbiota and mammary gland microRNA signatures are related and modifiable by dietary flaxseed with implications for breast cancer risk
Authors: Wu Diana , Thompson Lilian U. , Comelli Elena M. 
Published: December 2023

ABSTRACT
The gut microbial ecosystem underlies physiological relationships between the gut and distal organs. Mechanisms remain elusive but rely at least partially on the production of a diverse set of absorbable metabolites and host gene expression regulation. Here we show that in female mice, gut cecal microbiota profiles are related to microRNAs (miRNAs) expressed in the mammary gland. A subset of these miRNAs were found to regulate genes involved in breast cancer-related processes, such as cell proliferation and migration. To determine if these relationships could be exploited toward the reduction of breast cancer risk, we studied if they are modifiable by dietary flaxseed (FS), a source of lignan secoisolariciresinol diglucoside (SDG) and alpha-linolenic acid (ALA)-rich oil (FSO), both with antitumor effects. Importantly, SDG, but not ALA, needs microbial processing to release bioactive metabolites. We found that the microbiota and mammary gland miRNA are related, and FS modifies these relationships toward an antioncogenic phenotype. FSO- and SDG-related miRNAs were found to be involved in different pathways and neither FSO nor SDG alone could recapitulate the effects of whole FS, affecting unique pathways related to extracellular matrix processing. These findings highlight the existence of inter-organ microbiota-miRNA relationships, show that dietary interventions interact to affect them, and suggest a novel route for breast cancer prevention.

IMPORTANCE
Breast cancer is a leading cause of cancer mortality worldwide. There is a growing interest in using dietary approaches, including flaxseed (FS) and its oil and lignan components, to mitigate breast cancer risk. Importantly, there is recognition that pubertal processes and lifestyle, including diet, are important for breast health throughout life. Mechanisms remain incompletely understood. Our research uncovers a link between mammary gland miRNA expression and the gut microbiota in young female mice. We found that this relationship is modifiable via a dietary intervention. Using data from The Cancer Genome Atlas, we also show that the expression of miRNAs involved in these relationships is altered in breast cancer in humans. These findings highlight a role for the gut microbiome as a modulator, and thus a target, of interventions aiming at reducing breast cancer risk. They also provide foundational knowledge to explore the effects of early life interventions and mechanisms programming breast health.
Kinetic Assessment of the Biodegradability of Gel-Forming Soil Conditioners in Incubation Experiments with Instrumental Monitoring of Carbon Dioxide
Authors: Smagin A. V. , Sadovnikova N. B. , Belyaeva E. A. , Korchagina K. V. , Kokoreva A. A. , Krivtsova V. N. 
Published: December 2023

Abstract
A quantitative study of the biodegradability of polymer soil conditioners is necessary for a reasonable prediction of their stability and functioning in soils. For this purpose, a new methodological approach based on PASCO (USA) equipment was proposed. This approach allows recording continuous kinetic curves of CO2 emission in laboratory experiments based on incubation of composite gel-forming soil conditioners. Several characteristic types of respiration curves have been identified, and new physically based models have been proposed for their description with subsequent calculation of the half-lives of composite hydrogels. For the traditionally considered non-biodegradable acrylic superabsorbents of soil water, the possibility of rapid biodegradation was shown for the first time in the case of the addition of a biologically active compost extract into their liquid phase. With this treatment, which brings laboratory experiments closer to real soil conditions, the half-lives of both the well-known European Aquasorb and Zeba superabsorbents and the Russian Aquapastus hydrogel decreased by an order of magnitude from the initial values of 2–6 years to 0.1–0.3 years. In practice, this can negatively affect the profitability of using such materials for soil conditioning due to their rapid destruction and loss of functionality. The addition of silver ions into innovative Aquapastus composite superabsorbents at a dose of 0.1% or 10 ppm in swollen gel structures effectively reduces their biodegradability, prolonging the half-life to 10 years or more, which is twice the German standard DüMV 05.12.12 of the stability of polymer ameliorants.
Elemental Phosphorus in the Synthesis of Organophosphorus Compounds: The Recent Advances (A Review)
Authors: Malysheva S. F. , Kuimov V. A. , Arbuzova S. N. 
Published: December 2023

Abstract
Recent publications on direct reactions of elemental phosphorus with organic halides (alkyl bromides, aryl (and hetaryl) halides, and aryl (and hetaryl) methyl halides) in the presence of superbasic and micellar catalysts are considered. The development of effective, technologically and environmentally acceptable methods for obtaining alkyl(and benzyl)-H-phosphinic and alkylphosphonic acids, triaryl(and hetaryl)phosphines and hetarylmethylphosphine oxides based on the above reactions is analyzed.
Non-pharmacological pain relief interventions in preterm neonates undergoing screening for retinopathy of prematurity: a systematic review
Authors: Fajolu Iretiola Bamikeolu , Dedeke Iyabode Olabisi Florence , Ezenwa Beatrice Nkolika , Ezeaka Veronica Chinyere 
Published: December 2023

ObjectiveThe objective of this review was to determine the efficacy of non-pharmacological interventions for pain management during retinopathy of prematurity (ROP) screening.Methods and analysisElectronic search of Ovid MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cumulative Index to Nursing and Allied Health Literature, Google Scholar and ClinicalTrials.gov (USA) was conducted. Search terms from the research question and inclusion criteria were used to select randomised control trials (RCT) published from January 2000 to May 2023. Relevant data were extracted, and risk of bias was assessed using the Cochrane Risk of Bias tool V.2. Critical appraisal and grading of the quality of evidence were done using the Critical Appraisal Skills Programme tool for RCTs and the Grading of Recommendations Assessment, Development and Evaluation, respectively.ResultsTwenty-one RCTs were included; 14 used sweet taste, while 7 used modified developmental care, touch or positioning, multisensory stimulation, non-nutritive sucking or music. Six studies on sweet taste and all seven latter studies showed a difference in the pain scores in favour of the interventions. The quality of evidence was however judged low and moderate due to some concerns in the randomisation process, measurement of outcome assessment and selection of reported results domains.ConclusionThe use of gentle touch, nesting, positioning, music, multisensory stimulation and developmental care in reducing pain during ROP screening is promising, however, larger studies designed to eliminate the identified concerns are needed. More evidence is also needed before sweet taste interventions can be recommended in routine practice.
First law of black hole thermodynamics and the weak cosmic censorship conjecture for Kerr–Newman Taub–NUT black holes
Authors: Yang Si-Jiang , Guo Wen-Di , Wei Shao-Wen , Liu Yu-Xiao 
Published: December 2023

AbstractStimulated by the recent researches of black hole thermodynamics for black hole with Newman–Unti–Tamburino (NUT) parameter, we investigate the thermodynamics and weak cosmic censorship conjecture for a Kerr–Newman Taub–NUT black hole. By defining the electric charge as a Komar integral over the event horizon, we construct a consistent first law of black hole thermodynamics for a Kerr–Newman Taub–NUT black hole through Euclidean action. Having the first law of black hole thermodynamics, we investigate the weak cosmic censorship conjecture for the black hole with a charged test particle and a complex scalar field. We find that an extremal black hole cannot be destroyed by a charged test particle and a complex scalar field. For a near-extremal black hole with small NUT parameter, it can be destroyed by a charged test particle but cannot be destroyed by a complex scalar field.
Genetic and Environmental Causes of Variation in an Automated Breast Cancer Risk Factor Based on Mammographic Textures
Authors: Ye Zhoufeng , Dite Gillian S. , Nguyen Tuong L. , MacInnis Robert J. , Schmidt Daniel F. , Makalic Enes , Al-Qershi Osamah M. , Nguyen-Dumont Tu , Goudey Benjamin , Stone Jennifer , Dowty James G. , Giles Graham G. , Southey Melissa C. , Hopper John L. , Li Shuai 
Published: December 2023

Abstract

Background:
Cirrus is an automated risk predictor for breast cancer that comprises texture-based mammographic features and is mostly independent of mammographic density. We investigated genetic and environmental variance of variation in Cirrus.

Methods:
We measured Cirrus for 3,195 breast cancer–free participants, including 527 pairs of monozygotic (MZ) twins, 271 pairs of dizygotic (DZ) twins, and 1,599 siblings of twins. Multivariate normal models were used to estimate the variance and familial correlations of age-adjusted Cirrus as a function of age. The classic twin model was expanded to allow the shared environment effects to differ by zygosity. The SNP-based heritability was estimated for a subset of 2,356 participants.

Results:
There was no evidence that the variance or familial correlations depended on age. The familial correlations were 0.52 (SE, 0.03) for MZ pairs and 0.16(SE, 0.03) for DZ and non-twin sister pairs combined. Shared environmental factors specific to MZ pairs accounted for 20% of the variance. Additive genetic factors accounted for 32% (SE = 5%) of the variance, consistent with the SNP-based heritability of 36% (SE = 16%).

Conclusion:
Cirrus is substantially familial due to genetic factors and an influence of shared environmental factors that was evident for MZ twin pairs only. The latter could be due to nongenetic factors operating in utero or in early life that are shared by MZ twins.

Impact:
Early-life factors, shared more by MZ pairs than DZ/non-twin sister pairs, could play a role in the variation in Cirrus, consistent with early life being recognized as a critical window of vulnerability to breast carcinogens.
First-Line Ipatasertib, Atezolizumab, and Taxane Triplet for Metastatic Triple-Negative Breast Cancer: Clinical and Biomarker Results
Authors: Schmid Peter , Turner Nicholas C. , Barrios Carlos H. , Isakoff Steven J. , Kim Sung-Bae , Sablin Marie-Paule , Saji Shigehira , Savas Peter , Vidal Gregory A. , Oliveira Mafalda , O'Shaughnessy Joyce , Italiano Antoine , Espinosa Enrique , Boni Valentina , White Shane , Rojas Beatriz , Freitas-Junior Ruffo , Chae Yeesoo , Bondarenko Igor , Lee Jieun , Torres Mattos Cesar , Martinez Rodriguez Jorge Luis , Lam Lisa H. , Jones Surai , Reilly Sarah-Jayne , Huang Xiayu , Shah Kalpit , Dent Rebecca 
Published: December 2023

Abstract

Purpose:
To evaluate a triplet regimen combining immune checkpoint blockade, AKT pathway inhibition, and (nab-) paclitaxel as first-line therapy for locally advanced/metastatic triple-negative breast cancer (mTNBC).

Patients and Methods:
The single-arm CO40151 phase Ib study (NCT03800836), the single-arm signal-seeking cohort of IPATunity130 (NCT03337724), and the randomized phase III IPATunity170 trial (NCT04177108) enrolled patients with previously untreated mTNBC. Triplet therapy comprised intravenous atezolizumab 840 mg (days 1 and 15), oral ipatasertib 400 mg/day (days 1–21), and intravenous paclitaxel 80 mg/m2 (or nab-paclitaxel 100 mg/m2; days 1, 8, and 15) every 28 days. Exploratory translational research aimed to elucidate mechanisms and molecular markers of sensitivity and resistance.

Results:
Among 317 patients treated with the triplet, efficacy ranged across studies as follows: median progression-free survival (PFS) 5.4 to 7.4 months, objective response rate 44% to 63%, median duration of response 5.6 to 11.1 months, and median overall survival 15.7 to 28.3 months. The safety profile was consistent with the known toxicities of each agent. Grade ≥3 adverse events were more frequent with the triplet than with doublets or single-agent paclitaxel. Patients with PFS &gt;10 months were characterized by NF1, CCND3, and PIK3CA alterations and increased immune pathway activity. PFS &lt;5 months was associated with CDKN2A/CDKN2B/MTAP alterations and lower predicted phosphorylated AKT-S473 levels.

Conclusions:
In patients with mTNBC receiving an ipatasertib/atezolizumab/taxane triplet regimen, molecular characteristics may identify those with particularly favorable or unfavorable outcomes, potentially guiding future research efforts.
The rise of responsible metrics as a professional reform movement: A collective action frames account
Authors: Rushforth Alexander , Hammarfelt Björn 
Published: December 2023

Abstract
Recent years have seen a rise in awareness around “responsible metrics” and calls for research assessment reforms internationally. Yet within the field of quantitative science studies and in research policy contexts, concerns about the limitations of evaluative bibliometrics are almost as old as the tools themselves. Given that many of the concerns articulated in recent reform movements go back decades, why has momentum for change grown only in the past 10 years? In this paper, we draw on analytical insights from the sociology of social movements on collective action frames to chart the emergence, development, and expansion of “responsible metrics” as a professional reform movement. Through reviewing important texts that have shaped reform efforts, we argue that hitherto, three framings have underpinned the responsible metrics reform agenda: the metrics skepticism framing, the professional-expert framing, and the reflexivity framing. We suggest that although these three framings have coexisted within the responsible metrics movement to date, cohabitation between these framings may not last indefinitely, especially as the responsible metrics movement extends into wider research assessment reform movements.
Glyptothorax heokheei, a new species of catfish (Teleostei: Sisoridae) from the Brahmaputra River drainage, Arunachal Pradesh, Northeast India
Authors: SINGH PRATIMA , CHOWDHURY BASUDHARA ROY , GURUMAYUM SHANTABALA DEVI , KOSYGIN LAISHRAM 
Published: December 2023

Glyptothorax heokheei, a new species of sisorid catfish is described from the Brahmaputra River drainage in India. It can be distinguished from all congeners, except G. dikrongensis, G. indicus, G. rugimentum and G. obliquimaculatus, in having the unculiferous striae of thoracic adhesive apparatus extending anteriorly onto gular region. Glyptothorax heokheei is distinguished from G. dikrongensis and G. obliquimaculatus in having a slender body at the anus, more serrations on posterior margin of pectoral-fin spine, greater number of branched anal fin rays, and the extremity of dorsoposterior margin of adipose fin uniformly convex (vs. sharply angular). It differs from G. rugimentum in having a chevron-shaped (vs. rhomboidal) thoracic adhesive apparatus, more serrations on posterior margin of pectoral-fin spine, and lacking vertical bars on body. Glyptothorax heokheei differs from G. indicus in having a shorter post-adipose distance, smaller interorbital width, more serrations on posterior margin of pectoral-fin spine and nasal barbel not reaching (vs. reaching) anterior margin of eye. Glyptothorax heokheei is the fifth species of the genus possessing unculiferous ridges of thoracic adhesive apparatus extending anteriorly onto the gular region.
Efficacy of Psychosocial Care Training Programme for the Staff Working in Old Age Homes
Authors: Shivarudraiah Manjunatha , Ammapattian Thirumoorthy , Antony Sojan , VS Binu , Sivakumar Palanimuthu Thangaraju 
Published: December 2023

Background: Training the old-age home staff is essential in raising geriatric mental health care standards in India. Inadequate knowledge on ageing and psychosocial interventions is a significant issue in old-age homes. Old-age home staff must know how to provide individualized psychosocial care and support for older adults. Hence this study aimed to test the feasibility of the psychosocial care training program for the staff working in old-age homes. Methods: A quasi-experimental research design (pre-post without a control group) was used. Forty-two staff members participated. Mary Starke Harper Aging Knowledge Exam (MSHAKE) and structured checklist to measure the staff’s knowledge on ageing, psychosocial interventions, welfare legislations, schemes, and support services were administered before, immediately after, and two months after the program and the self-efficacy checklist was administered immediately and two months after the program, to examine the efficacy of the program. Results: Significant improvement was found in the ageing knowledge and the knowledge of psychosocial intervention and psychosocial care. These improvements continued for two months ( p < .001). Similarly, their self-efficacy in managing such problems was also sustained across two post-measurements ( p = .045). Conclusions: Face-to-face training programs would enhance the knowledge of the old age home staff. This Psychosocial Care Training module can be used for training old age home staff to address various psychosocial needs, concerns and other psychosocial problems of the residents.