bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single‐Cell RNA‐Sequencing Provides Insight into Skeletal Muscle Evolution during the Selection of Muscle Characteristics
Authors: Xu Doudou , Wan Boyang , Qiu Kai , Wang Yubo , Zhang Xin , Jiao Ning , Yan Enfa , Wu Jiangwei , Yu Run , Gao Shuai , Du Min , Liu Chousheng , Li Mingzhou , Fan Guoping , Yin Jingdong 
Published: October 2023

AbstractSkeletal muscle comprises a large, heterogeneous assortment of cell populations that interact to maintain muscle homeostasis, but little is known about the mechanism that controls myogenic development in response to artificial selection. Different pig (Sus scrofa) breeds exhibit distinct muscle phenotypes resulting from domestication and selective breeding. Using unbiased single‐cell transcriptomic sequencing analysis (scRNA‐seq), the impact of artificial selection on cell profiles is investigated in neonatal skeletal muscle of pigs. This work provides panoramic muscle‐resident cell profiles and identifies novel and breed‐specific cells, mapping them on pseudotime trajectories. Artificial selection has elicited significant changes in muscle‐resident cell profiles, while conserving signs of generational environmental challenges. These results suggest that fibro‐adipogenic progenitors serve as a cellular interaction hub and that specific transcription factors identified here may serve as candidate target regulons for the pursuit of a specific muscle phenotype. Furthermore, a cross‐species comparison of humans, mice, and pigs illustrates the conservation and divergence of mammalian muscle ontology. The findings of this study reveal shifts in cellular heterogeneity, novel cell subpopulations, and their interactions that may greatly facilitate the understanding of the mechanism underlying divergent muscle phenotypes arising from artificial selection.
Free Radical‐Mediated Photocyclization of Triphenylphosphindole Oxides for Photoactivated and Self‐Reported Lipid Peroxidation
Authors: Li Jianqing , Zhuang Zeyan , Guo Jingjing , Dong Xiaobin , Gong Junyi , Tang Ben Zhong , Zhao Zujin 
Published: October 2023

AbstractPhotocyclization is demonstrated as a powerful tool for building complicated polycyclic molecules. And efficient photocyclization is competent as an artful strategy to develop photo‐responsive smart materials. Herein, an efficient free radical‐mediated photocyclization for triphenylphosphindole oxide (TPPIO) derivatives to generate tribenzophosphindole oxide (TBPIO) derivatives at ambient condition is reported. The reaction mechanism and substituent effect on photocyclization efficiency are thoroughly investigated. Additionally, photophysical and photochemical properties of TPPIO and TBPIO derivatives are measured for comparison and deeply deciphered by theoretical calculation. TPPIO derivatives own typical aggregation‐induced emission feature but barely generate reactive oxygen species (ROS), while TBPIO derivatives experience aggregation‐caused quenching but show efficient Type I ROS generation capacity. Further, in vitro experiments demonstrate that this photo‐conversion can efficiently occur in situ in living cells to activate photodynamic therapy (PDT) effect to trigger lipid peroxidation with selective fluorescence “light up” in lipid droplet area under continuous irradiation. This work extends the optoelectronically and biologically interesting phosphindole oxide‐containing π‐conjugated systems through an efficient synthetic strategy, provides in‐depth mechanistic descriptions in the aspects of reaction and property, and further presents their great potentials for photoactivated and self‐reported PDT.
Using extracorporeal membrane oxygenation in donations after cardiac death or brain death: A single‐center experience and long‐term outcome
Authors: Hsieh Chia‐En , Hsu Ya‐Lan , Chen Yao‐Li , Liang Hsin‐Rou , Lin Kuo‐Hua , Chen Wen‐Yuan , Wu Hsiu‐Man , Hunang Sin‐Bao , Hung Yu‐Ju 
Published: October 2023

AbstractAimsThe use of extended criteria donors is a routine practice that sometimes involves extracorporeal membrane oxygenation (ECMO) in donations after cardiac death or brain death.MethodsWe performed a retrospective study in a single center from January 2006 to December 2019. The study included 90 deceased donor liver transplants. The patients were divided into three groups: the donation after brain death (DBD) group (n = 58, 64.4%), the DBD with ECMO group (n = 11, 12.2%) and the donation after cardiac death (DCD) with ECMO group (n = 21, 23.3%).ResultsThere were no significant differences between the DBD with ECMO group and the DBD group. When comparing the DCD with ECMO group and the DBD group, there were statistically significant differences for total warm ischemia time (p < 0.001), total cold ischemia time (p = 0.023), and split liver transplantation (p < 0.001), and there was significantly poor recovery in regard to total bilirubin level (p = 0.027) for the DCD with ECMO group by repeated measures ANOVA. The 5‐year survival rates of the DBD, DBD with ECMO, and DCD with ECMO groups were 78.1%, 90.9%, and 75.6%, respectively. The survival rate was not significantly different when comparing the DBD group to either the DBD with ECMO group (p = 0.435) or the DCD with ECMO group (p = 0.310).ConclusionsUsing ECMO in donations after cardiac death or brain death is a good technology, and it contributed to 35.6% of the liver graft pool.
Endoscopic‐pathological characteristics of early‐onset gastric carcinoma in Vietnamese in the period 2014–2019: A single‐center experience
Authors: Tran Lan Thi‐Ngoc , Quach Duc Trong , Tran Truc Le‐Thanh , Tran Vy Ly‐Thao , Le Huy Minh , Le Nhan Quang , Hiyama Toru 
Published: October 2023

AbstractTo investigate the time‐trend and endoscopic‐pathological characteristics of early‐onset gastric carcinoma (EOGC) in Vietnamese patients. All patients who underwent upper gastrointestinal endoscopy at a tertiary hospital during the 2014–2019 period and had pathologically confirmed gastric carcinoma were retrospectively recruited. The demographic data and endoscopic and pathological findings from all patients were recorded and analyzed to compare the EOGC group (i.e., ≤40 years of age) with the older group (>40 years of age). Out of 1668 patients with gastric carcinoma, 151 (9.1%) patients were with EOGC. The time‐trend change in the EOGC rate was insignificant during the investigated period (p = .972). The median age of patients with EOGC was 35 (IQR, 32–38). Compared with the older group, EOGC was more likely to present with a female predominance (52.3% vs. 30.7%, p < .001), endoscopically located at the gastric body (34.4% vs. 19.2%, p < .001), presented with a diffuse infiltrative appearance (18.9% vs. 11.7%, p = .011) but were less likely to have superficial gastric cancer morphology (0.0% vs. 4.5%, p = .009). Pathologically, it was more likely to have diffuse type (36.4% vs. 23.9%, p = .001) and poor differentiation (90.6% vs. 62.7%, p < .001). EOGC in Vietnamese individuals is not rare, and its incidence has not significantly changed during the studying period. The majority of EOGC was poorly differentiated carcinoma. This study reported the different endoscopic distribution and appearance of EOGC from gastric carcinoma in older patients requiring attention during endoscopic examination.
Transition‐Metal‐Free Synthesis of Alkynylphosphine Oxides from Terminal Alkynes and Chlorodiphenylphosphine Oxide
Authors: Chen Jianyang , Yun Hui , Fu Hongmei , He Huamei , Duan Shicheng , Li Mingyang 
Published: October 2023

AbstractAn efficient, LiN(SiMe3)2‐mediated phosphorylation of terminal alkynes with chlorodiphenylphosphine oxide has been developed to synthesize alkynylphosphine oxides. This transition‐metal‐free protocol was featured with simple operation, mild reaction conditions, and broad substrate scope. The tolerance of halogen and ester substituents displayed the advantages of this new method over the traditional ones. In addition, the application potential was demonstrated by the gram‐scale reaction. When using diisopropyl chlorophosphate and chlorodiphenylphosphine, the corresponding alkynylphosphate and alkynylphosphine could also been produced.
Anisotropic strain sensors to realize skin‐comparable performances
Authors: Wang Wentang , Deng Xinyue , Luo Chunhui 
Published: October 2023

AbstractConductive hydrogels (CHs) are promising candidates for wearable devices. However, it remains challenging for traditional CHs to realize a combination of self‐adhesive and skin‐comparable performances. Herein, a stretch‐induced orientation strategy was demonstrated to achieve this goal. The hydrogel was fabricated from poly(vinyl alcohol), aluminum sulfate, tannin acid, and deionized water, which exhibited skin‐comparable elastic modulus (26.3 kPa), stretchability (180%), and water content (87.6%). Meanwhile, it had anisotropic properties. For instance, the mechanical and anisotropy ratios between parallel and orthogonal directions were 1.77 and 2.02, respectively. Furthermore, the presence of free ions within regular conductive channels imparted stable conductivity (gauge factor of 2.2 within 200% strains), fast response (0.2 s), and low detect limit (a strain of 0.2%). Additionally, the existence of catechol groups from tannin acid enabled self‐adhesion ability (adhesion strength of 73.9 kPa). All of these merits show promising potential in wearable devices and electronic skins.
New results on finite‐time stability and H∞control for nonlinear Hamiltonian systems
Authors: Chen Yufei , Liu Qihuai , Zhou Xia 
Published: October 2023

AbstractIn this paper, we investigate the finite‐time stability (FTS) and control of nonlinear Hamiltonian systems with time‐varying state delays and output delays subject to input saturation. By introducing a new class of Lyapunov–Krasovskii (L‐K) functionals and the assumption about the Hamiltonian function, we present a delay‐dependent FTS criterion. Then, a finite‐time feedback control is designed for the nonlinear Hamiltonian systems. Finally, the validity of the proposed results is demonstrated by a numerical example.
Fluorinated Carbonate‐aided Ionic‐liquid Electrolyte Enables High‐capacity Lithium‐metal Batteries
Authors: Liu Pengfei , Rao Yuxin , Wang Huasong , Li Xue , Wang Xiaomin , Yu Miaomiao , Li Yong , Yue Zhihao , Wu Fanglin , Fang Shan 
Published: October 2023

AbstractIonic liquids (ILs) are promising electrolyte candidates for high‐safety and stability lithium metal batteries. However, their practical application is hindered by high viscosity resulting in a poor wettability of separator and sluggish Li+ transport at room temperature. Herein, a weakly‐solvating solvent of methyl (2,2,2‐trifluoroethyl) carbonate (FEMC) is employed as a co‐solvent in non‐flammable ionic‐liquid electrolyte (ILE) which composed with N‐butyl‐N‐methylpyrrolidinium bis (fluorsulfonyl) imide (Pyr14FSI) and bis (trifluoromethanesulfonyl) sulfonimide lithium salt (LiTFSI), effectively ameliorates the shortcomings of ILs mentioned above without sacrificing its safety character. Compared with pure ILE, the addition of FEMC can distinctly decrease the polarization voltage and electrode‐electrolyte interface resistance. With the assistance of FEMC solvent, the discharge specific capacity of Li||LiFePO4 (LFP) and Li||LiNi0.6Co0.2Mn0.2O2 (NCM622) cells are significantly improved. The origin of this great improvement is contributed to the exceptionally stable and LiF‐rich cathode electrolyte interphase (CEI) layer formed in this electrolyte. Additionally, Li||LiNi0.8Co0.1Mn0.1O2 (NCM811) cells exhibit a remarkable rate capability (105 mAh g−1 at 2 C rate), achieve an initial specific capacity of 202.8 mAh g−1 and outstanding capacity retention of 88.2 % over 100 cycles.
Schnellbauweise für Brücken mit weitgespannten Fertigteilträgern aus C80/95
Authors: Heinrich Jens , Maurer Reinhard , Reddemann Theo , Schnetgöke Till , Yavuz Tamer 
Published: October 2023

AbstractSchnelles Bauen mit möglichst geringen Verkehrsbehinderungen in Verbindung mit einer Minimierung staubedingter CO2‐Emissionen stellt heute im Zeichen des nachhaltigen Bauens und Klimaschutzes ein neues Entwurfsziel für Betonbrücken dar. Im nachfolgenden Beitrag wird über das Potenzial des vorgespannten hochfesten Betons C80/95 für Fertigteilträger bei einem Überführungsbauwerk über eine sechsspurige Autobahn ohne die Notwendigkeit einer Zwischenstütze in Kombination mit dem Einsatz von Fertigteilen auch bei den Widerlagern als Pilotprojekt berichtet. Der Beitrag schließt mit dem bemerkenswerten Ergebnis einer Studie, wie viel CO2‐Emissionen durch die Verkürzung der Bauzeit bei derartigen Bauwerken potenziell vermieden werden können.
Carbon Dots from Tire Waste for the Photodegradation of Methyl Orange Dye, Antimicrobial Activity, and Molecular Docking Study
Authors: Mohammad Nian N. 
Published: October 2023

AbstractIn this study, solvothermal pathway was employed for the synthesis of P, N codoped C‐dot using tire waste as a sustainable source of carbon and nitrogen. Comprehensive analyses encompassing X‐ray diffraction (XRD) analysis, Transmission Electron Microscopy (TEM), FT‐IR, cyclic voltammetry, and UV‐Vis spectra were used to assess the crystalline structure, purity, size, fluorescence up‐conversion, and morphological attributes of the nanomaterial. Subsequently, the produced C‐dots were evaluated for their efficacy in the photocatalytic degradation of methylene blue and methyl orange dyes, demonstrating notable success in degrading methyl orange dye within eight hours in the visible region. Furthermore, the same nanomaterial was applied for carrying out agar disk‐diffusion assays against a spectrum of microorganisms. Results revealed substantial inhibition zones against Methicillin‐Resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa. Elucidating the antimicrobial mechanism, molecular‐docking simulations were excuted using on AutoDock Vina with designated ligands. The results indicated a strong binding affinity of the C‐dots with certain proteins associated with antibacterial activity. This observation suggests that the synthesized C‐dots effectively engage with the active sites of these proteins, indicating their potential as promising antibacterial agents. Importantly, this study implies that C‐dots do not induce protein denaturation, thereby warranting further investigation of their utility as antibacterial agents.
Transcatheter aortic valve implantation in patients with anomalous origin of a coronary artery
Authors: Loria Johannes Rotta detto , Abdelhafez Ahmed , Desch Steffen , Thiele Holger , Abdel‐Wahab Mohamed 
Published: October 2023

AbstractTranscatheter aortic valve implantation (TAVI) has become a well‐established treatment option for elderly patients with symptomatic severe aortic stenosis. Coronary artery anomalies are an infrequent finding and there have only been few anecdotal reports of patients with coronary anomalies treated with TAVI. We here present a comprehensive overview of existing reports in addition to an own case series to facilitate better understanding of this potentially challenging clinical scenario.
Proportional troponin changes and risk for outcomes with intervention strategies in non‐ST‐elevation acute coronary syndrome across kidney function
Authors: Mathew Roy O. , Rangaswami Janani , Abramov Dmitry , Mahalwar Gauranga , Vellanki Shaitalya , Abuazzam Farah , Fraser Gary E. , Butler Fayth Miles , Lo Kevin Bryan , Herzog Charles A. , Shroff Gautam R. , Sidhu Mandeep S. , Bangalore Sripal 
Published: October 2023

AbstractAimsThis analysis evaluates whether proportional serial cardiac troponin (cTn) change predicts benefit from an early versus delayed invasive, or conservative treatment strategies across kidney function in non‐ST‐elevation acute coronary syndrome (NSTE‐ACS).MethodsPatients diagnosed with NSTE‐ACS in the Veterans Health Administration between 1999 and 2022 were categorized into terciles (<20%, 20 to ≤80%, >80%) of proportional change in serial cTn. Primary outcome included mortality or rehospitalization for myocardial infarction at 6 and 12 months, in survivors of index admission. Adjusted hazard ratio (HR) with 95% confidence Intervals (95% confidence interval [CI]) were calculated for the primary outcome for an early invasive (≤24 h of the index admission), delayed invasive (>24 h of index admission to 90‐days postdischarge), or a conservative management.ResultsChronic kidney disease (CKD) was more prevalent (45.3%) in the lowest versus 42.2% and 43% in middle and highest terciles, respectively (p < 0.001). Primary outcome is more likely for conservative versus early invasive strategy at 6 (HR: 1.44, 95% CI: 1.37–1.50) and 12 months (HR: 1.44, 95% CI: 1.39–1.50). A >80% proportional change demonstrated HR (95% CI): 0.90 (0.83–0.97) and 0.93 (0.88–1.00; p = 0.041) for primary outcome at 6 and 12 months, respectively, when an early versus delayed invasive strategy was used, across CKD stages.ConclusionsOverall, the invasive strategy was safe and associated with improved outcomes across kidney function in NSTE‐ACS. Additionally, >80% proportional change in serial troponin in NSTE‐ACS is associated with benefit from an early versus a delayed invasive strategy regardless of kidney function. These findings deserve confirmation in randomized controlled trials.
Exploring indicators of success in chronic total occlusion percutaneous coronary intervention with Stingray system‐based antegrade dissection re‐entry: Insights from retrospective analysis
Authors: Lu Hao , Hu Yiqing , Ma Yuanji , Zhou You , Yao Kang , Ma Jianying , Huang Dong , Ge Lei , Qian Juying , Ge Junbo 
Published: October 2023

AbstractBackgroundThe predictors of success of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) through antegrade dissection and re‐entry (ADR) using the Stingray system (Stingray ADR) remain elusive, mainly owing to the lack of consecutive angiographic and procedural records of patients.ObjectivesThis study aimed to identify indicators that can determine the success of CTO PCI performed using the Stingray ADR technique.MethodsThe clinical data of 115 patients who underwent CTO PCI through Stingray ADR at the same cardiac center were retrospectively and consecutively collected. Multivariate logistic regression analysis was performed to investigate the indicators of the success of ADR attempts.ResultsThe technical success rate of Stingray ADR in CTO PCI was 72.2%. The overall technical success rate of CTO recanalization was 78.3% in all CTO PCIs having used Stingray Low Profile balloon. Vessel calcification (odds ratio [OR]: 4.03; 95% confidence interval [CI]: 1.49−11.88; p = 0.008), and retrograde puncture indicator (OR: 4.89; 95% CI: 1.51−17.11; p = 0.009) were identified as independent positive predictors. Blunt/no stump proximal to the occlusion segment (OR: 0.22; 95% CI: 0.06−0.64; p = 0.009), decision time before Stingray ADR (per 1 h increase) (OR: 0.54; 95% CI: 0.31−0.92; p = 0.026), operation duration of Stingray ADR (per 10 min increase) (OR: 0.62; 95% CI: 0.40−0.94; p = 0.028), and puncture site at the intraplaque region (OR: 0.24; 95% CI: 0.06−0.84; p = 0.026) were identified as the four negative independent predictors.ConclusionsThis study revealed independent predictors of the success of CTO PCI performed using the Stingray ADR technique. As for CTO characteristics, the presence of calcification in the CTO segment and a tapered stump proximal to the lesion site can facilitate successful Stingray ADR. As for the procedures, the success rate of Stingray ADR can be improved by initiating the technique decisively and promptly, operating the system quickly and accurately and creating a puncture in the distal cap region of CTO under retrograde guidance.
Stroke prevention in TAVR: A patient‐tailored approach may be needed
Authors: Willemen Yannick , De Backer Ole 
Published: October 2023

Key PointsThe study by Gorla et al. confirms that the incidence of clinically overt stroke is low in contemporary, real‐world transcatheter aortic valve replacement (TAVR) practice.Patients at increased risk for TAVR‐related stroke may be identified based on baseline risk factors.Randomized trials in selected TAVR patients at increased risk for stroke should evaluate patient‐tailored preventive measures.
Sex‐based differences in left ventricular assist device clinical outcomes
Authors: Imburgio Steven , Dandu Sowmya , Pannu Viraaj , Udongwo Ndausung , Johal Anmol , Hossain Mohammad , Patel Palak , Sealove Brett , Almendral Jesus , Heaton Joseph 
Published: October 2023

AbstractBackgroundHeart failure (HF) continues to be a significant public health issue, posing a heightened risk of morbidity and mortality for both genders. Despite the widespread use of left ventricular assist device (LVAD), the influence of gender differences on clinical outcomes following implantation remains unclear.ObjectivesWe investigated the impact of gender differences on readmission rates and other outcomes following LVAD implantation in patients admitted with advanced HF.MethodsWe conducted a retrospective study of patients who underwent LVAD implantation for advanced HF between 2014 and 2020, using the Nationwide Readmissions Database. Our study cohort was divided into male and female patients. The primary outcome was 30‐day readmission (30‐dr), while secondary outcomes were inpatient mortality, length of stay (LOS), procedural complication rates, and periadmission rates. Multivariate linear, Cox, and logistic regression analyses were performed.ResultsDuring the study period, 11,492 patients with advanced HF who had LVAD placement were identified. Of these, 22% (n = 2532) were females and 78% (n = 8960) were males. The mean age was 53.9 ± 10.8 years for females and 56.3 ± 10.5 years for males (adjusted Wald test, p < 0.01). Readmissions were higher in females (21% vs. 17%, p = 0.02) when compared to males. Cox regression analysis showed higher readmission events (hazard ratio: 1.24, 95% confidence interval: 1.01–1.52, p = 0.03) in females when compared to males. Inpatient mortality, LOS, and most procedural complication rates were not statistically significantly different between the two groups (p > 0.05, all).ConclusionWomen experienced higher readmission rates and were more likely to be readmitted multiple times after LVAD implantation when compared to their male counterparts. However, there were no significant sex‐based differences in inpatient mortality, LOS, and nearly all procedural complication rates. These findings suggest that female patients may require closer monitoring and targeted interventions to reduce readmission rates.
One‐Pot Manganese (I)‐Catalyzed Oxidant‐Controlled Divergent Functionalization of 2‐Arylindazoles
Authors: Kanta Das Krishna , Kumar Ghosh Asim , Hajra Alakananda 
Published: October 2023

AbstractThe oxidant‐controlled divergent synthesis of C‐2′ formyl 2H‐indazoles and indazoloindazolediones has been developed through Mn(I)‐ catalyzed ortho C−H functionalization of 2H‐indazoles with para‐formaldehyde to afford C‐2′ hydroxymethylated 2H‐indazoles and subsequently oxidation with varying the amount of DDQ in one‐pot. By employing selectfluor as the oxidant instead of DDQ, this reaction exclusively provided indazolebenzoxazine derivatives. This strategy delivered unsymmetrical indazoloindazoledione and indazolobenzoxazine with varied functional group tolerance in moderate to good yields.