bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploratory Analysis of the Variable Response to an Intensive Lifestyle Change Program for Metabolic Syndrome
Authors: Maitland Scott B. , Brauer Paula , Mutch David M. , Royall Dawna , Klein Doug , Tremblay Angelo , Rheaume Caroline , Jeejeebhoy Khursheed 
Published: November 2023

Abstract

Background
Wide variability in response to lifestyle interventions has been recognized for many years, and researchers have begun to disentangle sources of error from inherent differences in individual responsiveness. The objective of this secondary analysis of an intensive lifestyle intervention (diet and exercise) for metabolic syndrome (MetS) was to identify potentially important differences among study completers grouped by treatment response as measured by change in a continuous metabolic syndrome (Gurka/MetS) score.
Methods
All study completers from a 12-month primary care study were categorized into one of five groups according to change in the Gurka/MetS score. A change of 0.4 in z-score defined clinically relevant change in line with results of previous studies. Repeated measures analysis of covariance was used to examine the Gurka/MetS score over 12 months, looking for differences in response over time by the five groups.
Results
Of 176 participants, 50% (n = 88) had stable scores, 10% (n = 18) had relevant change scores in the first 3 months only and reverted toward baseline, 20% (n = 35) achieved meaningful change over the whole study, 11% (n = 20) had a delayed response at 3–12 months, and 9% (n = 15) demonstrated worsening scores. Significant response group*time differences were noted (p < 0.001). Improvement in diet quality and fitness scores were similar across all groups. Available other variables did not account for the differences.
Conclusion
Work is needed to identify key factors that account for differences in responses to lifestyle interventions that can be used to guide treatment decisions for intensive lifestyle interventions for this common condition.
Trial Registration
ClinicalTrials.gov Identifier: NCT01616563; first registered June 12, 2012.
Quantum nature of ionic surfactant micelles – alternative view on micellization process
Authors: Zuev Yuriy , Zueva Olga 
Published: November 2023

Abstract

We developed an alternative model of ionic surfactant micellization, in which self-assembly processes have been analyzed qualitatively from point of view different from the classical one using quantum mechanics principles, symmetry considerations, together with theory of self-organization in nonequilibrium systems, accounting the probabilistic nature of processes at nanoscale and their potential quantum coherence. As a result, we declare that micelle is organized as layered fullerene-like structure with a cavity in micelle center, having solid-like properties in radial direction and liquid-like in perpendicular ones and permitting water penetration between head and upper methylene groups of surfactant ions. It was indicated that there is the exchange interaction inside micelle, which leads to socialization of electrons and their transition to the state of quantum coherence. It has been found that indispensable condition for existence of spherical micelles is synchronous radial oscillations of atoms ("breathing" of micellar particle) generating coherent elastic waves and oscillations of coherent electrons, which can be a source of electromagnetic waves with frequencies close to thermal vibration frequencies of atoms. It was shown that long-range correlations connected with radiation and leading to permanently ongoing surfactant self-assembly and disintegration makes micellar solution kinetically nonequilibrium at nanoscale and thermodynamically stable at macroscale.
Decoding Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Journey Through Unilateral Cystic Pulmonary Manifestations—A Rare Case and Literature Review
Authors: Li Ping , Huang Zhisheng , Qin Yan , Liao Wenjiao , Xiang Tianxin 
Published: November 2023

Abstract

We presented an atypical case of a 62-year-old female diagnosed with pulmonary Mucosa-Associated Lymphoid Tissue (p-MALT) lymphoma, uniquely manifesting as a singular cystic lesion in the lung. Diagnostic evaluations, including comprehensive imaging, bronchoscopy, and CT-guided lung biopsy, revealed this uncommon radiological presentation. Detailed histopathological and immunohistochemical assessments further cemented the diagnosis. To determine the disease's extent, systemic evaluations such as whole-body PET-CT, gastroscopy, colonoscopy, and bone marrow biopsy were conducted, confirming its localized nature. Following the definitive diagnosis, the patient underwent a Rituximab-centric therapeutic regimen, yielding significant clinical improvement. This case accentuates the importance of recognizing distinctive cystic lung features in p-MALT lymphoma and the indispensable role of holistic diagnostic approaches in guiding precise therapeutic and prognostic decisions.
Hydrographic climatology of the South Brazil Bight continental shelf and slope
Authors: Sasaki Dalton Kei , Silva Danilo , Del-Giovannino Sergio Rafael , Dottori Marcelo , Silvera Ilso Carlos Almeida da , Belo Wellington Ceccopieri , martins Renato Parkinson 
Published: November 2023

Abstract

A regional climatology of the subtropical area along the South Brazil Bight is created in order to establish the seasonal average hydrographic conditions over the continental shelf and slope. A multiscale objective analysis with a potential vorticity constraint is used with historical hydrographic temperature and salinity profiles from different databases. Relative the World Ocean Atlas 2018, the interpolation produced improved results, which were evaluated by comparing the surface fields with satellite data, and also with sea surface elevation simulated with the Regional Ocean Model System (ROMS). ROMS '3D currents showed that the temperature and salinity fields support the presence of both Brazil Current and its seasonal variability, the Intermediate Western Boundary current, along with recurrent features such as the Cape Frio (cyclonic) Eddy, and remotely generated Agulhas (anticyclonic) Rings. Cape Frio Eddy structure favours the onshore transport of the South Atlantic Central Water (SACW) in the bottom layer along the northeastern area (23 $^\circ$ S) of the shelf break. On the continental shelf, features such as the seasonal uplifting of SACW and the mid-depth intrusions of Tropical Water beneath the Coastal Water (CW) are correctly described. CW can be subdivided into a spicy (austral summer/autumn) and minty (austral winter/spring) subgroups, with the second being influenced by the Subtropical Shelf Water coming from the continental shelf along Argentina and Uruguay, where Rio de La Plata is diluted in the shelf waters.
Factors Associated with Gaps in Naloxone Knowledge: Evidence from a 2022 Great Plains Survey
Authors: Cooper-Ohm Spencer , Habecker Patrick , Humeniuk Ryan , Bevins Rick A. 
Published: November 2023

Abstract
Background
The rising prevalence of fast-acting opioids in the United States suggests the increased need for non-first responder administration of naloxone. Effective administration of naloxone during an overdose requires that bystanders are familiar with, have access to, and know how to use naloxone.
Methods
Drawing on the 2022 Nebraska Annual Social Indicators survey, we analyzed naloxone familiarity, access, and competency to administer among a statewide, address-based sample of Nebraskan adults.
Results
There were significant gaps in naloxone knowledge in Nebraska. Although 75.6% of respondents were familiar with naloxone, only 18.6% knew how to access naloxone and 17.6% knew how to use naloxone. We find that more frequent religious service attendance is associated with lower odds of naloxone familiarity. Among those familiar with naloxone, a higher perception of community stigma towards opioids generally is associated with lower odds of naloxone access and competency. Higher perception of community stigma towards heroin, methamphetamines, and cocaine, however, is associated with higher odds of naloxone access. Finally, past overdose experience, lifetime illicit opioid use, being close to a person who uses opioids, and having access to illicit opioids was not significantly associated with naloxone familiarity, access, or competency among respondents in Nebraska’s two largest cities, Omaha and Lincoln. Outside of these cities, past overdose experience and access to illicit opioids was associated with higher odds of naloxone access and competency, but lifetime opioid use and being close to a person who uses opioids had no effect.
Conclusions
Our findings highlight the continued need for education on naloxone with a specific focus on access and competency to further reduce opioid-related overdose deaths. Education campaigns targeted at places of worship or individuals close to people who use opioids may further serve those with a lower likelihood of naloxone familiarity and promote knowledge of naloxone among those with higher odds of encountering an overdose. Further work is needed to understand differences in the relationship between substance-specific perceived stigma and its association with naloxone access.
Retinopathy of prematurity risk predictors in peripheral avascular retina after intravitreal ranibizumab treatment: Vasculogenesis analysis Running Title: Predictors for Retinopathy Recurrence Post-Ranibizumab
Authors: Chen Jin-Guo , Xiong Li-Chun , Ruan Guan-Yu , Hu Jian-Zhang 
Published: November 2023

Abstract

The predictors of risk for peripheral avascular areas (PAR) in retinopathy of prematurity (ROP) after intravitreal ranibizumab (IVR) monotherapy is still unknown.
This retrospective study included 64 infants (118 eyes) who developed type 1 ROP and received IVR between July 2019 and March 2021. Retinal vascular outgrowth speed (RVOS) was assessed by measuring the disc diameter (DD) 2 months post-IVR. Potential risk factors were identified to develop a predictive nomogram model for PAR. Decision curve analysis (DCA) was performed to determine the clinical utility of the nomogram model. Mean RVOS was 0.9±0.6 DD/month in all eyes 2 months post-IVR; RVOS in the treated eyes was higher than that in the non-treated eyes. Completed retinal vascularization was detected in 69 eyes (58.5%) and persistent PAR in 49 eyes (41.5%). Multiple logistic regression analysis showed that postnatal age (PNA) at IVR, ROP lesion’s cumulative clock hours (ROP_CCH), RVOS after IVR, and lesion severity were independent risk factors for PAR. DCA showed the nomogram model provides a fine net benefit. These data showed that IVR treatment accelerates RVOS. Further, RVOS is inversely related to PAR. The proposed nomogram model can potentially be effective in the individualized prediction of PAR after IVR.
Use of water quality index and DRASTIC index correlation for better assessment of groundwater vulnerability to pollution: a case study
Authors: Chaudhary Jatin , Singh K. K. 
Published: November 2023

Abstract

DRASTIC method's vulnerability assessment for estimating the potential risk of contamination in shallow groundwater aquifers is the most acceptable technique. The method uses seven parameters, namely, depth to groundwater table, net recharge, aquifer media, soil media, topography, land use and land cover, and hydraulic conductivity to obtain vulnerability index values. These index values are validated with one or a few elements of water characteristics as pollution indicators. In most of the reported studies, the correlation coefficient between the DRASTIC index and the concentration of individual element(s) was low. The present study uses the water quality index (WQI) to correlate with the DRASTIC index value. In this paper, 11 physical and chemical water characteristics data of 31 well locations within the Faridabad District of Haryana, India are utilized to estimate the WQI. The correlation coefficients for single element concentration with DRASTIC index vary between the range of 0.104 to 0.304. The correlation coefficients for the concentration of NO3- and WQI are found to be 0.104 and 0.533, respectively. Thus, the DRASTIC index demonstrates a stronger correlation with the WQI when compared to single element concentration.
Aggression Mediates Relationships between Social Media Addiction and Adolescents’ Wellbeing
Authors: Rustamov Elnur , Aliyeva Matanat , Rustamova Narinj , Nuriyeva Ulkar Zalova , Nahmatova Ulviyya 
Published: November 2023

Background:
Digital technologies have an important role in human behavior and well-being.

Aim:
The study aimed to investigate the mediation role of aggression in the relationship between social media addiction and mental well-being.

Methods:
The study participants comprised 1354 adolescents, of whom 808 were female and 546 were male. The mean age of the participants was 14.12 (SD= 1.51). Data were gathered via the Bergen Social Media Addiction Scale, Buss Perry Aggression Questionnaire, and Warwick-Edinburgh Mental Wellbeing Scale.

Results and Discussion:
The results of the study demonstrated aggression to partially mediate the relationship between social media addiction and mental well-being. Hence, it can be said that social media addiction negatively predicts mental well-being through aggression.

Conclusion:
As a result, mental health professionals should take into account the role of social media addiction and aggression when they work with adolescents who need help to improve their mental well-being.
Intimate Partner Violence among Married Couples in India: A Systematic Review
Authors: Shikhila T. , Kanth Barani 
Published: November 2023

Introduction:
Intimate partner violence (IPV) among married couples is an area of concern in the current scenario in India. It is an important public health issue that substantially affects a person’s mental and physical health. Thus, in this systematic review, we aim to review and analyze the previous literature on the antecedents, consequences, and intervention studies on IPV conducted in India.

Methods:
We conducted a literature search on the following network databases: APA PsycNet, Google Scholar, and ScienceDirect. We selected 47 studies potentially relevant articles published from 2000 to 2023 for detailed evaluation. The systematic review was done adhering to PRISMA guidelines.

Results:
Our results indicated that very few studies are conducted in the Indian cultural context that explored the issues of IPV. There are various demographic, cultural, and individual factors acting as risk factors for perpetrating IPV in India. Studies also show a significant impact of IPV on mental and physical health. Additionally, very few interventional studies have been conducted to prevent or reduce IPV in India. From the study results, we can infer that there is a need to adapt or develop indigenous interventions for IPV in India.

Conclusion:
Considering the aspects discussed in the present study, we understood that IPV is a major, widely prevalent, under-recognized issue in India. So, the study implies a necessity for conducting more research in the Indian cultural context and developing indigenous intervention studies in India.
Environmental Exposures, Characteristics, and Treatment Outcomes of Hypersensitivity Pneumonitis at a Rural Appalachian Academic Medical Center: A Cross-sectional Study
Authors: Deepak Vishal , Buragamadagu Bhanusowmya , Landis Ty , Salyer Rachel , Balakrishnan Bathmapriya 
Published: November 2023

Purpose:Hypersensitivity pneumonitis (HP) is a form of interstitial lung disease (ILD) caused by inhalational exposure to an antigen. Little is known about the exposures, outcomes, and management of HP in rural Appalachian patients.Methods:A retrospective cross-sectional study was conducted from January 1, 2017, to June 30, 2022, at a tertiary academic medical center. Sixty-two patients were initially screened, and seven patients fulfilled the inclusion criteria. The primary outcome was the exposure leading to HP. Secondary outcomes included the disease stage at diagnosis, smoking rate, treatment modalities, ILD exacerbation rate, and mortality.Results:Birds and mold are the more common exposures attributed to HP (both n=2, 28.57%). Novel exposures to continuous positive airway pressure devices, vapor and/or fumes, and fiberglass were noted (each n=1, 14.28%). Three patients (42.85%) had fibrotic HP at presentation. Most patients were ever-smokers (n=4, 57.14%). All patients (n=7, 100%) received corticosteroids with a mean duration of use of 2.50 ± 0.65 months, and a mean dose of 37.14 ± 12.54 mg. One (14%) patient was compliant with antigen elimination. ILD exacerbation and mortality rate was high (both n=2, 28.57%).Conclusion:The exposures identified in rural Appalachian HP patients were similar to other rural and urban populations in the United States. Risk factors associated with poor outcomes, such as smoking, fibrotic HP subtype, and non-avoidance of antigen were higher in this cohort. The rate of ILD exacerbation and mortality were similarly higher. Larger studies are needed to investigate longitudinal trends of exposure, characteristics, and management of HP to improve outcomes in rural populations.
Clinical Similarity of Biosimilars and Reference Drugs: A Comprehensive Review and New Hope for Public Health in a New Frontier
Authors: Adatiya Mansi D. , Devani Aanal A. , Dudhia Vishal N. , Chorawala Mehul R. , Patel Vishvas N. , Patel Manish P. 
Published: November 2023

Background:
Patents and exclusive rights on reference biologics contribute to the
emergence of biosimilars. Regulatory bodies, such as the Food and Drug Administration
(FDA), World Health Organization (WHO), and EMA (European Medicines Agency) for assessing
clinical safety, effectiveness, and consequences between biosimilars and reference medications,
have established guidelines. Since generic small molecules from reference can be easily
swapped, biosimilars cannot be used interchangeably and may not always indicate interchangeability
due to highly restrictive properties. It can be replaced with a reference without the
healthcare provider's help under the interchangeability context.

Objective:
The purpose of our study is to analyze and compare evidence-based clinical safety,
therapeutic potential, and importance (outcomes) of several biosimilars with their references
along with clinical uses in chronic diseases.

Methods:
Through a comprehensive systemic literature review of more than 100 articles involving
medicinally important drugs whose bio-similarity works optimally, safety-efficacy parameters
have been analyzed. Analysis of biosimilar usage, approval, and safety-efficacy aspects are
majorly focused upon herein in this review.

Results:
From this systemic review, it can be stated that the majority of biosimilars are clinically
and statistically equivalent to their originators. As biosimilars have good safety-efficacy aspects
with lower prices, their utilization can be more encouraged, which was already done by
the FDA with the establishment of a public online database entitled "Purple Book," which includes
all information regarding biological drugs.

Conclusion:
To conclude, we suggest wide spread use of high-grade biosimilars in clinical
practice, may be via changing, exchanging, or switching, with appropriate clinical monitoring
and pharmacovigilance to improve patient accessibility to modern medicines, as it provides
similar efficacy and safety parameters across all the accumulated clinical trials and studies.
Exploring the Usability and Acceptability of a Well-Being App for Adolescents Living With Type 1 Diabetes: Qualitative Study
Authors: Garner Katie , Thabrew Hiran , Lim David , Hofman Paul , Jefferies Craig , Serlachius Anna 
Published: November 2023

Abstract

Background
Adolescents living with either type 1 diabetes (T1D) or type 2 diabetes (T2D) have an increased risk of psychological disorders due to the demands of managing a chronic illness and the challenges of adolescence. Psychological disorders during adolescence increase the risk of suboptimal glycemic outcomes and may lead to serious diabetes-related complications. Research shows that digital health interventions may increase access to psychological support for adolescents and improve physical and mental health outcomes for youth with diabetes. To our knowledge, there are no evidence-based, publicly available mental health apps with a focus on improving the psychological well-being of adolescents with diabetes.

Objective
This study aimed to explore the acceptability and usability of our evidence-based well-being app for New Zealand adolescents, Whitu: 7 Ways in 7 Days (Whitu), to allow us to further tailor it for youth with diabetes. We interviewed adolescents with T1D and T2D, their parents, and health care professionals to explore their views on the Whitu app and suggestions for tailoring the app for adolescent with diabetes. We also explored the cultural acceptability of the Whitu app for Māori and Pacific adolescents.

Methods
A total of 34 participants, comprising 13 adolescents aged 12-16 years (11 with T1D and 2 with T2D), 10 parents, and 11 health care professionals, were recruited from a specialist diabetes outpatient clinic and Facebook diabetes groups. Each participant attended one 1-hour focus group on Zoom, in person, or via phone. Researchers gathered general feedback on what makes an effective and engaging app for adolescents with diabetes, as well as specific feedback about Whitu. Transcribed audio recordings of the focus groups were analyzed using directed content analysis.

Results
Adolescents with T1D, their parents, and health care professionals found Whitu to be acceptable and usable. Adolescents with T1D and their parents signaled a preference for more diabetes-specific content. Health care professionals expressed less awareness and trust of digital health interventions and, as such, recommended that they be used with external support. Due to challenges in recruitment and retention, we were unable to include the views of adolescents with T2D in this qualitative study.

Conclusions
There appears to be sufficient openness to the use of an app such as Whitu for supporting the well-being of adolescents with T1D, albeit with modifications to make its content more diabetes specific. Based on this qualitative study, we have recently developed a diabetes-specific version of Whitu (called LIFT: Thriving with Diabetes). We are also planning a qualitative study to explore the views of youth with T2D and their perspectives on the new LIFT app, where we are using alternative research approaches to recruit and engage adolescents with T2D and their families.