bluuebunny/crossref_metadata_2025_split huggingface dataset:
A General Minisci‐Type Alkylation with Organoboron Derivatives Assisted by Catechol
Authors: Zhou Yutong , Yang Hui , Chen Xingyue , Peng Xiaowu , Yao Qiuli , Chen Gang 
Published: January 2024

AbstractThis manuscript describes a general strategy for the easily scale‐up alkylation of heterocycles with a wide variety of boronic acids, boronates, and trifluoroborate salts under low‐cost and simple conditions without using any transition‐metal or organo‐photocatalysts. The key additive of catechol plays an important role in this method which in‐situ activated a variety of boron‐base species to alkylboronic esters (R‐BCat) with a low oxidation potential. The transformation is distinguished by a broad scope, such as drug molecules and natural products. Furthermore, the methodology proves easily scalable under standard batch conditions, enhancing its practicality and accessibility.
Genetic and environmental contributions for the relationship between tooth loss and oral potentially malignant disorders and oral squamous cell carcinoma
Authors: da Silva Adriana M. , Falcão Michelle M. L. , Freitas Valéria S. , Vieira Alexandre R. 
Published: January 2024

AbstractBackgroundTo investigate the association between tooth loss and oral potentially malignant disorders and oral squamous cell carcinoma, focusing on epidemiological factors and genetic variants.MethodsCase–control study, including histologically confirmed oral potentially malignant disorders and oral squamous cell carcinoma cases and healthy controls. Unadjusted and adjusted odds ratios for this association were calculated. Single‐nucleotides polymorphisms were tested for individuals with and without missing teeth.ResultsCase individuals were more edentulous while controls had fewer missing teeth (p = 0.006). There was an increased risk for the outcomes associated with edentulism (OR = 6.95, p = 0.000), even after adjustments for educational level (OR = 4.7, p = 0.034) and smoking habits (OR = 5.01, p = 0.022). Among individuals with tooth loss, rs1533767 (WNT11), rs3923087, and rs11867417 (AXIN2) were associated with the outcomes (OR = 1.67, p = 0.03, OR = 0.53, p = 0.05, and OR = 0.42, p = 0.00, respectively).ConclusionsTooth loss could increase the risk for oral potentially malignant disorders and oral squamous cell carcinoma.
Preventive behaviors against COVID‐19 among health care providers in Iran: A cross‐sectional study
Authors: Niksirat Souri , Rouhani‐Tonekaboni Nooshin , Shakiba Maryam , Kasmaei Parisa 
Published: January 2024

AbstractBackground and AimDuring outbreaks of infectious diseases, if healthcare providers do not follow the principles of prevention, the risk of personal infection increases and they become a source of infection spread. This study aimed to determine the factors related to the preventive health behaviors of COVID‐19 among Iranian healthcare providers based on protection motivation theory (PMT).MethodsThis analytical cross‐sectional study included 346 healthcare providers. Data was collected by an online researcher‐made questionnaire based on PMT. To analyze the data, independent T tests, analysis of variance (ANOVA), Spearman correlation coefficient, multiple linear regression, and SPSS 22 software were used. α was considered as 0.05.Results85.3% of the healthcare providers would always wear masks, 80.7% would always refuse to kiss and touch hands with others, and 34.7% sometimes would exercise at home. The preventive behaviors were significantly correlated with protection motivation (r = 0.84), self‐efficacy (r = 0.51), response efficiency (r = 0.43), perceived severity (r = 0.41) Fear (r = 0.21), perceived susceptibility (r = 0.11), response cost (r = −0.14), and reward (r = −0.15). PMT constructs were able to predict 77% of the variance of the behaviors and the protection motivation construct was the strongest predictor (β = 0.806). Income above 300 Dolars per month was significantly related to the decrease in the mean score of preventive behaviors against COVID‐19. The female sex and the individual or family history of infectious diseases were significantly related to increasing the mean score of COVID‐19 preventive behaviors.ConclusionBased on the study results, it is suggested that some educational interventions be designed and implemented with a focus on this construct and the perceived severity construct and that more attention be given to the education of health care providers with high‐income levels, male providers, and the individuals without a history of corona infection in themselves or their family members.
Patient reported outcomes after multivisceral resection for advanced rectal cancers in female patients
Authors: Kazi Mufaddal , Choubey Katyayani , Patil Pooja , Jaiswal Dushyant , Ajmera Sejal , Desouza Ashwin , Saklani Avanish 
Published: January 2024

AbstractIntroductionMultivisceral resections for rectal cancer can lead to long‐term functional disturbances. This study aims to evaluate the quality‐of‐life outcomes in female patients who underwent multivisceral resection for rectal cancer, specifically focusing on urinary and sexual functions.MethodsA cross‐sectional study was conducted on female patients who underwent multivisceral rectal resections. Quality of life was assessed using the EORTC QLQ‐CR29.ResultsOut of 198 female patients that underwent multivisceral resections, 69 were assessable for functional outcomes. The uterus was removed in 42 patients (61%), and the posterior vaginal wall in 34 (49%). A vaginal reconstructive procedure was carried out in 30% (21 patients). Patients reported the most troubles with urinary frequency (mean: 69.6; SD: 9.9), hair loss (mean: 64.7; SD: 13.9), pain during intercourse (mean: 44; SD: 40.7), and bowel frequency (mean: 36.9; SD: −10.7) in this order. Amongst the functional scales, anxiety about future health (mean: 42.5; SD: −018.9) and interest in sex (mean: 57.2; SD: 33.2) scored the lowest.ConclusionMultivisceral rectal resections in female patients are associated with physical and psychosocial changes resulting in urinary and bowel complaints, anxiety about future health, poor sexual health, and pain.
Silencing lncRNA‐DARS‐AS1 suppresses nonsmall cell lung cancer progression by stimulating miR‐302a‐3p to inhibit ACAT1 expression
Authors: Li Ji , Li Yizhuo , Sun Xiaodan , Wei Lai , Guan Jingqian , Fu Lin , Du Jiang , Zhang Xiupeng , Cheng Ming , Ma Huan , Jiang Siyu , Zheng Qianqian , Wang Liang 
Published: January 2024

AbstractLong noncoding RNAs (LncRNAs) have been gaining attention as potential therapeutic targets for lung cancer. In this study, we investigated the expression and biological behavior of lncRNA DARS‐AS1, its predicted interacting partner miR‐302a‐3p, and ACAT1 in nonsmall cell lung cancer (NSCLC). The transcript level of DARS‐AS1, miR‐302a‐3p, and ACAT1 was analyzed using qRT‐PCR. Endogenous expression of ACAT1 and the expression of—and changes in—AKT/ERK pathway‐related proteins were determined using western blotting. MTS, Transwell, and apoptosis experiments were used to investigate the behavior of cells. The subcellular localization of DARS‐AS1 was verified using FISH, and its binding site was verified using dual‐luciferase reporter experiments. The binding of DARS‐AS1 to miR‐302a‐3p was verified using RNA co‐immunoprecipitation. In vivo experiments were performed using a xenograft model to determine the effect of DARS‐AS1 knockout on ACAT1 and NSCLC. lncRNA DARS‐AS1 was upregulated in NSCLC cell lines and tissues and the expression of lncRNA DARS‐AS1 was negatively correlated with survival of patients with NSCLC. Knockdown of DARS‐AS1 inhibited the malignant behaviors of NSCLC via upregulating miR‐302a‐3p. miR‐302a‐3p induced suppression of malignancy through regulating oncogene ACAT1. This study demonstrates that the DARS‐AS1‐miR‐302a‐3p‐ACAT1 pathway plays a key role in NSCLC.
Direct estimation of the noise power spectrum from patient data to generate synthesized CT noise for denoising network training
Authors: Han Minah , Baek Jongduk 
Published: January 2024

AbstractBackgroundDeveloping a deep‐learning network for denoising low‐dose CT (LDCT) images necessitates paired computed tomography (CT) images acquired at different dose levels. However, it is challenging to obtain these images from the same patient.PurposeIn this study, we introduce a novel approach to generate CT images at different dose levels.MethodsOur method involves the direct estimation of the quantum noise power spectrum (NPS) from patient CT images without the need for prior information. By modeling the anatomical NPS using a power‐law function and estimating the quantum NPS from the measured NPS after removing the anatomical NPS, we create synthesized quantum noise by applying the estimated quantum NPS as a filter to random noise. By adding synthesized noise to CT images, synthesized CT images can be generated as if these are obtained at a lower dose. This leads to the generation of paired images at different dose levels for training denoising networks.ResultsThe proposed method accurately estimates the reference quantum NPS. The denoising network trained with paired data generated using synthesized quantum noise achieves denoising performance comparable to networks trained using Mayo Clinic data, as justified by the mean‐squared‐error (MSE), structural similarity index (SSIM)and peak signal‐to‐noise ratio (PSNR) scores.ConclusionsThis approach offers a promising solution for LDCT image denoising network development without the need for multiple scans of the same patient at different doses.
Is there evidence for pelvic floor muscle relaxation training in nonneurogenic female bladder outlet obstruction?—A narrative review
Authors: Bø Kari 
Published: January 2024

AbstractIntroductionFunctional bladder outlet obstruction (BOO) in women is postulated to be caused by pelvic floor muscle (PFM) dyssynergia or increased tone. The aim of the present review was to investigate the effect of PFM relaxation training on PFM tone and female BOO symptoms.Materials and MethodsThis was a narrative review using an open search strategy on PubMed with the search terms “Bladder outlet obstruction” AND “female” AND (“pelvic floor muscles” OR “Kegel”). The risk of bias of the randomized controlled trials (RCTs) was scored with the Physiotherapy Evidence Database (PEDro) scale (0–10).ResultsOnly three RCTs were found. All three RCTs compared different types of exercise, and no trial compared relaxation training with no or sham treatment. None of the trials reported the effect between groups on the reduction of PFM tone. There was a tendency toward positive effect of PFM relaxation training to improve BOO symptoms in women. PEDro score varied between 4 and 7. Few studies yielded information on the immediate effect of any type of PFM relaxation technique on PFM tone.ConclusionFew RCTs have been conducted on the effect of PFM relaxation training on PFM tone and functional female BOO symptoms. There is an urgent need for RCTs with high methodological and interventional quality in addition to basic research on mechanisms of different relaxation techniques on PFM activity.
Bladder outlet obstruction in women: Advanced evaluation
Authors: Lec Patrick M. , Nitti Victor W. 
Published: January 2024

AbstractIntroductionHerein, we provide a review of the indications, practical considerations, and interpretation of urodynamics (UDS) with or without fluoroscopy, as well as cystourethroscopy, for women with suspected bladder outlet obstruction (BOO).Methods and ResultsA narrative review was performed focusing on the current primary literature and society guidelines around advanced diagnostic modalities for female BOO patients. UDS studies help diagnose BOO by identifying high‐pressure low‐flow voiding patterns and/or the characteristic radiographic appearance of the bladder neck and urethra during micturition. Cystourethroscopy aids in evaluating structural aberrations of the bladder outlet, and in surgical planning.ConclusionsUDS studies and cystourethroscopy are useful adjuncts in carefully‐selected female patients with suspected BOO.
Association between frailty and detrusor overactivity with detrusor underactivity in older women
Authors: Ly Ong Damien , Monaghan Thomas F. , Chartier‐Kastler Emmanuel , Petrovic Mirko , Goessaert An‐Sofie , Everaert Karel , Robain Gilberte , Haddad Rebecca ,   NOPIA Research Group
Published: January 2024

AbstractPurposeWhile detrusor overactivity (DO) with detrusor underactivity (DU) (DO‐DU) has been described as typical of aging, the pathogenesis of DO‐DU is highly multifactorial, and often thought to involve medical conditions beyond the urinary tract. We aimed to explore potential associations between idiopathic DO‐DU and frailty in older women after accounting for age.MethodsThe design of the study is a cross‐sectional single‐center study, in an outpatient urodynamic unit specializing in geriatrics. Participants are consecutive female patients aged ≥65 years without contributory neurological conditions or bladder outlet obstruction who completed a comprehensive geriatric assessment followed by urodynamic evaluation from 2015 to 2019. Participants were categorized as having DO, DU, combined DO‐DU, or a negative study. Multinomial logistic regression analysis was used to assess the relationship between urodynamic outcomes and frailty, as quantified using the Frailty index (FI).ResultsNinety‐five patients were included (median age 78 [interquartile range: 70–83] years), among whom 29% had combined DO‐DU. The median FI score was 0.27 (0.2–0.32) (5–12). A higher FI was associated with significantly greater age‐adjusted odds of DO‐DU when either DU or subjects with a negative urodynamic assessment were used as the reference group. Age was not significantly associated with DO‐DU across all multivariable analyses.ConclusionA higher FI was associated with an increased likelihood of DO‐DU, which could not be attributed to the effect of age alone. The pathogenesis of DO‐DU is likely more complex than chronological aging in and of itself and merits further study.
Preparation of GNP/SBR thermal conductivity composites with high strength and toughness by synergistic construction of interfacial multiple non‐covalent and covalent bonds
Authors: Li Fangshan , Wang Heng , Ke Yuchao , Hu Yuan , Xia Ru 
Published: January 2024

Abstract[AMIm]Cl@GNP/SBR composites were prepared by blending ionic liquid 1‐allyl‐3‐methylimidazolium chloride salt([AMIm]Cl) modified graphene nanoplatelets (GNP) and styrene‐butadiene rubber (SBR). The mechanical and thermal properties as well as the structure–activity relationship of the obtained composites based on the modified filler were investigated under the synergistic effect of non‐covalent and covalent bonding. The experimental results indicated that the modification of GNP by [AMIm]Cl occurred under mild conditions. The dispersibility of [AMIm]Cl@GNP in SBR was enhanced by its participation in vulcanization and the synergistic effect of non‐covalent and covalent cross‐linking networks such as cation‐π, π‐π, and hydrogen bonds. This improvement led to an increase in the interfacial bond strength of the composites and a reduction in the interfacial thermal resistance. These effects resulted in both reinforcement and thermal conductivity properties. The tensile strength and elongation at break of [AMIm]Cl@GNP/SBR composites increased from 18.2 to 22.9 MPa and from 737.9% to 923.5%, respectively, when the modification ratio of [AMIm]Cl was 1% and the loading of [AMIm]Cl@GNP was only 4 phr (mass ratio). At the same time, the thermal conductivity in the vertical direction of the composites increased from 0.25 to 0.44 W/(m·K), and the thermal conductivity in the horizontal direction increased from 0.27 to 0.81 W/(m·K).Highlights
Modified powder [AMIm]Cl@graphene nanoplatelets were prepared;
[AMIm]Cl@graphene nanoplatelet/styrene‐butadiene rubber blend was prepared;
Mechanical properties of blends significantly improved over blank;
The horizontal thermal conductivity of the blends increases obviously;
The vertical thermal conductivity of the blends was improved.
Insecticide resistance status of Aedes aegypti in border areas of Yunnan Province
Authors: Wang Ge , Zhang HengDuan , Gao Jian , Ma Zu , Du YuTong , Liu Qing , Liu Yuan , Xing Dan , Guo XiaoXia , Zhao Teng , Jiang YuTing , Li ChunXiao , Zhao TongYan 
Published: January 2024

AbstractBACKGROUNDAedes aegypti is a main vector of arboviral diseases, principally dengue, chikungunya, and Zika. Insecticides remain the most effective vector control method. Pyrethroid is the main insecticide currently used, and the long‐term use of insecticides can cause mosquitoes to develop knockdown resistance. Studying the mutation sites and genotypes of Ae. aegypti can reveal the mutation characteristics and regional distribution of the kdr gene in an Ae. aegypti population. Testing for a correlation between the mutation rate in various populations and pyrethrin resistance can clarify the resistance mechanism.RESULTSThe bioassay results showed that all 15 populations are resistant. In the study of the kdr gene, three non‐synonymous mutations were identified in the DNA of first generation females from the wild Ae. aegypti population: S989P (TCC‐CCC), V1016G (GTA‐GGA), and F1534C (TTC‐TGC). The mortality rate of the various populations was correlated with the mutation rate at the V1016G + F1534C locus, but not the S989P + V1016G locus.CONCLUSIONAedes aegypti populations in border regions of Yunnan Province are resistant to permethrin and beta‐cyfluthrin. The insecticidal effect of beta‐cyfluthrin is stronger than that of permethrin. The mutation rate at sites V1016G + F1534C is negatively correlated with the mortality of Ae. aegypti based on bioassays. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Creep and shrinkage in prestressed concrete beams: An experimental study
Authors: Williams Mary , Menon Devdas , Prasad A. Meher 
Published: January 2024

AbstractThe existing creep and shrinkage models used for predicting long‐term behavior of prestressed concrete (PSC) beams are originally developed for cylinders under axial compression. This experimental study investigates the creep behavior in axial and flexural compression and attempts to verify the suitability of the standard models for application in PSC beams. The study is carried out by monitoring the strains and the prestress losses in four PSC beams having the same cross‐section, subject to prestress loading alone, and the strains in two axially loaded cylinders, under ambient environmental conditions for a duration of 365 days. The effects of drying, stress gradient across the depth, bonding of prestressing steel, and high reinforcement have been considered. The experimental results have been compared with the predictions by six standard models (AASHTO, ACI 209R‐92, GL 2000, B3, MC2010, and Eurocode model). For the PSC beams, the predictions from standard models are based on a numerical three‐dimensional finite element model that accounts for the stress variation with time due to prestress loss and the effect of reinforcement. The results show that creep behavior in flexural compression is different from that in axial compression and most of the standard models over‐estimate the strains in PSC beams considered in the present study. The study also provides an overview of the relative accuracies of the standard models and has practical relevance in the design of PSC bridges and estimation of prestress loss.
Netflix’s Lupin: Cultural Heritage and Internationalisation in the Age of Global (S)VoD Platforms
Authors: Pettersen David 
Published: January 2024

AbstractThis chapter considers questions of media internationalisation and localisation in the contemporary age of globalised subscription video-on-demand ((S)VoD) platforms through a case study of Netflix’s French series Lupin (2020–). The author examines the production history of the series and the adaptation practices of Netflix’s collaboration with the French studio Gaumont to transform the source novels into a star vehicle for France’s best-known Black star, Omar Sy. Rather than a mannered heritage series, Lupin offers a hyper-contemporary, cosmopolitan and entertainment-oriented adaptation that fuses past and present. This chapter analyses how the series transforms the source novels into a contemporary tale of colonial exploitation, diaspora and social integration that speaks to different audiences around the world.
Materialities of Home in Migration
Authors: Fathi Mastoureh , Ní Laoire Caitríona 
Published: January 2024

AbstractThis chapter focuses on materiality of migrant homes and the relationships between objects in migration and social processes that make certain material components of a home more meaningful and useful than others. The chapter acknowledges that the space of home is not separate from the larger socio-political structures that make it possible or impossible. However, it turns the lens of analysis towards a more mundane and everyday aspect of home making practices, that is, material composition of a home. This chapter highlights three important areas in studies of objects in home and migration processes: the first are objects of memory, that capture symbolic meanings in relation to past lives, homes and contexts. The second is about objects of everyday use, that refers to instrumentality of objects and their usefulness as tools in present times. The third one is about objects that convey a form of identity (such as in relation to class, gender, nation) that is useful for one in relation to their desired homes or even homes for future.
Radiological age assessment based on clavicle ossification in CT: enhanced accuracy through deep learning
Authors: Wesp Philipp , Schachtner Balthasar Maria , Jeblick Katharina , Topalis Johanna , Weber Marvin , Fischer Florian , Penning Randolph , Ricke Jens , Ingrisch Michael , Sabel Bastian Oliver 
Published: January 2024

Abstract
Background
Radiological age assessment using reference studies is inherently limited in accuracy due to a finite number of assignable skeletal maturation stages. To overcome this limitation, we present a deep learning approach for continuous age assessment based on clavicle ossification in computed tomography (CT).

Methods
Thoracic CT scans were retrospectively collected from the picture archiving and communication system. Individuals aged 15.0 to 30.0 years examined in routine clinical practice were included. All scans were automatically cropped around the medial clavicular epiphyseal cartilages. A deep learning model was trained to predict a person’s chronological age based on these scans. Performance was evaluated using mean absolute error (MAE). Model performance was compared to an optimistic human reader performance estimate for an established reference study method.

Results
The deep learning model was trained on 4,400 scans of 1,935 patients (training set: mean age = 24.2 years ± 4.0, 1132 female) and evaluated on 300 scans of 300 patients with a balanced age and sex distribution (test set: mean age = 22.5 years ± 4.4, 150 female). Model MAE was 1.65 years, and the highest absolute error was 6.40 years for females and 7.32 years for males. However, performance could be attributed to norm-variants or pathologic disorders. Human reader estimate MAE was 1.84 years and the highest absolute error was 3.40 years for females and 3.78 years for males.

Conclusions
We present a deep learning approach for continuous age predictions using CT volumes highlighting the medial clavicular epiphyseal cartilage with performance comparable to the human reader estimate.