bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation and comparison of the coding algorithms to identify people with migraine using Japanese claims data
Authors: Yamato Kentaro , Sano Hiromi , Hirata Koichi , Nakayama Takeo 
Published: November 2023

PurposeThe study aimed to validate and compare coding algorithms for identifying people with migraine within the Japanese claims database.MethodsThis study used the administrative claim database provided by DeSC Healthcare, Inc., that was linked to the results of an online survey administered to adult users of the health app “kencom®.” The ability of the 12 algorithms to detect migraines using diagnostic records alone or with prescription records was evaluated based on sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs). We used a migraine diagnosis judged based on respondents' self-reported symptoms according to the diagnostic criteria of the International Classification of Headache Disorders, version 3 (ICHD-3), as true.ResultsOf the 21,480 individuals, 691 had migraine according to the ICHD-3 criteria. The 12 algorithms had a sensitivity of 5.4–8.8%, specificity of 98.8–99.6%, PPVs of 19.2–32.5%, and NPVs of 96.9–97.0%. Algorithm 9 (migraine diagnostic records more than once AND at least one prescription record for migraine prophylaxis or triptans in the same month as diagnosis) produced the highest PPV, whereas Algorithm 2 (at least one diagnostic record of migraine or tension-type headache) had the highest sensitivity. Similar trends were observed when using the ID-Migraine or 4-item migraine screener, instead of the ICHD-3 criteria, for case ascertainment.ConclusionStrict algorithms, such as Algorithm 9, yielded a higher PPV but a lower sensitivity, and such algorithms may be suitable for studies estimating the relative risk. Conversely, algorithms based on a single diagnostic record, such as Algorithm 2, had a higher sensitivity and may be suitable for studies estimating the prevalence/incidence of disease. Our findings will help select a desirable algorithm for migraine studies using a Japanese claim database.
Embodied strategies for public speaking anxiety: evaluation of the Corp-Oral program
Authors: García-Monge Alfonso , Guijarro-Romero Santiago , Santamaría-Vázquez Eduardo , Martínez-Álvarez Lucio , Bores-Calle Nicolás 
Published: November 2023

BackgroundPublic speaking is an indispensable skill that can profoundly influence success in both professional and personal spheres. Regrettably, managing anxiety during a speech poses a significant challenge for many of the population. This research assessed the impacts of a Corp-Oral program, designed to manage public speaking anxiety in university students, based on, body awareness, embodied message techniques, simulation, embodied visualization, body transformation, and gesture enhancement.MethodsThirty-six students (61% women; Mage= 20.22, SD = 1.23 years) were randomly assigned to either an experimental group (n= 18), which underwent the Corp-Oral program, or a control group (n= 18). Self-perceived anxiety, heart rate, and electroencephalography were measured in a pre-test and a post-test.ResultsThe study reveals that the Corp-Oral program significantly (p&lt; 0.005) reduced both physiological responses (heart rate) and self-reported measures of anxiety. The alteration was more noticeable in self-reported anxiety measures (a decrease of 33.217%) than in heart rate (a decrease of 4.659%). During the speech, the experimental group exhibited increased cortical activation in areas related to emotional regulation, consciousness, sensorimotor integration, and movement control. A significant increase in frontal alpha asymmetry was observed for the experimental group in the post-test, but there were no significant variations in the theta/beta ratio.ConclusionThese findings underline the benefit of managing public speaking anxiety not merely by reducing it but by channeling it through embodied strategies. These strategies could lead to greater action awareness that would cushion the physiological effect of the anxiety response and help generate a better self-perception of the anxiety state.
High-beta oscillations at EEG resting state and hyperconnectivity of pain circuitry in fibromyalgia: an exploratory cross-sectional study
Authors: Alves Rael Lopes , Zortea Maxciel , Serrano Paul Vicuña , Brugnera Tomedi Rafaela , Pereira de Almeida Rodrigo , Torres Iraci L. S. , Fregni Felipe , Caumo Wolnei 
Published: November 2023

BackgroundElectroencephalography (EEG) has identified neural activity in specific brain regions as a potential indicator of the neural signature of chronic pain. This study compared the lagged coherence connectivity between regions of interest (ROIs) associated with the pain connectome in women with fibromyalgia (FM) and healthy women (HC).MethodsWe evaluated 64 participants (49 FM and 15 HC) during resting-state EEG sessions under both eyes open (EO) and eyes closed (EC) conditions. In addition to EEG measurements, we assessed clinical and psychological symptoms and serum levels of brain-derived neurotrophic factor (BDNF). The connectivity between eight ROIs was computed across eight different EEG frequencies.ResultsThe FM group demonstrated increased connectivity between the left dorsolateral prefrontal cortex (DLPFC) and right anterior cingulate cortex (ACC), specifically in the beta-3 frequency band (t = 3.441, p = 0.044). When comparing the EO and EC conditions, FM patients exhibited heightened interhemispheric connectivity between insular areas (t  = 3.372, p = 0.024) and between the left insula (INS) and right DLPFC (t = 3.695, p = 0.024) within the beta-3 frequency band. In the EC condition, there was a negative correlation between pain disability and connectivity in the beta-3 frequency band between the left ACC and the left primary somatosensory cortex (SI; r = −0.442, p = 0.043). In the EO condition, there was a negative correlation between central sensitization severity and lagged coherence connectivity in the alpha-2 frequency band between the right ACC and left SI (r = 0.428, p = 0.014). Moreover, in the EO–EC comparison, the lagged coherence connection between the left DLPFC and right INS, indexed by the gamma frequency band, showed a negative correlation with serum BDNF levels (r = −0.506, p = 0.012).ConclusionThese findings indicate that increased connectivity between different pain processing circuits, particularly in the beta-3 frequency band during rest, may serve as neural biomarkers for the chronic pain brain signature associated with neuroplasticity and the severity of FM symptoms.
Case Report: Post-traumatic splenosis and potential pitfall for PSMA-PET
Authors: Nearchou Marina , Georgiou Elizabeth , Vrachimis Alexis , Ferentinos Konstantinos , Strouthos Iosif 
Published: November 2023

Background18F-prostate specific membrane antigen (PSMA) PET is fast becoming the gold-standard in prostate cancer, both in staging of intermediate-/high-risk patients and in re-staging patients with biochemical failure. Several pitfalls of 18F-PSMA PET have been reported, and we report, to our best of knowledge, for the first time, a case which could have been falsely diagnosed as peritoneal spread.Case presentationA 67-year-old patient with high-risk prostate cancer underwent staging with 18F-PSMA-1007 PET/CT (PSMA-PET/CT). PSMA-PET/CT revealed a histologically confirmed prostatic malignancy in the peripheral left zone. Unexpectedly, additional multiple highly PSMA-expressing intraabdominal formations were discovered. Based on apparent anatomic asplenia and a history of traumatic splenic rapture during childhood, a suspicion of post-traumatic splenosis was raised. For further non-invasive evaluation, a C-99 sulphur colloid scintigraphy with SPECT was conducted, confirming the presence of multiple functional ectopic splenic tissues. This is, to our best of knowledge, the first case utilising 18F-PSMA-1007-PET/CT and 99mTc-sulphur colloid SPECT to detect intraabdominal splenosis, highlighting the high potential of nuclear medicine in such trivial cases.
Eating behavior of adolescent girls in countries with a high prevalence of stunting under five: a systematic review
Authors: Setiawan Arlette Suzy , Budiarto Arief , Indriyanti Ratna 
Published: November 2023

BackgroundAdolescence is critical for physical and psychological growth, making healthy dietary behavior essential. Several countries face nutritional challenges due to a high prevalence of stunting in children under five, which can impact adolescent girls’ eating behavior. This systematic review aims to provide evidence on the eating behavior of adolescent girls in such countries, offering insights for stunting prevention programs.MethodsWe conducted a systematic review following PRISMA guidelines and registered it in PROSPERO. We employed a comprehensive search strategy across multiple databases. Study selection involved three stages: deduplication, title/abstract screening, and full-text review, with inter-reviewer agreement assessment.ResultsThe search identified 15 eligible studies from various countries, primarily utilizing cross-sectional designs. The studies focused on age ranges within adolescence and varied in sample size and assessment tools. The primary objective of these studies was to assess eating behavior, with outcomes related to dietary patterns, eating disorders, body image, and nutritional knowledge. The results revealed diverse eating behaviors among adolescent girls, including restrained eating, dieting for weight loss, craving-induced eating, and unhealthy dietary patterns. Many girls exhibited low dietary diversity, contributing to micronutrient deficiencies.SuggestionsTo address these issues effectively, stunting prevention programs and policies should prioritize the following strategies: implementing comprehensive nutritional education programs to enhance adolescents’ knowledge of healthy eating habits and dietary diversity, providing resources and support for positive body image development to reduce the pressure for unhealthy dieting, improving access to affordable, nutrient-rich foods in both urban and rural areas, raising awareness about eating disorders and emphasizing early identification and intervention, engaging parents, caregivers, and communities in promoting healthy eating behaviors, and maintaining rigorous research and monitoring to adapt strategies based on evolving trends in adolescent eating behaviors.ConclusionAdolescent girls in countries with high stunting prevalence exhibit diverse eating behaviors that can impact their nutritional status and overall health. Addressing these behaviors is essential to prevent stunting and its long-term consequences, emphasizing the importance of comprehensive strategies and support for this vulnerable population.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD42023389909.
Impact of health risk factors on healthcare resource utilization, work-related outcomes and health-related quality of life of Australians: a population-based longitudinal data analysis
Authors: Mi Jun , Ishida Marie , Anindya Kanya , McPake Barbara , Fitzgibbon Bernadette , Laverty Anthony A. , Tran-Duy An , Lee John Tayu 
Published: November 2023

BackgroundHealth risk factors, including smoking, excessive alcohol consumption, overweight, obesity, and insufficient physical activity, are major contributors to many poor health conditions. This study aimed to assess the impact of health risk factors on healthcare resource utilization, work-related outcomes and health-related quality of life (HRQoL) in Australia.MethodsWe used two waves of the nationally representative Household, Income, and Labor Dynamics in Australia (HILDA) Survey from 2013 and 2017 for the analysis. Healthcare resource utilization included outpatient visits, hospitalisations, and prescribed medication use. Work-related outcomes were assessed through employment status and sick leave. HRQoL was assessed using the SF-6D scores. Generalized estimating equation (GEE) with logit or log link function and random-effects regression models were used to analyse the longitudinal data on the relationship between health risk factors and the outcomes. The models were adjusted for age, sex, marital status, education background, employment status, equilibrium household income, residential area, country of birth, indigenous status, and socio-economic status.ResultsAfter adjusting for all other health risk factors covariates, physical inactivity had the greatest impact on healthcare resource utilization, work-related outcomes, and HRQoL. Physical inactivity increased the likelihood of outpatient visits (AOR = 1.60, 95% CI = 1.45, 1.76 p &lt; 0.001), hospitalization (AOR = 1.83, 95% CI = 1.66–2.01, p &lt; 0.001), and the probability of taking sick leave (AOR = 1.31, 95% CI = 1.21–1.41, p &lt; 0.001), and decreased the odds of having an above population median HRQoL (AOR = 0.48, 95% CI = 0.45–0.51, p &lt; 0.001) after adjusting for all other health risk factors and covariates. Obesity had the greatest impact on medication use (AOR = 2.02, 95% CI = 1.97–2.29, p &lt; 0.001) after adjusting for all other health risk factors and covariates.ConclusionOur study contributed to the growing body of literature on the relative impact of health risk factors for healthcare resource utilization, work-related outcomes and HRQoL. Our results suggested that public health interventions aim at improving these risk factors, particularly physical inactivity and obesity, can offer substantial benefits, not only for healthcare resource utilization but also for productivity.
Effects of Climate Change and Fire on the Middle and Late Holocene Forest History in Yenisei Siberia
Authors: Novenko Elena , Rudenko Olga , Mazei Natalia , Kupriyanov Dmitriy , Andreev Rodion , Shatunov Anton , Kusilman Maria , Prokushkin Anatoly , Olchev Alexander 
Published: November 2023

This study presents the long-term forest history in the forest–tundra ecotone of the Low Yenisei River basin. The new high-resolution pollen and macroscopic charcoal data were inferred from the 8.6 m long peat archive covering the last 6300 years. Climate reconstructions are based on the application of the best modern analogue technique using pollen data. Our findings suggest an alternation of phases of middle-taiga forests of Larix sibirica, Abies sibirica, Picea obovata, and Pinus sibirica (intervals of climate warming: 6320–6050, 5790–5370, 4480–4220, and 3600–2700 cal yr BP, respectively) and open larch woodlands with the participation of Betula, Picea, and Pinus sibirica, typical for northern taiga (intervals of climate cooling and increasing humidification: 5370–4480, 4220–3600 cal yr BP, respectively). The vegetation pattern of the region became similar to the modern one around 2700 cal yr BP. Climate warming caused a northward shift of vegetation-zone boundaries in Yenisei Siberia and an expansion of the range of Abies sibirica by about 200 km to the north compared to the present day. The increased frequency of fires and biomass burning during warm periods may promote the melting of the local permafrost, thereby enhancing the tree growth and regeneration.
Identification of Flavanone 3-Hydroxylase Gene Family in Strawberry and Expression Analysis of Fruit at Different Coloring Stages
Authors: Zhang Yanqi , Feng Yongqing , Yang Shangwen , Qiao Huilan , Wu Aiyuan , Yang Jinghua , Ma Zonghuan 
Published: November 2023

The color of strawberry fruit is an important appearance quality index that affects the marketability of fruit, and the content and type of anthocyanin are two of the main reasons for the formation of fruit color. At present, the research on anthocyanin synthesis mainly focuses on the phenylpropane metabolic pathway, and the F3H gene family is an important member of this metabolic pathway. Therefore, in order to clarify the role of flavanone 3-hydroxylase (F3H) in regulating anthocyanin accumulation in strawberry, we identified F3H gene family members in strawberry and analyzed their bioinformatics and expression at different fruit color stages. The results showed that the strawberry F3H family contains 126 members, which are distributed on seven chromosomes and can be divided into six subgroups. The promoter region of strawberry F3H gene family contains light response elements, abiotic stress response elements and hormone response elements. Intraspecic collinearity analysis showed that there were six pairs of collinearity of the F3H gene. Interspecific collinearity analysis showed that there were more collinearity relationships between strawberry and apple, grape and Arabidopsis, but less collinearity between strawberry and rice. Via tissue-specific expression analysis, we found that the expression levels of FvF3H48, FvF3H120 and FvF3H74 were higher in the stages of germination, growth, flowering and fruit setting. The expression levels of FvF3H42 and FvF3H16 were higher in seeds. The expression levels of FvF3H16 and FvF3H11 were higher in the ovary wall of stage 1, stage 2, stage 3 and stage 5. FvF3H15 and FvF3H48 were highly expressed in the pericardium, anther, receptacle and anther. Real-time fluorescence quantitative PCR showed the expression changes in F3H in the fruit coloring process. The results indicate that the expression levels of most members were higher during the S3 stage, such as FvF3H7, FvF3H16, FvF3H32, FvF3H82, FvF3H89, FvF3H92 and FvF3H112. FvF3H63 and FvF3H104 exhibited particularly high expression levels during the S1 stage, with some genes also showing elevated expression during the S4 stage, including FvF3H13, FvF3H27, FvF3H66 and FvF3H103. FvF3H58, FvF3H69, FvF3H79 and FvF3H80 showed higher expression levels during the S2 stage. These findings lay the groundwork for elucidating the biological functions of the strawberry F3H gene family and the selection of related genes.
Data Journalism and Network Theory: A Study of Political Communication through X (Formerly Twitter) Interactions
Authors: Samalis Alexandros , Spyropoulos Alexandros Z. , Makris Georgios C. , Bratsas Charalampos , Veglis Andreas , Tsiantos Vassilis , Baliou Anthoula , Garoufallou Emmanouel , Ventouris Anastasios 
Published: November 2023

This study investigates the research questions: “How do political connections within Greece’s governing party evolve, and what underlying patterns and dynamics are revealed through a network analysis of interactions on X (formerly Twitter)?” To address these questions, data were collected from X, focusing on following, retweeting, and mentioning activities among the politicians within the governing party. The interactions were meticulously analysed using tools derived from Network Theory in mathematics, including in and out-strength centrality, hubs and authorities centralities, and in and out-vertex entropy. In line with the emerging field of data journalism, this approach enhances the rigour and depth of analysis, facilitating a more nuanced understanding of complex political landscapes. The findings reveal complex and dynamic structures that may reflect internal relationships, communication strategies, and the influence of recurring events on these connections within the party. This study thus provides novel insights into understanding political communication via social networks and demonstrates the applicative potential of Network Theory and data journalism techniques in social sciences.
Photodynamic Eradication of Pseudomonas aeruginosa with Ru-Photosensitizers Encapsulated in Enzyme Degradable Nanocarriers
Authors: Kaur Kawaljit , Müller Max , Müller Mareike , Schönherr Holger 
Published: November 2023

The development of new approaches for the treatment of the increasingly antibiotic-resistant pathogen Pseudomonas aeruginosa was targeted by enhancing the effect of local antimicrobial photodynamic therapy (aPDT) using poly(ethylene glycol)-block-poly(lactic acid) (PEG114-block-PLAx) nanocarriers that were loaded with a ruthenium-based photosensitizer (PS). The action of tris(1,10-phenanthroline) ruthenium (II) bis(hexafluorophosphate) (RuPhen3) encapsulated in PEG114-block-PLAx micelles and vesicles was shown to result in an appreciable aPDT inactivation efficiency against planktonic Pseudomonas aeruginosa. In particular, the encapsulation of the PS, its release, and the efficiency of singlet oxygen (1O2) generation upon irradiation with blue light were studied spectroscopically. The antimicrobial effect was analyzed with two strains of Pseudomonas aeruginosa. Compared with PS-loaded micelles, formulations of the PS-loaded vesicles showed 10 times enhanced activity with a strong photodynamic inactivation effect of at least a 4.7 log reduction against both a Pseudomonas aeruginosa lab strain and a clinical isolate collected from the lung of a cystic fibrosis (CF) patient. This work lays the foundation for the targeted eradication of Pseudomonas aeruginosa using aPDT in various medical application areas.
One-step liquid-phase synthesis of platinum nanocatalysts supported on carbon fiber substrates and their electrochemical characterization
Authors: Yamagiwa Kiyofumi , Kamimura Kyohei , Kimura Yuuri 
Published: November 2023

Abstract
Highly dispersed Pt nanoparticles supported on polyacrylonitrile-based carbon fiber substrates were prepared using a one-step liquid-phase process. Nanoparticles were grown on the fiber surface via electric resistance heating of the substrate in ethanol solutions containing a platinum-based organometallic complex as the nanoparticle precursor. After the synthesis, Pt nanoparticles were formed on the surface in highly dispersed states. Electrochemical characterization of the Pt nanoparticles was conducted using the substrates directly after synthesis. The Pt nanoparticles were electrochemically active and exhibited superior methanol oxidation properties.
Toward 3GPP Sidelink-Based Millimeter Wave Wireless Personal Area Network for Out-of-Coverage Scenarios
Authors: Koda Yusuke , Okura Ryogo , Harada Hiroshi 
Published: November 2023

<p>With advancements in distributed autonomous systems (e.g., vehicles, sensors, and robots) in the 5G/6G era, sidelink communication technology has evolved as a distributed communication system in the third generation partnership project (3GPP). However, the current low-rate point-to-point sidelink communication design is not suitable for rapid development of such autonomous systems. Instead, based on sidelink, developing distributed wireless personal area networks (WPANs) with a drastically higher rate are essential. The overarching goal of this study is to explore the possibility of sidelink communication evolution to 1) form a distributed and autonomous WPAN and 2) support millimeter wave (mmWave) bands. Our core idea is to merge several design concepts of the precedented mmWave WPAN standards, i.e., IEEE 802.15.3c/11ad, into the sidelink communications, thereby bridging the gap between the two separated systems. This paper presents the anatomy of the IEEE 802.15.3c/11ad system with a focus on the formation of mmWave WPANs among distributed nodes and their operation. In addition, the current status of sidelink communication system design is highlighted, along with the missing building blocks, which are required to develop 3GPP sidelink-based mmWave WPAN systems. Simulation results on network formation signaling in the mmWave WPANs shed light on merging IEEE 802.15.3c/11ad concepts into 3GPP sidelink communication.</p>
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