bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproductive Profile of Neuronal Androgen Receptor Knockout Female Mice With a Low Dose of DHT
Authors: Ubba Vaibhave , Joseph Serene , Awe Olubusayo , Jones Dustin , Dsilva Milan K , Feng Mingxiao , Wang Junjiang , Fu Xiaomin , Akbar Razeen J , Bodnar Brittany H , Hu Wenhui , Wang Hong , Yang Xiaofeng , Yang Ling , Yang Peixin , Taib Bouchra , Ahima Rexford , Divall Sara , Wu Sheng 
Published: December 2023

Abstract
Hyperandrogenism and polycystic ovarian syndrome result from the imbalance or increase of androgen levels in females. Androgen receptor (AR) mediates the effects of androgens, and this study examines whether neuronal AR plays a role in reproduction under normal and increased androgen conditions in female mice. The neuron-specific AR knockout (KO) mouse (SynARKO) was generated from a female mouse (synapsin promoter driven Cre) and a male mouse (Ar fl/y). Puberty onset and the levels of reproductive hormones such as LH, FSH, testosterone, and estradiol were comparable between the control and the SynARKO mice. There were no differences in cyclicity and fertility between the control and SynARKO mice, with similar impairment in both groups on DHT treatment. Neuronal AR KO, as in this SynARKO mouse model, did not alleviate the infertility associated with DHT treatment. These studies suggest that neuronal AR KO neither altered reproductive function under physiological androgen levels, nor restored fertility under hyperandrogenic conditions.
Visual Hybrids and Nonconceptual Aesthetic Perception
Authors: Gal Michalle 
Published: December 2023

Abstract
This essay characterizes the perception of the visual hybrid as nonconceptual, introducing the terminology of nonconceptual content theory to aesthetics. The visual hybrid possesses a radical but nonetheless exemplary aesthetic composition and is well established in culture, art, and even design. The essay supplies a philosophical analysis of the results of cross-cultural experiments, showing that while categorization or conceptual hierarchization kicks in when the visual hybrids are juxtaposed with linguistic descriptions, no conceptual scheme takes effect when participants are presented with mere visual hybrids. In isolation, the hybrids do not lend themselves to classification.
I draw four conclusions from these experimental outcomes: The perception of visual hybrids follows the structure of a nonconceptual mental content, because the original categories or concepts of the hybrids’ components are not combined into one, and their properties are not applied to one another, therefore none of the components reconstructs the other such that it is introduced to a new category.Language freezes the hybridity of the visual hybrid into conceptuality.Given that language has a freezing effect in the case of an extreme visual phenomenon such as the hybrid, it is all the more restraining in moderate artistic compositions, such as visual metaphors, in which properties of one component (the source) are applied to the other (the target). In those, nonconceptuality emerges from relatively organized compositions, forms, and relations, and from the dependence of objects and their properties on perceptual context.Thus, the nonconceptualist terminology is suitable for the analysis of aesthetic perception in general and aesthetic perception's relation to language.
Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients
Authors: Siyal Mehreen , Abbas Zaigham , Amir Muhammad Rafay , Qadeer Muhammad Ali 
Published: December 2023

Background: Irritable Bowel Syndrome (IBS) leads to significant impairment of health-related quality of life, for the alleviation of which, the efficacy of available therapies is modest. Limited data is available on the role of Saccharomyces cerevisiae in treating patients with IBS.
Methods: Thirty patients with IBS as per Rome-IV criteria, visiting our outpatient department from March 2021 to October 2021, were given capsule Saccharomyces cerevisiae 500 mg twice daily for four weeks. Evaluation for abdominal pain symptoms was done every week and the patient’s compliance was assessed. IBS Quality of Life (QOL) questionnaires were filled at baseline and after four weeks of treatment. The QOL and pain scales were adjusted to 0-100 for statistical analysis.
Results: Seventeen patients (56.7%) were males. The age range was 21-72 years (mean ± SD: 39. 63 ± 14.32), out of which 18(60%) patients were 20-40 years old. Body Mass Index (BMI) ranged from 18-33 (25.33 ± 4.09), and 17 (56.67%) were overweight or obese. Sixteen patients had constipation predominant (53.3%), nine had diarrhea-predominant (30%), and five had mixed-type (16.7%) IBS. There was an improvement in the pain score from 63.81 at week 0 (W0) to 20.48 at the end of week 4 (W4) (p<0.001). An improvement was noted in all the eight categories of IBS QOL questionnaire, i.e., dysphoria (p<0.001), interference with activity (p<0.001), body image (p<0.001), health worry (p<0.001), food avoidance (p<0.001), social reaction (p<0.001), sexual function (p<0.001) and relationships (p<0.001). There was an overall improvement in QOL score from a mean of 24.68 at baseline to 58.09 at the end of the study duration (p<0.001). The improvement in the pain score showed a positive correlation with the improvement in quality of life (p<0.001).
Conclusion: Treatment with Saccharomyces cerevisiae improved the pain and quality of life in patients with IBS and it appears to be a promising option for alleviating symptoms in these patients.
doi: https://doi.org/10.12669/pjms.40.3.8349
How to cite this: Siyal M, Abbas Z, Amir MR, Qadeer MA. Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients. Pak J Med Sci. 2024;40(3):492-498. doi: https://doi.org/10.12669/pjms.40.3.8349
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pilot study of fractal dimension analysis of osteogenesis for bone substitute materials of Bio-Oss in lateral sinus augmentation
Authors: Wen Cai , Zhang Qing 
Published: December 2023

Background
Fractal dimension (FD) analysis has been proposed and validated in osseointegration-related research. The aim of this study was to evaluate the feasibility of FD analysis in the osteogenesis detection of bone substitute materials (BSMs) of Bio-Oss in maxillary lateral sinus augmentation.

Methods
Patients who received lateral maxillary sinus augmentation and underwent grafting with BSMs (Bio-Oss) were included in the study. The cross sections of the BSMs under cone-beam computed tomography (CBCT) at mesial, distal, and sagittal directions were obtained immediately after the graft (T0) and 6 months later (T1), and the obtained images were cropped to include only the BSMs. The FD analysis was performed, and the FD value was obtained by the method of box-counting. Paired t-tests and analysis of variance (ANOVA) were used, and p-values <0.05 was considered statistically significant.

Results
Twelve participants with 22 implants, which were inserted simultaneously after sinus augmentation, were included in this study. A total of 22 mesial, 22 distal, and 14 sagittal images were obtained after FD analysis. The mean FD value and standard deviation at T0 was 1.2860 ± 0.0896, while at T1, it was 1.2508±0.1023; thus, significant differences were detected (p = 0.022). However, the increasing or decreasing trend of FD value was not stable, and no significant difference was detected for FD values of mesial, distal, and sagittal images between T0 and T1. ANOVA indicated that no significant difference was detected among the FD values of mesial, distal, and sagittal images at any timepoint. Differences in FD values between the sexes were not significant either.

Conclusions
Since the FD analysis for the osteogenesis detection of BSMs in maxillary sinus augmentation indicated unstable trends of change, its feasibility is not reliable. The initially rough surface, self-degradation, and volume change of the BSMs during osteogenesis may be the reason for the variation in FD values.
Screening for the risk of canine impaction, what are the presumptive signs and how does it affect orthodontics? A cross-sectional study in France
Authors: Brézulier Damien , Carnet Steeven , Marie-Cousin Alexia , Sixou Jean-Louis 
Published: December 2023

Purpose
The treatment of impacted canines is a challenge for orthodontists. The availability of suggestive clinical signs has become crucial for treatment before the potential for evolution ceases. The main objective was to evaluate the prevalence of the suspected displaced canine (SDC) and to highlight factors easily identifiable from the oral examination.

Methods
SDC was assessed on panoramic X-rays, on the basis of the angle with the median sagittal plane and the degree of overlap with the permanent lateral incisor. Its association with mesio-distal tooth and palate widths was assessed by univariate analysis. Next, the association of SDC with temporary tooth extraction, expansion and/or premolar extraction was considered using the same modality.

Results
In this retrospective study, the records of 292 patients aged 7 to 13 years were reviewed. SDC was detected in 39% of patients i.e., 28,8% of observed canines. Reduced coronal mesio-distal diameters of permanent maxillary central incisors, 8.7 ± 0.6 mm versus 8.8 ± 0.7 mm (p < .05), and first permanent molars, 10.0 ± 0.7 mm versus 10.2 ± 0.7 mm (p < .001), as well as reduced inter-molar width, 38.7 ± 2.7 mm versus 39.4 ± 2.9 mm (p < .01), were predictive factors. SDC led orthodontists to indicate extraction of maxillary primary canines, OR = 3,32 (p < .001) or even extraction of premolars, OR = 1,66 (p < .05).

Conclusion
This study confirmed the interest of panoramic X-rays in detected canines at risk of SDC. Dental factors can be combined to make screening more reliable and predict impaction that makes orthodontics complex.

Trial registration number
Opinion n°21.131, dated 09.21.2021, retrospectively registered.
Pengaruh Situation Awareness terhadap Peningkatan Task Performance Bidan Desa
Authors: Uktutias Sendy Ayu Mitra , Hadi Cholichul 
Published: December 2023

The strategy to reduce the high infant mortality rate (IMR) is by placing midwives in the village. One of the tasks of village midwives is the prevention of complications through early detection, which is indicated by the performance of midwives based on neonatal coverage. Situation awareness is an important component of decision making that has a significant impact on the performance of the village midwife's duties, so the purpose of this study was to analyze the effect of the role of situation awareness on the performance of the village midwife's duties in detecting problems in young infants. Quantitative research was designed using a cross sectional study. All village midwives became the population and were determined based on the results of a sample calculation of 151 village midwives who would be taken proportionally. The research variables were situation awareness and task performance. The instrument used a questionnaire and analyzed using Simple Linear Regression. The results explained that the consistent value of task performance was 43.041. B situation awareness value (regression coefficient) 0.917. The regression coefficient is positive that the direction of the influence of situation awareness on task performance is positive. Decision making in simple linear regression is 0.000 <0.05 with the t value showing 8.256> from the t table of 1.97, which means that situation awareness has an influence on the performance of the village midwife's duties. Situation awareness is a predictor that is able to influence task performance for village midwives in providing care to neonates in early detection of problems in young infants.
Monitoring drought dynamics using remote sensing-based combined drought index in Ergene Basin, Türkiye
Authors: Gümüş Kerim Aykut , Balçık Filiz Bektaş , Esetlili Tolga , Kahya Ceyhan 
Published: December 2023

Abstract
Remote sensing-based approaches have gained widespread usage in drought monitoring studies. However, relying on single-variable drought indices may be inadequate to provide a comprehensive understanding of drought dynamics. In this study, principal component analysis was employed to derive a combined index, namely, the combined drought index (CDI), from multiple indices such as vegetation condition index, temperature condition index, precipitation condition index, and soil moisture condition index. The CDI was subsequently employed to analyze drought occurrences in the Ergene Basin-Türkiye period from 2001 to 2020 (May to October) using MODIS data. Correlations were computed with standardized precipitation index (SPI) and standardized precipitation evapotranspiration index (SPEI) at 1-, 3-, and 6-month scales and crop yield. The results revealed that drought incidents transpired in the Ergene Basin for at least 1 month annually. May exhibited the wettest, while September stood as the driest month. The severity of drought and its spatial extent displayed an increasing trend followed by a subsequent decline during the aforementioned period. The CDI demonstrated stronger correlations with the 1-month standardized indices than the 3- and 6-month SPI-SPEI. A robust correlation of 0.79 was also observed between the CDI and the crop yield. In general, the CDI performed well in determining the spatial and temporal patterns of the historic droughts. As a result, the CDI could be leveraged to develop effective drought monitoring and management, which could help mitigate the negative impact of drought in the fragile environment of the Ergene Basin.
Anticancer and antimicrobial potential of zinc/sodium alginate/polyethylene glycol/d-pinitol nanocomposites against osteosarcoma MG-63 cells
Authors: Lakshmanan Anandaraj , Govindasamy Chandramohan , Sivakumar Allur Subramaniyan , Hussein-Al-Ali Samer Hasan , Ramesh Monishsanthosh , Lakshmanan Hariprasath 
Published: December 2023

Abstract

Background
The field of nanomedicine has attracted much interest and is now serving as the impetus for many revolutionary advances in the pharmaceutical industry.

Objectives
In the current exploration, we intended to fabricate the zinc/sodium alginate/polyethylene glycol/d-pinitol nanocomposites (ZSP/D-Pin/NCs) and evaluate their antimicrobial and anticancer properties against MG-63 cells.

Methods
ZSP/D-Pin/NCs were synthesized and characterized using several techniques and their cytotoxicity was examined against osteosarcoma MG-63 cells and normal 3T3 cells using the MTT assay. The levels of oxidative stress and apoptotic protein were examined using assay kits and fluorescence staining.

Results and Conclusion
The findings of several characterization studies revealed the development of agglomerated and crystalline ZSP/D-Pin/NCs. The antimicrobial assay demonstrated that ZSP/D-Pin/NCs substantially inhibited the growth of pathogens. Additionally, the MG-63 cell viability, which was exposed to several doses (1–20 µg) of ZSP/D-Pin/NCs, showed a remarkable decrease at various time periods, i.e., 24, 48, and 72 h without showing toxicity in 3T3 cells. The results of the fluorescence staining assay demonstrated that ZSP/D-Pin/NCs considerably increased apoptosis in the MG-63 cells by triggering oxidative stress. The antioxidants were reduced and upregulated the Bax and caspase expressions in ZSP/D-Pin/NC-treated MG-63 cells.
In-field calibration of triaxial accelerometer based on PE-ANGO
Authors: Qiao Meiying , Yao Wenhao , Gao Kefei , Du Heng , Zhao Kaidong 
Published: December 2023

Abstract
This paper presents a new method for in-field calibration of accelerometers to address the problems of low efficiency and high cost associated with traditional calibration methods. A nonlinear mathematical model of the accelerometer is established, and the cost function is analysed and deduced the cost function. Then, an adaptive Northern Goshawk Optimisation (NGO) algorithm based on prior knowledge enhancement is introduced. A method of collecting multi-position data with a hand-held accelerometer is introduced, and the proposed algorithm is used to in-field calibrate nine parameters of the accelerometer’s nonlinear error model. In addition, simulation is used to compare the results of calibrating the accelerometer using the proposed algorithm and the original algorithm, demonstrating the superiority of the proposed algorithm. Finally, experimental results confirm that the proposed method can rapidly calibrate accelerometer error parameters without relying on complex equipment and with greater accuracy than traditional methods.
Izražavanje emocije sreće u hrvatskim i talijanskim frazemima
Authors: Mušac Vini 
Published: December 2023

U ovome radu istražit će se način izražavanja sreće u hrvatskoj i talijanskoj frazeologiji i utvrditi postoje li podudarnosti u dvama jezicima s obzirom na plan izraza i na pozadinsku sliku frazema. S jedne strane frazeološka će raščlamba biti osnovana na frazemima čija je jedna od sastavnica sreća (biti lud od sreće) i tal. gioia (essere pazzo di gioia) i njezini sinonimi ili djelomični sinonimi kao što su radost, veselje, fortuna i sl. u hrvatskome, odnosno felicità, allegria, fortuna i sl. u talijanskome te leksemi čije značenje upućuje na druge emocije povezane sa srećom kao što su zadovoljstvo, tal. contentezza. S druge strane analiza će se temeljiti na somatskim frazemima iz čijega se značenjskoga plana iščitava emocija sreće (imati osmijeh od uha do uha i avere un sorriso da un orecchio all'altro). S treće strane analiza će se temeljiti na nesomatskim frazemima čija pozadinska slika upućuje na emociju sreće (biti u sedmome (devetome) nebu i essere al settimo cielo). U radu se pokazuje da se frazeološki korpus dvaju jezika u velikoj mjeri podudara na planu izraza i sadržaja, ali i da svaki od korpusa sadrži specifičnosti koji su odraz kulture, nataloženoga zajedničkog narodnog iskustva i pogleda na svijet.
Synthesis and Characterization of Bioplastic from Macroalgae Padina australis
Authors: Putri Lily Surayya Eka , Saridewi Nanda , Farah Sabrina 
Published: December 2023

Synthetic plastics are one of the more significant contributors to waste in the environment. Bioplastic is a type of plastic that is environmentally friendly because it is made from biomass. In this study. brown macroalgae. Padina australis. is one of the potential raw materials found in large quantities in Indonesian waters and used to produce bioplastics with filtration technique. The aim of this study was to synthesis bioplastics using P. australis alginate with glycerol plasticizer.The alginate macroalgae were mixed with glycerol as a plasticizer in the following proportions: 1:15. 1:25. 2:15. and 2:25. with the quality determined through tensile strength measurements. water solubility. and degradation time. On day 12. the tensile strength of P. australis bioplastic was 3.24-7.33 MPa. the water solubility was 61.79-65.19%. and the biodegradability rate was 0.1-20.0%. When the macroalgae alginate and glycerol formulation was 2:25. the best bioplastic film produced had a tensile strength of 7.33 MPa and a water solubility of 61.79%. which was lower than the Indonesia National Standard number 7818/2016 for bioplastic products. P. australis. however. has the potential to be a promising alternative bioplastic product that contributes to the reduction of petroleum-based plastic pollution in the environment. Furthermore. as a preliminary study. it will be improved to meet industrial standards or find the products that match these characteristics.
The Potential Effect of Honey-derived D-Allulose in Counteracting Hyperglycemia by Time and Dose Dependent Manner in Diabetes Mellitus
Authors: Sari Flori R. 
Published: December 2023

Diabetes mellitus has become a worldwide burden due to its persistent, chronic hyperglycemia. D-allulose, a monosaccharide sugar with a 180.16 molecular weight, is widely used as a low-calorie sweetener, is not involved in glucose-related metabolism, and thus does not alter insulin and pancreatic function. This study aimed to evaluate the potential role of honey-derived D-allulose in acute and sub-chronic diabetes mellitus. Diabetic Sprague-Dawley rats were divided into 9 groups and treated with 0.1, 0.2, and 0.4 g/kg BW honey-derived D-allulose for 28, 56, and 84 days. Post-prandial blood glucose levels and body weight were measured every 4 weeks. Significant reductions in post-prandial blood glucose levels were observed on days 56 and 84 treatment with 0.1 g/kg BW D-allulose. More significant reductions were observed on days 28, 56, and 84 of treatment with 0.2 or 0.4 g/kg BW D-allulose. Eighty-four days of treatment with 0.4 g/kg BW D-allulose significantly reduced post-prandial blood glucose levels compared to all groups. We identified that honey-derived D-allulose reduced post-prandial blood glucose levels in a dose- and time-dependent manner. Thus, honey-derived D-allulose may provide beneficial support for diabetic conditions not only as a sweetener but also as a pharmacological treatment.
Developing the optimal chemical composition of heat-resistant Cr-Ni steel for aerospace equipment
Authors: Mishchenko Valeriy , Kripak Alona , Tonkonoh Dmytro 
Published: December 2023

The object of research in this work is the processes of forming the microstructure and mechanical properties of heat-resistant steels depending on their chemical composition.
The microstructure and high-temperature mechanical properties of austenitic heat-resistant chrome-nickel steels of the proposed chemical composition were investigated in the work. The microstructure study determined the grain size and topography of inclusions in steels. Based on the results of mechanical tests, a multifactorial experiment was planned, which made it possible to establish the relationship between the mechanical properties of steels with alloying elements selected as factors. The obtained regression equations were used to estimate the quantitative influence of each alloying element on the corresponding mechanical properties.
Analysis of the results of the experiment made it possible to determine the optimal chemical composition of steel for gas turbine engines used in the aerospace industry, as well as in the metallurgy of titanium production.
It is shown that the state of solid solution and heat-resistant niobium and molybdenum carbides (chromium carbides dissolve at a temperature of 950 °C) are an important factor that significantly affects the structure, mechanical, and service properties of heat-resistant steel. The austenite structure is provided by the required amount of nickel.
The resulting indicators of heat resistance of steels of different compositions, tested at temperatures of 850 °C, 950 °C, and 1050 °C, proved the superiority of steel with a higher content of carbon and chromium and a lower content of nickel.
The mechanism of steel strengthening and the influence of alloying with carbon, chromium, and nickel on it have been determined. The optimal chemical composition of heat-resistant steel on an iron-nickel basis for operation at a temperature of 950 °C has been established