bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of pneumonia indexes associated with mechanical ventilation in a COVID-19 unit with dentist
Authors: Feitosa Alinne , Veras Pedryna , Sampaio Eliane , Filho Edson Cetira , Matos Ylana , Carvalho Aristea 
Published: November 2023

Abstract

Objective:The aim of this research is to evaluate whether there was a difference after the insertion of the dental surgeon in an Intensive Care Unit (ICU) that cares for patients with COVID-19 in relation to VAP control, length of stay and mortality.Materials and methodsThe dentist was added to the multidisciplinary team for three months. A training session with the nurses and nursing technicians was held at the start of every month. The Hospital Infection Control Service gathered data on VAP, hospital stay length, and ICU mortality in the three months before and three months after the dentist joined the team.Results:After statistical analysis, the hospitalization rate increased in the period in which the dentist was working in the COVID-19 unit, but the p value was not significant in this variant (p > 0.062). The percentage of VAP in the period before and after the dentist's intervention in the COVID-19 unit decreased with a significant difference between the evaluated periods (p < 0.0001). Regarding mortality, it was found that there was an increase in the number of deaths over time, however without statistical significance (p > 0.2790).ConclusionThe pandemic came to confirm the importance of dental care in the hospital environment and the integration of the professional dentist in the health team, contributing to the oral health and quality of life of critical patients.Clinical significance:As a contribution to clinical practice, our study shows that the increase in the number of dentists in the multidisciplinary teams, providing training and support to the team with oral care in critically ill patients, together with the fixed protocol on hygiene in intubated patients passed on to the team at the beginning of each month, added to her interest in learning correctly, contributed significantly to the reduction of VAP.
Catechol-Conjugated Alginate Biopolymer for Eco-Friendly Synthesis of Gold Nanoparticles: A Promising Approach for Photothermal and Radiotherapy in Breast Cancer Treatment
Authors: Ghaffarlou Mohammadreza , Rashidzadeh Hamid , Mohammadi Ali , Mousazadeh Navid , Barsbay Murat , Sharafi Ali , Gharbavi Mahmoud , Danafar Hossein , Javani Siamak 
Published: November 2023

Abstract
Radiation therapy and phototherapy are commonly used treatments for cancer that offer advantages such as a low risk of adverse effects and the ability to target cancer cells while sparing healthy tissue. A promising strategy for cancer treatment involves using nanoparticles (NPs) in combination with radiation and photothermal therapy to target cancer cells and improve treatment efficacy. The synthesis of gold NPs (AuNPs) for use in biomedical applications has traditionally involved toxic reducing agents. Here we harnessed dopamine (DA)-conjugated alginate (Alg) for the facile and green synthesis of Au NPs (Au@Alg-DA NPs). Alg-DA conjugate reduced Au ions, simultaneously stabilized the resulting AuNPs and prevent aggregation, resulting in particles with a narrow size distribution and improved stability. Injectable Au@Alg-DA NPs significantly promoted ROS generation in 4T1 breast cancer cells when exposed to X-rays. In addition, their administration raised the temperature under a light excitation of 808 nm, thus helping to destroy cancer cells more effectively. Importantly, no substantial cytotoxicity was detected in our Au@Alg-DA NPs. Taken together, our work provides a promising route to obtain an injectable combined radioenhancer and photothermally active nanosystem for further potential clinic translation.
Hydroxytyrosol, a component of olive oil for breast cancer prevention in women at high risk of cancer
Authors: Puri Akshjot , Yin Zheng , Granados-Principal Sergio , Ensor Joe , Guzman Liliana , Rosato Roberto , Zhao Hong , Wong Stephen , Wang Lin , Patel Tejal , Chang Jenny 
Published: November 2023

Abstract
Background
This study evaluates the effects of hydroxytyrosol (HT), a component of olive oil, on mammographic breast density reduction. We explored effects of HT on Wnt β-catenin and other pathways involved in cancer stem cell renewal, DNA repair, cell proliferation and differentiation.
Methods
25mg/day oral dose of HT were given for 12 months in pre- and post-menopausal women at increased risk of breast cancer. Out of 51 patients enrolled, 41 completed the study. The annualized percent decrease in maximum mammographic volumetric breast density (Max VBD%) between baseline (BL) and end-of-treatment (EOT) was analyzed. RNA sequencing (RNA-Seq) and multiplex analysis was performed on the breast biopsies to compare the BL with EOT samples.
Results
Max VBD% showed a non-significant change; however, in women 60 years or older, the max VBD% decrease was significant (3.7%, p=0.0391), especially in those with high baseline mammographic density. Using RNA-Seq, 3,330 unique transcripts were identified (p<0.05). Mitotic telophase/cytokinesis, DNA damage were upregulated, whereas Wnt, Notch, and Oxidative stress-induced senescence pathways were downregulated (p<0.05). These pathways were confirmed by Nano string n counts where significant decrease in proliferative genes (RELA and CDK4), Wnt pathway (R-HSA-195721 and R-HAS-201681) were observed (p< 0.05).
Conclusions
Hydroxytyrosol significantly reduced breast density only in women over 60 years, especially in those with high baseline breast density. HT also reduced proliferation and affected Wnt signaling pathway. This study lays the foundation for future larger studies in exploring a natural compound with well tolerability and overall nontoxic profile for chemoprevention of breast cancer.
The effect of behavioral activation play therapy in adolescents with depression: a study protocol for a randomized controlled trial
Authors: Huang Xiaolong , Chen Yuqi , Luo Jiacheng , Luo Wei , Wang Dongdong , Yang Chanjuan , Zhou Yanling 
Published: November 2023

Abstract

Background
Depression is a common psychological problem in adolescents worldwide. Although the World Health Organization recommends physical activity to reduce depressive symptoms in this population, compliance with this recommendation is often low. Furthermore, although behavioral activation therapy (BAT) is recommended as a treatment for adolescents with depression, the reported effect size is small. Compared with traditional exercises, gamified physical activities (GPA) can be particularly appealing to adolescents because they are considered to be enjoyable experiences. Thereby, they often have good uptake in adolescent populations. In this study, we integrated BAT and GPA to create behavioral activation play therapy (BAPT). We designed a clinical trial to investigate the feasibility, acceptability, and effectiveness of this treatment in adolescents with depression.
Methods
The study is a randomized controlled trial (RCT) with a single-blind, two-arm design, conducted to validate the effectiveness and applicability of BAPT for adolescent depression. On the basis of conventional treatment and care, we will compare the outcomes of BAPT and BAT. The intervention group and control group will receive nine sessions of BAPT or BAT, respectively. The number of adolescents recruited will be 200, with a 1:1 distribution ratio.
Discussion
This is the first RCT to explore the effectiveness and adaptability of BAPT in adolescents with depression. This study will provide evidence that may help to decrease depressive symptoms in adolescents, and will demonstrate the treatment effectiveness in terms of increasing levels of physical activity, reducing the rate of non-suicidal self-injury behaviors, and improving sleep quality. We also hope to assess other possible clinical effects of BAPT.
Trial registration:
Chinese Clinical Trial Register Center, ChiCTR2300072671. Registered on 20 June 2023.
The value of HIFI model based on cell-free DNA genomic features in early diagnosis and prediction of hepatocellular carcinoma
Authors: Li Linhan , Lu Xiaobo , Wang Xiaozhong , An Xuan , Zhang Quan , Hu Peng , Cai Dachuan , Lan Yinghua , Zhang Dazhi , Kang Juan 
Published: November 2023

Abstract
Background The detection of cell-free DNA (cfDNA) is a promising early diagnosis method for hepatocellular carcinoma (HCC). We validated the cfDNA-based comprehensive diagnostic model (HIFI) and explored its value in the early diagnosis and prediction of HCC.
Methods cfDNA detection was performed in 126 patients, the results of HIFI were obtainedand compared with HCC markers. Moreover, we conducted a comparison between the predictive ability of aMAP score and the HIFI model for HCC at 10 months of follow-up.
Results Chi-square test and Kappa analysis showed that the diagnostic consistency between HIFI model and traditional methods was significantly higher than that of AFP and PIVKA-II (Kappa=0.461 vs 0.251 vs 0.287, P≤0.05). Moreover, the consistency of HIFI model combined with PIVKA-II was higher than that of AFP combined with PIVKA-II and HIFI model combined with AFP (Kappa=0.564 vs 0.267 vs 0.317, P≤0.05). We compared HIFI model with aMAP score at 10 months, the sensitivity, specificity, PPV and NPV of HIFI model in predicting HCC was 70.59%, 90.32%, 66.67% and 91.80%. When 50/60 is set as the cut-off value of aMAP score, the sensitivity, specificity, PPV and NPV was 94.12 / 76.47%, 29.03 / 72.58%, 26.67 / 43.33% and 94.74 / 91.84%.
Conclusions The study demonstrated the superiority of the cfDNA-based HIFI model as a method of early warning and diagnosis of HCC. Moreover, the predictive efficacy of the HIFI model remained high at 10 months, in terms of specificity and PPV, the HIFI model was better than aMAP score.
Juvenile Eosinophilic Fasciitis: A Single Center Case Series
Authors: Stubbs Leigh Anna , Ogunbona Oluwaseun , Beil Emily , Szafron Vibha , Adesina Adekunle , Anvari Sara , Lai Jamie , Ramirez Andrea , Ditzler Matthew , De Guzman Marietta 
Published: November 2023

Abstract

Background:Eosinophilic fasciitis (EF) is a rare disease characterized by skin induration and musculoskeletal abnormalities. Diagnostic criteria for EF are based on adult populations. There is a need to expand the literature on EF in children due to limited reported cases and potential differences compared to adults.Methods:We conducted a retrospective review of medical records for six pediatric patients diagnosed with EF at our institution between November 2011 and April 2023. Inclusion criteria required patients to be under 18 years of age at the time of diagnosis and to have confirmed diagnosis through clinical history, imaging, and histology.Results:Most of our cohort were female (83%) and non-Hispanic white (50%). Age at diagnosis ranged from 4 to 16 years. Duration of symptoms before diagnosis varied from 1 to 12 months. Follow-up periods ranged from 14 to 123 months. Concurrent medical conditions included localized scleroderma, acquired thrombophilia, and juvenile idiopathic arthritis. Patients presented with progressive painful swelling, severe joint limitations, and positive prayer sign. Initial regimens involved corticosteroids and methotrexate. Hydroxychloroquine, immunoglobulin, mycophenolate mofetil, rituximab, and tocilizumab were also used depending on the patient’s disease severity and course.Conclusions:Juvenile EF may manifest as swelling and progressive induration without apparent skin abnormalities. Unlike adult populations, no underlying malignancies or associations with trauma were observed in our cohort. Our cases did not exhibit systemic involvement observed in previous studies on juvenile EF. While non-specific, the prayer sign may aid in early recognition of juvenile EF and help prevent long-term disability.
Cooperative control for multi-player pursuit-evasion games embedded on communication technology with reinforcement learning
Authors: kavin Balasubramanian Prabhu , K Aravinda , Kamala Praveena Rachel , E Naresh , Pareek Piyush Kumar 
Published: November 2023

Abstract

Recent advances in research on the Multi-agent System (MAS) optimal control issue will help sectors like robotics, communications, and power systems. This work looks at the intelligent design of a large-scale multi-pursuer and multi-evader pursuit-evasion game. Based on reinforcement learning, a distributed cooperative pursuit method with communication is created. The famed Curse of Dimensionality poses a serious danger to multi-player pursuit-evasion game designs due to the sheer number of agents, especially in hostile areas where there aren't many communication options available to encourage player information exchange. In order to find the best pursuit-evasion strategies using a novel type of probability density function (PDF) rather than exhaustive data from all the remaining teams or agents, the Mean Field Games (MFG) theory has been used. A novel MAS optimum type oversight system with a decentralised and computer-friendly decision method is urgently needed. Mean field game theory is used to create the Actor-critic-mass (ACM), a decentralised optimal control system, to address the aforementioned issues. Additionally, the homogeneous decentralised Actor-critic-mass (HDACM) which improves the ACM method, does away with restrictions like homogeneous agents and cost functions. Finally, two applications make use of the PAS algorithm.
A meta-analysis of differentially expressed microRNA during mastitis disease in dairy cattle
Authors: Panahi bahman , hasanpour karim , ghahramani nooshin , rafat abbas , shodja jalil 
Published: November 2023

Abstract

Background:Bovine mastitis is an important inflammation disease that affects the mammary gland and causing adverse effects on the quality and quantity of the produced milk, leads to a major economic lost in dairy industry.Streptococcus uberisis one of the bacteria commonly responsible for inducing mastitis in dairy cattle. Susceptibility to develop mastitis is a complex multifactorial phenotype and the improvement of the miRNAs and their target genes has not been comprehensively illustrated.Methods and Results:The purpose of this investigation was to perform a meta-analysis of the miRNAs expression profiling datasets to detect the key miRNAs, targets, and regulatory networks associated with mastitis. To this, publicly available miRNA datasets belong to three experiments on dairy cattle which challenged withS. uberiswere included in our meta-analyzed. The identified differentially expressed miRNAs were used in TargetScan to identify their target genes. The functional impacts of the meta-miRNAs were further analyzed using Gene ontology and Protein-Protein Interaction network analysis. Three meta-miRNAs, namely bta-miR-98, bta-miR-138 and bta-miR-193a-3p, were obtained to be associated with the progress of the immune system and cell differentiation of the mammary gland during the mastitis. A total of 2061 target genes were identified that which bta-miR-98, bta-miR-138 and bta-miR-193a-3p were regulated 1121, 268 and 672 target genes respectively. Gene ontology analysis results were represented 237 biological process, 41 molecular function, 54 cellular component roles and nine KEGG pathways in mastitis disease. A total of 319, 113 and 124 target genes for bta-miR-98, bta-miR-193a-3p and bta-miR-138, respectively were inputted to cytoscape. The resulted network analysis showed that bta-miR-98 and bta-miR-138 have nine, bta-miR-138 and bta-miR-193a-3p have six, and bta-miR-193a-3p and bta-miR-98 have four common target genes. Twenty-one common genes were revealed by combing 360 common meta-genes in our previous research and 2061 meta-miRNA target genes. The procedure reported in this research offers a comprehensive scheme for the identification of the key miRNAs and target genes in mastitis disease by using global transcriptome data, meta-analysis, gene ontology, enrichment analysis and protein protein interaction.Conclusion:The findings of the current work suggest miRNAs are crucial amplifiers of inflammatory response by controlling metabolic pathway and inhibitors of several biological processes duringS. uberisinfection.
Neoadjuvant Stereotactic Ablative Body Radiotherapy Combined with Surgical Treatment for Renal Cell Carcinoma and Inferior Vena Cava Tumor Thrombus: A Prospective Pilot Study
Authors: Chen Jiyuan , Liu Zhuo , Peng Ran , Liu Yunchong , Zhang Hongxian , Wang Guoliang , Tian Xiaojun , Pei Xinlong , Wang Junjie , Zhang Shudong , Wang Hao , Ma Lulin 
Published: November 2023

Abstract
Background
Surgical treatment for renal cell carcinoma (RCC) and inferior vena cava (IVC) tumor thrombus (TT) is difficult and has a high postoperative complication rate. This study aims to explore the safety and oncologic outcomes of neoadjuvant stereotactic ablative body radiotherapy (SABR) combined with surgical treatment for RCC and IVC-TT.
Methods
Patients with RCC and IVC-TT were enrolled in this study. All of them received neoadjuvant SABR focused on IVC at a dose of 30 Gy with 5 fractions, followed by 2 ~ 4 weeks of rest. Then, radical nephrectomy and IVC tumor thrombectomy were performed on each patient. Adverse effects, perioperative outcomes, and long-term prognosis were recorded.
Results
From June 2018 to January 2019, 8 patients were enrolled, including 4 with Mayo II TT and 4 with Mayo III TT. 4 (50%) patients had complicated IVC wall invasion according to CT/MRI. All patients received neoadjuvant SABR as planned. Short-term local controls were observed in all 8 cases. Only grade 1–2 adverse events were reported. In total, 3 (37.5%) laparoscopic surgeries and 5 (62.5%) open surgeries were performed. The median operation time was 359 (IQR: 279–446) min, with a median intraoperative bleeding volume of 750 (IQR: 275–2175) ml. The median postoperative hospital stay was 7 (5–10) days. With a 26 (range: 5–41) month follow-up period, the estimated mean overall survival was 30.67 ± 5.38 months.
Conclusions
As the first preoperative radiotherapy study in Asia that focused on TT, this study revealed the appreciable safety of neoadjuvant SABR for RCC with IVC-TT.
Trial Registration
This study was registered in Chinese Clinical Trials Registry in 2018-03-08 (ChiCTR1800015118). For more information, please see the direct link (https://www.chictr.org.cn/showproj.html?proj=25747).
Nomogram predicting the cardiovascular disease mortality for the older patients with colorectal cancer: a population-based study reflecting the real world
Authors: Tan Jiayu , Shen Shuohao 
Published: November 2023

Abstract

Introduction: Cardio-oncology has received more and more attention in the older patients with colorectal cancer(CRC). We aimed to identify the prognostic factors and construct a nomogram-based model to predict the cardiovascular disease(CVD) mortality for the older patients with CRC.Materials and Methods: The data on the older patients diagnosed with CRC were retrieved from the SEER database from 2004 to 2015. The prognostic factors and a nomogram-based model predicting the CVD-specific mortality was performed by the Least absolute shrinkage and selection operator (LASSO) and Cox regression.Results: A total of 141251 eligible patients with CRC were enrolled, of which 41459 patients died of CRC and 12651 patients died of CVD. The age at diagnosis, sex, marital status, the year of diagnosis, surgery and chemotherapy were independent prognostic factors associated with CVD-specific mortality in the older patients with CRC. And we used these variables to develop the model predicting the CVD-specific mortality. The calibration curves for CVD-specific mortality probabilities showed that the model was in good agreement with actual observations. The C-index value of the model in the training cohort and testing cohort for predicting CVD-specific mortality was 0.728 and 0.734, respectively.Discussion: The proposed nomogram-based model of the CVD-specific mortality could be used to predict the accurate prognosis for the older patients with CRC. This model could be a useful tool for clinicians to identify high-risk patients and develop personalized treatment plans. The derived nomogram-based model could be adopted to assistant clinicians including oncologists and cardiologists to providing screening recommendations and choosing an optimum treatment regimen.
Temporal and spatial evolution of ecosystem services value in Hefei city based on land use change, and multi-scenario prediction
Authors: Lu Zhipeng , Dong Bin , Xu Zhili , Wang Cheng , Wei Zezhu , Liu Xiao 
Published: November 2023

Abstract
Ecosystem service value (ESV) is an important index to measure regional ecological well-being, and its spatio-temporal evolution is of great reference significance for promoting the comprehensive green transformation of economic and social development. Based on the change law of land use and ecosystem service value in Hefei City from 2000 to 2020, this paper uses FLUS model and ecosystem service value (ESV) evaluation method to simulate the ecosystem service value of Hefei City in 2040 under four scenarios of natural development, cropland protection, urban development and ecological protection, so as to explore the impact of future land use change on ecosystem service value. The results show that: (1) From 2000 to 2020, the area of cropland in Hefei City continued to decrease, the area of construction land and grassland increased significantly, and the area of other land types changed little. (2) From 2000 to 2020, the total value of ESV in Hefei increased first and then decreased. The total value of ESV increased significantly from 2000 to 2010, and the total value of ESV decreased by 703.75 CNY billion from 2010 to 2020. (3) Under the multi-scenario simulation, the ESV values of Hefei City in 2040 under urban development and cropland protection have different degrees of loss, but the ESV under the natural development and ecological protection scenarios not only did not decrease but increased by CNY 1.5358 and CNY 8.0757 billion respectively. Among the four scenarios, the most ESV loss was the urban development scenario, with a total reduction of CNY 117.52 billion. The research results can provide a scientific basis for the optimization of land use structure and the establishment of a long-term mechanism for ecological protection and restoration in Hefei in the future.