bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letrozole-stimulated endometrial preparation protocol is a superior alternative to hormone replacement treatment for frozen embryo transfer in women with polycystic ovary syndrome, a cohort study
Authors: Wang Xiaojuan , Li Yuan , Tan Hongzhuan , Cai Sufen , Ma Shujuan , Peng Yangqin , Guo Hui , Li Xiaofeng , Tang Yi , Zhang Shunji , Lin Ge , Gong Fei 
Published: October 2023

Abstract
Background
The current routine endometrial preparation protocol for women with polycystic ovary syndrome (PCOS) is hormone replacement treatment (HRT). Letrozole is rarely used in frozen embryo cycles. Evidence confirming whether letrozole-stimulated (LS) protocol is suitable for frozen embryo transfer in patients with PCOS and for whom is suitable remains lacking.

Methods
This was a retrospective cohort study involving all frozen embryo transfer cycles with LS and HRT for PCOS during the period from Jan 2019 to December 2020 at a tertiary care center. Multivariate Logistic regression was used to analyze the differences in clinical pregnancy rate, live birth rate, miscarriage rate, the incidence of other pregnancy and obstetric outcomes between LS and HRT protocols after adjusting for possible confounding factors. Subgroup analysis was used to explore the population for which LS protocol was suitable.

Results
The results of multivariate logistic regression showed that LS was significantly associated with a higher clinical pregnancy rate (70.9% vs. 64.4%;aOR:1.41, 95%CI: 1.18,1.68), live birth rate (60.5% vs. 51.4% aOR:1.49, 95%CI: 1.27,1.76), and a lower risk of miscarriage (14.7% vs. 20.1% aOR: 0.68, 95%CI: 0.53,0.89), hypertensive disorders of pregnancy (6.7% vs. 8.9% aOR: 0.63, 95%CI: 0.42,0.95), and gestational diabetes mellitus (16.7% vs. 20.7% aOR:0.71, 95%CI: 0.53,0.93) than HRT. There were no significant differences in other outcomes such as preterm birth, cesarean delivery, small for gestational age, or large for gestational age between the two endometrial preparation protocols. Subgroup analysis showed that LS had higher live birth rates than HRT in most of the subgroups; in the three subgroups of maternal age ≥ 35 years, menstrual cycle < 35 days, and no insulin resistance, the live birth rates of the two endometrial preparation protocols were comparable.

Conclusions
LS protocol could improve the live birth rate and reduce the incidence of miscarriage, hypertensive disorders of pregnancy and gestational diabetes mellitus in patients with PCOS. LS protocol is suitable for all types of patients with PCOS. LS should be considered the preferred endometrial preparation protocol for women with PCOS.
Adherence to treatment and parents’ perspective about effectiveness of melatonin in children with autism spectrum disorder and sleep disturbances
Authors: Sadeh Hadar , Meiri Gal , Zigdon Dikla , Ilan Michal , Faroy Michal , Michaelovski Analya , Sadaka Yair , Dinstein Ilan , Menashe Idan 
Published: October 2023

Abstract
Objective
Melatonin is considered an effective pharmacological treatment for the sleep disturbances that are reported in > 50% of children with autism spectrum disorder (ASD). However, real-life data about the long-term course and effectiveness of melatonin treatment in children with ASD is lacking.

Methods
In this retrospective cohort study, we assessed the adherence to melatonin treatment and parents’ perspective of its effect on sleep quality and daytime behavior in children with ASD via a parental phone survey of children in the Azrieli National Center for Autism and Neurodevelopment Research (ANCAN) database. Cox regression analysis was used to assess the effect of key demographic and clinical characteristics on treatment adherence.

Results
Melatonin was recommended for ~ 8% of children in the ANCAN database. These children were characterized by more severe symptoms of autism. The median adherence time for melatonin treatment exceeded 88 months, with the most common reason for discontinuation being a lack of effectiveness (14%). Mild side-effects were reported in 14% of children, and 86%, 54%, and 45% experienced improvements in sleep onset, sleep duration and night awakenings, respectively. Notably, melatonin also improved the daytime behaviors of > 28% of the children. Adherence to treatment was independently associated with improvements in night awakenings and educational functioning (aHR = 0.142, 95%CI = 0.036–0.565; and aHR = 0.195, 95%CI = 0.047–0.806, respectively).

Conclusions
Based on parents’ report, melatonin is a safe and effective treatment that improves both sleep difficulties and daily behavior of children with ASD.
The mediation role of resilience and postpartum traumatic stress disorder on parental attachment and the maternal-infant bonding
Authors: Nie Rong , Pan Mengxia , Liu Xinwen 
Published: October 2023

Abstract
Aims
This study aimed to evaluate the correlation between parental attachment, resilience, postpartum traumatic stress disorder (PTSD), and maternal-infant bonding at 1 to 3 months postpartum. The mediation effect of resilience and PTSD on the postpartum parental attachment and maternal-infant bond was also evaluated.

Design
A cross-sectional research design was used.

Methods
A total of 400 postpartum women examined at a tertiary hospital in Wuhan from January 2021 to June 2021 were enrolled in the study. At about 1 to 3 months after giving birth, the women were asked to complete the Postpartum Bonding Questionnaire (PBQ), Connor-Davidson Resilience scale(CD-RISC), PTSD CheckList-Civilian version (PCL-C), and the Parental Bonding Instrument (PBI). The data were summarized using descriptive statistics. Mediation analyse and the Spearman correlation (r) were used to correlate the resilience and PTSD questionnaire scores.

Results
The care attachment dimension was significantly associated with resilience (r = 0.24, p < 0.01), PTSD (r = − 0.27, p < 0.01), and maternal-infant bonding (r = 0.10, p < 0.01), and the overprotection attachment dimension was significantly associated with resilience (r = − 0.11, p < 0.01), PTSD (r = 0.33, p < 0.01), and maternal-infant bonding (r = 0.16, p < 0.01). Resilience and PTSD can mediate the relationship between attachment and maternal-infant bonding.

Conclusion
Parental attachment, resilience, and PTSD significantly affect maternal-infant bonding at 1 to 3 months postpartum.

Impact
This study demonstrated that new interventions aimed at addressing PTSD symptoms and improving resilience might increase parental attachment and maternal-infant bonding after birth. However, further research is required to evaluate the success of these interventions.
Examination of head versus body heading may help clarify the extent to which animal movement pathways are structured by environmental cues?
Authors: Gunner Richard M. , Wilson Rory P. , Holton Mark D. , Bennett Nigel C. , Alagaili Abdulaziz N. , Bertelsen Mads F. , Mohammed Osama B. , Wang Tobias , Manger Paul R. , Ismael Khairi , Scantlebury D. Michael 
Published: October 2023

AbstractUnderstanding the processes that determine how animals allocate time to space is a major challenge, although it is acknowledged that summed animal movement pathways over time must define space-time use. The critical question is then, what processes structure these pathways? Following the idea that turns within pathways might be based on environmentally determined decisions, we equipped Arabian oryx with head- and body-mounted tags to determine how they orientated their heads – which we posit is indicative of them assessing the environment – in relation to their movement paths, to investigate the role of environment scanning in path tortuosity. After simulating predators to verify that oryx look directly at objects of interest, we recorded that, during routine movement, > 60% of all turns in the animals’ paths, before being executed, were preceded by a change in head heading that was not immediately mirrored by the body heading: The path turn angle (as indicated by the body heading) correlated with a prior change in head heading (with head heading being mirrored by subsequent turns in the path) twenty-one times more than when path turns occurred due to the animals adopting a body heading that went in the opposite direction to the change in head heading. Although we could not determine what the objects of interest were, and therefore the proposed reasons for turning, we suggest that this reflects the use of cephalic senses to detect advantageous environmental features (e.g. food) or to detect detrimental features (e.g. predators). The results of our pilot study suggest how turns might emerge in animal pathways and we propose that examination of points of inflection in highly resolved animal paths could represent decisions in landscapes and their examination could enhance our understanding of how animal pathways are structured.
Chatbots and robots: a framework for the self-management of occupational stress
Authors: Yorita Akihiro , Egerton Simon , Chan Carina , Kubota Naoyuki 
Published: October 2023

AbstractWe have developed a stress management framework aimed at helping healthcare professionals manage occupational stress. A chatbot is used to gather pertinent information from a user through regular conversation which is processed via a fuzzy inference model to derive their level of occupational Comprehensibility, Manageability, Meaningful and overall occupational Sense of Coherence (SOC). This analysis feeds into a Peer Support model which selects the best intervention aimed at enhancing a user’s stress-coping abilities and reducing their levels of occupational stress. A trial has been conducted with working adults, and the results were examined using a questionnaire supported by Technology Acceptance Model, which showed that the chatbot could recognize the user's SOC, but left a challenge: few users wanted to continue using it in their daily lives.
Comparison of digital and traditional skin wound closure assessment methods in mice
Authors: Huang Coco X. , Siwan Elisha , Fox Sarah L. , Longfield Matilda , Twigg Stephen M. , Min Danqing 
Published: October 2023

Abstract
Background
Chronic skin wounds are a common complication of many diseases such as diabetes. Various traditional methods for assessing skin wound closure are used in animal studies, including wound tracing, calliper measurements and histological analysis. However, these methods have poorly defined wound closure or practical limitations. Digital image analysis of wounds is an increasingly popular, accessible alternative, but it is unclear whether digital assessment is consistent with traditional methods. This study aimed to optimise and compare digital wound closure assessment with traditional methods, using a diabetic mouse model. Diabetes was induced in male C57BL/6J mice by high-fat diet feeding combined with low dose (65 mg/kg of body weight) streptozotocin injections. Mice fed normal chow were included as controls. After 18 weeks, four circular full-thickness dorsal skin wounds of 4 mm diameter were created per mouse. The wounds were photographed and measured by callipers. Wound closure rate (WCR) was digitally assessed by two reporters using two methods: wound outline (WCR-O) and re-epithelialisation (WCR-E). Wounded skin tissues were collected at 10-days post-wounding and wound width was measured from haematoxylin and eosin-stained skin tissue.

Results
Between reporters, WCR-O was more consistent than WCR-E, and WCR-O correlated with calliper measurements. Histological analysis supported digital assessments, especially WCR-E, when wounds were histologically closed.

Conclusions
WCR-O could replace calliper measurements to measure skin wound closure, but WCR-E assessment requires further refinement. Small animal studies of skin wound healing can greatly benefit from standardised definitions of wound closure and more consistent digital assessment protocols.
Targeted Epidural Blood Patch Injection Through a Mini-Open Approach for Treatment of Spontaneous Intracranial Hypotension
Authors: Abboud Tammam , Behme Daniel , Schatlo Bawarjan , Rohde Veit , von der Brelie Christian 
Published: October 2023

BACKGROUND AND OBJECTIVES:
Spontaneous intracranial hypotension is recognized as a cause for refractory headache. Treatment can range from blind blood patch injection to microsurgical repair of the cerebrospinal fluid (CSF) leak. The objective of the study was to investigate the safety and efficacy of the targeted blood patch injection (TBPI) technique through a mini-open approach in treatment of refractory intracranial hypotension.

METHODS:
We retrospectively reviewed cases of 20 patients who were treated for spontaneous intracranial hypotension at our institute between 2011 and 2022. Head and spine MRI and whole-spine myelography were performed in an attempt to localize the CSF leak. All patients underwent implantation of two epidural drains above and beneath the index level through a minimally invasive interlaminar microsurgical approach under general anesthesia. Then, blood patch was injected under clinical surveillance. Treatment success and surgical complications were evaluated postoperatively and at follow-up.

RESULTS:
Patients presented with orthostatic headache, vertigo, sensory deficits, and hypacusis (95%, 15%, 15%, and 10%, respectively). Subdural effusions were present in 65% of the cases. A CSF leak was identified in all patients. The exact site of the CSF leak could be identified in 80% of cases. TBPI was performed with an average blood amount of 37.5 mL. A significant improvement of symptoms was reported in 90% of the cases. A total of 15% of the patients showed recurrent symptoms and underwent a second TBPI, resulting in symptom relief. No therapy-related complications were reported.

CONCLUSION:
TBPI is a safe and efficient treatment for spontaneous intracranial hypotension. It is performed in a minimally invasive procedure and can be repeated, if necessary, with a very low-risk profile.
Determinants of Military Spending in Africa: Do Institutions Matter?
Authors: Njamen Kengdo Arsène Aurelien , Nchofoung Tii N. , Kos A Mougnol Alice 
Published: October 2023

Abstract
This paper focuses on the determinants of military spending in Africa by considering the role played by institutions. With data obtained between the years 1996–2019, the Driscoll and Kraay fixed effects, the Generalised Method of Moments (GMM), and the Bayesian Model Averaging (BMA) estimators are used. The findings suggest that government size, trade freedom, economic risk, and political risk decrease military spending, whereas government stability and military involvement in politics are found to raise it. Using alternative institutional variables, we find that corruption, government effectiveness, political stability, regulatory quality, the rule of law, and voice and accountability significantly diminish military spending in Africa. In addition, concerning the economic determinants, the results reveal that trade openness and total natural resource rents reduce military spending, while GDP per capita, inflation, and foreign debt stocks increase it. Looking at strategic determinants, arms imports, urban population, and ethnic tensions positively affect African military expenditures. Robustness checks show that these results change once regional specificities are considered. The study concludes that institutional factors could be an engine for evolution in Africa’s military spending.
The inhumanity of people living in Slovak Roma settlements: on the creation of the focal images
Authors: Kobes Tomáš 
Published: October 2023

Abstract
This text deals with convergence and divergence in relation to the formation of images of inhumanity in Slovak Roma settlements. Slovak media, social networks, and television reports often contain negative images emphasizing the Roma’s backwardness, irrationality, superstition, and cruelty, and aiming to highlight their inhumanity. This approach has become prevalent even among official state authorities such as the police of the Slovak Republic, shaping the perception of the Roma as monsters. It represents a mobilization strategy that connects and disconnects various disciplinary apparatuses, forming concrete images of monsters. By examining moments of convergence and divergence, which mainly focus on the killing and consumption of canines, the text clarifies the social and material ordering that contributes to the particular arrangement of significance used by the Slovak media and other officials.
Language Attitudes of Polish Youth in Lithuania
Authors: Geben Kinga 
Published: October 2023

The aim of this study is to determine the attitudes of Polish youth in Lithuania towards the Lithuanian, Russian, English, and Polish languages. The material has been drawn from qualitative research conducted through questionnaires. In order to summarize the results of the research, 147 questionnaires completed by respondents aged 16–34, who declared Polish nationality, were selected. The survey was done between February 20 and March 3, 2023, via Google Forms. Results of the 2023 attitude survey were compared with those of the 2010 sociolinguistic survey. 98.6% (n = 145) of the young respondents consider Polish to be their mother tongue or one of their mother tongues, which is 18.4% higher than the result obtained in the 2010 survey. Preferences for the most beautiful, the necessary, the most common, and the most prestigious language were compared with the preferences that were described in my article (Geben 2013). Results of the statistical analysis show that Lithuanian is the most frequently mentioned language among the most necessary languages, but English is still the language the most in need for young respondents (63.9%, n = 94). Polish retains its position as the most beautiful language for those whose mother tongue is Polish. Polish has become the most common language for young respondents (67.3%, n = 99), with Russian still in a second place in this category (47.6%, n = 70).
The aim of this study is to determine the attitudes of Polish youth in Lithuania towards the Lithuanian, Russian, English, and Polish languages. The material has been drawn from qualitative research conducted through questionnaires. In order to summarize the results of the research, 147 questionnaires completed by respondents aged 16–34, who declared Polish nationality, were selected. The survey was done between February 20 and March 3, 2023, via Google Forms. Results of the 2023 attitude survey were compared with those of the 2010 sociolinguistic survey. 98.6% (n = 145) of the young respondents consider Polish to be their mother tongue or one of their mother tongues, which is 18.4% higher than the result obtained in the 2010 survey. Preferences for the most beautiful, the necessary, the most common, and the most prestigious language were compared with the preferences that were described in my article (Geben 2013). Results of the statistical analysis show that Lithuanian is the most frequently mentioned language among the most necessary languages, but English is still the language the most in need for young respondents (63.9%, n = 94). Polish retains its position as the most beautiful language for those whose mother tongue is Polish. Polish has become the most common language for young respondents (67.3%, n = 99), with Russian still in a second place in this category (47.6%, n = 70).
trabalho colaborativo como princípio da educação inclusiva
Authors: Haas Clarissa , Aurélio Bezerra Querubina 
Published: October 2023

O presente estudo aborda os processos escolares inclusivos no Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul (IFRS), campus Caxias do Sul, mediante o contexto de pandemia ocasionado pela covid-19, com foco no trabalho colaborativo como princípio da educação inclusiva e no direito à acessibilidade curricular dos estudantes com necessidades educacionais específicas (NEE). A abordagem metodológica é qualitativa e se estrutura por meio de um estudo documental envolvendo documentos institucionais do IFRS, com ênfase nas orientações elaboradas para o ensino remoto e nas atas do Grupo de Trabalho Ensino, vinculado ao NAPNE, referentes ao período de maio a agosto de 2021. São estabelecidos como eixos de análise a gestão da educação inclusiva e a identificação e redução de barreiras para a promoção de acessibilidade curricular. Analisa-se que o contexto de urgências intensificadas pelo ensino remoto, embora tenha agravado algumas barreiras no acesso ao conhecimento, mobilizou o trabalho colaborativo entre os agentes e o amadurecimento das práticas de gestão dos processos inclusivos fomentados pelo NAPNE e das múltiplas ações que visam a promoção da acessibilidade curricular aos estudantes com NEE. Conclui-se que o NAPNE é um agente articulador da Política Nacional de Educação Especial na Perspectiva da Educação Inclusiva nos institutos federais, requerendo esforços institucionais que viabilizem o fortalecimento do núcleo e a continuidade das ações desenvolvidas.
Projeto político pedagógico de uma escola quilombola na Amazônia, Pará
Authors: Miranda da Silva Renato , Nascimento de Melo Clarice 
Published: October 2023

Objetivamos identificar as aproximações e os distanciamentos existentes entre o prescrito no PPP da Escola Municipal de Ensino Infantil e Fundamental Nossa Senhora do Perpétuo Socorro-II (Quilombola) e as diretrizes curriculares nacionais que subsidiam a educação quilombola. Metodologicamente este artigo valeu-se da análise documental, com base na análise de conteúdo, definindo como unidade de contexto os indicadores de aproximações entre os documentos objeto de estudo, em seguida realizamos a descrição das fontes, seguindo para as inferências e interpretação. Usamos como fonte de pesquisa o Projeto Político Pedagógico da escola e os documentos curriculares voltados para a Educação Quilombola. Concluímos com a análise de conteúdo que o PPP cumpre de forma satisfatória seu papel e se mostra bastante inteirado das diretrizes nacionais, apesar das dificuldades de uma escola quilombola na Amazônia.
GOODS AND CASH FLOWS AND MACROECONOMIC EQUILIBRIUM UNDER THE CONDITIONS OF THE MODEL OF A HIGHLY EFFICIENT NATIONAL ECONOMY
Authors: MYAMLIN V. V. 
Published: October 2023

The purpose of the research is to increase the effectiveness of the functioning of the "mechanism" of the national economy and to inform the scientific and economic public about possible alternative "mechanisms" of its functioning. The methodology consists in the use of a systemic approach, the method of aggregation, as well as the use of analogies borrowed from nature and from closed technical processes that have already been built and are successfully functioning on the basis of universal conservation laws. In the simulation modeling of this economic model, the methodology of the theory of piecewise linear aggregates was used. The results. It is shown how commodity and money flows will be directed in the conditions of functioning of the model of a highly efficient national economy. It is proven that the gross domestic product must correspond to the purchasing power of the population. At the same time, all the contradictions inherent in the modern economy and, above all, crisis phenomena are absent. The scientific novelty lies in the fact that for the first time scientifically based principles and rules of functioning, completely different from the existing economic model, have been adopted. For example, there is no such economic category as "profit", the price of goods is determined according to other principles, a new and very simple taxation system is proposed, the amount of money in the system is constantly and does not increase. The conceptual and terminological apparatus, which allows to form the appropriate theoretical and methodological foundations of the system of highly efficient functioning of the national economy, has gained further development. Practical significance of the research. The transition to the proposed macroeconomic model in Ukraine will provide an annual economic effect of at least one trillion hryvnias, and budget revenues will increase by approximately four hundred million hryvnias.