bluuebunny/crossref_metadata_2025_split huggingface dataset:
SENSE-Cog Residential Care: Hearing and vision support for residents with dementia in long-term care in Ireland: Protocol for a pilot cluster randomised controlled trial
Authors: Connelly JP , Boland Erin , Buckley Brenda , Curley Niall , Refaie Amr El , Galvin Miriam , Gibb Matthew , Graham Liz , Lennon Brendan , Valdes Alejandro Lopez , Mullally Anne-Michelle , Muller Nicole , Nolan-Palmer Janice , O'Nolan Gerald , O'Reilly Ciara , Rezk Valeria Raaft , Rochford-Brennan Helen , Tobin Katy , Tormey Helen , Trepel Dominic , Leroi Iracema 
Published: October 2023

Abstract

Background
Hearing and vision loss is highly prevalent in residents with dementia (RwD) living in long-term care (LTC) facilities. Sensory loss often has a negative impact on quality of life and other dementia-related outcomes. Optimising sensory function may improve dementia-related outcomes in LTC facilities. The SENSE-Cog Residential Care pilot trial will evaluate whether a multi-faceted hearing and vision intervention for RwD and concurrent sensory loss is suitable for definitive testing in a large-scale cluster randomised control trial (RCT) in Ireland, and how this can best be achieved.
Methods
This is a six-month feasibility-pilot observer-blind, multicentre, cluster RCT. Between eight and 15 LTC facilities (with an average of 5 RwD recruited per home) will be randomly assigned to receive either "care as usual" (CAU) or a multi-component sensory intervention comprising: (1) personalised resident hearing and vision support; (2) staff training in sensory health; (3) fostering a 'sensory 'friendly' environment; and (4) optimising care pathways to hearing/vision care providers. The intervention's feasibility, acceptability, and tolerability for residents and staff will be examined. In addition, a battery of exploratory outcome measures will be evaluated for suitability for the definitive trial and to inform the choice of primary and secondary outcome measures.
Discussion
If the SENSE-Cog Residential Care pilot trial demonstrates that the sensory support intervention for residential care is feasible and tolerated in LTC facilities in Ireland, we will conduct a larger definitive trial to evaluate its effectiveness in improving dementia-related outcomes. Training materials, resources, and information will be made available to health and social care providers to enable the implementation of sensory support for RwD in routine LTC, potentially improving the quality of such care in Ireland.
Trial registration
ISRCTN, ISRCTN14462472. Registered 24 February 2022, https://doi.org/10.1186/ISRCTN14462472
Hydraulic flow unit and rock types of the Asmari Formation in the Mansouri oilfield, an application of the Flow zone index and Fuzzy C-means clustering methods
Authors: Eftekhari Seyedeh Hajar , Memariani Mahmoud , Maleki Zahra , Aleali Mohsen , Kianoush Pooria 
Published: October 2023

Abstract
Rock types are the reservoir's most essential properties for special facies modeling in a defined range of porosity and permeability. This study used the fuzzy c-means clustering technique to identify rock types in 280 core samples from one of the wells drilled in the Asmari reservoir in the Mansouri field, SW Iran. Four hydraulic flow units were determined for studied data after classifying the flow zone index with histogram analysis, normal probability analysis, and the sum of square error methods. Then two methods of flow zone index and fuzzy c-means clustering were used to determine the rock types in given wells according to the results obtained from the implementation of these two methods in-depth, and continuity index acts, the fuzzy c-means methods with continuity number 3.12 compared to flow zone index with continuity number 2.77 shows more continuity in depth. The relationship between permeability and porosity improved utilizing hydraulic flow unit techniques considerably. This improvement is achieved using the flow zone index method study. So that in the general case, all samples increased from 0.55 to 0.81 in the first hydraulic flow unit and finally 0.94 in the fourth hydraulic flow unit. The samples were characterized by similar flow properties in a hydraulic flow unit. In comparison, the obtained correlation coefficients in the fuzzy c-mean method are less than the general case in all hydraulic flow units. This study aims to determine the flowing fluid in the porous medium of the Asmari reservoir employing the c-mean fuzzy logic. Also, by determining the facies of the rock units, especially the siliceous-clastic facies and log data in the Asmari Formation, the third and fourth flow units have the best flow units with high reservoir quality and permeability. Results can compared to the flow unit determination in other nearby wellbores without cores.
Developing a competency assessment framework for pharmacists in primary health care settings in India
Authors: Kumar Sanjeev , Bhoi Purnima , Gharat Manjiri Sandeep , Mohanta Guru Prasad 
Published: October 2023

Abstract

Background
Pharmacists play a significant role in primary health Care. The competence assessment of pharmacists is a critical driver for enhancing primary healthcare performance. While several countries have developed competency frameworks for pharmacists in primary care, such frameworks are lacking in the Indian context.
Methods
This study aimed to develop a competency assessment framework for in-service pharmacists in Indian public primary healthcare settings. A five-stage consultative process was followed. In the first stage, a systematic literature review was conducted to identify pharmacist competencies in the primary healthcare setting. Expert consultations were then organized to build consensus on competencies and behaviours. Competency assessment tools were developed based on the literature and experts' agreements. Another round of expert consultation was conducted to achieve consensus on the competency assessment tools. Finally, the tools were tested in a public primary healthcare facility.
Results
The systematic literature review identified 20 competencies and 175 associated behaviors distributed across four domains: Pharmaceutical Health, Pharmaceutical Care, Organization and Management, and Professional/Personal. Expert consultations resulted in the consensus on 11 roles of pharmacists in primary healthcare settings. Competencies and associated behaviors were discussed and agreed upon for each role.
Conclusions
This study successfully developed a competency assessment framework for in-service pharmacists in Indian public primary healthcare settings. The framework encompasses 20 competencies and associated behaviors, covering various domains and roles of pharmacists. It provides a comprehensive tool for assessing pharmacist competencies and identifying competency gaps. The framework can be used to capacitate pharmacists, improve the performance of pharmacists in primary healthcare settings, and enhance the delivery of healthcare services in India. It fills a critical gap in the existing literature and can serve as a valuable resource for policymakers, educators, and healthcare professionals involved in pharmacy practice in primary care settings.
Challenges in the Diagnosis of Infantile Enterocolitis and RareAuto-inflammatory Syndromes: A Case Report and Literature Review
Authors: Khalesi Maryam , Jafari Seyed Ali , Kianifar Hamidreza , Malek Abdolreza , Vahedi Mahdieh 
Published: October 2023

Abstract
Introduction: Auto-inflammatory syndromes are characterized by systemic inflammation and a broad spectrum of clinical manifestations. The Gastrointestinal mucosa has a critical role in the immune system. Autosomal dominant mutations in the NLRC4 gene have been associated with systemic auto-inflammation and early-onset infantile enterocolitis. The main aim of our study is to highlight the importance of monogenic auto-inflammatory syndromes in early-onset enterocolitis. We provided a literature review of NLRC4-inflammasome-mediated auto-inflammatory disease.
Case presentation: This case report described a 3-year-old female child with very early-onset enterocolitis and a missense mutation in exon 4 of the NLRC4 gene. Colonic mucosal biopsy showed colitis. Whole exome sequencing revealed a missense mutation in exon 4 of the NLRC4 gene.
Conclusions: Most auto-inflammatory disorders are rare and Patients have always experienced a diagnostic and treatment delay. Intestinal inflammation is one of the clinical presentations of auto-inflammatory syndromes. Auto-inflammatory diseases have a broad spectrum of clinical characteristics, and the gastrointestinal tract is frequently involved. Monogenic auto-inflammatory diseases such as NLRC4 gene mutations should be considered a rare cause of chronic intestinal inflammation and early-onset enterocolitis.
Consumer attitudes towards purchasing refurbished smartphones in developed and developing countries: social media analytics
Authors: mounesan milad 
Published: October 2023

Abstract
In recent years, the amount of electronic waste has dramatically increased due to the short end-of-life (EOL) products, rapid expansion, and variety of electronic products; therefore, refurbishing these products is one of the practical and sustainable solutions to this issue. Customer reviews play a crucial role in determining purchasing behaviors and attitudes. To this end, a customer satisfaction model of online refurbished smartphone reviews was presented to investigate customer satisfaction dimensions (CSDs) toward refurbished smartphones by opinion mining and analyzing the data of customer reviews on Twitter from consumers of refurbished smartphones in developed and developing countries. For this purpose, we separated the refurbished reviews into two distinct categories: (i) direct evaluations of refurbished features by utilizing machine learning to identify features and determine how individuals feel about them, and (ii) indirect evaluations based on product remanufacturers' claims that refurbished and new products are comparable. The findings indicate that buyers of refurbished smartphones are most concerned with the product's features, such as its functionality, price, and guarantee conditions. In addition, we observed that while consumers in developed countries pay special attention to the environment, consumers in developing countries are more concerned with guarantees and pricing. These findings suggest economic factors as the main reason for smartphone purchases in developing countries for refurbished products. In contrast, due to greater economic prosperity in developed countries, environmental considerations were determined as the main reason for purchasing refurbished smartphones.
Predictive Machine Learning Model for Early Detection of Type 2 Diabetes Using Patients’ Clinical Symptoms, Demographic Features, and Knowledge of Diabetes
Authors: Ojurongbe Taiwo Adetola , Afolabi Habeeb Abiodun , Oyekale Adesola , Bashiru Kehinde Adekunle , Ayelagbe Olubunmi , Ojurongbe Olusola , Abbasi Saddam Akber , Adegoke Nurudeen A. 
Published: October 2023

Abstract
Background: Type 2 diabetes is commonly diagnosed at a later stage due to low attendance to health examinations, especially among certain demographic groups with financial constraints, differences in self-care routines, and medical habits. Given these circumstances, the need to develop reliable predictive tools for type 2 diabetes is becoming increasingly pressing.
Methods: To address this, we routinely collected health checkup data from patients with diabetes and used their clinical symptoms, demographics, and diabetes knowledge to predict the disease onset. Data from 444 Nigerian patients were used to develop a predictive model, with 80% of the dataset selected for training and the remaining 20% for testing.
Results: Using multivariable penalised logistic regression, we predicted type 2 diabetes with an AUC of 99% (95% confidence interval [CI] = 97% - 100%) for the training set and 94% (95% CI = 89% - 99%) for the test set, incorporating waist-hip ratio (WHR), triglycerides (TG), catalase, and atherogenic indices of plasma (AIP) as informative features. A significant increase in the adjusted odds ratios (AOR) of type 2 diabetes was observed with WHR (AOR = 70.35; 95% CI = 10.04 - 493.1, p-value < 0.0001) and AIP (AOR = 4.55; 95% CI = 1.48 - 13.95, p-value = 0.0081). Meanwhile, TG had an increased adjusted odds ratio of 1.04 for type 2 diabetes (95% CI = 0.4 - 2.71), although this association was not statistically significant (p-value = 0.9377). Conversely, catalase exhibited a decreased adjusted odds ratio for type 2 diabetes (AOR = 0.33; 95% CI = 0.22 - 0.49, p-value < 0.0001).
Conclusion: Our study revealed associations between clinical symptoms and type 2 diabetes, emphasising the crucial role of early diagnosis. A web application is provided to aid the early identification of at-risk individuals, reduce health complications, and address inconsistent checkup gaps.
Monogenic Systemic Lupus Erythematosus onset in a 13-year-old boy with Noonan like-syndrome: a case report and literature review
Authors: Moran-Alvarez Patricia , Gianviti Alessandra , Diomedi-Camassei Francesca , Ginevrino Monia , de Benedetti Fabrizio , Bracaglia Claudia 
Published: October 2023

Abstract
Background: Childhood systemic lupus erythematosus (cSLE) has been considered as a polygenic autoimmune disease; however, a monogenic lupus-like phenotype is emerging with the recent recognition of several related novel high-penetrance genetic variants. RASopathies, a group of disorders caused by mutations in the RAS/MAPK pathway, have been recently described as a cause of monogenic lupus.
Case presentation: we present a 13-year-old boy with Noonan-like syndrome with loose anagen hair who developed a monogenic lupus. The renal biopsy confirmed a class III lupus nephritis and identified the presence of zebra bodies.
Conclusions: RASopathies represent a cause of monogenic lupus. We report a new case of monogenic lupus in a child with Noonan-like syndrome with loose anagen hair. Lupus nephritis which has never been described in this context, may be part of the presentation. The presence of zebra bodies in SLE or RASopathies in unclear, but no other known conditions (Fabry disease or drugs) were identified as the cause of zebra bodies in our patient.
NCAPH Drives Breast Cancer Progression and Identifies a Gene Signature that Predicts Luminal A Tumor Recurrence
Authors: Mendiburu-Eliçabe Marina , García-Sancha Natalia , Corchado-Cobos Roberto , Martínez-López Angélica , Chang Hang , Mao Jian Hua , Blanco-Gómez Adrián , García-Casas Ana , Castellanos-Martín Andrés , Salvador Nélida , Jiménez-Navas Alejandro , Pérez-Baena Manuel Jesús , Sánchez-Martín Manuel Adolfo , Abad-Hernández María Del Mar , Carmen Sofía Del , Claros-Ampuero Juncal , Cruz-Hernández Juan Jesús , Rodríguez-Sánchez César Augusto , García-Cenador María Begoña , García-Criado Francisco Javier , Vicente Rodrigo Santamaría , Castillo-Lluva Sonia , Pérez-Losada Jesús 
Published: October 2023

Abstract
Despite their generally favorable prognosis, luminal A tumors paradoxically pose the highest ten-year recurrence risk among breast cancers. From those that relapse, a quarter of them do it within five years after diagnosis. Identifying such patients is crucial, as long-term relapsers could benefit from extended hormone therapy, whereas early relapsers may require aggressive treatment. In this study, we demonstrate that NCAPH plays a role in the pathogenesis of luminal A breast cancer, contributing to its adverse progression in vitro and in vivo. Furthermore, we reveal that a signature of intratumoral gene expression, associated with elevated levels of NCAPH, serves as a potential marker to identify patients facing unfavorable progression of luminal A breast cancer. Indeed, transgenic mice overexpressing NCAPH generated breast tumors with long latency, and in MMTV-NCAPH/ErbB2+ double-transgenic mice, the luminal tumors formed were more aggressive. In addition, high intratumoral levels of Ncaphwere associated with worse breast cancer evolution and poor response to chemotherapy in a cohort of genetically heterogeneous transgenic mice generated by backcrossing. In this cohort of mice, we identified a series of transcripts associated with elevated intratumoral levels of NCAPH, which were linked to adverse progression of breast cancer in both mice and humans. Utilizing the Least Absolute Shrinkage and Selection Operator (LASSO) multivariate regression analysis on this series of transcripts, we derived a ten-gene risk score. This score is defined by a gene signature (termed Gene Signature for Luminal A 10 or GSLA10) that correlates with unfavorable progression of luminal A breast cancer. The GSLA10 signature surpassed the Oncotype DX signature in discerning tumors with unfavorable outcomes (previously categorized as Luminal A by PAM50) across three independent human cohorts. This GSLA10 signature aids in identifying patients with Luminal A tumors displaying adverse prognosis, who could potentially benefit from personalized treatment strategies.
Otoscopy-Assisted Intranasal Cyst Marsupialization for Congenital Dacryocystocele
Authors: MD  , MD  , MD  , MD  , MD  , MD  
Published: October 2023

Abstract

Purpose
We report a novel, simple intranasal cyst marsupialization (ICM) technique for congenital dacryocystocele (CDC).
Design:
Prospective observational study
Methods
Twenty consecutive infants with 25 CDCs treated at our facility from 2011 to July 2023 were enrolled. Five infants with five CDCs required surgical interventions due to resistance to conservative treatment. Among these five infants, we evaluated the surgical method and the outcomes in three infants with three CDCs who underwent otoscopy-assisted ICM.
Results
Of the total 25 CDCs, 20 (80%) spontaneously resolved with conservative treatment. Surgical intervention was conducted on five consecutive infants with five CDCs. The mean age at surgery was 100.8 (standard deviation [SD] = 77.6) postnatal days. The surgical procedures involved one of the following methods: (1) Probing by an ophthalmologist (2 CDCs); (2) Otoscopy-guided ICM performed by an otolaryngologist in the manner of otoscopic myringotomy (3 CDCs). All infants were treated successfully by a single surgical procedure under topical anesthesia in an office setting.
Conclusion
CDC was successfully treated by ICM in the manner of an otoscopic myringotomy. Treatment of CDC using an otoscope and myringotome is a minimally invasive surgical procedure that can be performed in an office setting without the need for general anesthesia or advanced medical equipment such as a nasal endoscope. Moreover, the risk of false passage formation and/or recurrence after probing can be avoided. Therefore, we propose this procedure as one of the practical ICM techniques for CDC.
Evaluation of Atmospheric Environmental Efficiency and Spatiotemporal Differences in the Yangtze River Delta Region of China
Authors: Yang Chuanming , Shen Jie , Jiang Zhonghua , Chen Junyu , Xie Yi 
Published: October 2023

Abstract
The scientific measurement of regional atmospheric environmental efficiency is an important prerequisite for achieving energy conservation, haze reduction, and regional green and high-quality development. Taking the urban agglomeration of the Yangtze River Delta region from 2012 to 2021 as the research object, the three-stage DEA model and Malmquist index are used to measure atmospheric environmental efficiency from static and dynamic perspectives and analyze spatial and temporal differences. The study found that there is still room for improvement in the atmospheric environmental efficiency of the Yangtze River Delta urban agglomeration, and pure technical efficiency is the main factor leading to overall low efficiency. Different environmental variables have different impacts on atmospheric environmental efficiency, with industrial structure having the most significant effect. Total factor productivity of the atmosphere showed a gradual increase over the study period, with technological progress playing the most important role in contributing. Observing the three types of efficiency values for each city using the mean efficiency as a critical point, except for Shanghai, each province has two or more low efficiency problems. Based on these findings, policy recommendations are proposed to further improve the level of atmospheric environmental governance in the Yangtze River Delta region.
Biological efficacy of simulated radiolabeled Lipiodol® ultra-fluid and microspheres for various beta emitters: study based on VX2 tumors
Authors: Dieudonné Arnaud , Becker Stéphanie , Soares Miguel , Hollenbeck Claire , De Goltstein Marie-Christine , Vera Pierre , Santus Robin 
Published: October 2023

Abstract
Background
Radioembolization is one therapeutic option for the treatment of locally early-stage hepatocellular carcinoma. The aim of this study was to evaluate the distribution of Lipiodol® ultra-fluid and microspheres and to simulate their effectiveness with different beta emitters (90Y, 188Re, 32P, 166Ho, 131I, and 177Lu) on VX2 tumors implanted in the liver of 30 New Zealand rabbits.
Results
Twenty-three out of 30 rabbits had exploitable data: 14 in the group that received Lipiodol® ultra-fluid (group L), 6 in the group that received microspheres (group M), and 3 in the control group (group C). The histologic analysis showed that the Lipiodol® ultra-fluid distributes homogeneously in the tumor up to 12 days after injection. The X-ray mCT images showed that Lipiodol® ultra-fluid has a more distal penetration in the tumor than microspheres. The entropy (disorder of the system) in the L group was significantly higher than in the M group (4.06 vs 2.67, p=0.01). Equivalent uniform biological effective doses (EUBED) for a tumor-absorbed dose of 100 Gy were greater in the L group but without statistical significance except for 177Lu (p=0.03). The radionuclides ranking by EUBED (from high to low) was 90Y, 188Re, 32P, 166Ho, 131I, and 177Lu.
Conclusions
This study showed a higher ability of Lipiodol® ultra-fluid to penetrate the tumor that translated into a higher EUBED. This study confirms 90Y as a good candidate for radioembolization, although 32P, 166Ho, and 188Re can achieve similar results.
Competition of cortical clusters during on-demand visual learning in immersive virtual reality
Authors: Rozsa Balazs , Judák Linda , Dobos Gergely , Ócsai Katalin , Takács István , Báthory Eszter , Chiovini Balázs , Szadai Zoltán , Maák Pál , Szepesi Áron , Roska Botond , Szalay Gergely 
Published: October 2023

Abstract

Neural circuits support rapid visual learning. However, due to technical roadblocks, it is not known how visual circuits represent multiple features or how behaviorally relevant representations are selected for long-term memory. Here we developed Moculus, a head-mounted virtual reality platform for mice that covers the entire visual field, and allows binocular depth perception and full immersion. This controllable environment, combined with fast acousto-optical imaging, affords rapid visual learning and the uncovering of novel circuit substrates: both the control and reinforcement-associated visual cue coding neuronal assemblies are extended transiently to a near-saturating level. They formed partially orthogonal and overlapping clusters centered around hub cells with higher and earlier ramp-like responses, as well as locally increased connectivity. This temporally maximizes computational capability and allows competition between assemblies that encode behaviorally relevant information by stochastic fluctuation from trial-to-trial. The coding competition is driven by reinforcement feedback at the level of individual neurons.