bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abordaje Integral de la Enfermedad Inflamatoria Intestinal: Cirugía y Medicina Interna en Sintonía
Authors: Quezada Narváez Carlos Eduardo , Gonzalez Erazo Ana María , Rivadeneira Torres Karol Elizz , Tigselema Maquizaca Andrea Estefania , García Párraga Ronnie Eudes , Perez Alvarez Juan Miguel , Naranjo Albán Samijazath Alexander 
Published: December 2023

Introducción: La Enfermedad Inflamatoria Intestinal (EII) plantea desafíos complejos que requieren un abordaje integral. Desde avances en el diagnóstico hasta terapias personalizadas y enfoques multidisciplinarios, este artículo explora las últimas investigaciones y aplicaciones prácticas en la gestión de la EII. La integración de la medicina de precisión, el tratamiento quirúrgico avanzado y las estrategias de atención centradas en el paciente reflejan la evolución constante en la comprensión y el manejo de esta enfermedad crónica.
Desarrollo: El desarrollo aborda exhaustivamente la Enfermedad Inflamatoria Intestinal (EII), explorando estrategias terapéuticas en medicina interna y cirugía. Desde aminosalicilatos hasta terapias biológicas, se destaca la diversidad de enfoques médicos. Además, se analizan las indicaciones quirúrgicas comunes, técnicas avanzadas y evaluación preoperatoria.
Aplicaciones prácticas: Las futuras líneas de investigación buscan avanzar en la medicina personalizada y terapias emergentes para la Enfermedad Inflamatoria Intestinal (EII). La nanotecnología, modulación del microbioma y la telemedicina son áreas de interés, prometiendo mejorar la precisión diagnóstica y las opciones terapéuticas.
Conclusiones: En conclusión, el abordaje integral de la Enfermedad Inflamatoria Intestinal (EII) requiere estrategias multidisciplinarias, desde diagnóstico preciso hasta tratamientos personalizados. Las investigaciones emergentes señalan hacia terapias prometedoras, transformando la gestión y ofreciendo esperanza a los pacientes.
Beleid en Maatschappij 50 jaar
Authors: Verloo Nanke , Metze Tamara , Hochstenbach Cody , Hoekstra Myrte , Brons Claartje , Miltenburg Emily , Bannink Duco , van Ostaijen Mark 
Published: December 2023

Van de redactie
This editorial offers an introduction to the current issue.
Refractive Surgery Overview
Authors: Stein Raymond , Stein Rebecca 
Published: December 2023

Advancements in technology and techniques are continuously shaping the field of refractive surgery for the correction of myopia, hyperopia, astigmatism, and presbyopia. As a result, more patients are seeking alternatives to spectacles or contact lenses. Clinicians must stay up-to-date with the latest options available for vision correction. This article aims to provide a comprehensive overview of the exciting progress being made in this area of clinical advancements and research.
La revolución de la Inteligencia Artificial en tiempos de negacionismo tecnológico
Authors: Prendes-Espinosa Mª Paz 
Published: December 2023

Artificial Intelligence has been developing technically for decades, but it is in 2022 when the irruption of ChatGPT shakes the foundations of educational systems and all teachers, academics and people involved in one way or another in education. The need arises to know what it is, what it is for and what implications it can have on our systems, models and strategies in education. In this article we explain what Artificial Intelligence is and address some reflections on its educational impact. We also suggest in this article some Artificial Intelligence tools that may be useful to teachers, researchers, students and in general, to anyone interested in knowing a little better what this innovative technology -which we have called the "fourth educational revolution"- can be used for. Finally, we make some recommendations on their use in education.
La Inteligencia Artificial lleva desarrollándose técnicamente durante décadas, pero es en 2022 cuando la irrupción de ChatGPT hace temblar los cimientos de los sistemas educativos y de todos los docentes, académicos y personas involucradas de un modo u otro en la formación. Surge la necesidad de saber qué es, para qué sirve y qué implicaciones puede tener en nuestros sistemas, modelos y estrategias en educación. En este artículo explicamos qué es la Inteligencia Artificial y abordamos algunas reflexiones sobre su impacto educativo. Además sugerimos algunas herramientas de Inteligencia Artificial que pueden ser útiles a los docentes, a los investigadores, a los estudiantes y en general, a cualquier persona interesada en conocer un poco mejor para qué se puede usar esta tecnología innovadora que hemos denominado como la "cuarta revolución educativa". Por último, hacemos algunas recomendaciones sobre su uso en educación.
The Aurora kinase inhibitor AT9283 inhibits Burkitt lymphoma growth by regulating Warburg effect
Authors: Jiang Kaiming , Bai Lihong , Wang Canfei , Xiao Xiang , Cheng Zhao , Peng Hongling , Liu Sufang 
Published: December 2023

Objective
To investigate the effect of the kinase inhibitor AT9283 on Burkitt lymphoma (BL) cells and elucidate the underlying mechanisms.

Methods
The effect of AT9283 on the proliferation of BL cell lines was tested using the MTT assay. Apoptosis and cell cycle were measured by flow cytometry. The proteins associated with the cell cycle, apoptosis, and the Warburg effect were detected using Western blotting. Alterations in glycolytic metabolism in terms of glucose intake and lactate concentrations were determined by glucose and lactate assays.

Results
The current study utilized the GEPIA, the Human Protein Atlas (HAP) database and immunohistochemistry to conduct analyses, which revealed a high expression of Aurora kinases and Warburg effect-related proteins in malignant B-cell lymphoma tissues. AT9283 significantly inhibited the cell proliferation of BL cells and induced G2/M arrest. Additionally, AT9283 induced apoptosis in BL cells and reversed the Warburg effect by increasing glucose uptake and reducing lactate production. Moreover, the protein expression of hexokinase 2, pyruvate kinase M2, and lactate dehydrogenase A was significantly suppressed by AT9283, possibly through the inhibition of c-Myc and HIF-1α protein expression.

Conclusion
The reversal of the Warburg effect in BL cells and the subsequent inhibition of cell proliferation and induction of apoptosis were observed by targeting Aurora A and Aurora B with AT9283. This finding may present new therapeutic options and targets for BL.
Feasibility of using chest computed tomography (CT) imaging at the first lumbar vertebra (L1) level to assess skeletal muscle mass: a retrospective study
Authors: Liu Shaohua , Han Xia , Li Jianjun , Xie Xia , Yang Yunkai , Jiang Wangyan , Liu Li , Liu Zhelong 
Published: December 2023

Background
Skeletal muscle mass is an essential parameter for diagnosing sarcopenia. The gold standard for assessing skeletal muscle mass is using computed tomography (CT) to measure skeletal muscle area at the third lumbar vertebra (L3) level. This study aims to investigate whether skeletal muscle mass could be evaluated at the first lumbar vertebra (L1) level using images obtained from routine chest CT scans.

Methods
Skeletal muscle index (SMI, cm2/m2) and skeletal muscle density (SMD, HU) are commonly used to measure relative muscle mass and the degree of fat infiltration. This study used CT images at the L1 level to measure the skeletal muscle area (SMA, cm2) in 815 subjects from the health examination center. Linear regression analysis was used to explore the association between L1 and L3 measurements. The receiver operating characteristic (ROC) analysis was used to assess the predictive performance of L1 SMI for sarcopenia. The sex-specific cut-off values for low skeletal muscle mass in patients under the age of 60 were determined using the following formula: “mean − 1.28 × standard deviation.” A multivariate linear regression model was established.

Results
A significantly higher SMI at the L1 level was found in males than in females (43.88 ± 6.33 cm2/m2 vs 33.68 ± 5.03 cm2/m2; P < 0.001). There were strong correlations between measures at the L1 and L3 levels in both the total subject and sex-specific analyses. A negative association was found between age and L3 SMI in males (r = −0.231, P = 0.038). Both body mass index (BMI) and body surface area (BSA) were positively associated with L1 SMI in both males and females. A multivariate analysis was used to establish a prediction rule to predict SMI at the L3 level. The assessment of consistency and interchangeability between predicted and actual SMI at the L3 level yielded moderately good results. Considering the significant differences observed between male and female participants, the sex-specific cut-off values of the L1 SMI for defining low skeletal muscle mass were 36.52 cm2/m2 in males and 27.29 cm2/m2 in females.

Conclusions
Based on a population from central China, the correlated indicators obtained at the L1 level from routine chest CT scans may serve as effective surrogate markers for those at the L3 level in assessing overall skeletal muscle mass.
In Situ Crystallization of Copper(I)‐Based Hybrid Halides Assisted by Carboxymethylcellulose Sodium for a Large‐Area Scintillation Imaging Screen
Authors: Tang Baoling , Jin Jiance , Han Kai , Li Tianrui , Zhang Haoran , Zhang Xuejie , Molokeev Maxim , Wang Yuzhen , Xia Zhiguo , Lei Bingfu 
Published: February 2025

AbstractExploring new types of scintillators, especially fabricating large‐area scintillating screens, is essential in applications of life science, industry, and material science. However, the thickness and light scattering in composite scintillator film present a major challenge for balancing the spatial resolution and radioluminescence intensity. Herein, an in situ crystallization route is developed to innovate the preparation of the large‐area scintillating screens based on the hybrid copper(I)‐based C6H8N2OCuX (X = I and Br), in which carboxymethylcellulose sodium (CMC‐Na) contribute to the “CMC‐Na membrane” film formation and further increase absorption cross‐section for X‐ray radiation owing to the existence of Na elements. The choice of halogen can regulate the photoluminescence of C6H8N2OCuX (X = I, Br, and Cl) from cyan to green and then to yellow, and significant scintillation property can be achieved for C6H8N2OCuI with the light yield of 52 000 photons MeV−1 and detection limit of 43.14 nGy s−1. Finally, the high X‐ray absorption assisted by CMC‐Na, as well as the thin thickness of the composite scintillator films help to realize remarkable spatial resolution above 14 lp mm−1. This study provides a foundation for discovering high‐performance copper(I)‐based halides scintillators and offers a creative think film preparation method for X‐ray imaging.
High‐Temperature Resistant Polyimide Aerogels With Extreme Condition Tolerance Constructed by In Situ Skeleton Encapsulation Growth
Authors: Liu Chun , Wang Mingkang , Zhao Xin , Yang Changpeng , Wei Ran , Zeng Wentao , Ding Feng , Zhang Sizhao , Lei Yongjun 
Published: February 2025

AbstractPolyimide aerogel (PIA) can enable to withstand the extreme conditions in a great measure due to their exceptional thermal stability and excellent mechanical toughness properties derived from the rigid‐ring structures, which are rather promising alternatives in terms of high‐performance thermal protection materials for aerospace field. However, PIA usually suffers from poor dimensional stability at high‐temperature atmosphere, accordingly leading into the degradation of macroscopic features, eventually restricting their extreme‐ambient applications. Here, an in situ skeleton encapsulation growth strategy is proposed to modulate aerogel networking skeleton construction pattern, namely forming the binary organic–inorganic nature skeletons originated from PIA nanoscale structures encapsulated with polymethylsilsesquioxane. The resulting aerogel demonstrates superior dimensional stability (linear shrinkage down to 1.11% even experiencing at 300 °C for 3000 s) despite facing high‐temperature heat flux shock, suggesting an excellent high‐temperature resistant ability depending upon encapsulated Si‐O‐phase‐layer networking skeletons formation and intrinsic strong chemical bonds of polyimide chains. Further, the aerogels own the exceptional extreme‐condition tolerance when subjected to thermal shock cycling (−196 °C—300 °C), and fantastic flame retardancy at 1200 °C. This approach to developing PIA broadens the applicability of high‐performance PIA and holds significant potential for aerospace thermal protection, particularly in extreme conditions.
Muscle soreness but not neuromuscular fatigue responses following downhill running differ according to the number of exercise bouts
Authors: Bontemps Bastien , Louis Julien , Owens Daniel J. , Miríc Stella , Vercruyssen Fabrice , Gruet Mathieu , Erskine Robert M. 
Published: February 2025

AbstractRepeated sessions of eccentric‐biased exercise promote strength gains through neuromuscular adaptation. However, it remains unclear whether increasing the number of these sessions can mitigate the extent of neuromuscular fatigue and exercise‐induced muscle damage (EIMD) in response to a standardised eccentric‐biased bout. Twelve healthy untrained adults (five females and seven males; 25.1 ± 4.9 years; and : 49.4 ± 6.2 mL kg−1 min−1) completed two blocks of five downhill running (DR) sessions on a motorised treadmill at a speed equivalent to 60%–65% for 15–30 min. Knee extensor maximal voluntary isometric torque (MVT), electrically evoked measures of neuromuscular fatigue (peripheral and central components), and lower‐limb perceived muscle soreness (PMS) and perceived load (RPE × session duration) were assessed before and immediately after a 15 min standardised DR bout at baseline and after 5 and 10 DR sessions. MVT decreased following a standardised DR bout (p < 0.01) similarly at all three time points (−14%, −11% and −9%; p > 0.05). The same observations were found for all peripheral and central neuromuscular fatigue indicators after 0, 5 and 10 DR sessions. Quadriceps (but not plantar flexor or gluteus) PMS was lower after 10 DR sessions (8.7 ± 8.5 mm) compared to baseline (29.6 ± 22.2 mm and p = 0.01), but no difference was observed after 5 DR sessions (15.4 ± 11.9 mm and p = 0.08). Ten repeated sessions of eccentric‐biased exercise led to a reduction in quadriceps femoris PMS following a standardised DR bout but neither 5 nor 10 sessions altered the central or peripheral fatigue responses to the same standardised DR bout. These findings suggest distinct physiological adaptations to repeated eccentric‐biased exercise regarding EIMD and neuromuscular fatigue.
OSIRISC: Co-Design of an Integrated Observatory to Monitor Vulnerability to Coastal Risks of Erosion and Marine Flooding in Brittany
Authors: Le Dantec Nicolas , Jaud Marion , Henaff Alain , Le Berre Iwan , Meur-Ferec Catherine , Ruaud Quentin , Rouan Mathias , Pierson Julie , Lummert Caroline , Philippe Manuelle , Lami Thibaud , Letortu Pauline , Guillou Elisabeth , Suanez Serge , Lendre Sylvain 
Published: February 2025

Abstract
OSIRISC is the integrated observatory of systemic vulnerability to coastal risks of erosion and marine flooding in Brittany. OSIRISC approach considers all components of vulnerability: hazards, exposure, risk management and social representations. Using data in various formats, from reference databases and satellite imagery to in situ measurements and surveys with questionnaires, etc., OSIRSIC “measures” these four components over time, with indicators that were co-designed by researchers and risk management stakeholders. Data collection is collaborative, relying both on academics and local risk management authorities, which are involved in the formal partnership Litto’Risques that is meant to enable capacity-building. OSIRISC provides technical and methodological support for collaborative observation and decision-aid for management of coastal erosion and marine flooding risks, as well as training, low-cost instrumentation for field observation protocols, data dissemination through web platforms OSI and MADDOG and networking. The success of OSIRISC observatory relies on the close interaction between academics and local authorities, which requires in-depth involvement of both parties in joint actions (data collection, sharing expertise, …), as well as political support to achieve partnership agreements and engage in long-term observation.
Citizens’ Observatory on Rockfalls in the Madeira Island, Portugal
Authors: Rodrigues Domingos , Gouveia Fátima , Lobo Paulo , Peixoto Ana , Caldeira Nuno , Figueira Rui 
Published: February 2025

Abstract
Natural hazards occur frequently on Madeira Island and their impact can be devastating. Precipitation-triggered hazards including debris flows, landslides and floods, are the main causes of damage and death. Coastal slides and erosion are also important in the region, and earthquakes have also been recorded.
Communication and Dissemination of AGEO
Authors: Ortega Rodríguez A. , Cseko A. , García C. , Cruz Pérez N. , Santamarta Cerezal J. C. , Rodríguez J. S. , Montoya-Montes I. , Galindo Jiménez I. , Sánchez Jiménez N. , López-Davalillo J. C. García , García-Moreno I. 
Published: February 2025

Abstract
Communication was a vital component for AGEO project, as it enabled the Consortium to engage with the stakeholders and raise awareness about geohazards and how to react to them. Bidirectional communication was established with the public, receiving feedback on how to improve the citizens’ preparedness towards geohazards.
Presentation of the Citizens’ Observatory Pilots
Authors: Jaud Marion , Le Dantec Nicolas , Lummert Caroline , Cocquempot Lucie , Montoya-Montes Isabel , Pinto Claudia , Ferreira Mónica Amaral , Parker Kieran , Lemon Kirstin , Rodrigues Domingos , Gouveia Fatima P. , Holohan Eoghan , Correia Vitor , Gomes Rui Carrilho 
Published: February 2025

Abstract
The AGEO project aims to implement five pilots of citizen observatories to improve the monitoring and management of natural hazards in the Atlantic Arc Area, through active participation of stakeholders, local communities and citizens in multiple aspects of risk assessment and prevention. These will be referred to as “pilots” in the following.
Shifts in Composition of Jobs: Upgrading, Downgrading or Polarization? The Case of Russia 2000–2019
Authors: Gimpelson Vladimir , Kapeliushnikov Rostislav 
Published: February 2025

Abstract
In this study, we explore the evolution of the job structure in the Russian economy during the first 20 years of this century. Does it change through a consequent substitution of relatively worse (in terms of quality) jobs by better jobs? Or through the destruction of middle-quality jobs? Or do we observe stagnation and conservation of the job structure? Structural change of this sort can be brought by various factors among which technological progress and international trade that shape demand for labour of different quality and complexity play a special role. In search for clues to these questions, the authors use large data sets that cover two sub-periods divided by the 2008/2009 crisis. The estimates presented in the paper allow rejection of the polarization hypothesis and they document a fast upgrade of the job structure during the first sub-period and a stalemate during the second one. Apparently, risks of job polarization are likely to be minimal until economic growth is recovered and a movement to the technological frontier is accelerated.
Structural Changes in Canadian Employment from 1997 to 2022
Authors: Feor Brittany , Willcox Michael 
Published: February 2025

Abstract
This chapter discusses structural changes in employment and real wages in Canada between 1997 and 2022. The European Jobs Monitor (2017) ‘jobs’ approach reveals a long-term pattern of upgrading, particularly after the 2008 financial crisis. There is variation in these patterns within the 25-year period including a shift towards higher quality jobs after the financial crisis and evidence of wage polarization between 2020 and 2022. Employment and wage trends by sector, sex and age were explored. Employment shifted away from manufacturing towards the healthcare and social assistance, professional, scientific and technical services and construction sectors since the late 1990s which accelerated after the global financial crisis. The wage gap and difference in employment shares between men and women has narrowed over time, despite recent widening following the pandemic. Canada’s ageing population has resulted in a growing share of mature workers in the labour market and in core-age workers becoming more concentrated in mid-to-high wage jobs.
Structural Changes in Brazilian Employment (2002–2021)
Authors: Rodrigues-Silveira Rodrigo 
Published: February 2025

Abstract
This chapter explores the structural changes in employment in Brazil during the period comprehended between 2002 and 2021, subdivided into three sub-periods: 2002–2014, sustained growth and expansion; 2015–2019, political and economic crises; and 2019–2021, the COVID-19 pandemics and its impacts on the labour market. It employs the ‘jobs approach’ (Fernández-Macías, Job polarization in Europe? Changes in the employment structure and job quality, 1995–2007.” Work and Occupations, 39 (2), 157–82, 2012; CEA, Job creation and employment opportunities: The United States labor market, 1993–1996: A report. Washington, D.C.: U.S. Dept. of Labor, Office of the Chief Economist. https://catalog.hathitrust.org/Record/009637143, 1996; Wright & Dwyer, The patterns of job expansions in the USA: A comparison of the 1960s and 1990s. Socio-Economic Review 1 (3), 289–325, 2003) to empirically assess the changes during the period considering wage as the fundamental measure of job quality. The Brazilian National Household Survey (PNAD), administered by the IBGE (Brazilian Statistical Office) since 1976, constitutes the core data source. According to the analysis, since the beginning of the twenty-first century, Brazil has experienced an upgrading in its employment structure. Even considering the macroeconomic and political crises starting in 2015, the advancements observed from 2002 to 2014 were not reverted.
Airways and Inhalational Lung Disease
Authors: Cereghetti Grazia M. , Christe Andreas 
Published: February 2025

Abstract
Airways and inhalational diseases represent a significant portion of respiratory pathologies, with chronic respiratory diseases being the third leading cause of death globally in 2019. Computed tomography (CT), particularly high-resolution CT (HRCT), is the gold standard for diagnosing and assessing airway diseases. HRCT allows visualization of key patterns such as airway wall thickening, bronchiectasis, bronchiolitis, and mosaic perfusion. While chest radiography provides rapid preliminary assessment, especially in emergencies, it has lower sensitivity and specificity compared to CT due to its two-dimensional nature. HRCT is crucial for detecting inhalational lung diseases and diagnosing occupational lung diseases (OLD). This overview presents CT imaging appearances, etiology, pathophysiology, and pathology of various airways and inhalational diseases, including tracheal pathologies. It highlights key diagnostic features and considerations for radiologists, emphasizing the role of HRCT in accurately depicting disease processes in small airways and occasionally leading to specific diagnoses among clinically relevant possibilities.