bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 12724: High Health-Related Quality of Life Among Survivors of Out-of-Hospital Cardiac Arrest: A Nationwide Survey From 2001-2019
Authors: Yonis Harman Gailan Hassan , Sørensen Kathrine Kold , Bøggild Henrik , Bundgaard Ringgren Kristian , Malta Hansen Carolina , Granger Christopher B , Folke Fredrik , Christensen Helle Collatz , Jensen Britta , Andersen Mikkel Porsborg , Joshi Vicky , Zwisler Ann-Dorthe , Torp-Pedersen Christian , Kragholm Kristian 
Published: December 2023

Background:
Survival after out-of-hospital cardiac arrest has increased over the past two decades. However, little is known about the health-related quality of life of long-term survivors.

Purpose:
We conducted a nationwide survey to examine the long-term quality of life of out-of-hospital cardiac arrest survivors from 2001-2019.

Methods:
The study included all out-of-hospital cardiac arrest patients from the Danish Cardiac Arrest Registry between 2001-2019 who were alive in October 2020. Health-related quality of life was evaluated using the EuroQol health questionnaire (EQ-5D), SF-12 Health Survey (SF-12), and Hospital Anxiety and Depression Scale (HADS).

Results:
Of the 4,545 survivors, 2,552 (56.1 %) completed the survey. Respondent and non-respondent age was comparable (67 vs. 68 years). The median EQ-index score for survivors who had been alive for 0-1 year was 0.8 (Q1-Q3: 0.7-1.0), while survivors who had been alive for 15-20 years had a median EQ-index score of 0.9 (0.8-1.0). These scores were comparable to a Danish reference population, whose mean EQ-index score was 0.9 (SD: 0.16).

Mean standardized SF-12 physical health score was 40.6 (SD: 12.7) for 0-1 year survivors vs. 44.4 (SD: 11.8) for >15-20-year survivors, and the SF-12 mental health score was 53.1 (SD: 8.4) vs. 54.1 (SD: 8.7), respectively. Both scores were comparable to a Danish reference population.
In terms of symptoms of anxiety, 73% of survivors who had been alive for 0-1 year reported a normal score (score ≤ 8), compared to 89.3% of survivors who had been alive for 15-20 years. For symptoms of depression, the percentages were 79.7% and 87.5%, respectively (Figure 1).
Health-related quality of life was similar for survivor groups >1-2, >2-4, >4-6, >6-8, >8-10, and >10-15 years after arrest.

Conclusion:
Short-term as well as long-term survivors of out-of-hospital cardiac arrest generally reported high health-related quality of life after the event, regardless of the time elapsed since the arrest.
Abstract 14776: Myopericarditis Mimicking Myocardial Infarction With Non-Obstructive Coronary Arteries
Authors: Akhtar Mohammad M , Bashir Hanad , Menon Santosh 
Published: December 2023

This is a case of a 76-year-old female with a past medical history of recurrent paroxysmal symptomatic supraventricular tachycardia (SVT), atherosclerotic heart disease, mild aortic and mitral valve regurgitation, mild-moderate tricuspid regurgitation, right bundle branch block, hypothyroidism and bronchiectasis who presented to her dermatology appointment with palpitations and dizziness. She visited the cardiologist's office and was found to have SVT on electrocardiogram which did not terminate with Valsalva maneuvers. She arrived at the emergency department with chest pain and converted to sinus rhythm after 6 mg of intravenous adenosine was administered. Her troponin peaked to 0.21 and she was admitted with concerns for non-ST segment elevation myocardial infarction. Transthoracic echocardiogram showed left ventricular ejection fractions of 61 percent with no wall motion abnormalities and left atrial and inferior vena cava dilation. She underwent left heart catheterization which only showed mild calcification and minimal luminal irregularities of the left anterior descending artery. Cardiac MRI showed myopericarditis and she was discharged with 0.6 mg of colchicine twice daily with plans for outpatient follow up.
Discussion
Patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) are discovered to have myocarditis on cardiac MRI 25-30% of time. However, this case uniquely demonstrates myopericarditis as the cause for MINOCA which may not have been previously specified. In addition, it is important to emphasize the utility of Cardiac MRI as a non-invasive modality to diagnose MINOCA “mimics”, especially in the female population.
Abstract 15836: Paraganglioma Presenting as Myocardial Infarction With Decompensated Heart Failure
Authors: Dusi Sashank M , Miller Alec , Kim Julie , Frye Jesse , Chen On 
Published: December 2023

Description of Case: Paragangliomas are extra-adrenal catecholamine secreting tumors, classically presenting with paroxysmal hypertension, headache, and diaphoresis. However, presentations vary significantly, and can mimic cardiac pathologies including myocardial infarction and aortic dissection.
A 52-year-old male with history of hypertension and 1 year of palpitations presented for substernal chest pressure with associated dyspnea, nausea and diaphoresis. He reported two days of cough and nasal congestion, and recent addition of metoprolol for palpitations. His family history was notable for early ACS. On examination, he was tachycardic (140 bpm), hypertensive (220/140 mmHg), and hypoxic requiring non-rebreather mask. EKG revealed sinus tachycardia with 1mm J point elevations in V2 and V3. Chest X-Ray and bedside ultrasound indicated pulmonary edema and reduced systolic function. Nitroglycerin infusion was initiated and he was admitted to the Cardiac ICU. Laboratory testing showed a Troponin-T of 0.15 ng/L (normal <0.01 ng/L), ntPro-BNP 2764 pg/mL, lactic acid 3.2 mmol/L, and respiratory swab positive for Influenza A. A CT Aorta ruled out acute dissection but identified several large retroperitoneal masses. Urgent cardiac catheterization demonstrated non-obstructive CAD. Echocardiography noted severely reduced ejection fraction of 30-35%. With diuresis and alpha blockade, he clinically improved and was discharged. Plasma and urine studies revealed elevated metanephrines. He underwent open paraaortic mass resection and pathology later confirmed paraganglioma.
Discussion: With angina, elevated troponins, and acute decompensated heart failure, this presentation was initially concerning for ACS. However, the absence of obstructive CAD warranted further investigation. While concomitant Influenza A infection raised concern for viral myocarditis, abdominal imaging proved crucial in diagnosing paraganglioma.
The W3C Data Catalog Vocabulary, Version 2: Rationale, Design Principles, and Uptake
Authors: Albertoni Riccardo , Browning David , Cox Simon , Gonzalez-Beltran Alejandra N. , Perego Andrea , Winstanley Peter 
Published: December 2023

ABSTRACT
DCAT is an RDF vocabulary designed to facilitate interoperability between data catalogs published on the Web. Since its first release in 2014 as a W3C Recommendation, DCAT has seen a wide adoption across communities and domains, particularly in conjunction with implementing the FAIR data principles (for findable, accessible, interoperable and reusable data). These implementation experiences, besides demonstrating the fitness of DCAT to meet its intended purpose, helped identify existing issues and gaps. Moreover, over the last few years, additional requirements emerged in data catalogs, given the increasing practice of documenting not only datasets but also data services and APIs. This paper illustrates the new version of DCAT, explaining the rationale behind its main revisions and extensions, based on the collected use cases and requirements, and outlines the issues yet to be addressed in future versions of DCAT.
Effect of weight carriage on work effort in horses
Authors: Munjizun A. , Gluck C. , Walston L. , High K. , Hunter R. , Pratt-Phillips S. 
Published: December 2023

Abstract
Excessive adiposity in horses is associated with equine metabolic syndrome and laminitis, and additional weight due to fat accumulation may cause further stress on the horse. This study aimed to determine the effect of additional weight carriage on work effort in horses, as estimated by changes in heart rate (HR) and body temperature (Temp). Eight mature mixed-breed horses were paired based on body size in a randomised crossover study. Each day tested a pair of horses with one horse carrying additional weight (15% of body weight; to represent approximately 3 body condition scores) and the other horse serving as a control, with treatments reversed the following week. Heart rate was determined before adding the weight, after a 2 h period of stall rest (prior to the exercise bout), and at the end of a 34 min exercise challenge of walking and trotting on an automated exerciser. Temp was recorded prior to exercise and after the horses were removed from the exerciser. Two-way ANOVA was conducted to determine the effect of exercise and weight carriage on HR and Temp, and paired t-tests were used to compare differences in HR and Temp pre- and post-exercise. HR increased with exercise () and was higher following exercise in horses carrying additional weight (). Exercise increased Temp () and the difference in Temp was greater in the weight-carrying group (). This study documents the effect of weight carriage that could be imposed with body fat, in addition to the known health detriments of adiposity.
Research for Peace
Authors: Altekin Okan , Sandal-Wilson Hakan 
Published: December 2023

Abstract
The Diyarbakır-based Cultural Studies for Peace Association (bakad), which was founded in 2021, has been documenting experiences of social inequality with a view to shedding light on the structural and cultural backdrop of these inequalities. Having an explicit intersectional lens, bakad holds a vision of disseminating the culture of peace, and deepening democratic politics in Turkey. This interview, conducted by Hakan Sandal-Wilson, with Okan Altekin on behalf of bakad, provides us with a social and cultural map of Kurdish LGBTI+ inequality and struggles in Diyarbakır and beyond, and their relationship to the complex dynamics of society, peace, conflict, and politics.
The Unruly Books of Abdisho of Nisibis
Authors: Ingeborg Lied Liv 
Published: December 2023

A catalogue as a list, more precisely a book list, is the focus of Liv Ingeborg Lied’s contribution. Lied critically engages scholarship on the list of Old Testament books in Abdisho of Nisibis’s (d. 1318) Syriac Catalogue of the Books of the Church. Focusing on the trajectories in scholarship that have focused on the Christian biblical canon and the lost books of early Judaism, she explores the entries that have proven challenging to this scholarship. The unruly entries of Abdisho’s list fall into three categories: writings that are only known by title and which do not survive as extant and available texts, writings known by multiple titles, and entries that do not comply with the scholarly imagination of an Old Testament book. A new look at the epistemological and ontological status of these categories of entries provides a correction to the treatment of book lists by modern and contemporary scholars and a new appreciation of the many ways of knowing (about) books in a manuscript culture.
Electronic Health Record Stress and Burnout Among Clinicians in Hospital Settings: A Systematic Review
Authors: Alobayli Fatimah , O’Connor Siobhan , Holloway Aisha , Cresswell Kathrin 
Published: December 2023

Background There is growing evidence to suggest that EHRs may be associated with clinician stress and burnout, which could hamper their effective use and introduce risks to patient safety. Objective This systematic review aimed to examine the association between EHR use and clinicians’ stress and burnout in hospital settings, and to identify the contributing factors influencing this relationship. Methods The search included peer-reviewed published studies between 2000 and 2023 in English in CINAHL, Ovid Medline, Embase, and PsychINFO. Studies that provided specific data regarding clinicians’ stress and/or burnout related to EHRs in hospitals were included. A quality assessment of included studies was conducted. Results Twenty-nine studies were included (25 cross-sectional surveys, one qualitative study, and three mixed methods), which focused on physicians (n = 18), nurses (n = 10) and mixed professions (n = 3). Usability issues and the amount of time spent on the EHR were the most significant predictors, but intensity of the working environment influenced high EHR-related workload and thereby also contributed to stress and burnout. The differences in clinicians’ specialties influenced the levels of stress and burnout related to EHRs. Conclusions This systematic review showed that EHR use was a perceived contributor to clinicians’ stress and burnout in hospitals, primarily driven by poor usability and excessive time spent on EHRs. Addressing these issues requires tailored EHR systems, rigorous usability testing, support for the needs of different specialities, qualitative research on EHR stressors, and expanded research in Non-Western contexts.
The Effect of the Corona Virus on the Mental State Among Emergency Room Nurses: A Systematic Review
Authors: Abu Ras Ibrahim Abd Alkariem 
Published: December 2023

Background The COVID-19 pandemic has had a considerable influence on the medical field, especially for emergency room nurses who confront particular difficulties in responding to the crisis in Israel, including possible mental health effects. However, the exact effects of the present epidemic on the mental health of emergency room nurses in Israel remain largely unclear. Aim This study aimed to fill up this knowledge vacuum and advance our understanding of the pandemic’s consequences on the mental health of emergency room nurses in Israel. Methods This study employed the systematic review approach. Only studies published between January 2020 and the time of the search. The studies were searched from various databases such as PubMed, Scopus, CINAHL, Web of Science, and PsycINFO. A thematic analysis technique was used to find common themes among the chosen articles as the systematic review concentrates on the impact of the COVID-19 epidemic on the mental health of emergency room nurses in Israel. A total of 12 studies met the eligibility criteria. Results The main findings are oriented toward the effect of COVID-19 on the mental state of emergency room nurses in Israel. The 12 articles included for this study had various characteristics with majority being cross-sectional studies. Others included multicenter study, questionnaire-based study, and qualitative descriptive study. Using thematic analysis, four dominant themes, such as fear of infection and transmission, increased workload, inadequate support and resources, and coping strategies, emerged from the reviewed literature. Conclusion This systematic analysis emphasizes how crucial it is to consider emergency room nurses’ particular mental health demands during the COVID-19 epidemic.
ZAP-70 augments tonic B-cell receptor and CCR7 signaling in IGHV–unmutated chronic lymphocytic leukemia
Authors: Chen Jingyu , Sathiaseelan Vijitha , Reddy Chilamakuri Chandra Sekkar , Roamio Franklin Valar Nila , Jakwerth Constanze A. , D’Santos Clive , Ringshausen Ingo 
Published: December 2023

Abstract
Expression of ZAP-70 in a subset of patients with chronic lymphocytic leukemia (CLL) positively correlates with the absence of immunoglobulin heavy-chain gene (IGHV) mutations and is indicative of a more active disease and shorter treatment-free survival. We recently demonstrated that ZAP-70 regulates the constitutive expression of CCL3 and CCL4, activation of AKT, and expression of MYC in the absence of an overt B-cell receptor (BCR) signal, bona fide functions of BCR activation. We, here, provide evidence that these features relate to the presence of a constitutive tonic BCR signal, exclusively found in IGHV-unmutated CLL and dependent on the ZAP-70–mediated activation of AKT and its downstream target GSK-3β. These findings are associated with increased steady-state activation of CD19 and SRC. Notably this tonic BCR signal is not present in IGHV-mutated CLL cells, discordantly expressing ZAP-70. Results of quantitative mass spectrometry and phosphoprotein analyses indicate that this ZAP-70–dependent, tonic BCR signal regulates CLL cell migration through phosphorylation of LCP1 on serine-5. Indeed, we show that CCL19- and CCL21-induced chemotaxis is regulated by and dependent on the expression of ZAP-70 through its function to enhance CCR7 signaling to LCP1. Thus, our data demonstrate that ZAP-70 converges a tonic BCR signal, exclusively present in IGHV-unmutated CLL and CCR7-mediated chemotaxis.
Heightened TLR7 signaling primes BCR-activated B cells in chronic graft-versus-host disease for effector functions
Authors: Bracken Sonali J. , Suthers Amy N. , DiCioccio Rachel A. , Su Hsuan , Anand Sarah , Poe Jonathan C. , Jia Wei , Visentin Jonathan , Basher Fahmin , Jordan Collin Z. , McManigle William C. , Li Zhiguo , Hakim Frances T. , Pavletic Steven Z. , Bhuiya Nazmim S. , Ho Vincent T. , Horwitz Mitchell E. , Chao Nelson J. , Sarantopoulos Stefanie 
Published: December 2023

Abstract
Chronic graft-versus-host disease (cGVHD) is a debilitating, autoimmune-like syndrome that can occur after allogeneic hematopoietic stem cell transplantation. Constitutively activated B cells contribute to ongoing alloreactivity and autoreactivity in patients with cGVHD. Excessive tissue damage that occurs after transplantation exposes B cells to nucleic acids in the extracellular environment. Recognition of endogenous nucleic acids within B cells can promote pathogenic B-cell activation. Therefore, we hypothesized that cGVHD B cells aberrantly signal through RNA and DNA sensors such as Toll-like receptor 7 (TLR7) and TLR9. We found that B cells from patients and mice with cGVHD had higher expression of TLR7 than non-cGVHD B cells. Using ex vivo assays, we found that B cells from patients with cGVHD also demonstrated increased interleukin-6 production after TLR7 stimulation with R848. Low-dose B-cell receptor (BCR) stimulation augmented B-cell responses to TLR7 activation. TLR7 hyperresponsiveness in cGVHD B cells correlated with increased expression and activation of the downstream transcription factor interferon regulatory factor 5. Because RNA-containing immune complexes can activate B cells through TLR7, we used a protein microarray to identify RNA-containing antigen targets of potential pathological relevance in cGVHD. We found that many of the unique targets of active cGVHD immunoglobulin G (IgG) were nucleic acid–binding proteins. This unbiased assay identified the autoantigen and known cGVHD target Ro-52, and we found that RNA was required for IgG binding to Ro-52. Herein, we find that BCR-activated B cells have aberrant TLR7 signaling responses that promote potential effector responses in cGVHD.
Association between impaired dynamic cerebral autoregulation and BBB disruption in reversible cerebral vasoconstriction syndrome
Authors: Ling Yu-Hsiang , Chi Nai-Fang , Pan Li-Ling Hope , Wang Yen-Feng , Wu Chia-Hung , Lirng Jiing-Feng , Fuh Jong-Ling , Wang Shuu-Jiun , Chen Shih-Pin 
Published: December 2023

Abstract
Background
Half of the sufferers of reversible cerebral vasoconstriction syndrome (RCVS) exhibit imaging-proven blood-brain barrier disruption. The pathogenesis of blood-brain barrier disruption in RCVS remains unclear and mechanism-specific intervention is lacking. We speculated that cerebrovascular dysregulation might be associated with blood-brain barrier disruption in RCVS. Hence, we aimed to evaluate whether the dynamic cerebral autoregulation is altered in patients with RCVS and could be associated with blood-brain barrier disruption.

Methods
A cross-sectional study was conducted from 2019 to 2021 at headache clinics of a national tertiary medical center. Dynamic cerebral autoregulation was evaluated in all participants. The capacity of the dynamic cerebral autoregulation to damp the systemic hemodynamic changes, i.e., phase shift and gain between the cerebral blood flow and blood pressure waveforms in the very-low- and low-frequency bands were calculated by transfer function analysis. The mean flow correlation index was also calculated. Patients with RCVS received 3-dimensional isotropic contrast-enhanced T2 fluid-attenuated inversion recovery imaging to visualize blood-brain barrier disruption.

Results
Forty-five patients with RCVS (41.9 ± 9.8 years old, 29 females) and 45 matched healthy controls (41.4 ± 12.5 years old, 29 females) completed the study. Nineteen of the patients had blood-brain barrier disruption. Compared to healthy controls, patients with RCVS had poorer dynamic cerebral autoregulation, indicated by higher gain in very-low-frequency band (left: 1.6 ± 0.7, p = 0.001; right: 1.5 ± 0.7, p = 0.003; healthy controls: 1.1 ± 0.4) and higher mean flow correlation index (left: 0.39 ± 0.20, p = 0.040; right: 0.40 ± 0.18, p = 0.017; healthy controls: 0.31 ± 0.17). Moreover, patients with RCVS with blood-brain barrier disruption had worse dynamic cerebral autoregulation, as compared to those without blood-brain barrier disruption, by having less phase shift in very-low- and low-frequency bands, and higher mean flow correlation index.

Conclusions
Dysfunctional dynamic cerebral autoregulation was observed in patients with RCVS, particularly in those with blood-brain barrier disruption. These findings suggest that impaired cerebral autoregulation plays a pivotal role in RCVS pathophysiology and may be relevant to complications associated with blood-brain barrier disruption by impaired capacity of maintaining stable cerebral blood flow under fluctuating blood pressure.

Graphical Abstract
Comparing the efficacy of low-load resistance exercise combined with blood flow restriction versus conventional-load resistance exercise in Chinese community-dwelling older people with sarcopenic obesity: a study protocol for a randomised controlled trial
Authors: Zhuang Min , Shi Jinli , Liu Jian , He Xiangfeng , Chen Nan 
Published: December 2023

Abstract
Introduction
Sarcopenic obesity (SO) is characterised by decreased muscle mass, diminished muscle strength and/or reduced physical performance and a high percentage of body fat (PBF). Conventional-load resistance exercise (CRE) may be difficult for older people with SO owing to their declining physical functions. Low-load resistance exercise (LRE) combined with blood flow restriction (BFR; LRE-BFR) is a viable alternative to CRE for improving muscle mass and strength and potential exercise mode for managing SO. This study has two objectives: (1) to comprehensively evaluate the efficacy of CRE and LRE-BFR in improving body composition, muscle strength, physical performance, haematological parameters, cardiovascular disease (CVD) risk factors and quality of life and (2) to compare the efficacy of CRE and LRE-BFR and explore their potential mechanisms.

Methods and analysis
This work is a 12-week assessor-blinded randomised clinical trial that will be conducted thrice a week. Sarcopenia will be defined using the Asian Working Group for Sarcopenia 2019, and obesity will be determined using the criteria developed by the World Health Organization. Community-dwelling older people aged ≥ 65 years will be screened as the participants using inclusion and exclusion criteria. A total of 33 participants will be randomised into a CRE group (n = 11), an LRE-BFR group (n = 11) and a control group that will be given only health education (n = 11). The primary outcomes will be knee extensor strength and PBF, and the secondary outcomes will be body composition, anthropometric measurements, muscle strength of upper limbs, physical performance, haematological parameters, CVD risk factors and quality of life. The outcomes will be measured at the baseline (week 0), end of the intervention (week 12) and follow up (week 24). All the collected data will be analysed following the intention-to-treat principle.

Ethics and dissemination
The Ethics Research Committee has approved this study (approval No. CMEC-2022-KT-51). Changes or developments in this study will be reported at www.chictr.org.cn.

Trial registration
ChiCTR2300067296 (3 January 2023).