bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Predictive Prompting Improve Future Specialists’ Self evaluation of Communication Skills During End of Life Conversations?
Authors: de Meijer FO , Nyamu N. , Bruin A. 
Published: October 2023

Abstract

In healthcare, effective communication in complex situations such as end of life conversations is critical for delivering high quality care. Whether future specialists learn from communication training with actors depends on whether they are able to select appropriate information or ‘predictive cues’ from that learning situation that accurately reflect their performance and whether they use those cues for ensuing self-judgement. This study aimed to explore whether cue prompts can help residents focusing on predictive cues and improving monitoring accuracy of their communication skills. First and third year Kenyan residents (N = 41) from 8 different specialties were randomly assigned to one of two experimental groups (predictive cue prompt versus control group receiving regular prompts) during a mock OSCE assessing communication skills. The use of predictive cues and the appropriateness of judgements of satisfaction were evaluated against a pre-rated video and compared before and after the intervention and across groups. The intervention improved the use of predictive cues from pre to post test. Ensuing monitoring accuracy only partly improved: no effect from the intervention was found on overall appropriateness of judgements. However, when analyzing participants’ completeness of judgements over the various themes within the consultation, a reduction in inappropriate judgments scores was seen in the intervention group. In conclusion, predictive cue prompts can help learners to concentrate on relevant cues when evaluating their communication skills and partly improve learners’ monitoring accuracy. Future research should focus on offering prompts more frequently to evaluate whether this increases the effect on monitoring accuracy in communication skills.
Assessment of vitamin K2 status in children with chronic kidney diseases
Authors: Sawires Happy , Abdallah Shrouk , Ramadan Mohamed , Abdel-Halim Radwa , Ramadan Yasmin 
Published: October 2023

Abstract
Background : Vitamin K2 plays a crucial role in the formation of osteocalcin in bones, matrix GLa protein in cartilage, and the walls of blood vessels. we aimed to investigate vitamin K2 status in children with CKD G5D, without KRT and after renal transplantation, and its relation to bone turnover by measuring bone turnover marker (bone alkaline phosphatase- BAP). Methods: We enrolled 75 patients classified into 3 groups: group A; CKD without KRT, group B; CKD G5D and group C; renal transplant recipients. Another 25 healthy individuals were involved as a control group. Under carboxylated osteocalcin (uOC) (as a sensitive indicator of vitamin K level) and BAP were measured in fasting blood samples in all patients. 24-hour dietary recall was used to assess vitamin k, calcium, and phosphorus intake. Vitamin and mineral intake was calculated as a percent of target requirements of age and sex-matched healthy children. Results: uOC was found significantly higher in the patient groups in comparison to the control group (p <0.001). The highest level of uOC was detected in the HD group. In all groups except the HD group, robust negative correlations were observed between uOC and both eGFR and vitamin K (%) levels. There was a statistically significant difference in uOC (p < 0.001) between those with history of bone fractures (No.= 7) compared to those without fractures (No.= 93). By logistic regression analysis, increasing uOC was associated with an increased likelihood of exhibiting bone fractures (p = 0.012). Conclusion: elevated uOC levels were observed in children with CKD and demonstrated a correlation with eGFR. Additionally, they exhibited a notable association with heightened bone turnover status, as indicated by BAP levels.
Guidelines for Decolonising Health Sciences Curricula: A Roadmap to Transformation
Authors: Koch Rhea , Pool Jessica , Heymans Yolande 
Published: October 2023

Abstract

South Africa’s complex history with colonialism has left its imprint on the Higher Education Institutions. Decolonisation can address historical injustices and create a more inclusive educational environment. Despite the awareness of its significance, many Higher Education institutions struggle with decolonisation due to varied approaches and resistance. Existing literature highlights a gap in understanding health professions educators' perceptions of decolonisation in health professions education, demanding further research into practical implications. Understanding health professions educators' perspectives is vital, as it influences curriculum design. The aim of this study is to explore how health professions educators at North-West University perceive decolonisation and to use these insights to develop guidelines to inform the decolonising health professions education curricula. To achieve this aim, the study adopted a workshop methodology. Nominal Group Technique was employed within this methodology to encourage meaningful contribution. The study used deductive coding to guide the analysis of collected data. Findings indicate a shift in health professions educators' perceptions of decolonisation when informed discourse and structured guidance are available. Educators require a well-structured plan of action, emphasising the need for practical guidelines to inform decolonisation efforts. The derived guidelines align with the mission of producing healthcare professionals capable of addressing South Africa's diverse healthcare landscape. They facilitate cultural competency and social consciousness among health professions educators, fostering a responsive curriculum transformation and a more inclusive Higher Education environment. This research contributes to the vital discourse on decolonisation by grounding theory in practice, offering practical guidelines as a roadmap to transformation.
Effect of the COVID-19 Pandemic on Utilization of Essential Health Services in Iran Evidence from an Interrupted Time Series Analysis
Authors: Ranjbar Mohammad , Mousavi Seyed Masood , Madadizadeh Farzan , Dargani Nahid Hosseini , Iraji Samaneh , Angell Blake , Assefa Yibeltal 
Published: October 2023

Abstract
Background
The COVID-19 disrupted the provision of essential health services in numerous countries, potentially leading to outbreaks of deadly diseases. This study aims to investigate the effect of the COVID-19 pandemic on the utilization of essential health services in Iran.
Methods
Analytical cross-sectional study was conducted using interrupted time series (ITS) analysis. Data about five indicators, including 'childhood vaccination, infant care, hypertension screening, diabetes screening, and breast cancer screening,' were obtained from the Comprehensive Health Information System in two-time intervals: 15 months before (November 2018 to January 2020) and 15 months after (January 2020 to May 2021) the onset of the COVID-19 pandemic. The data were analyzed by utilizing ITS. In addition, a Poisson model was employed due to the usage of count data. The Durbin-Watson (DW) test was used to identify the presence of lag-1 autocorrelation in the time series data. All statistical analysis was performed using R 4.3.1 software, considering a 5% significance level.
Results
The results the ITS analysis showed that the COVID-19 pandemic significantly affected the utilization of all essential health services (P < 0.0001). The utilization of hypertension screening (RR = 0.51, p < 0.001), diabetes screening (RR = 0.884, p < 0.001), breast cancer screening (RR = 0.435, p < 0.001), childhood vaccination (IRR = 0.947, p < 0.001), and infant care (RR = 1.666, p < 0.001), exhibited a significant decrease in the short term following the pandemic (P < 0.0001). However, the long-term trend for all service utilization, except breast cancer screening (IRR = 0.952, p < 0.001), demonstrated a significant increase.
Conclusions
The COVID-19 pandemic affected utilization of essential health care in Iran. It is imperative to utilize tis evidence to develop policies that will be translated into targeted planning and implementation to sustain provision and utilization of essential health services during public health emergencies. It is also vital to raise awareness and public knowledge regarding the consequences of interruptions in essential health services. In addition, it is important to identify the supply- and demand-side factors contributing to these disruptions.
Construction and Evaluation of Pepper Core Collection Based on Phenotypic Traits and SSR Markers
Authors: Qin Deng , Shuniu Zhao , Congcong Guan , Genying Fu , Shuang Yu , Shisen Lin , Zhiwei Wang , Huizhen Fu , Xu Lu , Shanhan Cheng 
Published: October 2023

Abstract
155 pepper germplasm from different region are used to conduct diversity analysis on 24 phenotypic traits, aiming to reduce the resource conservation workload, improve resource utilization and breeding efficiency. The best core collection was selected from three levels: the proportion of samples within the group, the overall sample size, and the gradual clustering of samples within the group. Representative evaluation of the phenotypic trait data of the core collection was conducted using indicators such as mean, variance, range, and coefficient of variation, and the core collection was confirmed by principal component analysis. At the same time, the Shannon Weaver diversity index and phenotype Shannon index were used to evaluate the representativeness of SSR molecular marker data of germplasm. The results showed that the pepper core collection constructed based on phenotype data contained 41 materials, which were found to perfectly preserved the genetic diversity of the original pepper germplasm using basic genetic parameters and principal component analysis. 54 polymorphic loci were obtained from 155 germplasm using SSR molecular markers, and core collection containing 32 materials was screened. Integrate phenotype and molecular core collection, the core collection composed of 57 varieties with the 92.55% phenotype retention ratio and 100% polymorphism site retention ratio were determined, and had the most genetic diversity according to a 90% compression ratio, which can fully represent the genetic diversity of the original germplasm.
This study, which looks at the effects of transversus abdominis muscle release with bridge supported by a retro-muscular mesh in the posterior component separation used to treat abdominal wall dehiscence, addresses a research gap by retrospective examining multiple hospitals
Authors: Saad Hassan A. , Baz Azza , Riad Mohamed , Eraky Mohamed E , El-taher Ahmed K , Farid Mohamed I , Sharaf Khaled 
Published: October 2023

Abstract
Setting
This investigation looked at the consequences of neuromuscular mesh reinforcing following posterior component separation (CS) and transversus abdominis muscle release (TAR) in patients with primary abdominal wall dehiscence (AWD). The frequency of incisional hernias (IH) at the area of operation following AWD restoration with posterior CS and TAR strengthened by neuromuscular mesh, as well as the potential variables for IH, served as the other goals.
Methods
The time frame for this prospective, multicenter cohort study was April 2015–January 2020. A total of 404 individuals administered posterior CS with TAR release supported by a neuromuscular mesh had median laparotomies and were identified with category IA primary AWD (Björck's first categorization).
Results
The mean age of the group was 42 ± 10 years, with women making up 59.9% of the total. From the midline laparotomy index surgery to the primary AWD, the average time was 7 ± 3 days. The vertical length had an average of 16 ± 2 cm. The average time interval between the onset of AWD and the posterior CS + TAR procedure was 3.1 ± 1 days. The average duration of operation for posterior CS with TAR was 95 ± 12 min. The AWD did not reappear. The percentages of cases with seroma, hemorrhage-contaminated mesh, infection from the surgical site (SSI), and IH were 7.9%, 12.4%, 2%, 8.9%, and 3%, respectively. 2.5% of mortality was recorded in total. Old age, sex, cigarettes, albumin value < 3.5 gm%, SSI, ileus, contaminated mesh, and the time between AWD and posterior CS + TAR with bridge surgery were significantly more common in IH patients. IH rates were 0.5% and 8.9% at 2 and 3 years, respectively. Ileus, SSI, contaminated mesh, and the interval between AWD and posterior CS + TAR operations were identified as variables that indicated IH in multivariate logistic regression analysis.
Conclusions
When posterior CS with TAR and retro-muscular mesh implants were combined, the low mortality rate was 2.5%. Additionally, minimal relapse rates of AWD and IH were noted.
Pancreatic stone protein as a biomarkers for sepsis: a systematic review and meta-analysis
Authors: Zheng Rui , Guo Tongwu , Yang Yuanzheng , Yi Huanying 
Published: October 2023

Abstract
Backgroud
The attack rate of the sepsis and its mortality is increasing rapidly in the world, with early diagnosis and prognosis being essential. Pancreatic stone protein (PSP) is regarded as an excellent indicator of detecting infection, which demonstrated a good diagnostic and prognostic value in sepsis. We utilized the meta-analysis method to further demonstrate the early diagnosis value and prognostic effectiveness of PSP in sepsis.
Methods
Relevant literature was systematically searched in PubMed, Ovid, Embase and ScienceDirect databases using medical subject headings and relevant diagnostic terms. All included literature was analysed using Stata 14.0 to calculate outcomes of pooled extracted data such as sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, area under the curve, diagnostic odds ratio and diagnostic score. Publication bias in the included studies was assessed using Deek's funnel plot. Cochrane Q statistic and I2 statistic were used to test for heterogeneity.
Results
A total of 12 studies were included in this analysis and the literature was divided into three groups based on the type of study: the ability of PSP to diagnose early adult/non-adult sepsis and the ability of PSP to predict mortality outcomes in paediatric sepsis. The combined results of sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, area under the curve, diagnostic odds ratios and diagnostic scores indicated that PSP has good clinical value. No publication bias was found in any of the three meta-analyses.
Conclusions
Diagnosis and prognosis of sepsis by PSP has good accuracy and predictive value that warrants clinical promotion.
Human milk affects TLR4 activation and LPS-induced cytokine expression in Caco-2 intestinal epithelial cells
Authors: Pizzarello Catherine , Nelson Ashley , Verekhman Ilya , Seppo Antti , Jӓrvinen Kirsi 
Published: October 2023

Abstract
Background: Human milk (HM) components affect immune cell toll-like receptor 4 (TLR4) signaling. However, studies examining the immunomodulatory impacts of HM on TLR4 signaling in intestinal epithelial cells (IECs) are limited.
Methods: This study utilized both a TLR4 reporter cell line and a Caco-2 IEC model to examine the effects of HM on lipopolysaccharide (LPS)-induced TLR4 activation and cytokine responses, respectively. Additionally, we performed fast protein liquid chromatography and mass spectrometry to identify a HM component that contributes to the effect of HM on TLR4 signaling.
Results: HM enhances LPS-induced TLR4 signaling as well as IEC gene expression of pro-inflammatory cytokines and negative regulators of NF-κB. Human serum albumin (HSA) present in HM contributes to this effect.
Conclusion: HSA within HM synergizes with LPS to induce TLR4 signaling as well as IEC gene expression of pro-inflammatory cytokines and negative regulators of NF-κB. Altogether, this study provides mechanistic evidence behind the immunomodulatory function of HM on IECs, which may contribute to an enhanced immune response in breast-fed neonates.
The efficiency of biofertilizer and bio-control on root-knot nematode, using bacterial strains, and its effect on tomato plant protein patterns, and improving yield under field conditions
Authors: El-Sawy Sameh , El-Nagdi Wafaa , Mohamed Shereen , Khalil Bigad , Soliman Gaziea 
Published: October 2023

Abstract
Agriculture faces growing population pressure for food security and sustainability. Controlling root-knot nematodes and reducing fertilizer use is crucial for environmental resources preservation. In Egypt, tomato production faces pollution and human health risks by using chemical nematicides to control this nematode. So, PGPRs can improve crop productivity by controlling parasitic nematodes and biofertilization. This experiment was established to study the role of bacterial strains for controlling root-knot nematode, Meloidogyne incognita and saving nitrogen fertilizer in a greenhouse naturally infested nematodes and cultivated by tomato plants. Tomato plants were exposed to foliar spraying and soil drenching of different bacterial strains (fusant F7, Bacillus thuringiensis (Bt), Bacillus cereus (Bc) and Achromobacter xylosoxidans (Ax) compared to chemical nematicide (Oxamyl) for controlling root-knot nematode, M. incognita and saving nitrogen fertilizer (Nitrogen treatments: 30 and 60 N for greenhouse). The modified fusant F7 and its parental strains on M. incognita's nematode reproduction using spraying foliage and soil drench methods. Results showed that all treatments effectively reduced root-knot nematode reproduction, with fusant F7 being more effective in reducing soil parameters like J2, galls, and egg masses. Soil drench achieved the best reduction compared to spraying foliage. Amplification of the protease gene which is reasonable for nematode control from strains Bc and Bt, as well as fusant F7, produced 1100 base pair fragments, confirming gene presence. Results clearly reported that biofertilizer treatments significantly improved all vegetative growth (plant length, number of branches per plant, number of leaves per plant, fresh weights of leaves per plant and dry weights of leaves per plant), flowering and fruit yield (number of clusters per plant, number of fruits per plant, fruit yield) and tomato fruit quality characteristics (average fruit weight, fruit diameter and TSS%) grown under deficit nitrogen treatment. Tomato plants which received the minimum quantity of nitrogen fertilizers (30 N/greenhouse) and treated by fusant F7 as a soil drench produced the highest significant values of vegetative growth, flowering and fruit yield and fruit quality of tomatoes characteristics. SDS-PAGE protein banding patterns to 11 leaves tomato plant treatments varieties for leaf water soluble proteins. The proteins extracted migrated in the 24–191kDa range. In comparison to lesser number 7 bands in the control, the plant exposed to F7 in soil drench spraying showed a highest number of bands (17 bands).
The Effect of Different Traditional Chinese Exercises on Bone Mineral Density in Menopausal Women: A Systematic Review and Network Meta-Analysis
Authors: Hou Jun , Cui Yuemei , Mao Haiping , Rong Ming 
Published: October 2023

Abstract
Objective:
To evaluate the optimal choice of traditional Chinese exercises (TCEs) for improving bone mineral density in postmenopausal women through a network meta-analysis.
Methods:
Chinese and English databases were searched, including China National Knowledge Infrastructure, Chongqing VIP, PubMed, Web of Science and Cochrane Library. The outcomes included BMD of lumbar L2-L4, femoral neck, Ward’s triangle, and greater trochanter. Standardized mean differences (SMD) and 95% confidence intervals (CI) were used to assess the correlation between each group of interventions, and surface under the cumulative ranking (SUCRA) was used to rank the best interventions.
Results:
A total of 20 randomized controlled trials (RCTs) including 1933 subjects and six interventions:( Tai Chi (TC), Baduanjin (BDJ), Wuqinxi (WQX), Yijinjing (YJJ), Tai Chi plus calcium supplementation (TA), and Baduanjin plus calcium supplementation (BA)) were analyzed. Regarding the BMD of the lumbar L2-L4: TC [SMD= 0.99 (0.62,1.37)], BDJ [SMD= 2.12 (1.39,2.85)], TA [SMD= (1.12(0.17,2.07)] and BA [SMD= 2.24 (1.16,3.31)] were superior in increasing BMD of lumbar L2-L4 relative to No exercise intervention (NEI). Regarding the BMD of the femoral neck: TC [SMD= 1.24 (0.70,1.78)] and BA [SMD= 3.77 (1.98,5.56)] were superior in increasing BMD of femoral neck relative to NEI. Regarding the BMD of the ward’s triangle: TC [SMD= 1.63 (1.09,2.17)] was superior in increasing the BMD of the ward’s triangle relative to NEI. Regarding the BMD of the greater trochanter: TC [SMD= 0.98 (0.28,1.68)] was superior in increasing the BMD of the greater trochanter relative to NEI. TC topped the SUCRA with BMD of lumbar L2-L4: 53.8, femoral neck: 74.9, Ward’s triangle:86.9 and greater trochanter: 77.7.
Conclusion:
Four TCEs (TC, BDJ, TA and BA) are all effective in partially improving BMD indicators in postmenopausal women, while TC was effective on all four BMD indicators, which seems to be recommended as the most suitable exercise modality for postmenopausal women.
Klotho plays a role in reno protective effect of allopurinol on renal ischemia-reperfusion injury
Authors: Karimi Zeinab , Ghahramani Pooran , Masjedi Fatemeh , Yavari Vahideh 
Published: October 2023

Abstract
Allopurinol, a xanthine oxidase inhibitor, recovers histological alterations and renal dysfunction induced during renal ischemic-reperfusion injury. This study investigated the cross-talk between the allopurinol and soluble klotho. Method and material: Rats were randomly divided into three equal groups (n = 8 per group): The sham-operated group without renal ischemia, the BIR (bilateral ischemia-reperfusion) group which underwent renal ischemia, and the BIR + Allo (allopurinol) group which was pretreated with allopurinol (100 mg/kg- gavage) 30 min before BIR. After recovery from the anesthesia, all animals were placed in metabolic cages to collect their urine in 24h. After 24 h, plasma was extracted from a blood sample, which was taken from the tail vein. Plasma and urine samples were saved at -20oC. Kidneys were harvested and weighed. The left kidney was dropped in the buffer of 10% formalin for H&E staining, and the right kidney was located in liquid nitrogen and saved at 80oC for the oxidative stress analysis. Results: After renal ischemia–reperfusion, serum creatinine, blood urea nitrogen, xanthine oxidase, and total oxidative stress levels significantly increased. However, plasma klotho level and total antioxidative capacity decreased in the BIR group. There was a reverse correlation between klotho and xanthine oxidase levels. The pretreatment with allopurinol increased plasma Klotho and induced a protective effect on renal histopathological changes and corrected functional biomarkers. Conclusion: Our result showed that allopurinol enhanced its antioxidative effect by increasing klotho activity. Therefore, Klotho may be involved in the protective effects of allopurinol on the renal injury induced by BIR.