bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Callisphere Drug-Eluting Beads Transarterial Chemoembolization and Conventional Transarterial Chemoembolization for the treatment of Hepatocellular Carcinoma
Authors: Ren Yongjun , Zhao Caixia , Xiong Yongfu , Liu Zhongbai , Wu Guo 
Published: December 2023

Objective: To compare the efficacy of CalliSphere drug-eluting beads (DEBs) and conventional (c) transarterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC).
Methods: We retrospectively reviewed the clinical data of 125 patients with HCC who had received treatment in Affiliated Hospital of North Sichuan Medical College from January 2018 to February 2019. Sixty-one patients underwent DEB-TACE (observation group) and 64 patients underwent cTACE (control group). The clinical efficacies, overall survivals, and incidence of postoperative adverse reactions between the two groups were compared.
Results: The objective response rate in the observation group (85.25%) was higher than that in the control group (70.31%; P<0.05). The disease control in the observation group (96.72%) was higher than that in the control group (85.94%; P<0.05). The median survival time of the observation group (24.85 months) was significantly higher than that in the control group (18.18 months; P<0.05). The incidence of adverse reactions in the observation group (4.92%) was lower than that in the control group (17.19%, P<0.05).
Conclusions: In the treatment of HCC, Callisphere DEB-TACE has better efficacy and longer patient survival with fewer adverse reactions compared to cTACE.
doi: https://doi.org/10.12669/pjms.40.3.8572
How to cite this: Ren Y, Zhao C, Xiong Y, Liu Z, Wu G. Comparison of Callisphere Drug-Eluting Beads Transarterial Chemoembolization and Conventional Transarterial Chemoembolization for the treatment of Hepatocellular Carcinoma. Pak J Med Sci. 2024;40(3):---------. doi: https://doi.org/10.12669/pjms.40.3.8572
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The efficacy of extracorporeal shock wave combined with platelet rich plasma in the treatment of knee osteoarthritis with meniscus injury: A retrospective analysis
Authors: Li Jin , Li Jie , Li Dan , Jin Xi , Liu Sheng , Zhang Liheng 
Published: December 2023

Objective: To determine the efficacy of extracorporeal shock wave (ESW) combined with autologous platelet-rich plasma (PRP) therapy on knee osteoarthritis (KOA) with meniscus injury in terms of pain relief, functional outcome and complications.
Methods: This is a retrospective observational study. Clinical data of 144 patients with KOA accompanied by medial meniscus injury, who received treatment in Jilin Provincial People’s Hospital from March 2021 to December 2022, were retrospectively evaluated. A total of 128 patients (81 males and 47 females) were finally included in the study after screening. Of them, 45 patients received PRP treatment (PRP-group), 43 patients received ESW treatment (ESW-group), and 40 patients received ESW combined with PRP treatment (Combined-group). The relief of knee joint pain and functional improvement among three groups of patients were compared.
Results: After treatment, visual analogue scale (VAS), Lequesne, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores of patients in the Combined-group were significantly lower than those in the other two groups (p<0.05). Combined ESW-PRP treatment was associated with significantly greater joint range of motion of patients compared to ESW and PRP alone (p<0.05). The total incidence of related complications in the Combined-group was lower compared to the other two groups (p<0.05).
Conclusions: Compared with PRP or ESW treatment alone, ESW combined with PRP for KOA with meniscus injury can better alleviate pain, achieve faster functional recovery, and significantly reduce complications.
doi: https://doi.org/10.12669/pjms.40.3.8670
How to cite this: Li J, Li J, Li D, Jin X, Liu S, Zhang L. The efficacy of extracorporeal shock wave combined with platelet rich plasma in the treatment of knee osteoarthritis with meniscus injury: A retrospective analysis. Pak J Med Sci. 2024;40(3):---------. doi: https://doi.org/10.12669/pjms.40.3.8670
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Effect of calcium plus Vitamin-D combined with calcitriol in the treatment of patients with Type-2 diabetes and osteoporosis: A retrospective observational analysis
Authors: Wan Jinxing , Xie Jun , Hu Chaohui , Liu Jiahe , Zhu Chunyan 
Published: December 2023

Objective: To explore the clinical effect of calcium plus Vitamin-D combined with calcitriol in the treatment of patients with type-2 diabetes mellitus (T2DM) patients and osteoporosis.
Methods: In this retrospective observational study clinical records of 90 patients with T2DM combined with osteoporosis, treated in The Quzhou Affiliated Hospital of Wenzhou Medical University from October 2019 to April 2022 were incuded. All patients received basic hypoglycemic treatment. Of 90 patients, 43 received calcium plus Vitamin-D adjuvant therapy (Control-group), and 47 patients received calcium plus Vitamin-D combined with calcitriol adjuvant therapy (Observation-group). Clinical efficacy, adverse reactions, bone metabolism levels, and changes in bone density levels were compared between the two groups.
Results: The clinical efficacy of the treatment was significantly higher in the Observation-group (93.6%) compared to the Control-group (83.7%; p<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (p>0.05). After treatment, bone metabolism and bone density indicators in both groups improved, and were significantly better in the Observation-group compared to the Control-group (p<0.05).
Conclusions: Combination of calcium plus Vitamin-D and calcitriol adjuvant therapy in patients with T2DM and osteoporosis is safe and associated with better treatment efficacy, improved bone metabolism and bone density parameters than calcium plus Vitamin-D treatment alone.
doi: https://doi.org/10.12669/pjms.40.3.8795
How to cite this: Wan J, Xie J, Hu C, Liu J, Zhu C. Effect of calcium plus Vitamin-D combined with calcitriol in the treatment of patients with Type-2 diabetes and osteoporosis: A retrospective observational analysis. Pak J Med Sci. 2024;40(3):---------. doi: https://doi.org/10.12669/pjms.40.3.8795
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Critical contingency competition in L2 clause positioning acquisition: the case of concessive clause by Chinese EFL learners
Authors: Xu Jiajin , Kang Hui 
Published: December 2023

Abstract
Concessive clause positioning as a result of multi-cue competition has been widely examined in L1 and L2 English learners. This study furthers the present research by examining competition patterns among contingency, L1 transfer, and salience factors in concessive clause positioning by Chinese EFL learners. We extracted 1,356 concessive subordinations conjoined by although and though from native and learner argumentative essays, and used multifactorial models to examine the effectiveness, tuning tendency, and power ranking of the cues that tune concessive clause positions. A critical contingency competition was tentatively concluded in concessive clause positioning by Chinese EFL learners. That is, in cue consistency across native and learner datasets, contingency values assume the baseline role, which L1 transfer hinders while salience promotes. In addition, a critical contingency value exists, above which L1 transfer effects are not stronger than contingency and salience effects, so that cue consistency would usually be maintained and vice versa.
Exploring multilingual writers in secondary education: insights from a trilingual corpus
Authors: Arias-Hermoso Roberto , Imaz Agirre Ainara 
Published: December 2023

Abstract
This study aims at contributing to the field of multilingual writing and providing evidence for Cummins’ Common Underlying Proficiency Hypothesis (CUP) through analysing trilingual writing among secondary education students enrolled in a Basque immersion program. The main objective of the present study is to explore the relationships between participants’ compositions in their three languages of schooling (Basque, Spanish and English). A trilingual corpus of argumentative scientific writing essays was collected from a sample of 113 secondary education students. The texts were analysed with MultiAzterTest to retrieve complexity, accuracy and fluency measures. Correlational analyses were performed to explore correlations of each measure across languages, and low-moderate correlations were found between most measures and their counterparts. Specifically, accuracy and fluency measures showed stronger between-language relationships, which were especially salient between Basque and Spanish. Findings suggest that multilingual learners exhibit similar across-language patterns in the writing process, thus supporting Cummins’ CUP. The emerging similarities have important implications for bi/multilingual education programs, as they might inform curriculum design and instruction to foster crosslinguistic transfer and metalinguistic multilingual awareness.
Predicting copper-polymetallic deposits in Kalatag using the weight of evidence model and novel data sources
Authors: Xi Wei , Ping YuanYe , Tao JinTao , Liu Chaoyang , Shen Junru , Zhang YaWen 
Published: December 2023

Abstract
The Kalatag Ore Cluster Area, located in the Eastern Tianshan metallogenic belt of Xinjiang, stands out as a notable copper polymetallic mineralization zone, recognized for its diverse ore types and untapped potential. Despite the foundational nature of traditional exploration methods, they have not fully exploited this potential. Addressing this, our study leverages modern geospatial technologies, especially ArcGIS, combined with multi-source geoscience data to refine ore formation predictions in Kalatag. We identified key ore-controlling factors: the ore-bearing strata of Daliugou and Dananhu Groups, buffer zones around faults and intrusions, and geophysical anomalies. From these, a conceptual model was developed using the weight of evidence model. This model pinpointed four ‘A’ class and three ‘B’ class targets for mineral exploration, highlighting the central role of faults in ore control. Significantly, all known ore deposits were encompassed within these targets. Our approach not only paves the way for improved ore prediction in Kalatag but also offers a blueprint for other mineral-rich areas. Merging traditional geology with advanced technology, we elevate mineral exploration’s precision, emphasizing the synergy of an integrated method, especially in geologically complex areas. The effectiveness of our model provides insights for future exploration, particularly in mining areas’ deeper zones.
Association between diet, mental health and sleep quality in university students during the COVID-19 pandemic: a systematic review
Authors: Candia Constanza Díaz , Miranda Camila Risco , Durán-Agüero Samuel , Johns Priscila Candia , Díaz-Vásquez Waldo 
Published: December 2023

Abstract

Objectives
To evaluate recently published scientific evidence and synthesize the results of observational studies that examine the association between diet, mental health, and sleep quality in university students during the COVID-19 pandemic.

Content
An electronic search of scientific literature published in 2021 and up to 2 years ago was performed using keyword search, with focus on observational studies published in PubMed, MEDLINE and Web of Science. It included: active university students of both sexes during the COVID-19 pandemic.

Summary and Outlook
The 5 studies included in this review showed that there have been significant changes in both mental health and eating habits during the COVID-19 pandemic. The conclusion, there is an association between mental health and sleep quality in university students, resulting in an alteration of sleep hours and poor sleep. Furthermore, an association between mental health and diet quality is also observed, producing an increase in caloric intake or in the number of meals during the day.
Investigation of aroma profiles, textural, rheological, and sensorial qualities of yogurts with various starter cultures and goat–cow milk combinations
Authors: Terzioğlu Murat Emre , Bakirci İhsan 
Published: December 2023

Abstract
In the present study, aroma components, textural, rheological and sensory qualities of yogurts produced using YC-350 and ABT-2 starter cultures and combinations of goat/cow milk were investigated during the storage period. For this purpose, aroma components were analyzed by GC-MS, textural analyses by TA.XTplus Texture Analyzer and rheological analyses by Anton Paar MCR 102 rheometer. The effects of goat/cow milk combinations and variety of starter culture on aroma components, textural, rheological and sensory properties of yogurt samples were found significant (p < 0.01). Also, the storage period significantly (p < 0.01) affected all parameters tested except cohesiveness, resilience, and appearance. While it was found that the use of cow milk in the experimental yogurt samples increased the acetaldehyde content, it was found that it had varying effects on the diacetyl content, acetoin content, and textural and rheological analysis parameters. It was determined that the content of diacetyl and acetoin reduced with the progression of the storage times. In the sensory evaluations, the use of goat milk had positive effects on the parameters of appearance and consistency by spoon, and the use of probiotic culture (ABT-2) had positive effects on the parameters of consistency by mouth and overall acceptability.
Understanding poverty through virtual simulation: implications for student clinical practice
Authors: Morgan Lindsay , McNiel Paula , Koplitz Jodi 
Published: December 2023

Abstract

Background
Competency-based education among baccalaureate nursing students is emerging based on American Association of Colleges of Nursing Essentials. With the impact of COVID-19 on nursing education and AACN recommendations, changes were required to provide alternative modes of delivery and means of assessment.

Purpose
Virtual poverty simulation data is limited. The use of virtual poverty simulation will ensure students’ mastery of core competencies while offering versatility in an online environment.

Methods
Students virtually completed online pre-work, SPENT, a virtual poverty simulation, online debriefing, post-simulation assessment using the Simulation Effectiveness Tool, and post-simulation journaling.

Results
94 % of students demonstrated improved clinical decision making, increased confidence in prioritizing care, communication and reporting, and fostering patient safety. Four themes were identified from journals.

Conclusions
The use of virtual poverty simulation with baccalaureate nursing students was identified as useful pedagogy for increasing student understanding of health implications related to poverty in a virtual learning environment.
Comorbidities associated with symptoms of subjective cognitive decline in individuals aged 45–64
Authors: Monahan Zach , Heath Jacob , Santos Alexis Ditren , Ford Alicia , Hartwell Micah 
Published: December 2023

Abstract

Context
Early-stage cognitive decline occurs when an individual experiences memory loss or other cognitive impairment but does not meet the criteria for Alzheimer’s disease (AD) or other dementias. After diagnosis of mild cognitive impairment (MCI), approximately 5–15 % of cases progress to dementia per year. AD and many other causes of dementia are presently incurable. Early recognition of cognitive decline can allow healthcare providers to reduce the risk of disease progression. Literature is scarce on factors that can increase the incidence of cognitive decline, especially in early ages; this is further exacerbated by difficulty tracking the prevalence of mild cognitive symptoms.

Objectives
This analysis aims to determine demographic and comorbid factors that predispose individuals to higher rates of early-stage subjective cognitive impairment in order to determine which individuals should be screened at earlier stages.

Methods
We conducted a cross-sectional analysis of data from the Subjective Cognitive Decline module of the 2017–2021 Behavioral Risk Factor Surveillance System (BRFSS). Applying survey design and sampling weights, we constructed binary logistic regression models to assess associations, via odds ratios (OR), between comorbidities and subjective cognitive decline (SCD). Alpha was set at 0.05 and confidence intervals (CIs) are reported at 95 %.

Results
Our sample included 110,305 participants representing 13.4 million US adults aged 45–64 years. Results showed that individuals with diabetes (OR: 2.29, CI: 2.09–2.51), hypertension (OR: 1.98, CI: 1.81–2.17), stroke (OR: 4.61, CI: 4.07–5.22), myocardial infarction (MI [OR: 3.09, CI: 2.73–3.49]), coronary heart disease (CHD [OR: 3.26, CI: 2.88–3.69]), depression (OR: 5.65, CI: 5.21–6.11), and chronic kidney disease (CKD [OR: 3.08, CI: 2.66–3.58]) experienced higher rates of SCD. Further, there were higher rates of SCD among individuals who identified as American Indian/Alaskan Native (AI/AN), those with low educational attainment, and those with lower incomes.

Conclusions
Our findings show that all comorbidities listed were correlated with higher rates of memory loss or confusion. Investigation of factors that are associated with an increased risk of developing new or worsening cognitive decline allows healthcare professionals to properly screen and treat these individuals early, before progressing to conditions that are currently incurable. Future studies into the mechanisms of these diseases in contributing to cognitive decline can illuminate specific effective treatment options.
Global well-posedness of initial-boundary value problem of fifth-order KdV equation posed on finite interval
Authors: Zhao Xiangqing , Wang Chengqiang , Bao Jifeng 
Published: December 2023

Abstract
We have established the existence and uniqueness of the local solution for
(0.1)

∂

t

u
+

∂

x

5

u
−
u

∂

x

u
=
0
,

0
<
x
<
1
,

t
>
0
,

u

(

x
,
0

)

=
φ

(

x

)

,

0
<
x
<
1
,

u

(

0
,
t

)

=

h

1

(

t

)

,
u

(

1
,
t

)

=

h

2

(

t

)

,

∂

x

u

(

1
,
t

)

=

h

3

(

t

)

,

∂

x

u

(

0
,
t

)

=

h

4

(

t

)

,

∂

x

2

u

(

1
,
t

)

=

h

5

(

t

)

,

t
>
0
,

\left\{\begin{array}{ll}{\partial }_{t}u+{\partial }_{x}^{5}u-u{\partial }_{x}u=0,& 0\lt x\lt 1,\hspace{1.0em}t\gt 0,\\ u\left(x,0)=\varphi \left(x),& 0\lt x\lt 1,\\ u\left(0,t)={h}_{1}\left(t),u\left(1,t)={h}_{2}\left(t),\hspace{0.33em}{\partial }_{x}u\left(1,t)={h}_{3}\left(t),& \\ {\partial }_{x}u\left(0,t)={h}_{4}\left(t),\hspace{0.33em}{\partial }_{x}^{2}u\left(1,t)={h}_{5}\left(t),& t\gt 0,\end{array}\right.

in the study of Zhao and Zhang [Non-homogeneous boundary value problem of the fifth-order KdV equations posed on a bounded interval, J. Math. Anal. Appl. 470 (2019), 251–278]. A question arises naturally: Can the local solution be extended to a global one? This article will address this question. First, through a series of logical deductions, a global a priori estimate is established, and then the local solution is naturally extended to a global solution.
On pomonoid of partial transformations of a poset
Authors: Al Subaiei Bana 
Published: December 2023

Abstract
The main objective of this article is to study the ordered partial transformations

PO

(

X

)

{\mathcal{PO}}\left(X)

of a poset

X

X

. The findings show that the set of all partial transformations of a poset with a pointwise order is not necessarily a pomonoid. Some conditions are implemented to guarantee that

PO

(

X

)

{\mathcal{PO}}\left(X)

is a pomonoid and this pomonoid is denoted by

PO

↑

(

X

)

{{\mathcal{PO}}}^{\uparrow }\left(X)

. Moreover, we determine the necessary conditions in order that the partial order-embedding transformations define the ordered version of the symmetric inverse monoid. The findings show that this set is an inverse pomonoid and we will denote it by

ℐPO

↑

(

X

)

{{\mathcal{ {\mathcal I} PO}}}^{\uparrow }\left(X)

. In case the order on the poset

X

X

is total, we explore some properties of

PO

↑

(

X

)

{{\mathcal{PO}}}^{\uparrow }\left(X)

and

ℐPO

↑

(

X

)

{{\mathcal{ {\mathcal I} PO}}}^{\uparrow }\left(X)

, including regressive, unitary, and reversible.
ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
Authors: Wu Xiujuan , Shen Shuijuan , Wu Jiaying , Wu Shaorui , Wang Shimi , Di Feng 
Published: December 2023

Abstract
This study aims to investigate the impact of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) on vascular calcification in rats. The rationale behind studying ENPP1’s role in vascular calcification lies in its potential to modulate calcification processes. Understanding this relationship can offer insights into novel therapeutic avenues for addressing vascular calcification-related disorders. In this experiment, vascular smooth muscle cell (VSMC) calcification was induced using β-glycerophosphoric acid. Subsequently, recombinant AAV9-carrying ENPP1 was introduced into VSMCs to achieve both in vitro and in vivo overexpression of ENPP1. The findings indicate that ENPP1 overexpression significantly reduces calcium and phosphorus content in the aorta (P < 0.05). Alizarin red and von Kossa staining reveal notable reductions in calcium salt deposits in VSMCs and aorta, respectively. Notably, the expression levels of BMP-2, PINP, OC, and BALP were substantially decreased in VSMCs (P < 0.05), underscoring ENPP1’s role in impeding osteoblast-like transdifferentiation of VSMCs. Additionally, ENPP1 overexpression led to a significant increase in pyrophosphate (PPi) levels compared to control rats (P < 0.05). In conclusion, this study suggests that ENPP1 contributes to alleviating vascular calcification by elevating PPi levels and inhibiting the phenotypic transformation of VSMCs. These findings shed light on the potential therapeutic role of ENPP1 in mitigating vascular calcification-related complications.