bluuebunny/crossref_metadata_2025_split huggingface dataset:
(Epi)genetic and clinical characteristics in 84 patients with pseudohypoparathyroidism type 1B
Authors: Urakawa Tatsuki , Sano Shinichiro , Kawashima Sayaka , Nakamura Akie , Shima Hirohito , Ohta Motoki , Yamada Yuki , Nishida Ai , Narusawa Hiromune , Ohtsu Yoshiaki , Matsubara Keiko , Dateki Sumito , Maruo Yoshihiro , Fukami Maki , Ogata Tsutomu , Kagami Masayo 
Published: November 2023

Abstract

Objective
Pseudohypoparathyroidism type 1B (PHP1B) caused by methylation defects of differentially methylated regions (DMRs) on the GNAS locus can be categorized into groups according to etiologies and methylation defect patterns of the DMRs. The aim of this study was to clarify the clinical characteristics of each group.

Design
Comprehensive molecular analyses consisting of methylation, copy number, and microsatellite analyses.

Methods
Eighty-four patients with PHP1B were included in this study. We classified them into 5 groups, namely, autosomal dominant inheritance-PHP1B (Group 1, G1), sporadic-PHP1B (G2), and atypical-PHP1B (G3-G5), based on the methylation defect patterns in 4 DMRs on the GNAS locus and etiologies and evaluated the clinical findings in each group and compared them among the groups.

Results
G2 had the youngest age and the highest serum intact parathyroid hormone levels among the 5 groups at the time of diagnosis. The most common symptoms at the time of diagnosis were tetany in G1, and seizures or loss of consciousness in G2. Albright's hereditary osteodystrophy and PHP-suggestive features were most frequently observed in the G2 proband. Nine patients had neurodevelopmental disorders (NDs) consisting of mild to borderline intellectual disability and/or developmental delay. There were no significant correlations between the average methylation ratios of 7 CpG sites in the GNAS-A/B:TSS-DMR and hormonal and biochemical findings.

Conclusion
This study revealed the differences in some clinical characteristics, particularly clinical features, and ages at the time of diagnosis between G2 and other groups and detailed NDs observed in some patients with PHP1B.
Factors associated with vaccine adherence among an underserved population: the adult Travellers in Nouvelle-Aquitaine, France
Authors: Haidar Sahar , Richard Elodie , Vaux Sophie , Allaire Cecile , Castor Christine , Levy Bruhl Daniel , Mondeilh Aude , Vandentorren Stéphanie 
Published: November 2023

Abstract

Background
A measles epidemic affected the Nouvelle-Aquitaine region from November 2017 to May 2018 with clusters among Travellers. This indicates that measles vaccination rates among Travellers remain lower than in the general population. The objective of this study was to estimate the ‘declarative vaccination’ against measles, mumps and rubella (MMR) and to propose a conceptual framework to help identify determinants of MMR vaccination uptake among adult Travellers in Nouvelle-Aquitaine in 2019–20.

Methods
A cross-sectional study using random sampling was performed and included 612 adult Travellers from 1 November 2019 to 31 March 2020. A conceptual framework to model vaccination adherence was tested among this underserved population by using structural equation modelling. This model included five latent variables: health literacy, attitudes toward preventive measures, stigma, accessibility to care and perceived needs and five measured variables: information received on vaccination, perception of barriers, support for administrative documents, social support and housing conditions.

Results
Individuals who did not answer all the questions linked to the variables included in the model were excluded, thus 347 adults were included in the final sample. The declared vaccination rate against MMR was 74.0%, and 72.4% of the participants were favorable to vaccination. Vaccination adherence was significantly correlated with favorable attitudes toward preventive measures such as having a history of MMR vaccination and not having already refused a recommended vaccine and finally satisfactory information received on vaccination.

Discussion
To improve vaccination adherence, health authorities should lean on personal history with vaccination and on transmitting information on vaccination.
Bordetella pertussis targets the basolateral membrane of polarized respiratory epithelial cells, gets internalized, and survives in intracellular locations
Authors: Baroli Carlos Manuel , Gorgojo Juan Pablo , Blancá Bruno Martín , Debandi Martina , Rodriguez Maria Eugenia 
Published: November 2023

Abstract
The airway epithelial barrier is a continuous highly organized cell layer that separates the exterior from the underlying mucosal tissue, preventing pathogen invasion. Several respiratory pathogens have evolved mechanisms to compromise this barrier, invade and even reside alive within the epithelium. Bordetella pertussis is a persistent pathogen that infects the human airway epithelium, causing whooping cough. Previous studies have shown that B. pertussis survives inside phagocytic and nonphagocytic cells, suggesting that there might be an intracellular stage involved in the bacterial infectious process and/or in the pathogen persistence inside the host. In this study we found evidence that B. pertussis is able to survive inside respiratory epithelial cells. According to our results, this pathogen preferentially attaches near or on top of the tight junctions in polarized human bronchial epithelial cells and disrupts these structures in an adenylate cyclase-dependent manner, exposing their basolateral membrane. We further found that the bacterial internalization is significantly higher in cells exposing this membrane compared with cells only exposing the apical membrane. Once internalized, B. pertussis mainly remains in nondegradative phagosomes with access to nutrients. Taken together, these results point at the respiratory epithelial cells as a potential niche of persistence.
Identifying and Prioritising the Causes of Medication Errors in the Pharmacy
Authors: Arslan M , Kağanoğlu İ 
Published: November 2023

Abstract

Introduction
Medication errors can negatively impact the health of numerous individuals worldwide and even lead to fatalities, from incorrect timing, dosages, or methods of administration of drugs to mismanagement of drug interactions. Such errors can arise from patients and healthcare professionals in all stages of patient care. Therefore, all healthcare workers must pay attention to preventing medication errors, correctly managing encountered errors, and reporting them appropriately to ensure patient safety. Parallel to these, one of the FIP's development goals for pharmacists was also determined as Patient Safety. Despite various studies that have analysed medication errors from different perspectives, no study has thoroughly evaluated the causes of medication errors specific to community pharmacists.

Aim
This project aimed to identify and prioritise the causes of medication errors encountered in community pharmacies.

Methods
According to the aim of the study, semi-structured qualitative interviews were conducted with 16 community pharmacists in Van. Thematic analysis was conducted on the qualitative interview findings. Additionally, at the end of the qualitative interviews, a questionnaire was applied due to the Analytical Hierarchy Process (AHP), to prioritize the causes of the medication errors.
This study was conducted after Van Yüzüncü Yıl University Non-interventional Research Ethics Committee approved the study ethically (Date:18/11/2022, Decision No: 2022/11-25). This study is supported by The Scientific and Technological Research Council of Türkiye (TUBITAK)’s 2209/2022 2nd term projects (Project No: 1919B012217783).

Results
Three main themes and 13 sub-themes were obtained. The study's results emphasise that communication gaps and manual prescriptions are the most significant causes of medication errors reported by pharmacists. As a result of the AHP, prescription errors (31.5%) were found to be the most encountered reason for medication errors, followed by medication knowledge gaps (25.7%).

Discussion/Conclusion
Pharmacists, aware of their responsibilities for patient and drug safety, also have an essential role in solving problems that cause medication errors. With this study, it is also seen that pharmacists show the necessary self-sacrifice and take precautions to minimize medication errors originating from the pharmacy. So, the findings obtained from this study are thought to have guiding implications for preventing medication errors.
A Single-Laboratory Validation of a UPLC Method for Determination of Folic Acid in Various Dietary Supplement Dosage Forms
Authors: A Lusi , Fakhary Mina , Gaeini Niloufar Rahimi , Solano Jennifer M , Koroma Mohamed 
Published: November 2023

Abstract

Background
Folic acid is an essential nutrient necessary for the synthesis of nucleic acids (DNA and RNA) and certain amino acids. There are no scientifically validated analytical methods for folic acid applicable to all dosage forms.

Objective
A single-laboratory method was validated for the determination of folic acid content in various dietary supplement dosage forms. This method used ultra-performance liquid chromatography/diode-array detector (UPLC/PDA) to determine the folic acid content in dietary supplements in the form of tablets, two-piece capsules, powder drinks, softgels, and gummies.

Method
The ultra-performance liquid chromatography/diode-array detector method was evaluated for linearity, limit of detection (LOD), limit of quantification (LOQ), repeatability, recovery, specificity, and system suitability.

Results
Linearity of the folic acid standard was shown to be linear in the range of 0.45 µg/mL to 7.37 µg/mL. LOD and LOQ of folic acid were 0.089 and 0.268 µg/mL, respectively. The repeatability of nine samples from five matrixes resulted in 1.15–4.82% relative standard deviation (RSD). Five samples with five different matrixes spiked with 25, 50, and 100% of working standard concentration and had a recovery range of 95.48–104.72%. The chromatograms and spectra of the blank, standard, and sample solutions showed that the method was free of interference for folic acid. The system suitability results of different matrixes showed that the UPLC/PDA system is suitable for folic acid analysis. All the AOAC INTERNATIONAL SMPR® 2022.002 requirements were fulfilled.

Conclusions
The ultra-performance liquid chromatography/diode-array detector method compares favorably with the requirements of AOAC SMPR 2022.002.

Highlights
The UPLC/PDA method is fast and suitable for all dietary supplement matrixes studied. The method meets the requirements of SMPR 2022.002.
Maternal exercise during pregnancy modulates genotoxicity caused by high fructose consumption in mice offspring
Authors: Magenis Marina Lummertz , Damiani Adriani Paganini , Monteiro Isadora de Oliveira , Dagostin Ligia Salvan , Silva Nicollas dos Santos , Scussel Rahisa , Nagashima Seigo , Langie Sabine A S , Pinho Ricardo Aurino , de Andrade Vanessa Moraes 
Published: November 2023

Abstract
Pregnancy is a period that is characterized by several metabolic and physiological changes and requires special attention, especially with regard to the relationship between feeding and foetal development. Therefore, the objective of this study was to evaluate whether the practice of voluntary physical exercise (VPE) in combination with chronic consumption of fructose (FRU) from the beginning of life and/or until the gestational period causes genotoxic changes in pregnant females and in their offspring. Seventy Swiss female mice received FRU in the hydration bottle and/or practiced VPE for 8 weeks (prepregnancy/pregnancy). After the lactation period, the offspring groups were separated by sex. It was observed that the consumption of FRU affected the food consumption, serum concentration of FRU, and glycemic profile in the mothers and that the VPE decreases these parameters. In addition, FRU was genotoxic in the mothers’ peripheral tissues and VPE had a preventive effect on these parameters. The offspring showed changes in food consumption, serum FRU concentration, and body weight, in addition to an increase in the adiposity index in male offspring in the FRU (FRU) group and a decrease in the FRU + VPE group. FRU leads to hepatic steatosis in the offspring and VPE was able to decrease the area of steatosis. In addition, FRU led to genotoxicity in the offspring and VPE was able to modulate this effect, reducing damages. In conclusion, we observed that all interventions with VPE had nutritional, genetic, and biochemical benefits of the mother and her offspring.
Environmental and economic benefits of single-atom catalysts in energy conversion and storage
Authors: Velpandian Muthuraja , Sinhamahapatra Apurba , Basu Suddhasatwa 
Published: November 2023

Abstract
Single-atom catalysts have gained significant popularity in heterogeneous catalysis owing to their high activity and stability. The predominant focus of current research is centred around the dispersion of single-atom catalysts onto a support medium, aiming to enhance the efficiency of energy conversion and storage systems. The utilization of these catalysts has been associated with environmental and economic benefits. This perspective article provides an overview of the latest advancements in single-atom catalysts used for energy conversion and storage applications, with an emphasis on their potential environmental and economic benefits. It also provides insights into the future applications of single-atom catalysts in energy conversion and storage. In addition, the article investigates emerging opportunities for energy conversion and storage systems. Furthermore, the article provides a comprehensive analysis of the key benefits, challenges, and potential factors that may influence the advancement of energy conversion and storage technologies.
Does social communication make investors stay in the market?
Authors: Tong Xiaochuan , Preda Alex 
Published: November 2023

Abstract
The role of online discussions in rallying investors has been highlighted by the GameStop frenzy of 2021. We know little, however, about the effect of online discussions on investor survivorship. Previous studies have emphasized the role of communication with respect to market entry, but not with respect to market survival. Survivorship studies, in turn, have largely focused on the role of financial factors in the investors’ decision to quit trading, but have not investigated so far how social interactions and communication impact the decision to quit or stay. Using a dataset covering 1.1 million observations for 4,731 traders over 18 months, we examine the role of online discussions in traders’ decisions to stay in the market. We find that traders who actively engage in them tend to be 16 per cent to 30 per cent less likely to quit trading. We identify a positive Granger-causal relationship between online discussions and the probability of survival. Our results are robust to alternative measures of communication and different sets of control variables. Based on this evidence, we draw attention to the necessity of studying the nexus between finance and social media as an important component of platform capitalism.
Safety profile and signal detection of phosphodiesterase type 5 inhibitors for erectile dysfunction: a Food and Drug Administration Adverse Event Reporting System analysis
Authors: Shin Young Eun , Rojanasarot Sirikan , Hincapie Ana L , Guo Jeff Jianfei 
Published: November 2023

Abstract

Background
Phosphodiesterase type 5 inhibitors (PDE5Is) are generally well tolerated but have been associated with uncommon and significant adverse events (AEs).

Aim
This study aims to investigate and compare the characteristics of AEs associated with PDE5Is used for erectile dysfunction and identify any safety signals in a postmarketing surveillance database between 2010 and 2021.

Methods
A descriptive analysis was conducted for all AEs reported to the Food and Drug Administration Adverse Event Reporting System for 4 PDE5Is—avanafil, sildenafil, tadalafil, and vardenafil—indicated for erectile dysfunction between January 2010 and December 2021. The frequency of the most reported AEs and outcomes were identified. A disproportionality analysis based on proportional reporting ratio (PRR) and reporting odds ratio (ROR) was conducted for the most common and clinically important AEs to identify signals to gain insights into potential differences in safety profiles.

Outcomes
The outcome measures of the study are frequency of reported AEs and outcomes following AE.

Results
A total of 29 236 AEs were reported for PDE5Is during the study period. The most reported AE was “drug ineffective” with 7115 reports (24.3%). Eight safety signals were detected across the 4 drugs. Key signals were sexual disorders (PRR, 3.13 [95% CI, 2.69-3.65]; ROR, 3.24 [95% CI, 2.77-3.79]) and death (PRR, 3.17 [2.5-4.01]; ROR, 3.211 [2.52-4.06]) for sildenafil, priapism (PRR, 3.63 [2.11-6.24]; ROR, 3.64 [2.12-6.26]) for tadalafil, and drug administration error (PRR, 2.54 [1.84-3.52]; ROR, 2.6 [1.86-3.63]) for vardenafil. The most reported outcomes were other serious events with 6685 events (67.2%) and hospitalization with 1939 events (19.5%).

Clinical Implications
The commonly reported AEs and detected signals may guide clinicians in treatment decision making for men with erectile dysfunction.

Strengths and Limitations
This is the first comprehensive report and disproportionality analysis on all types of AEs associated with PDE5Is used for erectile dysfunction in the United States. The findings should be interpreted cautiously due to limitations in the Adverse Event Reporting System, which includes self-reports, duplicate and incomplete reports, and biases in reporting and selection. Therefore, establishing a causal relationship between the reported AEs and the use of PDE5Is is uncertain, and the data may be confounded by other medications and indications.

Conclusion
PDE5Is demonstrate significantly increased risks of reporting certain clinically important AEs. While these events are not common, it is imperative to continually monitor PDE5I use at the levels of primary care to national surveillance to ensure safe utilization.
Spain: Private client tax landscape
Authors: Carreño Florentino , San Basilio Beatriz 
Published: November 2023

Abstract
This article provides an analysis of Spain’s current private client tax landscape, explored during the 2023 Vienna Conference by The International Academy of Estate and Trust Law. It offers insights into personal income, wealth, inheritance and gift taxation, as well as aspects of Spanish residence and citizenship. With a strong focus on family and estate planning, it sheds light on the tax opportunities presented by relocating to Spain.
Prognostic Factors of Perceived Disability and Perceived Recovery After Whiplash
Authors: Pedrero-Martin Yolanda , Falla Deborah , Rodriguez-Brazzarola Pablo , Torrontegui-Duarte Marcelino , Fernandez-Sanchez Manuel , Jerez-Aragones Jose Manuel , Bernard Liew , Luque-Suarez Alejandro 
Published: November 2023

Objectives.
The understanding of the role that cognitive and emotional factors play in how an individual recovers from a whiplash injury, is important. Hence, we sought to evaluate if pain-related cognitions (self-efficacy beliefs, expectation of recovery, pain catastrophizing, optimism, and pessimism) and emotions (kinesiophobia) are longitudinally associated with the transition to chronic whiplash associated disorders (WAD) in terms of perceived disability, and perceived recovery at 6 and 12-months.

Methods:
One-hundred and sixty-one participants with acute or subacute WAD were included. The predictors were: self-efficacy beliefs, expectation of recovery, pain catastrophizing, optimism, and pessimism, pain intensity, and kinesiophobia. The two outcomes were the dichotomized scores of perceived disability and recovery expectations at six and twelve months. Stepwise regression with bootstrap resampling was performed to identify the predictors most strongly associated with the outcomes, and the stability of such selection.

Results.
Baseline perceived disability, pain catastrophizing, and expectation of recovery were the most likely to be statistically significant, with an overage frequency of 87.2%, 84.0%, and 84.0%, respectively.

Discussion:
Individuals with higher expectation of recovery and lower levels of pain catastrophizing and perceived disability at baseline, have higher perceived recovery and perceived disability at 6 and 12-months. These results have important clinical implications as both factors are modifiable via health education approaches.
Spinal Cord Signal Intensity Predicts Functional Outcomes in the Operative Management of Degenerative Cervical Myelopathy
Authors: Firempong Gaylinn Kwame , Sheppard William L. , Gelfand Yaroslav , Ellingson Benjamin M. , Holly Langston T. 
Published: November 2023

Study Design:
Prospective single institutional cohort study on degenerative cervical myelopathy (DCM) from 2009 to 2022.

Objective:
This study aims to assess the relationship among preoperative spinal cord signal change, postoperative signal change evolution, and functional outcome in patients undergoing surgery for DCM.

Summary of Background Data:
There is conflicting evidence on whether spinal cord signal intensity influences functional outcomes in patients with DCM.

Patients and Methods:
This prospective study investigated 104 patients with DCM that underwent both preoperative and routine postoperative cervical spine magnetic resonance imaging (MRI) as part of a research protocol. Signal intensity/grade, modified Japanese Orthopedic Association (mJOA) scores, signal resolution, and patient demographics were assessed.

Results:
Sixty-eight of the subjects were found to have abnormal T2 spinal cord signal intensity changes on their preoperative MRI. The total mean preoperative mJOA score was 13.6, increasing postoperatively to 16 (P < 0.001). The presence or absence of preoperative spinal cord signal change was not associated with the change in mJOA score or neurological recovery rate after surgery. Of the 68 patients with preoperative T2 signal change, 36 were found to have an improvement in the T2-weighted signal grade after surgery and 32 had no change in postoperative signal grade. The mean improvement in mJOA score (3.7) and neurological recovery rate (70.3%) was significantly higher in the patients with preoperative signal change whose postoperative MRI signal change grade improved by at least one point compared with those that did not (2.0, 50.5%), (P < 0.001, P < 0.003).

Conclusions:
The presence of preoperative T2-weighted signal change was associated with lower preoperative mJOA scores, but no change in mJOA after surgery or postoperative neurological recovery rate. However, improvement in T2-weighted spinal cord signal grade on postoperative MRI was significantly associated with a degree of neurological improvement after surgery.