bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient Green Spin Light-Emitting Diodes Enabled by Ultrafast Energy- and Spin-Funneling in Chiral Perovskites
Authors: Lu Haipeng , Yao Jingwen , Wang Zhiyu , Huang Yuling , Xue Jie , Zhang Dengliang , Chen Jiangshan , Chen Xihan , Dong Shou-Cheng 
Published: November 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Soil degradation and herbicide pollution by repeated cassava monoculture within Thailand’s conservation region
Authors: Popradit Ananya , Nakhokwik Yutthana , Robischon Marcel , Saiki Shin-Taro , Yoshimura Jin , Wanasiri Arichai , Ishida Atsushi 
Published: November 2023

Abstract
In a national park in Northeast Thailand, agricultural land has been converted from natural forest by small-scale farmers. To investigate the impact of repeated cassava monoculture on soil, we conducted a five-year (2016–2020) study on the physical and chemical properties of soil in cassava farmland and examined the properties of forest soil as a control. Soil nitrogen, available phosphate and potassium, and bulk density were significantly higher in the farmland than in the forest, whereas organic matter and cation exchange capacity were the opposite. In the farmland, soil nitrogen, electrical conductivity, and bulk density increased significantly, whereas pH and organic matter decreased significantly, indicating that soil degradation progressed during the five years. The use of glyphosate and paraquat herbicides is prohibited within national parks. However, in 2020, glyphosate was detected in farmland soil at levels of up to 5.0 mg kg-1 during both the rainy and dry seasons, and glyphosate (2.5 mg l-1) was detected in stream water from the farmland during the dry season. The use of glyphosate in the farmland was suspected at least in 2020. Soil degradation and herbicide pollution may carry a high risk of causing irreversible changes to the terrestrial ecosystems.
Elucidating the Role of let-7d-5p and OLR1 in Progression and Prognosis of Oral Squamous Cell Carcinoma via FAK/P53 Signaling axis
Authors: Lin Che-Hsuan , Chiang Chih-chiu , Shih Ya-Chi , Tung Shiao-Lin , Huang Wei-Chieh 
Published: November 2023

Abstract
Purpose: This study investigates the role of let-7d-5p microRNA (miRNA) and its target gene OLR1 in oral squamous cell carcinoma (OSCC), focusing on their implications in tumor progression, metastasis and potential as therapeutic targets. Despite advances in OSCC diagnosis and treatment, the five-year survival rate remains low, underscoring the need for improved biomarkers and therapeutic strategies. We aim to elucidate the regulatory functions of let-7d-5p and OLR1 in OSCC pathogenesis.
Methods: Employing next-generation sequencing and bioinformatic tools, we profiled differentially expressed miRNAs in metastatic OSCC cell lines, identifying let-7d-5p as a key downregulated miRNA and OLR1 as a novel target of let-7d-5p. We validated this interaction using luciferase reporter assays and studied the biological effects of modulating let-7d-5p and OLR1 expression on OSCC cell proliferation, migration, invasion and stemness. Additionally, we analyzed clinical data to establish the relevance of OLR1 expression in OSCC prognosis.
Results: Our findings reveal let-7d-5p as a potent suppressor of OSCC metastasis, primarily by targeting and downregulating OLR1. OLR1-silencing reduced OSCC cell invasiveness, migration, and stemness, implicating its prominent role in tumor progression. Mechanistically, let-7d-5p modulates a signaling cascade involving FAK, SRC, PAXILLIN, and P53, influencing cellular apoptosis and chemoresistance. Clinically, elevated OLR1 expression significantly correlates with advanced OSCC stages and poorer survival rates, highlighting its potential as a prognostic marker and therapeutic target.
Conclusion: Our study uncovers the significance of the let-7d-5p-OLR1 axis in OSCC pathogenesis, offering novel insights for future therapeutic interventions.
Psychomotor Vigilance Task indices are correlated with and can predict the Major Depressive Disorder
Authors: Fan Xiwang , Zhong Yiwen , Li Zheyin , Zheng Yi , Wang Xuesong , He Jibo , Zhao Xudong , Chen Fazhan 
Published: November 2023

Abstract
Background:
Accurate assessment of major depressive disorder (MDD) has been a common topic with regard to assessment tools and psychopathology. Currently, popular tools such as the Self-rating Depression Scale (SDS) and other self-report assessments are insufficient, as patients might be incapable of recalling or evaluating themselves. The psychomotor vigilance task (PVT), which can be used for the evaluation of MDD, does not require patients to evaluate themselves, and thus might be a good assessment tool.
Method:
We selected 93 patients diagnosed with MDD to participate in this study. Each of them was evaluated using the Hamilton Depression Rating Scale (HAMD) scores and PVT indices. One-way analysis of variance ( ) of the depression level and five PVT indices was conducted to examine the association. Linear regression analysis was then conducted between the HAMD scores and PVT indices.
Result:
We found that certain PVT indices showed a statistically significant relationship with the HAMD and other factor scores. On linear regression analyses, the optimum reaction time (RT) median ( = 0.007) showed a positive relationship with the HAMD scores, whereas the median RT reciprocal ( = 0.039) showed a negative relationship with HAMD. Simultaneously, these two indices showed a significant relationship with some other factor scores.
Conclusion:
The results of this study demonstrate the usefulness of PVT indices in predicting depression severity. This evidence suggests that PVT could serve as a potential screening tool because it is quick, non-intrusive, and universally adaptable in different clinical scenarios.
A Digital speckle stereo matching algorithm based on epipolar line correction
Authors: Liu Liping , Niu Boya , Xu Zhuo , Zhang Songyang , Shao Zhaoyu , Wang Xinyu 
Published: November 2023

Abstract
When the digital speckle correlation method takes images in some working conditions, the left and right images appear weak correlation due to the extreme inclination of the camera, which leads to the difficulty of matching. In order to solve the above problem, a digital speckle stereo matching algorithm based on epipolar correction is proposed in this paper, and an estimation method of deformational iterative initial values of the first-order shape function in the stereo matching process is given through theoretical derivation. The Newton-Raphson (NR) method can be directly used for fine matching in the original left and right images through the estimated deformational iterative initial value. The digital speckle matching experiment under different camera inclination angles of 24.2°, 34.2°, 41.15°, 47.3° and 52.4° is carried out to verify the effectiveness of the digital speckle stereo matching algorithm based on epipolar correction. The experimental results show that this method can complete the matching well under different inclined field of view, and the matching success rate is close to 100%, which can at least meet the requirement of digital speckle matching and deformation strain measurement under the inclination angle less than 52.4° field of view.
Colorectal adenoma is positively associated with insulin resistance and polyp’s VCAM-1 expression in humans
Authors: Wang Hao , Wang Haipeng , Jin Yuqin , Wang Dongyang , Chen Ming , Zhang Hao , Dong Guangfeng , Li Zengjun 
Published: November 2023

Abstract
BACKGROUND
Accumulating evidence suggests that insulin resistance (IR) is closely linked to colorectal cancer (CRC). Some studies have revealed that IR may be associated with metabolites in colonocytes and may play a proto-oncogenic role.
OBJECTIVE
This study aims to investigate the relationship between colorectal adenoma and insulin resistance and its associated VCAM-1.
METHOD
49 patients diagnosed with intestinal polyps between June 2019 and September 2021 at the Shandong Cancer Hospital were recruited in this study. Fasting insulin (Fins), fasting blood glucose (FBG), HOMA-IR, and polyp’s VCAM-1 mRNA levels were determined in these patients. Univariate and multivariate logistic regression analysis to identify independent predictors of the aggressive clinical behavior of polyps.
RESULTS
Patients with adenomatous polyps had significant higher levels of fasting insulin (Fins), fasting blood glucose (FBG), HOMA-IR, and polyp’s VCAM-1 mRNA than those with inflammatory polyps. Multivariate binary logistic regression analysis indicated that HOMA-IR was an independent predictive factor for adenomatous polyps. Cross-tabulation and Pearson’s chi-square tests identified that adenomatous polyps had higher levels of VCAM-1 than inflammatory polyps.
CONCLUSION
Colorectal adenoma is positively associated with insulin resistance and polyp’s VCAM-1 expression, suggesting an important role of insulin resistance in the formation and progression of intestinal tumor.
Fibroblast Growth factor 23 for prediction of outcome in community- acquired acute kidney injury: a prospective observational study
Authors: Elkot Mahmoud Naguib , Nassar Mohammed Kamal , Sayed-Ahmed Nagy , Atwa Mohamed Ali , Eldeeb Ahmed 
Published: November 2023

Abstract

Background
Serum Fibroblast Growth factor 23 (FGF23) level has been found to be elevated in AKI through multiple previous studies. Moreover, higher FGF23 level was associated with mortality and adverse outcomes in critically ill patients and patients undergoing cardiac surgery who developed acute kidney injury (AKI) suggesting that FGF23 can have a prognostic value in AKI. The current study aims to investigate the association of serum FGF23 levels with morbidity and mortality in patients with community-acquired AKI.
Methods
A longitudinal prospective study was carried out that included 64 patients who presented with community-acquired AKI to Mansoura Nephrology and Dialysis Unit (MNDU) at Mansoura University Hospital. Serum intact FGF23 level was measured after admission. patients were followed up during hospital stay and then at 90-day after admission. The primary outcomes were hospital and 90-day mortality and renal recovery.
Results
In this study, nine of the studied 64 AKI patients (14.1%) died during hospital admission and 18 out of 62 AKI patients (29%) died during the 90-day follow up period including those who died during hospital admission. Hospital mortality was significantly higher in patients with shock, sepsis, hypoalbuminemia, or high FGF23 in univariate analysis (p < 0.05). However, when binary logistic regression was carried out, shock was the only significant independent predictor for mortality [p value = 0.015; adjusted odds ratio = 12.465], while serum FGF23 did not independently predict in-hospital [p value = 0.589; adjusted odds ratio = 1.001] or 90-day mortality [p value = 0.055; adjusted odds ratio = 1.003] when entered in the regression equation together with the other confounders. Serum FGF23 in this study was not also associated with renal recovery, need for renal replacement, or the duration from peak serum creatinine to renal recovery (p > 0.05).
Conclusion
This research showed that serum iFGF23 could not predict mortality, renal recovery, or need for renal replacement therapy in patients with community-acquired AKI.
EchoSense: A framework for Analyzing the Echo Chambers phenomenon: A Case Study on Qatar Events
Authors: Kavargyris Dimitrios Christos , Georgiou Konstantinos , Angelis Lefteris 
Published: November 2023

Abstract

The impact of social media on information exchange is profound, providing valuable access to public information, but it can also intensify negative effects like cognitive bias, opinion extremism, and misinformation through the creation of echo chambers. These echo chambers, characterized by repeated information within closed systems, result from preferential exposure, homophily, and social impact. In this study, we present EchoSense, a framework that can conduct a comprehensive analysis of echo chambers on specific topics using both content and social network analysis and develop effective strategies to address the impact of echo chambers on public discourse and democratic processes. The objective of our developed framework is to serve as a comprehensive guide for detecting echo chambers, with a particular focus on the issue of racial discrimination and worker conditions in the Qatar World cup of 2022, For this purpose, over one million tweets were collected and stored, spanning from January 2022 to the beginning of the World Cup in Qatar. Through this comprehensive analysis, we aspire to contribute to a better understanding of echo chambers while addressing polarization concerns within online communities.
Democratising Complex System Modelling
Authors: Pardi Anabele-Linda , Burina Elizaveta 
Published: November 2023

Abstract

In the contemporary context of an acute need for sustainability and swift response to imminent crises such as global warming, pandemics and economic system disruptions, the focus on responsible decision making, ethical risk assessment and mitigation at all organizational levels is an overarching goal. Our aim is to introduce a deterministic method for investigating the stability of complex systems, in order to find the most important elements of such systems and their impact on different scenarios. The novelty of the current approach lies in its compact format and intuitive nature, designed to accommodate a limited amount of computational resources. The proposed modelling method involves the mapping of complex systems from a diversity of disciplines (economic markets and the resource management domain) onto a sequence of chemical reactions and involving a subsequent mathematical analysis. Mapping the results back onto the use cases shows that one can retrieve a considerable amount of detail, making the modeling strategy general enough to be adaptable and scalable while also detailed enough to provide valuable insights for practical scenarios.
Teoria crítica da sociedade em Jürgen Habermas
Authors: Siqueira Daniel Valente Pedroso de 
Published: November 2023

O presente texto observa a teoria crítica da sociedade desenvolvida por Habermas a partir da análise das duas teses apresentadas na Teoria da Ação Comunicativa, sobre a modernidade seletiva e sobre o desacoplamento das esferas socais tematizáveis, pretendendo compreender como o avanço dos imperativos funcionais do sistema (a burocracia administrativa estatal e a economia capitalista) têm extrapolado suas áreas de atuação e aumentado ainda mais sua dinâmica sistêmica sobre o ambito da reprodução simbólica nas sociedades capitalistas do século XXI. A discussão que se segue analisará esta ampliação considerando que as interferências e alterações sobre os padrões de integração social são questões que se encontram em um desenvolvimento constante desde as mudanças pelas quais passaram a alterar os critérios de legitimação da modernidade capitalista. Ainda que de um modo não inteiramente distinto daquele tematizado por Habermas no contexto social do início dos anos 1980, pretende-se observar que que no atual estágio do capitalismo internacional esta interferência, assim como as alterações daí promovidas, tem provocado uma maior fragmentação social e gerado bloqueios que perturbam ainda mais a integração social (que ameaçam inviabilizar qualquer efetivação da emancipação social quanto mais são deturpados os critérios de legitimação e reconhecimento social). Circunscrito a este horizonte, pretende-se sustentar que tais fatores possam ser melhor compreendidos mediante uma investigação sobre as patologias sociais, especifiamente quando estas são compreendidas como parâmetros que proporcionariam identificar certa resistência a uma integração social orientada por imperativos sistêmicos.
Recent Insights into the Angioregulatory Role of Long Non-coding
RNAs and Circular RNAs in Gliomas: From Signaling Pathways to
Clinical Aspects
Authors: Hedayati Neda , Babaei Aghdam Zahra , Rezaee Malihe , Mousavi Dehmordi Rohollah , Alimohammadi Mina , Mafi Alireza 
Published: November 2023

Abstract:
The most prevalent and severe malignancy of the central nervous system
within the brain is glioma. Glioma is a vascularized cancer, and angiogenesis is necessary
for glioma growth, invasion, and recurrence. It is also believed that this factor is
this factor to be accountable for therapy resistance in many cancers, including glioma.
The process of angiogenesis, which plays a crucial role in both health and disease situations
such as cancer, involves the creation of new blood vessels from pre-existing ones.
Non-coding RNAs (ncRNAs) are unique molecules that have been found to possess a
wide range of abilities to modify the expression of various genes. They carry out their
gene-modulating roles at a variety of distinct levels, including post-transcriptional and
post-translational levels. Long ncRNAs (lncRNAs) and circular RNAs (circRNAs) are a
group of ncRNA that have attracted particular attention and are involved in the angiogenesis
mechanism in cancer. Understanding the regulatory mechanisms of these RNAs in
the angiogenesis process in gliomas provides unique fundamental information about the
process of tumor-associated neovascularization. On the other hand, due to developments
in the characterisation of lncRNAs and circRNAs, these novel structures may potentially
be used in clinics as possible biomarkers for treatment strategies that target tumor angiogenesis.
Throughout the review, new knowledge and views about the angioregulatory
function of circRNAs and lncRNAs in gliomas have been presented. Additionally, we
talk about the novel idea of ncRNA-based therapeutics for gliomas in the future.
Poly(lactic-co-glycolic) Acid (PLGA) Nanoparticles and Transdermal Drug Delivery:
An Overview
Authors: Kumar Lalit , Kukreti Gauree , Rana Ritesh , Chaurasia Himanshu , Sharma Anchal , Sharma Neelam , Komal  
Published: November 2023

Background:
Biodegradable polymeric nanoparticles have garnered pharmaceutical industry attention
throughout the past decade. PLGA [Poly(lactic-co-glycolic acid)] is an excellent biodegradable polymer
explored for the preparation of nanoparticles that are administered through various routes like intravenous and
transdermal. PLGA's versatility makes it a good choice for the preparation of nanoparticles.

Objective:
The main objective of this review paper was to summarize methods of preparation and characterization
of PLGA nanoparticles along with their role in the transdermal delivery of various therapeutic agents.

Methods:
A literature survey for the present review paper was done using various search engines like Pubmed,
Google Scholar, and Science Direct.

Results:
In comparison to traditional transdermal administration systems, PLGA nanoparticles have demonstrated
several benefits in preclinical investigations, including fewer side effects, low dosage frequency, high
skin permeability, and simplicity of application.

Conclusion:
PLGA nanoparticles can be considered efficient nanocarriers for the transdermal delivery of
drugs. Nevertheless, the clinical investigation of PLGA nanoparticles for the transdermal administration of
therapeutic agents remains a formidable obstacle.
FTIR, 1H, and 13C NMR Characterization and Antibacterial Activity of
the Combination of Euphorbia Honey and Potato Starch
Authors: Ahmed Moussa , Amirat Mokhtar 
Published: November 2023

Aim and Objective:
In recent years, natural biopolymer (potato starch) hydrogels
have been widely used in the field of wound dressing material. This study aimed to develop and
characterize a novel antibacterial hydrogel made from potato starch and natural honey.

Methods:
The structure of the composite films was evaluated by Fourier transform infrared
(FTIR) and 1H,13C nuclear magnetic resonance (NMR) spectroscopy, and the antibacterial activities
were tested by agar diffusion method. FTIR analysis showed chemical interaction between
the components of Euphorbia honey (EH) and potato starch hydrogel (PSH).

Results:
The 1H–13C NMR and FTIR analyses of EH/PSH confirmed their structure and showed
the presence of glucose and hydrocarbon derivatives. After 24 h of incubation, the EH/PSH hydrogel
showed good antibacterial activity against three bacterial strains (K.pneumonia,
P.mirabilis, and P. aeruginosa) by producing clear inhibition zones of 12.33±1.88 mm,
15.33±0.94, and 10±0 mm, respectively. In addition, K. pneumonia, P. mirabilis, and P. aeruginosa
were sensitive to the EH/SPH with a minimum inhibitory concentration (MIC) of 1 %.

Conclusion:
These results suggest that EH–PS has potential as an alternative candidate to conventional
antibiotics.
Potential of Flavonoids as Promising Phytotherapeutic Agents to Combat
Multidrug-Resistant Infections
Authors: Pathak Deepika , Mazumder Avijit 
Published: November 2023

Background:
Considering the limited number of current effective treatments, Multidrug-
Resistant (MDR) illnesses have grown to be a serious concern to public health. It has become
necessary to look for new antimicrobial drugs because of the emergence of resistance to
numerous kinds of antibiotics. The use of flavonoids is one phytotherapeutic strategy that has
been researched as a potential remedy for this issue. Secondary plant compounds called flavonoids
have been found to have an antibacterial effect against resistant microorganisms.

Objective:
This review seeks to give readers a glimpse into contemporary studies on flavonoids'
potential to fight MDR infections.

Methods:
A systematic search was conducted on electronic databases (PubMed, Scopus, and
Google Scholar) using relevant keywords such as flavonoids, MDR infections, antimicrobial
activity, and resistance microbes. Studies that investigated the antimicrobial activity of flavonoids
against resistant microbes were included in this review.

Results:
Most research found that flavonoids have antibacterial efficacy against resistant microorganisms,
and some also showed that they have synergistic benefits with traditional antibiotics.
The flavonoids quercetin, kaempferol, apigenin, and luteolin were the most often investigated
ones. According to research, flavonoids affect microbial gene expression, inhibit microbial enzymes,
and disrupt the integrity of microbial cell membranes. Additionally, a few studies have
noted the flavonoids' low toxicity and safety.

Conclusion:
For the treatment of infections that are resistant to many drugs, flavonoids constitute
a promising class of phytotherapeutic agents. To develop flavonoid-based treatment methods
for treating MDR illnesses and assess the potential of flavonoids as adjuvants to conventional
antimicrobial drugs, more study is required.
Hypoxia A Typical Target in Human Lung Cancer Therapy
Authors: Ullah Asmat , Shehzadi Somia , Ullah Najeeb , Nawaz Touseef , Iqbal Haroon , Aziz Tariq 
Published: November 2023

Abstract:
Lung cancer (LC) is the leading cause of cancer-related death globally. Comprehensive
knowledge of the cellular and molecular etiology of LC is perilous for the development of active
treatment approaches. Hypoxia in cancer is linked with malignancy, and its phenotype is implicated
in the hypoxic reaction, which is being studied as a prospective cancer treatment target. The hypervascularization
of the tumor is the main feature of human LC, and hypoxia is a major stimulator
of neo-angiogenesis. It was seen that low oxygen levels in human LC are a critical aspect of
this lethal illness. However, as there is a considerable body of literature espousing the presumed
functional relevance of hypoxia in LC, the direct measurement of oxygen concentration in Human
LC is yet to be determined. This narrative review aims to show the importance and as a future target
for novel research studies that can lead to the perception of LC therapy in hypoxic malignancies.