bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verantwortung für die Arbeit tragen
Authors: Kalisnik Felix 
Published: November 2023

Was ist zu diesem Thema bereits bekannt? Berufseinsteiger_innen sind sich dem beruflichen Rollenwechsel hin zur Verantwortung bewusst. Dafür wird vor allem Zeit benötigt, damit das berufliche Selbstbewusstsein gestärkt wird. Wie wird eine neue Perspektive eingebracht? Insbesondere Gewalt, Aggression und Zwangsmaßnahmen stellen für Berufseinsteiger_innen eine Herausforderung im psychiatrischen Pflegesetting dar. Zwangsmaßnahmen werden kritisch betrachtet. Was sind die Auswirkungen für die Praxis? Berufseinsteiger_innen benötigen erfahrenes Personal, das Sicherheit und Wissen vermittelt.
Die Lücke schließen
Authors: Sonderegger Stefanie , Schlüer Anna-Barbara 
Published: November 2023

Was ist zu diesem Thema bereits bekannt? Jugendliche mit Anorexia nervosa (AN) haben ein hohes Risiko für einen chronischen Krankheitsverlauf mit wiederkehrenden Hospitalisationen. Wie wird eine neue Perspektive eingebracht? Die Advanced-Practice-Nurse (APN) begleitet Jugendliche und deren Eltern über die Hospitalisation hinaus. Sie ist als bekannte Vertrauensperson niederschwellig erreichbar und kann so kurzfristig in Krisen Hilfestellung bieten. Was sind die Auswirkungen für die Praxis? Die kontinuierliche Begleitung im Übergang von stationär ins häusliche Umfeld sollte gezielt sichergestellt werden.
Reviving the Aral Sea: A Hydro‐Eco‐Social Perspective
Authors: Wang Xiaolei , Zhang Junze , Wang Shuai , Ge Yongxiao , Duan Zihao , Sun Lin , Meadows Michael E. , Luo Yi , Fu Bojie , Chen Xi , Huang Yue , Ma Xiaoting , Abuduwaili Jilili 
Published: November 2023

AbstractThe rapid shrinkage and salinization of the Aral Sea over the last few decades has precipitated an environmental disaster, with widespread implications for people whose livelihoods depend on it. Although debated extensively, few viable strategies have yet been identified for reviving the Aral Sea. Here, we propose a hydro‐eco‐social framework to develop a viable, sustainable solution and explore its feasibility to resolve the Aral Sea problem. Based on eco‐environmental indicators, we contend that it is feasible to raise the Aral Sea by 40 m above the Baltic Sea level, while maintaining salinity levels tolerable for aquatic organisms, simultaneously reducing sandstorm risk by 58%. Basin‐wide water balance under climate change scenarios shows that this level can be supported through management interventions that reduce water usage by 22.0–23.2 km3/year and ensure sufficient recharge into the lake, without compromising socio‐economic opportunities. To implement this solution, we propose establishing a socio‐ecologically aligned water governance network for basin‐scale water management that has potential application for other, similarly declining, major lake systems.
The Geophysical Properties of FeHx Phases Under Inner Core Conditions
Authors: Yang Hua , Dou Peixue , Xiao Tingting , Li Yunguo , Muir Joshua M. R. , Zhang Feiwu 
Published: November 2023

AbstractHydrogen has been proposed as an important light element in planetary iron cores, while the crystal structure and thermoelasticity of FeHx (x = 1) (FeH hereafter) under inner core conditions remain largely unknown. Recent studies report that FeH adopts an face‐centered cubic (fcc) structure up to core conditions. In this study, using ab initio molecular dynamics, we calculate the free energy and elastic properties of FeH at high P‐T conditions. Our results indicate that the hexagonal close‐packed (hcp) structure of FeHx is favored by both the low hydrogen concentration and the elevated temperature of inner‐core conditions. We also clarify that lattice hydrogen hardens the wave velocities of iron while superionic hydrogen softens it. Both fcc‐ and hcp‐FeH can match inner‐core wave velocities and Poisson's ratio, which supports the hypothesis of hydrogen as a vital light element in the Earth's core.
Imaging the Plumbing System of the Asymmetric Vavilov Spreading Ridge (Tyrrhenian Sea Back‐Arc Basin) From Combined Bathymetry and Magnetic Data
Authors: Cocchi L. , Muccini F. , Palmiotto C. , Ventura G. 
Published: November 2023

AbstractBack‐arc basins (BABs) are associated with plate margins where crustal shortening, seafloor spreading, and volcanism coexist. The Vavilov basin (Tyrrhenian Sea) is a Pliocene BAB associated with the Apennine‐Tyrrhenian Sea subduction system and characterized by mantle exhumation. The NNE‐SSW elongated Vavilov seamount represents the easternmost and younger spreading ridge of the Vavilov basin. Here we present results of a morphological and magnetic study of the Vavilov seamount. Our results show that the seamount represents the last stage of the eastward asymmetric opening of the BAB. Its plumbing system consists of a dike swarm emplaced during the reversed Matuyama epoch and a younger shallow reservoir feeding the central and eastern sectors during the normal Brunhes epoch. This evolution is associated with the progressive loading of the edifice due to lava flow emplacement. The asymmetry of the seamount mirrors the asymmetric opening of the Vavilov back‐arc basin.
Unique Collections of 14C‐Dated Vegetation Reveal Mid‐Holocene Fluctuations of the Quelccaya Ice Cap, Peru
Authors: Lamantia Kara , Thompson Lonnie , Davis Mary , Mosley‐Thompson Ellen , Stahl Henry 
Published: November 2023

AbstractSeveral studies have analyzed the ice margin behavior of the Quelccaya Ice Cap (QIC), Earth's largest tropical ice cap, through the Holocene. However, continuous integration of new information to produce a more cohesive history of the QIC is necessary. Here, the radiocarbon dates of 33 rooted plant specimens collected in situ along the western ice margin between 2002 and 2018 reveal the timing of its past extent as it advanced during the mid‐Holocene. The most recent evaluation of collected specimens indicates that the QIC margin advanced ∼350 m down the Challpacocha Valley between 7.1 and 4.5 ka BP. Past studies of documented ice extent on the western side of the QIC based on a variety of techniques are compiled to create a more comprehensive history of the QIC's behavior throughout the Holocene. Records of documented ice extent, as well as other proxy records, indicate a climate transition ∼5–7 ka BP that created the proper environmental conditions for the expansion of the QIC. Evidence from nearby valleys indicates that the QIC behaved similarly to the documented ice extent in the Challpacocha Valley in response to Holocene climatic fluctuations. The ability to collect the plant specimens and recent analysis of satellite imagery reveals rapid retreat rates of the western outlet glaciers from 1985 to 2020, leaving the western margin of the QIC at its smallest extent since the mid‐Holocene.
Multifunctional mesoporous silica nanoparticles for biomedical applications
Authors: Xu Bolong , Li Shanshan , Shi Rui , Liu Huiyu 
Published: November 2023

AbstractMesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, and excellent biocompatibility. Over the past two decades, researchers have developed a wide variety of MSNs-based nanoplatforms through careful design and controlled preparation techniques, demonstrating their adaptability to various biomedical application scenarios. With the continuous breakthroughs of MSNs in the fields of biosensing, disease diagnosis and treatment, tissue engineering, etc., MSNs are gradually moving from basic research to clinical trials. In this review, we provide a detailed summary of MSNs in the biomedical field, beginning with a comprehensive overview of their development history. We then discuss the types of MSNs-based nanostructured architectures, as well as the classification of MSNs-based nanocomposites according to the elements existed in various inorganic functional components. Subsequently, we summarize the primary purposes of surface-functionalized modifications of MSNs. In the following, we discuss the biomedical applications of MSNs, and highlight the MSNs-based targeted therapeutic modalities currently developed. Given the importance of clinical translation, we also summarize the progress of MSNs in clinical trials. Finally, we take a perspective on the future direction and remaining challenges of MSNs in the biomedical field.
microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance
Authors: Fattahi Mehdi , Rezaee Delsuz , Fakhari Fatemeh , Najafi Sajad , Aghaei-Zarch Seyed Mohsen , Beyranvand Parisa , Rashidi Mohammad Amin , Bagheri-Mohammadi Saeid , Zamani-Rarani Fahimeh , Bakhtiari Mohammad , Bakhtiari Abbas , Falahi Shahab , Kenarkoohi Azra , Majidpoor Jamal , Nguyen P. U. 
Published: November 2023

AbstractMicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with a short length of 19–22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in various biological processes like cell growth, apoptosis, and angiogenesis. miR-184 is a well-studied miRNA, for which most studies report its downregulation in cancer cells and tissues and experiments support its role as a tumor suppressor inhibiting malignant biological behaviors of cancer cells in vitro and in vivo. To exert its functions, miR-184 affects some signaling pathways involved in tumorigenesis like Wnt and β-catenin, and AKT/mTORC1 pathway, oncogenic factors (e.g., c-Myc) or apoptotic proteins, such as Bcl-2. Interestingly, clinical investigations have shown miR-184 with good performance as a prognostic/diagnostic biomarker for various cancers. Additionally, exogenous miR-184 in cell and xenograft animal studies suggest it as a therapeutic anticancer target. In this review, we outline the studies that evaluated the roles of miR-184 in tumorigenesis as well as its clinical significance.
Mode attraction, rejection and control in nonlinear multimode optics
Authors: Ji Kunhao , Davidson Ian , Sahu Jayanta , Richardson David J. , Wabnitz Stefan , Guasoni Massimiliano 
Published: November 2023

AbstractNovel fundamental notions helping in the interpretation of the complex dynamics of nonlinear systems are essential to our understanding and ability to exploit them. In this work we predict and demonstrate experimentally a fundamental property of Kerr-nonlinear media, which we name mode rejection and takes place when two intense counter-propagating beams interact in a multimode waveguide. In stark contrast to mode attraction phenomena, mode rejection leads to the selective suppression of a spatial mode in the forward beam, which is controlled via the counter-propagating backward beam. Starting from this observation we generalise the ideas of attraction and rejection in nonlinear multimode systems of arbitrary dimension, which paves the way towards a more general idea of all-optical mode control. These ideas represent universal tools to explore novel dynamics and applications in a variety of optical and non-optical nonlinear systems. Coherent beam combination in polarisation-maintaining multicore fibres is demonstrated as example.
Functional diversity of sharks and rays is highly vulnerable and supported by unique species and locations worldwide
Authors: Pimiento Catalina , Albouy Camille , Silvestro Daniele , Mouton Théophile L. , Velez Laure , Mouillot David , Judah Aaron B. , Griffin John N. , Leprieur Fabien 
Published: November 2023

AbstractElasmobranchs (sharks, rays and skates) are among the most threatened marine vertebrates, yet their global functional diversity remains largely unknown. Here, we use a trait dataset of >1000 species to assess elasmobranch functional diversity and compare it against other previously studied biodiversity facets (taxonomic and phylogenetic), to identify species- and spatial- conservation priorities. We show that threatened species encompass the full extent of functional space and disproportionately include functionally distinct species. Applying the conservation metric FUSE (Functionally Unique, Specialised, and Endangered) reveals that most top-ranking species differ from the top Evolutionarily Distinct and Globally Endangered (EDGE) list. Spatial analyses further show that elasmobranch functional richness is concentrated along continental shelves and around oceanic islands, with 18 distinguishable hotspots. These hotspots only marginally overlap with those of other biodiversity facets, reflecting a distinct spatial fingerprint of functional diversity. Elasmobranch biodiversity facets converge with fishing pressure along the coast of China, which emerges as a critical frontier in conservation. Meanwhile, several components of elasmobranch functional diversity fall in high seas and/or outside the global network of marine protected areas. Overall, our results highlight acute vulnerability of the world’s elasmobranchs’ functional diversity and reveal global priorities for elasmobranch functional biodiversity previously overlooked.
Reputations for treatment of outgroup members can prevent the emergence of political segregation in cooperative networks
Authors: Simpson Brent , Montgomery Bradley , Melamed David 
Published: November 2023

AbstractReputation systems promote cooperation and tie formation in social networks. But how reputations affect cooperation and the evolution of networks is less clear when societies are characterized by fundamental, identity-based, social divisions like those centered on politics in the contemporary U.S. Using a large web-based experiment with participants (N = 1073) embedded in networks where each tie represents the opportunity to play a dyadic iterated prisoners’ dilemma, we investigate how cooperation and network segregation varies with whether and how reputation systems track behavior toward members of the opposing political party (outgroup members). As predicted, when participants know others’ political affiliation, early cooperation patterns show ingroup favoritism. As a result, networks become segregated based on politics. However, such ingroup favoritism and network-level political segregation is reduced in conditions in which participants know how others behave towards participants from both their own party and participants from the other party. These findings have implications for our understanding of reputation systems in polarized contexts.
Dynamical control enables the formation of demixed biomolecular condensates
Authors: Lin Andrew Z. , Ruff Kiersten M. , Dar Furqan , Jalihal Ameya , King Matthew R. , Lalmansingh Jared M. , Posey Ammon E. , Erkamp Nadia A. , Seim Ian , Gladfelter Amy S. , Pappu Rohit V. 
Published: November 2023

AbstractCellular matter can be organized into compositionally distinct biomolecular condensates. For example, inAshbya gossypii, the RNA-binding protein Whi3 forms distinct condensates with different RNA molecules. Using criteria derived from a physical framework for explaining how compositionally distinct condensates can form spontaneously via thermodynamic considerations, we find that condensates in vitro form mainly via heterotypic interactions in binary mixtures of Whi3 and RNA. However, within these condensates, RNA molecules become dynamically arrested. As a result, in ternary systems, simultaneous additions of Whi3 and pairs of distinct RNA molecules lead to well-mixed condensates, whereas delayed addition of an RNA component results in compositional distinctness. Therefore, compositional identities of condensates can be achieved via dynamical control, being driven, at least partially, by the dynamical arrest of RNA molecules. Finally, we show that synchronizing the production of different RNAs leads to more well-mixed, as opposed to compositionally distinct condensates in vivo.
Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening
Authors: Parijat Priyanka , Attili Seetharamaiah , Hoare Zoe , Shattock Michael , Kenyon Victor , Kampourakis Thomas 
Published: November 2023

AbstractDirect modulation of cardiac myosin function has emerged as a therapeutic target for both heart disease and heart failure. However, the development of myosin-based therapeutics has been hampered by the lack of targeted in vitro screening assays. In this study we use Artificial Intelligence-based virtual high throughput screening (vHTS) to identify novel small molecule effectors of human β-cardiac myosin. We test the top scoring compounds from vHTS in biochemical counter-screens and identify a novel chemical scaffold called ‘F10’ as a cardiac-specific low-micromolar myosin inhibitor. Biochemical and biophysical characterization in both isolated proteins and muscle fibers show that F10 stabilizes both the biochemical (i.e. super-relaxed state) and structural (i.e. interacting heads motif) OFF state of cardiac myosin, and reduces force and left ventricular pressure development in isolated myofilaments and Langendorff-perfused hearts, respectively. F10 is a tunable scaffold for the further development of a novel class of myosin modulators.
Epidemiology, mortality, and health service use of local-level multimorbidity patterns in South Spain
Authors: Alvarez-Galvez Javier , Ortega-Martin Esther , Ramos-Fiol Begoña , Suarez-Lledo Victor , Carretero-Bravo Jesus 
Published: November 2023

AbstractMultimorbidity –understood as the occurrence of chronic diseases together– represents a major challenge for healthcare systems due to its impact on disability, quality of life, increased use of services and mortality. However, despite the global need to address this health problem, evidence is still needed to advance our understanding of its clinical and social implications. Our study aims to characterise multimorbidity patterns in a dataset of 1,375,068 patients residing in southern Spain. Combining LCA techniques and geographic information, together with service use, mortality, and socioeconomic data, 25 chronicity profiles were identified and subsequently characterised by sex and age. The present study has led us to several findings that take a step forward in this field of knowledge. Specifically, we contribute to the identification of an extensive range of at-risk groups. Moreover, our study reveals that the complexity of multimorbidity patterns escalates at a faster rate and is associated with a poorer prognosis in local areas characterised by lower socioeconomic status. These results emphasize the persistence of social inequalities in multimorbidity, highlighting the need for targeted interventions to mitigate the impact on patients’ quality of life, healthcare utilisation, and mortality rates.
A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer
Authors: Cui Chunyan , Mei Li , Wang Danyang , Jia Pengfei , Zhou Qihui , Liu Wenguang 
Published: November 2023

AbstractOral ulcer can be treated with diverse biomaterials loading drugs or cytokines. However, most patients do not benefit from these materials because of poor adhesion, short-time retention in oral cavity and low drug therapeutic efficacy. Here we report a self-stabilized and water-responsive deliverable coenzyme salt polymer poly(sodium α-lipoate) (PolyLA-Na)/coenzyme polymer poly(α-lipoic acid) (PolyLA) binary synergistic elastomer adhesive patch, where hydrogen bonding cross-links between PolyLA and PolyLA-Na prevents PolyLA depolymerization and slow down the dissociation of PolyLA-Na, thus allowing water-responsive sustainable delivery of bioactive LA-based small molecules and durable adhesion to oral mucosal wound due to the adhesive action of PolyLA. In the model of mice and mini-pig oral ulcer, the adhesive patch accelerates the healing of the ulcer by regulating the damaged tissue inflammatory environment, maintaining the stability of oral microbiota, and promoting faster re-epithelialization and angiogenesis. This binary synergistic patch provided a therapeutic strategy to treat oral ulcer.
Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer
Authors: Serebriiskii Ilya G. , Pavlov Valerii A. , Andrianov Grigorii V. , Litwin Samuel , Basickes Stanley , Newberg Justin Y. , Frampton Garrett M. , Meyer Joshua E. , Golemis Erica A. 
Published: November 2023

AbstractSomatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected and promote tumor aggressiveness has been controversial. Analysis of genomic data from ~53,000 CRCs indicates that hotspot mutation patterns in PTEN partially reflect DNA-dependent selection pressures, but also suggests a strong selection pressure based on protein function. In microsatellite stable (MSS) tumors, PTEN alterations co-occur with mutations activating BRAF or PI3K, or with TP53 deletions, but not in CRC with microsatellite instability (MSI). Unexpectedly, PTEN deletions are associated with poor survival in MSS CRC, whereas PTEN mutations are associated with improved survival in MSI CRC. These and other data suggest use of PTEN as a prognostic marker is valid in CRC, but such use must consider driver mutation landscape, tumor subtype, and category of PTEN alteration.
An intelligent framework for forecasting and investigating corrosion in marine conditions using time sensor data
Authors: Ben Seghier Mohamed El Amine , Knudsen Ole Øystein , Skilbred Anders Werner Bredvei , Höche Daniel 
Published: November 2023

AbstractCorrosion of marine steel structures can be regarded as a time-dependent process that might result in critical strength loss and, eventually, failures. The availability of reliable forecasting models for corrosion would be useful, enabling intelligent maintenance program management, and increasing marine structure safety, while lowering in-service expenses. In this study, an intelligent framework based on a data-driven model is developed that employs a group method of data handling (GMDH) type neural network to forecast free atmospheric corrosion as time-series problem. Therefore, data from sensor data with a 30-min interval over a 110 day period that includes free atmospheric corrosion as well as environmental factors are used. In addition, the Shapley additive explanations (SHAP) technique is used to investigate the impact of the surrounding environmental factors on free atmospheric corrosion. For the performance evaluation of the proposed intelligent framework, selected comparative metrics are used. Findings demonstrate the high accuracy and efficiency of the time series data-driven framework for tackling free atmospheric corrosion progression in marine environments.