bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Gut Microbiota on Thyroid Immune Responses - Evaluation with Bioinformatics Tools
Authors: Andrade Luís Jesuino de Oliveira , de Oliveira Gabriela Correia Matos , de Oliveira Luisa Correia Matos , Silva Catharina Peixoto , de Oliveira Luís Matos 
Published: October 2023

Abstract
Introduction
Perturbations in the composition and functionality of the gut microbiota have been implicated in various autoimmune diseases, including those affecting the thyroid gland. Despite significant advancements in understanding this association, there remains a gap in research regarding the precise mechanisms by which gut microbiota dysbiosis contributes to the development and progression of autoimmune thyroid disorders.
Objective
To investigate the influence of gut microbiota on thyroid immune responses using bioinformatics tool.
Methods
The study used genomic and proteomic sequence data from the NCBI database to examine the influence of gut microbiota on thyroid immune responses. Taxonomic analysis and metagenomic analysis were performed, and functional annotation tools were used to identify genes and pathways involved in the immune response. Biological networks were constructed to understand the complex biological interactions.
Results
A total of 944 sequences of microorganisms specific to thyroid immune response were obtained from NCBI. The taxonomic composition consisted of Agathobacter rectalis, Bacteroides stercoris, Bifidobacterium faecale, Clostridium coccoides, Clostridium leptum, Lactobacillus iners, Prevotella jejuni, and Roseburia. Bacteroides stercoris represented 35% of the composition, Agathobacter rectalis represented 25%, Prevotella jejuni represented 15%, and Roseburia represented 10%. The taxonomic diversity index was 0.85, indicating high diversity. Biological networks were constructed, revealing 8 significant modules. The NF-kB and MAPK signaling pathway was identified as the specific pathway influencing gut microbiota on thyroid immune responses, playing a critical role in modulating the immune response of the thyroid.
Conclusion
We identified a diverse set of microorganisms specific to the thyroid immune response, and through biological network analysis, we identified the signaling pathway as critical in modulating the immune response of the thyroid.
Genesis of Soviet Philosophy: the Case of V.F. Asmus
Authors: Климова С.М. 
Published: October 2023

В статье показан процесс становления советской философии в 1920-е гг. на примере анализа первой книги Валентина Фердинандовича Асмуса, опубликованной в 1924 г. и ее рецензий в эмигрантской и советской прессе. Центральным пунктом стало обсуждение теории познания, уточнение ее предмета и метода в марксистской философии. Диалектический метод, как главный объект анализа, был рассмотрен Асмусом через историко-философскую реконструкцию идей от Канта и Гегеля к Марксу и Ле-нину. При этом философия Ленина, чье имя значится в заголовке книги, оказалась, по сути, не затронута в исследовании Асмуса. Попутно он коснулся проблем первобытного мышления, античной диалектики и нового времени. Асмус доказывает, что подлинным предметом философии может быть только мышление в его диалектическом развитии (30 лет спустя эту позицию примется отстаивать Эвальд Ильенков). Вторая часть статьи посвящена критическим рецензиям на первую книгу Асмуса, как в эмигрантской, так и в советской прессе. Обращение к данному материалу позволяет реконструировать пространство интеллектуальной мысли, демонстрирующее процесс становления советской философии.
The article shows the process of formation of Soviet philosophy in the 20s through the analysis of Valentin Ferdinandovich Asmus’s first book, published in 1924, and its reviews in the émigré and Soviet press. The central point was a discussion of the theory of cognition, clarifying its subject and method in Marxist philosophy. The dialectical method, as the main object of analysis, was examined by Asmus through a historical and philosophical reconstruction of ideas from Kant and Hegel towards Marx and Lenin. Lenin’s name featured in the book’s title turns out to be essentially absent from the study itself. In passing, he touched upon the problems of primitive thinking, ancient dialectics and modern times. Asmus argues that only thinking taken in its dialectic development can be the true subject of philosophy (30 years later, Evald Ilienkov will assume this stance as well). The second part of the article considers critical responses to Asmus’s first books in both émigré and Soviet press. These data make it possible to reconstruct the course of intellectual thought that shaped the formation of Soviet philosophy.
America as a Pastoral and/or Barbaric Periphery in Two European Travelogues of the Eighteenth Century
Authors: Филимонова М.А. 
Published: October 2023

Соединенные Штаты на этапе становления своей государственности вызывали острый интерес европейских современников. Создаваемые ими образы заокеанской рес-публики, как правило, формировали идеализирующий и негативизирующий дискурсы в отношении США. В статье анализируются яркие примеры европейского восприятия ранней Америки: «Дневник благородной дамы» Дженет Шоу и «Новое путешествие по Соединенным Штатам» Жак-Пьера Бриссо.
The United States at the stage of the formation of its statehood aroused the keen interest of European contemporaries. The images they created of an overseas republic, as a rule, formed idealizing and negativizing discourses about the United States. This article analyzes vivid examples of the European perception of early America, Journal of a Lady of Qualityby Janet Schaw and Nouveau voyage dans les Etats-Unis de l’Amérique Septentrionale by Jacques-Pierre Brissot.
The Crisis of Culture in «The Burnt Novel» by Ya. E. Golosovker
Authors: Морозов Д.А. 
Published: October 2023

В статье художественное произведение Я.Э. Голосовкера «Сожженный роман», впервые опубликованное в 1991 году, рассматривается в качестве реализации его оригинального философского проекта. С опорой на трактат Голосовкера «Имагинативный абсолют» и другие работы автор рассматривает, как ключевые философские сюжеты отразились в творчестве мыслителя: идея познания воображением, противопоставление imaginatio и ratio, связь культуры и «духа», роль «смыслообразов». В данной интерпретации «Сожженный роман», события которого происходят во второй половине 1920-х гг., предстает диагнозом кризиса культуры, который Голосовкер ставит эпохе. Особое внимание уделено тому, как «Сожженный роман» встраивается в интеллектуальный контекст. В частности, как эстетика «молчаливого» Христа объединяет романы Достоевского, Булгакова и Голосовкера.
The article considers the artistic work by Ya.E. Golosovker «The Burnt Novel», first published in 1991, as an implementation of his original project of philosophy. Author, relying on the treatise «Imaginative Absolute», shows how the key philosophical themes were reflected in «The Burnt Novel»: idea of cognition by imagination, opposition of imaginatio and ratio, connection of culture and «spirit», role of «meaning images». «The Burnt novel», the events of which take place in the second half of the 20s of the XX century, in this interpretation appears as Golosovker’s diagnosis of crisis to culture. Special attention is paid to the embeddedness of «Burnt Novel» in the intellectual context. In particular, to the aesthetics of the «silent» Christ unites the novels of Dostoevsky, Bulgakov and Golosovker.
Professional Identity and Self-Consciousness of the Historian: Results and Prospects of the Study
Authors: Сидоров А.В. , Сидорова Л.А. 
Published: October 2023

Рассматривается содержание нового выпуска в серии «Профессия – историк», посвященного юбилею члена-корреспондента РАН, Президента Российского общества интеллектуальной истории Лорины Петровны Репиной[1]. Книга раскрывает актуальные тенденции развития исторической науки на современном этапе.
The content of the new issue in the "Profession – Historian" series dedicated to the anniversary of the chief researcher of the Institute of General History of the Russian Academy of Sciences, Professor, Corresponding member of the Russian Academy of Sciences, President of the Russian Society of Intellectual History Lorina Petrovna Repina is considered. The book reveals the current trends in the development of historical science at the present stage.
“The Original Has Long Been Lost…”: The German project of the first edition of Diderot’s satire “Ramo’s Nephew” and the mystery of its St. Petersburg manuscript
Authors: Лагутина И.Н. 
Published: October 2023

В статье на основе переписки, свидетельств современников и новых архивных документов исследуется появление на европейском книжном рынке «эрмитажной» копии сатиры Дидро «Племянник Рамо», а также реконструируются обстоятельства ее первого издания при участии немецких писателей Клингера, Шиллера и Гете.
Based on correspondence, testimonies of contemporaries and new archival documents, the article examines the appearance on the European book market of the "Hermitage" copy of Diderot's satire Rameau's Nephew, and also reconstructs the circumstances of its first edition with the participation of the German writers Klinger, Schiller and Goethe.
Carbon filtration: harnessing cotton's power to purify drinking water
Authors: Morad Salma , Abo Ali Siba , Diab Layan , Abedelrahman Rehan , Amar Faihaa , Asli Sare , Hugerat Muhamad , Said Inas , Diab Mahmud 
Published: October 2023

Abstract

Water pollution is a global concern, necessitating accessible and effective water treatment solutions. Our study focused on developing and evaluating carbonized cotton filters for methylene blue (MB) removal from drinking water. We examined the impact of carbonization parameters on filter performance, revealing significantly higher MB removal with carbonized filters compared to pure cotton. This improvement can be attributed to increased surface area, enhanced adsorption capacity, and altered chemical properties resulting from carbonization. We also tested the generality of the process using lentils and sesame, further demonstrating the versatility of carbonized cotton filters. Additionally, we assessed filter durability through multiple filtration cycles, confirming their consistent efficiency over time. Our findings underscore carbonized cotton filters’ efficacy and broad applicability for water purification, providing an affordable and sustainable solution to combat water pollution. This research advances water treatment technologies and advocates for using locally available resources to enhance water quality cost-effectively and eco-responsibly.
O ESTADO E A QUESTÃO DOS DEVOLUTOS
Authors: Mendes Luís 
Published: October 2023

Indiscutivelmente, um dos problemas que marcam a situação actual em Portugal e em Lisboa, no início deste ano de 2023, é sem dúvida a crescente dificuldade da população no acesso ao Direito à Habitação, corolário de uma crise estrutural do sector que se arrasta há décadas, intrínseca ao próprio funcionamento do modo de produção capitalista na sua materialidade portuguesa, e que se agudizou particularmente depois da crise capitalista de 2008-2009 e com a crise pandémica de 2020-2022 e agora ressurge com a crise inflacionária. O objectivo deste artigo é analisar o papel que o Estado e a Política Pública pode ter no sentido de alargar o acesso à habitação de vastas camadas da maioria social, mediante a mobilização de património público e privado devoluto para aumentar a oferta massiva de habitação acessível.
Palavras-chave: Estado, direito à habitação, política pública, devolutos.
Recent Advances in the Prevention and Management of Monkeypox Viral
Infection in Humans
Authors: Gujjar Preeti , Chaudhay Rishabh , Verma Inderjeet , Bansal Nitin , Gupta Sumeet , Bansal Seema 
Published: October 2023

Background:
There have been several neglected infectious pathogens that have reemerged
in the last few decades, including the monkeypox virus, a virus from the orthopoxviral
genus that causes monkeypox and is transmitted between animals and humans. The human monkeypox
outbreak has spread to several different countries. Because of the outbreak's unusually
high case count and lack of connections to endemic nations, there are concerns that the monkeypox
transmission pattern may have changed.

Objective:
The current study aimed to provide recent advancements in the prevention and management
of the monkeypox virus in humans.

Methodology:
We have highlighted recent advancements in the prevention and management of
the monkeypox virus in humans in this work.

Results:
For the treatment and prevention of monkeypox, new medications and vaccinations are
being used, and more study is needed to understand the epidemiology, biology, and ecology of the
virus in endemic regions and stop future global outbreaks. Vaccines available in the market for the
treatment of viruses are JYNEOS and ACAM2000. Some of the antiviral drugs, such as tecovirimat,
brincidofovir, cidofovir, trifluridine, and vaccinia immune globulin, are used for the treatment
of the monkeypox virus. Some of the vaccines, such as NIOCH-14, Cidofovir, CMX-001,
and ST-246, are currently in clinical trials.

Conclusion:
We have, herein, covered features of monkeypox viral biology that are important for
risk assessment and getting ready for an outbreak of the monkeypox virus, with a focus on recent
advances in knowledge of the virus's host range, evolutionary potential, and potential targets for
neutralization.
Exploring the Potential of Natural Products as Antiparasitic Agents for
Neglected Tropical Diseases
Authors: Orosco Dayanna , Mendoza Arturo René , Meléndez Carlos Mario 
Published: October 2023

Abstract:
Recent developments in the use of natural product-based molecules as antiparasitic
agents for Malaria, leishmaniasis (LE), Chagas disease (CD), and Human African trypanosomiasis
(HAT) are reviewed. The role of diverse plants in developing bioactive species is discussed in addition
to analyzing the structural diversity of natural products as active agents and the diverse biological
applications in CD, HAT, LE, and Malaria. This review focuses on medicinal chemistry,
emphasizing the structural characteristics of natural molecules as bioactive agents against parasitic
infections caused by Leishmania, Trypanosoma, and Plasmodium parasites.
Upgrading Melanoma Treatment: Promising Immunotherapies Combinations
in the Preclinical Mouse Model
Authors: Lara-Vega Israel 
Published: October 2023

Background:
Melanoma, known for its high metastatic potential, does not respond well to
existing treatments in advanced stages. As a solution, immunotherapy-based treatments, including
anti-PD-1/L1 and anti-CTLA-4, have been developed and evaluated in preclinical mouse models to
overcome resistance. Although these treatments display the potential to suppress tumor growth, there
remains a crucial requirement for a thorough assessment of long-term efficacy in preventing metastasis
or recurrence and improving survival rates.

Methods:
From 2016 onwards, a thorough examination of combined immunotherapies for the treatment
of cutaneous melanoma in preclinical mouse models was conducted. The search was conducted
using MeSH Terms algorithms in PubMed®, resulting in the identification of forty-five studies that
met the rigorous inclusion criteria for screening.

Results:
The C57 mouse model bearing B16-melanoma has been widely utilized to assess the efficacy
of immunotherapies. The combination of therapies has demonstrated a synergistic impact, leading
to potent antitumor activity. One extensively studied method for establishing metastatic models involves
the intravenous administration of malignant cells, with several combined therapies under investigation.
The primary focus of evaluation has been on combined immunotherapies utilizing PD-
1/L1 and CTLA-4 blockade, although alternative immunotherapies not involving PD-1/L1 and
CTLA-4 blockade have also been identified. Additionally, the review provides detailed treatment regimens
for each combined approach.

Conclusion:
The identification of techniques for generating simulated models of metastatic melanoma
and investigating various therapeutic combinations will greatly aid in evaluating the overall systemic
efficacy of immunotherapy. This will be especially valuable for conducting short-term preclinical
experiments that have the potential for clinical studies.
Advances in Non-thermal Food Processing Methods-Principle Advantages
and Limitations for the Establishment of Minimal Food Quality as well as
Safety Issues: A Review
Authors: Dangal Anish , Timsina Prekshya , Dahal Sangam , Rai Kishor , Giuffrè Angelo Maria 
Published: October 2023

Background:
The demand from consumers for safe, healthy food with a long shelf life,
with no change in taste or nutritive value, has made food safety a key concern in today's world.
Traditional thermal food processing technology has trouble meeting these standards. Conventional
thermal and non-thermal processing has limitations and to overcome these limitations more
studies are conducted regarding the novel non-thermal food processing methods.

Objective:
The goal of this paper was to present an overview of the research on the development
of non-thermal processing techniques, such as electrofreezing, high hydrostatic pressure, pulsed
electric fields, ultrasound, pulsed light, and plasma activated water, as well as their advantages
and limitations.

Methods:
The present review aims to summarize findings related to novel non-thermal processing
techniques, gathered from work published in scientific journals, related books, and book chapters
from sources such as Web of Science (WoS), Google Scholar, Scopus and ScienceDirect.

Results:
Non-thermal treatment may result in more desirable outcomes, such as greater preservation of heat-sensitive nutrients, fewer changes in sensorial as well as physico-chemical quality of
the processed foods.

Conclusion:
Compared to traditional heat processing, the nutritional value of foods is better preserved, and the sensory qualities of foods are less altered. These novel techniques can be combined with each other to achieve higher efficiency and overcome other limitations. More studies
should be conducted regarding the combination of novel non-thermal techniques to achieve
greater efficiency.
Age and Gender-related Morphometric Assessment and Degenerative Changes
of Temporomandibular Joint in Symptomatic Subjects and Controls using Cone
Beam Computed Tomography (CBCT): A Comparative Analysis
Authors: Hu Xiaoyin , Sujanamulk Bhavana , Lakshmi Chintamaneni Raja , Li Changhui 
Published: October 2023

Background:
The temporomandibular joint diseases have been associated with various predisposing factors. Joint spaces, articular eminence height and inclination, and the shapes of the condylar and glenoid fossa have all been shown to vary in TMD patients. Advanced imaging techniques like CBCT have been employed to estimate these parameters.

Aims and Objectives:
The aim of the current study was to investigate the condylar morphology, condylar and glenoid fossa shapes, and assessment of joint spaces, such
as anterior, posterior, superior, lateral, and medial spaces, through CBCT slices in coronal and sagittal planes and compare them between the
control group and TMD group.

Materials and Methods:
A cross-sectional study was planned where 80 joints in 40 patients were assessed for the above parameters; group I consisted of healthy patients, and group II included those with temporomandibular joint diseases (TMDs). The articular eminence height and inclination were assessed on the midsagittal section. The condylar changes and shapes of the glenoid fossa and condyles, as well as the joint spaces, were assessed on the selected coronal and sagittal sections.

Results:
The condylar fossa had a triangular shape in the TMJ group and an oval shape in the control group. The results were highly significant (P = 0.000**). A highly significant difference in morphological parameters such as AJS, PJS, SJS, MJS, LJS, articular eminence height, and inclination was found between the two groups (P = 0.000**). The association of morphological parameters such as AJS, PJS, SJS, MJS, LJS, articular eminence height and inclination were compared with condylar and glenoid fossa shapes, where the association of superior joint space and articular eminence inclination was observed. A highly significant difference was noted between the two groups with regards to all the parameters with P=0.00*.

Conclusion:
The articular eminence inclination as well as the superior joint space were found associated with the glenoid and condyle fossa shapes in the TMJ group. These observations would therefore help in the early diagnosis of temporomandibular joint diseases.
Blockchain Security Attacks, Difficulty, and Prevention
Authors: Jyoti Amrita , Yadav Vikash , Rahul Mayur 
Published: October 2023

:
Blockchain technology is increasingly attracting young people because it is so well
adapted to the digital age. A decentralised data management system is necessary for the blockchain
idea in order to store and share data and transactions throughout the network. This study
investigates various types of risks associated with blockchain technology. The research covers
different aspects of blockchain, including the architecture, consensus mechanism, smart contracts,
and underlying cryptographic algorithms. It also examines the risks associated with the
adoption and implementation of blockchain in various industries, such as finance, healthcare, and
supply chain management.

:
Moreover, this study identifies several types of risks, including technical risks, such as scalability,
interoperability, and security, as well as non-technical risks, such as regulatory compliance,
legal liability, and governance issues. This study also discusses the potential impact of these risks
on blockchain-based systems and the strategies that can be used to mitigate them.