bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colorectal cancer screening status and its association with health belief model variables in a rural population
Authors: Bateman Andre G. , Greeson Emily M. , Lowenstein Kathleen , Rodriguez Michael G. , Lyons James A. , Stack Matthew A. , O'Rourke Michael 
Published: October 2023

Abstract

Background:
Rural populations exhibit low colorectal cancer (CRC) screening rates, which may be a consequence of social determinants of health but may also result from individual health beliefs. This study aimed to explore the association between key health belief model (HBM) variables and CRC screening status in a rural Midwest population.

Methods:
One hundred thirty six people participated in this cross-sectional study. A survey instrument was developed to capture demographic information and measure the following HBM variables: perceived barriers, perceived benefits, self-efficacy beliefs associated with CRC screening, and knowledge associated with CRC.

Results:
The response rate for the study was 17.6%. The most endorsed (28.5%) barrier to CRC screening was fear of something going wrong. The most endorsed (86.5%) benefit of CRC screening was confidence that privacy and confidentiality would be protected. There were significant differences (P < .01) in means for perception of barriers, benefits, and self-efficacy according to CRC screening status. In a model which included perception of barriers, benefits, and self-efficacy, only perceived barriers made a unique, significant (P < .05) contribution (OR = 0.823 [0.706–0.958]) in predicting CRC screening status.

Conclusions:
Key HBM variables, perception of barriers, benefits, and self-efficacy seem to be important factors associated with CRC screening in rural populations and may be appropriate targets for interventions to increase CRC screening.
Low UPB1 Level Correlates With Poor Prognosis in Lung Adenocarcinoma
Authors: Zhang Libin , Liu Jun , Wang Han , Xu Zheyuan , Wang Yang , Chen Yun , Peng Hao 
Published: October 2023

Objectives:
Lung adenocarcinoma (LUAD) is a critical cancer with high mortality, worse prognosis, and crucial lymphatic metastasis. Consequently, prognostic biomarkers for LUAD are truly required. β-Ureidopropionase (UPB1) is abnormally expressed in various cancers. However, the function of UPB1 in LUAD is still ambiguous. This study aimed to explore the expression profile and prognostic significance of UPB1 in LUAD.

Materials and Methods:
The differential UPB1 levels in pan cancers and their prognostic significance were comprehensively investigated through Gene Expression Profiling Interactive Analysis, UALCAN, Tumor Immune Estimation Resource, and Kaplan-Meier plotter platform. The correlation between UPB1 and tumor infiltration immune cells was explored using Tumor Immune Estimation Resource, Gene Expression Profiling Interactive Analysis, and Tumor-Immune System Interactions and Drug Bank database databases.

Results:
The UPB1 level was abnormally expressed in pan-tumor tissue than in adjacent tissue from The Cancer Genome Atlas tool. Low UPB1 level was correlated with poor overall survival in patients with LUAD. Furthermore, a comparison of the various pathologic characteristics of LUAD between high and low UPB1 level subgroups revealed that low UPB1 expression was correlated with lymph node metastasis. Kaplan-Meier survival analysis indicated that a low UPB1 level was associated with worse progression‑free survival and overall survival in patients with LUAD. Univariate and multivariate analyses suggested that UPB1 could be a useful prognostic indicator for LUAD. Abnormal UPB1 may be correlated with aberrant LUAD immune infiltration, prompting a worse survival outcome.

Conclusions:
Results showed that low UPB1 is correlated with a worse prognosis of LUAD and may be a valuable prognostic indicator for LUAD.
Management of Biofilm with Breast Implant Surgery
Authors: Myckatyn Terence M. , Duran Ramirez Jesus M. , Walker Jennifer N. , Hanson Blake M. 
Published: October 2023

Learning Objectives:
After studying this article, the participant should be able to: 1. Understand how bacteria negatively impact aesthetic and reconstructive breast implants. 2. Understand how bacteria infect breast implants. 3. Understand the evidence associated with common implant infection-prevention strategies, and their limitations. 4. Understand why implementation of bacteria-mitigation strategies such as antibiotic administration or “no-touch” techniques may not indefinitely prevent breast implant infection.

Summary:
Bacterial infection of aesthetic and reconstructive breast implants is a common and expensive problem. Subacute infections or chronic capsular contractures leading to device explantation are the most commonly documented sequelae. Although bench and translational research underscores the complexities of implant-associated infection, high-quality studies with adequate power, control groups, and duration of follow-up are lacking. Common strategies to minimize infections use antibiotics—administered systemically, in the breast implant pocket, or by directly bathing the implant before insertion—to limit bacterial contamination. Limiting contact between the implant and skin or breast parenchyma represents an additional common strategy. The clinical prevention of breast implant infection is challenged by the clean-contaminated nature of breast parenchyma, and the variable behavior of not only specific bacterial species but also their strains. These factors impact bacterial virulence and antibiotic resistance.
Prosthetic device and service satisfaction, quality of life, and functional performance in lower limb prosthesis clients
Authors: DadeMatthews Oluwagbemiga O. , Roper Jaimie A. , Vazquez Adan , Shannon David M. , Sefton JoEllen M. 
Published: October 2023

Objective:
The aim of this study was to characterize the relationship between prosthetic device and service satisfaction, health-related quality of life (HRQOL), and functional movement in a diverse population of lower limb prosthesis users.

Methods:
An online survey was conducted on individuals with lower limb amputation between September and October 2021. Sample validated questionnaires assessing demographic and clinical features, satisfaction, functional outcomes, and quality of life were analyzed using path analysis.

Results:
Participants were 1736 individuals with lower limb amputation. Overall, 44% of participants reported dissatisfaction with prosthetic device, whereas 37% were dissatisfied with prosthetic service. Low functional mobility was reported by 58% of participants and 61% reported low HRQOL. Lower extremity functional status (β = 0.55), HRQOL (β = 0.08), Activities-specific Balance Scale (β = 0.22), and modified fall efficacy scale (β = −0.07) are significantly associated with prosthetic device satisfaction (P < 0.0005, R2 = 0.47). Satisfaction with provider service was significantly associated with lower extremity functional status (β = 0.44) and balance confidence (β = 0.18) (P < 0.0005, R2 = 0.34).

Conclusion and Clinical Relevance:
Civilians, veterans, and service members reported low functional mobility, low quality of life, and moderate levels of dissatisfaction with their lower extremity prosthetic device and provider service. Improvements in mobility, balance, quality of life, and fall efficacy may enhance device satisfaction. Functional mobility and balance improvements may increase ratings of provider service. This study provides feedback that may improve clinical decisions on lower limb prosthesis patient care.
ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Β3
Authors: Zhang Yu , Wang Yan , Li Jiao , Li Chaofu , Liu Weiwei , Long Xianping , Wang Zhenglong , Zhao Ranzun , Ge Junbo , Shi Bei 
Published: October 2023

ABSTRACT
Cardiac macrophages with different polarization phenotypes regulate ventricular remodeling and neovascularization after myocardial infarction (MI). Annexin A2 (ANXA2) promotes macrophage polarization to the repair phenotype and regulates neovascularization. However, whether ANXA2 plays any role in post-MI remodeling and its underlying mechanism remains obscure. In this study, we observed that expression levels of ANXA2 were dynamically altered in mouse hearts upon MI and peaked on the second day post-MI. Using adeno-associated virus vector–mediated overexpression or silencing of ANXA2 in the heart, we also found that elevation of ANXA2 in the infarcted myocardium significantly improved cardiac function, reduced cardiac fibrosis, and promoted peri-infarct angiogenesis, compared with controls. By contrast, reduction of cardiac ANXA2 exhibited opposite effects. Furthermore, using in vitro coculture system, we found that ANXA2-engineered macrophages promoted cardiac microvascular endothelial cell (CMEC) proliferation, migration, and neovascularization. Mechanistically, we identified that ANXA2 interacted with yes-associated protein (YAP) in macrophages and skewed them toward pro-angiogenic phenotype by inhibiting YAP activity. In addition, ANXA2 directly interacted with integrin β3 in CMECs and enhanced their growth, migration, and tubule formation. Our results indicate that increased expression of ANXA2 could confer protection against MI-induced injury by promoting neovascularization in the infarcted area, partly through the inhibition of YAP in macrophages and activation of integrin β3 in endothelial cells. Our study provides new therapeutic strategies for the treatment of MI injury.
TERLIPRESSIN COMBINED WITH NOREPINEPHRINE IN THE TREATMENT OF SEPTIC SHOCK: A SYSTEMATIC REVIEW
Authors: Mao Fengkai , Liang Dongcheng , Tang Zewen , Xu Yuxuan , Lin Leqing 
Published: October 2023

ABSTRACT

Objective: The objective of this study was to provide an in-depth analysis of the advantages and potential research directions concerning the utilization of terlipressin (TP) in combination with norepinephrine (NE) for the management of septic shock. Methods: A systematic search was conducted across five major electronic databases, namely, PubMed, Cochrane, Embase, ScienceDirect, and MEDLINE, using the Boolean method. The search encompassed articles published until May 22, 2023. Randomized controlled trials investigating the efficacy of TP combined with NE in the treatment of patients with septic shock were considered for inclusion. Results: A total of seven trials met the inclusion criteria. The combination therapy of TP and NE exhibited potential benefits in the treatment of adult patients suffering from septic shock. Furthermore, the concurrent administration of TP with NE demonstrated improvements in cardiac output and central venous pressure. However, it is important to acknowledge the presence of certain risks and potential adverse events, including an elevated risk of peripheral ischemia. Conclusions: The available evidence supports the notion that early combination therapy involving NE and TP holds promise in terms of reducing the required dosage of NE, enhancing renal perfusion, and improving microcirculation in patients diagnosed with septic shock.
Association of Prophylactic Antibiotics With Early Infectious Complications in Children With Cancer Undergoing Central Venous Access Device Placement
Authors: Papastefan Steven T. , Zeineddin Suhail , Blakely Martin L. , Lovvorn Harold N. , Huang Lynn Wei , Raval Mehul V. , Lautz Timothy B. 
Published: October 2023

Objective:
To evaluate the impact of prophylactic antibiotics on early infectious complications after central venous access device (VAD) placement in children with cancer.

Background:
Despite the frequency of VAD procedures in children, the effectiveness of prophylactic antibiotics for reducing infectious complications is unknown.

Methods:
This was a retrospective cohort study of children with cancer undergoing central VAD placement identified in the Pediatric Health Information System database between 2017 and 2021. The primary outcome was the rate of early infectious complications (composite surgical site infections, central line-associated bloodstream infections, and bacteremia). Multivariable logistic regression was used to evaluate factors associated with early infection, and heterogeneity of treatment effect of prophylactic antibiotics was compared across subgroups.

Results:
A total of 9216 patients were included (6058 ports and 3158 tunneled lines). Prophylactic antibiotics were associated with lower early infectious complications overall [1.3% vs 2.4%; odds ratio (OR): 0.55 (95% CI: 0.39–0.79), P < 0.001], an effect demonstrated for tunneled lines (OR: 0.59, 95% CI: 0.41–0.84) but not ports (OR: 3.01, 95% CI: 0.66–13.78). On multivariate analysis, prophylactic antibiotics (OR: 0.67, 95% CI: 0.45–0.97) and solid tumors (OR: 0.38, 95% CI: 0.22–0.64) were associated with reduced odds of early infections, whereas tunneled lines (OR: 20.78, 95% CI: 9.83–43.93) and acute myelogenous leukemia (OR: 2.37, 95% CI: 1.58–3.57) had increased odds.

Conclusions:
Prophylactic antibiotics are associated with reduced early infectious complications after central VAD placement overall. Despite recommendations from multiple national organizations against prophylactic antibiotics, these findings suggest a benefit in children with malignancy undergoing tunneled line placement.
Progression of Site-specific Recurrence of Pancreatic Cancer and Implications for Treatment
Authors: Rompen Ingmar F. , Levine Jonah , Habib Joseph R. , Sereni Elisabetta , Mughal Nabiha , Hewitt Daniel Brock , Sacks Greg D. , Welling Theodore H. , Simeone Diane M. , Kaplan Brian , Berman Russell S. , Cohen Steven M. , Wolfgang Christopher L. , Javed Ammar A. 
Published: October 2023

Objective:
To analyze postrecurrence progression in the context of recurrence sites and assess implications for postrecurrence treatment.

Background:
Most patients with resected pancreatic ductal adenocarcinoma (PDAC) recur within 2 years. Different survival outcomes for location-specific patterns of recurrence are reported, highlighting their prognostic value. However, a lack of understanding of postrecurrence progression and survival remains.

Methods:
This retrospective analysis included surgically treated patients with PDAC at NYU Langone Health (2010–2021). Sites of recurrence were identified at the time of diagnosis and further follow-up. Kaplan-Meier curves, log-rank test, and Cox regression analyses were applied to assess survival outcomes.

Results:
Recurrence occurred in 57.3% (196/342) patients with a median time to recurrence of 11.3 months (95% CI: 12.6–16.5). The first site of recurrence was local in 43.9% of patients, liver in 23.5%, peritoneal in 8.7%, lung in 3.6%, whereas 20.4% had multiple sites of recurrence. Progression to secondary sites was observed in 11.7%. Only lung involvement was associated with significantly longer survival after recurrence compared with other sites (16.9 vs 8.49 months, P = 0.003). In local recurrence, 21 (33.3%) patients were alive after 1 year without progression to secondary sites. This was associated with a CA19-9 of <100 U/mL at the time of primary diagnosis (P = 0.039), nodal negative disease (P = 0.023), and well-moderate differentiation (P = 0.042) compared with patients with progression.

Conclusion:
Except for lung recurrence, postrecurrence survival after PDAC resection is associated with poor survival. A subset of patients with local-only recurrence do not quickly succumb to systemic spread. This is associated with markers for favorable tumor biology, making them candidates for potential curative re-resections when feasible.
Duration of Dialysis in Acute Kidney Injury Donors and Transplant Outcomes
Authors: Punukollu Rachana , Ohara Stephanie , Budhiraja Pooja , Smith Maxwell L , Kumm Kayla , Ruch Brianna , Misra Suman , Reddy Kunam S , Heilman Raymond , Jadlowiec Caroline C 
Published: October 2023

Background:
Acute kidney injury (AKI) kidneys, including those from donors on dialysis, are often underutilized, although there is increasing data available demonstrating good transplant outcomes. To date, data on the duration of donor dialysis and transplant outcomes are limited.

Study design:
This was a single-center study of deceased donor kidney transplants (DDKT) from 2010 to 2022. The study cohort consisted of recipients of DDKT from donors with AKI and on dialysis. Three groups were identified based on the predetermined interquartile range of donor dialysis duration: a) 1-2 dialysis days, b) 3-4 dialysis days, and c) ≥5 dialysis days.

Results:
During this period, 765 AKI DDKT were performed, of which 230 were from donors on dialysis. The median dialysis duration was two days with a maximum of 13 days. Across the three groups, there were no differences in recipient age (p=0.23) or dialysis vintage (p=0.70). Donor age (p=0.86) and KDPI (p=0.57) were comparable between the groups. DDKT from donors on dialysis ≥5 days had lower terminal creatinine levels (p=0.003) and longer cold ischemia times (p=0.04). Post-transplant, the median length of hospital stay was 3 days for all groups (p=0.75). There were no differences in delayed graft function occurrence (94.4% vs. 86.8% vs. 92.1%, p=0.19), duration of DGF (p=0.56) or readmissions (p=0.99). At one-year, the estimated glomerular filtration rate (p=0.76), patient survival (p=0.82), or death-censored graft survival (p=0.28) were comparable.

Conclusions:
Excellent outcomes have been observed in AKI DDKT, including those coming from donors on dialysis. In this small cohort, the duration of donor dialysis did not adversely affect outcomes. Cautious expansion of the donor pool, including donors on dialysis, should be considered given the ongoing organ shortage.
Threat of mining to African great apes
Authors: Junker Jessica , Quoss Luise , Valdez Jose , Arandjelovic Mimi , Barrie Abdulai , Campbell Genevieve , Heinicke Stefanie , Humle Tatyana , Kouakou Célestin Yao , Kühl Hjalmar S. , Ordaz-Nemeth Isabel , Pereira Henrique M. , Rainer Helga , Refisch Johannes , Sonter Laura , Sop Tenekwetche 
Published: October 2023

AbstractThe rapid growth of clean energy technologies is driving a rising demand for critical minerals. In 2022 at the UN Biodiversity Conference (COP 15), seven major economies formed an alliance to enhance the sustainability of mining these essential decarbonization minerals. However, there is a scarcity of studies assessing the threat of mining to global biodiversity. By integrating a global mining dataset with ape density distribution estimates, we explored the potential negative impact of industrial mining on African great apes. Our findings reveal that up to one-third of Africa’s great ape population faces mining-related risks. This is especially pronounced in West Africa, where numerous mining areas overlap with fragmented ape habitats, often occurring in high-density ape regions. For 97% of mining areas, no ape survey data are available, underscoring the importance of increased accessibility to environmental data within the mining sector to facilitate research into the complex interactions between mining, climate, biodiversity and sustainability.TeaserMining for clean energy minerals could put one-third of Africa’s ape population at risk.
A gene selection analysis of TAS1R1 and TAS1R3 to examine human carnivory
Authors: Cross Mackenzie , Kitchen Andrew 
Published: October 2023

ABSTRACTHumans are considered to have a unique reliance on meat compared to other primates, as much of humans unique evolutionary trajectory, such as human brain expansion, is linked to the increased consumption of meat for calories and nutrients. However, other primates such as chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) are also known to consume meat. While humans meat consumption is considered to be unique in humans’ increased incorporation of tools to process the prey carcass and consumption of a broader range of prey, these distinctions are less obvious when contextualized within the broader behavioral repertoire ofPanspecies carnivory. This research seeks to identify if the taste perception of meat is different between humans and other ape clades through gene selection analyses. Specifically, this work examines the umami taste receptor genes, TAS1R1 and TAS1R3, which enable the savory flavor perceived when eating meat. Using PAML, we test for positive selection in these genes across several ape clades. We infer positive selection in TAS1R1 for the homininae clade and positive selection in TAS1R3 for theHomo/Panclade. No selection was detected in only the human lineage, which complicates claims that human carnivory is unique compared to other primates while simultaneously suggesting the role of meat may be unappreciated in chimpanzees and bonobos as well as the role of insectivory in gorillas.
dismo: building and analysing discrete spatial ODE models
Authors: van Aalst Marvin , Ebenhöh Oliver 
Published: October 2023

AbstractSummarydismois a Python package for building and analysing discrete spatial models based on ordinary differential equations. Its primary purpose is to allow arbitrarily complex internal and transport processes to easily be mapped over multiple different regular grids. For this it features one, two and threedimensional layouts, with standard and non-standard (e.g. hexagonal or triangular) grids.Availability and implementationhttps://gitlab.com/qtb-hhu/dismoContactoliver.ebenhoeh@hhu.de
Biological Function of Exosome-like Particles Isolated from Rose (Rosa Damascena) Stem Cell Culture Supernatant
Authors: Won Yu Jin , Lee Esther , Min Seon Young , Cho Byong Seung 
Published: October 2023

AbstractRose stem cell (RSC) extracts have been claimed to have multiple beneficial effects in skin. Many cells release extracellular vesicles, also called exosomes, that involved in cell-to-cell communication. There is however no information on whether exosomes are released in RSC cultures, and what the biological function of these may be. We hypothesized that RSC in culture can release exosome-like particles (RSCEs) and that the RSCEs may have biological function in cells relevant to skin. RSC culture supernatant was purchased and standard exosome-isolation was performed, using tangential flow filtration. The characterization of RSCEs was measured with TEM and NTA, that revealed round structures and reports the presence of particles approximate 90-200nm size. Proteins and miRNAs were isolated from the exosomes, and 206 peptides containing likely cytosolic and membrane proteins and miRNA containing Let-7 families were identified. The RSCEs were found to be non-toxic on human dermal papilla cells, whereas a high concentration of the crude supernatant induced widespread cell death. Further, the RSCEs enhanced growth of human dermal fibroblasts and increased the closure of scratch assay, whereas the crude supernatant lacked this effect. Further, the RSCEs reduce the amount of melanin in cultured melanocytes and IL-6 released by Raw264.7 cells stimulated by LPS in a dose-dependent manner. These data collectively show that RSC in culture released RSCEs that contain miRNA and proteins have multiple biological functions in skin-related assays such as fibroblast growth and melanin content in melanocytes. Combined with the anti-inflammatory function of the RSCEs, we suggest that they have appropriate features to be useful in aesthetic medicine for improving skin quality.