bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actor roles emergence through actor engagement: an SD logic perspective
Authors: Wajid Anees , Paracha Osman Sadiq , Raziq Muhammad Mustafa 
Published: October 2023

Purpose
Emergence is a key concept in service-dominant (SD) logic; however, the literature is neonatal on the underlying mechanisms that lead to emergence within service ecosystems. This study aims to address the call by Vargo et al. (2022) for understanding the role of actor engagement in emergence of novel outcomes, by identifying a process of how various actor roles in entrepreneurial ecosystem (EE) emerge as resource through the actor engagement.

Design/methodology/approach
Following a longitudinal design, this study conduct interviews from 20 respondents over eight months in three phases (group interviews, post-training, post-funding). This study analyzes the respondents’ engagement in an entrepreneurial service context. This study uses qualitative inductive approach and thematic analysis.

Findings
Results show that actor roles emerge as role expectations from essential provider and beneficiary position in a service ecosystem through actor role readiness, manifested as engagement properties in the actor engagement process. This study identifies five actor roles and their corresponding role readiness dimensions that emerge. Based on these propositions through which the authors position generic actor roles emergence within the actor engagement process in a service ecosystem.

Originality/value
This paper advances the understanding of micro-level process in emergence literature in SD logic by providing a conceptual understanding of emergence of actor roles as a resource through actor engagement. By grounding the study in EE, this study provides empirical evidence to the underlying mechanisms at the micro level of resource emergence process in a service ecosystem.
Cashless Vietnam: a study on intention and adoption of cashless payment
Authors: Dieu Huynh Thi My , Al Mamun Abdullah , Nguyen Thi Le Huyen , Naznen Farzana 
Published: October 2023

Purpose
This study aims to identify factors that affect the intention and actual adoption of cashless payment (ACP) among Vietnamese youths. Extending the unified theory of acceptance and use of technology (UTAUT) model with two impelling factors (perceived trust [PTR] and lifestyle compatibility [LCM]), this study also examined the mediating effect of intention to adopt cashless payment (ICP) on the relationships of UTAUT model components with the actual ACP.

Design/methodology/approach
All data were collected online from 422 Vietnamese youths through online survey, and partial least squares structural equation modelling was performed to analyse the data.

Findings
The study’s results illustrated the positive and significant effects of performance expectancy, effort expectancy, facilitating conditions, LCM and PTR on ICP. However, social influence was found to exhibit a negative effect on ICP. Furthermore, ICP was found to contribute no mediation effects on the relationships of any of the components with the actual ACP.

Practical implications
This study’s findings are widely useful for marketers and managers to plot their promotional and campaigning strategies, emphasising factors that motivate consumers to adopt cashless payment. The obtained findings also benefit architects and designers in designing products and services by consolidating lifestyle standards and other requirements of consumers. Policymakers should implement policies and strategies to enforce rules and educate the public to widely adopt cashless payment across various sectors.

Originality/value
This study extended the UTAUT model with two new variables, i.e. PTR and LCM.
Circ_0026579 knockdown ameliorates lipopolysaccharide‐induced human lung fibroblast cell injury by regulating CXCR1 via miR‐370‐3p
Authors: Zhuang Yuanhong , Yang Yuyun , Peng Lihong 
Published: October 2023

AbstractPneumonia is an inflammatory disease in lower respiratory tracts and its development involves the regulation of RNAs. Circular RNAs are a class of RNA subgroups that can mediate the progression of pneumonia. However, the molecular mechanism of circ_0026579 in regulating pneumonia occurrence remains unclear. The study is designed to reveal the role of circ_0026579 in lipopolysaccharide (LPS)‐induced human lung fibroblast cell injury and the underlying mechanism. The expression levels of circ_0026579, miR‐370‐3p and C‐X‐C motif chemokine receptor 1 (CXCR1) were detected by quantitative real‐time polymerase chain reaction or by western blotting. The production of tumour necrosis factor‐α, interleukin (IL)‐1β and IL‐6 was assessed by enzyme‐linked immunosorbent assays. Malondialdehyde and superoxide dismutase levels were analysed using commercial kits. Cell viability, proliferation and apoptosis were analysed by cell counting kit‐8 assay, 5‐Ethynyl‐2′‐deoxyuridine assay and flow cytometry analysis, respectively. The binding relationship between miR‐370‐3p and circ_0026579 or CXCR1 was identified by dual‐luciferase reporter assay, RNA immunoprecipitation assay and RNA pull‐down assay. Circ_0026579 and CXCR1 expression were significantly upregulated, whereas miR‐370‐3p was downregulated in the serum of pneumonia patients. LPS treatment induced inflammatory response, oxidative stress and cell apoptosis and inhibited cell proliferation in MRC‐5 cells; however, these effects were reversed after circ_0026579 depletion. In terms of the mechanism, circ_0026579 acted as a miR‐370‐3p sponge, and miR‐370‐3p combined with CXCR1. Additionally, circ_0026579 depletion ameliorated LPS‐induced MRC‐5 cell disorder by increasing miR‐370‐3p expression. CXCR1 overexpression also relieved the miR‐370‐3p‐mediated effects in LPS‐treated MRC‐5 cells. Further, circ_0026579 induced CXCR1 expression by interacting with miR‐370‐3p. Circ_0026579 absence ameliorated MRC‐5 cell dysfunction induced by LPS through the regulation of the miR‐370‐3p/CXCR1 axis.
Community banks' capital requirements and regional housing tenure
Authors: Yang Chenzi , Moreira Fernando , Archibald Thomas Welsh 
Published: October 2023

AbstractBank capital requirements aim at reducing the likelihood of banks' failure. However, these policies may generate externalities on the overall economy. By investigating the pathways from capital requirements to housing tenure using structural equation modelling, we show that community banks' capital requirements increase the gap between the regional real estate loans‐based and non‐real estate loans‐based housing purchase rate and act as driving factors of housing market imbalance. The drop in residential real estate loans caused by the increase in capital requirements has two opposite effects: the direct effect motivates residents to rent properties, while the indirect effect motivates residents to purchase them due to the fall in housing prices. When both effects exist in housing purchases with real estate loans, the former effect is more influential than the latter one. Our findings suggest that the impact of capital requirements on housing tenure will depend on residents' reliance on real estate loans. If a housing purchase requires real estate loans, capital requirements will have a negative impact on the housing purchase, and vice versa.
Price predictability in liquid funds with illiquid underlying assets
Authors: Hughes William T. , Ling David C. , Ray Sugata , Xu Luqi 
Published: October 2023

AbstractDaily‐priced real estate (DPRE) funds are designed to provide investors with daily liquidity while investing in illiquid private assets. DPRE fund returns are predictable, allowing for a trading strategy based on predicted returns to generate trading profits of 60–132 bps a year. Funds with higher predicted returns have higher investor flows, but the flow‐to‐future predicted performance relationship is no stronger for DPRE funds with higher return predictability than those with lower return predictability. This appears to be the result of trading constraints on highly predictable institutional DPRE funds. Even modest trading restrictions on monthly redemptions render profits from trading strategies based on return predictability economically insignificant.
A case report of extra‐articular manifestation of rheumatoid arthritis: Rheumatoid nodules in lungs
Authors: Bektyrganova Saltanat , Kozhakhmet Doskhan , Kim Alexey , Baigenzhin Abay , Togizbayev Galymzhan , Doszhan Ainur , Krivoruchkо Natalya , Pak Alexey , Peradze Manana , Sarsengaliyev Timur 
Published: October 2023

AbstractRheumatoid arthritis is a systemic inflammatory disorder primarily affecting joints but not limited to the joints alone. Extra‐articular manifestations involve skin, ocular, gastrointestinal, pulmonary, cardiac, renal, neurological, and hematological systems. Among them, skin manifestations (20%) are most common, presenting as nodules on the extensor surfaces of the upper and lower extremities. In rare cases these nodules can also be detected within the heart and lungs. Interestingly, rheumatoid nodules are often seen in patients on leflunomide, methotrexate, or tumor necrosis factor‐alpha antagonists. Nevertheless, definitive diagnosis requires a histopathological analysis. In this case report, we presented a 49‐year‐old male patient with a relatively short period of disease activity leading to rheumatoid nodules in the lungs. Considering the ongoing COVID‐19 pandemic and that tuberculosis was still endemic in Kazakhstan, achieving the definite diagnosis was challenging. Initial imaging study revealed bilateral polysegmental pneumonia. The tests for COVID‐19 and pulmonary tuberculosis were negative. A follow‐up chest computed tomography scan had signs of disseminated lung lesions of unknown origin. Lung biopsy showed a morphological picture of productive granulomas characteristic for tuberculosis. However, at the second look, typical scarring granulomas typically seen in rheumatoid nodules were observed.
Intersection clock reveals a rejuvenation event during human embryogenesis
Authors: Kerepesi Csaba , Gladyshev Vadim N. 
Published: October 2023

AbstractRecent research revealed a rejuvenation event during early development of mice. Here, by examining epigenetic age dynamics of human embryogenesis, we tested whether a similar event exists in humans. For this purpose, we developed an epigenetic clock method, the intersection clock, that utilizes bisulfite sequencing in a way that maximizes the use of informative CpG sites with no missing clock CpG sites in test samples and applied it to human embryo development data. We observed no changes in the predicted epigenetic age between cleavage stage and blastocyst stage embryos; however, a significant decrease was observed between blastocysts and cells representing the epiblast. Additionally, by applying the intersection clock to datasets spanning pre and postimplantation, we found no significant change in the epigenetic age during preimplantation stages; however, the epigenetic age of postimplantation samples was lower compared to the preimplantation stages. We further investigated the epigenetic age of primed (representing early postimplantation) and naïve (representing preimplantation) pluripotent stem cells and observed that in all cases the epigenetic age of primed cells was significantly lower than that of naïve cells. Together, our data suggest that human embryos are rejuvenated during early embryogenesis. Hence, the rejuvenation event is conserved between the mouse and human, and it occurs around the gastrulation stage in both species. Beyond this advance, the intersection clock opens the way for other epigenetic age studies based on human bisulfite sequencing datasets as opposed to methylation arrays.
Origin and distribution pattern of pelvic limb nerves of a Bengal tiger (Panthera tigris tigris)
Authors: Sánchez Hilda Liliana , Massone Norberto , Alarcón Francisco , Rafasquino Marta Emilia , Diorio Juan José , Zuccolilli Gustavo , Portiansky Enrique Leo 
Published: October 2023

AbstractThe Bengal tiger (Panthera tigris tigris) is a species belonging to the Felidae family. In Argentina, tigers are currently only found in captivity. The longevity of individual animals in human‐controlled environments depends on proper management and practices that prioritize animal welfare. Regular veterinary care is essential to maintain optimal health conditions. Professionals must have a comprehensive understanding of the anatomy and physiology of tigers to effectively perform medical procedures and administer treatments. The study described in the text focuses on the trajectory and distribution of nerves in the pelvic limb of a Bengal tiger specimen, providing detailed dissection findings. The results revealed that the lumbosacral plexus is formed from the ventral rami of the LIV, LV, LVI, LVII, SI, SII and SIII nerves. Among the observations to highlight is the great development of the nerves N. cutaneus femoris lateralis and N. cutaneus femoris caudalis some differences were observed in the distribution of the N. femoralis and N. obturatorius; the N. ischiadicus, together with its division into the fibularis communis and tibialis nerves, showed the same configuration observed in other cats. Finally, it was observed that the nerves N. gluteus cranialis and N. gluteus caudalis also originated from the truncus lumbosacralis. The similarities and differences with studies carried out on other cats are relevant and provide anatomical data for medical procedures in the Bengal tiger.
Potential measurement error from vessel reflex and multiple light paths in dual‐wavelength retinal oximetry
Authors: Beach James M. , Shoemaker Benjamin , Eckert George J. , Harris Alon , Siesky Brent , Arciero Julia C. 
Published: October 2023

AbstractPurposeThis study aims to characterize the dependence of measured retinal arterial and venous saturation on vessel diameter and central reflex in retinal oximetry, with an ultimate goal of identifying potential causes and suggesting approaches to improve measurement accuracy.MethodsIn 10 subjects, oxygen saturation, vessel diameter and optical density are obtained using Oxymap Analyzer software without diameter correction. Diameter dependence of saturation is characterized using linear regression between measured values of saturation and diameter. Occurrences of negative values of vessel optical densities (ODs) associated with central vessel reflex are acquired from Oxymap Analyzer. A conceptual model is used to calculate the ratio of optical densities (ODRs) according to retinal reflectance properties and single and double‐pass light transmission across fixed path lengths. Model‐predicted values are compared with measured oximetry values at different vessel diameters.ResultsVenous saturation shows an inverse relationship with vessel diameter (D) across subjects, with a mean slope of −0.180 (SE = 0.022) %/μm (20 < D < 180 μm) and a more rapid saturation increase at small vessel diameters reaching to over 80%. Arterial saturation yields smaller positive and negative slopes in individual subjects, with an average of −0.007 (SE = 0.021) %/μm (20 < D < 200 μm) across all subjects. Measurements where vessel brightness exceeds that of the retinal background result in negative values of optical density, causing an artifactual increase in saturation. Optimization of model reflectance values produces a good fit of the conceptual model to measured ODRs.ConclusionMeasurement artefacts in retinal oximetry are caused by strong central vessel reflections, and apparent diameter sensitivity may result from single and double‐pass transmission in vessels. Improvement in correction for vessel diameter is indicated for arteries however further study is necessary for venous corrections.
The modeling pastes of the monumental terracruda sculpture of the Silk Roads: Archaeometric study of the Tepe Narenj and Qol‐e‐tut examples (Kabul, Afghanistan)
Authors: López‐Prat Monica , De Luca Raffaella , Pecci Alessandra , Mileto Simona , Bandyopadhyay Sudipa Ray , Bloise Andrea , Guido Adriano , Cipriani Mara , Lancelotti Carla , Carrascosa Begoña , Noori Noor Agha , Simón‐Cortés José‐Manuel , Miriello Domenico 
Published: October 2023

AbstractThis paper presents the results of the mineralogical, petrographic and chemical study of different archaeological samples related to terracruda sculptures and other elements that were part of the architectural decoration of the Buddhist sites of Tepe Narenj and Qol‐e‐tut (Kabul, Afghanistan; fifth to 11th centuries CE). The main objective of the study was to characterize the samples using an archaeometric approach. The study helped to better understand the materials involved in the modeling of Afghan sculptures and their processing, such as the different nature of the clay layers and the finishing ‘stucco’ coating. The results further indicate that similarities exist among the manufacturing process of the studied samples and that used today by an ancient caste of clay artists in West Bengal (India), suggesting the existence of a continuous technological tradition that deserves to be further explored in the future.
Tricky technology of making silver seed beads in the Early Bronze Age, NW Caucasus
Authors: Trifonov Viktor , Shishlina Natalia , Loboda Anastasia , Khvostikov Vladimir , Kovalenko Eketerina , Tereschenko Elena , Yatsishina Ekaterina 
Published: October 2023

AbstractThis study reconstructed the technical chaîne operatoire of silver seed bead production in the Maikop culture on the basis of tracewear analysis and experimental research using silver beads from the Early Bronze Age dolmen (c. 3200–2900 bce) in kurgan 2 at Tsarskaya (1898). The results demonstrate that such beads were produced as a “garland” lost wax casting, when a garland of beads is formed on a hollow dry stalk (straw) that burns out during the casting process. The technology of “garland” casting is an original and, probably, the earliest solution in history that helped address the issue of large‐scale production of uniform cast precious metal seed beads. It is not yet clear whether this technology was originally developed in the Caucasus or brought here from Western Asia, where the Maikop culture has its roots.
Impact of obesity on the conversion of immediate‐release tacrolimus to extended‐release tacrolimus in kidney transplant recipients
Authors: Newman Jessica , Patel Neha , Patel Shikha , Sprague Taylor , Bartlett Felicia , Rao Nikhil , Andrade Erika , Rohan Vinayak , DuBay Derek , Casey Michael J. , Taber David 
Published: October 2023

AbstractOutcomes analyzing conversion from IR‐tacrolimus (IR) to LCP‐tacrolimus (LCP) in obesity are limited. This was a retrospective longitudinal cohort study of patients converted from IR to LCP from June 2019 to October 2020. Primary outcomes were conversion ratios for weight‐based dose at a steady‐state therapeutic level and identification of appropriate dosing weight. Other outcomes included tacrolimus coefficient of variation (CV), time in therapeutic range (TITR), adverse events, infections, donor specific antibodies (DSAs), and acute rejection. A total of 292 patients were included; 156 and 136 patients with a BMI < 30 and BMI ≥ 30 kg/m2, respectively. Baseline characteristics were similar, except for pancreas transplant, diabetes, and HLA mismatch. IR to LCP conversion ratio ranged from .73 to .79. Mean LCP dose was similar (.08 vs. .07 mg/kg/day for BMI < 30 and BMI ≥ 30 kg/m2, respectively); there was a significant difference in IR and LCP mg/kg dosing at steady state with TBW (.11 mg/kg vs.09 mg/kg and .08 mg/kg vs. .06 mg/kg, respectively). The most appropriate dosing weight was adjusted body weight (AdjBW), consistent across IR and LCP steady‐state doses, and might yield more accurate steady‐state dosing requirements. In multivariable modeling, BMI was a significant predictor of steady state mg/kg dosing at therapeutic goal for total body weight (TBW), but not ideal body weight (IBW) or AdjBW.
Bioequivalence study of dacomitinib and Vizimpro® in healthy Chinese volunteers under fasting and fed conditions: A randomized, open‐label, single‐dose, crossover trial
Authors: Yang Xiaojia , Li Jinfang , Zhang Taihui , Xia Qinping , Zhang Wei , Cui Yike , He Wen 
Published: October 2023

AbstractThis study aimed to evaluate the bioequivalence between test tablet dacomitinib and reference product Vizimpro® under fasting and fed conditions and assess their pharmacokinetic (PK) and safety profiles for gaining marketing approval of the new generic drug. A single‐center, randomized, open‐label, single‐dose, two‐treatment, two‐period, crossover bioequivalence study was conducted in healthy Chinese subjects. Eligible healthy subjects randomly received a single 45 mg dose of test or reference formulations with an administration sequence of test tablet (T), reference tablet (R), or (RT), under both fasting and fed conditions, and each single administration was followed by a 21‐day washout period. Plasma concentrations and corresponding non‐compartmental PK parameters of dacomitinib were determined. The 90% confidence intervals of the geometric mean ratio (GMR) (test/reference) for Cmax, AUC0–t, and AUC0–∞, respectively, were 97.75%–119.99%, 101.00%–115.09%, and 100.27%–113.90% under fasting conditions and 95.20%–104.94%, 97.24%–102.23%, and 97.27%–101.88% under fed conditions, which were within the limits of 80%–125%. Under fasting and fed conditions, the PK characteristics of the test dacomitinib tablet and reference Vizimpro® were comparable; the two formulations of dacomitinib were demonstrated to be bioequivalent and well‐tolerated in healthy Chinese volunteers.