bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation, characterization, and in vitro biological evaluation of salicylic acid‐modified polyphenylene sulfide/quartz fiber/hydroxyapatite composite with high mechanical property for bone replacement
Authors: Cai Shijie , Yan Dawei , Chen Xiaolu , Yang Hulin , Chen Chaobi , Li Xiaodan , Yan Yonggang , Ren Haohao 
Published: November 2023

AbstractThe surface inertness of pure polyphenylene sulfide (PPS) limits its application in orthopedic implant materials. On that basis, modified PPS containing hydroxyl and carboxyl groups, that is, SAPPS was synthesized by nucleophilic substitution of dihalide monomers and sodium sulfide under high pressure. And consequently, a kind of ternary composite consisting of polyphenylene sulfide salicylate/quartz fiber/hydroxyapatite (SAPPS/QF/HA) was developed. The structure, composition, cross section morphology, degradation behavior, mechanical property, and biological property of all the composites were characterized by Fourier transform infrared spectroscopy, x‐ray diffraction, differential scanning calorimetry, thermogravimetric analyzer, scanning electron microscope, energy dispersive spectrometer, and in vitro cytocompatibility tests. The composites exhibited good thermal property, which achieved a high melting point (277.8°C) and decomposition temperature (493.9–502.7°C at 5% weight loss). When the mass fraction of 20 wt% QF and 20 wt% HA was added in the pure SAPPS, the bending yield strength and bending modulus of the composite (SAPPS/20QF/20HA) were 177.4 MPa and 8.03 GPa, respectively, which increased by 61.6% and 158.2% compared with that of the pure SAPPS. Observing the considerable proliferation and adhesion of mouse bone marrow mesenchymal stem cells (mBMSCs) in the experiment, we demonstrated that the SAPPS and its composites were non‐toxic, and the SAPPS/QF/20HA composites had the most prominent effect in promoting the proliferation and adhesion of mBMSCs.Highlights
Salicylic acid‐modified polyphenylene sulfide was studied as a biomaterial.
The composite material has mechanics matching with human cortical bone.
Cell experiments showed that all materials were nontoxic.
An Analysis of Direct and Indirect Costs in Hidradenitis Suppurativa
Authors: Howard-James Claudine , Tobin Anne-Marie 
Published: November 2023

Abstract

Background
Hidradenitis Suppurativa (HS) is a chronic inflammatory skin condition with recurrent nodules and abscesses that culminate in purulent discharge and scarring. It has significant physical, psychological and financial impact.

Objectives
This study plans to analyse patient costs associated with HS. Direct costs include prescription items. Indirect or out-of-pocket costs include dressings, analgesia, and healthcare-related travel costs. This study will also assess disease impact on quality-of-life (QOL).

Methods
Patients with HS diagnosis attending dermatology OPD at our public tertiary centre were invited to participate. Ethical approval was secured, and informed consent was obtained. Participants completed an anonymous survey which was analysed to identify costs associated with HS as well as demographics and QOL impact.

Results
A total of 25 patients completed the survey; median age was 29% and 80% were female. Median time from HS onset to diagnosis was 2 years, with 24% waiting &gt;10 years to be diagnosed. In the past 3 months, 20% spent &gt;€200 in both categories; prescription and non-prescription items. In the non-prescription category, 36% of patients reported expenditure &gt;€100 in the past 3 months. Dressings were the most common out-of-pocket expense (in 15/25 patients), followed by analgesia and protective clothing. Attendance at medical appointments cost 24% of patients €50–€200. Four participants reported difficulty accessing HS treatments due to associated costs. Mean number of absence days from work/education as result of HS was 8.7 in the past 3 months. Two patients reported being on disability allowance, and two on unemployment benefit as result of their skin disorder. In the QOL question; 96% reported disease impact on QOL, and 11 participants reported that it affected their life ‘very much’.

Conclusions
HS is a chronic inflammatory skin condition with significant financial burden alongside the well-analysed biopsychosocial disease impact. Financial burden can be divided into direct prescription costs and indirect costs such as non-prescription items, protective clothing and travel costs which we have explored in this study. Further research is needed in this area to identify and optimise both the financial and QOL implications of HS in acute flares and chronic disease management.
Kühlräume aus Sandwichelementen
Authors: Naujoks Bernd , Ardelmann Niklas 
Published: November 2023

AbstractKühlräume sind innenliegende bauliche Anlagen, die für die Lagerung von Lebensmitteln unverzichtbar sind. Für die Verteilzentren der Lebensmitteleinzelhändler wachsen die Anforderungen an große Flächen, sodass bereits Kühlräume in Stahlleichtbauweise mit Abmessungen von L × B × H = 50 m × 20 m × 16 m realisiert wurden, für die eine entsprechende Tragwerksplanung benötigt wird. Für den Bau dieser Kühlräume werden wegen ihrer hervorragenden Dämmeigenschaften überwiegend Sandwichelemente verwendet. Die räumliche Aussteifung kann direkt über die Decken‐ und Wandscheiben als Schubfelder erfolgen, wenn entsprechende konstruktive Regeln beachtet werden. Sofern die Wandelemente zur Abtragung der Deckenlasten auf die zusätzliche Normalkraftbeanspruchung nach Theorie II. Ordnung nachgewiesen werden, können Kühlräume aus Sandwichelementen ohne jegliche Unterkonstruktion hergestellt werden. Der Entwurf der neuen Norm prEN 1993‐7 „Bemessung und Konstruktion von Stahlbauten – Sandwichelemente“ enthält ein entsprechendes Bemessungsverfahren. Bauphysikalisch und statisch bewährte Detailausbildungen sowie Berechnungsbeispiele für Schubfelder und Druckstützen aus Sandwichelementen werden nachfolgend erläutert.
Experimentelle Untersuchungen an Verbindungen im Leichtbau als Basis für die Erdbebenbemessung
Authors: Wallner Anna , Ummenhofer Thomas 
Published: November 2023

AbstractTrapezprofile oder Sandwichelemente werden häufig als Gebäudehülle für Industrie‐ und Gewerbebauten verwendet. Das geringe Eigengewicht der Gebäudehülle in Metallleichtbauweise bietet im Erdbebenfall einen deutlichen Vorteil gegenüber anderen Bauweisen. Die duktilen Eigenschaften können gegenwärtig allerdings beim Erdbebennachweis nicht genutzt werden, da entsprechende Untersuchungen und Regelungen hinsichtlich der dynamischen Eigenschaften der Metallleichtbauelemente und deren Verbindungen fehlen. Es soll ermittelt werden, inwiefern die Dach‐ und Wandelemente, die zunächst nur eine raumabschließende Funktion haben, eine aussteifende Funktion als Schubfeld übernehmen und dadurch die Primärtragstruktur und die Aussteifungselemente entlasten. Dies ist vom Steifigkeitsverhältnis der genannten Bauteile abhängig. Um ein geeignetes Bemessungsverfahren für den Erdbebenfall zu entwickeln, werden aktuell im Rahmen eines Forschungsvorhabens der FOSTA Untersuchungen an Leichtbauverbindungen durchgeführt. Zunächst wird anhand statischer Versuche die Steifigkeit der Verbindungen ermittelt. Zur Erfassung der Eigenschaften unter Erdbebenbeanspruchung werden zyklische Versuche mit zunehmender Verformung durchgeführt. Auf Basis der Versuchsergebnisse sollen geeignete Ingenieurmodelle erarbeitet werden, die eine Aktivierung der Metallleichtbauelemente zur Energiedissipation bei Erdbebenbeanspruchung ermöglichen.
Standardized Schoeller diagrams—A Matlab plotting tool
Authors: Schäffer Rafael , Dietz Alexander 
Published: November 2023

AbstractA complete water analysis typically contains at least 65 chemical and physical parameters. This variety of parameters complicates temporal or spatial comparisons of different water samples. Hence, special hydrogeological diagrams, such as the Schoeller diagram, were developed to facilitate the evaluation and interpretation of analytical results of multiple samples. In conventional Schoeller diagrams, the concentrations of calcium, magnesium, sodium, chloride, sulfate, and bicarbonate/carbonate are plotted as points on logarithmic scales. Points of one analysis are connected to form characteristic signatures of each sample. Occasionally, resulting parallel signatures indicate a similar water genesis. Here, we present standardized Schoeller diagrams and introduce a practical Matlab tool for this purpose. Standardization means that the different logarithmic axes are shifted towards each other so that the signature of a selected sample becomes a horizontal line. This procedure greatly facilitates comparisons of water samples to the chosen standard and increases the informative value of the diagrams. However, manual implementations of standardizations are arduous and time-consuming, as a single calculation of the relocation of each axis is necessary. In addition, the calculations must be repeated if another sample is chosen as the standard. We developed a Matlab tool that allows the fast generation of standardized Schoeller diagrams with many options and implements user-specific preferences with just one command. Probably the most useful feature is that users can choose which parameters are displayed, opening up new areas of application for Schoeller diagrams.
Forecasting cryptocurrencies returns: Do macroeconomic and financial variables improve tail expectation predictions?
Authors: Lawuobahsumo Kokulo K. , Algieri Bernardina , Leccadito Arturo 
Published: November 2023

AbstractThis study aims to jointly predict conditional quantiles and tail expectations for the returns of the most popular cryptocurrencies (Bitcoin, Ethereum, Ripple, Dogecoin and Litecoin) using financial and macroeconomic indicators as explanatory variables. We adopt a Monotone Composite Quantile Regression Neural Network (MCQRNN) model to make one- and five-steps-ahead predictions of Value-at-Risk (VaR) and Expected Shortfall (ES) based on a rolling window and compare the performance of our model against the Historical simulation and the standard ARMA(1,1)-GARCH(1,1) model used as benchmarks. The superior set of models is then chosen by backtesting VaR and ES using a Model Confidence Set procedure. Our results show that the MCQRNN performs better than both benchmark models for jointly predicting VaR and ES when considering daily data. Models with the implied volatility index, treasury yield spread and inflation expectations sharpen the extreme return predictions. The results are consistent for the two risk measures at the 1% and 5% level both, in the case of a long and short position and for all cryptocurrencies.
Characterizing a collaboration by its communication structure
Authors: Wüthrich Adrian 
Published: November 2023

AbstractI present first results of my analysis of a collection of about 24,000 email messages from internal mailing lists of the ATLAS collaboration, at CERN, the particle physics laboratory, during the years 2010–2013. I represent the communication on these mailing lists as a network in which the members of the collaboration are connected if they reply to each other’s messages. Such a network allows me to characterize the collaboration from a bird’s eye view of its communication structure in epistemically relevant terms. I propose to interpret established measures such as the density of the network as indicators for the degree of “collaborativeness” of the collaboration and the presence of “communities” as a sign of cognitive division of labor. Similar methods have been used in philosophical and historical studies of collective knowledge generation but mostly at the level of information exchange, cooperation and competitionbetweenindividual researchers or small groups. The present article aims to take initial steps towards a transfer of these methods and bring them to bear on the processes of collaborationinsidea “collective author.”
Fuelling phytoremediation: gasoline degradation by green wall systems—a case study
Authors: Matheson Stephen , Fleck Robert , Lockwood Thomas , Gill Raissa L , Irga Peter J , Torpy Fraser R 
Published: November 2023

AbstractThe capacity for indoor plants including green wall systems to remove specific volatile organic compounds (VOCs) is well documented in the literature; however under realistic settings, indoor occupants are exposed to a complex mixture of harmful compounds sourced from various emission sources. Gasoline vapour is one of the key sources of these emissions, with several studies demonstrating that indoor occupants in areas surrounding gasoline stations or with residentially attached garages are exposed to far higher concentrations of harmful VOCs. Here we assess the potential of a commercial small passive green wall system, commercially named the ‘LivePicture Go’ from Ambius P/L, Australia, to drawdown VOCs that comprise gasoline vapour, including total VOC (TVOC) removal and specific removal of individual speciated VOCs over time. An 8-h TVOC removal efficiency of 42.45% was achieved, along with the complete removal of eicosane, 1,2,3-trimethyl-benzene, and hexadecane. Further, the green wall also effectively reduced concentrations of a range of harmful benzene derivatives and other VOCs. These results demonstrate the potential of botanical systems to simultaneously remove a wide variety of VOCs, although future research is needed to improve upon and ensure efficiency of these systems over time and within practical applications.
TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells
Authors: Huang Peiting , Zhang Zhanyu , Zhang Piao , Feng Jiezhu , Xie Jianwei , Zheng Yinjuan , Liang Xiaomei , Zhu Baoyu , Chen Zhenzhen , Feng Shujun , Wang Lijuan , Lu Jiahong , Liu Yawei , Zhang Yuhu 
Published: November 2023

AbstractMicroglia-mediated neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects in PD by regulating the phenotype of microglia. Recent studies suggest that TREM2 regulates high glucose-induced microglial inflammation through the NLRP3 signaling pathway. This study aimed to investigate the effect of TREM2 on NLRP3 inflammasome activation and neuroinflammation in PD. Mice were injected with AAV-TREM2-shRNA into both sides of the substantia nigra using a stereotactic injection method, followed by intraperitoneal injection of MPTP to establish chronic PD mouse model. Behavioral assessments including the pole test and rotarod test were conducted to evaluate the effects of TREM2 deficiency on MPTP-induced motor dysfunction. Immunohistochemistry of TREM2 and tyrosine hydroxylase (TH), immunohistochemistry and immunofluorescence Iba1, Western blot of NLRP3 inflammasome and its downstream inflammatory factors IL-1β and IL-18, and the key pyroptosis factors GSDMD and GSDMD-N were performed to explore the effect of TREM2 on NLRP3 inflammasome and neuroinflammation. In an in vitro experiment, lentivirus was used to interfere with the expression of TREM2 in BV2 microglia, and then lipopolysaccharide (LPS) and adenopterin nucleoside triphosphate (ATP) were used to stimulate inflammation to construct a cellular inflammation model. The expression differences of NLRP3 inflammasome and its components were detected by qPCR and Western blot. In vivo, TREM2 knockdown aggravated the loss of dopaminergic neuron and the decline of motor function. After TREM2 knockdown, the number of activated microglia was significantly increased, and the expression of cleaved caspase-1, NLRP3 inflammasome, IL-1β, GSDMD, and GSDMD-N was increased. In vitro, TREM2 knockdown aggravated the inflammatory response of BV2 cells stimulated by LPS and promoted the activation of NLRP3 inflammasome through the NF-κB pathway. In addition, TREM2 knockdown also promoted the expression of TLR4/MyD88, an upstream factor of the NF-κB pathway. Our vivo and vitro data showed that TREM2 knockdown promoted NLRP3 inflammasome activation and downstream inflammatory response, promoted pyroptosis, and aggravated dopaminergic neuron loss. TREM2 acts as an anti-inflammatory in PD through the TLR4/MyD88/NF-κB pathway, which extends previous findings and supports the notion that TREM2 ameliorates neuroinflammation in PD.
How Can Digital Storytelling Open Up Spaces for Activist Citizenship Where Young Children Create Stories of Hope and Resilience Across the World?
Authors: Macleroy Vicky , Chung Yu-chiao 
Published: November 2023

AbstractThis article examines how 8-year-old children in a primary school in England develop new understandings of hardship and survival through the process of digital storytelling. The research presented here is part of a larger global literacy ‘Critical Connections Multilingual Digital Storytelling Project’ (2012-ongoing) working across 15 countries (Algeria, Australia, Cyprus, Egypt, England, Germany, India, Italy, Luxembourg, Malaysia, Palestine, Switzerland, Taiwan, Turkey, U.S.A.) in over 36 languages. We build on critical literacy research which argues that in creating texts, such as digital stories, with an ethic of social justice, children have to navigate tensions existing within cultures, languages, and communities. In our research, we look at what happens when children create their own collaborative digital story, interrogating these tensions surrounding ideas and realities of social justice, and decide how to represent their lives and the lives of others. We analyze the filmmaking process and how a class of 8-year-old children create a digital story, A Reflection on Water, for the project. As part of the process of creating their digital story, these children walk around their school playground carrying heavy buckets of water, raise money for Water Aid, create a website, and want children across the world to get clean water. These young children become part of a wider digital storytelling community at a global film festival, and we examine their reflections on the digital story, From my Window- De ma Fenêtre, created by older 10-year-old children in their school. A Ukrainian child joined this class during the project and their digital story shifted to incorporate their collective response to the Ukrainian crisis. In conclusion, we return to the Critical Connections Pedagogical Model and demonstrate collaborative filmmaking can open up spaces for activist citizenship with young children, and stories of hope and resilience.
Fabricating modified carbon of oak fruit for adsorption of fluoride and nitrate from aqueous media: isotherm and kinetic models
Authors: Ramezani Ali , Lorestani Bahareh , Sobhanardakani Soheil , Cheraghi Mehrdad , Nourmoradi Heshmatollah 
Published: November 2023

AbstractFluoride and nitrate are one of the developed compounds that can enter water resources in different ways. The present research examines the effectiveness of activated carbon made from oak fruit to remove fluoride and nitrate from water, and then the as-synthesized adsorbent is functionalized using ammonium chloride species. The results showed that activated carbon-containing NH4Cl had the highest adsorption capacity for fluoride and nitrate pollutant. The maximum absorbing capacity is 26.00 mg/g for fluoride and 26.53 mg/g for nitrate. The results of the reaction kinetics and adsorption isotherms showed that the pseudo-second-order kinetics and Freundlich isotherm fit the data from this study better than other experimental models. Eventually, recycling the adsorbent for seven cycles to adsorb the pollutant showed no remarkable activity loss. Until now, most absorption methods have been performed to remove the pollutant concentration of 30 mg/l. In the current study, with the input pollutant concentration of 50 mg/l, it can be mentioned that the activated carbon modified from the oak fruit is a cheap, efficient, and effective adsorbent. It is considered available to remove fluoride from aqueous solutions.
Assessment of groundwater quality in terms of water quality index (WQI) and fluoride contamination of Nuapada District, Odisha, India
Authors: Swain Pratap Kumar , Biswal Trinath 
Published: November 2023

AbstractThe physico-chemical parameters and WQI of ground water in all five blocks of district Nuapada are calculated by taking ten samples from each block in the month of October 2019. The correlation study between different physicochemical parameters shows significant negative relationships. The WQI of ground water on Boden block is 472.1, Kharial is 366.7, Sinapali block is 319.82, Komana block is 344.1, and Nuapada block is 225.65. Hence the ground water of all these blocks is E-class and not fit for human use. Among all these blocks, the Boden block is highly polluted. The mean value of fluoride in the Boden block is 6.17 mg/l, the Kharial block is 4.79 mg/l, the Sinapali block is 3.93 mg/l, the Komana block is 4.47 mg/l, and the Nuapada block is 2.86 mg/l. Hence, the present study reveals that the groundwater quality of different regions of the district Nuapada is heavily polluted and not suitable for drinking.
Inhibition of the glutamate-cysteine ligase catalytic subunit with buthionine sulfoximine enhances the cytotoxic effect of doxorubicin and cyclophosphamide in Burkitt lymphoma cells
Authors: Kazimierska Marta , Leśniewska Aleksandra , Bakker Anja , Diepstra Arjan , Kasprzyk Marta Elżbieta , Podralska Marta , Rassek Karolina , Kluiver Joost , van den Berg Anke , Rozwadowska Natalia , Dzikiewicz-Krawczyk Agnieszka 
Published: November 2023

AbstractBurkitt lymphoma (BL) is a highly aggressive lymphoma that mainly affects children and young adults. Chemotherapy is effective in young BL patients but the outcome in adults is less satisfactory. Therefore, there is a need to enhance the cytotoxic effect of drugs used in BL treatment. Glutathione (GSH) is an important antioxidant involved in processes such as regulation of oxidative stress and drug detoxification. Elevated GSH levels have been observed in many cancers and were associated with chemoresistance. We previously identified GCLC, encoding an enzyme involved in GSH biosynthesis, as an essential gene in BL. We now confirm that knockout of GCLC decreases viability of BL cells and that the GCLC protein is overexpressed in BL tissues. Moreover, we demonstrate that buthionine sulfoximine (BSO), a known inhibitor of GCLC, decreases growth of BL cells but does not affect control B cells. Furthermore, we show for the first time that BSO enhances the cytotoxicity of compounds commonly used in BL treatment, doxorubicin, and cyclophosphamide. Given the fact that BSO itself was not toxic to control cells and well-tolerated in clinical trials, combination of chemotherapy with BSO may allow reduction of the doses of cytotoxic drugs required to obtain effective responses in BL patients.