bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect Of Using SDKI And Wilkinson Book On The Accuracy Level Of Nursing Diagnosis by Poltekkes Palu Nursing Student
Authors: Hasan Sri Musriniawati , Mulyanto Atim 
Published: January 2024

Nursing diagnosis is a clinical judgement made by a nurse about patients’ respond towards their health condition. Data shows that 40% of nursing students don’t have enough skills to make precise nursing diagnose. The aim of this study is to assess the effect of the use of the SDKI book and Wilkinson nursing diagnosis 10th edition book on the nursing students’ accuracy in making nursing diagnoses. We use a quasi-experimental method with the second grade of Poltekkes Palu nursing students as the subject of this study (n=93). The subjects were then divided into 3 groups. The first group was given the SDKI book as the intervention, the second group with the Wilkinson, and the third group was the control. Data were collected and analyzed with one-sample t-test (α<0,05) to assess the students’ nursing diagnose accuracy before and after interventions. Results show that there is a statistically significant increment before and after intervention in the Wilkinson group (α = 0,018). While there are no significant increments both in the SDKI group (9,2 point increment), Wilkinson group (42 point increment), and in the control group (10,8 point of increment). In conclusion, the use of Wilkinson nursing diagnoses 10th edition affects the increment of Poltekkes Palu students’ nursing diagnosis accuracy.
The Effect of Diabetic Foot Exercises on Ankle Brachial Index Values and the Degree of Diabetic Foot Risk in Diabetes Melitus Patients
Authors: Nurmalisa Baiq Emy , Supirno Supirno 
Published: January 2024

Background: The prevalence of Diabetic Foot Ulcers (DFU) in diabetics is 4-10% where this condition more often affects the elderly. DFU is a serious marker of a disease that if optimal prevention is not carried out from the start, the wound deteriorates rapidly, and the worst is amputation. Diabetic foot exercises are used as leg exercises and are beneficial in reducing pain, reducing nerve damage, controlling blood sugar and increasing blood circulation in the feet. The purpose of this study was to analyze the effect of diabetic foot exercise on the degree of risk of diabetic foot ulcers and the Ankle brachial index value in Diabetes Mellitus patients in the Work Area of the Mamboro Health Center. Methods: This type of research is quasi-experimental with a one group pretest posttest design. The sample is 16 people. The instruments used were a monofilament test, sphygmomanometer, stethoscope, and an instrument for assessing the risk of diabetic foot. Data analysis used is paired t test and Wilcoxon test. Results The results showed that diabetic foot exercise had an effect on changes in the value of blood circulation (ABI) with a p value (0.000) and a score of degrees of risk of diabetic foot with a p value (0.001). Conclusion of this study is that diabetic foot exercise has a statistical effect on both the ABI value and the diabetic foot degree score. Suggestions from this study are that nurses more often conduct DM foot exercise education in an effort to prevent DFU
Efektifitas Pemberian Jus Mentimun terhadap Perubahan Tekanan Darah pada Pasien Hipertensi di Desa Padang Wilayah Kerja Puskesmas Kintom
Authors: Arifuddin Arifuddin 
Published: January 2024

Latar belakang Prevalensi penderita hipertensi di Kabupaten Luwuk terus meningkat dimana tahun 2019 sebanyak 13,47% dan pada tahun 2020 sebesar 26%. Tujuan penelitian ini mengetahui efektivitas jus mentimun terhadap perubahan tekanan darah pada pasien hipertensi di Desa Padang wilayah kerja Puskesmas Kintom. Metode Jenis penelitian adalah Quasy experiment design (pretest – posttest with control grup).Variabel independen dalam penelitian ini adalah terapi jus mentimun dan variabel dependen dalam penelitian ini adalah tekanan darah pada penderita hipertensi. Sampel dalam penelitian ini berjumlah 38 orang dibagi menjadi dua kelompok, kelompok perlakuan 19 orang dan kelompok kontrol 19 orang. Analisa data menggunakan uji Paired t-test. Hasil rata-rata tekanan darah sistolik dan diastolik pada kelompok perlakuan sebelum diberikan terapi jus mentimun adalah 165,26/97,37 mmHg dan rata-rata tekanan darah sistolik dan diastolik sesudah diberikan terapi jus mentimun adalah 138,68/89,21 mmHg. Pada kelompok kontrol diperoleh rata-rata 161,0/99,4 mmHg tekanan darah sistolik dan diastolik pada awal dan 159,4/100,5 mmHg, tekanan darah sistolik dan diastolik pada akhir. Penelitian ini menunjukkan pada kelompok perlakuan yang diberikan jus mentimun terbukti berpengaruh terhadap perubahan tekanan darah pada pasien hipertensi, dengan p- value = (0,000 < 0,05). Kesimpulan Pemberian jus mentimun terbukti efektif memberikan perubahan tekanan darah pada pasien hipertensi. pengobatan secara konvensional atau secara medis, jus mentimun bisa dijadikan terapi komplementer untuk menurunkan tekanan darah.
Antimicrobial and wound healing potential of naphthoquinones encapsulated in nanochitosan
Authors: Freitas Cyntia Silva , Pereira Patricia Ribeiro , Cardoso Raiane Vieira , Pauli Fernanda Petzold , Ribeiro Ruan Carlos Busquet , Da Silva Fernando De Carvalho , Ferreira Vitor Francisco , Paschoalin Vania Margaret Flosi 
Published: January 2024

Introduction: The use of chitosan in pharmaceutical formulations is an advantageous approach due to this compound intrinsic biodegradability and biocompatibility, as well as ready availability and low polymer cost.Methods: Herein, the naphthoquinones 3- chloromethylene-menadione (NQ1) and 2,3-dichloro-1,4-naphthoquinone (NQ2) were nanoencapsulated into chitosan (CNP) by the ionotropic gelatinization technique and characterized by DLS, FTIR, SEM, TGA and DSC, and their release profiles evaluated. The antimicrobial and wound healing activities were investigated.Results and Discussion: Homogeneous chitosan nanocapsulses of about 193 nm and Z potential ranging from +30.6 to +33.1 mV loaded with NQ1 (CNP-NQ1) or NQ2 (CNPQNQ2). With nanoencapsulation efficiencies of ≥ 96%, the solubility of naphthoquinones in aqueous environments was improved, making them suitable for biological system applications. The encapsulated naphthoquinones displayed a controlled release of approximately 80% for CNP-NQ1 and 90% for CNP-NQ2 over an 8 h period at 36°C. Both CNP-NQ1 and CNP-NQ2 retained the already established free naphthoquinone antimicrobial activity against two Staphylococcus aureus strains, Staphylococcus epidermidis, Streptococcus pyogenes and Pseudomonas aeruginosa. Although presenting low toxicity to healthy human cells, only CNP-NQ1 displayed therapeutic indices above 100 for S. aureus and S. epidermidis and above 27 for S. pyogenes and P. aeruginosa, allowing for safe use in human tissues. Furthermore, CNP-NQ1 did not impair the migration of human fibroblast cells in scratch assays, adding promising wound healing properties to this formulation. These findings emphasize that CNP-NQ1 may be useful in protecting injured skin tissue from bacterial contamination, avoiding skin infections not only by reducing bacterial loads but also by accelerating the healing process until complete dermal tissue recovery.
Cytocompatible and osteoconductive silicon oxycarbide glass scaffolds 3D printed by DLP: a potential material for bone tissue regeneration
Authors: Carnieri Matheus Versão , Garcia Daniele de Freitas , Voltolini Rafael , Volpato Neri , Mafra Marcio , Bernardelli Euclides Alexandre , Stimamiglio Marco Augusto , Rebelatto Carmen Kuniyoshi , Correa Alejandro , Berti Lucas Freitas , Marcon Bruna Hilzendeger 
Published: January 2024

Bone lesions affect individuals of different age groups, compromising their daily activities and potentially leading to prolonged morbidity. Over the years, new compositions and manufacturing technologies were developed to offer customized solutions to replace injured tissue and stimulate tissue regeneration. This work used digital light processing (DPL) technology for three-dimensional (3D) printing of porous structures using pre-ceramic polymer, followed by pyrolysis to obtain SiOC vitreous scaffolds. The SiOC scaffolds produced had an amorphous structure (compatible with glass) with an average porosity of 72.69% ± 0.99, an average hardness of 935.1 ± 71.0 HV, and an average maximum flexural stress of 7.8 ± 1.0 MPa, similar to cancellous bone tissue. The scaffolds were not cytotoxic and allowed adult stem cell adhesion, growth, and expansion. After treatment with osteoinductive medium, adult stem cells in the SiOC scaffolds differentiated to osteoblasts, assuming a tissue-like structure, with organization in multiple layers and production of a dense fibrous matrix rich in hydroxyapatite. The in vitro analyses supported the hypothesis that the SiOC scaffolds produced in this work were suitable for use as a bone substitute for treating critically sized lesions, with the potential to stimulate the gradual process of regeneration of the native tissue. The data obtained stimulate the continuity of studies with the SiOC scaffolds developed in this work, paving the way for evaluating safety and biological activity in vivo.
Influence of Trichosanthes pericarpium extract on improving microcirculation and outcomes of patients with acute myocardial infarction after percutaneous coronary intervention
Authors: Xi Peng , Xie Yuan , Huang Feifei , Liu Yang , Xu Jiahong 
Published: January 2024

BackgroundMicrocirculatory dysfunction is an independent risk factor for a poor prognosis after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Trichosanthes pericarpium is a well-known Chinese traditional herb described with the effect of activating blood circulation to dissipate blood stasis and improve blood circulation. However, its effects on microcirculation in patients with AMI after primary PCI remain unknown. This study aimed to investigate the effect of Trichosanthes pericarpium extract (TPE) on improving microcirculation and outcomes in patients with AMI after PCI.MethodsThis study included 155 patients with a history of emergency PCI treatment. In this cohort, 31 patients received a course of TPE, defined as intravenous TPE infusion (12 ml TPE dissolved in 250 ml 5% Glucose Injection) once daily for 7 days on the background of standard treatment after PCI; 124 who did not receive TPE were regarded as the control group and received standard treatment after PCI. The corrected thrombolysis in myocardial infarction frame count (CTFC) and index of microcirculatory resistance (IMR) were used to evaluate myocardial microcirculation. Cardiac function was measured by echocardiography during hospitalization and follow-up. Major adverse cardiac events (MACEs) were recorded for prognostic analysis.ResultsAt the 6-month follow-up, AMI patients who received TPE after primary PCI had significantly lower levels of CTCF (24.27 ± 2.40 vs. 21.88 ± 1.92, P &lt; 0.001) and IMR (20.02 ± 2.20 vs. 17.80 ± 2.11, P &lt; 0.001) than patients in the control group. Left ventricular ejection fraction and left ventricular internal dimension at systolic at 6-month follow-up in the TPE group significantly improved than in the control group (56.6 ± 4.5 vs. 62.1 ± 3.5, P &lt; 0.001; 32.5 ± 1.5 vs. 30.2 ± 1.8, P &lt; 0.001). Kaplan-Meier curve analysis indicated that patients with AMI who received TPE had significantly lower rates of MACEs than the control group at 6-month follow-up (P = 0.042).ConclusionIn the context of standard treatment, Trichosanthes pericarpium further improved coronary microcirculation, increased cardiac function, and reduced short-term MACEs rate. Our data suggest that TPE could be used in combination therapy for patients with AMI after primary PCI.
Mechanism and genesis of Sanmen Bay as a sink of Holocene Yangtze River sediment, Zhejiang Province, China
Authors: Qiu Jiandong , Jiang Shenghui , Wang Jianqiang , Feng Jing , Chen Junbing , Dong Chao , Jiang Yunshui , Zhang Daolai 
Published: January 2024

Introduction: The Holocene mud deposits that extend from the Yangtze River mouth to the Taiwan Strait along the Zhejiang–Fujian coast, East China Sea (ECS), have attracted considerable research attention. However, there is a lack of consensus regarding the redistribution flux of Yangtze River sediment after it enters the sea. There are many bays along the Zhejiang and Fujian coasts, but their role in the source–sink process of Yangtze River sediment is not well-documented owing to limited data.Methods: In this study, data from shallow seismic profiles, core samples, and surface sediment samples were analysed to assess the role of Sanmen Bay, the second largest bay in Zhejiang Province, in the source–sink process of Yangtze River sediments.Results: The results showed that Sanmen Bay is an important sink for Yangtze River sediments. The characteristics of the clay minerals indicate that the fine-grained sediments in Sanmen Bay are mainly derived from Yangtze River sediments. The thickness of Holocene deposits in Sanmen Bay ranges from 8.2 to 32.0 m, with an average of 23.4 m and a total sediment volume of 5.06 × 104 Mt, accounting for 1% of Yangtze River sediment in this time period. The Bayesian age-depth model based on borehole accelerator mass spectrometry (AMS) 14C dating shows that a high sedimentation rate occurred in the early and late Holocene but decreased significantly in the mid-Holocene, which is similar to that of the inner shelf of the East China Sea (ECS).Conclusion: The variation in the Holocene sedimentation rate in Sanmen Bay is related to the southward transport process and mechanism of Yangtze River sediments. The results of this study provide a basis for understanding the source–sink process of sediment in large rivers.
Lessons learned from a peer-supported diabetes education program in two dissimilar Mayan communities
Authors: Castillo-Hernandez Karen G. , Espinosa Alan , Molina-Segui Fernanda , Ayuso-Peraza Giselle , Mena-Macossay Leticia , Mendez-Dominguez Nina , Bastarrachea Raúl A. , Laviada-Molina Hugo 
Published: January 2024

BackgroundA steady rise in type 2 diabetes (T2D) in Mexico over the last 30 years has led to 11.5 million Mexicans being affected by this condition. There is an urgent need to develop interventions to prevent complications of T2D. Diabetes self-management education is the cornerstone of promoting self-care. Among all educational strategies, peer support has shown to be an effective method to encourage ongoing self-management. However, customization of interventions for distinct communities is imperative, as failure to do so can hinder the intervention’s effectiveness.MethodsWe implemented a two-year prospective randomized controlled community-based trial in Conkal, a Mayan community from Yucatan, Mexico. The intervention consisted of receiving either a culturally sensitive peer support on top of a diabetes self-management education group (PLG); or a diabetes self-management education group only (EOG; control group). The primary outcome was changes in glycated hemoglobin, while secondary outcomes encompassed changes in systolic and diastolic blood pressure, body mass index, and diabetes self-care practices. Data collection was performed at baseline and every four months during the study period.DiscussionOur experiences have highlighted the significance of peer-leader support in cultivating diabetes self-care skills, particularly within smaller, underserved communities characterized by strong social and cultural ties. However, when applied in larger or suburban settings, selecting peer leaders should be meticulous, considering sectorization within specific neighborhoods to foster a sense of belonging and familiarity among natural community clusters. In larger settlemnts, factors such as transportation challenges, time limitations, caregiving obligations, limited venue access, and changes in session locations can drive program discontinuation. Additionally, individuals with lower educational attainment are more susceptible to abandonment. Notably, those with lower education, uncontrolled diabetes, and extended diabetes duration exhibit a greater potential for improving glycemic control than their counterparts.Clinical registrationhttps://www.isrctn.com/ISRCTN96897082.
Prospective application of a prediction model for lateral lymph node metastasis in papillary thyroid cancer patients with central lymph node metastasis
Authors: Ma Yunhan , Li Yi , Zheng Luming , He Qingqing 
Published: January 2024

ObjectiveThis study aimed to develop and apply a prediction model to estimate the probability of lateral lymph node metastasis (LLNM) in patients with cN0 unilateral papillary thyroid carcinoma (PTC) with central lymph node metastasis (CLNM).SettingAll study data were collected from a single tertiary hospital.MethodsUnivariable and multivariable logistic regression analyses were used to explore independent predictors of LLNM in the derivation and internal validation cohorts, which were used to construct and validate a nomogram. Another 96 patients were included prospectively to evaluate the efficacy of this nomogram.ResultsMaximum tumor diameter greater than 1.0 cm (OR, 2.712; 95% CI, 1.412–5.210), multifocality (OR, 2.758; 95% CI, 1.120–6.789), the number of CLNM ≥3 (OR, 2.579; 95% CI, 1.315–5.789), CLNM ratio ≥0.297 (OR, 2.905; 95% CI, 1.396–6.043), and tumors located in the upper portion (OR 2.846, 95% CI 1.151–7.039) were independent predictors associated with LLNM. The prediction model showed excellent discrimination with an AUC of 0.731 (95% CI, 0.635–0.827). Novel risk stratification for LLNM was constructed based on this nomogram. In the prospective cohort, we stratified these patients into three risk subgroups: low-, moderate-, and high-risk subgroups and we found that the probability of LLNM was positively correlated with the total points from the nomogram.ConclusionThis nomogram was applied in prospective clinical practice and distinguished PTC patients with a genuinely high risk of LLNM. Surgeons can use our nomogram to tailor the surgical plan and to credibly determine further postoperative therapy.
Limosilactobacillus reuteri DSM 17938 and ATCC PTA 6475 for the treatment of moderate to severe irritable bowel syndrome in adults: a randomized controlled trial
Authors: Cruchet Silvia , Hirsch Sandra , Villa-López Diana , Moreno-Portillo Mucio , Palomo Juan C. , Abreu-Abreu Ana T. , Abdo-Francis Juan M. , Jiménez-Gutiérrez Carlos , Rojano Martin , López-Velázquez Gabriel , Gutiérrez-Castrellón Pedro 
Published: January 2024

BackgroundIrritable bowel syndrome (IBS) is a common functional gastrointestinal disorder in adults. Systematic reviews with meta-analyses have demonstrated the efficacy and safety of probiotics in improving symptoms of IBS.AimThe aim of the study was to demonstrate the efficacy and safety of Limosilactobacillus reuteri (L. reuteri) DSM 17938 combined with L. reuteri ATCC PTA 6475 regarding improving the symptoms associated with IBS in adults.MethodsA randomized, double-blind, placebo-controlled clinical trial was conducted in 140 adults aged 18 years to 65 years with a diagnosis of IBS (based on the Rome IV criteria). After 2 weeks of washout, subjects were randomized to receive either 2 × 108 colony-forming units (CFUs) of L. reuteri DSM 17938 combined with L. reuteri ATCC PTA 6475 plus standard of care or placebo plus standard of care for 14 weeks, followed by a post-intervention period of 2 additional weeks. Changes in gastrointestinal symptoms (as measured with the GSRS-IBS), stool pattern (as measured with the Bristol scale), quality of life, depression and anxiety, frequency of adverse events, and fecal calprotectin concentrations were evaluated.ResultsIn total, 70 subjects were allocated to receive L. reuteri and 70 were allocated to receive placebo. During the pre-randomization phase, no differences were observed between the groups in terms of IBS-associated symptoms and stool consistency. Starting at week 6 of the intervention, subjects in group L. reuteri showed a significant improvement in IBS-associated symptoms (p &lt; 0.01). A significant improvement was also observed in fecal calprotectin concentration in the L. reuteri group at the end of interventions (30.2 ± 11.8 mg/g of stool in the L. reuteri group and 41.6 mg/g ± 10.7 mg/g in the placebo group; p = 0.019). The frequency of adverse events was similar between groups.ConclusionsA twice-a-day intervention for 14 weeks is safe and effective, reduces the symptoms associated with IBS in adults aged 18 years to 65 years, improves stool consistency, and reduces symptoms associated with anxiety after 6 weeks.
Humoral and cellular immune responses after COVID-19 vaccination of lung transplant recipients and patients on the waiting list: a 6-month follow-up
Authors: Hoek Rogier A. S. , Liu Siqi , GeurtsvanKessel Corine H. , Verschuuren Erik A. M. , Vonk Judith M. , Hellemons Merel E. , Kool Mirjam , Wijbenga Nynke , Bogers Susanne , Scherbeijn Sandra , Rugebregt Sharona , van Gemert Johanna P. , Steenhuis Willie N. , Niesters Hubert G. M. , van Baarle Debbie , de Vries Rory D. , Van Leer Buter Coretta 
Published: January 2024

BackgroundData on cellular response and the decay of antibodies and T cells in time are scarce in lung transplant recipients (LTRs). Additionally, the development and durability of humoral and cellular immune responses have not been investigated in patients on the waitlist for lung transplantation (WLs). Here, we report our 6-month follow-up of humoral and cellular immune responses of LTRs and WLs, compared with controls.MethodsHumoral responses to two doses of the mRNA-1273 vaccination were assessed by determining spike (S)-specific IgG antibodies and neutralizing antibodies. Cellular responses were investigated by interferon gamma (IFN-γ) release assay (IGRA) and IFN-γ ELISpot assay at 28 days and 6 months after the second vaccination.ResultsIn LTRs, the level of antibodies and T-cell responses was significantly lower at 28 days after the second vaccination. Also, WLs had lower antibody titers and lower T-cell responses compared with controls. Six months after the second vaccination, all groups showed a decrease in antibody titers and T-cell responses. In WLs, the rate of decline of neutralizing antibodies and T-cell responses was significantly higher than in controls.ConclusionOur results show that humoral and cellular responses in LTRs, if they develop, decrease at rates comparable with controls. In contrast, the inferior cellular responses and the rapid decay of both humoral and cellular responses in the WL groups imply that WLs may not be protected adequately by two vaccinations and repeat boostering may be necessary to induce protection that lasts beyond the months immediately post-transplantation.