bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico Evaluation of the Feasibility of Magnolia officinalis Electron-shuttling Compounds as Parkinson’s Disease Remedy
Authors: Rivera Zaina Allyson , Tayo Lemmuel , Chen Bor-Yann , Tsai Po-Wei 
Published: October 2023

Background:
Parkinson’s Disease is one of the leading neurodegenerative disorders in the
world. Currently, there is still no treatment that could completely cure the disease. Traditional Chinese
Medicine has been a source for drug candidates, and many studies have elucidated its pharmacokinetic
capabilities. Previous studies showed that Magnolia officinalis has anti-inflammatory, antioxidant, and
bioenergy generation activities. Furthermore, the electron-shuttling and bioenergy-stimulating capabilities of herbal and brain disorder medicines have been linked to their effectiveness as a remedy.

Objective:
This preliminary study aims to evaluate the electron-shuttling compounds of Magnolia
officinalis (i.e., acteoside, isoquercitrin, magnatriol B, obovatol, quercitrin, randaiol, and rutin) as
potential drug candidates for Parkinson’s Disease.

Methods:
The seven electron-shuttling compounds were individually docked to the five Parkinson’s
Disease-related proteins, namely aromatic L-amino acid decarboxylase, α-synuclein, monoamine
oxidase B, catechol-o-methyltransferase, and A2A adenosine receptor, using LibDock. ADMET predictions were also made to screen the compounds further.

Results:
Molecular docking results showed that all compounds have relatively high LibDock scores
against the proteins, with acteoside, isoquercitrin, and rutin having the highest scores. However,
considering the ADMET results, only magnatriol B, obovatol, and randaiol had optimal properties as
candidates for neurodegenerative drugs.

Conclusion:
The electron-shuttling compounds of M. officinalis, magnatriol B, obovatol, and randaiol, have the potential to be a remedy for Parkinson’s Disease due to their high probability of binding to the proteins.
Fish Allergy and Related Conditions in Children: A Review
Authors: Giannetti Arianna , Bettini Irene , Alfieri Eleonora , De Bona Amina , Giannì Giuliana , Ricci Giampaolo , Caffarelli Carlo 
Published: October 2023

Abstract:
Fish allergy is the important food allergies in childhood, often persisting into adulthood.
It can cause severe hypersensitivity reactions, including fatal anaphylaxis; furthermore,
avoiding-fish diet has negative nutritional and psychological effects. Recent research studies focus
on epitope structures and aim to develop sensitive and specific diagnostic tools, which have a better
correlation with clinical reactions. Protocols with hypoallergenic parvalbumin or other recombinant
antigens are also under study and will likely lead to new immunotherapy protocols.

:
IgE-mediated fish allergy differs substantially from other forms of immunological adverse reactions
to fish, such as Food Protein-Induced Enterocolitis Syndrome and eosinophilic esophagitis.
In addition, fish ingestion can cause non-immunological adverse reactions, such as in the case of
scombroid poisoning, anisakiasis and toxic poisoning.

:
This review aims to summarize the characteristics of the main immunological and non-immunological
fish reactions, analyzing the epidemiology, clinical manifestations, diagnosis and therapy,
with a particular focus on clinical management.
Acroparesthesias: An Overview
Authors: Slouma Maroua , Ben Dhia Siwar , Cheour Elhem , Gharsallah Imen 
Published: October 2023

Abstract::
Acroparesthesia is a symptom characterized by a subjective sensation, such as numbness,
tingling, prickling, and reduced sensation, affecting the extremities (fingers and toes). Despite
its frequency, data regarding its diagnostic approach and management are scarce. The etiological
diagnosis of acroparesthesia is sometimes challenging since it can be due to abnormality anywhere
along the sensory pathway from the peripheral nervous system to the cerebral cortex.

:
Acroparesthesia can reveal several diseases. It can be associated with rheumatic complaints such
as arthritis or myalgia.

:
Further cautions are required when paresthesia is acute (within days) in onset, rapidly progressive,
severe, asymmetric, proximal, multifocal, or associated with predominant motor signs (limb weakness)
or severe dysautonomia. Acroparesthesia may reveal Guillain-Barré syndrome or vasculitis,
requiring rapid management.

:
Acroparesthesia is a predominant symptom of polyneuropathy, typically distal and symmetric, often
due to diabetes. However, it can occur in other diseases such as vitamin B12 deficiency, monoclonal
gammopathy of undetermined significance, or Fabry’s disease. Mononeuropathy, mainly
carpal tunnel syndrome, remains the most common cause of acroparesthesia.

:
Ultrasonography contributes to the diagnosis of nerve entrapment neuropathy by showing nerve
enlargement, hypoechogenic nerve, and intraneural vascularity. Besides, it can reveal its cause,
such as space-occupying lesions, anatomical nerve variations, or anomalous muscle. Ultrasonography
is also helpful for entrapment neuropathy treatment, such as ultrasound-guided steroid injection
or carpal tunnel release.

:
The management of acroparesthesia depends on its causes.

:
This article aimed to review and summarize current knowledge on acroparesthesia and its causes.

:
We also propose an algorithm for the management of acroparesthesia.
The Possible Association of IL-6R Gene Polymorphisms in the
Development of Diabetic Nephropathy
Authors: Ebrat Ebrahim , Hejazian Seyyedeh Mina , Ahmadian Elham , Vahed Sepideh Zununi , Mobasseri Majid , Ardalan Mohammadreza 
Published: October 2023

Background:
Diabetic nephropathy (DN) is a common complication of type 2 diabetes (T2D). Chronic inflammation and a combination of environmental and genetic factors are involved in the pathogenesis and development of DN.

Objective:
This case-control study aimed to determine the relationship between rs7529229 and
rs2228145 polymorphisms of the IL-6R gene with the incidence of nephropathy among T2D patients

Methods:
Fifty-six diabetic patients with nephropathy and 57 T2D patients without nephropathy
were included based on inclusion criteria, along with 150 healthy individuals

Results:
The frequencies of AC and CC genotype distributions of the rs2228145 polymorphism
in DN patients were significantly higher than in healthy individuals (24.1 and 9.3% versus 10.7
and 6.7%, respectively, P= 0.02). Moreover, the frequency of allele C was higher in DN patients
compared to healthy controls (21.30% versus 12%, P=0.025). However, genotype distribution
and allele frequencies of the rs7529229 IL-6R polymorphism in DN patients were not statistically significant in comparison with diabetic patients and healthy individuals (P> 0.05).

Conclusion:
The results showed that the allele and genotype distribution frequencies of
rs2228145 IL-6R gene polymorphism in patients with DN were significantly higher than in
healthy individuals. Therefore, the presence of this polymorphism may be involved in the development of diabetic nephropathy in this population.
High-Altitude Pulmonary Edema Combined with Spontaneous
Pneumomediastinum: A Case Report
Authors: Li Wenzhe , Wang Yajing , Xu Li , Yuan Fang 
Published: October 2023

Background:
High-altitude pulmonary edema (HAPE) is a serious life-threatening disease that occurs after rapid ascent to high altitude; its main early-stage
presentations include fatigue, headache, low-grade fever, dyspnea, and cough. X-ray and computed tomography (CT) images show pulmonary
shadows and patches, which may be localized (initial right lung field predomination) or generalized to the bilateral lung base.

Case Presentation:
In this report, we present a case of a 25-year-old man diagnosed with HAPE combined with spontaneous pneumomediastinum. After a quick
descent and effective medical treatment, this patient made a full recovery. The case may provide helpful information for the prevention and
treatment of this disease since an increased number of people, especially young men, currently travel and work at high altitudes.

Conclusion:
After accurate clinical diagnosis with the help of CT or X-ray, immediate descent and appropriate oxygen supplementation are the most effective
treatments for HAPE at high altitude.
Exploring the Molecular Mechanism of Niuxi-Mugua Formula in Treating Coronavirus Disease 2019 via Network Pharmacology, Computational Biology, and Surface Plasmon Resonance Verification
Authors: Wang Wei , Cao Xu , Cao Yi-nan , Liu Lian-lian , Zhang Shu-ling , Qi Wen-ying , Zhang Jia-xin , Yang Xian-zhao , Li Xiao-ke , Zao Xiao-bin , Ye Yong-an 
Published: October 2023

Background:
In China, Niuxi-Mugua formula (NMF) has been widely used to prevent
and treat coronavirus disease 2019 (COVID-19). However, the mechanism of NMF for
treating COVID-19 is not yet fully understood.

Objective:
This study aimed to explore the potential mechanism of NMF for treating COVID-
19 by network pharmacology, computational biology, and surface plasmon resonance (SPR)
verification.

Materials and Methods:
The NMF-compound-target network was constructed to screen the key
compounds, and the Molecular Complex Detection (MCODE) tool was used to screen the preliminary
key genes. The overlapped genes (OGEs) and the preliminary key genes were further
analyzed by enrichment analysis. Then, the correlation analysis of immune signatures and the
preliminary key genes was performed. Molecular docking and molecular dynamic (MD) simulation
assays were applied to clarify the interactions between key compounds and key genes.
Moreover, the SPR interaction experiment was used for further affinity kinetic verification.

Results:
Lipid and atherosclerosis, TNF, IL-17, and NF-kappa B signaling pathways
were the main pathways of NMF in the treatment of COVID-19. There was a positive
correlation between almost the majority of immune signatures and all preliminary key
genes. The key compounds and the key genes were screened out, and they were involved
in the main pathways of NMF for treating COVID-19. Moreover, the binding affinities of
most key compounds binding to key genes were good, and IL1B-Quercetin had the best
binding stability. SPR analysis further demonstrated that IL1B-Quercetin showed good binding
affinity.

Conclusion:
Our findings provided theoretical grounds for NMF in the treatment of COVID-
19.
RHBDD1 Promotes the Growth and Stemness Characteristics of Gastric
Cancer Cells by Activating Wnt/β-catenin Signaling Pathway
Authors: Yang Yingxue , Yuan Yuan , Xia Boning 
Published: October 2023

Backgrounds:
Gastric cancer (GC) is threatening public health, with at least one million
new cases reported each year. Rhomboid domain-containing protein 1 (RHBDD1) has been
identified to regulate the proliferation, migration, and metastasis of cancer cells. However, the
role of RHBDD1 in GC has not been elucidated.

Objects:
This study aimed to investigate the role of RHBDD1 on the growth, metastasis, and stemness
characteristics of GC.

Methods:
RHBDD1 expression was analyzed from the TCGA databank. qRT-PCR was conducted
to evaluate the transcription level of RHBDD1. Western blots were used to evaluate the protein
expression of RHBDD1, CD133, CD44, Nanog, β-catenin and c-myc. Colony formation assay
and transwell assay were conducted to evaluate the growth and metastasis of NCI-N87 cells, respectively.
Sphere-forming assay was performed to study the stemness characteristics. The nude
mice xenotransplantation model and immunohistochemistry (IHC) were performed to evaluate the
growth of GC in vivo.

Results:
RHBDD1 expression is elevated in GC cells and clinical tissues. RHBDD1 expression is
positively associated with cell proliferation and metastasis of GC cells. RHBDD1 knockdown suppresses
the expression of CD133, CD44 and Nanog and attenuates sphere-forming ability. RHBDD1
activates the Wnt/β-catenin pathway via promoting the expression of β-catenin / c-myc and inducing
β-catenin translocation into nuclear. RHBDD1 knockdown inhibits the growth of GC in
nude mice xenotransplantation model.

Conclusion:
RHBDD1 is highly expressed in GC, and its knockdown inhibits the growth, metastasis
and stemness characteristics of GC cells through activating the Wnt/β-catenin pathway,
suggesting that RHBDD1 has the potential to be a novel therapeutic target for GC treatment.
Artificial Intelligence in The Management of Neurodegenerative
Disorders
Authors: Dhankhar Sanchit , Mujwar Somdutt , Garg Nitika , Chauhan Samrat , Saini Monika , Sharma Prerna , Kumar Suresh , Kumar Sharma Satish , Kamal Mohammad Amjad , Rani Nidhi 
Published: October 2023

Abstract:
Neurodegenerative disorders are characterized by a gradual but irreversible loss of neurological
function. The ability to detect and treat these conditions successfully is crucial for ensuring
the best possible quality of life for people who suffer from them. The development of effective new
methods for managing and treating neurodegenerative illnesses has been made possible by recent
developments in computer technology. In this overview, we take a look at the prospects for applying
computational approaches, such as drug design, AI, ML, and DL, to the treatment of neurodegenerative
diseases. To review the current state of the field, this article discusses the potential of computational
methods for early disease detection, quantifying disease progression, and understanding the
underlying biological mechanisms of neurodegenerative diseases, as well as the challenges associated
with these approaches and potential future directions. Moreover, it delves into the creation of
computational models for the individualization of care for neurodegenerative diseases. The article
concludes with suggestions for future studies and clinical applications, highlighting the advantages
and disadvantages of using computational techniques in the treatment of neurodegenerative diseases.
Artemisinin Attenuates Isoproterenol-induced Cardiac Hypertrophy via the
ERK1/2 and p38 MAPK Signaling Pathways
Authors: Song Renxing , Xiong Chunming , Bai Juncai , Bai Zhenzhou , Liu Wei 
Published: October 2023

Background:
Artemisinin (ART) is mainly derived from Artemisia annua, a traditional Chinese medicinal plant, and has been found to affect cellular
biochemical processes, such as proliferation, angiogenesis, and apoptosis, in addition to its antimalarial properties. However, its effect on cardiac
hypertrophy and the underlying mechanisms remain unclear.

Objective:
This study aimed to investigate the effect of ART on cardiac hypertrophy and explore its possible mechanisms.

Materials and Methods::
A rat model was established by intraperitoneal injection of isoproterenol (ISO) for 3 days, and the degree of myocardial hypertrophy was compared
among 5 groups: a control (CON) group, an ISO group, and groups treated with different doses of ART (7 mg/kg/d, 35 mg/kg/d, and 75 mg/kg/d).
Echocardiography was used to evaluate cardiac function and structure. The cross-sectional area of cardiomyocytes was measured by hematoxylin
and eosin (H&E) staining. The heart weight (HW), body weight (BW), and tail length were measured, and the HW/tail length ratio and the
HW/BW ratio were calculated. H9C2 rat cardiomyocytes were cultured, and different amounts of ART were added 2 hours before ISO stimulation.
Phalloidin staining was used to evaluate the degree of cell hypertrophy. The levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide
(BNP) were quantified in rat plasma and cell supernatant using enzyme-linked immunosorbent assay (ELISA), while the expression levels of p-
ERK1/2, p-JNK, and p-p38 MAPK were assessed in the myocardium and H9C2 cells via western blot analysis.

Conclusion:
The mechanism of ART against cardiac hypertrophy was related to inhibition of the ERK1/2 and p38 MAPK signaling pathways.

Result:
Intragastric administration of ART at a dosage of 35 mg/kg/d or over-mitigated the early-stage cardiac hypertrophy induced by ISO in rats led to a
reduction in left ventricular posterior wall diastolic thickness, interventricular septal thickness at diastole, lowered ANP and BNP levels, as well as
a decrease in HW/tail length and HW/BW ratio. In vitro studies demonstrated that ART at a concentration of 100 μM inhibited ISO-mediated
hypertrophy of H9C2 cells. The ISO group showed a higher p-ERK/GAPDH ratio and p-p38 MAPK/GAPDH ratio than the control group both in
vivo and in vitro. Although the p-JNK/GAPDH ratio was increased in the ISO group, there was no statistical difference. The p-ERK/GAPDH and
p-p38/GAPDH ratios were significantly lower in the ART group than in the ISO group.
Antipyretic and Anti-inflammatory Effects of Sanchen Pediatric Antipyretic
Paste
Authors: Su Li De , Hurilebater  , Chao Lu Men , Sanchula  , Yu Dong , Amguleng  , Hao Jian Hui , Li Xin 
Published: October 2023

Objective::
This study aimed to investigate the antipyretic and anti-inflammatory effects
and mechanisms of Sanchen Pediatric antipyretic Paste (SPAP).

Methods::
Rats were randomly divided into 7 groups: negative control group, positive control group,
positive treatment group, SPAP high-dose, medium-dose and low-dose groups, and blank substrate
group. Except normal control group, rats in other groups were subcutaneously injected with 10% dry
yeast suspension (10mL/kg) on the back to establish a fever model, and the normal group was given
the same volume of saline. At the 4 h and 7 h after modeling, each treatment group was subjected to
corresponding SPAP intervention. Anal temperature was measured every one hour after modeling for
10 consecutive times. The average temperature-rise curve, maximum temperature and body temperature
response index (TRI) were calculated to evaluate the efficacy of SPAP. After the last temperature
measurement, abdominal aortic blood was collected, and serum was separated from blood. The
levels of IL-6, TNF-α and CRP in serum were determined by enzyme-linked immunosorbent assay.

Results::
The body temperature of the positive control group was significantly increased (p < 0.01) 4
hours after model establishment, and that of the SPAP groups significantly decreased (p < 0.01) after
5 hours of the model establishment. The levels of Serum IL-6, TNF-α and CRP were significantly
decreased (p < 0.01) in a dose-dependent manner.

Conclusion::
SPAP has an obvious antipyretic effect on fever caused by dry yeast in rats. One of its
antipyretic mechanisms may be associated with inhibiting inflammatory reactions by reducing the
production or accelerating the degradation of endogenous thermogenic cytokines, such as IL-6, TNF-
α, and CRP.
Protective Effects of Hydroalcoholic Leaf Extract of Origanum Vulgare
against Paraquat-induced Lung Toxicity in Rats: The Role of the
Inflammation-related Markers and Oxidative Stress
Authors: Sharifi-Rigi Ali , Heidarian Esfandiar , Zal Fatemeh 
Published: October 2023

Background::
The pesticide paraquat is hazardous to both humans and animals. Lung
damage is a common complication of paraquat poisoning.

Objective::
This research analyzes the preventive properties of Origanum vulgare leaf extract against
paraquat-induced acute pulmonary toxicity and oxidative stress.

Methods::
In this experiment, the rats were assigned to five distinct groups. Group 1 served as the
control, group 2 got only 25 mg/kg bw paraquat, and groups 3, 4, and 5 received paraquat and Origanum
vulgare leaf extract at dosages of 200, 400, and 800 mg/kg bw, respectively. In rats, inflammation-
related indicators and oxidative stress were analyzed after therapy.

Results::
Compared with the control group, the levels of the serum PC, MDA, and inflammatory
markers such as TNF-α, IL-6, and IL-1β remarkably rose (p < 0.05) and the pulmonary contents of
the SOD, CAT, and vitamin C greatly decreased (p < 0.05) in the paraquat-only group. Origanum
vulgare leaf extract administration after paraquat exposure resulted in a substantial increase in lung
SOD, CAT, and vitamin C levels as well as a significant reduction in MDA, PC, and lung
inflammatory markers (TNF-α, IL-6, and IL-1β) gene expression relative to the paraquat-only group.

Conclusion::
Origanum vulgare leaf extract might be supplied to lessen the toxicity of paraquat,
based on the findings of this research, which indicated that Origanum vulgare leaf extract has antioxidant-
enhancing properties and can improve the antioxidant defense system.

other:
Ethic number: IR. SKUMS. REC. 1395. 151.
Potential Herbal Remedies for Treatment of Depression: A Mini Review
Authors: Yadav Khushbu , Rani Anjna , Dua Kamal 
Published: October 2023

Background::
Depression is a psychiatric and mood disorder that impacts a person's mental
health and behavior and is frequently linked to suicide. As per the World Health Organization's
estimate, depressive disorder will be the main cause of mental disorders by the year 2030, and it has
a huge impact on the burden of disease in the world. To treat depression, there are pharmacological
and nonpharmacological therapy alternatives. With little to no consideration of other neurochemicals
altered in depression, most antidepressant preparations are based on the monoamines, neuroendocrine,
and neuro-inflammation concepts.

Objective::
The present study aims to provide comprehensive data related to depression, the factors
associated, the mechanism involved, herbal plants effective for managing depression, and novel formulations
along with patents and clinical trials.

Methods::
A thorough assessment of herbs and novel formulations that have been proven effective in
treating depression was conducted. After extensive review, the present study includes a mechanism
of action of herbal plants showing antidepressant effects, novel formulations, patents, and clinical
trials related to depression.

Results::
Numerous studies reported that diverse herbal plants have been found to have a positive
effect on depression management, such as Panax ginseng, Melissa officinalis, Piper methysticum,
Schinus molle L, Kielmeyera coriacea Mart, Elaeocarpus ganitrus, Hypericum perforatum, Lavandula
angustifolia Mill, Crocus Sativus L.

Conclusion::
Herbal plant research could help establish the potential of isolated compounds from
plants with medicinal properties for managing depressive illnesses.
Virus de la leucemia bovina: entre la producción animal y la salud humana
Authors: Paternina B Daniela , González T Marco , Mattar V Salim 
Published: October 2023

El virus de la leucemia bovina (BLV) es un retrovirus del género deltaretrovirus, el cual infecta los linfocitos B y genera una expansión policlonal. En los rumiantes se integra como provirus al genoma del huésped y genera una infección de por vida. a lo largo de la vida. Según la Organización Mundial de Sanidad Animal (WOAH) es una enfermedad de importancia internacional para el comercio de animales (1). Es conocida como la mayor enfermedad neoplásica del ganado bovino y hace parte de los cinco agentes virales más importantes en la producción pecuaria (2,3).