bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal association of mindfulness with aggression and non‐suicidal self‐injury in adolescence: The mediating role of shame‐proneness
Authors: Zhang Ruotong , Chen Jing , Zhang Chunyang , Xu Wei 
Published: November 2023

AbstractThe aim of the current study was to investigate the longitudinal association of facets of mindfulness with aggression and non‐suicidal self‐injury (NSSI) among adolescents and to explore whether shame‐proneness can mediate the longitudinal association. The present longitudinal study investigated the associations between mindfulness, aggression, and NSSI in a sample of 706 Chinese adolescents (M = 15.33; SD = 1.34; 50.20% girls). Five facet mindfulness questionnaire was completed at baseline and middle school students' shame scale was completed at 6‐month follow‐up. The Chinese version of Buss−Perry aggression questionnaire and adolescents' self‐harm scale were completed at both baseline and 6‐month follow‐up. Shame‐proneness significantly mediated the longitudinal association between (a) describing and aggression (−0.107, 95% CI: [−0.151 to −0.067]), and NSSI (−0.041, 95% CI: [−0.069 to −0.019]). (b) Acting with awareness and aggression (−0.094, 95% CI: [−0.139 to −0.061]), and NSSI (−0.036, 95% CI: [−0.062 to −0.016]). (c) Nonjudging and aggression (−0.062, 95% CI: [−0.107 to −0.024]) and NSSI (−0.024, 95% CI: [−0.047 to −0.008]). Describing, acting with awareness, and nonjudging were predictive factors of aggression and self‐injury in adolescents, and shame‐proneness played a crucial role in the negative longitudinal association between them. Findings from the current study may offer some implications in the domains of clinical practice and education to improve mental health and further ameliorate the misbehavior among adolescents.
Machine learning‐based radiomics nomograms to predict number of fields in postoperative IMRT for breast cancer
Authors: Mao Yichen , Di Wenyi , Zong Dan , Mu Zhongde , He Xia 
Published: November 2023

AbstractBackgroundBreast cancer is now the most commonly diagnosed cancer in women worldwide. Radiotherapy is an important part of the treatment for breast cancer, while setting proper number of fields dramatically affects the benefits one can receive. Machine learning and radiomics have been widely investigated in the management of breast cancer. This study aims to provide models to predict the best number of fields based on machine learning and improve the prediction performance by adding clinical factors.MethodsTwo‐hundred forty‐two breast cancer patients were retrospectively enrolled for this study, all of whom received postoperative intensity modulated radiation therapy. The patients were randomized into a training set and a validation set at a ratio of 7:3. Radiomics shape features were extracted for eight machine learning algorithms to predict the number of fields. Univariate and multivariable logistic regression were implemented to screen clinical factors. A combined model of rad‐score and clinical factors were finally constructed. The area under receiver operating characteristic curve, precision, recall, F1 measure and accuracy were used to evaluate the model.ResultsRandom Forest outperformed from eight machine learning algorithms while predicting the number of fields. Prediction performance of the radiomics model was better than the clinical model, while the predictive nomogram combining the rad‐score and clinical factors performed the best.ConclusionsThe model combining rad‐score and clinical factors performed the best. Nomograms constructed from the combined models can be of reliable references for medical dosimetrists.
Sulfonium‐Cross‐Linked Hyaluronic Acid‐Based Self‐Healing Hydrogel: Stimuli‐Responsive Drug Carrier with Inherent Antibacterial Activity to Counteract Antibiotic‐Resistant Bacteria
Authors: Patel Anjali , Goswami Sanghamitra , Hazarika Gunanka , Sivaprakasam Senthilkumar , Bhattacharjee Surajit , Manna Debasis 
Published: November 2023

AbstractAugmentation of the activity of Food and Drug Administration‐approved antibiotics by an adjuvant or antibiotic carrier is considered one of the promising strategies to fight against antibiotic‐resistant bacteria. This study reports the development of sulfonium‐cross‐linked hyaluronic acid (HA)‐based polymer (HA‐SS‐HA) as an inherent antimicrobial agent and antibiotic carrier. The HA‐SS‐HA polymer offers the potential for encapsulating various classes of antibiotics and accomplishing a stimuli‐responsive release profile in the presence of hyaluronidase produced by bacterial cells within their extracellular environment. Systematic antibacterial studies reveal that the HA‐SS‐HA‐encapsulated antibiotics (vancomycin, amoxicillin, and tetracycline) restore its activity against the antibiotic‐resistant bacterial cells methicillin‐resistant Staphylococcus aureus (MRSA) and vancomycin‐resistant Enterococci (VRE), and Pseudomonas aeruginosa. The HA‐SS‐HA gel shows robust efficacy in eradicating the mature biofilm of Staphylococcus aureus (S. aureus). The membrane‐disrupting activity reveals that HA‐SS‐HA can also counteract the antibiotic resistance mechanism of the bacterial cells. The in vivo studies reveal excellent wound‐healing activity of HA‐SS‐HA in albino laboratory‐bred (BALB/c) mice. The outcome of additional antibacterial studies reveals that antibiotics‐encapsulated HA‐SS‐HA hydrogel can effectively combat Gram‐negative, Gram‐positive, and antibiotic‐resistant bacterial strains. Therefore, revitalizing the activity of commercial antibiotics by HA‐SS‐HA can be considered a valuable and economically effective strategy to fight against antibiotic‐resistant bacteria.
Anisotropic Superconducting Nb2CTx MXene Processed by Atomic Exchange at the Wafer Scale
Authors: Xu Xiangming , Zhang Chenghui , Yin Jun , Smajic Jasmin , Bahabri Mohammed , Lei Yongjiu , Hedhili Mohamed Nejib , Hota Mrinal K. , Shi Lin , Guo Tianchao , Zheng Dongxing , El‐Demellawi Jehad K. , Lanza Mario , Costa Pedro M. F. J. , Bakr Osman M. , Mohammed Omar F. , Zhang Xixiang , Alshareef Husam N. 
Published: November 2023

AbstractSuperconductivty has recently been induced in MXenes through surface modification. However, the previous reports have mostly been based on powders or cold‐pressed pellets, with no known reports on the intrinsic superconsucting properties of MXenes at the nanoale. Here, it is developed a high‐temperature atomic exchange process in NH3 atmosphere which induces superconductivity in either singleflakes or thin films of Nb2CTx MXene. The exchange process between nitrogen atoms and fluorine, carbon, and oxygen atoms in the MXene lattice and related structural adjustments are studied using both experiments and density functional theory. Using either single‐flake or thin‐film devices, an anisotropic magnetic response of the 2D superconducting transformation has been successfully revealed. The anisotropic superconductivity is further demonstrated using superconducting thin films uniformly deposited over a 4 in. wafers, which opens up the possibility of scalable MXene‐based superconducting devices.
Laser‐Induced Electron Synchronization Excitation for Photochemical Synthesis and Patterning Graphene‐Based Electrode
Authors: Yuan Yongjiu , Huang Junhao , Li Xin , Jiang Lan , Li Tong , Sun Pengcheng , Yin Yingying , Wang Sumei , Cheng Qian , Xu Wanghuai , Qu Liangti , Wang Steven 
Published: November 2023

AbstractMicro‐supercapacitors (MSCs) represent a pressing requirement for powering the forthcoming generation of micro‐electronic devices. The simultaneous realization of high‐efficiency synthesis of electrode materials and precision patterning for MSCs in a single step presents an ardent need, yet it poses a formidable challenge. Herein, a unique shaped laser‐induced patterned electron synchronization excitation strategy has been put forward to photochemical synthesis RuO2/reduced graphene oxide (rGO) electrode and simultaneously manufacture the micron‐scale high‐performance MSCs with ultra‐high resolution. Significantly, the technique represents a noteworthy advancement over traditional laser direct writing (LDW) patterning and photoinduced synthetic electrode methods. It not only improves the processing efficiency for MSCs and the controllability of laser‐induced electrode material but also enhances electric fields and potentials at the interface for better electrochemical performance. The resultant MSCs exhibit excellent area and volumetric capacitance (516 mF cm−2 and 1720 F cm−3), and ultrahigh energy density (0.41 Wh cm−3) and well‐cycle stability (retaining 95% capacitance after 12000 cycles). This investigation establishes a novel avenue for electrode design and underscores substantial potential in the fabrication of diverse microelectronic devices.
A Guide for Cross‐Linking Modulation: The Record Rectifying Ratio of Hydrogel‐Based Ultra Flexible Ionic Diodes
Authors: ÖZBAY KARAKUŞ Mücella 
Published: November 2023

AbstractThis study focuses on the effect of cross‐linking mechanisms in the development of hydrogel‐based flexible ionic diodes (HBIDs) with desirable features for ionic devices. The research explores one p‐type hydrogel and a series of n‐type hydrogels with varying cross‐linking ratios, investigating their ion‐conducting properties, morphological and electronic structures, as well as the performance of flexible HBIDs constructed using these hydrogels. The results indicate that the cross‐linking ratio significantly influences ionic conductivity, bulk resistance, and capacitance. Additionally, the HBIDs' ability to maintain their electrical performance under repeated mechanical bending is studied concerning the cross‐linking ratio. Notably, the HBID with the highest cross‐linking ratio (HG/12) exhibits relatively higher current densities (up to 8.9 mA cm−2) and considerably higher rectification ratios (up to 1269). Even after 500 cycles of deformation, the HG/12 diode maintained a rectification ratio of 987, demonstrating its excellent performance and durability.
A Micrometric Transformer: Compositional Nanoshell Transformation of Fe3+‐Trimesic‐Acid Complex with Concomitant Payload Release in Cell‐in‐Catalytic‐Shell Nanobiohybrids
Authors: Park Joohyouck , Kim Nayoung , Han Sang Yeong , Rhee Su Yeon , Nguyen Duc Tai , Lee Hojae , Choi Insung S. 
Published: November 2023

AbstractNanoencapsulation of living cells within artificial shells is a powerful approach for augmenting the inherent capacity of cells and enabling the acquisition of extrinsic functions. However, the current state of the field requires the development of nanoshells that can dynamically sense and adapt to environmental changes by undergoing transformations in form and composition. This paper reports the compositional transformation of an enzyme‐embedded nanoshell of Fe3+‐trimesic acid complex to an iron phosphate shell in phosphate‐containing media. The cytocompatible transformation allows the nanoshells to release functional molecules without loss of activities and biorecognition, while preserving the initial shell properties, such as cytoprotection. Demonstrations include the lysis and killing of Escherichia coli by lysozyme, and the secretion of interleukin‐2 by Jurkat T cells in response to paracrine stimulation by antibodies. This work on micrometric Transformers will benefit the creation of cell‐in‐shell nanobiohybrids that can interact with their surroundings in active and adaptive ways.
Inkjet‐Printed, Wafer‐Scale Organic Schottky‐Gate Transistors toward Single‐Battery‐Driven Integrated Logic
Authors: Hao Ziqian , Qian Jun , Li Yating , Dai Qinyong , Li Longfei , Xie Jiacheng , Sun Li , Wang Xiaomu , Wang Xinran , Shi Yi , Li Yun 
Published: November 2023

AbstractOrganic field‐effect transistors switched by insulated gates are the most essential building blocks, while usually plagued with degraded gate control arising from complicated dielectric engineering. Subsequently, the resulting large supply voltage and power consumption remain an essential issue for portable electronics driven by a single battery of only 1.5 V. Herein, wafer‐scale organic Schottky‐gate transistor arrays using inkjet‐printed few‐layer organic semiconducting crystals are reported. The transistors exhibit steep switching characteristics with an average subthreshold swing of 55 mV per dec and high signal amplification efficiency over 45 S A‐1, attributed to efficient Schottky gating and enhanced charge injection. Thereafter, high‐gain inverters are successfully demonstrated with an ultralow power consumption of only 800 pW; also, they are integrated as 1 V driven sequential logic circuits. A coplanar double‐gate geometry is also introduced for low‐voltage, single‐device AND logic. Therefore, the work opens new avenues toward the sustainable advancement in single‐battery‐driven, ultralow‐power organic electronics.
A P/N synergistic flame retardant containing flexible nitrile group for enhancing the mechanical properties and fire safety of epoxy resins
Authors: Li Junwei , Ma Qiuju , Liu Quanyi , Zheng Penglun 
Published: November 2023

AbstractTo further enhance the fire safety of epoxy resins, a phosphorus–nitrogen synergistic flame retardant (DPVHD) with a flexible chain segment and a nitrile group was synthesized. In addition to the traditional flame retardant elements P and N, the flame retardancy of the epoxy composites is further enhanced by the cross‐linking effect of the nitrile groups introduced to form an interpenetrating network with the epoxy matrix. The results showed that the sample with 10 wt% DPVHD‐10/EP had a LOI of 32.3% and passed the UL‐94 V‐0 rating, with PHRR and THR reduced by 15.4% and 47%, respectively, compared to pure EP. It is worth noting that the introduction of flexible chain segments improves the flexural properties of the epoxy resin matrix. Compared with pure epoxy, the flexural properties of epoxy‐cured compounds with DPVHD addition show a rising trend with the increase of flame‐retardant additive. And the rise of DPVHD‐10/EP reaches 33.6%, which greatly reduces the negative effect of flame‐retardant additives on the mechanical properties of the epoxy resin matrix. This work therefore provides new ideas for exploiting the advantages of phosphorus‐nitrogen synergy and nitrile‐based cross‐linking for flame retardancy in epoxy resins.
Monitoring Source Water Quality Adds Value at Loveland Water and Power
Authors: Fayram Andrew H. , Bohling Timothy M. 
Published: November 2023

Key TakeawaysSource water quality monitoring programs benefit from sampling efforts that address data needs on different spatial and temporal scales.The cost of monitoring programs is more than offset by real savings, avoided costs, and increased support for decision makers.Loveland Water and Power has derived diverse and sometimes unexpected benefits from its monitoring program.
Chemo‐Enzymatic Synthesis of Isomeric I‐branched Polylactosamines Using Traceless Blocking Groups
Authors: Vos Gaёl M. , Wu Yunfei , van der Woude Roosmarijn , de Vries Robert P. , Boons Geert‐Jan 
Published: November 2023

AbstractPoly‐N‐acetyl lactosamines (polyLacNAc) are common structural motifs of N‐ and O‐linked glycan, glycosphingolipids and human milk oligosaccharides. They can be branched by the addition of β1,6‐linked N‐acetyl‐glucosamine (GlcNAc) moieties to internal galactoside (Gal) residues by the I‐branching enzyme beta‐1,6‐N‐acetylglucosaminyltransferase 2 (GCNT2). I‐branching has been implicated in many biological processes and is also associated with various diseases such as cancer progression. Currently, there is a lack of methods that can install, in a regioselective manner, I‐branches and allows the preparation of isomeric poly‐LacNAc derivatives. Here, we described a chemo‐enzymatic strategy that addresses this deficiency and is based on the enzymatic assembly of an oligo‐LacNAc chain that at specific positions is modified by a GlcNTFA moiety. Replacement of the trifluoroacetyl (TFA) moiety by tert‐butyloxycarbonyl (Boc) gives compounds in which the galactoside at the proximal site is blocked from modification by GCNT2. After elaboration of the antennae, the Boc group can be removed, and the resulting amine acetylated to give natural I‐branched structures. It is also shown that fucosides can function as a traceless blocking group that can provide complementary I‐branched structures from a single precursor. The methodology made it possible to synthesize a library of polyLacNAc chains having various topologies.
Die Fenster in den Prozess nutzen
Authors: Gandert Etwina 
Published: November 2023

AbstractMit den wachsenden Anforderungen an Anlageneffizienz und Produktqualität hat auch die Nachfrage nach Prozessanalysentechnik (PAT) zugenommen. Sie bietet Fenster in den Prozess. Dr. Martin Gerlach, Head of Process Analytical Technologies bei Bayer und Mitglied des erweiterten Vorstands des Arbeitskreis PAT, bietet im Interview mit CITplus einen überblick über die Möglichkeiten und Nuzten von PAT, um den Anforderungen gerecht zu werden.
Analyse der Wasserstoffqualität im Ex‐Bereich
Authors: Aust Alexander 
Published: November 2023

AbstractDie Prüfung des Wasserstoffreinheitsgrads an Wasserstofftanksäulen ist wichtig, um Schäden bei der Nutzung zu vermeiden. Um nicht als Zündquelle zu fungieren, muss Equipment zur Wasserstoffanalyse in explosionsgefährdeten Zonen ohne ATEX‐ oder IECEx‐Zertifizierung besonders geschützt werden. Dafür sind überdruckgekapselte (Ex‐p) Gehäuse eine geeignete Lösung.
PFAS Belastungen im Trinkwasser
Authors: Raiser Jan 
Published: November 2023

AbstractEine Belastung von Trinkwasser mit PFAS ist unerwünscht und gesundheitsgefährdend. Anhand eines Anwendungsbeispiels im Rohwasserpumpwerk Creglingen wird mithilfe einer vergleichenden Untersuchung zur Rückhaltung von Metaboliden des Pflanzenschutzmittels Chloridazon die Trinkwasseraufbereitung unter Bezugnahme auf PFAS dargestellt. Dabei wird die Filterleistung von Aktivkohle auf Kokosnussbasis mit Aktivkohle auf Steinkohlebasis verglichen.
Bibliometric analysis of Traditional Chinese Medicine nanoparticles research from 2005 to 2023
Authors: Zhong Dayuan , Cheng Hui , Liu Huixian , Feng Shihui , Liu Yumei , Xiang Huier , Chen Jiaqi 
Published: November 2023

AbstractTo gain a deeper understanding of the current status of research on Traditional Chinese Medicine (TCM) and nanoparticles, we conducted a bibliometric study. We conducted a literature search in the Web of Science (WOS) for publications related to TCM and nanoparticles from 1992 to 2023. The data, including countries of publication, research institutions, journals, citations, and keywords, were analyzed using the Bibliometrix R‐4.0 software package. We performed an analysis to identify the co‐occurrence of keywords in the documents including their titles and abstracts. From 2005 to 2023, a total of 309 publications were included, with an average annual growth rate of 4.25%. The majority of these publications were published in Q1 journals (72, 47.06%) and Q2 journals (45, 29.41%). Among the 309 publications, 22 articles (7.12%) had an impact factor greater than 10, while 78 articles (25.24%) had an impact factor greater than 5. The analysis of international collaboration networks revealed limited international cooperation, with most collaborations occurring between institutions in China, the United States, and Australia. These 309 publications involved a total of 438 research institutions, with Chinese research institutions being the most prolific contributors. In this study, a total of 309 publications were included, comprising 1142 author keywords and 1175 keywords plus. Factor analysis of the 1175 keywords plus revealed that they could be grouped into five categories: one category included terms such as “oxide” and “zinc,” another category included terms like “lipid” and “acid,” a third category included terms such as “improve” and “enhance,” a fourth category included terms like “silica” and “mesoporous,” and the fifth category included terms like “PLGA” and “immune.” Research on nanoparticles in TCM has been gradually gaining popularity. Currently, most of the research in this field is conducted in China, with limited international collaboration. The majority of TCM nanoparticle research focuses on individual herbal compounds, while research on nanoparticle formulations of traditional herbal prescriptions is relatively scarce.
Advances in cardiac tissue engineering and heart‐on‐a‐chip
Authors: Kieda Jennifer , Shakeri Amid , Landau Shira , Wang Erika Yan , Zhao Yimu , Lai Benjamin Fook , Okhovatian Sargol , Wang Ying , Jiang Richard , Radisic Milica 
Published: November 2023

AbstractRecent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled. The elongated structure of cardiomyocytes requires tuning of substrate properties and application of biophysical stimuli to drive its mature phenotype. Landmark advances have already been achieved with induced pluripotent stem cell‐derived cardiac patches that advanced to human testing. Heart‐on‐a‐chip platforms are now commonly used by a number of pharmaceutical and biotechnology companies. Here, we provide an overview of cardiac physiology in order to better define the requirements for functional tissue recapitulation. We then discuss the biomaterials most commonly used in both cardiac tissue engineering and heart‐on‐a‐chip, followed by the discussion of recent representative studies in both fields. We outline significant challenges common to both fields, specifically: scalable tissue fabrication and platform standardization, improving cellular fidelity through effective tissue vascularization, achieving adult tissue maturation, and ultimately developing cryopreservation protocols so that the tissues are available off the shelf.
Curcumin inhibits the activity and induces apoptosis of activated hepatic stellate cell by suppressing autophagy
Authors: Shu Yongxiang , He Yajun , Ye Guorong , Liu Xuyou , Huang Jiahuang , Zhang Qinghui , Tian Da , Wang Tengyan , Shu Jianchang 
Published: November 2023

AbstractCurcumin, a kind of natural compound, has been previously proven to inhibit the autophagy in hepatic stellate cells (HSCs) and induce their apoptosis. However, it is not clear whether the enhanced apoptosis of activated HSCs (aHSCs) caused by curcumin depends on autophagy inhibition. We aim to verify this hypothesis and explore the potential mechanisms in this study. Immortalized human HSC line LX‐2 was used as an experimental specimen and pretreated with transforming growth factor β1(TGF‐β1) for 24 h to activate it before drug application. The levels of autophagy, apoptosis, cell activity, lipid metabolism, and the activity of the PI3K/Akt/mTOR signal pathway were evaluated by multiple methods, such as Western blotting, mcherry‐EGFP‐LC3B adenoviruses transfection, immunofluorescence, Nile Red staining, flow cytometry among others. Our results showed that rapamycin, an autophagy activator, could partly offset the effects of curcumin on autophagy and apoptosis of LX‐2 cells, while 3‐Methyladenine (3‐MA), an autophagy inhibitor, could enhance these effects. Furthermore, curcumin could promote the activity of the PI3K/Akt/mTOR signal pathway in LX‐2 cells, while PI3K inhibitor could partly offset this effect and increase the autophagy level. Overall, we demonstrated that curcumin could inhibit the activity and promote LX‐2 cells apoptosis by suppressing autophagy by activating the PI3K/Akt/mTOR signal pathway. In addition, lipid recovery and energy deprivation due to autophagy inhibition may be the exact mechanism by which curcumin attenuates the pro‐fibrotic activity of LX‐2.