bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplikasi TikTok dengan Model PBLA untuk Meningkatkan Kemampuan Argumentasi Peserta Didik pada Konsep Pengukuran Fisika
Authors: Prastiwi Ayu Nita , Fatmaryanti Siska Desy , Akhdinirwanto Raden Wakhid 
Published: January 2025

Penelitian ini bertujuan untuk mengembangkan media pembelajaran dengan memanfaatkan aplikasi TikTok dengan model PBLA pada materi pengukuran dan mengetahui peningkatan kemampuan argumentasi peserta. Penelitian menggunakan penelitian pengembangan (Research and Development/ R & D) dengan prosedur pengembangan ADDIE (Analyze, Design, Development, Implementation, and Evaluation). Subjek penelitian yang digunakan dalam penelitian ini adalah 36 peserta didik kelas X MAN Purworejo. Instrumen yang digunakan dalam penelitian yaitu lembar validasi, lembar angket respon peserta didik, lembar observasi, soal pretest-postest, dan lembar keterlaksanaan pembelajaran. Hasil analisis data penelitian menunjukkan bahwa media pembelajaran fisika menggunakan aplikasi TikTok dengan model PBLA memenuhi kriteria “valid” dengan hasil validasi ahli materi mendapat nilai sebesar 3,45 dengan persentase sebesar 86,30%, termasuk dalam kategori “baik” dan hasil validasi ahli media mendapatkan nilai sebesar 3,58 dengan persentase sebesar 89,58% dalam kategori “sangat baik”. Media video pembelajaran fisika menggunakan aplikasi TikTok dengan model PBLA dikembangkan melalui uji respon peserta didik terhadap penggunaan media video pembelajaran Fisika menggunakan aplikasi TikTok dengan model PBLA mendapatkan skor 85,5% dengan predikat “sangat baik”. Sedangkan data hasil observasi keterlaksanaan pembelajaran mendapatkan skor Percentage Agreement (PA) sebesar 99% dengan predikat “reliabel” sehingga memenuhi kriteria “praktis”. Pemanfaatan aplikasi TikTok dengan model PBLA efektif berdasarkan hasil uji coba menggunakan paired sample t-test diperoleh nilai t hitung 0.000 < 0.05, yang artinya terdapat peningkatan keterampilan argumentasi setelah menggunakan media pembelajran fisika dengan aplikasi TikTok. Dengan demikian, media pembelelajaaran fisika yang dikembangkan “efektif” digunakan untuk meningkatkan keterampilan argumentasi peserta didik berdasarkan perolehan nilai pretest dan posttest dengan normalized gain dengan skor sebesar 0,71 dan masuk dalam kategori “tinggi”.
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Literasi Sains Pada Materi Pencemaran Lingkungan
Authors: Mudumi Sahfitri , Irianti Mustika , Kumalasari Lina 
Published: January 2025

Pengembangan bahan ajar berupa Lembar Kerja Peserta Didik Berbasis Literasi Sains pada materi Pencemaran Lingkungan di SMP Negeri 01 Raja Ampat telah dilakukan untuk mengatasi permasalahan kekurangan penggunaan bahan dan sumber pembelajaran terkhususnya yang berbasiskan Literasi Sains disekolah tersebut. Tujuan terlaksanaanya penelitian ini adalah untuk menilai kelayakan berupa kevalidan, keefektifan dan kepraktisan LKPD Berbasis Literasi Sains yang telah dikembangkan serta mengukur keefektifan penggunaan LKPD Berbasis Literasi Sains terhadap pengetahuan peserta didik pada materi pencemaran lingkungan. LKPD Berbasis Literasi Sains dikembangkan dengan menggunakan model ADDIE, yang mencakup lima tahapan pengembangan, yaitu analisis (analysis), desain (design), pengembangan (development), penerapan (implementation), dan evaluasi (evaluation). Data pada penelitian ini dikumpulkan dengan penggunaan angket validasi, angket respon siswa serta soal pretest dan posttest. Berdasarkan hasil validasi menunjukkan bahwa LKPD Berbasis Literasi Sains pada materi Pencemaran Lingkungan mendapatkan tingkat validasi dari ahli materi sebesar 96,43% dengan kriteria sangat layak, dan dari ahli media sebesar 85,83% yang juga dengan kriteria sangat layak. Adapun hasil keefektifan LKPD Berbasis Literasi Sains diperoleh hasil belajar peserta didik dengan kategori Tinggi dengan perolehan nilai n-gain ≥ 0,7. Respon peserta didik menunjukan bahwa sebanyak 12 peserta didik memberikan respon positif terhadap penggunaan LKPD Berbasis Literasi Sains dengan presetase 95%. Sehingga dapat disimpulkan LKPD Berbaisis Literasi dapat digunakan dalam pembelajaran.
Profile of Ecoliteracy Ability of Science Students On Environmental Issues
Authors: Taufik Annisa Novianti , Berlian Liska , Wahyuni Ajeng Restu , Khofifah Mia 
Published: January 2025

ABSTRAK
Penelitian ini bertujuan untuk memberikan gambaran tentang profil kemampuan ekoliterasi mahasiswa dalam konteks isu lingkungan seperti sampah, kerusakan hutan dan perubahan iklim. Jenis penelitian ini adalah deskriptif kualitatif untuk memperoleh informasi terkait tingkat keterampilan ekoliterasi mahasiswa semester IV. Teknik pengambilan sampel menggunakan random sampling dengan jumlah 27 orang mahasiswa IPA Angkatan 2022. Instrumen penelitian yang digunakan adalah penilaian diri yang menyesuaikan dengan indikator penilaian memelihara kelestarian lingkungan, menggunakan energi dengan baik dan memanfaatkan sumber daya yang ada dengan prinsip ekologi. Hasil penelitian diperoleh bahwa tingkat keterampilan ekoliterasi mahasiswa memperoleh rata-rata persentase sebesar 71% dan berada pada kategori baik. Temuan ini menunjukkan sebagian besar mahasiswa telah memiliki pemahaman ekoliterasi dan mampu mempraktikkanya dengan baik melalui tindakan yang berorientasi pada nilai keberlanjutan.
Kata kunci: Kemampuan Ekoliterasi; Isu Lingkungan; Keberlanjutan.
The Use of Telang Flower Extract (Clitoria ternatea L.) as a Natural Universal pH Indicator coupled with Digital Image Colorimetry
Authors: Esterlin  , Nursaadah Euis , Wardana Rendy W. , Firdaus M. Lutfi 
Published: January 2025

The acid base indicators commonly used by scientists are mostly synthetic indicators that are harmful for the environment.Moreover, chemists need various chemicals to detect broad pH ranges for acid and base samples solution. The aim of this research was to create a natural universal pH indicator from telang flower (Clitoria ternatea L.) extract coupled with the digital image detection. The universal pH indicator is very important in education chemistry that broadly used for titration and other class room chemical experiments. This process of making a natural universal pH indicator integrated with digital images meets green chemistry criteria that use environmentally friendly materials and technology. The results show that color absorption data at pH 1-2 are purple, pH 3-5 are violet, pH 6-10 are blue, pH 11-12 are green and pH 13-14 are yellow. RGB intensity digital image data shows the intensity of the red color increases in the pH range 6-11, while the intensity of the green and blue colors tends to be stable. The proposed method was validated using a UV-Vis spectrophotometer and conventional pH meter that give the comparable results.
System- and fish-size-specific reference intervals for plasma analytes in Atlantic salmon (Salmo salar L.) reared in commercial fresh- and saltwater recirculating aquaculture systems: a descriptive study
Authors: Amlie Thomas , Persson David , Nørstebø Simen Foyn , Østvik Asgeir , Stormoen Marit , Evensen Øystein 
Published: January 2025

IntroductionIn aquaculture, clinical chemistry can be used pre-emptively to manage fish health and for early disease intervention. While less established in farmed fish compared to farmed terrestrial animals, it has been used for salmonid cage farming but is almost non-existent in recirculation aquaculture systems (RAS) for Atlantic salmon (Salmo salar L.). In this descriptive study, the level and distribution of selected biochemical plasma analytes from different weight classes of Atlantic salmon reared in commercial RAS facilities maintained in either freshwater or saltwater were determined.MethodsFacility 1 focused on the production of fry to smolt at a salinity of 0.5-2 ppt, and Facility 2 produced fish from smolt to market size. Four fish groups (FG) were included: FG 1-2 in Facility 1 and FG 3-4 in Facility 2. Fish in Facility 1 were sampled monthly, while fish in Facility 2 were sampled at varying intervals (between 4 and 19 weeks) to determine selected biochemical analytes. The study spanned 100-250 days, depending on the fish group. Biochemical analyses included sodium, chloride, potassium, osmolality, calcium, magnesium, total protein, albumin, and globulin. In addition, water quality parameters measured included temperature, salinity, NH4-N, NO2, NO3, color, turbidity, alkalinity, CO2, H2S, and gas pressure.ResultsResults indicated that selected blood analytes of Atlantic salmon were influenced by the production environment (freshwater or saltwater). In addition, there was an effect of fish weight, but variable for the different analytes. Water quality parameters varied with time and system; however, were within acceptable ranges in both production environments. No clear impact biochemical values were found from variations in water quality parameters.DiscussionThese results underscore the need for future research into system/environment-specific reference intervals and a better understanding of how fish weight impacts clinical chemical parameters. Factors that encompass water quality, management practices, fish strain/batch (i.e., stress tolerance), and the physiological status of the fish need to be considered and can influence obtained reference intervals. A threshold for acceptable prevalence and degree of exterior deviations should be defined. Reference values should then be compared to analyte levels in fish with known diseases to assess the diagnostic value of blood sampling.
The impact of architectural modifications on relative resistance to fluid flow in ventricular catheters
Authors: Madhavan Rajesh Kumar , Faryami Ahmad , Tappen Nathan , Gopalakrishnan Pranav , Ajaz Shaheer H. , Harris Carolyn A. 
Published: January 2025

IntroductionAlthough many ventricular catheter designs exist for hydrocephalus treatment, few standardized studies assess outflow resistance and the impact of design modifications on shunt drainage. This study represents the in-vitro assessment of various architectural modifications on catheter flow rate and pressure, focusing on bulk outflow dynamics and occlusion with whole blood-inoculated cerebrospinal fluid.MethodsCatheters were manufactured utilizing a novel catheter production setup with 16 variations from standard catheters, including but not limited to changes in: hole number, hole dimensions, catheter lumen dimension, and catheter lumen impingement. These catheters were tested in a portable custom-made ventricular catheter testing device to analyze relative resistance to flow between catheter designs. A subset of catheters with varying lumen diameters was tested in 0.30 mL/min saline flow with 2.5% blood to simulate early blood exposure.ResultsWith increasing hole and lumen diameter, we found a significant decrease in overall catheter relative resistance using DIH20 (P &lt; 0.001 and P &lt; 0.002 respectively, n = 5). With increasing lumen diameters, blood assays showed a significant increase in the time to complete obstruction (P = 0.027, n = 5). Lumen impingement, representing one obstruction-based pinch point in the lumen, showed a considerable increase in relative resistance as obstruction diameter increased and lumen diameter at the pinch point decreased (P = 0.001, n = 5). Removal of specific catheter hole rows trended toward an increase relative resistance after 75% of catheter holes were blocked, but the effect in relative outflow resistance is otherwise minimal (P &gt; 0.05, n = 5) and no effect was observed with blocking segments.ConclusionThis study implemented a novel method of rapid catheter manufacturing to systematically produce ventricular catheters with specific catheter architecture. By testing variables independently, we found that catheters with changes to the lumen diameter had the most dramatic shifts in overall relative resistance between catheter designs. Similarly, testing in the acute in-vitro blood assay demonstrated that smaller diameter catheters have a higher propensity to obstruct with blood compared to catheters with larger diameter. Relative resistance impacts fluid outflow efficiency, which may translate to clinical outcomes for hydrocephalus patients. These findings help us understand catheter architectural effects on resistance and inform future designs for specific ventricle morphologies.
Dynamic balance control in healthy young women during stair descent: a plantar pressure-based study
Authors: Wang Ruiqin , Cao Jinfeng , Xu Haoran , Guo Panjing , Li Yumin , Fan Yuyi , Gui Yunfei , Li Leqi , Adams Roger , Han Jia , Lyu Jie 
Published: January 2025

BackgroundWomen are more likely to fall or even die when the ladder falls, which seriously affects the quality of daily life. It is necessary to better understand the plantar mechanism of the ladder falls and put forward reasonable suggestions.MethodTwenty healthy young women volunteered to participate in the experiment. The study used the F-scan plantar pressure to explore the difference in the plantar pressure in the dominance of the leading foot across four step descent height conditions. The landing strategy employed was recorded during the experiment. The Center of Pressure (COP), along with its medial-lateral (ML) and anterior-posterior (AP) adjustment velocities, and the VCOP, RCOP-ML, and RCOP-AP were analyzed.ResultWith an increase in the step height, significant enhancements were observed in the VCOP-ML (p &lt; 0.001), VCOP-AP (p &lt; 0.001), RCOP-ML (p &lt; 0.001), and RCOP-AP (p &lt; 0.001) during landing. There was no significant difference in the kinematic parameters of plantar pressure during stair descent, regardless of whether the dominant foot or non-dominant foot was the leading foot.ConclusionThis study found that among young women, an increase in step height during descent significantly affected the plantar pressure and led to greater COP adjustment in the directions of ML and AP, increasing the risk of injury. At a step height of 5 cm, the first choice of the landing strategy for female subjects began to change from the hindfoot to the forefoot. Although there were no significant differences in plantar pressure data and landing strategies between subjects using the dominant side and nondominant side as the forefoot, the dominant side forefoot exhibited better postural balance control than the nondominant side forefoot.
4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets
Authors: Romero Angel H. , Delgado Francisco 
Published: January 2025

Leishmaniasis is one of the most important neglected tropical diseases, with more than two million new cases annually. It is endemic in several regions worldwide, representing a public health problem for more than 88 countries, in particular in the tropical and subtropical regions of developing countries. At the moment, there are neither approved vaccines nor effective drugs for the treatment of human leishmaniasis for any of its three typical clinical manifestations, and, importantly, the drugs of clinical use have several side effects, require complex administration regimens, present high cost, and are ineffective in many populations due to pathogen resistance. Moreover, beyond the pharmacological exigencies, there are other challenges concerning its parasitic nature, such as its great genetic plasticity and adaptability, enabling it to activate a battery of genes to develop resistance quickly. All these aspects demand the identification and development of new, safe, and effective chemical systems, which must not only be focused on medicinal chemistry and pharmacological aspects but also consider key aspects relative to parasite survival.In this sense, the quinolines and, in particular, 4-aminoquinoline, represent a privileged scaffold for the design of potential leishmanicidal candidates due not only to their versatility to generate highly active and selective compounds but also to their correlation with well-defined biological targets. These facts make it possible to generate safe leishmanicidal agents targeted at key aspects of parasite survival.The current review summarizes the most current examples of leishmanicidal agents based on 4-aminoquinolines focusing the analysis on two essential aspects: (i) structure–property relationship to identify the key pharmacophores and (ii) mode of action focused on key targets in parasite survival (e.g., depolarization of potential mitochondrial, accumulation into macrophage lysosome, and immunostimulation of host cells). With that information, we seek to give useful guidelines for interested researchers to face the drug discovery and development process for selective and potent leishmanicidal agents based on 4-aminoquinolines.
Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents
Authors: Du Hongtao , Ma Fang , Cao Yuanyuan , Bai Miaoyan , Gao Xinyi , Yang Ziyi , Xu Yang , Yan Yan 
Published: January 2025

IntroductionThe multi-targeted ligands (MTDL) strategy has been recognized as a promising Approach for the development of effective treatments against Alzheimer’s disease (AD), due to the presence of multiple pathological mechanisms in AD. In this study, a series of bis(7)-harmine derivatives were designed and synthesized as multifunctional drugs for the treatment of AD.MethodsThe derivatives were synthesized by chemical methods and their structure was confirmed by nuclear magnetic resonance (NMR). The Ellman’s assay was utilized to assess the inhibitory potential of derivatives against hAChE and hBuChE. The inhibitory activity of these derivatives on both hMAO-A and hMAO-B was assessed using a fluorescence-based method. The thioflavin T (Th-T) fluorescence assay was used to assess the inhibition of Aβ1−42 self-aggregation. The cytotoxicity was evaluated using the MTT assay. The Surflex-Dock program in Sybyl-X2.0 Software was employed for molecular docking.ResultsIn vitro studies revealed that numerous synthesized compounds exhibited potent inhibitory activity against hAChE, and hMAO-B (IC50 &lt; 1 μM), as well as Aβ1−42 aggregation (IC50 &lt; 20 μM). Importantly, the multitarget compounds 6d, 8c, and 8d exhibited remarkable efficacy in simultaneously mitigating Aβ-induced toxicity in SH−SY5Y cells while demonstrating minimal cytotoxicity. Furthermore, predicted ADMET results suggested that 6d, 8c, and 8d possessed favorable pharmacokinetic properties and demonstrated low toxicity levels. Additionally, molecular docking studies of 6d within the activesites of hAChE, hMAO-B, and Aβ1−42 elucidated the inhibition mechanism.Discussion and conclusionBased on these findings, it is evident that 6d, 8c, and 8d hold potential as promising multi-functional drugs for AD treatment.
Application of three-dimensional printing in the planning and execution of aortic aneurysm repair
Authors: Patel Harshank , Choi Paul , Ku Jennifer C. , Vergara Rosemary , Malgor Rafael , Patel Dhiren , Li Yong 
Published: January 2025

IntroductionThe accuracy of fenestrations in stent grafts for complex aortic aneurysms and dissections can be significantly improved using three-dimensional (3D)-printed phantoms. Standardization is enhanced by using artificial intelligence (AI) for image pre-processing before 3D printing. These methods address fallacies in centerline image analysis and manual image pre-processing. This review examines the application of 3D printing and AI in complex aortic aneurysm repair, highlighting current clinical trends.MethodsAn exhaustive literature review was performed using keywords such as “3D printing,” “Artificial intelligence,” “Thoracoabdominal aneurysm,” “Abdominal aortic aneurysm,” “Aortic arch aneurysm,” “Endovascular repair,” and “Open repair” in PubMed and Google Scholar indexes up to June 2022.ResultsThis analysis included seven studies: four focused on 3D-printed phantoms for endovascular repair of various aortic pathologies (aortic arch, thoracoabdominal aorta, juxtarenal and pararenal aorta), one on open thoracoabdominal aneurysm repair using 3D-printed models for graft construction, and two on the use of convolutional neural networks, an AI-based technology, for the pre-processing of aortic computed tomography angiography images.ConclusionThe application of 3D printing and AI-based image pre-processing in the planning of complex aortic aneurysms offers several benefits, including enhanced patient and trainee education, more accurate fenestration placement, reduced surgical time and complications, and decreased surgeon stress.
Cardiovascular outcomes in long COVID-19: a systematic review and meta-analysis
Authors: Zhang Ting , Li Zhimao , Mei Qimin , Walline Joseph Harold , Zhang Zhaocai , Liu Yecheng , Zhu Huadong , Du Bin 
Published: January 2025

IntroductionThere is growing evidence that patients with SARS-CoV-2 (The severe acute respiratory syndrome coronavirus 2) may have a variety of cardiovascular complications in the post-acute phase of COVID-19, but these manifestations have not yet been comprehensively characterized.MethodsWe performed a systematic review and meta-analysis of primary research papers which evaluated individuals at least four weeks after confirmed COVID-19 diagnosis and reported on cardiovascular disease prevalence. Systematic search conducted without language restrictions from December 1, 2019 to June 31, 2022 on PubMed, EMBASE, Web of Science, Cochrane library, ProQuest Coronavirus Research Database, COVID-19 Living Overview of the Evidence (L-OVE) subset of Episteminokos and the World Health Organization (WHO) Covid-19 databases. Study was reported according to MOOSE-lists and the PRISMA guidelines. The risk of bias was identified using the Newcastle-Ottawa Scale (NOS) for observational studies. Random-effects meta-analyses examined the pooled risk difference in the prevalence of each symptom or symptom combination in cases with confirmed SARS-coV-2 infection compared with controls.ResultsEight cohort studies were eligible, including nearly 10 million people. Long COVID-19 was associated with a higher risk of thromboembolic disorders [HR 3.12 (1.60, 6.08)], coronary heart disease [HR 1.61 (1.13, 2.31)], stroke [HR 1.71 (1.07,2.72)], arrhythmia [HR 1.60 (1.13, 2.26)], cardiomyopathy [HR 1.71 (1.12, 2.61)], myocarditis [HR 6.11 (4.17,8.94)], hypertension [HR 1.70 (1.56, 1.85)], heart failure [HR 1.72 (1.15,2.59)] and cardiogenic shock [HR 2.09 (1.53,2.86)] compared to non-COVID-19 controls. Pooled risk differences in long COVID cases compared to controls were significantly higher for cardiomyopathy [0.15% (0.06, 0.23)], deep vein thrombosis [0.45% (0.06, 0.83)] and hypertension (0.32%, (0.06, 0.58) but not for thromboembolic disorders, coronary disease, stroke, arrhythmia, cardiomyopathy, myocarditis, hypertension, heart failure or cardiogenic shock.ConclusionThe risk of cardiovascular disease increased significantly four weeks or more after recovering from acute COVID-19. Care for survivors after an acute attack of COVID-19 should include paying close attention to cardiovascular health and disease.Systematic Review RegistrationPROSPERO [CRD42022353965].