bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoskopische Unterdrucktherapie
Authors: Loske Gunnar , Müller Johannes , Schulze Wolfgang , Riefel Burkhard , Reeh Matthias , Müller Christian Theodor 
Published: October 2023

Zusammenfassung
Einleitung
Der früh postoperative Reflux (PR) kann die Anastomosenheilung nach Ivor-Lewis-Ösophagektomie (ILE) beeinträchtigen und stellt ein Risiko für Aspirationen dar. Die Anastomoseninsuffizienz ist die bedrohlichste chirurgische Komplikation.Wir stellen die protektive Methode der pre-emptiven aktiven Refluxdrainage (PARD) mit gleichzeitiger enteraler Ernährung vor. Wir berichten über unsere Erfahrungen mit dem neuen Sicherheitskonzept für die Ösophaguschirurgie an einem Patientenkollektiv von 43 Patienten.

Materialien und Methoden
Zur PARD nutzen wir eine doppellumige offenporige Foliendrainage (dOFD). Zur Herstellung der dOFD wird der gastrale Schenkel einer Trelumina Sonde (Freka®Trelumina, Fresenius) über eine Länge von 25 cm mit einer doppellagigen offenporigen Drainagefolie (Suprasorb®CNP Drainagefolie, Lohmann & Rauscher) beschichtet. Die dOFD wird nach Fertigstellung der Anastomose intraoperativ endoskopisch im Schlauchmagen eingeführt. Es wird ein kontinuierlicher Unterdruck mit einer elektronischen Pumpe angelegt (−125 mm Hg). Der PR wird permanent komplett abgesaugt, der Magen und die Anastomosenregion dekomprimiert. Gleichzeitig wird über eine integrierte Intestinalsonde ernährt. Je nach den Ergebnissen der endoskopischen Kontrolle nach 5 Tagen wird PARD entweder fortgesetzt oder beendet.

Ergebnisse
Im Beobachtungszeitraum (2017–2023) wurde PARD bei allen Patienten (n = 43) mit ILE eingesetzt. Die Heilungsrate unter PARD betrug 100 %, bei allen Anastomosen wurde eine Abheilung beobachtet. Es wurden keine zusätzlichen endoskopischen Eingriffe oder chirurgische Revisionen an den Anastomosen erforderlich. Die mediane Dauer der PARD betrug 8 Tage (Spanne 4–21). Bei 20 von 43 Patienten (47 %) sahen wir Probleme in der Anastomosenheilung, für die wir endoskopische Kriterien der Risikoanastomose definierten.

Schlussfolgerung
Unsere Ergebnisse legen nahe, dass PARD einen starken protektiven Effekt auf die Anastomosenheilung hat und das Risiko der Anastomoseninsuffizienz reduzieren kann. Die integrierte Ernährungssonde der dOFD ermöglicht simultan zur Unterdruckausübung die frühpostoperative enterale Ernährung. PARD scheint die negativen Folgen einer gestörten Anastomosenheilung zu verhindern.
Postoperative quadriceps weakness and male sex are risk factors for patellofemoral articular cartilage lesions after anatomical anterior cruciate ligament reconstruction
Authors: Murakami Ryo , Taketomi Shuji , Yamagami Ryota , Kono Kenichi , Kawaguchi Kohei , Kage Tomofumi , Arakawa Takahiro , Inui Hiroshi , Tanaka Sakae 
Published: October 2023

AbstractPurposePatellofemoral (PF) compartment cartilage lesions are a frequent problem after anterior cruciate ligament (ACL) reconstruction. This study aimed to determine the factors that influence PF cartilage lesions after anatomical ACL reconstruction.MethodsThis study enrolled a total of 114 patients who did not manifest PF compartment cartilage lesions during anatomical ACL reconstruction and underwent second‐look arthroscopy 18 months postoperatively. Arthroscopy using the International Cartilage Repair Society (ICRS) classification was used to assess cartilage lesions. The correlation between surgical findings, radiographic factors, and clinical factors and change of ICRS grade was analysed. Multivariate regression analysis was conducted to reveal the independent risk factors for PF cartilage lesions among patients’ demographic data and parameters that correlated with the change of ICRS grade in the correlation analyses.ResultsICRS grade changes in PF cartilage were significantly correlated with age, sex, quadriceps strength at 1 year postoperatively, hamstrings strength at pre‐ and 1 year postoperatively, and single leg hop test at 1 year postoperatively. However, no significant correlation was found between the time between injury and surgery, posterior tibial slope angle, pre‐ and postoperative Tegner activity scale, graft type, initial graft tension, meniscus injury, meniscus injury treatment, pre‐ and postoperative range of motion, anteroposterior laxity and preoperative quadriceps strength, and the change in ICRS grade. Multivariate regression analysis revealed male (P = 0.019) and quadriceps strength weakness at 1 year postoperatively (P = 0.009) as independent risk factors for PF cartilage lesions.ConclusionsQuadriceps strength weakness 1 year after ACL reconstruction and males were correlated with a new PF cartilage lesion after anatomical ACL reconstruction, with no significant correlation between bone‐patellar tendon‐bone autograft, initial graft tension, or extension deficit and new PF cartilage lesion. Rehabilitation that focuses on quadriceps strength after ACL reconstruction is recommended to prevent new PF cartilage lesions.Level of evidenceLevel IV.
Oral ketamine may offer a solution to the ketamine conundrum
Authors: Dutton Megan , Can Adem T. , Lagopoulos Jim , Hermens Daniel F. 
Published: October 2023

AbstractKetamine has received considerable attention for its rapid and robust antidepressant response over the past decade. Current evidence, in clinical populations, predominantly relates to parenterally administered ketamine, which is reported to produce significant undesirable side effects, with additional concerns regarding long-term safety and abuse potential. Attempts to produce a similar drug to ketamine, without the psychotomimetic side effects, have proved elusive. Orally administered ketamine has a different pharmacological profile to parentally administered ketamine, suggesting it may be a viable alternative. Emerging evidence regarding the efficacy and tolerability of oral ketamine suggests that it may be a favourable route of administration, as it appears to obtain similarly beneficial treatment effects, but without the cost and medical resources required in parenteral dosing. The pharmacological effects may be due to the active metabolite norketamine, which has been found to be at substantially higher levels via oral dosing, most likely due to first-pass clearance. Despite bioavailability and peak plasma concentrations both being lower than when administered parenterally, evidence suggests that low-dose oral ketamine is clinically effective in treating pain. This may also be due to the actions of norketamine and therefore, its relevance to the mental health context is explored in this narrative review.
Local Tumour Control Following Microwave Ablation: Protocol for the Prospective Observational CIEMAR Study
Authors: Pereira Philippe L. , Bale Reto , Fretland Åsmund Avdem , Goldberg S. Nahum , Helmberger Thomas , Meijerink Martijn R. , Orsi Franco , Stättner Stefan , Vogl Thomas , Kafkoula Anna , de Jong Niels , Zeka Bleranda , de Baère Thierry 
Published: October 2023

Abstract
Purpose
Microwave ablation (MWA) is a treatment modality for colorectal liver metastases (CRLM). While potentially curative, more information is needed on factors that contribute to long-term local tumour control. The prospective multicentre observational study CIRSE Emprint Microwave Ablation Registry aims to prospectively collect real-world technical data and clinical outcomes on patients treated with MWA in CRLM.

Methods
Eligible patients are adults with up to 9 local treatment naïve CRLM of ≤ 3 cm completely treatable with either MWA alone or MWA with resection and/or radiotherapy within 8 weeks. Data are collected, at baseline, every 3 months until 12 months, and thereafter every 6 months until the end of the study. The primary outcome measure is local tumour control. Secondary outcome measures are overall survival, (hepatic-) disease-free survival, time-to-progression untreatable by ablation, systemic therapy vacation, safety, and quality of life. Covariates related to the primary outcome measure will be assessed using a stratified log-rank test and an univariable Cox proportional hazard regression. A sample size of 500 patients with 750 lesions produces a two-sided 95% confidence interval with a precision equal to 0.057.

Results
Between September 2019 and December 2022, 500 patients have been enrolled with at least 976 treated tumours.

Conclusion
The prospective observational CIEMAR study will provide valuable insights into the real-world use of MWA, helping in the future patient selection and clarifying factors that may contribute to long-term local tumour control.
Trial Registration: NCT03775980.

Graphical Abstract
Mathematical bounds on Shannon entropy given the abundance of the ith most abundant taxon
Authors: Morrison Maike L. , Rosenberg Noah A. 
Published: October 2023

AbstractThe measurement of diversity is a central component of studies in ecology and evolution, with broad uses spanning multiple biological scales. Studies of diversity conducted in population genetics and ecology make use of analogous concepts and even employ equivalent mathematical formulas. For the Shannon entropy statistic, recent developments in the mathematics of diversity in population genetics have produced mathematical constraints on the statistic in relation to the frequency of the most frequent allele. These results have characterized the ways in which standard measures depend on the highest-frequency class in a discrete probability distribution. Here, we extend mathematical constraints on the Shannon entropy in relation to entries in specific positions in a vector of species abundances, listed in decreasing order. We illustrate the new mathematical results using abundance data from examples involving coral reefs and sponge microbiomes. The new results update the understanding of the relationship of a standard measure to the abundance vectors from which it is calculated, potentially contributing to improved interpretation of numerical measurements of biodiversity.
Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI
Authors: Sanvito Francesco , Raymond Catalina , Cho Nicholas S. , Yao Jingwen , Hagiwara Akifumi , Orpilla Joey , Liau Linda M. , Everson Richard G. , Nghiemphu Phioanh L. , Lai Albert , Prins Robert , Salamon Noriko , Cloughesy Timothy F. , Ellingson Benjamin M. 
Published: October 2023

Abstract
Objective
To determine the feasibility and biologic correlations of dynamic susceptibility contrast (DSC), dynamic contrast enhanced (DCE), and quantitative maps derived from contrast leakage effects obtained simultaneously in gliomas using dynamic spin-and-gradient-echo echoplanar imaging (dynamic SAGE-EPI) during a single contrast injection.

Materials and methods
Thirty-eight patients with enhancing brain gliomas were prospectively imaged with dynamic SAGE-EPI, which was processed to compute traditional DSC metrics (normalized relative cerebral blood flow [nrCBV], percentage of signal recovery [PSR]), DCE metrics (volume transfer constant [Ktrans], extravascular compartment [ve]), and leakage effect metrics: ΔR2,ss* (reflecting T2*-leakage effects), ΔR1,ss (reflecting T1-leakage effects), and the transverse relaxivity at tracer equilibrium (TRATE, reflecting the balance between ΔR2,ss* and ΔR1,ss). These metrics were compared between patient subgroups (treatment-naïve [TN] vs recurrent [R]) and biological features (IDH status, Ki67 expression).

Results
In IDH wild-type gliomas (IDHwt—i.e., glioblastomas), previous exposure to treatment determined lower TRATE (p = 0.002), as well as higher PSR (p = 0.006), Ktrans (p = 0.17), ΔR1,ss (p = 0.035), ve (p = 0.006), and ADC (p = 0.016). In IDH-mutant gliomas (IDHm), previous treatment determined higher Ktrans and ΔR1,ss (p = 0.026). In TN-gliomas, dynamic SAGE-EPI metrics tended to be influenced by IDH status (p ranging 0.09–0.14). TRATE values above 142 mM−1s−1 were exclusively seen in TN-IDHwt, and, in TN-gliomas, this cutoff had 89% sensitivity and 80% specificity as a predictor of Ki67 > 10%.

Conclusions
Dynamic SAGE-EPI enables simultaneous quantification of brain tumor perfusion and permeability, as well as mapping of novel metrics related to cytoarchitecture (TRATE) and blood–brain barrier disruption (ΔR1,ss), with a single contrast injection.

Clinical relevance statement
Simultaneous DSC and DCE analysis with dynamic SAGE-EPI reduces scanning time and contrast dose, respectively alleviating concerns about imaging protocol length and gadolinium adverse effects and accumulation, while providing novel leakage effect metrics reflecting blood–brain barrier disruption and tumor tissue cytoarchitecture.

Key Points
• Traditionally, perfusion and permeability imaging for brain tumors requires two separate contrast injections and acquisitions.
• Dynamic spin-and-gradient-echo echoplanar imaging enables simultaneous perfusion and permeability imaging.
• Dynamic spin-and-gradient-echo echoplanar imaging provides new image contrasts reflecting blood–brain barrier disruption and cytoarchitecture characteristics.

Graphical Abstract
Blowup Analysis of a Hysteresis Model Based Upon Singular Perturbations
Authors: Kristiansen K. U. 
Published: October 2023

AbstractIn this paper, we provide a geometric analysis of a new hysteresis model that is based upon singular perturbations. Here hysteresis refers to a type of regularization of piecewise smooth differential equations where the past of a trajectory, in a small neighborhood of the discontinuity set, determines the vector-field at present. In fact, in the limit where the neighborhood of the discontinuity vanishes, hysteresis converges in an appropriate sense to Filippov’s sliding vector-field. Recently (2022), however, Bonet and Seara showed that hysteresis, in contrast to regularization through smoothing, leads to chaos in the regularization of grazing bifurcations, even in two dimensions. The hysteresis model we analyze in the present paper—which was developed by Bonet et al in a paper from 2017 as an attempt to unify different regularizations of piecewise smooth systems—involves two singular perturbation parameters and includes a combination of slow–fast and nonsmooth effects. The description of this model is therefore—from the perspective of singular perturbation theory—challenging, even in two dimensions. Using blowup as our main technical tool, we prove existence of an invariant cylinder carrying fast dynamics in the azimuthal direction and a slow drift in the axial direction. We find that the slow drift is given by Filippov’s sliding vector-field to leading order. Moreover, in the case of grazing, we identify two important parameter regimes that relate the model to smoothing (through a saddle-node bifurcation of limit cycles) and hysteresis (through chaotic dynamics, due to a folded saddle and a novel return mechanism).
Does month of birth influence colorectal cancer prognosis?
Authors: Martín-Arévalo José , Moro-Valdezate David , Pla-Martí Vicente , García-Botello Stephanie , Moya-Marcos Pablo , Izquierdo-Moreno Ana , Pérez-Santiago Leticia , Casado-Rodrigo David , Roselló-Keränen Susana , Espí-Macías Alejandro 
Published: October 2023

Abstract
Purpose
The main aim of this study was to identify a possible association between month of birth of colorectal cancer (CRC) patients and overall survival (OS) or disease-free survival (DFS).

Methods
This observational study included all consecutive adult patients diagnosed with CRC undergoing oncological surgery from January 2005 to December 2019 with a minimum follow-up of 10 years. The outcome variables were locoregional recurrence, death due to cancer progression, OS and DFS. Non-supervised learning techniques (K-means) were conducted to identify groups of months with similar oncologic outcomes. Finally, OS and DFS were analysed using Kaplan–Meier and Cox regression tests. The model was calibrated with resampling techniques and subsequently a cross-validation was performed.

Results
A total of 2520 patients were included. Three birth month groups with different oncologic outcomes were obtained. Survival analysis showed between-group differences in OS (p < 0.001) and DFS (p = 0.03). The multivariable Cox proportional hazards model identified the clusters obtained as independent prognostic factors for OS (p < 0.001) and DFS (p = 0.031).

Conclusion
There is an association between month of birth and oncologic outcomes of CRC. Patients born in the months of January, February, June, July, October and December had better OS and DFS than those born in different months of the year.
The Limit of $$L_p$$ Voronoi Diagrams as $$p\rightarrow 0$$ is the Bounding-Box-Area Voronoi Diagram
Authors: Haverkort Herman , Klein Rolf 
Published: October 2023

AbstractWe consider the Voronoi diagram of points in the real plane when the distance between two points a and b is given by $$L_p(a-b)$$

L
p

(
a
-
b
)

where $$L_p((x,y)) = (|x|^p+|y|^p)^{1/p}.$$

L
p

(

(
x
,
y
)

)

=

(
|
x
|

p

+

|
y
|

p

)

1
/
p

.

We prove that the Voronoi diagram has a limit as p converges to zero from above or from below: it is the diagram that corresponds to the distance function $$L_*((x,y)) = |xy|$$

L

∗

(

(
x
,
y
)

)

=

|
x
y
|

. In this diagram, the bisector of two points in general position consists of a line and two branches of a hyperbola that split the plane into three faces per point. We propose to name $$L_*$$

L

∗

as defined above the geometric $$L_0$$

L
0

distance.
Future land use land cover changes in El-Fayoum governorate: a simulation study using satellite data and CA-Markov model
Authors: Atef Islam , Ahmed Wael , Abdel-Maguid Ramadan H. 
Published: October 2023

AbstractThis study aims to monitor the changes in land use land cover (LULC) in El-Fayoum governorate over time (past, present, and future) to provide current information for stakeholders involved in land use planning. The study utilized Landsat satellite images and applied the Support Vector Machine algorithm using ArcGIS Pro 2.8.3 to classify the images into four major LULC classes: water, desert, built-up, and agricultural. To evaluate the accuracy of the LULC maps, the study used kappa statistical parameters, which ranged from 0.91 to 0.94, indicating acceptable results for further analysis. To predict spatio-temporal LULC changes, the study considered biophysical and socioeconomic factors such as distance to canals, distance to roads, distance to urban areas, a digital elevation model, and slope. A combination of Multi-Criteria Evaluation, a Fuzzy Membership Function, and the Analytic Hierarchy Process were employed to develop a land cover suitability map. The Hybrid CA-Markov model of the IDRISI-TerrSet software was used to simulate LULC changes, and the accuracy of the simulation was validated using 2020 imagery data. The values gained from the kappa indices for agreement (standard) = 0.9006, kappa for lack of information (no) = 0.916, and kappa for location at grid cell level (location) = 0.9572 demonstrate that the results of the simulation of the LULC changes were deemed satisfactory. The future scenarios modeled in LULC indicate a significant change in the LULC classes over time, specifically for 2030. The change rates of agriculture, desert, built-up, and water areas in El-Fayoum in 2030 compared to 2020 are estimated to be 9.68%, − 17.58%, 133.62%, and 6.06%, respectively. These findings establish both past and future LULC trends and provide crucial data useful for planning and sustainable land use management.
Breast cancer patients’ needs and perspectives on a one-on-one peer support program: quantitative and qualitative analyses
Authors: Jansen Britt AM , Bargon Claudia A , Dinger Tessa L , van den Goor Myra , Postma Emily L , Young-Afat Danny A , Verkooijen Helena M , Doeksen Annemiek 
Published: October 2023

Abstract
Purpose
Although peer support programs as a health resource have become increasingly popular, only limited studies evaluated the added value of one-on-one peer support for breast cancer patients. This study aims to bridge the knowledge gap by focusing on two related research topics. First, we evaluated emotional well-being and (unmet) needs regarding supportive care. Second, we evaluated patients’ perspectives on their experiences after having one-on-one peer support.

Methods
A quantitative analysis was conducted to provide insight in patients’ symptoms of anxiety and depression (HADS), quality of life (EORTC-QLQ-C30), and supportive care needs (CaSUN-questionnaire). Furthermore, approximately 1 year after the implementation of a one-on-one peer support program, focus groups were conducted to evaluate patients’ perspectives regarding one-on-one peer support.

Results
Two hundred twenty-five of 537 patients diagnosed with breast cancer between 2019 and 2020 completed the questionnaires. Quantitative analysis showed increased symptoms of anxiety and depression among breast cancer patients and lower scores on all EORTC-QLQ-C30 domains compared to the Dutch normative population. Of all patients, 27.6% (95%CI = 0.22–0.34) reported to have unmet needs regarding emotional support and 23.1% (95%CI = 0.18–0.29) reported an unmet need to talk to someone who has experienced breast cancer. For the qualitative analysis, 19 breast cancer patients who were taking part in the one-on-one peer support program participated in three focus groups. Benefits, limitations, and wishes regarding the one-on-one peer support program were discussed.

Conclusion
Breast cancer patients showed increased anxiety and depression and lower quality of life, physical, role, emotional, cognitive, and social functioning compared to the Dutch normative population. Almost one-third of breast cancer patients reported unmet needs regarding emotional support and a desire to talk to other breast cancer patients. These (unmet) needs can successfully be met by providing a low-threshold one-on-one peer support program.
Predicted novel hypertrehalosaemic peptides of cockroaches are verified by mass spectrometry
Authors: Marco Heather G. , König Simone , Gäde Gerd 
Published: October 2023

AbstractSmall neuropeptides from the corpora cardiaca are responsible in cockroaches for the mobilisation of trehalose from the fat body into the haemolymph. Such hypertrehalosaemic hormones (HrTHs) belong to the large family of insect adipokinetic hormones (AKHs); a few HrTHs were previously sequenced from cockroaches, and from genomic and/or transcriptomic information one may predict the genes encoding HrTHs from more species. Definite elucidation of the primary structure of the mature peptide with putative modifications needs analytical chemical methods. In the current study, we use high-resolution mass spectrometry coupled with liquid chromatography to identify unequivocally the HrTHs of 13 cockroach species. Either genomic/transcriptomic information was available for most of the species examined, or from related species. We confirm predicted novel sequences and find hydroxyproline modification for the majority of the peptides. The novel decapeptides are structurally close to Bladi-HrTH, which is found in all seven of the investigated blaberid subfamilies. Bladi-HrTH and all the novel peptides elicit a hypertrehalosaemic response in Periplaneta americana, a blattid cockroach.