bluuebunny/crossref_metadata_2025_split huggingface dataset:
User evaluation and feasibility test of an app designed for smoking cessation in Italian people who smoke: preliminary findings from an uncontrolled pre-test post-test open study
Authors: Caponnetto Pasquale , Casu Mirko , Crane David , Ross Louise , Quattropani Maria Catena , Polosa Riccardo 
Published: November 2023

Abstract
Background
mHealth is a public health practice that exploits the use of mobile devices, including smartphone applications. We will describe an uncontrolled pre-test post-test open pilot study concerning the feasibility evaluation of a smartphone App designed to help in smoking cessation. The aim of this study is to evaluate the feasibility of a smartphone app as a tool for smoking cessation. This study is necessary to the literature because smoking is a major public health concern and has been linked to various health issues such as cardiovascular disease, respiratory disease, and cancer. While there are several smoking cessation interventions available, the use of mobile devices to aid in smoking cessation is a relatively new and innovative approach that requires further investigation.

Methods
The App “Smoke Free” was configured on the devices of N = 30 participants who smoked combustible cigarette, 13 males and 17 females aged 18 to 55 years, with the indications to use it for 90 days, describe their experience, suggest new features, and report any critical aspect. The study consisted of an initial screening visit to select participants that reflected the inclusion criteria and 4 study visits: a baseline visit, two follow-up visits, and one final visit. We used descriptive stats to summarize results. Repeated measures ANOVA and Wilcoxon test were used to test differences in smoking consumption, self-reported craving, and measured eCO level. Statistical software Jamovi was used for analysis. Interviews were conducted via phone or in-person and analyzed using qualitative description principles.

Results
Participants evaluated the app as having good aesthetic appeal and user-friendliness but being moderately useful, despite some quitting or reducing their smoking behavior. To improve it, participants have proposed features such as more notifications, social network integration, and damage caused by smoking to the body over time for future app updates.

Conclusions
The application was moderately useful with good feasibility, with several suggestions for future updates that could improve its effectiveness.
Esophagectomy for esophageal stricture with systemic sclerosis: a case report
Authors: Ebata Yuho , Kimura Yasue , Nonaka Kentaro , Nambara Sho , Hu Qingjiang , Nakanishi Ryota , Nakanoko Tomonori , Ota Mitsuhiko , Oki Eiji , Yoshizumi Tomoharu 
Published: November 2023

Abstract
Background
Systemic sclerosis (SSc) is an autoimmune disease characterized by frequent esophageal involvement. However, there are few reports on esophagectomy for esophageal strictures associated with SSc. Herein, we present a case of successful treatment of an esophageal stricture associated with SSc through subtotal esophagectomy.

Case presentation
A 53-year-old female patient was diagnosed with SSc, interstitial pneumonia, and gastroesophageal reflux disease (GERD). The patient developed an esophageal ulcer and benign stricture that required a subtotal esophagectomy 10 years after the diagnosis. Histopathological findings revealed thinning of the muscle layer, a characteristic feature of SSc. The patient was free of dysphagia or regurgitation.

Conclusions
An esophagectomy is a valuable option for treating esophageal strictures in SSc. Therefore, surgical approaches should be established for patients with SSc.
Are We Jumping to the Wrong Conclusions? Longer Jumps and More Hops in Female Football Players Who Went on to Sustain a Primary or Secondary ACL Injury Compared to Those Who Did Not
Authors: Fältström Anne , Kvist Joanna , Hägglund Martin 
Published: November 2023

Abstract
Background
Different functional performance tests are used to assess patients in the clinic and before return to sport (RTS), where the rehabilitation goal is to reach good strength and jumping ability. A limb symmetry index of ≥ 90% is a common target in rehabilitation before RTS. The aim of this short communication is to use data from our 2-year prospective cohort study on female football players, either with or without an anterior cruciate ligament (ACL) reconstruction, to discuss whether hop performance in 3 commonly used hop tests can inform safe football participation, that is, with a low risk for ACL injury or reinjury.

Method
At baseline, 117 active female football players (mean age ± standard deviation, 20 ± 2 years) were included 19 ± 9 months after ACL reconstruction as well as 119 matched female knee-healthy players (age 19 ± 3 years). All players performed a single hop for distance test, 5-jump test and side hop test at baseline and were then prospectively followed for 2 years. Twenty-eight (24%) players sustained a second ACL injury and 8 (7%) sustained a primary ACL injury.

Results
Longer jumps in the 5-jump test (922 cm vs. 865 cm, Cohen’s d =  − 0.60) and more hops in the side hop test for both limbs (41–42 hops vs. 33–36 hops, d =  − 0.43 to − 0.60) were seen in players who sustained a second ACL injury compared with those who did not. Longer jumps in the single hop for distance test (both limbs) (139–140 cm vs. 124–125 cm, d =  − 0.38 to − 0.44), in the 5-jump test (975 cm vs. 903 cm, d = −0.42) and more hops in the side hop test (both limbs) (48–49 hops vs. 37–38 hops, d =  − 0.38 to − 0.47) were seen in players who sustained a primary ACL injury compared with those who did not.

Conclusions
The average hop performance, i.e. longer jumps or more hops, was greater in players who went on to sustain a primary or secondary ACL injury compared to those who did not over a two-year follow-up period. Even though hop tests are not used in isolation to evaluate readiness to RTS, their interpretation needs consideration in the decision-making process of returning to pivoting sports.
Dietary phytochemical index and psychological disorders in a large sample of Iranian adults: a population-based study
Authors: Darabi Zahra , Vasmehjani Aazam Ahmadi , Salehi-Abargouei Amin , Mirzaei Masoud , Hosseinzadeh Mahdieh 
Published: November 2023

Abstract
Background
Intake of plant foods and phytochemicals can decrease the odds of mental health.

Aim
The aim of study is to investigate the association between Dietary Phytochemical Index (DPI) with symptoms of depression, anxiety and stress in a large sample of Iranian adults.

Methods
In this cross-sectional study, a total of 7385 adults aged 20–50 years old were provided from the recruitment phase of Yazd Health Study, a population-based cohort research on Iranian adults. Food intakes were assessed via a validated and reliable food frequency questionnaire. Symptoms of depression, anxiety and stress were assessed using a validated Depression, Anxiety and Stress Scales questionnaire with 21-items. DPI was calculated by the percent of daily energy intake taken from phytochemical-rich foods.

Results
After adjustment for potential confounders, normal weight subjects in the highest tertile of DPI had lower odds of depression (OR 0.65; 95% CI 0.44–0.97) and anxiety symptoms (OR 0.65; 95% CI 0.45–0.93) compared with those in the lowest tertile. However, the apparent association was not found between depression, anxiety and stress in overweight and obese subjects.

Conclusion
We found a significant association between DPI and mental health in normal weight adults. Prospective studies are required to approve these conclusions.
Proceedings of international symposium of trends in radiopharmaceuticals 2023 (ISTR-2023)
Authors: Jalilian Amirreza , Decristoforo Clemens , Denecke Melissa , Elsinga Philip H. , Hoehr Cornelia , Korde Aruna , Lapi Suzanne E. , Scott Peter J. H. 
Published: November 2023

AbstractThe International Atomic Energy Agency (IAEA) held the 3rd International Symposium on Trends in Radiopharmaceuticals, (ISTR-2023) at IAEA Headquarters in Vienna, Austria, during the week of 16–21 April 2023. This procedural paper summarizes highlights from symposium presentations, posters, panel discussions and satellite meetings, and provides additional resources that may be useful to researchers working with diagnostic and therapeutic radiopharmaceuticals in the academic, government and industry setting amongst IAEA Member States and beyond. More than 550 participants in person from 88 Member States attended the ISTR-2023. Over 360 abstracts were presented from all over the world by a diverse group of global scientists working with radiopharmaceuticals. Given this group of international radiochemists is unique to ISTR (IAEA funding enabled many to attend), there was an invaluable wealth of knowledge on the global state of the radiopharmaceutical sciences present at the meeting. The intent of this Proceedings paper is to share this snapshot from our international colleagues with the broader radiopharmaceutical sciences community by highlighting presentations from the conference on the following topics: Isotope Production and Radiochemistry, Industrial Insights, Regional Trends, Training and Education, Women in the Radiopharmaceutical Sciences, and Future Perspectives and New Initiatives. The authors of this paper are employees of IAEA, members of the ISTR-2023 Organizing Committee and/or members of the EJNMMI Radiopharmacy and Chemistry Editorial Board who attended ISTR-2023. Overall, ISTR-2023 fostered the successful exchange of scientific ideas around every aspect of the radiopharmaceutical sciences. It was well attended by a diverse mix of radiopharmaceutical scientists from all over the world, and the oral and poster presentations provided a valuable update on the current state-of-the-art of the field amongst IAEA Member States. Presentations as well as networking amongst the attendees resulted in extensive knowledge transfer amongst the various stakeholders representing 88 IAEA Member States. This was considered particularly valuable for attendees from Member States where nuclear medicine and the radiopharmaceutical sciences are still relatively new. Since the goal is for the symposium series to be held every four years; the next one is anticipated to take place in 2027.
Performance of the FACT-GOG-Ntx to assess chemotherapy-induced peripheral neuropathy (CIPN) in pediatric high risk Hodgkin lymphoma: report from the Children’s Oncology Group AHOD 1331 study
Authors: Parsons Susan K. , Rodday Angie Mae , Pei Qinglin , Keller Frank G. , Wu Yue , Henderson Tara O. , Cella David , Kelly Kara M. , Castellino Sharon M. 
Published: November 2023

Abstract
Background
Chemotherapy-induced peripheral neuropathy (CIPN) is an under-recognized complication of several chemotherapy agents used as part of curative-intent therapy for Hodgkin Lymphoma (HL). In the absence of validated self- or proxy-report measures for children and adolescents, CIPN reporting has relied on clinician rating, with grading scales often restricted to severe manifestations. In a proof-of-concept study, we assessed the feasibility and psychometric performance of the Functional Assessment of Cancer Therapy-Gynecologic Oncology Group-Neurotoxicity (FACT-GOG-Ntx), a unidimensional CIPN symptom scale widely used adults with CIPN, in pediatric HL at risk for CIPN.

Methods
Youth (11+ years) and parents of all children (5–17.9 years) with newly diagnosed high-risk HL enrolled on Children’s Oncology Group AHOD1331 (NCT02166463) were invited to complete the FACT-GOG-Ntx and a health-related quality of life (HRQL) measure at pre-treatment (Time 1), and during cycles 2 (Time 2) and 5 (Time 3) of chemotherapy during the first half of study accrual. Clinical grading of CIPN by providers was also assessed using the Balis Pediatric Neuropathy Scale. We evaluated Cronbach’s alpha, construct validity, and agreement between raters. Change in FACT-GOG-Ntx scores over time was assessed using a repeated measures model.

Results
306 patients had at least one completed FACT-GOG-Ntx with time-specific completion rates of > 90% for both raters. Cronbach’s alpha was > 0.7 for youth and parent-proxy report at all time points. Correlations between FACT-GOG-Ntx and HRQL scores were moderate (0.41–0.48) for youth and parent-proxy raters across all times. Youth and parent-proxy raters both reported worse FACT-GOG-Ntx scores at Time 3 for those who had clinically-reported CIPN compared to those who did not. Agreement between raters was moderate to high. Compared to baseline scores, those at Time 3 were significantly lower for youth (β = − 2.83, p < 0.001) and parent-proxy raters (β = − 1.99, p < 0.001).

Conclusions
High completion rates at all time points indicated feasibility of eliciting youth and parent report. Psychometric performance of the FACT-GOG-Ntx revealed acceptable reliability, evidence of validity, and strong inter-rater agreement, supporting the use of this self- or proxy-reported measure of CIPN in youth with high-risk HL exposed to tubulin inhibitors, as part of a Phase 3 clinical trial.
Clinical trial information: Clinical Trials Registry, NCT02166463. Registered 18 June 2014, https://clinicaltrials.gov/ct2/show/study/NCT02166463
A novel technique for safe blind percutaneous tracheotomy: retrospective case-series study on three hundred eighty-six patients
Authors: Beshay Bassem N. , Elbardan Islam M. , Moustafa Moustafa A. , Shehab Ahmed S. 
Published: November 2023

Abstract
Background
Griggs’ technique with assisting tools for bedside percutaneous tracheotomy (PDT) is safe and fast and carries few complications in expert hands. Assisting tools are not routinely available in many ICUs. The study aims to evaluate the impact of a novel technique for blind percutaneous tracheotomy on success rate, duration of the procedure, and rate of complications. This retrospective case-series study was conducted in the different intensive care units in Alexandria University Hospitals. Three hundred eighty-six patients were recruited from 1 January 2018 to 31 December 2021. After skin incision and blunt pre-tracheal dissection, a needle was inserted to access the airway, transfixing the endotracheal tube (ETT). A change in the alignment of the needle tip inside the trachea from caudal to cranial accompanied the withdrawal of the ETT off the trachea. In situ caudal needle redirection for subsequent guidewire passage distally into the trachea was done. The rest of the procedure was continued as Griggs’ technique.

Results
The success rate was 100%. The procedure duration (in seconds) was 125.73±19.52. No procedure-related deaths or major intra-operative complications were encountered. Only three patients developed pneumothorax and subcutaneous emphysema, managed by intercostal tube insertion.

Conclusions
The novel technique for blind percutaneous tracheotomy was successful with no significant procedure-related complications. The duration of the procedure was comparable to the literature.
Labile graphitic monolayers as a partition phase for containment of organic chemicals by graphene-based nanomaterials
Authors: Chen Jui-Te , Hou Wen-Che , Lin Tsair-Fuh , Chiou Cary T. 
Published: November 2023

AbstractGraphene-based nanomaterials (GBNMs) (e.g., graphene oxides and carbon nanotubes) display superior electronic and thermal conductivities and varying abilities to contain organic substances. This study sheds light to the idea that GBNMs behave as a dual sorbent, rather than a sole adsorbent, to extract nonionic organic solutes from water by both (competitive) adsorption and (noncompetitive) partition because of the solute interactions with various GBNM nanostructures formed by atomically-thin graphitic monolayers. Essential solute-sorption data with three model GBNMs from this research and similar data from the literature lead to a coherent view that labile graphitic monolayers in GBNMs undergo a liquid-like motion at room temperature to retain nonionic organic solutes by partition while structurally rigid graphitic clusters behave as adsorbents. Because the partition is noncompetitive, the GBNMs possessing high levels of labile graphene layers, as reflected by high BET surface areas, are capable of sequestering vastly higher levels of multiple organic solutes (especially, those of liquids) than conventional adsorbents, e.g., activated carbon (AC). Moreover, the postulated dual functionality of GBNMs makes sense of many otherwise puzzling phenomena, such as the highly concentration-dependent solute competitive effect with certain GBNMs and highly variable “adsorbed capacities” per unit surface area for different organic solutes with a GBNM versus those by a conventional adsorbent (e.g., graphite or AC).
Graphical Abstract
Life cycle assessment of a 33.7 MW solar photovoltaic power plant in the context of a developing country
Authors: Badza Kodami , Soro Y. M. , Sawadogo Marie 
Published: November 2023

AbstractThis work aims to determine the Energy Payback Time (EPBT) of a 33.7 MWp grid-connected photovoltaic (PV) power plant in Zagtouli (Burkina Faso) and assess its environmental impacts using the life cycle assessment tool according to ISO 14040 and 14044 standards. A “cradle to grave” approach was used, considering 1 kWh of electricity produced and injected into the national grid over 25 years as a functional unit. In addition to the baseline scenario, the other simulated scenarios combining three variables, module technology (mono c-Si, poly c-Si, and CdTe), type of mounting structure (aluminum and steel), and end-of-life treatments (landfill and recycling) were considered. SimaPro 9.4 software and the ReCiPe 2016 Midpoint (H) evaluation method were used for the calculations considering four environmental indicators. A sensitivity analysis of the change in the electricity mix was also performed. Results showed that the EPBT of the scenarios varies between 1.47 and 1.95 years, with the shortest and longest corresponding to scenarios 4 (CdTe modules, steel mounting structure, and recycling as end-of-life treatment) and scenario 3 (mono c-Si modules, aluminum mounting structure, and recycling as end-of-life treatment), respectively. All the EPBT scenarios studied can be considered acceptable given the long lifetime of PV systems (25 years). The following environmental impact results were obtained: climate change 37–48 CO2-eq kWh-1, freshwater ecotoxicity 4–11 g 1,4-DCB kWh-1, mineral resource scarcity 0.4–0.7 g Cu-eq kWh-1 and 11–13 g oil-eq kWh-1 for fossil resource scarcity. Scenario 3 (mono c-Si modules, aluminum mounting structure, and recycling as end-of-life treatment) dominates all environmental indicators studied except freshwater ecotoxicity, which is dominated by scenario 4 (CdTe modules, steel mounting structure, and recycling as end-of-life treatment). The sensitivity analysis showed that the change in the electricity mix could reduce around 30% the EPBT, climate change, and fossil resource scarcity. Considering the environmental indicators studied, using CdTe modules manufactured in a country with a less carbon-intensive electricity mix, using galvanized steel as the mounting structure, and completely recycling components at the end of their lifetime is the most environmentally friendly scenario. However, particular attention needs to be paid to the land occupation that this plant could generate.
Development of stability-indicating HPLC method for quantification of pharmacopeia impurities of Zuclopenthixol and characterization of its stress degradation products by LCMS/MS
Authors: Sesharamsingh Bondili , Kumar J. Suresh , Viswanath I. V. Kasi , Rao Gattupalli Subhakara , Anna Venkateswara Rao 
Published: November 2023

AbstractBackgroundThe present study focused to develop a simple and sensitive HPLC method for resolution and estimation process-related impurities of zuclopenthixol and further assessment of forced degradation behavior of zuclopenthixol.ResultsThe chromatographic separation of drug substance, process-related impurities and its degradation products (DPs) was achieved on KNAUER C18 (250 mm × 4.6 mm, 5µ id) column at that was maintained at 35 °C temperature using 0.1 M sodium acetate buffer at pH 4.3 and methanol in 20:80 (v/v) as mobile phase A, 0.1% formic acid and acetonitrile in 75:25 (v/v) as mobile phase B. Equal volume of mobile phase A and B was pumped in isocratic elution at 0.8 mL/min. Detection wavelength was selected as 257 nm. In the proposed conditions, zuclopenthixol is identified at 6.91 and 1.91 min and 2.89 min, respectively, for impurity B and A min with acceptable system suitability and specificity. The method produces LOD at 0.009 for impurities with calibration range of 30–180 µg/mL for zuclopenthixol and 0.03–0.18 µg/mL for impurities. The other validation parameters were notices to be with in the acceptable levels for zuclopenthixol and its impurities. The drug was exposed to different stressed conditions (acid, base, peroxide, thermal and UV light) according to ICH Q1A (R2) guidelines. The DPs formed during the stress study were identified and characterized by LCMS/MS in ESI positive mode.ConclusionThe analysis involved a comparison of collision-induced dissociation mass spectrometry data between the degradation products and zuclopenthixol. As a result, potential structures for six degradation compounds were suggested. The results from additional validation studies were similarly pleasing and demonstrated their suitability for the routine analysis of zuclopenthixol and its associated impurities in both bulk drug and pharmaceutical dosage forms. Additionally, these findings can be extended to assess the mechanism of stress degradation in zuclopenthixol.
Time to Benefit of Surgery vs Targeted Medical Therapy for Patients With Primary Aldosteronism: A Meta-analysis
Authors: Samnani Sunil , Cenzer Irena , Kline Gregory A , Lee Sei J , Hundemer Gregory L , McClurg Caitlin , Pasieka Janice L , Boscardin W John , Ronksley Paul E , Leung Alexander A 
Published: November 2023

Abstract

Context
Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, but the comparative outcomes of targeted treatment remain unclear.

Objective
To compare the clinical outcomes in patients treated for primary aldosteronism over time.

Methods
Medline and EMBASE were searched. Original studies reporting the incidence of mortality, major adverse cardiovascular outcomes (MACE), progression to chronic kidney disease, or diabetes following adrenalectomy vs medical therapy were selected. Two reviewers independently abstracted data and assessed study quality. Standard meta-analyses were conducted using random-effects models to estimate relative differences. Time to benefit meta-analyses were conducted by fitting Weibull survival curves to estimate absolute risk differences and pooled using random-effects models.

Results
15 541 patients (16 studies) with PA were included. Surgery was consistently associated with an overall lower risk of death (hazard ratio [HR] 0.34, 95% CI 0.22-0.54) and MACE (HR 0.55, 95% CI 0.36-0.84) compared with medical therapy. Surgery was associated with a significantly lower risk of hospitalization for heart failure (HR 0.48 95% CI 0.34-0.70) and progression to chronic kidney disease (HR 0.62 95% CI 0.39-0.98), and nonsignificant reductions in myocardial infarction and stroke. In absolute terms, 200 patients would need to be treated with surgery instead of medical therapy to prevent 1 death after 12.3 (95% CI 3.1-48.7) months.

Conclusion
Surgery is associated with lower all-cause mortality and MACE than medical therapy for PA. For most patients, the long-term surgical benefits outweigh the short-term perioperative risks.