bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of cluster thinning and harvest date on berry volatile composition and sensory profile of <i>Vitis</i> sp. Seyval blanc and Vandal-Cliche
Authors: Nicolle Paméla , Barthe Catherine , Dorais Martine , Dubé Gaëlle , Angers Paul , Pedneault Karine 
Published: November 2023

Northern conditions are challenging for grape and wine producers. To cope with these challenges, the use of early ripening interspecific hybrid Vitis sp., such as Seyval blanc and Vandal-Cliche, is often preferred to traditional V. vinifera. However, knowledge about cultural practices suitable for interspecific hybrid varieties are still scarce, especially regarding their impact on profiles of volatile compounds and the sensory perception of berries. In this study, the impact of cluster thinning and harvest date on grapevine physiology, must chemical composition and berry sensory attributes of Seyval blanc and Vandal-Cliche was investigated. Three crop loads (100 %, 70 % and 40 % crop) and three harvest dates corresponding to pre-maturity, maturity, and post-maturity were assessed in 2012 and 2013. Cluster thinning significantly decreased the yield of Vandal-Cliche, but not of Seyval blanc, for which it instead improved fruit set without affecting yield. The impact of cluster thinning on must chemical composition was limited for both cultivars, although some significant changes were observed, especially in the cool season of 2013. Clear variations during ripening, in terms of technological parameters and aroma characteristics, were observed depending on the cultivars and the seasons. In Seyval blanc, C6-alcohols and C13-norisoprenoids decreased during ripening, while C6-aldehydes and linalool increased. In Vandal-Cliche, berries from the first and the last sampling dates of the warm season of 2012 showed the highest levels of C13-norisoprenoids, whereas berries from the last sampling date in the cold season of 2013 showed the highest levels of terpenes, C13-norisoprenoids and ethyl esters. Despite its limited impact on fruit chemical composition, cluster thinning significantly impacted the sensory perception of Vandal-Cliche berries in both years. Cluster-thinned berries had softer skin, sweeter and less acidic pulp, and fruitier skin and pulp aroma. Skin softness allowed excellent discrimination of the maturity of both cultivars during the two study years, suggesting that this descriptor could be a suitable maturity marker for these interspecific hybrid varieties. In summary, cluster thinning proves beneficial for enhancing fruit set in Seyval Blanc in a northern climate; however, its influence on fruit quality is minimal for both cultivars.
Employee Cardiometabolic Risk Following a Cluster-Randomized Workplace Intervention From the Work, Family and Health Network, 2009–2013
Authors: Berkman Lisa F. , Kelly Erin L. , Hammer Leslie B. , Mierzwa Frank , Bodner Todd , McNamara Tay , Koga Hayami K. , Lee Soomi , Marino Miguel , Klein Laura C. , McDade Thomas W. , Hanson Ginger , Moen Phyllis , Buxton Orfeu M. 
Published: November 2023

Objectives. To examine whether workplace interventions to increase workplace flexibility and supervisor support and decrease work–family conflict can reduce cardiometabolic risk. Methods. We randomly assigned employees from information technology (n = 555) and long-term care (n = 973) industries in the United States to the Work, Family and Health Network intervention or usual practice (we collected the data 2009–2013). We calculated a validated cardiometabolic risk score (CRS) based on resting blood pressure, HbA1c (glycated hemoglobin), HDL (high-density lipoprotein) and total cholesterol, height and weight (body mass index), and tobacco consumption. We compared changes in baseline CRS to 12-month follow-up. Results. There was no significant main effect on CRS associated with the intervention in either industry. However, significant interaction effects revealed that the intervention improved CRS at the 12-month follow-up among intervention participants in both industries with a higher baseline CRS. Age also moderated intervention effects: older employees had significantly larger reductions in CRS at 12 months than did younger employees. Conclusions. The intervention benefited employee health by reducing CRS equivalent to 5 to 10 years of age-related changes for those with a higher baseline CRS and for older employees. Trial Registration. ClinicalTrials.gov Identifier: NCT02050204. (Am J Public Health. 2023;113(12):1322–1331. https://doi.org/10.2105/AJPH.2023.307413 )
3D Plotting of Gold Solubility and Gold Fineness: Quantitative Analysis of Ore-Forming Conditions in Hydrothermal Gold Deposits
Authors: Liang Yi , Ge Hangfei , Pei Qiuming , Huang Haonan , Hoshino Kenichi 
Published: November 2023

Abstract
The 3D plotting of gold solubility and gold fineness aims to illustrate how to quantify their correlations with ore-forming conditions in hydrothermal gold deposits. The thermodynamic calculation of the Au-Ag solid solutions in Mathematica and the 3D plotting in MATLAB are used to build isopleths of gold solubility and gold fineness at different temperatures (200℃, 400℃), pressures (0.1, 5 kbar), salinities (1, 40 wt% NaCl eq.), and sulfur concentrations (0.01, 0.5 mol/kg). The plot indicates that the ore-forming conditions have different correlations with gold solubility and gold fineness. Average rates of change for the correlations are quantified, showing distinct values in the four pH-logfO2 fields of (I) HSO4−, (II) SO42−, (III) H2S, and (IV) HS−, where dominant gold and silver complexes have different dependencies on the conditions. The quantification of the plots illustrates that a decrease in gold solubility by one order of magnitude is possibly caused by a decrease in temperature of ≥40℃, the salinity of ≥9.6 wt% NaCl eq. or sulfur concentration of ≥0.14 mol/kg, or an increase in pressure of ≥3 kbar, while a decrease in gold fineness by 100 units is possibly caused by a decrease in temperature of ≥14 ℃, pressure of ≥1.4 kbar, or salinity of ≥4 wt% NaCl eq., or an increase in sulfur concentration of ≥0.07 mol/kg. Quantification results suggest that a sharp decrease in temperature may result in large-scale gold mineralization and a great variation in gold fineness. In addition, the quantification reveals that the correlation between gold solubility and gold fineness can be expressed by a function, providing a rapid method for 3D plotting.
Identification of inulin-responsive bacteria in the gut microbiota via multi-modal activity-based sorting
Authors: Berry David , Riva Alessandra , Rasoulimehrabani Hamid , Cruz-Rubio José Manuel , Schnorr Stephanie , von Baeckmann Cornelia , Inan Deniz , Nikolov Georgi , Herbold Craig , Hausmann Bela , Pjevac Petra , Schintlmeister Arno , Spittler Andreas , Palatinszky Marton , Kadunic Aida , Hieger Norbert , Favero Giorgia Del , von Bergen Martin , Jehmlich Nico , Watzka Margarete , Lee Kang Soo , Wiesenbauer Julia , Khadem Sanaz , Viernstein Helmut , Stocker Roman , Wagner Michael , Kaiser Christina , Richter Andreas , Kleitz Freddy 
Published: November 2023

Abstract
Prebiotics are defined as non-digestible dietary components that promote the growth of beneficial gut microorganisms. In many cases, however, this capability is not systematically evaluated. Here, we develop a methodology for determining prebiotic-responsive bacteria using the popular dietary supplement inulin. We first identify microbes with a capacity to bind inulin using mesoporous silica nanoparticles functionalized with inulin. 16S rRNA gene amplicon sequencing of sorted cells revealed that the ability to bind inulin was widespread in the microbiota. We further evaluate which taxa are metabolically stimulated by inulin and find that diverse taxa from the phyla Firmicutes and Actinobacteria respond to inulin, and several isolates of these taxa can degrade inulin. Incubation with another prebiotic, xylooligosaccharides (XOS), in contrast, shows a more robust bifidogenic effect. Interestingly, the Coriobacteriia Eggerthella lenta and Gordonibacter urolithinfaciens are indirectly stimulated by the inulin degradation process, expanding our knowledge of inulin-responsive bacteria.
Age Prevalence and Management of Breast Fibroadenoma at a Nigerian Tertiary Hospital: a Five-year (2016-2020) Analytical Review
Authors: Ogochukwu Anaziah Grace 
Published: November 2023

Abstract
Background: Fibroadenomas are one of the most common benign tumors of the breast in women between 18-39 years of age. In the adolescent population, the overall incidence of fibroadenoma is 2.2% and accounts for 68% of all breast masses. It feels like a smooth lump in the breast. It is painless and moves easily when touched.
Method: Following the consecutive percutaneous needle or excision surgical biopsy all breast masses were grossed and processed according to the standard histological tissue processing techniques. 241 of 1038 breast tissues were diagnosed of fibroadenoma in the Nigerian tertiary hospital.
Result: Out of 82% of histology specimen received for the period of five years, 13% were excised breast masses and 5% was confirmed positive for fibroadenoma. Out of this 5% of positive cases from 2016 to 2020, there was a slight and irregular interval of 1-4% increase each year. The prevalence of fibroadenoma was mostly seen in youths of ages 18-39 years having 75%, followed by adolescence of ages <18 years with 22% and lastly older adults of ages 40-59 years with 3%. The cause of this prevalence is not confirmed but with the current view of fibroadenoma cases in this study it can be predicted that there might be subsequent increase of cases in of this specific age group in the future.
The slight annual increase indicates that breast fibroadenoma across the varying age groups underwent varying degrees of somatic mutations and harbored mutations in the exon (exon 2) of the mediator complex subunit 12 (MED12) gene of the stromal cells of the breast which led to the excessive proliferation.
Conclusion: The data presented showed high prevalence of fibroadenoma cases in ages 18-39 annually which indicates that these individuals in this age group experienced rapid instability of the estrogen or progesterone hormone either due to childbearing, abortion, or genetic hormonal abnormalities. This suggests that there might be increased rates of abortion occurring among this age group in Nigeria or lack of proper postnatal care in Nigeria tertiary hospitals. More clinical investigations need to be carried out to confirm these suspected reasons in Nigeria.
Potential Therapeutic Targets for Leishmaniasis: Modulating Cytokine Production and ECM Organization
Authors: Momeni Kavoos , Ghorbian Saeid , Ahmadpour Ehsan , Sharifi Rasoul , Berenji Fariba 
Published: November 2023

Abstract
Cutaneous leishmaniasis (CL) is a parasitic disease that causes skin ulcers, which often receive inadequate treatment. The pathophysiological mechanisms underlying these wounds are complex and not well understood. In this study, we performed co-expression network analyses on RNAseq data from skin biopsies of CL and healthy samples and identified 6,096 differentially expressed genes, with 456 proposed causative biomarkers of skin ulcers in CL. We grouped these genes based on functional analysis into three important operational groups related to wound healing. Our results suggest that the genes responsible for producing tissue-damaging cytokines play a significant role in tissue damage and wound healing prevention. Additionally, we identified changes in the expression of genes involved in extracellular matrix (ECM) organization and matrix metalloproteinase (MMP) activity, which can disrupt ECM activity and fail to heal the wounds. Targeting these genes involved in ECM organization and MMP activity could potentially help to restore normal tissue repair processes and reduce tissue damage during Leishmania infection. However, further research is needed to fully understand the roles of these genes in the disease and their potential as therapeutic targets. The results of this study provide valuable insights into the underlying pathophysiological mechanisms of CL-induced skin ulcers and can help develop better treatment strategies.
A retrospective study of a national survey of persons with severe mental illness living in rehabilitation care settings: Risks for re-hospitalization
Authors: Nisim Uzi , Zlotnick Cheryl , Roe David , Gelkopf Marc , Shadmi Efrat 
Published: November 2023

Abstract
Background
The high rates of psychiatric re-hospitalizations (also termed “revolving door”) presents a “wicked problem” which requires a systematic and holistic approach to its resolution. Israel’s mental-health rehabilitation law provides a comprehensive set of services intended to support the ability of persons with Severe Mental Illness (SMI) to rely on community rather than in-patient facilities for their ongoing care needs. Guided by the Health Behavior Model (HBM), we examined the relationship between psychiatric re-hospitalizations and the three HBM factors (predisposing factor: socio-demographic characteristics and health beliefs; enabling factor: personal and social/vocational relationships facilitated by rehabilitation interventions and services; and need factor: outcomes including symptoms, and mental health and functional status) among persons with SMI receiving rehabilitation services.
Methods
Logistic regression models were used to measure the association between re-hospitalization within a year and variables comprising the three HBM factors on the sample of consumers utilizing psychiatric services (n = 7,165). Model discrimination (area under the curve or AUC) was calculated for each factor separately and for all three factors combined.
Results
A total of 846 (11.8%) consumers were hospitalized within a year after the study began. Although multivariable analyses showed significant associations between re-hospitalization and all three HBM factors, the magnitude of the AUC differed: 0.61 (CI = 0.59–0.64), 0.56 (CI = 0.54–0.58), 0.78 (CI = 0.77–0.80) and 0.78 (CI = 0.76–0.80) for predisposing, enabling, need and the full three-factor HBM, respectively.
Conclusion
Findings revealed that among the three HBM factors, the need factor best predicted re-hospitalization. The enabling factor, comprised of: personal relationships and social/vocational activities facilitated by interventions and services, which represents many of the key goals of psychiatric rehabilitation, had the weakest association with reduced rates of re-hospitalization. Possible explanations may be inaccurate assessments of consumers' personal relationships and social/vocational activities by the mental healthcare professionals, problematic provider-consumer communication on the consumers' involvement in social/vocational activities, or ineffective methods of facilitating consumer participation in these activities. Clearly to reduce the wicked “revolving-door” phenomenon, there is a need for targeted interventions and a review of current psychiatric rehabilitation policies to promote the comprehensive integration of community rehabilitation services by decreasing the fragmentation of care, facilitating continuity of care with other healthcare services, and utilizing effective personal reported outcomes and experiences of consumers with SMI.
Clinical efficacy of metformin in familial adenomatous polyposis and the effect of intestinal flora
Authors: Zhou linxin , Zheng linfu , Xu binbin , Ye zhou , Li dazhou , Wang wen 
Published: November 2023

Abstract
Background and aims
:Metformin has been reported to inhibit the occurrence and development of colorectal cancer (CRC) by mediating changes in intestinal flora.Studies have also indicated that the occurance of familial adenomatous polyposis (FAP) may also be associated with changes in the intestinal flora.Therefore, we investigated the efficacy and safety of metformin in treating FAP and the association with intestinal flora.
Results
Compared with the baseline, the mean number and load of polyps in the areas of nanocarbon labeling and postoperative residuals in the test group were lower than those in the placebo group, while the diversity of intestinal flora species was increased. At the genus level, the relative abundance of g_Ruminococcus in the test group was lower than that at baseline, whereas the relative abundance of g_Lactobacillus was higher. All these changes were statistically significant (p < 0.05).
Conclusion
One-year metformin therapy for FAP is safe and effective, and maybe mediated by modulating the intestinal flora. This study provides new ideas and strategies for the prevention of adenomatous polyp carcinogenesis in FAP and possible mechanisms of preventive action.
Comparative analysis of flood wave modelling methodologies for reservoir failure based on structure from motion
Authors: Lee Jonghyuk , Lee Sang-ik , Jeong Youngjoon , Seo Byung-hun , Kim Dong-su , Seo Ye-jin , Her Younggu , Choi Won 
Published: November 2023

Abstract
Accurate prediction of flood waves from reservoir failures and their propagation is critical to effective flood hazard assessment and risk management. Flood waves are sensitive to floodplain topography, channel geometry, and hydraulic structures located along flow paths in downstream areas, and thus the accuracy of flood wave modelling is dependent on the precision and accuracy of the representation of those features. This study introduces a novel approach to flood wave modelling by accurately representing 3D objects in downstream areas using the Structure-from-Motion (SfM) technique. Through the use of Unmanned Aerial Vehicle (UAV), this method captures topographic complexities, accounting for ground objects like bridges and trees that impact flood propagation. The 3D model offers enhanced representation of turbulent flow dynamics and computational efficiency, especially handling large topography datasets using the volume of fluid (VOF) method. Predictions from this new 3D approach were validated against recent reservoir failure observations and contrasted with traditional 2D models. The results revealed that the 3D model displayed a significant 84.4% reproducibility when juxtaposed with actual inundation traces. It was 35.5%p more accurate than the 2D diffusion wave equation (DWE) and 17.1%p more than the 2D shallow water equation (SWE) methods in predicting flood waves. The DWE was the least accurate among the results, whereas the SWE fared better but still struggled with intricate floodplains. In conclusion, the 3D method, combined with the structure-from-motion technique, emerges as a promising alternative to traditional modelling methods.
Color Fusion Effect on Deep Learning Classification of Uveal Melanoma
Authors: Yao Xincheng , Dadzie Albert , Iddir Sabrina , Abtahi Mansour , Ebrahimi Behrouz , Le David , Ganesh Sanjay , Son Taeyoon , Heiferman Michael 
Published: November 2023

Abstract

Background: Reliable differentiation of uveal melanoma and choroidal nevi is crucial to guide appropriate treatment, preventing unnecessary procedures for benign lesions and ensuring timely treatment for potentially malignant cases. The purpose of this study is to validate deep learning classification of uveal melanoma and choroidal nevi, and to evaluate the effect of color fusion options on the classification performance.
Methods: A total of 798 ultra-widefield retinal images of 438 patients were included in this retrospective study, comprising 157 patients diagnosed with UM and 281 patients diagnosed with choroidal nevus. Color fusion options, including early fusion, intermediate fusion and late fusion, were tested for deep learning image classification with a convolutional neural network (CNN). Specificity, sensitivity, F1-score, accuracy, and the area under the curve (AUC) of a receiver operating characteristic (ROC) were used to evaluate the classification performance. The saliency map visualization technique was used to understand the areas in the image that had the most influence on classification decisions of the CNN.
Results: Color fusion options were observed to affect the deep learning performance significantly. For single-color learning, the red color image was observed to have superior performance compared to green and blue channels. For multi-color learning, the intermediate fusion is better than early and late fusion options.
Conclusion: Deep learning is a promising approach for automated classification of uveal melanoma and choroidal nevi, and color fusion options can significantly affect the classification performance.
A Whole-Food, Plant-Based Randomized Controlled Trial in Metastatic Breast Cancer: Weight, Cardiometabolic, and Hormonal Outcome
Authors: Campbell Thomas M , Campbell Erin K , Culakova Eva , Blanchard Lisa , Wixom Nellie , Guido Joseph , Fetten James , Huston Alissa , Shayne Michelle , Janelsins Michelle C , Mustian Karen M , Moore Richard G , Peppone Luke J 
Published: November 2023

Abstract
Purpose
Breast cancer treatment is associated with weight gain, and obesity and its related cardiometabolic and hormonal risk factors have been associated with poorer outcomes. Dietary intervention may address these risk factors, but limited research has been done in the setting of metastatic breast cancer requiring systemic therapy.
Methods
Women with metastatic breast cancer on stable treatment were randomized 2:1 to an 8-week intervention (n = 21) or control (n = 11). The intervention included weekly assessment visits and an ad libitum whole food, plant-based (WFPB) diet with provided meals. Cardiometabolic, hormonal, and cancer markers were assessed at baseline, 4 weeks, and 8 weeks.
Results
Within the intervention group, mean weight decreased by 6.6% (p < 0.01) after 8 weeks. Fasting insulin decreased from 16.8 uIU/L to 11.2 uIU/L (p < 0.01), concurrent with significantly reduced insulin resistance. Total cholesterol decreased from 193.6 mg/dL to 159 mg/dL (p < 0.01) and low-density lipoprotein (LDL) cholesterol decreased from 104.6 mg/dL to 82.2 mg/dL (p < 0.01). Total testosterone was unchanged, but free testosterone trended lower within the intervention group (p = 0.08) as sex hormone binding globulin increased from 74.3 nmol/L to 98.2 nmol/L (p < 0.01). There were no significant differences in cancer progression markers at week 8, although mean CA 15 − 3, CA 27.29, and CEA were lower in the intervention group (p = 0.53, p = 0.23, and p = 0.54, respectively) compared to control, when adjusted for baseline.
Conclusion
WFPB dietary changes during treatment for metastatic breast cancer are well tolerated and significantly improve weight and cardiometabolic and hormonal parameters. Longer studies are warranted to assess the durability of changes.
Trial registration
First registered at Clinicaltrials.gov (NCT03045289) on February 7, 2017.
“Simple Distant Look Test” wearing Polarized Glasses for Detection of Suppression in Intermittent Exotropia
Authors: Kim Seung-Hyun , Kim Soohyun , Baik Daniel 
Published: November 2023

Abstract
Purpose To evaluate the effectiveness of “Simple distant look test” with Polarized glasses in detecting suppression in patients with intermittent exotropiaMethods This prospective study was performed in patients with basic-type intermittent exotropia greater than 10 prism diopters (PD) at distance (6m) and near (33cm). Vectographic projector test (L29; Luneau Technology, Luneau, France) was used for distant suppression measurement. Positive “Simple distant look test” was defined as constant exodeviation of one eye at distance (6m). Sensitivity, specificity, positive predictive value, and negative predictive value were analyzed (GraphPad Prism® software, Inc., La Jolla, CA, USA).Results 60 patients were included, 40 patients with suppression and 20 patients without suppression. Mean angle of deviation was 20.2 ± 6.0 PD at distance and 20.3 ± 6.0 PD at near. The sensitivity of the test was 100%, the specificity was 95%, positive predictive value was 97.56% and negative predictive value was 100%.Conclusion Due to its simplicity and accuracy, the "Simple distance loot test” could be an alternative to other suppression tests and can be applied to a wide range of age groups.