bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network meta-analysis of comparative efficacy and safety of intubation devices in children
Authors: Ming Yu , Chu Shujuan , Yang Kai , Zhang Zhao , Wu Zhouyang 
Published: October 2023

AbstractTo evaluate the comparative efficacy and safety of different intubation devices on intubation outcomes in pediatric intubation. We identified relevant studies from previous meta-analyses and literature retrieval in PubMed, EMBASE, and Cochrane Library. The primary outcome was the first-pass success (FPS), and the secondary outcome included the time to intubation (TTI) and the risk of local complications (LC). Network meta-analysis was performed using STATA 14.0. Twenty-three randomized comparative trials (RCTs) including 12 devices were included. Compared with Macintosh, Airtraq (odds ratio [OR] = 13.05, 95% confidence interval [CI] = 4.68 to 36.38), Miller (OR = 4.77, 95%CI = 1.32 to 17.22), Glidescope (OR = 2.76, 95%CrI = 1.60 to 4.75) and McGrath (OR = 4.61, 95%CI = 1.18 to 17.99) obtained higher PFS. Meanwhile, Airtraq was superior to Glidescope (OR = 0.21, 95%CI = 0.07 to 0.65) for PFS. For TTI, Canada was superior to other intubation devices, as well as CMAC was superior to TruViewEVO2, Glidescope, and StorzDCI. Airtraq lowered the risk of LC compared with Macintosh and Pentax but there was no statistical difference between Airtraq and KingVision. Airtraq may be the optimal option for FPS, Canada for TTI, and KingVision for LC in pediatric intubation.
Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization
Authors: Yu Feiyan , Yang Yang , Wu Dongchao , Chang Minjing , Han Chong , Wang Qianqian , Li Yi , He Dongning 
Published: October 2023

AbstractInflammatory bowel disease (IBD) and periodontitis are reported to be closely associated; however, whether there is a causal association between them remains unclear. To explore the existence of this causality, this study applied a bidirectional two-sample Mendelian randomization (MR). The genetic variants were obtained from the summary statistics of genome-wide association studies of IBD, including its subtypes CD and UC, and periodontitis. 175, 148, 113, and six single-nucleotide polymorphisms were selected as instrumental variables for IBD, CD, UC, and periodontitis, respectively. In MR analysis, random-effects inverse-variance weighted was used as the primary method, and weighted median and MR Egger regression were applied as the complementary method. A series of sensitivity analyses were also conducted to ensure the reliability of the results. None of these analyses found a significant effect of genetically proxied IBD and its subtypes on periodontitis, and vice versa. Subsequent sensitivity analyses did not detect any horizontal pleiotropy and heterogeneity. Caution should be exerted when it comes to clinical relevance and further studies are needed to clarify the relationship between IBD and periodontitis.
Combining ultrasonic guided wave and low-frequency electromagnetic technology for defect detection in high-temperature Cr–Ni alloy furnace tubes
Authors: Du Chenyang , Li Xiaowei , Liu Chang , Song Ce , Yuan Jun , Xin Yanchao 
Published: October 2023

AbstractCracking furnaces, operating under high temperatures and in a hydrocarbon medium, subject their tubes to complex stresses such as internal pressure, self-weight, fatigue, and thermal shock during start-up and shutdown. As a result, these furnace tubes frequently experience failures characterized by cracks and corrosion perforation. The high-temperature environment, constantly evolving structure of the tubes, and the close arrangement of the cracks within the tube box hinder detecting the cracks using conventional single-detection methods is challenging. This paper breaks through the limitations of the traditional single detection method and studies the effectiveness of the combination of ultrasonic-guided wave and low-frequency electromagnetic detection methods. The experiment was carried out by deliberately making cracks and thinning defects caused by corrosion on the cracking furnace tube of Cr35Ni45Nb after two years of service. The experimental results show that the ultrasonic guided wave detection technology can quickly detect the defects running through the whole furnace tube and effectively identify the manufacturing defects. On the other hand, low-frequency electromagnetic detection makes it possible to scan suspicious local defects and make qualitative and quantitative analyses of defect signals. The combination of ultrasonic guided wave and low-frequency electromagnetic detection can realize the rapid location and comprehensive qualitative and quantitative analysis of furnace tube defects, thus making up for the defects missed detection caused by the lack of effectiveness of single detection and the resulting safety problems. The research results have great popularization value in practical engineering applications.
Role of sex in lung cancer risk prediction based on single low-dose chest computed tomography
Authors: Simon Judit , Mikhael Peter , Tahir Ismail , Graur Alexander , Ringer Stefan , Fata Amanda , Jeffrey Yang Chi-Fu , Shepard Jo-Anne , Jacobson Francine , Barzilay Regina , Sequist Lecia V. , Pace Lydia E. , Fintelmann Florian J. 
Published: October 2023

AbstractA validated open-source deep-learning algorithm called Sybil can accurately predict long-term lung cancer risk from a single low-dose chest computed tomography (LDCT). However, Sybil was trained on a majority-male cohort. Use of artificial intelligence algorithms trained on imbalanced cohorts may lead to inequitable outcomes in real-world settings. We aimed to study whether Sybil predicts lung cancer risk equally regardless of sex. We analyzed 10,573 LDCTs from 6127 consecutive lung cancer screening participants across a health system between 2015 and 2021. Sybil achieved AUCs of 0.89 (95% CI: 0.85–0.93) for females and 0.89 (95% CI: 0.85–0.94) for males at 1 year, p = 0.92. At 6 years, the AUC was 0.87 (95% CI: 0.83–0.93) for females and 0.79 (95% CI: 0.72–0.86) for males, p = 0.01. In conclusion, Sybil can accurately predict future lung cancer risk in females and males in a real-world setting and performs better in females than in males for predicting 6-year lung cancer risk.
Copper and chromium removal from industrial sludge by a biosurfactant-based washing agent and subsequent recovery by iron oxide nanoparticles
Authors: Subsanguan Tipsuda , Jungcharoen Phoomipat , Khondee Nichakorn , Buachan Pantita , Abeyrathne Buddhika Prabath , Nuengchamnong Nitra , Pranudta Antika , Wannapaiboon Suttipong , Luepromchai Ekawan 
Published: October 2023

AbstractIndustrial wastewater treatment generates sludge with high concentrations of metals and coagulants, which can cause environmental problems. This study developed a sequential sludge washing and metal recovery process for industrial sludge containing > 4500 mg/kg Cu and > 5000 mg/kg Cr. The washing agent was formulated by mixing glycolipid, lipopeptide, and phospholipid biosurfactants from Weissella cibaria PN3 and Brevibacterium casei NK8 with a chelating agent, ethylenediaminetetraacetic acid (EDTA). These biosurfactants contained various functional groups for capturing metals. The optimized formulation by the central composite design had low surface tension and contained relatively small micelles. Comparable Cu and Cr removal efficiencies of 37.8% and 38.4%, respectively, were obtained after washing the sludge by shaking with a sonication process at a 1:4 solid-to-liquid ratio. The zeta potential analysis indicated the bonding of metal ions on the surface of biosurfactant micelles. When 100 g/L iron oxide nanoparticles were applied to the washing agent without pH adjustment, 83% Cu and 100% Cr were recovered. In addition, X-ray diffraction and X-ray absorption spectroscopy of the nanoparticles showed the oxidation of nanoparticles, the reduction of Cr(V) to the less toxic Cr(III), and the absorption of Cu. The recovered metals could be further recycled, which will be beneficial for the circular economy.
Feedback between megathrust earthquake cycle and plate convergence
Authors: Martin de Blas Juan , Iaffaldano Giampiero , Tassara Andrés , Melnick Daniel 
Published: October 2023

AbstractOver million years, convergence between the Nazca and South America tectonic plates results in Andean orogeny. Over decades/centuries, it fuels the earthquake cycle of the Andean megathrust. It is well recognised that, over the geologically-long term of million years, Andean orogeny feeds back onto plate convergence rates, generating temporal changes documented throughout the Neogene. In contrast, no feedback mechanism operated over the geologically-short term by the earthquake cycle is currently contemplated. In fact, it is commonly assumed that the rates of contemporary convergence, which are accurately measured via geodesy, remain steady during the megathrust earthquake cycle. Here we investigate whether the contemporary Nazca/South America plate motion varies over year-/decade-long periods in response to megathrust stress variations associated with the earthquake cycle. We focus on the decade preceding the three largest and most recent $${\varvec{M_w > 8}}$$

M
w

>
8

earthquakes (2010 $${\varvec{M_w = 8.8}}$$

M
w

=
8.8

Maule, 2014 $${\varvec{M_w = 8.1}}$$

M
w

=
8.1

Iquique, 2015 $${\varvec{M_w = 8.3}}$$

M
w

=
8.3

Illapel), and find slowdowns of both Nazca and South America whole-plate motions that exceed the impact of data uncertainty or noise. We show that the torque variations required upon Nazca and South America to generate the slowdowns are consistent with that arising from the buildup of interseismic stress preceding the earthquakes.
Proteomic profile of naturally released extracellular vesicles secreted from Leptospira interrogans serovar Pomona in response to temperature and osmotic stresses
Authors: Techawiwattanaboon Teerasit , Phanchamnan Eakalak , Iadsee Nutta , Makjaroen Jiradej , Pisitkun Trairak , Patarakul Kanitha 
Published: October 2023

AbstractBacterial extracellular vesicles (EVs) are generally formed by pinching off outer membrane leaflets while simultaneously releasing multiple active molecules into the external environment. In this study, we aimed to identify the protein cargo of leptospiral EVs released from intact leptospires grown under three different conditions: EMJH medium at 30 °C, temperature shifted to 37 °C, and physiologic osmolarity (EMJH medium with 120 mM NaCl). The naturally released EVs observed under transmission electron microscopy were spherical in shape with an approximate diameter of 80–100 nm. Quantitative proteomics and bioinformatic analysis indicated that the EVs were formed primarily from the outer membrane and the cytoplasm. The main functional COG categories of proteins carried in leptospiral EVs might be involved in cell growth, survival and adaptation, and pathogenicity. Relative to their abundance in EVs grown in EMJH medium at 30 °C, 39 and 69 proteins exhibited significant changes in response to the temperature shift and the osmotic change, respectively. During exposure to both stresses, Leptospira secreted several multifunctional proteins via EVs, while preserving certain virulence proteins within whole cells. Therefore, leptospiral EVs may serve as a decoy structure for host responses, whereas some virulence factors necessary for direct interaction with the host environment are reserved in leptospiral cells. This knowledge will be useful for understanding the pathogenesis of leptospirosis and developing as one of vaccine platforms against leptospirosis in the future.
The use of a Mamdani-type fuzzy model for assessing the performance of a boom stabilization systems in a field sprayer
Authors: Kaliniewicz Zdzisław , Szczyglak Piotr , Lipiński Adam , Markowski Piotr , Lipiński Seweryn 
Published: October 2023

AbstractFuzzy logic models are increasingly used to control simple and complex devices, as well as entire operating systems. In this study, a fuzzy logic model was applied to assess the performance a boom stabilization system in a field sprayer. The model was tested on a field sprayer with a trapezoid system for stabilizing the sprayer boom with a length of 21 m. Measuring cables for registering the displacement of the boom's terminal segments (right and left) in the vertical and horizontal plane were installed on the sprayer. The field sprayer was connected to a tractor. The model was based on two linguistic variables: "absolute displacement of the boom's terminal segments" and "boom stability index". It was assumed that the sprayer boom was stable when the displacement of the boom's terminal segments did not exceed 0.25% of boom length. The study demonstrated that the proposed model can be reliably used to assess boom stability in real time (during field operations). The time required to achieve boom stability was more than 2.5 times shorter in the vertical than in the horizontal plane, which can be attributed mainly to the structure of the stabilization system. The proposed model is universal, and it can be applied to evaluate other boom stabilization systems in field sprayers.
Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target
Authors: Mandal Kamal , Wicaksono Gianina , Yu Clinton , Adams Jarrett J. , Hoopmann Michael R. , Temple William C. , Izgutdina Adila , Escobar Bonell Patiño , Gorelik Maryna , Ihling Christian H. , Nix Matthew A. , Naik Akul , Xie William H. , Hübner Juwita , Rollins Lisa A. , Reid Sandy M. , Ramos Emilio , Kasap Corynn , Steri Veronica , Serrano Juan Antonio Camara , Salangsang Fernando , Phojanakong Paul , McMillan Melanie , Gavallos Victor , Leavitt Andrew D. , Logan Aaron C. , Rooney Cliona M. , Eyquem Justin , Sinz Andrea , Huang Benjamin J. , Stieglitz Elliot , Smith Catherine C. , Moritz Robert L. , Sidhu Sachdev S. , Huang Lan , Wiita Arun P. 
Published: October 2023

AbstractSafely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here we explore the hypothesis that tumor cells express cancer-specific surface protein conformations that are invisible to standard target discovery pipelines evaluating gene or protein expression, and these conformations can be identified and immunotherapeutically targeted. We term this strategy integrating cross-linking mass spectrometry with glycoprotein surface capture ‘structural surfaceomics’. As a proof of principle, we apply this technology to acute myeloid leukemia (AML), a hematologic malignancy with dismal outcomes and no known optimal immunotherapy target. We identify the activated conformation of integrin β2 as a structurally defined, widely expressed AML-specific target. We develop and characterize recombinant antibodies to this protein conformation and show that chimeric antigen receptor T cells eliminate AML cells and patient-derived xenografts without notable toxicity toward normal hematopoietic cells. Our findings validate an AML conformation-specific target antigen and demonstrate a tool kit for applying these strategies more broadly.
Global shortfalls of knowledge on anuran tadpoles
Authors: Vera Candioti Florencia , Baldo Diego , Grosjean Stéphane , Pereyra Martín O. , Nori Javier 
Published: October 2023

AbstractDespite the amount of data on different aspects of biodiversity, such as species distributions, taxonomy, or phylogenetics, there are still significant gaps and biases in the available information. This is particularly true for life history traits, with fragmentary data for most taxa, especially those with complex life cycles. Anurans (frogs and toads) show larval (premetamorphic) stages that are in general radically decoupled from adult forms in most biological aspects. Our understanding of this group is highly uneven, as the main wide-scope investigations focus on adult specimens and larval stages remain unknown for a significant part of the anuran tree. The main purpose of this work was to estimate the extent of knowledge gaps regarding the diversity of tadpoles, interpret their biological and geographical patterns, and discuss possible explanations and implications for other large-scale analyses. Our findings show that more than half of the anuran species described to date still lack information on their embryonic/larval stages. Furthermore, knowledge varies among taxonomic groups, larval ecomorphological guilds, and world ecoregions. Description percentages generally decrease in lineages with a higher proportion of species known or suspected to have endotrophic development. Also, geographic areas with the highest levels of ignorance in larval biology (Tropical Andes and New Guinea) coincide with the highest diversity of endotrophic guilds. Among exotrophic larvae, generalized lentic-lotic tadpoles have the widest distribution and levels of knowledge, whereas specialized lotic, fossorial, and terrestrial forms are more taxonomically and geographically restricted. Further large-scale analyses on tadpole biology are crucial for their impact in varied scientific disciplines including anuran conservation. At a conceptual level, the discussion of the anuran biphasic life cycle is pertinent in the context of shortfalls of biodiversity knowledge and their interrelationships.
Determining an Effective Language Sample Elicitation Strategy for Early Language Learners Who Speak Using Augmentative and Alternative Communication
Authors: Trevino Courtney T. , Lund Emily A. 
Published: October 2023

Purpose:
This study evaluates three different language sample elicitation strategies to determine a valid elicitation strategy for early language learners who speak using augmentative and alternative communication (AAC).

Method:
Ten children who speak using AAC participated in this study. Language samples were elicited from each participant using three strategies: the Communication and Symbolic Behavior Scales (CSBS), a generic play-based elicitation strategy, and automatic data logging. Samples were transcribed and coded. Additionally, each participant's school speech-language pathologist completed a Communication Matrix. Data from coded language samples were correlated with Communication Matrix results to determine the elicitation strategy that yielded the most valid language sample in comparison to Communication Matrix results.

Results:
Both the CSBS and the play-based strategy yielded clinically relevant information. Because the log lacked communicative context, resulting data from the log was limited. An analysis of variance revealed significant differences in the amount of information elicited from each elicitation strategy. The CSBS repeatedly elicited the most data, followed by the play-based strategy and then the log. Generic play-based strategy results yielded the most correlations with Communication Matrix data.

Conclusions:
This preliminary data suggest that the play-based elicitation strategy elicited the most valid language sample when compared to the Communication Matrix from early language learners who speak using AAC. Additionally, results suggest that the CSBS may be an effective tool to measure the limits of this population's expressive language abilities.
The CMB Cold Spot as predicted by foregrounds around nearby galaxies
Authors: Lambas Diego Garcia , Hansen Frode K. , Toscano Facundo , Luparello Heliana E. , Boero Ezequiel F. 
Published: October 2023

Context. The non-Gaussian Cold Spot surrounded by its hot ring is one of the most striking features of the cosmic microwave background (CMB) and has generated significant attention in the literature. It has been speculated that either new physics or the Integrated Sachs-Wolfe effect induced by the presence of a cosmic void at relatively high redshift could account for the observations.
Aims. Here, we investigate if the newly discovered systematic decrease in the CMB temperature in the neighbourhood of nearby galaxies may create such a strong temperature depression. In particular, we note that the largest galaxy group complex in the local Universe, the Eridanus super-group with its neighbouring groups, is in the Cold Spot area. Our goal is to analyse observational galaxy data to characterise the neighbourhood of the Cold Spot, explore the properties of these galaxies, and thereby make a prediction of the galaxy induced CMB temperature decrement in this region.
Methods. We used the Planck SMICA maps, and as foreground tracers, galaxies from the publicly available observational catalogues: 2MRS, 6dF, and HIPASS, which include information on redshifts, positions, magnitudes, and other astrophysical characteristics. We applied previously explored mean temperature profile shapes to model the expected temperature decrement from the galaxies in the Cold Spot area.
Results. Even after correcting for the mean low temperature of the Cold Spot region, we find that the temperature decrement around galaxies is significantly stronger than the mean decrement in other parts of the sky. We discuss whether this could be attributed to the fact that the Cold Spot area coincides with one of the regions populated by the most HI deficient galaxies. Modeling the foreground temperature profile that is mainly associated with spiral galaxies in this location, we find a particularly strong temperature decrement due to the presence of the late-type overabundant largest group complex in the nearby universe. A Cold Spot shape that largely overlaps with the CMB Cold Spot is observed.
Conclusions. We conclude that the coincidence of the only nearby spiral-rich group complex located in the Cold Spot region, and the success of the modelling performed, adds strong evidence to the existence of a local extragalactic foreground that may account for the observed temperature depression, alleviating the tension with the Gaussian field that is otherwise expected in the CMB.
Analyzing the influence of lifter design and ball mill speed on grinding performance, particle behavior and contact forces
Authors: Safa Ali , Aissat Sahraoui 
Published: October 2023

Ball mills are the foremost equipment used for grinding in the mineral processing sector. Lifters are placed on the internal walls of the mill and are designed to lift the grinding media (balls) to a higher position.
In the calculation of energy consumption in ball mills, classical theories mainly consider factors like the charge fill level, lifter dimensions, the number of lifters, and the rotational speed of the mill. This research recognizes the significance of lifter geometry and proposes a new lifter design aimed at optimizing the energy consumption and efficiency of ball mills. Simulation results by discrete elements obtained in this study were validated using experimental results. By conducting this comparative analysis, the aims of the study was to examine the impact of the new lifter's geometry and rotational speed of the mill on torque, power draw, particles behavior, and contact forces. The findings indicate that when the pitch of the lifters is increased, there is a reduction of 3.30% in torque and power consumption. Additionally, this change leads to an increase in the number of cataracting particles and a 6 to 7% increase in contact forces compared to lifters with a straight shape.