bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of 3-year follow up with induction vs first line chemotherapy in oral cancer patients: An observational hospital-based study
Authors: Sahoo Pranab Kumar , Bhowmick Anup Kumar , Sarkar Sinjini , Mahata Sutapa , Pal Ranita , Mistry Tanuma , Ghosh Sushmita , Choudhury Trisha , Kumar R. Suresh , Mondal Syamsundar , Datta Sriparna , Nath Partha , Mukherjee Kalyan Kusum , Nasare Vilas D. 
Published: January 2024

ABSTRACT

Objective:
Our study aims to analyse and compare the efficacy, adverse effect profile and survival among the Paclitaxel/Cisplatin/5-Flurouracil (TPF) induction chemotherapy and Paclitaxel/carboplatin (PC) first line or cisplatin chemotherapy in a high-volume tertiary care cancer centre.

Materials and Methods:
215 patients with oral cavity cancer were recruited in this study. Patients with stages I-IIc underwent surgical resection or radiation therapy 66-74 GY/fraction. Patients of Stages III-IV were administered with either induction chemotherapy TPF or PC or cisplatin regimen. Treatment responses were assessed by CT and MRI. Response rates, survival and adverse effects data were tabulated and analysed.

Results:
The mean age was 49.2 ± 11.68 years. Symptoms were ulceration (33.5%), growth (20.5%), pain (13%), ulcer-proliferative growth (8.4%) and swelling (13, 6%). The tumour site was found at the base of the tongue, C01 (42.2%) followed by C06 (35.8%), C08 (6.5%), C07 (5.2%) and C05 (4.6%). There were no significant differences (P > 0.05) in efficacy and survival outcomes between the different groups of treatment. Median survival was achieved within 36 months. The major side effect observed were anaemia (15.81%), diarrhoea (36.2%), dyspepsia (28.8%), fever (33.95%), mucositis (28.85%), myalgia (33.95%) and nausea (7.9%). Survival among the responder categories (CR, PR and NR) was significantly different as per Log-rank analysis (P = 0.015).

Conclusions:
TPF induction therapy and PC first line chemotherapy showed similar efficacy, safety profile and survival whereas cisplatin shows poor efficacy and safety and survival in Indian oral cancer patients.
Pancreatic heterotropia in gallbladder with adenocarcinoma: A rare incidental finding
Authors: Rana Deepika , Paul Sreoshi , Mallya Varuna , Mandal Shramana , Vindal Anubhav , Singh Kishore 
Published: January 2024

ABSTRACT
Heterotopic pancreas is defined as the presence of aberrant pancreatic tissue present outside the pancreas without connection to its neural, vascular, and anatomic location. The commonly seen locations are stomach, duodenum, jejunum, Meckel commonly seen locatio, and ampulla of Vater. The gallbladder is an extremely rare site for pancreatic heterotropia. Its association with adenocarcinoma has not been described yet. A case of 50-year-old male with pancreatic heterotropia along with carcinoma gallbladder is being presented here.
Oral glutamine: Is there a role in the amelioration of radiation-induced mucositis? A prospective case-control study at a tertiary care centre in North India
Authors: Fatima Kaneez , Andleeb Asifa , Nasreen Shahida , Sofi Mushtaq A. , Najmi Arshad M. , Qadri Sumyra K. , Ryhan Rubyiya , Roohi Shagufta , Afroz Fir , Khan Nazir A. 
Published: January 2024

ABSTRACT

Background:
The most frequently occurring painful and dose-limiting side effect of radiation therapy (RT) to the head and neck region is oral mucositis (OM). Several studies demonstrated that glutamine may reduce the severity and the duration of OM significantly during RT and chemo-radiotherapy in patients with head and neck cancer (HNC).

Materials and Methods:
Between January 2021 and August 2022, a prospective single institutional case-control study compared the efficacy and safety of oral glutamine on radiation-induced mucositis in patients with HNC. Of 60 biopsy-proven patients with HNC, 30 patients in the study arm received oral glutamine suspension (10 g in 500 mL of water) orally once daily, 2 hours before RT, receiving definitive or adjuvant RT and chemo-radiotherapy, while as 30 patients in the control arm received placebo with the same dose and schedule (n = 30 in the study arm and n = 30 in the control arm).

Results and Analysis:
A total of 27 (90%) in the glutamine arm and 28 (93.33%) patients in the control arm developed mucositis. Grade 3 mucositis (13.33%) and Grade 4 mucositis (6.66%), respectively, were significantly less (P = .040 and P = .004) in the glutamine arm. The mean duration of grade 3 and grade 4 mucositis was significantly less in the glutamine arm (8.94 days in the study arm vs. 14.54 in the control arm; P = .0001). The mean time of onset of OM was significantly delayed in the glutamine arm in comparison to the control arm with P < .001.

Conclusion:
Glutamine delays the onset of OM and decreases the severity of OM in patients of HNC receiving RT with or without chemotherapy.
Periprosthetic metastases in carcinoma of unknown primary: A rare association
Authors: Singla Aditya , Goyal Shikha , Mitra Saikat , Kumar Rajender , Periasamy Kannan , Bal Amanjit , Madan Renu , Khosla Divya 
Published: January 2024

ABSTRACT
Septic or aseptic loosening may cause bone loss around artificial prosthesis leading to prosthesis failure. This occurrence due to metastatic infiltration of bone or surrounding soft tissues is rare but has been occasionally reported. We report a case of an elderly lady presenting with swelling and pain at the site of previous hemiarthroplasty performed for traumatic injury. On evaluation, she was found to have a lytic femur lesion with a large soft-tissue component around the prosthetic joint. Biopsy suggested a metastatic carcinoma of renal origin, but screening of kidneys did not reveal any primary lesion. She had additional skeletal metastatic lesions but no other primary site was detected either. She was given palliative radiotherapy and systemic therapy (sunitinib) based on the histologic diagnosis of renal cell origin but did not tolerate it. Thereafter, she is continuing on zoledronate every 4 weeks and best supportive management since 4 months from diagnosis.
Metastatic papillary thyroid carcinoma masquerading as lymphangioma: A rare case report and review of literature
Authors: Goswami Rashmi R. , Daimary Michimi , Datta Balmiki , Bordoloi Krishangee , Anam Piyar 
Published: January 2024

ABSTRACT
Papillary thyroid carcinoma coexisting with lymphangioma is a rare presentation of a cystic neck mass. Here, we report a case of papillary thyroid carcinoma masquerading as lymphangioma in the neck clinically and radiologically. Our patient was a 31-year-old man who presented with swelling on the left side of the neck for four months. A detailed history and investigation are summarized, and a review of published literature on similar cases is obtained. The initial computed tomography (CT) scan reported it as lymphangioma, and the fine-needle aspiration cytology (FNAC) reported it as a cystic lesion. However, the excision biopsy showed a picture of metastatic papillary carcinoma of the thyroid with cystic changes and associated lymphangioma. The patient finally underwent total thyroidectomy, which again revealed multifocal papillary thyroid carcinoma with capsular invasion and lymph node metastasis on histopathological examination (HPE). Primary occult carcinoma of the thyroid with metastatic deposits presenting as lymphangioma is a very rare presentation of a cystic neck mass, and very few cases have been reported in the English language literature.
Pylephlebitis-induced acute liver failure: A case report and review of literature
Authors: Hapshy Vera , Imburgio Steven , Sanekommu Harshavardhan , Nightingale Brandon , Taj Sobaan , Hossain Mohammad A , Patel Swapnil 
Published: January 2024

BACKGROUND
Pylephlebitis is an extremely rare form of septic thrombophlebitis involving the portal vein, carrying high rates of morbidity and mortality.
CASE SUMMARY
We present a case of a 42-year-old male with no past medical history who presented with acute onset of abdominal pain and altered mental status with laboratory tests demonstrating new-onset acute liver failure. Pylephlebitis was determined to be the underlying etiology due to subsequent workup revealing polymicrobial gram-negative anaerobic bacteremia and complete thrombosis of the main and left portal veins. To our knowledge, this is the first documented case of acute liver failure as a potential life-threatening complication of pylephlebitis.
CONCLUSION
Our case highlights the importance of considering pylephlebitis in the broad differential for abdominal pain, especially if there are co-existing risk factors for hypercoagulability. We also demonstrate that fulminant hepatic failure in these patients can potentially be reversible with the immediate initiation of antibiotics and anticoagulation.
Direct-acting antivirals failed to reduce the incidence of hepatocellular carcinoma occurrence in hepatitis C virus associated cirrhosis: A real-world study
Authors: Tao Xue-Mei , Zeng Ming-Hui , Zhao You-Fei , Han Jia-Xin , Mi Yu-Qiang , Xu Liang 
Published: January 2024

BACKGROUND
Direct-acting antivirals (DAAs) revolutionized the treatment of chronic hepatitis C virus (HCV)-associated disease achieving high rates of sustained virological response (SVR). However, whether DAAs can reduce the occurrence of hepatocellular carcinoma (HCC) in patients with HCV-associated cirrhosis who are at high risk have not been concluded.
AIM
To investigate the effect of DAAs on the occurrence of HCC in patients with HCV-associated cirrhosis after achieving SVR.
METHODS
Of 427 inpatients with HCV-associated cirrhosis were enrolled in Tianjin Second People's Hospital from January 2014 to April 2020. 118 patients weren’t received antiviral treatment with any reasons named non-antiviral treatment group, and 236 patients obtained from the 309 DAAs treatment patients according to the propensity score matching named DAAs treatment group. Demographic information and laboratory data were collected from baseline and the following up. Kaplan-Meier curve and Log-Rank test were used to compare the incidence and cumulative incidence of HCC between the two groups. Cox proportional risk regression was used to re-evaluate the risk factors for HCC.
RESULTS
HCC incidence was 4.68/100PY (95%CI, 3.09-6.81) in the DAAs treatment group, while it was 3.00/100PY (95%CI, 1.50-5.37) in the non-antiviral treatment group, and the relative risk was 1.82 (95%CI, 0.93-3.53, P > 0.05). The incidence of HCC at 12, 24, 36 and 48 months was 3.39%, 6.36%, 8.47% and 10.17% in the DAAs treatment group, and it was 0%, 0%, 3.39% and 9.32% in the non-antiviral treatment group, respectively. Age > 58 [hazard ratio (HR) = 1.089; 95%CI, 1.033-1.147; P = 0.002] and liver stiffness measurement > 27.85 kPa (HR = 1.043; 95%CI, 1.022-1.065; P = 0.000) were risk factors for HCC in all patients (n = 427), and DAAs treatment didn’t show protective efficacy.
CONCLUSION
DAAs treatment seems failed to reduce the incidence of HCC occurrence in HCV-associated cirrhosis in 48 months, and even increased the incidence of HCC in 36 months.
Subcellular distribution of prohibitin 1 in rat liver during liver regeneration and its cellular implication
Authors: Sun Qing-Ju , Liu Tao 
Published: January 2024

BACKGROUND
The function of prohibitin 1 (Phb1) during liver regeneration (LR) remains relatively unexplored. Our previous research identified downregulation of Phb1 in rat liver mitochondria 24 h after 70% partial hepatectomy (PHx), as determined by subcellular proteomic analysis.
AIM
To investigate the potential role of Phb1 during LR.
METHODS
We examined changes in Phb1 mRNA and protein levels, subcellular distribution, and abundance in rat liver during LR following 70% PHx. We also evaluated mitochondrial changes and apoptosis using electron microscopy and flow cytometry. RNA-interference-mediated knockdown of Phb1 (PHBi) was performed in BRL-3A cells.
RESULTS
Compared with sham-operation control groups, Phb1 mRNA and protein levels in 70% PHx test groups were downregulated at 24 h, then upregulated at 72 and 168 h. Phb1 was mainly located in mitochondria, showed a reduced abundance at 24 h, significantly increased at 72 h, and almost recovered to normal at 168 h. Phb1 was also present in nuclei, with continuous increase in abundance observed 72 and 168 h after 70% PHx. The altered ultrastructure and reduced mass of mitochondria during LR had almost completely recovered to normal at 168 h. PHBi in BRL-3A cells resulted in increased S-phase entry, a higher number of apoptotic cells, and disruption of mitochondrial membrane potential.
CONCLUSION
Phb1 may contribute to maintaining mitochondrial stability and could play a role in regulating cell proliferation and apoptosis of rat liver cells during LR.
PENGARUH PENDIDIKAN KESEHATAN TENTANG TANDA BAHAYA PADA KEHAMILAN TERHADAP PENGETAHUAN PENCEGAHAN RESIKO KEHAMILAN
Authors: Nirwana Betanuari Sabda , Nikmah Anis Nikmatul , Laili Fauzia , Larasati Nadya Sukma , Nggiri Aprilia S.R. May 
Published: January 2024

Latar belakang: Pelayanan kesehatan ibu hamil memerlukan pengawasan selama kehamilan supaya tidak terjadi kehamilan patologis serta mencegah naiknya Angka Kematian Ibu (AKI) maupun Angka Kematian Bayi (AKB). Indikator kesehatan ibu hamil merupaka cermin kemampuan setiap bangsa dalam memberikan pelayanan medis terhadap masyarakatnya. Pelayanan kesehatan dianjurkan untuk menjamin perlindungan terhadap ibu hamil dan janin berupa deteksi dini faktor risiko, pencegahan, dan penanganan dini komplikasi kehamilan. Tujuan: Penelitian ini untuk mengetahui pengaruh pendidikan kesehatan tentang tanda bahaya pada kehamilan terhadap pengetahuan pencegahan resiko kehamilan. Metode: Penelitian kuantitatif dengan desain pre-eksperimen, teknik sampling yang digunakan Simple Random Sampling dengan jumlah responden 16 ibu hamil. Analisis data yang digunakan yaitu wilcoxon signed – rank test. Hasil penelitian : ini menunjukkan bahwa dari 16 responden ibu hamil dilakukan diperoleh Asymp. Sig (2-tailed) sebesar 0,014 < (α = 0,05), maka Ho ditolak dan H1 diterima artinya ada Pengaruh Penyuluhan terhadap Perilaku pencegahan resiko kehamilan Pada ibu hamil Di Puskesmas Fak Fak Tengah Provinsi Papua Barat Tahun 2022 Tahun 2022. Sedangkan negative rank: 0, Positive rank : 6, Ties: 10. Dengan adanya penelitian ini diharapkan ibu mempunyai pengetahuan yang baik tentang tanda bahaya pada kehamilan agar ibu hamil dapat mencegah resiko kehamilan.
HUBUNGAN PERAWATAN LUKA PERINEUM DENGAN PENYEMBUHAN LUKA PERINEUM IBU POST PARTUM
Authors: Sholikha Siti , Muthoharoh Husnul 
Published: January 2024

Labor often result in the birth canal laceration, laceration occurred in nearly all deliveries the first time and not infrequently in the next birth. Resulting in laceration injuries that lead to treatment and should be done so that the perineal wounds can heal normally. This study aimed to determine whether there is a relationship between the perineal wound care with perineal wound healing in post partum. The research design used in this research using correlational analytic methods to the type design Cohort. The population in this study were 27 post partum at BPS Mrs. Aida W., Amd.Keb Dlanggu Village near Lamongan District. Sample was used as many as 26 respondents in accordance with inclusion criteria, and were taken by Simple Random Sampling is, taking samples from members of the population conducted randomly without regard to strata that exist in this population, with a variable is a treatment depedennya perineal wound healing was the independent variable is perineal wound. Data obtained and processed using the Chi square test with α = 0.05. Results showed that respondents who do care very well and recovered to normal as much as nine respondents (90%), while the treatment is not good and slow recovery is nine respondents (56.2%). From the results of the chi-square test p value = 0.018 where p <0.05. This shows that H0 is rejected. It can be concluded from this study that there is relationship between the perineal wound care perineumnya with healing wounds, so in this case is expected for post partum mothers to be more better in the treatment of wounds can be healed wounds perineumnya supaya to normal.
HUBUNGAN PENGGUNAAN KONTRASEPSI SUNTIK DMPA DENGAN KENAIKAN BB DI PMB ENDANG SUPRIYATI
Authors: Faiqoh Intan Elok , Mahmudah Nurul 
Published: January 2024

Latar Belakang : Salah satu metode dan alat kontrasepsi di Indonesia adalah metode kontrasepsi suntik. Tingginya minat pemakai kontrasepsi suntik ini karena kepraktisan dan kepercayaan tentang ampuhnya suntikan. Cara ini diakui sebagai cara aman dan sederhana. Metode : penelitian ini mengguanakan metode observasi analitik untuk mengetahui hubungan penggunaan kontrasepsi suntik DMPA dengan kenaikan berat badan akseptor di PMB Endang Supriyati Penelitian ini menggunakan pendekatan Cross sectional. Hasil : Penggunaan kontrasepsi suntik DMPA di PMB Endang Supriyati dengan penggunaan 1-3 tahun sebanyak sebanyak 53 responden atau (75,7 %) dan pengguna lebih dari 3 tahun sebanyak 18 responden atau (24,3%).Kenaikan berat badan badan normal terdapat 4 responden atau (5,7%) dan berat badan naik terdapat 66 responden atau (94,3%). Kesimpulan : Hubungan penggunaan kontrasepsi suntik DMPA Dengan kenaikan berat badan di PMB Endang Supriyati mendapatkan nilai p 0,003 (<0,05). Hal ini menunjukkan adanya hubungan yang signifikan antara penggunaan kontrasepsi suntik DMPA dengan kenaikan berat badan. Semakin tinggi penggunaan kontrasepsi suntik DMPA, semakin rendah kenaikan berat badan terjadi atau semakin rendah penggunaan kontrasepsi suntik DMPA, semakin tinggi kenaikan berat badan terjadi
PERBEDAAN EFEKTIFITAS JUS MENTIMUN DAN AIR REBUSAN SELEDRI TERHADAP PENURUNAN TEKANAN DARAH PADA MENOPAUSE
Authors: Dewi Rahma Kusuma , Kusumawati Lindha Sri , Fitriasnani Meirna Eka , Himmah Fithri Rif’atul 
Published: January 2024

Pendahuluan : Hipertensi atau tekanan darah tinggi adalah sebuah kondisi medis saat seseorang mengalami peningkatan tekanan darah diatas normal. Lebih dari setengah wanita menopause mengalami hipertensi. Jumlah menopause yang datang ke puskesmas dengan hipertensi adalah 68 (1,73%) orang Penyakit hipertensi jika dibiarkan akan menyebabkan kerja jantung lebih keras dan terjadi kerusakan dinding pembuluh darah lebih cepat sehingga dapat menyebabkan kematian. Tujuan penelitian ini adalah mengetahui efektifitas pemberian jus mentimun dengan air rebusan seledri terhadap penurunan tekanan darah pada menopause. Metode : Penelitian ini menggunakan pendekatan Quasy Eksperiment. Populasi yang digunakan dalam penelitian ini adalah 85 orang Menopause usia 48-65 tahun dengan teknik pengambilan sampel menggunakan purposive sampling. Hasil : Hasil penelitian dari rata-rata tekanan darah responden yang diberi air rebusan seledri memiliki tekanan darah lebih rendah dari pada responden yang diberi air rebusan seledri yaitu sebesar 138,12/94,37 mmhg<145,00/95,00 mmHg. Dilihat dari data menunjukkan p-value pada sistolik sebesar 0,02 atau p < α (0,05), p-value pada diastolik sebesar 0,04 atau p < α (0,05), maka H0 ditolak dan H1 diterima yang berarti ada efektifitas pemberian jus mentimun dengan air rebusan seledri terhadap penurunan tekanan darah pada menopause dan air rebusan seledri lebih efektif terhadap penurunan tekanan darah pada menopausedengan hipertensi. Diskusi : Dapat disimpulkan bahwa ada air rebusan daun seledri lebih efektif daripada jus mentimun di Posyandu Seroja Kabupaten Kediri.Responden disarankan untuk memilih alternative penurunan tekanan darah dengan menggunakan jus daun seledri.
PENGARUH BUAH JERUK MANIS KEPROK (CITRUS RETICULATA) TERHADAP PENINGKATAN KADAR HEMOGLOBIN PADA IBU HAMIL
Authors: Intiyaswati Intiyaswati , Primihastuti Dianita , Tono Sendy Firza Novilia , Aprilia Devi 
Published: January 2024

Salah satu adaptasi fisiologis kehamilan trismester III terjadi peningkatan plasma yang relatif lebih cepat sehingga menyebabkan terjadinya hemodilusi fisiologi yang mengakibatkan perubahan kadar hemoglobin. Studi pendahuluan di TPMB Any Iswahyuni pada 16 ibu hamil trimester III menunjukkkan 2 ibu hamil dengan kadar Hb 8 gr % , 8 ibu hamil dengan kadar Hb 9,9 gr %, dan 6 ibu hamil memiliki 11,5 gr %, yang menandakan bahwa ibu hamil trismester III tersebut mengalami anemia ringan. Salah satu kandungan buah jeruk adalah vitamin C yang berfungsi membantu penyerapan zat besi. Penelitian yang dilakukan bertujuan untuk mengetahui pengaruh pemberian jeruk manis keprok (citrus reticulata) terhadap kadar hemoglobin pada ibu hamil trismester III di TPMB Any Iswahyuni tahun 2023. Penelitian ini merupakan penelitian pre-eksperimen dengan tujuan analitik. Populasi yang diteliti adalah ibu hamil yang berjumlah 18 responden yang diambil dari teknik accidental sampling. Data dianalisis menggunakan uji normalitas shapiro wilk dihasilkan ρ > α (α =0,05 ) yaitu ρ =0,020 dan 0,006 maka distribusi nilainya adalah tidak normal sehingga uji yang digunakan adalah uji statistik wilcoxon di dapatkan hasil ρ =0,027 dengan tingkat kepercayaan 95% (α=0,05) yang artinya ρ value < α yang berarti H0 ditolak dan H1 diterima maka ada pengaruh pemberian Buah Jeruk Manis Keprok (citrus reticulata) terhadap kadar hemoglobin pada ibu hamil trimester III di TPMB Any Iswahyuni Surabaya tahun 2023. Hasil ada pengaruh pemberian Buah Jeruk Manis Keprok (citrus reticulata) terhadap kadar hemoglobin pada ibu hamil trimester III di TPMB Any Iswahyuni Surabaya tahun 2023. Disarankan ibu hamil trismester III mengkonsumsi tablet fe disertai buah jeruk karena terbukti dapat membantu meningkatkan penyerapan zat besi pada tubuh sehingga dapat meningkatkan kadar hemoglobin
PEMANFAATAN BUAH PISANG SEBAGAI TERAPI NON FARMAKOLOGIS DAN KEARIFAN LOKAL DALAM UPAYA PENCEGAHAN PREEKLAMSIA KEHAMILAN
Authors: Tono Sendy Firza Novilia , Aprilia Devi 
Published: January 2024

Kematian ibu di Indonesia masih didominasi oleh tiga penyebab utama yaitu perdarahan, hipertensi dalam kehamilan (HDK), dan infeksi. Preeklampsia dan eklampsia merupakan penyebab utama mortalitas dan morbiditas ibu dan bayi. Insiden preeklampsia adalah 7-10% dari kehamilan dan merupakan penyebab kematian ibu nomor dua di Indonesia. Dalam penatalaksanaan preeklampsia upaya yang dilakukan berupa upaya nonfarmakologis (memodifikasi gaya hidup melalui pendidikan kesehatan) dengan memanfaatkan buah pisang sebagai upaya terapi nonfarmakologis dalam pencegahan preeklamsia. Tujuan kegiatan pengabdian ini adalah untuk meningkatkan pengetahuan kesehatan kepada masyarakat. Pelaksanaan kegiatan ini berupa penyuluhan dan edukasi cara mengonsumsi dan memadukan dengan gaya hidup berolaraga. Penyuluhan dilakukan dengan memberikan materi seputar preeklampsia dan bahayanya dan penatalaksanaannya. Penilaian untuk mengetahui tingkat pengetahuan peserta dilakukan sebanyak 2 kali, yaitu dilakukan pre-test dan post-test. Hasil dari kegiatan pengabdian ini didapatkan bahwa saat pre-test sekitar 75% ibu hamil mengetahui tentang preeklampsia dan bahayanya. Setelah dilakukan penyuluhan kesehatan, terjadi peningkatan secara signifikan tingkat pengetahuan Sebagian besar bidan menjadi 100%.