bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 10-year retrospective study of methicillin-resistant Staphylococcus aureus from burn wound infection in southeast China from 2013 to 2022
Authors: Gu Feifei , He Weiping , Zhu Dedong , Yang Peilang , Sun Jingyong , Han Lizhong 
Published: December 2023

BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) is one of the most commonly encountered pathogens among burn patients incurring substantial morbidity and mortality. To investigate the epidemiology and features of MRSA in burn wound infections, we conducted a 10-year retrospective study on MRSA isolated from burn patients with burn wound infections from southeast China from 2013 to 2022.MethodsOne hundred MRSA isolates (10 isolates each year) from burn wound infection among burn patients from 2013 to 2022 were randomly selected and enrolled. In addition to the clinical data of the 100 burn patients, MRSA isolates were characterized by antimicrobial susceptibility testing, detection of toxin genes, and molecular typing.ResultsThe median time from the onset of burns and admission to MRSA detected was 13 and 5 days, respectively. No MRSA isolate was found resistant to quinupristin/dalfopristin, linezolid, and vancomycin. Toxin gene seg was found most frequently (90%) followed by sea (70%) and eta (64%). CC8 (74%), ST239 (70%), and SCCmec III (72%) were the most common CC, ST, and SCCmec types, respectively.ConclusionST239-III (70%) was the predominant clone found in MRSA from burn wound infection among burn patients in southeast China. ST239-III was less found from 2018 to 2022. A higher diversity of MRSA clones was observed in these recent 5 years than that from 2013 to 2017.
An integrated workflow for 2D and 3D posture analysis during vestibular system testing in mice
Authors: Wan Yong , Edmond Michaela A. , Kitz Colin , Southern Joseph , Holman Holly A. 
Published: December 2023

IntroductionPosture extraction from videos is fundamental to many real-world applications, including health screenings. In this study, we extend the utility and specificity of a well-established protocol, the balance beam, for examining balance and active motor coordination in adult mice of both sexes.ObjectivesThe primary objective of this study is to design a workflow for analyzing the postures of mice walking on a balance beam.MethodsWe developed new tools and scripts based on the FluoRender architecture, which can interact with DeepLabCut (DLC) through Python code. Notably, twenty input videos were divided into four feature point groups (head, body, tail, and feet), based on camera positions relative to the balance beam (left and right), and viewing angles (90° and 45° from the beam). We determined key feature points on the mouse to track posture in a still video frame. We extracted a standard walk cycle (SWC) by focusing on foot movements, which were computed by a weighted average of the extracted walk cycles. The correlation of each walk cycle to the SWC was used as the weight.ResultsWe learned that positions of the camera angles significantly improved the performance of 2D pose estimation (90°) and 3D (45°). Comparing the SWCs from age-matched mice, we found a consistent pattern of supporting feet on the beam. Two feet were consistently on the beam followed by three feet and another three feet in a 2-3-3 pattern. However, this pattern can be mirrored among individual subjects. A subtle phase shift of foot movement was also observed from the SWCs. Furthermore, we compared the SWCs with speed values to reveal anomalies in mouse walk postures. Some anomalies can be explained as the start or finish of the traversal, while others may be correlated to the distractions of the test environment, which will need further investigation.ConclusionOur posture analysis workflow improves the classical behavioral testing and analysis, allowing the detection of subtle, but significant differences in vestibular function and motor coordination.
Inhalation-modulated detection of olfactory BOLD responses in the human brain
Authors: Alahäivälä Aino-Lotta I. , Thaploo Divesh , Wein Simon , Seidel Philipp , Riebel Marco , Hummel Thomas , Schwarzbach Jens Volkmar 
Published: December 2023

IntroductionIn contrast to other sensory domains, detection of primary olfactory processes using functional magnetic resonance imaging has proven to be notably challenging with conventional block designs. This difficulty arises from significant habituation and hemodynamic responses in olfactory areas that do not appear to align with extended boxcar functions convolved with a generic hemodynamic response model. Consequently, some researchers have advocated for a transition to event-related designs, despite their known lower detection power compared to block designs.MethodsHere, we conducted a block design experiment with 16s of continuous odorant stimulation alternating with 16s of continuous odorless air stimulation in 33 healthy participants. We compared four statistical analyses that relied either on standard block designs (SBD1-2) or on block designs that were modulated by the participants' individual breathing patterns (MBD1-2).ResultsWe found that such modulated block designs were comparatively more powerful than standard block designs, despite having a substantially lower design efficiency. Using whole-brain effect size maps, we observed that the right insular and medial aspects of the left piriform cortex exhibited a preference for a breathing-modulated analysis approach.DiscussionResearch in olfaction that necessitates designs with longer-lasting blocks, such as those employed in the investigation of state-dependent processing, will benefit from the breathing-modulated analyses outlined in this study.
Ribociclib-induced liver injury: a case report
Authors: Schaeffer Sofia , Lutz Christian , Dobbie Michael , Terracciano Luigi M. , Matter Matthias , Vosbeck Jürg , Heim Markus H. , Bernsmeier Christine 
Published: December 2023

BackgroundIdiosyncratic drug-induced liver injury (DILI) is a rare, unpredictable hepatic adverse event and the most common cause of acute liver failure in Europe and the US. Ribociclib is a potent Cyclin-dependent kinase 4 and 6 (CDK4/6)-inhibitor administered for advanced hormone-receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Previous reports have shown hepatotoxicity without liver necrosis related to ribociclib.Case presentationA 41-year-old female patient with primary metastatic HR-positive, HER2-negative breast cancer developed liver enzyme elevation under treatment with ribociclib. Ribociclib was withdrawn 8 weeks after initiation due to liver enzyme elevation. A liver biopsy, performed due to further enzyme increase (peak ALT 2836 U/l), onset of jaundice (peak bilirubin 353 µmol/l) and coagulopathy (INR 1.8) two weeks later, revealed acute hepatitis with 30% parenchymal necrosis. Roussel Uclaf Causality Assessment Method (RUCAM) score was 7 points (probable). Under treatment with prednisone (60mg), initiated 2 weeks after drug withdrawal, and subsequently N-acetylcysteine (Prescott regimen) liver enzymes normalized within 8 weeks along with prednisone tapering.ConclusionThis case illustrates the development of a severe idiosyncratic hepatocellular pattern DILI grade 3 (International DILI Expert Working Group) induced by ribociclib. Routine liver enzyme testing during therapy, immediate hepatologic work-up and treatment interruption in case of liver enzyme elevation are highly recommended. Corticosteroid treatment should be considered in cases of severe necroinflammation.
Design, synthesis, and evaluation of 4-(3-(3,5-dimethylisoxazol-4-yl)benzyl)phthalazin-1(2H)-one derivatives: potent BRD4 inhibitors with anti-breast cancer activity
Authors: Li Yingpeng , Chu Xinhong , Yin Yu , Li Hongkun , Fu Hui , Feng Xinchi , Deng Yanru , Ge Jun 
Published: December 2023

BRD4 inhibitors have demonstrated promising potential in cancer therapy. However, their therapeutic efficacy in breast cancer varies depending on the breast cancer subtype, particularly in the treatment of TNBC. In this study, we designed and synthesized 94 derivatives of 4-(3-(3,5-dimethylisoxazol-4-yl)benzyl)phthalazin-1(2H)-one to evaluate their inhibitory activities against BRD4. Notably, compound DDT26 exhibited the most potent inhibitory effect on BRD4, with an IC50 value of 0.237 ± 0.093 μM. DDT26 demonstrated significant anti-proliferative activity against both TNBC cell lines and MCF-7 cells. Intriguingly, the phthalazinone moiety of DDT26 mimicked the PAPR1 substrate, resulting in DDT26 displaying a moderate inhibitory effect on PARP1 with an IC50 value of 4.289 ± 1.807 μM. Further, DDT26 was shown to modulate the expression of c-MYC and γ-H2AX, induce DNA damage, inhibit cell migration and colony formation, and arrest the cell cycle at the G1 phase in MCF-7 cells. Our findings present potential lead compounds for the development of potent anti-breast cancer agents targeting BRD4.
The role of external factors on the reactivation of the heritage language of Turkish-German returnees
Authors: Antonova-Unlu Elena , Bayram Fatih 
Published: December 2023

IntroductionThis study investigates the heritage language performance of Turkish-German returnees upon their reintegration into Turkey and explores the impact of external factors on their proficiency in the (re-)activated heritage language (HL).MethodsData collection involved the participation of 28 Turkish heritage speakers and a control group of 28 monolingual speakers. The language proficiency of both groups was assessed through a cloze test and an error correction task with a focus on converbial constructions, evidentiality and direct object case marking in Turkish. A sociolinguistic background questionnaire was used to obtain information about their language experiences. The study focused on understanding the individual and group differences in returnee’s heritage language performance. Additionally, random forest analysis was employed to investigate the relative influence of external factors on individual variability within the returnee group.Results and DiscussionThe analysis of results revealed notable group differences between the returnees and the control group, emphasizing the unique linguistic challenges faced by those who returned to Turkey. Within the returnee group, there was considerable individual variability in heritage language performance. The subsequent exploration of individual variation highlighted the significant role of external factors. Notably, the length of residence in Germany, the age at which participants returned to Turkey, and the frequency of Turkish language use in their migration context emerged as significant predictors of the returnee participants’ proficiency in their (re-)activated HL. Surprisingly, formal contact with the dominant German language did not exert a substantial impact on the returnees’ language proficiency, suggesting the nuanced influence of various external factors on heritage language development.
Future of nature, our future. A preregistered report on future time perspective, social value orientation, and pro-environmental outcomes based on data from Poland and Sweden
Authors: Nowakowska Iwona , Rönnlund Michael 
Published: December 2023

IntroductionThe objective of the study was to examine the role of social value orientation and future time perspective to account for individual differences in pro-environmental behaviors, intentions, and opinions about the link between pro-environmental action and pandemic threat (three separate models) in Polish and Swedish samples expected to differ in rate of pro-environmental behaviors (higher in Sweden). We hypothesized that for Poland, future time perspective would be linked to pro-environmental outcomes only when social value orientation is average or high. In contrast, for Sweden, we expected a significant link between these variables regardless of social value orientation.MethodsIn total, 301 (150 Polish, 151 Swedish) participants completed online surveys via Prolific.co research panel. We controlled for individualizing/binding moral foundations, present time perspectives, and selected demographic variables in the analyses.ResultsIn line with expectations, the individualizing moral foundations were a significant predictor across all three models. The data did not support our focal hypothesis regarding the interaction between future time perspective and social value orientation. For pro-environmental behaviors in the past 6 months, the future time perspective was a predictor only when social value orientation was low.DiscussionThe results suggest that when encouraging more competitive (compared to altruistic) people to behave in a green way, it might be crucial to underline the future consequences and benefits, consistent with the future time perspective. The pro-environmental campaigns could, therefore, highlight how green behavior may bring personal gains in the future, which are typically valued by individualistic people, such as savings or social status.
Participant experiences of guided self-help Acceptance and Commitment Therapy for improving quality of life in muscle disease: a nested qualitative study within the ACTMus randomized controlled trial
Authors: Edwards Victoria , Vari Chiara , Rose Michael , Graham Christopher D. , O'Connell Nicola , Taylor Emma , McCracken Lance M. , Radunovic Aleksandar , Rakowicz Wojtek , Norton Sam , Chalder Trudie 
Published: December 2023

IntroductionIn adults, muscle disease (MD) is typically a chronic long-term condition that can lead to a reduced quality of life (QoL). Previous research suggests that a psychological intervention, in particular Acceptance and Commitment Therapy (ACT), may help improve QoL for individuals living with chronic conditions such as MD.MethodsThis nested qualitative study was incorporated within a randomized controlled trial which evaluated a guided self-help ACT intervention for people living with MD to explore their experiences of the intervention. Semi-structured interviews (n = 20) were conducted with those who had received ACT. Data were analyzed via thematic analysis.ResultsThere were four overarching themes. (1) Views on whether therapy sessions would help with a medical condition: participants' expectations regarding ACT varied. Some participants were skeptical about mindfulness. (2) I was able to look at things in a different way: participants described increased meaningful activity, greater awareness of thoughts and emotions and acceptance or adaptation to mobility problems. Some described improvement in the quality of relationships and a sense of feeling free. (3) Treating the body and the mind together: following the intervention participants noted that a holistic approach to healthcare is beneficial. (4) Intervention delivery: The remote delivery was generally seen as helpful for practical reasons and allowed participants to speak openly. Participants voiced a need for follow-up sessions.DiscussionOverall, the intervention was experienced as acceptable. Suggested improvements included de-emphasizing the role of mindfulness and adding follow-up sessions.
Burnout, resilience, and subjective well-being among Portuguese lecturers’ during the COVID-19 pandemic
Authors: Castro Luísa , Serrão Carla , Rodrigues Ana Rita , Marina Sílvia , dos Santos José Paulo Marques , Amorim-Lopes Teresa Sofia , Miguel Carla , Teixeira Andreia , Duarte Ivone 
Published: December 2023

BackgroundLecturers face a large wide of occupational stressors. If the prolonged stress and the symptomatology associated with the working conditions to which lecturers were exposed were already a concern before the pandemic, the pandemic may have exacerbated this psychosocial vulnerability. Burnout is a psychological syndrome that develops in response to chronic work stress. This study aims to describe burnout amongst lecturers working in Portugal and to analyse potential determinants of burnout during the COVID-19 pandemic.MethodsA cross-sectional study was performed using an online questionnaire distributed via social networks. The survey collected sociodemographic and sleep patterns data in addition to applying the Copenhagen Burnout Inventory (personal, work- and student-related burnout), the Resilience Scale, the Depression Anxiety and Stress Scales, and the Satisfaction with Life Scale.ResultsThe sample included 331 lecturers from 35 different colleges and faculties. Three significant models explained personal (R2 = 54%), work- (R2 = 47%) and student- (R2 = 19%) related burnout. Lower levels of resilience and higher levels of depression and stress were significantly associated with personal and work-related burnout. Changes in sleep patterns were additionally associated with both personal and work-related burnout.ConclusionHigher education institutions must recognize the impact of the work environment and organizational culture on faculty mental health and take proactive measures to improve this environment. These institutions can implement support strategies such as educational technology training, professional development programmes, emotional support resources, and workload flexibility. Implementing measures to enhance lecturers’ resilience and overall life satisfaction could potentially help mitigate burnout and improve the well-being of educators, ultimately contributing to the overall quality of education.
Emotional urgency predicts bipolar symptoms, severity, and suicide attempt better than non-emotional impulsivity: a cross-sectional study
Authors: Teh Wen Lin , Liu Jianlin , Chandwani Nisha , Lee Yu Wei , Tor Phern-Chern , Subramaniam Mythily , Ho Roger C. 
Published: December 2023

IntroductionEmotional urgency is an emotion-based subdimension of trait impulsivity that is more clinically relevant to psychopathology and disorders of emotion dysfunction than non-emotional subdimensions (i.e., lack of perseverance, sensation seeking, lack of premeditation). However, few studies have examined the relative effects of emotional urgency in bipolar disorder. This cross-sectional study aimed to establish the clinical relevance of emotional urgency in bipolar disorders by (1) explicating clinically relevant correlates of emotional urgency and (2) comparing its effects against non-emotional impulsivity subdimensions.Methods and resultsA total of 150 individuals with bipolar disorder were recruited between October 2021 and January 2023. Zero-order correlations found that emotional urgency had the greatest effect on bipolar symptoms (r = 0.37 to 0.44). Multiple two-step hierarchical regression models showed that (1) positive urgency predicted past manic symptomology and dysfunction severity (b = 1.94, p &lt; 0.001 and 0.35 p &lt; 0.05, respectively), (2) negative urgency predicted current depression severity, and (3) non-emotional facets of impulsivity had smaller effects on bipolar symptoms and dysfunction by contrast, and were non-significant factors in the final step of all regression models (b &lt; 0.30, ns); Those who had a history of attempted suicide had significantly greater levels of emotional urgency (Cohen’s d = –0.63).DiscussionNotwithstanding the study’s limitations, our findings expand status quo knowledge beyond the perennial relationship between non-emotion-based impulsivity and bipolar disorder and its implications.
Analysis regarding the impact of ‘fake news’ on the quality of life of the population in a region affected by earthquake activity. The case of Romania–Northern Oltenia
Authors: Mărcău Flavius Cristian , Peptan Cătălin , Băleanu Vlad Dumitru , Holt Alina Georgiana , Iana Silviu Adrian , Gheorman Victor 
Published: December 2023

PurposeThe study aims to examine the impact of the wave of seismic activity in the northern region of Oltenia (Gorj County, Romania) in February 2023 and the belief in ‘fake news’ (circulated regarding causality, manifestations, and future developments of the seismic activity) on the quality of life of the affected population. It was considered opportune to conduct this study, given the novelty of such a situation, as the mentioned geographical area is not known to have a high seismic risk.MethodsThe study was built based on the questionnaire to which 975 respondents, present/residing in Gorj County during the earthquakes and at least 14 days after, and with a minimum age of 18 years, responded. The data was collected between February 27, 2023, and March 31, 2023, at a reasonable time interval from the recording of the first seismic event in the region, assuming that the respondents’ opinions regarding the negative impact of seismic events on societal life are well crystallized. The aim was to obtain information and analyze it in order to establish the respondents’ perception regarding the negative effects of seismic activity and the elements of “fake news” promoted in this context on the quality of life of individuals in the region.ResultsOur study indicates that individuals who are not concerned, due to their disbelief in “fake news” information, about the possibility of new strong earthquakes in the mentioned area feel the best physically, having an average satisfaction level of 82.80 (with a standard deviation of 19.70) on the WHOQOL-BREF scale. On the other hand, those who believed in the fake news experienced the lowest levels of psychological well-being, with an average satisfaction of 60.80 (and a standard deviation of 21.98). The WHOQOL-BREF is an instrument that assesses the quality of life across four distinct domains, and this study emphasizes the importance of accurate and trustworthy information for people’s well-being.ConclusionThe results of the study highlight that the quality of life indicators of people in the geographic area affected by the wave of seismic movements are negatively impacted due to the release of “fake news” in the public domain regarding the cause of seismic movements in Gorj county (and the previous earthquakes in Turkey) and their future manifestations and developments (the possibility of high magnitude seismic movements), as well as the lack of information provided by the public authorities on the issue at hand (causes, effects, future manifestations, management measures).