bluuebunny/crossref_metadata_2025_split huggingface dataset:
Praxistaugliches Sprachentwicklungsscreening (SPES) für 2- und 3-jährige Kinder
Authors: Holzinger Daniel , Bergmann Hannah , Habermaier Laura , Fellinger Johannes 
Published: October 2023

ZusammenfassungSprachliche Entwicklungsverläufe stehen in deutlichem Zusammenhang mit der Entwicklung von sozialen Kompetenzen, Beziehungen mit Gleichaltrigen, psychischer Gesundheit, schulischem Lernen und beruflichen Chancen. Eine frühe Erkennung von erhöhtem Risiko für Sprachentwicklungsprobleme erlaubt eine gezielte weitere Abklärung und eine abgestufte Intervention. Die Umsetzung von Sprachförderstrategien in der Familie ist effektiv, in weiterer Folge kann sprachtherapeutische Unterstützung erforderlich sein. In Oberösterreich wurden in langjähriger Forschungsarbeit in der direkten Anwendung in kinderärztlichen Praxen zwei treffsichere und praxistaugliche Sprachscreenings entwickelt, die nun für den Einsatz für 2‑ und 3‑jährige Kinder zur Verfügung stehen. Adaptierungen im Sinne einer Tablet-basierten und somit papierfreien Umsetzung sind in Erprobung. Zudem wird aktuell ein Online-Elterntraining zur frühen Sprachförderung evaluiert.
Metal–Organic Frameworks: Challenges Addressed via Magnetic Resonance Spectroscopy
Authors: Funke Lena Marie , Lund Alicia , Zhuang Hao , Reimer Jeffrey A. 
Published: October 2023

AbstractMagnetic resonance spectroscopies occupy a premier position within the chemical sciences by revealing structure and dynamics in molecules and solids associated with photosynthesis, enzymology, Alzheimer proteins, pharmaceuticals, catalysts, polymers, and electronic materials. Here, we review the recent literature contributions of NMR and EPR spectroscopy towards the study of metal–organic frameworks from 2017 to mid-2022. We organize the review around what we perceive to be the intellectual challenges in MOF research: structure, dynamics, synthesis, properties, and function.
A side-by-side comparison of the new VITEK MS PRIME and the MALDI Biotyper sirius in the clinical microbiology laboratory
Authors: Thelen Philipp , Graeber Sandra , Schmidt Erika , Hamprecht Axel 
Published: October 2023

Abstract
Purpose
This study aims to evaluate the performance of two latest generation matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems in routine laboratory settings, focusing on turnaround time (TAT), time to results (TTR), hands-on time, and identification rate.

Methods
We conducted a time and motion study on three workflow scenarios to simulate different laboratory settings. Overall, 618 bacterial isolates from a tertiary hospital’s laboratory were processed using the VITEK MS PRIME (bioMérieux) and the MALDI Biotyper sirius (Bruker Daltonics) and their corresponding databases VITEK IVD Database 3.2 and MBT reference library 12.

Results
The target preparation process showed no significant difference in TAT, but the Biotyper workflow had a shorter hands-on time by 3 to 6 min. In the measurement process, TTR was three to five times shorter for the Biotyper sirius while hands-on time was significantly shorter for VITEK MS PRIME (approximately 1.5 min per target). The identification rate without retesting was 97.9% for VITEK MS PRIME and 98.9% for Biotyper sirius. Both systems achieved 100% agreement at genus and 96.2% at species level.

Conclusion
Both systems exhibited excellent identification rates for routine bacterial isolates. Due to its high speed, the Biotyper sirius is suited for laboratories with high sample throughput and a workflow designed for processing larger batches. The VITEK MS PRIME, with its “load and go” system accommodating up to 16 targets, reduces hands-on time, making it a reasonable choice for laboratories with fewer identifications overall but a higher number of targets and a workflow designed for parallel processing on different workstations.
Calibrated imputation for multivariate categorical data
Authors: de Waal Ton , Daalmans Jacco 
Published: October 2023

AbstractNon-response is a major problem for anyone collecting and processing data. A commonly used technique to deal with missing data is imputation, where missing values are estimated and filled in into the dataset. Imputation can become challenging if the variable to be imputed has to comply with a known total. Even more challenging is the case where several variables in the same dataset need to be imputed and, in addition to known totals, logical restrictions between variables have to be satisfied. In our paper, we develop an approach for a broad class of imputation methods for multivariate categorical data such that previously published totals are preserved while logical restrictions on the data are satisfied. The developed approach can be used in combination with any imputation model that estimates imputation probabilities, i.e. the probability that imputation of a certain category for a variable in a certain unit leads to the correct value for this variable and unit.
Dispersal in Kentish Plovers (Charadrius alexandrinus): adult females perform furthest movements
Authors: Cimiotti Dominic V. , Eberhart-Hertel Luke , Audevard Aurélien , Garcias Salas Pere Joan , Gelinaud Guillaume , Günther Klaus , Rocha Afonso , Schulz Rainer , van der Winden Jan , Schmaljohann Heiko , Küpper Clemens 
Published: October 2023

AbstractDispersal is an important behavioral process that plays a significant role in, among others, speciation, population viability, and individual fitness. Despite progress in avian dispersal research, there are still many knowledge gaps. For example, it is of interest to study how dispersal propensity relates to age- and/or sex-specific patterns. Here, we investigated the role of sex and life stage on natal (i.e., movement from birth site to first breeding site) and breeding dispersal (i.e., movement between sequential breeding sites) in the Kentish Plover (Charadrius alexandrinus) for dispersal events of more than 10 km. This small and inconspicuous wader is characterized by flexible mating behavior that includes monogamy, and serial polygynandry. Using a continent-wide dataset of ringing and re-encounter data throughout the species’ range in Europe, we found that adult females generally dispersed further than adult males between seasons, but we detected no sex difference in natal dispersal distances and no general difference between natal and breeding dispersal distances. Furthermore, females were the main group exhibiting ‘long-distance’ breeding dispersal, which we defined as dispersal greater than ≥ 108 km, i.e., the upper 10% percentile of our dataset. The data set included dispersal of two females that first bred in the Mediterranean before being detected breeding at the North Sea in the subsequent year, having dispersed 1290 and 1704 km, respectively. These observations represent the longest breeding dispersal observed within the genus Charadrius. Our long-distance dispersal records are consistent with low genetic differentiation between mainland populations shown in previous work. The dispersal of the Kentish Plover is likely linked to its breeding behavior: polyandrous females exhibit extensive mate searching and habitat prospecting. We recommend that the dispersal traits of Kentish Plover be incorporated into the species’ conservation and management planning to more accurately inform models of population connectivity and metapopulation dynamics.
Ground-based climate data show evidence of warming and intensification of the seasonal rainfall cycle during the 1960–2020 period in Yangambi, central Congo Basin
Authors: Kasongo Yakusu Emmanuel , Van Acker Joris , Van de Vyver Hans , Bourland Nils , Mbifo Ndiapo José , Besango Likwela Théophile , Lokonda Wa Kipifo Michel , Mbuya Kankolongo Amand , Van den Bulcke Jan , Beeckman Hans , Bauters Marijn , Boeckx Pascal , Verbeeck Hans , Jacobsen Kim , Demarée Gaston , Gellens-Meulenberghs Françoise , Hubau Wannes 
Published: October 2023

Abstract Meteorological stations are rare in central Africa, which leads to uncertainty in regional climatic trends. This is particularly problematic for the Congo Basin, where station coverage decreased significantly during the last few decades. Here, we present a digitized dataset of daily temperature and precipitation from the Yangambi biosphere reserve, covering the period 1960–2020 (61 years) and located in the heart of the Congo Basin. Our results confirm a long-term increase in temperature and temperature extremes since the 1960s, with strong upward trends since the early 1990s. Our results also indicate a drying trend for the dry season and intensification of the wet season since the early 2000s. Ongoing warming and increasing precipitation seasonality and intensity already have a significant impact on crop yields in Yangambi. This calls for urgent development of climate-smart and dynamic agriculture and agroforestry systems. We conclude that systematic digitization and climate recording in the Congo Basin will be critical to improve much-needed gridded benchmark datasets of climatic variables.
The role and medical prospects of long non-coding RNAs in cardiovascular disease
Authors: Kim Najung , Chung Woo-Young , Cho Je-Yoel 
Published: October 2023

AbstractCardiovascular disease (CVD) has reached epidemic proportions and is a leading cause of death worldwide. One of the long-standing goals of scientists is to repair heart tissue damaged by various forms of CVD such as cardiac hypertrophy, dilated cardiomyopathy, myocardial infarction, heart fibrosis, and genetic and developmental heart defects such as heart valve deformities. Damaged or defective heart tissue has limited regenerative capacity and results in a loss of functioning myocardium. Advances in transcriptomic profiling technology have revealed that long noncoding RNA (lncRNA) is transcribed from what was once considered “junk DNA.” It has since been discovered that lncRNAs play a critical role in the pathogenesis of various CVDs and in myocardial regeneration. This review will explore how lncRNAs impact various forms of CVD as well as those involved in cardiomyocyte regeneration. Further, we discuss the potential of lncRNAs as a therapeutic modality for treating CVD.
Civic Action Against Son Preference in Tirupati, India: Critical International Law Put into Practice?
Authors: Strandberg Hassellind Filip 
Published: October 2023

AbstractIn this paper based on original fieldwork, I seek to contribute to critical scholarship in international law by providing an investigation into the engagement with international law by actors in civil society working against son preference primarily in Tirupati, India. I suggest that the turn to the international legal order by civic actors should be theorized as something else than as merely coming ‘from above’, ‘from below’ or as a ‘translation’ of ‘global’ law to ‘local’ conditions. Instead, I propose that the mobilization of international law within Tirupati’s civil society should be seen as an emancipatory undertaking, an act of resistance with the overarching ambition to reclaim the zenana. In that, I argue, the strategies within Tirupati’s civil society are more appropriately understood as critical international law put into practice.
Application of NMR and Chemometric Analyses to Better Understand the Quality Attributes in pH and Thermally Degraded Monoclonal Antibodies
Authors: Beaumont Victor A. , Liu Lucy , Shi Heliang , Rouse Jason C. , Kim Hai-Young 
Published: October 2023

Abstract
Purpose
Nuclear magnetic resonance (NMR) spectroscopy provides the sensitivity and specificity to probe the higher order structure (HOS) of monoclonal antibodies (mAbs) for potential changes. This study demonstrates an application of chemometric tools to measure differences in the NMR spectra of mAbs after forced degradation relative to the respective unstressed starting materials.

Methods
Samples of adalimumab (Humira, ADL-REF) and trastuzumab (Herceptin, TRA-REF) were incubated in three buffer-pH conditions at 40°C for 4 weeks to compare to a control sample that was left unstressed. Replicate 1D 1H and 2D 1H-13C HMQC NMR spectra were collected on all samples. Chemometric analyses such as Easy Comparability of HOS (ECHOS), PROtein FIngerprinting by Lineshape Enhancement (PROFILE), and Principal Component Analysis (PCA) were applied to capture and quantitate differences between the spectra.

Results
Visual and statistical inspection of the 2D 1H-13C HMQC spectra of adalimumab and trastuzumab after forced degradation conditions shows no changes in the spectra relative to the unstressed material. Chemometric analysis of the 1D 1H NMR spectra shows only minor changes in the spectra of adalimumab after forced degradation, but significant differences in trastuzumab.

Conclusion
The chemometric analyses support the lack of statistical differences in the structure of pH-thermal stressed adalimumab, however, it reveals conformational changes or chemical modifications in trastuzumab after forced degradation. Application of chemometrics in comparative NMR studies enables HOS characterization and showcases the sensitivity and specificity in detecting differences in the spectra of mAbs after pH-thermal forced degradation with respect to local and global protein structure.
Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2
Authors: Lignet Floriane , Friese-Hamim Manja , Jaehrling Frank , El Bawab Samer , Rohdich Felix 
Published: October 2023

Abstract
Introduction
M8891 is a selective and reversible inhibitor of methionine aminopeptidase 2 (MetAP2). We describe translational research to define the target pharmacokinetics (PK) of M8891 and associated pharmacodynamic (PD) levels, which were used to support efficacious dose selection in humans.

Methods
In vitro and in vivo PK characteristics were investigated in animal species, and data integrated using in vitro–in vivo correlation and allometric methods to predict the clearance, volume of distribution, and absorption parameters of M8891 in humans. In parallel, inhibition of MetAP2 activity by M8891 was studied in renal cancer xenografts in mice by measuring accumulation of Met-EF1α, a substrate of MetAP2. The corresponding PD effect was described by a turnover and effect compartment model. This model was used to simulate PD at the M8891 dose showing in vivo efficacy, i.e. significant tumor growth inhibition. Simulations of M8891 PK and associated PD in humans were conducted by integrating predicted human PK parameters into the preclinical PK/PD model.

Results
The target minimum PD level associated with efficacy was determined to be 125 µg Met-EF1α per mg protein. Integrating predicted human PK parameters into the preclinical PK/PD model defined a minimal M8891 concentration at steady-state (Ctrough) of 1500 ng/mL (3.9 µM) in humans as being required to produce the corresponding minimum target Met-EF1a level (125 µg per mg protein).

Conclusion
The defined target PK and PD levels supported the design of the clinical Phase Ia dose escalation study of M8891 (NCT03138538) and selection of the recommended Phase II dose.
Dimensional Analysis and Stage-Discharge Relationships for Vegetated Weirs
Authors: Nicosia Alessio , Di Stefano Costanza , Serio Maria Angela , Ferro Vito 
Published: October 2023

AbstractThe deduction of the weir flow stage-discharge relationship is a hydraulic problem generally solved by energy considerations and using the discharge coefficient to correct the gap between theoretical results and experimental measurements. In this context, the dimensional analysis represents an alternative to find simple and reliable equations to obtain the rating curve. In this study, the outflow process of vegetated weirs is investigated applying the Π-Theorem of dimensional analysis and the incomplete self-similarity theory. The aim of this paper is to propose a new theoretically-based stage-discharge relationship, and test its applicability by measurements recently published in the literature. The results showed that the errors in discharge estimate obtained by the proposed stage-discharge relationship are always less than or equal to ± 10% and less than or equal to ± 5% for 97–100% of cases. The main advantage of the proposed relationships is providing a single stage-discharge relationship, which has better performances than the equations reported in the literature and excludes the use of discharge coefficient.
Auswirkungen des Zugangs zum Homeoffice auf die Erwerbsarbeitszeiten von Müttern und Vätern
Authors: Pauliks Johanna Elisabeth , Schunck Reinhard , Lott Yvonne 
Published: October 2023

ZusammenfassungDieser Beitrag geht der Frage nach, wie sich die tatsächliche Arbeitszeit von Müttern und Vätern verändert, wenn sie die Möglichkeit erhalten, im Homeoffice zu arbeiten. Ausgehend von der Principle-Agent-Theorie, der sozialen Austauschtheorie und der Work/Family-Border-Theorie wurde mit längsschnittlichen Daten des deutschen Beziehungs- und Familienpanels (pairfam) geprüft, ob eine Veränderung der tatsächlichen Arbeitszeit zu beobachten ist, wenn die Möglichkeit besteht, im Homeoffice zu arbeiten. Um mögliche Selektionseffekte auszuschließen, wurden sowohl konventionelle Fixed-Effects- als auch Fixed-Effects-Individual-Slope-Modelle zur Schätzung des Effekts vom Zugang zu Homeoffice auf die Arbeitszeit von Vätern und Müttern verwendet. Bei Vätern sind die geschätzten Zusammenhänge zwischen dem Zugang zum Homeoffice und der tatsächlichen Arbeitszeit klein und statistisch nicht signifikant. Bei Müttern zeigen sich positive, substanzielle und – in Abhängigkeit von der Modellspezifikation – statistisch signifikante Zusammenhänge.
Transitioning from One Electronic Health Record to Another: A Systematic Review
Authors: Miake-Lye Isomi M , Cogan Alison M. , Mak Selene , Brunner Julian , Rinne Seppo , Brayton Catherine E. , Krones Ariella , Ross Travis E. , Burton Jason T. , Weiner Michael 
Published: October 2023

Abstract
Background
Transitioning to a new electronic health record (EHR) presents different challenges than transitions from paper to electronic records. We synthesized the body of peer-reviewed literature on EHR-to-EHR transitions to evaluate the generalizability of published work and identify knowledge gaps where more evidence is needed.

Methods
We conducted a broad search in PubMed through July 2022 and collected all publications from two prior reviews. Peer-reviewed publications reporting on data from an EHR-to-EHR transition were included. We extracted data on study design, setting, sample size, EHR systems involved, dates of transition and data collection, outcomes reported, and key findings.

Results
The 40 included publications were grouped into thematic categories for narrative synthesis: clinical care outcomes (n = 15), provider perspectives (n = 11), data migration (n = 8), patient experience (n = 4), and other topics (n = 5). Many studies described single sites that are early adopters of technology with robust research resources, switching from a homegrown system to a commercial system, and emphasized the dynamic effect of transitioning on important clinical care and other outcomes over time.

Discussion
The published literature represents a heterogeneous mix of study designs and outcome measures, and while some of the stronger studies in this review used longitudinal approaches to compare outcomes across more sites, the current literature is primarily descriptive and is not designed to offer recommendations that can guide future EHR transitions. Transitioning from one EHR to another constitutes a major organizational change that requires nearly every person in the organization to change how they do their work. Future research should include human factors as well as diverse methodological approaches such as mixed methods and implementation science.
“Everything’s so Role-Specific”: VA Employee Perspectives’ on Electronic Health Record (EHR) Transition Implications for Roles and Responsibilities
Authors: Ahlness Ellen A. , Orlander Jay , Brunner Julian , Cutrona Sarah L. , Kim Bo , Molloy-Paolillo Brianne K. , Rinne Seppo T. , Rucci Justin , Sayre George , Anderson Ekaterina 
Published: October 2023

Abstract
Background
Electronic health record (EHR) transitions are increasingly widespread and often highly disruptive. It is imperative we learn from past experiences to anticipate and mitigate such disruptions. Veterans Affairs (VA) is undergoing a large-scale transition from its homegrown EHR (CPRS/Vista) to a commercial EHR (Cerner), creating a unique opportunity of shedding light on large-scale EHR-to-EHR transition challenges.

Objective
To explore one facet of the organizational impact of VA’s EHR transition: its implications for employees’ roles and responsibilities at the first VA site to implement Cerner Millennium EHR.

Design
As part of a formative evaluation of frontline staff experiences with VA’s EHR transition, we conducted brief (~ 15 min) and full-length interviews (~ 60 min) with clinicians and staff at Mann-Grandstaff VA Medical Center in Spokane, WA, before, during, and after transition (July 2020-November 2021).

Participants
We conducted 111 interviews with 26 Spokane clinicians and staff, recruited via snowball sampling.

Approach
We conducted audio interviews using a semi-structured guide with grounded prompts. We coded interview transcripts using a priori and emergent codes, followed by qualitative content analysis.

Key Results
Unlike VA’s previous EHR, Cerner imposes additional restrictions on access to its EHR functionality based upon “roles” assigned to users. Participants described a mismatch between established institutional duties and their EHR permissions, unanticipated changes in scope of duties brought upon by the transition, as well as impediments to communication and collaboration due to different role-based views.

Conclusions
Health systems should anticipate substantive impacts on professional workflows when EHR role settings do not reflect prior workflows. Such changes may increase user error, dissatisfaction, and patient care disruptions. To mitigate employee dissatisfaction and safety risks, health systems should proactively plan for and communicate about expected modifications and monitor for unintended role-related consequences of EHR transitions, while vendors should ensure accurate role configuration and assignment.