bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal tooth maturation associated with port wine stains
Authors: Liu Zhixu , Ying Hanru , Lin Xiaoxi , Wang Xudong , Zhao Jing , Zhu Min , Yang Xiao 
Published: December 2023

AbstractObjectiveThis study aims to evaluate the potential impact of port wine stains on the development of permanent teeth in mixed dentition and provide insights for managing tooth abnormalities in patients with port wine stains.Materials and MethodsA retrospective analysis was conducted on 21 patients with mixed dentition and unilateral maxillary port wine stains. Two researchers concurrently utilized Nolla Analysis to assess the developmental stage of bilateral maxillary and permanent mandibular teeth based on panoramic radiographs. The cumulative developmental values of upper and lower permanent teeth on both sides were calculated, and a comparison was made between the developmental stages of the upper and lower jaws.ResultsPort wine stains can influence the maturity of permanent upper teeth, within the unilateral maxillary port wine stains range, with an early developmental completion observed on the affected side compared to the unaffected side. While the developmental stages of the lower teeth on both sides showed similarities.ConclusionsPort wine stains can accelerate the maturity of teeth on the affected side, leading to alterations in the order of tooth eruption and subsequent abnormal occlusion in children with mixed dentition. These findings provide a basis for developing appropriate management strategies for addressing tooth abnormalities in patients with port wine stains.
Unanticipated difficult airway after prolonged use of a laryngeal mask airway
Authors: Lorente Claudia , Kiss Edgar , Kastner Galit , Dariya Vedanta Singh , Olomu Patrick , Szmuk Peter 
Published: December 2023

AbstractThe laryngeal mask airway (LMA) is recognized as a safe alternative to endotracheal intubation for short‐term airway maintenance. In this case report we present the case of a term neonate with upper airway obstruction which was managed with a deflated LMA for 7 consecutive days. Despite previous reports of extended LMA use in neonates without complications, this patient experienced significant pharyngeal mucosal injury and edema, leading to difficulty with subsequent intubation attempts.
Cardiac magnetic resonance imaging in detection of progressive graft dysfunction in pediatric heart transplantation
Authors: Watanabe Kae , Arva Nicoleta C. , Robinson Joshua D. , Rigsby Cynthia , Markl Michael , Sojka Melanie , Tannous Paul , Arzu Jennifer , Husain Nazia 
Published: December 2023

AbstractBackgroundChronic graft failure (CGF) in pediatric heart transplant (PHT) is multifactorial and may present with findings of fibrosis and microvessel disease (MVD) on endomyocardial biopsy (EMB). There is no optimal CGF surveillance method. We evaluated associations between cardiac magnetic resonance imaging (CMR) and historical/EMB correlates of CGF to assess CMR's utility as a surveillance method.MethodsRetrospective analysis of PHT undergoing comprehensive CMR between September 2015 and January 2022 was performed. EMB within 6 months was graded for fibrosis (scale 0–5) and MVD (number of capillaries with stenotic wall thickening per field of view). Correlation analysis and logistic regression were performed.ResultsForty‐seven PHT with median age at CMR of 15.7 years (11.6, 19.3) and time from transplant of 6.4 years (4.1, 11.0) were studied. Cardiac allograft vasculopathy (CAV) was present in 11/44 (22.0%) and historical rejection in 14/41 (34.2%). CAV was associated with higher global T2 (49.0 vs. 47.0 ms; p = 0.038) and peak T2 (57.0 vs. 53.0 ms; p = 0.013) on CMR. Historical rejection was associated with higher global T2 (49.0 vs. 47.0 ms; p = 0.007) and peak T2 (57.0 vs. 53.0 ms; p = 0.03) as well as global extracellular volume (31.0 vs. 26.3%; p = 0.03). Higher fibrosis score on EMB correlated with smaller indexed left ventricular mass (rho = −0.34; p = 0.019) and greater degree of MVD with lower indexed left ventricular end‐diastolic volume (rho = −0.35; p = 0.017).ConclusionAdverse ventricular remodeling and abnormal myocardial characteristics on CMR are present in PHT with CAV, historical rejection, as well as greater fibrosis and MVD on EMB. CMR has the potential use for screening of CGF.
Changes over time in self‐efficacy and the allocation of responsibility for health management tasks in pediatric liver transplant recipients: Targets to improve the transition process
Authors: Bilhartz Jacob L. , Lopez M. James , Eder Sally J. , Magee John C. , Rea Kelly , Sturza Julie , Fredericks Emily M. 
Published: December 2023

AbstractBackgroundThe process of transition to adult‐based care encompasses a critical period in the life of an adolescent and young adult living with a chronic illness and one that comes with an increase in the risk of poor health outcomes. As yet, there is a dearth of empirical data to help optimize this process to ensure the best long‐term outcome.MethodsThis study used a principal components analysis to determine specific constructs measured by a revised version of the transition readiness survey used in our clinic. We investigated changes in these constructs over time. We further investigated the relationship between the change in these constructs over time spent in a focused transition program with adherence.ResultsThe primary component underlying our transition readiness survey for patients and parents represented self‐efficacy. Time spent in the transition program was an independent predictor of change in self‐efficacy (rho 0.299, p = .015); however, the magnitude of that change had no relationship to adherence. Change in parent‐proxy self‐efficacy was found to have a statistically significant relationship with tacrolimus standard deviation (rho −0.301, p = .026). There was disagreement identified between patient and parent responses on the survey. Neither change in patient nor parent reports of self‐efficacy was found to have a relationship with post‐transfer adherence.ConclusionsThis study reaches the novel conclusion that self‐efficacy and parent‐proxy self‐efficacy are dynamic concepts that change over time spent in a focused transition program. The patient‐parent disagreement and the relationship between parent‐proxy self‐efficacy and adherence stress the importance of involving parents/guardians in the transition process as well.
The safety and effectiveness of a self‐made negative pressure suction device in the treatment of chronic wounds
Authors: Wang He‐Ping , Hu Xiu‐Li , Zhou Hua‐Qin , Chen Xi‐Shan , Wang Meng‐Xin 
Published: December 2023

AbstractIntroductionChronic wounds are wounds that are not healed or have no healing tendency for more than 1 month due to various factors. In clinical nursing, chronic wounds are often not properly treated, and the treatment efficiency is low. Therefore, it is very important to explore effective methods to deal with chronic wounds.ObjectiveTo explore the effect of a self‐made negative pressure suction device (NPSD) in the nursing of chronic wounds in the elderly.MethodsA total of 50 elderly patients with chronic wounds who were hospitalised in our hospital from January 2020 to December 2022 were selected as participants by convenient sampling. According to the random number table method, they were divided into a control group and an observation group, with 25 people in each group. The control group was treated with chloroplast foam dressing, debridement gel and alginate dressing. The observation group was treated with a self‐made NPSD on the basis of the control group. The wound healing of the two groups was observed.ResultsAfter the intervention of the self‐made NPSD, the granulation tissue coverage rate and wound volume reduction rate of the observation group were significantly increased (p < 0.05), and the positive rate of bacterial infection was significantly decreased (p < 0.05). After 3 months of intervention, the total effective rate of the observation group was significantly higher than that of the control group (χ2 = 3.869, p = 0.0492).ConclusionThe self‐made NPSD can effectively promote the healing of a chronic wound.
Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure
Authors: Bunsawat Kanokwan , Nelson Michael D. , Hearon Christopher M. , Wray D. Walter 
Published: December 2023

AbstractHeart failure with preserved ejection fraction (HFpEF) accounts for over 50% of all heart failure cases nationwide and continues to rise in its prevalence. The complex, multi‐organ involvement of the HFpEF clinical syndrome requires clinicians and investigators to adopt an integrative approach that considers the contribution of both cardiac and non‐cardiac function to HFpEF pathophysiology. Thus, this symposium review outlines the key points from presentations covering the contributions of disease‐related changes in cardiac function, arterial stiffness, peripheral vascular function, and oxygen delivery and utilization to exercise tolerance in patients with HFpEF. While many aspects of HFpEF pathophysiology remain poorly understood, there is accumulating evidence for a decline in vascular health in this patient group that may be remediable through pharmacological and lifestyle interventions and could improve outcomes and clinical status in this ever‐growing patient population.
Physical Activity and Children’s Episodic Memory: A Meta-Analysis
Authors: Schmid Daphne G. , Scott Nathan M. , Tomporowski Phillip D. 
Published: December 2023

Purpose: The purpose of this review was to evaluate the effects of physical activity on children’s free recall, cued recall, and recognition episodic memory and to explore potential moderating factors. Methods: The following databases were searched: PubMed, ERIC, APA Psych Info, CINHAL, SPORTDiscus, and Google Scholar. Studies were included if: (1) participants were aged 4–18 years, (2) participants were typically developed, (3) participants were randomized to groups, (4) interventions employed gross movements, (5) sedentary group was used for control, (6) memory tests were quantitative, and (7) employed acute or chronic intervention. Results: 14 studies met inclusion criteria resulting in the analysis of data from 7 free recall, 7 cued recall, and 8 recognition memory tests. Physical activity was found to have a positive influence on tests free (g = 0.56), cued recall (g = 0.67), and no influence on tests of recognition (g = 0.06). While some moderator analyses were significant, the authors do not consider these results to be meaningful in application. Conclusions: The effects of acute and chronic physical activity enhance specific aspects of long-term episodic memory. These findings suggest physical activity interventions developed for children may be expected to benefit some, but not all, types of memory processing.
Pan-antiviral effects of a PIKfyve inhibitor on respiratory virus infection in human nasal epithelium and mice
Authors: Baker Jonathan , Ombredane Hugo , Daly Leah , Knowles Ian , Rapeport Garth , Ito Kazuhiro 
Published: December 2023

ABSTRACT

Endocytosis, or internalization through endosomes, is a major cell entry mechanism used by respiratory viruses. Phosphoinositide 5-kinase (PIKfyve) is a critical enzyme for the synthesis of phosphatidylinositol (3, 5)biphosphate (PtdIns (3, 5)P2) and has been implicated in virus trafficking
via
the endocytic pathway. In fact, antiviral effects of PIKfyve inhibitors against SARS-CoV-2 and Ebola have been reported, but there is little evidence regarding other respiratory viruses. In this study, we demonstrated the antiviral effects of PIKfyve inhibitors on influenza virus and respiratory syncytial virus
in vitro
and
in vivo
. PIKfyve inhibitors Apilimod mesylate (AM) and YM201636 concentration-dependently inhibited several influenza strains in an MDCK cell-cytopathic assay. AM also reduced the viral load and cytokine release, while improving the cell integrity of human nasal air-liquid interface cultured epithelium infected with influenza PR8. In PR8-infected mice, AM (2 mg/mL), when intranasally treated, exhibited a significant reduction of viral load and inflammation and inhibited weight loss caused by influenza infection, with effects being similar to oral oseltamivir (10 mg/kg). In addition, AM demonstrated antiviral effects in RSV A2-infected human nasal epithelium
in vitro
and mouse
in vivo
, with an equivalent effect to that of ribavirin. AM also showed antiviral effects against human rhinovirus and seasonal coronavirus
in vitro
. Thus, PIKfyve is found to be involved in influenza and RSV infection, and PIKfyve inhibitor is a promising molecule for a pan-viral approach against respiratory viruses.
Draft genome sequence of an
Atlantibacter hermannii
clinical strain isolated from human muscle tissue
Authors: Feng Yan , Feng Yu , Zong Zhiyong 
Published: December 2023

ABSTRACT

Atlantibacter hermannii
is a species of the family
Enterobacteriaceae
and a rare opportunistic pathogen. The draft genome sequence of an
Atlantibacter hermannii
clinical strain that had been isolated from infected muscle tissue was obtained. The genome contains about 4.4 million bases and has no known plasmid replicons.
The draft genome sequence of
bla
IMP-4
-carrying
Enterobacter soli
isolated from human blood
Authors: Feng Yu , Zong Zhiyong 
Published: December 2023

ABSTRACT

Enterobacter soli
is a Gram-negative rod characterized by its motile, non-spore-forming, and facultatively anaerobic nature. In this study, strain 140044, identified as
Enterobacter soli
, was isolated from human blood. The strain was sequenced, revealing a 5.37-Mb draft genome harboring the carbapenemase gene
bla
IMP-4
.
Draft genome sequence of
Acidiplasma cupricumulans
strain BH2
T
, isolated from a pregnant leachate solution of heap bioleaching
Authors: Bulaev Aleksandr G. , Kanygina Aleksandra V. , Mardanov Andrey V. 
Published: December 2023

ABSTRACT

We report the draft genome sequence of a type strain
Acidiplasma cupricumulans
Strain BH2
T
, isolated from a pregnant leachate solution of industrial-scale chalcocite bioleach heap (Monywa, Myanmar). The genome is 1.7 Mbp long with a GC content of 34.2%.
Whole genome sequences of
Lactococcus lactis
KCKM 0851 isolated from green onion kimchi
Authors: Ko Hye In , Kim So-Rim , Jeong Chae-Rim , Lee Mo Eun , Eun Jong-Bang , Kim Tae-Woon 
Published: December 2023

ABSTRACT

Lactococcus lactis
KCKM 0851 isolated from green onion kimchi is a probiotic candidate and can be used as a starter culture for kimchi and dairy products. The whole-genome data of this strain will help us understand its genetics and metabolic characteristics.
Mass spectrometry imaging of natural carbonyl products directly from agar-based microbial interactions using 4-APEBA derivatization
Authors: Veličković Dušan , Zemaitis Kevin J. , Bhattacharjee Arunima , Anderton Christopher R. 
Published: December 2023

ABSTRACT

Aliphatic carboxylic acids, aldehydes, and ketones play diverse roles in microbial adaptation to their microenvironment, from excretion as toxins to adaptive metabolites for membrane fluidity. However, the spatial distribution of these molecules throughout biofilms and how microbes in these environments exchange these molecules remain elusive for many of these bioactive species due to inefficient molecular imaging strategies. Herein, we apply on-tissue chemical derivatization (OTCD) using 4-(2-((4-bromophenethyl)dimethylammonio)ethoxy)benzenaminium dibromide (4-APEBA) on a co-culture of a soil bacterium (
Bacillus subtilis
NCIB 3610) and fungus (
Fusarium
sp. DS 682) grown on agar as our model system. Using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), we spatially resolved more than 300 different metabolites containing carbonyl groups within this model system. Various spatial patterns are observable in these species, which indicate possible extracellular or intercellular processes of the metabolites and their up- or downregulation during microbial interaction. The unique chemistry of our approach allowed us to bring additional confidence in accurate carbonyl identification, especially when multiple isomeric candidates were possible, and this provided the ability to generate hypotheses about the potential role of some aliphatic carbonyls in this
B. subtilis
/
Fusarium
sp. interaction. The results shown here demonstrate the utility of 4-ABEBA-based OTCD MALDI-MSI in probing interkingdom interactions directly from microbial co-cultures, and these methods will enable future microbial interaction studies with expanded metabolic coverage.

IMPORTANCE

The metabolic profiles within microbial biofilms and interkingdom interactions are extremely complex and serve a variety of functions, which include promoting colonization, growth, and survival within competitive and symbiotic environments. However, measuring and differentiating many of these molecules, especially in an
in situ
fashion, remains a significant analytical challenge. We demonstrate a chemical derivatization strategy that enabled highly sensitive, multiplexed mass spectrometry imaging of over 300 metabolites from a model microbial co-culture. Notably, this approach afforded us to visualize over two dozen classes of ketone-, aldehyde-, and carboxyl-containing molecules, which were previously undetectable from colonies grown on agar. We also demonstrate that this chemical derivatization strategy can enable the discrimination of isobaric and isomeric metabolites without the need for orthogonal separation (e.g., online chromatography or ion mobility). We anticipate that this approach will further enhance our knowledge of metabolic regulation within microbiomes and microbial systems used in bioengineering applications.
Progression of the FIB-4 index among patients with chronic HCV infection and early liver disease
Authors: Krassenburg Lisette A P , Maan Raoel , Puenpatom Amy , Erler Nicole S , Welsch Christoph , van Hees Stijn , Cerrhoci Orlando , Vermehren Johannes , de Knegt Robert J , Hansen Bettina E , Zeuzem Stefan , Vanwolleghem Thomas , Janssen Harry L A , de Man Robert A , Feld Jordan J , van der Meer Adriaan J 
Published: December 2023

Background and aimsHistorical paired liver biopsy studies are likely to underestimate current progression of disease in patients with chronic hepatitis C virus (HCV) infection. We aimed to assess liver disease progression according to the non-invasive Fibrosis-4 (FIB-4) index in patients with chronic HCV and early disease.Methods and resultsPatients diagnosed with chronic HCV and FIB-4 <3.25 from four international liver clinics were included in a retrospective cohort study. Follow-up ended at start of antiviral therapy resulting in sustained virological response, at time of liver transplantation or death. Primary outcome of advanced liver disease was defined as FIB-4 >3.25 during follow-up. Survival analyses were used to assess time to FIB-4 >3.25.In total, 4286 patients were followed for a median of 5.0 (IQR 1.7–9.4) years, during which 41 071 FIB-4 measurements were collected. At baseline, median age was 47 (IQR 39–55) years, 2529 (59.0%) were male, and 2787 (65.0%) patients had a FIB-4 <1.45. Advanced liver disease developed in 821 patients. Overall, 10-year cumulative incidence of advanced disease was 32.1% (95% CI 29.9% to 34.3%). Patients who developed advanced disease showed an exponential FIB-4 increase. Among patients with a presumed date of HCV infection, cumulative incidence of advanced disease increased 7.7-fold from 20 to 40 years as opposed to the first 20 years after HCV infection.ConclusionsThe rate of advanced liver disease is high among chronic HCV-infected patients with early disease at time of diagnosis, among whom liver disease progression accelerated over time. These results emphasise the need to overcome any limitations with respect to diagnosing and treating all patients with chronic HCV across the globe.
Healthcare professionals’ intention to adopt mobile phone-based SMS and its predictors for adherence support and care of TB patients in a resource-limited setting: a structural equation modelling analysis
Authors: Walle Agmasie Damtew , Hunde Mekonnen Kenate , Demsash Addisalem Workie 
Published: December 2023

ObjectiveTo assess healthcare providers’ intentions and the associated factors to use mobile phone-based short message service (SMS) to support adherence and care of tuberculosis (TB) patients in the Oromia region of southwest Ethiopia.Study designAn institutional-based cross-sectional study was conducted from October to November 2022.Study settingThe study was conducted in public hospitals which include Mettu Karl referral hospital, Dembi Hospital, Bedelle Hospital, Darimu Hospital and Chora Hospital in Ilu Aba Bor and Buno Bedelle zones.ParticipantsA total of 625 (54.9% male and 45.1% female) health professionals participated in the study. The study participants were selected using a simple random sampling technique. All health professionals permanently working in Ilu Aba Bor and Buno Bedelle zone hospitals were included in this study. However, health professionals with less than 6 months of experience and those who were not present during the data collection period were excluded from this study.Outcome measureThe intention to use mobile phone-based SMS to support TB patients.ResultsHealthcare professionals’ intention to use mobile SMS was 54.4%. Effort expectancy had a significant direct effect on attitude (β=0.162, p<0.01) and intention towards using mobile phone SMS (β=0.329, p<0.001). The intention to use mobile phone SMS was directly influenced by facilitating conditions (β=0.104, p<0.01) and attitude (β=0.26, p<0.001). The relationship between effort expectancy and intention to use SMS was mediated by attitude (β=0.043, p<0.01).ConclusionsOverall, intention to use of mobile-based SMS was high. Effort expectancy, attitude and facilitating conditions were significant factors that determined healthcare professionals’ behavioural intention to use mobile phone SMS. Effort expectancy had a more significant prediction power than others. As a result, system forms that are easily interactive and applicable should be implemented to improve capacity building and support the adherence and care of TB patients.