bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulation of gut microbiota exacerbates LPS-induced endometritis by producing succinate in mice
Authors: Fu Yunhe , Qiu Min , zhao Xiaotong , Xie Jiaxin , cheng Qian , Liu Yiheng , Zhao Caijun , Zhang Naisheng , Hu Xiaoyu 
Published: February 2024

Abstract
There is increasing evidence suggesting a connection between the gut microbiota and female reproductive diseases, including endometritis. Endometritis not only poses higher health risks to women but also incurs significant economic costs in animals. However, the impact of gut inflammation on the gut microbiota and its role in the development of endometritis is still uncertain. This study aimed to investigate the effects of intestinal microbiota on LPS-induced endometritis in mice. Our findings demonstrate that DSS-induced intestinal inflammation can worsen LPS-induced endometritis in mice, and this effect is dependent on the gut microbiota, as the use of antibiotics to deplete the gut microbiota eliminates this protective effect. Similarly, fecal microbiota transplantation (FMT) from DSS-treated mice (DF) to recipient mice exacerbates LPS-induced endometritis. Furthermore, the depletion of DSS and DF leads to increased levels of fecal succinate compared to controls. Additionally, treatment with succinic acid aggravates LPS-induced endometritis in mice. Mechanistically, depletion of DSS treatment resulted in disruption of the gut barrier and an imbalance of succinate-producing and succinate-consuming bacteria. This imbalance led to the massive production, blood transport, and accumulation of succinate in the uterus via the gut-uterus axis. Consequently, the uterine injury was exacerbated through intestinal succinate, which exacerbates uterine injury by SUCNR 1-dependent promotion of NF-κB activation. Overall, our findings suggest that dysbiosis of the gut microbiota exacerbates LPS-induced endometritis in mice by gut microbiota producing succinate. This identifies gut-derived succinate as a novel target for treating critical endometritis. Furthermore, it indicates that targeting the gut microbiota and its metabolism could be a potential strategy for intervention in endometritis and other infectious diseases.
Evaluating human landing catches as a measure of mosquito biting and the importance of considering additional modes of action
Authors: Fairbanks Emma , Tambwe Mgeni , Moore Jason , Mpelepele Ahmed , Lobo Neil , Mashauri Rajabu , Chitnis Nakul , Moore Sarah 
Published: February 2024

Abstract
Entomological evaluations of vector control tools often use human landing catches (HLCs) as a standard measure of a direct human-vector contact. However, some tools have additional characteristics, such as mortality, and HLCS are not sensitive for measuring other effects beyond landing inhibition. Therefore, additional measures may need to be considered when evaluating these tools for public health use. This study has two main aims (1) the evaluate the accuracy of HLCs as a proxy for feeding and (2) to compare the predicted reduction in vectorial capacity when we do and do not consider these additional characteristics. To achieve this, we analyse previously published semi-field data from an experiment which used HLCs and another where mosquitoes were allowed to feed in the presence of different dosages of the volatile pyrethroid spatial repellent, transfluthrin. We compare results for two mathematical models: one which only considers the reduction in feeding effect and one which also considers mortality before and after feeding (using data gathered by the aspiration of mosquitoes after the semi-field feeding/landing period and 24 hour survival monitoring). These Bayesian hierarchical models are parameterised using Bayesian inference. We observe that, for susceptible mosquitoes, reduction in landing is underestimated by HLCs. For knockdown resistant mosquitoes the relationship is less clear; with HLCs sometimes appearing to overestimate this characteristic. We find HLCs tend to under-predict the relative reduction in vectorial capacity in susceptible mosquitoes while over-predicting this impact in knockdown-resistant mosquitoes. Models without secondary effects have lower predicted relative reductions in vectorial capacities. Overall, this study highlights the importance of considering additional characteristics to reduction in biting of volatile pyrethroid spatial repellents. We recommend that these are considered when evaluating novel vector control tools.
Mendelian randomization of leisure sedentary behavior, physical activity and scoliosis
Authors: Fangjun Yang 
Published: February 2024

Abstract
Objective: To investigate the relationship between leisure sedentary behavior (LSB), physical activity (PA) and the risk of scoliosis by using two-sample Mendelian randomization (MR).
Methods: Genetic variation in television watching time, mobile phone use time, moderate-to-high intensity physical activity (MVPA), and vigorous physical activity (VPA) were used as instrumental variables, and genome-wide association data from a Finnish database of patients with scoliosis were used. The inverse variance weighting (IVW) method was used as the main analysis method, and the weighted median, MR-Egger, MR Multi-effect residual sum and outlier were combined to perform multiple sensitivity analysis.
Results: IVW results showed: watching TV time (OR=0.623, 95%CI: 0.616-1.789, P=0.623); Time spent on mobile phones (OR=0.575, 95%CI: 0.169-1.960, P=0.377); MVPA (OR=0.535, 95%CI: 0.09-3.15, P=0.49); VPA (OR=0.623, 95%CI: 0.616-1.789, P=0.623). The results of the primary IVW MR Analysis were consistent with those of the multiple sensitivity MR Analysis.
Conclusion: Genetic susceptibility to leisure sedentary behavior and physical activity are not associated with the risk of scoliosis. The observed associations may be the result of shared genetic effects or environmental confounding factors. However, we found a possible correlation between the type of physical activity and scoliosis.
The application of a single-hand-operated hepatic pedicle clamping clamp in laparoscopic hepatectomy
Authors: Shen Zhengchao , Jiang Bin , CHU Hongpeng , WANG Guannan , FANG Xiaosan , CHEN Zhiyuan , YANG Yuntao , WANG Jie , WANG Xiaoming 
Published: February 2024

Abstract

Objective
In this paper, a single-hand-operated hepatic pedicle clamp was introduced, and its application value in laparoscopic liver tumor resection was preliminarily discussed.
Methods
The clinical data of 67 patients who underwent laparoscopic liver tumor resection at the First Affiliated Hospital of Wannan Medical College from March 2019 to October 2023 were retrospectively analyzed. The Pringle maneuver was performed with a hepatic pedicle clamp during the operation. The preoperative, intraoperative and postoperative clinical data were observed and recorded.
Results
Sixty-seven patients had a median block number, block time, intraoperative blood loss, and postoperative length of hospital stay of 4, 55 min, 400 ml, and 7 days, respectively. The average operation time was 304.9 ± 118.4 min, the time required for each block was 3.2 ± 2.4 s, and the time required for each removed block was 2.6 ± 0.7 s. None of the patients developed portal vein thrombosis or hepatic artery aneurysm formation. The median postoperative hospital stay was 7 (3–21) days.
Conclusion
The hepatic pedicle clamping clamp is simple to use in laparoscopic hepatectomy, optimizes the operation process, and has a reliable blocking effect. It is recommended for clinical application.
Immediate impacts of wildfires on ground-dwelling macroinvertebrate communities under stones in Mediterranean oak forests
Authors: Puga João R. L. , Moreira Francisco , Keizer Jan J. , Abrantes Nelson J. C. 
Published: February 2024

Abstract
Wildfires are considered a major disturbance to forest ecosystems in the Mediterranean countries of Southern Europe. Although ground-dwelling macroinvertebrates are crucial to many soil functions, there is a fundamental lack of understanding of how wildfires impact this community in the immediate term and of the role of stones in their survival. Hence, in the present study, we assessed the immediate effects of wildfires in the ground-dwelling macroinvertebrate community found under stones by comparing communities in burnt and non-burnt Mediterranean oak forests. Our results revealed that stones allowed the survival of many taxa in the burnt area. However, abundance, richness, diversity, and equitability per stone were significantly lower at the burnt than unburnt sites. Furthermore, the results also showed that richness and abundance increased significantly with increasing stone depth and area at the burnt and unburnt sites. Significant changes at the trophic level were observed in the burnt area compared to the unburnt, particularly a decline in predators. No significant differences were identified concerning habitat associations among taxa. Overall, this study stressed the role of stones as microhabitats and refuge for the ground-dwelling macroinvertebrate community during wildfires.
Finitely presented subgroups of direct products of graphs of groups with free abelian vertex groups
Authors: Casals-Ruiz Montserrat , Zearra Jone Lopez de Gamiz 
Published: February 2024

Abstract
In this paper, we study the relation between the finiteness properties of subgroups of direct products of 2-dimensional coherent right-angled Artin groups with their structure and the decidability of algorithmic problems. More precisely, we show that a finitely presented subgroup S of the direct product of 2-dimensional coherent RAAGs is virtually a nilpotent extension of a direct product. Moreover, if S is of type FP, then S is commensurable to a kernel of a character. We use these results to show that the multiple conjugacy problem and the membership problem are decidable for finitely presented subgroups of direct products of 2-dimensional coherent RAAGs. This work generalizes the results of Bridson, Howie, Miller and Short for free groups.
Navigating Global Uncertainty: Examining the Effect of Geopolitical Risks on Cryptocurrency Price and Volatility in Markov-Switching Vector Autoregressive Model
Authors: Buthelezi Eugene Msizi 
Published: February 2024

Abstract
This study addresses a gap in the literature on exploring the impact of geopolitical risk on cryptocurrency markets, particularly focusing on Bitcoin, within different price and volatility regimes. By employing generalized autoregressive conditional heteroskedasticity (GARCH) and Markov-Switching Vector Autoregressive (MS-VAR) models using daily data from 01 January 2015 to 15 January 2024. We found evidence suggesting a strong positive relationship between lagged Bitcoin returns and current returns, indicating persistence or momentum in Bitcoin price movements. Additionally, heightened geopolitical risks are found to be associated with decreased current Bitcoin volatility, particularly in state 1 characterized by lower price levels. Conversely, in state 2, characterized by higher price levels, geopolitical risk shocks induce an initial spike followed by a subsequent decrease in Bitcoin price volatility. Furthermore, shock analysis reveals nuanced reactions of Bitcoin prices and volatility to geopolitical events, with distinct patterns observed in different price regimes. Geopolitical risk is found to explain the variance of Bitcoin price and volatility in lower price level states. Given these results, it is recommended that adopting dynamic investment approaches that adjust to changing geopolitical conditions and market regimes can help investors navigate fluctuations in cryptocurrency markets more effectively.
JEL Classifications: G10, G14, F42
Fairness by design in shared-energy allocation problems
Authors: Fornier Zoe , Leclère Vincent , Pinson Pierre 
Published: February 2024

Abstract
This paper studies how to aggregate prosumers (or large consumers) and their collective decisions in electricity markets, with a focus on fairness. Fairness is essential for prosumers to participate in aggregation schemes. Some prosumers may not be able to access the energy market directly, even though it would be beneficial for them. Therefore, new companies offer to aggregate them and promise to treat them fairly. This leads to a fair resource allocation problem.
We propose to use acceptability constraints to guarantee that each prosumer gains from the aggregation. Moreover, we aim to distribute the costs and benefits fairly, taking into account the multi-period and uncertain nature of the problem. Rather than using financial mechanisms to adjust for fairness issues, we focus on various objectives and constraints, within decision problems, that achieve fairness by design. We start from a simple single-period and deterministic model, and then generalize it to a dynamic and stochastic setting using, e.g., stochastic dominance constraints.
Microservice deployment strategy based on interaction weight in edge environment
Authors: He Shuilang , Xiong Anping , Zhang Ming , Li Changwu 
Published: February 2024

Abstract

This paper proposes a microservice deployment strategy based on interactive weights to optimize the deployment of microservices in edge environments. In an edge computing environment, this strategy is particularly important to reduce data transmission latency and improve processing efficiency as data is processed and stored closer to where the data is generated. The proposed deployment strategy evaluates the dependencies between microservices based on their interaction weights, and models computation and transport latency to minimize the overall latency of applications in the edge network. By introducing an interactive weight factor and constructing an end-to-end delay model of microservices, this strategy can effectively deal with the variability of microservice requests and the diversification of network transmission in edge computing environments. The experimental results show that this strategy is effective in reducing the overall latency of microservice deployment, and can deal with the interactions and dependencies between microservices more effectively than the traditional greedy algorithm (GA), random algorithm (RA) and other interactively aware deployment strategies (such as IntMA). In addition, experimental evaluations on open source microservices applications such as BookInfo validate the effectiveness of the proposed strategy.
NOx emission reduction in low viscous low cetane (LVLC) fuel using additives in CI engine – An experimental study
Authors: Sonthalia Ankit , Varuvel Edwin Geo , Subramanian Thiyagarajan , Kumar Naveen 
Published: February 2024

Abstract

This study examines the combustion properties of pine oil (PO), which is classified as a low viscosity, low cetane (LVLC) fuel. It highlights the superior performance of pine oil in comparison to diesel fuel, but acknowledges that its low cetane index causes a delay in combustion initiation, which consequently results in elevated NOx emissions. Fuel atomization, evaporation, and air/fuel mixing is enhanced by the reduced viscosity and boiling point of PO in comparison to diesel. Nevertheless, the low cetane index of PO restricts its applicability as a diesel fuel substitute in CI engines. Because of the significant heat release that occurs subsequent to an extended ignition delay, NOx emissions tend to rise with less viscous and low cetane (LVLC) fuels. A range of cetane improvers, such as diethyl ether (DEE), benzyl alcohol (Bn), diglyme (DGE), and methyl tert-butyl ether (MTBE), have demonstrated effectiveness in mitigating nitrogen oxide (NOx) emissions upon introduction into pine oil. All the cetane improvers were added 5 % and 10 % by volume with pine oil.
A twin-cylinder tractor engine operating at a constant speed of 1500 revolutions per minute was utilized in this testing. In order to achieve a warm-up condition that would enable the smooth operation of PO, the engine was initially operated on diesel fuel. At maximum load condition, NOx emission of PO was higher by 8% in comparison to diesel. NOx emission was significantly reduced with addition of cetane improvers. Maximum reduction of 7% was observed with PO + MTBE 10% in comparison to PO which is in par with diesel. An increase in HC and CO emission was observed with all cetane improver addition with PO.
Evaluate the effectiveness of three methods of measurement catheter fixation during urodynamic study: a single-center small sample size study
Authors: Zeng Xiao , Huang Zhihui , Zhang Jie , Shen Hong , Luo De-yi , Jin Tao 
Published: February 2024

Abstract

Objectives
This study in order to provide better evidence for the selection of fixation methods for measurement catheters during clinical UDS .
Methods
We selected patients who had undergone urodynamic examinations at the XXX between April and June 2023. These patients were chosen based on the inclusion and exclusion criteria established for the study. We observed the effectiveness of three different fixation methods: 1.Waterproof Tape Fixation(group1) 2. Patient-Manual Fixation(group2) 3. Silk Thread Fixation(group3).
Results
There were 28 patients enrolled in each group, and the mean ages were: 62.82 ± 15.59, 66.14 ± 8.63, 63 ± 16.78 years, respectively. MCC, BC, Qmax, Pdet.Qmax, BCI and BOO in 3 different catheter fixation methods had no statistical difference (P > 0.05). The total incidence of catheter displacement in group1, group2 and group3 was 35.71%, 0, 14.29%, respectively. There was a statistically significant difference between the Comfort-B scale of Group 1 and Group 2, Group 2 and Group 3 (p < 0.000). Regarding the visual analogue scores, there was a statistically significant difference between Group 1 and Group 2, Group 2 and Group 3 (p < 0.000).
Conclusions
We conducted a preliminary verification and found that three different methods of catheter fixation during UDS had no significant impact on the test results. However, it is important to note that patient-manual fixation, as well as the other two fixation methods, may result in decreased comfort and increased pain for patients during the UDS process.
Clinical trial registration: ChiCTR2300068280. 2023-5-15
Birds in the technosphaera
Authors: Шилин М.Б. , Леднова Ю.А. , Меньшакова М.Ю. , Гайнанова Р.И. , Румянцева Е.А. 
Published: February 2024

По результатам анализа опыта наилучшей международной практики рассмотрено воздействие на птиц различных компонентов техносферы: урбоэкосистем; объектов рекреации; портовых комплексов и паромных переправ; объектов нефтедобывающей промышленности; объектов инфраструктуры возобновляющихся источников энергии (полей ветряных мельниц и т. п.). Оценена роль птиц в системе экологического мониторинга объектов техносферы. Постулируется необходимость системного подхода, при котором техносфера рассматривается с позиции эмерджентности не как простая совокупность различных объектов, а как качественно новое единство взаимодействующих компонентов. Выявлены факторы положительного и негативного воздействия техногенных объектов на орнитофауны. Показано, что проанализированные виды воздействия антропогенных объектов на орнитофауну должны рассматриваться в совокупности, на основе системного подхода.
On the base of analysis of the best international practice, the influence of different technosphaeric components on birds is evaluated – such as urboecosystems, objects of recreation, marine port complexes and ferry, objects of oiland gas sector, objects of the infrastructure of renewable energy sources (wind mills etc.). The role of the birds in the system of monitoring of the technosphaere is evaluated. The necessity of the system approach is postulated, when the technosphaera is observed from the position of emergence, not like the simple totality of different objects, but principally new unity of the interactional components. Factors of positive and negative effects of the technosphaeric objects on the ornithofauna are revealed. It is shown that the anthropogenic effects on ornithofauna should be estimated as a complex, on the base of the system approach.
COM CERTO AR - Intervenções na Preexistência
Authors: Villarim Lizia , Gago João , Guimarães Pryscila , De Queiroz Mariá 
Published: February 2024

O projeto "Com Certo Ar" resulta da participação no concurso de reabilitação de edificações em João Pessoa, Paraíba, Brasil, promovido pelo IVADS 2023 em colaboração com instituições como UFRN, UFPE, UFPB e Universidade de Lisboa. O desafio lançado visava reabilitar edifícios actualmente abandonados em centros de atividades relacionadas com a economia criativa. Este projeto procurou criar um ambiente estimulante, promover a rotatividade de usuários e incluir a população local, evitando, desta forma, a gentrificação.
O destaque da proposta relaciona-se com a integração da praça adjacente como elemento central, indo além do que era solicitado. Estabeleceram-se conexões entre as ruas, a praça e a estação de caminhos-de-ferro, inspirados na abordagem de Álvaro Siza para o Chiado, em Lisboa. Isso não só possibilitou a criação espaços para a economia criativa, como também poderia contribuir eficazmente para a promoção da segurança urbana através da ocupação efetiva do espaço público.
Ao cumprir o programa exigido a equipe foi galardoada com uma Menção Honrosa, o que permite verificar que o projeto proposto demonstrou uma resposta informada às necessidades, destacando-se pela sua multifuncionalidade, e, atraindo a comunidade para o centro histórico. Essa abordagem não apenas reabilita fisicamente os espaços edificados, mas também revitaliza o tecido social e econômico da área, contribuindo para um ambiente urbano mais dinâmico e seguro.
Heterocyclic-Based Analogues against Sarcine-Ricin Loop RNA from
Escherichia coli: In Silico Molecular Docking Study and Machine Learning
Classifiers
Authors: Sharma Shivangi , Choubey Rahul , Gupta Manish , Singh Shivendra 
Published: February 2024

Background:
Heterocyclic-based drugs have strong bioactivities, are active pharmacophores,
and are used to design several antibacterial drugs. Due to the diverse biodynamic properties
of well-known heterocyclic cores, such as quinoline, indole, and its derivatives, they have a special
place in the chemistry of nitrogen-containing heterocyclic molecules.

Objective:
The objective of this study is to analyze the interaction of several heterocyclic molecules
using molecular docking and machine learning approaches to find out the possible antibacterial
drugs.

Methods:
The molecular docking analysis of heterocyclic-based analogues against the sarcin-Ricin
Loop RNA from E. coli with a C2667-2'-OCF3 modification (PDB ID: 6ZYB) is discussed.

Results:
Many heterocyclic-based derivatives show several residual interaction, affinity, and hydrogen
bonding with sarcin-Ricin Loop RNA from E. coli with a C2667-2'-OCF3 alteration which
are identified by the investigation of in silico molecular docking analysis of such heterocyclic derivatives.

Conclusion:
The dataset from the molecular docking study was used for additional optimum analysis,
and the molecular descriptors were classified using a variety of machine learning classifiers,
including the GB Classifier, CB Classifier, RF Classifier, SV Classifier, KNN Classifier, and Voting
Classifier. The research presented here showed that heterocyclic derivatives may operate as
potent antibacterial agents when combined with other compounds to produce highly efficient antibacterial
agents.