bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broad-spectrum antibiotic prophylaxis in tumor and infected orthopedic surgery—the prospective-randomized, microbiologist-blinded, stratified, superiority trials: BAPTIST Trials
Authors: Uçkay Ilker , Bomberg Hagen , Risch Markus , Müller Daniel , Betz Michael , Farshad Mazda 
Published: January 2024

Abstract
Background
The perioperative antibiotic prophylaxis with 1st or 2nd generation cephalosporins is evidence-based in orthopedic surgery. There are, however, situations with a high risk of prophylaxis-resistant surgical site infections (SSI).

Methods
We perform a superiority randomized controlled trial with a 10% margin and a power of 90% in favor of the broad-spectrum prophylaxis. We will randomize orthopedic interventions with a high risk for SSI due to selection of resistant pathogens (open fractures, surgery under therapeutic antibiotics, orthopedic tumor surgery, spine surgery with American Society of Anesthesiologists (ASA) score ≥ 3 points) in a prospective-alternating scheme (1:1, standard prophylaxis with cefuroxime versus a broad-spectrum prophylaxis of a combined single-shot of vancomycin 1 g and gentamicin 5 mg/kg parenterally). The primary outcome is “remission” at 6 weeks for most orthopedic surgeries or at 1 year for surgeries with implant. Secondary outcomes are the risk for prophylaxis-resistant SSI pathogens, revision surgery for any reason, change of antibiotic therapy during the treatment of infection, adverse events, and the postoperative healthcare-associated infections other than SSI within 6 weeks (e.g., urine infections or pneumonia). With event-free surgeries to 95% in the broad-spectrum versus 85% in the standard prophylaxis arm, we need 2 × 207 orthopedic surgeries.

Discussion
In selected patients with a high risk for infections due to selection of prophylaxis-resistant SSI, a broad-spectrum combination with vancomycin and gentamycin might prevent SSIs (and other postoperative infections) better than the prophylaxis with cefuroxime.

Trial registration
ClinicalTrial.gov NCT05502380. Registered on 12 August 2022. Protocol version: 2 (3 June 2022)
Optimizing the use of ketamine to reduce chronic postsurgical pain in women undergoing mastectomy for oncologic indication: study protocol for the KALPAS multicenter randomized controlled trial
Authors: Wang Jing , Doan Lisa V. , Axelrod Deborah , Rotrosen John , Wang Binhuan , Park Hyung G. , Edwards Robert R. , Curatolo Michele , Jackman Carina , Perez Raven ,   NCATS Trial Innovation Network
Published: January 2024

Abstract
Background
Mastectomies are commonly performed and strongly associated with chronic postsurgical pain (CPSP), more specifically termed postmastectomy pain syndrome (PMPS), with 25–60% of patients reporting pain 3 months after surgery. PMPS interferes with function, recovery, and compliance with adjuvant therapy. Importantly, it is associated with chronic opioid use, as a recent study showed that 1 in 10 patients continue to use opioids at least 3 months after curative surgery. The majority of PMPS patients are women, and, over the past 10 years, women have outpaced men in the rate of growth in opioid dependence. Standard perioperative multimodal analgesia is only modestly effective in prevention of CPSP. Thus, interventions to reduce CPSP and PMPS are urgently needed. Ketamine is well known to improve pain and reduce opioid use in the acute postoperative period. Additionally, ketamine has been shown to control mood in studies of anxiety and depression. By targeting acute pain and improving mood in the perioperative period, ketamine may be able to prevent the development of CPSP.

Methods
Ketamine analgesia for long-lasting pain relief after surgery (KALPAS) is a phase 3, multicenter, randomized, placebo-controlled, double-blind trial to study the effectiveness of ketamine in reducing PMPS. The study compares continuous perioperative ketamine infusion vs single-dose ketamine in the postanesthesia care unit vs placebo for reducing PMPS. Participants are followed for 1 year after surgery. The primary outcome is pain at the surgical site at 3 months after the index surgery as assessed with the Brief Pain Inventory-short form pain severity subscale.

Discussion
This project is part of the NIH Helping to End Addiction Long-term (HEAL) Initiative, a nationwide effort to address the opioid public health crisis. This study can substantially impact perioperative pain management and can contribute significantly to combatting the opioid epidemic.

Trial registration
ClinicalTrials.gov NCT05037123. Registered on September 8, 2021.
Effects of caffeine supplementation on anaerobic power and muscle activity in youth athletes
Authors: Ghazaleh Leila , Enayati Anita , Delfan Maryam , Bamdad Sobhan , Laher Ismail , Granacher Urs , Zouhal Hassane 
Published: January 2024

AbstractThis study aimed to investigate the effects of caffeine ingestion on anaerobic performance and muscle activity in young athletes. In this randomized, double-blind, and placebo-controlled study, ten highly trained male post-puberal futsal players aged 15.9 ± 1.2 years conducted two laboratory sessions. Athletes performed the Wingate test 60 min after ingestion of caffeine (CAF, 6 mg/kg body mass) or placebo (PL, dextrose) (blinded administration). Peak power, mean power, and the fatigue index were assessed. During the performance of the Wingate test, electromyographic (EMG) data were recorded from selected lower limbs muscles to determine the root mean square (RMS), mean power frequency (MPF), and median power frequency (MDPF) as frequency domain parameters and wavelet (WT) as time-frequency domain parameters. Caffeine ingestion increased peak (0.80 ± 0.29 W/Kg; p = 0.01; d = 0.42) and mean power (0.39 ± 0.02 W/Kg; p = 0.01; d = 0.26) but did not significantly affect the fatigue index (52.51 ± 9.48%, PL: 49.27 ± 10.39%; p = 0.34). EMG data showed that the MPF and MDPF parameters decreased and the WT increased, but caffeine did not have a significant effect on these changes (p > 0.05). Moreover, caffeine ingestion did not significantly affect RMS changes in the selected muscles (p > 0.05). Here we showed that acute caffeine ingestion improved anaerobic performance without affecting EMG parameters in young male futsal athletes.
A young woman with acute coronary syndrome and antiphospholipid syndrome. Is it the antiphospholipid syndrome or COVID-19 vaccination or classical risk as the risk factor? a case report
Authors: Siagian Sisca Natalia , Christianto Christianto 
Published: January 2024

Abstract
Background
Acute coronary syndrome (ACS) in young women is poorly understood due to underdiagnosis and undertreatment. One of the possible risk factors for ACS in young women is antiphospholipid syndrome (APS). Coronavirus disease 2019 (COVID-19) vaccination also emerged as one of the possible risk factors for ACS during the COVID-19 pandemic.

Case presentation
Our patient, a 39-year-old Batak woman with dyslipidemia and family history of cardiovascular disease, experienced chest pain slightly improved at rest accompanied by autonomic symptoms. She was diagnosed with non-ST-elevation myocardial infarction (NSTEMI) based on her clinical features, dynamic electrocardiogram changes, troponin elevation, and multislice computed tomography angiography confirmed with diagnostic catheterization. The patient was managed by percutaneous coronary intervention with implantation of drug-eluting stents. On follow-up, the patient was diagnosed with APS based on history of preeclampsia with severe features in the first and third pregnancy, spontaneous abortion in the second pregnancy, history of transient ischemic attack, moderately positive lupus anticoagulant on two occasions with an interval of 12 weeks, and ACS. Further investigation revealed a history of COVID-19 vaccination with Sinovac four and six weeks before presentation. The patient was recommended for lifelong warfarin and short-term dual antiplatelet (aspirin and ticagrelor).

Conclusions
Young women are not completely immune to ACS as evident in this case of ACS in a young woman with classical risk factors (dyslipidemia and family history of cardiovascular disease) and APS. Further studies are required to fill the knowledge gap on whether COVID-19 vaccination had any contribution to the ACS in the young woman.
Inertial Halpern-type iterative algorithm for the generalized multiple-set split feasibility problem in Banach spaces
Authors: Eslamian Mohammad 
Published: January 2024

AbstractIn this paper, we study the generalized multiple-set split feasibility problem including the common fixed-point problem for a finite family of generalized demimetric mappings and the monotone inclusion problem in 2-uniformly convex and uniformly smooth Banach spaces. We propose an inertial Halpern-type iterative algorithm for obtaining a solution of the problem and derive a strong convergence theorem for the algorithm. Then, we apply our convergence results to the convex minimization problem, the variational inequality problem, the multiple-set split feasibility problem and the split common null-point problem in Banach spaces.
Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae among healthy children under 5 years of age in Hainan Province, China
Authors: Wang Jian , Qiu Li , Bai Shuang , Zhao Wei , Zhang Ao , Li Jing , Zhang Jun-Nan , Zhou Shan-Shan , Qiu Ren , Huang Zhu , Liu Jv-Xia , Wang Ting-Bin , Sun Xue , Wu Jiang , Zheng Qun , He Bin , Lv Min 
Published: January 2024

Abstract
Background
The thirteen-valent pneumococcal conjugate vaccine (PCV13) is not included in the national immunization program and is administered voluntarily with informed consent in China. In preparation for assessing the impact of pilot introduction in Hainan Province, we conducted a carriage study among children under 5 years of age from four locations in Hainan Province, China.

Methods
From March to June 2022, nasopharyngeal (NP) swabs, collected from healthy children aged younger than 59 months who lived in the 4 different locations (Haikou, Wanning, Baisha and Qiongzhong) in Hainan Province, were tested for pneumococcus using conventional culture. Pneumococcal isolates were serotyped using the Quellung reaction. Risk factors associated with pneumococcal colonization were assessed using univariate analysis and multivariable logistic regression adjusting for age, daycare attendance and other factors.

Results
Pneumococcus was isolated in 710 (30.4%) of the 2333 children enrolled. Of 737 pneumococci, 29 serotypes were identified; 60.9% were PCV13 serotypes; the most common vaccine serotypes were 6B (20.4%), 19F (13.0%), 6A (11.9%) and 23F (6.1%); and the most common nonvaccine serotypes were 23A (12.9%), 34 (6.1%) and nontypeable (NT) pneumococci (5.6%). Children vaccinated with PCV13 had lower carriage (17.7% vs 32.5%; P = 0.0001) and fewer PCV13 serotypes (41.9% vs 62.7%; P = 0.0017) compared to unimmunized children. After adjustment, NP carriage was higher among children attending daycare (aOR = 2.3, 95% CI: 1.7–3.2), living in rural areas (aOR = 1.4, 95% CI: 1.1–1.8), living with siblings (aOR = 1.3, 95% CI: 1.0–1.6) and whose mothers had completed senior high/technical secondary school (aOR = 1.5, 95% CI: 1.1–2.0). In contrast, completion of 3–4 doses of PCV13 were associated with a lower carriage rate (aOR = 0.6, 95% CI: 0.4–0.9).

Conclusions
We established the baseline of pneumococcal carriage, serotype distribution and PCV13 immunization rates among healthy children under 5 years of age in Hainan Province, prior to the introduction of PCV13 into the national immunization program. The high proportion of PCV13 serotypes suggests that PCV13 introduction will likely have a substantial impact on pneumococcal carriage in Hainan Province.

Graphical Abstract
Loneliness, immunological recovery patterns, and health-related quality of life (HRQOL) outcomes in patients receiving hematopoietic stem cell transplantation
Authors: Lange Lori J. , Ames Steven C. , Ames Gretchen E. , Heckman Michael G. , White Launia J. , Roy Vivek , Foran James M. 
Published: January 2024

Abstract
Purpose
Loneliness may compromise health-related quality of life (HRQOL) outcomes and the immunological impacts of loneliness via neuroendocrinological mechanisms likely have consequences for patients who have undergone a hematopoietic stem cell transplantation (HSCT).

Research approach and measures
Loneliness (pre-transplant), immunological recovery (Day 30, Day 100, 1-year post-transplant), and HRQOL (Day 100, 1 year) were measured in a sample of 205 patients completing a HSCT (127 autologous, 78 allogenic).

Results
Greater levels of pre-transplant loneliness predicted poorer HRQOL at Day 100 and 1-year follow-up. Loneliness also was associated with higher absolute neutrophil to absolute lymphocyte (ANC/ALC) ratios in the entire sample at Day 30, which in turn was associated with Day 100 HRQOL.

Conclusions
Findings demonstrate that pretransplant loneliness predicts HRQOL outcomes and associates with inflammatory immunological recovery patterns in HSCT patients. The balance of innate neutrophils to adaptive lymphocytes at Day 30 present a distinct profile in lonely individuals, with this immunity recovery profile predicting reduced HRQOL 100 days after the transplant. Addressing perceptions of loneliness before HSCT may be an important factor in improving immunological recovery and HRQOL outcomes.
CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions
Authors: Tauziède-Espariat Arnault , Lew-Derivry Lucille , Abbou Samuel , Métais Alice , Pierron Gaëlle , Reynaud Stéphanie , Masliah-Planchon Julien , Mariet Cassandra , Hasty Lauren , Dangouloff-Ros Volodia , Boddaert Nathalie , Csanyi Marie , Aline-Fardin Aude , Lamaison Claire , Chrétien Fabrice , Beccaria Kévin , Puget Stéphanie , Varlet Pascale 
Published: January 2024

AbstractErythroblastic sarcoma (ES) (previously called chloroma or granulocytic sarcoma) are rare hematological neoplams characterized by the proliferation of myeloid blasts at extramedullary sites, and primarily involve the skin and soft tissue of middle-aged adults. ES may be concomitant with or secondary to myeloid neoplasms (mostly acute myeloid leukemia (AML)) or in isolated cases (de novo) without infiltration of the bone marrow by blasts. ES share cytogenetic and molecular abnormalities with AML, including RUNX1T1 fusions. Some of these alterations seem to be correlated with particular sites of involvement. Herein, we report an isolated erythroblastic sarcoma with NFIA::RUNX1T1 located in the central nervous system (CNS) of a 3-year-old boy. Recently, two pediatric cases of CNS MS with complete molecular characterization have been documented. Like the current case, they concerned infants (2 and 3 years-old) presenting a brain tumor (pineal involvement) with leptomeningeal dissemination. Both cases also harbored a NFIA::RUNX1T3 fusion. ES constitutes a diagnostic challenge for neuropathologists because it does not express differentiation markers such as CD45, and may express CD99 which could be confused with CNS Ewing sarcoma. CD43 is the earliest pan-hematopoietic marker and CD45 is not expressed by erythroid lineage cells. E-cadherin (also a marker of erythroid precursors) and CD117 (expressed on the surface of erythroid lineage cells) constitute other immunhistochemical hallmarks of ES. The prognosis of patients with ES is similar to that of other patients with AML but de novo forms seem to have a poorer prognosis, like the current case. To conclude, pediatric ES with NFIA::RUNX1T1/3 fusions seem to have a tropism for the CNS and thus constitute a potential pitfall for neuropathologists. Due to the absence of circulating blasts and a DNA-methylation signature, the diagnosis must currently be made by highlighting the translocation and expression of erythroid markers.
3D thermal structural and dehydration modeling in the southern Chile subduction zone and its relationship to interplate earthquakes and the volcanic chain
Authors: Iwamoto Kaya , Suenaga Nobuaki , Yoshioka Shoichi , Ortega-Culaciati Francisco 
Published: January 2024

AbstractIn southern Chile, the Nazca plate is subducting beneath the South American plate. This region was struck by megathrust earthquakes in 1960 and 2010 and is characterized by the existence of a volcanic chain. In this region, we modeled a three-dimensional thermal structure associated with the subduction of the Nazca plate by using numerical simulations. Based on the obtained temperature distribution, we determined the updip and downdip limit temperatures for the region ruptured by these two megathrust earthquakes. In addition, the distributions of water content and dehydration gradient were calculated by using appropriate phase diagrams and compared with the location of the volcanic chain. As a result, we infer that the coseismic slip of the 2010 Mw8.8 Maule earthquake occurred only at temperatures lower than and around the 350 °C isotherm that resembles the beginning of the brittle‒ductile transition. We also deduce that the rupture of the 1960 Mw9.5 Valdivia earthquake propagated up to the 450 °C isotherm because the magnitude was considerably large and the young hot plate subducted near the Chile Ridge. In addition, the hydrous minerals in the turbidites, MORB and ultramafic rocks released fluids via dehydration reactions, and dehydrated water migrated upward almost vertically, decreasing the melting point of the mantle wedge and contributing to the formation of the volcanic chain.
Nexus of governance, macroeconomic conditions, and financial stability of banks: a comparison of developed and emerging countries
Authors: Ullah Saif , Ullah Atta , Zaman Mubasher 
Published: January 2024

AbstractThe study aims to explore the impact of governance and macroeconomic conditions on financial stability in developed and emerging countries. The study sample comprised 122 countries from 2013 to 2020, and a comprehensive set of variables was used to construct the financial stability index (FSI). The results of the two-step system GMM analysis, robust with D–K regression, indicate that interest rate, GDP growth, voice and accountability, political stability and absence of violence/terrorism, government effectiveness, regulatory quality, and control of corruption have a positive and statistically significant impact on financial stability. However, inflation, money supply, and the rule of law have adverse and insignificant effects on financial stability. Notably, the findings vary between developed and emerging countries due to differences in governance and macroeconomic conditions and their role in financial stability. The study concludes that regulatory governance and macroeconomic conditions are crucial for financial stability. These outcomes are significant for central banks, academia, and policymakers, as they emphasize the need for stable financial systems and sustainable, balanced growth through governance and macroeconomic conditions.
Librarians and information specialists as methodological peer-reviewers: a case-study of the International Journal of Health Governance
Authors: Ibragimova Irina , Fulbright Helen 
Published: January 2024

Abstract
Background
Objectives of this study were to analyze the impact of including librarians and information specialist as methodological peer-reviewers. We sought to determine if and how librarians’ comments differed from subject peer-reviewers’; whether there were differences in the implementation of their recommendations; how this impacted editorial decision-making; and the perceived utility of librarian peer-review by librarians and authors.

Methods
We used a mixed method approach, conducting a qualitative analysis of reviewer reports, author replies and editors’ decisions of submissions to the International Journal of Health Governance. Our content analysis categorized 16 thematic areas, so that methodological and subject peer-reviewers’ comments, decisions and rejection rates could be compared. Categories were based on the standard areas covered in peer-review (e.g., title, originality, etc.) as well as additional in-depth categories relating to the methodology (e.g., search strategy, reporting guidelines, etc.). We developed and used criteria to judge reviewers’ perspectives and code their comments.
We conducted two online multiple-choice surveys which were qualitatively analyzed: one of methodological peer-reviewers’ perceptions of peer-reviewing, the other of published authors’ views on the suggested revisions.

Results
Methodological peer-reviewers assessed 13 literature reviews submitted between September 2020 and March 2023. 55 reviewer reports were collected: 25 from methodological peer-reviewers, 30 from subject peer-reviewers (mean: 4.2 reviews per manuscript). Methodological peer-reviewers made more comments on methodologies, with authors more likely to implement their changes (52 of 65 changes, vs. 51 of 82 by subject peer-reviewers); they were also more likely to reject submissions (seven vs. four times, respectively). Where there were differences in recommendations to editors, journal editors were more likely to follow methodological peer-reviewers (nine vs. three times, respectively). The survey of published authors (87.5% response rate) revealed four of seven found comments on methodologies helpful. Librarians’ survey responses (66.5% response rate) revealed those who conducted peer-reviews felt they improved quality of publications.

Conclusions
Librarians can enhance evidence synthesis publications by ensuring methodologies have been conducted and reported appropriately. Their recommendations helped authors revise submissions and facilitated editorial decision-making. Further research could determine if sharing reviews with subject peer-reviewers and journal editors could benefit them in better understanding of evidence synthesis methodologies.
Efficacy and safety of different bupivacaine concentrations in periarticular infiltration combined with adductor canal block for bilateral total knee arthroplasty: a randomized controlled trial
Authors: Dej-arkom Sukanya , Pangthipampai Pawinee , Chandranipapongse Weerawadee , Chatsirichareonkul Somruedee , Narkbunnam Rapeepat , Charoencholvanich Keerati , Tangchittam Suwida , Iamaroon Arissara 
Published: January 2024

Abstract
Background
Pain management for bilateral total knee arthroplasty (BTKA) often combines adductor canal block (ACB) with periarticular infiltration (PAI). However, concerns arise regarding local anesthetic toxicity. This study evaluated the efficacy and safety of different bupivacaine concentrations in simultaneous BTKA.

Methods
Patients undergoing simultaneous BTKA under spinal anesthesia were included in the study. They received ACB with 50 mg bupivacaine for each thigh. The patients were then randomized into two groups. Group A was administered a PAI of 100 mg bupivacaine per knee (totaling 300 mg bupivacaine for ACB and PAI). Group B received a PAI with 50 mg bupivacaine per knee (totaling 200 mg bupivacaine for ACB and PAI). Postoperative pain was assessed using a visual analog scale at 4-h intervals for 48 h after surgery. Plasma bupivacaine concentrations were measured at eight specified times. Postsurgery walking ability was also evaluated.

Results
Among the 57 participants analyzed, visual analog scale pain scores revealed no significant differences between the two groups. An interim analysis of plasma bupivacaine concentrations in both groups indicated no significant disparities. In group B, 93.1% managed to walk with assistance within 48 h, as opposed to group A’s 71.4% (P = 0.041).

Conclusions
Combining ACB with 100 mg bupivacaine and PAI with another 100 mg bupivacaine provided effective pain relief. This combination also had a better safety profile and led to more patients walking postsurgery than when combining ACB with 100 mg bupivacaine and PAI with 200 mg bupivacaine. Thus, ACB combined with PAI with a total dose of 200 mg bupivacaine appears suitable for simultaneous BTKA.
Trial registration: ClinicalTrials.gov (NCT03249662).