bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Volar Distal Radial Ulnar Joint Dislocation
Authors: Acosta Jonathan , Smith Kira , McKinney Richard , Hammarstedt Jon , Regal Steven 
Published: November 2023

Case:
We report the case of a 34-year-old woman with a chronic right volar dislocation of the distal radioulnar joint (DRUJ) and associated ulnar styloid fracture. The patient presented 1 month after a dog bite injury with wrist pain and limited range of motion, and radiographs demonstrated volar DRUJ dislocation. Closed reduction was unsuccessful, and thus, open reduction was performed.

Conclusion:
Isolated volar DRUJ dislocations in the absence of fractures are easy to misdiagnose on plain radiographs. We present our surgical technique and fixation algorithm for open reduction and stabilization for chronic volar DRUJ dislocations.
Investigation of the Effects of Sea, Drinking, Mineral and Fountain Water on Microstrip Patch Antenna
Authors: Duman Mehmet 
Published: November 2023

Abstract
Antennas are exposed to various environmental conditions while transmitting or receiving signals in the form of electromagnetic waves. Although they are intended to work outdoors or in areas that will not cause signal attenuation, they cannot always find such an environment. Water puddles in front of the antenna’s radiation pattern due to rain or other reasons cause wave attenuation.
Vibration-enabled mobility of liquid metal
Authors: Handschuh-Wang Stephan , Gan Tiansheng , Wang Tao , He Bin , Han Peigang , Stadler Florian , Zhou Xuechang 
Published: November 2023

Abstract

Directed liquid metal (gallium-based) manipulation and actuation are paramount for copious applications, including soft robotics, soft electronics, and targeted drug delivery. Although there are several strategies available to achieve mobility of liquid metals in a “wet” environment. Strategies to achieve and improve mobility of liquid metal droplets and puddles in a “dry” environment have been scarce and rely on metallophobic surface design or liquid metal marbles. Here, we elucidate high mobility of Galinstan by combining metallophobic surface design and vertical vibrations. Vibration frequencies between 20 and 30 Hz were conducive to droplet movement and threshold inclination angles of 0.5 to 1° were observed upon actuation by these vibrations. The method itself is applicable for a wide range of droplet sizes (30 and 2000 µL) and very robust. The droplet movement typically comprises of periodic receding and advancing of the droplet and commences via a rolling mechanism rather than a gliding mechanism. Finally, we show that small (0.5 mm height) obstacles can be traversed by this method, indicating that it can be used in concert with other strategies, such as surface structuring strategies, which open up pathways for mobility and controlled actuation of liquid metal droplets in air.
Increased Epicardial Adipose Tissue Thickness As a Sign of Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis and Its Relationship with Disease Activity Indices
Authors: Dincer Ayse Bahar Kelesoglu , Şahan Haluk Furkan 
Published: November 2023

Abstract

Objective
Epicardial adipose tissue is a novel cardiometabolic risk factor and indicator of subclinical atherosclerosis. We aimed to evaluate the epicardial adipose tissue thickness in rheumatoid arthritis patients and its association with disease activity scores.
Methods
A total of 81 rheumatoid arthritis (RA) patients and 70 age- and sex-matched healthy individuals were recruited for this cross-sectional study. Epicardial adipose tissue thickness (EATT) was measured by transthoracic two-dimensional echocardiography. Tender and swollen joint counts were recorded at the time of inclusion. The laboratory tests included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor, anti-citrullinated protein antibodies, and serum lipid levels. Disease activity was calculated based on Disease Activity Scores for 28 joints (DAS-28) ESR and CRP, the Simple Disease Activity Index (SDAI), and the Clinical Disease Activity Index (CDAI).
Results
Epicardial adipose tissue thickness was significantly higher in the RA patients compared to the healthy controls (p < 0.001). We found statistically significant correlations of EATT with all disease activity indices (p < 0.001) and CRP (p = 0.002). According to a cut-off value of 6.4 mm determined for epicardial adipose tissue thickness, the RA patients with thickness ≥ 6.4 mm had higher disease activity scores and CRP levels. In the multivariable regression analysis, only SDAI score was found as an independent risk factor for increased EATT (OR, (95%CI), 13.70 (3.88–48.43), p < 0.001).
Conclusions
Epicardial adipose tissue thickness measurement by echocardiography is a reliable method for assessing subclinical atherosclerosis in rheumatoid arthritis patients, and a higher disease activity score is an independent risk factor for coronary artery disease.
Climate speeds help frame relative ecological risk in future climate change and stratospheric aerosol injection scenarios
Authors: Hueholt Daniel , Barnes Elizabeth , Hurrell James , Morrison Ariel 
Published: November 2023

Abstract
Stratospheric aerosol injection (SAI) is a potential method of climate intervention to reduce climate risk as decarbonization efforts continue. Two recent Earth system modeling experiments depict policy-relevant SAI scenarios with similar temperature targets (near 1.5°C), but with deployment delayed by 10 years between experiments. This relatively short delay leads to highly distinct profiles of ecological risk from climate speeds. Climate speeds when global temperature is maintained with SAI are indistinguishable on a planetary scale from those experienced under preindustrial conditions. In contrast, the delayed SAI deployment produces very large climate speeds far beyond natural variability and robustly greater in magnitude over land than no-SAI climate change with present policy. Examining the global area exposed to threshold climate speeds facilitates evaluation of relative ecological risk among future climate scenarios. Our results support discussion of tradeoffs and timescales in future climate intervention scenario design and decision-making.
The Contradictive Findings between Ultrasound, Hysteroscopy and Cytokines in Women with Non-hormonal IUD'S Suffering from Metrorrhagia: A Prospective Study
Authors: Watad Hadel , Ifrach Udi , Stockheim David , Yulzari Vered , Meron Orly C. , Blank Miri , Sre Benjamin , Weisz Boaz , Cohen Shlomo B. 
Published: November 2023

Abstract
Purpose: The objective of this study is to assess the correlation between bleeding irregularities and the accurate placement of the IUD device in the uterine cavity, determined through transvaginal ultrasonography and hysteroscopy. Additionally, the study aims to examine the cytokine profile in the uterine cavity and serum of patients experiencing bleeding irregularities after the insertion of non-hormonal IUDs.
Methods: A prospective cohort study was conducted at a single Tertiary medical center, wherein patients experiencing intermenstrual bleeding and spotting after the insertion of non-hormonal IUDs were enrolled. The study involved hysteroscopic and sonographic assessments of the uterine cavity and IUD placement, along with the analysis of blood and uterine cavity cytokine profiles.
Results: During the period between July 2019 and February 2020, a total of eight patients who experienced intermenstrual bleeding and spotting after the insertion of non-hormonal IUDs were enrolled in the study. One case was excluded since a progestative device was detected by ultrasound.
Out of the five cases that underwent a thorough ultrasonographic assessment, 3 cases (60%) showed an embedded IUD. However, these findings were excluded by the hysteroscopic evaluation.
Conclusion: The results suggest that ultrasonographic assessment may lead to an overdiagnosis of IUD mispositioning compared to hysteroscopy. Additionally, both ultrasound and hysteroscopy have limitations in diagnosing the cause of bleeding in most cases. The role of local reactive inflammatory cytokines should be further studied.
The Metaphysics Matrix Questionnaire: the development of an accessible measure of belief change for the general population
Authors: Rennie J. P. , Sjöstedt-Hughes P. , Morgan C. J. A. 
Published: November 2023

Abstract

Anecdotal and empirical evidence suggests that people may undergo substantial shifts in their Metaphysical beliefs (MPBs) following non-ordinary states of consciousness induced by experiences such as meditation, breathwork, near-death, and psychedelics. Despite this, existing measures for assessing MPBs are limited in scope and interpretability, prompting the current study’s objective: to develop a comprehensive and user-friendly questionnaire capable of capturing a diverse range of belief constellations, whilst remaining theoretically informed. Towards this aim, the curation of belief statements for the Metaphysics Matrix Questionnaire (MMQ) used both theory-driven and data-driven methods. 68 Existing items were selected from the literature and combined with 43 newly created items aimed at covering under-addressed metaphysical positions. A factor analysis revealed an eight-factor solution, grouping beliefs into the following broad stroke categories: 1) Religiosity/Spirituality; 2) Physicalism; 3) Transcendency; 4) Panpsychism/Cosmopsychism; 5) Determinism/Fatalism/Low-autonomy; 6) Pseudo-Emergentism; 7) High-autonomy/Moral; 8) Randomness. Following item reduction, 73 items across these factors serve as the basis for the proposed Questionnaire. The MMQ’s potential applications offer valuable insights into beliefs and their impact on mental health outcomes. We provide a discussion on the merits of theory-driven vs data-driven approaches, limitations of the current study, and provide suggestions for future research toward validating the MMQ going forward.
Multi-omics data analysis of COVID-19 patients from Italy, China, Spain and France reveals new biomarkers for early diagnosis and prognosis of SARS-CoV-2 infection
Authors: Cobre Alexandre de Fátima , Alves Alexessander Couto , Gotine Ana Raquel Manuel , Domingues Karime Zeraik Abdalla , Lazo Raul Edison Luna , Ferreira Luana Mota , Tonin Fernanda Stumpf , Pontarolo Roberto 
Published: November 2023

Abstract
Introduction: Apply machine learning models to identify new biomarkers associated with the early diagnosis and prognosis of SARS-CoV-2 infection, aiming to prevent long COVID.
Material and methods: Plasma and serum samples from COVID-19 patients (mild, moderate, and severe), patients with other pneumonias (but with negative COVID-19 RT-PCR) and from healthy volunteers (control), from hospitals in four different countries (China, Spain, France, and Italy) were analyzed by GC-MS, LC -MS and NMR. Machine learning models (PCA and PLS-DA) were developed for predicting the diagnosis and prognosis of COVID-19 and identifying biomarkers associated with these outcomes.
Results. A total of 1410 patient samples were analyzed. In all analyzed data, the PLS-DA model presented a diagnostic and prognostic accuracy of around 95%. A total of 23 biomarkers (e.g. spermidine, taurine, L-aspartic, L-glutamic, L-phenylalanine and xanthine, ornithine and ribothimidine) have been identified as being associated with the diagnosis and prognosis of COVID-19. Additionally, we also identified for the first time six new biomarkers (N-Acetyl-4-O-acetylneuraminic acid, N-Acetyl-L-Alanine, N-Acetyltriptophan, palmitoylcarnitine and glycerol 1-myristate) that are also associated with the severity and diagnosis of COVID-19. These six new biomarkers were elevated in severe COVID-19 patients when compared to patients with mild disease or healthy volunteers.
Conclusion: The PLS-DA model was able to miss the diagnosis and prognosis of COVID-19 around 95%. We also identified six new biomarkers that were increased in plasma and serum of COVID-19 patients (N-Acetyl-4-O-acetylneuraminic acid, N-Acetyl-L-Alanine, N-Acetyltriptophan, palmitoylcarnitine and glycerol 1-myristate) and should be deeply evaluated as prognostic and diagnostic indicators of COVID-19.
Canagliflozin produces a vasorelaxation effect on isolated rat thoracic aorta via NO/cGMP pathways
Authors: Tariq Muhammad Salman , Anjum Irfan , Mushtaq Muhammad Naveed , Barkat Kashif , Badshah Syed Faisal , Ashraf Muhammad Umer , Malik Muhammad Nasir Hayat , Jardan Yousef A. Bin , Nafidi Hiba-Allah , Bourhia Mohammed 
Published: November 2023

Abstract
Canagliflozin is a sodium-glucose cotransporter 2 inhibitor (SGLT2i) an oral hypoglycemic agent. The present study was performed to determine the vasorelaxant response of canagliflozin along with the underlying mechanism. In diabetes-associated complications, those involving blood vessels remain a high cause of morbidity. The diabetes-related cardiovascular complications should be treated with newer drugs that could cure both complications concurrently. The study was conducted on the aortic rings of Wistar rats of either sex. Canagliflozin (10-8-10-4 M) induces relaxation in phenylephrine (PE 100 µM) and 80 mM KCl pre-contracted rings significantly in a cumulative manner acquiring endothelium. The canagliflozin mechanism of vasorelaxant was established by incubating endothelium intact aortic rings for 30 minutes before PE with; nitro-L-arginine methyl ester (L-NAME 100 µM), methylene blue (10 µM), barium chloride (BaCl2: 10 µM), glibenclamide (1 µM) and indomethacin (10 µM). To estimate the role of calcium (Ca+ 2), cumulative Ca2+ (0.01- 10.0 mM) was added in a bath containing Ca+ 2 free Krebs-Henseleit solution. It was repeated by pre-incubating strips with nifedipine (1 µM) and canagliflozin (1 µM, 10 µM and 100 µM) respectively. The relaxant response of canagliflozin involves the release of nitric oxide, cyclic guanosine monophosphate, prostacyclin, and membrane hyperpolarization from endothelium as pretreatment with L-NAME (IC50: 2.166 × 10− 7 ± 7 M ), methylene blue (IC50 : 1.738 × 10− 7 ± 7 M), indomethacin (IC50: 2.269 × 10− 7± 7 M), BaCl2 (IC50 : 3.320 × 10− 6 ± 7 M) and glibenclamide (IC50: 3.960 × 10− 7 ± 7 M) diminished the response. Additionally, canagliflozin relaxing effects include both decreased Ca+ 2 influx and release from sarcoplasmic reserves. Thus, canagliflozin is a possible adjuvant in diabetes with concurrent hypertension.
Effects of ivermectin on development of Calliphora vicina, Robineau-Desvoidy 1830 (Diptera, Calliphoridae)
Authors: Iglesias Lucía E. , Junco Milagros , Sallovitz Juan M. , Lifschitz Adrián L. , Saumell Carlos A. 
Published: November 2023

Abstract

Ivermectin is one of the most widely used drugs for parasite control. Previous studies have shown a reduction in the abundance and diversity of "non-target" coprophilous organisms due to the presence of ivermectin (IVM) in bovine faeces (FM). Due to its breadth of behavioural habits, Calliphora vicina is a suitable dipteran species to evaluate the effects of IVM in FM. The aim of this work was to evaluate the effect of five concentrations of IVM in FM (3,000, 300, 100, 30 and 3 ng/g) on the development of C. vicina, having as endpoints: survival, larval, pupal and adult emergence times (% sex) and LC50. Sampling was performed from larval hatching at 60 and 120 min and at 3, 4, 5, 12 hours and every 24 h specimens were weighed until pupae were observed. Data were analysed by ANOVA using a non-parametric Kruskal-Wallis test and as a function of elapsed development time and accumulated degree hours (ADH). Mortality at 3,000 and 300 ng/g was 100% and 97% respectively. There were delays in the development times that were statistically significant in the adult pupation time (p = 0.0216) and in the ADH (p = 0.0431) between the control group (C) and 100 ng/g. The LC50 was determined at 5.6 ng/g. These results demonstrate the lethal and sub-lethal effects of IVM on C. vicina, while highlighting the usefulness of this species as a bio indicator for ecotoxicological studies.
Faster steroid-free remission with Tocilizumab compared to Methotrexate in Giant Cell Arteritis: a real-life experience in two reference centres.
Authors: Quartuccio Luca , Treppo Elena , De Martino Maria , Pillon Maria , Perniola Simone , Bruno Dario , Isola Miriam , Gremese Elisa 
Published: November 2023

Abstract

Background
Glucocorticoids (GCs) are still the mainstay of treatment of Giant Cell Arteritis (GCA). Although GCs are highly effective in GCA, it is well documented the high burden of toxicity of GCs as well as the disease relapse during GC tapering.
Objectives
To compare the efficacy and rapidity of TCZ and MTX as steroid-sparing agents in a real-life cohort of GCA patients.
Methods
A retrospective analysis was conducted including patients with newly diagnosed GCA from the Rheumatology Units of Udine and Rome. The inclusion criterion was the treatment with TCZ or MTX as first steroid-sparing drug.
Results
112 GCA patients (81 female) with a median age of 70 (IQ 65–75) years were collected. Thirty-one out of 112 (27.7%) patients were treated with TCZ (162mg/week), while 81/112 (72.3%) patients received MTX (up to 20mg/week) as a GC-sparing agent. At month 6 after GCA onset, 5/31 (16.1%) patients in TCZ group and none in MTX group were in GC-free sustained remission (p-value = 0.001). Similarly, at month 12, 64.5% (20/31) and 11.1% (9/81) of patients were in sustained GC-free remission in TCZ and MTX group, respectively (p-value < 0.001). At month 24 of follow-up, at least one relapse of the disease occurred in 7/31 (22.6%) in TCZ-treated and 28/81 (34.6%) in MTX-treated patients, respectively (p-value = 0.22).
Conclusion
TCZ allowed a faster discontinuation of steroid therapy than MTX in GCA patients, with no increased relapse risk.
Assessing Digital Literacy and Willingness to Communicate with Providers Using Digital Technology among Underserved Asian American Patients at a Federally Qualified Health Center: A Cross-Sectional Study
Authors: Lee George , Tran Thu-An , Cui Xinyue , Quach Thu 
Published: November 2023

Abstract

Objective
To understand the digital literacy and attitudes towards telehealth of Asian limited-English proficient (LEP) patients at Asian Health Services in Alameda County, California.
Methods
A cross-sectional survey was conducted with 814 patients at a Federally Qualified Health Center in Burmese, Cantonese, English, Khmer, Korean, Mandarin, Tagalog, and Vietnamese between January and July 2022. Using logistic regression models, we identified predictors of digital literacy and willingness to adapt to telehealth visits.
Results
Among participants, 63% could go online, 26% could log in to a website, 68% had smart devices, 60% used text, and 58% used video. Overall acceptance of video communication with a provider was 89%. Reluctance to use telehealth was related to technical issues in 53% of participants. Based on the regression models, we observed key differences in language groups with respect to application (app) use and attitudes toward telehealth.
Conclusions
There is a digital divide in LEP elderly patients, with technology usage varying by language group. Closing the digital divide involves a multifaceted approach, including device and internet access assistance, culturally and linguistically competent education, and a patient-centric approach to engagement.
Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines
Authors: Soto-Bielicka Patricia , Peropadre Ana , Sanz-Alférez Soledad , Hazen Mª José , Freire Paloma Fernández 
Published: November 2023

Abstract
Research and regulatory efforts in toxicology are increasingly focused on the development of suitable non-animal methodologies for human health risk assessment. In this work we used human intestinal Caco-2 and HCT29/MTX cell lines to address the potential risks of mixtures of the emerging contaminants tetrabromobisphenol A (TBBPA) and commercial polystyrene nanoparticles (PSNPs). We employed different in vitro settings to evaluate basal cytotoxicity through three complementary endpoints (metabolic activity, plasmatic, and lysosomal membrane integrity) and the induction of the oxidative stress and DNA-damage responses with specific endpoints. Although no clear pattern was observed, our findings highlight the predominant impact of TBBPA in the combined exposures under subcytotoxic conditions, and a differential behavior of the Caco-2 and HT29/MTX co-culture system. Distinctive outcomes detected with the mixture treatments include ROS increases, disturbances of mitochondrial inner membrane potential, generation of alkali-sensitive sites in DNA, as well as significant changes in the expression levels of relevant DNA and oxidative stress related genes.
Insights into the critical role of anions in nanofibrillation of cellulose in deep eutectic solvents
Authors: Zhang Qing , Dai Ziliang , Zhang Lili , Wang Zhiguo 
Published: November 2023

Abstract

Complex interactions between cellulose molecules and small molecules can lead to dramatic changes in the structure of the hydrogen bond network in cellulose in green sustainable deep eutectic solvents (DESs). However, the molecular and ionic evolution mechanism of DESs on cellulose nanofibrillation is still unclear. In this study, the mechanism and the critical role of action of ions in DESs on cellulose nanofibrillation were investigated. The results showed that cellulose nanofiber (CNF) with a diameter of less than 200 nm can be prepared directly by DES containing lactic acid (LA) and chloride (LA/ammonium chloride (NH4Cl) and LA/dodecyltrimethylammonium chloride (DTAC) with a diameter of less than 200 nm, and LA/zinc chloride (ZnCl2) with a diameter of less than 100 nm). The Kamlet-Abboud-Taft parameters (KAT value) showed that DESs containing LA have higher hydrogen bond acidity (α) than other systems (such as ethylene glycol and urea) without LA, which can provide more active protons to improve the proton mobility in the cellulose nanofibrillation. And DESs composed of LA and Cl− have high hydrogen bond alkalinity (β), which can lead to great changes in the original hydrogen bond network of cellulose and form a new hydrogen bond structure, thus making the deconstruction of cellulose easy. Thus, LA can be esterified with hydroxyl groups of cellulose under high-temperature moistening conditions, and the CNF prepared by DES system containing LA and Cl− had a highest degree of substitution (DS) (up to 0.73 in LA/ZnCl2 system) after high-temperature moistening.