bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collaborative care model versus usual care for the management of musculoskeletal and co-existing mental health conditions: a randomised feasibility mixed-methods study
Authors: Teixeira Maria Joao Cardoso , Ahmed Refah , Tehrany Rokhsaneh , Jaggi Anju , Ramanuj Parashar 
Published: February 2024

ObjectiveThis study aimed to assess the feasibility of a future trial comparing the collaborative care model with usual care for patients with musculoskeletal conditions and co-existing symptoms of anxiety and depression.DesignA single-centre, parallel-arm, one-to-one, randomised controlled trial design using a mixed-methods approach was used. semistructured interviews and focus groups were conducted post intervention with all participants and staff respectively to explore acceptability towards the model and identify recommendations for improvements.SettingAn orthopaedic rehabilitation outpatient tertiary hospital.ParticipantsAdult patients with musculoskeletal conditions and co-existing moderate or severe symptoms of anxiety and depression attending outpatient therapy appointments.InterventionThe collaborative care model consisted of a tailored management programme to facilitate the integration of care provided by physical and mental healthcare professionals. A case manager screened and coordinated targeted mental health support for participants. Participants allocated to usual care had no support from the case manager.Main outcomes measureFeasibility indicators (rates of recruitment, randomisation and retention), acceptability of clinical outcome measures, usage of additional resources and cost of intervention implementation.ResultsOf the 89 patients who provided consent to take part, 40 participants who matched the eligibility criteria were randomised to either the intervention (n=20) or usual care arm (n=20). Overall adherence to the intervention was 58.82%, while the withdrawal rate was 37.5% at 6 months. All of the 27 participants who were retained completed self-reported outcomes. Qualitative data highlighted that integrated mental health support was favourably perceived. In addition to prenegotiating protected psychology time, the need for operationalised communication between the case manager and clinicians was identified as a recommendation for a future trial.ConclusionsThe trial and intervention were acceptable to patients and healthcare professionals. While the findings demonstrate the feasibility of trial recruitment, a future trial will require optimised retention strategies to improve adherence and withdrawal rates.Trial registration numberNCT05018039.
PRECISION-TBI: a study protocol for a vanguard prospective cohort study to enhance understanding and management of moderate to severe traumatic brain injury in Australia
Authors: Jeffcote Toby , Battistuzzo Camila R , Plummer Mark P , McNamara Robert , Anstey James , Bellapart Judith , Roach Rebecca , Chow Andrew , Westerlund Torgeir , Delaney Anthony , Bihari Shailesh , Bowen David , Weeden Mark , Trapani Anthony , Reade Michael , Jeffree Rosalind L , Fitzgerald Melinda , Gabbe Belinda J , O'Brien Terence J , Nichol Alistair D , Cooper D James , Bellomo Rinaldo , Udy Andrew 
Published: February 2024

IntroductionTraumatic brain injury (TBI) is a heterogeneous condition in terms of pathophysiology and clinical course. Outcomes from moderate to severe TBI (msTBI) remain poor despite concerted research efforts. The heterogeneity of clinical management represents a barrier to progress in this area. PRECISION-TBI is a prospective, observational, cohort study that will establish a clinical research network across major neurotrauma centres in Australia. This network will enable the ongoing collection of injury and clinical management data from patients with msTBI, to quantify variations in processes of care between sites. It will also pilot high-frequency data collection and analysis techniques, novel clinical interventions, and comparative effectiveness methodology.Methods and analysisPRECISION-TBI will initially enrol 300 patients with msTBI with Glasgow Coma Scale (GCS) <13 requiring intensive care unit (ICU) admission for invasive neuromonitoring from 10 Australian neurotrauma centres. Demographic data and process of care data (eg, prehospital, emergency and surgical intervention variables) will be collected. Clinical data will include prehospital and emergency department vital signs, and ICU physiological variables in the form of high frequency neuromonitoring data. ICU treatment data will also be collected for specific aspects of msTBI care. Six-month extended Glasgow Outcome Scores (GOSE) will be collected as the key outcome. Statistical analysis will focus on measures of between and within-site variation. Reports documenting performance on selected key quality indicators will be provided to participating sites.Ethics and disseminationEthics approval has been obtained from The Alfred Human Research Ethics Committee (Alfred Health, Melbourne, Australia). All eligible participants will be included in the study under a waiver of consent (hospital data collection) and opt-out (6 months follow-up). Brochures explaining the rationale of the study will be provided to all participants and/or an appropriate medical treatment decision-maker, who can act on the patient’s behalf if they lack capacity. Study findings will be disseminated by peer-review publications.Trial registration numberNCT05855252.
Youth-centred participatory action approach towards co-created implementation of socially and physically activating environmental interventions in Africa and Europe: the YoPA project study protocol
Authors: Chinapaw Mai J.M. , Klaufus Leonie H. , Oyeyemi Adewale L , Draper Catherine , Palmeira António L , Silva Marlene Nunes , Van Belle Sara , Pawlowski Charlotte S , Schipperijn Jasper , Altenburg Teatske M 
Published: February 2024

IntroductionThe majority of adolescents do not meet guidelines for healthy behaviours, posing major risks for developing multiple non-communicable diseases. Unhealthy lifestyles seem more prevalent in urban than rural areas, with the neighbourhood environment as a mediating pathway. How to develop and implement sustainable and effective interventions focused on adolescent health and well-being in urban vulnerable life situations is a key challenge. This paper describes the protocol of a Youth-centred Participatory Action (YoPA) project aiming to tailor, implement, and evaluate social and physical environmental interventions.Methods and analysisIn diverse urban environments in Denmark, the Netherlands, Nigeria and South Africa, we will engage a dynamic group of 15–20 adolescents (12–19 years) growing up in vulnerable life situations and other key stakeholders (eg, policy makers, urban planners, community leaders) in local co-creation communities. Together with academic researchers and local stakeholders, adolescents will take a leading role in mapping the local system; tailoring; implementing and evaluating interventions during participatory meetings over the course of 3 years. YoPA applies a participatory mixed methods design guided by a novel Systems, User perspectives, Participatory co-creation process, Effects, Reach, Adoption, Implementation and Maintenance framework assessing: (i) the local systems, (ii) user perspectives, (iii) the participatory co-creation process, (iv) effects, (v) reach, (vi) adoption, (vii) implementation and (viii) maintenance of interventions. Through a realist evaluation, YoPA will explore why and how specific outcomes were reached (or not) in each setting (n=800–1000 adolescents in total).Ethics and disseminationThis study received approval from the ethics committees in Denmark, the Netherlands, Nigeria and South Africa and will be disseminated via various collaborative dissemination activities targeting multiple audiences. We will obtain informed consent from all participants. We envision that our YoPA co-creation approach will serve as a guide for participation of adolescents in vulnerable life situations in implementation of health promotion and urban planning in Europe, Africa and globally.Trial registration numberNCT06181162.
Application of the QDST algorithm for the Schrödinger particle simulation in the infinite potential well
Authors: Ostrowski Marcin 
Published: February 2024

AbstractThis paper examines whether a quantum computer can efficiently simulate the time evolution of the Schrödinger particle in a one-dimensional infinite potential well. In order to solve the Schrödinger equation in the quantum register, an algorithm based on the Quantum Discrete Sine Transform (QDST) is applied. The paper compares the results obtained in this way with the results given by the previous method (based on the QFT algorithm).
A Casa da Ponte e o ninho vazio: a geograficidade na poesia de Cora Coralina e Leodegária de Jesus
Authors: Pedreira Pedro Arthur , Silva Valéria Cristina Pereira da 
Published: February 2024

This article came from research from an analysis of four poems book that intend not just trace a parallel between geography and literature, but also identify symbols of the geographic space in Cora Coralina’s and Leodegaria de Jesus’ poetry, two female poetries who lived in the twenty century Cidade de Goiás and were head autor for their literary contribution that shown a lot of city and special aspects where they lived. This tittle remains to symbols used in their poems that shown the feelings for the Cidade de Goiás. This article also wants to identify the influence of the literature in the living space, gazing the Cora Coralina’s Museum and the book store “Leodegaria de Jesus”, respectively a heritage of the most known writer in Goiás and a tribute for the first woman who wrote a poetry book in the state. This study use the phenomenology point of view and analyses space symbols to complain its structure.
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis
Authors: Bashore Alexander C. , Yan Hanying , Xue Chenyi , Zhu Lucie Y. , Kim Eunyoung , Mawson Thomas , Coronel Johana , Chung Allen , Sachs Nadja , Ho Sebastian , Ross Leila S. , Kissner Michael , Passegué Emmanuelle , Bauer Robert C. , Maegdefessel Lars , Li Mingyao , Reilly Muredach P. 
Published: February 2024

BACKGROUND:
Atherosclerotic plaques are complex tissues composed of a heterogeneous mixture of cells. However, our understanding of the comprehensive transcriptional and phenotypic landscape of the cells within these lesions is limited.

METHODS:
To characterize the landscape of human carotid atherosclerosis in greater detail, we combined cellular indexing of transcriptomes and epitopes by sequencing and single-cell RNA sequencing to classify all cell types within lesions (n=21; 13 symptomatic) to achieve a comprehensive multimodal understanding of the cellular identities of atherosclerosis and their association with clinical pathophysiology.

RESULTS:
We identified 25 cell populations, each with a unique multiomic signature, including macrophages, T cells, NK (natural killer) cells, mast cells, B cells, plasma cells, neutrophils, dendritic cells, endothelial cells, fibroblasts, and smooth muscle cells (SMCs). Among the macrophages, we identified 2 proinflammatory subsets enriched in IL-1B (interleukin-1B) or C1Q expression, 2 TREM2-positive foam cells (1 expressing inflammatory genes), and subpopulations with a proliferative gene signature and SMC-specific gene signature with fibrotic pathways upregulated. Further characterization revealed various subsets of SMCs and fibroblasts, including SMC-derived foam cells. These foamy SMCs were localized in the deep intima of coronary atherosclerotic lesions. Utilizing cellular indexing of transcriptomes and epitopes by sequencing data, we developed a flow cytometry panel, using cell surface proteins CD29, CD142, and CD90, to isolate SMC-derived cells from lesions. Lastly, we observed reduced proportions of efferocytotic macrophages, classically activated endothelial cells, and contractile and modulated SMC-derived cells, while inflammatory SMCs were enriched in plaques of clinically symptomatic versus asymptomatic patients.

CONCLUSIONS:
Our multimodal atlas of cell populations within atherosclerosis provides novel insights into the diversity, phenotype, location, isolation, and clinical relevance of the unique cellular composition of human carotid atherosclerosis. These findings facilitate both the mapping of cardiovascular disease susceptibility loci to specific cell types and the identification of novel molecular and cellular therapeutic targets for the treatment of the disease.
Understanding Stokes Drift Mechanism via Crest and Trough Phase Estimates
Authors: Guha Anirban , Gupta Akanksha 
Published: February 2024

Abstract
By providing mathematical estimates, this paper answers a fundamental question—“what leads to Stokes drift”? Although overwhelmingly understood for water waves, Stokes drift is a generic mechanism that stems from kinematics and occurs in any nontransverse wave in fluids. To showcase its generality, we undertake a comparative study of the pathline equation of sound (1D) and intermediate-depth water (2D) waves. Although we obtain a closed-form solution x(t) for the specific case of linear sound waves, a more generic and meaningful approach involves the application of asymptotic methods and expressing variables in terms of the Lagrangian phase θ. We show that the latter reduces the 2D pathline equation of water waves to 1D. Using asymptotic methods, we solve the respective pathline equation for sound and water waves, and for each case, we obtain a parametric representation of particle position x(θ) and elapsed time t(θ). Such a parametric description has allowed us to obtain second-order accurate expressions for the time duration, horizontal displacement, and average horizontal velocity of a particle in the crest and trough phases. All these quantities are of higher magnitude in the crest phase in comparison to the trough phase, leading to a forward drift, i.e., Stokes drift. We also explore particle trajectory due to second-order Stokes waves and compare it with linear waves. While finite amplitude waves modify the estimates obtained from linear waves, the understanding acquired from linear waves is generally found to be valid.
The effectiveness and tolerability of pharmacotherapy for psychosis in 22q11.2 Deletion Syndrome: A systematic review
Authors: Tanham Maya , Chen Renee , Warren Nicola , Heussler Helen , Scott James G 
Published: February 2024

Objective: The 22q11.2 Deletion Syndrome (22q11.2DS) is the most common microdeletion in humans with over 180 phenotypic expressions. Approximately 30–40% of affected individuals will develop psychosis and 25% meet the criteria for schizophrenia. Despite this, pharmacotherapy for managing psychosis in 22q11.2DS is poorly understood and 22q11.2DS psychosis is frequently labelled as treatment resistant. The objectives of this paper are to evaluate the effectiveness and tolerability of pharmacotherapy for 22q11.2DS psychosis and evaluate the evidence for treatment resistance. Method: A systematic search was performed using CINAHL, The Cochrane Library (Cochrane Database of Systematic Reviews; Cochrane Central Register of Controlled Trials and Cochrane Clinical Answers), EMBASE, PsycINFO, PubMed, Scopus and Web of Science Core Collection from inception to December 2022. It yielded 39 case reports, 6 case series and 1 retrospective study which met the inclusion criteria. Results: Based on the current literature, individuals with 22q11.2DS psychosis experience a greater rate of medical co-morbidities such as cardiac arrhythmias, seizures and movement disorders, which complicate pharmacotherapy. Poor tolerability rather than poor clinical response motivates the switching of antipsychotics, which may explain the labelling of treatment resistance in the literature. Conclusion: There are insufficient data to recommend a single antipsychotic for 22q11.2DS psychosis. Nonetheless, with proactive management of co-morbidities, antipsychotic medication in 22q11.2DS psychosis is an effective treatment commonly resulting in improvement in quality of life.
Occurrence and formation of clast-free circular depressions in the southern Namib Desert, Tsau ǁKhaeb (Sperrgebiet) National Park, Namibia
Authors: McAuliffe Joseph R , Jürgens Norbert , Gunter Felicitas , Burke Antje 
Published: February 2024

Circular depressions are concave, shallow depressions found on planar landscape surfaces in the southern Namib Desert. They occur on gravelly substrates with nearly level to very slightly inclined surfaces. The depressions range from 6 to 10 m in diameter with centers typically depressed 10–20 cm below the level of the surrounding terrain. Locations of individual circular depressions were mapped at one site using ground-based measurements and at three additional sites using Google Earth imagery. At all sites, circular depressions are highly overdispersed with densities ranging from approximately 10–20/ha and corresponding nearest neighbor distances of 17–24 m. Large fragments of weathered calcrete and stones occur on soil surfaces surrounding circular depressions, but not within the depressions. Circular depressions at one site contained active burrow systems of Brants’ whistling rat ( Paratomys brantsii). Bioturbation by these rodents contributes to the non-cohesive nature of the sandy substrate, which promotes aeolian deflation and formation of the depressions. Excavations of the burrow systems by the honey badger ( Mellivora capensis) in search of rodent prey can transfer large stones and calcrete fragments from the subsurface to the surface and subsequently move those materials about the surface. Even if such sequential, horizontal displacements are in random directions, such movements can eventually yield a central, clast-free area surrounded by a peripheral zone where the clasts accumulate once they have been displaced beyond the margin of the area to which the predator is drawn in search of rodent prey. A conceptual model consisting of a two-dimensional random walk of large clasts about the surface until they are displaced from the focal “arena” of rodent occupation provides a novel explanation for origin of a spatially organized pattern that is initiated through the random displacement of those materials. Comparable microtopographic patterning associated with bioturbation in other arid and semi-arid environments may have similar origins.
Clinical and Functional Outcomes of Suture Versus Headless Screw Fixation for Tibial Eminence Fractures in Children
Authors: Ercan Niyazi , Arıcan Gökhun , Şibar Kemal , Özmeriç Ahmet , İltar Serkan 
Published: February 2024

Background: Suture and screw fixations are widely used to treat tibial eminence fractures (TEFs). Although a few biomechanical and clinical studies have compared suture fixation (SF) and screw fixation in the treatment of TEFs in children, no comparative clinical studies are available regarding headless screw fixation (HSF). Purpose: To evaluate the clinical and functional outcomes of children with TEF who underwent SF and HSF. Study Design: Cohort study; Level of evidence, 3. Methods: The study included 24 patients treated with either SF (11 patients) or HSF (13 patients) within 1 month of TEF (type 2 or 3) without associated ligamentous and bone injury between 2015 and 2020. All patients were evaluated at a minimum 2-year follow-up in terms of Lysholm score, Tegner activity level, International Knee Documentation Committee subjective score, and isometric strength test. Knee stability was compared based on the Lachman test, pivot-shift test, and KT-1000 arthrometer side-to-side difference. Results: No significant differences were found between the 2 groups in terms of Lysholm score, Tegner activity level, and International Knee Documentation Committee subjective score at follow-up. All patients were able to resume their daily activities within 6 months after the injury. However, flexion deficits (6°-10°) were found in 2 patients in the SF group and 1 patient in the HSF group, and extension deficits (3°-5°) were found in 3 patients in the SF group and 1 patient in the HSF group, without significant intergroup difference. Stability based on the Lachman test, pivot-shift test, and KT-1000 arthrometer side-to-side difference was also similar between the 2 groups at follow-up. No statistically significant difference was found between the 2 groups in isometric tests performed. Conclusion: The present study is the first to compare the clinical and functional results of SF and HSF techniques. The HSF technique demonstrated comparable clinical and functional outcomes, suggesting its potential as an alternative to the SF technique.
Retrospective Review of Complications and Revision Rates Between Isolated Talonavicular vs Talonavicular and Subtalar (Double) Arthrodesis vs Triple Arthrodesis
Authors: Gauthier Chase , Bakaes Yianni , Martinez Matthew , Hardin James , Gonzalez Tyler , Jackson J. Benjamin 
Published: February 2024

Background: Hindfoot fusion procedures are common for the treatment of end-stage arthritis or deformity. Surgical treatments for these conditions include talonavicular joint (single) arthrodesis, talonavicular and subtalar (double) arthrodesis, or talonavicular, subtalar, and calcaneocuboid (triple) arthrodesis. This study evaluated the complication rate, revision surgery rate, and hardware removal rate for those treated with either single, double, or triple arthrodesis. Methods: A retrospective review was conducted for patients who underwent single ( Current Procedural Terminology [ CPT] code 28740), double ( CPT 28725 and 28740), or triple ( CPT 28715) arthrodesis to treat hindfoot arthritis/deformity ( International Classification of Diseases, Ninth Revision [ ICD-9] code: 734, International Classification of Diseases, Tenth Revision [ ICD-10] codes: M76821, M76822, and M76829) from 2005 to 2022 using the South Carolina Revenue and Fiscal Affairs databank. Data collected included demographics, comorbidities, procedure data, and postoperative outcomes within 1 year of principal surgery. Student t test, chi-squared test, and multivariable logistic regression analysis were utilized during data analysis. Results: A total of 433 patients were identified, with 248 undergoing single arthrodesis, 67 undergoing double arthrodesis, and 118 undergoing triple arthrodesis. There was no significant difference between single, double, and triple arthrodesis in the rate of complications, hardware removals, revision surgeries, or 30-day readmission when controlling for confounding variables. However, a decrease in Charlson Comorbidity Index (CCI) was found to be predictive of an increase in the revision surgery rate (OR = 0.46, 95% CI 0.22-0.85, P = .02). Conclusion: We found no difference in the rate of complications, hardware removals, or revision surgeries in those undergoing single, double, or triple arthrodesis. Surprisingly we found that a lower Charlson Comorbidity Index, indicating a healthier patient had a significant relationship with a higher rate of revision surgery. Further study including radiographic indications for surgery or the impact of overall health status on revision surgery rates may further elucidate the other components of this relationship. Level of Evidence: Level III, cohort study.