bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex difference in the risk of extubation failure in ICUs
Authors: Thille Arnaud W. , Boissier Florence , Coudroy Rémi , Le Pape Sylvain , Arrivé François , Marchasson Laura , Frat Jean-Pierre , Ragot Stéphanie ,   for the REVA Research Network, Muller Grégoire , Gacouin Arnaud , Decavèle Maxens , Sonneville Romain , Beloncle François , Girault Christophe , Dangers Laurence , Lautrette Alexandre , Cabasson Séverin , Rouzé Anahita , Vivier Emmanuel , Le Meur Anthony , Ricard Jean-Damien , Razazi Keyvan , Barberet Guillaume , Lebert Christine , Ehrmann Stephan , Sabatier Caroline , Bourenne Jeremy , Pradel Gael , Bailly Pierre , Terzi Nicolas , Dellamonica Jean , Lacave Guillaume , Danin Pierre-Éric , Nanadoumgar Hodanou , Gibelin Aude , Zanre Lassane , Deye Nicolas 
Published: December 2023

Abstract
Background
Little attention has been paid to potential differences in prognosis between mechanically ventilated males and females in intensive care units (ICUs). We hypothesized that a sex gap in the risk of extubation failure in ICUs may exist.

Methods
Post hoc analysis of a large-scale clinical trial including patients at high risk of extubation failure in ICUs, with the aim of assessing the risk of extubation failure according to sex. The primary outcome was reintubation within the 7 days following extubation.

Results
Out of 641 patients, 425 (66%) were males and 216 (34%) were females. Males were more likely to be admitted for cardiac arrest and to have underlying ischemic heart disease whereas females were more likely to be admitted for coma and to have obesity. Whereas the rate of reintubation at 48 h was significantly higher in males than in females (11.0% vs. 6.0%; difference, + 5.0 [95% CI, 0.2 to 9.2]; P = 0.038), the rate of reintubation at day 7 did not significantly differ between males and females (16.7% vs. 11.1%; difference, + 5.6% [95%CI, − 0.3 to 10.8], P = 0.059). Using multivariable logistic regression analysis, male sex was independently associated with reintubation within the 7 days following extubation (adjusted OR 1.70 [95% CI, 1.01 to 2.89]; P = 0.048), even after adjustment on reason for admission, body-mass index, severity score, respiratory rate before extubation, and noninvasive ventilation after extubation.

Conclusion
In this post hoc analysis of a clinical trial including a homogeneous subset of patients at high risk of extubation failure, sex was independently associated with reintubation. The role of sex on outcomes should be systematically examined in future studies of critically ill patients.
Mechanical Properties of Ultra-High Performance Concrete (UHPC) and Ultra-High Performance Fiber-Reinforced Concrete (UHPFRC) with Recycled Sand
Authors: Choi Donguk , Hong Kyungchan , Ochirbud Munkhtuvshin , Meiramov Didar , Sukontaskuul Piti 
Published: December 2023

AbstractUse of high-cost raw materials such as quartz sand can limit wider application of ultra-high performance concrete in concrete construction. In this experimental study, recycled sand was used to fabricate ultra-high performance concrete (UHPC) and ultra-high performance fiber-reinforced concrete (UHPFRC). Green UHPC with ordinary Portland cement and industrial by-products such as silica fume, fly ash, as well as recycled sand was first developed through two-step packing density tests to optimize the mix design. UHPFRC was then developed based on the UHPC mix designs and by using 1%, 2%, or 3% 13-mm straight steel fibers (SSF). The compressive strength, elastic modulus, and flexural tensile strength was 128 MPa, 46.9 GPa, and 11.9 MPa, respectively, after 28 days at water-to-binder ratio of 0.17 and with 2% SSFs. All high-performance concretes in this work utilized 100% commercially available recycled sand that was produced by wet processing method. Mechanical characteristics such as strength, elastic modulus, and density, absorption, and voids of the UHPC/UHPFRC were investigated. Development of autogenous shrinkage of UHPC/UHPFRC with recycled sand was monitored for 12 weeks, while mercury intrusion porosimetry test and scanning electron microscopy were performed for microstructural investigation. Finally, the environmental impacts and economical aspects of the green UHPC were evaluated by life cycle assessment (LCA) and cost analysis.
Experience in the Management of Sigmoid Sinus Thrombophlebitis Secondary to Middle ear Cholesteatoma
Authors: Fei Jing , Peng Xiao-Wen , Yang Ting-Yu , Shen Xue-Li , Gao Lin , Liao Na , Li Lei-Ji 
Published: December 2023

Objective To discuss the management of sigmoid sinus thrombophlebitis secondary to middle ear cholesteatoma. Methods We retrospectively analyzed all cases of sigmoid sinus thrombophlebitis caused by middle ear cholesteatoma over a period of 7 years. 7 male and 2 female patients, ranging in age from 9 to 66 years, were diagnosed with sigmoid sinus thrombophlebitis by clinical presentation and radiological examination. By executing a modified mastoidectomy and tympanoplasty (canal wall-down tympanoplasty) to entirely remove the cholesteatoma-like mastoid epithelium, all patients were effectively treated surgically without opening the sigmoid sinus. All patients were treated with broad-spectrum antibiotics, but no anticoagulants were used. Results 9 patients had otogenic symptoms such as ear pus, tympanic membrane perforation, and hearing loss. In the initial stage of the surgery, modified mastoidectomy and tympanoplasty were performed on 8 of the 9 patients. 1 patient with a brain abscess underwent puncturing (drainage of the abscess) to relieve cranial pressure, and 4 months later, a modified mastoidectomy and tympanoplasty were carried out. Following surgery and medication, the clinical symptoms of every patient improved. After the follow-up of 6 months to 7 years, 3 patients were re-examined for MRV and showed partial sigmoid sinus recovery with recanalization. 4 months following middle ear surgery, the extent of a patient's brain abscess lesions was significantly reduced. 1 patient experienced facial paralysis after surgery and recovered in 3 months. None of the patients had a secondary illness, an infection, or an abscess in a distant organ. Conclusion The key to a better prognosis is an adequate course of perioperative antibiotic medication coupled with surgical treatment. A stable sigmoid sinus thrombus can remain for a long time after middle ear lesions have been removed, and it is less likely to cause infection and abscesses in the distant organs. The restoration of middle ear ventilation is facilitated by tympanoplasty. It is important to work more closely with multidisciplinary teams such as neurology and neurosurgery when deciding whether to perform lateral sinusotomies to remove thrombus or whether to administer anticoagulation. Graphical abstract
Early-Onset Juvenile Nasopharyngeal Angiofibroma (JNA): A Systematic Review
Authors: Newman Matthew , Nguyen Thomas Boi Vu , McHugh Tobial , Reddy Kesava , Sommer Doron Dov 
Published: December 2023

Background Juvenile Nasopharyngeal Angiofibroma (JNA) is a fibrovascular tumor of the nasopharynx that classically presents in adolescent males. The reported mean age of onset is between 13 and 22 years old [1–6]. Significant androgen stimulation is hypothesized to explain the strong predisposition for JNA to present in young adolescent males. However, considerable variability in age at diagnosis exists with rare involvement of very young patients incongruent with typical male pubertal growth patterns. Objective The purpose of this systematic review is to identify cases of early-onset JNA (EOJNA), (defined as age < 10 years) in the literature and to examine the disease characteristics and treatments used in this patient group. A case of a 7 year old boy with EOJNA at our institution is also described and presented. Methods We searched Embase, Cochrane database and MEDLINE from 1996 to February 2021 for studies that reported cases of EOJNA. Relevant clinico-demographic data, disease severity and treatment outcomes were recorded and analyzed using descriptive statistics. We compared our findings with reported means for JNA in all ages. Results We identified 29 studies containing a total of 34 cases of EOJNA. The vast majority (31/34) of patients were males and the mean age of diagnosis was 8.15 years old. The most common presenting symptoms were nasal obstruction (65.2%) and epistaxis (60.9%). Patients were most commonly Radkowski stage II (39.4%) and III (39.4%). Primary treatment modalities included open surgery (66.7%), endoscopic surgery (24.2%), and radiotherapy (9.1%). Recurrence was evident in 30%. Radkowski stage and type of treatment did not differ significantly within the EOJNA group ( p = 0.440 and p = 0.659, respectively). Conclusion This systematic review suggests that rare cases of EOJNA have distinct disease characteristics. Patients in this cohort appeared to have more advanced disease and higher recurrence rates when compared with reported averages. We hope that this review prompts increased clinical awareness of this potentially more aggressive subtype of JNA. As more cases of EOJNA are reported, a more powered statistical analysis of this cohort would be feasible.
Coupled-driven high-speed and high-torque switchable transmission with a large transmission ratio
Authors: Takayama Toshio , Waragai Masaki 
Published: December 2023

AbstractElectric motors are used globally, especially in industrial applications, and achieving high energy efficiency is a major problem. Variable transmissions are effective in reducing the energy consumption of motors, but practical variable transmissions are bulky and heavy, making them unsuitable for robots. To overcome this problem, two motor-driven mechanisms have been proposed. The two motors are operated independently and assigned to the high-speed drive and high-torque drive, and one motor always becomes dead weight. Therefore, we propose a coupled-driven switchable transmission system that can switch the high-speed and high-torque drives by combining the rotation directions and utilizing the output of both motors. The developed device uses two 22-W motors and can switch the reduction ratio from 1/15 to 1/375. The maximum torque, maximum rotation speed, and weight are 10 Nm, 500 rpm, and 905 g, respectively. The experimental results show that the relative speeds of two motors are significant for the coupled drive; nevertheless, this device can be controlled by conventional voltage control without precise speed control.
Comparison of ultrahigh and standard resolution photon-counting CT angiography of the femoral arteries in a continuously perfused in vitro model
Authors: Gruschwitz Philipp , Hartung Viktor , Ergün Süleyman , Peter Dominik , Lichthardt Sven , Huflage Henner , Hendel Robin , Pannenbecker Pauline , Augustin Anne Marie , Kunz Andreas Steven , Feldle Philipp , Bley Thorsten Alexander , Grunz Jan-Peter 
Published: December 2023

Abstract
Background
With the emergence of photon-counting CT, ultrahigh-resolution (UHR) imaging can be performed without dose penalty. This study aims to directly compare the image quality of UHR and standard resolution (SR) scan mode in femoral artery angiographies.

Methods
After establishing continuous extracorporeal perfusion in four fresh-frozen cadaveric specimens, photon-counting CT angiographies were performed with a radiation dose of 5 mGy and tube voltage of 120 kV in both SR and UHR mode. Images were reconstructed with dedicated convolution kernels (soft: Body-vascular (Bv)48; sharp: Bv60; ultrasharp: Bv76). Six radiologists evaluated the image quality by means of a pairwise forced-choice comparison tool. Kendall’s concordance coefficient (W) was calculated to quantify interrater agreement. Image quality was further assessed by measuring intraluminal attenuation and image noise as well as by calculating signal-to-noise ratio (SNR) and contrast-to-noise ratios (CNR).

Results
UHR yielded lower noise than SR for identical reconstructions with kernels ≥ Bv60 (p < 0.001). UHR scans exhibited lower intraluminal attenuation compared to SR (Bv60: 406.4 ± 25.1 versus 418.1 ± 30.1 HU; p < 0.001). Irrespective of scan mode, SNR and CNR decreased while noise increased with sharper kernels but UHR scans were objectively superior to SR nonetheless (Bv60: SNR 25.9 ± 6.4 versus 20.9 ± 5.3; CNR 22.7 ± 5.8 versus 18.4 ± 4.8; p < 0.001). Notably, UHR scans were preferred in subjective assessment when images were reconstructed with the ultrasharp Bv76 kernel, whereas SR was rated superior for Bv60. Interrater agreement was high (W = 0.935).

Conclusions
Combinations of UHR scan mode and ultrasharp convolution kernel are able to exploit the full image quality potential in photon-counting CT angiography of the femoral arteries.

Relevance statement
The UHR scan mode offers improved image quality and may increase diagnostic accuracy in CT angiography of the peripheral arterial runoff when optimized reconstruction parameters are chosen.

Key points
• UHR photon-counting CT improves image quality in combination with ultrasharp convolution kernels.
• UHR datasets display lower image noise compared with identically reconstructed standard resolution scans.
• Scans in UHR mode show decreased intraluminal attenuation compared with standard resolution imaging.

Graphical Abstract
The tug-of-war on iron between plant and pathogen
Authors: Sun Jiaying , Xiao Shuqin , Xue Chunsheng 
Published: December 2023

AbstractIron participates in various crucial metabolic processes as an essential cofactor of many enzymes, which are vital to the survival of plants and their pathogens. However, excessive iron is toxic to the cells of plants and pathogens. Iron plays a complex role in the interactions between plants and pathogens. Plants and pathogens have evolved sophisticated mechanisms to modulate iron status at a moderate level for maintaining fitness. Iron competition extensively exists on both sides of plants and pathogens during infection. Plants employ iron withholding, local iron accumulation, or iron deficiency to trigger resistance against pathogens. Pathogens counteract host-derived iron stress or interfere with plant iron homeostasis to ensure virulence during infection. This review focuses on the recent progress in understanding the roles of iron in plant-pathogen interactions and proposes prospects for future studies.
A literature review addressing midwakh and e-cigarette use in the Gulf region
Authors: Dalibalta Sarah , Makhlouf Zinb , Rabah Layal , Samara Fatin , Elsayed Yehya 
Published: December 2023

AbstractA notable decrease in conventional cigarette smoking has been witnessed on a global scale. However, this decrease has been accompanied by an equally striking global increase in the consumption of alternative tobacco products (ATPs), namely e-cigarettes and midwakh in the Arabian Gulf region. A literature review was used to outline the chemical composition of these two ATPs and review their impacts on health. The study was conducted using databases like PubMed, Google Scholar, MDPI, and WorldCat. The literature search included terms such as “e-cigarettes,” “midwakh,” “dokha,” “heath impacts,” “psychological effects,” “social influences,” and “cigarette smoking” with emphasis on literature from the Arabian Gulf region. Data shows that midwakh contains markedly high levels of tar, nicotine, and various compounds of notable effects on the human body. Similarly, it was found that e-cigarettes contain non-negligible amounts of nicotine and other chemical compounds that may not have been extensively investigated. Alarming reports of system-specific effects brought about by midwakh, and e-cigarette consumption, have been reported, although further research is needed to deduce the mechanism. We also discussed some of the social and psychological factors leading to their consumption within this population. Hence, this review raises questions around the safety of these two types of ATPs and encourages comprehensive studies globally and regionally.
Synthesis and efficacy of cinnamon oil formulations and their sustainable release against common house mosquito larvae
Authors: Mahran Hesham A. , Aboelhadid Shawky M. , Hassan Khaled M. 
Published: December 2023

Abstract
Background
Control of mosquitoes is considered an essential public health priority. This study was designed to estimate the larvicidal activity of two formulations of Cinnamomum zeylanicum EO for controlling Culex pipiens larvae.

Results
The prepared formulations were a nanoemulsion of cinnamon (CNE), cinnamon (CN) alone and ordinary cinnamon essential oil mixed with sesame oil (CSO). The cinnamon + sesame oil (CSO) was added as one part cinnamon to 3 parts SO. Different concentrations were prepared and applied following the WHO larvicidal bioassay protocol. Our findings revealed that the LC50 of the CNE form ranged from 85.3 µg/mL to 28.30 µg/mL. The LC50 of SO alone was 1265 µg/mL but when mixed with CNE to form the CSO mixture, this decreased to 159.00 µg/mL. In terms of residual effect, the ordinary form of cinnamon had a residual effect in water for 72 h at a dose of 1000 µg/ml, but this extended to 120 h at the same dose when the CNE form was used. However CSO did not have a residual effect, however.

Conclusion
The nanoemulsion form significantly improved the efficacy and residual effect of cinnamon against Culex pipiens larvae. Additionally, mixing cinnamon with sesame oil had a synergistic effect. This may assist control strategies against the house mosquito, Culex pipiens.
Isolation and characterization of undescribed flavonoid from Abrus precatorius L. based on HPTLC-DPPH bioautography and its cytotoxicity evaluation
Authors: Ansari Hafsa I. , Dabhi Ranjitsinh C. , Trivedi Pooja G. , Thakar Milan S. , Maru Jayesh J. , Sindhav Gaurang M. 
Published: December 2023

Abstract
Background
Naturally derived compounds play a tremendous role as a drug as well as lead structure for the development of APIs. Therefore, isolation and characterization of compounds from nature are needed to alleviate life-threatening diseases. A. precatorius L. belongs to the family Leguminosae and is valued for its medicinal properties. Therefore, in this study, efforts are being made to isolate bioactive entity based on HPTLC-DPPH bioautography from APHA extract. Among all the separated compounds on TLC plate, the one (APSP-3) at Rf = 0.67 showed significant antioxidant activity, and hence, APSP-3 was further subjected to isolation, purification, and structural characterization using diverse analytical modus operandi such as 1D and 2D NMR, FTIR, HPLC–MS/MS, and elemental analysis. In addition, antioxidant and cytotoxicity evaluation of APHA extract and APSP-3 was pursued by standard DPPH and colorimetric MTT assays, respectively.

Results
Antioxidative isolated compound APSP-3 was scrutinized based on HPTLC-DPPH bioautography. The APSP-3 was found novel and spectroscopic data revealed the plausible structure; 7-hydroxy-3,5-dimethoxy-2-(4-((3,4,5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-2-yl)oxy) phenyl)-4H-chromen-4-one. Moreover, APSP-3 ascribed higher free radical scavenging activity with IC50 = 38.70 ± 3.5 µg/mL than standard ascorbic acid (75.19 ± 1.5 µg/mL). Cytotoxicity evaluation of APHA extract exhibited IC50 value 122.09 µg/mL for HepG2, 122.61 µg/mL for MCF-7, and 48.08 µg/mL for HCT116 cell lines, while APSP-3 displayed IC50 values 96.75 for HepG2, 61.67 for MCF-7, and 47.61 µg/mL for HCT116 cell lines.

Conclusions
In a nutshell, HPTLC-directed bioautography leads to the capturing of new flavonoid entity having antioxidant potency from APHA extract. The IC50 values obtained from cytotoxicity establish a dose–response relationship helping to determine the concentration at which a substance begins to exhibit toxic effects. This fundamental information is crucial for establishing safe dosage level in medical and pharmaceutical applications. Further, research engrossed in assessing other bioactivities involving in silico and in vivo studies obliged to offer a promising and secure portrayal for clinical implications.

Graphical abstract
Impact of the Japanese Government's ‘General Principles of Suicide Prevention Policy’ on youth suicide from 2007 to 2022
Authors: Matsumoto Ryusuke , Motomura Eishi , Shiroyama Takashi , Okada Motohiro 
Published: December 2023

Background
The Japanese Government programme ‘General Principles of Suicide Prevention Policy' (GPSPP) contributed to decreasing suicide mortality rates (SMRs) before the COVID-19 pandemic, but they increased after the pandemic.

Aims
To identify risk factors for youth suicide and the impact of GPSPP on youth suicide.

Method
Annual suicide numbers during 2007–2022 were obtained from government databases. SMRs of student and non-student youths were analysed with a linear mixed-effects model. Interrupted time-series analysis was conducted to investigate temporal relations between three GPSPP periods and SMRs with 52 suicide motives among high school, special vocational school and university students. Multiple regression analysis was conducted to investigate the influence of grade repetition on university student SMRs.

Results
Non-student youth SMRs were higher than student SMRs. School-related (worrying about the future/underachievement), health-related (mainly mental illness) and family-related (conflict with parent and severe verbal reprimands) motives were major motives for student SMRs. During the first GPSPP period (2007–2012), no student SMRs decreased. During the second period (2012–2017), university and special vocational school student SMRs increased, but high school student SMRs were unchanged. In contrast, during the third period (2017–2022), with the exception of male special vocational school students, all SMRs increased. Unexpectedly, long-term grade repetition was negatively associated with health-related SMRs.

Conclusions
These findings suggest that GPSPP-supported programmes in schools partially contributed to student suicide prevention. To suppress increasing student SMRs, social/life support specialists should participate in in-school support services to bolster the social standing and lives of students who repeat grades or experience setbacks.
A Rare Case When Acromegaly Meets Cushing Syndrome
Authors: Gabbay Jacob , Steinmetz-Wood Samantha , Chamorro-Pareja Natalia , Barrett Kaitlyn 
Published: December 2023

Abstract
Acromegaly is very uncommon, as is non-iatrogenic Cushing syndrome; we discuss a patient who was found to have both a pituitary adenoma causing acromegaly and a cortisol-producing adrenal adenoma causing Cushing syndrome within 1 year. She was a healthy, 44-year-old woman who presented with visual changes and was found to have bitemporal hemianopsia and a 3.3-cm pituitary mass along with central hypogonadism, central hypothyroidism, and suppressed adrenocorticotropin and discrepant cortisol. After transsphenoidal resection she had declining, but persistently elevated, insulin-like growth factor 1 (IGF-1), raising concern for persistent acromegaly. She also was experiencing several cushingoid symptoms and was found to have elevated salivary and urinary cortisol. An abdominal computed tomography scan showed a 3.1-cm adrenal adenoma, and she subsequently underwent adrenalectomy. Following adrenalectomy, her cortisol levels normalized, and her IGF-1, growth hormone, and oral glucose tolerance test showed substantial improvement consistent with previous reports linking hypercortisolism and elevated IGF-1 levels. Combinations of pituitary and adrenal disease are seen in a handful of genetic syndromes; however, her clinical presentation and genetics do not fit with known syndromes. This case describes two rare endocrine tumors in one patient and associated limitations of routine laboratory testing.