bluuebunny/crossref_metadata_2025_split huggingface dataset:
NODULAR FASCIITIS OF FACE: A CASE REPORT
Authors: Irshad Zarghuna , Sohail Saphra , Khan Muhammad Hatam , Iqbal Sofia 
Published: February 2025

The case of an 18 year old female patient from Peshawar with Nodular Fasciitis is reported. Our aim is to highlight the importance of understanding this rare disease, as it is crucial in the management of this condition and saves the patient from more invasive treatment.
FREQUENCY OF HYPOTHYROIDISM AMONG WOMEN PRESENTING WITH PREECLAMPSIA
Authors: Amina Noor Ul , AKBAR SAIMA , Shah Sumayya , Saleem Javeria 
Published: February 2025

Objective: To determine the frequency of hypothyroidism among women presenting with Preeclampsia.
Methods: We conducted this cross-sectional study in Gynecology and Obstetrics unit, Khyber Teaching Hospital, Peshawar. A total of 369 patients (age above) with preeclampsia were selected meeting the inclusion criteria, through non-probability sampling and serum TSH and T4 measurements done in these.
Results: Total 369 women presenting with Preeclampsia with mean age was 33.02 years ± 7.50. Among total sample about 26 (7.05%) patients had hypothyroidism.
Conclusion: Women with hypothyroidism identified during pregnancy have an increased risk for severe Preeclampsia.
Keywords: Hypothyroidism, Preeclampsia, eclampsia, blood pressure, pregnant women
Unveiling the Functional Component in Post-Concussive Cognitive Impairment: A Novel Modelling Approach
Authors: Mavroudis Ioannis , Chatzikonstantinou Symela , Petridis Foivos , Kazis Dimitrios , Kamal Fatima Zahra , Diaconu Sorina , Visternicu Malina , Ciobica Alin , Iordache Alin , Stadoleanu Carmen , Dacia Petroaie Antoneta , Novac Bogdan 
Published: February 2025

<p dir="ltr"><span>Mild traumatic brain injury (mTBI) is a common public health problem that significantly affects millions of people, especially people in high-risk occupations. Post-concussive cognitive impairment (PCCI) is a prevalent and debilitating outcome of mTBI that has a major impact on cognitive function as well as quality of life, thus affecting long-term health outcomes. Of all traumatic brain injuries, mTBI accounts for 58-88%, according to epidemiological studies. However, mTBI sufferers report a multitude of cognitive and emotional symptoms that constitute post-concussive syndrome (PCS). The most reported symptoms include fatigue, headaches, sensitivity to noise, anxiety, and depression. Although there is progress in understanding biochemical and structural changes after mTBI, memory, attention, and processing speed in PCCI remain poorly understood. This study aims to develop a regression model based on the modified version of Brown's disease cognition model. This model describes both cognitive and behavioural responses as indicators of functional aspects in PCS. In this study, data from 45 patients were analysed to reveal the functional nature of cognitive impairment in PCS, to open the way for more precise interventions. In addition to investigating the physiological aspects of PCS, we aim to recognise the inherent social dimension of the experiences of individuals affected by PCS. Additionally, the often subtle and non-observable nature of symptoms can bring challenges in interpersonal relationships, emphasising the need to enhance awareness among family, colleagues, and employers of the cognitive and behavioural aspects of PCS.</span></p><div><span><br /></span></div>
La perception du personnel scolaire quant à la formation et à la préparation pour agir de manière inclusive en contexte pluriethnique1
Authors: Potvin Maryse , Querrien Diane , De Koninck Zita 
Published: February 2025

Cet article fait état d’une enquête interrégionale sur la formation du personnel scolaire à la prise en compte de la diversité ethnoculturelle, religieuse et linguistique et à ses impacts sur les compétences interculturelles et inclusives, selon les perceptions de six catégories de personnels en éducation au Québec : futurs enseignants et enseignantes, personnel enseignant en exercice depuis moins de 5 ans, responsables de formation pratique (stages) et maitres associés, conseillers et conseillères pédagogiques, et directions d’établissements primaires et secondaires (Potvin et al., 2020). Reposant sur les concepts de « sentiment de compétence » et de « compétences » interculturelles et inclusives, les résultats relèvent des situations pour lesquelles les personnes répondantes, surtout les plus expérimentées, se sentent (ou estiment le personnel scolaire) moins bien préparées à agir ou à intervenir en raison de leur formation théorique et pratique. C’est le cas notamment des situations qui font partie de l’actualité criante et des polémiques publiques, de nature davantage sociologique, éthique ou juridique (liées aux droits) plutôt que pédagogique ou didactique : les situations d’accommodements raisonnables, de radicalisation et d’adaptation de leurs interventions pour tenir compte des réalités et besoins des enfants réfugiés ou provenant de zones de guerre.
"Floral" symbolism in the lyrics of Arseny Tarkovsky
Authors: Popova Mariia , Skvortsova Anna 
Published: February 2025

The subject of this article is the "floral" symbolism involved in the lyrics of Arseny Tarkovsky (a poet belonging to the "secondary current" of the Silver Age). In particular, the symbolism of roses and lilacs in his works is especially closely examined. The object of painstaking analysis are selected poems by Arseny Tarkovsky, Taffy and Igor Severyanin. The intertextual connections of A. Tarkovsky's lyrics with individual poems by Taffy and I. Severyanin (poets who are dissimilar, but united by the era of modernism in which they had to live and create) are noted. The purpose of this study is to find certain patterns in the references to floral symbols by Arseny Tarkovsky and other poets of the Silver Age, to establish intertextual links between them, and to study individual features characteristic of the mentality of this period. In this article, which explores the "floral" symbolism of Arseny Tarkovsky's lyrics, comparative historical, intertextual and motivic research methods are used. The novelty of the research lies in the establishment of intertextual links between the lyrics of A. Tarkovsky, which mention "floral" symbolism, with the poems of Taffy and I. Severyanin. It is concluded that Tarkovsky's poetry frequently mentions roses and lilacs. They are mentioned in connection with the phenomenon of recollection, sometimes even "false" recollection, traditionally expressing feelings of a loving nature. Roses are usually a symbol of earthly and heavenly love, fullness of life, very rarely witnessing the last farewell of the lyrical hero with his beloved. Lilac by A. Tarkovsky and I. Severyanin is also a guide to the chronotope of the past, while remaining a very specific sensual image, which is revealed in all its splendor, in all its tangibility, as well as a symbol of first love. Among other things, lilac has unexpectedly similar "light" associations in A. Tarkovsky and Taffy. The "floral" references to roses and lilacs have a dual nature in all these authors art: palpably sensual, acmeistic and symbolic.
Efficacy and Safety of 5-Day Oral Ensitrelvir for Patients With Mild to Moderate COVID-19
Authors: Yotsuyanagi Hiroshi , Ohmagari Norio , Doi Yohei , Yamato Masaya , Bac Nguyen Hoang , Cha Bong Ki , Imamura Takumi , Sonoyama Takuhiro , Ichihashi Genki , Sanaki Takao , Tsuge Yuko , Uehara Takeki , Mukae Hiroshi 
Published: February 2024

ImportanceTreatment options for COVID-19 are warranted irrespective of the presence of risk factors for severe disease.ObjectiveTo assess the efficacy and safety of ensitrelvir in patients with mild to moderate COVID-19.Design, Setting, and ParticipantsThis phase 3 part of a phase 2/3, double-blind, placebo-controlled randomized clinical trial was conducted from February 10 to July 10, 2022, with a 28-day follow-up period, at 92 institutions in Japan, Vietnam, and South Korea. Patients (aged 12 to &amp;lt;70 years) with mild to moderate COVID-19 within 120 hours of positive viral test results were studied.InterventionsPatients were randomized (1:1:1) to receive 125 mg of once-daily ensitrelvir (375 mg on day 1), 250 mg of once-daily ensitrelvir (750 mg on day 1), or placebo for 5 days.Main Outcomes and MeasuresThe primary end point was the time to resolution of the composite of 5 characteristic symptoms of SARS-CoV-2 Omicron infection, assessed using a Peto-Prentice generalized Wilcoxon test stratified by vaccination history. Virologic efficacy and safety were also assessed.ResultsA total of 1821 patients were randomized, of whom 1030 (347 in the 125-mg ensitrelvir group, 340 in the 250-mg ensitrelvir group, and 343 in the placebo group) were randomized in less than 72 hours of disease onset (primary analysis population). The mean (SD) age in this population was 35.2 (12.3) years, and 552 (53.6%) were men. A significant difference was observed between the 125-mg ensitrelvir group and the placebo group (P = .04 with a Peto-Prentice generalized Wilcoxon test). The difference in median time was approximately 1 day between the 125-mg ensitrelvir group and the placebo group (167.9 vs 192.2 hours; difference, −24.3 hours; 95% CI, −78.7 to 11.7 hours). Adverse events were observed in 267 of 604 patients (44.2%) in the 125-mg ensitrelvir group, 321 of 599 patients (53.6%) in the 250-mg ensitrelvir group, and 150 of 605 patients (24.8%) in the placebo group, which included a decrease in high-density lipoprotein level (188 [31.1%] in the 125-mg ensitrelvir group, 231 [38.6%] in the 250-mg ensitrelvir group, and 23 [3.8%] in the placebo group). No treatment-related serious adverse events were reported.Conclusions and RelevanceIn this randomized clinical trial, 125-mg ensitrelvir treatment reduced the time to resolution of the 5 typical COVID-19 symptoms compared with placebo in patients treated in less than 72 hours of disease onset; the absolute difference in median time to resolution was approximately 1 day. Ensitrelvir demonstrated clinical and antiviral efficacy without new safety concerns. Generalizability to populations outside Asia should be confirmed.Trial RegistrationJapan Registry of Clinical Trials Identifier: jRCT2031210350
The Impact of Occupational Therapy on the Self‐Management of Rheumatoid Arthritis: A Mixed Methods Systematic Review
Authors: Gavin James P. , Rossiter Laura , Fenerty Vicky , Leese Jenny , Adams Jo , Hammond Alison , Davidson Eileen , Backman Catherine L. 
Published: February 2024

ObjectiveTo determine the impact of occupational therapy (OT) on the self‐management of function, pain, fatigue, and lived experience for people living with rheumatoid arthritis (RA).MethodsFive databases and gray literature were searched up to June 30, 2022. Three reviewers screened titles and abstracts, with two independently extracting and assessing full texts using the Cochrane risk of bias (quantitative) and Critical Appraisal Skills Programme (qualitative) tools to assess study quality. Studies were categorized into four intervention types. Grading of Recommendations, Assessment, Development and Evaluations (GRADE) (quantitative) and GRADE‐ Confidence in Evidence from Reviews of Qualitative research (qualitative) were used to assess the quality of evidence for each intervention type.ResultsOf 39 eligible papers, 29 were quantitative (n = 2,029), 4 qualitative (n = 50), and 6 mixed methods (n = 896). Good evidence supports patient education and behavior change programs for improving pain and function, particularly group sessions of joint protection education, but these do not translate to long‐term improvements for RA (>24 months). Comprehensive OT had mixed evidence (limited to home OT and an arthritis gloves program), whereas limited evidence was available for qualitative insights, splints and assistive devices, and self‐management for fatigue.ConclusionAlthough patient education is promising for self‐managing RA, no strong evidence was found to support OT programs for self‐managing fatigue or patient experience and long‐term effectiveness. More research is required on lived experience, and the long‐term efficacy of self‐management approaches incorporating OT, particularly timing programs to meet the individual's conditional needs (i.e., early or established RA) to build on the few studies to date.
Mechanoluminescence and Mechanical Quenching of Afterglow Luminescent Particles for Wearable Photonic Display
Authors: Kim Seong‐Jong , Yang Fan , Jung Ho Sang , Hong Guosong , Hahn Sei Kwang 
Published: February 2024

AbstractOptical properties of afterglow luminescent particles (ALPs) in mechanoluminescence (ML) and mechanical quenching (MQ) have attracted great attention for diverse technological applications. However, these unique phenomena need to be more clearly explained for the specific photonic application. Here, ALPs are designed for the development of a wearable and rewritable photonic display system as a communication toolbox under dark conditions or underwater environments with limited communication. This display system demonstrates long‐lasting MQ after short ML along the handwritten trajectories with mechanical pressure and the written content can be easily erased by short UV light irradiation, preserving the system integrity with the high reproducibility of ML and MQ responses. The effect of trapped electrons and the recharging process on the ML and MQ is assessed, which provides insights into their underlying mechanisms. In addition, this display system exhibits remarkable resistance to humidity and retains its rewritable and photonic capabilities underwater for a long‐term period. Furthermore, the rewritable property of display system on human skin is demonstrated, confirming their effectiveness as a wearable photonic display system. Taken together, this research will pave a big new avenue to develop biophotonic materials for various biomedical applications with mechano‐optical conversions.
Periodic Lamellae‐Based Nanofibers for Precise Immunomodulation to Treat Inflammatory Bone Loss in Periodontitis
Authors: He Ze , Liu Yao , Zheng Zi‐Li , Lv Jia‐Cheng , Liu Shi‐Bo , Zhang Ju , Liu Hang‐Hang , Xu Jia‐Zhuang , Li Zhong‐Ming , Luo En 
Published: February 2024

AbstractPeriodontitis is a common oral disease accompanied by inflammatory bone loss. The pathological characteristics of periodontitis usually accompany an imbalance in the periodontal immune microenvironment, leading to difficulty in bone regeneration. Therefore, effective treatment strategies are needed to modulate the immune environment in order to treat periodontitis. Here, highly‐oriented periodic lamellae poly(ε‐caprolactone) electrospun nanofibers (PLN) are developed by surface‐directed epitaxial crystallization. The in vitro result shows that the PLN can precisely modulate macrophage polarization toward the M2 phenotype. Macrophages polarized by PLN significantly enhance the migration and osteogenic differentiation of Bone marrow stromal cells. Notably, results suggest that the topographical cues presented by PLN can modulate macrophage polarization by activating YAP, which reciprocally inhibits the NF‐κB signaling pathway. The in vivo results indicate that PLN can inhibit inflammatory bone loss and facilitate bone regeneration in periodontitis. The authors’ findings suggest that topographical nanofibers with periodic lamellae is a promising strategy for modulating immune environment to treat inflammatory bone loss in periodontitis.
Human Omental Mature Adipocytes used as Paclitaxel Reservoir for Cell‐Based Therapy in Ovarian Cancer
Authors: Andele Pacome K. , Palazzolo Stefano , Corona Giuseppe , Caligiuri Isabella , Kamensek Urska , Cemazar Maja , Canzonieri Vincenzo , Rizzolio Flavio 
Published: February 2024

AbstractPrimary human omental adipocytes and ovarian cancer(OC) cells establish a bidirectional communication in which tumor driven lipolysis is induced in adipocytes and the resulting fatty acids are delivered to cancer cells within the tumor microenvironment. Despite meaningful improvement in the treatment of OC, its efficacy is still limited by hydrophobicity and untargeted effects related to chemotherapeutics. Herein, omental adipocytes are firstly used as a reservoir for paclitaxel, named Living Paclitaxel Bullets (LPB) and secondly benefit from the established dialogue between adipocytes and cancer cells to engineer a drug delivery process that target specifically cancer cells. These results show that mature omental adipocytes can successfully uptake paclitaxel and deliver it to OC cells in a transwell coculture based in vitro model. In addition, the efficacy of this proof‐of‐concept has been demonstrated in vivo and induces a significant inhibition of tumor growth on a xenograft tumor model. The use of mature adipocytes can be suitable for clinical prospection in a cell‐based therapy system, due to their mature and differentiated state, to avoid risks related to uncontrolled cell de novo proliferation capacity after the delivery of the antineoplastic drug as observed with other cell types when employed as drug carriers.
Peptide‐Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy
Authors: Duan Xiaolin , Wang Pin , He Lulu , He Zhen , Wang Shiwei , Yang Fang , Gao Changyong , Ren Wenzhi , Lin Jie , Chen Tianxiang , Xu Chen , Li Juan , Wu Aiguo 
Published: February 2024

AbstractThe diagnosis and treatment of solid tumors have undergone significant advancements marked by a trend toward increased specificity and integration of imaging and therapeutic functions. The multifaceted nature of inorganic oxide nanomaterials (IONs), which boast optical, magnetic, ultrasonic, and biochemical modulatory properties, makes them ideal building blocks for developing multifunctional nanoplatforms. A promising class of materials that have emerged in this context are peptide‐functionalized inorganic oxide nanomaterials (PFIONs), which have demonstrated excellent performance in multifunctional imaging and therapy, making them potential candidates for advancing solid tumor diagnosis and treatment. Owing to the functionalities of peptides in tumor targeting, penetration, responsiveness, and therapy, well‐designed PFIONs can specifically accumulate and release therapeutic or imaging agents at the solid tumor sites, enabling precise imaging and effective treatment. This review provides an overview of the recent advances in the use of PFIONs for the imaging and treatment of solid tumors, highlighting the superiority of imaging and therapeutic integration as well as synergistic treatment. Moreover, the review discusses the challenges and prospects of PFIONs in depth, aiming to promote the intersection of the interdisciplinary to facilitate their clinical translation and the development of personalized diagnostic and therapeutic systems by optimizing the material systems.
Efficient Dual Mechanisms Boost the Efficiency of Ternary Solar Cells with Two Compatible Polymer Donors to Exceed 19%
Authors: Liu Shizhao , Wang Junjie , Wen Shuguang , Bi Fuzhen , Zhu Qianqian , Yang Chunpeng , Yang Chunming , Chu Junhao , Bao Xichang 
Published: February 2024

AbstractTernary strategyopens a simple avenue to improve the power conversion efficiency (PCE) of organic solar cells (OSCs). The introduction of wide bandgap polymer donors (PDs) as third component canbetter utilize sunlight and improve the mechanical and thermal stability of active layer. However, efficient ternary OSCs (TOSCs) with two PDs are rarely reported due to inferior compatibility and shortage of efficient PDs match with acceptors. Herein, two PDs‐(PBB‐F and PBB‐Cl) are adopted in the dual‐PDs ternary systems to explore the underlying mechanisms and improve their photovoltaic performance. The findings demonstrate that the third components exhibit excellent miscibility with PM6 and are embedded in the host donor to form alloy‐like phase. A more profound mechanism for enhancing efficiency through dual mechanisms, that are the guest energy transfer to PM6 and charge transport at the donor/acceptor interface, has been proposed. Consequently, the PM6:PBB‐Cl:BTP‐eC9 TOSCs achieve PCE of over 19%. Furthermore, the TOSCs exhibit better thermal stability than that of binary OSCs due to the reduction in spatial site resistance resulting from a more tightly entangled long‐chain structure. This work not only provides an effective approach to fabricate high‐performance TOSCs, but also demonstrates the importance of developing dual compatible PD materials.
Prediction of Phase Composition and Process Resilience in Plasma‐Assisted Hetero‐Aggregate Synthesis using a Machine‐Learning Model with Multivariate Output
Authors: Lu Yuanqing , Fazletdinov Timur , Pan Zhiwen , Wondraczek Katrin , Wondraczek Lothar 
Published: February 2024

AbstractThe synthesis of nanoscale particles and particle aggregates from liquid or gaseous precursors is affected by a variety of trade‐off relations, for example, in terms of product composition, yield, or energy efficiency. Machine‐supported process evaluation and learning (ML) of these relations enables optimization strategies for advanced material processing. Such a workflow is demonstrated on the example of plasma‐assisted aerosol deposition (PAAD) of alumina powders. Depending on processing conditions, these powders comprise of hetero‐aggregate mixtures of crystalline and amorphous polymorphs. Process optimization toward a specific target composition calls for ML approaches. For this, a sufficiently large and consistent dataset of PAAD input (processing) and output (product) parameters is initially generated by real‐world processing, and subsequently extrapolated into a cloud of ≈106 input‐output parameter matrices using Gaussian process regression with multivariate output and input‐output feature analysis. It is subsequently demonstrated how not only the phase composition of the obtained alumina powders, but also product resilience to variations in specific processing parameters, or – as a perspective – the energy efficiency of material processing can be predicted.
Flexible Self‐Powered Organic Photodetector with High Detectivity for Continuous On‐Plant Sensing
Authors: Schrickx Harry M. , Gyurek Sydney , Moore Caleb , Hernández‐Pagán Edmaritz , Doherty Colleen J. , Kudenov Michael W. , O'Connor Brendan T. 
Published: February 2024

AbstractOrganic photodetectors (OPDs) exhibit performance on par with inorganic detectors (e.g., Si) but can be ultrathin, ultra‐lightweight, flexible, and mechanically resilient, opening up opportunities for novel applications including optical sensors for continuous human and plant health monitoring. Here, a high‐performance flexible self‐powered OPD designed for on‐plant optical sensing is developed. The OPD employs an electrode consisting of Ag nanowires (NWs) embedded in a UV‐curable resin to achieve a flexible and thin form factor. In addition, the OPD active layer consisting of D18‐Cl and Y6 is sequentially cast to reduce dark current. The flexible OPD is sensitive to 400–950 nm wavelengths and exhibits photodetector characteristics comparable to state‐of‐the‐art rigid OPDs. The responsivity reaches values of 0.47 A W−1 and specific detectivity exceeds 1012 Jones. Owing to the embedded Ag NW electrodes in a thin substrate (t = 20 µm) and sequentially cast active layers, the detector demonstrates excellent bending stability. The photocurrent remains steady across 4000 cycles with a bending radius of 2 mm. The flexible OPD is demonstrated to effectively detect plant uptake of the rare‐earth metal terbium and sense time‐dependent chlorophyll fluorescence. Thus, this work highlights the potential for OPDs as on‐plant sensors to advance precision agriculture.