bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of antiresorptive/antiangiogenic therapy on changes in periodontal and oral tissue structures: a histomorphometrical analysis in rats
Authors: Ramanauskaite Ausra , Mangold Katharina , Padhye Ninad , Obreja Karina , Borschert Fanya , Dahmer Iulia , Schwarz Frank 
Published: November 2023

Abstract
Objective
The objective of this study was to investigate the influence of various antiresorptive and antiangiogenic medications on morphological changes in periodontal and oral tissue structures.

Materials and methods
Fifty-five Wistar rats randomly received dual application (i.e., at baseline and after 12-weeks) one of the following medications: (1) amino-bisphosphonate [zoledronate (Zo)], (2) RANKL inhibitor [denosumab (De)], (3) antiangiogenic [bevacizumab (Be)], (4) Zo + Be, (5) De + Be or (6) no medication [Control (Co)]. Periodontal and oral tissue biopsies were obtained at 17 (n = 21 animals, Phase 1, (De = 3, De + Be = 3, Zo = 5, Be = 3, Zo + Be = 2, Co = 5) and 29 (n = 34 animals, (De = 8, De + Be = 6, Zo = 2, Be = 7, Zo + Be = 4, Co = 7, Phase 2) weeks after the second drug application. The following outcomes were histomorphometrically assessed: periodontal space width in the coronal (PLS-C, mm) and apical sections (PLS- A), number of empty alveolar bone lacunae in the coronal, apical sections and at the apex at respective tooth sites (EL – C, EL- A, EL- Ap), mucosal thickness at edentulous alveolar ridge areas (MT, mm), and, when present, associated areas of inflammatory cell infiltrates (ICI, mm2).

Results
Comparable mean PLS-C, PLS-A, ET-A, ET-C, ET-Ap, and MT values were observed in all experimental groups after Phases 1 and 2. The presence of ICI was identified in 3 animals in the Co group (Phase 1: 1, Phase 2: 2), and 17 animals in the test groups (Phase 1: 4; Phase 2: 14). The estimated ICI surface area was significantly higher in the Zo + Be group, followed by the Zo and Be groups compared to that measured in the Co group. The time (i.e., Phases 1 and 2) was not found to be a predictor for the extent of the ICI area. In all groups, the EL-C, EL-A, and EL-Ap values were significantly higher after Phase 2 compared to those assessed after Phase 1. The MT values were significantly reduced in all groups after Phase 2 compared to those measured after Phase 1.

Conclusions
The present evaluation was not able to find any morphological effects of different antiresorptive and antiangiogenic medications on periodontal and oral tissue structures. The presence of inflammatory cell infiltrates was more frequently observed in the animals administered with antiresorptive and antiangiogenic medications as well as combinations thereof.

Clinical relevance
Administration of antiresorptive and antiangiogenic medications may be capable of inducing inflammatory reactions in periodontal tissues.
Rapid detection of cefiderocol susceptibility/resistance in Acinetobacter baumannii
Authors: Raro Otávio Hallal Ferreira , Bouvier Maxime , Kerbol Auriane , Decousser Jean-Winoc , Poirel Laurent , Nordmann Patrice 
Published: November 2023

Abstract
Purpose
Due to its ability to disseminate worldwide and its multiple resistance trait, Acinetobacter baumannii is becoming a threat for public health worldwide. Cefiderocol (FDC) is a promising broad-spectrum cephalosporin recently approved for treating Gram-negative infection. The aim of this study was to develop a rapid test, namely the rapid FDC Acinetobacter baumannii NP test, for the detection of FDC susceptibility/resistance in A. baumannii since the current FDC susceptibility tests are rather time-consuming (at least 24 h).

Materials and methods
The rapid test is based on the reduction of resazurin to resorufin product by bacterial viable cells, thus detecting bacterial growth in the presence of FDC (38.4 mg/L). A color change from blue (resazurin) to violet or pink (resorufin) represents visual detection of bacterial growth. 95 randomly selected A. baumannii isolates were used to evaluate the performance of the rapid FDC Acinetobacter baumannii NP test.

Results
The test showed 95.5% (95% CI 78.2–99.2%) and 100.0% (95% CI 95.0–100.0%) of sensitivity and specificity, respectively. All the results were obtained within 4 h30–4 h45 incubation time at 35 °C ± 2 °C, saving virtually one day when compared with currently-used antimicrobial susceptibility tests. The test showed only a single very major error, an isolate with a MIC of 8 mg/L.

Conclusions
The rapid FDC Acinetobacter baumannii NP test can be a valuable method which is easier and faster to interpret when compared with the gold standard broth microdilution method. The test showed remarkable performances; hence, it may be suitable for implementation in clinical microbiology routine laboratories.
Heat Transfer Analysis of Full-Scale Safe Rooms Exposed to Bushfire Conditions
Authors: Hendawitharana Sahani , Ariyanayagam Anthony , Mahendran Mahen 
Published: November 2023

AbstractSheltering in place is identified as an accepted behaviour during disasters while safe rooms are purpose-built buildings used for sheltering or storage of valuables under these circumstances. However, ensuring the integrity of safe rooms in bushfires is complex and challenging due to many factors. This study aims to advance the understanding of the bushfire fire heat transfer in steel framed bushfire safe rooms using a numerical modelling approach. Both small-scale models of individual external walls and full-scale models of safe rooms were developed and validated using the results of an experimental study of a full-scale safe room. Then the study was extended to address the identified challenges in the design of safe rooms influenced by the factors such as, the fire exposed area, internal compartment arrangement, location of the safe room in the bushfire-prone areas, and the external environmental temperatures during summer on the tenability requirements. The results of this study provide considerable details of the performance of above-ground bushfire safe rooms detached from the associated dwelling under realistic fire conditions. They showed that the integrity of the doors is very important and that having multiple internal compartments is favourable for the bushfire performance of safe rooms. This study shows that safe rooms can be constructed using available building materials to satisfy the bushfire heat transfer requirements and provides conditions for their usage. Furthermore, the modelling methods emphasise their applicability to evaluate safe rooms and modular buildings in bushfire and building fire related scenarios.
Competition on hold? How competing discourses shape academic organisations in times of crisis
Authors: Buschkamp Leonie , Seidenschnur Tim 
Published: November 2023

AbstractThis research deals with the question of how the Covid-19 pandemic affected discourses on competition in higher education organisations and how other discourses occurred and gained power. Additionally, it focusses on changes which take place in windows of opportunities that occur through discursive change in times of crisis. We show that discourses on competition have been highly influential in the field of academia. However, the pandemic rapidly introduced or empowered new or different discourses. These discourses either replaced existing discourses on competition, ascribed different meanings or redefined the frame under which a specific discourse is important. We merge our observations of such processes into the argument that the Covid-19 crisis has put competition discourses on hold during the first stage of the pandemic. At later stages, we show that competition discourses regained power. To make these contributions, we analyse interviews conducted at two universities at the organisational leadership level and in different departments in subjects such as social sciences, product design, music and engineering. We also examine official statements by the German rectors’ conference and further documents such as emails and press releases at two stages of the pandemic crisis. The first stage took place during the lockdowns in 2020 and gives us rich insights into the changes during the pandemic. The second stage took place in 2022 when organisations returned at least partly to their pre-pandemic routines allowing us to analyse changes over time.
The Role of Wearable Sensors in the Future Primary Healthcare – Preferences of the Adult Swiss Population: A Mixed Methods Approach
Authors: Matti Corinne , Essig Stefan , Föhn Zora , Balthasar Andreas 
Published: November 2023

AbstractWearable sensors have the potential to increase continuity of care and reduce healthcare expenditure. The user concerns and preferences regarding wearable sensors are the least addressed topic in related literature. Therefore, this study aimed first, to examine the preferences of the adult Swiss population regarding the use of wearable sensors in primary healthcare. Second, the study aimed to explain and learn more about these preferences and why such wearable sensors would or would not be used. An explanatory sequential design was used to reach the two aims. In the initial quantitative phase preferences of a nationwide survey were analyzed descriptively and a multivariable ordered logistic regression was used to identify key characteristics, that influence the preferences. In the second phase, eight semi-structured interviews were conducted. The cleaned study sample of the survey included 687 participants, 46% of whom gave a positive rating regarding the use of wearable sensors. In contrast, 44% gave a negative rating and 10% were neutral. The interviews showed that sensors should be small, not flashy and be compatible with everyday activities. Individuals without a current health risk or existing chronic disease showed lower preferences for using wearable sensors, particularly because they fear losing control over their own body. In contrast, individuals with increased risk or with an existing chronic disease were more likely to use wearable sensors as they can increase the personal safety and provide real-time health information to physicians. Therefore, an important deciding factor for and against the use of wearable sensors seems to be the perceived personal susceptibility for potential health problems.
Benchmark Glycan Profile of Therapeutic Monoclonal Antibodies Produced by Mammalian Cell Expression Systems
Authors: Luo Shen , Zhang Baolin 
Published: November 2023

Abstract
Purpose
This study aims to establish a benchmark glycan profile for commercial therapeutic monoclonal antibodies (mAbs) approved by the US Food and Drug Administration (FDA).

Methods
We conducted a rigorous comparison of glycosylation data from the regulatory submissions for FDA-approved therapeutic antibodies up to May 2023. This analysis includes over 150 mAbs produced by various mammalian cell expression systems.

Results
The study identified nine prevalent glycan epitopes across all FDA-approved monoclonal antibodies produced by different expression systems. These epitopes include terminal N-acetylglucosamine, core fucose, terminal galactose, high mannose, α-galactose, terminal α2,3-linked N-acetylneuraminic acid, terminal α2,6-linked N-glycolylneuraminic acid, triantennary structure, and bisecting N-acetylglucosamine, thus establishing a benchmark glycan profile.

Conclusions
The findings of this study have significant implications for therapeutic antibody development, quality control, and regulatory compliance. The benchmark glycan profile enables the assessment of glycosylation consistency and comparability across a diverse range of antibody products, ensuring improved product quality within the biopharmaceutical industry.
Product Market Cooperation, Foreign Direct Investment and Consumer Welfare
Authors: Mukherjee Arijit , Sinha Uday Bhanu 
Published: November 2023

AbstractCooperation among rival firms raises serious skepticism among economists, policymakers, and legal experts, since it generally hurts consumers. We show that this may not be the case in an open economy with strategic foreign direct investment (FDI). Under Cournot competition, increased cooperation among firms reduces the domestic welfare, but it may benefit the consumers by attracting FDI. Under Bertrand competition with differentiated goods, increased cooperation may increase consumer surplus, and it may increase or decrease the domestic welfare by attracting FDI.
Functional diffusion maps
Authors: Barroso M. , Alaíz C. M. , Torrecilla J. L. , Fernández A. 
Published: November 2023

AbstractNowadays many real-world datasets can be considered as functional, in the sense that the processes which generate them are continuous. A fundamental property of this type of data is that in theory they belong to an infinite-dimensional space. Although in practice we usually receive finite observations, they are still high-dimensional and hence dimensionality reduction methods are crucial. In this vein, the main state-of-the-art method for functional data analysis is Functional PCA. Nevertheless, this classic technique assumes that the data lie in a linear manifold, and hence it could have problems when this hypothesis is not fulfilled. In this research, attention has been placed on a non-linear manifold learning method: Diffusion Maps. The article explains how to extend this multivariate method to functional data and compares its behavior against Functional PCA over different simulated and real examples.
Dimension-independent spectral gap of polar slice sampling
Authors: Rudolf Daniel , Schär Philip 
Published: November 2023

AbstractPolar slice sampling, a Markov chain construction for approximate sampling, performs, under suitable assumptions on the target and initial distribution, provably independent of the state space dimension. We extend the aforementioned result of Roberts and Rosenthal (Stoch Model 18(2):257–280, 2002) by developing a theory which identifies conditions, in terms of a generalized level set function, that imply an explicit lower bound on the spectral gap even in a general slice sampling context. Verifying the identified conditions for polar slice sampling yields a lower bound of 1/2 on the spectral gap for arbitrary dimension if the target density is rotationally invariant, log-concave along rays emanating from the origin and sufficiently smooth. The general theoretical result is potentially applicable beyond the polar slice sampling framework.
Efficient probabilistic reconciliation of forecasts for real-valued and count time series
Authors: Zambon Lorenzo , Azzimonti Dario , Corani Giorgio 
Published: November 2023

AbstractHierarchical time series are common in several applied fields. The forecasts for these time series are required to be coherent, that is, to satisfy the constraints given by the hierarchy. The most popular technique to enforce coherence is called reconciliation, which adjusts the base forecasts computed for each time series. However, recent works on probabilistic reconciliation present several limitations. In this paper, we propose a new approach based on conditioning to reconcile any type of forecast distribution. We then introduce a new algorithm, called Bottom-Up Importance Sampling, to efficiently sample from the reconciled distribution. It can be used for any base forecast distribution: discrete, continuous, or in the form of samples, providing a major speedup compared to the current methods. Experiments on several temporal hierarchies show a significant improvement over base probabilistic forecasts.
Phytotoxic impact of bifunctionalized silver nanoparticles (AgNPs-Cit-L-Cys) and silver nitrate (AgNO3) on chronically exposed callus cultures of Populus nigra L.
Authors: Iori Valentina , Muzzini Valerio Giorgio , Venditti Iole , Casentini Barbara , Iannelli Maria Adelaide 
Published: November 2023

AbstractOwing to the unique physicochemical properties and the low manufacturing costs, silver nanoparticles (AgNPs) have gained growing interest and their application has expanded considerably in industrial and agricultural sectors. The large-scale production of these nanoparticles inevitably entails their direct or indirect release into the environment, raising some concerns about their hazardous aspects. Callus culture represents an important tool in toxicological studies to evaluate the impact of nanomaterials on plants and their potential environmental risk. In this study, we investigated the chronic phytotoxic effects of different concentrations of novel bifunctionalized silver nanoparticles (AgNPs-Cit-L-Cys) and silver nitrate (AgNO3) on callus culture of Populus nigra L., a pioneer tree species in the riparian ecosystem. Our results showed that AgNPs-Cit-L-Cys were more toxic on poplar calli compared to AgNO3, especially at low concentration (2.5 mg/L), leading to a significant reduction in biomass production, accompanied by a decrease in protein content, a significant increase in both lipid peroxidation level, ascorbate peroxidase (APX), and catalase (CAT) enzymatic activities. In addition, these findings suggested that the harmful activity of AgNPs-Cit-L-Cys might be correlated with their physicochemical properties and not solely attributed to the released Ag+ ions and confirmed that AgNPs-Cit-L-Cys phytoxicity is associated to oxidative stress.
Overcoming Obstacles: Barriers to Virtual Care Use Among Video-Enabled Tablet Recipients in the Veterans Health Administration
Authors: Wray Charlie M. , Ferguson Jacqueline M. , Greene Liberty , Griffin Ashley , Van Campen James , O’Shea Amy MJ , Slightam Cindie , Zulman Donna M. 
Published: November 2023

Abstract
Introduction
The Veterans Health Administration (VHA) distributes video-enabled tablets to individuals with barriers to accessing care. Data suggests that many tablets are under-used. We surveyed Veterans who received a tablet to identify barriers that are associated with lower use, and evaluated the impact of a telephone-based orientation call on reported barriers and future video use.

Methods
We used a national survey to assess for the presence of 13 barriers to accessing video-based care, and then calculated the prevalence of the barriers stratified by video care utilization in the 6 months after survey administration. We used multivariable modeling to examine the association between each barrier and video-based care use and evaluated whether a telephone-based orientation modified this association.

Results
The most prevalent patient-reported barriers to video-based care were not knowing how to schedule a visit, prior video care being rescheduled/canceled, and past problems using video care. Following adjustment, individuals who reported vision or hearing difficulties and those who reported that video care does not provide high-quality care had a 19% and 12% lower probability of future video care use, respectively. Individuals who reported no interest in video care, or did not know how to schedule a video care visit, had an 11% and 10% lower probability of being a video care user, respectively. A telephone-based orientation following device receipt did not improve the probability of being a video care user.

Discussion
Barriers to engaging in virtual care persist despite access to video-enabled devices. Targeted interventions beyond telephone-based orientation are needed to facilitate adoption and engagement in video visits.
Forschungsethische Praxis in der Kommunikations- und Medienwissenschaft – ein Einblick in die Sicht der Forschenden
Authors: Roehse Eva-Maria , Möhring Wiebke , Zillich Arne Freya , Schlütz Daniela , Link Elena 
Published: November 2023

ZusammenfassungIn der (fach-)öffentlichen Debatte der quantitativ forschenden deutschen Kommunikations- und Medienwissenschaft spielten forschungsethische Fragen bisher eine eher untergeordnete Rolle. Im Kontext von fachinternen Methodenentwicklungen und gesellschaftlichen Diskursen über gute wissenschaftliche Praxis rücken derzeit jedoch auch forschungsethische Fragen in den Blick des Fachs. Vor diesem Hintergrund werden Ergebnisse einer Online-Befragung von empirisch forschenden Kommunikations- und Medienwissenschaftler*innen (N = 186) vorgestellt. Sie entstanden im Rahmen des vom Bundesministerium für Bildung und Forschung geförderten Verbundprojekts „Forschungsethik in der Kommunikations- und Medienwissenschaft“. Die Ergebnisse ermöglichen Einsicht in den Stellenwert und den Umgang mit forschungsethischen Fragen im Kontext eigener Forschung, Lehre und Betreuung. Auch mögliche Einflussfaktoren werden untersucht. Insgesamt zeigte sich, dass die Befragten der Forschungsethik einen gewissen Stellenwert beimessen und weitgehend Konsens darüber besteht, dass ihre Relevanz in Zukunft noch zunehmen wird. Dennoch wird das Thema auch kontrovers gesehen.
Karriereaspirationen und Kompetenzniveaus im pädagogischen Wissen: Zum Zusammenhang zwischen motivationalen Merkmalen und Erwerb professionellen Wissens von (angehenden) Lehrkräften
Authors: Klemenz Stefan , König Johannes 
Published: November 2023

ZusammenfassungWährend die einzelnen Komponenten professioneller Kompetenz von Lehrer*innen – affektiv-motivationale Merkmale und professionelles Wissen – bereits Gegenstand mehrerer Forschungsarbeiten waren, wurde das Verhältnis zwischen ihnen bislang noch nicht intensiv untersucht. Im Anschluss daran werden in dem Beitrag Zusammenhänge zwischen Karriereaspirationen als Teil beruflicher Motivation von (angehenden) Lehrer*innen und dem Erwerb pädagogischen Wissens in den Fokus gerückt. Verwendet wird eine Stichprobe von 321 angehenden sowie bereits berufstätigen Lehrkräften aus Deutschland und Österreich, deren pädagogisches Wissen über drei Messzeitpunkte im Turnus von zwei Jahren mit dem TEDS‑M Testinstrument erfasst wurde. Die Ergebnisse zeigen, dass Karriereaspirationen mit Bezug zu professioneller Entwicklung und Weiterbildung einen positiven Zusammenhang zum Wissensaufbau aufweisen. Dies trifft auf Führungsaspirationen und den anvisierten Verbleib im Lehrer*innenberuf nicht zu. Ferner verdeutlichen Analysen auf Basis eines Kompetenzniveaumodells, dass Karriereaspirationen besonders stark in Zusammenhang mit der Erreichung des höchsten Kompetenzniveaus, das als wichtige Grundlage für die professionelle Entwicklung von Lehrer*innen angesehen werden kann, stehen.
Molecular pathogenesis, mechanism and therapy of Cav1 in prostate cancer
Authors: Bian Qiang , Li Bei , Zhang Luting , Sun Yinuo , Zhao Zhankui , Ding Yi , Yu Honglian 
Published: November 2023

AbstractProstate cancer is the second incidence of malignant tumors in men worldwide. Its incidence and mortality are increasing year by year. Enhanced expression of Cav1 in prostate cancer has been linked to both proliferation and metastasis of cancer cells, influencing disease progression. Dysregulation of the Cav1 gene shows a notable association with prostate cancer. Nevertheless, there is no systematic review to report about molecular signal mechanism of Cav1 and drug treatment in prostate cancer. This article reviews the structure, physiological and pathological functions of Cav1, the pathogenic signaling pathways involved in prostate cancer, and the current drug treatment of prostate cancer. Cav1 mainly affects the occurrence of prostate cancer through AKT/mTOR, H-RAS/PLCε, CD147/MMPs and other pathways, as well as substance metabolism including lipid metabolism and aerobic glycolysis. Baicalein, simvastatin, triptolide and other drugs can effectively inhibit the growth of prostate cancer. As a biomarker of prostate cancer, Cav1 may provide a potential therapeutic target for the treatment of prostate cancer.