bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening Cognition, Sleep, and Physical Activity in Pediatric Oncology Long‐Term Follow‐Up Care
Authors: Oswald‐McCloskey Kaitlin A. , Kubinec Nicole , Heinrich Kimberley 
Published: February 2025

ABSTRACTBackgroundChildren treated for pediatric cancer are at risk for cognitive late effects, as well as impairments in sleep and physical activity. The aim of the present study was to examine the psychometric properties of clinical screening of child‐ and caregiver‐reported cognitive functioning, sleep, and physical activity and the relationship between cognitive functioning and health behaviors within a pediatric oncology long‐term follow‐up clinic.ProcedureThe study included a retrospective chart review of 99 caregivers and 80 children (8–17 years old) who completed the Conners Short Form (parent only) and PROMIS cognitive functioning, sleep‐related impairment, sleep disturbance, and physical activity scales at the child's annual long‐term follow‐up visit. Test statistics and T‐tests were used to assess psychometrics of the PROMIS scales. Bivariate correlations were used to examine the relationship between cognitive function and health behaviors.ResultsThe child‐ and parent‐report, short‐version PROMIS cognitive functioning, sleep, and physical activity scales demonstrated high internal consistency and inter‐rater reliability. High convergent validity was observed between PROMIS cognitive functioning and Conners Short Form. Caregiver‐ and child‐reported cognitive functioning and health behaviors were significantly related (p ≤ 0.042).ConclusionsThe PROMIS short‐version scales are reliable and valid measures for screening cognitive function and health behaviors in pediatric oncology long‐term follow‐up care. Further research examining the predictive validity and longitudinal utility of the PROMIS scales in survivors is warranted. There was a positive association between cognitive functioning and health behaviors in survivors, warranting further investigation to inform potential targets of intervention in long‐term follow‐up care.
Comparative Analysis of Data‐Driven Rescoring Platforms for Improved Peptide Identification in HeLa Digest Samples
Authors: Castaño Jesus D. , Beaudry Francis 
Published: February 2025

ABSTRACTMass spectrometry is a critical tool to understand complex changes in biological processes. Despite significant advances in search engine technology, many spectra remain unassigned. This research evaluates the performance of three rescoring platforms, Oktoberfest, MS2Rescore, and inSPIRE, using MaxQuant output. The results indicated a substantial increase in identifications at the peptide level (40%–53%) and PSM level (64%–67%). However, some peptides were lost due to limitations in processing posttranslational modifications (PTMs)—with up to 75% of lost peptides exhibiting PTMs. Each platform displayed distinct strengths and weaknesses. For instance, inSPIRE performed best in terms of peptide identifications and unique peptides, while MS2Rescore performed better for PSMs at higher FDR values. Differences in platform performance stemmed from different sources: original search engine feature selection, type of ion series predicted, retention time predictor, and PTMs compatibility. Overall, inSPIRE showed a superior ability to harness original search engine results. Taken all together, rescoring platforms clearly outperformed original search results; however, they demanded additional computation time (up to 77%) and manual adjustments. The findings here underline the necessity of integrating rescoring platforms into current proteomics pipelines but also address some challenges in their implementation and optimization. Future integrated platforms may help enhance adoption.
N‐Alkylation of 4‐Hydroxy‐3,5‐Dinitropyrazole: A Facile Route for the Synthesis of Insensitive Energetic Materials
Authors: Bhatia Prachi , Das Priyanka , Kumar Dheeraj 
Published: February 2025

ABSTRACTBehind the synthesis of any new high‐energy density material is the objective to achieve equilibrium between energy and stability, which becomes laborious because of their adversarial nature. Nitropyrazoles, with their viable syntheses and easy modifiability, have been adopted typically as backbones to achieve this goal. However, the acidic nature of pyrazole NH in nitropyrazoles limits their usefulness despite exhibiting appealing characteristics. 4‐Hydroxy‐3,5‐dinitropyrazole (HODNP) is an interesting skeleton because of the presence of the hydroxy functionality in between two nitro groups, which not only provides additional oxygen content for better energy output but also possesses the quality of exhibiting strong hydrogen bonding interactions and tuning of properties via salt formation. N‐alkylation is the most straightforward technique for the protection of the unwanted acidic proton, in addition to making them more physically stable. In this work, we have synthesized N‐methylated and N,N’‐ethylene‐bridged derivatives (2 and 7) of HODNP. Mono and dicationic salts 3‐6 and 8‐11 were also synthesized to boost their performance further. N‐methylated neutral compound 2 and its ammonium salt were confirmed through 15N NMR analysis, and 2 was also confirmed with single‐crystal analysis. All the compounds showed excellent physical stability (IS >40 J, FS > 360 N), and most of the compounds showed good thermal stability (Td > 180°C). The detonation characteristics were found to be similar to the ones found for 1,3,5‐triamino‐2,4,6‐trinitrobenzene (Dv = 7704–8172 m/s, p = 22.4–27.3 GPa).
Effect of Initial Crack Position on Low‐intensity Impact Ignition Performance of Solid Propellant
Authors: Yu Hongtao , Zhang Xiaojing , Zhang Fukun , Meng Yang , Ye Shunan 
Published: February 2025

ABSTRACTThe micro‐crack defects produced in the process of storage and use of solid propellants have an important influence on the safety of solid propellants. In this study, the low‐intensity impact ignition performance of crack‐containing hydroxyl‐terminated polybutadiene (HTPB) propellant was studied. According to the typical HTPB solid propellant formula, the mesoscopic models of defect‐free HTPB propellant and HTPB propellant with different crack positions were established. The Cohesive element was inserted globally. The friction heat generation inside the material and microcracks, the deformation heat generation of ammonium perchlorate (AP) particles and the exothermic reaction of AP particles were considered. The drop hammer impact process of HTPB propellant with crack defects was simulated, and the influence of initial crack position on the low‐intensity impact ignition response time of solid propellant was studied. The results show that the ignition response time of the defect‐free HTPB propellant is 0.38 ms, and the ignition temperature is 621 K; the ignition time of HTPB propellant with crack defects in AP particles, interface, and matrix is 0.33, 0.34, and 0.36 ms, respectively. The ignition temperature is 578, 584, and 597 K.
Investigation of the mechanisms involved in the biocontrol activities of natural products from a marine soil bacterium against rice blast
Authors: Fei Liwang , Hafeez Rahila , Zhang Junliang , Fu Shiquan , Xu Ying , Hao Lingyun 
Published: February 2025

AbstractBACKGROUNDRice blast, caused by Pyricularia oryzae, is a devastating fungal disease threatening global rice production. Overreliance on chemical fungicides has raised environmental concerns and led to resistant strains, necessitating the development of sustainable alternatives. This study integrated marine microbiology and natural antifungal compounds to create eco‐friendly alternatives to chemical fungicides for disease management.RESULTSWe identified Pseudomonas aeruginosa R64 with broad‐spectrum antimicrobial activity from mangrove soil in the Mai Po Nature Reserve. The R64 fermentation extract (RFE) exhibited multifaceted inhibition of P. oryzae, suppressing mycelial growth, conidiation, conidial germination and appressorial formation, while disturbing cell wall and membrane function. It also attenuated virulence by impairing appressorial penetration and invasive growth. Further chemical analysis identified phenazines and quinolines as the primary compounds in RFE, corroborated by PCR detection of corresponding phenazine biosynthetic gene clusters. Comparative bioassays with two main bioactive components of RFE, phenazine‐1‐carboxamide (PCN) and phenazine‐1‐carboxylic acid (PCA), against P. oryzae implicated PCN as the principal antifungal effector. RFE and PCN had higher efficacy than tricyclazole in P. oryzae growth inhibition, but were less effective than isoprothiolane. Furthermore, RFE and PCN displayed lower acute ecotoxicity to an environmental indicator organism than isoprothiolane, suggesting their potential as sustainable biopesticides for rice blast management.CONCLUSIONNatural products from mangrove soil bacterium P. aeruginosa R64 inhibited key developmental and infection processes of P. oryzae, effectively reducing rice blast development. The promising disease inhibition and low ecotoxicity of mangrove‐associated bacteria highlight their untapped potential for innovative, eco‐friendly fungicide mining for sustainable agriculture. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Disposition effect in group versus individual investors: Evidence from Kenyan stock exchange
Authors: Kano Mercy , Muradoğlu Gülnur , Olukuru John 
Published: February 2025

AbstractThis paper studies group behavior and disposition effect. Nairobi Securities Exchange constitutes an excellent setting for analyzing group behavior of investors, who trade jointly as investment groups. Using a proprietary database from the Central Depository and Settlement Corporation (CDSC) containing all retail equity transactions from 2016, we compared the trading behavior of groups and individuals. The results show that group investors exhibit a significantly lower disposition effect than individual investors. Disposition effect increases with frequency of trade and reduces with age. Implications are important in terms of further work on groupthink and group polarization in the context of investments.
Co‐Design of Watermarking and Controller for Reducing Detection Delay of Replay Attacks
Authors: Xia Chenggang , Liu Kun , Wang Haojun , Liu Tao , Li Juntao , Xia Yuanqing 
Published: February 2025

ABSTRACTThis paper investigates the problem of reducing the detection delay of the replay attacks by co‐designing the watermarking signal and the controller parameters. Based on the dynamic encryption‐decryption scheme, we propose a cumulative sum test, which utilizes the sensor measurements and watermarking signals to detect the replay attacks, and derive the relationship between the detection delay and the watermarking signal covariance. Then, we analyze the control performance loss caused by the watermarking signal added to the sensor measurements to expose the replay attacks. Furthermore, to reduce the detection delay, an optimization problem is formulated to design the optimal covariance of the watermarking signal with a tolerable control performance loss. Finally, we reformulate another optimization problem of co‐designing the watermarking signal and the controller parameters to simultaneously reduce the detection delay and the control performance loss. A numerical example is provided to verify the effectiveness of theoretical results.
Carbon Quantum Dots with Tunable Size and Fluorescence Intensity for Development of a Nano‐biosensor
Authors: Park So Yeon , Tan Justin Kok Soon , Mo Xuancheng , Song Yujin , Lim Jiaqi , Liew Xuan Ru , Chung Hyunsoo , Kim Sangho 
Published: February 2025

AbstractCarbon quantum dots (CQDs) are a class of nanomaterials known for their remarkable photostability, chemical inertness and biocompatibility. Changing their size, structure, and surface chemistry enable the tuning of their luminescence property, which gives them tremendous potential for various applications. CQDs synthesis typically involves long tedious processes, requiring multiple steps and harsh reaction conditions. Here, a new reliable, economical, and ultra‐rapid one‐step fabrication method is introduced to obtain CQDs with well‐defined and reproducible photoluminescence properties via a simple heat treatment. These solid‐state CQDs are homogenous in size and are ready to use without the need for further purification. The size of the fabricated CQDs and their corresponding peak fluorescence intensity are confirmed to be tunable by simple adjustment of the heat treatment conditions. Coupled with their selective fluorescence quenching by metal ions, the clinical potential of CQDs is demonstrated for biosensing applications by designing a new nano‐biosensor to assess the quality of stored blood units through hemolysis quantification without disrupting storage conditions. This may pave the way for a new standard in blood bank inventory management.
Interaction Between Strain and Phase Formation in HfxZr1‐xO2 Thin Films
Authors: Wunderwald Florian , Xu Bohan , Kersch Alfred , Holsgrove Kristina M. , Kao Yu‐Cheng , Richter Claudia , Enghardt Stefan , Mikolajick Thomas , Schroeder Uwe 
Published: February 2025

AbstractHfxZr1‐xO2 thin films have excellent complementary metal–oxide semiconductor compatibility and scalability compared to other ferroelectric materials. This makes them a promising candidate for non‐volatile memory applications. However, the polymorphism of the materials presents a challenge in stabilizing the ferroelectric properties. Since the wake‐up free non‐volatile memory applications require the presence of ferroelectric properties in the pristine state of the films without additional electric field cycling, it is necessary to understand how to promote the ferroelectric orthorhombic phase formation. In this work, the interaction between in‐plane tensile strain and phase formation of atomic layer deposition grown HfxZr1‐xO2 thin films with different thicknesses and different compositions is demonstrated. By combining the biaxial in‐plane tensile strain with the electric switching field and remanent polarization, it is observed that the best ferroelectric properties correlated with an in‐plane tensile strain range of 0.4–0.6%. Moreover, the observed correlation between strain and phase formation indicates that strain exerts an influence on phase formation in the pristine state, and that phase formation, in turn, affects strain during electrical field cycling. This work is expected to be helpful to improve the ferroelectric properties in HfxZr1‐xO2 films, which can be processed for different memory devices with specialized requirements.
A Novel Multicompartment Barrier‐Free Microfluidic Device Reveals the Impact of Extracellular Matrix Stiffening and Temozolomide on Immune‐Tumor Interactions in Glioblastoma
Authors: Bayona Clara , Olaizola‐Rodrigo Claudia , Sharko Vira , Ashrafi Mehran , Barrio Jesús del , Doblaré Manuel , Monge Rosa , Ochoa Ignacio , Oliván Sara 
Published: February 2025

AbstractThe immune system plays a crucial role in shaping the glioblastoma tumor microenvironment, characterized by its complexity and dynamic interactions. Understanding the tumor‐immune crosstalk is essential for advancing cancer research and therapeutic development. Here, a novel multicompartment, barrier‐free microfluidic device is presented that overcomes the limitations of existing models by enabling direct tumor‐immune interactions without physical barriers, preserving natural immune cell infiltration. This platform supports the independent and simultaneous culture of tumor and immune cells, replicating the healthy‐tumoral stroma interface, and allows investigating the effect of matrix stiffness and chemotherapy on both populations. The findings reveal that increased collagen concentration promotes tumor invasiveness while impairing immune cell infiltration. Additionally, temozolomide treatment reduces immune cell motility but enhances anti‐tumor immune responses. These insights highlight the critical roles of extracellular matrix mechanics and chemotherapy in tumor progression and immune modulation, establishing this device as a powerful tool for studying glioblastoma‐immune dynamics and evaluating therapeutic strategies.
Advanced Adaptive Protein Membrane with Super‐High Flux and Precise Molecular Sieving of Dyes from Salts
Authors: Zhang Zhaoqian , Sun Hao , Xin Shaopeng , Hu Qiaoxia , Wang Jian , Hu Yunxia 
Published: February 2025

AbstractPrecise separation of small organic molecules and electrolyte salts is critical for various industrial processes, necessitating advanced membranes with uniform pores. Proteins, as one typical nature polymer having the exactly same structure and molecular weight, offer a promising material for making such membranes. Here, hemoglobin (BHb) and lysozyme (Lyz) are utilized to fabricate precise nanofiltration membranes through amyloid‐like co‐assembly, triggered by Tris(2‐carboxyethyl) phosphine. Molecular dynamics simulations reveal that BHb intercalates between Lyz molecules, enhancing tight assembly and reducing defects. The Lyz/BHb membrane exhibits a high void volume of 27.2% and achieves an exceptional permeance of 335 L m−2 h−1 bar−1. Amazingly, the Lyz/BHb membrane achieves ultra‐selective molecular sieving of dyes and salts with an unparalleled high separation factor of 1.25 × 103 for the NaCl/Brilliant blue. The unique adaptive separation layer is formed by anchoring dye molecules into the larger pores and thus narrowing down the pore size distribution and enhancing electrostatic repulsion, endowing the membrane with a distinctive molecular sieving of dyes and salts. This study offers valuable insights to finely tailor the pore structure of the membrane by co‐assembly of proteins and to significantly enhance the membrane perm‐selectivity by creating an adaptive protein separation layer with a unique molecular sieving property.
Controllable Syntheses, Structure Identifications, and Property Explorations of Self‐Intercalated 2D Transition Metal Chalcogenides
Authors: Cheng Yujin , Quan Wenzhi , Wang Jialong , Peng You , Zhou Tong , Ding Haoxuan , Zhang Yanfeng 
Published: February 2025

Abstract2D transition metal dichalcogenides (2D TMDCs) have attracted intensive interest in physics and materials science‐related fields, due to their exotic properties (e.g., superconductivity, charge density wave (CDW) phase transition, magnetism, electrocatalytic property). Intercalation of native metal atoms in the layered 2D TMDCs (e.g., from VS2 to V5S8 by V intercalation) can afford new stoichiometric ratios, phase states, and thus rich properties. This review hereby summarizes the recent progress in the controllable syntheses, structure characterizations, and property explorations of self‐intercalated 2D transition metal chalcogenides (TMCs), with the metal elements focusing on group‐V, VI, and VIII metals. The self‐intercalation‐related synthetic strategies will be introduced via chemical vapor deposition (CVD) and molecule beam epitaxy (MBE), especially by tuning the chemical potentials of intercalated metal elements, growth promoters, substrates, etc. Additionally, the structure/phase identifications of the self‐intercalated 2D TMCs through various characterization techniques will be overviewed. More significantly, the intriguing properties in such 2D TMCs will be thoroughly discussed, such as the thickness‐ or composition‐dependent magnetism, CDW phase transition, electrocatalytic property, etc. Finally, challenges and prospects are proposed for developing new self‐intercalated 2D materials and their heterostructures and exploring their unique properties and applications.
Effects of Various Physical Field–Assisted Techniques and Combination Methods on Extraction of Flavonoids and Polyphenols From Angelica keiskei
Authors: Sun Guoxiu , Wang Jiaqi , Wang Ningning , Zhao Shengnan , Zhao Yuting , Yan Yunqing , Tang Shuwei , Li Zichao 
Published: February 2025

ABSTRACTAngelica keiskei has been well documented as a promising resource rich in bioactive chemicals, especially flavonoids. Field‐assisted extraction and their hybrids have been proved to be advanced approaches for the efficient utilization of flavonoids compared to conventional extraction methods. The current study aims to optimize the extraction conditions of the flavonoids from A. keiskei through high‐pressure processing, ultrasound‐assisted extraction, and microwave‐assisted extraction. Furthermore, taking total flavonoid content, total phenolic content, and antioxidant activity as indexes, three combination methods, high‐pressure processing combined with ultrasound‐assisted extraction, high‐pressure processing combined with microwave‐assisted extraction, and ultrasound‐assisted extraction combined with microwave‐assisted extraction, were further investigated and compared to enhance the extraction efficiency. The results indicate that the A. keiskei extracts obtained by ultrasound‐assisted extraction combined with microwave‐assisted extraction have the optimal total flavonoid content (41.671 mg/g) and total phenolic content (12.071 mg/g), as well as the strongest antioxidant activity. Scanning electron microscopy analyses reflect that the ultrasound‐assisted extraction combined with microwave‐assisted extraction treatment imposed the most pronounced damage to A. keiskei, in which the particles were changed into the smaller size. In vitro experiments for A. keiskei extracts demonstrate that it can effectively inhibit α‐amylase and tyrosinase, suggesting its potential hypoglycemic and whitening activity. This study demonstrates that A. keiskei extracts may serve as a possible source of antioxidants, whereas ultrasound‐assisted extraction combined with microwave‐assisted extraction might represent an innovative and advantageous method for flavonoid extraction from A. keiskei.
Isolation, LC–MS/MS, NMR Characterization, In Silico Toxicity, and ADME Evaluation of Stress‐Degradation Products of Sunitinib With Optimized Stability‐Indicating HPLC Method for Quantification of Sunitinib and its Impurities
Authors: Shaik Rasheed Babu , Devi Dharmasoth Rama , Basavaiah K. , Rao B. M. 
Published: February 2025

ABSTRACTSunitinib belongs to the tyrosine kinase inhibitors class of medical drugs prescribed to treat various types of cancers, including renal cell carcinoma, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors by blocking the action of enzymes that promote cancer cell growth. Forced degradation studies are crucial for assessing drug stability and will be helpful in drug discovery and development. In this study, sunitinib underwent different stress testing according to ICH guidelines to identify and analyze its degradation products (DPs). The stress study findings proved that sunitinib is highly sensitive to acid (2DPs), base (1 DP), and oxidation (1 DP) degradation but remains stable in other stress conditions with significantly less degradation. The separation of sunitinib and its impurities and four DPs was achieved using a Waters XBridge C18 column (250 mm × 4.6 mm, 5 µm) with 0.7 mL/min gradient flow of ammonium formate buffer (pH 4.8) and acetonitrile with a detection wavelength of 258 nm. These conditions produce well‐retained and resolved peaks corresponding to sunitinib at 8.4 min, whereas 4.8, 3.5, and 1.9 min are noticed for impurities 1, 2, and 3, respectively. These study findings provide a comprehensive analysis of sunitinib, its impurities, and DPs, offering crucial insights into its stability and toxicity that can enhance drug development and safety profiling. The study also detailed the degradation pathway of sunitinib, its impurities, and the fragmentation patterns of DPs, which had not been previously reported in any other studies. All these four DPs belong to Class 4 (moderate) toxicity with distinct pharmacokinetic profiles. Hence, it can be concluded that these study findings provide a comprehensive analysis of sunitinib, its impurities, and DPs, offering crucial insights into its stability and toxicity that can enhance drug development and safety profiling.