bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of pharmacist impact on a multidisciplinary transitions of care service in Bundled Payments for Care Improvement Advanced model patients
Authors: Butler Tasha A. , Heiman Elise , Bianco Jessica , Blanco Delilah , Carris Nicholas W. , Martinez Amanda 
Published: October 2023

AbstractIntroductionRecent evidence shows pharmacist interventions on transitional care teams may reduce 30‐ and 90‐day readmissions.ObjectivesThe objective of this study was to evaluate the impact of a virtual multidisciplinary transitional care team including pharmacy services provided to Bundled Payment for Care Improvement Advanced (BPCI‐A) model patients.MethodsThis pre–post implementation retrospective cohort study included adult BPCI‐A patients with traditional Medicare and at least one of eight selected diagnosis‐related groups as the principal admitting diagnosis (sepsis, renal failure, stroke, seizure, urinary tract infection, cellulitis, chronic obstructive pulmonary disease, or pneumonia). The pre‐implementation time period was July 2021 through September 2021, and the post‐implementation time period was November 2021 through March 2022. The primary outcome was the difference between unplanned 90‐day revisits among BPCI‐A patients who received care from the multidisciplinary transitional care team (including pharmacy) versus patients receiving no care from the multidisciplinary transitional care team.ResultsOverall, patients (n = 201) were elderly (mean age ~ 73 years), evenly split male/female (51%), and Caucasian (~73%). Sepsis was the most common principal diagnosis pre‐implementation (n = 26; 28%) and stroke was the most common principal diagnosis post‐implementation (n = 33, 31%). Elixhauser comorbidity index was similar between cohorts. Pre‐implementation, 32% of patients (n = 29) had an unplanned revisit within 90 days versus 27% (n = 28) post‐implementation (p = 0.453). Pre‐implementation, 18% of patients experienced a 30‐day unplanned revisit versus 19% of patients post‐implementation (p = 0.890). The average length of stay for unplanned revisits was 7.4 days in the pre‐implementation cohort versus 8.2 days in the post‐implementation cohort (p = 0.846).ConclusionNo difference was identified in revisits pre‐ versus post‐implementation. The study may have been impacted by seasonal variation or small sample size as a 5% absolute decrease in revisits is clinically meaningful. Larger and longer studies to optimize readmission prevention strategies are needed.
A case of fulminant type 1 diabetes masquerading acute pancreatitis
Authors: Matsuura Naoki , Yoshino Shumpei , Morisaki Hiroko 
Published: October 2023

AbstractFulminant type 1 diabetes is a novel and life‐threatening subtype of type 1 diabetes characterized by its markedly abrupt onset and hyperglycemia with a relatively low glycated hemoglobin level at the onset. We herein describe a typical case of fulminant type 1 diabetes who presented with abdominal pain and vomiting, and whose laboratory test revealed elevated pancreatic enzymes. He was initially diagnosed with acute pancreatitis, but occult and prolonged hyperglycemia eventually led to a diagnosis of fulminant type 1 diabetes.
Machine learning reveals PANoptosis as a potential reporter and prognostic revealer of tumour microenvironment in lung adenocarcinoma
Authors: Han Chunyan , Danzeng Quzhen , Li Liang , Bai Shanwang , Zheng Cuixia 
Published: October 2023

AbstractLung adenocarcinoma (LUAD), a prominent lung cancer subtype, has an underexplored relationship with PANoptosis, a recently discovered mode of tumour cell death. This study incorporated iron death, copper death, scorch death, necrotizing apoptosis and bisulfide death into a pan‐death gene set (PANoptosis) and conducted single‐cell analysis of scRNA‐seq data from 11 LUAD samples. Differentially expressed genes were identified, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed. Univariate COX regression and least absolute shrinkage and selection operator (LASSO) regression were used to screen PANoptosis key genes for constructing an LUAD risk model. The model’s prognostic performance was evaluated using survival curves, risk scores and validation in the Gene Expression Omnibus database. The study also explored the correlation between risk scores, tumour biological function, immunotherapy, drug sensitivity and immune infiltration. The SMS gene in the PANoptosis model was silenced in two LUAD cell lines for cellular validation. Single‐cell analysis revealed eight major cell types and several PANoptosis genes significantly associated with LUAD survival. The risk model demonstrated strong prognostic performance and association with immune infiltration, suggesting PANoptosis involvement in LUAD tumour immunity. Cellular validation further supported these findings. The PANoptosis key risk genes are believed to be closely related to the tumour microenvironment and immune regulation of LUAD, potentially providing valuable insights for early diagnosis and clinical treatment, and broader applications in other tumours and complex diseases.
Hepatic artery protection using a polyglycolic acid sheet during pancreaticoduodenectomy: A multicenter study
Authors: Lee Jun Suh , Yoon Young Chul , Hong Tae Ho , Yoon Yoo‐Seok , Park Sung Eun 
Published: October 2023

AbstractBackgroundPostpancreatectomy hemorrhage (PPH) is the most feared complication after pancreaticoduodenectomy (PD). The most common cause is erosion of the gastroduodenal artery stump. Preventive measures have been previously reported, but a consensus is lacking. The aim of this study was to analyze the preventive effect of reinforcing the hepatic artery using a polyglycolic acid (PGA) sheet during PD.MethodsA multicenter retrospective study was performed, collecting data from three tertiary hospitals in Korea. Patients receiving PD from January 2016 to December 2021 were included. The primary endpoint was rate of PPH from the hepatic artery. Arterial reinforcement (AR) was performed by wrapping the artery with Neoveil (Gunze Ltd) and applying fibrin glue. The perioperative data of patients who did not receive AR were compared with data of those who received AR.ResultsA total of 904 patients were analyzed. The rate of PPH from the hepatic artery was significantly lower in the AR group. (3.5% vs 0.7%, p = .002) In patients with CR‐POPF, the 90 day mortality rate of the AR group was less than half that of the non‐AR group (7.2% vs 3.5%, p = .455) Risk factor analysis showed CR‐POPF to be an independent risk factor for PPH. Arterial reinforcement was shown to be a strong protective factor for PPH (OR 0.20, 95% CI: 0.05–0.72, p = .014).ConclusionsAR of the hepatic artery using Neoveil and fibrin glue is a simple method that greatly reduces the rate of PPH after PD.
Timing of prophylactic antibiotics administration and suspected systemic infection after percutaneous biliary intervention
Authors: Im Hyunjae , Oh Seung‐Young , Lim Leerang , Lee Hannah , Kwon Jina , Ryu Ho Geol 
Published: October 2023

AbstractBackground/PurposeProphylactic antibiotics administration before percutaneous biliary intervention (PBI) is currently recommended, but the underlying evidence is mostly extrapolated from prophylactic antibiotics before surgery. The aim of this study was to evaluate the impact of prophylactic antibiotics administration timing on the incidence of suspected systemic infection after PBI.MethodsThe incidence of suspected systemic infection after PBI was compared in patients who received prophylactic antibiotics at four different time intervals between antibiotics administration and skin puncture for PBI. Suspected post‐intervention systemic infection was assessed according to predetermined clinical criteria.ResultsThere were 98 (21.6%) suspected systemic infections after 454 PBIs in 404 patients. There were significant differences among the four groups in the incidence of suspected systemic infection after the intervention (p = .020). Fever was the most common sign of suspected systemic infection. Administration of prophylactic antibiotics more than an hour before PBI was identified as an independent risk factor of suspected systemic infection after adjusting for other relevant factors (adjusted odds ratio = 10.54; 95% confidence interval, 1.40–78.86).ConclusionsThe incidence of suspected systemic infection after the PBI was significantly lower when prophylactic antibiotics were administered within an hour before the intervention.
Association between methicillin‐resistant Staphylococcus aureus nasal carriage and infection after pancreatic surgery
Authors: Jinushi Koichi , Shimizu Junzo , Yamashita Masafumi , Odagiri Kazuki , Yanagimoto Yoshitomo , Takeyama Hiroshi , Suzuki Yozo , Ikenaga Masakazu , Imamura Hiroshi , Dono Keizo 
Published: October 2023

AbstractBackgroundMethicillin‐resistant Staphylococcus aureus (MRSA) infections after pancreatectomy are relatively rare; however, they can be fatal when associated with pseudoaneurysms. For the past 12 years, we have been investigating nasal MRSA carriage by polymerase chain reaction testing, postoperatively in patients admitted to the intensive care units, to prevent nosocomial infections. Here, we investigated the relationship between MRSA nasal carriage and postoperative MRSA infection at the surgical site, following pancreatectomy.MethodsThis single‐center retrospective study analyzed 313 pancreatectomies (220 pancreaticoduodenectomies and 93 distal pancreatectomies), performed at our hospital between January 2011 and June 2022. The incidence of surgical site infection (SSI) and postoperative MRSA infection were compared between the nasal MRSA‐positive and nasal MRSA‐negative groups.ResultsMRSA nasal carriage was identified in 24 cases (7.6%), and the frequency of SSIs in the nasal MRSA‐positive and MRSA‐negative groups were 50% and 36.7%, respectively, with no significant difference (p = .273). However, the frequency of MRSA infection among the SSI cases was significantly higher in the nasal MRSA‐positive group (16.7%) than in the nasal MRSA‐negative group (1.7%) (p = .003).ConclusionIt should be noted that MRSA carriers have a significantly higher frequency of MRSA‐positive SSIs.
Benefit of living donor liver transplantation in graft survival for extremely high model for end‐stage liver disease score ≥35
Authors: Yun Sang Oh. , Kim Jongman , Rhu Jinsoo , Choi Gyu‐Seong , Joh Jae‐Won 
Published: October 2023

AbstractBackground and AimsLiving liver donation with high model for end‐stage liver disease (MELD) score was discouraged despite organ shortage. This study aimed to compare graft survival between living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) recipients with extremely high‐MELD (score of ≥35).MethodsBetween 2008 and 2018, 359 patients who underwent liver transplantation with a MELD score ≥35 were enrolled. We compared graft survival between LDLT and DDLT after propensity score matching (PSM) and performed subgroup analysis according to donor type.ResultsAfter PSM, there was no statistical difference in graft survival between the LDLT and DDLT groups (p = .466). Old age, acute on chronic liver failure, re‐transplantation, preoperative intensive care unit stay and red blood cell (RBC) transfusion during the operation were risk factors for graft failure (p = .046, .005, .032, .015 and .001, respectively). Biliary complications were more common in the LDLT group (p = .021), while viral infection, postoperative uncontrolled ascites, and postoperative hemodialysis were more common in the DDLT group (p = .002, .018, and .027, respectively). In the LDLT group, acute chronic liver failure, intraoperative RBC transfusion, and early postoperative complications were risk factors for graft failure (p = .007, <.001, and .001, respectively).ConclusionOur study showed that LDLT is not inferior to DDLT in graft survival if appropriate risk evaluation is performed in cases of extremely high‐MELD scores. This result will help overcome organ shortages in high‐MELD liver transplantation.
Humoral and cellular immune responses in fully vaccinated individuals with or without SARS‐CoV‐2 breakthrough infection: Results from the CoV‐ADAPT cohort
Authors: Hollstein Moritz M. , Dierks Sascha , Schön Michael P. , Bergmann Armin , Abratis Anna , Eidizadeh Abass , Kaltenbach Sarah , Schanz Julie , Groß Uwe , Leha Andreas , Kröger Andrea , Andag Reiner , Zautner Andreas E. , Fischer Andreas , Erpenbeck Luise , Schnelle Moritz 
Published: October 2023

AbstractDespite recent advances in prophylactic vaccination, SARS‐CoV‐2 infections continue to cause significant morbidity. A better understanding of immune response differences between vaccinated individuals with and without later SARS‐CoV‐2 breakthrough infection is urgently needed. CoV‐ADAPT is a prospective long‐term study comparing humoral (anti‐spike‐RBD‐IgG, neutralization capacity, avidity) and cellular (spike‐induced T‐cell interferon‐γ [IFN‐γ] release) immune responses in individuals vaccinated against SARS‐CoV‐2 at four different time points (three before and one after third vaccination). In this cohort study, 62 fully vaccinated individuals presented with SARS‐CoV‐2 breakthrough infections vs 151 without infection 3–7 months following third vaccination. Breakthrough infections significantly increased anti‐spike‐RBD‐IgG (p < 0.01), but not spike‐directed T‐cell IFN‐γ release (TC) or antibody avidity. Despite comparable surrogate neutralization indices, the functional neutralization capacity against SARS‐CoV‐2—assessed via a tissue culture‐based assay—was significantly higher following breakthrough vs no breakthrough infection. Anti‐spike‐RBD‐IgG and antibody avidity decreased with age (p < 0.01) and females showed higher anti‐spike‐RBD‐IgG (p < 0.01), and a tendency towards higher antibody avidity (p = 0.051). The association between humoral and cellular immune responses previously reported at various time points was lost in subjects after breakthrough infections (p = 0.807). Finally, a machine‐learning approach based on our large immunological dataset (a total of 49 variables) from different time points was unable to predict breakthrough infections (area under the curve: 0.55). In conclusion, distinct differences in humoral vs cellular immune responses in fully vaccinated individuals with or without breakthrough infection could be demonstrated. Breakthrough infections predominantly drive the humoral response without boosting the cellular component. Breakthrough infections could not be predicted based on immunological data, which indicates a superior role of environmental factors (e.g., virus exposure) in individualized risk assessment.
Association between missing teeth number and all‐cause and cardiovascular mortality: NHANES 1999–2004 and 2009–2014
Authors: Shen Ruming , Chen Shuaijie , Shen Jiayi , Lv Lingchun , Wei Tiemin 
Published: October 2023

AbstractBackgroundThe association between tooth loss and all‐cause and cardiovascular mortality requires further investigation.MethodsThis study included 17993 participants from the National Health and Nutrition Examination Surveys (NHANES) 1999–2004 and 2009–2014. Weighted multivariable Cox proportional hazard models were used to assess the association between tooth loss and all‐cause and cardiovascular mortality. Restricted cubic splines (RCS) were incorporated in the models to explore potential nonlinear relationships.ResultsOver a median follow‐up of 116 months, 2152 participants died, including 625 cardiovascular deaths. Compared to participants without missing teeth, participants with 11–19 missing teeth had the highest risk of all‐cause mortality (hazard ratio [HR] 1.89, 95% confidence interval [CI] 1.43–2.51), while participants with 6–10 missing teeth had the highest risk of cardiovascular mortality (HR 2.51, 95% CI 1.68–3.76). RCS analyses revealed nonlinear associations between number of missing teeth and all‐cause (p < 0.001) and cardiovascular (p = 0.001) mortality. With < 10 missing teeth, each additional missing tooth increased all‐cause and cardiovascular mortality by 6% (HR 1.06, 95% CI 1.03–1.09) and 9% (HR 1.09, 95% CI 1.03–1.15), respectively. However, when the number of missing teeth was ≥10, the risk of mortality did not continue to increase with more missing teeth. A significant interaction was found between tooth loss and age (p < 0.001 for both outcomes).ConclusionWe observed an inverted L‐shaped association between tooth loss and mortality, wherein risks increased with more missing teeth until 10, but did not continue increasing thereafter. The association was stronger in adults < 65 years old.
Ferroelectric liquid crystal array driven by a two‐layer electrode with a 1 × 1 μm pixel pitch for light modulation in electro‐holography
Authors: Aso Shintaro , Yamamoto Kisho , Aoshima Ken‐ichi , Higashida Ryo , Funabashi Nobuhiko , Shibasaki Junichi , Ishinabe Takahiro , Shibata Yosei , Fujikake Hideo , Machida Kenji 
Published: October 2023

AbstractWe clarified that a ferroelectric liquid crystal (FLC) has high resolution display capability as small as 1 × 1 μm pixel pitch using an FLC pixel array with a two‐layer electrode, which has a 1 × 1‐μm‐checkered apertured electrode and a plane electrode separated by an insulation layer. By applying +2 V to the apertured electrode and −10 V to the plane electrode in the two‐layer electrode and 0 V to the transparent common electrode, a checkered pattern was clearly observed, which indicates the successful individual pixel driving with a pixel pitch of 1 × 1 μm. When fabricating 1 × 2‐μm‐pitch rectangular FLC pixels, we elucidated that the liquid crystal alignment direction should be along the shorter side of the pixels to avoid asymmetric transmittance distribution in each pixel. Moreover, we successfully reconstructed a 3D holographic image using 10 × 10 k FLC pixel array with a pitch of 1 × 1 μm driven by the two‐layer electrode with hologram‐patterned apertures. We showed that FLC is a strong candidate material for realizing spatial light modulator with extremely small pixel pitches, which is essential for holographic displays with wide‐viewing‐zone angles.
A novel heterozygous deletion in ABCB4 gene in a Chinese family with intrahepatic cholestasis of pregnancy, neonatal hyperbilirubinemia, and cholelithiasis: Case reports and literature review
Authors: Zheng Yang , Rao Qunfang , Han Yiru , He Jianqin 
Published: October 2023

AbstractBackgroundABCB4 gene (OMIM *171060) variant is associated with a wide clinical spectrum of hepatobiliary diseases, including familial intrahepatic cholestasis of pregnancy (ICP), progressive familial intrahepatic cholestasis type 3 (PFIC3), and neonatal hyperbilirubinemia due to impaired protection of the bile duct. The majority of reported cases, however, were missense or nonsense variants, with few deletion variant findings in the Chinese population.MethodWe performed whole genome sequencing and confirmed it with Sanger sequencing of the proband infant and his families. Clinical courses and laboratory results were documented and collected from the proband infant and his mother. We also reviewed other published cases related to genetic variants in ABCB4 in the Chinese population.ResultsA 26‐year‐old Chinese female (II.2) who had recurrent intrahepatic cholestasis of pregnancy and her 49‐day‐old son (III.4) who had hyperbilirubinemia, both presented with extremely elevated total bile acid, cholestatic dominant pattern liver function abnormalities. They were able to stay relatively stable with mild pruritus on ursodeoxycholic acid treatment. After ruling out other possibilities, genetic sequencing revealed a diagnosis of heterozygous deletion variant NM_018849.3:c.1452_1454del (NP_061337.1:p.Thr485del) in ABCB4, which was not reported before, in the symptomatic mother (II.2), index patient (III.4), and the symptomatic grandmother (I.2). This variant resulted in clinical spectrums of ICP, neonatal hyperbilirubinemia, and cholelithiasis in our pedigree.ConclusionWe reported a novel heterozygous deletion variant of the ABCB4 gene in a Chinese family, as well as a literature review of ABCB4‐related disorders. We aim to facilitate healthcare professionals to better understand genetic factors as an uncommon cause of hepatobiliary diseases, as well as improve therapeutic strategies in challenging clinical situations such as pregnancy and neonatal care.
HyperSLICE: HyperBand optimized spiral for low‐latency interactive cardiac examination
Authors: Jaubert Olivier , Montalt‐Tordera Javier , Knight Daniel , Arridge Simon , Steeden Jennifer , Muthurangu Vivek 
Published: October 2023

AbstractPurposeInteractive cardiac MRI is used for fast scan planning and MR‐guided interventions. However, the requirement for real‐time acquisition and near‐real‐time visualization constrains the achievable spatio‐temporal resolution. This study aims to improve interactive imaging resolution through optimization of undersampled spiral sampling and leveraging of deep learning for low‐latency reconstruction (deep artifact suppression).MethodsA variable density spiral trajectory was parametrized and optimized via HyperBand to provide the best candidate trajectory for rapid deep artifact suppression. Training data consisted of 692 breath‐held CINEs. The developed interactive sequence was tested in simulations and prospectively in 13 subjects (10 for image evaluation, 2 during catheterization, 1 during exercise). In the prospective study, the optimized framework—HyperSLICE— was compared with conventional Cartesian real‐time and breath‐hold CINE imaging in terms quantitative and qualitative image metrics. Statistical differences were tested using Friedman chi‐squared tests with post hoc Nemenyi test (p < 0.05).ResultsIn simulations the normalized RMS error, peak SNR, structural similarity, and Laplacian energy were all statistically significantly higher using optimized spiral compared to radial and uniform spiral sampling, particularly after scan plan changes (structural similarity: 0.71 vs. 0.45 and 0.43). Prospectively, HyperSLICE enabled a higher spatial and temporal resolution than conventional Cartesian real‐time imaging. The pipeline was demonstrated in patients during catheter pull back, showing sufficiently fast reconstruction for interactive imaging.ConclusionHyperSLICE enables high spatial and temporal resolution interactive imaging. Optimizing the spiral sampling enabled better overall image quality and superior handling of image transitions compared with radial and uniform spiral trajectories.