bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of environmental enrichment on voluntary physical activity and muscle mass gain in growing rats
Authors: Sudo Mizuki , Kano Yutaka , Ando Soichi 
Published: September 2023

Introduction: Environmental enrichment (EE) for rodents involves housing conditions that facilitate enhanced sensory, cognitive, and motor stimulation relative to standard housing conditions. A recent study suggested that EE induces muscle hypertrophy. However, it remains unclear whether muscle hypertrophy in EE is associated with voluntary physical activity, and the characteristics of muscle adaptation to EE remain unclarified. Therefore, this study investigated whether muscle adaptation to EE is associated with voluntary physical activity, and assessed the changes in the muscle fiber-type distribution and fiber-type-specific cross-sectional area in response to EE.Methods: Wistar rats (6 weeks of age) were randomly assigned to either the standard environment group (n = 10) or the EE group (n = 10). The voluntary physical activity of rats housed in EE conditions was measured using a recently developed three-axis accelerometer. After exposure to the standard or enriched environment for 30 days, the tibialis anterior, extensor digitorum longus, soleus, plantaris, and gastrocnemius muscles were removed and weighed. Immunohistochemistry analysis was performed on the surface (anterior) and deep (posterior) areas of the tibialis anterior and soleus muscles.Results and discussion: The EE group showed increased voluntary physical activity during the dark period compared with the standard environment group (p = 0.005). EE induced muscle mass gain in the soleus muscle (p = 0.002) and increased the slow-twitch muscle fiber cross-sectional area of the soleus muscle (p = 0.025). EE also increased the distribution of high-oxidative type IIa fibers of the surface area (p = 0.001) and type I fibers of the deep area (p = 0.037) of the tibialis anterior muscle. These findings suggest that EE is an effective approach to induce slow-twitch muscle fiber hypertrophy through increased daily voluntary physical activity.
Cardioautonomic lability assessed by heart rate variability changes in Royal Canadian Mounted Police cadets during the cadet training program
Authors: Teckchandani Taylor A. , Neary J. Patrick , Andrews Katie L. , Maguire Kirby Q. , Jamshidi Laleh , Nisbet Jolan , Shields Robyn E. , Afifi Tracie O. , Sauer-Zavala Shannon , Lix Lisa M. , Krakauer Rachel L. , Asmundson Gordon J. G. , Krätzig Gregory P. , Carleton R. Nicholas 
Published: September 2023

ObjectiveThe current study examined variations in cardioautonomic lability during the Royal Canadian Mounted Police (RCMP) Cadet Training Program (CTP) between cadets starting their training who did or did not screen positive for one or more mental health disorders (i.e., posttraumatic stress disorder [PTSD], major depressive disorder [MDD], social anxiety disorder [SAD], generalized anxiety disorder [GAD], panic disorder [PD], alcohol use disorder [AUD]).MethodsElectrocardiogram (ECG) signals integrated into Hexoskin garments were used to record ECG and heart rate Over the 26-week CTP. There were 31 heart rate variability (HRV) parameters calculated using Kubios Premium HRV analysis software. Mann–Whitney U-tests were used to perform groupwise comparisons of participant raw values and HRV during the CTP.ResultsA total of 157 cadets (79% male) were screened for any mental disorder using self-report surveys and then grouped by positive and negative screening. Analyses indicated a statistically significant (p &lt; 0.05) decrease in low frequency (LF): High Frequency (HF) variability during CTP, but only for cadets who endorsed clinically significant anxiety symptoms on the GAD-7 at the start of their training. There were no other statistically significant groupwise differences.ConclusionThe results indicate the participants have excellent cardiac health overall and suggest potentially important differences between groups, such that cadets who endorsed clinically significant anxiety symptoms on the GAD-7 showed less variability in the LF:HF ratio over the course of the CTP. The relatively lower variability suggests decreased parasympathetic tone in those without clinically significant anxiety symptoms. The results also have important implications for future investigations of cardioautonomic dysfunction and chronic hypothalamic pituitary adrenal (HPA) axis deviations in policing populations with anxiety disorders; specifically, cardioautonomic inflexibility related to cardiovascular morbidity and mortality. In any case, the current results provide an important baseline for future cardiac research with cadets and serving officers.
When guilt works: a comprehensive meta-analysis of guilt appeals
Authors: Peng Wei , Huang Qian , Mao Bingjing , Lun Di , Malova Ekaterina , Simmons Jazmyne V. , Carcioppolo Nick 
Published: September 2023

IntroductionGuilt appeals are widely used as a persuasive approach in various areas of practice. However, the strength and direction of the persuasive effects of guilt appeals are mixed, which could be influenced by theoretical and methodological factors.MethodThe present study is a comprehensive meta-analysis of 26 studies using a random-effects model to assess the persuasive effects of guilt appeals. In total, 127 effect sizes from seven types of persuasive outcomes (i.e., guilt, attitude, behavior, behavioral intention, non-guilt emotions, motivation, and cognition) were calculated based on 7,512 participants.ResultsThe analysis showed a small effect size of guilt appeals [g= 0.19, 95% CI (0.10, 0.28)]. The effect of guilt appeals was moderated by the theoretical factors related to appraisal and coping of guilt arousal, including attributed responsibility, controllability and stability of the causal factors, the proximity of perceiver-victim relationship, recommendation of reparative behaviors, and different outcome types. The effect was also associated with methods used in different studies.DiscussionOverall, the findings demonstrated the persuasive effects of guilt appeals, but theoretical and methodological factors should be considered in the design and testing of guilt appeals. We also discussed the practical implications of the findings.
Study protocol: implementing and evaluating a trauma-informed model of care in residential youth treatment for substance use disorders
Authors: Walter Zoe C. , Carlyle Molly , Kerswell Nick , Mefodeva Valeriya , Nixon Reg D. V. , Cobham Vanessa E. , Hides Leanne 
Published: September 2023

IntroductionComorbidity between Substance Use Disorders and trauma/post-traumatic stress disorder (PTSD) is common, particularly within residential treatment services. Comorbidity is associated with poorer treatment retention and treatment outcomes. Integrated treatment approaches are increasingly recommended but are still under examined in residential treatment services. This study will implement and evaluate a novel model of trauma-informed care (TIC) in a youth (18–35 years) residential substance use treatment service.Methods and analysisA single-armed, phase 1 implementation trial will be conducted in one residential treatment service. The model, co-developed with staff, incorporates: (i) workforce development in TIC through staff training and clinical supervision; adaptions to the service (ii) policies, procedures, and physical settings and (iii) treatment program adaptions (in delivery style and content) to be more trauma-informed; (iv) client screening and feedback for trauma and PTSD at service entry; and (v) the provision of support, referral and/or trauma-focused therapy to those with PTSD. Service outcomes will include adherence to the TIC model and client treatment completion. Client substance use and mental health measures will be collected at service entry, and 1-, 3-, 6- and 12-months follow up. Staff outcomes, including workplace satisfaction, burnout, and fatigue, as well as perceptions and confidence in delivering TIC will be collected at baseline, and at 3-, 6-, 12- and 18-months following training in the model. The sustainability of the delivery of the TIC model of care will be evaluated for 12 months using service and staff outcomes.Ethics and disseminationThe study has received ethical approval by the University of Queensland (Approval number: 2020000949). The results will be disseminated through publication in a peer-reviewed scientific journal, presentations at scientific conferences, and distributed via a report and presentations to the partner organization.Clinical trial registration: ACTRN12621000492853.
Impact of COVID-19 on the treatment of depressive patients in Germany–a gap in care for the mentally ill?
Authors: Aichholzer Mareike , Schiweck Carmen , Uckermark Carmen , Hamzehloiya Tirage , Reif-Leonhard Christine , Golbach Rejane , Reif Andreas , Edwin Thanarajah Sharmili 
Published: September 2023

BackgroundThe COVID-19 pandemic led to a higher incidence of depression and a worsening of psychiatric conditions, while pre-existing constraints of the healthcare system and safety regulations limited psychiatric care.AimsWe investigated the impact of the pandemic on the clinical care of patients with a single episode (SE-MDD) or major depressive disorder (MDD) in Germany.MethodsNationwide inpatient data were extracted from the German Institute for Hospital Remuneration System for 2020 and 2021 (depression data) and the Robert Koch Institute (COVID-19 incidence). Changes in inpatients were tested with linear regression models. Local cases of depression in our department compared to 2019 were explored with one-way ANOVA and Dunnett's test.ResultsAcross Germany, the inpatient numbers with both SE-MDD and MDD declined by more than 50% during three out of four COVID-19 waves. Higher COVID-19 incidence correlated with decreased inpatient numbers. In our department, fewer MDD inpatients were treated in 2020 (adj. p &lt; 0.001) and 2021 (adj. p &lt; 0.001) compared to 2019, while the number of SE-MDD inpatients remained stable. During this period fewer elective and more emergency inpatients were admitted. In parallel, MDD outpatient admissions increased in 2021 compared to 2019 (adj. p = 0.002) and 2020 (adj. p = 0.003).ConclusionDuring high COVID-19 infection rates, MDD patients received less inpatient care, which might cause poor outcomes in the near future. These data highlight the necessity for improved infrastructure in the in- and outpatient domains to facilitate accessibility to adequate care.
Interrater and intra-rater reliability of the VERA-2R tool
Authors: Duits Nils , Kempes Maaike 
Published: September 2023

IntroductionThe Violent Extremism Risk Assessment - Version 2 Revised (VERA-2R) is an evidence-based structured professional judgement (SPJ) tool for ideologically motivated violence. Use of the tool can help professionals in risk assessment and risk management of suspected and convicted terrorists and violent extremists at different stages within the criminal process. It is important that the tool leads to reliable and valid risk assessments.MethodsThe present study aimed to establish the reliability of the VERA-2R, focusing on the interrater- and intrarater reliability. Trained researchers assessed the interrater- and intrarater reliability, respectively in 30 and 33 cases of Dutch convicted terrorist offenders, on the basis of extensive judicial files.ResultsIn general, the average amount of agreement on the indicators and structured risk judgements can be classified as good to excellent, for both the interrater- and intra-rater reliability. However, six indicators were found to have low reliability. Above clarifying the reliability of the VERA-2R, this study also showed how the interrater- and intrarater reliability of a SPJ tool can be investigated with trained assessors based on judicial files. This can be of added value, because existing reliability studies often use case vignettes, have a small sample size and/or do not include a stringent training program.DiscussionWith this research, we can make more substantiated recommendations on how the VERA-2R can be improved. This could lead to more accurate risk assessments and risk management strategies. However, in order to develop a more reliable and valid VERA-2R instrument, the remaining psychometric properties must also be investigated and published. That will be discussed in a future article.
Remotely supervised at-home delivery of taVNS for autism spectrum disorder: feasibility and initial efficacy
Authors: Black Benjamin , Hunter Samantha , Cottrell Hannah , Dar Roee , Takahashi Nicole , Ferguson Bradley J. , Valter Yishai , Porges Eric , Datta Abhishek , Beversdorf David Q. 
Published: September 2023

BackgroundTranscutaneous auricular vagus nerve stimulation (taVNS) has potential clinical application for autism spectrum disorder (ASD). At-home sessions are necessary to allow delivery of repeated sessions, and remove burden on patients for daily visits, and reduce costs of clinic delivery. Our objective was to validate a protocol for remote supervised administration for home delivery of taVNS using specially designed equipment and platform.MethodsAn open-label design was followed involving administration by caretakers to 12 patients with ASD (ages:7–16). Daily 1-h sessions over 2 weeks were administered under remote supervision. The primary outcome was feasibility, which was assessed by completion rate, stimulation tolerability, and confirmation of programmed stimulation delivery. The secondary measures were initial efficacy assessed by Childhood Anxiety Sensitivity Index-Revised (CASI-R), Parent Rated Anxiety Scale for Youth with ASD (PRAS-ASD), and Clinician Global Impression (CGI) scales. Sleep measures were also tracked using Cleveland Adolescent Sleep Questionnaire (CASQ).ResultsAcross 132 sessions, we obtained an 88.5% completion rate. A total of 22 expected adverse events were reported with headache being the most common followed by transient pain, itchiness, and stinging at the electrode site. One subject dropped out of the study unrelated to the stimulation or the study. Average scores of anxiety (CASI-R, PRAS-ASD, and CGI) and sleepiness (CASQ) were all improved at the 2 week time point. While not powered to determine efficacy, benefits were suggested in this open label pilot.ConclusionRemotely supervised, proxy-administered, at-home delivery of taVNS is feasible in patients with ASD. Initial efficacy supports pursuing larger scale trials.
Severe chronic abuse of zolpidem for over 10 years: a case report and review of similar cases
Authors: Moshfeghinia Reza , Jazi Kimia , Kabaranzadghadim Shabnam , Malekpour Mahdi , Oji Bahare 
Published: September 2023

BackgroundInsomnia is a major health issue, and zolpidem is an effective treatment for insomnia. However, high doses of zolpidem can cause dependence, abuse, and withdrawal symptoms, questioning its advantages.Case presentationA 39-year-old woman who has been divorced and unemployed for 2 years was referred to an addiction treatment center with a chief complaint of “seizure-like withdrawal symptoms after consuming high doses of zolpidem (up to 6,000 mg per day) for a decade.” These symptoms were in the form of body tremors, nystagmus, stress, anxiety, hot flashes, and sweaty palms. She has been undergoing detoxification by clonazepam for almost 2 months. Except for the first few days, she did not have any withdrawal symptoms, and her insomnia caused by zolpidem has improved.ConclusionChronic abuse of zolpidem can cause dependence, withdrawal symptoms, and abuse. High doses can lead to extreme cravings and dependence. Physicians must manage the withdrawal process.
Potential impacts of Russo-Ukraine conflict and its psychological consequences among Ukrainian adults: the post-COVID-19 era
Authors: Khan Ahsan Riaz , Altalbe Ali 
Published: September 2023

BackgroundSince February 2022, the nation of Ukraine has become entangled in an escalating conflict that erupted after coronavirus outbreak fostering a situation of indeterminacy and precariousness, which adversely affected several facets, especially psychological well-being. However, there is a lack of empirical evidence on the psychological well-being of Ukrainians during the Russo-Ukraine war, as well as their coping strategies in response to the war’s repercussions. Consequently, this investigation endeavors to explore the prevalence of symptoms associated with depression, anxiety, stress, and insomnia and to correlate these symptoms with Ukrainians’ effective coping mechanisms during the ongoing war.MethodsAn online survey was administered in Ukraine from June to August 2022 due to the ongoing Russo-Ukraine conflict. The survey employed a quota sampling technique, targeting 2,664 individuals (≥18 years). Out of the total sample, 1,833 valid responses were obtained, yielding a response rate of 68. 81%. Depression, anxiety, and stress were measured using the depression, anxiety, and stress scale-21 (DASS-21), while the Pittsburgh sleep quality index (PSQI) was utilized to evaluate insomnia symptoms. In addition, Brief-COPE was adopted to evaluate the coping mechanisms of the selected study participants.ResultsOf 1,833 Ukrainian adults, 60.5% had symptoms of stress; 62.4% of them reported symptoms of anxiety; and 58.2% reported symptoms of depression. Symptom criteria for insomnia were found in about 21.8% of the study sample. The factors of sex, living area, area occupied by Russian forces, and having older adults and children in the house were statistically significant with symptoms of depression, anxiety, stress, and insomnia. The productive coping strategies of self-distraction, using instrumental support, planning, and behavioral disengagement, were observed as statistically significant with four psychological constructs.ConclusionThe study outcomes highlight a substantial prevalence of symptoms related to depression, anxiety, stress, and insomnia attributed to the accumulated consequences of ongoing conflict and the COVID-19 outbreak. The aforementioned findings emphasize the imperative of providing healthcare services and facilitating effective coping strategies among Ukrainians amid the ongoing war.
Application of virtual and mixed reality for 3D visualization in intracranial aneurysm surgery planning: a systematic review
Authors: Colombo Elisa , Lutters Bart , Kos Tessa , van Doormaal Tristan 
Published: September 2023

BackgroundPrecise preoperative anatomical visualization and understanding of an intracranial aneurysm (IA) are fundamental for surgical planning and increased intraoperative confidence. Application of virtual reality (VR) and mixed reality (MR), thus three-dimensional (3D) visualization of IAs could be significant in surgical planning. Authors provide an up-to-date overview of VR and MR applied to IA surgery, with specific focus on tailoring of the surgical treatment.MethodsA systematic analysis of the literature was performed in accordance with the PRISMA guidelines. Pubmed, and Embase were searched to identify studies reporting use of MR and VR 3D visualization in IA surgery during the last 25 years. Type and number of IAs, category of input scan, visualization techniques (screen, glasses or head set), inclusion of haptic feedback, tested population (residents, fellows, attending neurosurgeons), and aim of the study (surgical planning/rehearsal, neurosurgical training, methodological validation) were noted.ResultsTwenty-eight studies were included. Eighteen studies (64.3%) applied VR, and 10 (35.7%) used MR. A positive impact on surgical planning was documented by 19 studies (67.9%): 17 studies (60.7%) chose the tailoring of the surgical approach as primary outcome of the analysis. A more precise anatomical visualization and understanding with VR and MR was endorsed by all included studies (100%).ConclusionApplication of VR and MR to perioperative 3D visualization of IAs allowed an improved understanding of the patient-specific anatomy and surgical preparation. This review describes a tendency to utilize mostly VR-platforms, with the primary goals of a more accurate anatomical understanding, surgical planning and rehearsal.
Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions
Authors: Steblaj Barbara , Galli Jasmin , Torgerson Paul , Kutter Annette 
Published: September 2023

IntroductionThe aim of this retrospective study was to determine whether there is an association between leukoreduction of packed red blood cell (pRBC) units and reduction of clinically observed transfusion reactions (TR), particularly febrile non-haemolytic transfusion reactions (FNHTR), and better outcomes in dogs. Secondary aims were to evaluate the effects of other factors suspected to influence transfusion reaction frequency or survival, including crossmatching, use of immunosuppressive drugs, and age and number of the blood products being administered.Materials and methodsMedical data on dogs transfused with leukocyte-reduced (LR) and non-leukocyte-reduced (N-LR) pRBC units at the Animal Hospital Zürich, University of Zürich, Switzerland between January 1, 2007, and December 17, 2018 were searched. Before 2014, only N-LR blood were transfused. After 2014, both LR and N-LR blood were available.ResultsA total of 339 canine patients were transfused with 413 pRBC units; 30.5% (126/413) were LR units and 69.5% (287/413) were N-LR. Data collected from medical records was analyzed using univariate and multivariate logistic regression. In the present study, TR occurred in 19.8% of pRBC units (25/126) with LR and in 17.7% (51/287) of pRBC with N-LR; p &gt; 0.05. FNHTR occurred in 6.3% of pRBC units (8/126) with LR and in 4.5% (13/287) of those with N-LR; p &gt; 0.05. There was no correlation between the occurrence of TR and discharge from hospital (p &gt; 0.05). Crossmatching, immunosuppressive therapy, and age of the blood product were not associated with the frequency of TR; p &gt; 0.05 for all. The duration of survival days was not related to the number of transfusions dogs received.DiscussionIn the present study, the leukocyte-depletion of transfused pRBC units was not associated with fewer TR nor to fewer FNHTR compared to N-LR units. Discharge of dogs from hospital was not dependent on the occurrence of TR.
MEMBANGUN SERVER VOIP DENGAN ASTERISK DI LINUX BESERTA ADMINISTRASI USER BERBASIS WEBSITE
Authors: Setyowibowo Sigit , . Syahminan 
Published: September 2023

The development of computer network allows for rapid pass voice traffic over computer networks or common called VoIP (Voice Over Internet Protocol). Voice over Internet Protocol (VoIP) is a technology capable of passing voice traffic and video or even a form of data packets over a computer network based on IP (Internet protocol). Major emphasis of VoIP (Voice Over Internet Protocol) is the cost. With two locations that are connected to the internet or network then the conversation becomes very low cost even close to free (Rp0, 00 -). This system is designed using an asterisk on fedora 7 -1.6.0.13 Keywords : VoIP (Voice Over Internet Protocol)
DESAIN SISTEM WEB PERSONAL SEBAGAI SARANA PENYAMPAIAN INFORMASI BAGI SIVITAS AKADEMIKA STMIK PPKIA PRADNYA PARAMITA
Authors: Marisa Fitri 
Published: September 2023

Personal web made with the development of cyber campus, with the understanding that submission of an online campus information, allowing students to find out what information they needed around campus. It is thus necessary to build Personal Web systems that can be applied for STMIK Pradnya Paramita to provide information from the academic campus. Benefits that can be felt for academicians are able to access academic information, finance, as well as originating from outside the tehubung with the campus. In addition, students and lecturers can set personal web pages in accordance with the actualization of his web site STMIK Pradnya Paramita campus. Keywords : Web Personal, STMIK Pradnya Paramita, cyber campus, civitas academica