bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transforming health-care service through consumer co-creation: directions for service design
Authors: Carlini Joan , Muir Rachel , McLaren-Kennedy Annette , Grealish Laurie 
Published: November 2023

Purpose
The increasing financial burden and complexity of health-care services, exacerbated by factors such as an ageing population and the rise of chronic conditions, necessitate comprehensive and integrated care approaches. While co-created service design has proven valuable in transforming some service industries, its application to the health-care industry is not well understood. This study aims to examine how health consumers are involved in health-care service co-creation.

Design/methodology/approach
The study searched 11 electronic databases for peer-reviewed articles published between 2010 and 2019. Additionally, hand searches of reference lists from included studies, Google© citation searches and searches for grey literature were conducted. The Whittemore and Knafl integrative framework guided the systematic review, and Callahan’s 6 Ws framework was used to extract data from the included articles, facilitating comparisons.

Findings
The authors identified 21 articles, mainly from the UK, North America and Australia. Despite the need for more research, findings reveal limited and geographically narrow empirical studies with restricted theory and method applications. From these findings, the authors constructed a conceptual model to enhance nuanced understanding.

Originality/value
This study offers four contributions. First, it introduces the Health Service Design Transformation Model for Comprehensive Consumer Co-Creation, illustrating health consumers’ multifaceted roles in shaping services. Second, consumer vulnerabilities in co-creating services are identified, linked to diverse consumer groups, power dynamics and decision complexity. Third, this study suggests broadening participant inclusion may enhance consumer-centricity, inclusivity and innovation in service design. Finally, the research agenda explores consumer experiences, organizational dynamics, value outcomes and co-creation theory for health-care service advancement.
The downside of phones at work: exploring negative relationships between leader phubbing and follower engagement/performance
Authors: Bracht Eva Maria , Hernandez Bark Alina S. , She Zhuolin , Van Dick Rolf , Junker Nina Mareen 
Published: November 2023

PurposeThe aim of this paper is gaining a deeper understanding of potential negative effects of (smart)phone use at work. The authors do so by exploring mediating mechanisms and boundary conditions between leader phubbing, leaders snubbing their followers by glancing at their phones during an interaction; and follower (1) work engagement and (2) performance.Design/methodology/approachThe authors conducted a survey-based time-lagged, multi-source and team-based study of leaders (N = 93) and their followers (N = 454).FindingsResults of this paper showed that leader phubbing negatively relates to follower (1) work engagement and (2) performance through less perceived leader support. Contradictory to the hypothesis, the relationship between leader phubbing and perceived leader support was negative for male leaders only.Originality/valueThe authors contribute to existing research by (1) adding perceived support as an important mediator between leader phubbing and work engagement/performance, (2) exploring the effects of leader gender and (3) adding information on the cultural robustness of the leader phubbing phenomenon by testing it outside the Western work context.
Workaholism and quality of work-life: a psychosocial pathway to brain-drain syndrome
Authors: Akinwale Olusegun Emmanuel , Kuye Owolabi Lateef , Akinwale Olayombo Elizabeth 
Published: November 2023

PurposeThe cultural norm of compelling employees to work beyond the standard measure as a result of internal pressure from organisations is gaining popularity in the business environment today. This research is a pointer to a nuanced and dynamic understanding of workaholism, and this study aims to investigate factors that constitute an individual as a workaholic in the banking industry in Nigeria. This study aims to examine the influence of workaholism on the quality of work-life (QWL) of the workforce and how it led pockets of the workforce to migrate to an international workspace.Design/methodology/approachTo capture a good understanding of what describes an individual as a workaholic, and what influences the QWL among the workforce in the banking environment, this study utilised a longitudinal research design to survey bankers in corporate organisations in Nigeria. The study administered a battery of adapted scales to measure latent constructs of dimensions of workaholism and QWL on a random simple probability technique. The study surveyed 425 professional bankers in Nigeria's banking workspace. A structural equation model was used to analyse the data obtained from the banking workforce to establish the relationship that exists between the dimensions of workaholism and QWL.FindingsThe outcome of this study indicated an insightful one. The results of the study illustrated that long hours of work, workload, work pressure, financial challenges as well and the pursuit of career growth are determinants of workaholism in banking corporate business. The study illustrated that all the predictors of workaholism equally affect the QWL of the employees in Nigeria's banking industry.Originality/valueThe originality of this study is captured in the dynamics of the concept of workaholism which portends negative outcomes in the Nigerian business environment given the nature of banking business in Nigeria. The study elucidates that workaholism is not work engagement in Nigeria but the attitude of compulsion from the management of the organisations.
Performance management and open innovation: evidence from Brazilian startups
Authors: Frare Anderson Betti , Akroyd Chris 
Published: November 2023

PurposeThe purpose of this paper is to examine the effects of performance management (PM) practices on in-bound open innovation (OI) and out-bound OI. To do this, the authors examine the organizational effectiveness as well as the non-financial and financial performance of Brazilian startups that have had recent OI relationships with larger companies.Design/methodology/approachUsing data collected from 103 Brazilian startups, the hypotheses were tested via partial least squares–structural equation modeling (PLS-SEM). An additional analysis was performed using fuzzy-set qualitative comparative analysis (fsQCA).FindingsThe findings show that PM practices orchestrate in-bound OI and out-bound OI; however, only in-bound OI promotes organizational effectiveness in Brazilian startups. Organizational effectiveness results in good non-financial performance, which in turn improves financial performance. PM practices have an indirect effect on financial performance from the serial mediation of in-bound OI, organizational effectiveness and non-financial performance. Moreover, several combinations of conditions lead to high levels of organizational effectiveness, non-financial performance and financial performance.Originality/valueThis study provides new evidence and insights from an emerging market on the antecedents and consequences of startups' OI adoption.
Overlooked factor in the etiology of pruritus in hemodialysis patients: Ultrafiltration volume
Authors: Ozer Hakan , Ozturk Yasin , Yonet Fethi , Baloglu Ismail , Turkmen Kultigin , Selcuk Nedim Yılmaz , Tonbul Halil Zeki 
Published: November 2023

AbstractIntroductionThis study investigated the relationship between ultrafiltration (UF) volume and pruritus severity based on the idea that skin perfusion and inflammatory changes occur in dialysis patients with high UF volume.Materials and MethodsThis observational study included 392 patients. Patients filled out the Numerical Rating Scale, Verbal Rating Scale, and Visual Analogue Scale, showing the severity of pruritis. UF volumes in the last 12 sessions were recorded and averaged.ResultsThe rate of patients with pruritis was between 59.4% and 67.5% in the three scales. In three pruritis scales, the severity of pruritis, age, body mass index (BMI), UF volume, and UF volume/body weight ratio were positively correlated. UF volume/body weight ratio, age, and BMI were independent predictors of pruritis severity.ConclusionLimiting interdialytic weight gain may be an important treatment approach in pruritus control.
Do people feel they belong? Socio‐political factors shaping the place attachment of Hong Kong citizens
Authors: Lee Man Yee Karen , Wong Mathew Y. H. , Chan Anita Kit Wa , Chong Eric King‐man , Cheung Lewis T. O. 
Published: November 2023

AbstractHong Kong citizens’ sense of belonging has gone through a period of fluctuation during the period of rapid socio‐political and legal change since the outbreak of the Anti‐Extradition Law Amendment Bill Movement in 2019. This study explored how multiple dimensions of the place attachment of Hong Kong citizens have been shaped by factors associated with these changes. Six socio‐political variables were incorporated into the three dimensions of the person–process–place (PPP) framework. Based on a representative survey of the local population (n = 768), we found that political inclination and identity were significantly associated with the sense of place, with citizens identifying as Chinese and aligning with the pro‐establishment camp showing higher levels of place attachment. Mobility was negatively associated with place attachment, whereas the correlation between attachment and perceptions of the law and legal system was positive. The study has implications for Hong Kong’s current socio‐political and institutional environment and for emigration. It also demonstrates the wider applicability of the PPP framework for identifying and clarifying the various predictors of different dimensions of place attachment.
Gentiana macrophylla flavonoids from Tibetan medicine decreases circ_0059665 to alleviate the progression of non‐small cell lung cancer under hypoxia
Authors: Ma Mi , Ciren Dunzhu , Feng Mingke , Zhen Luo , Jin Guilin 
Published: November 2023

AbstractBackgroundGentiana macrophylla Pall. is a traditional Tibetan medicinal herb possessing antinociceptive and anti‐inflammatory activities. Circular RNAs (circRNAs) have been identified to be involved in the tumorigenesis of non‐small cell lung cancer (NSCLC). Here, this study focused on investigating the function and mechanism of Gentiana macrophylla flavonoids (GF) and circ_0059665 in NSCLC progression.MethodsThe contents of mRNA and protein were detected using qRT‐PCR and western blotting analysis. Cell proliferative and invasive abilities were evaluated by cell counting kit‐8, EdU, colony formation and transwell assays, respectively. M2 macrophage polarization was analyzed by flow cytometry.ResultsGF treatment suppressed NSCLC cell proliferation, invasion and M2 macrophage polarization under hypoxic conditions. Circ_0059665 was highly expressed in NSCLC tissues and cells. Its expression was increased under hypoxic conditions but was reduced following GF treatment. Furthermore, circ_0059665 overexpression reversed the anticancer effects of GF on NSCLC cells under hypoxic conditions. Mechanistically, circ_0059665 acted as a sponge for miR‐512‐5p to regulate NOVA2 expression. Hypoxia decreased miR‐512‐5p levels, and increased NOVA2 levels in NSCLC cells, while these tendencies were abolished after GF treatment. Circ_0059665 silencing inhibited NSCLC cell proliferation, invasion and M2 macrophage polarization in hypoxic environments, which were counteracted by NOVA2 overexpression. Moreover, NOVA2 upregulation reversed the suppressive effects of GF on NSCLC cells with hypoxia treatment. In addition, GF impeded NSCLC tumor growth in vivo via suppressing circ_0059665.ConclusionGF treatment in hypoxic environments suppressed NSCLC cell proliferation, invasion and M2 macrophage polarization via the circ_0059665/miR‐512‐5p/NOVA2 axis.
The association between frailty and ageing: Results from an observational study including 9497 elderly patients
Authors: Jensen Liva Thoft , Lundstrøm Lars , Kowark Ana , Coburn Mark , Steinmetz Jacob ,   for the POSE‐Study Group
Published: November 2023

AbstractBackgroundElderly surgical patients have a high risk of postoperative complications. However, patients exhibit considerable diversity in health and functional status; thus, identifying the fragile may be necessary when selecting surgical candidates. We aimed to compare the prevalence of frailty in patients ≥90 years with patients aged 80–89. Second, we assessed the association between frailty and all‐cause 30‐day mortality.MethodsWe performed a planned secondary analysis of the peri‐interventional outcome study in the elderly (POSE), including 9497 patients (≥80 years) undergoing any surgical and nonsurgical procedures in 177 European centres from October 2017 to December 2018. The primary outcome assessment included frailty as a binary variable, and data were analysed using Fisher's exact test/Chi‐squared test. The association between frailty and all‐cause 30‐day mortality was analysed using a multivariate logistic regression model adjusted for age, sex, surgical urgency, orthopaedic urgency, and surgical severity.ResultsIn total, 999 of 9497 (10.5%) patients were 90 years or above. Among patients ≥90 years, 274 (27.4%) were frail compared to 1062 (12.5%) of patients aged 80–89 (odds ratio (OR): 2.6; 95% CI 2.3–3.1). Frailty was associated with increased 30‐day mortality in both the unadjusted (crude OR 6.3; 5.1–7.7) and adjusted analysis (OR 4.5; 3.6–5.7). In the adjusted analysis, age ≥90 was not associated with 30‐day mortality.ConclusionWe found a high frequency of frailty in patients aged 90 years or above compared with patients aged 80–89. In addition, frailty was associated with an increased risk of 30‐day mortality. Surprisingly, age was not a significant risk factor in the adjusted mortality analysis.
Prenatal antidepressant exposure and the risk of decreased gestational age and lower birthweight: A polygenic score approach to investigate confounding by indication
Authors: Rommel Anna‐Sophie , Semark Birgitte Dige , Liu Xiaoqin , Madsen Kathrine Bang , Agerbo Esben , Munk‐Olsen Trine , Petersen Liselotte Vogdrup , Bergink Veerle 
Published: November 2023

AbstractIntroductionPrenatal antidepressant exposure has been associated with lower gestational age and birthweight. Yet, unmeasured residual confounding may inflate this association. We explored if maternal genetic liability for major depression explains part of the association of antidepressant use in pregnancy with lower gestational age and birthweight.Material and MethodsWe employed the maternal polygenic score (PGS) for major depression as a measure of genetic liability. We used generalised linear models to estimate the differences in gestational age and birthweight at each PGS quintile between children whose mothers continued antidepressant use during pregnancy (continuation group), children whose mothers discontinued antidepressant use during pregnancy (discontinuation group) and unexposed children.ResultsAfter adjusting for confounders, we found significant differences in birthweight between PGS quintiles in the continuation and unexposed group. Yet, this relationship was not linear. Furthermore, at the lowest and highest PGS quintiles, the continuation group had significantly reduced mean gestational ages (adjusted β ranges: 1.7–4.5 days, p < 0.001–0.008) and lower mean birthweights (adjusted β ranges: 58.6–165.4 g, p = 0.001–0.008) than the discontinuation and unexposed groups.ConclusionWe confirmed that antidepressant use in pregnancy was associated with small reductions in gestational age and birthweight but found that genetic liability for depression was not linearly associated with this risk. The causality of the observed associations could not be established due to the observational nature of the study. Residual confounding linked to the underlying disease was likely still present.
Workforce automation risks across race and gender in the United States
Authors: McManus Ian P. 
Published: November 2023

AbstractAlthough the effects of automation on the future of work have received considerable attention, little research has been conducted on the costs of this technological transformation for different populations of workers. This article makes an important contribution as one of the first to analyze the intersectional effects of workforce automation across race and gender in the United States. Multilevel survey data models are employed using two distinct measures of automation job displacement risk for over 1.4 million Americans across 385 occupations. This research demonstrates that the intersection of race and gender matters for individual automation risks. Education, age, disability, and nativity are also significant. These findings indicate that labor market outcomes of job automation will be based not only on differences in human capital but critically on socially constructed identities as well.
The use of intraperitoneal chemotherapy for advanced ovarian cancer – The experience of a tertiary referral centre
Authors: Foster Leon , Girgis Christina , Kirby Adrienne , Harnett Paul , Brand Alison 
Published: November 2023

BackgroundPlatinum‐based chemotherapy is the backbone of the medical management of ovarian cancer. The dose, route and timing of treatment are ongoing areas of debate. Intraperitoneal (IP) chemotherapy is an alternative delivery method treatment to the conventional intravenous (IV) route for patients with epithelial ovarian cancer, with efficacy supported by Level 1 evidence.AimsTo compare the outcomes and feasibility of IP to IV delivery of platinum‐based chemotherapy in patients with advanced epithelial ovarian cancer.Materials and MethodsIn a single institution, patients receiving adjuvant chemotherapy (IP and IV) for Stages III and IV epithelial ovarian cancer over the period January 2006–December 2018 were identified through a prospectively maintained database. All patients with an IP port inserted were included. A control group of patients treated with IV chemotherapy was created using criteria identified during the study and in the randomised trials that tested IP chemotherapy. Assessments were made for relapse‐free survival (RFS) and overall survival (OS) for each cohort.ResultsA total of 639 patients received adjuvant chemotherapy (73 IP and 566 IV) during the study period. Both the IP group and matched IV control group (65 patients) had a median RFS of 26 months. The median OS in the IP group was 63.9 months, and in the IV group was 57.2 months. At ten years, a significantly higher proportion of patients were alive in the IP group cohort (16% vs 3%, relative risk 5.5, 95% CI 1.29–24, P = 0.012). IP chemotherapy was well tolerated by our cohort. In the IP group, 73% had four or more IP cycles and 99% received six or more cycles of chemotherapy.ConclusionsOur cohort had a high rate of completion of IP chemotherapy with excellent rates of completion of six cycles of any treatment. The RFS and OS in the IP chemotherapy group were comparable to each other and reflected those in the published literature. A significantly higher proportion of patients in the IP cohort were alive at ten years than in the IV cohort.
Long‐term survival following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in Waikato, Aotearoa New Zealand: a 12‐year experience
Authors: Qin Rennie Xinrui , Lim Jia Hui , Ly Jasen , Fischer Jesse , Smith Nicholas , Karalus Mosese , Wu Linus , van Dalen Roelef , Lolohea Simione 
Published: November 2023

AbstractBackgroundsCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have improved survival for selected cases of peritoneal surface malignancy. In 2008, a CRS/HIPEC service was first established in Aotearoa New Zealand (AoNZ) at Waikato and Braemar Hospitals in the Waikato region.MethodsThis is a retrospective review of a prospectively maintained database of all patients undergoing CRS/HIPEC from 1 January 2008 to 1 November 2020 at Waikato and Braemar Hospitals. We analysed long‐term survival and predictors of survival for each tumour type.Results240 procedures were performed for 221 patients, including 22 re‐do procedures. Cases had a median peritoneal cancer index of 16. Complete cytoreduction (CC0‐1) was achieved in 196 cases (81.7%). All complete cytoreduction cases received HIPEC. There were 152 pseudomyxoma peritonei (PMP), 39 colorectal cancers (CRC), 29 appendiceal cancers, eight ovarian cancers, six peritoneal mesotheliomas, and six other cancers. The 5‐year overall survival (OS) for PMP with acellular mucin, low‐grade mucinous carcinoma peritonei, and high‐grade mucinous carcinoma peritonei with or without signet cells were 91.6%, 80.5%, and 72.2%, respectively. 2‐ and 5‐year OS in CRC were 56.7% and 40.4%. The achievement of complete cytoreduction improved the 5‐year OS to 87.9% across all PMP and 45.1% in colorectal cancer. Incomplete cytoreduction predicted worse survival in appendiceal PMP. In colorectal cancer, worse survival was predicted in those who had incomplete cytoreduction, liver metastasis, and presentation with obstruction and perforation.ConclusionFavourable long‐term outcomes following CRS/HIPEC for peritoneal surface malignancy have been achieved in AoNZ through the Waikato peritonectomy service.
Population pharmacokinetic analysis of doravirine in real‐world people with HIV
Authors: Thoueille Paul , Delarive Luc , Cavassini Matthias , Buclin Thierry , Decosterd Laurent A. , Marzolini Catia , Girardin François R. , Guidi Monia ,   The Swiss HIV Cohort Study
Published: November 2023

AimsThe pharmacokinetics of doravirine has been studied in clinical trials but not in real‐world settings. Our study aims to characterize and identify factors influencing doravirine (a CYP3A4 substrate) pharmacokinetics in real‐world people with HIV (PWH).MethodsA total of 174 doravirine concentrations measured in 146 PWH followed up in the therapeutic drug monitoring (TDM) program at the University Hospital of Lausanne (Switzerland) between 2019 and 2023 were included in the analysis. Demographic data, clinical information and comedications were recorded during the routine SHCS visits (every 3–6 months). Population pharmacokinetic analysis and Monte Carlo simulations to investigate the clinical significance of the covariates retained in the final model were performed using NONMEM.ResultsA one‐compartment model with first‐order absorption and linear elimination best described doravirine pharmacokinetics. Potent CYP3A4 inhibitors and, to a lesser extent age, were the only tested covariates to significantly impact doravirine clearance (CL). Potent CYP3A4 inhibitors reduced CL by 50%, and a 30% decrease in CL was observed in an 80‐year‐old compared with a 55‐year‐old PWH. The effect of potent CYP3A4 inhibitors was prominent, explaining 59% of between‐subject variability in CL. Model‐based simulations predicted 2.8‐fold and 1.6‐fold increases in median steady‐state trough and maximum doravirine concentrations, respectively, when a potent CYP3A4 inhibitor was co‐administered.ConclusionsOur findings show that potent CYP3A4 inhibitors and age influence doravirine pharmacokinetics. However, given the good tolerability of doravirine, dosing adjustment of doravirine is probably not mandatory in those situations. TDM remains useful essentially in specific clinical situations, such as hepatic impairment, suspected nonadherence or pregnancy.