bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Composite of Polyether Ether Ketone and Silica‐Coated Copper Particles for Creating Tailored Conductive Tracks via Laser Printing
Authors: Schnettger Alexander , Holländer Ulrich , Maier Hans J. 
Published: October 2023

AbstractConventional substrates for optoelectronic systems include inorganic or organic carrier materials; however, these systems are typically subjected to environmentally harmful multistep processes to prepare printed circuit boards. To mitigate these issues, the present article reports a polyether ether ketone (PEEK)‐based composite densely filled with copper microparticles, prepared using a simple, cost‐effective, and sustainable synthesis method. The material exhibits high thermal conductivity but is electrically nonconductive prior to undergoing laser treatment. To prevent the composite from exhibiting electrical conductivity, the copper particles are coated with a thin silica layer through a sol–gel reaction. The thermal stability of PEEK and the Cu–PEEK composites with Cu contents of up to 70 vol%, which are prepared via heat melding, is investigated by thermogravimetric analysis, differential scanning calorimetry, and Fourier‐transform infrared spectroscopy to clarify the manner in which copper affects the chemical structure of the polymer. The developed composite exhibits a significantly higher thermal conductivity than that of the unfilled PEEK polymer. This paper also describes the effects of laser treatment on the surface morphology. Overall, this study suggests that conductive tracks with low electrical resistance can be created on electrically insulating substrates with high thermal conductivity.
Crosslinked copolymers with degradable oligo(lactide) branches
Authors: Sandner Barbara , Steurich Simone , Wartewig Siegfried 
Published: October 2023

AbstractMethods for preparation of oligo(lactone) macromonomers end‐capped with methacrylate groups are summarized. The conversion of C=C double bonds during the crosslinking copolymerization of the macromonomers has been studied by means of Laser Raman spectroscopy at room temperature. Glass transition, mechanical properties and the degradation rate of composite materials prepared by copolymerization in the presence of hydroxylapatite may systematically be influenced both by the type of lactone monomer, e.g. D,L‐ or L,L‐dilactide, diglycolide, and the comonomer, e.g. 2‐hydroxyethyl methacrylate, tetrahydro‐furfuryl methacrylate, tri(ethylene glycol) dimethacrylate.The composites should be useful as bone implant materials with lower polymerization exotherm and better biocompatibility than conventional materials based on methyl methacrylate.
A Randomized Phase 3 Study Comparing P2B001 to its Components (Low‐Dose Extended‐Release Rasagiline and Pramipexole) and to Optimized Doses of Marketed Extended‐Release Pramipexole in Early Parkinson's Disease
Authors: Olanow C. Warren , Hauser Robert A. , Burdick Daniel J. , Dhall Rohit , de Marcaida Joy Antonelle , Gil Ramon A. , Kreitzman David L. , Elmer Lawrence W. , McGarry Andrew , Kieburtz Karl ,   for the P2B Study Group
Published: October 2023

AbstractBackgroundThere remains uncertainty as to the optimal way to initiate therapy for Parkinson's disease (PD) to maximize benefit and minimize adversity.ObjectivesThe objective was to determine if P2B001 (a fixed, low‐dose, extended‐release [ER] combination of pramipexole 0.6 mg and rasagiline 0.75 mg) is superior to each of its components and compare its safety and efficacy to optimized treatment with marketed doses of pramipexole‐ER.MethodsThis was a 12‐week, double‐blind study (NCT03329508). Total of 544 untreated patients with PD were randomized (2:2:2:1) to treatment with P2B001, its individual components (pramipexole‐ER 0.6 mg or rasagiline‐ER 0.75 mg), or commercial doses of pramipexole‐ER titrated to optimal dose (1.5–4.5 mg). The primary endpoint was change from baseline to week 12 in Unified Parkinson's Disease Rating Scale (UPDRS) parts II and III. The key secondary endpoint was the change from baseline in the Epworth Sleepiness Scale (ESS) for P2B001 versus the titrated dose of pramipexole‐ER.ResultsP2B001 provided superior efficacy compared to each of its components; mean (95% CI) treatment differences in UPDRS II + III scores were −2.66 (95% CI, −4.33 to −1.00) versus pramipexole‐ER 0.6 mg (P = 0.0018) and − 3.30 (95% CI, −4.96 to −1.63) versus rasagiline‐ER 0.75 mg (P < 0.0001). P2B001 had comparable efficacy with the titrated dose of pramipexole‐ER (mean, 3.2 mg), but significantly less worsening in daytime‐sleepiness (ESS treatment difference: −2.66 [95% CI, −3.50 to −1.81]; P < 0.0001). P2B001 was well‐tolerated with fewer sleep‐related and dopaminergic adverse events than titrated doses of pramipexole‐ER including somnolence, orthostatic hypotension, and neuropsychiatric side effects.ConclusionsP2B001 had superior efficacy to its individual components and was comparable with commercially used doses of pramipexole‐ER with less worsening of sleepiness and fewer dopaminergic adverse events. These findings support considering once‐daily P2B001 as initial therapy for patients with early PD. © 2023 International Parkinson and Movement Disorder Society.
Childhood cancer data initiative: Status report
Authors: Jagu Subhashini , Mardis Elaine R. , Wedekind Mary F. , Widemann Brigitte C. , Kingery Rena K. , Gonzalez Samantha L. , Shern Jack F. , Reaman Gregory H. 
Published: October 2023

AbstractIn March 2023, over 800 researchers, clinicians, patients, survivors, and advocates from the pediatric oncology community met to discuss the progress of the National Cancer Institute's Childhood Cancer Data Initiative. We present here the status of the initiative's efforts in building its data ecosystem and updates on key programs, especially the Molecular Characterization Initiative and the planned Coordinated National Initiative for Rare Cancers in Children and Young Adults. These activities aim to improve access to childhood cancer data, foster collaborations, facilitate integrative data analysis, and expand access to molecular characterization, ultimately leading to the development of innovative therapeutic approaches.
Polymerization‐induced self‐assembly for drug delivery: A critical appraisal
Authors: Hochreiner Eleonora G. , van Ravensteijn Bas G. P. 
Published: October 2023

AbstractPolymerization‐induced self‐assembly (PISA) with (in situ) encapsulation of (therapeutic) cargo has proven to be an efficient preparation method for loaded polymeric micelles and polymersomes, thereby presenting significant opportunities in the field of drug delivery. However, despite extensive research efforts, no significant advances toward systematic in vivo studies or clinical applications have been achieved to date. In this Review, we outline the current state‐of‐the‐art of cargo encapsulation via PISA with a specific focus on developments achieved in the past 5 years. Considering the general requirements for functional drug delivery systems, we identify the major hurdles that still need to be overcome in order to push PISA‐derived systems from a promising academic exercise to viable candidates for clinical translation.
Modelling the dynamics of hydrogen synthesis from methane in nanosecond‐pulsed plasmas
Authors: Morais Eduardo , Bogaerts Annemie 
Published: October 2023

AbstractA chemical kinetics model was developed to characterise the gas‐phase dynamics of H2 production in nanosecond‐pulsed CH4 plasmas. Pulsed behaviour was observed in the calculated electric field, electron temperature and species densities at all pressures. The model agrees reasonably with experimental results, showing CH4 conversion at 30% and C2H2 and H2 as major products. The underlying mechanisms in CH4 dissociation and H2 formation were analysed, highlighting the large contribution of vibrationally excited CH4 and H2 to coupling energy from the plasma into gas‐phase heating, and revealing that H2 synthesis is not affected by applied pressure, with selectivity remaining unchanged at ~42% in the 1–5 bar range.
The role of plasma concentrations and drug characteristics of beta‐blockers in fall risk of older persons
Authors: Ploegmakers K. J. , van Poelgeest E. P. , Seppala L. J. , van Dijk S. C. , de Groot L. C. P. G. M. , Oliai Araghi S. , van Schoor N. M. , Stricker B. , Swart K. M. A. , Uitterlinden A. G. , Mathôt R. A. A. , van der Velde N. 
Published: October 2023

AbstractBeta‐blocker usage is inconsistently associated with increased fall risk in the literature. However, due to age‐related changes and interindividual heterogeneity in pharmacokinetics and dynamics, it is difficult to predict which older adults are more at risk for falls. Therefore, we wanted to explore whether elevated plasma concentrations of selective and nonselective beta‐blockers are associated with an increased risk of falls in older beta‐blocker users. To answer our research question, we analyzed samples of selective (metoprolol, n = 316) and nonselective beta‐blockers (sotalol, timolol, propranolol, and carvedilol, n = 179) users from the B‐PROOF cohort. The associations between the beta‐blocker concentration and time to first fall were assessed using Cox proportional hazard models. Change of concentration over time in relation to fall risk was assessed with logistic regression models. Models were adjusted for potential confounders. Our results showed that above the median concentration of metoprolol was associated with an increased fall risk (HR 1.55 [1.11–2.16], p = .01). No association was found for nonselective beta‐blocker concentrations. Also, changes in concentration over time were not associated with increased fall risk. To conclude, metoprolol plasma concentrations were associated with an increased risk of falls in metoprolol users while no associations were found for nonselective beta‐blockers users. This might be caused by a decreased β1‐selectivity in high plasma concentrations. In the future, beta‐blocker concentrations could potentially help clinicians estimate fall risk in older beta‐blockers users and personalize treatment.
Investigation of the human metabolism and disposition of the prolyl hydrolase inhibitor daprodustat using IV microtracer with Entero‐Test bile string
Authors: Tai Guoying , Xia Fangming , Chen Cathy , Pereira Adrian , Pirhalla Jill , Miao Xiusheng , Young Graeme , Beaumont Claire , Chen Liangfu 
Published: October 2023

AbstractDaprodustat is an oral small molecule hypoxia‐inducible factor (HIF) prolyl hydroxylase inhibitor (PHI) approved in Japan and the United States for the treatment of anemia associated with chronic kidney disease. This phase 1, nonrandomized, 2‐period, crossover study in 6 healthy men characterized and quantified the metabolites generated after a microtracer IV infusion of 50 μg (125 nCi) [14C]‐daprodustat administered concomitantly with a nonradiolabeled therapeutic dose of a 6‐mg daprodustat tablet, followed by a single oral solution dose of 25 mg (62.5 μCi) [14C]‐daprodustat. High‐performance liquid chromatography (HPLC) coupled with radioactivity detection (TopCount or AMS) and HPLC‐tandem mass spectrometry (HPLC‐MSn) were used for quantitative measurement and structural identification of radioactive metabolites in plasma, urine, feces, and bile. Following oral administration of [14C]‐daprodustat, unchanged daprodustat was the principal circulating drug‐related component, accounting for 40% of plasma radioactivity. Predominant oxidative metabolites M2, M3, M4, and M13 individually represented 6–8% of the plasma radioactivity and together accounted for the majority of radioactivity in urine and feces (53% in both matrices; 12% and 41% of dose, respectively). Unchanged daprodustat was not detected in urine and was only 0.7% of total radioactivity in feces (<0.5% of dose), with the remainder of the dose accounted for by oxidative metabolites. The radio‐metabolic profile of duodenal bile following IV infusion of [14C]‐daprodustat was similar to that observed in feces after oral administration. The data suggested that oral daprodustat was extensively absorbed, cleared exclusively by oxidative metabolism, and eliminated via hepatobiliary (primary) and urinary (secondary) excretion.
Thoracic SMARCA4‐deficient undifferentiated tumour: Diagnostic challenges and potential for misdiagnosis in small tissue samples
Authors: Maartens Deborah Johanna , Moolla Muhammad Saadiq , Ndaba Sibusiso , Vlok Sucari Susanna Catherina , Hendricks Firzana , Koegelenberg Coenraad Frederik Nicolaas , van Wyk Abraham Christoffel 
Published: October 2023

AbstractWe report a diagnostically challenging case of a SMARCA4‐deficient undifferentiated tumour to emphasize its potential to mimic other malignant tumours on histology, especially in small biopsies and where rhabdoid morphology is lacking. A 48‐year‐old man, who was known for chronic obstructive pulmonary disease and polysubstance use, presented with dyspnoea and an anterior mediastinal mass that had grown rapidly over a seven‐month period. The rapid growth and location in the anterior mediastinum raised clinical suspicion for lymphoma or a germ cell tumour. Microscopic examination of a transthoracic, ultrasound‐guided, core needle biopsy revealed relatively uniform, malignant epithelioid cells with clear cytoplasm, but lacking any rhabdoid features. Tumour necrosis was prominent. The immunohistochemistry panel was negative for lymphoma markers, but positive for SALL4 (a marker typically associated with germ cell tumours), CD34, EMA, and HepPar1, while expression of SMARCA4 and claudin‐4 was entirely lost. Only focal cytokeratin expression was demonstrated. SMARCB1 (INI1) expression was retained. The diagnosis of SMARCA4‐DUT was made based on these findings. Unfortunately, the tumour was already at an advanced stage at diagnosis (stage IVA) and the patient had a poor performance status. He was treated with palliative radiotherapy with no significant improvement in performance status and passed away 3 months after diagnosis. The case highlights the importance of considering SMARCA4‐DUT in the differential diagnosis of an undifferentiated, rapidly growing thoracic tumour and the potential for misdiagnosis on a small tissue sample, particularly as rhabdoid morphology may be absent.
Stability analysis of nonlinear fuzzy hybrid control systems subject to saturation and delays via step‐function method
Authors: Qiu Ruiyang , Li Ruihai , Qiu Jianbin 
Published: October 2023

AbstractWithin the framework of the step‐function method, the stability of a nonlinear fuzzy hybrid control system that incorporates both an impulsive controller and a continuous state feedback controller is investigated. Both the two controllers are assumed to be subject to both actuator saturation and time‐varying delays, which has been given scant attention, if any, in the existing studies. A new assumption is introduced in this article, thereby enabling the use of generalized sector conditions to tackle the double saturation, and the conservatism inherent in stability results is remarkably reduced owing to the improved step‐function approach employed. The stability theorem proposed in this article removes constraints imposed on the time delays of both controllers, which can be also applied to wider scopes of systems, encompassing hybrid control systems with both stabilizing and instabilizing impulses, systems with varying impulsive gain, and systems with Zeno behavior. Numerical simulations of stabilization for different systems by delayed saturated hybrid control have been conducted, which demonstrate the validity of the proposed theorems.
Dual‐mode event‐triggered predictive control for nonlinear systems with bounded disturbances
Authors: Du Shengli , Zhao Mingming , Wang Xue‐Fang , Han Honggui , Qiao Junfei 
Published: October 2023

AbstractIn this article, we propose a dual‐mode event‐triggered predictive control method for nonlinear systems with bounded disturbances. The proposed method contains two triggering mechanisms, namely, the hybrid threshold‐based event‐triggered model predictive control (HETMPC) mechanism and the event‐triggered linear quadratic regulator mechanism. The former triggering mechanism is designed based on the error between the real state and the optimal state and also the disturbance information acted on the investigated system. Compared with the traditional fixed triggering threshold, the designed HETMPC has a fewer triggering numbers and reduces the computational burden of online real‐time optimization. This event‐triggered mechanism will be adopted before the states go into the terminal invariant set. The latter event‐triggered mechanism is designed based on the derivation of the system state and it will be adopted after the states enter the terminal invariant set. The feasibility and the input‐to‐state practical stability analysis of the designed strategy is presented. Some simulations, including the application to a mass‐spring‐damper system, are provided to show the correctness and feasibility of the designed algorithms.
Hydrogel‐Based Biosensors for Bacterial Infections
Authors: Sun Xiaoning , Ding Chunmei , Qin Meng , Li Jianshu 
Published: October 2023

AbstractHydrogels are known to have the advantages such as good biodegradability, biocompatibility, and easy functionalization, making them ideal candidates for biosensors. Hydrogel‐based biosensors that respond to bacteria‐induced microenvironmental changes such as pH, enzymes, antigens, etc., or directly interact with bacterial surface receptors, can be applied for early diagnosis of bacterial infections, providing information for timely treatment while avoiding antibiotic abuse. Furthermore, hydrogel biosensors capable of both bacteria diagnosis and treatment will greatly facilitate the development of point‐of‐care monitoring of bacterial infections. In this review, the recent advancement of hydrogel‐based biosensors for bacterial infection is summarized and discussed. First, the biosensors based on pH‐sensitive hydrogels, bacterial‐specific secretions‐sensitive hydrogels, and hydrogels directly in contact with bacterial surfaces are presented. Next, hydrogel biosensors capable of detecting bacterial infection in the early stage followed by immediate on‐demand treatment are discussed. Finally, the challenges and future development of hydrogel biosensors for bacterial infections are proposed.
Experimental study on the cracking behavior of anchorage zones
Authors: Marchão Carla , Marreiros Rui , Ribeiro Filipe 
Published: October 2023

AbstractWith the aim of studying the cracking behavior of anchorage zones of post‐tensioning tendons, an experimental research has been performed. The experimental program included eight prismatic specimens with 265 mm × 265 mm × 580 mm and 300 mm × 300 mm × 600 mm, reinforced with combinations of spirals and stirrups. The studied variables included the cross‐section dimensions and the amount of confining stirrups. In this study special anchorage devices were used in all specimens, which are commonly used in everyday practice. To be able to fulfill the loading protocol, concrete strains were measured. These values were also used to study the cracking loads and crack widths, and to assess the influence of the different studied variables, as well as the failure loads. Models from the literature were used to estimate the expected values for cracking loads. These values were compared with the experimental ones to verify their adequacy for the tested specimens. From the experimental tests, it can be concluded that the increase of the stirrup diameter leads to lower cracking loads. The increase of the cross‐section dimensions results in an increase in the cracking load. Available theories for estimating the cracking load do not provide satisfactory predictions of the expected cracking load.
Dynamics of Myers-Perry black holes with almost equal angular momenta in odd dimensions
Authors: Suzuki Ryotaku , Tomizawa Shinya 
Published: October 2023

Abstract
We investigate the nonlinear dynamics of D = 2N + 3 Myers-Perry black holes with almost equal angular momenta, which have N equal spins out of possible N + 1 spins. In particular, we study the ultraspinning instability and the fate of its nonlinear evolution using the large D effective theory approach. We find that every stationary phase can be mapped to the counterpart in the singly rotating phase within the leading order effective theory. From the known results of singly rotating solutions, we obtain the phase diagram of almost equally rotating black holes. We also obtain a certain implication for the possible topology changing transition.
Potential benefits of routine cystoscopy and vaginoscopy prior to reconstructive surgery in patients with an anorectal malformation
Authors: de Beaufort Cunera M. C. , Boom Daphne T. , Mackay Tara M. , Dekker Judith J. M. L. , Arguedas Flores Olga E. , de Jong Justin R. , Kuijper Caroline F. , Gorter Ramon R. 
Published: October 2023

Abstract
Purpose
First, to assess the number of patients with anorectal malformations (ARM) in whom additional urological and/or gynecological anomalies were identified through routine screening with cysto- or vaginoscopy prior to reconstructive surgery. Second, to assess potential procedure-related complications.

Methods
Retrospective mono-center cohort study, including all ARM patients born between January 2019 and December 2022. Routine screening consisted of cystoscopy for male patients, with the addition of vaginoscopy for female patients. Chi-square was used to compare the screening percentages over time.

Results
In total, 38 patients were included, of whom 27 (71.1%) underwent cystoscopy ± vaginoscopy, without the occurrence of complications. Nine of 13 females (69.2%) underwent cysto- and vaginoscopy and 18 of 25 males (72.0%) underwent a cystoscopy. The percentage of patients that underwent these procedures improved over the 2 time periods (50.0% in 2019–2020 vs 90.0% in 2021–2022, p = 0.011). In 15 of 27 patients (55.6%) that underwent cystoscopy ± vaginoscopy, additional anomalies were found that were not identified through physical examination or US-kidney.

Conclusions
In 56% of the patients that underwent cysto- ± vaginoscopy, additional anomalies were identified that were not with imaging studies or physical examination. This study emphasizes the potential benefit of routine cysto- and vaginoscopy in the diagnostic work-up of children with ARM.
Level of Evidence: III.
Early-onset restrictive food intake disorders in children: a latent class analysis
Authors: Stordeur Coline , Ayrolles Anaël , Trebossen Vincent , Barret Ségolène , Baillin Florence , Poncet-Kalifa Hélène , Meslot Carine , Clarke Julia , Bargiacchi Anne , Peyre Hugo , Delorme Richard 
Published: October 2023

AbstractThe two most frequent early-onset restrictive food intake disorders are early-onset anorexia nervosa (EOAN) and avoidant/restrictive food intake disorders (ARFID). Although the core symptoms of EOAN (i.e., fear of gaining weight and disturbed body image) are not present in ARFID, these symptoms are difficult to assess during the initial phase of hospitalisation. Our aim was to identify restrictive food intake disorder subtypes in children using latent class analysis (LCA) based on the information available at admission to hospital, and to determine the agreement between the subtypes identified using LCA and the final diagnosis: EOAN or ARFID. We retrospectively included 97 children under 13 years old with severe eating disorders (DSM-5) at their first hospitalisation in a specialised French paediatric unit. LCA was based on clinical information, growth chart analyses and socio-demographic parameters available at admission. We then compared the probabilities of latent class membership with the diagnosis (EOAN or ARFID) made at the end of the hospitalisation. The most parsimonious LCA model was a 2-class solution. Children diagnosed with EOAN at the end of hospitalisation had a 100% probability of belonging to class 1 while children diagnosed with ARFID had an 8% probability of belonging to class 1 based on parameters available at admission. Our results indicate that clinical and socio-demographic characteristics other than the core symptoms of EOAN may be discriminating for a differential diagnosis.