bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuralgische Amyotrophie – eine entzündliche
Neuropathie und ihre operative Behandlung
Authors: Pöschl Peter , Pham Mirko , Pedro Maria Teresa , Antoniadis Gregor 
Published: January 2024

Zusammenfassung
Hintergrund  Die Neuralgische Amyotrophie (NA) ist eine mono- bzw.
oligofokale entzündliche Neuropathie, deren Inzidenz deutlich
unterschätzt wurde. Ein Zusammenhang von Konstriktionen und Torsionen an
peripheren Nerven mit dieser Erkrankung konnte in den letzten Jahren zunehmend
hergestellt werden. Moderne bildgebende Verfahren wie hochauflösender
Nervenultraschall und die MR-Neurographie haben dazu beigetragen, die
Pathophysiologie besser zu verstehen und die Prognose der Erkrankung besser
einschätzen zu können. Daraus hat sich das Konzept entwickelt,
Patienten mit solchen fokalen Veränderungen einer operativen Therapie
zuzuführen, um die Prognose zu verbessern. Die folgende Arbeit stellt
aktuelle Vorstellungen zu Pathophysiologie, Klinik und Diagnostik und Therapie
der Erkrankung dar.
Patienten und Methoden In einer retrospektiven Studie wurden die
prä-, intra- und postoperativen Befunde bei 22 Patienten mit 23
Konstriktionen/Torsionen an peripheren Nerven der oberen
Extremität analysiert. Die Patienten wurden in einem Zeitraum von 3,5
Jahren (Dez. 2019–Mai 2023) in einem nervenchirurgischen Zentrum
operiert. Am häufigsten war der N. medianus (N=9), gefolgt von
N. suprascapularis (N=6) und N. radialis (N=4) betroffen. Ferner
waren der N. axillaris (N=3) und der N. accessorius (N=1)
beteiligt. Bei der operativen Exploration fanden sich Nerventorsionen
(N=9), Nervenkonstriktionen (N=5), faszikuläre Torsionen
(N=12) und faszikuläre Konstriktionen (N=9). Je nach
intraoperativem Befund wurden Epineuriotomien (N=1), Epi- und
Perineuriotomien (N=33), End-zu-End-Nähte (N=2), und je
eine epi- und perineurale Naht vorgenommen.
Ergebnisse Nach einer Nachbeobachtungszeit von durchschnittlich 10 Monaten
(3-28 Monate) gaben alle 17 erneut untersuchten Patienten eine eindeutige
subjektive Besserung der motorischen Ausfälle an. Klinisch und
elektromyographisch konnte bei diesen Patienten eine Reinnervation und deutliche
Kraftzunahme von einem vorbestehenden Kraftgrad M0 zu mindestens M3, in der
überwiegenden Mehrheit der betroffenen Muskeln nachgewiesen werden.
Zusammenfassung Die NA ist eine Erkrankung, deren Inzidenz weiterhin
unterschätzt wird und die bei einem erheblichen Anteil der Patienten zu
permanenten motorischen Defiziten führt, die mit hoher
Wahrscheinlichkeit Konstriktionen und Torsionen der betroffenen Nerven
geschuldet sind. Eine möglichst frühzeitige operative Therapie
dieser Patienten ist zu empfehlen. Mit einer Epi- und Perineuriotomie
können in der Regel sehr gute Ergebnisse erzielt werden. In seltenen
Fällen sind eine End-zu-End-Naht oder eine autologe Transplantation
erforderlich.
Cannabidiol and its Potential Evidence-Based Psychiatric Benefits
– A Critical Review
Authors: Dammann Inga , Rohleder Cathrin , Leweke F. Markus 
Published: January 2024

AbstractThe endocannabinoid system shows promise as a novel target for treating
psychiatric conditions. Cannabidiol (CBD), a naturally occurring cannabinoid,
has been investigated in several psychiatric conditions, with diverse effects
and an excellent safety profile compared to standard treatments. Even though the
body of evidence from randomised clinical trials is growing, it remains
relatively limited in most indications. This review comprises a comprehensive
literature search to identify clinical studies on the effects of CBD in
psychiatric conditions. The literature search included case studies, case
reports, observational studies, and RCTs published in English before July 27,
2023, excluding studies involving nabiximols or cannabis extracts containing CBD
and ∆9-tetrahydrocannabinol. Completed studies were
considered, and all authors independently assessed relevant publications.Of the 150 articles identified, 54 publications were included, covering the
effects of CBD on healthy subjects and various psychiatric conditions, such as
schizophrenia, substance use disorders (SUDs), anxiety, post-traumatic stress
disorder (PTSD), and autism spectrum disorders. No clinical studies have been
published for other potential indications, such as alcohol use disorder,
borderline personality disorder, depression, dementia, and
attention-deficit/hyperactivity disorder. This critical review
highlights that CBD can potentially ameliorate certain psychiatric conditions,
including schizophrenia, SUDs, and PTSD. However, more controlled studies and
clinical trials, particularly investigating the mid- to long-term use of CBD,
are required to conclusively establish its efficacy and safety in treating these
conditions. The complex effects of CBD on neural activity patterns, likely by
impacting the endocannabinoid system, warrant further research to reveal its
therapeutic potential in psychiatry.
Die standardisierte Erfassung psychosozialer Hilfebedarfe innerhalb
der psychiatrischen Akutbehandlung im sozialpädagogischen
Beratungskontext
Authors: Wills Christin 
Published: January 2024

ZusammenfassungBei Menschen mit psychischen Erkrankungen liegen häufig komplexe soziale
Problemlagen vor. Bisher gibt es in der akutpsychiatrischen Versorgung keine
systematisierte/standardisierte Erfassung von sozialen Hilfebedarfen.
Ein Grund hierfür ist der Mangel an adäquaten Instrumenten und
die zunehmende Arbeitsverdichtung. Die Übersichtsarbeit analysiert
etablierte Bedarfserhebungsinstrumente hinsichtlich der Eignung zur Bearbeitung
der Fragestellung. Es wird deutlich, dass diese Instrumente ungenügend
geeignet für eine strukturierte Erfassung des psychosozialen
Hilfebedarfs sind. Hieraus ergibt sich die Notwendigkeit für die
Entwicklung eines kurzen und standardisierten Instruments zur Erfassung des
psychosozialen Hilfebedarfs, welches als Teil der multiprofessionellen
Diagnostik innerhalb der psychiatrischen Versorgung eingesetzt werden kann.
Relationship Between Fasting Blood Glucose and Readmission Within 1
Year in Elderly Patients with Heart Failure
Authors: Wang Danning , Wu Sumin 
Published: January 2024

Abstract
Introduction Elevated blood glucose has been linked to unfavorable
outcomes among individuals with heart failure (HF). Nevertheless, evidence is
scarce regarding the association between fasting blood glucose (FBG) levels and
the likelihood of readmission within one year for elderly patients. To address
this gap, a retrospective cohort study was conducted, integrating electronic
health records of restricted health data from PhysioNet.
Methods The study focused on HF patients aged 60 years and older,
utilizing baseline data, comorbidities, and laboratory test results as
covariates. A total of 374 patients were included in the study. The relationship
between 1-year readmission rates and various glucose levels was assessed using
Kaplan-Meier plots. The analysis employed three multivariate Cox regression
models to examine patients with varying glucose levels.
Results Following adjustments for relevant factors, an association was
observed between FBG levels and the rate of readmission in elderly patients with
HF (HR=1.0264 [95% CI 0.9994–1.0541]). The diabetes
group faced a higher risk of readmission compared to the normal group. However,
this difference in outcome events was not statistically significant, with hazard
ratios and their corresponding 95% confidence intervals of 1.2134
(0.9811~1.5007), 1.2393 (0.9993~1.5371), and 1.1905
(0.9570~1.4809), respectively. The robustness of the model was further
demonstrated through risk models with subgroup analysis, revealing that FBG
levels consistently exerted a stable effect on outcome events, unaffected by
covariates such as age, gender, body mass index, glomerular filtration rate, and
brain natriuretic peptide.
Conclusion These findings suggest a notable association between elevated
FBG at the time of initial hospitalization and the likelihood of readmission
within one year among elderly patients with HF.
Predictors of persistent pain after extracorporeal shockwave lithotripsy for painful chronic calcific pancreatitis
Authors: Gurav Nitish , Jagtap Nitin , Koppoju Vinod , Sekhramantri Kiran , Asif Shujaath , Tandan Manu , Lakhtakia Sundeep , Kalapala Rakesh , Ramchandani Mohan , Talukdar Rupjyoti , Basha Jahangeer , Nabi Zaheer , Memon Sana Fatima , Darisetty Santosh , Rao Guduru Venkat , Reddy D. Nageshwar 
Published: January 2024

Abstract
Background Extracorporeal shockwave lithotripsy (ESWL) and/or endoscopic retrograde cholangiopancreatography (ERCP) are recommended as first-line therapy for painful uncomplicated chronic pancreatitis with obstructed main pancreatic duct (MPD) in the pancreas head/body. However, predictors of pain relief after ESWL are unknown. We evaluated independent predictors of persistent pain in patients who underwent ESWL for chronic pancreatitis.
Methods 640 consecutive adult patients with chronic pancreatitis, who underwent successful ESWL with ERCP and pancreatic duct (PD) stent placement, were followed for 12 months. The pain was assessed at baseline and at 12 months using the Izbicki Pain Score, with a score decrease of >50% considered pain relief. Independent predictors of pain relief were derived from logistic regression analysis.
Results Of 640 patients (mean age 36.71 [SD 12.19] years; 60.5% men), 436 (68.1%) had pain relief and 204 (31.9%) had persistent pain. On univariate analysis, older age, male sex, alcohol and tobacco intake, longer duration of symptoms, dilated MPD and MPD stricture were associated with persistent pain at 12 months (P<0.05). Consumption of alcohol (odds ratio [OR] 1.93, 95%CI 1.26–2.97), tobacco (OR 4.09, 95%CI 2.43–6.90), duration of symptoms (OR 1.02, 95%CI 1.01–1.04), MPD size (OR 1.22, 95%CI 1.11–1.33), and MPD stricture (OR 8.50, 95%CI 5.01–14.42) were independent predictors of persistent pain.
Conclusions Alcohol, tobacco, duration of symptoms, MPD size and stricture were independent predictors of persistent pain after successful ESWL. A multidisciplinary team approach that includes behavioral therapy and surgical options should be considered for such patients.
Determinants of V̇+O2peak Changes After Aerobic Training
in Coronary Heart Disease Patients
Authors: Girault Axel , Leprêtre Pierre-Marie , Trachsel Lukas-Daniel , Besnier Florent , Boidin Maxime , Lalongé Julie , Juneau Martin , Bherer Louis , Nigam Anil , Gayda Mathieu 
Published: January 2024

AbstractThis study aimed to highlight the ventilatory and circulatory determinants of
changes in ˙VO2peak after exercise-based cardiac rehabilitation (ECR)
in patients with coronary heart disease (CHD). Eighty-two CHD patients
performed, before and after a 3-month ECR, a cardiopulmonary exercise testing
(CPET) on a bike with gas exchanges measurements (˙VO2peak, minute
ventilation, i. e., ˙VE), and cardiac output (Q˙c). The arteriovenous difference
in O2 (C(a-v¯)O2) and the alveolar capillary gradient in
O2 (PAi-aO2) were calculated using Fick’s laws. Oxygen
uptake efficiency slope (OUES) was calculated. A 5.0% cut off was applied for
differentiating non- (NR: ˙VO2<0.0%), low (LR: 0.0≤
∆˙VO2<5.0%), moderate (MR: 5.0≤∆˙VO2 < 10.0%),
and high responders (HR: ∆˙VO2≥10.0%) to ECR. A total of 44% of
patients were HR (n=36), 20% MR (n=16), 23% LR (n=19), and 13% NR (n=11). For
HR, the ˙VO2peak increase (p<0.01) was associated with increases
in ˙VE (+12.8±13.0 L/min, p<0.01),
(+1.0±0.9 L/min, p<0.01), and C(a-v¯)O2
(+2.3±2.5 mLO2/100 mL, p<0.01). MR patients were characterized
by+6.7±19.7 L/min increase in ˙VE (p=0.04) and+0.7±1.0 L/min of Q˙c (p<0.01). ECR induced decreases in
˙VE (p=0.04) and C(a-v¯)O2 (p<0.01) and a Q˙c increase in LR and NR patients
(p<0.01). Peripheral and ventilatory responses more than central adaptations
could be responsible for the ˙VO2peak change with ECR in CHD
patients.
Optimal Delivery Management for the Prevention of Early Neonatal SARS-CoV-2 Infection: Systematic Review and Meta-analysis
Authors: Chan Christina S. , Kong Juin Yee , Sultana Rehena , Mundra Vatsala , Babata Kikelomo L. , Mazzarella Kelly , Adhikari Emily H. , Yeo Kee Thai , Hascoët Jean-Michel , Brion Luc P. 
Published: January 2024

Objective Delivery management interventions (DMIs) were recommended to prevent delivery-associated transmission of maternal SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) to infants without evidence of effect on early neonatal SARS-CoV-2 infection (ENI) and neonatal death <28 days of life (ND). This systematic review describes different DMI combinations and the frequency of ENI and ND.
Study Design Individual patient data were collected from articles published from January 1, 2020 to December 31, 2021 from Cochrane review databases, Medline, and Google Scholar. Article inclusion criteria were: documented maternal SARS-CoV-2 polymerase chain reaction (PCR)-positive status 10 days before delivery or symptomatic at delivery with a positive test within 48 hours, known delivery method, and known infant SARS-CoV-2 PCR result. Primary outcomes were ENI (positive PCR at 12 hours to 10 days) and ND. All characteristics were pooled using the DerSimonian–Laird inverse variance method. Primary outcome analyses were performed using logit transformation and random effect. Pooled results were expressed as percentages (95% confidence intervals). Continuity correction was applied for all pooled results if any included study has 0 event.
Results A total of 11,075 publications were screened. 117 publications representing 244 infants and 230 mothers were included. All publications were case reports. ENI and ND were reported in 23.4% (18.2–29.18) and 2.1% (0.67–4.72) of cases, respectively. Among cases with available information, DMIs were reported for physical environment (85–100%), delivery-specific interventions (47–100%), and infant care practices (80–100%). No significant comparisons could be performed between different DMI combinations due to small sample size.
Conclusion The evidence supporting any DMI in SARS-CoV-2-infected mothers to prevent ENI or ND is extremely limited. Limitations of this meta-analysis include high risk of bias, small sample size, and large confidence intervals. This identifies the need for multinational database generation and specific studies designed to provide evidence of DMI guidelines best suited to prevent transmission from mother to neonate.
Key Points
Differential Diagnosis of “Foot Drop”: Implications for Peripheral Nerve Surgery
Authors: Seruya Mitchel 
Published: January 2024

Abstract
Background At least 128,000 patients in the United States each year suffer from foot drop. This is a debilitating condition, marked by the inability to dorsiflex and/or evert the affected ankle. Such patients are rendered to a lifetime of relying on an ankle-foot orthosis (AFO) for walking and nighttime to prevent an equinovarus contracture.
Methods This narrative review explores the differential diagnosis of foot drop, with a particular focus on clinical presentation and recovery, whether spontaneously or through surgery.
Results Contrary to popular belief, foot drop can be caused by more than just insult to the common peroneal nerve at the fibular head (fibular tunnel). It is a common endpoint for a diverse spectrum of nerve injuries, which may explain its relatively high prevalence. From proximal to distal, these conditions include lumbar spine nerve root damage, sciatic nerve palsy at the sciatic notch, and common peroneal nerve injury at the fibular head. Each nerve condition is marked by a unique clinical presentation, frequency, likelihood for spontaneous recovery, and cadre of peripheral nerve techniques.
Conclusion The ideal surgical technique for treating foot drop, other than neurolysis for compression, remains elusive as traditional peripheral nerve procedures have been marred by a wide spectrum of functional results. Based on a careful understanding of why past techniques have achieved limited success, we can formulate a working set of principles to help guide surgical innovation moving forward, such as fascicular nerve transfer.
Development of a Prediction Model for Surgery or Early Mortality at the Time of Initial Assessment for Necrotizing Enterocolitis
Authors: Nayak Sujir P. , Sánchez-Rosado Mariela , Reis Jordan D. , Brown L. Steven , Mangona Kate L. , Sharma Priya , Nelson David B. , Wyckoff Myra H. , Pandya Samir , Mir Imran N. , Brion Luc P. 
Published: January 2024

Objective No available scale, at the time of initial evaluation for necrotizing enterocolitis (NEC), accurately predicts, that is, with an area under the curve (AUC) ≥0.9, which preterm infants will undergo surgery for NEC stage III or die within a week.
Study Design This is a retrospective cohort study (n = 261) of preterm infants with <33 weeks' gestation or <1,500 g birth weight with either suspected or with definite NEC born at Parkland Hospital between 2009 and 2021. A prediction model using the new HASOFA score (Hyperglycemia, Hyperkalemia, use of inotropes for Hypotension during the prior week, Acidemia, Neonatal Sequential Organ Failure Assessment [nSOFA] score) was compared with a similar model using the nSOFA score.
Results Among 261 infants, 112 infants had NEC stage I, 68 with NEC stage II, and 81 with NEC stage III based on modified Bell's classification. The primary outcome, surgery for NEC stage III or death within a week, occurred in 81 infants (surgery in 66 infants and death in 38 infants). All infants with pneumoperitoneum or abdominal compartment syndrome either died or had surgery. The HASOFA and the nSOFA scores were evaluated in 254 and 253 infants, respectively, at the time of the initial workup for NEC. Both models were internally validated. The HASOFA model was a better predictor of surgery for NEC stage III or death within a week than the nSOFA model, with greater AUC 0.909 versus 0.825, respectively, p < 0.001. Combining HASOFA at initial assessment with concurrent or later presence of abdominal wall erythema or portal gas improved the prediction surgery for NEC stage III or death with AUC 0.942 or 0.956, respectively.
Conclusion Using this new internally validated prediction model, surgery for NEC stage III or death within a week can be accurately predicted at the time of initial assessment for NEC.
Key Points
A CT Radiologic Assessment of the Incidence of Cochlear–Facial Dehiscence and the Thickness of Bone between the Cochlea and Facial Nerve among Normal Temporal Bones
Authors: Nayeri Diba , Gopen Quinton 
Published: January 2024

AbstractCochlear–facial dehiscence (CFD) is a relatively new diagnosis which occurs when the bony partition between the labyrinthine segment of the facial nerve and the cochlea is dehiscent. This is considered one of several third window lesions which produce varying degrees of auditory and vestibular symptoms. Imaging studies have identified a consistently higher incidence of CFD when compared with the only histopathologic study present in the literature. This research effort adds to the literature using uniform computed tomography scan images across over 226 ears (114 patients) to identify the radiographic incidence of CFD in normal patients without ear pathology or symptoms. This study identified an incidence of 18.1% of the ears analyzed having dehiscence without any correlation to age or gender. When dehiscence was not identified, the mean thickness of bone between the cochlea and the facial nerve was 0.60 ± 0.24 mm.
A Systematic Review of Efficacy and Safety of Plasma-Derived von Willebrand Factor/Factor VIII Concentrate (Voncento) in von Willebrand Disease
Authors: Rugeri Lucia , Thomas Will , Schirner Kathrin , Heyder Lisa , Auerswald Günter 
Published: January 2024

Background For the treatment of von Willebrand disease (VWD), von Willebrand factor (VWF) concentrates can be used in on-demand, long-term prophylaxis, and surgical prophylaxis regimens.
Methods This systematic literature review was conducted to evaluate the efficacy, consumption, and safety of plasma-derived human coagulation FVIII/human VWF (pdVWF/FVIII; Voncento/Biostate) for the treatment of patients with any inherited VWD type. An electronic search was conducted in MEDLINE and Cochrane Library databases on VWD therapies. All retrieved publications were assessed against predefined inclusion/exclusion criteria following the Cochrane group recommendations. Associated pharmacovigilance data were collected across the same time period.
Results Eleven publications from eight study cohorts were identified for data retrieval. All were from multicenter studies and included both pediatric and adult patients. Eight publications included evaluations of the efficacy of pdVWF/FVIII for on-demand treatment, eight included long-term prophylactic treatment, and eight included surgical prophylaxis. Treatment protocols and VWF administration methods differed between studies, as did safety evaluations. The clinical response was rated as excellent/good for on-demand treatment in 66 to 100% of nonsurgical bleeds, 89 to 100% in the treatment of breakthrough bleeds during long-term prophylaxis treatment, and hemostatic efficacy in surgical procedures was 75 to 100%. Pharmacovigilance data confirmed a low incidence of adverse events in treated patients.
Conclusion This review provides a comprehensive summary of studies that evaluated the use of pdVWF/FVIII in VWD demonstrating the long-term effectiveness and safety of this pdVWF/FVIII across all ages, types of VWD, and treatment settings.
Synthesis of New Highly Functionalized Quinolines via a Novel FeIII-Catalyzed Domino aza-Michael/Aldol/Aromatization Reaction
Authors: Tsogoeva Svetlana B. , Heckmann Felix , Ibrahim Mohammad M. , Hampel Frank 
Published: January 2024

AbstractWe report the development of a straightforward, waste-reducing, environmentally friendly, FeIII-catalyzed domino aza-Michael/aldol/aromatization reaction in the presence of water to access high-value functionalized quinolines by using 2-aminobenzophenones and ethyl buta-2,3-dienoate as starting compounds. The tangible advantages, that is, the utilization of commercially available and/or easily accessible substrates, simplicity, mild reaction conditions, and application of water as a solvent, make this three-step domino process green and highly appealing for the direct construction of a wide variety of highly functionalized quinolines in up to 78% yield.
Cochlear Implant Activation in the Immediate Postoperative Period in the Operating Room
Authors: Wiemes Gislaine Richter Minhoto , Wiemes Nicole Richter Minhoto , Carvalho Bettina , Hamerschmidt Rogerio 
Published: January 2024

Abstract
Introduction Cochlear implant (CI) activation usually takes place at ∼ 30 days postoperative (PO). In our service, CI surgery is performed with local anesthesia and sedation, so activation is possible with the patient's cooperation, immediately after the CI surgery, still in the operating room (OR).
Objective The objective of the present study was to provide the patient with hearing experience with the CI and to assess auditory perception immediately after surgery while still in the OR, as well as to compare impedance telemetry (IT), neural response telemetry (NRT), and comfort (C) level at two moments: in the OR and at the definitive activation, ∼ 30 days PO.
Methods Nine adult patients (12 ears) with acquired (postlingual) deafness were included. Auditory perception was evaluated through the Ling Six Sound Check, musical instruments, and clapping, presented in two different programming maps, elaborated using t-NRT, and comparing IT, NRT, and C level between the two moments.
Results We observed that while still in the OR, the patient can already present auditory detection and recognition responses. The values of IT, NRT threshold (t-NRT), and C on both dates differed, with statistical significance.
Conclusion We concluded that it is possible to provide the patient with an auditory experience with the CI immediately after surgery, and that the auditory experience and the values of electrode IT, NRT, and C vary significantly between the two moments.