bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central nervous system tumours in neonates: what should the neonatologist know?
Authors: Toniutti Maristella , Sasso Annalisa Lo , Carai Andrea , Colafati Giovanna Stefania , Piccirilli Eleonora , Del Baldo Giada , Mastronuzzi Angela 
Published: January 2024

AbstractCentral nervous system (CNS) tumours in neonates are relatively rare and present differently when compared with those occurring later in childhood in terms of aetiology, clinical features, location, histology and prognosis. The clinical presentation is extremely variable. Even if the most frequent clinical sign is a macrocephaly, there are many other non-specific symptoms associated. The prognosis is usually poor with overall survival of less than 30%. Surgery continues to be the primary treatment for neonatal CNS tumours, aiming for a gross total resection, directly correlated with prognosis and the overall outcome. The chemotherapy is the only adjuvant therapy whereas the radiotherapy is avoided under three years of age because of the severe sequelae. Hence the importance of molecular characterization of these neoplasms in order to improve the accuracy of the diagnosis and identify new therapeutic targets. The aim of this review is to describe the main characteristics of these tumours and the recent advances in their treatment in order to recognize these pathologies in the prenatal period and create a multidisciplinary team providing the best possible treatment while minimising the risk of long-term complications. Neonatologists play a key role in the early detection, diagnostic evaluation, management and supportive care of these neonates. Conclusion: The aim of this review is to describe the main characteristics of these tumours and the recent advances in their treatment in order to ensure the essential knowledge that will help the neonatologist identify them and create a multidisciplinary team providing the best possible treatment while minimising the risk of long-term complications.

What is Known:• Neonatal CNS tumours are relatively rare and their early identification is important to identify the best diagnostic-therapeutic management.• Surgery is the main treatment of neonatal CNS tumours. The extent of surgical resection directly correlates with prognosis and outcome.

What is New:• Predisposing conditions such as Cancer Predisposition Syndromes must be considered.• Targeted drugs and other therapeutic strategies can be identified through molecular characterization
Looking inside the lab: a systematic literature review of economic experiments in health service provision
Authors: Finocchiaro Castro Massimo , Guccio Calogero , Romeo Domenica 
Published: January 2024

AbstractExperimental economics is, nowadays, a well-established approach to investigate agents’ behavior under economic incentives. In the last decade, a fast-growing number of studies have focused on the application of experimental methodology to health policy issues. The results of that stream of literature have been intriguing and strongly policy oriented. However, those findings are scattered between different health-related topics, making it difficult to grasp the overall state-of-the-art. Hence, to make the main contributions understandable at a glance, we conduct a systematic literature review of laboratory experiments on the supply of health services. Of the 1248 articles retrieved from 2011, 56 articles published in peer-review journals have met our inclusion criteria. Thus, we have described the experimental designs of each of the selected papers and we have classified them according to their main area of interest.
Engagement and accessibility tools for pro-environmental action on air quality: the SOCIO-BEE paradigm
Authors: Atutxa Ekhi , Garcia-Torres Sofia , Kyfonidis Charalampos , Karanassos Dimitrios , Kopsacheilis Evangelos , Tsita Christina , Casado-Mansilla Diego , Emvoliadis Alexandros , Angelis Georgios , López-de-Ipiña Diego , Puerta Maite , Drosou Anastasios , Tzovaras Dimitrios 
Published: January 2024

AbstractThe involvement of citizens and all stakeholders is crucial in tackling environmental and social matters. This, addressing equity and diversity issues, although challenging, is a necessary condition for achieving positive outcomes and ensuring that no one is left behind. To help ease this challenge, this work presents a systematic approach to ensure inclusive participation and leverage non-technical and technical elements to maximise stakeholder engagement in scientific activities to successfully address sustainability concerns. For that, it builds on the interim results of the H2020 SOCIO-BEE project, a Citizen science (CS) proposal to reduce air pollution through inclusive community engagement and social innovation. As part of an interdisciplinary CS project, an abductive systematic combining methodology was employed, which allowed for dialogue and collaboration between theory and practice throughout the whole process, during which separate groups of experts and potential end-users were involved. The article presents (i) the stakeholder engagement strategy codified in the SOCIO-BEE toolkit as a robust, actionable and inclusive foundation of engagement to CS activities; and (ii) the digital platform UX that allows setting up campaigns for measurements and assignment to citizens, incorporating the requirements for flexibility, accessibility, limited digital literacy, inclusion and legal and ethical considerations. Their combination and mutual interaction aim to leverage the pros of CS and technology whilst reducing their cons to ensure the four pillars of applicability, scalability, actionability, and inclusion. This is supported by the presented hybrid model which combines physical and virtual spaces and individual and collective action.
Eye tracking-based evaluation of accessible and usable interactive systems: tool set of guidelines and methodological issues
Authors: Molina Ana I. , Arroyo Yoel , Lacave Carmen , Redondo Miguel A. , Bravo Crescencio , Ortega Manuel 
Published: January 2024

AbstractThis paper describes some fundamentals and challenges in using eye tracking for the assessment of usability and accessibility in the fields in Human–Computer Interaction and Educational Computing. This technique has great potential since it allows considering human factors and individual differences in these areas. This non-invasive method, of physiological nature, allows to know, in an objective way, the visual behavior of the users when facing a user interface or educational material, allowing to infer conclusions related to psychological processes, such as attention or cognitive load. The purpose of this work is to propose a tool set of guidelines and measures, as well as a methodological approach, to be used in eye tracking assessments. This proposal is based on and validated by the authors’ previous experience and results in the application of this technique.
A Model for Low-Frequency, Anisotropic Wind Fluctuations and Coherences in the Marine Atmosphere
Authors: Syed Abdul Haseeb , Mann Jakob 
Published: January 2024

AbstractTo assess dynamic loads, large offshore wind turbines need detailed and reliable statistical information on the inflow turbulence. We present a model that includes low frequencies down to $$\sim 1$$

∼
1

hr$$^{-1}$$

-
1

using the observed $$S(f) \propto f^{-5/3}$$

S

(
f
)

∝

f

-
5
/
3

in that range. The presented model contains a parameter representing the anisotropy of the two-dimensional, incompressible turbulence, and it assumes the low-frequency fluctuations to be homogeneous in the vertical direction. Combined with a three-dimensional model for the smaller scales, the model can predict correlations between different points. We have validated the model against two offshore wind data sets: a nacelle-mounted, forward-looking Doppler lidar with four beams at the Hywind Scotland offshore wind farm and sonic anemometer measurements at the FINO1 research platform in the North Sea. One-point auto spectra and two-point cross spectra were calculated after splitting the data into different atmospheric stability classes. The relative strength of the 2D low-frequency fluctuations to the 3D fluctuations was higher under stable conditions. The combined 2D+3D model was able to fit the measured spectra with good accuracy and could then predict the two-point cross spectra, co-coherences, and phase angles between wind fluctuations at different lateral and vertical separations. Good agreement was found between the measured and predicted values, albeit with exceptions. The model can generate stochastic wind fields for investigating wake meandering in wind farms or dynamic loads on floating wind turbines.
Treatment patterns of patients with HR+/HER2- metastatic breast cancer receiving CDK4/6 inhibitor-based regimens: a cohort study in the French nationwide healthcare database
Authors: Read Stephanie H. , Quignot Nadia , Kapso-Kapnang Raissa , Comerford Erin , Zheng Ying , Gainford Corona , Sasane Medha , Vataire Anne-Lise , Delzongle Laure , Bidard Francois-Clement 
Published: January 2024

Abstract
Purpose
To assess real-world treatment patterns in patients diagnosed with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) metastatic breast cancer (mBC) who received cyclin-dependent kinase 4/6 (CDK4/6) inhibitors in combination with an aromatase inhibitor (AI) or fulvestrant at first line.

Methods
Patient characteristics, treatment history, and outcomes data were extracted from the French ‘Système National des Données de Santé’ (SNDS) database for patients diagnosed with HR+/HER2- mBC between January 2014 and June 2019 and who received combination therapy with a CDK4/6 inhibitor and endocrine therapy. Kaplan-Meier methodology was used to assess time to next treatment (TTNT) and time to treatment discontinuation (TTTD).

Results
The cohort comprised 6061 patients including 4032 patients who received CDK4/6 inhibitors + AIs and 2029 patients who received CDK4/6 inhibitors + fulvestrant. Median follow-up was 13.5 months (IQR 9.5–18.1). The median TTTD of first line treatment with CDK4/6 inhibitors + AIs and CDK4/6 inhibitors + fulvestrant was 17.3 months (95% CI 16.8–17.9) and 9.7 months (95% CI 9.0–10.2), respectively. Chemotherapy was the most common second line therapy. Median TTTD of subsequent treatment lines was progressively shorter following first line treatment with CDK4/6 inhibitors + AIs (2nd line: 4.6 months (95% CI 4.4–4.9) and with CDK4/6 inhibitors + fulvestrant (2nd line: 4.7 months (95% CI 4.3–5.1). TTNT was longer than TTTD across lines of therapy.

Conclusion
This real-world analysis confirms the effectiveness of CDK4/6 inhibitor-based regimens in French patients and highlights the frequent use of chemotherapy as second line therapy.
A portable low-cost device to quantify advective gas fluxes from mofettes into the lower atmosphere: First application to Starzach mofettes (Germany)
Authors: Büchau Yann Georg , Leven Carsten , Bange Jens 
Published: January 2024

AbstractIn this study, we introduce a portable low-cost device for in situ gas emission measurement from focused point sources of CO2, such as mofettes. We assess the individual sensors’ precision with calibration experiments and perform an independent verification of the system’s ability to measure gas flow rates in the range of liters per second. The results from one week of continuous CO2 flow observation from a wet mofette at the Starzach site is presented and correlated with the ambient meteorological dynamics. In the observed period, the gas flow rate of the examined mofette exhibits a dominant cycle of around four seconds that is linked to the gas rising upwards through a water column. We find the examined mofette to have a daily emission of 465 kg ±16 %. Furthermore, two events were observed that increased the flow rate abruptly by around 25 % within only a few minutes and a decaying period of 24 hours. These types of events were previously observed by others at the same site but dismissed as measurement errors. We discuss these events as a hydrogeological phenomenon similar to cold-water geyser eruptions. For meteorological events like the passages of high pressure fronts with steep changes in atmospheric pressure, we do not see a significant correlation between atmospheric parameters and the rate of gas exhalation in our one-week time frame, suggesting that on short timescales the atmospheric pumping effect plays a minor role for wet mofettes at the Starzach site.
Oxali-palladium nanoparticle synthesis, characterization, protein binding, and apoptosis induction in colorectal cancer cells
Authors: Golestannezhad Nasim , Divsalar Adeleh , Badalkhani-Khamseh Farideh , Rasouli Milad , Seyedarabi Arefeh , Ghalandari Behafarid , Ding Xianting , Goli Fatemeh , Bekeschus Sander , Movahedi Ali Akbar Moosavi , Moghadam Mahboube Eslami 
Published: January 2024

AbstractThis paper focuses on the synthesis of nano-oxali-palladium coated with turmeric extract (PdNPs) using a green chemistry technique based on the reduction in the Pd (II) complex by phytochemicals inherent in turmeric extract. PdNPs were examined and characterized using Field Emission Scanning Electron Microscopy (FESEM), Dynamic Light Scattering (DLS), Fourier Transform Infrared (FTIR), and Atomic Force Microscopy (AFM). Using different spectroscopic and molecular dynamics simulations, a protein-binding analysis of the produced nanoparticle was conducted by observing its interaction with human serum albumin (HSA). Lastly, the cytotoxic effects and apoptotic processes of PdNPs were studied against the HCT116 human colorectal cell line using the MTT assay and flow cytometry tests. According to the findings, PdNPs with spherical and homogenous morphology and a size smaller than 100 nm were generated. In addition, they can induce apoptosis in colorectal cancer cells in a dose-dependent manner with a lower Cc50 (78 µL) than cisplatin and free oxali-palladium against HCT116 cells. The thermodynamic characteristics of protein binding of nanoparticles with HSA demonstrated that PdNPs had a great capacity for quenching and interacting with HSA through hydrophobic forces. In addition, molecular dynamics simulations revealed that free oxali-palladium and PdNP attach to the same area of HSA via non-covalent interactions. It is conceivable to indicate that the synthesized PdNPs are a potential candidate for the construction of novel, nature-based anticancer treatments with fewer side effects and a high level of eco-friendliness.
Graphical Abstract
Dexamethasone release from hyaluronic acid microparticle and proanthocyanidin-gelatin hydrogel in sciatic tissue regeneration
Authors: Javanmardi Kazem , Shahbazi Hamideh , Soltani Hekmat Ava , Khanmohammadi Mehdi , Goodarzi Arash 
Published: January 2024

AbstractBiodegradable microparticles are useful vehicles for the controlled release of bioactive molecules in drug delivery, tissue engineering and biopharmaceutical applications. We developed dexamethasone (Dex) encapsulation into tyramine-substituted hyaluronic acid microparticles (Dex-HA-Tyr Mp) mediated by horseradish peroxidase (HRP) crosslinking using a microfluidic device and infollowing crosslinked gelatin (Gela) with proanthocyanidin (PA) as a semi-confined bed hydrogel for the repair of sciatic tissue injury. It was found that the simultaneous use of Dex-HA-Tyr Mp and cross-linked Gela-PA hydrogel improved the physical properties of the hydrogel, including mechanical strength and degradability. The designed composite also provided a sustained release system for Dex delivery to the surrounding sites, demonstrating the applicability of the fabricated hydrogel composite for sciatic nerve tissue engineering and regeneration. The encapsulated cells were viable and showed adequate growth ability and morphogenesis during prolonged incubation in Gela-PA/HA-Tyr Mp hydrogel compared to control conditions. Interestingly, histological analysis revealed a significant increase in the number of axons in the injured sciatic nerve following treatment with Dex-HA-Tyr Mp and injectable Gela-PA hydrogel compared to other control groups. In conclusion, the results demonstrated that fabricated Dex-loaded MPs and injectable hydrogel from biomimetic components are suitable systems for sustained delivery of Dex with adequate biocompatibility and the approach may have potential therapeutic applications in peripheral nerve regeneration.
Graphical Abstract
Universal Biomaterial-on-Chip: a versatile platform for evaluating cellular responses on diverse biomaterial substrates
Authors: Atif Abdul Raouf , Aramesh Morteza , Carter Sarah-Sophia , Tenje Maria , Mestres Gemma 
Published: January 2024

AbstractMicrofluidics has emerged as a promising approach for assessing cellular behavior in vitro, providing more physiologically relevant cell culture environments with dynamic flow and shear stresses. This study introduces the Universal Biomaterial-on-Chip (UBoC) device, which enables the evaluation of cell response on diverse biomaterial substrates in a 3D-printed microfluidic device. The UBoC platform offers mechanical stimulation of the cells and monitoring of their response on diverse biomaterials, enabling qualitative and quantitative in vitro analysis both on- and off-chip. Cell adhesion and proliferation were assessed to evaluate the biocompatibility of materials with different physical properties, while mechanical stimulation was performed to investigate shear-dependent calcium signaling in pre-osteoblasts. Moreover, the applicability of the UBoC platform in creating more complex in vitro models by culturing multiple cell types was demonstrated, establishing a dynamic multicellular environment to investigate cellular interfaces and their significance in biological processes. Overall, the UBoC presents an adaptable tool for in vitro evaluation of cellular behavior, offering opportunities for studying various biomaterials and cell interactions in microfluidic environments.
Graphical Abstract
Thermodynamic and structural change of Cu-13.5Al-4Ni shape memory alloy aged under different pressures for equal times
Authors: Balo Ş. Nevin , Manguri Hawbir Swara Ahmed 
Published: January 2024

AbstractIn this study, Cu-13.5Al-4Ni shape memory alloy (mass %) was tested. The alloy samples, at different pressures, were aged for an equal period of 5 min. The physical properties of Cu-13.5Al-4Ni alloy samples aged for an equal period were investigated. Differential scanning calorimetry (DSC) was used to investigate the impact on thermodynamic parameters. The differential thermal analysis (TG/DTA) measurements were made to obtain the ordered-disordered phase transformations from room temperature to 1200 °C. X-ray diffraction (XRD) and optic microscope observation were used to examine the microstructure. Microhardness measurements were performed on alloy samples aged for an equal period. The physical properties of the samples aged at different pressures for an equal period were compared to the measurement results of the homogenous sample.
Which factors determine adaptation to drought amongst farmers in Northern Thailand? Investigating farmers’ appraisals of risk and adaptation and their exposure to drought information communications as determinants of their adaptive responses
Authors: Sutcliffe Chloe , Holman Ian , Goodwin Daniel , Salmoral Gloria , Pardthaisong Liwa , Visessri Supattra , Ekkawatpanit Chaiwat , Rey Dolores 
Published: January 2024

AbstractDrought communications constitute an important source of learning about climate risks and responses that can assist adaptation decision-making amongst those whose livelihoods are threatened by drought. This paper applies Protection Motivation Theory to explore associations between drought communications and attitudes towards drought risk and adaptation amongst farmers in Northern Thailand. The analysis reveals links between drought communications, farmers’ adaptation appraisal, and their adaptation decisions, whilst links with risk appraisal are minimal. The results highlight positive feedbacks between adaptation experience and appraisal and reveal a weak negative relationship between risk appraisal and adaptation appraisal. The findings imply benefits to framing drought communications in terms of the efficacy and attainability of suitable adaptations, rather than simply highlighting drought risks or providing drought warnings, to best enable farmers to build drought resilience.
Performance evaluation of mpeg-5 part 2 (lcevc): impact of packet loss
Authors: Roberts George , Adeyemi-Ejeye Anthony 
Published: January 2024

AbstractThis paper presents an evaluation of the latest MPEG-5 Part 2 Low Complexity Enhancement Video Coding (LCEVC) for video streaming applications using best effort protocols. LCEVC is a new video standard by MPEG, which enhances any base codec through an additional low bitrate stream, improving both video compression efficiency and and transmission. However, there is an interplay between packetization, packet loss visibility, choice of codec and video quality, which implies that prior studies with other codecs may be not as relevant. The contributions of this paper is, therefore in twofold: It evaluates the compression performance of LCEVC and then the impact of packet loss on its video quality when compared to H.264 and HEVC.The results from this evaluation suggest that, regarding compression, LCEVC outperformed its base codecs, overall in terms average encoding bitrate savings when using the constant rate factor (CRF) rate control. For example at a CRF of 19, the average encoding bitrate was reduced by 18.7% and 15.8% when compared with the base H.264 and HEVC codecs respectively. Furthermore, LCEVC produced better visual quality across the packet loss range compared to its base codecs and the quality only started to decrease once packet loss exceeded 0.8-1%, and decreases at a slower pace compared to its equivalent base codecs. This suggests that the LCEVC enhancement layer also provides error concealment. The results presented in this paper will be of interest to those considering the LCEVC standard and expected video quality in error-prone environments
Facet analysis in data envelopment analysis: some pitfalls of the CRS models
Authors: Olesen O. B. , Petersen N. C. 
Published: January 2024

AbstractThe nonparametric estimator of the Extended Facet reference technology for the Constant Returns to Scale case has attracted some attention, because the associated production frontier by construction does only include strongly efficient faces of maximal dimension, or strongly efficient faces that are part of such strongly efficient faces of maximal dimension. The strongly efficient faces of maximal dimension are denoted Full Dimensional Efficient Facets (FDEFs). The identification of such strongly efficient facets is facilitated by removing all inefficient and all strongly efficient but not extreme efficient DMUs from the estimation procedure of the technology set. Any face that i) is passing through the origin and with (s + m − 1) linear independent extreme efficient observed DMUs positioned on it and ii) with a normal vector with strict positive (strict negative) output (input) components, is a FDEF, where s (m) is the number of outputs (inputs). It is, however, not correct that every face that satisfies only i) is a FDEF. We denote a face (a subface) that satisfies only condition i) but not condition ii) for an AP-face (an AP-subface). It is proved that a radial projection of any output input combination in the estimated EXFA technology set is positioned on the strongly efficient frontier if and only if i) no AP-(sub)faces exist, ii) a regulaty condition RC1 is satisfied and only dual multiplier constraints corresponding to extreme efficient DMUs are included in the estimation. A test for the fulfillment of the condition that no AP-(sub)faces exist is provided.