bluuebunny/crossref_metadata_2025_split huggingface dataset:
The First Saint Petersburg Regional Inflammatory Bowel Diseases Registry on the Basis of the Regional Health Information System: Principles of Functioning, Testing Results, Plan of Development
Authors: Uspenskiy Yu. P. , Sarana A. M. , Melentyeva L. N. , Yazenok A. V. , Petrov S. V. , Fominykh Yu. A. , Ivanov S. V. , Shotik A. V. , Segal A. M. , Gorbacheva T. V. , Plotnikova S. D. , Dronov K. V. 
Published: November 2023

Aim: to present the principles of functioning of the regional registry of inflammatory bowel disease (IBD) patients in Saint Petersburg on the basis of the City Health Information System (Saint Petersburg IBD Registry).Key points. The Saint Petersburg IBD Registry consists of General Statistical Module and Clinical Module. The General Statistical Module is intended to analyze the prevalence of ulcerative colitis and Crohn's disease, the number of patient visits to medical institutions; to assess the burden on the healthcare system, demographic characteristics, routing and mortality for the whole region. The Clinical Module allows to assess the IBD features in prospective observation. The register case report form is integrated into the patient's status in the Medical Information System of the medical institution. Saint Petersburg IBD Registry operates on the basis of the Saint Petersburg Medical Center of Information and Analysis within the framework of the Regional Medical Data Collection System of the Russian state information system “Regional Fragment of the Unified State Information System in the Healthcare Branch”. The accumulation of prospective data in the Clinical Module continues, which in the near future will make it possible to test and configure the automated analytical block of the registry.Conclusion. The functioning of the Saint Petersburg IBD Registry allows to achieve following primary goals within region: assessment of the epidemiological features of IBD in Saint Petersburg; dynamic assessment of the disease features; assessment and planning of health care resources required to provide care to IBD patients; improvement of approaches to the treatment taking into account the specifics of the region; assessment of the effectiveness and tolerability of specific treatment including biologics.
Penyuluhan perkembangan dan tantangan peserta didik usia pendidikan dasar pada Abad 21
Authors: Acesta Arrofa 
Published: November 2023

Pendidikan yang mampu mendukung pembangunan di masa mendatang adalah pendidikan yang mampu mengembangkan potensi setiap peserta didik. Untuk dapat mengembangkan potensi peserta didik guru harus memahami perkembangan peserta didik. Hal ini disebabkan karena setiap tahapan perkembangan manusia mempunyai karakteristik yang khas dan tugas-tugas perkembangan tersendiri. Tugas-tugas perkembangan tersebut juga sangat berhubungan dengan seberapa jauh pendidikan yang dapat diterima oleh individu. Melihat hal ini maka sangatlah penting pelaksanan pendidikan mempertimbangkan perkembangan peserta didik. Maka muncul pertanyaan apakah guru sudah memahami perkembangan peserta didik dan tantangan yang dihadapi dalam pendidikan abad 21. Berdasarkan hasil wawancara dengan Kepala Sekolah Satu Atap Cimulya diketahui bahwa sebagian besar guru masih membutuhkan pengetahuan mengenai perkembangan peserta didik dan tantangan yang dihadapi dalam pendidikan abad 21. Kondisi ini tentunya perlu ditanggapi guna meningkatkan profesionalisme guru. Hal ini yang mejadikan landasan dalam melaksanakan “Penyuluhan Perkembangan Peserta Didik Dan Tantangan Yang Dihadapi Peserta Didik Usia Pendidikan Dasar Pada Abad 21 di Sekolah Satu Atap Cimulya, Kecamatan Cimahi, Kabupaten Kuningan”. Tujuan dari pengabdian ini adalah: untuk 1) memberikan pemahaman terhadap guru mengenai perkembangan peserta didik, 2) memberikan pengetahuan tantangan peserta didik pada usia pendidikan dasar pada pendidikan abad 21. Metode yang digunakan adalah Penyuluhan penyampaian materi(ekspositori) dan diskusi
Kata Kunci: Penyuluhan;peserta didik;abad 21.
Regenerative potential and clinical application of mesenchymal stem cell-derived exosomes (review)
Authors:   Biotechnology Laboratory, Medical Company “Good Cells”, Kyiv, Ukraine, Gordiienko Inna , Shamshur Maryna ,   R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine,   Institute of Genetic and Regenerative Medicine, M. D. Strazhesko National Scientific Center of Cardiology, Clinical and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Novikova Svitlana , Zlatskiy Igor , Zlatska Alona 
Published: November 2023

For more than 50 years, mesenchymal stem cells have been extensively studied as a therapeutic agent in the treatment of various diseases. It became clear that MSC-derived secretome including the growth factors, cytokines, microvesicles and exosomes are the major drivers in the realization of beneficial effect of MSC-based therapy. Exosomes play an important role in the organism homeostasis and diseases development working as a vehicle for the transfer of the signaling and regulatory molecules between cells. Exosomes size, stability, cargo content that reflect the physiological state of parent cells make them an attractive new tool for regenerative medicine. Cell-free therapy or cell therapy 2.0 are being developed. Here, we review the molecular profile of exosomes derived from different MSC sources and their biological properties, the results of clinical application of MSC-derived exosomes in the of treatment COVID-19, alopecia, skin aging and osteoarthritis, discuss what issues exist in the development and application of a new biomedical product.	The purpose of this study was to analyze the literature data on the regenerative potential and clinical application of exosomes derived from mesenchymal stem cells.	Materials and methods. An analytical review of literature data was conducted using the information analysis of Medline (PubMed), Web of Science and Scopus databases, Google Scholar and the Cochrane Central Register of Controlled Trials (CENTRAL) and other sources until 2022 inclusive using the keywords: «exosomes», «mesenchymal stem cells», «cell-free therapy», «secretome», «miRNA»	Results. In this review, we consider the molecular profile of exosomes derived from different MSC sources and their biological properties, the results of clinical application of MSC-derived exosomes in the treatment of COVID-19, alopecia, skin aging and osteoarthritis, discuss what issues exist in the development and application of a new biomedical product.	Conclusion. The study, research and development of biotechnological products based on exosomes from different stem cell types are new stages in the development of regenerative medicine. Understanding the unique biological properties of MSCs derived from various tissue sources is one of the keys to develop effective exosomes-based biotechnological products to address specific medical goals.
Uptake of doublet therapy for de novo metastatic castration sensitive prostate cancer: a population-based drug utilisation study in Sweden
Authors: Gedeborg Rolf , Sandin Fredrik , Thellenberg-Karlsson Camilla , Styrke Johan , Franck Lissbrant Ingela , Garmo Hans , Stattin Pär 
Published: November 2023

Background: Randomised controlled trials have demonstrated prolonged survival with new upfront treatments in addition to standard androgen deprivation therapy (ADT) in men with de novo metastatic castration-sensitive prostate cancer. We describe patient characteristics, time trends and regional differences in uptake of these new treatment strategies in clinical practice.
Material and methods: This descriptive study consisted of men registered in the National Prostate Cancer Register of Sweden from 1 January 2018 to 31 March 2022 with de novo metastatic castration-sensitive prostate cancer defined by the presence of metastases on imaging at the time of diagnosis. Life expectancy was calculated based on age, Charlson Comorbidity Index and a Drug Comorbidity Index.
Results: Within 6 months from diagnosis, 57% (1,677/2,959) of men with de novo metastatic castration-sensitive prostate cancer and more than 3 years of life expectancy had received docetaxel, abiraterone, enzalutamide, apalutamide and/or radiotherapy. Over time, there was a 2-fold increase in uptake of any added treatment, mainly driven by a 6-fold increase in use of abiraterone, enzalutamide or apalutamide, with little change in use of other treatments.
Conclusions: Slightly more than half of men diagnosed with de novo metastatic castration-sensitive prostate cancer and a life expectancy of at least 3 years received additions to standard ADT as recommended by national guidelines in 2019–2022 in Sweden. There was a 2-fold increase in use of these treatments during the study period; however, efforts to further increase adherence to guidelines are warranted.
COUNTRY-SPECIFIC INVESTOR ATTENTION AND ADR MISPRICING
Authors: Gutierrez Juan , Perez Daniel , Vianna Andre 
Published: November 2023

This paper examines the effect of country-specific investor attention on ADR mispricing. Investor attention is measured by the amount of traffic a country’s Wikipedia profile page receives. A two-stage least squares (2SLS) regression is employed to examine the relationship between investor attention and ADR mispricing, but also to mitigate endogeneity between the two variables of interest. We use the FIFA World Ranking (country soccer ranking) and the number of UNESCO heritage sites as instruments for investor attention; given the unlikelihood that either of those variables can be caused by ADR mispricing. Our results show that lower levels of investor attention lead to higher ADR mispricing, therefore leading to a greater divergence of the law of one price for the sample of ADRs. The results are robust across various model specifications and to well-known determinants of mispricing such as turnover, stock prices, exchange rates, and market capitalization.
SOCIAL PROJECTS AS A TOOL FOR IMPLEMENTING INNOVATIONS IN SOCIAL WORK
Authors: Kolomiets Olena , Demydenko Tetyana 
Published: November 2023

The political and socio-economic situation in the country calls for a rapid response to address social issues through the implementation of innovations in the work of professionals in the social sphere of both the public and private sectors. The aim of the research is to analyze social projects as innovative tools for solving or minimizing social issues in social work. To achieve the research objective, the following methods were used: analysis and synthesis of scientific resources to investigate types of social innovations and the characteristics of internal innovations (social projects) as tools of innovative activity in social work. External (managerial, radical) and internal innovations (social projects) have been characterized, with the advantages of the latter identified: rapid response to situations, specificity, consideration of the characteristics and interests of individuals, groups, and communities, and the ability to more easily implement their own innovations compared to those proposed by others. The article presents classifications of social project ideas based on the criterion of novelty (absolute and relative novelty). It also discusses ways to develop a project after funding has ceased: using the implemented idea in the form of innovative material or ideal products (event scenarios, games, methodologies, technologies, social advertising, etc.) in further activities; error correction and improvement of the idea (project), developing a new project based on the modified idea; diffusion of the project idea into other areas; and the search for fundamentally new ideas and solutions for the development of new social projects. Emphasis is made on the fact that during the years of Ukraineʼs independence, a large number of social projects have been implemented by both government and non-governmental organizations in the field of social work. These projects contain a wealth of innovative ideas, original developments, and innovative products that can be partially or fully transformed and adapted to new conditions. Today, there is a necessity to develop a resource (platform) where innovators can consciously share their ideas and products for free, enabling individuals with active civic positions to unite for collaborative solutions to social problems in the country.
FOREIGN EXPERIENCE OF TEACHING STAFF QUALIFICATION IMPROVING
Authors: Malyar Lyubov , Milyan Zhanna 
Published: November 2023

The article is devoted to the problem of training teaching staff in the USA. It is noted that today in the USA considerable attention is paid not only to the training of teaching staff, but also to the improvement of their qualifications in the postgraduate education system. The purpose of the article is to reveal the features of professional development of teaching staff in the US postgraduate education system. Research methods: study of American scientific literature, analysis, systematization, concretization, generalization of the obtained data. Improving the qualifications of teaching staff is coordinated by the relevant bodies of the country. Thus, the Ministry of Education is a state body responsible for the implementation of government policy in the country on a wide range of issues in the field of education. Its composition, along with other subdivisions, includes: the National Center for Education Statistics, the National Council of Pedagogical Research, the National Institute of Education, the Department of Education, the Fund for the Improvement of Higher Education, the Bureau of Professional Development of Pedagogical Personnel. The main unit dealing with issues of retraining and professional development of teaching personnel in the USA is the Bureau of Professional Development of Pedagogical Personnel. The Bureau is headed by a chairman appointed by the Minister of Education of the country, usually from among specialists in the field of higher education who have an impeccable reputation and extensive experience of practical work in this field. In addition to the Ministry of Education and the Bureau of Professional Development, which reports to it, there are other federal state and public institutions that deal with problems of professional development, but they are not subordinate to the Ministry of Education. The study of scientific sources makes it possible to formulate the main principles on which the system of improving the qualifications of teachers in the USA is built today and will, according to the leaders of educational policy, be built in the future: continuity; focus on the variety of forms and technologies of professional development and personal development; participation of various categories of teaching staff in determining policy in the field of professional development; unification of all parties interested in the professionalism of teachers; recognizing the priority of education and increasing the prestige of the teaching profession in society; relationship between the system of professional development and the system of pedagogical education; focus on the optimal combination of special subject knowledge with professional and pedagogical knowledge and skills; professionalism, competence; focus on the use of research methods for improving the qualifications of teachers, on the development of their creative potential and initiative.
Review: Bentuk Sediaan dari Bahan Alam sebagai Suplemen Nutrisi dalam Pencegahan Stunting
Authors: Rahmah Raisya , Nur Hasanah Aliya 
Published: November 2023

Stunting merupakan suatu keadaan dimana terjadi gangguan pertumbuhan anak yang tidak sesuai dengan usianya. Tercatat pada tahun 2022 angka stunting di Indonesia mencapai 21,6 %. Upaya pada pencegahan terhadap stunting salah satunya dengan pemberian suplemen nutrisi baik dalam bentuk sintetik maupun herbal. Suplemen nutrisi untuk pencegahan stunting di Indonesia sudah banyak diteliti dan beredar luas. Pemberian suplemen herbal beredar dalam berbagai bentuk sediaan diantaranya gummy candies, serbuk, tablet, sirup, suspensi,dan emulsi. Sampai saat ini belum pernah ada artikel yang mengulas berbagai bentuk sediaan yang dibuat untuk penunjang nutrisi tersebut. Artikel ini dibuat dengan tujuan memperoleh bentuk – bentuk sediaan dari natural resources sebagai suplemen nutrisi untuk mengoptimalkan upaya peningkatan nutrisi menjadi lebih efektif dan efisien. Artikel ulasan dilakukan dengan mencari artikel berkaitan yang diterbitkan 10 tahun terakhir dengan bantuan situs pencarian jurnal online yaitu Google Scholar dan Scopus menggunakan kata kunci “formulasi sediaan obat untuk stunting” “drug formulation for stunting” dan “natural resources drug for stunting”. Dari hasil tersebut didapatkan 12 artikel yang sesuai dengan tujuan penelitian yang terdiri dari beberapa bentuk sediaan obat menggunakan natural resources sebagai zat aktifnya. Berdasarkan penelusuran, bentuk sediaan serbuk tidak terbagi paling banyak digunakan dengan daun kelor dan rimpang temulawak sebagai bahan alam yang banyak dibuat menjadi sediaan untuk pencegahan stunting. Kedepannya diharapkan lebih banyak eksplorasi terkait natural resources yang dapat dimanfaatkan untuk stunting karena sampai saat ini penelitian tersebut masih sangat terbatas.
Unlocking the secrets of Spain’s R&D subsidies: An advanced analysis of applicant companies
Authors: Espinosa-Blasco Mónica , Penagos-Londoño Gabriel I. , Ruiz-Moreno Felipe , Vilaplana-Aparicio María J. 
Published: November 2023

Abstract
Innovation is crucial for companies to stay competitive, provide value to customers, and generate profits. Likewise, research and development (R&D) is critical for companies to sustain productivity growth. Spain has lagged behind other countries in terms of R&D investment, with only 1.4% of its GDP allocated to R&D, well below the European average. To improve this situation, the government offers subsidies to stimulate R&D in Spanish companies. This study examines the profile of subsidized companies in Spain. The aim is to provide insight into the support for companies that apply for innovation subsidies by analyzing the profile of subsidized companies and identifying key variables influencing the success of obtaining innovation grants. The study is based on advanced estimation methods. Natural language processing (NLP), artificial neural network (ANN) techniques, and clustering are used to perform rigorous and robust analysis of the profile of subsidized companies in Spain. The study thus contributes to knowledge in the field of innovation subsidies
Ochratoxin A and Aflatoxin B1 as Factors of Bone Damage and Neurodegeneration Through the Influence on the Immunomodulation Processes of TNF-α and IL-6 Concentrations
Authors: Radzka-Pogoda Agnieszka , Radzki Radosław Piotr , Bieńko Marek , Szponar Jarosław , Sokołowska Barbara , Kulik Anna , Lewicka Małgorzata , Borzęcki Andrzej 
Published: November 2023

Abstract
The wide distribution of mycotoxins, including aflatoxin B1 and ochratoxin A, in the environment and their influence on living organisms make them an interesting research problem. Numerous complications of intoxication with these substances are known, however, particular attention is paid to the effects on the skeletal and nervous systems. The inflammatory effect, presented by the increase in the concentration of cytokines - IL-6 and TNF-α may influence the immune dysregulation present in bone metabolism disorders, as well as in neurodegeneration. Mycotoxins also contribute to osteodegeneration by modifying vitamin D metabolism. Interestingly, and still unexplored, is the mechanism of intrauterine influence on bone metabolism and neurodegeneration processes. Understanding the above mechanisms may help in monitoring the toxic effects of intoxication with these toxins. It can also help develop methods of therapy for poisoning with this compound, in animals and humans.
MLPA in the initial genetic screening of patients with acute myeloid leukemia
Authors: Yahya Dinnar , Hachmeriyan Mari , Ruseva Tsanka , Chervenkov Trifon , Micheva Ilina 
Published: November 2023

Abstract

Introduction:
This study aimed to assess the effectiveness of multiplex ligase-dependent probe amplification (MLPA) in the initial genetic screening of patients with acute myeloid leukemia (AML) since current risk stratification and clinical management depend on molecular-genetic markers.

Methods:
We performed a prospective case-control study on newly diagnosed patients from the Clinical hematology clinic of UMHAT “St. Marina”, Varna, for the period 02.2022 – 02.2023. MLPA – a semiquantitative PCR-based method, was implemented with probes for 40 AML/myelodysplastic syndrome-typical genetic changes. We compared these findings with a parallelly carried out cytogenetic analysis, part of the routine diagnostic process.

Results:
We assessed 61 patients – 29 females and 32 males, median age of 61 years for females and 65 for males (min-max 20-89). 34 (56%) of all showed pathological results, while the rest 27 (44%) did not. Of the 34, 22 (65%) had a single gene variant in genes NPM1, DNMT3A, FLT3, and IDH2, isolated or in combination. 18 (53%) of the same 34 also had copy number aberration (CNA) in chromosomes 4, 5, 6, 7, 11, 14, 17, and 21. The latter were either isolated or in combination with other findings. 8 of the 18 cases also underwent cytogenetic analysis, with concordance between the two methods in 4.

Conclusion:
MLPA is an informative method for initial genetic assessment in addition to cytogenetic analysis. Still, more patients are needed to draw finite conclusions on its eligibility for routine use. Given the significant percentage of normal results – 44%, simultaneous evaluation of more genetic markers, included in current guidelines, is reasonable.