bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of diabetes mellitus on the respiratory function of amyotrophic lateral sclerosis patients
Authors: Pinto Susana , Oliveira Santos Miguel , Gromicho Marta , Swash Michael , de Carvalho Mamede 
Published: November 2023

AbstractBackground and purposeRespiratory insufficiency and its complications are the main cause of death in amyotrophic lateral sclerosis (ALS). The impact of diabetes mellitus (DM) on respiratory function of ALS patients is uncertain.MethodsA retrospective cohort study was carried out. From the 1710 patients with motor neuron disease followed in our unit, ALS and progressive muscular atrophy patients were included. We recorded demographic characteristics, functional ALS rating scale (Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised [ALSFRS‐R]) and its subscores at first visit, respiratory function tests, arterial blood gases, phrenic nerve amplitude (PhrenAmpl), and mean nocturnal oxygen saturation (SpO2mean). We excluded patients with other relevant diseases. Two subgroups were analysed: DIAB (patients with DM) and noDIAB (patients without DM). Independent t‐test, χ2, or Fisher exact test was applied. Binomial logistic regression analyses assessed DM effects. Kaplan–Meier analysis assessed survival. p < 0.05 was considered significant.ResultsWe included 1639 patients (922 men, mean onset age = 62.5 ± 12.6 years, mean disease duration = 18.1 ± 22.0 months). Mean survival was 43.3 ± 40.7 months. More men had DM (p = 0.021). Disease duration was similar between groups (p = 0.063). Time to noninvasive ventilation (NIV) was shorter in DIAB (p = 0.004); total survival was similar. No differences were seen for ALSFRS‐R or its decay rate. At entry, DIAB patients were older (p < 0.001), with lower forced vital capacity (p = 0.001), arterial oxygen pressure (p = 0.01), PhrenAmpl (p < 0.001), and SpO2mean (p = 0.014).ConclusionsALS patients with DM had increased risk of respiratory impairment and should be closely monitored. Early NIV allowed for similar survival rate between groups.
Core competencies of emergency nurses for the armed conflict context: Experiences from the field
Authors: Mani Zakaria A. , Kuhn Lisa , Plummer Virginia 
Published: November 2023

AbstractBackgroundArmed conflicts are usually associated with high mortality and morbidity rates, with unpredictable workload, injuries and illnesses. Identifying emergency nurses’ views of the core competencies required to enable them to work effectively in hospitals in areas of armed conflict is critical. It is important to inform the requisite standards of care and facilitate the translation of knowledge into safe, quality care.AimThe aim of this study was to identify emergency nurses’ perceptions of core competencies necessary to work in hospitals in the context of armed conflict.MethodA descriptive qualitative phase of a mixed‐method study using semi‐structured interviews with participants was conducted from June to July 2019. The COREQ guideline for reporting qualitative research was followed.FindingsA sample of 15 participants was interviewed. The participant perceptions provided a different perspective of core competencies required for emergency nurses in the context of armed conflict, culminating in four main areas: (i) personal preparedness , (ii) leadership, (iii) communication and (iv) assessment and intervention.ConclusionThis study identified emergency nurses’ perceptions of their core competencies. Personal preparedness, leadership, communication, assessment and intervention were identified as contributing to calmness of character, confidence in care and cultural awareness for care in this setting and were essential for them to work effectively when managing victims of armed conflict in emergency departments.Implications for nursing practice and health policyThe findings of this study are important and novel because the researchers sought the perspectives of emergency nurses who have experience in receiving patients from armed conflict firsthand. The findings will inform policymakers in those settings regarding standard of care, education and drills for hospital nurses in optimizing armed conflict care response outcomes.
Infestation intensity by the invasive oak lace bug, Corythucha arcuata (Say) in mixed and pure oak stands
Authors: Hoch Gernot , Stemmelen Alex , Eötvös Csaba Béla , Hinterstoisser Werner , Lanšćak Miran , Stojnić Srđan , Tóth Máté , Westergren Marjana , Zidar Simon , Zlatković Milica , Zoric Nikola , de Groot Maarten 
Published: November 2023

AbstractThere has been accumulating evidence for effects of tree species composition on herbivory with many examples of lower damage by specialist feeders in tree species rich forests. In a joint study in five Central and Southeastern European countries, we studied the effect of tree species richness on infestation intensity of the oak lace bug, Corythucha arcuata (Say) (Heteroptera, Tingidae), an invasive pest on oak trees that has spread rapidly across the Balkan Peninsula and Central Europe. Intensity of infestation by C. arcuata on oaks was assessed on three or four study plots with high (pure stands) and three or four plots with low percentage of oak (mixed stands) in each country. Ordinal regression analysis showed that intensity of infestation of trees by C. arcuata differed between countries; no significant effect of stand type (mixed or pure) on infestation levels was detected. When analysing the percentage of trees in the highest infestation class, stand type had a significant effect with more intensive infestation in pure stands. We conclude that mixed stands will not prevent severe infestation but may help mitigating the impact of established C. arcuata populations.
Effects of mindfulness‐based interventions on reducing psychological distress among nurses: A systematic review and meta‐analysis of randomized controlled trials
Authors: Karo Mestiana , Simorangkir Lindawati , Daryanti Saragih Ita , Suarilah Ira , Tzeng Huey‐Ming 
Published: November 2023

AbstractPurposeNurses increasingly use mindfulness as an effective mental health intervention to reduce psychological distress. The effectiveness of mindfulness‐based interventions remains inconclusive, which may lead to implementation of interventions in an inefficient or ineffective manner. This study aimed to examine the effects of mindfulness‐based interventions on reducing stress, anxiety, and depression among nurses.DesignSystematic review and meta‐analysis.MethodsRandomized controlled trials (RCTs) were searched using six databases published through May 20, 2023, which evaluated the effects of mindfulness‐based interventions on reducing psychological distress among nurses. To assess the quality of methodology included in the RCTs, version 2 of the Cochrane risk‐of‐bias instrument for RCTs with five domains was used. Standardized mean difference (SMD) with 95% confidence interval (CI) were calculated using the random–effects model in the meta‐analyses. Publication bias was assessed using Egger's regression test. Further, the robustness effect size of the pooled analysis was assessed using leave‐one‐out sensitivity analysis.FindingsA total of 16 RCTs were included in the final analysis. Overall, the modalities appeared to alleviate stress (pooled SMD: −0.50 [95% CI: −0.82 to −0.18]; p < 0.001) and depression (pooled SMD: −0.42 [95% CI: −0.78 to −0.06]; p = 0.02) among nurses.ConclusionMindfulness‐based interventions appear to alleviate stress and depression in nurses. Future research evaluating mindfulness‐based interventions among working nurses with more rigorous methodological and larger sample size.Clinical RelevanceSupport for nurses' mental health must be included while implementing personal and professional development plans.
Nurse experiences of partnership nursing when caring for children with long‐term conditions and their families: A qualitative systematic review
Authors: Barratt Macey , Bail Kasia , Lewis Peter , Paterson Catherine 
Published: November 2023

AbstractAimTo explore the experiences of partnership nursing among nurses when caring for children and young people with long‐term conditions, and their families.BackgroundPartnership nursing is promoted as a positive model of care among paediatric nurses, where shared roles and decision‐making, parental participation, mutual trust and respect, communication and negotiation are valued to create positive care experiences and enhance patient outcomes. Little is known about how nurses use partnership with both the patient and the parents in this triad to deliver partnership nursing.DesignA qualitative systematic review followed Joanna Briggs Institute meta‐aggregation approach and has been reported according to PRISMA guidelines.MethodsA comprehensive systematic search was conducted in seven electronic databases. Studies were assessed according to a pre‐determined inclusion criteria. Qualitative findings with illustrative participant quotes were extracted from included studies and grouped into categories to inform overall synthesised findings. Methodological quality assessment was conducted.FindingsA total of 5837 publications were screened, and 41 qualitative studies were included. Three overarching synthesised findings were identified: (1) Using education to promote feelings of safety and support, (2) Partnering to develop a strong therapeutic relationship and (3) Optimising communication underpinned by shared decision‐making principles to deliver individualised care.ConclusionNurses demonstrated successful partnership in their practice, but focused on developing dyadic nurse–parent and dyadic nurse–child partnerships. Future practice development that creates a three‐way triadic partnership may aid therapeutic relationships and shared decision‐making.Implications for clinical practiceClinicians can reflect on how dyadic partnerships (focusing on the child or the parent) may exclude opportunities for coherent care. Further exploration in practice, policy and research as to how nurses determine child competency and child and parent level of engagement in triadic partnership may improve the potential of meaningful shared decision‐making.
Splenectomy outcomes in immune cytopenias: Treatment outcomes and determinants of response
Authors: Ogbue Olisaemeka D. , Bahaj Waled , Kewan Tariq , Ahmed Ramsha , Dima Danai , Willimas Nakisha , Durmaz Arda , Visconte Valeria , Maskal Sara M. , Gurnari Carmelo , Steven Rosenblatt , Maciejewski Jaroslaw P. 
Published: November 2023

AbstractBackgroundSplenectomy is commonly used to treat refractory immune–mediated cytopenia, but there are no established factors that are associated with response to the procedure.ObjectivesA cohort study was conducted to evaluate the hematologic and surgical outcomes of splenectomy in adult patients with immune cytopenias and identify preoperative factors associated with response.MethodsData from the Cleveland Clinic Foundation for 1824 patients aged over 18 who underwent splenectomy from 2002 to 2020 were analyzed.ResultsThe study found that the most common indications for splenectomy were immune thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia, with a median age of 55 years and median time from diagnosis to splenectomy of 11 months. Hematologic response rates were 74% overall, with relapse in 12% of cases. Postsplenectomy discordant diagnoses were present in 13% of patients, associated with higher relapse rates. Surgery‐related complications occurred in 12% of cases, whereas only 3% of patients died from disease complications. On univariate analysis, preoperative factors associated with splenectomy treatment failure were ≥3 lines of pharmacologic treatment, whereas isolated thrombocytopenia, primary ITP, and age ≤40 years had a strong association with response. The multivariable regression confirmed that treatment failure with multiple lines of medical therapy was associated with the failure to respond to splenectomy.ConclusionOverall, the study demonstrates that splenectomy is an effective treatment option for immune‐mediated cytopenias with a low complication rate.
Team conflict at the core: Exploring the influence of critical team member conflict on team creative functioning
Authors: Liao Huiyao , Harris T. Brad , Li Ning , Han Yuqing 
Published: November 2023

AbstractScholars have long been intrigued by the relationship between intrateam conflict and team creativity, though findings to date have been mixed. Recent research suggests that traditional conceptualizations of intrateam conflict as a property that is shared uniformly by team members (e.g., averaging members' overall conflict perceptions), rather than a more nuanced phenomenon between individual members with unique network positions, have limited our understanding of its influences. These advances, however, have yet to be substantively applied to the intrateam conflict‐creativity literature. Accordingly, we integrate network views of conflict with creativity theory and group motivated processing models to explore how task and relationship conflicts involving critical members' (i.e., members central to a team's workflow network) influence team creative functioning beyond overall conflict perceptions. We theorize that critical member task conflict is positively associated with team creativity by way of team reflexivity, and this positive indirect effect is accentuated by team shared goals. Further, we posit that critical member relationship conflict is negatively associated with team creativity by way of reduced team cohesion, though this effect is mitigated by critical member emotional intelligence. Analyses of 70 new product development teams support most hypotheses while also highlighting interesting nuance and future research opportunities.
Can a cup a day keep cancer away?Asystematic review exploring the potential of coffee constituents in preventing oral squamous cell carcinoma
Authors: Deng Jonathan , Misra Vaidehi , Vilash Neehal , Wu Wendi , Hua Cindy , Son Kate , Canfora Federica , Kong Fabian Y. S. , Paolini Rita , McCullough Michael , Celentano Antonio 
Published: November 2023

AbstractBackgroundCoffee is one of the most consumed beverages in the world. Containing an abundance of bioactive molecules including polyphenols and flavonoids, the constituents of this beverage may exert antiproliferative, antioxidant and anti‐inflammatory effects.MethodsWe conducted a systematic review to summarise the available evidence on the anticancer effects of coffee constituents and their potential therapeutic use for oral squamous cell carcinoma (OSCC). Studies were identified through a comprehensive search of OVID MEDLINE, OVID EMBASE and Web of Science, including articles from any year up to 15 May 2023.ResultsOf the 60 reviewed papers, 45 were in vitro, 1 was in silico and 8 were in vivo exclusively. The remaining studies combined elements of more than one study type. A total of 55 studies demonstrated anti‐proliferative effects, whilst 12 studies also investigated migration and invasion of neoplastic cells. The constituents studied most frequently were quercetin and epigallocatechin gallate (EGCG), demonstrating various cytotoxic effects whilst also influencing apoptotic mechanisms in cancer cell lines. Dose‐dependent responses were consistently found amongst the studied constituents.ConclusionWhilst there was heterogeneity of study models and methods, consistent use of specific models such as SCC25 for in vitro studies and golden hamsters for in vivo studies enabled relative comparability. The constituents of coffee have gained significant interest over the last 30 years, particularly in the last decade, and present an area of interest with significant public health implications. Currently, there is a paucity of literature on utilization of active coffee constituents for the therapeutic treatment of oral cancers.
Positional accuracy during the sequence of static computer‐assisted implant surgery in three alveolar ridge morphologies: An in vitro study
Authors: Raabe Clemens , Abou‐Ayash Samir , Yilmaz Burak , Surbek Fiona Jennifer , Chappuis Vivianne , Couso‐Queiruga Emilio 
Published: November 2023

AbstractPurposeThis in vitro study aimed to assess the positional accuracy during the sequence of static computer‐assisted implant surgery (sCAIS) according to the anatomical characteristics of the alveolar ridge.Material and MethodsMaxillary bone models with six single tooth gaps including clinical scenarios of healed alveolar ridge (HR), single‐rooted (SRS), and three‐rooted socket (TRS) morphologies were used in this study. Positional deviations during implant placement procedures were evaluated after the pilot osteotomy (PD), final osteotomy (FD), and implant placement with respect to the pre‐planned implant position by using a software package. ANOVA and post hoc analyses were performed.ResultsA total of 90 implants were included in this study. Higher mean angular, crestal, and apical deviations were found after the PD and FD (3.5 ± 2.4°, 0.7 ± 0.3 mm, and 1.4 ± 0.8 mm versus 3.6 ±2.2°, 0.6 ± 0.3 mm, and 1.2 ± 0.6 mm) compared to IP (2.8 ± 1.6°, 0.7 ± 0.3 mm, and 1.2 ± 0.5 mm, p ≤ 0.004). Implants placed in TRS demonstrated higher mean angular, crestal, and apical deviations (4.0 ± 1.7°, 0.8 ± 0.3 mm, and 1.6 ± 0.5 mm) compared to implants placed in SRS (2.5 ± 1.2°, 0.7 ± 0.3 mm, and 1.1 ± 0.4 mm) or HR (2.0 ± 0.9°, 0.5 ± 0.3 mm, and 0.8 ± 0.4 mm, p < 0.001).ConclusionsPositional deviations during sCAIS procedures are initiated with the first implant osteotomy and persist throughout the drilling sequence. However, deviations slightly decreased after implant placement. The alveolar ridge morphology is strongly associated with positional deviations. Higher deviations were observed in three‐rooted and single‐rooted sockets simulating an immediate approach compared to healed sites simulating a delayed protocol.
Putting the F into FBD analysis: tree constraints or morphological data?
Authors: Barido‐Sottani Joëlle , Pohle Alexander , De Baets Kenneth , Murdock Duncan , Warnock Rachel C. M. 
Published: November 2023

AbstractThe fossilized birth–death (FBD) process provides an ideal model for inferring phylogenies from both extant and fossil taxa. Using this approach, fossils are directly integrated into the tree, leading to a statistically coherent prior on divergence times. Since fossils are typically not associated with molecular sequences, additional information is required to place fossils in the tree. We use simulations to evaluate two different approaches to handling fossil placement in FBD analyses: using topological constraints, where the user specifies monophyletic clades based on established taxonomy, or using total‐evidence analyses, which use a morphological data matrix in addition to the molecular alignment. We also explore how rate variation in fossil recovery or diversification rates impacts these approaches. We find that the extant topology is well recovered under all methods of fossil placement. Divergence times are similarly well recovered across all methods, with the exception of constraints which contain errors. We see similar patterns in datasets which include rate variation, however, relative errors in extant divergence times increase when more variation is included in the dataset, for all approaches using topological constraints, and particularly for constraints with errors. Finally, we show that trees recovered under the FBD model are more accurate than those estimated using non‐time calibrated inference. Overall, we show that both fossil placement approaches are reliable even when including uncertainty. Our results underscore the importance of core taxonomic research, including morphological data collection and species descriptions, irrespective of the approach to handling phylogenetic uncertainty using the FBD process.
Do diverse wheat genotypes unleash their biochemical arsenal differentially to conquer cold stress? A comprehensive study in the Western Himalayas
Authors: Jan Sofora , Kumar Sandeep , Yousuf Munaza , Shafi Safoora , Majid Ronak , Khan M. Anwar , Jeelani Fehim , Shikari Asif Bashir , Kaur Satinder , Kumar Sundeep , Kalia Sanjay , Singh Kuldeep , Prasad Manoj , Varshney Rajeev K. , Mir Reyazul Rouf 
Published: November 2023

AbstractWheat is one of the most important cereal crops in the world. Cold stress is a major constraint in production of wheat grown in cold climate regions. In this study, we conducted a comprehensive assessment of cold stress tolerance in wheat genotypes through field screening, cell membrane stability through electrolyte leakage assay and biochemical profiling. A core set comprising 4560 genotypes was evaluated for two years (2021–2022), revealing substantial genetic variation for cold stress tolerance. Most genotypes exhibited moderate tolerance, while a smaller proportion showed susceptibility to cold stress. Based on the cold screening data in the field, a mini‐core set of 350 genotypes was selected for membrane stability analysis using electrical conductivity assays. Significant differences were observed in membrane stability among the genotypes, indicating the presence of genetic variation for this trait. Furthermore, a mini‐core set was narrowed down to 50 diverse candidate genotypes that were subsequently profiled for various biochemicals, including reactive oxygen species (ROS) like lipid peroxidation (MDA) and hydrogen peroxide (H202), osmoprotectant (proline) and enzymatic antioxidants including ascorbate peroxidase (APX), superoxide dismutase (SOD), guaiacol peroxidase (GPX), and catalase (CAT). Correlation analysis of the biochemicals revealed negative associations between antioxidants and reactive oxygen species (ROS), highlighting their role in mitigating oxidative damage under cold stress. This study enhances our understanding of the physiological and biochemical mechanisms underlying cold stress tolerance in wheat. The identified genotypes with superior cold stress tolerance can serve as valuable genetic resources for wheat breeding.
Acquisition of Desiccation Tolerance Unveiled: Polar Lipid Profiles of Streptophyte Algae Offer Insights
Authors: Arzac Miren Irati , Miranda‐Apodaca Jon , Gasulla Francisco , Arce‐Guerrero María , Fernández‐Marín Beatriz , García‐Plazaola José Ignacio 
Published: November 2023

AbstractTerrestrialization by photosynthetic eukaryotes took place in the two branches of green microalgae: Chlorophyta and Charophyta. Within the latter, the paraphyletic streptophytic algae divide into two clades. These are named Klebsormidiophyceae‐Chlorokybophyceae‐Mesostigmatophyceae (KCM), which is the oldest, and Zygnematophyceae‐Coleochaetophyceae‐Charophyceae (ZCC), which contains the closest relatives of vascular plants. Terrestrialization required the emergence of adaptations in response to new challenges, such as irradiance, temperature oscillations and water deprivation. In this study, we evaluated lipid composition in species representative of distinct phylogenetic clusters within Charophyta and Chlorophyta. We aim to study whether the inherent thylakoid lipid composition, as well as its adaptability in response to desiccation, were fundamental factors for the evolutionary history of terrestrial plants. The results showed that the lipid composition was similar to that found in flowering land plants, differing only in betaine lipids. Likewise, the largest constitutive pool of oligogalactolipids (OGL) was found only in the fully desiccation‐tolerant species Klebsormidium nitens. After desiccation, the content of polar lipids decreased in all species. Conversely, the content of OGL increased, particularly trigalactosyldiacylglycerol and tetragalactosyldiacylglycerol in the ZCC clade. The analysis of the molecular species composition of the newly formed OGL may suggest a different biosynthetic route for the KCM and ZCC clades. We speculate that the appearance of a new OGL synthesis pathway, which eventually arose during the streptophyte evolutionary process, endowed algae with a much more dynamic regulation of thylakoid composition in response to stress, which ultimately contributed to the colonization of terrestrial habitats.