bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors promoting hunting groups’ sustainable harvest of moose in a co-management system
Authors: Tuominen Laura S. , Wikström Mikael , Helanterä Heikki , Karell Patrik , Pusenius Jyrki , Rapeli Lauri , Ruha Leena , Vuorisalo Timo , Brommer Jon E. 
Published: November 2023

AbstractCollaboration between and within management levels and involvement of local communities (co-management) increases sustainable management of natural resources. In Finland, moose (Alces alces) are harvested by hunting groups within a co-management system, providing meat and social benefits. We computed the 14-year change in moose harvest (2007–2020) for 4320 hunting groups. Moose harvest declined on average 1.1% per year, but with substantial variation in moose harvest changes between the hunting groups. We extracted information describing the collaboration between the hunting groups, their democratic status as well as leader dynamics, and the year of establishment. A hunting group’s moose harvest was more stable (i.e. declined less) when the hunting group was (1) established a longer time ago; (2), had more changes in leadership over time, but did not depend on collaboration with other local hunting groups (in terms of jointly holding moose hunting licenses), whether the hunting group was a registered society (presumed to be more democratic than a non-registered one) or had consecutive leaders that shared a surname (presumed to be related). We conclude that encouraging resource users’ early establishment in groups and groups’ long-term persistence and promoting democratic leadership roles improves stable benefits from a natural resource in a co-management system.
Correcting modification-mediated errors in nanopore sequencing by nucleotide demodification and reference-based correction
Authors: Chiou Chien-Shun , Chen Bo-Han , Wang You-Wun , Kuo Nang-Ting , Chang Chih-Hsiang , Huang Yao-Ting 
Published: November 2023

AbstractThe accuracy of Oxford Nanopore Technology (ONT) sequencing has significantly improved thanks to new flowcells, sequencing kits, and basecalling algorithms. However, novel modification types untrained in the basecalling models can seriously reduce the quality. Here we reports a set of ONT-sequenced genomes with unexpected low quality due to novel modification types. Demodification by whole-genome amplification significantly improved the quality but lost the epigenome. We also developed a reference-based method, Modpolish, for correcting modification-mediated errors while retaining the epigenome when a sufficient number of closely-related genomes is publicly available (default: top 20 genomes with at least 95% identity). Modpolish not only significantly improved the quality of in-house sequenced genomes but also public datasets sequenced by R9.4 and R10.4 (simplex). Our results suggested that novel modifications are prone to ONT systematic errors. Nevertheless, these errors are correctable by nucleotide demodification or Modpolish without prior knowledge of modifications.
The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging
Authors: Smith Lydia M. , Greenwood Hannah E. , Tyrrell Will E. , Edwards Richard S. , de Santis Vittorio , Baark Friedrich , Firth George , Tanc Muhammet , Terry Samantha Y. A. , Herrmann Anne , Southworth Richard , Witney Timothy H. 
Published: November 2023

AbstractMouse models are invaluable tools for radiotracer development and validation. They are, however, expensive, low throughput, and are constrained by animal welfare considerations. Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging studies. NCI-H460 FLuc cells grown in Matrigel on the CAM formed vascularized tumors of reproducible size without compromising embryo viability. By designing a simple method for vessel cannulation it was possible to perform dynamic PET imaging in ovo, producing high tumor-to-background signal for both 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and (4S)-4-(3-18F-fluoropropyl)-L-glutamate (18F-FSPG). The pattern of 18F-FDG tumor uptake were similar in ovo and in vivo, although tumor-associated radioactivity was higher in the CAM-grown tumors over the 60 min imaging time course. Additionally, 18F-FSPG provided an early marker of both treatment response to external beam radiotherapy and target inhibition in ovo. Overall, the CAM provided a low-cost alternative to tumor xenograft mouse models which may broaden access to PET and SPECT imaging and have utility across multiple applications.
Quelle place pour l’expérimentation en éthologie ?
Authors: Kreutzer Michel 
Published: November 2023

La démarche expérimentale est au centre de mes réflexions depuis mon baccalauréat « sciences ex ». Formé aux neurosciences, j’ai très vite choisi l’éthologie de terrain, pensant échapper à certaines démarches expérimentales et m’offrir des activités de recherche plus respectueuses de la vie animale. Aujourd’hui, je dois constater que cette option n’aboutit pas forcément à ce que j’avais imaginé. J’ai été à la fois le témoin et l’acteur de pratiques qui méritent attention. Ce parcours, jalonné par une évolution des conceptions de nos relations avec les être animés, me conduit à questionner les éthiques, parfois contradictoires, de l’action et de la connaissance.
Pour une bonne compréhension et un bon usage du terme « organoïdes »
Authors: Chneiweiss Hervé , Dubart-Kupperschmitt Anne , Duclos-Vallée Jean-Charles , Clément Bruno , Flacher Vincent , Galzi Jean-Luc , Gidrol Xavier , Goureau Olivier , Guasch Géraldine , Haiech Jacques , Lemaitre Christine , Mahé Maxime M. , Martin Sophie , Poulain Laurent , Sebastiani Corinne , Vergnolle Nathalie , Yates Frank 
Published: November 2023

Depuis une dizaine d’années, des progrès considérables ont été réalisés concernant les conditions qui permettent à des cellules de s’auto-organiser dans l’espace comme elles le font lors des phases précoces du développement embryonnaire ou dans certains tissus adultes. On nomme ainsi « organoïdes » des structures en trois dimensions complexes, organisées et intégrant plusieurs types cellulaires, qui peuvent reproduire in vitro certaines fonctions d’un organe. Toutefois, ces organoïdes ne peuvent actuellement reproduire à l’identique une architecture anatomique et fonctionnelle complète. Bien qu’utilisé pour des raisons de simplification pour la communication, en particulier dans la presse généraliste, il est donc abusif d’utiliser le terme « mini-organes » pour décrire ces structures.
Observation clinique : Hépatite par surcharge en cuivre chez un chien
Authors: Kaufmann Hugo , Da Riz Fiona , Benchekroun Ghita 
Published: November 2023

Un chien mâle entier croisé type Berger, âgé de 9 ans, est présenté en consultation pour dysorexie et amaigrissement évoluant depuis 6 mois. À l’examen clinique, un ictère franc et une cachexie sont mis en évidence. Les premiers examens complémentaires révèlent une hépatite chronique, avec une augmentation de l’activité des enzymes hépatiques, une hyperbilirubinémie et un foie hypoéchogène. Les recherches infectieuses et les cytoponctions de foie et de bile ne sont pas concluantes. Des biopsies hépatiques sous cœlioscopie sont alors réalisées. Leur analyse histologique et le dosage de cuivre conduisent au diagnostic d’hépatite cuprique. Un traitement à base de chélateur de cuivre (D-pénicillamine) et une alimentation pauvre en cuivre sont initiés, mais des complications liées à l’insuffisance hépatique amènent au décès de l’animal 4 mois après la présentation initiale. Ce cas clinique illustre que les surcharges hépatiques en cuivre ne surviennent pas que chez les races prédisposées (Bedlington terrier et Labrador en particulier). Des apports alimentaires excessifs en cuivre sont suspectés comme étant à l’origine de l’augmentation des cas d’hépatopathie cuprique ces dernières décennies. Le diagnostic, difficile, repose avant tout sur l’analyse histologique du parenchyme hépatique et le dosage du cuivre intra-hépatique.
Regulationsstörung beim Säugling – aktuelle Ergebnisse einer Behandlungsoption mit einem anthroposophischen Komplexarzneimittel
Authors: Gruber Kim , Stintzing Florian C. , Turek Claudia , Zilkowski Ilona , Mörbt Nora , Vögele Peter 
Published: November 2023

ZusammenfassungIn einer multizentrischen prospektiven nicht interventionellen Studie haben wir die Anwendung eines Komplexarzneimittels mit Extrakten aus Kümmel, Kamille, Tollkirsche und Tabak bei Säuglingen mit Bauchbeschwerden, Unruhezuständen sowie Schlafstörungen untersucht. Ziel war es, Daten zur Anwendung, Sicherheit, Verträglichkeit, zum Therapieverlauf und zur Akzeptanz der Behandlung zu erfassen. Hebammen, Kinderärzt*innen und Eltern dokumentierten die Behandlung von Säuglingen unter einem Jahr, die aufgrund der oben genannten Symptome das Arzneimittel Carum carvi comp. Säuglingszäpfchen (WALA Heilmittel GmbH, Bad Boll, Deutschland) erhielten. Vom ersten bis zum letzten Beobachtungstag gab es eine signifikante Reduktion der Beschwerden und der Schreidauer, während sich die Schlafdauer signifikant erhöhte. Therapieverlauf und Verträglichkeit wurden als „gut“ oder „sehr gut“ bewertet. Die Anwendung war sicher, führte zu einer Verringerung der Beschwerden und wurde mehrheitlich positiv bewertet.
Parenteral Fosfomycin in Gastrointestinal Surgery: A Systematic
Review
Authors: Fonnes Siv , Fonnes Masja Klindt , Holzknecht Barbara Juliane , Rosenberg Jacob 
Published: November 2023

Abstract
Background To investigate if perioperative parenteral administration of
fosfomycin given before or during gastrointestinal surgery could protect against
postoperative infectious complications and characterise the administration of
fosfomycin and its harms.
Methods This systematic review included original studies on
gastrointestinal surgery where parental administration of fosfomycin was given
before or during surgery to≥5 patients. We searched three databases on
March 24 2023 and registered the protocol before data extraction
(CRD42020201268). Risk of bias was assessed with Cochrane Handbook risk of bias
assessment tool or the Newcastle-Ottawa Scale. A narrative description was
undertaken. For infectious complications, results from emergency and elective
surgery were presented separately.
Results We included 15 unique studies, reporting on 1,029 patients that
received fosfomycin before or during gastrointestinal surgery. Almost half of
the studies were conducted in the 1980s to early 1990s, and typically a dose of
4 g fosfomycin was given before surgery co-administered with metronidazole and
often repeated postoperatively. The risk of bias across studies was moderate to
high. The rates of infectious complications were low after fosfomycin; the
surgical site infection rate was 0–1% in emergency surgery and
0–10% in elective surgery. If reported, harms were few and mild
and typically related to the gastrointestinal system.
Conclusion There were few postoperative infectious complications after
perioperative parenteral administration of one or more doses of 4 g fosfomycin
supplemented with metronidazole in various gastrointestinal procedures.
Fosfomycin was associated with few and mild harms.
Prevention of peri-interventional hypothermia during endoscopic retrograde cholangiopancreatography using a forced-air heating system
Authors: Stahl Klaus , Schuette Eloise , Schirmer Paul , Fuge Jan , Weber Anna-Lena , Heidrich Benjamin , Schneider Andrea , Pape Thorben , Krauss Terence , Wedemeyer Heiner , Lenzen Henrike 
Published: November 2023

Abstract
Background and study aims Perioperative hypothermia is associated
with significant complications and can be prevented with forced-air heating systems (FAHS).
Whether hypothermia occurs during prolonged endoscopic sedation is unclear and prevention
measures are not addressed in endoscopic sedation guidelines. We hypothesized that hypothermia
also occurs in a significant proportion of patients undergoing endoscopic interventions
associated with longer sedation times such as endoscopic retrograde cholangiopancreaticography
(ERCP), and that FAHS may prevent it.
Patients and methods In this observational study, each patient
received two consecutive ERCPs, the first ERCP following current standard of care without FAHS
(SOC group) and a consecutive ERCP with FAHS (FAHS group). The primary endpoint was maximum
body temperature difference during sedation.
Results Twenty-four patients were included. Median (interquartile
range) maximum body temperature difference was −0.9°C (−1.2; −0.4) in the SOC and −0.1°C
(−0.2; 0) in the FAHS group (P < 0.001). Median body temperature
was lower in the SOC compared with the FAHS group after 20, 30, 40, and 50 minutes of
sedation. A reduction in body temperature of > 1°C (P <
0.001) and a reduction below 36°C (P = 0.01) occurred more often in
the SOC than in the FAHS group. FAHS was independently associated with reduced risk of
hypothermia (P = 0.006). More patients experienced freezing in the
SOC group (P = 0.004). Hemodynmaic and respiratory stability were
comparable in both groups.
Conclusions Hypothermia occurred in the majority of patients
undergoing prolonged endoscopic sedation without active temperature control. FAHS was
associated with higher temperature stability during sedation and better patient
comfort.
Urgent ERCP performed with single-use duodenoscope (SUD) in patients with moderate-to-severe cholangitis: Single-center prospective study
Authors: Masciangelo Graziella , Cecinato Paolo , Bacchilega Igor , Masetti Michele , Ferrari Rodolfo , Zagari Rocco Maurizio , Napoleon Bertrand , Sassatelli Romano , Fusaroli Pietro , Lisotti Andrea 
Published: November 2023

Abstract
Background and study aims To assess the outcomes of urgent endoscopic retrograde cholangiopancreatography (ERCP) performed with a single-use duodenoscope (SUD) in patients with moderate-to-severe cholangitis.
Patients and methods Between 2021 and 2022 consecutive patients with moderate-to-severe cholangitis were prospectively enrolled to undergo urgent ERCP with SUD. Technical success was defined as the completion of the planned procedure with SUD. Multivariate analysis was used to identify factors related to incidence of adverse events (AEs) and mortality.
Results Thirty-five consecutive patients (15 female, age 81.4±6.7 years) were enrolled. Twelve (34.3%) had severe cholangitis; 26 (74.3%) had an American Society of Anesthesiologists (ASA) score ≥3. Twenty-eight patients (80.0%) had a naïve papilla. Biliary sphincterotomy and complete stone clearance were performed in 29 (82.9%) and 30 patients (85.7%), respectively; in three cases (8.6%), concomitant endoscopic ultrasound-gallbladder drainage was performed. Technical and clinical success rates were 100%. Thirty-day and 3-month mortality were 2.9% and 14.3%, respectively. One patient had mild post-ERCP pancreatitis and two had delayed bleeding. No patient or procedural variables were related to AEs. ASA score 4 and leucopenia were related to 3-month mortality; on multivariate analysis, leukopenia was the only variable independently related to 3-month mortality (odds ratio 12.8; 95% confidence interval 1.03–157.2; P=0.03).
Conclusions The results of this “proof of concept” study suggest that SUD use could be considered safe and effective for urgent ERCP for acute cholangitis. This approach abolishes duodenoscope contamination from infected patients without impairing clinical outcomes.
Patient Selection for Follicular Unit Extraction versus Linear Strip Donor Harvesting
Authors: Konior Raymond J. 
Published: November 2023

AbstractFollicular unit grafts can be harvested using two methods: strip follicular unit transplantation and follicular unit excision. Each method can generate outstanding results, but both are uniquely different with respect to the advantages and disadvantages they offer. Devising a sound surgical plan is instrumental to assure that a patient's short-term and long-term goals can be met, but creating the best plan possible for the graft harvest process is not straightforward. This paper will review the various advantages and disadvantages of each graft harvest method, along with their short-term and long-term ramifications, so as to provide insight into the process by which a sound surgical plan can be developed for any patient seeking surgical hair restoration.
Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases
Authors: Péč Martin Jozef , Jurica Jakub , Péčová Monika , Benko Jakub , Sokol Juraj , Bolek Tomáš , Samec Marek , Hurtová Tatiana , Galajda Peter , Samoš Matej , Mokáň Marián 
Published: November 2023

AbstractPlatelets are essential in maintaining blood homeostasis and regulating several inflammatory processes. They constantly interact with immune cells, have immunoregulatory functions, and can affect, through immunologically active substances, endothelium, leukocytes, and other immune response components. In reverse, inflammatory and immune processes can activate platelets, which might be significant in autoimmune disease progression and arising complications. Thus, considering this interplay, targeting platelet activity may represent a new approach to treatment of autoimmune diseases. This review aims to highlight the role of platelets in the pathogenic mechanisms of the most frequent chronic autoimmune inflammatory diseases to identify gaps in current knowledge and to provide potential new targets for medical interventions.
A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
Authors: Berger Dana Senderoff , Galyean Anna , Nguyen Kelvin , Alshak Najeeb , Blumenthal Elizabeth 
Published: November 2023

AbstractCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy.We present a morbidly obese 30-year-old woman with COVID-19 at 28 weeks' gestation complicated by significant transaminitis with peak liver enzymes levels of 501/1,313 (aspartate aminotransferase/alanine aminotransferase). Liver biopsy showed reactive changes consistent with medication effect and mild steatosis.Significant transaminitis has been found in both pregnant and nonpregnant patients with COVID-19. Our case demonstrates the multifactorial nature of liver injury in COVID-19 patients including mild underlying liver steatosis combined with possible viral potentiation of medication effect.
Evaluations of training programs to improve capacity in K*: a systematic scoping review of methods applied and outcomes assessed
Authors: Shewchuk Samantha , Wallace James , Seibold Mia 
Published: November 2023

AbstractThis paper examines how frequently K* training programs have been evaluated, synthesizes information on the methods and outcome indicators used, and identifies potential future approaches for evaluation. We conducted a systematic scoping review of publications evaluating K* training programs, including formal and informal training programs targeted toward knowledge brokers, researchers, policymakers, practitioners, and community members. Using broad inclusion criteria, eight electronic databases and Google Scholar were systematically searched using Boolean queries. After independent screening, scientometric and content analysis was conducted to map the literature and provide in-depth insights related to the methodological characteristics, outcomes assessed, and future evaluation approaches proposed by the authors of the included studies. The Kirkpatrick four-level training evaluation model was used to categorize training outcomes. Of the 824 unique resources identified, 47 were eligible for inclusion in the analysis. The number of published articles increased after 2014, with most conducted in the United States and Canada. Many training evaluations were designed to capture process and outcome variables. We found that surveys and interviews of trainees were the most used data collection techniques. Downstream organizational impacts that occurred because of the training were evaluated less frequently. Authors of the included studies cited limitations such as the use of simple evaluative designs, small cohorts/sample sizes, lack of long-term follow-up, and an absence of curriculum evaluation activities. This study found that many evaluations of K* training programs were weak, even though the number of training programs (and the evaluations thereof) have increased steadily since 2014. We found a limited number of studies on K* training outside of the field of health and few studies that assessed the long-term impacts of training. More evidence from well-designed K* training evaluations are needed and we encourage future evaluators and program staff to carefully consider their evaluation design and outcomes to pursue.
Heavy quark energy loss through polarization and radiation in the hot QCD medium
Authors: Prakash Jai , Yousuf Jamal Mohammad 
Published: November 2023

Abstract
We present a comparative study on the heavy quarks energy loss through medium polarization and gluon radiation in the quark-gluon plasma. To do so, we investigated the energy loss per unit length and drag coefficient for both cases. To have better contrast, we also obtained the nuclear modification factor employing Langevin dynamics. The comparison shows that the polarization effect dominates at lower momentum. The medium temperature also plays an important role in the comparison.
Self-matching extraction fractional wavelet transform for mechanical equipment fault diagnosis
Authors: Liu Yang , Dan Binbin , Yi Cancan , Huang Tao , Zhang Fuqi 
Published: November 2023

Abstract
Time-frequency analysis (TFA) of vibration signals is an important way for fault diagnosis and predictive maintenance of mechanical equipment. However, the existing TFA methods, such as wavelet transform (WT) and synchrosqueezing transform, are incapable to describe local details of strongly time-varying signals, bringing such problems as time-frequency energy dispersion. Theoretically, it is more beneficial for time-varying band-limited signals to make multi-resolution analysis in the time-fraction frequency domain because such action can increase the selection chances of mother wavelets in any direction on the time-frequency plane by changing the angle

α

. In order to improve the ability of analyzing strongly time-varying signals and the readability of the time-frequency plane, this paper has proposed a novel TFA method called self-matching extraction fractional WT (SMEFRWT). Firstly, within the theoretical framework of fractional WT (FRWT), a minimum entropy-based method is proposed to choose an optimal angle in the fractional domain. Such action can obtain the best aggregation angle of time-frequency energy and facilitate the separation of multi-component signals. Then, self-matching extraction operator, one instantaneous-frequency estimated operator that match the time-frequency structure of amplitude modulation signals, is constructed. The operator allows for the distribution of time-frequency energy of fast-changing signals in both frequency and time directions, making it possible to match the time-varying vibration signals from mechanical equipment more accurately. Finally, SMEFRWT is adopted to make TFA and extract fault features of the faulty experiment benches on gear and bearings, with its feasibility validated by experimental results.