bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory Measurements of Permeability and Porosity of the Matrix and Created Fractures: Application to the Pressure Falloff Analysis Following Well Stimulation to Determine Effective Fracture Spacing in Field
Authors: Mindygaliyeva B. , Uzun O. , Amini K. , Kazemi H. 
Published: October 2023

Abstract
We present an analysis of several multi-rate pressure falloff data following well stimulation in the Utah FORGE enhanced geothermal system (EGS) injection well. The purpose of the analysis was to determine the effective stimulated permeability and representative fracture spacing in the stimulated formation volume. The Utah FORGE geothermal system is a very low-permeability, dry granitoid; therefore, it is necessary to create permeable flow channels in the formation for the injection water to penetrate and extract heat for power generation. We have previously used the same pressure falloff analysis procedure in numerous unconventional reservoirs. We measured the permeability of the matrix rock and the permeability of an embedded fracture, as well as the porosity for several 1-1/2-inch by 2-inch cores. Then, we used the measured permeabilities and porosities in the analysis of multi-rate pressure falloff field data to determine the effective macro-fracture spacings adjacent to the hydraulic fractures. The cores used for the experimental study were outcrop granite, geothermal granitoid, and several unconventional (Niobrara, Codell, Wolfcamp) reservoirs. To determine a representative macro-fracture spacing associated with the hydraulic fractures, the pressure falloff field data analyses were fine-tuned via numerical modeling iteratively. Finally, the experimentally measured core porosities and permeabilities were used as input data for the interpretation of the analytical model used in the pressure falloff test analyses. Such analysis indicates that fracturing fluid entering the rock surrounding the hydraulic fracture is dominated by the micro-fractures. Nonetheless, it is important to note that FORGE rock is highly water wet; thus, water imbibition plays a significant role in water entering the rock pores despite their low permeabilities. Finally, one can appreciate the importance of the stimulated fractured zone both in providing surface area for heat extraction in geothermal wells and for mass transport in improving primary production and EOR in unconventional shale reservoirs.
Real-Time Lithology Prediction While Drilling Using Machine Learning Algorithms: A Web Application Based Solution
Authors: Mensah A. O. 
Published: October 2023

Abstract
Formation lithology is a vital information source for initial well economic assessment, reservoir lithology description, geological correlation, formation identification, verification of wireline log response, and identification of hydrocarbon deposits. Real-time lithology determination while drilling can greatly optimise the drilling process and enhance geosteering. Using linear, non-linear, and ensemble machine learning algorithms, this study sought to automate the process of lithology classification while drilling. Also, the project sought to create a web application with a graphical user interface to enable the users easily train and save models which can be applied on different lithology classification projects without the need to code. A public dataset containing mudlog and lithology data from ten wells in the Volve oil field, Norway, was used in this study. The graphical user interface was then created using Streamlit and Python programming language to allow for easier application of the machine learning algorithms without a prior programming knowledge. The results showed that the ensemble methods (Random Forest classifier and Gradient Boosting classifier) outperformed the other linear (logistic regression) and non-linear (Support Vector) machine learning algorithms. Random Forest classifier achieved an overall accuracy of 99% and a precision of 98% while the Gradient Boosting classifier had an accuracy score of about 97% and a precision of 92% in classifying the six lithology types from ten wells. The results obtained showed that implementing ensemble machine learning algorithms with a graphical user interface can assist Engineers to classify lithology efficiently, easily, and timely while drilling. This web application can also be used by geologists and geophysicists to classify lithology using machine learning without the need to write codes.
Synergistic Influence Between Surfactants and Nanoparticles in Foam Flooding as an Optimization Method for Gas EOR
Authors: Bello Ayomikun 
Published: October 2023

Abstract
Foam flooding is positioned to be one of the promising oil recovery techniques to keep up with the continuously increasing global energy demand. Due to their low sensitivity to gravity and permeability heterogeneities that boost sweep efficiency, foams are preferred injection fluids over water or gas. However, this method is not frequently used because of the thermodynamic instability of foams. Therefore, a stable additive that maintains the foam properties in reservoir conditions is needed. Due to its promising properties, such as interfacial tension reduction, increased viscosity and density, wettability modification, and others, nanoparticles have gained attention for their various applications in oil recovery. Even though a number of factors have been studied in the past in relation to increasing foam stability with nanoparticles, the ideal conditions for achieving effective foamability and stability are still unknown. The majority of the experiments were conducted under ambient conditions. However, screening should be carried out under reservoir condition because it is important influence on foam enhanced oil recovery (EOR). As a result, in this work, foam qualities were examined at high temperatures and pressures as well as, in the presence of a synthetic formation brine. Firstly, preliminary experiments, which included surfactants and nanoparticles screening, were conducted. Three different ionic surfactant types were examined for this purpose at various temperatures, concentrations of monovalent and divalent salts, and a synthetic formation brine. Then, bulk foam stability investigations were carried out under ambient and thermobaric conditions. The morphology and texture of the foam were assessed using microscopic examinations. The ideal nano-augmented surfactant solution was then foamed with CO2 and used in core flooding studies.
Application of Bio and Biobased Surfactants as Demulsifiers for Destabilization of Water in Crude Oil Emulsions
Authors: Drochomirecki Jakub Mateusz 
Published: October 2023

Abstract
A process of breaking ‘water in oil’ type of emulsions by using demulsifiers based on bio and biobased surfactants and comparison of their effectiveness with commercial demulsifier presented by creation of: five bio demulsifiers, ‘water in oil’ type emulsion and conduction of the analyze of: the impact of those agents on process of emulsion breaking by using the thermochemical method and comparison it with effectiveness of commercial one and an optimal doze of active compound in demulsifier which allows to effectively break emulsion. Testing set consists of: Oil samples from ‘Jaszczew’ field with different dozes of demulsifiers, source of biosurfactants, commercial demulsifiers in order to compare effectiveness between them, stirrer to mix brine with oil and water bath with thermostat. Research part consists of creating w/o emulsion which is stabile in time and does not break under influence of gravity in short time, creation of bio demulsifiers based on chosen sources of bio surfactants like for example soapwort, coconut betaine and lauryl glucoside, and mixed with brine (around 30 % of NaCl), choosing optimal concentration of source of surfactant which would allow to break emulsion instead of stabilizing it, and too chose optimal temperature of process, in range between 20-60 C, which enhance decrease of viscosity of emulsion. The performance of biodemulsifier Is compared with performance of commercial demulsifier. Comparisons are also provided for optimal ranges in which demulsifiers act like emulsion breakers and outside of which start acting like emulsifier.
Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in patients with schizophrenia
Authors: Becker Maxi , Fischer Djo , Gallinat Jürgen , Kühn Simone 
Published: October 2023

Abstract

Recent research shows that videogame training enhances neuronal plasticity and cognitive improvements in healthy individuals. As patients with schizophrenia exhibit reduced neuronal plasticity linked to cognitive deficits and symptoms, we investigated whether videogame-related cognitive improvements and plasticity changes extend to this population. In a training study, patients with schizophrenia and healthy controls were randomly assigned to 3D or 2D platformer videogame training or E-book reading (active control) for 8 weeks, 30 minutes daily. After training, both videogame groups showed significant increases in sustained attention compared to the control group, correlated with increased functional connectivity in a hippocampal-prefrontal network. Notably, patients trained with videogames mostly improved in negative symptoms, general psychopathology, and perceived mental health recovery. Videogames, incorporating initiative, goal setting and gratification, offer a training approach closer to real life than current psychiatric treatments. Our results provide initial evidence that they may represent a possible adjunct therapeutic intervention for complex mental disorders.
Ovarian metastatic lung adenocarcinoma： a retrospective clinicopathological analysis of a consecutive 10-year case series
Authors: Liu Wei , Cui Yan-mei , Wang Xiao-jiang , Lin Xian-dong , Zhang Li-bin , Liu Jing-cheng , Lyu Qing-hu , Chen Wei , Hu Dan 
Published: October 2023

Abstract
Background
Ovarian metastatic lung adenocarcinoma is rarely detected in clinical practice, and only a few cases have been reported. Its clinicopathological features, molecular genetics, and prognosis have not been well characterized.
Results
Seventeen patients diagnosed with ovarian metastatic lung adenocarcinoma between 2013 and 2022 were analyzed retrospectively. All patients were non-smokers, with a median age of 46 years (range, 30 to 71y). Unilateral ovarian involvement was more frequent than bilateral involvement (58.8% vs 41.2%). Lesions presented as solid ovarian or mixed cystic and solid masses, and nearly two-thirds of the tumors (64.7%) had a diameter greater than 10 cm. More than one-third of the patients (41.2%) initially presented with pelvic masses with abdominal distension and/or lower abdominal pain, 100% of patients had elevated CA125 levels, and 76.5% had ascites. Most patients (76.5%) harbored driver gene alterations, including eight cases with EML4-ALK gene fusion and five cases with EGFR mutation. ALK rearrangement tumors showed solid adenocarcinomas (6/8,75.0%) and mucinous adenocarcinomas (2/8, 25.0%); however, acinar adenocarcinoma (6/9, 66.7%) was the most common type in non-ALK rearrangement cases. The 3-year overall survival (OS) of patients with ALK rearrangement and non-ALK rearrangement was 80.0% and 30.0%, respectively (p < 0.05).
Conclusion
Ovarian metastatic lung adenocarcinoma exhibits distinctive clinicopathological features and can mimic primary ovarian carcinoma. ALK rearrangement is the most common molecular alteration, and these patients have a better prognosis than those with non-ALK rearrangement. Genetic testing is recommended in all patients with ovarian metastatic lung adenocarcinoma to provide them with an opportunity to undergo targeted therapy.
Relationship between dietary carotenoid intake and sleep duration in American adults: A population-based study
Authors: Deng Ming-Gang , Liu Fang , Wang Kai , Liang Yuehui , Nie Jia-Qi , Liu Jiewei 
Published: October 2023

Abstract
Objective
To investigate the relationship between dietary carotenoid intake and sleep duration.
Methods
Adults enrolled in the National Health and Nutrition Examination Survey (NHANES) 2007–2018 without missing information on dietary carotenoid intake (α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein + zeaxanthin), sleep duration, and covariates were included. Participants’ carotenoid consumption was divided into three groups by quartiles and sleep duration was grouped as short (< 7 h/night), optimal (7–8 h/night), and long (> 8 h/night). Multinominal logistic regression was constructed to examine the association between dietary carotenoid intake and sleep duration. Restricted cubic spline (RCS) regression was further utilized to explore their dose-response relationship. The weighted quantile sum (WQS) model was adopted to calculate the mixed and individual effect of 5 carotenoid sub-types on sleep duration.
Results
Multinominal logistic regression presented that people with higher intakes of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein + zeaxanthin were less likely to sleep too short or too long. Consistent with the findings from multinominal logistic regression, the RCS models suggested a reverse U-shaped relationship between sleep duration and carotenoid intakes. The mixed effects were also significant, where lutein + zeaxanthin and β-cryptoxanthin, α-carotene and β-cryptoxanthin were the top 2 contributors associated with the decreased risks of short and long sleep duration, respectively.
Conclusion
People with higher carotenoid intakes were more likely to keep an optimal sleep duration, and targeted supplements may be helpful for short and long-sleepers.
Evaluation of organochlorine pesticides in samples of Astyanax Altiparanae Fish from an important reservoir in Brazil and Risk assessment
Authors: Stremel Tatiana R. de O. , Silva Cleber Pinto da , Domingues Cinthia E. , Voigt Carmem Lucia , Pedroso Carlos Raphael , Vidal Carlos Magno de Sousa , Campos Sandro X. 
Published: October 2023

Abstract
The Alagados reservoir is located in one of the main grain-producing and exporting areas in Brazil. Additionally, it is situated beneath the Guarani Aquifer, one of the largest aquifers in the world, which is an important source of groundwater for several countries in South America. Residues of organochlorine pesticides (OCPs) were detected in roe, viscera, and muscle of Astyanax altiparanae from the Alagados reservoir (Paraná State, Brazil) by GC/ECD. The detected OCPs include Aldrin (17.1 to 50.6 µg/Kg), α-endosulfan (3.4 to 23.5 µg/Kg), p,p’-DDE (4.2 to 134.7 µg/Kg), Dieldrin (84.7 to 183.1 µg/Kg), β-endosulfan (6.0 to 51.6 µg/Kg), and p,p’-DDT (56.6 to 286.8 µg/Kg) in roe; Aldrin (19.8 to 93.3 µg/Kg), α-endosulfan (8.3 to 37 µg/Kg), p,p’-DDE (83.5 to 209.2 µg/Kg), Dieldrin (18.0 to 193.5 µg/Kg), β-endosulfan (21.0 to 95.4 µg/Kg), and p,p’-DDT (52.3 to 89.2 µg/Kg) in viscera; and Aldrin (8.28 to 26.16 µg/Kg), α-endosulfan (4.16 to 12.3 µg/Kg), p,p’-DDE (12.7 to 40.17 µg/Kg), Dieldrin (45.6 µg/Kg), β-endosulfan (8.58 to 58.54 µg/Kg), and p,p’-DDT (12.0 to 23.1 µg/Kg) in muscle. Principal component analysis showed a proportional relationship between the highest concentrations of OCPs and the width of the fish abdomen. The levels of OCPs detected in Astyanax altiparanae samples did not exceed the maximum residue limits imposed by the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO). However, risk quotient calculations indicated possible health risks associated with the consumption of these fish.
Acaricidal efficacy of aqueous extracts from different plants on Tetranychus urticae Koch, 1836 (Acari: Tetranychidae)
Authors: Alpkent Yasin Nazım , Ulusoy Selçuk , ERTÜRK Sait 
Published: October 2023

Abstract

The two-spotted spider mite (Tetranychus urticae Koch,1836, Acari: Tetranychidae) causes significant yield losses in cultivated plants, especially depending on the season. Chemical methods are the main methods of controlling this pest. However, besides the environmental, human, and animal health problems arising from chemical control, adverse effects such as resistance and residues limit the success and sustainability of chemical control. In this study, the potential acaricidal effect of aqueous extracts of Morus rubra, Daphne odora, Ficus carica, Matricaria chamomilla, and Mentha pulegium collected from Ankara and Adana provinces on T. urticae was investigated. For this purpose, the leaves of the plants were dried and ground and 1%, 3%, 6%, and 12% concentrations (v/v) of the extracts obtained were tested in three different application periods (1-6-day). Dipping and spraying methods were used to determine mortality and toxicity. The highest effect was 94.4% at the end of the 6th day at a 12% concentration of M. pulegium in the dipping method. On the other hand, the lowest mortality effect was 18.2% at the same time and concentration of M. chamomilla. In lethal toxicity studies, the highest toxicity was obtained from F. carica with an LC50 value of 4756 mg L− 1, and the lowest toxicity was obtained from D. odora with an LC50 value of 12417 mg L− 1. We believe that plant extracts provide a valid alternative in effectively controlling two-spotted spider mites, reducing the need for pesticide use and minimizing residues.
Hearing Rehabilitation in Patients with SERAC1 Related MEGD(H)EL Syndrome
Authors: Roesch Sebastian , O´Sullivan Anna , Tschani Stefan , Mayr Johannes A. , Baghdasaryan Anna , Balasubramaniam Shanti , Barić Ivo , de Boer Lonneke , Grünert Sarah C. , Guzek Anna , Janssen Mirian , Krumina Zita , Koenig Mary Kay , Mochel Fanny , Naldi Arianne Monge , Plecko Barbara , Öztürk Kerem , Riordan Gillian , Rymen Daisy , Santer René , Schiff Manuel , Stettner Georg M. , Tsiakas Konstantinos , Uçar Sema Kalkan , Uzun Özlem Ünal , Weigel Corina , Witters Peter , Iwanicka-Pronicka Katarzyna , Wortmann Saskia B. 
Published: October 2023

Abstract
Background

SERAC1 related MEGD(H)EL syndrome is a rare but regularly severely disabling and progressive inborn metabolic disease characterized by 3-methylglutaconic aciduria, dystonia and deafness, encephalopathy, (hepatopathy) and a Leigh syndrome-like presentation. Knowledge on hearing rehabilitation in affected individuals is scarce but important for being a possible therapeutic intervention in many cases. We investigated the details of hearing impairment and response to hearing rehabilitations in 35 MEGD(H)EL patients.

Methods

Retrospective, cross-sectional study.

Results

A total of 35 patients from sixteen international centres were included for analysis. Bilateral hearing loss was reported in 30 patients (30/35, 85%). In patients, representing the mild end of the spectrum of MEGD(H)EL syndrome with juvenile onset of symptoms, hearing impairment appeared not to be a compellent symptom.
Both cochlear and retro-cochlear hearing loss was diagnosed. Fifteen patients, all with pre-lingual hearing loss, were treated with conventional hearing aids, five patients with cochlear implants. None of the patients with hearing rehabilitation, neither hearing aids, nor cochlear implant, developed spoken language. The only benefit reported, independent from type of rehabilitation, was an improved awareness to environmental sounds.

Conclusion

Valid audiometric data in patients with MEGD(H)EL syndrome was limited, therefore, definite characterization of type of hearing loss in the whole group was not possible. However, hearing rehabilitation with conventional hearing aids was possible and should be offered to all patients, knowing that spoken language seems not to be achievable. Likewise, cochlear implants seem to offer limited additional benefit.
Oncofetal SNRPE promotes HCC tumorigenesis by regulating FGFR4 expression through alternative splicing
Authors: Jiang Zhenzhou , Wu Qipeng , Liao Ruyan , Miao Chunmeng , Hasnat Muhammad , Li Le , Sun Lixin , Wang Xinru , Yuan Ziqiao , zhang luyong , Yu Qinwei 
Published: October 2023

Abstract
Understanding the roles of spliceosome and splicing events during tumorigenesis opens new avenues for targeted therapies. Here, we identified that small nuclear ribonucleoprotein polypeptide E (SNPRE) is an oncofetal splicing factor, which had a link in the poor prognosis of hepatocellular carcinoma (HCC), and was reactivated by SOX2. SNRPE knockdown effectively abolished HCC tumorigenesis and progression. Transcriptome analysis and RT-PCR results revealed that SNRPE knockdown induced intron retention (intron 4) in the fibroblast growth factor receptor 4 (FGFR4) transcript. Mechanistically, SNRPE knockdown reduced FGFR4 mRNA expression by activating nonsense-mediated RNA decay. FGFR4 knockdown partially blocked the SNRPE-induced malignant progression of HCC cells. Our findings discovered SNRPE as a novel oncofetal splicing factor and elucidated the relationship between oncofetal splicing factors, splicing events and carcinogenesis. Therefore, SNRPE is a potential target for HCC treatment.
Crossing host boundaries: the evolutionary drivers and correlates of viral host jumps
Authors: Tan Cedric , Dorp Lucy van , Balloux Francois 
Published: October 2023

Abstract
Most emerging and re-emerging infectious diseases stem from viruses that naturally circulate in non-human vertebrates. When these viruses cross over into humans, they can cause disease outbreaks and epidemics. While zoonotic host jumps have been extensively studied from an ecological perspective, little attention has gone into characterising the evolutionary drivers and correlates underlying these events. To address this gap, we harnessed the entirety of publicly available viral genomic data, employing a comprehensive suite of network and phylogenetic analyses. We address a series of questions concerning the evolutionary mechanisms underpinning viral host jumps. Notably, we challenge conventional assumptions about the directionality of host jumps, demonstrating that humans are as much a source as a sink for viral spillover events, insofar we infer more viruses to have jumped from humans to other animals, than from animals to humans. Moreover, we demonstrate heightened evolution in viral lineages that involve putative host jumps. We further observe that the mutational threshold associated with a host jump is lower for viruses with broad host ranges. Finally, we show that the genomic targets of natural selection upon a successful host jump vary across different viral families with either structural or auxiliary genes being the prime targets of selection. Collectively, our results illuminate some of the evolutionary drivers underlying viral host jumps that may contribute to mitigating viral threats across species boundaries.