bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broadband target strength of arabesque greenling, Pacific sand lance, and pointhead flounder
Authors: Yan Naizheng , Mukai Tohru , Hasegawa Kohei , Yamamoto Jun , Fukuda Yoshiaki 
Published: December 2023

Abstract
Measurement of target strength (TS) is important for estimating the abundance of species using fisheries acoustics. However, most researchers have only used a limited number of representative frequencies for acoustic measurements of fish without a swim bladder (bladderless fish). Here, we measured the broadband TS of three bladderless fish species, arabesque greenling (Pleurogrammus azonus), Pacific sand lance (Ammodytes personatus), and pointhead flounder (Cleisthenes pinetorum), using two broadband echosounders. TS measurements were conducted in a seawater tank over frequency ranges of 45–90 and 80–120 kHz using a tether method. Higher TS and directivity were observed at higher frequencies than at lower frequencies for pointhead flounder and arabesque greenling. However, the TS for Pacific sand lance was relatively flat over the measured frequency spectra. Additionally, the TS of pointhead flounder and Pacific sand lance could be expressed as a function of body length and the TS of arabesque greenling could be expressed as a function of body length and frequency, which could be used in fish species discriminations and size estimations.
Exact Mobility Edges for Almost-Periodic CMV Matrices via Gauge Symmetries
Authors: Cedzich Christopher , Fillman Jake , Li Long , Ong Darren C , Zhou Qi 
Published: December 2023

Abstract
We investigate the symmetries of the so-called generalized extended Cantero–Moral–Velázquez (CMV) matrices. It is well-documented that problems involving reflection symmetries of standard extended CMV matrices can be subtle. We show how to deal with this in an elegant fashion by passing to the class of generalized extended CMV matrices via explicit diagonal unitaries in the spirit of Cantero–Grünbaum–Moral–Velázquez. As an application of these ideas, we construct an explicit family of almost-periodic CMV matrices, which we call the mosaic unitary almost-Mathieu operator, and prove the occurrence of exact mobility edges. That is, we show the existence of energies that separate spectral regions with absolutely continuous and pure point spectrum and exactly calculate them.
RNA Landscapes of Brain and Brain-Derived Extracellular Vesicles in Simian Immunodeficiency Virus Infection and Central Nervous System Pathology
Authors: Huang Yiyao , Abdelgawad Ahmed , Turchinovich Andrey , Queen Suzanne , Abreu Celina Monteiro , Zhu Xianming , Batish Mona , Zheng Lei , Witwer Kenneth W 
Published: December 2023

Abstract

Background
Brain tissue-derived extracellular vesicles (bdEVs) act locally in the central nervous system (CNS) and may indicate molecular mechanisms in human immunodeficiency virus (HIV) CNS pathology. Using brain homogenate (BH) and bdEVs from a simian immunodeficiency virus (SIV) model of HIV disease, we identified RNA networks in SIV infection and neuroinflammation.

Methods
Postmortem occipital cortex samples were obtained from uninfected controls and SIV-infected subjects (acute and chronic phases with or without CNS pathology [SIV encephalitis]). bdEVs were separated and characterized per international consensus guidelines. RNAs from bdEVs and BH were sequenced and quantitative polymerase chain reaction (qPCR)-amplified to detect levels of small RNAs (sRNAs, including microRNAs [miRNAs]) and longer RNAs including messenger RNAs (mRNAs) and circular RNAs (circRNAs).

Results
Dysregulated RNAs in BH and bdEVs were identified in acute and chronic infection with pathology groups, including mRNAs, miRNAs, and circRNAs. Most dysregulated mRNAs in bdEVs reflected dysregulation in source BH. These mRNAs are disproportionately involved in inflammation and immune responses. Based on target prediction, several circRNAs that were differentially abundant in source tissue might be responsible for specific differences in sRNA levels in bdEVs during SIV infection.

Conclusions
RNA profiling of bdEVs and source tissues reveals potential regulatory networks in SIV infection and SIV-related CNS pathology.
Developing quality measures for non-pharmacological prevention and rehabilitation in primary health care for chronic conditions: a consensus study
Authors: Svendsen Marie Louise , Andersen Tina Veje , Soendergaard Hanne 
Published: December 2023

Abstract
Poor health-related behaviours are root causes of a large number of chronic conditions; however, this study is the first to develop guideline-based quality measures targeting health-related behaviours through generic non-pharmacological secondary prevention and rehabilitation in municipal primary health care for persons with chronic conditions.
From January 2020 to September 2021, a consensus study was conducted in accordance with the current scientific recommendations for developing guideline-based quality measures. A clinical expert panel (n = 11) was established and included a patient representative, health care professionals, researchers, and key specialists. The process for developing quality measures was led by methodologists and encompassed a modified Research and Development/University of California at Los Angeles (RAND/UCLA) study to evaluate consensus in the expert panel. The consensus recommendations were directed to a steering group including the Danish Ministry of Health, the Danish Regions, and the Local Government Denmark.
The expert panel rated 102 clinical practice recommendations. Consensus was demonstrated on 13 quality measures assessing whether the patients are offered participation in and adhere to: self-management, smoking cessation, physical exercise training, nutritional efforts, and preventive consultation on excessive alcohol consumption; whether the patients participate in a closing meeting, whether they are offered follow-up, and whether reasons for dropout are documented.
The identified quality measures constitute a framework for assessing the quality of non-pharmacological prevention and rehabilitation in municipal primary health care for persons with chronic conditions. The next steps focus on field testing of the quality measures to refine measure criteria and assess implementation. A close link between clinical practice, the evidence and practice recommendations, the data infrastructure, economic considerations, and national priorities was a key to the consensus process.
Textiling World Politics: Towards an extended epistemology, methodology, and ontology
Authors: Andrä Christine , Bliesemann de Guevara Berit , Querejazu Amaya , Santos Victória M S 
Published: December 2023

AbstractThis article argues that textiling—a particular kind of making that simultaneously constitutes a concept, a metaphor, and a practice—can facilitate a radical rethinking and redoing of the study of world politics. Specifically, we suggest three ways in which textiling, and the relationality it enables, facilitates this innovation: as a different way of theorizing in the discipline of international relations (IR), as a creative method and methodology for the empirical study of world politics, and as ontological world-making through cosmopraxis. These three ways open up possibilities of engaging the world and its politics differently by enabling an extended epistemology that accounts not only for propositional (abstract and textual) knowledge, but also for experiential, presentational, and practical ways of knowing. Thereby, textiling is not only an innovative practical instrument by means of which different research traditions within IR can cultivate non-propositional ways of knowing; it can also entangle these new insights with the propositional knowledge traditionally privileged by IR and interweave theory and practice in IR scholarship.
The Empire Strikes Back: Comparing US and China’s Structural Power in Outer Space
Authors: Morin Jean-Frédéric , Tepper Eytan 
Published: December 2023

Abstract
This article assesses the structural power of the United States and China in the field of space governance. While much of the literature on space power focuses on their technologies and capabilities, we take a complementary approach and explore their capacity to shape the regulatory landscape. Possessing structural power has far-reaching implications for global power projection as well as for various industries, such as telecommunications, transportation, and remote sensing. To assess structural power, we gathered and analyzed three types of data: a dataset featuring 1,709 space organizations, a second dataset comprising 1,764 international space arrangements connecting them, and insights from fifty-two interviews with key space actors. Our findings indicate that the United States holds significant structural power thanks to its thriving commercial space sector and extensive international network. This has enabled the global diffusion of its preferred norms while simultaneously constraining China’s space cooperation network. Despite its remarkable technological capabilities, China has not been able to translate them into substantial global structural power. To encourage further exploration in this domain, we make available our original dataset of 1,764 space arrangements, including 970 in full-text format, inviting fellow researchers to investigate other facets of outer space governance.
Impact of antibiotic allergy labels on timely and appropriate antibiotics for sepsis in the emergency department
Authors: Rush Lily , Rashidzada Zohal , Cairns Kelly , Roman Cristina , Bourne Thomas , Orosz Judit , Poole Susan , Lee Sue J , Peel Trisha 
Published: December 2023

Abstract

Objectives
Time to initiation of effective antibiotic therapy is a strong predictor of survival for patients with sepsis presenting to the Emergency Department (ED). Antibiotic allergy labels (AALs) are a known barrier to timely sepsis management. The aim was to evaluate the influence of AALs on timely sepsis management for ED sepsis presentations in an Australian hospital.

Methods
A retrospective cohort study was conducted for ED presentations requiring direct ICU admission for suspected sepsis, comparing patients with and without an AAL using propensity scores.

Results
Between November 2018 and June 2021, 377 patients were included. The prevalence of an AAL was 29.6% (86/377). The median time to antibiotic administration was similar in the AAL versus non-AAL groups (51 versus 60 min, P = 0.11); there was no difference in mortality (14.1% versus 14.0%, P = 0.98) and length of stay (9.21 versus 10.10 days). The median time to antibiotic administration was shorter in those with Emergency Medicine (EM) pharmacist attendance versus those without (50 versus 92 min, P = 0.0001). Appropriateness of antibiotic prescription was 91.0% (343/377) for the overall cohort and was not associated with AALs, possibly due to our clear antimicrobial sepsis guidelines; however, EM pharmacist involvement was associated with increased antibiotic appropriateness (97.3% versus 88.4%, P = 0.00048).

Conclusions
In our Australian ED, AALs were not found to impact timeliness of antibiotic administration in patients with sepsis. EM pharmacist involvement was associated with improved timeliness and appropriateness of antibiotic selection in patients presenting with sepsis.
In vitro activity of tebipenem and comparator agents against bacterial pathogens isolated from patients with cancer
Authors: Gerges Bahgat , Rosenblatt Joel , Shellburne Samuel A , Chaftari Anne-Marie , Hachem Ray , Raad Issam 
Published: December 2023

Abstract

Background
Tebipenem is a broad-spectrum orally administered carbapenem antibiotic that could be an alternative to IV carbapenems. The current study evaluated in vitro activity of tebipenem against bacterial isolates recovered from patients with cancer.

Methods
A total of 611 bacterial pathogens recently isolated from patients with cancer were tested for susceptibility to tebipenem and comparators. CLSI-approved broth microdilution methods were used. MIC50, MIC90, MIC range and percentage susceptibility calculations were made using FDA breakpoints when available.

Results
Tebipenem had a low MIC90 for most Gram-positive and Enterobacterales isolates. Tebipenem MIC90 ranged from 0.06 to 0.25 mg/L for all tested Enterobacterales.

Conclusions
Oral tebipenem has promising activity against clinically significant bacterial pathogens isolated from patients with cancer. Further clinical evaluation of tebipenem for the treatment of bacterial infections in patients with cancer is warranted.
Effects of 12 Months’ Treatment with Testosterone Undecanoate on Markers for Erythropoietic Activity and Safety Aspects in Transgender and Cisgender Hypogonadal Men
Authors: Lethin Kajsa , Aardal Elisabeth , Lood Yvonne , Ekman Bertil , Wahlberg Jeanette 
Published: December 2023

Abstract

Background
To investigate the erythropoietic activity and safety aspects of testosterone undecanoate (TU) injections in transgender men, assigned female at birth.

Methods
Twenty-three men (13 hypogonadal cisgender men and 10 transgender men) who initiated TU at the study start (naïve) and 15 men (10 hypogonadal cisgender men and 5 transgender men) on steady-state treatment with TU (non-naïve) were included in this prospective 1-year observational study. A control group of 32 eugonadal cisgender men was investigated once at baseline. Complete blood count, testosterone in serum and saliva, and plasma lipids, and liver enzymes were assessed.

Results
For naïve transgender men, a significant increase in hemoglobin concentration was noted (mean (SD)), 141 (8) g/L to 151 (13) g/L, while no increase was seen in naïve hypogonadal cisgender men. At the end of the study, naïve transgender men exhibited comparable levels of hemoglobin, hematocrit, and testosterone levels in serum and saliva to hypogonadal cisgender men, as well as to the eugonadal cisgender men. During the study, HDL-cholesterol decreased significantly in naïve transgender men, 1.4 (0.4) mmol/L to 1.2 (0.4) mmol/L, P = 0.03, whereas no significant change was noted in naïve hypogonadal cisgender men. Liver enzymes remained unchanged in all groups.

Conclusions
After 12 months of treatment with TU in naïve transgender men, hemoglobin and hematocrit increased to levels within the cisgender male reference range. A slight decrease in HDL-cholesterol was seen in naïve transgender men but liver enzymes remained unchanged.
Strategy and Subterfuge: Billy Graham’s Political Machinations from Montreux to the Mayflower Hotel and Beyond
Authors: Balmer Randall 
Published: December 2023

Abstract
One of the turning points in the 1960 presidential campaign was a gathering of 150 Protestant ministers at the Mayflower Hotel in Washington on September 7, 1960, two days after Labor Day. During the closed-door gathering, Protestant leaders, including Norman Vincent Peale, unanimously adopted a statement warning about the dangers to the First Amendment and the separation of church and state should a Roman Catholic be elected president. Drawing on newly available archival sources, this article examines the role of religion in the 1960 campaign, including John F. Kennedy’s long struggle to neutralize the issue and the significance of Paul Blanshard’s 1949 best-seller, American Freedom and Catholic Power. Although Peale was roundly criticized for his role in the Mayflower gathering, the real force behind the meeting was Billy Graham, who did not attend. After assuring Kennedy in a letter dated August 10, 1960, that he, Graham, would not raise the religious issue in the campaign, Graham, at Peale’s behest, convened a group of Protestant ministers at the Montreux Palace Hotel in Switzerland eight days later to discuss how they could deny Kennedy’s election in November. The direct consequence of the Montreux meeting was the Mayflower Hotel gathering. While Peale took the heat for the meeting, Graham continued to play both sides, insisting publicly that he was neutral in the presidential race while working behind the scenes to advance Nixon’s candidacy, a strategy he employed again twenty years later in an attempt to jettison the reelection of a fellow evangelical, Jimmy Carter.
Prostate cancer risk stratification using magnetic resonance imaging–ultrasound fusion vs systematic prostate biopsy
Authors: Khajir Ghazal , Press Benjamin , Lokeshwar Soum , Ghabili Kamyar , Rahman Syed , Gardezi Mursal , Washington Samuel , Cooperberg Matthew R , Sprenkle Preston , Leapman Michael S 
Published: December 2023

Abstract

Background
Image-guided approaches improve the diagnostic yield of prostate biopsy and frequently modify estimates of clinical risk. To better understand the impact of magnetic resonance imaging–ultrasound fusion targeted biopsy (MRF-TB) on risk assessment, we compared the distribution of National Comprehensive Cancer Network (NCCN) risk groupings, as calculated from MRF-TB vs systematic biopsy alone.

Methods
We performed a retrospective analysis of 713 patients who underwent MRF-TB from January 2017 to July 2021. The primary study objective was to compare the distribution of National Comprehensive Cancer Network risk groupings obtained using MRF-TB (systematic + targeted) vs systematic biopsy.

Results
Systematic biopsy alone classified 10% of samples as very low risk and 18.7% of samples as low risk, while MRF-TB classified 10.5% of samples as very low risk and 16.1% of samples as low risk. Among patients with benign findings, low-risk disease, and favorable/intermediate-risk disease on systematic biopsy alone, 4.6% of biopsies were reclassified as high risk or very high risk on MRF-TB. Of 207 patients choosing active surveillance, 64 (31%), 91 (44%), 42 (20.2%), and 10 (4.8%) patients were classified as having very low-risk, low-risk, and favorable/intermediate-risk and unfavorable/intermediate-risk criteria, respectively. When using systematic biopsy alone, 204 patients (28.7%) were classified as having either very low-risk and low-risk disease per NCCN guidelines, while 190 men (26.6%) received this classification when using MRF-TB.

Conclusion
The addition of MRF-TB to systematic biopsy may change eligibility for active surveillance in only a small proportion of patients with prostate cancer. Our findings support the need for routine use of quantitative risk assessment over risk groupings to promote more nuanced decision making for localized cancer.
Variable selection in latent variable models via knockoffs: an application to international large-scale assessment in education
Authors: Xie Zilong , Chen Yunxiao , von Davier Matthias , Weng Haolei 
Published: December 2023

Abstract
International large-scale assessments (ILSAs) play an important role in educational research and policy making. They collect valuable data on education quality and performance development across many education systems, giving countries the opportunity to share techniques, organisational structures, and policies that have proven efficient and successful. To gain insights from ILSA data, we identify non-cognitive variables associated with students’ academic performance. This problem has three analytical challenges: (a) academic performance is measured by cognitive items under a matrix sampling design; (b) there are many missing values in the non-cognitive variables; and (c) multiple comparisons due to a large number of non-cognitive variables. We consider an application to the Programme for International Student Assessment, aiming to identify non-cognitive variables associated with students’ performance in science. We formulate it as a variable selection problem under a general latent variable model framework and further propose a knockoff method that conducts variable selection with a controlled error rate for false selections.
Agency, Politics, and the “Impossible Domestic”: A Response to Walter Johnson’s “On Agency”
Authors: Zimmerman Angela Elisabeth 
Published: December 2023

Abstract
Walter Johnson’s point about “agency” can be extended to other central concepts of historical analysis: what might appear as a salutary extension of a foundational category of liberal democracy to the histories of enslaved people in fact forces those histories into frameworks that are, ultimately, those of enslavers. The interconnected insights of Black feminism and Queer theory—particularly about “domestic institutions”—suggest that politics is another of those categories that, like agency, risks forcing the histories of enslaved people into analytic categories of an ultimately white-supremacist liberalism.
Regulation of the trade-off between cold stress and growth by glutathione S-transferase phi class 10 (BcGSTF10) in non-heading Chinese cabbage
Authors: Shen Yunlou , Wang Guangpeng , Ran Jiajun , Li Yiran , Wang Huiyu , Ding Qiang , Li Ying , Hou Xilin 
Published: December 2023

Abstract
Cold stress is a serious threat to global crop production and food security, but plant cold resistance is accompanied by reductions in growth and yield. In this study, we determined that the novel gene BcGSTF10 in non-heading Chinese cabbage [NHCC; Brassica campestris (syn. Brassica rapa) ssp. chinensis] is implicated in resistance to cold stress. Biochemical and genetic analyses demonstrated that BcGSTF10 interacts with BcICE1 to induce C-REPEAT BINDING FACTOR (CBF) genes that enhance freezing tolerance in NHCC and in Arabidopsis. However, BcCBF2 represses BcGSTF10 and the latter promotes growth in NHCC and Arabidopsis. This dual function of BcGSTF10 indicates its pivotal role in balancing cold stress and growth, and this important understanding has the potential to inform the future development of strategies to breed crops that are both climate-resilient and high-yielding.
Genetic engineering low-arsenic and low-cadmium rice grain
Authors: Gui Yuejing , Teo Joanne , Tian Dongsheng , Yin Zhongchao 
Published: December 2023

Abstract
Rice is prone to take up the toxic elements arsenic (As) and cadmium (Cd) from paddy soil through the transporters for other essential elements. Disruption of these essential transporters usually adversely affects the normal growth of rice and the homeostasis of essential elements. Here we report on developing low-As and low-Cd rice grain through the co-overexpression of OsPCS1, OsABCC1, and OsHMA3 genes under the control of the rice OsActin1 promoter. Co-overexpression of OsPCS1 and OsABCC1 synergistically decreased As concentration in the grain. Overexpression of OsPCS1 also decreased Cd concentration in the grain by restricting the xylem-to-phloem Cd transport in node I, but paradoxically caused Cd hypersensitivity as the overproduced phytochelatins in OsPCS1-overexpressing plants suppressed OsHMA3-dependent Cd sequestration in vacuoles and promoted Cd transport from root to shoot. Co-overexpression of OsHAM3 and OsPCS1 overcame this suppression and complemented the Cd hypersensitivity. Compared with non-transgenic rice control, co-overexpression of OsABCC1, OsPCS1, and OsHMA3 in rice decreased As and Cd concentrations in grain by 92.1% and 98%, respectively, without causing any defect in plant growth and reproduction or of mineral nutrients in grain. Our research provides an effective approach and useful genetic materials for developing low-As and low-Cd rice grain.