bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate finance at a crossroads: it is high time to use the global solution for global problems
Authors: Qi Ji , Qian Haoqi 
Published: November 2023

AbstractThe failure of the USD 100-billion climate finance pledge under the United Nations Framework Convention on Climate Change (UNFCCC) could be attributed to a series of reasons: the inconsistent rules, the ambiguity of accountability issues, the political and economic motivations of donor countries, the weak governance capability of developing countries, etc. In addition to the predicament of climate finance commitments made by industrialized nations, South-South cooperation is becoming an important supplemental approach and is acknowledged by the Paris Agreement as an essential means of support. Through studying a broad set of literature on climate finance governance, the study aims to provide a clear picture of the current muddle in climate finance and China’s new role in the architecture. We do this by first looking into the disjointed system of reporting and accounting standards for climate finance as well as what causes the international climate finance gap. On the one hand, the self-interests and geopolitical concerns of donor countries led to considerable challenges to distributive justice in climate finance allocation. On the other hand, climate finance from rich countries has yet to make a substantial dent in enhancing developing countries’ resilience to climate change. Finally, we argue that China-led climate-related development assistance and South-South cooperation on climate change has a tremendous potential for vulnerable countries to realize their climate action priorities and address the climate injustice.
Auditing of AI: Legal, Ethical and Technical Approaches
Authors: Mökander Jakob 
Published: November 2023

AbstractAI auditing is a rapidly growing field of research and practice. This review article, which doubles as an editorial to Digital Society’s topical collection on ‘Auditing of AI’, provides an overview of previous work in the field. Three key points emerge from the review. First, contemporary attempts to audit AI systems have much to learn from how audits have historically been structured and conducted in areas like financial accounting, safety engineering and the social sciences. Second, both policymakers and technology providers have an interest in promoting auditing as an AI governance mechanism. Academic researchers can thus fill an important role by studying the feasibility and effectiveness of different AI auditing procedures. Third, AI auditing is an inherently multidisciplinary undertaking, to which substantial contributions have been made by computer scientists and engineers as well as social scientists, philosophers, legal scholars and industry practitioners. Reflecting this diversity of perspectives, different approaches to AI auditing have different affordances and constraints. Specifically, a distinction can be made between technology-oriented audits, which focus on the properties and capabilities of AI systems, and process-oriented audits, which focus on technology providers’ governance structures and quality management systems. The next step in the evolution of auditing as an AI governance mechanism, this article concludes, should be the interlinking of these available—and complementary—approaches into structured and holistic procedures to audit not only how AI systems are designed and used but also how they impact users, societies and the natural environment in applied settings over time.
An Experimental High-Throughput to High-Fidelity Study Towards Discovering Al–Cr Containing Corrosion-Resistant Compositionally Complex Alloys
Authors: Sur Debashish , Holcombe Emily F. , Blades William H. , Anber Elaf A. , Foley Daniel L. , DeCost Brian L. , Liu Jing , Hattrick-Simpers Jason , Sieradzki Karl , Joress Howie , Scully John R. , Taheri Mitra L. 
Published: November 2023

AbstractCompositionally complex alloys hold the promise of simultaneously attaining superior combinations of properties, such as corrosion resistance, light-weighting, and strength. Achieving this goal is a challenge due in part to a large number of possible compositions and structures in the vast alloy design space. High-throughput methods offer a path forward, but a strong connection between the synthesis of an alloy of a given composition and structure with its properties has not been fully realized to date. Here, we present the rapid identification of corrosion-resistant alloys based on combinations of Al and Cr in a base Al–Co–Cr–Fe–Ni alloy. Previously unstudied alloy stoichiometries were identified using a combination of high-throughput experimental screening coupled with key metallurgical and electrochemical corrosion tests, identifying alloys with excellent passivation behavior. The alloy native oxide performance and its self-healing attributes were probed using rapid tests in deaerated 0.1-mol/L H2SO4. Importantly, a correlation was found between the electrochemical impedance modulus of the exposure-modified air-formed film and self-healing rate of the CCAs. Multi-element extended x-ray absorption fine structure analyses connected more ordered type chemical short-range order in the Ni–Al 1st nearest-neighbor shell to poorer corrosion resistance. This report underscores the utility of high-throughput exploration of compositionally complex alloys for the identification and rapid screening of a vast stoichiometric space.
Graphical Abstract
Difference between days of therapy and days of antibiotic spectrum coverage in an inpatient antimicrobial stewardship program: Vector autoregressive models for time-series analysis
Authors: Murakami Shutaro , Akazawa Manabu , Honda Hitoshi 
Published: November 2023

AbstractObjective:The days of therapy (DOT) metric, used to estimate antimicrobial consumption, has some limitations. Days of antibiotic spectrum coverage (DASC), a novel metric, overcomes these limitations. We examined the difference between these 2 metrics of inpatient intravenous antimicrobial consumption in assessing antimicrobial stewardship efficacy and antimicrobial resistance using vector autoregressive (VAR) models with time-series analysis.Methods:Differences between DOT and DASC were investigated at a tertiary-care center over 8 years using VAR models with 3 variables in the following order: (1) the monthly proportion of prospective audit and feedback (PAF) acceptance as an index of antimicrobial stewardship efficacy; (2) monthly DOT and DASC adjusted by 1,000 days present as indices of antimicrobial consumption; and (3) the monthly incidence of 5 organisms as an index of antimicrobial resistance.Results:The Granger causality test, which evaluates whether incorporating lagged variables can help predict other variables, showed that PAF activity contributed to DOT and DASC, which, in turn, contributed to the incidence of drug-resistant P. aeruginosa. Notably, only DASC helped predict the incidence of drug-resistant Enterobacterales. Another VAR analysis demonstrated that a high proportion of PAF acceptance was accompanied by decreased DASC in a given month, whereas increased DASC was accompanied by an increased incidence of drug-resistant Enterobacterales, unlike with DOT.Conclusions:The VAR models of PAF activity, antimicrobial consumption, and antimicrobial resistance suggested that DASC may more accurately reflect the impact of PAF on antimicrobial consumption and be superior to DOT for predicting the incidence of drug-resistant Enterobacterales.
Health Outcomes among the Frail Elderly in Communities and Institutions: Use of The Minimum Data Set (MDS) to Create Effective Linkages between Research and Policy
Authors: Hirdes John P. , Carpenter G. Iain 
Published: November 2023

AbstractResearchers and policy-makers interested in the needs of the frail elderly in community and institutional settings have had limited success in forming policy based on empirical evidence. The reasons for this have included a variety of organizational and political considerations (e.g., lack of effective communication mechanisms), conceptual and methodological issues (e.g., problems with reliability and validity of existing data sources) and limitations in knowledge (e.g., lack of longitudinal data across health care sectors). The Minimum Data Set (MDS) series of instruments may prove useful in dealing with these difficulties. The MDS instruments have multiple uses for different audiences (e.g., care provision, funding and quality improvement). Extensive international testing has shown the MDS to be valid and reliable, and translations are available in 11 different languages. As implementation of the MDS begins in Canada, a number of new concerns will need to be addressed (e.g., confidentiality and access to data).
Using a Participatory Research Process to Make a Difference in Policy on Aging
Authors: McWilliam Carol L. 
Published: November 2023

AbstractAs policy emerges from the interplay of economic, political, and social forces, determining whether research has made a difference to policy choices on aging issues is extremely difficult. Such a determination demands attention to the "black box" of the policy process, and the setting within which policy ultimately operates. This paper presents a Seniors' Independence Research Program as a case illustration of how research has made a difference to policy choices by stakeholder involvement throughout the research process. Strategies ensure stakeholder collaboration in policy issue search, filtration, definition, and prioritization; involvement in the design, implementation, and evaluation of health services models; and participation in achieving long-term evidence-based changes in policy and practice.
Seniors’ Views of Medication Reimbursement Policies: Bridging Research and Policy at the Point of Policy Impact
Authors: Chappell Neena L. , Maclure Malcolm , Brunt Howard , Hopkinson Jennifer , Mullett Jennifer 
Published: November 2023

AbstractEscalating medication prices are forcing drug benefit programs worldwide to change their payment policies. Physicians object that this intrudes on their long established authority to prescribe medications they judge best for their patients. This paper reports data from focus groups and a large random sample of seniors in British Columbia who were asked for their views towards Pharmacare's reference based pricing (RBP) policy. Seniors expressed the desire for physicians to be more knowledgeable and more involved in all aspects of medical care including policy changes. They have confidence in physicians as a credible source of information, but they also have as much confidence in pharmacists and almost as much in the Ministry of Health. Seniors overwhelmingly accept, and the majority support government's efforts with their cost-saving Pharmacare policies. Furthermore, those who know more about the policy are more likely to support it. The paper closes with a discussion of the feedback process with decision-makers.
Linear quadratic approximation of rationally inattentive control problems
Authors: Miao Jianjun , Zhang Bo 
Published: November 2023

AbstractThis paper proposes a linear quadratic approximation approach to dynamic nonlinear rationally inattentive control problems with multiple states and multiple controls. An efficient toolbox to implement this approach is provided. Applying this toolbox to five economic examples demonstrates that rational inattention can help explain the comovement puzzle in the macroeconomics literature.
A Link Between Hydroclimate Variability and Biomass Burning During the Last Millennium in the Interior Pacific Northwest
Authors: Mark S. Z. , Abbott M. B. , Steinman B. A. , Fernandez A. , Wise E. K. , Walsh M. K. , Whitlock C. 
Published: November 2023

AbstractWe present oxygen isotope and charcoal accumulation records from two lakes in eastern Washington that have sufficient temporal resolution to quantitatively compare with tree‐ring records and meteorological data. Hydroclimate reconstructions from tree‐rings and lake sediments show close correspondence after accounting for seasonal‐ to centennial‐ scale temporal sensitivities. Carbonate δ18O measurements from Castor and Round lakes reveal that the Medieval Climate Anomaly (MCA) experienced wetter November‐March conditions than the Little Ice Age (LIA). Charcoal records from Castor, Round, and nearby lakes show elevated fire activity during the LIA compared to the MCA. Increased multidecadal hydroclimate variability after 1250 CE is evident in proxy records throughout western North America. In the Upper Columbia River Basin, multidecadal wet periods during the LIA may have enhanced fuel loads that burned in subsequent dry periods. A notable decline in biomass burning occurred with Euro‐American settlement in the late nineteenth century.
How Sea Level Rise May Hit You Through the Backdoor: Changing Extreme Water Levels in Shallow Coastal Lagoons
Authors: Lorenz Marvin , Arns Arne , Gräwe Ulf 
Published: November 2023

AbstractDue to their choked geometry, coastal lagoons can attenuate extreme water levels compared to the open sea. However, this protective property is expected to decrease due to sea‐level rise. By studying idealized lagoons in a non‐dimensional parameter space, this study describes non‐linear interactions between tides, storm surges, freshwater fluxes into the lagoon, and sea‐level rise. The non‐dimensional numbers include lagoon geometry and forcing scales. The main objective is to provide an overview of potentially affected lagoons and to highlight the importance of attenuation changes due to sea‐level rise. Tidal and storm surge induced maximum water levels inside lagoons rise faster than sea‐level rise for most of the parameter space. Maximum water levels due to freshwater fluxes rise slower than sea‐level rise for strongly choked lagoons. For compound events, the response between rising faster or slower than sea‐level rise depends strongly on the lagoon geometry.
Astronomical Pacing of Middle Eocene Sea‐Level Fluctuations: Inferences From Shallow‐Water Carbonate Ramp Deposits
Authors: Brachert T. C. , Agnini C. , Gagnaison C. , Gély J.‐P. , Henehan M. J. , Westerhold T. 
Published: November 2023

AbstractAstrochronologically calibrated deep‐sea records document the Cenozoic (66–0 Ma) global climatic cooling in great detail, but the magnitude of sea‐level fluctuations of the middle Eocene Warmhouse state (47.8–37.7 Ma) and the ∼40.3 Ma warming event of the Middle Eocene Climatic Optimum (MECO) is not well constrained. Here, we present a sequence stratigraphic classification of a shallow marine mixed carbonate—clastic ramp system for this time interval in Paris basin, France. Based on sedimentologic, paleogeographic and biostratigraphic data, we hypothesize that the 22 elementary sequences recognized each correspond to the long cycle of orbital eccentricity (0.405 Myr). With the exception of the MECO, the shoreline trajectory of superimposed, third‐order depositional sequences evolved in phase with the very long cycles of orbital eccentricity (2.4 Myr), suggesting significant polar ice build‐up leading to sea level lowstands during nodes of the very long eccentricity cycle. Inferred from Fischer Plot methodology, Lutetian third‐order eustasy was in the order of 5–10 m and during the MECO 30 m or more. Furthermore, the shallow‐water record implies that third order sea‐level changes were astronomically paced in the middle Eocene Warmhouse climate state, but a decoupling occurred during the transient MECO warming.
Improving the accuracy of blood pressure measuring devices in Australia: a modelled return on investment study
Authors: Desson Zachary , Sharman James E. , Searles Andrew , Schutte Aletta E. , Delles Christian , Olsen Michael Hecht , Ordunez Pedro , Hure Alexis , Morton Rachael , Figtree Gemma , Webster Jacqui , Jennings Garry , Redfern Julie , Nicholls Stephen J. , McNamara Martin , Deeming Simon , Doyle Kerry , Ramanathan Shanthi 
Published: November 2023

AbstractThe VALID BP project was initiated to increase the availability of validated blood pressure measuring devices (BPMDs). The goal is to eliminate non validated BPMDs and minimise over- and underdiagnosis of hypertension caused by inaccurate readings. This study was undertaken to assess the potential return on investment in the VALID BP project. The Framework to Assess the Impact of Translational Health Research was applied to the VALID BP project. This paper focuses on the implementation of the cost benefit analysis aspect of this framework to monetise past research investment and model future research costs, implementation costs, and benefits. Analysis was based on reasoned assumptions about potential impacts from availability and use of validated BPMDs (assuming an end goal of 100% validated BPMDs available in Australia by 2028) and improved skills leading to more accurate BP measurement. After 5 years, with 20% attribution of benefits, there is a potential $1.14–$1.30 return for every dollar spent if the proportion of validated BPMDs and staff trained in proper BP measurement technique increased from 20% to 60%. After eight years (2020–2028) and assuming universal validation and training coverage, the returns would be between $2.70 and $3.20 per dollar spent (not including cost of side effects of unnecessary medication or downstream patient impacts from unmanaged hypertension). This modelled economic analysis indicates there will be positive downstream economic benefits if the availability of validated BPMDs is increased. The findings support ongoing efforts toward a universal regulatory framework for BPMDs and can be considered within more detailed future economic analyses.
Comparison of various vasopressin doses to epinephrine during cardiopulmonary resuscitation in asphyxiated neonatal piglets
Authors: Ramsie Marwa , Cheung Po-Yin , Lee Tze-Fun , O’Reilly Megan , Schmölzer Georg M. 
Published: November 2023

Abstract
Background
Current neonatal resuscitation guidelines recommend epinephrine for cardiac arrest. Vasopressin might be an alternative during asphyxial cardiac arrest. We aimed to compare vasopressin and epinephrine on incidence and time to return of spontaneous circulation (ROSC) in asphyxiated newborn piglets.

Design/methods
Newborn piglets (n = 8/group) were anesthetized, intubated, instrumented, and exposed to 30 min of normocapnic hypoxia, followed by asphyxia and asystolic cardiac arrest. Piglets were randomized to 0.2, 0.4, or 0.8IU/kg vasopressin, or 0.02 mg/kg epinephrine. Hemodynamic parameters were continuously measured.

Results
Median (IQR) time to ROSC was 172(103–418)s, 157(100–413)s, 122(93–289)s, and 276(117–480)s for 0.2, 0.4, 0.8IU/kg vasopressin, and 0.02 mg/kg epinephrine groups, respectively (p = 0.59). The number of piglets that achieved ROSC was 6(75%), 6(75%), 7(88%), and 5(63%) for 0.2, 0.4, 0.8IU/kg vasopressin, and 0.02 mg/kg epinephrine, respectively (p = 0.94). The epinephrine group had a 60% (3/5) rate of post-ROSC survival compared to 83% (5/6), 83% (5/6), and 57% (4/7) in the 0.2, 0.4, and 0.8IU/kg vasopressin groups, respectively (p = 0.61).

Conclusion
Time to and incidence of ROSC were not different between all vasopressin dosages and epinephrine. However, non-significantly lower time to ROSC and higher post-ROSC survival in vasopressin groups warrant further investigation.

Impact

Time to and incidence of ROSC were not statistically different between all vasopressin dosages and epinephrine.

Non-significantly lower time to ROSC and higher post-ROSC survival in vasopressin-treated piglets.

Overall poorer hemodynamic recovery following ROSC in epinephrine piglets compared to vasopressin groups.

Human neonatal clinical trials examining the efficacy of vasopressin during asphyxial cardiac arrest will begin recruitment soon.
Long-term spaceflight composite stress induces depression and cognitive impairment in astronauts—insights from neuroplasticity
Authors: Yin Yishu , Liu Junlian , Fan Quanchun , Zhao Shuang , Wu Xiaorui , Wang Jiaping , Liu Yu , Li Yongzhi , Lu Weihong 
Published: November 2023

AbstractThe environment on the space station is quite unique compared to Earth, which is a composite of multiple stressors, such as microgravity, isolation, confinement, noise, circadian rhythm disturbance, and so on. During prolonged space missions, astronauts have to stay in such extreme environments for long periods, which could induce adverse effects on both their physical and mental health. In some circumstances, this kind of long-term spaceflight composite stress (LSCS) could also induce depression and cognitive impairment in various ways, including dysregulating the neuroplasticity of the brains of astronauts, which should be attached to great importance. Here, we have comprehensively reviewed the impact of individual and combined stressors on depression and cognitive function during long-term spaceflight, explained the underlying mechanisms of those effects from the perspective of neuroplasticity, and current countermeasures for mitigating these challenges. This review provides insights into LSCS and potential neuroplasticity mechanisms, current with potentially great impact for understanding and mitigating the mental health risks and traumas of career astronauts and space tourists.
Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells
Authors: Chrisochoidou Yakinthi , Roy Rajat , Farahmand Pooyeh , Gonzalez Guadalupe , Doig Jennifer , Krasny Lukas , Rimmer Ella F. , Willis Anne E , MacFarlane Marion , Huang Paul H. , Carragher Neil O. , Munro Alison F. , Murphy Daniel J. , Veselkov Kirill , Seckl Michael J. , Moffatt Miriam F. , Cookson William O. C. , Pardo Olivier E. 
Published: November 2023

AbstractMesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive fibrotic response. The latter is in large part mediated by cancer-associated fibroblasts which mediate tumour progression and poor prognosis. However, understanding of the crosstalk between cancer cells and fibroblasts in this disease is mostly lacking. Here, using co-cultures of patient-derived mesothelioma cell lines and lung fibroblasts, we demonstrate that fibroblast activation is a self-propagated process producing a fibrotic extracellular matrix (ECM) and triggering drug resistance in mesothelioma cells. Following characterisation of mesothelioma cells/fibroblasts signalling crosstalk, we identify several FDA-approved targeted therapies as far more potent than standard-of-care Cisplatin/Pemetrexed in ECM-embedded co-culture spheroid models. In particular, the SRC family kinase inhibitor, Saracatinib, extends overall survival well beyond standard-of-care in a mesothelioma genetically-engineered mouse model. In short, we lay the foundation for the rational design of novel therapeutic strategies targeting mesothelioma/fibroblast communication for the treatment of mesothelioma patients.