bluuebunny/crossref_metadata_2025_split huggingface dataset:
La motricité au cœur des troubles du neuro développement de l’enfant
Authors: Barbu-Roth Marianne 
Published: December 2023

Les compétences motrices d’un enfant jouent un rôle prépondérant à tous les niveaux de son développement et tout déficit moteur peut non seulement impacter la fonction motrice elle-même, mais enclencher des anomalies en cascades sur le développement des coordinations visuo-motrices, de l’orientation spatiale, du langage, des interactions sociales, de l’attention visuelle conjointe et de la construction des émotions de l’enfant. Cette question est particulièrement sensible chez les nourrissons pour lesquels il existe un risque accru d’anomalie neuromotrice, allant du déficit sensorimoteur mineur aux troubles du neuro développement. Cette introduction fait le point sur les raisons pour lesquelles le rôle de la motricité est encore souvent sous-estimé dans la communauté scientifique et décline les arguments pour diagnostiquer, prévenir et intervenir le plus précocement possible chez des enfants à risque de déficit moteur. En s’appuyant sur l’expertise d’Evelyne Soyez-Papiernik, kinésithérapeute et ostéopathe spécialiste de ces questions, plusieurs recommandations sont développées afin d’améliorer le diagnostic et la prise en charge des enfants à risque de handicap. Ces recommandations insistent en particulier 1) sur la nécessité de distinguer entre un problème moteur lié à un schéma musculosquelettique déficient et un problème moteur lié à un possible trouble du neuro développement et 2) sur l’intérêt d’utiliser des méthodes dédiées pour placer l’enfant dans un contexte maximal pour évaluer sa motricité. Ces recommandations mettent en lumière l’importance d’avoir une approche multidisciplinaire, en particulier avec une expertise en neuro pédiatrie et en anatomie du corps en mouvement, pour évaluer un trouble de la motricité.
Du prétoire à l’espace médiatique. Les procès des Einsatzgruppen (1958), de Majdanek (1975-1981) et d’Oskar Gröning (2015) dans la juridiction et les médias allemands
Authors: Zunino Bérénice 
Published: December 2023

L’histoire médiatique des procès complète l’histoire du droit en ce qu’elle permet d’examiner la réception des procès et de leur jurisprudence dans l’espace public. Parmi les procès pénaux qui ont posé tant de problèmes à la justice fédérale, trois d’entre eux ont joué un rôle clé ; celui des Einsatzgruppen , dont la « jurisprudence des complices » a été étonnamment peu discutée dans les médias ; celui de Majdanek, qui, malgré une réception plus critique, confirma cette jurisprudence ; et celui de Gröning. Bien qu’il favorisât des avancées juridiques tardives et une maîtrise de la « maîtrise du passé » dans l’espace médiatique, ce procès est resté en deçà de l’examen critique que l’on aurait pu attendre de la part de la justice, révélant un décalage entre vérité judiciaire et prégnance du passé nazi dans la mémoire collective allemande aujourd’hui.
Féminin et maternel : déliaisons dangereuses
Authors: Viard Véronique , Carton Solange 
Published: December 2023

La réactivation aiguë du pulsionnel infantile pendant la période périnatale produit également des effets durables dans la relation mère-enfant tout au long de la vie. Ces effets touchent aux assises du féminin de la femme, susceptible de n’être pas suffisamment intégré dans le maternel et de donner lieu à des déliaisons ouvrant à des dérives pathologiques. Cet article s’intéresse aux difficultés de traitement psychique de « l’excès pulsionnel » propre au maternel, lorsque l’actualisation du sexuel infantile a nécessité l’usage de défenses répressives drastiques, entravant l’accueil et l’élaboration du pulsionnel chez la mère et chez l’enfant.
Role of 99mTc-sestamibi Scintimammography in Predicting Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer: A Prospective Study
Authors: Moulika Jeepalem Sai , Kalawat Tekchand , Manthri Ranadheer Gupta , Hulikal Narendra , Kadiyala Silpa , Bhargavi D. , Prayaga Aruna Kumari 
Published: December 2023

Background:
Neoadjuvant chemotherapy (NACT) is the first line of management for locally advanced breast cancer (LABC). However, chemoresistance is prevalent in 18%–50% of the cases. One of the important and most studied causes of chemoresistance is P-glycoprotein (Pgp) expression. 99mTc-sestamibi scintimammography may serve as a useful imaging tool to predict Pgp expression, thereby response to NACT.

Aim:
The aim was to study the role of 99mTc-sestamibi scintimammography in predicting response to NACT in treatment-naive, biopsy-proven LABC patients.

Materials and Methods:

99mTc-sestamibi scintimammography (early and delayed images) was performed on a total of 34 patients. Eight patients were lost to follow-up, and only 26 (25 females and 1 male) patients were available for final analysis, with a mean age of 49.7 ± 10.7 years. 99mTc-sestamibi washout rate (WOR) (%) and T/B buildup were calculated. Pre-NACT and Post-NACT tumor sizes were measured clinically, and a % decrease in tumor size was calculated. The WOR and T/B buildup values were correlated with the % decrease in tumor size.

Results:
We found a statistically significant negative correlation between WOR (%) and % decrease in tumor size and a statistically significant positive correlation between T/B buildup and % decrease in tumor size. Furthermore, we found a positive correlation between the early T/B ratio and the Ki-67 index (P = 0.22).

Conclusion:
Early categorization of responders and nonresponders can help in optimal therapy planning. 99mTc-sestamibi scintimammography can serve as an imaging marker for Pgp expression, thereby predicting clinical response to NACT in LABC patients. Further studies with larger sample sizes are warranted to consolidate the above findings.
Effectiveness of Head-and-Neck Molecular Imaging Reporting and Data System Criterion in Head-and-Neck Squamous Cell Carcinoma PostConcurrent Chemoradiotherapy
Authors: Gupta Manoj , Jajodia Ankush , Ahlawat Parveen , Gairola Munish , Agarwal Mudit , Goyal Sumit , Mehta Parv , Choudhury Partha Sarathi 
Published: December 2023

Purpose:
Postconcurrent chemoradiotherapy (CRT) response assessment has been challenging in locally advanced head-and-neck squamous cell carcinoma (LA-HNSCC) due to prevailing postradiation changes. Molecular response methods have been encouraging, although further clarifications and validations were needed. We tested the effectiveness of a proposed semi-quantitative molecular response criterion in these patients.

Materials and Methods:
Two subspecialty-trained physicians evaluated 18F-fluorodeoxyglucose positron emission tomography/computed tomography of LA-HNSCC patients (n = 83) post 3 months CRT using a five points Head and Neck Molecular Imaging-Reporting and Data System (HAN-MI-RADS) criterion. Where available, histopathology examination with clinical and imaging interpretation was taken as a reference for the disease. A diagnostic accuracy comparison was done with the existing Hopkins score. Further effectiveness was analyzed with disease-free survival (DFI) and overall survival (OS).

Results:
Metastasis was developed in 11/83 patients at 3 months of evaluation. Of 72 patients, 39, 2, and 31 patients had a complete response, equivocal response, and partial response as per HAN-MI-RADS. Per patient sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for predicting loco-regional disease up to 1 and 2 years was 93.3%, 92.5%, 90.3%, 94.9%, 92.9%, and 84.9%, 91.9%, 90.3%, 87.2%, and 88.6% respectively. One year and two years DFI for each HAN-MI-RADS score showed a statistically significant difference while it was not for OS. The receiver operating characteristic curve analysis showed significantly better outcome predictability of HAN-MI-RADS (area under the curve [AUC] 0.884) than Hopkins (AUC 0.699).

Conclusions:
A five points HAN-MI-RADS criterion was found promising for response assessment with less equivocal results and statistically significant higher AUC than Hopkins for loco-regional recurrence prediction.
Evaluation of Pendrin Expression Using Nuclear Imaging Modalities and Immunohistochemistry in Animal Thyroid Cancer Model
Authors: Gholve Chandrakala Sanjay , Shete Yogita , Rakshit Sutapa , Kulkarni Savita 
Published: December 2023

Context:
The impaired ability of thyroid cancer (TC) cells to uptake and concentrate iodine represents a major therapeutic challenge in malignant TC management. This has been reported probably due to reduced or loss of expression of pendrin in thyroid tumors.

Aims:
In view of this, we evaluated the pendrin expression in the chemically induced (using N-bis[2-hydroxypropyl] nitrosamine [DHPN]) TC model in Wistar rats.

Methods:
Uptake in the thyroid gland was evaluated by positron emission tomography with computed tomography (PET-CT) and scintigraphy imaging. Further histopathology (HP) and immunohistochemistry (IHC) were performed for confirming malignancy.

Results:
The altered uptake in the thyroid gland was observed by PET-CT and scintigraphy imaging. Significant pathological changes in the thyroid were observed using 2-deoxy-2-(fluorine-18) fluoro-D-glucose PET-CT, technetium-99m pertechnetate imaging, and reduced iodine-131 uptake (n = 4) in DHPN-induced animals compared to control indicative of thyroid cell proliferation. In treated groups, tissue HP revealed hyperplastic follicular to papillary cell proliferation with variable mitotic activity. The malignant nature of the tissue and variable uptake of the tracer were further reconfirmed by IHC. IHC revealed reduced pendrin expression in malignant thyroid tissue.

Conclusions:
Hence, nuclear imaging techniques can be of aid in the early identification and evaluation of cellular changes during the early development of tumor models in laboratory animals. In conclusion, our study reveals that pendrin expression plays a vital role in thyroid uptake, and its reduction was observed in TC in a chemically induced TC model.
Comparison of Diagnostic Value between 99mTechnetium-Methylene Diphosphate Bone Scan and 99mTechnetium-Prostate-specific Membrane Antigen Scan in Patients with Prostate Cancer with Osseous Metastases
Authors: Alemi Mohsen , Banouei Farshad , Ahmadi Reyhaneh 
Published: December 2023

Background:
Prostate cancer (PCa) ranks as the second most prevalent cancer among men globally. The utilization of efficient and cost-effective diagnostic and therapeutic approaches holds paramount importance in the diagnosis and treatment of these patients, significantly impacting treatment outcomes. This study focuses on the investigation and comparison of two commonly employed scans within the treatment process for these patients.

Methods:
In this prospective study, which spanned over 2 years, 40 patients diagnosed with PCa underwent examination using two scans: 99m Technetium-Prostate-specific Membrane Antigen (99mTC-PSMA) Scan and between Technetium-Methylene Diphosphate (99mTC-MDP) Bone Scan. The findings of these scans were then compared with each other, as well as with the results obtained from magnetic resonance imaging and the prostate-specific antigen level. The analysis of the results was conducted utilizing SPSS 22 software, and descriptive statistical methods were employed to present the findings.

Results:
In this prospective study, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the 99mTC-MDP Bone Scan were found to be 88.2%, 83.3%, 96.7%, 55.5%, and 87.5%, respectively. Similarly, for the 99mTC-PSMA Scan, the corresponding values were 94.1%, 83.3%, 96.4%, 83.3%, and 92.5%, respectively.

Conclusions:
Based on the findings of this study, it can be concluded that the diagnostic accuracy of the 99mTC-PSMA Scan is marginally higher compared to the 99mTC-MDP Bone Scan. Therefore, for patients who are limited to only one scan, the 99mTC-PSMA Scan appears to be the preferable choice.
Managing complications in Charcot neuroarthropathy: A case report on hindfoot nailing and peri-implant fractures
Authors: Moonot Pradeep , Reddy Santhosh Chandra , Dakhode Shubham Yashwant 
Published: December 2023

Abstract
Charcot neuroarthropathy (CN) is a serious complication of diabetes, causing foot bone and joint damage. Hindfoot nail surgery is a common procedure for hindfoot Charcot arthropathy. However, postsurgical complications can occur due to inadequate planning. This case report discusses one such postsurgical uncommon complication in the management of a hind foot CN with a hind foot nail. A 50-year-old patient with severe diabetes presented with hindfoot issues, leading to a CN (diagnosis). A two-stage surgical approach, involving an external fixator and later a tibiotalocalcaneal nail, was initially pursued. However, a peri-implant fracture occurred, prompting a revision surgery with a longer nail insertion, ultimately resulting in successful postoperative healing and hindfoot fusion. The management of hind foot CN in diabetic patients can be complex. This case report highlights a postsurgical complication, a peri-implant fracture, which required revision surgery with a longer nail for successful healing. Meticulous planning, vigilant postoperative monitoring, and longer nails that cross the pin tract site can help to avoid such complications.
Validation of a Risk Stratification Tool among Full-term Neonates with Suspicion of Invasive Bacterial Infections
Authors: Almalki Faisal Ghazi , Alhindi Mohammed Yasir , Alwarthan Abdulaziz Abdulrahman , Alharbi Sulaiman Ahmed , Alharthi Yasser Ali , AlZaid Ahmed Abdullatif , Khan Rayan Ayoub , Abed Sara Seraj , AlQurashi Mansour Abdullah 
Published: December 2023

Context:
The emergence of neonatal invasive bacterial infections (IBIs) poses a formidable challenge to health-care providers worldwide. The combination of nonspecific clinical symptoms, in addition to the absence of an acceptable sensitive test, resembles a dilemma for clinicians to diagnose or safely rule out the presence of infections. A newly developed tool by Chen et
al. stratifies the risk of full-term neonates suspected of IBI. This model works by identifying neonates who need immediate antibiotic treatment from those who only need observational and continuous reassessment.

Aims:
The purpose of the study was to validate Chen et
al.’s risk stratification tool.

Settings and Design:
This is a retrospective cohort study.

Subjects and Methods:
The following parameters are required to utilize this tool: ill appearance, abnormal neurological signs, age at admission, white blood cell, neutrophil percentage, C-reactive protein, and procalcitonin (PCT).

Statistical Analysis Used:
Data management and analysis were carried out using SPSS version 25.

Results:
Out of 768 neonates screened for IBIs, we identified 100 babies suspected of IBI regardless of PCT availability. Out of those, 30 neonates were eligible to be entered into the calculator and used for the validation process. The number of neonates who had IBIs was found to be 14 babies. Neonatal IBI incidence in full-term babies was estimated to be 0.79/1000 live births. Specificity, negative predictive value, and accuracy of the validated tool were reported as 82.14% (95% confidence interval [CI]: 63.11%–93.94%), 99.9% (95% CI: 99.88%–99.91%), and 82.07% (95% CI: 63.81%–93.59%), respectively.

Conclusions:
Overall, the tool demonstrated a poor outcome in terms of detecting those with IBI but excellent outcomes in identifying healthy babies.
Remineralising potential of Ocimum basilicum varnish and fluoride varnish on initial enamel caries: An in vitro microscopic study
Authors: Pai Khot Atrey J. , Ankola Anil V. , Naik Veena V. , Sankeshwari Roopali M. , Kumar Ram Surath , Shah Mehul A. 
Published: December 2023

Background:
The focus of caries research has switched to early identification and non-invasive treatment of carious lesions.

Aim:
This study aimed to evaluate and compare the remineralising potential of Ocimum (O.) basilicum varnish and fluoride varnish on initial enamel caries.

Method:
The authenticated O. basilicum seeds were procured from a repository, and the extract was prepared using the Soxhlet method, which was vortexed with Indian Pharmaceutical (IP)-graded chemicals to obtain varnish. Extracted premolar tooth samples were divided into three groups of 33 each after demineralisation with a pH of 4.5 for 48 hours at 37°C. Each group was subjected to remineralisation twice daily with respective agents for 4 minutes for 30 consecutive days. Each sample was ground-sectioned through an enamel window. The lesion depth was measured using a light microscope (Leica™ DM2500) and ImageJ software. The data were evaluated using analysis of variance (ANOVA) and post hoc analysis.

Results:
The mean (± SD) pre-treatment lesion depth across the groups ranged from 242.11 ± 26.144 μm to 352.66 ± 34.531 μm. The highest lesion depth recovery rate of 45.938% was recorded for the fluoride varnish group, followed by 36.015% in the O. basilicum varnish group, which was statistically significant by Tukey’s post hoc analysis (p < 0.001). The gingival fibroblast cells were viable by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay.

Conclusion:
The O. basilicum varnish demonstrated a homogenous layer of mineral deposition. However, the remineralising efficacy was slightly lesser than that of the fluoride varnish. Hence, the novel O. basilicum-based remineralisation agent appears to have potential as a non-invasive alternative to topical fluorides in the therapy of early caries lesions.
Is diabetes a real susceptibility for SARS-CoV-2 oral manifestation?
Authors: Smitha T. , Thomas Anela 
Published: December 2023

Background:
Furin, a polybasic cleavage enzyme, is increasingly recognized in the pathogenesis of metabolic syndromes like diabetes. Its cleavage action is an essential activation step for the SARS-CoV-2 attachment site at the junction of S1 and S2, the two subunits of the spike. This allows effective cleavage by furin and has a role in determining viral infectivity and host range. The increased expression of the furin enzyme in the saliva is remarkable enough to be noted as a susceptibility factor for diabetic patients.

Aim of the Study:
The present study focuses on the qualitative assessment of the furin enzyme through an immunological ELISA test.

Materials and Methods Used:
The study consisted of three groups, each of whom was a COVID-19 recovered patient (n = 20), a diabetic patient (n = 20), and a healthy patient (n = 20).

Result:
The study assessed significantly increased levels of the furin enzyme generally in diabetic patients and COVID-19 recovered patients as compared to the healthy control group.

Conclusion:
The estimation of furin in saliva still holds the possibility of being a prognostic marker in many COVID-19 infected patients. Further evidence-based studies are required to establish the same.
A multicentric case study of fibroblastic and myofibroblastic oral spindle cell lesions
Authors: Jot Kiran , Nayyar Vivek , Surya Varun , Mishra Deepika , Sowmya SV , Augustine Dominic , Indu M , Haragannavar Vanishri C. 
Published: December 2023

Context:
Spindle cell lesions comprise a vast plethora of benign and malignant lesions with similar clinical and radiographic features. Their overlapping histopathologic features ensure a diagnostic dilemma.

Aim:
The current multicentric study aims to delineate fibroblastic and myofibroblastic oral spindle cell lesions based on cytomorphology and comprehensive immunohistochemical analysis.

Settings and Design:
The experimental study was conducted at MS Ramaiah University of Applied Sciences, Bangalore, and All India Institute of Applied Sciences, Delhi.

Methods and Material:
A comprehensive histological scoring criteria and panel of immunohistochemical makers (STAT6, CD31, CD34, S100, SMA, vimentin, pan-CK, HHF-35, Ki67, ALK, desmin, HMB-45, SATB2, ERG, EMA and CD99) were employed concurrently for the first time for fibroblastic and myofibroblastic oral spindle cell lesions. The data obtained was tabulated and studied.

Statistical Analysis Used:

NA. Results: Using cytological scoring criteria and panel of immunohistochemical makers, the cases analysed and characterized were desmoplastic fibroma, fibrosarcoma, leiomyosarcoma, nodular fasciitis, neurofibroma and epithelioid inflammatory myofibroblastic sarcoma (EIMS).

Conclusions:
The diagnostic strategies need to be upgraded for the diagnosis of spindle cell lesions. Emphasis must be placed on cytomorphology, an immunohistochemistry (IHC) panel of markers is imperative for the accurate diagnosis of fibroblastic and myofibroblastic oral spindle cell lesions.
Comparison of the effectiveness of red ginseng herbal mouth rinse with chlorhexidine and saline in oral cancer patients: A pilot double-blinded randomized control trial
Authors: Jeddy Nadeem , Saravanan R. , Natrajan RajVikram , Sai Lakshmi L. J. , Ashwath V. , Singhal Ishita 
Published: December 2023

Background:
Red ginseng is an herb with many medicinal properties and aids as a mouth rinse with fewer side effects than chlorhexidine.

Aim:
The study aimed to compare the efficacy of red ginseng herbal mouth rinses with those of chlorhexidine and saline in oral cancer patients.

Materials and Methods:
The present pilot study was a double-blinded randomized control trial with 45 histopathologically diagnosed oral squamous cell carcinoma patients divided into three groups: two intervention groups (herbal and chlorhexidine mouth rinse) and one control group (saline). Saliva samples for each patient were collected at baseline and after 14 days of using the mouth rinses. A microbiological examination of salivary samples was done by analysing total oral bacterial load along with specific counts for Porphyromonas gingivalis and Fusobacterium nucleatum at baseline and after the usage of mouth rinse.

Statistical Analysis:
The data normality was analysed using the Shapiro–Wilk test, and following the normal distribution of data, parametric tests were employed. Paired t-test and one-way analysis of variance, followed by post hoc Bonferroni test, were used for inter-group and intra-group differences.

Result:
There was a significant mean difference in total colony count, Fusobacterium nucleatum, and Porphyromonas gingivalis with oral hygiene index and gingival index improvement in the red ginseng herbal mouth rinse group when compared to the chlorhexidine and saline groups.

Conclusion:
In this study, red ginseng mouth rinse exhibited an increased antibacterial effect compared to chlorhexidine and saline. Hence, red ginseng mouth rinse can be used in oral cancer patients to maintain oral health, thereby improving the prognosis of these patients.