bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in bone histomorphometry between White postmenopausal women with and without atypical femoral fracture after long-term bisphosphonate therapy
Authors: Qiu Shijing , Dhaliwal Ruban , Divine George , Warner Elizabeth , Rao Sudhaker D 
Published: February 2024

Abstract
Bone histomorphometric endpoints in transilial biopsies may be associated with an increased risk of atypical femoral fracture (AFF) in patients with osteoporosis who take antiresorptives, including bisphosphonates (BPs). One way to test this hypothesis is to evaluate bone histomorphometric endpoints in age-, gender-, and treatment time-matched patients who either had AFF or did not have AFF. In this study, we performed transiliac bone biopsies in 52 White postmenopausal women with (n = 20) and without (n = 32) AFFs, all of whom had been treated for osteoporosis continuously with alendronate for 4–17 yr. Despite the matched range of treatment duration (4–17 yr), AFF patients received alendronate for significantly longer time (10.7 yr) than non-AFF patients (8.0 yr) (P = .014). Bone histomorphometric endpoints reflecting microstructure and turnover were assessed in cancellous, intracortical, and endocortical envelopes from transilial biopsy specimens obtained from BP-treated patients 3–6 mo after AFF and from non-AFF patients with similar age-, gender-, and range of BP treatment duration. However, in both cancellous and intracortical envelopes, AFF patients had significantly lower wall thickness (W.Th) and higher osteoclast surface (Oc.S/BS) than non-AFF patients. In addition, AFF patients had significantly higher eroded surface (ES/BS) only in the intracortical envelope. None of the dynamic variables related to bone formation and turnover differed significantly between the groups. In conclusion, in the ilium of BP-treated patients with osteoporosis, AFF patients have lower thickness of superficial bone (lower W.Th) of the cancellous and cortical envelopes than non-AFF patients. AFF and non-AFF patients have a similar bone turnover rate in the ilium. Furthermore, in this population, as in previous work, AFF is more likely to occur in BP-treated patients with longer treatment duration.
Enhanced osteoporotic fracture prediction in postmenopausal women using Bayesian optimization of machine learning models with genetic risk score
Authors: Wu Qing , Dai Jingyuan 
Published: February 2024

Abstract
This study aimed to enhance the fracture risk prediction accuracy in major osteoporotic fractures (MOFs) and hip fractures (HFs) by integrating genetic profiles, machine learning (ML) techniques, and Bayesian optimization. The genetic risk score (GRS), derived from 1,103 risk single nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS), was formulated for 25,772 postmenopausal women from the Women's Health Initiative dataset. We developed four ML models: Support Vector Machine (SVM), Random Forest, XGBoost, and Artificial Neural Network (ANN) for binary fracture outcome and 10-year fracture risk prediction. GRS and FRAX clinical risk factors (CRFs) were used as predictors. Death as a competing risk was accounted for in ML models for time-to-fracture data. ML models were subsequently fine-tuned through Bayesian optimization, which displayed marked superiority over traditional grid search. Evaluation of the models' performance considered an array of metrics such as accuracy, weighted F1 Score, the area under the precision-recall curve (PRAUC), and the area under the receiver operating characteristic curve (AUC) for binary fracture predictions, and the C-index, Brier score, and dynamic mean AUC over a 10-year follow-up period for fracture risk predictions. We found that GRS-integrated XGBoost with Bayesian optimization is the most effective model, with an accuracy of 91.2% (95% CI: 90.4–92.0%) and an AUC of 0.739 (95% CI: 0.731–0.746) in MOF binary predictions. For 10-year fracture risk modeling, the XGBoost model attained a C-index of 0.795 (95% CI: 0.783–0.806) and a mean dynamic AUC of 0.799 (95% CI: 0.788–0.809). Compared to FRAX, the XGBoost model exhibited a categorical net reclassification improvement (NRI) of 22.6% (P = .004). A sensitivity analysis, which included BMD but lacked GRS, reaffirmed these findings. Furthermore, portability tests in diverse non-European groups, including Asians and African Americans, underscored the model's robustness and adaptability. This study accentuates the potential of combining genetic insights and optimized ML in strengthening fracture predictions, heralding new preventive strategies for postmenopausal women.
Familial multiple lipomatosis associated with multiple cherry hemangiomas and moles: a rare case report
Authors: Guntupalli Gopalaswamy , Ramadugu Rithika , Suvvari Tarun K , Ravipati Shivani , Thomas Vimal 
Published: February 2024

Abstract
Lipomas are common benign mesenchymal tumours, whereas lipomatoses are uncommon. Familial multiple lipomatosis (FML) is a rare syndrome characterized by multiple usually painless lipomas which may be associated with other conditions. FML is considered to be genetic, with various patterns of inheritance suggested. In this case report, we described a case of multiple familial lipomatosis that was misdiagnosed as dercum’s disease.
Extreme dislocation of the cervical spine—case report
Authors: Zagorac Slavisa , Vasic Milos , Novakovic Uros , Mladenovic Milos , Tulic Ivan , Teodosic Valerija , Vracevic Dragana 
Published: February 2024

Abstract
We present the case of rare extreme dislocation of subaxial cervical spine, which was challenging regarding type and time of surgery. A 22-year-old patient was injured in a traffic accident, from very beginning with signs of spinal shock. Severe traumatic C6/C7 dislocation with resulting transection of the spinal cord was diagnosed with MDCT imaging. The main dilemmas regarding the surgical treatment of this injury referred to the timing of surgery and the choice of surgical approach. We decided to perform posterior surgery at first stage. Postoperative her condition get worsening and on the 16th postoperative day came to the fatal outcome. Despite all the available protocols, in our case, the decision had to be made on the basis of individual multidisciplinary assessment, bearing in mind the mechanism of the injury and the clinical presentation of the injured patient.
Transverse oscillations of two parallel magnetic tubes with slowly changing density
Authors: Ruderman M S , Petrukhin N S 
Published: February 2024

ABSTRACT
We study kink oscillations of the system of two parallel magnetic tubes in the presence of plasma cooling. We assume that the characteristic cooling time is much larger than the characteristic time of kink oscillations. Using the ratio of two characteristic times as a small parameter, we derive the expression for the adiabatic invariant, which is a quantity that remains constant during the cooling process. Then, we study in detail a particular case where the plasma densities in the two tubes are the same, the plasma temperature outside of the tube does not change, and the plasma temperature inside the tubes decreases exponentially. We found that cooling causes the increase of the oscillation frequencies and amplitudes. These results are the generalization of similar results previously obtained for a single magnetic tube. We compared the efficiency of amplification of kink oscillations caused by cooling in counteracting the damping of oscillations due to resonant absorption in two models of coronal magnetic loops: monolithic and consisting of two parallel filaments.
Detecting non-thermal emission in a solar microflare using nested sampling
Authors: Cooper Kristopher , Hannah Iain G , Glesener Lindsay , Grefenstette Brian W 
Published: February 2024

ABSTRACT
Microflares are energetically smaller versions of solar flares, demonstrating the same processes of plasma heating and particle acceleration. However, it remains unclear down to what energy scales this impulsive energy release continues, which has implications for how the solar atmosphere is heated. The heating and particle acceleration in microflares can be studied through their X-ray emission, finding predominantly thermal emission at lower energies; however, at higher energies it can be difficult to distinguish whether the emission is due to hotter plasma and/or accelerated electrons. We present the first application of nested sampling to solar flare X-ray spectra, an approach that provides a quantitative degree of confidence for one model over another. We analyse Nuclear Spectroscopic Telescope Array X-ray observations of a small active region microflare (A0.02 GOES/XRS class equivalent) that occurred on 2021 November 17, with a new python package for spectral fitting, sunkit-spex, to compute the parameter posterior distributions and the evidence of different models representing the higher energy emission as due to thermal or non-thermal sources. Calculating the Bayes factor, we show that there is significantly stronger evidence for the higher energy microflare emission to be produced by non-thermal emission from flare-accelerated electrons than by an additional hot thermal source. Qualitative confirmation of this non-thermal source is provided by the lack of hotter (10 MK) emission in Solar Dynamic Observatory’s Atmospheric Imaging Assembly’s extreme ultraviolet data. The nested sampling approach used in this paper has provided clear support for non-thermal emission at the level of 3 × 1024 erg s−1 in this tiny microflare.
The ALMaQUEST Survey XIV: do radial molecular gas flows affect the star-forming ability of barred galaxies?
Authors: Hogarth L M , Saintonge A , Davis T A , Ellison S L , Lin L , López-Cobá C , Pan H -A , Thorp M D 
Published: February 2024

ABSTRACT
We investigate whether barred galaxies are statistically more likely to harbour radial molecular gas flows and what effect those flows have on their global properties. Using 46 galaxies from the ALMA-MaNGA QUEnching and STar formation (ALMaQUEST) survey, we identify galaxies hosting optical bars using a combination of the morphological classifications in Galaxy Zoo 2 and HyperLEDA. In order to detect radial molecular gas flows, we employ full 3D kinematic modelling of the ALMaQUEST 12CO(1–0) data cubes. By combining our bar classifications with our radial bar-driven flow detections, we find that galaxies classed as barred are statistically more likely to host large-scale radial gas motions compared to their un-barred and edge-on galaxy counterparts. Moreover, the majority of barred galaxies require multicomponent surface brightness profiles in their best-fitting models, indicative of the presence of resonance systems. We find that galaxies classed as barred with radial bar-driven flows (‘barred + radial flow’ subset) have significantly suppressed global star-formation efficiencies compared to barred galaxies without radial bar-driven flows and galaxies in the other morphological sub-samples. Our ‘barred + radial flow’ subset galaxies also possess consistently centrally concentrated molecular gas distributions, with no indication of depleted gas mass fractions, suggesting that gas exhaustion is not the cause of their suppressed star formation. Furthermore, these objects have higher median gas mass surface densities in their central 1 kpc, implying that central gas enhancements do not fuel central starbursts in these objects. We propose that dynamical effects, such as shear caused by large-scale inflows of gas, act to gravitationally stabilize the inner gas reservoirs.
Accretion and magnetism on young eccentric binaries: DQ Tau and AK Sco
Authors: Pouilly Kim , Hahlin Axel , Kochukhov Oleg , Morin Julien , Kóspál Ágnes 
Published: February 2024

ABSTRACT
The accretion and ejection of mass in pre-main-sequence (PMS) stars are key processes in stellar evolution as they shape the stellar angular momentum transport necessary for the stars’ stability. Magnetospheric accretion on to classical T Tauri stars and low-mass PMS stars has been widely studied in the single-star case. This process cannot be directly transferred to PMS binary systems, as tidal and gravitation effects, and/or accretion from a circumbinary disc (with variable separation of the components in the case of eccentric orbits) are in place. This work examines the accretion process of two PMS eccentric binaries, DQ Tau and AK Sco, using high-resolution spectropolarimetric time series. We investigate how magnetospheric accretion can be applied to these systems by studying the accretion-related emission lines and the magnetic field of each system. We discover that both systems are showing signs of magnetospheric accretion, despite their slightly different configurations, and the weak magnetic field of AK Sco. Furthermore, the magnetic topology of DQ Tau A shows a change relative to the previous orbital cycle studied: previously dominated by the poloidal component, it is now dominated by the toroidal component. We also report an increase of the component’s accretion and the absence of an accretion burst at the apastron, suggesting that the component’s magnetic variation might be the cause of the inter-cycle variations of the system’s accretion. We conclude on the presence of magnetospheric accretion for both systems, together with gravitational effects, especially for AK Sco, composed of more massive components.
Emergence of the temperature–density relation in the low-density intergalactic medium
Authors: Wells Alexandra , Robinson David , Avestruz Camille , Gnedin Nickolay Y 
Published: February 2024

ABSTRACT
We examine the evolution of the phase diagram of the low-density intergalactic medium during the Epoch of Reionization in simulation boxes with varying reionization histories from the Cosmic Reionization on Computers project. The probability density function (PDF) of gas temperature at fixed density exhibits two clear modes: a warm and a cold temperature mode, corresponding to the gas inside and outside of ionized bubbles. We find that the transition between the two modes is ‘universal’ in the sense that its timing is accurately parametrized by the value of the volume-weighted neutral fraction for any reionization history. This ‘universality’ is more complex than just a reflection of the fact that ionized gas is warm and neutral gas is cold: it holds for the transition at a fixed value of gas density, and gas at different densities transitions from the cold to the warm mode at different values of the neutral fraction, reflecting a non-trivial relationship between the ionization history and the evolving gas density PDF. Furthermore, the ‘emergence’ of the tight temperature–density relation in the warm mode is also approximately ‘universally’ controlled by the volume-weighted neutral fraction for any reionization history. In particular, the ‘emergence’ of the temperature–density relation (as quantified by the rapid decrease in its width) occurs when the neutral fraction is 10−4 ≲ XH i ≲ 10−3 for any reionization history. Our results indicate that the neutral fraction is a primary quantity controlling the various properties of the temperature–density relation, regardless of reionization history.
Balancing Faith and Equality: Examining the Adequacy of the Doctrine of Essential Religious Practices from Gender Perspectives in India
Authors: Sonkar Sumit 
Published: February 2024

ABSTRACT
The Supreme Court of India formulated the doctrine of essential religious practices as a legal framework to protect the right to religious practice while enabling the State to implement social reforms, as provided under Article 25 of the Constitution. This article contends that although this doctrine was created to reconcile competing legal frameworks, its inconsistent and incoherent application cannot meaningfully resolve religious disputes – leaving many normative gaps. Consequently, this doctrine needs to be re-evaluated to balance religious freedom with other fundamental rights. Thus, this article assesses the doctrine of essential religious practices, its nature, scope, concerns, and criticism from gender equality perspectives.
The Efficacy of Immune Checkpoint Inhibitors in Microsatellite Stable Colorectal Cancer: A Systematic Review
Authors: Guven Deniz Can , Kavgaci Gozde , Erul Enes , Syed Masood Pasha , Magge Tara , Saeed Anwaar , Yalcin Suayib , Sahin Ibrahim Halil 
Published: February 2024

Abstract
The use of immune checkpoint inhibitors (ICIs) has revolutionized cancer care, particularly in immune-inflamed tumors and tumors with a high mutational burden, like microsatellite instable colorectal cancer (CRC). However, their effectiveness in microsatellite stable (MSS) CRC is limited. This systematic review aims to evaluate the efficacy of ICIs in MSS CRC and explore promising combination strategies. A comprehensive search from the Web of Science, Medline, and Embase databases, for studies published until 14 November 2022, identified 53 clinical trials included in the review. ICI monotherapy or ICI-ICI combinations demonstrated limited clinical activity for patients with MSS CRC, with overall response rates below (ORR) 10% in most studies. The ICI and tyrosine kinase inhibitor (TKI) garnered ORRs ranging from 10% to 40% and indicated a higher benefit for patients, particularly those without active liver metastases. The combination of ICIs with anti-VEGF agents showed modest ORRs, especially in the earlier treatment lines and in combination with chemotherapy. While these combinations could lead to modest improvements, well-defined biomarkers for long-term benefit are yet to be delineated. Combinations involving BRAF inhibitors with ICIs were studied, showing promising responses with combination approaches in molecularly defined subgroups. In conclusion, while ICI monotherapy has limited efficacy in MSS CRC, combination strategies hold promise to enhance survival outcomes. Further research is necessary to identify optimal combination approaches, predictive biomarkers for treatment response, as well as enrollment according to tumor molecular characteristics.
Perceived experts are prevalent and influential within an antivaccine community on Twitter
Authors: Harris Mallory J , Murtfeldt Ryan , Wang Shufan , Mordecai Erin A , West Jevin D 
Published: February 2024

Abstract
Perceived experts (i.e. medical professionals and biomedical scientists) are trusted sources of medical information who are especially effective at encouraging vaccine uptake. The role of perceived experts acting as potential antivaccine influencers has not been characterized systematically. We describe the prevalence and importance of antivaccine perceived experts by constructing a coengagement network of 7,720 accounts based on a Twitter data set containing over 4.2 million posts from April 2021. The coengagement network primarily broke into two large communities that differed in their stance toward COVID-19 vaccines, and misinformation was predominantly shared by the antivaccine community. Perceived experts had a sizable presence across the coengagement network, including within the antivaccine community where they were 9.8% of individual, English-language users. Perceived experts within the antivaccine community shared low-quality (misinformation) sources at similar rates and academic sources at higher rates compared to perceived nonexperts in that community. Perceived experts occupied important network positions as central antivaccine users and bridges between the antivaccine and provaccine communities. Using propensity score matching, we found that perceived expertise brought an influence boost, as perceived experts were significantly more likely to receive likes and retweets in both the antivaccine and provaccine communities. There was no significant difference in the magnitude of the influence boost for perceived experts between the two communities. Social media platforms, scientific communications, and biomedical organizations may focus on more systemic interventions to reduce the impact of perceived experts in spreading antivaccine misinformation.
Eigenphase distributions of unimodular circular ensembles
Authors: Nishigaki Shinsuke 
Published: February 2024

Abstract
Motivated by the study of Polyakov lines in gauge theories, Hanada and Watanabe recently presented a conjectured formula for the distribution of eigenphases of Haar-distributed random SU(N) matrices (β = 2), supported by explicit examples at small N and by numerical samplings at larger N. In this letter, I spell out a concise proof of their formula, and present its orthogonal and symplectic counterparts, i.e. the eigenphase distributions of Haar-random unimodular symmetric (β = 1) and selfdual (β = 4) unitary matrices parametrizing SU(N)/SO(N) and SU(2N)/Sp(2N), respectively.
A real-world pilot study assessing treatment satisfaction with avanafil in patients with erectile dysfunction
Authors: Tsai Ping-Ju , Hung Shih-Ya , Lee Tsung-Hsi , Jiann Bang-Ping 
Published: February 2024

Abstract

Background
Avanafil is a second-generation phosphodiesterase type 5 (PDE5) inhibitor, and offers a rapid onset of action (15 minutes). Its real-world data, including treatment satisfaction, are still lacking.

Aim
The study sought to investigate the treatment outcomes of avanafil and the factors impacting treatment satisfaction in a real-world setting.

Methods
Between November 2021 and February 2023, erectile dysfunction (ED) patients prescribed avanafil were consecutively enrolled in this phase 4, open-label, cross-sectional, observational study. At each follow-up visit (4-week intervals), participants completed a questionnaire for assessing the use and treatment-emergent adverse events of avanafil, ED severity, and treatment satisfaction.

Outcomes
The outcome measures included the Sexual Health Inventory for Men (SHIM), and Erectile Dysfunction Inventory of Treatment Satisfaction.

Results
Among 234 patients enrolled, 112 (47.9%) patients had follow-up visits and answered the questionnaire. Treatment with avanafil significantly improved the mean SHIM total score from 10.2 ± 5.6 at baseline to 17.5 ± 6.2 (P &lt; .001). Of the patients treated with avanafil, 71.4% (n = 80 of 112) reported a &gt;4-point improvement in the SHIM total score, and 33.1% (n = 37 of 112) reported normal erectile function. The proportion of patients satisfied with avanafil treatment (defined as Erectile Dysfunction Inventory of Treatment Satisfaction index score ≥60) was 87.5%. Several physical factors (younger age, lower waist circumference, and lower level of low-density lipoprotein), and sexual function factors (shorter duration of ED, higher SHIM total score at baseline, PDE5 inhibitor treatment naive, and acquired premature ejaculation) tended to contribute to satisfaction with avanafil treatment. Treatment-emergent adverse events occurred in 41.1% of patients, and all were mild in severity.

Clinical Implications
This study identifies the factors associated with treatment satisfaction of avanafil, which may ultimately lead to better treatment outcomes.

Strengths and Limitations
This is the first study to provide real-world evidence of avanafil for ED treatment, and validated questionnaires were used to assess erectile function and treatment satisfaction. However, the limitations of this study include single-center observational study design, small sample size, and short-term follow-up.

Conclusion
Avanafil is an effective treatment for ED, and satisfaction rate is high in an outpatient setting. The awareness of identified factors related to patient satisfaction may improve treatment outcomes.