bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding strategies that foster nurses to act as clinical leaders in hospitals: A realist review
Authors: Duprez Veerle , Dhont Laure , van der Cingel Margreet , Hafsteinsdóttir Thóra B. , Malfait Simon 
Published: October 2023

AbstractAimTo identify strategies that develop clinical nursing leadership competencies among staff nurses, and to explain the contextual elements and mechanisms that underpin the development of clinical nursing leadership competencies.DesignRealist review according to the Realist and Meta‐narrative Evidence Syntheses—Evolving Standards (RAMESES).Data SourcesPubMed, Embase, CINAHL, Web of Science, Wiley Online Library, PsycInfo and ProQuest were searched from January 2000 until October 2022.Review MethodsThree iterative phases: (1) development of initial programme theory, (2) structured searches for relevant published and grey literature and (3) data synthesis and interpretation by researchers and theory triangulation, and discussions within the research group.ResultsMultiple context–mechanism–outcome configurations were extracted from 10 reports that explain how, under what circumstances and why strategies can facilitate (or discourage) staff nurses to act as clinical leaders. Reports were both quantitative and qualitative in design, originating from English‐speaking countries only.ConclusionsA logic model was developed and suggests four contexts and five mechanisms underlying the development of clinical nursing leadership. Growth in clinical nursing leadership was mainly experienced through experiential learning, which was enhanced by a supportive relationship with a coach or mentor, the use of reflective practices and modelling from other leaders. Furthermore, a supportive work environment triggers ownership, confidence and motivation, and thereby growth in clinical nursing leadership competencies.ImpactFostering competencies for clinical leadership among staff nurses requires multifaceted strategies. Strategies are successful if, and only if, they combine learning by doing, by knowing and by observing, and establish a responsive work environment. Hospital policy should ensure that staff nurses have access to reciprocal relationships with role models or a coach. In order to grow as clinical nurse leader, ownership and self‐reflection on own leadership behaviour need to be facilitated.No Patient or Public ContributionProspero ID CRD42021292290.
miR‐6076 targets BCL6 in SH‐SY5Y cells to regulate amyloid‐β‐induced neuronal damage
Authors: Lin Yujian , Zhang Lei , Gao Mengyue , Tang Zixin , Cheng Xiang , Li Haoming , Qin Jianbing , Tian Meiling , Jin Guohua , Zhang Xinhua , Li Wen 
Published: October 2023

AbstractAmyloid‐β1‐42 (Aβ1‐42) is strongly associated with Alzheimer's disease (AD). The aim of this study is to elucidate whether and how miR‐6076 participates in the modulation of amyloid‐β (Aβ)‐induced neuronal damage. To construct the neuronal damage model, SH‐SY5Y cells were treated with Aβ1‐42. By qRT‐PCR, we found that miR‐6076 is significantly upregulated in Aβ1‐42‐treated SH‐SY5Y cells. After miR‐6076 inhibition, p‐Tau and apoptosis levels were downregulated, and cell viability was increased. Through online bioinformatics analysis, we found that B‐cell lymphoma 6 (BCL6) was a directly target of miR‐6076 via dual‐luciferase reporter assay. BCL6 overexpression mediated the decrease in elevated p‐Tau levels and increased viability in SH‐SY5Y cells following Aβ1‐42 treatment. Our results suggest that down‐regulation of miR‐6076 could attenuate Aβ1‐42‐induced neuronal damage by targeting BCL6, which provided a possible target to pursue for prevention and treatment of Aβ‐induced neuronal damage in AD.
Association between periodontal diseases and chronic obstructive pulmonary disease: Evidence from sequential cross‐sectional and prospective cohort studies based on UK Biobank
Authors: Wang Dongyun , Dai Liang , Cui Zhengqian , Xing Weili , Huang Xiaoyan , Yang Hongyu , Shan Ying 
Published: October 2023

AbstractAimTo investigate the association between periodontal diseases, airflow limitation and incident chronic obstructive pulmonary disease (COPD) in a large‐scale prospective UK Biobank cohort.Materials and MethodsOur approach comprised a cross‐sectional study and a prospective cohort. Periodontal diseases were determined based on the participants' self‐reported dental symptoms, including painful gums, bleeding gums and loose teeth. Logistic regression and Cox proportional hazards models were used to evaluate the association of periodontal diseases with airflow limitation and incident COPD in the cross‐sectional study and the prospective cohort, respectively.ResultsThe cross‐sectional study involved 495,610 participants. Multivariable analysis found that periodontal diseases were significantly associated with airflow limitation (odds ratio = 1.036, 95% confidence interval [CI]: 1.015–1.059). The cohort study included 379,266 participants with a median follow‐up period of 12.68 years. An elevated risk of incident COPD was associated with the presence of periodontal diseases (hazard ratio: 1.248, 95% CI: 1.174–1.326). The effect was consistent among subgroups, including baseline age (≤65 or >65 years), sex, smoking status and diabetes mellitus.ConclusionsPeriodontal diseases are associated with airflow limitation and elevated COPD incidence. Maintaining good periodontal health in patients with chronic bronchitis and emphysema may help prevent the onset of COPD.
SARS‐CoV‐2 infection correlates with male benign prostatic hyperplasia deterioration
Authors: Liu Alex Qinyang , Chiu Peter Ka‐Fung , Yee Samuel Chi‐Hang , Ng Chi‐Fai , Teoh Jeremy Yuen‐Chun 
Published: October 2023

AbstractIntroductionSevere acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) affects extra‐respiratory systems, with small‐scale studies showing worsened male lower urinary tract symptoms (LUTS) after coronavirus disease 2019 (COVID‐19). This study explores the correlation between SARS‐CoV‐2 infection and male benign prostatic hyperplasia (BPH) complications using large‐scale real world data.Materials and methodsAll male patients attending the public healthcare system in Hong Kong receiving alpha‐blocker monotherapy for LUTS from 2021 to 2022 were included in this study. Patients with and without positive polymerase chain reaction (PCR) test for SARS‐CoV‐2 are selected as the exposure group and control group, respectively. Baseline characteristics are retrieved, with propensity score matching performed to ensure balance of covariates between the two groups. BPH complications were then compared and subgroup analyses were performed.ResultsAfter propensity score matching, 17,986 patients were included for analysis, among which half had PCR‐confirmed SARS‐CoV‐2 infection (n = 8993). When compared to controls, the SARS‐CoV‐2 group demonstrated statistically significant higher incidence of retention of urine (4.55% vs. 0.86%,p < 0.001), haematuria (1.36% vs. 0.41%,p < 0.001), clinical urinary tract infection (UTI) (4.31% vs. 1.49%,p < 0.001), culture‐proven bacteriuria (9.02% vs. 1.97%,p < 0.001) and addition of 5ARI (0.50% vs. 0.02%,p < 0.001). Subgroup analysis demonstrated similar differences across different age groups. There are no statistically significance differences in incidence of retention, haematuria, or addition of 5ARI across different COVID‐19 severities.ConclusionsSARS‐CoV‐2 infection is associated with increased incidence of urinary retention, haematuria, UTI and the addition of combination therapy in the short term, regardless of COVID‐19 severity. This is the largest study demonstrating the detrimental urological effects of SARS‐CoV‐2 infection.
Oral melanoacanthoma: Clinicopathological and immunohistochemical features of a case series and a scoping review
Authors: Tavares Thalita Soares , da Costa Adriana Aparecida Silva , da Mata Camargos Felipe , Gomez Ricardo Santiago , Nonaka Cassiano Francisco Weege , Alves Pollianna Muniz , Mendonça Elismauro Francisco , Sousa‐Neto Sebastião Silvério , Vasconcelos Ana Carolina Uchoa , Tarquínio Sandra Beatriz Chaves , Caldeira Patrícia Carlos 
Published: October 2023

AbstractBackgroundThis study presents a case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics.MethodsNine cases of oral melanoacanthoma were included in the case series. Clinical data were collected from biopsy charts. Hematoxylin–eosin and immunohistochemistry for TRP2, CD3, and CD20 were done. For the scoping review, MEDLINE/PubMed, Web of Science, EMBASE, and Scopus were searched.ResultsCase series: The mean age was 46.8 years (female‐to‐male ratio 2:1). Lesion's mean size was 11.0 mm (±9.3). Lesions were mainly macular (77.8%) with brown or black coloration (88.9%) and often affected multiple sites (44.4%). The evolution time ranged from 15 days to 96 months. Lesions commonly showed epithelial acanthosis (66.7%), spongiosis (55.6%), exocytosis (77.8%), melanin incontinence (88.9%), and inflammatory infiltrate in the lamina propria (77.8%), from which all showed lymphocytes. TRP2‐positive melanocytes were identified in the basal and spinous layer of all cases, and in the superficial layer of three cases. CD3‐positive cells predominate over the CD20‐positive. Scoping review: 85 cases of oral melanoacanthoma were retrieved from 55 studies. Patients were primarily female (female‐to‐male ratio 2.2:1), black‐skinned (64.1%), with a mean age of 36.13 (± 17.24). Lesions were flat (81.9%), often brown (62.4%). Buccal mucosa was the preferred site (32.9%), followed by multiple sites (28.2%).ConclusionOral melanoacanthoma mainly affects women across a wide age range, with lesions commonly appearing as brown/black macules, particularly on the buccal mucosa. TRP2‐positive melanocytes and T‐lymphocytes were consistently found and could participate in oral melanoacanthoma pathogenesis.
Large T‐cell extradural lymphoma with concurrent marked cerebrospinal fluid eosinophilia in a dog
Authors: Massie Anna M. , Skorupski Katherine , Vernau William , McLarty Ehren , Brady Rachel V. , Vernau Karen M. 
Published: October 2023

AbstractA 3‐year‐old male pit bull terrier was presented for a 4‐day history of progressive tetraparesis and cervical pain. Magnetic resonance imaging confirmed an extradural mass within the left lateral vertebral canal extending from caudal C5 to mid‐T2. Lumbar cerebrospinal fluid (CSF) demonstrated marked (90%) eosinophilic inflammation. A C6‐7 dorsal laminectomy and C7‐T2 left hemilaminectomy were done, with gross disease remaining. Histopathology revealed a large T cell lymphoma with marked eosinophilic infiltration. The dog underwent CHOP‐based chemotherapy with resolution of clinical signs, with a similar course of therapy performed at recurrence 37 months after initial presentation. The dog was euthanized 39 months after presentation for multiorgan failure secondary to neutropenic sepsis and aspiration pneumonia. This represents a positive long‐term response to multimodal treatment of extradural T‐cell lymphoma within the vertebral canal associated with a marked CSF eosinophilia.
Light noble gases in 11 achondrites: Cosmic ray exposure ages, gas retention ages, and preatmospheric sizes
Authors: Smith Thomas , He Huaiyu , Li Shijie , Su Fei 
Published: October 2023

AbstractWe report light noble gas (He, Ne, and Ar) concentrations and isotopic ratios in 11 achondrites, Tafassasset (unclassified primitive achondrite), Northwest Africa (NWA) 12934 (angrite), NWA 12573 (brachinite), Jiddat al Harasis (JaH) 809 (ureilite), NWA 11562 (ungrouped achondrite), four lodranites (NWA 11901, NWA 7474, NWA 6685, and NWA 6484), NWA 2871 (acapulcoite), and Sahara 02029 (winonaite), most of which have not been previously studied for noble gases. We discuss their noble gas isotopic composition, determine their cosmogenic nuclide content, and systematically calculate their cosmic ray exposure (CRE) and gas retention ages. In addition, we estimate their preatmospheric radii and preatmospheric masses based on the shielding parameter (22Ne/21Ne)cos. None of the studied meteorites shows evidence of contribution from solar cosmic rays (SCRs). JaH 809 and NWA 12934 show evidence of 3He diffusive losses of >90% and 40%, respectively. The winonaite Sahara 02029 has lost most of its noble gases, either during or before analysis. The average CRE age of Tafassasset of ~49 Ma is lower than that reported by Patzer et al. (2003), but is consistent with it within the uncertainties; this confirms that Tafassasset and CR chondrites are not source paired, CR chondrites having CRE ages from 1 to 25 Ma (Herzog & Caffee, 2014). The ureilite JaH 809 has a CRE age of ~5.4 Ma, which falls into the typical range of exposure ages for ureilites; the angrite NWA 12934 has a CRE age of ~49 Ma, which is within the main range of exposure ages reported for angrites (0.2–56 Ma). We calculate a CRE age of ~2.4 Ma for the brachinite NWA 12573, which falls into a possible “cluster” in the brachinite CRE age histogram around ~3 Ma. Three lodranites (NWA 11901, NWA 7474, and NWA 6685) have CRE ages higher than the average CRE ages of lodranites measured so far, NWA 11901 and NWA 6685 having CRE ages far higher than the CRE age already reported by Li et al. (2019) on NWA 8118. The measured 40K‐40Ar gas retention ages fit well into established systematics. The gas retention age of Tafassasset is consistent, within respective uncertainties, with that previously calculated by Patzer et al. (2003). Our study indicates that Tafassasset originates from a meteoroid with a preatmospheric radius of ~20 cm, however discordant with the radius of ~85 cm inferred in a previous study (Patzer et al., 2003).
The “Meteorite meter”: A handheld instrument for the combined measurement of magnetic susceptibility and electrical conductivity, with application to meteorite identification and classification
Authors: Uehara Minoru , Gattacceca Jérôme 
Published: October 2023

AbstractWe developed a simple, handheld, and user‐friendly magnetic susceptibility meter specialized for the identification of meteorites. The measurement is based on an LC resonance circuit. When provided with a rough estimate of the sample mass, the instrument displays directly the mass‐normalized magnetic susceptibility expressed in logχm (with χm in 10−9 m3 kg−1), a parameter that is widely used in the classification of meteorites. Moreover, the measurement of the impedance of the LC resonator provides a proxy of the electrical conductivity (C‐index) that can be helpful to distinguish metal‐bearing samples from magnetite‐bearing samples. This C‐index offers an additional diagnostic for the identification of meteorites. Our tests demonstrate that the precision and the accuracy of this instrument called “Meteorite meter” (MetMet) are sufficient to allow distinguishing most meteorites from most terrestrial rocks, for a minimum recommended sample mass of 5 g. The distinction of some meteorite groups is also possible, in particular the separation of the three ordinary chondrite groups. Meteorite hunters, collectors, and curators and non‐specialists, including children, can use this instrument as a guidance in the identification and classification of meteorites. This kind of instrument has an immense advantage over the widely used testing of meteorites with magnets, as it does not affect the paleomagnetic records of meteorites that are highly valuable for scientists.
Are infants conscious?
Authors: Passos‐Ferreira Claudia 
Published: October 2023

AbstractI argue that newborn infants are conscious. I propose a methodology for investigating infant consciousness and I present two approaches for determining whether newborns are conscious. First, I consider behavioral and neurobiological markers of consciousness.Second, I investigate the major theories of consciousness, including both philosophical and scientific theories, and I discuss what they predict about infant consciousness.
Risk coupling analysis under accident scenario evolution: A methodological construct and application
Authors: Yao Jianting , Zhang Boling , Wang Dongdong , Lei Dachen , Tong Ruipeng 
Published: October 2023

AbstractDynamic processes in various fields exhibit risk coupling phenomena, but existing risk analysis studies tend to ignore the risk coupling effects of dynamic scenarios. Considering the principles of digitization, objective quantification, and the full process that should be adopted in the risk coupling analysis, an integrated risk coupling analysis framework is proposed. Specifically, the weighted Eclat algorithm is used to mine the risk association rules, then the key risk factors are extracted by social network analysis, and the stochastic Petri net is used to complete the construction, simulation, and evolution of accident scenarios. This universal framework can analyze the risk phenomena of accident scenario evolution in a process‐oriented manner and decouple risks based on key risk factors and disconnect the chain of the accident scenario evolution process. Finally, the proposed framework is applied to the coupled analysis of fire risk in Chinese urban communities to verify its feasibility and scientific validity.
Gender essentialism predicts prejudice against gender nonconformity in two cultural contexts
Authors: Fine Rachel D. , Olson Kristina R. , Gülgöz Selin , Horton Rachel , Gelman Susan A. 
Published: October 2023

AbstractGender‐nonconforming children face a substantial amount of prejudice, making it important to investigate potential contributing factors. In a correlational study of 253 U.S. Midwestern and Pacific Northwestern 6‐ to 10‐year‐old gender‐conforming children (Age M = 7.95, SD = 1.43; 54% girl, 46% boy; 77% White), we examined how gender essentialism (beliefs that gender is biological, discrete, informative, and immutable) and gender identity essentialism (beliefs that gender identity is immutable) relate to prejudice against gender‐nonconforming children. We also examined whether these associations varied by the child's cultural context (rural, non‐diverse, conservative vs. urban, more diverse, liberal). We found a positive correlation between gender essentialism and prejudice, in both cultural contexts. Additionally, children from the more rural context endorsed more essentialism and expressed more prejudice than did their counterparts from the more urban context. However, we found no differences in children's gender identity essentialism by cultural context and no association with prejudice.
Introduction to INFER special issue on “new aspects of economic and financial integration”
Authors: Afonso António , Badarau Cristina , Turcu Camélia 
Published: October 2023

AbstractThis Special Issue (SI) gathers 13 papers presented at the 23rd INFER Annual Conference which took place in Lisbon, 8–10 September 2021, at ISEG – Lisbon School of Economics and Management. The conference was organised by INFER (International Network for Economic Research), UECE (Research Unit on Complexity and Economics), and REM (Research in Economics and Mathematics). The papers of the SI focus on key topics in international macroeconomics, revisit the fiscal policy conduct within a globalised world, investigate how uncertainty and risk affect macroeconomic policies, and analyse the links between labor market outcomes, automation, and economic integration.
Stroke prevention strategies in Africa: a scoping review protocol
Authors: Umeonwuka Chuka Ifeanyi , Obiora Oluchukwu Loveth , Nstiea Veronica 
Published: October 2023

Objective:
The objective of this scoping review is to map the existing strategies on methods and interventions for primary and secondary stroke prevention in Africa.

Introduction:
Stroke is among the leading causes of disability globally. African nations have higher stroke mortality and case fatality rates than the industrialized world, leading to significant social and financial costs, which necessitates efficient preventative methods. Despite the high prevalence of stroke in Africa, the scope of stroke-prevention strategies in Africa is unknown. Consequently, mapping diverse approaches to preventing stroke in Africa could provide direction for future research into stroke prevention in Africa.

Inclusion criteria:
This review will incorporate studies that report methods or strategies used for stroke prevention in Africa. All primary and gray literature will be considered for inclusion. No language or date restrictions will be applied.

Methods:
The JBI methodological framework for scoping reviews will be adopted for this scoping review. A 3-step search strategy consisting of an initial limited search, a full search, and a screening of the reference lists of all included articles will be undertaken. Databases such as CINAHL, Scopus, PubMed, PEDRo, DORIS, Global Health, Web of Science, and Open Access Thesis and Dissertations will be searched. All search results will be screened, and relevant data extracted by 2 independent reviewers. The findings will be presented in the final scoping review and illustrated in a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram.

Review registration:
Figshare https://doi.org/10.6084/m9.figshare.21679904.v1
From agenda to action: JBI Evidence Synthesis and the United Nations Sustainable Development Goals
Authors: Jordan Zoe , Pilla Bianca 
Published: October 2023

Objective:
This pilot study sought to map the alignment of publications in JBI Evidence Synthesis to the United Nations Sustainable Development Goal (SDG) 3 (global health and well-being) and to understand JBI authors’ awareness of and engagement with the goals. This will contribute to a larger-scale analysis to assist the JBI Collaboration in engaging with and working toward achieving the SDGs.

Introduction:
In 2015, the United Nations agreed on 17 SDGs as the central framework for sustainable development worldwide. However, in the wake of the global pandemic, the 2030 SDG agenda is in jeopardy due to multiple cascading and intersecting crises. The Global Commission on Evidence has urged the evidence community to consider how it might more meaningfully contribute to the evidence architecture. As we pass the midway point to the SDG 2030 target date, it is timely to reflect on the contribution of those in the evidence synthesis community to achieving these important global objectives.

Methods:
A 2-phase study was conducted utilizing desktop audit methods. SDG 3 targets were mapped across systematic and scoping reviews published in JBI Evidence Synthesis using established key terms, followed by a brief author survey and thematic analysis.

Results:
The results of this pilot study indicate that 28.5% of syntheses published in JBI Evidence Synthesis address 11 of the 13 targets of SDG 3. SDGs are not currently a priority consideration for most JBI Evidence Synthesis authors, but there is a desire to learn more and integrate the goals into their prioritization processes.

Conclusions:
While this was only a small pilot study, it is indicative of a need to reset and recommit to mutual global agendas to transform the evidence ecosystem, and to maximize the limited resources available in order to truly have a global impact on health outcomes.