bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of low-level laser therapy and functional exercises in the treatment of chronic ankle sprain: A randomized controlled trial
Authors: Chen Yuan-zheng , Fan Yi-cai , Lin Tian-qiao , Zhou Quan 
Published: December 2023

Abstract

Objective:The purpose of this study is to investigate whether low-level laser therapy (LLLT) combined with functional exercise could be more effective than functional exercise alone in treating chronic ankle sprain. At the same time, to observe the dose-response relationship of LLLT in treating chronic ankle sprains.Methods:Thirty-three patients with chronic ankle sprains were randomly divided into three groups: exercise alone, low-dose laser plus exercise, and high-dose laser plus exercise, with eleven patients in each group. Two “laser groups” received laser irradiation at an intensity of 398 mW/cm2and 796 mW/cm2(doses of 119 J/cm2and 239 J/cm2), respectively, which were applied to two acupoints of Ki 3 (Taixi) and Bl 60 (Kunlun), and two pain points of the ankle. The functional exercise program consisted of ankle resistance exercises, resistance kinematic chain exercises, heel raise exercises, and BOSU ball exercises. All patients received five treatments per week for four weeks. At the end of this treatment and at baseline, observing the changes in ankle pain, range of motion (ROM), muscle strength, and balance postural control, and evaluating the curative effects.Results:After the 4-week intervention, all of the groups showed significant improvement in outcomes (P<0.05). High-dose laser irradiation combined with functional exercise resulted in more significant improvements in the primary outcomes than the other two regimens (P<0.05). However, there were no significant differences (P>0.05) between low-dose laser irradiation combined with functional exercise and functional exercise alone.Conclusion:1) Systematic functional exercise can significantly reduces the pain of patients with chronic ankle sprains, meanwhile improves the ROM, muscle strength, and balance control of the ankle joint. 2) LLLT increases the efficacy of functional exercise in the treatment of chronic ankle sprains. 3) The therapeutic effect of LLLT on chronic ankle sprains is related to the irradiation intensity, and the effects of 796mW/cm2irradiation is better than 398mW/cm2irradiation.
Characterization of type 2 diabetes-related immune response heterogeneity to COVID-19 vaccines via single-cell landscape analyses
Authors: Wang Weiqi , He Wenwen , Wang Shen , Liang Bo , Feng Na , Zhao Yongku , Wang Tiecheng , Zhang Xiaotuan , Yuan Shiqi , Wang Jian , Deng Shanshan , Guo Jingsong , Yang Songtao , Wong Gary , Liu Bin , Yan Feihu , Xia Xianzhu 
Published: December 2023

Abstract
Vaccines provide the most ideal protection against COVID-19, but variants of concern are highly transmissible and less sensitive to vaccine-elicited antibodies. It is unknown whether patients with type 2 diabetes (T2D) can develop vaccine-elicited immune responses equal to those in healthy individuals. Impaired neutralizing antibodies and spike specific antibodies against SARS-CoV-2 have been identified in T2D patients vaccinated with inactivated vaccine. We therefore investigated changes in the peripheral immune systems of vaccinated T2D patients using single-cell RNA-sequencing. The immune cell phenotypes comprised antigen-presenting (APC), T, and plasma cell reconfigurations. Humoral immune damage to plasma cells exhibited impaired protein synthesis, processing, and transport. APCs were characterized by inflammation following human leukocyte antigen downregulation, neutrophil recruitment, and type I interferon pathway defects. Oxidative stress yielded abnormal hyper-inflammation comprising hyper-cytotoxic CD4+ and CD8+ T cells. There was also a decreased subset of SARS-CoV-2-specific B and T cell receptors. These results provide mechanistic insights into the COVID-19 vaccine-elicited immune responses of T2D patients.
Laser-assisted See-through Technology for Locating Sound Sources Inside a Structure
Authors: Wu Sean F. , Lu Yazhong , Ernest Cameron , Zhao Yang , Chen Lingguang 
Published: December 2023

Abstract
A laser-assisted see-through technology is developed to locate sound sources inside a structure and to analyze the interior sound field. Six lasers were utilized to measure the normal velocities on the exterior surface simultaneously, which were used to locate sound sources inside a structure through a passive sonic detection and ranging algorithm. Next, the Helmholtz equation least squares method was applied to reconstruct the interior sound field, and computer tomography utilized to scan space and time simultaneously to observe the changes of the interior sound field over time. If signals are time invariant, we can do all these with two lasers, one being fixed and another measuring the normal surface velocities and establish the transfer functions with respect to the stationary laser sequentially. This laser-assisted see-through technology was validated experimentally and employed to view the aerodynamically-induced sound field generated by a blower inside a projector. The reason that we can break the barrier in sound source localization is that measurements are taken on an impenetrable surface, whose normal velocity is continuous across the thickness of the surface. This discovery is groundbreaking. It embodies a significant advancement in sound source localization, and opens the door to a class of applications presently unattainable.
Population Pharmacokinetics of Pantoprazole in Patients on Dual Antiplatelet Therapy following Acute Coronary Syndrome
Authors: Nikolic Valentina N. , Stokanovic Dragana , Jankovic Slobodan M. , Konstantinovic Sandra S. , Zvezdanovic Jelena B. , Lilic Jelena , Jevtovic-Stoimenov Tatjana , Stefanovic Nikola , Apostolovic Svetlana R. , Milovanovic Jasmina R. 
Published: December 2023

Abstract
Purpose
Pantoprazole, a widely prescribed proton pump inhibitor, is still not fully characterized in terms of its pharmacokinetic (PK) properties. In this study, we employed nonlinear mixed-effects modeling to investigate factors influencing the variability in pantoprazole PK in patients with acute coronary syndrome undergoing dual antiplatelet therapy.
Methods
Blood samples were collected from 93 adult males and females receiving oral pantoprazole. Through a stepwise regression procedure various demographic and clinical covariates were tested in relation to pantoprazole concentration and elimination. These results were further substantiated by the reduction of point dispersion in goodness-of-fit plots, depicting the individual predicted versus measured concentrations, and through bootstrapping analysis.
Results
Pantoprazole clearance is notably influenced by C-reactive protein (CRP) levels and concurrent use of statins.
Conclusion
This discovery holds significant implications for tailoring pantoprazole treatment on an individual basis, providing valuable insights for optimizing therapeutic strategies in the management of patients with acute coronary syndrome, thereby maximizing therapeutic benefits.
Ridge preservation using octacalcium phosphate collagen to induce new bone containing a vascular network of mainly Type H vessels
Authors: Kaida Naoki , Matsunaga Satoru , Tachiki Chie , Sugahara Keisuke , Kasahara Norio , Ohtsu Yuto , Abe Shinichi , Yamamoto Hitoshi , Katakura Akira , Nishii Yasushi 
Published: December 2023

Abstract
Many studies have shown that it is important to use bone grafts that are easy to mold, bioabsorbable, and stable over time. We focused on Type H blood vessels, which were discovered by Kusumbe et al. in 2014 to be responsible for the interaction between angiogenesis and osteogenesis. The aim of this study was to assess the effect of octacalcium phosphate collagen (OCP/Col), on the healing processes of the extraction socket and the alveolar bone surrounding the extraction socket. Ridge preservation of rat lower first molars was conducted using OCP/Col, and a series of experiments involving micro-CT scanning, observations of new bone, bone morphometry measurements, histological and immunohistochemical analyses, and second harmonic generation imaging were conducted to analyze bone mass, bone quality, angiogenesis, and mechanical properties. The results demonstrate that the calcification level was not very high when using OCP/Col for RP. Moreover, the newly formed bone is rich in vascular components and collagen fibers that are essential for bone tissue remodeling. These characteristics of OCP/Col in RP could contribute significantly to the construction of a rich vascular network around dental implants immediately after implant placement and the subsequent acquisition of osseointegration and reconstruction of the surrounding tissue.
Establishment of a novel weight reduction index after laparoscopic sleeve gastrectomy based on abdominal fat area
Authors: Feng Tianyi , Pan Yunmiao , Hu Sanyuan , Song Changrong , Zhong Mingwei 
Published: December 2023

Abstract
Background: In light of ongoing research elucidating the intricacies of obesity and metabolic syndrome, the role of abdominal fat (especially visceral fat) has been particularly prominent. Studies have revealed that visceral adipose tissue can accelerate the development of metabolic syndrome by releasing various bioactive compounds and hormones, such as lipocalin, leptin and interleukin.Objectives The purpose of this study was to ascertain the reliability of abdominal fat area and other parameters as valid predictors of weight loss postoperatively.Method: A retrospective analysis was performed on the clinical data of 167 patients with obesity. Among them, 105 patients who satisfied predefined inclusion and exclusion criteria were included. The parameters evaluated included total abdominal fat area(TAFA), laboratory indicators and anthropometric measurements. Weight reduction was quantified through percent total weight loss (%TWL) and percent excess weight loss (%EWL) postoperatively. Binary logistic regression analysis and receiver operating characteristic (ROC) curve analysis were employed to identify predictors of weight loss.Result: Binary logistic regression analysis emphasized that total abdominal fat area was an independent predictor of %EWL ≥ 75%(p < 0.001). Total abdominal fat area(p = 0.033) and BMI(p = 0.003) were independent predictors of %TWL ≥ 30%.Conclusion: In our cohort, weight loss at 1 year after surgery was closely related to the abdominal fat area at the preoperative third lumbar plane. Based on these results, we formulated a novel P-index,exhibiting superior predictive value for excellent weight loss.
Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation for bipolar depression (EASyS-BD): a study protocol for a multicenter, double-blind, randomized, sham-controlled trial
Authors: Noda Takamasa , Nishikawa Masako , Matsuda Yuki , Hayashi Daisuke , Kito Shinsuke 
Published: December 2023

Abstract
Background: Bipolar disorder has a long depressive episode and high risk of suicide. In clinical practice, patients often show no response to pharmacotherapy, which results in prolongation of the depressive episode. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive technique expected to serve as a treatment option for bipolar depression. For bipolar depression, a meta-analysis suggested that low-frequency stimulation to the right prefrontal cortex was possibly effective. However, a medium or large sample, randomized, double blind, sham controlled study has not yet been performed.
Objective: To examine the efficacy and safety of 1-Hz rTMS to the right prefrontal cortex in patients with treatment-resistant bipolar depression. rTMS was approved by the Ministry of Health, Labor, and Welfare as a highly advanced medical technology on March 1, 2019.
Methods: In this multicenter, double-blind, randomized, sham stimulation-controlled trial for bipolar depression, patients will be individually allocated to active or sham stimulation plus usual medication and followed up for 6 months. The conditions of stimulation by the Mag Pro R30 transcranial magnetic stimulation device (Magventure) will be a frequency of 1-Hz, intensity of 120% motor threshold, and duration of 1800 seconds to the right prefrontal cortex 5 days a week for 4 weeks during the acute treatment period. The primary endpoint will be a total change in the Montgomery-Åsberg Depression Rating Scale score during the acute treatment period.
Discussion: The outcomes of this study will inform clinical practice for the treatment of bipolar depression.
Clinical trial registration: Japan Registry of Clinical Trials, jRCTs032180138, https://jrct.niph.go.jp/latest-detail/jRCTs032180138
Screening of colorectal cancer risk factors based on Lasso regression and construction of nomogram prediction model
Authors: Hong Zhijun , Wang Ruiqi , Du Yue , Chi Huimin , Li Xiaofeng , Wang Chengfang 
Published: December 2023

Abstract
Purpose
Colorectal cancer has become the number one cancer of the digestive system and a serious risk to human health. This study explores the risk factors of colorectal cancer and provides a scientific basis for developing primary prevention measures for colorectal cancer.
Methods
Case and control groups were matched according to age (± 2) and gender (1∶1) factors, and risk factors for colorectal cancer were screened according to lasso regression and logistic regression analysis, and nomogram models were established, and subject working characteristic curves (ROC curves), calibration curves and decision curves were drawn for validation.
Results
A total of 175 cases in the case group and 175 cases in the control group were included. Lasso regression screened 23 significant variables, and logistic regression analysis showed that age, intestinal adenoma, eating meat, lamb, smoking, alcohol consumption and frequency of alcohol consumption were independent risk factors for colorectal cancer, and eating fruits, vegetables, chicken and exercise intensity were protective factors for colorectal cancer (P value < 0.05).The ROC curve analyzed the predictive value of the nomogram model with an AUC of 0.945 (95% CI: 92.2%-96.8%), with a sensitivity of 88.571 and specificity of 92.000. calibration curves and decision curves showed fair agreement and benefit of the nomogram model.
Conclusion
Colorectal cancer occurs as a result of multiple factors, and constructing a prediction model that includes relevant factors can effectively predict the risk of development and achieve primary prevention.
A Comprehensive Study on Other Disease Mortality Risk Factors in Elderly Gastric Cancer Patients Post-Curative Surgery
Authors: Ushimaru Yuki , Nagano Shinnosuke , Nishikawa Kazuhiro , Kawabata Ryohei , Takeoka Tomohira , Kitagawa Akihiro , Ohara Nobuyoshi , Tomihara Hideo , Maeda Sakae , Imazato Mitsunobu , Noura Shingo , Miyamoto Atsushi 
Published: December 2023

Abstract
Background.
With the rising incidence of gastric cancer in the elderly, there is an increasing need to understand the challenges and risks associated with surgical interventions tailored for this age group. This study aimed to identify risk factors associated with non-cancer-related mortality in elderly gastric cancer patients post-curative surgery.
Methods.
A retrospective analysis was conducted on 684 patients diagnosed with pathological Stage I - III gastric cancer who underwent curative resection at our institute between January 2012 and December 2021. The study focused on patients aged 70 years and above. Various clinical and pathological variables were assessed, and both univariate and multivariate analyses were performed to identify potential risk factors tied to non-cancer-related mortality.
Results.
Of the 603 patients who underwent curative resection, 301 were aged 70 years or older. After exclusions, 244 patients were analyzed, with 33 succumbing to non-cancer-related causes. Pneumonia was the leading cause of non-cancer-related death. Univariate analysis identified age ≥80 years, BMI <18.5, high Charlson Comorbidity Index, and the presence of overall surgical complications as potential risk factors. In the multivariate analysis, age, BMI, and overall complications retained statistical significance.
Conclusion.
Elderly gastric cancer patients post-curative surgery face a pronounced risk of non-cancer-related mortality. Factors such as advanced age, low BMI, and postoperative complications significantly influence outcomes. These findings highlight the need for preoperative nutritional interventions to enhance outcomes in this population.
Creativity is not just ideation: Controlling stimulus ambiguity and inducing convergent thinking in the alternative uses task
Authors: Witczak Olga , Krzysik Iga , Bromberek-Dyzman Katarzyna , Thierry Guillaume , Jończyk Rafał 
Published: December 2023

Abstract
In the Alternate Uses Task (AUT), a well-established creativity assessment, participants propose alternative uses for common items (e.g., a brick) within a 2-3-minute timeframe. While idea selection (convergent thinking) is involved, the emphasis is strongly on idea generation (divergent thinking). Here, we test the value of presenting a word overlapping an image compared to a word only prompt, and we introduce a novel cyclic procedure explicitly calling upon convergent thinking in the AUT. In Experiment 1, as compared to word only, word+image prompts increased idea fluency but reduced idea originality and variability within a group of native Polish speakers. Thus, word+image prompts improve AUT baselining. In Experiment 2, different participants produced as many ideas as possible within two minutes (List) or their single best idea at the end of each of three 30-second ideation cycles (Cycle). Although originality did not differ between List and Cycle overall, the first three ideas in List were rated as less creative than the ideas in Cycle, due to involvement of convergent thinking. Overall, we conclude that using disambiguating images reduces spurious interindividual variability in the AUT while introducing a convergent thinking component in the task allows us to assess creativity beyond ideation.
Job stress among nursing staff and its impact on performance in hospitals: A case study
Authors: Alraimi Ammar , Shelke Prof. Abhijeet 
Published: December 2023

Abstract
This study aimed to investigate the levels of job stress among nursing staff and its impact on their performance. The study was conducted in the largest hospital in Yemen, utilizing a case study design. A random sample of 284 nurses was drawn from a population of 1,200, and data were collected using a self-administered questionnaire that assessed job stress and performance levels. The study found that nursing staff experienced moderate job stress, with organizational structure being the most significant stressor. The nursing staff's performance was rated as excellent, and a moderate correlation between job stress and performance was observed. Notably, the work environment's job stress factor had a substantial influence on performance. These findings are consistent with previous studies that reported moderate job stress and a favorable relationship between job stress and performance among nursing staff in various settings. However, the study's emphasis on the work environment's impact on performance underscores the importance of addressing this factor to improve nursing staff performance. Hospital administrators and policymakers may benefit from implementing job-stress-reduction techniques, particularly in organizational structure and work environment aspects, as well as enhancing nursing staff resilience and coping mechanisms. This study contributes to the existing knowledge on job stress and its effect on nursing staff performance in Yemen, providing valuable insights for stakeholders and future research in different settings and cultural contexts.
Altered Choroid Plexus Volume and Association with Migraine Pathophysiology
Authors: Xiong Jianmei , Liu Mengqi , Liu Huanbo , Li Xin , Chen Zhiye 
Published: December 2023

Abstract
Background
Although compelling evidences suggest that cortical spreading depression and the trigeminovascular system activation are the main mechanisms underlying the migraigenesis, it remains “a nearly complete mystery of how the migraine starts”. Direct evidence of choroid plexus structures involved in the presumed peripheral-central interaction in migraine is exceptionally scarce and, thus, which demands further attention.
Objectives
Our objective is to assess choroid plexus volumetric changes quantitatively in episodic and chronic migraine patients versus age and sex compared normal controls, and further to elucidate the migraine pathophysiology.
Methods
Total sixty-five participants including 18 episodic migraine patients, 16 chronic migraine patients and 31 normal controls were recruited and underwent a brain MR examination with 3.0T MR strength between September 2021 to May 2023. The choroid plexus of the ventricles was segmented fully automatically on T1-weighted MRI sequences using the FreeSurfer (Version 5.3.0) software. Lateral ventricular choroid plexus volume was expressed as the ratio of choroid plexus to ipsilateral lateral ventricle volume (CP/LV). Group differences were assessed cross-sectionally. The accuracy of CP/LV for prediction of migraine was assessed using the receiver operating characteristic curves analysis.
Results
Patients with migraine were more anxious and depressive, with heavier headache burden and impaired cognitive ability. Statistical analysis revealed group differences of the CP/LV in the right side. CP/LV ration decreased in episodic migraine patients, but the CP/LV size increased with the prolongation of the disease duration. CP/LV of the right side was able to differentiate episodic migraine from controls with area under the ROC curve (AUC) 0.696 (95% CI: 0.550–0.818, sensitivity 100%, specificity 46.8%, and the cut-off value 0.0741, P < 0.05). The diagnostic efficacy was marginally higher in distinguishing chronic migraine from episodic migraine with AUC 0.715(95% CI: 0.536–0.856, sensitivity 50%, specificity 94.4% and the cut-off value 0.0725, P < 0.05).
Conclusion
Our finding suggested dynamic alteration of choroid plexus in the pathogenesis of migraine. The CP/LV volume was associated with the migraine duration. CP/LV volume can be used as a potential imaging biomarker for migraine diagnosis.