bluuebunny/crossref_metadata_2025_split huggingface dataset:
IWGDF/IDSA Guidelines on the Diagnosis and Treatment of Diabetes-related Foot Infections (IWGDF/IDSA 2023)
Authors: Senneville Éric , Albalawi Zaina , van Asten Suzanne A , Abbas Zulfiqarali G , Allison Geneve , Aragón-Sánchez Javier , Embil John M , Lavery Lawrence A , Alhasan Majdi , Oz Orhan , Uçkay Ilker , Urbančič-Rovan Vilma , Xu Zhang-Rong , Peters Edgar J G 
Published: October 2023

Abstract
The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the management and prevention of diabetes-related foot diseases since 1999. The present guideline is an update of the 2019 IWGDF guideline on the diagnosis and management of foot infections in persons with diabetes mellitus.
The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework was used for the development of this guideline. This was structured around identifying clinically relevant questions in the P(A)ICO format, determining patient-important outcomes, systematically reviewing the evidence, assessing the certainty of the evidence, and finally moving from evidence to the recommendation. This guideline was developed for healthcare professionals involved in diabetes-related foot care to inform clinical care around patient-important outcomes. Two systematic reviews from 2019 were updated to inform this guideline, and a total of 149 studies (62 new) meeting inclusion criteria were identified from the updated search and incorporated in this guideline. Updated recommendations are derived from these systematic reviews, and best practice statements made where evidence was not available. Evidence was weighed in light of benefits and harms to arrive at a recommendation. The certainty of the evidence for some recommendations was modified in this update with a more refined application of the GRADE framework centred around patient important outcomes. This is highlighted in the rationale section of this update. A note is also made where the newly identified evidence did not alter the strength or certainty of evidence for previous recommendations.
The recommendations presented here continue to cover various aspects of diagnosing soft tissue and bone infections, including the classification scheme for diagnosing infection and its severity. Guidance on how to collect microbiological samples, and how to process them to identify causative pathogens, is also outlined. Finally, we present the approach to treating foot infections in persons with diabetes, including selecting appropriate empiric and definitive antimicrobial therapy for soft tissue and bone infections; when and how to approach surgical treatment; and which adjunctive treatments may or may not affect the infectious outcomes of diabetes-related foot problems.
We believe that following these recommendations will help healthcare professionals provide better care for persons with diabetes and foot infections, prevent the number of foot and limb amputations, and reduce the patient and healthcare burden of diabetes-related foot disease.
What are the Metabolic Rates of Marine Mammals and What Factors Impact this Value: A review
Authors: Noren S R , Rosen David A S 
Published: October 2023

AbstractOver the past several decades, scientists have constructed bioenergetic models for marine mammals to assess potential population-level consequences following exposure to a disturbance, stressor, or environmental change, such as under the Population Consequences of Disturbance (pCOD) framework. The animal's metabolic rate (rate of energy expenditure) is a cornerstone for these models, yet the cryptic lifestyles of marine mammals, particularly cetaceans, have limited our ability to quantify basal (BMR) and field (FMR) metabolic rates using accepted ‘gold standard’ approaches (indirect calorimeter via oxygen consumption and doubly labeled water, respectively). Thus, alternate methods have been used to quantify marine mammal metabolic rates, such as extrapolating from known allometric relationships (e.g. Kleiber's mouse to elephant curve) and developing predictive relationships between energy expenditure and physiological or behavioral variables. To understand our current knowledge of marine mammal metabolic rates, we conducted a literature review (1900–2023) to quantify the magnitude and variation of metabolic rates across marine mammal groups. A compilation of data from studies using ‘gold standard’ methods revealed that BMR and FMR of different marine mammal species ranges from 0.2 to 3.6 and 1.1 to 6.1 x Kleiber, respectively. Mean BMR and FMR varied across taxa; for both measures odontocete levels were intermediate to higher values for otariids and lower values of phocids. Moreover, multiple intrinsic (e.g. age, sex, reproduction, molt, individual) and extrinsic (e.g. food availability, water temperature, season) factors, as well as individual behaviors (e.g. animal at water’s surface or submerged, activity level, dive effort and at-sea behaviors) impact the magnitude of these rates. This review provides scientists and managers with a range of reliable metabolic rates for several marine mammal groups as well as an understanding of the factors that influence metabolism to improve the discernment for inputs into future bioenergetic models.
Penalized quasi-likelihood estimation and model selection with parameters on the boundary of the parameter space
Authors: Nielsen Heino Bohn , Rahbek Anders 
Published: October 2023

SummaryWe consider here penalized likelihood-based estimation and model selection applied to econometric time series models, which allow for nonnegativity (boundary) constraints on some or all of the parameters. We establish that joint model selection and estimation result in standard asymptotic Gaussian distributed estimators. The results contrast with nonpenalized estimation, which, as is well-known, leads to nonstandard asymptotic distributions that depend on the unknown number of parameters on the boundary of the parameter space. We apply our results to the rich class of autoregressive conditional heteroskedastic (ARCH) models for time-varying volatility. For the ARCH models, simulations show that penalized estimation and model selection works surprisingly well, even for models with a large number of parameters. An empirical illustration for stock-market return data shows the ability of penalized estimation to select ARCH models that fit nicely the empirical autocorrelation function, and confirms the stylized fact of long-memory in such financial time series data.
Surface Gluing with Signs and Gradings in Decategorified Heegaard Floer Theory
Authors: Manion Andrew 
Published: October 2023

Abstract
A previous result about the decategorified bordered (sutured) Heegaard Floer invariants of surfaces glued together along intervals, generalizing the decategorified content of Rouquier and the author’s higher-tensor-product-based gluing theorem in cornered Heegaard Floer homology, was proved only over ${\mathbb{F}}_2$ and without gradings. In this paper we add signs and prove a graded version of the interval gluing theorem over ${\mathbb{Z}}$, enabling a more detailed comparison of these aspects of decategorified Heegaard Floer theory with modern work on non-semisimple 3d TQFTs in mathematics and physics.
A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies
Authors: Atmar Robert L , Ettayebi Khalil , Ramani Sasirekha , Neill Frederick H , Lindesmith Lisa , Baric Ralph S , Brinkman Amanda , Braun Ralph , Sherwood James , Estes Mary K 
Published: October 2023

Abstract
A GII.2 outbreak in an efficacy study of a bivalent virus-like particle norovirus vaccine, TAK-214, in healthy US adults provided an opportunity to examine GII.4 homotypic vs GII.2 heterotypic responses to vaccination and infection. Three serologic assays—virus-like particle binding, histoblood group antigen blocking, and neutralizing—were performed for each genotype. Results were highly correlated within a genotype but not between genotypes. Although the vaccine provided protection from GII.2-associated disease, little GII.2-specific neutralization occurred after vaccination. Choice of antibody assay can affect assessments of human norovirus vaccine immunogenicity.
The effect of cluster dynamical state on ram-pressure stripping
Authors: Lourenço Ana C C , Jaffé Y L , Vulcani B , Biviano A , Poggianti B , Moretti A , Kelkar K , Crossett J P , Gitti M , Smith R , Laganá T F , Gullieuszik M , Ignesti A , McGee S , Wolter A , Sonkamble S , Müller A 
Published: October 2023

ABSTRACT
Theoretical and observational studies have suggested that ram-pressure stripping (RPS) by the intracluster medium can be enhanced during cluster interactions, boosting the formation of the ‘jellyfish’ galaxies. In this work, we study the incidence of galaxies undergoing RPS in 52 clusters of different dynamical states. We use optical data from the WINGS/OmegaWINGS surveys and archival X-ray data to characterize the dynamical state of our cluster sample, applying eight different proxies. We then compute the number of RPS candidates relative to the infalling population of blue late-type galaxies within a fixed circular aperture in each cluster. We find no clear correlation between the fractions of RPS candidates and the different cluster dynamical state proxies considered. These fractions also show no apparent correlation with cluster mass. To construct a dynamical state classification closer to a merging ‘sequence’, we perform a visual classification of the dynamical states of the clusters, combining information available in optical, X-ray, and radio wavelengths. We find a mild increase in the RPS fraction in interacting clusters with respect to all other classes (including post-mergers). This mild enhancement could hint at a short-lived enhanced RPS in ongoing cluster mergers. However, our results are not statistically significant due to the low galaxy numbers. We note this is the first homogeneous attempt to quantify the effect of cluster dynamical state on RPS using a large cluster sample, but even larger (especially wider) multiwavelength surveys are needed to confirm the results.
Probing cosmic homogeneity in the Local Universe
Authors: Dias Bruno L , Avila Felipe , Bernui Armando 
Published: October 2023

ABSTRACT
We investigate the transition scale to homogeneity, RH, using as cosmic tracer the spectroscopic sample of blue galaxies from the Sloan Digital Sky Survey (SDSS). Considering the spatial distribution of the galaxy sample, we compute the two point correlation function ξ(r), the scaled counts in spheres $\mathcal {N}(\lt r)$, and the fractal dimension $\mathcal {D}_2(r)$ to quantify the homogeneity scale in the Local Universe (0.04 &lt; z &lt; 0.20). The sample in analysis is compared with random and mock catalogues with the same geometry, and the same number of synthetic cosmic objects as the data set, to calculate the covariance matrix for the errors determination. The criteria adopted for the transition-to-homogeneity follows the literature, it is attained when $\mathcal {D}_2(r)$ reaches the 1 per cent level of the limit value 3 (i.e. where it reaches 2.97) as the scale increases. We obtain RH = 70.33 ± 10.74 Mpc h−1, at the effective redshift zeff = 0.128, for a sample containing $150\, 302$ SDSS blue galaxies with 0.04 &lt; z &lt; 0.20. Additionally, we perform robustness tests by analysing the homogeneity scale in sub-volumes of the original one, obtaining coherent results; we also check for a possible artefact in our procedure examining a homogeneous synthetic data set as a pseudo-data, verifying that such systematic is absent. Because our analyses concentrate in data at low redshifts, z &lt; 0.20, we find interesting to use cosmography to calculate the radial comoving distances; therefore in this subject our analyses do not use fiducial cosmological model. For completeness, we evaluate the difference of the comoving distances estimation using cosmography and fiducial cosmology.
A new, purely photometric method for determination of resonance locations in spiral galaxies
Authors: Marchuk Alexander A , Mosenkov Aleksandr V , Chugunov Ilia V , Kostiuk Valeria S , Skryabina Maria N , Reshetnikov Vladimir P 
Published: October 2023

ABSTRACT
The knowledge of the positions of the corotation resonance in spiral arms is a key way to estimate their pattern speed, which is a fundamental parameter determining the galaxy dynamics. Various methods for its estimation have been developed, but they all demonstrate certain limitations and a lack of agreement with each other. Here, we present a new method for estimating the corotation radius. This method takes into account the shape of the profile across the arm and its width and, thus, only photometric data is needed. The significance of the method is that it can potentially be used for the farthest galaxies with measurable spiral arms. We apply it to a sample of local galaxies from Savchenko et al.(2020) and compare the obtained corotation radii with those previously measured in the literature by other methods. Our results are in good agreement with the literature. We also apply the new method to distant galaxies from the COSMOS field. For the first time, corotation locations for galaxies with photometric redshifts up to z ∼ 0.9 are measured.
Mental Health across the Early Life Course at the Intersection of Race, Skin Tone, and School Racial Context
Authors: Hargrove Taylor W 
Published: October 2023

Abstract
Prior research documents higher levels of depressive symptoms among Black Americans relative to Whites. Yet, we know less about the role of other dimensions of stratification (e.g., skin tone) in shaping mental health inequality between Black and White adults, and whether mental health trajectories by race and skin tone among Black adults are contingent upon social contexts in childhood and adolescence. To address these gaps, this study asks: (1) to what extent do self-identified race and interviewer-rated skin tone among Black respondents shape inequalities in depressive symptoms between Black and White Americans across ages 12–42? (2) Are trajectories of depressive symptoms by race and skin tone among Black respondents contingent on school racial contexts (e.g., school racial composition)? Using five waves of data from the National Longitudinal Study of Adolescent to Adult Health and growth curve models, results suggest trajectories of depressive symptoms across ages 12–42 vary by race, school racial context, and skin tone among Black respondents. Specifically, Black students rated as having very dark, dark, and medium brown skin who attended high proportion Black schools in adolescence experienced lower levels of depressive symptoms than their White and light-skinned Black counterparts, particularly across the teen years and early 20s. Conversely, attending higher proportion White schools led to increases in depressive symptoms across earlier ages for Black students, particularly those who fell within the middle of the skin color continuum. Findings highlight competing advantages and disadvantages of navigating racialized spaces in childhood/adolescence for Black Americans of different skin tones.
Age‐related flexibility of energetic metabolism in the honey bee Apis mellifera
Authors: Menail Hichem A. , Cormier Simon B. , Léger Adèle , Robichaud Samuel , Hebert‐Chatelain Etienne , Lamarre Simon G. , Pichaud Nicolas 
Published: October 2023

AbstractThe mechanisms that underpin aging are still elusive. In this study, we suggest that the ability of mitochondria to oxidize different substrates, which is known as metabolic flexibility, is involved in this process. To verify our hypothesis, we used honey bees (Apis mellifera carnica) at different ages, to assess mitochondrial oxygen consumption and enzymatic activities of key enzymes of the energetic metabolism as well as ATP5A1 content (subunit of ATP synthase) and adenylic energy charge (AEC). We also measured mRNA abundance of genes involved in mitochondrial functions and the antioxidant system. Our results demonstrated that mitochondrial respiration increased with age and favored respiration through complexes I and II of the electron transport system (ETS) while glycerol‐3‐phosphate (G3P) oxidation was relatively decreased. In addition, glycolytic, tricarboxylic acid cycle and ETS enzymatic activities increased, which was associated with higher ATP5A1 content and AEC. Furthermore, we detected an early decrease in the mRNA abundance of subunits of NADH ubiquinone oxidoreductase subunit B2 (NDUFB2, complex I), mitochondrial cytochrome b (CYTB, complex III) of the ETS as well as superoxide dismutase 1 and a later decrease for vitellogenin, catalase and mitochondrial cytochrome c oxidase subunit 1 (COX1, complex IV). Thus, our study suggests that the energetic metabolism is optimized with aging in honey bees, mainly through quantitative and qualitative mitochondrial changes, rather than showing signs of senescence. Moreover, aging modulated metabolic flexibility, which might reflect an underpinning mechanism that explains lifespan disparities between the different castes of worker bees.
Trained immunity in diabetes and hyperlipidemia: Emerging opportunities to target cardiovascular complications and design new therapies
Authors: Robinson Katherine A. , Akbar Naveed , Baidžajevas Kajus , Choudhury Robin P. 
Published: October 2023

AbstractSome metabolic diseases, such as diabetes and hyperlipidemia, are associated with a state of inflammation, which adversely affects cardiovascular health. Emerging evidence suggests that long‐term hyperactivation of innate immune cells and their bone marrow progenitors, termed trained immunity, functions to accelerate atherosclerosis and its complications in cardiometabolic diseases. This review will focus on how trained immunity is established, particularly through metabolic and epigenetic reprogramming, to cause persistent and deleterious changes in immune cell function, even after the original stimulus has been corrected or removed. Understanding the mechanisms driving maladaptive trained immunity and its fundamental contribution to cardiovascular disease might enable the development of novel disease‐modifying therapeutics for the reduction in cardiovascular risk in diabetes, hyperlipidemia, and related cardiometabolic states.
Inadequate Lymph Node Yield: An Inadequate Indication for Adjuvant Chemotherapy in Stage II Colon Cancer
Authors: Zambeli-Ljepović Alan , Hoffman Daniel , Barnes Katherine E. , Romero-Hernandez Fernanda , Ashraf Ganjouei Amir , Adam Mohamed A. , Sarin Ankit 
Published: October 2023

Background:
Optimal therapy for stage II colon cancer remains unclear, and national guidelines recommend “consideration” of adjuvant chemotherapy (ACT) in the presence of high-risk features, including inadequate lymph node yield (LNY, <12 nodes). This study aims to determine whether the survival benefit of ACT in stage II disease varies based on the adequacy of LNY.

Methods:
We used the National Cancer Database (NCDB) to identify adults who underwent resection for a single primary T3 or T4 colon cancer between 2006 and 2018. Multivariable logistic regression tested for associations between ACT and prespecified demographic and clinical characteristics, including the adequacy of LNY. We used Cox proportional hazards models to assess overall survival and restricted cubic splines to estimate the optimal LNY threshold to dichotomize patients based on overall survival.

Results:
Unadjusted 5- and 10-year survival rates were 84% and 75%, respectively, among patients who received ACT and 70% and 50% among patients who did not (log-rank P < 0.01). Inadequate LNY was independently associated with both receipt of ACT (odds ratios, 1.50; P < 0.01) and decreased overall survival [hazard ratio (HR), 1.56; P < 0.01]. ACT was independently associated with improved survival (HR, 0.67; P < 0.01); this effect size did not change based on the adequacy of LNY (interaction P = 0.41). Results were robust to re-analysis with our cohort-optimized threshold of 18 lymph nodes.

Conclusions:
Consistent with contemporary guidelines, patients with inadequate LNY are more likely to receive ACT. LNY adequacy is an independent prognostic factor but, in isolation, should not dictate whether patients receive ACT.
Pronation Reveals a Heterogeneous Response of Global and Regional Respiratory Mechanics in Patients With Acute Hypoxemic Respiratory Failure
Authors: Morais Caio C.A. , Alcala Glasiele , De Santis Santiago Roberta R. , Valsecchi Carlo , Diaz Eduardo , Wanderley Hatus , Fakhr Bijan Safaee , Di Fenza Raffaele , Gianni Stefano , Foote Sara , Chang Marvin G. , Bittner Edward A. , Carroll Ryan W. , Costa Eduardo L.V. , Amato Marcelo B.P. , Berra Lorenzo 
Published: October 2023

OBJECTIVES:
Experimental models suggest that prone position and positive end-expiratory pressure (PEEP) homogenize ventral–dorsal ventilation distribution and regional respiratory compliance. However, this response still needs confirmation on humans. Therefore, this study aimed to assess the changes in global and regional respiratory mechanics in supine and prone positions over a range of PEEP levels in acute respiratory distress syndrome (ARDS) patients.

DESIGN:
A prospective cohort study.

PATIENTS:
Twenty-two intubated patients with ARDS caused by COVID-19 pneumonia.

INTERVENTIONS:
Electrical impedance tomography and esophageal manometry were applied during PEEP titrations from 20 cm H2O to 6 cm H2O in supine and prone positions.

MEASUREMENTS:
Global respiratory system compliance (Crs), chest wall compliance, regional lung compliance, ventilation distribution in supine and prone positions.

MAIN RESULTS:
Compared with supine position, the maximum level of Crs changed after prone position in 59% of ARDS patients (n = 13), of which the Crs decreased in 32% (n = 7) and increased in 27% (n = 6). To reach maximum Crs after pronation, PEEP was changed in 45% of the patients by at least 4 cm H2O. After pronation, the ventilation and compliance of the dorsal region did not consistently change in the entire sample of patients, increasing specifically in a subgroup of patients who showed a positive change in Crs when transitioning from supine to prone position. These combined changes in ventilation and compliance suggest dorsal recruitment postpronation. In addition, the subgroup with increased Crs postpronation demonstrated the most pronounced difference between dorsal and ventral ventilation distribution from supine to prone position (p = 0.01), indicating heterogeneous ventilation distribution in prone position.

CONCLUSIONS:
Prone position modifies global respiratory compliance in most patients with ARDS. Only a subgroup of patients with a positive change in Crs postpronation presented a consistent improvement in dorsal ventilation and compliance. These data suggest that the response to pronation on global and regional mechanics can vary among ARDS patients, with some patients presenting more dorsal lung recruitment than others.