bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal diagnosis of chromosome 4 mosaicism: Prognostic role of cytogenetic, molecular, and ultrasound/MRI characterization
Authors: Gentile Mattia , Volpe Paolo , Cariola Filomena , Carlo Antonio Di , Marotta Vincenzo , Buonadonna Antonia Lucia , Boscia Filippo Maria 
Published: June 2005

AbstractTrisomy 4 mosaicism is extremely rare: herein we report the cytogenetic and molecular characterization and prenatal US findings of a case diagnosed prenatally. The diagnosis of level III mosaicism was established in cultured amniotic fluid cells (22.5%). At 22 weeks gestation, micrognathia and hypotelorism were suspected at 2‐D sonography, and confirmed at 3‐D examination. In addition, 2‐D US showed cerebellar hypoplasia associated with borderline ventriculomegaly (confirmed at magnetic resonance imaging, MRI), spine deformity (hemivertebra), and a complete atrioventricular septal defect (AVSD). The pregnancy was terminated. Trisomy 4 mosaicism was confirmed in placental and fetal skin cultured cells. The cord blood karyotype was normal. Molecular analysis excluded uniparental disomy of chromosome 4, and indicated that the trisomy 4 was of maternal meiotic origin. In presence of chromosome 4 mosaicism, accurate fetal sonography and echocardiography are mandatory. Low level mosaicism and normal echographic examinations seem to be associated with good prognosis. In postnatal life, chromosome 4 mosaicism should be suspected, and cytogenetic analysis proposed of further tissues (i.e., skin), in presence of craniofacial dysmorphism, cardiac defects, and abnormal hands/feet, even if mental development is appropriate or only slightly impaired. © 2005 Wiley‐Liss, Inc.
Maladaptive behaviors and risk factors among the genetic subtypes of Prader–Willi syndrome
Authors: Hartley Sigan L. , MacLean William E. , Butler Merlin G. , Zarcone Jennifer , Thompson Travis 
Published: June 2005

AbstractMaladaptive behaviors among 65 people with Prader–Willi syndrome were assessed using the Reiss Screen for maladaptive behaviors. Young adults in their twenties were more likely to display aggressive behavior than adolescents and older adults. Differences in maladaptive behaviors between the typical deletion and uniparental disomy (UPD) subtypes were evaluated. The typical deletion subtype had higher self‐injury and stealing scores than the UPD subtype. Subject characteristics were differentially related to maladaptive behavior among the typical deletion and UPD subtypes. Differences in maladaptive behavior were also examined between the typical deletion type I and type II subtypes. The type I deletion subtype had greater physical depression scores than the type II deletion subtype. The Reiss Screen cut‐off scores were used to determine whether differences occurred between the subtypes at a clinically significant level. These findings offer insight into the health care needs of people with PWS. © 2005 Wiley‐Liss, Inc.
Terminal deletion of 6p results in a recognizable phenotype
Authors: Lin Ruth J. , Cherry Athena M. , Chen Kelly C. , Lyons Michael , Hoyme H. Eugene , Hudgins Louanne 
Published: June 2005

AbstractWith improved cytogenetic techniques, small deletions and duplications are being identified with increased frequency. We report four cases with terminal deletions involving the 6p24‐ and 6p25‐pter chromosomal segment who exhibit a distinct, recognizable pattern of malformations including hypertelorism, downslanting palpebral fissures, flat nasal bridge, Dandy–Walker malformation/variant, congenital heart defects, anterior eye‐chamber abnormalities, hearing loss, and developmental delay. We also compare the clinical aspects of these patients to those of previously reported cases in the literature with similar terminal deletions of chromosome 6p. Routine chromosome analysis can miss this deletion, therefore, high‐resolution chromosome analysis is indicated for individuals who exhibit these distinct features. Furthermore, individuals with this deletion should have an ophthalmologic exam, cardiac evaluation, head imaging, renal ultrasound, and formal hearing evaluation. © 2005 Wiley‐Liss, Inc.
PTPN11 mutations play a minor role in isolated congenital heart disease
Authors: Weismann Constance G. , Hager A. , Kaemmerer H. , Maslen C. L. , Morris Cynthia D. , Schranz D. , Kreuder J. , Gelb B.D. 
Published: June 2005

AbstractPTPN11 missense mutations cause approximately 50% of Noonan syndrome, an autosomal dominant disorder presenting with various congenital heart defects, most commonly valvar pulmonary stenosis, and hypertrophic cardiomyopathy. Atrioventricular septal defects and coarctation of the aorta occur in 15% and 9%, respectively. The aim of this study was to determine if PTPN11 mutations exist in non‐syndromic patients with these two relevant forms of congenital heart disease. The 15 coding PTPN11 exons and their intron boundaries from subjects with atrioventricular septal defects (n = 24) and coarctation of the aorta (n = 157) were analyzed using denaturing high performance liquid chromatography and sequenced if abnormal. One subject with an atrioventricular septal defect but no other known medical problems had a c.127C > T transition in exon 2, predicting a p.L43F substitution. This mutation affected the phosphotyrosine‐binding region in the N‐terminal src homology 2 domain and was close to a Noonan syndrome mutation (p.T42A). An otherwise healthy patient with aortic coarctation had a silent c.540C > T change in exon 5 corresponding to p.D180D. Our study showed that PTPN11 mutations are rarely found in two isolated forms of congenital heart disease that commonly occur in Noonan syndrome. The p.L43F mutation belongs to a rare class of PTPN11 mutations altering the phosphotyrosine‐binding region. These mutations are not predicted to alter the autoinhibition of the PTPN11 protein product, SHP‐2, which is the mechanism for the vast majority of mutations causing Noonan syndrome. Future studies will be directed towards understanding these rare phosphotyrosine binding region mutants. © 2005 Wiley‐Liss, Inc.
Sex differences in scent marking in Propithecus edwardsi of Ranomafana National Park, Madagascar
Authors: Pochron Sharon T. , Morelli Toni Lyn , Scirbona Jessica , Wright Patricia C. 
Published: June 2005

AbstractIn this study we compared the scent‐marking rates of females with those of males. Specifically, we examined the ability of season, dominance status, and natal status to explain the frequency of scent marking in female sifakas living wild in Ranomafana National Park, Madagascar, and compared the results with those published for males [Pochron et al., American Journal of Primatology, in press]. We also sought to determine whether vulnerability to infanticide affects marking frequency in adults of either sex, and whether female reproductive status affects female marking behavior. We found that males marked at twice the rate of females, and like males, females in single‐female groups marked at the highest rates. Dominant females and non‐natal females marked at higher rates than did subordinate females and natal females, a pattern also seen in males. This suggests that scent marks may convey important information about status. Neither females nor males varied their marking frequency with the presence of vulnerable infants. Females did not alter marking frequency with reproductive state, and like males, they marked at higher rates in the period prior to the mating season than they did in the mating season itself. This implies that females may use scent marks more for intrasexual aggression or territoriality than for mate attraction. Am. J. Primatol. 66:97–110, 2005. © 2005 Wiley‐Liss, Inc.
Identification of Helicobacter sp. in gastric mucosa from captive marmosets (Callithrix sp.; callitrichidae, primates)
Authors: de Mello Marcela Freire Vallim , Monteiro Ana Beatriz Soares , Fonseca Eliene Carvalho , Pissinatti Alcides , Ferreira Ana Maria Reis 
Published: June 2005

AbstractThe aim of this study was to identify the presence of Helicobacter sp. in the gastric mucosa of captive marmosets (Callithrix sp.). Histologic specimens from the fundic, corpus, and antral gastric regions of six Callithrix jacchus, 12 C. kuhli, and 12 C. geoffroyi specimens were evaluated. The sections were stained with hematoxylin‐eosin (H&E) and the Warthin‐Starry silver impregnation method, and immunostained with rabbit anti‐H. pylori polyclonal antibody. Helicobacter‐like organisms (HLOs) and coccoid forms were present in silver‐stained sections from 29 stomachs, whereas immunohistochemistry (IHC) tests revealed bacterial aggregates in 15 stomachs. No statistical difference relative to the presence of Helicobacter sp. was found among the gastric regions or marmoset species. Gastric lesions were found in the groups of marmosets that had positive and negative IHC results, but no correlation between inflammation and Helicobacter sp. infection was established. These findings demonstrate that marmosets are susceptible to naturally‐occurring Helicobacter sp. infection, and open the way to the development of comparative studies on Helicobacter sp. infection in humans. Am. J. Primatol. 66:111–118, 2005. © 2005 Wiley‐Liss, Inc.
Testosterone and energetics in wild chimpanzees (Pan troglodytes schweinfurthii)
Authors: Muller Martin N. , Wrangham Richard W. 
Published: June 2005

AbstractOvarian function in female hominoids is sensitive to both energy flux and energy balance, resulting in a reduced probability of conception during periods when a successful reproductive outcome is less likely. However, the extent to which energetic factors constrain gonadal function in male hominoids is not clear. We examined the effects of both acute and chronic variation in energy availability on urinary testosterone (T) levels in adult male chimpanzees. Acute changes in energy availability, which were assayed by means of observational data on feeding behavior, did not result in decreased T production for 11 individuals at Kibale National Park, Uganda. Chronic energy shortages, on the other hand, may be associated with lower T levels in this population. Adult males in Kibale (n=11), who maintain suboptimal access to energy, exhibit significantly lower urinary T levels than males in captivity (n=11), who are more sedentary and better fed. These results suggest that data on hormonal function in captive chimpanzees should be interpreted with caution because individuals may produce T at levels well above those that are typical in the wild. They also suggest that short‐term variations in T levels in male hominoids are more likely to be explained by social factors than by energetic ones. Am. J. Primatol. 66:119–130, 2005. © 2005 Wiley‐Liss, Inc.
Proximity and estrous synchrony in Mahale chimpanzees
Authors: Matsumoto‐Oda Akiko , Kasuya Eiiti 
Published: June 2005

AbstractSince McClintock [Nature 229:244–255, 1971] first reported menstrual synchrony in women, a number of studies have reported similar phenomena. Many researchers have suggested that one of the proximate factors leading to synchrony is spatial proximity among females (e.g., close friends or roommates). However, most studies on menstrual synchrony have been conducted in limited spaces, and it remains to be determined whether controlled environments, such as those used in experiments, actually exist in the wild. In this study, we analyzed the relationship between proximity and estrous synchrony using data from wild female chimpanzees at Mahale, Tanzania. In the cycling females, we observed two pairs that spent a large amount of time together. We compared the estrous synchrony indices (ESIs) between these two pairs and the other females. Our results showed that the ESIs of the high‐proximity pairs did not differ from those of other pairs. Am. J. Primatol. 66:159–166, 2005. © 2005 Wiley‐Liss, Inc.
Disproportionate participation by age/sex classes in aggressive interactions between long‐tailed macaques (Macaca fascicularis) and human tourists at Padangtegal monkey forest, Bali, Indonesia
Authors: Fuentes Agustín , Gamerl Scott 
Published: June 2005

AbstractWe observed 420 aggressive interactions between tourists and Macaca fascicularis at the Padangtegal Wanara Wana Temple forest site in Bali, Indonesia, during the months of June and July 2001. The data collected included patterns of aggression, presence or absence of food, and demographic information on resident macaques and human visitors. Analyses of the interactions suggest that macaques respond differentially to humans according to the age/sex classes involved. Additionally, adult and subadult male macaques participated in more aggressive behaviors than expected, while adult female macaques and immatures participated in such behaviors less than expected. These variations in interaction patterns between macaques and tourists may have substantial implications for management issues and the potential for pathogen transmission. Am. J. Primatol. 66:197–204, 2005. © 2005 Wiley‐Liss, Inc.
Exploration of the Hellenistic fortification complex at Asea using a multigeophysical prospection approach
Authors: Dogan M. , Papamarinopoulos S. 
Published: June 2005

AbstractMulti‐electrode resistivity tomography, twin‐probe and ground‐penetrating radar (GPR) geophysical techniques were applied at the multicultural archaeological site of Asea as a collaboration between the Swedish Institute at Athens and the University of Patras. This work presents the geophysical results of Grid 16 where a subsurface polygonal city wall was discovered in the field season 2002. It is intended to explore especially the location, depth and trending direction of the city wall to contribute progressive studies of methods applied to subsurface walls. The survey was performed using the Geopulse imager, with 25 electrodes at 0.8 m electrode spacing, Geoscan RM4 and SIR‐10 GPR systems. The surveys used a 20×20 m grid mode and the Wenner–Schlumberger hybrid array was selected for resistivity measurement. The Hellenistic period city wall was imaged in the south–north direction in a well‐preserved situation below subsurface. The results revealed that the resistivity method can provide a clear pseudo‐image of a medium to large size wall with high accuracy on archaeological sites. Interpretation of GPR three‐dimensional depth‐slices identified the position, dimension and orientation of the subsurface city wall. Copyright © 2005 John Wiley & Sons, Ltd.
Geophysical investigation of the site of the former monastic settlement, Clonard, County Meath, Ireland
Authors: Gibson Paul J. , George Dorothy M. 
Published: June 2005

AbstractClonard, in County Meath, Ireland was a major ecclesiastical centre from the early sixth century to the twelfth century and buildings associated with the monastery were in existence until the late eighteenth century. However, today no extant buildings or features associated with the monastery are known. The geophysical investigation undertaken in this project has uncovered many anomalies which may be related to the monastic settlement at Clonard. A significant number of linear anomalies have been detected east of St Finian's church using magnetic gradiometry and twin electrode resistance surveying. Many of these anomalies are probably field boundaries; however, a much greater diversity of geophysical responses is located south and west of St Finian's church. A subsquare enclosure of 60 m sides is adjacent to a 300 m long palaeochannel. A fine network of intersecting low resistance anomalies probably represent former artificial drainage channels. Three large areas associated with anomalous magnetic readings were located which might indicate sites of human activity. In addition, there are four distinct zones which have large concentrations of high resistance values suggesting the presence of walls or buildings. Resistivity and ground‐penetrating radar depth slices show that one of these zones has characteristics which indicate the presence of an east–west aligned building approximately 7 m wide in a north–south direction and about 15 m long in an east–west direction. Copyright © 2005 John Wiley & Sons, Ltd.
A New Ligand for Immunoglobulin G Subdomains by Screening of a Synthetic Peptide Library
Authors: Verdoliva Antonio , Marasco Daniela , De Capua Antonia , Saporito Angela , Bellofiore Piero , Manfredi Vincenzo , Fattorusso Roberto , Pedone Carlo , Ruvo Menotti 
Published: June 2005

AbstractBy screening a synthetic peptide library of general formula (NH2‐Cys1‐X2‐X3‐X4)2‐Lys‐Gly‐OH, a disulfide‐bridged cyclic peptide, where X2‐X3‐X4 is the tripeptide Phe‐His‐His, has been selected as a ligand for immunoglobulin G (IgG). The peptide, after a preliminary chromatographic characterization, has proved useful as a new affinity ligand for the purification of polyclonal as well as monoclonal antibodies from biological fluids, with recovery yields of up to 90 % (90 % purity). The ligand is able to bind antibody fragments containing both Fab and Fc from different antibody isotypes, a fact suggesting the presence of at least two different antibody‐binding sites. While the recognition site on Fab is unknown, comparative binding studies with Fc, in association with the striking similarities of the peptide (named Fc‐receptor mimetic, FcRM) with a region of the human FcγRIII receptor, strongly indicate that the peptide could recognize a short amino acid stretch of the lower hinge region, which has a key role in autoimmune disease triggering. The unique properties make the ligand attractive for both the purification of antibody fragments and as a lead for the generation of Fc‐receptor antagonists.
X‐Ray Crystal Structures of [XF6][Sb2F11] (X: Cl, Br, I); 35,37Cl, 79,81Br, and 127I NMR Studies and Electronic Structure Calculations of the XF6+ Cations.
Authors: Lehmann John F. , Schrobilgen Gary J. , Christe Karl O. , Kornath Andreas , Suontamo Reijo J. 
Published: June 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Development of Highly Stereoselective Asymmetric 6π‐Azaelectrocyclization of Conformationally Flexible Linear 1‐Azatrienes. From Determination of Multifunctional Chiral Amines, 7‐Alkyl cis‐1‐Amino‐2‐indanols, to Application as a New Synthetic Strategy: Formal Synthesis of 20‐Epiuleine.
Authors: Tanaka Katsunori , Kobayashi Toyoharu , Mori Hajime , Katsumura Shigeo 
Published: June 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Scope and Utility of CsOH×H2O in Amination Reactions via Direct Coupling of Aryl Halides and sec‐Alicyclic Amines.
Authors: Varala Ravi , Ramu E. , Alam M. Mujahid , Adapa Srinivas R. 
Published: June 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Lewis Acid Mediated Protocol for the Protection of Aryl Amines as Their Boc‐Derivatives.
Authors: Bartoli Giuseppe , Bosco Marcella , Locatelli Manuela , Marcantoni Enrico , Massaccesi Massimo , Melchiorre Paolo , Sambri Letizia 
Published: June 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Study of a New Rate Increasing “Base Effect” in the Palladium‐Catalyzed Amination of Aryl Iodides.
Authors: Meyers Caroline , Maes Bert U. W. , Loones Kristof T. J. , Bal Gunther , Lemiere Guy L. F. , Dommisse Roger A. 
Published: June 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Unusual Reaction of 1‐Acetyl‐5‐bromo‐1H‐indole‐2,3‐dione with Ethyl (Triphenylphosphoranylidene)acetate.
Authors: Kozminykh V. O. , Lomidze K. Sh. , Kozminykh E. N. , Berezin A. N. 
Published: June 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Efficient Synthesis of 1,2,4‐Triazolo[5,1‐b]quinazolin‐9(3H)‐ones via a Tandem Aza‐Wittig/Heterocumulene‐Mediated Annulation.
Authors: Ding Ming‐Wu , Chen Yun‐Feng , Huang Nian‐Yu 
Published: June 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Modeling of the D2 Dopamine Receptor Arylpiperazine Binding Site for 1‐{2‐[5‐(1H‐Benzimidazole‐2‐thione)]ethyl}‐4‐arylpiperazines.
Authors: Sukalovic Vladimir , Zlatovic Mario , Andric Deana , Roglic Goran , Kostic‐Rajacic Sladjana , Soskic Vukic 
Published: June 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Selective tert‐Butyl Ester Deprotection in the Presence of Acid Labile Protecting Groups with Use of ZnBr2.
Authors: Kaul Ramesh , Brouillette Yann , Sajjadi Zohreh , Hansford Karl A. , Lubell William D. 
Published: June 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A corotational finite element formulation for the analysis of planar beams
Authors: Urthaler Y. , Reddy J. N. 
Published: June 2005

AbstractAn efficient and accurate locking‐free corotational beam finite element for the analysis of large displacements and small‐strain problems is developed in this paper. Three different finite element models based on three different beam theories, namely, the Euler–Bernoulli, Timoshenko, and simplified Reddy theories are presented. In order to develop a single corotational finite element that incorporates the kinematics of all three theories, the unified linear finite element model of beams developed by Reddy (Comm. Numer. Meth. Eng. 1997; 13:495–510) is included in the formulation. An incremental iterative technique based on the Newton–Raphson method is employed for the solution of the non‐linear equilibrium equations. Numerical examples that demonstrate the efficiency and large rotation capability of the corotational formulation are presented. The element is validated by comparisons with exact and/or approximate solutions available in the literature. Very good agreement is found in all cases. Copyright © 2005 John Wiley & Sons, Ltd.
Computation of the logarithm of Bessel functions of complex argument
Authors: Rothwell E. J. 
Published: June 2005

AbstractAlgorithms for computing the logarithm of Bessel functions of complex argument and integer order are presented. These algorithms will be useful when direct evaluation of the Bessel function causes computer overflow or underflow. Several numerical results are presented, and an example of radiation by a line source is given. Copyright © 2005 John Wiley & Sons, Ltd.
Why two kinds of color order systems are necessary?
Authors: Nayatani Yoshinobu 
Published: June 2005

AbstractTwo kinds of color order systems—Type I (Munsell system, its representative) and Type II (Swedish Natural Colour System (NCS), its representative)—are widely used for systematic ordering of object colors. The reasons are clarified why two kinds of systems are necessary. The reasons are (1)the problem caused by the use of the present CIE photometric and colorimetric system and (2)the neglection of chromatic strength (CS) of each hue to perceived color attributes. In addition, a comparison is made between NCS and Nayatani Theoretical (NT) systems, which are in the same category of color order system–Type II. The importance of CS function is clarified in the comparison of the three color order systems studied. Special features of the three color order systems (Munsell, NCS, and NT) are described in detail. © 2005 Wiley Periodicals, Inc. Col Res Appl, 30, 295–303, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/col.20127
Grafting Poly(4‐vinylpyridine) with a Second‐Order Nonlinear Optically Active Nickel(II) Chromophore
Authors: Caruso Ugo , Centore Roberto , Panunzi Barbara , Roviello Antonio , Tuzi Angela 
Published: June 2005

AbstractMetal‐containing polymers are obtained by grafting commercial poly(4‐vinylpyridine) (average molecular weight 60000 or 160000) with a NiII chromophore complex. The metal‐containing chromophore was obtained from a tridentate benzoylhydrazine ligand. Chromophore fragments were grafted onto the polymer by formation of a coordinative bond between the metal and the pyridinic nitrogen. Two acentric mononuclear NiII complexes containing pyridine as an additional ligand, in a square‐planar or in an octahedral environment, have been prepared and characterised also by single‐crystal X‐ray analysis. The chemical and thermal properties of the model complexes and of the grafted polymers were examined and compared with those of CuII‐ and PdII‐based ones, in particular with reference to their NLO properties. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)