bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Synthesis of Aspirin-chalcone Mimic Conjugates as Potential Anticancer
Agents
Authors: Mohamed-Ezzat Reham A. , Srour Aladdin M. 
Published: January 2024

Background:
Extensive research has been conducted on aspirin, a widely recognized NSAID medication,
regarding its potential as an anticancer agent. Studies have revealed its ability to trigger cell death in different
types of cancer cells.

Methods:
A set of aspirin-chalcone mimic conjugates 5a-k and 6a-d utilizing the freshly prepared acid chloride
of aspirin moiety has been designed and synthesized. To evaluate the newly developed compounds, the NCI 60-
cell line panel was employed to assess their anti-proliferative properties. Subsequently, cell cycle analysis was
conducted along with an examination of the compounds' impact on the levels of p53, Bax, Bcl-2, active caspase-
3, and their inhibition mechanism of tubulin polymerization.

Results:
Derivative 6c displayed the best anticancer activity among the tested series while 6d was the best against
breast cancer MDA-MB-468, therefore both of them were selected for the 5-dose stage, however, targeting
MDA-MB-468, PI-flow cytometry of compound 6d proved the triggered cell growth arrest at the G1/S phase
avoiding the mitotic cycle in MDA-MB-468 cells. Similarly, the upregulation of oncogenic parameters such as
caspase-3, p53, and Bax/Bcl-2, along with the inhibition of PARP-1 enzyme level, was observed with compound
6d. This compound also exhibited a significant ability to induce apoptosis and disrupt the intracellular microtubule
network through a promising activity as a tubulin polymerization inhibitor with IC50 = 1.065 ± 0.024 ng/ml.
Furthermore, to examine the manner in which compound 6d binds to the active pocket of the tubulin polymerization
enzyme, a molecular docking study was conducted.

Conclusion:
The study indicated that compound 6d could be a powerful microtubule-destabilizing agent. Therefore,
further research on 6d could be worthwhile.
Differential Gene Expression and Immune Cell Infiltration in Patients with
Steroid-induced Necrosis of the Femoral Head
Authors: Ren Guowu , Han Jie , Mo Jian , Xu Zhiwei , Feng Xinjian , Chen Feng , Wu Yukun , Peng Qinglin 
Published: January 2024

Objective:
The study aimed to study the differential gene expression and immune cell
infiltration in patients with steroid-induced necrosis of the femoral head (SANFH), identify the
key genes and immune cells of SANFH, and explore the relationship between immune cells and
SANFH.

Methods:
The high-throughput gene chip dataset GSE123568 was downloaded from the GEO
database, and the differential gene expression was analyzed with the R language. The STRING
database and Cytoscape software were used to analyze the protein interaction network and
screen key genes, and enrichment analysis was carried out on key genes. The infiltration of immune
cells in SANFH patients was analyzed and verified by immunohistochemistry.

Results:
EP300, TRAF6, STAT1, JAK1, CASP8, and JAK2 are key genes in the pathogenesis
of SANFH, which mainly involve myeloid cell differentiation, cytokine-mediated signaling
pathway, tumor necrosis factor-mediated signaling pathway, and cellular response to tumor necrosis
factor through JAK-STAT, NOD-like receptor, toll-like receptor, and other signaling
pathways, leading to the occurrence of diseases; immune infiltration and immunohistochemical
results have shown the expression of memory B cells and activated dendritic cells as reduced in
SANFH patients, while in the same SANFH samples, M1 macrophages have been positively
correlated with monocytes, and neutrophils have been negatively correlated with monocytes
expression.

Conclusion:
EP300, TRAF6, STAT1, JAK1, CASP8, and JAK2 have exhibited significant differences
in SANFH (spontaneous osteonecrosis of the femoral head). Memory B cells, activated
dendritic cells, M1 macrophages, monocytes, and neutrophils have shown abnormal expression
in SANFH.
CT-guided Percutaneous Microwave Ablation Combined with Local
Radiotherapy or Chemotherapy of Malignant Pulmonary Tumors
Authors: Xu Rongde , Chen Jingjing , Chen Daohua , Zhang Xiaobo , Cui Wei , Deng Yi , Sun Danxiong , Yuan Bing , Li Jing 
Published: January 2024

Background and Objective:
The study aimed to investigate the clinical efficacy of
CT-guided microwave ablation (MWA) combined with 125I seed implantation or bronchial arterial
infusion (BAI) chemotherapy in the treatment of malignant pulmonary tumors.

Methods:
A total of 56 patients who underwent MWA, MWA combined with 125I particle implantation,
or MWA combined with BAI chemotherapy for advanced lung cancer or metastatic
lung cancer from January 2015 to June 2021 in Guangdong Provincial People’s Hospital were
enrolled. Among them, 21 patients were treated with MWA (MWA), 18 with MWA combined
with 125I seed implantation (MWA+125I), and 17 with MWA combined with BAI chemotherapy
(MWA+BAI). The short-term outcomes, complications, Eastern Cooperative Oncology Group
(ECOG) performance score (Zubrod-ECOG-WHO, ZPS), survival, and factors related to survival
were compared between the three groups.

Results:
The response rate of the MWA group (9.52%) was significantly lower than that of the
MWA+125I group (50.00%) and MWA+BAI chemotherapy group (47.06%), and the differences
were statistically significant (p < 0.05). The incidence of complications in the MWA,
MWA+125I, and MWA+BAI chemotherapy groups was 47.62%, 55.56%, and 52.94%, respectively,
with no significant difference (p > 0.05). Three months after the treatment, the ZPS of
the MWA+125I and MWA+BAI chemotherapy groups was significantly lower than before
treatment and significantly lower than that of the MWA group in the same period; the differences
were statistically significant (p < 0.05). The median survival time of the MWA+125I group
was 18 (9.983, 26.017) months and that of the MWA+BAI chemotherapy group was 21 (0.465,
41.535) months, both of which were higher than that of the MWA group [11 (6.686, 15.314)
months]; the differences were statistically significant (p < 0.05). Cox regression analysis was
performed on the factors related to survival and revealed treatment mode as a protective factor
[HR = 0.433, 95% CI = (0.191, 0.984), p = 0.046]. Other factors, such as gender, age, and tumor
size, did not independently affect survival.

Conclusion:
CT-guided MWA combined with 125I seed implantation and MWA combined with
BAI chemotherapy are safe and effective for the treatment of advanced lung cancer and metastatic
lung cancer, and can control tumor progression and prolong survival time.
HealthySMS Text Messaging System Adjunct to Adolescent Group Cognitive Behavioral Therapy in the Context of COVID-19 (Let’s Text!): Pilot Feasibility and Acceptability Study
Authors: Haack Lauren M , Armstrong Courtney C , Travis Kate , Aguilera Adrian , Darrow Sabrina M 
Published: January 2024

Background
The widespread occurrence and devastating impact of adolescent depression warrant health service research focused on feasible and acceptable digital health tools to supplement evidence-based intervention (EBI) efforts, particularly in the context of shelter-in-place guidelines disrupting youth socialization and service use in the wake of the COVID-19 pandemic. Given the promise of SMS text message interventions to enhance EBI engagement, our team developed the HealthySMS system as an adjunct to one of the most empirically supported interventions for adolescent depression: cognitive behavioral therapy (CBT) group services. The system sends daily SMS text messages requesting responses assessing mood, thoughts, and activities; weekly attendance reminder messages; daily tips about adherence (eg, a prompt for activity completion); and personalized responses based on participants’ texts.

Objective
This study aims to evaluate the feasibility and acceptability of HealthySMS in a real-world setting and explore potential mechanisms of change in EBI engagement, before evaluating the system’s impact on adolescents’ group CBT engagement and, ultimately, depression outcomes.

Methods
Over the course of 2020, we invited all 20 adolescents receiving CBT group services for depression at an outpatient psychiatry clinic to enroll in our HealthySMS study; ultimately, 17 (85%) adolescents agreed to participate. We tracked participant initiation and engagement with the HealthySMS system as well as the content of SMS text message responses to HealthySMS. We also invited each participant to engage in a semistructured interview to gather additional qualitative inputs on the system.

Results
All (n=17, 100%) research participants invited agreed to receive HealthySMS messages, and 94% (16/17) of the participants maintained use during the first month without opting out. We uncovered meaningful qualitative themes regarding the feasibility and acceptability of HealthySMS, as well as its potential impact on EBI engagement.

Conclusions
Taken together, the results of this pilot study suggest that HealthySMS adjunct to adolescent CBT group depression services is feasible and acceptable, as evidenced by high rates of HealthySMS initiation and low rates of dropout, as well as meaningful themes uncovered from participants’ qualitative feedback. In addition, the findings provide evidence regarding iterative improvements to the HealthySMS system and research protocol, as well as potential mechanisms of change for enhanced EBI engagement and, ultimately, adolescent depression outcomes, which can be used in future effectiveness research.
Identification of Predictors of Mood Disorder Misdiagnosis and Subsequent Help-Seeking Behavior in Individuals With Depressive Symptoms: Gradient-Boosted Tree Machine Learning Approach
Authors: Benacek Jiri , Lawal Nimotalai , Ong Tommy , Tomasik Jakub , Martin-Key Nayra A , Funnell Erin L , Barton-Owen Giles , Olmert Tony , Cowell Dan , Bahn Sabine 
Published: January 2024

Background
Misdiagnosis and delayed help-seeking cause significant burden for individuals with mood disorders such as major depressive disorder and bipolar disorder. Misdiagnosis can lead to inappropriate treatment, while delayed help-seeking can result in more severe symptoms, functional impairment, and poor treatment response. Such challenges are common in individuals with major depressive disorder and bipolar disorder due to the overlap of symptoms with other mental and physical health conditions, as well as, stigma and insufficient understanding of these disorders.

Objective
In this study, we aimed to identify factors that may contribute to mood disorder misdiagnosis and delayed help-seeking.

Methods
Participants with current depressive symptoms were recruited online and data were collected using an extensive digital mental health questionnaire, with the World Health Organization World Mental Health Composite International Diagnostic Interview delivered via telephone. A series of predictive gradient-boosted tree algorithms were trained and validated to identify the most important predictors of misdiagnosis and subsequent help-seeking in misdiagnosed individuals.

Results
The analysis included data from 924 symptomatic individuals for predicting misdiagnosis and from a subset of 379 misdiagnosed participants who provided follow-up information when predicting help-seeking. Models achieved good predictive power, with area under the receiver operating characteristic curve of 0.75 and 0.71 for misdiagnosis and help-seeking, respectively. The most predictive features with respect to misdiagnosis were high severity of depressed mood, instability of self-image, the involvement of a psychiatrist in diagnosing depression, higher age at depression diagnosis, and reckless spending. Regarding help-seeking behavior, the strongest predictors included shorter time elapsed since last speaking to a general practitioner about mental health, sleep problems disrupting daily tasks, taking antidepressant medication, and being diagnosed with depression at younger ages.

Conclusions
This study provides a novel, machine learning–based approach to understand the interplay of factors that may contribute to the misdiagnosis and subsequent help-seeking in patients experiencing low mood. The present findings can inform the development of targeted interventions to improve early detection and appropriate treatment of individuals with mood disorders.
Web-Based Emotion Regulation Training for Sexual Health: Randomized Controlled Trial
Authors: Jobim Fischer Vinicius , Rossato Holz Maila , Billieux Joël , Andersson Gerhard , Vögele Claus 
Published: January 2024

Background
Effective emotional regulation (ER) skills are important for sexual function, as they impact emotional awareness and expression during sexual activity, and therefore, satisfaction and distress. Emotion regulation interventions may offer a promising approach to improve sexual health. Web-based emotion regulation may be a therapeutic strategy for men and women with sexual health concerns. Nevertheless, there is a scarcity of intervention trials investigating its effects in this context, much less using the internet.

Objective
This study aims to investigate the effects of a web-based emotion regulation training program for sexual function in both men and women.

Methods
The participants were recruited based on their self-reported sexual problems, which for men was defined by a score of <25 on the International Index Erectile Function (IIEF) and for women by a score of <26.55 on the Female Sexual Function Index (FSFI). The final sample included 60 participants who were randomized to either a web-based emotion regulation training for sexual function or to a waitlist control group. The treatment consisted of an 8-week web-based emotion regulation training for sexual function. The participants were assessed at baseline, post intervention, and the 3-month follow-up.

Results
Of the 60 participants included, only 6 completed all 3 assessment points (n=5, 20% in the treatment group and n=1, 5% in the waitlist control group) after receiving the intervention. At follow-up, there were no significant differences between groups in any measure. Among the intervention completers, large-to-moderate within-group effect sizes were observed between the assessment points on measures of emotion regulation, depression, lubrication, orgasm, thoughts of sexual failure, and abuse during sexual activity. The adherence rate was very low, limiting the generalizability of the findings.

Conclusions
Participants who completed the intervention showed improvements in both sexual function domains and emotion regulation. Nonetheless, due to a high dropout rate, this trial failed to collect sufficient data to allow for any conclusions to be drawn on treatment effects.

Trial Registration
ClinicalTrials.gov NCT04792177; https://clinicaltrials.gov/study/NCT04792177
PCAOB International Inspections and the Market Value of Cash Holdings
Authors: Liu Yiye , Yu Yangxin , Zhu Xindong 
Published: January 2024

ABSTRACT
This study examines whether and how Public Company Accounting Oversight Board (PCAOB) international inspections mitigate the market value discount in cash holdings. We find that shareholders value internal cash holdings more highly for the non-U.S.-listed clients of inspected auditors after the public disclosure of the auditors’ inspection reports. We show that the decreased agency frictions and the increased financial reporting credibility are potential mechanisms. Further, we find that the effect of PCAOB international inspections on the market value of cash holdings is stronger in countries with weaker legal institutions and less sound information environment. Since investors’ valuation of cash mirrors how they expect the cash to be used, our results suggest a unique role of PCAOB oversight in mitigating unresolved agency problems and safeguarding corporate resources, thereby lessening investors’ markdowns of cash assets. Our findings help identify the real economic impacts of PCAOB oversight in enhancing global stock market confidence.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: G34; M42; M48.
Pengaruh CAR, FDR dan NPF terhadap ROA Perbankan Syariah dengan PBH sebagai Variabel Moderating
Authors: Solika Siti Lina , Annisa Arna Asna 
Published: January 2024

This study aims to determine the effect of the Capital Adequacy Ratio (CAR), Financing to Debt Ratio (FDR) dan Non Performing Financial (NPF) to Profitabilityat Islamic Commercial Banks with Profit Sharing Financing as the Moderating variable. This research uses quantitative research using multiple linear regression analisys. The data in this study are secondary data, with the population of Islamic Commercial Banks in 2016-2020. The sampling technique used purposive sampling and obtained a sample of 10 Islamic Commercial Bank that met the criteria. The analysis tool uses the Eviews 9 application. Based on the f test, it is known that simultaneously the variable CAR, FDR, NPF and Profit Sharing Financing have an effect on Profitability. From the R2 test, it is known that the independent variable in this study affects the dependent variable by 99,6%. Based on the t-test, the result show that CAR has a significant positive effect on Profitability, FDR has no effect on Profitability, NPF has no significant positive effect on Profitability, Profit Sharing Financing has no effect on Profitability. From the result of the MRA test, it is known that PBH strengthens the effect of CAR on Profit Sharing Financing, PB weakens the influence of FDR on Profitability, while PBH is unable to moderate the effect of NPF Profit Sharing Financing.
Experimental Study of Polish Sausage Drying Kinetics and Contraction by Image Data Analysis
Authors: Jakubowska Blanka 
Published: January 2024

Abstract
The goal of this paper has been to add an experimental data set for drying a meat product and provide a comparison with well-established thin-layer drying models. This article presented experimental investigations on the convective drying of Polish sausage slices at a temperature of 40°C. Slices have been in the thickness of 3 to 8mm. Measurements of mass loss and size change were performed. The data have been presented in the form of standard drying kinetics. Additionally, the estimation of the diffusion coefficient according to the simplified graphical approach is made. Based on the best-fit approach the coefficients for typical semiempirical correlations for MR (moisture ratio) estimation have been calculated and presented.
The Use of Gaseous Ozone to Reduce the Microbial Load of Rhubarb (Rheum L.) Petioles as an Additive to Craft Wheat Beers
Authors: Zardzewiały Miłosz , Belcar Justyna , Gorzelany Józef 
Published: January 2024

Abstract
Rhubarb (Rheum rhaponticum L.) is a valuable source of active components responsible for laxative, antibacterial, diuretic, anti-inflammatory and anti-cancer properties. On the other hand, ozone being an allotropic form of oxygen, due to its potential is a powerful antimicrobial agent. Treatment of rhubarb petioles with gaseous ozone, especially at a concentration of 50 ppm, for 30 minutes had a positive result on the microbiological stability and quality of the finished material. Sensory evaluation of prepared beers enriched without ozonated and ozonated rhubarb pulp showed that wheat beer with the addition of ozonated (50 ppm) rhubarb pulp was characterized by a balanced aroma and taste. The physico-chemical analysis of wheat beers demonstrated that the increasing concentration of ozone had an impact on, among others, increased the degree of final real attenuation (by 21.97%), decreased pH (by 18.43%) and energy value (by 36.30%), but had a negative impact on the content of ethyl alcohol (by 17.32%) compared to the control beer. Among the analyzed beers enriched with rhubarb, the beer product with the addition of ozonated (50 ppm) rhubarb was the most microbiologically stable. The research shows that wheat beers enriched with fragmented rhubarb can be a new trend to expand the range of wheat beers, and the use of gaseous ozone, especially at a concentration of 50 ppm for 30 minutes, can be a trend to extend the microbiological stability of beers, especially craft beers.
Galium verum L. petroleum ether extract – antitumor potential on human melanoma cells
Authors: Semenescu Alexandra-Denisa , Moacă Elena-Alina , Chioibaş Raul , Iftode Andrada , Tchiakpe-Antal Diana-Simona , Vlase Laurian , Vlase Ana-Maria , Muntean Delia , Dehelean Cristina-Adriana 
Published: January 2024

Abstract
The important role of plants in the prevention and treatment of several ailments has been known since ancient times. Plants are a rich source of biocompounds with known therapeutic benefits. At the moment, natural products are a hope for certain diseases that modern medicine fails to cure. Cancerous pathologies were and still are a disease category in which the most effective treatment with the fewest adverse effects is constantly being sought. Malignant melanoma is the skin cancer that has produced the highest number of deaths and is intensively studied. Galium verum L. is a plant known for its traditional uses, for this reason, it is currently being studied in the therapy of several diseases, including cancer. Our study aimed to phytochemically characterize the petroleum ether extract and to evaluate its safety and antitumor potential on HaCaT and A375 cell lines, respectively. The FT-IR assay revealed that the GvPE extract comprises functional groups of lipophilic compounds and phenolic compounds, four compounds being qualitatively identified: rutin, isoquercitrin, quercetol, and chlorogenic acid through LC-MS analysis, in addition, a medium antioxidant capacity was observed. The results obtained on HaCaT showed that GvPE does not significantly reduce cell viability, and up to the tested doses it does not produce a relevant cytotoxic effect. In the case of skin cancer cells, the concentration of 55 μg/mL revealed a viability percentage of up to 55%, the cells becoming round and detaching from the plaque. Finally, the nuclear evaluation exhibited that the GvPE extract has an apoptotic-like effect, with the production of nuclear fragmentation and chromatin condensation.
Glycerolysis-Interesterification of Palm Olein and Coconut Oil Blend using Two High-Shear Continuous Stirred Tank Reactors
Authors: Ardani Aulia Safrina , Millati Ria , Yanti Rini , Rohana Nanda Legiasa Rabiul Tsani , Hidayat Chusnul 
Published: January 2024

Abstract
This study aimed to synthesize structured lipids containing high mono- and diacylglycerol by glycerolysisinteresterification of palm olein and coconut oil blend in two high-shear continuous stirred tank reactors in series. The result showed that various flow rates of 11 mL/min to 23 mL/min did not significantly increase mono- and diacylglycerol concentration, while at a flow rate of 26 mL/min only a low concentration of mono- and diacylglycerol was formed. However, a flow rate 20 mL/min and an agitating speed of 2000 rpm produced mono- and diacylglycerol concentration of 61.7% with the highest productivity of 2.1%/min and a triacylglycerol conversion of 64.6%. The slip melting point, melting point, hardness, emulsion capacity, and stability were 23.77 oC, 30 oC, 14.6 N, 65.15%, and 59.15%, respectively. The product’s solid fat content at 25 oC was lower than cocoa butter. The product contained β’ and β crystals, thus it can be applied as a cocoa butter substitute.