bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of loss to follow-up among tuberculosis patients in South Korea: whom should we focus on?
Authors: Kim Hyung Woo , Min Jinsoo , Ko Yousang , Oh Jee Youn , Jeong Yun-Jeong , Lee Eun Hye , Yang Bumhee , Koo Hyeon-Kyoung , Lee Sung-Soon , Park Jae Seuk , Park Kwang Joo , Chang Jung Hyun , Joh Joonsung , Lee Min Ki , Kim Ju Sang 
Published: October 2023

IntroductionIn South Korea, public-private mix (PPM) has been a key strategy in national tuberculosis (TB) control program. This study aimed to identify rate of loss to follow-up (LTFU) among TB patients in nationwide PPM institutions and their risk factors.MethodsA nationwide prospective observational study including drug susceptible TB patients diagnosed from the 1st day to the 10th day of every month between July 2018 and December 2020 in PPM institutions was designed. Multivariable survival models in which death and failure were designated as events with competing risk were used to investigate risk factors for LTFU.ResultsA total of 14,942 patients were included. Of them, 356 (2.4%) had an LTFU. Risk factors for LTFU were: underweight patients (adjusted hazard ratio (aHR): 1.47, 95% CI: 1.12–1.92), patients living alone (aHR: 1.43, 95% CI: 1.16–1.76), heavy drinkers (aHR: 1.67, 95% CI: 1.16–2.39), those with malignancy (aHR: 1.49, 95% CI: 1.07–2.05), foreigners (aHR: 5.96, 95% CI: 4.51–7.89), and those with previous TB history reported as an unfavorable outcome (aHR: 4.43, 95% CI: 2.77–7.08). Effect of age on LTFU was not significant. Brief interruption of anti-TB treatment (less than two months) in current session was associated with subsequent LTFU [adjusted odds ratio: 13.09 (10.29–16.66)].ConclusionIdentifying vulnerability of patients such as living alone, being heavy alcoholics, being foreigners or having previous TB history reported as an unfavorable outcome is required. Thorough case management for these vulnerable groups could be feasible with collaboration between public and private sectors.
Sanya climatic-treatment cohort profile: objectives, design, and baseline characteristics
Authors: Guan Haidao , Yang Guiyan , Gao Jiashi , Lin Xiaoya , Liu Chao , Ren Han , Chen Duyue , Zhou Lingyao , Hu Qian , Huang Yongzhen , Zhao Yumei , Tong Shilu , Lu Zhaohui , Liu Shijian , Wang Dan 
Published: October 2023

BackgroundThe prevalence of allergic diseases has increased globally, climate and environment also have important effects on respiratory or allergic diseases. However, population-based studies investigating the impact of tropical climates and environments on migratory-bird old people (MBOP) are lacking.Methods/DesignFor this prospective cohort study, we recruited 756 participants from the community in Sanya City, Hainan Province, China. In addition to the completed baseline survey, a follow-up survey will be conducted during the periods of October–December and March–April for the next 3 years of MBEPs from northern China who spend the winter in Sanya. We will continue to record the height, weight, and blood pressure of all participants, as well as lung function for those with asthma and chronic obstructive pulmonary disease (COPD). Venous blood at baseline and urine samples will be collected during follow-up.ResultsA total of 756 volunteers were recruited. Their average age is 66.1 years; 32.1% of them have high-school educations, while 37.3% have graduated from college or done undergraduate studies. The top five diseases in this cohort are allergic rhinitis (57.9%); eczema, urticaria, or dermatitis (35.6%); bronchitis and bronchiectasis (35.6%); asthma (14.7%); and emphysema (11.7%). Compared with their symptoms while at their summer places of residence, rates of remission reported by participants while living in Sanya were 80.4% for allergic rhinitis, 82.3% for bronchitis and emphysema, 85.2% for asthma, 96.0% for COPD (P &lt; 0.001).ConclusionsThe baseline survey has been completed. The preliminary findings support that a tropical climate may relieve the symptoms of allergic diseases in migratory-bird old people.
Effect of mineral-vitamin premix supplementation on behavioral, performance, hormonal, oxidative stress, and serum biochemical profiles on rutting male Camelus dromedarius in Egypt
Authors: Nasreldin Nani , EL-Shoukary Ramadan D. , Abdel-Raheem Ghada S. E. , Gharib Heba S. , Zigo František , Farkašová Zuzana , Rehan Ibrahim F. , Senosy Waleed 
Published: October 2023

IntroductionThe rutting period imposes a stressful condition on male camels, which results in elevated serum cortisol levels and alterations in their sexual behavior. Therefore, the current work was carried out to investigate the effect of mineral-vitamin premix supplementation on behavior, reproductive performance, hormones, serum oxidative stress profile, and other serum biochemical parameters of Camelus dromedarius during the breeding season.MethodsFourteen mature, fertile male Camelus dromedarius were divided into two groups, a control group (n = 7) and a mineral-vitamin premix group (n = 7). The present study lasted for 95 days during the rutting period (1st February to 5th May). Each camel in the premix group received a daily diet of 50 g of mineral-vitamin premix throughout the whole rutting period, during which the frequencies and durations of the following behaviors: maintenance, posture, aggressiveness, and sexual activity were collected every 20 min. At the end of the study, blood samples were collected.ResultsResults revealed that the premix group showed higher (P &lt; 0.05) maintenance (feeding and rumination), standing, and overall sexual desire-related behavior frequency, besides more times (P &lt; 0.001) for rumination, standing, walking, and lying while showing lower (P &lt; 0.001) frequencies of overall aggressive behaviors than the control group. The serum concentration of malondialdehyde, nitric oxide, cortisol, blood glucose, and urea evidenced a significant decrease in the premix group compared with the control one, while significantly elevated levels of reduced glutathione, testosterone, total antioxidant capacity, triiodothyronine, and thyroxin, total protein, albumin, globulin, calcium, phosphorus, potassium, and magnesium were recorded in the premix group in comparison with the control.ConclusionIt could be concluded that daily dietary supplementation of 50 g of mineral-vitamin premix to male camels during the breeding season is necessary to overcome the oxidative stress and serum cortisol concentration with a subsequent decrease in aggressive behavior and improvement to testosterone level in blood, body condition score and body weight gain.
Molecular Phenotyping and Mechanisms of Myocardial Fibrosis in Advanced Chronic Kidney Disease
Authors: Narayanan Gayatri , Halim Arvin , Hu Alvin , Avin Keith G. , Lu Tzongshi , Zehnder Daniel , Hato Takashi , Chen Neal X. , Moe Sharon M. , Lim Kenneth 
Published: October 2023

Key Points

Myocardial fibrosis in hearts from patients with CKD is characterized by increased trimeric tensile collagen type I and decreased elastic collagen type III compared with hearts from hypertensive or healthy donors, suggesting a unique fibrotic phenotype.Myocardial fibrosis in CKD is driven by alterations in extracellular matrix proteostasis, including dysregulation of metalloproteinases and cross-linking enzymes.CKD-associated mineral stressors uniquely induce a fibronectin-independent mechanism of fibrillogenesis characterized by formation of trimeric collagen compared with proinflammatory/fibrotic cytokines.

Background
Myocardial fibrosis is a major life-limiting problem in CKD. Despite this, the molecular phenotype and metabolism of collagen fibrillogenesis in fibrotic hearts of patients with advanced CKD have been largely unstudied.

Methods
We analyzed explanted human left ventricular (LV) heart tissues in a three-arm cross-sectional cohort study of deceased donor patients on hemodialysis (HD, n=18), hypertension with preserved renal function (HTN, n=8), and healthy controls (CON, n=17), ex vivo. RNA-seq and protein analysis was performed on human donor hearts and cardiac fibroblasts treated with mineral stressors (high phosphate and high calcium). Further mechanistic studies were performed using primary cardiac fibroblasts, in vitro treated with mineral stressors, proinflammatory and profibrotic cytokines.

Results
Of the 43 donor participants, there was no difference in age (P > 0.2), sex (P > 0.8), or body mass index (P > 0.1) between the groups. Hearts from the HD group had extensive fibrosis (P < 0.01). All LV tissues expressed only the trimeric form of collagen type I. HD hearts expressed increased collagen type I (P < 0.03), elevated collagen type I:III ratio (P < 0.05), and decreased MMP1 (P < 0.05) and MMP2 (P < 0.05). RNA-seq revealed no significant differential gene expression of extracellular matrix proteins of interest in HD hearts, but there was significant upregulation of LH2, periostin, α-SMA, and TGF-β1 gene expression in mineral stressor–treated cardiac fibroblasts. Both mineral stressors (P < 0.009) and cytokines (P < 0.03) increased collagen type I:III ratio. Mineral stressors induced trimeric collagen type I, but cytokine treatment induced only dimeric collagen type I in cardiac fibroblasts. Mineral stressors downregulated fibronectin (P < 0.03) and MMP2 zymogen (P < 0.01) but did not significantly affect expression of periostin, MMP1, or cross-linking enzymes. TGF-β upregulated fibronectin (P < 0.01) and periostin (P < 0.02) only.

Conclusions
Myocardial fibrosis in advanced CKD hearts is characterized by increased trimeric collagen type I and dysregulated collagen metabolism, and is differentially regulated by components of uremia.
Lasting Effects: What the Post Pandemic Return to In-person Teaching Tells Us About the State of e-Learning and its Future Trajectory
Authors: Charbonneau-Gowdy Paula , Frenzel Mónica 
Published: October 2023

An outpouring of studies on the forced move to distance learning during the COVID-19 pandemic has revealed deep concerns with teaching and learning online. Yet, now that most learning is returning to pre-pandemic environments, it seems naive to assume that teachers and learners in these settings, are, or will ever be, the same. A deeper understanding of the impact of those online experiences on teachers and learners before, during and immediately after the pandemic can provide insight into how to move forward in our educational systems, where technology is increasingly implicated. The conceptual framework of the study was based on the three key features of contemporary e-learning theory: learner-centred, community-based, constructivist-driven. We mapped this framework against course design, teaching approach and the use of technology to conceptualize the conditions that existed in returning to in-person teaching in a blended learning setting. This framework uncovers the developments, constraints, openness, and fears of a group of Higher Education (HE) EFL Chilean teachers in leading students into technology-enhanced, 21st century learning environments. A qualitative case study methodology was employed. Findings are based on written responses to an 8-item open questionnaire (n=32) and individual, oral-based (n=13) interviews along with field notes. Evidence of a significant advancement in digital literacy skills on the part of teachers, and indeed students was uncovered. Untypical in the Chilean educational context, a strong shift towards valuing more social constructivist teaching practices and an awareness of the importance of fostering relationship-building in learning ecologies, both in person and online, was also revealed. Changes attributed to both positive experiences online and reactions to negative ones, bode well for those long seeking a shift away from a traditional educational mindset that existed prior to the pandemic. At the same time, the findings that reveal hesitancy and in some cases fear of the rapidly encroaching new technologies, especially Artificial Intelligence (AI) tools, indicate that for some teachers the embrace of technology has its limits. We discuss both encouraging and more concerning results in terms of the insight they offer and their implications for further e-learning research and for educational stakeholders operating in increasingly technology-dependent learning spaces.
Impacts of COVID-19 on Higher Education in Developing Countries and the Strategy of Using ICTs for e-Teaching from Catholic University of Mozambique
Authors: Rhongo Domingos , Gerente Bianca 
Published: October 2023

COVID-19 has tested the organizational capacity of the education system in Mozambique, including the higher education level when it became mandatory to close all face-to-face teaching activities. To respond to this challenge and continue with the noble mission of teaching, the Catholic University of Mozambique implemented a hybrid model, specifically through digital platforms, even though it was aware of the various resource limitations on the part of teachers and students. This strategy would be determinant for a successful path to the purpose of "never stop teaching and learning." This paper attempts to answer questions that arose at introducing this new teaching model during the COVID-19: (i) What skills did teachers have to respond to ICT-mediated teaching? (ii) What strategies were used to circumvent the difficulties arising from COVID-19 for Teaching and Learning? (iii) What kind of skills, difficulty, and behaviour characterized the students to correspond to a 100% online teaching system? and (iv) What platforms and instruments were used to respond to this teaching model? The paper first seeks answers from exploratory interviews with teachers about the use of ICTs in teaching and learning and subsequently presents some challenges in three dimensions (institutions, teachers, and students) of which their consideration can lead to a path in the immersion of the technologization of teaching. In methodological terms, a qualitative approach was used, where interviews were conducted with a sample of teachers from this university who were part of the frontline of the process. The results show that for the case study it was possible, to teach and learn through Moodle platforms, Google Classroom, interacting through Zoom, Google Meet, and using Skype as a communication tool with students.
Revolutionizing agriculture from the skies: exploring the potential of spraying drones in precision farming
Authors: Castaldo João Henrique 
Published: October 2023

Este artigo analisa o modo como a agricultura está evoluindo e adotando novas tecnologias para atingir elevada eficiência. A agricultura de precisão é um fator-chave para esta evolução, e o uso de drones é identificado como uma das ferramentas que contribuem para a agricultura de precisão, particularmente em áreas onde o custo de mão de obra é alto, em áreas de difícil acesso e em pequenas fazendas. O artigo foca especificamente no uso dos drones de pulverização e seus benefícios, como menor custo e pulverização mais rápida do que os de pulverizadores tratorizados, acesso à culturas que são difíceis de se atingir, e habilidade de serem programados para voar em momentos específicos. O artigo também aborda as limitações dos drones de pulverização, tais como sua baixa capacidade, que pode levar ao uso de altas pressões de trabalho, e o alto custo dos equipamentos para os pequenos produtores. O maior desafio dos drones de pulverização são suas baterias, que precisam ser leves, mas fortes o suficiente para suprir a operação do drone. De modo geral, o uso dos drones na agricultura é promissor para o aumento de eficiência e precisão, mas ainda há detalhes que precisam ser discutidos, para que eles se tornem mais acessíveis e adotados pelos produtores.
ЕФЕКТИВНІСТЬ ОФШОРНИХ ВІТРОЕЛЕКТРОСТАНЦІЙ
Authors: Нечай I. В. 
Published: October 2023

Світова спільнота намагається відшукати більше екологічних способів виробництва електроенергії. Офшорні вітроелектростанції є одним з тих видів станцій, які можуть виробляти значну кількість електроенергії. Одна така станція
може забезпечувати прибережне місто незалежно від загальної мережі. В міру того, як збільшуватиметься віддаленість вітрових турбін від берега, зростатиме кількість виробленої енергії.
La complejidad en el campo educativo
Authors: Barrientos Reyes Vilda Nohemí 
Published: October 2023

PROBLEMA: Actualmente en los sistemas educativos de Guatemala, se habla de un nuevo paradigma educativo sobre la complejidad inmersa en el campo educativo, con la finalidad de realizar mejoras en los aprendizajes de los estudiantes del nivel superior desde los diferentes contextos y las diversas realidades que nos presenta un mundo industrializado, atrayente de nuevas formas de aprender a través de la tecnología de la información y comunicación, sobre todo de la investigación científica. Se plantea el problema de ¿Cómo incide la complejidad en el campo educativo? OBJETIVO: Reflexionar sobre la complejidad en el campo educativo. MÉTODO: el enfoque del estudio es descriptivo y hermenéutico. RESULTADOS: los docentes tienen en sus manos realizar cambios y mejoras de sus prácticas metodológicas con enfoque de la complejidad, que conduzcan a una formación de calidad con pensamientos reflexivos y propositivos en un mundo competitivo e interdisciplinar. REFLEXIONES INCONCLUSAS: el comportamiento del ser humano en el aprendizaje, manifiesta dificultades que inconscientemente aparecen al momento de desarrollar habilidades intelectuales y por ende la educación no debe enfocarse más en el error ni en la ilusión, cada mente del ser humano está exteriorizada en lo no real de su existencia.
Diversifikasi Produk Berbahan Dasar Ikan Patin Untuk Meningkatkan Pendapatan Masyarakat Di Desa Bincau Kecamatan Martapura Kabupaten Banjar
Authors: Lilimantik Emmy , Sari Nurma 
Published: October 2023

Striped catfish is one of the leading sectors in aquaculture in Banjar Regency, it is stated in the Decree of the Minister of Maritime Affairs and Fisheries of the Republic of Indonesia Number. KEP.32/MEN/2010 and the Decree of the Banjar Regency Number. 241 of 2008 about the Stipulation of Striped Catfish Cultivation Fisheries Areas. Until this time, striped catfish production is mostly sold in fresh form in traditional markets from South Kalimantan to Central Kalimantan and East Kalimantan. Whereas striped catfish can be processed into various varied and productive forms because it has a rich taste, colored meat with a chewy texture, highly nutritious and affordable prices. To increase the utilization of striped catfish, it is necessary to have processed products in order to increase the income of the surrounding community. The Community Partnership Program activity aims to transfer community technology through training in processing various foods made from striped catfish. The method consists of (a) counseling and (b) practical demonstration which aims to provide knowledge and skills to the target audience, which are the communities around the striped catfish minapolitan in Bincau Village, Martapura District, Banjar Regency. The continuance from the training results of this activity is to increase community skills in processing catfish-based products which leads to improvements in the household economic sector through economic growth and increasing incomes of the surrounding community.
Implementasi Screw Extruder Untuk Usaha Getuk Singkong di Kecamatan Tegaldlimo Kabupaten Banyuwangi
Authors: Nalandari Rezki 
Published: October 2023

Getuk merupakan jajanan tradisional berbahan dasar singkong yang masih banyak digemari masyarakat. Usaha mikro dan usaha kecil produksi getuk umumnya masih menggunakan proses produksi tradisional atau manual dan pemasaran dengan penjualan langsung. Kegiatan pengabdian masyarakat ini bertujuan untuk mengimplementasikan screw extruder dan packaging untuk kelompok usaha getuk singkong di Tegaldlimo Kabupaten Banyuwangi. Kelompok usaha ini memiliki permasalahan teknis berupa peralatan produksi dan permasalahan manajemen berupa kemasan produk dan pemasaran. Proses produksi memiliki kendala dalam pelumatan singkong kukus dan pencampuran karena proses manual membutuhkan waktu proses yang relatif lama. Selain itu, pengoperasian peralatan manual dengan tangan beresiko terhadap kelelahan, bahkan cidera. Penyerahan alat didampingi tim teknis terkait kelistrikan dan aspek mekanis. Implementasi screw extruder diprediksi dapat mengurangi waktu produksi sampai 50% dan meningkatkan kapasitas produksi harian sampai dua kali lipat. Pelaksanaan seluruh kegiatan diharapkan dapat meningkatkan omset harian mitra sampai dua kali lipat.

Kata kunci: getuk, singkong, screw extruder, kemasan
«Wiersz o sztuce aktorskiej» Ludwika Osińskiego w świetle teorii pedagogicznych
Authors: Buczek Katarzyna 
Published: October 2023

Wiosną 1803 roku periodyk Nowy Pamiętnik Warszawski opublikował "Wiersz o sztuce aktorskiej ofiarowany aktorce zaczynającej" napisany przez Ludwika Osińskiego. Poemat ten był dedykowany Rozalii Bogusławskiej, córce dyrektora Teatru Narodowego Wojciecha Bogusławskiego. Rozalia zadebiutowała na scenie rok wcześniej, a później wyszła za mąż za autora wiersza. Omawiany utwór nie jest, jak sugeruje tytuł, adresowany tylko do początkujących aktorów. Widać w nim gruntowną wiedzę z zakresu pedagogiki ogólnej, edukacji i dydaktyki, którą Ludwik Osiński dysponował dzięki swojemu wykształceniu i zawodowi. Uczył się w kolegium pijarskim, pracował jako guwerner i nauczyciel; wraz z Konstantym Wolskim prowadził też szkołę z internatem dla chłopców, znał więc dobrze teorie pedagogiczne Jana Amosa Komeńskiego, François Fénelona, Johna Locke'a i Jean-Jacques'a Rousseau. Znalazły one odbicie w omawianym wierszu, który odnosi się do kwestii szerszych niż tylko pedagogika zawodu aktora.
Wczesna dramaturgia Stefana Żeromskiego w świetle jego fascynacji teatrem
Authors: Sobieraj Tomasz 
Published: October 2023

Artykuł prezentuje kontekstową interpretację dwóch wczesnych dramatów Stefana Żeromskiego, Grzech i Dramatu akt pierwszy, niepublikowanych i niewystawianych za życia pisarza i odkrytych dopiero w 1945 i 1959 roku. Żeromski przez całe życie fascynował się teatrem, czego wyrazem może być na przykład jego nieukończony esej "Pochwała sztuki teatru" z 1924 roku lub odpowiedź na ankietę przygotowaną przez "Przegląd Warszawski" dotyczącą Teatru Narodowego w Warszawie, który wtedy ponownie otwierał swoje podwoje. Jego poglądy są bliskie ideom głoszonym przez twórcę narodowej sceny, Wojciecha Bogusławskiego, a także wszystkim formułowanym w XIX wieku poglądom, które podkreślały społeczną i patriotyczną misję polskiego teatru. Artystyczna wyobraźnia pisarza kształtowała się na podstawie konwencji teatru XIX wieku, opartego na iluzji scenicznej, zasadzie psychologicznej wiarygodności i wymaganiach naturalnego wyrazu aktorskiego. Głosząc pierwszeństwo deklamacji i słowa poetyckiego w teatrze, Żeromski opowiadał się za literackimi teoriami dramatu. Grzech i Dramatu akt pierwszy (który pozostał nieukończony) to dowód zdolności dramaturgicznych autora. W obu tekstach jego nowatorskie podejście do tematyki i problemów społecznych łączy się z konwencjami dramatu i teatru XIX wieku. Pierwsza inscenizacja Grzechu z nowym zakończeniem napisanym przez Leona Kruczkowskiego w 1950 roku stanowi interesujący epizod w historii polskiego życia teatralnego w połowie XX wieku, świadczący o ówczesnych ograniczeniach ideologicznych i politycznych.