bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endowing Polyetheretherketone with Anti‐Infection and Immunomodulatory Properties through Guanidination Carbon Dots Modification to Promote Osseointegration in Diabetes with MRSA Infection
Authors: Bai Xinxin , Zhang Xintian , Xiao Jiecheng , Lin Xingyu , Lin Rongjie , Zhang Rui , Deng Xiaoqin , Zhang Menghan , Wei Wenqin , Lan Bin , Weng Shaohuang , Chen Min 
Published: December 2023

AbstractMethicillin‐resistant Staphylococcus aureus (MRSA) infection and compromised immunity are the severe complications associated with implantation surgery in diabetes mellitus. Enhancing the antibacterial and immunomodulatory properties of implants represents an effective approach to improve the osseointegration of implant in diabetes mellitus. Herein, guanidination carbon dots (GCDs) with antibacterial and immunoregulatory functions are synthesized. The GCDs demonstrate killing effect on MRSA without detectable induced resistance. Additionally, they promote the polarization of macrophages from the M1 to M2 subtype, with the inhibiting pro‐inflammatory cytokines and promoting anti‐inflammatory factors. Correspondingly, GCDs are immobilized onto sulfonated polyether ether ketone (SP@GCDs) using a polyvinyl butyraldehyde (PVB) coating layer through soaking‐drying technique. SP@GCDs maintain stable antibacterial efficacy against MRSA for six consecutive days and retain the immunomodulatory function, while also possessing the long‐term storage stability and biocompatibility of more than 6 months. Moreover, SP@GCDs significantly promote the proliferation and mineralization of osteoblasts. SP@GCDs facilitate osteogenesis through immunoregulatory. Additionally, SP@GCDs exert stable antibacterial and immune regulatory functions in implantation site of a diabetes rat, effectively promoting implant osseointegration regardless of the MRSA infection. These findings provide valuable insights into implant modification through designing nanomaterials with multifunction for enhancing osseointegration of diabetes mellitus, suggesting the promising clinical application prospects.
Magnetic Chitosan Bionanocomposite Films as a Versatile Platform for Biomedical Hyperthermia
Authors: Barra Ana , Wychowaniec Jacek K. , Winning Danielle , Cruz Maria Margarida , Ferreira Liliana P. , Rodriguez Brian J. , Oliveira Helena , Ruiz‐Hitzky Eduardo , Nunes Cláudia , Brougham Dermot F. , Ferreira Paula 
Published: December 2023

AbstractResponsive magnetic nanomaterials offer significant advantages for innovative therapies, for instance, in cancer treatments that exploit on‐demand delivery on alternating magnetic field (AMF) stimulus. In this work, biocompatible magnetic bionanocomposite films are fabricated from chitosan by film casting with incorporation of magnetite nanoparticles (MNPs) produced by facile one pot synthesis. The influence of synthesis conditions and MNP concentration on the films’ heating efficiency and heat dissipation are evaluated through spatio‐temporal mapping of the surface temperature changes by video‐thermography. The cast films have a thickness below 100 µm, and upon exposure to AMF (663 kHz, 12.8 kA m−1), induce exceptionally strong heating, reaching a maximum temperature increase of 82 °C within 270 s irradiation. Further, it is demonstrated that the films can serve as substrates that supply heat for multiple hyperthermia scenarios, including: i) non‐contact automated heating of cell culture medium, ii) heating of gelatine‐based hydrogels of different shapes, and iii) killing of cancerous melanoma cells. The films are versatile components for non‐contact stimulus with translational potential in multiple biomedical applications.
Multicrystalline Informatics Applied to Multicrystalline Silicon for Unraveling the Microscopic Root Cause of Dislocation Generation
Authors: Yamakoshi Kenta , Ohno Yutaka , Kutsukake Kentaro , Kojima Takuto , Yokoi Tatsuya , Yoshida Hideto , Tanaka Hiroyuki , Liu Xin , Kudo Hiroaki , Usami Noritaka 
Published: December 2023

AbstractA comprehensive analysis of optical and photoluminescence images obtained from practical multicrystalline silicon wafers is conducted, utilizing various machine learning models for dislocation cluster region extraction, grain segmentation, and crystal orientation prediction. As a result, a realistic 3D model that includes the generation point of dislocation clusters is built. Finite element stress analysis on the 3D model coupled with crystal growth simulation reveals inhomogeneous and complex stress distribution and that dislocation clusters are frequently formed along the slip plane with the highest shear stress among twelve equivalents, concentrated along bending grain boundaries (GBs). Multiscale analysis of the extracted GBs near the generation point of dislocation clusters combined with ab initio calculations has shown that the dislocation generation due to the concentration of shear stress is caused by the nanofacet formation associated with GB bending. This mechanism cannot be captured by the Haasen‐Alexander‐Sumino model. Thus, this research method reveals the existence of a dislocation generation mechanism unique to the multicrystalline structure. Multicrystalline informatics linking experimental, theoretical, computational, and data science on multicrystalline materials at multiple scales is expected to contribute to the advancement of materials science by unraveling complex phenomena in various multicrystalline materials.
Integrated Optical Sensing and Communication (IOSAC) System Based on Hybrid‐Waveguide Structures
Authors: Ou Xiangpeng , Qiu Ying , Luo Ming , Li Junjie , He Xiaobin , Gao Jianfeng , Sun Fujun , Zhang Peng , Yang Gang , Du Anyan , Li Bin , Liu Zichen , Li Zhihua , Xie Ling , Xiao Xi , Luo Jun , Wang Wenwu , Tao Jin , Yang Yan 
Published: December 2023

AbstractAdvanced silicon photonic technologies enable integrated optical sensing and communication (IOSAC) in real time for the emerging application requirements of simultaneous sensing and communication for next‐generation networks. Herein, an IOSAC system is proposed and demonstrated on the silicon nitride (Si3N4) photonics platform. The IOSAC devices leveraging microring resonators excel in real‐time monitoring of analyte fluctuations and efficiently transmit this data to the terminal, positioning them as viable alternatives to bulk optics in applications that demand both high precision and speed. By directly integrating Si3N4 ring resonators with optical communication networks, simultaneous sensing and optical communication are demonstrated by an optical signal transmission experimental system using especially filtering amplified spontaneous emission spectra. The refractive index (RI) sensing ring with a sensitivity of 172 nm RIU−1, a figure of merit (FOM) of 1220, and a detection limit (DL) of 8.2 × 10−6 RIU is demonstrated. Simultaneously, the 1.25 Gbps optical on‐off‐keying (OOK) signal is transmitted at the concentration of different NaCl solutions, indicating the bit‐error‐ratio (BER) decreases with the increase in concentration. The novel IOSAC technology shows the potential to realize high‐performance simultaneous biosensing and communication in real time and further accelerate the development of IoT and 6G networks.
Photoacid Generators for Biomedical Applications
Authors: Sun Tianzhen , Kang Lin , Zhao Hongyou , Zhao Yuxia , Gu Ying 
Published: December 2023

AbstractPhotoacid generators (PAGs) are compounds capable of producing hydrogen protons (H+) upon irradiation, including irreversible and reversible PAGs, which have been widely studied in photoinduced polymerization and degradation for a long time. In recent years, the applications of PAGs in the biomedical field have attracted more attention due to their promising clinical value. So, an increasing number of novel PAGs have been reported. In this review, the recent progresses of PAGs for biomedical applications is systematically summarized, including tumor treatment, antibacterial treatment, regulation of protein folding and unfolding, control of drug release and so on. Furthermore, a concept of water‐dependent reversible photoacid (W‐RPA) and its antitumor effect are highlighted. Eventually, the challenges of PAGs for clinical applications are discussed.
Engineering Versatile Nanomedicines for Ultrasonic Tumor Immunotherapy
Authors: Liang Jing , Qiao Xiaohui , Qiu Luping , Xu Huning , Xiang Huijing , Ding Hong , Chen Yu 
Published: December 2023

AbstractDue to the specific advantages of ultrasound (US) in therapeutic disease treatments, the unique therapeutic US technology has emerged. In addition to featuring a low‐invasive targeted cancer‐cell killing effect, the therapeutic US technology has been demonstrated to modulate the tumor immune landscape, amplify the therapeutic effect of other antitumor therapies, and induce immunosensitization of tumors to immunotherapy, shedding new light on the cancer treatment. Tremendous advances in nanotechnology are also expected to bring unprecedented benefits to enhancing the antitumor efficiency and immunological effects of therapeutic US, as well as therapeutic US‐derived bimodal and multimodal synergistic therapies. This comprehensive review summarizes the immunological effects induced by different therapeutic US technologies, including ultrasound‐mediated micro‐/nanobubble destruction (UTMD/UTND), sonodynamic therapy (SDT), and focused ultrasound (FUS), as well as the main underlying mechanisms involved. It is also discussed that the recent research progress of engineering intelligent nanoplatform in improving the antitumor efficiency of therapeutic US technologies. Finally, focusing on clinical translation, the key issues and challenges currently faced are summarized, and the prospects for promoting the clinical translation of these emerging nanomaterials and ultrasonic immunotherapy in the future are proposed.
Fast Energy Storage of SnS2 Anode Nanoconfined in Hollow Porous Carbon Nanofibers for Lithium‐Ion Batteries
Authors: Liang Fanghua , Dong Huilong , Dai Jiamu , He Honggang , Zhang Wei , Chen Shi , Lv Dong , Liu Hui , Kim Ick Soo , Lai Yuekun , Tang Yuxin , Ge Mingzheng 
Published: December 2023

AbstractThe development of conversion‐typed anodes with ultrafast charging and large energy storage is quite challenging due to the sluggish ions/electrons transfer kinetics in bulk materials and fracture of the active materials. Herein, the design of porous carbon nanofibers/SnS2 composite (SnS2@N‐HPCNFs) for high‐rate energy storage, where the ultrathin SnS2 nanosheets are nanoconfined in N‐doped carbon nanofibers with tunable void spaces, is reported. The highly interconnected carbon nanofibers in three‐dimensional (3D) architecture provide a fast electron transfer pathway and alleviate the volume expansion of SnS2, while their hierarchical porous structure facilitates rapid ion diffusion. Specifically, the anode delivers a remarkable specific capacity of 1935.50 mAh g−1 at 0.1 C and excellent rate capability up to 30 C with a specific capacity of 289.60 mAh g−1. Meanwhile, at a high rate of 20 C, the electrode displays a high capacity retention of 84% after 3000 cycles and a long cycle life of 10 000 cycles. This work provides a deep insight into the construction of electrodes with high ionic/electronic conductivity for fast‐charging energy storage devices.
Comparison of total daily energy expenditure with dietary reference intakes values in a sample of urban, relatively active Brazilian adults: A doubly labeled water study
Authors: Bossan Francine Moreira , dos Anjos Luiz Antonio , Wahrlich Vivian , Ferriolli Eduardo , Pfrimer Karina 
Published: December 2023

AbstractObjectiveThis report aimed to describe the results of total daily energy expenditure (TDEE) assessed by doubly labeled water (DLWTDEE) and the adequacy of the dietary reference intakes (DRI) equations to estimate energy requirements (DRIER).MethodsA cross‐sectional and observational study in a convenience sample of 40 healthy Brazilian adults (≥20 years; 21 women) living in a tropical urban region. Basal metabolic rate (BMR) was measured by indirect calorimetry, DLWTDEE was compared with DRIER using individual calculated physical activity level (PAL = DLWTDEE/BMR) in its estimation.ResultsBMR (5043 ± 548 kJ/day in women and 6213 ± 656 kJ/day in men), DLWTDEE (8372 ± 1324 kJ/day and 11 453 ± 1834 kJ/day), and PAL (1.66 ± 0.17 and 1.85 ± 0.30, respectively) were significantly higher in men. The DRIER significantly overestimated DLWTDEE by 13.7 ± 8.3% and 12.7 ± 10.7% in women and men, respectively.ConclusionIn the present sample of relatively active urban Brazilian subjects, the DRIER yielded inaccurate estimation of DLWTDEE. More data from low‐ and moderate‐income countries are necessary to develop accurate estimates of TDEE.
An adult patient with Tatton–Brown–Rahman syndrome caused by a novel DNMT3A variant and axonal polyneuropathy
Authors: AlSabah Al‐Alya , Alsalmi Mohammed , Massie Rami , Bilodeau Marie‐Claude , Campeau Philippe M. , McGraw Serge , D'Agostino Maria Daniela 
Published: December 2023

AbstractTatton–Brown–Rahman syndrome (TBRS) is a rare autosomal dominant overgrowth syndrome first reported in 2014 and caused by pathogenic variants in the DNA methyltransferase 3A (DNMT3A) gene. All individuals reported to date share a phenotype of somatic overgrowth, dysmorphic features, and intellectual disability. Peripheral neuropathy was not described in these cases. We report an adult patient with TBRS caused by a novel pathogenic DNMT3A variant (NM_175629.2: c.2036G>A, p.(Arg688His)) harboring an axonal length‐dependent sensory‐motor polyneuropathy. Extensive laboratory and molecular genetic work‐up failed to identify alternative causes for this patient's neuropathy. We propose that axonal neuropathy may be a novel, age‐dependent phenotypic feature in adults with TBRS and suggest that this syndrome should be considered in the differential diagnosis of patients with overgrowth, cognitive and psychiatric difficulties, and peripheral neuropathy.
Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population‐based study
Authors: Ren Yifei , Li Yuanjing , Tian Na , Liu Rui , Dong Yi , Hou Tingting , Liu Cuicui , Han Xiaolei , Han Xiaodong , Wang Lidan , Vetrano Davide Liborio , Ngandu Tiia , Marengoni Alessandra , Kivipelto Miia , Wang Yongxiang , Cong Lin , Du Yifeng , Qiu Chengxuan 
Published: December 2023

AbstractINTRODUCTIONTo examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)‐related plasma biomarkers among older adults.METHODSThis population‐based study included 5432 participants (age ≥60 years); of these, plasma amyloid beta (Aβ), total tau, and neurofilament light chain (NfL) were measured in a subsample (n = 1412). We used hierarchical clustering to generate five multimorbidity clusters from 23 chronic diseases. We diagnosed dementia and MCI following international criteria. Data were analyzed using logistic and linear regression models.RESULTSThe number of chronic diseases was associated with dementia (multivariable‐adjusted odds ratio = 1.22; 95% confidence interval [CI] = 1.11 to 1.33), AD (1.13; 1.01 to 1.26), vascular dementia (VaD) (1.44; 1.25 to 1.64), and non‐amnestic MCI (1.25; 1.13 to 1.37). Metabolic cluster was associated with VaD and non‐amnestic MCI, whereas degenerative ocular cluster was associated with AD (p < 0.05). The number of chronic diseases was associated with increased plasma Aβ and NfL (p < 0.05).DISCUSSIONMultimorbidity burden and clusters are differentially associated with subtypes of dementia and MCI and AD‐related plasma biomarkers in older adults.Highlights
We used hierarchical clustering to generate five clusters of multimorbidity.
The presence and load of multimorbidity were associated with dementia and mild cognitive impairment.
Multimorbidity clusters were differentially associated with subtypes of dementia and Alzheimer's disease plasma biomarkers.
Prospecting Quantum Correlations and Examining Teleportation Fidelity in a Pair of Coupled Double Quantum Dots System
Authors: Ait Chlih Anas , Rahman Atta ur , Habiballah Nabil 
Published: December 2023

AbstractThe topic of improving the ability of quantum systems to retain non‐local features and enhance the efficiency of quantum protocols continues. This study delves into the thermal investigation of quantum correlations and teleportation fidelity of a two‐qubit teleported state using excess electrons in a coupled double quantum dots system as a quantum channel. The study employs three reliable quantum quantifiers to prospect the resourcefulness and non‐classicality of the system. The findings suggest that preserving quantum correlations and optimizing teleportation fidelity require minimizing tunneling coupling and maximizing Coulomb interaction. The study has significant implications for quantum physics and its practical applications in quantum information processing.
Silk nanofibrous scaffolds assembled by natural polysaccharide konjac glucomannan
Authors: Xiao Jiahui , Ji Yueyang , Gao Zixin , Dai Yunfeng , Li Xiufang , Feng Yanfei , You Renchuan 
Published: December 2023

AbstractNatural silk fibroin nanofibers (SNF) have recently attracted great attention in the field of biomaterials due to their excellent biocompatibility, outstanding mechanical properties, and biomimetic nanostructures. However, the poor structural stability of SNF assembly in aqueous conditions remains a major obstacle to their biomedical application. In this work, SNF scaffolds with extracellular matrix‐mimicking architecture and tunable properties were developed by using a small amount of konjac glucomannan (KGM) as a physical adhesive. Fourier transform infrared spectroscopy (FTIR) results revealed that KGM facilitated the formation of hydrogen bond networks between SNF as well as nanofibers/polysaccharide molecules, thereby reinforcing the interconnectivity between SNF. The water stability test showed that SNF scaffolds exhibited good structural stability in water when the mass ratio of KGM/SNF reached 2.5/100. Raising KGM content significantly enhanced the compression strength, modulus, and swelling ratio of the porous scaffold. Whereas, the nanofibrous morphology and porosity of the scaffolds were significantly sacrificed as KGM content exceeded 10% as evidenced by scanning electron microscopy (SEM) results. In vitro, cytocompatibility results also demonstrated the excellent biocompatibility of the biomimetic nanofibrous scaffolds, and the high porosity significantly enhanced cell viability. These results suggest that KGM‐reinforced SNF scaffolds may serve as promising candidates for biomaterial applications.
Comparative analysis of specimen geometries in material extrusion 3D printing: Implications for mechanical property evaluation
Authors: Neivock Matheus P. , Gomide Caio S. , Nogueira Vinícius G. , Caires Anderson R. L. , Oliveira Samuel L. 
Published: December 2023

AbstractThis study investigated the influence of specimen geometry on the mechanical properties of 3D‐printed parts by material extrusion (MEX). Four widely used technical standards were evaluated (ASTM D638, ASTM D3039/D3039M‐14, ISO 527/2, and ISO 37), and all possible geometries were tested. The specimens were subjected to uniaxial tensile loading using a universal testing machine to obtain the mechanical properties of ultimate tensile strength, yield strength, and Young modulus. Mean, , and values, as well as (number of specimens tested to reach at least 10 valid data) are geometry‐dependent. A critical analysis of these data allowed proposing the standard evaluation index () of the specimen geometry (standard) based on data variance and test efficiency to achieve valid data. The results indicate that ASTM D638 performed better than any other standard. For investigations involving the mechanical properties of tensile strength Types I and II (ASTM D638) are the most recommended specimens geometry (standard) for 3D MEX printing because it combines the lowest with the minimum . By following it, researchers and material suppliers can ensure accurate and reliable assessments of the mechanical properties of 3D‐printed parts, contributing to increased safety, reliability, and quality in additive manufacturing. Notes: MEX – Material Extrusion, ASTM – American Society for Testing and Materials, ISO – International Organization for Standardization, SD – Standard Deviation, CV – Coefficient of Variation, – Number of specimens tested to reach at least 10 valid data, – Standard Evaluation Index.
The Melbourne Study of Psychoanalytic Psychotherapy low‐cost clinic I: Implementation, mental health and life functioning gains
Authors: Dean Suzanne , Tonge Bruce , Beaufoy Jeanette , Godfrey Celia , Grady Jacqueline , Pullen Jill , Smale Sarina , Hill Christine , Ivey Gavin , Taffe John 
Published: December 2023

AbstractThe Melbourne Study of Psychoanalytic Psychotherapy examined the implementation, lived experience, and perceived therapeutic gains of psychoanalytic psychotherapy in a low‐cost, private‐sector community clinic. A first in Australia, this 8‐year demonstration project allowed naturalistic study of the impact and process of intensive, long‐term, time‐limited psychoanalytic psychotherapy delivered to self‐referred adults by clinicians with a common theoretical frame of practice. Presented in three papers, the research employed the RE‐AIM planning and evaluation framework, using complementary quantitative and qualitative methods, to study the psychotherapy service in terms of Reach, Effectiveness, Adoption, Implementation and Maintenance. This first paper reports the Reach of the program to be 67% for those presenting for assessment for psychoanalytic psychotherapy, with Adoption of the full 2‐year treatment program being 60%. Improvements in mental health and life functioning provided quantitative evidence of Effectiveness for those completing the 2‐year treatment program, with Maintenance at 8‐month follow‐up. Patient age, gender and personality characteristics did not modify these improvements. In‐depth qualitative exploration of patient and psychotherapist perspectives regarding the psychotherapy is reported in the second paper highlighting expectations, experience and benefits of the psychotherapy. The third companion paper presents the qualitative findings concerning factors experienced as facilitating or challenging therapeutic progress. Each of the three related papers amplifies understandings of how low‐cost, long‐term but time‐limited psychoanalytic psychotherapy can be implemented in the community with adults otherwise unable to afford such treatment, and discusses lessons learned.