bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exceptional capture of methane at low pressure by an iron‐based metal‐organic framework
Authors: Ma Yujie , Li Cheng , Guo Lixia , Lu Wanpeng , Cheng Yongqiang , Han Xue , Li Jiangnan , Crawshaw Danielle , He Meng , Shan Lutong , Lee Daniel , da Silva Ivan , Manuel Pascal , Ramirez‐Cuesta Anibal J. , Schröder Martin , Yang Sihai 
Published: December 2023

AbstractThe selective capture of methane (CH4) at low concentrations and its separation from N2 are extremely challenging owing to the weak host‐guest interactions between CH4 molecules and any sorbent material. Here, we report the exceptional adsorption of CH4 at low pressure and the efficient separation of CH4/N2 by MFM‐300(Fe). MFM‐300(Fe) shows a very high uptake for CH4 of 0.85 mmol g−1 at 1 mbar and 298 K and a record CH4/N2 selectivity of 45 for porous solids, representing a new benchmark for CH4 capture and CH4/N2 separation. The excellent separation of CH4/N2 by MFM‐300(Fe) has been confirmed by dynamic breakthrough experiments. In situ neutron powder diffraction, and solid‐state nuclear magnetic resonance and diffuse reflectance infrared Fourier transform spectroscopies, coupled with modelling, reveal a unique and strong binding of CH4 molecules involving Fe−OH⋯CH4 and C⋯phenyl ring interactions within the pores of MFM‐300(Fe), thus promoting the exceptional adsorption of CH4 at low pressure.
Abandonment issues: A hazard analysis of high‐performance work practices
Authors: Rankin Scott B. 
Published: December 2023

AbstractThis study examines usage of high‐performance work practices (HPWPs) over time using a unique longitudinal survey of Canadian organizations. Human resource management (HRM) studies tell us HPWPs require long‐term commitment but rarely measure it. Using event history analysis this study finds high rates of HPWP abandonment. The study also examines organizational supports for high‐performance work system (HPWS). A Cox regression analysis finds rates of abandonment are reduced when HPWPs are accompanied by aligned business strategies and HR professional support. The results inform process research on HRM strategies and raise troubling questions for findings in studies that fail to measure duration. For managers, the findings highlight the importance of ensuring strategic alignment with and organizational support for HPWPs if they are to endure.
Treatment‐related cardiovascular events in patients with non–small cell lung cancer: Evidence from real‐world data with a competing risks approach
Authors: Tran Thi‐Ngoc , Lee Sanghee , Kim Hak Jin , Lee Youngjoo , Tu Thao Minh , Choi Jin‐Ho , Song Jae Won , Cho Hyunsoon 
Published: December 2023

AbstractBackgroundUnderstanding cancer treatment–related cardiovascular (CV) events is important for cancer care; however, comprehensive evaluation of CV events in patients with lung cancer is limited. This study aimed to assess the cumulative incidence and associated risks of various CV event types in patients with non–small cell lung cancer (NSCLC).MethodsA total of 7868 individuals aged 40 years and older, recently diagnosed with NSCLC (2007–2018), were assessed with data obtained from the National Cancer Center, Korea. This study included nine types of CV events. A 2‐year cumulative incidence function (CIF) of CV events was estimated, with death as a competing event. The associated risks were assessed by subdistribution hazard ratio (sHR) in the Fine–Gray competing risks model.ResultsCV events were observed in 7.8% of patients with NSCLC, with the most frequently observed types being atrial fibrillation and flutter (AF) (2.7%), venous thromboembolic disease (2.0%), and cerebrovascular disease (CeVD) (1.5%). Overall, all CV events were highest in the group treated with systemic therapy (CIF, 10.6%; 95% confidence interval [CI], 9.5%–11.8%), followed by those treated with surgery (CIF, 10.0%; 95% CI, 8.6%–11.6%); the incidence of AF (CIF, 5.7%; 95% CI, 4.6%–7.0%) was highest in patients treated with surgery. Individuals treated with systemic therapy were found to exhibit a higher CeVD risk than those treated with surgery (sHR, 4.12; 95% CI, 1.66–10.23). Among the patients who underwent surgery, those with lobectomy and pneumonectomy had a higher AF risk (vs. wedge resection/segmentectomy; sHR, 7.79; 95% CI, 1.87–32.42; sHR, 8.10; 95% CI, 1.60–40.89).ConclusionsThese findings revealed treatment‐related CV event risks in patients with NSCLC, which suggests that the risk of AF in surgery and CeVD in systemic therapy should be paid more attention to achieve a better prognosis and improve cancer survivorship outcomes.Plain Language Summary

Atrial fibrillation and flutter (AF) is the most common cardiovascular event, particularly at a high risk in patients with non–small cell lung cancer (NSCLC) undergoing surgery.
Patients receiving surgery with poor performance status, diagnosed with regional stage, and undergoing lobectomy or pneumonectomy are at a high risk of AF.
Systemic/radiotherapy is associated with cerebrovascular and ischemic heart disease in patients with NSCLC.
Does a prior diagnosis of infectious disease confer an increased risk of latent autoimmune diabetes in adults?
Authors: Edstorp Jessica , Rossides Marios , Ahlqvist Emma , Rasouli Bahareh , Tuomi Tiinamaija , Carlsson Sofia 
Published: December 2023

AbstractAimsInfections are proposed risk factors for type 1 diabetes in children. We examined whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults (LADA).Materials and methodsWe used data from a population‐based Swedish case‐control study with incident cases of LADA (n = 597) and matched controls (n = 2386). The history of infectious disease was ascertained through national and regional patient registers. We estimated adjusted odds ratios (OR) with 95% confidence intervals for ≥1 respiratory (any/upper/lower), gastrointestinal, herpetic, other or any infectious disease episode, or separately, for 1 and ≥2 infectious disease episodes, within 0–1, 1–3, 3–5 and 5–10 years before LADA diagnosis/matching. Stratified analyses were performed on the basis of HLA risk genotypes and Glutamic acid decarboxylase antibodies (GADA) levels.ResultsIndividuals who developed LADA did not have a higher prevalence of infectious disease 1–10 years before diabetes diagnosis. For example, OR was estimated at 0.87 (0.66, 1.14) for any versus no respiratory infectious disease within 1–3 years. Similar results were seen for LADA with high‐risk HLA genotypes (OR 0.95 [0.64, 1.42]) or high GADA levels (OR 1.10 [0.79, 1.55]), ≥2 episodes (OR 0.89 [0.56, 1.40]), and in infections treated using antibiotics (OR 1.03 [0.73, 1.45]). The only significant association was observed with lower respiratory disease the year preceding LADA diagnosis (OR 1.67 [1.06, 2.64]).ConclusionsOur findings do not support the idea that exposure to infections increases the risk of LADA. A higher prevalence of respiratory infection in the year before LADA diagnosis could reflect increased susceptibility to infections due to hyperglycemia.
Picturing oneself over time: a multi‐modal interpretative phenomenological analysis of pain management trajectories
Authors: Nizza I. E. , Smith J. A. , Kirkham J. A. 
Published: December 2023

AbstractBackgroundChronic pain (CP) can be a disabling condition with impacts that affect the sense of identity of those who live with it. This article idiographically describes the longitudinal evolution of the sense of self of participants following their referral to a pain management service and participation in a pain management programme (PMP).MethodsParticipants were interviewed three times: before they attended a PMP, and 1 and 6 months after the PMP. Data included the drawings of themselves that participants created at each interview and the transcripts of the interviews guided by the drawings, analysed longitudinally using interpretative phenomenological analysis.ResultsThis paper describes in detail the cases of four participants: two who experienced a positive albeit troubled trajectory following their PMP and two who did not experience any positive change. The results provide a nuanced account of how the impacts of CP on identity can evolve, with different people engaging with different aspects of a PMP and some people not engaging at all, and how pain self‐management strategies enable those that do engage to cope in times of difficulty.ConclusionsParticipant responses to PMP participation are idiosyncratic and interviews with drawings of self analysed longitudinally can help illustrate processes of change.SignificanceNot enough is understood about why some people get limited benefits from pain services. This idiographic longitudinal study illustrates how the impact of CP on identity can evolve when people are introduced to pain self‐management, with some embracing change and others resisting it. For clinicians, this study describes four detailed CP individual paths, showing the interaction between contextual and idiosyncratic aspects. This is also the first study to use multiple drawings of self to explore the impacts of illness on identity longitudinally. In a person‐centred approach to treatment, the drawings of self could also be adopted as a tool in clinician‐patient conversations to gain a deeper understanding of the impacts of living with CP.
A two‐component model of hair cortisol concentration in fibromyalgia: Independent effects of pain chronicity and severity
Authors: Reyes del Paso G. A. , Garcia‐Hernandez A. , Contreras‐Merino A. M. , Galvez‐Sánchez C. M. , de la Coba P. , Montoro C. I. , Davydov D. M. 
Published: December 2023

AbstractBackgroundFibromyalgia (FM) is a chronic pain disorder of unknown aetiopathogenesis, in which the role of activity of the hypothalamic–pituitary–adrenal (HPA) axis is not clearly established.MethodsThis study analysed the modulatory effects of disease chronicity and severity on cortisol levels. Hair cortisol concentrations (HCC) and clinical evaluation data (pain severity, impact of FM on daily activities, depression, anxiety, fatigue and insomnia) were collected from 47 female patients with FM and 36 healthy women (HW).ResultsThe results showed that disease chronicity, with a negative effect, and symptom severity, with a positive effect, were independent predictors of HCC. Patients with a shorter disease duration had higher HCC than patients with a longer disease duration and healthy participants. Furthermore, patients with greater symptom severity had higher HCC than those patients with lower clinical severity and healthy participants. While disease chronicity in FM was associated with a decrease in HCC, clinical severity increased HCC.ConclusionsThese results support the existence of a dysfunction in the regulation of the HPA axis in FM and its possible contribution to chronic pain development.SignificanceThis is the first study to assess hair cortisol concentrations in a specific sample of patients with fibromyalgia (FM). This method is especially useful for the assessment of long‐term regular cortisol excretion. Results showed a two‐component model for explaining cortisol levels: disease chronicity, with a negative effect, and symptom severity, with a positive effect. This suggests that severe pain/stress evokes higher cortisol levels at earlier stages of FM, while in the longer term a decrease in cortisol levels was observed.
EPPTA: Efficient partially observable reinforcement learning agent for penetration testing applications
Authors: Li Zegang , Zhang Qian , Yang Guangwen 
Published: December 2023

AbstractIn recent years, penetration testing (pen‐testing) has emerged as a crucial process for evaluating the security level of network infrastructures by simulating real‐world cyber‐attacks. Automating pen‐testing through reinforcement learning (RL) facilitates more frequent assessments, minimizes human effort, and enhances scalability. However, real‐world pen‐testing tasks often involve incomplete knowledge of the target network system. Effectively managing the intrinsic uncertainties via partially observable Markov decision processes (POMDPs) constitutes a persistent challenge within the realm of pen‐testing. Furthermore, RL agents are compelled to formulate intricate strategies to contend with the challenges posed by partially observable environments, thereby engendering augmented computational and temporal expenditures. To address these issues, this study introduces EPPTA (efficient POMDP‐driven penetration testing agent), an agent built on an asynchronous RL framework, designed for conducting pen‐testing tasks within partially observable environments. We incorporate an implicit belief module in EPPTA, grounded on the belief update formula of the traditional POMDP model, which represents the agent's probabilistic estimation of the current environment state. Furthermore, by integrating the algorithm with the high‐performance RL framework, sample factory, EPPTA significantly reduces convergence time compared to existing pen‐testing methods, resulting in an approximately 20‐fold acceleration. Empirical results across various pen‐testing scenarios validate EPPTA's superior task reward performance and enhanced scalability, providing substantial support for efficient and advanced evaluation of network infrastructure security.
Storage stability and shelf‐life of soymilk obtained via repeated boiling and filtering: A predictive model
Authors: Fan Liu , Duan Yitong , Huang Zhanrui , Zhao Dan , Zhao Liangzhong , He Wanying , Zhang Xuejiao , Li Ming , Lin Yingyi , Chen Yu 
Published: December 2023

AbstractThis study investigated the effects of different processing methods on the quality and nutrition of soymilk, as well as the changes in storage stability (centrifugal sedimentation rate (CSR), viscosity, and particle size) and shelf‐life of soymilk at different storage temperatures (25°C, 35°C, 45°C, and 55°C). Results showed that soymilk processed via the repeated boiling‐to‐filtering method (RBFM) exhibited the highest protein content (3.89 g/100 g), carbohydrate content (1.27 g/100 g), and stability coefficient (0.950). The CSR and particle size of RBFM soymilk increased gradually during storage at different temperatures, while the viscosity and sensory score decreased. The correlation between the CSR and the sensory score of RBFM soymilk was the highest (R2 = .9868). The CSR was selected as the key indicator to predict the shelf‐life of RBFM soymilk. The average residual variation in RBFM soymilk shelf‐life based on the predictive model was 10.78%, indicating the strong accuracy of the model for predicting the shelf‐life of RBFM soymilk stored at temperatures ranging from 25–45°C. This study provides a theoretical basis and technological support for the development, transportation, and storage of soymilk and soymilk beverage products.
KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma: A systematic review
Authors: da Silva Santos Marcos Ezequiel , de Carvalho Abreu Anna Karolina , Martins da Silva Fábio Willian , Barros Ferreira Elaine , Diniz dos Reis Paula Elaine , do Amaral Rabello Ramos Doralina 
Published: December 2023

AbstractBackgroundThe involvement of the KMT2 methyltransferase family in the pathogenesis of head and neck squamous cell carcinoma (HNSCC) remains elusive.MethodThis study adhered to the PRISMA guidelines, employing a search strategy in the LIVIVO, PubMed, Scopus, Embase, Web of Science, and Google Scholar databases. The methodological quality of the studies was assessed by the Joanna Briggs Institute.ResultsA total of 33 studies involving 4294 individuals with HNSCC were included in this review. The most important alteration was the high mutational frequency in the KMT2C and KMT2D genes, with reported co‐occurrence. The expression of the KMT2D gene exhibited considerable heterogeneity across the studies, while limited data was available for the remaining genes.ConclusionsKMT2C and KMT2D genes seem to have tumor suppressor activities, with involvement of cell cycle inhibitors, regulating different pathways that can lead to tumor progression, disease aggressiveness, and DNA damage accumulation.
Emerging advances in fluorescence imaging and phototherapy of arthritis
Authors: Wang Xiaoxuan , Dai Jingying , Shao Cong , Goto Takashi , Dai Honglian 
Published: December 2023

AbstractArthritis is a chronic disease whose etiology is difficult to pinpoint, and the difficulty of arthritis detection and subsequent treatment causes enormous distress to patients. In recent years, thanks to advances in medicine and detection, a variety of treatment modalities for arthritis have emerged. The combination of emerging detection technologies with different anti‐inflammatory medications and even advances in surgical techniques have all played a positive role in the treatment of arthritis. In the present work, we have collected relevant literature on fluorescence (FL) imaging and phototherapy of arthritis in recent years, intending to reveal the advantages and potential application value of FL imaging and phototherapy for researchers. Meanwhile, due to the shortcomings of FL imaging and phototherapy in the diagnosis and treatment of arthritis, we advocate overcoming these difficulties in future research.
Deep learning approach for brain tumor classification using metaheuristic optimization with gene expression data
Authors: Joshi Amol Avinash , Aziz Rabia Musheer 
Published: December 2023

AbstractThis study addresses the critical challenge of accurately classifying brain tumors using artificial intelligence. Early detection is crucial, as untreated tumors can be fatal. Despite advances in AI, accurately classifying tumors remains a challenging task. To address this challenge, we propose a novel optimization approach called PSCS combined with deep learning for brain tumor classification. PSCS optimizes the classification process by improving Particle Swarm Optimization (PSO) exploitation using Cuckoo search (CS) algorithm. Next, classified gene expression data of brain tumor using Deep Learning (DL) to identify different groups or classes related to a particular tumor along with the PSCS optimization technique. The proposed optimization technique with DL achieves much better classification accuracy than other existing DL and Machine learning models with the different evaluation matrices such as Recall, Precision, F1‐Score, and confusion matrix. This research contributes to AI‐driven brain tumor diagnosis and classification, offering a promising solution for improved patient outcomes.
In ovo o,p′‐DDT exposure induces malformation of reproductive organs and alters the expression of genes controlling sexual differentiation in Japanese quail embryo
Authors: Win‐Shwe Tin‐Tin , Abe Natsuko , Sakiyama Akari , Suzuki Maho , Sano Kazuhiro , Kawashima Takaharu , Tsukahara Shinji 
Published: December 2023

AbstractIn ovo exposure to o,p′‐dichloro‐diphenyl‐trichloroethane (o,p′‐DDT) impairs reproduction by inducing malformation of the reproductive organs in birds, although the mechanism remains unclear. Here, we examined the effects of o,p′‐DDT on the development of the reproductive organs, the expression of genes controlling sexual differentiation, and the plasma concentrations of testosterone and estradiol in Japanese quail embryos. o,p′‐DDT‐containing sesame oil was injected into the yolk sac on Embryonic Day (E) 3 at a dose of 500, 2,000, or 8,000 μg per egg. On E15, the reproductive organs were observed; the gonads and Müllerian ducts (MDs) were sampled to measure the mRNA of steroidogenic enzymes, sex steroid receptors, anti‐Müllerian hormone (AMH), and AMH receptor 2 (AMHR2); blood samples were collected to assay plasma testosterone and estradiol levels; and the gonads were used for histological analysis. o,p′‐DDT dose‐dependently increased the prevalence of hypertrophic MDs in females and residual MDs in males. In female MDs, o,p′‐DDT dose‐dependently decreased estrogen receptor (ER) α, ERβ, and AMHR2 mRNA expression. o,p′‐DDT dose‐dependently induced left‐biased asymmetry of testis size, and ovary‐like tissue was found in the left testis after exposure to 8,000 μg per egg o,p′‐DDT, although asymmetric gene expression did not occur. o,p′‐DDT did not affect ovarian tissue but did decrease 17α‐hydroxylase/C17‐20 lyase mRNA expression and dose‐dependently increased ERβ mRNA expression. o,p′‐DDT decreased plasma testosterone concentrations in females. These findings suggest that o,p′‐DDT induces hypertrophy of the MDs and ovarian tissue formation in the left testis. Abnormal MD development may be linked to altered gene expression for sensing estrogens and AMH signals.
Biochemical characterization on muscle tissue of a novel biallelic ACO2 mutation in an infant with progressive encephalopathy
Authors: Ricci Federica Silvia , Stanga Serena , Mezzanotte Mariarosa , Marinaccio Cristina , D'Alessandro Rossella , Somà Alessandra , Sottemano Stefano , Conio Alessandra , Morana Giovanni , Spada Marco , Boido Marina , Mongini Tiziana E. 
Published: December 2023

AbstractThe ACO2 gene encodes the mitochondrial protein aconitate hydratase, which is responsible for catalyzing the interconversion of citrate into isocitrate in the tricarboxylic acid (TCA) cycle. Mitochondrial aconitase is expressed ubiquitously, and deficiencies in TCA‐cycle enzymes have been reported to cause various neurodegenerative diseases due to disruption of cellular energy metabolism and development of oxidative stress. We investigated a severe early infantile‐onset neurometabolic syndrome due to a homozygous novel variant in exon 13 of the ACO2 gene. The in vitro pathogenicity of this variant of unknown significance was demonstrated by the loss of both protein expression and its enzymatic activity on muscle tissue sample taken from the patient. The patient presented with progressive encephalopathy soon after birth, characterized by hypotonia, progressive severe muscle atrophy, and respiratory failure. Serial brain magnetic resonance imaging showed progressive abnormalities compatible with a metabolic disorder, possibly mitochondrial. Muscle biopsy disclosed moderate myopathic alterations and features consistent with a mitochondriopathy albeit nonspecific. The course was characterized by progressive worsening of the clinical and neurological picture, and the patient died at 5 months of age. This study provides the first report on the validation in muscle from human subjects regarding in vitro analysis for mitochondrial aconitase activity. To our knowledge, no prior reports have demonstrated a correlation of phenotypic and diagnostic characteristics with in vitro muscle enzymatic activity of mitochondrial aconitase in humans. In conclusion, this case further expands the genetic spectrum of ACO2 variants and defines a complex case of severe neonatal neurometabolic disorder.