bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary Abscess Secondary to Epididymitis Caused by Extended Spectrum β-Lactamase- Producing Hypervirulent Klebsiella pneumoniae: A Case Report
Authors: Li Runjun , Liu Junlong , Yang Liye , Lin Zhiwei , Rong Ling , Chen Gang , Tang Xiuying 
Published: January 2024

Abstract

Background: Pulmonary abscesses resulting from epididymitis caused by extended spectrum β-lactamase-producing hypervirulent Klebsiella pneumoniae (ESBL-hvKp) in a nondiabetic patientare extremely uncommon.The infection caused by this disseminated drug-resistant bacteria, which is generally considered an intractable case, poses a potential challenge in clinical practice.
Case presentation: In this case report, we present the clinical course of a 71-year-old male patient with epididymitis, who subsequently developed cough and dyspnea following anti-infection treatment. Imaging examinations revealed severe pneumonia and pulmonary abscess. The infection of ESBL-hvKp in the epididymis led to bacteremia and subsequent lung lesions. Due to poor response to anti-infection therapy, the patient required an extended duration of anti-infection treatment and ultimately chosed to discontinue treatment.
Conclusions: Acute epididymitis caused by ESBL-hvKP infection can result in the spread of the infection through the bloodstream, leading to severe pneumonia and lung abscess. Given the critical condition of the patient, even with active anti-infection treatment, there is a risk of treatment failure or potentially fatal outcomes.
Cirsilineol inhibits RANKL-induced osteoclast activity and ovariectomy-induced bone loss via NK-κβ/ERK/p38 signaling pathways
Authors: He Rongxin , Wang Cong , Zeng Rong , Li Yong 
Published: January 2024

Abstract
Background
Postmenopausal osteoporosis is a chronic metabolic bone disease caused by excessive osteoclast formation and function. Targeting osteoclast differentiation and activity can modulate bone resorption and alleviate osteoporosis. Cirsilineol, an active constituent of vestita Wall, has shown numerous biological activities and has been used to treat many metabolic diseases. However, whether cirsilineol inhibits osteoclast activity and prevents postmenopausal osteoporosis still remain unknown.
Materials and methods
Primary bone marrow macrophages (BMMs) and RAW264.7 cells were used. Osteoclast activity was measured by TRAP staining, F-actin staining, and bone resorption assay after BMMs were treated with cirsilineol at concentrations of 0, 1, 2.5 and 5 µM. RT-PCR and western blotting were performed to evaluate the expression of osteoclast-related genes. In addition, female C57BL/6 mice underwent OVX surgery and were treated with cirsilineol (20mg/kg) to demonstrate the effect of cirsilineol on osteoporosis.
Results
Cirsilineol significantly inhibited receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclast differentiation in a concentration- and time-dependent manner, respectively. Additionally, cirsilineol inhibited F-actin ring formation, thus reducing the activation of bone resorption ability. Cirsilineol suppressed the expression of osteoclast-related genes and proteins via blocking nuclear factor (NF)-κβ, ERK, and p38 signaling cascades. More importantly, cirsilineol treatment in mice with osteoporosis alleviated osteoclasts hyperactivation and bone mass loss caused by estrogen depletion.
Conclusion
In this study, the protective effect of cirsilineol on osteoporosis has been investigated for the first time. In conclusion, our findings prove the inhibitory effect of cirsilineol on osteoclast activity via NK-κβ/ERK/p38 signaling pathways and strongly suggest that the application of cirsilineol can be proposed as a potential therapeutic strategy.
Aberrant neural computation of social controllability in nicotine-dependent humans
Authors: Gu Xiaosi , McLaughlin Caroline , Fu Qixiu , Na Soojung , Heflin Matthew , Fiore Vincenzo 
Published: January 2024

Abstract

Social controllability, defined as the ability to exert influence when interacting with others, is crucial for optimal decision-making. Inability to do so might contribute to maladaptive behaviors such as drug use, which often takes place in social settings. Here, we examined nicotine-dependent humans using fMRI, as they made choices that could influence the proposals from simulated partners. Computational modeling revealed that smokers under-estimated the influence of their actions and self-reported a reduced sense of control, compared to non-smokers. These findings were replicated in a large independent sample of participants recruited online. Neurally, smokers showed reduced tracking of forward projected choice values in the ventromedial prefrontal cortex, and impaired computation of social prediction errors in the midbrain. These results demonstrate that smokers were less accurate in estimating their personal influence when the social environment calls for control, providing a neurocomputational account for the social cognitive deficits in this population.
Anticoagulant therapy for a patient with recurrent pulmonary embolism and warfarin resistance：a case report and literature review
Authors: Sen Li , Chen Chen , Yihui Liu 
Published: January 2024

Abstract

Background
Warfarin serves as a primary anticoagulant in the management of pulmonary embolism. This paper delves into the complexities of anticoagulant therapy in a patient demonstrating resistance to warfarin with recurrent pulmonary thromboembolism.
Case presentation:
A 62-year-old female patient was admitted due to recurrent pulmonary embolism, prompting the initiation of anticoagulant therapy. The dosage of enoxaparin was increased by 1/3 − 1/4 to address the severity of the condition. However, subsequent warfarin therapy revealed resistance, with the patient displaying homozygosity for the VKORC1-1639G > A variant and possessing CYP4F2 *3, GGCX with the wild-type CC, indicative of rapid warfarin metabolism. Detailed inquiry into lifestyle revealed habitual consumption of over 7 cups (200 mL/cup) of strong green tea daily, potentially contributing to warfarin resistance. Treatment adjustments were made, recommending a controlled warfarin dose of 12.0 mg to maintain an international normalized ratio of 2.12.
Conclusions
Warfarin resistance is influenced by diverse clinical factors. Accurate identification of this resistance is crucial to tailor anticoagulant therapies effectively. A personalized treatment plan, incorporating consideration of underlying comorbidities, concomitant medications, and dietary nuances, is essential. This case highlights the need for a holistic approach in managing warfarin resistance, ensuring optimal outcomes for patients.
Red blood cell parameters as biomarkers of retinopathy of prematurity in preterm infants born before 30 weeks of gestation
Authors: Maeda Hajime , Go Hayato , Iwasa Hajime , Hiruta Shun , Ichikawa Hirotaka , Sugano Yukinori , Ogasawara Kei , Momoi Nobuo , Sekiryu Tetsuju , Hosoya Mitsuaki 
Published: January 2024

Abstract

Retinopathy of prematurity (ROP) is a major cause of preventable blindness in preterm infants. The association between red blood cell (RBC) parameters and the development of ROP remains unclear. The objectives of the present study were to evaluate the association between RBC parameters and ROP treatment. This single-center, retrospective cohort study included preterm infants born at < 30 weeks of gestation. Data pertaining to RBC parameters and ROP treatment were obtained from the medical records. A receiver operating characteristic (ROC) analysis was performed to determine the cut-off values of the RBC parameters according to the need for ROP treatment. Multiple logistic regression analyses assessed the association between ROP treatment and RBC parameters at birth and on day of life (DOL) 28. We included 202 infants, and 44.1% were treated for ROP. After adjusting for confounders, associations between ROP treatment and hemoglobin (Hb) values of < 9.9 g/dL (adjusted odds ratio [aOR]:3.0; 95% confidence intervals [CI]:1.4–6.7) and hematocrit (Hct) values of < 31.0% (aOR:2.7; 95% CI:1.3–5.6) on DOL 28 were detected. In conclusion, our study showed that infants born at < 30 weeks of gestation with Hb < 9.9 g/dL and Hct < 31.0% on DOL 28 had an increased risk of receiving ROP-warranting treatment.
Prediction of Augmented Efficiency between Electric Pulses and Bleomycin on K562 and MIA-PACA2 Cancer Cells Using Adaptive Neuro-Fuzzy Inference System Method
Authors: Mirshahi Salim , Mirshahi Neshat , Mirshahi Sepideh , Aryana Kiarash , Far Anita Farzaneh , Sazgarnia Ameneh 
Published: January 2024

Abstract
Cell membranes always respond to electric fields because cell membranes consist of ions and molecules. For many years, the technique of inducing electric pulses into the cell to increase its permeability has been investigated. When rectangular pulses with a train of high voltage (about 1000 V/cm) and low repetition frequency (about 1 Hz) are applied, patients feel an unpleasant sensation, while electroporation (EP) using higher repetition frequency and low voltage (HFLV) has been shown to have a higher inhibition of tumor growth. The current study aimed to predict synergism between EP and Bleomycin (SEPB) affecting K562 and MIA-PACA2 cancer cells and to optimize repetition frequency and electric pulse amplitude for HFLV EP by sampling a wide variety of different sets of pulse specifications on SEPB. Both cell types were exposed to higher frequency (4–6 kHz) and low voltage (50–150 V/cm). The characteristics of electric pulses that generate effective synergism with a small dose of Bleomycin were determined. As an output of the applied electric pulses with arbitrary frequency and voltage, the resulting synergism can be achieved using a theoretical model based on an adaptive neuro-fuzzy inference system (ANFIS). Results showed a significant correlation between experimentally observed and theoretically predicted data regarding the calculated coefficient of determination (R2 = 0.99 for K562 and 0.86 for the MIA-PACA2 cell type). It is concluded that this model is intensely reliable for prediction. This suggests that the model is valid and can calculate the SEPB that is affected by the magnitude of the electric pulse and the repetition frequency. Applying the prior experimental results to future drug delivery or biophysical applications might suggest this approach as a time and resource-saving alternative to conducting more tests.
Improved drought forecasting in Kazakhstan using machine and deep learning: a non-contiguous drought analysis approach
Authors: Sadrtdinova Renata , Perez Gerald Augusto Corzo , Solomatine Dimitri P. 
Published: January 2024

Abstract

Kazakhstan is recently experiencing an increase in drought trends. However, low-capacity probabilistic drought forecasts and poor dissemination have led to a drought crisis in 2021 that resulted in the loss of thousands of livestock. To improve drought forecasting accuracy, this study applies Machine Learning and Deep Learning (ML and DL) algorithms to capture the sequences of drought events using a non-contiguous drought analysis (NCDA). Precipitation, 2-m temperature, runoff, solar radiation, relative humidity, and evaporation were collected from the ERA5 database as input variables. Combinations of inputs were used to build ML models, including seven classifiers (Logistic, K-NN, Kernel SVM, Decision Tree, Random Forest, XGBoost, and GRU). The output events were defined by standardized precipitation index (SPI) and SPEI indicators as binary classes. Weekly time series from 1991 to 2021 for each cell were used to forecast a lead time from 1 week to 6 months. GRU provided 97–99% accuracy in more volatile regions while Random Forest and XGBoost showed 94–99% accuracy at a lead time of 6 months. The accuracy evaluation was based on the confusion matrix and F1 score to analyze the stage change capture. This study demonstrates the effectiveness of using ML and DL algorithms for drought forecasting, with potential applications for other regions.
Treatment of Refractory p53 Mutation Large B-cell Lymphoma with Daratumumab and Venetoclax Followed by CAR-T Cell Therapy: Case Report and Animal Study
Authors: Gong Duanhao , Gu Jia , Zhou Kuangguo , Huang Wei 
Published: January 2024

Background::
The tumor burden before chimeric antigen receptor T (CAR-T) cell
therapy was one of the critical factors affecting the prognosis of lymphoma. It was a challenge
to effectively reduce the tumor burden of relapsed/refractory large B-cell lymphoma with p53
mutation.

Objective::
Here, we have presented a case of relapsed/refractory large B-cell lymphoma with
p53 mutation being controlled by the treatment with daratumumab and venetoclax, followed by
CAR-T cell therapy.

Case Presentation::
The patient was a 56-year-old female who was diagnosed with relapsed/
refractory diffuse large B cell lymphoma (DLBCL) transformed from follicular lymphoma.
The patient was treated with daratumumab, venetoclax, and GEMOX (gemcitabine and
oxaliplatin) under the guidance of high-throughput drug sensitivity analysis. We used a CD38
positive lymphoma cell line with p53 mutation to construct tumor models for validating the anti-
lymphoma effect of the combination therapy of daratumumab and venetoclax.

Results::
The patient achieved a complete metabolic response after treatment with daratumumab,
venetoclax, and GEMOX. Then, she further achieved a complete molecular response after she
subsequently received CAR-T cell therapy, and she has been living without a lymphoma recurrence.
The results from the animal study showed that the combination of daratumumab and venetoclax
could significantly enhance the antitumor effect on CD38-positive lymphoma with p53
mutation./

Conclusion::
The results from our successful case and animal experiments provide new avenues
for the treatment of relapsed/refractory large B-cell lymphoma with p53 mutation. Further clinical
trials are reuqired to treat CD38-positive lymphoma with the combination of daratumumab
and venetoclax.
Could the Propionic Acid Treatment in Combination with Metformin be
Safe for the Small Intestine of Diabetic Rats?
Authors: Natrus Larysa , Lisakovska Olha , Smirnov Anton , Osadchuk Yuliia , Savosko Serhyi , Klys Yuliia 
Published: January 2024

Background:
Effects of propionic acid (PA) on the cellular and molecular processes
in the small intestine under type 2 diabetes mellitus (T2DM)-induced endoplasmic reticulum
(ER) stress remain incompletely studied.

Objectives:
The aim of the study was to assess the state of unfolded protein response (UPR)
system in the small intestine of diabetic rats and to explore PA’s influence on metformin treatment.

Methods:
Male Wistar rats were divided into 1) control and 2) T2DM groups, and groups receiving
(14 days, orally) 3) metformin (60 mg/kg), 4) PA (60 mg/kg), and 5) PA+metformin.
Western blotting, RT-PCR, and transmission electron microscopy were performed.

Results:
We found that T2DM induced elevation of ER intermembrane space and UPR overactivation
based on increased GRP78, ATF6 and PERK levels in small intestine. Metformin
treatment led to a further UPR activation. PA supplementation partially restored enterocytes
functioning via normalization of ATF6 and PERK content, while IRE1 level reached the maximum
value, compared to all groups. The most pronounced effect of adaptation to the T2DMinduced
ER stress was observed after combined metformin and PA action. In particular, decreased
ER intermembrane space in enterocytes was detected compared to separate metformin
and PA administration, which was accompanied by restored GRP78, PERK and IRE1 levels.

Conclusion:
Our study proves the safety of additional therapy with propionic acid in combination
with metformin for the functional state of small intestine. Due to its ability to modulate
UPR signaling, PA may be considered a safe and perspective candidate for supportive therapy
in T2DM, especially for neuroprotection.
Cognitive Rehabilitation For Early-Stage Dementia: A Review
Authors: Dhankhar Sanchit , Sharma Prerna , Chauhan Samrat , Saini Monika , Garg Nitika , Singh Randhir , Kamal Mohammad Amjad , Sharma Satish Kumar , Rani Nidhi 
Published: January 2024

:
In the primary phases of Alzheimer's disease (AD) and vascular dementia,
memory impairments and cognitive abnormalities are common. Because of the rising
prevalence of dementia among the elderly, it is critical to promote healthy habits that
can delay the onset of cognitive decline. Cognitive training (CT) and cognitive rehabilitation
(CR) are particular treatments aimed to resolve memory and further areas of cognitive
working in order to overcome these challenges. These are some of the different
kinds of non-pharmacological treatments like reality orientation and skills training programs
that can be used to deal with the cognitive and non-cognitive repercussions. The
purpose of this review is to assess the efficacy and influence of cognitive training and
cognitive rehabilitation in patients who are in their early phases of Alzheimer's disease or
vascular dementia. These interventions are geared toward improving the patients'
memory, in addition to other aspects of their cognitive functioning.
Spectroscopic Analysis of Lipsticks for the Traces of Heavy Metals: A
Comprehensive Review
Authors: Kumari Supriya , Thakur Shailey , Bhardwaj Leena , Kumar Vijay 
Published: January 2024

Abstract:
Heavy metal impurities are typically discovered in cosmetic products since
they are abundant naturally. Lipstick's metal concentration has raised health concerns
across the globe. This is so because applying cosmetics to the face always starts with
lipstick. Since they are a potential source of daily, widespread, and frequently longterm exposure to a range of chemicals, the safety of cosmetic and personal care products has come under increased scrutiny in recent years. Hazardous heavy metals are
included in cosmetics and other products in general, which can cause a multitude of
health issues. Therefore, they ought to be kept to a minimum use wherever it is technically feasible. Analysing the levels of harmful heavy metals present in commercially available cosmetic products is important for reducing exposure to those substances.
In this study, we investigated the levels of a few harmful heavy metals in lipsticks,
such as lead, cadmium, nickel, arsenic, and chromium. For this purpose, we have
studied around 50 research articles that explain the spectroscopic analysis of lipsticks
for the traces of heavy metals. This article includes the determination of levels of these toxic heavy metals by Atomic Absorption Spectroscopy. Due to its hyphenated nature, low cost, quick analysis time, and reliable results, the atomic absorption spectroscopic (AAS) methodology is currently the one that is most frequently employed for
metal ion detection despite the availability of a number of other methods.
Evaluation of Degree of Consolidation, Over Consolidation Ratio and Coefficient of Consolidation from CPTu tests in Alluvium Clays
Authors: Lie Edwin , Lim Aswin 
Published: January 2024

Soft soil was found in several areas in Indonesia, one of them is in Kalimantan Island, which the soft soil in the island mostly formed by Alluvium. One of the characteristics of the soft soil is that they are likely still in under consolidating stage. The usage of CPTu was found to be suitable to the soft soil as the device can record small numbers continuously and able to record pore water pressure. Key features in performing CPTu in under consolidating soft soil is the dissipation test. However, often the dissipation test ended before the 50% excess pore pressure dissipated, which causes commonly used method for interpretation unable to estimate u50. Inverse time (Whittle et. al., 2000; Lim et. al., 2014) and inverse square root time (Liu et. al., 2014) method was developed to overcame the limitation. Rahardjo et. al. (2016) also developed method for obtaining degree of consolidation (and OCR) using pore pressure ratio parameter (Bq) obtained from CPTu. Geotechnical investigation comprised advancing several cone penetration testings (CPTu) were carried out after failure occurred in a relatively flat area (RL +5m to +12m) after having built waste dump embankment to +70m elevation. Soft soil with 15m to 30m thickness was found beneath the embankment. This paper presents comparison of coefficient of consolidation using Teh Houlsby (1991) method using parameters derived from inverse time and inverse square root time, also comparison for degree of consolidation and OCR in the Alluvium clays based on the dissipation data obtained from the testings. Result showed that the Alluvium clays in the upper 10m already over consolidated while between RL 0 to -20m are still under consolidating, with parameters obtained using inverse time and inverse square root time generally showing close value.
Feasibility and Design Factors for Home-Based Pulmonary Rehabilitation of Patients With Chronic Obstructive Pulmonary Disease and Chronic Lung Diseases Based on a People-Object-Environment Framework: Qualitative Interview Study
Authors: Chien Shih-Ying , Wong Alice May-Kuen , Tseng Winston , Hu Han-Chung , Cho Hsiu-Ying 
Published: January 2024

Background
The feasibility of implementing home-based pulmonary rehabilitation (PR) can be assessed from the perspectives of patients with chronic lung disease and health care professionals involved in PR.

Objective
Through a qualitative inquiry using interviews and the adoption of the people-object-environment framework, this study aims to understand the influences of interpersonal, environmental, and situational factors on the perceptions and considerations of individuals involved in home-based PR for patients with chronic lung disease.

Methods
One-on-one interviews were conducted with 20 patients with chronic lung disease and 20 health care professionals for investigating their attitudes and opinions based on their experiences regarding home-based PR as well as for identifying the key factors affecting the benefits and drawbacks of such therapies. This study further evaluates the feasibility of using digital tools for medical diagnosis and treatment by examining the technology usage of both parties.

Results
The 4 key issues that all participants were the most concerned about were as follows: distance to outpatient medical care, medical efficiency, internet connectivity and equipment, and physical space for diagnosis and treatment. Interviews with patients and health care professionals revealed that the use of technology and internet was perceived differently depending on age and area of residence. Most participants reported that digital tools and internet connectivity had many benefits but still could not solve all the problems; moreover, these same digital tools and network transmission could lead to problems such as information security and digital divide concerns. This study also emphasizes the significant impact of human behavior and thinking on shaping the design of health care interventions and technologies. Understanding user perspectives and experiences is crucial for developing effective solutions for unmet needs.

Conclusions
The results of this study indicate that despite the different perspectives of patients and health care professionals, their considerations of the key issues are very similar. Therefore, the implementation of plans related to telemedicine diagnosis, treatment, or rehabilitation should take the suggestions and considerations of both parties into account as crucial factors for telehealth care design.