bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asylum seekers’ and refugees’ experiences of violence and accessing healthcare in the UK: a systematic review
Authors: Hanwell Krystyna , Finnerty Fionnuala , Richardson Daniel 
Published: January 2025

Abstract

Background
This systematic review aimed to characterize the violence, explore the experiences of accessing health services, and highlight any strategies used to improve the access and experiences of healthcare for asylum seekers and refugees in the UK.

Methods
EMBASE, EMCARE, MEDLINE, CINAHL, and Web of Science were searched in February 2024. We included manuscripts that included asylum seekers or refugees who had accessed healthcare settings in the UK. The Joanna Briggs Institute tools were used to assess risk of bias, and data were synthesised narratively.

Results
Twelve manuscripts were included in this review published between 2004 and 2023. The violence experienced by asylum seekers and refugees was characterized as domestic violence, family violence, torture, and sexual violence. There are vulnerability and cultural issues, health issues, and health innovations that affect the experiences and access to healthcare by asylum seekers and refugees. Providing holistic antenatal and midwifery services, reducing language barriers, addressing specific health needs, and careful use of digital health innovations can improve the access and healthcare experiences of asylum seekers and refugees.

Conclusion
These data provide public health and healthcare services some insight into how to provide culturally safe, accessible healthcare for asylum seekers and refugees in the UK.
Integrated care management for patients following acute stroke: a systematic review
Authors: Eustace Ian , Buckley Benjamin J R , Kaya Isik , Hoad Katie L , France-Ratcliffe Madeleine , Hill Andrew R , Lip Gregory Y H , Jones Ian D , Higginbotham Karen 
Published: January 2025

Abstract

Background
Contemporary stroke care is moving towards more holistic and patient-centred integrated approaches, however, there is need to develop high quality evidence for interventions that benefit patients as part of this approach.

Aim
This study aims to identify the types of integrated care management strategies that exist for people with stroke, to determine whether stroke management pathways impact patient outcomes, and to identify elements of integrated stroke care that were effective at improving outcomes.

Design
Systematic review with meta-analysis.

Methods
The review was conducted using Medline, CINAHL, Web of Science and the Cochrane Database of randomised controlled trials from January 2012 to January 2024. Studies that evaluated interventions as part of integrated care against a control or standard treatment group were included. Primary outcomes included mortality, recurrent stroke and major bleeding. Secondary outcomes included quality of life, unplanned readmission, anxiety and depression, lifestyle and cardiovascular risk factors, and adherence to intervention.

Results
In total, 99 studies were included and 63 were meta-analysed. Patients receiving integrated stroke care had significant reductions in recurrent stroke (RR 0.79, 95% CI: 0.63-1.00, P = 0.05, I 2 = 39%), significant improvements in quality of life (SMD = 0.41, 95% CI: 0.26-0.56, P &lt; 0.00001, I 2 = 91%) and reduced incidence of depression (RR 0.95, 95% CI: 0.92-0.99, P = 0.007, I 2 = 22%). There were no significant differences in mortality or major bleeding.

Conclusion
The findings of this study showed that integrated care post-stroke is associated with better quality of life and reduced depression and recurrent stroke.
Interpersonal Discrimination as a Potential Source of Individual-Level Anomie and its Consequences for Suicide Ideation
Authors: Graham Carlyn 
Published: January 2025

ABSTRACT
The relationship between interpersonal discrimination and suicidality has received increasing attention. However, research has not considered whether this relationship differs between independent forms of discrimination and how exposure to multiple forms may relate to suicidality among U.S. adults. Drawing from neo-Durkheimian paradigms of anomie, I conceptualize interpersonal discrimination as a potential source of individual-level anomie and then delineate how the attribute behind discrimination could matter to suicidal thoughts. I further consider how experiencing multiple forms of discrimination may amplify the risk of suicidality. To investigate my theoretical propositions, I use 2016–2018 data from U.S. adults ages 33–43 in the National Longitudinal Study of Adolescent to Adult Health to compare the associations between three forms of discrimination—racial/ethnic, biological sex, and body weight—and suicide ideation, and then consider how experiencing multiple forms relates to suicide ideation. Principal findings indicate that weight discrimination has a stronger positive association with suicide ideation than racial/ethnic- or sex discrimination, but individuals who experienced all three forms had an especially high risk of suicide ideation. This study underscores how the attribution behind discrimination matters to the risk of suicidal thoughts and that exposure to multiple forms increases its likelihood.
The Performance of the Acoustic Change Complex Versus Psychophysical Behavioral Measures: A Systematic Review of Measurements in Adults
Authors: Meehan Sarah , van der Schroeff Marc P. , Adank Marloes L. , Bramer Wichor M. , Vroegop Jantien L. 
Published: January 2025

Objectives:
The acoustic change complex (ACC) is a cortical auditory evoked potential that shows promise as an objective test of the neural capacity for speech and sound discrimination, particularly for difficult-to-test populations, for example, cognitively impaired adults. There is uncertainty, however, surrounding the performance of the ACC with behavioral measures. The objective of this study was to systematically review the literature, focusing on adult studies, to investigate the relationship between ACC responses and behavioral psychophysical measures.

Design:
Original peer-reviewed articles conducting performance comparisons between ACCs and behavioral measures in adults were identified through systematic searches. The review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for reporting, and the methodological quality of the included articles was assessed.

Results:
A total of 66 studies were retrieved that conducted adult ACC measurements, of which 27 studies included performance comparisons. Meta-analysis revealed a total of 41 significant correlations between ACC responses (amplitudes, latencies, and thresholds) and behavioral measures of speech perception (2 weak, 28 moderate, and 11 strong correlations), and 12 significant moderate/strong correlations were identified with behavioral measures of frequency discrimination.

Conclusions:
This systematic review finds that ACC responses are associated with speech perception and frequency discrimination, in addition to other types of sound discrimination. The choice of evoking stimuli, ACC outcome measure, and behavioral measure used may influence the strength and visibility of potential correlations between the objective (ACC) and behavioral measures. The performance of the ACC technique highlighted in this review suggests that this tool may serve as an alternative measure of auditory discrimination when corresponding behavioral measures prove challenging or unfeasible.
Primary Cutaneous Methotrexate-Associated T-Cell Lymphoproliferative Disorder in the Setting of Autoimmune Disease: A Case Series and Review of the Literature
Authors: Nocco Sarah , Magro Cynthia 
Published: January 2025

Abstract:
Methotrexate (MTX), an antimetabolite targeting certain autoimmune conditions and various hematologic malignancies, has been associated with iatrogenic lymphoproliferative disease (LPD) primarily of B-cell lineage. Less commonly are T-cell neoplasms where primary skin involvement is considered rare. Three cases were encountered in the medical practice of one of the authors. The patients ranged in age from 38 years to 99 years (2 women and 1 man) with 2 having rheumatoid arthritis and 1 having ankylosing spondylitis. All 3 patients received MTX. The cases included subcutaneous peripheral T-cell lymphoma not otherwise specified (NOS) (1 patient), mycosis fungoides (1 patient), and a primary aggressive epidermotropic cytotoxic T-cell lymphoma (1 patient) that proved to be fatal. One patient had spontaneous regression following MTX withdrawal; she later developed a recurrence while off MTX. Two patients died, 1 of unrelated causes and 1 of lymphoma. Seven previously reported cases included subcutaneous panniculitis-like T-cell lymphoma (2 cases), primary cutaneous CD4+ LPD (2 cases), peripheral T-cell lymphoma (NOS) (1 case), anaplastic large cell lymphoma (1 case), and peripheral T-cell lymphoma localized to fat (1 case). Regression without recurrence occurred in 6 of the 7 patients with MTX withdrawal. The patients were on the MTX for an average of 4 years and had a median age of 61 years with a slight dominance of men over women. Three of the 7 cases showed Epstein–Barr encoding region (EBER) positivity while the 3 cases reported in this series were negative. MTX-associated T-cell LPD involves older patients on long-term MTX where EBER positivity is more frequent than extracutaneous MTX-associated T-cell LPD. A spectrum of classic forms of CTCL is seen with subcutaneous involvement representing a significant percentage of cases. Regression with MTX withdrawal occurs although not in every case.
Intensive Care Unit Memories and Trauma Triggers for Acute Respiratory Distress Syndrome Survivors Hospitalized During the COVID-19 Pandemic
Authors: Peach Brian C. , Arkin Laura C. , Esparza Lindsey , Hassan Sara , Shinn Leah 
Published: January 2025

Background
Intensive care unit (ICU) admissions can be traumatic for critically ill, ventilated acute respiratory distress syndrome (ARDS) patients due to fear of death, an inability to verbally communicate, reliance on health care professionals, and invasive medical interventions. Adult ARDS patients hospitalized during the COVID-19 pandemic were strictly isolated and had limited to no visitation from loved ones, impacting their access to support systems.

Objective
To explore the memories and sensory triggers for them (if applicable) of adult ARDS survivors hospitalized during the COVID-19 pandemic.

Methods
This study used a phenomenological design with an interpretative descriptive approach. Semistructured interviews with open-ended questions were conducted with survivors. Thematic analysis of 16 ARDS survivors’ responses to ICU memories and sensory triggers questions was completed to identify the most prevalent themes.

Results
Major themes for vivid memories included (1) altered reality, (2) vivid nonsense dreams, (3) medical treatment/procedures, and (4) feeling lonely/isolated. Themes for triggers included (1) seeing doctors/nurses/hospitals and medical equipment or seeing/hearing media depictions of them, (2) hearing ringtones and beeping/alarms, (3) seeing/hearing helicopters, (4) smelling cleaning products, and (5) seeing/touching scars.

Discussion/Conclusions
Fifteen of the 16 ARDS survivors reported traumatic vivid memories, often triggered by sensory stimuli they encountered in their everyday lives. It is important for acute care and outpatient nurses to understand the impact of an ICU admission on ARDS survivors’ mental health, so they can adopt evidence-based interventions to prevent or limit these effects.
Evaluation of the Effect of Nurse-Driven Algorithm in Prevention of Central Catheter–Related Bloodstream Infections in Intensive Care Units
Authors: Acun Aysun , Çalışkan Nurcan 
Published: January 2025

Background
Infection control in intensive care units is important for both patients’ quality of life and institutions.

Aim
This study was conducted to evaluate the effect of a nurse-driven algorithm in preventing central catheter–related bloodstream infections in intensive care units.

Methods
This intervention research was implemented in a training and research hospital in Turkey between July 1, 2021, and December 31, 2021. The research was carried out in 3 stages after the creation of the algorithm. The data were collected using the Descriptive Characteristics Form for Nurses, the Descriptive and Medical Characteristics Form for Patients, the algorithm knowledge test, and the Algorithm Parameters Follow-up form. After obtaining the necessary permissions for the study, consent was obtained from the nurses participating in the study. Number, percentage, Wilcoxon, Kruskal-Wallis, and Mann-Whitney U test values were used in the study.

Results
With the algorithm, a decrease was found in the rate of infections in the intensive care units.

Conclusion
As a result, it was observed that the nurse-driven, central catheter–related bloodstream infection prevention algorithm, prepared using evidence-based clinical guidelines, reduced the rates of infection. Therefore, it is recommended to use algorithm studies as a long-term guide in intensive care units.
How the Consideration of Spiritual Types Could Help in Coping With Moral Distress in Intensive Care
Authors: Kubitza Jenny , Handtke Violet , Mächler Ruth , Teutsch Dagmar , Frick Eckhard 
Published: January 2025

Background
Moral distress is highly prevalent among health care workers in intensive care in which spirituality has been identified both as a risk factor for moral distress and as a resource to mitigate it.

Objectives
Considering these contradictory findings, this study examined why moral distress is perceived in different ways and to what extent spirituality influences the ability to cope with moral distress.

Methods
In a qualitative study in German-speaking countries, semistructured interviews were evaluated using thematic analysis and typology construction according to Stapley et al.

Results
Between May and September 2022, a sample of 13 health care professionals (nurses, physicians, physiotherapists, respiratory therapists) from Germany and Austria was interviewed. Three types of spirituality among critical care staff are identified: (1) the religious type, (2) the dignity type, and (3) the instrumental type. Depending on the type of spirituality, intensive care providers experience moral distress differently and therefore require different resources to cope with moral distress.

Discussion
Appropriate spiritual interventions are facilitated by respecting different spiritualities as potential resources for mitigating moral distress. This preliminary study permits the differentiation of types of spirituality in critical staff and of appropriate supporting interventions.
Continuous peripheral nerve blocks for pain control after orthopaedic surgery
Authors: Espinoza Ana María , Leyton Patricio A. , Robles Marcia , Vargas Javiera , Muñoz Loreto A. 
Published: January 2025

BACKGROUND
Continuous peripheral nerve blocks (CPNB) provide an opioid-free alternative for pain control after orthopaedic surgery. However, postdischarge ambulatory patient care and follow-up concerns have prevented CPNB use at home.

OBJECTIVE
To address physicians’ concerns about the outpatient use of CPNB.

DESIGN
Prospective, cohort, observational study.

SETTING
Single centre, teaching private hospital in Santiago, Chile, between July 2016 and March 2020.

PATIENTS
We included patients aged at least 18 who underwent orthopaedic surgery using CPNB for postoperative pain management. Patients scheduled simultaneously for non-orthopedic surgery on the same event were excluded.

MAIN OUTCOME MEASURES
Pain scores, opioid use, and complication rates at both in-hospital and at-home sites.

RESULTS
CPNB were provided as an analgesia plan in 497 patients who met inclusion criteria, and 387 (77.87%) were discharged home with this continuous analgesia. At 48 h, 70% of the patients reported no-worse-than-mild pain. Less than 3.1% of patients reported an episode of severe pain, and less than 13% of the patients required opioid rescue medication. Transient neurological symptoms were observed in 13% (95% confidence interval (CI), 10.4 to 16.1) of the patients. No long-term or severe complications were observed. High rates of satisfaction were reached among patients.

CONCLUSION
In-hospital and at-home use of CPNB supervised by a pain service team provides a feasible and safe alternative after orthopaedic surgery, pain control with a low requirement of opioids.
Refinement of the Graft-over-Host Technique in Penetrating Keratoplasty
Authors: Hu Daniel J. , Zhang Casey , Hu Jerry G. 
Published: January 2025

Purpose:
We describe a refinement of the graft-over-host technique that eliminates the open-sky phase and reduces the use of additional sutures beyond what is needed for the traditional open-sky technique.

Methods:
This study is a surgical technique description and retrospective case review. For surgical technique, first, trephinate the recipient cornea to 90% depth. Dissect the cornea button, preserving the cardinal attachments. Secure the donor disc over the recipient cornea button with cardinal sutures. Complete the dissection of the cardinal attachments on the underlying recipient cornea button. Slide the recipient cornea button out from under the donor cornea disc. Place additional sutures for the additional securitization of donor disc. For data collection and analysis of surgical outcomes, we conducted a retrospective chart review for 35 patients who underwent the traditional open-sky technique and 28 patients who underwent the graft-over-host technique.

Results:
There were no cases of intraoperative complications including suprachoroidal hemorrhage and vitreal prolapse between both open-sky and graft-over-host cohorts. There were no significant differences in visual acuity between the cohorts at 6-month and 1-year follow-ups.

Conclusions:
Although penetrating keratoplasty may be an increasingly less common surgery, the risks associated with the open-sky phase persist. Surgeons may consider using the graft-over-host technique described in this study to reduce intraoperative risk while minimizing suture utilization, tissue manipulation, and associated operative time.
Comparative Analysis of 2 Commercially Available Assays for Therapeutic Drug Monitoring of Infliximab and Adalimumab
Authors: López Pérez Juan , Inda-Landaluce Mercedes , Nocito-Colón Mercedes , Martínez-Lostao Luis 
Published: January 2025

Background:
Tumor necrosis factor is a crucial proinflammatory cytokine in immune-mediated diseases. Tumor necrosis factor inhibitors (TNFi), such as infliximab and adalimumab, effectively treat rheumatological and digestive disorders. However, challenges such as primary nonresponse, secondary treatment failure, or adverse reactions limit their efficacy. Monitoring TNFi levels is essential for optimizing treatment and improving outcomes. An enzyme-linked immunosorbent assay (ELISA; Promonitor) was compared with 2 commercially available methods for quantifying infliximab and adalimumab levels: the chemiluminescence assay (i-Track10) and fluorescence assay (Afias-10).

Methods:
Serum samples from 166 patients with inflammatory bowel disease were analyzed. Drug levels were measured using i-Track10, Afias-10, and Promonitor. Spearman's correlation analysis, Bland–Altman analysis, analysis of differences, Passing–Bablok regression, and Cohen kappa for agreement assessment were used for statistical analysis.

Results:
Strong correlations were observed between Promonitor and Afias-10 for infliximab (rs = 0.982) and adalimumab (rs = 0.972), and with i-Track10 (rs = 0.935 for infliximab, rs = 0.947 for adalimumab). However, significant differences indicated noninterchangeability with ELISA. Passing–Bablok regression showed systematic and proportional biases. Cohen kappa exhibited higher concordance with Afias-10 for therapeutic ranges (κ = 0.962 for infliximab, κ = 0.849 for adalimumab) compared with i-Track10.

Conclusions:
Afias-10 and i-Track10 are suitable for TNFi monitoring but are not interchangeable with ELISA. Consistent assay methods should be used for patient monitoring to ensure accuracy and reliability.
On-TRACC Pilot Study: A Novel Intervention for Persistent Post-Concussive Cognitive Symptoms
Authors: Pagulayan Kathleen F. , Rau Holly K. , Sheppard David P. , Shulein Orli M. , Onstad-Hawes Emma , Hoffman Jeanne M. , Williams Rhonda M. 
Published: January 2025

Objective: To present the results of a pilot study of On-TRACC (Tools for Recovery and Clinical Care), a novel intervention for individuals experiencing persistent cognitive difficulties after mild traumatic brain injury (mTBI). On-TRACC is a 5-session, 1:1 manualized treatment that integrates psychoeducation, cognitive rehabilitation strategies, and self-management skills to target symptoms and increase understanding of the interaction between cognitive difficulties, injury history, and comorbid medical and psychological conditions. The primary study goals were to evaluate the feasibility, acceptability, and preliminary effectiveness of On-TRACC. Setting: Veterans Affairs medical center and an academic medical center. Participants: Veterans and civilian adults (n = 28) >3 months post-mTBI with current self-reported cognitive difficulties. Design: In this single-group, open-label pilot study, all participants received On-TRACC (5 sessions) via video-based telehealth. Main Measures: Primary measures were feasibility (eg, session attendance and homework completion rate, dropout rate, and treatment fidelity) and acceptability (treatment satisfaction/helpfulness ratings). Preliminary effectiveness was explored by measuring pre- to post-intervention change in cognitive symptom level and attribution, perceived self-efficacy, use of compensatory strategies, daily functioning, quality of life, and planned future engagement in health care. Results: The On-TRACC completion rate for all enrolled participants was 79% (with 88% treatment completion rate for participants who started On-TRACC); homework was fully or partially completed for 98% of attended sessions. Treatment satisfaction ratings were high, with 95% satisfied with the information and skills learned. There were no adverse events. Positive pre- to posttreatment changes were seen in cognitive self-efficacy, symptom attribution, functional status, quality of life, and planned engagement in care for comorbid conditions. Conclusion: On-TRACC was a feasible and acceptable intervention for individuals with chronic cognitive difficulties following mTBI. Additional research, including a randomized clinical trial, is needed to evaluate the efficacy of this intervention and its long-term impact on outcomes in this clinical population.
Addition by Subtraction: Reversing Epikeratophakia and Stromal Scarring in a Patient With Myopia Magna
Authors: Wendelstein Jascha A. , Freller Katrin , Riaz Kamran M. , Seiler Theo G. 
Published: January 2025

Purpose:
To describe a three-phase surgical approach for managing progressive visual decline in a patient with myopia magna and a history of epikeratophakia.

Methods:
A 55-year-old woman with previous epikeratophakia surgery in both eyes experienced progressive visual deterioration. The three-phase approach included: (1) removal of the epikeratophakia lenticule, (2) cataract extraction with intraocular lens implantation, and (3) transepithelial topography-guided photorefractive keratectomy (trans-PRK). Preoperative and postoperative refraction, corneal topography, and visual acuity were assessed.

Results:
After trans-PRK, the right eye exhibited regularization of the corneal surface, with a final best spectacle-corrected acuity of 0.15 logMAR. A similar two-phase approach without lenticule removal was applied to the left eye, resulting in improved visual outcomes.

Conclusions:
A three-phase surgical approach combining lenticule removal, cataract surgery, and topography-guided PRK offers a potential pathway for visual improvement in patients with phakic postepikeratophakia.