bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anomalies of the right hepatic artery in periampullary cancers treatment: are pathological and clinical outcomes different? A single tertiary referral center retrospective analysis
Authors: De Sio Davide , Lucinato Chiara , Panza Edoardo , Quero Giuseppe , Laterza Vito , Schena Carlo Alberto , Fiorillo Claudio , Taglioni Flavia , Menghi Roberta , Longo Fabio , Rosa Fausto , Tortorelli Antonio Pio , Tondolo Vincenzo , Alfieri Sergio 
Published: December 2023

Abstract
Purpose
Anomalies of the right hepatic artery (RHA) may represent an additional challenge in pancreatoduodenectomy (PD). Aim of this study is to assess the potential impact of variations in hepatic arterial anatomy on perioperative outcomes.
Methods
PDs performed for periampullary malignancies between 2017 and 2022 were retrospectively enrolled. Patients were, thus, subdivided according to the pattern of vascularization into: modal pattern of vascularization (MPV) and anomalous pattern of vascularization (APV). A 2:1 propensity-score matching (PSM) analysis was conducted to homogenize the two study populations. The two groups were then compared in terms of peri-operative outcomes and pathological findings.
Results
Thirty-eight patients (16.3%) out of 232 presented a vascular anomaly: an accessory RHA in 7 cases (3%), a replaced RHA in 26 cases (11.2%) and a replaced HA in 5 cases (2.1%). After PSM, 76 MPV patients were compared to the 38 APV patients. Incidence rate of post-operative complications was comparable between the two study populations (p = 0.2). Similarly, no difference was detected in terms of histopathological data, including margin status. No difference was noted in terms of perioperative hemorrhage (p = 0.6). No patients needed an arterial resection.
Conclusion
When PDs are performed in high-volume centers, the presence of anomalies of the RHA do not relate to a significant impact on perioperative complications. Moreover, no influence was noted in terms of histopathological findings.
Biomechanics of the osseous bridge formation in the atlas vertebra as a consequence of the intentional cranial deformation
Authors: Ortega-Ruiz Ricardo , Felip Antonio Ros 
Published: December 2023

Abstract

From more than 5,000 years ago until the Conquest, practices aimed to cause permanent cranial deformities in individuals were common in pre-Columbian societies. Its purpose was to produce signs of identity of different types: religious, magical, aesthetic, ethnic or social. These modifications were made with boards, fabrics, and elastic straps that applied pressure to the newborn's head. There are many morphological variants, but a classification into four groups is generally accepted: Straight Circular, Oblique Circular, Straight Tabular and Oblique Tabular. In the anthropological investigation of bone samples from the archaeological site of the Huallamarca pyramid (Lima, Peru), the classification process collected a significant sample with oblique tabular deformation, which show a variant of simultaneous deformation in both the skull and the bone. from the atlas. In this first cervical vertebra the so-called Ponticulus Posticus is shown, a bony bridge resulting from bone remodeling, in which one of the theories about its origin is its generation due to the alteration of natural loads of the neck joint. The purpose of this article is the development and application of biomechanical techniques to verify this point of view, focusing the study on the one hand on the correlation between possible changes in the location of the center of gravity of the skull and, on the other, the consequent changes of loads on the atlas as a result of the intentional shape change of the skull.
Optimization of ecological water replenishment in water-deficient rivers by coupling hydrodynamic model and optimization algorithm——A case study of the Beijing section of Yongding River
Authors: LIANG Yuhang , Li Zhaoyong , Li Xiaolin , Gou Shaojie , Li Guanghe , Bai Tao , Yang Moyuan , Wang He 
Published: December 2023

Abstract
In view of the subjectivity and limitations of traditional scenario setting in devising ecological water replenishment scheme for water-deficient rivers, as well as problems such as time-consuming computations and the difficulty of obtaining global optimal solutions, this paper proposes an ecological water replenishment optimization model coupling a hydrodynamic model and an optimization algorithm. By leveraging the hydrodynamic model to obtain relationship curves between various hydrodynamic indicators (e.g., water level, discharge, flow velocity) under different ecological water replenishment scenarios, and combining these curves with the optimization algorithm, the model aims to obtain the most optimal water replenishment scheme to meet specific objectives. Using the ecological water replenishment project in the Beijing section of the Yongding River as a case study, the model calculates the minimum thresholds of the water replenishment flow of the Guanting Reservoir are 3 m3/s and 30 m3/s, respectively, when the Mountain Gorge section and the Beijing section of Yongding River are in the state of full-channel waterflow connectivity. On the premise of the maximum guarantee rate of suitable ecological flow in Sanjiadian section, the highest monthly average ecological water replenishment efficiency from Guanting to Sanjiadian section and the maximum guarantee rate of full-channel waterflow connectivity, this study proposes a comprehensive optimal ecological water replenishment scheme to make each goal in a better state as much as possible, which not only provides novel insights and methodologies for the formulation of ecological water replenishment scheme for the Yongding River, but also holds important reference value for the development of ecological water replenishment scheme of other water-deficient rivers.
Reference Lactobacillus strains as Potential Antimicrobial Agents Against Priority Pathogens with Different Levels of Drug Resistance
Authors: Shah Vidhi , Soni Richa , Dabhi Milan , Goswami Dweipayan , Joshi Rushikesh 
Published: December 2023

Abstract
Probiotics are beneficial microorganisms that can exert antibacterial activity against pathogenic bacteria. In this study, we evaluated the antibacterial activity of probiotics reference strains of, Lactobacillus acidophilus(LA, NCDC Accession No. 13), Lactobacillus casei(LC, NCDC Accession No. 17), and Lactobacillus plantarum(LP, NCDC Accession No. 20) against twelve pathogens, some of which are classified as High priority by the World Health Organization (WHO) due to their extensive antibiotic resistance. The probiotics were obtained from the National Collection of Dairy Cultures (NCDC); National Dairy Research Institute (NDRI), Karnal; India as reference strains. The pathogens were isolated from clinical samples and identified by Matrix-Assisted Laser Desorption Ionization Time-Of-Flight (MALDI-TOF) mass spectrometry, while their antibiotic resistance profiles were identified using VITEK®2. The antibacterial activity of the probiotics was measured by two standard methods (agar well diffusion and agar slab method). The zone of inhibition and the antagonistic activity of the probiotics were recorded and compared. All three probiotics exhibited antibacterial activity against all 12 pathogens, with varying degrees of inhibition and antagonism. The study demonstrated that lactobacilli strains from NDRI had shown to be effective in inhibiting the growth of WHO-priority pathogens.
Study protocol for a randomized controlled trial using VISIONARY, a dichoptic Gabor patch video game, to improve visual function in children with amblyopia
Authors: Pérez-Benito Maria , Calderón-González Teresa , Álvarez-Martín Esther , Martín-González Santiago , Portela-Camino Juan A. 
Published: December 2023

Abstract
Background: Conventional treatment for amblyopia, involving occlusion and penalization of the dominant eye, does not always lead to effective outcomes and is associated with a high risk of recurrence and non-compliance. In this article, we present a protocol for a randomized controlled trial to evaluate the safety and clinical efficacy of Visionary, a novel computer-based therapy that uses dichoptic Gabor patches and band-filtered noise to treat amblyopia in the patient’s home.
Methods: Our aim is to recruit a total of 120 children with amblyopia, aged 4–12 years, from the Paediatric Ophthalmology Unit at the Merida Hospital in Badajoz (Spain). The children will be divided into two groups according to whether or not they have previously undergone treatment involving occlusion or penalization of the dominant eye: 60 participants with no history of occlusion or penalization treatment will be assigned to Group A (GA), while Group B (GB) will consist of 60 participants who have previously received treatment with an occlusion dose > 32 weeks in mild or moderate amblyopia or > 48 weeks in severe amblyopia.
In GA, the participants will be randomly assigned to either an experimental subgroup (GA-E) or a control subgroup (GA-C). Members of the GA-E group will be prescribed home therapy using computer-based exercises (Visionary); members of the GA-C group will be prescribed occlusion according to Pediatric Eye Disease Investigation Group (PEDIG) protocols.
In GB, all participants will receive occlusion according to PEDIG protocols, and all will be prescribed home therapy using Visionary. In the experimental subgroup (GB-E), the computer will adjust the training spatial frequency of the Gabor patch, taking into account the user’s visual acuity (VA); while in the control subgroup (GB-C), the spatial frequency will remain low, irrespective of the patient’s VA.
Visual function assessments will be carried out prior to the intervention and every three weeks thereafter; changes in best corrected visual acuity (BCVA) at distance will be the primary outcome measure under consideration. Stereoacuity and patient compliance will also be assessed.
Discussion: The Visionary system based on dichoptic Gabor patches was originally conceived as a serious game to provide vision training to amblyopic children by combining the concepts of perceptual learning, dichoptic training, and gamification in the home environment. We hope that this novel approach may lead to greater improvements in vision performance in amblyopic children, as a substitute for occlusion treatment in novel amblyopia or as an adjunct treatment option in persistent amblyopia.
Trial registration: This protocol was registered with ClinicalTrials.gov (NCT06150391) on 29th of November 2023.
Comparative Biowaiver Study of Moxifloxacin in Immediate Release of Oral Solid Dosage Form
Authors: Siraj Zahid , Adil Omair , Amin Bakht , Tahiri Iftikhar Ahmed 
Published: December 2023

Abstract
Biowaiver is based on a Bio-pharmaceutical Classification System (BCS), and it is used to waive in-vivo studies of test products that are intended for registration from drug regulatory authorities. After certain in-vitro testing, the BCS tells whether the test product is “bioequivalent” to the reference or innovator product or not. Bioequivalence is needed to check the risks arising from the presence of different excipients in the formulation and due to manufacturing variables being deemed to be low. Moxifloxacin is a fluoroquinolone antibiotic drugs with a wide therapeutic index. It shows a broad spectrum of antibacterial activity against both Gram-positive and Gram-negative pathogens. Here, In-vitro biowaiver study of moxifloxacin was conducted based on Biopharmaceutical Classification System (BCS). Out of four BCS classes, moxifloxacin falls in class I which represents high solubility and high permeability. One innovator and five test brands of Moxifloxacin tablets were collected from the local market and their in-vitro dissolution study was performed by using pharma test DT 70 apparatus at different time (15, 30, 45 and 60 minutes), in three buffer systems i.e., hydrochloric acid buffer (pH 1.2), acetate buffer (pH 4.5) and phosphate buffer (pH 6.8). Biowaiver of moxifloxacin tablet is scientifically justified the dosage form of the reference product is rapidly dissolving (85% in 15 min) in all three buffers. Interestingly, we found low-cost alternative test products that show similar dissolution profiles to the reference product in these buffers. Therefore, the biowaiver study of moxifloxacin provides evidence that the test products are bioequivalent with innovator products which leads to provision of cost effective and alternative drug product.
Invariant EKF based 3D Active SLAM with Exploration Task
Authors: Xu Mengya , Chen Shengduo , Huang Shoudong , Zhao Liang , Hao Qi 
Published: December 2023

Abstract

Right invariant extended Kalman filter (RIEKF) based simultaneous localization and mapping (SLAM) has shown to be able to produce more consistent SLAM estimates as compared with traditional EKF based SLAM methods. In this paper, RIEKF algorithm is used to solve active SLAM problem for 3D indoor environments with exploration task. A combined planner which combines an efficient global planner with an accurate local planner is proposed. Both the predicted SLAM results for candidate control actions and the actual estimated SLAM results after applying the selected control actions are computed using RIEKF algorithms. Simulation and real-world results under different scenarios have shown that the proposed RIEKF based active SLAM algorithm can explore unknown environments more efficiently with more accurate SLAM estimate. The code is made publicly available.
The effect of intense pulsed light on the ocular surface microenvironment of patients with dry eye associated with meibomian gland dysfunction
Authors: Song Wenjing , Cheng Yu , Yan Xiaoming , Yang Songlin 
Published: December 2023

Abstract
Purpose: To investigate the effect of IPL on the bacterial flora of the palpebral margin of patients with dry eye disease (DED)-associated meibomian gland dysfunction (MGD).
Methods: All subjects were accepted 3 times IPL combined with expression of the meibomian gland (MGX) in the clinic. Cultures were obtained from the margin of the eyelid of the right eyes. Two swabs were taken from each patient at the following time points: Before treatment and the patient completed the first treatment. All swabs were taken for culture and analyzed for bacteria, anaerobic bacteria, and fungi. Tear break-up time (TBUT) was measured before and after 3 weeks of each treatment. Corneal fluorescent staining (CFS), meibomian gland evaluator, lid margin congestion (LMC), and the SPEED questionnaire were evaluated at the beginning and the final follow-up.
Results: The bacterial load of the eye lid reduced significantly after IPL treatment. Staphylococcus epidermidiswas the bacterium most frequently isolated and was observed in 55% of all patients before the first treatment with IPL. The CFS, SPEED, and LM score was reduced and the TBUT and MGE score improved after 3-times IPL treatment. Specifically, TBUT improved at every follow-up time. The improvement in the SPEED score and the improvement in the MGE score were correlated with the improvement in TBUT.
Conclusions: IPL treatment could reduce the bacterial load of the eyelid margin, improve the TBUT, MGE, and SPEED score. It is a comprehensive treatment for DED as it could improve several OSM factors.
Continuous adiabatic frequency conversion for FMCW-LiDAR
Authors: Mrokon Alexander , Oehler Johanna , Breunig Ingo 
Published: December 2023

Abstract
Continuous tuning of the frequency of laser light is the cornerstone for a plethora of applications in basic science as
well as in the industrial environment. They range from the hunt for gravitational waves, the realization of optical
clocks over health and environmental monitoring to distance measurements. So far, it is difficult to combine a wide
tuning range (> 100 GHz) with sub-microsecond tuning times, intrinsic tuning linearity and coherence lengths
beyond 10 m. We show that electro-optically driven adiabatic frequency converters using high Q microresonators
made of lithium niobate are able to transfer arbitrary voltage signals into frequency chirps on time scales far below
1 μs. The temporal variation of the frequency nicely agrees with the one of the voltage applied. The corresponding coefficient of determination is
R2 > 0.999. The coherence length of the emitted light is of the order of 100 m. In order to prove these findings,
we apply linear frequency sweeps for FMCW LiDAR for distances between 0.5 and 10 m without any signs of
nonlinearity. Our results show that electro-optically driven adiabatic frequency
converters can be used in applications that require ultrafast and flexible continuous frequency tuning with intrinsic
linearity and large coherence length.
Research on grinding performance of electroplated coarse-grained diamond grinding wheel by dressing
Authors: Deng Shibo , Xia Yongqi , Ni Binkun , Wu Mingtao 
Published: December 2023

Abstract
In precision grinding of hard and brittle materials, coarse-grained diamond grinding wheels are increasingly favored for their efficiency and contour accuracy. However, challenges in dressing these grinding wheels have hindered their widespread adoption. In this paper, the effects of dressing parameters on the surface profile and morphological characteristics of electroplated coarse-grained diamond were studied, thereby optimizing the dressing accuracy and dressing efficiency of the coarse-grained diamond grinding wheel. Models for the surface morphology of the large-grained diamond grinding wheel and its grinding surface were established. With a focus on optimizing dressing accuracy, we explored how the grain's protruding height post-dressing affects the surface morphology of both the diamond grinding wheel and the grinding surface. The model's accuracy was verified by electroplated coarse-grained diamond grinding wheel grinding experiments with different grain protrusion heights, and the causes of surface morphology formation were analyzed based on morphological characteristic parameters such as surface roughness and surface height difference. The results showed that compared with the undressed grinding wheel, the surface roughness Sa and Sq of the workpiece by the dressing wheel are reduced by 97.75%-99.77% and 97.57%-99.73%, respectively. Precision dressing enables the surface roughness of the electroplated coarse-grained diamond grinding wheel to reach nanometer levels, enhancing its feasibility and application potential.
Trust to reduce risk in a market without quality signals
Authors: Mignot Sylvain , Vignes Annick 
Published: December 2023

Abstract
This article analyses the determinants of loyalty on a market for perishable goods, where there exists no label or quality signal and quantities can be scarce. This daily market exhibits a specific bi-organization. Every morning, agents can choose between bidding or exchanging through bilateral transactions. Surprisingly, this organization is a stable one and it sounds like an economic paradox. Our hypothesis is that agents behave in a different way according to their level of information, trust or reputation. It is well accepted in economy that trust plays an important role in transactions but its definition and measurement stay, as far as we know, very elusive. This article provide a measurement of loyalty, based on the dynamics of agents' encounters. It brings into the light that, when the transaction links on the auction market reflects the economic constraints of the partners, the network of relationships on the bilateral market depends on something more. Our results help to understand the distinctive characteristics and functioning of each sub-market. This discussion contributes to the debate about the efficiency of market structures.
Plastic Waste Recycling For Development Of Bito-Plastic Roads In Educational Institutions For Sustainable Pathways
Authors: Babu Sri. G. Nani , Krishna KVSG Murali , kousalya G. , babji K. 
Published: December 2023

Abstract
India is facing top ten challenges out of those plastic wastes Management is priority matter. India is leading the way in their development in many fields like S&T, Automation, Robotics for ease of operations in Waste Management. Plastic waste generation in India is about 4.13 million metric tons per annum, of which 20–30% is recycled. The top 5 states in India for producing plastic waste are Telangana, Tamil Nadu, West Bengal, Uttar Pradesh, and Karnataka. India has built about 33,800 km of plastic roads up to this point. India has already built over 33,000 km of plastic roads and is planning to build even more in the future. This is a significant step in the right direction in the fight against plastic pollution. each kilometer of plastic road requires 9 tons of bitumen and 1 ton of plastic waste. One ton of bitumen can be saved for every kilometer of plastic road built. The abstract plastic roads are one of the best ways to easily dispose of waste plastics and that they can help to reduce plastic pollution. It also highlights the potential of plastic roads to strengthen road building and make it more affordable.
Enhancing preclinical speech-language pathology students’ self-perceived clinical competence using simulated patients
Authors: Ma Estella P.-M. , Lee Taiying , Li Wing-hong 
Published: December 2023

Abstract
Objective
This study aimed to evaluate the impact of preclinical simulation-based learning experience in reducing student anxiety in interacting with real patients and enhancing their self-perceived clinical competence.
Method
Second-year undergraduate speech-language pathology (SLP) students undertaking a preparatory course for clinical work and placement participated. Two clinical case simulation sessions were embedded as part of this course. In each session, two professional actors role-played as caregivers of family members with communication disorders. The first simulation focused on foundational assessment skills, and students were required to obtain a case history with the simulated caregivers. The second simulation targeted intervention and students presented caregivers with appropriate communication strategies. Students’ self-perceived level of skills, confidence and anxiety were assessed before and after the simulation sessions.
Design:
Pre-post design.
Results
Students reported significant increases in their confidence level following simulation sessions. They perceived themselves as much better prepared for working with real patients in upcoming clinical placements.
Discussion
Simulation-based learning experience in a controlled environment enhances preclinical SLP students’ perceived confidence levels and clinical competence.
Maternal genetic diversity analysis of Guanling cattle by mitochondrial genome sequencing
Authors: Xu Longxin , Wang Xin , Wang Hua , Wu Junda , Zhou Wenzhang , Ni Mengmeng , Zhang Kaikai , Zhao Yuanfeng , Lin Ruiyi 
Published: December 2023

Abstract

Owing to the unique geography and the isolated environment, Guanling cattle, which is one of five local breeds in Guizhou, China, has developed unique characteristics. The number of pure Guanling cattle decreased markedly because of the hybridization with foreign breeds. In the present study, the maternal genetic diversity of 58 Guanling bulls was assessed by whole mitochondrial genome sequencing. Genetic polymorphisms and phylogenetic analyses classified Guanling cattle into two main lineages, where 43.10% of Guanling cattle were closely related to the foreign breeds and 56.90% displayed distinct features in mitochondrial genomic diversity. PCA analysis further separated Guanling cattle into four populations, one of which was clustered with the foreign breeds. The result of the structure plot and genetic polymorphism revealed high genetic diversities within two populations that have a long genetic distance from the foreign breeds. Overall, our findings suggest that the whole mitochondrial genome sequencing analysis is a useful and reliable tool to study maternal genetic diversity and to identify the pure population of Guanling cattle. The results will be beneficial to the breeding management of Guanling cattle.