bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of large language models in medical counseling: A focus on Helicobacter pylori infection
Authors: Kong Qing‐Zhou , Ju Kun‐Ping , Wan Meng , Liu Jing , Wu Xiao‐Qi , Li Yue‐Yue , Zuo Xiu‐Li , Li Yan‐Qing 
Published: February 2024

AbstractBackgroundLarge language models (LLMs) are promising medical counseling tools, but the reliability of responses remains unclear. We aimed to assess the feasibility of three popular LLMs as counseling tools for Helicobacter pylori infection in different counseling languages.Materials and MethodsThis study was conducted between November 20 and December 1, 2023. Three large language models (ChatGPT 4.0 [LLM1], ChatGPT 3.5 [LLM2], and ERNIE Bot 4.0 [LLM3]) were input 15 H. pylori related questions each, once in English and once in Chinese. Each chat was conducted using the “New Chat” function to avoid bias from correlation interference. Responses were recorded and blindly assigned to three reviewers for scoring on three established Likert scales: accuracy (ranged 1–6 point), completeness (ranged 1–3 point), and comprehensibility (ranged 1–3 point). The acceptable thresholds for the scales were set at a minimum of 4, 2, and 2, respectively. Final various source and interlanguage comparisons were made.ResultsThe overall mean (SD) accuracy score was 4.80 (1.02), while 1.82 (0.78) for completeness score and 2.90 (0.36) for comprehensibility score. The acceptable proportions for the accuracy, completeness, and comprehensibility of the responses were 90%, 45.6%, and 100%, respectively. The acceptable proportion of overall completeness score for English responses was better than for Chinese responses (p = 0.034). For accuracy, the English responses of LLM3 were better than the Chinese responses (p = 0.0055). As for completeness, the English responses of LLM1 was better than the Chinese responses (p = 0.0257). For comprehensibility, the English responses of LLM1 was better than the Chinese responses (p = 0.0496). No differences were found between the various LLMs.ConclusionsThe LLMs responded satisfactorily to questions related to H. pylori infection. But further improving completeness and reliability, along with considering language nuances, is crucial for optimizing overall performance.
Hepatitis B surface antigen glycan isomer is a predictor of the development of hepatocellular carcinoma during nucleoside/nucleotide analog therapy
Authors: Kozuka Ritsuzo , Enomoto Masaru , Yukawa‐Muto Yoshimi , Odagiri Naoshi , Kotani Kohei , Motoyama Hiroyuki , Kawamura Etsushi , Hagihara Atsushi , Fujii Hideki , Uchida‐Kobayashi Sawako , Kawada Norifumi 
Published: February 2024

AbstractAimA recombinant monoclonal antibody against the hepatitis B surface antigen glycan isomer (HBsAgGi) was newly developed using the O‐glycosylated PreS2 peptide in M‐HBsAg of hepatitis B virus (HBV) genotype C. However, the association between HBsAgGi and the development of hepatocellular carcinoma (HCC) during nucleoside/nucleotide analog (NA) therapy remains unknown.MethodsA total of 112 HBV genotype C‐infected patients who were treated with NA were included in this study. We assessed the association between HBV markers, including HBsAgGi and other conventional markers, and the development of HCC during NA therapy.ResultsTen patients developed HCC during the follow‐up period. Of the HBV markers, HBsAg (≤3.53 log IU/mL; p = 0.047), HBsAgGi/HBsAg ratio (≥1.10; p = 0.035), and HBV DNA (≤6.3 log copies/mL; p = 0.012) at baseline and HBsAg (≤3.19 log IU/mL; p = 0.033) and HBsAgGi/HBsAg ratio (≥1.09; p = 0.003) at 48 weeks after NA therapy were significantly associated with the development of HCC according to the log rank test. In contrast, no significant association was observed between HBsAgGi and the development of HCC. Multivariate analysis revealed that a platelet count at baseline ≤88 × 103/mm3 (p = 0.026; hazard ratio [HR], 10.577) and an HBsAgGi/HBsAg ratio at 48 weeks after NA therapy ≥1.09 (p = 0.040; HR, 10.099) were independently and significantly associated with the development of HCC.ConclusionsOur findings suggest that a combination of on‐treatment HBsAgGi and HBsAg predicts the development of HCC during NA therapy.
Depression care integration in tuberculosis services: A feasibility assessment in Pakistan
Authors: Afaq Saima , Ayub Aliya , Faisal Mehreen Riaz , Nisar Zara , Zala  , Rehman Ateeq ur , Ahmed Afzaal , Todowede Olamide , Siddiqi Najma 
Published: February 2024

AbstractBackgroundThe co‐occurrence of depression among tuberculosis (TB) patients is a critical issue, contributing to poor treatment outcomes, prolonged hospitalisations and increased healthcare expenses.ObjectiveThe objective of this study was to assess the feasibility of delivering a co‐designed depression care pathway within TB services in Pakistan.DesignMixed‐method study.Setting and ParticipantsRoutine depression screening for TB patients was conducted at three TB facilities in Peshawar, Pakistan, encompassing primary, secondary and tertiary care settings. All patients aged 18 or above (male and female) attending the three TB facilities between November 2021 and February 2022 were included in the study using the consecutive sampling technique.ResultsA total of 301 people with confirmed TB, within the past 4 weeks, visited the three TB care facilities; 191/301 patients were screened for depression. Approximately 35% of the 191 TB patients screened positive for depression, with varying severity levels. Qualitative findings highlighted the acceptability of integrated depression care, emphasising the importance of open communication and empathetic attitudes. Barriers to integration include stigma, logistical challenges, patient noncompliance and cost burdens. Facilitators included the empathetic attitude of healthcare providers and the availability of mental health services within the same facility.ConclusionThere is a high burden of depression in patients with TB, highlighting the pressing need for mental health support in this population. Acceptability of integrated care was evident, with factors such as co‐located mental health services, training healthcare providers and provider empathetic attitudes playing a crucial role. Further research is required to evaluate the effectiveness of the integrated TB‐depression screening systems towards improved health outcomes, implementation, scalability and impact on the broader healthcare system.Patient and Public ContributionTo create a more inclusive and comprehensive TB and depression care pathway, we gathered input from both service providers and service users (TB patients, their carers). Reflective meetings with community leaders, social activists and health professionals from various sectors were also conducted during pathway delivery to get their insights. Power, gender and age imbalances were addressed by encouraging participation of patients and carers across gender and age groups. This approach ensured that the perspectives of all stakeholders were considered in the development of the care pathway.
Mechanical properties and microstructure evolution of KD‐SA SiCf/BN/SiC CMCs oxidized at different temperatures
Authors: Li Liuwei , Qin Hao , Liao Chunjing , You Xiao , Luo Han , Xue Yudong , Yue Xuezheng , Yang Jinshan , Zhang Xiangyu , Dong Shaoming 
Published: February 2024

AbstractSilicon carbide fiber‐reinforced SiC ceramic matrix composites (SiCf/SiC CMCs) based on a domestic KD‐SA SiC fiber were exposed to a wet oxygen atmosphere for 135 h at 800, 1100, and 1300°C. The evolution of the microstructure and mechanical properties of SiCf/SiC CMCs have been systematically investigated following oxidation. For weight change, CMC‐1300 showed the greatest gain (0.394%), followed by CMC‐1100 (0.356%) and CMC‐800 (0.149%). The volatilization of boron oxide (B2O3) combined with the slight oxidation of the SiC matrix at 800°C caused crack deflection and fiber pull‐out. The complete dissipation of the interphase could be found when the oxidation temperature increases to 1100°C, generated a fracture surface with brittle fracture characteristics. At 1300°C, crystalline SiO2 hindered oxygen diffusion, with evidence of fiber pull‐out. Based on thermodynamic calculations and microscopic observations, we propose a mechanism to explain the thermal degradation of SiCf/SiC CMCs. This work offers valuable guidance for the fabrication of SiCf/SiC CMCs that are suitable for high‐temperature applications.
Prior hospital attendances in deceased Australian patients with alcohol‐related liver disease: a multicentre project
Authors: Attree Chloe , Fennessy Sean , Jeffrey Gary , Kontorinis Nickolas , Naylor Nola , Hazeldine Simon 
Published: February 2024

AbstractBackground and AimsTo establish the hospital visit history of patients who die with alcohol‐related liver disease (ArLD). To determine if patients with ArLD present to hospital early or in the terminal phase of their disease.MethodsRetrospective cohort study of patients with a history of ArLD who died as an inpatient at three tertiary Western Australian hospitals from February 2015 to February 2017. Hospital records were reviewed to identify the number and cause of emergency department (ED), inpatient and outpatient attendances in all Western Australian public hospitals in the 10 years prior to death.ResultsOne hundred fifty‐nine patients (23% female) had a total of 753 ED, 3535 outpatient appointments, 1602 hospital admissions and 10 755 admission days. Twelve months prior to death, 82% of patients had a public hospital contact and 74% an admission. Patients who had their first hospital contact within 12 months prior to death were significantly more likely to have a liver‐related cause of death (P < 0.01). Aboriginal and Torres Strait Islander patients (15% of cohort) died at a significantly younger age (M = 49.2, SD = 10.5 years) than non‐Aboriginal and Torres Strait Islander patients (M = 59.9, SD = 10.2 years, P < 0.01). Despite having more ED attendances and hospital admissions, Aboriginal and Torres Strait Islander patients had significantly less (P = 0.04) outpatient appointments (Mdn = 5.5, interquartile range [IQR] = 1–18 vs Mdn = 11, IQR = 3–33).ConclusionsMost patients with ArLD have multiple early attendances, which present an opportunity for early interventions. There are missed opportunities for Aboriginal and Torres Strait Islander patients for outpatient hospital engagement.
Understanding the careers of freelancers on digital labor platforms: The case of IT work
Authors: Gussek Lisa , Wiesche Manuel 
Published: February 2024

AbstractOnline freelancing, an alternative form of work where independent workers offer services on digital labor platforms, gains increasing importance in IS research. While the general understanding of this form of work is growing, research lacks understanding careers on digital labor platforms. However, these differ from careers in offline labor markets due to volatility, global matching and platform mediation, the digital and temporary nature of work, and algorithmic management as particular platform working conditions. Therefore, to understand how working conditions on digital labor platforms influence the dynamic career paths of freelancers, we conduct an exploratory analysis using 35 interviews with freelancers and clients on digital labor platforms. We thus contribute to the body of knowledge on alternative forms of work on digital labor platforms by developing a long‐term freelancing career model and outlining the dynamics of advancement, decline, and exit within platform careers. We also illustrate mechanisms between career phases in terms of platform lock‐in effects, which arise from the career advancement dynamics and career exit dynamics.
Intersectionality in Black Maternal Health Experiences: Implications for Intersectional Maternal Mental Health Research, Policy, and Practice
Authors: Gilliam Shantesica M. , Hylick Kandyce , Taylor Erica N. , La Barrie Dominique L. , Hatchett Emily E. , Finch Morgan Y. , Kavalakuntla Yashaswini 
Published: February 2024

IntroductionBlack women experience significant maternal mortality and morbidity disparities in the United States. Although emerging research has focused on reducing maternal mortality rates among Black birthing individuals, we must explore structural and social factors contributing to mental health outcomes during the perinatal period. Gaps exist where intersectional identities and experiences in maternal and child health are examined. This study explores the intersectional stress experiences of Black perinatal women in the South.MethodsWe collected qualitative data through virtual semistructured interviews with 9 pregnant and 7 postpartum participants (N = 16).These interviews assessed feelings, attitudes, and perceptions about psychological stress due to their intersectional experiences of being Black, pregnant, and a woman in the United States. Findings were analyzed through the lens of critical race theory and intersectionality.ResultsWe identified 5 overarching themes: (1) perinatal mental health experiences, (2) birthing and parenting while Black, (3) socioeconomic factors, (4) how we cope, and (5) community and social support.DiscussionOverall, this study revealed how the layers of race, gender, pregnancy, and socioeconomic status influence mental health during the perinatal period. These findings show the need for antiracist and intersectional maternal mental health policies and practices.
The effect of sevoflurane exposure on cell‐type‐specific changes in the prefrontal cortex in young mice
Authors: Zhao Bao‐Jian , Song Shao‐Yong , Zhao Wei‐Ming , Xu Han‐Bing , Peng Ke , Shan Xi‐Sheng , Chen Qing‐Cai , Liu Hong , Liu Hua‐Yue , Ji Fu‐Hai 
Published: February 2024

AbstractSevoflurane, the predominant pediatric anesthetic, has been linked to neurotoxicity in young mice, although the underlying mechanisms remain unclear. This study focuses on investigating the impact of neonatal sevoflurane exposure on cell‐type‐specific alterations in the prefrontal cortex (PFC) of young mice. Neonatal mice were subjected to either control treatment (60% oxygen balanced with nitrogen) or sevoflurane anesthesia (3% sevoflurane in 60% oxygen balanced with nitrogen) for 2 hours on postnatal days (PNDs) 6, 8, and 10. Behavioral tests and single‐nucleus RNA sequencing (snRNA‐seq) of the PFC were conducted from PNDs 31 to 37. Mechanistic exploration included clustering analysis, identification of differentially expressed genes (DEGs), enrichment analyses, single‐cell trajectory analysis, and genome‐wide association studies (GWAS). Sevoflurane anesthesia resulted in sociability and cognition impairments in mice. Novel specific marker genes identified 8 distinct cell types in the PFC. Most DEGs between the control and sevoflurane groups were unique to specific cell types. Re‐defining 15 glutamatergic neuron subclusters based on layer identity revealed their altered expression profiles. Notably, sevoflurane disrupted the trajectory from oligodendrocyte precursor cells (OPCs) to oligodendrocytes (OLs). Validation of disease‐relevant candidate genes across the main cell types demonstrated their association with social dysfunction and working memory impairment. Behavioral results and snRNA‐seq collectively elucidated the cellular atlas in the PFC of young male mice, providing a foundation for further mechanistic studies on developmental neurotoxicity induced by anesthesia.image
Simplifying the injector's armamentarium: An international consensus regarding the use of gel science to differentiate hyaluronic acid fillers and guide treatment recommendations
Authors: Metelitsa Andrei , Enright Kaitlyn M. , Rosengaus Frank , Avelar Luiz , Lam Stephanie , Berros Philippe , Di Gregorio Carlo , Fabi Sabrina , Hamdan Firas , Liew Steven , Minocha Kuldeep , Wanitphakdeedecha Rungsima , Weiner Steven , Nikolis Andreas 
Published: February 2024

AbstractBackgroundThe Restylane portfolio of soft tissue fillers spans a wide range of indications, due in part to their complementary manufacturing technologies [non‐animal stabilized hyaluronic acid (NASHA) and Optimal Balance Technology (OBT/XpresHAn)]. Using an array of products, injectors can achieve a holistic, natural looking effect for their patients. However, with a wide range of products it may be difficult to choose an optimal combination.AimSimplify and align global use recommendations for NASHA versus OBT products.MethodsTwo pre‐meeting surveys were completed by 11 key opinion leaders with international representation, with the goal of collecting information regarding their current injection practices for various anatomical regions of the face (i.e., temporal region, forehead, tear trough, lateral zygoma, anteromedial cheek, nose, pyriform aperture, nasolabial fold, perioral area, lips, labiomental crease, marionette lines, chin, and jawline). The data collected from these surveys was subsequently discussed in a consensus group meeting involving 11 voting members and 3 nonvoting members.ResultsTop product recommendations were identified for each anatomical area, along with secondary and tertiary recommendations that can also be used under defined circumstances. Recommendations were provided based on a consideration of elements such as patient features (e.g., skin thickness, bone structure), the desired aesthetic outcome, experience of the injector, and the preferred injection technique.ConclusionA majority consensus regarding the top NASHA versus OBT product choice for each anatomical region of the face was reached. These recommendations represent international agreement regarding the use of Restylane products.
Readiness for hospital discharge and its association with post‐discharge outcomes among oesophageal cancer patients after oesophagectomy: A prospective observational study
Authors: Yu Qian , He Le‐jian , Zhong Jiu‐di , Zhang Jun‐e 
Published: February 2024

AbstractAimTo examine the level and influencing factors of discharge readiness among patients with oesophageal cancer following oesophagectomy and to explore its association with post‐discharge outcomes (post‐discharge coping difficulty and unplanned readmission).BackgroundOesophageal cancer is common and usually treated via oesophagectomy in China. The assessment of patient's discharge readiness gradually attracts attention as patients tend to be discharged more quickly.DesignProspective observational study. The STROBE statement was followed.MethodsIn total, 154 participants with oesophageal cancer after oesophagectomy were recruited in a tertiary cancer centre in Southern China from July 2019 to January 2020. The participants completed a demographic and disease‐related questionnaire, the Quality of Discharge Teaching Scale and Readiness for Hospital Discharge Scale before discharge. Post‐discharge outcomes were investigated on the 21st day (post‐discharge coping difficulty) and 30th day (unplanned readmission) after discharge separately. Multiple linear regressions were used for statistical analysis.ResultsThe mean scores of discharge readiness and quality of discharge teaching were (154.02 ± 31.58) and (138.20 ± 24.20) respectively. The quality of discharge teaching, self‐care ability, dysphagia and primary caregiver mainly influenced patient's discharge readiness and explained 63.0% of the variance. The low discharge readiness could predict more risk of post‐discharge coping difficulty (r = −0.729, p < 0.01) and unplanned readmission (t = −2.721, p < 0.01).ConclusionsDischarge readiness among patients with oesophageal cancer following oesophagectomy is influenced by various factors, especially the quality of discharge teaching. A high discharge readiness corresponds to good post‐discharge outcomes.Implications for the Profession and Patient CareHealthcare professionals should improve the discharge readiness by constructing high‐quality discharge teaching, cultivating patients' self‐care ability, mobilizing family participation and alleviating dysphagia to decrease adverse post‐discharge outcomes among patients with oesophageal cancer.Patients or Public ContributionPatients with oesophageal cancer after oesophagectomy who met the inclusion criteria were recruited.
The State School Mental Health Profile: Findings from 25 States
Authors: Orenstein Shawn , Yarnell Jordy , Connors Elizabeth , Bohnenkamp Jill , Hoover Sharon , Lever Nancy 
Published: February 2024

ABSTRACTBACKGROUNDState‐level leadership and conditions are instrumental to local and regional comprehensive school mental health system (CSMHS) quality, sustainability, and growth. However, systematic documentation of state‐level school mental health (SMH) policy, infrastructure, funding, and practice is limited.METHODSUsing a multi‐phase, multi‐method process, we developed the State School Mental Health Profile (State Profile) to offer a comprehensive landscape of state SMH efforts. State leaders in 25 states completed the State Profile once over a 3‐year data collection period. Mixed methods results are reported in 8 domains.RESULTSState education agencies were reportedly most involved in SMH technical assistance, advocacy, leadership, funding, and service provision, with mental health agencies reported as second most involved. Nearly half of state respondents reported having a state‐level SMH director or coordinator. Policies with the greatest perceived impact require implementation of and funding for SMH services and supports. Despite leveraging multiple sources of funding, most states emphasized lack of funding as a primary barrier to establishing CSMHSs. All states reported staffing shortages.CONCLUSIONThe State Profile can assist multi‐agency state leadership teams to self‐assess policy, infrastructure, and resources to support CSMHSs statewide. Findings point to areas of opportunity to advance equity across resource allocation, service provision, and policy development.
Stephen King's evolution on race: Re‐reading Duma Key
Authors: Blouin Michael J. , Sederholm Carl H. 
Published: February 2024

AbstractStephen King is at times more self‐reflective about his depictions of blackness than it might seem at first glance. He ruminates upon his own complicated role as a white writer who, on occasion, speaks through the mouths of black characters. King has demonstrated a willingness, especially in his twenty‐first century fiction, to interrogate his biases. Put simply, we should not be too hasty in dismissing (or cancelling) King. To address this further, we propose another look at Duma Key, a novel that scrutinizes the role of popular artists in reinforcing as well as revising ideas about race in America.
Internationalization and innovation: A multilevel meta‐analysis of national sentiments
Authors: Wu Sihong , Fan Di 
Published: February 2024

AbstractInnovation is essential for sustaining the global competitive viability of multinational enterprises (MNEs), yet the internationalization–innovation relationship remains theoretically debatable and empirically inconsistent. To resolve the puzzle and identify the underlying mechanisms that contribute to the mixed findings, this study integrates existing empirical evidence from 298 independent samples and presents a multilevel meta‐analysis. Taking an organizational learning perspective, this study explores two critical yet underexplored national sentiments that can moderate the MNEs' innovation propensity in internationalization, including technologism and nationalism. Our results show that while technologism strengthens MNEs' innovation in internationalization, nationalism weakens it. In addition, the interaction between the national sentiments exerts significant moderating effects on the relationship. Through exploring the novel drivers and barriers at country level, this study generates new and nuanced insights into innovation management in an international context. It also provides important managerial implications and discusses opportunities for future investigations into the complexity of innovation management in an interconnected and competitive world.