bluuebunny/crossref_metadata_2025_split huggingface dataset:
The chemical characteristics of different sodium iron ethylenediaminetetraacetate sources and their relative bioavailabilities for broilers fed with a conventional corn-soybean meal diet
Authors: Wang Shengchen , Wu Bingxin , Zhu Ling , Zhang Weiyun , Zhang Liyang , Wu We , Wu Jiaqi , Hu Yun , Li Tingting , Cui Xiaoyan , Luo Xugang 
Published: January 2024

Abstract
Background
Our previous studies demonstrated that divalent organic iron (Fe) proteinate sources with higher complexation or chelation strengths as expressed by the greater quotient of formation (Qf) values displayed higher Fe bioavailabilities for broilers. Sodium iron ethylenediaminetetraacetate (NaFeEDTA) is a trivalent organic Fe source with the strongest chelating ligand EDTA. However, the bioavailability of Fe when administered as NaFeEDTA in broilers and other agricultural animals remains untested. Herein, the chemical characteristics of 12 NaFeEDTA products were determined. Of these, one feed grade NaFeEDTA (Qf = 2.07 × 108), one food grade NaFeEDTA (Qf = 3.31 × 108), and one Fe proteinate with an extremely strong chelation strength (Fe-Prot ES, Qf value = 8,590) were selected. Their bioavailabilities relative to Fe sulfate (FeSO4·7H2O) for broilers fed with a conventional corn-soybean meal diet were evaluated during d 1 to 21 by investigating the effects of the above Fe sources and added Fe levels on the growth performance, hematological indices, Fe contents, activities and gene expressions of Fe-containing enzymes in various tissues of broilers.

Results
NaFeEDTA sources varied greatly in their chemical characteristics. Plasma Fe concentration (PI), transferrin saturation (TS), liver Fe content, succinate dehydrogenase (SDH) activities in liver, heart, and kidney, catalase (CAT) activity in liver, and SDH mRNA expressions in liver and kidney increased linearly (P < 0.05) with increasing levels of Fe supplementation. However, differences among Fe sources were detected (P < 0.05) only for PI, liver Fe content, CAT activity in liver, SDH activities in heart and kidney, and SDH mRNA expressions in liver and kidney. Based on slope ratios from multiple linear regressions of the above indices on daily dietary analyzed Fe intake, the average bioavailabilities of Fe-Prot ES, feed grade NaFeEDTA, and food grade NaFeEDTA relative to the inorganic FeSO4·7H2O (100%) for broilers were 139%, 155%, and 166%, respectively.

Conclusions
The bioavailabilities of organic Fe sources relative to FeSO4·7H2O were closely related to their Qf values, and NaFeEDTA sources with higher Qf values showed higher Fe bioavailabilities for broilers fed with a conventional corn-soybean meal diet.
Comparison of three different prophylactic treatments for postoperative nausea and vomiting after total joint arthroplasty under general anesthesia: a randomized clinical trial
Authors: Xie Jinwei , Cai Yingcun , Pei Fuxing 
Published: January 2024

Abstract
Background
Postoperative nausea and vomiting (PONV) after total joint arthroplasty is common and associated with delayed recovery. This study was performed to evaluate the efficacy of three different prophylactic regimens for PONV after total joint arthroplasty under general anesthesia.

Methods
Patients undergoing primary total hip or knee arthroplasty were randomized to Group A (ondansetron), Group B (10 mg dexamethasone plus ondansetron and mosapride), or Group C (three doses of 10 mg dexamethasone plus ondansetron and mosapride). The primary outcome was the total incidence of PONV during postoperative 48 h. The secondary outcomes were complete response, rescue antiemetic treatment, opioid consumption, time until first defecation, postoperative appetite score, satisfaction score, length of hospital stay, blood glucose level, and complications.

Results
Patients in Group C experienced a lower incidence of total PONV (29.3%, p = 0.001) and a higher incidence of complete response (70.7%, p = 0.001) than did patients in Group A (51.9%, 48.2%, respectively). Patients in Group C also experienced a lower incidence of severe PONV (4.3%) than patients in Group A (25.9%, p<0.001) and B (20.4%, p<0.001). Moreover, less rescue antiemetic treatment (1.4 ± 0.5 mg Metoclopramide) and postoperative opioid consumption (1.8 ± 0.3 mg Oxycodone, 6.0 ± 1.0 mg Pethidine) was needed in Group C. Additionally, a shorter time until first defecation, shorter length of stay, and better postoperative appetite scores and satisfaction scores were detected in patients in Group C. A slight increase in the fasting blood glucose level was observed in Group C, and the complications were comparable among the groups.

Conclusion
Combined use of ondansetron, mosapride and three doses of dexamethasone can provide better antiemetic effectiveness, postoperative appetite, bowel function recovery, and pain relief than a single dose or ondansetron only.

Trial registration information
The protocol was registered at the Chinese Clinical Trial Registry (ChiCTR1800015896, April 27, 2018).
Potential prognostic determinants for FET::CREB fusion-positive intracranial mesenchymal tumor
Authors: Mezzacappa Frank M. , Smith Frankie K. , Zhang Weiwei , Gard Andrew , Cabuk Fatmagul Kusku , Gonzalez-Gomez Ignancio , Monforte Hector L. , Liang Jiancong , Singh Omkar , Quezado Martha M. , Aldape Kenneth D. , Gokden Murat , Bridge Julia A. , Chen Jie 
Published: January 2024

AbstractIntracranial mesenchymal tumor (IMT), FET::CREB fusion-positive is a provisional tumor type in the 2021 WHO classification of central nervous system tumors with limited information available. Herein, we describe five new IMT cases from four females and one male with three harboring an EWSR1::CREM fusion and two featuring an EWSR1::ATF1 fusion. Uniform manifold approximation and projection of DNA methylation array data placed two cases to the methylation class “IMT, subclass B”, one to “meningioma-benign” and one to “meningioma-intermediate”. A literature review identified 74 cases of IMTs (current five cases included) with a median age of 23 years (range 4–79 years) and a slight female predominance (female/male ratio = 1.55). Among the confirmed fusions, 25 (33.8%) featured an EWSR1::ATF1 fusion, 24 (32.4%) EWSR1::CREB1, 23 (31.1%) EWSR1::CREM, one (1.4%) FUS::CREM, and one (1.4%) EWSR1::CREB3L3. Among 66 patients with follow-up information available (median: 17 months; range: 1–158 months), 26 (39.4%) experienced progression/recurrences (median 10.5 months; range 0–120 months). Ultimately, three patients died of disease, all of whom underwent a subtotal resection for an EWSR1::ATF1 fusion-positive tumor. Outcome analysis revealed subtotal resection as an independent factor associated with a significantly shorter progression free survival (PFS; median: 12 months) compared with gross total resection (median: 60 months; p < 0.001). A younger age (< 14 years) was associated with a shorter PFS (median: 9 months) compared with an older age (median: 49 months; p < 0.05). Infratentorial location was associated with a shorter overall survival compared with supratentorial (p < 0.05). In addition, the EWSR1::ATF1 fusion appeared to be associated with a shorter overall survival compared with the other fusions (p < 0.05). In conclusion, IMT is a locally aggressive tumor with a high recurrence rate. Potential risk factors include subtotal resection, younger age, infratentorial location, and possibly EWSR1::ATF1 fusion. Larger case series are needed to better define prognostic determinants in these tumors.
Geomagnetic paleointensity dating of mid-ocean ridge basalts from the neo-volcanic zone of the Central Indian Ridge
Authors: Yoshimura Yutaka , Fujii Masakazu 
Published: January 2024

AbstractDescribing the evolution of the neo-volcanic zone in the spreading ridge is essential for understanding the dynamics and environments of abyssal basins. However, the absolute dating of ocean floor basalts is generally difficult. As a characteristic age indicator, absolute intensity of past geomagnetic field (absolute paleointensity, API) is useful to date ocean floor basalts. In this study, we adopted the Tsunakawa–Shaw method to measure APIs of whole-rock seafloor basalts collected from a conical cone on the Central Indian Ridge and performed rock magnetic experiments. We conducted the experiments on a total of 18 specimens (two or three specimens from each of eight lava sites). Six specimens from two lava sites with different morphologies (pillow and sheet), three for each, passed the acceptance criteria. API means at site level are 33.0 ± 1.0 and 35.8 ± 1.7 μT, respectively. The similarity of API site means suggests that they erupted within a short period. These site-level API means are approximately 0.7 to 0.8 times the present geomagnetic intensity of 46.0 μT at the sampling sites. The accepted specimens show higher Curie temperature, lower initial intensity of natural remanent magnetization, higher ratio of saturation remanence to saturation magnetization (Mrs/Ms), and signal of harder magnetic mineral than rejected ones. Our primary comparison between the two site-level API means and the 1590–present high-resolution IGRF-13 + gufm1 model constrains that the eruption timing of the conical cone to be < 1590 CE. When we compared the two site-level API means with the paleointensity curves calculated from the BIGMUDI4k.1 and ArchKalmag14 k.r, we found that they overlap in the period of − 7575 to −1675 CE or − 25 to 1590 CE, which may be the eruption timing of the conical cone. We concluded that timing of recent volcanic eruption in abyssal environment could be investigated by using appropriate rock magnetic selection and carefully examined API.
Graphical Abstract
Exploring virus-host-environment interactions in a chemotrophic-based underground estuary
Authors: Ghaly Timothy M. , Focardi Amaranta , Elbourne Liam D. H. , Sutcliffe Brodie , Humphreys William F. , Jaschke Paul R. , Tetu Sasha G. , Paulsen Ian T. 
Published: January 2024

AbstractBackgroundViruses play important roles in modulating microbial communities and influencing global biogeochemistry. There is now growing interest in characterising their ecological roles across diverse biomes. However, little is known about viral ecology in low-nutrient, chemotrophic-based environments. In such ecosystems, virus-driven manipulation of nutrient cycles might have profound impacts across trophic levels. In particular, anchialine environments, which are low-energy underground estuaries sustained by chemotrophic processes, represent ideal model systems to study novel virus-host-environment interactions.ResultsHere, we employ metagenomic sequencing to investigate the viral community in Bundera Sinkhole, an anchialine ecosystem rich in endemic species supported by microbial chemosynthesis. We find that the viruses are highly novel, with less than 2% representing described viruses, and are hugely abundant, making up as much as 12% of microbial intracellular DNA. These highly abundant viruses largely infect important prokaryotic taxa that drive key metabolic processes in the sinkhole. Further, the abundance of viral auxiliary metabolic genes (AMGs) involved in nucleotide and protein synthesis was strongly correlated with declines in environmental phosphate and sulphate concentrations. These AMGs encoded key enzymes needed to produce sulphur-containing amino acids, and phosphorus metabolic enzymes involved in purine and pyrimidine nucleotide synthesis. We hypothesise that this correlation is either due to selection of these AMGs under low phosphate and sulphate concentrations, highlighting the dynamic interactions between viruses, their hosts, and the environment; or, that these AMGs are driving increased viral nucleotide and protein synthesis via manipulation of host phosphorus and sulphur metabolism, consequently driving nutrient depletion in the surrounding water.ConclusionThis study represents the first metagenomic investigation of viruses in anchialine ecosystems, and provides new hypotheses and insights into virus-host-environment interactions in such ‘dark’, low-energy environments. This is particularly important since anchialine ecosystems are characterised by diverse endemic species, both in their microbial and faunal assemblages, which are primarily supported by microbial chemosynthesis. Thus, virus-host-environment interactions could have profound effects cascading through all trophic levels.
The effectiveness of oral bovine lactoferrin compared to iron supplementation in patients with a low hemoglobin profile: A systematic review and meta-analysis of randomized clinical trials
Authors: Christofi Maria-Dolores , Giannakou Konstantinos , Mpouzika Meropi , Merkouris Anastasios , Stylianide Maria Vergoulidou – , Charalambous Andreas 
Published: January 2024

AbstractBackgroundPatients with a low serum blood hemoglobin concentration suffer from a pathologic state that contributes significantly to morbidity and mortality figures worldwide. Oral iron supplementation, the most common method of treatment, is reported to have poor patient adherence, due to its unwanted side effects. Lactoferrin is a globular glycoprotein of the transferrin family that has shown promising results in patients with a low hemoglobin profile. This systematic review and meta-analysis of randomized clinical trials explore its effect on blood hemoglobin compared to conventional iron preparations.MethodsWe followed the PRISMA Guidelines for reporting systematic reviews and meta-analyses. A systematic search was conducted in electronic databases (PubMed, CINAHL, Scopus, and Cochrane) from inception to June 2022. Meta-analysis was performed on studies where the primary outcome was the mean Hb concentration, comparing lactoferrin to ferrous sulfate subgroups. We assessed the methodological quality of the trials using the Jadad scoring scale.ResultsNineteen trials published between 2006 and 2022 met the eligibility criteria. It has been found that the levels of Hb concentration in different populations with varying health conditions undergo a moderate to significant change after treatment with all types of trialed interventions, including both iron and lactoferrin treatment, in both the intervention group and the comparison group. Most of the studies report that LF showed a statistically significant increase in Hb concentration levels, compared to those in the iron group. The meta-analysis included seven trials comparing the effectiveness of lactoferrin to ferrous sulfate for patients with low Hb concentration. The analysis showed a statistically significant increase in Hb levels in the oral bovine lactoferrin group compared to ferrous sulfate (SMD -0.81, 95% CI: -1.21, -0.42,p < 0.0001, I2 = 95.8%, P heterogeneity < 0.001).ConclusionsLactoferrin is an effective intervention at doses of 100–250 ng/day, for patients with a low Hb concentration. As a safer option and with high compliance evidence, lactoferrin can serve as an iron replacement treatment for patients who may be experiencing adverse side effects due to iron intake.
Relationship between food group-specific intake and depression among local government employees in Japan
Authors: Kitabayashi Makiko , Umetsu Shoko , Suzuki Miho , Konta Tsuneo 
Published: January 2024

Abstract
Background
We aimed to examine the relationship between food group-specific intake and depression among workers in Japan.

Methods
A questionnaire survey was administered to 568 workers in 2020; 503 workers responded and 423 were included in the study. Information on sex, age, body mass index, overtime hours, sleep duration, marital status, employment position, exercise habits, smoking status, incidence of depression, and intake of energy, proteins, lipids, carbohydrates, alcohol, and specific food groups were collected. The Center for Epidemiologic Studies Depression Scale was used to assess the presence and severity of depression. Food group-specific intake was adjusted for energy intake using the residual method and classified into low, moderate, and high by sex. Logistic regression was used to examine the odds ratios (ORs) and trends according to sex, with the presence/absence of depression as the dependent variable and food group-specific intake as the independent variable.

Results
Men in the eggs low-intake, and women in the other vegetables low- and moderate-intake and eggs moderate-intake groups had significantly higher adjusted ORs (aORs) for depression. Additionally, a dose-response relationship was observed, where the OR for depression was significantly higher in men when the intake of eggs was low (p for trend = 0.024) and in women when the intakes of other vegetables (p for trend = 0.011) and eggs (p for trend = 0.032) were low.

Conclusions
The intake of eggs in men and eggs and vegetables in women may be related to depression.
A global perspective on household size and composition, 1970–2020
Authors: Esteve Albert , Pohl Maria , Becca Federica , Fang Huifen , Galeano Juan , García-Román Joan , Reher David , Trias-Prats Rita , Turu Anna 
Published: January 2024

AbstractHouseholds are core units of social organization and reproduction, yet, compared to other areas of demographic research, we have limited understanding of their basic characteristics across countries. Using data from 793 time points and 156 countries in the new CORESIDENCE database, this article provides a comprehensive analysis of global household size and composition trends. The findings reveal that despite significant international variations in household size, ranging from 1.8 in Denmark to 8.4 in Senegal, there is a widespread decline in household size. On average, households have decreased by approximately 0.5 persons per decade. Children contribute to over three-quarters of the observed variability and decline in household size in recent decades. In contrast, the number of other relatives in households has remained relatively stable or has only moderately decreased. While households are becoming more similar in size, their composition is not converging globally to the same extent. These dynamics have macro and micro-level implications for families, societies, and the economy. Further investigation is required to understand the underlying factors driving these transformations and their consequences.
IFRS adoption and the readability of corporate annual reports: evidence from an emerging market
Authors: Ebaid Ibrahim El-Sayed 
Published: January 2024

Abstract
This study aims to investigate the impact of adopting International Financial Reporting Standards (IFRS) on the readability of corporate annual reports of Saudi companies. Data have been collected for a sample of 67 companies listed on the Saudi Stock Exchange for the period 2014–2019. Statistical methods such as the independent sample t test, the Wilcoxon matched-pair test, and the multiple regression analysis have been used to examine the effect of adopting IFRS on the readability of the corporate annual report. The results of the study reveal that the adoption of IFRS has led to a decrease in the readability of the corporate annual report. The results also indicate that there is a significant impact of the company’s size and profitability on the readability of the corporate annual report, while the leverage and industry in which the company operates do not have a significant impact on the readability of the corporate annual report. Since the annual reports of Saudi companies are published in Arabic, the study is not able to use the most popular readability indexes in the literature such as the Fog Index, Gunning Fox Index, Flesch–Kincaid Grade Index, and Flesch Reading Ease Index. Instead, the study uses three readability measures appropriate to the readability of annual reports prepared in Arabic, namely report length, report size, and LIX formula. The study contributes to the global debate about the economic consequences of adopting International Financial Reporting Standards (IFRS) by examining the impact of adopting IFRS on the readability of corporate annual reports, considering that this report is the main and official communication tool between the company and its stakeholders. This study is the first study to examine the impact of adopting IFRS on the readability of corporate annual reports in Saudi Arabia as one of the emerging markets.
Management of rhino-orbito-cerebral mucormycosis: a clinico-radiological study—an institutional experience
Authors: Patnaik Monica , Jain Rajat , Singh Abhishek Bahadur , Kumar Sunil , Verma Veerendra 
Published: January 2024

Abstract
Background
Mucormycosis in the setting of COVID-19 has given rise to the concept of “epidemic within a pandemic.” Once known to be a rare fungal disease, mucormycosis has now been regrouped under emerging pathogens. It has got special affinity for the immunocompromised, which is one of the main reasons for the flare up of the fungus during the second wave of COVID. The burden of the disease was felt globally, and India is facing the major brunt owing to our population and healthcare services ratio.

Objective
In our study, we have made an attempt to evaluate the clinical and radiological findings in patients of rhino-orbito-cerebral mucormycosis (ROCM) and to formulate a management protocol which will benefit such patients in forthcoming years.

Methods
This is a retrospective single-center study in Northern India. A total of 350 patients, affected by ROCM, were included in the study. Medical records of these patients were reviewed. Their clinical manifestations, nasal endoscopic findings, microbiological and radiological records, extent of disease, treatment profile, surgical interventions, and outcomes were analyzed. Nasal swab which was sent for KOH mount/fungal culture revealed broad aseptate filamentous fungi branching at right angles. All patients received intravenous amphotericin B and had undergone extensive surgical debridement endoscopically. The maxillary sinus was the commonest paranasal sinus involved followed by the ethmoid sinuses. Tissue sent for histopathological examination confirmed mucormycosis, except for 3 cases.

Results
The commonest presenting symptoms were cheek swelling with ophthalmoplegia, diminution of vision, and headache. The mean duration of follow-up was 8 months.
The maxillary sinus was found to be involved in around 71% of the cases followed by the ethmoids and sphenoid. Thirty percent of the cases had visual complaints including diplopia and vision loss, whereas the palate was involved in around 35%. Nine patients had no perception of light in one eye on presentation, whereas 21 patients had perception of light only; 24 patients could count fingers close to face, and the rest had ambulatory vision. Three patients presented with facial palsy. All patients had favorable outcome except six who succumbed due to cerebral involvement and uncontrolled blood glucose levels.

Conclusion
A definite management protocol was formulated for ROCM which requires a multidisciplinary approach.