bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Ethnoscience Puzzle Guna Mendorong Kemampuan Kognitif Anak Berkebutuhan Khusus
Authors: Oktaviani Eva , Setiyono Imawan Eko 
Published: January 2024

This research aims to develop an ethnoscience puzzle educational game tool to encourage the cognitive abilities of Children with Special Needs (ABK) in special schools. The method used in this research uses Research and Development (R&D) with a 4D approach, namely defining, designing, developing, and disseminating. The results of the expert validation test show that the ethnoscience puzzle is excellent and suitable for use as an educational game tool to improve the cognitive abilities of ABK. A limited trial was carried out on 20 crew members at the elementary school level, and the results showed that most crew members' cognitive assessments did not understand (TMS). Still, they understood (M) after playing using the ethnoscience puzzle. Conclusion: The ethnoscience puzzle game positively influences the cognitive development of ABK.

Keywords: Children with Special Needs, Ethnoscience Puzzle, Special Schools
The Function of Non-Formal Education Institutions in Improving Human Resources
Authors: Ramadhani Tiara , Putri Siska Elasta , Fadri Zainal , Purba Olivia Rovince 
Published: January 2024

This study aims to describe the background of the birth of the Sumatra Volunteer Foundation, analyze the function of the Sumatra Volunteer Foundation and see the impact caused by the presence of the Sumatra Volunteer Foundation as a non-formal education institution in Jorong Balai Labuah, Lima Kaum District, Tanah Datar Regency. This research uses qualitative research methods using a phenomenological approach. The instrument in this study makes the researcher the main instrument. Data were obtained through observation, interviews and document studies. The data that has been collected is analyzed through the stages of data reduction, data presentation, and conclusion drawing. The results of this study indicate that the birth of the Sumatra Volunteer Foundation as a non-formal institution was motivated by the desire to improve the level of education, especially in Jorong Balai Labuah, Lima Kaum District, Tanah Datar Regency. Researchers found that there are several functions of the Sumatra Volunteer Foundation 1). Improving children's education 2). Empowering the community 3). Designing or producing products that have selling value 4). Waste Bank 5). Environmental care activities. The impact caused by the existence of the Sumatra Volunteer Foundation is, 1). Character building 2). Improve the ability to speak English, 3). Concern for the environment, 4). Open insight.
INFLUENCE OF OBESITY ON DIFFICULTY OF RUNNING CORONAVIRUS DISEASE (COVID-19) (clinical case)
Authors: Moskaliuk V.D. , Boiko Yu.I. , Kolotylo T.R. , Chernetska N.V. 
Published: January 2024

Aim: To conduct a retrospective analysis of the influence of obesity on the severity of the course of COVID-19 based on the analysis of the chart of an inpatient who was treated in the infectious department of the Chernivtsi Regional Clinical Hospital.
Materials and methods. "Medical card of an inpatient" of a patient who was undergoing inpatient treatment in the infectious department of the Chernivtsi Regional Clinical Hospital.
Results. A 42-year-old obese patient (BMI 40.0 kg/m2) was admitted to the inpatient ward of the infectious disease department of the Chernivtsi Regional Clinical Hospital on the 5th day of her illness. In hospital conditions, oxygen therapy was immediately started (flow 3 l/min), antibiotic therapy (cefepime - 1 g 3 r/day), hormone therapy (dexamethasone - 8 mg 1 r/day) was prescribed. On the 26th day of intensive treatment, the patient's condition significantly worsened. The state of consciousness was disturbed to the level of sopor, and then came a coma. Hemodynamic instability was noted, which required medical support (dopamine). The patient underwent endotracheal intubation and mechanical ventilation. Despite all the measures applied, cardiac arrest occurred. The resuscitation measures that were carried out did not have the desired effect, and the death of the patient was confirmed.
Conclusion. In patients with obesity (BMI > 40), the course of COVID-19 is much more severe, compared to patients whose body weight is within acceptable norms. Also, excess body weight significantly increases the risk of complications in patients with COVID-19 caused by Sars-Cov2, and more often leads to a fatal outcome.
MORPHOLOGICAL FEATURES OF THE LIVER AND CONDITION OF THE MICROCIRCULATORY BED AFTER EXPERIMENTAL APPLICATION OF CANNABIDIOL OIL
Authors: Shevchuk M.M. , Volos L.I. 
Published: January 2024

Background. Cannabidiol (CBD) is a natural non-psychoactive phytocannabinoid found in ordinary hemp. There has been a significant increase in the use of CBD in recent years with potential therapeutic effects, however, most of which have been documented in clinical trials and some with questionable results. Of particular concern is the possible risk of hepatotoxicity caused by CBD, therefore, additional experimental studies are needed to research the chronic effects of low doses of CBD, features of pathohistological changes in the liver, with an emphasis on the levels of possible damage to liver vessels, features of hemodynamics, at the level of the microcirculatory bed.
Aim: to investigate the histological features of liver changes and the condition of the microcirculatory bed after 4 weeks of experimental application cannabidiol oil.
Materials and methods. The research was conducted on white male rats, weighing 180-230 g, aged 5-7 months at the beginning of the experiment. The rats were kept in standard vivarium conditions, the main group consisted of 18 rats, which were given 5 drops (3 mg) of 10% cannabidiol oil daily for 4 weeks in the main feed, 6 rats – the intact group. All experiments were conducted in accordance with international rules for humane treatment of animals. Collection of biological material was carried out after euthanasia using diethyl ether. A histological and immunohistochemical study of the liver and blood vessels was performed to determine the effect of 10% cannabidiol oil.
Results. Based on the conducted histological and immunohistochemical research, it was established that the use of 10% CBD oil as a food supplement for 4 weeks did not cause acute or chronic liver damage. No violations of the lobular structure were detected, the histological structure and morphometric parameters of the components of the vascular bed, in particular arterial vessels, portal, venous and lymphatic vessels, sinusoids, bile ducts and cells of the connective tissue stroma of the liver, did not differ from the control group.
Conclusion. Given the lack of adverse effects after four weeks use of 10% CBD oil on the parenchymal and stromal components of the liver, more research is needed of other time points to determine possible adverse effects on the liver, assess risk factors, and outcomes to potentially determine optimal human medical drugs with CBD oil use.
EFFLUX PUMPS AS A PHARMACOLOGICAL TARGET TO COMBAT ANTIBIOTIC RESISTANCE
Authors: Khaitovych M.V. 
Published: January 2024

Backround. Antibiotic resistance is the resistance of bacteria to antimicrobial drugs to which they were previously sensitive. A particular danger is the spread of multidrug-resistant healthcare-associated infections of "ESKAPE" group. Among the mechanisms of antibiotic resistance of these bacteria, the activation of efflux pumps attracts special attention.
Aim: to review the current data on the possibility of using efflux pumps as targets for pharmacological action to overcome antibiotic resistance.
Materials and methods. Analysis of the data presented in PubMed by keywords "antimicrobial resistance", "efflux pumps", "efflux pump inhibitors".
Results. Multidrug efflux pumps are transmembrane transporter proteins that are located in the bacterial cell membrane and periplasm, they are naturally expressed, removing most of the clinically relevant antibiotic from the internal environment of the cell to the external environment, reducing its intracellular concentration. It is promising to combine certain antibiotics with efflux pump inhibitors, this allows to reduce the therapeutic dose of antibiotics and prevent the formation of bacterial biofilms. Data on the study of the effectiveness of well-known drugs sertraline, trimethoprim, thioridazine, diclofenac sodium, ibuprofen, nitroglycerin, metformin, and verapamil as efflux pump inhibitors are presented. The use of compounds obtained from plants (for example, berberine, artesunate and curcumin inhibit the activity of the efflux pump of gram-negative bacilli E. coli and P. aeruginosa), vegetables (in particular, Momordica balsamina), seeds of thistle, pepper, cumin, essential oils, etc. is promising.
Conclusion. Thus, inhibition of efflux pumps may be a potential way to improve antibiotic activity. The advantage of efflux pumps inhibitors is the difficulty of developing resistance against them in bacteria. It is advisable to conduct in vivo studies to confirm their activity and clinical effectiveness.
EXPERIENCE OF USING OPTICAL COHERENCE TOMOGRAPHY IN CORNEAL INJURIES
Authors: Gavrylyak I. V. , Zhaboiedov D. G. , Greben N. K. 
Published: January 2024

Background. Eye trauma is one of the most common causes of monocular visual impairment and blindness worldwide. Modern classification divides eye trauma into two groups: open (penetrating) and closed (non-penetrating) eye trauma. During the diagnostic phase, it is important to thoroughly examine and establish the correct diagnosis according to the existing classification, which affects the further patient management and treatment outcomes. Optical coherence tomography (OCT) allows for real-time imaging of eye tissues with high resolution. In our study, we present our experience in using optical coherence tomography in cases of traumatic corneal injuries as an additional method for assessing the depth and extent of damage and monitoring corneal erosion healing.
Aim. To utilize optical coherence tomography of the anterior segment of the eye for the diagnosis and assessment of corneal wound healing processes.
Materials and Methods. The research involved 46 patients with non-penetrating corneal injuries who were observed at the clinics of Bogomolets National Medical University. A control group consisting of 15 healthy patients was also included in the study. Data collection included patient demographic information, occupation, mechanism and duration of the trauma, the presence of recurrences, and the period of seeking medical assistance. All patients underwent visual acuity assessment, biomicroscopy, evaluation of the conjunctiva and corneal condition, and fluorescein testing. Using Optical Coherence Tomography (OCT) of the anterior segment, we monitored corneal thickness and the size of the epithelial defect before and after treatment.
Results. In optical coherence tomography of traumatic corneal erosion, in most cases, a defect in the epithelium of irregular shape with uneven edges, an irregular mixed anterior surface of the stroma, non-uniform reflectivity of the stroma, and corneal thinning were visualized. After treatment, the results corresponded to corneal epithelialization: thick intact epithelium, hyperreflective stroma, and a demarcation line confirming the wound healing process. After treatment, the corneal thickness was restored to (529 ± 144 μm), which is comparable to the thickness of a healthy cornea.
Conclusion. Optical Coherence Tomography (OCT) is an informative supplementary diagnostic method for corneal injuries, allowing for the assessment of corneal morphology, including the condition of the basal membrane, corneal thickness, and epithelialization. Based on these findings, we can predict the course of corneal trauma and its potential consequences, enabling us to adjust treatment strategies to prevent the development of fibrosis and minimize the long-term effects of the injury.
Analysis of risks in stock management, storage and transportation of vaccines to health care institutions
Authors: Салій О. О. , Тарасенко Г. В. , Шовкова О. Ю. , Куришко Г. Г. 
Published: January 2024

Infectious diseases remain one of the main causes of population mortality around the world, therefore the circulation, control over the quality and safety of vaccines in almost all countries is under special state control and is carried out separately from other pharmaceuticals. The quality of vaccines and the effectiveness of the population vaccination process largely depend on compliance with the requirements regarding the temperature regime, which must be flawlessly fulfilled by all participants in the pharmaceutical supply chain – the vaccine manufacturer, transporter, distributor, pharmacy or health care institution, the final consumer of vaccines (patient).
The purpose of the work is to identify the risks present in the vaccine supply chain, in the management of stocks, storage and transportation of vaccines to health care facilities, as well as to investigate the priority of these risks in the supply chain of the COVID-19 vaccine.
The assessment of industry risks in the provision of vaccines against COVID-19 to health care facilities was carried out using the method of analyzing the types, consequences and criticality of failures (FMECA) with the accepted quantitative values of the assessment of the severity of consequences (S), the probability of occurrence (О) and the possibility of detection (D). The quantitative assessment of the risk value (R) was carried out according to the priority value of the RPN risk level. Identification of specific risks was carried out by the method of expert assessments. The method of data collection is a questionnaire.
Categories of general, industry and specific risks were defined. It was established that general risks arise at the national level of risks, and their prevention is in the sphere of public administration. The results of the general assessment of industry risks by the FMECA method indicate that the risk of unfair distribution of vaccines is one of the essential ones for stopping the pandemic and unnecessary deaths of the population (RPN = 40). According to the results of the questionnaire of the expert group, the most critical specific risk was the risk of virus variability (19% of the determined sample).
The obtained data indicate that the priority direction of reducing risks in the management of stocks, storage and transportation of vaccines to health care institutions is the implementation of state programs for building up own capacities for the production of vaccines.
Use of chemoinformatics and bioinformatics databases in the processes of computer-aided drug design (review)
Authors: Кленіна О. В. , Чабан Т. І. 
Published: January 2024

The introduction of molecular modeling methods into the computer-aided drug discovery (CADD) process allows to minimize the time and costs for construction and development of new biologically active substances in comparison with traditional experimental approaches. In silico drug development process includes the identification of potential biological targets for drug candidates and the combinatorial libraries creation of low molecular weight compounds followed by their virtual screening to selected macromolecules. This approach becomes possible due to the availability of information about the three-dimensional chemical structures of ligands and biomolecules. In this context, freely available chemoinformatics and bioinformatics databases are the highly effective resources for use at various stages of the rational drug design process.
The aim of this review was to consider the main approaches towards the application of molecular modeling methods in the process of rational drug discovery, as well as to analyse and summarize information concerning modern chemoinformatics and bioinformatics databases, which are freely available and widely used at all stages of the search and development of potential drug candidates.
In the process of the review preparation we used a complex of general scientific methods of searching and systematizing literary references, analysis and comparison of information from various sources, generalization with the indication of development trends, selection of new and promising research directions.
This review also describes the main modern freely available chemoinformatics and bioinformatics databases. These information resources are widely used for ligand-based and receptor-based virtual screening, which are the main approaches in the process of computer-aided drag design.
Successes in the development of organic synthesis, high-throughput screening, experimental biology, chemistry, and medicine, as well as the development and implementation of new approaches and tools in chemoinformatics and bioinformatics, Big Data and information technologies achievements have created the basis for the development and increasing updating of highly efficient and curated databases. Freely available chemoinformatics and bioinformatics database resources are widely used in the processes of in silico discovery and improvement of potential drug candidate.
ПЕДАГОГІКА ЗДОРОВ'Я І ЗДОРОВ'ЯЗБЕРІГАЮЧИЙ ПОТЕНЦІАЛ ОСОБИСТОСТІ
Authors: Цибулько Людмила , Чорний Сергій , Бойченко Артем 
Published: January 2024

У статті розкривається сутність педагогіки здоров’я та здоров'язберігаючого потенціалу особистості як інтегрованого поняття, що відбиває певну життєву позицію людини, спрямовану на збереження і зміцнення здоров'я та засноване на виконанні норм, правил і вимог особистої та загальної гігієни; визначаються напрями педагогіки здоров'я, що сприяють збереженню та розвитку здоров'я підростаючого покоління: фізкультурно-оздоровче – збереження та розвиток здоров'я дітей, підлітків та юнацтва засобами фізичної культури; лікувально-реабілітаційне (оздоровлення дитячого населення за допомогою фізіо-, фіто-, фармако-, психотерапевтичних заходів та лікувальної фізкультури; гігієно-профілактичне збереження здоров'я учнів через раціональну організацію навчальної діяльності; еколого-зберігаючий розвиток здоров'я при формуванні екологічно доцільного навчально-виховного навчання, організації діяльності здобувачів освіти щодо збереження та розвитку здоров'я за допомогою актуалізації їх особистісного зростання, розвитку рефлексивних здібностей, ціннісного сенсу життєдіяльності, умінь приймати відповідальні рішення за власне здоров'я; забезпечення безпеки життєдіяльності (навчання учнів у ситуаціях, зумовлених природними, техногенними та побутовими факторами); конфесійне - виховання здорової особистості з пріоритетом розвитку духовного життя людини.
Робиться висновок, що в процесі цілеспрямованого розвитку здоров'язберігаючого потенціалу у майбутніх фахівців з фізичної культури відбувається стимулювання усвідомлення здоров'я як особистісної цінності, тобто наявність ціннісного ставлення до здоров'я, розуміння культури здоров'я як складової загальної культури особистості та прагнення здорового способу життя. Розвиток здоров'язберігаючого потенціалу здобувачів освіти має бути однією з основних складових освітнього процесу сучасного закладу освіти, а суспільство, яке прагне жити в гармонії із довкіллям, має не лише декларувати, а й формувати систему цінностей здоров’я у кожного громадянина України.
Prevalencia de rotavirus, adenovirus y enteroparásitos en niños procedentes de una zona de altitud de Los Andes ecuatorianos
Authors: Monar Basantes Silvia Paola , González Ramírez Luisa Carolina , Cedeño Cajas Gisnella María , Jacome Lara Luis Jhair 
Published: January 2024

Introducción. Las infecciones intestinales causadas por Rotavirus, Adenovirus y parásitos es uno de los problemas de salud que más afecta a la población infantil menores de 6 años ocasionando una elevada morbilidad y mortalidad a escala mundial. Objetivo. Conocer la prevalencia de Rotavirus, Adenovirus y enteropárasitos en niños procedentes de Los Andes ecuatorianos. Metodología. La investigación fue de tipo cuantitativo, no experimental, descriptivo, analítico, de campo, prospectivo y de corte transversal. El tamaño de la muestra se determinó aplicando la fórmula de población finita, se realizó un muestreo probabilístico. Se recolectaron 386 muestras de pacientes pediátricos entre 6 meses y 6 años de edad. Para la detección de Rotavius y Adenovirus se utilizó el inmunoensayo cromatográfico Simple Rota-Adeno (Operon®). Las muestras fecales fueron analizadas mediante examen macroscópico y microscópico con solución salina fisiológica/solución yodada Resultados. Se detectaron antígenos virales en 128/386 (33,16%) muestras de heces. La prevalencia de Rotavirus (22,28%) fue mayor que la de Adenovirus (10,88%) (X2= 18,131 p<0,0001). La tasa de antígenos de Rotavirus fue mayor para niños entre 6 meses y 3 años (44,06%) que la detectada en niños entre 4 y 6 años (21,20%)(X2= 22,710 p<0,0001), . Además, el parasitismo total alcanzó 88,60%, los protozoos (88,60%) (X2=651,826 p<0,0001), siendo Entamoeba coli el parásito predominante (43,78%) (X2= 481,088 p<0,0001), seguido de Blastocystis sp. (36,53%). Se destaca la prevalencia de los parásitos de reconocida patogenicidad como Giardia duodenalis (14,77%), Ascaris lumbricoides e Hymenolepis nana (0,52%). Conclusión. La prevalencia de los agentes virales y enteroparásitos en la población pediátrica analizada es considerable, Rotavirus fue el patógeno más frecuente en los niños de menor edad. El hallazgo de los mismos agentes virales y especies parasitarias detectadas obliga a revisar las políticas de salud pública dirigidas a reducir la frecuencia de enfermedades diarreicas causadas por estos virus y parásitos intestinales en nuestra población infantil.
Factores asociados a la tendinopatía del manguito rotador y tratamientos fisioterapéuticos. Revisión corta
Authors: Ustáriz Fajardo Francisco Javier , Álvarez Carrión Sonia Alexandra , Pérez García María Belén , Cáceres Manzano Verónica Paulina 
Published: January 2024

Introducción. La tendinopatía es un problema clínico común y conlleva una importante carga de enfermedad, no solo en términos de costos de atención médica, sino también directamente para los pacientes por el tiempo de baja laboral e impacto en la calidad de vida. La tendinopatía es un espectro multifactorial de trastornos de los tendones que afecta a diferentes sitios anatómicos y se caracteriza por dolor tendinoso relacionado con la actividad; entre ellas la tendinopatía del manguito rotador como causa recurrente común de dolor en el hombro en deportistas y población en envejecimiento. Objetivo. El presente trabajo tiene como finalidad describir los factores asociados a tendinopatía del manguito rotador, así como, las diferentes alternativas de tratamiento fisioterapéutico. Metodología. Este trabajo de investigación es tipo documental, retrospectivo y descriptivo fundamentado en la búsqueda de literatura en bases de datos en línea, según los ítems propuestos por Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), que incluyen la identificación, selección e inclusión de la literatura consultada. Resultados. La búsqueda permitió la consulta de artículos científicos obtenidos de ocho bases de datos en línea, publicados entre 2015-2023. Los estudios analizados describen múltiples factores asociados a las tendinopatías en general y la del manguito rotador en específico, así como también, las distintas opciones de tratamientos disponibles. Conclusión. El material bibliográfico consultado permitió establecer que la tendinopatía del manguito rotador es la patología más frecuente en hombro y causa recurrente común de dolor, donde factores extrínsecos e intrínsecos juegan un papel importante para su desarrollo e instauración. Situación ésta que ha generado el desarrollado de múltiples alternativas de tratamientos entre los que destacan los tratamientos conservadores, conocidos y aplicados en fisioterapia; no obstante, la comprensión incompleta de los mecanismos fisiopatológicos del tendón obstaculiza el desarrollo de terapias específicas, que sustenten su eficacia de forma definitiva.