bluuebunny/crossref_metadata_2025_split huggingface dataset:
H - 65 Clinical Evidence for an Age-Dependent Relationship between Kawasaki Disease and Cognition in a Latinx/e Girl
Authors: Oleas Denise , Weiss Erica , McGinley John , Bronshteyn Diana , Stimmel Marnina , Facchini Ronda 
Published: October 2023

Abstract

Objective
Kawasaki Disease (KD) is the leading cause of acquired heart disease in children in developed countries (e.g., Japan, U.S.). Rare in the U.S., the systemic, acute inflammation condition with typical symptoms of a fever, cervical lymphadenopathy, conjunctivitis, extremity changes, and exanthema, can cause long term post-inflammatory neurological and emotional changes. Cognitive deficits (e.g., ADHD) can emerge post-KD but the literature is equivocal and to-date there are no U.S. studies. We report the case of an 11-year-old Latinx/e girl to expand knowledge of KD-related cognitive changes.

Method
Comprehensive neuropsychological assessment of an 11-year-old with KD diagnosed in early childhood and hemiplegic migraines, academic difficulties and emotional intolerance.

Results
Overall ability was within the low average range with significant negative impact of slow processing speed. Academic assessment demonstrated moderate impairment in reading, and mild math impairment. Memory, expressive/receptive language, visuospatial, and psychomotor abilities were within expectation. Variable complex attention, impulsivity, inattention, and poor self-monitoring were evident. Mild anxiety was reported. Resulting diagnoses of ADHD, and Reading Disorder were offered.

Conclusions
KD may produce inflammation in the brain and neurological changes which may lead to later cognitive impairment. This 11-year-old Latinx/e girl’s cognitive profile supports recent literature suggesting KD-related cognitive difficulties likely develop between 5-10 yrs after KD diagnosis and reinforces the need for longitudinal research. Furthermore, it expands the literature regarding the neuropsychological effects of KD on cognitive functioning in Latinx/e children in the U.S as to date most research has focused on children of Asian-descent.
PGE2 functions in ovoviviparous teleost black rockfish (Sebastes schlegelii): evolutionary status between parturition and ovulation
Authors: Lyu Likang , Wen Haishen , Li Yun , Wang Xiaojie , Li Jianshuang , Zuo Chenpeng , Yan Shaojing , Qi Xin 
Published: October 2023

Abstract
Fish have evolved various reproductive strategies including oviparity, viviparity, and ovoviviparity, which undoubtedly affect the survival of the whole species continuity. As the final step in reproduction, parturition in viviparous vertebrate and ovulation in oviparous teleost seem to share a similar mechanism, when prostaglandins (PGs) act as the trigger to launch the whole process. In the present study, ovoviviparous teleost black rockfish (Sebastes schlegelii) is employed as the research object. Intraperitoneal injection showed that PGE2 (500 μg/kg) could activate the delivery reactions in perinatal black rockfish. RNA-seq data of ovary in perinatal period revealed transcriptional change in cell junction, inflammation, and apoptosis, which is related to mammal parturition and teleost ovulation. Further results proved the positive correlation between ptger EP2 and previous mentioned pathways. Subsequent experiment proved that PGE2 was able to induce the ovulation and spawning in unfertilized individuals, which had a bilayer follicular structure compared to monolayer follicular in perinatal period black rockfish. Both unfertilized and perinatal ovary matrix could response to PGE2 stimulation. In conclusion, the function of PGE2 in activating both parturition and ovulation in a relatively different pathways conserved with viviparity or oviparity provided novel evidence of the evolutionary status of ovoviviparous vertebrates.
Improved fMRI-based pain prediction using Bayesian group-wise functional registration
Authors: Wang Guoqing , Datta Abhirup , Lindquist Martin A 
Published: October 2023

Summary
In recent years, the field of neuroimaging has undergone a paradigm shift, moving away from the traditional brain mapping approach towards the development of integrated, multivariate brain models that can predict categories of mental events. However, large interindividual differences in both brain anatomy and functional localization after standard anatomical alignment remain a major limitation in performing this type of analysis, as it leads to feature misalignment across subjects in subsequent predictive models. This article addresses this problem by developing and validating a new computational technique for reducing misalignment across individuals in functional brain systems by spatially transforming each subject’s functional data to a common latent template map. Our proposed Bayesian functional group-wise registration approach allows us to assess differences in brain function across subjects and individual differences in activation topology. We achieve the probabilistic registration with inverse-consistency by utilizing the generalized Bayes framework with a loss function for the symmetric group-wise registration. It models the latent template with a Gaussian process, which helps capture spatial features in the template, producing a more precise estimation. We evaluate the method in simulation studies and apply it to data from an fMRI study of thermal pain, with the goal of using functional brain activity to predict physical pain. We find that the proposed approach allows for improved prediction of reported pain scores over conventional approaches.
Received on 2 January 2017. Editorial decision on 8 June 2021
Gathering Over Heterogeneous Meeting Nodes
Authors: Chakraborty Abhinav , Bhagat Subhash , Mukhopadhyaya Krishnendu 
Published: October 2023

Abstract
We consider two finite and disjoint sets of homogeneous robots deployed at the nodes of an infinite grid graph. The grid graph also comprises two finite and disjoint sets of prefixed meeting nodes located over the nodes of the grid. The objective of our study is to design a distributed algorithm that gathers all the robots belonging to the first team at one of the meeting nodes belonging to the first type, and all the robots in the second team must gather at one of the meeting nodes belonging to the second type. The robots can distinguish between the two types of meeting nodes. However, a robot cannot identify its team members. This paper assumes the strongest adversarial model, namely the asynchronous scheduler. We have characterized all the initial configurations for which the gathering problem is unsolvable. For the remaining initial configurations, the paper proposes a distributed gathering algorithm. Assuming the robots are capable of global-weak multiplicity detection, the proposed algorithm solves the problem within a finite time period. The algorithm runs in $\Theta (dn)$ moves and $O(dn)$ epochs, where $d$ is the diameter of the minimum enclosing rectangle of all the robots and meeting nodes in the initial configuration, and $n$ is the total number of robots in the system.
Coronary calcification in patients presenting with acute coronary syndromes: insights from the MATRIX trial
Authors: Sanz-Sanchez Jorge , Garcia-Garcia Hector M , Branca Mattia , Frigoli Enrico , Leonardi Sergio , Gagnor Andrea , Calabrò Paolo , Garducci Stefano , Rubartelli Paolo , Briguori Carlo , Andò Giuseppe , Repetto Alessandra , Limbruno Ugo , Garbo Roberto , Sganzerla Paolo , Russo Filippo , Lupi Alessandro , Cortese Bernardo , Ausiello Arturo , Ierna Salvatore , Esposito Giovanni , Santarelli Andrea , Sardella Gennaro , Varbella Fernando , Tresoldi Simone , de Cesare Nicoletta , Rigattieri Stefano , Zingarelli Antonio , Tosi Paolo , van ‘t Hof Arnoud , Boccuzzi Giacomo , Omerovic Elmir , Sabaté Manel , Heg Dik , Vranckx Pascal , Valgimigli Marco 
Published: October 2023

Abstract

Aims
The role of coronary calcification on clinical outcomes among different revascularization strategies in patients presenting with acute coronary syndromes (ACSs) has been rarely investigated. The aim of this investigation is to evaluate the role of coronary calcification, detected by coronary angiography, in the whole spectrum of patients presenting with acute ACS.

Methods and results
The present study was a post hoc analysis of the MATRIX programme. The primary endpoint was major adverse cardiovascular events (MACE), defined as the composite of all-cause mortality, myocardial infarction (MI), or stroke up to 365 days. Among the 8404 patients randomized in the MATRIX trial, data about coronary calcification were available in 7446 (88.6%) and therefore were included in this post hoc analysis. Overall, 875 patients (11.7%) presented with severe coronary calcification, while 6571 patients (88.3%) did not present severe coronary calcification on coronary angiography. Fewer patients with severe coronary calcification underwent percutaneous coronary intervention whereas coronary artery bypass grafting or medical therapy-only was more frequent compared with patients without severe calcification. At 1-year follow-up, MACE occurred in 237 (27.1%) patients with severe calcified coronary lesions and 985 (15%) patients without severe coronary calcified lesions [hazard ratio (HR) 1.91; 95% confidence interval (CI) 1.66–2.20, P &lt; 0.001]. All-cause mortality was 8.6% in patients presenting with and 3.7% in those without severe coronary calcification (HR 2.38, 1.84–3.09, P &lt; 0.001). Patients with severe coronary calcification incurred higher rate of MI (20.1% vs. 11.5%, HR 1.81; 95% CI 1.53–2.1, P &lt; 0.001) and similar rate of stroke (0.8% vs. 0.6%, HR 1.35; 95% CI 0.61–3.02, P = 0.46).

Conclusion
Patients with ACS and severe coronary calcification, as compared to those without, are associated with worse clinical outcomes irrespective of the management strategy.
Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics
Authors: Stampe Niels Kjær , Ottenheijm Maud Eline , Drici Lylia , Wewer Albrechtsen Nicolai J , Nielsen Annelaura Bach , Christoffersen Christina , Warming Peder Emil , Engstrøm Thomas , Winkel Bo Gregers , Jabbari Reza , Tfelt-Hansen Jacob , Glinge Charlotte 
Published: October 2023

Abstract

Aims
The underlying biological mechanisms of ventricular fibrillation (VF) during acute myocardial infarction are largely unknown. To our knowledge, this is the first proteomic study for this trait, with the aim to identify and characterize proteins that are associated with VF during first ST-elevation myocardial infarction (STEMI).

Methods and results
We included 230 participants from a Danish ongoing case-control study on patients with first STEMI with VF (case, n = 110) and without VF (control, n = 120) before guided catheter insertion for primary percutaneous coronary intervention. The plasma proteome was investigated using mass spectrometry-based proteomics on plasma samples collected within 24 h of symptom onset, and one patient was excluded in quality control. In 229 STEMI patients {72% men, median age 62 years [interquartile range (IQR): 54–70]}, a median of 257 proteins (IQR: 244–281) were quantified per patient. A total of 26 proteins were associated with VF; these proteins were involved in several biological processes including blood coagulation, haemostasis, and immunity. After correcting for multiple testing, two up-regulated proteins remained significantly associated with VF, actin beta-like 2 [ACTBL2, fold change (FC) 2.25, P &lt; 0.001, q = 0.023], and coagulation factor XIII-A (F13A1, FC 1.48, P &lt; 0.001, q = 0.023). None of the proteins were correlated with anterior infarct location.

Conclusion
Ventricular fibrillation due to first STEMI was significantly associated with two up-regulated proteins (ACTBL2 and F13A1), suggesting that they may represent novel underlying molecular VF mechanisms. Further research is needed to determine whether these proteins are predictive biomarkers or acute phase response proteins to VF during acute ischaemia.
Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease – a cross-sectional study
Authors: Sævik Åse Bjorvatn , Ueland Grethe , Åkerman Anna-Karin , Methlie Paal , Quinkler Marcus , Jørgensen Anders Palmstrøm , Höybye Charlotte , Debowska Aleksandra W J , Nedrebø Bjørn Gunnar , Dahle Anne Lise , Carlsen Siri , Tomkowicz Aneta , Sollid Stina Therese , Nermoen Ingrid , Grønning Kaja , Dahlqvist Per , Grimnes Guri , Skov Jakob , Finnes Trine , Valland Susanna F , Wahlberg Jeanette , Holte Synnøve Emblem , Kämpe Olle , Bensing Sophie , Husebye Eystein Sverre , Øksnes Marianne 
Published: October 2023

Abstract

Objective
Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood.

Design
Cross-sectional study.

Methods
We compared serum levels of 177 cardiovascular and inflammatory biomarkers in 43 patients with AAD at &gt;18-h glucocorticoid withdrawal and 43 matched controls, overall and stratified for sex. Biomarker levels were correlated with the frequency of adrenal crises and quality of life (QoL) by AddiQoL-30. Finally, we investigated changes in biomarker levels following 250 µg tetracosactide injection in patients without residual adrenocortical function (RAF) to explore glucocorticoid-independent effects of high ACTH.

Results
Nineteen biomarkers significantly differed between patients with AAD and controls; all but 1 (ST1A1) were higher in AAD. Eight biomarkers were significantly higher in female patients compared with controls (IL6, MCP1, GAL9, SPON2, DR4, RAGE, TNFRSF9, and PGF), but none differed between male patients and controls. Levels of RAGE correlated with the frequency of adrenal crises (r = 0.415, P = .006) and AddiQoL-30 scores (r = −0.347, P = .028) but not after correction for multiple testing. PDL2 and leptin significantly declined 60 min after injection of ACTH in AAD without RAF (−0.15 normalized protein expression [NPX], P = .0001, and −0.25 NPX, P = .0003, respectively).

Conclusions
We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.
Ceauşescu, Barthes and a Few Boring Hippies: May and August 1968 in Romania
Authors: Matei Alexandru 
Published: October 2023

ABSTRACT
This article offers an overview of the Romanian echoes of the French social turbulence of May 68. It also explains the conservatism of Romanian cultural and political institutions at that moment. The article addresses the question of why Nicolae Ceaușescu’s nationalist communist regime prevented Romanian May 68 upheavals from taking place. It argues that the events of May 1968 cannot be separated from August 1968 (the Soviet invasion of Czechoslovakia) and from the two previous decades of Soviet control over Romanian culture. In such a context, nationalism was perceived as an emancipation compared to the previous Stalinist era, and any favourable echo of the French 1968 social movements would have challenged it. The article argues that the view of Romania’s 1968 that emerges in periodicals challenges the perspective that May 68 represented youthful revolt against capitalist systems. Instead, a more nuanced picture is required, one that is specific to Romania at that time.
Variation in transcription regulator expression underlies differences in white–opaque switching between the SC5314 reference strain and the majority of Candida albicans clinical isolates
Authors: Lohse Matthew B , Ziv Naomi , Johnson Alexander D 
Published: October 2023

Abstract
Candida albicans, a normal member of the human microbiome and an opportunistic fungal pathogen, undergoes several morphological transitions. One of these transitions is white–opaque switching, where C. albicans alternates between 2 stable cell types with distinct cellular and colony morphologies, metabolic preferences, mating abilities, and interactions with the innate immune system. White-to-opaque switching is regulated by mating type; it is repressed by the a1/α2 heterodimer in a/α cells, but this repression is lifted in a/a and α/α mating type cells (each of which are missing half of the repressor). The widely used C. albicans reference strain, SC5314, is unusual in that white–opaque switching is completely blocked when the cells are a/α; in contrast, most other C. albicans a/α strains can undergo white–opaque switching at an observable level. In this paper, we uncover the reason for this difference. We show that, in addition to repression by the a1/α2 heterodimer, SC5314 contains a second block to white–opaque switching: 4 transcription regulators of filamentous growth are upregulated in this strain and collectively suppress white–opaque switching. This second block is missing in the majority of clinical strains, and, although they still contain the a1/α2 heterodimer repressor, they exhibit a/α white–opaque switching at an observable level. When both blocks are absent, white–opaque switching occurs at very high levels. This work shows that white–opaque switching remains intact across a broad group of clinical strains, but the precise way it is regulated and therefore the frequency at which it occurs varies from strain to strain.
Cefiderocol use for the treatment of infections by carbapenem-resistant Gram-negative bacteria: an Italian multicentre real-life experience
Authors: Piccica Matteo , Spinicci Michele , Botta Annarita , Bianco Vincenzo , Lagi Filippo , Graziani Lucia , Faragona Alessandro , Parrella Roberto , Giani Tommaso , Bartolini Andrea , Morroni Gianluca , Bernardo Mariano , Rossolini Gian Maria , Tavio Marcello , Giacometti Andrea , Bartoloni Alessandro 
Published: October 2023

Abstract

Background
Cefiderocol is a novel siderophore cephalosporin with promising activity against most carbapenem-resistant Gram-negative bacteria (CRGNB). However, extensive postmarketing experiences are lacking. This study aimed to analyse the early experience on cefiderocol postmarketing use at three tertiary care hospitals in Italy.

Methods
We retrospectively included patients with infections caused by CRGNB treated with cefiderocol at three Italian tertiary care hospitals from 1 March 2021 to 30 June 2022. A multivariate Cox model was used to identify predictors of 30 day mortality. A propensity score (PS) analysis with inverse probability weighting (IPW) was also performed to compare the treatment effect of cefiderocol monotherapy (CM) versus combination regimens (CCRs).

Results
The cohort included 142 patients (72% male, median age 67 years, with 89 cases of Acinetobacter baumannii infection, 22 cases of Klebsiella pneumoniae, 27 cases of Pseudomonas aeruginosa and 4 of other pathogens). The 30 day all-cause mortality was 37% (52/142). We found no association between bacterial species and mortality. In multivariate analysis, a Charlson Comorbidity Index &gt;3 was an independent predictor of mortality (HR 5.02, 95% CI 2.37–10.66, P &lt; 0.001). In contrast, polymicrobial infection (HR 0.41, 95% CI 0.21–0.82, P &lt; 0.05) was associated with lower mortality. There was no significant difference in mortality between patients receiving CM (n = 70) and those receiving a CCR (n = 72) (33% versus 40%, respectively), even when adjusted for IPW-PS (HR 1.11, 95% CI 0.63–1.96, P = 0.71).

Conclusions
Real-life data confirm that cefiderocol is a promising option against carbapenem-resistant Gram-negative infections, even as monotherapy.
The role of health system penetration rate in estimating the prevalence of type 1 diabetes in children and adolescents using electronic health records
Authors: Li Piaopiao , Lyu Tianchen , Alkhuzam Khalid , Spector Eliot , Donahoo William T , Bost Sarah , Wu Yonghui , Hogan William R , Prosperi Mattia , Schatz Desmond A , Atkinson Mark A , Haller Michael J , Shenkman Elizabeth A , Guo Yi , Bian Jiang , Shao Hui 
Published: October 2023

Abstract

Objective
Having sufficient population coverage from the electronic health records (EHRs)-connected health system is essential for building a comprehensive EHR-based diabetes surveillance system. This study aimed to establish an EHR-based type 1 diabetes (T1D) surveillance system for children and adolescents across racial and ethnic groups by identifying the minimum population coverage from EHR-connected health systems to accurately estimate T1D prevalence.

Materials and methods
We conducted a retrospective, cross-sectional analysis involving children and adolescents &lt;20 years old identified from the OneFlorida+ Clinical Research Network (2018-2020). T1D cases were identified using a previously validated computable phenotyping algorithm. The T1D prevalence for each ZIP Code Tabulation Area (ZCTA, 5 digits), defined as the number of T1D cases divided by the total number of residents in the corresponding ZCTA, was calculated. Population coverage for each ZCTA was measured using observed health system penetration rates (HSPR), which was calculated as the ratio of residents in the corresponding ZTCA and captured by OneFlorida+ to the overall population in the same ZCTA reported by the Census. We used a recursive partitioning algorithm to identify the minimum required observed HSPR to estimate T1D prevalence and compare our estimate with the reported T1D prevalence from the SEARCH study.

Results
Observed HSPRs of 55%, 55%, and 60% were identified as the minimum thresholds for the non-Hispanic White, non-Hispanic Black, and Hispanic populations. The estimated T1D prevalence for non-Hispanic White and non-Hispanic Black were 2.87 and 2.29 per 1000 youth, which are comparable to the reference study’s estimation. The estimated prevalence of T1D for Hispanics (2.76 per 1000 youth) was higher than the reference study’s estimation (1.48-1.64 per 1000 youth). The standardized T1D prevalence in the overall Florida population was 2.81 per 1000 youth in 2019.

Conclusion
Our study provides a method to estimate T1D prevalence in children and adolescents using EHRs and reports the estimated HSPRs and prevalence of T1D for different race and ethnicity groups to facilitate EHR-based diabetes surveillance.
Determination of Lactose in Lactose-Free and Low-Lactose Milk, Milk Products, and Products Containing Dairy Ingredients by the LactoSens®R Amperometry Method: Final Action 2020.01
Authors: Halbmayr-Jech Elisabeth , Kittl Roman , Weinmann Patrick , Schulz Christopher , Kowalik Anna , König Matthias , Korp Jasmin , Sygmund Christoph , Brunelle Sharon L 
Published: October 2023

Abstract

Background
The LactoSens®R method was previously shown to have acceptable accuracy and repeatability precision as required by AOAC Standard Method Performance Requirements (SMPR®) 2018.009 for determination of lactose in low-lactose or lactose-free milk, milk products, and products containing dairy ingredients and was awarded Official Method of AnalysisSM (OMA) First Action status in 2020.

Objective
The method was subjected to a multilaboratory validation (MLV) study to evaluate the reproducibility precision of the method.

Methods
Fourteen validation materials were provided to 15 laboratories in seven countries as blind duplicates. The materials ranged from 0 to 173 mg/100 g lactose. Each laboratory analyzed the blind duplicates according to OMA 2020.01. The data were analyzed for repeatability and reproducibility precision.

Results
RSDr values varied from 2.81 to 8.76%, and RSDR values varied from 4.25 to 12.5%. When sorted by category and concentration range, these results met the repeatability and reproducibility criteria required by SMPR 2018.009.

Conclusions
The data generated in the MLV support the adoption of OMA 2020.01 as Final Action status.

Highlights
The LactoSensR method, as described by OMA 2020.01, provides an accurate and precise determination of lactose in a variety of low-lactose and lactose-free milk, milk products, and products containing dairy ingredients in minutes.