bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Novel Marine Bioactive Compound as Potential Multiple Inhibitors in Triple-negative Breast Cancer - An in silico Approach
Authors: Manivannan Hema Priya , Veeraraghavan Vishnu Priya , Francis Arul Prakash 
Published: January 2024

Background:
Triple-negative breast cancer (TNBC) is a highly aggressive form of
breast cancer lacking specific receptors, with dysregulated and overactivated Hedgehog (Hh)
and mTOR/PI3K/AKT signaling pathways as potential therapeutic targets.

Objective:
This study aimed to identify potential inhibitors among 53 alkaloids derived from 9
marine bryozoans using in silico approaches. It sought to analyze their impact on key signaling
targets and their potential for future experimental validation.

Methods:
In this research, selected targets were evaluated for protein-protein interactions, coexpression
survival, and expression profiles. The protein expression was validated through the
Human Protein Atlas (HPA) database and druggability through DGIdb. Online web servers
were employed to assess drug-likeness, physiochemical properties, pharmacokinetics, and toxicological
characteristics of the compounds. Molecular docking and dynamic simulations were
carried out for ligand-protein interactions. Common Pharmacophore features, bioavailability,
bioactivity, and biological activity spectrum (BAS) were also analyzed.

method:
In this research, selected targets were evaluated for protein-protein interactions, co-expression survival, and expression profiles. The protein expression was validated through the Human Protein Atlas (HPA) database and druggability through DGIdb. Online web servers were employed to assess drug-likeness, physiochemical properties, pharmacokinetics, and toxicological characteristics of the compounds. Molecular docking and dynamic simulations were carried out for ligand-protein interactions. Common Pharmacophore features, bioavailability, bioactivity, and biological activity spectrum (BAS) were also analyzed.

Results:
Out of the 13 compounds studied, 10 displayed strong binding affinity with binding
energies ranging from >-6.5 to <-8 Kcal/mol across all targets. Molecular dynamics simulations
provided insights into Amathamide E's stability and conformational changes. Pharmacophore
modeling revealed common features in 14 compounds potentially responsible for their biological
activity.

result:
Out of the 13 compounds studied, 10 displayed strong binding affinity with binding energies ranging from &gt;-6.5 to &lt;-8 Kcal/mol across all targets. Molecular dynamics simulations provided insights into Amathamide E's stability and conformational changes. Pharmacophore modeling revealed common features in 14 compounds potentially responsible for their biological activity

Conclusion:
Our findings indicate the potential of marine-derived compounds as TNBC inhibitors.
Further in vitro and in vivo validation is necessary to establish their effectiveness and explore
their role as novel anti-TNBC agents.
GABA-transaminase: A Key Player and Potential Therapeutic Target for
Neurological Disorders
Authors: Grover Sania , Narang Raj Kumar , Singh Shamsher 
Published: January 2024

Abstract:
Neurological disorders such as epilepsy, autism, Huntington's disease, multiple sclerosis,
and Alzheimer's disease alter brain functions like cognition, mood, movements, and language, severely compromising the well-being of persons, suffering from their negative effects. The neurotransmitters (GABA, glutamate, norepinephrine, dopamine) are found to be involved in neuronal
signaling and neurotransmission. GABA, a "commanding neurotransmitter" is directly or indirectly
associated with various neurological disorders. GABA is metabolized to succinic semialdehyde by a
mitochondrial gamma-aminobutyric acid-transaminase (GABA-T) enzyme. Therefore, the alterations
in the GABA performance in the distinct regions of the brain via GABA-T overstimulation or inhibition would play a vital role in the pathogenesis of various neurological disorders. This review emphasizes the leading participation of GABA-T in neurological disorders like Huntington's disease,
epilepsy, autism, Alzheimer's disease, and multiple sclerosis. In Huntington's disease, epilepsy, and
multiple sclerosis, the surfeited performance of GABA-T results in diminished levels of GABA,
whereas in autism, the subsidence of GABA-T activity causes the elevation in GABA contents,
which is responsible for behavioral changes in these disorders. Therefore, GABA-T inhibitors (in
Huntington's disease, epilepsy, and multiple sclerosis) or agonists (in autism) can be used therapeutically. In the context of Alzheimer's disease, some researchers favor the stimulation of GABA-T activity whereas some disagree with it. Therefore, the activity of GABA-T concerning Alzheimer's
disease is still unclear. In this way, studies of GABA-T enzymatic activity in contrast to neurological
disorders could be undertaken to understand and be considered a therapeutic target for several
GABA-ergic CNS diseases.
Role of Imaging Genetics in Alzheimer’s Disease: A Systematic Review
and Current Update
Authors: Chhetri Aakash , Goel Kashish , Ludhiadch Abhilash , Singh Paramdeep , Munshi Anjana 
Published: January 2024

Background:
Alzheimer’s disease is a neurodegenerative disorder characterized by
severe cognitive, behavioral, and psychological symptoms, such as dementia, cognitive decline, apathy,
and depression. There are no accurate methods to diagnose the disease or proper therapeutic
interventions to treat AD. Therefore, there is a need for novel diagnostic methods and markers to
identify AD efficiently before its onset. Recently, there has been a rise in the use of imaging techniques
like Magnetic Resonance Imaging (MRI) and functional Magnetic Resonance Imaging
(fMRI) as diagnostic approaches in detecting the structural and functional changes in the brain,
which help in the early and accurate diagnosis of AD. In addition, these changes in the brain have
been reported to be affected by variations in genes involved in different pathways involved in the
pathophysiology of AD.

Methodology:
A literature review was carried out to identify studies that reported the association of
genetic variants with structural and functional changes in the brain in AD patients. Databases like
PubMed, Google Scholar, and Web of Science were accessed to retrieve relevant studies. Keywords
like ‘fMRI’, ‘Alzheimer’s’, ‘SNP’, and ‘imaging’ were used, and the studies were screened using
different inclusion and exclusion criteria.

Results:
15 studies that found an association of genetic variations with structural and functional
changes in the brain were retrieved from the literature. Based on this, 33 genes were identified to
play a role in the development of disease. These genes were mainly involved in neurogenesis, cell
proliferation, neural differentiation, inflammation and apoptosis. Few genes like FAS, TOM40,
APOE, TRIB3 and SIRT1 were found to have a high association with AD. In addition, other genes
that could be potential candidates were also identified.

Conclusion::
Imaging genetics is a powerful tool in diagnosing and predicting AD and has the
potential to identify genetic biomarkers and endophenotypes associated with the development of the
disorder.
Cucurbitaceae Glycoside: An In-depth Review on its Source, Structural,
and Medicinal Significance
Authors: Mulay Vallabh , Desikan Rajagopal 
Published: January 2024

Background:
The Cucurbitaceae family has been well-known since ancient times for
its use in daily food preparations. Various traditional medicinal systems have also recognized its
therapeutic importance. Its significance has also been established by modern techniques.

Objective:
The current review aims to emphasize the glycosides of the Cucurbitaceae family in
terms of their source, structures, extraction media, and bioactivities in various therapeutic areas
like anti-inflammatory, anti-bacterial, anti-cancerous, anti-diabetic, and cardiac models. Glycosides
of Cucurbitaceae have been studied extensively. However, considering the vastness of the
diversity among this family; there are still various avenues in which further research work is
needed.

Methods:
For the present review, we used Elsevier-ScienceDirect, SpringerLink, PubMed, ArticlesPlus,
Semantic Scholar, and Google Scholar to conduct a literature search.

Results:
Cucurbitaceae is enriched with secondary metabolites, mainly glycosides. The occurrence
of glycoside with its species, along with plant parts, is crucial and elaborately covered. It
also captures the extraction system. The structure of selected glycosides is represented along
with respective references. Various studies elaborate on the pharmacological significance of the
extracts in diverse therapeutic areas.

Conclusion:
This review provides extensive aspects about the glycosides of the family Cucurbitaceae
and will help in further exploration of extraction, isolation, and bioactivity studies of this
important class of compounds from one of the largest families, i.e., Cucurbitaceae. It reiterates the
need for further exploration in standardization along with extensive safety and efficacy studies.
Pharmacotherapy of Psychological Disorders Using Psychedelic Drugs: A Treatise for Psychiatrists
Authors: Ghosh Payal , Sur Debjeet 
Published: January 2024

:
Psychedelics are currently being examined once more as potential remedies
for untreatable biological illnesses after decades of research problems. They are frequently
regarded to be physically safe and do not frequently lead to dependency or addiction.
The use of psychedelic substances in the treatment of mental illness and the adoption of
the Substance Act of 1970 has classified psychedelic drugs as Schedule I. The major
objective of this review is to highlight the prospective use of specific psychedelic medicines,
such as psilocybin, LSD, MDMA, and ayahuasca, in the treatment of various psychiatric
conditions, such as treatment-resistant depression, post-traumatic traumatic
stress, end-of-life anxiety, and substance misuse disorders. As documented from both
animal and human studies, in addition, there will be a study of the effectiveness and safety.
The body of research suggests that psychedelics may one day offer revolutionary
treatments for mental diseases, contrary to conventional therapy. However, given their
distinctive histories and a high potential for abuse with widespread distribution, more
care and effort must be given to protect their use as efficient medical treatments instead
of drugs of abuse.
Capture of the Modification Effect of SBS-T Modifier on Asphalt and its Reasonable Mixing Process
Authors: Zhang Wengang , Yang Jixu , Shi Silin , Yan Xiang , Yang Jixiang , Liu Yichao , Cui Lilong 
Published: January 2024

Background:
The rationality of the mixing process specified in the "Technical
Guideline for Construction of Direct-to-Plant SBS Modified Bituminous Pavement"
needs further verification.

Objective:
To study the dynamic modification effect during the mixing process of
SBS-T and the optimal mixing process.

Method:
SBS-T-modified asphalt under different mixing processes was collected in
this paper, and the microscopic images were obtained by using fluorescence microscopy.
Then qualitative and quantitative analysis were conducted on the dynamic
modification effect. The pavement performances of SBS-T modified asphalt mixture
under different mixing processes were studied using the high-temperature rutting,
low-temperature bending, and immersion Marshall tests.

Results:
An increase in temperature is beneficial for SBS-T to reach a rapid melting
state. The fluorescence microscopic area reaches its maximum at a mixing temperature
of 180°C, a mixing time of 60s~75s without asphalt, and a mixing time of 120
seconds with asphalt.

Conclusion:
The mixing process of SBS-T modified asphalt mixture is as follows:
modifier content of 6%~7.5%, mixing temperature of 170°C~180°C, mixing time of
60s~75s without asphalt, and mixing time of 120s with asphalt.
Maximizing Emotion Recognition Accuracy with Ensemble Techniques on
EEG Signals
Authors: Jha Sonu Kumar , Suvvari Somaraju , Kumar Mukesh 
Published: January 2024

Background::
Emotion is a strong feeling such as love, anger, fear, etc. Emotion can
be recognized in two ways, i.e., External expression and Biomedical data-based. Nowadays,
various research is occurring on emotion classification with biomedical data.

Aim::
One of the most current studies in the medical sector, gaming-based applications, education
sector, and many other domains is EEG-based emotion identification. The existing research
on emotion recognition was published using models like KNN, RF Ensemble, SVM, CNN, and
LSTM on biomedical EEG data. In general, only a few works have been published on ensemble
or concatenation models for emotion recognition on EEG data and achieved better results than
individual ones or a few machine learning approaches. Various papers have observed that CNN
works better than other approaches for extracting features from the dataset, and LSTM works
better on the sequence data.

Method::
Our research is based on emotion recognition using EEG data, a mixed-model deep
learning methodology, and its comparison with a machine learning mixed-model methodology.
In this study, we introduced a mixed model using CNN and LSTM that classifies emotions in
valence and arousal on the DEAP dataset with 14 channels across 32 people.

Result and Discussion:
We then compared it to SVM, KNN, and RF Ensemble, and concatenated
these models with it. First preprocessed the raw data, then checked emotion classification
using SVM, KNN, RF Ensemble, CNN, and LSTM individually. After that with the mixed model
of CNN-LSTM, and SVM-KNN-RF Ensemble results are compared. Proposed model results
have better accuracy as 80.70% in valence than individual ones with CNN, LSTM, SVM, KNN,
RF Ensemble and concatenated models of SVM, KNN and RF Ensemble.

Conclusion::
Overall, this paper concludes a powerful technique for processing a range of EEG
data is the combination of CNNs and LSTMs. Ensemble approach results show better performance
in the case of valence at 80.70% and 78.24% for arousal compared to previous research.
Cosmetic Science Applied to Dentistry and Teeth: An Analytical Appraisal
Authors: Touyz Louis Z.G. 
Published: January 2024

Abstract:
The term cosmetics conventionally encompasses the application of beautifying
products and processes for skin and may also be applied to teeth. Although cosmetic dentistry
strives to produce immediate amelioration of appearance, it is not durable, can invoke undesirable
tissue reactions, may be gratuitously decorative, may not be ideally functional and
could have compromising results. There are differences between cosmetic and esthetic dentistry.
This appraisal re-affirms differences between them and provides examples to illustrate
differences.
Persepsi Wisatawan Terhadap Pengelolaan Destinasi Wisata Broken Beach Sebagai Daya Tarik Wisata
Authors: Syahputra Aldi Reza , Widiastiti A.A Istri Putera , Muliadiasa I Ketut 
Published: January 2024

Produk wisata merupakan salah satu hal yang sering dipertimbangkan wisatawan untuk mengunjungi suatu destinasi sehingga perkembangan produk wisata perlu dilakukan, hal ini agar dapat menarik minat wisatawan untuk berkunjung. Dalam proses pengembangan langkah-langkah strategi yang diambil perlu banyak pertimbangan dan berdasarkan kebutuhan wisatawan atau persepsi. Penelitian ini bertujuan untuk mengetahui persepsi wisatawan terhadap destinasi wisata Broken Beach, Nusa Penida. Pada penelitian ini, peneliti menggunakan metode penelitian deskriptif dengan menggunakan pendekatan kuantitatif. Sumber data yang digunakan berupa sumber data primer dan sekunder. Data primer didapatkan melalu hasil wawancara langsung dan pengisian berupa kuesioner yang disebarkan kepada 50 orang responden yang merupakan wisatawan yang sudah pernah berkunjung ke Broken Beach, Nusa Penida. Terdapat 2 teknik pengumpulan data yang digunakan dalam penelitian ini yaitu kuesioner yang disebarkan kepada 50 orang responden yang merupakan wisatawan dan teknik pengumpulan data terakhir berupa observasi. Analisis data pada penelitian ini menggunakan uji validitas dan reabilitas untuk mengetahui data yang didapat dari penelitian valid atau tidak. Selanjutnya hasil penelitian ini dapat menunjukkan bagaimana persepsi persepsi wisatawan terhadap destinasi wisata Broken Beach, Nusa Penida.

Tourism products are one of the things that are often considered by tourists to visit a destination so that tourism product development needs to be done, this is so that it can attract tourists to visit. In the process of developing the strategic steps taken, many considerations need to be made and are based on tourist needs or perceptions. This study aims to determine tourist perceptions of the tourist destination Broken Beach, Nusa Penida. In this study, researchers used descriptive research methods using a quantitative approach. The data sources used are primary and secondary data sources. Primary data was obtained through interviews in the form of questionnaires which were distributed to 50 respondents who were tourists who had visited Broken Beach, Nusa Penida. There are 2 data collection techniques used in this study, namely questionnaires distributed to 50 respondents who are tourists and the final data collection technique in the form of observation. Data analysis in this study used validity and reliability tests to determine whether the data obtained from the research was valid or not. Furthermore, the results of this study can show how tourists perceive the tourist destination of Broken Beach, Nusa Penida.
Menyoal Dekonstruksi Keadilan Sahabat: Kritik atas Muhammad Tahir Alibe
Authors: Shidqon Alfan , Rifqa Zakiyan 
Published: January 2024

This article provides a review of 'Adalah al-Shahabah Kepada Rekonstruksi Definisi Sahabat: Kajian Kritis Mengenai Sahabat dalam Tinjauan Nas by Muhammad Tahir Alibe. In the article, Tahir presents two main points: a redefinition of the term "companions" and a rejection of the "all companions are fair" rule in hadith sanad criticism. The review in this article focuses on three key issues: Firstly, the negative portrayal of the history of the Companions. Secondly, the analysis of arguments supporting and opposing the fairness of the Companions. Thirdly, a critical assessment of the redefined term "companions." To accomplish these objectives, this article employs a comparative literature-based research approach. The findings of this review reveal: Firstly, the historical narrative of the Companions in Tahir's article demonstrates bias. Secondly, the mapping of pro and con arguments lacks balance. Thirdly, the proposal to redefine the term "sahabat" requires further examination.

ABSTRAK
Artikel ini berisi ulasan atas Dekonstruksi ‘Adalah al-Shahabah Kepada Rekonstruksi Definisi Sahabat: Kajian Kritis Mengenai Sahabat dalam Tinjauan Nas oleh Muhammad Tahir Alibe. Dalam artikel tersebut, Tahir menawarkan dua hal: pendefinisian ulang istilah sahabat dan penolakan atas kaidah “semua sahabat adil” dalam kritik sanad hadis. Ulasan dalam artikel ini berfokus pada tiga persoalan: Pertama, narasi negatif sejarah sahabat. Kedua, pemetaan argumentasi pro dan kontra terhadap keadilan sahabat. Ketiga, tinjauan kritis atas pendefinisian ulang istilah sahabat. Guna mencapai maksud tersebut, artikel ini menggunakan riset pustaka berbasis komparasi. Hasil dari ulasan ini menunjukkan: Pertama, narasi sejarah sahabat dalam artikel Tahir mengandung bias. Kedua, pemetaan argumentasi pro dan kontra kurang berimbang. Ketiga, tawaran pendefinisian ulang istilah sahabat perlu ditinjau ulang.
Strategi Rasulullah dalam Menyatukan Kaum dengan Pendekatan Moderat dalam Islam
Authors: Hasibuan Miftahul Ihyaiddin 
Published: January 2024

Indonesia, with its diversity of ethnicities, traditions, religions, and languages, possesses abundant cultural potential but also serves as a source of potential conflicts. In this context, moderate Islam emerges as a solution to avoid extremism. This research explores the leadership legacy of Prophet Muhammad as an inspiration in formulating a strategy for religious moderation amid the complexity of Indonesian society. The research methodology employs a literature review to delve into the understanding of religious moderation in Islam. The study highlights that Prophet Muhammad, as an extraordinary leader, demonstrated leadership based on justice, honesty, exemplary behavior, and concern for his community. In handling conflicts, he exhibited patience, openness in dialogue, and used friendly language. Additionally, he comprehended the needs and concerns of the community, gradually taught Islam, and employed gentle communication. Therefore, a strategy for religious moderation can be crafted by referring to the leadership legacy of Prophet Muhammad, aiming at sustaining unity and harmony in Indonesia.
ABSTRAK
Indonesia, dengan keberagaman suku, adat, agama, dan bahasa, memiliki potensi budaya yang melimpah namun juga dapat menjadi sumber konflik. Dalam konteks ini, Islam moderat muncul sebagai solusi untuk menghindari ekstremisme. Penelitian ini mengeksplorasi jejak kepemimpinan Rasulullah sebagai inspirasi dalam menyusun strategi moderasi beragama di tengah kompleksitas masyarakat Indonesia. Metode penelitian studi kepustakaan digunakan untuk menggali pemahaman tentang moderasi beragama dalam Islam. Kajian ini menunjukkan bahwa Rasulullah sebagai pemimpin luar biasa, menunjukkan kepemimpinan berdasarkan keadilan, kejujuran, keteladanan, dan kepedulian terhadap umatnya. Dalam menangani konflik, Rasulullah menunjukkan kesabaran, keterbukaan dalam berdialog, dan menggunakan bahasa yang bersahabat. Beliau juga memahami kebutuhan dan keprihatinan umat, mengajarkan Islam secara bertahap, dan menggunakan komunikasi yang lemah lembut. Dengan demikian, strategi moderasi beragama dapat dibentuk dengan merujuk pada jejak kepemimpinan Rasulullah, mengarah pada keberlanjutan persatuan dan harmoni di Indonesia.
Takhrij Hadits: Pemahaman, Metode, dan Tujuan
Authors: Ismail Nurjannah , Hidayat Encang Sarip 
Published: January 2024

Hadith, as one of the sources of Islamic law, plays a crucial role in guiding the Muslim community. However, the level of certainty regarding hadith varies; some are mutawatir with a authority comparable to the Quran, while others are ahad, requiring further research into the characteristics of their narrators. This study aims to comprehensively describe the intricacies of takhrij hadith and illustrate the significance of this research in maintaining the integrity of hadith as one of the primary sources of Islamic law. Through this study, it can be identified that a profound understanding of the characteristics of hadith, the status of narrators, and the authenticity of hadith is crucial. The process of takhrij provides rich information about the chain of transmission (sanad) and the content (matn) of hadith. Takhrij of hadith is not merely a method; it is also a holistic approach that opens a window to a profound understanding of the scholarly heritage of Islam.
ABSTRAK
Hadis sebagai salah satu sumber hukum Islam, memiliki peran penting dalam membimbing umat Muslim. Namun, tingkat kepastian hadis berbeda-beda; ada yang mutawatir dengan otoritas serupa Al-Quran, dan ada yang ahad, memerlukan penelitian lebih lanjut terkait sifat-sifat perawinya. Kajian ini bretujuan untuk mendeskripsikan tentang seluk-beluk takhrij hadis dan pentingnya penelitian ini dalam menjaga integritas hadis sebagai salah satu sumber utama hukum Islam. Dari kajian ini dapat diketahui bahwa pemahaman mendalam mengenai sifat-sifat hadis, status perawi, dan autentisitas hadis merupakan hal yang sangat penting. Proses takhrij memberikan informasi yang kaya tentang keadaan sanad dan matan hadis. takhrij hadist bukan hanya sekedar metode, tetapi juga suatu pendekatan holistik yang membuka jendela menuju pemahaman yang mendalam terhadap warisan keilmuan Islam.