bluuebunny/crossref_metadata_2025_split huggingface dataset:
Philologische Überlegungen zu Röm 2,28–29 und zu Röm 2,17–20
Authors: Förster Hans 
Published: February 2024

Zusammenfassung
In der neueren Diskussion um Röm 2,28–29 wird eine unveröffentlichte philologische Studie zitiert, die zu weitreichenden Schlussfolgerungen Anlass gibt. Das dadurch aufgezeigte Desiderat einer detaillierten philologischen Untersuchung dieser Passage unter Anführung möglicher syntaktischer Vergleichsstrukturen wird durch die vorliegende Untersuchung erfüllt. In diesem Zusammenhang legt es sich nahe, die grammatikalische Möglichkeit aufzuzeigen, dass gegen die herrschende Meinung in Röm 2,17–20 kein Anakoluth vorliegt. Hierdurch eröffnen sich bisher wenig beachtete Perspektiven für das Verständnis dieser Passage im Kontext der paulinischen Verkündigung.
The relationship between childhood trauma and internet addiction in adolescents: A meta-analysis
Authors: Tang Haishan , Li Yuanyuan , Dong Wanglin , Guo Xiajun , Wu Sijia , Chen Chaoran , Lu Guangli 
Published: February 2024

AbstractObjectiveMany studies have explored the relationship between childhood trauma and internet addiction from different theoretical perspectives; however, the results have been inconsistent. The purpose of this meta-analysis was to examine the relationship between childhood trauma and internet addiction.MethodsThe PubMed, Web of Science, Embase, CNKI, Wanfang and VIP electronic databases were searched to identify studies examining the correlation between childhood trauma and adolescent internet addiction. The databases were searched from inception to December 31, 2022. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias of the included studies. Then, Stata 17.0 software was used to perform meta-analysis.ResultsThis study was registered on PROSPERO (CRD42023388699). A total of 19 studies involving 21,398 adolescents were included in this meta-analysis. The random effects model was used for pooled analysis, and the results revealed a strong positive association between childhood trauma and internet addiction (r = 0.395, 95% CI [0.345, 0.442]). The relationship between childhood trauma and internet addiction was moderated by sample size, survey area, and internet addiction measurement tools. There were significant differences between the associations based on the various child trauma measurement tools and study quality scores. However, interstudy heterogeneity was not significantly affected by study year, sample source, or participant age.ConclusionInternet addiction is positively correlated with childhood trauma. Therefore, it is extremely important for parents to provide a good growth environment during childhood to enhance the physical and mental development of adolescents. A warm family atmosphere helps individuals develop a healthy personality, thereby reducing or preventing the occurrence of internet addiction. Due to the limited number and low quality of the included studies, the above conclusions need to be verified by additional high-quality studies.
Metachronous Multifocal Osteosarcoma After 5-month Therapy: Metastasis or Other Primary Lesion?
Authors: Astien Astien , Hairunisa Nany , Abikusno Nugroho , Abikusno Revalita , Agil Nadifa , T Febrina 
Published: February 2024

Multifocal osteosarcoma is a rare form osteosarcoma. It is diagnosed by having two or more lesions without any visceral damage. Osteosarcoma is characterized by having concurrent numerous lesions; the synchronous type, and metachronous type are characterized by non-concurrent multiple lesions form. This case reports a boy 4 years old with a left femur osteosarcoma; histopathologically confirmed as chondroblastic osteosarcoma. After 5 months of chemotherapy, a new lesion was found at the left side of the cruris and pedis bones that were multiple, destructive, permeative, and exhibiting periosteal reaction. No visceral damage was found. In this case, the patient had a primary lesion and new non-concurrently lesions and no visceral damage, as conclusion was diagnosed as metachronous multifocal osteosarcoma that had never been reported in Indonesia.
Correlation study of CBC derivatives and biochemical prognostic marker in covid-19 patients
Authors: Vijay Roshna 
Published: February 2024

: SARS-CoV2 infection induces inflammatory responses and acute lung injury in human beings. Infection causes certain haematological and biochemical changes in patients. This study aimed analyze the correlation between CBC derivatives and biochemical prognostic marker in COVID-19.: Total 80 individuals selected, 50 COVID-19 positive patients and 30 subjects negative for COVID-19 RT-PCR test. Blood collected was sent to NLR, RDW, assayed in Beckman Coulter DxH 800. Serum CRP estimated by Immuno-turbidimetric method, ferritin by CLIA. Plasma collected estimate for D-DIMER by CLIA. Unpaired T test & Pearson correlation (IBM SPSS 22.0) were used. : Elevated levels of NLR (p value &#60;0.001), RDW (p value &#60;0.001), FERRITIN (p value &#60;0.001), D-D-DIMER (p value &#60;0.001), CRP (p value &#60;0.001) some research parameters like LHD and RSF show significant decrease. In current study the NLR positively correlate to CRP (r value=0.5, p value &#60;0.001), NLR positively correlate to D-DIMER (r value=0.3, p value&#60;0.05), RDW positively correlated to CRP (r value=, 0.3, p value &#60;0.05), RDW negatively correlated to ferritin (r value=-0.439, p value &#60;0.001)LHD negatively correlated ferritin (r value=-0.316, p value=&#60;0.05), MAF negatively correlated to D-dimer (r value=-0.244 &#60;0.05), MSCV positively correlated with CRP (r value=0.336, p value= &#60;0.05).: The cytokine storm produced during covid-19 infection which inturn develop neutrophilia and lymphopenia, CRP production and also cause elevation of procoagulants &D-dimer. RDW and CRP are positively correlated they are elevated during inflammatory conditions.RDW and FERRITIN show negative correlation. Retrospective study have some limitation so future studies will reveal more information.
Assessment of serum markers in preeclampsia: A prospective study
Authors: Çiçek Hülya , Kuba Abdalrhman , Uğur Mete Gürol , Güllü Elif Bacak , Tepe Neslihan 
Published: February 2024

Preeclampsia is a disease characterized by hypertension, proteinuria, and edema that occurs after the 20th gestational week. It is among the most important reasons for maternal/perinatal morbidity and mortality. Although many studies have been carried out, the pathophysiology of the disease is not fully known. Many methods have been proposed for evaluating risk factors leading to preeclampsia. In the past, the methods used to predict preeclampsia have usually been focused on non-biochemical markers, but nowadays there is a shift towards biochemical markers. Recently, many biochemical agents have been started to be used in the prediction of preeclampsia. In this study, the evaluation of some serum biomarkers in the follow-up preeclampsia was aimed. Serum nesfatin, ezrin, placental protein 13, hypoxia-inducible factor 1-α subunit (HIF1A), and neuropilin 1 levels were examined with the ELISA method. In the study, 90 samples taken from subjects, including pre-treatment preeclampsia (n =35), post-treatment preeclampsia (n = 35), and healthy control (n = 20) groups were evaluated. The data obtained from the study was analyzed with SPSS 22.0. As a result of the statistical analysis, pre-treatment nesfatin-1, and ezrin levels were found significantly lower than post-treatment and the healthy control group and HIF-1A levels were found significantly higher. As a result of these analyses, pre-treatment and post-treatment PP13 levels were found to be significantly higher than the healthy control group.Considering the results obtained from the study, we can say that nestin, ezrin, HIF1A, PP13, and NRP1 are important biomarkers for predicting preeclampsia.
Hypoglossal and Glossopharyngeal Nerve Palsy After Anterior Cervical Decompression and Fusion
Authors: Simon Chad Z. , Du Jerry Y. , Parel Philip , Adida Samuel , Miller Payton M. , Qureshi Sheeraz 
Published: February 2024

Case:
A 69-year-old man underwent a C3-4 anterior cervical discectomy and fusion and developed postoperative hypoglossal and glossopharyngeal palsies that resolved with symptomatic treatment.

Conclusion:
Cranial nerve palsy is a rare and possibly under-reported injury after higher-level cervical spine surgery. Conscientious positioning and awareness of these nerves during surgical exposure are crucial to minimizing cranial nerve palsies. Proper workup to identify these palsies and differentiate them from other complications is necessary to guide proper treatment.
WITHDRAWN: HHO-UNet-IAA: Harris Hawks Optimization based Novel UNet-Inception Attention Architecture for Glaucoma Segmentation
Authors: khan yusera , Banerjee Tathagat , Narula Gagandeep Singh , Wason Ritika 
Published: February 2024

Abstract

An accurate diagnosis is significant in preventing blindness because ophthalmology is one of the most prevalent causes of blindness worldwide. Glaucoma is diagnosed with a scanning-laser-tomography examination of the optic nerve head. The surface topography of the optic nerve head is captured and analyzed by this technique. The manual delineation of the optic nerve head by a skilled ophthalmologist is required for the analysis that results in a diagnosis of the illness. Transfer learning based computerized glaucoma classification has achieved effective outcomes. This study presents and validates a novel heuristic-based UNet-Inception attention framework for glaucoma optic nerve segmentation and classification. The suggested technique is based on the concept of merging the benefits of two distinct networks, such as the UNet and Inception framework for automatic segmentation of Glaucoma, along with the blend of the Harris Hawks approach for selecting impact features and a hybrid loss function. Using a database of fundus images, the proposed design was evaluated and compared to several state-of-the-art methods. The integration of the UNet-Inception architecture with the Haris Hawk Optimisation technique in the field of ophthalmology image segmentation has shown potential for substantial enhancements in terms of accuracy, efficiency, and adaptability based on the performance evaluation of this study. Using their combined abilities, these components proposed an efficient, automated ophthalmic classification framework. The fitness evaluation based on Intersection over Union (IoU) indicates that the model's performance is in accordance with the segmentation task. With a median DSC of 0.9892 for the optical nerve head (ONH) segments and 0.98718 for delineating the optic nerve head layer (RNFL), the findings show that the suggested technique performs better than the other techniques in terms of segmented images.
Generation of robotized assembly order using Liaison and Matrix methods: A comparative study
Authors: Dash Parameswar , Sahu Basant Kumar , Dash Manaswini 
Published: February 2024

Abstract

A robotic assembly process must be properly developed to achieve the highest throughput, viability, and efficiency. A great variety of ways to order creation have been documented in various literatures, each with its own methodology. However, the majority of literature employs soft computing strategies to generate assembly orders. This paper compares two order generating approaches, the liaison method and the matrix method. The matrix method offers a wide variety of possible applications. This technique may be implemented into the robot motion control software and is also simpler to add into automation operations. This technique has a high degree of convergence and uniqueness. However, the building of matrices must be done properly in order to obtain the correct result. The liaison method employs a logical approach via a series of inquiries that result in the desired precedence connection among the components. Assembly orders are generated using precedence relationships. The success of this strategy is dependent on the responses to a set of questions sent to each liaison. This method's appropriateness is related to items that have fewer components. The two approaches that have been chosen are deliberated about and applied to arbitrarily chosen items, which serve as the basis for the creation of a fundamental and correct approach for the production of robotic assembly orders. The study demonstrates that robotic assembly cells may use the matrix technique. The goal of the ongoing effort is to increase the robotic assembly system's capacity and adaptability.
A New Nadarajah-Haghighi Distribution with Applications
Authors: Kumar Vijay , Chakraborty Abhishek , Arshad Mohd , Tiwari Anshika 
Published: February 2024

Abstract
We propose a new Nadarajah-Haghighi (NH) distribution by applying the record transmutation function to the NH distribution for enhanced flexibility in data modeling. We discuss the shape of the probability density function and hazard function. Furthermore, we obtain quantile function, moments and moment generating function of the distribution. Moreover, we study various estimators for the parameters, such as maximum likelihood estimators, ordinary least squares and weighted least squares estimators, Anderson-Darling estimators, and Cram´er-von Mises estimators. The biases and mean squared errors of these estimators are thoroughly examined through Monte Carlo simulation studies. To demonstrate the practical application of the proposed distribution, two real data analysis are considered. The results highlight the effectiveness of the proposed distribution in modeling real-life data, with the model exhibiting superior fitting performance compared to other competing models.
Efficient dye removal by Streptomyces cyaneus lacasse heterologously expressed within S. cerevisiae cell walls immobilized within tyramine-modified alginate beads using visible light photopolymerization
Authors: Stanić Dragana Josić , Kokar Nikolina Popović , Stošić Anja , Popović Milica Crnoglavac , Prodanović Olivera , Vladisavljević Goran , Prodanović Radivoje 
Published: February 2024

Abstract

Environmental pollution by synthetic dyes presents serious global problem, since they are not biodegradable in conventional anaerobic wastewater treatment. Many studies using enzymatic degradation of synthetic dyes, especially laccases were reported. For the lacasse immobilization, hydrogels obtained through UV photopolymerization have been commonly used. However, cross-linking with visible light presents a less harmful and invasive method with possible applications in tissue engineering. In this study, laccase from Streptomyces cyaneus was expressed on the surface of yeast cell walls, followed by cell lysis and immobilization within modified alginate beads. The resulting laccase biocatalysts were additionally crosslinked using visible light in the presence of riboflavin as a photoinitiator. Photopolymerization was confirmed by FTIR spectroscopy. The obtained biocatalysts with improved pH and temperature stability were obtained. At 60 ℃, cell wall-immobilized laccase entrapped in photopolymerized tyramine-alginate hydrogel showed 30% higher enzymatic activity compared to the non-photopolymerized tyramine-alginate biocatalyst, and 250% higher activity compared to the biocatalyst immobilized in native alginate beads. Photopolymerized biocatalysts were tested for the decolorization of different classes of synthetic dyes. The relative decolorization of Evans Blue and Remazol Brilliant Blue by photopolymerized biocatalysts reached 75% and 77%, respectively, without the addition of redox mediators.
Evaluation of short versus long course chemotherapy in the neoadjuvant setting in ovarian cancer
Authors: Alghandour Reham , Refky Basel , Elsalman Hasan , Saker Doaa , Zohdy Mohamed , Elbaz Sara , Hany Islam 
Published: February 2024

Abstract

Background:
There is a debate about the optimum number of neoadjuvant chemotherapy (NACT) cycles for ovarian cancer and its impact on survival.
Objective:
This study aimed to assess the optimum number (NACT) cycles that influence the surgical and pathological outcome and its impact on survival.
Methods:
retrospective cohort study, all patients included were newly diagnosed ovarian cancer who received NACT then underwent interval debulking surgery (IDA), presented to tertiary cancer center from July 2011 to December 2021.patients were classified into two groups according to number of NACT cycles. Group 1; Patients who received ≤ 4 cycles Group 2; Patients who received ≤ 5 cycles.
Results:
207 patients were included (130 patients in group 1, 70 patients in group 2). 63.1% of group I were stage III while 51.9% of group II were stage IV. There was no difference between two groups in pathological response to NACT (P = 0.9), or those who underwent optimal cytoreduction (P = 0.8). group 2 received a higher total dose of perioperative chemotherapy (median 8 VS 6 cycles) (P-value < .001). There were no significant differences between both groups regards overall (OS) or relapse free survivals (RFS) (P = 0.5. 0.1 respectively).
Conclusion
Receiving more than 4 cycles of neoadjuvant chemotherapy followed by cytoreductive surgery had no impact on achievement of optimal cytoreduction surgery or surgical morbidity and mortality and did not affect relapse free or overall survivals.
Bioaccumulation of cadmium in muscle and liver tissues of juvenile Yellowfin tuna (Thunnus albacares) from the Indian Ocean.
Authors: Jayaweera Dhanushka Dilini , Gunawickrama K.B. Suneetha , Evenset Anita , Kuganathan Sivashanthini 
Published: February 2024

Abstract

The present study evaluated the cadmium (Cd) levels and temporal variation of Cd in dark muscle, white muscle, and liver of juvenile Thunnus albacares. 72 individuals (Standard length: 50 -67cm; weight: 0.8 kg - 2.5 kg) were collected from the selected landing sites in Sri Lanka during the period between April 2021 to May 2022. Total Cd levels were analyzed using an inductivity-coupled Coupled Plasma Mass Spectrophotometer. The mean Cd levels (mean ± SD mg/kg dry weight) in different tissues varied with significantly higher levels in the liver (13.62 ± 0.98, p < 0.05), compared to dark muscle (0.52 ± 0.05), and white muscle (0.42 ± 0.04). Cd levels in liver tissues were positively correlated (p < 0.05) with the fish weight. The highest Cd levels in liver tissue and dark muscle were reported in October 2021 (26.35 ± 3.46, 0.93 ± 0.10 mg/kg d.w. respectively) while in white muscle, the highest Cd level was found in November (0.60 ± 0.07 mg/kg d.w.). The Cd levels reported in dark muscles, white muscles, and liver tissues were significantly higher (p < 0.05) during 2nd inter-monsoon than in the other monsoonal regimes. The measured Cd levels (mg/kg wet weight) in white and dark muscles, were well below the maximum permissible level (0.2 mg/kg wet weight) set by WHO/FAO, but in the liver tissues of all samples were above the level. Accordingly, the edible flesh (white and dark muscles) of T. albacares from the Indian Ocean can be considered safe for human consumption whereas the liver tissues are unsafe. A human with a body weight of 60 kg can consume white muscles up to 4.667 kg per week without exceeding the Provisional Tolerable Weekly Intake defined by WHO/FAO.
Understanding tumour growth variability in patient-derived breast cancer xenograft models identifies early responders and biomarkers of resistance to PARP inhibition
Authors: O'Connor Mark , Voulgarelis Dimitrios , Forment Josep , Herencia-Ropero Andrea , Polychronopoulos Dimitris , Bender Andreas , Serra Violeta , Yates James , Bulusu Krishna 
Published: February 2024

Abstract

Understanding mechanisms of resistance to PARP inhibitors (PARPi) represents a clinically relevant goal that is addressed in this study using a novel methodology. A framework has been developed formulating a mathematical model accounting for intrinsic resistance to the PARPi olaparib, identified by fitting the model to tumour growth metrics from breast cancer patient-derived xenograft (PDX) data. Pre-treatment transcriptomic profiles were used together with the calculated resistance in order to extract baseline biomarkers of resistance to olaparib, as well as potential combination targets. Predicted biomarkers were then assessed for validity and novelty through differential survival analysis, modelling of combination data and pathway enrichment analysis. The model provided both a classification of responses, as well as a continuous description of resistance, allowing for more robust biomarker associations and capturing the variability observed. 36 resistance gene markers were identified, including multiple Homologous Recombination Repair (HRR) pathway genes that are a key part of olaparib’s mechanism-of-action. High levels of WEE1 expression were also linked to resistance, highlighting an opportunity for combining a PARPi with the WEE1 inhibitor. This framework facilitates a fully automated way of capturing response to treatment, including intrinsic resistance, and accounts for the biological and pharmacological response variability captured within PDX studies and hence provides a precision medicine approach.
Comparison of the clinical performance of self-adhering flowable composite and resin-based pit and fissure sealant: a randomized clinical trial
Authors: gisour Elham Farokh , Jahanimoghadam Fatemeh , Aftabi Reyhaneh 
Published: February 2024

Abstract

Background: Self-adhering flowable composites are an innovative step in reducing the chair time of pit and fissure sealant treatment. This study aimed to compare the clinical performance of self-adhering flowable composite (SELF-ADH) and resin-based pit and fissure sealant (RBs).
Methods: This is a double-blinded, randomized, split-mouth clinical trial conducted on 80 fully erupted permanent mandibular first molars from 40 children aged 6 to 12 years. For each participant, two permanent molars were randomly treated with SELF-ADH or RB. All sealants were assessed at 3, 6, and 12-month follow-ups considering retention, marginal integrity, marginal discolouration, colour matching, surface texture, and caries recurrence. To analyse the data, logistic regression and Fisher's exact tests were used (significance level P < 0.05).
Results: At the 12-month follow-up, the number of fully retained sealants in the SELF-ADH group was 5.37 times greater than that in the RB group (P < 0.001). The success rate of marginal integrity in the SELF-ADH group was also 2.31 times greater than that in the RB group (P = 0.013), while the marginal discolouration was 2.23 times greater in the RB group (P < 0.001). The incidence of recurrent caries in teeth with partial loss of sealant in both groups (P = 0.004, P < 0.001) increased significantly over time.
Conclusion: The retention and marginal integrity of the self-adhering flowable composite were significantly greater than those of the resin-based sealant. Therefore, due to the small number of work steps, flowable self-adhering composites can be used as alternatives to resin-based pit and fissure sealants.
Trial registration: This study was approved by the Ethics Committee of Kerman University of Medical Sciences with the code IR.KMU.REC.1399.556 and Iraninan Registry of Clinical Trials (IRCT) code IRCT20180521039763N4, as well as full compliance with the Declaration of Helsinki