bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid Peroxidation, Lipid Profile, Serum Leptin and Glycemic Control in Patients With Ischemic Stroke:Role of Vitamin E Supplementation
Authors: Abdul-Jabbar Thanoon Imad , Dhiaa Kasim Sarraa 
Published: January 2024

Aims: To evaluate parameters of glycemic control (fasting serum glucose "FSG", serum insulin level and insulin resistance), serum leptin, malondialdehyde "MDA" and lipid profile (total cholesterol "TC", triglyceride "TG", low density lipoprotein cholesterol LDL-c, high density lipoprotein cholesterol HDL-c, very low density lipoprotein cholesterol VLDL-c and atherogenic index "AI" ) and body mass index (BMI) in patients with ischemic stroke and to test the influence of vitamin E supplementation on these parameters, Methods: This study included 62 ischemic stroke patients and 28 healthy control subjects. Patients were randomly divided into 2 groups: group I (n=33) involved patients with ischemic stroke who assigned to receive conventional therapy and group 2 (n=28) included patients who received conventional therapy with oral supplementation of vitamin E (400 IU/d) for 30 days. Fasting blood samples were initially obtained from all patients within 24-48 hours after the accident (before starting treatment) and from the controls and assay of FSG, serum insulin, leptin, MDA, TC, TG, HDL-c and calculation of insulin resistance, BMI, LDLc, VLDL-c and AI using especial equation were done. For the patients groups, another fasting blood samples were taken after therapy and assessment of the parameters mentioned above were done, Results: Before therapy, there was a significant differences between patients in group one ( on conventional therapy alone) and the controls with regard FSG, serum leptin, MDA, and AI, while there was a significant difference between patients in group 2 and the controls with regard FSG, serum leptin, MDA.After therapy, there was a significant increase in HDL-c with significant decrease in serum insulin, leptin , MDA and AI in patients in group one, with significant increase in BMI and significant reduction in serum leptin, MDA, TC, TG, VLDL-c, LDL-c and AI in patients in group 2 compared to pre-therapy stages.By comparison of the net differences of both groups after therapy, there was a significant reduction in the MDA and TC in patients in group 2 compared to patients in group one, Conclusion: Acute ischemic stroke might be associated with disturbances in some parameters of glycemic controls, lipid profile, elements of oxidative stress and serum leptin. Vitamin E supplementation during the early post ischemic period resulted in reduction in oxidative stress and improving some parameters of lipid profile.
Prevalence of Metallo-Î²-Lactamaseproducing Pseudomonas aeruginosaisolated from different clinical samples in Baghdad province
Authors: H. Al-Charrakh Alaa , Jaber Al-Awadi Salwa , Salim Mohammed Ahmed 
Published: January 2024

Background: Metallo beta lactamase(MBL) producing Pseudomonas aeruginosahave been reported to be an important nosocomialinfections.Pseudomonas aeruginosa is a leading cause of nosocomial infections, giving risetoa wide range of life-threatening conditions. Its intrinsic & acquired resistance to many antimicrobial agents and its ability to developmultidrug resistance imposes a serious therapeutic problem. Materials and Methods: A total of 75 P.aeruginosaisolates were isolated from different clinical samples in some public & private hospitals in Baghdad city during the period from April to August 2011.Bacterial identification was done using conventional cultural & chemical methods &and VITEk 2 cards for identification (GN), while the minimum inhibitory concentration (MIC) testing was performed using disk diffusion,E-test for Imipenem& Meropenem(oxoid, UK) & (AST-GN30)cards in VITEK 2 automated system(bioMÃ©rieux, , France). Each P.aeruginosa isolates showed resistance to Carbapenems(Imipenem& Meropenem) were subjected to Imipenem-EDTA combined disc synergy test (CDST) to investigate the production of MBL(confirmative test) Results:Out of 75 P.aeruginosa isolates,16 (21.3%) were grow on MacConkey agar supplemented with Meropenem4mg/L (MMAC),this method used as screening test, The MIC of different antibiotics was performed on these isolates using different methods(VITEK2AST-GN30,Imipenem&Meropenem E-test) showed that 6 (37.5%) isolates were Carbapenem resistant MIC â‰¥16Î¼g/ml,while 4(25%) pseudomonas isolates appear to be MBL producer usingImipenem-EDTA combined disc synergy test(CDST).
Discussion: MBL mediated carbapenemresistance in P. aeruginosa is a cause for concern in thetherapy of critically ill patients. The MBL producing P. aeruginosa isolates were more resistant to various antimicrobial agents. This result suggests that MBL producing isolates in hospitals may cause serious infections that illustrated when these strains were responsible for a nosocomial outbreak.The findings strongly suggest that there is a need to track the detection of MBL producers and that judicious use of carbapenems is necessary to prevent the further spread of these organisms. Conclusion: The prevalence of multi-drug resistant P.aeruginosa isolates especially Carbapenem resistant bacteria was increased in Baghdad province.Phenotypic characterization of MBLs provide information about the prevalence of MBLs producing P. aeruginosa in Baghdad.
Quality of life of outpatients with schizophrenia from Urban and Rural areas in Baghdad
Authors: Dawood Jassam Mohammed , Hussain Al-Aamry Ali , Ibrahim Hamdan Ali , Abod Al-mishhadani Gazi 
Published: January 2024

Background:Increasing interest in quality of life is the new approach for understanding and improvement of healthcare. Although there are many studies about quality of life in schizophrenic disorder, there is deficiency of data about quality of life of schizophrenic patients in urban and rural areas.Objectives:1-To study the quality of life of schizophrenic patients who are living in both rural and urban areas.2-To identify any possible factors that might need further attention for treatment planning programs.
Methods:This study was prospectively conducted between October 2010 and May 2011, on 126 schizophrenic patients attending the outpatient clinic in Al-Rashaad training Hospital.we explain the purpose of the study to patients and take their consent; patients should have stable clinical condition (on regular treatment for at least 6 months, continuous course, not agitated or confused). International Diagnostic check list of (ICD 10)(9) andWorld Health Organization(WHO)Quality of life (QoL)-100 Arabic version(10) were used.Results:Patients from rural areas scored significantly higher than urban patients in all six domains (Physical health, Psychological health, Level of independence, Social relationships Environmental, and Spiritual domain) . Studying different demographic variables in correlation with quality of life ,showed the same manner .Conclusion:This study showed that schizophrenic patients living in rural areas, had relatively better quality of life than those living in urban areas.
Environmental Pollution and Risk of Congenital Anomalies in Al-Diwaniya Governorate
Authors: Jabor  Suhail Hadi 
Published: January 2024

Analytic study, conducted on 15 cases of congenital deformity of the newborn babies in the maternity and children's teaching hospital in Diwaniya for the period from the first of January until the end of December 2014 (6 males and 9 females) , were recorded cases include cardiac defects , urinary system anomalies , neural tube defects , cleft lip 'and Down syndrom.
The largest percentage is cardiac malformations and abnormalities of the urinary system,
the proportion of malformations among females were more than in males , for the place of residence was a al- Jumhoory locality in the top of the other 'as to the nature of the environment there were no any strange environmental phenomenon or different from other regions environment' except al- Jumhoory locality had seen very violent military conflicts.
Estimation of tear film break up time in normal peoples of Diwaniya,Iraq
Authors: Aswad. Al-Hemidawi Haider 
Published: January 2024

Objective: to estimate tear film break- up time , a test of tear film stability in normal Iraqi population.
Material and method: 286 normal subjects ( 146 male and 140 female ) age from 12 to 78 years were participated in this study, tear break -up time is estimated using impregnated fluorescein strip wetted with normal saline and the measurement is done in one room with stable temperature and door closed , three readings for each subject and the mean is taken .
Results: The
Objective: to estimate tear film break- up time , a test of tear film stability in normal Iraqi population.
Material and method: 286 normal subjects ( 146 male and 140 female ) age from 12 to 78 years were participated in this study, tear break -up time is estimated using impregnated fluorescein strip wetted with normal saline and the measurement is done in one room with stable temperature and door closed , three readings for each subject and the mean is taken .
Results: The mean TBUT in this study was 15.3 second with SD 4.7 ( range from 6-28s), the study show TBUT to be decreased with age, The study show significant difference in result between male and female.
Conclusion : The tear break -up time (TBUT)values in this study are comparable to those reported for Asian population but much less than those for western population; there is significant difference between gender and the results tend to decrease with age.
Immunoflourecent Staining Detect the Prognostic significance of M2 macrophage
Authors: AbdulAlla Hussain Aseel , Abdulmajeed     Altamemi Ibrahim , Wali Ali Thair 
Published: January 2024

Tumor cells use multiple mechanisms to invade extracellular matrix and metastasize to distant organs. The interaction between the tumor cells and stromal cells in the tumor microenvironment plays an important role in tumor growth and metastasis. Tumor associated macrophage (TAM) are prominent stromal cells in this interaction. They secret a variety of growth factors, cytokines, chemokines, and enzymes that regulate tumor growth, angiogenesis, invasion, and metastasis. Macrophages show two polarization states in response to different micro-environmental signals. M1macrophages are pro-inflammatory and function as bactericidal and antigen-presenting cells. M2 macrophages have an immunosuppressive phenotype.
Thus the aim of current study is to find out whether there is prognostic value for M2 macrophage that infiltrating colorectal tumor tissue through linking its expression level with tumor histopathological variables by using immunoflourecent technique. Further more to find if there an association for M2 macrophage with tumor cell proliferation by using Ki67 as a proliferation marker.
Current study found that the Mean Ki67 score was significantly higher in patients than in control group, (P<0.001), moreover the common macrophage mean CD68+ macrophages, and M2 macrophage (CD163+) count was significantly higher in patients than in control group (P<0.001, P<0.001), respectively. I addition present study demonstrated that the M2 macrophage (CD163+) count showed significant correlation with tumor grade (P<0.001), LN involvement (P<0.001), stage (P<0.001), and Ki67% (P<0.001). However, when the ratio of CD68/CD163was considered, the following results were obtained: there was no significant correlation between CD68/CD163 ratio and both of tumor stage and LN involvement (P>0.219, P>0.468 respectively). While there was significant correlation between CD68/CD163 ratio and tumor grade (p<0.03).
From above results one can conclude that high expression of CD163 macrophages is associated with poor prognosis and from other hand could be targeted by immune therapy to lower the progression of colorectal cancer.
Overexpression of p53 gene has an important role in induction and progression of breast carcinoma
Authors: A. Al-hamadawi Hussein , A. Al-Janabi Assad , W. Al-bider1 Adnan 
Published: January 2024

Breast cancer is the most common cancer in women, accounting for 23% of all female cancers around the globe. breast cancer molecular disease occurs due to the alteration in the genes that control cell growth and proliferation , such as HRE2/neu, c-MYC, K-RAS, RB, P53,PTEN,BRCA1 and BRCA2. The p53 tumor suppressor gene is located on chromosome 17p13, consists of 11 exons and encodes a53-kDa nuclear phosphoprotein, that has a very important function in many cellular processes, such as cell-cycle control, DNA repair , apoptosis and gene transcription. p53 is the most common mutated gene in human cancers , including breast. The aim of this study was to study the correlation between the overexpression of p53 and clinicopathological parameters in breast cancer patient. The current study included 85 sample of Paraffin-embedded breast cancer tissues, which were analyzed for p53 overexpression by immunohistochemistry. We also studies correlation between p53 overexpression and clinicopathological parameters.
The results have clarified that 64.7% (55 out of 85) of cases of breast cancer had high expression of P53 immunostaining in their histological sections ,while 35.3% of cases were negative for p53 expression. The p53 expression was significantly correlated high grade and stage as well as age group less than 50 years ,and there was no significant correlation between p53 expression and gender of patient, lymph node status, tumor size, tumor site and histological types.
Conclusion: These results demonstrated the overexpression of p53 in more than half of breast cancer cases and that overexpression of p53 was well correlated with grade and stage as well as young age group less than 50 years breast cancer patients.
Intussusceptions Analysis of 57 cases of intussusceptions at Alkarama Teaching Hospital Wassit-Al-kut
Authors: Ibraheem Khaleel Haider , Ali Abed Ahmad Hussein 
Published: January 2024

This is a prospective study of 57 cases of intussusception who were admitted to the Alkarama Teaching Hospital inAl-kut from the 1st of October 2011 to the 1st of March 2014.
Age ranging was from one month to three years and the mean age was (6 months); the commonest age group affected was those between (6-12) months , the male: female ratio was (1.7:1) , the disease was more prevalent in spring time .
The cardinal symptoms were abdominal pain in 55 patients (96.5%), followed by the passage of red currant jelly stool in 50 patients (87.7%) and vomiting was present in 45 patients (78.9%).
The most common sign was abdominal mass in 31 patients (54.4%) .
Most of the patients 35 (61.4%) presented in the (24-48) hours from onset of symptoms.
In diagnosis we depended mostly on the clinical picture of the disease supported by plain abdominal x-ray , ultrasonography as Barium enema was not feasible.
Surgical management was the only option for alatients. Simple manual reduction of the bowel with appendectomy was the procedure in 44 (77.2%) of patients and in 7 patients (12.3%) resection was done due to gangrenous bowel with primary anastamosis which was not possible in one of them (1.8%) and ended with ileostomy
Six patients (10.5%) had secondary intussusception and in 4 of them , Meckel`s diverticulum was the lead point and the other 2 cases the polyps were the cause and all were treated by resection and primary anastamosis. Postoperative complications were recorded in 21 patients (36.8%) and mortality rate was recorded in one patient (1.8%).
Use of isotretnion to decrease recurrence of chalazion
Authors: Adil Hashim Al-Hassnawi Zainab 
Published: January 2024

Chalazion; is a nodular swelling occur as a result of accumulation of sebaceous secretions from abnormally functioned sebaceous glands situated in the eye lid causing ocular surface problems like dryness , irritation and refractive error due to pressure effect on the cornea in addition to cosmetic blemish ,topical treatment usually ineffective so we do surgical drainage . isotretnion is one derivatives of retinol a chemical name of the essential micronutrients vitamin A which have important role in human reproduction and development in addition this drug is well known by dermatologist and it is commonly used for treatment of seborrhea and other skin problems related to sebaceous glands. This present cross sectional study was done at AL-Diwaniah teaching hospital(ophthalmology department) at AL-Diwaniah city from September 2014- January 2017 ,110 patients (63 female,47 male) ,between 17-35years old are involved in this study attend ophthalmological department complaining from recurrent (or multiple) chalazion ,those patients had been given isotretnion orally a dose of 20 mg/day for10 - 12 weeks and followed for 6-12 months for re appearance of chalazion the result show decrease in the recurrence rate of chalazion with improvement in the tear film quality and ocular lubrication.
Histopathological study on maternal pancreas, placenta and fetal pancreas at 18th day postgestation of streptozotocin induced maternal diabetic rats (Rattus norvegicus), and the effect of n-butanolic extract of celery seeds (Apium graveolens)
Authors: Khalil AlMalaak Maha , Abd Ali Almansour Nasir , Miran Hussein Zahida 
Published: January 2024

The study is designed to clarify the influence of induced maternal diabetes mellitus on placenta and the fetus at 18th day of gestation. Diabetes mellitus was induced in (24) female's rats (Rattus norvegicus) before mating by streptozotocin (60 mg/kg of animal body weight) one dose intrapersonal injection, all animals were isolated and divided into two groups (non-diabetic and diabetic group), each group was composed of (12) female, also each group was subdivided into two groups, healthy females group as control and the subgroup treated with n-butanolic extract of celery seeds (60 mg/kg of body weight daily). The diabetic group also had been subdivided into two groups, another one of them had been treated with celery seeds extraction, and one had diabetes mellitus without treatment. There were many macroscopic observations reported by the current study, include the still birth in addition to differences in size between the fetuses which was tend to increased (macrosomia) in the diabetic groups resulted from hyperglycemic mother. Microscopic study detected harmful effects of diabetes mellitus on the tissues, while in the other hand there are a regeneration in islets of Langerhans when treated the animals with n-butanolic extraction of celery seeds with slightly heal in certain points in tissues, also had seen some of the side effects of treated with extract.
Prevalence of under nutrition and associated maternal risk factors in children under five years of age in Babylon 2013
Authors: Abdul Abbas Ahmed , Kuhtan Mohammed Sura 
Published: January 2024

Background:Malnutrition is one of most serious world health problems and is the major cause of illness and death throughout the world. It is associated with about half of all child death. It affects physical growth, morbidity, mortality, cognitive development, reproduction, and physical work capacity, and it consequently impact on human performance, health and survival. Thus, when attempting to reduce child mortality, monitoring and reducing the prevalence of malnutrition in vulnerable population is essential. Malnutrition is an outcome of various factors resulting from unfavorable socioeconomic circumstances.
Objective: To determine the prevalence of undernutrition (wasting, stunting and underweight) and associated maternal risk factors of children under 5years in Babylon.
Methods: Across-sectional study design was used to study a group of 400 children, aged 2- 60 months. The sample was convenient, the data collected from four health centers during the period from 25th of February to 10th of May 2013. Assessment of maternal risk factors for child malnutrition was accomplished through a structured questionnaire used to interview child’s mother. The anthropometric measurements were assessed according to standard techniques used to calculate z-score for height for age (stunting), weight for height (wasting) and weight for age (underweight). As reference curve, the World Health Organization Child Growth Standard was used
Results: The prevalence of malnutrition of children under five years in Babylon was 19.25% found as 15% for stunting, 3%for wasting and 4.75% for underweight. The majority 52% were males, 48% were females. Malnutrition was higher among children aged 13-24months (35%) and higher among family who had three or more children less than 5 years (16%). Also the study revealed that malnutrition was higher among mothers who had primary education (62%). Higher prevalence (66%) was present among children who live in rural area. In this study, the prevalence of acute malnutrition (wasting) was higher among infant aged 2-12 months (84%) and higher prevalence of wasting (50%) among those children who had history of illness (acute or chronic).
Conclusion: There was high prevalence of malnutrition in Babylon and there are several risk factors associated with malnutrition. Prominent risk factors include low educated mothers, child age, child birth order, high numbers of children under five years and living in rural area.
Zinc status among children with bronchial asthma in central child's teaching hospital/Baghdad
Authors: Mohammed Murad Mahdi , Salim Ismail Mohannad , M Al-Dulaimy Khamees 
Published: January 2024

Background:Pediatric asthma is a syndrome of lung dysfunction with an imbalance between the forces that maintain airway patency and those forces that operate to narrow or close the pediatric airway. Zinc has been supposed to have anti-oxidant, anti- apoptotic, anti-inflammatory and anti-allergic effects in the organism . Zinc deficiency is suspected to play a role in the pathogenesis, control, and severity of allergic, skin and airway diseases.
Objectives: To evaluate the relationship between zinc serum level and bronchial asthma( its duration and severity).
Patients and methods: A prospective case –control study was conducted at the central Child teaching hospital in Baghdad in a period extended for six months from 15th March to 15th September , 2016. 47 children from ages 2 to 12 years (mean age 5.6year ) of both gender who were known cases of asthma were enrolled in the study, matched in age and gender with the control group of 47 healthy children without history of chronic disease. The zinc concentrations in serum were measured in both cases and controls.
Results:A total of 94 children were included, 47 patients who were asthmatic (22 males& 25 females). Mean age of children with asthma and control group children was 5.6 year . Body mass index percentile was higher in asthmatic patients (p 0.001). The study shows that asthmatic children significantly more likely to have family history of asthma compared to control group (p<0.001). in this study the meanconcentrations of zinc are lower in asthmatic children(67.4µg/dl) incomparison tocontrols(86.1µg/dl). And a significant correlation between serum zinc level with each of asthma severity and use of steroids and bronchodilator , (p < 0.001) for each.There was no significant association between age , gender, Body mass index(BMI) family history and duration of asthma with the low serum zinc level . (p 0.923, 0.478, 0.343 and 0.138 respectively).
Conclusion:Serum zinc level is lower in patients with bronchial asthma regardless their age and gender, and serum zinc level has significant relation to the severity of asthma and the use of steroid.