bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heme iron as potential iron fortifier for food application – characterization by material techniques
Authors: Jarzębski Maciej , Wieruszewski Marek , Kościński Mikołaj , Rogoziński Tomasz , Kobus-Cisowska Joanna , Szablewski Tomasz , Perła-Kaján Joanna , Waszkowiak Katarzyna , Jakubowicz Jarosław 
Published: November 2023

Abstract
The modern food industry requires new analytical methods for high-demand food supplements, personalized diets, or bioactive foods development. One of the main goals of the food industry is to discover new ways of food fortification. This applies to food products or supplements for human and animal diets. In our research, we focused on the solid particles of AproTHEM (dried porcine hemoglobin), which is approved for animal feeding and as a meat product additive, and AproFER 1000 (heme iron polypeptides), which is still being investigated. The study showed the possible application of advanced techniques for the examination of iron-based food additives. We evaluated selected techniques for particle size and morphology examination such as laser diffraction, optical microscopy, as well as scanning electron microscopy, and briefly discussed their usefulness compared with other techniques. On the basis of our results, we proposed a path of microscopic analysis for the study of material homogeneity. The structure of heme iron was evaluated by X-ray diffraction, FT-IR, and Raman spectroscopy supported with thermal behavior analysis (differential scanning calorimeter). Furthermore, a portable colorimeter was applied for L*a*b* color analysis. Our study proved that for new food product development, particle size analysis as well as typically used advanced materials techniques can be successfully applied.
A monument’s many faces: the meanings of the face in monuments and memorials
Authors: Bellentani Federico 
Published: November 2023

Abstract
This paper presents a comprehensive analysis of the significance and meanings of faces within monuments and memorials. The presence of faces in monuments and memorials transcends cultures and spans throughout history. Faces serve as vital components of public statues, conveying the emotions of depicted characters and establishing communicative connections with observers. Moreover, they are employed within memorials to commemorate the deceased. Memorial museums frequently feature corridors adorned with portraits of those who perished in wars, terrorist attacks or natural disasters. The aim of this paper is twofold: firstly, to develop a theoretical and methodological framework for the analysis of faces in monuments and memorials, drawing upon the cultural semiotics of Juri Lotman as well as theories proposed by Algirdas J. Greimas and Umberto Eco. Secondly, to construct a typology that elucidates the various ways faces are utilized within monuments, memorials, and commemorative practices. A historical roadmap of the facial presence in monuments and memorials is then presented. By achieving these aims, this paper contributes to a deeper understanding of the meanings of faces within monuments and memorials in particular and memory politics in general.
Protein phosphatase 1 regulates core PCP signaling
Authors: Song Song , Cho Bomsoo , Weiner Alexis T , Nissen Silas Boye , Ojeda Naharros Irene , Sanchez Bosch Pablo , Suyama Kaye , Hu Yanhui , He Li , Svinkina Tanya , Udeshi Namrata D , Carr Steven A , Perrimon Norbert , Axelrod Jeffrey D 
Published: November 2023

AbstractPlanar cell polarity (PCP) signaling polarizes epithelial cells within the plane of an epithelium. Core PCP signaling components adopt asymmetric subcellular localizations within cells to both polarize and coordinate polarity between cells. Achieving subcellular asymmetry requires additional effectors, including some mediating post‐translational modifications of core components. Identification of such proteins is challenging due to pleiotropy. We used mass spectrometry‐based proximity labeling proteomics to identify such regulators in the Drosophila wing. We identified the catalytic subunit of protein phosphatase1, Pp1‐87B, and show that it regulates core protein polarization. Pp1‐87B interacts with the core protein Van Gogh and at least one serine/threonine kinase, Dco/CKIε, that is known to regulate PCP. Pp1‐87B modulates Van Gogh subcellular localization and directs its dephosphorylation in vivo. PNUTS, a Pp1 regulatory subunit, also modulates PCP. While the direct substrate(s) of Pp1‐87B in control of PCP is not known, our data support the model that cycling between phosphorylated and unphosphorylated forms of one or more core PCP components may regulate acquisition of asymmetry. Finally, our screen serves as a resource for identifying additional regulators of PCP signaling.
“TODO DIA ELA FAZ TUDO SEMPRE IGUAL”: PERCURSOS E NARRATIVAS SOBRE TRABALHO DE MULHERES QUE ATUAM COMO DIARISTAS NO DISTRITO FEDERAL
Authors: Lima Fernanda Santos 
Published: November 2023

A informalidade tem encontrado bases cada vez mais sólidas para a precarização, frente ao aprofundamento do cenário de crise e desemprego estrutural enfrentado pelo país. As diaristas se inserem neste campo enquanto trabalhadoras que exercem suas atividades sem vínculo formal, na medida em que a atividade se constitui enquanto metamorfose do emprego doméstico frente às alterações no mundo do trabalho. O objetivo desta pesquisa é investigar e refletir sobre os sentidos e representações produzidos por estas mulheres sobre seu cotidiano laboral e estabelecer uma breve discussão à luz da teoria feminista. Para isto, utilizamos de uma abordagem qualitativa onde realizamos entrevistas semiestruturadas com seis mulheres, onde evidencia-se a precariedade e subalternidade da atividade frente a um cenário de desgaste na medida em que as entrevistadas afirmam realizar mais de uma faxina por dia. Apesar disso, o fato de ser diarista aparece como elemento positivo ao criar condições para que sejam mais bem remuneradas do que empregadas com vínculo formal, o que revela também uma possível condição de precarização no vínculo celetista.
Stent-ception: implementation of soft double-J stents in the ureteric Memokath-051<sup>TM</sup> in bilateral ureteric stricture post radiotherapy for advanced prostate cancer
Authors: Mohd Isa M. F. , Mohamed Ashraf M. D. , Yusof M. R. , Faiz N. G. , Merican S.R. H.I. 
Published: November 2023

Narrowing of ureter can be due to malignant or benign causes. Temporary double-J (DJ) stents, various metallic stent designs, or definitive corrective surgery can be the options management for ureteric stricture. As an alternative from DJ stents, Memokath-051TM (MMK-051TM) can be inserted in strictured ureters post radiotherapy for advanced prostate cancer patients. We present a case of an advanced prostate cancer which bilateral DJ Stents placed within MMK-051TM. A 76-year-old man with underlying hormone sensitive advanced prostate cancer completed radiotherapy. Post radiotherapy he developed bilateral ureteric strictures and bilateral DJ stents inserted. He had to underwent multiple change of stents due to blockage. Patient had MMK-051TM inserted, however complicated with blockage due to encrustation. Improvisation method done by putting the bilateral DJ stents within the MMK-051TM. Patient had no more blockage of MMK-051TM after the placement of DJ stents within it. However, patient succumbed to death a year after the last procedure. Our case report highlighted encrustation of metallic ureteric stents and a novel approach to overcome this problem. Introduction of additional DJ stents not only reduced the incidence of MMK-051TM blockage but also improved the quality of life of the patient.
Metanephric adenoma of the kidney: clinical case and literature review
Authors: Grebenkin E. V. , Pshikhachev A. M. , Osmolovskiy B. E. , Epishkina A. A. , Kozhevnikova E. Yu. , Sorokin N. I. , Kamalov A. A. 
Published: November 2023

Metanephric adenoma is a rare benign kidney tumor with a favorable prognosis. These neoplasms are often interpreted as malignant at the preoperative stage, since they do not have specific characteristics showing during instrumental imaging methods, which leads to excessive surgical treatment in the context of nephrectomy volume. Therefore, histological verification is the gold standard for diagnosis. The morphological features of metanephric adenoma are in many ways similar to such kidney tumors as papillary renal cell carcinoma and nephroblastoma (Wilms’ tumor), so sometimes additional research methods are required, including immunohistochemical and molecular genetic ones. In this article, we report a rare clinical case of metanephric adenoma in a forty-seven-year-old woman. The results of clinical and instrumental exams, as well as morphological features of the tumor are presented. A review of the literature on the clinical, morphological, and molecular aspects of this tumor is also presented.
The practical significance of using Canephron N medication for radiation cystitis prevention in patients undergoing radiation/chemoradiation therapy
Authors: Korotkikh N. V. , Moshurov I. P. , Andreeva O. V. , Zagryadskaya D. O. , Andreev V. A. , Kulikova I. N. , Kamenev D. Yu. 
Published: November 2023

Background. With increasing life expectancy in cervical cancer patients, new medical and social problems associated with radiation therapy become apparent. The combination of radiation therapy and chemotherapy is an important therapeutic component in treatment of malignant neoplasms of the genital area in women, but the frequency and severity of side effects has been increasing. Radiation complications occur in 20–50 % of patients. In 5 % of patients, they can represent a severe and potentially life-threatening condition. Prevention of negative effects on the genitourinary system in cervical cancer patients receiving radiation therapy on the pelvis is a matter of importance.Aim. To evaluate the clinical efficacy of a phytotherapeutic preparation Canephron N containing centaury, lovage root, rosemary leaves in the prevention of radiation cystitis during chemoradiotherapy in patients with advanced cervical cancer.Materials and methods. The study included 60 patients with locally advanced cervical cancer receiving radical chemoradiotherapy. The patients were divided into 2 groups: treatment group consisting of patients receiving phytotherapeutic preparation Canephron N for prevention of radiation complications, and control group consisting of patients not receiving symptomatic treatment. The treatment results were evaluated using questionnaires, clinical, laboratory and instrumental studies. The obtained data were compared with the results of treatment of the control group which were not prescribed a medication for prevention of urological complications.Results and conclusion. The use of Canephron N in accompanying therapy had significantly decreased the risk and incidence of radiation cystitis.
Acute kidney injury and its predictors in surgery of malignant kidney tumors
Authors: Pozdnyakov K. V. , Rakul S. A. , Eloev R. A. , Lukinov K. A. 
Published: November 2023

Aim. To analyze our own results of the course of early postoperative period in patients who underwent surgical treatment of kidney tumors: partial nephrectomy (PN) and radical nephrectomy (RN) and to identify risk factors for the development of acute kidney injury (AKI).Materials and methods. The study included 399 patients, of which 276 patients (69.17 %) underwent PN, 123 (30.83 %) underwent RN. According to the clinical stage of the disease, patients in the PN and RN groups were distributed as follows: cT1a – 160 (91.95 %) and 14 (8.05 %), cT1b – 99 (61.11 %) and 63 (38.89 %) and cT2a – 17 (26.98 %) and 46 (73.02 %), respectively. Operations were performed with open (1.0 %), laparoscopic (39.35 %) and robot-assisted (59.65 %) accesses. AKI was evaluated by the changes in serum creatinine and glomerular filtration rate before surgery and 1–3 days after in accordance with KDIGO criteria.Results. The overall incidence of AKI after surgical treatment for kidney cancer at stages cT1a–cT2a was 27.57 %. The incidence of AKI after RN was 65.04 %, after PN – 11.23 %. At stages cT1a, cT1b, cT2a, after nephron-sparing surgery and radical treatment, this indicator was 9.37; 11.11; 29.41 % and 71.43; 63.49; 65.22 %, respectively. For warm ischemia time below 15 and 20 minutes, AKI incidence did not exceed 8.3 and 13.2 %, respectively. For warm ischemia time >30 min, a dramatic increase in AKI incidence was observed.Conclusion. To preserve kidney function, PN is the operation of choice in surgical treatment of kidney tumors at stages cT1–cT2a. After RN, AKI development was observed 6 times more often than after PN. The following statistically significant predictors of AKI after PN were identified: presence of initial chronic kidney disease in patients, tumor size, operative time above 190 minutes, type of kidney ischemia used, and warm ischemia time above 25 minutes.
EUROPEAN OFFSHORE NETWORK WITH WIND POWER PLANTS
Authors: Kyryk Valerii , Shtefyrtsa Yelyzaveta 
Published: November 2023

Problems The growth of electricity consumption and the change in climatic conditions present society with the challenge of ensuring sustainable and ecologically clean electricity production. For many countries, especially in the European Union, the transition to sustainable and ecologically clean energy sources has become a priority.
Objective A general overview and analysis of trends in the development of the network of offshore wind power plants located in the open sea on the continental shelf of European countries
Methodology of implementation The strategy for the development of a single European offshore network with wind power plants was used for research. The study of the effectiveness and advantages of offshore power plants was carried out in the variability of the advanced countries of the European Union..
Results An overview of the electric power industry of European countries that pursue an active policy in the field of offshore energy is given. The statistics on the generation of wind energy, the number and development of wind turbines in Europe are given. The main projects that have been implemented or are in the process of preparation have been considered. An analysis of the measures introduced by the European Union to increase the use of wind energy and reduce dependence on traditional energy sources and achieve carbon neutrality was performed.
Conclusions The European offshore network with wind power plants has become an important component of sustainable energy development in the region. Statistics on the development of offshore wind energy indicate that European countries are actively working on the development of this sector, investing significant efforts and resources.
Acute Carpal Tunnel Syndrome from Horseshoe Abscess
Authors: Nguyen Matthew T. , Mejia Alfonso 
Published: November 2023

Case:
A 53-year-old man presented with a puncture wound to his right thumb, resulting in a horseshoe abscess, its infectious clinical picture muddled by dense paresthesias from the ensuing acute carpal tunnel syndrome. He was treated with irrigation and debridement of the thumb and small finger flexor tendon sheaths, carpal tunnel release, and bootlacing and dermal substitute application to the proximal forearm with eventual split-thickness skin grafting.

Conclusion:
Although a horseshoe abscess resulting in acute carpal tunnel syndrome is a rare entity unquantified in the literature, the treating orthopaedic surgeon should be aware of its association and initiate appropriate treatment accordingly.
State and Metropolitan Area Disparities in Long COVID-19 and Related Symptoms among US Adults, June-October 2022
Authors: Singh Gopal K. , Lee Hyunjung , Kim Lyoung Hee , Azuine Romuladus E. 
Published: November 2023

Background: Little research exists on sociodemographic and geographic inequalities in Long COVID, defined as COVID-19 symptoms lasting 3 months or longer. Using the latest nationally representative data, we examine geographic disparities in prevalence of Long COVID and severe COVID symptoms among United States (US) adults aged ≥18 years.
Methods: We analyzed five consecutive rounds of the US Census Bureau’s Household Pulse Survey from June 1 to October 17, 2022 (N=108,064). Using multivariable logistic regression and health disparity indices, we modeled disparities in Long COVID and severe COVID symptoms by state and metropolitan area, controlling for race/ethnicity, socioeconomic status, health insurance, and other demographic characteristics.
Results: During June–October 2022, an estimated 35.4 million or 32.2% of COVID patients in the US reported developing Long COVID; and 15.2 million or 13.8% of COVID patients reported experiencing severe COVID symptoms. The prevalence of Long COVID ranged from 24.0% in the District of Columbia (DC), 25.4% in Hawaii to 39.2% in Alabama, 39.9% in Wyoming, and 43.6% in West Virginia. Adjusted for covariates, adults with COVID-19 diagnosis in Alabama, Wyoming, and West Virginia had 48-178% higher adjusted odds of developing Long COVID than their counterparts in DC. Adults with COVID-19 diagnosis in Alabama, Arkansas, Colorado, Iowa, Kentucky, Mississippi, Montana, North Dakota, South Dakota,Texas, Utah, Virginia, Wyoming, and West Virginia had 2.0-2.5 times higher adjusted odds of experiencing severe COVID symptoms than their counterparts in Vermont. Large disparities in prevalence of Long COVID and severe COVID symptoms existed among the 15 largest metropolitan areas of the US, with the prevalence of Long COVID ranging from 21.9% in San Francisco to 38.0% in Riverside, California. Socioeconomic, demographic and health insurance characteristics explained 34% of the state-level disparity and 45% of the metropolitan-area disparity in Long COVID prevalence.
Conclusion and Implications for Translation: Marked geographic disparities existed, with COVID patients/survivors in the Southeast, Southwest, and Northern Plains states being at substantially higher risks of developing Long COVID and severe COVID symptoms. Equitable access to care and support services among patients with Long COVID is critical to reducing inequities in COVID-related healthoutcomes.

Copyright © 2023 Singh et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
Full Breit Hamiltonian in the Multiwavelets Framework
Authors: Tantardini Christian , Eikås Roberto Di Remigio , Bjørgve Magnar , Jensen Stig Rune , Frediani Luca 
Published: November 2023

Abstract
New techniques in core-electron spectroscopy are necessary to resolve the structures of oxides of f-elements and other strongly correlated materials that are present only as powders and not as single crystals.
Thus, accurate quantum chemical methods need to be developed to calculate core spectroscopic properties in such materials. In this contribution, we present an important development in this direction, extending our fully adaptive real-space multiwavelet basis framework to tackle the 4-component Dirac-Coulomb-Breit Hamiltonian.
We show that Multiwavelets are able to reproduce one-dimensional grid-based approaches. They are however a fully three-dimensional approach which can later on be extended to molecules and materials.
Our Multiwavelet implementation attained precise results irrespective of the chosen nuclear model, provided that the error threshold is tight enough and the chosen polynomial basis is sufficiently large.
Furthermore, our results confirmed that in two-electron species, the magnetic and Gauge contributions from s-orbitals are identical in magnitude and can account for the experimental evidence from K and L edges.
Observation of a bone invasion model of Aspergillus fumigatus in vitro and analysis of the antifungal susceptibility
Authors: Shao Yan , Shen Min , Peng Dan , Cheng Wenxu , Mao Chenggang , Zhang Heng , Sun Yi 
Published: November 2023

Abstract
Background Recently, the prevalence of invasive fungal infections has been on the rise, and one of the prevalent symptoms frequently observed is bone deterioration and bone loss.
Materials and Methods This study successfully established a bone invasion model of A. fumigatus in vitro using a 24-well plate. Pathological analysis was then employed to observe the structure and distinctive features of the invading fungal elements within the bone invasion model.Meanwhile, the antifungal effects of itraconazole, voriconazole, posaconazole, and amphotericin B were evaluated.
Results The pathological findings showed that in the experimental group, fungal spores and hyphae invaded the bone tissue or were observed growing in the vicinity of the bone edge tissues, as indicated by both HE and PAS staining. In contrast, no fungal elements were observed in the control group, indicating that the bone invasion model of A. fumigatus in vitro was successfully constructed. Furthermore, the findings from the antifungal sensitivity test demonstrated that the lowest effective concentrations of antifungal drugs against the bone invasion model were as follows: 4 μg/ml for itraconazole, 0.5 μg/ml for voriconazole, 2 μg/ml for posaconazole, and 2 μg/ml for amphotericin B.
Discussion The successful construction of the bone invasion model of A. fumigatus has provided a solid basis for future investigations into the mechanisms underlying A. fumigatus bone invasion and the study of its virulence factors. Utilizing bone models is of utmost importance in advancing the development of novel antifungal treatment approaches, as well as in effectively preventing and treating fungal bone invasion and osteolytic diseases.
Acute neural effects of the mood stabiliser lamotrigine on emotional processing in healthy volunteers - a randomised control trial
Authors: Martens Marieke , Zghoul Tarek , Watson Evie , Rieger Sebastian , Capitao Liliana , Harmer Catherine 
Published: November 2023

Abstract

Lamotrigine is an effective mood stabiliser, largely used for the management and prevention of depression in bipolar disorder. The neuropsychological mechanisms by which lamotrigine acts to relieve symptoms as well as its neural effects on emotional processing remain unclear. The primary objective of this current study was to investigate the impact of an acute dose of lamotrigine on the neural response to a well-characterised fMRI task probing implicit emotional processing relevant to negative bias. 31 healthy participants were administered either a single dose of lamotrigine (300mg, n = 14) or placebo (n = 17) in a randomized, double-blind design. Inside the 3T MRI scanner, participants completed a covert emotional faces gender discrimination task. Brain activations showing significant group differences were identified using voxel-wise GLM nonparametric permutation testing, with TFCE and an FWE-corrected cluster significance threshold of p < 0.05. Participants receiving lamotrigine were more accurate at identifying the gender of fearful (but not happy or angry) faces. A network of regions associated with emotional processing, including amygdala, insula, and the ACC, was significantly less activated in the lamotrigine group compared to the placebo group across emotional facial expressions. A single dose of lamotrigine reduced activation in limbic areas in response to faces with both positive and negative expressions, suggesting a valence-independent effect. However, at a behavioural level lamotrigine appeared to reduce the distracting effect of fear on face discrimination. Such effects may be relevant to the mood stabilisation effects of lamotrigine.
Clinical trials registration: NCT04396938