bluuebunny/crossref_metadata_2025_split huggingface dataset:
Let's talk about sex: Mechanisms of neural sexual differentiation in Bilateria
Authors: Roggenbuck Emma C. , Hall Elijah A. , Hanson Isabel B. , Roby Alyssa A. , Zhang Katherine K. , Alkatib Kyle A. , Carter Joseph A. , Clewner Jarred E. , Gelfius Anna L. , Gong Shiyuan , Gordon Finley R. , Iseler Jolene N. , Kotapati Samhita , Li Marilyn , Maysun Areeba , McCormick Elise O. , Rastogi Geetanjali , Sengupta Srijani , Uzoma Chantal U. , Wolkov Madison A. , Clowney E. Josephine 
Published: January 2024

AbstractIn multicellular organisms, sexed gonads have evolved that facilitate release of sperm versus eggs, and bilaterian animals purposefully combine their gametes via mating behaviors. Distinct neural circuits have evolved that control these physically different mating events for animals producing eggs from ovaries versus sperm from testis. In this review, we will describe the developmental mechanisms that sexually differentiate neural circuits across three major clades of bilaterian animals–Ecdysozoa, Deuterosomia, and Lophotrochozoa. While many of the mechanisms inducing somatic and neuronal sex differentiation across these diverse organisms are clade‐specific rather than evolutionarily conserved, we develop a common framework for considering the developmental logic of these events and the types of neuronal differences that produce sex‐differentiated behaviors.This article is categorized under:
Congenital Diseases > Stem Cells and Development
Neurological Diseases > Stem Cells and Development
Introduction
Authors: Jonker Gerdien , Schwaderer Isabella 
Published: January 2024

AbstractWith the focus on the interface between religion and art, this interdisciplinary volume addresses India as a trope of primaeval religiosity and imagined origins in Imperial Germany, the Weimar Republic, and national socialist Germany, respectively. The book covers the period from 1880 to 1945, but with historical expeditions going back to 1800. Placing the focus on religion, it traces forms of identity-making and nation-building processes involved in the German–Indian entanglement. As a result, the volume offers a global historical approach to religion from a modern transformative perspective.
The Indian Challenge: Indology and New Conceptions of Christianity as ‘Religion’ at the End of the Nineteenth Century
Authors: Thurner Mathias 
Published: January 2024

AbstractThis chapter argues that religion as a universal concept was not a European invention but had a global history. In the late-nineteenth century, a new understanding of ‘religion’(This contribution uses terms like ‘religion’, ‘science’, ‘history’, or ‘Europe’ not as ontological self-evident entities and unchangeable concepts. They are rather understood in a strictly historical sense—as names produced and used within a global discourse) emerged as a reaction against a physiological materialism that criticized ‘religion’ in the name of ‘science’. This new understanding regarded religion as an inner experience differing from ‘science’. Simultaneously, colonial knowledge production and the new importance of ‘history’ in the humanities led to the formation of a general religious history including Christianity. Consequently, religious reformers in all parts of the world started to define their traditions as ‘religion’ to prove their accordance with ‘science’. Western intellectuals were turning to Buddhism, and later a neo-Vedantic form of Hinduism, as decidedly scientific religions, and as historical evidence for their critique of Christianity. In this context, Christian theologians were challenged to prove the truth claims of Christianity in the new arena of the general religious history. Ernst Troeltsch, who was at the centre of this debate, turned to the German Indologist Hermann Oldenberg to substantiate his new conception of Christianity. This chapter shows that Troeltsch and Oldenberg were part of a global discourse on religion in which Buddhism was a challenge for Christian scholars.
Death and Transfiguration: Religion and Belonging in Felix Gotthelf’s Indian Opera Mahadeva (1910)
Authors: Schwaderer Isabella 
Published: January 2024

AbstractDoctor, composer, and Schopenhauer enthusiast Felix Gotthelf (1857–1930) created a symphonic dramaMahadeva(1910) in which he transformed a Goethe ballad into a religious–artistic manifesto. He combined Indian philosophy, as popularized by Paul Deussen, with Christianity and Schopenhauer’s philosophy. Inspired by Richard Wagner, he attempted an Indo-German national and religious revival in music based on a romantic conception of art and religion. It was in effect a conservative reorientation of a philosophical and artistic appropriation of Indian scriptures that betrayed attempts to establish the social ethos of the late German Empire as autochthonous and within the tradition of German intellectual and Reformation history. The author’s contribution is to examine the interconnections between religion, national revival, and music in the context of widespread cultural criticism shortly before the First World War.
Modernism in Disguise? Neglected Aspects of the So-Called Revival of a Classical Indian Dance Form
Authors: Schlage Sandra Jasmin 
Published: January 2024

AbstractContact with remote cultures in the late nineteenth and early twentieth centuries stimulated major changes in the art practices of India and Western countries such as Germany. In this chapter, Sandra Jasmin Schlage analyses the knowledge production emanating from these developments with a special emphasis on applying terms and concepts like ‘revival’, or the emergence of ‘modernism’. The most exalted discourse from India is the so-called ‘revival’ of the classical dance traditions exemplified by Bharatanāṭyam from Southeast India. This chapter provides a critical analysis of this process through a comparison with the emergence of the so-called modern dance in Western countries, on the one hand, and the contemporary rise of modern visual arts in India, on the other hand. Some striking similarities have led the author to question the labelling of these developments and to suggest that the ‘revival’ of classical Indian dance traditions contains some ‘modernism’ in disguise.
‘The Priestess of Hindu Dance’: Leila Sokhey’s Repertoire and Its Reception in the Netherlands and Germany (1927–38)
Authors: Kanhai Parveen 
Published: January 2024

AbstractLeila Sokhey, who became known as Madame Menaka, is recognized as a protagonist in the so-called Indian dance revival of 1923–47. Her dance embodied a marked ambivalence, for while it was part of a nationalist cultural endeavour, it was soundly grounded in a Western form of the aesthetics of Oriental dance. A variety of sources indicate that this stemmed from her own hybrid identity, as well as from her wish to fulfil the expectations of European audiences. Her art was considered ancient and deeply spiritual in the Netherlands and Germany. Prominent Dutch reviewers considered themselves knowledgeable about Hindu religious dance and suggested that its most authentic form existed in the colonial Dutch Indies rather than in India, whereas German reviewers adhered to and propagated the national socialist ideology and construction of India. Nonetheless, critics questioned whether it was possible to comprehend dance fully from a fundamentally different cultural tradition.
Surveying the Landscape: The Oil Industry and Alternative Energy in the 1970s
Authors: Mody Cyrus C. M. 
Published: January 2024

AbstractThe multi-level perspective (MLP) is one of the most widely-used frameworks for understanding the conditions and choices underpinning energy transitions. Although this volume contains several cogent critiques of the concept of an energy transition, it is still important for historians to be able to address the transitions studies community on its terms—which means being able to convey our historical cases in the language of MLP. At the same, we can use the rich and ambiguous historical record to point out—and possibly correct—shortcomings in the MLP framework. In this chapter I show that MLP’s vocabulary offers useful heuristics for understanding the energy debates of the 1970s—the “landscape” changes that destabilized the fossil fuel “regime” and stimulated alternatives such as solar and nuclear to “break out” from their “niches.” However, I show that the oil industry’s role in the 1970s debates complicates the MLP framework, in that the era’s most important landscape shifts were not exogenous to the oil industry, while oil firms exerted substantial control over niche alternatives. By the mid-1980s, the fossil fuel regime re-stabilized and alternative energy technologies were forced into even smaller niches than before—a reversal that is in tension with the more optimistic and linear stories usually found in transitions studies.
Flat F-theory and friends
Authors: Cheng Peng , Melnikov Ilarion V. , Minasian Ruben 
Published: January 2024

Abstract
We discuss F-theory backgrounds associated to flat torus bundles over Ricci-flat manifolds. In this setting the F-theory background can be understood as a IIB orientifold with a large radius limit described by a supersymmetric compactification of IIB supergravity on a smooth, Ricci flat, but in general non-spin geometry. When compactified on an additional circle these backgrounds are T-dual to IIA compactifications on smooth non-orientable manifolds with a Pin− structure.
Complete $$ {N}_f^2 $$ contributions to four-loop pure-singlet splitting functions
Authors: Gehrmann Thomas , von Manteuffel Andreas , Sotnikov Vasily , Yang Tong-Zhi 
Published: January 2024

Abstract
The scale evolution of parton distributions is determined by universal splitting functions. As a milestone towards the computation of these functions to four-loop order in QCD, we compute all contributions to the pure-singlet quark-quark splitting functions that involve two closed fermion loops. The splitting functions are extracted from the pole terms of off-shell operator matrix elements, and the workflow for their calculation is outlined. We reproduce known results for the non-singlet four-loop splitting functions and validate our new pure-singlet results against fixed Mellin moments.
Versorgung von Choanalatresien in Deutschland
Authors: Yılmaz Topçuoğlu Miray-Su , Hammitsch-Mayer Antje , Plinkert Peter K. , Baumann Ingo 
Published: January 2024

Zusammenfassung
Hintergrund
Verschiedene chirurgische Techniken mit transpalatinalen, transseptalen und transnasalen Zugängen zur operativen Therapie der Choanalatresie wurden in den letzten 200 Jahren entwickelt. Die endoskopische endonasale Chirurgie mit dorsaler Septumresektion und ohne Stents ist der aktuelle wissenschaftliche Trend, da so hohe Erfolgsraten mit geringen Komplikationsraten erreicht werden können. Diese Studie untersuchte, ob sich diese Technik tatsächlich flächendeckend in Deutschland durchgesetzt hat und welche Rolle die Anwendung von Stents hierbei spielt.

Methoden
Insgesamt 52 Hals-Nasen-Ohren(HNO)-Kliniken in Deutschland, davon alle 39 HNO-Universitätskliniken und 13 nicht-universitäre HNO-Kliniken der Maximalversorgung, wurden befragt, welche chirurgische Technik sie für die Choanalatresieresektion verwenden und ob Stents zum Einsatz kommen.

Ergebnisse
Für die dorsale Septumresektion gaben 39 von 44 antwortenden Kliniken (89 %) an, dorsale Septumteile zu resezieren. Bei den Universitätskliniken lag der Anteil bei 85 %, bei den nicht-universitären Kliniken bei 100 %.
Für die Anwendung von Stents gaben 20 von 48 antwortenden Kliniken (42 %) an, keine Stents zu verwenden. Bei den Universitätskliniken lag der Anteil bei 39 %, bei den nicht-universitären Kliniken bei 50 %.

Schlussfolgerung
Die endoskopische endonasale Choanalatresieresektion mit dorsaler Septumresektion wird in den großen HNO-Kliniken Deutschlands größtenteils als Standardtechnik verwendet. Die routinemäßige Verwendung von Stents ist noch weit verbreitet. Die Reduktion der Stentnutzung in der Choanalatresieversorgung und die Verwendung dieser Methode nur in schwierigen Einzelfällen sollte künftiges Ziel sein.
Deep Conservation and Unexpected Evolutionary History of Neighboring lncRNAs MALAT1 and NEAT1
Authors: Weghorst Forrest , Torres Marcén Martí , Faridi Garrison , Lee Yuh Chwen G. , Cramer Karina S. 
Published: January 2024

AbstractLong non-coding RNAs (lncRNAs) have begun to receive overdue attention for their regulatory roles in gene expression and other cellular processes. Although most lncRNAs are lowly expressed and tissue-specific, notable exceptions include MALAT1 and its genomic neighbor NEAT1, two highly and ubiquitously expressed oncogenes with roles in transcriptional regulation and RNA splicing. Previous studies have suggested that NEAT1 is found only in mammals, while MALAT1 is present in all gnathostomes (jawed vertebrates) except birds. Here we show that these assertions are incomplete, likely due to the challenges associated with properly identifying these two lncRNAs. Using phylogenetic analysis and structure-aware annotation of publicly available genomic and RNA-seq coverage data, we show that NEAT1 is a common feature of tetrapod genomes except birds and squamates. Conversely, we identify MALAT1 in representative species of all major gnathostome clades, including birds. Our in-depth examination of MALAT1, NEAT1, and their genomic context in a wide range of vertebrate species allows us to reconstruct the series of events that led to the formation of the locus containing these genes in taxa from cartilaginous fish to mammals. This evolutionary history includes the independent loss of NEAT1 in birds and squamates, since NEAT1 is found in the closest living relatives of both clades (crocodilians and tuataras, respectively). These data clarify the origins and relationships of MALAT1 and NEAT1 and highlight an opportunity to study the change and continuity in lncRNA structure and function over deep evolutionary time.
Application of novel burst wave lithotripsy and ultrasonic propulsion technology for the treatment of ureteral calculi in a bottlenose dolphin (Tursiops truncatus) and renal calculi in a harbor seal (Phoca vitulina)
Authors: Holmes Arturo E. , Chew Ben H. , Laughlin Robert , Buckley Jean , Kiewice Erica , Dancel Michael J. , Blasko David , Wong Victor K. F. , Halawani Abdulghafour , Koo Kyo Chul , Corl Doug , Fasolo Paul , Levy Oren , Thiel Jeff , Bailey Michael R. , Eichman Jammy , Meegan Jennifer M. , Haulena Martin 
Published: January 2024

AbstractMarine mammals may develop kidney stones, which can be challenging to treat. We describe burst wave lithotripsy (BWL) and ultrasonic propulsion to treat ureteral calculi in a 48-year-old female bottlenose dolphin (Tursiops truncatus) and to reduce renal stone burden in a 23-year-old male harbor seal (Phoca vitulina). BWL and ultrasonic propulsion were delivered transcutaneously in sinusoidal ultrasound bursts to fragment and reposition stones. Targeting and monitoring were performed with real-time imaging integrated within the BWL system. Four dolphin stones were obtained and fragmented ex vivo. The dolphin case received a 10-min and a 20-min BWL treatment conducted approximately 24 h apart to treat two 8–10 mm partially obstructing right mid-ureteral stones, using oral sedation alone. For the harbor seal, while under general anesthesia, retrograde ureteroscopy attempts were unsuccessful because of ureteral tortuosity, and a 30-min BWL treatment was targeted on one 10-mm right kidney stone cluster. All 4 stones fragmented completely to < 2-mm fragments in < 20 min ex vivo. In the dolphin case, the ureteral stones appeared to fragment, spread apart, and move with ultrasonic propulsion. On post-treatment day 1, the ureteral calculi fragments shifted caudally reaching the ureteral orifice on day 9. On day 10, the calculi fragments passed, and the hydroureter resolved. In the harbor seal, the stone cluster was observed to fragment and was not visible on the post-operative computed tomography scan. The seal had gross hematuria and a day of behavior indicating stone passage but overall, an uneventful recovery. BWL and ultrasonic propulsion successfully relieved ureteral stone obstruction in a geriatric dolphin and reduced renal stone burden in a geriatric harbor seal.
Mixed stones: urinary stone composition, frequency and distribution by gender and age
Authors: Siener Roswitha , Rüdy Jakob , Herwig Helena , Schmitz Marie-Therese , Schaefer Reinhold M. , Lossin Philipp , Hesse Albrecht 
Published: January 2024

AbstractProper analysis of urinary stone composition is a cornerstone for diagnosis, targeted treatment and recurrence prevention of urolithiasis. The aim of this study was to determine the composition, frequency and distribution of mixed stones according to gender and age of patients. A total of 42,519 urinary stones from 30,311 men and 12,208 women submitted between January 2007 and December 2020 were studied. Most urinary calculi consisted of two components (50.9%), followed by stones of a single constituent (27.1%) and three-component stones (21.9%), while four-component stones were only rarely identified (0.1%). Among all stones, 49.8% consisted of whewellite (COM), weddellite (COD), and mixtures of COM and COD, 33.8% were pure carbonate apatite (CA) and mixtures of CA with COM and/or COD, while 7.6% were composed of uric acid anhydrous (UAA), uric acid dihydrate (UAD), and mixed UAA and UAD. The remaining 8.8% of calculi were rare single-component stones and rare mixtures of various constituents. The number of stone components was inversely associated with age (p < 0.001). The proportion of men decreased significantly with the number of stone constituents, from 3.01:1 for single-component stones to 1.0:1 for four-component urinary calculi (p < 0.001). The vast majority of urinary calculi consisted of two or more components in varying proportions. While age was inversely associated with the number of stone constituents, the proportion of women increased significantly from single-component to four-component urinary calculi. A significant proportion of mixed stones could present a challenge for diagnosis and targeted recurrence prevention.
Hydrolysis of ionic liquid–treated substrate with an Iocasia fonsfrigidae strain SP3-1 endoglucanase
Authors: Heng Sobroney , Sutheeworapong Sawannee , Wangnai Chinnapong , Champreda Verawat , Kosugi Akihiko , Ratanakhanokchai Khanok , Tachaapaikoon Chakrit , Ceballos Ruben Michael 
Published: January 2024

Abstract
Recently, we reported the discovery of a novel endoglucanase of the glycoside hydrolase family 12 (GH12), designated IfCelS12A, from the haloalkaliphilic anaerobic bacterium Iocasia fonsfrigidae strain SP3-1, which was isolated from a hypersaline pond in the Samut Sakhon province of Thailand (ca. 2017). IfCelS12A exhibits high substrate specificity on carboxymethyl cellulose and amorphous cellulose but low substrate specificity on b-1,3;1,4-glucan. Unlike some endoglucanases of the GH12 family, IfCelS12A does not exhibit hydrolytic activity on crystalline cellulose (i.e., Avicel™). High-Pressure Liquid Chromatography (HPLC) and Thin Layer Chromatography (TLC) analyses of products resulting from IfCelS12-mediated hydrolysis indicate mode of action for this enzyme. Notably, IfCelS12A preferentially hydrolyzes cellotetraoses, cellopentaoses, and cellohexaoses with negligible activity on cellobiose or cellotriose. Kinetic analysis with cellopentaose and barely b-d-glucan as cellulosic substrates were conducted. On cellopentaose, IfCelS12A demonstrates a 16-fold increase in activity (KM = 0.27 mM; kcat = 0.36 s−1; kcat/KM = 1.34 mM−1 s−1) compared to the enzymatic hydrolysis of barley b-d-glucan (KM: 0.04 mM, kcat: 0.51 s−1, kcat/KM = 0.08 mM−1 s−1). Moreover, IfCelS12A enzymatic efficacy is stable in hypersaline sodium chlorids (NaCl) solutions (up to 10% NaCl). Specifically, IfCel12A retains notable activity after 24 h at 2M NaCl (10% saline solution). IfCelS12A used as a cocktail component with other cellulolytic enzymes and in conjunction with mobile sequestration platform technology offers additional options for deconstruction of ionic liquid–pretreated cellulosic feedstock.

Key points
• IfCelS12A from an anaerobic alkaliphile Iocasia fronsfrigidae shows salt tolerance
• IfCelS12A in cocktails with other enzymes efficiently degrades cellulosic biomass
• IfCelS12A used with mobile enzyme sequestration platforms enhances hydrolysis
Endolysin EN572-5 as an alternative to treat urinary tract infection caused by Streptococcus agalactiae
Authors: Kajsikova Maria , Kajsik Michal , Bocanova Lucia , Papayova Kristina , Drahovska Hana , Bukovska Gabriela 
Published: January 2024

Abstract
Streptococcus agalactiae (Group B Streptococcus, GBS) is an opportunistic pathogen causing urinary tract infection (UTI). Endolysin EN572-5 was identified in prophage KMB-572-E of the human isolate Streptococcus agalactiae KMB-572. The entire EN572-5 gene was cloned into an expression vector and the corresponding recombinant protein EN572-5 was expressed in Escherichia coli in a soluble form, isolated by affinity chromatography, and characterized. The isolated protein was highly active after 30 min incubation in a temperature range of − 20 °C to 37 °C and in a pH range of 5.5–8.0. The endolysin EN572-5 lytic activity was tested on different Streptococcus spp. and Lactobacillus spp. The enzyme lysed clinical GBS (n = 31/31) and different streptococci (n = 6/8), and also exhibited moderate lytic activity against UPEC (n = 4/4), but no lysis of beneficial vaginal lactobacilli (n = 4) was observed. The ability of EN572-5 to eliminate GBS during UTI was investigated using an in vitro model of UPSA. After the administration of 3 μM EN572-5, a nearly 3-log decrease of urine bacterial burden was detected within 3 h. To date, no studies have been published on the use of endolysins against S. agalactiae during UTI.

Key points
• A lytic protein, EN572-5, from a prophage of a human GBS isolate has been identified.
• This protein is easily produced, simple to prepare, and stable after lyophilization.
• The bacteriolytic activity of EN572-5 was demonstrated for the first time in human urine.

Graphical abstract
Characterization and stabilization of GluLm and its application to deglycosylate dietary flavonoids and lignans
Authors: Curiel José Antonio , de la Bastida Ana Ruiz , Langa Susana , Peirotén Ángela , Landete José María 
Published: January 2024

Abstract
This study describes the characterization of the recombinant GH3 aryl-β-glucosidase “GluLm” from Limosilactobacillus mucosae INIA P508, followed by its immobilization on an agarose support with the aim of developing an efficient application to increase the availability and concentration of flavonoid and lignan aglycones in a vegetal beverage. In previous studies, heterologous GluLm-producing strains demonstrated a great capacity to deglycosylate flavonoids. Nevertheless, the physicochemical properties and substrate spectrum of the enzyme remained unknown up to now. A high production of purified GluLm was achieved (14 mg L−1). GluLm exhibited optimal activity at broad ranges of pH (5.0–8.0) and temperature (25–60°C), as well as high affinity (Km of 0.10 mmol L−1) and specific constant (86554.0 mmol L−1 s−1) against p-nitrophenyl-β-D-glucopyranoside. Similar to other GH3 β-glucosidases described in lactic acid bacteria, GluLm exhibited β-xylosidase, β-galactosidase, and β-fucosidase activities. However, this study has revealed for the first time that a GH3 β-glucosidase is capable to hydrolyze different families of glycosylated phenolics such as flavonoids and secoiridoids. Although it exhibited low thermal stability, immobilization of GluLm improved its thermostability and allowed the development of a beverage based on soybeans and flaxseed extract with high concentration of bioactive isoflavone (daidzein, genistein), lignan (secoisolariciresinol, pinoresinol, and matairesinol), and other flavonoid aglycones.

Key points
• Limosilactobacillus mucosae INIA P508 GluLm was purified and biochemically characterized
• Immobilized GluLm efficiently deglycosylated flavonoids and lignans from a vegetal beverage
• A viable application to produce vegetal beverages with a high content of aglycones is described