bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitroandin VivoAntimalarial Activity, Cytotoxicity and Phytochemical HRMS2Profile of Plants from the Western Pará State, Brazilian Amazonia
Authors: Viana dos Santos Maria Beatriz , Costa Gontijo Douglas , Alves do Nascimento Maria Fernanda , de Paula Renata Cristina , Bezerra Bellei Jessica Correia , Raimundo Felipe Oliveira , Gorza Scopel Kézia Katiani , de Oliveira Alaíde Braga , Veras Mourão Rosa Helena 
Published: November 2023

AbstractEthnopharmacology and botanical taxonomy are valid criteria used to selecting plants for antimalarial bioprospection purposes. Based on these two criteria, ethanol extracts of 11 plants from Santarém City vicinities, Western Pará State, Brazilian Amazonia, had theirin vitroantiplasmodial activity against chloroquine‐resistantPlasmodium falciparum(W2 clone) assessed by thePfLDH method, whereas their cytotoxicity to HepG2‐A16 cells was assessed through MTT assay.Acmella oleracea,Siparuna krukoviiandTrema micranthaextracts disclosed the highest rate of parasite growth inhibition (90 %) in screening tests.In vivoantimalarial assays were conducted with these extracts againstPlasmodium berghei(NK 65 strain) infected mice. Inhibition rate of parasite multiplication ranged from 41.4 % to 60.9 % at the lowest extract dose (25 mg/kg). HPLC‐ESI‐HRMS2analyses allowed the putative identification of alkylamides, fatty acids, flavonoid glycosides and alkaloids in ethanol extracts deriving from these three plant species. Results pointed towardsA. oleraceaflowers ethanol extract as the most promising potential candidate to preclinical studies aiming the development of antimalarial phytomedicine.
Green Synthesis of CuO Nanoparticles UsingAgaricus bisporusExtract as a Highly Efficient Catalyst for the Suzuki Cross‐Coupling Reaction
Authors: İnce Simay , Yalçın M. Serkan , İnce Tuncay , Geçgel Cihan , Yılmaz Mustafa Kemal 
Published: November 2023

AbstractCopper oxide nanoparticles (CuONPs) were synthesized using a rapid, eco‐friendly, cost‐effective, efficient, and biological method employing aqueousAgaricus bisporusextract as a capping and reducing agent. The formation of CuONPs was checked by UV‐vis spectroscopy and was characterized by X‐ray diffraction analysis (XRD), dynamic light scattering spectroscopy (DLS), transmission electron microscopy (TEM), and surface area and porosimetry analyzer. The characterization results showed that the synthesized nanoparticles had a spherical‐like appearance and a crystal structure with 40–100 nm particle size. The green synthesized CuONPs were found to be an excellent and sustainable heterogeneous catalyst (TOF up to 29700 h−1) for the Suzuki C−C coupling of aryl halides with phenylboronic acid in a very short reaction time (10 minutes). Moreover, the easily recovered catalyst can be reused five times with just a negligible reduction in catalytic behavior.
Attenuative effects of tamarixetin against polystyrene microplastics‐induced hepatotoxicity in rats by regulation of Nrf‐2/Keap‐1 pathway
Authors: Ijaz Muhammad Umar , Khalil Mehrab , Hamza Ali , Khatoon Aisha 
Published: November 2023

AbstractPolystyrene microplastics (PS‐MPs) are environmental contaminants due to their potential to induce damages in multiple organs specifically liver. Tamarixetin (TMT) is a naturally occurring flavonoid present in Tamarix ramosissima plant that exhibits multiple pharmacological properties. Therefore, the present research was designed to evaluate the palliative role of TMT against PS‐MPs instigated liver dysfunction in rats. The exposure to PS‐MPs reduced the expressions of nuclear factor erythroid 2‐related factor 2 and antioxidant genes, while increasing the expression of Kelch‐like ECH‐associated protein 1. PS‐MPs exposed rats exhibited considerably (p < .05) higher alkaline phosphatase (ALP), aspartate aminotransferase (AST) as well as alanine aminotransferase (ALT) contents. Additionally, PS‐MPs treatment resulted in a notable decrease in anti‐oxidants activity, that is, glutathione S‐transferase (GST), superoxide dismutase (SOD), heme oxygenase‐1 (HO‐1), glutathione reductase (GSR), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) content, whereas upregulating reactive oxygen species (ROS) and malondialdehyde (MDA) contents. Moreover, PS‐MPs intoxication noticeably increased (p < .05) the inflammatory indices (interleukin‐1ß [IL‐1ß], nuclear factor kappa B [NF‐κB], interleukin‐6 [IL‐6], tumor necrosis factor‐α [TNF‐α] levels, and cyclooxygenase‐2 [COX‐2] activity). Besides, Caspase‐3 and Bax expressions were upregulated and Bcl‐2 expression was decreased after PS‐MPs exposure. Additionally, the histomorphological examination revealed notable hepatic damage in PS‐MPs treated group. However, TMT treatment substantially (p < .05) recovered all the PS‐MPs‐induced damages and histopathological changes. Taken together, it can be deduced that TMT might be used as a pharmacological agent to ameliorate hepatic damage.
The protective effect of aqueous extract ofStevia rebaudianaagainst tartrazine toxicity in male Wistar rat
Authors: Hanna Demiana H. , Beshay Sylvia Nabil , El. Shafee E. , El‐Rahman Heba Ali Abd 
Published: November 2023

AbstractTartrazine is a yellow colouring agent that is commonly used in foods; however, high dosages of Tartrazine affect fertility and create oxidative stress by generating free radicals. A plant species known asStevia rebaudianahas natural antioxidants that show promise for protecting testicular tissue. Consequently, this study was intended to examine the ameliorative effect of the aqueous extract ofS. rebaudiana(Stevia) on the fertility of male Wistar rats induced by the daily oral intake of Tartrazine. Utilizing gas chromatography–mass spectrometry, phytochemical identification was accomplished forSteviaextract. Study groups were separated into several groups: the first group (the control) got distilled water for up to 56 days; theSteviagroup (1000 mg/kg), the Tartrazine group (300 mg/kg) and theSteviaand Tartrazine group (the group was given Tartrazine after 1 h ofSteviaextract intake). Also, the oxidative damage in testicular tissues was assessed by measuring the levels of malondialdehyde (MDA) and antioxidants (catalase [CAT], superoxide dismutase [SOD] and glutathione reductase [GSH]). Further, histological alterations were examined. In addition, cyclic AMP‐responsive element modulator (Crem)gene expression levels and their relative proteins were measured in the testicular tissues using quantitative real‐time polymerase chain reaction and enzyme‐linked immunosorbent assays, respectively. Sperm analysis and testosterone concentration were also performed. SPSS version 25 was used for the analysis of results while (p < .05) was regarded as significant. Compared with the control group, the results demonstrated that Tartrazine caused a significant reduction (p < .05) in the testosterone hormone level (0.70 ± 0.21) and the Crem protein quantity (1.21 ± 0.23) in the treated Tartrazine group. Also, it had a significant decrease (p < .05) in sperm motility, viability, count and antioxidant levels. Moreover, there was a significant increase (p < .05) in sperm abnormalities, MDA level (7.40 ± 1.10), kidney and liver function parameters, and DNA degradation in the treated Tartrazine group compared with the control group. On the contrary, theSteviaextract intake enhanced the testosterone (2.50 ± 0.60), antioxidants and Crem protein levels (2.33 ± 0.10) with an improvement in sperm quality in theSteviaand Tartrazine‐treated group compared with the Tartrazine group.Steviaalso caused a significant decrease (p < .05) in the MDA level (3.20 ± 0.20), and sperm abnormalities with an enhancement of the liver and kidney function parameters in theSteviaand Tartrazine‐treated group compared to the Tartrazine group.Steviaadministration has a protective effect on the testicular tissues and sperm quality against toxicity induced by Tartrazine exposure, so it will be a good antioxidant drug to be administered daily before daily administration of Tartrazine.
Metabolic signals influence cell‐fate decisions in Dictyostelium discoideum
Authors: Fatima Tasneem , Hadem Ibanylla Kynjai Hynniewta , Saran Shweta 
Published: November 2023

AbstractNutrient‐sensing plays a crucial role in maintaining cellular energy and metabolic homeostasis. Perturbations in sensing pathways are associated with a wide variety of pathologies, especially metabolic diseases. Very little is understood about sensing fluctuations in nutrients and how this information is integrated into physiological and metabolic adaptation that could further affect cell‐fate decisions during differentiation in Dictyostelium discoideum (henceafter, Dictyostelium). Glucose is the primary metabolic fuel among all nutrients. Carbohydrates, lipids and proteins ultimately breakdown into glucose, which is further used for providing energy. The maintenance of optimum glucose levels is important for efficient cell‐survival. Glucose is not only a nutrient, but also a signaling molecule influencing cell growth and differentiation in Dictyostelium. Modulation of endogenous glucose levels either by varying exogenous glucose levels or genetic overexpression or deletion of genes involved in glucose signaling lead to changes in endogenous metabolite levels such as ADP/ATP ratio, NAD+/NADH ratio, cAMP and ROS levels which further influence cell‐fate decisions. Here, we show that AMPKα and Sir2D are components of glucose‐signaling pathway in Dictyostelium which adjust cell metabolism interdependently in response to nutrient‐status and promote cell‐fate decisions.
Effect of Modification Strategies on the Biological Activity of Peptides/Proteins
Authors: Ma Jian , Yan Liang , Yang Jingkui , He Yujian , Wu Li 
Published: November 2023

AbstractCovalent attachment of biologically active peptides/proteins with functional moieties is an effective strategy to control their biodistribution, pharmacokinetics, enzymatic digestion, and toxicity. This review focuses on the characteristics of different modification strategies and their effects on the biological activity of peptides/proteins and illustrates their relevant applications and potential.
TAC‐tics for Leveraging Proximity Biology in Drug Discovery
Authors: Nalawansha Dhanusha A. , Mangano Kyle , den Besten Willem , Potts Patrick Ryan 
Published: November 2023

AbstractChemically induced proximity (CIP) refers to co‐opting naturally occurring biological pathways using synthetic molecules to recruit neosubstrates that are not normally encountered or to enhance the affinity of naturally occurring interactions. Leveraging proximity biology through CIPs has become a rapidly evolving field and has garnered considerable interest in basic research and drug discovery. PROteolysis TArgeting Chimera (PROTAC) is a well‐established CIP modality that induces the proximity between a target protein and an E3 ubiquitin ligase, causing target protein degradation via the ubiquitin‐proteasome system. Inspired by PROTACs, several other induced proximity modalities have emerged to modulate both proteins and RNA over recent years. In this review, we summarize the critical advances and opportunities in the field, focusing on protein degraders, RNA degraders and non‐degrader modalities such as post‐translational modification (PTM) and protein‐protein interaction (PPI) modulators. We envision that these emerging proximity‐based drug modalities will be valuable resources for both biological research and therapeutic discovery in the future.
Acute pancreatitis associated with the antibiotic levofloxacin: A rare case report
Authors: Inban Pugazhendi , Gulla Virali , Devani Aarfa , Akuma Chinaza Mercy , Gowthavaram Chengala Ananyaa , Hussain Akbar , Aung Lynn Lat Lat , Jadav Neel , Savaliya Bansi , Sajjad Taha , Khan Aadil Mahmood , Akuma Ogbonnaya , Kelechi Anasonye Emmanuel 
Published: November 2023

Key Clinical MessageDrug‐induced acute pancreatitis is a potentially ignored diagnosis that must be precisely valued. Drug‐induced acute pancreatitis can be considered the third common cause of acute pancreatitis after ruling out alcohol and gallstones. Levofloxacin belongs to a class of fluoroquinolone antibiotics used for treating various infections. Besides photosensitivity and liver toxicity, levofloxacin can induce acute pancreatitis, although rarely described. We highlight a case of acute pancreatitis in a female induced by levofloxacin. She presented with typical signs and symptoms of acute pancreatitis and had been taking levofloxacin for urinary tract infections for the last 3 days. After ruling out all other possible causes, her clinical picture, laboratory results, and imaging findings confirmed acute pancreatitis induced by levofloxacin.
Venoarterial extracorporeal membrane oxygenation in combination with Levosimendan as a bridge to recovery for a case of severe yew intoxication in a 13‐year‐old patient
Authors: Peer Eva Maria , Quitt Jonas , Marsch Stephan , Loosen Gregor 
Published: November 2023

Key Clinical MessageIn an adolescent patient with severe yew intoxication and consecutive cardiac arrest, non‐responsive to conventional resuscitation necessitating extracorporeal life support, Levosimendan has been implemented in the early acute phase of hemodynamic stabilization, without obvious side effects. However, the additive value of this treatment in severe yew intoxication remains speculative.
Successful treatment with nivolumab in a patient with unresectable oral squamous cell carcinoma following ineffective chemoradiotherapy
Authors: Sekido Katsuhisa , Imaue Shuichi , Tachinami Hidetake , Tomihara Kei , Naruto Norihito , Yamagishi Kentaro , Ikeda Atsushi , Fujiwara Kumiko , Noguchi Makoto 
Published: November 2023

Key clinical messageNivolumab has been clinically successful in prolonging the overall survival of patients with recurrent and metastatic head and neck cancer, complete remission is rare. Synergistic combinations of immunotherapy and conventional cancer treatments, such as radiotherapy or chemotherapy, are likely to be the most viable strategies for improving patient responses.AbstractImmune checkpoint inhibitors have revolutionized recurrent, metastatic oral cancer treatment; however complete remission in advanced stages is unusual. We present a case of complete remission of advanced oral squamous cell carcinoma for >4 years in a 64‐year‐old Japanese woman, that responded poorly to chemoradiotherapy but well to subsequent nivolumab treatment.
Congenital staphylococcal scalded skin syndrome in a preterm infant
Authors: Lee Ting‐Yu , Liu Tzu‐Yu 
Published: November 2023

Key Clinical MessageStaphylococcal scalded skin syndrome (SSSS) is a rare condition in premature infants. We report a case of SSSS in a preterm neonate who displayed all clinical manifestations at birth, leading to a fatal outcome from Candida parapsilosis fungemia. The clinical presentation was challenging to differential diagnosis. SSSS diagnosis was confirmed by skin biopsy. This case emphasizes the significance of early recognition and diagnosis of SSSS promptly for clinicians. Congenital SSSS in premature infants can be fatal, but with early recognition and appropriate supportive and antimicrobial therapy, outcomes can be improved and lives can be saved.
Two cases of neglected leishmaniasis with marked facial disfigurement: A diagnostic conundrum
Authors: Aryanian Zeinab , Balighi Kamran , Mohaghegh Fatameh , Etesami Ifa , Razavi Zahra , Hatami Parvaneh 
Published: November 2023

Key Clinical MessageThere is a need to pay more attention to cutaneous leishmaniasis in endemic regions which may mimic other dermatoses and treatment should be initiated with a strong clinical suspicion even without any histopathologic or PCR confirmation to avoid disfigurement or development of secondary malignancy.AbstractLeishmaniasis is a vector‐borne disease with a variety of Clinical manifestations. Cutaneous leishmaniasis (CL) is the most common form of disease and can mimic other dermatoses. We describe two unusual cases of chronic leishmaniasis that remained undiagnosed for many years and led to superimposition of squamous cell carcinoma (SCC) on lesions of one patient. These reports showed that the leishmaniasis should be borne in mind by clinicians when encountering any infiltrated lesion in patients from endemic regions and treatment should be initiated with a strong clinical suspicion even without any histopathologic or PCR confirmation to avoid disfigurement or development of secondary malignancy.
Wandering spleen; a rare clinical presentation of chronic pain with acute torsion
Authors: Ghasemi Shahab , Najari Dorsa , Mirhosseini Mohammadmoein , Refaei Meisam 
Published: November 2023

Key Clinical MessageWandering spleen results from abnormal ligamentous laxity and is often symptomatic, presented with abdominal pain and other non‐specific symptoms. These symptoms, make the diagnosis very difficult and most of the times even impossible. As such, keeping in mind this pathology, can make further complications less frequent.
Remote intracerebral hemorrhage following craniotomy for an intracerebral hematoma: A case report
Authors: Scalia Gianluca , Silven Manikon Poullay , Costanzo Roberta , Chaurasia Bipin , Furnari Massimo , Iacopino Domenico Gerardo , Nicoletti Giovanni Federico , Umana Giuseppe Emmanuele 
Published: November 2023

Key Clinical MessageRemote intracerebral hemorrhage (RICH) is a rare yet highly consequential complication that can occur after a craniotomy performed for the evacuation of an intracerebral hemorrhage (ICH). In this case report, we present the clinical details of a 74‐year‐old female patient who underwent a supratentorial craniotomy to address an ICH, and subsequently developed RICH. A 74‐year‐old woman was admitted to our department with a severe headache, onset of dysarthria, and left‐sided brachio‐crural hemiparesis. The patient had a history of arterial hypertension and a previous cerebral ischemia incident 2 years prior, potentially due to cerebral amyloid angiopathy. Despite the immediate surgical intervention and intensive care, she succumbed to respiratory distress after developing a contralateral ICH. RICH following craniotomy for an intracerebral hematoma is a rare but potentially devastating complication. Close monitoring, prompt recognition of neurological deterioration, and timely intervention are imperative to optimize patient outcomes. Further research is needed to better understand the underlying mechanisms and risk factors associated with this complication, allowing for improved prevention and management strategies in the future.
Modeling and Simulation of N‐(3‐Aminio‐4 methylphenyl)benzamide Synthesis in a Microreactor
Authors: Cao Yan , Ghadiri Mahdi 
Published: November 2023

AbstractN‐(3‐Amino‐4‐methylphenyl)benzamide is an intermediate product for the production of several medicines. Microreactor technology is a new concept for the continuous synthesis of chemicals. The computational fluid dynamics method was used to simulate the flow synthesis of N‐(3‐amino‐4‐methylphenyl)benzamide. There was good agreement between experimental data and modeling outputs. The effect of operating parameters such as temperature and residence time on system performance was investigated. The results revealed that an increase in temperature from 30 to 70 °C led to the enhancement of N‐(3‐amino‐4‐methylphenyl)benzamide production from about 42 to 76 % at a residence time of 420 s. It was found that the residence time and temperature have the largest influence on N‐(3‐amino‐4‐methylphenyl)benzamide production. Byproduct production was also increased by increasing the temperature and residence time.
Chiral Supramolecular Organogel Constructed Using Riboflavin and Melamine: Its Application in Photo‐Catalyzed Colorimetric Chiral Sensing and Enantioselective Adsorption
Authors: Oka Marina , Kozako Ryo , Teranishi Yuta , Yamada Yuta , Miyake Kazuhiro , Fujimura Takuya , Sasai Ryo , Ikeue Takahisa , Iida Hiroki 
Published: November 2023

AbstractThe synthesis of a chiral supramolecular organogel via the hierarchical helical self‐assembly of optically active riboflavin and melamine derivatives is described herein. Owing to the photocatalysis of riboflavin and the supramolecular chirality induced in the helically stacked riboflavin/melamine complex, the gel is observed to act as a light‐stimulated chiral sensor of optically active alcohols by detecting the change in color from yellow to green. The gel also served as an efficient chiral adsorbent, enabling optical resolution of a racemic compound with high chiral recognition ability.
Biological Evaluation of Isosteric Applicability of 1,3‐Substituted Cuneanes as m‐Substituted Benzenes Enabled by Selective Isomerization of 1,4‐Substituted Cubanes
Authors: Fujiwara Kan , Nagasawa Shota , Maeyama Ryusei , Segawa Ryosuke , Hirasawa Noriyasu , Hirokawa Takatsugu , Iwabuchi Yoshiharu 
Published: November 2023

AbstractWe herein evaluate a biological applicability of 1,3‐substituted cuneanes as an isostere of m‐substituted benzenes based on its structural similarity. An investigation of a method to obtain 1,3‐substituted cuneanes by selective isomerization of 1,4‐substituted cubanes enables this attempt by giving a key synthetic step to obtain a cuneane analogs of pharmaceuticals having m‐substituted benzene moiety. Biological evaluation of the synthesized analogs and in silico study of the obtained result revealed a potential usage of cuneane skeleton in medicinal chemistry.
Anatomy of the auditory cortex then and now
Authors: Rauschecker Josef P. , Afsahi Rosstin K. 
Published: November 2023

AbstractUsing neuroanatomical investigations in the macaque, Deepak Pandya and his colleagues have established the framework for auditory cortex organization, with subdivisions into core and belt areas. This has aided subsequent neurophysiological and imaging studies in monkeys and humans, and a nomenclature building on Pandya's work has also been adopted by the Human Connectome Project. The foundational work by Pandya and his colleagues is highlighted here in the context of subsequent and ongoing studies on the functional anatomy and physiology of auditory cortex in primates, including humans, and their relevance for understanding cognitive aspects of speech and language.