bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analgesic and Hemodynamic Effects of a Single 7.5‐mg Intravenous Dose of Morphine in Patients with Moderate‐to‐Severe Postoperative Pain
Authors: Larijani Ghassem E. , Goldberg Michael E. , Gratz Irwin , Warshal David P. 
Published: November 2004

Study Objectives. To evaluate the analgesic and hemodynamic effects of a single dose of intravenous morphine 7.5 mg in patients experiencing moderate‐to‐severe postoperative pain, and to determine any gender differences in analgesic response.Design. Randomized, double‐blind, parallel‐group, multicenter study.Setting. Postanesthesia care unit of a university teaching hospital.Patients. Eighty‐eight patients who underwent total abdominal hysterectomy or prostatectomy.Intervention. Thirty‐seven patients received a single dose of morphine sulfate 7.5 mg and 51 patients received placebo, both administered intravenously for 1 minute.Measurements and Main Results. Overall, morphine had no significant effect on systolic or diastolic blood pressure, heart rate, oxygen saturation, or respiratory rate. Compared with baseline, morphine significantly reduced pain intensity at 2, 5, and 10 minutes after administration (p<0.05). The difference in pain intensity between patients who received morphine and those who received placebo, however, was significant only at the 5‐minute time point (p<0.02). Patients receiving morphine also reported mild pain relief at 2 and 5 minutes after its administration. Peak analgesic effect was reported 2 minutes after its administration in three quarters of the patients. Significant gender differences also were observed in response to analgesic effect. In women, no significant differences in pain intensity were seen at any time between the morphine and placebo groups, whereas in men receiving morphine, pain intensity was significantly less at 2, 5, and 10 minutes compared with baseline and that seen in the placebo group. Women were generally more satisfied with their pain treatment than were men.Conclusion. A single 7.5‐mg intravenous bolus dose of morphine did not appear to provide adequate reduction in perceived pain intensity in patients with moderate‐to‐severe postoperative pain. In addition, in contrast to the findings of other experimental pain studies, our data suggest that women are more tolerant of postoperative pain than are men.
A Novel Spectrophotometric Determination of Some Phenothiazines Involving Iodine monochloride from Chloramine‐T with Iodine
Authors: Gowtham Malledevarapura D. , Kumar Mysore S. Yogendra , Sathish Mahadeshwarabetta A. , Nagendrappa Giddappa 
Published: November 2004

AbstractA novel, simple, sensitive spectrophotometric method is proposed for the determination of five phenothiazines. Chloramine‐T with iodine in acetic acid produces iodine monochloride which oxidizes phenothiazines to absorbing cations. Those would associate later with unreacted ICl to form an ion pair, [Ph+] [ICl–2] in hydrochloric acid medium. These appear to provide exceptional color stability to the systems. A probable mechanism along with experimental stoichiometry and stability constants of such ion pairs is indicated. The method is not only successful in stabilizing the color of the systems, but also in making a unique observation of two regions of concentration of phenothiazines adhering separately to Beer's law. The results obtained from the analyses of pure samples and their drug formulations in both regions of concentration are comparable with those obtained either with a reported titrimetric method or with a British Pharmacopoeia (B.P.) UV‐spectrophotometric method. The conditions required for the quantitative determination of phenothiazines are described and related analytical parameters are also calculated.
Synthesis, Structure, and Cytostatic Properties of New Olivacine Derivatives
Authors: Jasztold‐Howorko Ryszard , Croisy Alain , Carrez Daniele , Jaroszewicz Iwona , Nasulewicz Anna , Pełczyńska Marzena , Opolski Adam 
Published: November 2004

AbstractStarting from 2‐(6‐methoxy‐1‐methyl‐9H‐carbazol‐2‐yl)ethylamine and 6‐methylpicolinic acid, 9‐methoxy‐5‐methyl‐1‐(6‐methylpyridin‐2‐yl)‐6H‐pyrido[4, 3‐b]carbazole 10 and its 6‐alkylderivatives 12 – 17 were obtained. The newly obtained compounds showed significant cytostatic activity against cultured L1210 cells and high cytotoxicity towards various human tumor cell lines.
Dual Behavior of Masked o‐Benzoquinones in Intramolecular Diels—Alder Reactions with Acyclic Dienes: A Rapid Entry to Polyfunctionalized Bicyclo[2.2.2]oct‐5‐en‐2‐ones and cis‐Decalins.
Authors: Chen Chien‐Hsing , Peddinti Rama Krishna , Rao N. S. Kameswara , Liao Chun‐Chen 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Optimization and Metabolic Stabilization of a Class of Nonsteroidal Glucocorticoid Modulators.
Authors: Link J. T. , Sorensen Bryan K. , Patel Jyoti , Arendsen David , Li Gaoquan , Swanson Susan , Nguyen Bach , Emery Maurice , Grynfarb Marlena , Goos‐Nilsson Annika 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stereoselective Synthesis of 3‐Alkylideneoxindoles Using Tandem In‐Mediated Carbometalation and Pd‐Catalyzed Cross‐Coupling Reaction.
Authors: Yanada Reiko , Obika Shingo , Oyama Munetaka , Takemoto Yoshiji 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Application of Multi‐Component Reactions to Antimalarial Drug Discovery. Part 1. Parallel Synthesis and Antiplasmodial Activity of New 4‐Aminoquinoline Ugi Adducts.
Authors: Musonda Chitalu C. , Taylor Dale , Lehman Julie , Gut Jiri , Rosenthal Philip J. , Chibale Kelly 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cover Picture: Synthesis of a Fluorescent Sulfatide for the Study of CD1 Antigen Binding Properties (Eur. J. Org. Chem. 23/2004)
Authors: Franchini Laura , Compostella Federica , Donda Alena , Mori Lucia , Colombo Diego , De Libero Gennaro , Matto Pamela , Ronchetti Fiamma , Panza Luigi 
Published: November 2004

AbstractThe cover picture shows a model of a fluorescent derivative of sulfatide superimposed on the antigen‐presenting molecule CD1a (PDB accession code 1ONQ). In spite of the presence of the fluorescent probe, this derivative maintains its ability to bind to CD1a immobilized on beads and opens the possibility of performing binding studies by flow cytometry. Details of the synthesis of this fluorogenic sulfatide are reported in the article by F. Compostella, L. Panza et al. on p. 4755 ff.
Inhibition of Ru Complex Electrochemiluminescence by Phenols and Anilines
Authors: Cui Hua , Li Feng , Shi Ming‐Juan , Pang Yong‐Qiang , Lin Xiang‐Qin 
Published: November 2004

AbstractThe effect of 30 phenols and anilines on typical Ru complex electrochemiluminescence (ECL) was systematically investigated under different conditions. It was found that all the tested compounds showed an ECL inhibiting signal. The magnitude of ECL inhibition was related to the position of the substituting group in the benzene ring and decreased in the following order: meta‐>ortho‐>para‐. The oxidation potential of the tested compounds, the ECL spectra and UV‐visible absorption spectra of Ru(bpy)$\rm{ {_{3}^{2+}}}$/tripropylamine (TPrA) in the presence of phenols and anilines, and the direct ECL between Ru(bpy)$\rm{ {_{3}^{2+}}}$ and phenols/aniline were studied. The mechanism of ECL inhibition has been proposed due to energy transfer from the excited state Ru(bpy)$\rm{ {_{3}^{2+}}}$$\rm{{^\cdot}}$ to a quinone or ketone or their polymer formed by electro‐oxidation of phenols and anilines. The potential of analytical application was explored by use of the inhibited ECL. The results demonstrate that numerous compounds are detectable with the detection limits in the range of 10−8–10−9 mol/L for Ru(bpy)$\rm{ {_{3}^{2+}}}$/TPrA system and in the range of 10−6–10−7 mol/L for Ru(bpy)$\rm{ {_{3}^{2+}}}$/C2O$\rm{ {_{4}^{2}}}$ system, respectively.
Bias correction of daily precipitation measurements for Mongolia
Authors: Zhang Yinsheng , Ohata T. , Yang Daqing , Davaa G. 
Published: November 2004

AbstractBias correction procedures derived from the World Meteorological Organization's solid precipitation measurement intercomparison dataset for the Tretyakov rain gauge were applied to 20 years of data from 31 meteorological stations in Mongolia. Daily corrections of precipitation biases from wind‐induced undercatch, wetting loss, and evaporation loss were made. The bias (systematic error) from wind loss dominates at stations located in prairies and forests. Evaporation loss (caused by the evaporation of precipitation in the gauge before precipitation is measured) and wetting loss of precipitation both cause significant error in regions of low precipitation. Bias corrections suggest that gauge‐measured annual precipitation was significantly underreported by 15·2 to 80·6 mm over the 20 years studied. Annual precipitation in Mongolia should be 17 to 42% higher than previously reported, particularly in forests and prairies. The correction factor (CF, corrected/gauge‐measured precipitation) varies seasonally and is greater in winter and smaller in summer, primarily because of undercatch of snowfall due to winds. There is clear seasonal variation in the absolute value of the bias correction and in each individual component of the correction. The spatial variation in the absolute correction matches the spatial distribution of gauge‐measured precipitation. The value of CF decreases as gauge‐measured annual precipitation increases, because precipitation changes occurred mostly in summer. These results will be useful for hydrologic and climatic studies of mid‐latitudes and arid/semi‐arid regions. Copyright © 2004 John Wiley & Sons, Ltd.
Hydrological regions in monsoon Asia
Authors: Kondoh Akihiko , Harto Agung Budi , Eleonora Runtunuwu , Kojiri Toshiharu 
Published: November 2004

AbstractMonsoon Asia is characterized by its diversity of natural and social environments. These environments range from humid tropics to arid regions and there exist associated various hydrological phenomena. This paper attempts to characterize the hydrological regions of monsoon Asia based on the water budget calculated using grid‐based global datasets. A map of hydrological regions is created by ranking the value of water surplus and deficit. A humid zone with large water surplus extending from Southeast Asia to the Japanese archipelago, rapid transition from humid to arid environments in eastern China, and an arid region surrounded by a humid region in continental Southeast Asia are the most remarkable features in monsoon Asia. The map reveals that an essential characteristic of monsoon Asia is the proximity of the arid and humid environments. Many water problems and water management practices in a region can be easily understood by plotting them on a map. The boundaries of several large river basins are superimposed on the map, and examined for the water budget and flow regimes. The results are found to explain the regional characteristics of the seasonal runoff regimes satisfactorily. The importance of using a spatial framework for the comparative hydrological study in Monsoon Asia is highlighted. Copyright © 2004 John Wiley & Sons, Ltd.
VP22‐mediated intercellular transport correlates with enhanced biological activity of MybEngrailed but not (HSV‐I) thymidine kinase fusion proteins in primary vascular cells following non‐viral transfection
Authors: Sheridan Paul J. , Lawrie Allan , Crossman David C. , Holt Cathy M. , Newman Christopher M. 
Published: November 2004

AbstractBackgroundThe intercellular transport properties of the herpes simplex virus (HSV) protein VP22 have been harnessed to enhance the effectiveness of viral gene transfer. We investigated the intercellular transport and biological effects of VP22 fused with the dominant negative c‐Myb chimera, MybEngrailed (MybEn) and HSV‐I thymidine kinase (TK), in primary vascular smooth muscle cells (VSMC) following non‐viral transfection.Materials and methodsPorcine VSMC transfected with plasmids encoding MybEn, TK and their respective N‐ and C‐terminal VP22 fusion proteins were assayed for the extent and distribution of transgene expression (by immunohistochemistry), culture growth and apoptosis.ResultsThe N‐terminal MybEn fusion with VP22 (MybEnVP22) and both TK fusions, but not VP22MybEn, exhibited intercellular spread from primary transfected to up to 200 surrounding cells. pMybEnVP22‐transfected cultures exhibited growth inhibition and apoptosis rates that were 10.6 ± 3.6 and 3.2 ± 1.0 fold higher than in pMybEn‐transfected cultures; pVP22MybEn‐transfected cultures showed no difference in these parameters. pTK‐transfected cultures underwent 60–70% cell death in the presence of ganciclovir despite <2% primary transfection, which was not increased in cultures transfected with plasmids encoding VP22‐TK fusions.ConclusionsThe close correlation between immunocytochemical and biological assays suggests that intercellular transport is crucial to the enhanced biological activity of the MybEnVP22 fusion. The ‘intrinsic’ bystander activity of TK was 4‐fold greater than was ‘engineered’ by VP22 fusion, probably reflecting the abundance of gap junctions between VSMC. VP22 fusion may enhance the efficiency of non‐viral gene delivery when combined with the appropriate therapeutic transgene, target tissue and transfection method. Copyright © 2004 John Wiley & Sons, Ltd.
Raman spectroscopy of highly aligned thin films of Sr2FeMoO6
Authors: Zhang T. , Branford W. R. , Trodahl H. J. , Sharma A. , Rager J. , MacManus‐Driscoll J. L. , Cohen L. F. 
Published: November 2004

AbstractWe report a comparative study of polarization‐resolved Raman spectra of highly aligned thin films of Sr1.9A0.1FeMoO6 (A = Sr, Ca, Ba) and undoped bulk polycrystalline Sr2FeMoO6 at room temperature. The films were fabricated by a non‐vacuum chemical deposition technique on LaAlO3 substrates. A site group analysis was performed to establish that there are five Ag and seven Bg modes, most of which have been identified, and six Eg modes, although the latter are not accessible in the c‐axis aligned films. One Bg mode shows clear evidence of an asymmetric lineshape, which is discussed in terms of an interaction between phonons and electronic excitations. Copyright © 2004 John Wiley & Sons, Ltd.
Viscosity and starch particle size effects on rehydration of freeze‐dried carrots
Authors: Marabi Alejandro , Saguy I Sam 
Published: November 2004

AbstractA Correction has been published for this article in Journal of the Science of Food and Agriculture 85(4): 707 (2005).Rehydration is a critical step in the utilization of dry food particulates. The effects of viscosity and average particle size of four starches, namely corn, rice, potato and pre‐gelatinized Ultra Sperse 2000 were assessed and compared with water as the control. Average starch particle size diameters determined with image analysis showed that only the native starches swelled after 5 min treatment in 85 °C water. Rehydration curves were modelled utilizing a normalized Weibull distribution. The derived Weibull β‐shape parameter indicated that water uptake followed both imbibition and Fickian diffusion. Both viscosity and starch particles size distribution influenced the rehydration kinetics and their effect could not be explained by a simple mechanism. Medium uptake during rehydration could be improved and customized by choosing the most appropriate thickening agent. Copyright © 2004 Society of Chemical Industry
Comparison of sampling efficiency and storage stability on different sorbents for determination of solvents in occupational air
Authors: Gjølstad Merete , Bergemalm‐Rynell Kerstin , Ljungkvist Göran , Thorud Syvert , Molander Paal 
Published: November 2004

AbstractThis study describes the sampling efficiency and storage stability of compounds typically present in occupational atmospheres on the sorbents Anasorb CSC, Anasorb 747, and Chromosorb 106. The selection of compounds included in the study contained aliphatic and aromatic hydrocarbons, alcohols, esters, glycol ethers, ketones, and halogenated compounds, thus representing a wide range of chemical and physical properties. The different sorbent tubes were simultaneously exposed to the selected compounds as three different mixtures of solvent vapours in air, and storage both at room temperature and at –22°C was investigated. The sorbent tubes were stored and analyzed at two different laboratories. The sampling efficiencies of all the investigated compounds were excellent on Anasorb CSC and Anasorb 747, while Chromosorb 106 did not give such good results for the most volatile compounds under study. The room temperature storage stability on Chromosorb 106, however, was good for all compounds, although formation of artefacts was observed during storage, a disadvantage that was substantially reduced by storage at –22°C. The room temperature storage stability on Anasorb CSC was good for all compounds except some of the ketones. The room temperature storage stability of these ketones, especially cyclohexanone and 2‐butanone, was much better on Anasorb 747, which still showed the same excellent storage stability for the remaining compounds. When stored in a freezer, the storage stability of all compounds, including the ketones, was very good on all sorbents. Among the sorbents under study, Anasorb 747 appears to be the most suitable allround sorbent for monitoring volatile compounds in occupational air, with satisfactory capabilities regarding both sampling efficiency and storage stability.
Preconcentration and determination of priority pollutant phenols in waters at trace levels using a polymeric solid‐phase extraction cartridge
Authors: Sirvent Gemma , Sánchez Juan M. , Salvadó Victòria 
Published: November 2004

AbstractA method to preconcentrate and analyse the EPA priority pollutant phenols from water samples is evaluated. Spe‐ed Advanta® cartridges, containing 100 mg of a polymeric matrix modified with polar groups, are used in the extraction and enrichment step. Several parameters are studied in order to find the best experimental conditions to perform a solid‐phase extraction process. Sample flow rate and pH appear as variables that could significantly affect the recoveries obtained. Water samples need a pH adjustment to values lower than 3 units and must be percolated through the cartridges with flow rates over 5 mL min–1. The highest recoveries and preconcentrations are obtained using acetonitrile as the elution solvent. Sample volumes from 100 mL to 1 L with concentrations ranging from 50 to 0.5 μg L–1 are analysed with quantitative recoveries and similar efficiencies being achieved. After establishing the best conditions, we applied the method to the analysis of spiked natural waters.
Fatigue of glass fiber reinforced injection molded plastics. II: Tensile versus flexural loading
Authors: Wyzgoski Michael G. , Krohn John A. , Novak Glen E. 
Published: November 2004

AbstractA previous paper reported fatigue data for several glass fiber reinforced thermoplastic materials by measuring their S‐N, stress versus number of cycles to fail, behavior. It was demonstrated that both fiber orientation and loading mode, tensile versus flexural, strongly influence the resultant S‐N data. The orientation effects are considered real, reflecting the local fiber orientation distributions in the samples, which are determined by geometry, processing and material variables. However, the higher fatigue lives observed in flexural loading are considered an artifact. Specifically for this class of materials, it is concluded that the use of linear elastic beam bending theory equations to calculate bending stresses are inappropriate. It is shown that a plasticity‐based correction factor makes the flexural S‐N data equivalent to the tensile results. In fact this correction applies equally well to monotonic loading, not just fatigue. Although it is concluded that tensile loading is preferred, some cases where flexural loading may be advantageous are indicated. Polym. Compos. 25:569–576, 2004. © 2004 Society of Plastics Engineers.
When is a hypo not a hypo? Hypoglycaemic symptoms at normal glucose levels in poorly controlled type 2 diabetes
Authors: Chowdhury TA , Escudier VJ 
Published: November 2004

AbstractHypoglycaemia is common in patients with diabetes. Symptomatic hypoglycaemia at normal glucose levels has been previously recognised, and can pose a major challenge to improving glycaemic control. We describe two cases of patients with type 2 diabetes, who suffered from frequent symptoms of hypoglycaemia at normal glucose levels, leading to over‐compensation with carbohydrate and poor glycaemic control. We describe how recognition of this phenomenon led to significant improvements in glycaemic control. Copyright © 2004 John Wiley & Sons, Ltd.
Hydrogen‐bond‐assisted stereocontrol in the radical polymerization of N‐isopropylacrylamide with primary alkyl phosphate: The effect of the chain length of the straight ester group
Authors: Hirano Tomohiro , Ishii Satoshi , Kitajima Hiroko , Seno Makiko , Sato Tsuneyuki 
Published: November 2004

AbstractThe radical polymerizations of N‐isopropylacrylamide (NIPAAm) were carried out in toluene at low temperatures in the presence of phosphoric acid esters such as trimethyl phosphate, triethyl phosphate (TEP), tri‐n‐propyl phosphate, and tri‐n‐butyl phosphate (TBP). Syndiotactically rich poly(NIPAAm)s were obtained from −60 to 0 °C, and TEP provided the highest syndiotacticity (racemo dyad = 65%) at −40 °C. On the other hand, lowering the temperature reversed the stereoselectivity of the propagation reaction so that isotactically rich poly(NIPAAm)s were obtained at −80 °C. In particular, TBP exhibited the most isotactic specificity (meso dyad = 57%). Job's plots for NIPAAm–TBP mixtures revealed that NIPAAm and TBP formed a 1:1 complex at 0 °C and a predominantly 1:2 complex at −80 °C through a hydrogen‐bonding interaction. Therefore, the stereospecificity of NIPAAm polymerization should depend on the stoichiometry of the hydrogen‐bond‐assisted complex. Thus, the mechanism for this polymerization system was discussed. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 50–62, 2005
Monitoring k‐step‐ahead Controlled Processes
Authors: Nugent Edward , Baykal‐Gürsoy Melike , Gürsoy Kemal 
Published: November 2004

AbstractA dynamical system controlled by a k‐step‐ahead minimum variance controller is considered. Independent, identically distributed one‐step‐ahead process residuals are given for use in statistical process monitoring schemes. Problems encountered in the application of the monitoring schemes are discussed, particularly with respect to detecting process upsets. Upsets may occur in any of three ways, for which expressions are derived. It is shown that the mechanism by which upsets occur influences the ability of the residuals to detect the upsets. It is also shown that the effect of the disturbance on the residuals is independent of the process time delay k. The ability of the residuals to detect a change in the process dispersion is discussed. It is shown that the disturbance dynamics do not alter this ability. This information is useful in obtaining accurate estimates of control chart performance and directing the statistical process control practitioner in modifying the control chart design. Copyright © 2004 John Wiley & Sons, Ltd.
Unrestricted Hartree–Fock then and now
Authors: Nesbet R. K. 
Published: November 2004

AbstractThe unrestricted Hartree–Fock model of interacting electrons originated as an approximation that incorporates exchange‐polarization effects for open‐shell atoms and molecules. Spontaneous symmetry‐breaking is described by this model, in particular for dissociating covalent bonds, but is limited to exchange in the Hartree–Fock context. When this model is extended to an orbital functional theory, which can include quantitative effects of electronic correlation, it becomes a widely applicable formalism for many‐body theory. This conceptual extension is discussed. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2005