bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gesture Recognition for Feedback Based Mixed Reality and Robotic Fabrication: A Case Study of the UnLog Tower
Authors: Htet Kyaw Alexander , Spencer Lawson , Zivkovic Sasa , Lok Leslie 
Published: January 2024

AbstractMixed Reality (MR) platforms enable users to interact with three-dimensional holographic instructions during the assembly and fabrication of highly custom and parametric architectural constructions without the necessity of two-dimensional drawings. Previous MR fabrication projects have primarily relied on digital menus and custom buttons as the interface for user interaction with the MR environment. Despite this approach being widely adopted, it is limited in its ability to allow for direct human interaction with physical objects to modify fabrication instructions within the MR environment. This research integrates user interactions with physical objects through real-time gesture recognition as input to modify, update or generate new digital information enabling reciprocal stimuli between the physical and the virtual environment. Consequently, the digital environment is generative of the user’s provided interaction with physical objects to allow seamless feedback in the fabrication process. This research investigates gesture recognition for feedback-based MR workflows for robotic fabrication, human assembly, and quality control in the construction of theUnLog Tower.
A ‘Human-In-The-Loop’ Workflow for Realizing Taihu Rocks
Authors: Chen Zexin , Lin Dandan , Sun Lujie , Wang Sining , Han Dongchen 
Published: January 2024

AbstractThis research uses an expanded polystyrene (EPS) Taihu rock as a demonstrator to illustrate a workflow encompassing shape grammar-based design and Mixed Reality (MR)-aided robotic fabrication. It aims to address a post-digital mindset that values human’s tacit knowledge and craftsmanship within CAD-CAM processes, therefore, this research combines three components: an idea of the human-cyber-physical system (HCPS), a from-finding approach, and an augmented materialization method. The investigators first 3D-scanned a natural Taihu rock and interpreted its geometric peculiarities into design generation rules. These rules were then translated into robotic foam-cutting paths. With Head-mounted Display (HMD) and MR technology, human fabricators were able to alter robotic motions on-site per their aesthetical demands.
DeepCraft: Co-Intelligent Architecture and Human and AI-Driven Craftsmanship in Design-to-Production Pipelines
Authors: Buš Peter 
Published: January 2024

AbstractThe working paper investigates the potential of artificial intelligence technologies (AI), namely the Generative Adversarial Imitation Learning (GAIL) implemented in a process of digital robotic fabrication prospectively to be used in craftsmanship. The method introduced is based on a preliminary demonstration provided digitally in an abstract toolpath generated by a human-driven movement in a hand gesture translated into a digital space in a real-time process. The investigation presented in this paper focuses on a preliminary computational digital framework which may serve as a base for further investigation. At this stage of the report, the framework encompasses human hand recognition creating a toolpath for a robot, which learns its principles and tries to interpret the process in a digital space. This learned toolpath resulted in a digital brain being applied again in a different shape of the human-created toolpath or gesture movement. The paper also presents the computational system of the real-time navigation of the robot based on a human gesture in a virtual space. The learned knowledge by a robot is observed in a digital environment before any physical applications.
Membrane-Based Modularization in Prefabrication System Design as a Strategy in Emergency Buildings
Authors: Su Yunsheng , Cheng Xihan , Li Jiaxing 
Published: January 2024

AbstractThis article is about the application of air film-based modular prefabrication system design strategy in emergency buildings. To determine the typical and essential behavior of membrane structures, this paper reviews and compares relevant theories, experiments, and simulations on architectural performance, mechanical properties of membrane materials, and membrane structure performance. In addition, this project tries to use the robotic arm spraying technology to study the strategy of trajectory generation. First, import the model shape into the software for multiple trajectory simulations, verify and optimize the injection path program through the software, observe the actual injection trajectory, and finally select the final Program. The resulting vectors are also relatively balanced, avoiding the over-concentration of the top curve. The advantage of this method is that it can reduce the material on the top and make the material distribution more uniform, which is a more economical and reasonable way to obtain the trajectory.
Translucent Tectonics: Lightweight Floor Slab System Based on FDM Manufacturing
Authors: Liu Yizhuo , Hua Hao 
Published: January 2024

AbstractA construction method for an FDM printed floor slab system is proposed in this paper. The integration of translucent thermoplastics and additive manufacturing enables architects to develop self-explanatory tectonics that reflect the logic and construction processes. Lightweight, transparent thermoplastics such as PET and PLA can be used in 3D printing to create visual contrast to conventional solid materials. The additive manufacturing process can improve structural behavior by controlling the material distribution. Therefore, the proposed floor slab system pursues ‘light and strong’ via using a carefully planned toolpath for FDM printing. An entire floor is subdivided into prefabricated modular components, which are then assembled using the post-tensioning method to improve the integrity and tensile strength of the floor system. A toolpath is designed based on the internal stress of the components such that the material density reflects the structural behavior of the floor slab. The material efficiency is thereby achieved by the optimized articulation. In addition, we maximize the continuity of the printing path to enhance the printing quality and reduce the manufacturing time. This construction method is applied to the renovation of a group of industrial buildings. Prototyping experiments were carried out using translucent PLA to visualize the material distribution inside modules, manifesting the design principle of “form follows performance”.
Feedback-Based Design Method for Spatially-Informed and Structurally-Performative Column Placement in Multi-Story Construction
Authors: Sahin Ekin Sila , Locatelli Daniel , Orozco Luis , Krtschil Anna , Wagner Hans Jakob , Menges Achim , Knippers Jan 
Published: January 2024

AbstractThis paper presents a feedback-based computational method for the placement of columns in the early design phase of complex multi-story structures. The method integrates a circle packing algorithm, a spring system, and structural engineering simulations within a single script for the reciprocal and informed arrangement of columns in the space. While allowing the users to have an explorative approach, it empowers diverse potentials in multi-story constructions including additional cantilevering spaces around the boundary, increased spatial qualities with large span possibilities, multidirectional structural arrangements, and multi-purpose use of space. As a result, the developed algorithm allows for flexibility by leveraging the design possibilities of grid-based and irregular column arrangements and promotes the integration of structural and design-related constraints in the spatial organization of various building typologies.
Cardiac risk stratification and adverse outcomes in surgically managed patients with isolated traumatic spine injuries
Authors: Mohammad Ismail Ahmad , Forssten Maximilian Peter , Hildebrand Frank , Sarani Babak , Ioannidis Ioannis , Cao Yang , Ribeiro Marcelo A. F. , Mohseni Shahin 
Published: January 2024

Abstract
Introduction
As the incidence of traumatic spine injuries has been steadily increasing, especially in the elderly, the ability to categorize patients based on their underlying risk for the adverse outcomes could be of great value in clinical decision making. This study aimed to investigate the association between the Revised Cardiac Risk Index (RCRI) and adverse outcomes in patients who have undergone surgery for traumatic spine injuries.

Methods
All adult patients (18 years or older) in the 2013–2019 TQIP database with isolated spine injuries resulting from blunt force trauma, who underwent spinal surgery, were eligible for inclusion in the study. The association between the RCRI and in-hospital mortality, cardiopulmonary complications, and failure-to-rescue (FTR) was determined using Poisson regression models with robust standard errors to adjust for potential confounding.

Results
A total of 39,391 patients were included for further analysis. In the regression model, an RCRI ≥ 3 was associated with a threefold risk of in-hospital mortality [adjusted IRR (95% CI): 3.19 (2.30–4.43), p < 0.001] and cardiopulmonary complications [adjusted IRR (95% CI): 3.27 (2.46–4.34), p < 0.001], as well as a fourfold risk of FTR [adjusted IRR (95% CI): 4.27 (2.59–7.02), p < 0.001], compared to RCRI 0. The risk of all adverse outcomes increased stepwise along with each RCRI score.

Conclusion
The RCRI may be a useful tool for identifying patients with traumatic spine injuries who are at an increased risk of in-hospital mortality, cardiopulmonary complications, and failure-to-rescue after surgery.
Potential factors contributing to observed sex differences in virtual-reality-induced sickness
Authors: Bannigan Grainne M. , de Sousa Alexandra A. , Scheller Meike , Finnegan Daniel J. , Proulx Michael J. 
Published: January 2024

AbstractVirtual reality (VR) technology has been widely adopted for several professional and recreational applications. Despite rapid innovation in hardware and software, one of the long prevailing issues for end users of VR is the experience of VR sickness. Females experience stronger VR sickness compared to males, and previous research has linked susceptibility to VR sickness to the menstrual cycle (Munafo et al., Exp Brain Res 235(3):889–901). Here we investigated the female versus male experience in VR sickness while playing an immersive VR game, comparing days of the menstrual cycle when hormones peak: day 15 (ovulation—peak estrogen) and day 22 (mid-luteal phase—peak progesterone). We found that immersion duration was greater in the second session than the first, and discomfort was lessened, suggesting a powerful adaptation with repeated exposure. Due to the estrogen levels changing along with the exposure, there was no clear independent impact of that; note, though, that there was a significant difference between self-report and physiological measures implying that GSR is potentially an unreliable measure of motion sickness. Although prior work found a delay over 2 days between session would not allow adaptation and habituation to reduce VR sickness susceptibility, we found that a week delay has potential success.
Infective endocarditis after isolated aortic valve replacement: comparison between catheter-interventional and surgical valve replacement
Authors: Ried Isabelle D. , Omran Hazem , Potratz Max , Rudolph Tanja K. , Scholtz Smita , Bleiziffer Sabine , Piper Cornelia 
Published: January 2024

Abstract
Background and aims
Prosthetic valve endocarditis (PVE) is the prognostically most unfavourable complication after aortic valve replacement. This study aims to contribute to a better understanding of the different pathological and therapeutical aspects between PVE following surgical (SAVR) and transcatheter aortic valve replacement (TAVI).

Methods
All patients who had undergone primary isolated SAVR (n = 3447) or TAVI (n = 2269) at our Centre between 01/2012 and 12/2018 were analysed. Diagnosis of PVE was based on Duke criteria modified in 2015. Incidence, risk factors, pathogens, impact of complications or therapy on mortality were analysed and compared between SAVR- and TAVI-PVE.

Results
PVE incidence did not differ significantly after SAVR with 4.9/100 patient-years and TAVI with 2.4/100 patient-years (p = 0.49), although TAVI patients were older (mean 80 vs. 67 years) and had more comorbidities (STS score mean 5.9 vs. 1.6) (p < 0.001). TAVI prostheses with polymer showed a 4.3-fold higher risk to develop PVE than without polymer (HR 4.3; p = 0.004). Most common pathogens were staphylococci and enterococci (p > 0.05). Propensity-score matching analysis showed that the type of aortic valve replacement had no effect on the development of post-procedural PVE (p = 0.997). One-year survival was higher in TAVI-PVE patients treated with antibiotics only compared to additional surgical therapy (90.9% vs. 33.3%; p = 0.005). In SAVR-PVE patients, both therapies were comparable in terms of survival (p = 0.861). However, SAVR-PVE patients who were not operated, despite ESC-guideline recommendation, had significantly poorer one-year survival (p = 0.004).

Conclusion
TAVI patients did not have a significantly higher risk to develop PVE. Our data suggest that TAVI-PVE patients in contrast to SAVR-PVE patients can more often be treated with antibiotics only, presumably due to the lack of a polymeric suture ring.

Graphical abstract
Key question:

What are the differences between SAVR- and TAVI-PVE?

Are the current ESC guidelines for the treatment of SAVR-PVE also applicable to TAVI-PVE?

Key finding:

No significantly different PVE incidences after SAVR and TAVI

Significantly better one-year survival and significantly longer survival in TAVI-PVE treated with antibiotics only compared with additional surgical therapy

Higher risk to develop PVE after TAVI in patients carrying prostheses containing polymer particles

Take-home message

TAVI-PVE can often be treated successfully with antibiotics-only, even if surgery would have been indicated according to current guidelines.

SAVR-PVE patients benefit from surgical therapy, so guideline-compliant surgical indication should be made promptly and performed immediately
Accessibility of osteochondral lesion at the capitellum during elbow arthroscopy: an anatomical study
Authors: Wegmann S. , Hackl M. , Krane F. , Wegmann K. , Mueller L.-P. , Leschinger T. 
Published: January 2024

Abstract
Introduction
Osteochondrosis dissecans (OCD) at the capitellum is a common pathology in young patients. Although arthroscopic interventions are commonly used, there is a lack of information about the accessibility of the defects during elbow arthroscopy by using standard portals.

Materials and methods
An elbow arthroscopy using the standard portals was performed in seven fresh frozen specimens. At the capitellum, the most posterior and anterior cartilage surface reachable was marked with K-wires. Using a newly described measuring method, we constructed a circular sector around the rotational center of the capitellum. The intersection of K-wire “A” and “B” with the circular sector was marked, and the angles between the K-wires and the Rogers line, alpha angle for K-Wire “A” and beta angle for K-wire “B”, and the corridor not accessible during arthroscopy was digitally measured.

Results
On average, we found an alpha angle of 53° and a beta angle of 104°. Leaving a sector of 51° which was not accessible via the standard portals during elbow arthroscopy.

Conclusion
Non-accessible capitellar lesions during elbow arthroscopy should be considered preoperatively, and the informed consent discussion should always include the possibility of open procedures or the use of flexible instruments.

Level of Evidence
4.
Topical sodium valproate-loaded nanospanlastics versus conventional topical steroid therapy in alopecia areata: a randomized controlled study
Authors: Mogawer Rania M. , Fawzy Marwa Mohamed , Mourad Ahmed , Ahmed Heba , Nasr Maha , Nour Zeinab Ahmed , Hafez Vanessa 
Published: January 2024

Abstract
Background
A myriad of therapeutic modalities for alopecia areata are available; however, none is of high level of evidence, creating an immense need for the evaluation of other treatment modalities, of which topical sodium valproate is of potential role via proposed decrease in beta-catenin breakdown, despite its well-known side effect of hair fall as an oral therapy.

Objective
Evaluating the efficacy and the safety of sodium valproate (SV)-loaded nanospanlastics, in comparison to topical corticosteroids, this is the currently available gold standard topical treatment for patchy AA.

Methodology
A total of 66 patients with patchy AA were randomly assigned to receive either topical mometasone furoate lotion or topical SV applied twice daily to all patches except a control patch, which was left untreated. Clinical, trichoscopic and biochemical assessments of beta-catenin tissue levels and Axin-2 gene expression were carried out at baseline and after 3 months.

Results
Both therapeutic modalities were comparable. Potential efficacy was highlighted by significant improvement in the representative patch, the largest treated patch, to the control patch, the smallest untreated patch in both steroid and valproate groups (p = 0.027, 0.003 respectively). Both beta-catenin levels and Axin-2 gene expression were reduced after treatment, pointing to the inhibitory effect of dominating uncontrolled inflammatory milieu. Baseline beta-catenin was found to significantly negatively correlate with improvement in the representative patch in patients with baseline level above 0.42 ng/ml (p = − 0.042).

Conclusion
Both topical SV and steroids are of comparable modest efficacy. Thus, further evaluation of SV is due in combination with intralesional steroids and other anti-inflammatory treatment modalities, together with developing individualized approaches based on baseline beta-catenin level.

ClinicalTrials.gov Identifier
NCT05017454, https://clinicaltrials.gov/ct2/show/NCT05017454.
Characterization of two transcriptomic subtypes of marker-null large cell carcinoma of the lung suggests different origin and potential new therapeutic perspectives
Authors: Simbolo Michele , Centonze Giovanni , Gkountakos Anastasios , Monti Valentina , Maisonneuve Patrick , Golovco Stela , Sabella Giovanna , Del Gobbo Alessandro , Gobbo Stefano , Ferrero Stefano , Fabbri Alessandra , Pardo Carlotta , Garzone Giovanna , Prinzi Natalie , Pusceddu Sara , Testi Adele , Rolli Luigi , Mangogna Alessandro , Bercich Luisa , Benvenuti Mauro Roberto , Bria Emilio , Pilotto Sara , Berruti Alfredo , Pastorino Ugo , Capella Carlo , Infante Maurizio , Milella Michele , Scarpa Aldo , Milione Massimo 
Published: January 2024

AbstractPulmonary large cell carcinoma (LCC) is an undifferentiated neoplasm lacking morphological, histochemical, and immunohistochemical features of small cell lung cancer, adenocarcinoma (ADC), or squamous cell carcinoma (SCC). The available molecular information on this rare disease is limited. This study aimed to provide an integrated molecular overview of 16 cases evaluating the mutational asset of 409 genes and the transcriptomic profiles of 20,815 genes. Our data showed that TP53 was the most frequently inactivated gene (15/16; 93.7%) followed by RB1 (5/16; 31.3%) and KEAP1 (4/16; 25%), while CRKL and MYB genes were each amplified in 4/16 (25%) cases and MYC in 3/16 (18.8%) cases; transcriptomic analysis identified two molecular subtypes including a Pure-LCC and an adenocarcinoma like-LCC (ADLike-LCC) characterized by different activated pathways and cell of origin. In the Pure-LCC group, POU2F3 and FOXI1 were distinctive overexpressed markers. A tuft cell-like profile and the enrichment of a replication stress signature, particularly involving ATR, was related to this profile. Differently, the ADLike-LCC were characterized by an alveolar-cell transcriptomic profile and association with AIM2 inflammasome complex signature. In conclusion, our study split the histological marker-null LCC into two different transcriptomic entities, with POU2F3, FOXI1, and AIM2 genes as differential expression markers that might be probed by immunohistochemistry for the differential diagnosis between Pure-LCC and ADLike-LCC. Finally, the identification of several signatures linked to replication stress in Pure-LCC and inflammasome complex in ADLike-LCC could be useful for designing new potential therapeutic approaches for these subtypes.
Wet anaerobic digestion of organic fraction of municipal solid waste: experience with long-term pilot plant operation and industrial scale-up
Authors: Anaya-Reza Omar , Altamirano-Corona María F. , Basurto-García Germán , Patricio-Fabián Héctor , García-González Sergio A. , Martinez-Hernandez Elias , Durán-Moreno Alfonso 
Published: January 2024

AbstractThis paper presents the analysis of a pilot anaerobic digestion plant that operates with organic fraction of municipal solid waste (OFMSW) from a wholesale market and can treat up to 500 kg d−1. The process was monitored for a period of 524 days during which the residue was characterized and the biogas production and methane content were recorded. The organic load rate (OLR) of volatile solids (VS) was 0.89 kg m−3 d−1 and the Hydraulic Retention Time (HRT) was 25 d during the process. The yield was 82 Nm3 tons OFMSW−1 biogas, equivalent to 586 Nm3 tons CH4 VS−1. The results obtained in the pilot plant were used to carry out a technical–economic evaluation of a plant that treats 50 tons of OFMSW from wholesale markets. A production of 3769 Nm3 d−1 of biogas and 2080 Nm3 d−1 of methane is estimated, generating 35.1 MWh d−1 when converted to electricity.
A 6-year review of acute post-streptococcal glomerulonephritis at a public children’s hospital in Cape Town, South Africa
Authors: Abugrain Khadija , McCulloch Mignon I , Muloiwa Rudzani , Luyckx Valerie A , Buys Heloise 
Published: January 2024

Abstract
Background
Acute post-streptococcal glomerulonephritis (APSGN) is the most common cause of acute nephritis in children globally and, in some cases, may be associated with progressive kidney injury and failure, cumulating in the need for long-term dialysis and/or kidney transplantation.

Methods
Our retrospective study describes the occurrence of APSGN among children (< 14 years) admitted to a tertiary children’s hospital in Cape Town, South Africa, from January 2015 to December 2020.

Results
Of 161 children who presented with acute nephritis (haematuria, oedema, oliguria, and hypertension), 100 met the inclusion criteria. Demographic, clinical features, laboratory findings, management, and outcome data were collected. APSGN was defined by the clinical presentation of at least two clinical signs of acute nephritis, and low serum complement 3 (C3) level or evidence of a recent streptococcal infection. Most cases of APSGN were associated with streptococcal skin infections: 55/100 (55%); 10/100 (10%) children presented with hypertensive seizures; C3 levels were low in 86/92 (93.5%) children; 94/94 (100%) children had elevated anti-deoxyribonuclease-B (anti-DNase-B) levels; and 80/94 (85%) also had elevated anti-streptolysin O titre (ASOT) at presentation. Eleven (11%) children had a percutaneous kidney biopsy; 4/11 (36%) showed histological features of post-infectious nephritis, and 7/11(64%) also had crescentic glomerulonephritis with immune complex deposits. Sixty-two (62%) children confirmed recovered, and five (5%) progressed to kidney failure, but 29 presumed recovered as they did not return for follow-up to our institution.

Conclusions
Childhood APSGN remains an important health problem in South Africa (SA) with favourable outcomes in most, apart from those with crescentic glomerulonephritis who progressed to kidney failure.

Graphical abstract