bluuebunny/crossref_metadata_2025_split huggingface dataset:
Houses for People and Houses for Goats
Authors: Nyima Yonten , Yeh Emily T. 
Published: November 2023

Abstract
Since 2000, a number of programmes have been implemented in the Tibet Autonomous Region of China aimed at sedentarisation, defined as the spatial and temporal concentration of pastoralists and their livestock. In our case study village in Nagchu, a programme to move pastoralists into concentrated housing failed to sedentarise them. By contrast, a secondary programme component to build subsidised livestock shelters has had a much more pronounced effect on reducing human as well as livestock mobility. We adopt assemblage thinking as a methodology for critical policy analysis to understand how and why this was the case. Whereas no effort was made to undertake the labour needed to create an assemblage of herders living in concentrated housing, multiple contingent processes came together to create an assemblage around the reduction of mobility through the building of houses for goats. These include the biological effects of livestock shelters on goat tolerance to cold stress, as observed by herders, budget constraints in the goat shelter programme, as well as a long-standing village institution of unified livestock movement.
Further New Perspectives on Dostoevsky: ‘Winter Notes on Summer Impressions’. An Intermedial Approach to Dostoevsky’s London Visit
Authors: Zohrab Irene 
Published: November 2023

Abstract
The article examines F. M. Dostoevsky’s visit to London in the summer of 1862, in the course of his first trip abroad, which resulted in the writing of Winter Notes on Summer Impressions. A Summer-Long Feuilleton. The task to untangle the impact of numerous impressions on Dostoevsky’s creative process is initiated and the newly arisen circumstances that he encountered on his return to St. Petersburg highlighted. Winter Notes is viewed as a groundbreaking work in Dostoevsky’s canon that contains the seeds of future great works, though not primarily in accordance with the multiple ideologically based readings that have sought to define it. Instead Winter Notes is recognised for its author’s aesthetic explorations into poetics within the confines of Tsarist censorship which required that ‘Official Nationality’, the imperial ideological doctrine be upheld. Dostoevsky’s visit to the 1862 International Exhibition and its art galleries is addressed for the first time on the basis of his brother Mikhail’s letters and other evidence. The exhibition building and the works of William Hogarth, John Martin and J.M.W.Turner are singled out. Their imprint on Dostoevsky’s feuilleton is observed through the stages of impressions gained via intermedial interplay. It affirms that pre-existing notions in the ‘discourse of Englishness’ were absorbed and reinvented by Dostoevsky with the use of figurative language, clarifying the origin of metaphors used in the text, together with literary and biblical allusions. A list of Russian and British artists exhibiting in the International Exhibition of 1862 is included.
Victim Status of Individuals in Climate Change Litigation before the ECtHR
Authors: Mariconda Antonio 
Published: November 2023

Abstract
The climate change applications currently pending before the European Court of Human Rights (ECtHR) present substantial challenges to the status quo of the Strasbourg system, encompassing both merits and admissibility issues. Of particular concern is their compliance with the admissibility requirement outlined in Article 34 of the European Convention of Human Rights (echr), which stipulates that applicants must be victims of a violation of the Convention by a State to file a case before the Court. Given the diffuse nature of the harms stemming from climate change, identifying individuals as victims of its effects and, consequently, whose rights are allegedly infringed upon, becomes a complex task. Furthermore, establishing a direct causal link between the harm endured and the actions or omissions of a single State proves to be equally challenging. Therefore, the aim of this article is to scrutinize how this admissibility requirement might operate in the cases at hand. In particular, it argues that, albeit with some caveats, it is legally possible to consider some climate change applicants as both direct and potential victims, as per the definitions established by the case law of the ECtHR. Nevertheless, this solution could pose significant challenges to the legitimacy and efficiency of the Strasbourg system, which the Court will have to prevent when deciding these cases.
The effects of esketamine on the intestinal microenvironment and intestinal microbiota in mice
Authors: Zhang Ying , Ma Wenhao , Lin Hao , Gu Xuefeng , Xie Hong 
Published: November 2023

Objective This study aimed to investigate the impact of esketamine on the intestinal flora and microenvironment in mice using mRNA transcriptome sequencing and 16S rRNA sequencing. Methods Ten female mice were randomly assigned to two groups. One group received daily intramuscular injections of sterile water, while the other group received esketamine. After 24 days, the mice were sacrificed, and their intestinal tissues and contents were collected for 16S rRNA sequencing and mRNA transcriptome sequencing. The intergroup differences in the mouse intestinal flora were analyzed. Differentially expressed genes were utilized to construct ceRNA networks and transcription factor regulatory networks to assess the effects of esketamine on the intestinal flora and intestinal tissue genes. Results Esketamine significantly altered the abundance of intestinal microbiota, including Adlercreutzia equolifaciens and Akkermansia muciniphila. Differential expression analysis revealed 301 significantly upregulated genes and 106 significantly downregulated genes. The ceRNA regulatory network consisted of 6 lncRNAs, 44 miRNAs, and 113 mRNAs, while the regulatory factor network included 13 transcription factors and 53 target genes. Gene Ontology enrichment analysis indicated that the differentially expressed genes were primarily associated with immunity, including B-cell activation and humoral immune response mediation. The biological processes in the ceRNA regulatory network primarily involved transport, such as organic anion transport and monocarboxylic acid transport. The functional annotation of target genes in the TF network was mainly related to epithelial cells, including epithelial cell proliferation and regulation. Conclusion Esketamine induces changes in gut microbiota and the intestinal microenvironment, impacting the immune environment and transport modes.
Clinical management of feline chronic kidney disease in Portugal: a questionnaire-based study
Authors: Magalhães Tomás Rodrigues , Lourenço Ana Luísa , Corbee Ronald Jan , Queiroga Felisbina Luísa 
Published: November 2023

Objectives The aim of the study was to characterise the clinical management of feline chronic kidney disease (CKD) by veterinary practitioners in Portugal. Methods A questionnaire-based study was designed to be completed by all veterinarians who had diagnosed and treated at least one case of feline CKD in the previous year. Results A total of 409 veterinary practitioners responded to the questionnaire, with approximately half of them diagnosing 2–5 cases of feline CKD per month (n = 219, 53.5%). Although a high proportion of these reported using the guidelines published by the International Renal Interest Society (n = 379, 92.7%), only 19.1% (n = 78) systematically performed systolic blood pressure (SBP) measurements in all of their patients. A renal diet was advised by almost all respondents (n = 406, 99.3%), but 36.9% (n = 150) of them considered that it represented less than 75% of the daily food intake for most of their patients. This dietary intervention was often prescribed regardless of stage (n = 298, 73.4%) and without a proper gradual diet transition. Appetite stimulants were frequently prescribed (n = 366, 89.5%), as well as a calcium channel blocker (n = 171, 41.8%) and an angiotensin-converting enzyme inhibitor (n = 245, 59.9%) to control systemic hypertension and proteinuria, respectively. Prescription of a phosphate binder was also common (n = 311, 76.0%). Regarding monitoring, 70.9% (n = 290) recommended that stable patients be reassessed every 2–3 months or more frequently, but only 35.7% (n = 146) were able to comply with this periodicity due to owners’ constraints. Conclusions and relevance The findings showed that although most survey respondents are aware of international guidelines for the clinical management of cats with CKD, the SBP measurement still needs to be more systematic to allow proper substaging and detection of systemic hypertension. The monitoring frequency was lower than recommended. Furthermore, the introduction of a renal therapeutic diet should be refined to improve its acceptance rate.
Perimenopausal women’s voices: How does their period at the end of reproductive life affect wellbeing?
Authors: Ray Elizabeth , Maybin Jacqueline A , Harper Joyce C 
Published: November 2023

Objective To explore perimenopausal women’s feelings towards their periods, the impact on their wellbeing and how we can support them. Study design Participants were recruited for focus groups through social media advertisements. In 6 online focus groups, 31 perimenopausal women aged 40–55 living in the UK were asked 5 questions relating to periods and perimenopause, support and education. Main outcome measures Content analysis. Results When asked How do you feel about having a period? The participants often related back to the stress of menarche and said their period negatively impacted their wellbeing their whole lives. During perimenopause, their periods had become unpredictable, heavy, and a debilitating disruption to their lives. The women desired support at work through policy, and from family and friends. They believed that educating girls and boys during school was the best place to start, but that education through work and community groups was also needed. They felt healthcare professionals should have mandatory training regarding women’s health issues and menopause. Conclusion The study highlights the impact of menstrual experiences on the wellbeing of perimenopausal women, emphasising the need for improved menstrual education from an early age. Comprehensive menstrual education in schools involving both genders to enable informed decision-making and improved training for healthcare professionals are recommended. Support networks for perimenopausal women will promote better quality of life for women as they go through their perimenopause journey.
Analysis of Personalized Interbody Implants in the Surgical Treatment of Adult Spinal Deformity
Authors: Smith Justin S. , Mundis Gregory M. , Osorio Joseph A. , Nicolau Rodrigo J. , Temple-Wong Michele , Lafage Renaud , Bess Shay , Ames Christopher P. 
Published: November 2023

Study Design Multicenter cohort. Objectives A report from the International Spine Study Group (ISSG) noted that surgeons failed to achieve alignment goals in nearly two-thirds of 266 complex adult deformity surgery (CADS) cases. We assess whether personalized interbody spacers are associated with improved rates of achieving goal alignment following adult spinal deformity (ASD) surgery. Methods ASD patients were included if their surgery utilized 3D-printed personalized interbody spacer(s) and they met ISSG CADS inclusion criteria. Planned alignment was personalized by the surgeon during interbody planning. Planned vs achieved alignment was assessed and compared with the ISSG CADS series that used stock interbodies. Results For 65 patients with personalized interbodies, 62% were women, mean age was 70.3 years (SD = 8.3), mean instrumented levels was 9.9 (SD = 4.1), and the mean number of personalized interbodies per patient was 2.2 (SD = .8). Segmental alignment was achieved close to plan for levels with personalized interbodies, with mean difference between goal and achieved as follows: intervertebral lordosis = .9° (SD = 5.2°), intervertebral coronal angle = .1° (SD = 4.7°), and posterior disc height = −0.1 mm (SD = 2.3 mm). Achieved pelvic incidence-to-lumbar lordosis mismatch (PI-LL) correlated significantly with goal PI-LL (r = .668, P < .001). Compared with the ISSG CADS cohort, utilization of personalized interbodies resulted in significant improvement in achieving PI-LL <5° of plan ( P = .046) and showed a significant reduction in cases with PI-LL >15° of plan ( P = .012). Conclusions This study supports use of personalized interbodies as a means of better achieving goal segmental sagittal and coronal alignment and significantly improving achievement of goal PI-LL compared with stock devices.
Is Age a Risk Factor for Early Postoperative Cage Subsidence After Transforaminal Lumbar Interbody Fusion? A Retrospective Study in 170 Patients
Authors: Zhang Yuancheng , Nüesch Corina , Mündermann Annegret , Halbeisen Florian , Schären Stefan , Netzer Cordula 
Published: November 2023

Study Design Retrospective observational study. Objectives We aim to evaluate whether age is a risk factor for cage subsidence, and whether other patient characteristics, preoperative radiological or imaging parameters are associated with cage subsidence and the need for revision surgery in patients undergoing transforaminal lumbar interbody fusion (TLIF). Methods Patient demographics and surgery-related information were extracted. Cage subsidence was evaluated using upright standing sagittal plane X-rays and defined as more than 2 mm migration of the cage into the adjacent vertebral body. Patients who received revision surgery within 1 year for any reason were recorded. Radiographic parameters were measured. Univariable logistic regression models were used to evaluate the risk factors for cage subsidence and need for revision surgery. Results At 3-month and 1-year follow-up, cage subsidence was observed in 28 patients (16.5%) and 58 patients (34.1%), respectively. Twenty-seven patients received revision surgery within the first year after TLIF. Age (odds ratio (OR): 1.07 per year) and male sex (OR: 2.76) had a significantly increased odds ratio for cage subsidence 3 months after TLIF. Male sex (OR: 2.55) but not age was a significant risk factor for cage subsidence 1 year after TLIF. Of all assessed risk factors, only BMI (OR: 1.11 per kg/m2) had a significantly increased risk for the need of revision surgery. Conclusions Age was associated with cage subsidence 3 months but not 1 year after TLIF suggesting that age is only a risk factor for early cage subsidence and not in a longer follow-up.
Development of a predictive model to distinguish prostate cancer from benign prostatic hyperplasia by integrating serum glycoproteomics and clinical variables
Authors: Gabriele Caterina , Aracri Federica , Prestagiacomo Licia Elvira , Rota Maria Antonietta , Alba Stefano , Tradigo Giuseppe , Guzzi Pietro Hiram , Cuda Giovanni , Damiano Rocco , Veltri Pierangelo , Gaspari Marco 
Published: November 2023

Abstract
Background
Prostate Cancer (PCa) represents the second leading cause of cancer-related death in men. Prostate-specific antigen (PSA) serum testing, currently used for PCa screening, lacks the necessary sensitivity and specificity. New non-invasive diagnostic tools able to discriminate tumoral from benign conditions and aggressive (AG-PCa) from indolent forms of PCa (NAG-PCa) are required to avoid unnecessary biopsies.

Methods
In this work, 32 formerly N-glycosylated peptides were quantified by PRM (parallel reaction monitoring) in 163 serum samples (79 from PCa patients and 84 from individuals affected by benign prostatic hyperplasia (BPH)) in two technical replicates. These potential biomarker candidates were prioritized through a multi-stage biomarker discovery pipeline articulated in: discovery, LC-PRM assay development and verification phases. Because of the well-established involvement of glycoproteins in cancer development and progression, the proteomic analysis was focused on glycoproteins enriched by TiO2 (titanium dioxide) strategy.

Results
Machine learning algorithms have been applied to the combined matrix comprising proteomic and clinical variables, resulting in a predictive model based on six proteomic variables (RNASE1, LAMP2, LUM, MASP1, NCAM1, GPLD1) and five clinical variables (prostate dimension, proPSA, free-PSA, total-PSA, free/total-PSA) able to distinguish PCa from BPH with an area under the Receiver Operating Characteristic (ROC) curve of 0.93. This model outperformed PSA alone which, on the same sample set, was able to discriminate PCa from BPH with an AUC of 0.79.
To improve the clinical managing of PCa patients, an explorative small-scale analysis (79 samples) aimed at distinguishing AG-PCa from NAG-PCa was conducted. A predictor of PCa aggressiveness based on the combination of 7 proteomic variables (FCN3, LGALS3BP, AZU1, C6, LAMB1, CHL1, POSTN) and proPSA was developed (AUC of 0.69).

Conclusions
To address the impelling need of more sensitive and specific serum diagnostic tests, a predictive model combining proteomic and clinical variables was developed. A preliminary evaluation to build a new tool able to discriminate aggressive presentations of PCa from tumors with benign behavior was exploited. This predictor displayed moderate performances, but no conclusions can be drawn due to the limited number of the sample cohort.
Data are available via ProteomeXchange with identifier PXD035935.
High-intensity interval training alleviates exhaustive exercise-induced HSP70-assisted selective autophagy in skeletal muscle
Authors: Lu Jiao , Zhang Liu-mei , Liu Jing-jing , Liu Yu-ting , Lin Xiao-ye , Wang Xue-qi , Zhang Yuan , Tang Qiang , Liu Lin 
Published: November 2023

AbstractThis study was designed to probe the effect of chaperone-assisted selective autophagy (CASA) on the maintenance of proteostasis during exhaustive exercise and uncover the alteration of CASA in muscle fibers with pre-high-intensity interval training (HIIT) intervention-induced muscle adaptation in response to exhaustive exercise. Rats were randomly divided into a control group; an exhaustive exercise group; and an HIIT + exhaustive exercise group. Results show myofibril damage and BiP levels were increased after exhaustive exercise, and the levels of the HSP70, BAG3, ubiquitin, autophagy-related proteins, and their interactions were increased. HIIT intervention before exhaustive exercise could decrease myofibril injury and BiP levels, accompanied by down-regulation of HSP70/BAG3 complex and selective autophagy. In conclusion, exhaustive exercise promotes CASA to clear protein aggregation for keeping proteostasis in muscle fibers; pre-HIIT intervention improves myofibril injury and unfold protein response caused by exhaustive exercise, which might contribute to inhibit the augmentation of CASA.
Mycorrhizas and Trichoderma fungi increase the accumulation of secondary metabolites in grain legume leaves and suppress foliar diseases in field-grown conditions of the humid forest of Cameroon
Authors: Jemo Martin , Nkenmegne Severin , Buernor Alfred Balenor , Raklami Anas , Ambang Zachee , Souleyamanou Adamou , Ouhdouch Yedir , Hafidi Mohamed 
Published: November 2023

Abstract
Background
Arbuscular mycorrhizal and Trichoderma fungi alter the synthesis of secondary metabolites of plants and confer tolerance from pathogens attacks. However, there is less supportive evidence from on-field studies confirming the above-mentioned hypothesis, particularly for the humid forest zone of Cameroon where pathogens are important sources of yield losses for legumes such as soybean and common bean.

Materials and methods
We evaluated the impacts of mycorrhiza isolates of Rhizophagus intraradices (Ri) and Trichoderma asperellum (Ta) fungi and their co-inoculations (Ta x Ri) in the synthetizing of leaves secondary metabolites, foliar disease symptoms, growth, N and P uptake, and yields of three genotypes of soybean (TGx 1485-1D, TGx 1990-93 F, and TGx 1990-97 F) and common beans (NUA-99, DOR-701, and PNN) under field conditions of Cameroon.

Results
We found that common bean plants showed a lower foliar infection rate but a higher increase in root colonization intensity, shoot dry weight, and N and P uptakes than soybeans when inoculated with Ri and Ta treatment. However, the grain yield of soybean soybean was higher (2000 kg ha 1) than the common bean plants for the Ri × Ta treatment. The soybean genotype TGx 1990-93F had increased root colonization intensity and the lowest foliar infection rate, making it stronger and tolerant to pathogen attacks when co-inoculated with Ri × Ta fungi (F). Bean plants inoculated with Ri and the co-inoculated with Ri × Ta demonstrated lower symptoms of foliar attack, and increased root colonization, particularly the PNN variety. The total amino acid and proline accumulations were higher for soybean than common bean plants due to fungi inoculations, and soybean genotypes accumulated more excellent contents of amino acid and proline in the control (10.1 mg g− 1 fwt) that significantly increased under the Ri × Ta inoculation (13.4 mg g− 1 fwt).

Conclusions
Common bean plants inoculated with Ta and Ri fungi accumulated higher phenolic compounds in their leaves that aided them in overcoming the pathogen attacks than soybean plants.
Ocular involvement in pediatric Behçet’s disease: is it different than in adults? (a short case series and mini review)
Authors: Azri Casem , Dusser Perrine , Eid Laura , Barreau Emmanuel , Kone-Paut Isabelle , Borocco Charlotte , Galeotti Caroline , Saad Sami , Labetoulle Marc , Rousseau Antoine 
Published: November 2023

Abstract
Background
Pediatric Behçet’s disease (PBD) is rarer than BD and can be a challenging diagnosis as clinical picture may be incomplete. As in adult patients, sight-threatening ocular manifestations may lead to diagnosis. In this study, we aimed to report a series of cases of PBD with ocular manifestations and provide a review of the literature.

Methods
Retrospective case series of PBD patients with ocular manifestations. Demographic, ophthalmological and systemic data at presentation and during follow-up were collected and analyzed.

Results
Four patients, aged 13.0 ± 2.9 years (9–16) were included. Posterior uveitis with retinal vasculitis, papillitis and macular edema was present in all patients, with associated anterior uveitis in 2 cases. Other features included occlusive vasculitis (2/4) and necrotizing retinitis (2/4). All patients were improved by systemic treatments except one patient with severe bilateral optic neuropathy. Ocular manifestations were the presenting symptoms in 3/4 cases.

Conclusion
Ocular manifestations and systemic associations of PBD are comparable to those encountered in adult patients. The lack of complains in pediatric patients may lead to a longer diagnosis delay, especially in unilateral uveitis. Aggressive and long-term treatment is mandatory to prevent vision loss and recurrences.