bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complexity of Waste Handling Technology at Final Disposal Site of Bantargebang, Bekasi City
Authors: Ardiatma Dodit , Lestari Puji , Chaerul Mochammad 
Published: November 2023

Abstract
Major problems at final waste processing sites (TPAs) include leachate, groundwater pollution, public health, and social aspects. Landfills are a major contributor to environmental damage in the world with effects on warming, acidification, smog formation, eutrophication, ecotoxicity and cancer to human health and non-cancer categories. Waste management in D.K.I Jakarta Province is currently facing a shortage of Integrated Waste Management Site (TPST) space with waste production reaching 7,000 to 7,500 tons/day. The main challenge in today’s municipal solid waste management is the selection of the most appropriate waste processing scenario, where the chosen method must be efficient and effective in minimizing leaching and emissions and reducing landfill waste, so that the service life of final disposal will be longer. Final disposal Bantargebang is the largest final disposal in Indonesia with an area of 132,5 Ha, where 80% is used for waste management and 20% of the land is used for support facilities. Final disposal Bantargebang implements various technologies in waste management including landfill, PLTSA, composting, and refuse-derived fuel (RDF) and involves scavengers in waste management at final disposal Bantargebang. The most dominant type of waste is food waste which reaches 39%. Various current technologies are still not effective, the implementation of sanitary landfills in final disposal Bantargebang is still very difficult to meet the planned design criteria, and tends to implement open dumping. This increases the potential for groundwater and surface water pollution and contributes to increased GHGs. Surface water in final disposal Bantargebang is highly polluted with COD and BOD parameters that exceed quality standards. Therefore, the multi-technology applied at final disposal Bantargebang only achieves an efficiency of 8% of incoming waste and the rest is still landfill waste in the landfill zone which is 92%.
Flexible and stretchable synaptic devices for wearable neuromorphic electronics
Authors: Lee Hyeon-Soo , Ro Jun-Seok , Ko Gyu-Min , Park Hea-Lim 
Published: November 2023

Abstract
Wearable neuromorphic devices have gained attention because of the growth in the Internet of Things and the increasing demand for health monitoring. They provide meaningful information and interact with the external environment through physiological signal processing and seamless interaction with the human body. The concept of these devices originated from the development of neuromorphic and flexible/stretchable electronics, which offer a solution to the limitation of conventional rigid devices. They have been developed to mimic synaptic functions and flexibility/stretchability of the biological nervous system. In this study, we described the various synaptic properties that should be implemented in synaptic devices and the operating mechanisms that exhibit these properties with respect to two- and three-terminal devices. Further, we specified comprehensive methods of implementing mechanical flexibility and stretchability in neuromorphic electronics through both structure and material engineering. In addition, we explored various wearable applications of these devices, such as wearable sensors for danger detection, auxiliary equipment for people with sensory disabilities, and neuroprosthetic devices. We expect this review to provide an overall understanding of concepts and trends for flexible and stretchable neuromorphic devices, with potential extensions to state-of-the-art applications such as cybernetics and exoskeleton.
Quantum logical controlled-NOT gate in a lithium niobate-on-insulator photonic quantum walk
Authors: Chapman Robert J , Häusler Samuel , Finco Giovanni , Kaufmann Fabian , Grange Rachel 
Published: November 2023

Abstract
The two-qubit controlled-NOT gate is one of the central entangling operations in quantum information technology. The controlled-NOT gate for single photon qubits is normally realized as a network of five individual beamsplitters on six optical modes. Quantum walks (QWs) are an alternative photonic architecture involving arrays of coupled waveguides, which have been successful for investigating condensed matter physics, however, have not yet been applied to quantum logical operations. Here, we engineer the tight-binding Hamiltonian of an array of lithium niobate-on-insulator waveguides to experimentally demonstrate the two-qubit controlled-NOT gate in a QW. We measure the two-qubit transfer matrix with 0.938 ± 0.003 fidelity, and we use the gate to generate entangled qubits with 0.945 ± 0.002 fidelity by preparing the control photon in a superposition state. Our results highlight a new application for QWs that use a compact multi-mode interaction region to realize large multi-component quantum circuits.
Fc gamma receptors promote antibody-induced LILRB4 internalization and immune regulation of monocytic AML
Authors: Morse Joshua W , Gui Xun , Deng Mi , Huang Ryan , Ye Xiaohua , Zhao Peng , Fan Xuejun , Xiong Wei , Zhang Chengcheng , Zhang Ningyan , An Zhiqiang 
Published: November 2023

Abstract
The immune checkpoint leukocyte immunoglobulin-like receptor B4 (LILRB4) is found specifically on the cell surface of acute monocytic leukemia (monocytic AML), an aggressive and common subtype of AML. We have developed a humanized monoclonal IgG1 LILRB4-blocking antibody (h128-3), which improved immune regulation but reduced cell surface expression of LILRB4 in monocytic AML models by 40–60%. Interestingly, most of this effect was neutralized by mutation of the Fc region of the antibody (h128-3/N297A), which prevents interaction with Fc gamma receptors (FcγRs). This suggested that there is FcγR-dependent antigenic modulation underlying h128-3’s effects, a mechanism known to alter the function of antibodies targeting B-cell malignancies. We disrupted the Fc-FcγR interaction pharmacologically and with stable CRISPR-Cas9-mediated genetic knockout of FcγRs in monocytic AML cell lines to investigate the role of FcγR-dependent antigenic modulation in the regulation of LILRB4 by h128-3. When FcγRI is inhibited or removed from the surface of monocytic AML cells, h128-3 cannot optimally perform its blocking function, resulting in activation of the LILRB4 inhibitory receptor and leading to a 15–25% decrease in T-cell-mediated cytotoxicity in vitro. In the absence of FcγRI, scaffolding by FcγRIIa allows h128-3 to maintain LILRB4-blocking function. Here we define a FcγR-dependent antigenic modulation mechanism underlying the function of an immunoreceptor blocking antibody for the first time in myeloid malignancy. This research will facilitate the development of safe, precision-targeted antibody therapeutics in myeloid malignancies with greater potency and efficacy.
The International Recognition of Governments in Practice(s): Creatures, Mirages, and Dilemmas in Post-2011 Libya
Authors: Fernández-Molina Irene 
Published: November 2023

AbstractThe international (non)recognition of governments is a composite macro practice that has grown in visibility in recent years in response to contentious domestic political processes such as coups d’état, revolutions, and civil wars, yet it remains understudied in international relations. Doctrinal debates in international law and foreign policy reveal the normative vacuum and normative competition that have long surrounded this phenomenon, but say little about its specific operation and effects. This article brings together insights from recognition theory and international practice theory, and uses post-2011 Libya as an in-depth case study, drawing on elite interviews with diplomats, international officials, and other practitioners. The aim is to sketch a new research agenda by building a generalizable typology of smaller-scale government recognition micro practices (declaratory, diplomatic, informal engagement, intergovernmental cooperation, and support practices), and uncovering their guiding logics and consequences. I argue that, first, the international (non)recognition of governments is endowed with a distinct generative power, as it produces its own creatures through a range of micro practices that have identity formation and change, material empowerment, political legitimation, and sovereignty line-drawing effects. Secondly, it is geopolitically inevitable, as external actors involved in a country cannot ultimately avoid engaging with territorially grounded domestic political actors. Thirdly, it is not a black-and-white situation, as it involves a broad variety of practices guided by different, often contradictory logics. Finally, international government recognition practices are likely to run into three dilemmas stemming from three tensions: international versus domestic recognition, legitimacy versus effectiveness, and coherence versus inclusivity in conflict mediation.
A Bibliometric Analysis of the Trends and Evolution on Inhalation Injury Research
Authors: Huang Shengyu , Miao Yinshui , Wang Yusong , Ma Qimin , Liu Xiaobin , Shen Tuo , Zhu Zhihao , Li Jiaqi , Zhu Feng , Guo Guanghua 
Published: November 2023

Abstract
Inhalation injury is a common complication in burn patients and is also a factor that can affect the multiple prognoses of burn patients. Attention to inhalation injury began early globally, but few articles have systematically analyzed its development. We employed bibliometric methods to analyze articles on inhalation injury published in 3 medical databases. A total of 3056 relevant articles on inhalation injury were included in our analysis and divided into 3 distinct periods based on Price’s law. Notably, a slowdown in publication growth was observed in period III. The majority of these articles were authored by a small group of individuals, with a significant proportion of them being American scholars. In fact, nearly half of the articles were published by American researchers. Applying Bradford’s Law, we identified 4 major output sources in the field, namely Burns, Journal of Burn Care & Research, Journal of Trauma, and Critical Care Medicine. Recent research has focused on the clinical risks and outcomes associated with inhalation injury, while basic research in this area has been relatively neglected over the last decade. In conclusion, the growth of publications on inhalation injuries has largely followed standard scientific growth patterns, with a small number of countries and established research groups contributing the majority of articles. However, the recent slowdown in scientific output is a cause for concern, and the lack of emphasis on basic research and clinical trials in this field raises questions about the foundation for widespread clinical management of inhalation injuries.
GenoPipe: identifying the genotype of origin within (epi)genomic datasets
Authors: Lang Olivia W , Srivastava Divyanshi , Pugh B Franklin , Lai William K M 
Published: November 2023

Abstract
Confidence in experimental results is critical for discovery. As the scale of data generation in genomics has grown exponentially, experimental error has likely kept pace despite the best efforts of many laboratories. Technical mistakes can and do occur at nearly every stage of a genomics assay (i.e. cell line contamination, reagent swapping, tube mislabelling, etc.) and are often difficult to identify post-execution. However, the DNA sequenced in genomic experiments contains certain markers (e.g. indels) encoded within and can often be ascertained forensically from experimental datasets. We developed the Genotype validation Pipeline (GenoPipe), a suite of heuristic tools that operate together directly on raw and aligned sequencing data from individual high-throughput sequencing experiments to characterize the underlying genome of the source material. We demonstrate how GenoPipe validates and rescues erroneously annotated experiments by identifying unique markers inherent to an organism's genome (i.e. epitope insertions, gene deletions and SNPs).
PPGR: a comprehensive perennial plant genomes and regulation database
Authors: Yang Sen , Zong Wenting , Shi Lingling , Li Ruisi , Ma Zhenshu , Ma Shubao , Si Jingna , Wu Zhijing , Zhai Jinglan , Ma Yingke , Fan Zhuojing , Chen Sisi , Huang Huahong , Zhang Deqiang , Bao Yiming , Li Rujiao , Xie Jianbo 
Published: November 2023

Abstract
Perennial woody plants hold vital ecological significance, distinguished by their unique traits. While significant progress has been made in their genomic and functional studies, a major challenge persists: the absence of a comprehensive reference platform for collection, integration and in-depth analysis of the vast amount of data. Here, we present PPGR (Resource for Perennial Plant Genomes and Regulation; https://ngdc.cncb.ac.cn/ppgr/) to address this critical gap, by collecting, integrating, analyzing and visualizing genomic, gene regulation and functional data of perennial plants. PPGR currently includes 60 species, 847 million protein–protein/TF (transcription factor)-target interactions, 9016 transcriptome samples under various environmental conditions and genetic backgrounds. Noteworthy is the focus on genes that regulate wood production, seasonal dormancy, terpene biosynthesis and leaf senescence representing a wealth of information derived from experimental data, literature mining, public databases and genomic predictions. Furthermore, PPGR incorporates a range of multi-omics search and analysis tools to facilitate browsing and application of these extensive datasets. PPGR represents a comprehensive and high-quality resource for perennial plants, substantiated by an illustrative case study that demonstrates its capacity in unraveling gene functions and shedding light on potential regulatory processes.
Emergency communications after earthquake reveal social network backbone of important ties
Authors: Jia Jayson S , Li Yiwei , Liu Sheng , Christakis Nicholas A , Jia Jianmin 
Published: November 2023

Abstract
Social networks provide a basis for collective resilience to disasters. Combining the quasi-experimental context of a major earthquake in Ya’an, China, with anonymized mobile telecommunications records regarding 91,839 Ya’an residents, we use initial bursts of postdisaster communications (e.g. choice of alter, order of calls, and latency) to reveal the “important ties” that form the social network backbone. We find that only 26.8% of important ties activated during the earthquake were the strongest ties during normal times. Many important ties were hitherto latent and weak, only to become persistent and strong after the earthquake. We show that which ties activated during a sudden disaster are best predicted by the interaction of embeddedness and tie strength. Moreover, a backbone of important ties alone (without the inclusion of weak ties ordinarily seen as important to bridge communities) is sufficient to generate a hierarchical structure of social networks that connect a disaster zone's disparate communities.
Best billiard ball in the 19th century: Composite materials made of celluloid and bone as substitutes for ivory
Authors: Neves Artur , Friedel Robert , Melo Maria J , Callapez Maria Elvira , Vicenzi Edward P , Lam Thomas 
Published: November 2023

AbstractThe demystification of how 19th-century novelly designed materials became significant elements of modern technological, economic, and cultural life requires a complete understanding of the material dimensions of historical artifacts. The objects frequently described as the earliest manufactured plastic products—the billiard balls made by John Wesley Hyatt and his associates from the late 1860s—are examined closely for the first time and are found to be more complex and functionally more successful than has been described. Modern analytical techniques such as optical microscopy, scanning electron microscope—energy dispersive X-ray spectroscopy, X-ray fluorescence, micro-Fourier transformed infrared, and handheld/micro-Raman spectroscopies were used to reveal the complex composition of the Smithsonian Institution's “original” 1868 celluloid billiard ball. Comparisons with billiard and pool balls commercialized from the 1880s to the 1960s showed an unexpected consistency in material formulations. All specimens were made of an unprecedented composite material prepared with a mixture of cellulose nitrate, camphor, and ground bone; the source of the bone was identified as cattle by peptide mass fingerprint (ZooMS). Patent specifications and contemporary journal descriptions explained how and when these formulations emerged. Combining the technical analyses of compositions with a careful reading of the historical record and contemporary descriptions reveals the key elements of the first successful efforts to substitute materials to assist the survival of endangered animals.
Health of unpaid carers in Wales, UK: a population data linkage study
Authors: Huang Fangzhou , Song Jiao , Davies Alisha R 
Published: November 2023

Abstract

Background
The population of unpaid carers in Wales increased to record. There is no systematic approach to record unpaid caring status, resulting in limited quantitative evidence on unpaid carers’ health. The aim of this study is to: (i) create an e-cohort of unpaid carers by linking routinely collected health and administrative datasets in Wales, UK. (ii) investigate whether long-term health conditions and multimorbidity are more prevalent amongst unpaid carers than non-carers.

Methods
Unpaid carers were identified by linking primary care dataset, National Survey for Wales data with demographic characteristics in the Secure Anonymise Information Linkage Databank. The clinical codes identified in Cambridge Multimorbidity Score were used to explore the prevalence of long-term health conditions.

Results
A total of 91 220 unpaid carers in Wales were identified between 1 January 2010 and 1 March 2022. Unpaid carers were found at higher risk of managing 35 of 37 long-term health conditions and multimorbidity than non-carers, exacerbated amongst younger age groups and deprived communities.

Conclusions
The creation of the first e-cohort of unpaid carers in Wales provides opportunities to perform rapid analysis to systematically understand health needs and evaluate initiatives in future. To better support unpaid carers, flexible approaches focusing on early identification and prevention is crucial.
Increased mortality rate in Takayasu arteritis is largely driven by cardiovascular disease: a cohort study
Authors: Jagtap Swapnil , Mishra Prabhaker , Rathore Upendra , Thakare Darpan R , Singh Kritika , Dixit Juhi , Qamar Tooba , Behera Manas Ranjan , Jain Neeraj , Ora Manish , Bhadauria Dharmendra Singh , Gambhir Sanjay , Kumar Sudeep , Agarwal Vikas , Misra Durga Prasanna 
Published: November 2023

Abstract

Objectives
To analyse the risk, causes and predictors of mortality in Takayasu arteritis (TAK).

Methods
Survival was assessed in a cohort of patients with TAK using Kaplan–Meier curves. Age- and sex-standardized mortality ratio (SMR = observed: expected deaths) for TAK were calculated by applying age- and sex-specific mortality rates for the local population to calculate expected deaths. Hazard ratios (HR with 95%CI) for predictors of mortality based on demographic characteristics, presenting features, baseline angiographic involvement, disease activity, number of immunosuppressive medications used, procedures related to TAK and any serious infection were calculated using Cox regression or exponential parametric regression models.

Results
Among 224 patients with TAK (159 females, mean follow-up duration 44.36 months), survival at 1, 2, 5 and 10 years was 97.34%, 96.05%, 93.93% and 89.23%, respectively. Twelve deaths were observed, most of which were due to cardiovascular disease (heart failure, myocardial infarction, stroke). Mortality risk was significantly higher with TAK (SMR 17.29, 95%CI 8.95–30.11) than the general population. Earlier age at disease onset (HR 0.90, 95%CI 0.83–0.98; or pediatric-onset vs adult-onset disease, HR 5.51, 95%CI 1.57–19.32), higher disease activity scores (ITAS2010: HR 1.15, 95%CI 1.05–1.25, DEI.TAK: HR 1.18, 95%CI 1.08–1.29), any serious infections (HR 5.43, 95%CI 1.72–17.12), heart failure (HR 7.83, 95%CI 2.17–28.16) or coeliac trunk involvement at baseline (HR 4.01, 95%CI 1.26–12.75) were associated with elevated mortality risk.

Conclusion
Patients with TAK had an elevated risk of mortality as compared with the general population. Cardiovascular disease was the leading cause of death in TAK.
Frontal mechanisms underlying primate calls recognition by humans
Authors: Ceravolo Leonardo , Debracque Coralie , Pool Eva , Gruber Thibaud , Grandjean Didier 
Published: November 2023

Abstract

Introduction
The ability to process verbal language seems unique to humans and relies not only on semantics but on other forms of communication such as affective vocalizations, that we share with other primate species—particularly great apes (Hominidae).

Methods
To better understand these processes at the behavioral and brain level, we asked human participants to categorize vocalizations of four primate species including human, great apes (chimpanzee and bonobo), and monkey (rhesus macaque) during MRI acquisition.

Results
Classification was above chance level for all species but bonobo vocalizations. Imaging analyses were computed using a participant-specific, trial-by-trial fitted probability categorization value in a model-based style of data analysis. Model-based analyses revealed the implication of the bilateral orbitofrontal cortex and inferior frontal gyrus pars triangularis (IFGtri) respectively correlating and anti-correlating with the fitted probability of accurate species classification. Further conjunction analyses revealed enhanced activity in a sub-area of the left IFGtri specifically for the accurate classification of chimpanzee calls compared to human voices.

Discussion
Our data—that are controlled for acoustic variability between species—therefore reveal distinct frontal mechanisms that shed light on how the human brain evolved to process vocal signals.
The urothelial barrier in interstitial cystitis/bladder pain syndrome: its form and function, an overview of preclinical models
Authors: van Ginkel Charlotte , Hurst Robert E. , Janssen Dick 
Published: November 2023

Purpose of review
Investigating bladder pain syndrome/interstitial cystitis (IC/BPS) preclinically is challenging. Various research models have been used to mimic the urothelial barrier closely and replicate the disease. The aim of this review is to discuss preclinical research related to the urothelial barrier in context of IC/BPS.

Recent findings
In vivo models mimic IC/BPS mainly with toxic substances in the urine, with protaminesulfate and proteoglycan deglycolysation resembling a temporary impaired barrier as seen in IC/BPS. This temporary increased permeability has also been found in vitro models. Glycosaminoglycan replenishment therapy has been described, in vivo and in vitro, to protect and enhance recover properties of the urothelium. The roles of immune and neurogenic factors in the pathogenesis of IC/BPS remains relatively understudied.

Summary
Preclinical studies provide opportunities to identify the involvement of specific pathologic pathways in IC/BPS. For further research is warranted to elucidate the primary or secondary role of permeability, together with inflammatory and neurogenic causes of the disease.