bluuebunny/crossref_metadata_2025_split huggingface dataset:
Susceptibility vessel sign, a predictor of long-term outcome in patients with stroke treated with mechanical thrombectomy
Authors: Beyeler Morin , Rea Erich , Weber Loris , Belachew Nebiyat Filate , Barvulsky Aleman Enrique , Kielkopf Moritz , Kurmann Christoph C , Grunder Lorenz , Piechowiak Eike Immo I , Meinel Thomas R , Heldner Mirjam R , Seiffge David , Pilgram-Pastor Sara , Dobrocky Tomas , Pabst Thomas , Berger Martin D , Jung Simon , Arnold Marcel , Gralla Jan , Fischer Urs , Kaesmacher Johannes , Mujanovic Adnan 
Published: November 2023

Background
The absence of the susceptibility vessel sign (SVS) in patients treated with mechanical thrombectomy (MT) is associated with poor radiological and clinical outcomes after 3 months. Underlying conditions, such as cancer, are assumed to influence SVS status and could potentially impact the long-term outcome. We aimed to assess SVS status as an independent predictor of long-term outcomes in MT-treated patients.

Methods
SVS status was retrospectively determined in consecutive MT-treated patients at a comprehensive stroke center between 2010 and 2018. Predictors of long-term mortality and poor functional outcome (modified Rankin Scale (mRS) ≥3) up to 8 years were identified using multivariable Cox and logistic regression, respectively.

Results

Of the 558 patients included, SVS was absent in 13% (n=71) and present in 87% (n=487) on baseline imaging. Patients without SVS were more likely to have active cancer (P
=
0.003) and diabetes mellitus (P
<
0.001) at the time of stroke. The median long-term follow-up time was 1058 days (IQR 533–1671 days). After adjustment for active cancer and diabetes mellitus, among others, the absence of SVS was associated with long-term mortality (adjusted HR (aHR) 2.11, 95% CI 1.35 to 3.29) and poor functional outcome in the long term (adjusted OR (aOR) 2.90, 95% CI 1.29 to 6.55).

Conclusion
MT-treated patients without SVS have higher long-term mortality rates and poorer long-term functional outcome. It appears that this association cannot be explained by comorbidities alone, and further studies are warranted.
Chemical shift tensors as probes of chalcogen bonds: solid-state NMR study of telluradiazole-XCN− (X = O, S, Se) salt cocrystals
Authors: Almario Carina , Nag Tamali , Bryce David L. 
Published: November 2023

We report experimental 125Te magic-angle spinning solid-state nuclear magnetic resonance (MAS NMR) measurements of the tellurium chemical shift (CS) tensors in three [K(18-crown-6)]+ 3,4-dicyano-1,2,5-telluradiazole-XCN− (X = O, S, Se) salt cocrystals featuring chalcogen bonds. These data are compared to those for pure 3,4-dicyano-1,2,5-telluradiazole (1). A reduction in the span of the 125Te CS tensor is consistently noted in the salt cocrystals compared to pure 1. Isotopically 15N-labelled [K(18-crown-6)]+[1-OC15N]−, which features a chalcogen bond between Te and the cyanate nitrogen atom, is synthesized using KOC15N, and the nitrogen CS tensors are measured for both samples via 15N slow MAS NMR spectroscopy. Possible dynamic disorder of the cyanate ions in KOCN is ruled out. Two crystallographically distinct nitrogen sites are resolved for the salt cocrystal. Upon formation of [K(18-crown-6)]+[1-OC15N]−, the 15N isotropic CS and CS tensor span both decrease relative to the values for pure KOC15N, and the axial symmetry of this tensor is lost. These findings are supplemented with a series of density functional theory calculations of magnetic shielding tensors using cluster models or periodic boundary conditions. Inclusion of spin–orbit relativistic effects in the calculation of tellurium shielding tensors is particularly important in achieving agreement with experiment.
Gravitational baryogenesis in non-minimal kinetic coupling model
Authors: Goodarzi Parviz 
Published: November 2023

AbstractIn this work, we consider the gravitational baryogenesis in the framework of non-minimal derivative coupling model. A mechanism to generate the baryon asymmetry based on the coupling between the derivative of the Ricci scalar curvature and the baryon current in context of non-minimal derivative coupling model is investigated. We show that, in this model, the temperature increases during the reheating periods to the end of reheating period or beginning of radiation dominated era. Therefore the reheating temperature is larger then decoupling temperature. It can be demonstrated that, the evaluation of baryon asymmetry is not depends on coupling constant. In this model we can generate baryon asymmetry at low and high reheating temperature, by considering the high friction constraint.
State Complexity of Permutation and the Language Inclusion Problem up to Parikh Equivalence on Alphabetical Pattern Constraints and Partially Ordered NFAs
Authors: Hoffmann Stefan 
Published: November 2023

We investigate the state complexity of the permutation operation, or the commutative closure, on Alphabetical Pattern Constraints (APCs). This class corresponds to level [Formula: see text] of the Straubing-Thérien hierarchy and includes the finite, the piecewise testable, or [Formula: see text]-trivial, and the [Formula: see text]-trivial and [Formula: see text]-trivial languages. We give a sharp state complexity bound expressed in terms of the longest strings in the unary projection languages of an associated finite language. Additionally, for a subclass, we give sharp bounds expressed in terms of the size of a recognizing input automaton and the size of the alphabet. We also state a related state complexity bound for the commutative closure on finite languages. Lastly, we investigate the language inclusion, equivalence and universality problems on APCs up to permutational, or Parikh, equivalence. These problems are known to be [Formula: see text]-complete on APCs in general, even for fixed alphabets. We show them to be decidable in polynomial time for fixed alphabets if we only want to solve them up to Parikh equivalence. We also correct a mistake from the conference version in a bound on the size of recognizing automata for the commutative closure.
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia
Authors: Varkaris Andreas , Pazolli Ermira , Gunaydin Hakan , Wang Qi , Pierce Levi , Boezio Alessandro A. , Bulku Artemisa , DiPietro Lucian , Fridrich Cary , Frost Adam , Giordanetto Fabrizio , Hamilton Erika P. , Harris Katherine , Holliday Michael , Hunter Tamieka L. , Iskandar Amanda , Ji Yongli , Larivée Alexandre , LaRochelle Jonathan R. , Lescarbeau André , Llambi Fabien , Lormil Brenda , Mader Mary M. , Mar Brenton G. , Martin Iain , McLean Thomas H. , Michelsen Klaus , Pechersky Yakov , Puente-Poushnejad Erika , Raynor Kevin , Rogala Dipali , Samadani Ramin , Schram Alison M. , Shortsleeves Kelley , Swaminathan Sweta , Tajmir Shahein , Tan Gege , Tang Yong , Valverde Roberto , Wehrenberg Bryan , Wilbur Jeremy , Williams Bret R. , Zeng Hongtao , Zhang Hanmo , Walters W. Patrick , Wolf Beni B. , Shaw David E. , Bergstrom Donald A. , Watters James , Fraser James S. , Fortin Pascal D. , Kipp D. Randal 
Published: November 2023

Abstract

PIK3CA (PI3Kα) is a lipid kinase commonly mutated in cancer, including ∼40% of hormone receptor–positive breast cancer. The most frequently observed mutants occur in the kinase and helical domains. Orthosteric PI3Kα inhibitors suffer from poor selectivity leading to undesirable side effects, most prominently hyperglycemia due to inhibition of wild-type (WT) PI3Kα. Here, we used molecular dynamics simulations and cryo-electron microscopy to identify an allosteric network that provides an explanation for how mutations favor PI3Kα activation. A DNA-encoded library screen leveraging electron microscopy-optimized constructs, differential enrichment, and an orthosteric-blocking compound led to the identification of RLY-2608, a first-in-class allosteric mutant-selective inhibitor of PI3Kα. RLY-2608 inhibited tumor growth in PIK3CA-mutant xenograft models with minimal impact on insulin, a marker of dysregulated glucose homeostasis. RLY-2608 elicited objective tumor responses in two patients diagnosed with advanced hormone receptor–positive breast cancer with kinase or helical domain PIK3CA mutations, with no observed WT PI3Kα-related toxicities.

Significance:
Treatments for PIK3CA-mutant cancers are limited by toxicities associated with the inhibition of WT PI3Kα. Molecular dynamics, cryo-electron microscopy, and DNA-encoded libraries were used to develop RLY-2608, a first-in-class inhibitor that demonstrates mutant selectivity in patients. This marks the advance of clinical mutant-selective inhibition that overcomes limitations of orthosteric PI3Kα inhibitors.
See related commentary by Gong and Vanhaesebroeck, p. 204 .
See related article by Varkaris et al., p. 227 .
This article is featured in Selected Articles from This Issue, p. 201
Description of Tobriloides sinensis sp. n. (Nematoda: Triplonchida: Tobrilidae) from Shanxi province, north China
Authors: Yang Gurong , Liu Meina , Ma Yibing , Zhao Zengqi , Wang Jianming , Xu Yumei 
Published: November 2023

Summary
Tobriloides sinensis sp. n. is described from Shanxi province, China. It is characterised by relatively long body (1620-1935 m), two subventral teeth posterior to dorsal tooth, a short pharynx (b = 4.2-5.0), cardia three times longer than wide (91-98 μm long and 30-37 μm wide), female reproductive system amphidelphic, the vulva situated slightly posterior to mid-body (V = 59.0-69.9), and the tail relatively short (c = 8.4-9.7 and c′ = 4.6-5.7). The phylogenetic relationships of the new species were analysed using data from the near full length small subunit (SSU) and D2-D3 segments of large subunit (LSU) of rRNA genes. The status of T. sinensis sp. n. is discussed based on both morphological and molecular characteristics.
The Gentleman, the Detective, and the Housewife
Authors: Hsiung Hansun 
Published: November 2023

Abstract
This article examines Japanese experiments concerning the power of “thoughtography,” demonstrating how sensory disagreements between psychologists and physicists were concretized through divergent gendered personae within contested spaces of experiment. Specifically, I analyze thoughtography as a story of conflicts between personae of “gentleman” and “detective” within the private, nuclear-familial home of the “housewife.” In the early twentieth century, the psychological laboratory had yet to establish its authority in Japan. Successful experiment thus required visiting subjects and navigating the intersensorial spaces of their homes. The strategies through which researchers adapted to homes, and the strategies by which housewives manipulated homes to their advantage, reveal contestations over how to look, touch, and feel in the presence of others. They furthermore reveal that the drive to emulate “Western science” met with contradictions in “Westernization” itself, particularly between demands concerning new protocols of masculine scholarly sociability and the prerogatives of the bourgeois wife and mother.
Speaking Xhosa multilingually
Authors: Mesthrie Rajend , Mfazwe-Mojapelo Lulu 
Published: November 2023

Abstract
Although code-switching has been quite well studied as a worldwide phenomenon, closer attention to effects on the more localized language involved is needed, especially in the repertoires of younger, well-educated speakers speaking in a multilingual mode. We argue that their language shows creativity going well beyond older instances of borrowing and code-switching into a “third space” grammar, which shows an active and creative synthesis of at least two languages. This study is based on interview data with 37 speakers of Xhosa in Soweto, South Africa. It focuses on (a) the verb suffix -isha as a marker of multilingual Xhosa par excellence, (b) a new lease of life given to the class 14 prefix ubu- in connection with (mainly) Latinate adjectives from English, and (c) the interchangeability of logical connectors across the third space.
U-Net deep learning model for endoscopic diagnosis of chronic atrophic gastritis and operative link for gastritis assessment staging: a prospective nested case–control study
Authors: Zhao Quchuan , Jia Qing , Chi Tianyu 
Published: November 2023

Background: The operative link for the gastritis assessment (OLGA) system can objectively reflect the stratification of gastric cancer risk in patients with chronic atrophic gastritis (CAG). Objectives: We developed a real-time video monitoring model for the endoscopic diagnosis of CAG and OLGA staging based on U-Net deep learning (DL). To further validate and improve its performance, we designed a study to evaluate the diagnostic evaluation indices. Design: A prospective nested case–control study Methods: Our cohort consisted of 1306 patients from 31 July 2021 to 31 January 2022. According to the pathological results, patients in the cohort were divided into the CAG group and the chronic non-atrophic gastritis group to evaluate the diagnostic evaluation indices. Each atrophy lesion was automatically labeled and the atrophy severity was assessed by the model. Propensity score matching was used to minimize selection bias. Results: The diagnostic evaluation indices and the consistency between OLGA staging and pathological diagnosis of the model were superior to those of endoscopists [sensitivity (89.31% versus 67.56%), specificity (90.46% versus 70.23%), positive predictive value (90.35% versus 69.41%), negative predictive value (89.43% versus 68.40%), accuracy rate (89.89% versus 68.89%), Youden index (79.77% versus 37.79%), odd product (79.23 versus 4.91), positive likelihood ratio (9.36 versus 2.27), negative likelihood ratio (0.12 versus 0.46)], areas under the curves (AUC) (95% CI) (0.919 (0.893–0.945) versus 0.749 (0.707–0.792), p < 0.001) and kappa (0.816 versus 0.291)]. Conclusion: Our study demonstrated that the DL model can assist endoscopists in real-time diagnosis of CAG during gastroscopy and synchronous identification of high-risk OLGA stage (OLGA stages III and IV) patients. Trial registration: ChiCTR2100044458.
Factors for delays in door-to-balloon time ≤ 90 min in an electrocardiogram triage system among patients with ST-segment elevation myocardial infarction: a retrospective study
Authors: Inoue Atsuhito , Mizobe Michiko , Takahashi Jin , Funakoshi Hiraku 
Published: November 2023

Abstract
Background
Door to balloon time is a crucial factor of mortality in patients with ST-segment elevation myocardial infarction. However, the factors that contribute to failure of achieving door to balloon time ≤ 90 min in an electrocardiogram triage system remain unknown.

Methods
This single-center retrospective observational study collected data from consecutive patients with ST-segment elevation myocardial infarction from April 2016 to March 2021. The primary outcome was the failure to achieve door to balloon time ≤ 90 min. A multivariate logistic regression model was performed to predict factors associated with failure to achieve door to balloon time ≤ 90 min.

Results
In total, 190 eligible patients were included. Of these, the 139 (73.2%) patients with door to balloon time ≤ 90 min were significantly younger compared to those with door to balloon time > 90 min (p = 0.02). However, there was no significant difference in sex and timing of hospital arrival between the door to balloon time ≤ 90 and > 90 min groups. Presence of chest pain and ambulance usage were significantly more frequent in patients with door to balloon time ≤ 90 min (p ≤ 0.01, p = 0.02, respectively). Multivariate analysis showed that absence of chest pain (adjusted odds ratio 4.76; 95% confidence interval, 2.04–11.1; p < 0.01) and non-ambulance usage (adjusted odds ratio 3.53; 95% confidence interval, 1.57–7.94; p < 0.01) are predictive factors of failure to achieve door to balloon time ≤ 90 min.

Conclusion
Patients without chest pain as the chief complaint or non-ambulance usage were significantly associated with the failure to achieve door to balloon time ≤ 90 min.
Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits
Authors: Yao Huaibing , Dou Zhihua , Zhao Zhongkai , Liang Xiaorui , Yue Haitao , Ma Wanpeng , Su Zhanqiang , Wang Yuzhuo , Hao Zelin , Yan Hui , Wu Zhuangyuan , Wang Liang , Chen Gangliang , Yang Jie 
Published: November 2023

AbstractBackgroundMilk production traits are complex traits with vital economic importance in the camel industry. However, the genetic mechanisms regulating milk production traits in camels remain poorly understood. Therefore, we aimed to identify candidate genes and metabolic pathways that affect milk production traits in Bactrian camels.MethodsWe classified camels (fourth parity) as low- or high-yield, examined pregnant camels using B-mode ultrasonography, observed the microscopic changes in the mammary gland using hematoxylin and eosin (HE) staining, and used RNA sequencing to identify differentially expressed genes (DEGs) and pathways.ResultsThe average standard milk yield over the 300 days during parity was recorded as 470.18 ± 9.75 and 978.34 ± 3.80 kg in low- and high-performance camels, respectively. Nine female Junggar Bactrian camels were subjected to transcriptome sequencing, and 609 and 393 DEGs were identified in the low-yield vs. high-yield (WDL vs. WGH) and pregnancy versus colostrum period (RSQ vs. CRQ) comparison groups, respectively. The DEGs were compared with genes associated with milk production traits in the Animal Quantitative Trait Loci database and in Alashan Bactrian camels, and 65 and 46 overlapping candidate genes were obtained, respectively. Functional enrichment and protein–protein interaction network analyses of the DEGs and candidate genes were conducted. After comparing our results with those of other livestock studies, we identified 16 signaling pathways and 27 core candidate genes associated with maternal parturition, estrogen regulation, initiation of lactation, and milk production traits. The pathways suggest that emerged milk production involves the regulation of multiple complex metabolic and cellular developmental processes in camels. Finally, the RNA sequencing results were validated using quantitative real-time PCR; the 15 selected genes exhibited consistent expression changes.ConclusionsThis study identified DEGs and metabolic pathways affecting maternal parturition and milk production traits. The results provides a theoretical foundation for further research on the molecular mechanism of genes related to milk production traits in camels. Furthermore, these findings will help improve breeding strategies to achieve the desired milk yield in camels.Graphical Abstract
Transcriptional deciphering of the metabolic pathways associated with the bioactive ingredients of wolfberry species with different quality characteristics
Authors: Liu Xuexia , Zheng Rui , Radani Yasmina , Gao Han , Yue Sijun , Fan Wenqiang , Tang Jianning , Shi Jing , Zhu Jinzhong 
Published: November 2023

Abstract
Background
Wolfberry is rich in carotenoids, flavonoids, vitamins, alkaloids, betaines and other bioactive ingredients. For over 2,000 years, wolfberry has been used in China as a medicinal and edible plant resource. Nevertheless, the content of bioactive ingredients varies by cultivars, resulting in uneven quality across wolfberry cultivars and species. To date, research has revealed little about the underlying molecular mechanism of the metabolism of flavonoids, carotenoids, and other bioactive ingredients in wolfberry.

Results
In this context, the transcriptomes of the Lycium barbarum L. cultivar ‘Ningqi No. 1’ and Lycium chinense Miller were compared during the fruit maturity stage using the Illumina NovaSeq 6000 sequencing platform, and subsequently, the changes of the gene expression profiles in two types of wolfberries were analysed. In total, 256,228,924 clean reads were obtained, and 8817 differentially expressed genes (DEGs) were identified, then assembled by Basic Local Alignment Search Tool (BLAST) similarity searches and annotated using Gene Ontology (GO), Clusters of Orthologous Groups of proteins (KOG), and the Kyoto Encyclopedia of Genes and Genomes (KEGG). By combining these transcriptome data with data from the PubMed database, 36 DEGs related to the metabolism of bioactive ingredients and implicated in the metabolic pathway of carotenoids, flavonoids, terpenoids, alkaloids, vitamins, etc., were identified. In addition, among the 9 differentially expressed transcription factors, LbAPL, LbPHL11 and LbKAN4 have raised concerns. The protein physicochemical properties, structure prediction and phylogenetic analysis indicated that LbAPL and LbPHL11 may be good candidate genes involved in regulating the flavonoid metabolism pathway in wolfberry.

Conclusions
This study provides preliminary evidence for the differences in bioactive ingredient content at the transcription level among different wolfberry species, as well as a research and theoretical basis for the screening, cloning and functional analysis of key genes involved in the metabolism of bioactive ingredients in wolfberry.
Factors associated with mechanical ventilation longer than 24 h after liver transplantation in patients at risk for bleeding
Authors: Caballero Marta , Sabate Antoni , Perez Lourdes , Vidal Julia , Reverter Enric , Gutierrez Rosa , Crespo Gonzalo , Penafiel Judith , Blasi Annabel 
Published: November 2023

Abstract
Background
This risk analysis aimed to explore all modifiable factors associated with prolonged mechanical ventilation (lasting > 24 h) after liver transplantation, based on prospectively collected data from a clinical trial.

Methods
We evaluated 306 candidates. Ninety-three patients were excluded for low risk for transfusion (preoperative haemoglobin > 130 g.l−1), and 31 patients were excluded for anticoagulation therapy, bleeding disorders, familial polyneuropathy, or emergency status. Risk factors were initially identified with a log-binomial regression model. Relative risk was then calculated and adjusted for age, sex, and disease severity (Model for End-Stage Liver Disease [MELD] score).

Results
Early tracheal extubation was performed in 149 patients (84.7%), and 27 patients (15.3%) required prolonged mechanical ventilation. Reoperations were required for 6.04% of the early extubated patients and 44% of patients who underwent prolonged ventilation (p = 0.001). A MELD score > 23 was the main risk factor for prolonged ventilation. Once modifiable risk factors were adjusted for MELD score, sex, and age, three factors were significantly associated with prolonged ventilation: tranexamic acid (p = 0.007) and red blood cell (p = 0.001) infusion and the occurrence of postreperfusion syndrome (p = 0.004). The median (IQR) ICU stay was 3 (2–4) days in the early extubation group vs. 5 (3–10) days in the prolonged ventilation group (p = 0.001). The median hospital stay was also significantly shorter after early extubation, at 14 (10–24) days, vs. 25 (14–55) days in the prolonged ventilation group (p = 0.001). Eight patients in the early-extubation group (5.52%) were readmitted to the ICU, nearly all for reoperations, with no between-group differences in ICU readmissions (prolonged ventilation group, 3.7%). Conclusion.
We conclude that bleeding and postreperfusion syndrome are the main modifiable factors associated with prolonged mechanical ventilation and length of ICU stay, suggesting that trials should explore vasopressor support strategies and other interventions prior to graft reperfusion that might prevent potential fibrinolysis.
Trial Registration.
European Clinical Trials Database (EudraCT 2018–002510-13,) and on ClinicalTrials.gov (NCT01539057).