bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer
Authors: Pinioti Sotiria , Sharma Himal , Flerin Nina C. , Yu Qian , Tzoumpa Amalia , Trusso Cafarello Sarah , De Bousser Elien , Callewaert Nico , Oldenhove Guillaume , Schlenner Susan , Thienpont Bernard , Garg Abhishek D. , Di Matteo Mario , Mazzone Massimiliano 
Published: November 2023

Abstract
Forkhead box P3 (Foxp3)–expressing regulatory T cells (Treg) are the guardians of controlled immune reactions and prevent the development of autoimmune diseases. However, in the tumor context, their increased number suppresses antitumor immune responses, indicating the importance of understanding the mechanisms behind their function and stability. Metabolic reprogramming can affect Foxp3 regulation and, therefore, Treg suppressive function and fitness. Here, we performed a metabolic CRISPR/Cas9 screen and pinpointed novel candidate positive and negative metabolic regulators of Foxp3. Among the positive regulators, we revealed that targeting the GDP-fucose transporter Slc35c1, and more broadly fucosylation (Fuco), in Tregs compromises their proliferation and suppressive function both in vitro and in vivo, leading to alteration of the tumor microenvironment and impaired tumor progression and protumoral immune responses. Pharmacologic inhibition of Fuco dampened tumor immunosuppression mostly by targeting Tregs, thus resulting in reduced tumor growth. In order to substantiate these findings in humans, tumoral Tregs from patients with colorectal cancer were clustered on the basis of the expression of Fuco-related genes. FucoLOW Tregs were found to exhibit a more immunogenic profile compared with FucoHIGH Tregs. Furthermore, an enrichment of a FucoLOW signature, mainly derived from Tregs, correlated with better prognosis and response to immune checkpoint blockade in melanoma patients. In conclusion, Slc35c1-dependent Fuco is able to regulate the suppressive function of Tregs, and measuring its expression in Tregs might pave the way towards a useful biomarker model for patients with cancer.
See related Spotlight by Silveria and DuPage, p. 1570
Measuring university size: A comparison of academic personnel versus scientific talent pool data
Authors: Lepori Benedetto , Bornmann Lutz , de Moya Anegón Félix 
Published: November 2023

Abstract
This paper compares two measures of the organizational size of higher education institutions (HEIs) widely used in the literature: the number of academic personnel (AP) measured according to definitions from international education statistics, and the scientific talent pool (STP) (i.e., the number of unique authors affiliated with the HEI as derived from the Scopus database). Based on their definitions and operationalizations, we derive expectations on the factors generating differences between these two measures, as related to the HEI’s research orientation and subject mix, as well as to the presence of a university hospital. We test these expectations on a sample of more than 1,500 HEIs in Europe by combining data from the European Tertiary Education Register and from the SCImago Institutions Ranking. Our results provide support for the expected relationships and also highlight cases where the institutional perimeter of HEIs is systematically different between the two sources. We conclude that these two indicators provide complementary measures of institutional size, one more focused on the organizational perimeter as defined by employment relationships, the other on the persons who contribute to the HEI’s scientific visibility. Comparing the two indicators is therefore likely to provide a more in-depth understanding of the HEI resources available.
The Experience of the Alien and the Inter-world: From Waldenfels to Merleau-Ponty
Authors: Stanciu Ovidiu 
Published: November 2023

Abstract
This paper aims to lay out the main tenets of Bernhard Waldenfels’s analyses of the experience of the alien and to confront the philosophical thesis underwriting them with a central insight stemming from Merleau-Ponty’s late philosophy. In the first section, I reconstruct the outlines of the experience of the alien, as described by Waldenfels, and show that, on his account, this experience can function as a powerful impetus enabling us to call into question some of the most deeply held commitments of Western philosophical tradition: the sovereignty of the ego, the supremacy of order, the priority of the whole. In the second section, I show how a patient analysis of this experience compels us to undertake an inquiry concerning the “inter-world,” understood as the place of the encounter and the threshold of separation between the own and the alien. Finally, drawing on Merleau-Ponty’s alternative description of the “inter-world,” I maintain that Waldenfels’s account is insufficiently radical and show that the in-between realm cannot be assimilated to an interstice lodged between two insulated spheres. Rather, the “inter-world” should be conceived of as a shared dimension, subtending the partition between the spheres of ownness and alienness, as the one inclusive world.
Religion, Ecology and Human Flourishing
Authors: Anthony Francis-Vincent 
Published: November 2023

Abstract
During the past six decades, there has been an ever-growing awareness of the global ecological crisis threatening human survival. Concern for the future of human life has led to the necessity of upholding environmental rights and sustainable development. As in the case of other human rights, obligations of the state that derive from these need to be complemented by civic engagements, and sustained by shared values in the societal sphere. The question that we raise is if religions can play a significant role in favouring environmental rights, civil engagements and environmental care, given that in varied ways religious traditions appeal to the interdependence of divine-human-cosmic realities. The empirical research that we undertook in the multi-religious context of Tamil Nadu, India, seeks to verify if the religious identity of the senior secondary school students and college students has some influence on their attitude towards environmental obligations, engagements and care. The results show that senior school students are highly sensitive to state’s obligations and civil engagements, but their religious affiliation does not seem to influence it. Instead, college students manifest strong agreement to environmental care, with Hindus displaying higher sensitivity. Besides, variables such as transformative function of religion, religious pluralism, human dignity, and empathy have favourable association with environmental care for Christians, Muslims and Hindus. We conclude with a discussion on the implications of the predictors for eco-education.
Transnational Mobility of Chinese Students in Portuguese-Speaking Countries: The Role of a Non-hegemonic Language
Authors: Gaspar Sofia , 马 德明 
Published: November 2023

Abstract
The idea that the acquisition of and proficiency in non-hegemonic languages can be pivotal to international student mobility has thus far been insufficiently addressed. In this paper, we draw on 23 in-depth interviews with Chinese students to explore this question, showing how the perception of Portuguese-language learning and practice at Lusophone Higher Education Institutions (e.g., in Portugal, Macao, Angola, and Brazil) represents a decisive trigger for studying abroad, and an alternative strategy for acquiring linguistic capital in a non-dominant language in which skills can be converted into competitive resources on future professional paths. We conclude by arguing for the need to address this blind spot in transnational student mobilities, and by positioning “language acquisition and proficiency” as a structuring dimension, not just of the processes by which students decide to move, but also of their imaginaries of preparedness for their future career trajectories.
Literary Mapping of Migration and Multilingualism in São Paulo’s Bom Retiro Neighborhood
Authors: Brune Krista 
Published: November 2023

Abstract
This article examines literary representations of migrant experiences in São Paulo, with a focus on the neighborhood of Bom Retiro. To study how Bom Retiro’s migrant communities of Jews, Koreans, and Bolivians demand new forms of multilingualism, I focus on the 2019 Bolivian novel Seúl, São Paulo by Gabriel Mamani Magne in comparison to Eliezer Levin’s 1972 novel Bom Retiro: o bairro da infância. Whereas Levin employs restricted multilingualism to depict a Jewish diaspora rooted in Brazil, Mamani Magne focuses on migratory flows between Bolivia and more prosperous Latin American countries. By occasionally incorporating unmarked Portuguese and Aymara words into his Spanish prose, Mamani Magne illustrates how movement between languages and places unsettles fixed forms of identity. Taken together, Bom Retiro and Seúl, São Paulo depict how multilingual gestures as part of a minor transnationalism reveal the hierarchies and misunderstandings that constitute life in the global city of São Paulo.
Monolingualism and the novel: It’s complicated…?
Authors: Gramling David 
Published: November 2023

In the first issue of the Journal of Literary Multilingualism, we collected together a range of scholars assessing and debating the field of Literary Multilingualism Studies, but we also realised that a single issue could only scratch the surface of this dynamic and growing field of study. Moreover, we were aware of some absences and blind spots and of the need to be constantly revising, questioning and examining the field. This forum, appearing in each issue of the journal, aims to continue the conversation started in Issue 1: it is a space for shorter, more informal reflections on the field and its future, in forms that might include position papers, dialogues between scholars, roundtable discussions, responses to articles within the journal, and responses to recent multilingualism conferences or events. We welcome proposals for Forum contributions, particularly from marginalised perspectives or on neglected aspects of literary multilingualism. Please contact us directly to discuss ideas.
For this first forum, we asked David Gramling, who has recently spoken about ‘breaking up’ with multilingualism, how his attitude to the field has changed in recent years, and why. We also asked him to think of the direction Literary Multilingualism Studies should take in the future, in terms of its objects, its theories, and the genres it treats.
Stop the Immigration Bill: Fighting to End Human Rights Violations and Xenophobia in Japan
Authors: Funyu Yuu 
Published: November 2023

Abstract
In March 2023, the Japanese Cabinet submitted a controversial amendment bill to the Immigration Control and Refugee Recognition Law to the ordinary Diet session. As an association working with refugees and foreign workers living in Japan, we strategically formed a protest movement against the bill both inside and outside the parliament. The parliament ignored opposition voices and approved the bill, but this result was far from the opposition’s defeat. The protest movement helped reveal multiple facts that had been concealed by Immigration and caused a drastic increase in recognition of Immigration issues in Japan.
Misunderstandings
Authors: Weizsäcker Georg 
Published: November 2023

What do we expect when we say something to someone, and what do they expect when they hear it? When is a conversation successful? The book considers a wide set of two-person conversations, and a bit of game theory, to show how conversational statements and their interpretations are governed by beliefs. Thinking about beliefs is suitable for communication analysis because beliefs are well-defined and measurable, allowing to differentiate between successful understandings and their less successful counterparts: misunderstandings.
The book describes the theoretical framework and empirical measurements of misunderstandings – written by an economist, but in simple words and using interdisciplinary concepts. The material will benefit students and researchers of behavioural economics and its neighbouring fields, and anyone interested in human language.
An Increase in the Antarctic Surface Mass Balance during the Past Three Centuries, Dampening Global Sea Level Rise
Authors: Wang Yetang , Xiao Cunde 
Published: November 2023

Abstract
Antarctic surface mass balance (SMB) is a direct regulator of global sea level changes, but quantification of its long-term evolution at the ice sheet scale is challenging. Here, we combine for the first time a recently complied dataset of ice core records with the outputs of five different reanalysis products and two regional climate models to produce a reconciled 310-yr reconstruction of spatially and temporally complete SMB over the Antarctic Ice Sheet (AIS). Despite greatly variable signs and magnitudes of reconstructed SMB trends in the different regions, a significant positive trend (3.6 ± 0.8 Gt yr−1 decade−1) is observed for SMB over the entire AIS during the past 300 years, with a larger increase rate since 1801. The increased SMB cumulatively dampened global sea level rise by ∼14 mm between 1901 and 2010, which did not account for the ice sheet dynamical imbalance. The first and second modes of empirical orthogonal function analysis (EOF1 and EOF2) capture 38.0% and 24.6% of the total variability in reconstructed SMB, respectively. EOF1 consists of an east–west dipole of SMB changes over West Antarctica, primarily driven by Southern Annular Mode (SAM) variability. EOF2 represents a strong signal over the whole Antarctic Peninsula and coastal West Antarctica, which is not associated with SAM, but with El Niño–Southern Oscillation (ENSO) at the decadal scale.
An Examination of the Association between Emotion Regulation and Emetophobia Symptoms
Authors: Petell Jennifer A. , Bilsky Sarah A. 
Published: November 2023

Background Specific phobia of vomiting, referred to as emetophobia, is a specific phobia characterized by persistent and severe fear of vomit. Individuals with emetophobia engage in a variety of emotional and behavioral avoidance strategies to distance themselves from perceived vomit-related threat. As such, individuals may struggle to effectively use emotion regulation (ER) skills; however, to date, limited work has examined the association between emotion regulation and emetophobia symptoms. The present study aimed to address this gap in the literature and examine the association between ER and emetophobia symptoms. Methods Participants ( N = 508) were a remote, clinical sample of individuals recruited via social media forums dedicated to the disorder who self-identified as experiencing emetophobia. Hierarchical linear regressions were used to assessed unique contributions of ER to emetophobia symptoms. Age, gender, and depressive symptoms were entered as covariates in the hierarchical regression. Results Results demonstrated ER was significantly related to emetophobia symptoms above and beyond the effects of depressive symptoms, age and gender in the current sample. Conclusions The findings provide initial support for an association between ER and emetophobia, and suggest future directions for refining the conceptualization of emetophobia. Limitations and considerations include the recruitment strategy via social media websites for individuals with emetophobia, limited diversity of the sample, and cross-sectional nature.
Clonidine safety and effectiveness in the management of suspected paroxysmal sympathetic hyperactivity post-traumatic brain injury: A retrospective cohort study
Authors: Alshaya Abdulrahman I , Aldhaeefi Mohammed , Alodhaiyan Nada , Alqahtani Maha , Althewaibi Sarah , Alshahrani Wala , Al Sulaiman Khalid , Al Harbi Shmeylan A. , Vishwakarma Ramesh , Aldabbagh Tariq 
Published: November 2023

Introduction: Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. In addition, TBI may cause paroxysmal sympathetic hyperactivity (PSH), which is associated with poor clinical outcomes. This study aimed to evaluate the safety and effectiveness of clonidine in patients with TBI and suspected PSH. Methods: A retrospective cohort study for critically ill patients with TBI with suspected PSH admitted to intensive care units (ICUs) from 1 May 2016 to 31 January 2020 at a tertiary academic medical center. Eligible patients were categorized based on clonidine use during their ICU stay (Clonidine group vs. Control group). The primary outcome was the improvement in functional outcomes during ICU stay, defined by a delta Glasgow Coma Score (GCS). Secondary outcomes included ICU and hospital length of stay, heart rate variation, and 90-day mortality. Results: A total of 2915 patients were screened, of which 169 were included. Based on multiple regression analysis, patients who received clonidine showed better improvement in functional outcomes by a higher mean delta GCS than patients who did not (Beta Coeff. 0.41; CI: 0.07 – 0.74; P = 0.02). In addition, the patient's GCS upon ICU discharge and IV opioids requirement on day three were higher in the clonidine group than control (beta coefficient (95% CI): 0.18 (0.03, 0.32); p = 0.02 and beta coefficient (95% CI): 1.38 (0.24, 2.52); p = 0.02, respectively). No statistical differences were observed in any of the other secondary outcomes after adjusting for confounders. Conclusion: This study found that patients who received clonidine had better functional outcomes during their ICU stay, as shown by their delta GCS than those who did not. Other outcomes were similar between the groups. More data are needed to explore the role of clonidine in patients with TBI with suspected PSH.
Using Debriefing as a Tool to Enhance the Educational Value of Undergraduate Research Participation
Authors: Flynn Maureen K. , Bordieri Michael J. 
Published: November 2023

Background Limited research exists on enhancing the educational value of research participation among undergraduate research participants. Objective The aim of the current studies was to examine the impact of extended debriefings and incentives on actual learning and perceptions of research participation. Method Three undergraduate samples were recruited from introductory psychology courses. A total of 943 students participated across the three studies by completing a series of assessments online. Results Findings from this series of studies suggest that extended video debriefings, especially when combined with instructions that incentivize attending to debriefing content, may be an effective tool to increase the educational value of undergraduate research participation. Conclusion Extended debriefings and incentives may enhance learning associated with research participation among undergraduates. Teaching Implications Psychology departments could consider using extended debriefings and incentives to enhance learning and quizzes to assess learning outcomes associated with research participation.
A prospective feasibility trial exploring novel biomarkers for neurotoxicity after isolated limb perfusion
Authors: Corderfeldt Keiller Anna , Axelsson Markus , Bragadottir Gudrun , Blennow Kaj , Zetterberg Henrik , Olofsson Bagge Roger 
Published: November 2023

Background Isolated limb perfusion (ILP) is a regional cancer treatment in which high-dose chemotherapy is administered in an isolated extremity. The main side effect is regional toxicity, which occasionally leads to nerve damage. Measuring neuroaxonal biomarkers, might be a method predicting such complications. Therefore, the primary aim of the study is to investigate if neuronal biomarkers are measurable and alters in an isolated extremity during ILP. Secondly, if postoperative regional toxicity, alterations in sensitivity, and/or muscle strength are correlated to the biomarker levels. Methods Eighteen scheduled ILP-patients were included in the study. Glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and tau concentrations were measured in plasma sampled preoperatively, at the start and end of the ILP, on days 3 and 30, using ultrasensitive Single molecule array (Simoa) technology. The patients were assessed by a physiotherapist pre- and postoperatively. Results At ILP end, significantly higher NfL and tau levels were measured in the extremity than in the corresponding systemic circulation (NfL; 17 vs 6 ng/L, p < .01, tau; 1.8 vs 0.6 ng/L, p < .01), and the extremity levels were significantly increased at ILP end (NfL; 66 ± 37%, p < .001, tau; 75 ± 45%, p = .001). On days 3 and 30, significantly increased NfL and GFAP levels were measured systemically (NfL day 3: 69 ± 30%, p < .001; day 30: 76 ± 26%, p < .001; GFAP day 3: 33 ± 22%, p < .002; day 30: 33 ± 23%, p ≤ .004). Finally, no significant correlations were found between regional toxicity or between postoperative muscle or sensitivity decrease and biomarker release. Conclusion During ILP, NfL and tau levels increased significantly. No obvious correlations were observed between biomarker release and regional toxicity or decreased muscle strength or sensitivity, although large-scale studies are warranted.
Prevalence of LUTS in young female population attending tertiary care centre
Authors: Negi Saurabh Kumar , Vyas Nachiket , Desai Sandip , Faujdar Gaurav , Priyadarshi Shivam 
Published: November 2023

Objective: To obtain the prevalence of lower urinary tract symptoms (LUTS) in young female population in tertiary care centre. Method: We conducted a descriptive and analytic study with ques tionnaire based data collection. All subjects were interviewed using conventional method and International Consultation on Incontinence Questionnaire (ICIQ) Female LUTS form in the urology outpatient department, SMS medical college and hospital, Jaipur (India). Result: Total 1278 patients enrolled in study. Using the well-structured questionnaire using ICIQ-FLUTS form, the prevalence of LUTS was 78.01% while conventional method having only 35.8%. This result revealed that LUTS is a common condition among young Indian female population with vaginal delivery as the common risk factor. Conclusion: Screening for LUTS using a structured questionnaire identified a significantly higher prevalence of LUTS than the conventional method. The ICIQ-FLUTS form is a robust questionnaire that can be recommended for use in epidemiological research as well as routine clinical practice.
Camposampiero tubeless percutaneous nephrolithotomy (tPCNL): Easy, quick, effective, safe
Authors: De Gobbi Alberto , Lupi Amalia , Massari Domenico , Stellato Alberto , Behr Astrid Ursula , Costa Giuseppe , Fiorello Mario 
Published: November 2023

Objectives: To describe our technique to perform tubeless percutaneous nephrolithotomy (tPCNL) using hemostatic matrix (i.e. Floseal®) for the closure of the percutaneous tract, developed through the experience gained in our endourology specialized center. To evaluate the procedure efficacy and safety. Methods: tPCNL performed in our center with Floseal® application from February 2017 to December 2019 were retrospectively reviewed. Clinical and surgical data were collected in order to evaluate the success of the procedure and possible complications. Camposampiero technique is reported in detail. Results: Sixty-nine patients (45 males, mean age 58 years old) were included. In all patients the procedure was completed successfully and in 88% of subjects no further treatments were necessary; a low complication rate (6.9%) was reported. Conclusion: In our experience, tPCNL with Floseal application is feasible, safe, and effective.