bluuebunny/crossref_metadata_2025_split huggingface dataset:
The der(1;7)(q10;p10) defining a distinct profile from −7/del(7q) in myelodysplastic syndromes: A systematic review and meta‐analysis
Authors: Lang Wei , Luo Yingwan , Wang Lu , Zhang Yudi , Hu Chao , Wang Huanping , Tong Hongyan 
Published: January 2024

AbstractBackground and ObjectiveMyelodysplastic syndromes (MDS) are myeloid neoplasms characterized by ineffective hematopoiesis due to stem cell abnormalities. Monosomy 7q aberrations are a common cytogenetic abnormality in MDS. Specifically, an unbalanced translocation der(1;7)(q10;p10) [der(1;7)] has been identified in MDS patients, which is a monosomy 7q aberration variant like −7/del(7q). However, knowledge of der(1;7)'s features remains limited. Existing studies have compared the clinical and genetic characteristics of der(1;7) to those of −7/del(7q) but yielded inconsistent findings. Accordingly, we conducted meta‐analyses comparing der(1;7) to −7/del(7q).MethodsPublications were searched from the following databases up to January 10, 2023: Pubmed, Web of Science, Embase, Cochrane, and ClinicalTrials.gov. Eligible studies were assessed for risks of bias. Relevant data were extracted from included studies and analyzed using random‐effects models. Publication bias was evaluated and sensitivity analyses were performed.ResultsThe comparative meta‐analyses included 405 MDS patients with der(1;7) from nine studies. The analysis revealed that der(1;7) was associated with a greater male preponderance (86.1% vs. 68.3%, Odds Ratios (ORs) 2.007, p < 0.01) than −7/del(7q), lower platelets counts compared to del(7q), higher hemoglobin levels than −7, lower absolute neutrophil counts, and higher percentage of patients with non‐excess blasts (66.9% vs. 41.3%, ORs 2.374, p = 0.01) in comparison with −7/del(7q). The der(1;7) existed more as a sole karyotype aberration (55.6% vs. 37.0%, ORs 2.902, p = 0.02), co‐occurred more often with +8 (22.7% vs. 4.2%, ORs 5.714, p = 0.04) whereas less −5/del(5q) (1.5% vs. 41.3%, ORs 0.040, p < 0.01) and complex karyotype (7.3% vs. 54.8%, OR 0.085, p < 0.01). The der(1;7) was associated with higher frequencies of RUNX1 (40.8% vs. 12.3%, ORs 4.764, p < 0.01), ETNK1 (28.1% vs. 2.5%, ORs 42.106, p < 0.01) and EZH2 (24.8% vs. 6.9%, ORs 3.767, p = 0.02) mutations, but less TP53 mutation (2.4% vs. 45.3%, ORs 0.043, p < 0.01). Moreover, der(1;7) patients had longer time to progression (Hazard Ratios (HRs) 0.331, p = 0.02), better overall survival (OS) than −7 patients (HRs 0.557, p < 0.01), but similar OS with del(7q) patients (HRs 0.837, p = 0.37).ConclusionThe findings revealed distinct clinical, cytogenetic, and molecular characteristics distinguishing der(1;7) from −7/del(7q), indicating der(1;7) defines a unique subtype within MDS with monosomy 7q. These findings support classifying der(1;7) as a separate MDS entity in future.
Intensified conditioning regimens with total marrow irradiation/etoposide/cyclophosphamide and busulfan/etoposide/cyclophosphamide overcome the impact of pre‐transplant minimal residual disease on outcomes in high‐risk acute lymphoblastic leukemia patients in complete remission
Authors: Zhao Xiaoyan , Xu Ziwei , Li Ziying , Zhou Xi , Hu Yu , Wang Huafang 
Published: January 2024

AbstractPurposeAmong high‐risk acute lymphoblastic leukemia (ALL) patients undergoing allogeneic hematopoietic stem cell transplantation (allo‐HSCT), those with positive minimal residual disease (MRD) are susceptible to poor outcomes. Therefore, it is necessary to determine the most suitable preparatory regimen for these patients.MethodsData were analyzed from 141 patients who received allo‐HSCT and were diagnosed with high‐risk ALL. These patients underwent intensified conditioning regimens, including either total marrow and lymphoid irradiation (TMLI)‐etoposide (VP16)‐cyclophosphamide (CY) or busulfan (BU)‐VP16‐CY between October 2016 and November 2022. A total of 141 individuals were in complete remission (CR) before transplantation and, among all patients, 90 individuals exhibited a negative MRD status and 51 patients had a positive MRD status.ResultsIn patients who tested negative for MRD, the incidence of relapse within a 2‐year timeframe was 25.0% (24.8%–25.5%), compared with 32.2% (31.2%–33.2%) in MRD‐positive patients; however, this difference was not statistically significant. There were no significant differences in the 2‐year disease‐free survival (DFS) and 2‐year overall survival (OS) rates between the MRD‐negative and MRD‐positive groups (DFS: 67.2% (57.9%–78.1%) vs. 55.5% (42.6%–72.3%); OS: 69.0% (61.9%–88.2%) vs. 66.7% (53.9%–82.5%)). Furthermore, no notable variations were observed in the occurrence of transplant‐related mortality (TRM) and graft‐versus‐host disease (GVHD) across the two groups.ConclusionThis study reveals the benefits of TMLI‐VP16‐CY and BU‐VP16‐CY conditioning regimens in high‐risk ALL patients with CR and MRD‐positive status. A large‐scale prospective clinical trial is warranted in the future.
Folic Acid‐Conjugated Chitosan‐Coated Solid Lipid Nanoparticles: Precision Targeting of Artemisia vulgaris Essential Oils for Anticancer Therapy
Authors: Aghabagherzadeh Mozhdeh , Karimi Ehsan , Zareian Mohsen 
Published: January 2024

AbstractIn this study, we developed Solid Lipid Nanoparticles (SLN‐NPs) loaded with Artemisia vulgaris essential oil and coated with folic acid‐chitosan (AVEO‐SCF‐NPs) to enhance drug delivery in biotechnology and pharmaceutical sectors. AVEO‐SCF‐NPs were synthesized using homogenization and ultra‐sonication methods and comprehensively characterized. These nanoparticles exhibited a particle size of 253.67 nm, Polydispersity Index (PDI) of 0.26, zeta potential (ζ‐p) of +39.96 mV, encapsulation efficiency (%EE) of 99.0 %, and folic acid binding efficiency (% FB) of 46.25 %. They effectively inhibited MCF‐7, HT‐29, and PC‐3 cancer cells with IC50 values of 48.87 μg/mL, 88.48 μg/mL, and 121.34 μg/mL, respectively, and demonstrated antibacterial properties against Gram‐positive strains. AVEO‐SCF‐NPs also exhibited scavenging effects on ABTS (IC50: 203.83 μg/mL) and DPPH (IC50: 680.86 μg/mL) free radicals and inhibited angiogenesis, as confirmed through CAM and qPCR assays. Furthermore, these nanoparticles induced apoptosis, evidenced by up‐regulation of caspase 3 and 9, down‐regulation of TNF‐α genes, and an increase in SubG1 phase cells. The high loading capacity of SCF‐NPs for AVEO, coupled with their multifaceted biological properties, highlights AVEO‐SCF‐NPs as promising candidates for cancer therapy in the biotechnology and pharmaceutical industries.
Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L‐arginine
Authors: Ginovyan Mikayel , Javrushyan Hayarpi , Karapetyan Hasmik , Koss‐Mikołajczyk Izabela , Kusznierewicz Barbara , Grigoryan Anna , Maloyan Alina , Bartoszek Agnieszka , Avtandilyan Nikolay 
Published: January 2024

AbstractConventional treatment methods are not effective enough to fight the rapid increase in cancer cases. The interest is increasing in the investigation of herbal sources for the development of new anticancer therapeutics. This study aims to investigate the antitumor capacity of Hypericum alpestre (H. alpestre) extract in vitro and in vivo, either alone or in combination with the inhibitors of the
l‐arginine/polyamine/nitric oxide (NO) pathway, and to characterize its active phytochemicals using advanced chromatographic techniques. Our previous reports suggest beneficial effects of the arginase inhibitor NG‐hydroxy‐nor‐
l‐arginine and NO inhibitor NG‐nitro‐Larginine methyl ester in the treatment of breast cancer via downregulation of polyamine and NO synthesis. Here, the antitumor properties of H. alpestre and its combinations were explored in vivo, in a rat model of mammary gland carcinogenesis induced by subcutaneous injection of 7,12‐dimethylbenz[a]anthracene. The study revealed strong antiradical activity of H. alpestre aerial part extract in chemical (DPPH/ABTS) tests. In the in vitro antioxidant activity test, the H. alpestre extract demonstrated pro‐oxidant characteristics in human colorectal (HT29) cells, which were contingent upon the hemostatic condition of the cells. The H. alpestre extract expressed a cytotoxic effect on HT29 and breast cancer (MCF‐7) cells measured by the MTT test. According to comet assay results, H. alpestre extract did not exhibit genotoxic activity nor possessed antigenotoxic properties in HT29 cells. Overall, 233 substances have been identified and annotated in H. alpestre extract using the LC‐Q‐Orbitrap HRMS system. In vivo experiments using rat breast cancer models revealed that the H. alpestre extract activated the antioxidant enzymes in the liver, brain, and tumors. H. alpestre combined with chemotherapeutic agents attenuated cancer‐like histological alterations and showed significant reductions in tumor blood vessel area. Thus, either alone or in combination with Nω‐OH‐nor‐
l‐arginine and Nω‐nitro‐
l‐arginine methyl ester, H. alpestre extract exhibits pro‐ and antioxidant, antiangiogenic, and cytotoxic effects.
N6 methyladenosine eraser FTO suppresses Staphylococcus aureus‐induced ferroptosis of bone marrow mesenchymal stem cells to ameliorate osteomyelitis through regulating the MDM2/TLR4/SLC7A11 signaling pathway
Authors: Song Muguo , Lv Kehan , Xu Zhi , Li Junyi , Sun Jian , Shi Jian , Xu Yongqing 
Published: January 2024

AbstractOsteomyelitis is a bone destructive inflammatory disease caused by infection. Ferroptosis is closely related to multiple inflammatory diseases, but the role of ferroptosis in Staphylococcus aureus (SA)‐induced osteomyelitis remains unknown. In the present study, we found that SA treatment promoted the accumulation of iron, Fe2+, lipid peroxide, and malondialdehyde, increased TFRC and reduced FTH1 and GPX4 to trigger ferroptosis in rat bone marrow mesenchymal stem cells (BMSCs). Interestingly, increased level of N6 methyl adenosine (m6A) modification along with decreased expression level of m6A eraser FTO were observed in SA‐induced BMSCs, while upregulating FTO alleviated SA‐triggered ferroptosis and protected cell viability in BMSCs. Mechanistically, MDM2 was identified as a target of FTO‐mediated m6A demethylation, and FTO upregulation promoted MDM2 instability to downregulated TLR4 signal and elevate the expression of SLC7A11 and GPX4 in SA‐induced BMSCs. Functional recovery experiments verified that overexpressing MDM2 or TLR4 reversed the inhibiting effect of FTO upregulation on ferroptosis in SA‐treated BMSCs. Additionally, FTO upregulation restrained ferroptosis and pathological damage to bone tissue in SA‐induced osteomyelitis model rats. Altogether, m6A eraser FTO alleviates SA‐induced ferroptosis in osteomyelitis models partly through inhibiting the MDM2‐TLR4 axis.
The carrier effect of ternary solid solution derived by trimetallic CeZrNi MOFs on the Pd dispersion stability for NGVs exhaust purification
Authors: Yang Jiahao , Yue Xinyu , Liao Wannian , Wei Xiaxia , Ruan Le , Tang Fushun 
Published: January 2024

AbstractThis article was the first to prepare CeZrNiOx ternary solid solution using CeZrNi BDC MOFs as a template, and investigate its effect on improving the dispersion stability of Pd components in three‐way catalysts and the catalytic performance of natural gas exhaust purification. The experimental results indicated that CeZrNiOx derived from CeZrNi‐BDC MOFs had a stable solid solution uniform structure and relatively good thermal stability of the porous structure. Therefore, the thermal stability of Pd/CZN−M derived from CeZrNi BDC MOFs was significantly better than that of Pd/CZN−C prepared by citric acid complexation method. The PdO particle size of Pd/CZN−M before and after thermal aging was only about 2.0 and 4.5 nm, respectively. At GHSV50000 ml/(g⋅h), the T90 of aged Pd/CeZrNiOx for CH4, NO, and CO reached 410, 370, and 175 °C, respectively, showing better three‐way catalytic (TWC) activity than reported in existing literature. In addition, CeZeNiOx carriers derived from MOFs also enhanced the co‐activation ability of NO and CH4, and exhibited certain activity in the low‐temperature self‐decomposition reaction of NO, thus showing significant advantages in the TWC catalytic activity of NGVs. This work would provide a new method for preparing NGVs exhaust TWC catalysts with high dispersion stability.
Elevating Lithium‐Sulfur Battery Durability through Samarium Oxide/Ketjen Black Modified Separator
Authors: Zheng Liyuan , Zhu Zhijun , Kuai Yutong , Chen Guihuan , Yu Zhihong , Wang Yi , Li Aiju 
Published: January 2024

AbstractLithium‐sulfur batteries have garnered significant attention as a promising next‐generation battery technology due to their potential for high energy density. However, their practical application is hampered by slow reaction kinetics and the shuttle effect of lithium polysulfide intermediates. In this context, the authors introduce a pioneering solution in the form of a novel porous carbon nanostructure modified with samarium oxide, denoted as Sm2O3/KB. The material has a highly polar surface, allowing lithium polysulfide to be chemisorbed efficiently. The unsaturated sites provided by the oxygen vacancies of Sm2O3 promote Li2S nucleation, lowering the reaction energy barrier and accelerating Li2S dissolution. The porous structure of Ketjen Black provides a highly conductive channel for electron transport and effectively traps polysulfides. Meanwhile, the batteries with Sm2O3/KB/PP spacers exhibited remarkable electrochemical performances, including a low‐capacity decay rate of only 0.046 % for 1000 cycles at 2 C and an excellent multiplicative performance of 624 mAh g−1 at 3 C. This work opens up a new avenue for the potential use of rare‐earth‐based materials in lithium‐sulfur batteries.
Polyoxometalate‐dependent Photocatalytic Activity of Radical‐doped Perylenediimide‐based Hybrid Materials
Authors: Dai Weijun , Li Xiaobo , He Chixian , Li Xiang , Kong Ci , Cheng Feixiang , Liu Jian‐Jun 
Published: January 2024

AbstractInorganic‐organic hybrid materials are a kind of multiduty materials with high crystallinity and definite structures, built from functional inorganic and organic components with highly tunable photochemical properties. Perylenediimides (PDIs) are a kind of strong visible light‐absorbing organic dyes with π‐electron‐deficient planes and photochemical properties depending on their micro‐environment, which provides a platform for designing tunable and efficient hybrid photocatalytic materials. Herein, four radical‐doped PDI‐based crystalline hybrid materials, Cl4‐PDI⋅SiW12O40 (1), Cl4‐PDI⋅SiMo12O40 (2), Cl4‐PDI⋅PW12O40 (3), and Cl4‐PDI⋅PMo12O40 (4), were attained by slow diffusion of polyoxometalates (POMs) into acidified Cl4‐PDI solutions. The obtained PDI‐based crystalline hybrid materials not only exhibited prominent photochromism, but also possessed reactive organic radicals under ambient conditions. Furthermore, all hybrid materials could be easily photoreduced to their radical anions (Cl4‐PDI⋅−), and then underwent a second photoexcitation to form energetic excited state radical anions (Cl4‐PDI⋅−*). However, experiments and theoretical calculations demonstrated that the formed energetic Cl4‐PDI⋅−* showed unusual POM‐dependent photocatalytic efficiencies toward the oxidative coupling of amines and the iodoperfluoroalkylation of alkenes; higher photocatalytic efficiencies were found for hybrid materials 1 (anion: SiW12O404−) and 2 (anion: SiMo12O404−) compared to 3 (anion: PW12O403−) and 4 (anion: PMo12O403−). The photocatalytic efficiencies of these hybrid materials are mainly controlled by the energy differences between the SOMO‐2 level of Cl4‐PDI⋅−* and the LUMO level of the POMs. The structure‐photocatalytic activity relationships established in present work provide new research directions to both the photocatalysis and hybrid material fields, and will promote the integration of these areas to explore new materials with interesting properties.
In Continuo Pd‐Catalysed Cross Coupling Reactions of Organolithium Reagents with Aryl Bromides Under Aerobic Conditions
Authors: Brucoli Jacopo , Gariboldi Davide , Puglisi Alessandra , Rossi Sergio , Capriati Vito , Benaglia Maurizio 
Published: January 2024

AbstractTransition metal‐catalysed C−C couplings are widely used to synthesize organic molecules. In this area, the direct use of readily available and relatively inexpensive organolithium reagents in Pd cross‐coupling reactions represents an attractive option, but its large‐scale application remains a formidable challenge. The high reactivity of organolithium reagents, along with the need (sometimes) of tailored, expensive catalysts and long reaction times, often prevent these procedures from being applied to industry. However, continuous flow technologies recently emerged as a powerful tool in discovery and process chemistry, and may offer a solution to overcome the above issues. Here, we wish to report fast, efficient, in continuo Pd‐catalysed cross coupling reactions of organolithium reagents with aryl bromides, under aerobic conditions, that do not require an inert atmosphere, with a catalyst loading that has been lowered up to 0.5 % mol. The methodology has a wide scope and has been successfully applied to the synthesis in flow of a novel class of anti‐cancer compounds.
The development process of a candidate screening test for cladding products
Authors: MacLeod Cameron , Butterworth Neal , Law Angus 
Published: January 2024

AbstractThe ongoing cladding crisis within the United Kingdom has elevated the need for designers and risk assessors to have the knowledge and tools to evaluate the fire safety of proposed and existing cladding systems. This paper documents efforts to develop a test that could be used to evaluate the fire safety hazards of cladding products that were either proposed for use in design or that were found on existing buildings. Specifically, the products of interest were composite products (i.e., those comprised of multiple layers). The conceptual approach of the European harmonised system was used as a basis for investigating whether a small‐scale test could be used to evaluate product fire hazards. A relevant fire scenario was identified, this was linked to candidate large‐scale reference tests, and this was linked to performance in a candidate small‐scale test. The candidate test showed remarkable agreement with the reference large‐scale test, however, many issues were also identified. It was found that, even when specifically intended to accommodate composite products, the small‐scale test was unable to always evaluate hazards. Thus the authors were left with the conclusion—regardless of the testing system, there are always products that will not fit the testing system, however hard one tries.
Characteristics and antioxidant activities of seed oil from okra (Abelmoschus esculentus L.)
Authors: Guo Gangjun , Xu Wenting , Zhang Haiqing , Hu Xiaojing , Chen Yuqin , He Xiyong , Huang Kechang , Ma Shangxuan , Fu Jiarong 
Published: January 2024

AbstractTo investigate the potential functional properties and added value of okra seed oil and provide a scientific basis for further industrial development and production of okra seed oil, its fatty acid profile, total phenolic, fat‐soluble vitamin composition, mineral element composition, and antioxidant activities were examined in this study. Also, correlations between bioactive components and the antioxidant activities of okra seed oil were explored. The study results show that okra seed oil contains 12 types of fatty acids, 65.22% of which are unsaturated acids, and among these unsaturated acids, linoleic acid (43%) and oleic acid (20.16%) are two dominant acid types. Compared with walnut oil and peanut oil, okra seed oil contains relatively high total phenols, fat‐soluble vitamins, and a variety of essential mineral nutrients, with a total phenolic content (TPC) of 959.65 μg/mL, a total tocopherol content of 742.71 μg/mL, a vitamin A content of 0.0017 μg/100 mL, a vitamin D content of 1.44 μg/100 mL, and a vitamin K1 content of 52.54 ng/100 mg. Also, okra seed oil exhibits better scavenging activities on hydroxyl (IC50 = 0.50 mg/mL) and ammonium salt (ABTS) free radicals (IC50 = 6.46 mg/mL) and certain reducing power (IC50 = 17.22 mg/mL) at the same concentration. The scavenging activities of okra seed oil on hydroxyl radicals and ABTS radicals, as well as its reducing power, are significantly correlated with its contents of total phenol, total tocopherol, α‐tocopherol, and γ‐tocopherol (p < .01). These results show that okra seed oil is rich in bioactive substances, thus presenting great nutritional potential.
Sand rice, a promising future crop for desert and marginal lands in northern China
Authors: Zhao Pengshan , Ran Ruilan , Sun Hong , Liu Yujie , Li Xiaofeng , Wang Changbao , Zhao Xin , Chen Guoxiong 
Published: January 2024

AbstractThe pioneer Amaranthaceae species sand rice (Agriophyllum squarrosum) is an annual psammophyte that is widely distributed in the deserts and sand fields of northern China. The well‐balanced nutritional values, long consumption history, and extreme stress tolerance of sand rice have fascinated scientists, prompting its development as a climate‐resilient crop. Sand rice has been successfully introduced and cultivated on sandy and loess lands over the past decade, while large‐scale artificial planting has been carried out in the Ulan Buh and Tengger deserts. However, the yield is far below the maximum potential, as estimated by the highest yield per plant ever found in the Tengger desert during our survey of wild populations. The current domestication of sand rice relies mainly on natural selection and mutagenesis breeding. A few elite lines with modified agronomic traits, such as compact architecture, high productivity, reduced trichomes, and short plant stature, have been developed from natural populations and a chemical mutagenesis library. Breeding new cultivars and broader cultivation of sand rice in deserts and marginal lands will stimulate economic growth and diversify the food supply, especially for the area west of the Hu Huanyong Line, thus contributing to environmental sustainability in northern China.
Novel intertypic recombination of Echovirus 11 in the Enterovirus species B
Authors: Gong Yu‐Nong , Yang Shu‐Li , Chen Yi‐Ching , Liu Yi‐Chun , Huang Yhu‐Chering , Tsao Kuo‐Chien 
Published: January 2024

AbstractEnteroviruses (EVs), single‐stranded, positive‐sense RNA viruses, can be classified into four species (A−D), which have previously been linked to a diverse range of disease manifestations and infections affecting the central nervous system. In the Enterovirus species B (EV‐B), Echovirus type 11 (E11) has been observed to occasionally circulate in Taiwan, which was responsible for an epidemic of enterovirus infections in 2018. Here, 48 clinical specimens isolated in 2003, 2004, 2009, and 2018 were collected for the high‐throughput sequencing. Notably, we identified 2018 Taiwanese strains having potential recombinations in the 3D gene, as well as one 2003 strain having a double recombination with E6 and Coxsackievirus B5 in the P2 and P3 regions, respectively. Additionally, one amino acid signature mutated from the Histidine (H) in throat swab specimens to the Tyrosine (Y) in cerebral spinal fluid specimens was detected at position 1496 (or 57) of the genomic coordinate (or 3A gene) to further demonstrate intra‐host evolution in different organs. In conclusion, this study identifies potential intertypic recombination events and an intra‐host signature mutation in E11 strains, isolated during a 2018 neurological disease outbreak in Taiwan, contributing to our understanding of its evolution and pathogenesis.