bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis of Regional Socioeconomic Heterogeneous Indicators in the Subjects of the Arctic Zone of the Russian Federation and Their Integral Assessment
Authors: Bose Upasak , Gennadevna Kuzmenko Yulia , Markovich Greiz Georgy 
Published: January 2024

The Arctic Zone of Russian Federation (AZRF) is a unique geography with diverse socioeconomic factors playing significant roles in its stability and progress. In order to accurately assess and evaluate the overall socioeconomic progress of AZRF, the heterogeneous factors should be considered in an integrated manner, which will give a holistic view of the socioeconomic stability and development of the region. The available literature on socioeconomic development of Russian Arctic region however suffers from lack of integrated analysis of heterogeneous indicators. In this article, the authors have selected five heterogeneous indicators which best describe the socioeconomic condition of a given region, which in this case is AZRF and performed integral analysis for the time period 2014–2019. The indicators refer to socioeconomic aspects such as gross regional product and amount of investments received by the region, which in turn leads to changes in employment opportunities and income level of the population along with social benefits available to them. The mathematical instrument used for the analysis is the theory of fuzzy logic in the framework of determination of the subdirect image of a fuzzy set. This method is scalable and can be extended to any number of indicators of diverse nature since the final score will be in the range of [0, 1] making comparison of regions and ranking possible. Using this method, the subjects were ranked at individual indicator level and at holistic level as a result of which the advantages and disadvantages of each subject and the AZRF as a whole were determined. At holistic level, the subjects were ranked as Krasnayarsky Krai, Arkhangelsk Oblast, Republic of Komi, Murmansk Oblast, Yamalo-Nenets Autonomous Okrug, Karelia Republic, Sakha Republic (Yakutia), Nenets Autonomous Okrug and Chukotka Autonomous Okrug based on the integral scores obtained. JEL Code: R11
Former smoking as a risk factor for visual field progression in exfoliation glaucoma patients in Sweden
Authors: Ayala Marcelo 
Published: January 2024

Purpose The present study aimed to identify whether former smoking was a risk factor for visual field progression in exfoliation glaucoma patients. Methods Prospective nonrandomised cohort study. The study included patients diagnosed with exfoliation glaucoma. All included patients were followed for three years (± three months) with reliable visual fields. At least five reliable visual fields needed to be included in the study. Exfoliation glaucoma was defined using the European Glaucoma Society Guidelines. The visual fields were tested using the 24–2 test strategy of the Humphrey Field Analyzer. Smoking was assessed through questionnaires. Outcomes: Visual field progression. Three different approaches were used: difference in mean deviation (MD), rate of progression (ROP), and guided progression analysis (GPA). Results In total, n = 113 patients were included; among them, n = 57 were smokers. Smoking was a significant predictor for visual field progression in the three models (MD/ROP/GPA) studied ( p = 0.01/ p = 0.001/p ≤ 0.001), even adjusting for intraocular pressure (IOP). Other predictors were included in the MD model: IOP at diagnosis ( p = 0.04) and selective laser trabeculoplasty (SLT) treatment ( p = 0.01). Other predictors were in the ROP model: Visual field index ( p = 0.005), number of medications ( p = 0.001) and SLT treatment ( p = 0.001). The number of medications was another predictor in the GPA model ( p = 0.002). Conclusions Former smoking induced visual field deterioration in all models studied. Smoking status should be considered when establishing the glaucoma diagnosis. Increased glaucoma care should be provided to former smokers to slow the progression of the disease.
Analysis of the strength of joints in fabric/ unsaturated polyester composites
Authors: El Messiry Magdi , El-Tarfawy Shaimaa , El Deeb Rania 
Published: January 2024

Fabric/unsaturated polyester composites have garnered significant attention due to their lightweight properties and superior mechanical characteristics. Despite these advantages, the strength of joints within these composites remains a crucial aspect requiring thorough investigation. This paper presents a study focused on comprehending the factors that influence joint strength in fabric/polymer composites, emphasizing the importance of effective load transfer and robust adhesion within the fabric/polymer matrix. The objective is to minimize stress concentration and enhance load distribution within the joint. The failure mechanism involves a combination of Bearing Failure and shear-out failure, particularly in single-fabric layer composites. The study establishes a linear relationship between composite bending stiffness and the enforcement fabric’s flexural rigidity. A comparison of tensile properties across various joining methods, such as bolts, adhesive bonding, and tongue grooves, reveals that bolt joints exhibit the highest strength and elongation, followed by tongue groove joints. Notably, bolt joints demonstrate elevated toughness, efficiency, and stiffness in samples of two-layer twill fabric when the twill lines are oriented perpendicular to each other. Under these conditions, joint properties are measured at 0.89%, 14804.65 Nm, and 20.46 J, respectively. Increased fabric flexural rigidity yields advantages in terms of load distribution, load transfer efficiency, and dimensional stability. This study deepens the understanding of factors influencing joint strength, contributing valuable insights for the development of optimized joint designs and manufacturing processes. These advancements aim to enhance the performance and reliability of fabric/unsaturated polyester composites in applications requiring high strength and structural integrity.
Corticosteroid Injection in the Operative Hand Prior to a Trigger Finger or Carpal Tunnel Release: If It Is Not at the Surgical Site Then What Is the Big Deal?
Authors: Koso Riikka E. , Njoku-Austin Confidence O. , Piston Hannah E. , Mirvish Asher B. , Li Runjia , Fowler John R. 
Published: January 2024

Background: Patients who have had a corticosteroid injection at the surgical site within 90 days of trigger finger release (TFR) or carpal tunnel release (CTR) have an elevated risk of postoperative infection. Currently, it remains unknown if a preoperative injection in proximity to the surgical site for a separate complaint alters the risk of a postoperative infection. Methods: A retrospective chart review was performed on all patients who underwent TFR or CTR between 2010 and 2022. Patients who had a corticosteroid injection at or near the surgical site within 90 days of surgery were included. Outcome measures included uncomplicated healing, superficial infection requiring antibiotics, and deep infection (DI) requiring surgical debridement. Results: There were 564 cases in which a corticosteroid injection was performed within 90 days of TFR or CTR. Superficial infections occurred in 12 (2.1%), and DIs occurred in 6 (1.1%) cases. There was no significant difference in infection rates between the two groups relative to the location of the injection nor timing of the injection (0-30, 31-60, or 61-90 days prior to surgery). Conclusions: Patients who had an injection at the surgical site within 90 days of TFR or CTR had an elevated rate of postoperative infection compared with published rates in the literature. This study is unique in that preoperative injections at an adjacent site in the palm also correlated with an elevated rate of infection, similar to patients who had an injection at the surgical site. Level of Evidence: Level 4.
Single-center outcomes of Onyx Frontier™ and Resolute Onyx™ drug-eluting balloon-mounted stents for rescue stenting for acute large vessel occlusion
Authors: Mehta Shyle H. , White Timothy G. , Shah Kevin A. , Lynch Daniel G. , Werner Cassidy D. , Teron Ina , Link Thomas , Patsalides Athos , Woo Henry H. 
Published: January 2024

Background In cases where mechanical thrombectomy (MT) fails, rescue stenting may be necessary to achieve reperfusion; however, the lack of standardized techniques or devices poses a challenge. This series aims to present our early experience with the Onyx Frontier™ and Resolute Onyx™ balloon-mounted drug-eluting stents for rescue stenting. Methods A retrospective chart review was performed of all patients who underwent rescue stenting, in the setting of failed MT, using Onyx Frontier™ or Resolute Onyx™ stents at a single institution. Technical details, procedural complications, and patient outcomes were recorded for each case. Results Twenty-two Onyx Frontier™ and Resolute Onyx™ stents were deployed in 18 patients undergoing rescue stenting. Stent locations included the middle cerebral artery (36.4%), internal carotid artery (18.2%), vertebral artery (22.7%), and basilar artery (22.7%). The average National Institutes of Health Stroke Scale score before MT was 13.8 (range 0–31). The median initial modified Rankin Scale (mRS) score was zero, while the median mRS score at follow-up was three. Successful reperfusion, as assessed by TICI scores, was achieved in 43.8% of patients for TICI 3, 43.8% for TICI 2C, and 12.5% for TICI 2B. Post-revascularization, 16.7% of patients experienced hemorrhage, of which one patient (5.6%) had symptomatic hemorrhage. Conclusions Onyx Frontier™ and Resolute Onyx™ stents are well suited for rescue stenting in cases of failed MT. These balloon-mounted drug-eluting stents exhibit excellent navigability, rendering them appropriate for rescue revascularization procedures. Our findings demonstrate that these stents confer a high degree of technical success.
Carotid stenting for symptomatic carotid artery web: Multicenter experience
Authors: Pasarikovski Christopher R. , Lynch Jeremy , Corrin Michael , Ku Jerry C. , Kumar Ashish , Pereira Vitor M. , Krings Timo , da Costa Leodante , Black Sandra E. , Agid Ronit , Yang Victor XD. 
Published: January 2024

Objective Carotid artery webs are an underappreciated cause of recurrent ischemic stroke, and may represent a significant portion of cryptogenic stroke. Evidence-based guidelines for the management of symptomatic carotid webs do not exist. The goal of this study is to audit our local experience for patients with symptomatic carotid artery webs undergoing carotid stenting as a treatment option, along with describing the hypothesized dynamic physiology of carotid webs. Methods All patients undergoing stenting for symptomatic carotid artery web at two comprehensive regional stroke centers with high endovascular thrombectomy volume from January 1, 2012 to March 1, 2021 were included. The modified Rankin Scale (mRS) score was used to define functional outcome at 3 months after stenting. Results Fourteen consecutive patients with symptomatic carotid artery webs underwent stenting. Twelve patients were female (86%), with a median age of 54 (IQR, 48–64) years across all patients. Stroke was the qualifying event in 12 (86%) patients and TIA in 2. Eleven patients (11/14, 79%) achieved a mRS score of 0–2 at 90 days, 2 (14%) were mRS 3–5, and one patient was lost to follow-up. The median follow-up was 12 months (IQR, 10–12). There was no recurrent stroke or TIA like symptoms in any patients. Conclusions Carotid stenting appears to be safe at preventing recurrent stroke/TIA with a median follow-up of 12 months in this retrospective multicenter observational study.
Psychological Symptoms of COVID-19 Pandemic Among Community-Dwelling Older People in Oman and Associated Risk Factors
Authors: Al-Jadidi Saleha , Alharrasi Maryam , Al-Shukaili Ahmed , Alkalbani Ali , Muthukrishnan Akila 
Published: January 2024

Introduction The COVID-19 pandemic has led to a dramatic loss of human lives worldwide. Objective This study aimed to investigate the psychological factors of the COVID-19 pandemic in the community-dwelling older population. Method This was a cross-sectional study of older people aged ≥60 years with no mental or psychological illnesses. A total of 193 participants were recruited. The study questionnaire included anxiety- and depression-related questions tailored for the COVID-19 pandemic. The questionnaire was developed through a literature review and expert review. Data was collected from December 2020 to January 2022. Results The psychological symptoms of COVID-19 were high in this sample (mean 29.18 ± 3.57). Gender (female) was found to have a strong positive relationship with the psychological symptoms of COVID-19 score ( p = 0.003). Chronic illnesses (β = 0.19, p < 0.001), living alone (β = 0.39, p < 0.001), and having a family member or a friend with COVID-19 (β = 0.15, p < 0.001) were also found to have a strong positive relationship with the psychological symptoms of COVID-19 score. Conclusion The negative psychological effects of COVID-19 were high among the older population in Oman. In this study, female gender, chronic illnesses, living alone, and having a family member or a friend with COVID-19 were associated with worse COVID-19 psychological symptoms. Older women were affected by COVID-19 more than older men. In addition, those who had chronic illnesses, lived alone, or had a family member or a friend with COVID-19 were more psychologically burdened by the pandemic than those without those characteristics. Particular attention should be given to older adults who have chronic illnesses, live alone, or have a family member or a friend with COVID-19. Support groups and psychological counseling programs are essential for older people during a pandemic.
MACI Sandwich Technique With Autologous Bone Graft
Authors: Minas Tom 
Published: January 2024

Background: Osteochondral lesions of the knee are difficult to manage. Such lesions can be effectively treated with the matrix-induced autologous chondrocyte implantation (MACI) “sandwich” technique using autologous chondrocytes on porcine collagen membrane in conjuction with autologous cancellous bone grafting (ABG). Few studies have examined this technique to restore the osteochondral unit. Indications: The MACI “Sandwich” procedure is indicated when osteochondral lesions are larger than 2 cm2 in size and deeper than 8 to 10 mm, with symptoms consistent with the location of the lesion. Technique Description: The chondral defect is radically debrided back to healthy bone and cartilage tissue. The base of the bony cavity is drilled to enhance the vascular supply and promote healing. Next, the bony cavity is prepared to slightly undermine the subchondral bone surface around the articular margins, with the depth of the cavity wider than the opening, similar to a dental amalgam. The autologous cancellous bone is subsequently morselized and impacted up to the level of the native subchondral bone plate. The first MACI membrane with the cells facing up is placed directly onto the bone graft site and compressed with a neural patty. The neural patty is removed, and the second MACI membrane is then placed with the cells facing down. The edges are then micro-sutured to ensure stability. Results: The “sandwich” technique has superior survival rates compared with autologous bone grafting alone, with patients reporting decreased pain, improved function, and high satisfaction scores over a mid-term to long-term follow-up. Discussion/Conclusion: The MACI “sandwich” technique is an effective surgical intervention to restore the osteochondral unit and preserve the patient's native knee joint. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Low ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome
Authors: NaveenKumar Somanathapura K. , Tambralli Ajay , Fonseca Bruna Mazetto , Yalavarthi Srilakshmi , Liang Wenying , Hoy Claire K. , Sarosh Cyrus , Rysenga Christine E. , Ranger Caroline H. , Vance Caroline E. , Madison Jacqueline A. , Orsi Fernanda A. , Sood Suman L. , Schaefer Jordan K. , Zuo Yu , Knight Jason S. 
Published: January 2024

Abstract
Many patients with antiphospholipid syndrome had decreased ectonucleotidase activity on neutrophils and platelets, which enabled extracellular nucleotides to trigger neutrophil-platelet aggregates. This phenotype was replicated by treating healthy neutrophils and platelets with patient-derived antiphospholipid antibodies or ectonucleotidase inhibitors.
ADAMTS13 recovery in acute thrombotic thrombocytopenic purpura after caplacizumab therapy
Authors: Mingot-Castellano María-Eva , García-Candel Faustino , Martínez-Nieto Jorge , García-Arroba José , de la Rubia-Comos Javier , Gómez-Seguí Inés , Paciello-Coronel María-Liz , Valcárcel-Ferreiras David , Jiménez Moraima , Cid Joan , Lozano Miquel , García-Gala José-María , Angós-Vazquez Sonia , Vara-Pampliega Miriam , Guerra-Domínguez Luisa , Ávila-Idrobo Laura-Francisca , Oliva-Hernandez Ana , Zalba-Marcos Saioa , Tallón-Ruiz Inmaculada , Ortega-Sánchez Sandra , Goterris-Viciedo Rosa , Moreno-Jiménez Gemma , Domínguez-Acosta Lourdes , Araiz-Ramírez María , Hernández-Mateos Luis , Flores-Ballesteros Elena , del Río-Garma Julio , Pascual-Izquierdo Cristina 
Published: January 2024

Abstract
Caplacizumab prevents the interaction between von Willebrand factor and platelets and is used to treat immune thrombotic thrombocytopenic purpura (iTTP). Its administration has been associated with a delay in ADAMTS13 activity restoration after plasma exchange (PEX) suspension. We analyzed the outcomes of 113 iTTP episodes, 75 of which were treated with caplacizumab, in 108 patients from the Spanish Registry of Thrombotic Thrombocytopenic Purpura. Caplacizumab shortened the time to platelet count normalization and reduced PEX requirement, exacerbations, and relapses. There was no difference in the time to achieve ADAMTS13 activity ≥20% after PEX end between caplacizumab-treated and nontreated episodes (median [interquartile range], 14.5 [7.7-27.2] vs 13.0 [8.0-29.0] days, P = .653). However, considering the 36 episodes in which caplacizumab was started ≤3 days after iTTP diagnosis, the time for ADAMTS13 restoration from PEX end was higher than in those episodes in which caplacizumab was started &gt;3 days after iTTP diagnosis (20.0 [12.0-43.0] vs 11.0 [3.5-20.0] days, P = .003) or than in non-caplacizumab-treated episodes (P = .033). This finding could be related to a significantly shorter duration of PEX in early caplacizumab-treated episodes than in late caplacizumab-treated episodes (5.5 [4.0-9.0] vs 15.0 [11.0-21.5] days, P &lt; .001) or non-caplacizumab-treated episodes (11.0 [6.0-26.0] days, P &lt; .001). There were no differences in time to ADAMTS-13 restoration from PEX start (28.0 [17.2-47.5], 27.0 [19.0-37.5] and 29.5 [15.2-45.0] days in early caplacizumab-treated, late caplacizumab-treated and non-caplacizumab-treated episodes). Early administered caplacizumab does not prevent the requirement for immunosuppression but has beneficial effects by shortening PEX requirement without major safety concerns.
T-cell dysfunctions in myelodysplastic syndromes
Authors: Rodriguez-Sevilla Juan Jose , Colla Simona 
Published: January 2024

Abstract
Escape from immune surveillance is a hallmark of cancer. Immune deregulation caused by intrinsic and extrinsic cellular factors, such as altered T-cell functions, leads to immune exhaustion, loss of immune surveillance, and clonal proliferation of tumoral cells. The T-cell immune system contributes to the pathogenesis, maintenance, and progression of myelodysplastic syndrome (MDS). Here, we comprehensively reviewed our current biological knowledge of the T-cell compartment in MDS and recent advances in the development of immunotherapeutic strategies, such as immune checkpoint inhibitors and T-cell– and antibody–based adoptive therapies that hold promise to improve the outcome of patients with MDS.
Genome-wide molecular evolution analysis of the GRF and GIF gene families in Plantae (Archaeplastida)
Authors: Chen Xinghao , Zhang Jun , Wang Shijie , Cai Hongyu , Yang Minsheng , Dong Yan 
Published: January 2024

Abstract
Background
Plant growth-regulating factors (GRFs) and GRF-interacting factors (GIFs) interact with each other and collectively have important regulatory roles in plant growth, development, and stress responses. Therefore, it is of great significance to explore the systematic evolution of GRF and GIF gene families. However, our knowledge and understanding of the role of GRF and GIF genes during plant evolution has been fragmentary.

Results
In this study, a large number of genomic and transcriptomic datasets of algae, mosses, ferns, gymnosperms and angiosperms were used to systematically analyze the evolution of GRF and GIF genes during the evolution of plants. The results showed that GRF gene first appeared in the charophyte Klebsormidium nitens, whereas the GIF genes originated relatively early, and these two gene families were mainly expanded by segmental duplication events after plant terrestrialization. During the process of evolution, the protein sequences and functions of GRF and GIF family genes are relatively conservative. As cooperative partner, GRF and GIF genes contain the similar types of cis-acting elements in their promoter regions, which enables them to have similar transcriptional response patterns, and both show higher levels of expression in reproductive organs and tissues and organs with strong capacity for cell division. Based on protein–protein interaction analysis and verification, we found that the GRF–GIF protein partnership began to be established in pteridophytes and is highly conserved across different terrestrial plants.

Conclusions
These results provide a foundation for further exploration of the molecular evolution and biological functions of GRF and GIF genes.