bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formação docente para a Educação Profissional como objeto de estudo nas dissertações do PPGEP/IFRN (2015-2022)
Authors: Santos Luiz Antonio da Silva dos , Oliveira Rayane Lourenço de , PAZ Edna Oliveira da Paz , Tavares Andrezza Maria Batista do Nascimento 
Published: December 2023

A presente pesquisa tem como foco central mapear as produções científicas que versam sobre formação docente no contexto da Educação Profissional (EP), tendo como fonte de análise dissertações publicadas pelo Programa de Pós-graduação do Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte (PPGEP/IFRN), no período de 2015 a 2022, para, assim, auxiliar teoricamente os estudos e pesquisas subsequentes sobre a temática. Nessa perspectiva, foram analisadas vinte e seis dissertações coletadas no site do PPGEP com o aporte do Repositório Institucional do IFRN. A análise considerou a dimensão histórica das políticas educacionais formativas, bem como os direcionamentos à temática, ancorando-se em uma pesquisa com instrumentação bibliográfica e documental, mediante uma abordagem de caráter qualitativo que dialoga com o método quanti-qualitativo na compreensão dos dados. Os resultados apontam, dentre outros, a preocupação com a endogenia acadêmica, que se configura fator limitante na produção científica; as barreiras na implementação do Ensino Médio Integrado (EMI); a falta de formação pedagógica para profissionais não licenciados que ingressam na docência; os efeitos formativos do Programa Institucional de Bolsas de Iniciação à Docência (PIBID); a lenta evolução das políticas de formação de professores para a EP; a falta de identidade docente em instituições como o IFRN; a mudança de foco nas reuniões pedagógicas do IFRN; e a necessidade de uma formação inclusiva para pessoas com deficiência na EP.
Palavras-chave: Estado do conhecimento; Educação profissional; Formação Docente. Dissertações; PPGEP/IFRN.
Matrix Metalloproteinase-7 in Urinary Extracellular Vesicles Identifies Rapid Disease Progression in Autosomal Dominant Polycystic Kidney Disease
Authors: van Heugten Martijn H. , Blijdorp Charles J. , Arjune Sita , van Willigenburg Hester , Bezstarosti Karel , Demmers Jeroen A.A. , Musterd-Bhaggoe Usha , Meijer Esther , Gansevoort Ron T. , Zietse Robert , Hayat Sikander , Kramann Rafael , Müller Roman-Ulrich , Salih Mahdi , Hoorn Ewout J. 
Published: December 2023

Significance Statement
There is an unmet need for biomarkers of disease progression in autosomal dominant polycystic kidney disease (ADPKD). This study investigated urinary extracellular vesicles (uEVs) as a source of such biomarkers. Proteomic analysis of uEVs identified matrix metalloproteinase 7 (MMP-7) as a biomarker predictive of rapid disease progression. In validation studies, MMP-7 was predictive in uEVs but not in whole urine, possibly because uEVs are primarily secreted by tubular epithelial cells. Indeed, single-nucleus RNA sequencing showed that MMP-7 was especially increased in proximal tubule and thick ascending limb cells, which were further characterized by a profibrotic phenotype. Together, these data suggest that MMP-7 is a biologically plausible and promising uEV biomarker for rapid disease progression in ADPKD.

Background
In ADPKD, there is an unmet need for early markers of rapid disease progression to facilitate counseling and selection for kidney-protective therapy. Our aim was to identify markers for rapid disease progression in uEVs.

Methods
Six paired case–control groups (n=10–59/group) of cases with rapid disease progression and controls with stable disease were formed from two independent ADPKD cohorts, with matching by age, sex, total kidney volume, and genetic variant. Candidate uEV biomarkers were identified by mass spectrometry and further analyzed using immunoblotting and an ELISA. Single-nucleus RNA sequencing of healthy and ADPKD tissue was used to identify the cellular origin of the uEV biomarker.

Results
In the discovery proteomics experiments, the protein abundance of MMP-7 was significantly higher in uEVs of patients with rapid disease progression compared with stable disease. In the validation groups, a significant >2-fold increase in uEV-MMP-7 in patients with rapid disease progression was confirmed using immunoblotting. By contrast, no significant difference in MMP-7 was found in whole urine using ELISA. Compared with healthy kidney tissue, ADPKD tissue had significantly higher MMP-7 expression in proximal tubule and thick ascending limb cells with a profibrotic phenotype.

Conclusions
Among patients with ADPKD, rapid disease progressors have higher uEV-associated MMP-7. Our findings also suggest that MMP-7 is a biologically plausible biomarker for more rapid disease progression.
Pseudosarcoptic mange in a child. Case from practice
Authors: Sagitova G. R. , Antonova A. A. , Smirnova E. V. , Sereda V. M. 
Published: December 2023

The article describes a clinical case of pseudoscabies. The parents of the child G., 10 yearsт old, turned to the pediatrician at the place of residence with complaints about sluggish and long-lasting rashes in the neck area on the left. The boy has been ill for two months. He was observed by a dermatovenereologist with suspected allergic dermatitis, received treatment with desensitizing drugs and corticosteroids. It was noteworthy that on the skin of the neck on the left, multiple papules of a rounded shape, pink in color were visualized, some of them were covered with hemorrhagic crusts. Due to the lack of effect from therapy and due to the fact that pseudo-scabies was suspected, a 10 % sodium benzyl benzoate ointment was prescribed. On the 4th day from the start of therapy, there was a positive trend. Thus, this clinical case is of practical interest for attracting the attention of doctors to a thorough history taking, searching for the causes leading to a protracted course of the disease and timely change of treatment regimen.
Effects of influenza vaccination on the morbidity and severity of COVID-19 in children
Authors: Ponomareva Yu. V. , Shisimorov I. N. , Magnitskaya O. V. , Plakhotnyuk T. V. , Krasnova K. Sh. 
Published: December 2023

The pandemic of a new coronavirus infection COVID-19 initiated research to find methods of non-specific influence on the immune system that can change the course of infectious diseases. Adult study results have been demonstrated the positive effect of seasonal influenza vaccination on morbidity, hospitalization rates, and reducing the severe forms of SARS-CoV-2 infection. That suggests a similar action in children. The aim of the study: to establish the possible impact of influenza vaccination on the morbidity and severity of COVID-19 in children in Volgograd. Materials and methods. The 303 children 3-17 years old without a history of chronic diseases were included in comparative prospective cohort study on the impact of influenza vaccination (235/303) on morbidity and severity of a new coronavirus infection COVID-19 vs non-vaccinated group (68/303). Results. All children with new coronavirus infection COVID-19 (diagnosis confirmed by laboratory testing - U07.1) had mild symptoms of the disease. In all age groups, the morbidity and the severity of the new coronavirus infection COVID-19 among children vaccinated against influenza did not have significant differences with non-vaccinated group. Conclusion. The results of our study did not support the hypothesis of a protective role of seasonal influenza vaccination on the morbidity and severity of COVID-19 in healthy children. Further research is needed to establish the effect of influenza vaccination on the severity of COVID-19 in children with chronic diseases.
Polypous rhinosinusitis: possibilities of anti-inflammatory therapy
Authors:   Vladimirsky Moscow Regional Research Clinical Institute, Moscow, 129110, Russia, Savlevich E. L. , Esakova N. V. ,   Academician Veltishchev Research Clinical Institute of Pediatrics and Pediatric Surgery,  Pirogov Russian National Research Medical University, Moscow, 125412, Russia, Egorov V. I. ,   Vladimirsky Moscow Regional Research Clinical Institute, Moscow, 129110, Russia
Published: December 2023

Current treatments for polypous rhinosinusitis (PRS) relieve symptoms but do not eliminate recurrence rates, highlighting research relevance, molecular targets, inflammation, and nasal mucosal function. Patients and methods. Formed 2 groups of patients (main (n = 44) and comparison (n = 20)) diagnosed with PRS. Patients of the main group were additionally prescribed the anti-inflammatory oral drug "Reglisam" for 90 days in the treatment regimen. In dynamics, the groups underwent endoscopy of the nasal cavity, scoring by VAS (from 0 to 3 points) of complaints and local symptoms of inflammation. Results. By the 45th day, in patients of the main group, the severity of sneezing, coughing, headache/facial pain was lower by 77, 56 and 87%, respectively, relative to the comparison group (p < 0.05), differences in the severity of symptoms of nasal congestion, discharge, postnasal drip was 24–34% (p < 0.05). By the 90th day in the main group, sneezing, headache/facial pain, and cough were completely stopped, in the comparison group, the symptoms persisted. In the main group, the degree of nasal congestion and nasal discharge were minimal, postnasal drip – 60% lower relative to comparison (p < 0.05). The proportion of patients in the main group with complaints of postnasal drip and nasal discharge by day 90 decreased by 41% and 32%, respectively (p < 0.05), sneezing, headache/facial pain and cough were absent. In the comparison group, the frequency of symptoms over time did not change significantly. According to endoscopy in the main group on the 90th day of treatment, mucous discharge was absent in 55% of patients (n = 24), edema was not recorded in 16% (n = 7). In the comparison group, mucous discharge was absent only in 30% (n = 6), edema persisted in all patients. The severity of mucous secretions and edema in patients of the main group was more than 2.5 times less than in the comparison group (p < 0.05). Conclusion. Treatment of PRS with the inclusion "Reglisam", in comparison with monotherapy with intranasal glucocorticosteroids, more effectively allows to stop swelling and inflammation in the nasal mucosa, improve mucociliary transport and drainage of the paranasal sinuses, normalize nasal breathing and improve the quality of life of patients.
Editorial
Authors: Geurs Karst , Ritsema van Eck Jan 
Published: December 2023

That land-use and transport systems are interdependent and characterized by a two-way interaction is a well-known fact. The spatial configuration of activities influences the level and characteristics of transportation demand, and conversely, the location and quality of transportation infrastructure affects how activities are organized in space. Since the 1960s, several methodologies and models have been developed and used to examine the land-use and transport patterns and change. The research issues addressed using these models have, since the 1990s, been broadened to include sustainability impacts in transport policy, thereby strongly increasing modelling demands and raising several research challenges. This was the theme of a special session on ‘Land Use Transport Interaction Modelling and Sustainability’, as part of the international conference ‘Framing Land Use Dynamics’ held in April 2003 at Utrecht University (UU) in the Netherlands. The conference was organised as part of the Utrecht University’s multidisciplinary research programme, ‘Networks in the Delta’, aimed at developing a theoretical and methodological framework for understanding and modelling the complex interactions between socio-economic and environmental systems (see website Networks in the Delta (2004) for a full description). The papers included in this special issue of the European Journal of Transport and Infrastructure Research were presented at the conference under the theme, ‘Infrastructure, mobility and land-use planning’, focusing on transportation and land-use dynamics. Papers describe experiences with land-use and transport interaction models as impact assessment and policy appraisal tools, with contributions covering different local, regional and national spatial scales in Western European contexts, in particular, the United Kingdom, Germany and the Netherlands.
O triunfo do urbano
Authors: Paquot Thierry , Ribeiro Peixoto Elane 
Published: December 2023

O presente artigo situa as discussões de Françoise Choay sobre o mundo contemporâneo, no qual ela reconhece o triunfo do urbano em escala planetária. Os termos “non-ville” [não cidade] e “non-campagne” [não campo] são propostos pela autora para indicar o fim da cidade como conjunção entre civitas e urbs — isto é, uma comunidade reunida em um espaço definido e delimitado e que se distingue, por oposição, ao campo. São termos-chave para o entendimento de um fenômeno de dispersão do urbano decorrente da inovação dos meios de transporte e comunicação que constituem redes técnicas que conformam os espaços e os comportamentos. As posições de Choay são cotejadas com as de pensadores como Bernard Charbonneau, Henri Lefebvre, Maurice Bardet, Melvin Webber, Francesco Indovina, entre outros. A tradução do artigo, originalmente escrito em francês, deu atenção ao ritmo do texto, respeitando sua pontuação, e manteve os títulos citados e os neologismos no idioma original, indicando a tradução dos últimos entre colchetes. Notas foram incluídas para auxiliar os leitores brasileiros que, porventura, não estejam familiarizados com os autores mencionados.
POSSIBILIDADE DE UMA TERCEIRA VIA DE SOLUÇÃO HETEROCOMPOSITIVA DE CONFLITOS QUE ENVOLVAM COMPLEXIDADE JURÍDICA E VULTOSO CONTEÚDO ECONÔMICO, SOB A PERSPECTIVA DA COMPETÊNCIA JURISDICIONAL ADEQUADA
Authors: Guedes Marilia Garcia , Guedes Jefferson Carús 
Published: December 2023

O presente artigo trata da viabilidade jurídica para uma política pública de cooperação operacional e financeira entre o poder judiciário, entidades privadas e/ou pessoas físicas e jurídicas para o exercício da jurisdição, observada a competência adequada, mediante a análise pelos interessados da expertise dos possíveis julgadores lançados em lista, conforme convenção processual derivada de negócio jurídico cujo objeto seja patrimonial, disponível, de alta complexidade jurídica, técnica ou financeira e nos quais não haja vulnerabilidades dos envolvidos. Para tanto, demonstrar-se-á o cenário jurisdicional atual ao qual estão submetidos os potenciais interessados em um serviço adjudicatório estatal assemelhado, em certos aspectos, à arbitragem. Diante da constatação da existência deste agente racional e de suas necessidades será possível traçar – entre as duas formas de heterocomposição atualmente disponíveis no arcabouço jurídico nacional (jurisdição estatal e arbitragem) – uma terceira via que ofereça alguns dos traços atrativos de ambas. O procedimento metodológico utilizado será o dedutivo, partindo-se da análise macro analítica dos institutos inerentes à jurisdição e à arbitragem, aplicando- os na construção de uma forma de distribuição da competência e na maneira de prestação do serviço judicial adequados à necessidade do agente racional eleito para estudo, sem que haja ônus adicional financeiro ao Estado-Juiz ou prejuízos aos demais jurisdicionados, mediante mecanismos de gestão e de compensação.
Artificial Neural Network-Based Computational Algorithm of Inverse Sumudu Transform Applied to Surface Transient Electromagnetic Sounding Method
Authors: Epov M.I. , Danilovskiy K.N. , Nechaev O.V. , Mikhaylov I.V. 
Published: December 2023

Abstract
––The paper discusses the results of the development of a deep learning-based algorithm of the inverse Sumudu transform applied to the problem of on-ground non-stationary electromagnetic sounding. The Sumudu transform has potential for solving forward geoelectric problems in three-dimensional earth models because, unlike using the Laplace or Fourier transform, the Sumudu image of a real function is also a real function. Thus, there is no need to use complex numbers in subsequent calculations, which reduces computational costs and memory requirements in case of successful determination of the Sumudu image of the function. The disadvantages of the approach include the absence of an explicit method for calculating the inverse transform. The inversion can be done by solving the corresponding Fredholm integral equation of the first kind, but this is a poorly conditioned task leading to high requirements for the accuracy of the Sumudu image. The use of modern machine learning techniques can provide a method that is more robust to noise in the input data. This paper describes the process of creating a training dataset and developing a neural network algorithm; we evaluate the accuracy and performance of the obtained solution. The proposed method can contribute to the development of new approaches to physical processes modeling as well as to analysis, processing and interpretation of measured geophysical data.
Land Subsidence Prediction in Coal Mining Using Machine Learning Models and Optimization Techniques
Authors: jahanmiri shirin , Noorian-Bidgoli Majid 
Published: December 2023

Abstract

Land surface subsidence is an environmental hazard resulting from the extraction of underground resources. In underground mining, when mineral materials are extracted deep within the ground, the emptying or caving of the mined spaces leads to vertical displacement of the ground, known as subsidence. This subsidence can extend to the surface as troughs subsidence, as the movement and deformation of the hanging-wall rocks of the mining stope propagate upwards. Accurately predicting subsidence is crucial for estimating damage and protecting surface buildings and structures in mining areas. Therefore, developing a model that considers all relevant parameters for subsidence estimation is essential. In this article, we discuss the prediction of land subsidence caused by the caving of a stop's roof, focusing on coal mining using the longwall method. We consider a total of 11 parameters related to coal mining, including mining thickness and depth (related to the deposit), as well as density, cohesion, internal friction angle, elasticity modulus, bulk modulus, shear modulus, Poisson's ratio, uniaxial compressive strength, and tensile strength (related to the overburden). We utilize information collected from 14 coal mines regarding mining and subsidence to achieve this. We then explore the prediction of subsidence caused by mining using the gene expression programming (GEP) algorithm, optimized through a combination of the artificial bee colony (ABC) and ant lion optimizer (ALO) algorithms. Modeling results demonstrate that combining the GEP algorithm with optimization based on the ABC algorithm yields the best subsidence prediction, achieving a correlation coefficient of 0.96. Furthermore, sensitivity analysis reveals that mining depth and density have the greatest and least effects, respectively, on land surface subsidence resulting from coal mining using the longwall method.
The most sustainable high entropy alloys for the future
Authors: Nomine Alexandre , El-Kasmi Ayyoub , Beaulieu Danielle , Ouahri Outhmane , Nguyen Thuy Huong , Amzil Wassim , Droussi Aymane , Kuksa Oleksandra , Katsarou Eirin , Labba Chahrazed , Boyer Anne , Henein Hani , Belmonte Thierry , Mitrofanova Elena , Samper Agnes , Milichko Valentin , Chernoburova Olga , Chagnes Alexandre , Cathelineau Michel , Cvelbar Uros , Zavasnik Janez 
Published: December 2023

Abstract
Because of the enormous number of potential compositions comparable to the number of stars in the universe, high entropy alloys (HEAs) are a virtually endless source of materials possessing versatile properties. Among them, HEAs are promising substitutes for critical elements such as rare earths or platinum group metals. Random or incremental development methods are neither practical nor efficient for exploration. Targeted guessing with sustainability in mind is a necessary enabler, but choosing the suitable sustainable composition of HEAs is challenging. In this paper, we examine the most sustainable HEAs among 30,201 alloys and extract the best 500 that will most likely shape the future of humanity. We consider various sustainability criteria such as carbon footprint, ESG ratings, production compatibility levels and reserves. The results provide a roadmap for HEA scientists and direct their experimental efforts towards the most sustainable compositions, supporting industry efforts while preserving time and resources.
A method for determination of the magnetization direction by probability tomography
Authors: Kim Jang Son , Kim Gang Sop , Kim Il Hyok 
Published: December 2023

Abstract

Knowledge of the total magnetization direction of the magnetic anomaly plays an important role in the interpretation of the magnetic survey data. Common methods for estimating the magnetization direction are those for calculating the correlation between the reduced-to-the-pole (RTP) field and the various transformation data of magnetic anomalies. A new method for estimating the magnetization direction through the analysis of magnetic anomalies by probability tomography in the presence of residual magnetization is proposed. The occurrence probability function of magnetic anomalies using probability tomography with the any magnetization inclination and declination was calculated, and then its maximum was searched. Then, the occurrence probability function maxima (OPFMs) at different magnetization inclinations and declinations were calculated and found that the correct magnetization direction corresponds to the largest value of the OPFMs. The proposed method is tested on both synthetic and field data. The results showed that this method was effective in a variety of situations and the computational process was simpler than the other methods.
Hypogonadism as a Consequence of Craniopharyngioma in Female Patients: Comparison of Childhood and Adult Onset and Effects of Estrogen Replacement Therapy
Authors: Ilovayskaya Irena , Zektser Vita 
Published: December 2023

Abstract
Purpose: 1) to compare clinical, biochemical features in female patients with hypoestrogenism due to childhood- and adult-onset CP; 2) to reveal effects of estrogen replacement therapy in female patients with childhood-onset CP.
Methods: Thirty-seven women that received specific treatment for CP in the period from 1980 to 2019 were recruited: 21 with childhood-onset and 16 with adult-onset CP. Clinical and hormonal characteristics were evaluated. Seventeen-beta-estradiol 2 mg and dydrogesterone 10 mg in sequential regiment was used in 18 childhood-onset cases. Mean follow-up was 31 months.
Results: Amenorrheic women with childhood- and adult-onset CP presented with the same complaints except for lack of genital hair and breast hypoplasia, which were common in patients with childhood-onset CP. BMI was lower in childhood-onset CP group, as was the proportion of overweight patients. They had more favorable lipid profile. The levels of estradiol, testosterone and DHEA-S were low and did not differ. Uterine and ovary volumes were reduced in all patients, but the decline was noticeable in the childhood-onset group. Mineral bone density of lumbar vertebrae was diminished in childhood-onset group. Estrogen therapy in these patients led to clinical improvement: increase in BMD in lumbar spine without negative changes in BMI and/or lipid profile.
Conclusions: study showed that women with childhood-onset CP had less negative metabolic changes. However, they have more pronounced breast and uterus hypoplasia and lower BMD in lumbar spine. The estrogen replacement therapy led to clinical improvement and BMD increase in lumbar spine without increase of BMI and/or lipid profile changes.