bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN DUKUNGAN KELUARGA DENGAN PEMANFAATAN LAYANAN CST (CARE, SUPPORT, AND TREATMENT) ODHA DI KOTA TASIKMALAYA
Authors: Mulyana Hilman , Hayati Euis Teti , Rosalinda Ismi 
Published: November 2023

Latar Belakang Indonesia adalah 1 dari 3 negara yang merupakan daerah infeksi HIV, sampai tahun 2017 terdapat 10.376 penderita HIV dan 673 penderita AIDS. Provinsi Jawa Barat menduduki posisi ke 4 dari 10 kasus HIV terbanyak, tahun 2017 terdapat 501 penderita HIV/AIDS dan sampai pada bulan Maret 2018 ODHA di Kota Tasikmalaya sudah sampai 522 orang, dari sekian banyak yang mengikuti program CST (Care, support, and Treatment) hanya 159 ODHA, padahal program tersebut membantu ODHA dan keluarga menyelesaikan permasalahan medis dan psikologis yang dihadapi, sehingga memerlukan dukungan keluarga yang berperan pentingÂ baik dari segi kepatuhan pengobatan, motivasi hidup dan sejenisnya. Tujuan penelitian ini adalah untuk mengetahui hubungan dukungan keluarga terhadap layanan CST ODHA. Metode penelitian kuantitatifÂ dengan pendekatan cross sectional. Populasi penelitian ini adalah sebanyak 159 ODHA. Sample diambil secara random sampling sebanyak 45 ODHA. Hasil penelitian menunjukan sebagian besar ODHA yang mendapatkan dukungan keluarga sebanyak 36 orang (80%) dan memanfaatan layanan CST dengan baik sebanyak 42 orang (93,9%). Kesimpulan dari penelitian ini berdasarkan hasil uji Rank Spearman menunjukan ada hubungan yang signifikan antara hubungan dukungan keluarga dengan pemanfaatan layanan CST dengan p-value 0,034 0,05
Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway
Authors: Sun Ruo-Chuan , Li Jing , Li Ya-Xian , Wang Hui-Zhen , Dal Emre , Wang Ming-Liang , Li Yong-Xiang 
Published: November 2023

BACKGROUND
The role of Tousled-like kinase 1 (TLK1) in in gastric cancer (GC) remains unclear.
AIM
To investigate the expression, biological function, and underlying mechanisms of TLK1 in GC.
METHODS
We measured TLK1 protein expression levels and localized TLK1 in GC cells and tissues by western blot and immunofluorescence, respectively. We transfected various GC cells with lentiviruses to create TLK1 overexpression and knockdown lines and established the functional roles of TLK1 through in vitro colony formation, 5-ethynyl-2`-deoxyuridine, and Transwell assays as well as flow cytometry. We applied bioinformatics to elucidate the signaling pathways associated with TLK1. We performed in vivo validation of TLK1 functions by inducing subcutaneous xenograft tumors in nude mice.
RESULTS
TLK1 was significantly upregulated in GC cells and tissues compared to their normal counterparts and was localized mainly to the nucleus. TLK1 knockdown significantly decreased colony formation, proliferation, invasion, and migration but increased apoptosis in GC cells. TLK1 overexpression had the opposite effects. Bioinformatics revealed, and subsequent experiments verified, that the tumor growth factor-beta signaling pathway was implicated in TLK1-mediated GC progression. The in vivo assays confirmed that TLK1 promotes tumorigenesis in GC.
CONCLUSION
The findings of the present study indicated that TLK1 plays a crucial role in GC progression and is, therefore, promising as a therapeutic target against this disease.
Mucosal esophageal carcinoma following endoscopic submucosal dissection with giant gastric metastasis: A case report and review of literature
Authors: Yang Mei-Qi , Sun Ming-Jun , Zhang Hui-Jing 
Published: November 2023

BACKGROUND
Esophageal carcinoma is a highly aggressive digestive cancer responsible for a notable proportion of cancer-related deaths worldwide. Its elevated metastatic rate contributes to a poor prognosis in affected patients. In this case review, we aim to summarize the metastatic characteristics of intramural gastric metastasis (IGM) in mucosal esophageal squamous carcinoma.
CASE SUMMARY
A 56-year-old man was admitted to our hospital because of a dry cough with an esophageal sensation for one year. Endoscopic examination revealed a 2.0 cm 1.0 cm, superficial esophageal squamous cell carcinoma, and the patient underwent endoscopic submucosal dissection (ESD). Fifteen months after ESD, positron emission tomography/computed tomography revealed that the metabolism of the stomach cardia wall had increased slightly. However, the mucosa of the gastric cardia was smooth under gastroendoscopy. Two years after ESD, endoscopic examination revealed a giant gastric cardia carcinoma, while the esophageal mucosa was smooth, and no advanced cancer was found. A biopsy of the gastric cardia indicated squamous-cell carcinoma. The patient received immunochemotherapy and radiotherapy for esophageal cancer for 8 mo and is currently under follow-up.
CONCLUSION
Early-stage esophageal carcinoma with IGM is rare. Despite the ESD of the primary lesion, IGM may still occur and should be closely monitored after ESD.
Perceived relevance of oral biology: a comparative study among dental interns and faculty
Authors: Shakeel Sadia , Jahangir Kaynat , Fahim Ayesha , Shahid Tayyaba Nayab , Azhar Ahmad , Chaudhry Ammara 
Published: November 2023

Background & Objective: This study aims to compare and examine the distinctive perspectives of dental trainees and distinguished faculty members toward the significance of oral biology subject for dentistry, clinical training, and dental education.
Methodology: A prevalidated questionnaire consisting of two sections was distributed through Google Forms and handouts to dental interns and faculty members of basic and clinical departments of different dental institutes and hospitals oh Punjab. The data was collected and statistically analyzed using IBM-SPSS version 25. The chi-square test was applied to check the significance of questions regarding perception of oral biology. A p-value of less than 0.05 was considered as the threshold for statistical significance.
Results: Both groups perceived high relevance of oral biology towards dentistry with slightly more relevance reported by dental interns regarding the importance of oral biology for dental education and clinical training. Regarding the data collected from clinical dental departments Oral surgery department showed the highest relevance of oral biology with dentistry whereas the Orthodontic department considered oral biology most relevant for future clinical training and practice.
Conclusions: Dental faculty and interns emphasized the importance of oral biology as a discipline for dentistry, but interns reported substantial application for relevance related to future clinical training and practice.
Enseñanza de las Matemáticas Mediadas por las TIC
Authors: Niño Merlo Carlos Andrés 
Published: November 2023

El propósito general de este artículo es analizar la incidencia de las TIC en la enseñanza de las matemáticas. Para ello se utilizó el método de revisión bibliográfica o revisión documental, recopilando artículos científicos relacionados con el objetivo de investigación y publicados en revistas indexadas en el período no mayor a 5 años, de igual manera esta información se analizó y organizo en una matriz analítica y documental, teniendo en cuenta los criterios de inclusión y exclusión de los diferentes artículos, donde se logró identificar que la enseñanza de las matemáticas está en un auge de evolución hacia la interacción y mediación de las TIC, dado que esto permite una mayor interrelación entre docente, contenidos y estudiantado en general, siendo así un recurso que ha transformado la enseñanza y el aprendizaje de las matemáticas al proporcionar herramientas significativas que hacen que las matemáticas sean más accesibles, interactivas y efectivas, al tiempo que mejoran la resolución de problemas y la colaboración entre docentes y estudiantes, además permiten la adaptación de los materiales y recursos de aprendizaje a las necesidades individuales de los estudiantes, fortaleciendo los procesos de enseñanza y aprendizaje.
Development Of Curriculum Of Anatomy For BDS Students In UZ, Harare: A Survey-Based Study
Authors: Khan Maimoona 
Published: November 2023

Objective: To evaluate and optimize the anatomy curriculum for BDS students in UZ. Study design: It is a survey-based study. Place and duration of study: A six-month study was carried out in the Anatomy Department, College of Health Sciences, University of Zimbabwe, Harare (March to August 2020). Material and Methods: A survey-based study was conducted in UZ, College of Health Sciences. To collect the data, two separate structured questionnaires were prepared. The structured questionnaires were then administered to medical faculty, BDS students of 3rd, 4th & 5th yr and practising dentists & internees, respectively. The sample size of the study was 70. Results: The data collected via the two structured questionnaires was analyzed. Analysis showed that all the stakeholders thought that the core dentistry subjects should be introduced earlier to the BDS students. Moreover, it was recommended that CBL/PBL be added to the curriculum to make the overall BDS curriculum more effective. Conclusion: The majority of the faculty members, BDS students, dentists and internees thought that the content of Anatomy for BDS students should be concise, specific and pertinent. The respondents supported the incorporation of CBL/PBL in the existing curriculum to make it more worthwhile.
A Dark Siren Measurement of the Hubble Constant with the LIGO/Virgo Gravitational Wave Event GW190412 and DESI Galaxies
Authors: Ballard W. , Palmese A. , Hernandez I. Magaña , BenZvi S. , Moon J. , Ross A. J. , Rossi G. , Aguilar J. , Ahlen S. , Blum R. , Brooks D. , Claybaugh T. , de la Macorra A. , Dey A. , Doel P. , Forero-Romero J. E. , A Gontcho S. Gontcho , Honscheid K. , Kremin A. , Manera M. , Meisner A. , Miquel R. , Moustakas J. , Prada F. , Sanchez E. , Tarlé G. , Zhou Z. ,   DESI Collaboration
Published: November 2023

Abstract
We present a measurement of the Hubble Constant H
0 using the gravitational wave event GW190412, an asymmetric binary black hole merger detected by LIGO/Virgo, as a dark standard siren. This event does not have an electromagnetic counterpart, so we use the statistical standard siren method and marginalize over potential host galaxies from the Dark Energy Spectroscopic Instrument (DESI) survey. GW190412 is well-localized to 12 deg2 (90% credible interval), so it is promising for a dark siren analysis. The dark siren value for

H

0

=

85.4

−
33.9

+
29.1

km s−1 Mpc−1, with a posterior shape that is consistent with redshift overdensities. When combined with the bright standard siren measurement from GW170817 we recover

H

0

=

77.96

−
5.03

+
23.0

km s−1 Mpc−1, consistent with both early and late-time Universe measurements of H
0. This work represents the first standard siren analysis performed with DESI data, and includes the most complete spectroscopic sample used in a dark siren analysis to date.
Chapitre 7. L’âme et le corps à travers le droit romain et le droit canon
Authors: Comiti Vincent-Pierre 
Published: November 2023

Au sein de ce travail sont abordés quelques éléments historiques sur l’histoire de l’évolution de la perception des liens entre l’âme et le corps et la modification de la place de l’âme au sein des droits canon et romain.
Comments on "Comparison of immediate withdrawal and stepwise reduction in duration of non-invasive ventilation in chronic obstructive pulmonary disease patients presenting with acute hypercapnic respiratory failure"
Authors: Rathi Vidushi 
Published: November 2023

Dear Editor, The recent study published by Purohit et al. provides new evidence on the safety of immediate withdrawal of non-invasive ventilation (NIV) in chronic obstructive pulmonary disease (COPD) patients admitted with acute hypercapnic respiratory failure (AHRF) after recovery...
Challenges in Management of a Patient Presenting with Obsessive–Compulsive Disorder after Head Injury
Authors: Naskar Chandrima , Gupta Surabhi , Sahoo Swapnajeet , Mehra Aseem , Grover Sandeep 
Published: November 2023

Abstract
In a subgroup of patients, obsessive–compulsive disorder (OCD) is associated with organic conditions such as head injury. In general, different studies evaluating the efficacy and effectiveness of nonpharmacological and pharmacological interventions in patients with OCD exclude patients with OCD associated with organic conditions. Hence, there is little information about the difficulties faced in managing these patients. In this report, we present a young male who presented with OCD after the head injury, in whom it was not possible to carry out exposure and response prevention (ERP) therapy, as recommended due to the poor insight and associated cognitive impairment. We managed the patient with a combination of psychoeducation, ERP, using positive reinforcement and supportive therapy.
Childhood obesity: A cross-sectional study among children aged 6–12 years attending pediatric outpatient department of a tertiary care teaching hospital in Kolkata, India
Authors: Ray Kuntala , Basu Mausumi , Mishra Ankita , Shukla Vineeta , Saha Ripan , Mandal Murari M 
Published: November 2023

Abstract

Background:
Children who develop obesity in the early years of their lives tend to remain so in their adolescence and adulthood and are at a higher risk of developing non-communicable diseases.

Objectives:
The present study was conducted to estimate the prevalence of overweight and obesity among children attending a pediatric outpatient department (OPD) of a tertiary care teaching hospital in Kolkata and to identify the factors associated with overweight and obesity among them.

Materials and Methods:
An observational study, cross-sectional in design, was conducted among children aged 6–12 years attending a pediatric OPD of a tertiary care teaching hospital in Kolkata from October to December 2021. Data were collected from 223 participants using a predesigned, pretested, and structured schedule by face-to-face interviews with their guardians, spot observation, and anthropometric measurements. We summarized the data with the help of suitable descriptive statistics. Multivariable binary logistic regression was performed to find the factors associated with overweight to obese nutritional status. All statistical analyses were performed using Statistical Package for the Social Sciences software (SPSS) version 25.0.

Results:
Out of 223 participants, 48% belonged to the age group of 6–8 years. The proportion of male-to-female children was nearly equal. About 22% of the study population were overweight to obese. The factors associated with overweight to obese nutritional status were less duration of outdoor play, frequent intake of processed meat, and the occasional intake of green leafy vegetables.

Conclusion:
A significant proportion of the children attending pediatric OPD were overweight to obese. Children must be motivated by parents and teachers for adequate physical activity and avoid consuming too much fast food.
A SPART missense mutation causes Troyer syndrome in two siblings
Authors: Alotaibi Maha A , A Almutairi Hamaed , Alsharkawy Ali A 
Published: November 2023

Abstract
Troyer syndrome, a rare autosomal-recessive disorder, manifests with complex spastic paraplegia. In Ohio, Amish families were the first to be reported with this syndrome. The neurological and musculoskeletal symptoms include short stature, dysarthria, distal amyotrophy, and spastic paralysis. A mutation in the SPGP20 gene, located on chromosome 13q13, results in the loss of the Spartin proteins, the source of pathogenicity. Spartin is a multifunctional protein thought to be crucial for neuron viability. Here, we report the clinical and molecular diagnostic findings of Troyer syndrome in two siblings from a consanguineous family in Saudi Arabia. The clinical phenotypes of the patients showed short stature and intellectual disability. The molecular genetic test, including whole-exome sequencing, was performed to identify and confirm the causative variant. A homozygous missense mutation in the SPART variant c.988A>G p.(Met330Val) was identified through molecular analysis. According to HGMD Professional 2021.1, this variant has previously been described as a disease-causing intellectual disability and Troyer syndrome.
Comparison of preemptive analgesic efficacy of tapentadol and tramadol on postoperative pain in patients of lumbar laminectomy
Authors: Gajbhare Manojkumar N , Mane Ajit A , Kamble Neha P 
Published: November 2023

Abstract

Background:
Preemptive analgesia is a treatment modality initiated before surgery as a part of multimodal analgesia for optimum treatment of postoperative pain. It accelerates the time to achieve recovery milestones, reduces the length of hospital stay, and improves patient satisfaction.

Materials and Methods:
It is a prospective, randomized, observational, cross-sectional study. Sixty patients posted for lumbar laminectomy were randomly assigned into two groups to receive tapentadol 100 mg (group A) or tramadol 100 mg (group B) orally 60 min before surgery. Intraoperative fentanyl and isoflurane requirement was recorded. Postoperatively, pain and sedation were assessed at 0, 2, 4, 6, 12, and 24 h; time of first analgesic requirement, paracetamol requirement, time to first rescue analgesia, number of patients requiring rescue analgesia, and morphine requirement were noted.

Results:
There was a significant reduction in the intraoperative isoflurane (P < 0.05) and fentanyl requirement (P 0.036). The mean postoperative pain scores at all-time points were less in group A compared with group B (P < 0.05), leading to a highly significant reduction in the mean paracetamol dose (P < 0.001) and time to first analgesic requirement (P = 0.047) in group A. The number of patients requiring rescue analgesia (P = 0.0098), time first to rescue analgesia (P = 0.048), and the mean rescue analgesic requirement (morphine) (P = 0.023) were less in group A compared with group B. The incidence of vomiting was significantly higher in group B (P = 0.0385).

Conclusion:
Tapentadol is more effective preemptive analgesia than tramadol and has a better side effect profile.
Individualização do tratamento com topiramato em pacientes infantis com epilepsia focal
Authors: Fernandes Inocencio Isabelle , Porto Nicoli Larissa , Vale Almeida Letícia , Carvalho de Lima Louise , Lucena Natália , Giorgetti Leandro 
Published: November 2023

O topiramato é um medicamento antiepilético utilizado em crises de epilepsia parciais em adultos e crianças, atuando no sistema nervoso central (SNC) e trazendo equilíbrio às células neurológicas. O estudo tem aplicação em pacientes infantis, em que são demonstrados os efeitos benéficos da individualização, principalmente por se tratar de um fraco indutor enzimático, como será exposto no decorrer deste artigo. O manuscrito tem o objetivo de demonstrar o comportamento do topiramato quando administrado de maneira individualizada no público infantil, tendo em vista a farmacogenética que visa entender a variabilidade genética de cada indivíduo no que diz respeito a medicamentos específicos, além de uma sucinta comparação com drogas antiepiléticas (DAEs) mais antigas e que ainda são utilizadas como medicamentos de primeira no tratamento de epilepsia parcial infantil. O estudo teve embasamento em pesquisas realizadas nas plataformas: Google Acadêmico, PubMed e Scielo. Na busca foram utilizadas palavras em inglês que se correlacionassem com o tema proposto e os artigos selecionados tiveram como critério de escolha a quantidade de vezes em que foram citados e o ano de publicação. Após as buscas, foram selecionados 32 artigos que compuseram a formação do estudo em questão, dentre eles artigos relacionados à epilepsia infantil parcial, ao topiramato e à farmacogenética. Em suma, entende-se que estudos com base na farmacogenética sejam mais disseminados no decorrer dos anos, para que possam existir tratamentos cada vez mais personalizados e individualizados aos pacientes portadores de epilepsia, principalmente no público infantil.
EFFORTS TO INCREASE TEACHER COMPETENCY IN TEACHING THROUGH THE USE OF THE MERDEKA TEACHING PLATFORM AT SDN PAKIS V SURABAYA ACADEMIC YEAR 2022/2023
Authors: Muhanik Irwan 
Published: November 2023

The implementation of the Independent Learning Curriculum is a major change in the education system in Indonesia. These changes not only affect classroom teaching methods, but also affect school structure and management systems. In this context, the role of the school principal becomes very important, especially in supervising the curriculum implementation process.
Principal supervision is very important in implementing the Independent Learning Curriculum for several reasons. Supervising the implementation of the Independent Learning Curriculum is not an easy task. A good understanding of this curriculum is required, as well as skills in supervision and school management. Therefore, it is important for school principals to continue to improve their competence in this matter.
This research was conducted using the school action research method which lasted for 2 cycles. Each cycle consists of planning, implementation, observation and reflection stages. The research method used by researchers is to carry out academic supervision which includes traditional supervision and clinical supervision with subj. 10 Class teachers and fields of study
The results of this research show that the implementation of the use of good practices in PMM through academic supervision in cycle 2 in the learning category is very good with a score of 4.2. With the results above, the implementation of the use of good practices in PMM through academic supervision is considered successful because the results are good and in accordance with the predetermined indicators of success in increasing teacher professionalism.
Effect of qualitatively varied reinforcement on response rates using substitutable consequences
Authors: Núñez-Santana Jesús Cuitláhuac 
Published: November 2023

In order to test the effects of qualitatively varied reinforcement on response rates 3 experiments were conducted. The goal of the first experiment was asses the level of substitutability between two reinforcers 8 female Wistar rats kept on a diet consisting solely of turnip and millet seeds, subjects were exposed to a concurrent FR5 FR5 and then to a FR4 FR8 program, by the end of the experiment there was a swift in consumption, albeit to a small degree. During the second experiment, 8 female Wistar Rats were exposed to a three-component variable interval program which consisted of three components; one during which only millet seeds were available, one in which only turnip seeds were available and a third component in which both kinds of seeds were delivered randomly. By the end of the experiment the highest response rates were recorded during the component in which only millet seeds were available. Finally, a Third experiment was implemented in order to assess whether the particular way in which the substitutable consequences are delivered (i.e., random or simultaneously) has an effect on response rates. The program for this experiment consisted of a VI 60`s with two components. During one of the components a mixture of millet seeds was delivered when subjects responded after the interval was reached while during the second component either millet and turnip seeds were delivered randomly. By the end of the experiment no differences between components were found. Results are discussed in terms of their implications for the study of reinforcement.