bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact on patients’ workload due to COVID-19 pandemic in a high volume radiodiagnosis department and its effect on health-care personnel of a tertiary care hospital in Bihar
Authors: Kumar Rajeev , Kumar Santosh , Kumar Arunav , Sakshi  , Jha Ashutosh , Ram Nain Kumar , Suman Sanjay Kumar 
Published: October 2023

Background:
The study aimed to estimate the effect of the COVID-19 pandemic on the amount of work and mental well-being of the employees. The front-line workers of the radiodiagnosis department incorporated remarkable stress, during caring for COVID-19-infected patients, which led to new encounters of work arrangements in the department.

Methodology:
The study was piloted from April 2019 to March 2022, to estimate the amount of work and mental well-being of health workers in the Department of Radiodiagnosis at Tertiary Health Care Hospital of North India. General Health Questionnaire-12 was applied to assess the mental well-being.

Results:
Health-care personnel, who faced COVID-19 patients, were subjected to more workload and mental stress compared to others. Radiological investigation requires a very close contact with the patients and due to high infectivity, morbidity, mortality, and no definite line of treatment, it causes unprecedented mental and physical stress to radiologist, radiographer, and hospital attendants, in comparison to the other investigations.

Conclusion:
Job nature, working hours, learning level, and close contact with COVID-19 patients, affected the adverse mental status of the members of the radiodiagnosis department. Radiographers and residents were under higher mental stress compared to others. We advocated that complete support should be delivered to support the well-being of health-care personnel. Front-line workers in the department of radiodiagnosis are supposed to be low stress and workload, but high work commitment.
Role of percutaneous CT-guided biopsy in the characterisation of pleural diseases
Authors: Pasha Iram , Singh Anil K. , Hashim Zia , Nath Alok , Neyaz Zafar , Mishra Richa , Agrawal Vinita 
Published: October 2023

Background:
Computed tomography (CT)-guided biopsy is emerging as a preferred and safe method for obtaining tissue samples in pleural diseases.

Objective:
This study aimed to evaluate the diagnostic yield and safety of percutaneous CT-guided biopsy in pleural diseases and to find CT findings predictive of malignant neoplastic pleural disease.

Material and Methods:
This retrospective study included 77 patients with pleural disease who underwent CT-guided pleural biopsies from July 2013 to May 2020. All procedures were performed with a coaxial semi-automatic biopsy device. Histopathology was performed in all cases, and additional tests such as immunohistochemistry (IHC) or microbiological analysis were carried out depending on clinical suspicion. The correlation of CT findings with final diagnosis was performed by Chi-square, Fisher's exact test and logistic regression analysis.

Results:
The overall technical success rate of CT-guided pleural biopsy was 100% with a diagnostic yield of 96.1%. No major complication was encountered, with minor complications encountered in the form of minimal pneumothorax and chest pain. Malignant pleural conditions constituted the largest group including metastatic adenocarcinoma as the most common (31.2%), followed by metastatic squamous cell carcinoma and mesothelioma. Tubercular pleural involvement was the second most common category (16.9%). The cartridge-based nucleic acid amplification test (CB-NAAT) assay had 90% sensitivity on pleural tissue in tubercular cases. CT features predictive of malignancy were irregular and nodular pleural thickening, mediastinal and diaphragmatic pleural involvement and mediastinal/chest wall invasion. There was a good correlation between higher pleural thicknesses with malignant outcome.

Conclusion:
Percutaneous CT-guided biopsy is a safe method for obtaining pleural tissue samples with high diagnostic yield. CT findings provide clues, which favour malignant pleural involvement.
Pre-extensively drug-resistant tuberculosis among pulmonary multidrug-resistant tuberculosis patients in Eastern Nigeria
Authors: Nwachukwu Ndubuisi O. , Ulasi Amara E. , Okoronkwo Christopher U. , Unegbu Valentine N. 
Published: October 2023

Background:
Pre-extensively drug-resistant tuberculosis (Pre-XDR-TB), an emerging form of drug-resistant tuberculosis, is challenging efforts at tuberculosis control, leading to treatment failure among multidrug-resistant tuberculosis (MDR-TB) patients and progression to extensively drug-resistant tuberculosis (XDR-TB). We determined the rate of Pre-XDR-TB among multidrug-resistant patients in Southeast, Nigeria.

Methods:
A prospective laboratory-based study was carried out at the South East Zonal Tuberculosis Reference Laboratory from January 2021 to December 2021. Second-line drug (SLD) resistance was performed on 225 sputum samples of multidrug-resistant patients prior to treatment initiation using GenoType MTBDRsl genotypic drug susceptibility testing (DST) method.

Results:
The rate of Pre-XDR-TB among 225 MDR-TB cases was 3.1%. Fluoroquinolone-resistant Pre-XDR-TB was observed (100%) in previously treated tuberculosis cases. Only one (0.4%) case showed resistance to both fluoroquinolone (FQ) and one second-line injectable drug (XDR-TB). The extensively drug-resistant case observed was a de-novo resistance. Exactly 0.9% of the multidrug-resistant cases showed resistance to second-line injectables.

Conclusion:
The prevalence of Pre-XDR-TB among MDR-TB cases was high. There is need for rapid detection of Pre-XDR-TB among MDR-TB cases before treatment initiation.
Lower bounds on Bourgain’s constant for harmonic measure
Authors: Badger Matthew , Genschaw Alyssa 
Published: October 2023

AbstractFor every
$n\geq 2$
, Bourgain’s constant
$b_n$
is the largest number such that the (upper) Hausdorff dimension of harmonic measure is at most
$n-b_n$
for every domain in
$\mathbb {R}^n$
on which harmonic measure is defined. Jones and Wolff (1988, Acta Mathematica 161, 131–144) proved that
$b_2=1$
. When
$n\geq 3$
, Bourgain (1987, Inventiones Mathematicae 87, 477–483) proved that
$b_n>0$
and Wolff (1995, Essays on Fourier analysis in honor of Elias M. Stein (Princeton, NJ, 1991), Princeton University Press, Princeton, NJ, 321–384) produced examples showing
$b_n<1$
. Refining Bourgain’s original outline, we prove that
$$\begin{align*}b_n\geq c\,n^{-2n(n-1)}/\ln(n),\end{align*}$$
for all
$n\geq 3$
, where
$c>0$
is a constant that is independent of n. We further estimate
$b_3\geq 1\times 10^{-15}$
and
$b_4\geq 2\times 10^{-26}$
.
ROLE OF OBESITY IN BREAST CANCER METASTASIS
Authors: Daraz Fadila Gustiani , Windarti Indri , Ayu Sangging Putu Ristyaning 
Published: October 2023

Kanker payudara adalah jenis kanker yang paling umum diderita wanita di seluruh dunia. Salah satu faktor yang diyakini memiliki peran dalam perkembangan dan pertumbuhan kanker payudara adalah status gizi yang dapat dihubungkan dengan indeks massa tubuh pasien dewasa. Diperkirakan bahwa berat badan berlebih dan obesitas menjadi salah satu faktor risiko penyebaran kanker payudara menjadi metastasis jauh. Mekanisme penyebaran melalui dua cara, estrogen dan leptin. Aromatase adalah enzim dalam biosintesis estrogen yang mendorong pertumbuhan tumor melalui ekspresinya dalam sel stroma adiposa payudara. Sedangkan, leptin dihasilkan oleh adiposit. Adiposit yang mengalami hipertrofi dan hiperplasia menyebabkan perubahan patofisiologi yang berpengaruh pada perkembangan kanker payudara. Berbagai studi kasus menunjukkan diet tinggi lemak dan kalori berkaitan dengan timbulnya kanker payudara. Tingginya risiko obesitas terhadap metastasis kanker payudara. ini penting untuk dikaji lebih lanjut karena banyaknya kasus kanker payudara baik secara global, di Indonesia maupun di Lampung. Artikel review ini penting untuk mengetahui hubungan obesitas dengan metastasis kanker payudara, sebagai informasi ilmiah dan pengetahuan, serta dapat dijadikan bahan intervensi diet pada pasien kanker payudara yang mengalami obesitas.
Pengaruh Harga terhadap Keputusan Pembelian Ice Cream (Studi Kasus di Mixue Yogyakarta)
Authors: Candra Rini Ika Tirta , Hartadi Agung 
Published: October 2023

Mixue is a drink outlet from China, which serves a variety of drink menus and also ice cream. This drink has so many branches spread across every provincial city and has quite a few fans, so the company must be really careful in setting prices that suit people's pockets. The aim of this research is to find out how influential price is on the decision to purchase Mixue products.
This research uses a quantitative research method where data is collected using a questionnaire distributed to 100 respondents who are consumers of ice cream mixue products. Data collection in this research was carried out by distributing questionnaires and then processing them using simple linear regression analysis, T test, and correlation coefficient test. Based on the research results, it shows that price influences the decision to purchase Ice Cream Mixue products. This can be seen from the significance value of 0.001 < 0.05.

Keywords: Price, Purchase Decision, Mixue products
METAVERSE VE METAVERSE’TE SÖZLEŞMELERİN KURULMASI
Authors: EKİCİ Şerafettin 
Published: October 2023

İnsanların sadece bakmak yerine içinde bulunduğu internet alemi olarak tarif edilen metaverse, web 3.0’ın sunduğu yeni ve son nesil internet sürümü olarak karşımıza çıkmakta ve genellikle bilgisayar tarafından zaman ve mekânsal gerçekliğin dışında oluşturulmuş, üç boyutlu sanal (dijital) evren olarak tanımlanmaktadır.

İlk defa Neal Stephenson tarafından 1992 yılında yazılan “Snow Crash” adlı bilim-kurgu romanıyla literatürde yerini alan Metaverse kavramı, bilim ve teknolojide yaşanan ve bilişim çağını ortaya çıkaran gelişmelerin bir devamı olarak değerlendirilmektedir.

Günümüzde henüz tek bir Metaverse yoktur; bunun yerine birbirinden bağımsız ve birbiri ile uyumlaştırılmamış durumdaki dApp’ler yani sanal dünya uygulamaları bulunmaktadır. Ancak hem Metaverse’e yatırım yapan büyük şirketlerin, hem Metaverse tasarımcılarının, hem de bu konuda çalışma yapan araştırmacıların nihaî hedef ve vizyonu; birbiri ile eş güdüm içerisinde ve birlikte çalışan dApp’lerden oluşan, kullanıcıların istedikleri ortamda rahatça gezinebildikleri, tek bir sanal para biriminin kullanıldığı yahut farklı dApp’lere ait sanal para birimlerinin birbiri ile karşılıklı değiştirilebildiği, insanların iletişim, sosyalleşme, yatırım, iş kurma, alışveriş, rehberlik ve turizm gibi faaliyetleri yerine getirebildiği tek bir Metaverse oluşturmaktır. Bu kapsamda birçok büyük şirket Metaverse ortamına yatırım yapmış ve bazıları şimdiden Metaverse mağazalarını açmıştır.

Metaverse ile birlikte birçok geleneksel iş dalı sona erecek, buna karşılık birçok yeni iş dalı, meslek ve uzmanlık alanı ortaya çıkacaktır.
Türk Borçlar Kanunu’nda (TBK) geçerli olan sözleşme serbestisi ilkesi ve bu ilkenin tüm sınırları aksi yönde herhangi bir yasal düzenleme olmadığı müddetçe Metaverse’te yapılan sözleşmeler için de geçerli kabul edilmelidir.

TBK’nın 4/2. Maddesi uyarınca, Metaverse’te gerçekleştirilen doğrudan iletişim esnasında yapılan sözleşmeler, hazırlar arasında yapılmış bir sözleşme sayılmalı ve hazırlar arasındaki sözleşmelere dair hükümler uygulama alanı bulmalıdır.

Metaverse’te fizîken gerçek kişiler yerine avatarları bulunmaktadır. Avatarlar bizzat bunların sahipleri ya da kullanıcıları tarafından yönetilmekte ve yönlendirilmektedir. Avatarın ayrı bir kişiliği, hak ehliyeti, iradesi, fiil ehliyeti yoktur. Bu nedenlerle, avatarlar tarafından beyan edilen iradeler avatarın sahibi ya da kullanıcısına ait kabul edilmeli, hukukî ve cezaî hak ve sorumluluklar da bu kişiye yüklenmelidir.

Bu makalede, Metaverse hakkında yurt içi ve yurt dışında yazılmış olan kitap, makale ve raporlar üzerinde inceleme yapılmış, Metaverse’ün tanımı, özellikleri, tarihi gelişimi ve iktisadî hayata beklenen katkıları ortaya konulmuş, ayrıca yürürlükteki Türk hukuku kapsamında Metaverse’te sözleşmelerin kurulması, Metaverse’te kurulan sözleşmelerin Türk hukukunda yer alan geçersizlik halleri, irade beyanlarının sağlığı ve genel işlem koşulları açısından incelemesi yapılarak, bu konuların Metaverse’te nasıl şekil bulacağı ve nasıl yorumlanması gerektiği ortaya konulmuştur.
Os gêneros textuais na educação de jovens e adultos
Authors: Cruz Francisca da Silva , Rios Ofliza Vieira da Silva 
Published: October 2023

Desenvolver a leitura e produção textual entre os alunos da Educação de Jovens e Adultos é um desafio que os professores de Língua Portuguesa enfrentam em virtude das particularidades que essa modalidade de ensino apresenta. Nesse sentido, o presente trabalho apresenta como objetivo analisar os gêneros textuais como instrumentos para o processo de aprendizagem da leitura e escrita entre os alunos da Educação de Jovens e Adultos-EJA. A Educação de Jovens e Adultos é a modalidade de ensino que atende os alunos jovens e adultos que não concluíram a educação básica na idade própria. Esses alunos possuem suas particularidades e conhecimentos que já adquiriram ao longo da vida e que devem ser considerados quando se trata do processo de ensino e aprendizagem. Os gêneros textuais que circulam no cotidiano dos alunos podem ser uma ferramenta a mais para a aquisição da competência de leitura e escrita dos alunos da EJA. Para a fundamentação teórica sobre leitura e gêneros textuais, as discussões foram fundamentadas nas concepções de Solé (1998), Cagliari (2009), Kleiman (2002, 2005), Kock (2007), Marcuschi (2005,2010), Bakhtin (2003, 2016); Foucault (1996, 2008); para fundamentação sobre Educação de Jovens e Adultos, as discussões se apoiam em Freire (1989, 1992), Paiva (2003), entre outros. A metodologia utilizada para a construção deste trabalho foi a pesquisa bibliográfica.
Análise bibliométrica sobre efluentes cadavéricos como fonte potencialmente poluidora do meio ambiente
Authors: Martins Rafael Faustino , Rigolin Luigi Cruzal , Shimano Marcos Massao , Dantas Sandra Cristina , Silva Priscila Pereira 
Published: October 2023

Ao fim da vida, o corpo passa por um processo natural de decomposição onde sua matéria é transformada por bactérias e enzimas em sais, líquidos e gases. Esses efluentes da decomposição cadavérica são potenciais poluidores do meio ambiente que acabam transformando os cemitérios em centros de contaminação constante através de mudanças biológicas, físicas e químicas ao solo, ar e principalmente os recursos hídricos próximos. Estudos bibliométricos fornecem um meio útil para rastrear as pesquisas e tendências em uma determinada área. Para isso, foi realizado um estudo bibliométrico das publicações sobre esse tema publicadas na última década disponíveis nos bancos de dados Web of Science e Scopus. A partir dos trabalhos abordados é possível compreender como a contaminação dos efluentes cadavéricos ocorre, através da retenção e tratamento desses resíduos é possível contornar esse problema, sendo os cemitérios verticais os mais indicados pois facilitam a coleta dos efluentes. Soluções viáveis e ambientalmente corretas são necessárias para que novas propostas sejam levantadas, deixando aberta a possibilidade da utilização dos efluentes cadavéricos coletados. A conscientização da população acerca dos riscos perante a saúde pública que os cemitérios representam mostra-se essencial, para que possam exigir dos governantes o compromisso com o Meio Ambiente.
A percepção dos “facilitadores” acerca da Política Nacional de Educação Permanente em Saúde e sua aplicabilidade em um hospital público no Pará
Authors: Maués Victor Matheus Silva , Moraes Pilar Maria de Oliveira , De Souza Carlos Jefferson Santana , E Silva Luciana Tábatha Souza , Bemerguy Saul Falcão Bemerguy , Da Rocha Nathaska Lorrana Santiago , Monteiro Camila Negrão , Araújo Lia Crystina Bastos , De Vilhena Marcelo Silva , Carrera Hanna Ariane Monteiro , Trindade Creusa Barbosa dos Santos 
Published: October 2023

O presente estudo teve como objetivo discutir o processo de execução da Política Nacional de Educação Permanente em Saúde – PNEPS desenvolvido pelos facilitadores de conhecimentos da FSCMPA e investigar o entendimento dos facilitadores acerca dos conceitos didático-pedagógicos que influênciam em sua prática. Tratou-se de um estudo descritivo, exploratório, com abordagem quanti-qualitativa. Foi desenvolvido na Fundação Santa Casa de Misericórdia do Pará, que é um hospital de ensino reconhecido por meio da portaria interministerial MS/MEC nº2378 de 26 de outubro de 2004. O grupo de profissionais de saúde envolvidos na investigação, foi composto por 08 servidores cadastrados no projeto “Facilitadores” promovido pela GEDP. A coleta de dados foi realizada entre junho e agosto de 2023, por meio de um Forms com perguntas abertas e fechadas, a fim de promover uma discussão acerca da matriz de planejamento e organização do processo de educação permanente. O estudo obteve o núcleo temático: percepção dos profissionais acerca das metodologias ativas de ensino-aprendizagem na formação em saúde. dando origem a dois núcleos temáticos: 1) Conhecimento acerca da Política Nacional de Educação Permanente em Saúde – PNEPS, pelos profissionais de saúde; 2) Aplicabilidade das metodologias ativas de ensino-aprendizagem no campo da saúde. Grande parte dos profissionais relacionarm a EPS com a aprendizagem de forma prática, aperfeiçoamento e qualificação do processo educacional e prática de trabalho. Contudo, apesar das práticas serem fortalecidas na instituição, ainda se encontra dificuldade por parte dos profissionais, no que diz repeito a organização, planejamento e financiamento dos projetos, sendo assim, o potencial da equipe de saúde é pouco explorado. Dessa forma, é necessário que pactos sejam fortalecidos no quesito de estimular a capacidade criativa dos profissionais de saúde, articulando e impulsionando os saberes e novos fazeres nos serviços de saúde.
Tecnologias educacionais sobre saúde sexual e reprodutiva de adolescentes escolares: revisão integrativa
Authors: De Almeida Thayse Gomes , Cabral Ivens Bruno Vieira , Trindade Ruth França Cizino , De Oliveira Sheyla Costa , Aquino Priscila de Souza , Guedes Tatiane Gomes 
Published: October 2023

A adolescência é a fase de transição entre a infância e a idade adulta, onde a sexualidade desempenha um papel crucial na formação da identidade dos adolescentes, através da expressão dos desejos e atração sexual. Utilizar tecnologias educacionais para promover a saúde entre adolescentes visa capacitar e empoderá-los na sua saúde. Este estudo objetivou analisar tecnologias educacionais utilizadas para abordagem da saúde sexual e reprodutiva de adolescentes nos espaços escolares. Trata-se de uma revisão integrativa da literatura, com busca realizada entre dezembro de 2022 e março de 2023 nas bases de dados: LILACS, Pubmed/MEDLINE, CINAHL, Embase, Web of Science e Scopus. Foram extraídas das bases um total de 960 publicações, contudo, ao final, 17 produções foram incluídas. Identificou-se uma diversidade de tecnologias educacionais utilizadas na saúde sexual e reprodutiva de adolescentes. A tecnologia mais prevalente foi o jogo, seguido por programas online/sites e teatro/dramatização. Vídeos, paródias, aplicativos e cartilha foram utilizados em uma publicação cada. O estudo apresenta evidências de práticas inovadoras para a educação sexual e reprodutiva direcionada a adolescentes nos espaços escolares, possibilitando aprendizado mais efetivo, dinâmico e eficiente.
Mediation in Criminal Proceedings in Kazakhstan and Foreign Countries: Comparative Legal Analysis
Authors: Baimukhametova Guldana , Baikenzhina Kulbagila , Momysheva Farkhiya , Veselskaya Natalya , Ospanova Zhuldyz , Chingaeva Baktygul 
Published: October 2023

Objective: the purpose of this study is to consider the essence of mediation in criminal proceedings and determine its characteristics in the foreign legal system to improve national legislation.

Theoretical framework: theoretical materials were based on international scientific publications, reports, and scientific papers. And also for a more complete and objective presentation of the problem being studied, practical materials from criminal cases were used.

Method: is a dialectical method of understanding general patterns and particular manifestations of the essence of phenomena of objective reality. The comparative legal method made it possible to qualitatively study foreign legislation from the point of view of legal regulation of mediation in criminal proceedings, especially the experience of France, and in this regard, implement it into national legislation. The logical method made it possible to analyze the mechanism for implementing mediation in criminal proceedings and identify its components that need improvement.

Results and conclusion: mediation relieves the parties from the formal procedures inherent in judicial proceedings, from coercion, without which the exercise of judicial power is unthinkable. The personal participation of the parties in resolving the dispute, their joint search for a way out of the conflict, awareness of the need to find a mutually acceptable condition within the framework of law while respecting the legitimate interests of each party allows them to appreciate the meaning and significance of the law in their everyday life, provides experience in lawful behavior and a legal way out of conflict situations.

Originality/value: the value of the study lies in the fact that, on the basis of theoretical and legal analysis and the study of practical experience, it seems possible to improve the mechanism for implementing mediation in criminal proceedings in national legislation.
CORRELATION BETWEEN INTRAHEPATIC cccDNA AND SERUM HBV pgRNA IN TREATMENT-NAÏVE CHRONIC HEPATITIS B PATIENTS
Authors: Đỗ Thị Lệ Quyên , Ho Huu Tho , Nguyen Dinh Ung , Hoang Tien Tuyen 
Published: October 2023

Objectives: To evaluate the correlation between intrahepatic covalently closed circular DNA (cccDNA) and serum HBV pregenomic Ribo nucleic acid (pgRNA) in treatment-naïve chronic hepatitis B (CHB) patients. Methods: A total of 105 treatment-naïve CHB patients from the Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, were enrolled from 2017 to 2020. Real-time RT-PCR methods were used to quantify serum HBV pgRNA and intrahepatic cccDNA. Clinical and histopathological assessments were also performed. The patients were categorized into two groups: HBeAg-positive CHB (n = 59) and HBeAg-negative CHB (n = 46). Statistical analyses were conducted using Medcalc 20.019. Results: In treatment-naïve patients, the average concentration of cccDNA and HBV RNA were 1.61 ± 0.40 log10 copies/cell and 4.88 ± 1.65 log10 copies/mL, respectively. A positive linear correlation was observed between HBV pgRNA and cccDNA, especially in the overall group and the HBeAg-negative subgroup, as well as in patients with HAI score ≥ 9 and Fibrosis score ≥ 3 (r = 0.49, r = 0.56, and r = 0.57; p < 0.01, respectively). Conclusion: The study findings indicate a positive linear correlation between intrahepatic cccDNA and serum HBV pgRNA in CHB patients. HBV pgRNA can serve as a reliable marker in the management of CHB patients.
SURGICAL TREATMENT OF ATYPICAL MYOMATOSIC NODES IN REPRODUCTIVE AGE. COMPLICATIONS ARISING FROM A CLINICAL CASE
Authors: Григорьянц Армен Александрович 
Published: October 2023

Хирургическое лечение больных с атипичным расположением узлов миомы матки относится к категории травматичных, технически сложных операций и имеет высокий риск интра и послеоперационных осложнений. Осложнения в послеоперационном периоде в любом их проявлении могут повлечь стойкое ухудшение качества жизни в отдаленном периоде
Surgical treatment of patients with atypical locations of uterine fibroid nodes falls into the category of traumatic, technically complex operations and has a high risk of intra and postoperative complications. Complications in the postoperative period in any of their manifestations can lead to a persistent deterioration in the quality of life in the long term