bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment and comparative genomics of a high-quality collection of mosquito-associated bacterial isolates - MosAIC (Mosquito-Associated Isolate Collection)
Authors: Foo Aidan , Brettell Laura E. , Nichols Holly L. ,   2022 UW-Madison Capstone in Microbiology Students, Medina Muñoz Miguel , Lysne Jessica A. , Dhokiya Vishaal , Hoque Ananya Ferdous , Brackney Doug E. , Caragata Eric P. , Hutchinson Michael , Jacobs-Lorena Marcelo , Lampe David J. , Martin Edwige , Valiente Moro Claire , Povelones Michael , Short Sarah M. , Steven Blaire , Xu Jiannong , Paustian Timothy D. , Rondon Michelle R. , Hughes Grant L. , Coon Kerri L. , Heinz Eva 
Published: October 2023

AbstractMosquitoes transmit medically important human pathogens, including viruses like dengue virus and parasites such asPlasmodiumspp., the causative agent of malaria. Mosquito microbiomes are critically important for the ability of mosquitoes to transmit disease-causing agents. However, while large collections of bacterial isolates and genomic data exist for vertebrate microbiomes, the vast majority of work in mosquitoes to date is based on 16S rRNA gene amplicon data that provides limited taxonomic resolution and no functional information. To address this gap and facilitate future studies using experimental microbiome manipulations, we generated a bacterialMosquito-Associated IsolateCollection (MosAIC) consisting of 392 bacterial isolates with extensive metadata and high-quality draft genome assemblies that are publicly available for use by the scientific community. MosAIC encompasses 142 species spanning 29 bacterial families, with members of theEnterobacteriaceaecomprising 40% of the collection. Phylogenomic analysis of three genera,Enterobacter, Serratia, andElizabethkingia, reveal lineages of mosquito-associated bacteria isolated from different mosquito species in multiple laboratories. Investigation into species’ pangenomes further reveals clusters of genes specific to these lineages, which are of interest for future work to identify functions underlying mosquito host association. Altogether, we describe the generation of a physical collection of mosquito-associated bacterial isolates, their genomic data, and analyses of selected groups in context of genome data from closely related isolates, providing a unique, highly valuable resource to investigate factors for bacterial colonisation and adaptation within mosquito hosts. Future efforts will expand the collection to include broader geographic and host species representation, especially from individuals collected from field populations, as well as other mosquito-associated microbes, including fungi, archaea, and protozoa.
Molecular logic of neuromodulatory systems in the zebrafish telencephalon
Authors: Anneser Lukas , Satou Chie , Hotz Hans-Rudolf , Friedrich Rainer W. 
Published: October 2023

AbstractThe function of neuronal networks is determined not only by synaptic connectivity but also by neuromodulatory systems that broadcast information via distributed connections and volume transmission. To understand the molecular constraints that organize neuromodulatory signaling in the telencephalon of adult zebrafish we used transcriptomics and additional approaches to delineate cell types, to determine their phylogenetic conservation, and to map the expression of marker genes at high granularity. The combinatorial expression of GPCRs and cell type markers indicates that all neuronal cell types are subject to modulation by multiple monoaminergic systems and distinct combinations of neuropeptides. Individual cell types were associated with multiple (typically >30) neuromodulatory signaling networks but expressed only a few diagnostic GPCRs at high levels, suggesting that different neuromodulatory systems act in combination albeit with unequal weights. These results provide a detailed map of cell types and brain areas in the zebrafish telencephalon, identify core components of neuromodulatory networks, highlight the cell type-specificity of neuropeptides and GPCRs, and begin to decipher the logic of combinatorial neuromodulation.
Compression of morbidity by interventions that steepen the survival curve
Authors: Yang Yifan , Mayo Avi , Levy Tomer , Raz Naveh , Jarosz Dan , Alon Uri 
Published: October 2023

AbstractLongevity research aims to extend the period of healthy life, known as the healthspan, and to minimize the duration of disability and morbidity, known as the sickspan. Most longevity interventions in model organisms extend healthspan, but it is not known whether they extend healthspan relative to the lifespan - that is, whether they compress relative sickspan. Here, we present a theory that predicts which interventions effectively compress relative sickspan. The theory is based on the shape of the survival curve - the fraction of organisms surviving as a function of age. Interventions that extend mean lifespan while preserving the shape of the survival curve, known as scaling, are predicted to extend the sickspan proportionally, without compressing it. Such interventions include caloric restriction and many other longevity interventions. Conversely, a small subset of interventions that extend lifespan and steepen the shape of the survival curve, are predicted to compress the relative sickspan. We explain this based on the saturating removal mathematical model of aging, and present evidence from longitudinal health data in mice,Caenorhabditis elegansandDrosophila melanogaster. We discuss longevity interventions in mice that steepen the survival curves, including senolytics, ketogenic diet, and agents that reduce glucose spikes and protect blood vessels, as potential candidates for compressing the sickspan. We apply the theory to combinations of longevity interventions and discuss human healthspan data. This approach offers potential strategies for compressing morbidity and extending healthspan.
Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers
Authors: Trouilleton Quentin Durieux , Housset Dominique , Arragain Benoît , Malet Hélène 
Published: October 2023

ABSTRACTHantaan virus is a dangerous human pathogen whose segmented negative-stranded RNA genome is replicated and transcribed by a virally-encoded multi-functional polymerase. Here we describe the complete cryo-electron microscopy structure of Hantaan virus polymerase in several oligomeric forms. Apo polymerase protomers can adopt two drastically different conformations, which assemble into two distinct homodimers, that can themselves gather to form hexamers.Polymerase dimerization induces the stabilization of most polymerase domains, including the C-terminal region that notably contains a C-terminal domain that contribute the most to dimer’s interface, along with a lariat region that participates to the polymerase steadying.Binding to viral RNA induces significant conformational changes resulting in oligomer disruption, suggesting the possible involvement of multimers as protecting systems that would stabilize the otherwise flexible C-terminal domains.Overall, these results provide new insights into the multimerization capability of Hantavirus polymerase and may help to define antiviral compounds to counteract these life-threatening viruses.
Structure-Function Coupling in Highly Sampled Individual Brains
Authors: Rajesh Aishwarya , Seider Nicole A. , Newbold Dillan J. , Adeyemo Babatunde , Marek Scott , Greene Deanna J. , Snyder Abraham Z , Shimony Joshua S. , Laumann Timothy O , Dosenbach Nico U.F. , Gordon Evan M. 
Published: October 2023

ABSTRACTStructural connections (SC) between distant regions of the brain support synchronized function known as functional connectivity (FC) and give rise to the large-scale brain networks that enable cognition and behavior. Understanding how SC enables FC is important to understand how injuries to structural connections may alter brain function and cognition. Previous work evaluating whole-brain SC-FC relationships showed that SC explained FC well in unimodal visual and motor areas, but only weakly in association areas, suggesting a unimodal-heteromodal gradient organization of SC-FC coupling. However, this work was conducted in group-averaged SC/FC data. Thus, it could not account for inter-individual variability in the locations of cortical areas and white matter tracts. We evaluated the correspondence of SC and FC within three highly sampled healthy participants. For each participant, we collected 78 minutes of diffusion-weighted MRI for SC and 360 minutes of resting state fMRI for FC. We found that FC was best explained by SC in visual and motor systems, as well as in anterior and posterior cingulate regions. A unimodal-to-heteromodal gradient could not fully explain SC-FC coupling. We conclude that the SC-FC coupling of the anterior-posterior cingulate circuit is more similar to unimodal areas than to heteromodal areas.SIGNIFICANCE STATEMENTStructural connections between distant regions of the human brain support networked function that enables cognition and behavior. Improving our understanding of how structure enables function could allow better insight into how brain disconnection injuries impair brain function.Previous work using neuroimaging suggested that structure-function relationships vary systematically across the brain, with structure better explaining function in basic visual/motor areas than in higher-order areas. However, this work was conducted in group-averaged data, which may obscure details of individual-specific structure-function relationships.Using individual-specific densely sampled neuroimaging data, we found that in addition to visual/motor regions, structure strongly predicts function in specific circuits of the higher-order cingulate gyrus. The cingulate’s structure-function relationship suggests that its organization may be unique among higher-order cortical regions.
Repetitive transcranial magnetic stimulation implementation within residential substance use disorder treatment centers for patients with comorbid depression
Authors: Shenasa Mohammad Ali , Soltani Maryam , Tang Victor , Weissman Cory R. , Appelbaum Lawrence Gregory , Daskalakis Zafiris J. , Ramanathan Dhakshin 
Published: October 2023

Purpose
Repetitive transcranial magnetic stimulation (rTMS) is a well-established treatment with efficacy for several psychiatric disorders and has yielded promising yet mixed data showing reductions in craving for substance use. Patients with substance use disorders and comorbid depression may encounter obstacles to receiving rTMS in outpatient settings for treatment of depression. In turn, implementation of rTMS in residential substance use programs would greatly benefit those with comorbid treatment resistant depression. This paper aims to provide recommendations for implementing rTMS within residential substance use treatment centers.

Design/methodology/approach
Using PubMed, the authors conducted a narrative review of manuscripts using various combinations of the following search terms: rTMS, depression, substance use and substance use disorder. The authors read manuscripts for their methodology, outcomes and adverse events to synthesize their results, which correspond to their recommendations for patient selection, safely implementing rTMS in residential substance use facilities and optimal rTMS protocols to start with.

Findings
Advantages of this approach include increased compliance, monitoring and access to care. Recommendations to safely incorporate rTMS in residential substance use disorder treatment centers revolve around selection of patients eligible for rTMS, allowing for sufficient time to elapse prior to commencing rTMS, monitoring for signs of recent substance use or withdrawal and using rTMS protocols compatible with the therapeutic programming of a treatment center.

Originality/value
This paper details the challenges and benefits of implementing rTMS for patients with dual diagnosis and provides recommendations to safely do so. To the best of the authors’ knowledge, this is a novel and unpublished endeavor.
Consumers' sensory perception and technological properties of whole foods utilization in bakery products: a case of study of banana peel
Authors: Maschio Gabriel , Stoll Liana , Padilha Rosiele Lappe , de Moraes Kelly , Leães Fernanda Leal , Thys Roberta Cruz Silveira , Sant'Anna Voltaire 
Published: October 2023

PurposeThe objective was to evaluate the effect of banana peel into cake (a bakery product that may add bananas) and panettone (a product that never is added to bananas) formulations on consumers' acceptance and perceived attributes and the effect on the technological properties of the product.Design/methodology/approachBakery products were produced with banana peel in the formulation and control samples without residue. Volunteers scored their acceptance and checked all attributes applied to the four samples in the blind and informed tests. The texture, color, proximate composition and bake properties were measured.FindingsThe acceptance of both cakes, with and without banana peel, was not affected when consumers were informed that there was a residue in both cakes. Relative risk indicated that information had no influence on acceptance. Panettone with banana pulp showed a reduction in acceptance when volunteers were informed of the presence of banana peel. Risk analysis showed a significant relative risk of product rejection when consumers were aware of information. The addition of banana peel enhanced panettone chewiness and crumb hardness, reduced bake loss of cakes, reduced the volume of both products and changed some color parameters of both products.Originality/valueBanana peel is a source of functional compounds, but it is not clear how consumers react when informed that the food presents it.
An exploratory study on career models and mechanisms of career advancement of Emirati women managers
Authors: Al Imam Lama , Pinto Luisa Helena 
Published: October 2023

PurposeThis study uses a Kaleidoscope Career (KC) approach to explore how UAE women managers experience their careers, the advancement in management and the career models they encounter.Design/methodology/approachThis study employs an interpretative phenomenological approach to analyse in-depth face-to-face interviews with 22 Emirati women in middle and senior management positions across various industries in both the public and private sectors.FindingsThis research is significant in uncovering career advancement mechanisms and three career models: “my life is not elsewhere,” “seizing opportunities” and “wholehearted dedication to the country.” These models highlight women managers' pivotal role in UAE's economic development.Research limitations/implicationsThis study is confined to a convenience sample of women managers from Abu Dhabi, Dubai and Sharjah. While not fully representative of all local women, the findings on career advancement mechanisms and Emirati women managers' non-traditional career paths hold theoretical significance. The results challenge the uncritical adoption of Western career models, highlighting the need to consider alternative career models and advancement mechanisms.Practical implicationsThis research expands the authors' knowledge of career advancement mechanisms and models experienced by Emirati women, offering insights for enhancing gender equality in Arab world managerial roles.Originality/valueThese findings open new research avenues to explore Emirati women's careers beyond the largest Emirates and assess their broader economic and societal contributions.
The current research landscape in digital marketing scientific literature in libraries: exploration through performance and science mapping
Authors: Wani Javaid Ahmad 
Published: October 2023

Purpose
This study aims to analyse and understand the current state of research in the field of digital marketing in “library and information science”.

Design/methodology/approach
This study used a “bibliometric research design.” A lexical title search was used to obtain the required data set for executing this study, and a comprehensive “indexing and abstracting” database, Web of Science, was used as a data harvesting source. Louvain’s clustering algorithm was used for network metrics.

Findings
The findings revealed that research productivity and impact have grown considerably over time, indicating significant attention towards digital marketing research in library and information science (LIS). Moreover, the results showed that the overall author collaboration patterns were weak, hence creating room for development in the author’s collaboration patterns.

Practical implications
The current study could be very beneficial in providing a comprehensive and up-to-date overview of the “digital marketing” research field scholarly output in LIS, which can be used by researchers, practitioners and policymakers to guide their work and make informed decisions.

Originality/value
The originality of this bibliometric study lies in its comprehensive and up-to-date analysis of the current state of research in the field of “digital marketing” in LIS. This study provides a unique and in-depth understanding of the key authors, venues and papers in the field, as well as the trends and patterns in the research.
The reproduction of vulnerability: the incarceration and homelessness transcript for the Disasters: Deconstructed livestream on 31 March 2022
Authors: Álvarez Zulema , Bauman Tristia , Dominick Amite , Messenger Tony , Purdam Carlee , Vickery Jamie 
Published: October 2023

PurposeThis conversation focuses on the reproduction of vulnerability incarceration and homelessness and presents the reflections of scholars, writers, activists and practitioners.Design/methodology/approachThis paper is based on the conversations that took place on Disasters: Deconstructed Podcast livestream on the 31st of March 2022.FindingsThe prominent themes in this conversation include homelessness, incarceration, stigma and marginalisation.Originality/valueThe conversation contributes to the ongoing discussions around the reproduction of vulnerability and the importance of understanding its root causes of disaster scholarship, practice and activism.
Understanding client satisfaction of prefabricated curtain wall in Hong Kong using XGBoost and Pearson correlation
Authors: Kwok Tai Wai , Chang SiWei , Li Heng 
Published: October 2023

PurposeThe unitized curtain wall system (UCWS), a symbol of modern architecture, is gaining popularity among prefabricated components. Previous studies have focused on both construction technology advances and material selection strategies to facilitate the UCWS. However, the topic of client satisfaction, which drives industry development by targeting clients' demands, has gone unnoticed. Therefore, the current study aims to investigate client satisfaction with UCWS products in Hong Kong by finding its influential factors.Design/methodology/approachA systematic review was employed to first identify the influential factors. A semi-structured interview was employed to validate the reliability of the extracted factors. The machine learning algorithm Extreme Gradient Boosting (XGBoost) and the Pearson correlation were then employed to rank the importance and correlation of factors based on the 1–5 Likert scale scores obtained through a questionnaire survey.FindingsThe findings revealed that “reduction in construction time” and “reduction in construction waste” are the most important factors and have a strong positive influence on client satisfaction.Originality/valueUnlike previous studies, the present study focused on a novel research topic and introduces an objective analysis process using machine learning algorithms. The findings contribute to narrowing the knowledge gap regarding client preference for UCWS products from both individual and collaborative perspectives, providing decision-makers with an objective, quantitative and thorough reference before making investments in the curtain wall management development.
The factors impacting on the travel experience of a vegan lifestyle
Authors: Ottenbacher Michael , Busam Simone , Harrington Robert James , Allhoff Joachim 
Published: October 2023

PurposeThis study aims to examine the factors of the vegan lifestyle on the travel experience. Special emphasis was placed on difficulties during travel and influencing factors for destination choice.Design/methodology/approachThe vegan lifestyle has emerged as a growing market. The dietary reference is well-known, but the impact of the vegan lifestyle on tourism has received less attention. Earlier researchers have cited motivations of ethics, the environment and health as key. An online survey was conducted within the target group of vegans to provide more understanding of vegan tourism.FindingsA few participants stated that they refused to visit countries due to too high meat consumption or due to long flight distances. Nature was named as the most decisive factor for choosing a travel destination among the respondents. Problems that might arise were mainly the general lack of awareness about veganism, as well as the confusion between vegetarianism and veganism in the destinations. Most respondents indicated that these problems were generally prepared for during the pre-planning process.Research limitations/implicationsResearch on vegan tourism is a relatively unexplored niche topic, the study used related topics adapted to a vegan tourism context.Practical implicationsEnhanced education about veganism among tourism service providers would be desirable to counteract such problems in the future and make the travel experience more carefree for vegans.Originality/valueThere has been little research in the field of vegan tourism, thus, this study provides valuable information on the needs and challenges of this growing market.
Authentic passion matters: the role of emotional labor between presenters' passion and investment decision
Authors: Singh Sheetal , Kang Jae Hyeung , Ramani Ravi S. 
Published: October 2023

PurposeDrawing from affect as social information (AASI) theory, this study examines how the relationship between perceived passion, quality of the presenter and investment intention is influenced by emotional labor engaged in by the presenter. This study clarifies and deepens the understanding of how passion influences entrepreneurial success by studying the role of emotional labor in the relationship between passion and investment decisions.Design/methodology/approachThis study tested the moderated mediation effects between perceived presenter passion and investor intention to invest using data from 62 presenters' and 169 judges' responses from the 31 judges during a business plan (or “pitch”) competition.FindingsResults confirmed a positive indirect effect of perceived passion on intention to invest, as mediated by the investor's evaluation of the quality of the presenter. Emotional labor moderated the relationship such that low levels of emotional labor engaged in by the presenters strengthened the mediated relationship between perceived passion, quality of the presenter and intention to invest.Originality/valueThe findings suggest that the authenticity of passion (as measured by the degree of emotional labor engaged in by the presenter) influences this dynamic, such that displays of passion that are perceived as being authentic are more likely to lead to an investment decision. Using AASI, this study conceptualized and tested quality of the presenter as an important intervening variable that can help explain the lack of coherent findings. The results supported this conceptualization, providing empirical evidence for the oft-quoted adage “invest in people, not ideas.”