bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the Descaling Rate of an In-situ Ultrasonic Fouling Removal Method for Industrial Water-filled Pipelines
Authors: Mohammadi Aminollah , Mobli Mohamadhassan , Siahtiri Saeed , Karbasioon Amirreza , Tehrani Alireza Fadaei 
Published: October 2023

Abstract
Introducing innovative and environmentally friendly fouling removal methods for water-filled pipelines is essential nowadays to increase pipelines' safety and productivity and eliminate the limitations of traditional descaling methods. In this paper, we investigate the capability of high-power ultrasonic waves and cavitation phenomenon as an influential online fouling removal tool to remove the build-up fouling with a thickness of 1 mm on the inner surface of 4-inch low-carbon stainless steel pipes filled with water. First, we developed a FEM simulation to investigate the effect of ultrasonic power on the acoustic pressure at different distances from the transducer attached point on the pipe using Comsol Multiphysics. After that, we conducted an experimental and statistical investigation to validate our result from FEM analysis using a transducer set and PZT-4 piezoelectric attached to the pipes' outer surface. The results showed that increasing the transducer's electrical power would raise the fluid's acoustic pressure. Furthermore, we indicate that increasing the electrical power to 400 W results in a higher fouling removal rate in the pipe.
Genome-wide identification and expression analysis of the KCS gene family in soybean reveal their potential roles in response to abiotic stress
Authors: Gong Yujie , Wang Deying , Xie Haojie , Zhao Zewei , Chen Yuyue , Zhang Dongxue , Jiao Yexuan , Yang Jing , Guo Shangjing , Chu Pengfei , Sun Yongwang 
Published: October 2023

Abstract
Background: Very long chain fatty acids (VLCFAs) are fatty acids with chain lengths of 20 or more carbon atoms, which are the building blocks of various lipids that regulate developmental processes and plant stress responses. 3-ketoacyl-CoA synthase encoded by the KCS gene is the key rate-limiting enzyme in VLCFA biosynthesis, but the KCS gene family in soybean (Glycine max) has not been adequately studied thus far.
Results: In this study, 31 KCS genes (namely GmKCS1 - GmKCS31) were identified in the soybean genome, which are unevenly distributed on 14 chromosomes. These GmKCS genes could be phylogenetically classified into 7 groups. A total of 27 paralogous GmKCS gene pairs were identified with their Ka/Ks ratios indicating that they had undergone purifying selection during soybean genome expansion. Cis-acting element analysis revealed that GmKCS promoters contained multiple hormone- and stress-responsive elements, indicating that GmKCS gene expression levels may be regulated by various developmental and environmental stimuli. Expression profiles derived from RNA-seq data and qRT-PCR experiments indicated that GmKCSgenes were diversely expressed in different organs/tissues, and many GmKCS genes were found to be differentially expressed in the leaves under cold, heat, salt, and drought stresses, suggesting their critical role in soybean resistance to abiotic stress.
Conclusions: Thirty-one KCSgenes were identified and characterized in soybean, and their expression profiles under abiotic stress conditions suggested their potential roles in stress tolerance. These results providefundamental information about the soybean KCSgenes and will aid in their further functional elucidation and exploitation.
Trends in cancer-related suicide in the United States: a population-based cohort study spanning 40 years of data
Authors: Wang Jing , Liu Qiang , Qu Zheng , Dong Hao , Qi Yihang , Zhang Wenxiang , Wang Xiangyu , Fang Yi 
Published: October 2023

Abstract

There is a lack of large cohort studies examining trends in cancer-related suicide. This study addresses this gap by analyzing data from the Surveillance, Epidemiology, and End Results (SEER) database, encompassing a total of 4,870,410 patients diagnosed with cancer from 1975 to 2017. Age-adjusted suicide rates were examined using joinpoint regression to estimate the annual percent change (APC) and average annual percentage change (AAPC). In the past 40 years, studies have revealed a gradual increase in cancer-related suicide rates from 1975 to 1989, followed by a gradual decrease from 1989 to 2013, and a marked decrease from 2013 to 2017. These trends indicate the potential impact of advancements in psychosocial care for patients with cancer in contributing to the observed decrease in suicide rates.
Autonomous Swab Robot for Naso- and Oropharyngeal COVID-19 Screening
Authors: Haddadin Simon , Wilhelm Dirk , Wahrmann Daniel , Tenebruso Fabio , Sadeghian Hamid , Naceri Abdeldjallil , Haddadin Sami 
Published: October 2023

Abstract
The COVID-19 outbreak triggered a global health and economic crisis. With widespread cases and fatalities, testing is crucial to control viral spread. A recommended method, the combined naso-and oropharyngeal swab, poses risks and requires limited protective gear. In response to the COVID-19 pandemic, we developed and tested the first autonomous Swab Robot for Naso-and Oropharyngeal Coronavirus Screening (SR-NOCS). This groundbreaking device underwent two clinical studies—one conducted during the initial pandemic lockdown in Europe and the other after the pandemic had subsided early this year in a public place. In total, 52 patients suspected of COVID-19 infection were included in these clinical studies. The results showed a complete positive correlation between autonomous and manual sampling. The subject acceptance rate was very high; all test subjects stated they would repeat a test by SR-NOCS in the future. Based on these results, such systems could augment testing capabilities with the potential to conduct up to 300 tests per robot per day with the same precision in all the tests. Moreover, these tests can be conducted with minimum supervision and reduce infection risks, effectively protecting patients and healthcare workers and sparing personal protection equipment.
Frontiers and Hotspots Evolution between air pollution and Alzheimer’s: A Bibliometric Analysis From 2013 to 2023.
Authors: Hu Bingshuang , Tang Ju , Cheng BaoJing , Zhang LuShun 
Published: October 2023

Abstract
Background: In recent years, there is receiving incremental attention of researches on the air pollution. the studies associated to AD (Alzheimer’s disease) has scaled up progressively, yet the summarize of air pollution in AD are missing.
Objective: Finding research hotspots of air pollution in AD, grasping the direction of curative research, and promoting the development of research of air pollution in AD.
Material and Methods: According to specific key words, documents are combed in the core data set of Web of Science. CiteSpace, VOSviewer, Tableau are used to conduct statistical analysis on measurement indicators such as publishing countries, co-occurrence, subject matter area, co-authors and to visualize of a network of related content elements.
Results: It shows an upward trend in the field of air pollution in AD. Countries' cooperation is connected closely in air pollution and AD, and mainly interdisciplinary subjects involve environmental sciences, neurosciences, toxicology and public environmental occupational health. The research devotes discussion to the relationship between air pollution and AD. Keywordhotspots include Alzheimer' disease, particulate factor, ozone, inflammatory degeneration, and other research, and inseparably associates to new technologies. Overall, 249 reports on air pollution and AD from 2013 to 2023 were retrieved from Web of Science. 321 journals Published relevant literature, and literature has increased gradually since the past decade. US contains the most research records (130 publications and 4,230 citations).
Conclusion: The study revealed that the publications and citations related to air pollution and AD have grown over the last decade. The research and development of air pollution in AD advance quickly. However, there is not making an obvious breakthrough, and still need to establish more connections with multidisciplinary technology to explore cutting-edge hotspots
The value of dynamic FDG PET/CT in the differential diagnosis of lung cancer and predicting EGFR mutations
Authors: Wumener Xieraili , Zhang Yarong , Zang Zihan , Du Fen , Ye Xiaoxing , Zhang Maoqun , Liu Ming , Zhao Jiuhui , Sun Tao , Liang Ying 
Published: October 2023

Abstract

Introduction:
This study aims to evaluate the value of the quantitative metabolic parameters derived from dynamic 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT) in the differential diagnosis of lung cancer and predicting epidermal growth factor receptor (EGFR) mutation status.
Methods:
We included 147 patients with lung lesions who were enrolled to perform FDG PET/CT dynamic + static imaging with informed consent. Based on the results of puncture and postoperative pathology, the patients were divided into benign and malignant groups, adenocarcinoma (AC) and squamous carcinoma (SCC) groups and EGFR-positive (EGFR+) and EGFR-negative (EGFR-) groups. Quantitative parameters including K1, k2, k3, and Ki of each lesion were obtained by applying the irreversible two-tissue compartment modeling using in-house Matlab software. The standardized uptake values (SUV) analysis from conventional static data. Differences in each metabolic parameter among the groups were analyzed. Wilcoxon rank-sum test or Independent-samples T-test and receiver-operating characteristic (ROC) analyses were performed on each parameter to compare the diagnostic effects among the differentiated group. P<0.05 were considered statistically significant for all tests.
Results:
In the malignant group (N=124), the SUVmax, k2, k3, and Ki were higher than the benign group (N=23), and all have good performance in the differential diagnosis (P<0.05, respectively). In the AC group (N=88), the SUVmax, k3, and Ki were lower than in the SCC group, and the differences were statistically significant (P<0.05, respectively). For ROC analysis, when the Ki cut-off value of 0.0250 ml/g/min have better diagnostic specificity than SUVmax (0.999 vs 0.70). In AC group, 48 patients underwent EGFR testing. In the EGFR (+) group (N=31), the average Ki (0.0279±0.0153 ml/g/min) was lower than EGFR (-) group (N=17, 0.0405±0.0199 ml/g/min), and the differences were statistically significant (P<0.05). However, the SUVmax, and k3 did not show such a difference between EGFR (+) and EGFR (-) groups (P＞0.05, respectively). For ROC analysis, the Ki had a cut-off value of 0.0350 ml/g/min for predicting EGFR status, a sensitivity of 0.710, a specificity of 0.588, and an AUC of 0.674 [0.523-0.802].
Conclusion:
When the cut-off value of Ki was 0.0250 ml/g/min, there was a more specificity than SUVmax for the differential diagnosis of lung cancer, although both methods were specific. The Ki has a good diagnostic value in the prediction of the EGFR status. For patients for whom EGFR testing is not available, dynamic imaging may become an important non-invasive screening tool.
Effect of oral anti-coagulant on 12-month overall mortality rate in admitted elderly patient with newly diagnosed atrial fibrillation and atrial flutter
Authors: Wattanawongwon Narongchai , Winijkul Arjbordin 
Published: October 2023

Abstract
Background
Atrial fibrillation increases risk of ischemic stroke which leading to disability and mortality. However, benefit of early initiation of treatment for stroke prevention in elderly with newly diagnosed AF during hospitalization for non-cardiac reasons is questionable.
Methods
We performed a retrospective cohort study in hospitalized patients from Siriraj hospital between 2003 to 2019. Participants with aged more than 75-year-old and newly diagnosed AF were included. Primary outcome was an overall mortality. Secondary outcomes were in-hospital mortality, non-fatal stroke, and bleeding event.
Results
A total of 216 participants: 24 in the oral anticoagulant (OAC) group and 192 in the non-OAC group. Most oral anti-coagulant use was warfarin (91.7%). The mean age was 81.9 years in the OAC group and 82.9 in the non-OAC group. The mean CHA2DS2VASc score was 4.5 in the OAC group and 4.2 in the non-OAC group. The mean HAS-BLED score was 3.0 both groups. During index admission, there were 1 death in the OAC group and 83 deaths in the non-OAC group. Over the course of 1-year follow-up, there were 6 deaths in the OAC group and 107 in the non-OAC group. The HR was 0.33 (95% confident interval [CI], 0.15-0.75; p-value = 0.08). Non-CV death were 96.4% of all deaths. After an exclusion of in-hospital mortality, there were 5 deaths (21.7%) in the OAC group and 24 deaths (22%) in the non-OAC group. The hazard ratio was 0.93 (95% CI, 0.36-2.42; p-value = 0.879). There were 4 non-fatal strokes in the non-OAC group but none in the OAC group. There were 3 bleeding events in the OAC group and 4 bleeding events in the non-OAC group. The hazard ratio was 6.11 (95% CI, 1.37-27.32; p-value = 0.018).
Conclusions
Non-CV death was the major cause of death during the hospitalization. Benefit of initiating OAC in patients with newly diagnosed AF during hospitalization may be limited by patients’ active conditions. However, stroke prevention after hospitalization should be considered.
Vitamin D is involved in the effects of the intestinal flora and its related metabolite TMAO on perirenal fat and kidneys in mice with DKD
Authors: Yang Mengxue , Zheng Xiaodi , Huang Yuhong , Jin Lulu , Zhang Xuemeng , Zhang Rui , Wu Yueyue , Yan Cuili , Gao Yuan , Zeng Miao , Li Fei , Zhou Xue , Zhang Neng , Liu Jun , Zha Bingbing 
Published: October 2023

Abstract

Vitamin D directly exerts a protective effect on the kidneys of individuals with diabetic kidney disease (DKD) in our previous study. However, whether it has an effect on perirenal adipose tissue (PRAT) or the intestinal flora and its metabolites (trimethylamine N-oxide, TMAO) is unclear. We found that 1,25-(OH)2D3 could improve the dysbiosis of the intestinal flora of mice with DKD, increase the abundance of beneficial bacteria such as lactic acid bacteria, decrease the abundance of harmful bacteria such as Escherichia, reduce the pathological changes in kidney histopathology, reduce fat infiltration, and downregulate the mRNA expression of TLR4 and NF-κB in kidney tissue. We also found that the serum TMAO concentration in mice with DKD was significantly higher than that of the control group, and serum TMAO content was significantly positively correlated with urine ACR. In addition, vitamin D stimulated the expression of the surface markers PGC1α, UCP-1 and VDR in the PRAT in mice with DKD, and TMAO downregulated the expression of PRAT and renal VDR. The above results show that the renal protective effect of 1,25-(OH)2D3 on mice with DKD may also be related to the improvement of the intestinal mucosal barrier, composition of the intestinal flora and its metabolites, inhibition of the TLR4/NF-κB inflammatory pathway and reduction in PRAT metabolite effects on the kidney. This study provides a theoretical basis for the use of hypoglycemic drugs combined with vitamin D therapy to improve diabetic nephropathy.
Taihangia rupestris: First Genome Survey and Microsatellite Motif Identification
Authors: Zhou Baoying , Chen Hongzhi , Meng Li , Song Linlin 
Published: October 2023

Abstract

Taihangia rupestris(T. rupestris) is a perennial herb on the China species red list that grows on the cliffs of Taihang Mountain. However, there has been limited research on the genome of T. rupestris, severely restricting further research. Here, a first genome survey of T. rupestris was conducted. The genome size and characteristics of T. rupestris were estimated using Illumina HiSeq X Ten and K-mer analysis, respectively. Additionally, simple sequence repeat predictions were obtained tested. The genome size of T. rupestris was estimated to be 976.97 Mb, with a heterozygosity rate of 0.726% and sequence repetition rate of 56.93%. The clean reads were assembled into 100,973 contigs, with the max length of 26,073 bp and an N50 value of 2,607 bp. Based on the T. rupestris genome data, 805,600 simple sequence repeat markers were identified and 72,769 pairs of primers were designed. In the present study, 100 primers were tested and 82 resulted in successful amplicon generation. In total, 15 primer pairs amplifying good polymorphisms effectively distinguished different T. rupestris populations. In general, the T. rupestris genome was difficult to assemble owing to micro-heterozygosity and high repetition levels. These analyses lay a foundation for the subsequent whole-genome sequencing of T. rupestris.
User-engagement in digital health applications: a scoping review
Authors: AKTAS Melek , CAMBON Linda , AROMATARIO Olivier 
Published: October 2023

Abstract

Background Participation has moved from political protest to active engagement in a number of areas health. Patient engagement has transformed healthcare, and mHealth has put mobile technology at the service of health promotion. Research links user engagement to effective interventions. This review aims to understand the attributes, methods and barriers to this user engagement in mHealth. Methods This scoping review used a systematic approach to map the evidence on mHealth interventions for health promotion and prevention in accordance with the PRISMA-ScR guidelines. Scopus, Web of Science and PubMed databases were searched using keywords appropriate to each database. A two-stage selection process was used and the analysis focused on attributes of participation, methods of engagement and barriers/facilitators. Results The study analysed mHealth interventions for health promotion and prevention. From 1,533 articles, 782 were obtained and 41 were selected for analysis on the basis of pre-defined inclusion and exclusion criteria. There are different definitions and attributes of engagement, depending on the discipline and the author. There are also scales and gradations of engagement that qualify engagement according to its intensity or within the mHealth tool. User engagement methods included theory-based interventions, behaviour change techniques, user-centred design, personalisation, autonomy, peer support, motivation and gamification. Challenges included barriers to technology adoption, lack of theory-based interventions, personalisation, autonomy, peer support, motivation and gamification. Conclusion The current understanding of user participation in digital interventions reveals complexity and diversity, lacking consensus. Definitions vary among intervention providers, reflecting distinct objectives and methodologies. The absence of clear concepts and attributes emphasizes the need to refine definitions in digital health, guiding intervention evaluation and development methodologies.
Microplastic accumulation in sewer sediments and its potential entering the environment via combined sewer overflows: a study case in Paris
Authors: NGUYEN Minh Trang , PHUONG Ngoc Nam , SAAD Mohamed , TASSIN Bruno , GILLET Thomas , GUÉRIN-RECHDAOUI Sabrina , AZIMI Sam , ROCHER Vincent , GASPERI Johnny , DRIS Rachid 
Published: October 2023

Abstract
During wet weather events, combined sewer overflows (CSOs) transfer large amount of particulate matter and associated pollutants into surrounding water bodies, thereby deteriorating the recipients’ ecological health. Resuspension of sewer sediments during these events contribute significantly to pollution level of these discharges. However, how much this in-sewer process contributes to CSOs’ quality regarding microplastic (MP) pollution is little known. Therefore, an investigation on sewer deposits inside the Parisian combined sewer network was carried out. The study found high MP concentrations stored in this matrix, ranging from 5×103 to 178×103 particle/kg dry weight. Polymer composition is similar to what found in raw wastewater, containing a high proportion of polyethylene and polypropylene. Thus, the results indicated the retainment of MPs in sewer network during transport during dry weather periods to treatment facilities. Once resuspension of sewer deposits happens, MPs can be released into water flow and get discharged along with CSOs. This highlights another potential pathway of MPs into freshwater environment.
Community Animal Health Workers (CAHWs) contribution in detection and response to priority transboundary animal diseases and zoonoses in Guinea, Liberia and Sierra Leone
Authors: Sow Adama , Kane Yaghouba , Boka Marcel , Kohagne Kohagné-Tongué Lisette , Bitek Austine , Nantima Noelina , Ouagal Mahamat , Ndiaye Racine , Ahmed Ibrahim , Bobo Germain , Seck Ismaila , Wolde Abebe , Soumare Baba 
Published: October 2023

Abstract

Veterinary services, including disease surveillance, animal healthcare delivery, were poorly structured in the Mano River countries (Guinea, Liberia and Sierra Leone) due to insufficient and inadequate qualified human resources, infrastructures, and motivation. To support the national veterinary services in their endeavors, FAO ECTAD, through the Global Health Security Agenda funded by the United States Agency for International Development, supported the training of Community Animal Health Workers (CAHWs) and their involvement in the animal diseases surveillance system and response in these countries. A total of 8,417 CAHWs (8 000 in Guinea, 228 in Liberia and 189 in Sierra Leone) were trained. The contents of the training in Liberia and Sierra Leone included veterinary health care delivery, while in Guinea the themes were focused on disease recognition and reporting. As results, CAHWs were able to report outbreaks of priority animal diseases including zoonoses in Liberia (n = 120) and Sierra Leone (n = 600). CAHWs also contributed to the vaccination campaign against Peste des Petits Ruminants, Newcastle Disease, and rabies in Sierra Leone. In Guinea, 1134 animal health events were notified with the collaboration of CAHWs from 2018 to 2020. Thus, CAHWs are contributing to improved surveillance in all the three countries. Governments and private sector should engage incentive conditions to sustain CAHWs work within the animal health system in the context of one health approach. Sustaining the important role of CAHWs to the animal health services requires the creation of a viable incentive mechanism supported by the Government and the private sector.