bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studi Meta-Analisis : Effektivitas Penggunaan Media Pembelajaran dalam Meningkatkan Hasil Belajar Siswa pada Mata Pelajaran IPA
Authors: Nengsih Cindy Oktafina , Arsih Fitri , Zulyusri Zulyusri , Lufri Lufri 
Published: November 2023

Mata pelajaran IPA ialah mata pelajaran yang membutuhkan banyak media pembelajaran sebagai penunjang materi ajar bahkan pada umumnya dapat dikatakan bahwa materi IPA tidak dapat dipahami dengan baik apabila tanpa bantuan media pembelajaran. Media pembelajaran yang digunakan meliputi, media pembelajaran di dalam kelas seperti LCD komputer untuk menayangkan contoh visualisasi dari proses pembelajaran, dan penggunaan media lainnya. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan media pembelajaran dalam meningkatkan hasil belajar siswa pada mata pelajaran IPA tingkat SD, SMP, maupun SMA. Metode yang digunakan dalam penelitian ini adalah meta-analisis dengan melakukan telaah terhadap 20 artikel yang terbit di jurnal nasional yang berkaitan dengan penelitian ini. Analisis data yang digunakan adalah analisis data kuantitatif dimana penelitian ini memadukan hasil penelitian untuk mengetahui efektivitas penggunaan media pembelajaran terhadap hasil belajar siswa. Berdasarkan hasil analisis, penggunaan berbagai media pembelajaran IPA menggunakan nilai pretest dan posttest siswa. Hasil effect size menunjukkan nilai rata-rata 1.1 dengan kategori efek sangat besar. Hal ini menunjukkan bahwa dengan menggunakan media pembelajaran lebih efektif dalam meningkatkan hasil belajar siswa pada mata pelajaran IPA.
Development of a machine learning-based model for predicting risk of early postoperative recurrence of hepatocellular carcinoma
Authors: Zhang Yu-Bo , Yang Gang , Bu Yang , Lei Peng , Zhang Wei , Zhang Dan-Yang 
Published: November 2023

BACKGROUND
Surgical resection is the primary treatment for hepatocellular carcinoma (HCC). However, studies indicate that nearly 70% of patients experience HCC recurrence within five years following hepatectomy. The earlier the recurrence, the worse the prognosis. Current studies on postoperative recurrence primarily rely on postoperative pathology and patient clinical data, which are lagging. Hence, developing a new pre-operative prediction model for postoperative recurrence is crucial for guiding individualized treatment of HCC patients and enhancing their prognosis.
AIM
To identify key variables in pre-operative clinical and imaging data using machine learning algorithms to construct multiple risk prediction models for early postoperative recurrence of HCC.
METHODS
The demographic and clinical data of 371 HCC patients were collected for this retrospective study. These data were randomly divided into training and test sets at a ratio of 8:2. The training set was analyzed, and key feature variables with predictive value for early HCC recurrence were selected to construct six different machine learning prediction models. Each model was evaluated, and the best-performing model was selected for interpreting the importance of each variable. Finally, an online calculator based on the model was generated for daily clinical practice.
RESULTS
Following machine learning analysis, eight key feature variables (age, intratumoral arteries, alpha-fetoprotein, pre-operative blood glucose, number of tumors, glucose-to-lymphocyte ratio, liver cirrhosis, and pre-operative platelets) were selected to construct six different prediction models. The XGBoost model outperformed other models, with the area under the receiver operating characteristic curve in the training, validation, and test datasets being 0.993 (95% confidence interval: 0.982-1.000), 0.734 (0.601-0.867), and 0.706 (0.585-0.827), respectively. Calibration curve and decision curve analysis indicated that the XGBoost model also had good predictive performance and clinical application value.
CONCLUSION
The XGBoost model exhibits superior performance and is a reliable tool for predicting early postoperative HCC recurrence. This model may guide surgical strategies and postoperative individualized medicine.
Temporal speed prevails on interval duration in the SNARC-like effect for tempo
Authors: Mariconda Alberto , Murgia Mauro , De Tommaso Matteo , Mingolo Serena , Agostini Tiziano , Prpic Valter 
Published: November 2023

AbstractThe Spatial-Numerical Association of Response Codes (SNARC) effect is evidence of an association between number magnitude and response position, with faster left-key responses to small numbers and faster right-key responses to large numbers. Similarly, recent studies revealed a SNARC-like effect for tempo, defined as the speed of an auditory sequence, with faster left-key responses to slow tempo and faster right-key responses to fast tempo. In order to address some methodological issues of previous studies, in the present study we designed an experiment to investigate the occurrence of a SNARC-like effect for tempo, employing a novel procedure in which only two auditory beats in sequence with a very short interstimulus interval were used. In the “temporal speed” condition, participants were required to judge the temporal speed (slow or fast) of the sequence. In the “interval duration” condition, participants were required to judge the duration of the interval between the two beats (short or long). The results revealed a consistent SNARC-like effect in both conditions, with faster left-hand responses to slow tempo and faster right-hand responses to fast tempo. Interestingly, the consistency of the results across the two conditions indicates that the direction of the SNARC-like effect was influenced by temporal speed even when participants were explicitly required to focus on interval duration. Overall, the current study extends previous findings by employing a new paradigm that addresses potential confounding factors and strengthens evidence for the SNARC-like effect for tempo.
Candidiasis Vulvovaginal y Susceptibilidad Antifúngica en Gestantes de la Sierra Andina – Huancavelica
Authors: Dueñas paitan Denis Rocio , Muñoz de la Torre Rossibel Juana 
Published: November 2023

Objetivo: Determinar la frecuencia de infección por candidiasis vulvovaginal y susceptibilidad antifúngica en gestantes de la Sierra andina – Huancavelica..Materiales y metodos:Estudio retrospectivo, observacional, descriptivo y de gestantes con candidiasis vulvovaginal y susceptibilidad antifúngica atendidas en el hospital departamental de Huancavelica y el centro de salud de ascensión e el año 2022 ,se aplicó la técnica de análisis documentario y el instrumento la cual fue una ficha de recolección de datos .Resultados: Se analizaron 160 gestantes donde las características sociodemográficas de mayor frecuencia fueron añosa en un 49,4% (79); estado civil soltera el 33.1% (53), con grado de instrucción secundaria 54.4 % (87). Entre las características obstétricas se halló diagnósticos en el III Trimestre 54% (87) y gran multípara en un 28.8% (46). El Agente etiológico de mayor frecuencia fue la cándida albicans 86.9% (139), el servicio donde se hizo el diagnóstico fue en el consultorio de ginecoobstetricia 88,1% (141),la susceptibilidad antifúngica resultó sensible a los triazoles (fluconazol) el 75.6% y a los Imidazoles (clotrimazol) solo el 12.8%.Conclusiones: La candidiasis vulvovaginal en las gestantes se presentó con mayor frecuencia en añosas, convivientes, con secundaria; el agente etiológico fue la candidiasis albicans y es sensible al fluconazol .
Sistemas Hidropónicos Sustentables Basados en el Reciclaje de Botellas de PET e Impresión 3D
Authors: Vichique Alegría Manuel , Hernández Bernabé Jose Luis , Castillo Guevara Abimael 
Published: November 2023

Se comparte con el lector el avance obtenido de la experimentación en el desarrollo de una nueva propuesta de hidroponia tipo NFT basada en integrar el reciclaje de botellas de PET y diseños en impresión 3d. Esto con la finalidad de proponer un nuevo método de cultivo de hortalizas el cual ahorre aún mas agua que los sistemas conocidos e igualmente pueda repercutir positivamente en el medio ambiente. Es importante aclarar que la técnica de película de nutrientes (nft) es un sistema hidropónico en el que las plantas se cultivan en canales poco profundos con una película de solución nutritiva que fluye continuamente sobre las raíces de las plantas. (Hernández, 2005) Se propone el uso de la metodología de experimentación pura para establecer una relación causal entre la confiabilidad del sistema hidropónico y los resultados en las hortalizas cosechadas, medidos en términos de peso, tamaño y calidad. Finalmente se abordarán temas técnicos tales como construcción del sistema, formulas nutrimentales para las hortalizas y evidencias que respalden gráficamente el desarrollo de este sistema.
CLASH-VLT: The Inner Slope of the MACS J1206.2-0847 Dark Matter Density Profile
Authors: Biviano Andrea , Pizzuti Lorenzo , Mercurio Amata , Sartoris Barbara , Rosati Piero , Ettori Stefano , Girardi Marisa , Grillo Claudio , Caminha Gabriel B. , Nonino Mario 
Published: November 2023

Abstract
The inner slope (γ
DM) of the dark matter (DM) density profile of cosmological halos carries information about the properties of DM and/or baryonic processes affecting the halo gravitational potential. Cold DM cosmological simulations predict steep inner slopes, γ
DM ≃ 1. We test this prediction on the MACS J1206.2-0847 cluster at redshift z = 0.44, whose DM density profile has been claimed to be cored at the center. We determine the cluster DM density profile from 2 kpc from the cluster center to the virial radius (∼2 Mpc), using the velocity distribution of ≃500 cluster galaxies and the internal velocity dispersion profile of the Brightest Cluster Galaxy (BCG), obtained from VIMOS@VLT and MUSE@VLT data. We solve the Jeans equation of dynamical equilibrium using an upgraded version of the MAMPOSSt method. The total mass profile is modeled as a sum of a generalized Navarro–Frenk–White profile that describes the DM component, allowing for a free inner slope of the density profile, a Jaffe profile that describes the BCG stellar mass component, and a nonparametric baryonic profile that describes the sum of the remaining galaxy stellar mass and of the hot intra-cluster gas mass. Our total mass profile is in remarkable agreement with independent determinations based on X-ray observations and strong lensing. We find

γ

DM

=

0.7

−
0.1

+
0.2

(68% confidence levels), consistent with predictions from recent Lambda cold dark matter cosmological numerical simulations.
Gas-phase Metallicity of Local Active Galactic Nuclei in the GASP and MaNGA Surveys: The Role of Ram Pressure Stripping
Authors: Peluso Giorgia , Radovich Mario , Moretti Alessia , Mingozzi Matilde , Vulcani Benedetta , Poggianti Bianca M. , Marasco Antonino , Gullieuszik Marco 
Published: November 2023

Abstract
Growing evidence in support of a connection between active galactic nuclei (AGN) activity and the ram pressure stripping (RPS) phenomenon has been found both observationally and theoretically in the past decades. In this work, we further explore the impact of RPS on the AGN activity by estimating the gas-phase metallicity of nuclear regions and the mass–metallicity relation of galaxies at z ≤ 0.07 and with stellar masses

log

M

*

/

M

⊙

≥
9.0

, either experiencing RPS or not. To measure oxygen abundances, we exploit Integral Field Spectroscopy data from the GASP and MaNGA surveys, photoionization models generated with the code Cloudy and the code Nebulabayes to compare models and observations. In particular, we build Cloudy models to reproduce line ratios induced by photoionization from stars, AGN, or a contribution of both. We find that the distributions of metallicity and [O iii] λ5007 luminosity of galaxies undergoing RPS are similar to the ones of undisturbed galaxies. Independently of the RPS, we do not find a correlation between stellar mass and AGN metallicity in the mass range

log

M

*

/

M

⊙

≥
10.4

, while for the star-forming galaxies we observe the well-known mass–metallicity relation between

9.0
≤
log

M

*

/

M

⊙

≤
10.8

with a scatter mainly driven by the star formation rate and a plateau around

log

M

*

/

M

⊙

∼
10.5

. The gas-phase metallicity in the nuclei of AGN hosts is enhanced with respect to those of star-forming galaxies by a factor of ∼ 0.05 dex regardless of the RPS.
Unraveling the Complex Structure of AGN-driven Outflows. VI. Strong Ionized Outflows in Type 1 AGNs and the Outflow Size–Luminosity Relation
Authors: Kim Changseok , Woo Jong-Hak , Luo Rongxin , Chung Aeree , Baek Junhyun , N. Le Huynh Anh , Son Donghoon 
Published: November 2023

Abstract
We present spatially resolved gas kinematics, ionization, and energetics of 11 type 1 and 5 type 2 active galactic nuclei (AGNs) with strong ionized gas outflows at z <0.3 using Gemini Multi-Object Spectrograph Integral Field Unit data. We find a strongly blueshifted region in [O iii] velocity maps, representing an approaching cone in biconical outflows, and blueshifted and redshifted regions in Hα velocity maps, which show gravitationally rotating kinematics. AGN photoionization is dominant in the central region of most targets, and some of them also show ring-like structures of LINER or composite that surround the AGN-dominated center. Following our previous studies, we kinematically determine outflow sizes by the ratio between [O iii] and stellar velocity dispersion. Outflow sizes of type 1 AGNs follow the same kinematic outflow size–[O iii] luminosity relation obtained from the type 2 Integral Field Unit sample in Kang & Woo and Luo (updated slope 0.29 ± 0.04), while they are limited to the central kiloparsec scales, indicating the lack of global impact of outflows on the interstellar medium. Small mass outflow rates and large star formation rates of the combined sample support that there is no evidence of rapid star formation quenching by outflows, which is consistent with the delayed AGN feedback.
Screening Earth Analog Exoplanets on the Basis of a Predicted Nitrogen over Phosphorus Ratio
Authors: Toulhoat Hervé 
Published: November 2023

Abstract
Since the first discovery in 1995, data for over 5300 exoplanets have been documented in the NASA archive, revealing a vast diversity. Identifying life-enabling analogs of the Earth among this rapidly expanding catalog is of major interest. The stability of liquid water at the planetary surface defining the concept of the habitable zone (HZ) around the host star, may be necessary for the emergence of life as we know it but not sufficient. The practically constant atomic ratio nitrogen:phosphorous = 16:1 in oceanic surface layers of our planet Earth was discovered by Redfield in 1934. It corresponds to phytoplanktonic biomass in suspension and appears optimal to fertilize phytoplankton development and therefore the food pyramid of marine life. Loladze and Elser have shown that it corresponds to a homeostatic protein:RNA ratio and is therefore “rooted in the stoichiometry of the foundational structures of life.” I show that according to the recent theory of the chemical differentiation of planets, this optimal ratio is also an intrinsic chemical property of our planet Earth uniquely determined in the solar system by its average orbital radius. On that basis, I propose a criterion of fertility within the HZ of a stellar system, which when applied to screen the public database allows us to sort out an extended list of up to 74 Earth analogs. The latter and its future extensions could provide priority targets for focused detection techniques.
Disk Cooling and Wind Lines as Seen in the Spectral Line Evolution of V960 Mon
Authors: Carvalho Adolfo , Hillenbrand Lynne , Seebeck Jerome 
Published: November 2023

Abstract
We follow up our photometric study of the postoutburst evolution of the FU Ori object V960 Mon with a complementary spectroscopic study at high dispersion that uses time series spectra from the Keck/HIgh Resolution Echelle Spectrograph. Consistent with the photometric results reported in Carvalho et al., we find that the spectral evolution of V960 Mon corresponds to a decrease in the temperature of the inner disk, driven by a combination of a decreasing accretion rate and an increasing inner disk radius. We also find that although the majority of the absorption lines are well matched by our accretion disk model spectrum, there are several strong absorption line families and a few emission lines that are not captured by the model. By subtracting the accretion disk model from the data at each epoch, we isolate the wind and outflow components of the system. The residuals show both broad and highly blueshifted profiles, as well as narrow and only slightly blueshifted profiles, with some lines displaying both types of features.
ALMA 400 pc Imaging of a z = 6.5 Massive Warped Disk Galaxy
Authors: Neeleman Marcel , Walter Fabian , Decarli Roberto , Drake Alyssa B. , Eilers Anna-Christina , Meyer Romain A. , Venemans Bram P. 
Published: November 2023

Abstract
We present 0.″075 (≈400 pc) resolution Atacama Large Millimeter/submillimeter Array (ALMA) observations of the [C ii] and dust continuum emission from the host galaxy of the z = 6.5406 quasar, P036+03. We find that the emission arises from a thin, rotating disk with an effective radius of 0.″21 (1.1 kpc). The velocity dispersion of the disk is consistent with a constant value of 66.4 ± 1.0 km s−1, yielding a scale height of 80 ± 30 pc. The [C ii] velocity field reveals a distortion that we attribute to a warp in the disk. Modeling this warped disk yields an inclination estimate of 40.°4 ± 1.°3 and a rotational velocity of 116 ± 3 km s−1. The resulting dynamical mass estimate of (1.96 ± 0.10) × 1010
M
⊙ is lower than previous estimates, which strengthens the conclusion that the host galaxy is less massive than expected based on local scaling relations between the black hole mass and the host galaxy mass. Using archival MUSE Lyα observations, we argue that counterrotating halo gas could provide the torque needed to warp the disk. We further detect a region with excess (15σ) dust continuum emission, which is located 1.3 kpc northwest of the galaxy’s center and is gravitationally unstable (Toomre Q < 0.04). We posit this is a star-forming region whose formation was triggered by the warp because the region is located within a part of the warped disk where gas can efficiently lose angular momentum. The combined ALMA and MUSE imaging provides a unique view of how gas interactions within the disk–halo interface can influence the growth of massive galaxies within the first billion years of the Universe.
Un enjeu de recherche fondamentale et clinique
Authors: Lethimonnier Franck , Samuel Didier 
Published: November 2023

La recherche en biothérapies et en bioproduction est au cœur de l’innovation médicale. Le transfert de ces découvertes vers la clinique et l’industrie est crucial. Depuis 2005, l’Inserm et les CHU ont créé des CIC dédiés, propulsant la France vers des avancées pionnières. En France, environ 100 équipes de recherche travaillent sur des biothérapies innovantes, et 50 autres se concentrent sur la bioproduction. Les avancées en édition génique et en biologie synthétique élargissent les possibilités. Les avancées en ARNm montrent également leur potentiel thérapeutique. La recherche est structurée avec des centres cliniques, des infrastructures de recherche et des accélérateurs de recherche technologiques. Pour encourager le transfert industriel, des « Intégrateurs Biothérapies – Bioproduction » ont été labellisés. La recherche française a progressé dans les biothérapies, avec des succès et des start-up innovantes. La prise de conscience récente de l’importance du domaine renforce cette dynamique.
Multifocal Polypseudophakia With Rayner Sulcoflex Trifocal and In-the-Bag Alcon PanOptix Diffractive Trifocal Intraocular Lenses: A Case Report
Authors: Mallick Pauline , Rossiter-Thornton Michael , Azar Domit 
Published: November 2023

Purpose:
To describe the use of a sulcus diffractive multifocal intraocular lens (IOL) used in series with an intracapsular diffractive multifocal IOL to improve uncorrected near visual acuity (UNVA).

Methods:
A 66-year-old pseudophakic woman with bilateral multifocal IOLs presented with symptoms of negative dysphotopsia and poor reading vision in the right eye. A diffractive multifocal sulcus IOL was inserted in the right eye.

Results:
After 1 month, the patient's right UNVA had improved from N10 to N6. Subjectively there was a 50% improvement in negative dysphotopsia and no increase in photic phenomena.

Conclusions:
A diffractive trifocal secondary sulcus IOL can be used in series with an intracapsular diffractive trifocal lens. The success of this approach suggests that it may be used to both improve negative dysphotopsia and address postoperative refractive error.

[
Journal of Refractive Surgery Case Reports.
2023;3(4):e53–e55.]
Both Humoral and Cellular Immunity Limit the Ability of Live Attenuated Influenza Vaccines to Promote T Cell Responses
Authors: Lobby Jenna L , Danzy Shamika , Holmes Katie E , Lowen Anice C , Kohlmeier Jacob E 
Published: November 2023

Abstract
One potential advantage of live attenuated influenza vaccines (LAIVs) is their ability to establish both virus-specific Ab and tissue-resident memory T cells (TRM) in the respiratory mucosa. However, it is hypothesized that pre-existing immunity from past infections and/or immunizations prevents LAIV from boosting or generating de novo CD8+ T cell responses. To determine whether we can overcome this limitation, we generated a series of drifted influenza A/PR8 LAIVs with successive mutations in the hemagglutinin protein, allowing for increasing levels of escape from pre-existing Ab. We also inserted a CD8+ T cell epitope from the Sendai virus nucleoprotein (NP) to assess both generation of a de novo T cell response and boosting of pre-existing influenza-specific CD8+ T cells following LAIV immunization. Increasing the level of escape from Ab enabled boosting of pre-existing TRM, but we were unable to generate de novo Sendai virus NP+ CD8+ TRM following LAIV immunization in PR8 influenza-immune mice, even with LAIV strains that can fully escape pre-existing Ab. As these data suggested a role for cell-mediated immunity in limiting LAIV efficacy, we investigated several scenarios to assess the impact of pre-existing LAIV-specific TRM in the upper and lower respiratory tract. Ultimately, we found that deletion of the immunodominant influenza NP366–374 epitope allowed for sufficient escape from cellular immunity to establish de novo CD8+ TRM. When combined, these studies demonstrate that both pre-existing humoral and cellular immunity can limit the effectiveness of LAIV, which is an important consideration for future design of vaccine vectors against respiratory pathogens.
Nuevas regulaciones, mismos problemas: el consentimiento informado de niños, niñas y adolescentes en Chile tras la reforma a la Ley Nº 20.584
Authors: Marshall Pablo , Iuspa Carla , Godoy Loreto 
Published: November 2023

El presente trabajo expone las innovaciones legislativas que la Ley 21.331, de Salud Mental, incorpora en la legislación sanitaria en lo que respecta a los niños, niñas y adolescentes, situándolas en relación con el contexto más amplio de los estándares internacionales de derechos humanos. Luego se concentra en mostrar cómo los problemas de interpretación existentes en el texto original de la Ley 20.584 respecto del consentimiento informado para procedimientos y tratamientos de salud en este grupo de personas no son solucionados (o al menos no del todo) por la reforma. Por el contrario, la nueva regulación introduce nuevos problemas de interpretación que hacen permanecer al consentimiento informado de niños, niñas y adolescentes en un terreno legalmente incierto.