bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multistage stochastic programming approach for short-term scheduling of batch processes under type II endogenous uncertainty
Authors: Menon Kavitha , Fukasawa Ricardo , Ricardez-Sandoval Luis 
Published: December 2023

Abstract
In this study, we present a novel multistage stochastic programming approach for scheduling of batch operations under type II endogenous uncertainty (where time of uncertainty realization is model dependent). The proposed multistage framework follows a node-based formulation and enforces non-anticipativity implicitly. The key novelty of this approach is that it does not require any auxiliary binary variables or explicit non-anticipativity constraints (NACs). The proposed framework is validated using three different case studies: two case studies adapted from the literature and an actual large-scale industrial case study. Computational studies were conducted and VSS (value of stochastic solution) was estimated for all case studies. It was observed that with an increase in number of stages, the VSS also increases ranging from 4.4% to 11% for the industrial case study. We conducted a comparison study of the proposed approach with an approach involving binary variables to define NACs as most studies available in the literature use auxiliary binary variables to define NACs when type II uncertainties are involved. The results shows up to 85% reduction in the computational time while using the proposed node-based approach in comparison to using an approach that requires binary variables to define the NACs.
Trends in nutritional status and factors affecting prognostic nutritional index in ovarian cancer patients during chemotherapy: A prospective longitudinal study based on generalized estimating equations
Authors: Zhang Mengqin , He Yalin , Liu Xing , Liu Ya , Tian Yalin , Dan Xin , Ren Jianhua 
Published: December 2023

Abstract
Purpose
Numerous studies have investigated the relationships between nutritional status and the prognosis of ovarian cancer (OC). However, the majority of these studies have focused on pre-chemotherapy malnutrition, with limited attention given to dynamic changes in nutritional status during chemotherapy and the associated risk factors affecting the prognostic nutritional index (PNI) in OC women. This study aims to explore the variation trend in the nutritional status of OC women over time during chemotherapy and assess its predictive factors.
Methods
A prospective longitudinal study was conducted from January 2021 to August 2023. Body Mass Index (BMI), PNI, Nutritional Risk Screening (NRS) 2002, serum albumin, and prealbumin measurements were utilized to assess the nutritional status of OC women. Data were collected through face-to-face interviews before initial chemotherapy (T0) and during the first (T1), third (T2), and fifth (T3) cycles of chemotherapy. Generalized Estimating Equations (GEE) were employed for the analysis of potential predictive factors.
Results
A total of 525 OC women undergoing chemotherapy completed the study. Significantly varied levels of BMI, PNI, and serum concentrations of hemoglobin, albumin, prealbumin, potassium, sodium, magnesium, and calcium were observed in these patients (P༜0.05). The prevalence of nutritional risk decreased over time during chemotherapy (P༜0.05). Nutritional parameters, including BMI, PNI, and the serum concentrations of albumin and prealbumin, exhibited an upward trend in nutritional status throughout the chemotherapy cycles (P༜0.05). Multivariate analysis indicated that higher levels of BMI, serum albumin, prealbumin, absolute lymphocyte count, and hemoglobin ≥ 110g/L at admission were associated with elevated PNI after chemotherapy (β = 0.092, p = 0.011; β = 0.318, p < 0.001; β = 0.008, p = 0.002; β = 1.278, p < 0.001; β = 0.617, p = 0.009).
Conclusion
Patients consistently demonstrated improvements in nutritional risk and status from the initiation to the completion of chemotherapy cycles. Nutritional monitoring of OC women, particularly those exhibiting abnormalities at the commencement of chemotherapy, is crucial. Targeted nutritional support programs should be developed to enhance the prognosis of OC women.
An Improved Cigarette Defect Detection Algorithm Based on YOLOX
Authors: Weiya Shi , Shiqiang Zhang , Shaowen Zhang 
Published: December 2023

Abstract
Surface defect detection has always been a difficult challenge. Aiming at the detection of surface defects in cigarettes, an improved YOLOX-S model is proposed. Firstly, an improved attention mechanism named MS-GCT (Multi-Spectral Gaussian Context Transformer) is introduced in the backbone network to enhance the model’s ability to capture the global context information in the image and improve its understanding of semantic feature information; secondly, a DMG (Dynamic convolution and MS-GCT) module is proposed and combined with the C2f (CSPLayer with 2 convolutions) module to construct the C2f-DMG module,which is introduced into the model to enhance feature interaction, improve specific feature extraction ability, and strengthen long-distance dependency ability of global features; finally, the loss function is replaced with SIoU to improve model performance and accelerate model convergence. The effectiveness of the model is verified on both the self-made cigarette dataset and the public dataset. The experimental results show that the improved model not only ensures the lightweight of the model, but also improves the model mAP by 2.02, while achieving a detection speed of 73.17 frames− 1. The proposed algorithm also meets the real-time detection requirements for cigarette appearance defects.
Effects of Horticultural Therapy Combined with Intradermal Needle Therapy on Generalised Anxiety, Cortical Excitability and HPA-related Hormones in an Isolated Population during the COVID-19 Pandemic: Protocol for a Randomised Controlled Clinical Trial
Authors: Zhu Jiaxin , Cai Dongmei , Yan Jiayi , Chen Jiamin , Yan Luda , Li Jingjing , Mei Pengyu , Su Guang 
Published: December 2023

Abstract
Introduction:
Coronavirus disease 2019 (COVID-19) is a novel, highly infectious disease that is a severe danger to human life and has spawned a worldwide public health emergency. Most countries have implemented measures of isolation to prevent the spread of COVID-19, but related studies have shown that isolation increases the risk of anxiety, thereby affecting an individual’s physical and mental health. Simple and effective therapies for anxiety among quarantined populations need to be further explored. Horticultural activities can divert people's attention and alleviate negative emotions. Acupuncture is a conventional alternative therapy that has demonstrated efficacy in mood stabilization. The current study aimed to explore the clinical efficacy of combined Chinese and Western medicine therapies in alleviating anxiety among quarantined individuals during a pandemic.
Methods
In this prospective, randomised controlled trial (RCT), 150 patients with generalised anxiety disorder will be recruited from the Seventh Clinical College affiliated to Guangzhou University of Chinese Medicine. Eligible subjects will be randomly divided into the horticultural group (n = 50), intradermal acupuncture group (n = 50) and combined treatment group (n = 50). The horticulture group will engage in horticultural activity after basic treatment; the intradermal needle group will undergo intradermal needling after basic treatment; and the combined group will engage in horticultural activity and undergo intradermal needling after basic treatment. The treatments will be provided once a week for 8 weeks. The main outcome will be scores on the Hamilton Anxiety Scale (HAMA); secondary outcomes will include scores on the Self-Assessment Scale for Anxiety (SAS) and Pittsburgh Sleep Quality Index Scale (PSQI), serum indexes, and cortical excitability. All scales will be evaluated at baseline, at 2, 4, 6, and 8 weeks of treatment, and at follow-up; serological indicators and cortical excitability will be assessed at baseline and during week eight of treatment.
Discussion
The result of the experiment will help to clarify the therapeutic effects of horticultural therapy combined with intradermal needling on anxiety among isolated individuals and to elucidate the therapeutic mechanisms of this combined treatment among patients with anxiety. The purpose of this research is to eventually incorporate this combination approach into a treatment programme for anxiety, thereby significantly reducing the burden of mood disorders in the general population during public health emergencies.
Trial registration:
ClinicalTrials.gov ChiCTR2200066321. Registered on December 1, 2022
Survival Benefits of Primary Tumor Surgery in Diverse Cancer Types with Synchronous Bone Metastases: A Retrospective Real-World Analysis Using Propensity Score Matching from a 3P Medicine Perspective
Authors: Shi Bochong , Xu Peihang , Xu Lun , Cheng Mo , Wang Shuoer , Liang Chao , Huang Wending , Cai Weiluo , Yan Wangjun 
Published: December 2023

Abstract
Background: Bone metastasis (BM) is a common occurrence significantly impacting their quality of life and overall survival, and the role of primary site surgery (PTS) is also mentioned. However, the specific diagnostic and treatment model for PTS needs to be elucidated in order to transition from reactive medicine toward a step-by-step approach to predictive, preventive, and personalized medicine (PPPM). This study aims to investigate the potential survival advantages associated with PTS in patients with varying cancer types presenting concurrent BMs.
Methods: A comprehensive analysis was conducted on patients exhibiting exclusive BM, encompassing data from the Surveillance, Epidemiology, and End Results (SEER) database spanning 2010 to 2019. Specifically, we focused on BMs originating from multiple cancers, and patients were categorized into PTS group or its absence (No PTS). Employing propensity score matching (PSM), we meticulously compared the overall survival (OS) and cancer-specific survival (CSS) rates between these two cohorts. Additionally, we examined survival outcomes after patients experienced diverse surgical and treatment modalities. Furthermore, we conducted subgroup analysis to explore target populations suitable for PTS.
Results: 53,015 patients were encompassed within this study. Breast cancer, renal cell carcinoma, bladder cancer, and lung cancer patients with BM were more inclined to undergo PTS. Across different cancer types, the choice of surgical approach and extent of resection exhibited heterogeneity in survival prognosis. Substantial enhancement in survival was observed in patients presenting early-stage and lower-grade metastases upon undergoing PTS.
Converging Survival Trends in Non-Small Cell Lung Cancer Patients With and Without Brain Metastasis Receiving State-of-the-Art Treatment
Authors: Averbuch Itamar , Tschernichovsky Roi , Yust-Katz Shlomit , Rotem Ofer , Limon Dror , Kurman Noga , Icht Oded , Reinhorn Daniel , Moskovitz Mor , Hanovich Ekaterina , Benouaich-Amiel Alexandra , Siegal Tali , Zer Alona , Gal Omer 
Published: December 2023

Abstract
Introduction: Historically, patients with brain metastasis (BM) have been excluded from clinical trials investigating treatments for non-small cell lung cancer (NSCLC) due to their unfavorable prognosis. Advanced treatments have increased survival prospects for NSCLC patients with BM. This study evaluated the life expectancy of NSCLC patients with and without BM in the context of contemporary treatments.
Methods: Outcome data were collected for patients with advanced NSCLC attending a tertiary medical center between 2015-2020. Patients were stratified according to BM status and compared for overall survival (OS) using log-rank and Cox regression analyses.
Results: The cohort included 360 patients with NSCLC of whom 134 (37.2%) had BM. Most (95%) of cases of BM developed within the first two years: 63% at diagnosis, 18% during the first year, 14% during the second year. There was no significant difference in OS between patients without BM and those with BM (median 23.7 vs. 22.3 months, HR=0.97, p=0.82); patients with BM and a targetable or non-targetable mutation (40.2 vs. 31.4 months, HR=0.93, p=0.84, and 20.7 vs. 19.87 months, HR=0.95, p=0.75, respectively); and patients with symptomatic BM (23.7 vs. 19.8 months, HR=0.95, p=0.78). Treatment for BM (95% of patients) consisted of stereotactic radiosurgery or tyrosine kinase inhibitors, with corresponding intracranial control rates of 90% and 86%.
Conclusion: The results imply that the presence of BM has no impact on the prognosis of NSCLC. The practice of excluding NSCLC patients with BM from clinical trials warrants reconsideration.
Identification of Key Genes in Systemic Lupus Erythematosus through integrated bioinformatics
Authors: Yan Haiying , Zhang Zhongyi , Zheng Anmei , Jiang Huanyu 
Published: December 2023

Abstract
Background：Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unclear mechanisms, limiting treatment options. Our study identifies potential core genes of SLE and their clinical applicability.
Method：Using differential expression and weighted gene co-expression network analysis (WGCNA), we identified novel susceptibility modules and associated core genes. Examination of these genes through KEGG and GO analyses revealed their roles. Diagnostic performance of the core genes was evaluated using column line plot models and Receiver Operating Characteristic (ROC) curves. We also assessed the correlation between core genes and immune infiltration and used Mendelian randomization to determine the causal effect of GYPB on SLE.
Results：The gene co-expression network constructed through WGCNA identified 144 key genes associated with SLE. The column line graph model demonstrated strong predictive power for SLE risk, with its diagnostic effectiveness validated by the ROC curve. A causal relationship was established between the top five core genes and immune cell infiltration in SLE. A negative correlation was observed between the gene GYPB and SLE, suggesting that GYPB might serve as a potential therapeutic target.
Conclusion：This investigation provides new insights into SLE molecular mechanisms and potential therapeutic avenues.
Leptomeningeal Carcinomatosis and Brain Metastases in Gastroesophageal Carcinoma: a real-world analysis of Clinical and Pathologic Characteristics and Outcomes
Authors: Megid Thais Baccili Cury , Baskurt Zeynep , Ma Lucy X. , Barron Carly Christine , Farooq Abdul Rehman , Saltiel Marie Philippe , Wang Xin , Bach Yvonne , Ayoama Hiroko , Jang Raymond , Chen Eric , Veit-Haibach Patrick , Wang Ben , Kalimuthu Sangeetha , Cotton James , Wong Rebecca , Mesci Aruz , Elimova Elena 
Published: December 2023

Abstract
Background: Brain metastasis (BrM) and Leptomeningeal Carcinomatosis (LMC) are uncommon complications in gastroesophageal carcinoma (GEC) patients. These patients have a poor prognosis and are challenging to treat. We described the clinicopathologic features and outcomes in the largest cohort of Central Nervous System (CNS) metastasis in GEC patients.
Methods: single-center retrospective study of GEC treated from 2007 to 2021. Clinicopathologic characteristics and treatment modalities were reviewed. Survival was calculated from the date of CNS diagnosis until date of death/last follow-up using the Kaplan-Meier method. A multivariable Cox proportional hazards regression model was used.
Results: Of 3283 GEC patients, 100 (3.04%) were diagnosed with BrM and 20 with LMC (0.61%). Patients with known human epidermal growth factor receptor 2 (HER2) status (N= 48), 60% were HER2 positive (defined as IHC 3+ or IHC 2+/FISH+). Among LMC patients most were signet-ring subtype (85%), and only 15% (2/13) were HER2 positive. Median survival was 0.8; 3.8; and 7.7 months in BrM patients treated with best supportive care, radiation, and surgery, respectively (p< 0.001). In LMC, median survival was 0.7 month in patients who had best supportive care (7/20) and 2.8 months for those who had whole brain radiation therapy (p=0.008). Multivariate analysis showed worse outcomes in ECOG ≥2 (p=0.02), number of BrM ≥4 (p<0.001) and number of metastatic sites (p=0.004).
Conclusion: HER2 expression were enriched in patients with BrM, while it is uncommon in LMC. Patients treated with surgery followed by radiation had an improved OS in BrM and WBRT benefited patients with LMC.
Pharmaceutical company payments to Japanese breast cancer practice guideline
Authors: Murayama Anju , Higuchi Kenichi , Reddy Keerthana , Hinari Kugo , Senoo Yuki 
Published: December 2023

Abstract

Background:
The creation of breast cancer practice guidelines requires careful management of conflicts of interest (COIs). However, limited evidence is available regarding the specific landscape and fraction of financial relationships between pharmaceutical companies and the authors of The Japanese Breast Cancer Society Clinical Practice Guidelines for Breast Cancer,edition 2022 (JBCS2022).
Methods:
Using payment data publicly disclosed by major pharmaceutical companies in Japan, this study analysed the personal payments made to the authors of JBCS2022 between 2016 and 2020. We performed descriptive analyses on the payment data.
Results:
Of 149 JBCS2022 authors, 115 (77.2%) received at least one personal payment from pharmaceutical companies totaling $3,828,455 between 2016 and 2020. The average and median payment amounts per author were $25,772 (SD: $58,197) and $2,761 (IQR: $322‒$15,828), respectively. The total annual payments per JBCS2022 authors between 2016 and 2019 increased from $588,054 in 2016 to $967,802 in 2019. The JBCS2022 chairperson and vice-chairperson received $246,936 (4th highest) and $216,744 (5th highest) over the five years. More than 60% of personal payments to the JBCS2022 authors were not declared by the authors as they were below the declaration threshold set by the Japanese Breast Cancer Society. However, nine authors undeclared personal payments summing $594,615 even though these payments were higher than the thresholds.
Conclusion:
This study demonstrated that the majority of the Japanese breast cancer guideline authors received personal payments from the pharmaceutical companies. Furthermore, the majority of payments were not declared due to the less transparency COI policy.
Development of a dual cryogenic detection system for the forbidden non-unique β-decay spectrum study
Authors: Kim H.L. , Kim H.J. , Kim W.T. , Kim Y.D. , Kim Y.H. , Kim M.H. , Lee Y.C. , Nagorny S.S. , Shlegel V.N. , So J. 
Published: December 2023

Abstract
We present the development of a dual-detector system designed for investigating the spectral shape of forbidden non-unique beta decays. Two PbMoO4 scintillating crystals were carefully prepared for heat and light detection at milli-Kelvin (mK) temperatures. Notably, one crystal was synthesized using archaeological lead, while the other was composed of natural modern lead. The significance of employing two crystals lies in their identical dimensions and proximity, resulting in similar environmental background exposure. Their distinct internal radioactivities, particularly associated with 210Pb, introduce a distinguishing factor between the spectra measured in the two detectors. Our detection method includes achieving clear particle identification through the relative amplitudes of light and heat signals for both crystals. This report compares the electron-induced spectra within energy regions both below and above the endpoint of 210Bi beta decay. This comparative study provides valuable insights into an exact measurement of the 210Bi decay spectrum, forbidden non-unique beta decay.
Levosimendan ameliorates the scopolamine induced cognitive impairment via modulating pCREB/BDNF expression, cholinergic neurotransmission and neuroinflammation
Authors: Kolusu Aravinda Sai , Ganesh Grandhi Sandeep , Nagabhairava Manogna , Madhana Rajaram Mohan Rao , Konduri Prasad , Nemmani Kumar V.S , Samudrala Pavan Kumar 
Published: December 2023

Abstract

Levosimendan, an inotropic drug that potentiates ATP-dependent K+ channel and sensitise troponin-C for calcium. It has positive effects in neurodegenerative diseases like Parkinson’s disease and mild septic encephalopathy. However, its effect on Alzheimer's disease remains unclear. Hence, in this study, we have investigated the effect of levosimendan against scopolamine induced cognitive impairment in rats via behavioural tests (Y maze, water maze and novel object recognition test), cholinesterase enzymes, oxidative stress markers, amyloid-β plaques, inflammatory mediators, and neurotrophic factors analysis. In this study, rats were divided into five groups. The first and second groups were given with vehicle or levosimendan (100 µg/kg/day i.p.) throughout the study. The remaining groups were pre-treated with vehicle/Donepezil (3mg/kg/day i.p.)/Levosimendan (100 µg/kg/day i.p.) respectively. From day – 8 these groups were given with their respective drugs and Scopolamine (3 mg/kg., i.p.) with 1 hour time interval. Behavioral analysis was carried out to assess the learning and memory functions of rats after 30 min of scopolamine administration from day 8 to day 17. Levosimendan treated group significantly improves in number of spontaneous alterations and recognition ability in Y-maze and NOR test respectively. In addition, levosimendan inhibited scopolamine induced pathological changes such as increased levels of cholinesterase enzymes, Aβ accumulation, neuro inflammation and reduced levels of BDNF. In summary, these findings indicate that pre-treatment with levosimendan mitigates the scopolamine induced behavioural and biochemical changes.
Exploring Nursing Research Culture in Clinical Practice: Qualitative Ethnographic Study
Authors: Hwang Hyeyoung , De Gagne Jennie C , Yoo Leeho , Lee Miji , Jo Hye Kyung , Kim Ju-eun 
Published: December 2023

Background
Cultivating a positive research culture is considered the key to facilitating the utilization of research findings. In the realm of clinical nursing research, nurses conducting research may find the utilization of findings challenging due to the lack of a positive research culture.

Objective
This study aims to identify and describe the sociocultural context of nursing research in a clinical setting at a Korean tertiary hospital.

Methods
We included participant observation and ethnographic interviews with 6 registered nurses working in a medical-surgical unit in a Korean tertiary hospital who had experience conducting nursing research in clinical settings in this qualitative ethnographic study. The study was conducted from April 2022 to May 2022. Data analysis was conducted using Spradley’s ethnographic approach, which includes domain analysis, taxonomic analysis, componential analysis, and theme analysis, and occurred concurrently with data collection.

Results
The overarching theme identified for nursing research culture in clinical practice was the development of a driving force for growth within the clinical environment. This theme encompasses (1) balancing positive and negative influences in the research process, (2) fostering transformational change for both nurses and patients, and (3) promoting complementary communication among nurses.

Conclusions
Clinical research plays a vital role in nursing practice that requires a balance of supportive elements, such as patient-driven research questions and hospital research support, with practical challenges such as shift work and high work intensity. This study found that a positive clinical nursing research culture can serve as a unifying bridge, connecting researchers, patients, who serve as both the origin and ultimate beneficiaries of research, and hospitals that facilitate research endeavors. Future research should explore whether the themes derived from this study fully reflect a clinical nursing research culture comprising patients, nurses, and the hospital environment and determine what requirements are needed to establish such a nursing research culture.