bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ubuntu philosophy, values, and principles: An opportunity to do social work differently
Authors: Udah Hyacinth , Tusasiirwe Sharlotte , Mugumbate Rugare , Gatwiri Kathomi 
Published: January 2025

Summary Rising immigration and increasing cultural diversity globally highlight the need to decolonize social work and challenge the hegemony of Western-centric cultural and epistemological foundations. This article explores how Ubuntu philosophy can serve as a global decolonizing framework in social work education and practice. Using a reflective conceptual analysis process, we explored Ubuntu as an alternative paradigm for social work educators, researchers, practitioners, and students. Ubuntu's core values—relationality, collective responsibility, communal accountability, social justice, recognition, and reciprocity—offer a unique framework that sets it apart from other philosophies. Findings We propose embracing Ubuntu’s core principles to enrich social work knowledge, theories, and practice, decolonizing and addressing gaps left by Western approaches. We argue that integrating the core values of Ubuntu philosophy can significantly enhance social work practices. Applications This article contributes to ongoing discussions on decolonization and the importance of epistemological diversity in redefining social work and exploring new ways of practice.
Youth perspectives on health, well-being, and sustainable development: A photovoice study
Authors: Chang Elvi , Turunen Päivi , Sjöberg Stefan , Rambaree Komalsingh 
Published: January 2025

Summary This study examined how youth perceive their health, well-being, and working-life capacity in relation to ecosocial work within the context of sustainable development. Data were gathered using the photovoice method with two discussion groups, including 11 15- to 19-year-olds from Gävle, Sweden. Inductive thematic analysis was used to create themes from the data. The Having-Doing-Loving-Being model of well-being by Helne and Hirvilammi, and Zimmerman's psychological empowerment were applied to interpret the findings. Findings The findings indicate that the participants saw sustainable development as a “buzz concept” with low relevance for their health and well-being. The participants perceived health and well-being as “feeling good” on an individual level, with more emphasis on doing activities for self-actualization and less on working-life capacity or environmental issues. They expressed no interest in disseminating the results of their discussions to other stakeholders for collective empowerment and social mobilization, which is a crucial part of the photovoice method. The results also indicate an individualistic and hedonic life orientation among the participants. Applications The study provides social work and its practitioners an understanding of the importance of enabling youth voices and linking youth personal and collective well-being with sustainable development. The study also offers an understanding of well-being within social work discourse that incorporates environmental stewardship alongside youth's personal fulfilment.
Continuous atrial fibrillation monitoring using a wearable smartwatch: Using long-term Holter as reference
Authors: Pan Yannan , Chen Erdong , Jie Shihui , Huo Dongbo , Ding Zhongru , Zhou Jing , Jiang Jie , Li Jianping , Huo Yong 
Published: January 2025

Background Wearables satisfactorily detect atrial fibrillation (AF) longer than 1 hour. Our study aims to evaluate smartwatch performances for long-term AF monitoring, including AF with short durations. Methods This prospective study enrolled AF patients from 2020 to 2023. Diagnostic efficacy of the Amazfit smartwatch, with AF-identifying algorithms from photoplethysmography (PPG) and single-lead electrocardiogram (ECG), was compared with a 7-day Holter. Primary analysis included smartwatch diagnostics to identify AF longer than 5 minutes. Secondary analyses evaluated smartwatch performances under different settings and compared AF burdens between the smartwatch and Holter. Results The study analyzed 72 patients (48 males, mean age 65.4 ± 8.5) with 914 AF episodes lasting 834.7 hours, including 142 longer-than-5-minute AF episodes. Smartwatch recording time was 8927.6 hours. By individual, sensitivities and specificities of AF longer than 5 minutes were 100.0% and 83.7% for PPG and 89.7% and 67.4% for the ECG algorithm. Positive and negative predictive values were 94.9% and 99.9% for PPG and 77.6% and 99.8% for ECG. Optimal AF durations to be identified by PPG and ECG algorithms were 1.358 and 16.708 minutes. Smartwatch performances varied across AF durations and between day-time and night-time. Strong correlations (PPG: ρ = 0.877; ECG: ρ = 0.769) and excellent agreements (PPG: ICC = 0.976; ECG: ICC = 0.927) were found between AF burdens calculated from smartwatch and Holter. Conclusions Compared with long-term Holter, the wearable smartwatch had satisfying qualitative and quantitative diagnostic performances for continuous AF monitoring. Susceptibility to false positives led to modest specificity. Smartwatch performances were affected by AF durations and time periods. Registration ChiCTR2000040035.
Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure
Authors: Liu Songhao , Yan Juan , Gao Mengyu , Yang Hongxia 
Published: January 2025

Abstract
Recently, the incidence rate and mortality of various acute or chronic vascular occlusive diseases have increased yearly. As one of the most effective measures to treat them, vascular stents have been widely studied by researchers, and presently, the most commonly used is a drug-eluting stent, which reduces the process of rapid endothelialization because the drug is not selective. Fortunately, with the discovery and exploration of micro–nanostructures that can regulate cells selectively, reducing the incidence of "intravascular restenosis" and achieving rapid endothelialization simultaneously are possible through a special structure that cannot only improve endothelial cells (ECs), but also inhibit smooth muscle cells (SMCs). Therefore, this paper mainly introduces the preparation methods of micro–nanostructures used in the past, as well as the detection methods of EC and SMC. Then, the various functions of different dimensional structures for different cells are summarized and analyzed. Finally, the application of micro–nanostructure in future stent materials is summarized and proposed.
Effects of movement behaviors on preschoolers’ cognition: a systematic review of randomized controlled trials
Authors: Pacheco Catalina , Culkin Victoria , Putkaradze Amelia , Zeng Nan 
Published: January 2025

Abstract

Background
Movement behaviors, including physical activity (PA), sedentary behavior (SB), and sleep, are fundamental to early childhood development. These behaviors interact dynamically within a 24-hour period, creating a complex balance that influences not only physical health but also cognitive and emotional well-being in young children. While the physical health benefits of movement behaviors are well-documented, systematic evaluations of how interventions targeting these behaviors affect cognitive development in preschool-aged children remain limited.

Methods
This review was guided through PRISMA 2020 guidelines. We conducted a systematic review of randomized controlled trials (RCTs) to evaluate the impact of interventions targeting PA, SB, and sleep on cognitive outcomes in preschool-aged children. A comprehensive search was performed across five databases: PubMed, PsycInfo, Web of Science, Embase, and CINAHL, covering studies published between January 2000 and December 2023. Eligible studies were those that focused on at least one movement behavior, had a minimum intervention duration of four weeks, and assessed cognitive development as a primary outcome. The cognitive outcomes evaluated included executive function, attention, memory, and other key domains critical to early childhood development, such as language, processing speed, and social cognition.

Results
Twenty-two RCTs (14 individual, 8 cluster) met the inclusion criteria. Of these, 21 studies focused on PA, while only one targeted SB, and none specifically addressed sleep or combined movement behaviors. PA interventions, particularly those involving cognitively engaging activities, significantly improved cognitive domains such as executive function, inhibition, and attention, with effect sizes ranging from moderate to large (Cohen’s d > 0.5). The SB-focused study did not report significant cognitive improvements. A clear gap exists in understanding the effects of sleep and multi-behavior interventions on cognitive outcomes.

Conclusions
Cognitively engaging PA interventions demonstrated the largest effects, while motor skill-focused and general PA programs produced moderate to smaller gains. Evidence on SB and sleep interventions remains limited, with no studies exploring the combined effects of these three movement behaviors. Future research should focus on integrated interventions that address PA, SB, and sleep to achieve a more comprehensive understanding of their collective impact on cognitive development in early childhood.

Trial registration
This study was registered with PROSPERO under the registration number CRD42023479156.
Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences
Authors: Møller Pål , Ahadova Aysel , Kloor Matthias , Seppälä Toni T. , Burn John , Haupt Saskia , Macrae Finlay , Dominguez-Valentin Mev , Möslein Gabriela , Lindblom Annika , sunde Lone , Winship Ingrid , Capella Gabriel , Monahan Kevin , Buchanan Daniel D. , Evans D. Gareth , Hovig Eivind , Sampson Julian R. 
Published: January 2025

Abstract
Carcinogenesis encompasses processes that lead to increased mutation rates, enhanced cellular division (tumour growth), and invasive growth. Colorectal cancer (CRC) carcinogenesis in carriers of pathogenic APC (path_APC) and pathogenic mismatch repair gene (path_MMR) variants is initiated by a second hit affecting the corresponding wild-type allele. In path_APC carriers, second hits result in the development of multiple adenomas, with CRC typically emerging after an additional 20 years. In path_MLH1 and path_MSH2 carriers, second hits lead to the formation of microscopically detectable, microsatellite unstable (MSI) crypts, from which CRC develops in about half of carriers over their lifetime, often without progressing through a diagnosable adenoma stage. These divergent outcomes reflect the distinct functions of. the APC and MMR genes. In path_MLH1 and path_MSH2 carriers, a direct consequence of stochastic mutations may be the occurrence of invasive growth before tumour expansion, challenging the paradigm that an invasive cancer must always have an non-invasive precursor. In contrast to other path_ MMR carriers, path_PMS2 carriers who receive colonoscopic surveillance exhibit minimal increase in CRC incidence. This is consistent with a hybrid model: the initial mutation may cause an adenoma, and the second hit in the wild-type PMS2 allele may drive the adenoma towards become cancerous with MSI. Since all mutational events are stochastic, interventions aimed at preventing or curing cancer should ideally target the initial mutational events. Interventions focused on downstream events are external factors that influence which tumour clones survive Darwinian selection. In Lynch Syndrome, surveillance colonoscopy to remove adenomas may select for carcinogenetic pathways that bypass the adenoma stage.
TERT de novo mutation-associated dyskeratosis congenita and porto-sinusoidal vascular disease: a case report
Authors: Yu Ge , Xin Guijie , Liu Xu , Li Wanyu , Shao Chen , Gao Runping 
Published: January 2025

Abstract

Background
Dyskeratosis congenita is a rare genetic disease due to telomere biology disorder and characterized by heterogeneous clinical manifestations and severe complications. “Porto-sinusoidal vascular disease” has been recently proposed, according to new diagnostic criteria, to replace the term “idiopathic non-cirrhotic portal hypertension.” TERT plays an important role in telomeric DNA repair and replication. A TERT c.2286 + 1G/A mutation in a splicing consensus site was identified in a patient with pulmonary fibrosis. Recently, a pathogenic de novo TERT c.280A > T variant was associated with diffuse lung disease in an infant.

Case presentation
A 16-year-old Han male patient experienced unexplained black stool for 7 days, accompanied by dizziness and fatigue. On examination, there were mesh pigmentations on the exposed areas of the skin on both hands and feet. Laboratory testing revealed moderate hemorrhagic anemia and mild elevation of alanine aminotransferase. A computed tomography scan showed portal hypertension, esophageal and gastric varices, and splenomegaly. The liver stiffness measurement by FibroScan was 6.0 kPa. Liver biopsy revealed typical features of porto-sinusoidal vascular disease. Whole exome sequencing identified a heterozygous TERT c.2286 + 1G > A de novo mutation and quantitative polymerase chain reaction revealed very short telomeres (less than the first percentile for his age). The patient was diagnosed as TERT de novo mutation-related dyskeratosis congenita and porto-sinusoidal vascular disease. He underwent esophageal and gastric variceal ligation treatment and received a carvedilol tablet (12.5 mg) every morning. After 6 months, he has moderate iron deficiency anemia and has started receiving polysaccharide iron complex therapy.

Conclusion
When discovering reticular rash and unknown portal hypertension, it is necessary to perform whole exome sequencing and chromosome length testing to clarify the possibility of dyskeratosis congenita/telomere biology disorder with porto-sinusoidal vascular disease.
Therapeutic efficacy of intra-articular injection of human adipose-derived mesenchymal stem cells in a sheep model of knee osteoarthritis
Authors: Lei Jigang , Chen Xingyi , Xie Haohao , Dai Yuhao , Chen Zhongjin , Xu Liang 
Published: January 2025

Abstract

Background
Mesenchymal stem cells have great potential for repairing articular cartilage and treating knee osteoarthritis (KOA). Nonetheless, little is known about the efficacy of human adipose-derived mesenchymal stem cells (haMSCs) for KOA in large animal models.

Methods
This study evaluated the therapeutic efficacy of haMSCs in knee articular cartilage repair in a sheep model of KOA. haMSCs were isolated, cultured, and characterized. KOA was surgically induced by anterior cruciate ligament transection and medial meniscectomy, followed by intra-articular injection of saline (negative control group) or haMSCs (haMSC group) into the right knee joint at 6 and 9 weeks after surgery. Sheep were sacrificed 21 weeks after surgery, and samples (whole knee joints, femoral condyles, and tibias) were collected, processed, and analyzed. Changes in knee articular cartilage were assessed by magnetic resonance imaging, micro-computed tomography, macroscopic analysis, histology, and immunohistochemistry.

Results
KOA caused the degeneration of the medial femoral condyle in the sheep model of KOA. Conversely, haMSCs repaired chondral defects and increased the thickness of knee articular cartilage.

Conclusions
These data suggest that the intra-articular injection of haMSCs can effectively repair articular cartilage defects in the knee.
Fezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials
Authors: Allam Abdallah R. , Alhateem Mohamed Salah , Mahmoud Abdelrahman Mohamed 
Published: January 2025

Abstract

Background
Postmenopausal women are more likely to experience vasomotor symptoms (VMS), such as heat sensation and sweating. Recent trials have investigated fezolinetant in the treatment of VMS in postmenopausal women. Our study aims to conduct a meta-analysis of these trials in order to estimate fezolinetant’s effectiveness and safety in the management of VMS in postmenopausal women.

Method
We searched Cochrane, PubMed, Scopus, and Web of Science for all published randomized controlled trials. Review Manager Software was used for the meta-analysis. The quality of evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework.

Results
Our study contained five trials with 3295 individuals with a mean age of 54.4 years. The frequency of VMS was significantly lower in the fezolinetant group compared to the placebo group [MD = − 2.42, 95% CI (− 2.81, − 2.04), P < 0.00001]. Additionally, when compared to the placebo group, the severity of VMS was significantly lower in the fezolinetant group [SMD = − 0.36, 95% CI (− 0.46, − 0.26), P < 0.00001]. Furthermore, there was no significant difference in the incidence of treatment-emergent adverse events (TEAEs) between the fezolinetant group and the placebo group [RR = 1.02, 95% CI (0.97, 1.07), P = 0.51].

Conclusion
Fezolinetant is efficient and well-tolerated in the treatment of postmenopausal women with VMS.
Real-world use of tafasitamab preceding CD19-directed chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B-cell lymphoma
Authors: Epperla Narendranath , Nastoupil Loretta J. , Feinberg Bruce , Galvin John , Pathak Prathamesh , Amoloja Theresa , Gentile Danielle , Saverno Kim 
Published: January 2025

Abstract
Potential CD19 antigen loss following CD19-directed therapy has raised concerns over sequential use of these therapies. Tafasitamab, a CD19-targeting immunotherapy, combined with lenalidomide, is approved for relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL) treatment in adults ineligible for autologous stem cell transplantation. This retrospective analysis examined characteristics and outcomes of adults with R/R DLBCL who received tafasitamab preceding CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy in a real-world setting. Nine patients received tafasitamab and lenalidomide immediately preceding CAR-T. Median (first quartile [Q1]–third quartile [Q3]) follow-up time since tafasitamab initiation was 26.1 (18.0–28.0) and after CAR-T was 9.3 (1.9–16.7) months. Of the 9 patients, 4 had complete response, 4 had partial response, and 1 had stable disease following tafasitamab; all discontinued tafasitamab due to disease progression. Median (Q1–Q3) tafasitamab therapy duration was 11.0 (8.1–14.1) months. Three patients had CD19 testing following tafasitamab discontinuation, and all tests were positive. Median (Q1–Q3) time from tafasitamab discontinuation to CD19 testing was 7 (6–9) days. Among the 9 patients, median (Q1–Q3) time from tafasitamab discontinuation to CAR-T administration was 3.2 (2.3–3.6) months. Four patients had complete response, 3 had partial response, and 1 had progressive disease as best response to CAR-T; 1 patient had data unavailable. This small real-world analysis demonstrated disease response to CAR-T therapy and detectable CD19 expression following tafasitamab treatment, adding to literature investigating treatment outcomes associated with sequential use of anti-CD19 therapies in patients with R/R DLBCL.
CBD for pets: navigating quality assurance, safety standards, and marketing strategies
Authors: Rideout Hannah , Cook Alasdair J. C. , Whetton Anthony D. 
Published: January 2025

Abstract
As the human cannabinoid (CBD) market grows, there is an inevitable transfer of the same or similar products into the veterinary sector. Advances in veterinary medicine and care of companion animals has led to extended life expectancy and consequently, there is an increased incidence of age-related chronic conditions that compromise quality of life. CBD products may alleviate these conditions. Research into CBD for companion animal species is on the rise, however, we found that there are no licensed veterinary CBD products available in the market due to a lack of appropriate testing and/or data. Here we outline the data that is available and show that the regulatory, and safety considerations around these products needs further consideration and this encompasses many products currently available on the market. Changes in regulations and further research for quality assurance are paramount to distribution of safe and applicable products for companion animals.
Impact of ABO gene polymorphism and von Willebrand factor on genetic susceptibility to acute lymphoblastic leukemia in Egyptian pediatric patients
Authors: Salim Elsayed I. , Shaaban Ahmed N. , Seleem Amal K. , Attia Zeinab I. 
Published: January 2025

Abstract

Background
Acute lymphoblastic leukemia (ALL) is the most common malignancy affecting children. The ABO blood group system and von Willebrand factor (VWF) have been associated with altering cancer risk, but few studies have examined their relationship with pediatric ALL. This study investigated the association between ABO gene polymorphism, VWF levels, ABO blood groups, and ALL risk in Egyptian pediatric patients.

Methods
Seventy-two ALL patients and 36 healthy controls were ABO phenotyped and genotyped for the ABO rs2519093 polymorphism using PCR–RFLP. VWF antigen levels were measured by ELISA.

Results
The CC genotype and C allele frequencies were significantly higher in ALL patients compared to controls (p < 0.001) and increased ALL risk by 12.94-fold and 7.63-fold, respectively. VWF levels were significantly higher in ALL patients versus controls overall (p = 0.006) and in the A, B, and O blood groups individually. After adjusting for VWF levels, the O, A, and B blood groups increased ALL risk 87.95-fold, 15.95-fold, and 8.77-fold, respectively, compared to AB.

Conclusion
The ABO C allele and O, A, and B blood groups are associated with increased pediatric ALL susceptibility in Egyptian patients, potentially through elevated VWF levels. These findings highlight ABO gene polymorphisms and blood groups as possible risk factors for ALL development.
Peptide hormones in plants
Authors: Zhang Zhenbiao , Han Huibin , Zhao Junxiang , Liu Zhiwen , Deng Lei , Wu Liuji , Niu Junpeng , Guo Yongfeng , Wang Guodong , Gou Xiaoping , Li Chao , Li Chuanyou , Liu Chun-Ming 
Published: January 2025

Abstract
Peptide hormones are defined as small secreted polypeptide-based intercellular communication signal molecules. Such peptide hormones are encoded by nuclear genes, and often go through proteolytic processing of preproproteins and post-translational modifications. Most peptide hormones are secreted out of the cell to interact with membrane-associated receptors in neighboring cells, and subsequently activate signal transductions, leading to changes in gene expression and cellular responses. Since the discovery of the first plant peptide hormone, systemin, in tomato in 1991, putative peptide hormones have continuously been identified in different plant species, showing their importance in both short- and long-range signal transductions. The roles of peptide hormones are implicated in, but not limited to, processes such as self-incompatibility, pollination, fertilization, embryogenesis, endosperm development, stem cell regulation, plant architecture, tissue differentiation, organogenesis, dehiscence, senescence, plant-pathogen and plant-insect interactions, and stress responses. This article, collectively written by researchers in this field, aims to provide a general overview for the discoveries, functions, chemical natures, transcriptional regulations, and post-translational modifications of peptide hormones in plants. We also updated recent discoveries in receptor kinases underlying the peptide hormone sensing and down-stream signal pathways. Future prospective and challenges will also be discussed at the end of the article.