bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Atypical shaped (2+1) dimensional solitons in optical nanofibers
Authors: Mukherjee Abhik 
Published: November 2023

Abstract
In this article, some atypical topological soliton solutions of Kundu-Mukherjee-Naskar (KMN) equation have been derived. Some exact solutions of different shapes like U shaped soliton, W shaped soliton, three hump soliton, periodic soliton etc. have been obtained. These unusual shapes of the topological solitons on x− y plane occur due to the occurrence of an arbitrary nonlinear function in their argument. This solutions are quite uncommon in the field of integrable systems that may enrich the field of nano fiber optics.
WITHDRAWN: Dynamics of free surface shock waves for a saturated superfluid Helium film on a nanopore substrate
Authors: Mukherjee Abhik 
Published: November 2023

Abstract
We have explored a saturated (∼ 10−6cm) superfluid 4He film adsorbed on a nano pore substrate material. We have considered a weak and localized superfluid flow into the porous substrate and investigated its effect on the shock wave dynamics at the surface. The free surface wave dynamics of the superfluid film follows forced Korteweg de Vries (KdV) equation. For a specific choice of nontrivial boundary condition at z = 0, the nonlinear evolution equation turns into Korteweg de Vries-Burger equation having a shock wave solution. Such kind of analytical treatment using shallow water superfluid hydrodynamics is new in this field and may generate further research.
Therapeutic effect of fully human anti-Nrp-1 antibody in non–small cell lung cancer
Authors: Zhang Bo , Liu Qin , Li Lin , Hu Zhi , Guo Xiyuan , Ye Yingchun , Xu Wenfeng , Liao Xiaoyu , Nian Siji , Yuan Qing 
Published: November 2023

Abstract
While immune checkpoint inhibitors have changed the treatment paradigm for non–small cell lung cancer (NSCLC), not all patients have experienced their benefits. Hence, there is a pressing need to explore novel immune checkpoint inhibitors. Neuropilin-1 (Nrp-1) represents a distinct immune checkpoint capable of exerting antitumor effects through CD8+ T cells. It also serves as a T-cell memory checkpoint that regulates long-term antitumor immunity. However, its role in NSCLC remains unclear. In this study, we aimed to elucidate the increased expression of Nrp-1 on tumor-infiltrating lymphocytes CD8+ T cells within tumor tissues from patients with lung adenocarcinoma. We screened and constructed of high affinity full-length anti-Nrp-1 IgG1 antibody from a constructed high-capaci4ty fully human single chain fragment variable (scFv) phage library. This novel anti-Nrp-1 IgG1 antibody demonstrated the ability to restore depleted CD8+ T cells in malignant pleural fluid in vitro. Furthermore, it exhibited the capacity to kill target cells through peripheral blood mononuclear cells(PBMCs). Importantly, treatment with the anti-Nrp-1 antibody led to a significant reduction in tumor volume in an immune-systemic humanized mouse model of lung cancer. These findings collectively suggest the promising potential of 53-IgG1 as an effective Nrp-1-targeting agent in the immunotherapy of NSCLC.
The Refractory Tertiary Hyperparathyroidism Presenting With Retro- Orbital Brown Tumor: a Case Report
Authors: Uysal Cihan , Yilmaz Tugba , Ozkan Hamiyet , Canoz Ozlem , Tokgoz Bulent 
Published: November 2023

Abstract
Background: Tertiary hyperparathyroidism describes the autonomous and excessive secretion of parathyroid hormone (PTH) by the parathyroid glands after longstanding secondary hyperparathyroidism in chronic kidney disease. Brown tumors are a sign of uncontrolled hyperparathyroidism. In this case, we have reported a refractory and destructive hyperparathyroidism storm. Also, it presented with atypical onset and unexpected adenoma location.
Case presentation: A 37-year-old man was diagnosed with end-stage kidney disease 22 years ago. He has been undergoing dialysis treatment since that time. Recently, he was admitted to the ophthalmology department due to the unilateral anterior bulging of the right eye and drooping of the eyelid. Any extra finding was not determined on physical examination. Magnetic resonance imaging exhibited an extraconal mass lesion located in the right orbital posterior superolateral position. Computerized tomography scans considered expansile bone lesion with peripheral calcification and originating from the sphenoid wing. The bone mass lesion was resected via craniotomy due to the compressive effect. The pathological findings were consistent with brown tumors. Plasma intact PTH level was 4557 pg/mL. The patient notified that he underwent parathyroidectomy and two leg fractures operation in a medical query. Parathyroid scintigraphy determined three distinct foci consistent with adenomas and one of them was in mediastenum. Second parathyroidectomy was recommended to the patient but the patient refused surgery. Despite his medication and dialysis regimen being revised, PTH levels were maintained at higher levels in follow-up.
Conclusions: We presented a hyperparathyroidism case that was resistant to all treatments and exhibited all the severe complications in a long-term dialysis patient. Furthermore, this case has revealed the importance and difficulty of secondary hyperparathyroidism management.
Prognostic Significance of Inflammatory and Nutritional Index for Serous Ovary Cancer
Authors: Han Yan , Lv Weiqing , Guo Jianfei , Shang Yun , Yang Fan , Zhang Xiaomin , Xiao Keyuan , Zong Liang , Hu Wenqing 
Published: November 2023

Abstract
Background: The prognosis of cancer patients were related with Onodera’s prognostic nutritional index (OPNI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and systemic immune-inflammatory index (SII). The purpose of this study is explored the prognostic value of NLR, PLR, SII and OPNI for serous ovary cancer (SOC).
Patients and Methods: We retrospectively analyzed the cases of 133 patients with SOC at our institution from 2014 to 2021.Overall survival (OS) was analyzed by the Kaplan-Meier method. We performed a multivariate analysis using the Cox proportional hazard regression model to determine the independent prognostic indicators for SOC.
Results: The results revealed that the optimal cut-off points of NLR, PLR, SII and OPNI were 2.3, 224.4, 747.5 and 45.5, respectively. The comparative study found that there were differences in treatment way, tumor stage, Lymph node metastasis, Albumin, NLR, PLR, SII between the high-score and low-score OPNI groups, while other indicators are not irrelevant. And OPNI, NLR, PLR, SII were related with OS, which the value of OPNI was positively correlated with OS, whereas the NLR, PLR, SII was negatively correlated with OS. The analytic result showed that OPNI was regarded as greater prognostic indicator for SOC.
Conclusion: Our study found that the OPNI, NLR, SII could be a predictive and prognostic parameter for SOC.
A systematic review and meta-regression on international trends in the incidence of ulcerative colitis in children and adolescents associated with socioeconomic and geographic factors
Authors: Weidner Jens , Kern Ivana , Reinecke Ines , Bathelt Franziska , Manuwald Ulf , Henke Elisa , Zoch Michele , Rothe Ulrike , Kugler Joachim 
Published: November 2023

Abstract
Background: The incidence of ulcerative colitis (UC) among children and adolescents is rising globally, albeit with notable discrepancies across countries. This systematic review and meta-analysis aims to provide a comprehensive overview of the incidence rates of pediatric UC in various countries and explore potential influencing factors.
Methods: A systematic literature search was conducted in PubMed and EMBASE (via OVID) for studies published between January 1, 1970, and December 31, 2019. Additionally, a manual search was performed to identify relevant systematic reviews. Meta-analyses and meta-regressions were employed to determine the overall incidence rate and examine potential factors that may influence it.
Results: A total of 66 studies were included in the qualitative analysis, while 50 studies were used for meta-analysis and meta-regression. Our analysis showed significant differences in the incidence rates of pediatric UC across different geographic regions, with no discernible global temporal trend. In addition, our meta-regression analysis showed that geographic location and socioeconomic factors significantly influenced the incidence of UC.
Conclusions: Our findings indicate a rising incidence of pediatric UC in numerous countries since 1970, but with significant geographical variation, potentially presenting challenges for respective healthcare systems. We have identified geographic and socioeconomic factors that contribute to the observed heterogeneity in incidence rates. These findings provide a foundation for future research and health policies, aiming to tackle the growing burden of UC among children and adolescents.
Design of a High-Gain N-path Filter with Harmonic Rejection
Authors: Song Shuxiang , Liu Changping , Jiang Pinqun , Cen Mingcan 
Published: November 2023

Abstract
N-path filters have gained widespread utilization in wireless communication systems. However, the long-standing challenges of poor harmonic rejection ability and excessive signal attenuation have hindered their effectiveness. To address these problems, we propose an innovative N-path filter design boasting elevated harmonic rejection and gain characteristics. Our filter employs a high-gain, low-noise amplifier (LNA) as a precursor and incorporates a transconductance amplifier for the weighted fitting of sinusoidal signals. Through SMIC180nm process simulation, we demonstrate the filter's tunability within the range of 800MHz to 1.2GHz, with a third harmonic rejection and fifth harmonic rejection of 61dB and 67dB, respectively. The gain is 21dB, the noise figure is 8—9dB, and IIP3 is -6.2 dBm. Our design provides a significant improvement over traditional N-path filters and has promising potential for practical applications.
Limitations of Theory of Mind Defenses against Deception in Multi-Agent Systems
Authors: Piazza Nancirose , Behzadan Vahid , Sarkadi Stefan 
Published: November 2023

Abstract
The presence of deceptive agents within a multi-agent system can exert a detrimental influence on the performance and stability ofother agents in shared environments. In multi-agent interactions, the utilization of Theory of Mind (ToM) has become a considerable mech-anism for defenses against deception where it can possibly provide defenses with robustness and resilience to adverse effects against diverseforms of deception. ToM is the cognitive process through which an agent ascribes states to other agents, encompassing beliefs, objec-tives, intentions, desires, or any other characteristic. This paper investigates into the effectiveness and inherent limitations of employ-ing ToM-based defenses. We leverage stochastic games and Bayesian games, specifically highlighting formulations of Multi-Agent Reinforce-ment Learning (MARL) to establish the boundaries of ToM as a defense.
Exploring the Mechanism of Epimedium on Osteonecrosis of the Femoral Head through Network Pharmacology
Authors: Qi Yuxin , Hu Wei , Meng Chenyang , Jiang Enze , Ge Zhe , Wang Pei , Wang Jianzhong 
Published: November 2023

Abstract
BACKGROUND: Traditional Chinese Medicine (TCM) has consistently demonstrated promise in the prevention and management of ONFH. Epimedium, historically revered in Chinese medicinal recipes, has been utilized for mitigating conditions such as osteonecrosis and symptoms of kidney yang deficiency.
OBJECTIVE: This study aimed to forecast the drug targets and associated pathways through which Epimedium exerts its therapeutic effects against osteonecrosis of the femoral head. Additionally, we sought to delve deeper into its mechanism at the molecular level.
METHODS: In this study, we identified the active constituents and targets of Epimedium using the TCMSP database. The GEO database (with accession number GSE123568) was consulted to pinpoint targets associated with SONFH. Differential gene expression was visually represented through volcano and heat maps, crafted using the R software. GO and KEGG analyzes of these target genes were also subsequently performed using R software.
RESULTS: Five pivotal target genes were identified: PTGS2, KCNH2, BCL2L1, ABCG2, and E2F2. An exhaustive topological analysis was performed encompassing eight pathways and three genes.
CONCLUSION: This study elucidates the fundamental constituents, specific targets, and molecular pathways that underlie the effectiveness of Epimedium in the treatment of osteonecrosis of the femoral head.
Exploring Temporal Context in Human Pose Estimation: Benefits of 2D vs. 3D Input Data
Authors: Korbel Erik , Skorvankova Dana 
Published: November 2023

Abstract
The human body pose estimation is a challenging task that has been tackled by many different approaches over the last decades. The importance of solving this problem is rooted in an ability to automatically identify the pose of a subject in visual data. Even though numerous methods have been proposed to address the task, there is still ambiguity over what input data format is more efficient to use. Moreover, studies have shown that incorporating temporal information can be beneficial in one setting while leading to excessive computational complexity in others. In this paper, we investigate the effect of spatio-temporal context on the accuracy of the final estimations in end-to-end pose estimation methods, most importantly, whether it offers any additional value over the single-frame pose data. Furthermore, to address the question of the appropriate input data format, we compare experiments using the most widely used 2D and 3D visual input data structures.
Synthetic Routes and Pharmacological Activities of Purine Derivatives: A Review
Authors: Benkirane Soukaina , Misbahi Houria , Boudkhili Meriem , Rodi Youssef Kandri , Sebbar Nada Kheira , Essassi El Mokhtar 
Published: November 2023

Abstract:
The Purine moiety is regarded as the ubiquitous nitrogen-containing heterocycle
in nature and is recognized as a privileged scaffold in medicinal chemistry. Moreover, the
purine derivatives are heterocyclic aromatic compounds consisting of conjoined pyrimidine
and imidazole moieties. Purine derivatives are involved in various metabolic processes as
cofactors associated with a wide variety of enzymes and receptors. Therefore, many synthetic
ways to obtain purine derivatives were developed using different reagents such as pyrimidine,
imidazole, and some acyclic precursors. This article review focuses on the synthetic
methodologies of purine derivatives from its first synthesis in the 19th century to this last
decade and also reports a variety of proven pharmacological applications for the purine derivatives.
This review offers a panoply of synthetic routes that medicinal and organic chemistry
researchers can use in the preparation and design of new purine derivatives.
Complications and Hazards Associated with Body Piercing: A Narrative Review
Authors: Karimi Ebrahim , Nouri Majid , Hejripoor Seyed Zia , Darvishi Mohammad 
Published: November 2023

Objectives::
The increasingly widespread practice of piercings is often accompanied by
complications and hazards which are constantly increasing. Therefore, it seems necessary to pay
attention to the non-negligible risks that these practices entail and to the possibilities of reducing
them. Hence, this study was conducted to help raise awareness of the complications and hazards
associated with body piercing as a growing type of body modification practice.

Methods::
Studies were searched in the PubMed database and the Google Scholar engine using the
keywords, often in combination, including body piercing, body modification, complications, and
infection. The searches were limited to post-2000. Studies without limitations on their types were
included in this study.

Results::
The most important complications are infection, bleeding, trauma, allergy, and scarring.
Infection is the most common complication which occurs in individuals after piercing. A wide
spectrum of bacterial and viral infections may occur. Allergic manifestations are not uncommon,
with the risk that sensitization thus acquired may have subsequent harmful consequences.

Conclusions::
Educating people and health care professionals by conducting more studies to better
understand the complications of body piercing can be a solution to reduce health problems related
to body piercing.
An eHealth Prevention Program for Substance Use, Sexual Assault, and Sexual Risk Behaviors for Adolescents in Primary Care: Pilot Feasibility Randomized Controlled Trial of Teen Well Check
Authors: Gilmore Amanda K , Fortson Kennicia , Mullican K Nicole , García-Ramírez Grisel , Hutchins Anna , Bartlett Alyssa M , Gooding Holly C , Wallis Elizabeth , Levy Sharon , Ruggiero Kenneth J , Kaysen Debra , Danielson Carla Kmett , Platner Robert , Hartman April , Self-Brown Shannon 
Published: November 2023

Background
Substance use, sexual assault, and sexual risk behaviors are common among adolescents and are interrelated. Nearly 1 in 5 adolescents use substances before sexual encounters, placing these young people at risk for both sexual assault and sexual risk behaviors. Primary care visits present a unique opportunity to address multiple health risk behaviors.

Objective
Teen Well Check is a web-based integrated prevention program for substance use, sexual assault, and sexual risk behaviors with demonstrated usability and acceptability among patients and providers. The aim of this study was to conduct a pilot randomized controlled trial to assess feasibility.

Methods
Adolescents (n=123) aged 14 to 18 years from diverse backgrounds were recruited from primarily Medicaid-serving pediatric primary care clinics. Participants completed a baseline survey; were randomized to receive Teen Well Check or an assessment-only control; and completed 1-, 3-, and 6-month follow-up surveys. Feasibility was assessed in terms of recruitment and retention rates. Preliminary changes from baseline to follow-up periods were examined separately in the Teen Well Check and control conditions.

Results
We recruited 123 participants (Teen Well Check: n=61, 49.6%; control: n=62, 50.4%). Of the 61 participants assigned to the Teen Well Check condition, 55 (90%) completed the full program and viewed all intervention content. Of the 123 participants, 105 (85.4%) were retained across at least 1 follow-up period, and there was no difference in follow-up rates between the conditions (χ21=0.6; P=.43). The completion of Teen Well Check took an average of 6.2 (SD 5.8) minutes. Preliminary analyses revealed that there were significant reductions in perceived peer norms (descriptive norms) for substance use before sex across follow-ups among participants in the Teen Well Check condition (P=.001 from baseline to 6 months), whereas there were significant increases among participants in the control condition (P=.003 from baseline to 6 months). In addition, there were nonsignificant reductions in substance misuse risk from baseline to the 6-month follow-up among participants in the Teen Well Check condition (P=.16).

Conclusions
These findings support the feasibility of Teen Well Check delivery within pediatric primary care clinics. A randomized clinical trial is needed to assess efficacy.

Trial Registration
ClinicalTrials.gov NCT3489434; https://www.clinicaltrials.gov/study/NCT03489434
Governance, Investors Motivations and Foreign Direct Investment Inflow in Selected African Countries: Does John Dunning’s Eclectic Paradigm Matters?
Authors: Aberu Felix 
Published: November 2023

Abstract
Over the years, studies have focused on the implications of institutional quality as a key factor of FDI inflows into Africa and how it influences the economic processes of various African countries. However, in the studies on Africa, investors’ motivations as determinants of foreign direct investment inflows into African regions are grossly understudied and yet determined. As a result, there is a need to investigate the impact of FDI inflows on African countries, as well as the implications of home and host country investment phenomena. The study employs ex-post-facto research using panel data obtained from different World Bank publications; world development indicators, and the Transparency Index database from 1997 to 2022. The System Generalized Method of Moments (SGMM) was used to examine the data. The results reveal that governance and investor motivations have a negative impact on each other; the effect of the interacted variables is less than the total of the impacts of governance and investor motivations separately. Therefore, FDI in the selecte3d African countries will decline by 7.5 points for every unit increase in the level of poor governance and investor motivations, and this validates the locational assumption of John Dunning Eclectic Paradigm with the proposition that FDI inflows is a function of the home and host investment phenomena As a result, we recommend that African governments implement Regulatory reform, market reform, complete streets policies, and contingency-based planning that are FDI inflow induced.
Forensic Science Integration in Legal Education: A Paradigm Shift for Strengthening Legal Expertise in Pakistan
Authors: Ali Muhammad Imran 
Published: November 2023

Abstract
The objective and scientific interpretation of evidence provided by forensic science is a crucial component of the contemporary judicial system. In Pakistan, forensic science education is not a part of the required curriculum for obtaining a Bachelor of Law (LL.B.) degree. Lawyer’s knowledge of the scope and limits of forensic research is hindered by the absence of a thorough forensic science component within law school. This, in turn, may obstruct the proper use of forensics in court procedures, which can slow down the distribution of justice. Forensic science education offers numerous benefits, including a holistic understanding of law and forensic science, interdisciplinary skills development, enhanced collaboration between lawyers and experts, and the development of specialized lawyers for handling complex cases. Law students may benefit from a deeper grasp of the scientific processes involved in criminal investigation, evidence collecting, preservation, analysis, and presentation by taking forensic science courses. Future lawyers will benefit from this understanding while trying cases, challenging expert testimony, and arguing on behalf of their clients. This article addresses the advantages, problems, and possible tactics for integrating forensic science into the LL.B. curriculum in Pakistan.