bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut dysbiosis and the role of probiotics in chronic kidney disease
Authors: Cahyadi Alius , Yuwono Angelina , Subagio Stephanie Widodo , Iryaningrum Maria Riastuti 
Published: January 2024

Chronic inflammatory condition in chronic kidney disease (CKD) patients is associated with increased risk of cardiovascular morbidity and mortality. Gut dysbiosis is assumed as one of leading factors to the chronic inflammatory condition. The relationship between the kidney and the gastrointestinal, knowns as the gut-kidney axis, has a role in production and accumulation of uremic toxins derived from gut microbial fermentation of protein, and translocation of endotoxins and microbial from gut lumen into bloodstream due to alterations of intestinal epithelial barrier in CKD patients. Probiotics supplementation is one of the optional theraphy to restore the gut dysbiosis in CKD patients. Recent studies found that probiotics supplementation in CKD patients decreased uremic toxins and pro-inflammatory cytokines production, and delayed CKD progression. The improvement of this chronic inflammatory condition is expected to decrease cardiovascular disease risk in CKD patients. This review aims to describe the importance of gut-kidney axis in CKD patients, particularly in gut dysbiosis, and the role of probiotics in progression of CKD.
Moringa oleifera Lam. to accelerate wound healing: a review
Authors: Jaya Fidi Bhawana , Syamsunarno Mas Rizky Anggun Adipurna , Sahiratmadja Edhyana 
Published: January 2024

An injury to the skin that disrupts the soft tissue may form a wound. The healing process in response to injury is a dynamic and well-regulated process of cellular, humoral, and molecular mechanisms that consists of four partly overlapping phases: hemostasis, inflammation, proliferation, and remodeling. An impaired wound-healing process may cause a formation of an abnormal scar and chronic wounds, leading to a reduced life quality. Therefore, it needs an optimal prevention strategy. Many modalities have been claimed to accelerate wound healing. The trend of using natural products is increasing in most Southeast Asian countries due to their biodiversity. Nowadays, studies on natural compounds are increasing to accelerate wound healing. Moringa oleifera Lam. is a high-value plant that each part of it has a high nutritional value as well as a great range of medicinal uses, including anti-inflammatory, antimicrobial, antioxidant, and wound healing properties. In this review, we have explored the M. oleifera that are very rich in vitamins, minerals, fatty acids, and phytochemical compounds like quercetin, kaempferol, and vicenin-2, that play a role in the wound healing process. Moreover, these compounds may enhance the healing of wounds with pathological conditions such as diabetes, immunocompromised and persistent infection.
Galvanic Corrosion of E690 Offshore Platform Steel in a Simulated Marine Thermocline
Authors: Hu Jiezhen , Lin Guodong , Deng Peichang , Li Ziyun , Tian Yuwan 
Published: January 2024

Marked changes in temperature, pH, dissolved oxygen (DO) content, and nutrient content typically occur in marine thermoclines, which are key factors that affect the corrosion of metals. Offshore platforms have required marine metals to be exposed to deep-sea environments and have thus increased their penetration into the marine thermocline. This study investigates the galvanic corrosion of E690 steel in a marine thermocline using a simulated marine thermocline (SMT). Specifically, the corrosion of E690 steel was analyzed using the wire beam electrode (WBE) technique, linear polarization (LP), corrosion morphology, and weight loss measurement. Results indicated that the SMT had a stable multilayer structure, and the variations of temperature, DO, pH and nutrient concentration in the SMT were similar to those in the natural marine thermocline. Galvanic corrosion occurred after the intrusion of E690 steel into the marine thermocline. The driver of galvanic corrosion was the of E690 steel at various depths of the marine thermocline. The Ecorr of E690 steel was influenced by the temperature, pH and DO of seawater, and the order was DO &gt;&gt; T &gt; pH. The continuous reduction of Ecorr with depth contributed to the large-scale galvanic corrosion, and the oscillation variation of Ecorr with depth was the reason for small-scale galvanic corrosion. The primary anodic regions of galvanic corrosion were located in the area with the fastest temperature variation in the thermocline. The proportion of galvanic corrosion in the average corrosion rate could increase up to approximately 80% in the stable anodic region. There were many deep corrosion pits in the long-term and stable anodic region of galvanic corrosion.
Nietzsche’nin Perspektivizmi ve Heidegger’in “Dünya” Kavramı: Kurosava’nın Raşomon’u Üzerinden Bir Birlikte Okuma
Authors: YILDIZ Necdet 
Published: January 2024

Bu yazıda Nietzsche’nin özellilke Türkçe literatürde sıklıkla ihmal edilen “perspektivizm”
düşüncesini Heidegger’in felsefesinde son derece önemli bir yer tutan “dünya” kavramı ile birlikte
Akira Kurosava’nın Raşomon adlı sinema filmi üzerinden okuyacağız. Böylelikle, hem Nietzsche
felsefesinin bugün bile geçerliliğini koruduğu söylenebilecek özünü —yani, perspektivizm
düşüncesini— açıklayıp yorumlayacağız; hem Heidegger’in “dünya” kavramının Nietzsche’nin
perspektivizmi üzerinden nasıl okunabileceğini gösterecek ve onu Nietzsche’nin perspektivist
diliyle yeniden anlatacağız; hem de Akira Kurosawa’nın Raşomon adlı filminde bu felsefi temaların
nasıl görünür kılınıp yeni sorularla derinleştirerek bir “video-felsefe” yaptığını ortaya koyacağız. Bu
amaçlar doğrultusunda, ilk bölümde Nietzsche’nin perspektivizm düşüncesinin ne olduğunu anlatıp
onu “ne olsa gider” türündeki rölativist anlayışlardan ayıracağız. İkinci bölümde Heidegger’in
“dünya” kavramını nasıl incelediğini ve “dünya-içinde-varlık” fikrinin neden Nietzsche’deki
perspektivizm düşüncesine paralel bir anlayış olduğunu ortaya koyacağız. Son olarak, bu iki
düşünceye dair örnekleri Raşomon filminde sergilenen “tanıklık fenomenolojisi” ve bu
fenomenolojinin akla getirdiği bazı felsefi pozisyonlar üzerinden birlikte okuyup, filmin bu felsefi
tartışmayı nerelere doğru yönelttiğini soruşturacağız.
Transiciones de poder en la región de las tierras intermedias de Elden Ring
Authors: Guadarrama Sánchez Hugo Alberto 
Published: January 2024

Los videojuegos como contenidos interactivos además de ser productos digitales para entretener a los entusiastas, presentan una historia que proporciona un contexto con el cual los videojugadores pueden conectar, dependiendo del grado de interpretación de cada persona cada videojuego puede tener diferentes perspectivas de análisis. El presente texto tiene como objetivo identificar los intereses ideológicos de las principales facciones dominantes que provocaron un desequilibrio en la ruptura del orden, en el videojuego de Elden Ring. Teniendo como marco teórico algunos elementos acerca del Estado y el poder, con el propósito de interpretar desde una postura académica las diferentes narrativas publicadas en la plataforma de YouTube, así como otros sitios web especializados en la historia de Elden Ring. Lo cual conlleva a considerar que, el entramado de las relaciones sociales entre los distintos personajes principales como agentes de cambio se debe a las conexiones que se generan a raíz de los intereses en común.
Developing interactive pedagogies: A case of accounting pre-service teachers from Ghana
Authors: Fentim Darkwa Bernard , Darko Agyei Douglas , Tufuor Kwarteng Joseph 
Published: January 2024

This is a study of how eight pre-service teachers developed their skills in developing interactive lessons to teach concepts in Accounting in Senior High Schools in Ghana. Sequential multiple case study design was employed to observe two cohorts of four pre-service teachers who worked in two phases of a professional development scenario to design and enact interactive Accounting lessons. Data for the study were collected through observation, interviews, lesson documents and questionnaires. Pictures, content and thematic analysis procedures were used to analyse the qualitative data, whilst means and standard deviation were used to analyse the quantitative data. It emerged from the results that the interactive lessons developed and implemented by the pre-service teachers were effective in promoting participation in the classroom. The study also brought to light that interactive teaching promotes collaboration among students through solving problems in groups which helps to strengthen the bond between students. The study thus, advocates the need for teacher training institutions to focus on training teachers to acquire the skills in designing and enacting lessons interactively to promote students’ participation in the classroom.
Glutathione overproduction mediates lymphoma initiating cells survival and has a sex-dependent effect on lymphomagenesis
Authors: Campanero Miguel R. , H-Alcántara Alberto , Kourani Omar , Martínez-Núñez Patricia , Herranz-Martín Estela , Fuentes Patricia , Toribio Maria L. , Marcos-Jiménez Ana , Muñoz-Calleja Cecilia , Iglesias Teresa 
Published: January 2024

Abstract

Lymphoid tumor patients often exhibit resistance to standard therapies or experience relapse post-remission. Relapse is driven by Tumor Initiating Cells (TICs), a subset of tumor cells capable of regrowing the tumor and highly resistant to therapy. Growing cells in 3D gels is a method to discern tumorigenic cells because it strongly correlates with tumorigenicity. The finding that TICs, rather than differentiated tumor cells, grow in 3D gels offers a unique opportunity to unveil TIC-specific signaling pathways and therapeutic targets common to various cancer types. Here, we show that culturing lymphoid cells in 3D gels triggers reactive oxygen species (ROS) production, leading to non-tumor lymphoid cell death while enabling the survival and proliferation of a subset of lymphoma/leukemia cells, TICs or TIC-like cells. Treatment with the antioxidant N-acetylcysteine inhibits this lethality and promotes the growth of primary non-tumor lymphoid cells in 3D gels. Some lymphoma cells escape ROS-induced lethality by boosting antioxidant glutathione production, a response not seen in non-tumor cells. Reducing glutathione production in lymphoma cells, either through pharmacological inhibition of glutamate cysteine ligase (GCL), the enzyme catalyzing the rate-limiting step in glutathione biosynthesis, or via knockdown of GCLC, the GCL catalytic subunit, sharply decreased cell growth in 3D gels and xenografts. Tumor cells from B-cell lymphoma/leukemia patients and l-MYC mice, a B-cell lymphoma mouse model, overproduce glutathione. Importantly, pharmacological GCL inhibition hindered lymphoma growth in female l-MYC mice, suggesting that this treatment holds promise as a therapeutic strategy for female lymphoma/leukemia patients.
Identifying and modulating neural signatures of stress susceptibility and resilience enables control of anhedonia
Authors: Kheirbek Mazen , Xia Frances , Fascianelli Valeria , Vishwakarma Nina , Ghinger Frances , Fusi Stefano 
Published: January 2024

Abstract

Anhedonia is a core aspect of major depressive disorder. Traditionally viewed as a blunted emotional state in which individuals are unable to experience joy, anhedonia also diminishes the drive to seek rewards and the ability to value and learn about them 1–4.The neural underpinnings of anhedonia and how this emotional state drives related behavioral changes remain unclear. Here, we investigated these questions by taking advantage of the fact that when mice are exposed to traumatic social stress, susceptible animals become socially withdrawn and anhedonic, where they cease to seek high-value rewards, while others remain resilient. By performing high density electrophysiological recordings and comparing neural activity patterns of these groups in the basolateral amygdala (BLA) and ventral CA1 (vCA1) of awake behaving animals, we identified neural signatures of susceptibility and resilience to anhedonia. When animals actively sought rewards, BLA activity in resilient mice showed stronger discrimination between upcoming reward choices. In contrast, susceptible mice displayed a rumination-like signature, where BLA neurons encoded the intention to switch or stay on a previously chosen reward. When animals were at rest, the spontaneous BLA activity of susceptible mice was higher dimensional than in controls, reflecting a greater number of distinct neural population states. Notably, this spontaneous activity allowed us to decode group identity and to infer if a mouse had a history of stress better than behavioral outcomes alone. Finally, targeted manipulation of vCA1 inputs to the BLA in susceptible mice rescued dysfunctional neural dynamics, amplified dynamics associated with resilience, and reversed their anhedonic behavior. This work reveals population-level neural signatures that explain individual differences in responses to traumatic stress and suggests that modulating vCA1-BLA inputs can enhance resilience by regulating these dynamics.
Assessing the Relationship of Personality Traits to Specialty Choice in the Interest of Mental Health and Resilience
Authors: Zamora Diana C , Guerrero Gloria Sofía , Vélez-Vallejo Daniela , López-Patrón Miguel Rafael , Buitrago Maria Camila , Cano Juan F 
Published: January 2024

Abstract

Objective Analyze the relationship between the personality traits prevalent in final-year medical students and graduate medical-surgical residency students at Universidad del Rosario with their area of interest for a possible medical-surgical residency choice.Methods A cross-sectional observational analytical study was carried out with two reference groups: final-year medical students, with 102 participants (44.2%), and a second group with residents in medical specialties at Universidad del Rosario, with 129 subjects (55.8%), for a sample size of 231 individuals surveyed using the modified Big Five Inventory. This inventory is a 30-item personality test that identifies five essential dimensions for describing and evaluating personality (extraversion, agreeableness, conscientiousness, neuroticism, and degree of “mental openness”).Results A homogenous distribution tendency was found among final-year students regarding personality traits when comparing the choice between a medical or surgical residency; statistically significant differences were only found in extraversion (p = 0.0168) and conscientiousness (p = 0.0137). The latter translates into a difference of +/- 2–3 points (18.8 to 21.3 and 19.3 to 21.3, respectively) between the groups in the last dimensions mentioned. Additionally, there was homogeneity found in the distribution of both groups of residents in which no statistically significant differences were found in any of the dimensions when comparing surgical and medical residents.Conclusions The study suggests that strengthening appropriate personality traits in medical students is essential as these decisions positively impact the mental health and resilience of the individuals and the nation’s workforce.
Suppressing argyrodite oxidation by tuning the host structure for high areal capacity all-solid-state lithium-sulfur batteries
Authors: Nazar Linda , Yu Zhuo , Yu Yue , Singh Baltej 
Published: January 2024

Abstract
Sulfide-based solid catholytes such as argyrodite (Li6PS5Cl) are promising materials for high-performance solid-state sulfur cells that operate on the reversible conversion of S ↔ Li2S. However, the electrochemical decomposition of argyrodite above 2.5 V vs Li+/Li causes its progressive degradation in the operating window of the cell, because the free S2- ions in Li6PS5Cl are oxidized to sulfur at a similar potential as Li2S. Here we demonstrate that – in addition to regulating the local electronic contact - creating a strong interaction between the Li-ions in argyrodite and the sulfur host synergistically suppresses oxidation of the argyrodite by inhibiting the first step in the pathway. A carbon nitride/N-doped graphene host serves as proof-of-concept to demonstrate this effect. Additionally, its moderate electron transport easily supports operation of all-solid-state lithium-sulfur batteries but constrains electron mobility at the interface with argyrodite. As a consequence, all-solid-state lithium-sulfur batteries utilizing this host material deliver superior rate capability and stable long-term cycling compared to non-polar conductive carbon materials. An areal capacity of 2 mAh cm-2 was achieved over 230 cycles at room temperature, while a high capacity of 11.3 mAh cm-2 was obtained with 90% retention at elevated temperature (60 °C). The newly presented descriptors in this work enrich the understanding of solid electrolyte redox activities and guide the interface and material design in all-solid-state lithium-sulfur batteries.
Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells.
Authors: Apte Bela Anand , Grenell Allison , Singh Charandeep , Raju Monisha , Wolk Alysson , Dalvi Sonal , Jang Geeng-Fu , Crabb Jack , Hershberger Courtney , Manian Kannan , Crabb John , Singh Ruchira , Du Jianhai 
Published: January 2024

Abstract
Mutations in Tissue Inhibitor of Metalloproteinases 3 (TIMP3) cause Sorsby’s Fundus Dystrophy (SFD), a dominantly inherited, rare form of macular degeneration that results in vision loss. TIMP3 is synthesized primarily by retinal pigment epithelial (RPE) cells, which constitute the outer blood-retinal barrier. Quantitative proteomics and RNAseq analysis on the choroid/RPE of mice expressing mutant TIMP3 identified a dysregulation in metabolic processes. We examined the effects of mutant TIMP3 on RPE metabolism using human ARPE-19 cells expressing mutant S179C TIMP3 and patient-derived induced pluripotent stem cell-derived RPE (iRPE) carrying the S204C TIMP3 mutation. Stable isotope tracing experiments demonstrated enhanced glucose utilization and glycolytic activity in mutant RPE concomitantly with altered glutamine utilization. This study provides important information on the dysregulation of the metabolome of RPE cells in SFD and implicates a potential commonality with other retinal degenerative diseases, emphasizing RPE cellular metabolism as a therapeutic target.
Identification of Related-Genes of T cells in Lung Tissue of Chronic Obstructive Pulmonary Disease Based on Bioinformatics and Experimental Validation
Authors: Xue Ting , Dong Fei , Gao Jinglin , Zhong Xiaoning 
Published: January 2024

Abstract
T cells are one of the main cell types shaping the immune microenvironment in chronic obstructive pulmonary disease(COPD).They persist and play cytotoxic roles.The purpose of this study aimed to explore the potential related-genes of T cells in lung tissue of COPD.Chip data GSE38974 and single_cell data GSE196638 were downloaded from the GEO database.Difference analyses and WGCNA of GSE38974 were performed to identify DEGs and the modules most associated with the COPD phenotype.Various cell subsets were obtained by GSE196638, and DEGs of T cells were further identified.GO,GSEA and KEGG enrichment analyses were conducted to explore the biological functions and regulatory signaling pathways of the DEGs and DEGs of T cells.The intersection of the DEGs,module genes and DEGs of T-cells was assessed to acquire related-genes of T cells.The mRNA and protein expression levels of related-genes of T cells were verified in lung tissue of mouse with emphysema model.Based on GSE38974 difference analysis,3811 DEGs were obtained.The results of WGCNA showed that the red module had the highest correlation coefficient with the COPD phenotype.GSE196638 analysis identified 124 DEGs of T cells.The GO,GSEA and KEGG enrichment analyses mainly identified genes involved in I-kappaB kinase/NF-kappaB signaling,receptor signaling pathway via STAT,regulation of CD4-positive cells,regulation of T-helper cell differentiation,chemokine signaling pathway,Toll-like receptor signaling pathway,CD8-positive cells,alpha-beta T cell differentiation,MAPK signaling pathway and Th17 cell differentiation.The DEGs,genes of the red module and DEGs of T cells were overlapped to acquire FOXO1 and DDX17.The results of RT-qPCR and Western Blot indicate that the mRNA and protein expression levels of FOXO1 and DDX17 in lung tissue of emphysema mice were significantly higher compared with those in air-exposed mice.FOXO1 as well as DDX17 may be related-genes of T cells in lung tissue of patient with COPD,and their participation in the biological processes of different signaling pathways may inspire further COPD research.
Enzymatization of mouse monoclonal antibody to the corresponding catalytic antibody
Authors: Hifumi Emi , Ito Yuina , Tsujita Moe , Taguchi Hiroaki , Uda Taizo 
Published: January 2024

Abstract
Catalytic antibodies exhibit unique features for recognizing and degrading antigens. However, the production of these antibodies is time-consuming and labor-intensive. Herein, mouse monoclonal antibodies (mAbs) were converted into catalytic antibodies by deleting Pro95 in the light chain using three antibodies targeting the influenza A virus. Although no catalytic activity was observed for the mAbs and light chains, Pro95-deleted light chains exhibited catalytic activity for cleaving the antigenic peptide. The affinity of the Pro95-deleted light chains for the antigen increased approximately 100-fold compared to that of the wild-type light chains. Notably, the Pro95-deleted mutants suppressed influenza virus infection in the in vitro assay. Molecular modeling suggested that three residues (Asp1, Ser92, and His93) in the mutant moved closer to the appropriate position, enhancing catalytic function and immunoreactivity. Note that a rapid and simple method for generating catalytic antibodies for various diagnostic and therapeutic applications from exiting antibodies were attained.
Prevalence and risk factors of overweight and obesity among children and adolescents in Hangzhou: a cross sectional study
Authors: Zhao Lijuan , Jiang Xiujun , Zhang Wenhui , Hao Li , Zhang Yuting , Wu Shangxi , Zhu Bing 
Published: January 2024

Abstract

Purpose To investigate the prevalence and influencing factors of overweight and obesity among primary and secondary school students in Hangzhou city, and provide ideas for the formulation of overweight and obesity prevention and control measures.Methods A total of 353,783 primary and middle school students in 13 districts of Hangzhou city were investigated with physical examination. Using a stratified cluster random sampling method, 6,148 students of primary and junior high school from 24 schools were investigated via questionnaires. Univariate and multivariate logistic regression were used to screen possible risk factors of overweight and obesity.Results The overall overweight and obesity rate was 27.20%, with the increase of the school period, the prevalence of overweight and obesity among students showing downtrend (χ2 = 14.47, P<0.01). The prevalence of overweight and obesity in girls is lower than that in boys (χ2 = 69.79, P<0.01); the prevalence of overweight and obesity in urban students is higher than that in suburban students (χ2 = 2.01, P = 0.02). High blood pressure, had menstruation or nocturnal emission, eating fresh fruit ≥ 1 time a day, daily brushing ≥ 2 times and bullying victimization are independently associated with higher prevalence of overweight and obesity. Moreover, the increased school period, girls and boarding student are protective factors for overweight and obesity.Conclusions The overweight and obesity prevalence among children and adolescents in Hangzhou is still at a relatively high level, and is affected by most factors such as high blood pressure, had menstruation or nocturnal emission, eating fresh fruit frequency, school period and gender, needing targeted intervention measures.