bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of probiotic and prebiotic supplementation on intestinal microbiota and resistance to Edwardsiella ictaluri infection in channel catfish (Ictalurus punctatus) following florfenicol administration
Authors: Older Caitlin E. , Griffin Matt J. , Richardson Bradley M. , Waldbieser Geoffrey C. , Reifers J. Grant , Goodman Penelope M. , Ware Cynthia , Gatlin Delbert M. , Wise David J. , Yamamoto Fernando Y. 
Published: December 2023

AbstractEnteric septicemia of catfish (ESC), caused by the gram‐negative enteric bacteria Edwardsiella ictaluri, is a significant threat to catfish aquaculture in the southeastern United States. Antibiotic intervention can reduce mortality; however, antibiotic use results in an imbalance, or dysbiosis, of the gut microbiota, which may increase susceptibility of otherwise healthy fish to enteric infections. Herein, recovery of the intestinal microbiota and survivability of channel catfish in response to ESC challenge was evaluated following a 10‐day course of florfenicol and subsequent probiotic or prebiotic supplementation. Following completion of florfenicol therapy, fish were transitioned to a basal diet or diets supplemented with a probiotic or prebiotic for the remainder of the study. Digesta was collected on Days 0, 4, 8 and 12, beginning on the first day after cessation of antibiotic treatment, and gut microbiota was characterized by Illumina sequencing of the 16S rRNA gene (V4 region). Remaining fish were challenged with E. ictaluri and monitored for 32 days post‐challenge. Florfenicol administration resulted in dysbiosis characterized by inflated microbial diversity, which began to recover in terms of diversity and composition 4 days after cessation of florfenicol administration. Fish fed the probiotic diet had higher survival in response to ESC challenge than the prebiotic (p = .019) and negative control (p = .029) groups.
Oncologic, fertility, and obstetric outcomes with MPA therapy in women with endometrial cancer and atypical endometrial hyperplasia
Authors: Takeda Asuka , Yamamoto Yuri , Tamura Kou , Aoki Hidenori , Noguchi Hiroki , Minato Saki , Kamada Shuhei , Arakaki Ryosuke , Kaji Takashi , Iwasa Takeshi 
Published: December 2023

AbstractAimMedroxyprogesterone acetate (MPA) is one of the treatments of atypical endometrial hyperplasia (AEH) and endometrial cancer (EC) to preserve the fertility. Efficacy of MPA therapy and fertility and obstetric outcomes after remission were evaluated in EC or AEH patients.MethodsAmong patients diagnosed with EC or AEH at Tokushima University Hospital between January 2002 and October 2020, we retrospectively analyzed patients, ages range from 26 to 40, who underwent conservative management using MPA (400–600 mg/day).ResultsIn total, 19 patients underwent MPA therapy. The 18 (94%) patients achieved complete response (CR), and 1 (5%) patient achieved partial response (PR). Relapse occurred in 6 (32%) patients who had achieved CR. Of the patients who relapsed, 4 patients resumed MPA therapy and were in remission. Among 19 patients, 13 patients attempted pregnancy after CR. All of them underwent ovulation induction or assisted reproductive technology. As a result, 20 pregnancies in 10 (77%) patients and 12 live births in 9 (69%) patients were achieved. Rate of spontaneous abortion was 35% (7/20).ConclusionsMPA therapy can produce a high remission rate, and be considered an effective treatment for patients who wish fertility preservation. Around 70% patients who attempt to pregnancy can have at least one baby by infertility treatments. Because recurrence rate after MPA therapy is high, it may be desirable to aim for early pregnancy by active intervention.
Masticatory performance, self‐perception of oral health, oral health‐related quality of life and nutritional status of completely edentulous elderly patients submitted to different rehabilitation treatments: A cross‐sectional study
Authors: Jabr Camila Luiz , Oliveira Lucas Portela , Pero Ana Carolina , de Assis Mollo Júnior Francisco , Filho João Neudenir Arioli 
Published: December 2023

AbstractBackgroundThe impact of treatments on completely edentulous individuals on masticatory performance (MP), oral health‐related quality of life (OHRQoL), nutritional status (NS) and socio‐economic profile (SP) is unclear in the literature.ObjectiveTo compare the MP, OHRQoL, NS and SP of totally edentulous elderly users of bimaxillary complete dentures (CD) and users of lower implant‐supported fixed complete dentures (IFCD).MethodsForty participants were allocated into groups according to rehabilitation treatment (n = 20): bimaxillary CD (G1) and lower IFCD, and upper CD (G2). The evaluation of MP used almonds by the method of sieves. Four questionnaires (Geriatric Oral Health Assessment Index–GOHAI and Oral Health Impact Profile Edent–OHIP‐Edent, Brazilian Economic Classification Criteria–ABEP and Mini Nutritional Assessment‐MNA) were applied to assess the OHRQoL, SP and NS of the elderly, respectively. After evaluating the statistical assumptions, the Mann–Whitney (α = .05) test was applied to compare the groups regarding MP, OHRQoL, NS and SP. Spearman's correlation (α = .05) was performed to verify the correlation between the MP, the OHRQoL and the NS of the participants.ResultsG2 showed better MP (p < .05) in all masticatory cycles, OHRQoL (p < .05) and NS than the G1. However, the participants' self‐perception of oral health did not differ between groups (p < .05). A moderate negative correlation was found between MP and OHRQoL for 40 masticatory cycles (r2 = −0.513; p = .001).ConclusionIndividuals rehabilitated with IFCD had a higher average monthly family income and achieved superior behaviour in MP and OHRQoL, in addition to lower risks of malnutrition when compared to individuals using bimaxillary CD.
Upper turnaround point in a reentry circuit of the idiopathic left posterior fascicular ventricular tachycardia
Authors: Hwang Jongmin , Nam Gi‐Byoung , Kim June Hong , Kim Jun , Choi Kee‐Joon , Kim You‐Ho 
Published: December 2023

AbstractBackgroundThe anatomic extent of the reentry circuit in idiopathic left posterior fascicular ventricular tachycardia (LPF‐VT) is yet to be fully elucidated. We hypothesized that entrainment mapping could be used to delineate the reentry circuit of an LPF‐VT, especially including the upper turnaround point.MethodsTwenty‐three consecutive LPF‐VT patients (mean age, 29 ± 9 years, 18 males) were included. We performed overdrive pacing with entrainment attempts at the left bundle branch (LBB) and the left His bundle (HB) region.ResultsOverdrive pacing from the LBB region showed concealed fusion in all 23 patients (post‐pacing interval [PPI], 322.1 ± 64.3 ms; tachycardia cycle length [TCL], 319.0 ± 61.6 ms; PPI‐TCL, 3.1 ± 4.6 ms) with a long stimulus‐to‐QRS interval (287.9 ± 58.0 ms, approximately 90% of the TCL). Pacing from the same LBB region at a slightly faster pacing rate showed manifest fusion with antidromic conduction to the LBB and minimal in‐and‐out time to the LBB potential (PPI‐TCL, 21.3 ± 13.7 ms). Overdrive pacing from the left HB region showed manifest fusion with a long PPI‐TCL (53.9 ± 22.5 ms).ConclusionsOur pacing study results suggest that the upper turnaround point in a reentry circuit of the LPF‐VT may extend to the proximal His‐Purkinje conduction system near the LBB region but below the left HB region. The LPF may constitute the retrograde limb of the reentry circuit.
The Western Australian Mesothelioma Registry: Analysis of 60 years of cases
Authors: Brims Fraser , Kumarasamy Chellan , Menon Lalitha , Olsen Nola , de Klerk Nick , Franklin Peter 
Published: December 2023

AbstractBackground and ObjectiveAustralia introduced a partial ban on asbestos consumption in 1984. There is continuing concern about exposure to asbestos in the built environment and non‐occupational exposures. The aim of this study was to describe epidemiological trends of mesothelioma in Western Australia (WA) over the 60 years since the first case was recorded.MethodsEvery case of mesothelioma notified to the WA Cancer Registry is reviewed by an expert panel. Data include demographic and clinical variables including principal mode of asbestos exposure and age at first exposure. Trends over time for survival, latency and pathological subtype of mesothelioma where analysed. Incidence rates for cases exposed during home renovation where calculated.ResultsTwo thousand seven hundred ninety‐six cases of mesothelioma were identified with males comprising the majority (n = 2368, 84.7%). The median (IQR) age at diagnosis was 70 (62–78) years, and median latency of 47 (38–55) years. Pleural mesothelioma was recorded in 2620 (93.7%) cases with the epithelioid subtype most prevalent (n = 1730, 61.9%). Overall, median survival was 298 (128–585) days and latency 46 (37–54) years, both effectively doubling over the study period. Non‐occupational exposures were proportionally higher in females (52.6%), compared with males (9.5%). Home renovation was the primary exposure in 227 (8.1%) cases, with number of cases and incidence rate ratio peaking in 2005/09 but subsequently decreasing.ConclusionThe annual number of cases of mesothelioma in WA may have hit a plateau. The majority of females have non‐occupational exposures and incidence rates from home renovation exposure may have peaked, suggesting the ban on asbestos has been effective.
Dentofacial manifestations in a child with Jalili syndrome
Authors: Ravi Mugilan , Karthikeyan Pavithra Devi , Tewari Nitesh , Morankar Rahul , Gupta Amit Kumar , Nehta Hemlata , Raghuthaman Sruthila 
Published: December 2023

AbstractJalili syndrome (JS) (MIM#217080) is a rare autosomal recessive disorder with oculo‐dental malformations. The clinical phenotype is characterized by the presence of Cone‐Rod Dystrophy (CRD) and Amelogenesis Imperfecta (AI). Genetic mechanism entails a mutation in the CNNM4, a metal transporter gene located on Chromosome 2q11.2. A high fluoride concentration in groundwater has also been identified as an epigenetic factor in this syndrome. JS draws the attention of dentists due to its distinct oral manifestations. To the best of our knowledge, this is the first genetically confirmed pediatric case report from the Indian subcontinent emphasizing the clinical and radiographic features of this condition and its management in a 6‐year‐old child.
Equivariant resolutions over Veronese rings
Authors: Almousa Ayah , Perlman Michael , Pevzner Alexandra , Reiner Victor , VandeBogert Keller 
Published: December 2023

AbstractWorking in a polynomial ring , where is an arbitrary commutative ring with 1, we consider the th Veronese subalgebras , as well as natural ‐submodules inside . We develop and use characteristic‐free theory of Schur functors associated to ribbon skew diagrams as a tool to construct simple ‐equivariant minimal free ‐resolutions for the quotient ring and for these modules . These also lead to elegant descriptions of for all and for any pair of these modules .
Life Cycle Assessment of Selected Ammonia Production Technologies From the Perspective of Ammonia as a Fuel for Heavy-Duty Vehicle
Authors: Proniewicz Mateusz , Petela Karolina , Szlęk Andrzej , Adamczyk Wojciech 
Published: December 2023

Abstract
One of the promising options for the decarbonization of industry dependent on heavy-duty vehicles is to use alternative fuels such as ammonia. The study investigates the environmental impact of five selected ammonia production technologies and compares them to diesel fuel: ammonia based on hydrogen from steam methane reforming (gray), ammonia based on steam methane reforming with carbon capture and storage (blue), ammonia based on hydrogen from electrolysis with electrical energy supplied by: PV (green PV), wind (green wind), and nuclear plant (pink). Environmental impact is assessed using the ReCiPE method based on three midpoint and two endpoint categories: climate change, fossil depletion, freshwater consumption, human health, and ecosystem quality. The climate change results per 1 MJ (LHV) are as follows: gray ammonia at 0.148 kg CO2 eq., blue ammonia at 0.0701 kg CO2 eq., green ammonia PV at 0.0197 kg CO2 eq., green ammonia wind at 0.01039 kg CO2 eq., pink ammonia at 0.00565 kg CO2 eq., and diesel (including its stoichiometric combustion) at 0.0851 kg CO2 eq. The life cycle assessment (LCA) was performed using the lca for experts (GaBi) software, with Sphera's comprehensive Managed LCA Content as the primary data source for the life cycle inventory. The study indicates nuclear and renewable-based routes to be the best options in terms of the climate change and human health categories; however, their high impact on freshwater consumption and ecosystem quality is revealed. Still, ammonia is proven to be an effective solution toward decarbonization, as compared to diesel, given its blue, green, or pink source.
Healthcare resource utilisation and costs of hospitalisation and primary care among adults with COVID-19 in England: a population-based cohort study
Authors: Yang Jingyan , Andersen Kathleen Michelle , Rai Kiran K , Tritton Theo , Mugwagwa Tendai , Reimbaeva Maya , Tsang Carmen , McGrath Leah J , Payne Poppy , Backhouse Bethany Emma , Mendes Diana , Butfield Rebecca , Naicker Kevin , Araghi Mary , Wood Robert , Nguyen Jennifer L 
Published: December 2023

ObjectivesTo quantify direct costs and healthcare resource utilisation (HCRU) associated with acute COVID-19 in adults in England.DesignPopulation-based retrospective cohort study using Clinical Practice Research Datalink Aurum primary care electronic medical records linked to Hospital Episode Statistics secondary care administrative data.SettingPatients registered to primary care practices in England.Population1 706 368 adults with a positive SARS-CoV-2 PCR or antigen test from August 2020 to January 2022 were included; 13 105 within the hospitalised cohort indexed between August 2020 and March 2021, and 1 693 263 within the primary care cohort indexed between August 2020 and January 2022. Patients with a COVID-19-related hospitalisation within 84 days of a positive test were included in the hospitalised cohort.Main outcome measuresPrimary and secondary care HCRU and associated costs ≤4 weeks following positive COVID-19 test, stratified by age group, risk of severe COVID-19 and immunocompromised status.ResultsAmong the hospitalised cohort, average length of stay, including critical care stays, was longer in older adults. Median healthcare cost per hospitalisation was higher in those aged 75–84 (£8942) and ≥85 years (£8835) than in those aged <50 years (£7703). While few (6.0%) patients in critical care required mechanical ventilation, its use was higher in older adults (50–74 years: 8.3%; <50 years: 4.3%). HCRU and associated costs were often greater in those at higher risk of severe COVID-19 than in the overall cohort, although minimal differences in HCRU were found across the three different high-risk definitions. Among the primary care cohort, general practitioner or nurse consultations were more frequent among older adults and the immunocompromised.ConclusionsCOVID-19-related hospitalisations in older adults, particularly critical care stays, were the primary drivers of high COVID-19 resource use in England. These findings may inform health policy decisions and resource allocation in the prevention and management of COVID-19.
Short birth interval prevalence, determinants and effects on maternal and child health outcomes in Asia-Pacific region: a systematic review and meta-analysis protocol
Authors: Shifti Desalegn Markos , Chojenta Catherine , Hassen Tahir Ahmed , Harris Melissa L 
Published: December 2023

BackgroundShort birth interval (SBI) has been linked to an increased risk of adverse maternal, perinatal, infant and child health outcomes. However, the prevalence and maternal and child health impacts of SBI in the Asia-Pacific region have not been well understood. This study aims to identify and summarise the existing evidence on SBI including its definition, measurement prevalence, determinants and association with adverse maternal and child health outcomes in the Asia-Pacific region.MethodsFive databases (MEDLINE, Scopus, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Maternity and Infant Care, and Web of Science (WoS)) will be systematically searched from September 2000 up to May 2023. Data will be extracted, charted, synthesised and summarised based on the outcomes measured, and where appropriate, meta-analysis will be performed. The risk of bias will be assessed using Joanna Briggs Institute quality appraisal. Grading of Recommendation Assessment, Development and Evaluation framework will be used to evaluate the quality of cumulative evidence from the included studies.Ethics and disseminationThis review does not require ethics approval. Findings will be disseminated through peer-reviewed publications, policy briefs and conference presentations.PROSPERO registration numberA protocol will be registered on PROSPERO for each separate outcome before performing the review.Cite Now
Quantifying Parkinson’s disease severity using mobile wearable devices and machine learning: the ParkApp pilot study protocol
Authors: Ymeri Gent , Salvi Dario , Olsson Carl Magnus , Wassenburg Myrthe Vivianne , Tsanas Athanasios , Svenningsson Per 
Published: December 2023

IntroductionThe clinical assessment of Parkinson’s disease (PD) symptoms can present reliability issues and, with visits typically spaced apart 6 months, can hardly capture their frequent variability. Smartphones and smartwatches along with signal processing and machine learning can facilitate frequent, remote, reliable and objective assessments of PD from patients’ homes.AimTo investigate the feasibility, compliance and user experience of passively and actively measuring symptoms from home environments using data from sensors embedded in smartphones and a wrist-wearable device.Methods and analysisIn an ongoing clinical feasibility study, participants with a confirmed PD diagnosis are being recruited. Participants perform activity tests, including Timed Up and Go (TUG), tremor, finger tapping, drawing and vocalisation, once a week for 2 months using the Mobistudy smartphone app in their homes. Concurrently, participants wear the GENEActiv wrist device for 28 days to measure actigraphy continuously. In addition to using sensors, participants complete the Beck’s Depression Inventory, Non-Motor Symptoms Questionnaire (NMSQuest) and Parkinson’s Disease Questionnaire (PDQ-8) questionnaires at baseline, at 1 month and at the end of the study. Sleep disorders are assessed through the Parkinson’s Disease Sleep Scale-2 questionnaire (weekly) and a custom sleep quality daily questionnaire. User experience questionnaires, Technology Acceptance Model and User Version of the Mobile Application Rating Scale, are delivered at 1 month. Clinical assessment (Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS)) is performed at enrollment and the 2-month follow-up visit. During visits, a TUG test is performed using the smartphone and the G-Walk motion sensor as reference device. Signal processing and machine learning techniques will be employed to analyse the data collected from Mobistudy app and the GENEActiv and correlate them with the MDS-UPDRS. Compliance and user aspects will be informing the long-term feasibility.Ethics and disseminationThe study received ethical approval by the Swedish Ethical Review Authority (Etikprövningsmyndigheten), with application number 2022-02885-01. Results will be reported in peer-reviewed journals and conferences. Results will be shared with the study participants.
Endoscopic retrograde cholangiopancreatography utilisation and outcomes in the first advanced endoscopy centre in Palestine at Al-Ahli Hospital: a retrospective cohort study
Authors: Salama HusamEddin Z , Alnajjar Yousef A , Owais Tarek A , Jobran Afnan W M , Safi Ruaa , Bahar Mohammad , Al-Ashhab Hazem 
Published: December 2023

ObjectiveTo evaluate the utilisation and outcomes of endoscopic retrograde cholangiopancreatography (ERCP) procedures, success rates, incidence and risk factors for procedural-related complications in a single centre-based study.Study designRetrospective cohort study.SettingFirst advanced tertiary endoscopy centre in Palestine.ParticipantsA total of 1909 procedures on 1303 patients were included in the analysis: females were 57.9% of the cases (n=755), 1225 patients (94%) were from West Bank and Jerusalem and 78 (6%) were from Gaza Strip. All patients who underwent ERCP throughout the period from December 2017 to September 2022 were selected to participate in the study.Primary and secondary outcome measuresThe primary outcomes of interest in our analysis were success rates, procedural outcomes and post- procedural complications including pancreatitis, bleeding and others. Two multivariate logistic regression models were performed to calculate the risk of post-ERCP complications and post-ERCP pancreatitis (PEP) in patients with certain risk factors like demographic factors, procedural techniques' variation, pancreatic duct manipulations and others. We also discussed the management of the failed procedures.ResultsThe overall complication rate was 5%, including PEP (n=43, 2.3%), infection/cholangitis (n=20, 1%), bleeding (n=9, 0.5%) and perforation (n=7, 0.4%). The mortality rate was 0.6% (n=11). Risk factors for adverse events included pancreatic duct cannulation and PEP (p<0.001, OR=3.64). Additionally, younger patients (≤45) were found to carry a higher risk for PEP when compared with older patients (≥65) (p=0.023, OR=2.84). In comparison with sphincterotomy, the double-wire technique was associated with a higher risk of complications (p=0.033, OR=2.29).ConclusionsWe summarised the utilisation and outcomes of ERCP among the Palestinian population in the first advanced centre in Palestine. Cannulation success rates are similar to the established standards and are acceptable compared with other centres worldwide. Perioperative complication rates of ERCP remain infrequent, and death is quite unusual and thus considered a safe procedure.