bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct roles of amylin and oxytocin signaling in intrafamilial social behaviors at the medial preoptic area of common marmosets
Authors: Kurachi Takuma , Shinozuka Kazutaka , Yoshihara Chihiro , Yano-Nashimoto Saori , Murayama Ayako Y. , Hata Junichi , Haga Yawara , Okano Hideyuki , Kuroda Kumi O. 
Published: December 2023

AbstractCalcitonin receptor (Calcr) and its brain ligand amylin in the medial preoptic area (MPOA) are found to be critically involved in infant care and social contact behaviors in mice. In primates, however, the evidence is limited to an excitotoxic lesion study of the Calcr-expressing MPOA subregion (cMPOA) in a family-living primate species, the common marmoset. The present study utilized pharmacological manipulations of the cMPOA and shows that reversible inactivation of the cMPOA abolishes infant-care behaviors in sibling marmosets without affecting other social or non-social behaviors. Amylin-expressing neurons in the marmoset MPOA are distributed in the vicinity of oxytocin neurons in the anterior paraventricular nucleus of the hypothalamus. While amylin infusion facilitates infant carrying selectively, an oxytocin’s inverse agonist, atosiban, reduces physical contact with non-infant family members without grossly affecting infant care. These data suggest that the amylin and oxytocin signaling mediate intrafamilial social interactions in a complementary manner in marmosets.
α-Synuclein emulsifies TDP-43 prion-like domain—RNA liquid droplets to promote heterotypic amyloid fibrils
Authors: Dhakal Shailendra , Mondal Malay , Mirzazadeh Azin , Banerjee Siddhartha , Ghosh Ayanjeet , Rangachari Vijayaraghavan 
Published: December 2023

AbstractMany neurodegenerative diseases including frontotemporal lobar degeneration (FTLD), Lewy body disease (LBD), multiple system atrophy (MSA), etc., show colocalized deposits of TDP-43 and α-synuclein (αS) aggregates. To understand whether these colocalizations are driven by specific molecular interactions between the two proteins, we previously showed that the prion-like C-terminal domain of TDP-43 (TDP-43PrLD) and αS synergistically interact to form neurotoxic heterotypic amyloids in homogeneous buffer conditions. However, it remains unclear if αS can modulate TDP-43 present within liquid droplets and biomolecular condensates called stress granules (SGs). Here, using cell culture and in vitro TDP-43PrLD – RNA liquid droplets as models along with microscopy, nanoscale AFM-IR spectroscopy, and biophysical analyses, we uncover the interactions of αS with phase-separated droplets. We learn that αS acts as a Pickering agent by forming clusters on the surface of TDP-43PrLD – RNA droplets. The aggregates of αS on these clusters emulsify the droplets by nucleating the formation of heterotypic TDP-43PrLD amyloid fibrils, structures of which are distinct from those derived from homogenous solutions. Together, these results reveal an intriguing property of αS to act as a Pickering agent while interacting with SGs and unmask the hitherto unknown role of αS in modulating TDP-43 proteinopathies.
Predicting Bordeaux red wine origins and vintages from raw gas chromatograms
Authors: Schartner Michael , Beck Jeff M. , Laboyrie Justine , Riquier Laurent , Marchand Stephanie , Pouget Alexandre 
Published: December 2023

AbstractConnecting chemical properties to various wine characteristics is of great interest to the science of olfaction as well as the wine industry. We explored whether Bordeaux wine chemical identities and vintages (harvest year) can be inferred from a common and affordable chemical analysis, namely, a combination of gas chromatography (GC) and electron ionization mass spectrometry. Using 12 vintages (within the 1990–2007 range) from 7 estates of the Bordeaux region, we report that, remarkably, nonlinear dimensionality reduction techniques applied to raw gas chromatograms recover the geography of the Bordeaux region. Using machine learning, we found that we can not only recover the estate perfectly from gas chromatograms, but also the vintage with up to 50% accuracy. Interestingly, we observed that the entire chromatogram is informative with respect to geographic location and age, thus suggesting that the chemical identity of a wine is not defined by just a few molecules but is distributed over a large chemical spectrum. This study demonstrates the remarkable potential of GC analysis to explore fundamental questions about the origin and age of wine.
Coupled mechanical oscillator enables precise detection of nanowire flexural vibrations
Authors: Sharma Maneesha , Sathyadharma Prasad Aniruddha , Freitag Norbert H. , Büchner Bernd , Mühl Thomas 
Published: December 2023

AbstractThe field of nanowire (NW) technology represents an exciting and steadily growing research area with applications in ultra-sensitive mass and force sensing. Existing detection methods for NW deflection and oscillation include optical and field emission approaches. However, they are challenging for detecting small diameter NWs because of the heating produced by the laser beam and the impact of the high electric field. Alternatively, the deflection of a NW can be detected indirectly by co-resonantly coupling the NW to a cantilever and measuring it using a scanning probe microscope. Here, we prove experimentally that co-resonantly coupled devices are sensitive to small force derivatives similar to standalone NWs. We detect force derivatives as small as 10−9 N/m with a bandwidth of 1 Hz at room temperature. Furthermore, the measured hybrid vibration modes show clear signatures of avoided crossing. The detection technique presented in this work verifies a major step in boosting NW-based force and mass sensing.
Upper mantle melt caused by a subducted slab in the Indian-Eurasian continental subduction zone
Authors: Li Guohui , Zhou Yuanze , Bai Ling , Gao Yuan , Li Yanan 
Published: December 2023

AbstractA low-velocity layer atop the mantle transition zone has been extensively observed worldwide. In subduction zones, this layer is widely explained as partial melting triggered by slab subduction on a regional or global scale. However, direct observational evidence is still absent, and the response of the layer to slab subduction is not well known. Here, we image the seismic velocity around the mantle transition zone by matching synthetic and observed triplicated seismic P and sP waveforms in the Indian–Eurasian continental subduction zone. Our observations reveal a laterally varied low-velocity layer atop the mantle transition zone beneath the Hindu Kush, where a subducted slab extends to the mantle transition zone. The geometric morphology of the low-velocity layer documents that it is a partially molten layer induced by the subducted slab on a regional scale. Interestingly, our observations also support that the layer has a low viscosity. The decreased viscosity may facilitate slab motion in the deep mantle, contributing to slab stretching, tearing and break-off and its resultant rare recurring large intermediate-depth earthquakes in an intracontinental setting.
f-Block reactions of metal cations with carbon dioxide studied by inductively coupled plasma tandem mass spectrometry
Authors: Cox Richard M , Melby Kali M. , French Amanda D. , Rodriguez Michael J. 
Published: December 2023

The reaction rates of lanthanide and actinide cations with CO2 are dictated by the crossing between the potential energy surface (PES) evolving from the ground state reactants (red) and the PES leading to the ground state products (green).
Handwritten and Typed Discourse in People With Aphasia: Reference Data for Sequential Picture Description and Comparison of Performance Across Modality
Authors: Obermeyer Jessica , Edmonds Lisa , Morgan Jodi 
Published: December 2023

Purpose:
Writing can be completed by hand or by typing. Increasingly, functional and social activities are completed in the virtual domain, which often requires discourse level writing. Yet, there is a shortage of research on discourse writing in aphasia. The purpose of this study was to provide preliminary reference data for a sequential picture description task in writing by hand and typing for people with aphasia. Additionally, we examined individual modality differences when comparing handwritten and typed discourse.

Method:
Fifteen people with mild–moderate aphasia participated in this study. They completed a sequential picture description task in handwriting and in typing. Discourse samples were coded for Correct Information Units (CIUs) and Complete Utterances. Measures of productivity were also evaluated (e.g., Total Words, Total Utterances). Participants completed a computer use questionnaire regarding their current and premorbid typing and computer use.

Results:
Preliminary reference data are reported. No significant differences were found at the group level for the measures evaluated. At the individual level, there was evidence of a modality effect for seven participants who demonstrated differences in the proportion of CIUs.

Conclusions:
Although preliminary, these findings suggest that, at the group level, the handwritten and typed discourse produced by people with mild–moderate aphasia is similar. However, at the individual level, there is potential for modality differences. Consistent patterns of premorbid computer use, difficulty ratings, and individual differences in writing modes were not identified for the participants who demonstrated a modality effect. However, there was preliminary evidence that poststroke handedness may contribute to modality differences exhibited by some participants, which should be explored in future research. Additionally, these reference data are preliminary and further research is required from a more heterogeneous group of people with aphasia and to better establish assessment practices for discourse writing.
Prevalence of Anxiety as a Variable in Treatment Outcomes for Individuals With Chronic Refractory Cough
Authors: Wright Miranda L. , Slovarp Laurie , Reynolds Jane , Roy Nelson , Okifuji Akiko , Sundar Krishna M. , Barkmeier-Kraemer Julie M. 
Published: December 2023

Purpose:
Anxiety is a mental state characterized by an intense sense of tension, worry, or apprehension relative to something adverse that might happen in the future. Anxiety is a known comorbidity in cough patients, yet its prevalence among those with chronic refractory cough (CRC) is unknown. Anxiety is not typically assessed during evaluation for CRC, but treatments for CRC such as neuromodulators and behavioral cough suppression therapy (BCST) may potentially attenuate anxiety. This preliminary study investigates the potential prevalence of anxiety in CRC and its possible role in treatment outcomes.

Method:
CRC patients seen in a specialty clinic at the University of Utah or the University of Montana completed the Leicester Cough Questionnaire (LCQ) pre- and post-BCST treatment. Participants were dichotomized into positive anxiety screen (PAS) and negative anxiety screen (NAS) groups based on presence or absence of documented anxiety within electronic medical records at the University of Utah and based on a Generalized Anxiety Disorder–7 score > 5 at the University of Montana.

Results:

Of the 86 total participants, 37 (43%) were in the PAS group (29 females,
M
age
= 56 ± 13) and 49 (57%) were in the NAS group (36 females,
M
age
= 64 ± 14). Eighty-nine percent of CRC participants with a PAS reported a clinically meaningful improvement in LCQ total score following treatment compared to 65% of NAS participants. Furthermore, mean pre- to posttreatment change scores on the LCQ were significantly greater within the PAS group (
p
= .002, Cohen's
d
= 0.7, indicating a moderate to large effect size).

Conclusion:
This preliminary study suggests that (a) anxiety may be prevalent among those with CRC and (b) those patients who screen positive for anxiety report greater benefit from BCST.
A novel hybrid centralised decentralised framework for electric vehicles coordination
Authors: Verma Praveen , Dasgupta Pallab , Chakraborty Chandan 
Published: December 2023

AbstractHybrid Centralised‐Decentralised Electric Vehicle (EV) coordination policy in the urgent charging scenario is presented. First, a robust and complex optimisation problem considering several key features affecting EV coordination is formulated. Then, a solution strategy for the formulated problem is proposed by decomposing the formulated problem into an EV coordination and simple optimisation problem. The decentralised rule‐based EV coordination strategy works on the principle of direct load flattening and utilises practical EV aggregator‐customer interaction, customer behaviour, and temporospatial shifting of the EVs to flatten the load duration curve at the charging station. Then, the centralised optimisation problem is solved to minimise the operation cost, decrease the power loss, and decrease congestion in the grid. A comparison between uncoordinated and coordinated charging in the case study conducted on the IEEE 24 bus system shows that the proposed approach reduces the average EV load by 1283.26 kW/min, average power loss by 2.465 kW/min, and operation cost by 61.99 $/min during the peak hours.
Abundance of strontium in the Galactic globular cluster 47 Tuc
Authors: Kolomiecas E. , Kučinskas A. , Klevas J. , Dobrovolskas V. 
Published: December 2023

Aims. We have determined Sr abundance in a sample of 31 red giant branch stars located in the Galactic globular cluster 47 Tuc with the aim to identify potential differences in the Sr abundance between first population (1P, Na-poor) and second population (2P, Na-rich) stars.
Methods. We derived the Na and Sr abundances from the archival spectra obtained with the UVES spectrograph. To do this, we used 1D ATLAS9 model atmospheres and a 1D local thermodynamic equilibrium spectral synthesis method. Particular attention was paid to assessing the potential impact of CN line blending on the obtained Sr abundances. Furthermore, we evaluated the potential influence of convection on the Sr line formation by using 3D hydrodynamical model atmospheres computed with the CO5 BOLD code.
Results. Our results suggest a weak correlation between the abundances of Sr and Na. Together with a similar correlation between the abundances of Zr and Na determined in our previous study, our analysis of Sr suggests that polluters that have enriched 2P stars with light elements may have produced some s-process elements as well. The mean Sr abundance determined in 31 red giant branch stars of 47 Tuc is ⟨[Sr/Fe]⟩ = 0.18 ± 0.08 (the error denotes the standard deviation due to the star-to-star abundance scatter). This value is within the range of the Sr abundance variation that is observed in Galactic field stars of similar metallicity. The mean [Sr/Zr] abundance ratio in our sample stars suggests that the two s-process elements could have been synthesized by either low-mass asymptotic giant branch stars (M = 1 − 4 M⊙) or massive (M = 10 − 20 M⊙) fast-rotating (vrot = 200 − 300 km s−1) stars.
Criteria for the assessment of the influence of atmospheric turbulence on wind turbine noise propagation
Authors: Kayser Bill , Écotière David , Gauvreau Benoit 
Published: December 2023

This paper investigates the influence of atmospheric turbulence on the propagation of wind turbine noise using an aeroacoustic source model coupled with a parabolic equation propagation model. Sets of simulations with and without atmospheric turbulence are performed, allowing the determination of a simple formulation that quantifies the uncertainties of the A-weighted sound pressure level (SPL) when the modelling does not account for atmospheric turbulence. For the case study, the results show that atmospheric turbulence has a negligible effect on SPL up to 800 m from the wind turbine, even under upwind conditions. While the conclusions are specific to this case study, the method appears promising for simplifying the calculation of atmospheric turbulence effect in wind turbine noise studies. A freely accessible online application has been developed to present additional results.
The oracle of D-A-Ch – Results of a Delphi Survey for the
development of the evidence- and consensus-based tool “My
Logbook”
Authors: Weiler-Wichtl Liesa J. , Kollmann Alina Stefanie , Fohn-Erhold Verena , Schneider Carina , Rosenmayr Verena , Hansl Rita , Hopfgartner Maximilian , Fries Jonathan , Herzog Kristina , Leiss Ulrike 
Published: December 2023

Abstract
Objective The present report describes the results of four delphi surveys
conducted within the quality improvement project “My Logbook”
which aims to translate evidence-based standards for psychosocial care in
pediatric oncology into a practical consensus-based tool.
Methods In four consecutive delphi surveys a total of n=153
international, multi-disciplinary experts rated the content, method, and design
of the different booklets of “My Logbook” which a local expert
group had conceptualized. After each survey, the feedback was incorporated, and
the changes were evaluated in a final consensus vote by the quality assurance
panel of the PSAPOH.
Results While some surveys led to a review on a page level, most booklets
as a whole reached the consensus-level of approval. Over the course of the
surveys, any revisions and comments were incorporated in the booklets, and
approval rates increased steadily.
Discussion The delphi surveys ensured the integration of
multi-disciplinary, international expertise, uncovering issues such as language
barriers and the need for a user manual that would not have been evident in
first line . The incorporation of the input led to a continuous improvement of
the tool, reflected in steadily increasing acceptance rates in the consecutive
survey rounds.
Conclusion The incorporation of the expert input as well as the additional
development of a user manual resulted in a final version of the “My
Logbook” apt for the interdisciplinary application in pediatric oncology
in the entire DACH-region.
Kognitive Einschränkungen nach einem Out-of-Hospital Cardiac
Arrest (OHCA)
Authors: Veelenturf J.M. , Passier P.E.C.A. , van Erp S. 
Published: December 2023

Zusammenfassung
Einleitung Die Überlebensrate in den Niederlanden bei einem
„Out-of-Hospital Cardiac Arrest“ ist in den letzten Jahrzehnten
gestiegen, was zum Teil auf den Einsatz von Bürgerhelfern und die
Verfügbarkeit von automatischen externen Defibrillatoren (AED)
zurückzuführen ist. Trotz dieser Entwicklungen sind
Hirnverletzungen nach einem OHCA immer noch ein großes und
häufiges Problem. 42–50% der Überlebenden leiden
an kognitiven Problemen, die oft unerkannt bleiben und ihre Alltagsfunktion,
gesellschaftliche Teilhabe und Lebensqualität erheblich
beeinträchtigen.
ZielFrühzeitige Erkennung von kognitiven Problemen bei
OHCA-Patienten während ihres Krankenhausaufenthalts. Dies soll Patienten
und ihren Angehörigen Informationen über mögliche
kognitive Probleme nach einem OHCA und deren Auswirkungen im Alltag
bereitstellen.
Methode Es wurde ein designorientierter Forschungsansatz in Kombination
mit dem Double-Diamond-Modell verwendet. Es handelte sich um einen iterativen
Prozess, der aus mehreren Forschungsphasen besteht. In jeder Forschungsphase
kamen verschiedene Forschungsmethoden zum Einsatz, wie z.B.
Fokusgruppeninterviews mit Pflegefachkräften (N=34) in
Kombination mit einer Post-it-Methode zur Spezifizierung von Wünschen
und Bedürfnissen.
ErgebnisseNeue Prototypen, darunter ein interdisziplinärer Ansatz,
eine Informationsbroschüre zu den Folgen nach einem Herzstillstand und
Schulungen zu kognitiven Problemen nach einem OHCA für das
Pflegepersonal wurden entwickelt und zeigen erste vielversprechende Ergebnisse.
Die Prototypen wurden vom medizinischen Fachpersonal und den Patienten positiv
aufgenommen. Die Schulung des medizinischen Personals führte zu mehr
Aufmerksamkeit für kognitive Probleme und könnte die
frühzeitige Erkennung fördern. Es gab jedoch einige
Herausforderungen, wie die Abstimmung von Empfehlungen zwischen Fachbereichen
und den Zeitpunkt für Konsultationen. Einige Patienten wünschten
sich eine mündliche Erklärung der Informationsbroschüre
durch den Arzt.
Fazit Eine interdisziplinäre Methode zur Erkennung und
Prüfung kognitiver Probleme während des Krankenhausaufenthalts
wurde entwickelt, erfolgreich umgesetzt und durch eine Pilotstudie getestet. Die
begrenzte Stichprobengröße und -dauer der Pilotstudie
könnten die externe Übertragbarkeit der Ergebnisse
einschränken. Trotz dieser Einschränkungen deuten die Ergebnisse
darauf hin, dass die implementierten Prototypen einen vielversprechenden Ansatz
zur Erkennung kognitiver Probleme bei OHCA-Patienten im Krankenhaus darstellen.
Empfehlungen zur Verbesserung der Prototypen, zur endgültigen
Implementierung, zur Sicherung und für Folgeuntersuchungen wurden
spezifiziert.
Neue therapeutische und supportive Optionen beim
Ovarialkarzinom
Authors: Holzhauer Peter 
Published: December 2023

ZusammenfassungDie vorliegende Kasuistik beschreibt der Therapieverlauf einer Patientin mit high
grade serösem Ovarialkarzinom, FIGO IIIB und BRCA1-Mutation und einer
Defizienz der homologen Rekombination. Die Standardtherapie nach aktueller
Leitlinie sieht hier 6 Zyklen Paclitaxel und Carboplatin in Kombination mit
Bevacizumab vor. Neu ist die mittlerweile etablierte Erhaltungstherapie mit
Bevacizumab in Kombination mit dem PARP-Inhibitor Olaparib. Diese
Kombinationstherapie ist indiziert bei den in diesem Fall vorliegenden
genetischen Veränderungen. Das supportive
komplementärmedizinische Nebenwirkungsmanagement fokussiert sich auf die
bei dieser Therapie wesentliche Nebenwirkung, die Chemotherapie-induzierte
Neuropathie (CIPN). Hier kommt mit der Hilotherapy® ein neues
apparatives Kühlungssystem zum Einsatz, dessen Effektivität in
mehreren Studien evaluiert wurde. Ergänzt wird dieser Ansatz durch die
systemische Behandlung mit Endocannabinoiden, antiinflammatorischen
Fettsäuren und alpha-Liponsäure.