bluuebunny/crossref_metadata_2025_split huggingface dataset:
Xây dựng công thức bào chế viên nén nổi acyclovir 100 mg
Authors: Nguyễn Thị Hoài Thương  , Võ Thế Anh Tài  , Nguyễn Minh Ngọc  
Published: February 2024

Acyclovir là thuốc kháng virus sử dụng trong điều trị các bệnh nhiễm trùng chủ yếu do virus Herpes simplex và Varicella Zoster gây ra. Tuy nhiên khi dùng theo đường uống thuốc có sinh khả dụng thấp (10 – 20) %, là do acyclovir có sinh khả dụng thấp. Do vậy, để hấp thu được tối ưu thì thuốc phải được giữ ở dạ dày. Nhằm cải thiện hiệu quả điều trị, tăng sinh khả dụng của thuốc, nghiên cứu này xây dựng công thức bào chế viên nén nổi acyclovir 100 mg. Nghiên cứu đã khảo sát sự ảnh hưởng của các tá dược kéo dài giải phóng (natri croscarmelose (NaCMC), carbopol, natri alginat, gôm xanthan) và các loại tá dược độn đến các chỉ tiêu chất lượng của cốm bán thành phẩm và viên nén. Kết quả thu được viên bào chế theo công thức CT12 với thành phần: acyclovir 100 mg và các tá dược NaCMC (50 mg), carbopol (50 mg), lactose (40 mg), Avicel PH 101 (40 mg), polyvinyl pirrolidon K30 (PVP K30) (20 mg), natri bicarbonat (100 mg) và magnesi stearat : talc 2 % (tỉ lệ 1:1) đã đạt các chỉ tiêu về độ đồng đều khối lượng, độ cứng, độ mài mòn, hàm lượng dược chất theo tiêu chuẩn DĐVN V, khả năng nổi trên 8 giờ và giải phóng kéo dài lên đến 8 giờ (94,90 %).
® 2023 Journal of Science and Technology - NTTU
Desempenho das diretrizes AGA, Fukuoka e Europeia nos incidentalomas mucinosos do pâncreas submetidos à ultrassonografia endoscópica com punção por agulha fina
Authors: Pacheco Débora Azeredo de Castro , Tabushi Fernando Issamu , Ardengh José Celso , Cuenca Ronaldo Mafia , Possiedi Rafael Dib , Manso Jose Eduardo Ferreira 
Published: February 2024

Introdução: As lesões císticas pancreáticas são comuns e não são exclusivamente benignas. Existem 3 diretrizes que ajudam a indicar cirurgia no caso de haver algum fator de risco, sinal de malignidade ou acompanhar o paciente com exames de imagem.
Objetivo: Revisar e comparar o desempenho dessas diretrizes em neoplasias mucinosas identificados de forma incidental.
Método: A revisão da literatura foi feita colhendo informações publicadas em plataformas virtuais em português e inglês. O material para leitura e análise foi selecionado das plataformas SciELO, Google Scholar, Pubmed e Scopus. Inicialmente foi realizada busca por descritores “neoplasia cística mucinosa. neoplasias intraductais pancreáticas. ultrassonografia endoscópica. aspiração por agulha fina” com busca AND ou OR, considerando o título e/ou resumo. Após, considerando-se somente os que tinham maior relação ao tema, foi realizada a leitura da íntegra dos textos.
Resultados: Foram incluídos 37 artigos.
Conclusão: A Diretriz Europeia- DE-2018 mostrou-se mais precisa para ser utilizada em pacientes com neoplasia mucinosa assintomática após o diagnóstico obtido pela USE-PAF.
Salud mental e infancia, emergencia que atender en el contexto migratorio, pero ¿quién o cómo se hará? Un reto posible
Authors: Güitrón Martínez Luisa Isabel 
Published: February 2024

La necesidad de atender y evitar un tsunami de alteraciones mentales originada por eventos traumatizantes en el periodo de desarrollo infantil debido a la migración forzada sea esta originada al huir de contextos de violencia, de guerra, de precariedad, o de la vulnerabilidad extrema ante la emergencia sanitaria, en una especie de rescate de salud mental post pandemia. La situación a nivel mundial que se vive, y la que se vislumbra hace necesario el desarrollo de un mayor número de habilidades a desarrollar en los seres humanos para poder avanzar en conjunto, y una sola red de profesionales, una sola sociedad no podrá hacerlo, pero si se incorporan fortalezas como los grupos de maestros, las trabajadoras sociales, las promotoras de salud (CHW) y se capacitan con un conjunto de conocimientos académicos, científicos y prácticos ya experimentados en su funcionalidad será más viable y mucho más estratégico para aproximarnos al futuro de una mejor manera. Por lo que la transferencia de habilidades que permitan la elaboración de protocolos y/o programas de intervención y promoción de salud mental será imprescindible para el buen desempeño en diversos espacios y modelos de atención como escuelas, promociones de desarrollo comunitario, etc. Sin lugar a duda el hecho de capacitar, y habilitar para que profesionales de otras áreas conozcan y manejen elementos de intervención, promoción y fortalecimiento de la salud mental, una especie de “traslado de tareas” facilitara un más sano desarrollo a nivel individual, familiar y comunitario. Así este estudio se presenta facilitando esa valiosa opción
Assessment of Gastrointestinal Parasite in Silver Catfish (Bagrus bayad; Forskal, 1775) from Ajiwa Reservoir Katsina State, Nigeria
Authors: Nababa Abdulsalam S , Umaru Joel , Sadauki M A , Sadauki A A 
Published: February 2024

Gastrointestinal parasite in Silver catfish was studied for six months between June 2022 and November 2022 to determine the prevalence of parasites infesting Bagrus bayad and the associated risk factors in Ajiwa reservoir Batagarawa, Katsina State, Nigeria. A total of 90 fish samples were collected and examined from Ajiwa reservoir, comprising 41 and 49 males and females, respectively. Observed parasites and their prevalence (%) in Bagrus bayad include: Cestode genera; Corallobothrium solidum 21 (23.86%), Pleurocercoid or Coradium sp. 8 (9.09%), Nematode genera; Capllaria philipinesis 31 (35.23%), Cammallanus sp 16 (18.18%), Procamallanus laevichonches 12 (13.64%). The prevalence of parasites recovered from the fish species in this study was high. In conclusion, Bagrus bayad in Ajiwa reservoir was susceptible to parasite infestation. It is recommended that this species of fish from the Ajiwa reservoir should be gutted before consumption to prevent zoonotic diseases.
Weiße Normalität.
Authors: Kißling Magdalena 
Published: February 2024

Die Studie befasst sich mit der Erweiterung des Gegenstandsbereichs postkolonialer Germanistik um rassismustheoretische Ansätze und legt Neuinterpretationen der kanonischen Texte Iphigenie auf Tauris (Goethe), Effi Briest (Fontane) und Tauben im Gras (Koeppen) vor. Im Fokus steht die Frage: Inwiefern produzieren, stabilisieren und subvertieren die Ästhetiken der Texte ein kulturelles Wissen über Weißsein, das zugleich durch interferierende vergeschlechtlichte und klassistische Diskurse gebrochen wird? Zusätzlich zu den kanonischen Texten bezieht die Studie in ihre postkolonialen Diskursanalysen einschlägige Unterrichtshilfen ein. Abschließend werden Perspektiven einer rassismussensiblen Literaturdidaktik entwickelt, die Diversitätsaspekte im Kontext von Methodik, Aufgabenkultur und Gesprächsführung berücksichtigen.

Reihe

Postkoloniale Studien in der Germanistik - Band 10
Poesie und Zeit
Authors: Widhammer Helmuth 
Published: February 2024

Theokrit gilt als Bukoliker. Diese Etikettierung wird der personalen, lokalen und thematischen Diversität, die vom Eros bis zu epochal bedeutsamen Ereignissen reicht, nicht zuletzt der stilistischen Vieltönigkeit der Eidyllien in keiner Weise gerecht. Deren Ausgangsgattung ist der syrakusische Mimos, der streiflichtartige Sketche mit verschiedenen Rollen auf die Volksbühne bringt. Nach dem Vorbild seines Landsmannes Sophron stilisiert Theokrit solche Szenen nach Maßgabe der poetischen Hochsprache; dabei geht es um das weitgreifende Programm einer methexis, einer Teilhabe aller sozialen Schichten am klassischen Erbe. Die Wahl bukolischer Motive bzw. bukolischer Einkleidungen auch dort, wo es um gar nicht Bukolisches geht, ist wiederum vielfältig motiviert und vom einzelnen Gedicht her zu analysieren.

Reihe

Aisthesis-Essay - Band 46
A Methodology for Ship Cabin Equipment Layout Considering Human Factor Reliability Optimization
Authors: Zhang Qiaoyu , Zhang Hongshuo , Lin Yan , Yang Yuansong , Liu Haiyang 
Published: February 2024

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The paper proposes an innovative methodology of Human Cognitive Reliability- Cognitive Reliability and Error Analysis Method (HCR-CREAM) coupled with A* search and genetic algorithm (GA) to tackle ship cabin equipment layout considering human factor reliability optimization with the goal of minimizing human error probability (HEP) subjected to practical requirements. After establishing the mathematical model of cabin equipment inspection tasks in ship cabin equipment layout problem through HCR-CREAM and equipment geometric simplification, a method of the horizontal movement based on minimum distance is presented to avoid the equipment overlapping, then A* search is used for planning inspection paths and GA with selection, crossover, and mutation operators is applied to solve equipment layout results. A case of equipment layout in a certain ship engine room has been taken to carry out parameter sampling experiments by Latin Hypercube for GA. The results show the solution effect of GA is less affected by its parameter variation. And through the comparison with the initial equipment layout, the indicators influencing the HEP of the optimized result have been improved, thus significantly reducing HEP.

Keywords
ship cabin equipment layout; human factor reliability optimization; HCRCREAM; A* search; genetic algorithm
Biocompósitos de ionômero de vidro reforçados com nanohidroxiapatita quimicamente reticulados com epicloridrina
Authors: Oliveira Borba Gabriel , Abreu Campolina Gustavo , Rodarte Abreu Araújo Lucas , Gonçalves da Silva Adriana , Pimenta de Araújo Cintia Tereza , Fernandes da Cunha Pereira Rodrigo David , César Dumont Vitor 
Published: February 2024

Apresentação Oral - II Congresso Internacional de Odontologia de Diamantina
O cimento de ionômero tornou se material de eleição pela Organização Mundial de Saúde (OMS) devido às suas propriedades de liberação de flúor, adesão à estrutura dentária e biocompatibilidade. Porém, apresentam limitações associadas à sua baixa resistência mecânica, sinérese e embebição. Assim, o objetivo deste estudo é modificar um cimento de ionômero de vidro convencional (GIC) com nanopartículas de fosfato de cálcio ((Hidroxiapatita e β-fosfato tricálcico (β-TCP)) (nCaP) e reticular com epicloridrina (ECH), bem como avaliar as propriedades mecânicas.Os resultados dos ensaios mecânicos de compressão e tração diametral foram submetidos ao teste de normalidade (Kolmogorov-Smirnov, p≥0,05), teste estatístico paramétrico (Levene) e em seguida post hoc Tukey. Os biocompositos modificados apresentaram maiores resultados em ambos os ensaios, apresentando diferença estatisticamente significativa em relação ao material precursor. Os biocompositos apresentaram melhorias das propriedades sendo promissores para uso clínico.
Timing of High-Energy Supplementation to Early-Season-Pasture-Forage Fed Continuous Culture
Authors: Felton E. E. D. , Krause K. M. 
Published: February 2024

A continuous culture study was conducted duplicating the daily meal pattern of pasture-grazed cattle and evaluating the time of two supplements differing in their composition (one complex: SUPP A and one simplistic: SUPP B) on their effects on nutrient digestion and metabolism of ruminal microorganisms. SUPP A contained ingredients containing substantial amounts of both structural and non-structural carbohydrates (NSC), fat, and protein, all having fractions with differing rates of availability. SUPP B’s predominate organic matter ingredients were only corn grain and soybean meal and contained approximately 3% less crude protein than SUPP A. All treatments were fed forage at five distinct times, mimicking forage intake on pasture, with supplements being fed at either a morning (AM) or evening (PM) feeding. The treatments were a) SUPP A fed AM, b) SUPP B fed AM, c) SUPP A fed PM, and d) Supp B fed PM. The results showed that dry matter, organic matter, and NSC digestibility’s were unaffected by supplement type or time of feeding. Supplement A showed greater fiber digestion than SUPP B, regardless of time of supplementation. The PM feeding decreased the digestion of both neutral detergent fiber and acid detergent fiber in SUPP B with no effect on fiber digestion in SUPP A. Culture pH remained more stable over the 24-hour day with SUPP B feeding than it did with SUPP A feeding while average pH was not affected by supplement or time of feeding. Total volatile fatty acid flow was unaffected by treatment, as were flows of acetic and propionic acids. Butyric acid flow decreased significantly on both supplements with the PM feeding. As expected, there were fewer total branch chain volatile fatty acids generated with SUPP B. Microbial growth measured in g microbial N flow/day increased for both supplements at the PM feeding. Flow of by-pass feed nitrogen was unaffected by supplement but was lower with PM feeding. Microbial efficiency was increased as a result of the PM feedings. The timing of a large amount of supplementation relative to the timing of daily forage meals can alter the effects seen in continuous culture work and may translate to effects in-vivo systems as well.
Amyloid β 38, 40, and 42 species in cerebrospinal fluid: More of the same?
Authors: Schoonenboom Niki S. , Mulder Cees , Van Kamp Gerard J. , Mehta Sangita P. , Scheltens Philip , Blankenstein Marinus A. , Mehta Pankaj D. 
Published: June 2005

AbstractVarious C‐terminally truncated amyloid β peptides (Aβ) are linked to Alzheimer's disease (AD) pathogenesis. Cerebrospinal fluid (CSF) concentrations of Aβ38, Aβ40, and Aβ42 were measured by enzyme‐linked immunosorbent assay in 30 patients with AD and 26 control subjects. CSF Aβ42 levels was decreased in patients with AD, whereas CSF Aβ38 and Aβ40 levels were similar in patients with AD and control subjects. All three Aβ peptides were interrelated, particularly CSF Aβ38 and Aβ40. Diagnostic accuracy of CSF Aβ42 concentrations was not improved by applying the ratios of CSF Aβ42 to Aβ38 or Aβ40. Ann Neurol 2005;58:139–142
Brain activation in offspring of AD cases corresponds to 10q linkage
Authors: Bassett Susan Spear , Kusevic Ivana , Cristinzio Catherine , Yassa Michael A. , Avramopoulos Dimitrios , Yousem David M. , Fallin M. Daniele 
Published: June 2005

AbstractPreviously, we reported evidence of genetic heterogeneity in late‐onset familial Alzheimer's disease, based on sex of affected parent, demonstrating linkage to chromosome 10q, a region identified by other groups and implicated as a quantitative trait loci for Aβ levels, in families with an affected mother. Using functional magnetic resonance imaging and a memory encoding task, we now show differential brain activation patterns among asymptomatic offspring which correspond to the previous linkage finding. These results suggest the possibility that activation patterns may prove useful as a preclinical quantitative trait related to the putative familial late‐onset AD gene in this chromosome 10 region. Ann Neurol 2005;58:142–146
Pre‐existing hypertension and the impact of stroke on cognitive function
Authors: Elkins Jacob S. , Yaffe Kristine , Cauley Jane A. , Fink Howard A. , Hillier Teresa A. , Johnston S. Claiborne 
Published: June 2005

AbstractHypertension has been associated with subclinical injury in the brain and may therefore increase the impact of an incident stroke on cognitive function. The Study of Osteoporotic Fractures (SOF) is a prospective, observational study of 9,704 women aged 65 years and older recruited from four U.S. metropolitan areas. Blood pressure was measured at study entry, and cognitive decline was defined by the change from prestroke to poststroke cognitive testing. During an average follow‐up of 6.8 years, incident stroke occurred in 260 participants (3.1%) who had previously completed baseline cognitive testing. Among participants with stroke, 119 completed follow‐up cognitive testing a median of 1.9 years after the stroke, 80 died before the next study visit, and 61 did not complete further cognitive testing. After adjustment for demographic factors and other confounders, pre‐existing hypertension was a strong predictor of cognitive decline when a stroke occurred (odds ratio [OR], 4.07; 95% confidence interval [CI], 1.37–12.1). In contrast, hypertension was only weakly associated with cognitive decline in the absence of stroke (OR, 1.13; 95% CI, 1.04–1.22) (p for interaction = 0.032). Pre‐existing hypertension in women is associated with a greater impact of stroke on cognitive function, possibly by influencing the ability to tolerate or recover from brain injury. Ann Neurol 2005;58:68–74
6‐Pyruvoyl‐tetrahydropterin synthase deficiency with mild hyperphenylalaninemia
Authors: Demos Michelle K. , Waters Paula J. , Vallance Hilary D. , Lillquist Yolanda , Makhseed Nawal , Hyland Keith , Blau Nenad , Connolly Mary B. 
Published: June 2005

AbstractSevere 6‐pyruvoyl‐tetrahydrobiopterin synthase deficiency is a tetrahydrobiopterin deficiency disorder that presents in infancy with developmental delay, seizures, and abnormal movements associated with hyperphenylalaninemia usually detectable by neonatal phenylketonuria screening programs. We describe an 8‐year‐old girl with delay, seizures, and dystonia with mild hyperphenylalaninemia detected in late childhood. The diagnosis of 6‐pyruvoyl‐tetrahydrobiopterin synthase deficiency was made by analysis of pterins in urine, pterins and neurotransmitters in cerebrospinal fluid, and enzyme assay. The patient improved clinically taking oral tetrahydrobiopterin, levodopa/carbidopa, and 5‐hydroxytryptophan. This treatable condition may not always be detected by routine population screening for hyperphenylalaninemia. Ann Neurol 2005;58:164–167
Spatial process modelling for univariate and multivariate dynamic spatial data
Authors: Gelfand Alan E. , Banerjee Sudipto , Gamerman Dani 
Published: June 2005

AbstractThere is a considerable literature in spatiotemporal modelling. The approach adopted here applies to the setting where space is viewed as continuous but time is taken to be discrete. We view the data as a time series of spatial processes and work in the setting of dynamic models, achieving a class of dynamic models for such data. We seek rich, flexible, easy‐to‐specify, easy‐to‐interpret, computationally tractable specifications which allow very general mean structures and also non‐stationary association structures.Our modelling contributions are as follows. In the case where univariate data are collected at the spatial locations, we propose the use of a spatiotemporally varying coefficient form. In the case where multivariate data are collected at the locations, we need to capture associations among measurements at a given location and time as well as dependence across space and time. We propose the use of suitable multivariate spatial process models developed through coregionalization.We adopt a Bayesian inference framework. The resulting posterior and predictive inference enables summaries in the form of tables and maps, which help to reveal the nature of the spatiotemporal behaviour as well as the associated uncertainty. We illuminate various computational issues and then apply our models to the analysis of climate data obtained from the National Center for Atmospheric Research to analyze precipitation and temperature measurements obtained in Colorado in 1997. Copyright © 2005 John Wiley & Sons, Ltd.
A numerical method for the Landau–Lifshitz equation with magnetostriction
Authors: Baňas L'ubomír 
Published: June 2005

AbstractWe present a numerical scheme for Landau–Lifshitz–Gilbert equation coupled with the equation of elastodynamics. The considered physical model describes the behaviour of ferromagnetic materials when magnetomechanical coupling is taken into account. The time‐discretization is based on the backward Euler method with projection. In the numerical approximation, the two equations are decoupled by a suitable linearization in order to solve the magnetic and mechanic part separately. The resulting semi‐implicit scheme is linear and allows larger time‐steps than explicit methods. We prove stability and error estimates for the presented time discretization in 2D. Finally, we test the accuracy of the scheme on an academic numerical example with known exact solution. Copyright © 2005 John Wiley & Sons, Ltd.
Strain localization in soft rock—a typical rate‐dependent solid: experimental and numerical studies
Authors: Bhandari A. R. , Inoue J. 
Published: June 2005

AbstractStrain localization developing inside soft rock specimens is examined through experimental observation and numerical simulation. In the experimental study, soft rock specimens are sheared at different strain rates under plane strain conditions and deformation and strain localization characteristics are analysed. Transition of localization mode from highly localized mode for higher strain rate to distributed and diffused mode of strain localization for lower strain rates was observed. In the numerical study, simulations of plane strain compression tests are carried out at different strain rates by using an overstressed‐type elasto‐viscoplastic model in finite element computations. The role of strain rates on setting gradients of strain fields across shear band is clarified. The probable mechanism for transition of localization mode is discussed. Copyright © 2005 John Wiley & Sons, Ltd.
Molecular structure and thickness dependence of chain orientation in aromatic polyimide films
Authors: Terui Yoshiharu , Matsuda Sho‐Ichi , Ando Shinji 
Published: June 2005

AbstractDegrees of orientation of main chains and imide rings were quantitatively estimated for spin‐coated films of six kinds of aromatic polyimides (PIs) using polarized attenuated total reflection (ATR)/Fourier transform infrared (FT‐IR) spectroscopy. The degrees of chain orientation parallel to the film planes are significantly larger for the PIs having rigid structures than those having flexible structures, and the introduction of side groups decrease the degrees of chain orientation. In contrast, the rotational orientations of imide rings are almost isotropic for all PI films. Moreover, the film thickness dependences of the degrees of orientation were investigated for two kinds of rigid‐rod PIs having bulky trifluoromethyl (CF3) side groups in their diamine moieties. The degrees of chain orientation slightly decrease as the film thickness increases, whereas the rotational orientation of imide rings is independent of the film thickness. The degrees of chain orientation on the substrate sides significantly differ from the atmospheric sides of PI films. This difference was generated during thermal imidization because of tensile stress originated from the mismatch in thermal expansion coefficients between the substrates and the PI films. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 2109–2120, 2005
Abnormal cholesterol biosynthesis in sitosterolaemia and the Smith‐Lemli‐Opitz syndrome
Authors: Salen G. , Shefer S. , Batta A. K. , Tint G. S. , Xu G. , Honda A. 
Published: June 2005

SummaryWe investigated the enzyme defects in two inherited disorders of cholesterol biosynthesis: sitosterolaemia and the Smith‐Lemli‐Opitz syndrome. In sitosterolaemic homozygotes, plasma plant sterols (sitosterol and campesterol) concentrations are elevated because of enhanced intestinal absorption and diminished removal. Underlying these changes is very low cholesterol biosynthesis to provide extra sterol for cell growth. Extremely reduced activities of HMG‐CoA reductase, the rate‐controlling enzyme for cholesterol biosynthesis, caused by deficient HMG‐CoA reductase mRNA is responsible and is the suspected inherited abnormality. The Smith‐Lemli‐Opitz syndrome is caused by a block in the last reaction in the cholesterol biosynthetic pathway, the conversion of 7‐dehydrocholesterol to cholesterol, which is catalysed by 7‐dehydrocholesterol Δ7‐reductase. As a result, low plasma and tissue cholesterol with high 7‐dehydrocholesterol levels are found in homozygotes, who show characteristic phenotypes of mental retardation, facial dysmorphism, and organ and limb congenital anomalies. Similar biochemical findings are produced in rats fed BM 15,766, an inhibitor of 7‐dehydrocholesterol Δ7‐reductase. Interestingly, feeding cholesterol can suppress abnormal cholesterol biosynthesis and improve symptoms in homozygotes and rats fed BM 15,766.