bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Predictive Immune and Metabolic Biomarkers of Tumor Microenvironment Regarding Pathological and Clinical Response in Esophageal Cancer After Neoadjuvant Chemoradiotherapy: A Systematic Review
Authors: Wang H. H. , Steffens E. N. , Kats-Ugurlu G. , van Etten B. , Burgerhof J. G. M. , Hospers G. A. P. , Plukker J. T. M. 
Published: September 2023

Abstract
Introduction
The tumor microenvironment (TME) plays a crucial role in therapy response and modulation of immunologic surveillance. Adjuvant immunotherapy has recently been introduced in post-surgery treatment of locally advanced esophageal cancer (EC) with residual pathological disease after neoadjuvant chemoradiotherapy (nCRT). F-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) remains a valuable imaging tool to assess therapy response and to visualize metabolic TME; however, there is still a paucity in understanding the interaction between the TME and nCRT response. This systematic review investigated the potential of TME biomarkers and 18F-FDG-PET/CT features to predict pathological and clinical response (CR) after nCRT in EC.

Methods
A literature search of the Medline and Embase electronic databases identified 4190 studies. Studies regarding immune and metabolic TME biomarkers and 18F-FDG-PET/CT features were included for predicting pathological response (PR) and/or CR after nCRT. Separate analyses were performed for 18F-FDG-PET/CT markers and these TME biomarkers.

Results
The final analysis included 21 studies—10 about immune and metabolic markers alone and 11 with additional 18F-FDG-PET/CT features. High CD8 infiltration before and after nCRT, and CD3 and CD4 infiltration after nCRT, generally correlated with better PR. A high expression of tumoral or stromal programmed death-ligand 1 (PD-L1) after nCRT was generally associated with poor PR. Moreover, total lesion glycolysis (TLG) and metabolic tumor volume (MTV) of the primary tumor were potentially predictive for clinical and PR.

Conclusion
CD8, CD4, CD3, and PD-L1 are promising immune markers in predicting PR, whereas TLG and MTV are potential 18F-FDG-PET/CT features to predict clinical and PR after nCRT in EC.
Systemic sclerosis – review of current data and latest reports
Authors: Kasperski Radosław , Łoś Tomasz , Sobstyl Anna , Dudziński Dominik , Piekarska-Kasperska Małgorzata 
Published: October 2023

Introduction: Systemic scleroderma (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs, vasculopathy and dysregulation of the immune system. It has the highest mortality rate among rheumatologic diseases. SSc causes high economic and social costs.
Aim of the study: The purpose of this review is to present the current state of knowledge and recent reports on the pathophysiology, clinical manifestation and treatment of SSc.
Materials and methods: A search was conducted using PubMed and GoogleScholar databases. Articles were searched in English using the following keywords: "systemic sclerosis", "scleroderma", "treatment", "symptoms", "pathophysiology".
Conclusions: Although the prognosis of SSc remains poor, optimized patient diagnosis along with ongoing advances in therapy could significantly impact the effectiveness of disease management in the near future. It is anticipated that there will be a growing need for further development of combination therapies to better treat this complex disease.
Intentional obesity reduction and the occurrence of gastric cancer – literature review
Authors: Gryta Jakub , Bielak Alicja , Iwan Karolina , Janczewska Martyna , Kania Konrad , Kalicka Maria , Krysa Tomasz , Kolasa Agata , Radziejowska Zuzanna , Szklarz Magdalena 
Published: October 2023

Introduction: Gastric cancer (GC) is one of most common cancers worldwide. Reducing exposure to risk factors, along with screening and early detection, are crucial for prevention. Many studies have linked obesity to GC. Weight loss can be achieved through proper diet and exercise. For patients with a body mass index (BMI) of 40 or higher, or 35 or higher with serious obesity-related comorbidities, bariatric surgery can be a means of weight reduction. This raises the question of whether intentional weight loss can lower the risk of GC in the population.
Purpose of the study: The aim of this study is to collect and summarize existing evidence on connection of bariatric surgery and lower GC risk and mortality in patients with obesity.
Material and method: Literature review was performed, in English databases, using keywords : cancer, gastric cancer, bariatric surgery, prevention, obesity, survival in gastric cancer.
Results and conclusion: It is widely recognized that obesity increases the risk of GC, and bariatric surgery is an effective method for weight reduction. Bariatric surgery is the most effective treatment for sustained weight loss and remission of obesity-related conditions. A systematic review conducted on this topic revealed that bariatric surgery is linked to a reduced risk of GC in patients with obesity. Compared to no surgery, bariatric surgery was found to be associated with significantly lower rates of obesity-associated cancer and cancer-related mortality. Weight loss after bariatric surgery provides significant health benefits.
Physical activity of patients with chronic kidney disease
Authors: Marczyk Klaudia , Berner Aleksandra , Stencel Katarzyna , Pękała Maciej , Olszewska Anna , Stelmaszak Karina , Polak Paulina , Polaszek Monika , Bogowska Marta , Matyja Karolina 
Published: October 2023

Introduction: The main causes of chronic kidney disease (CKD) are diabetic and hypertensive nephropathy. The incidence of civilization diseases is increasing, which also indirectly affects the increase in the incidence of CKD. The patient's therapy after the diagnosis should include the care of a multi-specialist therapeutic team that will remove as many restrictions as possible in everyday functioning and ensure a high quality of life. In addition to the selection of individual renal replacement therapy, i.a. physical rehabilitation. Despite the fact that in the course of chronic kidney disease physical activity is impaired by numerous pathophysiological processes, the patient should be encouraged to undertake physical activity in order to reduce the risk of death due to cardiovascular diseases, as well as to eliminate many other adverse health effects of the disease. The following paper aims to analyze the impact of physical activity on CKD patients and the pathophysiological causes of low physical activity in this group of patients and the possibility of implementing rehabilitation as an element of comprehensive therapy.
Aim of the study: To review the current literature on the physical activity of patients with chronic kidney disease
Materials and Methods: A review of the publications available in PubMed, using the key words „chronic kidney disease”, „psychical activity in chronic kidney disease”, physical activity”, „kidney failure”, „dialysis”, „renal rehabilitation”, „quality of life”
Melanoma - risk factors and prevention strategies
Authors: Magiera Barbara , Rybak Jakub , Magiera Karol 
Published: October 2023

Introductions and purpose: Melanoma is a malignant skin cancer, characterized by a very high rate of increase in the number of cases. The aim of this study is to analyze the key modifiable and non-modifiable risk factors associated with the development of melanoma and to discuss existing prevention strategies.
Materials and methods: A literature review was conducted using the "PubMed" database with the keywords "melanoma", "melanoma risk factors", "melanoma primary prevention" and “melanoma secondary prevention”.
State of knowledge: Melanoma risk factors can be divided into two groups: modifiable and non-modifiable. The main modifiable factor is UV radiation. Non-modifiable risk factors include: genetic factors, phenotypic characteristics, age, gender, and the presence of melanocytic nevi. UV radiation is responsible for the incidence of 60-70% of melanomas. Reducing exposure to risk factors is crucial in primary prevention, while self-examination and medical examination are important in secondary prevention.
Summary: Despite the very high rate of increase in the number of cases, morbidity and mortality associated with melanoma can be effectively reduced by adhering to the principles of primary and secondary prevention. Patient education is crucial to reduce exposure to modifiable factors and increase vigilance against new skin lesions.
We Fly Congress: Market Actions as Corporate Political Activity in the U.S. Airline Industry
Authors: Pang Min-Seok , Funk Russell J. , Hirschman Daniel 
Published: October 2023

The literature on corporate political activity (CPA) generally views nonmarket actions aimed at influencing political actors (e.g., lobbying or campaign contributions) as related but separate activities from market actions. This study demonstrates how firms’ core market actions (e.g., market entry or geographic expansion) can function as CPA. We theorize two mechanisms through which firms leverage market actions as CPA: “pork” (i.e., ones that primarily benefit a politician’s constituents) and “perk” (i.e., ones that directly benefit the politician). We document these mechanisms through an empirical analysis of data from the U.S. airline industry in 1990–2019. Specifically, we find that airlines increase the supply of flights from the airports in the home district of the chair of the Transportation Committee in the U.S. House of Representatives (pork). We also find that the airlines increase the supply of nonstop flights to Washington, DC. from the Chair’s district (perk). We use counterfactual estimation methods and exogenous turnovers in committee leadership to provide causal evidence. Moreover, the observed increase in flight supplies is negatively associated with formal policy changes in Congress, and with text mining techniques, we find that this effect is stronger for bills related to aviation safety and security. We contribute to the literature on CPA by demonstrating a blurred boundary between market and nonmarket actions, which helps explain firms’ competitive actions that cannot be explained by market considerations alone. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.17026 .
Food-induced brain activity in adult obesity: a quantitative electroencephalographic study
Authors: Abdurrohim Kemas , Soewondo Pradana , Witjaksono Fiastuti , Mihardja Hasan , Indriatmi Wresti , Wibowo Heri , Handayani Selfi , Ibrahim Nurhadi 
Published: October 2023

BACKGROUND Obesity may be associated with declined food consumption control through neurological and behavioral processes, as well as heightened responsiveness of the brain’s reward systems. Performing neuroimaging and neurophysiological methods such as electroencephalography (EEG) can examine the connection between brain function and behavior. This study aimed to identify brain regulation of feeding behavior to food cues, which could be a potential neuromodulatory intervention target in adult obesity.
METHODS This cross-sectional study was conducted at Cipto Mangunkusumo Hospital, Jakarta, involving 40 adults with obesity. EEG analysis was performed to measure electrophysiological brain activity during eyes-open condition and during exposure to high-calorie food cues. Student’s t-tests were performed to identify any significant differences between the groups (p<0.05).
RESULTS Beta waves in the frontal (channel F7) and gamma waves in the central (channels C3 and C4) and parietal (channels P3 and P4) regions were significantly increased during food cues compared to resting state/eyes-open condition without stimulation. Theta waves in the frontal (channels F7 and F8), central (channel C3), and parietal (channels P3 and P4) regions and alpha waves in the central (channels C3 and C4) and parietal (channels P3 and P4) regions were significantly decreased during food cues compared with resting state.
CONCLUSIONS In adults with obesity, increased beta activity in the frontal and gamma in the central and parietal regions suggested increased food-cue awareness and heightened attentional focus toward food stimuli. Additionally, decreased alpha and theta activities in frontal regions could underline deficits in executive functions and higher motivation.
Optical remote imaging via Fourier ptychography
Authors: Tian Zhiming , Zhao Ming , Yang Dong , Wang Sen , Pan An 
Published: October 2023

Combining the synthetic aperture radar (SAR) with the optical phase recovery, Fourier ptychography (FP) can be a promising technique for high-resolution optical remote imaging. However, there are still two issues that need to be addressed. First, the multi-angle coherent model of FP would be destroyed by the diffuse object; whether it can improve the resolution or just suppress the speckle is unclear. Second, the imaging distance is in meter scale and the diameter of field of view (FOV) is around centimeter scale, which greatly limits the application. In this paper, the reasons for the limitation of distance and FOV are analyzed, which mainly lie in the illumination scheme. We report a spherical wave illumination scheme and its algorithm to obtain larger FOV and longer distance. A noise suppression algorithm is reported to improve the reconstruction quality. The theoretical interpretation of our system under random phase is given. It is confirmed that FP can improve the resolution to the theoretical limit of the virtual synthetic aperture rather than simply suppressing the speckle. A 10 m standoff distance experiment with a six-fold synthetic aperture up to 31 mm over an object of size ∼1  m×0.7  m is demonstrated.
PENGARUH KOLOID NANOPERAK TERHADAP PERKEMBANGAN EMBRIO IKAN WADER PARI (Rasbora lateristriata, Bleeker, 1854)
Authors: Arrusyda Muthia , Retnoaji Bambang 
Published: October 2023

Industrialisasi produk dengan bahan nanoperak semakin meningkat. Salah satu metode sintesis nanoperak (AgNPs) yang ramah lingkungan adalah radiosintesis menggunakan sinar gamma. Tantangan lingkungan terkait industrialisasi AgNPs tidak hanya terkait sintesis dan produksi tetapi juga terkait penggunaan produk. Peningkatan penggunaan nanoperak juga berarti peningkatan limbah pemakaian produk dengan nanoperak yang terpapar ke ekosistem perairan. Tujuan penelitian ini adalah untuk mengetahui bagaimana pengaruh koloid nanoperak terstabilisasi alginat terhadap daya tetas telur dan struktur tulang ikan wader pari (Rasbora lateristriata, Bleeker, 1854). Koloid AgNPs disintesis menggunakan sinar gamma pada dosis 5 KGy, 10 KGy, 15 KGy, dan 20 KGy kemudian dikarakterisasi dengan UV-Vis. Telur ikan didedahkan dengan koloid AgNPs selama 24 jam. Embrio diamati pada umur 2 hari menggunakan mikroskop leica. Pewarnaan tulang dilakukan dengan pewarna Alizarin Red dan Alcian Blue pada ikan berusia 5 pekan. Terdapat penurunan daya tetas embrio ikan wader pari pada perlakuan AgNPs yang disitesis pada 5 KGy. Morfologi jantung pada larva megalami edema. Osifikasi pada bagian kranial ikan dengan perlakuan terlihat mengalami keterlambatan jika dibandingkan dengan normal. Terdapat penurunan laju jantung pada ikan perlakuan. Pendedahan AgNPs pada fase embrio ikan wader dapat memengaruhi sistem sirkulasi, struktur tulang dan daya tetas embrio ikan wader pari.
CHARACTERIZATION AND IDENTIFICATION OF SM4 BACTERIAL ISOLATE FROM Stylissa massa SPONSE AS PRODUCING ANTIMICROBIAL COMPOUNDS AGAINST PATHOGENIC BACTERIA
Authors: Pardosi Lukas 
Published: October 2023

East Nusa Tenggara (NTT) is one of the archipelagic provinces in Indonesia with a sea area of 200,000 km² and contains potential marine resources including the Stylissa massa sponge. Bacteria have been known to associate with sponges and have the ability to produce antimicrobial compounds. This study aims to characterize, identify the 16S rRNA gene, and test the bioactive compounds of SM4 bacterial isolates from the Stylissa massa sponge. The bacterial isolates of SM4 were previously rejuvenated on NA medium, then characterized by macroscopic morphology, and biochemistry by citrate test and TSIA test. The culture was extracted using petroleum ether solvent and the antibacterial activity was tested against E. coli and S. aureus by the well method. The isolates were then identified based on the 16S rRNA gene by PCR method. The results showed that, SM4 isolates had small colony size, yellow color, round colony shape, flat elevation, flat margins, while biochemically they had positive results with Citrate and TSIA tests. The antagonist test of the SM4 bacterial isolate was found to have the ability to inhibit the growth of S. aureus and E. coli, while the antibacterial activity test of the bioactive compound bacterial isolate SM4 was known to have the ability to inhibit the growth of S .aureus with an inhibition zone of 1.99 mm and E. colli 1.56 mm. The results of the molecular identification of the bacterial isolate SM4 had 99% similarity with the Bacillus cereus strain Nr_074540.1
Performance of Endoscopic Sleeve Gastroplasty by Obesity Class in the Clinical United States Setting
Authors: Gala Khushboo , Brunaldi Vitor , McGowan Christopher , Sharaiha Reem Z. , Maselli Daniel , Vanderwel Brandon , Kedia Prashant , Ujiki Michael , Wilson Eric , Vargas Eric J. , Storm Andrew C. , Abu Dayyeh Barham K. 
Published: October 2023

Abstract

Introduction:
Endoscopic sleeve gastroplasty (ESG) has gained popularity over the past decade and has been adopted in both academic and private institutions globally. We present outcomes of the largest cohort of patients from the United States undergoing ESG and evaluate these according to obesity class.

Methods:
We performed a retrospective analysis of adult patients who underwent ESG. Medical information was abstracted from the electronic record with weight records up to two years after ESG. Percent total body weight loss (%TBWL) at 6, 12, 18, and 24 months were calculated based on baseline weight at procedure. SPSS (version 29.0) was used for all statistical analyses.

Results:
A total of 1506 patients from 7 sites were included (501 Class I obesity, 546 Class II and 459 with Class III). Baseline demographics differed according to obesity class due to differences in age, BMI, height, sex distribution, and race. As early as 6 months post ESG, mean BMI for each class dropped to the next lower class and remained there through 2 years. %TWBL achieved in the Class III group was significantly greater when compared with other classes at all time points. At 12 months, 83.2% and 60.9% of patients had ≥10% and ≥ 15% TBWL for all classes. There were no differences in adverse events between classes.

Conclusion:
Real world data from a large cohort of patients of all BMI classes across the US shows significant and sustained weight loss with ESG. ESG is safe to perform in a higher obesity class with acceptable mid-term efficacy.
Bioakumulasi Logam Berat Pb oleh Chlorella vulgaris
Authors: Putriany Altysia , Widianingsih Widianingsih , Endrawati Hadi , Hartati Retno 
Published: October 2023

Usaha untuk menghilangkan logam berat merupakan suatu proses pengolahan air limbah yang sangat penting. Beberapa metode telah dilakukan baik dengan metode kimia maupun fisika, namun perlakuan secara biologi dianggap lebih murah dan aefektif. Chlorella vulgaris merupakan salah satu jenis mikroalga yang mempunyai kemampuan menyerap dan menghilangkan logam berat seperti timbal (Pb) di air limbah. Penelitian ini bertujuan untuk mengetahui pengaruh logam berat timbal (Pb) pada media pemeliharaan yang berbeda terhadap pertumbuhan dan bioakumulasinya pada C. vulgaris. . Metode eksperimen laboratorium dengan lima perlakuan konsentrasi logam berat timbal (Pb) pada media budidaya C vulgaris yang berbeda, yaitu 0, 25, 50, 75, dan 100 ppm. Setiap perlakuan dengan tiga ulanga. Mikroalga C. vulgaris dikultur selama 7 hari dan pada akhir penelitian kepadatannya dihitung dan kandungan Pbnya dianalisa dengan menggunakan Atomic Absorption SpectrophotometerHasil penelitian menunjukkan bahwa semakin tinggi konsentrasi Pb pada media, semakin menghambat pertumbuhan C. vulgaris. C. vulgaris mampu mengakumulasi logam Pb dengan efisiensi penyerapannya sebesar 0,34% pada konsentrasi 100 ppm. Analisis varian memperlihatkan konsentrasi Pb memberikan pengaruh yang nyata (p<0,05) pada pertumbuhan, dan kemampuan akumulasi Pb pada C. vulgaris. In the wastewater treatment process, the removal of heavy metals is very important. The process has applied various chemical and physical methods, and the biological method is believed to be the most efficient and cheapest. Chlorella vulgaris is one species of microalgae that has ability to absorb and accumulate heavy metals such as lead (Pb). Chlorella can grow in extreme environments and withstand outside influences, better than other types of microalgae. This study aims to determine the influence of lead (Pb) in the culture media on the growth and bioaccumulation of C. vulgaris. The laboratory experiment method was applied with several Pb concentrations in the culture media of C. vulgaris, i.e. 0, 25, 50, 75, and 100 ppm. The treatments were triplicated. The C. vulgaris was cultured for seven days, and in the end of the experiment, the density was counted, and the Pb was analyzed using Atomic Absorption Spectrophotometer The results showed that the higher concentrations of Pb in the culture media gave the most inhibiting growth of C. vulgaris. C. vulgaris accumulate Pb at a concentration of 100 ppm in the culture media with an absorption efficiency of 0.34%. It revealed that the difference in Pb concentration give significant effect (p<0.05) on the growth and Pb accumulation capability of C. vulgaris.
The Impact and Prediction of Shoreline Dynamics in Pekalongan, Indonesia
Authors: Ayasy Muhammad Farras , Helmi Muhammad , Zainuri Muhammad , Kunarso Kunarso , Rochaddi Baskoro 
Published: October 2023

Shoreline in Pekalongan has changed and impacted land use significantly. This research investigates historical changes in shoreline dynamics and their impact on land use from 2003–2021. This research also examines the trend of shoreline prediction for 2031–2041. Multitemporal SPOT5 and SPOT6 satellite images were used as primer data to detect shoreline and land use changes. The DSAS (Digital Shoreline Analysis System) analyzes the shoreline change and generates shoreline prediction. This research shows that the coastal areas of Pekalongan have been impacted by erosion, with 528.08 hectares of area and 56.33 hectares of accretion. The North Pekalongan sub-district is the worst area hit by erosion. The shoreline has retreated 2405.8 meters with a 353.3 m/year erosion rate. Several areas of land use were heavily affected by erosion trends, such as ponds, rice fields, and open land. Shoreline predictions generated by DSAS were heavily reliant on historical rates of shoreline change dynamics. The predicted area of the shoreline is estimated to retreat 49.9–466.2 meters from the existing position in the next 10 and 20 years. This research is expected to provide information to local governments for evaluating the maintenance and development planning of the coastal area