bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel extraperitoneal cesarean section of supravesical approach: Operative techniques
Authors: Kotsuji Fumikazu , Hosono Sayoko , Nishikawa Shigeki , Shibata Takashi , Kato Hiroki , Nakago Satoshi , Oishi Tetsuya 
Published: November 2023

AbstractAimWe have established a novel extraperitoneal cesarean section technique by supravesical approach. An advantage of this technique over the conventional paravesical approach is that the lower uterine segment is broadly exposed and that all operative procedures can be performed under direct vision. We present the details of this novel technique.MethodsThe bladder and the peritoneum are exposed by removing the transversalis and extraperitoneal fasciae. Subsequently, a triangular area between the median umbilical ligament, the peritoneum, and the bladder is exposed. The median umbilical ligament is dissected at this site. Bladder dissection from the peritoneum is also initiated from this area and proceeds toward the lower uterine segment.ResultsOperative times for pelvic fascia dissection and bladder removal from the peritoneal surface are currently around 15–25 min. During the process of development of this technique, there have been no bladder injuries in 501 patients that caused urine leakage.DiscussionThe supravesical approach has been considered difficult due to the strong adhesion between the perivesical fascia and the peritoneum at the bladder fundus. In this paper, we show how to safely remove the bladder fundus from the peritoneum. The bladder can then be easily lowered down toward the lower uterine segment. Although this technique allows the lower uterine segment to be broadly exposed and all operative procedures can be performed under direct vision, a disadvantage is the comparatively long time currently required to perform it.ConclusionsThis technique could be a valuable option for extraperitoneal cesarean section, but disadvantages must also be considered.
Artificial intelligence systems in dental shade‐matching: A systematic review
Authors: Shetty Sthithika , Gali Sivaranjani , Augustine Dominic , SV Sowmya 
Published: November 2023

AbstractPurposeUses for artificial intelligence (AI) are being explored in contemporary dentistry, but artificial intelligence in dental shade‐matching has not been systematically reviewed and evaluated. The purpose of this systematic review was to evaluate the accuracy of artificial intelligence in predicting dental shades in restorative dentistry.MethodsA systematic electronic search was performed with the databases MEDLINE (PubMed), Scopus, Cochrane Library, and Google Scholar. A manual search was also conducted. All titles and abstracts were subject to the inclusion criteria of observational, interventional studies, and studies published in the English language. Narrative reviews, systematic reviews, case reports, case series, letters to the editor, commentaries, studies that were not AI‐based, studies that were not related to dentistry, and studies that were related to other disciplines in dentistry, other than restorative dentistry (prosthodontics and endodontics) were excluded. Two investigators independently evaluated the quality assessment of the studies by applying the Joanna Briggs Institute Critical Appraisal Checklist for Quasi‐Experimental Studies (non‐randomized experimental studies). A third investigator was consulted to resolve the lack of consensus.ResultsFifty‐three articles were initially found from all the searches combined from articles published from 2008 till March 2023. A total of 15 articles met the inclusion criteria and were included in the systematic review. AI algorithms for shade‐matching include fuzzy logic, a genetic algorithm with back‐propagation neural network, back‐propagation neural networks, convolutional neural networks, artificial neural networks, support vector machine algorithms, K‐nearest neighbor with decision tree and random forest, deep learning for detection of dental prostheses based on object‐detection applications, You Only Look Once‐YOLO. Moment invariant was used for feature extraction. XG (Xtreme Gradient) Boost was used in one study as a gradient‐boosting machine learning algorithm. The highest accuracy in the prediction of dental shades was the decision tree regression model for leucite‐based dental ceramics of 99.7% followed by the fuzzy decision of 99.62%, and support vector machine using cross‐validation of 97%.ConclusionsLighting conditions, shade‐matching devices and color space models, and the type of AI algorithm influence the accuracy of the prediction of dental shades. Knowledge‐based systems and neural networks have shown better accuracy in predicting dental shades.
Socioeconomic impacts of Russian invasion of Ukraine: A multiregional assessment for Europe
Authors: Almazán‐Gómez Miguel Ángel , Llano Carlos , Pérez Julián , Rauhut Daniel 
Published: November 2023

AbstractHistory shows that wars can be enormously disruptive of economic activity, especially international trade, national income, and global economic welfare. This article analyzes the impact on the European regions the Russian invasion of Ukraine using the largest and most updated multiregional input‐output model for Europe. Two shocks, trade and inflation, and four alternative scenarios are simulated. The scenarios are considered regarding the number of countries applying a trade embargo, the exemption of oil and gas, and the potential trade diversions with third countries such as China. We obtained a significant fall in GDP (−1.7%), 3.7 m lost jobs and 3% raise over the prewar inflation rate. For trade shock, large indirect effects are obtained, indicating the high relevance of the sectors and countries exposed to the war and the sanctions. The republics of the former Soviet Union, as well as the satellite countries of the former communism, face the harshest adverse impacts. This work shows the importance of breaking Russia's colonial economic ties to the countries in Eastern Europe.
Community engagement through social media: A promising low‐cost strategy for rural recruitment?
Authors: Vos Sarah C. , Adatorwovor Reuben , Roberts Michelle K. , Sherman Deanna Lee , Bonds Delaney , Dunfee Madeline N. , Spring Bonnie , Schoenberg Nancy E. 
Published: November 2023

AbstractPurposeFor the same reasons that rural telehealth has shown promise for enhancing the provision of care in underserved environments, social media recruitment may facilitate more inclusive research engagement in rural areas. However, little research has examined social media recruitment in the rural context, and few studies have evaluated the feasibility of using a free social media page to build a network of rural community members who may be interested in a research study. Here, we describe the rationale, process, and protocols of developing and implementing a social media approach to recruit rural residents to participate in an mHealth intervention.MethodsInformed by extensive formative research, we created a study Facebook page emphasizing community engagement in an mHealth behavioral intervention. We distributed the page to local networks and regularly posted recruitment and community messages. We collected data on the reach of the Facebook page, interaction with our messages, and initiations of our study intake survey.FindingsOver 21 weeks, our Facebook page gained 429 followers, and Facebook users interacted with our social media messages 3,080 times. Compared to messages that described desirable study features, messages that described community involvement resulted in higher levels of online interaction. Social media and other recruitment approaches resulted in 225 people initiating our in‐take survey, 9 enrolling in our pilot study, and 26 placing their names on a waiting list.ConclusionsA standalone social media page highlighting community involvement shows promise for recruiting in rural areas.
Implementation of equine‐assisted intervention for older adults with Alzheimer's disease residing in a nursing home: Brakes and levers
Authors: Badin Léa , Bailly Nathalie , Pennequin Valérie 
Published: November 2023

AbstractObjectiveAlthough research on equine‐assisted intervention (EAI) for older adults is beginning to be published, no scientific study has examined the various elements that can limit or facilitate the implementation of EAI with older adults suffering from Alzheimer's disease (AD) residing in nursing homes. The aim of this study was to identify the possible brakes and levers of implementing EAI with AD patients. A focus on professional affiliation was conducted.MethodThe survey was posted online on 2 February 2021 via the Sphinx software. As this study was aimed at gerontology professionals working in nursing homes, they were contacted through various specialized social networks. A total of 663 people answered the survey.ResultsThe results indicate that for 45% of the participants, the main brake to implementing EAI is related to the institutional burden. As for the levers, 29% of the people indicated that it would mainly be beneficial due to the cognitive stimulation that EAI would provide. People who were not familiar with EAI reported more brakes to its implementation. Finally, it was observed that the caregivers were those who put forward the most levers for the implementation of EAI with AD patients living in nursing homes.ConclusionThus, this study allows us to understand some of the reasons why nursing homes are reluctant to set up EAI. Communication on this subject is currently a lever to be developed.Implications for practiceBy highlighting the brakes and levers on the implementation of EAIs, we are able to identify suitable guidelines for developing this type of intervention in nursing homes, which could be used as a complement to nursing care to help Alzheimer’s patients overcome physical or psychological health problems.
Regional anesthesia and sickle cell crisis in pediatric patients: An educational‐focused review
Authors: Elhamrawy Amr , Veneziano Giorgio , Tobias Joseph D. 
Published: November 2023

AbstractIntroductionSickle cell disease (SCD) is the most common inherited hemoglobinopathy, affecting approximately 100 000 patients in United States and millions worldwide. Although the mainstay of pain management for VOC remains systemic opioids, given the potential for adverse effects including respiratory depression and hypoxemia, there remains interest in the use of regional anesthetic techniques (neuraxial or peripheral nerve blockade).MethodsA systematic search of pubMed, Scopus, and Google Scholar was conducted using the terms sickle cell disease, sickle cell crisis, pain crisis, vaso‐occlusive crisis, regional anesthesia, peripheral nerve blockade, and neuraxial anesthesia.ResultsWe identified 7 publications, all of which were retrospective case series or single case reports, outlining the use of neuraxial anesthesia in a total of 26 patients with SCD. Additionally, we identified 4 publications, including one retrospective case series and 3 single case reports, entailing the use of peripheral blockade in patients with VOC and SCD.DiscussionThe available literature, albeit all retrospective or anecdotal, suggests the potential utility of regional anesthesia to treat pain in patients with SCD. Additional benefits have included avoidance of the potential deleterious physiologic effects of systemic opioids and in one case series, an improvement in respiratory function as judged by pulse oximetry. The anecdotal and retrospective nature of the available reports with an absence of prospective trials limits the evidence based medicine available from which to develop to guidlines for the optimal local anesthetic agent to use, its concentration, the rate of infusion, and the choice of adjunctive agents.
GW9 determines grain size and floral organ identity in rice
Authors: Wen Yi , Hu Peng , Fang Yunxia , Tan Yiqing , Wang Yueying , Wu Hao , Wang Junge , Wu Kaixiong , Chai Bingze , Zhu Li , Zhang Guangheng , Gao Zhenyu , Ren Deyong , Zeng Dali , Shen Lan , Dong Guojun , Zhang Qiang , Li Qing , Xiong Guosheng , Xue Dawei , Qian Qian , Hu Jiang 
Published: November 2023

SummaryGrain weight is an important determinant of grain yield. However, the underlying regulatory mechanisms for grain size remain to be fully elucidated. Here, we identify a rice mutant grain weight 9 (gw9), which exhibits larger and heavier grains due to excessive cell proliferation and expansion in spikelet hull. GW9 encodes a nucleus‐localized protein containing both C2H2 zinc finger (C2H2‐ZnF) and VRN2‐EMF2‐FIS2‐SUZ12 (VEFS) domains, serving as a negative regulator of grain size and weight. Interestingly, the non‐frameshift mutations in C2H2‐ZnF domain result in increased plant height and larger grain size, whereas frameshift mutations in both C2H2‐ZnF and VEFS domains lead to dwarf and malformed spikelet. These observations indicated the dual functions of GW9 in regulating grain size and floral organ identity through the C2H2‐ZnF and VEFS domains, respectively. Further investigation revealed the interaction between GW9 and the E3 ubiquitin ligase protein GW2, with GW9 being the target of ubiquitination by GW2. Genetic analyses suggest that GW9 and GW2 function in a coordinated pathway controlling grain size and weight. Our findings provide a novel insight into the functional role of GW9 in the regulation of grain size and weight, offering potential molecular strategies for improving rice yield.
RING‐type E3 ligase BnaJUL1 ubiquitinates and degrades BnaTBCC1 to regulate drought tolerance in Brassica napus L
Authors: Hu Jin , Luo Mudan , Zhou Xianming , Wang Zhaoyang , Yan Li , Hong Dengfeng , Yang Guangsheng , Zhang Xiaohui 
Published: November 2023

AbstractDrought stress poses a persistent threat to field crops and significantly limits global agricultural productivity. Plants employ ubiquitin‐dependent degradation as a crucial post‐translational regulatory mechanism to swiftly adapt to changing environmental conditions. JUL1 is a RING‐type E3 ligase related to drought stress in Arabidopsis. In this study, we explored the function of BnaJUL1 (a homologous gene of JUL1 in Brassica napus) and discovered a novel gene BnaTBCC1 participating in drought tolerance. First, we utilised BnaJUL1‐cri materials through the clustered regularly interspaced short palindromic repeats (CRISPR)‐CRISPR‐associated protein 9 system. Second, we confirmed that BnaJUL1 regulated drought tolerance through the drought tolerance assay and transcriptome analysis. Then, we identified a series of proteins interacting with BnaJUL1 through yeast library screening, including BnaTBCC1 (a tubulin binding cofactor C domain‐containing protein); whose homologous gene TBCC1 knockdown mutants (tbcc1‐1) exhibited ABA‐sensitive germination in Arabidopsis, we then confirmed the involvement of BnaTBCC1 in drought tolerance in both Arabidopsis and Brassica. Finally, we established that BnaJUL1 could ubiquitinate and degrade BnaTBCC1 to regulate drought tolerance. Consequently, our study unveils BnaJUL1 as a novel regulator that ubiquitinates and degrades BnaTBCC1 to modulate drought tolerance and provided desirable germplasm for further breeding of drought tolerance in rapeseed.
Narrowband ultraviolet B phototherapy combined with intralesional injection of either latanoprost or platelet‐rich plasma for stable nonsegmental vitiligo
Authors: Fawzy Manal , Al‐Mokadem Sahar , Alshereef Mabrokah , Elkholy Basma 
Published: November 2023

AbstractBackgroundNarrowband ultraviolet B (NB‐UVB) phototherapy is the cornerstone of vitiligo treatment. Its combination with other treatments usually yields a better response. Latanoprost, a prostaglandin F2α analog, and autologous platelet‐rich plasma (PRP) have been reported to be effective for vitiligo.AimTo evaluate the efficacy of NB‐UVB combined with intralesional latanoprost or PRP for stable nonsegmental vitiligo (NSV).MethodsSixty patients with stable NSV were recruited and randomly allocated to two equal groups. NB‐UVB phototherapy was administered twice a week for all patients. Additionally, group A received intralesional latanoprost injections once weekly, while group B received intralesional autologous PRP injections every 2 weeks.ResultsAt 24 weeks, excellent repigmentation response was observed in 26.7% and 13.3% of patients in the latanoprost/NB‐UVB and PRP/NB‐UVB groups, respectively, with no significant difference in degrees of repigmentation between the two groups. However, the Vitiligo Extent Score for a Target Area (VESTA) score was significantly higher in the latanoprost/NB‐UVB group (p = .032). Moreover, lesions located on nonacral skin responded significantly better than those on acral skin. Only erythema was significantly higher in the PRP/NB‐UVB group, while the recurrence of depigmentation was significantly higher in the latanoprost/NB‐UVB group.ConclusionsBoth latanoprost and PRP have the potential to be effective add‐on therapies to NB‐UVB phototherapy for stable NSV, with latanoprost resulting in a greater repigmentation response and PRP producing a more stable response.
Transcription factors dealing with Iron‐deficiency stress in plants: focus on the bHLH transcription factor family
Authors: Zhang Zhongxing , Cheng Jiao , Wang Wanxia , Gao Yanlong , Xian Xulin , Li Cailong , Wang Yanxiu 
Published: November 2023

AbstractIron (Fe), as an important micronutrient element necessary for plant growth and development, not only participates in multiple physiological and biochemical reactions in cells but also exerts a crucial role in respiration and photosynthetic electron transport. Since Fe is mainly present in the soil in the form of iron hydroxide, Fe deficiency exists universally in plants and has become an important factor triggering crop yield reduction and quality decline. It has been shown that transcription factors (TFs), as an important part of plant signaling pathways, not only coordinate the internal signals of different interaction partners during plant development, but also participate in plant responses to biological and abiotic stresses, such as Fe deficiency stress. Here, the role of bHLH transcription factors in the regulation of Fe homeostasis (mainly Fe uptake) is discussed with emphasis on the functions of MYB, WRKY and other TFs in the maintenance of Fe homeostasis. This review provides a theoretical basis for further studies on the regulation of TFs in Fe deficiency stress response.
Extended platelet‐rich fibrin
Authors: Miron Richard J. , Pikos Michael A. , Estrin Nathan E. , Kobayashi‐Fujioka Masako , Espinoza Alan Rene , Basma Hussein , Zhang Yufeng 
Published: November 2023

AbstractPlatelet‐rich fibrin (PRF) has been characterized as a regenerative biomaterial that is fully resorbed within a typical 2–3 week period. Very recently, however, a novel heating process was shown to extend the working properties of PRP/PRF from a standard 2–3 week period toward a duration of 4–6 months. Numerous clinicians have now utilized this extended‐PRF (e‐PRF) membrane as a substitute for collagen barrier membranes in various clinical applications, such as guided tissue/bone regeneration. This review article summarizes the scientific work to date on this novel technology, including its current and future applications in periodontology, implant dentistry, orthopedics and facial aesthetics. A systematic review was conducted investigating key terms including “Bio‐Heat,” “albumin gel,” “albumin‐PRF,” “Alb‐PRF,” “extended‐PRF,” “e‐PRF,” “activated plasma albumin gel,” and “APAG” by searching databases such as MEDLINE, EMBASE and PubMed. Findings from preclinical studies demonstrate that following a simple 10‐min heating process, the transformation of the liquid plasma albumin layer into a gel‐like injectable albumin gel extends the resorption properties to at least 4 months according to ISO standard 10 993 (subcutaneous animal model). Several clinical studies have now demonstrated the use of e‐PRF membranes as a replacement for collagen membranes in GTR/GBR procedures, closing lateral windows in sinus grafting procedures, for extraction site management, and as a stable biological membrane during recession coverage procedures. Furthermore, Alb‐PRF may also be injected as a regenerative biological filler that lasts extended periods with advantages in joint injections, osteoarthritis and in the field of facial aesthetics. This article highlights the marked improvement in the stability and degradation properties of the novel Alb‐PRF/e‐PRF technology with its widespread future potential use as a potential replacement for collagen membranes with indications including extraction site management, GBR procedures, lateral sinus window closure, recession coverage among others, and further highlights its use as a biological regenerative filler for joint injections and facial aesthetics. It is hoped that this review will pioneer future opportunities and research development in the field, leading to further progression toward more natural and less costly biomaterials for use in medicine and dentistry.
Impedance cardiogram based exploration of cardiac mechanisms in post‐traumatic stress disorder during trauma recall
Authors: Sheikh Shafa‐at Ali , Shah Amit J. , Bremner J. Douglas , Vaccarino Viola , Inan Omer T. , Clifford Gari D. , Rad Ali Bahrami 
Published: November 2023

AbstractPost‐traumatic stress disorder (PTSD) is an independent risk factor for developing heart failure; however, the underlying cardiac mechanisms are still elusive. This study aims to evaluate the real‐time effects of experimentally induced PTSD symptom activation on various cardiac contractility and autonomic measures. We recorded synchronized electrocardiogram and impedance cardiogram from 137 male veterans (17 PTSD, 120 non‐PTSD; 48 twin pairs, 41 unpaired singles) during a laboratory‐based traumatic reminder stressor. To identify the parameters describing the cardiac mechanisms by which trauma reminders can create stress on the heart, we utilized a feature selection mechanism along with a random forest classifier distinguishing PTSD and non‐PTSD. We extracted 99 parameters, including 76 biosignal‐based and 23 sociodemographic, medical history, and psychiatric diagnosis features. A subject/twin‐wise stratified nested cross‐validation procedure was used for parameter tuning and model assessment to identify the important parameters. The identified parameters included biomarkers such as pre‐ejection period, acceleration index, velocity index, Heather index, and several physiology‐agnostic features. These identified parameters during trauma recall suggested a combination of increased sympathetic nervous system (SNS) activity and deteriorated cardiac contractility that may increase the heart failure risk for PTSD. This indicates that the PTSD symptom activation associates with real‐time reductions in several cardiac contractility measures despite SNS activation. This finding may be useful in future cardiac prevention efforts.
The role of the Praenotamenta of Jodocus Badius Ascensius in shaping early modern dramatic criticism
Authors: Torello‐Hill Giulia 
Published: November 2023

AbstractThis article examines the profound and enduring legacy of the treatise on classical drama known as Praenotamenta ascensiana in shaping early modern dramatic poetics. Written by Flemish scholar Jodocus Badius Ascensius (1462–1535) as a preface to his 1502 edition of the Classical plays of Terence, this work has been unjustly overlooked by the critics that have invariably credited Aristotle’s Poetics for foregrounding the debate on early modern dramatic criticism, following Alessandro de Pazzi’s first Latin translation (1536) and Francesco Robortello’s monumental commentary (1548). The purpose of Praenotamenta was to provide educators, students and playwrights with a concise and accessible compendium of ancient dramatic poetics. This treatise circulated widely across Europe and helped disseminate ideas that became central to early modern discourse on poetics, such as verisimilitude and decorum, as well as discussion on the didactic and civic role of poetry. Blended with Aristotelian doctrine, these concepts became the tenets of late sixteenth‐century poetics treatises in England, France, Italy and Spain.