bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coupling state‐of‐the‐art modelling tools for better informed Red List assessments of marine fishes
Authors: Grüss Arnaud , Winker Henning , Thorson James T. , Walker Nicola D. , Maureaud Aurore , Pacoureau Nathan 
Published: February 2024

Abstract

In the face of biodiversity loss worldwide, it is paramount to quantify species' extinction risk to guide conservation efforts. The International Union for the Conservation of Nature (IUCN)'s Red List is considered the global standard for evaluating extinction risks. IUCN criteria also inform national extinction risk assessments. Bayesian models, including the state‐of‐the‐art JARA (‘Just Another Red List Assessment’) tool, deliver probabilistic statements about species falling into extinction risk categories, thereby enabling characterisation and communication of uncertainty in extinction risk assessments.

We coupled the state‐of‐the‐art VAST (‘Vector Autoregressive Spatio‐Temporal’) modelling tool and JARA, for better informed Red List assessments of marine fishes. In this framework, VAST is fitted to scientific survey catch rate data to provide indices to JARA whose uncertainty is propagated to JARA outcomes suggesting extinction risk categories (under the population reduction criterion). In addition, VAST delivers a valuable habitat assessment to better understand what may be driving extinction risk in the study region. Here, we demonstrate the coupled VAST‐JARA modelling framework by applying it to five contrasting North Sea species, with or without a quantitative stock assessment and with different conservation statuses according to the latest global Red List assessments.

The North Sea application coupled with previous assessments and studies suggest that, among the three elasmobranchs, starry ray is in most need of urgent research (and conservation actions where appropriate), followed by spurdog, while lesser‐spotted dogfish is increasing in biomass. Moreover, both the VAST‐JARA modelling framework and previous research indicate that, while European plaice is not of conservation concern, cod has likely met the IUCN criteria for being listed as Endangered recently.

Synthesis and applications. The predictions of the VAST‐JARA modelling framework for North Sea species, including JARA output and VAST habitat assessment, constitute valuable supporting information to make interpretations based on Red List guidelines, which will help decision‐makers in their next North Sea Red List assessment. We foresee applications of the modelling framework to assist Red List assessments of numerous marine fishes worldwide. Our modelling framework has many potential advantageous uses, including informing resource management about climate change impacts on species' extinction risks.
Aiming at the ‘proper’ body: How exoskeletons foster ‘risky’ bodies and conflicting knowledge regimes
Authors: Butnaru Denisa 
Published: February 2024

AbstractExoskeletal devices are new technologies that have been developed in the medical field to provide assistance and rehabilitation for persons with motor impairments. Among these impairments, spinal cord injury and stroke are the most common. Drawing on materials collected during multi‐sited ethnography conducted in France, Germany and Switzerland from 2014 to 2019, I suggest that exoskeletons contribute to a more general process that I identify as ‘aiming at the “proper” body’. As they materially craft motor impaired bodies but also are responsible for datafication and dataveillance, exoskeletons allow to categorise new aspects of ‘risky’ bodies. Simultaneously, they foster conflicts between experts’ perspectives about rehabilitation practice and the users’ phenomenological experiences that exoskeletons aim to transform. After describing how exoskeletons expand the realm of contemporary medical technologies in their purpose of ‘aiming at “proper” bodies’ while being ‘miraculous’, I identify two conceptions of ‘risky’ bodies: a first one related to materiality, a second one to processes of digitalisation to which exoskeletons actively participate. Finally, I investigate some conflicting levels between the regimes of expert knowledge and the phenomenological experiences of the users and reassess the latter’s role in rehabilitation practice with exoskeletons.
The impact of natural resource rent, global value chain participation, and financial development on environmental footprints: A global analysis with fresh evidence
Authors: Guan Xuemei , Wang Qian , Mansoor Hira , Nadeem Muhammad 
Published: February 2024

AbstractThe motivation for conducting this research is the growing awareness of the increasing number of environmental issues on a global scale. As the world is facing the necessity of tackling environmental degradation, this study intends to uncover the fundamental links between global value chain participation, financial development, and their aggregate influence on environmental footprints in the context of the global economies (selected 60 countries) from 1996 to 2018. This study utilized a modern and novel technique known as the “Quantile Autoregressive Distributed Lagged Model.” The research results revealed that, in the selected economies, more natural resource rent, better financial development, and greater participation in the global value chain all positively contributed to environmental degradation across different quantiles. This implies an increasing environmental burden because of higher financial development, enhanced global value chain participation, and rising rents for natural resources. The study's findings have important policy implications, stressing the need for authorities or policymakers to incorporate environmental concerns into economic and financial policies. The authors also recommended that governments should think about enacting laws that support environmentally conscious behavior, such as rewarding investments in eco‐friendly technology and penalizing actions that harm the environment.
Economic and environmental impact of green infrastructures on developing economies: Pakistan a case in point
Authors: Babar Abdul Haseeb Khan , Ali Yousaf , Gohar Ali 
Published: February 2024

AbstractEnvironmental concerns are pressing nations worldwide to embrace greener and sustainable practices in every field. However, the existence of old unplanned cities devoid of greenery and rapid rates of urbanization are becoming a major source of pollution and a constant thorn in the sight of a sustainable future. To deal with these problems, different types of green infrastructures (GI) are introduced in developed nations. Nevertheless, these infrastructures require proper planning and economic investments for implementation, which is a huge hindrance to their adoption in developing countries. Therefore, this study aims to plan and analyze the impact of GI on the environment and the economy if it is introduced in a developing country like Pakistan. Geographic information system is used to analyze the current level of greenery and plan the installation of a new GI in one of the major cities of Pakistan. Furthermore, the reduction in carbon emissions, the environmental and economic benefits of different types of GI are measured and compared with the cost of implementation using techno‐economic analysis. Finally, the payback period and internal rate of return are calculated to check the return of the initial investment. The results show that the economic and environmental benefits of GI surpass the cost of installation by a great margin. Therefore, GI can be a feasible option for sustainable development in other developing countries. The economic and environmental analysis on the practical case study of a developing country like Pakistan are the prime novelties of this study.
Strategies to detect trace methamphetamine contamination on hard surfaces: Assessing realistic performance of commercially available presumptive tests and a laboratory‐based LC–MS/MS method
Authors: Naviaux William , Hedman Curtis , Barkholtz Heather 
Published: February 2024

AbstractRecreational methamphetamine production and heavy use can result in dwelling contamination that is difficult to detect. First responders and public health officials may use commercially available trace methamphetamine detection (presumptive) test kits to understand apparent and hidden dangers in impacted dwellings. Here, we assessed the limit of detection (LOD) of several commercially available presumptive test kits using simulated contaminated hard surfaces. Pyrex petri dishes were spiked with aliquots of methanolic methamphetamine solutions to reach desired simulated contamination levels. Commercially available presumptive tests were conducted according to manufacturer instructions and using included sample preparation materials, when available. Additionally, a laboratory‐based liquid chromatography‐triple quadrupole mass spectrometer (LC–MS/MS) trace methamphetamine quantification method was developed and validated using the EZSTATSG2 tool. For the LC–MS/MS method, samples were collected using 2‐ply alcohol prep pads and methamphetamine was extracted using a 1:1 (v:v) methanol: water solution. Most presumptive tests considered were able to detect trace levels of methamphetamine extracted from hard surfaces, with LOD ranging from 0.10–15.00 μg/sample. Comparatively, the laboratory‐based LC–MS/MS LOD was 0.05 μg/sample and limit of quantitation was 0.10 μg/sample. The LC–MS/MS method may be useful when the presence of dust or other contaminants interferes with presumptive test interpretation or reliability. Costs of presumptive tests varied from several dollars to tens of dollars, which is included alongside LOD results to aid stakeholders in identifying which test(s) are the best fit for purpose. Therefore, first responders, public health officials, and other stakeholders have several options for assessing trace methamphetamine contamination.
Comparative analysis of immunotherapy responses in small cell lung cancer patients with dermatomyositis
Authors: Kim So‐yun , Kim Duk Ki , Choi Song‐Yi , Chung Chaeuk 
Published: February 2024

AbstractCancer‐associated dermatomyositis (CAD), a paraneoplastic syndrome characterized by dermatomyositis (DM), frequently presents in association with small cell lung cancer (SCLC). Although the advent of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, their efficacy and safety in patients with concurrent autoimmune diseases (AD) and malignancies remains uncertain. Several studies have suggested the safe administration of ICIs in patients with AD, indicating that successful cancer therapy can alleviate CAD symptoms. Conversely, other studies have raised concerns about the potential for ICIs to exacerbate AD flares or immune‐related adverse events (irAEs). A comparative analysis of two cases from our institution emphasizes the variability in ICI responses among SCLC patients with CAD. One patient, previously reported as a case study, exhibited significant clinical improvement in DM symptoms after ICI administration, whereas the other developed severe exfoliative skin changes and experienced an unfavorable prognosis. This variability emphasizes the need for careful patient selection and close monitoring during ICI treatment. We hypothesized that overweight or obese individuals and those with severe initial skin lesions and elevated lactate dehydrogenase levels are more susceptible to developing irAEs following ICI therapy. Therefore, caution is advised when considering immunotherapy in these patients.
N‐Isopropylbenzylamine‐induced conditioned place preference, sensitization behaviour and self‐administration in rodents
Authors: Lai Miaojun , Fu Dan , Li Xiangyu , Zhuang Dingding , Wang Majie , Xu Zeming , Liu Huifen , Shen Haowei , Xu Peng , Zhou Wenhua 
Published: February 2024

AbstractN‐Isopropylbenzylamine (N‐ipb), a chain isomer of methamphetamine (METH) with similar physical properties, has been used as a substitute for METH in seized drug samples. However, the abuse potential of N‐ipb remains unclear. Therefore, this study aimed to evaluate the abuse potential of N‐ipb in comparison to METH, by using conditioned place preference (CPP), locomotor sensitization and intravenous self‐administration tests. The results showed that N‐ipb at a dose of 3 mg·kg−1 significantly induced CPP in mice, which was comparable to the effect of METH at 1 mg·kg−1. Either acute or repeated N‐ipb injections (1 or 3 mg·kg−1) failed to raise the locomotor activity. However, acute treatment with 10 mg·kg−1 N‐ipb elevated the locomotor activity compared with saline, while chronic injection of 10 mg·kg−1 N‐ipb induced a delayed and attenuated sensitization compared with 1 mg·kg−1 METH. Rats could acquire N‐ipb self‐administration at a dose of 1 mg·kg−1·infusion−1, and a typical inverted U‐shaped dose–response curve was obtained for N‐ipb. The mean dose of N‐ipb that maintained the maximum response was greater than that of METH, indicating that N‐ipb is less potent for reinforcement than METH. In the economic behavioural analysis, comparison of essential values derived from the demand elasticity revealed that N‐ipb is less efficacy as a reinforcer than METH. The present data demonstrate that N‐ipb functions as a reinforcer and has a potential for abuse. However, the potency of psychomotor stimulation and the reinforcing effectiveness of N‐ipb are lower than those of METH.
Can revenue index insurance outperform yield index insurance?
Authors: Gallenstein Richard A. , Dougherty John P. 
Published: February 2024

AbstractIndex insurance programs in developing countries have focused almost entirely on agricultural production risk (i.e., yield) while largely avoiding output marketing risk (i.e., price). This omission may miss an important constraint on smallholder investment and may partially explain underwhelming demand for yield‐based insurance policies. Here, we explore the viability of an area‐revenue index insurance policy and how its performance may compare to that of an area‐yield index insurance policy. Using data from Ghana, we estimate reduced‐form regression analysis and calibrate a simulation model, generating several important results. We show that there is a negative correlation between farm investment and covariate price risk. Moreover, our simulation predicts that in many market contexts, area‐revenue index insurance suffers from less basis risk, exhibits higher demand, and is more effective at crowding in advanced input adoption compared to area‐yield index insurance. Our results also demonstrate important contexts in which area‐yield index insurance outperforms area‐revenue index insurance. We therefore find that revenue insurance may be a valuable and impactful product in Ghana but would not outperform area‐yield index insurance in all contexts.
Expedience and experimentation: John Maynard Keynes and the politics of time
Authors: Eich Stefan 
Published: February 2024

AbstractJohn Maynard Keynes is often seen as the quintessential thinker of the short run, calling on us to focus our intellectual and material resources on the present. This poses an intriguing puzzle in light of Keynes's own influential speculations about the future. I use this seeming tension as an opening into Keynes's politics of time, both as a crucial dimension of his political thought and a contribution to debates about political temporality and intertemporal choice. Keynes's insistence on radical uncertainty translated into a skepticism toward intertemporal calculus as not only morally objectionable but also at risk of undermining actual future possibilities. Instead of either myopic presentism or calculated futurity, Keynes advocated bold experimentation in the present to open up new possibilities for an uncertain future. This points to the need to grapple with how to align multiple overlapping time horizons while appreciating the performativity of competing conceptions of the future.
Urged to feel certain again: The role of emotion‐related impulsivity on the relationships between intolerance of uncertainty and OCD symptom severity
Authors: Xu Junjia , Ironside Manon L. , Broos Hannah C. , Johnson Sheri L. , Timpano Kiara R. 
Published: February 2024

AbstractObjectivesObsessive–compulsive disorder (OCD) is a debilitating mental disorder characterized by persistent and intrusive thoughts accompanied by repetitive mental or physical acts. While both intolerance of uncertainty and emotion‐related impulsivity have been consistently evidenced as cognitive risk factors of OCD, no studies have considered their joint effects. The current study examined the interaction between intolerance of uncertainty and two forms of emotion‐related impulsivity—including both a behavioural and cognitive form—in predicting OCD symptoms.DesignCross‐sectional data were collected online from community‐based adult participants.MethodsParticipants (N = 673) completed a battery of self‐report measures of OCD symptom severity, intolerance of uncertainty, and emotion‐related impulsivity.ResultsThe behavioural form of emotion‐related impulsivity positively moderated the relationship between intolerance of uncertainty and OCD symptoms. Elevated levels of both factors predicted the most severe symptoms, particularly checking, washing, and obsessing. This interaction effect was not found for the cognitive form of emotion‐related impulsivity, which still emerged as a unique predictor of OCD symptom severity, specifically obsessing symptoms.ConclusionsCurrent findings furthered the understanding of the link between intolerance of uncertainty and OCD symptoms by highlighting the role of emotion‐related impulsivity. When uncertainty triggers distress in individuals with high intolerance of uncertainty, the urge to behaviourally alleviate this distress could promote the use of maladaptive obsessions and compulsions, leading to greater OCD symptoms. Results also indicated the potentially differential effects from the behavioural versus cognitive forms of emotion‐related impulsivity on different symptom domains, and the mechanistic link here is worthy of further investigation.
Thromboembolic events, major bleeding and mortality in essential thrombocythaemia and polycythaemia vera—A matched nationwide population‐based study
Authors: Enblom‐Larsson Anneli , Renlund Henrik , Andréasson Björn , Holmberg Henrik , Liljeholm Maria , Själander Anders 
Published: February 2024

SummaryThromboembolic events and bleeding are known complications in essential thrombocythaemia (ET) and polycythaemia vera (PV). Using multiple Swedish health care registers, we assessed the rate of arterial and venous events, major bleeding, all‐cause stroke and all‐cause mortality in ET and PV compared to matched controls. For each patient with ET (n = 3141) and PV (n = 2604), five matched controls were randomly selected. In total, 327 and 405 arterial or venous events were seen in the group of ET and PV patients respectively. Compared to corresponding controls, the rate of venous thromboembolism, major bleeding and all‐cause mortality per 100 treatment years was significantly increased among both ET (0.63, 0.79 and 3.70) and PV patients (0.94, 1.20 and 4.80). The PV patients also displayed a significantly higher rate of arterial events and all‐cause stroke compared to controls. When dividing the cohort into age groups, we found a significantly higher rate of arterial and venous events in all age groups of PV patients, and the rate of all‐cause mortality was significantly higher in both ET and PV patients in all ages above the age of 50. This study confirms that PV and ET are diseases truly marked by thromboembolic complications and bleeding.
Novel phenotype associated with homozygous likely pathogenic variant in the POP1 gene
Authors: Michelson Marina , Yosovich Keren , Bahar Sarit , Yogev Yuval , Birk Ohad S. , Ginzberg Mira , Lev Dorit 
Published: February 2024

AbstractThe biallelic variants of the POP1 gene are associated with the anauxetic dysplasia (AAD OMIM 607095), a rare skeletal dysplasia, characterized by prenatal rhizomelic shortening of limbs and generalized joint hypermobility. Affected individuals usually have normal neurodevelopmental milestones. Here we present three cases from the same family with likely pathogenic homozygous POP1 variant and a completely novel phenotype: a girl with global developmental delay and autism, microcephaly, peculiar dysmorphic features and multiple congenital anomalies. Two subsequent pregnancies were terminated due to multiple congenital malformations. Fetal DNA samples revealed the same homozygous variant in the POP1 gene. Expression of the RMRP was reduced in the proband compared with control and slightly reduced in both heterozygous parents, carriers for this variant. To our knowledge, this is the first report of this new phenotype, associated with a novel likely pathogenic variant in POP1. Our findings expand the phenotypic spectrum of POP1‐related disorders.
2‐Hydroxyethyl methacrylate (2‐HEMA) sensitization, a global epidemic at its peak in Spain?
Authors: Gatica‐Ortega Maria Elena , Pastor‐Nieto Maria Antonia , Giménez‐Arnau Ana María , Mercader‐García Pedro , Sanz‐Sánchez Tatiana , Carrascosa‐Carrillo José Manuel , Córdoba‐Guijarro Susana , Sánchez‐Pérez Javier , Silvestre Juan Francisco , Frutos Francisco Javier Ortiz‐de , Tous‐Romero Fátima , Fernández‐Redondo Virginia , Serra‐Baldrich Esther , Ruíz‐González Inmaculada , González Pérez Ricardo , Miquel‐Miquel Javier , Guillén Paloma Sánchez‐Pedreño , Hervella‐García Marcos , Heras‐Mendaza Felipe , Gómez‐de‐la‐Fuente Enrique , Zaragoza‐Ninet Violeta , Gilo Araceli Sánchez , Rodríguez‐Serna Mercedes , Melé‐Ninot Gemma , Descalzo Miguel Ángel , de‐Vega Marina , García‐Doval Ignacio , Borrego Leopoldo 
Published: February 2024

AbstractBackgroundA global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products.ObjectivesTo evaluate the frequency of sensitization to 2‐hydroxyethyl methacrylate (2‐HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates.MethodsFrom January 2019 to December 2022, 2‐HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres.ResultsSix thousand one hundred thirty‐four patients were consecutively patch tested with 2‐HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable ‘occupational’ was found to be significantly associated with a higher risk for relevant positive reactions to 2‐HEMA (OR: 10.9; 95% CI: 8.1–14.9).Conclusion(Meth)acrylate sensitization is a prevalent health issue in Spain. 2‐HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means.