bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to work after hospitalization for sepsis: a nationwide, registry-based cohort study
Authors: Skei Nina Vibeche , Moe Karoline , Nilsen Tom Ivar Lund , Aasdahl Lene , Prescott Hallie C. , Damås Jan Kristian , Gustad Lise Tuset 
Published: November 2023

Abstract
Background
Sepsis survivors commonly experience functional impairment, which may limit return to work. We investigated return to work (RTW) of patients hospitalized with sepsis and the associations with patient and clinical characteristics.

Methods
Working-age patients (18–60 years) admitted to a Norwegian hospital with sepsis between 2010 and 2021 were identified using the Norwegian Patient Registry and linked to sick-leave data from the Norwegian National Social Security System Registry. The main outcome was proportion of RTW in patients hospitalized with sepsis at 6 months, 1 year, and 2 years after discharge. Secondary outcomes were time trends in age-standardized proportions of RTW and probability of sustainable RTW (31 days of consecutive work). The time trends were calculated for each admission year, reported as percentage change with 95% confidence interval (CI). Time-to-event analysis, including crude and adjusted hazard risk (HRs), was used to explore the association between sustainable RTW, characteristics and subgroups of sepsis patients (intensive care unit (ICU) vs. non-ICU and COVID-19 vs. non-COVID-19).

Results
Among 35.839 hospitalizations for sepsis among patients aged 18–60 years, 12.260 (34.2%) were working prior to hospitalization and included in this study. The mean age was 43.7 years. At 6 months, 1 year, and 2 years post-discharge, overall estimates showed that 58.6%, 67.5%, and 63.4%, respectively, were working. The time trends in age-standardized RTW for ICU and non-ICU sepsis patients remained stable over the study period, except the 2-year age-standardized RTW for non-ICU patients that declined by 1.51% (95% CI − 2.22 to − 0.79) per year, from 70.01% (95% CI 67.21 to 74.80) in 2010 to 57.04% (95% CI 53.81–60.28) in 2019. Characteristics associated with sustainable RTW were younger age, fewer comorbidities, and fewer acute organ dysfunctions. The probability of sustainable RTW was lower in ICU patients compared to non-ICU patients (HR 0.56; 95% CI 0.52–0.61) and higher in patients with COVID-19-related sepsis than in sepsis patients (HR 1.31; 95% CI 1.15–1.49).

Conclusion
Absence of improvement in RTW proportions over time and the low probability of sustainable RTW in sepsis patients need attention, and further research to enhance outcomes for sepsis patients is required.
The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling
Authors: Sharma Deeksha , Hager Cody G. , Shang Li , Tran Lam , Zhu Yongyou , Ma Aihui , Magnuson Brian , Lesko Matthew W. , Wicha Max S. , Burness Monika L. 
Published: November 2023

AbstractBackgroundBreast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and progression. Super-enhancers are regulators of stemness, and BET proteins, which are critical for super-enhancer function, are a potential therapeutic target. Here, we investigated the effects of BET proteins on the regulation of breast cancer stemness using the pan-BET degrader ZBC260.MethodsWe evaluated the effect of ZBC260 on CSCs in TNBC cell lines. We assessed the effect of ZBC260 on cellular viability and tumor growth and measured its effects on cancer stemness. We used RNA sequencing and stemness index to determine the global transcriptomic changes in CSCs and bulk cells and further validated our findings by qPCR, western blot, and ELISA.ResultsZBC260 potently inhibited TNBC growth both in vitro and in vivo. ZBC260 reduced stemness as measured by cell surface marker expression, ALDH activity, tumorsphere number, and stemness index while increasing differentiated cells. GSEA analysis indicated preferential downregulation of stemness-associated and inflammatory genes by ZBC260 in ALDH+CSCs.ConclusionsThe BET degrader ZBC260 is an efficient degrader of BET proteins that suppresses tumor progression and decreases CSCs through the downregulation of inflammatory genes and pathways. Our findings support the further development of BET degraders alone and in combination with other therapeutics as CSC targeting agents.
Video augmentation of the WHO cone assay to quantify mosquito behavioural responses to insecticide-treated nets
Authors: Jones Jeff , Matope Agnes , Barreaux Priscille , Gleave Katherine , Steen Keith , Ranson Hilary , McCall Philip J. , Foster Geraldine M. 
Published: November 2023

Abstract
Background
Insecticide-treated nets (ITNs) using pyrethroids have been the main vector control tools deployed in malaria endemic countries and are responsible for the dramatic reduction in African malaria cases in the early 2000s. The World Health Organization (WHO) cone test was designed to assess the rapid toxicity effects of pyrethroid exposure on mosquito vectors but has yielded no insights beyond 60-min knockdown and 24-h mortality. As dual-active-ingredient (AI) ITNs become more widespread, bioassays that can provide realistic assessment of single- and dual-treated ITNs (i.e. nets with more than one active ingredient) are urgently needed.

Methods
We present an augmentation of the cone test that enables accurate quantification of vector behavioural responses (specifically movement, spatial and temporal occupancy) to ITNs using video recording and bespoke software that uses background segmentation methods to detect spatial changes in the movement of mosquitoes within the cone. Four strains of Anopheles gambiae sensu lato (s.l.) were exposed to four ITNs (PermaNet 2.0, PermaNet 3.0, Olyset Net, Interceptor G2) and untreated nets in these modified cone tests. Life history data (post-exposure blood-feeding, blood meal weight, longevity) for individual mosquitoes were recorded.

Results
All mosquitoes responded to the presence of ITNs, spending from 1.48 to 3.67 times more time in the upper region of the cone, depending on the ITN type. Of all ITNs, PermaNet 2.0 provoked the smallest change in behavioural response. Activity in the cone influenced observed post-exposure longevity, and in resistant strains exposed to Interceptor G2, the higher the activity, the greater the risk of dying, as long as the proportion of activity at the net surface was less than 50%. All ITNs inhibited blood-feeding, and smaller blood meals were taken when mosquitoes fed.

Conclusions
The additional mosquito behaviour data obtained by using this modification to the WHO cone test provides unique insight into the innate responses of different mosquito strains on untreated nets and the entomological mode of action of ITNs, important evidence when evaluating ITN characteristics.

Graphical Abstract
The role of admixture in the rare variant contribution to inflammatory bowel disease
Authors: Astore Courtney , Sharma Shivam , Nagpal Sini ,   NIDDK IBD Genetics Consortium, Cutler David J. , Rioux John D. , Cho Judy H. , McGovern Dermot P. B. , Brant Steven R. , Kugathasan Subra , Jordan I. King , Gibson Greg 
Published: November 2023

Abstract
Background
Identification of rare variants involved in complex, polygenic diseases like Crohn’s disease (CD) has accelerated with the introduction of whole exome/genome sequencing association studies. Rare variants can be used in both diagnostic and therapeutic assessments; however, since they are likely to be restricted to specific ancestry groups, their contributions to risk assessment need to be evaluated outside the discovery population. Prior studies implied that the three known rare variants in NOD2 are absent in West African and Asian populations and only contribute in African Americans via admixture.

Methods
Whole genome sequencing (WGS) data from 3418 African American individuals, 1774 inflammatory bowel disease (IBD) cases, and 1644 controls were used to assess odds ratios and allele frequencies (AF), as well as haplotype-specific ancestral origins of European-derived CD variants discovered in a large exome-wide association study. Local and global ancestry was performed to assess the contribution of admixture to IBD contrasting European and African American cohorts.

Results
Twenty-five rare variants associated with CD in European discovery cohorts are typically five-fold lower frequency in African Americans. Correspondingly, where comparisons could be made, the rare variants were found to have a predicted four-fold reduced burden for IBD in African Americans, when compared to European individuals. Almost all of the rare CD European variants were found on European haplotypes in the African American cohort, implying that they contribute to disease risk in African Americans primarily due to recent admixture. In addition, proportion of European ancestry correlates the number of rare CD European variants each African American individual carry, as well as their polygenic risk of disease. Similar findings were observed for 23 mutations affecting 10 other common complex diseases for which the rare variants were discovered in European cohorts.

Conclusions
European-derived Crohn’s disease rare variants are even more rare in African Americans and contribute to disease risk mainly due to admixture, which needs to be accounted for when performing cross-ancestry genetic assessments.
The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
Authors: Cheng Bisheng , Li Lingfeng , Wu Yongxin , Luo Tianlong , Tang Chen , Wang Qiong , Zhou Qianghua , Wu Jilin , Lai Yiming , Zhu Dingjun , Du Tao , Huang Hai 
Published: November 2023

Abstract
Background
Prostate cancer is a leading cause of cancer-related deaths among men worldwide. Docetaxel chemotherapy has proven effective in improving overall survival in patients with castration-resistant prostate cancer (CRPC), but drug resistance remains a considerable clinical challenge.

Methods
We explored the role of Ribonucleotide reductase subunit M2 (RRM2), a gene associated with senescence, in the sensitivity of prostate cancer to docetaxel. We evaluated the RRM2 expression, docetaxel resistance, and ANXA1 expression in prostate cancer cell lines and tumour xenografts models. In addition, We assessed the impact of RRM2 knockdown, ANXA1 over-expression, and PI3K/AKT pathway inhibition on the sensitivity of prostate cancer cells to docetaxel. Furthermore, we assessed the sensitivity of prostate cancer cells to the combination treatment of COH29 and docetaxel.

Results
Our results demonstrated a positive association between RRM2 expression and docetaxel resistance in prostate cancer cell lines and tumor xenograft models. Knockdown of RRM2 increased the sensitivity of prostate cancer cells to docetaxel, suggesting its role in mediating resistance. Furthermore, we observed that RRM2 stabilizes the expression of ANXA1, which in turn activates the PI3K/AKT pathway and contributes to docetaxel resistance. Importantly, we found that the combination treatment of COH29 and docetaxel resulted in a synergistic effect, further augmenting the sensitivity of prostate cancer cells to docetaxel.

Conclusion
Our findings suggest that RRM2 regulates docetaxel resistance in prostate cancer by stabilizing ANXA1-mediated activation of the PI3K/AKT pathway. Targeting RRM2 or ANXA1 may offer a promising therapeutic strategy to overcome docetaxel resistance in prostate cancer.

Graphical Abstract
Potential ‘anti-cancer’ effects of esketamine on proliferation, apoptosis, migration and invasion in esophageal squamous carcinoma cells
Authors: Li Chao , Shi Jingpu , Wei Sisi , Jia Huiqun 
Published: November 2023

Abstract
Background
Esketamine, an N-methyl-D-aspartate receptor antagonist, is commonly used for anesthesia and analgesia clinically. It was reported to negatively regulate cell proliferation, metastasis and apoptosis in cancer cells, including lung cancer and pancreatic cancer. However, its impact on esophageal squamous cell carcinoma (ESCC) malignance and underlying mechanism remain elusive. This study was aimed to investigate the antitumor effects of esketamine on ESCC in vitro.

Methods
ESCC cell lines (KYSE-30 and KYSE-150) were cultured and treated with different concentrations (0.1, 0.2, 0.4, 0.8, 1, 2 mM) of esketamine. Their proliferation, apoptosis, migration and invasion were assessed with various assays. Furthermore, mass spectrometry-based proteomic analysis and GO/KEGG enrichment analysis were applied to characterize the differentially expressed proteins (DEPs) with or without esketamine treatment. Some key proteins identified from proteomic analysis were further validated with Western blotting and bioinformatics analysis.

Results
Esketamine significantly inhibited the proliferation, migration, invasion and promoted apoptosis of the both types of cell lines in a dose- and time-dependent manner. A total of 321 common DEPs, including 97 upregulated and 224 downregulated proteins, were found with HPLC–MS analyses. GO/KEGG enrichment analysis suggested that esketamine affected cell population proliferation, GTPase activity and Apelin signaling pathway. The ERCC6L, AHR and KIF2C protein expression was significantly downregulated in these ESCC cells treated with esketamine compared to the controls and their changes were associated with the suppressive effects of esketamine on ESCC through bioinformatics analysis.

Conclusions
Our work demonstrated that esketamine has potential anti-ESCC properties in vitro but subjected to further in vivo and clinical study.
Damage and Deterioration Mechanism of Coal Gangue Mixed Pumice Aggregate Concrete Under Freeze–Thaw Cycles
Authors: Li Wen , Wang Hailong , Zhang Wenyan 
Published: November 2023

AbstractThe world is facing the problem of depletion of natural sand and gravel resources, and a large amount of coal gangue solid waste is produced in Inner Mongolia, China, which has low utilization rate and causes ecological pollution. In order to improve the gangue in the mining infrastructure construction of a wide range of application prospects, the use of coal gangue as the coarse aggregate of pumice concrete is of great significance. Inner Mongolia is a cold region, and gangue mixed aggregate concrete (MFC) will certainly face the damage caused by freeze–thaw cycles. Therefore, design gangue by different volume replacement rate (0%, 20%, 40%, 60%, 80%,
100%) to replace pumice coarse aggregate. The results show that with the increase of gangue substitution rate, the mass loss rate, relative dynamic elastic modulus, and peak stress of MFC decrease, but the trend of peak strain increases. It is mainly attributed to the less Al2O3 and SiO2 content of gangue, which makes the MFC hydration products decrease with the increase of substitution rate and more original microcracks and pores in the specimens. In addition, the damage model of MFC was established by using Weibull statistical distribution theory and the principle of LEMAITRE equivalent effect variation assumption, and the damage evolution characteristics were explored by combining the experimental results. It can provide the theoretical basis for the application of MFC in cold regions.
Digital social innovation based on Big Data Analytics for health and well-being of society
Authors: Batko Kornelia 
Published: November 2023

Abstract
Background
Any nation's health policy aims to properly care for its citizens and the society's quality of life. Since in the healthcare system, the population's health is the essential component of national wealth, health is treated as a public good and a social value. Therefore, in recent times, in addition to traditional instruments for promoting healthy lifestyles, health policy has increasingly turned to information instruments and digital technologies.

Aims
The paper aims to recognize the role of Big Data Analytics (BDA) in developing Digital Social Innovation (DSI) in the healthcare field. The proposal of the author's Individual Health Plan Platform (IHPP) solution is presented as an example of Digital Social Innovation.

Material and methods
The research is based on a critical analysis of the literature, followed by a Focus Group study aimed at determining the potential of Big Data Analytics, including especially analysis based on data from wearables, to help manage one's health and improve the society's well-being. The focus research also included verification of the research model presented in the article and evaluation of the proposed solution, the Individual Health Plan Platform, including the possibilities of its implementation as a solution to complement healthcare provided by medical facilities in Poland.

Results
The results of the focus group interviews show that analysing data from wearables and the proposed IHPP could be helpful in managing one's own health and helping to level important problems in healthcare.

Conclusion
One of the goals of this paper was to determine the role of BDAs in the development of social innovations in healthcare. From the analysis of the literature, results of the focus group study and discussion, it was concluded that Big Data Analytics has the potential to develop social innovation in healthcare.
The AI generation gap: Are Gen Z students more interested in adopting generative AI such as ChatGPT in teaching and learning than their Gen X and millennial generation teachers?
Authors: Chan Cecilia Ka Yuk , Lee Katherine K. W. 
Published: November 2023

AbstractThis study aimed to explore the experiences, perceptions, knowledge, concerns, and intentions of Generation Z (Gen Z) students with Generation X (Gen X) and Generation Y (Gen Y) teachers regarding the use of generative AI (GenAI) in higher education. A sample of students and teachers were recruited to investigate the above using a survey consisting of both open and closed questions. The findings showed that Gen Z participants were generally optimistic about the potential benefits of GenAI, including enhanced productivity, efficiency, and personalized learning, and expressed intentions to use GenAI for various educational purposes. Gen X and Gen Y teachers acknowledged the potential benefits of GenAI but expressed heightened concerns about overreliance, ethical and pedagogical implications, emphasizing the need for proper guidelines and policies to ensure responsible use of the technology. The study highlighted the importance of combining technology with traditional teaching methods to provide a more effective learning experience. Implications of the findings include the need to develop evidence-based guidelines and policies for GenAI integration, foster critical thinking and digital literacy skills among students, and promote responsible use of GenAI technologies in higher education.
A newly revised estimation of bulk densities and examination of the shape of individual Ryugu grains
Authors: Miyazaki Akiko , Yada Toru , Yogata Kasumi , Hatakeda Kentaro , Nakato Aiko , Nishimura Masahiro , Nagashima Kana , Kumagai Kazuya , Hitomi Yuya , Soejima Hiromichi , Tahara Rui , Kanemaru Rei , Nakano Arisa , Yoshitake Miwa , Iwamae Ayako , Furuya Shizuho , Tsuchiyama Akira , Tachibana Shogo , Michikami Tatsuhiro , Okada Tatsuaki , Abe Masanao , Usui Tomohiro 
Published: November 2023

AbstractThe bulk density of grains from a celestial body is a fundamental property related to its composition and structure, contributing to the understanding of its evolutionary history. In this study, we provide the bulk density of 637 grains returned from the C-type near-Earth asteroid 162173 Ryugu. This is the largest number of grains to date for the curation activity, corresponding to 38 wt.% of the total returned samples (approximately 5.4 g). Although several densities of the Ryugu grains were reported, the volume estimation of some samples showed uncertainties. Therefore, we applied a new volume estimation model calibrated by X-ray micro-computed tomography (XCT) to the Ryugu grains to more accurately estimate their bulk density. The obtained average bulk density of 637 Ryugu grains was 1.79 ± 0.31 g/cm3 (1σ variation) for weights of 0.5‒100 mg (sub-mm ‒to 10 mm) irrespective of their 3D shapes characterized by three axial length ratios, considered to be a representative of the returned samples. The bulk density distributions of the grains in Chambers A and C were statistically distinguishable, with mean values of 1.81 ± 0.30 and 1.76 ± 0.33 g/cm3 (1σ variations), respectively. Despite the small difference, bulk density may have differed by sampling site. The obtained average bulk density value of A + C samples was almost the same as that of 16 Ryugu grains estimated based on CT scanned data, and was consistent with the densities of CI chondrites (1.57–1.91 g/cm3). The axial ratios of the grains in Chambers A and C were similar and those of the 724 returned samples and the flying particles ejected during the sampling operations were also similar, suggesting that relatively small Ryugu materials (mm‒cm in size) are similar in shape. The minor difference between the Rygu grains and flying particles could be attributed to events such as scraping during sampling operations and transportation.
Graphical Abstract
A rare case of localized peliosis hepatis during adjuvant chemotherapy including oxaliplatin mimicking a liver metastasis of colon cancer
Authors: Dejima Akira , Seyama Yasuji , Nakano Daisuke , Takao Misato , Natsume Soichiro , Takao Mikiya , Nakamori Sakiko , Kanai Tatsuya , Horiguchi Shinichiro , Kawai Kazushige 
Published: November 2023

Abstract
Background
Oxaliplatin-based regimens are commonly used as adjuvant chemotherapy following surgery for colorectal cancer. Adverse events associated with oxaliplatin include blue liver, which is caused by sinusoidal dilation and diffuse peliosis hepatis. We report herein a case of localized peliosis hepatis closely resembling a metastatic liver tumor.

Case presentation
The patient, a 50-year-old male, underwent a robotically assisted colectomy for rectosigmoid colon cancer, which was discovered when hematochezia occurred. The patient received a diagnosis of pStage IIIb and was treated with four courses of CAPOX as adjuvant chemotherapy starting at postoperative month 1. At postoperative month 4, contrast-enhanced computed tomography (CT) of the abdomen revealed a 20-mm, low-density area with heterogeneous internal structure in S6/7 of the liver. Abdominal ultrasound and gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI) findings led to a diagnosis of metastatic liver tumor, for which a laparoscopic partial hepatectomy was performed. The resected lesion was a dark reddish-brown nodule with indistinct margins that appeared to be continuous with the surrounding area. Histopathological analysis revealed severe, localized dilatation of the sinusoids and congestion consistent with the gross nodule. Based on these findings, localized peliosis hepatis associated with oxaliplatin-induced sinusoidal damage was diagnosed.

Conclusions
Localized peliosis hepatis associated with oxaliplatin use can be difficult to distinguish from a metastatic liver tumor on imaging studies.