bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas
Authors: Gallardo-Gómez María , Rodríguez-Girondo Mar , Planell Núria , Moran Sebastian , Bujanda Luis , Etxart Ane , Castells Antoni , Balaguer Francesc , Jover Rodrigo , Esteller Manel , Cubiella Joaquín , Gómez-Cabrero David , De Chiara Loretta 
Published: October 2023

Abstract
Background
Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates. A blood test may improve both the adherence to screening and the selection to colonoscopy. In this study, we conducted a serum-based discovery and validation of cfDNA methylation biomarkers for CRC screening in a multicenter cohort of 433 serum samples including healthy controls, benign pathologies, advanced adenomas (AA), and CRC.

Results
First, we performed an epigenome-wide methylation analysis with the MethylationEPIC array using a sample pooling approach, followed by a robust prioritization of candidate biomarkers for the detection of advanced neoplasia (AN: AA and CRC). Then, candidate biomarkers were validated by pyrosequencing in independent individual cfDNA samples. We report GALNT9, UPF3A, WARS, and LDB2 as new noninvasive biomarkers for the early detection of AN. The combination of GALNT9/UPF3A by logistic regression discriminated AN with 78.8% sensitivity and 100% specificity, outperforming the commonly used fecal immunochemical test and the methylated SEPT9 blood test.

Conclusions
Overall, this study highlights the utility of cfDNA methylation for CRC screening. Our results suggest that the combination methylated GALNT9/UPF3A has the potential to serve as a highly specific and sensitive blood-based test for screening and early detection of CRC.
Primary hydatid cyst of the thyroid glands: two case reports and a review of the literature
Authors: Safarpour Mohammad Mostafa , Aminnia Shiva , Dehghanian Amirreza , Borazjani Roham , Abbassi Hamid Reza , Boland Parvaz Shahram , Paydar Shahram 
Published: October 2023

AbstractIntroductionAlthough hydatid cyst remains one of the prevalent parasitic infections in humans, hydatid cyst of the thyroid is extremely rare, even in endemic areas. Here we present two cases of thyroid hydatid cysts.Case presentationA 35 and a 50 year-old Iranian female with a positive history of animal contact were presented with a neck lump without any compressive symptoms. A physical exam revealed neck masses that elevated with swallowing. Thyroid gland ultrasonography showed cystic thyroid lesions, and fine needle aspiration (FNA) suggested a thyroid hydatic cyst. Thyroid lobectomy and isthmectomy were done for the first patient, and near-total thyroidectomy was done for the other. The pathology report confirmed the diagnosis of a hydatid cyst. None of the patients had hydatid cysts in other sites. Patients were discharged without an antiparasitic drug, and no recurrence was detected at the six-month follow-up.ConclusionIt is necessary to consider hydatid cysts in the differential diagnosis of cystic lesions of the thyroid gland in endemic areas, especially in people with a positive history of animal contact.
Evaluation of a preservative-free, cross-linked sodium hyaluronate-based solution, Lacri +®, in dogs with dry eye: a pilot trial
Authors: Gard Carole , Cassagnes Charles , Muller Sarah , Navarro Christelle , Jahier Bruno 
Published: October 2023

Abstract
Background
The purpose of this pilot trial was to evaluate the efficacy and benefits of a preservative-free cross-linked sodium hyaluronate solution (Lacri +®, MP Labo, France) in 19 privately-owned dogs with dry eye. The animals were administered 2 drops of the tested product in each affected eye, twice a day (BID) for 30 days. Improvement in the global ocular clinical score (sum of the individual scores for conjunctivitis, ocular discharge, eye irritation, and corneal opacity/pigmentation/vascularization, each rated from 0 to 3) was defined as the primary outcome. Besides an improvement in each individual ocular score, tear film quality (Tear Break Up Time, TBUT), dogs’ and owners’ quality of life (QoL), as well as an increase in tear production (Schirmer Tear Test-1, STT1), were considered secondary outcomes. These criteria were assessed on D0, D0 + 15 days, and D0 + 30 days. Finally, a qualitative evaluation of clinical improvement was requested from the owners on D0 + 2, + 15 & + 30 days and from the investigators during the follow-up.

Results
The global clinical ocular score as well as the individual conjunctival and irritation scores improved significantly (p < 0.0001) during the pilot trial. The average reduction of the global score reached 30% on D0 + 15 days and 55% on D0 + 30 days compared to D0. Ocular discharge was significantly lower (p = 0.0002) on D0 + 30 days compared to baseline; however corneal opacity did not show any significant changes from D0 to the end of the follow-up period. The quantitative tear production was increased at D + 30 (p < 0.0001), with a significant improvement as soon as 2 weeks in, with around 30% and 60% of dogs presenting an STT1 value above 10 on D0 + 15 days and on D0 + 30 days, respectively. The QoL score was significantly improved compared to D0 at all time points (p < 0.0001). After 2 days of treatment, 39% of the owners rated the efficacy as “good”. The efficacy of the tested product was considered “Good” or “Very Good” by the investigators in 78% and 93% of the cases, on D0 + 15 days and D0 + 30 days, respectively. The tolerance of this preservative-free formulation was good, with only rare and transient minor local reactions, realated to administration rather than the product itself.
Urban localization using robust filtering at multiple linearization points
Authors: Gupta Shubh , Mohanty Adyasha , Gao Grace 
Published: October 2023

AbstractWe propose a robust Bayesian filtering framework for state and multi-modal uncertainty estimation in urban settings by fusing diverse sensor measurements. Our framework addresses multi-modal uncertainty from various error sources by tracking a separate probability distribution for linearization points corresponding to dynamics, measurements, and cost functions. Multiple parallel robust Extended Kalman filters (R-EKF) leverage these linearization points to characterize the state probability distribution. Employing Rao–Blackwellization, we combine the linearization point distribution with the state distribution, resulting in a unified, efficient, and outlier-resistant Bayesian filter that captures multi-modal uncertainty. Furthermore, we introduce a gradient descent-based optimization method to refine the filter parameters using available data. Evaluating our filter on real-world data from a multi-sensor setup comprising camera, Global Navigation Satellite System (GNSS), and Attitude and Heading Reference System (AHRS) demonstrates improved performance in bounding position errors based on uncertainty, while maintaining competitive accuracy and comparable computation to existing methods. Our results suggest that our framework is a promising direction for safe and reliable localization in urban environments.
Reimagining large river management using the Resist–Accept–Direct (RAD) framework in the Upper Mississippi River
Authors: Ward Nicole K. , Lynch Abigail J. , Beever Erik A. , Booker Joshua , Bouska Kristen L. , Embke Holly , Houser Jeffrey N. , Kocik John F. , Kocik Joshua , Lawrence David J. , Lemon Mary Grace , Limpinsel Doug , Magee Madeline R. , Maitland Bryan M. , McKenna Owen , Meier Andrew , Morton John M. , Muehlbauer Jeffrey D. , Newman Robert , Oliver Devon C. , Rantala Heidi M. , Sass Greg G. , Shultz Aaron , Thompson Laura M. , Wilkening Jennifer L. 
Published: October 2023

Abstract
Background
Large-river decision-makers are charged with maintaining diverse ecosystem services through unprecedented social-ecological transformations as climate change and other global stressors intensify. The interconnected, dendritic habitats of rivers, which often demarcate jurisdictional boundaries, generate complex management challenges. Here, we explore how the Resist–Accept–Direct (RAD) framework may enhance large-river management by promoting coordinated and deliberate responses to social-ecological trajectories of change. The RAD framework identifies the full decision space of potential management approaches, wherein managers may resist change to maintain historical conditions, accept change toward different conditions, or direct change to a specified future with novel conditions. In the Upper Mississippi River System, managers are facing social-ecological transformations from more frequent and extreme high-water events. We illustrate how RAD-informed basin-, reach-, and site-scale decisions could: (1) provide cross-spatial scale framing; (2) open the entire decision space of potential management approaches; and (3) enhance coordinated inter-jurisdictional management in response to the trajectory of the Upper Mississippi River hydrograph.

Results
The RAD framework helps identify plausible long-term trajectories in different reaches (or subbasins) of the river and how the associated social-ecological transformations could be managed by altering site-scale conditions. Strategic reach-scale objectives may reprioritize how, where, and when site conditions could be altered to contribute to the basin goal, given the basin’s plausible trajectories of change (e.g., by coordinating action across sites to alter habitat connectivity, diversity, and redundancy in the river mosaic).

Conclusions
When faced with long-term systemic transformations (e.g., > 50 years), the RAD framework helps explicitly consider whether or when the basin vision or goals may no longer be achievable, and direct options may open yet unconsidered potential for the basin. Embedding the RAD framework in hierarchical decision-making clarifies that the selection of actions in space and time should be derived from basin-wide goals and reach-scale objectives to ensure that site-scale actions contribute effectively to the larger river habitat mosaic. Embedding the RAD framework in large-river decisions can provide the necessary conduit to link flexibility and innovation at the site scale with stability at larger scales for adaptive governance of changing social-ecological systems.
Effect of antibiotic prophylaxis in the prognosis of Post-neurosurgical meningitis patients
Authors: Zheng Guanghui , Shi Yijun , Sun Jialu , Wang Siqi , Li Xiang , Lv Hong , Zhang Guojun 
Published: October 2023

Abstract
Aims
To evaluate the effect of antibiotic prophylaxis(AP) in the prognosis of Post-neurosurgical meningitis(PNM) patients.

Methods
A cohort analysis was performed using the clinical database in Beijing Tiantan Hospital and Capital Medical University. Data were collected on patients with the diagnosis of PNM (n = 3931) during 2012.01 to 2022.04. The microbial distribution, types of AP, and 42 and 90 days survival analysis of AP patients were evaluated using probable statistical methods. Independent risk factors for mortality were established by constructing a logistic regression analysis.

Result
A total of 1,190 patients were included in this study, Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus occupied the highest proportion. Of them, 929 cases received AP, cefuroxime and ceftriaxone are the most frequent used antibiotics. In addition, We found that PNM patients without AP significantly increased the 42 days and 90 days all-cause mortality rates. The use of different levels of AP did not improve patient outcomes, and ICU admission and assisted mechanical ventilation (AMV) were identified as independent mortality risk factors for PNM patient received AP.

Conclusions
AP plays an important role in the prognosis of PNM patients and has a significant function in improving prognosis. The prevention of PNM with antibiotics prior to neurosurgery should be emphasized in clinical practice, and appropriate selection of antibiotics is necessary to prevent the occurrence of infection and inhibit the emergence of antibiotic-resistant bacteria.
Promoting adult health: the neurophysiological benefits of watering plants and engaging in mental tasks within designed environments
Authors: Hassan Ahmad , Deshun Zhang 
Published: October 2023

Abstract
Background
Indoor, sedentary lifestyles have disconnected individuals from nature, necessitating interventions to reestablish this bond. Performing horticultural activities, such as watering houseplants, offers a potential solution. This study sought to determine how participating in horticulture activities affected adults’ cognitive and emotional moods.

Methods
We compared the benefits of watering houseplants (a gardening task) to those of standing while performing a computer task (a mental task). Chinese participants, aged 20 to 21 years, were recruited; their physiological and psychological reactions were measured using electroencephalograms, blood pressure assessments, and psychological assessments.

Results
Fifty participants were included. Watering indoor plants significantly reduced blood pressure, without affecting pulse rate. During the plant watering task as opposed to the mental activity, more dramatic different patterns of very high alpha and beta brainwave activity were identified. Participants reported increased happiness following gardening activities.

Conclusions
The findings of this study highlight the substantial relaxation benefits, both mental and physical, associated with the simple act of watering indoor plants.
Long-term prognostic significance of gasping in out-of-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation: a post hoc analysis of a multi-center prospective cohort study
Authors: Nara Satoshi , Bunya Naofumi , Ohnishi Hirofumi , Sawamoto Keigo , Uemura Shuji , Kokubu Nobuaki , Hase Mamoru , Narimatsu Eichi , Asai Yasufumi , Tahara Yoshio , Atsumi Takahiro , Nagao Ken , Morimura Naoto , Sakamoto Tetsuya ,   SAVE-J Study Group
Published: October 2023

Abstract
Background
Gasping during resuscitation has been reported as a favorable factor for out-of-hospital cardiac arrest. We examined whether gasping during resuscitation is independently associated with favorable neurological outcomes in patients with refractory ventricular fibrillation or pulseless ventricular tachycardia (VF/pVT) undergoing extracorporeal cardiopulmonary resuscitation ECPR.

Methods
Data from a 2014 study on advanced cardiac life support for ventricular fibrillation with extracorporeal circulation in Japan (SAVE-J), which examined the efficacy of ECPR for refractory VF/pVT, were analyzed. The primary endpoint was survival with a 6-month favorable neurological outcome in patients who underwent ECPR with or without gasping during resuscitation. Multivariate logistic regression analysis was performed to evaluate the association between gasping and outcomes.

Results
Of the 454 patients included in the SAVE-J study, data from 212 patients were analyzed in this study after excluding those with missing information and those who did not undergo ECPR. Gasping has been observed in 47 patients during resuscitation; 11 (23.4%) had a favorable neurological outcome at 6 months. Multivariate logistic regression analysis showed that gasping during resuscitation was independently associated with a favorable neurological outcome (odds ratio [OR], 10.58 [95% confidence interval (CI) 3.22–34.74]). The adjusted OR for gasping during emergency medical service transport and on arrival at the hospital was 27.44 (95% CI 5.65–133.41).

Conclusions
Gasping during resuscitation is a favorable factor in patients with refractory VF/pVT. Patients with refractory VF/pVT with continuously preserved gasping during EMS transportation to the hospital are expected to have more favorable outcomes.
Assessing neutrophil-derived ROS production at the bedside: a potential prognostic tool in severe COVID-19 cases
Authors: Dündar Nazlıhan Boyacı , Sarphie David , Yüce Kenan , Gaygısız Ümmügülsüm , Kaskatı O. Tolga , Türkoğlu Melda , Bıkmaz Gülbin Aygencel , Karabıyık Lale , Çağlar Kayhan , Bozdayı Gülendam , Mian Rubina , Moss Paul , İlhan Mustafa Necmi 
Published: October 2023

Abstract
Purpose
A prompt and effective immune response is required for clearance of pathogens but exaggerated states of inflammation can cause extensive collateral damage to the host. We have previously used a rapid near-patient assay that measures the functional capacity of neutrophils to produce reactive oxygen species (ROS) to show that values are elevated in patients with severe COVID-19 or sepsis. Here, we assess the utility of longitudinal ROS measurements to monitor and predict mortality outcome for patients with COVID-19 infection being treated in an ICU setting.

Methods
We used the Leukocyte ImmunoTest™ (LIT™) to quantify neutrophil ROS release using a small volume (10 µL) of capillary blood in a portable, rapid (10-min) format.

Results
ROS values (LIT score) and ROS levels assessed in relation to neutrophil count (LIT/N) were both markedly elevated in the patient group. Furthermore, these correlated strongly with peripheral neutrophil count and CRP value. Serial measurement of neutrophil or CRP values were not able to reliably predict mortality within the study. In contrast, LIT and LIT/N values started to decline at 7 and 5 days, respectively, in patients who survived ICU admission and this increment increased further thereafter.

Conclusions
This study raises the possibility of LIT and LIT/N to be used as a predictive clinical tool for patients with severe COVID-19 and argues for its assessment to inform on prognosis, and potentially guide treatment pathways, in other disorders associated with neutrophil activation.

Take-home message
A longitudinal study of 44 severe COVID-19 patients in the ICU of a leading teaching hospital has demonstrated the prognostic potential of a rapid bedside assay of neutrophil-derived reactive oxygen species (ROS). Assessment of changes in ROS production, as measured using the Leukocyte ImmunoTest™, shows that ROS production generally declined back to normal levels for patients who survived, but remained elevated for those patients who did not survive.
Strongyloides hyperinfection syndrome precipitated by immunosuppressive therapy for rheumatoid arthritis and COVID-19 pneumonia
Authors: Hamze Hasan , Tai Teresa , Harris David 
Published: October 2023

AbstractThe COVID-19 pandemic has posed clinical and public health challenges worldwide. The use of corticosteroids has become an evidence-based practice to reduce the hyperinflammatory process involved in severe COVID-19 disease. However, this can result in the reactivation of parasitic infestations, even with a short course. We report the case of a 64-year-old Cuban born patient who passed away from S. stercoralis hyperinfection syndrome following treatment with dexamethasone for severe COVID-19 disease on a background of prolonged immunosuppression for rheumatoid arthritis. Clinicians should be aware of the risk of strongyloidiasis as a complication of the treatment for severe COVID-19 and other immunosuppressive therapies. We recommend empiric Strongyloides treatment for those who are from, or who have accumulated risk by travelling to endemic areas, and are being treated with corticosteroids for severe COVID-19 disease.
Metric and morphological features of the ear in sex classification
Authors: Sezgin Nurdan , Ersoy Gökhan 
Published: October 2023

Abstract
Background
The human face can reveal a great deal about a person’s identity. Age, sex, and ethnicity differences can be recognized, classified, and analyzed using facial features, which give a scientific basis for personal identification and recognition. Sex, like age and ethnicity, has a significant influence on outer ear morphology. The shape and size of the auricle, which is one of the defining features of the face, are affected by age, sex, and ethnicity. Variations in the outer ear are known to be sufficient for identification in a forensic case and can help in determining whether the suspect is guilty or not. The aim of this research is to determine whether such metric and morphological features of the ear can be used to estimate sex and how dimorphic they are. After ear measurements with ImageJ 1.52a program, statistical data was recorded and analyzed in SPSS.

Results
This study, which analyzed 350 people’s facial images, provides significant information for forensic applications. Among the analyzed ear morphology data, the helix and ear lobe form showed sex differences. Except for the T-PCC distance, all measurements differed significantly between sexes.

Conclusions
Model 1 has the greatest accuracy rate (88%) among the models created for sex estimation. Sex estimation can be performed as an effective method when the morphological and metric parameters of the ear are analyzed together.
Fabrication, design, and in vivo investigation of mesoporous silica-based docetaxel trihydrate nanoparticles for colonic drug delivery
Authors: Majumdar Subhabrota , Mondal Mohini , Bose Anirbandeep , Kar Ayan Kumar , Mazumder Rana 
Published: October 2023

Abstract
Background
Mesoporous silica-loaded docetaxel trihydrate nanoparticles are the potential to target drug delivery toward a specific region with high stability and predictable release at the target region. They have large surface areas and mesoporous structures with large pore volumes, leading to high bioavailability and therapeutic efficacy at the disease site. This study demonstrates how nanoparticles can be prepared using an emulsion technique.

Results
The ratios of eudragit S100 to eudragit L100 polymers, along with phosphatidylcholine, were varied according to the response surface methodology. Differential scanning colorimetry and fluorinated transmitted infrared spectroscopy studies showed that mesoporous silica particles were successful. All formulations had average particle sizes ranging from 70.65 to 143.01 nm, with a range of zeta potential from 17.6 ± 026 to 21 ± 011. In vitro drug delivery studies were achieved for all formulations with a zeta potential of 17.6 ± 026 to 21 ± 011. As per the statistical optimization by RSM that response model for percentage drug loading (Y1) was found to be 0.0002 which is p-value < 0.05. Hence, the model is significance. Accordingly percentage drug release at 6 h. (Y2) p-value was found to be 0.0001 and percentage drug release at 10 h (Y3) p-value was found to be 0.0002, respectively. So all the models are significant. After oral administration of the docetaxel, plasma levels were measured in vivo bioavailability testing of docetaxel. Docetaxel nanosuspension had a significantly higher Cmax amount than docetaxel microsuspension (98.03 ± 23.40 ng/ml and 213.67 ± 72.21 ng/ml, respectively, with tmax 45 min). Docetaxel was more bioavailable in nanosuspension formulations, according to a bioavailability test of rats.

Conclusion
The results suggested that the mesoporous silica could be a great potential nanocarrier in colonic delivery with optimal drug content and controlled release docetaxel trihydrate.