bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of incidence of hypertension in France and associated factors: results from the CONSTANCES cohort
Authors: Cheddani Lynda , Lelong Hélène , Goldberg Marcel , Zins Marie , Blacher Jacques , Kab Sofiane 
Published: February 2025

Introduction:
Estimating hypertension incidence and improving screening in general population could enhance blood pressure control and decrease cardiometabolic risks. Identifying those likely to develop hypertension is essential. Our study focused on predicting onset hypertension and its incidence based on initial characteristics.

Methods:
We utilized data from the French prospective CONSTANCES cohort, including volunteers assessed twice over 5 years up to 31 December 2019, who were initially free from hypertension. Hypertension was defined as having a SBP at least 140 mmHg or DBP at least 90 mmHg during the second checkup or if antihypertensive medication was prescribed. We calculated annual incidence rates among subgroups and used machine learning models to identify predictors of hypertension. The impact of changes in BMI was analyzed using logistic regression.

Results:
Of the 11 112 participants (average age 47.5 ± 12 years), 1929 (17.4%) developed hypertension within an average of 5.2 years, with 383 on medication. The incidence rate was 3.4 new cases per 100 person-years, rising with age and consistently higher in men (4.3 vs. 2.8). A blood pressure (BP) threshold of 130 mmHg predicted 70% of new cases. One-point BMI reduction significantly reduced hypertension risk by 16%, regardless of initial BMI and SBP levels.

Conclusion:
The study reports a notable hypertension incidence of 3.4 new cases per 100 person-years, particularly among those with SBP over 130 mmHg, highlighting the need for regular screening. Early diagnosis and control can mitigate hypertension's adverse effects, emphasizing the crucial role of preventive measures like BMI reduction.
Atypical Autofluorescence Findings in Geographic Atrophy: The Influence of Age-Related Choroidal Atrophy
Authors: Faes Livia , Jung Jesse J. , Sorenson John , Freund K. Bailey 
Published: February 2025

Purpose:
To describe atypical fundus autofluorescence (FAF) patterns in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) with associated age-related choroidal atrophy (ARCA).

Methods:
Multimodal imaging of two cases using (pseudo-)color fundus photography, optical coherence tomography (OCT), fluorescein and indocyanine green angiography, and FAF employed with blue- and green excitation wavelengths on several devices (Spectralis, Heidelberg and (ultra-)widefield [UWF] FAF [California, Optos and EIDON, iCare]).

Results:
Two female patients, with foveal-involving GA secondary to AMD, were assessed. All eyes demonstrated concurrent features indicative of ARCA on multimodal imaging including a paucity of choroidal vasculature, reduced choroidal pigmentation, macular pigmentary changes, peripapillary atrophy, and subretinal drusenoid deposits. Clinically, progression of GA with coalescence of lobular lesions was observed. Notably, UWF FAF with green-(California) and blue excitation wavelengths (California and EIDON) revealed atypical patterns characterized by isofluorescent FAF signals (indistinguishable from surrounding tissue) or hyperautofluorescent GA lesions. In these cases, blue excitation wavelengths were more effective than green light for delineating GA, owing to increased contrast from hypoautofluorescence related to macular pigment surrounding the lesion.

Conclusion:
In patients with GA and concomitant ARCA, atypical FAF patterns on UWF imaging complicate the accurate delineation and monitoring of GA. Atypical FAF patterns appear due to the properties of the confocal apertures and postprocessing features of UWF imaging that allow for the detection of scleral autofluorescence in patients with reduced choroidal vasculature, pigment and thickness. In patients with concomitant ARCA, multimodal imaging plays a crucial role in precisely identifying and tracking GA progression.
A rare concurrence of acute appendicitis with Meckel’s diverticulitis: a case report
Authors: Bastakoti Aashish , Khatiwada Abhikanta , Neupane Nischal , Bastakoti Roshani , Bastakoti Anish , Kc Sharada 
Published: February 2025

Background:
Meckel’s diverticulitis is the inflammation of Meckel’s diverticulum (MD), a common congenital structural abnormality of the gastrointestinal tract. The simultaneous occurrence of Meckel’s diverticulitis with acute appendicitis is extremely rare.

Case presentation:
A 17-year-old male presented with acute abdominal pain and vomiting, accompanied by tenderness in the right iliac fossa. Laboratory investigations revealed neutrophilia and an elevated leukocyte count, while ultrasound findings were consistent with acute appendicitis. The patient underwent an emergency open appendectomy, during which an inflamed appendix was removed. Incidentally, an inflamed MD was also discovered and managed conservatively.

Discussion:
Acute appendicitis and Meckel’s diverticulitis share overlapping clinical and imaging features, making preoperative diagnosis difficult, thereby making intraoperative evaluation essential. The management of Meckel’s diverticulitis varies depending on the patient’s condition and clinical judgment.

Conclusion:
Given the difficulty in preoperative diagnosis of Meckel’s diverticulitis, surgeons should routinely assess for MD during appendectomies, even when acute appendicitis is confirmed. Failing to identify and manage Meckel’s diverticulitis may lead to complications and adversely affect patient outcomes.
Biaxial testing and sensory texture evaluation of plant-based and animal deli meat
Authors: Pierre Skyler R. St. , Sibley Lauren Somersille , Tran Steven , Tran Vy , Darwin Ethan C. , Kuhl Ellen 
Published: February 2025

AbstractAnimal agriculture is one of the largest contributors to global carbon emissions. Plant-based meats offer a sustainable alternative to animal meat; yet, people are reluctant to switch their diets and spending habits, in large due to the taste and texture of plant-based meats. Deli meat is a convenient form of protein commonly used in sandwiches, yet little is known about its material or sensory properties. Here we performed biaxial testing with multiple different stretch ratios of four plant-based and four animal deli meats and fit accurate material models to the resulting stress-stretch data. Strikingly, the plant-based products, turkey, ham, deli, and prosciutto, with stiffnesses of 378 ± 15 kPa, 343 ± 62 kPa, 213 ± 25 kPa, and 113 ± 56 kPa, were more than twice as stiff as their animal counterparts, turkey, chicken, ham, and prosciutto, with 134 ± 46 kPa, 117 ± 17 kPa, 117 ± 21 kPa, and 49 ± 21 kPa. In a complementary sensory texture survey, n = 18 participants were able to correlate the physical stiffness with the sensory brittleness, with Spearman’s correlation coefficient ofρ= 0.857 andp= 0.011, but not with the sensory softness or hardness. Notably, the participants perceived all four plant-based products as less fibrous, less moist, and less meaty than the four animal products. Our study confirms the common belief that plant-based products struggle to meet the physical and sensory signature of animal deli meats. We anticipate that integrating rigorous mechanical testing, physics-based modeling, and sensory texture surveys could shape the path towards designing delicious, nutritious, and environmentally friendly meats that mimic the texture and mouthfeel of animal products and are healthy for people and for the planet. Data and code are freely available athttps://github.com/LivingMatterLab/CANN.
DifferentialO-Glc elongation on the specific EGF repeat within a ligand binding domain regulates NOTCH1 signaling
Authors: Tsukamoto Yohei , Aoki Kazuhiro , Saiki Wataru , Tsukamoto Natsumi , Kato Koki , Hosokawa Yohei , Sato Rie , Fujita Yuki , Fukazawa Kana , Kurebayashi Yuuki , Urata Yusuke , Uchiyama Sae , Wang Weiwei , Minami Akira , Takahashi Tadanobu , Tiemeyer Michael , Narimatsu Yoshiki , Okajima Tetsuya , Takeuchi Hideyuki 
Published: February 2025

AbstractThree types ofO-linked glycosylation -O-glucose,O-fucose, andO-N-acetylglucosamine - are crucial for the function of Notch receptors, which regulates critical cell fate determination processes in a wide variety of contexts.O-Glucose glycans are added to serine residues located between the first and second conserved cysteines within the epidermal growth factor (EGF) -like repeats in the Notch extracellular domain. Previously,O-glucose glycans were shown to be extended to a trisaccharide structure with two xyloses via an α1-3 linkage. Our recent studies, however, indicated that theO-glucose glycan on NOTCH1 EGF10 can be extended by hexose and Neu5Ac. Here, we demonstrated that this hexose- and Neu5Ac-extended glycan has a 3’-sialyllactose-like structure synthesized by specific members of two isoenzyme families, B4GALT1 and ST3GAL4. Using mass spectrometry, we identified this modification exclusively on NOTCH1 EGF10 and NOTCH3 EGF9 (equivalent to NOTCH1 EGF10), with no detection in any other EGF domains in NOTCH1-3. Sequence comparison and mutagenesis experiments identified one amino acid at position -2 of the fourth cysteine in the EGF domain as crucial for the galactose elongation ofO-glucose glycans. We further demonstrated that this site-specific elongation ofO-glucose on NOTCH1 EGF10 significantly impact ligand binding and signal transduction of NOTCH1. Our findings contribute to the understanding of the intricate regulatory mechanisms of Notch receptor function mediated by distinct positions and structures ofO-glycans.Significance StatementNotch, a signaling receptor critical for development, differentiation, and homeostasis in multicellular organisms, undergoes multiple post-translational glycan modifications to regulate its function. WhileO-glucose glycan elongation by xylose was previously known, we identified anO-glucose glycan extended by galactose and Neu5Ac on specific epidermal growth factor (EGF) -like repeats of certain Notch paralogs, NOTCH1 and NOTCH3. As far as we know, this structure has not been reported on any other proteins. We identify the enzymes involved in the biosynthesis of this glycan and demonstrate that modifications at a specific site on Notch direct receptor functions, including ligand binding and Notch signaling.
Leveraging artificial Intelligence and online psychotherapy to achieve efficient and coordinated services within a healthcare setting: A quality improvement initiative
Authors: Stephenson Callum , Eadie Jazmin , Holmes Christina , Asadpour Kimia , Gutierrez Gilmar , Kumar Anchan , Jagayat Jasleen , Patel Charmy , Sajid Saad , Knyahnytskyi Oleksandr , Yang Megan , Reshetukha Taras , Moi Christina , Barrett Tricia , Shirazi Amirhossein , Verter Vedat , Soares Claudio , Omrani Mohsen , Alavi Nazanin 
Published: February 2025

AbstractObjectivesThis study aimed to implement an artificial intelligence-assisted psychiatric triage program, assessing its impact on efficiency and resource optimization.MethodsThis quality improvement initiative recruited patients on the waitlist for psychiatric evaluation at an outpatient hospital. Participants (n=101) completed a digital triage module that used natural language processing and machine learning to recommend a care intensity level and a disorder-specific digital psychotherapy program. A psychiatrist also assessed the same information and the decisions for care intensity and psychotherapy programs were compared with the artificial intelligence recommendations.ResultsThe overall wait time to receive care decreased by 71.43% due to this initiative. Additionally, participants received psychological care within three weeks after completing the triage module. In 71.29% of the cases, the artificial intelligence-assisted triage program and the psychiatrist suggested the same treatment intensity and psychotherapy program. Additionally, 63.29% of participants allocated to lower-intensity treatment plans by the AI-assisted triage program did not require psychiatric consultation later.ConclusionsUsing artificial intelligence to expedite psychiatric triaging is a promising solution to address long wait times for mental health care. With future accuracy refinements, this could be a valuable tool to implement in hospital settings to assist care teams and improve mental health care. This could result in increased care capacity and improved workflow and decision-making.
Respiratory Tract Pathogen Detection in Children: Clinical Practice and Considerations of mNGS and tNGS Technologies
Authors: Dujin Wang , Chuanhua Zhan , Hao Yang , Zhongliang Zhu , Yichun Zou 
Published: February 2025

AbstractObjectiveThis study aims to evaluate the efficacy of metagenomic next-generation sequencing (mNGS) and targeted next-generation sequencing (tNGS) technologies in detecting respiratory tract pathogens in hospitalized children.MethodsWe selected 1275 children hospitalized for respiratory tract infections from March to November 2024 as the study subjects. Based on clinical needs, mNGS/tNGS testing was conducted on these children, including 1225 oropharyngeal swab samples and 50 bronchoalveolar lavage fluid samples. Additionally, traditional microbial culture methods were used for testing in 574 children.ResultsThe study revealed that children aged 3 to 6 were the primary population affected by respiratory tract infections, accounting for 37.65% of the cases, with 25.1% of them having lower respiratory tract infections. Bacterial and viral co-infections were the most common infection patterns in both oropharyngeal swab and bronchoalveolar lavage fluid samples, with positive rates of 55.02% and 46%, respectively. In bronchoalveolar lavage fluid samples, Mycoplasma pneumoniae had the highest infection rate at 41.67%, followed by Streptococcus pneumoniae and Haemophilus influenzae. The highest detection rate in bronchoalveolar lavage fluid samples was for human adenovirus at 28.3%, followed by rhinovirus and human parainfluenza virus type 3. In oropharyngeal swab samples, Streptococcus pneumoniae had the highest detection rate, followed by Staphylococcus aureus and Haemophilus influenzae. Rhinovirus had the highest detection rate in oropharyngeal swab samples at 25.07%, followed by cytomegalovirus (CMV) and human adenovirus. There was a high consistency between mNGS/tNGS and traditional culture methods in bacterial detection, with the top three being Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenzae. The serum IL-6 concentration in patients with single bacterial infections was higher than in those with single viral infections; the serum IL-6 in patients with bacterial and viral co-infections was higher than in those with single infections, with statistically significant differences. There were statistically significant differences in serum PCT concentration between patients with single bacterial infections and single viral infections, but no significant differences between patients with single bacterial infections and those with bacterial and viral co-infections. The most frequently detected resistance genes included CTX-M-108, NDM-6, OXA-163, tetM, KPC-2, and mecA.ConclusionmNGS/tNGS technology significantly improved the detection rate of respiratory tract pathogens in children, showing clear advantages over traditional bacterial culture methods in terms of timeliness, accuracy, and coverage of pathogen detection, providing strong technical support for early diagnosis and intervention of respiratory infections in children.
Green HRM and employer branding: corporate environmental sustainability and organizational safety climate mediating role and moderating role of job experience
Authors: Yasin Raheel , Bataineh Mohammad Saleh , Atif Muhammad , Hossain Md Tareq Bin 
Published: February 2025

PurposeThis study purposes a model based on competitive advantage theory, social identity theory and signaling theory that explores the relationship between GHRM and employer branding mediated by corporate environmental sustainability and organizational safety climate and employees experience as a moderator.Design/methodology/approachData were gathered using a survey questionnaire from 329 employees working in this sector. Structural Equational Modeling was employed for data analysis through Smart PLS.FindingsResults confirm that GHRM has a positive influence on corporate environmental sustainability and corporate environmental sustainability has a positive influence on organizational safety climate. Further, the results confirm that the organizational safety climate has a positive influence on employer branding. The results of partial least squares multi-group analysis show that difference between job experience influences employer branding. The results also lend support to the mediating effects of corporate environmental sustainability between GHRM and organizational safety climate, and the mediating effect of organizational safety climate between GHRM and employer branding.Practical implicationsThe findings of the study guide policymakers and management of the textile industry to emphasize GHRM in order to make a working climate clean and safe. This working environment will be their competitive edge and a source of their organization branding.Originality/valueHR literature has largely overlooked the physical work environment, instead focusing on psychological safety, for example (job stress, emotional exhaustion). This study presents a model demonstrating that a green work environment, fostered through GHRM practices enhances employer branding.
Digital infrastructure and the cost of debt: evidence from “BroadBand China” policy
Authors: Jiang Yan , Lv Dayong , Hao Suyu , Wei Xiaokun , Wu Youyi 
Published: February 2025

PurposeThis paper explores the linkage of digital infrastructure to the cost of debt.Design/methodology/approachThis study uses the implementation of the “Broadband China” policy that improves digital infrastructure as an exogenous shock and exploits the difference-in-differences method (DID).FindingsEmpirical analyses show that digital infrastructure leads to increased firms’ borrowing costs, which is robust to several robustness checks. In addition, we find that this unfavourable effect can be attributed to intensified market competition led by digital infrastructure construction. Cross-sectional analysis shows that this effect is greater for non-SOEs and smaller firms. Finally, we offer additional evidence of the unfavourable effect by showing that digital infrastructure construction leads to decreased fundamentals.Originality/valueOur paper unveils how digital infrastructure construction affects firms’ business strategy in using private debts and extends the determinants of firms’ borrowing costs.
Kickstarter-driven crowdfunding: advancing sustainable innovation and mindful consumption in environmental entrepreneurship
Authors: Eizaguirre Maria , Gómez-Olmedo Ana M. , Kallmuenzer Andreas 
Published: February 2025

PurposeThis study explores how environmental crowdfunding initiatives on Kickstarter promote mindful consumption types—acquisitive, repetitive and aspirational temperance—by examining their alignment with sustainable innovation and circular economy principles. The aim is to identify project attributes that resonate with backers and encourage the adoption of sustainable practices.Design/methodology/approachUsing thematic content analysis, the study analyses project descriptions of successful Kickstarter campaigns in the environmental category. It identifies thematic patterns and distinctions among mindful consumption types and explores their relationship with crowdfunding success.FindingsStudy results reveal that financial success alone does not ensure alignment with mindful consumption principles. Key insights highlight differences in thematic priorities across mindful consumption types: acquisitive temperance emphasizes functional benefits; repetitive temperance focuses on self-reliance and renewable energy; aspirational temperance centres on creativity and community building. These variations reflect the current stage of environmental entrepreneurship and reveal a gap for achieving disruptive sustainability models.Originality/valueThis research contributes a novel framework for understanding how crowdfunding platforms can facilitate shifts towards mindful consumption by identifying specific project attributes and themes that resonate with different consumption temperance. Insights offer practical guidance for entrepreneurs and policymakers aiming to promote systemic sustainability through crowdfunding.
Shaping supply chain circularity trajectory: the role of path dependence
Authors: Silva Minelle E. , Pereira Susana Carla Farias , Sehnem Simone 
Published: February 2025

PurposeThis study aimed to understand how path dependence affects the supply chain (SC) circularity trajectory in a food cooperative SC.Design/methodology/approachTo elaborate on path dependence theory, we conducted a single case study of a cooperative SC using data gathered from four years of sustainability reports and semi-structured interviews with multiple respondents to allow for triangulation.FindingsWe found that the cooperative SC circularity trajectory examined was affected by path dependence, including path formation and context. Path formation is based on cooperativism principles (e.g. democratic control), while context is linked to circular actions adopted in this community-based configuration. For instance, the management of packaging and waste disposal are circular actions continuously learnt because of two lock-ins and specific capabilities developed in the food cooperative SC circularity trajectory.Practical implicationsRecognising the event sequencing of circular actions will help managers adopt circular economy (CE) principles and boost their SC circularity trajectories.Originality/valueUnlike previous research, this study elaborated on path dependence theory to understand the SC circularity trajectory. Such a perspective emphasised limitations in the rationale of linear performance and added new insights into the further introduction of the circular performance journey towards CE transition.
Digital marketing process enhancement in an online store utilising a combination of design of experiments and lean six sigma
Authors: McDermott Olivia , Tansha Julien Swana , Trubetskaya Anna , Rosa Angelo , Moran Rachel 
Published: February 2025

Purpose
This research aims to enhance digital marketing processes by using design of experiments in safelist mailers and traffic exchange websites.

Design/methodology/approach
The research applies design of experiments to improve an online digital marketing website.

Findings
The findings show that design of experiments can help improve digital marketing quality by generating more interactions with safelist mailers and traffic exchange websites, reducing time spent in the marketing process, allocating the appropriate amount of credits to significant websites and avoiding product price increases.

Research limitations/implications
This research aims to increase awareness of the impact and applicability of design of experiments to digital marketing and demonstrates the application of design of experiments in any digital marketing process, including safelist mailers and traffic exchange websites.

Originality/value
To the best of the authors’ knowledge, this is the first study applying design of experiments within online marketing. This study can be leveraged by academics and marketing functions to demonstrate the benefits of design of experiments to the marketing function to improve process efficiency and resource utilisation.