bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between hemoglobin and V˙O2max: A systematic review and meta-analysis
Authors: Webb Kevin L. , Gorman Ellen K. , Morkeberg Olaf H. , Klassen Stephen A. , Regimbal Riley J. , Wiggins Chad C. , Joyner Michael J. , Hammer Shane M. , Senefeld Jonathon W. 
Published: October 2023

ObjectiveThere is widespread agreement about the key role of hemoglobin for oxygen transport. Both observational and interventional studies have examined the relationship between hemoglobin levels and maximal oxygen uptake (V˙O2max) in humans. However, there exists considerable variability in the scientific literature regarding the potential relationship between hemoglobin andV˙O2max. Thus, we aimed to provide a comprehensive analysis of the diverse literature and examine the relationship between hemoglobin levels (hemoglobin concentration and mass) andV˙O2max(absolute and relativeV˙O2max) among both observational and interventional studies.MethodsA systematic search was performed on December 6th, 2021. The study procedures and reporting of findings followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Article selection and data abstraction were performed in duplicate by two independent reviewers. Primary outcomes were hemoglobin levels andV˙O2maxvalues (absolute and relative). For observational studies, meta-regression models were performed to examine the relationship between hemoglobin levels andV˙O2maxvalues. For interventional studies, meta-analysis models were performed to determine the change inV˙O2maxvalues (standard paired difference) associated with interventions designed to modify hemoglobin levels orV˙O2max. Meta-regression models were then performed to determine the relationship between a change in hemoglobin levels and the change inV˙O2maxvalues.ResultsData from 384 studies (226 observational studies and 158 interventional studies) were examined. For observational data, there was a positive association between absoluteV˙O2maxand hemoglobin levels (hemoglobin concentration, hemoglobin mass, and hematocrit (P<0.001 for all)). Prespecified subgroup analyses demonstrated no apparent sex-related differences among these relationships. For interventional data, there was a positive association between the change of absoluteV˙O2max(standard paired difference) and the change in hemoglobin levels (hemoglobin concentration (P<0.0001) and hemoglobin mass (P= 0.006)).ConclusionThese findings suggest thatV˙O2maxvalues are closely associated with hemoglobin levels among both observational and interventional studies. Although our findings suggest a lack of sex differences in these relationships, there were limited studies incorporating females or stratifying results by biological sex.
Assessing strength properties of stabilized soils using dynamic cone penetrometer test
Authors: Elias Hawraa Hadi , Shaban Alaa M. , Almuhanna Raid R. 
Published: October 2023

Abstract
The subgrade soil layer is the most essential part of the pavement system. Many pavement failures can be associated with subgrade weak strength and stiffness qualities. Therefore, it is necessary to strengthen this layer before building the other pavement layers. One of the essential methods utilized to enhance the engineering characteristics of this layer is soil stabilization. Stabilization methods are many and varied, but chemical and mechanical stabilization are the most common. This research aims to evaluate the strength of stabilized soils by using a dynamic cone penetration (DCP) test. To achieve this aim, subgrade soil was provided from a roadway project in Kerbala city and stabilized with 2.5 and 5% of Portland cement by weight of the dry soil. Then, the cemented subgrade soil was reinforced with 6 and 12 mm of polypropylene discrete fiber. The fiber was added to the soil with the following contents: 0.5, 1, and 2%. The characteristics of stabilized soils were evaluated by determining three parameters: dynamic cone penetration index (DCPI), in-situ California bearing ratio (CBR), and bearing capacity obtained from the DCP test. The results showed that when Portland cement was increased from 0 to 2.5% and then to 5% by weight of the dry soil, the DCPI value gradually decreased while increasing both CBR and bearing capacity. However, adding 6 and 12 mm fiber contents (0.5, 1, and 2) to the cement–sand mixture containing 2.5 and 5% cement led to increased DCPI and a gradual decrease in CBR and bearing capacity. Also, the results showed that the DCPI for a 12 mm fiber is lower than that for 6 mm fibers, while the CBR and bearing capacity for a 12 mm fiber are greater than those of 6 mm fibers for all ratios. Accordingly, the results of the DCP tests showed that the most significant support for the soil is obtained when the soil is stabilized using 5% cement with 12 mm of fiber by weight of dry soil.
Water, Communication, Sight, and the Location of Fortifications on the Strata Diocletiana (Syria) in Late Antiquity
Authors: Meyer Jørgen Christian , Seland Eivind Heldaas 
Published: October 2023

Abstract
The Strata Diocletiana was a military road in Late Roman Period Syria. It ran from Damascus to the Euphrates by way of Palmyra. The road was fortified and received its name during the reign of Diocletian (284–305 CE), following the Roman sack and subsequent garrisoning of Palmyra after the city’s failed revolt 272–273 CE. The Strata Diocletiana is only one of several attested routes between Palmyra and western Syria and one of two between Palmyra and Damascus. In this study, we seek to understand why this route was chosen for the new fortified road. We compare the location of Late Roman fortifications along the Strata Diocletiana to the modern distribution of water in the Syrian Desert and the theoretical least-cost paths between Palmyra and Damascus, and Palmyra and the fortress of Sura on the Euphrates. The argument is made that some parts of the Roman road network in the Syrian Desert were planned in order to control major water sources along the desert rim, but that the new military road between Damascus and Palmyra in the late third century CE was constructed with the aim of monitoring and controlling access to settled regions from the desert, in addition to ease and speed of communication. The conclusions have bearings not only on our understanding of the Late Roman defence and communication system, but also on nomad-settled interaction in Late Antiquity and the use of GIS methodologies in the reconstruction of ancient communication networks.
Bioanalytical sensors using the heat-transfer method HTM and related techniques
Authors: Wagner Patrick , Bakhshi Sichani Soroush , Khorshid Mehran , Lieberzeit Peter , Losada-Pérez Patricia , Yongabi Derick 
Published: October 2023

Abstract
This review provides an overview on bio- and chemosensors based on a thermal transducer platform that monitors the thermal interface resistance R
th between a solid chip and the supernatant liquid. The R
th parameter responds in a surprisingly strong way to molecular-scale changes at the solid–liquid interface, which can be measured thermometrically, using for instance thermocouples in combination with a controllable heat source. In 2012, the effect was first observed during on-chip denaturation experiments on complementary and mismatched DNA duplexes that differ in their melting temperature. Since then, the concept is addressed as heat-transfer method, in short HTM, and numerous applications of the basic sensing principle were identified. Functionalizing the chip with bioreceptors such as molecularly imprinted polymers makes it possible to detect neurotransmitters, inflammation markers, viruses, and environmental pollutants. In combination with aptamer-type receptors, it is also possible to detect proteins at low concentrations. Changing the receptors to surface-imprinted polymers has opened up new possibilities for quantitative bacterial detection and identification in complex matrices. In receptor-free variants, HTM was successfully used to characterize lipid vesicles and eukaryotic cells (yeast strains, cancer cell lines), the latter showing spontaneous detachment under influence of the temperature gradient inherent to HTM. We will also address modifications to the original HTM technique such as M-HTM, inverted HTM, thermal wave transport analysis TWTA, and the hot-wire principle. The article concludes with an assessment of the possibilities and current limitations of the method, together with a technological forecast.
Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival
Authors: Ronayne Conor T , Jackson Thomas D , Bennett Christopher F , Perry Elizabeth A , Kantorovic Noa , Puigserver Pere 
Published: October 2023

AbstractMitochondrial diseases are a group of disorders defined by defects in oxidative phosphorylation caused by nuclear‐ or mitochondrial‐encoded gene mutations. A main cellular phenotype of mitochondrial disease mutations is redox imbalances and inflammatory signaling underlying pathogenic signatures of these patients. One method to rescue this cell death vulnerability is the inhibition of mitochondrial translation using tetracyclines. However, the mechanisms whereby tetracyclines promote cell survival are unknown. Here, we show that tetracyclines inhibit the mitochondrial ribosome and promote survival through suppression of endoplasmic reticulum (ER) stress. Tetracyclines increase mitochondrial levels of the mitoribosome quality control factor MALSU1 (Mitochondrial Assembly of Ribosomal Large Subunit 1) and promote its recruitment to the mitoribosome large subunit, where MALSU1 is necessary for tetracycline‐induced survival and suppression of ER stress. Glucose starvation induces ER stress to activate the unfolded protein response and IRE1α‐mediated cell death that is inhibited by tetracyclines. These studies establish a new interorganelle communication whereby inhibition of the mitoribosome signals to the ER to promote survival, implicating basic mechanisms of cell survival and treatment of mitochondrial diseases.
Immune–epithelial cell cross‐talk enhances antiviral responsiveness to SARS‐CoV‐2 in children
Authors: Magalhães Vladimir G , Lukassen Sören , Drechsler Maike , Loske Jennifer , Burkart Sandy S , Wüst Sandra , Jacobsen Eva‐Maria , Röhmel Jobst , Mall Marcus A , Debatin Klaus‐Michael , Eils Roland , Autenrieth Stella , Janda Aleš , Lehmann Irina , Binder Marco 
Published: October 2023

AbstractThe risk of developing severe COVID‐19 rises dramatically with age. Schoolchildren are significantly less likely than older people to die from SARS‐CoV‐2 infection, but the molecular mechanisms underlying this age‐dependence are unknown. In primary infections, innate immunity is critical due to the lack of immune memory. Children, in particular, have a significantly stronger interferon response due to a primed state of their airway epithelium. In single‐cell transcriptomes of nasal turbinates, we find increased frequencies of immune cells and stronger cytokine‐mediated interactions with epithelial cells, resulting in increased epithelial expression of viral sensors (RIG‐I, MDA5) via IRF1. In vitro, adolescent peripheral blood mononuclear cells produce more cytokines, priming A549 cells for stronger interferon responses to SARS‐CoV‐2. Taken together, our findings suggest that increased numbers of immune cells in the airways of children and enhanced cytokine‐based interactions with epithelial cells tune the setpoint of the epithelial antiviral system. Our findings shed light on the molecular basis of children's remarkable resistance to COVID‐19 and may suggest a novel concept for immunoprophylactic treatments.
Ideology and Theatre Translation in Contemporary Turkish Theatre
Authors: Bozkurt Jobanputra Seyhan , Zeki Giritli Mehmet 
Published: October 2023

This paper aims to explore the relationship between drama translation and ideology in contemporary Turkish theatre. After delineating the distinction between state/city theatres and independent (private/alternative) theatres, it will then focus on the 2000s with a special emphasis on the translation activities of independent (private/alternative) theatres. In particular, it shall draw attention to how actor/director translators working with or for these theatres have become significant cultural agents and have challenged the status quo by either choosing to translate plays with provocative content or by retranslating plays that were forced to undergo (self-)censorship. The paper will also challenge the general impression in the Turkish context that the reason for retranslating classical plays into Turkish is merely a need to follow and reflect contemporary changes in the language.
Maria Hablevych and the Concept of Truth in 'Hamlet'
Authors: Sverediuk Anna 
Published: October 2023

The paper is focused on the interpretation of the notion of Truth in Ukrainian translations of Hamlet through the lenses of the contemporary Ukrainian Shakespeare Studies scholar Maria Hablevych (1950). In particular, it deals with the reproduction of Truth based on the notion of agent’s professional habitus, which is regarded as a heterogeneus entity with several sub-habiti. The paper is an attempt to prove that multifaceted agency as the result of complex habitus, reflected in the agent’s hexis, or style, facilitates better understanding and re-interpretation of the issues raised in Shakespeare’s tragedy. The research touches upon the Ukrainian translator-agents, with some of them being committed to more than one agency, to trace the influence of the existing restrictive norms on their habiti and the respective interpretation of Truth in Shakespeare’s tragedy.
Ahmed Ibn Fadlan and Bayard Taylor: Travel Writers or Translators?
Authors: Elbarbary Ayman S. 
Published: October 2023

In this article, two works of travel writing, Resala (922) by Ahmed Ibn Fadlan and Travels in Arabia (1889) by Bayard Taylor, are explored to show how the genre as a whole serves as one way of translating culture in order to better understand and discover it. It examines how ideology affects cultural translation in travel writing and how this leads to othering. We begin with close readings of the texts for major content themes, including religion, sex, traditions, etc. These are analyzed for instantiations of inaccurate cultural translation, ideology, and othering. The use of pronouns, nouns, and adjectives is looked at to explore their othering effect. The results show that inaccurate cultural translations are sometimes influenced by ideology and usually lead to othering. The analyzed samples of travel writing rather reveal the predominant mindsets and leanings of their authors and cultures of their origin than those they attempt to introduce to their readers.
Social chatbot use (e.g., ChatGPT) among individuals with social deficits: Risks and opportunities
Authors: Franze Andrew , Galanis Christina R. , King Daniel L. 
Published: October 2023

AbstractSocial chatbots powered by artificial intelligence (AI) may be particularly appealing to individuals with social deficits or conditions that affect their social functioning. In this letter, we discuss some of the noteworthy characteristics of social chatbots and how they may influence adaptive and maladaptive behaviors, including the potential for ‘dependency’ on chatbots. We call for more independent studies to evaluate the potential developmental and therapeutic effects of this increasingly popular technology.
Służebny charakter kapłańskiej posługi w nauczaniu Jana Pawła II
Authors: Damasiewicz Małgorzata 
Published: October 2023

Kapłan na mocy święceń zostaje upodobniony do Jezusa, Dobrego Pasterza, i powołany do naśladowania Go oraz przeżywania Jego miłości pasterskiej, bezinteresownej, miłości, która kieruje się zwłaszcza ku najbiedniejszym i sytuuje wobec nich w postawie służebnej. Przyjęcie tej postawy jest znakiem przyjęcia odpowiedzialności, jaką nakłada na kapłana Boże wybranie, a zarazem jest znakiem potwierdzenia tej pasterskiej miłości.
Przypowieść o sieci (Mt 13, 47–50) jako inspiracja dla duszpasterstwa
Authors: Wąchol Grzegorz 
Published: October 2023

Biblijna przypowieść o sieci dostarcza danych obecnych w obrazach Kościoła, które można odnieść do współczesnej sytuacji duszpasterskiej. Mocno oddziałują na nią zmiany społeczne modyfikujące podejście Kościoła i duszpasterzy do wiernych oraz roli, jaką pełnią wobec nich. Artykuł zwraca uwagę na istotne elementy pracy duszpasterskiej, które wyznaczają jej właściwy cel.
Chrystoformizacja jako fundament moralności
Authors: Wszołek Andrzej 
Published: October 2023

Teologię chrześcijańskiego życia wyznacza horyzont jedności z Bogiem. Człowiek wyszedł z rąk Boga jako stworzenie doskonałe. Życie z Bogiem jest święte, szczęśliwe i wieczne i takim życiem Bóg obdarował człowieka w akcie stwórczym. Harmonię i jedność człowieka z Bogiem, do której został on powołany, naruszył grzech pychy pierwszych rodziców (grzech pierworodny). To nie Bóg odrzucił człowieka, lecz człowiek oddalił się od Boga. Bóg szuka człowieka, który po grzechu ma trudność z określeniem siebie i sensu swojego życia. Tylko Bóg może pomóc człowiekowi, tymczasem on „ukrywa się” przed Nim, jak przed kimś, kto chce go skrzywdzić. Tę sytuację odwrócenia się od Boga „odkupił” przez swoją śmierć i zmartwychwstanie Jezus Chrystus, Bóg-Człowiek, czyniąc człowieka na nowo dzieckiem Boga. Chrześcijanin to ten, który jest Chrystusowy i w Chrystusie — Synu Bożym jest usynowiony. Naśladując Chrystusa-Człowieka Doskonałego, człowiek upodabnia się do Niego (chrystoformizuje).
Forming the maxillary palatal relief on the outer palatal surface of the complete removable dentures
Authors: Bayramov Y.I.  
Published: October 2023

Prosthodontic treatment of secondary complete adentia in the upper jaw with completely removable plate prothesis consists in reflecting the palatal relief on the outer surface of the upper jaw prosthesis basis. Preparation of CRPP for SCA is an arrangement of known clinical and laboratory stages.
During the prosthodontic treatment of SCA with maxillary CRPP, the following sequence was performed at the clinical and laboratory stages for the purpose of reflection of the palatal relief on the outer side of the maxillary prosthetic bases, the 2nd and 4th laboratory stages have been improved. So that:
Replacing the wax with plastic in the composition of complete removable dentures. 4,5,6,7,8 figures of our work refer to this stage. At this stage: Figure 8-reflection of the relief of a part of the hard palate in the base plate wax added to the trial denture of a maxillary complete removable platen prosthesis. Figure 9-reflection of the relief of a part of the hard palate in the denture wax added to the trial denture of a maxillary complete removable platen prosthesis.
The present study shows that the complete removable upper plate prosthesis (CRPP) is more functional in the prosthetic treatment of secondary complete adentia (SCA). By using CRPP on the upper jaw, unnatural disturbances in the relief of the palatine region are eliminated. It will be useful for improving other clinical and laboratory stages of preparation of maxillary CRPP.
Coseismic and Early Postseismic Slip of the 2021 Mw 7.2 Nippes, Haiti, Earthquake: Transpressional Rupture of a Nonplanar Dipping Fault System
Authors: Li Zhen , Wang Teng 
Published: October 2023

Abstract
On 14 August 2021, an Mw 7.2 earthquake struck Nippes, Haiti, 11 yr after the devastating 2010 Mw 7.0 Port-au-Prince earthquake. This earthquake occurred in a remote region where the structure at the depth of the main boundary Enriquillo Plantain Garden fault (EPGF) is less known. Using Synthetic Aperture Radar imagery, we retrieve the coseismic and early postseismic deformation of the 2021 Haiti earthquake to constrain its fault geometry and slip distribution. Our modeling results show that the 2021 earthquake ruptured the high-angle Ravine du Sud fault and a bend fault ∼64° dipping to the north at depth. Although not only conclusive, the combination of coseismic and postseismic deformation, along with geomorphic features, and relocated aftershocks, suggest a nonplanar fault structure with significant variations in dip angles along both the depth and track of the EPGF in this region. East of the epicenter, we document a 25 km section along the EPGF that crept for ∼15 days. This distribution of aseismic slip utilizing stacked deformation indicates that only a small fraction of the accumulated strain near the surface was released during the earthquake, suggesting a high potential for seismic hazard in the region along the EPGF from the ruptured segment to the east, before reaching the 2010 rupture.
Role of Efflux Pump Gene adeIJK to Multidrug Resistance in Acinetobacter baumannii Clinical Isolates
Authors: Ji Ae Choi  , Choon-Mee Kim  , Sook-Jin Jang  , Seong-Sik Cho  , Chul Ho Jang  , Young-Jin Ko  , Seong-Ho  Kang  , Geon Park  
Published: October 2023

Background: The emergence of multidrug-resistant Acinetobacter baumannii (MDRAB) as a nosocomial pathogen is one of the major public health problems. This study aimed to evaluate the role of an efflux pump gene adeJ for the multidrug resistance of A. baumannii clinical isolates. Methods: Two groups, MDRAB and susceptible A. baumannii (SAB), of baumannii clinical isolates were studied. The SAB group consisted of strains that did not meet the criteria of MDRAB and were susceptible to more categories of antibiotics than MDRAB. Antimicrobial susceptibility results obtained by the VITEKⅡ system were used in data analysis and bacterial group allocation. We performed real-time reverse transcription PCR to determine the relative expression of adeJ. We compared the relative expression of adeJ in comparison groups by considering two viewpoints: (1) MDRAB and SAB groups,and (2) susceptible and non-susceptible groups for each antibiotic used in this study.Results: The mean value of relative expression of adeJ of MDRAB and SAB groups was 1.4 and 0.92, respectively, and showed significant differences (P = 0.002). The mean values of relative expression of adeJ of susceptible and non-susceptible groups to the antibiotics cefepime, ceftazidime, ciprofloxacin, imipenem, meropenem, tigecycline, piperacillin/tazobactam, ticarcillin/clavulanic acid, trimethoprim/sulfamethoxazole, piperacillin, and gentamicin showed statistically significant differences (P < 0.05). Conclusion: The overexpression of adeIJK might contribute to the multi-drug resistance in A. baumannii clinical isolates. Further, the overexpression of adeIJK might be one of the factors contributing to the resistance to numerous antibiotics.