bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergency exit layout planning using optimization and agent-based simulation
Authors: Barth Maren S. , Palm Katharina , Andersson Henrik , Granberg Tobias A. , Gullhav Anders N. , Krüger Andreas 
Published: October 2023

AbstractEvacuation preparedness includes ensuring proper infrastructure, resources and planning for moving people from a dangerous area to safety. This is especially important and challenging during mass gatherings, such as large concerts. In this paper, we present the Emergency Exit Layout Problem (EELP) which is the problem of locating a given number of emergency exits and deciding their width such that the time it takes to evacuate the crowd from an arena is minimized. The EELP takes into account the geography of the arena and its surroundings, as well as the number of pedestrians in the crowd and the distribution of these within the arena. The EELP is formulated as a two-stage stochastic mixed integer linear program to handle the uncertainty related to the location of the possible incidents and the distribution of the pedestrians. Two cases are studied, a large concert planned at the Leangen trotting track in Trondheim and a smaller indoor arena. For each case, the EELP is solved for different scenarios, and the suggested layouts are evaluated using an agent-based simulation model. In particular, the potential of incorporating detailed assessment regarding the location and probability of specific incidents and the distribution of pedestrians are investigated. The computational study shows that making a more detailed risk assessment has little effect on the large concert, but a significant impact on the location of the emergency exits for the smaller indoor case. The results also indicate that it is more important to consider the location and probability of specific incidents rather than the pedestrian distribution.
Stochastic Modeling of Partially Stirred Reactor (PaSR) for the Investigation of the Turbulence-Chemistry Interaction for the Ammonia-Air Combustion
Authors: Yu Chunkan , Cai Liming , Chen Jyh-Yuan 
Published: October 2023

AbstractThe Partially Stirred Reactor (PaSR) model is carried out for the ammonia-air combustion system by means of stochastic modeling, namely by solving the transport equation for the joint Probability Density Function (PDF). The turbulent mixing is accounted for by the Linear Mean-Square Estimation (LMSE) mixing model. Notwithstanding the simplified nature of the PaSR modeling, the transported-PDF method enables capturing the effect of mixing frequency on the combustion system, especially the NOx emission. Since the chemical source term is in a closed form in the transported-PDF method, it allows us to apply different chemical mechanisms to explore, whether the set of elementary reactions that are identified as important for the prediction of NOx in the PaSR model is sensitive to the choice of chemical mechanisms. Furthermore, the effect of the residence time in the PaSR model has also been studied, and compared with those in the Perfectly Stirred Reactor (PSR) model (infinite large mixing frequency). Moreover, since the ammonia under oxygen enrichment shows some similar combustion behaviors in terms of e.g. laminar burning velocity as the ammonia under hydrogen enrichment, how large the difference of thermo-kinetic states (e.g. temperature and NOx emission) predicted by PaSR models and in laminar premixed flame configuration is also investigated. A further discussion focuses on the effect of thermal radiation, where the radiative heat loss roles in the prediction of NOx for the turbulent simulation is examined. By using the optically thin approximation model, it is shown that the thermal radiation exhibits little effect on the considered combustion systems within a typical turbulent time-scale.
Multi-robot geometric task-and-motion planning for collaborative manipulation tasks
Authors: Zhang Hejia , Chan Shao-Hung , Zhong Jie , Li Jiaoyang , Kolapo Peter , Koenig Sven , Agioutantis Zach , Schafrik Steven , Nikolaidis Stefanos 
Published: October 2023

AbstractWe address multi-robot geometric task-and-motion planning (MR-GTAMP) problems in synchronous, monotone setups. The goal of the MR-GTAMP problem is to move objects with multiple robots to goal regions in the presence of other movable objects. We focus on collaborative manipulation tasks where the robots have to adopt intelligent collaboration strategies to be successful and effective, i.e., decide which robot should move which objects to which positions, and perform collaborative actions, such as handovers. To endow robots with these collaboration capabilities, we propose to first collect occlusion and reachability information for each robot by calling motion-planning algorithms. We then propose a method that uses the collected information to build a graph structure which captures the precedence of the manipulations of different objects and supports the implementation of a mixed-integer program to guide the search for highly effective collaborative task-and-motion plans. The search process for collaborative task-and-motion plans is based on a Monte-Carlo Tree Search (MCTS) exploration strategy to achieve exploration-exploitation balance. We evaluate our framework in two challenging MR-GTAMP domains and show that it outperforms two state-of-the-art baselines with respect to the planning time, the resulting plan length and the number of objects moved. We also show that our framework can be applied to underground mining operations where a robotic arm needs to coordinate with an autonomous roof bolter. We demonstrate plan execution in two roof-bolting scenarios both in simulation and on robots.
From the forest to the city: the persistence of dragonflies and damselflies in the urban jungle
Authors: Suárez-Tovar Catalina M. , Rocha-Ortega Maya , Juen Leandro , Córdoba-Aguilar Alex 
Published: October 2023

AbstractUrbanization has driven one of the most substantial transformations in water bodies exposing groups such as aquatic insects to new challenging conditions. Some odonate (dragonflies and damselflies) species persist in these transformed environments, but it remains unclear which morphological or behavioral traits allow them to survive. Through a bibliographical review we identified 88 urbanization-tolerant and 87 urbanization-sensitive odonate species worldwide. We searched morphological and behavioral traits and used phylogenetic path analysis for Anisoptera and Zygoptera to test which traits make species more sensitive to urban environments. Our results show that habitat preference was not linked with the sensitivity to urbanization whereas larger species with weak sexual dimorphism stood out as consistently associated with sensitivity to urban environments. For dragonflies, species with yellow to red colorations tend to be less sensitive to urban areas while for damselflies, territorial species tend to be less sensitive to urban areas. We discuss the underlying mechanisms linked to such urban-surviving ability as well as how we can use such information for conservation purposes.
The Independence of Judges and Corporate Social Responsibility
Authors: Miao Senlin , Tian Gary Gang , Wen Fenghua , Xiao Jinli 
Published: October 2023

AbstractLimited research has focused on the influence of judge independence on firms' corporate social responsibility (CSR), despite extensive literature examining the impact of the legal environment on CSR. To address this gap, we analyze the staggered adoption of judicial delocalization reform in China. This reform aimed to enhance local judges' independence and our analysis shows that firms have exhibited higher CSR scores since its implementation. Our channel analysis reveals an increase in lawsuits and monetary claims against firms due to the reform, indicating that firms engage in CSR activities to mitigate the negative effects of legal proceedings. The impact of the reform on CSR is stronger for high-litigation-risk firms and weaker for politically connected firms. Moreover, the positive relationship between the reform and CSR is more pronounced in regions with higher levels of government interference with judges before the reform. In summary, our findings highlight the important role of a supportive legal environment in fostering CSR, emphasizing the influence of judge independence.
LOC102549726/miR-760-3p network is involved in the progression of ISO-induced pathological cardiomyocyte hypertrophy via endoplasmic reticulum stress
Authors: Chen Bangsheng , Tan Lian , Wang Ying , Yang Lei , Liu Jiequan , Chen Danqi , Huang Shuaishuai , Mao Feiyan , Lian Jiangfang 
Published: October 2023

AbstractPathological cardiac hypertrophy (CH) is featured by myocyte enlargement and cardiac malfunction. Multiple signaling pathways have been implicated in diverse pathological and physiological processes in CH. However, the function of LOC102549726/miR-760-3p network in CH remains unclear. Here, we characterize the functional role of LOC102549726/miR-760-3p network in CH and delineate the underlying mechanism. The expression of LncRNA LOC102549726 and hypertrophic markers was significantly increased compared to the control, while the level of miR-760-3p was decreased. Next, we examined ER stress response in a hypertrophic cardiomyocyte model. The expression of ER stress markers was greatly enhanced after incubation with ISO. The hypertrophic reaction, ER stress response, and increased potassium and calcium ion channels were alleviated by genetic downregulation of LOC102549726. It has been demonstrated that LOC102549726 functions as a competitive endogenous RNA (ceRNA) of miR-760-3p. Overexpression of miR-760-3p decreased cell surface area and substantially mitigated ER stress response; protein levels of potassium and calcium channels were also significantly up-regulated compared to the NC control. In contrast, miR-760-3p inhibition increased cell size, aggravated CH and ER stress responses, and reduced ion channels. Collectively, in this study we demonstrated that the LOC102549726/miR-760-3p network was a crucial regulator of CH development. Ion channels mediate the ER stress response and may be a downstream sensor of the LOC102549726/miR-760-3p network. Therefore, these findings advance our understanding of pathological CH and provide new insights into therapeutic targets for cardiac remodeling.
Management of ulcerative colitis by dichloroacetate: Impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification
Authors: Abdel-Razek Esraa Abdel-Nassir , Mahmoud Heba M. , Azouz Amany A. 
Published: October 2023

AbstractThe inflammatory response in ulcerative colitis (UC) could be relieved by the conventional immunomodulatory agents; 5-aminosalicylic acid, corticosteroids, or azathioprine. However, the low remission rates and the intolerance to these agents necessitate investigation of gene expression signature in UC that could influence the therapeutic efficacy of drugs, as well as the interference with persistence genes by novel therapeutic option. Three microarray datasets (GSE66407, GSE38713 and GSE14580) from the NCBI-GEO database were utilized. Differentially expressed genes between samples of patients with UC and healthy ones were analyzed using R software. In addition, in vivo study using oxazolone-induced UC in BALB/c mice was carried out to investigate the proposed therapeutic efficacy of dichloroacetate (DCA). The bioinformatics analysis revealed the persistence of NLRP3, NFATC1, and IL1B in UC despite treatment with common therapeutic agents. DCA administration to oxazolone-treated mice showed remarkable interference with those persistence genes. Western blotting analysis for NLRP3, NFATC1, nuclear/total NF-κB, and cleaved caspase-1 revealed the ability of DCA to reduce the expression levels of these proteins in oxazolone-treated mice. Additionally, the inflammatory cytokines IL-1β and IL-13 were reduced in colonic tissue by DCA treatment. The therapeutic efficacy of DCA was further confirmed by the apparent reduction in histopathological scoring, disease activity index, and the normalization of colon length. Therefore, DCA could be suggested as a novel and promising therapeutic option in UC based on its ability to interfere with the persistence of NFATC1/NLRP3/IL1B signaling. That merits further safety/toxicological pre-clinical assessment and update of bioavailability/metabolism data prior to clinical investigation.
Development and Preliminary Analysis of a Scale to Assess Client Characteristics that Influence Clinical Decision-Making
Authors: Faustino Bruno , Vasco António Branco 
Published: October 2023

AbstractUnderstanding client variables relevant to clinical decision-making is a core feature of psychotherapy. The previous meta-analysis emphasized variables related to stages of psychotherapy, motivational stages of change, alliance, reactance, coping, attachment styles, and emotional stability in psychotherapy outcomes. However, a clinical measure that captures these empirically based clinical variances is missing. The present study describes the development and preliminary analysis of the Clinical Decision-Making Inventory (CDMI) in a sample of individuals engaged in a psychotherapeutic process. One hundred and twenty-three participants (M = 20.28, SD = 5.80) engaged in a psychotherapy process, were assessed in a cross-sectional design. On one hand, the stages of psychotherapy, motivational stages of change, reactance, coping, attachment styles, and emotional stability were negatively correlated with symptomatology, cognitive fusion, interpersonal problems, coping mechanisms, and expressive suppression. On the other hand, correlated positively with metacognition and cognitive reappraisal. Attachment style and emotional stability predicted symptomatology. The CDMI showed promising results; however, more research is required to deepen the psychometric analysis.
Sampling, characterization, method validation, and lessons learned in analysis of highly activated stainless steel from reactor decommissioning
Authors: Leskinen Anumaija , Salminen-Paatero Susanna , Leporanta Jussi , Hytönen Noora , Bourgeaux-Goget Marie , Räty Antti 
Published: October 2023

AbstractCharacterisation of activated reactor components is a multifaceted effort, which include both experimental work and activation calculations which together form a comprehensive characterisation approach. However, both the experimental work and activation calculations have their constraints and uncertainties. This work presents the characterisation of a highly activated stainless steel pipe including sampling planning, sampling, sub-sampling, elemental and radionuclide analyses, and activation calculations. 55Fe, 63Ni and 60Co analyses were carried out in a trilateral intercomparison exercise and the results were compared with activation calculations. The results showed excellent alignment between experimental and activation calculation results.
Identifying the Health Concerns of Pregnant British Pakistani Women Living in Deprived Areas: A Qualitative Study
Authors: Iqbal Halima , West Jane , McEachan Rosemary R. C. , Haith-Cooper Melanie 
Published: October 2023

Abstract
Introduction
Pregnant British Pakistani women have disproportionately poorer health than the wider population. Bradford has a strong Pakistani presence and a wide range of public health problems including high levels of gestational diabetes, high obesity rates and a high infant mortality rate, which is highest for babies of Pakistani origin. For women to be healthy, we need to know what concerns they have about their health so they can be addressed appropriately. The aim of this study, therefore, was to explore the health concerns of pregnant British Pakistani women living in deprived areas.

Methods
Semi-structured qualitative interviews were conducted with 21 pregnant Pakistani women in a hospital setting. Data were analysed using thematic analysis.

Results
Pakistani women identified safety issues, barriers to undertaking physical activity in the areas where they live, concerns surrounding exercising during pregnancy and cultural and religious constraints that prevented them from engaging in physical activity. They reported issues around food, concerns around a lack of culturally appropriate diet information, the cost of unhealthy food locally, and the lack of healthy food options in their residences. Women were unsure on where to obtain health promotion information and reported a lack of access in obtaining that information. Language barriers in accessing health promotion information were further reported as a concern.

Discussion
Researchers, midwives, health providers, local authority and policy makers interested in improving the health of pregnant Pakistani women may use these findings to develop further research and interventions to improve the poor health of this population.
Identification of health-related quality of life profiles among long-term survivors of primary central nervous system tumors
Authors: Stockdill Macy L. , Mendoza Tito , Armstrong Terri S. , Miaskowski Christine , Cooper Bruce , Vera Elizabeth 
Published: October 2023

Abstract
Purpose
We aimed to identify health-related quality of life (HRQOL) latent classes among primary central nervous system tumor (PCNST) long-term survivors (LTS) and to evaluate differences between classes in survivor sociodemographic characteristics, clinical characteristics, and symptoms to guide the development of survivorship care programs tailored to unique class needs.

Methods
Data from 298 PCNST LTS reporting HRQOL on the EQ-5D-3L were analyzed using latent profile analysis. Correlations and independent group t-tests were performed to identify differences between identified HRQOL classes by sociodemographic, clinical characteristics, and symptoms.

Results
Sample mean age was 48 years, 54% were male, 82% Caucasian, 56% employed, 60% had a high-grade glioma, and 52% had a KPS ≥ 90. Two HRQOL classes, good (61%) and poor (39%), were identified. The good HRQOL class reported no problems with self-care and few problems with mobility or usual activities. Thirty-eight percent reported anxiety and depression and 21% pain. Over 94% of the poor HRQOL class had at least moderate problems with mobility and usual activities, and over 50% had pain, self-care issues, anxiety, and depression. Older age (φ = 0.21), unemployment (φ = 0.30), spine tumors (φ = 0.18), active treatment (φ = 0.20), tumor recurrence (φ = 0.28), and poorer KPS scores (φ = 0.61) were associated with membership in the poor HRQOL class.

Conclusions
In the poor PCNST LTS HRQOL class, an overwhelming majority faced significant physical challenges, and the good HRQOL class experienced mood-related disturbance but limited physical challenges. These HRQOL profiles can be used to guide survivorship programs and tailored interventions.
The slope of assimilation rate against stomatal conductance should not be used as a measure of water use efficiency or stomatal control over assimilation
Authors: Bellasio Chandra 
Published: October 2023

AbstractQuantifying water use efficiency, and the impact of stomata on CO2 uptake are pivotal in physiology and efforts to improve crop yields. Although tempting, relying on regression slopes from assimilation-stomatal conductance plots to estimate water use efficiency or stomatal control over assimilation is erroneous. Through numerical simulations, I substantiate this assertion. I propose the term ‘instantaneous transpiration efficiency’ for the assimilation-to-transpiration ratio to avoid confusion with ‘intrinsic water use efficiency’ which refers to the assimilation-to-stomatal conductance ratio, and recommend to compute both metrics for each gas exchange data point.
Quality of patient-reported outcome measures for primary dysmenorrhea: a systematic review
Authors: Piontek Katharina , Gabes Michaela , Kann Gesina , Fechtner Marie , Apfelbacher Christian 
Published: October 2023

Abstract
Purpose
To conduct a systematic review of the quality of patient-reported outcome measures (PROMs) for primary dysmenorrhea (PDys) using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology, and to derive recommendations for use of the PROMs.

Methods
We searched PubMed and Web of Science for studies reporting on the development and/or validation of any PROMs for women with PDys. Applying the COSMIN Risk of Bias Checklist, we assessed the methodological quality of each included study. We further evaluated the quality of measurement properties per PROM and study according to the criteria for good measurement properties, and graded the evidence. Based on the overall evidence, we derived recommendations for the use of the included PROMs.

Results
Data from seven studies reporting on four PROMs addressing different outcomes were included. Among those, the Adolescent Dysmenorrhic Self-Care Scale (ADSCS) and the on-menses version of the Dysmenorrhea Symptom Interference Scale (DSI) can be recommended for use. The Exercise of Self-Care Agency Scale (ESCAS) and the Dysmenorrhea Daily Diary (DysDD) have the potential to be recommended for use, but require further validation. The off-menses version of the DSI cannot be recommended for use.

Conclusions
The ADSCS can be recommended for the assessment of self-care behavior in PDys. Regarding measures of impact, the on-menses version of the DSI is a suitable tool. Covering the broadest spectrum of outcomes, the DysDD is promising for use in medical care and research, encouraging further investigations. Further validation studies are indicated for all included PROMs.
Which Elections? A Dilemma for Proponents of the Duty to Vote
Authors: Rusavuk Andre Leo 
Published: October 2023

AbstractProponents of the duty to vote (DTV) argue that in normal circumstances, citizens have the moral duty to vote in political elections. Discussions about DTV analyze what the duty is, who has this duty, when they have it, and why they have it. Missing are answers to the Specification Question: to which elections does DTV apply? A dilemma arises for some supporters of DTV—in this paper, I focus on Julia Maskivker’s work—because either answer is problematic. First, I argue that it is implausible that DTV applies to all elections because this makes the duty too costly for the voter. Second, I argue that there are no good reasons why under normal circumstances DTV applies only to some elections. I consider objections but conclude that the dilemma is successful and therefore the case for DTV is incomplete.
Penalty or Reward? The Role of Hybrid Identities in Social Enterprises’ Resource Acquisition
Authors: Ji Chen , Konrath Sara 
Published: October 2023

AbstractResource acquisition is important for social enterprises’ resilience. Prior studies have explored social enterprises’ hybridity and resource acquisition outcomes, but have ignored funders’ heterogeneity. This paper examines how the identities of both social enterprises and financial resource providers are associated with financial resource acquisition. We specifically study how social enterprises’ social and financial identities are related to the acquisition of financial resources. Using an international entrepreneurship database (2014–2019), we find that social enterprises receive financial support from equity investors in a similar way as pure for-profits, while social enterprises receive less support from philanthropic donors, compared to pure nonprofits. We discuss the implications for social entrepreneurship research and practice.