bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study of Depression among Infertile Women of Reproductive Age Group Attending Tertiary Care Hospitals in Agartala
Authors: Debbarma Nanimala , Jamatia Raja , Reang Taranga 
Published: October 2023

Background:
Fertility phenomenon is a physiological process in living organisms that in human in addition to physiological aspects has social and psychological dimensions.

Objectives:
To estimate the proportion and associated risk factors of depression among infertile women of reproductive age group.

Methodology:
A cross sectional study was conducted in the tertiary care level of Obstetrics & Gynecology Clinics in the Agartala city. BDI scale was used for assessing the depression level among infertile women.

Result:
The proportion of depression was 54%. One percent severe depression and 5% moderate depression. There was significant association of depression with age group, educational status, and number of family member, duration of marriage, caste and with religion of the infertile women.

Conclusion:
The proportion of the depression morbidity was high among infertile women. The proportion of depression should not be underestimated in the women suffering from infertility. Apart from searching for the obstetrical causes of infertility; psychological morbidity should also be considered as a serious concern affecting these women.
Need for Age-Specific Prostate-Specific Antigen Reference Intervals in a Nigerian Population
Authors: Okafor Edwin N. , Okonkwo Innocent N. , Nubila Nkoyo I. , Ugonabo Martin C. 
Published: October 2023

ABSTRACT

Background:
In Nigeria, the diagnostic value of prostate-specific antigen (PSA) is a matter of debate. PSA levels are known to vary with population, environmental factors, and advancing age. Studies suggest age-specific reference intervals (ASRIs) of PSA value are more accurate than single cut-off PSA value. For ASRIs to be used effectively, reference intervals (RIs) must be fully evaluated.

Aim:
We determine ASRIs in a Nigerian population.

Materials and Methods:
The study was carried out from January 2016 to January 2019 among 660 adult Nigerian men aged 30–86 years old in Enugu State. Participants completed questionnaire demographics and previous screening. Age group was the indicator. Among them, a total 24 (3.6%) were excluded. Data from 636 (96.4%) men were analyzed for ASRIs. Estimation of PSA was done as per the International Federation of Clinical Chemistry Guideline. Spearman correlation was used to identify correlates P values < 0.05 which was considered significant.

Results:
The mean age group was 49.6 ± 10.2 years. ASRIs using 95th percentile, and PSA values in each 10 years groups were 0–1.94 ng/ml (median 0.22), 0–2.52 ng/ml (median 0.42), 0–3.52 ng/ml (median 1.06), 0–4.8 ng/ml (median 2.1), 0–6.95 ng/ml (median 4.1), and 0–5.6 ng/ml (median 2.4), for age groups 30–39, 40–49, 50–59, 60–69, 70–79, and ≥80 years, respectively. There was positive correlation between PSA and age (r = 0.9915, P < 0.0001). Low income and educational background were more prevalent among the study group.

Conclusion:
Our study provided the ASRIs in our environment but higher than single cut-off value. The data recommended PSA values should be characterized by age and ethnicity.
The Prognostic Impact of Comorbidity, Nutritional and Performance Status on Patients with Diffuse Large B Cell Lymphoma
Authors: Sağlam B , Albayrak M , Yıldız A , Tığlıoğlu P , Tığlıoğlu M , Aras MR , Yılmaz F , Maral S , Öztürk HBA 
Published: October 2023

ABSTRACT

Background:
The aim of the study was to investigate the impact of nutritional status, comorbidity, and performance status on patients with diffuse large B-cell lymphoma (DLBCL).

Methods:
A retrospective study was conducted on 112 DLBCL patients who were diagnosed at our center between 2009 and 2018. Demographic and disease characteristics and laboratory test results were recorded. Assessments were made using the age-adjusted Charlson comorbidity index (CCI-A) for comorbidity, albumin level for nutritional status, and Eastern Cooperative Oncology Group (ECOG) score for performance status.

Results:
The mean age of the patients was found to be 62.63 ± 15.16 years. The ECOG score of 65 patients (69.1%) was in the range of 0–1. The mean follow-up time of the patients was determined to be 25.24 ± 25.11 months, and at the end of the follow-up period, 64 patients (57.1%) were survivors. The progression-free survival (PFS), overall survival (OS), and 5-year OS rates of those with CCI-A > 4 were found to be significantly lower than those with CCI-A score ≤4 (P < 0.05). As a result of the Cox-Regression (Backward: LR method) analysis, ECOG and albumin levels were found to be independent risk factors for both OS and PFS (P < 0.05).

Conclusion:
This study demonstrated that CCI-A, ECOG, and nutritional status are independent prognostic markers for DLBCL patients. Initial evaluation of these patients should include all these parameters, which are easily available at the time of diagnosis.
Effectiveness of Kinesiologic Taping on Function and Pain in Patients With Hemophilia A
Authors: Kazanci Elif G. , Kaya Erkan , Güven Deniz 
Published: October 2023

ABSTRACT

Background:
Hemophilic arthropathy frequently results in musculoskeletal adjustments that impair functional capacity.

Aim:
We investigated the effects of kinesiologic taping on patients with hemophilic arthropathy in this study.

Materials and Methods:
Twenty-six patients were enrolled. Thirteen patients formed the Kinesiologic taping group (KT) and received the interventional protocol consisting of three kinesiologic taping sessions during three weeks; and 13 patients formed the control group (CG) and made three weeks of home exercises. All patients were evaluated using the Functional Independence Score in Hemophilia (FISH), Hemophilia Joint Health Score (HJHS), and Visual Analog Scale (VAS) at baseline, one week, and three weeks.

Results:
The mean scores for the VAS, HJSS, and FISH differed significantly before and after 3 weeks in both groups (P < 0.001). However, the differences in medians after the treatment were significantly greater in the KT group than in the CG group (P < 0.001).

Conclusions:
Kinesiologic taping was associated with physical improvement in hemophilia patients; however, also kinesiologic taping led to significant improvement in VAS scores.
Biomechanical Behavior of Carbon Fiber-Reinforced Polyetheretherketone as a Dental Implant Material in Implant-Supported Overdenture under Mandibular Trauma: A Finite Element Analysis Study
Authors: Bilginaylar K , Ayali A 
Published: October 2023

ABSTRACT

Context:
Implant-supported overdentures are well-known and widely accepted treatment modality to increase retention which is a crucial factor for determining patient satisfaction. The placement of two implants in the anterior region can be selected as a first-line treatment in patients with the atrophic mandibular ridge.

Aims:
The purpose of this research was to assess the biomechanical effects of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) implant-supported overdenture in the event of 2,000 N forefront trauma to an atrophic edentulous mandible by using the finite element analysis method.

Materials and Methods:
Three types of mandible models were simulated; the first one was an edentulous atrophic mandible model; in the second model, 3.5 × 11.5 mm CFR-PEEK implants; and in the third model, 4.3 × 11.5 mm CFR-PEEK implants were positioned in the region of the lateral incisor of the identical edentulous atrophic mandible.

Results:
Maximum Von Misses stresses 979.261 MPa, 1,454.69 MPa, and 1,940.71 MPa and maximum principal stresses 1,112.74 MPa, 1,249.88 MPa, and 1,251.33 MPa have been detected at the condylar neck area and minimum principal stresses − 1,203.38 MPa, −1,503.21 MPa, and − 1,990.34 MPa have been recorded at the symphysis and corpus regions from M1 to M3, respectively. In addition, the M2 and M3 models showed low-stress distributions around the implant–bone interface, particularly where the implants were in contact with cancellous bone.

Conclusions:
The results showed that the insertion of different diameters of CFR-PEEK implants led to low and homogenous stress distribution all around the implant–bone interface and stresses transferred directly to the condylar neck areas. Therefore, it was observed that CRF-PEEK implants did not change the basic behavior of the mandibula in response to frontal stresses.
Changes in and the Relationships between Alpha-Klotho, Oxidative Stress, and Systemic Inflammation in Cigarette Smokers
Authors: Solak I , Guney I , Kurku H , Gederet YT , Eryilmaz MA 
Published: October 2023

ABSTRACT

Background:
Although smoking is known to accelerate aging, the mechanisms by which this occurs have not been fully clarified. Serum-soluble α-Klotho (sαKl), antiaging, anti-inflammatory, and developing resistance to oxidative stress properties are known.

Aim:
This study aimed to determine the relationship between cigarette smoking, saKl (antiaging hormone), inflammation, and oxidative stress.

Materials and Methods:
Participants included in the study were divided into smoking and nonsmoking groups. sαKl, high-sensitivity C-reactive protein (hsCRP), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed and compared in the study participants.

Results:
There were one hundred and forty-six study participants comprising 47 (32.2%) females and 99 (67.8%) males. There were 79 (54.1%) in the nonsmoking group and 67 (45.9%) in the smoking group. A significant difference was found between the groups in respect of TAS (P < 0.001), OSI (P = 0.017), sαKl (P = 0.013), and hsCRP (P = 0.024) values. A significant negative correlation was found between the sαKl values of the smoking group and the years of smoking (r = -0.271, P = 0.038) and pack-years (r = -0.299, P = 0.021). Among the smoking group, a lower median sαKl value of <3.84 pg/ml was significantly associated with years of smoking (P = 0.028) and pack-years (P = 0.012).

Conclusions:
This study found that sαKl, OSI, and hsCRP were elevated in those who smoke cigarette. Large prospective studies are needed to further elucidate this area of research.
Diagnostic Usefulness of Serum Procalcitonin in Patients with Bacterial Sepsis
Authors: Maigari IM , Jibrin YB , Gwalabe SA , Dunga JA , Abdu A , Umar MS , Hassan HF , Ballah AM , Sulaiman MH 
Published: October 2023

ABSTRACT

Background:
The Sequential Organ Failure Assessment (SOFA) score is used for the diagnosis of sepsis and involves clinical and laboratory parameters that may not be readily and/or timely available in most resource-poor settings. Procalcitonin (PCT) has its level changed in response to bacterial sepsis and its measurement costs only a fraction of the total cost of investigations required to calculate SOFA score. This study aims to determine the diagnostic usefulness of PCT in bacterial sepsis.

Materials and Methods:
Ninety-nine participants were studied, divided into three groups: apparently healthy volunteers, those with bacterial infection without sepsis (SOFA score <2), and patients with bacterial sepsis (positive culture and SOFA ≥2). PCT level of each participant was measured and median group levels compared. Pearson’s correlation was used to determine the correlation between serum PCT levels and SOFA scores in the sepsis group using a significance level of 5 percent (P < 0.05). Diagnostic usefulness of PCT was assessed using receiver operating characteristic (ROC).

Result:
Positive correlation was found between serum PCT levels and SOFA scores among patients with sepsis r = 0.42, P = 0.016. At a concentration of ≥4.25 ng/ml, serum PCT as a surrogate for SOFA score had a sensitivity and specificity of 57.60% and 84.80%, respectively, for indicating sepsis. The area under the ROC curve (AUC) was 0.74 (95% CI {0.62 to 0.86}, P = 0.001).

Conclusion:
Serum PCT concentration was significantly higher in bacterial sepsis compared to bacterial infection without sepsis and healthy state. PCT concentration demonstrated positive correlation with SOFA score in bacterial sepsis and can be used as surrogate for sepsis screening/monitoring in resource-poor settings.
Outcome of Transurethral Resection of the Prostate (TURP) using 5% Dextrose Water as Irrigant
Authors: Amu OC , Affusim EA , Nnadozie UU , Nwachukwu CD 
Published: October 2023

ABSTRACT

Background:
TURP remains the gold standard for simple prostatectomy presently. Different fluids have been used for irrigation while performing monopolar TURP. The choice of irrigation fluid depends on a lot of factors.

Aim:
We sought to find out if the outcome of monopolar TURP using 5% dextrose water in our setting compares with findings in other studies using different fluids as irrigation fluid in monopolar TURP.

Materials and Methods:
This was a prospective study of 220 patients who had monopolar TURP using 5% dextrose water as irrigation fluid from 2015 to 2020.

Results:
The study was completed by 220 patients. The mean age was 66.25 yrs. The mean weight of prostate was 53.2 g, and mean resected weight was 30.10 g using a mean irrigation volume of 45.35 liters, 5% dextrose water over a mean resection time of 66.08 mins. The mean changes in International Prostate Symptom Score/quality of life score (IPSS/QOLS) were statistically significant. Early complications recorded were postoperative hematuria with clot retention (1.4%), urinary tract infection (UTI) (13.2%), and secondary hemorrhage (10%). TURP syndrome was not recorded. Late complications seen within 2 years follow-up were transient urinary incontinence (6.4%), urethral stricture (4.1%), and bladder neck contracture (2.3%). There was no repeat TURP for residual adenoma within this period.

Conclusion:
TURP using 5% dextrose water has comparable outcomes to other irrigation fluids for monopolar TURP. It is a good alternative to any other irrigation fluid.
Comparison of the Translucency Parameters and Bond Strength of 5Y-ZP Zirconia, 3-YTZP Zirconia, and Lithium Disilicate
Authors: Ozkan Adak I , Aguloglu S , Adak BM , Sari I 
Published: October 2023

ABSTRACT

Background:
E-max is a more aesthetic material than traditional zirconia. In addition, the bond strength of traditional zirconia with adhesive cements is lower. There are not enough studies on how the aesthetic values and bond strength of 5-YZP, the new generation zirconia, compare to e-max and traditional zirconia. Can 5-YZP be an alternative to e-max in terms of aesthetics and bond strength?

Aim:
The aim of the study is to compare the translucency property and bonding ability of 5y-zp zirconias with previous generation zirconias and lithium disilicate.

Materials and Methods:
Two types of zirconia Katana UT and Katana HT for measuring translucency values; and using a type of lithium disilicate IPS e.max CAD LT, three groups were formed (n = 10). Translucency specimens were fabricated (n = 10). Their L*a*b* values were measured against a black-and-white background with a spectrophotometer, and DE00 was calculated. To perform micro-shear tests, a cylinder design was made from zirconia and IPS e.max CAD blocks (n = 20). After the samples were aged by thermal cycle, the micro-shear test was applied to specimens cemented to teeth extracted with two different adhesive cement systems.

Results:
According to the results of one-way analysis of variance, a statistically significant difference was found between the translucency parameter (TP) values of the groups. According to Tukey’s honestly significant difference (HSD) multiple comparisons, the values of the three groups are statistically different from each other. Although IPS e.max CAD group has the highest TP values, the Katana HT group has the lowest values.

Conclusion:
5Y-PZ has a TP intermediate to those of 3Y-TZP and lithium disilicate. Long-term bond strength of 3Y-TZP and 5Y-ZP were similar to those of lithium disilicate. To be an alternative to glass ceramics in the anterior region, translucency and bond strength values need to be improved.
Impact of the COVID pandemic on functioning of the institutional ethics committee: A comparison study
Authors: Shetty Yashashri Chandrakant , Thatte Urmila Mukund , Pal Amitrajit , Katkar Janhavi 
Published: October 2023

Abstract

Purpose and Aim:
In COVID 19 pandemic, it was essential to document the functioning of the institutional ethics committee (IEC), how the organization adapted and faced challenges posed, thus forming the rationale behind this particular audit. The objectives were to assess the impact of the pandemic on the structure, review process, outcomes, and administration of IEC and to compare the same during its functioning in the prepandemic stage.

Subject and Methods:
The study was conducted as a retrospective audit. After exemption from ethics review, the data were collected from the IEC office situated in KEM Hospital and were segregated into four domains: structure, review process, outcomes, and administration. The data were analyzed using descriptive statistics. Mann–Whitney U-test was used to compare the turnover time for approval of projects between the two study periods at 5% level of significance. SPSS software version 22 was used to analyze the data.

Results:
Constitution changed, more protocols pertaining to COVID 19 studies were reviewed, meetings frequency doubled, and Standard Operating Procedures was amended to incorporate the changes faced during pandemic. Significant decrease in turnover time was noticed with respect to submission to query letter and study completion. There were more protocol deviations. Financial burden and expenditure decreased due to less paperwork and meetings being held online.

Conclusion
The ethics committee infrastructure and functioning had to undergo a paradigm shift to adapt to the various changes and overcome the various hurdles occurring during the COVID-19 pandemic.
Reinforced Hybrid Graph Transformer for Medical Recommendations
Authors: Turukmane Anil V , Pande Sagar , Bedekar Vaidehi , Kadam Aditya 
Published: October 2023

An enormous amount of heterogeneous Textual Medical Knowledge (TMK), which is crucial to healthcare information systems, has been produced by the explosion of healthcare information. Existing efforts to incorporate and use textual medical knowledge primarily concentrate on setting up simple links and pay less attention to creating computers comprehend information accurately and rapidly. Self-diagnostic symptom checkers and clinical decision support systems have seen a significant rise in demand in recent years. Existing systems rely on knowledge bases that are either automatically generated using straightforward paired statistics or manually constructed through a time-consuming procedure. The study explored process to learn textual data, linking disease and symptoms from web-based documents. Medical concepts were scrapped and collected from different web-based sources. The research aims to generate a disease- symptom-diagnosis knowledge graph (DSDKG), with the help of web-based documents. Moreover, the knowledge graph is fed in to Graph neural network with Attention Mechanism (GAT) for learning the nodes and edges relationships. . Lastly Generative Pretrained Transformer 2 (GPT2) all enclosed in a Reinforced learning environment, is used on the trained model to generate text based recommendations.
A new way to tackle a conjecture of Rémond
Authors: Plessis Arnaud 
Published: October 2023

AbstractLet
$\Gamma \subset \overline {\mathbb {Q}}^*$
be a finitely generated subgroup. Denote by
$\Gamma _{\mathrm {div}}$
its division group. A recent conjecture due to Rémond, related to the Zilber–Pink conjecture, predicts that the absolute logarithmic Weil height of an element of
$\mathbb {Q}(\Gamma _{\mathrm {div}})^*\backslash \Gamma _{\mathrm {div}}$
is bounded from below by a positive constant depending only on
$\Gamma $
. In this paper, we propose a new way to tackle this problem.
CONOCIMIENTOS, ACTITUDES, PRÁCTICAS ALIMENTARIAS Y ESTADO NUTRICIONAL EN EMBARAZADAS, REVISIÓN BIBLIOGRÁFICA
Authors: Vásquez Quishpe Evelyn Tatiana , Guanga Lara Verónica Elizabeth 
Published: October 2023

Introducción: según la Organización Mundial de la Salud el equilibrio bio-psico-social, que define a la salud de la mujer gestante debe ser acompañado de una alimentación suficiente, de calidad y poseer conocimiento sobre los elementos de un estilo de vida saludable tanto antes, durante y después del embarazo. Objetivo: Realizar una revisión bibliográfica sobre la relación del conocimiento, actitudes y prácticas alimentarias con el estado nutricional de la embarazada. Metodología: se realizó una revisión bibliográfica basada en información científica actualizada de 57 artículos originales, revisión, estudios de caso, libros, guía de práctica clínica, de base de datos como Pubmed, Web of sciencie, Scielo. Resultados: Los conocimientos, actitudes y prácticas alimentarias que influyen en el estado nutricional de la embrazada son: atención materna, evaluación del estado nutricional, ganancia de peso, requerimiento y suplementación de micronutrientes, consejería nutricional con énfasis en lactancia materna y prácticas integral del parto, inmunización, fortalecimiento del microbiota. Conclusión: Los conocimientos, actitudes y prácticas alimentarias influyen en el estado nutricional de la embarazada y su futuro niño, estan determinadas por una adecuada educación alimentaria y consejería nutricional lo cual nos ayuda a saber sus beneficios, tener buena actitud y practicarlas, manteniendo la salud materna y del niño, evitando complicaciones a corto, mediano y largo plazo.
USO DE ASPIRINA E INHIBIDORES DE P2Y 12 EN PACIENTES CON ENFERMEDAD CARDIOVASCULAR ATEROESCLERÓTICA (ECVA)
Authors: Montero López Izaida Lis , Castillo López Wardy , Díaz Montero Adrián Ernesto , Valdés Cabodevilla Regla Cristina 
Published: October 2023

Introducción: La enfermedad cardiovascular aterosclerótica (ECVA) constituye un trastorno crónico y progresivo que afecta al corazón y arterias de mediano y gran calibre como consecuencia de la ateroesclerosis, siendo sus formas de presentación más frecuentes la cardiopatía isquémica y la enfermedad cerebrovascular. Fármacos como los antiagregantes plaquetarios, aspirina e inhibidores de P2Y 12, son utilizados para prevención primaria y secundaria de la ECVA. Objetivo: Analizar la eficacia de la aspirina e inhibidores de P2Y 12 en pacientes con enfermedad cardiovascular ateroesclerótica. Metodología: se realizó una revisión bibliográfica sobre el uso de aspirina e inhibidores de P2Y12 en la ECVA, para lo cual se usaron ensayos que se eligieron de acuerdo a criterios de inclusión y exclusión. Resultados: se encontraron 6 estudios originales que comparan o exponen la eficacia de la aspirina e inhibidores de P2Y12. Discusión: Los estudios demuestran que la aspirina sigue siendo el fármaco de elección en la prevención secundaria y el tratamiento de ECVA. Los inhibidores de la P2Y12 también han reportado beneficio, los más documentados son el clopidogrel y ticagrelor. Conclusiones: El uso de aspirina e inhibidores de P2Y12 como terapia para la prevención primaria de ECVA, actualmente tiene poca evidencia de su beneficio, sin embargo, para la terapia de prevención secundaria está bien documentada y su mejor efecto se observa al combinarse con inhibidores de P2Y12.