bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indifférenciation et perte mélancolique d’objet chez une jeune jumelle
Authors: Houssier Florian , Pheulpin Marie-Christine , Prigent Adam , Ikiz Simruy , Haidar Haya , Vibert Sarah 
Published: November 2023

À partir d’une séance de consultation unique avec une jeune femme évoquant son frère jumeau, les auteurs soulignent les entraves notamment mélancoliques du travail de séparation dans le contexte de la fin d’adolescence, ouvrant sur un dégagement vis-à-vis des objets d’amour primaire. Ce mouvement d’ensemble est souvent nommé sommairement « séparation » ; nous interrogeons par rebond le sens de ce terme, utilisé comme un mot bouchon amenant l’illusion d’une compréhension commune, immédiate et précise, pour lui substituer l’expression de différenciation/personnalisation.
La France ne pourra atteindre ses objectifs climatiques qu’avec une planification ambitieuse et concertée
Authors: Stokking Emma 
Published: November 2023

Le think tank The Shift Project a publié début 2022 son « Plan de transformation de l’économie française 1 », un vaste programme qui vise à décarboner l’économie, secteur par secteur durant le quinquennat 2022-2027, en favorisant la résilience et l’emploi. Plus d’un an après sa publication, le diagnostic qu’il dresse et les propositions qu’il présente restent adaptés face aux crises climatiques et énergétiques actuelles.
Réchauffement du permafrost dans les Alpes occidentales: une nouvelle preuve d’un réchauffement qui dépend de l’altitude?
Authors: Pogliotti Paolo , Cremonese Edoardo , Cella Umberto Morra di 
Published: November 2023

La présente étude vise à caractériser l’évolution thermique récente du permafrost dans la région de la Vallée d’Aoste (Italie, Alpes européennes occidentales) en utilisant comme indicateurs les anomalies d’épaisseur de la couche active et les tendances au réchauffement des températures de subsurface et en profondeur. L’ensemble des données comprend des sites d’étude situés à différentes altitudes et dans des contextes géomorphologiques variés tels que des parois rocheuses, des plateaux de haute altitude, et des marges proglaciaires.Les résultats montrent que l’épaisseur de la couche active augmente partout et que les anomalies sont cohérentes entre les sites malgré leurs caractéristiques et distances. Des tendances significatives au réchauffement d’environ +0,2 °C/10 ans sont observées à 15 m de profondeur dans des sites situés autour de 3000 m d’altitude. Dans les parois rocheuses, les tendances au réchauffement à la surface de la roche ne sont significatives que sur les versants nord où les valeurs sont en moyenne de +0,42 °C/10 ans à des altitudes supérieures à 4000 m.La présente étude fournit également un aperçu de l’évolution thermique actuelle du permafrost dans les Alpes du nord-ouest ainsi que des informations cohérentes et utiles pour la gestion des risques. Profitant de cette analyse, l’étude vise également à souligner que les mesures de température dans le permafrost pourraient contribuer au débat sur la dépendance du réchauffement à l’altitude.
Tree-ring Dating of the Little Ice Age Maxima of Arolla Glaciers (Valais, Switzerland)
Authors: Le Roy Melaine , Nicolussi Kurt , Schlüchter Christian 
Published: November 2023

Little Ice Age (LIA) glacier variations are well constrained in the Alps, partly thanks to an unparalleled body of historical sources. When absent, tree-ring dating can be used to obtain accurate chronological information on glacier maxima. To do so, it is necessary to focus on the trees that immediately bordered the former maximum extent reached by the glaciers in historical times. Here, we present tree-ring dating results for newly sampled wood material and archival data from the forefields of two glaciers in the Pennine Alps, Tsijiore Nouve and Glacier d’Arolla. These sites have historical sources dating back to the early 19th century, i.e. slightly more recent than for the best known Alpine glaciers. At Tsijiore Nouve, the dating of trees embedded in the LIA outer moraine at the valley bottom and of bordering living trees both indicate the presence of the ice near this location as early as summer 1813 CE and of a maximum extent reached in 1816 CE. This is highly consistent with available historical sources pointing to a LIA maximum in 1817 CE. At Glacier d’Arolla we dated the outermost moraine to winter 1816/1817 CE, which is synchronous, despite different glacier response times. The dates we obtained are significantly earlier than available evidence at other Alpine glaciers during the same advance. Our results highlight the ability of tree-ring dating to derive accurate calendar dates for glacier maxima and show – for the first time in the Alps - that some glaciers were already at or near their LIA maxima when the cooling associated with the Mount Tambora volcanic eruption occurred.
Flexible Thinking Value-Add: Embedding Strategic Design into Graduate Education
Authors: Eze Kingsley , Quayle Moura 
Published: November 2023

This article shares experiences of embedding strategic design into graduate education including learners’ feedback, and focus group outcomes. The goal of policy education in graduate school is to engage and inspire learners to critically think and problem-solve. Modern-day problems continuously challenge the status quo of conventional thinking and require a unique approach to tackling them. Strategic design, as a model, provides a framework to tackle challenging issues across multiple sectors by applying the ASK, TRY, and DO approach. It is anticipated that the learnings of this study inspire more educators to adopt and incorporate strategic design into their curriculum. In addition, educators could embed these findings into their learning environments as part of the quest for innovation in Public Policy and Interdisciplinary Studies.
A Boy with End-stage Kidney Disease and Hypertriglyceridemia
Authors: Raina Manan , Savita S , Singh Kanika , Sethi Sidharth K. 
Published: November 2023

Abstract
Mutations in the HNF-1β gene have been found to be associated with renal cysts and diabetes syndrome (RCAD), also known as MODY5. The mutation is inherited in an autosomal dominant fashion, although sporadic mutations can be seen. Pediatric cases of HNF - 1β mutations are more likely to present with renal involvement like renal failure or renal hypoplasia. In young individuals, the detection of renal abnormalities usually pre-date the diagnosis of diabetes with a mean age of 24 years. We report a 5 year old, end stage kidney disease patient with renal cysts and hypertriglyceridemia (in the absence of overt diabetes) with a known pathogenic mutation in the Hepatocyte Nuclear Factor-1β (HNF-1β) gene on chromosome 17q12. This case expands the clinical spectrum of HNF-1β mutation disorders with a take home message, that end stage renal disease patients with unexplained hypertriglyceridemia (even in absence of diabetes mellitus) should alert a clinician for HNF-1β mutational analysis.
Bedside Method to Check the Adequacy of Kidney Biopsy Sample with a Smartphone Camera and Macro Lenses: A Prospective Cohort Study
Authors: Modi Suny S. , Ramamurthy Satheesh , Balasubramanian S. , Kumar Sunil , Daruwala Feral 
Published: November 2023

Abstract

Introduction:
The utilization of smartphone-assisted evaluation is emerging in the field of histopathology. This technique improves the adequacy of samples at the bedside, avoids procedure-related complications, reduces unnecessary repeat biopsies, and saves the cost of the procedure. This study aims to compare the number of glomeruli in a renal biopsy specimen obtained by an ultrasound-guided percutaneous needle biopsy, counted at the bedside using a smartphone fitted with a 16-megapixel macro lens (Bedside method) with that observed under a light microscope after the processing of the biopsy specimen (LM method).

Methods:
In this prospective cohort study, 24 consecutive adult patients (48 kidney biopsy samples) who underwent kidney biopsies were enrolled. All specimens were extracted by an ultrasound-guided percutaneous renal biopsy from the lower pole of the left kidney. Patients’ demographics and clinical data were prospectively collected. The number of glomeruli in all the biopsy specimens was counted using a smartphone fitted with a 16-megapixel macro lens at the bedside (Bedside method) and subsequently under a light microscope by a pathologist after processing the biopsy specimen (LM method). Seven or more glomeruli in the specimen were considered adequate in our study.

Results:
The mean age of patients at biopsy was 46.9 ± 16 years with slightly male predominance (54.2%). A total of 47 specimens were obtained from 24 patients. Of the 24 patients, 22 had native kidney biopsy and 2 had renal allograft biopsy. The average number of cores obtained per patient was 1.96. The length of core specimens ranged from 1.5 to 2 cm. A good agreement was found between bedside adequacy and slide adequacy, κ =0.684, P = 0.000. The positive agreement rate and negative agreement rate were 91.4% and 23.1%, respectively.

Conclusion:
In the modern era of technology, the smartphone is a good tool to evaluate the adequacy of biopsy specimens at the bedside.
Perceptible Experiences of General Population: Lesson Learnt Across First and Second Wave of Pandemic
Authors: Sharma Rajni , Kumar Krishan , Tyagi Pooja , Suri Vikas , Dhiman Deepanshu , Saini Lokesh , Yadav Jaivinder , Sharma Divyansh , Ghai Babita 
Published: November 2023

Introduction:
Lockdown during the initial wave of the COVID-19 pandemic and isolation were discovered to have a negative psychological influence on the general population’s mental health and wellbeing.

Aim:
This study aims to Trace and compares the impact of the COVID-19 pandemic on mental health in terms of psychological well-being (PWB), distress and family functioning during the first and second wave.

Materials and Methods:
A convenient purposive sampling method was used to conduct an online survey during the first COVID wave (May 2020–July 2020) in India, and the same demographic group was re-contacted (March 2021–May 2021) during the second wave. The institute ethical committee was consulted in advance for approval, and participants’ digital consent was obtained. The first and second waves of the COVID-19 epidemic in India were evaluated using the PWB scale, the depression anxiety stress scale 21, and the brief family relationship scale.

Results:
Among all individuals, there was a 25.4%, 39.3%, and 30% prevalence of stress, anxiety, and depression, respectively in our study. Participant’s well-being and family relationships were negatively impacted by anxiety and depression. Older participants reported more favorable relationships and higher levels of well-being than younger participants did. Women scored significantly lower on psychological well-being measures and much higher on stress, anxiety, and depression measures than men.

Conclusion:
The first wave, which has contributed to a significant increase in psychiatric morbidity, affected the general population at a moderate intensity. The present study’s findings may be useful for developing policies, intervention programs, and offering psychosocial help to the community.
Septic Shock
Authors: Malvel Sindhu , Chandrashekar Supraja , Singh Rajesh Kumar 
Published: November 2023

Background:
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, potentially life-threatening, drug-induced hypersensitivity reaction that includes skin eruption, hematologic abnormalities, lymphadenopathy, and internal organ involvement.

Clinical Description:
An 11-year-old boy presented with high-grade intermittent fever and generalized rash for 7 days. He was started on phenytoin 1 month back. On presentation, the child was sick looking with 104°F fever, tachypnea, tachycardia, flushed with bounding pulses, and generalized edema suggestive of septic shock. Distinct diffuse erythematous, maculopapular rash with normal mucosae was noted all over the body with palmar and plantar erythema associated with hepatomegaly and ascites. Investigations showed eosinophilia.

Management:
The child was managed conservatively for septic shock, followed by withdrawing phenytoin and giving a pulse dose of methylprednisolone, followed by oral prednisolone.

Conclusion:
In children presenting with prolonged fever and rash with septic shock, DRESS syndrome should be considered differential diagnosis. A strong clinical suspicion and appropriate lab investigations is cornerstone of diagnosis.
Novel Heterozygous Mutation of CIITA Gene Presenting with Recurrent Infections and Systemic Lupus Erythematosus
Authors: Chidambaram Aakash Chandran , Ramamoorthy Jaikumar Govindaswamy , Krishnamurthy Sriram , Manivannan Prabhu , Karunakar Pediredla 
Published: November 2023

Background:
The expression of major histocompatibility complex (MHC) molecule is essential for homeostasis of the immune system. The expression of MHC-II is regulated by the master regulator for transcription, the Class II transactivator (CIITA) gene. Homozygous mutations affecting the CIITA gene result in bare lymphocyte syndrome type-II, but the clinical manifestations of heterozygous mutations are not well reported.

Clinical Description:
Herein, we describe the roller coaster course of a 6-year-old child who had presented with recurrent infections in infancy and systemic lupus erythematosus (SLE) in toddler age, who was later found to have heterozygous mutation in the CIITA gene.

Management:
The child was managed with immunosuppression for SLE and monthly intravenous immunoglobulin replacement therapy and daily cotrimoxazole prophylaxis for features of immunodeficiency.

Conclusion:
This case report aims to provide more insight into the clinical features associated with heterozygous mutations of CIITA.
Neonatal Osteosclerotic Bone Dysplasia (Raine Syndrome)
Authors: Girigiri Tarun Kumar , Reddy Tejaswi , Madireddy Alimelu , Lingaldinna Swapna 
Published: November 2023

Background:
Raine syndrome is a rare autosomal recessive neonatal osteosclerotic bone dysplasia caused due to mutations in the FAM20C gene. It has an early and aggressive onset which often results in death in the first few weeks of life, although there have been cases of patients surviving into childhood.

Clinical Description:
We describe the case of a neonate girl born with microcephaly, proptosis, triangular mouth, depressed flat nasal bridge, mid-face hypoplasia, low set ears, high-arched palate, and a wide-open anterior fontanelle. Based on the clinical phenotype, the differentials considered were a congenital infection and Crouzon syndrome.

Management:
Infantogram revealed generalized osteosclerosis. Based on the radiological phenotype, the differentials considered include Thanatophoric dysplasia, osteopetrosis, and Achondroplasia. Search for concealed anomalies revealed dysmorphic features in the brain and kidneys. The clinical exome demonstrated a heterozygous missense and heterozygous nonsense variant in exon-7 of the FAM20C gene, which established the diagnosis of Raine syndrome.

Conclusion:
Genetic analysis based on phenotype can aid in the early diagnosis of dysmorphic children and help in instituting appropriate management
Atypical Mongolian Spots in an Infant
Authors: Gadhiraju Manisha Varma , Manugu Navya Sree , Etikela Sangeetha , Kodandapani Yerroju 
Published: November 2023

Background:
Atypical Mongolian spots are lesions that are aberrant in location (over the abdomen, back, legs, shoulders, or arms), extensive in distribution, persist beyond early infancy, and/or progressively increase in number. These are frequently associated with lysosomal storage disorders or neurocristopathies.

Clinical Description:
A 4-month-old girl presented with a common cold. Extensive aberrant Mongolian spots over the back, buttocks, lower limbs, and new onset grayish-blue macular spots over the abdomen prompted us to do a detailed evaluation to look for any underlying pathology. Other salient clinical findings included coarse facies, hepatomegaly, absence of significant developmental delay, bilateral macular cherry red spots, and ovoid-shaped vertebral bodies. The clinical phenotype was that of a lysosomal storage disorder possibly GM1 gangliosidosis. This was confirmed by deficient levels of ß-galactosidase.

Management:
The parents underwent genetic counseling. The infant was enrolled in an early intervention program. By the age of 6 months, the infant had not acquired any new developmental skills and new Mongolian spots did not develop. Subsequently, the family was lost to follow-up.

Conclusion:
Infants with aberrant Mongolian spots need to undergo an in-depth evaluation to identify underlying systemic disorders, even if they are asymptomatic. Diagnosis helps in providing supportive care to the child, specific therapy (if available) and the option of prenatal diagnosis in subsequent pregnancies.
Bell's Palsy in a Child with Acute Viral Hepatitis C Infection
Authors: Thakur Neha , Rai Narendra 
Published: November 2023

Background:
Bell's palsy is the most common form of facial paralysis in children. Etiology of facial paralysis can be both congenital and acquired. Acquired facial paralysis in most cases is due to viral infections. Hepatitis C infection leading to Bell's palsy is an unusual complication which has not been reported until now.

Clinical Description and Management:
A 4 month's old male child was admitted with fever, vomiting, refusal to feed, and icterus. His investigations revealed anemia with neutrophilic leukocytosis and deranged liver function tests. Hepatitis C antibody test was reactive. On 5th day of admission, right-sided Bell's palsy was noticed. There were no other signs of neurological deficit. Parental testing revealed hepatitis C antibodies in mother. The child was managed conservatively. He responded to treatment and symptoms subsided within 1 week of its onset.

Conclusion:
This case report highlights an unusual complication of hepatitis C infection in children. Prognosis in this case was good as the child recovered spontaneously.
Role of Virtual Psychosocial Interventions in Coping with Mental Health Challenges of Children during the Pandemic
Authors: Bharti Bhavneet , Malhi Prahbhjot 
Published: November 2023

Background:
The morbidity and mortality rates associated with the COVID-19 infection among children, fortunately, continue to be low; nevertheless, children are experiencing several pandemic-related mental health risks.

Clinical Description:
DK, a 9-year-old boy, was referred to the pediatrics department of a tertiary care center for compulsive oxygen saturation checking behaviors that developed a few weeks after the sudden demise of his maternal grandfather due to the COVID-19 infection. A diagnosis of adjustment disorder with emotional and behavioral problems was made as per the Diagnostic and Statistical Manual of Mental Disorder-5 criteria.

Management:
A comprehensive management plan was drawn out that focused on encouraging the parents to engage in productive and meaningful conversations regarding death being a permanent event in the life cycle. The child was asked to draw so that he could share his feelings and was also taught “belly breathing” that used a script of 4 counts in and 4 counts out by sharing child-orientated educational videos. The family was asked to chalk out a structured routine with time for creative artwork besides completing academic assignments. Follow-up after a month of therapy revealed an overall improvement in behavior, increased interactions with teachers and peers, and decline in compulsive checking of oxygen saturation levels.

Conclusions:
There is a need to expand digital treatment options for children, especially during times of public health emergencies, by using online psychoeducation resources, mental health apps, and conducting online therapy sessions.
Analisis Neraca Perdagangan Indonesia: Pendekatan ARDL
Authors: Faudzi Maman , Asmara Gea Dwi 
Published: November 2023

Abstrak: Penelitian ini dilakukan untuk mengetahui pengaruh serta hubungan antar variabel Kurs, Jumlah Uang Beredar (M2), Inflasi, dan Cadangan Devisa terhadap Neraca Perdagangan Indonesia tahun 1986-2021. Data yang digunakan dalam penelitian ini adalah data time series dalam bentuk tahunan yang didapat dari web resmi World Bank dan Bank Indonesia (BI). Penelitian ini dibangun dengan model Autoregressive Distributed Lag (ARDL) dan diolah menggunakan software Eviews10. Dengan menggunakan Maximum Lag sebesar 2. Dari hasil olah data yang dilakukan menunjukkan bahwa dalam jangka pendek semua variabel berpengaruh secara signifikan terhadap neraca perdagangan, sedangkan dalam jangka panjang semua variabel berpengaruh secara signifikan kecuali variabel inflasi. Nilai R-square pada model ARDL yang dibentuk menunjukkan sebesar 85% memiliki korelasi yang dapat dijelaskan dalam model, sedangkan sebesar 15% dijelaskan oleh variabel di luar model.

Abstract: between Kurs, Broad Money (M2), Inflation, and Exchange Reserve to Indonesia’s Trade Balance on 1986-2021. The data used in this research is time series in annual which from official website of World Bank and Bank Indonesia (BI). The study was built with an Autoregressive Distributed Lag (ARDL) and processed with Eviews10 software. Using a maximum lag of two. The results of data processing found that that all variables in the model have a significant effect in short-term to trade balance, whereas in long-term all variables have a significant effect unless inflation. R-square values in ARDL model show that 85% of the correlation described in models, whereas 15% is explained by variables outside of models.
Impact of Temperature on Insect Behavior in India
Authors: Bharata Arrian 
Published: November 2023

Purpose: The aim of the study was to investigate the Impact of Temperature on Insect Behavior in India.
Methodology: The study adopted a desktop methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library
Findings: Research on the impact of temperature on insect behavior in India has demonstrated significant findings. As temperatures continue to rise due to climate change, insects are exhibiting altered behaviors, affecting various ecosystems and agricultural practices. Studies indicate shifts in the timing of insect life cycles, including altered breeding patterns and earlier emergence from diapause. Additionally, rising temperatures have been associated with increased insect pest activity, posing threats to crop yields and ecosystem dynamics. These findings underscore the need for proactive measures to mitigate the consequences of changing insect behaviors in India, including adaptive agricultural strategies and ecosystem management practices.
Unique Contribution to Theory, Practice and Policy: The Degree-Day Theory, Temperature-Dependent Activity Theory and Optimal Foraging Theory may be used to anchor future studies on the Impact of Temperature on Insect Behavior in India. Pest control strategies should be tailored to account for temperature-dependent shifts in insect activity patterns, thereby optimizing the timing and choice of control measures. Policymakers should recognize the critical role of temperature in shaping insect behavior and its cascading effects on ecosystems, food security, and public health.
Keywords: Temperature, Insect, Behavior
©2023 by the Authors. This Article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0