bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term results of corrective surgical interventions in patients with diabetic midfoot neuroosteoarthropathy
Authors: Kalandiya M. M. , Doronina L. P. , Mitish V. A. , Tokmakova A. Yu. , Zaitseva E. L. , Galstyan G. R. 
Published: November 2023

BACKGROUND: Diabetic neuroosteoarthropathy is a disabling complication of diabetes mellitus that develops as a result of impaired peripheral innervation and characterized by damage to bones and joints of non-infectious origin. As a result of pathological bone fractures, gross deformities of the foot are formed, which entails development of chronic ulcerative defects in areas of excessive load pressure. Currently, a number of surgical interventions are used to correct deformities, such as resection of bone structures, correction with metal structures and external fixation devices, but there is practically no data on their long-term results in the domestic literature.AIM: To study the results of orthopedic corrective interventions in patients with diabetes mellitus and midfoot neuroosteoarthropathy.MATERIALS AND METHODS: An analysis was made the data collected by questionnaire method of 55 patients operated in the diabetic foot department in the Endocrinology research centre from 2009-2019. All patients underwent a reconstructive operation aimed correcting a gross deformity of the midfoot. In postoperative period, the affected limb was off-loaded by total contact cast for a period of 3-6 months, and in the future, complex orthopedic shoes for permanent use and regular podiatric care were recommended to patients.RESULTS: After the first surgical intervention, 16 patients developed a recurrence of deformity, which required a second surgical intervention. The median period between interventions was 3 years. Chronic wounds of various localization of the operated foot were found in 25 patients.The median period between surgery and ulcer formation was 5 years. 9 patients with chronic wounds underwent minor amputations at the same foot. Amputations on the contralateral limb were performed in 7 patients. None of the patients underwent major amputations.CONCLUSION: Charcot foot is a severe complication of diabetes mellitus that can lead to loss of a lower limb. Due to results of the research orthopedic corrections of the midfoot deformities in patients with DNOAP can reduce the risk of ulcer developement and possible major amputations. Active monitoring and adequate orthopedic care in the postoperative period significantly reduce the risk of deformity recurrence and the need for repeated surgical interventions.
M-index as a predictor of glycemia normalization in T2D patients early after bariatric surgery
Authors: Shestakova E. A. , Sklyanik I. A. , Panevina A. S. , Yurasov A. V. , Yashkov Yu. I. , Sineokaya M. S. , Gavrilova A. O. , Evdoshenko V. V. , Fedenko V. V. , Bordan N. S. , Shestakova M. V. 
Published: November 2023

There are several models for predicting remission of type 2 diabetes mellitus (T2D) a year after bariatric surgery — DiaRem, ABSD, IMS, etc. However, these models cannot be used to predict the early normalization of glycemia (within a few months after surgery). These models also do not include the assessment of insulin resistance (IR).AIM. To assess the effect of insulin resistance on the development of remission of T2D after bariatric surgery.METHODS: The study included 42 patients with T2D and severe obesity, who underwent bariatric surgery. Baseline assessment included hyperinsulinemic euglycemic clamp test (with the determination of the M-index (mg/kg/min), and evaluation of HOMA-IR index. Glycemia normalization was determined by self-monitoring (<6.1 mmol/l at fasting state and <7.8 mmol/l 2 hours after meals) as well as by HbA1c (<6.5%, starting 3 months after surgery). We used ROC analysis to determine the possibility of using IR indicators in predicting of the normalization of glycemia after bariatric surgery. The cut off value was determined using the Yuden criterion.RESULTS: All patients were severely insulin resistant. The median M-index before surgery was 1.535 mg/kg/min, the HO-MA-IR index was 10.0. During 1 year after surgery the increasing number of patients reached normal glycemia: 7 (16.7%) patients in 1 month, 22 (52.4%) patients after 3 months, 31 (73.8%) patients after 6 months, 35 (83.3%) patients after 12 months. In ROC analysis the optimal threshold the M-index was 1.876 mg/kg/min.CONCLUSION: The value of the M-index > 1.876 mg/kg/min can be used to predict the glycemia normalization early after bariatric surgery.
Machine learning methods in the differential diagnosis of difficult-to-classify types of diabetes mellitus
Authors: Rusyaeva N. V. , Golodnikov I. I. , Kononenko I. V. , Nikonova T. V. , Shestakova M. V. 
Published: November 2023

The course of difficult-to-classify types of diabetes mellitus (DM) (slowly developing immune-mediated DM of adults (LADA), monogenic forms of DM (MODY)) has common features with both type 1 DM (T1DM) and type 2 DM (T2DM), so often remain misdiagnosed. Errors in determining the type of diabetes lead to incorrect treatment tactics, which leads to poor glycemic control, the development of complications, a decrease in the patient's quality of life, and increased mortality.The key method for diagnosing MODY is sequencing of genes associated with this disease, and LADA is an immunological blood test in combination with the features of the clinical picture. However, the exact criteria for referring patients to these studies have not yet been determined. Performing these studies on all patients without exception with risk factors can lead to unjustified economic costs, and access to them is often difficult. In this regard, various automated algorithms have been developed based on statistical methods and machine learning (deep neural networks, “decision trees”, etc.) to identify patients for whom an in-depth examination is most justified. Among them are algorithms for the differential diagnosis of T1DM and T2DM, algorithms specializing in the diagnosis of only LADA or only MODY, only one algorithm is aimed at multiclass classification of patients with diabetes. One of the algorithms is widely used, aimed at diagnosing MODY in patients under the age of 35 years. However, existing algorithms have a number of disadvantages, such as: small sample size, exclusion of patients with MODY or older patients from the study, lack of verification of the diagnosis using appropriate studies, and the use of late complications of diabetes as parameters for diagnosis. Often the research team did not include practicing physicians. In addition, none of the algorithms are publicly available and have not been tested for patients in Russia. This manuscript presents an analysis of the main automated algorithms for the differential diagnosis of diabetes, developed in recent years.
Impact of the new European medical device regulation: a two-year comparison
Authors: Carl Ann-Kathrin , Hochmann David 
Published: November 2023

Abstract

Objectives
In recent years, the European Union has revised its regulatory framework for medical devices, primarily to improve patient safety and public health. The Medical Device Regulation (MDR) is fully applicable since May 2021, strengthening the requirements for all stakeholders. As a result, many companies are facing enormous challenges. The aim of this study was to assess the impact of the MDR on the orthopaedic aids industry.

Methods
Two surveys were conducted: one shortly before the MDR became applicable (146 respondents) and a second survey almost two years later (233 respondents).

Results
Both surveys revealed that all businesses in the orthopaedic aids sector, regardless of size, have difficulty implementing the MDR. Key challenges include additional workload for technical documentation, increased resource expenditure and cost, and lack of clarity regarding the new requirements. Many companies are downsizing their product portfolio, resulting in potential supply shortages and a loss of competitive advantage and innovation for the medical device industry in Europe.

Conclusions
The full extent of the MDR’s impact on clinical practice is still unclear. However, many companies lack the necessary resources. The MDR can potentially be a bottleneck in the availability of medical devices.
Perinatal supplementation with selenium nanoparticles modified with ascorbic acid improves hepatotoxicity in rat gestational diabetes
Authors: Rady Ahmed M. , Ebaid Hossam , Habila Mohamed , Hassan Iftekhar , Al-Tamimi Jameel , Alhazza Ibrahim M. , Moshab Mohamed S. , ALOthman Zeid A. 
Published: November 2023

Abstract
Because of the potential bioactivities, nanoparticles have engendered hope in scientific communities for developing novel therapeutic strategies. In the present study, it was tested whether selenium nanoparticles (Se-NPs) can protect the liver in mothers with gestational diabetes (DM). The gestational rats were divided into three groups (n = 8). Group 1 (CN) received the vehicle, Group 2 (DM) received a single intraperitoneal injection of 165 mg/kg of alloxan, and Group 3 (DM + Se-NPs) received a single intraperitoneal injection of 165 mg/kg alloxan and then treated with Se-NPs at a dose of 2.5 mg/kg twice a week for 6 weeks; 1 week before gestation and continued for 5 weeks. The structure of the fabricated Se-NPs modified with ascorbic acid indicated that nano-Se was associated with a carbon matrix. The body weight of diabetic mothers was lower compared to control animals. The use of Se-NPs as a treatment has led to significant restoration of the body weight in diabetic rat mothers compared to those diabetic animals without treatment. Concentrations of alanine transaminase, aspartate aminotransferase, LDH, malondialdehyde, cholesterol, triglycerides, and glucose were significantly increased in diabetic rats, while glutathione significantly declined in comparison to control gestational rats. Interestingly, Se-NPs in DM + Se-NPs rats were found to restore all these parameters to values close to the control levels. Se-NPs could improve the histological structure of the liver in gestational rats with diabetes (DM + Se-NPs). Our data demonstrate that Se-NPs shield the liver structure and function in gestational rats against alloxan-induced diabetes.
Outliers in nutrient intake data for U.S. adults: national health and nutrition examination survey 2017–2018
Authors: Burcham Sara , Liu Yuki , Merianos Ashley L. , Mendy Angelico 
Published: November 2023

AbstractObjectivesAn important step in preparing data for statistical analysis is outlier detection and removal, yet no gold standard exists in current literature. The objective of this study is to identify the ideal decision test using the National Health and Nutrition Examination Survey (NHANES) 2017–2018 dietary data.MethodsWe conducted a secondary analysis of NHANES 24-h dietary recalls, considering the survey's multi-stage cluster design. Six outlier detection and removal strategies were assessed by evaluating the decision tests' impact on the Pearson's correlation coefficient among macronutrients. Furthermore, we assessed changes in the effect size estimates based on pre-defined sample sizes. The data were collected as part of the 2017–2018 24-h dietary recall among adult participants (N=4,893).ResultsEffect estimate changes for macronutrients varied from 6.5 % for protein to 39.3 % for alcohol across all decision tests. The largest proportion of outliers removed was 4.0 % in the large sample size, for the decision test, >2 standard deviations from the mean. The smallest sample size, particularly for alcohol analysis, was most affected by the six decision tests when compared to no decision test.ConclusionsThis study, the first to use 2017–2018 NHANES dietary data for outlier evaluation, emphasizes the importance of selecting an appropriate decision test considering factors such as statistical power, sample size, normality assumptions, the proportion of data removed, effect estimate changes, and the consistency of estimates across sample sizes. We recommend the use of non-parametric tests for non-normally distributed variables of interest.
Research Supervision as a Spiritual Ministry: A Confluence of Object Relations, Psychodynamics and Grace
Authors: Pugh Jeffrey Raymond 
Published: November 2023

Abstract
The changes in the pedagogy of research supervision in the university context are now reflected within the practices of theological seminaries and accredited colleges. A neglected analytical framework that could illuminate the supervisory relationship is provided by Winnicott’s Object Relations Theory and Bion and Diamond’s Organizational Psychodynamics, as they interconnect identity, stress and creativity – factors that are germane to the researcher experience. Object Relations also parallels faith development. Given the significant personal investment demanded by research, a crisis of identity for the religious student is simultaneously a crisis of faith. Conversely, a Christian faith experience could sustain the research journey through the appropriation of divine Grace. Some suggestions are provided as to how this could be manifested within the research culture.
On the estimation of periodic signals in the diffusion process using a high-frequency scheme
Authors: Pramesti Getut , Saptono Ristu 
Published: November 2023

Abstract
The estimation of the frequency component is very interesting to study, considering its unique nature when these parameters are together in their amplitude.
The periodicity of the frequency components is also thought to affect the convergence of these parameters.
In this paper, we consider the problem of estimating the frequency component of a periodic continuous-time sinusoidal signal.
Under the high-frequency sampling setting, we provide the frequency components’ consistency and asymptotic normality.
It is observed that the convergence rate of the continuous-time sinusoidal signal of the diffusion process is the same as the continuous-time sinusoidal signal of the Ornstein–Uhlenbeck process, which is mentioned in [G. Pramesti, Parameter least-squares estimation for time-inhomogeneous Ornstein–Uhlenbeck process, Monte Carlo Methods Appl.
29 (2023), 1, 1–32].
The result of this study deduces that the convergence rate of the frequency is the same as long as the signal is periodic.
In this case, the existence of the rate of reversion does not affect the convergence rate of the frequency components.
Further, the result of the study, that is, the convergence rate of the frequency is

(

n
⁢
h

)

3

\sqrt{(nh)^{3}}

, also revised the previous one in [G. Pramesti, The least-squares estimator of sinusoidal signal of diffusion process for discrete observations, J. Math. Comput. Sci.
11 (2021), 5, 6433–6443], which mentioned

(

n
⁢
h

)

3

⁢
h

\sqrt{(nh)^{3}h}

.
The proposed approach is demonstrated with a ten-minute sampling rate of real data on the energy consumption of light fixtures in one Belgium household.
Thermodynamics of transamination reactions with aminotrimethylsilanes and diaminodimethylsilanes
Authors: Knerr Steven , Herbig Marcus , Kroke Edwin 
Published: November 2023

Abstract
Transamination reactions of two different aminosilanes (trimethyl(tert-butylamino)silane and dimethyl(diamino)silane) with amines (diethylamine, pyrrolidine, tert-butylamine, iso-propylamine, and n-propylamine) are studied. For trimethyl(organoamino)silanes, the reaction of trimethyl(iso-propylamino)- or trimethyl(diethylamino)silane as aminosilanes and aniline or pyrrolidine are good starting materials to produce trimethyl(anilino)- and trimethyl(pyrrolidino)silane. The investigated equilibrium constants of the reactions of monoaminosilanes show a good correlation with quantum chemically calculated values. The reaction of two different diaminosilanes Me2Si(NR1R2)2 and Me2Si(NR3R4)2 containing different amino moieties leads to the formation of mixed diaminosilanes Me2Si(NR1R2)(NR3R4) in most cases.
Crystal structure of 1-(2,6-dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)-1,2-dihydro-4H-benzo[d][1,3]oxazin-4-one, C19H14Cl2N2O3
Authors: Zhu Zhoujing , Zhang Cuiya , Xu Xiaona , Tang Wenqiang 
Published: November 2023

Abstract
C19H14Cl2N2O3, monoclinic, P21/c (no. 14), a = 10.635(3) Å, b = 8.772(3) Å, c = 19.656(6) Å, β = 98.256(10)°, V = 1814.8(10) Å3, Z = 4, R

gt
(F) = 0.0602, wR

ref
(F
2) = 0.1547, T = 205 K.
Exploring relationships among soundscape perception, spatiotemporal sound characteristics, and personal traits through social media
Authors: Chan Ta-Chien , Wu Bing-Sheng , Lee Yu-Ting , Lee Ping-Hsien , Deng Ren-Hao 
Published: November 2023

Abstract
Understanding the causes of noise annoyance requires recognition of the factors that affect soundscape perceptions. This study aims to explore multilevel factors of acoustic comfort and the perceived health effects of sound exposure, including personal traits, sound characteristics, and spatiotemporal features of the surrounding environment. We designed the Soundmap chatbot to collect data from the participants during May 16-July 16, 2022. The participants completed two tasks including sound recording and questionnaires. Sound feature extraction and identification were computed. Two soundscape perception variables were used as outcome variables and measured, and cumulative link mixed models were applied for statistical analysis. Results showed that for female participants, lower acoustic comfort was associated with sound exposure at night, at the land use of transportation and built-up areas, as well as the sounds of machines, vehicles, and airplanes. Low-frequency sound exposure and sounds of nature, silence, music, and human activity were associated with higher acoustic comfort, and these exposures were also associated with positive perceptions of health in rural areas and on weekends. Individuals with extraversion had a higher tolerance to sound; those with high noise sensitivity had a lower tolerance to sound. Understanding sound perception is crucial in maintaining a sustainable urban acoustic environment.
Supramolecular assemblies with macrocyclic hosts: applications in antibacterial activity
Authors: Koley Suprotim , Gaur Monika , Barooah Nilotpal , Bhasikuttan Achikanath C. , Mohanty Jyotirmayee 
Published: November 2023

Abstract
This review article focuses on the supramolecular assemblies fabricated through host-guest interaction using macrocycles such as cyclodextrins, calixarenes and cucurbiturils as hosts. Though several review articles have appeared on such host-guest assemblies having importance in controlled drug-delivery, fluorescence on-off sensors, catalysis etc., not much attention has been given to collect their potential applications in antibacterial activity. In this article we have mainly discussed the concepts, strategies and applications to enhance the antibacterial activity of different assemblies with some of the well-established antibacterial drugs/agents. The enhanced antibacterial activity of hydrogel, gelatin composite film, bismuth oxide nanoparticles and sanguinarine drug in the presence of cyclodextrins have been described in detail. The mechanism for the improved antibacterial activity of calixarene-capped nanoparticles, calixarene-complexed antibiotics and stimuli-responsive calixarene-based nanoassemblies for NO release was discussed. The enhanced photosensitizing effect of cucurbituril (CB) complexed porphyrins and their stimuli-responsive control over its antibacterial activity and the photothermal therapy has been elaborated. The effect of augmented antibacterial activity of CB-encapsulated drugs have also been given emphasis as they are promising for long-acting antibiotics.
... sicut mitissima satyris. Una nota testuale a Plin. Nat. 8.216
Authors: Vespa Marco 
Published: November 2023

Abstract
In book 8 of his Naturalis historia, Pliny the Elder mentions the particularly savage character of some monkeys. Most editions and translations of Pliny’s text maintain that the reference to the fierce nature of these animals concerns both the cynocephali and the satyri. However, in the manuscript Riccardianus 488 (R in the transmission of Pliny), a second hand, contemporary to the period in which the text was copied, added supra lineam the obscure term *miarsima, which would refer to the nature of the satyri in opposition to that of the cynocephali. By examining part of the ancient zoological and geographic traditions, in particular the De natura animalium by Aelian, this article defends editing the text of Pliny with the adjective mitissima, already present in the first printed editions of the Naturalis historia, as follows: Efferatior cynocephalis natura sicut mitissima satyris.
Idiome unter dem diskursiven Aspekt am Beispiel des Corona-Diskurses. Ein onomasiologischer Zugang
Authors: Woźniak Joanna 
Published: November 2023

Abstract
One of the most important issues in interpreting the role of phrasemes in discourse concerns identifying phrasemes that are typical of discourse and those that indicate discourse. This paper attempts to identify discourse-relevant idiomatic phrasemes (idioms) based on a large corpus of press texts from Süddeutsche Zeitung on the Covid-19-discourse. For this purpose, a deductive method is applied. The corpus is analysed for the keywords, -terms, and Ngrams to identify the main discourse strands. The thematic domains were determined according to the discourse strands, based on which, idioms that could potentially occur in the analysed discourse were defined onomasiologically and extracted from the phraseological dictionary. Subsequently, the extracted units were searched for in the corpus. In the final step, the relative frequency of the idioms in the studied discourse was compared with their relative frequency in reference corpora.
The chapters on the methodology and results of the study are preceded by theoretical reflections on discourse, phraseology, and attempts to combine the assumptions of these two disciplines. The study reveals that the methodology used allows for the identification of phrases that are typical of a particular discourse. First, some of the phraseological units studied actually occurred in the discourse. Second, most of the idioms with the highest frequency in the studied discourse occurred more frequently in the Covid-19-corpus than in the reference corpora. However, the method has some limitations in terms of the time required and the number of results obtained. The qualitative analysis of the idiom with the highest increase in frequency shows that it is indeed used because of the main topic of the discourse, and thus can be considered both typical and as an indicator of this discourse.
Por mí como si te operas. Constructional idioms of rejection from a constructionist approach
Authors: Ordines Pedro Ivorra 
Published: November 2023

Abstract
The present study explores partially filled idioms that go beyond the limits of the Spanish phraseological tradition, in that it focuses on semi-schematic patterns that had been relegated to the periphery and does not restrict itself to the pairing phraseological expression and lexicalized form. With a corpus comprising 592 instances extracted from the esTenTen18 corpus (Sketch Engine), the objective in the study of the constructional idioms [a PRON como si X] and [por PRON como si X] is twofold. First, to shed light on the “pragmatic point” (Kay and Fillmore 1999) of these discontinuous patterns by describing their rejection illocutionary force, their colloquial dialogic context, and their intensifying speech act; and second, to delve into the lexical variability of the constructions under study in the intersection of creativity and extravagance.