bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serendipity and Food Sensitivity: A Case Study
Authors: Gettis Alan 
Published: June 2005

SYNOPSISThe subject was a common‐migraine sufferer for many years. He kept detailed records regarding the frequency of his headaches and medication taken. An aspirin‐induced gastrointestinal bleed caused him to begin a bland oligoantigenic diet. He became headache‐free shortly thereafter. Single food challenges, done carefully and deliberately, revealed sensitivities to banana, citrus, and cheese, all foods containing potent vasoactive amines. The year prior to his serendipitous discovery, the subject had headache on 326 days and took 1316 aspirin tablets. The year following it, in which he eliminated offending foods, he had headache on 8 days and took 16 tablets. Seven years of headache data are presented. Delayed reactions to foods, and multiple food sensitivities, may pose diagnostic problems. Headaches can occur up to 72 hours following ingestion of provoking foods. Oligoantigenic diets and single food challenges utilizing enough time so as to recognize delayed reactions are useful in detecting food sensitivities.
Nimodipine versus Flunarizine in Common Migraine: A Controlled Pilot Trial
Authors: Bussone G. , Baldini S. , D'Andrea G. , Cananzi A. , Frediani F. , Caresia L. , Milone F. Ferro , Boiardi A. 
Published: June 2005

SYNOPSISThe effects of Nimodipine and Flunarizine, both calcium‐antagonist drugs, in the prevention of common migraine were investigated in a double‐blind randomized parallel study. Five patients of the 30 included in the study dropped out because of adverse reactions. Two were treated with Nimodipine and three with Flunarizine. Our results suggest a similar efficacy for both drugs, although Nimodipine seems to have a shorter latency of effect. Nimodipine is a useful new agent for common migraine prevention.
EEG Features in Basilar Artery Migraine
Authors: Jacome Daniel E. 
Published: June 2005

SYNOPSISStandard and 24‐hour ambulatory cassette electroencephalograms (EEG) were performed in 51 female patients with basilar artery migraine (BAM). None of the patients were known epileptics. The group age average was 29 years. Anomalies were detected in 9 patients (17.6%) Two exhibited paroxysmal specific (i.e., epileptogenic) and 7 paroxysmal non‐specific abnormalities. Studies during the symptomatic period on 7 patients were normal, and in one adolescent photoparoxysmal discharges were present. Her headaches persisted despite the suppression of EEG photoparoxysmal activity with valproate and carbamazepine; conversely, she was clinically improved with propranolol. EEG abnormalities occurred in the minority of adults afflicted with BAM. The presence of ictal or interictal abnormalities is not an absolute indication for antiepileptic therapy although these agents may, occasionally, be efficacious in the treatment of migraine, independent of associated EEG disturbances.
Headache Classification and Factor Analysis with a Pediatric Population
Authors: Mindell Jodi A. , Andrasik Frank 
Published: June 2005

SYNOPSISThe “Headache Symptom Questionnaire‐Revised” was administered to 68 pediatric headache sufferers and their parents. The questionnaire as a brief assessment tool can accurately classify 66.2% of the child headache sufferers. This classification accuracy was found to be equivalent to the 67.2% diagnostic agreement between experienced diagnosticians utilizing clinical interviews. Factor analysis of the questionnaire revealed four factors‐one being related to muscle contraction headaches, two factors being of a vascular nature, and the fourth factor related to both migraine and muscle contraction headache. This investigation, which utilized a population whose headaches are thought to be in a more “pure” state, continues to lend support to traditional notions of headache etiology and diagnosis.
Transformed or Evolutive Migraine
Authors: Mathew Ninan T. , Reuveni Uri , Perez Francisco 
Published: June 2005

SYNOPSIS630 (39%) of 1600 patients seen in a Headache Clinic over a three year period had chronic daily headaches (CDH). In 78% of these CDH patients, the daily headaches evolved out of a prior history of episodic migraine; these patients we designate as having “transformed” or “evolutive” migraine. The other 12% had migraine headaches which were daily from the start.Patients with transformed migraine, in contrast to those with daily headaches from the start, have a significantly higher incidence of positive family history of migraine, menstrual aggravation of migraine, identifiable trigger factors, associated G.I. and neurological symptoms, and early morning awakening with headache.The CDH group in general over‐used symptomatic medication and exhibited abnormalities on behavioral scale testing. Withdrawal of daily symptomatic medication, institution of a low tyramine low caffeine diet, initiation of prophylactic anti‐migraine therapy, and biofeedback and behavioral therapy, gave worthwhile improvement in 76% of chronic daily headache patients.Factors which promote “evolution” of migraine from intermittent to chronic daily occurrence are not well‐defined but may include medication abuse, medication withdrawal, and psychiatric disturbances.
Prior Physical and Sexual Abuse in Women with Chronic Headache: Clinical Correlates
Authors: Domino Julia V. , Haber Joel D. 
Published: June 2005

SYNOPSISPhysical and/or sexual abuse in women with chronic headache has never been addressed. This pilot study addressed differences in women with chronic headache who reported such a history, compared to a control group of women with chronic headache without a traumatic history. Thirty women were divided into two groups, based on self‐report of abuse, and all women given an MMPI as part of their assessment. Sixty‐six percent of women reported significant traumatic histories, with a mean of 8 years of abuse; headache pain developed after trauma in 100% of these cases. Abused women had shorter chronicity of headache but reported greater psycho‐social distress and significantly more headaches. Results lend support to a model of life stress etiologically involved in the development of headache. Variables related to personality prior to headache development may be more important than the chronicity determinant. Assessment and identification of abuse early in the cycle may prevent long‐term adjustment problems.
Differential Prevalence Rates for Headaches: A Function of Stress and Social Support?
Authors: Martin Paul R. , Nathan Paula R. 
Published: June 2005

SYNOPSISA recent study reported a very high headache prevalence rate for psychology undergraduate students attending a North American University. Reported here are the results of administering the same questionnaire to 711 students enrolled in the first year undergraduate psychology program at the University of Western Australia. The two studies produced dramatically different findings. The prevalence of regular headaches was 2.6 to 3.6 times as high at the North American University compared to its Australian counterpart. The average headache experienced by students attending the North American University was significantly more intense and of longer duration than the average headache experienced by students attending the Australian University. The possible causes of the differential rates were discussed, and it was suggested that the explanation lay in differences in stressors and factors that mediate the stress response. Specifically, the higher prevalence of headaches at the North American University was attributed to a greater incidence of stressors (particularly examinations), and of relatively deficient social support systems.
Tests of Thyroid Function in Chronic Headache Patients
Authors: Amy Jonathan R. 
Published: June 2005

SYNOPSISChronic, poorly localized headaches have been reported to be a not uncommon presenting complaint in patients with hypothyroidism. A study was performed to test the hypothesis that TSH measurement and TRH stimulation testing would identify some patients with hypothyroidism presenting as headache. Twenty‐one patients were tested, and none were found to be hypothyroid by these two measures. Thyroid testing may still be useful where the headache is accompanied by other symptoms of hypothyroidism, however.
Efficacy, Side Effects and Tolerance Compared During Headache Treatment With Three Different Calcium Blockers
Authors: Jónsdóttir María , Meyer John Stirling , Rogers Robert L. 
Published: June 2005

SYNOPSISExperiences gained in this laboratory during long‐term, separate prophylactic trials utilizing three different calcium channel blockers among patients with common migraine, classic migraine, mixed and chronic cluster headaches are reviewed. Nifedipine provided symptomatic improvement among 65% of patients with common migraine and among 77% of patients with classic migraine. Forty‐one percent of patients with mixed headache reported some relief of head pain. Sixty percent of patients with chronic cluster reported improved control of their headaches. Verapamil produced improved control of symptoms in 81% of patients with common migraine, 72% of those with classic, 67% of those with mixed and 79% of those with cluster. Nimodipine was reported to be beneficial among 84% of patients with common migraine, among 73% of those with classic migraine and among 53% with chronic cluster. Only 33% of patients treated with nimodipine for mixed headache reported improvement. Side effects were more common with nifedipine (71%) than with verapamil (41%) and were least common with nimodipine (20%). Tolerance developed in 42% of those treated with nifedipine and in 49% of those treated with verapamil. Development of tolerance with nimodipine was rare (4%). Each of these three calcium channel blockers showed different and specific therapeutic efficacies which differed according to the clinical classification of the different types of vascular head pain undergoing treatment.
Atenolol in Migraine Prophylaxis a Double‐blind Cross‐over Multicentre Study
Authors: Johannsson Valur , Nilsson Lars R. , Widelius Tommy , Jäverfalk Tommy , Hellman Peter , Åkesson Jan‐Åke , Olerud Bengt , Gustafsson CarI‐Lennart , Raak Anders , Sandahl Gun , Tilling Björn , Almkvist Göran , Troein Margareta 
Published: June 2005

SYNOPSISThe prophylactic anti‐migraine effect of atenolol was compared to placebo in a multicentre study on 63 patients with classical and/or common migraine. The study design was double‐blind cross‐over and patients were given atenolol 100 mg o.d. or matching placebo during a study treatment period of 24 weeks. The effect of atenolol was significantly better than that of placebo: integrated headache values were reduced in 70% of the patients (p = 0.004) and the proportion of days with headache was reduced in 59% of the patients (p = 0.010). Few side effects were reported with both atenolol and placebo. This study shows atenolol to be safe and effective in the prophylactic treatment of migraine.
Headache May Arise From Perturbation of Brain
Authors: Raskin Neil H. , Hosobuchi Yoshio , Lamb Sharon 
Published: June 2005

SYNOPSISRay and Wolff in a landmark study of human patients under local anesthesia, concluded that the brain was not sensitive to pain; however, at the time of their study, the anatomy and physiology of pain transmission and modulation were largely unknown and their stimulating electrodes were not implanted in the brainstem or thalamic cells or projections now known to be important to pain perception. We now report 15 patients, previously headache‐free, who underwent electrode implantation in the periaqueductal gray between 1977 and 1982 who immediately at implantation or in the few days subsequent to implantation reported severe continuous head pain usually with florid “migrainous” feature that persisted for 2 months to 10 years. Ten of these patients were treated with reserpine and all were dramatically responsive to it, but 8 patients rapidly became tolerant. Seven patients who were treated with dihydroergotamine rapidly became headache‐free; 2 of the 7 became tolerant quickly. One patient developed the “cough headache” syndrome after implantation, was responsive to indomethacin, the syndrome abating in 6 months. These data suggest that perturbation of brain may generate head pain.
Comparative Efficacy of Nadolol and Propranolol in the Management of Migraine
Authors: Sudilovsky A. , Elkind A.H. , Ryan R.E. , Saper J.R. , Stern M.A. , Meyer J.H. 
Published: June 2005

SYNOPSISA multicenter randomized double‐blind study was conducted on 140 patients with classic and/or common migraine who received either nadolol (80 mg or 160 mg OD) or propranolol (80 mg bid). Admission into the 12‐week active treatment period required at least 3 attacks per month during a placebo lead‐in period. Abortive headache therapy was allowed at the patients' discretion, each keeping a diary of migraine attacks and use of medications. Clinical assessments were performed monthly.Data from 42 patients were excluded from the evaluation of efficacy, mainly because of non‐adherence to protocol requirements. Drug efficacy evaluation in the remaining 98 patients was based on 4 separate migraine indices: frequency of attacks, intensity of attacks, days of pain, and need for relief medication, with success being defined as a reduction in an index of at least 50% relative to baseline. A successful response in at least I index was found in 48% of patients on nadolol 80 mg (p=NS vs propranolol 160 mg) and in 69% of the patients on nadolol 160 mg compared with 54% on propranolol 160 mg (p<0.05). Success in all 4 indices was found in 21% of patients on nadolol 80 mg (p=NS vs propranolol 160 mg) and in 41% of patients on 160 mg nadolol as compared to 15% on propranolol 160 mg (p<0.05).Adverse reactions required discontinuation from therapy in 2 of 48 patients on nadolol 80 mg (4.1%), 2 of 47 patients on nadolol 160 mg (4.3%), and 4 of 44 patients on propranolol 160 mg (9.1%).This study indicates that, in the prophylaxis of migraine, 80 mg of nadolol administered once daily is equivalent in efficacy and safety to propranolol 80 mg administered twice daily. Furthermore, nadolol given as a single daily dose of 160 mg is superior to an equal total daily dose of propranolol administered twice daily.
Aseptic Inflammatory Meningeal Reaction Manifesting as a Migrainous Syndrome
Authors: Stamboulis Eleftherios , Spengos Michael , Rombos Andonis , Haidemenos Alexandros 
Published: June 2005

SYNOPSISA female aged 24 years, without any previous personal and family history of migraine, presented with migrainous attacks characterized by headache, dizziness and nausea, accompanied by sensory, motor, visual and aphasic disturbances. The duration of the attacks ranged from 10–30 minutes, except for one episode which was accompanied by confusion and excitation and which lasted for many hours. The attacks recurred for approximately 6 weeks during which the condition of the patient was excellent between attacks. The patient recovered completely and in two years of follow‐up has not had any further migrainous attacks. The C.S.F. showed a predominantly lymphocytic pleocytosis and increased protein. A “symptomatic” migraine condition stemming from an inflammatory reaction of the meninges is thus suggested.
Treatment of Complicated Migraine with Sublingual Nifedipine
Authors: Goldner Jonathan A. , Levitt Lawrence P. 
Published: June 2005

SYNOPSISThe term complicated migraine is used when the neurologic deficits in classic migraine are intense or alarmingly prolonged. Its manifestations are felt secondary to a vasoregulatory disorder of cerebral vessels. The calcium channel antagonists have been found efficacious in blocking cerebral vasospasm. A young girl presented with severe headache, aphasia and clinical symptoms suggesting complicated migraine. Her neurologic deficit cleared immediately after the administration of sublingual nifedipine. Nifedipine may prove useful in treatment of complicated migraine.
A Case of Hemiplegic Migraine Treated with Flunarizine
Authors: Tobita Muneshige , Hino Masatoshi , Ichikawa Nobumichi , Takase Sadao , Ogawa Akira 
Published: June 2005

SYNOPSISA patient with hemiplegic migraine who was treated successfully with flunarizine is presented. A fifteen‐year‐old boy developed right hemiparesis during several migraine attacks. Regional cerebral blood flow (CBF) measurement using intravenously injected xenon 133 showed that the CBF was about 10‐15% lower in left fronto‐temporo‐parietal regions than that on the contra‐lateral side. After the treatment with flunarizine at a dose of 10 mg/day, he has been free of migraine attacks and hemiparesis disappeared. Regional CBF 1 month after treatment showed no decrease in any region of the brain. The findings indicate that flunarizine reversed the neurological deficits by increasing CBF by its vasodilating action.
Biofeedback and Relaxation Training: The Effect on Headache and Associated Symptoms
Authors: Smith Wendy B. 
Published: June 2005

SYNOPSISPatients suffering with migraine and muscle contraction headaches were treated with EMG and thermal biofeedback and relaxation training. Three groups were formed: Patients whose last contact with the practice was 3–12, 13–24, or 25 or more months prior to the follow‐up study. Each group included patients who never attended biofeedback, who attended one session, two to six sessions, or seven or more sessions of biofeedback. A telephone questionnaire revealed that 86% of patients who attended seven or more sessions of biofeedback maintained a 75–100% reduction in headache frequency through time (25 or more months). Of these patients, 65.5% reported a reduction in associated symptoms. Only 31% of patients who never attended biofeedback reported a reduction in headache frequency. Only 16.3% of patients who never attended biofeedback reported a reduction in associated symptoms. The combination of biofeedback and relaxation training clearly results in a reduction of both headache experience as well as in associated symptoms.
Nerves and Vessels in the Pterygopalatine Fossa and Symptoms of Cluster Headache
Authors: Hardebo Jan Erik , Elner Åke 
Published: June 2005

SYNOPSISThe study evaluates the contribution of activated parasympathetic and sensory nerve fibres in the sphenopalatine ganglion area, and of vasodilation in surrounding vessels in this narrow region (pterygopalatine fossa), to the pain and signs of autonomic dysfunction seen during attacks of cluster headache. Agents with anesthetic and vasoconstrictor effects were applied nasally to reach this area. It was found that the anesthetic effect is the most important, both regarding pain and autonomic symptoms. The effectiveness was also evaluated: this treatment is useful to stop attacks of cluster headache, but the beneficial effect is less than that reported in previous studies.
Menstrual Migraine: New Biochemical and Psychological Aspects
Authors: Nattaro Giovanni , Aliais Gianni , Lorenzo Cristina De , Torre Eugenio , Ancona Mario , Benedetto Chiara , Massobrio Marco 
Published: June 2005

SYNOPSISEighteen patients suffering from true menstrual migraine and 11 control subjects were studied.We evaluated in different phases of the menstrual cycle and during the migraine crisis the platelet sensitivity to prostacyclin (PSP) and the platelet content of 5‐HT. We also investigated both in basal conditions (follicular phase of the cycle) and during the migraine attack the levels of anxiety and depression. Some personality traits (psychoticism, extroversion and neuroticism) were also analyzed.The trends observed in the two groups are significantly different for both PSP (p<0.02) and 5‐HT (p<0.01).Our data suggest the hypothesis that a change in platelet homeostasis, mainly evident in the luteal and perimenstrual phases of the cycle, can play a remarkable role in menstrual migraine pathogenesis.From the psychological point of view, these patients are normal, even if they are significantly less extroverted (p< 0.005), more anxious (p<O.05) and more depressed (p<0.05) than controls.The clinical features and the cyclic unavoidable recurrence of the menstrual crisis could account for this particular psychological picture.
Prophylaxis of Migraine with Anionic Polyelectrolytes
Authors: Thonnard‐Neumann Ernst , Bigelow Llewellyn B. 
Published: June 2005

SYNOPSISIn previous studies on patients with migraine headaches we found that 50% had reduced concentrations of basophils and lymphocytes. Treatment with inhalations of heparin often restored these blood indices to normal and was accompanied by a reduction in migraine headache, We report here data on the long term treatment of 37 migraine patients with inhalations of heparin and with an oral semi‐synthetic heparinoid, Pentosan Polysulfate (PNP). 27 patients responded with a mean improvement in migraine index of 79% and as a group showed significant increases in basophil, total lymphocyte, and in particular T‐cell concentrations.Ten patients whose migraine headaches were related to their menstrual cycles were relatively unresponsive to heparin or PNP. They had a general leukopenia, but basophils were within normal range.
Common Migraine: Criteria for Diagnosis
Authors: Solomon Seymour , Cappa Karen Guglielmo , Smith Charles R. 
Published: June 2005

SYNOPSISCurrent definitions of common migraine are not specific and new criteria are needed. Our concept of common migraine was supported by comparing the features of 100 consecutive patients we diagnosed as common migraine, with past series. The features of our patients with common migraine were then compared with 100 cases of chronic daily headache, the only form of “tension headache” that can unequivocally be differentiated from migraine. The features that occurred significantly (P<0.001) more often in patients with common migraine than in those with chronic daily headache, were nausea, vomiting, unilateral site, throbbing quality, photophobia or phonophobia, increase with menstruation, and a family history of migraine. Criteria using these features, as well as other sets of criteria, were evaluated by retrospectively applying them to the patients diagnosed as having common migraine and chronic daily headache.
On the Origin of Head Pain
Authors: Raskin Neil H. 
Published: June 2005

SYNOPSISClinical, pharmacological and biochemical evidence converge upon perturbed serotonergic neurotransmission as a putative mechanism of headache. The evidence is reviewed, drawing upon the clinical examples of cerebral infarction, arteriovenous malformation, migraine and cluster headache. Ordinary, periodic headache may be the “noise” of serotonergic neurotransmission.
Pattern‐reversal Visual Evoked Potentials and EEG Correlations in Common Migraine Patients
Authors: Mariani Emilio , Moschini Vincenzo , Pastorino Giancarlo , Rizzi Franco , Severgnini Amelia , Tiengo Mario 
Published: June 2005

SYNOPSIS22 migraine patients, aged between 17 and 60 years (7 males and 15 females) were studied through the method of Visual Evoked Potentials (VEP). The control group consisted of an equal number of healthy subjects, comparable for age and sex. Correlations between the results obtained with VEP and those reported by traditional EEG methods were investigated. As found by other authors, VEP's did not point to any significant difference in common migraine as compared to a control group of healthy subject.Unlike other authors we found the presence of mildly abnormal EEG elements in only 19% of patients.
Cardiac Murmurs Indicative of Aortic Valve Disease with Chronic and Excessive Intake of Ergotamine
Authors: Spierings Egilius L. H. 
Published: June 2005

SYNOPSISTwo patients are reported who developed cardiac murmurs indicative of aortic valve disease during chronic and excessive intake of ergotamine. Ergotamine is an antimigraine medication chemically related to methysergide of which endocardial fibrosis is a rare but well‐established side‐effect.