bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surrounded by Giants: Habitable Zone Stability Within the HD 141399 System
Authors: Kane Stephen R. 
Published: October 2023

Abstract
The search for exoplanets has revealed a diversity of planetary system architectures, the vast majority of which diverge significantly from the template of the solar system. In particular, giant planets beyond the snow line are relatively rare, especially for low-mass stars, placing the solar system within a small category of systems with multiple giant planets at large separations. An exoplanetary system of note is that of HD 141399, consisting of a K-dwarf host star that harbors four giant planets with separations extending to ∼4.5 au. The architecture of the system creates a complex pattern of mean motion resonances and gravitationally perturbed regions that may exclude the presence of other planets, including within the habitable zone of the system. Here, we present the results of dynamical simulations that explore the interaction of the known planets of the system, their apsidal trajectories, resonance locations, and dynamical evolution. We further investigate the results of injecting Earth-mass planets and provide the regions of dynamical viability within the habitable zone where terrestrial planets may maintain long-term stability. We discuss these results in the context of the importance of giant planets for volatile delivery and planetary habitability considerations.
ChatGPT: ethical concerns and challenges in academics and research
Authors: Guleria Ankita , Krishan Kewal , Sharma Vishal , Kanchan Tanuj 
Published: October 2023

Introduction: The emergence of artificial intelligence (AI) has presented several opportunities to ease human work. AI applications are available for almost every domain of life. A new technology, Chat Generative Pre-Trained Transformer (ChatGPT), was introduced by OpenAI in November 2022, and has become a topic of discussion across the world. ChatGPT-3 has brought many opportunities, as well as ethical and privacy considerations. ChatGPT is a large language model (LLM) which has been trained on the events that happened until 2021. The use of AI and its assisted technologies in scientific writing is against research and publication ethics. Therefore, policies and guidelines need to be developed over the use of such tools in scientific writing. The main objective of the present study was to highlight the use of AI and AI assisted technologies such as the ChatGPT and other chatbots in the scientific writing and in the research domain resulting in bias, spread of inaccurate information and plagiarism.
Methodology: Experiments were designed to test the accuracy of ChatGPT when used in research and academic writing.
Results: The information provided by ChatGPT was inaccurate and may have far-reaching implications in the field of medical science and engineering. Critical thinking should be encouraged among researchers to raise awareness about the associated privacy and ethical risks.
Conclusions: Regulations for ethical and privacy concerns related to the use of ChatGPT in academics and research need to be developed.
Rosset, allégateur hasardeux de Montaigne
Authors: Hubert Mathieu 
Published: October 2023

À l’appui de sa pensée, Clément Rosset aime s’entourer de certains philosophes et les citer. Montaigne tient une place privilégiée parmi ceux-là, et l’usage qu’en fait Rosset est exemplaire de son ordinaire manière de procéder : il ne le convoque que lorsqu’il s’accorde avec ses propres vues philosophiques, et la parole qui lui est donnée est passée au crible légitimant de la pensée rossetienne. Mais si la pratique rossetienne de l’allégation est quelque peu orientée, elle n’en demeure pas moins singulièrement riche et suggestive, et, en contrepartie de la réduction des singularités des auteurs qu’il cite à quelque commode abstraction, elle offre d’enthousiasmantes perspectives sur l’histoire de la philosophie.
Trail-Running and Ultramarathon: A Multidisciplinary Scoping Review
Authors: Plard Mathilde , Lancelevé Simon , Martineau Aurélien 
Published: October 2023

Les recherches sur les courses à pied d’ultra-endurance se multiplient, et témoignent de la popularité de ce sport. Quelles places occupent les sciences humaines et sociales dans la compréhension de cette pratique ? Cet article contribue à préciser la compréhension d’un véritable phénomène de société à partir d’une revue de littérature pluridisciplinaire dans le domaine des sciences humaines et sociales sur l’ultra-trail. Une analyse qualitative systémique de leur contenu permet d’identifier trois thèmes majeurs : 1) Engagement et profils des coureurs d’ultra-trail ; 2) Motivations et expériences de ses participants ; 3) Territoires et événements du trail running. Ces résultats ont permis de synthétiser les travaux réalisés à ce jour et constituent un point de départ pour développer d’autres approches. Il apparaît qu’au-delà des ancrages disciplinaires, les résultats présentés résonnent entre eux autant qu’ils mettent en évidence un certain nombre de paradoxes, ce qui est représentatif de la discipline elle-même. Au vu de ces observations, certaines pistes peuvent être explorées pour approfondir ces approches et ces études.
Antioxidant capacity of value-added sandwich cookie creams based on red palm olein during storage
Authors: Mohamad Shah N.K. , Sanny M. , Ab Karim N.A. , Kuppan K. , Yahaya N.A. , Mat Yusoff M. 
Published: October 2023

Red palm olein (RPOL) is naturally rich in antioxidants, yet changes in its antioxidant capacity during storage were uncertain, which limited the application of RPOL in fat-based food products. Therefore, this study incorporated shortenings composed of 0, 5, and 10% (w/w) RPOL into sandwich cookie creams of SCC-0, SCC-5, and SCC-10, respectively, and determined their antioxidant capacity during storage for six months at 20, 30, and 35 ºC. Both SCC-5 and SCC-10 exhibited higher carotene, tocopherol, tocotrienol, and total phenolic content (TPC) than that of SCC-0, yet all SCCs were comparable in their free fatty acid (FFA) and UV-total oxidation values. After six months, the SCCs exhibited low TPC and FFA, yet were high in DPPH scavenging activity. At 20 and 30 ºC, both SCC-5 and SCC-10 oxidized more slowly than that of SCC-0. These findings proved the antioxidant capacity of RPOL, which delayed oxidation reactions in the SCCs during storage.
Antioxidant and anticancer activities of peanut (Arachis hypogaea L.) skin ultrasound extract
Authors: Hammad K.S.M. , El-Roby A.M. , Galal S.M. 
Published: October 2023

This study evaluates the effect of ultrasound-assisted extraction on the extractability of polyphenols from peanut skins (PS) and their antioxidant, and anticancer activities. The extraction was performed with solid/solvent ratios of 1:20 and 1:30 (w/v) at ultrasound intensity ranging from 5.8 to 15.4 W/cm2 for different extraction times (10, 20, 30 and 40 min). The highest polyphenol yield was 167.46 mg GAE/g dried PS. The most abundant polyphenols were catechin, syringic acid, and vanillic acid. The PS ultrasound extract (PSUE) increased the oxidative stability of sunflower oil by four times its initial level. PSUE possessed high inhibitory activity against MCF-7, HepG-2, HCT-116, and PC-3 cancer cell lines, with IC50 ranging from 1.85 ± 0.13 to 6.1 ± 0.43 μg/ml. In addition, the cytotoxicity of PSUE was examined on HFB4 human normal melanocytes using the MTT assay. These results suggest that PSUE can be used as a natural antioxidant and anticancer agent.
“Strawberry fields forever”: flower-inhabiting thrips (Thysanoptera: Thripidae) communities and their spatial interactions in strawberry agroecosystems in Québec, Canada, with first mention of pest Frankliniella intonsa (Trybom)
Authors: Canovas Morgane , Guay Jean-Frédéric , Fournier Valérie , Cloutier Conrad 
Published: October 2023

Abstract
Thrips (Thysanoptera: Thripidae) communities in agroecosystems are poorly known, particularly in Québec, Canada, where thrips can cause damage in strawberry crops. The phenology of anthophagous thrips and their use of cultivated and wildflower resources were monitored in strawberry agroecosystems, encompassing strawberry (Rosaceae) fields and adjacent uncultivated margins, on Orléans Island, Québec, Canada. A community comprised of 11 thrips species was described, dominated during the whole season by pest species Frankliniella tritici and F. intonsa, which is a first mention in Eastern Canada. Surprisingly, the major strawberry pest F. occidentalis was absent in our samples. Thrips species richness and abundance on wildflowers varied, with few flowering plant species supporting a majority of the community. Sampling sites and local wildflower presence influenced the thrips species assemblage observed on strawberry crops. Such a high thrips diversity was unexpected in this agroecosystem. The identified associations between pest thrips and wildflower species will be useful to develop better control programmes in strawberry crops.
Utility of Preoperative Brain Natriuretic Peptide and Cardiac Troponin I in Predicting Perioperative Major Adverse Cardiovascular Events in Elderly Patients Undergoing Noncardiac Surgery
Authors: Renga Sujay , Beevi Anakha Abdul Shereef Sabiathu 
Published: October 2023

Abstract

Background:
Major adverse cardiovascular events (MACEs) are frequently encountered in patients undergoing noncardiac surgeries. This study evaluated the utility of cardiac troponin I (cTnI) and brain natriuretic peptide (BNP) to predict MACE in elderly patients (aged ≥60 years) undergoing noncardiac surgeries.

Methods:
This comparative cross-sectional study was carried out at a tertiary care center in India between November 2016 and August 2018. A total of 136 consecutive patients (aged ≥60 years) presenting for noncardiac surgeries under general/spinal/regional anesthesia in the departments of surgery, orthopedics, or gynecology were included in the study. Patients with chronic kidney disease stages 4 and 5 and those receiving hemodialysis or peritoneal dialysis for renal failure were excluded from the study. Peripheral blood samples for BNP and cTnI were obtained within 24 h preoperatively. The primary endpoint was the occurrence of MACE, defined as the composite of cardiac death, nonfatal myocardial infarction, heart failure, arrhythmias, and cardiac arrest at 6 days postsurgery.

Results:
The mean age of patients was 69.41 ± 7.56 years. Females comprised 54.1% of the study population. During the perioperative period and follow-up of 6 days, 12 MACE were recorded. Preoperative cTnI levels alone or both cTnI and BNP together (cTnI levels >0.07 ng/mL and BNP levels >40 pg/mL) increased significantly in the patients who experienced MACE (P < 0.05). The area under receiver operating characteristics curve for cTnI and BNP for predicting perioperative cardiac events was 0.817 (95% confidence interval [CI] 0.646–0.988; P < 0.001) and 0.520 (95% CI 0.337–0.704; P = 0.817), respectively.

Conclusions:
In elderly patients undergoing noncardiac surgeries, a preoperative assessment of BNP and cTnI may help in the assessment of MACE.
Gray zone of hepatitis B virus infection
Authors: Lim Young-Suk 
Published: October 2023

Abstract
A substantial proportion of patients with chronic hepatitis B (CHB) do not fall into any of the defined phases and are considered to be in the “gray zone” or “indeterminate phase.” Most of the current clinical practice guidelines have no recommendations for antiviral treatment for them. However, the gray zone CHB patients with significant hepatitis B virus levels (>2000 IU/mL) and persistently normal alanine aminotransferase (ALT) levels have a significantly high risk of hepatic inflammation, fibrosis, and hepatocellular carcinoma. The molecular, clinical, and economic data that we have reviewed collectively in this article provide support for simplification of treatment initiation strategies that incorporate broader treatment of adult patients with CHB in the gray zone (hepatitis B virus [HBV] DNA ≥2000 IU/mL), regardless of ALT levels.
Knowledge, attitudes, and practices for using and disposing of antibiotics: A cross-sectional study at an Indonesian community
Authors: Zairina Elida , Azzahrya Athaya B , Nugraheni Gesnita , Sulistyarini Arie 
Published: October 2023

Background: Antibiotic misuse and improper disposal contribute to the rise in antibiotic resistance.
Objective: This study aimed to assess the knowledge, attitude, and practice of antibiotic use and disposal in Surabaya communities.
Method: An electronic questionnaire was circulated through social media using convenience sampling. The data was then analysed descriptively, and any correlation between variables was analysed using SPSS.
Result: The research showed that most of the respondents had good knowledge (71.6%), a positive attitude (68.2%), and good practice (78%). The correlation test showed a strong positive correlation between knowledge and practice (r = 0.568; p < 0.05).
Conclusion: Most respondents demonstrated good knowledge, attitude, and practice. Nonetheless, education on rational antibiotic use and proper disposal should be significantly expanded.
Assessment of pharmaceutical inventory management in an Indonesian district health office: A pioneer study during the Covid-19 pandemic
Authors: Suprapto Hadi , Nita Yunita , Hermansyah Andi 
Published: October 2023

Background: Pharmaceutical inventory management (PIM) is important for efficient budgeting and cost control of medicines. This is particularly critical for local health offices in Indonesia, especially during the Covid-19 pandemic.
Objective: To assess the PIM in the Gunungkidul health office in Indonesia.
Method: A cross-sectional descriptive study evaluating inventory data was conducted between January and May 2022. Data obtained from 2019 to 2021 were triangulated with other data from the Ministry of Health and public health centres in Gunungkidul.
Results: The availability of medicine items as compared to the national formulary was 95% (2019), 94% (2020), and 90% (2021), respectively. Purchasing budget was achieved at 96% (2019), 87% (2020), and over 120% (2021), respectively. The Inventory Turnover Ratio was between 1.23 and 1.49. The shortage of medicine occurs at a minimum rate of 15% per year. This was in contrast with overstocking at 35% for a particular medicine. Expired medicine was found at the rate of 8% (2019), 5% (2020), and 13%(2021) respectively.
Conclusion: The Covid-19 pandemic has presented significant challenges in the pharmaceutical inventory management in Gunungkidul as indicated by irregularities in the planning and procurement trajectories. The inability to anticipate crises due to the pandemic has contributed to poor management of pharmaceuticals.
Alzheimer's disease from a diabetic brain: Exploring the molecular process to determine the potential therapy target from marine sources
Authors: Rivarti Arina Windri , Saputri Legis Ocktaviana , Harahap Herpan Syafii , Permatasari Lina 
Published: October 2023

Background: The prevalence of Alzheimer’s Disease (AD) among Type 2 Diabetes Mellitus (T2D) patients has reached almost 30%. Despite the rapid development, treatments for patients with T2D have not succeeded in controlling the neurodegenerative processes that occur in these patients' brains, leading to AD pathology. Several studies have demonstrated that marine sources can inhibit several AD pathogenesis pathways in T2D patients. This review aimed to determine the effect of marine species-sourced compounds at the molecular level in inhibiting and preventing the pathogenesis of AD in T2D patients.
Method: Combinations of several terms were used to search for peer-reviewed literature published in PubMed, Scopus, and Google Scholar.
Result: Marine organisms-sourced compounds inhibited various target signalling pathways between T2D and AD, such as an inhibitor of β-site-amyloid precursor protein cleaving enzyme 1 (BACE1) also known as β-secretase, glycogen synthase kinase-3 beta (GSK3B), insulin degradation enzyme (IDE), the mammalian target of rapamycin (mTOR), nuclear factor kappa-light-chain-enhancer (NF-κb), and nuclear factor erythroid 2-related factor 2 (Nrf2).
Conclusion: Marine sources can be considered as a potential therapy to prevent or slow AD progression in T2D patients.
The profile of cold chain management of vaccines in primary healthcare centre in Kupang, Indonesia
Authors: Rahmat Emanuel Gerald Alan , Yunita Nita  , Yuni Priyandani  
Published: October 2023

Background: Vaccine quality is strongly influenced by the cold chain application in vaccine storage and distribution at the Primary Healthcare Center.
Objective: This study aimed to describe the cold chain management in storing and distributing vaccines at the Primary Healthcare Centre in the Kupang City area.
Method: This study was a cross-sectional study. The data collection instrument used a checklist sheet containing 27 vaccine storage parameters and 8 (eight) vaccine distribution parameters. The research look at the vaccine storage and distribution. The sample uses the entire population, namely 11 Primary Healthcare Centre in the City of Kupang.
Result: It was found that 19 vaccine storage criteria had been implemented in all Primary Healthcare Centre. Eight storage criteria had not been implemented in all Primary Healthcare Centre. Furthermore, in the distribution practice category of eight criteria, five of them had been implemented by all Primary Healthcare Center, while three criteria had not been met. Practice that need to be improved were in thermometer calibration, availability of storage and distribution SOPs, validation of delivery equipment, availability of storage room air circulation equipment.
Conclusion: To conclude, the implementation of cold chain in vaccine storage and distribution practices in 11 sub-district healthcare centers was not optimal, therefore it needs to be improved.
Activities of sondhep herbs to cause changes in IL-1β in an osteoarthritis rat model
Authors: Widyowati Retno , Rosyidah Iffatur , A’yun Via Qurrota , Oktarina Rice Disi , Sholikhah Irawati , Sahu Ram Kumar 
Published: October 2023

Background: Osteoarthritis (OA) is a slowly progressive and degenerative joint disease. Symptoms of pain and inflammation are influenced by IL-1β, which increases COX-2 enzyme activity and PGE2 production. Sumenep Sondhep herbs are used by the community for joint pain.
Objective: To evaluate the activities of the Sumenep Sondhep herb in reducing the cytokine IL-1β in the OA rats model.
Methods: Monosodium iodoacetate (MIA) induction was carried out on animal OA models. Rats were treated with Sondhep extract for 28 days. Knee diameter and hyperalgesia responses were recorded every week until the 7th week. The IL-1β levels were observed on the 21st and 49th days using the ELISA method.
Results: There was a significant difference in decreasing the diameter of the rat's knee (p < 0.05), increasing the hyperalgesia test in the rats (p < 0.05), and decreasing IL-1β levels between before and after treatment (p < 0.05).
Conclusion: The Sondhep Sumenep herb has activity against osteoarthritis by reducing pro-inflammatory cytokine IL-1β in OA rat models.
Knowledge and perception of pharmacovigilance among pharmacy students and pharmacy professional students
Authors: Kurniawati Fivy , Hakim Arief Rahman , Novitasari Pradipta Dwinisa , Kumalasari Pratiwi Dian , Hamidah Lulu Wana 
Published: October 2023

Background: Adverse Drug Reaction (ADR) contributes to high morbidity and mortality rate worldwide. This can be minimised through pharmacovigilance. It is important to evaluate the level of knowledge and perception of pharmacovigilance among pharmacy students.
Objective: To describe the level of knowledge and perceptions of final-year pharmacy students and students of pharmacy professional programs in Yogyakarta regarding pharmacovigilance.
Method: A cross-sectional study involved 437 pharmacy students from five different universities in Yogyakarta, who were selected using a convenience sampling technique. Data were analysed to describe the characteristics of the respondents and their level of knowledge and perceptions about pharmacovigilance.
Result: The majority of final year students in pharmacy and pharmacy professional programs had acquired a high level of knowledge about pharmacovigilance with a percentage of 54.0%. They also shared a positive perception of the implementation of pharmacovigilance with a percentage of 55.6%.
Conclusion: Final-year pharmacy students and students of the pharmacy professional program have good knowledge and perceptions towards pharmacovigilance.
In silico approach of bioactive molecule chitosan 501.1 kDa from snail shell as antioxidant and inhibitor of the keap1-nrf2 protein-protein interaction
Authors: Umarudin Umarudin , Widyarti Sri , Warsito Warsito , Rahayu Sri 
Published: October 2023

Background: ROS are created when high levels of oxidative stress occur due to hypercholesterolemia. Nuclear Factor Erythroid 2-related factor (NRF2) controls the expression of antioxidant genes. Kelch-like ECH-associated protein 1 (KEAP1) therapy degrades NRF2. Chitosan 501.1 kDa from snail shells contains bioactive chemicals that can induce NRF2 activity.
Objective: To evaluate the potential antioxidant activity of the bioactive compound in Mw 501.1 kDa chitosan by targeting KEAP1 and NRF2 proteins in-silico.
Method: The 3D structures of the bioactive compounds chitosan and control 51M were derived from the PubChem database, and the proteins were derived from the RCSB PDB. The biological activity of chitosan bioactive compounds was predicted using the PASS Online server. Molecular docking was performed using Hex 8.0.0 Cuda with Shape+Electro+DARS and visualised with Discovery Studio. The biological activity of chitosan compounds was predicted as lipotropic and antioxidant.
Result: The discovery of the bioactive compound chitosan 501.1 kDa interacted strongly with KEAP1. The bioactive compound chitosan also inhibited KEAP1 through residues GLN75 and LEU84 at the 51M-KEAP1 interaction.
Conclusion: The bioactive compound chitosan 501.1 kDa could inhibit the interaction of KEAP1-NRF2 proteins so that NRF2 could transcribe antioxidant genes. Therefore, may serve as a suitable alternative.
The Effectiveness of Anterior Cruciate Ligament Reconstruction on the Patellofemoral Stability and Patellar Height
Authors: DOĞAN Özgür , GENCER Batuhan , SÜER DOĞAN İhsaniye 
Published: October 2023

Background: Considering the critical role the anterior cruciate ligament (ACL) plays in knee biomechanics, it is a logical hypothesis that ACL reconstruction (ACLR) will have positive effects on knee kinematics, and stability. Our objective was to investigate the effect of single-bundle ACLR on patellar height, and patellofemoral balance radiologically and clinically.
Methods: In this prospective study, 87 patients operated with hamstring autograft-used single-bundle ACLR were analyzed. History of dislocation, stability-related physical examination findings, Tegner-Lysholm Knee Scoring Scale, and Kujala Anterior Knee Pain Scale were used for functional assessment. All patients underwent pre-and post-operative magnetic resonance imaging and Insall-Salvati (IS) Index, Caton Deschamps Index, Blackburne-Peel Index, and Patella-patellar tendon (P-PT) angles were measured on T1-weighted sagittal section images.
Results: A total of 79 patients (90.8%) achieved excellent or good result, according to Tegner-Lysholm Knee Scoring Scale, and the patients' postoperative 1st year mean Kujala Anterior Knee Pain Score was calculated as 90.4 (Range: 79.1 – 96.4). On physical examination, increased passive patellar translation was observed in 2 patients (2.3%), but the J sign was appeared to be negative in all the patients. While all patellar height indices decreased after reconstruction, only the decrease in IS index was statistically significant (p=0.007). Moreover, the P-PT angle was found to be significantly lower after ACLR (p