bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Consensus-Based List of Potential Quality Indicators for Fever and Inflammation of Unknown Origin
Authors: Wright William F , Betrains Albrecht , Stelmash Lauren , Mulders-Manders Catharina M , Rovers Chantal P , Vanderschueren Steven , Auwaerter Paul G 
Published: January 2024

Abstract
With a growing emphasis on value-based reimbursement, developing quality indicators for infectious diseases has gained attention. Quality indicators for fever of unknown origin and inflammation of unknown origin are lacking. An assembled group of international experts developed 12 quality measures for these conditions, which could be validated with additional study.
Creation and Validation of an Automated Registry for Outpatient Parenteral Antibiotics
Authors: Canterino Joseph , Malinis Maricar , Liu Jing , Kashyap Nitu , Brandt Cynthia , Justice Amy 
Published: January 2024

Abstract
Existing outpatient parenteral antibiotic therapy (OPAT) registries are resource intensive, and OPAT programs struggle to produce objective data to show the value of their work. We describe the building and validation of an automated OPAT registry within our electronic medical record and provide objective data on the value of the program. Variables and outcomes include age, sex, race, ethnicity, primary insurance payor, antibiotic names, infection syndromes treated, discharge disposition, 30-day all-cause readmission and death rates, complications, and an estimate of the hospital days saved. Records for 146 OPAT episodes were reviewed manually to validate the registry. Data were displayed in a dashboard within the electronic medical record. Over the 4-year time frame, our registry collected 3956 unique patients who completed 4710 episodes (approximately 1200 episodes per year). A total of 400 complications during OPAT were identified. All variables had an accuracy of &gt;90% on validation. The OPAT program resulted in a reduction in hospital length of stay by 88 820 days, or roughly 22 000 days per year. We intend our registry to serve as a blueprint for similar OPAT programs with limited administrative resources. Wider application of our system would allow for easier aggregation and comparisons of OPAT practice and address the lack interinstitutional standardization of OPAT data and outcomes.
Gravitational Wave Search through Electromagnetic Telescopes
Authors: Ito Asuka , Kohri Kazunori , Nakayama Kazunori 
Published: January 2024

Abstract
We study the graviton–photon conversion in the magnetic fields of the Earth, the Milky Way, and intergalactic regions. Requiring that the photon flux converted from gravitons does not exceed the observed photon flux with telescopes, we derive upper limits on the stochastic gravitational waves in frequency ranges from 107–1035 Hz. Remarkably, the upper limits on h2ΩGW could be less than unity in the frequency range of 1018–1023 Hz in a specific case. The detection of gravitational waves using telescopes could open up a new avenue for high frequency gravitational wave observations.
Advantages of the Kirkwood–Dirac distribution among general quasi-probabilities on finite-state quantum systems
Authors: Umekawa Shun , Lee Jaeha , Hatano Naomichi 
Published: January 2024

Abstract
We investigate the properties of quasi-joint-probability (QJP) distributions on finite-state quantum systems, especially two- and three-state systems, based on the general framework of quantum/quasi-classical representations. We show that the Kirkwood–Dirac distribution is a prime candidate among the QJP distributions that behave well in view of the following two perspectives: the information contained in the QJP distribution and its affinity to genuine joint-probability distributions. Regarding the first criterion, we show that the Kirkwood–Dirac distributions on two- and three-state quantum systems yield faithful quasi-classical representations of quantum states with a minimal set of observables, namely a pair of two different directions of spin, and thereby point out that in general the imaginary parts of the QJP distributions play essential roles in this respect. As for the second criterion, we prove that the Kirkwood–Dirac distributions on finite-state quantum systems are supported on the product set of the spectra of the quantum observables involved.
Beefing up communication skills of upper-level animal science students
Authors: Norris-Parish Shannon L , Leggette Holli R , Pesl Murphrey Theresa , Parrella Jean A , Richburg Audra , Herring Andy D 
Published: January 2024

AbstractAnimal scientists face an increasing need to communicate with the lay public because of the public’s interest in the origin and production of animal-sourced foods. Consumers’ increased interest infers a critical need for effective communication skills among animal science graduates. Effective communication skills are mandatory if students are to explain scientific information and mitigate misinformation about livestock production. The purpose of our study was to investigate the communication styles and communication effectiveness of upper-level animal science students enrolled in a beef cattle production and management course at Texas A&M University across five semesters (N = 241; spring 2018 = 61, summer 2018 = 15, Fall 2018 = 54, spring 2019 = 55, and fall 2019 = 56). Male animal science students (n = 25; 32.9%) preferred assertive and direct communication (a driver communication style) and female students (n = 32; 19.4%) preferred collaborative and accommodating communication (an amiable communication style). Students were moderately experienced with beef cattle production (M = 3.09, SD = 1.07) before enrolling in the course; however, former beef cattle experiences did not influence their preferred communication style [F(10, 230) = 0.36, P = 0.96]. Researchers also observed students’ communication skills during an end-of-semester beef cattle production and management project presentation and identified strengths and weaknesses. Students demonstrated strong, in-depth animal industry knowledge, an ability to connect beef production techniques to management success, and critical thinking skills when answering questions. Oral communication skills warranting improvement included integrating visual aids and/or visual slides to support findings, using improved stage presence and confidence, and sharing responsibilities when presenting as a team. Finally, completion of a supplemental communication training module, intended to develop oral communication skills, significantly improved [F(1, 55) = 4.16, P = 0.046] students’ beef cattle production and management project presentation scores. As students become aware of their communication preferences and tendencies, they become equipped to adjust their communication practices and techniques when needed. Through this study, we gained insight into students’ communication tendencies and skills, which can be used to provide curricular recommendations and enhance students’ workforce readiness.
Sodium and Its Impact on Outcome After Aneurysmal Subarachnoid Hemorrhage in Patients With and Without Delayed Cerebral Ischemia
Authors: Labib Homeyra , Tjerkstra Maud A. , Coert Bert A. , Post René , Vandertop W. Peter , Verbaan Dagmar , Müller Marcella C.A. 
Published: January 2024

OBJECTIVES:
To perform a detailed examination of sodium levels, hyponatremia and sodium fluctuations, and their association with delayed cerebral ischemia (DCI) and poor outcome after aneurysmal subarachnoid hemorrhage (aSAH).

DESIGN:
An observational cohort study from a prospective SAH Registry.

SETTING:
Tertiary referral center focused on SAH treatment in the Amsterdam metropolitan area.

PATIENTS:
A total of 964 adult patients with confirmed aSAH were included between 2011 and 2021.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
A total of 277 (29%) developed DCI. Hyponatremia occurred significantly more often in DCI patients compared with no-DCI patients (77% vs. 48%). Sodium levels, hyponatremia, hypernatremia, and sodium fluctuations did not predict DCI. However, higher sodium levels were significantly associated with poor outcome in DCI patients (DCI onset –7, DCI +0, +1, +2, +4, +5, +8, +9 d), and in no-DCI patients (postbleed day 6–10 and 12–14). Also, hypernatremia and greater sodium fluctuations were significantly associated with poor outcome in both DCI and no-DCI patients.

CONCLUSIONS:
Sodium levels, hyponatremia, and sodium fluctuations were not associated with the occurrence of DCI. However, higher sodium levels, hypernatremia, and greater sodium fluctuations were associated with poor outcome after aSAH irrespective of the presence of DCI. Therefore, sodium levels, even with mild changes in levels, warrant close attention.
Pivoting Continuing Professional Development During the COVID-19 Pandemic: A Narrative Scoping Review of Adaptations and Innovations
Authors: Soklaridis Sophie , Chowdhury Mushfika , Turco Mary G. , Tremblay Martin , Mazmanian Paul , Williams Betsy , Besa Reena , Sockalingam Sanjeev 
Published: January 2024

Introduction:
Most formal continuing professional development (CPD) opportunities were offered in person until March 2020 when the COVID-19 pandemic disrupted traditional structures of CPD offerings. The authors explored the adaptations and innovations in CPD that were strengthened or newly created during the first 16 months of the pandemic.

Methods:
The objectives of the narrative review were to answer the following questions: (1) what types of adaptations to CPD innovations are described? and (2) what may shape future innovations in CPD? The following databases were searched: Medline, Embase, CINAHL, and ERIC to identify the literature published between March 2020 to July 2021. The authors conducted a comprehensive search by including all study types that described adaptations and/or innovations in CPD during the stated pandemic period.

Results:
Of the 8295 citations retrieved from databases, 191 satisfied the inclusion criteria. The authors found three categories to describe adaptations to CPD innovations: (1) creation of new online resources, (2) increased use of the existing online platforms/software to deliver CPD, and (3) use of simulation for teaching and learning. Reported advantages and disadvantages associated with these adaptations included logistical, interactional, and capacity building elements. The review identified five potential future CPD innovations: (1) empirical research on the effectiveness of virtual learning; (2) novel roles and ways of thinking; (3) learning from other disciplines beyond medicine; (4) formation of a global perspective; and (5) emerging wellness initiatives.

Discussion:
This review provided an overview of the adaptations and innovations that may shape the future of CPD beyond the pandemic.
Current role of radiomics and radiogenomics in predicting oncological outcomes in bladder cancer
Authors: O’Sullivan Niall J. , Temperley Hugo C. , Corr Alison , Meaney James F.M. , Lonergan Peter E. , Kelly Michael E. 
Published: January 2024

Abstract

Background
Radiomics refers to the conversion of medical images into high-throughput, quantifiable data to analyze disease patterns, aid decision-making, and predict prognosis. Radiogenomics is an extension of radiomics and involves a combination of conventional radiomics techniques with molecular analysis in the form of genomic and transcriptomic data. In the field of bladder cancer, studies have investigated the development, implementation, and efficacy of radiomic and radiogenomic nomograms in predicting tumor grade, gene expression, and oncological outcomes, with variable results. We aimed to perform a systematic review of the current literature to investigate the development of a radiomics-based nomogram to predict oncological outcomes in bladder cancer.

Materials and methods
The Medline, EMBASE, and Web of Science databases were searched up to February 17, 2023. Gray literature was also searched to further identify other suitable publications. Quality assessment of the included studies was performed using the Quality Assessment of Diagnostic Accuracy Studies 2 and Radiomics Quality Score.

Results
Radiogenomic nomograms generally had good performance in predicting the primary outcome across the included studies. The median area under the curve, sensitivity, and specificity across the included studies were 0.83 (0.63–0.973), 0.813, and 0.815, respectively, in the training set and 0.75 (0.702–0.838), 0.723, and 0.652, respectively, in the validation set.

Conclusions
Several studies have demonstrated the predictive potential of radiomic and radiogenomic models in advanced pelvic oncology. Further large-scale studies in a prospective setting are required to further validate results and allow generalized use in modern medicine.
Sodium Hydrosulfide Reverts Chronic Stress–Induced Cardiovascular Alterations by Reducing Oxidative Stress
Authors: Beltran-Ornelas Jesus H. , Silva-Velasco Diana L. , Tapia-Martínez Jorge A. , Sánchez-López Araceli , Cano-Europa Edgar , Huerta de la Cruz Saúl , Centurión David 
Published: January 2024

Abstract:
Chronic stress induces a group of unrecognized cardiovascular impairments, including elevated hemodynamic variables and vascular dysfunction. Moreover, hydrogen sulfide (H2S), a gasotransmitter that regulates the cardiovascular system decreases under chronic stress. Thus, this study assessed the impact of sodium hydrosulfide (NaHS) (H2S donor) on chronic restraint stress (CRS)–induced cardiovascular changes. For that purpose, male Wistar rats were restrained for 2 hours a day in a transparent acrylic tube over 8 weeks. Then, body weight, relative adrenal gland weight, serum corticosterone, H2S-synthesizing enzymes, endothelial nitric oxide synthetize expression, reactive oxygen species levels, lipid peroxidation, and reduced glutathione-to-oxidized glutathione (GSH2:GSSG) ratio were determined in the thoracic aorta. The hemodynamic variables were measured in vivo by the plethysmograph method. The vascular function was evaluated in vitro as vasorelaxant responses induced by carbachol or sodium nitroprusside, and norepinephrine (NE)-mediated vasocontractile responses in the thoracic aorta. CRS increased (1) relative adrenal gland weight; (2) hemodynamic variables; (3) vasoconstrictor responses induced by NE, (4) reactive oxygen species levels, and (5) lipid peroxidation in the thoracic aorta. In addition, CRS decreased (1) body weight; (2) vasorelaxant responses induced by carbachol; (3) GSH content, and (4) GSH2:GSSG ratio. Notably, NaHS administration (5.6 mg/kg) restored hemodynamic variables and lipid peroxidation and attenuated the vasoconstrictor responses induced by NE in the thoracic aorta. In addition, NaHS treatment increased relative adrenal gland weight and the GSH2:GSSG ratio. Taken together, our results demonstrate that NaHS alleviates CRS-induced hypertension by reducing oxidative stress and restoring vascular function in the thoracic aorta.
Analgesic effects of ibuprofen soft and flexible absorbent foam dressing after colorectal surgery: A single-center comparative study
Authors: Cheng Tzu-Yen , Kiu Kee-Thai , Yen Min-Hsuan , Tam Ka-Wai , Chang Tung-Cheng 
Published: January 2024

Abstract

Background
Postoperative wound care and pain management are crucial components of the postoperative recovery process. This study aims to evaluate whether the analgesic effects of the ibuprofen soft and flexible absorbent foam dressing are superior to those of traditional gauze after colorectal surgery.

Materials and Methods
Data pertaining to patients who underwent colorectal surgery between May 2021 and January 2022 were extracted from the electronic medical records database archive of a single institution. The ibuprofen soft and flexible absorbent foam dressing was applied to 62 patients for postoperative wound care, whereas gauze was used for 78 patients. Primary outcome measurements included the count of dressings, visual analog scale pain scores, analgesic dosage, complications, and length of hospitalization.

Results
The mean pain score on the 5th day postoperation was significantly lower for the ibuprofen group (2.03 ± 1.55) than for the control group (2.63 ± 1.72, p = 0.035). The mean dosage (mg) of parecoxib on the 3rd day postoperation was significantly lower for the ibuprofen group (2.58 ± 12.27) than for the control group (10.26 ± 21.80, p = 0.01). The cumulative number of dressing changes during the 1st week postoperation was significantly lower for the ibuprofen group (mean ± standard deviation, 3.00 ± 0.98) than for the control group (7.55 ± 2.68, p < 0.001). No significant differences were observed in the complication rate or length of hospitalization between the groups.

Conclusions
The ibuprofen soft and flexible absorbent foam dressing can either enhance the analgesic effect during postoperative recovery or reduce the cost and dressing time associated with postoperative wound care.
Immunologic landscape of human hepatic hemangiomas and epithelioid hemangioendotheliomas
Authors: Thomann Stefan , Metzler Thomas , Tóth Marcell , Schirmacher Peter , Mogler Carolin 
Published: January 2024

Background:
The missing requirement for resection for the majority of hepatic hemangiomas (HH) and tissue scarcity for rare diseases such as hepatic epithelioid hemangioendotheliomas (HEHE) complicate the characterization of the spatial immunovascular niche of these benign and malignant vascular neoplastic diseases.

Methods:
Two tissue cohorts containing 98 HHs and 13 HEHEs were used to study entity-specific and disease stage–specific endothelial cell (EC) phenotype and immune cell abundance. Using semiquantitative assessment, annotation-based cell classifiers, digital cell detection on whole slides, and tissue microarrays, we quantified 23 immunologic and vascular niche-associated markers and correlated this with clinicopathologic data.

Results:
Both HH and HEHE ECs were characterized by a CD31high, CD34high, FVIII-related antigenhigh expression phenotype with entity-specific expression differences of sinusoidal EC markers Stabilin1, Stabilin2, CD32, and Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1). Cell detection identified an HH margin-prevailing immunologic response dominated by Myeloperoxidase+
(MPO+) macrophages, CD3+ and CD8+ T cell subsets, and B cells (CD20+, CD79A+). In HEHE, increased CD68+ and CD20+ cell demarcation of lesion margins was observed, while CD3+ and CD8+ T cells were equally detectable both marginally and intralesionally. Stage-specific pairwise correlation analysis of HH and HEHE revealed disease entity–specific immunologic infiltration patterns as seen by high CD117+ cell numbers in HH, while HEHE samples showed increased CD3+ T cell infiltration.

Conclusions:
ECs in HH and HEHE share a continuous EC expression phenotype, while the expression of sinusoidal EC markers is more highly retained in HEHE. These phenotypic differences are associated with a unique and disease-specific immunovascular landscape.
Feasibility of Treatment Agents in Radioactive Iodine Separation from Waste Liquids
Authors: Hirota Masahiro , Higaki Shogo , Ishida Yoshiyuki , Nakata Daisuke , Terao Keiji , Ito Shigeki 
Published: January 2024

Abstract
To discharge waste liquid containing radioactive iodine into sewage systems, long-term storage or dilution with a large amount of water may be required until the radioactivity concentration reduces below the standard value. Processing the waste liquid could be easier if radioactive iodine could be separated from the water. This study verified the effectiveness of superabsorbent polymer and α-cyclodextrin as treatment agents to separate radioactive iodine from waste liquids. Sodium iodide (Na125I) was added to purified water and artificial urine to prepare simulated waste liquids containing iodine equivalent to the urine of patients treated with radioactive iodine. The as-prepared simulated waste liquid was poured into a container with superabsorbent polymer and left for 90 d. The residual iodine rate in the simulated waste liquid was estimated by measuring 125I radioactivity. When the water was sufficiently dried, residual iodine rates on day 15 were 0.102 and 0.884 in the simulated waste liquids comprising purified water and artificial urine, respectively. The simulated waste liquid comprising purified water with 5% α-cyclodextrin absorbed by 1 g of superabsorbent polymer had a residual rate of 0.980. Moreover, the residual rate of simulated waste liquid comprising artificial urine with 2% α-cyclodextrin absorbed by 1 g of SAP was 0.949. Superabsorbent polymer combined with α-cyclodextrin was an effective treatment agent for separating radioactive iodine from waste liquids.
Significant Experiences Caring for Vascular Anomalies: A Survey of Caregivers and Adult Patients
Authors: Kerr Anna M. , Bereitschaft Christine , Goldberg Jessica , Sisk Bryan 
Published: January 2024

Objectives:
The goal of the current study was to gain a deeper understanding of the significant experiences that characterize care for vascular anomalies (VAs).

Materials and methods:
A total of 166 adult patients and 88 caregivers (N = 254) completed an anonymous online cross-sectional survey about their experiences seeking care for their (or their child’s) vascular anomaly. We used thematic analysis to analyze participants’ responses to 3 open-ended questions asking about the biggest challenges, most memorable positive experiences, and any other significant experiences.

Results:
Participants reported significant healthcare experiences representing 5 primary areas: diagnosis and treatment, healthcare system and logistics, psychosocial consequences, physical consequences, and clinical relationships. The availability of clinical knowledge and information was identified as an overarching theme affecting all 5 categories. The most common negative experiences related to healthcare system and logistics (n = 100). Clinical relationships were commonly identified in both positive (n = 100) and negative (n = 86) experiences.

Conclusion:
Their responses highlighted the value of a well-organized system of care that promotes productive interactions with expert clinicians and connects patients with support organizations. Unfortunately, VA patients and caregivers often experience long diagnostic journeys, fragmented care, and nonproductive interactions with clinicians due to the pervasive lack of information about VAs. The results indicate the need for systemic changes to address these barriers to care for patients with rare diseases.
Medical aid in dying: The role of the nurse practitioner
Authors: Harrawood Kathryn A. 
Published: January 2024

ABSTRACT
Medical aid in dying (MAID) is a practice that has been expanding in the United States over the past few decades. As it becomes a viable option for a growing portion of the American population, nurse practitioners (NPs) need to be prepared to engage in conversation with patients about the practice. Although historically only physicians were able to participate in MAID, the role has recently expanded to include additional advanced practice providers, including NPs. Reviewing the history of MAID and examining how current legislation affects clinical practice can support the NP's ability to educate and counsel patients about the option. Identifying specific areas in which MAID providers report needing additional training and support can help providers work toward delivering the highest quality patient care possible. As MAID becomes accessible to greater numbers of people, NPs need to be prepared to talk to patients who are navigating serious, life-limiting illnesses about the possibility of MAID.