bluuebunny/crossref_metadata_2025_split huggingface dataset:
Product Development: Yellow Pumpkin Donuts And RPO (Red Palm Oil) For School-Age Children
Authors: Aini Qurratu , Kusumawati Dewi , Nurjanah Hanna 
Published: November 2023

Background: Nutritional problems are crucial things to be concerned about, especially for children. Children are still growing, so their nutritional intake needs to be considered. Vitamin A deficiency still often occurs in children, even though vitamin A has a significant role in the child's growth process. Food sources that contain good sources of pro-vitamin A but are never used properly are pumpkin and Red Palm Oil (RPO). This study aims to make a product in the form of donuts, the type of snack that is of interest to children, and increase the added value of pumpkin and RPO. Methods: The research method used is Pure Experimental, which consists of several activities, starting with product trial, product manufacture, hedonic test, and product quality test. Data analysis was performed using Ms. Excel 2016.Result: The results of the overall hedonic test of the product are 4.1, which means that the product is favored by the panelists. while results of the hedonic quality test show that the product has a golden yellow color, a pleasant aroma, a sweet taste, a slightly soft texture, and a weak after taste.
Pengembangan Modul Prosedur Perhitungan Kekuatan Struktur Beton Bangunan Gedung Sederhana Menurut SNI 2847:2019
Authors: Rahman Sania Bilqisty Aulia 
Published: November 2023

Media pembelajaran efektif berperan penting dalam meningkatkan kualitas pembelajaran terutama saat online, adaptasi terhadap standar dan kurikulum relevan adalah kunci untuk hasil pembelajaran yang berkualitas. Berkaitan dengan hal ini, penelitian ini bertujuan untuk mengembangkan serta menguji kelayakan suatu media pembelajaran yang berbentuk modul, khususnya dalam penghitungan kekuatan struktur bangunan sederhana sesuai dengan standar SNI 2847:2019. Dengan menggunakan media ini, tujuan utamanya adalah memungkinkan siswa untuk belajar secara mandiri dan mencapai tujuan pembelajaran yang telah ditetapkan. Penelitian ini menggunakan pendekatan Research and Development (RD) dengan mengikuti langkah-langkah pengembangan 4D, yang mencakup tahapan Define, Design, Develop, dan Disseminate. Data yang diperlukan dalam penelitian ini dikumpulkan yaitu observasi untuk menilai kebutuhan media pembelajaran, dan penggunaan instrumen berupa angket validasi untuk menilai kelayakan modul yang dikembangkan. Validasi dilakukan oleh tiga kelompok ahli, yaitu ahli materi, ahli media, dan guru mata pelajaran Perencanaan Usaha Konstruksi dan Properti. Instrumen validasi terdiri dari dua jenis angket, yang menilai aspek materi dan aspek media. Penggunaan skala Likert digunakan dalam pengukuran angket, yang membantu mengidentifikasi masalah, menentukan konsep, dan indikator pembelajaran yang disajikan dalam media tersebut. Analisis data dilakukan secara deskriptif kualitatif. Hasil dari penelitian ini berupa sebuah modul yang membahas prosedur perhitungan kekuatan struktur bangunan sederhana sesuai dengan SNI 2847:2019, terutama fokus pada perhitungan beban, kekuatan struktur pelat, dan balok menggunakan bahan beton bertulang. Hasil validasi oleh para pakar dan guru menunjukkan bahwa media ini dinilai "sangat layak," dengan skor validasi materi mencapai 264 (persentase kelayakan sekitar 88%) dan validasi media mencapai 409 (persentase kelayakan sekitar 87%).
Pengembangan Media Pembelajaran Video Animasi Berbasis Powtoon Pada Mata Pelajaran Teknik Pengukuran Tanah di SMK
Authors: Nugraha Muhammad Faiq Sani , Sudjani Sudjani , Purwanto Dedi 
Published: November 2023

Media pembelajaran dan metode pembelajaran adalah elemen-elemen yang dapat disempurnakan oleh guru guna mencapai efektivitas dan efisiensi dalam proses pembelajaran. Dalam konteks pandemi COVID-19, siswa membutuhkan media pembelaran yang sesuai agar tujuan belajar dapat tercapai dengan baik karena masa pandemi cukup menimbulkan dampak yang signifikan pada perkembangan pembelajaran siswa. Media pembelajaran berupa video animasi merupakan alternatif yang sangat sesuai, karena memungkinkan siswa untuk belajar secara mandiri di rumah tanpa memerlukan interaksi langsung dengan guru. Tujuan dari penelitian ini adalah untuk menghasilkan sebuah perangkat lunak (software), produk yang dikembangkan merupakan media pembelajaran berupa video animasi yang menggunakan platform powtoon. Metode yang digunakan dalam penelitian ini adalah Research and Development. Penelitian ini melibatkan enam langkah penelitian yang diawali dengan pengumpulan potensi dan identifikasi masalah, pengumpulan data, perencanaan produk video, proses validasi produk yang melibatkan dua ahli media, satu ahli materi, dan satu ahli bahasa, kemudian dilanjutkan dengan tahap revisi produk, serta diakhiri dengan tahap uji coba produk yang terbatas pada 61 siswa kelas X KGSP di SMK Negeri 5 Bandung. Dari tahap validasi diperoleh hasil bahwa media ini layak digunakan tanpa revisi setelah dilakukan 2 kali uji validasi kepada ahli media dan ahli materi, serta 1 kali uji validasi kepada ahli bahasa dan diperoleh hasil persentase respon siswa sebesar 77,79% dengan kriteria positif sehingga dapat disimpulkan bahwa media pembelajaran video animasi berbasis produk powtoon mampu membantu siswa dalam melaksanakan proses pembelajaran pada mata pelajaran teknik pengukuran tanah.
Pengaruh Emotional Intelligence Terhadap Kesiapan Kerja Mahasiswa Pendidikan Teknik Bangunan Universitas Pendidikan Indonesia
Authors: Nurjaman Jajang , Suryadi Dedy , Rahayu Sri 
Published: November 2023

Society 5.0 merupakan tantangan bagi masyarakat Indonesia. Tantangan-tantangan ini menjadi penyebab semakin ketatnya persaingan untuk memasuki dunia kerja yang mengakibatkan meningkatnya jumlah pengangguran di Indonesia. Tingginya tingkat pengangguran ini, selain disebabkan oleh rendahnya kompetensi pengetahuan yang dimiliki, juga disebabkan oleh kurangnya kesiapan untuk bekerja bagi para mahasiswa. Kesiapan untuk bekerja adalah kondisi di mana individu secara mental dan fisik siap untuk melakukan aktivitas yang berkaitan dengan pekerjaan. Salah satu faktor yang memengaruhi kesiapan untuk bekerja adalah kecerdasan emosional. Seseorang dengan kecerdasan emosional yang tinggi memiliki kemampuan untuk mengendalikan diri, memiliki ketahanan dalam menghadapi rintangan, tidak puas diri berlebihan, dapat mengatur suasana hati, berempati, dan mampu mengendalikan emosinya sehingga ia mampu mengatasi kecemasan yang ada di dalam dirinya agar tidak mengganggu kemampuan berpikir. Penelitian ini bertujuan untuk mengetahui deskripsi kecerdasan emosional dan kesiapan untuk bekerja pada mahasiswa, serta bagaimana kecerdasan emosional memengaruhi kesiapan untuk bekerja pada mahasiswa Program Studi Pendidikan Teknik Bangunan Universitas Pendidikan Indonesia. Metode penelitian yang digunakan adalah metode deskriptif asosiatif dengan pendekatan kuantitatif, dengan teknik pengumpulan data menggunakan kuesioner. Jumlah sampel penelitian adalah 51 mahasiswa, yang terdiri dari mahasiswa Program Studi Pendidikan Teknik Bangunan angkatan 2019. Hasil penelitian yang diperoleh menunjukkan bahwa kecerdasan emosional dan kesiapan untuk bekerja pada mahasiswa Program Studi Pendidikan Teknik Bangunan Universitas Pendidikan Indonesia berada dalam kategori cukup tinggi. Selain itu, terdapat juga pengaruh yang signifikan antara kecerdasan emosional dengan kesiapan untuk bekerja pada mahasiswa Program Studi Pendidikan Teknik Bangunan Universitas Pendidikan Indonesia.
The effectiveness of medical penile rehabilitation after radical prostatectomy
Authors: Pomeshkin E. V. , Popov S. V. , Orlov I. N. , Shamin M. V. , Kagan E. S. 
Published: November 2023

Background. Among the drug methods of penile rehabilitation in patients after nerve-sparing prostatectomy, the use of phosphodiesterase-5 (PDE-5) inhibitors is proposed as the first line of therapy, which have shown high efficiency, ease of use, good tolerability and safety, improving the quality of life of patients.Aim. To evaluate the effectiveness of drug-induced penile rehabilitation after nerve-sparing prostatectomy in the restoration of erectile function (EF) with an analysis of the factors influencing it.Materials and methods. The study included 108 patients with localized prostate cancer who underwent nerve-sparing prostatectomy. All patients were randomized into two groups. In Group 1 patients did not receive drug therapy for the prevention and treatment of erectile dysfunction. In Group 2 patients in the postoperative period received daily PDE-5 inhibitors (tadalafil) at a minimum dosage of 5 mg for 12 months as a drug therapy. Initially and at the annual stage of the study, the state of EF, erectile rigidity, night penile test, and quality of life were assessed. An analysis was also made of the factors affecting the preservation of EF one year after nerve-sparing radical prostatectomy.Results. The best reliable results in terms of maintaining EF at the annual stage of the study were obtained in the group whose patients received postoperative drug therapy with PDE-5 inhibitors. It was possible to identify the most significant factors influencing the state of EF in the postoperative period after radical prostatectomy: the type of operation – bilateral nerve sparing, taking PDE-5 inhibitors, the patient’s age, the presence/absence of diabetes mellitus, the state of EF (International Index of Erectile Function-5 value) before the operation.Conclusion. Daily intake of PDE-5 inhibitors at a low dose of 5 mg is indicated for patients after nerve-sparing prostatectomy as an effective means of penile rehabilitation in order to preserve EF, as it provides better results compared to no drug therapy. Patients who meet criteria such as young age, no diabetes, high preoperative International Index of Erectile Function-5 levels may benefit most from nerve-sparing surgical techniques and early postoperative participation in a penile rehabilitation program for erectile dysfunction.
Complications of testicular prosthetics: analysis of causes, surgical tactics, ways of prevention
Authors: Shormanov I. S. , Shchedrov D. N. , Spasskaya Y. S. , Garova D. Yu. 
Published: November 2023

Background. Testicular prosthetics, despite the apparent simplicity of the technique of performing the operation, often leads to complications. At the same time, the spread of data from different authors on the frequency and structure of complications is extremely large. At the same time, the factors indicated by the authors as the causes of complications often contradict each other, and, as a rule, are not analyzed, therefore, methods of prevention and therapeutic tactics are not clearly defined today.Aim. To analyze the frequency and structure of complications during testicular prosthetics in patients over 18 years of age and adolescent children, as well as to suggest optimal ways to prevent the identified complications.Materials and methods. The results of testicular prosthetics were analyzed in 292 patients aged 12–59 years in the period 2007–2022. Various complications were found in 27 patients (9.24 %), including in the adolescent group (12–17 years) – in 13 (8.33 %) patients out of 156, in adults – in 14 (10.29 %) out of 136. MIT implants were used in 116 cases (adults – 54, adolescents – 62) and Promedon implants – in 176 cases (adults – 80, adolescents – 96). Data processing was carried out in the Statistica 20.0 program. The p <0.05 level was considered statistically significant.Results. The most common complications include implant extrusion (22.2 %) and surgical hemostasis disorders (29.6 %), they are also the most difficult to correct and often lead to the need to remove the implant. The use of antibacterial therapy by the course does not reduce the risk of complications, the absence of antibiotic prophylaxis increases the incidence of complications by 3.9 % in the adult group and by 2.28 % in the adolescent group. The most rational single perioperative antibiotic prophylaxis. The frequency of complications when using MIT implants is higher (n = 17) than Promedon (n = 10). The incidence of complications is significantly higher in the group of patients who underwent prosthetics for more than three years after primary orchectomy or in an initially hypoplasized scrotum.Conclusion. Complications of testicular prosthetics are 8.33–10.29 %. The structure is dominated by complications of hemostasis and implant extrusion, they are also the cause of the greatest number of repeated interventions and the reason for the removal of the implant. A number of factors influence the formation of complications – access, the scheme of antibacterial therapy/prevention, the implantable material, the period after the initial operation. The most rational is the use of a modern silicone implant for prosthetics 6–12 months after orchectomy with suprascrotal access with a single perioperative antibiotic prophylaxis. The risk of the most dangerous and frequent complications can be leveled by using preventive measures.
Effect of aromatase inhibitors on male fertility: literature review
Authors: Epanchintseva E. A. , Selyatitskaya V. G. , Korneev I. A. , Babenko A. Yu. 
Published: November 2023

Aсcording to the Russian Society of Urology the incidence of infertile couples ranges from 8 to 17.2 % in various regions of Russia, while the male factor accounts for about half of all cases, which requires a balanced approach to diagnosing the causes of reduced fertility and selecting personalized therapy. In accordance with the Russian Society of Urology guidelines, gonadotropins, selective estrogen receptor modulators and antioxidants can be used in the treatment of male infertility. According to the European Association of Urologists guidelines and American Urological Association/ American Society for Reproductive Medicine guidelines, this list may also include gonadotropin-releasing hormone and aromatase inhibitors (AI).Research objective: to review up-to-date literature data on effect of IA on male fertility and clarify the place of AI in the treatment of male infertility.The data obtained indicate that AI can increase the concentration, mobility and percentage of normal forms of spermatozoa, reduce sperm DNA fragmentation and normalize protamination processes. These effects were more pronounced in patients with overweight and obesity, as well as in patients with testosterone-to-estradiol ratios of <10. Given the important role of estrogens in spermatogenesis, when using AI, it is advisable to control the hormonal status and prevent estradiol from falling below the reference range, taking into account its multiple effects. However, a lack of quality data causes inability to accurately predict the effect of AI treatment on pregnancy rate and childbirth. Further research is required to formulate recommendations based on evidence for the use of AI for treatment of male infertility, in Russia changes in the instructions for medicines and regulatory documents will be required.
An Evaluation of Age Determination in Forensic Medicine Using Scoring of the Epiphyses at the Knee Joint on Radiographs
Authors: Akkuş Çetinkaya Tuba , Avşar Abdullah , Kızıldağ Betül 
Published: November 2023

Objective:Age estimation is also widely used in identification. The aim of study is to investigate applicability of age determination method in Türkiye by examining the radiographs of the knee joint and using the epiphyseal scoring based on the degree of epiphyseal closure.
Methods: Knee graphs of 676 cases (337 women, 339 men) aged between 10 and 26 years were retrospectively analyzed. Distal femur (DF), proximal tibia (PT), and proximal fibula (PF) epiphyseal lines were evaluated separately in each case. The closure of the epiphyses was studied at 3 stages. DF, PT and PF epiphyses were graded 0, 1, 2 for stage 1, 2 and 3 respectively. These three scores obtained in each case were collected and the score of the epiphyses at the knee joint (SKJ) was obtained.
Results: The median age in each of the SKJs increased in both men and women. The difference between the genders was statistically significant according to the median age of 0-5 points (p<0.001). As a result of the receptor operating characteristic curve analysis, the highest accuracy value was found to be 6 points in both genders. In males, the sensitivity was 0.989, the specificity was 0.880, and the overall accuracy was 0.943. In females, these values were found to be 1.000 for sensitivity, 0.648 for specificity, and 0.845 for overall accuracy.
Conclusion: The study suggests that knee joint epiphyseal scoring is a simple and practical method with high inter-rater agreement in determining whether a Turkish individual is older than 18 years of age.
Desensitization for the Prevention of Drug Hypersensitivity
Authors: Yun Jeong-Eun , Jeong Jiung , Kang Hye-Ryun 
Published: November 2023

Drug desensitization is a treatment strategy for patients with hypersensitivity to essential drugs without alternatives. The gradual increase in the drug dosage from low doses to therapeutic levels induces a transient immune tolerance to the culprit drug. Although desensitization has traditionally been recommended for IgE-mediated immediate hypersensitivity, this indication has recently been expanded to include non-IgE-mediated immediate responses, nonimmunological responses, and T-cell mediated delayed hypersensitivity reactions. Although the exact mechanism behind desensitization remains unclear, the process is thought to attenuate various intracellular signals in target cells through the high-affinity IgE receptor (FcɛRI) internalization, alteration in signaling pathways in mast cells and basophils, reduction in Ca2+ influx, and production of anti-drug IgG4 blocking antibody. Desensitization can be used for the safe administration of anti-neoplastic agents, antibiotics, aspirin, and nonsteroidal anti-inflammatory drugs. Various desensitization protocols have been proposed for each drug. The optimization of drug concentration, target dosage, administration interval, and route of administration is key to successful desensitization. In addition, the desensitization protocol should be individualized for each patient with consideration of the severity of the initial hypersensitivity response, the characteristics of the culprit drug, and the nature of the breakthrough reactions.
Development of Novel Drugs to Promote Functional Recovery After Brain Injury
Authors: Nakajima Waki , Takahashi Takuya 
Published: November 2023

The central nervous system injury such as stroke can severely cause motor paralysis.Although the approach of rehabilitative training is developed, many patients still face restrictions in their daily living after rehabilitation. Thereby, a new compound with a strong potential to enhance motor function recovery with rehabilitation is an unmet medical need. We focus on the one of glutamate receptors, the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, which plays an important role in learning and memory. Here, we found a novel small low molecular compound, edonerpic maleate, that facilitated experience-dependent synaptic AMPA receptor delivery in the barrel cortex and dramatically accelerated motor function recovery after brain damage in a rodent model. Furthermore, edonerpic maleate enhanced the upper limb function recovery of macaque monkeys with internal capsule hemorrhage. Currently, a phase 2 clinical trial is being conducted to verify the efficacy of edonerpic maleate in stroke patients and has attracted global attention.
Response of Renal Intercalated Cells to Dietary Potassium Intake
Authors: Lee Su-Youn , Han Ki-Hwan 
Published: November 2023

Compared to ancient humans who consumed enough potassium (K+ ), modern humans seem to have taken in inadequate K+ . The renal collecting duct plays an important role in regulating K+ homeostasis. There are at least three different types of cells in the collecting duct. The purpose of this study is to examine the effects of dietary K+ intake on collecting duct intercalated cells. C57BL/6 mice had free access to a control (1%), low (<0.01%), or high (5%) K+ diet for 1 week. Kidney tissue were processed for immunohistochemistry, light microscopy, and image analysis. Excessive dietary K+ intake or deficiency significantly changed blood K+ concentrations in mice. The size of type A intercalated cells increased by about 1.6 times in the low K+ group and decreased in the high K+ group. Conversely, the size of type B intercalated cells decreased in the low K+ group and increased in the high K+ group. The response of NANB cells to dietary K+ intake was generally similar to that of type B cells. These results demonstrated that renal intercalated cells vary greatly with dietary K+ intake. The structural changes in response to K+ imbalance may be closely related to cardiovascular and renal disorders in modern humans.
Therapeutic Effect of Atorvastatin on Interleukin-13- Induced Lung Pathology
Authors: Mo Yosep , Bae Boram , Kim Junghyun , Kim Ruth Lee , Son Kyunghee , Kang Min-Jong , Lee Chun-Gen , Cho Sang-Heon , Kang Hye-Ryun 
Published: November 2023

PPurpose: Asthma is a common chronic lung disease, in which interleukin (IL)-13 is implicated as a central regulator of IgE synthesis, mucus hypersecretion, airway hyperresponsiveness (AHR), and fibrosis. This study was designed to determine the anti-inflammatory effect of atorvastatin, a widely used lipid-lowering agent, on IL-13-induced lung pathology through the modulation of macrophages. Methods: Atorvastatin (40 mg/ kg) was given to transgenic mice overexpressing IL-13 (IL-13 TG mice) and their wild type littermates by oral gavage for 2 weeks. AHR, the number of inflammatory cells in the airway, and cytokine levels in IL-13 TG mice were measured. Using the alveolar macrophage (AM) cell line CRL-2456, the direct effect of atorvastatin on macrophages activated by recombinant IL-13 was assessed. Results: Significant reduction in total leukocytes and alleviation of AHR were observed with the administration of atorvastatin in IL-13 TG mice compared to those without atorvastatin treatment (P < 0.05). Atorvastatin administration resulted in the upregulation of IL-10 in the lungs of IL-13 TG mice (P < 0.05). In addition, mRNA expression of connective tissue growth factor, fibronectin, and type III collagen as well as chord length enhanced by IL-13 overexpression were reduced by atorvastatin administration (P < 0.05). M2 macrophage markers were decreased, while the M1 macrophage marker was increased upon atorvastatin treatment (P < 0.05). Administration of atorvastatin resulted in improved removal of apoptotic cells (P < 0.05). Conclusion: The results of this study reveal the potential of atorvastatin as an effective anti-asthmatic agent by reducing IL-13-induced lung inflammation via the modulation of macrophage polarization.
A Single Nonsteroidal Anti-Inflammatory Drugs-Induced Anaphylaxis to Diclofenac Confirmed by Skin Testing
Authors: Hana Lee  , Jung-Hyun Kim  , Yong-Hyun Kim  , Bomi Seo  , Sae-Hoon Kim  , Yoon-Seok Chang  
Published: November 2023

Anaphylaxis is a serious acute systemic allergic reaction that can lead to death, thus requiring immediate diagnosis and treatment. In particular, food is the most common cause of anaphylaxis in children, adolescents, and young adults. In addition to physical contact with food, anaphylaxis can also be induced by exposures other than ingestion, such as the inhalation of aerosolized food proteins. Korean males undergo medical screening prior to a compulsory military service. A history of possible food allergy requires referral to a specialized allergy clinic. It was reported in 2021 that a 19-year-old male patient enlisted in the military was referred to the allergy clinic for an oral provocation test. That case confirmed that anaphylaxis was caused not only by walnut intake, but also by skin contact or by inhaling walnut particles, which will be reviewed in this paper.