bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pilot study proposing an algorithm for pubertal induction in cerebral palsy
Authors: Trinh Anne , Lim Angelina , Wong Phillip , Brown Justin , Pitkin Janne , Wollenhoven Beverley , Ebeling Peter , Fuller Peter , Milat Frances , Zacharin Margaret 
Published: February 2024

Abstract

Objectives
To explore delayed puberty in cerebral palsy (CP) and to test the acceptability of an interventional puberty induction algorithm.

Methods
A two phase cohort study in children and adolescents diagnosed with CP who have delayed puberty. Phase 1: Retrospective review of clinical records and interviews with patients who have been treated with sex-steroids and Phase 2: Prospective interventional trial of pubertal induction with a proposed algorithm of transdermal testosterone (males) or oestrogen (females). Phase 1 examined experiences with sex-steroid treatment. Phase 2 collected data on height adjusted bone mineral density (BMAD), fractures, adverse effects, mobility and quality of life over two years during the induction.

Results
Phase 1, treatment was well tolerated in 11/20 treated with sex-steroids; phase 2, using the proposed induction algorithm, 7/10 treated reached Tanner stage 3 by nine months. One participant reached Tanner stage 5 in 24 months. Mean change in BMAD Z-scores was +0.27 % (SD 0.002) in those who could be scanned by dual-energy X-ray absorptiometry (DXA).

Conclusions
Delayed puberty may be diagnosed late. Treatment was beneficial and well tolerated, suggesting all patients with severe pubertal delay or arrest should be considered for sex hormone supplementation.
The strategic jump-the order effect on winning “The Final Three” in long jump competitions
Authors: Karlsson Niklas , Lunander Anders 
Published: February 2024

Abstract
The tournament rules for long jump competitions have changed in recent years. Today, only the three athletes with the best jumps from the five initial attempts are qualified to make an additional sixth jump – a format called The Final Three. In the first implemented version of The Final Three, the top athletes sequentially make one final jump, starting with the athlete ranked third place from the initial attempts. The athlete with the longest jump in this sixth attempt wins the competition, irrespective of achieved results in previous attempts. In this study, we analyze the effect of the athletes’ jump order on the probability of winning the competition within this first implemented version of The Final Three. We derive the final’s symmetric subgame perfect equilibrium and compute the corresponding equilibrium winning probabilities, given estimated distributional parameters from the Olympic long jumping final in Tokyo 2021. The modeling of the game is preceded by a development of a stochastic model for the outcome in long jumping. Our results indicate a last mover advantage, albeit small. Our model also reveals the importance of having a low variation in the approach run length and thinking strategically in this tournament format.
Characterization of microstructure and magnetic properties of 3D printed bonded magnets made by fused deposition modeling
Authors: Brunčko M. , Kneissl A. C. , Gorše L. , Anžel I. 
Published: February 2024

Abstract
Bonded magnets are composite materials consisting of polymer matrix and magnetic powders, prepared by rapid solidification processes from Nd-Fe-B alloys. They are synthesised by the compounding process on a twin-screw extruder, whereby, the finished products of complex shapes can be made from bonded magnets using injection moulding or 3D printing by fused deposition modelling method (FDM). The main advantages of 3D printing are the possibility to produce parts with complex geometries that are not possible with traditional manufacturing techniques and low-cost production of small batches.
The aim of the research work was to identify the optimum processing parameters, which would give 3D printed bonded magnets characteristics similar to those produced by injection moulding. The characterization of the microstructure of bonded magnets was made on cryo-fractured, conventionally mechanically prepared and ion beam polished samples. The microstructures of bonded magnets were analysed by stereo, optical and scanning electron microscopy. Additionally, the influence of the 3D printing parameters on the magnetic properties has been examined.
The results of the research work have shown that desired magnetic properties of 3D printed bonded magnets can be obtained by optimizing the thickness of the printed layer, printing speed and flowrate. In addition, it was revealed that selection of the materialographic preparation method plays a crucial step for correct microstructural characterization. Namely, the impropriate sample preparation results in artifacts that are mostly misinterpreted as microstructural defects (pores, cracks, non-adherent layers, etc.) accidently caused during 3d printing.
Studije Božidara Gagre u katalozima „decenijskih izložaba” Muzeja savremene umetnosti u Beogradu
Authors: Prelog Petar 
Published: February 2024

U ovom radu analizirat će se tri studije hrvatskog povjesničara umjetnosti Božidara Gagre objavljene u katalozima „decenijskih izložaba” Muzeja savremene umetnosti u Beogradu. Prva (1972.) predstavlja početke hrvatskog modernog slikarstva kao niz spram neposrednoj prošlosti kritički usmjerenih iskaza, obilježenih individualizmom i u uskoj vezi s društvenom situacijom. Druga (1975.) pak obrađuje hrvatsku skulpturu u dugačkom razdoblju od osam desetljeća (1870. – 1950.): analizira se njezina uloga u modernom građanskom društvu te se detektiraju kiparski naraštaji i njihovi nositelji. U trećoj studiji (1977.) Gagro pruža sintezni pregled hrvatske grafike u prvoj polovini 20. stoljeća, raspravljajući prije svega o njezinu društvenom položaju. U autorovu pristupu prepoznat će se tako utjecaji one metodološke struje povijesti umjetnosti koja je umjetničku produkciju promatrala kao jasan odraz društvenih okolnosti. Ocijenit će se zatim povijesnoumjetnički prinosi tih studija, a zaključno istaknuti i obilježja Gagrine valorizacijske paradigme koja je europskim kanonskim vrijednostima pridavala značenje važne orijentacijske točke, a ne nedostižnog cilja.
Characteristics of Sudden Unexpected Infant Deaths on Shared and Nonshared Sleep Surfaces
Authors: Erck Lambert Alexa B. , Shapiro-Mendoza Carrie K. , Parks Sharyn E. , Cottengim Carri , Faulkner Meghan , Hauck Fern R. 
Published: February 2024

OBJECTIVES
Describe characteristics of sudden unexpected infant deaths (SUID) occurring on shared or nonshared sleep surfaces.

METHODS
We examined SUID among residents of 23 US jurisdictions who died during 2011 to 2020. We calculated frequencies and percentages of demographic, sleep environment, and other characteristics by sleep surface sharing status and reported differences of at least 5% between surface sharing and nonsharing infants.

RESULTS
Of 7595 SUID cases, 59.5% were sleep surface sharing when they died. Compared with nonsharing infants, sharing infants were more often aged 0 to 3 months, non-Hispanic Black, publicly insured, found supine, found in an adult bed or chair/couch, had a higher number of unsafe sleep factors present, were exposed to maternal cigarette smoking prenatally, were supervised by a parent at the time of death, or had a supervisor who was impaired by drugs or alcohol at the time of death. At least 76% of all SUID had multiple unsafe sleep factors present. Among surface-sharing SUID, most were sharing with adults only (68.2%), in an adult bed (75.9%), and with 1 other person (51.6%). Surface sharing was more common among multiples than singletons.

CONCLUSIONS
Among SUID, surface sharing and nonsharing infants varied by age at death, race and ethnicity, insurance type, presence of unsafe sleep factors, prenatal smoke exposure, and supervisor impairment. Most SUID, regardless of sleep location, had multiple unsafe sleep factors present, demonstrating the need for comprehensive safe sleep counseling for every family at every encounter.
Influence of Soil Tillage Systems on Rapeseed Production Parameters and on the Numerical Density of Pest Complex
Authors: HORGA Vasile-Adrian , ȘTER Vlăduț-Ionuț , SUCIU Dan-Laurențiu , HULUJAN Ionuț-Bogdan , FLORIAN Teodora , RUSU Teodor 
Published: February 2024

Brassica rapa L. is one of the most common plant cultivated in Europe. The farmers from Ungheni area (Mureș, Romania) reported the attack of pest complex in rapeseed culture in the 2021 year. For that, two soil tillage systems were estabilished to reduce the pests complex and to increase the rapeseed production. The results indicated that is recommanded to apply two different tillage sistems at 5 parcels. First ot them was the conventional tillage, with plough and the other one was reduced tillage, with cultivator. For monitoring the growth stage and the pests percentage, 20 rapeseed plants were selected from each parcel. The pests idenification taked place at the Entomology Discipline and the plants grown stage and production parameters were analyzed at Agrotehnical Discipline, at University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca. In the conventional tillage the average of plants reported with pests was about 55% and the maximum number of adults/plant was 7 (field 2). In the minimum tillage, the average of plants reported with pests was about 15 % and the maximum number of adults/plant was 2. In the fields with plough, the production was about 3200 kg/ha and in those with cultivator, the production was about 4400 kg/ha.
Preliminary Results Regarding the Behaviour of Two Chokeberry (Aronia melanocarpa Michx.) Cultivars in Environmental Conditions of Northern Transylvania
Authors: CHIOREAN Anca Maria , ROȘU-MAREȘ Smaranda , JAKAB- ILYEFALVI Zsolt , BUTA Erzsebet , MITRE Viorel 
Published: February 2024

The paper presents preliminary results of the behaviour of two Aronia cultivars grown conventionally and organically. Aronia melanocarpa Michx. Elliott is a versatile, deciduous ultistems shrub, which belongs to Rosaceae family. It is considered a rustic shrub due to its high capacity to adapt to different geographic areas, climatic conditions (temperature, rainfall, humidity) and various soil types. It originates from North America and Canada, chokeberry fruits have the highest antioxidant, polyphenols, anthocyans and vitamins content among many shrub species. ‘Nero’ and ‘Melrom’ chokeberry cultivars, found favourable environmental conditions for growth and fruit production in Northern Transylvania, with an average bush volume between 0.46m³- 0.84m³ and yield between 1.018t/ha- 1.674t/ha, in the first 3 years after planting.
Comparative Effects of Vitamin A and E Dietary Supplements on Semen Traits, Reproductive System Morphology and Vitamin Storage in Rooster
Authors: ȘIPOTENU Diana Andreea , MOGOȘ George , CIOBOTARU Emilia , CIOARIC Mădălina , BĂLĂCEANU Rosalie , DOJANĂ Nicolae 
Published: February 2024

The purpose of this study was to determine the effect of long-term vitamin A and E dietary supplements on the semen traits and morphology of the reproductive system in older roosters to prolong their reproductive contributions to the flock. The research revealed that long-term dietary supplementation of both vitamins A and E maintained the traits of the semen at levels significantly higher than in the control roosters. Vitamin A especially maintained ejaculate volume and semen density, while vitamin E protected semen motility and viability. Vitamin A treatment maintained the uniformity of the epididymal epithelium. No eroded areas were identified in this epithelium. Most epithelial cells were principal cells with uniform stereocilia. The connective tissue which lines the epididymal tubule of the vitamin A treated rooster was thinner than those of the roosters from the control. Vitamin E predominantly protected the structure of the spermatogenesis line. Liver tissue concentrations of vitamins A and E were two times and four times higher respectively than the control. The two vitamins were eliminated in increased quantities through the seminal plasma in supplemented roosters. No mutual inhibition or potentiating effects were found between the two vitamins, suggesting that their combined administration should be further analyzed.
Comparitive analysis of palatal rugae in tribal and urban population of Madhya Pradesh
Authors: Gupta Bhavana , Pandey Poonam 
Published: February 2024

Human identification is a major task undertaken in forensic sciences. The study of palatine rugae and the study of fingerprints are sometimes complementary and based on same scientific basis.The palatal rugae patterns are unique to every individual and are protected by the lips, buccal pad of fat and teeth. This study was conducted to examine shape and pattern of palatal rugae between tribal population and urban population of M.P state. : The study sample consisted of 60 subjects, 30 each from tribal(Gond) and urban population of Madhya Pradesh, in the age group ranging from 18 to 25 yrs. The impression of maxillary arch was obtained from each subject using alginate impression material and cast were made. The rugae were delineated on the cast using a sharp graphite pencil under adequate light and magnification and recorded according to classification given by Thomas and Kotze (1983). : After analyzing the rugae patterns in both the groups and between the 2 sides of the palate, the wavy pattern was found to be predominant followed by curved, straight, unification, circular, and nonspecific in decreasing order in the overall population. There was an obvious difference between the Rugae shapes in tribal (gonds) and urban population of Bhopal city. No significant difference in number of rugae between right and left sides between the primary and secondary rugae patterns were observed. : The pattern of rugae was seen different in these ethnic groups. In the present study, significant difference exists between the rugae patterns in tribals and urban population of M.P.
Konfederacja warszawska w trzech bezkrólewiach poprzedzających rządy kolejnych monarchów z dynastii Wazów w Rzeczypospolitej
Authors: Kempa Tomasz 
Published: February 2024

Przyjęty podczas bezkrólewia w 1573 r. akt konfederacji warszawskiej gwarantował swobodę wyznania wszystkim chrześcijanom (szlachcie i przynajmniej mieszczanom miast królewskich) w Rzeczypospolitej. Oznaczało to równą pozycję prawną katolików, prawosławnych oraz protestantów różnych wyznań, łącznie z odrzucającymi dogmat o Świętej Trójcy braćmi polskimi. Z tego powodu akt ten był od początku kontestowany przez biskupów katolickich w Rzeczypospolitej i zwalczany przez papiestwo. Akt konfederacji zawierał tylko ogólne sformułowania i dlatego, jak się okazało, nie stanowił skutecznej ochrony niekatolików przed skierowanymi przeciw nim tumultami, których nasilenie przypadło na ostatnie kilkanaście lat XVI wieku. Niekatolicy starali się zatem o uchwalenie ustaw, które precyzowałyby sposób karania sprawców takich ataków z powodów wyznaniowych, a także szczegółowo przedstawiały prawa różnowierców. Opór przeciwko takim konkretnym rozwiązaniom prawnym po stronie katolickiej okazał się duży. Dlatego niekatolicy, a zwłaszcza protestanci, mobilizowali się do walki sejmowej w okresie bezkrólewi, w czasie których – jak się wydawało – łatwiej było wprowadzić nowe rozwiązania prawne. Z tego powodu zasadne jest porównanie trzech kolejnych bezkrólewi (1586/87, 1632/33, 1648/49) w kontekście walki różnowierców o potwierdzenie konfederacji warszawskiej. Porównanie to wyraźnie pokazuje coraz słabszą realną pozycję niekatolików w Rzeczypospolitej, mimo formalnego potwierdzania aktu konfederacji, w pierwotnej, ogólnikowej wersji. W dwóch ostatnich bezkrólewiach jednocześnie uchwalano przy tym między innymi zakaz budowy nowych zborów w miastach królewskich, a także próbowano wykluczyć braci polskich spod ochrony, jaką zapewniała konfederacja. W przeciwieństwie do bezkrólewia z 1587 r., w czasie dwóch kolejnych bezkrólewi nie było już katolików, którzy podczas obrad sejmowych wspieraliby niekatolików w ich postulatach.
Exosomes Derived from Heat‐shocked Tumor Cells Promote In vitro Maturation of Bone Marrow-derived Dendritic Cells
Authors: Heidari Neda , Abbasi-kenarsari Hajar , Niknam Bahare , Asadirad Ali , Amani Davar , Mirsanei Zahra , Hashemi Seyed Mahmoud 
Published: February 2024

Dendritic cells (DCs), professional antigen-presenting cells that process and deliver antigens using MHC II/I molecules, can be enhanced in numerous ways. Exosomes derived from heat‐shocked tumor cells (HS‐TEXs) contain high amounts of heat-shock proteins (HSPs). HSPs, as chaperons, can induce DC maturation. This study aimed to investigate whether HS‐TEXs can promote DC maturation.
To generate DC, bone marrow-derived cells were treated with Interleukin-4 and GM-CSF. Exosomes were isolated from heat-treated CT-26 cells. The expression level of HSP in exosomes was checked by western blot and the increase in the expression of this protein was observed. Then, HS‐TEXs were co-cultured with iDCs to determine DC maturity, and then DCs were co-cultured with lymphocytes to determine DC activity.
Our results showed that DCs treated with HS‐TEXs express high levels of molecules involved in DC maturation and function including MHCII, CD40, CD83, and CD86. HS‐TEXs caused phenotypic and functional maturation of DCs. In addition, flow cytometric results reflected a higher proliferative response of lymphocytes in the iDC / Tex + HSP group.
HS‐TEXs could be used as a strategy to improve DC maturation and activation.
Virtual reality among dental patients – cross-sectional, questionnaire, pilot study
Authors: Ledwoń Anna , Dębski Paweł , Jędrusik Przemysław , Skucha-Nowak Małgorzata , Mikusek Jakub 
Published: February 2024

WstępStrach przed wizytą stomatologiczną jest poważnym problemem zarówno u dzieci, jak i u pacjentów dorosłych. Często staje się on przyczyną unikania wizyt, co może skutkować pogorszeniem nie tylko zdrowia jamy ustnej, lecz także całego organizmu. Istnieje wiele metod mających na celu zrelaksowanie i uspokojenie pacjenta przed samą wizytą oraz w jej trakcie. Wykorzystanie wirtualnej rzeczywistości stanowi jedną z nich.Materiał i metodyBadanie pilotażowe przeprowadzono w grupie 100 dorosłych pacjentów, podczas gdy oczekiwali na wizytę stomatologiczną w poczekalni. Ankietowani wypełniali dobrowolny kwestionariusz wielokrotnego wyboru składający się z czterech pytań.WynikiWyniki pokazują, że najczęściej wybieranymi odpowiedziami były projekcja krajobrazów (40%) oraz interaktywny spacer, np. po plaży, lub trekking w górach (35%). Nie zaobserwowano różnic w zależności od płci. Zarówno mężczyźni, jak i kobiety najczęściej wybierali projekcję krajobrazów. Zdecydowana większość ankietowanych (87%) była skłonna skorzystać z dystrakcji z wykorzystaniem wirtualnej rzeczywistości podczas wizyty stomatologicznej. Pozostałe 13% pacjentów nie chciało w ogóle korzystać z wirtualnej rzeczywistości, niezależnie od proponowanego materiału audiowizualnego.WnioskiWiększość pacjentów była optymistycznie nastawiona do skorzystania z wirtualnej rzeczywistości podczas wizyty stomatologicznej. Najczęściej wybierane odpowiedzi były związane ze spokojnymi oraz relaksującymi materiałami niż z grami czy quizami. Badanie wskazuje, że pacjenci stomatologiczni są skłonni korzystać z nowoczesnych technologii w walce z dentofobią.
Study on Shear Slip Characteristics of Sandstone Plane Joints under Normal Dynamic Load Disturbance
Authors: Wang Kangyu , Lu Caiping , Liu Yang , Shao Caijun , Zhou Jian , Zhan Zhaowei 
Published: February 2024

Abstract
Rock joints are susceptible to slip instability due to dynamic load disturbances such as blasting, earthquakes, and fracturation. A series of direct shear tests under the dynamic load were conducted on sandstone plane joints using the RDS-200xl. The work investigated the effects of normal static loads and normal dynamic-load frequencies and amplitudes on plane joints. Besides, the following items were proposed, that is, the peak-to-valley response rate, shear velocity vibration dominant frequency, shear-stress reduction coefficient, and discrete element numerical simulation method for plane-joint direct shear tests. The results were as follows: (1) The normal dynamic load frequency played a role in attenuating the shear stress amplitude with a threshold value of 0.5 Hz. (2) The shear velocity of the plane joint was completely controlled by the high normal dynamic load frequency. Their vibrational dominant frequencies were identical. (3) The amplitude of shear stress increased, and the median stress decreased with the increased normal dynamic load amplitude. The reduction-coefficient equation for sandstone plane joints was proposed to evaluate the shear stress under the normal dynamic load disturbance. (4) The shear-stress hysteresis phenomenon existed in the plane joints under the normal dynamic load, which required excessive shear displacements to reach peak shear strength. The peak shear displacement increased with the increased normal static load. Numerical simulations and indoor tests showed that high- and low-shear-velocity regions were the main reason for shear-stress hysteresis. The findings are conducive to revealing the shear destabilization mechanism of rock joints under dynamic load disturbance.
Small RNA activation of CDH13 expression overcome BCR-ABL1-independent imatinib-resistance and their signaling pathway studies in chronic myeloid leukemia
Authors: Fei Jia , Su Rui , Wang Xiuyuan , Wen Ziqi , Zhan Xinri , Li Chuting , Yin Zhao , Liu Yanjun , Yang Juha 
Published: February 2024

Abstract

BCR-ABL1-independent resistance to imatinib has no effective treatment due to its complexity and diversity. We previously reported that the CDH13 oncogene was expressed at low levels in BCR-ABL1-independent resistant CML cell lines. However, its effects on CML resistant cells and mechanisms remain unknown. This study investigated the effects of saRNA-based CDH13 activation on BCR-ABL1-independent imatinib resistance in CML and its underlying mechanism, and proposes a unique treatment method to overcome imatinib resistance. Specifically, this study demonstrated that using the DSIR (Designer of Small Interfering RNA) website tool, saRNAs targeting the CDH13 promoter region were generated and validated using qPCR and western blotting. Among the predicted sequences, C2 and C3 efficiently elevated CDH13 mRNA and protein expression, as well as inhibited the relative vitality of cells and the ability to form clones. After promoting CDH13 expression in K562-IMR cells, it inhabited the NF-κB signaling pathway and induced apoptosis in imatinib-resistant CML cells. LNP-saRNA (C3) was also observed to limit the growth of K562-IMR cells in vivo. From the above, the activation of CDH13 expression by saRNA promotes cell apoptosis by inhibiting the NF-κB signaling pathway to overcome to BCR-ABL1-independent resistance to imatinib in patients with CML.