bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole grain products in children nutrition
Authors: Pyrieva E. A. , Safronova A. I. , Georgieva О. V. 
Published: November 2023

The article discusses the problems of using products containing whole grains in the nutrition of young children. Among the most controversial are the issues of the optimal quantity and timing of inclusion of the whole grain component in baby food. The results of studies are presented confirming the effectiveness of including whole grains in children’s diets, as well as the level of their consumption in the world, demonstrating significant national differences (from 2 to 58 g per day). In general, despite the obvious benefits of whole grains, actual consumption of whole grains by children is not enough to realize their health potential. As one of the ways to solve the problem, the early inclusion of whole grains in the diet, starting from the first year of life, is considered. Aspects that limit the use of whole grains in nutrition are noted inconsistency in the identification of whole grain products and their sanitary and hygienic safety. Currently, both 30 and 50% have been proposed as the level of whole grain content in a product that allows it to be classified as whole grain. The issue of safety is especially relevant for baby food, since the outer layers of grains can concentrate contaminants (heavy metals, mycotoxins, arsenic, pesticides). It has been established that the arsenic content in whole rice products is higher than in refined analogues. In this regard, specialized baby food products have advantages for organizing nutrition for young children, the production of which involves special approaches to the selection of whole grain raw materials and technological processing modes to ensure the requirements for its quality and safety. Domestic and foreign documents regulating the requirements for safety indicators for specialized grain-based products for baby food are presented.
Sarcopenia and malnutrition in patients with liver diseases
Authors: Ostrovskaya A. S. , Maevskaya M. V. 
Published: November 2023

This review focuses on the most current information on the pathogenesis, diagnosis and treatment of sarcopenia and malnutrition in patients with liver disease. Sarcopenia and malnutrition are common complications of liver diseases. Liver cirrhosis, as a stage of the pathological process, serves as the main predisposing factor for the development of malnutrition and sarcopenia. The frequency of sarcopenia in liver cirrhosis is 30–50% and reaches 100% in decompensated patients. The main pathogenetic links are: impaired proteostasis of skeletal muscles, systemic inflammation and changes in gut microbiota. In recent years, enough data have been accumulated to consider these conditions as a prognostically unfavorable factor in patients with liver cirrhosis of various etiologies, affecting their quality of life and survival, as well as worsening the out-comes of transplantation. This dictates the necessity to define unified approaches to diagnostics and correction of these conditions. Currently, tests are used for diagnosis, which allow to assess muscle strength and function. Muscle mass is assessed using instrumental methods by measuring individual muscles and calculating skeletal muscle indices. In patients with liver cirrhosis and concomitant sarcopenia and malnutrition, nutritional and lifestyle modification strategies are applicable for correction in addition to therapy aimed at elimination of the etiologic factor. The aim of the review is to evaluate the problems of diagnosis and effective treatment of malnutrition and sarcopenia in patients with liver disease based on literature data. The article presents an overview of the main strategies for the approach, diagnosis and correction of these conditions.
Pharmacogenetic markers of toxicity of FOLFOX/XELOX chemotherapy in patients with gastrointestinal tumors: a prospective observational study
Authors: Fedorinov D. S. , Lyadov V. K. , Abdullayev Sh. P. , Kachanova A. A. , Heydarov R. N. , Shashkov I. A. , Mikhailovich V. M. , Surzhikov S. A. , Lyadova M. A. , Sychev I. V. , Galkin V. N. , Poddubnaya I. V. , Sychev D. A. 
Published: November 2023

Introdiction. Systemic chemotherapy (CT) based on oxaliplatin, 5-fluorouracil, capecitabine is the standard of treatment for advanced gastric, colorectal and rectal cancer, which is characterized by frequent development of severe adverse events (AEs). The results of translational studies in the Russian patient population are limited, it is necessary to study pharmacogenetic markers. Aim. To study the frequency of carrying allelic variants of DPYD, GSTP1, MTHFR, XPC, ERCC1, TYMS genes and their association with the development of AEs during palliative treatment with FOLFOX/XELOX.Materials and methods. A total of 166 patients (67 gastric cancer, 99 colorectal cancer) were included in the prospective observational study. All patients underwent pharmacogenetic testing by hybridization analysis on biological microarrays (DPYD (rs2297595 and rs75017182), MTHFR (rs1801133), XPC (rs2228001), TYMS (rs11280056), ERCC1 (rs3212986)) and PCR (GSTP1 (rs1695), ERCC1 (rs11615)) before starting CT. The genotype frequency distribution was analyzed between the groups of patients with and without the development of severe AEs.Results. AEs developed in 97.7% of patients, severe AEs accounting for 54.2%. According to the results of univariate analysis, TC genotype of DPYD gene rs2297595 OR = 3.0 (95% CI 1.2–7.3, p = 0.025), GG genotype of GSTP1 gene rs1695 OR = 2.9 (95% CI 1.02–8.6, p = 0.038) were associated with the development of severe neutropenia. In multivariate analysis TT genotype rs2297595 of the DPYD gene remained the only predictor of severe neutropenia (B ± SE = -1.103 ± 0.503; DI [-2.090; -0.116]; p = 0.028).Conclusions. The results of this study allowed us to identify possible markers of toxicity of FOLFOX/XELOX chemotherapy.
Features of the fatty acid profile of erythrocyte membranes in patients with fatty liver disease of alcoholic genesis
Authors: Kruchinina M. V. , Parulikova M. V. , Belkovets A. V. , Nikolaev K. Yu. , Ovsyannikova A. K. 
Published: November 2023

Introduction. Alcoholic steatosis, which is a reversible condition, is currently considered a significant risk factor for the progression of diffuse liver pathology, therefore understanding of its mechanisms at the molecular level is essential.Aim. To study the features of the fatty acid profile of erythrocyte membranes in patients with fatty liver disease of alcoholic origin for possible use of fatty acids (FAs) as biomarkers and potential therapeutic targets.Materials and methods. A total of 31 men with alcoholic fatty liver disease (AFLD) (average age of 45.1 ± 17.1 years) and 28 men of comparable age without AFLD and symptomatic pathology of internal organs were examined. The FA composition and levels of erythrocyte membranes (ER) were studied using Agilent 7000B (USA) triple quadrupole gas chromatography/mass spectrometry.Results and discussion. A higher level of a range of saturated FAs (lauric, margaric, pentadecane), monounsaturated FAs (MUFAs), which are additional factors for the progression of AFLD (palmitoleic, total monounsaturated acids), n-6/n-3 polyun-saturated FAs ratio (PUFAs), alpha-linolenic FA was detected in patients with AFL vs the control group (p = 0.00002–0.05). In contrast, the levels of arachidic and docosahexaenoic acids, total eicosapentaenoic and docosahexaenoic n-3 PUFAs, and total n-3 PUFAs were lower in patients with AFLD than in healthy men (p = 0.003–0.01), which is associated with increased ethanol induced adipose tissue lipolysis via PDE3B-AMPK axis. The use of FAs panel (C16:1;9, sum MUFA, n-6/n-3 PUFA, C22:6n3, C20:0) to distinguish patients with AFLD from healthy ones ensured high levels of sensitivity (79%), and specificity (81%) (AUC 0.808). Multidirectional associations of FA levels in erythrocyte membranes with each other and liver tests and lipid profile results were revealed.Conclusion. Thus, the features of erythrocytes membrane FAs in patients with AFLD and the potential to use them as biomarkers for differentiation of people with AFLD from healthy individuals have been identified.
Characteristics of nutritional status in patients with chronic kidney disease
Authors: Tishkina S. V. , Shemenkova V. S. , Konstantinova E. V. 
Published: November 2023

Chronic kidney disease is kidney damage that persists for three months or more due to the action of various etiological factors, the anatomical basis of which is the process of replacement of normal anatomical structures with fibrosis, leading to its dysfunction. This nosology is quite common in the modern world; it can progress and lead to disability of patients and a decrease in their quality of life. The mortality rate for this disease also remains high. About 3/4 of patients with this pathology have a terminal stage of the process, which is characterized by the development of protein-energy deficiency (due to uremia, malnutrition, acidosis and persistent inflammatory process), which significantly worsens the prognosis. Currently, the available literature contains a small number of works devoted to this problem, therefore an important part of the management of patients with chronic kidney disease (especially those on hemodialysis) is the assessment and correction of nutritional status. In this article, the authors highlight aspects of the development of protein-energy malnutrition, its possible methods of diagnosis and correction. Electrolyte disturbances, especially hyperkalemia and hyperphosphatemia, are also common complications of chronic kidney disease. Correction of these conditions, in turn, can lead to the development of deficiency of vitamins and other microelements. According to studies presented in the literature, nutritional status is one of the main factors determining the survival and degree of rehabilitation of patients on renal replacement therapy, as well as the effectiveness of dialysis treatment. Thus, a clinician’s knowledge of the nutritional status of this group of patients can improve their prognosis and quality of life.
Influence of mixing conditions on coagulant recovery efficiency and quality
Authors: Ramos da Silva Bruno Moreno , Bastos Rafael Kopschitz Xavier , Godinho Thiago José Dias 
Published: November 2023

Abstract
In this work, the influence of mixing conditions on aluminium recovery from alum sludge and on the recovered coagulant (RC) quality was investigated using acidic treatment. The response surface methodology with a Face Centred Design was used to evaluate the effects of velocity gradient and mixing time on aluminium recovery efficiency, and on the chemical oxygen demand (COD), total suspended solids (TSS) and total phosphorus contents of the RC. No significant effects of both mixing intensity and mixing time on aluminium recovery efficiency were observed; however, these factors significantly affected the quality of the RC in terms of COD, TSS and total phosphorus. The higher velocity gradient increased COD and TSS and the longer mixing time increased phosphorus and TSS in the RC. Operational conditions velocity gradient = 100 s−1 and mixing time = 5 minutes) for aluminium recovery were suggested on economic basis. At these conditions, the RC presented the lowest values of TSS and total phosphorus (100 mg L−1 and 7.0 mg P L−1, respectively), and the following other characteristics: 1,001 mg Al L−1; 384 mg Fe L−1; 1100 mg COD L−1.
Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?
Authors: Bjørklund Geir , Storchylo Olha , Peana Massimiliano , Hangan Tony , Lysiuk Roman , Lenchyk Larysa , Koshovyi Oleh , Antonyak Halyna , Hudz Nataliia , Chirumbolo Salvatore 
Published: November 2023

Background:
Propolis and its major phenolic compound, caffeic acid
phenethyl ester (CAPE), have garnered considerable scientific interest due to their anti-
inflammatory properties and potential therapeutic applications.

Objectives:
This narrative review explores the potential utility of CAPE in cancer treatment.

Methods:
We comprehensively reviewed relevant studies from scientific databases
(PubMed and Web of Science) from 2000 to 2022. Our search focused on keywords
such as cancer, natural drugs, caffeic acid phenethyl ester, CAPE, cancer cell lines, antitumor
effects, and propolis.

Results:
CAPE exhibits diverse biological benefits, including antimicrobial, antioxidant,
antiviral, anti-inflammatory, cytotoxic, and potentially anti-carcinogenic properties. Numerous
studies have demonstrated its wide-ranging antitumor effects on various cancer
cell lines, including growth inhibition, apoptosis induction, tumor invasiveness prevention,
malignancy suppression, and anti-angiogenic activity.

Conclusion:
Following comprehensive preclinical toxicity assessments, further evaluation
of CAPE's efficacy and safety through clinical trials is highly recommended to elucidate
its potential health benefits in diverse forms of human cancer.
Enterococcal Infections: A Comparative Analysis between the Pandemic
and the Pre-pandemic Period
Authors: Sharad Neha , Srivastava Smriti , Kiro Vandana Vijayeta , Varma Sharin , Srivastav Sharad , Ningombam Aparna , Malhotra Rajesh , Mathur Purva 
Published: November 2023

Introduction:
During the COVID-19 pandemic, higher Enterococcus bloodstream infections (BSI) rates have been reported. To establish whether these infections actually increased, we
compared the incidence of Enterococcal infections before (September 2019 to February 2020) and
during the pandemic (April 2020 to March 2022).

Materials and Methods:
This retrospective observational study was conducted at a tertiary care center converted into a COVID-19 facility. All clinical samples received in our laboratory during the
study period were included.

Results:
In the six months preceding the pandemic, 2,243 samples were positive for bacterial growth;
of the isolated organisms, 100 were Enterococcus species. During the pandemic, 39 out of 996 positive samples were Enterococcus. E. faecium was the most common isolate, 79/99 and 37/39. BSI was
the most common overall infection (554/996; 55.6%) compared to the period before it (287/2243;
12.79%). Enterococcus species accounted for 30 out of 554 (5.41%) BSI in COVID-19 patients and
21/287 in the period before it (7.31%). Ten out of 39 (25.64%) isolates were vancomycin-resistant
compared to the pre-COVID-19 period (9/21; 42.8%). There was an increase in antimicrobial resistance in the pandemic, except for linezolid and high-level aminoglycoside.

Conclusion:
Although we noted a higher percentage of BSIs, Enterococci were isolated from a lesser rate of COVID-19 patients from our center compared to pre-pandemic times. The plausible reasons for this could be the protective gut microbiota in the Indian population, and no increase in Enterococcus species in the environment of patients.
Retrospectiva de los actos emanados del ex tribunal supremo electoral en materia electoral
Authors: Guerra Troya Leonardo , Barrera Andaluz Diego 
Published: November 2023

El presente artículo tiene la finalidad de conocer las competencias y funciones constitucional y legalmente otorgadas al antiguo Tribunal Supremo Electoral del Ecuador, esto, con el objeto de adentrarnos en un próximo análisis histórico de la Función Electoral en nuestro país a partir de la vigencia de la Constitución de la República del Ecuador del 2008, para lo cual resulta necesario el desarrollo de este trabajo como un antecedente, para entender de mejor manera la evolución histórica de estructura actual de la Función Electoral.
Improving the Social Utility Evaluation of Brazilian Community Banks: A Study on Banco dos Cocais
Authors: Leal Mariane Goretti de Sá Bezerra , Silva Júnior Jeová Torres 
Published: November 2023

Purpose: The aim of this article is to improve the model for evaluating the social utility of Brazilian Community Development Banks (CDB), based on the perceptions of managers and users-clients-beneficiaries.

Theoretical Framework: The CDBs are solidarity finance initiatives, inserted in the social and solidarity economy in Brazil, whose purposes are carried out based on their social utility in terms of the results achieved with their model of action for the human, political, economic and social development of the territories.

Method: This is an exploratory and descriptive research using a qualitative approach. Data was collected through a documentary survey, field observation and semi-structured interviews at the CDB Banco dos Cocais dos based on the categories of social utility (socio-environmental, socio-political, socio-cultural, socio-economic and socio-institutional). The data was analyzed using content analysis..

Results and Conclusions: Of the 35 subcategories of social utility analyzed, 29 were covered by CDB Banco dos Cocais. The socio-economic, socio-cultural, socio-institutional and socio-environmental categories showed the greatest impact on the social utility of Banco dos Cocais, while the socio-political category showed the least impact, signaling the need to strengthen the political empowerment of the population in the territory.

Research Implications: This research's theoretical contribution includes the reconfiguration of the DECID matrix for social utility evaluation. From the perspective of practical implications, the study aims to contribute to improving the management and evaluation of the CDBs' actions in their territories.

Originality/Value: The research seeks to show that the actions of the CDBs have a strong social utility integrated into the development and strengthening of the territories, which is greater than their solely economic results.
Optimizing the Strategic Communication of Gerbas Tani Community in Developing Tourist Village in Kedungrejo, Rowokangkung, Lumajang
Authors: Fahma Alhimni , Arifulin Nuha Achmad 
Published: November 2023

Gerbas Tani stands for Gerakan Belanja Sayur dari Lahan Petani, which was born in 2018, marked by the educational activity "Petik Tomat" for kindergarten students. The mascot of Gerbas Tani is a 0.1-hectare flower garden in the middle of a 2.5-hectare vegetable garden. The total number of visitors when the flower garden is in bloom reaches 20,000 people, with an average of 30-50 visitors per day. However, due to the pandemic, vegetable sales have stopped, and tour visitors are limited. The mentoring process was carried out through the Asset Based Community Development (ABCD) approach through the stages of discovery, dream, design, define, and destiny to optimize strategic communication to develop the potential of Gerbas Tourism Village.
The results of this service have successfully encouraged the Gerbas Tani Community to become a solid community to preserve the tourist village through persuasive communication. Gerbas Tani members become actors of change collectively in order to realize a sustainable and developing village through the development of online sales while maintaining offline sales. They consistently hold different tourism activities three times a year as a solution to developing a tourist village after the Pandemic.
The findings highlight the importance of strategic communication in empowering local communities, strengthening partnerships, and promoting sustainable economic development in the context of tourism villages.
El Vacío. Reflexiones en torno a su experiencia y posible relación con el campo del diseño arquitectónico
Authors: Torero Mercedes Viviana 
Published: November 2023

El interés por el vacío surge del misterio y de la variedad de acepciones con las que se usa el término dentro del campo de la arquitectura, tanto en el ámbito académico como en la práctica profesional.
Este artículo tiene como objetivo analizar la compleja noción de vacío y su interacción tanto en el ámbito intelectual como en la práctica arquitectónica. Este análisis se realiza a través de diversas disciplinas como la filosofía, sociología, el arte, la psicología, la arquitectura, entre otros. De esa manera, se intenta contar con un panorama amplio y comprender la presencia e influencia de los diversos significados del término dentro del campo de diseño arquitectónico. Todo esto con el fin de obtener una aproximación a su entendimiento y su relevancia en la experiencia del ser humano.
Se explora la relación “sujeto – objeto”, es decir, las diversas formas en que los seres humanos experimentan el vacío y cómo se produce este encuentro. Todo esto con el fin de obtener una perspectiva general del término vacío y comprender cómo se da esta experiencia. Finalmente, se dirige la mirada a lo puntual, explorando la relación del vacío en los procesos que ocurren dentro del campo del Diseño Arquitectónico destacando la importancia de considerar los aspectos socioculturales y perceptivos.
IMPLEMENTASI SUPERVISI AKADEMIK DALAM PENGEMBANGAN PROFESI GURU OLEH KEPALA SEKOLAH MENENGAH ATAS (SMA) BLOKAGUNG TEGALSARI BANYUWANGI
Authors: Khaudli M Imam , Sari Elfa Naily 
Published: November 2023

Academic supervision is a series of activities to help teachers develop their ability to manage the learning process to achieve learning objectives. The principal is one of the keys to the success of a quality educational institution in both process and output, therefore the principal as a supervisor is expected to motivate, foster, and develop teacher competence for the development of the teaching profession. The quality of education that runs effectively and efficiently is related to the principal's leadership with how the principal can influence teachers and school employees to achieve the vision, mission, and school goals that have been previously planned in developing the teaching profession at SMA Blokagung Tegalsari Banyuwangi. This study reveals the implementation of academic supervision in the development of the teaching profession at SMA Blokagung Tegalsari Banyuwangi, with the research focus: 1) planning for academic supervision carried out by the head of SMA Blokagung Tegalsari Banyuwangi 2) implementation of academic supervision by the head of SMA Blokagung Tegalsari Banyuwangi 3) the impact of academic supervision in professional development by the principal of SMA Blokagung Tegalsari Banyuwangi. This study uses a qualitative approach. The methods used in data collection include 1) interviews/ interviews 2) observation 3) documentation. These three methods are used to obtain research findings, these are analyzed by data reduction, data presentation, and data verification and drawing conclusions. The triangulation used includes several components: 1) Triangulation with theory; 2) Triangulation by method; 3) Triangulation with investigators. The results showed that: 1) Planning for the academic supervision of the principal at SMA Blokagung Tegalsari Banyuwangi based on increasing competence and the teaching profession is an activity that is carried out every semester change by involving all waka and senior teachers. 2) the implementation of individual academic supervision includes class visits, observations, individual meetings, and self-assessment. Followed up with group techniques include holding meetings, holding group discussions, and conducting upgrading. 3) academic supervision has a real impact on the professional development of teachers at SMA Blokagung Tegalsari Banyuwangi so that teachers can find out shortcomings when teaching and teachers know things that need to be addressed and improve the quality of learning in the classroom