bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Reporting System of Chemical Poisoning and Drug Safety Program in the Governmental and Private Hospitals in Jeddah City, Saudi Arabia, A Cross-Sectional Study
Authors: Kareem Mohammed Abdulaziz , Alzahrani Khalid Mohammed , Alshehri Amjed Said , Almasri Nedal Jamal A. , Almutairi Wael Abdi , Alghamdi Adel Saed 
Published: December 2023

Background: Chemical poisoning is a major health issue. This study aimed to assess and evaluate the reporting system of chemical poisoning and drug safety program (CSP) in the governmental and private hospitals in Jeddah city, Saudi Arabia.
Methods: This descriptive and analytical cross-sectional study was conducted in Jeddah city, Saudi Arabia in the period from January to June 2022. we included 30 governmental and private hospitals that included more than 150 beds. To collect data, this study used a 17-item evaluation form that was approved and used by the Saudi Ministry of Health to evaluate the reporting systems in the hospitals in the country.
Results: Regarding the Reporting system in the public health departments (PHD), the Ministry of Health (MOH) memo for reporting cases of chemical and drug overdose is present in 80% of the hospitals, 30% reported that samples sent to the toxicology center are received. Regarding the Reporting system in the emergency department, 46.7% reported that death cases are immediately reported to the PHD. Regarding the Reporting system in hospital laboratory, 46.5% reported that chemical and drug overdose samples are sent to the Toxicology Center. Reporting system in the public health department and Reporting system in the emergency department were better in the Private hospitals (p =0.042 and p=0.045, respectively).
Conclusion: Low adherence was found in the recruited hospitals. Less adherence was found in the governmental hospitals, particularly in the reporting system in the public health departments and the reporting system in the emergency departments. Some hospitals scored low in the three domains of the evaluation form.
Ru Quantum Dots Modified Mucor‐Derived Carbon Submicroribbons for Advanced Lithium‐Sulfur Batteries
Authors: Liang Sheng , Feng Gaojian , Ding Xinkai , Hu Kunhong , Liang Xin , Zhou Ningning , Hu Lei , Liu Lingli , Wang Lili , Pan Hongge , Chen Bin , Liang Chu 
Published: January 2025

AbstractThe natural structure of the bio‐templates with high fidelity can provide a novel pathway to synthesize carbon materials with unique microstructure and morphology for high‐performance energy storage. Herein, a novel and facile strategy is proposed to synthesize nitrogen and phosphorus co‐doped carbon submicroribbons with 3D cross‐linked network structure (CSR) derived from mucor hyphae and their derivatives. The size of mucor hyphae can be customized by tunning the kitchen‐type cultivation process of mucor grown on tofu surfaces. The derivative of Ru quantum dots modified porous CSR (Ru@PCSR) is successfully synthesized by combining pore‐forming with introducing Ru quantum dots. Ru@PCSR exhibits a large specific surface area, high electronic and ionic conductivity, superior lithium polysulfides (LiPSs) adsorption, and high catalytic activation toward LiPSs conversion. The Ru@PCSR is designed to introduce into Li2S cathode and polypropylene (PP) separator as multifunctional frameworks to form a new Ru@PCSR‐Li2S || Ru@PCSR/PP || Li metal battery, exhibiting a high discharge capacity of 960 mAh g−1 at 0.5 A g−1, superior rate performance and excellent cycling stability over 750 cycles. This study provides a new avenue for the preparation of carbon materials with unique microstructure and morphology for advanced energy storage by means of the natural structure in bio‐precursors.
Dual‐Action Antibacterial Nanoblades for Rapid Inactivation of Bioaerosols in Personal Protective Equipment
Authors: Park Se Kye , Lee Seung Yeon , Kim Sang Bok , Kim In Ho , Lee Dong Uk , Shin Jae Hak , Son Jeong Sang , Kim Gunwoo , Yoo Seung Hwa , Lee Dong Yun , Jung Jae Hee , Choi Dong Yun 
Published: January 2025

AbstractCommercial personal protective equipment (PPE) often has limited antibacterial activity that compromises its effectiveness in preventing infections. Traditional mechano‐bactericidal methods deliver suboptimal performance, while photo‐bactericidal methods struggle with activation requirements and durability. In this study, a dual‐action antibacterial PPE, combining mechano‐ and photo‐bactericidal strategies, have been designed to overcome these challenges. Mg–Al layered double hydroxide nanoblades (LDH‐NBs) are synthesized on polydimethylsiloxane (PDMS)‐coated polypropylene (PP) fabric. The PDMS coating plays a crucial role in enabling the formation of densely packed LDH‐NBs, thereby implementing mechano‐bactericidal action. Additionally, hydrophobic residues in the PDMS coating diffuse to the surface during heat treatment, converting the LDH‐NB surface to hydrophobic. The Rose Bengal (RB)‐adsorbed LDH‐NBs (RB@LDH‐NBs) become superhydrophobic after heat treatment, thereby exhibiting antifouling effects against various contaminants and bacteria. RB@LDH‐NBs mechanically inactivate 99.5% of Escherichia coli and 95% of Staphylococcus aureus under typical respiratory flow rates and completely eradicate E. coli within 2 h of light exposure. Combining mechano‐ and photobactericidal effects, RB@LDH‐NBs rapidly eradicate both E. coli and S. aureus within 15 min of light exposure. These outstanding bactericidal performances highlight the potential of this advanced PPE to provide robust protection against infectious diseases.
Bioprinted Micro‐Clots for Kinetic Analysis of Endothelial Cell‐Mediated Fibrinolysis
Authors: Chang Jonathan J. , Brew Kelsey , Hamilton Jamie A.G. , Kumar Varun , Diaz José A. , Takayama Shuichi 
Published: January 2025

AbstractVascular hypo‐fibrinolysis is a historically underappreciated and understudied aspect of venous thromboembolism (VTE). This paper describes the development of a micro‐clot dissolution assay for quantifying the fibrinolytic capacity of endothelial cells – a key driver of VTE development. This assay is enabled using aqueous two‐phase systems (ATPS) to bioprint microscale fibrin clots over human umbilical vein endothelial cells (HUVECs). Importantly, these micro‐clots are orders of magnitude smaller than conventional fibrin constructs and allow HUVEC‐produced plasminogen activators to mediate visually quantifiable fibrinolysis. Using live‐cell time‐lapse imaging, micro‐clot dissolution by HUVECs is tracked, and fibrinolysis kinetics are quantified. The sensitivity of cell‐driven fibrinolysis to various stimuli is rapidly tested. The physiological relevance of this convenient high‐throughput assay is illustrated through treatments with lipopolysaccharide (LPS) and rosuvastatin that elicit anti‐ and pro‐fibrinolytic responses, respectively. Furthermore, treatment with baricitinib, an anti‐inflammatory therapeutic found to increase cardiovascular risks after market approval, provokes an anti‐fibrinolytic response – which highlights the potential role of endothelial cells in increasing VTE risk for patients receiving this drug. This endothelial cell fibrinolysis assay provides a high‐throughput and versatile drug testing platform – potentially allowing for early preclinical identification of therapeutics that may beneficially enhance or adversely impair endothelial fibrinolysis.
A Dual‐Pipeline Lactate Removal Strategy to Reverse Vascular Hyperpermeability for the Management of Lipopolysaccharide‐Induced Sepsis
Authors: Ge Shuangfeng , Wang Xing‐Huo , Fan Juntao , Liu Haofei , Xin Youtao , Li Xiaohui , Yu Yunjian , Yang Ying‐Wei , Gao Hui 
Published: January 2025

AbstractSepsis is an underappreciated yet severe threat to human life, marked by organ dysfunction and high mortality resulting from disordered inflammatory responses to blood infection. Unfortunately, no specific drugs are available for effective sepsis treatment. As a pivotal biomarker for sepsis, lactate levels are closely related to vascular permeability and sepsis‐associated mortality. Herein, a dual‐pipeline lactate removal strategy is reported from circulating blood to ameliorate vascular permeability and lipopolysaccharide (LPS)‐induced sepsis. This is achieved by formulating lactate oxidase (LOX)‐encapsulated hollow manganese dioxide (HMnO2) nanohybrids (LOX@HMnO2‐P[5]A) bearing pillar[5]arene (P[5]A) macrocycle with excellent host‐guest properties. The highly biocompatible nanohybrids enable direct lactate consumption through LOX catalytic degradation and block lactate production by P[5]A‐mediated LPS trapping, allowing for dual‐pipeline lactate removal to maximize the reversal of lactate‐mediated vascular hyperpermeability. Besides, HMnO2 cores decompose hydrogen peroxide produced from lactate oxidation into oxygen, further contributing to lactate consumption and mitigating the hypoxic inflammatory environment. In vivo investigations demonstrate that intravenous administration of LOX@HMnO2‐P[5]A nanohybrids with extended blood circulation can effectively ameliorate endothelial barrier dysfunction, inflammatory responses, and multiple organ injury, ultimately improving survival outcomes in LPS‐induced sepsis. Taken together, this dual‐pipeline lactate removal strategy offers a promising approach for efficient sepsis treatment.
Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss
Authors: Fischer Eliana O. , Tsukerman Anna , Machour Majd , Shuhmaher Margarita , Silverstein Asaf , Yaakov Maya , Bar‐Am Orit , Debbi Lior , Levenberg Shulamit 
Published: January 2025

AbstractVolumetric muscle loss (VML) refers to muscle tissue loss exceeding 20% within a functional area due to trauma or surgery, often leading to physical disabilities. VML treatment relies on the transplantation of autologous flaps harvested from a healthy‐donor site while minimizing the probability of immune rejection. However, this approach often leads to donor‐site morbidity and relies on a restricted supply of muscle tissue. Current solutions in tissue engineering focus on engineered grafts lacking hierarchical vasculature with a feeding vessel, thus limited by diffusion. This study expanded upon a new approach of multimodal bioprinting which enabled the fabrication of thick hierarchical vascular muscle flaps composed of bioprinted and vascularized skeletal muscle tissue, and a 3D‐printed engineered macrovessel, which successfully repaired VML injury in‐vivo. The flaps are implanted by anastomosing the macrovessel via microsurgery to the femoral artery in proximity to an induced VML injury in Sprague‐Dawley rat hindlimbs. Immediate perfusion of the flaps is demonstrated, as is flap endurance to physiological blood pressure, flow, and shear stress. Flap implantation enhanced myocyte differentiation, and vascular ingrowth and facilitated tissue viability and integration. These results obtained by utilizing human‐origin cells provide a foundation for fabricating patient‐specific flaps for the treatment of extensive soft tissue defects.
Chiral Amplifier With Highly Tunable Plasmonic Optical Activities for Molecular Chirality Sensing
Authors: Ma Xiaoyun , Liu Shengli , Ji Yinglu , Ma Sijia , Jiang Jian , Zhang Li , Wu Xiaochun , Li Jiafang , Liu Minghua , Wang Rong‐Yao 
Published: January 2025

AbstractThe transfer of chirality from molecules to plasmons is capable of amplifying chiroptical information. Here, a molecular‐to‐plasmonic chirality transfer system that uses two different molecular chirality inputs to produce a plasmonic chirality output is reported. This system functions as a transistor‐analogous chiral amplifier, where the flow of chiral information from the source (helical fibrils) to the drain (a chiral assembly of gold nanorods) is regulated by molecular chirality recognition between the source and the gate (amino acids). More importantly, a high degree of control over the molecular‐to‐plasmonic chirality transfer is evidenced not only by a quantitative correlation between the molecular chirality input at the gate and the plasmonic chirality output at the drain, but also by the ability of asymmetrical perturbations induced by source‐gate chirality recognition to generate substantial variations in the chiroptical amplification of the plasmonic drain output, ranging from 1.22% to 314.93%. Furthermore, this transistor‐analogous chiral amplifier can be used to precisely analyze the concentration and chiral purity of gate molecules. This findings have the potential to advance the design of asymmetric functional nanodevices, with implications for chiral information processing and biosensing applications.
CD47 Knock‐Out Using CRISPR‐Cas9 RNA Lipid Nanocarriers Results in Reduced Mesenchymal Glioblastoma Growth In Vivo
Authors: Rouatbi Nadia , Walters Adam A. , Zam Alaa , Lim Yau Mun , Marrocu Alessia , Liam‐Or Revadee , Anstee Joanne E. , Arnold James N. , Wang Julie Tzu‐Wen , Pollard Steven M. , Al‐Jamal Khuloud T. 
Published: January 2025

AbstractImmune checkpoint (ICP) blockade has shown limited effectiveness in glioblastoma (GBM), particularly in the mesenchymal subtype, where interactions between immune cells and glioblastoma cancer stem cells (GSCs) drive immunosuppression and therapy resistance. Tailoring ICPs specific to GSCs can enhance the antitumor immune response. This study proposes the use of lipid nanoparticles (LNPs) encapsulating CRISPR RNAs as an in vivo screening tool for ICPs in a syngeneic model of mesenchymal GSCs. Using PD‐L1 and CD47 to validate the proof of concept, intratumoral administration of LNPs in orthotopic tumors achieved efficient editing of ICPs, leading to enhanced immune cell infiltration within the tumor microenvironment. Targeting CD47 reduced tumor growth, suggesting improved cancer cell sensitization to the immune system post‐ICP editing. The study positions LNPs as a robust tool for in vivo validation of ICPs as therapeutic targets in clinically relevant GBM models. LNPs could serve as a screening tool in patient‐derived xenografts to identify and optimize ICP combinations, potentially expediting ICP translation and enhancing personalized GBM immunotherapies.
Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models
Authors: Cai Zhixiong , Li Zhenli , Zhong Wenting , Lin Fangzhou , Dong Xiuqing , Ye Honghao , Guo Yutong , Chen Geng , Yu Xiaoling , Yu Haijun , Tang Ruijing , Liu Xiaolong 
Published: January 2025

AbstractThe immunosuppressive microenvironment in pancreatic cancer, characterized by low tumor‐specific T cells and excessive fibrosis, limits the effectiveness of immunotherapy. Here, three datasets and multi‐immunofluorescence staining of tissue microarrays in pancreatic cancer indicate that mesothelin (MSLN) expression negatively correlates with cytotoxic T cells in tumor. Anti‐MSLN antibody (αMSLN) treatment of pancreatic cancer in vivo can significantly increase T cell infiltration. Meanwhile, the combination of αMSLN and neoantigen peptide vaccine identified from pancreatic cancer cell lines is demonstrated to be more effective in inducing neoantigen‐specific T cell generation and infiltration at subcutaneous and orthotopic pancreatic cancer models for enhancing antitumor efficacy. Single‐cell transcriptome analysis shows that the combined treatment significantly reduces the proportion of fibroblasts, improves the infiltration of IFN‐γ+CD4+ and GZMK+CD8+ T cells, as well as reduces the interaction of antigen presentation‐associated ligands and receptors between antigen‐presenting Cancer‐Associated Fibroblasts (apCAFs) and naive CD4+ T cells. The negative correlations between apCAFs and CD8+ T cells/IFN‐γ+CD4+ T cells are further confirmed in human pancreatic cancer tissues. Overall, this study demonstrates that targeting MSLN can improve neoantigen vaccine induced immune efficacy by reducing apCAFs to interrupt the conversion of naive CD4+ T cells to Tregs, and therefore increase the infiltration of tumor‐specific T cells.
Unveiling the Li/Electrolyte Interface Behavior for Dendrite‐Free All‐Solid‐State Lithium Metal Batteries by Operando Nano‐Focus WAXS
Authors: Liang Yuxin , Apfelbeck Fabian A.C. , Sun Kun , Yan Yingying , Cheng Lyuyang , Pan Guangjiu , Zheng Tianle , Cheng Yajun , Davydok Anton , Krywka Christina , Müller‐Buschbaum Peter 
Published: January 2025

AbstractPoly(ethylene oxide) (PEO)‐based solid composite electrolytes suffer from poor conductivity and lithium dendrite growth, especially toward the metallic lithium metal anode. In this study, succinonitrile (SN) is incorporated into a PEO composite electrolyte to fabricate an electrode‐compatible electrolyte with good electrochemical performance. The SN‐doped electrolyte successfully inhibits the lithium dendrite growth and facilitates the SEI layer formation, as determined by the operando nanofocus wide‐angle X‐ray scattering (nWAXS), meanwhile, stably cycled over 500 h in Li/SN‐PEO/Li cell. Apart from the observation of lithium dendrite, the robust SEI layer formation mechanism in the first cycle is investigated in the SN‐enhanced composite electrolyte by nWAXS. The inorganic electrochemical reaction products, LiF and Li3N, are found to initially deposit on the electrolyte side, progressively extending toward the lithium metal anode. This growth process effectively protected the metallic lithium, inhibited electron transfer, and facilitated Li⁺ transport. The study not only demonstrates a high‐performance interfacial‐stable lithium metal battery with composite electrolyte but also introduces a novel strategy for real‐time visualizing dendrite formation and SEI growth directing at the interface area of electrolyte and metallic lithium.
Exploration of Multidimensional Structural Optimization and Regulation Mechanisms: Catalysts and Reaction Environments in Electrochemical Ammonia Synthesis
Authors: Chu Kaibin , Weng Bo , Lu Zhaorui , Ding Yang , Zhang Wei , Tan Rui , Zheng Yu‐Ming , Han Ning 
Published: January 2025

AbstractAmmonia (NH3) is esteemed for its attributes as a carbon‐neutral fuel and hydrogen storage material, due to its high energy density, abundant hydrogen content, and notably higher liquefaction temperature in comparison to hydrogen gas. The primary method for the synthetic generation of NH3 is the Haber–Bosch process, involving rigorous conditions and resulting in significant global energy consumption and carbon dioxide emissions. To tackle energy and environmental challenges, the exploration of innovative green and sustainable technologies for NH3 synthesis is imperative. Rapid advances in electrochemical technology have created fresh prospects for researchers in the realm of environmentally friendly NH3 synthesis. Nevertheless, the intricate intermediate products and sluggish kinetics in the reactions impede the progress of green electrochemical NH3 synthesis (EAS) technologies. To improve the activity and selectivity of the EAS, which encompasses the electrocatalytic reduction of nitrogen gas, nitrate, and nitric oxide, numerous electrocatalysts and design strategies have been meticulously investigated. Here, this review primarily delves into recent progress and obstacles in EAS pathways, examining methods to boost the yield rate and current efficiency of NH3 synthesis via multidimensional structural optimization, while also exploring the challenges and outlook for EAS.
High‐Frequency Inductors by Co‐Design Optimization of Self‐Rolled‐up Membrane Technology
Authors: Nguyen Kristen Minh‐Thu , Yang Zhendong , Wang Allen Tsingyuan , Wicker Scott Ambros , Li Xiuling 
Published: January 2025

AbstractSelf‐rolled‐up membrane (S‐RuM) 3D microtube inductors represent a significant advancement in miniaturization for radio frequency (RF) integrated circuit applications, particularly internet‐of‐things and 5G/6G communications. These inductors have excellent high‐frequency performance due to better confinement of the magnetic field and weak dependence on substrate conductivity. However, previously reported S‐RuM inductor frequencies are limited by the crosstalk capacitance between overlapping metal strips between rolled‐up turns. This work advances S‐RuM inductor design by co‐optimizing inductance, frequency, and footprint, leading to significant reductions in crosstalk capacitance and enhancements in maximum operating frequencies. Design intricacies tailored to the unique structure of S‐RuM inductors are thoroughly addressed, particularly by mapping the angle of the rolled‐up inductor strips with respect to the number of turns. Self‐resonance frequencies as high as 40–53 GHz (instrument testing limit) are reported for 2–5 rolled‐up turns, demonstrating increases of over 15 GHz from previous S‐RuM inductors. These designs, with footprints of 0.02–0.56 mm2 and inductances of <1 nH to >5 nH at GHz frequencies, demonstrated the effectiveness of co‐designing frequency, footprint, and inductance for RF inductors, openning a new paradigm for miniaturizing high‐frequency on‐chip passive electronic components.
Paddy rice traits estimation under varying management strategies using UAV technology
Authors: Muhindo Daniel , Lelei Joyce J. , Munyahali Wivine , Cizungu Landry , Doetterl Sebastian , Wilken Florian , Bagula Espoir , Okole Nathan , Rewald Boris , Mwonga Samuel 
Published: January 2025

AbstractTimely crop monitoring and yield prediction are essential in guiding management decision making. The aim of the study was to estimate the agronomic traits of paddy rice (Oryza sativa L.) using unmanned aerial vehicle (UAV)‐multispectral imaging. A randomized complete block design field experiment with a split–split plot arrangement was set up in the Ruzizi plain, Democratic Republic of Congo (DRC). Spectral imaging data were collected at rice tillering and panicle initiation stages. Predictive analysis of rice agronomic traits was performed using linear and decision tree‐based machine learning techniques. Paddy rice trait predictions were critically sensitive to the timing of image acquisition but not largely affected by the model. The most accurate predictions were made at rice panicle initiation stage, with R2 values of 0.62, 0.65, and 0.75 for yield, aboveground biomass, and plant nitrogen (N) uptake, respectively. The visible atmospherically resistant index (VARI), modified chlorophyll absorption in reflective index, and ratio vegetation index, along with near infrared and green bands, played a critical role in predicting paddy rice N uptake and yield. The same spectral features associated with crop height and canopy data were essential for predicting paddy rice aboveground biomass. UAV‐multispectral data were able to assess agricultural intensification strategies at field/landscape scale irrespective of soil types, watering regimes, and cultivars. Special consideration should be attributed to VARI, as it enables economical prediction of paddy rice traits. The UAV technologies are therefore reliable tools for monitoring rice production and can be applied in agricultural extension in the DRC.