bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postprandial facial rash in an infant
Authors: Hofmeister Nicole , Ames Michael , Lee Amanda 
Published: February 2024

ABSTRACT
This article describes an infant who developed a facial rash within minutes of eating certain foods. The rash resolved within 30 minutes. The patient was diagnosed with auriculotemporal syndrome or Frey syndrome, which is characterized by sweating or flushing in the preauricular area when the patient consumes certain foods, especially those that are acidic, sour, or spicy. Because most patients outgrow the syndrome, no treatment is needed.
CE: Beyond PICO—A New Question Simplifies the Search for Evidence
Authors: Waldrop Julee , Dunlap Jayne Jennings 
Published: February 2024

ABSTRACT
The framework for the PICO (population, intervention, comparison intervention, outcome) question was developed for use in the field of medicine to help determine the best treatment or intervention for a patient. However, use of the PICO question often fails to make sense when the problem or issue of interest is unrelated to determining the best treatment; in such cases, PICO is a less-than-optimal framework to use in searching for evidence. Nurses undertaking an evidence-based practice quality improvement (EBPQI) initiative must begin with a full understanding of the problem by exploring both external evidence (research) and internal evidence from the local setting to support the initiative. This article presents the framework for an alternative question—PPCO, or problem, population, change, outcome—that simplifies the search for evidence and provides a universal approach to question development for EBPQI initiatives. The PPCO question was developed for use with all nursing issues that need addressing.
Palliating Serious Illness During Disasters and Public Health Emergencies
Authors: Mayahara Masako , Tay Djin L. , Kates Jeannette , Rosa William E. 
Published: February 2024

ABSTRACT:
The increase in disasters and public health emergencies in recent years is a serious public health concern. The needs of suffering victims can be multifaceted, particularly the needs of those who are from systematically marginalized populations. Palliative care nurses play a vital role in mitigating the suffering of those affected by these events. Despite the acute need, there is a lack of nurses who specialize in hospice and palliative care and generalist nurses are not sufficiently prepared to provide palliative care during disasters and public health emergencies. Nurses and nursing students should use national and global resources and training opportunities to hone their palliative care skills as well as learn self-care skills to increase their resiliency. Outcomes from research and collaborative efforts should be used to educate the future nursing workforce and advocate for equitable delivery of quality palliative care for all people who are affected by disasters and public health emergencies.
Gender-affirming care for the adolescent patient
Authors: Pomarico-Denino Vanessa 
Published: February 2024

Abstract:
Over the past decade, the number of children and adolescents who identify as transgender and/or gender diverse has increased. It is essential for clinicians to have the knowledge and resources to effectively care for these patients, identify associated risks (such as sexually transmitted infections, unplanned pregnancy, depression, anxiety, and increased suicide risk) as well as to understand hormone therapy to help patients achieve desired expression of the gender with which they identify.
Reexamining the complex issue of obesity in childhood
Authors: Shreve Marilou D. , Scott Allison , Davis Renée L. 
Published: February 2024

Abstract:
Obesity in childhood is a complex, multifaceted condition with various contributors, including genetic, environmental, socioeconomic, and physiologic factors. The latest guidelines recommend annual evaluation beginning at age 2 years. Treatment strategies should be family focused and should target nutrition, physical activity, and behavior.
The evidence-based COPE program
Authors: Melnyk Bernadette Mazurek 
Published: February 2024

Abstract:
The soaring prevalence of depression and anxiety in children, teenagers, and young adults is now a public health epidemic, yet access to timely evidence-based mental health treatment is often lacking due to a severe shortage of mental health providers. This article provides an overview of the current state of depression and anxiety in children and adolescents as well as first-line evidence-based treatment. The Creating Opportunities for Personal Empowerment (COPE) program, a cognitive-behavioral skills-building intervention, is highlighted as an evidence-based intervention for timely treatment that can be delivered by NPs, physicians, and physician associates/assistants in primary care settings, school-based health centers, and chronic care clinics with reimbursement as well as in schools and universities as a preventive mental health intervention.
Sleep quality and the intention to modify sleep behaviors among night-shift nurses
Authors: Durkin Adelaide Caroci , Richards Andrew John 
Published: February 2024

Purpose:
To explore the relationship between sleep quality and intent to change sleep behaviors among night-shift nurses.

Methods:
Full-time night-shift nurses in a hospital setting completed a cross-sectional online survey including demographics, Snoring, Tiredness during daytime, Observed apnea, and High Blood Pressure (STOP) Questionnaire, the Pittsburgh Sleep Quality Index (PSQI), and the Intention to Change Behavior Scale (ICBS). The relationship between PSQI and ICBS scores was tested using Spearman's rho correlation coefficient.

Results:
Most participants reported poor sleep and did not engage in health behaviors that promote good sleep. There was a weak, positive relationship between PSQI and ICBS scores. Those who reported poor sleep quality indicated a high intent to improve sleep.

Conclusion:
These findings support the need for night-shift nurses to prioritize enhancing their sleep quality by advocating for policy and practice improvements. The findings also highlight the importance of support from nurse leaders, educators, and researchers to raise awareness and implement holistic strategies for better sleep health.
Debridement options for the interprofessional team
Authors: Rajhathy Erin M. , Hill Mary C. , Tran David L. , Huang Ren-Wen , Chiu Ernest S. , Sibbald R. Gary , Ayello Elizabeth A. 
Published: February 2024

Abstract:
Debridement is a core component of chronic wound management. Although various debridement methods exist, each carries a unique patient risk level. This article discusses the different normal tissue components that are critical to safe debridement practice, various methods of wound debridement for nurses, and the importance of an interprofessional team and consulting a wound specialist.
Every drop counts
Authors: Stucky Christopher H. , Stucky Michelle G. , Dindinger Rebeccah A. 
Published: February 2024

Abstract:
Over half of surgeries in the US are conducted in physician-owned ambulatory surgery centers (ASCs). While ASCs provide cost-effective and quality healthcare comparable to inpatient hospitals, they often lack robust support services, including lactation support. This article presents key information on breastfeeding benefits, early weaning risks, and strategies for nurses in ASCs to educate and support patients who are breastfeeding.
Planned Delivery or Expectant Management for Late Preterm Pre-eclampsia in Low-Income and Middle-Income Countries (CRADLE-4): A Multicentre, Open-Label, Randomized Controlled Trial
Authors: Beardmore-Gray Alice , Vousden Nicola , Seed Paul T. , Vwalika Bellington , Chinkoyo Sebastian , Sichone Victor , Kawimbe Alexander B. , Charantimath Umesh , Katageri Geetanjali , Bellad Mrutyunjaya B. , Lokare Laxmikant , Donimath Kasturi , Bidri Shailaja , Goudar Shivaprasad , Sandall Jane , Chappell Lucy C. , Shennan Andrew H. 
Published: February 2024

(Abstracted from Lancet 2023; 402:386–396)
Preeclampsia is a disorder of pregnancy that proposes a disproportionately high risk to women in low- and middle-income countries (LMICs); it is one of the leading causes of maternal morbidity and mortality worldwide and is estimated to have an annual death toll of greater than 40,000. The only treatment with proven effectiveness for preeclampsia is delivery, but there are risks to both mother and infant associated with preterm delivery that contribute to both of their short- and long-term outcomes.
Global burden of pediatric asthma and rhinitis – what we have recently learned from epidemiology
Authors: Romero-Tapia Sergio de Jesús , García-Marcos Luis 
Published: February 2024

Purpose of review
To analyze and present recently published information on the factors that modify the burden of asthma and rhinitis in pediatric ages, such as ecological determinants; highlighting access and adherence to medications, exposure to pollutants and climate change. In addition to individual determinants such as obesity, protective & risk factors and comorbidities.

Recent findings
Asthma and rhinitis continue to have a significant impact worldwide on the health of affected patients, primarily children. The burden of asthma is greatest in developing countries and vulnerable populations, resulting in increased morbidity, potentially preventable asthma deaths and socioeconomic consequences.

Summary
A better understanding and representation of the burden of asthma and rhinitis in children can contribute to prevention strategies and improvements in the care of pediatric patients.
A Treatment Algorithm for High-Tone Pelvic Floor Dysfunction
Authors: Torosis Michele , Carey Erin , Christensen Kristin , Kaufman Melissa R. , Kenton Kimberly , Kotarinos Rhonda , Lai H. Henry , Lee Una , Lowder Jerry L. , Meister Melanie , Spitznagle Theresa , Wright Kelly , Ackerman A. Lenore 
Published: February 2024

OBJECTIVE:
To develop evidence- and consensus-based clinical practice guidelines for management of high-tone pelvic floor dysfunction (HTPFD). HTPFD is a neuromuscular disorder of the pelvic floor characterized by non-relaxing pelvic floor muscles, resulting in lower urinary tract and defecatory symptoms, sexual dysfunction, and pelvic pain. Despite affecting 80% of women with chronic pelvic pain, there are no uniformly accepted guidelines to direct the management of these patients.

METHODS:
A Delphi method of consensus development was used, comprising three survey rounds administered anonymously via web-based platform (Qualtrics XM) to national experts in the field of HTPFD recruited through targeted invitation between September and December 2021. Eleven experts participated with backgrounds in urology, urogynecology, minimally invasive gynecology, and pelvic floor physical therapy (PFPT) participated. Panelists were asked to rate their agreement with rated evidence-based statements regarding HTPFD treatment. Statements reaching consensus were used to generate a consensus treatment algorithm.

RESULTS:
A total of 31 statements were reviewed by group members at the first Delphi round with 10 statements reaching consensus. 28 statements were reposed in the second round with 17 reaching consensus. The putative algorithm met clinical consensus in the third round. There was universal agreement for PFPT as first-line treatment for HTPFD. If satisfactory symptom improvement is reached with PFPT, the patient can be discharged with a home exercise program. If no improvement after PFPT, second-line options include trigger or tender point injections, vaginal muscle relaxants, and cognitive behavioral therapy, all of which can also be used in conjunction with PFPT. Onabotulinumtoxin A injections should be used as third line with symptom assessment after 2–4 weeks. There was universal agreement that sacral neuromodulation is fourth-line intervention. The largest identified barrier to care for these patients is access to PFPT. For patients who cannot access PFPT, experts recommend at-home, guided pelvic floor relaxation, self-massage with vaginal wands, and virtual PFPT visits.

CONCLUSION:
A stepwise approach to the treatment of HTPFD is recommended, with patients often necessitating multiple lines of treatment either sequentially or in conjunction. However, PFPT should be offered first line.
Use of Direct-Acting Anticoagulants (DOAC) Among Hip Fracture Patients Is Not an Indication to Delay Surgical Intervention.
Authors: Brameier Devon T. , Tischler Eric H. , Ottesen Taylor D. , McTague Michael F. , Appleton Paul T. , Harris Mitchel B. , Weaver Michael J. , Suneja Nishant 
Published: February 2024

OBJECTIVES:
To compare outcomes in patients on direct oral anticoagulants (DOAC) treated within 48 hours of last preoperative dose to those with surgical delays >48 hours.

DESIGN:
Retrospective cohort study.

Setting:
Three academic Level 1 trauma centers.

Patient Selection Criteria:
Patients aged 65+ year old on DOACs prior to hip fracture treated between 2010-2018. Patients were excluded if: last DOAC dose was >24 hours prior to admission, patient suffered from polytrauma, and/or delay to surgery was not attributed to DOAC.

Outcome Measures and Comparisons:
Primary outcome measures were the post-operative complication rate as determined by diagnosis of deep venous thrombosis (DVT) or pulmonary embolus (PE), wound breakdown, drainage, or infection. Secondary outcomes included transfusion requirement, perioperative bleeding, length of stay, reoperation rates, readmission rates, and mortality.

RESULTS:
205 patients were included in the study, with a mean cohort age of 81.9 years (65-100 years), 64% (132/205) female, and a mean CCI of 6.4 (2-20). No significant difference was observed among age, gender, CCI, or fracture pattern between cohorts (p > 0.05 for all comparisons). 71 patients had surgery <48 hours following final preoperative DOAC dose; 134 patients had surgery >48 hours after. No significant difference in complication rate between the two cohorts was observed (p = 0.30). Patients with delayed surgical management were more likely to require transfusion (OR 2.39, 95% CI [1.05, 5.44]; p=0.04). Patients with early surgical management had significantly shorter lengths of stay (5.9 days vs 7.6 days, p<0.005). There was no difference in estimated blood loss, anemia, reoperations, readmissions, 90-day mortality, or 1-year mortality (p > 0.05 for all comparisons).

CONCLUSION:
Geriatric hip fracture patients who underwent surgical management within 48 hours of their last preoperative DOAC dose required less transfusions and had decreased length of stay, with comparable mortality and complication rates compared to patients with surgery delayed beyond 48 hours. Providers should consider early intervention in this population rather than adherence to elective procedure guidelines.
Electroacupuncture improves cognitive function in a rat model of mild traumatic brain injury by regulating the SIRT-1/PGC-1α/mitochondrial pathway
Authors: Jin Bo , Gao Yemei , Fu Yixian , Zhang Suxin , Zhang Ke , Su Yibing 
Published: February 2024

AbstractBackground:Mild traumatic brain injury (mTBI) is a common neurological trauma that can lead to cognitive impairment. The sirtuin-1 (SIRT-1)/peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) pathway has been reported to have neuroprotective effects in rats with craniocerebral injury. We evaluated potential mechanisms underlying electroacupuncture-mediated recovery of cognitive function after mTBI, focusing on the SIRT-1/PGC-1α/mitochondrial pathway.Methods:We included forty 6-week-old male Sprague-Dawley rats in this study. Rats were randomly divided into four groups: controlled cortical impactor (CCI,n= 10), sham operation (sham,n= 10), electroacupuncture-treated CCI (CCI+EA,n= 10), and electroacupuncture-treated sham (sham+EA,n= 10) group. Randomization was performed by assigning a random number to each rat and using a random number table. The mTBI rat model was established using a controllable cortical impactor. Electroacupuncture therapy was performed on the back of rats, by inserting acupuncture needles to the specific acupoints and setting appropriate parameters for treatment. We evaluated spatial learning and memory functions with the Morris water maze test. We performed quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, adenosine triphosphate (ATP) determination, and mitochondrial respiratory chain complex I (MRCC I) determination on rat hippocampal tissue. We analyzed SIRT-1/PGC-1α expression levels and the results of mitochondrial function assays, and compared differences between groups using bilateral Student’st-tests.Results:Compared with the sham group, SIRT-1/PGC-1α expression was downregulated in the hippocampus of CCI group (P<0.01). Although this expression was upregulated following electroacupuncture, it did not reach the levels observed in the sham group (P<0.05). Compared with the sham group, MRCC I and ATP levels in the CCI group were significantly reduced, and increased after electroacupuncture (P<0.01). In the Morris water maze, electroacupuncture reduced the incubation period of rats and increased average speed and number of crossing platforms (P<0.05).Conclusion:Electroacupuncture may improve cognitive function in the mTBI rat model by regulating the SIRT-1/PGC-1α/mitochondrial pathway.
Circulating cell-free DNA is elevated in postmenopausal compared with pre- and perimenopausal women
Authors: Fisher Teagan , Powell Elyse , Yuwono Nicole L. , Ford Caroline E. , Warton Kristina 
Published: February 2024

Abstract

Objective
With the rising use of circulating cell-free DNA (cirDNA) liquid biopsies for disease screening, it is important to understand biological differences that may impact the accuracy of cirDNA-based clinical tests. Although a number of biological factors have been researched, the relationship between menopause and cirDNA has not been thoroughly investigated. We aimed to compare plasma cirDNA concentration and DNA fragment integrity in healthy women pre- and postmenopause.

Methods
Blood was collected from healthy female volunteers 40 years and older. cirDNA was extracted from plasma (n = 52) and quantified by quantitative polymerase chain reaction (n = 47; 26 premenopause, mean age—46 y; 21 postmenopause, mean age—59 y). cirDNA concentration was quantitated using an ALU repetitive sequence with a 115-base-pair (bp) product (ALU-115), and long cirDNA fragments were quantitated using an ALU repetitive sequence with a 247-bp product (ALU-247). cirDNA integrity was expressed as a ratio of ALU-247 over ALU-115. Mann-Whitney U test was used to compare pre- and postmenopause qPCR results, and a two-tailed, unpaired t test was undertaken to compare the integrity ratio between the two groups.

Results
Postmenopause plasma samples were found to have a significantly higher cirDNA concentration (P < 0.0001, premenopause: mean, 3.10 ± 1.84 ng/mL; median, 2.90 ng/mL; postmenopause: mean, 5.28 ± 2.76 ng/mL; median, 4.56 ng/mL) and significantly higher concentration of long-stranded cirDNA fragments (P = 0.0033, premenopause: mean, 1.06 ± 0.48 ng/mL; median, 0.96 ng/mL; postmenopause: mean, 1.69 ± 0.89 ng/mL; median, 1.48 ng/mL). There was no significant difference in the integrity ratio between the groups (P = 0.1788).

Conclusions
Plasma cirDNA concentrations are higher in postmenopausal women. This has important implications in cirDNA liquid biopsy development and screening, especially for diseases such as cancer where the majority of cases are diagnosed postmenopause.
Age at natural or surgical menopause, all-cause mortality, and lifespan among postmenopausal women in the United States
Authors: Xing Zailing , Kirby Russell S. 
Published: February 2024

Abstract

Objective
This study investigated the association of age at natural menopause with or without undergoing hysterectomy and/or bilateral oophorectomy after menopause and age at surgical menopause with all-cause mortality and lifespan in postmenopausal women.

Methods
The data stemmed from the National Health and Nutrition Examination Survey (NHANES) (1999-2018) and NHANES III (1988-1994), including 14,161 postmenopausal women over 40. Cox proportional hazard models were used to estimate unadjusted and adjusted hazard ratios (HRs) (95% confidence intervals [CIs]). We also used Cox proportional hazard models with penalized splines to depict the association between continuous age at menopause and all-cause mortality and nonparametric regression with smoothing splines to illustrate the association between age at menopause and lifespan in deceased participants.

Results
The adjusted HRs (95% CIs) for age at natural menopause of <40, 40 to 44, and 55+ years in women without undergoing hysterectomy or bilateral oophorectomy after menopause were 1.48 (1.15-1.91), 1.16 (1.00-1.35), and 0.91 (0.77-1.07) compared with age at natural menopause of 45 to 54, respectively. The respective HRs (95% CIs) for age at surgical menopause were 1.39 (1.11-1.75), 1.09 (0.86-1.38), and 0.83 (0.53-1.32). However, no significant association was found between age at natural menopause and all-cause mortality among women undergoing hysterectomy and/or bilateral oophorectomy after menopause. When treated as continuous variables, age at natural menopause without undergoing hysterectomy or bilateral oophorectomy after menopause presented inverse and nonlinear associations with all-cause mortality, whereas age at surgical menopause was linearly inversely associated with all-cause mortality. The association between age at menopause and lifespan was linearly positive regardless of menopausal type.

Conclusion
Young age at menopause was associated with increased risks of all-cause mortality. The later menopause age was related to a longer lifespan.
Noninvasive pediatric blood pressure assessment: exploring the clinicians’ perspective
Authors: Stewart Natalie P. , Quinlan Catherine , Best Stephanie , Mynard Jonathan P. 
Published: February 2024

Background
Obtaining accurate and reliable blood pressure (BP) readings in pediatric patients is challenging, given difficulties in adhering to measurement guidelines, limited device validation and variable patient cooperation. This study aimed to investigate clinicians’ perspectives surrounding noninvasive pediatric BP assessment to identify opportunities for improvement in BP technology and clinical practice.

Method
Based on an adapted version of the extended Technology Acceptance Model 2, semi-structured interviews were conducted with clinicians involved in noninvasive pediatric BP assessment in a major Australian children’s hospital. Transcripts were analyzed thematically and guided by Technology Acceptance Model 2.

Results
Clinician responses (n = 20) revealed that poor patient tolerance of BP measurement resulting from excessive cuff inflation is a major hindrance to reliable pediatric BP assessment. Clinicians described low trust in BP readings from automated devices, often relating to poor patient tolerance to cuff inflation, thereby diminishing the clinical utility of these readings in informing treatment decisions. Auscultatory measurement was regarded as more trustworthy and better tolerated, but less convenient to perform as compared with oscillometric measurement.

Conclusion
A dissonance exists between (1) low trust and clinical utility of the most common and easy-to-use BP measurement approach (automated devices), versus (2) higher trust and clinical utility, but efficiency and user-related impediments, for the auscultatory method. Based on our results, we have developed the Blood Pressure Acceptance Model, which can be used to explain and predict clinicians’ acceptance of BP technology. Further work is needed to improve the tolerability and accuracy of automated BP devices in real-world pediatric settings.