bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of Various Sensing Mechanisms for Detecting Local and Atmospheric Greenhouse Gases: A Review
Authors: Bassous Nicole Joy , Rodriguez Ashly Corona , Leal Celina Ivonne Lomeli , Jung Hyun Young , Lee Chang Kee , Joo Sangwon , Kim Sumin , Yun Changhun , Hahm Myung Gwan , Ahn Myoung‐Hwan , Kim Sang‐Woo , Oh Young Suk , Shin Su Ryon 
Published: October 2023

AbstractElucidating the capital mechanism for detecting greenhouse gases (GHGs) in the atmosphere, based on sensitivity, performance, and cost‐effectiveness, is challenging, but markedly needed in the presence of global climate change caused by GHG emissions and subsequent feedback. Often measured in units of Global Warming Potential (GWP), the GHGs are linked to climate change, especially due to their intrinsic tendencies to absorb heat energy. Hence, measures for reducing GHG emissions are implemented within the context of improving energy consumption; substituting high‐GHG output fuels for more neutral alternatives; trapping and sequestering carbon; and reconditioning agricultural processes. The extent to which these curtailment methods succeed hinges on GHG detection and quantification mechanisms. However, the universal determination of GHGs is constrained by the availability of sensors; this work, therefore, highlights sensor advantages/disadvantages and potential enrichment strategies. Herein, experimental developments in GHG sensing technologies (i.e., chemiresistive, electrochemical, infrared, optical, acoustic, calorimetric, and gas chromatographic sensors) are evaluated, in terms of approaching desirable features, such as sensitivity, selectivity, stability, accuracy, and low cost. This work underscores ongoing global research to produce universal, cost‐effective methods that, with high sensitivity, proffer accurate GHG readings to allay global warming, through comparisons of recent, up‐and‐coming sensor technologies.
Breaking the Axis‐Symmetry of a Single‐Wall Carbon Nanotube During Its Growth
Authors: Zhang Lili , Xu Ziwei , Feng Tian‐liang , He Maoshuai , Hansen Thomas Willum , Wagner Jakob Birkedal , Liu Chang , Cheng Hui‐Ming 
Published: October 2023

AbstractThe asymmetrical growth of a single‐wall carbon nanotube (SWCNT) by introducing a change of a local atomic structure, is usually inevitable and supposed to have a profound effect on the chirality control and property tailor. However, the breaking of the symmetry during SWCNT growth remains unexplored and its origins at the atomic‐scale are elusive. Here, environmental transmission electron microscopy is used to capture the process of breaking the symmetry of a growing SWCNT from a sub‐2‐nm platinum catalyst nanoparticle in real‐time, demonstrating that topological defects formed on the side of a SWCNT can serve as a buffer for stress release and inherently break its axis‐symmetrical growth. Atomic‐level details reveal the importance of the tube‐catalyst interface and how the atom rearrangement of the solid‐state platinum catalyst around the interface influences the final tubular structure. The active sites responsible for trapping carbon dimers and providing enough driving force for carbon incorporation and asymmetric growth are shown to be low‐coordination step edges, as confirmed by theoretical simulations.
Probable digenic inheritance of Diamond–Blackfan anemia
Authors: Furuta Yutaka , Tinker Rory J , Gulsevin Alican , Neumann Serena M. , Hamid Rizwan , Cogan Joy D. , Rives Lynette , Liu Qi , Chen Hua‐Chang , Joos Karen M. , Phillips John A. ,   the Undiagnosed Diseases Network
Published: October 2023

AbstractA 26‐year‐old female proband with a clinical diagnosis and consistent phenotype of Diamond–Blackfan anemia (DBA, OMIM 105650) without an identified genotype was referred to the Undiagnosed Diseases Network. DBA is classically associated with monoallelic variants that have an autosomal‐dominant or ‐recessive mode of inheritance. Intriguingly, her case was solved by a detection of a digenic interaction between non‐allelic RPS19 and RPL27 variants. This was confirmed with a machine learning structural model, co‐segregation analysis, and RNA sequencing. This is the first report of DBA caused by a digenic effect of two non‐allelic variants demonstrated by machine learning structural model. This case suggests that atypical phenotypic presentations of DBA may be caused by digenic inheritance in some individuals. We also conclude that a machine learning structural model can be useful in detecting digenic models of possible interactions between products encoded by alleles of different genes inherited from non‐affected carrier parents that can result in DBA with an unrealized 25% recurrence risk.
Diagnostic Utility of Cerebrospinal Fluid Biomarkers in Patients with Rapidly Progressive Dementia
Authors: Kuchenbecker Lindsey A. , Tipton Philip W. , Martens Yuka , Brier Matthew R. , Satyadev Nihal , Dunham S. Richard , Lazar Evelyn B. , Dacquel Maxwell V. , Henson Rachel L. , Bu Guojun , Geschwind Michael D. , Morris John C. , Schindler Suzanne E. , Herries Elizabeth , Graff‐Radford Neill R. , Day Gregory S. 
Published: October 2023

ObjectiveThis study was undertaken to apply established and emerging cerebrospinal fluid (CSF) biomarkers to improve diagnostic accuracy in patients with rapidly progressive dementia (RPD). Overlap in clinical presentation and results of diagnostic tests confounds etiologic diagnosis in patients with RPD. Objective measures are needed to improve diagnostic accuracy and to recognize patients with potentially treatment‐responsive causes of RPD.MethodsBiomarkers of Alzheimer disease neuropathology (amyloid‐β 42/40 ratio, phosphorylated tau [p‐tau181, p‐tau231]), neuroaxonal/neuronal injury (neurofilament light chain [NfL], visinin‐like protein‐1 [VILIP‐1], total tau), neuroinflammation (chitinase‐3‐like protein [YKL‐40], soluble triggering receptor expressed on myeloid cells 2 [sTREM2], glial fibrillary acidic protein [GFAP], monocyte chemoattractant protein‐1 [MCP‐1]), and synaptic dysfunction (synaptosomal‐associated protein 25kDa, neurogranin) were measured in CSF obtained at presentation from 78 prospectively accrued patients with RPD due to neurodegenerative, vascular, and autoimmune/inflammatory diseases; 35 age‐ and sex‐matched patients with typically progressive neurodegenerative disease; and 72 cognitively normal controls. Biomarker levels were compared across etiologic diagnoses, by potential treatment responsiveness, and between patients with typical and rapidly progressive presentations of neurodegenerative disease.ResultsAlzheimer disease biomarkers were associated with neurodegenerative causes of RPD. High NfL, sTREM2, and YKL‐40 and low VILIP‐1 identified patients with autoimmune/inflammatory diseases. MCP‐1 levels were highest in patients with vascular causes of RPD. A multivariate model including GFAP, MCP‐1, p‐tau181, and sTREM2 identified the 44 patients with treatment‐responsive causes of RPD with 89% accuracy. Minimal differences were observed between typical and rapidly progressive presentations of neurodegenerative disease.InterpretationSelected CSF biomarkers at presentation were associated with etiologic diagnoses and treatment responsiveness in patients with heterogeneous causes of RPD. The ability of cross‐sectional biomarkers to inform upon mechanisms that drive rapidly progressive neurodegenerative disease is less clear. ANN NEUROL 2024;95:299–313
Seipin overexpression attenuates cerebral ischemia‐reperfusion injury via preventing apoptosis and autophagy
Authors: Zhu Xiaoxi , An Xiaoqiong , Chen Ming , Guo Dongfen , Xie Peng , Wang Bi , Huang Zhi , Yu Wenfeng 
Published: October 2023

AbstractBackgroundIschemic cerebrovascular disease (ICVD) is one of three fatal diseases in humans, along with heart disease and malignant tumors. Cerebral ischemia/reperfusion injury (CI/RI) is the primary cause of ICVD. Recently, seipin was reported to be crucial for lipid droplet formation, hepatic steatosis, and axonal atrophy. However, the function and mechanism of seipin in CI/RI has not been explicitly stated.MethodsOxygen–glucose deprivation/reoxygenation (OGD/R) hippocampal neuron cell line (HT‐22) and middle cerebral artery occlusion (MCAO) in rats were established. The levels of apoptosis‐ and autophagy‐related proteins and seipin were confirmed by western blot. Cell proliferation was assessed with CCK‐8, and ischemic infarction and pathological structure were monitored by TTC and H&E staining, and tissue apoptosis was assessed through TUNEL assay.ResultsThe proliferative activity was decreased, and apoptosis and autophagy pathways could also be induced in the OGD/R HT‐22 cells. Seipin overexpression accelerated viability and inhibited apoptosis and autophagy in the OGD/R HT‐22 cells. Moreover, the data revealed that seipin overexpression could also attenuate cerebral infarction, apoptosis. Autophagy pathways could be repressed by seipin in the MCAO rats.ConclusionSeipin has a protective role against CI/RI in rats, and its mechanism might be relevant to the suppression of apoptosis and autophagy, suggesting that seipin might be a latent target for CI/RI.
How do stakeholder groups make sense of sustainability: Analysing differences in the complexity of their cognitive frames
Authors: Preuss Lutz , Fischer Isabel , Arora Bimal 
Published: October 2023

AbstractCharacterizing major sustainability issues as ‘grand challenges’ has led to a call for collaboration among heterogeneous stakeholder groups, not least in multi‐stakeholder initiatives (MSIs). Research into MSIs has made substantial progress in understanding their workings; yet, it is still criticized for remaining undertheorized, echoing a criticism of management studies generally as paying insufficient attention to the micro–macro divide. Hence, we examined differences between stakeholder groups in the complexity of their cognitive frames on the topic of sustainability. We analysed 265 cognitive frames across four stakeholder groups (business, government, NGO, education). Analysing these frames in terms of the two dimensions of cognitive complexity—differentiation and integration—we found statistically significant differences in frame complexity between stakeholder groups. These micro‐level cognitive differences can explain macro‐level problems in stakeholder engagement and communication. Hence, we conclude by discussing the implications of our findings for the enhancement of the effectiveness of MSIs.
Cancer vaccines in the clinic
Authors: Janes Morgan E. , Gottlieb Alexander P. , Park Kyung Soo , Zhao Zongmin , Mitragotri Samir 
Published: October 2023

AbstractVaccines are an important tool in the rapidly evolving repertoire of immunotherapies in oncology. Although cancer vaccines have been investigated for over 30 years, very few have achieved meaningful clinical success. However, recent advances in areas such antigen identification, formulation development and manufacturing, combination therapy regimens, and indication and patient selection hold promise to reinvigorate the field. Here, we provide a timely update on the clinical status of cancer vaccines. We identify and critically analyze 360 active trials of cancer vaccines according to delivery vehicle, antigen type, indication, and other metrics, as well as highlight eight globally approved products. Finally, we discuss current limitations and future applications for clinical translation of cancer vaccines.
ChemInform Abstract: Chemical Studies on the Nyctinastic Leaf‐Movement Regulated by a Biological Clock
Authors: Ueda Minoru , Yamamura Shosuke 
Published: October 2023

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Reactions with Catalytic Antibodies
Authors: Hilvert Donald 
Published: October 2023

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Determinants of sustainability reporting: A systematic literature review
Authors: Arkoh Paul , Costantini Antonio , Scarpa Francesco 
Published: October 2023

AbstractSustainability reporting has been widely acknowledged as a crucial corporate sustainability practice and recently received increasing attention from regulators, standard‐setters, practitioners, and researchers. Motivated by the abundance of work, and the variety of theoretical perspectives and existing evidence, this paper explores how the research on sustainability reporting determinants has developed over time and what is known and not known about this topic. To address this question, we conducted a systematic literature review of articles on sustainability reporting determinants published in ABS‐ranked journals between 2002 and 2021. Building on Lozano et al. (2015) framework of corporate sustainability theories, our findings provide an updated overview of factors driving sustainability reporting and the determinants still under debate. Furthermore, to fill existing gaps and inspire future research developments, findings suggest further work focus on non‐listed companies, environmentally sensitive industries, underexplored geographical areas, and qualitative methods. Finally, the paper has implications for managers and policymakers.
Impact of preoperative self‐expandable metal stent on benign hepaticojejunostomy anastomotic stricture after pancreaticoduodenectomy
Authors: Mie Takafumi , Sasaki Takashi , Kobayashi Kosuke , Takeda Tsuyoshi , Okamoto Takeshi , Kasuga Akiyoshi , Inoue Yosuke , Takahashi Yu , Saiura Akio , Sasahira Naoki 
Published: October 2023

AbstractObjectivesHepaticojejunostomy anastomotic stricture (HJAS) is a serious adverse event of pancreaticoduodenectomy. Preoperative biliary drainage with a self‐expandable metal stent (SEMS) is often performed before pancreaticoduodenectomy. The purpose of this study is to evaluate the risk factors and impact of preoperative SEMS placement on developing benign HJAS after pancreaticoduodenectomy.MethodsWe retrospectively analyzed consecutive patients who underwent pancreatoduodenectomy at our institution between July 2014 and June 2020. Risk factors for benign HJAS were identified using univariate and multivariate logistic regression analysis. We also compared outcomes of preoperative biliary drainage using SEMS and non‐SEMS.ResultsOf the 626 included patients, benign HJAS occurred in 36 patients (5.8%). The median follow‐up time was 36.7 months (interquartile range, 25.4–57.4 months). Multivariate logistic regression analysis revealed that lack of preoperative biliary drainage, preoperative bile duct diameter <5 mm, and former or current smoking were independent predictors of benign HJAS. In the preoperative biliary drainage group, the rate of preoperative bile duct diameter <5 mm was significantly lower in the SEMS group than in the non‐SEMS group (2.0% vs. 12.8%, p = 0.04).ConclusionsPreoperative biliary drainage with SEMS may be useful to maintain bile duct diameter ≥5 mm and to reduce benign HJAS as a result.
Fungal community dissimilarity predicts plant–soil feedback strength in a lowland tropical forest
Authors: Delavaux Camille S. , Angst Janika K. , Espinosa Hilario , Brown Makenna , Petticord Daniel F. , Schroeder John W. , Broders Kirk , Herre Edward A. , Bever James D. , Crowther Thomas W. 
Published: October 2023

AbstractSoil microbes impact plant community structure and diversity through plant–soil feedbacks. However, linking the relative abundance of plant pathogens and mutualists to differential plant recruitment remains challenging. Here, we tested for microbial mediation of pairwise feedback using a reciprocal transplant experiment in a lowland tropical forest in Panama paired with amplicon sequencing of soil and roots. We found evidence that plant species identity alters the microbial community, and these changes in microbial composition alter subsequent growth and survival of conspecific plants. We also found that greater community dissimilarity between species in their arbuscular mycorrhizal and nonpathogenic fungi predicted increased positive feedback. Finally, we identified specific microbial taxa across our target functional groups that differentially accumulated under conspecific settings. Collectively, these findings clarify how soil pathogens and mutualists mediate net feedback effects on plant recruitment, with implications for management and restoration.
Coordination Adaptable Networks: Introducing Vitrimer Properties Using Dynamic Coordination Bonds
Authors: Murali Meenu , Manoury Eric , Poli Rinaldo 
Published: October 2023

AbstractCoordination adaptable networks (CooANs) may be obtained by combination of ligand‐functionalized polymers and metal ions or clusters when the crosslink migration by ligand exchange with available free ligands in the polymer matrix is facile. These materials may be called “coordination vitrimers” if proven to follow an associative ligand exchange mechanism. This review presents various types of CooANs, classified according to the nature of the metal‐binding functions, e. g. imine, imidazoles, pyridines as L‐type ligands; catecholates, thiolates, carboxylates as X‐type ligands. Particular attention is placed on the crosslink migration mechanism.
Thermal properties and applications of form‐stable phase change materials for thermal energy storage and thermal management: A review
Authors: Fu Tingwei , Wang Wenze , Fang Guiyin 
Published: October 2023

AbstractPhase change materials possess the merits of high latent heat and a small range of phase change temperature variation. Therefore, there are great prospects for applying in heat energy storage and thermal management. However, the commonly used solid‐liquid phase change materials are prone to leakage as the phase change process occurs. To address this drawback of solid‐liquid phase change materials, researchers have developed form‐stable phase change materials. There are three main strategies for preparation of form‐stable phase change materials. The objectives of this article are: (1) The form‐stable phase change materials are classified according to the preparation strategy, and the properties of each class of form‐stable phase change materials are presented. (2) The advantages and disadvantages of form‐stable phase change materials are also discussed. (3) It is also summarized that the methods to improve the drawbacks and enhance the characteristics of form‐stable phase change materials. (4) Moreover, the multifunctional form‐stable phase change materials are also described. (5) Finally, applications of form‐stable phase change materials are analyzed and discussed.
Pre‐rehabilitation interventions for patients with head and neck cancers: A systematic review and meta‐analysis
Authors: Seth Ishith , Bulloch Gabriella , Qin Kirby R. , Xie Yi , Sebastian Benjamin , Liew Hann , Rozen Warren Matthew , Lee Chun Hin Angus 
Published: October 2023

AbstractObjectiveTo investigate the effect of pre‐rehabilitation interventions such as nutrition and exercise for patients with head and neck cancer (HNC).MethodsWeb of Science, PubMed, Scopus, Google Scholar, and Cochrane databases were searched up to December 2022. Quality of life, length of hospital stay, postoperative complications, change in body mass index or muscle mass, and functional assessments were the primary outcomes. PRISMA guidelines were adhered to, and the study was registered on PROSPERO. The Cochrane Collaboration tool and Newcastle Ottawa scale assessed the quality of included studies. Pooled data are presented as odds ratios (OR) and 95% confidence intervals (CI). Analysis was conducted using RevMan5.4.ResultsA total of 31 articles were included for quantitative analysis and 15 for qualitative synthesis. Nutrition alone resulted in significant weight retention (2.60; 2.32, 2.88, p < 0.00001), length of stay (−4.00; −6.87, −1.13), p = 0.0006) and complications (0.64; 0.49, 0.83, p = 0.0009). Nutrition and psychoeducation resulted in a significant reduction in mortality rate (0.70; 0.49, 1.00, p = 0.05 and 0.60; 0.48, 0.74, p < 0.00001), and exercise resulted in a significant reduction in dysphagia (0.55; 0.35, 0.87, p = 0.01). Exercise with nutrition resulted in significant improvements in weight loss, length of stay, complications, and dysphagia. Randomized controlled trials (RCTs) had a moderate risk of bias and cohort studies were of fair to good quality.ConclusionPrehabilitation programs based on exercise, nutrition, or psychoeducation demonstrated improved post‐interventional outcomes in HNC, such as quality of life, and mortality and morbidity. Studies with longer follow‐ups and larger sample sizes, and investigations comparing nutritional supplements with exercise programs are needed.
The neutrophil‐to‐lymphocyte ratio in salivary gland cancers treated with pembrolizumab
Authors: Lee Rex H. , Truong Angeline , Wu Xin , Kang Hyunseok , Algazi Alain P. , El‐Sayed Ivan H. , George Jonathan R. , Heaton Chase M. , Ryan William R. , Ha Patrick K. , Wai Katherine C. 
Published: October 2023

AbstractBackgroundA minority of patients with recurrent/metastatic (R/M) salivary gland cancers (SGCs) benefit from immune checkpoint inhibitors (ICIs), necessitating reliable biomarkers for ICI response prediction.MethodsRetrospective observational study of R/M SGC patients treated with pembrolizumab between 2016 and 2022, with a primary outcome of 6‐month progression‐free survival (PFS) and secondary outcome of 2‐year overall survival (OS). Univariate and multivariable Cox proportional hazards models were employed.ResultsTwenty R/M SGC patients were included. After adjustment, NLR as a continuous variable was independently associated with 6‐month PFS (HR 1.30, 95% CI 1.10–1.54, p = 0.002) and 2‐year OS (HR 1.33, 95% CI 1.07–1.66, p = 0.010). Similarly, NLR ≥ 5 was associated with higher hazards of progression at 6 months (HR 12.85, 95% CI 2.17–76.16, p = 0.005) and death at 2 years (HR 11.25, 95% CI 1.67–75.77, p = 0.013).ConclusionsHigher pretreatment NLR was independently associated with inferior 6‐month PFS and 2‐year OS in pembrolizumab‐treated R/M SGC patients.