bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterologous expression of PtAAS1 reveals the metabolic potential of the common plant metabolite phenylacetaldehyde for auxin synthesis in planta
Authors: Günther Jan , Halitschke Rayko , Gershenzon Jonathan , Burow Meike 
Published: November 2023

AbstractAromatic aldehydes and amines are common plant metabolites involved in several specialized metabolite biosynthesis pathways. Recently, we showed that the aromatic aldehyde synthase PtAAS1 and the aromatic amino acid decarboxylase PtAADC1 contribute to the herbivory‐induced formation of volatile 2‐phenylethanol and its glucoside 2‐phenylethyl‐β‐D‐glucopyranoside in Populus trichocarpa. To unravel alternative metabolic fates of phenylacetaldehyde and 2‐phenylethylamine beyond alcohol and alcohol glucoside formation, we heterologously expressed PtAAS1 and PtAADC1 in Nicotiana benthamiana and analyzed plant extracts using untargeted LC‐qTOF‐MS and targeted LC–MS/MS analysis. While the metabolomes of PtAADC1‐expressing plants did not significantly differ from those of control plants, expression of PtAAS1 resulted in the accumulation of phenylacetic acid (PAA) and PAA‐amino acid conjugates, identified as PAA‐aspartate and PAA‐glutamate. Herbivory‐damaged poplar leaves revealed significantly induced accumulation of PAA‐Asp, while levels of PAA remained unaltered upon herbivory. Transcriptome analysis showed that members of auxin‐amido synthetase GH3 genes involved in the conjugation of auxins with amino acids were significantly upregulated upon herbivory in P. trichocarpa leaves. Overall, our data indicates that phenylacetaldehyde generated by poplar PtAAS1 serves as a hub metabolite linking the biosynthesis of volatile, non‐volatile herbivory‐induced specialized metabolites, and phytohormones, suggesting that plant growth and defense can be balanced on a metabolic level.
The mediating role of religion and loneliness on the association between reminiscence functions and depression: a call to advance older adults' mental health
Authors: Abu Khait Abdallah , Menger Austin , Rababa Mohammad , Moldovan Theodora , Lazenby Mark , Shellman Juliette 
Published: November 2023

AbstractBackgroundCurrent literature lacks evidence about the relationship between reminiscence functions and depression and the mediating role of clinical constructs such as loneliness and religion. The study aimed to examine the mediating effects of loneliness and religion on the association between reminiscence functions and depression in a sample of older Jordanian adults.MethodsAn anonymous online cross‐sectional survey was employed to collect data from 365 older Jordanian adults. Convenience and snowball sampling methods were used to recruit participants through social media.ResultsIn the depression model, Bitterness Revival and Intimacy Maintenance factors, educational level, and Intrinsic Religiosity were statistically significant predictors of depression. Bitterness Revival and Intimacy Maintenance factors, work sector, and Intrinsic Religiosity were statistically significant predictors of loneliness. Loneliness has a negative, partial mediating effect on Intimacy Maintenance and depression.ConclusionDepression caused by significant losses in the Arab Jordanian environment might be mitigated by Intimacy Maintenance by reducing feelings of loneliness. Understanding how Intimacy Maintenance correlates with depression through loneliness could help psychiatric nurses develop psychosocial interventions that reduce depression among older adults.
Does participation predict support for place brands? An analysis of the relationship between stakeholder involvement and brand citizenship behavior
Authors: Ripoll González Laura , Klijn Erik Hans , Eshuis Jasper , Braun Erik 
Published: November 2023

AbstractThis article studies in how far participation of stakeholders enhances their active support for place brands, conceptualized in this study as Brand Citizenship Behavior (BCB). Combining insights from governance and branding theory this article uses survey data (N = 162) among stakeholders involved in branding processes of two Dutch regions. The analysis shows that more intense participation in the development of the brand is related to more BCB. Beyond participation, perceived value of the brand for stakeholders and degree of place identity (identification with place) also positively relate to brand citizenship behavior. The findings not only confirm the importance of participation in achieving support for public brands, but also provide insight into the role of affective factors (identification) and interest‐based factors (value of the brand for the stakeholder) on BCB.
Transient hypogammaglobulinemia of infancy and unclassified syndromic immunodeficiencies are highly common in oesophageal atresia patients
Authors: Ulman Hilmican , Aygün Ayşe , Çağlar Deniz , Dökümcü Zafer , Topyıldız Ezgi , Erdener Ata , Aksu Güzide , Karaca Neslihan Edeer , Özcan Coşkun , Kütükçüler Necil 
Published: November 2023

AbstractDue to the high rate of post‐operative sepsis and other infectious complications, a routine immunological screening protocol has been initiated since 2015 in our paediatric surgery clinic for all patients admitted with oesophageal atresia (EA) and warrant a delayed definitive treatment. In our study, we aimed to evaluate the immunodeficiencies in EA patients, by comparing them to healthy age‐matched controls. As a prospective cohort study, EA patients admitted between 2015 and 2022, who had their definitive operation after the newborn period (>28 days of age) were included. On admission, serum concentrations of IgG, IgA, IgM, lymphocyte subset levels, C3 and C4 levels, specific IgG antibody responses against hepatitis B, hepatitis A, measles, varicella zoster were evaluated. The patients were age‐matched with healthy controls to compare the results and followed up until three years of age. If a humoral immunodeficiency was detected, intravenous immunoglobulin treatment was administered before major oesophageal surgery and during follow‐up. 31 EA patients (18 M/13F) with a mean age of 13.3 ± 9.0 months were compared with 40 age‐matched healthy controls. Mean serum IgG levels were found to be statistically lower than controls in all age groups (P < .05). Transient hypogammaglobulinemia of infancy (THI) and unclassified syndromic immunodeficiencies (USI) were found to be strikingly high, accounting for 29.0% and 22.5%, respectively, adding up to 51.5% of EA patients. This is the first study evaluating immunodeficiencies in EA patients found in the reviewed literature. More than half of EA patients that required delayed surgery had humoral immunodeficiency, so preoperative screening and immunology referral may improve patient outcomes.
Assessment of health‐related quality of life in patients with Chagas cardiomyopathy using Minnesota living with heart failure questionnaire: A validation study
Authors: Trindade Ana Flávia Vieira , Silva Whesley Tanor , Lima Vanessa Pereira , Mendonça Vanessa Amaral , Lacerda Ana Cristina Rodrigues , Ávila Matheus Ribeiro , de Oliveira Lucas Fróis Fernandes , de Almeida Igor Lucas Geraldo Izalino , Silva Keity Lamary Souza , de Oliveira Luciano Fonseca Lemos , Carvalho Liliany Mara Silva , da Cruz Ferreira Paulo Henrique , de Faria Sanny Cristina Castro , Mediano Mauro Felippe Felix , Figueiredo Pedro Henrique Scheidt , Costa Henrique Silveira 
Published: November 2023

AbstractObjectiveChagas cardiomyopathy (ChC) is the most severe clinical form of Chagas disease and, in association with psychosocial factors, can compromise the health‐related quality of life (HRQoL) of affected patients. To date, there is no specific instrument to assess the HRQoL of these patients, and the Minnesota Living with Heart Failure Questionnaire (MLwHFQ), specific for heart failure, is being used both in research and current clinical practice. Therefore, we aimed to verify the validity of the MLwHFQ in the assessment of HRQoL of patients with ChC.MethodsFifty patients with ChC (50.6 ± 10.1 years, NYHA I‐III) were evaluated. The MLwHFQ, Short‐Form of Health Survey (SF‐36), Beck Depression Inventory (BDI), and Human Activity Profile (HAP) were applied. All patients underwent echocardiography and Cardiopulmonary Exercise Testing (CPET).ResultsThe MLwHFQ score correlated with almost all SF‐36 domains (with r‐value ranging from −0.38 to −0.69), except pain (p = 0.118). The MLwHFQ score also correlated with the BDI score (r = 0.748; p < 0.001), HAP score (r = −0.558; p = 0.001), peak oxygen uptake (r = −0.352; p = 0.01), and left ventricular ejection fraction (r = −0.329; p = 0.021). There was no significant difference in the score found on the MLwHFQ among NYHA classes (p = 0.101), as well as between patients with systolic dysfunction (n = 30) and preserved cardiac function (n = 20) (p = 0.058). Similarly, there was no significant difference in the score found on the physical (p = 0.423) and mental (p = 0.858) components of SF‐36 between patients with systolic dysfunction and preserved cardiac function (p = 0.271 and p = 0.609, respectively). There was also no difference in the mental component of SF‐36 among NYHA classes (p = 0.673). However, the HRQoL using the physical component of SF‐36 was worse in advanced NYHA classes (p = 0.014).ConclusionMLwHF correlated with most SF‐36 HRQoL domains, depressive symptoms, physical activity, and systolic function and seems to be valid in assessing the HRQoL of ChC patients.
A DELAY OF GERMINATION 1 (DOG1)‐like protein regulates spore germination in the moss Physcomitrium patens
Authors: Vollmeister Evelyn , Phokas Alexandros , Meyberg Rabea , Böhm Clemens V. , Peter Marlies , Kohnert Eva , Yuan Jinhong , Grosche Christopher , Göttig Marco , Ullrich Kristian K. , Perroud Pierre‐François , Hiltbrunner Andreas , Kreutz Clemens , Coates Juliet C. , Rensing Stefan A. 
Published: November 2023

SUMMARYDELAY OF GERMINATION 1 is a key regulator of dormancy in flowering plants before seed germination. Bryophytes develop haploid spores with an analogous function to seeds. Here, we investigate whether DOG1 function during germination is conserved between bryophytes and flowering plants and analyse the underlying mechanism of DOG1 action in the moss Physcomitrium patens. Phylogenetic and in silico expression analyses were performed to identify and characterise DOG1 domain‐containing genes in P. patens. Germination assays were performed to characterise a Ppdog1‐like1 mutant, and replacement with AtDOG1 was carried out. Yeast two‐hybrid assays were used to test the interaction of the PpDOG1‐like protein with DELLA proteins from P. patens and A. thaliana. P. patens possesses nine DOG1 domain‐containing genes. The DOG1‐like protein PpDOG1‐L1 (Pp3c3_9650) interacts with PpDELLAa and PpDELLAb and the A. thaliana DELLA protein AtRGA in yeast. Protein truncations revealed the DOG1 domain as necessary and sufficient for interaction with PpDELLA proteins. Spores of Ppdog1‐l1 mutant germinate faster than wild type, but replacement with AtDOG1 reverses this effect. Our data demonstrate a role for the PpDOG1‐LIKE1 protein in moss spore germination, possibly alongside PpDELLAs. This suggests a conserved DOG1 domain function in germination, albeit with differential adaptation of regulatory networks in seed and spore germination.
A deeper look at low‐frequency contact ultrasonic debridement in the clinical management of patients with diabetic foot ulcers
Authors: Álvaro‐Afonso Francisco J. , Flores‐Escobar Sebastián , Sevillano‐Fernández David , García‐Álvarez Yolanda , García‐Madrid Marta , Lázaro‐Martínez José L. 
Published: November 2023

AbstractThe current study aimed to evaluate the dispersal of solution and microbes (aerosol) in the clinical environment during treatment with Low‐frequency contact ultrasonic debridement (LFCUD) with or without suction attachment in patients with diabetic foot ulcers (DFUs). We performed 20 treatments in 10 patients divided into two groups to receive the proposed LFCUD modalities. We measured the microbial load of the environment pre‐treatment (sample M1), during treatment with each LFCUD modality (sample M2) and post‐treatment (sample M3). The use of LFCUD debridement without a suction attachment results in significantly higher immediate contamination of the clinic environment than the suction attachment, particularly during the procedure (1.70 ± 0.98 log 10 CFU/mL versus 0.77 ± 0.85 log 10 CFU/mL, p = 0.035). When suction is not applied, there are statistically significant differences depending on whether the DFUs are neuropathic or neuroischemic, finding a greater number of microorganisms with high loads in neuropathic DFUs. We found a statistically significant positive correlation between wound area (r = 0.450, p = 0.047) and TBI (r = 0.651, p = 0.006) with the bacterial load during the LFCUD. Based on our results, we recommend using the personal protective equipment required to protect staff members and patients during treatment with LFCUD and using a suction attachment where clinically possible to reduce clinic environmental pollution, especially in neuropathic DFUs and those with larger areas.
Primes with a missing digit: Distribution in arithmetic progressions and an application in sieve theory
Authors: Nath Kunjakanan 
Published: November 2023

AbstractWe prove Bombieri–Vinogradov type theorems for primes with a missing digit in their ‐adic expansion for some large positive integer . The proof is based on the circle method, which relies on the Fourier structure of the integers with a missing digit and the exponential sums over primes in arithmetic progressions. Combining our results with the semi‐linear sieve, we obtain an upper bound and a lower bound of the correct order of magnitude for the number of primes of the form with a missing digit in a large odd base .
OptiQL: Robust Optimistic Locking for Memory-Optimized Indexes
Authors: Shi Ge , Yan Ziyi , Wang Tianzheng 
Published: November 2023

Modern memory-optimized indexes often use optimistic locks for concurrent accesses. Read operations can proceed optimistically without taking the lock, greatly improving performance on multicore CPUs. But this is at the cost of robustness against contention where many threads contend on a small set of locks, causing excessive cacheline invalidation, interconnect traffic and eventually performance collapse. Yet existing solutions often sacrifice desired properties such as compact 8-byte lock size and fairness among lock requesters.
This paper presents optimistic queuing lock (OptiQL), a new optimistic lock for database indexing to solve this problem. OptiQL extends the classic MCS lock---a fair, compact and robust mutual exclusion lock---with optimistic read capabilities for index workloads to achieve both robustness and high performance while maintaining various desirable properties. Evaluation using memory-optimized B+-trees on a 40-core, dual-socket server shows that OptiQL matches existing optimistic locks for read operations, while avoiding performance collapse under high contention.
SH2O: Efficient Data Access for Work-Sharing Databases
Authors: Sioulas Panagiotis , Mytilinis Ioannis , Ailamaki Anastasia 
Published: November 2023

Interactive applications require processing tens to hundreds of concurrent analytical queries within tight time constraints. In such setups, where high concurrency causes contention, work-sharing databases are critical for improving scalability and for bounding the increase in response time. However, as such databases share data access using full scans and expensive shared filters, they suffer from a data-access bottleneck that jeopardizes interactivity.
We present SH2O: a novel data-access operator that addresses the data-access bottleneck of work-sharing databases. SH2O is based on the idea that an access pattern based on judiciously selected multidimensional ranges can replace a set of shared filters. To exploit the idea in an efficient and scalable manner, SH2O uses a three-tier approach: i) it uses spatial indices to efficiently access the ranges without overfetching, ii) it uses an optimizer to choose which filters to replace such that it maximizes cost-benefit for index accesses, and iii) it exploits partitioning schemes and independently accesses each data partition to reduce the number of filters in the access pattern. Furthermore, we propose a tuning strategy that chooses a partitioning and indexing scheme that minimizes SH2O's cost for a target workload. Our evaluation shows a speedup of 1.8-22.2 for batches of hundreds of data-access-bound queries.
The Misinformation Threat: A Techno-Governance Approach for Curbing the Fake News of Tomorrow
Authors: Cassar Daniel 
Published: November 2023

Recent internationally relevant diplomatic and economic developments have placed a bright spotlight on the relevance of genuine and false claims. In a post-truth era, or as more commonly known, the era of fake news, an increasing interest has manifested in relation to how this phenomenon can and has been applied to thwart people's reasoning and behaviour. The advancements in modern technology have pushed scientists to question the scale and impact of fake news on humanity. Since technology has become closely integrated with the lives of humankind over the years, its pervasiveness is required to be taken into account to analyse how fake news is being generated and widely shared.
For a first-hand impression of the issue, a survey was designed and distributed to the general public to take part in. Additionally, a set of interviews were conducted with specialists from a number of fields in which participants expressed their views on the issue and their suggestions on curbing it. Despite differences in their views, a general consensus was reached that a multidisciplinary approach is needed to reduce the threat, and better educate and inform the public. In doing so, multiple entities and skilled individuals must be roped in to play their part in safeguarding information veracity and supporting end users.
The study also provides research insight into this impending threat that should give a clearer understanding of the fate of tomorrow's cyberspace as well as the societies we form a part of. The proposed recommendations, which combine both regulatory and technology fields, aim to bolster the capacity of nations and better equip governments in tackling the evolving state of fake news. It is envisioned that through these recommendations, societies move towards an age where both people and technology become part of the solution rather than the cause of such threats.
Racism, Stereotypes, and War
Authors: Mercer Jonathan 
Published: November 2023

Abstract
Racism systematically distorts policymakers’ analyses of their allies’ and adversaries’ capabilities, interests, and resolve, potentially leading to costly choices regarding war and peace. When policymakers hold racist beliefs, as they did in the Russo-Japanese War (1904–1905), their beliefs influence how they explain and predict their allies’ and adversaries’ behaviors. Reliance on racist stereotypes leads policymakers to inaccurate assessments. An analysis of the relationship between stereotypes, reputations, and bigotry indicates that reputations easily become stereotypes—which is discomforting to anyone who bases policy decisions on another's reputation or encourages policymakers to do so. International security scholars have largely overlooked the role of racism, assuming rational choices on the part of policymakers. Research demonstrates that this assumption is wrong.
To Punish or Protect? Local Leaders and Economic Coercion in China
Authors: Miura Kacie 
Published: November 2023

Abstract
During foreign policy disputes involving China and some of its most important economic partners, why do local leaders punish or protect foreign commercial actors? Understanding this variation is important because how local leaders treat foreign businesses can influence the overall effectiveness of the Chinese government's use of economic coercion against foreign states. Two variables help determine whether local leaders participate in economic retaliation: (1) whether they regard commercial ties to the targeted state as essential to achieving the economic growth necessary for career advancement; and (2) whether they are politically vulnerable, either because they lack powerful patrons or because their locality recently experienced social unrest. Economic importance creates incentives to protect foreign commercial interests, and political vulnerability provides incentives for local leaders to demonstrate their patriotic credentials through economic retaliation. Drawing on interviews with Chinese, Korean, and Japanese sources, an examination of local leader behavior in Chinese cities illuminates why they responded differently during foreign policy disputes with Japan in 2012 and South Korea in 2017.
Evolution of the English Language, Nonfiction, Near Death Experience Book Genre Over the Past Fifty Years
Authors: Bosco-Ruggiero Stephanie 
Published: November 2023

This study looks at the evolution of the nonfiction English language near death experience (NDE) book genre over the past 50 years. The key research aim was to identify subgenres of NDE books to better understand how the epistemology of NDEs has been shaped by the popular literature. The study employed a qualitative methodology and was both inductive and deductive. World Cat and Library of Congress databases were used to identify printed and digital books, as well as textbooks, published on the NDE topic. Each book was coded to classify it within a specific subgenre. Findings showed that the largest subgenre of English language NDE books has been the experiencer account, whether written in an autobiographical or biographical format. Other large subgenres have included scientific investigations, religiously oriented books (especially Christian), and books exploring the personal aftereffects of NDEs. Subgenres that have emerged in recent decades include compilations of “lessons” from NDEs, books written by neuroscientists, and books written by medical practitioners about patient experiences. The author concludes that public knowledge about NDEs has been greatly shaped by experiencer accounts published in books. Furthermore, the emergence of new subgenres of NDE books, and the growth of others, signals ongoing change in the epistemology of the phenomenon. Reflexive practice was central to the development of the final manuscript. Reflexivity is seamlessly integrated throughout the paper and demonstrates how the author’s familiarity with the book genre, and the NDE subject in general, shaped the development and conduct of this study.