bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of an Educational Booklet for The Healthy Eating Management of Diabetes Mellitus During Ramadan Fasting
Authors: Larasati Meirina Dwi , Muninggar Dian Luthfita Prasetya , Firmansyah Firmansyah 
Published: October 2023

Background: iabetics who decide on Ramadan fasting are at risk of complications such as hypoglycemia, hyperglycemia, ketosis, or dehydration. The strategy for prevention is to provide education about managing DM with healthy food intake, medication, and exercise during Ramadan fasting. Therefore, it is essential to develop the media to implement education.Research Methods: This research was a research and development method. The model used in developing an educational booklet consists of four stages: define, design, develop, and disseminate. The feasibility of growing media was analyzed by the content validity index (CVI) using I-CV and S-CVI to assess whether the item is relevant or not relevant to the index CVI>0,80. Research Result: Define is the first stage to analyze the need for media development; based on the results of an online survey of nutritionists, as many as 71% mentioned that there were no specific educational media on healthy eating management for DM during Ramadan fasting. Design and development of educational media include literature studies on healthy eating during Ramadan fasting for DM, containing food menus during Ramadan fasting—subsequent dissemination by assessment from experts and target subjects. The assessing subject's content validity index (CVI) was carried out using the I-CV and S-CVI. The average value of I-CV is 0.875, and the average value of S-CVI is 0.875, meaning that all parts of the content are relevant in providing information about healthy eating for DM during Ramadan fasting. The reliability test by the target subject obtained Cronbach's alpha value of 0.850 was reliable. Conclusion: This booklet can be used as an educational medium for pre-Ramadan education. Then, the researchers developed this booklet by considering and improving the booklet design, which was stated to be appropriate.
Effect of Peanut Addition (Arachis hypogea) On Organoleptic Properties, Nutritional Value, and AcceptabilitySnack Peanbars for Pregnant Women in the Working Area
Authors: Rohmi Khaerukiatul , Darawati Made , Chandradewi AASP , Widiada I gde narda 
Published: October 2023

Background: Snack bars, which are rectangular and contain all the nutrients humans need, can be a great option to meet the nutritional needs of pregnant women because pregnant women need a balanced and nutrient-rich intake to meet the needs of the fetus and mother. One of the most common health problems in developing countries is malnutrition among pregnant women. One of the efforts to be made is to improve the nutritional status of pregnant women by providing local food-based snacks, namelysnack peanbars.Research Methods: In this study, experiments were conducted using a completely randomized design (CRD), consisting of five treatment levels, by collecting data on organoleptic properties, data on nutrient values, and data on acceptability. Organoleptic quality was analyzed by hedonic test while the nutrient content (moisture content, ash content, protein content, fat content, and carbohydrate content) was tested in the laboratory Research Result: The results showed that adding peanuts significantly affected aroma and texture (p<0.05). The selected products are formulationsSnack Peanbars t4 (42 g peanuts) with nutritional content per 100 grams with Energy 407.8 kcal, protein 8.90 grams, fat 12.40 grams, carbohydrates 65.15 grams, water content 13.07 grams, ash content 0.47 grams. While acceptanceSnack Peanbars in pregnant women, namely 90% good acceptance and 10% poor acceptance. Conclusion: The addition of 75% peanuts (42 g) had a significant effect on the texture and aroma parameters (p<0.05), while the color and taste parameters had no significant impact (p>0.05). Snack Peanbars per 100 g contain an energy of 407 kcal, protein 8.9 g, fat 12.4 g, and carbohydrates 65.15 g—acceptability results peanbars in pregnant women with good acceptance of 90% and less acceptance of 10%.
PEMBERIAN DUKUNGAN KELUARGA DAN KADER TERHADAP PENURUNAN KECEMASAN IBU HAMIL RESIKO TINGGI DALAM MENGHADAPI PERSALINAN
Authors: Rahmawati Devi , Irmayani Irmayani , Sopiatun Rita 
Published: October 2023

Kehamilan berisiko tinggi dikaitkan dengan lebih banyak kecemasan dan depresi yang akan memperberat resiko komplikasi pada ibu dan bayinya, Pemberian dukungan sosial akan dapat menekan kecemasan dalam menghadapi persalinan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian dukungan keluarga dan kader terhadap penurunan tingkat kecemasan ibu hamil resiko tinggi dalam menghadapi persalinan diwilayah kerja Puskesmas Karang Pule tahun 2020. Desain penelitian yang digunakan adalah quasi-eksperimen dalam bentuk Two group pretest-posttest without control group, penelitian ini dilakukan pada bulan Februari-Maret 2020. Populasi dalam penelitian ini Ibu hamil resiko tinggi di wilayah kerja Puskesmas Karang Pule, sampel penelitian yaitu 36 ibu hamil resti yang memiliki kecemasan dalam menghadapi persalinan, data yang digunakan data primer dan sekunder. Hasil uji statistic dengan Uji wilxocon didapatkan hasil p =0,000 < α = 0,05, maka ada pengaruh dukungan keluarga dan kader terhadap kecemasan ibu hamil resti dalam menghadapi persalinan, dan dilakukan uji Levin didapatkan hasil 3.5 kali artinya dukungan keluarga 3.5 kali lebih efektif dalam menurunkan kecemasan ibu hamil resti dalam menghadapi persalinan, dibandingkan dukungan kader. Dukungan keluarga 3.5 kali lebih efektif dalam menurunkan kecemasan pada ibu hamil resiko tinggi dalam menghadapi persalinan.
PENGARUH EDUKASI DENGAN MEDIA VIDEO TERHADAP PENGETAHUAN DAN PERILAKU REMAJA UNTUK MENCEGAH KEPUTIHAN
Authors: Suwanti Suwanti , Julyartha Yesi Patria , Najahah Imtihanatun 
Published: October 2023

Di Indonesia tahun 2015 sebanyak 987.012.145 jiwa sebesar 90.000 wanita berpotensi mengalami keputihan dan tahun 2016 sebanyak 999.156.124 jiwa sebesar 98.000 mengalami keputihan. Negara Indonesia adalah daerah yang beriklim tropis, sehingga jamur mudah tumbuh dan berkembang yang mengakibatkan banyaknya kasus keputihan pada perempuan Indonesia.Cara mencegah keputihan adalah memberikan pendidikan kesehatan melalui media. Media yang digunakan pada penelitian ini adalah media video.Tujuan Penelitian untuk mengetahui pengaruh edukasi dengan media video terhadap pengetahuan dan perilaku remaja untuk mencegah keputihan. Penelitian ini menggunakan jenis rancangan penelitian Pre Eksperimental menggunakan one group pretest-posttest design. Populasi berjumlah 72 remaja. Sampel penelitian 35 remaja. Analisis data menggunakan Uji Wilcoxon. Berdasarkan hasil penelitian didapatkan pretest rata-rata pengetahuan sebanyak 58,11, pada posttest meningkat menjadi 75,63. Pretest rata-rata perilaku 53,20, pada posttest meningkat menjadi 67,97.Kesimpulan: Didapatkan hasil analisis pengetahuan dan perilaku remaja pvalue=0,000 (<0,05), yang artinya hipotesis diterima sehingga dinyatakan ada pengaruh edukasi dengan media video terhadap pengetahuan dan perilaku remaja untuk mencegah keputihan.
PENGARUH KONSELING MELALUI LAYANAN HOMECARE PADA IBU HAMIL TERHADAP PENGETAHUAN DAN SIKAP IBU HAMIL TENTANG KB AKDR
Authors: Saudia Baiq Eka Putri , Rusmiati Baiq , Sri Wahyuni I Gusti Ayu Putu 
Published: October 2023

Latar Belakang : Di Indonesia saat ini jumlah penduduk dan laju pertumbuhan semakin meningkat. Berdasarkan data badan pusat statistik jumlah penduduk Indonesia tahun 2016 yaitu sebesar 252 juta orang dengan tingkat laju penduduk 1,3 % pertahun atau setiap tahun ada tambahan 3 juta orang. Dalam jangka panjang Indonesia berpotensi mengalami ledakan penduduk. Untuk mencegah ledakan penduduk tersebut pemerintah Indonesia mengadakan program Keluarga Berencana (KB). Berdasarkan data yang diperoleh dari Dinas Kesehatan Kabupaten Lombok Tengah tahun 2019, jumlah akseptor KB IUD masih sangat rendah. didapatkan masih banyak ibu-ibu hamil yang masih percaya mitos mengenai KB AKDR, sehingga perlu dilakukan pemberian konseling mengenai KB AKDR. Agar pemberian konseling lebih mudah diterima, maka peneliti memilih melakukan melalui layanan homecare, sehingga ibu lebih terbuka dan lebih nyaman berdiskusi dengan keluarganya. Tujuan : Apakah ada pengaruh konseling melalui layanan homecare pada ibu hamil terhadap pengetahuan dan sikap ibu hamil tentang KB AKDR di wilayah kerja Puskesmas Batunyala tahun 2020. Metode Penelitian : Desain penelitian ini menggunakan jenis rancangan penelitian Pre Eksperimental dengan menggunakan metode Pretest-Posttest. Penelitian di laksanakan di Wilayah Kerja Puskesmas Batunyale.Teknik sampling yang digunakan adalah sample random sampling dengan jumlah 30 Ibu Hamil. Pengumpulan data primer dilakukan dengan menggunakan lembar kuisioner berupa pre-test dan post-test tentang pengetahun dan sikap Ibu hamil mengenai KB AKDR. Hasil : Hasil uji statistik didapatkan nilai rata-rata pengetahuan dan sikap ibu hamil mengenai KB AKDR dengan analisis Uji Wilcoxon test didapatkan nilai p = 0,000 < α = 0,05 yang berarti bahwa terdapat pengaruh konseling melalui layanan homecare pada ibu hamil terhadap pengetahuan dan sikap ibu hamil tentang KB AKDR di wilayah kerja Puskesmas Batunyala tahun 2020. Kesimpulan : Terdapat pengaruh konseling melalui layanan homecare pada ibu hamil terhadap pengetahuan dan sikap ibu hamil tentang KB AKDR.
Effect of growth hormone administration on ameliorating pregnancy outcome in women with advanced maternal age and exploration of its optimized utilization
Authors: Feng Qihui , Wang Yanbin , Han Hongjing , Shen Huan 
Published: October 2023

BackgroundAge-related fertility decay is a great challenge for clinicians. Growth hormone (GH) supplementation has been studied as an adjuvant since late 1980s. However, it has not come to a consensus on the GH administration due to the ambiguous efficacy among studies with different enrolled population and dosage regime.MethodsA self-controlled retrospective study was conducted on women with advanced maternal age who underwent at least a previous cycle without GH (GH−) and a subsequent cycle with GH co-treatment (GH+). The ovarian stimulation parameters and outcomes were compared between the two cycles and logistical analysis was applied to further explore the association between GH administration protocol as well as other clinical parameters and cumulative live birth in GH+cycle.ResultsA total of 150 women aged 35-43 were included. The number of oocytes retrieved, MII oocytes, 2PNs, transferrable embryos and good-quality embryos in GH+ significantly increased (p &lt; 0.001). The proportion of cycles with no transferrable embryos was significantly reduced in GH+ cycle compared with previous GH− cycle (3 vs. 32; p &lt; 0.001). GH co-treatment cycles showed significantly higher clinical pregnancy rates (43.75% vs. 6.06%; 38.35% vs. 12.04%, p &lt; 0.001), live birth rates (29.17% vs. 0; 27.07% vs. 0, p &lt; 0.001) in both fresh and frozen-thawed embryo transfer cycle. Cumulative live birth rate of the GH+ cycle reached 33.33%. Use of GH prior to Gn stimulation and lasting until the hCG day seemed to achieve a higher successful live birth rate (OR 2.312, 95%CI 1.074-5.163, p=0.032).ConclusionGH supplementation could ameliorate pregnancy outcome in women with advanced maternal age. Dosage regimen of long-term pretreatment prior to Gn stimulation (4 IU every other day) and 4 IU per day until hCG day may of greater efficacy compared with concurrent administration with Gn. Additionally, it’s worthy of exploring whether an individualized dosage regimen based on the IGF or IGFBP level of patient would be more reasonable and effective. More well-designed prospective trials with large sample size and fundamental experiments on the mechanism are required to testify findings above.
Potential contribution of the gut microbiota to the development of portal vein thrombosis in liver cirrhosis
Authors: Huang Xin-yu , Zhang Ying-hui , Yi Shi-yu , Lei Lei , Ma Tao , Huang Rui , Yang Lan , Li Zhen-mao , Zhang Di 
Published: October 2023

BackgroundPortal vein thrombosis (PVT) is a serious complication of liver cirrhosis (LC) and is closely related to gut homeostasis. The study aimed to investigate the composition of gut microbiota and its putative role in PVT development in LC.Methods33 patients with LC admitted between January 2022 and December 2022 were enrolled in this study. Based on imaging findings, they were categorized into LC without PVT (n = 21) and LC with PVT (n = 12) groups. Fecal samples were collected from each participant and underwent 16S rDNA sequencing.ResultsD-Dimer and platelet elevations were the main clinical features of LC with PVT. The alpha and beta diversity of the gut microbiota in LC with PVT group was found to be significantly higher compared to the control group. The structure of the gut microbiota was significantly different between the two groups. Based on LEfSe data, the genera Akkermansia, Eubacterium hallii group, Fusicatenibacter, and Anaerostipes were enriched in the LC with PVT, while Enterococcus, Weissella, Bacteroides, and Subdoligranulum were enriched in those of the LC subjects. Changes in microbiota structure result in significant differences in gut microbiota metabolism between the two groups. Altered levels of the microbiota genera were shown to be correlated with coagulation factor parameters. In animal experiments, the addition of Bacteroides reversed the CCl4-induced PVT.ConclusionLiver cirrhosis with PVT led to a disorder in the gut microbiota, which was characterized by an increase in pathogenic bacteria and a decrease in beneficial bacteria. Furthermore, modulating the gut microbiota, especially Bacteroides, may be a promising therapeutic approach to reduce the progression of PVT in LC.
Selective head cooling in the acute phase of concussive injury: a neuroimaging study
Authors: Walter Alexa E. , Bai Xiaoxiao , Wilkes James , Neuberger Thomas , Sebastianelli Wayne , Slobounov Semyon M. 
Published: October 2023

IntroductionNeurovascular decoupling is a common consequence after brain injuries like sports-related concussion. Failure to appropriately match cerebral blood flow (CBF) with increases in metabolic demands of the brain can lead to alterations in neurological function and symptom presentation. Therapeutic hypothermia has been used in medicine for neuroprotection and has been shown to improve outcome. This study aimed to examine the real time effect of selective head cooling on healthy controls and concussed athletes via magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) measures.Methods24 participants (12 controls; 12 concussed) underwent study procedures including the Post-Concussion Symptom Severity (PCSS) Rating Form and an MRI cooling protocol (pre-cooling (T1 MPRAGE, ASL, single volume spectroscopy (SVS)); during cooling (ASL, SVS)).ResultsResults showed general decreases in brain temperature as a function of time for both groups. Repeated measures ANOVA showed a significant main effect of time (F = 7.94, p &lt; 0.001) and group (F = 22.21, p &lt; 0.001) on temperature, but no significant interaction of group and time (F = 1.36, p = 0.237). CBF assessed via ASL was non-significantly lower in concussed individuals at pre-cooling and generalized linear mixed model analyses demonstrated a significant main effect of time for the occipital left ROI (F = 11.29, p = 0.002) and occipital right ROI (F = 13.39, p = 0.001). There was no relationship between any MRI metric and PCSS symptom burden.DiscussionThese findings suggest the feasibility of MRS thermometry to monitor alterations of brain temperature in concussed athletes and that metabolic responses in response to cooling after concussion may differ from controls.
The ability of the geriatric nutritional risk index to predict the risk of heart diseases in Korean adults: a Korean Genome and Epidemiology Study cohort
Authors: Park Ju Young , Bu So Young 
Published: October 2023

IntroductionThe predictive ability of nutritional risk index on cardiovascular outcomes in middle-aged and non-hospitalized adults has not yet been reported. This study investigated whether the Geriatric Nutritional Risk Index (GNRI), an index for assessing the risk of developing malnutrition, could predict heart disease in middle-aged Korean adults.MethodsThe cohort used in this study consisted of 3,783 participants selected from 10,030 Korean adults who participated in the Ansan-Ansung cohort study as part of the Korean Genome and Epidemiology Study. The GNRI was determined based on serum albumin level, proportion of current weight, and ideal body weight. Participants were then divided into two groups: GNRI ≤98 and &gt; 98, which corresponded to the risk of malnutrition and normal, respectively. The major outcome of this study was coronary artery disease (CAD) or congestive heart failure (CHF) during a 15-year-follow period.ResultsDuring the follow-up period spanning 2004–2018, 136 events of heart disease occurred. Using a Kaplan–Meier analysis, event-free rates were found to be associated with 90.5% on a GNRI ≤98 and 96.6% on a GNRI &gt;98 (p &lt; 0.0009). GNRI ≤98 showed a 3.2-fold (hazard ratio, 3.22; 95% credit interval, 1.49–6.96; p = 0.0029) increase in the incidence of heart disease, including CAD or CHF, compared with GNRI &gt;98, after controlling for potential confounders.ConclusionMalnutrition risk confers a significantly increased risk for heart disease in middle-aged Koreans. Further studies with larger cohorts are needed to verify the efficacy of the GNRI in predicting disease risk in adults with pre-disease.
THE USAGE OF AUGMENTEDCLASS APPLICATION FOR GRAPHIC COMPETENCE DEVELOPMENT OF STUDENTS OF THE 5th-7th GRADES IN THE PROCESS OF CREATING AUGMENTED REALITY PROJECTS
Authors: Poliakov S. , Hrytsenko L. 
Published: October 2023

The article examines the usage of the AugmentedClass application for graphic competence development of students of the 5th-7th grades while creating augmented reality projects. The application’s main functions and interface are described. Methods and techniques that contribute to students’ graphic skills development are presented as well. The advantages of using augmented reality technology in the educational process are considered, in particular, increasing students’ interest in learning and stimulating their creativity. The need to integrate the AugmentedClass application into the educational process is emphasized, which will improve the quality of education and provide active and exciting educational activities for students of the 5th-7th grades. Attention is focused on the fact that the main aspects of graphic competence development are interest, creativity, and skills in using graphic tools, which can be successfully developed with the help of the AugmentedClass application.
It has been found that the usage of augmented reality in the field of education provides students with a significant number of advantages: augmented reality stimulates students’ interest in educational material thanks to interactive content and expands the educational process by providing new competencies and innovative forms of working with the audience, gamification, competitive elements, and cognitive stimuli used in augmented reality activate and motivate students to more independent educational and cognitive activities. Also, the usage of innovative educational tasks, including augmented reality, helps to stimulate students’ educational activity and makes the learning process more exciting and attractive, as well as the usage of augmented reality promotes students’ personal quality development, which is of particular importance for Ukrainian general secondary education institutions, helping to increase their self-esteem and positive attitude to learning.
ELEMENTARY SCHOOL STUDENTS’ GRAPHIC COMPETENCE FORMATION USING COMPUTER-ORIENTED TEACHING TOOLS
Authors: Kilderov D. , Boiko V. 
Published: October 2023

The article deals with the topical issue of elementary school students’ graphic competence formation using computer-oriented teaching tools. In today’s digital world, where information is presented in various graphic formats, graphic competence is an essential skill for elementary school students. Graphic competence involves the ability to understand, create, and analyze graphics using computer technology. The main aspects of elementary school students’ graphic competence formation through the usage of computer-oriented teaching tools have been determined. Modern approaches to teaching graphic skills and their influence on the educational process are considered. The practical aspects of the implementation of computer-oriented teaching tools for improving students’ graphic competence are highlighted. It is noted that graphic training during primary school education is crucial for students’ future education, as it lays the foundations for the basics of graphic literacy. However, one of the main shortcomings in the educational process related to the study of graphic disciplines is the lack of unity in teaching methods between secondary and higher schools.
It is considered that computer-based teaching tools represent a wide range of technological tools and programs designed to facilitate and facilitate learning through the usage of computers. These tools can be successfully implemented in the educational process at all levels, from primary school to higher education. They cover a wide range of technologies and methodologies, including learning software, interactive exercises, video tutorials, virtual reality, and more. It is determined that augmented reality technology opens up new opportunities for improving elementary school students’ graphic competence. It facilitates the visualization of educational material, ensures the active participation of students in learning, and promotes the graphic content creation. The usage of AR can be a significant step in improving the quality of education and developing the graphic skills of a new generation.