bluuebunny/crossref_metadata_2025_split huggingface dataset:
New methods for detection of early loss of rapid flicker, spatial vision, and chromatic sensitivity in glaucoma
Authors: Hafeez Aiman , Barbur John L. , Ctori Irene , Binns Alison , Wong Sui , Lim Sheng 
Published: January 2024

Purpose: To examine whether ocular hypertension and early glaucoma cause measurable changes in spatial vision, rapid flicker sensitivity and red/green and yellow/blue colour vision.Methods: We examined subjects aged 40 to 78 years with ocular hypertension (OHT), primary open angle glaucoma (POAG), normal tension glaucoma (NTG), and age matched controls. Monocular best corrected visual acuity (BCVA) was tested using EDTRS charts.VA and Functional Contrast Sensitivity (FCS) with Landolt ring stimuli of both positive and negative contrast were also measured monocularly with the Acuity‐Plus test. Red/green (RG) and yellow/blue (YB) colour thresholds were measured with the Colour Assessment and Diagnostics (CAD) test. Photopic (cone‐enhanced) and mesopic (rod‐enhanced) rapid flicker thresholds were measured at the fovea (0°) and at an eccentricity of 5° in each of the four quadrants using the Flicker‐Plus test. All subjects had their visual fields measured using the Humphrey visual field analyser (24–2 SITA standard protocol). Peripapillary retinal nerve fibre layer thickness (pRNFLT) and macular retinal layer thicknesses were measured using the Heidelberg Spectralis OCT.Results: The mean, logMAR BCVA for OHT patients was 0.00 and for POAG and NTG patients was −0.10 and 0.10, respectively. For control participants, mean logMAR BCVA was 0.00. Mean pRNFL thickness was significantly reduced for glaucoma patients (59.5 ± 7.7 μm) as compared to control subjects (94.6 ± 5.13 μm) and OHT patients (115.5 ± 3.5 μm). POAG and NTG patients showed significantly higher colour thresholds (mean red/green threshold 4.97, blue/yellow 5.28 CAD units) compared to control subjects (mean red/green threshold 2.07, blue/yellow 1.62 CAD units). One OHT patient showed acquired loss of blue/yellow colour vision (3.23 CAD units), with normal VA. The Acuity‐Plus test which employs briefly presented stimuli, also revealed significant loss of VA (3.78 and 3.64 min of arc) and FCS (141.32% and 100%) in an NTG patient, with results outside normal limits for both positive and negative contrast, respectively. Central FCS was higher and outside the normal age limits for POAG patients (73.41% and 89.27%) as compared to age matched controls (61.27% and 33.63%). OHT patients, on the other hand, produced FCS thresholds within normal limits. Flicker modulation thresholds were higher for both rod and cone enhanced stimulus conditions in glaucoma and OHT patients, when compared to control subjects.Conclusion: The results reveal non‐uniform, losses that can affect selectively each of the visual attributes examined in this study. These preliminary findings suggest that in addition to VA and FCS tests, colour vision and rapid flicker sensitivity should also be examined in patients with optic nerve pathologies like glaucoma.
Cost‐effectiveness simulation of AI screening for DR in Japan
Authors: Kawasaki Ryo , Akune Yoko , Hiratsuka Yoshimune , Yamada Masakazu 
Published: January 2024

Aims: We investigated the efficacy of AI‐based screenings in preventing blindness, specifically assessing cost‐effectiveness when two further detection opportunities are incorporated: “DR screening during national health checkups” and “DR screening during diabetes clinic visits at a physician's office”, or a combination of the two. We also examined potential additional costs associated with AI screening under various conditions.Methods: We employed a Markov Model in this simulation study. We constructed the modelling of diabetes detection, treatment, and retinopathy treatment based on transition probabilities derived from epidemiological and clinical studies. These covered incidence and progression rates of diabetes and diabetic retinopathy, treatment options and their efficacy, and visual prognosis. The age range for the model was set at 40–90 years with a 1‐year cycle, assuming a population of 500 000 individuals with a discount rate of 2%. Simulations were conducted using TreeAge. Costs were calculated using the direct costs of general health examinations and insurance treatments. We assumed diabetic retinopathy would result in a consistent visual acuity following detection, progression, and treatment, providing utility values based on the severity of DR.Results: DR screening via AI in health check‐up programs proved not to be cost‐effective, as it led to a 0.9% increase in cumulative blindness and the ICERs were dominated. The addition of an annual AI screening at physicians' clinics, with referrals to ophthalmology based on the results, resulted in an ICER of 8192751JPY/QALY, which was not cost‐effective. However, assuming that 75% of patients received AI screening during medical examinations and that 75% of these underwent ophthalmological examinations per the results, AI screening proved to be dominant and cost‐effective, reducing the cumulative number of blindness by 2.8%.Conclusions: Even though automated AI diagnosis of DR is becoming a reality, our findings suggest that merely introducing AI screening in health checkups and physicians' clinics in Japan will not be cost‐effective. However, cost‐effectiveness can be improved by increasing the rate of screening and the follow‐up rate of ophthalmological examinations. If this is achieved, there might also be a possibility of incurring additional costs due to AI screening. Our study underlines the importance of a seamless link from diabetes detection to ophthalmologic care for successful DR screening with AI systems.
Update on the range of visual electrophysiology tests and heir application with clinical examples
Authors: Robson Anthony G. 
Published: January 2024

The International Society for clinical electrophysiology of vision (ISCEV) publishes open‐access standards and guidelines for routine electrophysiological tests of the visual system in order to optimize diagnostic value, to promote consistency and to allow meaningful inter‐laboratory comparisons. The ISCEV also publishes extended protocols with the aim of promoting convergence of methods that are not yet standardized, for tests that are widely used but often performed as an addition to the minimum ISCEV standard procedures (see www.ISCEV.org for all publications).This talk will outline the main ISCEV standard methods including the full‐field electroretinogram (ERG), pattern ERG (PERG) and multifocal ERG (mfERG). Several extended full‐field ERG protocols will also be highlighted, including the dark‐adapted (DA) red flash ERG, photopic On–Off ERG and S‐cone ERG. The use of these methods in the clinic will be illustrated in cases of inherited and acquired retinal disorders, to show how the extended protocols complement standard techniques, to aid diagnosis and patient management and to probe and detail retinal function phenotypes.The Standard full‐field ERG is recorded under dark‐adapted (DA) and light‐adapted (LA) conditions and provides a measure of generalized rod and cone system function at the level of the outer and inner retina, with minimal contribution from the macula. The mfERG assesses cone system function across the posterior pole and the PERG assesses macular and macular retinal ganglion cell function.The DA red flash ERG is an extended protocol that provides a measure of generalized dark‐adapted retinal function, with the advantage of having both a cone system x‐wave and a rod system b‐wave within the same waveform. This enables the relative involvement of rod and cone systems to be assessed simultaneously and can help determine the origins of severely attenuated standard DA strong flash ERGs. The DA red flash ERG is also useful for assessing cone system function in photophobic patients, and in patients with variable ability to comply with longer ERG protocols. The photopic On–Off ERG is a response to an extended light stimulus (duration 150 or 200 ms) and is used to assess generalized cone system function of both the On and Off retinal pathways, useful when there is a locus of dysfunction that is post‐phototransduction or post‐receptoral, when On and Off retinal systems may be similarly, selectively or specifically affected e.g., in different forms of congenital stationary night blindness (CSNB) or in forms of toxic retinopathy. The S‐cone ERG (short‐wavelength or “blue” flash ERG) is used to probe the function of the S‐cone retinal pathway, and can aid diagnosis and characterization in a variety of retinal dystrophies and disorders e.g., distinguishing between achromatopsia and S‐cone monochromacy.
Higher end‐of‐treatment HBsAg levels is associated with later onset but not severe relapse in HBeAg‐negative chronic hepatitis B patients stopping antivirals
Authors: Liu Yen‐Chun , Jeng Wen‐Juei , Peng Chien‐Wei , Chien Rong‐Nan , Liaw Yun‐Fan 
Published: January 2024

SummaryBackgroundQuantitative hepatitis B surface antigen (qHBsAg) level at end‐of‐treatment (EOT) predict clinical relapse (CR) after nucleos(t)ide analogues (Nuc) in chronic hepatitis B(CHB) patients. It is unclear if higher EOT qHBsAg leads to earlier onset or more severe off‐Nuc CR.AimThis large cohort study investigates the association between EOT qHBsAg and CR onset/severity.MethodsThis study enrolled HBeAg‐negative CHB patients who had achieved undetectable HBV DNA for over 1 year after receiving Nuc therapy before discontinuation. The EOT qHBsAg level was categorised into three groups: <100, 100–999, ≥1000 IU/mL. The study assessed the predictability of qHBsAg levels for CR, and analysed and compared the incidence, time to onset and severity of CR among these three groups.ResultsPatients with higher EOT qHBsAg showed a higher incidence of CR (≥1000, 100–999, <100 IU/mL: 73%, 65%, and 38%, p < 0.01) but a later onset of CR (median time to CR: 35, 33 and 27 weeks, p < 0.01). The predictabilities of EOT qHBsAg for CR were greater in patients aged <50‐year‐old or with genotype C than in those aged ≥50‐year‐old or with genotype B. There's no correlation between EOT qHBsAg level and ALT folds at CR (Pearson correlation coefficient: r = −0.03, p = 0.35). EOT qHBsAg was neither a predictor for severe hepatitis flare nor a predictor for hepatic decompensation.ConclusionsPredictability using EOT qHBsAg levels for CR differed in subgroups of age and genotypes. Higher EOT qHBsAg levels correlate with higher incidence but later onset of CR. No correlation between EOT qHBsAg and relapse severity was observed.
Shared decision‐making and social science: A patient perspective
Authors: Ostroff Cheri 
Published: January 2024

AbstractShared decision making (SDM) between doctors and patients has been deemed important when providing care. Yet, it can be difficult to achieve. Specific examples from a patient perspective are integrated with the social science literature to provide an overview of components of SDM including the role of fit, trust, information asymmetry, cognitive decision frames and balancing medical and patient outcomes. Consideration of these issues should facilitate higher quality SDM conversations.
Making depositors greedy and careless: Government safety nets and the degradation of depositor discipline
Authors: Phung Giang , Troege Michael 
Published: January 2024

AbstractIn emerging countries, deposits play an important role in banks' total funding; hence, depositor discipline may significantly impact banking performance and financial system stability. This paper investigates depositor discipline before and after Vietnam's 2008–2011 banking crisis when depositors had little experience regarding bank bailouts and the amount of deposit insurance was limited to a low cap. The study points out that before the crisis, the level of deposit financing in banks depended on both the interest rates offered and on measures of banks' risk‐taking. After the crisis, given that the Vietnamese government prevented all bank failures to ensure economic, political, and social stability, depositors still react to interest rate changes, but substantially less to risk. This suggests that they have learned that their deposits are safe regardless of the risk the bank is taking.
BCC and Immunocryosurgery scar differentiation through computational resolution‐enhanced OCT images and skin optical attenuation: A proof‐of‐concept study
Authors: Pavlou Eleftherios , Gaitanis Georgios , Bassukas Ioannis D. , Kourkoumelis Nikolaos 
Published: January 2024

AbstractMonitoring medical therapy remains a challenging task across all non‐surgical skin cancer treatment modalities. In addition, confirmation of residual tumours after treatment is essential for the early detection of potential relapses. Optical coherence tomography (OCT), a non‐invasive method for real‐time cross‐sectional imaging of living tissue, is a promising imaging approach for assessing relatively flat, near‐surface skin lesions, such as those that occur in most basal cell carcinomas (BCCs), at the time of diagnosis. However, the skin's inherent property of strong light scattering impedes the implementation of OCT in these cases due to the poor image quality. Furthermore, translating OCT's optical parameters into practical use in routine clinical settings is complicated due to substantial observer subjectivity. In this retrospective pilot study, we developed a workflow based on the upscale of the OCT images resolution using a deep generative adversarial network and the estimation of the skin optical attenuation coefficient. At the site of immunocryosurgery‐treated BCC, the proposed methodology can extract optical parameters and discriminate objectively between tumour foci and scar tissue.
Corporate pollution and reputational exposure
Authors: Chortareas Georgios , Kou Fangyuan , Ventouri Alexia 
Published: January 2024

AbstractWe study the empirical association between corporate pollution and reputational exposure using a sample of 745 U.S. firms from 2007 to 2019 and an ordered probit model. Our results reveal an inverse relationship between chemical emissions and reputational exposure rating, after controlling for various firm attributes. We examine the roles of corporate governance structure and the demographic background of the top management team in the transmission process from polluting chemical emissions to reputation. Further, the negative impact of corporate pollution on reputational exposure rating is much stronger in areas where residents are convinced that climate change is happening. We perform several tests and analyses designed to mitigate endogeneity issues and correct sample bias to ensure the robustness of our findings. Finally, our results suggest that the negative effect is stronger for companies with higher information asymmetry, which indicates the importance of information transparency for firms' credibility.
Digital pathology for reporting histopathology samples, including cancer screening samples – definitive evidence from a multisite study
Authors: Azam Ayesha S , Tsang Yee‐Wah , Thirlwall Jenny , Kimani Peter K , Sah Shatrughan , Gopalakrishnan Kishore , Boyd Clinton , Loughrey Maurice B , Kelly Paul J , Boyle David P , Salto‐Tellez Manuel , Clark David , Ellis Ian O , Ilyas Mohammad , Rakha Emad , Bickers Adam , Roberts Ian S D , Soares Maria F , Neil Desley A H , Takyi Abi , Raveendran Sinthuri , Hero Emily , Evans Harriet , Osman Rania , Fatima Khunsha , Hughes Rhian W , McIntosh Stuart A , Moran Gordon W , Ortiz‐Fernandez‐Sordo Jacobo , Rajpoot Nasir M , Storey Ben , Ahmed Imtiaz , Dunn Janet A , Hiller Louise , Snead David R J 
Published: January 2024

AimsTo conduct a definitive multicentre comparison of digital pathology (DP) with light microscopy (LM) for reporting histopathology slides including breast and bowel cancer screening samples.MethodsA total of 2024 cases (608 breast, 607 GI, 609 skin, 200 renal) were studied, including 207 breast and 250 bowel cancer screening samples. Cases were examined by four pathologists (16 study pathologists across the four speciality groups), using both LM and DP, with the order randomly assigned and 6 weeks between viewings. Reports were compared for clinical management concordance (CMC), meaning identical diagnoses plus differences which do not affect patient management. Percentage CMCs were computed using logistic regression models with crossed random‐effects terms for case and pathologist. The obtained percentage CMCs were referenced to 98.3% calculated from previous studies.ResultsFor all cases LM versus DP comparisons showed the CMC rates were 99.95% [95% confidence interval (CI) = 99.90–99.97] and 98.96 (95% CI = 98.42–99.32) for cancer screening samples. In speciality groups CMC for LM versus DP showed: breast 99.40% (99.06–99.62) overall and 96.27% (94.63–97.43) for cancer screening samples; [gastrointestinal (GI) = 99.96% (99.89–99.99)] overall and 99.93% (99.68–99.98) for bowel cancer screening samples; skin 99.99% (99.92–100.0); renal 99.99% (99.57–100.0). Analysis of clinically significant differences revealed discrepancies in areas where interobserver variability is known to be high, in reads performed with both modalities and without apparent trends to either.ConclusionsComparing LM and DP CMC, overall rates exceed the reference 98.3%, providing compelling evidence that pathologists provide equivalent results for both routine and cancer screening samples irrespective of the modality used.
Microstructure and microwave‐absorbing properties of B4C/C composite powders produced by combustion synthesis with an AC foaming agent
Authors: Zhou Xiaoqian , Ding Donghai , Xiao Guoqing , Mu Yan , Xing Boying , Deng Peilin , Zhang Yanjie 
Published: January 2024

AbstractTo develop microwave‐absorbing properties of dielectric ceramics, B4C/C composite powders were prepared by combustion synthesis with B2O3, polyvinyl alcohol, and Mg as the raw materials in this work. The XRD, Raman, scanning electron microscope with energy‐dispersive spectroscopy, and VNA network analysis carried out the effects of the addition of azodicarbonamide (AC) foaming agent on the phase compositions, microstructure, and dielectric and microwave‐absorbing properties of the products. The results indicated that the addition of an AC foaming agent contributed to the formation of distinct morphologies with a larger specific surface area and uniform distribution of the free carbon in the B4C/C composite powders and improved its graphitization degree, which resulted in the formation of equivalent microcapacitors, enhanced interfacial polarization, improved conductive network, and leading to a low reflection loss (RL) and a broadened effective absorb bandwidth (EAB). Due to the dielectric loss as the dominant loss mechanism, C‐1.5 (1.5 wt.% AC foaming agent addition) exhibits the EAB of 3.02 GHz and the minimum RL (RLmin) of −22.90 dB at the thickness of 2.20 mm.
Sex‐specific differences in telomere length of patients with primary knee osteoarthritis
Authors: Kuszel Lukasz , Trzeciak Tomasz , Begier‐Krasinska Beata , Richter Magdalena , Li Jian , Czarny‐Ratajczak Malwina 
Published: January 2024

AbstractAccelerated telomere shortening is associated with age‐related diseases, including osteoarthritis (OA). We aimed to determine the relative telomere length (TL) in leukocytes and cartilage of patients with primary knee OA and to investigate factors that may affect TL in OA. Relative TL measurements were performed using qPCR in leukocytes of 612 individuals (310 patients with primary knee OA undergoing total knee arthroplasty (TKA) and 302 unaffected controls). We also analysed cartilage in 57 of the 310 OA patients, measuring relative TL in severely affected and less affected (control) cartilage collected from the same knee. Cartilage TLs were compared to leukocyte TLs in all 57 patients. A significant sex‐by‐disease‐status interaction was found in regard to relative TL. Controlling for age, the average difference of leukocyte TL between female OA patients versus female controls was 0.217 units greater than that between male OA patients versus male controls (95% CI; [0.014, 0.421]). Relative TL comparison of severely and less affected cartilage samples from the same joint showed attrition of telomeres corresponding to disease severity (0.345 mean TL difference with 95% CI of [0.151, 0.539]) in the joint. We also noted that both severely and less affected cartilage had shorter telomeres than leukocytes collected from the same patient. Severe and moderate pain in OA patients was associated with shorter TL in leukocytes, but there was no association with depression or smoking in leukocytes and cartilage. Our study indicates that sex is an important factor in OA contributing to leukocyte and cartilage TL and that pain in OA shows an inverse association only with leukocyte TL.
Rifaximin treatment shapes a unique metagenome‐metabolism network in patients with decompensated cirrhosis
Authors: Nie Mei‐Tong , Wang Pei‐Qin , Shi Pei‐Mei , Hong Xia‐Lu , Zhang Xin , Xiang Baoyu , Zhang Menghui , Xie Wei‐Fen 
Published: January 2024

AbstractBackgroundPatients with decompensated cirrhosis face poor prognosis and increased mortality risk. Rifaximin, a non‐absorbable antibiotic, has been shown to have beneficial effects in preventing complications and improving survival in these patients. However, the underlying mechanisms of rifaximin's effects remain unclear.MethodsWe obtained fecal samples from decompensated cirrhotic patients undergoing rifaximin treatment and controls, both at baseline and after 6 months of treatment. Shotgun metagenome sequencing profiled the gut microbiome, and untargeted metabolomics analyzed fecal metabolites. Linear discriminant and partial least squares discrimination analyses were used to identify differing species and metabolites between rifaximin‐treated patients and controls.ResultsForty‐two patients were enrolled and divided into two groups (26 patients in the rifaximin group and 16 patients in the control group). The gut microbiome's beta diversity changed in the rifaximin group but remained unaffected in the control group. We observed 44 species with reduced abundance in the rifaximin group, including Streptococcus_salivarius, Streptococcus_vestibularis, Haemophilus_parainfluenzae, etc. compared to only four in the control group. Additionally, six species were enriched in the rifaximin group, including Eubacterium_sp._CAG:248, Prevotella_sp._CAG:604, etc., and 14 in the control group. Furthermore, rifaximin modulated different microbial functions compared to the control. Seventeen microbiome‐related metabolites were altered due to rifaximin, while six were altered in the control group.ConclusionOur study revealed distinct microbiome‐metabolite networks regulated by rifaximin intervention in patients with decompensated cirrhosis. These findings suggest that targeting these specific metabolites or related bacteria might be a potential therapeutic strategy for decompensated cirrhosis.