bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of gene mutation spectrum and prevention and treatment of lung cancer patients in Qujing, Yunnan Province, China
Authors: Zhou yanji , Chai shiwei , Chen yajuan , Guo pin 
Published: November 2023

Abstract
Objective
To analyze the correlation between driver genes and clinicopathological features of lung cancer patients in Qujing, Yunnan, and evaluate the efficacy of drugs under different lung cancer gene mutations to discover the mutated gene spectrum of lung cancer in this area and contribute to the optimization of targeted therapy for lung cancer patients.
Methods
We collected clinical data from 363 lung cancer patients admitted to the First People's Hospital of Qujing City from 2018 to 2020 as well as their oncogene detection reports. The epidemiological characteristics and influencing factors of lung cancer in Qujing were analyzed.
Results
There were more EGFR, KRAS, and TP53 mutations and non-clinically significant gene mutations in Qujing, and less than 5% mutations in other genes. In addition to the high frequency of exon 19 deletion or exon 21 L858R missense mutations, there were more EGFR-p.Ser768Ile compound mutations in EGFR single gene mutations. KRAS mutations were concentrated in KRAS-p.gly12cys mutations, while TP53 mutations were mostly compound mutations. There were significant differences in the frequency of different gene mutations in male and female patients (P < 0.05). EGFR mutations were dominant in females, while TP53 mutations were dominant in males. Single KRAS gene mutations were not influenced by sex, but its combined mutation was affected by the TP53 gene. The number of male patients was slightly higher than that of female patients. There was a significant difference in gene mutation frequency between patients with or without smoking and drinking history (P < 0.05). Compared with other chemotherapy regimens, AP chemotherapy significantly improved clinical efficacy in the Qujing region.
Conclusions
The correlation between the characteristics of different mutant genes and clinicopathology can provide a basis for the treatment and prognosis of patients with lung cancer in Qujing. Accurate early screening is critical for lung cancer patients with high incidence and no history of smoking or drinking. The AP chemotherapy regimen showed advantages compared with other chemotherapy regimens in the Qujing area.
A Comprehensive Study on Diversity and Land Use of the Bird Species around Eco Park Area, Kolkata, West Bengal
Authors: Rong Abhik , Besra Sumana , Chatterjee Lina , Samanta Tarak , Mazumdar Souvik , Hazra Dipak , Samrat Cs , Roy Arjan Basu 
Published: November 2023

Abstract

In contemporary ecology, conservationists and researchers work to safeguard and maintain the diverse range of life on Earth, with biodiversity protection being a primary focus. Avian species fulfil a vital function within ecosystems, serving as significant indicators for evaluating the condition of habitats and identifying changes in the surrounding environment. The examination of avian species diversity across various habitats is of paramount importance in the understanding of ecological dynamics and the facilitation of conservation efforts. This study investigates the avian diversity and activity patterns across four distinct habitat types, including forestland, marshland, grassland, and water bodies. Through rarefaction analysis and visual representations, these ecosystems show notable differences in terms of species diversity and ecological characteristics. The findings confirm the fundamental importance of forests and wetlands in offering sustenance for diverse biological populations. The examination of clustering provided insight into the resource distribution and niche-occupation strategies used by bird families. The visual representation of bird activity highlights the capacity of avian communities to adapt and use resources and opportunities that are unique to their respective environments. This study underscores the significance of tailoring conservation initiatives to the unique ecological attributes of different habitats, hence promoting the conservation and ethical utilisation of avian species. Gaining insight into these patterns is necessary to make well-informed judgements on conservation initiatives and habitat management.
Observations of co-existing rising and falling tone emissions of electromagnetic Ion cyclotron waves
Authors: OJHA BISWAJIT , Omura Yoshiharu , Singh Satyavir , Lakhina Gurbax 
Published: November 2023

Abstract
We report observations of co-existing rising and falling tone emissions of Electromagnetic Ion Cyclotron (EMIC) waves by THEMIS E spacecraft. The investigation of these fine structures of the EMIC waves is essential from the point of view of understanding the connection between the proton holes and the proton hills in velocity phase-space.

The wave packets of rising and falling tones are tracked by Poynting vector analysis, where we observe that the rising tones are propagating northward and the falling tones are propagating southward. The nonlinear wave growth theory supports our observations. We propose a model where the proton velocity distribution function evolves through the formation of proton holes on the negative side of the distribution function and mirrored resonant protons forming proton hills on the positive side of the distribution function, allowing us to observe the co-existing rising and falling tone EMIC waves.
Non-linear association of low birthweight with risk factors including women’s BMI: Evidence from an international comparison
Authors: Yamane Chisako , Tsutsui Yoshiro 
Published: November 2023

Abstract
Background It is widely known that, in addition to physical characteristics such as parents’ height and weight, social attributes such as parents’ education, income level, and employment status have a significant impact on birthweight. However, these results were obtained using data from individual countries, and there were no country-level comparisons of the factors identified as influencing birthweight.
Methods Using panel data on low-birthweight fertility rates for 143 countries over the period of 2000–2015, we used five factors (women’s body mass index [BMI], real gross domestic product [GDP] per capita, women’s employment status, healthcare level, and adolescent childbearing) in relation to countries’ low-birthweight rates to determine how these factors relate to each country's low-birthweight rate and estimate a fixed-effects model. Considering the possibility that these five factors are non-linear rather than linear, we estimated a quadratic function. We conducted a detailed analysis of women’s BMI and real GDP per capita. Furthermore, we considered the 2008 global financial crisis as an exogenous natural experiment for the low-birthweight rate and conducted a difference-indifferences (DID) analysis to confirm the possibility that the correlation between women’s employment rate and low-birthweight rate is a causal relationship.
Results All five factors were identified as important risk factors. Of the five, all but adolescent childbearing were found to have a non-linear rather than a monotonous linear relationship with low birthweight. The low-birthweight rate improved sharply with improvement in women's average BMI below 28. Furthermore, the results of the DID analysis suggest a causal relationship between women's employment and low-birthweight rates.
Conclusions These results provide a useful policy tool for achieving the goal of the 65th World Health Assembly to “reduce the incidence of low birthweight.” In particular, improvements in women’s average BMI, real GDP per capita, and women’s employment rates in low-income countries are expected to reduce the incidence of low birthweight.
Application of Failure Mode and Effect Analysis to reduce errors in medication administration in pediatric intensive care units: A quality improvement report
Authors: Hooshmand Elaheh , Ghane Hasan , Ghasemian Amir , Ebrahimipour Hossein , Dadpour Bita , Vafaeenajar Ali 
Published: November 2023

Abstract
Background:
prevention of medication errors in pediatric intensive care due to age and physiological condition of the patient it is very important .This study aims to identify, evaluate, and analyze potential errors in the process of drug prescription and administration in pediatric intensive care unit of Imam Reza teaching hospital in Mashhad using systematic approach of FMEA.
Methods:
In this mixed method descriptive cross-sectional study, modes and effects of error were identified and analyzed using FMEA. This study was conducted in 10 steps. To determine potential failure modes and effects of errors team brainstorming tool is used and Factors affecting modes of error were identified using cause and effect graph (fishbone) and brainstorming method. Determined improvement strategies through interviews with team members and taking into account the requirements of the proposed risk priority number again for each of interventions were calculated.
Results:
Identification of drug prescription and administration in intensive care unit resulted in identifying seven activities and 29 sub-processes in total drug prescription and administration processes. 68 error modes were identified of these 27 were detected as hight risk failure mode (40 ≤ RPN). Interventions that were designed to correct these errors reduced the amount of up to 50%.
conclusion:
FMEA showed high potentials in identifying, evaluating, prioritizing and analyzing errors in drug prescription and administration processes in pediatric intensive care unit.
Analysis of 91 cases of nasal endoscopic surgery for nasal and ocular- related diseases
Authors: Qi Hui , Tu Xiang , Xiong Qinglan , Liu Guiqin , Sun Yueqi , Xiong Cheng , Fan Yunping , OuYang Ming 
Published: November 2023

Abstract
The efficacy of nasal endoscopy for nasal and ocular-related diseases remains largely elusive. We retrospectively analyzed the data of 91 patients (158 eyes) with nasal and ocular-related diseases from Feb 2017 to April 2022 were used to analyze the effects of different operations. We demonstrated that the 13 patients (13 eyes) with traumatic optic neuropathy, nine (69.2%) demonstrated improved visual acuity post-operatively. Of the 65 patients (130 eyes) with thyroid-related ophthalmopathy, 120 eyes (92.3%) have less proptosis post-operatively, whereas 10 eyes showed no changes. One case noted worse visual acuity post-operatively, and 20 eyes noted new-onset diplopia. In eight cases (8 eyes) with retroorbital space-occupying lesions, five patients (62.5%) noted visual acuity and visual field improvements post-operatively. We propose that although nasal endoscopic surgery has some limitations in the orbit, it is a safe, effective, and minimally invasive option for nasal and ocular-related conditions. Close collaboration between ophthalmologists and rhinologists is important.
Temperature-adaptive Ni3Al-based self-lubricating alloys
Authors: Chen Jie , Zheng Min , Zhu Zongxiao , Chen Jiao , Cheng Jun , Zhu Shengyu , Yang Jun 
Published: November 2023

Abstract
Temperature-adaptive Ni3Al-based self-lubricating alloys prepared by powder metallurgy were investigated and evaluated over a wide temperature range. Ni3Al-Ag-V alloys exhibit excellent self-lubricating properties and wear resistance over a wide temperature range, especially for the Ni3Al-20 wt%Ag-5 wt%V alloy with friction coefficients as low as 0.26 and 0.23 at room temperature and 900°C, respectively, and wear rates as low as 5 × 10− 6 mm3/Nm and 4 × 10− 5 mm3/Nm in turn. It is proposed for a lubrication mechanism that temperature-adapted lubrication is provided by the soft metal Ag at low temperatures and AgVO3 and Ag3VO4 produced by tribo-chemical reactions at high temperatures.
Relationship between Visual Fatigue and Tear Film Stability in Smartphone Use: A objective validation study
Authors: Watanabe Maki , Hirota Masakazu , Takigawa Ryusei , Kato Kanako , Ikeda Yuka 
Published: November 2023

Abstract
Background:
To investigate whether tear film instability induces visual fatigue, we used the binocular fusion maintenance (BFM) test and non-invasive tear film break-up time (NI-BUT).
Methods:
Eleven young adult volunteers (age [mean ± standard deviation], 20.7 ± 1.4 years) participated in this study. BFM was assessed by measuring the transmittance of liquid crystals placed in front of the subject’s non-dominant eye when binocular fusion was broken, and non-dominant eye was shifted to heterophoric. The NI-BUT was determined using the distortion of the Meyer ring. The volunteers were administered the BFM, NI-BUT, and subjective symptom questionnaire before and after a 30-minute visual task.
Results:
BFM (pre vs. post: 0.95 ± 0.09 vs. 0.75 ± 0.16) was significantly lower in the post-visual task than in the pre-visual task (P = 0.012). NI-BUT (9.12 ± 1.00 s vs. 5.69 ± 3.11 s) was significantly shorter in the post-visual task than in the pre-visual task (P = 0.011). Total subjective eye symptom (2.91 ± 0.79 vs. 5.45 ± 2.02) was significantly greater in the post-visual task than in the pre-visual task (P = 0.012). The change in BFM (− 0.20 ± 0.18) was significantly and positively correlated with the change in NI-BUT (− 3.43 ± 3.19) (R2 = 0.385, P = 0.042) and was significantly and negatively correlated with the change in total subjective eye symptom score (2.54 ± 2.23) (R2 = 0.470, P = 0.020).
Conclusion:
The findings suggest that tear film instability induces visual fatigue.
Trial registration:
UMIN000039665, 03/02, 2020.
Complex Regional Pain Syndrome: Diagnostic Challenges and Favorable Response to Prednisolone
Authors: Olomi Jimmy , Munthali Victoria 
Published: November 2023

Abstract
Complex regional pain syndrome (CRPS), characterized by severe and disproportionate pain, is a rare and debilitating condition. Due to its rarity, evidence-based treatment guidelines remain limited, creating a challenge for clinicians. We present the case of a 20-year-old female with CRPS type 1 of the right hand. Her pain, initially triggered by a minor trauma, had persisted for three months. The patient demonstrated severe pain, swelling, hyperesthesia, and restricted range of motion. Despite multiple hospital visits, her symptoms did not improve until she was diagnosed with CRPS and treated with oral prednisolone. A dosage of 40 mg daily led to a dramatic response within 10 days. Our report emphasizes the importance of recognizing CRPS and highlights the potential of prednisolone as a treatment option, particularly in resource-limited settings, where more specialized interventions may be unavailable. Further research is essential to establish a stronger evidence base for the use of steroids in CRPS management.
A Preliminar Study of the Avifauna Composition of Four Parks in Salto, São Paulo, Brasil
Authors: Constantino Daniel Josué , Maia Bárbara Maria Cerqueira , Lima Vinícius Emanuel Brito 
Published: November 2023

Abstract
The birdlife of a given region plays several ecological roles, such as plant pollination, seed dispersion pest control, maintenance of gene flow, in addition to attracting tourists to birdwatching. Therefore, knowledge about this biota is related to its importance within ecosystems and to quantifying the effects of human intervention on their habitats. The municipality of Salto, located in the southeast of São Paulo/Brazil, is a mutualistic transition zone that comprises areas of three brazilians biomes. Furthermore, the city has a large presence of riparian forest on the banks of the Tietê River, and for this reason, it is one of the 70 cities in the state considered touristic resorts, standing out for its natural landscape and attracting ecotourism. To characterize the endemic and migratory native bird communities in Salto, the present work was carried out in four diferent preserved parks, from March/2021 to March/2023. The analysis was carried out based on field observation and survey of photographic records on the WikiAves platform, using qualitative criteria, in which 340 species of wild birds were cataloged in the area. This is the first study of birdlife characterization in the region, whose main objective was to generate data and demonstrate ecological dynamics between main fragments, to monitor seasonal movement of avifauna and also provide subsidies for environmental enrichment in the area. Through this study, it is also possible to plan new strategies for conservation, environmental education and sustainable tourism in the municipality.
Reward prediction errors drive reinforcement learning and episodic memories: gender differences in individuals with methamphetamine use disorder
Authors: Liu Yuqing , Wang Die , Wang Leping , Yu Chenghao , Wang SongSong , Huang Fang , Wang Tiancheng , Jin Shengyi , Zhou Qiang 
Published: November 2023

Abstract
Background
Individuals with methamphetamine (MA) use disorder have impaired executive functioning with gender differences, which may be related to the reward prediction errors (RPEs) that drive reinforcement learning and episodic memories, as RPE signaling is impaired in these individuals.
Objectives
We examined whether the driving effects of RPE on reinforcement learning and episodic memories are impaired in individuals with MA use disorder and how differ between women and men.
Methods
A total of 82 individuals with MA use disorder in abstinent (MA group: 47.6% female) and 86 non-users (control group: 47.7% female) were recruited and required to learn the mean value of a reward in a learning situation. Reward prediction error was manipulated by giving different monetary reward feedback after each reward prediction.
Results
Compared to non-users, the MA group had lower learning rate for rewards and recognition-memory accuracy for items. The effect of reward prediction error showed a dissociable effect on gender: absolute prediction error had an impaired driving effect on reinforcement learning and episodic memories in the female MA group, but not in the male MA group.
Conclusion
Males with MA use disorder can learn from unexpected reward feedback, but females are less able to learn much, and their episodic memories of past feedback results could not guide them to make adaptive behaviors. The gender difference may explain the greater impairment in some executive functions and greater involvement in criminal activity among females with MA use disorder.
Software Quality Sustainability Measurement Using Machine Learning Algorithms
Authors: Siri D , Rao H Kalyan , Jyothi V. , Apurva Apurva Khandekar , neelima G Neelima , nagender Nagender Babu 
Published: November 2023

Abstract
Software quality is of paramount importance. Software quality can be directly affected by software defect prediction. This topic has become a hot topic over the past few years. Software defects can have a key role on the software quality, leading to higher maintenance costs, overruns, delays, and increased costs. This paper discusses the Machine-learning algorithms - ANN (Particle Swarm Optimization), DT (Decision Trees), NB(Naive Bayes), DT (Decision Trees), DT (Decision Trees), DT (Decision Trees), DT (Decision Trees), DT (Decision Trees), DT (Decision Trees), LC [Linear Classifier]).Software quality is dependent on the ability to predict faults. This helps reduce the time and cost of software testing. Software metrics can be used to determine the program's difficulty and duration. Software metrics can also be used to predict module faults. This requires extensive research. This empirical research seeks to identify the factors that significantly improve fault prediction models and related product metrics. This paper discusses software metrics and offers suggestions for improving software defect prediction.
Optical Design and Optimization of Space High-cadence Observing Terahertz-telescope (SHOT)
Authors: Zhang MIngzhu , Duan Ran , Li Di , Zhang Xiaohang , Yang Lihui , Liu Fei , Wang Yu , Yu Shiling , Ma Xiaoyun , Yan Xiaohui 
Published: November 2023

Abstract
The Space High-cadence Observing Telescope (SHOT) is proposed to conduct a wide-field survey in 1-3 THz with an aperture of 1-meter class. It will provide complete terahertz and far-infrared photometry with low-resolution spectroscopy throughout the sky, promoting the study of fast radio bursts, the formation and evolution of stars, and other scientific goals. The telescope will adopt a superconducting kinetic inductance detector to achieve a wide survey of terahertz imaging. This work designs the optical system of SHOT to obtain a large FOV of up to 1.5 deg and match the detector with the size of 60 mm\(\times\)60 mm and pixel pitch of 0.8 mm. The quasi-optical system adopts a Ritchey-Chr{\'e}tien design. By adding a corrector lens to the optical system and optimization, the aberrations mainly caused by the optical elements in the detector system are reduced. The influence of each component assigned to different terahertz materials is analyzed. The results show that TPX is more suitable than the other two materials. The performance of the optimized optical system is close to its diffraction limit. It will have the characteristics of high image quality and compact layout.
Challenges and Opportunities of Virtual Reality Painting Animation in Mainland China: A Case Study of Dark Tide
Authors: Tan Bowen , Qiu Yilun , Zeng Zhi , Rascoe Roderick 
Published: November 2023

Abstract
This article draws on the experience of producing the music video Dark Tide in Quill, a virtual reality painting software, to discuss the potential of integrating virtual reality (VR) technology into the animation industry workflow. Despite significant updates in VR content-creation technologies over the past seven years, many animation companies in Mainland China are reluctant to include these innovative technologies in their animation production workflows due to a lack of knowledge and drawbacks in the VR workflow. However, in light of uncertainty within the animation market and the commercial success of independent animation, VR painting technology could provide start-up animation studios with an alternative animation production workflow and production strategies for their future projects. Against this background, we examine the current advantages and limitations of Quill.