bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Retrospective Cohort Study of At-Home Catheter Removal After Urogynecologic Surgery
Authors: Davenport Abigail P. , Li Yi W. , Lefbom Lucie T. , Iglesia Cheryl B. , Dieter Alexis A. 
Published: February 2024

Importance
In-office postoperative voiding trials (VTs) increase health care burden for patients and physicians. Adoption of an at-home VT option may decrease burden without increasing adverse events postoperatively.

Objective
The purpose of this study was to compare 30-day postoperative outcomes between participants who performed an at-home autofill VT after catheter self-discontinuation during the Assessing Healthcare Utilization and Feasibility of Transurethral Catheter Self-discontinuation (FLOTUS) study and a “historic” control cohort of patients who presented to the office for backfill-assisted VT on postoperative day (POD) 1.

Study Design
This was a retrospective cohort study of women with postoperative urinary retention after urogynecologic surgery between June 2020 and March 2022. Outcomes from the FLOTUS study were compared with a “historic” control cohort of patients that were identified on chart review from the year before FLOTUS initiation. Demographic, medical history, and procedure-related data were collected. Thirty-day outcome data included office calls/messages, office visits, emergency department visits, complications, and catheterization outcomes.

Results
Forty-six participants were included in the FLOTUS cohort and 65 participants in the historic cohort. There was no difference in the POD1 VT pass rate, number of office calls/messages, emergency department visits, or postoperative complications between the 2 cohorts. The FLOTUS patients attended 1 less office visit (1 vs 2 office visits, P<0.001), and this difference persisted on regression analysis (−0.87 office visits; 95% CI, −1.18 to −0.56, P<0.001).

Conclusion
Patients who had backfill-assisted VTs on POD1 attended 1 additional office visit compared with those who removed their catheters at home.
Lessons From the Coronavirus Disease Experience
Authors: Sewell Margaret , Neugroschl Judith , Zhu Carolyn W. , Loizos Maria , Zeng Xiaoyi , Pun Kelly , Greenberg Jonathan , Velasco Nelly , Sheppard Faye , Tocco Carly , Evans Kirsten , Ardolino Allison , Meuser Caroline , Li Clara , Melnick Jonah , Grossman Hillel , Sano Mary 
Published: February 2024

Objective:
In New York City in 2020 the pandemic shut down in-person research. Icahn School of Medicine’s Alzheimer’s Disease Research Center transitioned longitudinal evaluations from in-person to telephone to enhance equity of access. We assessed diverse research participants’ and clinical research coordinators’ (CRC) satisfaction with remote evaluation and examined sociodemographic, cognitive, and behavioral factors that might impact satisfaction.

Methods:
Data collected: 241 participants with Clinical Dementia Rating (CDR) = 0/0.5 (3/2020 to 6/2021). A Telehealth Satisfaction Questionnaire for CRCs and participants was administered at the end of remote evaluations. We compared Telehealth Satisfaction Questionnaire items by CDR and Geriatric Depression Scale.

Results:
Participants’ mean age was 78.4, 61.4% were females, 16.2% were Hispanic, 17.1% Asian, 15.8% were non-Hispanic black, and 72.6% CDR = 0. Participant satisfaction was high [14.1 ± 1.4 (out of 15)] but was lower among those with depression. CRC satisfaction was high [16.9 ± 1.8 (out of 18)] but was lower concerning the ability to explain the test battery and interact with participants with CDR = 0.5.

Conclusion:
Telephone research assessments provide flexibility in a hybrid model. They offer equitable access to research participation for those who do not use computer technology and may promote the retention of diverse elderly research participants.
Remission of Obesity-Related Sleep Apnea and Its Effect on Mortality and Cardiovascular Events after Metabolic and Bariatric Surgery: A Propensity-Matched Cohort Study
Authors: Stenberg Erik , Ottosson Johan , Näslund Erik 
Published: February 2024

BACKGROUND:
Although obstructive sleep apnea (OSA) is common among patients with obesity and linked to cardiovascular disease, there is a lack of studies evaluating the effects of reaching remission from OSA after metabolic and bariatric surgery.

STUDY DESIGN:
A registry-based nationwide study including patients operated with sleeve gastrectomy or Roux-en-Y gastric bypass from 2007 until 2019 in Sweden. Patients who reached remission of OSA were compared with those who did not reach remission and a propensity score-matched control group of patients without OSA at the time of operation. The main outcome was overall mortality, and secondary outcome was major cardiovascular events (MACEs).

RESULTS:
In total, 5,892 patients with OSA and 11,552 matched patients without OSA completed a 1-year follow-up and were followed for a median of 6.8 years. Remission of OSA was seen for 4,334 patients (74%). Patients in remission had a lower risk for overall mortality (cumulative incidence 6.0% vs 9.1%; p < 0.001) and MACE (cumulative incidence 3.4% vs 5.8%; p < 0.001) at 10 years after operation compared with those who did not reach remission. The risk was similar to that of the control group without OSA at baseline (cumulative incidence for mortality 6%, p = 0.493, for MACE 3.7%, p = 0.251).

CONCLUSIONS:
The remission rate of OSA was high after metabolic and bariatric surgery. This was in turn associated with reduced risk for death and MACE compared with patients who did not achieve remission reaching a similar risk seen among patients without OSA at baseline. A diligent follow-up of patients who do not reach remission remains important.
General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway
Authors: Liu Bin , Yi Dan , Xia Xiaomei , Ramirez Karina , Zhao Hanqiu , Cao Yanhong , Tripathi Ankit , Dong Ryan , Gao Anton , Ding Hongxu , Qiu Shenfeng , Kalinichenko Vladimir V. , Fallon Michael B. , Dai Zhiyu 
Published: February 2024

AbstractPulmonary arterial hypertension (PAH) is characterized by a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling that result in right heart hypertrophy, failure, and premature death. The underlying mechanisms of loss of distal capillary endothelial cells (ECs) and obliterative vascular lesion formation remain unclear. Our recent single-cell RNA sequencing, spatial transcriptomics analysis, RNASCOPE, and immunostaining analysis showed that arterial ECs accumulation and loss of capillary ECs were evident in human PAH patients and pulmonary hypertension (PH) rodents. Pseudotime trajectory analysis of the single-cell RNA sequencing data suggest that lung capillary ECs transit to arterial ECs during the development of PH. Our study also identified CXCL12 as the marker for arterial ECs in PH. Capillary EC lineage tracing approach using capillary specific-Dre;Tdtomato reporter mice demonstrated that capillary ECs gave rise to arterial ECs during PH development. Genetic deletion of HIF-2a or pharmacological inhibition of Notch4 normalized the arterial programming in PH. In conclusion, our study demonstrates that capillary endothelium transits to arterial endothelium through the HIF-2a-Notch4 pathway during the development of PAH. Thus, targeting arterial EC transition might be a novel approach for treating PAH patients.
LIVED EXPERIENCES OF MOTHERS WITH PERIPARTUM CARDIOMYOPATHY
Authors: Mukona Doreen , Tsiko Barbara , Zvinavashe Mathilda 
Published: February 2024

Peripartum cardiomyopathy is known to occur more commonly in African women or those of African descent, with potentially devastating consequences. The purpose of this study was to explore the lived experiences of women with post-partum cardiomyopathy. A phenomenological approach was used. The study was conducted with 6 women with a confirmed diagnosis of peri-partum cardiomyopathy who were registered with the Parirenyatwa Group of Hospitals Cardiac clinic. Excluded from the study, due to compromised autonomy, were the mentally ill, critically ill, and the institutionalized. Participants were selected as they came for routine management. In-depth interviews, following semi structured questionnaires, were conducted. All participants gave informed consent, and the study was conducted according to the requirements of the Declaration of Helsinki. Interviews were held in a private room and filled in questionnaires and detailed notes were anonymized and kept in a lockable cupboard to which the researchers had sole access. Manual thematic analysis was used to analyze the data and it was presented in themes, subthemes, and codes. The stages of thematic analysis followed were data organization, familiarization, transcription, coding, identifying themes, indexing, reviewing themes, displaying, and reporting. Trustworthiness was ensured by observing credibility, dependability, confirmability, and transferability. Three major themes namely: experience on diagnosis, psychosocial tension and supporting factors were identified. Women diagnosed with peripartum cardiomyopathy experience physical, psychological, and emotional stress. Psychosocial support is very vital in the management of peripartum cardiomyopathy.
A Machine Learning Classification of Individuals with Mild Cognitive Impairment into Variants from Writing
Authors: Kim Hana , Hillis Argye , Themistocleous Charalambos 
Published: February 2024

AbstractIntroductionIndividuals with Mild Cognitive Impairment (MCI), a transitional stage between cognitively healthy aging and dementia, are characterized by subtle neurocognitive changes. Clinically, they can be grouped into two main variants, namely into patients with amnestic MCI (aMCI) and non-amnestic MCI (naMCI). The distinction of the two variants is known to be clinically significant as they exhibit different progression rates to dementia. However, it has been particularly challenging to classify the two variants robustly. Recent research indicates that linguistic changes may manifest as one of the early indicators of pathology. Therefore, we focused on MCI’s discourse-level writing samples in this study. We hypothesized that a written picture description task can provide information that can be used as an ecological, cost-effective classification system between the two variants.MethodsWe included one hundred sixty-nine individuals diagnosed with either aMCI or naMCI who received neurophysiological evaluations in addition to a short-written picture description task. Natural Language Processing (NLP) and BERT pre-trained Language Models were utilized to analyze the writing samples.ResultsWe showed that the written picture description task provided 90% overall classification accuracy for the best classification models, which performs better than cognitive measures.DiscussionWritten discourses analyzed the AI models can automatically assess individuals with aMCI and naMCI and facilitate diagnosis, prognosis, therapy planning, and evaluation.
Impact of riceGENERAL REGULATORY FACTOR14h(GF14h) on low-temperature seed germination and its application to breeding
Authors: Sugimura Yusaku , Oikawa Kaori , Sugihara Yu , Utsushi Hiroe , Kanzaki Eiko , Ito Kazue , Ogasawara Yumiko , Fujioka Tomoaki , Takagi Hiroki , Shimizu Motoki , Shimono Hiroyuki , Terauchi Ryohei , Abe Akira 
Published: February 2024

AbstractDirect seeding is employed to circumvent the labor-intensive process of rice (Oryza sativa) transplantation, but this approach requires varieties with vigorous low-temperature germination (LTG) when sown in cold climates. To investigate the genetic basis of LTG, we identified the quantitative trait locus (QTL)qLTG11from rice variety Arroz da Terra, which shows rapid seed germination at lower temperatures, using QTL-seq. We delineated the candidate region to a 52-kb interval containingGENERAL REGULATORY FACTOR14h(GF14h) gene, which is expressed during seed germination. The Arroz da TerraGF14hallele encodes functional GF14h, whereas Japanese rice variety Hitomebore harbors a 4-bp deletion in the coding region. Knocking out functionalGF14hin a near-isogenic line (NIL) carrying the Arroz da Terra allele decreased LTG, whereas overexpressing functionalGF14hin Hitomebore increased LTG, indicating thatGF14his the causal gene behindqLTG11. Analysis of numerous Japanese rice accessions revealed that the functionalGF14hallele was lost from popular varieties during modern breeding. We generated a NIL in the Hitomebore background carrying a 172-kb genomic fragment from Arroz da Terra includingGF14h. The NIL showed superior LTG compared to Hitomebore, with otherwise comparable agronomic traits. The functionalGF14hallele from Arroz da Terra represents a valuable resource for direct seeding in cold regions.Author SummaryRice serves as a fundamental crop sustaining over half of the global population. With the rapid growth of the world’s population, it will become increasingly important to improve rice productivity. On the other hand, the aging of rice farmers in Japan has resulted in a constant labor shortage. To address this, direct seeding, in which seeds are sown directly in rice fields without going through the most labor-intensive part of the rice cultivation process, i.e., seedling production and transplanting, has been recommended. However, prevalent elite rice varieties are known to be unsuitable for direct seeding due to their poor seed germination ability under low-temperature conditions. In this study, we show for the first time thatGF14hgene from the Portuguese variety Arroz da Terra improves seed germination at low temperatures (LTG). In addition, a novel cross-bred line was generated by introducing theGF14h-containing genomic segment from Arroz da Terra into Hitomebore, a widely cultivated variety in northern Japan. This line is expected to be used as a pre-breeding material to enhance LTG. This study will provide a genetic basis for LTG and contribute to basic and applied research progress.
Prenatal Stress Alters Transcription of NMDA-Type Glutamate Receptors in the Hippocampus
Authors: Buck Tristram , Dong Erbo , Guidotti Alessandro , Sodhi Monsheel 
Published: February 2024

AbstractPrenatal stress damages the development of the cortico-hippocampal circuit in the brain and increases the risk for neurological disorders associated with deficits of social behavior, including schizophrenia. Accumulating evidence indicates that the NMDA-type glutamate receptor plays an important role in social cognition and stress-induced pathology in the hippocampus. In this study we have tested the hypothesis that transcription of NMDAR subunits is modified in the frontal cortex and hippocampus of prenatally stressed mice. Prenatal stress exposure was conducted by exposing pregnant mice to restraint stress three times daily during gestational weeks 2 and 3. We treated the adult offspring with haloperidol (1mg/kg), clozapine (5mg/kg) or vehicle (saline) twice daily for 5 days, after which we measured social interaction behavior (SI) and locomotor activity. After euthanasia, we measured the transcription of NMDAR subunits in the hippocampus and frontal cortex. We observed that saline-treated prenatally stressed (PRS-Sal) mice had reduced social interaction (SI) behavior compared to controls (NS-Sal) (P<0.01). This deficit was recovered in PRS mice treated with clozapine (PRS-Clz) but not the haloperidol-treated PRS group (PRS-Hal). These changes were not due to suppressed locomotion as neither PRS nor antipsychotic treatment reduced locomotor activity. These effects of prenatal stress were associated with increased transcription of NMDAR subunits (GRIN genes) in the hippocampus but not the frontal cortex. We observed positive correlation between GRIN transcription and social behavior in the frontal cortex, and conversely, negative correlation between GRIN transcription and social behavior in the hippocampus. Studies indicate that transcription of NMDARs is activity dependent, therefore altering the transcription levels of different NMDAR subunits would have a significant impact on the excitatory transmission in the corticolimbic circuit. The results suggest a molecular pathway by which prenatal stress in mice leads to life-long deficits in social behavior. It’s worth noting that while these associations have been observed in mice, the direct translation to human prenatal stress and NMDA receptor alterations requires further investigation. Nevertheless, these findings contribute to our understanding of the impact of prenatal stress on pathology in the hippocampus and downstream effects on social behavior and may have implications for understanding neuropsychiatric disorders related to prenatal stress exposure.
Construction and application of a technical platform for determining cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles
Authors: Wang Yisha , Luo Gan , Wang Haiyang , Zheng Yue , Xu Xiao , Zhou Wenbin , Lin Junrong , Chen Baocheng , Jin Yifeng , Sui Meihua 
Published: February 2024

AbstractCellular accumulation of biomedical nanoparticles could be affected by cellular biological properties. However, little is known about the influence of cell cycle and autophagy on nanoparticle accumulation. What’s even more tough is that several long-lasting methodological barriers have hampered the experimental performance and restricted related research progress. Herein, a multi-functional platform was constructed for simultaneously overcoming existing obstacles by integrating several technical approaches, particularly mitotic shake-off, for thorough cell cycle phase separation. Strikingly, application of this platform revealed that G2-phase and M-phase cells, two cell populations previously muddled up together as G2/M-phase cells, respectively exhibited the maximum and minimum accumulation of lipid-based nanoparticles. Moreover, although further verification is needed, we have provided a novel line of evidence for enhanced nanoparticle accumulation by autophagy blockade. Besides providing a technical solution, this study discovered characteristic cell cycle- and autophagy-associated nanoparticle accumulations that may offer new insights for optimization and application of nanomedicines.
Personality in individuals with mild intellectual disability to borderline intellectual functioning: a comparative study
Authors: Lie Sam Foek-Rambelje Kim , Copier Kirsten , Didden Robert , Haacke Esmay , van der Heijden Paul , Egger Jos 
Published: February 2024

PurposeThis study aims to investigate the distinctive personality traits and characteristics of individuals with borderline intellectual functioning (BIF) and mild intellectual disability (MID) within specialized centers for MID-BIF treatment and care compared with individuals without MID-BIF diagnosis gathered from general mental health care (GMH) settings.Design/methodology/approachPatients classified with MID-BIF (n= 58), most with comorbid psychopathology, were thoroughly interviewed by trained clinicians who afterward completed the Shedler–Westen Assessment Procedure (SWAP-200) about the patient. The authors compared SWAP-200 profiles of MID-BIF patients with profiles of GMH individuals. In addition, the authors have compared these profiles for the MID and BIF groups (differentiated based on previously known intelligence quotient scores).FindingsResults show significantly higher scores for the MID-BIF group than the GMH group on scales encompassing emotional instability, impulsivity and antagonism. On scales containing constraint and healthy traits, significantly lower scores were found for the MID-BIF group than for the GMH group. Importance of including SWAP-200 personality assessment for a more comprehensive understanding and treatment planning for individuals with MID-BIF is discussed.Originality/valueThis study offers insights into personality within individuals with an MID-BIF diagnosis, compared with individuals in a GMH setting.
Analysis of data-driven approaches for radar target classification
Authors: Coşkun Aysu , Bilicz Sándor 
Published: February 2024

Purpose
This study focuses on the classification of targets with varying shapes using radar cross section (RCS), which is influenced by the target’s shape. This study aims to develop a robust classification method by considering an incident angle with minor random fluctuations and using a physical optics simulation to generate data sets.

Design/methodology/approach
The approach involves several supervised machine learning and classification methods, including traditional algorithms and a deep neural network classifier. It uses histogram-based definitions of the RCS for feature extraction, with an emphasis on resilience against noise in the RCS data. Data enrichment techniques are incorporated, including the use of noise-impacted histogram data sets.

Findings
The classification algorithms are extensively evaluated, highlighting their efficacy in feature extraction from RCS histograms. Among the studied algorithms, the K-nearest neighbour is found to be the most accurate of the traditional methods, but it is surpassed in accuracy by a deep learning network classifier. The results demonstrate the robustness of the feature extraction from the RCS histograms, motivated by mm-wave radar applications.

Originality/value
This study presents a novel approach to target classification that extends beyond traditional methods by integrating deep neural networks and focusing on histogram-based methodologies. It also incorporates data enrichment techniques to enhance the analysis, providing a comprehensive perspective for target detection using RCS.
Sustaining talent: a social exchange perspective on the Generation Z workforce
Authors: Chaudhry Smita 
Published: February 2024

Purpose
The paper aims to conceptually identify the organizational conditions and therefore the possible areas of intervention, in the domains of work, growth potential and culture, which would help the Generation Z workforce be more engaged, motivated and committed to the organization.

Design/methodology/approach
The paper adopts a typology methodology, taking into account the specific characteristics of Generation Z. It describes a conceptual framework, drawing on three fundamental aspects of social exchange theory in the context of workplace (organizational justice, organizational support and leader-member exchange), and applying them to three dimensions of organizational life (work, growth potential and culture).

Findings
The paper suggests certain organizational conditions, in the domains of work, growth potential and culture, which can align Generation Z workforce to the organization. It accordingly indicates desirable interventions in the areas of job design, training, performance and compensation systems, work policies, leadership and communication.

Originality/value
The paper identifies organizational conditions for sustaining Generation Z talent, based on their specific characteristics. There is limited evidence of such studies for Generation Z in the literature. The paper adopts a structured and systematic approach involving typology methodology. By taking a holistic and theoretical perspective on ways to enhance Generation Z engagement, the paper seeks to address an existing gap in the literature.