bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring transition to practice for newly qualified midwives
Authors: Malott Anne M. , Murray-Davis Beth , RM Christine Sandor 
Published: December 2023

Abstract
Background: It can be overwhelming for newly qualified midwives to begin to work independently due to added responsibility and isolation. A support program was introduced in Ontario, Canada in July 2022 to provide educational resources, peer support and opportunities for reflection on clinical decision-making. This study assesses the extent to which the program assists transition through the first year of practice for new midwives.
Methods: We conducted qualitative semi-structured interviews and focus groups with newly qualified midwives and their mentors following a Grounded Theory Methodology for data collection and analysis.
Findings: Data collection from nine participants from July 1, 2022-June 1, 2023, produced four main themes: (1) peer support, (2) building relationships, (3) continuum of autonomous practice, and (4) value of resources which generated a theory explaining how participation in a community of practice (CoP) promotes confidence and enhances transition to autonomous practice for new midwives.
Conclusion: Support is critical for newly qualified midwives to build confidence, reduce isolation and promote adjustment socially and in practice. A CoP is an effective and valued approach to facilitating this process.
The Impact of a Student-Faculty Telehealth Program on Student Education and Patient Care
Authors: Dor Betty Ben , Zhang Andrew Y. , Tiu Bruce C. , Bahar Piroz , Shah Kavya M. , Cheloff Abraham Z. , Kruse Gina R. , Weinstein Amy R. 
Published: December 2023

Abstract
Background and Objectives:
The COVID-19 pandemic has presented many opportunities for health professions students to gain proficiency in telemedicine while supporting patients. We evaluated the pedagogical impact of a diabetes telehealth program on patient and student satisfaction.
Methods
Health professions students were surveyed prior and after serving in a diabetes telemedicine program to assess satisfaction with the intervention and its educational impact. Post-program participant satisfaction was assessed via surveys.
Results
Of 54 students surveyed, there were 26 pre-program respondents and 10 post-program respondents. Post-program, students felt more capable of performing diabetes-focused histories and physicals (audio p = 0.03; video p = 0.01) and discussing blood glucose monitoring (audio p = 0.02; video p = 0.03). Students felt more comfortable counseling patients about lifestyle modification in video but not audio visits (video p = 0.03, audio p = 0.28). Student impressions of telemedicine effectiveness did not change post-program. Challenges student providers noted included continuity of care, technical difficulties, limitations in providing clinical support and decreased ability to develop rapport. Of 60 patients surveyed, 33 respondents noted the convenience of telehealth visits, patient-centeredness of the program and empathy of the student providers as key strengths.
Conclusions
Although student confidence in clinical skills improved and patients were satisfied with telemedicine, students’ satisfaction with telemedicine did not change after involvement. More work is needed to educate students on effective telehealth interventions and improve existing telehealth infrastructure to support patient-centered care.
HnRNPK is essential for Sertoli cells development and male fertility in mice
Authors: Zheng Yueqian , Cheng Xiaofang , Bai Yueyu , Guo Jiahua , Zhang Mengjia , Huang Yueru , Wang Yuxi , Li Quanxi , Xia Lianren , Wu Wenyan , Li Cencen , Zhang Pengpeng , Xu Haixia , Xu Yongjie 
Published: December 2023

Abstract

Background:Sertoli cells (SCs), a type of somatic supporting cells situated within the spermatogenic niche, play a crucial role in the maturation of germ cells. Nevertheless, the precise mechanisms governing the development of SCs and their impact on spermatogenesis remain incompletely understood.Results:In this study, we have identified hnRNPK, a multifunctional protein involved in signal transduction and gene expression regulation, as a significant novel regulatory factor in the development of neonatal SCs and pre-pubertal testicular growth in mice. In order to gain a deeper understanding of the roles played by hnRNPK in spermatogenesis, we conducted a thorough investigation utilizing SCs specificHnrnpkknockout mice, which were obtained through the crossing ofHnrnpkflox/floxmice withAmh-Cre mice. The findings demonstrated that the absence ofHnrnpkin SCs had a significant impact on various aspects, including the proliferation and localization of SCs, the organization of seminiferous tubules, the occurrence of apoptotic cell death in both SCs and germ cells within the tubules, as well as the reduction in testis size and overall fecundity. Through the integration of RNA-seq and bioinformatics analysis, our study has unveiled the dysregulation of the transcriptome-wide expression of crucial genes involved in the control of SCs and germ cells fate. These genes encompass various processes, including cell-cell adhesion, cell proliferation and migration, piRNA processing, SC differentiation, and secretion.Conclusions:Our findings highlight the indispensable role of hnRNPK in SCs for the development of the testis and also shed light on a previously unknown function of hnRNPK in male germ cell survival and differentiation, specifically by modulating cell-cell communication.
Gene mutations and clinical features of pediatric sitosterolemia
Authors: Gu Rui , Wang Hui , Wang Chun-Lin , Lu Mei , Miao Miao , Huang Meng-Na , Chen Yi , Dai Yang-Li , Zhu Ming-Qiang , Zhou Qiong , Zou Chao-Chun 
Published: December 2023

Abstract

Objective To improve the diagnosis, treatment and follow-up of childhood sitosterolemia by analyzing the phenotypes and genotypes in Chinese pediatric patients with sitosterolemia. Methods The cohort included 26 children with sitosterolemia, 24 of whom underwent genetic testing. Their family history, clinical features, and biochemical indicators, including liver function, blood fat, routine blood test, phytosterol analysis, cardiac and carotid artery ultrasound, fundus examination, genetic analysis results and therapy, were collected and analyzed. Results Among 26 patients, the most common manifestation was xanthomas, which were found in 19 (73.1%). Others were arthralgia (7, 26.9%) and growth retardation (4, 15.4%). Among 24 (92.3%) patients who underwent genetic analysis, 16 (%) hadABCG5mutations (type 2), and 8 (34.8%) hadABCG8mutations (type 1). Moreover, the c.1166G > A (p. Arg389His) ofABCG5was the most hot spot mutation, which was found in 10 patients (66.7%). There were no significant differences in clinical manifestations or laboratory tests between type 1 and type 2 (all p > 0.05). Nonsense mutations were more likely inABCG5, with a marginally significant difference (p = 0.09), while splicing mutations were more common inABCG8(p = 0.01). After diet or conjointed ezetimibe treatment, there was a significant decrease in total cholesterol and low-density lipoprotein cholesterol compared to before treatment. Conclusion In patients with xanthomas and elevated cholesterol, sitosterolemia needs to be considered. Phytosterols and genetic testing should be performed for early diagnosis. Diet control and treatment with ezetimibe can relieve the disease. A larger clinical sample was used to investigate the relationship between genotype and phenotype.
Application of SS- OCTA to evaluate the effects of long- term hydroxychloroquine treatment on retinal structure and microcirculation in patients with systemic lupus erythematosus
Authors: Li Xuemei , Xiong Chao , Luo Shuilin , Chen Yunxiu , Li Min , Wang Shiyi , Wang Yaohua , Wang Zhilin , Wu Rui , Liao Hongfei 
Published: December 2023

Abstract
Propose The application of swept-source optical coherence tomography angiography (SS-OCTA)technique is used to detect the effects of long-term use of hydroxychloroquine (HCQ) on retinal structure and microcirculation in patients with systemic lupus erythematosus (SLE) before visual dysfunction occurs.
Methods Retrospective case-control study. A total of 73 SLE patients (73 eyes) who had taken HCQ regularly for a long period of time were included as the SLE patient group, while 21 healthy individuals (21 eyes) were included as the control group. Based on the duration of HCQ use (HCQ course), the SLE patient group was divided into baseline group(6 months ≤ medication time< 1 year), low-risk group ( 1 year ≤ medication time < 5 years), and high-risk group (medication time ≥ 5 years). All participants underwent bilateral SS-OCTA macular imaging(6mm*6mm), slit-lamp examination, non-contact tonometry, computerized visual field (30-2) test, and fundus autofluorescence imaging (FAF).
Results Compared with the control group, the thickness of the inner retina of the central fovea, the inner retina of the parafoveal area, and the outer retina in three areas, as well as the superficial vessel density in the central fovea, inner ring below, and outer ring were decreased in the SLE patient group,while the FAZ area and circumference increased (P<0.05). In comparison to the SLE patients, the high-risk group showed a decrease in the inner retinal thickness, full retinal thickness of the macular area (6mm*6mm), and shallow retinal blood flow density in the central foveal area, temporal periphery, and superior periphery. Additionally, the FAZ (foveal avascular zone) area and perimeter increased (P<0.05). Correlation analysis showed that the duration of SLE, cumulative dose of HCQ and the thickness of the total retina in three regions including inner retinal layer, central foveal area, and inner superior and temporal quadrant SCP-VD were negatively correlated (r<0, P<0.05), while the FAZ area and perimeter were positively correlated (r>0, P<0.05).
Conclusion Analysis by SS-OCTA examination showed that long-term HCQ treatment had adverse effects on the inner retina, SCP-VD and FAZ parameters in subclinical SLE patients without visual impairment.
Deciphering Potential Role of Hippo Signaling Pathway in Breast Cancer: A
Comprehensive Review
Authors: Bhavnagari Hunayna , Raval Apexa , Shah Franky 
Published: December 2023

Abstract:
Breast cancer is a heterogeneous disease and a leading malignancy around the world. It is a vital
cause of untimely mortality among women. Drug resistance is the major challenge for effective cancer therapeutics.
In contrast, cancer stem cells (CSCs) are one of the reasons for drug resistance, tumor progression,
and metastasis. The small population of CSCs present in each tumor has the ability of self-renewal, differentiation,
and tumorigenicity. CSCs are often identified and enriched using a variety of cell surface markers (CD44,
CD24, CD133, ABCG2, CD49f, LGR5, SSEA-3, CD70) that exert their functions by different regulatory networks,
i.e., Notch, Wnt/β-catenin, hedgehog (Hh), and Hippo signaling pathways. Particularly the Hippo signaling
pathway is the emerging and very less explored cancer stem cell pathway. Here, in this review, the Hippo
signaling molecules are elaborated with respect to their ability of stemness as epigenetic modulators and
how these molecules can be targeted for better cancer treatment and to overcome drug resistance.
Quinolone Tethered 1,2,3-triazole Conjugates: Design, Synthesis, and Computational
Docking Studies on New Heterocycles as Potent Antimicrobial Targets
Authors: Basireddy Avanthi , Allaka Tejeswara Rao , Allam Avekananda Reddy , Baddam Sudhakar Reddy , Basireddy Sravanthi , Kishore Pilli Veera Venkata Nanda 
Published: December 2023

Abstract:
The synthesis and biological properties of molecules simultaneously comprising
various heterocycles, such as fused 2-quinolones and 1,2,3-triazoles, have been evaluated
as a part of our ongoing research in medicinal and organic chemistry. We were successful
in developing a synthetic procedure for 1,2,3-triazole substituted quinolone derivatives. Infrared,
proton, and carbon nuclear magnetic resonance, mass spectroscopy and elemental
analysis were used to characterise the structures of the recently synthesised triazole derivatives.
From screening results, all the compounds demonstrated increased antibacterial action
against both Gram-positive and Gram-negative bacteria. Moreover, 1,2,3-triazoles
linked to tert-butyl benzyl (3a), trifluoromethyl benzyl (3b), 3-chlorobenzyl (3c), 4-
hydroxy-3-nitrobenzyl (6b), 4-hydroxy-4-trifluoromethylbenzyl (6d), and 4-hydroxy-2,4-
difluorobenzyl (6e) compounds showed promising antibacterial and antifungal activities with MICs values of
1.07-4.33 μg/mL. The prepared ligand 4-hydroxy-2,4-difluoro benzyl-1,2,3-triazole (6e) exhibited the highest
docking score of -6.34 kcal/mol and showed interacting amino acid residues ArgB:1122, MetB:1121, AspB:1083,
TryB:1087, AlaB:1118, AlaB:1120, GluB:1088, GlyB:1117, SerB:1084, and AlaB:1119 within the active site of 2XCT. Final
scaffolds were further evaluated for their ADMET and physicochemical properties by using ADMETlab2.0
and SwissADME web servers as good oral bioavailability drugs.
Novel Chalcone Derivatives Containing Pyridone and Thiazole Moieties: Design,
Synthesis, Molecular Docking, Antibacterial, and Antioxidant Activities
Authors: Borik Rita M. 
Published: December 2023

Abstract:
A new series of chalcones 4a-i; 6a,b, and 8 was synthesized from the condensation
of ketone 2, which was prepared from the reaction of thiourea derivative 1 with 3-
chloropentane-2,4-dione in MeOH at reflux temperature, with substituted aromatic/
heterocycle aldehydes in EtOH containing NaOH at room temperature. Antimicrobial
and antioxidant activities were assessed for the synthesized compounds. The antimicrobial
susceptibility tests revealed that compounds (4c, 4e, 4f, and 4i) exhibited good to excellent
activity against C. albicans, S. aureus ATCC25923, E. faecalis ATCC29212, P. aeruginosa
ATCC10145, and S. mutans ATCC25175. The antioxidant capabilities were assessed using
the DPPH and ABTS radical scavenging methods. Compounds (4b, 4c, 4d, and 4e) proved
to be better at scavenging DPPH and ABTS. This study involved in-silico drug-likeness and
physicochemical properties and evaluated their ADMET profiles. According to the results of the molecular
docking simulation, the synthesized compounds showed lower binding energy at the active sites of Dihydropteroate
synthase, Sortase A, LasR, and Penicillin-binding protein pockets, which suggests that they may have an
inhibitory effect on the enzymes and show promise as antimicrobial agents.
Unlocking Multifunctional Advantages with Nanocomposites Coatings for Solar
Cells: A Comprehensive Review
Authors: Regmi Ganesh 
Published: December 2023

Abstract:
Nanocomposite coatings have garnered considerable attention as a versatile and
innovative solution for addressing the challenges faced by solar cell technologies. This review
article provides a comprehensive overview of the multifunctional advantages that
nanocomposite coatings offer in the realm of solar cell technology. Furthermore, it delves
into the myriad benefits that nanocomposite coatings bring to the table, including enhanced
light absorption, improved charge carrier dynamics, and augmented protection against environmental
factors such as moisture, UV radiation, and thermal stress. The review also discusses
the diverse materials and fabrication methods employed in the development of nanocomposite
coatings, highlighting their unique properties and practical applications with
multifunctional benefits. Moreover, this comprehensive review explores recent advances in
the field, encompassing the integration of novel nanomaterials, smart coatings, and multifunctional strategies
that enable solar cells to simultaneously exhibit multiple desirable traits. Besides, the review offers insights into
future prospects and challenges, presenting a roadmap for harnessing the full potential of nanocomposite coatings
in solar cell technology. By unlocking the multifunctional advantages of nanocomposite coatings, this review
aims to catalyze further research and innovation, ultimately advancing the prospects of sustainable and
efficient solar energy generation.
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism
Authors: Varshney Prachi , Sharma Vishal , Yadav Devdhar , Kumar Yogesh , Singh Amit , Kagithala Naga Rani , Sharma Pramod Kumar , Porwal Omji , Fuloria Neeraj Kumar , Sharma Pradeep Kumar , Gupta Ashok Kumar , GSN Koteswara Rao 
Published: December 2023

Background:
Cancer drug resistance remains a difficult barrier to effective treatment, necessitating
a thorough understanding of its multi-layered mechanism.

Objective:
This study aims to comprehensively explore the diverse mechanisms of cancer drug resistance, assess
the evolution of resistance detection methods, and identify strategies for overcoming this challenge. The
evolution of resistance detection methods and identification strategies for overcoming the challenge.

Methods:
A comprehensive literature review was conducted to analyze intrinsic and acquired drug resistance
mechanisms, including altered drug efflux, reduced uptake, inactivation, target mutations, signaling pathway
changes, apoptotic defects, and cellular plasticity. The evolution of mutation detection techniques, encompassing
clinical predictions, experimental approaches, and computational methods, was investigated. Strategies to
enhance drug efficacy, modify pharmacokinetics, optimizoptimizee binding modes, and explore alternate protein
folding states were examined.

Results:
The study comprehensively overviews the intricate mechanisms contributing to cancer drug resistance.
It outlines the progression of mutation detection methods and underscores the importance of interdisciplinary
approaches. Strategies to overcome drug resistance challenges, such as modulating ATP-binding cassette
transporters and developing multidrug resistance inhibitors, are discussed. The study underscores the critical
need for continued research to enhance cancer treatment efficacy.

Conclusion:
This study provides valuable insights into the complexity of cancer drug resistance mechanisms,
highlights evolving detection methods, and offers potential strategies to enhance treatment outcomes.
Sesamol: A Phenolic Compound of Health Benefits and Therapeutic
Promise in Neurodegenerative Diseases
Authors: Javed Hayate , Meeran Mohamed Fizur Nagoor , Jha Niraj Kumar , Ashraf Ghulam Md , Ojha Shreesh 
Published: December 2023

Abstract:
Sesamol, one of the key bioactive ingredients of sesame seeds (Sesamum indicum L.),
is responsible for many of its possible nutritional benefits. Both the Chinese and Indian medical
systems have recognized the therapeutic potential of sesame seeds. It has been shown to have significant
therapeutic potential against oxidative stress, inflammatory diseases, metabolic syndrome,
neurodegeneration, and mental disorders. Sesamol is a benign molecule that inhibits the expression
of inflammatory indicators like numerous enzymes responsible for inducing inflammation,
protein kinases, cytokines, and redox status. This review summarises the potential beneficial effects
of sesamol against neurological diseases including Alzheimer’s disease (AD), Parkinson’s
disease (PD), and Huntington’s disease (HD). Recently, sesamol has been shown to reduce amyloid
peptide accumulation and attenuate cognitive deficits in AD models. Sesamol has also been
demonstrated to reduce the severity of PD and HD in animal models by decreasing oxidative
stress and inflammatory pathways. The mechanism of sesamol's pharmacological activities
against neurodegenerative diseases will also be discussed in this review.
Older PLHIV are at Higher Cardiovascular Risk with Poor Quality of Life
Authors: Shabil Muhammed , Murti Krishna , Kumar V Udaya , Kumar Rishikesh , Kumar Nitesh , Dhingra Sameer , Parihar Vipan Kumar , Ravichandiran V , Pandey Krishna 
Published: December 2023

Background:::People with HIV (PLHIV) face increased cardiovascular disease (CVD) risk due to inflammation and immune activation. Aging further amplifies this risk. Limited data exist on CVD risk in older PLHIV in India despite 2.14 million PLHIV with higher CVD risk factors.Methods:::In a cross-sectional study in Bihar, India, 73 PLHIV and 30 control participants were enrolled. Demographics, social factors, clinical information, and CVD risk factors were collected. HbA1c levels and lipid profiles were analyzed, and 10-year CVD risk scores were calculated using the Framingham risk score (FRS) and Qrisk3. Quality of life (QoL) was assessed using WHOQOL- HIV-BREF.Results:::Results showed higher LDL levels in non-HIV older participants and higher HDL levels in younger PLHIV participants. BMI differed significantly, with higher BMI in non-HIV older individuals and lower BMI in younger PLHIV individuals. Older PLHIV participants had significantly higher mean FRS and Q-Risk scores compared to older non-PLHIV and younger PLHIV groups. Among older PLHIV participants, six had higher CVD risk per FRS, while none in the other groups were classified as high CVD risk. Psychological, social relations and spirituality domains were highly deteriorated in older PLHIV, scoring 44.48, 42.72, and 41.2, respectively. The physical domain scored 57.6, and the environment scored 52.72 in the WHOQOL-HIV bref.Conclusion:::In conclusion, older PLHIV in Bihar, India, face higher CVD risk compared to younger PLHIV and non-HIV individuals. FRS and Q-Risk scores effectively assessed CVD risk, identifying higher risk in older PLHIV. Age and BMI were significant predictors of high CVD risk. These findings emphasize CVD risk assessment and tailored management for older PLHIV. The QoL assessment findings indicate moderate deterioration in psychological, social relations, and spirituality domains among older PLHIV individuals. These results suggest greater challenges in psychological well-being, social interactions, and spirituality compared to the overall sample. Further research with larger samples and longitudinal designs is needed to confirm and extend these findings.
Articulate Chemotherapeutic Strategies for the Development of Effective
Drugs against a Fatal Disease, Visceral Leishmaniasis
Authors: Kumar Awanish 
Published: December 2023

Abstract:
Visceral Leishmaniasis (VL) control relies mainly on chemotherapy in the absence of no
effective vaccines. However, available anti-VL drugs are limited in number, having toxicity issues,
adverse reactions, low efficacy, and resistance observed against antileishmanial. A significant decrease
in efficacy (~tenfold increase in dosage and duration) was reported against the usual treatment
with Pentavalent antimonials (the most recommended antileishmanial drug discovered 90
years ago). Amphotericin B is the second line of treatment but limits wider use due to its high cost.
Pentamidine is another anti-VL drug, but its therapeutic efficacy has decreased significantly in different
areas. These conventional therapeutics for VL have become almost outdated due to a significant
increase in therapeutic failure in terms of percentage. Due to this, the search for an effective
future anti-VL drug spans several decades, and now it is in high demand in the current situation.
Some conventional therapeutics are modified, but they are also not satisfactory. Therefore, this article
aimed to discuss conventional and modified therapeutics while emphasizing innovative chemotherapeutic
measures against VL that could speed up the slow pace of antileishmanial drugs and
overcome the drug resistance problem in the future.