bluuebunny/crossref_metadata_2025_split huggingface dataset:
The geomorphological setting, glacial history and Holocene development of 'Kap Inglefield Sø', Inglefield Land, North-West Greenland
Authors: Blake, Jr Weston , Boucherle Mary M. , Fredskild Bent , Janssens Jan A. , Smol John P. 
Published: November 2023

A 115 cm-long core was raised from an irregularly shaped lake informally named 'Kap Inglefield Si,f, 1.5 km southeast of Kap Inglefield, North-West Greenland, at an elevation of 150 m. A 49 cm-thick organic sequence is underlain by banded sediment (sand alternating with clay/silt), deposited in an ice-dammed lake. Today the lake is held up at the outlet by bouldery till containing marine shells. The presence of till containing shells with low D/L ratios for aspartic acid at several inland sites, together with well preserved glacial sculpture along the coast (mirrowing features on nearby Ellesmere Island) and over 80 m of Holocene emergence, provides convincing evidence that an ice stream, draining from coalesced Greenland and Innuitian Ice Sheets over Kane Basin, filled Smith Sound at the last (late-Wisconsinan) glacial maximum. Four 14C age determinations have been made on Core 80-18, and the age of the basal organic sediment is 7210 ± 130 conventional radiocarbon years.
The minerogenic sediment in Core 80-18, rich in rebedded pollen, is lacking in contemporary algae and zoological remains, whereas their number varies throughout the organic part of the core, giving some indication of climate and trophic fluctuations. In the organic sequence only 20 diatom species were recorded, and of these only five taxa were ever present at greater than trace levels. The diatom assemblage was dominated by small Fragilaria species, typical of early postglacial environments from most glaciated lakes, regardless of location or geologic substrate. Their continued abundance throughout the history of this lake reflects the extreme climate of the region. These harsh conditions are also reflected in the fossil Cladocera (Crustacea). Fragments of mosses occurred throughout the organic sequence; Calliergon giganteum dominated at most levels between 5 and 40 cm. A pollen- and microfossil diagram can be divided into five zones. From the bottom upward they are: A. Poaceae pioneer plant zone; B. Salix arctica - Polypodiaceae zone with many pioneer plants; C. Salix arctica zone with high pollen influx; D. Cyperaceae zone with Dryas, Oxyria and Salix; and E. Saxifraga oppositifolia - Papaver zone with many pioneer (fell-field) plants. In this uppermost zone up to 250,000 Pediastrum/ml indicate a slow sedimentation rate, as do the age determinations, probably caused by the development of a nearly permanent ice cover over the central part of the lake. Detailed analysis of the top 7 .6 cm of sediment in a second core revealed drastic changes in the chlorophycean (green algae) fossils. Scenedesmus is dominant below 4.7 cm, whereas Pediastrum is dominant above 4.6 cm. An AMS date of 4050 ± 110 conventional radiocarbon years pinpoints the time at which the cover of lake ice became more permanent.
Close to me. Intercooperation between Cooperative Retailers, Local Food Suppliers and Public Institutions to boost Regional Agrifood Systems. The case of Eroski
Authors: Santos-Larrazabal Josu , Basterretxea Imanol 
Published: November 2023

This paper analyses the intercooperation between public administration, small agricultural producers and the supermarket cooperative Eroski in the Basque and Navarre to promote a local agrifood system. Through a case study with 22 interviews with different members of the system, certain advantages and limitations of intercooperation are identified. The retailer emerges as the main agent with the potential to drive the supply of the local agro-livestock sector and promote its professionalisation through the formation of agricultural cooperatives and other associative networks. The relevance of a correct organisational culture alignment between the retailer and its suppliers and the influence of codependence and power imbalances between these two parties are highlighted. The case offers clues to other retailers who are interested in improving their local positioning, to small local producers wishing to develop their business in a sustainable way with large scale distribution, and to public institutions wishing to promote local agrifood systems in collaboration with large retailers.
Soberanía digital: un debate abierto y tres problemas políticos
Authors: Suárez-Gonzalo Sara 
Published: November 2023

Digital sovereignty: an open debate and three political problems
Resumen: El desarrollo tecnológico digital reciente abre un amplio abanico de nuevas posibilidades. Fundamentalmente en manos de las grandes empresas tecnológicas, sin embargo, representa una amenaza para los sistemas democráticos. En este contexto, se ha intensificado el debate en torno a la soberanía digital. Actores de diversos ámbitos reclaman esta soberanía desde perspectivas y con objetivos diferentes. A la luz de este debate, analizo tres problemas políticos a superar para avanzar hacia la soberanía digital.
Abstract: Recent digital technological development opens up a wide range of new possibilities. Mainly in the hands of the big technological corporations, though, it represents a threat to democratic systems. In this context, the debate on digital sovereignty has intensified. Actors from several fields call for this sovereignty from different perspectives and with various objectives. In light of this debate, I analyse three political problems to overcome in order to move towards digital sovereignty.
Deliberación, polarización y posverdad. Repensar la responsabilidad en la sociedad digital
Authors: Wagner Astrid 
Published: November 2023

Deliberation, polarization and post-truth. Rethinking responsibility for digital societies
Resumen: Ante las tendencias de autocratización y la pérdida de calidad democrática en muchos Estados, el artículo aborda los procesos de polarización que conducen al bloqueo político e institucional y limitan el margen de acción política. Amplificada por la digitalización de la esfera pública y el uso sistemático de desinformación, la polarización conduce a un deterioro de los procesos deliberativos. Esta pérdida de funcionalidad democrática ha dado aliento a un revisionismo democrático tecno-optimista que propone modelos de democracia algorítmica. Frente a los peligros de estas tendencias desenmascaradas como antidemocráticas, perfilamos un concepto de responsabilidad democrática adaptado al entorno de la sociedad digital.
Abstract: In face of autocratization trends and the loss of democratic quality in many states, the article addresses the processes of polarization that lead to political and institutional deadlock and limit the scope for political action. Amplified by the digitization of the public sphere and the systematic use of disinformation, polarization drives a deterioration of deliberative processes. This loss of democratic functionality has encouraged a techno-optimistic democratic revisionism that advocates models of algorithmic democracy. Against the dangers of these trends unmasked as anti-democratic, we outline a concept of democratic responsibility adapted to the digital society environment.
Circular RNA hsa_circ_0051246 acts as a microRNA-375 sponge to promote the progression of gastric cancer stem cells via YAP1
Authors: Deng Minghui , Xu Yefeng , Yao Yongwei , Wang Yiqing , Yan Qingying , Cheng Miao , Liu YunXia 
Published: November 2023

Background
Gastric cancer (GC) stem cells play an important role in GC progression. Circular RNAs (circRNAs) act as microRNA (miRNA) sponges and inhibit the biological function of miRNAs in GC cytoplasm. MiRNAs also participate in GC progress. circ_0051246 was shown to be associated with miR-375 after analyzing GC microarray data GSE78091 and GSE83521. The oncoprotein Yes-associated protein 1 (YAP1) is targeted by miR-375 and can be inactivated via the Hippo tumor suppressor pathway. Due to insufficient research on circ_0051246, this study aimed to investigate its relationship with miR-375 and YAP1 in cancer stem cells (CSCs).

Methods
SGC-7901 CSCs were used to establish knockdown/overexpression models of circ_0051246, miR-375, and YAP1. Malignant phenotypes of CSCs were assessed using Cell Counting Kit 8, colony/sphere formation, 5-Ethynyl-2′-deoxyuridine assay, flow cytometry, Transwell, and wound healing assays. To detect the interactions between circ_0051246, miR-375, and YAP1 in CSCs, a dual-luciferase reporter assay and fluorescence in situ hybridization were performed. In addition, 24 BALB/c nude mice were used to establish orthotopic xenograft tumor models. Four groups of mice were injected with CSCs (1 × 106 cells/100 µL) with circ_0051246 knockdown, miR-375 overexpression, or their respective control cells, and tumor progression and gene expression were observed by hematoxylin-eosin staining, immunohistochemistry. Western blot and quantitative real-time PCR were utilized to examine protein and gene expression, respectively.

Results
Circ_0051246 silencing reduced viability, promoted apoptosis, and inhibited proliferation, migration and invasion of CSCs. The functional effects of miR-375 mimics were comparable to those of circ_0051246 knockdown; however, the opposite was observed after miR-375 inhibitors treatment of CSCs. Furthermore, circ_0051246-overexpression antagonized the miR-375 mimics’ effects on CSCs. Additionally, YAP1 overexpression promoted CSC features, such as self-renewal, migration, and invasion, inhibited apoptosis and E-cadherin levels, and upregulated the expression of N-cadherin, vimentin, YAP1, neurogenic locus notch homolog protein 1, and jagged canonical notch ligand 1. Conversely, YAP1-silenced produced the opposite effect. Moreover, miR-375 treatment antagonized the malignant effects of YAP1 overexpression in CSCs. Importantly, circ_0051246 knockdown and miR-375 activation suppressed CSC tumorigenicity in vivo.

Conclusion
This study highlights the promotion of circ_0051246-miR-375-YAP1 axis activation in GC progression and provides a scientific basis for research on the molecular mechanism of CSCs.
Profile of National Rural Livelihood Mission (NRLM) beneficiaries in Madhya Pradesh
Authors: Rajpoot Ashutosh Singh , Rajan Parvez , Raut Ajay , Srivastava A. , Singh R. B. 
Published: November 2023

The National Rural Livelihoods Mission (NRLM) is a poverty alleviation programme implemented by The Ministry of Rural Development, GOI. The programme aims to promote self-employment and the organization of rural poor. The study was done during 2022-23 in Rewa and Shahdol districts in Baghelkhand region of Madhya Pradesh based on highest number of beneficiaries registered in selected districts under NRLM in the state of Madhya Pradesh. In this study Ex-post facto research design, and proportionate random sampling technique was adopted at 3 percent under multi-stage sampling procedures. Thus 221 respondents were selected which were personally interviewed to known the profile of beneficiaries. The results revealed that 65.60 percent of beneficiaries belong to young age, 24.00 percent have high school level of education, 47.07 percent have medium size of family, 55.20 percent have low level of farming experience, 50.20 percent have medium level of income, 53.86 percent have medium level credit accessible, 47.52 percent have marginal land holding, 38.00 percent had low level of information seeking behaviour, 41.17 percent have high level of mass media exposures, 39.82 percent have medium level of risk preference, 43.43 percent have medium level of awareness towards diversification, 51.58 percent have medium level of economic motivation, 46.15 percent have medium level of innovative, 41.65 percent have medium decision-making ability and 39.80 percent of beneficiaries have low level of management efficiency.
The Impact and Benefits of the E-System for Administration Management in Primary and Secondary Schools for Teachers and Parents
Authors: Ramadani Refik , Mustafa Ragmi , Mustafa Kujtim 
Published: November 2023

This research aims to identify the impact of the E-management system on the work of teachers, parents, and students. Enrolling students with all the information and keeping grades, behaviors, activities, and, most importantly, analytical reports should be an easy process for teachers through the E-system. Parents can track their child's progress at the right time while students receive teacher notifications, complete quizzes, access their success, track their shortcomings, and many other benefits.
The paper focuses on the following research objectives: the impact of the Management System on the organization of the teacher's class, research on the effects of the Management System in creating and generating analytical reports for each student, analysis of the impact of the Management System on the communication of the teacher with students as well as with parents, Investigating the effects of the Management System on the teacher's will and researching the impact of the Management System on commitment and work by the teacher.
Small socketed axeheads from northern Britain
Authors: Paul Ella B , Knight Matthew G , Cowie Trevor G , Troalen Lore 
Published: November 2023

In 2019 a miniature bronze socketed axehead was discovered near Morebattle, Scottish Borders. As such artefacts are rare finds in northern Britain, the opportunity has been taken to draw together the range of unusually small socketed axeheads recorded from Scotland and northern England, and to discuss them in their wider British context. For the first time, scientific techniques are applied to these objects, including optical microscopy, X-ray fluorescence analysis and computed X-radiography, to inform discussions of wear analysis, material composition, manufacture and chronology. The paper concludes with a discussion of the function and meaning of small socketed axeheads and their changing role over time.
Canmore ID 25199
Canmore ID 55084
Canmore ID 69801
Canmore ID 11986
Excavation and survey at the Giant’s Grave, Slochd Measach, Nereabolls, a Neolithic chambered cairn on the Isle of Islay, Argyll & Bute
Authors: Mithen Steven , Maričević Darko , Berg-Hansen Inger M , Elliott Sarah , Fry Rob , Pelling Ruth , Sheridan Alison 
Published: November 2023

The ‘Giant’s Grave’, formally known as Slochd Measach, Nereabolls, (SM3927) is located on the Isle of Islay in western Scotland and is one of seven confirmed Clyde Cairns on the island. We describe the standing remains and excavations between 2015-18 intended to address the origin, architecture and use of this monument. We found that the cairn was most likely constructed between 3516-336 cal BC in one continuous effort. It was modified and reused on at least four occasions during the Early and Late Bronze Age, and extensively robbed during the Iron Age. This post-Neolithic activity left a small collection of ceramic vessels may have been used for funerary purposes of votive offerings. We compare the architecture of the Giant’s Grave with that of other cairns on Islay and in the wider region.
Canmore ID 37355
Microstructural Welding Engineering of Carbon Nanotube/Polydimethylsiloxane Nanocomposites with Improved Interfacial Thermal Transport
Authors: Zhang Fei , Sun Yuxuan , Guo Lei , Zhang Yinhang , Liu Dan , Feng Wei , Shen Xi , Zheng Qingbin 
Published: November 2023

AbstractCarbon nanotube (CNT) reinforced polymer nanocomposites with high thermal conductivity show a promising prospect in thermal management of next‐generation electronic devices due to their excellent mechanical adaptability, outstanding processability, and superior flexibility. However, interfacial thermal resistance between individual CNT significantly hinders the further improvement in thermal conductivity of CNT‐reinforced nanocomposites. Herein, an interfacial welding strategy is reported to construct graphitic structure welded CNT (GS‐w‐CNT) networks. Notably, the obtained GS‐w‐CNT/polydimethylsiloxane (PDMS) nanocomposite with a GS loading of 4.75 wt% preserves a high thermal conductivity of 5.58 W m−1 K−1 with a 410% enhancement as compared to a pure CNT/PDMS nanocomposite. Molecular dynamics simulations are utilized to elucidate the effect of interfacial welding on the heat transfer behavior, revealing that the GS welding degree plays an important role in reducing both phonon scattering in the GS‐w‐CNT structure and interfacial thermal resistance at the interfaces between CNT. The unique welding strategy provides a new route to optimize the thermal transport performance in filler reinforced polymer nanocomposites, promoting their applications in next‐generation microelectronic devices.
Enhancing Bone Regeneration through CDC20‐Loaded ZIF‐8 Nanoparticles Wrapped in Erythrocyte Membranes with Targeting Aptamer
Authors: Du Yangge , Deng Tian , Cheng Yihong , Zhao Qin , Xia Haibin , Ji Yaoting , Zhang Yufeng , He Qing 
Published: November 2023

AbstractIn the context of bone regeneration, nanoparticles harboring osteogenic factors have emerged as pivotal agents for modulating the differentiation fate of stem cells. However, persistent challenges surrounding biocompatibility, loading efficiency, and precise targeting ability warrant innovative solution. In this study, a novel nanoparticle platform founded upon the zeolitic imidazolate framework‐8 (ZIF‐8) is introduced. This new design, CDC20@ZIF‐8@eM‐Apt, involves the envelopment of ZIF‐8 within an erythrocyte membrane (eM) cloak, and is coupled with a targeting aptamer. ZIF‐8, distinguished by its porosity, biocompatibility, and robust cargo transport capabilities, constitutes the core framework. Cell division cycle protein 20 homolog (CDC20) is illuminated as a new target in bone regeneration. The eM plays a dual role in maintaining nanoparticle stability and facilitating fusion with target cell membranes, while the aptamer orchestrates the specific recruitment of bone marrow mesenchymal stem cells (BMSCs) within bone defect sites. Significantly, CDC20@ZIF‐8@eM‐Apt amplifies osteogenic differentiation of BMSCs via the inhibition of NF‐κB p65, and concurrently catalyzes bone regeneration in two bone defect models. Consequently, CDC20@ZIF‐8@eM‐Apt introduces a pioneering strategy for tackling bone defects and associated maladies, opening novel avenues in therapeutic intervention.
Surface‐Guided Crystallization of Xanthine Derivatives for Optical Metamaterial Applications
Authors: Niazov‐Elkan Angelica , Shepelenko Margarita , Alus Lotem , Kazes Miri , Houben Lothar , Rechav Katya , Leitus Gregory , Kossoy Anna , Feldman Yishay , Kronik Leeor , Vekilov Peter G. , Oron Dan 
Published: November 2023

AbstractNumerous bio‐organisms employ template‐assisted crystallization of molecular solids to yield crystal morphologies with unique optical properties that are difficult to reproduce synthetically. Here, a facile procedure is presented to deposit bio‐inspired birefringent crystals of xanthine derivatives on a template of single‐crystal quartz. Crystalline sheets that are several millimeters in length, several hundred micrometers in width, and 300–600 nm thick, are obtained. The crystal sheets are characterized with a well‐defined orientation both in and out of the substrate plane, giving rise to high optical anisotropy in the plane parallel to the quartz surface, with a refractive index difference Δn ≈ 0.25 and a refractive index along the slow axis of n ≈ 1.7. It is further shown that patterning of the crystalline stripes with a tailored periodic grating leads to a thin organic polarization‐dependent diffractive meta‐surface, opening the door to the fabrication of various optical devices from a platform of small‐molecule based organic dielectric crystals.
An Antidehydration Hydrogel Based on Zwitterionic Oligomers for Bioelectronic Interfacing
Authors: He Ke , Cai Pingqiang , Ji Shaobo , Tang Zihan , Fang Zhou , Li Wenlong , Yu Jing , Su Jiangtao , Luo Yifei , Zhang Feilong , Wang Ting , Wang Ming , Wan Changjin , Pan Liang , Ji Baohua , Li Dechang , Chen Xiaodong 
Published: November 2023

AbstractHydrogels are ideal interfacing materials for on‐skin healthcare devices, yet their susceptibility to dehydration hinders their practical use. While incorporating hygroscopic metal salts can prevent dehydration and maintain ionic conductivity, concerns arise regarding metal toxicity due to the passage of small ions through the skin barrier. Herein, an antidehydration hydrogel enabled by the incorporation of zwitterionic oligomers into its network is reported. This hydrogel exhibits exceptional water retention properties, maintaining ≈88% of its weight at 40% relative humidity, 25 °C for 50 days and about 84% after being heated at 50 °C for 3 h. Crucially, the molecular weight design of the embedded oligomers prevents their penetration into the epidermis, as evidenced by experimental and molecular simulation results. The hydrogel allows stable signal acquisition in electrophysiological monitoring of humans and plants under low‐humidity conditions. This research provides a promising strategy for the development of epidermis‐safe and biocompatible antidehydration hydrogel interfaces for on‐skin devices.
Preventing Dissolution of Cathode Active Materials by Ion‐anchoring Zeolite‐based Separators for Durable Aqueous Zinc Batteries**
Authors: Qin Yao , Wang Xin 
Published: November 2023

AbstractAqueous zinc batteries have emerged as promising energy storage devices due to their safety and low cost. However, they face challenges such as anodic dendrite formation and cathodic compound dissolution. Here, we present the development of a polymer‐matrixed zeolite separator (SZ) by synthesizing zeolite materials on a flexible polymeric membrane. This separator acts as an effective ionic barrier, preventing the leaching and shuttling of vanadium from the cathode, while significantly inhibiting the formation of by‐products and zinc dendrites. The SZ cells demonstrate stable operation for more than 400 cycles at 0.5 A g−1, with an initial capacity of 375.4 mAh g−1, and over 10,000 cycles at 15 A g−1. Notably, when pre‐anchored with vanadium ions, the SZ‐V cells exhibited excellent capacity retention of up to 94.6 % over 1000 cycles. The SZ separator featuring an ion barrier represents a crucial advancement towards the commercialization of zinc storage devices.
In Situ Vaccination with An Injectable Nucleic Acid Hydrogel for Synergistic Cancer Immunotherapy
Authors: Wang Fujun , Xie Miao , Huang Yangyang , Liu Yuhe , Liu Xinlong , Zhu Lijuan , Zhu Xinyuan , Guo Yuanyuan , Zhang Chuan 
Published: November 2023

AbstractRecently, therapeutic cancer vaccines have emerged as promising candidates for cancer immunotherapy. Nevertheless, their efficacies are frequently impeded by challenges including inadequate antigen encapsulation, insufficient immune activation, and immunosuppressive tumor microenvironment. Herein, we report a three‐in‐one hydrogel assembled by nucleic acids (NAs) that can serve as a vaccine to in situ trigger strong immune response against cancer. Through site‐specifically grafting the chemodrug, 7‐ethyl‐10‐hydroxycamptothecin (also known as SN38), onto three component phosphorothioate (PS) DNA strands, a Y‐shaped motif (Y‐motif) with sticky ends is self‐assembled, at one terminus of which an unmethylated cytosine‐phosphate‐guanine (CpG) segment is introduced as an immune agonist. Thereafter, programmed cell death ligand‐1 (PD‐L1) siRNA that performs as immune checkpoint inhibitor is designed as a crosslinker to assemble with the CpG‐ and SN38‐containing Y‐motif, resulting in the formation of final NA hydrogel vaccine. With three functional agents inside, the hydrogel can remarkably induce the immunogenic cell death to enhance the antigen presentation, promoting the dendritic cell maturation and effector T lymphocyte infiltration, as well as relieving the immunosuppressive tumor environment. When inoculated twice at tumor sites, the vaccine demonstrates a substantial antitumor effect in melanoma mouse model, proving its potential as a general platform for synergistic cancer immunotherapy.