bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood Deprivation and DNA Methylation and Expression of Cancer Genes in Breast Tumors
Authors: Jenkins Brittany D. , Rossi Emily , Pichardo Catherine , Wooten William , Pichardo Margaret , Tang Wei , Dorsey Tiffany H. , Ajao Anuoluwapo , Hutchison Ruby , Moubadder Leah , McCullough Lauren E. , Bailey-Whyte Maeve , Ambs Stefan 
Published: November 2023

ImportanceThe biological processes that underlie the association of neighborhood environment with chronic diseases, such as cancer, remain poorly understood.ObjectiveTo determine whether differences in breast tissue DNA methylation are associated with neighborhood deprivation among Black and White women with breast cancer.Design, Setting, and ParticipantsThis cross-sectional study collected breast tissue from women undergoing surgery for breast cancer between January 1, 1993, and December 31, 2003. Participants were recruited through the University of Maryland Medical Center, with additional collection sites at Baltimore-area hospitals. Data analysis was performed from March 1 through December 1, 2022.ExposureYear 2000 census tract–level socioeconomic deprivation measured via neighborhood deprivation index (NDI) as a standardized score, with Black and White race being ascertained through self-report.Main Outcome and MeasuresThe primary outcome was tissue DNA methylation using genome-wide measurements. The secondary outcome was tissue gene expression.ResultsParticipants included 185 women with breast cancer (110 Black [59.5%], 75 White [40.5%]). Mean (SD) age at surgery was 56.0 (14.1) years. Neighborhood deprivation was higher for Black women than for White women (Mean [SD] NDI, 2.96 [3.03] for Black women and −0.54 [1.91] for White women; difference, −3.50; 95% CI, −4.22 to −2.79; P &amp;lt; .001). In unstratified analysis, 8 hypomethylated CpG sites were identified as associated with the NDI, including sites in 2 tumor suppressor genes, LRIG1 and WWOX. Moreover, expression of the 2 genes inversely correlated with neighborhood deprivation. In the race-stratified analysis, the negative correlation between the LRIG1 gene body CpG site cg26131019 and the NDI remained significant in Black women. A neighborhood deprivation–associated decrease in gene expression was also observed for LRIG1 and WWOX in tumors from Black women.Conclusions and RelevanceIn this study, high neighborhood deprivation was associated with differences in tissue DNA methylation and gene expression among Black women. These findings suggest that continued investment in public health interventions and policy changes at the neighborhood level may help to remedy biological alterations that could make minoritized populations more susceptible to chronic diseases.
Predictors of mTICI 2c/3 over 2b in patients successfully recanalized with mechanical thrombectomy
Authors: Wang Richard , Huang Jing , Mohseni Alireza , Hoseinyazdi Meisam , Kotha Apoorva , Hamam Omar , Gudenkauf Julie , Heo Hye Young , Nabi Mehreen , Huang Judy , Gonzalez Fernando , Ansari Golnoosh , Radmard Mahla , Luna Licia , Caplan Justin , Xu Risheng , Yedavalli Vivek 
Published: November 2023

AbstractObjectiveFor patients presenting with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO), mechanical thrombectomy (MT) is the treatment standard of care in eligible patients. Modified Thrombolysis in Cerebral Infarction (mTICI) grades of 2b, 2c, and 3 are all considered successful reperfusion; however, recent studies have shown achieving mTICI 2c/3 leads to better outcomes than mTICI 2b. This study aims to investigate whether any baseline preprocedural or periprocedural parameters are predictive of achieving mTICI 2c/3 in successfully recanalized LVO patients.MethodsWe conducted a retrospective multicenter cohort study of consecutive patients presenting with AIS caused by a LVO from 1 January 2017 to 1 January 2023. Baseline and procedural data were collected through chart review. Univariate and multivariate analysis were applied to determine significant predictors of mTICI 2c/3.ResultsA total of 216 patients were included in the study, with 159 (73.6%) achieving mTICI 2c/3 recanalization and 57 (26.4%) achieving mTICI 2b recanalization. We found that a higher groin puncture to first pass time (OR = 0.976, 95%CI: 0.960–0.992, p = 0.004), a higher first pass to recanalization time (OR = 0.985, 95%CI: 0.972–0.998, p = 0.029), a higher admission NIHSS (OR = 0.949, 95%CI: 0.904–0.995, p = 0.031), and a lower age (OR = 1.032, 95%CI: 1.01–1.055, p = 0.005) were associated with a decreased probability of achieving mTICI 2c/3.InterpretationA lower groin puncture to first pass time, a lower first pass to recanalization time, a lower admission NIHSS, and a higher age were independent predictors of mTICI 2c/3 recanalization.
Hardware Implementation of Network Connectivity Relationships Using 2D hBN‐Based Artificial Neuron and Synaptic Devices
Authors: Jo Yooyeon , Woo Dong Yeon , Noh Gichang , Park Eunpyo , Kim Min Jee , Sung Yong Woo , Lee Dae Kyu , Park Jongkil , Kim Jaewook , Jeong YeonJoo , Lee Suyoun , Kim Inho , Park Jong‐Keuk , Park Seongsik , Kwak Joon Young 
Published: November 2023

AbstractBrain‐inspired neuromorphic computing has been developed as a potential candidate for solving the von Neumann bottleneck of traditional computing systems. 2D materials‐based memristors have been exponentially investigated as promising building blocks of neuromorphic computing because of their excellent electrical performance, simple structure, and small device scale. However, while many researchers have focused on looking into individual artificial neuromorphic devices based on memristors, only few studies on the integration of artificial neuron and synaptic devices have been reported. In this work, both volatile and nonvolatile memristors are fabricated by using a 2D hexagonal boron nitride film for artificial neuron and synaptic devices, respectively. The leaky‐integrate‐and‐fire neuron performance and synaptic functions (e.g., synaptic weight plasticity and spike‐timing‐dependent plasticity) are well emulated with the fabricated volatile and nonvolatile devices. The MNIST image classification is conducted based on the experimental data. For the first time, an artificial neuron‐synapse‐neuron neural network is physically constructed using the artificial neuron and synaptic devices to mimic the biological neural networks. The synaptic connection strength modulation is experimentally demonstrated between the neurons depending on the conductance state of the synapse, paving the way for the development of large‐scale neural network hardware.
Ultrathin Co0.5NiS Nanosheets for Hydrazine Oxidation Assisted Nitrite Reduction
Authors: Wang Xiao‐Hui , Yuan Rou , Yin Shi‐Bin , Hong Qing‐Ling , Zhai Quan‐Guo , Jiang Yu‐Cheng , Chen Yu , Li Shu‐Ni 
Published: November 2023

AbstractNitrite (NO2−) and hydrazine (N2H4) are common N‐pollutants in groundwater. The electrochemical method can realize the treatment of N‐pollutants and the synthesis of energy substance ammonia (NH3). Designing and synthesizing efficient electrocatalysts is of great significance. Herein, ultrathin Co0.5NiS nanosheets attached on nickel foam (Co0.5NiS‐NSs/NF) are synthesized via cyanogel‐NaBH4 hydrolysis process and succedent sulfurization approach. Owing to the ultrathin nanosheet structure and the interaction between Ni and Co, Co0.5NiS‐NSs/NF exhibits high activity for NO2− reduction reaction (NO2−RR), in which the Faraday efficiency is 92.2% and the NH3 yield is 0.25 mmol h−1 cm−2 at −0.15 V potential. Meanwhile, Co0.5NiS‐NSs/NF also displays remarkable activity for N2H4 oxidation reaction in KOH electrolyte. Therefore, a symmetrical Co0.5NiS‐NSs/NF||Co0.5NiS‐NSs/NF electrolyzer is assembled, which only needs the operating voltage of 0.36 V to reach 10 mA cm−2 for NO2−‐to‐NH3 conversion in the presence of N2H4. This work reports a promising and efficient strategy for NH3 production at a small operating voltage and treatment of the N‐pollutants.
Light‐Induced Adaptive Structural Evolution in Gallium Nitride Nanowire/Nickel Hydroxide Symbiotic System in Photoelectrochemical Environment
Authors: Kang Yang , Wang Danhao , Wang Anyang , Chen Wei , Liu Boyang , Fang Shi , Liu Xin , Li Liuan , Ge Binghui , Liu Zhenghui , Zuo Chengjie , Fu Lan , Guo Yuzheng , Liang Kang , Liu Sheng , Sun Haiding 
Published: November 2023

AbstractThe adaptability of living organisms to dynamically adjust their biological behavior in response to fluctuating surroundings is a prerequisite for their evolutionary success. However, artificially‐synthesized materials, especially semiconductors, have not been able to replicate such adaptability due to their inherent physical rigidity and lack of intrinsic structural responsiveness to external stimuli. Herein, an adaptive structural evolution in group‐III‐nitride semiconductors is demonstrated by constructing an AlGaN‐nanowire/Ni(OH)2 symbiotic‐system, resulting in self‐improved optoelectronic characteristics. The mutualistic interplay between AlGaN and Ni(OH)2 nanostructure leads to the adaptive evolution of crystalline‐facets of AlGaN‐nanowires, along with self‐optimization of Ni(OH)2 nanocrystals upon photon‐irradiation during its operation. Specifically, the nanowire‐surfaces dynamically evolve during Ni(OH)2 photo‐deposition, removing the (000) plane while exposing the (10), which facilitates carrier transport at AlGaN/Ni(OH)2 interface. Moreover, light‐induced electrons generated from AlGaN‐nanowires then partially reduce Ni2+ ions in the Ni(OH)2 nanostructure into Ni0 nanometals, which further boosts the proton reduction thermodynamics, generating an unusual self‐improving photocurrent from −59.6 to −101.6 µA cm−2. Such a “symbiotic system,” which is barely observed in conventional semiconductors, provides a promising avenue toward realizing smart adaptive semiconductors that are capable of dynamic structural evolution to fully unleash their potential for emerging optoelectronic and artificial‐photocatalysis applications.
Active Osteoblasts or Quiescent Bone Lining Cells? Preosteoblasts Fate Orchestrated by Curvature and Stiffness of an In Vitro 2.5D Biomimetic Culture System
Authors: Ozanne Hélène , Moubri Loïc , Abou‐Nassif Léa , Thoumire Olivier , Echalard Aline , Morin‐Grognet Sandrine , Atmani Hassan , Ladam Guy , Labat Béatrice 
Published: November 2023

AbstractBiomimetic cell culture systems are required to provide more physiologically relevant microenvironments for bone cells. Here, a simple 2.5D culture platform is proposed, combining adjustable stiffness and surface features that mimic bone topography by using sandpaper grits as master molds with two stiffness formulations of polydimethylsiloxane (PDMS). The subsequent replicas perfectly conform the grits and reproduce the corresponding negative relief with cavities separated by convex edges. Biomimicry is also provided by an extracellular matrix (ECM)‐like thin film coating, using the layer‐by‐layer (LbL) method. The topographical features, alternating concave, and convex structures drive preosteoblasts organization and morphology. Strikingly, curvature orchestrates the commitment of preosteoblasts, with i) maturation to active osteoblasts able to produce a dense collagenous matrix that ultimately mineralizes in the cavities, and ii) edges hosting quiescent cells that synthetize a very thin immature collagen layer with no mineralization. In summary, the present in vitro culture system model offers a cell‐instructive 2.5D microenvironment that controls preosteoblasts fate, leading to two coexisting subpopulations: mature osteoblasts and bone lining cells (BLC). This promising culture system opens new avenues to advanced tissue‐engineered modeling and can be applied to precellularized bone biomaterials.
A Tailored Interface Design for Anode‐Free Solid‐State Batteries
Authors: Wen Jiayun , Wang Tengrui , Wang Chao , Dai Yiming , Song Zhenyou , Liu Xuyang , Yu Qian , Zheng Xueying , Ma Jiwei , Luo Wei , Huang Yunhui 
Published: November 2023

AbstractAnode‐free solid‐state batteries (AFSSBs) are considered to be one of the most promising high‐safety and high‐energy storage systems. However, low Coulombic efficiency stemming from severe deterioration on solid electrolyte/current collector (Cu foil) interface and undesirable Li dendrite growth impede their practical application, especially when rigid garnet electrolyte is used. Here, an interfacial engineering strategy between garnet electrolyte and Cu foil is introduced for stable and highly efficient AFSSBs. By utilizing the high Li ion conductivity of LiC6 layer, interfacial self‐adaption ability arising from ductile lithiated polyacrylic acid polymer layer and regulated Li deposition via Li‐Ag alloying reaction, the garnet‐based AFSSB delivers a stable long‐term operation. Additionally, when combined with a commercial LiCoO2 cathode (3.1 mAh cm−2), the cell also exhibits an outstanding capacity retention due to the tailored interface design. The strategies for novel AFSSBs architecture thus offer an alternative route to design next‐generation batteries with high safety and high density.
Supra‐Photothermal CO2 Methanation over Greenhouse‐Like Plasmonic Superstructures of Ultrasmall Cobalt Nanoparticles
Authors: Cai Mujin , Li Chaoran , An Xingda , Zhong Biqing , Zhou Yuxuan , Feng Kun , Wang Shenghua , Zhang Chengcheng , Xiao Mengqi , Wu Zhiyi , He Jiari , Wu Chunpeng , Shen Jiahui , Zhu Zhijie , Feng Kai , Zhong Jun , He Le 
Published: November 2023

AbstractImproving the solar‐to‐thermal energy conversion efficiency of photothermal nanomaterials at no expense of other physicochemical properties, e.g., the catalytic reactivity of metal nanoparticles, is highly desired for diverse applications but remains a big challenge. Herein, a synergistic strategy is developed for enhanced photothermal conversion by a greenhouse‐like plasmonic superstructure of 4 nm cobalt nanoparticles while maintaining their intrinsic catalytic reactivity. The silica shell plays a key role in retaining the plasmonic superstructures for efficient use of the full solar spectrum, and reducing the heat loss of cobalt nanoparticles via the nano‐greenhouse effect. The optimized plasmonic superstructure catalyst exhibits supra‐photothermal CO2 methanation performance with a record‐high rate of 2.3 mol gCo−1 h−1, close to 100% CH4 selectivity, and desirable catalytic stability. This work reveals the great potential of nanoscale greenhouse effect in enhancing photothermal conversions through the combination with conventional promoting strategies, shedding light on the design of efficient photothermal nanomaterials for demanding applications.
Highly Sensitive Optical Manometer Based on the Visible Emissions of Ce3+‐Doped La6Sr4(SiO4)6F2 Multisite Phosphors
Authors: Szymczak Maja , Du Peng , Runowski Marcin , Woźny Przemyslaw , Xue Junpeng , Zheng Teng , Marciniak Lukasz 
Published: November 2023

AbstractFor overcoming the unsatisfactory sensitivity of optical manometers and the susceptibility of manometric parameters to temperature changes, a series of Ce3+‐doped La6Sr4(SiO4)6F2 phosphors with multicolor emissions are developed. Excited by 375 nm, the resultant compounds exhibit asymmetric and broad emission bands, which can be easily deconvoluted into two peaks originating from seven to ninefold coordinated Ce3+ sites, where their intensities are dependent on the excitation wavelength. Through analyzing the pressure‐related luminescence intensity ratio (LIR) derived from these two Ce3+ sites, it is clear that the final manometer exhibits an unprecedentedly high relative sensitivity of ≈ 425% GPa−1 at 0.76 GPa (the highest value reported to date). As pressure increases, the emitting color tunes from yellow to blue, resulting in the possibility of visual pressure sensing. Furthermore, based on the color coordinates of the phosphor material, its pressure sensing capability is discussed, in which the maximum sensitivities are 24.38 and 27.74% GPa−1 at 0.76 GPa, when x‐coordinate and y‐coordinate are employed, respectively. Additionally, the LIR value is only slightly affected by temperature, leading to a thermal invariability manometric factor (TIMF) > 400 K GPa−1. The findings indicate that Ce3+‐doped La6Sr4(SiO4)6F2 phosphors are good luminescent candidates for optical and visual multi‐mode manometers.
Self‐help/mutual aid groups for health and psychosocial problems: Key features and their perspectives in the 21st century
Authors: Lainas Sotiris 
Published: November 2023

AbstractIn this virtual special issue, a set of 26 papers previously published in the American Journal of Community Psychology (AJCP), focused on self‐help/mutual aid groups (SH/MAGs), are being curated given their significant impact in this domain. SH/MAGs constitute an important component of the community psychology's proposal to address various psychosocial and health problems. The American Journal of Community Psychology has played an important role in exploring the characteristics of self‐help/mutual aid groups in various fields. These articles cover important areas of the study of self‐help/mutual‐aid groups. More specifically, the selected articles address issues such as the definition and key characteristics of self‐help/mutual aid groups, the main fields that are applied, such as mental health, addictions, and disabilities. The article also addresses important issues such as the place of self‐help/mutual aid groups in health systems, the experiential knowledge generated within these groups and the relationship of health professionals with these groups. The aim is this VSI to contribute to contemporary discussion on self‐help/mutual aid groups, their challenges, and their perspectives and to highlight the crucial role that community psychology has in this field.
Phenotypic and proteomic characterization of the human erythroid progenitor continuum reveal dynamic changes in cell cycle and in metabolic pathways
Authors: Papoin Julien , Yan Hongxia , Leduc Marjorie , Le Gall Morgane , Narla Anupama , Palis James , Steiner Laurie A. , Gallagher Patrick G. , Hillyer Christopher D. , Gautier Emilie‐Fleur , Mohandas Narla , Blanc Lionel 
Published: November 2023

AbstractHuman erythropoiesis is a complex process leading to the production of 2.5 million red blood cells per second. Following commitment of hematopoietic stem cells to the erythroid lineage, this process can be divided into three distinct stages: erythroid progenitor differentiation, terminal erythropoiesis, and reticulocyte maturation. We recently resolved the heterogeneity of erythroid progenitors into four different subpopulations termed EP1–EP4. Here, we characterized the growth factor(s) responsiveness of these four progenitor populations in terms of proliferation and differentiation. Using mass spectrometry‐based proteomics on sorted erythroid progenitors, we quantified the absolute expression of ~5500 proteins from EP1 to EP4. Further functional analyses highlighted dynamic changes in cell cycle in these populations with an acceleration of the cell cycle during erythroid progenitor differentiation. The finding that E2F4 expression was increased from EP1 to EP4 is consistent with the noted changes in cell cycle. Finally, our proteomic data suggest that the protein machinery necessary for both oxidative phosphorylation and glycolysis is present in these progenitor cells. Together, our data provide comprehensive insights into growth factor‐dependence of erythroid progenitor proliferation and the proteome of four distinct populations of human erythroid progenitors which will be a useful framework for the study of erythroid disorders.
Delayed presentation of transdermal cyanide poisoning
Authors: Lim J. W. L. , Kwa C. , Loh S. , Yew W. S. 
Published: November 2023

SummaryA 45‐year‐old man attended to a warehouse fire involving burning plastic, without wearing full protective equipment. He subsequently presented to hospital with shortness of breath and his trachea was intubated for airway protection due to initial concerns of inhalational injury. However, a post‐intubation bronchoscopy was normal. The patient's serum lactate level was normal on admission but was increased when measured 14 h after the initial event and accompanied by a metabolic acidosis. Transdermal cyanide poisoning was suspected given this delayed biochemical presentation and the absence of another apparent cause. A handheld chemical detector detected a high level of toxins on the patient's skin. Clinical improvement was not observed after the first dose of intravenous hydroxocobalamin, which was administered before full body decontamination. After decontamination and the administration of a second dose of hydroxocobalamin, the patient's acid–base status rapidly improved and serum lactate level returned to normal. Clinicians should have a high index of suspicion for transdermal cyanide poisoning in patients presenting after exposure to a fire.
Noise reduction and characteristic analysis of fluid signal in the jet impact‐negative pressure deamination reactor based on wavelet transform
Authors: Huang Xiaodie , Zhang Xingzong , Xie Xingjuan , Qiu Facheng 
Published: November 2023

AbstractThe jet impact‐negative pressure deamination reactor (JI‐NPDR) is a new type of continuous and efficient deamination equipment. The study of the random flow pattern of porous jet impingement in the reactor under negative pressure conditions is an important issue. In this work, the signal processing method based on wavelet transform is used to analyze the characteristics of random flow signals in the reactor. Meanwhile, an analog similar signal is built and three sets of Gaussian white noise with various signal‐to‐noise ratios are employed via the MATLAB platform. Based on the adjustment of threshold function, threshold, decomposition level and other parameters of wavelet transform, the noise ratio (SNR) and mean squared error (MSE) are used to evaluate the wavelet denoising effect. And then, the optimal denoising scheme for the obtained signal will be applied in processing the vacuum flow signal collected inside the deamination reactor. Subsequently, the 8‐layer wavelet decomposition is investigated by using sym7 as the wavelet basis, soft threshold function, and heursure threshold for signal denoising. Then, the analog signal is fed back through the results of the actual signal denoising, and the number of wavelet decomposition layers is adjusted from 8 to 9 layers to optimize the original wavelet denoising combination. By analyzing the low‐frequency and high‐frequency parts of the signal spectrum before and after denoising, it was found that wavelet transform can effectively denoise the fluid signal in the reactor.
A DOPO‐based reactive flame retardant containing benzimidazole groups: Synthesis and its flame‐retardation on epoxy resin
Authors: Liu Dongyue , Jiang Feng , Zhang Tianlong , Yu Chunxiao , Hu Zhiyu , Zhang Lei , Shi Shuangyou 
Published: November 2023

AbstractDOPO based flame retardants demonstrate exceptional flame retardancy efficiency when applied to epoxy resins. However, the crosslinking degree of epoxy resin may decrease due to the addition of DOPO, leading to a deterioration in flame retardancy and mechanical properties. Herein, a reactive DOPO derivative flame retardant 6‐((1H‐benzo[d]imidazol‐2‐yl) amino) dibenzo oxaphosphinine 6‐oxide (BADO) was successfully synthesized, which contains multiple reactive sites, thus ensuring a higher degree of crosslinking in the system. As a result, the modified epoxy resin exhibits excellent flame retardancy. The limiting oxygen index value of the modified epoxy resins increased from 19.8% to 29.7% by adding 7.5 wt% BADO, and its UL‐94 test passed V‐0. Flame retardancy mechanism analysis reveals that BADO exhibits both gas‐phase and condensed‐phase flame retardant effects. In particular, the formation of a porous inside‐char layer is a significant factor in reducing smoke release. The 7.5% BADO/EP composite exhibited a 43.2% reduction in total smoke production and a 43.6% reduction in total smoke rate compared to neat epoxy resins (EP). Furthermore, the addition of BADO slightly deteriorates the mechanical properties of the modified epoxy resin.