bluuebunny/crossref_metadata_2025_split huggingface dataset:
INVESTASI MODAL MANUSIA DAN NILAI PERUSAHAAN PUBLIK DI INDONESIA
Authors: Saleh Mustaruddin 
Published: January 2024

Kepedulian perusahaan terhadap pentingnya investasi sumberdaya manusia merupakan landasan bagi perusahaan untuk lebih unggul dan kompetitif. Salah faktor penting yang dipertimbangkan oleh para investor dalam menginvestasikan modalnya untuk membeli saham perusahaan adalah kompentensi sumberdaya manusia dalam perusahaan tersebut. Berinvestasi dalam sumber daya manusia adalah bagian dari strategi perusahaan, yang membekali karyawan dengan keterampilan teoretis dan praktis melalui pelatihan dengan potensi produk akhir peningkatan kinerja. Manfaat jangka panjang dari investasi sumber daya manusia melebihi biaya jangka pendek; manfaat tersebut termasuk peningkatan atribut keberlanjutan dan nilai keuangan. Tujuan dari tulisan ini adalah untuk menunjukkan secara empiris bagaimana pengaruh investasi modal manusia terhadap nilai perusahaan publik di Indonesia. Dengan menggunakan metode purposive sampling terpilih sebanyak 28 perusahaan publik yang terdaftar di indeks LQ45 Bursa Efek Indonesia (BEI) dengan jumlah observasi 196 selama periode 2014 sampai dengan 2020. Hasil uji simultan pada kedua model yang digunakan dalam penelitian dengan menggunakan uji statistik F, menunjukkan bahwa variabel independen yang digunakan pada kedua model mampu menjelaskan nilai perusahaan. Kemampuan dalam menjelaskan dari variabel-variabel yang digunakan dalam kedua model regresi data panel dengan menggunakan uji Adjusted R2 adalah masing-masing sebesar 70.73 persen pada model 1 dan 70,72 persen pada model 1, sedangkan sisanya dijelaskan dari variabel lain yang tidak digunakan dalam penelitian ini. Hasil uji parsial dengan menggunakan uji statistis t, bahwa variabel BPAU yang digunakan untk mengukur persentasi biaya pengembangan karyawan terhadap biaya administrasi dan umum berpengaruh negatif signifikan terhadap nilai perusahaan pada kedua model. Pengujian partial least squares (PLS) menggungkapkan bahwa (BPAU) dapat memoderasi variabel profitabilitas, ukuran perusahaan dan tingkat leverage yang digunakan terhadap nilai perusahaan yang diukur dengan variabel PBV. Hasil pengujian statistik di atas memberikan informasi yang berharga bagi semua pihak, bahwa dengan pengeluaran dana pengembangan karyawan yang berdampak negatif terhadap nilai perusahaan, mengidentifikasikan bahwa kepedulian para pihak terhadap pengembangan karyawan sebagai asset penting bagi perusahaan belum sepenuhnya mendapatkan apresiasi.
ANALISIS RESIKO KECELAKAAN KERJA DI BENGKEL PT. XYZ DENGAN METODE FAILURE MODE AND EFFECT ANALYSIS
Authors: Imawan Bagas , Priyana Efta Dhartikasari , Nugroho Yanuar Pandu 
Published: January 2024

PT. XYZ merupakan perusahaan dengan berfokus pada sektor jasa transportasi pengangkutan barang dengan pendirian di Surabaya. Melalui terjadinya peningkatan permintaan pelanggan pada jasa pengankutan barang. Dalam observasi awal yang dilaksanakan peneliti ada sejumlah kecelakaan kerja yang dialami pekerja saat proses kerja berlangsung dimana penyebab dari kecelakaan kerja itu dikarenakan atas lingkungan, mesin, manusia, metode, beserta material dengan tidak baik atau tidak layak digunakan. Penelitian ini bertujuan untuk mengetahui identifikasi risiko kecelakaan kerja yang bisa mempengaruhi pekerja di PT. XYZ. Penelitian ini juga menggabungkan dua metode yakni metode Failure Mode and Effect Analysis (FMEA) beserta diagram Fishbone. Hasil dari penelitian ini memiliki 7 kegagalan berisiko dari 11 kejadian dalam perusahaan PT. XYZ, dengan hasil tertinggi perhitungan RPN (risk priority number) sebesar 71,94 persen dengan faktor kegagalan perbaikan piston truk dengan risiko tangan mengalami terjepit dengan penyebab tidak memakai alat pelindung ketika melakukan perbaikan piston dengan solusi Perhatikan posisi jari, tangan maupun bagian tubuh lainnyadiantara objek apa saja.
Community Compliance with Health Regulations during the COVID-19 Pandemic
Authors: Yulianita Henny , Priladani Dhea Shobriana , Setyorini Dyah , Sugiharto Firman , Somantri Irman , Eriyani Theresia , Komariah Maria 
Published: January 2024

Aim: This study aimed to describe of community compliance in implementing health regulations during the COVID-19 pandemic in the Panyileukan subdistrict, Bandung, West Java, Indonesia.
Method: The study was quantitative descriptive research. The study population was residents who live Panyileukan District (N=242). The sampling technique used was purposive sampling (n=77). Data were collected using the modified self-report questionnaire regarding adherence in implementing health protocol which were valid and reliable. Data were analyzed using descriptive statistics and presented in frequency distribution tables and diagrams.
Results: The results show that more than half of the respondents (56%) complied with the health regulations. The indicators show that 55.8% wore masks, 53.2% washed hands, 62.3% maintained social distance, and 54.5% increased their immune systems. Regarding the response dimensions, 63.6 % of respondents believed in the regulations, 55.8% accepted the regulation, and 51.9% applied the regulations.
Conclusions: Most people in the Panyileukan subdistrict adhered to the health protocols. Local governments and health workers could continue facilitating, motivating, and monitoring compliance.
The three-dimensional culture of L929 and C2C12 cells based on SPI-SA interpenetrating network hydrogel scaffold with excellent mechanical properties
Authors: Ma Chunmin , Gao Xinru , Yang Yang , Bian Xin , Wang Bing , Liu Xiaofei , Wang Yan , Su Dan , Zhang Guang , Qu Lizhe , Zhang Na 
Published: January 2024

Cell-cultured meat, which is obtained by adsorbing cells on the three-dimensional scaffold, is considered a potential solution to animal welfare issues. Edible and safe cell-cultured meat scaffolds are a key part of its research. Soy protein isolate (SPI) hydrogel has a three-dimensional network structure and has been studied for L929 cell culture because of its non-toxicity and biocompatibility. However, the toughness and mechanical properties of SPI hydrogel are not enough to bear the requirements of cell cultivation. In this paper, sodium alginate (SA) was added to SPI hydrogel, and the interpenetrating network (IPN) technology was used to construct SPI-SA IPN hydrogel by transglutaminase and Ca2+ double crosslinking method. SPI-SA IPN hydrogel has excellent mechanical properties, structural stability and biodegradable performance than SPI hydrogel. The bio-compatibility and degradability of L929 and C2C12 cells on SPI-SA IPN hydrogel were studied by cytotoxicity, trypan blue and living/dead cell staining, and the growth law of the hydrogel as a scaffold for cell culture was analyzed. The results showed that L929/C2C12 cells can proliferate normally and adhere in hydrogel and have good bio-compatibility. L929 cells with size about 20–50 µm have better adhesion and growth abilities on SPI-SA IPN hydrogel than C2C12 cells with 100–300 µm. Therefore, the SPI-SA IPN hydrogel is non-toxic and supports the growth of cells in the pores of the material. This study provides a reference for the application of SPI-SA IPN hydrogels in vitro cell growth.
Antibiofilm peptides enhance the corrosion resistance of titanium in the presence of Streptococcus mutans
Authors: Wang Dan , Yue Yingying , Liu He , Zhang Tian , Haney Evan F. , Hancock Robert E. W. , Yu Jian , Shen Ya 
Published: January 2024

Titanium alloys have gained popularity in implant dentistry for the restoration of missing teeth and related hard tissues because of their biocompatibility and enhanced strength. However, titanium corrosion and infection caused by microbial biofilms remains a significant clinical challenge leading to implant failure. This study aimed to evaluate the effectiveness of antibiofilm peptides 1018 and DJK-5 on the corrosion resistance of titanium in the presence of Streptococcus mutans. Commercially pure titanium disks were prepared and used to form biofilms. The disks were randomly assigned to different treatment groups (exposed to S. mutans supplied with sucrose) including a positive control with untreated biofilms, peptides 1018 or DJK-5 at concentrations of 5 μg/mL or 10 μg/mL, and a negative control with no S. mutans. Dynamic biofilm growth and pH variation of all disks were measured after one or two treatment periods of 48 h. After incubation, the dead bacterial proportion, surface morphology, and electrochemical behaviors of the disks were determined. The results showed that peptides 1018 and DJK-5 exhibited significantly higher dead bacterial proportions than the positive control group in a concentration dependent manner (p &lt; 0.01), as well as far less defects in microstructure. DJK-5 at 10 μg/mL killed 84.82% of biofilms and inhibited biofilm growth, preventing acidification due to S. mutans and maintaining a neutral pH. Potential polarization and electrochemical impedance spectroscopy data revealed that both peptides significantly reduced the corrosion and passive currents on titanium compared to titanium surfaces with untreated biofilms, and increased the resistance of the passive film (p &lt; 0.05), with 10 μg/mL of DJK-5 achieving the greatest effect. These findings demonstrated that antibiofilm peptides are effective in promoting corrosion resistance of titanium against S. mutans, suggesting a promising strategy to enhance the stability of dental implants by endowing them with antibiofilm and anticorrosion properties.
InSAR coseismic deformation field and seismogenic structure of the 2020 Mw6.0 Jiashi earthquake and the implication for the moderate-magnitude seismicity in the southwestern Tian Shan, western China
Authors: Wu Danruo , Chen Zhidan , Zimin Mikhail 
Published: January 2024

The Kepingtage fold-and-thrust belt in the southwestern Tian Shan in western China hosted the 2020 Mw 6.0 Jiashi earthquake with no apparent surface ruptures. The thrust nappe structure in this region is characterized by moderate-magnitude (Mw5.5-6.5) seismicity, but the seismogenic mechanisms and controlling factors remain under investigation. In this study, we utilized Sentinel-1A synthetic aperture radar satellite data to reconstruct the InSAR coseismic deformation field of the 2020 Jiashi earthquake. To address the limitation imposed by residual orbital phases during the interferometric measurement, we proposed a novel automatic method that combines ascending and descending track data with terrain features for orbit refinement. Eight comparative tests were conducted to prove the effectiveness of the proposed method. Subsequently, we inverted the jointly constrained deformation field after orbit correction to obtain the fault geometric parameters and slip distribution. Our results show that the 2020 Jiashi earthquake is characterized by right-lateral transpressive motion. The smooth interference fringes demonstrate spatially continuous surface uplift and subsidence without detectable coseismic surface ruptures, with a maximum uplift of ∼0.08 m and a maximum subsidence of ∼0.03 m, caused by the subsurface folding due to deep seismic rupture. This event is best fitted by a north-dipping fault plane with a depth of 4.2 km, a dip angle of 11.6°, and a strike of 276° beneath the Keping thrust fault. In terms of various geometric parameters of the fault, the inversion results of this study are generally similar to the focal mechanism solution provided by USGS (MWb), but are different from the focal mechanism solutions of other institutions and previous research results. Combined with the published geological investigations and seismic reflection surveys, we suggest that the seismogenic structure of the 2020 Jiashi earthquake is the lower ramp of the Keping thrust fault and the abrupt fault bend between the lower and upper ramp may limit the propagation of the coseismic rupture to the surface. The limited rupture of this event is dominated by the irregularities in fault geometry along strike and dip, as well as the lower rock strength of the cover above the detachment, which contribute to a deeper understanding of the seismic behavior in fold-and-thrust belts and the moderate-magnitude seismicity in the southwestern Tian Shan region.
Large-eddy simulation of the effects of horizontal and vertical adjustments in a wind farm
Authors: Zhao Dandan , Xin Jinyuan , Pan Xiaole , Ma Yongjing , Ren Xinbing , Jiang Yunyan , Ma Yining , Gong Chongshui 
Published: January 2024

In order to study the fine structural characteristics of the wind field and wind power generation in wind farms, large-eddy simulations (LES) with different layouts are carried out under a given wind direction. In the simulation, a single wind turbine can produce a wake effect, reducing the wind within 2 km by 50%, and the influence between wind turbines gradually decreases as the distance between the wind turbines increases. To minimize the impact of the wake effect between the turbines, the simulation considering horizontal and vertical staggering of the wind farm is conducted. Under the prevailing wind, the optimal power output for the entire wind farm is obtained when a horizontal staggering degree θ of 16.7 is used and no vertical staggering is adapted. Unexpectedly, vertical interleaving hardly increases power generation in terms of the whole wind farm. This research result has certain implications for the optimal layout of wind farms in practical applications, especially in sites with a well-defined prevailing wind direction.
Reduced mitochondrial respiration in peripheral T cells after paediatric heamatopoietic stem cell transplantation
Authors: Mølgaard Kasper , Kielsen Katrine , Ifversen Marianne , Met Özcan , Svane Inge Marie , Müller Klaus 
Published: January 2024

BackgroundRecovery and functional differentiation of T-cell subsets are central for the development of immune function and complications after allogeneic hematopoietic stem cell transplantation (HSCT), but little is known about the cellular respiration and factors influencing T-cell metabolic fitness during immune maturation after HSCT.MethodWe included 20 HSCT patients and analysed mitochondrial oxidative phosphorylation and mitochondrial fitness in peripheral blood mononuclear cell samples collected at days +90 and +180 after HSCT.ResultsPhenotypic analysis revealed lower overall T-cell counts, lower CD4+/CD8+ ratio and a skewed distribution of early T-cell subsets at day +90, gradually recovering by day +180. Although ATP turnover in HSCT patients was similar to healthy controls, the spare respiratory capacity (SRC) of T cells, reflecting the available energy reserve, was significantly reduced at day +90 and +180 compared to healthy controls. This reduction in SRC was not correlated with the occurrence of acute graft-versus-host disease (aGVHD), the intensity of conditioning regimens and markers of T-cell exhaustion.ConclusionWe found significantly depressed SRC until six months post-HSCT, but we were not able to identify transplant-related risk factors or associations with the clinical outcome.
Visit-to-visit variability in blood pressure and the risk of open-angle glaucoma in individuals without systemic hypertension: a nationwide population-based cohort study
Authors: Lee Sang Yeop , Lee Ji Sung , Kim Jae Yong , Tchah Hungwon , Lee Hun 
Published: January 2024

PurposeWe aimed to evaluate the effect of visit-to-visit variability in blood pressure (BP) on the risk of open-angle glaucoma (OAG) in individuals without systemic hypertension using a population-based retrospective cohort study design.MethodsThe Korean National Health Insurance Service-National Health Screening Cohort database, which collected data of 209,226 individuals between 2002 and 2015, was used to analyze the data of 140,910 eligible participants. The mean follow-up duration was 8.3 years. Visit-to-visit BP variability was assessed using standard deviation (SD), coefficient of variation (CV), and variability independent of the mean (VIM). Participants were categorized into four groups according to BP variability quartiles. We verified the effect of BP variability by comparing participants of the first to third quartiles of BP variability groups with those belonging to the fourth quartile group. A Cox proportional hazards model was used to determine the hazard ratio (HR) of BP variability in cases of newly diagnosed OAG. Moreover, we conducted subgroup analyses using baseline characteristics.ResultsIn the multivariable analyses, BP variability did not significantly increase the risk of OAG development. However, subgroup analyses revealed significant interactions between age and systolic BP variability in the development of OAG (CV: p = 0.008; SD: p = 0.007). For participants aged &lt;60 years, the risk of OAG development significantly increased with high systolic BP variability (CV: HR, 1.18; 95% confidence interval [CI], 1.00–1.39; p = 0.049). We observed a similar trend using the SD and VIM as the parameters for systolic BP variability.ConclusionHigher visit-to-visit systolic BP variability was associated with an increased risk of OAG development in participants younger than 60 years of age without systemic hypertension. These results suggest that BP variability can be the considerable factor when assessing the risk of OAG, especially in relatively young people without systemic hypertension.
Construction of shared gene signature between rheumatoid arthritis and lung adenocarcinoma helps to predict the prognosis and tumor microenvironment of the LUAD patients
Authors: Shi Liping , Zou Houwen , Yi Jian 
Published: January 2024

Introduction: Rheumatoid arthritis (RA) is a common chronic autoimmune disease with high incidence rate and high disability rate. One of the top complications is cancer, especially lung adenocarcinoma (LUAD). However, the molecular mechanisms linking RA and LUAD are still not clear. Therefore, in this study, we tried to identify the shared genetic signatures and local immune microenvironment between RA and LUAD and construct a clinical model for survival prediction.Methods: We obtained gene expression profiles and clinical information of patients with RA and LUAD from GEO and TCGA datasets. We performed differential analysis and Weighted Gene Co-expression Network Analysis (WGCNA) to discover the shared genes between RA and LUAD. Then, COX regression and LASSO analysis were employed to figure out genes significantly associated with survival. qRT-PCR and Western blot were utilized to validate the expression level of candidate genes. For clinical application, we constructed a nomogram, and also explored the value of RALUADS in characterizing immune infiltration features by CIBERSORT and xCell. Finally, responses to different drug therapy were predicted according to different RALUADS.Results: Our analysis identified two gene sets from differentially expressed genes and WGCNA gene modules of RA and LUAD. Filtered by survival analysis, three most significant shared genes were selected, CCN6, CDCA4 and ERLIN1, which were all upregulated in tumors and associated with poor prognosis. The three genes constituted RA and LUAD score (RALUADS). Our results demonstrated that RALUADS was higher in tumor patients and predicted poor prognosis in LUAD patients. Clinical nomogram combining RALUADS and other clinicopathological parameters had superior performance in survival prediction (AUC = 0.722). We further explored tumor immune microenvironment (TME) affected by RALUADS and observed RALUADS was closely related to the sensitivity of multiple immune blockades, chemotherapy and targeted drugs.Conclusion: Our findings suggest that there are shared physiopathologic processes and molecular profiles between RA and LUAD. RALUADS represents an excellent prognosis predictor and immune-related biomarker, which can be applied to select potential effective drugs and for LUAD patients with RA.
Autism Spectrum Disorder and collective catering service: results of the pilot study FOOD-AUT
Authors: Conti Maria Vittoria , Santero Sara , Breda Chiara , Basilico Sara , de Filippo Giorgia , Luzzi Alessia , Voto Luana , Cavagnola Rebecca , Tomasinelli Chiara Elena , Cena Hellas 
Published: January 2024

ObjectiveIndividuals with Autism Spectrum Disorder (ASD) often exhibit a low dietary diversity due to food selectivity that leads them to a marked preference for high-energy-density food, exposing them to risk of malnutrition. Despite these aspects, specific recommendations and targeted menus for this population are missing. The pilot study FOOD-AUT addresses this issue by developing canteen menus meeting the nutritional and sensory needs of adults with ASD, aiming to reduce their food selectivity, and consequently improving their health.MethodsThe project, funded by Gruppo Pellegrini S.p.A, was conducted at the daycare service of Sacra Famiglia Onlus Foundation, between March-2022 to March-2023. The study was divided into two phases. Observational phase: a comparison was made between the enrolled subjects’ nutritional needs and the nutrient content of the administered menus during the daycare service. Then mealtime compliance was assessed using standardized meal evaluation forms, both quantitative and qualitative. Intervention phase: canteen menus targeted to the individuals’ nutritional and sensory needs were administered and their acceptability was evaluated.ResultsTwenty-two individuals with ASD, aged 19–48, 72.7% males, were enrolled. Overweight and obesity prevalence were 54.5 and 18.2%, respectively. The observational phase showed how the most accepted foods had specific sensorial characteristics in line with the scientific literature. Adapting the menus improved food acceptance and reduced food waste.ConclusionThe results highlighted the need for adapted menus and greater attention to the way meals are delivered and consumed to improve nutritional status and therefore health of this population at increased risk of malnutrition.Clinical trial registrationClinicalTrial.gov, unique identifier: NCT05978895.
Outcomes of olecranon fractures in adolescents: comparison of tension band wiring and Herbert screw fixations
Authors: Yang Weiwei , Zhang Xintao , Sun Dong , Jin Shaobin , Chen Junfei , Li Yang 
Published: January 2024

PurposeOlecranon fracture is considered intra-articular when there is obvious displacement or an irregular articular surface. Such fractures should be reduced and fixed via surgery. No clear indications regarding the surgical technique to be adopted exist. Therefore, this study aimed to compare the outcomes of tension band wiring (TBW) and Herbert screw fixations for olecranon fractures.MethodsWe retrospectively analyzed the clinical data of 29 children with olecranon fractures. They were divided into the tension band wiring and Herbert screw groups. We assessed early epiphyseal closure and maximum length of the ulna using radiography. Patients were clinically evaluated using the average QuickDASH score.ResultsBoth groups had good radiological outcomes. Herbert screws demonstrated advantages in terms of bleeding, operative time, intraoperative blood loss, surgery duration, and particularly the QuickDASH score (1.57 vs. 4.18, p &lt; 0.05). Complications, including needle loosening and bursitis, occurred in five cases in the TBW group. Six cases had premature physis plate closure, and no difference was observed in limb length at 6 months after surgery.ConclusionCompared with TBW, Hebert screws demonstrated better clinical outcomes and lesser postoperative complications in the treatment of ulnar olecranon fractures in children. However, long-term follow-up is required to assess the effects of screws on the ulnar physis plate and ulna length.