bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building Pathology Capacity in Sub-Saharan Africa to Improve Breast Cancer Diagnosis and Treatment: Training Laboratory Technicians in High-quality Manual Immunohistochemistry
Authors: Setiawan Linda , Graef Katy , Schmolze Dan , Alem Alemwosen , Taylor Lesley 
Published: October 2023

Abstract
Background: To address the need for a skilled workforce in breast cancer (BC) pathology in sub-Saharan Africa (SSA), we implemented an education program to train laboratory technicians in manual immunohistochemistry (IHC).
Methods:A cross-sectional quality improvement education project was developed. Interactive webinars were held every six months with didactics and presentations from African experts with experience in IHC. We conducted knowledge assessments and surveys on current practice, equipment, and human resources. A digital mentorship platform (DMP) was created for discussions, sharing SOPs, and networking. For one year (2022-2023), we followed developments in pathology capacity, practice changes, and educational needs.
Results: 266 participants from 10 SSA countries attended the first webinar, a series of six lectures on IHC theory, methods, and practice. 95 participants from nine SSA countries provided a baseline assessment of pathology capacity and feedback. Mean knowledge increased by 17.4% (from 41.8% pre-webinar to 59.2% post, p=<0.0001). Self-reported confidence in topics increased by 11.3% (mean 3.36 pre- to 3.74 post, p=0.1). Over six months, recordings were accessed 412 times. After six months, the second webinar had 93 participants from eight SSA countries. Membership in the DMP increased from 64 to 172; recordings were viewed 412 times in six months; and 113 participants from nine SSA countries completed surveys. Among 74 respondents who perform IHC, 43.5% reported moderate or significant positive practice changes such as improved antigen retrieval techniques and optimization of preanalytical variables. The majority (52.7%, n=39) reported the quality of slides had moderately or significantly improved. After one year, a third webinar had 98 participants from eight SSA countries. Thirty-eight completed surveys, DMP membership increased to 199, and 1 reported launching IHC in a lab in Nigeria.
Conclusions: Our program 1) reached hundreds of participants and provided a baseline assessment of pathology capacity across nine SSA countries; 2) created a novel mechanism to build pathology capacity and assess progress with this cohort; and 3) improved practices and the preparation of slides for the majority performing manual IHC. After one year, interest was sustained. Tracking impact on diagnosis and treatment of BC in the region is needed long-term.
Strength-ductility materials by engineering coherent interface at incoherent precipitates
Authors: Huang Yongxian 
Published: October 2023

Abstract
In the quest for excellent light-structural materials that can withstand mechanical extremes for advanced applications, design and control of microstructures beyond current material design strategy become paramount. Here, we design a coherent spinodal decomposition shell at incoherent precipitates in the 2195 aluminum alloy with multi-step metastable phase transitions. A high local strain rate via a neoteric deformation-driven metallurgy method facilitated the uphill diffusion of Li. The original T1 (Al2CuLi) phases were transformed into coherent-shell (Li-rich) coated incoherent-core (Al2Cu) precipitates. The ultimate tensile strength and elongation reached 620 ± 18MPa and 22.3 ± 2.2%, exhibiting excellent strength-ductility synergy. A new "incoherent-coherent interact" strain-hardening mechanism was clarified, which was believed to be promoted in other heat-treatable alloy systems, especially with multi-step metastable phase transitions.
Salinity-Responsive Histone PTMs Identified in the Gills and Gonads of Mozambique Tilapia (Oreochromis mossambicus)
Authors: Mojica Elizabeth A. , Fu Yuhan , Kültz Dietmar 
Published: October 2023

Abstract

Background
Histone post-translational modifications (PTMs) are epigenetic marks that can be induced by environmental stress and elicit heritable patterns of gene expression. To investigate this process in an ecological context, we characterized the influence of salinity stress on histone PTMs within the gills, kidney, and testes of Mozambique tilapia (Oreochromis mossambicus). A total of 221 histone PTMs were quantified in each tissue sample and compared between freshwater-adapted fish exposed to salinity treatments that varied in intensity and duration.
Results
Four salinity-responsive histone PTMs were identified in this study. When freshwater-adapted fish were exposed to seawater for two hours, the relative abundance of H1K16ub significantly increased in the gills. Long-term salinity stress elicited changes in both the gills and testes. When freshwater-adapted fish were exposed to a pulse of severe salinity stress, where salinity gradually increased from freshwater to a maximum of 82.5 g/kg, the relative abundance of H1S1ac significantly decreased in the gills. Under the same conditions, the relative abundance of both H3K14ac and H3K18ub decreased significantly in the testes of Mozambique tilapia.
Conclusions
This study demonstrates that salinity stress can alter histone PTMs in the gills and gonads of Mozambique tilapia, which, respectively, signify a potential for histone PTMs to be involved in salinity acclimation and adaptation in euryhaline fishes. These results thereby add to a growing body of evidence that epigenetic mechanisms may be involved in such processes.
The association between mental health and participatory sports consumption: A cross-sectional study
Authors: Su Yaqi 
Published: October 2023

Abstract

Background Participatory sports consumption (PSC) can improve mental wellness. However, despite advances in science, technology, and medicine, evidence suggests that our mental health has declined in recent decades. PSC, which is becoming more prevalent in the sports industry, may enhance our sports experience and positively impact mental health. Therefore, studying the relationship between PSC and mental health is important. Methods This study employed the Korea Health Panel Annual Data 2019 data of 11,268 participants aged over 19 years old to evaluate the relationship between PSC and mental health. Adjustments were made for sex, age, education level, household income, and chronic disease. Subgroup analyses were also conducted based on sex, age, and exercise level. Results Significant differences between PSC and various factors, including sex, age, education level, household income level, number of chronic diseases, depression, anxiety, suicidal thoughts, poor self-perceived health status, and regular exercise. After controlling for sex, age, household income level, and education level, the presence or absence of PSC had a significant association on stress, anxiety, suicidal thoughts, and poor self-perceived health. A subgroup analysis showed that the impact of participating in sports consumption on stress was significantly higher for females, older adults, and regular exercisers. Additionally, older adults showed a significant difference in the impact of PSC on anxiety and self-perceived health status compared to other age groups. Conclusions PSC is associated with improvement in mental health, including those with chronic conditions, and older adults experience greater benefits from PSC than younger individuals.
Second harmonic electron paramagnetic resonance spectroscopy and imaging reveal metallic lithium depositions in Li-ion batteries
Authors: Dutoit Charles-Emmanuel , Ahouari Hania , Denoyelle Quentin , Pondaven Simon , Vezin Hervé 
Published: October 2023

Abstract
We have investigated the metallic lithium particles nucleation during lithiation and delithiation of the graphite electrode using X-band electron paramagnetic resonance (EPR). Metallic lithium aggregates like dendrites and/or filaments which are formed during electrochemical cycling on the graphite anode are complex structures which may lead to internal short-circuit and safety issues. Understanding and following, in real time and real conditions, this nucleation process is necessary to improve the development of Li-ion batteries. The complexity to detect metallic lithium structures inside Li-ion batteries depends on the number of EPR lines and their linewidth. The presence of lithiated graphite phases affects the detection of micrometric Li-metal elements. Here, we report a new approach using cw-EPR spectroscopy and imaging combining the first and the second harmonic detection schemes to provide evidence of the metallic lithium aggregates nucleation in these negative electrodes. Although the first harmonic gives all of EPR signals present in the sample, it is found that the second harmonic EPR signal is mainly sensitive to metallic lithium depositions.
Integrated Rice-Multi-Trophic-Aquaponics and Rice-Tilapia- Monoculture Systems as Environmental Techniques for Optimizing Water, Feed Conversion Ratio, Nitrogen, and Phosphorus Use Efficiency
Authors: Goda Ashraf , Aboseif Ahmed M. , Mohammady Eman Y. , Taha Mostafa K.S. , Mansour Ahmed A. , Aboushabana Nevine M. , Ramadan Enas A. , Zaher Marwa M. , Otazua Nora Ibáñez , Ashour Mohamed 
Published: October 2023

Abstract
Currently, there is an increasing demand for the development of sustainable horticulture aquaculture systems that can effectively adapt to climate change conditions. In this study, we explore the potential of novel Integrated Agriculture-Aquaculture Systems (IAAS) to enhance water, nitrogen, and phosphorus-use efficiency (WUE, NUE, and PUE, respectively), while extending the nutrient cycle generated by rice and raising aquatic animals, under the conditions of climate adaptation. For 90 days, in a 2 greenhouse closed system, two types of aquatic animals-rice integrated culture systems (Tilapia (T) -Rice (R) monoculture and Integrated Multi-Trophic-Aquaculture (IMTA)-R culture system) were evaluated within two rice hydroponic culture techniques of Floating Raft System (FRS) and Nutrient Film Technique (NFT). Four treatments were conducted in this study. Treatments 1 and 2 were IMTA-R cultivation systems using FRS and NFT techniques (IMTA-R-FRS and IMTA-R-NFT, respectively). Treatments 3 and 4 were T-R cultivation systems using FRS and NFT techniques (T-R-FRS and T-R-NFT, respectively). All treatments (IMTA-R-FRS, IMTA-R-NFT, T-R-FRS, and T-R-NFT) were conducted in 2 separate greenhouses using indoor-recycling closed systems. The results found that integrated IMTA-R and T-R using the FRS technique are particularly promising for optimizing WUE, NUE, and PUE than the NFT technique. These systems offer a potential solution to the challenges of climate change, which requires a more sustainable and resilient food production system. On the other hand, IMTA-R-FRS is particularly promising for optimizing WUE, NUE, and PUE, and the variety of aquatic animal production yield (such as mullets, crayfish, freshwater mussels, and silver carp) than the T-R-FRS technique.
Simultaneous resonance in multi-frequency atomic force microscopy
Authors: Kouchaksaraei Mostafa Ghanbari , Bahrami Arash 
Published: October 2023

Abstract
We propose a new excitation technique based on simultaneous resonance phenomenon to improve performance of the multi-frequency atomic force microscopy. Simultaneous resonances, activated due to the nonlinear nature of the tip oscillations and intermodal couplings for a certain family of multi-frequency excitations, may be used to gather more information about the sample. We consider a non-contact atomic force microscope and model the three-dimensional probe-tip structure as an Euler-Bernoulli beam. Equations governing motion of the probe tip are obtained employing the Hamilton extended principle. Direct harmonic balance method is then used to solve these equations. It is found out, through extensive numerical simulations, that the present excitation scheme improves both the vertical resolution and the compositional contrast of images. Numerical investigations demonstrate that a small change in the Hamaker constant and the initial tip-sample distance leads to a significant change in the amplitude and/or phase shift of the simultaneous resonance. High sensitivity of the amplitude to the initial tip-sample distance can be utilized to reduce vertical noise, and therefore increase the vertical resolution in environments with high and low quality factors. Also, simultaneous resonance phase shift sensitivity to the Hamaker constant is noticeably increased compared to that of the conventional multi-frequency atomic force microscopy. As a result, the compositional contrast is considerably enhanced.
Cost Optimized Hybrid Distributed Load Balancing in Cloud
Authors: Sundaragiri Jyothsna , K K.Radhika 
Published: October 2023

Abstract
Cloud computing is a utility computing with a huge collection of resources at the datacenter. When a client requests a particular task be performed, the request is routed to a server that has the resources to do the task and the server is scheduled using broker policy. A suitable virtual machine (VM) operating on it in turn handles the request. The current work suggests a cost-optimized hybrid load balancing method in cloud COHDLBC that chooses the virtual machine to assign jobs depending on the VM's availability and its active connections at that precise moment. Also, it examines the prices of the various virtual machines and data transfer cost to choose the one that will fulfill the request for the lowest cost. The proposed COHDLBC algorithm is implemented in GUI based cloud simulator cloud
Perceptions of work and organizational health among a sample of U.S. solid waste workers: A pilot study
Authors: Le Aurora , Shkembi Abas , Gibbs Shawn , Neitzel Richard 
Published: October 2023

Abstract
Background: Solid waste workers encounter a number of occupational hazards that are likely to induce stress. Thus, there are likely to be psychosocial factors that also contribute to their overall perceptions of health. However, attitudes regarding solid waste workers’ psychosocial environment and perceptions of organizational health have not been assessed.
Methods: This cross-sectional pilot study operationalized the INPUTS™ Survey was to determine workers’ perceptions of organizational health and other psychosocial factors of work. Percentage and mean responses to each INPUTS™ domain are presented in accordance with their survey manual. Pearson’s chi-squared tests were run on count data; Fisher’s exact tests were run for count data with less than five samples. ANOVAs were run on the continuous items. Due to a relatively low sample size (N = 68), two-sided p-values <0.1 were considered statistically significant.
Results: Most solid waste worker participants reported high decision authority, that they perceived their management to prioritize workplace health and safety and had high job satisfaction. However, perceptions of support for health outside of the realm of occupational safety and health was lower.
Conclusions: Addressing traditional occupational health hazards continues to take precedence in this industry, with less of a focus on how the social determinants of health may impact workplace health.
Enhancing Systemic Interventions by Using a Systemic Multi-methodological Framework
Authors: Paucar-Caceres Alberto , Castellini Maria Alejandra , Abuabara Leila 
Published: October 2023

Abstract
The Paper proposes a ‘Systemic Multi-methodological Framework’ for multi-methodological management science/operational research (MS/OR) interventions. Based on Mingers’ framework for mapping MS/OR methodologies/methods/techniques, we advance a systemic framework to enhance the systemic intervention in a textile SME in Argentina. The framework draws from the key elements of Flood & Jackson’s and Mingers’ concepts for multi-methodological practice. We discuss both the practical difficulties of applying Mingers’ notional systems in a real-world and the cultural and psychological obstacles that prevent the viability of a multi-method and multi-paradigm intervention. Working with stakeholders from different levels of the Argentinean small and medium-sized enterprise (SME), we test the framework and discuss the insights useful to overcome these obstacles. By proposing an original framework (and by illustration, a real-world application), we aim to contribute to the debate about the current increasing multi-methodological practice in MS/OR.
A lightweight parallel execution engine for IoT data analytics in fog computing
Authors: YIN FEI , SHI FENG 
Published: October 2023

Abstract
With the rise of fog computing, the architecture of IOT is evolving into a cloud-fog-end architecture, where fog computing and cloud computing complement each other. The Internet of Things produces a large amount of data with great value. More and more real-time data analytics scenarios need to be carried out in the fog environment. Data processing and analytics has formed a relatively mature technology stack in the cloud, but in the fog environment with limited resources, the supporting framework of data analytics is still in its infancy. This paper reviews relevant research work in this field. Furthermore, this paper proposes a new parallel programming model and its API, and constructs a lightweight parallel execution engine (LwPEE) suitable for fog computing environment. Finally, we evaluate the performance of LwPEE and conduct relevant analysis.
Real-time facial state recognition and fatigue analysis based on deep neural networks
Authors: yan Chunman , Li Jiale 
Published: October 2023

Abstract

Aiming at the problems such as large parameter count of facial state recognition model in driver fatigue detection which is difficult to be deployed, low accuracy, slow speed, etc., a lightweight real-time facial state recognition model YOLOv5-fatigue based on YOLOv5n is proposed; Firstly, a bilateral convolution (BConv) is proposed, which can fully utilize the feature information in the channel; Then an innovative deep convolution module (DBS) is proposed, which utilizes the module to reduce the number of network parameters as well as the amount of computation; Lastly, the NAM attention mechanism is added to solve the problem of accuracy degradation due to the lightweighting of the model; In this paper, we first recognize the facial state by YOLOv5-fatigue, and then use the proportion of eyes closed per unit of time (PERCLOS) and the proportion of mouth closed per unit of time (POM) to determine fatigue. Experiments on the self-built VIGP-fatigue dataset show that the AP50 of the proposed method is improved to 92.6%, the inference time is reduced to 2.1ms,and the amount of parameters is reduced to 1.01M.By comparing with the driving video in real situation, it is found that the accuracy of fatigue detection reaches 94.7%.
Long-term expansion of cereal crops promotes regional population increase of polyphagous Helicoverpa armigera
Authors: Yang Long , Li Minlong , Liu Jie , Zeng Juan , Lu Yanhui 
Published: October 2023

Abstract
Changes in land use is an important driver of insect pest population dynamics, but the long-term effects of land use may be contingent on changes in some factors. To identify potential effects of change in cropping pattern on agricultural pest population trends, data from large temporal and spatial scales are needed but are rarely available. Here, we use long-term pest monitoring data across a regional scale and across independent gradients of land-use intensity at the landscape level, to investigate the effects of the expansion of area devoted to major cereal crops on population trends of polyphagous Helicoverpa armigera in northern China. We found that an increased proportion of the land planted to maize and wheat in the landscape had an indirectly positive effect on the abundance of the summer population of H. armigera by increasing the population abundance of the preceding spring generations. Stable carbon isotope analysis suggested that maize acted as the source habitat for H. armigera population in the growing season. At the regional level, long-term expansion of maize and wheat production, as well as the contraction of cotton area, were associated with an increased density of H. armigera in spring generations across years, although temperature and precipitation factors also had significant effects on pest population sizes. These results across both temporal and spatial scales indicated that, in addition to Bt cotton contraction, increased cereal crops cultivation was an important driver of the H. armigera population increases in recent decades in northern China.
Study of the Membrane Activity of the Synthetic Peptide ∆M3 against Extended-Spectrum β-Lactamase Escherichia coli Isolates
Authors: Fandiño-Devia Estefanía , Santa-González Gloria A. , Klaiss-Luna Maria C. , Manrique-Moreno Marcela 
Published: October 2023

Abstract
Escherichia coli is the most common microorganism causing nosocomial or community-acquired bacteremia, and extended-spectrum β-lactamase-producing Escherichia coliisolates are identified worldwide with increasing frequency. For this reason, it is necessary to evaluate potential new molecules like antimicrobial peptides. They are recognized for their biological potential which makes them promising candidates in the fight against infections. The goal of this research was to evaluate the potential of the synthetic peptide ΔM3 on several extended-spectrum β-lactamase producing E. coli isolates. The antimicrobial and cytotoxic activity of the peptide spectrophotometrically determined. Additionally, the capacity of the peptide to interact with the bacterial membrane was monitored by fluorescence microscopy and infrared spectroscopy. The results demonstrated that the peptide is active against Escherichia coli isolates at concentrations similar to Meropenem. On the other hand, no cytotoxic effect was observed in keratinocyte cells even at 10 times the minimal inhibitory concentration. Microscopy results showed a permeabilizing effect of the peptide on the bacteria. The infrared results showed that ΔM3 showed affinity for the lipids of the microorganism's membrane. Finally, the peptide showed a random structure in solution that did not change during the interaction with the membranes.
The synthetic peptide ΔM3 was demonstrated to have potential antimicrobial activity against β-lactamase-producing E. coli isolates, and low cytotoxicity against HaCaT cells. The results suggest that the ∆M3 interacts with the negatively charged lipids from the E. coli by a disturbing effect on membrane. The secondary structure showed no conformational change for ∆M3.