bluuebunny/crossref_metadata_2025_split huggingface dataset:
Umbilical Cord Mesenchymal Stem Cells Combined with Fufang Xueshuantong Capsule Attenuate Oxidative Stress and Vascular Lesions
in Diabetic Rats by Activating Nrf-2/HO-1 Signaling Pathway
Authors: Sun Yunchao , Li Yongzhang , Gao Xueliang , Gao Limin , Yang Bingqi , Zhao Jianing 
Published: November 2023

Background::
Macrovascular lesions are the main cause of death and disability in
diabetes mellitus, and excessive accumulation of cholesterol and lipids can lead to long-term
and repeated damage of vascular endothelial cells. Umbilical cord mesenchymal stem cells
(UCMSCs) can attenuate vascular endothelial damage in type 1 diabetic mice, while Fufang
Xueshuantong capsule (FXC) has a protective effect on endothelial function; however, whether
FXC in combination with UCMSCs can improve T2DM macrovascular lesions as well as its
mechanism of action are not clear. Therefore, the aim of this study was to reveal the role of
FXC + UCMSCs in T2DM vasculopathy and their potential mechanism in the treatment of
T2DM.

Methods::
The control and T2DM groups were intragastrically administered with equal amounts
of saline, the UCMSCs group was injected with UCMSCs (1×106, resuspended cells with 0.5
mL PBS) in the tail vein, the FXC group was intragastrically administered with 0.58 g/kg FXC,
and the UCMSCs + FXC group was injected with UCMSCs (1×106) in the tail vein, followed
by FXC (0.58 g/kg), for 8 weeks.

Results::
We found that FXC+UCMSCs effectively reduced lipid levels (TG, TC, and LDL-C)
and ameliorated aortic lesions in T2DM rats. Meanwhile, Nrf2 and HO-1 expression were upregulated.
We demonstrated that inhibition of Nrf-2 expression blocked the inhibitory effect of
FXC+UCMSCs-CM on apoptosis and oxidative stress injury.

Conclusion::
Our data suggest that FXC+UCMSCs may attenuate oxidative stress injury and
macroangiopathy in T2DM by activating the Nrf-2/HO-1 pathway.
Role of Clinical Features, Pathogenic and Etiological Characteristics of Community-acquired Pneumonia with Type 2 Diabetes Mellitus in Early
Diagnosis
Authors: Liu Bai-Yi , Zhang Dan , Fan Zhu , Jin Jing-Jing , Li Cai-Hong , Guo Rui-Nan , Li Xue-Juan , Huang Yan 
Published: November 2023

Objective::
To study the etiological characteristics of community-acquired pneumonia
(CAP) combined with type 2 diabetes (T2D), providing a reference for early clinical diagnosis
and treatment of the disease.

Methods::
We selected a total of 93 patients with CAP and analyzed their metagenomics nextgeneration
sequencing (mNGS) data. The case group comprised 46 patients with combined
CAP/T2D, and the control group comprised 47 patients without diabetes. We analyzed the pathogenic
findings of the two groups.

Result::
There were statistically significant differences in age between the two groups
(P = 0.001). Leukocytes (P = 0.012), blood platelets (P = 0.034), fibrinogen (P = 0.037),
D-dimer (P = 0.000), calcitonin ogen (P = 0.015), ultrasensitive C-reactive protein or C-reactive
protein (CRP) (P = 0.000), serum amyloid A (P = 0.000), and erythrocyte sedimentation rate
(P = 0.003) were higher in the case group than in the control group. Albumin was lower in the
case group than in the control group. All differences were statistically significant. The infection
rates of Klebsiella pneumoniae (P = 0.030), Pseudomonas aeruginosa (P = 0.043), and Candida
albicans (P = 0.032) were significantly different between the two groups.

Conclusion::
Compared with those without diabetes, the infection rates of Klebsiella pneumoniae,
Pseudomonas aeruginosa, and Candida albicans were higher in patients with combined CAP/T2D.
Recent Patents for Optical Alignment
Authors: Li Guo , Yu Kun Peng 
Published: November 2023

Background:
The installation of optical devices is a necessary operation before their
use. Therefore, the configuration of the optical system affects the performance of the whole optical system. However, in the process of optical system installation, there are still some technical
breakthroughs to be made in order to better carry out optical system installation in the future.

Objective:
Through the introduction and discussion of the devices, methods and patent features of
optical alignment testing in recent years, some valuable conclusions are summarized, and future
research and development are prospected.

Methods:
The patents of optical system assembly were studied, and the patents and research progress of optical alignment were summarized.

Results:
With the development of optical technology, optical alignment has become more and
more important, so optical alignment is needed to realize the design of optical systems.

Conclusion:
It is concluded that there is still a large space for the development of optical alignment, and the main development trend is towards high precision and large caliber
Professional Ethics, Challenges and Opportunities for Blockchain
Technology in Healthcare Sector: A Systematic Review
Authors: Singh Keerti , Krishna Charu , Kumar Divya 
Published: November 2023

Background::
The healthcare sector faces numerous issues, such as insurance fraud,
electronic medical record management, interoperability, insecure dissemination of information,
etc. The novel Blockchain technology holds tremendous potential to transform the healthcare
sector by addressing these rising challenges in the industry. It provides a secure platform for
storing, disseminating, and retrieving sensitive patient data and health records while preserving
the ethical principles of the healthcare sector.

Method::
In this study, we systematically reviewed the literature on blockchain technology in
healthcare using PRISMA and highlighted how blockchain technology might promote innovation
and deliver major improvements in the healthcare sector.

Result::
Our goal is to examine the present status of this discipline, focusing on limits and potential
advances. Queries were used to gather Scopus, PubMed, SpringerLink, IEEE Xplore,
and Web of Science publications that met the criteria for the selection of papers.

Conclusion::
This article, thus, analyses the potential for blockchain in the healthcare industry
and outlines blockchain-based products in healthcare. Our study enhances and complements
prior healthcare blockchain research.
Attitudes, Barriers, and Motivators Toward Daily Walking and a Mobile App to Increase Walking Among Women: Web-Based Anonymous Survey
Authors: Jones Catherine , Chandarana Shikha , Vyas Amita , Napolitano Melissa 
Published: November 2023

Background
There are disparities in the prevalence of physical activity (PA) with women engaging in less PA than men, a gap which widens during midlife. Walking is a generally accepted form of PA among women and should be encouraged. Motivations, barriers, and attitudes to engaging in walking change with age, but the influencing factors are not well understood nor are the features of mobile apps that facilitate daily walking.

Objective
This study explores the relationship between age and women’s self-reported motivations, barriers, attitudes, and beliefs toward daily walking. It further assesses attitudes toward features of a mobile app designed to sync with a wearable step tracker to increase and maintain levels of daily walking among women.

Methods
A web-based anonymous survey was completed by 400 women, aged 21-75 years. The 31-item survey captured women’s perceived barriers and motivators toward daily walking and attitudes toward mobile apps to support and maintain daily walking. For analysis, responses to the survey were grouped into 2 categories of women: ages 21-49 years and ages 50-75 years. Bivariate analyses were conducted through SPSS (IBM Corp) for each of the survey questions using chi-square for dichotomous variables and 1-tailed t tests for scales and continuous variables to identify significant differences between the groups. One-tailed t tests were run for scaled variables to identify significant differences between the 10-year age increments.

Results
Significant barriers to daily walking were observed in the 21-49–year group for personal and work responsibilities, motivational and psychosocial factors, and physical and environmental factors. Motivators to walk daily in the 21- 49–year group were significantly higher to reduce stress and anxiety, and motivators to walk daily in the 50-75–year group were significantly higher to help manage or lose weight and to reduce the risk of chronic illness. Women’s walking preferences, beliefs around their walking behaviors, and their perceived importance of the features of a future mobile app for walking designed specifically for women showed significant variation according to age. When asked about the importance of features for a mobile app, women aged 21-49 years indicated a significantly higher number of positive responses for the following features: digital community support, rewards or point system, and seeing a daily or weekly or monthly progress chart.

Conclusions
Our findings indicate that barriers, motivators, and beliefs around daily walking and the importance of preferred features of a mobile app vary according to women’s ages. Messaging and app features should be tailored to different age groups of women. These study results can be viewed as a foundation for future research and development of mobile health interventions to effectively increase daily walking among women of all ages.
Pelatihan Apresiasi Karya Sastra Jawa bagi Siswa SD Negeri Suryowijayan Yogyakarta
Authors: Prakoso Imam , Winarti Daru , Sulistyowati Sulistyowati 
Published: November 2023

It seems that geguritan still being one of the learning objects which rarely receive attention in school. This is because geguritan is stigmatized as a literature work that is difficult to understand because of its language, hence only certain people are able to appreciate it. Based on this problem, the Javanese Literature Program of UGM community service team attempted to reintroduce geguritan through literature appreciation activities to the students of Suryowijayan Elementary School. This program aims to remind them of the Javanese cultural identity which is implemented in geguritan and improve their social awareness. There were several activities including an introduction to the basic concept of geguritan, geguritan reading practice, geguritan writing practice about students’ hobbies and daily activities, and creating a wall magazine from their geguritan. At the end of the program, students read their geguritan which later turned into a compilation video as the outcome of this program.
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Kiranya apresiasi karya sastra geguritan masih menjadi bentuk pendidikan yang belum mendapatkan perhatian di lingkungan sekolah. Hal ini karena masih adanya anggapan terhadap geguritan sebagai sebuah karya sastra yang sukar dipahami karena bahasanya sehingga hanya bisa dinikmati oleh kalangan tertentu. Berangkat dari stigma tersebut, tim pengabdian kepada masyarakat dari Program Studi Bahasa, Sastra, dan Budaya Jawa UGM berupaya untuk mengenalkan kembali geguritan melalui kegiatan apresiasi karya sastra yang dilakukan terhadap siswa SD Negeri Suryowijayan. Kegiatan ini bertujuan mengingatkan kembali identitas budaya Jawa yang terwujud dalam geguritan serta meningkatkan kepedulian sosial akan berbagai peristiwa dalam kehidupan sehari-hari. Bentuk pembelajaran yang dilakukan dalam kegiatan ini terdiri atas beberapa tahap, yaitu pengenalan konsep dasar geguritan, latihan membaca geguritan, latihan menulis geguritan tentang hobi serta keseharian siswa, dan pembuatan karya mading dari geguritan. Pada akhirnya, karya mading tersebut dibaca oleh siswa dan divisualisasikan menjadi sebuah video kompilasi sebagai bentuk luaran program pengabdian.
Motif disabilitas netra berprofesi sebagai pustakawan
Authors: Valentino Rahmat Alifin , Rusmana Agus , Damayani Ninis Agustini 
Published: November 2023

Introduction. The number of librarian with disability, particularly with limited ability to see or blind is not many. This research explores the motives of the blind on why becoming librarians.
Research methods. This study used a qualitative research method with a phenomenological approach. Data collection techniques used observations and interviews. Sampling was decided purposively.
Analysis data. Research analysis was conducted through the stages of data reduction, data display, and conclusion drawing. Data validation techniques were carried out using credibility tests.
Results and Discussion. The motive to become a librarian refers to Alfred Schutz's phenomenological theory which can be divided into two categories: motives based on because-motive (Weil-Motiv), namely the hobby of reading, lack of reading material for blind people, and library facilities that support performance for librarians with visual disabilities. Motives based on the in-order-to motive (Um-zu-Motiv) are to change the social stigma of people with visual disabilities, increase readers’ interest in reading, socialize braille collections, increase economic levels, and increase relationships.
Conclusion. The findings show that being a librarian with visual disabilities is oriented towards past and future motives.
Community engagement through Library and Information Science teaching- learning activities at Islamic higher education in Indonesia
Authors: Labibah Labibah , Marwiyah Marwiyah , Mudawamah Nita Siti , Puspita Anindya Gita , Anjarwati Siwi 
Published: November 2023

Introduction. Community engagement is one of the ways to connect between academic environment and community. This research aims to explore community engagement as part of the course in the Library Science Study Program to match with the seven main principles of community engagement.
Research Method. This is qualitative research with a case study approach on how community engagement concept is implemented in the learning and teaching activities at UIN Sunan Kalijaga Yogyakarta and UIN Maulana Malik Ibrahim Malang.
Data analysis. The data was analyzed by using cross-case data analysis.
Results and Discussion. The results show that the two LIS Programs have conducted community engagement effectively in their learning and teaching by referring to the main seven principles of community engagement.
Conclusion. In terms of the community engagement, UIN Malang has more intensive relationships with the community because their activities involve wider community around the area. While in terms of the sustainability, UIN Yogyakarta shows a better-organized program as they assign the students to create strategic plans and SOPs by encouraging the community library organizers to continue what has been conducted by the students during the program. This community engagement program also in line with community service missions of the university.
Novel Researched Herbal Sunscreen Cream SPF Determination by In-Vitro Model
Authors: Pandey Prateek , Sharma Anil , Sharma Hariom , Vyas Girish Kumar , Sharma Manmohan 
Published: November 2023

INTRODUCTION: Researchers' interest in creating novel cosmetic formulations has increased due to consumer interest in herbal cosmetics and increased patent activity. The rights of indigenous traditional knowledge and benefit sharing are also safeguarded under IPR.
OBJECTIVE: To formulate and evaluate herbal sunscreen with determination of Sun Protection Factor (SPF) and anti-oxidant activity. To compare Sun Protection Factor of developed formulation with marketed formulation.
METHOD: The formulation was developed according to the prepared formula. And multiple tests were done for evaluation i.e., physical observation, spreadability, extrudability, occlusion study, stability study and SPF determination. All the evaluations were found satisfactory. Characterisation of SPF was calculated according to the and UV-Vis Spectrophotometer (LABMAN Scientific instruments Pvt. Ltd.).
RESULTS:The synergistic activity of all herbal compounds utilized in herbal sunscreen formulations, such as Cucumis sativus, Solanum Lycopersicon, and Aloe barbadensis Efficacy of photoprotection found in following order Marketed formulation > F3 > F2 > F1. For prepared formulation F3 provided better results in comparison to Formulation1 and Formulation 2. Formulation 3 was compared with marketed preparation and it showed good SPF value nearer to market preparation. Overall results were satisfactory. These results reveal that the prepared F3 herbal sunscreen have good SPF and good sun protection activity.
CONCLUSION: Formulation 3, which consists of three formulations, has been found to be effective as sunscreen in every way. Since few people use sunscreen, there is a need to raise public knowledge of the risks associated with sun exposure as well as the advantages of using sun protection products on a regular basis to lessen these effects. This kind of research will be useful in offering consumers with an all-inclusive solution or product that will protect them from the damaging effects of sunlight.
A Review on Pharmaceutical Emulsion
Authors: Thakur Rakesh , Sharma Anjali , Verma Preeti , Devi Asha 
Published: November 2023

The pharmaceutical term “emulsion” is most time used to indicate preparations prepared for internal use. This pharmaceutical dosage form is thermodynamically unstable and must be stabilized by the addition of emulsifying agent. Emulsified systems range from lotions having comparatively low viscosity to creams which are more viscous. There are two basic types of emulsions, that is, oil in water (O/W) and water in oil (W/O). In addition to these two types, a relatively complex emulsion, called multiple emulsions can also be formulated. Emulsions generally have certain advantages over other dosage forms as the drug solubilized may be more bioavailable. Moreover, gastrointestinal problems and first pass metabolic effect are also avoided.
A Review on Artificial Intellegence in Drug Discovery & Pharmaceutical Industry
Authors: Laddha C.S. , Shelke A.V. , Vaidya Y.V. , Sheikh A.A. , Biyani K.R. 
Published: November 2023

Introduction: The use of artificial intelligence (AI) in drug discovery and the pharma industry has been rapidly expanding in recent years. AI algorithms can analyze vast amounts of data, identify patterns, and make predictions that can accelerate drug discovery and improve patient outcomes.
Methods: AI is being used in various stages of the drug discovery process, from target identification and lead optimization to clinical trials and post-market surveillance. Machine learning algorithms, neural networks, and natural language processing are among the AI techniques used in drug discovery.
Results: AI-based drug discovery has already shown promising results, with several drugs in clinical trials or approved for use that were discovered using AI. AI is also being used to improve clinical trial design and patient selection, as well as to monitor adverse drug events and optimize drug dosing.
Conclusion: AI has the potential to transform the drug discovery and pharma industry, making drug development faster, more efficient, and more effective. However, there are still challenges that need to be addressed, such as the need for high-quality data and the potential for bias in AI algorithms. Overall, the use of AI in drug discovery and the pharma industry is an exciting and rapidly evolving field that has the potential to improve patient outcomes and revolutionize healthcare.
In silico and in vitro testing Ascorbic Acid Protects Nicotine-Treated Human Erythrocytes
Authors: Panda Pratikeswar , Sahu Arpita , Mohapatra Sagarika 
Published: November 2023

Objectives: Nicotine is a naturally occurring drug that is highly addictive and is commonly found in tobacco products. Tobacco products are one of the leading causes of lung and oral cancer worldwide. Because blood is the primary organ in contact with nicotine, our goal in this study was to confirm its effect on blood. We also investigated the protective role of ascorbic acid on nicotine toxicity.
Methods: Various blood toxicity studies were carried out using in-vitro and in-silico methods. Nicotine-induced haematological perturbation resulted in haemolysis, decreased superoxide dismutase and catalase activities, and decreased total antioxidant capacity in erythrocytes.
Results and Conclusions: The results showed that nicotine has a negative effect on red blood cells in the lysis assay and causes clots to form in nicotine-treated samples in the blood clotting analysis. Furthermore, the in-Silico method validated the in-vitro results. According to our findings, ascorbic acid has blood-protective properties. Ascorbic acid was discovered to increase SOD, catalase, and total antioxidant activity. Ascorbic acid also reduced the damage caused by nicotine to RBCs in the lysis assay and demonstrated a high level of protection against the formation of clots when the samples were treated with nicotine. The findings suggest that ascorbic acid, an antioxidant, can protect against nicotine-induced haematological damage.
Novel Drug Delivery System: Brief Review
Authors: Dhiman Jasmine 
Published: November 2023

Current developments in our knowledge of the pharmacokinetic and pharmacodynamics behaviour of drugs provide a more logical framework for designing the best possible drug delivery system. It is understandable that multidisciplinary efforts will play a major role in the success of drug delivery research in the future. Any therapeutic agent that has the potential to be safer, more effective, and use an enhanced drug delivery mechanism offers pharmaceutical companies significant marketing prospects as well as advancements in the treatment of illnesses. Since ancient times, humans have utilized plants as food and medicine, viewing them as nature's solutions. The underlying idea is that every sickness has a remedy that is concealed in better ways using ayurvedic, homeopathic and allopathic. However, in order to promote sustained release, improve patient compliance, etc., the way herbal medications are delivered must also be modified. Because of challenges with processing, standardizing, extracting, and identifying them, herbal medications had historically been unable to draw scientists' attention to the development of novel drug delivery methods. However, with today's technological advancements, the development of herbal revolutionary drug delivery systems is made possible by novel drug delivery systems (NDDS). It is possible to achieve protection against toxicity, stability enhancement, enhanced bioavailability, and protection against chemical and physical degradation of herbal formulations through the application of advanced procedures which must give the result in better or faster way. In this review we will get the method of preparations of NDDS and the Application of NDDS.
Keywords: Herbal Drugs, Enhanced drug delivery, Phytosomes, Nanoparticles, liposomes.
Representações sociais de discentes do curso de Engenharia de Alimentos sobre a relação professor-estudantes
Authors: Ribeiro Marinalva Lopes , Silva Alexsandra de Santana Soares 
Published: November 2023

O artigo apresenta resultados de uma pesquisa descritiva de abordagem qualitativa, cujo objetivo geral foi compreender os sentidos atribuídos por estudantes para a relação professor-estudantes, e o objetivo específico visava destacar a organização do conteúdo das representações de relação professor-estudantes. Na produção de dados, aplicamos um questionário a 53 estudantes do Curso de Engenharia de Alimentos com a Técnica Associação Livre de Palavras. Na análise dos dados usamos operações estatísticas simples, as quais ajudaram a organizar a estrutura das representações dos sujeitos. Os resultados apontam que para alguns estudantes, a relação professor-estudantes tem sentido de amizade, respeito, compreensão, empatia, ao passo que para outros têm sentido de distanciamento, hierarquia, dificuldade, o que nos faz concluir que tais representações discrepantes são produtos histórico-sociais relacionados às práticas dos indivíduos, que podem influenciar diretamente o processo de aprendizagem dos graduandos.