bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Affective Temperament, Pain Catastrophizing, and Anxiety Sensitivity on Pain Severity in Patients With Chronic Pelvic Pain: A Pilot Study
Authors: Kayacik Günday Özlem , Harmanci Hatice , Şenol Yiğit 
Published: October 2023

Objective:
The goals of this study were to investigate whether there was a dominant temperament type, and to assess the effect of temperament, pain catastrophizing, and anxiety sensitivity on pain severity, in female patients diagnosed with chronic pelvic pain (CPP) compared with healthy controls.

Methods:
This cross-sectional study involved 51 patients 18 to 65 years of age who were diagnosed with CPP without a history of psychiatric treatment and 97 healthy volunteer women with sociodemographic characteristics similar to those of the study group. A sociodemographic form prepared by the researchers, the Anxiety Sensitivity Index, the Pain Catastrophizing Scale, a temperament scale (Temperament Evaluation of Memphis, Pisa, Paris, and San Diego–Autoquestionnaire), and a visual analog pain scale (VAS) were completed. The results were compared between the patient and control groups. Multiple regression analyses were performed to examine the predictive effects of temperament characteristics, pain catastrophizing, and anxiety sensitivity on pain severity.

Results:
Scores on the Pain Catastrophizing Scale and the VAS were statistically significantly higher in the CPP group (P<0.001). The frequency of depressive, cyclothymic, and irritable temperaments was found to be significantly higher in the CPP group (CPP: 7.78±3.32 vs. controls: 6.54±3.19; P=0.027; CPP:10.61±4.41 vs. controls: 8.82±4.21; P=0.017; CPP: 5.22±4.29 vs. controls: 3.75±3.41; P=0.025). According to the model established by temperament traits, anxiety sensitivity, and pain catastrophizing level, pain catastrophizing level explained 11.6% of the variance in pain severity. A 1-unit change in the score for pain catastrophizing level caused a 0.278-point change in the VAS total score (P<0.01).

Conclusions:
Cyclothymic, depressive, and irritable temperament types that increase the risk of affective disease are more common in patients with CPP. The level of pain catastrophizing in patients with CPP affects their perception of the severity of the pain.
Borrmann Type IV Gastric Cancer: Computed Tomography Features and Corresponding Pathological Findings
Authors: Ji Changfeng , Ma Yi , Zheng Zhong , Liu Song , Zhou Zhengyang 
Published: October 2023

Objective
We aimed to analyze the association between computed tomography (CT) features and the corresponding pathological findings in Borrmann type IV (BT-4) gastric cancers and explore the pathological basis of the characteristic CT features.

Methods
This retrospective study included 84 patients with BT-4 gastric cancers who underwent contrast-enhanced CT and surgical resection. Preoperative CT features were evaluated, including the major location, range, circumferential invasion, perigastric fat infiltration, enlarged lymph nodes, layered enhancement, degree of enhancement, and peak enhanced phase. Postoperative pathological findings were also recorded. Differences in CT features according to different World Health Organization types, surgical margin, adjacent organ invasion, and peritoneal status were assessed using the χ2 or Fisher exact test (n < 5).

Results
The most common World Health Organization type of BT-4 gastric cancer was poorly cohesive carcinoma (65.5%), which tended to show circumferential invasion, fewer enlarged lymph nodes, and layered enhancement. Although 82 patients with BT-4 gastric cancer (97.6%) had positive lymph nodes, only 26 (31.0%) had enlarged lymph nodes. Lesions originating from the gastroesophageal junction had a higher rate of positive margins (P < 0.05). Adjacent organ invasion was more likely to occur in lesions with perigastric fat infiltration (P < 0.05). Patients with circumferential invasion tended to show peritoneal metastasis (P < 0.05).

Conclusions
The characteristic CT features of BT-4 gastric cancer may be attributed to the corresponding pathological findings. Recognizing the association between CT features and pathological findings may help evaluate the aggressiveness of BT-4 gastric cancers.
Association of Systemic Lupus Erythematosus Disease Activity With Choroidal Thickness
Authors: Lee Iris , Gomez Andrea Ramirez , Kim Alfred H.J. , Coble Dean W. , Marshall Brigid , Shah Aaditya , Eisen Seth , Apte Rajendra S. , Li Tingting 
Published: October 2023

Objective
To determine the association between disease activity and choroidal thickness in patients with systemic lupus erythematosus (SLE).

Methods
We conducted a cohort study of 24 SLE patients and 13 healthy controls recruited at Washington University School of Medicine between June 2019 and November 2021. SLE disease activity was assessed using the SLE Disease Activity Index-2000 Responder Index-50 (S2K RI-50). Patients were divided into four groups: high disease activity/no lupus nephritis (HDA/no LN; S2K RI-50 > 4), HDA/active LN (HDA/active LN; S2K RI-50 > 4), low disease activity/inactive LN (LDA/inactive LN; S2K RI-50 ≤ 4), and LDA/no LN (LDA/no LN; S2K RI-50 ≤ 4). LDA/no LN patients were age-, sex-, and race-matched to healthy controls and patients in other SLE groups. Choroidal thickness of the right eye was measured blinded to disease activity on a horizontal section through the fovea on optical coherence tomography images taken within a week of disease assessment.

Results
Patients with HDA had choroidal thickening compared with matched patients with LDA. After controlling for multiplicity, choroidal thinning remained statistically significant at 1000 μm nasal to the fovea (308 ± 68 vs 228 ± 64 μm, p = 0.001). Choroidal thickness was not different between LDA/no LN and LDA/inactive LN or healthy controls.

Conclusion
HDA in patient with SLE is associated with increased choroidal thickness whereas comorbid inactive LN did not affect choroidal thickness. Additional studies in a larger longitudinal cohort are needed to study whether choroidal thickness may be used as a noninvasive, adjunctive measure for disease activity in SLE.
Quantification of Torque Teno Virus Load to Monitor Short-term Changes in Immunosuppressive Therapy in Kidney Transplant Recipients
Authors: Benning Louise , Reineke Marvin , Bundschuh Christian , Klein Julian A. F. , Kühn Tessa , Zeier Martin , Bartenschlager Ralf , Schnitzler Paul , Morath Christian , Speer Claudius 
Published: October 2023

Background.
Quantification of torque teno virus (TTV) has been proposed as a surrogate parameter to monitor immunocompetence in kidney transplant recipients (KTRs) early after transplantation. However, its use in monitoring short-term changes of immunosuppression in KTRs late after transplantation requires further investigation.

Methods.
In this post hoc analysis, we quantified TTV load in sera of 76 KTRs, with 43 pausing mycophenolic acid (MPA) 1 wk before to 4 wk after COVID-19 vaccination to increase vaccine response. TTV load was quantified before, 4 wk, and 3 mo postvaccination. Results were compared to 33 KTRs with continued standard immunosuppressive therapy and with 18 hemodialysis as well as 18 healthy control subjects.

Results.
TTV load before vaccination was with a median (interquartile range) of 1.39 × 104 copies/milliliter (c/mL) (9.17 × 101–2.66 × 105 c/mL) highest in KTRs compared to 1.73 × 103 c/mL (1.07 × 103–1.31 × 104 c/mL) in hemodialysis patients and 1.53 × 102 c/mL (6.38–1.29 × 103 c/mL) in healthy controls. In KTRs with MPA withdrawal, TTV load decreased significantly from a median (interquartile range) of 1.11 × 104 c/mL (4.75 × 102–1.92 × 105 c/mL) to 5.24 × 103 c/mL (6.92 × 102–6.91 × 104 c/mL) 4–5 wk after initiation of MPA withdrawal (P = 0.003). In patients with MPA withdrawal, TTV load was significantly inversely correlated with COVID-19 or SARS-CoV-2–specific antibodies 4 wk and 3 mo postvaccination (P = 0.009 and P = 0.004).

Conclusions.
TTV load reflects changes in immunosuppressive therapy even late after transplantation, supporting its use to monitor immunocompetence in KTRs.
The Impact of Physician-Patient Gender Match on Healthcare Quality: An Experiment in China
Authors: Si Yafei , Chen Gang , Su Min , Zhou Zhongliang , Yip Winnie , Chen Xi 
Published: October 2023

AbstractDespite growing evidence of gender disparities in healthcare utilization and health outcomes, there is a lack of understanding of what may drive such differences. Designing and implementing an experiment using the standardized patients’ approach, we present novel evidence on the impact of physician-patient gender match on healthcare quality in a primary care setting in China. We find that, compared with female physicians treating female patients, the combination of female physicians treating male patients resulted in a 23.0 percentage-point increase in correct diagnosis and a 19.4 percentage-point increase in correct drug prescriptions. Despite these substantial gains in healthcare quality, there was no significant increase in medical costs and time investment. Our analyses suggest that the gains in healthcare quality were mainly attributed to better physician-patient communications, but not the presence of more clinical information. This paper has policy implications in that improving patient centeredness and incentivizing physicians’ efforts in consultation (as opposed to treatment) can lead to significant gains in the quality of healthcare with modest costs, while reducing gender differences in care.
Chrysin directing an enhanced solubility through the formation of a supramolecular cyclodextrin-calixarene drug delivery system: a potential strategy in antifibrotic diabetes therapeutics
Authors: Hermenean Anca , Dossi Eleftheria , Hamilton Alex , Trotta Maria Consiglia , Russo Marina , Lepre Caterina Claudia , Sajtos Csilla , Rusznyák Ágnes , Váradi Judit , Bácskay Ildikó , Budai István , D’Amico Michele , Fenyvesi Ferenc 
Published: October 2023

AbstractCalixarene 0118 (OTX008) and chrysin (CHR) are promising molecules for the treatment of fibrosis and diabetes complications but require an effective delivery system to overcome their low solubility and bioavailability. Sulfobutylated β-cyclodextrin (SBECD) was evaluated for its ability to increase the solubility of CHR by forming a ternary complex with OTX008. The resulting increase in solubility and the mechanisms of complex formation were identified through phase-solubility studies, while dynamic light-scattering assessed the molecular associations within the CHR-OTX008-SBECD system. Nuclear magnetic resonance, differential scanning calorimetry, and computational studies elucidated the interactions at the molecular level, and cellular assays confirmed the system’s biocompatibility. Combining SBECD with OTX008 enhances CHR solubility more than using SBECD alone, by forming water-soluble molecular associates in a ternary complex. This aids in the solubilization and delivery of CHR and OTX008. Structural investigations revealed non-covalent interactions essential to complex formation, which showed no cytotoxicity in hyperglycemicin vitroconditions. A new ternary complex has been formulated to deliver promising antifibrotic agents for diabetic complications, featuring OTX008 as a key structural and pharmacological component.
The Trajectory of Depression and Anxiety Among Children and Adolescents over Two Years of the COVID-19 Pandemic
Authors: Korczak Daphne J. , Lo Ronda F. , Rizeq Jala , Crosbie Jennifer , Charach Alice , Anagnostou Evdokia , Birken Catherine S. , Monga Suneeta , Kelley Elizabeth , Nicolson Rob , Arnold Paul D. , Maguire Jonathon L. , Schachar Russell J. , Georgiades Stelios , Burton Christie L. , Cost Katherine Tombeau 
Published: October 2023

AbstractLongitudinal research examining children’s mental health (MH) over the course of the COVID-19 pandemic is scarce. We examined trajectories of depression and anxiety over two pandemic years among children with and without MH disorders. Parents and children 2-18 years completed surveys at seven timepoints (April 2020 to June 2022). Parents completed validated measures of depression and anxiety for children 8-18 years, and validated measures of emotional/behavioural symptoms for children 2-7 years old; children ≥10 years completed validated measures of depression and anxiety. Latent growth curve analysis determined depression and anxiety trajectories, accounting for demographics, child and parent MH. Data were available on 1315 unique children (1259 parent-reports; 550 child-reports). Trajectories were stable across the study period, however individual variation in trajectories was statistically significant. Of included covariates, only initial symptom level predicted symptom trajectories. Among participants with pre-COVID data, a significant increase in depression symptoms relative to pre-pandemic levels was observed. Children and adolescents experienced elevated and sustained levels of depression and anxiety during the two-year period. Findings have direct policy implications in the prioritization and of maintenance of educational, recreational, and social activities with added MH supports in the face of future events.
Daily variation in blood glucose levels during continuous enteral nutrition in patients on the Intensive Care Unit: a retrospective observational study
Authors: Hiemstra Floor W. , Stenvers Dirk Jan , Kalsbeek Andries , de Jonge Evert , van Westerloo David J. , Kervezee Laura 
Published: October 2023

AbstractBackgroundThe circadian timing system coordinates daily cycles in physiological functions, including glucose metabolism and insulin sensitivity. Here, the aim was to characterize the 24-hour variation in glucose levels in critically ill patients during continuous enteral nutrition after controlling for potential sources of bias.MethodsTime-stamped clinical data from adult patients who stayed in the Intensive Care Unit (ICU) for at least 4 days and received enteral nutrition were extracted from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Linear mixed-effects and XGBoost modelling were used to determine the effect of time of day on blood glucose values.FindingsIn total, 207,647 glucose measurements collected during enteral nutrition were available from 6,929 ICU patients. Using linear mixed-effects modelling, time of day had a significant effect on blood glucose levels (p<0·001), with a peak of 9·6 [9·5 – 9·6; estimated marginal means, 95% CI] mmol/L at 10:00 in the morning and a trough of 8·6 [8·5 – 8·6] mmol/L at 03:00 at night. A similar impact of time of day on glucose levels was found with the XGBoost regression model.InterpretationThese results revealed marked 24-hour variation in glucose levels in ICU patients even during continuous enteral nutrition. This 24-hour pattern persists after adjustment for potential sources of bias, suggesting it may be the result of endogenous biological rhythmicity.FundingThis work was supported by a VENI grant (2020-09150161910128) from the Netherlands Organization for Health Research and Development (ZonMw), an institutional project grant, and by the Dutch Research Council (NWO).
Tumor Purity-Related Genes for Predicting the Prognosis and Drug Sensitivity of DLBCL Patients
Authors: Ye Zhenbang , Huang Ning , Fu Yongliang , Tian Rongle , Huang Wenting 
Published: October 2023

AbstractBackgroundDiffuse large B-cell lymphoma (DLBCL) is the predominant type of malignant B-cell lymphoma. Although various treatments have been developed, the limited efficacy calls for more and further exploration of its characteristics.MethodsDatasets from Gene Expression Omnibus (GEO) database were used for identifying the tumor purity of DLBCL. Survival analysis was employed for analyzing the prognosis of DLBCL patients. Immunohistochemistry was conducted to detect the important factor that influenced the prognosis. Drug sensitive prediction was performed to evaluate the value of the constructed model.ResultsVCAN, CD3G and C1QB were identified as three key genes that impacted the outcome of DLBCL patients both in GEO datasets and samples from our center. Among them, VCAN and CD3G+ T cells were correlated with favorable prognosis, and C1QB was correlated with worse prognosis. The ratio of CD68+ macrophages and CD8+ T cells was associated with better prognosis. In addition, CD3G+ T cells ratio was significantly correlated with CD68+ macrophages, CD4+ T cells and CD8+ T cells ratio, indicating it could play an important role in the anti-tumor immunity in DLBCL. The riskScore model constructed based on the RNASeq data of VCAN, C1QB and CD3G work well in predicting the prognosis and drug sensitivity.ConclusionVCAN, CD3G and C1QB were three key genes that influenced the tumor purity of DLBCL, and could also exert certain impact on drug sensitivity and prognosis of DLBCL patients.
Modelling the health and economic impacts of M72/AS01Evaccination and BCG-revaccination: estimates for South Africa
Authors: Sumner Tom , Clark Rebecca A. , Mukandavire Christinah , Portnoy Allison , Weerasuriya Chathika K. , Bakker Roel , Scarponi Danny , Hatherill Mark , Menzies Nicolas A. , White Richard G. 
Published: October 2023

AbstractBackgroundTuberculosis remains a major public health problem in South Africa, with an estimated 300,000 cases and 55,000 deaths in 2021. New tuberculosis vaccines could play an important role in reducing this burden. Phase IIb trials have suggested efficacy of the M72/AS01Evaccine candidate and BCG-revaccination. The potential population impact of these vaccines is unknown.MethodsWe used an age-stratified transmission model of tuberculosis, calibrated to epidemiological data from South Africa, to estimate the potential health and economic impact of M72/AS01Evaccination and BCG-revaccination. We simulated vaccination scenarios over the period 2025–2050 with a range of product characteristics and delivery strategies. We calculated reductions in tuberculosis cases and deaths and costs and cost-effectiveness from health-system and societal perspectives.ResultsM72/AS01Evaccination may have a larger impact than BCG-revaccination, averting approximately 80% more cases and deaths by 2050. Both vaccines were found to be cost-effective (compared to no new vaccine) across a range of vaccine characteristics and delivery strategies. The impact of M72/AS01Eis dependent on the assumed efficacy of the vaccine in uninfected individuals. Extending BCG-revaccination to HIV-infected individuals on ART had minimal effect on the health impact, but increased costs by approximately 70%.ConclusionsOur results show that M72/AS01Evaccination or BCG-revaccination could be cost-effective in South Africa. However, there is considerable uncertainty in the estimated impact and costs due to uncertainty in vaccine characteristics and the choice of delivery strategy.
The Effects of Decreased Frame Rate During Cardiac Catheterization on Patient and Radiation Safety Outcomes
Authors: Oredegbe Al-Ameen , Derakhshesh Matthew , Vuthoori Ravi , Torosoff Mikhail , Nappi Anthony , Yager Neil 
Published: October 2023

AbstractObjectiveCoronary artery disease (CAD) is an important cause of morbidity and mortality all over the world. Cardiac catheterization is one of the most important treatment modalities in managing CAD. Unfortunately, cardiac catheterization is associated with significant ionizing radiation exposure to both patients and personnel. This study aimed to compare the safety and efficacy of a lower video frame rate of 7.5-fps compared with the standard frame rate of 15-fps.Materials and MethodsWe retrospectively collected and reviewed data from 84 cardiac catheterizations performed between January and February 2020 at a single tertiary center. The patients were divided into two groups based on frame rate: 15-fps (n=42) and 7.5-fps (n=42). We compared the two groups in terms of demographic data, procedural characteristics, radiation dose, and patient outcomes.ResultsCumulative air kerma was significantly lower in the 7.5-fps group (266.576 mGy) compared to the 15-fps group (524.140 mGy), p=0.0018. Similarly, total dose area product was lower in the 7.5-fps group (15335.617 mGy × cm2compared to the 15-fps group (34784.095 mG × cm2), p = 0.0003. Despite this, total fluoroscopic time did not differ between the two groups 7.74 minutes in the 15-fps group and 8.462 minutes in the 7.5-fps group, p = 0.4023). In addition, 30-day mortality 0% in both groups and there were no differences in the number of repeat PCIs performed within 30 days (6 in 7.5-fps and 3 in the 15-fps group), p = 0.2899.ConclusionDuring cardiac catheterization, a fluoroscopy rate of 7.5-fps is associated with lower radiation dose compared to 15-fps without an associated increase in fluoroscopy time, mortality or repeat PCI. Therefore, interventionalists should consider using a fluoroscopy rate of 7.5-fps during cardiac catheterization.
High-riskEscherichia coliclones that cause neonatal meningitis and association with recrudescent infection
Authors: Nhu Nguyen Thi Khanh , Phan Minh-Duy , Hancock Steven J. , Peters Kate M. , Alvarez-Fraga Laura , Forde Brian M. , Andersen Stacey B. , Miliya Thyl , Harris Patrick N.A. , Beatson Scott A. , Schlebusch Sanmarie , Bergh Haakon , Turner Paul , Brauner Annelie , Westerlund-Wikström Benita , Irwin Adam D. , Schembri Mark A. 
Published: October 2023

AbstractNeonatal meningitis is a devastating disease associated with high mortality and neurological sequelae.Escherichia coliis the second most common cause of neonatal meningitis in full-term infants (herein NMEC) and the most common cause of meningitis in preterm neonates. Here we investigated the genomic relatedness of a collection of 58 NMEC isolates spanning 1974-2020 and isolated from seven different geographic regions. We show NMEC are comprised of diverse sequence types (STs), with ST95 (34.5%) and ST1193 (15.5%) the most common. No single virulence factor was conserved in all isolates; however, genes encoding fimbrial adhesins, iron acquisition systems, the K1 capsule, and O antigen types O18, O75 and O2 were most prevalent. Antibiotic resistance genes occurred infrequently in our collection. We also monitored the infection dynamics in three patients that suffered recrudescent invasive infection caused by the original infecting isolate despite appropriate antibiotic treatment based on antibiogram profile and resistance genotype. These patients exhibited severe gut dysbiosis. In one patient, the causative NMEC isolate was also detected in the fecal flora at the time of the second infection episode and after treatment. Thus, although antibiotics are the standard of care for NMEC treatment, our data suggests that failure to eliminate the causative NMEC that resides intestinally can lead to the existence of a refractory reservoir that may seed recrudescent infection.