bluuebunny/crossref_metadata_2025_split huggingface dataset:
The first use of a photogrammetry drone to estimate population abundance and predict age structure of threatened Sumatran elephants
Authors: Rahman Dede Aulia , Herliansyah Riki , Subhan Beginer , Hutasoit Donal , Imron Muhammad Ali , Kurniawan Didik Bangkit , Sriyanto Teguh , Wijayanto Raden Danang , Fikriansyah Muhammad Hilal , Siregar Ahmad Faisal , Santoso Nyoto 
Published: December 2023

AbstractWildlife monitoring in tropical rainforests poses additional challenges due to species often being elusive, cryptic, faintly colored, and preferring concealable, or difficult to access habitats. Unmanned aerial vehicles (UAVs) prove promising for wildlife surveys in different ecosystems in tropical forests and can be crucial in conserving inaccessible biodiverse areas and their associated species. Traditional surveys that involve infiltrating animal habitats could adversely affect the habits and behavior of elusive and cryptic species in response to human presence. Moreover, collecting data through traditional surveys to simultaneously estimate the abundance and demographic rates of communities of species is often prohibitively time-intensive and expensive. This study assesses the scope of drones to non-invasively access the Bukit Tigapuluh Landscape (BTL) in Riau-Jambi, Indonesia, and detect individual elephants of interest. A rotary-wing quadcopter with a vision-based sensor was tested to estimate the elephant population size and age structure. We developed hierarchical modeling and deep learning CNN to estimate elephant abundance and age structure. Drones successfully observed 96 distinct individuals at 8 locations out of 11 sampling areas. We obtained an estimate of the elephant population of 151 individuals (95% CI [124, 179]) within the study area and predicted more adult animals than subadults and juvenile individuals in the population. Our calculations may serve as a vital spark for innovation for future UAV survey designs in large areas with complex topographies while reducing operational effort.
Effects of environmental factors and intraspecific niche overlap on the body and ecological characteristics of red-tongued pit vipers (Gloydius ussuriensis)
Authors: Do Min Seock , Son Seok-Jun , Jung Ji-Hwa , Lee Sang-Cheol , Choi Green , Nam Hyung-Kyu 
Published: December 2023

AbstractThe body condition of a snake species provides important physiological, morphological, and ecological information that elucidates its habits, life cycle, and competitive relationships. We measured the body size and condition of the wild Gloydius ussuriensis population in South Korea from 2018 to 2022, analyzed the degree of intraspecific niche overlap, and identified the geographic and climatic factors affecting their body condition. We found that the females were longer than the males. The body condition index (BCI) of G. ussuriensis differed depending on sex and season; the BCI of the females and males was highest in August and October, respectively. Environmental factors related to altitude and temperature affected the body condition of G. ussuriensis; BCI increased as the mean annual temperature and winter temperature increased; however, it increased when the annual temperature range decreased. The mean Pinaka index was 0.96, indicating a high degree of niche overlap; however, the niche overlap among the neonates was less than that among the adults and juveniles. To elucidate the causes of niche overlap and mechanisms behind the intraspecific competition among G. ussuriensis individuals, the habitat and utilization of food resources at different development stages of G. ussuriensis should be further investigated.
Effects of canagliflozin on cardiac remodeling and hemodynamic parameters in patients with type 2 diabetes mellitus
Authors: Kuo Hsiao-Huai , Lai Yau-Huei , Lin Po-Lin , Chen Hsin-Hao , Hung Chung-Lieh , Liu Lawrence Yu-Min , Yeh Chih-Kuang 
Published: December 2023

AbstractSodium-glucose cotransporter type 2 (SGLT2) inhibitors have demonstrated to reduce cardiovascular risk in patients with type 2 diabetes mellitus (T2DM) in large trials independent of glycemic control. The mechanisms of this cardioprotective property remain uncertain. Evidence suggests positive hemodynamic changes and favorable cardiac remodeling contributing to the clinical outcomes but results were conflicting. We aim to investigate the potential impact on hemodynamic parameters, cardiac structure and functions. This prospective observational study included T2DM patients receiving canagliflozin 100 mg per day in addition to their antidiabetic treatment. We analyzed hemodynamic parameters assessed by echocardiographic measurements and impedance cardiography (ICG) to evaluate systolic and diastolic functions from baseline to 24 weeks after treatment. A total of 47 patients (25 males and 22 females) averaging 64.6 ± 10.9 years had a significant reduction in HbA1c, body weight, and systolic blood pressure. Hematocrit increased significantly, while NT-proBNP remained unchanged. E/e′, left atrium (LA) volume, and LA stiffness were reduced, while left ventricle (LV) global longitudinal strain (GLS) and LA strain rates increased at 24 weeks by conventional and speckle tracking echocardiography. LV mass and ejection fraction showed no differences. ICG suggested significant improvement in hemodynamic parameters with increased stroke volume index and cardiac output index and decreased systemic vascular resistance index at 12 and 24 weeks. Canagliflozin improved hemodynamic parameters and had a favorable impact on LA and LV reverse remodeling. These changes may explain the beneficial effect on cardiovascular outcomes in large clinical trials.
Magnetic perovskite nanohybrid based on g-C3N4 nanosheets for photodegradation of toxic environmental pollutants under short-time visible irradiation
Authors: Sharafinia Soheila , Farrokhnia Abdolhadi , Lemraski Ensieh Ghasemian , Rashidi Alimorad 
Published: December 2023

AbstractIn this study, a magnetic perovskite nanohybrid based on g-C3N4 (gCN) nanosheets was synthesized and developed for the efficient photodegradation of toxic environmental pollutants under short-time visible irradiation. The synthesis of this nanohybrid involved the incorporation of SrTiO3:N (STO:N) and ZnFe2O4 (ZnF) onto the g-C3N4 nanosheets through a simple reflux method. Our investigation encompassed a comprehensive suite of analytical techniques, including BET, TGA, TEM, SEM, EDX, DRS, VSM, XRD, photocurrent, and FT-IR, to elucidate the physicochemical characteristics of this nanocomposite in the context of its application in photodegradation processes. The nanohybrid displayed significantly enhanced photocatalytic activity compared to its individual components, achieving a degradation efficiency of over 90% for various pollutants, including organic dyes like Rhodamine B (Rh-B), within a short irradiation time. This enhanced activity can be attributed to the synergistic effect between gCN, STO:N, and ZnF, which promotes the generation of reactive oxygen species and facilitates the degradation process. Notably, the nanocomposite containing 20 wt% STO:N perovskite and 20 wt% ZnF demonstrated the highest Rh-B degradation rate under visible light irradiation within just 30 min. Furthermore, the nanohybrid displayed excellent stability and reusability over seven consecutive runs, retaining its high photocatalytic activity even after multiple cycles of degradation. This remarkable performance can be attributed to the strong interaction between the gCN nanosheets and the magnetic perovskite components, which prevents their aggregation and ensures their efficient utilization. Additionally, the nanohybrid exhibited excellent visible light absorption, enabling the utilization of a wider range of light for degradation. This feature is particularly advantageous, as visible light is more abundant in sunlight compared to UV light, rendering the nanohybrid suitable for practical applications under natural sunlight. In conclusion, the ternary gCN-STO:N@ZnF nanocomposite represents a promising candidate for the treatment of organic pollutants in aqueous environments, offering a versatile and efficient solution.
High frequency oscillations in relation to interictal spikes in predicting postsurgical seizure freedom
Authors: Gerstl Jakob V. E. , Kiseleva Alina , Imbach Lukas , Sarnthein Johannes , Fedele Tommaso 
Published: December 2023

AbstractWe evaluate whether interictal spikes, epileptiform HFOs and their co-occurrence (Spike + HFO) were included in the resection area with respect to seizure outcome. We also characterise the relationship between high frequency oscillations (HFOs) and propagating spikes. We analysed intracranial EEG of 20 patients that underwent resective epilepsy surgery. The co-occurrence of ripples and fast ripples was considered an HFO event; the co-occurrence of an interictal spike and HFO was considered a Spike + HFO event. HFO distribution and spike onset were compared in cases of spike propagation. Accuracy in predicting seizure outcome was 85% for HFO, 60% for Spikes, and 79% for Spike + HFO. Sensitivity was 57% for HFO, 71% for Spikes and 67% for Spikes + HFO. Specificity was 100% for HFO, 54% for Spikes and 85% for Spikes + HFO. In 2/2 patients with spike propagation, the spike onset included the HFO area. Combining interictal spikes with HFO had comparable accuracy to HFO. In patients with propagating spikes, HFO rate was maximal at the onset of spike propagation.
Visualization modality for augmented reality guidance of in‐depth tumour enucleation procedures
Authors: Cattari Nadia , Cutolo Fabrizio , Placa Luciana La , Ferrari Vincenzo 
Published: December 2023

AbstractRecent research studies reported that the employment of wearable augmented reality (AR) systems such as head‐mounted displays for the in situ visualisation of ultrasound (US) images can improve the outcomes of US‐guided biopsies through reduced procedure completion times and improved accuracy. Here, the authors continue in the direction of recent developments and present the first AR system for guiding an in‐depth tumour enucleation procedure under US guidance. The system features an innovative visualisation modality with cutting trajectories that ‘sink’ into the tissue according to the depth reached by the electric scalpel, tracked in real‐time, and a virtual‐to‐virtual alignment between the scalpel's tip and the trajectory. The system has high accuracy in estimating the scalpel's tip position (mean depth error of 0.4 mm and mean radial error of 1.34 mm). Furthermore, we demonstrated with a preliminary user study that our system allowed us to successfully guide an in‐depth tumour enucleation procedure (i.e. preserving the safety margin around the lesion).
Nonpilot directional protection of a microgrid
Authors: Mohammadhassani Ardavan , Mehrizi‐Sani Ali 
Published: December 2023

AbstractProtection of an islanded inverter‐based microgrid is challenging because of variable and small fault current contribution of inverter‐based resources (IBR) and the absence of sequence currents. This paper proposes a fast and robust nonpilot directional protection scheme to address this challenge. This scheme relies on support vector machines (SVM) and the harmonic current injection capability of IBRs. Examining the harmonic currents measured by a relay during a fault shows that harmonic currents have similar magnitudes but different orientation under forward and reverse faults. Additionally, harmonic currents have similar orientation but different magnitudes under forward faults at different locations along the protected line. Using this, six SVMs are trained for each relay, given that there are three main types of faults (three‐phase‐to‐ground, line‐to‐line, and line‐to‐ground): three as directional elements and three as zone detection elements. A fault is detected and classified by the undervoltage element of a relay. Then, the measured harmonic currents are routed to the appropriate directionality and zone detection SVMs to facilitate proper relay coordination. The performance of the proposed method is evaluated on the CIGRE North American MV distribution benchmark system under various types of contingency scenarios using PSCAD/EMTDC software.
Airline revenue management with segmented continuous pricing: methods and competitive effects
Authors: Long Yanbin , Belobaba Peter 
Published: December 2023

AbstractWith the introduction of IATA’s New Distribution Capability (NDC), airlines will no longer be limited to discrete fare classes for their fare product distribution but could show fare quotes from continuous ranges to booking requests. NDC will also allow airlines to present different fare quotes to passengers from different demand segments as identified by the airline. In theory, airlines can better extract passenger willingness to pay, and thus, see gains in revenue, by offering segmented continuous fare quotes to different passengers requesting to book. This paper describes the revenue management (RM) methods for Segmented Continuous Pricing and examines their potential effects on airlines’ revenue through simulations in the Passenger Origin–Destination Simulator (PODS). We describe a class-based algorithm for continuous pricing, a straightforward extension from the traditional methods used with existing RM systems. Our simulation results show that in a calibrated scenario in which only one airline adopts Segmented Continuous Pricing and has an 80% accuracy in identifying business versus leisure passenger booking requests, the first-mover airline can see as much as a 17% revenue gain, at the expense of competitors. The revenue gains come primarily from the leisure passenger segment by offering lower fares than competitors closer to departure. The first-mover airline loses bookings but does not see losses in revenue from the business passenger segment. We also explore potential response strategies by the competing airlines. We discover that competitors can reverse the first-mover’s revenue gain by removing their fare restrictions while still using traditional RM methods. We conclude that although adopting Segmented Continuous Pricing is promising in theory, its gains in practice will depend heavily on the competitive situation and the responses made by competing airlines.
Post-Hyaluronic Acid Recurrent Eyelid Edema: Pathophysiologic Mechanisms and a Proposed Treatment Protocol
Authors: Karlin Justin , Vranis Neil , Dayan Erez , Parsa Kami 
Published: December 2023

Abstract

Background
Hyaluronic acid (HA) filler injections for facial augmentation are commonly administered but can lead to post-hyaluronic acid recurrent eyelid edema (PHAREE). The pathophysiology of this condition has not been fully understood.

Objectives
To report the successful treatment of PHAREE using serial hyaluronidase and fractionated radiofrequency microneedling, with additional carbon dioxide laser skin resurfacing in selected patients.

Methods
Five patients with PHAREE were treated with serial hyaluronidase injections and fractionated radiofrequency microneedling, with 2 patients receiving carbon dioxide laser treatment. The patients were followed up for a minimum of 24 months.

Results
All patients reported a resolution of PHAREE signs/symptoms with no adverse effects or recurrence. One patient demonstrated complete resolution after a single treatment; 4 required a series of treatments.

Conclusions
The proposed treatment protocol may provide advantages over hyaluronidase alone for PHAREE. The impermeable malar septum, vulnerable eyelid lymphatics, and potential immunogenicity of HA fragments likely contribute to PHAREE pathophysiology. Further research on pathophysiologic mechanisms is warranted.

Level of Evidence: 4
Deep learning from atrioventricular plane displacement in patients with Takotsubo syndrome: lighting up the black-box
Authors: Zaman Fahim , Isom Nicholas , Chang Amanda , Wang Yi Grace , Abdelhamid Ahmed , Khan Arooj , Makan Majesh , Abdelghany Mahmoud , Wu Xiaodong , Liu Kan 
Published: December 2023

Abstract

Aims
The spatiotemporal deep convolutional neural network (DCNN) helps reduce echocardiographic readers’ erroneous ‘judgement calls’ on Takotsubo syndrome (TTS). The aim of this study was to improve the interpretability of the spatiotemporal DCNN to discover latent imaging features associated with causative TTS pathophysiology.

Methods and results
We applied gradient-weighted class activation mapping analysis to visualize an established spatiotemporal DCNN based on the echocardiographic videos to differentiate TTS (150 patients) from anterior wall ST-segment elevation myocardial infarction (STEMI, 150 patients). Forty-eight human expert readers interpreted the same echocardiographic videos and prioritized the regions of interest on myocardium for the differentiation. Based on visualization results, we completed optical flow measurement, myocardial strain, and Doppler/tissue Doppler echocardiography studies to investigate regional myocardial temporal dynamics and diastology. While human readers’ visualization predominantly focused on the apex of the heart in TTS patients, the DCNN temporal arm’s saliency visualization was attentive on the base of the heart, particularly at the atrioventricular (AV) plane. Compared with STEMI patients, TTS patients consistently showed weaker peak longitudinal displacement (in pixels) in the basal inferoseptal (systolic: 2.15 ± 1.41 vs. 3.10 ± 1.66, P &lt; 0.001; diastolic: 2.36 ± 1.71 vs. 2.97 ± 1.69, P = 0.004) and basal anterolateral (systolic: 2.70 ± 1.96 vs. 3.44 ± 2.13, P = 0.003; diastolic: 2.73 ± 1.70 vs. 3.45 ± 2.20, P = 0.002) segments, and worse longitudinal myocardial strain in the basal inferoseptal (−8.5 ± 3.8% vs. −9.9 ± 4.1%, P = 0.013) and basal anterolateral (−8.6 ± 4.2% vs. −10.4 ± 4.1%, P = 0.006) segments. Meanwhile, TTS patients showed worse diastolic mechanics than STEMI patients (Eʹ/septal: 5.1 ± 1.2 cm/s vs. 6.3 ± 1.5 cm/s, P &lt; 0.001; Sʹ/septal: 5.8 ± 1.3 cm/s vs. 6.8 ± 1.4 cm/s, P &lt; 0.001; Eʹ/lateral: 6.0 ± 1.4 cm/s vs. 7.9 ± 1.6 cm/s, P &lt; 0.001; Sʹ/lateral: 6.3 ± 1.4 cm/s vs. 7.3 ± 1.5 cm/s, P &lt; 0.001; E/Eʹ: 15.5 ± 5.6 vs. 12.5 ± 3.5, P &lt; 0.001).

Conclusion
The spatiotemporal DCNN saliency visualization helps identify the pattern of myocardial temporal dynamics and navigates the quantification of regional myocardial mechanics. Reduced AV plane displacement in TTS patients likely correlates with impaired diastolic mechanics.
Pharmacogenetic Variation in Neanderthals and Denisovans and Implications for Human Health and Response to Medications
Authors: Wroblewski Tadeusz H , Witt Kelsey E , Lee Seung-been , Malhi Ripan S , Peede David , Huerta-Sánchez Emilia , Villanea Fernando A , Claw Katrina G 
Published: December 2023

Abstract
Modern humans carry both Neanderthal and Denisovan (archaic) genome elements that are part of the human gene pool and affect the life and health of living individuals. The impact of archaic DNA may be particularly evident in pharmacogenes—genes responsible for the processing of exogenous substances such as food, pollutants, and medications—as these can relate to changing environmental effects, and beneficial variants may have been retained as modern humans encountered new environments. However, the health implications and contribution of archaic ancestry in pharmacogenes of modern humans remain understudied. Here, we explore 11 key cytochrome P450 genes (CYP450) involved in 75% of all drug metabolizing reactions in three Neanderthal and one Denisovan individuals and examine archaic introgression in modern human populations. We infer the metabolizing efficiency of these 11 CYP450 genes in archaic individuals and find important predicted phenotypic differences relative to modern human variants. We identify several single nucleotide variants shared between archaic and modern humans in each gene, including some potentially function-altering mutations in archaic CYP450 genes, which may result in altered metabolism in living people carrying these variants. We also identified several variants in the archaic CYP450 genes that are novel and unique to archaic humans as well as one gene, CYP2B6, that shows evidence for a gene duplication found only in Neanderthals and modern Africans. Finally, we highlight CYP2A6, CYP2C9, and CYP2J2, genes which show evidence for archaic introgression into modern humans and posit evolutionary hypotheses that explain their allele frequencies in modern populations.
Differences in olfactory functional connectivity in early-onset depression and late-onset depression
Authors: Chen Ben , Yang Mingfeng , Liu Meiling , Wang Qiang , Zhou Huarong , Zhang Min , Hou Le , Wu Zhangying , Zhang Si , Lin Gaohong , Zhong Xiaomei , Ning Yuping 
Published: December 2023

Abstract

Background
Late-onset depression (LOD) and early-onset depression (EOD) exhibit different pathological mechanisms and clinical phenotypes, including different extents of olfactory dysfunction. However, the brain abnormalities underlying the differences in olfactory dysfunction between EOD and LOD remain unclear.

Objective
The aim of this study was to compare the functional connectivity (FC) patterns of olfactory regions between EOD patients and LOD patients and examine their relationship with cognitive function.

Methods
One hundred and five patients with EOD, 101 patients with LOD and 160 normal controls (NCs) were recruited for the present study. Participants underwent clinical assessment, olfactory testing, cognitive assessments, and magnetic resonance imaging. Eight regions of the primary and secondary olfactory regions were selected to investigate olfactory FC.

Results
Patients with LOD exhibited decreased odor identification (OI) compared with patients with EOD and NCs. The LOD group exhibited decreased FC compared with the EOD and NC groups when primary and secondary olfactory regions were selected as the regions of interest (the piriform cortex, lateral entorhinal cortex, and orbital-frontal cortex). Additionally, these abnormal olfactory FCs were associated with decreased cognitive function scores and OI, and the FC between the left orbital-frontal cortex and left amygdala was a partial mediator of the relationship between global cognitive scores and OI.

Conclusion
Overall, patients with LOD exhibited decreased FC in both the primary and secondary olfactory cortices compared with patients with EOD, and abnormal olfactory FC was associated with OI dysfunction and cognitive impairment. The FC between the orbital-frontal cortex and amygdala mediated the relationship between global cognitive function and OI.
PERCHING syndrome caused by variant gene KLHL7 in the first Iranian patient: a case report study
Authors: Ghelichi-Ghojogh Mousa , Golfiroozi Saeed , Delavari Sahar , Hosseini Seyed Ahmad 
Published: December 2023

Introduction and importance:
PERCHING syndrome is a condition that affects many parts of the body and is caused by genes passed down from both parents. People with this syndrome have delays in their development, unusual facial features, trouble eating and breathing, slow overall growth, weak muscles, and stiff joints.

Case presentation:
The child at the age of 6 months suffered from developmental delay, delayed walking, speech delay, and hypotonia and was referred to the Neurologist. Also, he has an abnormal phenotype. Whole-exome sequencing (WES) revealed a missense variant in the KLHL7 gene at a highly conserved genomic Chr7: 23124718T>G; NM_018846:exon3:c.110T>G:p.Val37Gly.

Clinical discussion:
One way to explain the difference in physical characteristics caused by recessive KLHL7 mutations might be related to the person’s genetic makeup. However, the genes someone has do not always accurately determine their physical traits.

Conclusion:
This report will help us learn more about the different traits and characteristics of Perching syndrome. The authors need to do more research on how proteins work and study more about patients with different characteristics to fully understand this.