bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sharps injuries within the healthcare student population: a narrative review
Authors: Hambridge Kevin 
Published: December 2023

Background: Studies have reported evidence on sharps injuries among nursing, medical and dental students but little is known about the amount, type and causes of sharps injuries affecting other healthcare students. Aim: The aim of the narrative review was to identify the extent, type and causes of sharps injuries sustained by healthcare students, especially those not in those fields. Method: Eight databases were searched using keywords to identify studies published between 1980 and March 2023. Findings: This narrative review highlights that some groups of healthcare students, including those studying pharmacy, physiotherapy and radiography, sustain sharps injuries from similar devices as reported in research on such injuries in nursing, medical and nursing students. Sharps injuries happen in a range of healthcare environments, and many were not reported by students. The main cause of a sharps injury identified was a lack of knowledge. Conclusion: More research is needed on the extent of sharps injuries in healthcare students in European countries and the UK as well as on their physical and psychological effects. Education and training in sharps use and disposal are essential.
Analýza území pomocí prostorových datasetů
Authors: Kliment Daniel 
Published: December 2023

Příspěvek zaměřen na zkoumání závislost geolokačních dat a cenových údajů na prostorových charakteristikách území v jednotlivých urbanistických strukturách. Datová sada prostorových charakteristik území byla získána z OpenStreetMap jako zdroje informací pro popis a rozbor území urbanistické struktury. Každá urbanistická struktura (typologie) ve městě má své vlastnosti dané charakterem veřejných prostranství, měřítkem staveb, vzájemnými vazbami a atmosférou. Pro potřeby srovnání sledovaných vybraných statistických dat jsem urbanistickou strukturu města Brna rozdělil do několika základních typů: kompaktní struktura, bloková struktura, smíšená struktura, novodobé obytné soubory, solitérní vily a rodinné domy. Pro vyhodnocení byla použita metoda Multiple-sample comparison, konkrétně analýza rozptylu (ANOVA). Analýza interakce mezi obyvateli a městským prostorem může pomoci ke správnému usměrnění tvorby životního prostředí a souvisejícího veřejného prostoru. Přínos spočívá v ukázce inovativního přístupu ke sběru a využití informací pomocí otevřených prostorových dat prostřednictvím datových platforem.
Acknowledging the impact of seasonal blood pressure variation in hypertensive CKD and non-CKD patients living in a Mediterranean climate
Authors: Charbel Tatiana , El Koubayati Georgio , Kharsa Chloe , Aoun Mabel 
Published: December 2023

Background
This study aims to assess seasonal blood pressure (BP) variation in chronic kidney disease (CKD) and non-CKD patients living in a Mediterranean climate, and to find out if this variation entails significant adjustment of treatment and if it impacts renal outcomes and mortality.

Methods
This retrospective study included all hypertensive patients seen between February 2006 and April 2020 in two Lebanese clinics. Regression analyses were used to assess the association of seasonal BP variability and treatment adjustment with eGFR change from baseline, dialysis initiation and death.

Results
A total of 398 patients of 64.2 ±13.9 years were followed for 51.1 ±44.3 months, 67% had eGFR< 60 mL/min. Mean systolic and diastolic BP was 137.7 ±14.7 and 76.5 ±9.5 mmHg respectively. Systolic and diastolic BP were significantly lower in the warm season in CKD and non-CKD patients (P<0.001). The majority (91.4%) needed seasonal treatment modifications. After adjustment to age, sex, baseline eGFR, BP and number of antihypertensive drugs, we found a significant loss of eGFR with treatment modifications in both seasons, double risk of dialysis with the increase of antihypertensive treatment in both seasons and a 2.5 more risk of death with reduced treatment in the warm season.

Conclusion
This study confirmed the seasonal BP variability in CKD and non-CKD patients from a Mediterranean climate. All types of treatment adjustment were associated with eGFR loss. Low BP in the warm season was highly associated with death.
Which body functions and activities matter for stroke patients? Study protocol for best–Worst scalings to value core elements of the International Classification of Functioning, Disability and Health
Authors: Juhnke Christin , Mühlbacher Axel Christian 
Published: December 2023

Background
Stroke is a common, serious, and disabling healthcare problem with increasing incidence and prevalence. Following a stroke, identifying the factors associated with decisions about rehabilitation interventions is important to assess rehabilitation after stroke. The aim is to guide clinical staff to make patient-centered decisions. Fundamentally, decision makers cannot draw on evidence to consider the relevance of distinct functions and activities from the patient’s perspective. Until now, outcomes of rehabilitation are generally categorized using the International Classification of Functioning, Disability and Health (ICF). This can be seen as a conceptual basis for the assessment of health and disability. Since the ICF does not distinguish importance between these aspects there is a need to value the most important clinical factors as well as related activities from a patients and public perspective to help guide therapists in effectively designing post-acute rehabilitation care for individuals following stroke. The research question is which ICF body functions and activities are of value to stroke patients? Which trade-offs are patients willing to make within the core elements? Health preference research (HPR) answers the need to develop additional preference weights for certain ICF dimensions. Patient preference information (PPI) values health conditions based on the ICF from a patient perspective.

Methods
In this study we conduct three best–worst scaling (BWS) experiments to value body function and activities from patients’ and public perspective. Out of all ICF dimensions this research covers health conditions relevant to stroke patients in terms of body function, perception, and activities of daily living. Stroke patients as well as members of the general population will be recruited to participate in the online BWS surveys. Fractional, efficient designs are applied regarding the survey design. Conditional and multinominal logit analyses will be used as the main analysis method, with the best–worst count analysis as a secondary analysis. The survey is being piloted prior to commencing the process of data collection. Results are expected by the autumn of 2023.

Discussion
The research will add to the current literature on clinical decision-making in stroke rehabilitation and the value of certain body functions as well as related activities in neurorehabilitation. Moreover, the study will show whether body functions and activities that are currently equally weighted in international guidelines are also equally important from the point of view of those affected, or whether there are disconcordances in terms of differences between public judgements and patients’ preferences.
Gender and the length of time since autologous hematopoietic stem cell transplantation—What is their influence on the immune reconstitution in multiple myeloma patients?
Authors: Popierz-Rydlewska Natalia , Merkiel-Pawłowska Sylwia , Łojko-Dankowska Anna , Komarnicki Mieczysław , Chalcarz Wojciech 
Published: December 2023

Introduction
In the literature there is lack of information on the influence of gender and time since autologous hematopoietic stem cell transplantation (HSCT) on the immune reconstitution in multiple myeloma (MM) patients.

Objective
The aim of this study was to assess the diversity of the immune reconstitution according to gender in MM patients after autologous HSCT on the day of the clinic discharge and on the 29th day after discharge, as well as to investigate the changes in the immune system in females and males after staying at home for 28 days.

Method
The studied population comprised 13 females and 13 males after autologous HSCT. On the day of the clinic discharge and on the 29th day after discharge blood samples were taken to analyse 22 immunological parameters. Statistical analysis was performed using STATISTICA 10 StatSoft Poland. For multiple comparisons, the Bonferroni correction was used.

Results
No statistically significant differences were observed in the analysed immunological parameters between the studied females and males with MM on the day of the clinic discharge and on the 29th day after discharge. However, on the 29th day after the clinic discharge compared to the day of the clinic discharge, statistically significant differences were found in 8 immunological parameters among females and 6 immunological parameters among males.

Conclusion and recommendation
Our results indicate that the immune reconstitution is similar but not the same in patients of both genders. Statistically significant differences in the immune response in the studied females and males imply that gender may play a role in the immune reconstitution and that the results obtained in MM patients should be analysed separately in females and males. In order to explain the observed changes in the immune system according to gender, further research should be carried out on a larger population. This would most probably make it possible to find their clinical application.
Association between glucose-to-lymphocyte ratio and in-hospital mortality in acute myocardial infarction patients
Authors: Liu Jing , Hu Xiaogang 
Published: December 2023

Background
Inflammation is involved in the development and progression of atherosclerosis. Recent studies indicated that glucose-to-lymphocyte ratio (GLR) level were significantly associated with the risk of mortality from inflammatory diseases, and showed a specific prognostic value. Herein, this study intended to explore the association between GLR level and in-hospital mortality in patients with acute myocardial infarction (AMI), and evaluate the predictive value of GLR on AMI prognosis.

Methods
Data of patients with AMI were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database in 2012–2019 in this retrospective cohort study. Univariate COX proportional hazard model was used to screen covariates. The associations between GLR and in-hospital mortality were evaluated using univariate and multivariate COX proportional hazard models. Subgroup analysis of age, gender, vasopressor use, SOFA scores, renal replacement therapy, coronary artery bypass graft, and β blockers use were performed. The evaluated index was hazard ratios (HRs) and 95% confidence intervals (CIs). In addition, the predictive performance of GLR, glucose, and lymphocytes on in-hospital mortality was assessed respectively.

Results
Among eligible patients, 248 (13.74%) died in the hospital. After adjusting for covariates, we found that a higher GLR level was associated with an increased risk of in-hospital mortality [HR = 1.70, 95%CI: (1.24–2.34)]. This relationship was also found in patients who were male, aged ≥65 years old, did not have renal replacement therapy, coronary artery bypass graft, or β blockers, used vasopressor or not, and whatever the SOFA scores (all P<0.05). Moreover, the predictive performance of GLR on in-hospital mortality seemed superior to that of glucose or lymphocytes.

Conclusion
GLR may be a potential predictor for AMI prognosis, which provided some references for identifying and managing high-risk populations early in clinical.
Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis
Authors: Cheng Zhengyuan , Zhang Xiaojuan , Chen Pingsheng , Wang Haitao , Wang Kuangjing , Shen Yingzhou 
Published: December 2023

Abstract
Liver fibrosis is a type of chronic pathological liver damage involving liver tissue hypoxia and abnormal extracellular matrix deposits. Hepatic stellate cells (HSCs) activation is critical for liver fibrosis. Currently, inhibiting HSCs activation or inducing HSCs ferroptosis is considered an effective strategy for the treatment of liver fibrosis. Sarcoma protein kinase (Src) is an important member of the tyrosine protein kinase family. Hypoxia causes Src phosphorylation at tyrosine 416 (Tyr 416), and inhibiting Src activation can alleviate liver fibrosis. There is currently little research on the relationship between Src activation and ferroptosis in liver fibrosis. 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (PP1) is an inhibitor of Src activation at Tyr 416. Therefore, in this study we treated HSC-T6 cells with PP1 under normoxic and hypoxic culture conditions; moreover, PP1 was also used to treat a carbon tetrachloride-induced mouse liver fibrosis model. We explored whether inhibiting Src activation could alleviate liver fibrosis by promoting HSCs ferroptosis in vitro and in vivo. In vitro experiments showed that inhibiting Src activation in HSC-T6 cells significantly reduced hypoxia-inducible factor-1α (HIF-1α) expression and HSC-T6 cells activation, and ferroptosis was significantly increased. In vivo experiments revealed that inhibiting Src activation in fibrotic livers reduced HIF-1α expression; meanwhile, ferroptosis was promoted, and liver fibrosis was alleviated. Therefore, inhibiting Src activation, which increases HSCs ferroptosis, can alleviate liver fibrosis.
Clinical features and management of lymphoepithelial cyst
Authors: Cui Ning , Su Wenhao , Zhang Jixiang , Zhou Zhongyin 
Published: December 2023

Abstract
The aim of the study was to analyze clinical features of lymphoepithelial cyst (LEC) to make a more comprehensive and deeper understanding of it. We retrospectively analyzed the hospital records of 201 patients who were diagnosed by pathology results. Clinical characteristics like demographic profiles, lesion characteristics, therapeutic schedule, and associated costs were analyzed. Patient’s age ranged from 17 to 83 years old (52.6 ± 14.3, 120 males and 81 females). There were 12 cases of pancreatic LEC, 48 of oral LEC, and 141 of parotid LEC. Single lesion was found to be more than multiple lesions (147:54, 73.1%:26.9%). The majority of patients was primarily diagnosed by imaging test and endoscopy (171, 85.1%). All patients were finally confirmed by pathology results. Different treatment plans were selected according to personal situation, including dynamic observation (21, 10.5%), non-surgical treatment (24, 11.9%), and surgical treatment (156, 77.6%). No recurrence was found in surgical treatment patients for up to 24 months follow-up. To sum up, LEC is a rare and benign lesion, which is mostly located at parotid and oral, rarely located at pancreas. No typical symptoms could be found. EUS-FNA could be a reliable way to obtain pathological diagnosis. LEC could be cured by surgical resection with no recurrence.
Homoclinic breather, periodic wave, lump solution, and M-shaped rational solutions for cold bosonic atoms in a zig-zag optical lattice
Authors: Rizvi Syed T. R. , Seadawy Aly R. , Ahmed Samia 
Published: December 2023

Abstract
In this article, the equation showing the cold bosonic atoms in a zig-zag optical lattice model for some breathers, M-shaped solution and lump soliton solution, homoclinic breather pulses, breather lump pulses, periodic-cross kink wave, kink cross-rational propagation, and interaction between lump periodic and kink wave was examined. Some M-shaped solution, M-shaped interaction with periodic and kink, M-shaped interaction with rogue and kink, M-shaped rational solution, M-shaped rational solution with one kink, M-shaped rational solution with two kink, solutions for lump soliton waves, lump one kink waves, lump two kink waves, periodic-cross lump wave propagation, periodic wave propagation, rogue wave propagation, and multiwave propagation were also acquired. Likewise, our solution was also graphically presented, and also their stability was checked.
Recovery of wipe sampling of urban surfaces contaminated with blistering chemical warfare agents
Authors: Rozsypal Tomáš , Nekvinda Václav 
Published: December 2023

Abstract
Effective sampling is a key step in the process of proving the use of chemical weapons. An alternative to collecting the respective sample is to perform a wipe of surface contamination. This work deals with the optimization of the wiping process of the surfaces of selected matrices contaminated with bis(2-chloroethyl)sulfide and tris(2-chloroethyl)amine. Optimization of the procedure was carried out in terms of the choice of wiping material, wetting solvent and extraction of the wiped contaminant. Furthermore, the time decrease of surface contamination was monitored. The effect of transport on the change in the observed recovery value was investigated and the measurement deviations of the wipe method were discussed. The resulting values of observed recovery were negatively influenced by the volatility of the analyte, the porosity of the matrix and the time that passed since the contamination. Viscose was evaluated as the most effective wipe material. Low relative standard deviations (≤7 %) were achieved with this material. The optimal wetting solvent was dichloromethane. There was no degradation of contaminants on the surface of the matrices, so the fate was only affected by evaporation and penetration into the material.
Multi-perspective structural integrity-based computational investigations on airframe of Gyrodyne-configured multi-rotor UAV through coupled CFD and FEA approaches for various lightweight sandwich composites and alloys
Authors: Vijayalakshmi Selvaramanan , Sekar Aravindha Vasan , Hassan Ahmed Mohamed , Arputharaj Beena Stanislaus , Jayakumar Shyam Sundar , AL-bonsrulah Hussein A. Z. , Rajendran Parvathy , Madasamy Senthil Kumar , Karuppasamy Arunkumar , Raja Vijayanandh 
Published: December 2023

Abstract
As this unmanned aerial vehicle (UAV) has a planned airframe that can carry a 25 kg payload, understanding its structural capabilities, such as its compressive and tensile strengths under different situations, is essential. For the purpose of comprehending the fluid–structure interaction (FSI) of the fuselage, this study designs and analyses the lightweight materials used in the airframe of a complex Gyrodyne UAV. A computer model of a composite airframe for a Gyrodyne UAV is built to examine its durability. An essential factor in the aircraft business is minimizing unnecessary weight, and this FSI study emphasizes the importance of sandwiches and their hybrid combinations in this regard. After the material finalization, around 140 material combinations are tested using an advanced computational composite platform, in which four different lightweight material families are implemented. The fluid load (pressure) is imported into ANSYS workbench 17.2, and the structural airframe is then solved according to the boundary conditions of the application domain. Also, experimental experiments using the high-speed jet facility are run to verify computational improvements. Materials for the airframe of the Gyrodyne UAV have been narrowed down to a final list of contenders. As the work focuses on the FSI analysis, not much computational fluid dynamics (CFD) results were discussed here. Only the imported pressure from the CFD analysis was imposed on to the Gyrodyne UAV to proceed for the FSI analysis.
cinq façons de faire la promotion de votre cabinet
Authors: Khan Mohammad 
Published: December 2023

Vous avez travaillé fort pour mettre sur pied votre cabinet et le temps est venu de présenter le fruit de votre labeur au public. L’établissement d’une patientèle est un long cheminement, mais la mise en œuvre de différentes stratégies de marketing est souvent le coup de pouce dont vous avez besoin pour commencer à positionner votre cabinet dans l’univers du marketing.
Vos patients doivent savoir ce qui se passe dans votre cabinet et si vous avez de nouveaux services ou produits, des éléments qui doivent être au cœur de toutes vos démarches de marketing. Voici les cinq façons de faire la promotion de votre cabinet.
Procédures cliniques : Un nouveau test pour examiner les différentes composantes de la réfraction monoculaire subjective
Authors: Shapiro Jonathon 
Published: December 2023

Importance : La réfraction monoculaire subjective constitue l’examen de base pour déterminer la puissance d’une lentille ophtalmique. L’utilisation d’un seul outil d’examen pour déterminer la prescription finale, simultanément avec une méthode de contrôle des erreurs d’examen, simplifie la procédure, puisque le patient a maintenant une meilleure compréhension de l’objectif et se sent plus à l’aise avec l’examen.

But L’objectif de cette étude était de mettre au point un tableau d’examen et une méthode d’examen permettant d’améliorer l’efficacité de la détermination de la correction des composantes astigmatiques et sphériques d’une prescription. La procédure de test utilise une comparaison immédiate et évite les tests séquentiels qui dépendent de la mémoire.
Elle comporte une méthode permettant d’éviter les erreurs causées par le décentrement.
Ceci est important dans le cas de prescriptions élevées. Cette méthode peut être utilisée par le personnel auxiliaire dans le cadre des tests préliminaires.
Méthodes : Un tableau d’examen unique et non mobile indépendant du cercle de moindre confusion est présenté. La cible est basée sur la résolution simultanée d’une ligne dans quatre méridiens. Un deuxième tableau est intégré au tableau principal. Il utilise le déplacement chromatique, causé par l’observation décentrée d’un prisme, pour éviter les erreurs.
Résultats : Il a été démontré que cette méthode d’essai, lorsqu’elle est utilisée à la clinique, est efficace et facile à comprendre. Un essai indépendant limité a montré que la méthode est aussi efficace que les méthodes traditionnelles et donne des résultats acceptables lorsqu’elle est utilisée par le personnel auxiliaire. Les résultats obtenus par des personnes sans expérience sont également présentés. Cela peut être utile dans les environnements où il n’y a pas de personnel professionnel disponible.
Conclusion : La méthode décrite ici améliore l’examen de la réfraction subjective sans avoir à changer de cible. Il n’est pas nécessaire de tenir compte du cercle de moindre confusion. La cible comprend des tests pour l’axe, la puissance du cylindre, la puissance sphérique et le duochrome. Les patients préfèrent la comparaison simultanée au test séquentiel et la comprennent facilement. Le point final sphérique est défini, sauf en cas d’hyperacuité ou de spasme d’accommodation. Le test améliore la capacité du patient à comprendre la méthode d’examen et à se sentir à l’aise. L’équilibre binoculaire n’est pas pris en compte ici.