bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet function in acute experimental pancreatitis induced by ischaemia–reperfusion
Authors: Hackert T , Pfeil D , Hartwig W , Gebhard M M , Büchler M W , Werner J 
Published: April 2005

Abstract

Background
Ischaemia–reperfusion (IR)-associated microcirculatory changes play a major role in acute post-transplantation pancreatitis. The pathophysiological role of platelets in these events is unknown. The aim of this study was to examine platelet adhesion and function during early reperfusion after pancreatic ischaemia.

Methods
Rats were subjected to warm pancreatic ischaemia by cross-clamping of the pancreatic vessels for 1 h. After 1 h of reperfusion, platelet–endothelium interaction was evaluated after platelet separation and staining by fluorescence microscopy. Amylase levels and pancreatic histology were evaluated 24 h after reperfusion. Animals treated according to an identical protocol, but without ischaemia, served as controls.

Results
Mild pancreatitis had developed by 24 h after IR; serum amylase levels were significantly higher than those in control animals. The numbers of adherent platelets in capillaries and venules were significantly increased, and platelet velocity in capillaries was significantly decreased, in the IR group compared with controls. There was significantly more oedema and inflammation in pancreatic tissue after IR.

Conclusion
Warm ischaemia for 1 h followed by reperfusion for 24 h caused mild pancreatitis in this experimental model. The pancreatic microcirculation was characterized by pronounced platelet–endothelium interaction in capillaries and venules. These results suggest that platelet activation may play an important role in acute post-transplantation pancreatitis.
Numerical study of influences of buoyancy and solutal Marangoni convection on flow structures in a germanium‐silicon floating zone
Authors: Lin K. , Dold P. , Benz K. W. 
Published: April 2005

AbstractThis paper presents a numerical study of Marangoni flows in a floating zone of germanium‐silicon crystals, which was performed by using a commercial finite element program FIDADTM. The numerical results point out that for fluids with a small Pr number the influence of buoyancy forces cannot be ignored in the numerical model. Furthermore, the competition between the thermocapillary (TC) and solutocapillary (SC) flows in the floating zones was qualitatively examined. If the TC flow is as strong as that in the Si‐rich floating zone, the SC flow may be restricted to the bottom area near the free surface. Otherwise, the SC flow may overcome the TC flow and induce a surface transfer of species. The numerical predictions agree well with the previous experiment results. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Manifestation of microcrystalline structure in transport properties of p‐quinquophenyl films
Authors: Tkaczyk S. , Kityk I. V. , Ebothé J. 
Published: April 2005

AbstractThe electrical conductivity measurements of the p‐quinquephenyl films possessing microcrystallite structure are done at temperature between 10 K–300 K. The investigated film thickness varies within 0.2–2.5 µm. The measurements were performed with Al(Au) electrodes for the films deposited by spin coating in argon atmosphere on glass substrates. The molecular dynamics simulations as well as quantum chemical calculations have shown that three different mechanisms contribute to the observed electrical feature, which are: the conductivity originated from proper crystalline states; this of the amorphous‐like inter‐grain region and the one created in the grain boarder interfaces. Comparing the experimental data and theoretically calculated dependencies, we have shown that the main contribution to the observed DC conductivity of this material results from the interfaces located at the borders of polycrystalline grains, although they possess a relatively low part of the total film volume. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Crystal structures of N1, N5‐dibenzoyltetrahydro‐4‐methyl‐1, 5‐benzodiazepin‐2‐one (DBTBO) and tetrahydro‐4‐methyl‐1, 5‐benzodiazepin‐2‐one (TBO)
Authors: Nallini A. , Saraboji K. , Ponnuswamy M. N. , Venkatraj M. , Jeyaraman R. 
Published: April 2005

AbstractAdducing structural analogies between the two fused systems, N1, N5‐Dibenzoyltetrahydro‐4‐methyl‐1,5‐benzodiazepin‐2‐one, C24H20N2O3 (DBTBO CCDC 200341) and Tetrahydro‐4‐methyl‐1,5‐benzodiazepin‐2‐one, C10H12 N2O (TBO CCDC 200342) helps to find the pharmacological differences from the view point of variant hetero atom substitutions in the hetero cycle. Both the diazepines crystallized in identical monoclinic space group P21/n with a = 14.1134(1) Å, b = 9.2444(1) Å, c = 16.3812(1) Å; β = 107.11(1)º, V = 2042.7(3) Å3 for DBTBO and a = 9.3363(7) Å, b = 10.4895(8) Å, c = 9.9852(7) Å, β = 91.314(1)º, V = 977.62(1) Å3 for TBO, respectively. The two structures were solved by direct methods and refined by full‐matrix least‐squares procedure to final R‐values of R1 = 0.0575(DBTBO) and R1 = 0.0984(TBO). Structural differences include non‐identical boat conformations of these seven‐membered rings and the different non‐bonding interactions in the benzodiazepine pair.
Crystal structure and conformational analyses of a synthetic tetrapeptide t‐Boc‐L‐Val‐Aib‐Gly‐L‐Leu‐OMe
Authors: Singh Rathore Ravindranath 
Published: April 2005

AbstractCrystal structure of a terminally blocked synthetic peptide, t‐Boc‐L‐Val‐Aib‐Gly‐L‐Leu‐OMe has been investigated. Two different conformers of peptide with one co‐crystallized water molecule, coexist in the crystal structure, in C2 space group. Both the conformers are stabilized by two intramolecular 1← 4 hydrogen bonds, between (Boc) C=O … HN (Gly) and (Val) C=O … HN (Leu), forming consecutive type II‐I' β‐turns. In the crystal, water interlinks peptide molecules, making a triangular bridge of pyramidal type. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Virtual datalink emulation and protocol development
Authors: Imaizumi Hideaki , Sugiura Kazunori , Murai Jun 
Published: April 2005

AbstractIn this paper, we propose and discuss a method for achieving expandability and portability through the protocol specifications and implementation of a virtual network. Technologies based on graph abstractions such as link‐state routing and broadcast techniques do not fundamentally depend on specific network technologies. Today, in order for these technologies to directly use the identifiers and communication protocols defined by a specific network technology, portability to other network technologies and adaptability to a heterogeneous network environment are degraded. The portability and adaptability to a heterogeneous network environment are improved by designing and implementing these technologies for a virtual network and emulating the virtual network on various networks. In this paper, to construct a virtual network, we explain a method for emulating the virtual datalink ANCIF proposing the same media access control protocol and protocol development using ANCIF. In practice, we applied and implemented ANCIF on various real networks, and measured the protocol overhead resulting from the virtual implementation. The result was extremely small overhead and almost no effect on performance. Finally, we discuss the portability to other network technologies and the adaptability to a heterogeneous network environment which are obtained by applying ANCIF. © 2005 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 88(8): 32–40, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.10204
Essential oil composition of Artemisia fragrans Willd. from Iran
Authors: Morteza‐Semnani Katayoun , Akbarzadeh Mohammad , Moshiri Kamran 
Published: April 2005

AbstractThe composition of the essential oil obtained from the dried ﬂowering aerial parts of Artemisia fragrans Willd. (Compositae) was analysed by GC and GC–MS for the ﬁrst time. Twenty‐seven components were identiﬁed in the essential oil of A. fragrans, whose major constituents were camphor (46.0%), 1,8‐cineole (23.7%) and camphene (7.9%). Copyright © 2004 John Wiley & Sons, Ltd.
Characterizing allelic associations from unphased diploid data by graphical modeling
Authors: Thomas Alun 
Published: April 2005

AbstractA method for estimating a graphical model to describe allelic associations between genetic loci is extended to use diploid genotypes rather than haploid data. It also provides haplotype frequency estimates, estimates of phase for sampled individuals, allows for missing or partial information, genotyping errors, and arbitrary penetrance functions. A data set of 688 unrelated individuals genotyped on 25 genetic loci is used to illustrate haplotype frequency estimation. The frequencies obtained are shown to be similar to those obtained by the PHASE program. We also illustrate how putative loci for traits can be included in the analysis in order to detect allele‐phenotype associations. Haplotype reconstruction is illustrated on a standard set of 40 male X‐chromosome haplotypes, randomly paired to simulate diploid genotype data. The novel method is shown to be comparable to most existing ones, though the PHASE method does consistently better on this problem. The graphical model approach is shown to have some advantages in terms of tractability and can be used to select informative subsets of loci and to map loci influencing phenotypes.Genet. Epidemiol.© 2005 Wiley‐Liss, Inc.
System access hotspots: Are auditors ignoring danger?
Authors: Tyson Susan , Bean LuAnn 
Published: April 2005

AbstractA recent survey found that only 54 percent of internal audit departments think information technology general controls are a critical part of complying with Sarbanes‐Oxley (SOX) Section 404. But management can't determine how effective its internal controls are without an in‐depth investigation of systems access security. Some internal auditors may be ignoring a lurking danger. So, the authors give detailed advice on how to secure hazardous system access hotspots. © 2005 Wiley Periodicals, Inc.
Ethics: Difficult questions, unpopular answers
Authors: Burton Eric James 
Published: April 2005

AbstractDiscussing and studying ethics is the “in” thing right now. There is a blizzard of reports, courses, news stories, and debates. But what's the bottom line? The author cuts through the confusion, saying there are several key questions we have to answer. This article examines the issues and shows what to do in a clear, thoughtful way. © 2005 Wiley Periodicals, Inc.
The risks of “paperless” bank checks
Authors: DeVries Delwyn D. , Kiger Jack E. 
Published: April 2005

AbstractAre your auditors ready for the latest electronic revolution—Check 21? The Check Clearing for the 21st Century Act (Check 21) hastens the use of substitute bank checks. The substitutes consist of an electronic image of the front and back of checks presented for payment. And neither banks nor the disbursing party can require return of an original (paper) check. What risks do companies face from this “paperless” system? What new internal controls must firms establish? And since auditors won't be able to use paper checks as evidence of payment, what will they do? © 2005 Wiley Periodicals, Inc.
Sarbanes‐Oxley update: Where are we today?
Authors: Rouse Robert W. , Weirich Thomas R. , Hambleton Wendy M. 
Published: April 2005

AbstractIt has been over two years since Congress passed the Sarbanes‐Oxley Act (SOX) in an effort to restore investor confidence in the financial reporting of publicly held companies. So what has really changed? What is the situation today? The authors examine the aftermath of SOX and the latest guidance for companies struggling to comply. © 2005 Wiley Periodicals, Inc.
XRCC1 and DNA polymerase β interaction contributes to cellular alkylating‐agent resistance and single‐strand break repair
Authors: Wong Heng‐Kuan , Wilson David M. 
Published: April 2005

AbstractX‐ray cross complementing 1 (XRCC1) protein has been suggested to bind to DNA single‐strand breaks (SSBs) and organize protein interactions that facilitate efficient DNA repair. Using four site‐specifically modified human XRCC1 mutant expression systems and functional complementation assays in Chinese hamster ovary (CHO) XRCC1‐deficient EM9 cells, we evaluated the cellular contributions of XRCC1s proposed N‐terminal domain (NTD) DNA binding and DNA polymerase β (POLβ) interaction activities. Results within demonstrate that the interaction with POLβ is biologically important for alkylating agent resistance and SSB repair, whereas the proposed DNA binding function is not critical to these phenotypes. Our data favor a model where the interaction of XRCC1 with POLβ contributes to efficient DNA repair in vivo, whereas its interactions with target DNA is biologically less relevant. Published 2005 Wiley‐Liss, Inc.
Proteomic analysis of differential protein expression in response to epidermal growth factor in neonatal porcine pancreatic cell monolayers
Authors: Hong Oak‐Kee , Suh Sun‐Hee , Kwon Hyuk‐Sang , Ko Seung‐Hyun , Choi Yoon‐Hee , Moon Sung‐Dae , Yoo Soon‐Jib , Son Ho‐Young , Park Kyung‐Soo , Lee In‐Kyu , Yoon Kun‐Ho 
Published: April 2005

AbstractWe have proposed that porcine neonatal pancreatic cell clusters (NPCCs) may be a useful alternative source of cells for islet transplantation, and that monolayer cultures might provide an opportunity to manipulate the cells before transplantation. In addition we previously identified 10 genes up‐regulated by epidermal growth factor (EGF) in cultured porcine NPCC monolayers. We have now analyzed the intracellular signaling pathways activated by EGF and searched for proteins differentially expressed following EGF treatment of the monolayers, using two‐dimensional gel electrophoresis (2‐DE) and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS). EGF treatment resulted in phosphorylation of both Erk 1/2 and Akt, as well as increased cell proliferation. Five unknown and 13 previously identified proteins were differentially expressed in response to EGF. EGF treatment increased the expression of several structural proteins of epithelial cells, such as cytokeratin 19 and plakoglobin, whereas vimentin, the intermediate filament protein of mesenchymal cells, and non‐muscle myosin alkali chain isoform 1, decreased. Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 factor, which promotes epithelial cell proliferation, and hemoglobin alpha I & II also increased, whereas cyclin A1, immunoglobulin heavy chain, apolipoprotein A1, 5,10‐ethylenetetrahydrofolated reductase (5,10‐MTHFR), angiotensin‐converting enzyme 2 (ACE2), co‐lipase II precursor, and NAD+ isocitrate dehydrogenase (NAD+ IDH) alpha chain proteins decreased. Our results show that EGF stimulates proliferation of pancreatic epithelial cells by simultaneously activating the MAPK and PI‐3K pathways. HnRNP A2/B1, hemoglobin, cyclin A1, and ACE2 may play roles in the proliferation of epithelial cells in response to EGF. © 2005 Wiley‐Liss, Inc.
Syntheses of [14C] and [2H4]PD0205520, an inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor
Authors: Zhang Yinsheng , Huang Yun , Huang Che C. 
Published: April 2005

Abstract5‐(4‐Methyl‐piperazin‐1‐yl)‐pent‐2‐ynoic acid [4‐(3‐chloro‐4‐fluoro‐phenylamino)‐pyrido[3,4‐d]pyrimidin‐6‐yl]‐amide, PD0205520, was under investigation as a potential inhibitor of the tyrosine kinase (TK) activity of the epidermal growth factor receptor (EGFR) for cancer treatment. Both radio‐ and stable‐isotope‐labeled compounds were required for drug absorption, distribution, metabolism and excretion (ADME) and quantitative mass spectrometry bio‐analytical studies. PD0205520 I4C‐labeled in the pyrimidine ring system was prepared in seven steps in an overall radiochemical yield of 26% from [14C]thiourea. PD0205520 2H‐Iabeled in the piperazine ring was synthesized in four steps in a 32% overall yield. Copyright © 2005 John Wiley & Sons, Ltd.
Batoid wing skeletal structure: Novel morphologies, mechanical implications, and phylogenetic patterns
Authors: Schaefer Justin T. , Summers Adam P. 
Published: April 2005

AbstractThe skeleton of the “wings” of skates and rays consists of a series of radially oriented cartilaginous fin rays emanating from a modified pectoral girdle. Each fin ray consists of small, laterally oriented skeletal elements, radials, traditionally represented as simple cylindrical building blocks. High‐resolution radiography reveals the pattern of calcification in batoid wing elements, and their organization within the fin ray, to be considerably more complex and phylogenetically variable than previously thought. Calcification patterns of radials varied between families, as well as within individual pectoral fins. Oscillatory swimmers show structural interconnections between fin rays in central areas of the wing. Morphological variation was strongly predictive of locomotor strategy, which we attribute to oscillatory swimmers needing different areas of the wing stiffened than do undulatory swimmers. Contributions of various forms of calcification to radial stiffness were calculated theoretically. Results indicate that radials completely covered by mineralized tissue (“crustal calcification”) were stiffer than those that were calcified in chain‐like patterns (“catenated calcification”). Mapping this functionally important variation onto a phylogeny reveals a more complicated pattern than the literature suggests for the evolution of locomotor mode. Therefore, further investigation into the phylogenetic distribution of swimming mode is warranted. J. Morphol. © 2005 Wiley‐Liss, Inc.
Miniaturized system of a gas chromatograph coupled with a Paul ion trap mass spectrometer B. J. Shortt, M. R. Darrach, Paul M. Holland and A. Chutjian Journal of Mass Spectrometry 2005; 40: 36–42
Authors: Shortt B. J. , Darrach M. R. , Holland Paul M. , Chutjian A. 
Published: April 2005

AbstractThe original article to which this Erratum refers was published in Journal of Mass Spectrometry 2005; 40: 36–42. Copyright © 2005 John Wiley & Sons, Ltd.
Low‐wavenumber dynamics of L‐alanine
Authors: Vik Aasmund F. , Yuzyuk Yuri I. , Barthes Mariette , Sauvajol Jean‐Louis 
Published: April 2005

AbstractL‐Alanine is one of the simplest amino acids, the building block for many polypeptides and proteins. A previous Raman scattering study showed an anomalous temperature dependence of the intensity of the two lowest Raman modes, attributed to dynamic localization of vibrational energy. The present Raman data, collected in the b(cc)b scattering geometry, were aimed at understanding the dynamics of the low‐wavenumber modes in connection with the reported anomalies in other physical properties. Our study shows that the energy and intensity of the observed external modes show unusual behaviour in the temperature range ∼150–250 K. The anomalous temperature dependence of the peak of the NH3+ torsional mode is confirmed. Its wavenumber has a singularity around ∼220 K and its full width at half‐maximum does not increase linearly with temperature. The CH3 torsion and CO2− rock undergo similar discontinuities below ∼250 K. The intensity of the two lowest wavenumbers librons at 42 and 48 cm−1 shows an anomalous temperature dependence and vary in an opposite way from that reported for the c(bb)a scattering geometry. The nature of the subtle symmetry breaking occuring below ∼250 K is discussed. Copyright © 2005 John Wiley & Sons, Ltd.
A Novel Process for Ultrasound‐Induced Radical Polymerization in CO2‐Expanded Fluids
Authors: Kemmere Maartje F. , Kuijpers Martijn W. A. , Prickaerts Ramona M. H. , Keurentjes Jos T. F. 
Published: April 2005

AbstractSummary: A strong viscosity increase upon polymerization hinders cavitation and subsequent radical formation during an ultrasound‐induced bulk polymerization. In this work, ultrasound‐induced radical polymerizations of methyl methacrylate (MMA) have been performed in CO2‐expanded MMA in order to reduce the viscosity of the reaction mixture. For this purpose, the phase behavior of CO2/MMA systems has been determined. With temperature oscillation calorimetry, the influence of CO2 on the viscosity and on the reaction kinetics of ultrasound‐induced polymerizations of MMA has been studied. In contrast to polymerizations in bulk, this technique shows that a low viscosity is maintained during polymerization reactions in CO2‐expanded MMA. As a consequence, a constant or even increasing polymerization rate is observed when pressurized CO2 is applied. Moreover, the ultrasound‐induced polymer scission in CO2‐expanded MMA is demonstrated, which appears to be a highly controlled process. Finally, a preliminary sustainable process design is presented for the production of 10 kg/h pure PMMA (specialty product) in CO2‐expanded MMA by ultrasound‐induced initiation.Process flow diagram of the ultrasound‐induced polymerization of MMA in CO2‐expanded MMA.magnified imageProcess flow diagram of the ultrasound‐induced polymerization of MMA in CO2‐expanded MMA.
Modeling of the Emulsion Terpolymerization of Styrene, α‐Methylstyrene and Methyl Methacrylate
Authors: Hoppe Sandrine , Schrauwen Cornélius , Fonteix Christian , Pla Fernand 
Published: April 2005

AbstractSummary: This work deals with modeling the terpolymerization of styrene, α‐methylstyrene and methyl methacrylate in the presence of an inhibitor. The model used is a “tendency model” based on the kinetics of the complex elementary chemical reactions both in the aqueous phase and in the particles. It considers the reversible propagation of α‐methylstyrene and the main physical phenomena occurring during the process, i.e., (i) partitioning of monomers, surfactant and inhibitor between the aqueous phase, polymer particles, monomer droplets and micelles; (ii) homogeneous and micellar nucleation; (iii) radical absorption and desorption; (iv) gel and glass effects. The main kinetic parameters of the model are estimated on the basis of batch experimental data in order to be able to describe the complete picture of this complex process. The model can be used to predict (with good precision) the global monomer conversion, number and weight‐average molecular weight, the average diameter and number of polymer particles and the glass transition temperature, and consequently to study the effects of AMS on conversion and terpolymer and latex characteristics.Comparison of experimental and simulated results of the weight‐average molecular weight versus conversion for the emulsion terpolymerization of styrene, alpha methylstyrene and methyl methacrylate at 60 °C.magnified imageComparison of experimental and simulated results of the weight‐average molecular weight versus conversion for the emulsion terpolymerization of styrene, alpha methylstyrene and methyl methacrylate at 60 °C.
Comparison of Olefin Polymerization Processes with Metallocene Catalysts
Authors: Kaminsky Walter , Müller Fabian , Sperber Oliver 
Published: April 2005

AbstractSummary: Solution and gas phase processes of the polymerization of ethene are compared using new types of pentalenyl bridged ansa‐metallocenes such as [Me3Pen(Flu)]ZrCl2. As of the bridge, the catalyst system is remarkable thermostable up to 105 °C and a deactivation of the metallocene on the silica support can be suppressed. Compared to the non‐supported catalyst in a solution process, the application of the heterogenized system in a gas phase process leads to a decrease in activities while molar masses of the polyethenes are similar. Due to a higher degree of short chain branches of 20–30 per 1 000 carbon atoms instead of 10–17, the melting temperatures are 10 °C lower than those for polymers obtained in the solution process.Basic structure of the here used pentalenyl bridged ansa‐metallocenes.magnified imageBasic structure of the here used pentalenyl bridged ansa‐metallocenes.