bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safe implementation of a minimally invasive hepatopancreatobiliary program, a narrative review and institutional experience
Authors: Labadie Kevin P. , Melstrom Laleh G. , Lewis Aaron G. 
Published: October 2023

AbstractLaparoscopic and robotic‐assisted approaches to hepatopancreatobiliary (HPB) operations have expanded worldwide. As surgeons and medical centers contemplate initiating and expanding minimally invasive surgical (MIS) programs for complex HPB surgical operations, there are many factors to consider. This review highlights the key components of developing an MIS HPB program and shares our recent institutional experience with the adoption and expansion of an MIS approach to pancreaticoduodenectomy.
The effect of timing between preoperative embolization and surgery: A retrospective analysis of hypervascular bone metastases
Authors: Acuña Alexander J. , Vijayakumar Gayathri , Buac Neil P. , Colman Matthew W. , Gitelis Steven , Blank Alan T. 
Published: October 2023

AbstractBackground and ObjectivesThe optimal timing between preoperative embolization of hypervascular metastatic bone lesions and surgery has yet to be established. Our analysis sought to evaluate embolization timing impacts blood loss, transfusion risk, and operative time in patients with hypervascular primary tumors.MethodsWe identified patients with renal cell (RCC) or thyroid carcinoma undergoing surgery between 1992 and 2023. Patients were segregated into the following cohorts: (1) no embolization preoperatively, (2) surgery <24 h of embolization, and (3) surgery >24 h after embolization. Multivariate logistic regression analyses were performed to assess the effect of embolization timing while controlling for confounding variables.ResultsNo differences were seen in all evaluated outcomes between immediate and delayed embolization cohorts. No differences in estimated blood loss were seen between the immediate (OR: 0.685, 95% CI: 0.159–2.949; p = 0.611) and delayed (OR: 0.568, 95% CI: 0.093–3.462; p = 0.539) surgery cohorts compared with patients without embolization. Surgery >24 h after embolization was not associated with a higher risk of prolonged operative time (OR: 13.499, 95% CI: 0.832–219.146; p = 0.067).ConclusionsThese findings suggest that surgery may be safely delayed beyond 24 h from embolization without a higher risk of bleeding. In appropriately selected cohorts, embolization may not be needed preoperatively.
Cross ownership and environmental corporate social responsibility with environmental cooperation
Authors: Cho Sumi , Lee Sang‐Ho 
Published: October 2023

AbstractWhen the cross owners of firms commit environmental corporate social responsibility (ECSR) as a commitment device to soften competition, environmental cooperation with their managers increases ECSR commitment levels. While lower degree of cross ownership between the firms reduces more emissions by increasing environmental R&D (ER&D) and improves welfare, higher degree of cross ownership causes both owners and managers to decrease ECSR and ER&D, which distorts environment and welfare, and these results can be expanded under environmental cooperation. In a coordination game, coordination failures can increase welfare when degrees of cross ownership are high and product markets are more competitive.
Quality assurance for mixed electron–photon beam radiation therapy using treatment log files and MapCHECK
Authors: Tai Yee Man , Heng Veng Jean , Renaud Marc‐André , Serban Monica , Seuntjens Jan 
Published: October 2023

AbstractBackgroundMixed photon–electron beam radiotherapy (MBRT) is a technique that combines the use of both photons and electrons in one single treatment plan to exploit their advantageous and complimentary characteristics. Compared to other photon treatment modalities, it has been shown that the MBRT technique contributes to better target coverage and organ‐at‐risk (OAR) sparing. However, the use of combined photons and electrons in one delivery makes the technique more complex and a well‐established quality assurance (QA) protocol for MBRT is essential.PurposeTo investigate the feasibility of using MapCHECK and log file‐dose reconstruction for MBRT plan verification and to recommend a patient‐specific quality assurance (PSQA) protocol for MBRT.MethodsMBRT plans were robustly optimized for five soft‐tissue sarcoma (STS) patients. Each plan comprised step‐and‐shoot deliveries of a six MV photon beam and a combination of five electron beam energies at an SAD of 100 cm. The plans were delivered to the MapCHECK device with collapsed gantry angle and the 2D dose distributions at the detector depth were measured. To simulate the expected dose distribution delivered to the MapCHECK, a MapCHECK computational phantom was modeled in EGSnrc based on vendor‐supplied blueprint information. The dose to the detectors in the model was scored using the DOSXYZnrc user code. The agreement between the measured and the simulated dose distribution was evaluated using 2D gamma analysis with a gamma criterion of 3%/2 mm and a low dose threshold of 10%. One of the plans was selected and delivered with a rotating gantry angle for trajectory log file collection. To evaluate the potential interlinac and intralinac differences, the plan was delivered repeatedly on three linacs. From the collected log files, delivery parameters were retrieved to recalculate the 3D dose distributions in the patient's anatomy with DOSXYZnrc. The recalculated mean dose to the clinical target volume (CTV) and OARs from all deliveries were computed and compared with the planned dose in terms of percentage difference. To validate the accuracy of log file‐based QA, the log file‐recalculated dose was also compared with film measurement.ResultsThe agreement of the total dose distribution between the MapCHECK measurement and simulation showed gamma passing rates of above 97% for all five MBRT plans. In the log file‐dose recalculation, the difference between the recalculated and the planned dose to the CTV and OARs was below 1% for all deliveries. No significant inter‐ or intralinac differences were observed. The log file‐dose had a gamma passing rate of 98.6% compared to film measurement.ConclusionBoth the MapCHECK measurements and log file‐dose recalculations showed excellent agreement with the expected dose distribution. This study demonstrates the potential of using MapCHECK and log files as MBRT QA tools.
Seasonal, spatial, and water level predictors of angler catch and effort within Texas black bass reservoir fisheries
Authors: Smith David R. , Schlechte J. Warren , Myers Randall A. , Dance Michael A. , Norman Jacob D. , Nisbet Mitchell T. 
Published: October 2023

Abstract

Objective
We sought to identify seasonal, spatial, and water level predictors of black bass angler catch rates and effort densities (i.e., angler-hours/ha) within Texas reservoirs.

Methods
We tested for predictors of effort density and catch rate while building generalized additive models with responses derived from a long-term creel data set and explanatory variables derived from the season of the creel survey, geoposition of the reservoir, and water level data obtained from the Texas Water Development Board.

Result
Season significantly affected models, with strong positive effects on catch rates during the spring and fall and strong positive effects on effort densities during the spring. Spatially, the strongest positive effects were observed for catch rates in the southern and eastern portions of the state and for effort densities in the northern and western portions of the state. Quarterly (i.e., 3 months) fluctuations in water level were identified as environmental drivers of catch rates and effort density during the springtime. Percent full (i.e., surface area relative to full pool) was also identified as a significant predictor, with increasing effort densities and catch rates at higher levels of percent full.

Conclusion
Our study provides a comparative baseline for future evaluations of black bass fisheries in Texas and a depiction of key factors influencing black bass angler catch rates and effort densities using a modeling approach that may be applied within a variety of fisheries research applications.
Determinants of perceived innovation in non‐governmental organizations in Nepal
Authors: KC Dipendra 
Published: October 2023

AbstractThis study examines how NGO board effectiveness and characteristics influence perceptions of innovation in Nepalese NGOs. Surveys of 225 board members found board effectiveness in resource acquisition and monitoring strongly predicted higher innovation perceptions, aligning with theories on the primacy of oversight. However, strategic involvement, diversity, tenure, and organizational characteristics showed insignificant or negative relationships. The strong positive link between resource oversight and innovation highlights the universal importance of this governance role. However, strategic involvement's insignificance suggests it may play a different role in non‐Western contexts based on cultural perspectives. Longer tenure's negative association indicates longevity can stifle innovation, so turnover may better encourage adaptability. Size only weakly predicted innovation, implying other factors like effectiveness are more impactful. While cross‐sectional, the developing country context provides useful insights on optimizing resource acquisition and monitoring to enable innovation. The findings indicate oversight effectiveness and active governance matter more than structural characteristics for NGO innovation.
Brain‐derived neurotrophic factor knock‐out mice develop non‐alcoholic steatohepatitis
Authors: Ichimura‐Shimizu Mayuko , Kojima Masami , Suzuki Shingo , Miyata Misaki , Osaki Yui , Matsui Konomi , Mizui Toshiyuki , Tsuneyama Koichi 
Published: October 2023

AbstractWhile brain‐derived neurotrophic factor (BDNF), which is a growth factor associated with cognitive improvement and the alleviation of depression symptoms, is known to regulate food intake and body weight, the role of BDNF in peripheral disease is not fully understood. Here, we show that reduced BDNF expression is associated with weight gain and the chronic liver disease non‐alcoholic steatohepatitis (NASH). At 10 months of age, BDNF‐heterozygous (BDNF+/−) mice developed symptoms of NASH: centrilobular/perivenular steatosis, lobular inflammation with infiltration of neutrophils, ballooning hepatocytes, and fibrosis of the liver. Obesity and higher serum levels of glucose and insulin – major pathologic features in human NASH – were dramatic. Dying adipocytes were surrounded by macrophages in visceral fat, suggesting that chronic inflammation occurs in peripheral organs. RNA sequencing (RNA‐seq) studies of the liver revealed that the most significantly enriched Gene Ontology term involved fatty acid metabolic processes and the modulation of neutrophil aggregation, pathologies that well characterise NASH. Gene expression analysis by RNA‐seq also support the notion thatBDNF+/−mice are under oxidative stress, as indicated by alterations in the expression of the cytochrome P450 family and a reduction in glutathione S‐transferase p, an antioxidant enzyme. Histopathologic phenotypes of NASH were also observed in a knock‐in mouse (BDNF+/pro), in which the precursor BDNF is inefficiently converted into the mature form of BDNF. Lastly, as BDNF reduction causes overeating and subsequent obesity, a food restriction study was conducted inBDNF+/promice. Pair‐fedBDNF+/promice developed hepatocellular damage and showed infiltration of inflammatory cells, including neutrophils in the liver, despite having body weights and blood parameters that were comparable to those of controls. This is the first report demonstrating that reduced BDNF expression plays a role in the pathogenic mechanism of NASH, which is a hepatic manifestation of metabolic syndrome. © 2023 The Pathological Society of Great Britain and Ireland.
Screening and identification of potential hypoglycemic and hypolipidemic compounds from aqueous extract of Scutellaria baicalensis Georgi root combing affinity ultrafiltration with multiple drug targets and in silico analysis
Authors: Xu Yongbing , Li Yawen , Chen Guilin , Fan Minxia , Hu Guangwan , Guo Mingquan 
Published: October 2023

AbstractIntroductionScutellaria baicalensis Georgi, a traditional Chinese medicine, is widely applied to treat various diseases among people, especially in East Asia. However, the specific active compounds in S. baicalensis aqueous extracts (SBAEs) responsible for the hypoglycemic and hypolipidemic properties as well as their potential mechanisms of action remain unclear.ObjectivesThis work aimed to explore the potential hypoglycemic and hypolipidemic compounds from SBAE and their potential mechanisms of action.MethodologyThe in vitro inhibitory tests against lipase and α‐glucosidase, and the effects of SBAE on glucose consumption and total triglyceride content in HepG2 cells were first performed to evaluate the hypoglycemic and hypolipidemic effects. Then, affinity ultrafiltration liquid chromatography–mass spectrometry (LC–MS) screening strategy with five drug targets, including α‐glucosidase, α‐amylase, protein tyrosine phosphatase 1B (PTP1B), lipase and 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) was developed to screen out the potential active constituents from SBAE, and some representative active compounds were further validated.ResultsSBAE displayed noteworthy hypoglycemic and hypolipidemic properties, and 4, 10, 4, 8, and 8 potential bioactive components against α‐amylase, α‐glucosidase, PTP1B, HMGCR, and lipase were initially screened out, respectively. The interaction network was thus constructed between the potential bioactive compounds screened out and their corresponding drug targets. Among them, baicalein, wogonin, and wogonoside were revealed to possess remarkable hypoglycemic and hypolipidemic effects.ConclusionThe potential hypolipidemic and hypoglycemic bioactive compounds in SBAE and their mode of action were initially explored through ligand–target interactions by combining affinity ultrafiltration LC–MS strategy with five drug targets.
Misophonia, self‐harm and suicidal ideation
Authors: Simner Julia , Rinaldi Louisa J. 
Published: October 2023

AbstractAimMisophonia is a sound sensitivity disorder characterized by an unusually strong aversion to a specific class of sounds—often human bodily sounds (e.g., chewing). These sounds can cause intense negative emotions which can cause profound difficulties in everyday life. The condition is linked with higher rates of anxiety and depression, and here we ask whether it co‐occurs with elevated self‐harm and suicidal thinking.MethodsWe measured self‐harm and misophonia in the general population by examining a birth cohort sample from the Avon Longitudinal Study of Parents and Children (ALSPAC). We screened them for misophonia as adults, then analyzed their earlier data on well‐being, self‐harm, and suicidal thinking.ResultsAdults with misophonia had significantly higher rates of self‐harm and suicidal ideation, as well as poorer well‐being in a number of different measures at ages 16–17 and 23–24 years. Female misophonics were particularly at risk, from as early as their teenage years, though males, too, show elevated self‐harm at 24 years compared to nonmisophonic peers.ConclusionOur data provide evidence of elevated risks of self‐harm associated with misophonia and suggest the need for greater recognition and treatment pathways.
Ayahuasca: A review of historical, pharmacological, and therapeutic aspects
Authors: Ruffell Simon G. D. , Crosland‐Wood Max , Palmer Rob , Netzband Nige , Tsang WaiFung , Weiss Brandon , Gandy Sam , Cowley‐Court Tessa , Halman Andreas , McHerron Diana , Jong Angelina , Kennedy Tom , White Eleanor , Perkins Daniel , Terhune Devin B. , Sarris Jerome 
Published: October 2023

AbstractAyahuasca is a psychedelic plant brew originating from the Amazon rainforest. It is formed from two basic components, the Banisteriopsis caapi vine and a plant containing the potent psychedelic dimethyltryptamine (DMT), usually Psychotria viridis. Here we review the history of ayahuasca and describe recent work on its pharmacology, phenomenological responses, and clinical applications. There has been a significant increase in interest in ayahuasca since the turn of the millennium. Anecdotal evidence varies significantly, ranging from evangelical accounts to horror stories involving physical and psychological harm. The effects of the brew on personality and mental health outcomes are discussed in this review. Furthermore, phenomenological analyses of the ayahuasca experience are explored. Ayahuasca is a promising psychedelic agent that warrants greater empirical attention regarding its basic neurochemical mechanisms of action and potential therapeutic application.
The impact of diabetes technology advances on quality of life: addressing the barriers to uptake
Authors: Kilvert Anne , Fox Charles 
Published: October 2023

AbstractOne hundred years after insulin was first used to treat diabetes, technology is advancing rapidly, with insulin pumps and continuous glucose monitoring devices established in clinical care. Hybrid closed loop systems have been successfully piloted in the UK and the National Institute for Health and Care Excellence is developing a guideline for access for people with type 1 diabetes.Initial studies of diabetes technology focused on glycaemic benefits, but many now include measures of quality of life/person reported outcome measures and diabetes‐specific and technology‐specific questionnaires have been validated. Focus groups and semi‐structured interviews can add insights to the personal experience.The quality of life evidence for technology is positive overall, but for some people the burdens of technology outweigh the benefits and create barriers to uptake. Health care professionals have a pivotal role in exploring individual barriers and priorities, managing expectations and providing education and support to help people achieve quality of life benefits as well as enhanced glycaemic control. They should take care to ensure equality of access for all by avoiding personal bias. Developers of the technology should involve stakeholders to ensure their needs are met. Copyright © 2023 John Wiley & Sons.
Revealing the influence of tether length on the intramolecular [3 + 2] cycloaddition reactions of nitrones from the molecular electron density theory perspective
Authors: Mondal Asmita , Domingo Luis R. , Acharjee Nivedita 
Published: October 2023

AbstractThe influence of ethylene substitution and the tether length between the two reacting counterparts on the selectivity and reactivity of the intramolecular [3 + 2] cycloaddition (IM32CA) reactions of cyclic nitrones leading to tricyclic isoxazolidines have been studied within the Molecular Electron Density theory at the MPWB1K/6‐311G(d,p) computational level. These zw‐type IM32CA reactions follow one‐step mechanism, and the activation barrier decreases with the introduction of electron withdrawing (EW) substituent at the alkene moiety in both the intramolecular and intermolecular versions. The IM32CA reactions involving unsubstituted alkene have non‐polar character with minimal electron density flux classified as null electron density flux type, while that involving the EW nitro substituted ethylene is more facile with a strong electron density flux from the nitrone to the ethylene moiety, classified as forward electron density flux type. The increase in the polar character of the IM32CA reaction decreases the activation Gibbs free energies associated with these intramolecular processes, while the highly polar IM32CA reactions are disfavored with respect to the intermolecular ones. Interestingly, the preferred regioselectivity observed in low polar IM32CA reactions having three methylene units between the nitrone and ethylene frameworks is reversed to that in nitrones separated with four methylene units, in conformity with the experimental outcome. Finally, electron localization function and quantum theory of atoms‐in‐molecules studies reveal that, in general, these IM32CA reactions involve early transition state structures in which the formation of new C‐C and C‐O single bonds have not yet started.
Molecular mechanism of sex pheromone perception in male Mythimna loreyi revealed by in vitro system
Authors: Zhang Yun‐Ying , Bai Teng‐Fei , Guo Jin‐Meng , Wei Zhi‐Qiang , Liu Si‐Ruo , He Yu , Ye Jing‐Jing , Yan Qi , Zhang Jin , Dong Shuang‐Lin 
Published: October 2023

AbstractBACKGROUNDMythimna loreyi is an important agricultural pest with a sensitive sex pheromone communication system. To clarify the pheromone binding proteins (PBPs) and pheromone receptors (PRs) involved in sex pheromone perception is important for both understanding the molecular olfactory mechanism and developing a new pest control strategy in M. loreyi.RESULTSFirst, the electroantennogram (EAG) assay showed that male M. loreyi displayed the highest response to the major sex pheromone component Z9‐14:Ac, and higher responses to two minor components, Z7‐12:Ac and Z11‐16:Ac. Second, the fluorescence competition binding assay showed that PBP1 bound all three pheromones and other tested compounds with high or moderate affinity, while PBP2 and PBP3 each bound only one pheromone component and few other compounds. Third, functional study using the Xenopus oocyte system demonstrated that, of the six candidate PRs, PR2 was weakly sensitive to the major pheromone Z9‐14:Ac, but was strongly sensitive to pheromone analog Z9‐14:OH; PR3 was strongly and specifically sensitive to a minor component Z7‐12:Ac; PR4 and OR33 were both weakly sensitive to another minor component, Z11‐16:Ac. Finally, phylogenetic relationship and ligand profiles of PRs were compared among six species from two closely related genera Mythimna and Spodoptera, suggesting functional shifts of M. loreyi PRs toward Spodoptera PRs.CONCLUSIONFunctional differentiations were revealed among three PBPs and six PRs in sex pheromone perception, laying an important basis for understanding the molecular mechanism of sex pheromone perception and for developing new control strategies in M. loreyi. © 2023 Society of Chemical Industry.
Pulmonary arterial hypertension drugs can partially restore altered angiogenic capacities in bmpr2‐silenced human lung microvascular endothelial cells
Authors: Tielemans Birger , Wagenaar Allard , Belge Catharina , Delcroix Marion , Quarck Rozenn 
Published: October 2023

AbstractMutations in the bone morphogenetic protein receptor type 2 (bmpr2) gene and signaling pathway impairment are observed in heritable and idiopathic pulmonary arterial hypertension (PAH). In PAH, endothelial dysfunction is currently handled by drugs targeting the endothelin‐1 (ET‐1), nitric oxide (NO), and prostacyclin (PGI2) pathways. The role of angiogenesis in the disease process and the effect of PAH therapies on dysregulated angiogenesis remain inconclusive. We aim to investigate in vitro whether (i) bmpr2 silencing can impair angiogenic capacity of human lung microvascular endothelial cells (HLMVECs) and (ii) PAH therapies can restore them. The effects of macitentan (ET‐1), tadalafil (NO), and selexipag (PGI2), on BMPRII pathway activation, endothelial barrier function, and angiogenesis were investigated in bmpr2‐silenced HLMVECs. Stable bmpr2 silencing resulted in impaired migration and tube formation in vitro capacity. Inhibition of ET‐1 pathway was able to partially restore tube formation in bmpr2‐silenced HLMVECs, whereas none of the therapies was able to restore endothelial barrier function, no deleterious effects were observed. Our findings highlight the potential role of BMPRII signaling pathway in driving pulmonary endothelial cell angiogenesis. In addition, PAH drugs display limited effects on endothelial function when BMPRII is impaired, suggesting that innovative therapeutic strategies targeting BMPRII signaling are needed to better rescue endothelial dysfunction in PAH.