bluuebunny/crossref_metadata_2025_split huggingface dataset:
How physicochemical and nutritional traits of potatoes may vary under field conditions over long periods
Authors: Ierna Anita , Mauromicale Giovanni 
Published: January 2024

AbstractBACKGROUNDPotato is the most important non‐grain crop worldwide, whose quality characteristics are always affected by temporal and spatial variability. Knowledge of the performance consistency of quality characteristics over long periods could prove very important to identify which quality traits are less variable over time, and therefore provide greater guarantees of stability. In this research, variations in physicochemical and nutritional traits of tubers over five consecutive growing seasons of two potato genotypes (Arizona and Vogue) were monitored in two locations.RESULTSAlthough qualitative performances of genotypes fluctuated across the seasons in both locations, two physicochemical traits (pH and dry matter content) and starch content showed less variability throughout the five seasons compared to total soluble solids and most of the nutritional traits (namely reducing sugars, citric acid, vitamin C, total phenolics and antioxidant capacity), which were considerably influenced by weather conditions.CONCLUSIONThe results suggest that pH, dry matter content and starch content traits could be used advantageously in studies of temporal stability in potatoes. This approach could prove useful in providing scientific support for the setup of potato protected geographical identifications. © 2024 Society of Chemical Industry.
Prevalent elements of consumer wellbeing in wearable technology use: An interdisciplinary systematic review and future research agenda
Authors: Mwangi Virginia Nyambura , Millard Rachael , Histon Wendy 
Published: January 2024

AbstractThe impact of wearable technology (wearables) on user wellbeing requires closer examination given the growth in adoption across multiple domains including workplaces, leisure, and healthcare. This paper consolidates research on consumer wellbeing and wearables through an interdisciplinary systematic review of 23 empirical journal articles from psychology, information technology and business domains. Our analysis highlights the principal conceptualizations of wellbeing and offers insights into theories, methods, and key variables in these studies. The findings reveal an overemphasis on adoption and usage of wearables in the literature; a narrow definition of wellbeing; and a limited range of theoretical and methodological perspectives. We propose that future research should be holistic, drawing on mainstream wellbeing theories and examining micro, meso, and macro level conceptualizations of wellbeing. Employing diverse methodologies such as longitudinal, time sampling, cross‐sectional, qualitative, and quantitative approaches, and randomized control trials. We develop a framework outlining avenues for future research to extend current understanding in this research domain.
Design of planar metal stripline filter and diplexer with frequency‐dependent couplings
Authors: Song Jiaxing , Rong Chuicai , Zhu Ruilong , Cao Dan , Xue Kai , Zhang Wen , Zhang Yiping , Liao Yubo 
Published: January 2024

AbstractIn this letter, frequency‐dependent coupling (FDC) is introduced into the design of metal stripline filters and diplexers for the first time. FDC is a popular research method to introduce the finite‐position transmission zeros in the synthesis and design of filters in recent years. Finite transmission zeros are critical for filters to enhance the rejection ratios. To verify the realizability and effectiveness of FDC, a filter centered at 3.52 GHz and a diplexer operating at 2.55 and 2.65 GHz have been designed and fabricated. The planar filter and diplexer are compact in structure with multiple transmission zeros, whose resonators and cavity are integrated and formed, the cavity and cover plate are soldered together. We designed, assembled and tested the filter and diplexer, the synthesis results, the simulation results, and the tested results are well matched with each other. Compared with the dielectric waveguide filter, the planar stripline filter has better insertion loss, better harmonic suppression, and higher reliability, which is expected to be widely used in 5G base station filters.
NMR characterization of uniformly 13C‐ and/or 15N‐labeled, unsulfated chondroitins with high molecular weights
Authors: Ichikawa Megumi , Otsuka Yuya , Minamisawa Toshikazu , Manabe Noriyoshi , Yamaguchi Yoshiki 
Published: January 2024

AbstractSolution nuclear magnetic resonance (NMR) analysis of polysaccharides can provide valuable information not only on their primary structures but also on their conformation, dynamics, and interactions under physiological conditions. One of the main problems is that non‐anomeric 1H signals typically overlap, and this often hinders detailed NMR analysis. Isotope enrichment, such as with 13C and 15N, will add a new dimension to the NMR spectra of polysaccharides, and spectral analysis can be performed with enhanced sensitivity using isolated peaks. For this purpose, here we have prepared uniformly 13C‐ and/or 15N‐labeled chondroitin polysaccharides –4)‐β‐D‐glucuronopyranosyl‐(1–3)‐2‐acetamido‐2‐deoxy‐β‐D‐galactopyranosyl‐(1– with molecular weights in the range from 310 to 460 k by bacterial fermentation. The enrichment ratios for 13C and 15N were 98.9 and 99.8%, respectively, based on the mass spectrometric analysis of the constituent chondroitin disaccharides. 1H and 13C NMR signals were assigned mainly based on HSQC and 13C‐detection experiments including INADEQUATE, HETCOR, and HETCOR‐TOCSY. The carbonyl carbon signal of the N‐acetyl‐β‐D‐galactosamine residue was unambiguously distinguished from the C6 carbon of the β‐D‐glucuronic acid residue by the observation of 13C peak splitting due to 1JCN coupling in 13C‐ and 15N‐labeled chondroitin. The T2* and T1 were measured and indicate that both rigid and mobile sites are present in the long sequence of chondroitin. The conformation, dynamics, and interactions of chondroitin and its derivatives will be further analyzed based on the results obtained in this study.
Provider perspectives and recommendations on standardized sexual function screening intervention in adolescent/young adult oncology patients
Authors: Demedis Jenna , Reedy Julia , Chow Eric J. , Dorsey Holliman Brooke , Peterson Pamela N. , Studts Christina R. 
Published: January 2024

AbstractBackgroundSexual function (SF) concerns are common among adolescent and young adult (AYA) cancer survivors, are underrecognized and undertreated. This study sought AYA oncology provider input on the implementation of an SF screening tool to address this unmet need.ProcedureSemi‐structured interviews were completed with oncology providers (n = 25) who care for AYAs at a single institution. Interviews sought to understand barriers to addressing SF, elicit perspectives on use of an established screening tool, and obtain recommendations for SF screening intervention development and implementation. Interviews were developed using the Consolidated Framework for Implementation Research (CFIR); thematic analysis‐guided interpretation.ResultsAYA oncology providers were in favor of using an SF screening tool, but confirmed previously identified barriers and implementation considerations within multiple CFIR domains, including concerns about privacy, patient comfort, provider buy‐in, provider knowledge, resource needs, and workflow/capacity constraints. They identified numerous strategies to address barriers through screening intervention design and implementation approaches. For example, provider buy‐in could be optimized through education, availability of clinical resources, creation of a dedicated sexual healthcare team, provider engagement in intervention development, and leadership involvement.ConclusionsDevelopment and implementation of an effective SF screening intervention is necessary to improve diagnosis and treatment of sexual dysfunction, with the ultimate goal of improving sexual health‐related quality of life in AYA cancer survivors. AYA oncology providers identified numerous intervention and implementation design strategies for the development and implementation of an SF screening intervention, which must be integrated with patient recommendations.
Tackling critical cases of the difference operator stability occurring in applications described by 1D distributed parameters
Authors: Rasvan Vladimir 
Published: January 2024

AbstractThe article starts from the challenge of the critical cases in difference operator stability for neutral functional differential equations (NFDE). Such cases occur in the NFDE associated to hyperbolic partial differential equations (PDE) dynamics in mechanical and hydraulic engineering. For some of such applications it resulted that the aforementioned critical (nonasymptotic) stability is connected to the character and level of the energy losses. It is shown that suitable choice of the losses to be taken into account can remove the critical stability properties and give the difference operator the asymptotic stability thus ensuring asymptotic stability for the system's dynamics and also other asymptotic properties.
Sr‐induced Fermi Engineering of β‐FeOOH for Multifunctional Catalysis
Authors: Ahmad Waqar , Hou Yunpeng , Ahmad Nisar , Wang Kun , Zou Chenghao , Wan Zhengwei , Aftab Sumaira , Zhou Shaodong , Pan Zhao , Gao Huai‐Ling , Liang Chengdu , Yan Wenjun , Ling Min , Lu Zhihui 
Published: January 2024

AbstractDesigning a multifunctional electrocatalyst to produce H2 from water, urea, urine, and wastewater, is highly desirable yet challenging because it demands precise Fermi‐engineering to realize stronger π‐donation from O 2p to electron(e−)‐deficient metal (t2g) d‐orbitals. Here a Sr‐induced phase transformed β‐FeOOH/α‐Ni(OH)2 catalyst anchored on Ni‐foam (designated as pt‐NFS) is introduced, where Sr produces plenteous Fe4+ (Fe3+ → Fe4+) to modulate Fermi level and e−‐transfer from e–‐rich Ni3+(t2g)‐orbitals to e–‐deficient Fe4+(t2g)‐orbitals, via strong π‐donation from the π‐symmetry lone‐pair of O bridge. pt‐NFS utilizes Fe‐sites near the Sr‐atom to break the H─O─H bonds and weakens the adsorption of *O while strengthening that of *OOH, toward hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), respectively. Invaluably, Fe‐sites of pt‐NFS activate H2‐production from urea oxidation reaction (UOR) through a one‐stage pathway which, unlike conventional two‐stage pathways with two NH3‐molecules, involves only one NH3‐molecule. Owing to more suitable kinetic energetics, pt‐NFS requires 133 mV (negative potential shift), 193 mV, ≈1.352 V, and ≈1.375 V versus RHE for HER, OER, UOR, and human urine oxidation, respectively, to reach the benchmark 10 mA cm−2 and also demonstrates remarkable durability of over 25 h. This work opens a new corridor to design multifunctional electrocatalysts with precise Fermi engineering through d‐band modulation.
Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1
Authors: Jooss Natalie J. , Diender Marije G. , Fernández Delia I. , Huang Jingnan , Heubel-Moenen Floor C. J. , van der Veer Arian , Kuijpers Marijke J. E. , Poulter Natalie S. , Henskens Yvonne M. C. , te Loo Maroeska , Heemskerk Johan W. M. 
Published: January 2024

AbstractThe platelet receptors, glycoprotein VI (GPVI) and integrin α2β1 jointly control collagen-dependent thrombus formation via protein tyrosine kinases. It is unresolved to which extent the ITIM (immunoreceptor tyrosine-based inhibitory motif) receptor PECAM1 and its downstream acting protein tyrosine phosphatase PTPN11 interfere in this process. Here, we hypothesized that integrin α2β1 has a co-regulatory role in the PECAM1- and PTPN11-dependent restraint of thrombus formation. We investigated platelet activation under flow on collagens with a different GPVI dependency and using integrin α2β1 blockage. Blood was obtained from healthy subjects and from patients with Noonan syndrome with a gain-of-function mutation of PTPN11 and variable bleeding phenotype. On collagens with decreasing GPVI activity (types I, III, IV), the surface-dependent inhibition of PECAM1 did not alter thrombus parameters using control blood. Blockage of α2β1 generally reduced thrombus parameters, most effectively on collagen IV. Strikingly, simultaneous inhibition of PECAM1 and α2β1 led to a restoration of thrombus formation, indicating that the suppressing signaling effect of PECAM1 is masked by the platelet-adhesive receptor α2β1. Blood from 4 out of 6 Noonan patients showed subnormal thrombus formation on collagen IV. In these patients, effects of α2β1 blockage were counterbalanced by PECAM1 inhibition to a normal phenotype. In summary, we conclude that the suppression of GPVI-dependent thrombus formation by either PECAM1 or a gain-of-function of PTPN11 can be overruled by α2β1 engagement.
Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study
Authors: Gregg Edward W. , Chen Haiying , Bancks Michael P. , Manalac Raoul , Maruthur Nisa , Munshi Medha , Wing Rena ,   for the Look AHEAD Research Group
Published: January 2024

Abstract
Aims/hypothesis
We examined the association of attainment of diabetes remission in the context of a 12 year intensive lifestyle intervention with subsequent incidence of chronic kidney disease (CKD) and CVD.

Methods
The Look AHEAD study was a multi-centre RCT comparing the effect of a 12 year intensive lifestyle intervention with that of diabetes support and education on CVD and other long-term health conditions. We compared the incidence of CVD and CKD among 4402 and 4132 participants, respectively, based on achievement and duration of diabetes remission. Participants were 58% female, and had a mean age of 59 years, a duration of diabetes of 6 year and BMI of 35.8 kg/m2. We applied an epidemiological definition of remission: taking no diabetes medications and having HbA1c <48 mmol/mol (6.5%) at a single point in time. We defined high-risk or very high-risk CKD based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria, and CVD incidence as any occurrence of non-fatal acute myocardial infarction, stroke, admission for angina or CVD death.

Results
Participants with evidence of any remission during follow-up had a 33% lower rate of CKD (HR 0.67; 95% CI 0.52, 0.87) and a 40% lower rate of the composite CVD measure (HR 0.60; 95% CI 0.47, 0.79) in multivariate analyses adjusting for HbA1c, BP, lipid levels, CVD history, diabetes duration and intervention arm, compared with participants without remission. The magnitude of risk reduction was greatest for participants with evidence of longer-term remission.

Conclusions/interpretation
Participants with type 2 diabetes with evidence of remission had a substantially lower incidence of CKD and CVD, respectively, compared with participants who did not achieve remission. This association may be affected by post-baseline improvements in weight, fitness, HbA1c and LDL-cholesterol.

Trial registration
ClinicalTrials.gov NCT00017953

Data availability
https://repository.niddk.nih.gov/studies/look-ahead/

Graphical Abstract
The string topology coproduct on complex and quaternionic projective space
Authors: Stegemeyer Maximilian 
Published: January 2024

AbstractOn the free loop space of compact symmetric spaces Ziller introduced explicit cycles generating the homology of the free loop space. We use these explicit cycles to compute the string topology coproduct on complex and quaternionic projective space. The behavior of the Goresky-Hingston product for these spaces then follows directly.
Steerable DROP-IN radioguidance during minimal-invasive non-robotic cervical and endometrial sentinel lymph node surgery
Authors: van Oosterom Matthias N. , Diaz-Feijóo Berta , Santisteban Maria Isabel , Sánchez-Izquierdo Núria , Perissinotti Andrés , Glickman Ariel , Marina Tiermes , Torné Aureli , van Leeuwen Fijs W. B. , Vidal-Sicart Sergi 
Published: January 2024

Abstract
Purpose
The recently introduced tethered DROP-IN gamma probe has revolutionized the way robotic radioguided surgery is performed, fully exploiting the nature of steerable robotic instruments. Given this success, the current first-in-human study investigates if the DROP-IN can also provide benefit in combination with steerable non-robotic instruments during conventional laparoscopic surgery, showing equivalence or even benefit over a traditional rigid gamma probe.

Methods
The evaluation was performed in ten patients during laparoscopic cervical (n = 4) and endometrial (n = 6) cancer sentinel lymph node (SLN) procedures. Surgical guidance was provided using the hybrid, or bi-modal, SLN tracer ICG-99mTc-nanocolloid. SLN detection was compared between the traditional rigid laparoscopic gamma probe, the combination of a DROP-IN gamma probe and a steerable laparoscopic instrument (LaproFlex), and fluorescence imaging.

Results
The gynecologists experienced an enlarged freedom of movement when using the DROP-IN + LaproFlex combination compared to the rigid laparoscopic probe, making it possible to better isolate the SLN signal from background signals. This did not translate into a change in the SLN find rate yet. In both cervical and endometrial cancer combined, the rigid probe and DROP-IN + LaproFlex combination provided an equivalent detection rate of 96%, while fluorescence provided 85%.

Conclusion
We have successfully demonstrated the in-human use of steerable DROP-IN radioguidance during laparoscopic cervical and endometrial cancer SLN procedures, expanding the utility beyond robotic procedures. Indicating an improved surgical experience, these findings encourage further investigation and consideration on a path towards routine clinical practice and improved patient outcome.

Trial registration
HCB/2021/0777 and NCT04492995; https://clinicaltrials.gov/study/NCT04492995
Machine learning for differentiating between pancreatobiliary-type and intestinal-type periampullary carcinomas based on CT imaging and clinical findings
Authors: Chen Tao , Zhang Danbin , Chen Shaoqing , Lu Juan , Guo Qinger , Cai Shuyang , Yang Hong , Wang Ruixuan , Hu Ziyao , Chen Yang 
Published: January 2024

Abstract
Purpose
To develop a diagnostic model for distinguishing pancreatobiliary-type and intestinal-type periampullary adenocarcinomas using preoperative contrast-enhanced computed tomography (CT) findings combined with clinical characteristics.

Methods
This retrospective study included 140 patients with periampullary adenocarcinoma who underwent preoperative enhanced CT, including pancreaticobiliary (N = 100) and intestinal (N = 40) types. They were randomly assigned to the training or internal validation set in an 8:2 ratio. Additionally, an independent external cohort of 28 patients was enrolled. Various CT features of the periampullary region were evaluated and data from clinical and laboratory tests were collected. Five machine learning classifiers were developed to identify the histologic type of periampullary adenocarcinoma, including logistic regression, random forest, multi-layer perceptron, light gradient boosting, and eXtreme gradient boosting (XGBoost).

Results
All machine learning classifiers except multi-layer perceptron used achieved good performance in distinguishing pancreatobiliary-type and intestinal-type adenocarcinomas, with the area under the curve (AUC) ranging from 0.75 to 0.98. The AUC values of the XGBoost classifier in the training set, internal validation set and external validation set are 0.98, 0.89 and 0.84 respectively. The enhancement degree of tumor, the growth pattern of tumor, and carbohydrate antigen 19–9 were the most important factors in the model.

Conclusion
Machine learning models combining CT with clinical features can serve as a noninvasive tool to differentiate the histological subtypes of periampullary adenocarcinoma, in particular using the XGBoost classifier.
Protective effect of low‐intensity pulsed ultrasound on immune checkpoint inhibitor-related myocarditis via fine-tuning CD4+ T-cell differentiation
Authors: Fu Shuai , Guo Zihong , Xu Xiangli , Li Yifei , Choi Stephen , Zhao Peng , Shen Wenqian , Gao Fei , Wang Chao , Chen Shuang , Li You , Tian Jiawei , Sun Ping 
Published: January 2024

Abstract
Purpose
Immune checkpoint inhibitors (ICIs) have transformed traditional cancer treatments. Specifically, ICI-related myocarditis is an immune-related adverse event (irAE) with high mortality. ICIs activate CD4+ T-lymphocyte reprogramming, causing an imbalance between Th17 and Treg cell differentiation, ultimately leading to myocardial inflammatory damage. Low-intensity pulsed ultrasound (LIPUS) can limit inflammatory responses, with positive therapeutic effects across various cardiovascular inflammatory diseases; however, its role in the pathogenesis of ICI-related myocarditis and CD4+ T-cell dysfunction remains unclear. Accordingly, this study investigated whether LIPUS can alleviate ICI-related myocarditis inflammatory damage and, if so, aimed to elucidate the beneficial effects of LIPUS and its underlying molecular mechanisms.

Methods
An in vivo model of ICI-related myocarditis was obtained by intraperitonially injecting male A/J mice with an InVivoPlus anti-mouse PD-1 inhibitor. LIPUS treatment was performed via an ultrasound-guided application to the heart via the chest wall. The echocardiographic parameters were observed and cardiac function was assessed using an in vivo imaging system. The expression of core components of the HIPPO pathway was analyzed via western blotting.

Results
LIPUS treatment reduced cardiac immune responses and inflammatory cardiac injury. Further, LIPUS treatment alleviated the inflammatory response in mice with ICI-related myocarditis. Mechanistically, in the HIPPO pathway, the activation of Mst1–TAZ axis improved autoimmune inflammation by altering the interaction between the transcription factors FOXP3 and RORγt and regulating the differentiation of Treg and Th17 cells.

Conclusion
LIPUS therapy was shown to reduce ICI-related myocarditis inflammatory damage and improve cardiac function, representing an exciting finding for irAEs treatment.
Enhanced impedance, electrical conductivity, dielectric properties for colloidal starch-g-poly (methyl methacrylate) supported with semiconductor cadmium sulfide
Authors: Torğut Gülben , Gürler Nedim 
Published: January 2024

AbstractIn this study, starch-graft-poly (methyl methacrylate) (starch-g-PMMA) composites doped with different amounts (5, 10, and 15 wt%) of cadmium sulfide (CdS) particles were fabricated for electrical measurements using in-situ polymerization technique. The structural characterization of the samples was studied. The dielectric and conductivity properties of the composites were investigated using impedance analyzer depending on the frequency (100 Hz–20 kHz) at room temperature. Spectroscopy revealed that the dielectric constant (ε′), dielectric loss (ε′′), and real (Z) components of impedance are found to decrease with increasing frequency for both starch-g-PMMA and starch-g-PMMA (5, 10, and 15 wt%) composites. On the contrary, the AC conductivity (σac) of samples increased with increasing frequency. In addition, ε′ and ε′′ values of starch-g-PMMA were lower than composites that added CdS. When the CdS content increased from 0 to 15%, ε′ increased from 5.62 to 15.10 at 100 Hz. AC conductivity was improved after adding the CdS particles. The maximum conductivity value for starch-g-PMMA15%CdS is found to be 3.07 × 10–7 at 100 Hz. When the dielectric properties of composites are evaluated, it is concluded that it is an exciting material for electronic applications in technology.