bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and Theoretical Model of Single Vessel Minimally Invasive Micro-Laser Ablation: Inducing Microvascular Network Remodeling and Blood Flow Redistribution Without Compromising Host Tissue Function
Authors: Gruionu Gabriel , Baish James , McMahon Sean , Blauvelt David , Gruionu Lucian G. , Lenco Mara Onita , Vakoc Benjamin J. , Padera Timothy P. , Munn Lance L. 
Published: December 2023

Abstract
Overly dense microvascular networks are treated by selective reduction of vascular elements. Inappropriate manipulation of microvessels could result in loss of host tissue function or a worsening of the clinical problem. Here, experimental, and computational models were developed to induce blood flow changes via selective artery and vein laser ablation and study the compensatory collateral flow redistribution and vessel diameter remodeling. The microvasculature was imaged non-invasively by bright-field and multi-photon laser microscopy, and Optical Coherence Tomography pre-ablation and up to 30 days post-ablation. A theoretical model of network remodeling was developed to compute blood flow and intravascular pressure and identify vessels most susceptible to changes in flow direction. The skin microvascular remodeling patterns were consistent among the five specimens studied. Significant remodeling occurred at various time points, beginning as early as days 1-3 and continuing beyond day 20. The remodeling patterns included collateral development, venous and arterial reopening, and both outward and inward remodeling, with variations in the time frames for each mouse. In a representative specimen, immediately post-ablation, the average artery and vein diameters increased by 14% and 23%, respectively. At day 20 post-ablation, the maximum increases in arterial and venous diameters were 2.5x and 3.3x, respectively. By day 30, the average artery diameter remained 11% increased whereas the vein diameters returned to near pre-ablation values. Some arteries regenerated across the ablation sites via endothelial cell migration, while veins either reconnected or rerouted flow around the ablation site, likely depending on local pressure driving forces. In the intact network, the theoretical model predicts that the vessels that act as collaterals after flow disruption are those most sensitive to distant changes in pressure. The model results match the post-ablation microvascular remodeling patterns.
The MCM3-AKT/Twist Pathway: Unveiling Its Prognostic Significance in Hepatocellular Carcinoma Progression
Authors: Tang Wei-Guo , Hu Jin-Wu , Li Xian , Sun Qi-Man , Ma Xiao-Lu , Nie Yan-Yan , Xu Yang , Sun Jian , Chang Meng-Qi 
Published: December 2023

Abstract
Background
Hepatocellular carcinoma (HCC), a leading cause of cancer fatalities, challenges clinicians with high recurrence and metastasis rates, urging the need for novel prognostic markers and therapeutic avenues. Minichromosome maintenance complex component 3 (MCM3) has been implicated in various cancers but its role in HCC is not well-characterized.
Methods
We investigated MCM3 expression in HCC through cell line and patient sample analyses, functional assays to determine its effect on cellular behaviors, and signal pathway exploration.
Results
Elevated MCM3 expression was identified in both HCC cell lines and patient tissues, correlating with microvascular invasion, advanced cancer stage, and reduced survival. Functionally, MCM3 fueled HCC cellular proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro, and expedited tumor growth in vivo. Mechanistically, MCM3 was found to potentiate EMT by upregulating Twist via the AKT signaling pathway.
Conclusions
MCM3 emerges as an oncogenic influencer in HCC, driving disease progression through the AKT/Twist axis. Its expression patterns hold prognostic value, and targeting MCM3 may offer a novel therapeutic strategy for HCC.
Toward the modelling of Laminated Veneer Lumber Stiffness and the influence of the number of plies
Authors: Peignon A. , Serra J. , Cantarel A. , Eyma F. , Castanié B. 
Published: December 2023

Abstract

This research paper studies the influence that the number of plies has on the identification of the mechanical properties of poplar Laminated Veneer Lumber (LVL) from tensile tests, such as its stiffness. LVL poplar specimens were prepared with different ply configurations and subjected to uniaxial tensile tests. Longitudinal and tangential rigidity were characterised in this research paper. The results show that the ply configuration influences the mechanical properties. The influence of the glued faces, the presence of lathe checks, and the glue line are also studied as well as the compression ratio of veneer during the manufacturing of the LVL. All these results provide valuable information for the design and optimization of laminated wood structures. An analytical modelling strategy is proposed to account for the effect of ply numbers, ply orientations, the compression ratio of veneers and the glue used on the stiffness of poplar laminate both in longitudinal and transverse directions.
Hydrochemical and hydrodynamic study to explore the origin of water in a volcanic aquifer
Authors: Vaezihir Abdorreza , Mohammadzadeh Tahereh , Tabarmayeh Mehri 
Published: December 2023

Abstract

The current research aimed to determine the origin of ions and the type of flow system in groundwater flowing out through two types of atmospheric and hydrothermal springs by hydrochemical and hydrodynamic approaches in a volcanic aquifer. Findings revealed that the major ion types in atmospheric waters are calcic and magnesium bicarbonate, whereas hydrothermal springs predominantly indicated chloride–sodic composition, showing an evolving pattern resulting from hydrothermal and atmospheric waters mixing. Investigating the ionic ratios and the saturation index to determine the origin of ions suggests that the presence of ions in the waters can be attributed to the weathering of silicates and plagioclase-bearing minerals in the volcanic units, and in some cases, ionic exchange also plays a role. The recession curve analysis revealed a predominant conduit flow with α = 0.144 in the system feeding the representative hydrothermal spring. Two micro-regimes with α1 = 0 = 0.46 and α2 = 2.68 were detected on the hydrograph of the atmospheric representative spring, indicating the development of systems with two types of flow regimes. Estimating the Qmax/Qmin ratio for selected hydrothermal and atmospheric springs as 2.3 and 36.8, respectively, and calculating the electrical conductivity coefficient as 11% and 18% respectively, confirmed the recession curve analysis result.
Análise Espacial Integrada da Degradação da Terra no Submédio São Francisco, Brasil
Authors: Das Neves Alves Ana Catarina , Barros Jocilene Dantas , Arcoverde Gustavo Felipe Balué , Ometto Jean Pierre Henry Balbaud 
Published: December 2023

O estudo analisou a degradação da terra na bacia do Submédio São Francisco por meio de índices segundo o modelo FPEIR (Força-Pressão-Estado-Impacto-Resposta). Para seleção dos 17 indicadores foi feita revisão bibliográfica e análise de correlação, os indicadores foram gerados em grades de 5 x 5 km no SIG QGIS através de dados secundários e primários. Foi feito um tratamento para exclusão de outliers, seguido de normalização dos indicadores. Foram gerados índices para cada componente FPEIR por meio da mediana dos indicadores e elaborados mapas dos indicadores e índices. As áreas mais vulneráveis à degradação (maiores valores nos índices FPEI) localizam-se principalmente nas regiões noroeste, centro e sudeste da bacia. Em relação à resposta (maiores valores no índice R), destacam-se as áreas a oeste, noroeste e sudeste da bacia. Os indicadores que mais influenciaram os índices FPEI foram Índice de Desenvolvimento Humano Municipal, estabelecimentos com produtor ocupante, desmatamento, erodibilidade, índice de aridez e pastagens degradadas. E no caso do índice de Resposta, a orientação técnica e programas de crédito. As políticas públicas e iniciativas particulares de restauração da qualidade ambiental são fundamentais para reverter o processo de degradação, contribuindo para o manejo sustentável da Caatinga.
Stakeholders’ Perspectives, Needs, and Barriers to Self-Management for People With Physical Disabilities Experiencing Chronic Conditions: Focus Group Study
Authors: Evans Eric , Zengul Ayse , Knight Amy , Willig Amanda , Cherrington Andrea , Mehta Tapan , Thirumalai Mohanraj 
Published: December 2023

Background
While self-management programs have had significant improvements for individuals with chronic conditions, less is known about the impact of self-management programs for individuals with physical disabilities who experience chronic conditions, as no holistic self-management programs exist for this population. Similarly, there is limited knowledge of how other stakeholders, such as caregivers, health experts, and researchers, view self-management programs in the context of disability, chronic health conditions, and assistive technologies.

Objective
This study aimed to obtain insight into how stakeholders perceive self-management relating to physical disability, chronic conditions, and assistive technologies.

Methods
Nine focus groups were conducted by 2 trained facilitators using semistructured interview guides. Each guide contained questions relating to stakeholders’ experiences, challenges with self-management programs, and perceptions of assistive technologies. Focus groups were audio recorded and transcribed. Thematic analysis was conducted on the focus group data.

Results
A total of 47 individuals participated in the focus groups. By using a constructivist grounded approach and inductive data collection, three main themes emerged from the focus groups: (1) perspectives, (2) needs, and (3) barriers of stakeholders. Stakeholders emphasized the importance of physical activity, mental health, symptom management, medication management, participant centeredness, and chronic disease and disability education. Participants viewed technology as a beneficial aide to their daily self-management and expressed their desire to have peer-to-peer support in web-based self-management programs. Additional views of technology included the ability to access individualized, educational content and connect with other individuals who experience similar health conditions or struggle with caregiving duties.

Conclusions
The findings suggest that the development of any web-based self-management program should include mental health education and resources in addition to physical activity content and symptom management and be cost-effective. Beyond the inclusion of educational resources, stakeholders desired customization or patient centeredness in the program to meet the overall needs of individuals with physical disabilities and caregivers. The development of web-based self-management programs should be holistic in meeting the needs of all stakeholders.

Trial Registration
ClinicalTrials.gov NCT05481593; https://clinicaltrials.gov/study/NCT05481593
Relación entre habilidad de metaconocimiento emocional, valoración ante la vida y nivel de ansiedad de funcionarios de un colegio de la ciudad de Concepción
Authors: Arriagada Allaire Cristina 
Published: December 2023

A partir de la importancia dada en los últimos años al desarrollo emocional en educación, y a los indicadores de bienestar subjetivo de profesionales de la educación, se realiza una investigación que busca medir el nivel de habilidades de conocimiento emocional, valoración ante la vida y ansiedad, en funcionarios docentes y no docentes de una institución educacional para analizar la relación entre dichas variables. El método utilizado fue en base a un diseño descriptivo correlacional transeccional, participaron 80 funcionarios (55 mujeres y 25 hombres), cuya edad media fue de 39 años.
Los instrumentos usados fueron el TMMS-24 para medir metaconocimiento emocional, el test LOT-R para medir orientación ante la vida, y la escala ansiedad del DASS-21. Los resultados muestran indicadores medianamente altos de metaconocimiento emocional, orientación a la vida mayoritariamente optimista, y bajo nivel de ansiedad. Se observan correlaciones estadísticamente significativas entre subdimensiones, pero no en variables globales. Se concluye que los cuestionarios, al ser de autorreporte podrían haber sido objeto de deseabilidad social, pues los resultados en general no coinciden con lo señalado en los estudios teóricos. Se destaca la existencia de correlación positiva, significativa y moderada entre optimismo como orientación a la vida y reparación emocional.
Tratamiento biológico de aguamieles del café y su reúso para fertirriego en pasto King grass (Pennisetum Purpureum x Pennisetum Typhoide)
Authors: Trujillo Rodríguez Luisa Fernanda , Murillo Arango Walter 
Published: December 2023

Las aguamieles generadas en el proceso de beneficio húmedo del café se convierten en uno de los subproductos más contaminantes de fuentes hídricas y del suelo debido a su alta carga orgánica representada en nutrientes como lípidos, enzimas, proteínas, azúcares, entre otros. Objetivo: evaluarla eficiencia de los procesos biológicos encaminados a la reducción de la DQO y la DBO en un sistema artesanal para el tratamiento de aguamieles del café y su potencial uso al final del proceso. Materiales y métodos: se construyó un sistema artesanal para el tratamiento biológico de las aguamieles del café compuesto por dos biofiltros inoculados con microorganismos eficientes y una laguna verde que incluye el uso de plantas acuáticas como Azolla filiculoidesy Pistia stratiotes, la eficiencia del proceso se midió a través del análisis de las variables pH,sólidos suspendidos totales, turbidez, DBO yDQO. Resultados: se obtuvieron remociones de hasta el 93,4 % para la DBO y del 94,24 %para la DQO, cumpliendo de esta forma con los lineamientos del artículo 9 de la Resolución 631de 2015, en cuanto a vertimiento de aguamieles. Posteriormente, las aguamieles tratadas se utilizaron para fertirregar parcelas de pasto King grass de un año de siembra, y se comparó frente a parcelas sin tratamiento. Se observó alta producción de biomasa en las parcelas fertirregadas, la composición nutricional del pasto y esto sin afectar las características del suelo. Se analizaron muestras de suelos de las parcelas con y sin fertirriego, encontrándose incremento de nutrientes en las parcelas tratadas y como resultado anexo se obtuvo aumento en la producción de biomasa hasta en un 223 %. Conclusión: el sistema artesanal de tratamiento mostró altos porcentajes de remoción de carga orgánica de las aguamieles, habilitando su reúso para fertirriego de pasto King grass con altos rendimientos de biomasa.
Gobernanza del agua: un análisis sistemático de desafíos, temáticas y propuestas para una gestión hídrica sostenible
Authors: Gárate Ríos Jhonny , Pashanasi Amasifuen Beto , Palomino Alvarado Gabriela Del Pilar , Pereyra Gonzales Tony Venancio 
Published: December 2023

La gobernanza del agua es un medio para lograr eficiencia y eficacia en la gestión y presenta una tendencia creciente hacia la necesidad de una gestión sostenible, especialmente en el contexto de la escasez creciente de agua. El objetivo de este trabajo fue llevar a cabo una aproximación teórica que permitió identificar principios, atributos y valores clave mediante una revisión de producción científica disponible en Scopus, SciELO y Science Direct. Como resultado, destacan temas de centralización y fragmentación en planificación y capacidad de gestión del agua, acentuando como una característica que más sobresale, la relación directa entre gobernanza y gestión del agua. Se concluye que existen limitaciones en la capacidad técnica y profesional y fomento de participación de actores.
ALPHA-2A ADRENERGIC RECEPTOR (α2AR) ACTIVATION IN GENETIC ABSENCE EPILEPSY: AN ABSENCE STATUS MODEL?
Authors: Yavuz Melis , AKKOL SERDAR , Onat Filiz 
Published: December 2023

BACKGROUND AND PURPOSE: The updates in the definition of absence status
epilepticus raise questions about the pathophysiological aspects of
absence status. Here, we propose an animal model of absence status
epilepticus, induced by specific alpha 2a adrenergic receptor (α2AR)
activation. EXPERIMENTAL APPROACH: An α2AR agonist, dexmedetomidine was
injected intracerebroventricularly into the adult rats with genetic
absence epilepsy and the electroencephalography (EEG) from animals was
recorded. The total duration, number and mean duration of each
spike-and-wave discharges (SWDs) were evaluated. The blocks of absence
status events were classified as first and second set of absence
statuses. Ethosuximide was given as a pre-treatment to another group of
animals, later injected with 2.5 μg dexmedetomidine. Power spectral
characteristics and coherence analysis for the absence status events and
sleep were performed on the EEG. KEY RESULTS: The 2.5 µg dose of
dexmedetomidine increased the total SWD duration and induced continuous
SWDs up to 26 min. Following a first absence status event, sleep is
induced and it was followed by the second set of absence status events.
Ethosuximide pre-treatment blocked the occurrence of these events. Power
spectral density analyses revealed that dexmedetomidine
injection-induced absence seizures and the absence seizures following
sleep had lower spectral power than typical SWDs in the frequency bands.
CONCLUSIONS AND IMPLICATIONS: This study presents that activation of
α2AR may induce absence status epilepticus and this can be an animal
model to study the pathophysiological role of absence status. Our
results strengthen the significant role of α2AR in SWD generation or
termination.
**This article has been reviewed and published at Epilepsia open with
doi number:

https://doi.org/10.1002/epi4.12879
Classifying Internal Control Deficiencies: The Case of Magnum Hunter Resources Corporation
Authors: Bucaro Anthony C. , Keyser John D. 
Published: December 2023

ABSTRACT
Magnum Hunter Resources Corporation (MHRC) was an oil and gas company headquartered near Dallas, TX. Although the company grew rapidly through acquisitions, the accounting department did not keep pace with the company’s growing size and sophistication. Management identified this as an internal control deficiency (ICD) prior to issuing the 2011 financial statements but did not disclose it because management underestimated its severity. The company later disclosed multiple material weaknesses when it restated its financial statements. This case study is designed for use in the undergraduate or graduate audit classroom to examine the classification and disclosure requirements for ICDs. After completing this case study, students will be able to apply professional standards to classify ICDs; critique the decision-making process of management, consultants, and auditors tasked with evaluating ICDs; and consider the impact of material weakness disclosure on investors.
JEL Classifications: M41; M42.
An Interprofessional Quality Improvement Project to Reduce Community-Acquired Central Line-Associated Bloodstream Infections in the Pediatric Intestinal Failure Population
Authors: Neumeister Samantha , Gabel Megan E , Meyers Jeffrey M , Tesini Brenda , Gottfried Julie Albright , Fairchild Acadia , Schriefer Jan 
Published: December 2023

Highlights

Abstract

Aim:
Central line-associated bloodstream infections (CLABSIs) result in significant morbidity but are largely preventable. Methods to reduce hospital-acquired CLABSIs are well described, but few recommendations exist for how these practices might translate to patients with central lines in the ambulatory setting. This team sought to reduce the mean monthly community-acquired CLABSI rate by 25% from 11.7 to 8.8 per 1000 community line-days in children with intestinal failure who require home parenteral nutrition within 12 months.

Methods:
First, an interprofessional quality improvement team was formed. After baseline data collection, plan-do-study-act cycles began. Tests of change consisted of a central venous catheter (CVC) maintenance bundle. This bundle included a CVC care tote with additional supplies, improved educational materials, and ethanol lock prophylaxis. A control chart was used to display the monthly community-acquired CLABSI rate and observe for special cause variation.

Results:
At baseline, the average monthly community-acquired CLABSI rate was 11.7 per 1000 community catheter-days. The home CVC maintenance bundle was implemented, after which there were 5 consecutive months with no infections. After enhancements to the care bundle and tote, special cause variation was noted, and the average monthly community-acquired CLABSI rate declined by 66% to 4 per 1000 community catheter-days. Special cause variation was noted at 2 other time points without an identifiable cause.

Conclusion:
A lower community-acquired CLABSI rate has been sustained for 24 months and reflects approximately 12 fewer infections per year in this at-risk population.
Can I Join in? Understanding Children’s Participation in Play
Authors: Sand Anne-Lene , Jensen Jens-Ole , Skovbjerg Helle Marie , Hede Jørgensen Hanne 
Published: December 2023

Based on a design-based research project and ethnographic observations of children’s play in school and after-school activities, the paper analyses how children participate in play. Using participatory sense-making (De Jaegher & Di Paolo, 2007) the main contribution of this paper is to show diversity in sensory, playful participation in children’s play, and emphasise the importance of paying attention to the not spoken, sensory, embodied movements that children share when playing. The analysis illustrates that children participate in play through a sensory engagement, which is short, intense and not spoken, and by taking part in other children’s and adults’ participatory approaches.
The use of language material on the example of Russian proverbs in Mongolian textbooks of the Russian language for grades 7–9 in secondary schools in Mongolia
Authors: Леонтьев Эдуард Петрович , Давыдова Евгения Анатольевна , Николаев Александр Константинович 
Published: December 2023

Дается анализ использования русских пословиц в учебниках по русскому языку «Орос хэл» для 7–9-х классов общеобразовательной школы Монголии. Раскрывается содержательная сторона учебников, которая определяет взаимосвязь грамматического и языкового материала. Дана краткая характеристика учебников по структуре, использованным источникам. Сделан акцент на функциональное использование русских пословиц на начальном этапе обучения русскому языку как иностранному, осуществлен подбор примеров использования пословиц в соответствии с их тематической принадлежностью, видом задания и методическими рекомендациями. Определены несоответствия выбора пословиц как языкового материала для учебников русского языка на основе общепринятых критериев в методике преподавания русского языка как иностранного.
In this article, an analysis of the use of Russian proverbs in Russian language textbooks “Russian language” for 7-9 classes of general education schools in Mongolia is given. The content side of the textbooks is revealed, which determines the relationship between grammatical and linguistic material. A brief description of the textbooks is given in terms of structure and sources used. Determined all proverbs according to thematic group, corresponding to those tasks in the textbook and methodical guide for the teacher of the Russian language. Emphasis is placed on the functional use of Russian proverbs at the initial stage of teaching Russian as a foreign language, and a selection of examples of the use of proverbs is carried out in accordance with their thematic affiliation, type of task and methodological recommendations. The inconsistencies in the choice of proverbs as language material for Russian language textbooks are determined on the basis of generally accepted criteria in the methodology of teaching Russian as a foreign language. Some recommendations are given for working with proverbs when teaching Russian as a foreign language, in particular, for using them in different types of work orally (presentation, explanation, examples of synonymous Mongolian proverbs, translation into Mongolian).