bluuebunny/crossref_metadata_2025_split huggingface dataset:
LAS PRIMERAS ELECCIONES MUNICIPALES DEMOCRÁTICAS EN CÓRDOBA Y SU PROVINCIA A TRAVÉS DE LA PRENSA CORDOBESA / THE FIRST DEMOCRATIC AND MUNICIPAL ELECTIONS IN CORDOBA AND ITS PROVINCE BY OF THE LOCAL PRESS
Authors: Pérez López Asunción 
Published: October 2023

(ES)Resumen: La Transición española (1975‐1982) ha sido uno de los periodos más importantes de la Historia de nuestro país. La historiografía se ha dedicado a estudiar de forma exhaustiva todos los procedimientos que han contribuido a la llegada de la Democracia a España. Pero la celebración de las primeras elecciones municipales democráticas de 1979 es analizada esquemáticamente. El objetivo principal de este trabajo es abundar en la importancia que merece al hecho que hizo posible la transformación democrática de la Administración local, teniendo como referencia la ciudad de Córdoba. La elección libre y democrática de las élites del poder local es fundamental, para una comprensión completa y correcta de este período histórico.Palabras clave: Transición española, Democracia, Elecciones Municipales, Administración local, Poder local. (EN)Abstract: The Spanish Transition (1975‐1982) has been one of the most important periods in the History of our country. The science which studies the History has investigated thoroughly about all procedures that got the Democracy in Spain. These searchings analyze the first democratic and municipal elections in 1979 as a schene without bearing in mind a complete scientific or historical approach. The main goal of this project is to give importance to the fact that made the democratic change of the Local Administration possible, taking as reference Córdoba city. In this way, the freedom on the democratic election of a local government is something essential for a complete and right understanding of this historic period.Key words: Spanish Transition, Democracy, Municipal Elections, Local Administration, Local Government.
Structure and Properties of Multilayer Nanocomposite Coatings of Polyvinyl Alcohol with Aluminum Oxide Nanoparticles
Authors: Sapsaliou D. V. , Petrovskaya A. S. , Radyukevich D. L. , Tolstaya T. N. , Melnikova G. B. , Chizhik S. A. 
Published: October 2023

The nanocomposite polymer – inorganic materials formation, the study of their morphology and mechanical properties at the nanolevel is acute in the development of new materials for various functional purposes, including medical ones. As a result of the research the technique for producing singleand multilayer films of polyvinyl alcohol and composite polymer coatings with aluminum oxide nanoparticles by the spin coating method has been developed. It is shown that the optimal mass content of aluminum oxide nanoparticles in suspension for the formation of uniform composite coatings is 0.625 %. Based on experimental data on the structuralmorphological and mechanical properties of the formed coatings obtained by atomic force microscopy, it has been found that an increase in the number of layers of composite coatings leads to an increase in the number of conglomerates which, in turn, increases the surface roughness of the films. The modulus of elasticity of single-layer films of polyvinyl alcohol is (509.5 ± 10 %) MPa. In the case of composite coatings with aluminum oxide nanoparticles, changes in the elastic modulus have been established for multilayer coatings: an increase to 559.0 MPa (5 layers) and a decrease to 415.2 MPa (10 layers). The modulus of elasticity of the investigated single-layer coatings is significantly reduced in the range of 20−40 ºС. The smallest values after exposure to temperatures have been determined for films with nanoparticles (236.2 ± 10 %) MPa. Nanocomposites demonstrate an increase in the contact angle with an increase in the number of layers of composite coatings up to 20. A subsequent increase in the thickness of the coatings (the number of layers) leads to an increase in the hydrophilicity of the nanocomposites. The developed compositions of nanocomposite films are promising as sorption coatings.
On Possibility of Application of COMSOL Multiphysics Software for Topological Optimization of Osteosynthesis Plates
Authors: Stepanenko D. A. , Mudinov I. , Akhremchyk V. A. , Akhremchyk V. A. 
Published: October 2023

Тhe paper describes a technique of topological optimization of osteosynthesis plates used for internal fixation of bone fractures. The proposed technique is based on the application of the density method and the commercially available COMSOL Multiphysics software intended for finite element modeling. A comparative analysis of the characteristics (axial stiffness, volume and maximum von Mises stress) is presented for initial design of the plate and two optimized variants of the design. It has been established that the optimized variants provide a reduction in the plate volume by 49–54 %. In this case, the axial stiffness decreases by 43–53 %, which is a positive effect in terms of minimizing the effect of stress shielding. The optimized variants of the design possess close values of axial stiffness and maximum von Mises stress, however, in one of them, deflection of the axial segments occurs, resulting in an increase in the total strain energy, which is used as an objective function during optimization. In the variant 2 of the design, the deflection of the longitudinal segments of the plate is eliminated due to the presence of a transverse bridge between them, and the total strain energy takes on a lower value. The variant of the design without a bridge should be additionally studied, since shear stresses resulting from the contact interaction of the longitudinal segments of the plate with the bone can have a positive effect on regeneration of the bone tissue.
The use of acupuncture among chronic disease patients attending primary health facilities: a cross-sectional study in Korea
Authors: Lee Su Yeon , Choi Soo Jeung , Im Hyea Bin , Choi Dain , Han Dongwoon 
Published: October 2023

Abstract
Background
Given the crucial role of integrating acupuncture treatment into primary care for managing chronic diseases, this study endeavors to identify the utilization of acupuncture among chronic disease patients seeking primary care services in Korea. Additionally, it aims to evaluate their knowledge level and perceptions related to acupuncture use.
Methods
A descriptive cross-sectional study was conducted among chronic disease patients attending a primary care clinic in Korea. A self-reported questionnaire comprising 37 items was employed to evaluate the utilization of acupuncture treatment. These items covered socio-demographic information, respondents' health status, levels of acupuncture knowledge, and patterns of acupuncture use. Using the SPSS Statistics 26.0 Network Version program, descriptive statistics, a chi-square test, and a logistic regression analysis were performed to identify factors associated with acupuncture treatment.
Results
Out of 370 respondents, 44.3% reported utilizing acupuncture treatment. The most popular reason for the utilization of acupuncture was to enhance the effectiveness of the current treatment. The patients with musculoskeletal disease had the highest utilization rate of 53.2%. The main source of information for acupuncture use was family and friends. The average score for the level of knowledge on acupuncture treatment among the respondents was 65.4%, and the knowledge level of the acupuncture group was high. Potential predictors of acupuncture use included musculoskeletal disease, and intention to recommend acupuncture.
Conclusion
This study highlights the widespread acceptance of acupuncture use among patients with chronic diseases in primary healthcare context. Integration of acupuncture into primary care emerges as a viable avenue for effective chronic disease management, and fostering a comprehensive and holistic approach to healthcare.
Creeping Flow of Carreau Fluid Through a Porous Slit
Authors: malik rabia , Sadaf Hina , asif tahreem 
Published: October 2023

Abstract

We will investigate the creeping flow of a Carreau incompressible fluid through a slit with uniformly porous walls. Non-dimensionalization is used to represent the controlling two-dimensional flow equations and non-homogeneous boundary conditions. The resulting equations are solved using a recursive method. Equations are developed for the stream function, velocity components, volumetric flow rate, pressure distribution, shear and normal stresses on the slit wall as well as in general, fractional absorption, and leakage flux. Moreover, maximum velocity component points are noted. This topic offers a mathematical foundation for comprehending the physical phenomenon of fluid flows via slit walls, which occurs in a variety of issues such as biological systems, gaseous diffusion, and filtration.
Prenatal opioid use as a predictor of postpartum suicide attempt among reproductive-age women enrolled in Oregon Medicaid
Authors: Yoon Jangho , Masoumirad Mandana , Bui Linh N. , Richard Patrick , Harvey S. Marie 
Published: October 2023

Abstract
Background
The rates of suicide and opioid use disorder (OUD) among pregnant and postpartum women continue to increase. This research characterized OUD and suicide attempt among Medicaid-enrolled perinatal women and examined prenatal OUD as a marker for postpartum suicide attempt.
Methods
Data from Oregon birth certificates, Medicaid eligibility and claims files, and hospital discharge records were linked and analyzed. The sample included Oregon Medicaid women aged 15–44 who became pregnant and gave live births between January 2008 and January 2016 (N = 61,481). Key measures included indicators of suicide attempt (by any means and opioid poisoning), OUD, major depressive disorders (MDD), and substance use disorders (SUD), in pregnancy and one-year postpartum. Probit regression was used to estimate an overall relationship between prenatal OUD and postpartum suicide attempt. A simultaneous equations model was used to explore a link between prenatal OUD and postpartum suicide attempt via postpartum OUD.
Results
Thirty-three women attempted suicide in pregnancy (53.7 attempts per 100,000). Postpartum suicide attempts were more frequent with 58 attempts (94.3 attempts per 100,000) and a majority (n = 46) involved OUD. Prenatal OUD was associated with a greater risk of suicide attempt by opioid poisoning, as well as with postpartum OUD, SUD, and MDD. Prenatal OUD was associated with an increased risk of attempting postpartum suicide by opioid poisoning through postpartum OUD.
Conclusions
The risk of suicide attempt by opioid poisoning is elevated for Medicaid-enrolled reproductive-age women during pregnancy and postpartum. Prenatal OUD may increase the risk of attempting postpartum suicides.
Enhanced lipid biosynthesis in OSCC cancer associated fibroblasts contributes to tumor progression: role of IL8/AKT/p-ACLY axis
Authors: Liu Pan , Wang Yue , Li Xiang , Liu Zhenan , Sun Yunqing , Liu Hanzhe , Shao Zhe , Jiang Erhui , Zhou Xiaocheng , Shang Zhengjun 
Published: October 2023

Abstract
Background
ATP citrate lygase (ACLY), the key enzyme regulating lipid synthesis, has been proven to play a critical role in tumor initiation and development. However, the roles and relevant mechanisms of ACLY in cancer associated fibroblasts (CAFs) have rarely been studied, particularly in CAFs of oral squamous cell carcinoma (OSCC). Plus, the molecular mechanism by which tumor cells regulate ACLY in fibroblasts is unclear.
Methods
IHC staining, PCR and Western blot were employed to detect ACLY expression pattern in OSCC tissues and OSCC primary CAFs. The biological roles and relevant mechanisms of ACLY in OSCC CAFs were investigated by in vitro and in vivo experiments.
Results
The phosphorylated ACLY (p-ACLY) was highly expressed in OSCC CAFs and CAFs underwent enhanced lipid synthesis, including elevated intracellular level of acetyl-CoA and accumulation of lipid droplets. Conversely, inhibition of p-ACLY blocked this biological process. Moreover, blocking lipid synthesis in CAFs or inhibiting fatty acid uptake by OSCC cells reduced the promotive effects of CAFs on OSCC cell proliferation, invasion and migration. These results suggested that CAFs served as one of lipid sources for OSCC cells during tumor progression. Mechanistically, AKT signaling activation was involved in the elevations of p-ACLY level and lipid synthesis in CAFs. IL8 was an exocrine cytokine of OSCC cells that could activate AKT and then phosphorylate ACLY in fibroblasts.
Conclusions
P-ACLY positively regulated lipid synthesis of OSCC CAFs, making CAFs one of the lipid sources required for tumor progression. IL8 was an exocrine cytokine of OSCC cells that could upregulate p-ACLY level and lipid synthesis in fibroblasts via AKT signaling activation. Therefore, the IL8/AKT/p-ACLY axis could be considered as a potential therapeutic target for OSCC treatment.
A meta-analysis of the effects of opioid-free anesthesia on postoperative analgesia and recovery after various types of surgery
Authors: Sha Kaiyuan , Yang Bin , Ou Cehua , Zhang Yue 
Published: October 2023

Abstract
Background
Opioids are widely used to manage stress responses during surgery and postoperative pain. However, opioids have both short-term and long-term side effects, The feasibility of opioid-free anesthesia is controversial. This meta-analysis aims to collect the current evidence on opioid-free anesthesia and analyze whether opioid-free anesthesia is feasible.
Method
We searched Cochrane-Library, Pubmed database and EMBASE. Included were randomized controlled trials published between January 2000 and March 2023 in which at least one opioid-free study group was not using opioids before surgery, during induction of anesthesia, and before recovery from anesthesia. The Primary outcome was postoperative pain score (2h and 24h) , the Secondary outcomes were extubation time, discharge time from the post-anesthesia care unit, incidence of nausea and vomiting, opioid consumption, and Postoperative recovery quality score between strict opioid-free and opioid-based general anesthesia.
Result
37 RCTs were eventually included, involving a total of 2723 patients. Meta-analysis showed that in a comprehensive analysis of all included studies, opioid-free anesthesia (OFA) had no clinically significant effects on postoperative extubation time, PACU discharge time, postoperative pain score at 2h, and postoperative recovery quality score. However, it is clinically significant that the incidence of nausea and vomiting after opioid-free anesthesia (OFA) (MD=0.32,955CI: [0.22,0.45], I2= 43%,P<0.00001), pain score at 24h after surgery (MD=-0.72, 95%CI: [-0.90, -0.53], I2= 60%,P=0.007,and opioid consumption after surgery (MD=-2.07, 95%CI: [-2.65,-1.50], I2= 60%,P<0.00001) are reduced. Through subgroup analysis of opioid-free anesthesia for different types of surgery, we found that opioid-free anesthesia has different effects on patients with different types of surgery.
Double bad luck: pulmonary embolism and vaginal bleeding - a case report
Authors: Shiba Sarah , Keer Jan Van 
Published: October 2023

Abstract
Background: Pulmonary embolism is a common and potentially fatal condition. Exogenous estrogens in contraceptives are associated with an increased risk of venous thrombo-embolism. However, discontinuation of a combined oral contraceptive can lead to severe withdrawal bleeding in an anticoagulated patient.
Case presentation: We report a case of a 47-year-old female who presented to the emergency room with a two-day history of worsening shortness of breath and chest pain. Her chronic medication included a combined oral contraceptive pill. Transthoracic echocardiogram showed pulmonary hypertension and right ventricular dilatation. Computerized tomography scan revealed bilateral pulmonary embolism. She received thrombolysis with alteplase and was started on rivaroxaban. Five days after discharge, however, she was readmitted with severe vaginal bleeding.
Discussion and conclusion: We describe a case of submassive pulmonary embolism, treated with thrombolysis and anticoagulation, who developed severe vaginal bleeding after stopping the contraceptive pill. While discontinuation of combined contraceptive is important in reducing the risk of recurrent thrombosis, we argue that discontinuation can potentially be postponed until after the initial phase of high-intensity anticoagulation and until a safe alternative has been established.
Predefined time and accuracy adaptive fault-tolerant control for nonlinear systems with multiple faults
Authors: Su Yakun , Jiang Yaling , Tong Miao , Wang Huanqing 
Published: October 2023

Abstract
This work mainly studies the issue of predefined time and accuracy adaptive fault-tolerant control for nonlinear systems with multiple faults. The faults in the control system include actuator faults and external system faults. The unknown function parts for nonlinear systems are approximated by fuzzy logic system (FLS). And then, according to the backstepping technique and the predefined time stability theory, an adaptive fuzzy control algorithm is presented, which can make sure that all closed-loop system signals remain bounded within a predefined time and the tracking error converges to a predefined accuracy within the predefined time. Ultimately, the effectiveness of the presented control algorithm is proved through a simulation example.
A novel mutation in SORD gene associated with Distal Hereditary Motor Neuropathies
Authors: Yuan Xiaoqin , Zhang Shanshan , Shang Huifang , Tang Yufeng 
Published: October 2023

Abstract
Background
Distal hereditary motor neuropathy (dHMN) is a heterogeneous group of hereditary diseases caused by the gradual degeneration of the lower motor neuron. More than 30 genes associated with dHMN have been reported, while 70–80% of those with the condition are still unable to receive a genetic diagnosis.
Methods
A 26-year-old man experiencing gradual weakness in his lower limbs was referred to our hospital, and data on clinical features, laboratory tests, and electrophysiological tests were collected. To identify the disease-causing mutation, we conducted whole exome sequencing (WES) and then validated it through Sanger sequencing for the proband and his parents. Silico analysis was performed to predict the pathogenesis of the identified mutations. A literature review of all reported mutations of the related gene for the disease was performed.
Results
The patient presented with dHMN phenotype harboring a novel homozygous variant c.361G > C (p.Ala121Pro) in SORD, inherited from his parents, respectively. A121 is a highly conserved site and A121P is predicted to disrupt its normal splicing. A total of 13 published articles including 101 patients reported 18 SORD variants. Almost all described cases have the homozygous deletion variant c.757delG (p.A253Qfs*27) or compound heterozygous state of a combination of c.757delG (p.A253Qfs*27) with another variant. The variant c.361G > C (p.Ala121Pro) detected in our patient was the second homozygous variant in SORD-associated hereditary neuropathy.
Conclusion
One novel homozygous variant c.361G > C (p.Ala121Pro) in SORD was identified in a Chinese patient with dHMN phenotype, which expands the mutation spectrum of SORD-associated hereditary neuropathy and underscores the significance of screening for SORD variants in patients with undiagnosed hereditary neuropathy patients.
Machine learning can reliably predict malignancy of breast lesions based on clinical and ultrasonographic features.
Authors: Buzatto Isabela Carlotti , Recife Sarah Abud , Miguel Licerio , Onari Nilton , Faim Ana Luiza Peloso , Bonini Ruth Morais , Silvestre Liliane , Carlotti Danilo Panzeri , Fröhlich Alek , Tiezzi Daniel Guimarães 
Published: October 2023

Abstract
Purpose
To establish a reliable machine learning model to predict malignancy in breast lesions identified by ultrasound and optimize the negative predictive value to minimize unnecessary biopsies.
Methods
We included clinical and ultrasonographic attributes from 1526 breast lesions classified as BI-RADS 3, 4a, 4b, 4c, 5 and 6 that underwent ultrasound guided breast biopsy in four institutions. We selected the most informative attributes to train nine machine learning models, ensemble models and models with tuned threshold to make inferences about the diagnosis of BI-RADS 4a and 4b lesions (validation dataset). We tested the performance of the final model with 403 new suspicious lesions.
Results
The most informative attributes were shape, margin, orientation and size of the lesions, the resistance index of the internal vessel, the age of the patient and the presence of a palpable lump. The highest mean NPV was achieved with KNN (97.9%). Making ensembles didn´t improve the performance. Tuning the threshold did improve the performance of the models and we chose the XGBoost with the tuned threshold as the final one. The tested performance of the final model was: NPV 98.1%, FN 1.9%, VPP 77.1%, FP 22.9%. Applying this final model, we would have missed 2 of the 231 malignant lesions of the test dataset (0.8%).
Conclusion
Machine learning can help physicians predict malignancy in suspicious breast lesions identified by the US. Our final model would be able to avoid 60.4% of the biopsies in benign lesions missing less than 1% of the cancer cases.
A new method for intuitionistic fuzzy multi-objective linear programming based on fuzzy reasoning GA
Authors: Esmaeili Mahin , Jafarpour Morteza , Shahsavari-Pour Nasser 
Published: October 2023

Abstract
‎An attempt is made to propose a new method for the intuitionistic fuzzy multi-objective linear programming (IFMOLP) problems by applying the intuitionistic fuzzy (IF) coefficients and IF inequality relations‎. ‎The IFMOLP problem is considered a rule-based system where optimizing the similarity of the truth table method is applied in intuitionistic fuzzy reasoning. A customized GA is proposed to solve this problem‎. Examples are presented to confirm the efficiency of this newly proposed method‎, vs. its counterparts in this context.
Associations between domains of sedentary behavior, well-being, and quality of life – A cross-sectional study
Authors: Teno Sabrina C , Silva Marlene N , Júdice Pedro B. 
Published: October 2023

Abstract
Background
The importance of reducing sedentary behavior (SB) in the prevention of mortality and chronic and mental diseases is scientifically well grounded, but SB can be accumulated in diverse domains of life, such as leisure-time SB, transport between home/work/school when sitting (transport-related SB), or in occupational settings such as working or studying (occupational SB), and the associations for each domain of SB with well-being measures and quality of life are still underexplored from a positive perspective.
Methods
Through a cross-sectional investigation, we collected data from 584 participants who completed a questionnaire throughout November 2021 and with Spearman correlation test, analysed the associations between SB in three different domains with psychological well-being, satisfaction with life, and quality of life.
Results
Our results indicated that after adjustment for physical activity, sex, body mass index, smoking history, chronic disease status, financial perception, quality, and duration of sleep, in younger adults (18 to 24 years old), leisure-time SB was negatively related to psychological well-being (rho = -0.254; p = 0.008), and in adults (25 to 64 years old), occupational SB was negatively related to satisfaction with life (rho = -0.255; p < .001) and the mental component of quality of life (rho = -0.174; p = 0.018).
Conclusions
Our findings highlight the idea that not all SB is built the same and that future strategies to reduce SB from people’s lives must target specific domains of SB according to the age group when aiming to improve well-being and quality of life.