bluuebunny/crossref_metadata_2025_split huggingface dataset:
Density functional studies of AnF6 (An=U, Np, and Pu) and UF6−nCln (n=1–6) using hybrid functionals: geometries and vibrational frequencies
Authors: Han Young‐Kyu 
Published: August 2002

AbstractWe have compared the performance of widely used hybrid functionals for calculating the bond lengths and harmonic vibrational frequencies of AnF6 (An=U, Np, and Pu) and UF6−nCln (n=1–6) molecules using “small‐core” relativistic effective core potentials and extended basis sets. The calculated spectroscopic constants compare favorably with experimental data for the bond lengths (average error ≤ 0.01 Å) and vibrational frequencies (average error ≤ 7 cm−1) of the AnF6 molecules. The experimental vibrational frequencies of the stretching modes were available for most of the UF6−nCln (n=1–6) molecules. The calculated vibrational frequencies are in good agreement with the experimental data to within 4.6 cm−1 and 7.6 cm−1 for selected Becke1 and Lee, Yang, Parr (B1LYP), and Becke3 and Perdew, Wang (B3PW91) functionals, respectively. We conclude that one can predict reliable geometries and vibrational frequencies for the unknown related systems using hybrid density functional calculations with the RECPs. The geometries and vibrational frequencies of the UF6−nCln (n=1–6) molecules that have not been determined experimentally are also presented and discussed. © 2001 John Wiley & Sons, Inc. J Comput Chem 22: 2010–2017, 2001
There exists no (15,5,4) RBIBD†*
Authors: Kaski Petteri , Östergård Patric R. J. 
Published: August 2002

AbstractAn (n, M, d)q code is a q‐ary code of length n, cardinality M, and minimum distance d. We show that there exists no (15,5,4) resolvable balanced incomplete block design (RBIBD) by showing that there exists no (equidistant) (14,15,10)3 code. This is accomplished by an exhaustive computer search using an orderly algorithm combined with a maximum clique algorithm. © 2001 John Wiley & Sons, Inc. J Combin Designs 9: 357–362, 2001
Plasma and urinary endothelin&hyphen;1 in focal segmental glomerulosclerosis
Authors: Chen Hung&hyphen;Chun , Guh Jinn&hyphen;Yuh , Chang Jer&hyphen;Ming , Tsai Jer&hyphen;Chia , Hwang Shang&hyphen;Jyi , Lai Yung&hyphen;Hsiung 
Published: August 2002

AbstractThe kidney is an important site of endothelin&hyphen;1 &lpar;ET&hyphen;1&rpar; production and is particularly susceptible to ET&hyphen;1 action. Infusion of ET&hyphen;1 in rats induces both functional and morphological alterations in the kidneys. Increased plasma level of ET&hyphen;1 has been reported in patients with chronic renal failure. However, there are still no reports on the plasma and urinary ET&hyphen;1 levels in patients with focal segmental glomerulosclerosis &lpar;FSGS&rpar;. In the present study, we have measured the plasma concentration and urinary excretion rate of ET&hyphen;1 in 15 patients with nephrotic syndrome due to FSGS, and observed the serial changes of plasma and urinary ET&hyphen;1 in nephrotic rats with FSGS, induced by repeated injection with puromycin aminonucleoside &lpar;PAN&rpar;. ET&hyphen;1 was measured with radioimmunoassay. The results showed that plasma ET&hyphen;1 concentration in FSGS patients was significantly higher than in normal controls &lpar;P &lt; 0.05&rpar;, and that urinary ET&hyphen;1 excretion rate was also significantly higher in FSGS patients than in normal controls &lpar;P &lt; 0.01&rpar;. In FSGS patients, the plasma and urinary ET&hyphen;1 was significantly correlated &lpar;P &lt; 0.05&rpar;, and the urinary ET&hyphen;1 excretion rate was significantly correlated with the amount of proteinuria &lpar;P &lt; 0.05&rpar; and the glomerular sclerosing score &lpar;P &lt; 0.01&rpar;. In the ten rats with PAN&hyphen;induced FSGS, serial examination showed a significant increase in plasma ET&hyphen;1 after 8 weeks of injections, while the urinary ET&hyphen;1 excretion rate showed a biphasic increase that showed a peak after 4 to 6 weeks. The same changes in plasma and urinary ET&hyphen;1 levels were not observed in control rats injected with normal saline at the same frequency. Our results suggest that ET&hyphen;1 may be involved in the pathogenesis of FSGS in both humans and rats. J. Clin. Lab. Anal. 15:59&ndash;63, 2001. &copy; 2001 Wiley&hyphen;Liss, Inc.
Introduction: Perspectives on therapy with gay, lesbian, and bisexual clients
Authors: Campos Peter E. , Goldfried Marvin R. 
Published: August 2002

AbstractThe approach that mental health professionals have taken in working with gay, lesbian, and bisexual (GLB) clients has changed dramatically over the past 25 years. Once viewed as being pathological in nature—either a sociopathic personality disorder or a sexual deviation—homosexuality is no long conceptualized as a “disorder” and instead is viewed within the broader context of human diversity. Even with such changes, many mental health professionals nonetheless retain subtle biases against working with gay, lesbian, and bisexual clients, and often lack the necessary information for working with them effectively. This issue of In Session provides a series of articles designed to help practicing therapists to become better aware of those clinical issues if they are to work with GLB individuals—which they are likely to do. © 2001 John Wiley & Sons, Inc. J Clin Psychol/In Session 57: 609–613, 2001.
Ethical beliefs of mental‐health professionals and undergraduates regarding therapist practices
Authors: Pomerantz Andrew M. , Grice James W. 
Published: August 2002

AbstractPsychotherapists should be aware of any discrepancies of opinion between themselves and those outside the mental‐health profession regarding the ethicality of therapist actions. In this study, the beliefs of mental‐health professionals and nonprofessionals (represented by undergraduate students) regarding the ethicality of therapist behaviors were compared. Factor analysis of 82 specific therapist behaviors yielded three factors: nonsexual dual relationships, assertive or discomforting therapist actions, and sexual dual relationships. A comparison of factor composite scores indicated that undergraduates, in relation to professionals, rated nonsexual dual relationships as more ethical and assertive or discomforting actions as less ethical. Although these effects may diminish with age, these results nonetheless suggest that mental‐health professionals may hold ethical beliefs that are inconsistent with those who seek their services. Implications of these findings are discussed. © 2001 John Wiley & Sons, Inc. J Clin Psychol 57: 737–748, 2001.
Discriminative validity of the MacAndrew Alcoholism Scale with Cluster B personality disorders
Authors: Smith Steven R. , Hilsenroth Mark J. 
Published: August 2002

AbstractThis study was designed to assess the ability of the Minnesota Multiphasic Personality Inventory (MMPI‐2) MacAndrew Alcoholism Scale (MAC‐R) to differentiate between outpatients with personality disorders with Substance‐Related Disorders (SRDs) and without SRDs. MMPI‐2 validity, clinical, and MAC‐R scale scores were compared in an SRD Cluster B group (comprised of Narcissistic, Antisocial, Borderline, and Histrionic; n = 15), a non‐SRD Cluster B group (n = 33), and a non‐SRD group with personality disorders from Clusters A and C (n = 18). Results revealed that the substance‐abusing Cluster B group scored significantly higher on the MAC‐R ( p < .0001) as well as the Psychopathic Deviate scale ( p < .01). Dimensional analyses illustrated that MAC‐R scores were related to the presence of an SRD diagnosis (rpb = .70, p < .0001) and diagnostic criteria for Antisocial Personality Disorder (r = .60, p < .0001). Stepwise regression revealed that (in order of magnitude) the presence of a substance‐abuse diagnosis followed by diagnostic criteria for Antisocial and Histrionic Personality Disorders were most related to MAC‐R scores (R = .78, R2 = .60). This indicates that the MAC‐R may be more related to the presence of an SRD than has been suggested, and when used in outpatient settings as MacAndrew (1965) intended, the MAC‐R may be useful as a screening device for assessing SRD among outpatients with Axis II psychopathology. © 2001 John Wiley & Sons, Inc. J Clin Psychol 57: 801–813, 2001.
Relations between personality and depressive symptoms: A multimeasure study of dependency, autonomy, and related constructs
Authors: Burke Ainsley , Haslam Nick 
Published: August 2002

AbstractSeventy‐four patients seeking treatment for major depression completed four measures of dependent and autonomous personality and two measures of depressive symptomatology. Relationships among the personality measures were investigated by principal‐components analysis, enabling systematic comparison of their composition. Relationships between personality components and symptom dimensions were examined to clarify specific associations that have been proposed but inconsistently obtained in previous research. Neither dependency nor autonomy were unitary constructs, and alternative measures had substantial differences in composition. Some support for symptom specificity was obtained. Dependency and autonomy have distinctive associations with depressive symptoms, but their correspondence to unitary personality dimensions and the equivalence of their alternative scales cannot be assumed. © 2001 John Wiley & Sons, Inc. J Clin Psychol 57: 953–961, 2001.
A motivational interviewing perspective on resistance in psychotherapy
Authors: Moyers Theresa B. , Rollnick Stephen 
Published: August 2002

AbstractThis article applies the motivational interviewing approach to resistance, which is conceptualized as the product of an interaction between the therapist and client rather than a static client characteristic. The underlying principles of motivational interviewing also are discussed, as are the overall therapeutic goals when using this approach. Sources of the resistance between the therapist and client are reviewed, as well as specific recommendations for responding. The motivational interviewing approach to resistance is applied to each of the three case vignettes. © 2002 John Wiley & Sons, Inc. J Clin Psychol/In Session 58: 185–193, 2002.
Resistance in psychotherapy: What conclusions are supported by research
Authors: Beutler Larry E. , Moleiro Carla , Talebi Hani 
Published: August 2002

AbstractTheoretical literature is contradictory in most areas, but virtually all theories agree on the existence of patient resistance and propose similar implications, meanings, and effects of its manifestation. However, theories differ widely in both the assumed causes of resistance and the methods of dealing with resistant patients. Common to various theoretical definitions is an assumption that resistance is both a dispositional trait and an in‐therapy state of oppositional, angry, irritable, and suspicious behaviors. Reactance is a special class of resistance that is manifest in oppositional and uncooperative behavior. Resistance bodes poorly for treatment effectiveness. Nondirective and paradoxical strategies have been found to be quite successful in overcoming resistant and reactant states, while matching low‐directive and self‐directed treatments with resistant patients circumvents the effects of resistance traits. © 2002 John Wiley & Sons, Inc. J Clin Psychol/In Session 58: 207–217, 2002.
Effects of TGF‐α gene knockout on epithelial cell kinetics and repair of methotrexate‐induced damage in mouse small intestine
Authors: Xian Cory J. , Cool Jo C. , Howarth Gordon S. , Read Leanna C. 
Published: August 2002

AbstractWhile previous studies have indicated that exogenous TGF‐α stimulates epithelial growth, maintenance, and repair of the gut, roles of endogenous TGF‐α are less well‐defined particularly in the small bowel. The current study examined effects of TGF‐α knockout on adult small intestinal epithelial cell proliferation, migration, apoptosis, and damage/repair response after methotrexate treatment. Compared to normal mice, TGF‐α gene knockout did not affect crypt cell production, mitosis position, migration, and apoptosis in non‐injured intestine. RT‐PCR gene expression analysis revealed presence of four out of six TGF‐α related EGF family ligands in the normal intestine, suggesting a possible functional redundancy of the EGF family in maintenance of the intestine. Although TGF‐α gene knockout did not significantly impair the overall mucosal repair in methotrexate‐induced acute damage in the small intestine, it resulted in a higher apoptotic response in the early hours following methotrexate challenge, and a delayed and reduced crypt cell proliferation during repair. Consistently, after methotrexate challenge, intestinal TGF‐α mRNA was found to be markedly upregulated in the early hours and during repair in the wild type, and there were similar profiles in the increased expression of all other ligands (except EGF) between the wild type and knockout intestines. Therefore, despite a possible functional redundancy among the EGF family ligands in the normal small intestine, TGF‐α may play a role in modulating the early apoptotic events and in enhancing the subsequent reparative proliferative response in the methotrexate‐damaged intestine. J. Cell. Physiol. 191: 105–115, 2002. © 2002 Wiley‐Liss, Inc.
Signaling of monocytic differentiation by a non‐hypercalcemic analog of vitamin D3, 1,25(OH)2‐5,6 trans‐16‐ene‐vitamin D3, involves nuclear vitamin D receptor (nVDR) and non‐nVDR–mediated pathways
Authors: Ji Yan , Wang Xuening , Donnelly Robert J. , Uskokovic Milan R. , Studzinski George P. 
Published: August 2002

AbstractExposure of leukemia cells to the physiologically active form of vitamin D3, 1,25‐dihydroxyvitamin D3(1,25D3) normalizes their phenotype to cells that resemble mature monocytes. One of the earliest detectable events in this process is an upregulation of the nuclear receptor for 1,25D3, the vitamin D receptor (nVDR). In contrast, the novel analog of 1,25D3, 1,25‐dihydroxy‐5,6 trans‐16‐ene‐vitamin D3(5,6‐16D3), which has recently been reported to have low calcium‐mobilizing activity in vivo, rapidly induced the expression of CD14, CD11b, and monocyte‐specific esterase (MSE), classical markers of the mature monocyte, but upregulated nVDR expression less than 1,25D3. This upregulation was shown to be the result of altered degradation of the nVDR protein, while the levels of nVDR mRNA were constant. Knock‐out of nVDR transcriptional activity by a decoy VDRE double‐stranded deoxyoligonucleotide, markedly abrogated 1,25D3‐induced differentiation, but incompletely inhibited 5,6‐16D3‐induced differentiation. These findings suggest that the unique ability of 5,6‐16D3to induce cell differentiation but not systemic hypercalcemia, may be due to the activation of pathways which initiate differentiation independently of nVDR. J. Cell. Physiol. 191: 198–207, 2002. © 2002 Wiley‐Liss, Inc.
The gene PC3TIS21/BTG2, prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?
Authors: Tirone Felice 
Published: August 2002

AbstractPC3TIS21/BTG2 is the founding member of a family of genes endowed with antiproliferative properties, namely BTG1, ANA/BTG3, PC3B, TOB, and TOB2. PC3 was originally isolated as a gene induced by nerve growth factor during neuronal differentiation of rat PC12 cells, or by TPA in NIH3T3 cells (named TIS21), and is a marker for neuronal birth in vivo. This and other findings suggested its implication in the process of neurogenesis as mediator of the growth arrest before differentiation. Remarkably, its human homolog, named BTG2, was shown to be p53‐inducible, in conditions of genotoxic damage. PC3TIS21/BTG2 impairs G1–S progression, either by a Rb‐dependent pathway through inhibition of cyclin D1 transcription, or in a Rb‐independent fashion by cyclin E downregulation. PC3TIS21/BTG2 might also control the G2 checkpoint. Furthermore, PC3TIS21/BTG2 interacts with carbon catabolite repressor protein‐associated factor 1 (CAF‐1), a molecule that associates to the yeast transcriptional complex CCR4 and might influence cell cycle, with the transcription factor Hoxb9, and with the protein‐arginine methyltransferase 1, that might control transcription through histone methylation. Current evidence suggests a physiological role of PC3TIS21/BTG2 in the control of cell cycle arrest following DNA damage and other types of cellular stress, or before differentiation of the neuron and other cell types. The molecular function of PC3TIS21/BTG2 is still unknown, but its ability to modulate cyclin D1 transcription, or to synergize with the transcription factor Hoxb9, suggests that it behaves as a transcriptional co‐regulator. © 2001 Wiley‐Liss, Inc.
Requirement of protein kinase Cα, extracellular matrix remodeling, and cell–matrix interaction for transforming growth factorβ‐regulated expression of E‐cadherin and catenins
Authors: Wang Hongmei , Chakrabarty Subhas 
Published: August 2002

AbstractA hallmark of transforming growth factorβ (TGFβ) action is the induction of the synthesis and secretion of extracellular‐matrix adhesion molecules and induction of the cell‐surface expression of integrin receptors for these molecules (termed extracellular‐matrix remodeling). The signal pathways leading to extracellular‐matrix remodeling and the significance of extracellular‐matrix remodeling in TGFβ function is not well‐understood. In the epithelium‐derived human colon cancer cell line Moser, TGFβ induces extracellular‐matrix remodeling in a protein kinase Cα‐dependent manner. In this study we showed that TGFβ was a potent inducer of the homotypic cell–cell adhesion molecule E‐cadherin and its undercoat‐associated proteins, the catenins and dramatically increased the amount of E‐cadherin/γ‐catenin complex formation. We found that the induction of E‐cadherin and α‐ and β‐catenin by TGFβ was also dependent on protein kinase Cα, whereas the induction of γ‐catenin was independent of protein kinase Cα but dependent on other protein kinase C isoforms. We also found that protein kinase Cα‐dependent induction of extracellular‐matrix remodeling and subsequent cell–matrix interaction requiring both fibronectin and laminin were a prerequisite for the induction of E‐cadherin (and α‐ and β‐catenin but not γ‐catenin) by TGFβ. We therefore concluded that two signal pathways exist in TGFβ‐regulated expression of E‐cadherin and the catenins. We also concluded that a functional significance of TGFβ‐induced extracellular matrix remodeling is the activation of signal transduction mechanisms through increased interaction between extracellular matrix fibronectin and laminin and their cell‐surface integrin receptors, which lead to the induction of E‐cadherin (and α‐ and β‐catenin). © 2001 Wiley‐Liss, Inc.
Pigment epithelium‐derived factor inhibits retinal and choroidal neovascularization
Authors: Mori Keisuke , Duh Elia , Gehlbach Peter , Ando Akira , Takahashi Kyoichi , Pearlman Joel , Mori Keiko , Yang Hoseong S. , Zack Donald J. , Ettyreddy Damodar , Brough Douglas E. , Wei Lisa L. , Campochiaro Peter A. 
Published: August 2002

AbstractIn this study, we investigated whether overexpression of pigment epithelium‐derived factor (PEDF) by gene transfer can inhibit neovascularization by testing its effect in three different models of ocular neovascularization. Intravitreous injection of an adenoviral vector encoding PEDF resulted in expression of PEDF mRNA in the eye measured by RT‐PCR and increased immunohistochemical staining for PEDF protein throughout the retina. In mice with laser‐induced rupture of Bruch's membrane, choroidal neovascularization was significantly reduced after intravitreous injection of PEDF vector compared to injection of null vector or no injection. Subretinal injection of the PEDF vector resulted in prominent staining for PEDF in retinal pigmented epithelial cells and strong inhibition of choroidal neovascularization. In two models of retinal neovascularization (transgenic mice with increased expression of vascular endothelial growth factor (VEGF) in photoreceptors and mice with oxygen‐induced ischemic retinopathy), intravitreous injection of null vector resulted in decreased neovascularization compared to no injection, but intravitreous injection of PEDF vector resulted in further inhibition of neovascularization that was statistically significant. These data suggest that sustained increased intraocular expression of PEDF by gene therapy might provide a promising approach for treatment of ocular neovascularization. © 2001 Wiley‐Liss, Inc.
Chitosan‐treated polypropylene matrix as immobilization support for lactic acid production using Lactobacillus plantarum NCIM 2084
Authors: Krishnan Sudha , Gowthaman M K , Misra M C , Karanth N G 
Published: August 2002

AbstractAdsorption coupled with electrostatic interaction as an immobilization technique is an important microbial cell immobilization technique. Treatment of the polymer matrix with the cationic surface treating agent chitosan for lactic acid production has been studied. Cells of Lactobacillus plantarum NCIM 2084 were immobilized on a polypropylene (PP) matrix treated with different concentrations of chitosan. The biocatalyst adsorbed on the 1.0 g dm−3 chitosan‐treated PP matrix proved to be most effective. Repeated batch fermentation experiments showed that the immobilized biocatalyst could be recycled effectively 11 times. Studies were also carried out in a packed bed reactor with media recirculation. A high productivity of 7.66 g dm−3 h−1 could be obtained with a conversion of 94% and a yield of 97% at an average residence time of 30 h.© 2001 Society of Chemical Industry
Kinetic study of fast pyrolysis of sawdust in a conical spouted bed reactor in the range 400–500 °C
Authors: Olazar Martin , Aguado Roberto , San José María J , Bilbao Javier 
Published: August 2002

AbstractAn original reactor (a conical spouted bed reactor) is used for the kinetic study of Pinus insignis sawdust pyrolysis in the range 400–500 °C under the usual conditions of this reactor for pyrolysis in a continuous regime. The equipment meets the requirements for pyrolysis kinetic study (bed isothermality, high mass and heat transfer between phases and short residence time of gaseous products). The results of yield of products are evidence of the good performance of the conical spouted bed reactor for obtaining a liquid product, with a maximum yield of 70 wt% in the range 440–460 °C.© 2001 Society of Chemical Industry
Simulation of transient state in enzymatic membrane reactors for resolution of DL‐valine and experimental validation
Authors: Bódalo Antonio , Gómez José L , Gómez Elisa , Máximo M Fuensanta , Hidalgo Asunción M 
Published: August 2002

AbstractA simple model, based on kinetic studies, is shown to be capable of describing the transient state of an ultrafiltration membrane reactor (UFMR) for the continuous resolution of DL‐valine. The reactor has been modelled as a perfectly mixed tank reactor. The model has been validated in different conditions (five different flow rates and three feeding concentrations) using the asymmetrical hydrolysis of N‐acetyl‐DL‐valine catalysed by L‐aminoacylase as experimental system, with an overall mean error of 4.08%.© 2001 Society of Chemical Industry