bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association of Glycated Hemoglobin and Lipid Profile with Peripheral Artery Disease in Metabolic Syndrome Patients from Northwestern Algeria
Authors: Bouragba Imane , Diaf Mustapha , Souiah Sarra , Melih Asmaa , Mellali Attouya 
Published: February 2024

تم إدماج الهيموجلوبين السكري (Hb1Ac) كمؤشر لخلل السكر في الدم بدلا من غلوكوز الدم الصائم (FGB)، لتصنيف المرضى بناء على حوادث الأوعية الدموية ،حيث يرتبطHb1Acارتباطا وثيقا بعوامل الأوعية الدموية مثل سرعة موجة النبض وسمك الوسائط الداخلية، نسبة الألبومين / الكرياتينين (ACR) ومع ذلك فإن العلاقة بينHb1Acونسبة الدهون في تطور أمراض الشرايين لاتزال غير مؤكدة. هدفنا الرئيسي من هذه الدراسة هو التحقيق في ارتباطHb1Acونسبة الدهون مع أمراض الأوعية الدموية الطرفية (PAD) في المرضى الذين يعانون من الاضطراب الأيضي (MetS) في شمال غرب الجزائر. أجريت دراستنا المقطعية لمدة ستة أشهر. تم حساب مؤثر كتلة الجسم كالتالي: (BMI (kg/m²)=weight(kg)/height²(m²، تم استخدام مؤشر الكاحل والعضد (ABI) أقل من 0.9 وتصوير الأوعية لتشخيص PADوحددنا MetS وفقا لمعاييرNECP-ATPIII. تم استعمال اختبار تحليل الارتباط (correlation test) والانحدار الخطي (linear regression) لدراسة الصلة بينHb1Ac، نسبة السكر في الدم، نسب الدهون وحدوث أمراض الشرايين الطرفية لدى الأفراد المصابين بالاضطراب الأيضي. من بين 300 مصاب الاضطراب الأيضي، 53 % تمثل الذكور. لوحظ وجود ارتباطات إيجابية بينHb1Ac،(r=0.753, p<0.001) FGB والتري غلسيريد ((TG (r=0.288, p<0.001) وارتباط سلبي مع البروتين الدهني عالي الكثافة (HDL) (r=-0.356, p<0.001). لم يظهرHb1Ac أي ارتباط مع الكوليسترول الكلي (TC) و البروتين الدهني منخفض الكثافة (LDL). أظهرت نسب الدهون(TG/HDL ,LDL/HDL , TC/HDL) ارتباطات ايجابية مع)Hb1Acr=0.332 r=0.232, r=0.43.(أكد اختبار الانحدار الخطي هذه النتائج. أظهر Hb1Ac ارتباطات ايجابية مع FGB و TG في حين أنه يرتبط سلبا بالبروتين الدهني عالي الكثافة(HDL) . و مستقل عن البروتين الدهني منخفض الكثافة (LDL) والكوليسترول الكلي (TC) و الجدير بالذكر أن نسب الدهون الثلاثة TG/HDL) LDL/HDL , TC/HDL (أظهرت ارتباطات ايجابية معHb1Ac .
Effect of biotic and abiotic elicitors on Salvadora persica callus in vitro
Authors: Jasim Hadaia Y. Jasim , Habeeb Hadeel M. 
Published: February 2024

أجري البحث لغرض دراسة تأثير تراكيز مختلفة من الجسيمات النانوية (الكيتوزان وثاني أكسيد التيتانيوم) و Fusarium oxysporum كمحفزات لزيادة إنتاج المركبات الفعالة من كالس نبات المسواك. اظهرت نتائج المحتوى الكلي مركبات الفلافونويد والقلويدات التي ازاد انتاجها عند اضافة الكيتوسان بتركيز 5 ملغم / لتر، وثاني أكسيد التيتانيوم بتركيز 1 ملغم / لتر، و Fusarium oxysporum بتركيز 5 ملغم / لتر حيث اعطت 93.10 ملغم / 100 ملغم، 128.7 ملغم / 100 ملغم، و 107.61 ملغم / 100 ملغم على التوالي للفلافينودات بينما ساعدت المحفزات على انتاج القلويدات بمعدل 2.39 %، 3.91%، و2.20% على التوالي. وأوضحت النتائج التفوق في وجود مركبات الفلافونويد في العينات مقارنة مع القلويدات. بين تحليل HPLC( تحليل كروماتوغرافي سائل عالي الأداء) اختلافات كبيرة في زيادة إنتاج الفلافونويد (Rutin, Kaempferol, Quercetin, Catechin, Luteolin, and Apigenin) أدت إضافة الكيتوسان عند التركيز 5 ملغم / لتر إلى زيادة إنتاج Rutin ، بمقدار 39.89 ملغم/لتر. أما الكالس المستحث المعالج بثاني أكسيد التيتانيوم بتركيز 1 ملغم/لتر فقد أدى إلى زيادة Rutin بمعدل 35.89 ملغم/لتر. بينما ارتفع إنتاج Rutin إلى 30.12 ملغم/لتر عند معاملته بـ Fusarium oxysporum بتركيز 5 ملغم/لتر.
Effect of using MgO coating with multiple coatings on the optical properties of a five-layer stack
Authors: Al-Assadi Zainab I. 
Published: February 2024

تم استخدام المادة العازلة MgO ذات معامل الانكسار العالي (H) 1.737 مع أربعة مواد عازلة BaF2 (فلوريد الباريوم) و Al2O3 (الألومينا) و GdF3 (فلوريد الجادولينيوم) و LaF3 اللانثانوم فلورايد ذوات معامل انكسار واطيء (L) 1.4825 و 1.5322 و 1.59 و 1.6056 على التوالي كطلاءات بصرية لخمس طبقات وللتصميمين الأول هو ((Glass/H/L/H/L/H والثاني (Glass/L/H/L/H/L) ، باستخدام برنامج MATLAB. تم حساب الخصائص البصرية (M، Rvis.، Rsol.، Tsol.) للطلاءات البصرية الأربعة المتكونة ، وذلك لمعرفة أي طلاء منها كفوء لتلوين زجاج الأنظمة الشمسية المستخدمة كواجهات للأبنية وأيها غير كفوء. تظهر النتائج أنه في التصميم الأول (Glass/H/L/H/L/H) للطبقات الخمس ، يوجد طلاءان فقط لهما كفاءة للتلوين ، وهما الطلاءان (MgO + BaF2) و (MgO + Al2O3) ، لأنهما يحققان القيم المطلوبة من عامل الجدارة (M) والانعكاسية المرئية Rvis. حيث ان القيم المطلوبة لقيم عامل الجدارة (M) و.Rvis والتي تجعل الطلاء كفوءاً للتلوين هي 6% و12% على التوالي ، ولهما قمة انعكاس منتظمة وحادة للتلوين في المنطقة المرئية. في التصميم الأول ، يتناسب معامل الانكسار عكسياً مع الخصائص البصرية للطلاء وبالتالي كفاءة تلوين الطلاء ، مما يعني أن طلاء (MgO + BaF2) أكثر كفاءة من طلاء (MgO + Al2O3) للتلوين. يعتبر التصميم الثاني (Glass/L/H/L/H/L) للطبقات الخمس غير كفوء للتلوين للطلاءات الأربعة ( (MgO + BaF2 ، (MgO+ Al2O3) ، (MgO + GdF3) ، MgO + LaF3)) لأنها لا تمتلك القيم المطلوبة من (M) و . Rvis
A new approach to understand the equilibrium of the voting behaviors and candidates' strategies in the election
Authors: Qi Tiange 
Published: February 2024

Abstract
This paper proposes a hotelling-downs style election competition model to describe the location choice in the political continuum of the political parties using the game theory. Compared to conventional models which only consider two homogeneous parities, this model allows the heterogeneous abilities between two parties and it finds that the party in advantage tends to move to the middle of the continuum while its opposite party tends to be more extreme. Then it turns to three-candidate election where the level of strategic voting depends on the quality of information-how accurate the voters know the votes of each candidate from the survey polls. The candidate in the middle of the continuum can win the election only when it is much better than the other two candidates that there are supporters of either of them strategically vote to it. Finally, the paper applies the model to analyse the elections in Taiwan. It finds that the quality of the information of the election accessible to the voters is relatively high and strategic voting is a common phenomenon since 2012. Therefore, controlling the quality of the information to voters can be a strategy to win the election in the three-candidate election.
An evaluation of Fasciola hepatica HDM-1 mRNA expression in eggs, miracidia and adult flukes and simulation of its internalization pathway
Authors: Jalousian Fateme , Malekzade Parmida , Hosseini Seyed Hossein , Shahbakhsh Mahsa , Shayan Parviz , Rismani Elham , Fathi Saeid , Moghadasi Abdorreza Naser 
Published: February 2024

Abstract
Fascioliasis caused by parasitic flukes of the genus Fasciola. Here, the transcription of FhHDM-1(Fasciola hepatica Helminth Defense Molecule-1) was summarized to show its presence in the developmental stages of Fasciola hepatica (F.hepatica). Structural features were identified by bioinformatics tools as a bioactive-immunomodulator molecule-based therapy. We also simulated peptide initialization by the Linux operating system using GROningen MAchine for Chemical Simulations (GROMACS) and Coarse-grained molecular dynamics (CGMD) Simulation. The final structure of the peptide was extracted from the last frame of the simulation and used as the initial structure for the simulation of protein initialization into the plasma membrane. All HDM clade sequences showed amino acid sequence identity in the sequence part of HDMs, consisting of an N-terminal signal peptide, an α-helical secondary structure, and a C-terminal amphipathic motif when compared with orthologues from other trematodes in databases. The bioinformatics analysis provided stereochemical structures and biochemical features of peptides, showing a relatively appropriate quality for protein biological expression systems. Our findings revealed the presence of FhHDM-1 mRNA in F. hepatica adult flukes and the lack of mRNA in its eggs and miracidia, indicating its central role in the evolution of the parasitic life cycle. The internalization of the peptide into the plasma membrane lipid rafts by the polar heads of lipid molecules and interaction with phospholipids, in turn, results in creating curvature, leading to endocytosis pathways. The possible presenting antigens by MHC classes I and II were identified as overlapping fragments throughout the protein sequence.
Physical Rehabilitation Program for Cardiorespiratory Health and Quality of Life among Breast Cancer Survivors in UAE: Protocol for a Randomized Control Trial.
Authors: Rashid Fatima Abdul , Anwar Wajiha , Kandakurti Praveen Kumar , HAZARI ANIMESH 
Published: February 2024

Abstract
Background
Cancer is a medical condition where some cells of the body reproduce uncontrollably and metastasize to other parts of the body. The burden of the disease is significantly high both at the global and national levels. In UAE, cancer was found to be the third leading cause of death. Breast cancer has been ranked first due to its prevalence, incidence, and mortality in UAE. Breast cancer survivors have significantly poor cardiovascular tolerance which affects their Quality of Life (QoL), even after the carcinoma has been treated or removed. Thus, the protocol aims to analyze the changes in cardiovascular endurance and QoL domains for breast cancer survivors in the United Arab Emirates using a long-term 2-month physical rehabilitation.
Methods
A total of 60 breast cancer survivors would be included in the study using a randomized controlled allocation of a 2-month physical rehabilitation intervention program with three months follow up. The intervention would target the cardiovascular endurance component of the participants to improve their physical well-being and Quality of life ultimately.
Discussion
The findings of the study would have high clinical significance among the breast cancer survivors in UAE. The proposed physical rehabilitation program could be beneficial in improving cardiovascular endurance and thereby reduce the risk of mortality among the breast cancer survivors. In addition, the physiological benefits of the exercise program could improve their Quality-of-Life domains including physical, mental, and social well- being. On a larger view, it could also help to reduce the economic burden on the health system due to associated complications.
Trial Registration:
Clinical trial ID: NCT06013527. Registration date: 28 August 2023.
Medical Students’ Attitude towards Artificial Intelligence in Medicine: A National Multicenter Survey
Authors: Yaynishet Yodit Abraham , Nasir Fuad Menur , Hailu Samuel Sisay , Solomon Daniel Zewdneh , Gidena Eden Kahsay , Bedewi Abdulhamid Mustefa 
Published: February 2024

Abstract

1.1 Objectives

The rapid advancement of Artificial Intelligence (AI) is leading to its integration into various fields, including medicine, which is at the forefront of this development. There are numerous perspectives on the future role of AI in medicine, with varying levels of positivity or negativity. In this study, we aimed to assess undergraduate medical students' attitudes towards integrating AI in medicine, to evaluate their need for AI training, identify misconceptions about AI, and explore its impact on their choice of specialization

1.2 Methods

To assess the attitudes of medical students towards the integration of AI in medicine, a web-based multicenter survey was conducted across both public and private medical institutes in Ethiopia over a three-month period from June to August 2022. The survey questionnaire included questions on the students’ familiarity with AI, perceptions of AI in medicine, and the need for AI training among medical students. Group comparison was tested by chi-square test for categorical responses and Mann-Whitney test for ordinal rating scale responses.

1.3 Results

Of the 1002 respondents, 68.3% were unaware of AI's role in medicine despite over two-thirds (69%) considering themselves tech-savvy; however, a significant majority recognized AI's applications in daily life, particularly through social media (77.6%) and mainstream media (44.9%). Most students (86.9%) believed AI would improve medicine, and notably, 84.9% advocated for its inclusion in medical training, reflecting a strong sentiment that AI education should be a part of the medical curriculum. Over half of the participants (56.8%) felt that AI would positively impact their choice of medical specialty, yet there was a split opinion about the emphasis on AI in developing countries like Ethiopia, with 41.7% preferring not to prioritize it. Students interested in specialties influenced by AI were more inclined to perceive AI as beneficial to medicine, suggesting a correlation between their specialty interests and their views on AI's role in healthcare.

1.4 Conclusions

The research findings indicate that while many students surveyed had limited awareness and basic understanding of medical AI, the majority recognized its significant potential in medicine. Most were not concerned about AI replacing them in the future and agreed that AI will enhance medicine and should be integrated into the medical curriculum.
Is casting of displaced paediatric distal forearm fractures non-inferior to reduction under general anaesthesia? The CASTING trial.
Study protocol for a pragmatic, randomized, controlled non-inferiority multicentre trial
Authors: Abildgaard Katrine Rønn Rønn , Buxbom Peter , Rahbek Ole , Gottliebsen Martin , Gundtoft Per Hviid , Viberg Bjarke , Brorson Stig 
Published: February 2024

Abstract
Background
Treatment of displaced distal forearm fractures in children have traditionally been closed reduction and pin fixation, although they might heal and remodel without surgery with no functional impairment. No randomized controlled trials have been published comparing the patient-reported functional outcome following non-surgical or surgical treatment of displaced paediatric distal forearm fractures.
Methods
A multicentre non-inferiority randomized controlled trial. Children aged 4-10 years with a displaced distal forearm fracture will be offered inclusion, if the on-duty orthopaedic surgeon finds indication for surgical intervention. They will be allocated equally to non-surgical treatment (intervention) or surgical treatment of surgeon’s choice (comparator). Follow-up will be 4 weeks, 3, 6 and 12 months. The primary outcome is the between-group difference in 12 months QuickDASH score. We will need a sample of 40 patients to show a 15-point difference with 80% power.
Discussion
The results of this trial may change our understanding of the healing potential of paediatric distal forearm fractures. If non-inferiority of non-surgical treatment is shown, the results may contribute to a reduction in future surgeries on children, who in turn can be treated without the risks and psychological burdens associated with surgery.
Trial registration
www.clinicaltrials.gov (ID: NCT05736068). Date of registry: 17-02-2023.
Intelligent Vehicle Restriction System Based on Bayesian Optimization
Authors: Zhu Xuguang , Zou Feifei 
Published: February 2024

Abstract
With the rapid development of the economy, the number of private cars has increased significantly, leading to a heightened risk of serious traffic accidents. Therefore, it is imperative to implement measures to restrict the number of vehicles. In this regard, we propose a Support Vector Machine (SVM) model based on Bayesian optimization for vehicle license plate recognition. The experimental results demonstrate the efficacy of this approach. Compared to the conventional SVM model, the Precision and Recall are improved by 15.37% and 18.5%, respectively.
The Immune Response of Boschveld Chickens to a Newcastle Disease Vaccination Program Designed for Commercial Layers
Authors: HODZI PRIDE , Masunda Blessed , MUtibvu Tonderai , Charambira Takudzwa , Mafigu Takudzwa , Nhara Rumbudzai 
Published: February 2024

Abstract
This study evaluated Boschveld chicken’s antibody response to a Newcastle Disease (ND) vaccination program designed for the Hyline Brown chickens. Both chicken breeds were challenged with the LaSota vaccine at days 1, 69, 111, and 195. A total of 160 sera samples were collected, 80 from each breed. The sera were tested for anti-Newcastle Disease Virus (NDV) antibodies using the Haemagglutination inhibition assay. The anti-NDV antibody titers were expressed in log 2 as geometric mean ± standard deviation. Antibody titers were evaluated and compared pre-infection and 10 days post-infection (dpi). Sera positivity to anti-NDV was tested at 10 dpi. A higher percentage of negative sera (6.875) was recorded in Boschveld than in Hyline Brown chickens (3.75). Hyline Brown chicks had a higher antibody titer (4.95 ± 0.21) than Boschveld (3.21 ± 0.43) before any vaccination. There was a significant association (p < 0.05) between the number of vaccinations and antibody titers in both chicken breeds. Sera from the Boschveld reached a higher antibody titer value (13.98) than that of Hyline Brown chickens (13.85). The Boschveld had a higher immune response peak and immunological memory compared to the Hyline Brown chickens. The candidate genes from Boschveld chickens can be introgressed in highly productive chicken germplasm with less NDV response as an alternative solution to ND. The antibody titers of the Boschveld did not change significantly (p > 0.05) after the 4th vaccination time while those from Hyline Brown chickens continued to increase. The 4th ND vaccination must be ignored or delayed in Boschveld chickens.
Potential anti-HIV and antitrypanosomal components revealed in Sorindeia nitidula via LC-ESI-QTOF-MS/MS and molecular docking
Authors: Ebede Guy Roland , Okoro Emeka Emea , Mbing Joséphine Ngo , Olofinsan Kolawole Ayodapo , Erukainure Ochuko Lucky , Betote Patrick Hervé Diboue , Pegnyemb Dieudonné Emmanuel , Choudhary Muhammad Iqbal , Siwe-Noundou Xavier , Ndongo Joseph Thierry 
Published: February 2024

Abstract

Sorindeia nitidula is used by traditional practitioners to treat influenza illnesses with cephalgia and febrile aches. However, the potential active ingredients for its remarkable antioxidant, anti-HIV and antitrypanosomal activities remain unexplored. The present study aims to evaluate the antioxidant, anti-HIV and antitrypanosomal activities of the ethyl acetate extract of S. nitidula (SN) in order to screen out the bioactive compounds and to analyze their possible mechanisms of action. Overall, 21 phenolic compounds were annotated, by using the MS and MS/MS information provided by the QTOF-MS. In vitro assays on the extract revealed potent antioxidant (IC50 = 0.0129 mg/mL), anti-HIV (IC50 = 1.736 mg/mL), antitrypanosomal (IC50 = 1.040 µM) activities. Furthermore, SN did not present cytotoxic effect on HeLa cancer cell lines (IC50 = 0.045 µM). Molecular docking revealed that the potential ligands exhibited strong binding ability and inhibitory activities on trypanosome. The integrated strategy based on LC-ESI-QTOF-MS/MS and molecular docking provided a powerful tool and a multidimensional perspective for further exploration of active ingredients in S. nitidula responsible for the antioxidant, anti-HIV and antitrypanosomal activities.
Facile synthesis of KOH and ball milling co-modified wheat straw-derived biochar for the efficient adsorption of methylene blue in aqueous solution
Authors: Li Huaiyan , Ouyang Kongyong , Weng Xinrui , Wu Lei , Li Xinshun , Shi Yanhong , Zhang Ningyuan , Zhang Yunhua , Li Hui 
Published: February 2024

Abstract
In this study, we developed a novel and cost-effective method for the preparation of KOH-activated pyrolyzed wheat straw biochar composite (KOH-BM-Biochar) using a two-step co-modification approach that involved KOH activation and ball milling. The characterization of KOH-BM-Biochar included assessments of particle size diameter, zeta potential, energy-dispersive secondary electron microscopy, Brunauer-Emmett-Teller theory, X-ray diffraction, Fourier-transform infrared spectroscopy, and X-ray photoelectron spectroscopy. The maximum adsorption capacity of methylene blue (MB) on KOH-BM-Biochar was found to be 300.66 mg·g− 1, and an adsorption efficiency of 95.00% was achieved within 180 minutes at pH 8.0. Kinetic analysis using a pseudo-second-order model (R2 > 0.99) indicated that chemical adsorption was the predominant rate-limiting step. Experimental data fitting to the Temkin and Freundlich isotherm models demonstrated favorable, heterogeneous, and multilayer adsorption. Thermodynamic studies revealed that the adsorption of MB onto KOH-BM-Biochar was endothermic and spontaneous. The adsorption mechanism was attributed to hydrogen bonds, π-π stacking interactions, electrostatic attractions, and heterogeneous diffusion. Overall, this low-cost co-modification method holds significant promise, and KOH-BM-Biochar has emerged as an effective adsorbent for the removal of MB dye from aqueous solutions.
Liguzinediol ameliorates doxorubicin-induced cardiotoxicity and potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis
Authors: Weijie Zhu , Naqi Lian , Jia Wang , Fengming Zhao , Bowen Liu , Jiaxing Sheng , Chenyan Zhang , Xuan Zhou , Wenbai Gao , Chen Xie , Haoyu Gu , Yuxin Zhang , Huimin Bian , Mianli Bian , Miao Jiang , Yu Li 
Published: February 2024

Abstract
Background Liguzinediol (Lig) has emerged as a promising candidate for mitigating Doxorubicin (DOX)-induced cardiotoxicity, a significant limitation in the clinical application of this widely used antineoplastic drug known for its efficacy. This study aimed to explore the effects and potential mechanisms underlying Lig's protective role against DOX-induced cardiotoxicity. Methods C57BL/6 mice were treated with DOX. Cardiac function changes were observed by echocardiography. Cardiac structure changes were observed by HE and Masson staining. Immunofluorescence was applied to visualize the cardiomyocyte apoptosis. Western blotting was used to detect the expression levels of AMPK, SIRT3, Caspase-3 and GSDME. These experiments confirmed that Liguzinediol had a ameliorative effect on DOX-induced cardiotoxicity in mice. Results The results demonstrated that Lig effectively countered myocardial oxidative stress by modulating intracellular levels of reactive oxygen species (ROS), malondialdehyde (MDA), and superoxide dismutase (SOD). Lig reduced levels of creatine kinase (CK), lactate dehydrogenase (LDH), and ameliorated histopathological changes while improving electrocardiogram profiles in vivo. Furthermore, the study revealed that Lig activated the AMP-activated protein kinase (AMPK)/sirtuin 3 (SIRT3) pathway, thereby enhancing mitochondrial function and attenuating myocardial cell apoptosis. In experiments with H9C2 cells treated with DOX, co-administration of the AMPK inhibitor compound C (CC) led to a significant increase in intracellular ROS levels. Lig intervention reversed these effects, along with the downregulation of gasdermin E N-terminal fragment (GSDME-N), interleukin-1β (IL-1β), and interleukin-6 (IL-6), suggesting a potential role of Lig in mitigating Caspase-3/GSDME-mediated pyroptosis. Conclusions The findings of this study suggest that Lig effectively alleviates DOX-induced cardiotoxicity through the activation of the AMPK/SIRT3 pathway, thereby presenting itself as a natural product with therapeutic potential for preventing DOX-associated cardiotoxicity. This novel approach may pave the way for the development of alternative strategies in the clinical management of DOX-induced cardiac complications.