bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autoimmune Thyroid Disease and Myasthenia Gravis: A study bidirectional Mendelian randomization
Authors: Wang suijian , Lin Shaoda , Chen Xiaohong , Chen Daiyun 
Published: October 2023

Abstract
Background
Previous studies have suggested a potential association between AITD and MG, but the evidence is limited and controversial, and the exact causal relationship remains uncertain.
Objective
Therefore, we employed a Mendelian randomization (MR) analysis to investigate the causal relationship between AITD and MG.
Methods
To explore the interplay between AITD and MG, We conducted MR studies utilizing GWAS-based summary statistics in the European ancestry.Several techniques were used to ensure the stability of the causal effect, such as random-effect inverse variance weighted, weighted median, MR-Egger regression, and MR-PRESSO. Heterogeneity was evaluated by calculating Cochran's Q value. Moreover, the presence of horizontal pleiotropy was investigated through MR-Egger regression and MR-PRESSO
Results
The IVW method indicates a causal relationship between both GD(OR 1.31,95%CI 1.08 to 1.60,P = 0.005) and autoimmune hypothyroidism (OR: 1.26, 95% CI: 1.08 to 1.47, P = 0.002) with MG. However, there is no association found between FT4(OR 0.88,95%CI 0.65 to 1.18,P = 0.406), TPOAb(OR: 1.34, 95% CI: 0.86 to 2.07, P = 0.186), TSH(OR: 0.97, 95% CI: 0.77 to 1.23, P = 0.846), and MG. The reverse MR analysis reveals a causal relationship between MG and GD(OR: 1.50, 95% CI: 1.14 to 1.98, P = 3.57e-3), with stable results. On the other hand, there is a significant association with autoimmune hypothyroidism(OR: 1.29, 95% CI: 1.04 to 1.59, P = 0.019), but it is considered unstable due to the influence of horizontal pleiotropy (MR PRESSO Distortion Test P < 0.001). MG has a higher prevalence of TPOAb(OR: 1.84, 95% CI: 1.39 to 2.42, P = 1.47e-5) positivity and may be linked to elevated TSH levels(Beta:0.08,95% CI:0.01 to 0.14,P = 0.011), while there is no correlation between MG and FT4(Beta:-9.03e-3,95% CI:-0.07 to 0.05,P = 0.796).
Conclusion
AITD patients are more susceptible to developing MG, and MG patients also have a higher incidence of GD.
Intelligent Transfer Learning for Bitewing X-Ray Dental Caries Image Classification
Authors: Divakaran Sindu , Vasanth K , Rani Sheela 
Published: October 2023

Abstract
Dental carriers are found in humans as the most common and oldest diseases. Dental caries result from cariogenic bacteria of tooth adherence that cause prevalent chronic infection in teeth by metabolizing sugar for the production of acid that leads to demineralization of tooth structure over time.It is considered a major health problem worldwide almost all adults have the probability of getting affected by dental caries. Bitewing X-ray offers a medical diagnosis of changes below the gum line or decay between the teeth.The main focus of the study is to evaluate the application of deep learning models that include the Naïve Bayes classifier,K-Nearest Neighbour, and transfer learning like LeNet,VGGnet,ShuffleNet, and MobileNetfor the classification of by being X ray dental carries images.AI can provide an assistive diagnosis in the automatic detection of complex images efficiently in intraoral radiography for providing effective patient care.
Which is the safe position of femoral component in coronal plane in mobile-bearing unicompartmental knee arthroplasty? a finite element-based study
Authors: Li Chao , Cheng Jingbo , Feng Mingli 
Published: October 2023

Abstract
Background
Apply finite element analysis to explore the influence of different femoral prosthesis positions on the stress of the polyethylene bearing to determine the safe position of the femoral prosthesis in mobile-bearing Unicompartmental Knee arthroplasty.
Methods
A normal knee joint model was established and verified. The femoral component were designed with intorsion13 °,intorsion6 °, 0°(neutral position),extorsion6°,extorsion13°,and were combined into 5 three⁃dimensional finite element models of medial unicompartmental knee arthroplasty. A 1000 N load was applied along the femoral mechanical axis. The von Mises cloud stress distribution was observed. Moreover, the high contact stress of femoral prosthesis, the lateral compartment load ratio, the upper surface of the polyethylene liner, and the femoral cartilage in the lateral compartment was measured. Compared with the neutral position (6°and 13°intorsion or extorsion of the femoral prosthesis) to find the appropriate position of the femoral component.
Results
The maximum contact stress of the femoral prosthesis from the neutral position to the internal and external rotation of the femur, tibia prosthesis and meniscal liner gradually increase. When the femoral prosthesis internal and external rotation at 13°,the maximum contact stress of the femoral prosthesis increased by 3.21 MPa and 1.17 MPa, respectively, the maximum contact stress of the polyethylene liner increased by 4.46 MPa and 3.22 MPa, respectively. The maximum contact stress increased with the internal and external rotation angles, which suggested that it was unsafe for the femoral prosthesis to rotate within 10°.
Conclusion
Static knee biomechanics after mobile bearing unicompartmental knee arthroplasty can be affected by femoral component alignment༎During unicompartmental knee arthroplasty surgery, femoral prosthesis rotations within 10°are cannot be considered as appropriate for placing the femoral prosthesis in mobile—bearing unicompartmental knee arthroplasty, femoral prosthesis rotations more than 6°will increasing the risk of postoperative complications and may reduce the long-term survival rate of the prosthesis.
Predicting Liver Metastasis in Pancreatic Neuroendocrine Tumor After Surgery: A Population-Based Study
Authors: Wang Yizhi , Kong Yang , Yang Qifan , Zhou Dongkai , Wang Wei-Lin 
Published: October 2023

Abstract
Background The occurrence of liver metastasis in pancreatic neuroendocrine tumor (pNET) after primary site surgery significantly hampers the improvement of patient’s overall survival (OS). Therefore, it is necessary for early detection of metastatic lesions. However, the relationship between clinical variables and the liver metastasis potential remains obscure. Methods Detailed information of pNET patients received primary site surgery was retrieved from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2019. Univariate and multivariate logistic regression analysis were recruited to generate independent risk factors of liver metastasis to construct a model presented as a nomogram using training cohort of SEER database. Moreover, a testing cohort from SEER database and a cohort of 96 patients from Second Affiliated Hospital of Zhejiang University School of Medicine were further recruited for internal and external verification respectively. The receiver operating characteristic curve, calibration curve, decision curve analysis (DCA) and clinical impact curve (CIC) were used to evaluate the accuracy, reliability and clinical application value respectively. The risk subgroups were finally generated according to the score of the nomogram. Results 2458 pNET patients were included in the present study. And 1638 of them were assigned as training cohort and 820 of them were assigned as testing cohort. Tumor size, AJCC T stage, functional status and other site metastases were considered as independent risk factors of liver metastasis via multivariate logistic regression analysis (all, p < 0.05). Our nomogram showed an excellent accuracy with the area under curve (AUC) of 0.821 in training cohort, 0.766 in testing cohort and 0.817 in validation cohort, respectively. Moreover, the calibration curve, DCA and CIC indicated a better net benefit and clinical application value in training cohort, testing cohort and validation cohort compared with single variate. Finally, pNET patients could be classified into low, medium and high risk of liver metastasis. Patients with high risk of liver metastasis showed a significant poorer OS compare to other two groups. Conclusion Tumor size can be an important predictor of liver metastasis in pNET patients. The nomogram we established could predict liver metastasis of pNET patients after surgery accurately.
Safety and Effectiveness of Multimodal Opioid-Free Anesthesia for Pain and Recovery after Laparoscopic Surgery: A Systematic Review and Meta- Analysis
Authors: Cheng Lin , Liu Jiang , Qin Sifan , Geng Xinyan , Zhang Limin , Fang Shirong 
Published: October 2023

Abstract
Background
Multimodal Opioid-free anesthesia (OFA), a new anesthetic strategy, is always controversial for relieving postoperative pain in patients undergoing laparoscopy. The aim of this study was to investigate the safety and effectiveness of OFA compared to conventional opioid anesthesia (OA) in postoperative pain management and recovery in patients undergoing laparoscopic surgery.
Methods
This systematic review is registered on PROSPER. The databases of PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to September 2023. The study selection, data extraction, and risk of bias assessment were independently conducted by two reviewers. The primary outcomes included postoperative pain scores at 2h and 24h, postoperative analgesic consumption, Quality of recovery (QoR-40) scores, and the incidence of Postoperative Nausea and Vomiting (PONV) and other complications. The risk of bias was assessed using RoB 2.0, and meta-analysis was carried out using random effects models.
Results
Ultimately, 12 studies involving 983 patients undergoing laparoscopic surgery were included in this systematic evaluation and meta-analysis. The results of the meta-analysis showed that OFA significantly reduced early postoperative pain response in laparoscopic patients compared with conventional OA. OFA also reduced the incidence of PONV and the consumption of analgesics and antiemetics and improved the subjective quality of recovery in patients. The other variables presented no significant differences between the groups or were unable to be analyzed.
Conclusions
OFA may be more beneficial for postoperative pain management and recovery in patients undergoing laparoscopic surgery compared with conventional OA. Future studies could further extend these findings to other surgical populations.
Hemovigilance- Recipient and Donor Reaction Reporting: An Active Surveillance
Authors: Potdar Amruta Ashok , Prakash Pallavi , Ramesh Madhan , Syed Jehath , Chalasani Sri Harsha 
Published: October 2023

Abstract
Background
Hemovigilance involves the identification, monitoring, reporting, and analysis of adverse events related to blood transfusion and donation.
Aims
To determine the pattern, incidence and causality of transfusion-related reactions
Methods
A prospective, active surveillance study was conducted over a period of six months. All patients of any sex admitted to various specialties who received blood or blood components and reported to have had transfusion reactions during or after transfusion were included in the study. The causative component, category, severity, and causality of the reactions were evaluated using the National Institute of Biological Scale. Data were analyzed categorically and are presented as n (%).
Results
A total of 5274 units were transfused during the study period, with [3494 (66.25%)] units transfused to male patients and [1780 (33.75%)] units to female patients. Packed red blood cells (PRBCs) were the most frequently transfused [2664 (50.5%)]. Of all the transfusions, 28 (0.53%) transfusion reactions (TR) were identified and reported. The most common TR recorded was febrile non-hemolytic transfusion reactions [20 (71.42%)], followed by allergic transfusion reactions [7 (25%)]. Most TRs were associated with PRBC transfusions [18 (64.28%)]. The causality of the [19 (67.85%)] reactions was identified as definite. A total of 2194 blood donations were recorded, of which [21 (0.95%)] donor reactions were reported.
Conclusion
The incidence of transfusion and donor reactions was 0.53% and 0.95%, respectively. A clinical pharmacist may assist in the active surveillance of TRs and assignment of the pattern of transfusion reactions.
Pengaruh Pemberian Madu Trigona Terhadap Perbaikan Tes Fungsi Hati Tikus yang Mengalami Drug-induced Liver Injury
Authors: Pramono Sigit Dwi Pramono , Natzir Rosdiana , Kadir Syahrijuita , Soraya Gita Vita , Cangara Muhammad Husni , Bahar Burhanuddin 
Published: October 2023

Drug-induced Liver Injury (DILI) dapat disebabkan oleh penggunaan obat seperti acetaminophen yang mengalami metabolisme di hati. Kerusakan hati dideteksi melalui peningkatan enzim transaminase. Madu trigona mengandung flavonoid yang tinggi dan memiliki peran protektif terhadap inflamasi dan stres oksidatif. Penelitian ini bertujuan mengetahui efek pemberian madu trigona sebagai hepatoprotektor terhadap kadar enzim transaminase tikus Sprague-Dawley (SD) yang diinduksi acetaminophen. Penelitian ini menggunakan desain post-test with control group design dimana 12 ekor Rattus norvegicus galur SD dibagi dalam empat kelompok: kontrol negatif, kontrol positif, perlakuan 1 dan perlakuan 2. Semua kelompok kecuali kontrol negatif diinduksi acetaminophen selama 7 hari dilanjutkan pemberian madu kelulut pada kelompok perlakuan 1 dan 2 dengan dosis masing-masing 9,3 g/kgBB dan 18,6 g/kgBB selama 7 hari. Pengukuran ALT dan AST pada hari ke-1, ke-8 dan ke-15 menggunakan spektrofotometri. Uji statistik menggunakan One Way Anova. Hasil penelitian didapatkan perbedaan signifikan kadar ALT (nilai p=0,000) dan AST (nilai p=0,000) pada hari ke-15 antara kelompok yang diberikan madu trigona dengan tidak diberikan setelah diinduksi acetaminophen. Sebagai kesimpulan, madu trigona memiliki efek hepatoprotektor menurunkan kadar ALT dan AST.
Penurunan hs-CRP Tikus Sprague dawley Jantan Setelah Pemberian Madu Hutan Apis Dorsata
Authors: Musa Inna Mutmainnah , Bukhari Agussalim , Idris Irfan , Yustisia Ika , Natzir Rosdiana , Aminuddin Aminuddin , Hardjo Marhaen 
Published: October 2023

Pola konsumsi makanan berlemak berlebih menimbulkan berbagai gangguan metabolik dan inflamasi sistemik sehingga memicu peningkatan penanda inflamasi, yaitu high sensitivity C-Reactive Protein (hs-CRP). Madu hutan Apis dorsata mengandung antioksidan tinggi, namun belum banyak penelitian mengenai aktifitas antioksidan madu hutan ini terhadap perubahan kadar hs-CRP di dalam darah. Penelitian bertujuan untuk mengetahui pengaruh pemberian madu hutan Apis dorsata terhadap kadar serum hs-CRP tikus Sprague dawley jantan diinduksi pakan tinggi lemak (PTL). Rancangan penelitian yaitu pre-post test with control group design. 15 ekor tikus jantan Sprague dawley dibagi dalam tikus kelompok kontrol negatif (K-), kontrol positif (K+) diinduksi PTL, dan perlakuan (P) diinduksi PTL + madu hutan Apis dorsata dosis 0,5 ml/200 g BB. Induksi PTL diberikan selama 30 hari dan madu selama 7 hari. Serum hs-CRP diambil dua kali, yaitu setelah pemberian PTL dan setelah pemberian madu, kemudian diukur menggunakan metode ELISA. Hasilnya menunjukkan kelompok tikus yang diberi PTL+intervensi madu hutan mengalami penurunan kadar hs-CRP yang signifikan (p=0,009). Hal ini menandakan efek antioksidan dan antiinflamasi pada madu hutan Apis dorsata dapat menurunkan kadar hs-CRP. Kesimpulannya, Madu hutan Apis dorsata dosis 0,5 ml/200 g BB mampu menurunkan kadar serum hs-CRP tikus Sprague dawley jantan yang diinduksi pakan tinggi lemak.
Hubungan Lingkungan Sosial dengan Motivasi Belajar Remaja di Dusun V Desa Tanjung Anom Kecamatan Pancur Batu
Authors: Purba Sahril M , Nainggolan Elizon 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara lingkungan sosial dengan motivasi belajar remaja di dusun v desa tanjung anom. Penelitian menggunakan jenis penelitian deskritif asosiatif. Berdasarkan data pengujian hipotesis diperoleh bahwa hubungan lingkungan sosial dengan motivasi belajar remaja sebesar 0,625. Selanjutnya hasil perhitungan uji hipotesis dengan menggunakan uji t diperoleh harga sebesar 6,10. Harga dengan dk = 60 dan taraf signifikan 95% yaitu = 2,39. Dengan demikian jika dilakukan perbandingan diperoleh 6,10 >2,39 oleh karena itu, hipotesis penelitian diterima atau dapat disimpulkan bahwa ada hubungan lingkungan sosial dengan motivasi belajar remaja di Dusun V Desa Tanjung Anom Kecamatn Pancur batu.
Upaya Tokoh Masyarakat Dalam Meningkatkan Pembangunan Ekowisata Tangkahan di Desa Namusialang Kecamatan Batang Serangan Kabupaten Langkat
Authors: Matondang Cici Pratiwi 
Published: October 2023

Tujuan dari penelitian ini adalah; 1)untuk mengetahui gambaran tentang kondisi ekowisata tangkahan yang ada di desa namusialang sebelum tokoh masyarakat terlibat dalam pembangunan ekowisata tangkahan, 2)untuk mengetahui upaya masyarakat dalam meningkatkan pembangunan ekowisata tangkahan, 3)untuk mengetahui hasil pembangunan ekowisata tangkahan sebelum tokoh masyarakat terlibat dalam pembangunan. Penelitian ini menerapkan pendekatan deskriptif kualitatif. Subjek dalam penelitian ini adalah Tokoh Masyarakat yang ada di desa Namusialang. Pengambilan subjek dalam penelitian ini secara purposive yakni sebanyak 3 orang. Teknik pengumpulan data melalui wawancara, observasi, dan dokumentasi. Teknik analisis data digunakan dengan reduksi data, penyajian data, penarikan kesimpulan. Hasil penelitian menunjukkan upaya tokoh masyarakat dalam meningkatkan pembangunan ekowisata sangat baik. Kondisi ekowisata tangkahan di desa namusialang mengalami perubahan seperti sudah bagusnya jalan dan tempat lokasi parkir di tangkahan juga sudah diperluas, tokoh agama juga berhasil membuat tangkahan tidak menjadi tempat pengunjung melakukan hal-hal yang dilarang oleh agama.
Analysis of Coconut (Cocos Nucifera L) Commodities Based on Land Suitability in the Pining District of Gayo Lues
Authors: Lindawati Lindawati , Alfiansyah Ikhwan , Madiyoh Abdulhakim 
Published: October 2023

Using a survey method, this study aimed to examine the characteristics of the land and the direction of land usage for cultivating coconuts. The land's features are described in a land map created from the overlapping findings of each land map unit, which serves as a foundation for additional study to fit the environment for growing coconut plants. According to the results of the analytics and planning of the land conservation of coconut crops in Gayo Luwes, for the crops to survive, it is vital to pay attention to soil characteristics such as temperature, rainfall, soil type, and the number of wet months. Gayo Luwes District is a coconut region in the centre of the country. Not only were the results of matching for the coconut commodity in each SST obtained by using map-based planning geographic information systems, but it was also discovered that rainfall ranged from 3100 mm/year, temperatures went from 23oC to 24oC, base saturation was in the very low to low category (3.91% -35.16%), pH H2O is classified as acidic (4.6-4.9), drainage is slightly obstructed, relatively fast and good, slopes are sloping to steep (12%-26 ) and textures with values little fine, smooth and rather rough are the limiting factors dominant. Other findings also suggest that applying organic material in garbage and compost to Red Yellow Podzolic soil in Batanghari, Jambi, increases Ca-dd and base saturation, and liming is done to raise the pH of H2O in soil units. Moderate to high levels of management can improve the slope limiting factor, such as delaying erosion, establishing a terrace, planting according to the contour, and growing covering plants. Irrigation and irrigation systems can assist in increasing the factors that limit rainfall.Â Keywords: Development, Coconut, Land Suitability, Gayo Lues
Pengaruh Pelatihan Membuat Minuman Lidah Buaya Terhadap Kemampuan Berwirausaha Ibu Rumah Tangga Di Desa Paya Bakung Kecamatan Hamparan Perak Kabupaten Deli Serdang
Authors: Nainggolan Elizon , Wulandari Nurjanah 
Published: October 2023

Penelitian ini dilkukan dengan rumusan masalah sebaik apa perubahan sikap berwirausaha peserta pelatihan membuat minuman lidah buaya yang diikuti ibu rumah tangga, tujuan dalam penelitian ini ialah untuk mengetahui pengaruh pelatihan membuat minuman lidah buaya terhadap kemampuan berwirausaha ibu rumah tangga, dimana tingkat kehidupan ekonomi di desa Paya Bakung terbilang rendah maka peneliti melakukan penelitian tersebut. Sampel penelitian berjumlah 50 IRT yang diambil dengan menggunakan teknik random sampling, Data dikumpulkan dengan menggunakan angket kemudian data penelitian ini di analisis dengan menggunakan teknik analisis produk dari uji korelasi dan uji hipotesis lalu dianalisis dengan menggunakan regresi linier sederhana. Hasil penelitian menunjukan pelatihan keterampilan Ibu Rumah Tangga (IRT) Desa Paya Bakung Kecamatan Hamparan Perak berpengaruh signifikan terhadap minat berwirausaha dengan besaran signifikan senilai 0,62 sama dengan 62%. Dimana variabel X mempengaruhi variabel Y Sehingga ditarik kesimpulan bahwa pelatihan membuat minuman lidah buaya berpengaruh secara signifikan terhadap kemampuan berwirausaha Ibu Rumah Tangga di desa Paya Bakung Kecamatan Hamparan Perak, dengan nilai t hitung 5,452 ≥ 2,021
Pemberdayaan Masyarakat Melalui Program Pendidikan Kecakapan Wirausaha (PKW) Tanaman Hidroponik di SPNF SKB Wilayah 1 Kota Padang
Authors: Nainggolan Lilis Swarni , Rohman Arif Nur 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui manfaat dari dilaksanakannya program Pendidikan Kecakapan Wirausaha (PKW) Tanaman Hidroponik di SPNF SKB Wilayah 1 Kota Padang. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data yang digunakan yaitu observasi, wawancara dan studi dokumentasi. Subyek daripenelitian ini yaitu peserta didik yang mengikuti program Pendidikan Kecakapan Wirausaha (PKW) Tanaman Hidroponik di SPNF SKB Wilayah 1 Kota Padang serta Narasumber pelatihan tersebut. Hasil dari penelitian ini menunjukan bahwa dilaksanakannya program Pendidikan Kecakapan Wirausaha (PKW) Tanaman Hidroponik di SPNF SKB Wilayah 1 Kota Padang memiliki banyak sekali manfaatnya diantaranya yaitu membangun jiwa kewirausahaan pada peserta didik untuk mengembangkan perekonomian didaerahnya.