bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostate cancer mortality time trends in BRICS, from 1990 to 2019: an age- period-cohort analysis for the Global Burden of Disease 2019
Authors: Feng Lijuan , He Jing , Chen Qianjuan , Xie Shudong , Gao Ting , Wu Yuhang , Long Liling 
Published: October 2023

Abstract
Purpose
Currently, Prostate cancer contributes to a growing disease burden. However, limited research has assessed Prostate cancer trends in Brazil, Russia, India, China, and South Africa (BRICS). The objective is to report the trends in Prostate cancer mortality across BRICS from 1990 to 2019, along with the age-period-cohort effects.
Methods
The relevant data was sourced from the Global Burden of Disease Study 2019 and an age-period-cohort model was used to calculate net drifts (overall annual percentage change), local drifts (annual percentage change in each age group), longitudinal age curves (expected longitudinal age-specific rate), and period (cohort) relative risks.
Results
In 2019, the global mortality of Prostate cancer increased by 108.94% compared to 1990; but the age-standardized mortality rate has decreased by 9.46%. Between 1990 and 2019, India experienced the greatest reduction in age-standardized mortality rate. South Africa and Russia have experienced an increase in age-standardized mortality rate. The mortality rate of Prostate cancer increased with advancing age. The period and cohort risks of Prostate cancer mortality have generally shown improvement across BRICS. However, the temporal effect in the later periods for Russia is not significant, and the cohort risk of Prostate cancer mortality for the Brazilian cohort born in the 1980s is higher.
Conclusions
The BRICS have achieved commendable progress in controlling Prostate cancer mortality. However, the disease burden of Prostate cancer remains substantial in BRICS. The Prostate cancer mortality vary significantly among these countries; therefore, it is advisable for BRICS to formulate effective policies based on their national circumstances.
Macroscopic type is implicated in the prognostic impact of initial chemotherapy on peritoneal lavage cytology-positive gastric cancer with no other noncurative factors
Authors: Kano Yosuke , Ichikawa Hiroshi , Aizawa Masaki , Muneoka Yusuke , Usui Kenji , Hanyu Takaaki , Ishikawa Takashi , Yabusaki Hiroshi , Kobayashi Kazuaki , Kuwabara Shirou , Makino Shigeto , Kawachi Yasuyuki , Miura Kohei , Tajima Yosuke , Shimada Yoshifumi , Sakata Jun , Wakai Toshifumi 
Published: October 2023

Abstract
Background
Initial chemotherapy (Initial-C) followed by surgery is a promising treatment strategy for peritoneal lavage cytology-positive gastric cancer (CY1 GC) with no other noncurative factors. The aim of this study was to investigate the survival advantage of Initial-C compared to initial surgery (Initial-S) for this disease according to the macroscopic type, which was associated with prognosis and the efficacy of chemotherapy in GC.
Methods
One hundred eighty-nine patients who were diagnosed with CY1 GC with no other noncurative factors at four institutions from January 2007 to December 2018 were enrolled. The patients were divided into a macroscopic type 4 group (N = 48) and a non-type 4 group (N = 141). The influence of initial treatment on overall survival (OS) in each group was evaluated.
Results
In the type 4 group, the 5-year OS rates of Initial-C (N = 35) and Initial-S (N = 13) were 11.6% and 0%, respectively (P = 0.801). The multivariate analysis could not show the survival advantage of Initial-C. In the non-type 4 group, the 5-year OS rates of Initial-C (N = 41) and Initial-S (N = 100) were 48.4% and 29.0%, respectively (P = 0.020). The multivariate analysis revealed that Initial-C was independently associated with prolonged OS (hazard ratio, 0.591; 95% confidence interval, 0.375–0.933: P = 0.023).
Conclusions
Initial-C improves the prognosis of non-type 4 CY1 GC with no other noncurative factors. On the other hand, further development of effective chemotherapeutic regimens and innovative treatment strategies are required for type 4 CY1 GC.
How does Social Integration Affect the Health of the Older Floating Population in China: New Changes in the Structure of the Older Floating Population in China
Authors: Zhang Ping , Ao Yuqi 
Published: October 2023

Abstract
Background
With the gradual liberalization of China's household registration system and the increasing rate of urbanization, the structure of its floating population has undergone significant changes. The once dominant group of migrant workers has given way to a new group of highly educated talents accompanying the older individuals, while the older floating population, including those accompanying the older people, often suffers from insufficient social integration, resulting in the migration attrition effect.
Methods
Based on CMDS2017 data, this paper explores the relationship between social integration and the physical and mental health of the older floating population through the entropy method and two-stage least squares.
Results
We have uncovered a significant positive association between the degree of social integration of China's older floating population and their physical and mental health status. Moreover, our analysis reveals that participation in health education and willingness to stay serve as mediating factors in the process by which social integration affects the physical and mental health of this population. Heterogeneity analysis further shows that the impact of social integration on health status is more pronounced among older migrants with labor migration experience, rural household registration, low educational attainment, and poor family economic status.
Conclusion
We recommend that the Chinese government take proactive measures to promote the social integration of the older floating population in areas experiencing net population inflow, through community mobilization and activities, and by raising awareness of the older floating population among society at large. Ultimately, to mitigate social inequality and the urban-rural gap, the household registration system should be gradually relaxed.
Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms
Authors: Holl Kristin , Chatain Nicolas , Krapp Susanne , Baumeister Julian , Maié Tiago , Scheufen Anja , Brock Nathalie , Koschmieder Steffen , Moreno-Andrés Daniel 
Published: October 2023

Abstract
Myeloproliferative neoplasms (MPNs) encompass a diverse group of hematologic disorders driven by mutations in JAK2, CALR, or MPL. The prevailing working model explaining how these driver mutations induce different disease phenotypes is based on the decisive influence of the cellular microenvironment and the acquisition of additional mutations. Here, we report increased levels of chromatin segregation errors in hematopoietic cells stably expressing CALRdel52 or JAK2V617F mutations. Our investigations employing murine 32DMPL and human erythroleukemic TF-1MPL cells demonstrate a link between CALRdel52 or JAK2V617F expression and a compromised spindle assembly checkpoint (SAC), a phenomenon contributing to error-prone mitosis. This defective SAC is associated with imbalances in the recruitment of SAC factors to mitotic kinetochores upon CALRdel52 or JAK2V617F expression. We show that JAK2 mutant CD34 + MPN patient-derived cells exhibit reduced expression of the master mitotic regulators PLK1, aurora kinase B and PP2A catalytic subunit. Furthermore, the expression profile of mitotic regulators in CD34 + patient-derived cells allows to faithfully distinguish patients from healthy controls, as well as to differentiate primary and secondary myelofibrosis from essential thrombocythemia and polycythemia vera. Altogether, our data suggest alterations in mitotic regulation as a potential driver in the pathogenesis in MPN.
Enhancing Post harvest Longevity of Tomatoes through Synergistic interaction of nano-Clay and TiO 2 in an active packaging film: Mechanical, permeability and photocatalytic properties
Authors: Bodaghi Hojatollah 
Published: October 2023

Abstract
Tomato (Lycopersicon esculentum), a valuable economic crop worldwide, often goes to waste due to improper packaging and handling. This study explores the potential of clay and titanium dioxide (TiO2) nanoparticles in the development of active packaging films for maintaining the quality of tomato fruits over a 42-day period at 4°C. Nanocomposite films were created by incorporating 3% clay (Closite 20A) and 3% TiO2 nanoparticles into low-density polyethylene (LDPE).Transmission electron microscopy (TEM) confirmed the degree of dispersion and exfoliation of the nanoparticles. The mechanical properties of these films demonstrated significant improvements in Young's modulus and tensile strength. The addition of clay nanoparticles led to reduced permeability of CO2, O2, and water vapor. Ethylene production was reduced in fruits packed with nanocomposite films compared to those packaged in LDPE. The combination of clay and TiO2 nanoparticles effectively reduced weight loss, maintained pH, titratable acidity (TA), total soluble solids (TSS), and firmness. Additionally, it enhanced membrane stability, reduced membrane lipid peroxidation, and enhanced the activities of antioxidant enzymes, catalase (CAT) and ascorbate peroxidase (APX) in fruits. Overall, this study highlights the benefits of using clay and TiO2 in active packaging to preserve tomato quality and extend postharvest storage life.
Dual horizon peridynamic approach for studying the effect of porous media on the dynamic crack growth in brittle materials
Authors: Altay Ugur , Dorduncu Mehmet , Kadioglu Suat 
Published: October 2023

Abstract
This study aims to investigate the effect of the stop-hole configurations on dynamic cracks using the Dual Horizon Peridynamic approach (DHPD). The traditional PD formulations require uniform discretization for the solution domain. Therefore, in order to investigate the effect of the stop holes with traditional PD, more densely spaced points are used to represent the holes. If less densely spaced points are used in traditional PD, this may lead to unexpected crack initiations around the stop holes due to strain concentrations originating from the shape of stair steps. If non uniform point spacing is used for representing the outer edge of stop hole accurately in traditional PD, ghost force problem may occur and the forces of the points in the bond may not interact in pairs. Moreover, the use of fine mesh causes high computational efforts. Therefore, the DHPD, which allows non-uniform point spacings unlike traditional PD, is employed for examining the characteristics of dynamic crack propagation in the presence of stop holes. Before stop-hole configurations are examined, the developed DHPD code is validated with the results of a reference solution for the Kalthoff-Winkler test. After the validation process for DHPD code is successfully completed, the crack paths in the stop hole configurations obtained by DHPD are compared with the experiments, and a good agreement between the test and simulation is achieved. Furthermore, the performances of the stop hole configurations are investigated by DHPD in terms of increasing fracture toughness of brittle material. Besides, the effect of crack branching on dynamic crack retardation is also examined. Results of dynamic crack propagation simulated by DHPD are compared with the experimental observations and reference results. The results of DHPD are in good agreement with the experimental observations available in the existing literature.
An Onsite Risk Assessment of Water Quality and Heavy Metal Contamination in Kandal Kampong Speu and Kampong Chhnang Province of Cambodia. (Invited article)
Authors: Song Minjung , Yang Daejeong , Ramu Adam Gopal , Choi Dongjin 
Published: October 2023

Abstract
This research aims to evaluate the onsite risk assessment of water quality and heavy metal pollution in Cambodia's remote Northeast. Tube wells (n = 20), and lakes/ponds (n = 20) were among the many water sources sampled in Kandal and Kampong province. A series of in-situ measurements such as pH, ORP, dissolved oxygen (DO), turbidity (NTU), conductivity (EC), total dissolved solids (TDS), salinity, Total hardness, nitrate (NO32−), nitrite (NO2−) and heavy metals As, Fe, Mn, Cd, Co, Ni, Pb and Zn were measured during the sample collections. The additional chemical assessment was analyzed by using Ion chromatography (IC). Furthermore, The E. coli and Total coliform were analyzed as per scientific guidelines. It was found that the pH of water in all sources was under Cambodian water standards. Water samples from 100% of tube wells, and 98% of lake/pond water exceeded the Cambodian standard of 5 NTU for turbidity. Additionally, parameters like turbidity, electrical conductivity (EC), total suspended solids (TDS), and salinity in tube wells significantly surpass those in lake water. In particularly Kampong Chhnang province, trace metals arsenic (As) and Manganese (Mn) in all samples have been found to exceed Cambodian aesthetic values and the World Health Organization's. Iron (Fe) concentrations in tube wells and lake water samples were also higher than the Cambodian aesthetic standard of 300 ppb. The E. coli and Total coliform in the water samples were terribly higher than the World Health Organization's drinking water quality recommendation in Cambodia. To reduce the dangers to public health from drinking water contamination, it is advised that the people of Kandal and Kampong province have access to suitable treatment technology.
Evaluation of Medication Reconciliation Process Among Home Medication, Hospital Admission, Transition Across Different Wards, and Discharge in Mizan Tepi University Teaching Hospital South West Ethiopia: A Prospective Cross-Sectional Study
Authors: Dereje Mekuriaw 
Published: October 2023

Abstract
Background: - Medication errors are common to occur most frequently during the prescribing and administering transition of care, contribute to adverse drug events in part through medication discrepancies, and this is due to the absence or under-implementation of medication reconciliation, furthermore, Current evidence conducted across the world is limited only to evaluate medication reconciliation and to classify medication discrepancies at admission, discharge and home medication, missing discrepancies during admission to different ward of the hospital
Objective: This study aimed to evaluate of medication reconciliation process among home medication, hospital admission, transition across different wards, and discharge in Mizan Tepi university teaching hospital South West Ethiopia from July 03 to September 02, 2022.
Methods and Materials: - A prospective cross-sectional study was conducted at the medical ward of Mizan Tepi university teaching hospital. from July 03 to September 02, 2022. A total of 59 patients and medical records were included in the study. The data were collected using structured data collection tools developed from different literature and guidelines. The collected data were coded, entered, and analyzed using a Statistical Package for Social Sciences (SPSS, version 23).
Result:Out of 59 study participants, medication discrepancies were detected in 56 of the study group, and from 893 medication patients taking 518 medication discrepancies were identified and 96,149 and 1 unintentional medication discrepancies were identified at transition A, B, and C respectively.
Conclusion; The medication reconciliation process should be implemented in terms of a multidisciplinary approach and also MR process should be incorporated in the hospital as one part of the standard treatment guideline in order to overcome good patient recovery outcomes, and patients should be aware of some home PO medication that should they continue while they are admitted.
Fabricating high-purity graphite disk electrodes as a cost-effective alternative in fundamental electrochemistry research
Authors: Spallacci Claudia , Görlin Mikaela , Kumar Amol , Cheah Mun Hon 
Published: October 2023

Abstract
Graphite electrodes offer remarkable electrochemical properties, emerging as a viable alternative to glassy carbon (GCE) and other carbon-based electrodes for fundamental electrochemistry research. We report the fabrication and characterization of high-purity graphite disk electrodes (GDEs), made from cost-effective materials and a solvent-free methodology employing readily available laboratory equipment. Analysis of their physical properties via SEM, EDX and XPS reveals no metallic interferences and a notably high porosity, emphasizing their potential. The electrochemical performances of GDEs were found to be comparable to those of GCE. Immobilization of peptides and enzymes, both via covalent coupling and surface adsorption, was used to explore potential applications of GDEs. Enzyme activity could be addressed both via direct electron transfer and mediated electron transfer mechanism, indicating the suitability of GDEs to address enzyme activity. These results highlight the interesting properties of our GDEs and make them a low-cost alternative to other carbon-based electrodes, with potential for future real-world applications.
A first assessment of community values, rules and knowledge of Mount Hermon, Lebanon: key perspectives towards biocultural conservation
Authors: Baydoun Safaa , Hani Nizar , Zein Hicham El , Zaidan Rouaa , Ghanem Hassana , Mhanna Mounir , Chalak Lamis 
Published: October 2023

Abstract
Mount Hermon, Lebanon, is a biodiversity hotspot of high cultural value making biocultural perspective highly relevant towards conservation context of this mountain territory. This study aims at identifying a community values, rules and knowledge (VRK) framework heuristic for decision-making. Semi-structured interviews with 126 local informants were conducted during 2022–2023. Findings illustrate that while instrumental values (e.g. water source through snow melt and rain, tourism and recreational activities, land and soil for crop production) were most frequently expressed by informants (63% of expressions), relational values (e.g. social identity, sense of place, spiritual way of life) representing preferences, principles, and virtues about human-nature relationships scored second but still high (41.72%) and subjective intrinsic values of nature (e.g. right to exist) as an end in itself followed last (7.65%). Co-occurrence of formal (indicated by 62.26% of the informants) and informal rules (indicated by 37.74% of the informants) with informants having prevalent local ecological knowledge in resource use were identified in a 70.27% of the informants. Grouping by PCA method demonstrates five strong correlations of enabling or conflicting interactions within the VRK framework that merit close consideration for a meaningful participatory conservation strategy of both biodiversity and cultural diversity in a key hotspot.
On a roll – a direct comparison of extraction methods for the recovery of eDNA from roller swabbing of surfaces
Authors: Guthrie Austin M. , Nevill Paul , Cooper Christine E. , Bateman Philip W. , Heyde Mieke 
Published: October 2023

Abstract
Objective
Roller swabbing of surfaces is an effective way to obtain environmental DNA, but the current DNA extraction method for these samples is equipment heavy, time consuming, and increases potential contamination through multiple handling. Here, we used rollers to swab a dog kennel and compared three DNA extraction approaches (water filtration, roller trimming and direct buffer) using two different platforms (Qiacube, Kingfisher). DNA extraction methods were evaluated based on cost, effort, DNA concentration and PCR result.
Results
The roller trim method emerged as the optimal method with the best PCR results, DNA concentration and cost efficiency, while the buffer-based methods were the least labour intensive but produced mediocre PCR results and DNA concentrations. Additionally, the Kingfisher magnetic bead extractions generally ranked higher in all categories over the Qiacube column-based DNA extractions. Ultimately, the ideal DNA extraction method for a particular study is influenced by logistical constraints in the field such as the size of the roller, the availability of cold storage, and time constraints on the project. Our results demonstrate the strengths and weaknesses of each approach, allowing for informed decision making by researchers.
The effect of RDP on cell proliferation and apoptosis of porcine Leydig cells with hypoxia
Authors: Luo Jin-Ting , Xu Fafang , Wang Lei , Luo Xuan , Ma Yuhong , Zhang Jianbo , Huang Weihua Huang , Shang Yuejun , Wu Guofang 
Published: October 2023

Abstract
Rhodiola polysaccharides (RDP) has antioxidant effect on cells, but the underlying role of RDP in Leydig cells remains unknown. The study aimed to investigate the contribution of RDP to proliferation and apoptosis of porcine Leydig cells in hypoxia (1% O2, 4% CO2, 94% N2) and explore the mechanism.The porcine Leydig cells were divided into three groups: normal group, hypoxia group, and hypoxia+RDP group. Cell viability was measured by Cell Counting Kit-8 (CCK-8, Biosharp, China). The activities of Superoxide Dismutase(SOD), Malondialdehyde(MDA) and Glutathione Peroxidase(GSH-PX) was tested by enzyme-linked immunosorbent assay. Detection of cell cycle progression and cell apoptosis was using Flow Cytometry. The gene and protein expression levels were determined by quantitative real-time PCR and western blot assay, respectively. CCK-8 assay results showed that RDP can relieve the decrease in cell viability caused by hypoxia. The optimal treatment of porcine Leydig cells was as follows: porcine Leydig cells were cultured with 0.0125 mg/mL RDP polysaccharide in normoxia for 18 h, and then cultured in hypoxia for 18 h. Flow cytometry results showed that RDP can relieve that hypoxia induced cell cycle arrest in G1/S phase and decrease apoptosis in porcine Leydig cells. RDP exerted anti-inflammatory effects via inhibiting TNF-α and IL-6 expression and conferred anti-apoptotic effects by upregulating the Bax, CCND1, CDK4 and downregulating Bcl-2, Caspase-3,p21, p53 and pJNK expression.RDP may regulate p53 and JNK pathways to promote cell proliferation and inhibit cell apoptosis, thus effectively alleviating the adverse effects of hypoxia induction on porcine Leydig cells.