bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review of Extraction and Purification, Biological Properties, Structure–Activity Relationships and Future Prospects of Schisandrin C: A Major Active Constituent of Schisandra Chinensis
Authors: Xu Hao‐Nan , Wang Wei , Li Xin‐Zhuo , Sun Yu , Li Yu‐Ze , Deng Chong , Song Xiao‐Mei , Zhang Dong‐Dong 
Published: November 2023

AbstractSince ancient times, China has used natural medicine as the primary way to combat diseases and has a rich arsenal of natural medicines. With the progress of the times, the extraction of bioactive molecules from natural drugs has become the new development direction for natural medicines. Among the numerous natural drugs, Schisandrin C (Sch C), derived from Schisandra Chinensis (Turcz.) Baill. It has excellent potential for development and has been shown to possess various pharmacological properties, including hepatoprotective, antitumor and anti‐inflammatory activities. Based on the biological properties of hepatoprotection, scholars have explored Sch C and its synthetic products in depth; some studies have shown that pentosidine has the effect of improving the symptoms of liver fibrosis and reducing the concentration of alanine transaminase (ALT) and aspartate aminotransferase (AST) in the serum of rats, which is an essential inspiration for the development of anti‐liver fibrosis drugs. But more in vivo and ex vivo studies still need to be included. This paper focuses on Sch C′s extraction and synthesis, biological activities and drug development progress. The future application prospects of Sch C are discussed to perfect its development work further.
Synthesis, characterization, and performance assessment of a perovskite‐type nano photocatalyst for degradation of thiamethoxam
Authors: Pandey Vidya , Bansal Ajay , Toor Amrit Pal 
Published: November 2023

AbstractIt is essential to remove thiamethoxam (THMX) from surface water as it negatively impacts the ecology and neurological systems of insects. Hence, a study was conducted to degrade THMX with different compositions of LaFeO3/g‐C3N4 (LFCN) composites. Several methods, including X‐ray powder diffraction (XRD), ultraviolet–visible spectroscopy (UV–Vis), X‐ray photoelectron spectroscopy (XPS), Brunauer–Emmett–Teller (BET), and field emission scanning electron microscopy (FESEM), were applied to characterize the synthesized photocatalyst. The influence of many parameters on degradation, for example, THMX concentration, dosage of catalyst, and pH were studied experimentally. The degradation was highest under both UV‐C and sunlight for the synthesized catalyst, 1% LaFeO3/g‐C3N4 (LFCN1), in comparison to graphitic carbon nitride (g‐CN), and bare lanthanum ferrite (LF). The degradation was around 95% for LFCN1 under UV‐C light having an intensity of 15 W/m2 whereas degradation was 71.8% with LFCN1 photocatalyst under sunlight at neutral pH in 120 min of reaction time. The increased activity of LFCN1 was attributable to an improved surface area and a lower band gap. The study of reaction kinetics indicated second‐order behaviour. Additionally, a probable mechanism for degradation was put forth.
Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy
Authors: Ma Jiaying , Li Yongzhen , Ying Yunfei , Wu Baibei , Liu Yanmei , Zhou Juan , Hu Lidan 
Published: November 2023

AbstractFor unique surface plasmon absorption and fluorescence characteristics, gold nanorods have been developed and widely employed in the biomedical field. However, limitations still exist due their low specific surface area, instability and tendency agglomerate in cytoplasm. Mesoporous silica materials have been broadly applied in field of catalysts, adsorbents, nanoreactors, and drug carriers due to its unique mesoporous structure, highly comparative surface area, good stability and biocompatibility. Therefore, coating gold nanorods with a dendritic mesopore channels can effectively prevent particle agglomeration, while increasing the specific surface area and drug loading efficiency. This review discusses the advancements of GNR@MSN in synthetic process, bio‐imaging technique and tumor therapy. Additionally, the further application of GNR@MSN in imaging‐guided treatment modalities is explored, while its promising superior application prospect is highlighted. Finally, the issues related to in vivo studies are critically examined for facilitating the transition of this promising nanoplatform into clinical trials.
The association between telemedicine, advance care planning, and unplanned hospitalizations among high‐risk patients with cancer
Authors: Bange Erin M. , Li Yimei , Kumar Pallavi , Doucette Abigail , Gabriel Peter , Parikh Ravi , Li Eric H. , Mamtani Ronac , Getz Kelly D. 
Published: November 2023

AbstractBackgroundDespite the widespread implementation of telemedicine, there are limited data regarding its impact on key components of care for patients with incurable or high‐risk cancer. For these patients, high‐quality care requires detailed conversations regarding treatment priorities (advance care planning) and clinical care to minimize unnecessary acute care (unplanned hospitalizations). Whether telemedicine affects these outcomes relative to in‐person clinic visits was examined among patients with cancer at high risk for 6‐month mortality.MethodsThis retrospective cohort study included adult patients with cancer with any tumor type treated at the University of Pennsylvania who were newly identified between April 1 and December 31, 2020, to be at high risk for 6‐month mortality via a validated machine learning algorithm. Separate modified Poisson regressions were used to assess the occurrence of advance care planning and unplanned hospitalizations for telemedicine as compared to in‐person visits. Additional analyses were done comparing telemedicine type (video or phone) as compared to in‐person clinic visits.ResultsThe occurrence of advance care planning was similar between telemedicine and in‐person visits (6.8% vs. 6.0%; adjusted risk ratio [aRR], 1.25; 95% CI, 0.92–1.69). In regard to telemedicine subtype, patients exposed to video encounters were modestly more likely to have documented advance care planning in comparison to those seen in person (7.5% vs. 6.0%; aRR, 1.48; 95% CI, 1.03–2.11). The 3‐month risk for unplanned hospitalization was comparable for telemedicine compared to in‐person clinic encounters (21% vs. 18%; aRR, 1.06; 95% CI, 0.81–1.38).ConclusionsIn this study, care delivered by telemedicine, compared to in‐person clinic visits, produced comparable rates of advance care planning conversations without increasing hospitalizations, which suggests that vulnerable patients can be managed safely by telemedicine.
Dual‐Coating of Fluorinated Polydimethylsiloxane/Fluorinated SiO2 Nanoparticles for Superhydrophobic and High‐Efficiency Bacteriostatic Surface
Authors: Lu Shao‐Chen , Chien Hsiu‐Wen , Yu Shih‐Hsien , Chen Wei‐Cheng , Chen Hsiu‐Hui 
Published: November 2023

AbstractA simple two‐step spray method is used to prepare superhydrophobic and bacteriostatic surfaces, involving dual‐coating with polydimethylsiloxane‐normal‐fluorine (PDMS‐NF) or branched‐fluorine (PDMS‐BF) in combination with fluorinated silica nanoparticles (FSiO2‐NPs) using a spray technique. This approach has the potential to create surfaces with both water‐repellent and antimicrobial properties, which could be useful in a variety of applications. It is noteworthy that the dual‐coating on cotton fabric exhibited an impressive dual‐scale roughness and achieved superhydrophobicity with a water contact angle of 158° and a hysteresis of less than 3°. Additionally, the coating was subjected to an ultra‐high concentration of bacteria (109 CFU/mL) and was still able to inhibit more than 80 % of attachment, demonstrating its effectiveness as a bacteriostatic surface.
Reactions of Ethynyloxy Radical with Hydroperoxyl Radical: Bridging Theoretical Reaction Dynamics and Chemical Modeling of Combustion
Authors: Guo Junjiang , Tan Ningxin , Chen Lijun , Tang Shiyun , Tang Anjiang 
Published: November 2023

AbstractA detailed and accurate combustion reaction mechanism is crucial for understanding the nature of fuel combustion. In this work, a theoretical study of reaction HCCO+HO2 using M06‐2X/6‐311++G(d,p) for geometry optimization and combined methods based on spin‐unrestricted CCSD(T)/CBS level of theory with basis set extrapolation from MP2/aug‐cc‐pVnZ (n=T and Q) for energy calculations were performed. The temperature‐ and pressure‐dependent rate coefficients at 300–2000 K and 0.01–100 atm, suitable for combustion conditions, were derived using the Rice–Ramsberger–Kassel–Marcus/Master–Equation approach. Furthermore, temperature‐dependent thermochemistry data of key species for the HCCO+HO2 system has also been studied. Finally, an updated ketene model is developed by supplementing the most recent theoretical work and the theoretical work in this paper. This updated model was tested to simulate the speciation of ketene oxidation in available experimental research. It is shown that the updated model for predicting ketene oxidation exhibits a high level of agreement with experimental data across a wide range of species profiles. An analysis was conducted to identify the crucial reactions that influence ketene ignition. This paper‘s research findings are essential for enhancing the combustion mechanism of ketene and other hydrocarbons and oxygenated hydrocarbon fuels.
Aniline and Indoline Donors Based Far‐Red Active Unsymmetrical Squaraine Dyes for Dye Sensitized Solar Cells
Authors: Jadhav Avinash P. , Singh Ambarish Kumar , Maibam Ashakiran , Krishnamurty Sailaja , Krishnamoorthy Kothandam , Nithyanandhan Jayaraj 
Published: November 2023

AbstractIn dye‐sensitized solar cells (DSSC), controlling the dye‐aggregation on the metal‐oxide surface by appending the alkyl groups around the donor or π‐spacer unit of the dye is a potential approach to enhance DSSC efficiency. Further, rigidification of the dye structures by cyclization modulates the photophysical properties of the sensitizer. Here a series of donor‐acceptor‐donor (D‐A‐D) type far‐red active unsymmetrical squaraine dyes (SQA) have been designed and synthesized, where N,N‐dimethylaniline, methylated‐ and branched‐indoline have been used as donor units. These dyes showed absorption between 629–654 nm (λmax) with the molar extinction coefficient of 1.49–1.94×105 M−1 cm−1. Systematic enhancements in DSSC device efficiency have been observed due to the cyclization and alkyl‐groups incorporation in this set of dyes which were further enhanced with the addition of chenodeoxycholic acid (CDCA). The highest DSSC device efficiency of 4.78 % (Jsc of 8.77 mA/cm2 and Voc of 692 mV) has been achieved for SQA3. The IPCE profile of SQA dyes indicates the contribution of aggregated structures for the photocurrent generation. Further, co‐sensitization of SQA3 dye with a complementary visible light active dye AK4 showed the enhanced device efficiency of 6.27 % with panchromatic IPCE response.
Generation and characterization of Chd7‐iCreERT2‐tdTomato mice
Authors: Han Zi'ang , Wang Ze , Huang Zhuxi , Feng Weijun 
Published: November 2023

SummaryHeterozygous mutation of CHD7 gene causes a severe developmental disorder called CHARGE syndrome. In order to further explore the expression and function of Chd7 in vivo, we generated a Chd7‐P2A‐iCreERT2‐P2A‐tdTomato (in short, Chd7‐CT‐tdT) knockin mouse line using the CRISPR/Cas9 technology. The specificity and efficiency of two knockin genetic elements were validated. The Chd7‐CT‐tdT reporter gene could accurately reflect both the dynamic expression pattern of endogenous Chd7 during neurodevelopment and cell‐type specific expression in the brain and eye. The recombination efficiency of Chd7‐CT‐tdT in postnatal cerebellum is very high. Moreover, lineage tracing experiment showed that Chd7 is expressed in intestinal stem cells. In summary, the newly constructed Chd7‐CT‐tdT mouse line provide a useful tool to study the function of Chd7.
Phenotypic plasticity of a generalist fish species resident to lotic environments: Insights from the Great Lakes region
Authors: Hetzel Claire , Forsythe Patrick 
Published: November 2023

AbstractFish morphology is incredibly plastic and local/resident morphology can be influenced by factors including habitat, predation, resource availability, and water velocity. Through analysis of body shape using geometric morphometrics, we describe the degree of phenotypic plasticity within a generalist fish species resident to low‐order tributaries of Green Bay and Lake Michigan. We predicted that isolated populations of creek chub (Semotilus atromaculatus) would display plastic responses in body shape due to differences in selective pressures imposed by stream environments. We show that body shape of creek chub was significantly different between streams which are considered to be isolated populations, and while we expected body shape variation to remain constant between study years, we found that shape was not fixed and changed over time in the same manner among focal streams. The diversity of creek chub diet and degree of agricultural land use in the watershed were significant predictors of body morphology. The effect of resource availability and land use within the watershed demonstrates how selective pressures influence phenotypes at the population level. Our study provides insight into morphological changes of stream fish populations, which may be important in the context of changing ecosystems and novel conditions.
Impact of vasodilators on diuretic response in patients with congestive heart failure: A mechanistic trial of cimlanod (BMS‐986231)
Authors: Pellicori Pierpaolo , Cleland John G.F. , Borentain Maria , Taubel Jorg , Graham Fraser J. , Khan Javed , Bruzzese Dario , Kessler Paul , McMurray John J.V. , Voors Adriaan A. , O'Connor Christopher M. , Teerlink John R. , Felker G. Michael 
Published: November 2023

AimTo investigate the effects of Cimlanod, a nitroxyl donor with vasodilator properties, on water and salt excretion after an administration of an intravenos bolus of furosemide.Methods and resultsIn this randomized, double‐blind, mechanistic, crossover trial, 21 patients with left ventricular ejection fraction <45%, increased plasma concentrations of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) and receiving loop diuretics were given, on separate study days, either an 8 h intravenous (IV) infusion of cimlanod (12 μg/kg/min) or placebo. Furosemide was given as a 40 mg IV bolus four hours after the start of infusion. The primary endpoint was urine volume in the 4 h after the bolus of furosemide during infusion of cimlanod compared with placebo. Median NT‐proBNP at baseline was 1487 (interquartile range: 847–2665) ng/L. Infusion of cimlanod increased cardiac output and reduced blood pressure without affecting cardiac power index consistent with its vasodilator effects. Urine volume in the 4 h post‐furosemide was lower with cimlanod (1032 ± 393 ml) versus placebo (1481 ± 560 ml) (p = 0.002), as were total sodium excretion (p = 0.004), fractional sodium excretion (p = 0.016), systolic blood pressure (p < 0.001), estimated glomerular filtration rate (p = 0.012), and haemoglobin (p = 0.010), an index of plasma volume expansion.ConclusionsFor patients with heart failure and congestion, vasodilatation with agents such as cimlanod reduces the response to diuretic agents, which may offset any benefit from acute reductions in cardiac preload and afterload.
Honey Bees and Associated Matrices as Biomonitors of Soil Trace Elements: Assessment of their Sensitivity in a Regional Rural Environment
Authors: Praus Lukáš , Urbanová Sára , Száková Jiřina 
Published: November 2023

Abstract
Honey bees (Apis mellifera L.) represent a random biosampler integrating pollutants over space and time. An effective biomonitor for trace element (TE) pollution should provide a linear response to TE levels in the environment. However, uncertainties in detecting TEs originating in soil limit their use. To address this, nine experimental sites with multiple apiaries were established in the Upper Palatine Forest, Czech Republic. The soils surrounding the hives were characterized by estimations of the pseudototal and (bio)available pools of TEs. Our study aimed to (1) quantify the linear relationships between soil TE indices and TE contents in bees, bee bread, honey, and wax, and (2) verify the biobarrier function protecting honey from TE contamination. Lead (0.046–0.140 µg g−1) and nickel (0.12–4.30 µg g−1) contents in bees showed strong linear correlations with (bio)available Pb (0.012–0.254 µg g−1) and pseudototal Ni (17.1–36.4 µg g−1) in soil (Pearson's r = 0.95 and 0.88, p &lt; 0.005), providing high spatial resolution. A weaker, insignificant correlation was observed for chromium (Cr; r = 0.65) and vanadium (V; 0.44), while no correlation was found for cadmium (Cd). However, the lack of associations for Cr, V, and Cd may result from the low soil TE levels in the region, negligible differences among the majority of sites, and temporal concerns related to different time scales of the biomonitors, impacting the linear model's sensitivity. Biochemical traits in bees, such as the biobarrier function, and different bioavailability of TEs from ingested matter may affect the matrix-to-matrix transfer of TEs in an element-dependent manner. Consequently, the linear response of bee-related biomonitors to TE levels in the environment may significantly deteriorate. Environ Toxicol Chem 2024;43:288–298. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Development of curcumin‐loaded nanoemulsion stabilized with texturized whey protein concentrate: Characterization, stability and in vitro digestibility
Authors: Jafari Morteza , Parastouei Karim , Abbaszadeh Sepideh 
Published: November 2023

AbstractThe impacts of pH (2.8, 4.5, and 7.2) and extrusion cooking temperature (60°C, 85°C, and 110°C) on properties of native whey protein concentrate (NWPC) were evaluated, followed by delivering of curcumin through a nanoemulsion system stabilized with extruded WPC (EWPC). Protein solubility, surface hydrophobicity, and emulsion properties such as emulsion activity index (at 1% [w/w] protein concentration), stability index (at 0.5%, 1%, 2%, and 4% [w/w] protein concentration) and creaming index (evaluated at different protein concentrations [0.5%, 1%, 2%, and 4% w/w] and oil levels [20%, 40%, 60%, and 80%]) were improved as a function of the extrusion process. It was found that both covalent and non‐covalent interactions contributed to the stabilization of the extrudates. The rheological investigation of the emulsions stabilized with EWPC (at different oil levels [20%, 40%, 60%, and 80%]) revealed high viscosity and shear thinning behavior as well as much higher G′ and G″ values. Encapsulation efficiency was increased from 90.8% to 95.7% when NWPC and EWPC were used, respectively. The curcumin‐loaded nanoemulsion containing EWPC presented high stability in confronting with ionic strength (NaCl salt with a concentration of 0.1–1 M), pH (3, 5, and 7), thermal treatments (pasteurization at 63°C for 30 min and sterilization at 95°C for 10 min) and storage time (1 month at 4°C and 25°C). In vitro release behavior revealed that samples stabilized with EWPC showed burst release in simulated intestine conditions. However, it was more stable in stomach conditions.
Endoscopic endonasal transpterygoid nasopharyngectomy: Anatomical considerations and technical note
Authors: Liu Jianfeng , Zhao Jianhui , Wang Yibei , Zhao Yu , Han Jun , Yang Dazhang 
Published: November 2023

AbstractBackgroundThe study was designed to identify new landmarks in the parapharyngeal segment of the internal carotid artery (ICA) for nasopharyngectomy and describe a surgical procedure of endoscopic endonasal transpterygoid nasopharyngectomy (EETPN).MethodsFour cadaveric specimens were injected with colored silicone and subjected to CT scanning before dissection. The nasopharyngeal skull base was exposed using the endoscopic endonasal transpterygoid approach. The clinical data of four patients with nasopharyngeal malignances who underwent EETPN were reviewed.ResultsThe lateral edge of the longus capitis muscle medially; the foramen lacerum, petrous apex spine and the stump of the levator veli palatini muscle superior laterally; and the upper parapharyngeal ICA laterally constitute the ICA‐longus capitis muscle‐petrous apex spine triangle which was a novel landmark for the upper parapharyngeal segment of the ICA.ConclusionThe ICA‐longus capitis muscle‐petrous apex spine triangle are important landmarks of the upper parapharyngeal segment of the ICA.
Laparoscopic total pelvic exenteration combined with transanal total mesorectal excision for locally advanced prostate cancer with rectal infiltration
Authors: Ogasawara Ryo Andy , Okubo Naoya , Nakanishi Yasukazu , Imasato Naoki , Hirose Kohei , Kataoka Madoka , Yajima Shugo , Ikeda Koji , Ito Masaaki , Masuda Hitoshi 
Published: November 2023

IntroductionIntensive treatment is typically considered for very high‐risk patients with locally advanced prostate cancer and an expected survival time of 5 years or longer. Herein, we report a case of locally advanced prostate cancer with rectal infiltration treated with laparoscopic total pelvic exenteration combined with transanal total mesorectal excision.Case presentationA 73‐year‐old man presented with a ring‐shaped mass around the rectum. He was diagnosed with prostate cancer with rectal infiltration and underwent laparoscopic total pelvic exenteration combined with transanal total mesorectal excision following neoadjuvant androgen deprivation therapy. Twenty‐two months postoperatively during ongoing androgen deprivation therapy, no biochemical recurrence was observed.ConclusionTo our knowledge, this is the first report of a laparoscopic total pelvic exenteration combined with transanal total mesorectal excision for prostate cancer with rectal infiltration. We believe this surgery may be considered a new option for high‐risk prostate cancer patients with rectal infiltration.