bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing nursing services for orthopaedic trauma patients: A holistic approach through the SERVQUAL and Kano models
Authors: Cao Meijie , Peng Yuqi , Han Meiling , Liu Hualin , Xie Lunfang 
Published: February 2024

Abstract
Background: Providing high-quality service has become the core content of hospital brand building. Nursing managers increasingly focus on improving the quality of patient-centred nursing services.
Methods: Through a literature review and expert discussion, an evaluation questionnaire and a Kano model questionnaire were developed to assess the quality of nursing services for orthopaedic trauma inpatients. An expectation questionnaire was distributed on the day of admission to the emergency department or orthopaedic outpatient department. The perception questionnaire and Kano model questionnaire were distributed at discharge. The SERVQUAL model was used to identify low-level nursing service elements, and the Kano model, factor selection line and sensitivity analysis were used to determine the rectification order.
Results: Three hundred people completed two rounds of the survey. The total score for nursing service quality was -0.55. The 26 items assessing nursing service quality included 21 low-level items. Among them, there were 1 must-be attribute, 5 attractive attributes, 12 one-dimensional attributes, and 3 indifferent attributes. There were 10 items identified for improvement among the 21 low-level items.
Conclusions: The main reason for low nursing service quality is the inability to ensure the safety and comfort of patients. Constructing a training system for orthopaedic nurses and promoting multidisciplinary and departmental cooperation are the primary strategies for optimizing the quality of nursing services for orthopaedic trauma inpatients.
Trial registration: This study was an observational study and no interventions were performed on the patients, so there was no trial registration.
Body positive social media posts: who likes them anyway? The role of internalization and body dissatisfaction in the implicit and explicit bias towards thin-ideal social media posts
Authors: Buvár Ágnes , Schein Adél , Tódor Imre , Varga Attila , Koronczai Beatrix , Szőcs Levente Álmos , Nagy Bence , Stankovics Adél , Ágoston-Kostyál Csilla 
Published: February 2024

Abstract

Background
Research has repeatedly shown that body positivity is positively related to body satisfaction and that body positive social media posts can foster body acceptance. However, the question arises whether individuals, especially those with low body dissatisfaction, prefer body positive social media posts over thin-ideal posts. In this paper, we aim to explore the role of body ideal internalization, trait body dissatisfaction and actual body weight in the implicit and explicit biases towards thin-ideal social media posts.
Methods
We conducted two online questionnaires with implicit attitude tests. In Study 1, we obtained data from 140 women (Mage = 31.2, SDage = 13.8), while overall 533 women (adolescent sample (N = 218): aged 14–18, young adult sample (N = 315): aged 19–29) participated in Study 2. The data were analyzed using hierarchical regression models to examine the associations between BMI, body ideal internalization, trait body dissatisfaction and implicit and explicit biases towards thin-ideal social media posts.
Results
Internalization was associated with the explicit bias towards thin-ideal social media posts only in the adolescent sample (Study 2). The negative appreciation of body size was negatively associated with the implicit and explicit biases towards thin-ideal social media posts in Study 1 and in the young adult sample of Study 2. In the young adult sample (Study 2), our results indicated that a higher BMI predicted positive explicit bias towards body positive posts, while the effect was trending in the case of implicit bias.
Conclusion
These findings confirm the validity of sociocultural theory on the adolescent sample and the validity of social identity theory and perceived similarity on the (young) adult sample in the context of implicit and explicit biases towards thin-ideal social media posts. The body positivity movement reaches its target population in (young) adulthood: body positive posts are appreciated by those with body image issues. Our results contribute to understanding the receptiveness to the messages of body positive social media posts.
Synthesis, characterization, and nitrate removal study of nano γ-alumina and magnetite-alumina nanocomposite adsorbents prepared by various methods and precursors
Authors: Khatamian Maasoumeh , Derakhshan Saeedeh Khadivi , Nami Shamin Hosseini , Fazli-Shokouhi Sara 
Published: February 2024

Abstract
This study delves into the synthesis of differen nano-sized γ-alumina (γA1-5) employing diverse precursors and methods, including nepheline syenite, lime, aluminum hydroxide, precipitation, and hydrothermal processes at varying reaction times. Simultaneously, magnetite (Fe3O4) nanoparticles and magnetite/γ-alumina nanocomposites (Fn/γA5) were synthesized using the co-precipitation method with varying weight ratios (n). Our primary objective was to optimize γ-alumina synthesis by comparing multiple methods, shedding light on the influence of different precursors and sources. Hence, a comprehensive adsorption study was conducted to assess the materials’ efficacy in nitrate removal. This study fills gaps in the literature, providing a novel perspective through the simultaneous assessment of magnetite/alumina nanocomposites and pure alumina performance. Structural and morphological properties were studied employing XRD, FT-IR, FESEM, EDX, XRD, and VSM techniques. The conducted experiments for γA5, F5/γA5, and F10/γA5 nanocomposites showcased the optimum pH of 5 and contact time of 45 min for all samples. The influence of nitrate’s initial concentration on the removal percentage was investigated with initial concentrations of 10 ppm, 50 ppm, and 100 ppm. γA5, F5/γA5 and F10/γA5 nanocomposites had 17.3%, 55%, and 70% at 10 ppm, 18%, 55.16%, and 74% at 50 ppm, and 8.6%, 53.1%, and 63%, respectively. The results highlighted that F10/γA5 can be used as a remarkable adsorbent for wastewater treatment purposes.
A Unified SVPWM Fault Tolerant Control Algorithm for Single Leg Fault Reconstruction Topology of Two-level Inverter
Authors: Cai Zhiduan , Xu Lihao 
Published: February 2024

Abstract
To improve the reliability of Two-level three phase voltage source inverters, a uniform fault tolerant strategy based on space vector pulse width modulation is proposed for different leg faults. The reconstructed topologies of inverters with different bridge arm faults are different, which makes the basic voltage vector phase of each reconstructed topology inconsistent, resulting in different calculations. Therefore, the coordinate transformation is applied to place the basic voltage vectors of each reconstructed topology on the synchronous stationary αβ coordinate system so that the calculations of the reconstructed topology under different bridge arm faults are unified, thus reducing the complexity of fault-tolerant control. Aiming at the three-phase current asymmetry caused by the neutral point voltage oscillation in inverter topology reconstruction, a transient compensation method of neutral point voltage offset for the α-axis component of the reference voltage vector is introduced to suppress the adverse effects. The compensation method directly offers a neutral point voltage offset value after Clarke transformation and corrects the α-axis component of the reference voltage vector, avoiding the integral calculation in the conventional voltage compensation algorithm. The correctness and effectiveness of the proposed fault-tolerant control strategy are verified experimentally.
Exploring the interplay between antiretroviral therapy and the gut-oral microbiome axis in people living with HIV
Authors: Narayanan Aswathy , Kieri Oscar , Vesterbacka Jan , Manoharan Lokeshwaran , Chen Puran , Ghorbani Mahin , Ljunggren Hans-Gustaf , Chen Margaret Sällberg , Aleman Soo , Sönnerborg Anders , Ray Shilpa , Nowak Piotr 
Published: February 2024

Abstract

Background: The gut and oral microbiome is altered in people living with HIV (PLWH). While antiretroviral treatment (ART) is pivotal in restoring immune function in PLWH, several studies have identified an association between specific antiretrovirals, particularly integrase inhibitors (INSTI), and weight gain. In our study, we have explored the differences in the oral and gut microbiota of PLWH under different ART regimens, and its correlation to Body Mass Index (BMI).
Methods: Fecal and salivary samples were collected from PLWH (n=69) and healthy controls (HC, n=80). DNA was extracted for 16S rRNA sequencing on the MiSeq platform. The obtained raw reads were pre-processed, and taxonomy analysis was performed to determine the microbial composition. Additionally, linear discriminant analysis effect size and correlation analyses were used to identify differences in abundant taxa and relationship between microbial abundance and ART regimens, BMI, CD4+T-cell count, CD4/CD8 ratio, and duration of ART.
Results: We found that the PLWH had significantly lower richness compared to HC in both the oral and gut environment. Interestingly, the gut microbiome composition of INSTI-treated individuals was enriched with Faecalibacterium and Bifidobacterium, whereas non-nucleotide reverse transcriptase inhibitor (NNRTI) treated individuals were enriched with Gordonibacter, Megasphaera, and Staphylococcus. In the oral microenvironment, Veillonella was significantly more abundant in INSTI-treated individuals and Fusobacterium and Alloprevotella in the NNRTI-treated individuals. Furthermore, Bifidobacterium and Dorea were enriched in gut milieu of PLWH with high BMI.
Conclusion: Our study revealed significant shifts in bacterial diversity and composition between HC and PLWH in both the oral and gut environments. Additionally, we also detected specific microbial signatures, which were correlated with different treatment regimens and BMI among the PLWH under successful ART.
cgeniepy: A Python package for analysing cGENIE Earth System Model output
Authors: Ying Rui 
Published: February 2024

Abstract

The cGENIE model is an numerical model that simulates the various components of the Earth system (e.g., atmosphere, ocean, land, biosphere, ice sheet) and their interactions. It has been widely used in studying and reconstructing the past ocean and climate states. Here, I provide a Python package cgeniepy for reading, analysing, and visualising the cGENIE model output, and performing the model-data comparison. The package is designed to facilitate the post-simulation analysis for all cGENIE users. The package is designed as object-oriented, thus many features are standalone and can be used without cGENIE background.
Inhibitory Activity of Chemical Constituents from Vitellaria paradoxa Gaertn. (Sapotaceae) Against Pathogens Associated with Respiratory Tract Infections
Authors: Ojo Olusesan , Mmutlane Edwin M. , Ndinteh Derek T. 
Published: February 2024

Abstract

Vitellaria paradoxa Gaertn. is a commonly used medicinal plant for the treatment of tuberculosis (TB) and other respiratory infections in Africa. Therefore, its phytochemicals can be explored in rational drug discovery, development, and design against respiratory-tract infections. The aim of this study is to identify chemical composition of V. paradoxa hexane stem-bark extract, and further isolate possible antimicrobial agents from its crude extract. 48 phytochemicals, including1-heptacosanol, 2-nonenal, (E)-, and hexadecanoic acid, methyl ester were identified using GC-MS. Column chromatography led to the isolation of three compounds, including 11-hydroxy β-amyrin cinnamate (1), α-amyrin cinnamate (2), and sitosterol cinnamate (3). All the compounds showed activity against all the tested pathogens, with compound (3) showed better activity against all bacterial strains, with minimum inhibitory concentrations (MICs) varying from 0.0625 to 0.25 mg/ml. Compounds (1) and (2) showed no cytotoxicity against the cervical cancer cell line (HeLa) (IC50; 82.53 ± 4.07 and 77.82 ± 10.5 respectively). To our knowledge, compounds 2 and 3 are reported here from the stem-bark part of the plant for the first time. Similarly, inhibitory activities of compounds 1–3 against the tested strains are studied here for the first time. These results provide in part scientific justification for the traditional uses of V. paradoxa for treating respiratory tract infections, including tuberculosis in Africa.
A robust optimisation genetic algorithm for HDR prostate brachytherapy including all major uncertainties II: Algorithm evaluation on 49 patients
Authors: Kennedy Andrew C. , Douglass Michael J. J. , Gowda Raghu , Santos Alexandre M. C. 
Published: February 2024

Abstract
Introduction: Treatment plans in high-dose-rate (HDR) prostate brachytherapy (BT) are currently optimised to meet clinical objectives in the nominal plan; however, uncertainties cause the scenario delivered to deviate from this plan and may fail objectives. A robust optimiser generates plans that maximise the probability of dose-volume-histogram (DVH) metrics passing in the delivered scenario.Method: A probabilistic robust optimiser was evaluated on 49 patients. Three objective functions were maximised to obtain the Pareto front consisting of 200 robust-optimised treatment plans. Each objective function approximated the robustness of three DVH metrics: (1) the minimum dose to the hottest 90% of the prostate, \({\text{D}}_{90}^{\text{P}}\), the maximum doses to the (2) urethra, \({\text{D}}_{0.01 \text{c}\text{c}}^{\text{U}}\), and (3) rectum, \({\text{D}}_{0.1 \text{c}\text{c}}^{\text{R}}\). Pareto front plans were robustly evaluated using 1000 probabilistic uncertainty scenarios, outputting the pass-rates for \({\text{D}}_{90}^{\text{P}}\), \({\text{D}}_{0.01 \text{c}\text{c}}^{\text{U}}\), \({\text{D}}_{0.1 \text{c}\text{c}}^{\text{R}}\), and all three simultaneously, the overall pass-rate. The best robust-optimised plan was selected from the Pareto front and compared to the TPS-optimised plan for ten patients by a radiation oncologist, then 49 patient robust-optimised plans were compared.Results: All robust-optimised plans had higher overall pass-rates (mean: 50.7 ± 1.5%, SD: 14.2%) compared to the TPS-optimised plans (mean: 32.0 ± 1.5%, SD: 12.3%). This was also the case with the \({\text{D}}_{0.01 \text{c}\text{c}}^{\text{U}}\) pass-rates with the robust-optimised plans having a mean of 66.0 ± 1.3% (SD: 12.1) compared with 47.2 ± 1.3% (SD: 9.3%). The pass-rates for \({\text{D}}_{90}^{\text{P}}\) were higher for the robust-optimised plans (mean: 85.6 ± 1.1%, SD: 9.5%) in 36 patients, the TPS-optimised mean was 82.2 ± 1.1% (SD: 13.8%). Twenty-seven patients had higher \({\text{D}}_{0.1 \text{c}\text{c}}^{\text{R}}\) pass-rates in the robust-optimised plans with a mean of 94.54 ± 0.56% (SD: 7.35%) compared with 93.71 ± 0.56% (SD: 6.73%).Conclusion: A robust optimisation algorithm generated treatment plans with higher robustness than the TPS-optimised plans for nine out of ten patients, evaluated by a radiation oncologist, in an average time of 1-minute-49-seconds.
In silico structural modeling of the N-terminal domain of ampullate spidroin from the cellar spider, Crossopriza lyoni
Authors: Mohtar Johan Ariff , Shahimin Mohd Faidz Mohamad , Bakar Amirul Ridzuan Abu , Rahman Khadijah Hanim Abdul 
Published: February 2024

Abstract
Spider dragline silk, or major ampullate silk, is a remarkably high-performing polymeric biomaterial with outstanding physical and mechanical properties due to its silk proteins, called spidroins. In particular, the N-terminus of spidroins plays a crucial role in silk fibre formation. Extensive research on the 3D N-terminal structure of major ampullate spidroins (MaSps) in orbicularian spiders has led to the neglect of major ampullate silks from non-orbicularians, despite their unique silk protein sequence, with a predominant focus on the adult stage rather than the early developmental stage. In this study, we elucidated the N-terminal ampullate spidroin (NT-AmSp) structure from the prenymph of the non-orbicularian species, Crossopriza lyoni. The NT-AmSp sequence of 155 amino acids was subjected to protein homology modeling, threading, and ab initio modeling through multiserver-based in silico predictions using SWISS-MODEL, Phyre2, and I-TASSER, respectively. The quality of each generated model was analysed using ProSA-web, QMEAN, and SAVES (parameters i.e., ERRAT, Verify3D, and Ramachandran plot) servers. Finally, the models were superimposed with an NMR-determined NT-MaSp from E. australisfor similarity assessment using SuperPose. Models ranked first by both SWISS-MODEL and Phyre2 (Model 1) and Model 3 from I-TASSER with the highest C-score were chosen as the best predicted models. All models possessed five α-helices except for Model 3 with an additional α-helical conformation representing the signal peptide region. Overall, the models were of relatively good quality according to the analysis. The structure superimposition with E. australisNT-MaSp1 (4FBS) yielded an acceptable RMSD value between 2.0 Å and 3.0 Å. In silico structural modeling proves to be a powerful tool for assessing protein molecular functions.
Significance: The elucidation of the N-terminal structure of AmSp from C. lyoniprenymph may contribute to enhancing our understanding of the structural and functional diversity in the N-terminal domain of spidroins across spider taxa between the adult and early nymphal stage and can be used in the development as soluble tag for heterologous protein expression.
Effectiveness of Manual Therapy for Patients with Low Back Pain from the Perspective of Physical and Psychosocial Factors
Authors: Nakagawa Hotaka , Okubo Yu , Hattori Hiroshi , Hamada Yuji , Kikuchi Yuto , Mizoguchi Yasuaki , Akasaka Kiyokazu 
Published: February 2024

Abstract
Purpose: The purpose of this study was to determine the effectiveness of the Arthrokinematic Approach (AKA)-Hakata method for patients with low back pain (LBP).
Methods: The subjects were 39 patients with LBP who visited a medical facility between June 1, 2022 and November 30, 2022. The intervention period was 8 weeks with 5 treatment sessions, and patient assessments were performed using the patient self-reported majors of LBP and motor function assessment.
Results: The AKA-Hakata method showed significant differences in all items evaluated in the longitudinal comparison of patients. In addition, an interaction was observed only in the Roland-Morris Disability Questionnaire between the two groups classified using the Subgrouping for Targeted Treatment Back Screening Tool.
Conclusions: The results of this study show that treatment with the AKA-Hakata method may have an early therapeutic effect on physical and psychosocial risks in daily life. The results of this study indicate that the AKA-Hakata method is effective in the treatment of LBP. However, this study evaluated a relatively short treatment period of five sessions and did not examine long-term treatment effects. Further research is needed to optimize the treatment duration in detail and to investigate the effectiveness of the AKA-Hakata method.
Fatty Liver Index as a Predictor of Metabolic Syndrome in Adult Females in India
Authors: M Yogesh , Vamja Roshni , Vala Vijay , Nagda Jay 
Published: February 2024

Abstract
Background: Metabolic associated fatty liver disease (MAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Fatty liver index (FLI) is a validated model to detect MAFLD. This study aimed to evaluate the accuracy of FLI in predicting MetS in adult females in India.
Methods: This cross-sectional study included 450 adult females attending a tertiary care hospital in India. Clinical examination, anthropometric measurements, and biochemical tests were conducted. FLI was calculated using the standard formula. Mets were diagnosed using harmonized criteria. Logistic regression analysis was performed to determine predictors.
Results: The mean age was 44.2±7.8 years and the prevalence of MetS was 61%. Increasing the FLI category was significantly associated with a worsening metabolic profile. The odds of hypertension, diabetes, MetS, and cardiovascular disease progressively increased with higher FLI levels (p<0.001), denoting a dose-response relationship. FLI demonstrated good diagnostic accuracy for MetS with AUC 0.86 (95% CI 0.81–0.89). It showed significantly higher predictive ability compared to individual components like waist circumference and lipids. A FLI cutoff ≥30 provided an optimal balance of sensitivity (71%) and specificity (59%) for predicting MetS.
Conclusion: FLI demonstrates a strong association with MetS and related comorbidities in a dose-dependent manner. It shows good diagnostic accuracy for predicting MetS, better than individual criteria. FLI can be a simple, low-cost screening tool to identify high metabolic risk individuals in resource-limited settings.
Novel Perspectives of TSLP and RXR Signaling in Corticosteroid-Resistant Asthma: Updates on TSLP Blockers
Authors: Zhang Song , Dsouza Karen , Beeraka Narasimha M , Liu Junqi , Reshetniak Oksana , PR Hemanth Vikram , Priyanka LG , Greeshma M.V. , Bhupalam Pradeep Kumar , PA Mahesh , Manogaran Prasath , Deka Rajashree , Bannimath Gurupadayya , Sinelnikov Mikhail Y , Nikolenko Vladimir N. , Bulygin Kirill , Fan Ruitai 
Published: February 2024

Abstract:
Previous studies described that asthma patients who received corticosteroid
therapy have been constrained by the corticosteroid resistance subsequently fostered to
severe refractory asthma. In this review, we discussed the implications of TSLP, RXR,
the role of STAT5-activating cytokines, and IL-33/NH-cell signaling pathways, and recent
clinical evidence on TSLP blockers in steroid-resistant asthma. We have searched
several public databases such as Pubmed, Scopus, and Relemed and obtained information
pertinent to the TSLP, RXR, TSLP blockers, the STAT5-activating cytokines, and
IL-33. We discussed the multiple cell signaling mechanisms underlying steroid resistance.
Blocking the TSLP and other key signaling molecules like STAT5 can retrieve
the sensitivity of natural helper-cells to corticosteroids. RXR derivatives treatment can
modulate the activity of TSLP, which further modulates steroid resistance in severe asthmatic
patients and in patients with refractory asthma. We discussed the steroid-resistance
mediated by the Th2 cells and Th2-driven eosinophilia upon corticosteroid intake.
Thus, this review will be beneficial for clinicians and molecular biologists to explore the
inflammatory pathways associated with refractory asthma conditions and develop novel
therapies against corticosteroid-resistant asthma.