bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of maternal COVID‐19 on cardiac functions: From fetal life to infancy
Authors: Şahan Yasemin Özdemir , Sakcak Bedri , Göncü Ayhan Şule , Tanaçan Atakan , Kibar Gül Ayşe Esin , Şahin Dilek , İlker Çetin İbrahim 
Published: January 2024

AbstractObjectiveTo evaluate both short and mid‐term effects of maternal COVID‐19 on cardiac functions of fetuses and children.MethodsThe present case‐control study was conducted on 36 pregnant women who had COVID‐19 infection in the second trimester of pregnancy and 30 pregnant women as healthy controls. Fetal, neonatal, and infant cardiac functions were compared between the groups. Assessment of fetal cardiac functions were performed in the last trimester of the pregnancy at least 6 weeks after the recovery of infection. The first postnatal echo was performed within the first 2 weeks and the follow‐up (second) echo was performed in the 6–8 weeks of life.ResultsThe demographic data were similar between groups. Interventricular septum and left ventricular posterior wall end‐diastolic dimensions were significantly higher in the study group in both fetal, neonatal, and infant periods. Impaired diastolic functions of right and left ventricles were detected and myocardial performance indexes with tissue doppler imaging of both lateral walls and septum were significantly higher than controls at all periods.ConclusionMaternal COVID‐19 seems to have a global impact on the cardiac functions of babies in the short and mid‐term periods after maternal recovery.
Left atrial strain, embolic stroke of undetermined source, and atrial fibrillation detection
Authors: Bashir Zubair , Chen Edward W. , Wang Shuyuan , Shu Liqi , Goldstein Eric D. , Rana Maheen , Kala Narendra , Dai Xing , Mandel Daniel , Has Phinnara , Xie Mingxing , Wang Tao , Dickey John B , Poppas Athena , Simmons James , Song Christopher , Yaghi Shadi , Haines Philip 
Published: January 2024

AbstractBackgroundAtrial cardiopathy is a proposed mechanism of embolic stroke of undetermined source (ESUS). Left atrial (LA) strain may identify early atrial cardiopathy prior to structural changes. We aim to study the associations between LA strain, ESUS, and atrial fibrillation (AF) detection in ESUS.MethodsThe study population included patients with ESUS and noncardioembolic (NCE) stroke presenting to the Rhode Island Hospital Stroke Center between January 2016 and June 2017 who underwent transthoracic echocardiography. Speckle tracking echocardiography (STE) was used to measure the three phases of LA strain (reservoir, conduit, and contractile). Binary logistic regression analysis was performed to determine the associations between LA strain and stroke subtype (ESUS vs. NCE) as well as follow‐up detection of AF in ESUS patients.ResultsWe identified 656 patients, 307 with ESUS and 349 with NCE. In binary logistic regression, the lowest tertiles of LA reservoir (adjusted OR 1.944, 95% CI 1.266–2.986, p = .002), contractile (aOR 1.568, 95% CI 1.035–2.374, p = .034), and conduit strain (aOR 2.288, 95% CI 1.448–3.613, p = .001) were more likely to be significantly associated with ESUS compared to NCE stroke. Among all ESUS patients, the lowest tertiles of LA reservoir strain (OR 2.534, 95% CI 1.029–6.236, p = .043), contractile strain (OR 2.828, 95% CI 1.158–6.903, p = .022), and conduit strain (OR 2.614, 95% CI 1.003–6.815, p = .049) were significantly associated with subsequent detection of AF.ConclusionReduced LA strain is associated with ESUS occurrence and AF detection in ESUS patients. Therefore, quantification of LA strain in ESUS patients may improve risk stratification and guide secondary prevention strategies.
Use of transillumination echocardiography in the assessment and diagnosis of bicuspid aortic valve
Authors: Martinez‐Dominguez Pavel , Luna‐Alcala Santiago , Guerra Enrique C. , Espinola‐Zavaleta Nilda 
Published: January 2024

AbstractBicuspid aortic valve is the most common congenital heart defect. Transthoracic echocardiogram is the initial tool to assess and diagnose this condition, however, transesophageal echocardiogram with 3D modalities, including transillumination have a better anatomical and functional evaluation of the valve, allowing to classify the bicuspid aortic valve according to the position of the raphe and assess the main vessels for complications or exclude other cardiovascular diseases.
The association between the basal metabolic rate and cardiovascular disease: A two‐sample Mendelian randomization study
Authors: Chen Kaijie , Zhang Yue , Zhou Siyu , Jin Chengjiang , Xiang Meixiang , Ma Hong 
Published: January 2024

AbstractBackgroundMendelian randomization analysis was applied to elucidate the causal relationship between the basal metabolic rate (BMR) and common cardiovascular diseases.MethodWe choose BMR as exposure. BMR is the metabolic rate of the body when the basic physiological activities (blood circulation, breathing and constant body temperature) are maintained. The normal BMR is 1507 kcal/day for men and 1276 kcal/day for women. The dataset was drawn from the public GWAS dataset (GWAS ID: ukb‐a‐268), collected and analysed by UK biobank, containing 331,307 European males and females. SNPs independently and strongly associated with BMR were used as instrumental variables in the inverse variance weighted analysis. MR‐Egger, weighted median, MR pleiotropy residual sum, and outlier methods were also performed, and the sensitivity was evaluated using horizontal pleiotropy and heterogeneity analyses to ensure the stability of the results.ResultsAn increased BMR is associated with a higher risk of cardiomyopathy (odds ratio [OR] = 2.00, 95% confidence interval [CI], 1.57–2.54, p = 1.87 × 10−8), heart failure (OR = 1.39, 95% CI, 1.27–2.51, p = 8.1 × 10−13), and valvular heart disease (OR = 1.18, 95% CI, 1.10–1.27, p = .00001). However, there was no clear association between BMR and the subtypes of other cardiovascular diseases, such as coronary disease (OR = .96, 95% CI, .85–1.08, p = .48651) and atrial fibrillation (AF) (OR = 1.85, 95% CI, 1.70–2.02, p = 6.28 × 10−44).ConclusionOur study reveals a possible causal effect of BMR on the risk of cardiomyopathy, heart failure and valvular disease, but not for coronary disease and AF.
Effect of statins on sepsis and inflammatory factors: A Mendelian randomization study
Authors: Zhang Kai , Liu Wei , Liang Hongjin 
Published: January 2024

AbstractBackgroundAs inhibitors of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR), statins can reduce the synthesis of low‐density lipoptrotein cholesterol (LDL‐C), and are clinically used as first‐line lipid‐lowering drugs to prevent cardiovascular diseases. However, the effect of statins on sepsis is controversial. Therefore, we intend to explore the effects of statins on sepsis and inflammatory factors through Mendelian randomization (MR).MethodWe obtained sepsis, inflammatory factors, and LDL‐C data from open and free genome‐wide association study (GWAS) for subsequent analysis. Inverse‐variance weighted (IVW) was the main method, MR‐Egger, MR‐PRESSO and Cochrane's Q‐test were used as sensitive analysis to evaluate the robustness of MR results.ResultsStatins were associated with a reduced risk of sepsis under 75 (sepsis in individuals under 75 years old) (OR: .716, 95% CI: .572–.896, p = .003), elevated circulating IL‐18 (OR: .762, 95% CI: .643–.903, p = .002) and elevated circulating CCL2 (OR: .416, 95% CI: .279–.620, p = 1.685e−5).ConclusionStatins may have a protective effect on sepsis and this may provide a new idea for the treatment of sepsis.
Gender and justice: The status of women in Ottoman courts
Authors: Coşgel Metin M. , Genç Hamdi , Özer Emre , Yıldırım Sadullah 
Published: January 2024

AbstractThis paper studies legal disparities between men and women in a patriarchal framework. Throughout history, women have confronted discrimination in matters of inheritance, property ownership, and various other legal rights. We examine the consequences of legal discrimination for women's differential engagement and success within legal conflicts, using data from Ottoman courts in the early nineteenth century. The results show that women were parties to approximately 30 per cent of cases, with a modest gender gap of around eight to ten percentage points in terms of plaintiff win rates. The gap varied across courts and types of cases, consistent with gender disparities in legal knowledge and trial stakes in patriarchal societies. Notably, when litigating against male defendants, the disparity was more pronounced in provincial courts (Konya and Kütahya), as opposed to courts in the capital city (Galata and Üsküdar). Similarly, while the gender gap was greater in property and probate cases than those involving personal crimes and commercial exchange, the gap was reversed in family matters. The analysis suggests that a significant portion of the gender gap in litigation success can be attributed to disparities in evidence presentation (witness testimonies, written documents and legal opinions).
In vitro differentiation of human amniotic epithelial stem cells into keratinocytes regulated by OPN3
Authors: Jin Shuqi , Zhang Wei , Zeng Wen , Zhang Yulei , Feng Jianglong , Wang Yu , Luo Huanhuan , Liu Ting , Lu Hongguang 
Published: January 2024

AbstractHuman amniotic epithelial stem cells (hAESCs) are regarded as potential alternatives to keratinocytes (KCs) used for skin wound healing. Light is an alternative approach for inducing stem cell differentiation. Opsins (OPNs), a family of light‐sensitive, G protein‐coupled receptors, play a multitude of light‐dependent and light‐independent functions in extraocular tissues. However, it remains unclear whether the light sensitivity and function of OPNs are involved in light‐induced differentiation of hAESCs to KCs. Herein, we determine the role of OPNs in differentiation of hAESCs into KCs through cell and molecular biology approaches in vitro. It is shown that mRNA expression of OPN3 in the amniotic membrane and hAESCs was higher than the other four primary OPNs by RT‐qPCR analysis. Changes in OPN3 gene expression had a significant impact on cell proliferation, stemness and differentiation capability of hAESCs. Furthermore, we found a significant upregulation of OPN3, KRT5 and KRT14 with hAESCs treated at 3 × 33 J/cm2 irradiation from blue‐light LED. Taken together, these results suggest that OPN3 acts as a positive regulator of differentiation of hAESCs into KCs. This study provides a novel insight into photosensitive OPNs associated with photobiomodulation(PBM)‐induced differentiation in stem cells.
Functional composition outweighs taxonomic and functional diversity in maintaining ecosystem properties and processes of mangrove forests
Authors: Rahman Md Mizanur , Zimmer Martin , Donato Daniel , Ahmed Imran , Xu Ming , Wu Jin 
Published: January 2024

AbstractBiodiversity loss can have significant consequences for human well‐being, as it can affect multiple ecosystem properties and processes (MEPP) that drive ecosystem services. However, a comprehensive understanding of the link between environmental factors, biodiversity, and MEPP remains elusive, especially in mangrove ecosystems that millions of people along tropical coastlines worldwide depend upon. Here, we collated a comprehensive dataset on forest inventory, plant traits, and environmental factors across 93 plots in the Sundarbans Reserved Forests, Bangladesh. The functional composition (FC) of leaf area showed a stronger positive association with MEPP, being determined by total biomass and productivity of the mangroves, sediment organic carbon, and ammonium, phosphorus, and potassium contents of the sediment, than species richness (SR) or functional diversity (FD). Further, FC mediated a strong negative association of sediment salinity, and a positive association of SR, with MEPP. The similar but opposite total associations of SR and sediment salinity with MEPP suggest that species‐rich mangroves could offset the negative impacts of rising salinity on MEPP. When focusing on a single aspect of MEPP, both FD and FC mattered, with the FD of leaf area showing a strong association with mangrove productivity and sediment potassium content, while the FC of leaf litter nitrogen showed the strongest associations with sediment ammonium and phosphorus contents. Therefore, to sustain mangrove ecosystems as a reliable nature‐based solution for climate change mitigation, conservation and (re‐)establishment projects should prioritize regionally dominant species with high leaf area and nitrogen content, plus functionally different species to support the ecosystem processes and services provided by mangroves.
Lipidomic analysis of facial skin surface lipids in acne in young women
Authors: Su Qianqian , Hu Xueqing , Yang Manli , He Huaming , Jia Yan 
Published: January 2024

AbstractBackgroundAlterations in the secretion and composition of skin surface lipids (SSL) are closely associated with the development of acne. Lipidomics is a useful tool to analyse the SSL of different types of acne. Our previous study found that phosphatidylserine and triacylglycerols dominate SSL changes in male acne and infantile acne, respectively. However, skin surface lipids as well as specific lipids in female acne patients remain to be investigated.ObjectivesTo analyse and compare the SSL profile of acne women and healthy women and to discuss the involvement of differential lipids in acne development.MethodsSystematic lipidomics approach (high‐throughput UPLC‐QTOF‐MS technology in combination with multivariate data analysis methods) was used to analyse the variations of SSL between acne and healthy groups.ResultsAnalysis revealed significant differences in lipid content and composition between the two groups. Further analysis showed that levels of 13 individual lipids were significantly different and followed the same trend as the main class and subclasses. The largest individual contributor to the subgroup was triglycerides (TG) and phosphatidylinositol (PI). In addition, female acne patients exhibited reduced ceramide chain length (CCL) and increased levels of unsaturated fatty acids (UFAs), The changes of CCL in female acne are identical to male acne.ConclusionsThere was a significantly higher level of TG and PI in the SSL of female acne patients. A reduction in CCL and an increase in UFAs content might contribute to the reduced skin barrier function in acne patients. The results suggest that female acne may have different pathogenesis than male acne.
Cosmetic application of the stem‐bark extract of Bertholletia excelsa H.B.K
Authors: Silva Márcia J. A. , Acho Leonard D. R. , Carneiro Simone B. , Guimarães Anderson C. , Lima Emerson S. 
Published: January 2024

AbstractObjectiveThe Amazon has a rich biodiversity where many different plant species can be found. This diversity is an important source of bioactive substances, mainly due to the different structural components of their phytometabolites. Research for natural products is a strategy for the development of new agents in therapeutic applications, especially cosmetic applications, that have better pharmacological potential. Within this perspective, the objective of the study was to investigate the cosmetic application (anti‐aging potential) of the stem‐bark extract of Bertholletia excelsa H.B.K – (SBEBE), popularly known as the Brazil nut tree, here called SBEBE, a noble plant species of the Amazon that is rich in selenium.MethodsEnzymatic, glycation, proliferation, cell‐healing, collagen quantification, toxicity and genotoxicity assays were used.ResultsAmong the enzymes involved in the extracellular matrix of the skin, SBEBE was able to inhibit only elastase (62.67 ± 3.75) when compared to the standard sivelestat (89.04 ± 0.53), and the extract was also able to inhibit both the oxidative and the non‐oxidative pathway. When cell toxicity in fibroblasts (MRC‐5) and keratinocytes (HACAT) was evaluated, SBEBE did not present toxicity in 24 h of incubation. After this period, the extract showed average cytotoxicity in 48 and 72 h, but not enough to reach the concentration of 50% of MRC‐5 fibroblasts. In the trypan blue assay, the extract promoted fibroblast proliferation in 24, 48 and 72 h of incubation, which was evaluated through exponential cell growth, with emphasis mainly on the lowest concentration with results higher than the standard. When the cell healing capacity was evaluated, in 48 h of exposure to fibroblast, SBEBE was able to induce a cell carpet (cell film) in the cell monolayer scratch assay.ConclusionsSBEBE stimulated collagen production at all concentrations tested. In the alkaline comet assay, at the lowest concentration, the extract did not induce DNA damage when compared to the reference drug doxorubicin. This study proved that SBEBE extract can be considered an ally in the treatment of skin anti‐ageing as a possible biotechnological, phytocosmetic product.
Perception of nurses applying silver diamine fluoride to children's teeth: A mixed methods study
Authors: Ong Yu Jie , Meyer Beau , Quek Yu Ting Eline , Wong Mun Loke , Hong Catherine Hsu Ling , Hu Shijia 
Published: January 2024

AbstractBackgroundNo studies have evaluated the unique potential of nurse‐led silver diamine fluoride (SDF) application for children to bridge the gap in interprofessional collaboration.AimTo investigate the attitudes, beliefs and perceptions of nurses regarding nurse‐led SDF application at the well‐child visit and identify possible barriers and make recommendations.DesignMixed methods design involving a questionnaire and semi‐structured individual interviews were conducted.ResultsAll eligible nurses (n = 110) completed the questionnaire, and 16 were interviewed. Questionnaire responses highlighted that nurses were not confident in providing oral health services (score: <3 of 5) beyond oral hygiene advice (score: ≥3.9 of 5) but believed that they should be providing these services for individuals with difficulty accessing care. Interviews reflected that most nurses viewed oral health care as an important part of paediatric health but were limited by knowledge, time and manpower. Most were willing to expand their job scope to include SDF application with formal education and training, competency assessments and approaches to counter time limitations.ConclusionWhere nurses are already providing basic oral healthcare, nurse‐led SDF application could be the next step. Findings suggest that systemic changes should include strategies to empower and motivate nurses to apply SDF at the well‐child visit.
RETRACTED: Effects of evidence‐based nursing on surgical site wound infections in patients undergoing surgery for liver cancer: A meta‐analysis
Authors: Shi Yong‐Hong , Wang Qing‐Ju , Huang Li‐Zhen , Li Na , Ren Xin‐Ting , Bi Shu‐Min 
Published: January 2024

AbstractThis study aimed to systematically evaluate the impact of evidence‐based nursing (EBN) on perioperative wound infections and postoperative complications in patients undergoing surgery for liver hepatocellular carcinoma (LIHC). Randomised controlled trials (RCTs) on the application of EBN on patients receiving LIHC surgery were searched in PubMed, Web of Science, Cochrane Library, Embase, Wanfang, China Biomedical Literature Database and China National Knowledge Infrastructure from the inception of each database to September 2023. Studies were screened and evaluated by two investigators based on inclusion and exclusion criteria, and data were extracted from the final included literature. RevMan 4.0 was used for data analysis. Overall, 15 RCTs involving 1374 patients with LIHC were included, with 687 in the EBN group and 687 in the conventional care group. The analysis revealed that the incidence of wound infections (odds ratio [OR] = 0.32, 95% confidence interval [CI]: 0.18–0.56, p < 0.001) and postoperative complications (OR = 0.22, 95% CI: 0.15–0.31, p < 0.001) was significantly lower in the EBN group than in the conventional care group. The available evidence suggests that nursing strategies for EBN applied in the perioperative period in patients with LIHC receiving surgery can effectively reduce the incidence of wound infections and postoperative complications and promote postoperative recovery.
Response to heat stress and glutenins allelic variation effects on quality traits in durum wheat
Authors: Tabbita Facundo , Ammar Karim , Ibba María Itria , Andrade Francisco , Maccaferri Marco , Sanguineti Maria Corinna , Tuberosa Roberto , Guzmán Carlos 
Published: January 2024

AbstractIn the context of climate change, high temperature is one of the main abiotic stresses hampering durum wheat production. Through the characterization of an international panel of 271 genotypes, this study investigates the effects of heat stress on quality traits and identifies which glutenins (Glu‐1, Glu‐2 and Glu‐3 loci) alleles are the most important to obtain high gluten strength under optimal and high temperature conditions. In parallel with the wide variability observed in the panel, the genotype and environmental effects, including their interaction, showed highly significant effect on test weight, thousand kernel weight, grain protein content (GPC), sodium dodecyl sulphate sedimentation volume (SDSS) and SDSS index. Only one genotype maintained test weight and thousand kernel weight under heat‐stress conditions whereas for GPC, SDSS and SDSS index, most genotypes increased values. All Glu loci had significant effects on grain protein content (with the exception of Glu‐B2), SDSS and SDSS Index. None of the Glu loci interacted with the environment or years under study. Among the identified alleles, Glu‐A1b, Glu‐B1an, Glu‐B1a, Glu‐B2a, Glu‐A3a.x, Glu‐A3d, Glu‐B3a and Glu‐B3ax (including the LMW‐2 pattern) were associated with high values for SDSS and SDSS Index. Genotypes identified in this study, with good performances under optimal and high temperature growing conditions, could be useful for breeding programs. The non‐interaction of the Glu loci with the environment facilitates the introgression of desired alleles regardless of high growing temperatures.
Redistribution of dopants between amorphous and crystalline phases in ZrO2–SiO2 nanoceramics
Authors: Fu Le , Yu Wenjun , Wang Bohan , Deng Ying 
Published: January 2024

AbstractExtensive efforts have been devoted to investigate the distribution of dopants in ceramics. However, one critical question remained barely explored, which is the redistribution of dopants between amorphous and crystalline phases during fast sintering of ceramics. Here we address this gap by observing the redistribution of five selected dopants (Y, Ce, Yb, Hf, and Ta) in ZrO2–SiO2 nanoceramics during sintering. We designed two groups of experiments: In group one, dual‐phase amorphous particles were sintered with multicomponent crystalline ones. The former particles were ZrO2–SiO2 glass, whereas the latter ones consisted of ZrO2 solid‐solution nanocrystallites (SSNCs) embedded in an oxide glass containing Zr, Si, Y, Ce, Hf, Yb, and Ta. In group two, dual‐phase crystalline particles were sintered with multicomponent amorphous ones. The former particles were composed of ZrO2 nanocrystallites (NCs) embedded in an amorphous SiO2 matrix, whereas the latter ones were oxide glass containing Zr, Si, Y, Ce, Hf, Yb, and Ta. Redistribution of the dopants from the glass to ZrO2 NCs occurred in the two groups, that is, the five dopants migrated from the glass matrix into the ZrO2 NCs, forming ZrO2 SSNCs. The redistribution of the dopants not only increased the configuration entropy of the ZrO2 NCs but also benefited the network structure integrity of SiO2 glass. The dopant redistribution process was driven by the minimization of the studied material's free energy. The reported results are important for understanding the redistribution behaviors of dopants and are expected to provide new insights to design new ceramics via the multielement co‐doping strategy.