bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating shared risk variants and genetic etiology between Alzheimer’s disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis
Authors: Dang Weijia , Hao Tianqi , Li Ning , Zhang Hualin , Li Ziqi , Yu Hongmei , Wen Yalu , Zheng Deqiang , Liu Long 
Published: February 2025

IntroductionObservational studies have reported that patients with Alzheimer’s disease (AD) have a greater burden of comorbidities typically associated with stress-related psychiatric disorders. However, the contribution of hereditary factors to this comorbidity remains unclear. We evaluated phenotypic associations using observational data from the UK Biobank.MethodOur study focused on investigating the shared risk variants and genetic etiology underlying AD and three stress-related psychiatric disorders: post-traumatic stress disorder, anxiety disorder, and major depressive disorder. By leveraging summary statistics from genome-wide association studies, we investigated global genetic correlations using linkage disequilibrium score regression, genetic covariance analysis, and high-definition likelihood. Genome-wide cross-trait analysis with association analysis based on subsets and cross-phenotype association were performed to discover genome-wide significant risk variants shared between AD and the three stress-related psychiatric disorders.ResultsA significant positive genetic correlation was observed between AD and major depressive disorder using linkage disequilibrium score regression (rg = 0.231; P = 0.018), genetic covariance analysis (rg = 0.138; P &lt; 0.001), and high-definition likelihood (rg = 0.188; P &lt; 0.001). Association analysis based on subsets and cross-phenotype association revealed thirteen risk variants in six genes shared between AD and post-traumatic stress disorder; seven risk variants in four genes shared between AD and anxiety disorder; and 23 risk variants in four genes shared between AD and major depressive disorder. Functional annotation and gene-set enrichment analysis indicated that 12 genes for comorbidity shared between patients with AD and all three stress-related psychiatric disorders were enriched in the spleen, pancreas, and whole blood.ConclusionThese results advance our knowledge of the shared genetic origins of comorbidities and pave the way for advancements in the diagnosis, management, and prevention of stress-related AD.
Associations of substance use and positive coping behaviors with sleep quality during the COVID-19 pandemic
Authors: Laudie Jessica , Stangl Bethany L. , Gunawan Tommy , Schwandt Melanie L. , Cheng Cecilia , Gilmore Amanda K. , Goldman David , Ramchandani Vijay A. , Diazgranados Nancy , Luk Jeremy W. 
Published: February 2025

BackgroundThe COVID-19 pandemic may have negatively impacted individuals' sleep quality. In this study, we examined changes in sleep quality from before to during the COVID-19 pandemic by history of alcohol use disorder (AUD) and investigated the cross-sectional associations of substance use and positive coping behaviors with sleep quality domains.MethodsData were drawn from the NIAAA COVID-19 Pandemic Impact on Alcohol Study which enrolled participants from June 2020 to December 2022. Participants (N = 373, 50.9% male, mean age = 43.7, 37.3% with AUD history) reported their sleep quality using the Pittsburgh Sleep Quality Index (PSQI) for the month prior to the pandemic and the past month before the time of assessment. Multilevel modeling and linear regression analyses were conducted.ResultsIndividuals with AUD history reported worse overall sleep quality than those without AUD history both before and during the pandemic. Individuals without AUD history reported an overall increase in PSQI scores (worsened sleep quality) across time. AUD history and substance use behaviors due to the pandemic were associated with worse sleep quality. Conversely, positive coping behaviors (e.g., take care of body, make time to relax, connect with others, multiple healthy behaviors) were associated with better sleep quality domains.ConclusionsAUD history, substance use, and positive coping behaviors were correlated with sleep quality during the pandemic. These findings may offer insight into behavioral targets to improve sleep quality in the context of significant stress exposure and can help improve preparedness for future public health crises.
Preliminary ultrasonography study of the pancreas in the dromedary camel (Camelus dromedarius)
Authors: Lakhel El Hassania , El Allali Khalid , Achaâban Mohamed Rachid , Azrib Rahma 
Published: February 2025

IntroductionPancreatic lesions in camels can lead to significant economic losses. They are practically undetectable, as clinical signs alone are insufficient for specific diagnosis. Ultrasonography is a valuable diagnostic tool for evaluating the pancreas. However, ultrasonographic reference patterns of the pancreas in the camel are yet to be established. This study aimed to define the ultrasonographic appearance, reference values, location, and acoustic window for evaluating the pancreas in healthy camels.MethodsEight adult and 14 young Moroccan camels were investigated by ultrasonography using a micro-convex probe with SIUI CTS-900 V and Samsung MH70A Doppler ultrasound scanners at 3.5 MHz.ResultsThe body of the pancreas was scanned just below the right kidney, behind the 12th rib; an ultrasonographic pattern of pancreatic parenchyma appeared as a hyperechoic elongated band, including the portal vein, with a Doppler flow response. The average thickness of the body was 3.60 ± 0.24 cm (n = 14) in young camels significantly lower than in adult camels 4.61 ± 0.26 cm (n = 8). The right lobe was scanned on the right side, adjacent to the duodenal ampulla and abomasum, beneath the liver along the 11th, 10th, and 9th intercostal spaces. The ultrasonographic pattern of parenchyma appeared as a hyperechoic triangle compared to the liver, including portal and duodenal-pancreatic veins, showing a Doppler flow response. The corresponding parenchyma thickness within the three intercostal spaces was 3.93 ± 0.33 cm, 4.40 ± 0.20 cm, and 3.46 ± 0.39 cm in the young camels (n = 14), and 4.99 ± 0.46 cm, 5.90 ± 0.27 cm, and 4.11 ± 0.68 cm in the adults (n = 8), respectively. The pancreatic major duct was seen as an anechoic circle with a hyperechoic wall, with a maximum diameter of 1 cm, and the left lobe scanned beneath the cranial extremity of the spleen; its ultrasonographic pattern showed an irregular hypoechoic band with a mean thickness of 2.32 ± 0.32 cm (n = 14) in young camels and 3.08 ± 0.52 cm (n = 8) in the adults, including a small splenic vein.ConclusionUltrasonography combined with Doppler techniques provides valuable information on pancreatic health, blood flow, and tissue perfusion, aiding early detection of pancreatic diseases and, consequently, minimizing economic losses in camel husbandry.
Phaseolus acutifolius Recombinant Lectin Exerts Differential Proapoptotic Activity on EGFR+ and EGFR− Colon Cancer Cells and Provokes T Cell-Assisted Antitumor Responses in Mice
Authors: Luján-Méndez Francisco , García-López Patricia , Berumen Laura C. , García-Alcocer Guadalupe , Ferriz-Martínez Roberto , Ramírez-Carrera Anette , González-Barrón Jaqueline , García-Gasca Teresa 
Published: February 2025

Background: rTBL-1, a recombinant lectin from Phaseolus acutifolius, exhibit proapoptotic activity on colon cancer cells and inhibitory properties on colon tumorigenesis in vivo. Apoptosis has been associated with a phospho-EGFR/phospho-p38/phospho-p53 mechanistic axis. Immunogenicity data have been observed in treated animals, but its possible involvement in the antitumor response remained unexplored. Objective: We investigated whether the cytotoxic activity of rTBL-1 depends on EGFR and its capacity to produce antitumor responses on syngeneic colon cancer in mice, with and without T cells, in order to explore its possible involvement in the process. Results:rTBL-1 exhibited cytotoxic effects in a concentration-dependent manner in both EGFR+ (MC-38) and EGFR− (CT-26) colon cancer cells with LC50 values of 23.50 and 30.01 µg/mL, respectively (p = 0.063). Apoptotic effects were slower and longer-lasting in MC-38 than in CT-26 cells. Significant increases in caspase-3 proteolytic activation and PARP1 cleavage were detected in both cell types, despite PARP1 rheostasis in CT-26 cells. Intralesional treatment with rTBL-1 inhibited the growth of established tumors in immunocompetent BALB/c mice in 27.81% (p = 0.0008) with a benefit in survival (p = 0.022), but not in immunodeficient BALB/c nude mice. Conclusions:rTBL-1 induces apoptosis in colon cancer cells by EGFR independent mechanisms, although its presence could be related to deeper responses. Unresponsiveness in nude mice indicated that rTBL-1 antitumor effect is the synergistic result of apoptosis induction and T cell-mediated cytotoxicity in the tumor. Future studies will focus on the immunogenic effects triggered by the antitumor activity of rTBL-1 in colon cancer.
Optimal Design of Interior Permanent Magnet Synchronous Motor Considering Various Sources of Uncertainty
Authors: Guidotti Giacomo , Barri Dario , Soresini Federico , Gobbi Massimiliano 
Published: February 2025

The automotive industry is experiencing a period of transition from traditional internal combustion engine (ICE) vehicles to electric vehicles. Although electric machines have always been used in many applications, they are generally designed neglecting the sources of uncertainty, even such uncertainty can lead to significant deterioration of the motor performance. The aim of this paper is to compare the results obtained from the multi-objective optimization of an interior permanent magnet synchronous motor (IPMSM) using a robust approach versus a deterministic one. Unlike other studies in the literature, this research simultaneously considers different sources of uncertainty, such as geometric parameters, magnet properties, and operating temperature, to assess the variability of electric motor performance. Different designs of a 48 slot–8 pole motor are simulated with finite element analysis, then the outputs are used to train artificial neural networks that are employed to find the optimal design with different approaches. The method incorporates an innovative use of the neural network-based variance estimation (NNVE) technique to efficiently calculate the standard deviation of the objective functions. Finally, the results of the robust optimization are compared with those of the deterministic optimization. Due to the small margin of improvement in robustness, both methods lead to similar results.
О возможности использования дополнительного навесного оборудования для подачи воды на передней части пожарного автомобиля
Authors: Курносов М.Н. , Авилов М.М. , Нукеев Ж.Н. , Кунанков С.Б. 
Published: February 2025

В статье рассматривается внедрение дополнительного оборудования для подачи воды, размещенного на передней части пожарного автомобиля, способствующее повышению эффективности борьбы с пожарами на открытых территориях. Проведенный анализ подтверждает техническую возможность интеграции данного оборудования в существующие пожарные машины без значительных изменений конструкции. Предложенное решение расширяет возможности пожарного автомобиля, например, становится доступность подачи огнетушащих веществ на ходу, что может быть полезно при маневрировании и тушении природных пожаров.
The article discusses the implementation of additional water supply equipment located on the front of a fire truck, which helps to increase the effectiveness of firefighting in open areas. The analysis confirms the technical feasibility of integrating this equipment into existing fire trucks without significant design changes. The proposed solution expands the capabilities of the fire truck, for example, it becomes possible to supply fire extinguishing agents on the move, which can be useful when maneuvering and extinguishing wildfires.
Критический анализ работоспособности гидроэлеваторных систем, применяемых для забора воды пожарной техникой
Authors: Куртов С.О. , Малый В.П. , Макаров В.М. 
Published: February 2025

Профессорско-преподавательский состав Сибирской пожарно-спасательной академии ГПС МЧС России продолжает исследования в области организации бесперебойной подачи огнетушащих веществ на месте тушения пожара и при ликвидации последствий чрезвычайных ситуаций. В настоящей статье подвергнута критическому анализу действующая методика расчета работоспособности гидроэлеваторной системы, применяемой для забора воды пожарными насосами в случае, когда «классический» вариант (с использованием всасывающей линии) не эффективен. Установлено, что при напоре за гидроэлеватором 17 м (с учетом указанной производительности 600 л/мин) рассмотренная авторами схема является неработоспособной (даже без учета гидравлического сопротивления напорно-всасывающего рукава, используемого в конце напорной рукавной линии).
The teaching staff of the Siberian Fire and Rescue Academy of the State Fire and Rescue Service of the Ministry of Emergency Situations of Russia continues research in the field of organization of uninterrupted supply of fire extinguishing agents at the scene of fire extinguishing and during the elimination of emergency situations. In this article critically analyzed the current method of calculating the performance of the hydro-elevator system used for water intake by fire pumps in the case where the “classical” version (using the suction line) is not effective. It is established that at a head behind the hydraulic elevator 17 m (taking into account the specified capacity of 600 l/min), the scheme considered by the authors is inoperable (even without taking into account the hydraulic resistance of the pressure-suction hose used at the end of the pressure hose line).
Исследование существующих подходов государственного регулирования системы профилактики в области пожарной безопасности в условиях цифровизации
Authors: Яловка А.А. 
Published: February 2025

Данная статья посвящена исследованию существующих подходов к государственному регулированию в области профилактики пожаров в условиях цифровизации. В работе проведен анализ нормативно-правовой базы, регулирующей пожарную безопасность, а также рассмотрены современные цифровые инструменты и технологии, применяемые для повышения эффективности профилактических мероприятий.
This article is devoted to the study of existing approaches to state regulation in the field of fire prevention in the conditions of digitalization in the field of fire prevention in the conditions of digitalization. The paper analyzes the regulatory and legal framework governing fire safety, as well as considers modern digital tools and technologies used to improve the effectiveness of preventive measures.
Волонтерская деятельность обучающихся СПСА ГПС МЧС России с молодежными группами риска Арктической зоны
Authors: Зинченко Т.В. 
Published: February 2025

В статье рассматривается проблема употребления психоактивных веществ среди молодежи; необходимость профилактики употребления психоактивных веществ среди молодежи; волонтерская деятельность обучающихся Сибирская пожарно-спасательная академия ГПС МЧС России с группами риска Арктической зоны посредством вовлечения в социально-значимую деятельность и обучения основам первой помощи.
The article addresses the issue of substance use among youth; the need for substance use prevention among young people; volunteer activities of The Siberian Fire and Rescue Academy of EMERCOM of Russia students with risk groups in the Arctic zone through involvement in socially significant activities and training in the basics of first aid.
PERKEMBANGAN PSIKOLOGI ANAK DALAM PENDIDIKAN KARAKTER PESERTA DIDIK DI SEKOLAH DASAR
Authors: Damayanti Devi , Usriyah Lailatul , Mu'alimin Mu'alimin 
Published: February 2025

ABSTRACT
This research aims to identify children's psychological development in character education at MI Al Hidayah Mangli Jember class IV. The research method used is qualitative with data collection techniques through interviews, observation and documentation. The data collected is then analyzed using data collection, data presentation and data verification methods. The results of the research show that the characters of sixth grade students vary, but overall, they tend to have religious, disciplined and cooperative characters. School principals, homeroom teachers, religious teachers and parents have a positive understanding of children's psychological development in character education. Collaboration and transparent communication between educational institutions and parents play an important role in advancing children's psychological aspects through moral education. The school principal also implements the school's vision and mission to create students who have religious character, discipline, honesty and care for others. Support and motivation from both internal and external sources have a significant impact in shaping the moral character of students through education.
Keywords: Child Psychology, Character building

ABSTRAK
Penelitian ini bertujuan untuk mengidentifikasikan perkembangan psikologi anak dalam pendidikan karakter di MI Al Hidayah Mangli Jember kelas IV. Metode penelitian yang digunakan adalah kualitatif dengan teknik pengumpulan data melalui wawancara, observasi, dan dokumentasi. Data yang dikumpulkan kemudian dianalisis dengan metode pengumpulan data, penyajian data, dan verifikasi data. Hasil penelitian menunjukkan bahwa karakter siswa kelas enam bervariasi, namun secara keseluruhan, mereka cenderung memiliki karakter religius, disiplin, dan bergotong royong. Kepala sekolah, wali kelas, guru agama, dan orang tua memiliki pemahaman yang positif tentang perkembangan psikologi anak dalam pendidikan karakter. Kerjasama dan komunikasi yang transparan antara lembaga pendidikan dan wali murid memiliki peran penting dalam memajukan aspek psikologis anak melalui pendidikan moral. Kepala sekolah juga menerapkan visi dan misi sekolah untuk mewujudkan peserta didik yang memiliki karakter yang religius, disiplin, jujur, dan peduli terhadap sesama.Dukungan dan motivasi baik dari internal maupun eksternal memiliki dampak yang signifikan dalam membentuk karakter moral peserta didik melalui pendidikan.
Kata Kunci: Psikologi Anak, Pendidikan Karakter
PERAN MEDIA DIGITAL BERBASIS INFOKUS TERHADAP PEMBELAJARAN IPS DI KELAS VI SEKOLAH DASAR NEGERI 16 PADANG MAGEK
Authors: Yunita Desra , Lasari Yufi Latmini 
Published: February 2025

The aim of this research is to examine the role of Infocus-Based Digital Media in Social Sciences Learning in Class VI of Padang Magek 16 State Elementary School. This research adopted a qualitative approach method, where in-depth interviews with students were conducted after they utilized infocus media during the learning process. The results of this research are that infocus-based learning media has a significant role in helping teachers achieve learning goals. It is said that because based on research results, students are less enthusiastic about learning because they feel learning is less interesting, especially in social studies learning. This problem can be overcome by using infocus-based learning media. Class IV students at Padang 16 State Elementary School feel that learning is more enjoyable and the social studies learning delivered is easier to understand.

Tujuan penelitian ini adalah untuk meneliti tentang Peran Media Digital Berbasis Infokus Terhadap Pembelajaran Ips Di Kelas VI Sekolah Dasar Negeri 16 Padang Magek. MetPenelitian ini mengadopsi metode pendekatan kualitatif, di mana wawancara yang mendalam dengan siswa dilakukan setelah mereka memanfaatkan media infokus selama proses belajar. Hasil penelitian ini ialah media pembelajaran berbasis infokus memiliki peran yang signifikan untuk membantu guru mencapai tujuan pembelajaran. Dikatakan demikian karena berdasarkan hasil penelitian peserta didik kurang antusias untuk belajar karena merasa pembelajaran kurang menarik terutama dalam pembelajaran IPS. Problem tersebut dapat diatasi dengan adanya media pembelajaran berbasis infokus, peserta didik kelas IV Sekolah Dasar Negeri 16 Padang merasa pembelajaran terasa lebih menyenangkan dan pembelajaran IPS yang disampaikan lebih mudah dipahami.
IMPLEMENTASI MODEL PEMBELAJARAN PROJECT BASED LEARNING PADA MATA KULIAH BAHASA DAERAH MI/SD DALAM MENGEMBANGKAN KREATIVITAS MAHASISWA PGMI UIN KHAS JEMBER
Authors: Sufraini Sufraini , Fauzi Imron , Sabarudin Sabarudin 
Published: February 2025

ABSTRACTThis study aims to describe the application of project-based learning model (PjBL) in MI / SD local language courses in developing the creativity of PGMI UIN Kh. Achmad Siddiq This research focuses on the application of PjBL in developing students' creativity, especially in MI / SD regional language classes. The approach adopted is qualitative-descriptive. The research was conducted on students of 3rd semester D3 class, majoring in PGMI, who were enrolled in MI / SD Regional Language course. Data was collected through observation, interviews and documentation, and then analysed using triangulation techniques and sources to achieve data validity. The results showed that the use of PjBL encouraged students to be more creative, active and collaborative. Students are able to integrate creativity with the preservation of local culture, producing products that are educational and authentic. In addition, the project increased motivation to learn, technological skills and pride in cultural identity. This research supports the importance of using PjBL as an innovative strategy in higher education to develop 21st century skills, strengthen love for local culture, and increase the relevance of learning to practical needs.
Keywords: MI/SD local language, creativity, PGMI students, PjBL
ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan tentang penerapan model pembelajaran project based learning (PjBL) pada mata kuliah bahasa daerah MI/SD dalam mengembangkan kreativitas mahasiswa PGMI UIN Kh. Achmad Siddiq Penelitian ini berfokus pada penerapan PjBL dalam mengembangkan kreativitas mahasiswa terutama pada perkuliahan Bahasa Daerah MI/SD. Pendekatan yang digunakan adalah kualitatif-deskriptif. Penelitian dilakukan pada mahasiswa kelas D3 semester 3 jurusan PGMI yang mengikuti mata kuliah Bahasa Daerah MI/SD. Pengumpulan data dilakukan melalui observasi, wawancara, dan dokumentasi, kemudian dianalisis dengan teknik dan sumber triangulasi untuk mencapai validitas data. Hasil penelitian menunjukkan bahwa penerapan PjBL mendorong mahasiswa untuk lebih kreatif, aktif, dan kolaboratif. Mahasiswa mampu mengintegrasikan kreativitas dengan pelestarian budaya lokal, menghasilkan produk yang bernilai edukatif dan autentik. Selain itu, proyek ini meningkatkan motivasi belajar, keterampilan teknologi, serta rasa bangga terhadap identitas budaya. Penelitian ini mendukung pentingnya penggunaan PjBL sebagai strategi inovatif dalam pendidikan tinggi untuk mengembangkan keterampilan abad ke-21, memperkuat kecintaan pada budaya lokal, dan meningkatkan relevansi pembelajaran dengan kebutuhan praktis
Kata Kunci: Bahasa Daerah MI/SD, kreativitas, Mahasiswa PGMI, PjBL.
Effects of Al2O3/SiO2 double-layer mask on nanotrench etching of GaN via hydrogen environment anisotropic thermal etching (HEATE)
Authors: Sato Shuya , Takahashi Yuki , Momma Tomoaki , Kikuchi Akihiko 
Published: February 2025

Abstract
This paper proposes a double-layer Al2O3 (1 nm)/SiO2 (15 nm) mask as a new etching mask for GaN nanofabrication using the hydrogen environment anisotropic thermal etching (HEATE) method. We fabricated GaN nanotrench structures with various aperture widths and depths ranging from 1–1.9 µm using both a conventional SiO2 single-layer mask and the new double-layer mask, comparing the processing shapes in detail. With the new mask, side etching is reduced, the verticality of the etched sides improve, and the facets near the flat m-plane on the upper side of the trench enlarge. Thus, it is possible to fabricate nanotrench and mesa structures with vertical sidewalls and widths of 100–1200 nm using the double-layer mask and an AlInN etch stop layer.