bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical, Radiological, and Histopathological Characteristics of a Patient with a Pituitary Tumor of the Corticotrophinoma Type — Case Report
Authors: Krzentowska Anna , Gołkowski Filip , Czepko Ryszard 
Published: February 2024

Introduction. Cushing disease is a rare but severe endocrine disorder. It is caused by a pituitary tumor producing excessive amounts of adrenocorticotropic hormone (ACTH) which is subsequently responsible for excessive production of cortisol in the adrenal glands. Hypercortisolism manifests with many symptoms and disorders that affect numerous organs.
Aim. To increase knowledge among nursing staff about the symptoms, causes, and treatment of patients with Cushing disease.
Case Report. A 40-year-old patient with a history of infertility treatment was admitted to the Clinical Department of Neurosurgery of St. Raphael Hospital in Krakow due to a pituitary tumor. For 7 years the patient had been experiencing symptoms such as weight gain, excessive tiredness, and menstrual disorders. The MRI examination of the pituitary showed a tumor in the sella turcica with dimensions of 4.5×5.5×4.5 mm. The histopathological examination revealed corticotropic pituitary adenoma (positive for ACTH). The patient underwent surgery after which symptoms of hypercortisolism decreased and menstruation returned. The patient became pregnant and gave birth to a child.
Discussion. A proper diagnosis in this patient’s case could protect her from development of many complications related to other organs, such as diabetes mellitus or hypertension.
Conclusions. Cushing disease remains in some cases undiagnosed for many years. The patient is being referred to various specialists (ophthalmologist, gynecologist, rheumatologist) due to symptoms that are in fact complications of hypercortisolism. The case illustrates the importance of early recognition of the main symptoms of hypercortisolism. Such clinical skill would undeniably help to refer the patient to the appropriate specialist, i.e., an endocrinologist much earlier, and thus establish the correct diagnosis and implement appropriate treatment. (JNNN 2023;12(3):134–139)
Análisis bibliométrico de la literatura científica sobre el abono orgánico Bokashi: alternativa en la agricultura sostenible
Authors: González-Rodríguez Gabriela , Preciado-Rangel Pablo , Lizárraga-Bernal Christian Guadalupe , Espinosa-Palomeque Bernardo 
Published: February 2024

El uso Bokashi como enmienda orgánica del suelo y fuente de nutrición para las plantas ha recibido una atención considerable en los últimos años. El bokashi, método de compostaje de origen japonés, basado en la fermentación aeróbica de los residuos mediante la inoculación de microorganismos eficientes; que son bacterias anaeróbicas y levaduras lácticas que aceleran el proceso acortando el tiempo de obtención del abono. El objetivo de la investigación fue desarrollar un análisis bibliométrico sobre Bokashi en SCOPUS. El proceso se realizó el 10 de agosto de 2022 mediante el algoritmo de búsqueda: (TITLE-ABS-KEY (Bocashi) OR TITLE-ABS-KEY (Bokashi)) vinculado a título del artículo, resumen y palabras claves. La investigación se realizó utilizando el instrumento de investigación de los softwares VOSviewer y Harzing´s Publish of Perish. Los resultados del análisis bibliométrico registraron un total de 161 documentos publicados entre los años 1999 a 2022. Las principales tipologías de las publicaciones fue 129 artículos (80.12%) y 25 conferencias (15.52 %), el 87.58% (141 publicaciones) fueron en inglés. Brasil fue el país como más publicaciones (39), le siguió Indonesia (31) y México (22). Ventura, M. U. fue el autor con mayor productividad con seis artículos. En las redes de coautorías se encontraron dos redes principales: la primera con Fregonezi, G. A. F., Hata, F. T. y Ventura, M. U. y, la segunda, con Grądzki, Z. El interés crecimiento del Bokashi como alternativa sostenible en los sistemas de producción agrícolas debe permitir establecer y construir redes de publicaciones científicas, revisitas científicas, investigadores, organización de investigación, países y palabras claves.
TODDLER FECES MANAGEMENT AND BASIC IMMUNIZATION ON THE INCIDENCE OF DIARRHEA: A SPATIAL ANALYSIS
Authors: Rahmawati Nur Anisah , Mahmudah Mahmudah , Wibowo Arief , Indriani Diah , Rosita Dewi Erni , Firmanty Mustofa Vina 
Published: February 2024

Background: Diarrhea is one of the leading causes of child morbidity and mortality in low and middle-income countries. 23.8% prevalence of diarrhea was found among children under five years of age. Area-based management is required to address and provide specific interventions. Purpose: The study aims to analyze the effect of unsafe toddler feces management and incomplete primary immunization on the incidence of diarrhea using a spatial analysis in East Java, Indonesia. Methods: The data used is the 2018 Basic Health Research data. The measurement of the relationship between region and diarrhea was carried out by studying Moran's I index. Lisa Cluster Map and the Lisa Significance Map were also studied to understand distribution and significance. The regression used is OLS regression, spatial lag, and spatial error. The best model is assessed by comparing various parameters. Data were analyzed using GeoDA. Results: Moran's I result shows an index value of 0.489 with a pseudo-value of 0.001 (p <0.05) and a z-value of 3.7515. Lisa Cluster Map shows seven high-high category areas, five low-low category areas, and one high-low category area. Lisa's Significance Map shows six areas p=0.05, three areas p=0.01, and four areas p=0.001. The unsafe management of toddler feces and incomplete primary immunization related to diarrhea shows a significance of p<0.05. By comparing the R square, log-likelihood, p(sign), and sigma square values, the better model is the spatial lag model. Conclusion: The unsafe toddler feces management and incomplete primary immunization related to diarrhea.
PARENTAL INTERACTIONS AND CYBERBULLYING ON PSYCHOLOGICAL IMPACT OF HIGH SCHOOL ADOLESCENTS IN SUMBERSARI DISTRICT, JEMBER
Authors: Alkatiri Shalsabiila , Rukmini Devy Shrimarti , Ubaidillah Nanda Iskandar 
Published: February 2024

Background: The National Survey stated 45% of 2,777 Indonesian youths had experienced cyberbullying, including harassment via chat applications (45%), distribution of personal documentation (41%) and other harassment (14%). A preliminary study in Jember Regency stated that 21 out of 30 students had been victims of cyberbullying. Purpose: To find out the correlation between parental interaction (the role of monitoring online activity, disciplining and potential conflict) and exposure to cyberbullying (flamming, harassment, denigrations, impersonations, outing, exclusion, cyberstalking) on psychological impact (self-confidence, anxiety, hopelessness and suicidal intent) of high school youth in Sumbersari District, Jember Regency. Methods: This is a quantitative research that was conducted at 12 Senior High Schools at Sumbersari District, Jember with a total population of 5,346 students. Simple random sampling research, of 358 Lemeshow sampling students. Collecting interview data and filling out a questionnaire forJanuary 2019. Analysis of chi-square bivariate test data. Results: The significance of parental interaction was found related to conflict with the level of self-confidence and anxiety of adolescents (p 0.00; OR 2.77 and p 0.02; OR 1.71). Interestingly, it was found that harassment had an impact on the level of self-confidence (p 0.00; OR 2.29), anxiety (p 0.00; OR 1.92), hopelessness (p 0.00; ­­OR 2.91) and intention to commit suicide (p 0.02; OR 1.84). Cyberstalking had an impact on the level of self-confidence (p 0.00; OR: 3.02), anxiety (p 0.00; OR: 1.81), hopelessness (p 0.00; OR: 5.50) and intention to suicide (p 0.00; OR: 2.44). Conclusion: Parental interactions and exposure to cyberbullying have a significant effect and play an important role in the psychological impact experienced in adolescence.
DETERMINANTS OF HYPERTENSION PREVENTION BEHAVIOR IN WOMEN OF REPRODUCTIVE AGE (WRA) IN TAKERAN SUB-DISTRICT, MAGETAN REGENCY
Authors: Septiana Mia , Kusumawati Yuli 
Published: February 2024

Background: Basic health research data (Riskesdas) in 2018 shows that hypertension is one of the highest causes of death in Indonesia, reaching 6.8%. If hypertension occurs in women of childbearing age, the risk of complications, morbidity, and even death will be higher due to the risk of eclampsia during labor. Efforts to prevent hypertension in women of Reproductive age (WRA) need to be improved through increasing hypertension prevention behavior. Various factors can influence hypertension prevention behavior. Purpose: This study aims to analyze the determinants of hypertension prevention behavior in a group of women of reproductive age in Takeran District, Magetan Regency. Methods: This observational study was conducted with a cross-sectional design. The research sample was women of Reproductive age in the Takeran District, Magetan Regency, with as many as 276 people. The sampling technique used purposive sampling technique. This research was conducted in March 2022, using data analysis using the Chi-Square Test and Logistic Regression Test. The instruments used in this research were questionnaires and informed consent. Results: There was a relationship between knowledge (p = 0.02), self-efficacy (p = 0.00, family support (p = 0.00, and support from health workers (p = 0.000) with hypertension prevention behavior, but there was no relationship between age (p = 1,00) and attitude (p = 0.49) with hypertension prevention behavior. Conclusion: The strongest determinant factor for hypertension prevention behavior in the group of women of Reproductive age was self-efficacy. Good self-efficacy can influence good hypertension prevention behavior.
EFFECTIVENESS OF THE LARVACIDE ETHANOL EXTRACT OF SOURSOP (Annona muricata L.) LEAVES AGAINST Aedes aegypti LARVA
Authors: Selvi Marcellia  , Tiara Inggrit Margareta  , Agustina Retnaningsih  
Published: February 2024

Highlights

Dengue fever, caused by mosquitoes known as Aedes aegypti, can be avoided by applying larvicides while the insects are still in their larval stage.
The extract from soursop leaves at a concentration of 3% is the most effective for Aedes aegypti larvae, resulting in 100% mortality.

Abstract
Background: Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by one of the four serotypes of dengue virus transmitted through mosquitoes, especially Aedes aegypti and Aedes albopictus. As the Aedes aegypti mosquito-borne DHF illness is still in its larval stage, it can be prevented by utilizing larvicides. A more secure and efficient method to eliminate mosquitoes is by using natural larvicides. Underutilized soursop leaves contain secondary metabolite components that can potentially be larvicides, such as annonins, saponins, flavonoids, and tannins. Objective: This study was to determine the effectiveness of soursop leaf extract as a larvicide in controlling Aedes aegypti vectors and to determine the most effective concentration of soursop leaf extract as an Aedes aegypti larvicide. Material and Method: The study was an analytic observational study utilizing a cross-sectional methodology. This study was carried out from March to May 2022. Soursop leaves were extracted using the percolation method, employing a solvent of 96% ethanol with alkaloids, flavonoids, saponins, and tannins. Results: The soursop leaves extract yielded in this study was as much as 131.22 grams (13.12%). The most effective concentration of soursop (Annona muricata L.) leaves was 3%, with a mortality value of 100%, not much different from the value resulting from 1% temephos. The LC50 results obtained a value of 0.163%. Conclusion: Soursop leaf extract was effective as a larvicide against Aedes aegypti mosquito larvae.
Replacing n,n-diethyl-p-phenylenediamine(DPD) with polyvinyl alcohol for the non-hazardous determination of trace oxidizing agents in water
Authors: Liu Dibo 
Published: February 2024

Abstract
For decades, n,n-diethyl-p-phenylenediamine (DPD) has been used as a color indicator to detect strong oxidizing agents that can oxidize iodide in aqueous solutions. However, many consumer products that use this method are easily accessible and often used without proper waste disposal. In the present study, a novel method was developed based on the special optical properties of a red-colored complex formed by polyvinyl alcohol (PVA) and triiodide (I3-) generated from the oxidation of iodide. Using peracetic acid (PAA) as a test oxidizing agent, a liquid reagent containing 1% PVA and 0.1 g/L potassium iodide (KI) in 0.1 M pH 5.0 phosphate buffer showed strong linearity between absorption value at 485 nm and PAA concentration (≤ 5 mg/L). Test strips soaked in this liquid reagent and dried showed inconsistent color reaction with PAA, and the sensitivity was insufficient. In comparison, solid reagent in combination with effervescent powder performed with sufficient consistency and sensitivity in the reaction with PAA. The test in the form of effervescent powder has great potential to be developed into a green consumer product due to the non-hazardous properties of PVA. The health risks associated with KI can be largely reduced and should be warned for consumers.
Deep learning assisted single particle tracking for automated correlation between diffusion and function
Authors: Hatzakis Nikos , Kaestel-Hansen Jacob , de Sautu Marilina , Saminathan Anand , Scanavachi Gustavo , Correia Ricardo , Nielsen Annette Juma , Bleshoey Sara , Boomsma Wouter , Kirchhausen Tomas 
Published: February 2024

Abstract
Sub-cellular diffusion in living systems reflects cellular processes and interactions. Recent advances in optical microscopy allow the tracking of this nanoscale diffusion of individual objects with an unprecedented level of precision. However, the agnostic and automated extraction of functional information from the diffusion of molecules and organelles within the sub-cellular environment, is labor-intensive and poses a significant challenge. Here we introduce DeepSPT, a deep learning framework to interpret the diffusional 2D or 3D temporal behavior of objects in a rapid and efficient manner, agnostically. Demonstrating its versatility, we have applied DeepSPT to automated mapping of the early events of viral infections, identifying distinct types of endosomal organelles, and clathrin-coated pits and vesicles with up to 95% accuracy and within seconds instead of weeks. The fact that DeepSPT effectively extracts biological information from diffusion alone illustrates that besides structure, motion encodes function at the molecular and subcellular level.
Simultaneous determination of 37 pesticides in fresh and processed button mushroom Agaricus bisporus (Lange) Imbach
Authors: Bhandari Tulasi , Kaithamalai Bhuvaneswari , Angappan Suganthi , Gurudevan Thiribhuvanamala , Padmanaban Geetha , Chellamuthu Selvi , Venkidusamy Muralitharan , Palanisamy Karthik , Chelladurai Anusha Veeran 
Published: February 2024

Abstract

An efficient modified QuEChERS procedure was established for the simultaneous determination of 37 pesticides in fresh and processed button mushroom by employing GC/ GC-MS and LC-MS/MS. The effectiveness, reliability and accuracy of the method were assessed through various validation parameters such as linearity, LOD, LOQ, precision, accuracy, uncertainty, and matrix effect. The linearity calibration for all the selected pesticides in both LC-MS/MS and GC were ≥0.970. The LOD and LOQ values obtained were 0.003 and 0.01 µg g-1 respectively. The recoveries obtained were in the acceptable range (71.69 to 117.90%) with RSD less than 20 per cent. Matrix effect and uncertainty for all target compounds were in the acceptable range. Monitoring of button mushrooms collected from markets revealed the presence of cypermethrin residues in four of the samples tested out of 25 fresh button mushroom samples.
Recent and Projected Changes in Global Climate May Increase Nicotine Absorption and the Risk of Green Tobacco Sickness.
Authors: Ziska Lewis , Parks Robbie 
Published: February 2024

Abstract

Background. Dermal transfer of nicotine during tobacco harvest can increase green tobacco sickness (GTS), characterized by nausea, vomiting, headache and dizziness. Rainfall and temperature are established etiological factors known to increase prevalence of GTS. We aimed to analyze recent and projected trends in these factors for major tobacco growing regions to assess potential exacerbation in GTS occurrence.
Methods. We analyzed climate parameters, including trends in temperature and precipitation metrics during the tobacco harvest period for Southern Brazil; Yunnan Province, China; Andhra State, India; and North Carolina, USA (~50-year period). We applied Shared Socio-economic Pathways (SSPs) based scenarios for CMIP6, (SSPs of 1-2.6, 3-7.0 and 5-8.5 from 2020 to 2100). Established protocol for nicotine dermal patches and temperature was used as a proxy to estimate potential nicotine absorption with rising temperature.
Results. For three locations, cumulative maximum temperatures during harvest season and temperature extremes increased significantly since the 1970s. For all locations, cumulative rainfall during the harvest season also rose. Projected maximum temperatures for the harvest season increased at SSP 3-7.0 and 5-8.5 projections through 2100 for all locations. Estimates of nicotine skin absorption with rising temperature indicate significant increases for both recent changes (since the 1970s) in three of the four locations, and for all locations for the SSP projections of 3-7.0 and 5-8.5 from 2020 to 2100.
Conclusions. This study across multiple continents, highlights a potential link between recent and projected anthropogenic change and potential increases in GTS risk. Under SSP 5-8.5, nicotine absorption could increase by ~50% by the end of the century, which may have widespread impacts on the incidence of GTS, especially among younger tobacco workers.
Funding. Research Initiatives in Science and Engineering (RISE), provided $80,000 USD for support of this area of study. RMP was funded by NIEHS R00 ES033742. Data were sent to all co-authors and individuals listed in the acknowledgments who reviewed the manuscript. LHZ had full access to all the data in the study and had final responsibility for the decision to submit for publication.
Extremely high-performance production of Functional Soybean Oligosaccharides by advanced fed-batch fermentation with high cell density
Authors: Wang Yuhang , Lu Weiwei , Zhang yixin , Wang Liping 
Published: February 2024

Abstract
Soybean whey, which is a byproduct of soybean processing, is known to contain a significant quantity of functional low molecular weight substances that are challenging to separate, such as soybean oligosaccharides. This study aims to explore the high-density fermentation process of yeast PL08 fermentation process as a potential method for purifying functional soybean oligosaccharides from soybean whey, by constructing a fermentation kinetics model of PL08 cell growth, sucrose consumption, and ethanol production. The logistic model and the Luedeking-Piret model were used to analyze the data using nonlinear data fitting techniques. The linearity of the models resulted in a high coefficient of determination (R2) value of 0.98, indicating the method's effectiveness and reliability. At the 30-hour mark, the batch fermentation procedure exhibited a purity of functional oligosaccharides at 94.12%, accompanied by a simultaneous increase in ethanol concentration to 3.0% vol. In light of the results obtained from kinetic studies, a 10L exponential feeding culture was conducted, demonstrating successful maintenance of alcohol concentration below 0.10% vol. Furthermore, the maximum biomass concentration reached 50.01 g/L, while the functional soybean oligosaccharides achieved a peak purity of 95.59% within a 21-hour period.
Influence of depth and translucency on the color matching of single-shade resin composites: An in vitro study
Authors: Fernandes-e-Silva Paula , Furtado Marcieli Dias , Silva Adriana Fernandes da , Piva Evandro , Boscato Noeli , Rosa Wellington Luiz de Oliveira da 
Published: February 2024

Abstract
Objectives To evaluate whether the depth and translucency of the restoration influence the color matching of single-color composite resins.
Materials and methods Cylindrical cavities (2-and-4 mm depths) were prepared in acrylic teeth (n=10). Restorations were performed with single-shade resin composites (OC: Omnichroma, Tokuyama; VU: Vittra APS Unique, FGM) and a control multi-shade (EO: Estelite Omega, Tokuyama). The color matching was measured in instrumental analysis (CIEDE2000 color difference formula (ΔE00)) and visual analysis. The translucency of discs (2-and-4mm thickness) was obtained by ΔE00.
Results Restoration depths affected the ΔE00 values of OC and VU (p<0.05). The ΔE00 values were lower for 4-mm depth and higher for OC and VU (p< 0.05). In the visual analysis, the restoration depths did not influence the color matching. No statistically significant differences were found for each resin at different depths. VU and OC showed higher translucency scores than EO. At 2 mm, OC showed higher translucency values and there was no difference between OC and VU at 4 mm (p <0.05).
Conclusions The color matching of OC and VU was influenced by depth (instrumental analysis). While the OC had a similar color matching to EO at both depths, VU had the best color matching in both depths in the visual analysis. Single-shade materials had greater translucency than EO at different depths, and the translucency decreased with increasing depth.
Clinical significance The results of the instrumental and translucency analysis suggest that the color matching may vary with increasing depth of the single-shade resin.