bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of Indonesian traditional fermented seafood paste (terasi) made from shrimp and anchovy
Authors: Surya Reggie , Nugroho David , Kamal Nurkhalida , Petsong Kantiya 
Published: January 2024

AbstractFermented seafood paste, terasi, is a ubiquitous ingredient in Indonesian traditional cuisine. It is commonly used as a flavor enhancer due to its unique, strong, and complex flavor. Traditionally, terasi is made using planktonic shrimp (Acetes indicus) but some regional varieties of terasi include other seafoods, such as fish in their recipes. The present study aimed to explore the cultural and ethnic significance of terasi, investigating the current traditional preparation of terasi, and analyze the characteristics of terasi made from shrimp and fish. The traditional practice of terasi making in Cirebon, its birthplace, often includes the use of anchovy (Engraulidae) as an additional ingredient besides shrimp, as observed among more than 70% of local producers. Therefore, we characterized several aspects of terasi made from shrimp and anchovy (fish) under different proportions. Higher proportion of fish in terasi was associated with darker color due to browning reactions and higher microbial load, particularly proteolytic and lactic acid bacteria. Nutritionally, higher proportion of fish increased the protein content of terasi but decreased its fat content. A series of chemical analyses revealed that the addition of fish in terasi significantly increased protein hydrolysis, lipid peroxidation, and non-enzymatic browning (Maillard) reaction, thus resulting in a significant formation of toxic compounds such as histamine and acrylamide. Interestingly, organoleptic analysis showed that terasi made from an equal proportion of shrimp and fish was preferred by the panelists. Therefore, this study suggested that mixing shrimp and fish could be used as a strategy to increase consumer’s acceptance toward terasi. However, for food safety reasons, some adjustments in the fermentation period should be made in future studies since the addition of fish in terasi would increase microbial activity and accelerate chemical reactions.
Phenolic-rich lees from Philippine rice wine (tapuy) increases Caenorhabditis elegans lifespan in spite of having low antioxidant activity
Authors: Chua Sean Philippe L. , Umayat Lesley Dale , Medina Paul Mark B. 
Published: January 2024

AbstractTapuy is an indigenous wine produced in the Philippines. Rice wine fermentation produces a by-product of rice leftover and microbial biomass, collectively called lees, which usually is discarded as a waste product. However, studies have shown the potential value of lees as a healthy food source. We wanted to determine the nutritional profile of tapuy wine and its lees and their abilities to extend lifespan in Caenorhabditis elegans. Tapuy lees (7.65 g/100 g dry weight) was 18.5-fold greater in protein content compared to tapuy wine. Its sugar content (27.66 g/100 g dry weight) is similar to the tapuy wine’s sugar content (23.465 g/100 g dry weight). Through LC–MS/MS, 18.75% and 12.39% of spectral peaks in tapuy wine and lees were matched, respectively, to specific compounds, and several of them are associated with beneficial health effects. Furthermore, the phenolic content in tapuy lees (19,475.526 Gallic Acid Equivalent) is 6.5-fold greater compared to tapuy wine. Surprisingly, the DPPH and FRAP antioxidant assays show that tapuy lees had a lesser antioxidant ability compared to tapuy wine. However, C. elegans fed with supplementation of tapuy lees extract showed a 16.24% increase in mean lifespan, which is higher compared to the 6.10% increase in mean lifespan when supplemented with tapuy wine. Taking all these findings together, our study revealed that tapuy lees has a greater nutritional value than tapuy wine, and this underutilized and wastefully discarded product can be repurposed as a potential functional food.
Graphical Abstract
Do science teachers’ believes related to inquiry-based teaching affect students’ science process skills? Evidence from a multilevel model analysis
Authors: Li Xiying , Zhang Yuelai , Yu Fabi , Zhang Xingyu , Zhao Xin , Pi Zhongling 
Published: January 2024

AbstractInquiry-based science teaching has emerged as a prominent trend in science education. Nevertheless, it remains uncertain how teachers' self-efficacy in regard to the teaching of science as inquiry (TSI) affects students' science learning, especially considering the scarcity of research on its impact on students' Science Process Skills (SPSs). To investigate the impact of teachers' TSI on students' SPSs, this study conducted a questionnaire survey involving 539 eighth-grade students and 75 teachers from 7 junior high schools. Our Multilevel Model analysis results revealed a positive correlation between students' creative tendencies and SPSs. The results of the Cross-Level Moderation Models indicated that TSI moderated the relationship between students' creative tendencies and their SPSs, with this relationship strengthening as TSI increased. These study findings carry significant implications for both inquiry-based science education and teacher education.
Association between ambient particulate matter and semen quality parameters: a systematic review and meta-analysis
Authors: Bahreiny Seyed Sobhan , Bastani Mohammad-Navid , Dabbagh Mohammad Reza , Ghorbani Hamid , Aghaei Mojtaba , Zahedian Mehdi , Fard Reza Mohammadpour 
Published: January 2024

Abstract
Background
The adverse consequences of ambient particulate matter (PM) on human health have been extensively studied. However, the association between PM2.5 and PM10 μm, two common sizes of particulate matter, and semen quality remains a subject of debate. This systematic review and meta-analysis aim to investigate the relationship between ambient PM2.5 and PM10 μm exposure and semen quality parameters.

Main text
A systematic literature search was conducted using electronic databases to identify relevant studies investigating the association between (PM2.5 μm and PM10 μm) exposure and semen quality, covering the period from January 2000 to April 2023. Standard mean difference (SMD) was used to calculate pooled effect estimates with 95% confidence intervals (CIs). Furthermore, meta-regression and subgroup analyses provided additional insight into potential factors contributing to heterogeneity. The meta-analysis included a comprehensive review of nine studies with a total of 6264 participants. The findings demonstrated a significant negative correlation between ambient exposure to PM2.5 μm and PM10 μm and various parameters related to semen quality. The analysis revealed that PM2.5 exposure was linked to reduced semen volume (SMD = −0.028; 95% CI −0.055 to −0.01), total sperm count (SMD = −0.027; 95% CI −0.052 to -0.02), sperm motility (SMD = −0.156; 95% CI −0.26 to -0.04), and progressive motility (SMD = −0.194; 95% CI −0.38 to −0.01). Likewise, exposure to PM10 was associated with decreased sperm concentration (SMD = −0.036; 95% CI −0.06 to −0.01) and sperm motility (SMD = −0.93; 95% CI −0.15 to −0.02).

Conclusion
This systematic review and meta-analysis demonstrate a consistent negative association between ambient PM10 and PM2.5 μm exposure and semen quality parameters. The findings suggest that increased levels of ambient particulate matter may have an adverse influence on sperm count and motility. The results highlight the importance of addressing environmental air pollution as a potential risk factor for male reproductive health.
Impact of perceived social support on suicidal ideation among students at Ain Shams University
Authors: Hussein Rasha Saad , Yousef Shaimaa Samy 
Published: January 2024

Abstract
Background
Suicide is a significant public health issue that has long-term impacts on individuals, families, and communities. Perceived social support can reduce the frequency of suicidal ideation (SI), which is an important precursor to later attempted and completed suicide. The present study aimed to measure the prevalence of SI and perceived social support among students at Ain Shams University, compare SI and perceived social support among medical and non-medical students, and identify the factors affecting SI.

Methods
A cross-sectional study was conducted among 745 students recruited from two medical and two non-medical faculties at Ain Shams University. The data was gathered through a self-administered questionnaire, including socio-demographic characteristics, family relationships, daily habits, the Suicidal Ideation Scale (SIS), and the Oslo Social Support Scale (OSSS-3).

Results
The mean age of participants was 20.1 ± 1.4, (58.1%) were females, and (7.2%) were cigarette smokers. SIS was statistically higher among non-medical students (19.89 ± 8.58) versus (16.60 ± 7.56) among medical ones. On the other hand, OSSS-3 was statistically higher among medical students, where (48.9%) of non-medical students reported poor social support versus (43.3%) among medical ones, and only (7.1%) of non-medical students reported strong social support versus (15.1%) among medical ones. The ordinal logistic regression revealed that non-medical education (OR = 1.74), smoking (OR = 2.16), dissatisfaction and neutral satisfaction regarding family relationships (OR = 6.49 and OR = 3.24, respectively), and low and moderate degrees of perceived social support (OR = 3.11 and OR = 1.81, respectively) are significant positive predictors of SI severity.

Conclusion
Since SI is a serious issue among Ain Shams University students, screening is required as a secure element of initiatives to prevent youth suicide. As poor perceived social support was a significant predictor of SI severity, teaching parenting strategies to enhance family relationships and coping with stressful situations through lectures and media must be intensified.
Interrater reliability of the ovarian–adnexal reporting and data system magnetic resonance imaging (O‑RADS MRI)
Authors: Ramadan Zainab A , Abdelrazek Ahmed Abdel Khalek , Denewar Fatmaelzahraa Abdelfattah 
Published: January 2024

Abstract
Aim
The current study aims to evaluate interrater reliability of ovarian–adnexal reporting and data system (O-RADS) magnetic resonance imaging (MRI) in interpretation of adnexal and ovarian lesions.

Material and methods
Retrospective analysis of 131 ovarian lesions was as done for 106 consecutive female patients with adnexal and/or ovarian lesions that underwent MR imaging of the pelvis. Images interpretation was accomplished by two-blinded independent raters for cystic and solid parts of ovarian lesions. The score was 5 types classified pursuant to O-RADS.

Results
A perfect interrater agreement regarding overall O-RADS [Kappa: 0.874, P: 0.001]. There was a perfect interrater agreement of the solid component (Kappa: 0.979, 95% confidence interval (CI) 0.938–1.0, P: 0.001), enhancement degree relative to myometrium (Kappa: 0.876, 95% CI 0.781–0.971, P: 0.001) and entirely solid lesions (Kappa: 1.0, 95% CI 1.0–1.0, P: 0.001). A perfect interrater agreement for ORADS 1 (Kappa: 0.937, P: 0.001), ORADS 2 (Kappa: 0.983, P: 0.001), ORADS 3 (Kappa: 0.834, P: 0.001), ORADS 4 (Kappa: 0.827, P: 0.001) and ORADS 5 (Kappa: 0.963, P: 0.001) was present.

Conclusions
The O-RADS MRI scoring system has better characterization of adnexal masses with high interrater agreement. Overcoming limitations of this study, O-RADS, may be suggested as a basic system in assessment of adnexal masses.
Closed bowel loop obstruction by a fibrous band mimicking paraduodenal hernia
Authors: Tadrous Marco , Darweesh Ahmed Abdelmonem 
Published: January 2024

Abstract
Background
A closed-loop obstruction occurs when a section of the intestine becomes blocked at two locations along its pathway, increasing the likelihood of volvulus and ischemia. Frequently, a single adhesive band is the primary cause of a closed loop, although internal hernias from congenital defects or iatrogenic intervention in the mesentery or omentum can also become other factors. In closed-loop obstruction, computed tomography (CT) often displays a distinctive pattern where the bowel appears dilated and filled with fluid, forming a ‘C-shaped’ configuration.

Case presentation
A 43-year-old female patient presented to the emergency department complaining of acute abdominal pain and repeated bilious vomiting with no history of absolute constipation. By examination, there were tenderness, guarding and rigidity. Her medical history includes type 1 diabetes since the age of 9 years and her surgical history included a onetime cesarean section and negative history of laparoscopic interventions. Ultrasound was done as a first-line investigation. It showed a few dilated bowel loops in addition to moderate intraperitoneal free fluid and could not detect the cause of bowel dilatation; therefore, non-contrast CT scan was requested and revealed the following findings: Two bowel loops exhibited distension and mucosal edema, and the configuration of bowel loops resembled a distinctive C-shape.

Conclusion
Distinguishing between adhesive small bowel obstruction (SBO) and paraduodenal hernia relies on clinical history, imaging features, and risk factors. Adhesive SBO often stems from prior surgery or inflammation and may exhibit ‘beak’ or ‘whorl’ signs on CT scans.
Community health worker training to reduce mental health and substance use stigma towards patients who have disengaged from HIV/TB care in South Africa: protocol for a stepped wedge hybrid type II pilot implementation trial
Authors: Myers Bronwyn , Regenauer Kristen S. , Rose Alexandra , Johnson Kim , Ndamase Sibabalwe , Ciya Nonceba , Brown Imani , Joska John , Bassett Ingrid V. , Belus Jennifer M. , Ma Tianzhou , Sibeko Goodman , Magidson Jessica F. 
Published: January 2024

Abstract
Background
South Africa has deployed community health workers (CHWs) to support individuals to enter and stay in HIV/TB care. Although CHWs routinely encounter patients with mental health (particularly depression) and substance use (SU) conditions that impact their engagement in HIV/TB care, CHWs are rarely trained in how to work with these patients. This contributes to mental health and SU stigma among CHWs, a known barrier to patient engagement in care. Mental health and SU training interventions could reduce CHW stigma and potentially improve patient engagement in care, but evidence of the feasibility, acceptability, and preliminary effectiveness of these interventions is scarce. Therefore, we designed a hybrid type 2 effectiveness-implementation pilot trial to evaluate the implementation and preliminary effectiveness of a CHW training intervention for reducing depression and SU stigma in the Western Cape, South Africa.

Methods
This stepped wedge pilot trial will engage CHWs from six primary care clinics offering HIV/TB care. Clinics will be block randomized into three-step cohorts that receive the intervention at varying time points. The Siyakhana intervention involves 3 days of training in depression and SU focused on psychoeducation, evidence-based skills for working with patients, and self-care strategies for promoting CHW wellness. The implementation strategy involves social contact with people with lived experience of depression/SU during training (via patient videos and a peer trainer) and clinical supervision to support CHWs to practice new skills. Both implementation outcomes (acceptability, feasibility, fidelity) and preliminary effectiveness of the intervention on CHW stigma will be assessed using mixed methods at 3- and 6-month follow-up assessments.

Discussion
This trial will advance knowledge of the feasibility, acceptability, and preliminary effectiveness of a CHW training for reducing depression and SU stigma towards patients with HIV and/or TB. Study findings will inform a larger implementation trial to evaluate the longer-term implementation and effectiveness of this intervention for reducing CHW stigma towards patients with depression and SU and improving patient engagement in HIV/TB care.

Trial registration
ClinicalTrials.gov NCT05282173. Registered on 7 March 2022.
Pain intensity, physical activity, quality of life, and disability in patients with mechanical low back pain: a cross-sectional study
Authors: Ekediegwu Ezinne Chika , Onwukike Chukwuneke Vivian , Onyeso Ogochukwu Kelechi 
Published: January 2024

Abstract
Background
Poorly managed mechanical low back pain (MLBP) and its sequelae, such as severe pain, physical inactivity, and disability, negatively impact patients’ quality of life (QoL). The study aimed to determine the pain intensity (PI), physical activity (PA), QoL, and disability, the association between selected sociodemographic variables and PI, PA, QoL, and disability, and the relationship between PI, PA, QoL, and disability among Nigerians with chronic MLBP.

Methods
This cross-sectional study employed a consecutive sampling technique. Outcome measures included the Numeric Pain Scale, International Physical Activity Questionnaire-Short Form, WHO Quality-of-Life Brief, and Oswestry Disability Index for PI, PA, QoL, and disability, respectively. Descriptive statistics were used to summarize participants’ sociodemographic variables. Chi-square, Spearman’s correlation, and structural equation modeling (SEM) were used for inferential analyses.

Results
Two hundred and fifty chronic MLBP patients comprising 154 females and 96 males, completed the study. The mean PA, PI, QoL, and disability levels were 1118.03MET ± 615.30, 5.97 ± 2.69, 73.45% ± 14.21, and 21.7% ± 18.94, respectively. There was a significant correlation between PA and QoL (rho = 0.36, p = 0.001), PA and disability (rho = −0.42, p = 0.010), QoL and disability (rho = −0.21, p = 0.008), QoL and PI (rho = −6.72, p = 0.025), PI and disability (rho = 0.90, p = 0.022). Aside from age and PA (χ2 = 8.52, p = 0.045), there was no significant association between the sociodemographic variables and PI, PA, QoL, or disability. SEM showed a strong positive association between PI and disability (β = 0.80, p < 0.001).

Conclusion
Individuals with chronic MLBP had a low PA, moderate QoL, and significant disability. Incorporating PA, QoL, and disability assessments may enhance the evaluation and management of MLBP.
Platelet to lymphocyte ratio: can it be an early economical mortality predictor of AKI patients?
Authors: Purkayastha Arnab , Kalwar Amit , Firdaus Zakia , Nath Bhaskar Kanti , Bhattacharjee Prithwiraj 
Published: January 2024

Abstract
Background
Acute kidney injury (AKI) affects over 13 million individuals annually worldwide, resulting in 1.7 million deaths. The potential long-term progression to chronic kidney disease (CKD) and renal failure, as well as the acute use of health care resources associated with acute kidney injury (AKI), impose enormous costs on society. The platelet-to-lymphocyte ratio (PLR) has emerged as a useful economical marker for detecting changes in platelet and lymphocyte counts owing to acute inflammatory and prothrombotic states. This study aimed to determine the PLR in patients with AKI and evaluate the in-hospital mortality.

Results
The median PLR was compared between the non-survivor and survivor groups, and it was determined that the non-survivor group had a significantly higher PLR. ( p < 0.001) For further subgroup analysis, the PLR was stratified into three groups: ≤ 100, 101–200, and > 200. Significantly more patients were demised in the PLR group 101–200 than in the PLR group ≤ 100, while all of the patients died in the PLR group greater than 200. The group with a PLR > 200 had a higher SOFA score > 10 (p = 0.006), a lower eGFR (p = 0.001), and higher platelet counts (p = 0.001), higher serum creatinine (p = 0.001), BUN (p < 0.001), and procalcitonin levels (p = 0.007). In multivariate Logistic regression analysis to predict the mortality outcome, PLR (OR 1.051; 95% CI, 1.016–1.087; p = 0.004) was identified as one of the significant indicators predicting AKI mortality. Other statistically significant indicators included SOFA scores (OR 2.789; 95% CI, 1.478–5.260; p = 0.002), procalcitonin levels (OR 0.898; 95% CI, 0.818–0.987; p = 0.025), and duration of hospital stay (OR 0.494; 95% CI, 0.276–0.886; p = 0.017). The ROC curve for the PLR yielded a value of 0.803 [95% CI, 0.720–0.886; p < 0.001] with the optimal cutoff value for the PLR to determine prognosis being 107.905, with a sensitivity of 82.5% and a specificity of 51.2%.

Conclusion
PLR plays a significant role in the early prediction of prognosis (survival or death) for patients with AKI in ICU on a short-term basis.
Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea
Authors: Elfeky Seham Ezzat Fathy , Ali Asmaa , Moazen Eman M. , Alhassoon Mohammad Hamad , Elzanaty Nesma A. , Alazmi Nouf Mubarak , Wu Liang , Saleh Mai M. 
Published: January 2024

Abstract
Background
Chronic inflammation plays a crucial role in developing various cardiovascular and metabolic disorders. Obstructive sleep apnea (OSA) is a unique condition characterized by the coexistence of cardiovascular and metabolic disturbances, where chronic inflammation may exacerbate disease progression and severity. This study investigated how different hematological inflammatory cells and mediators can serve as predictive indicators of severe OSA.

Methods
In a retrospective cohort study, 150 patients suspected of having obstructive sleep apnea (OSA) underwent polysomnography (PSG) to confirm the diagnosis. Based on their apnea-hypopnea index (AHI), the patients were categorized into three groups: mild, moderate, and severe OSA. Blood samples were collected for the assessment of inflammatory blood cells and mediators at the time of diagnosis.

Results
Among the 150 patients studied, 90 were diagnosed with OSA, and 43 had severe OSA, representing a prevalence rate of 47.7%. Patients with severe OSA were notably older and more likely to have diabetes mellitus and hypertension. After adjusting for age and sex, each one-unit increase in Systemic Inflammatory Response Index (SIRI), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) levels was associated with a doubling in the likelihood of having moderate and severe OSA (p < 0.05 for all). However, hypertension was linked to a 16-fold increase in the likelihood of moderate and severe OSA (p = 0.01).

Conclusion
Our research indicates that comorbidity and inflammatory cells and markers (SIRI, CRP, and ESR) are significantly related to the severity of OSA.