bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-pharmacological interventions to support coronary artery bypass graft (CABG) patient recovery following discharge: protocol for a scoping review
Authors: Billard Justin Nathan , Wells Robert , Farrell Alison , Curran Janet A , Sheppard Gillian 
Published: January 2024

BackgroundIn Canada, approximately 15 000 people undergo coronary artery bypass grafting (CABG) each year. However, 9.5% of these patients are urgently readmitted to hospital within 30 days of surgery. Postoperative interventions following discharge play an important role in reducing readmissions and improving CABG patient outcomes. Therefore, it is important to determine effective interventions available to enhance CABG patient recovery following postoperative discharge.ObjectivesOur scoping review aims to identify non-pharmacological interventions available to support recovery of patients who are discharged after CABG in the community setting.MethodsThe methodological framework described by Arksey and O’Malley will be applied to this review. Our search strategy will include electronic databases (Medline, Embase, Cochrane Library and CINAHL), and studies will be screened and reviewed by two independent reviewers. Studies looking at non-pharmacological interventions targeting patients who are discharged after CABG will be included. Preliminary searches were conducted March 2022 and following abstract screening, full-text screening was completed May 2023. Data extraction is planned to begin September 2023 with an expected finish date of October 2023. The study is expected to be completed by January 2024.Ethics and disseminationThis scoping review will retrieve and analyse previously published studies in which informed consent was obtained by primary investigators. Therefore, no ethical review or approval will be required. This scoping review aims to enumerate available non-pharmacological interventions to support recovery of patients who are discharged after CABG and identify gaps in postoperative recovery after discharge to support the development of innovative and targeted interventions. On completion of this review, we will ensure broad dissemination of our findings through peer-reviewed, open-access journals, conference presentations and hold meetings to engage stakeholders, including clinicians, policy makers and others.
Comparative analysis of immune infiltrates in head and neck cancers across anatomical sites
Authors: Muijlwijk Tara , Nijenhuis Dennis N L M , Ganzevles Sonja H , Brink Arjen , Ke Changlin , Fass Joseph N , Rajamanickam Venkatesh , Leemans C René , Koguchi Yoshinobu , Fox Bernard A , Poell Jos B , Brakenhoff Ruud H , van de Ven Rieneke 
Published: January 2024

BackgroundThe response rate to immune checkpoint inhibitors targeting programmed cell death 1 (PD-1) receptor is 13%–18% for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Detailed understanding of the tumor immune microenvironment (TIME) is crucial in order to explain and improve this response rate. HNSCCs arise at various anatomical locations including the oral cavity, hypopharynx, larynx and oropharynx. Studies directly comparing immune infiltration between anatomical sites are scarce. Since the distinct locations could drive deviating microenvironments, we questioned whether the immune composition varies across these HNSCC sites.MethodsHere, we characterized the TIME of 76 fresh tumor specimens using flow cytometry and performed single-cell RNA-sequencing on nine head and neck tumor samples.ResultsWe found major differences in the composition of the TIME between patients. When comparing anatomical sites: tumors originating from the oral cavity had higher T cell infiltrates than tumors from other anatomical sites. The percentage of tumor-infiltrating T-lymphocytes positive for the immune checkpoint PD-1 varied considerably between patients, with the highest fraction of PD-1+ T cells found in larynx squamous cell carcinomas (SCCs). While we had hypothesized that the anatomical sites of tumor origin would drive sample clustering, our data showed that the type of TIME was more dominant and was particularly driven by the fraction of T cells positive for PD-1. Moreover, a high proportion of PD-1+ CD8+ T cells associated with an improved overall survival. Using single-cell RNA-sequencing, we observed that PD-1 expression was highest in the CD8-ENTPD1 tissue resident memory T cell/exhausted T cell and CD4-CXCL13 type 1 T helper cell clusters.ConclusionsWe found that oral cavity SCCs had the highest frequencies of T cells. We also observed considerable interpatient heterogeneity for PD-1 on T cells, with noticeably higher frequencies of PD-1+ CD4+ T helper cells in larynx SCCs. Within the entire cohort, a higher fraction of CD8+ T cells positive for PD-1 was linked to improved overall survival. Whether the fraction of PD-1+ T cells within the TIME enables immune checkpoint inhibitor response prediction for patients with head and neck cancer remains to be determined.
CCR5andCCL5gene expression in colorectal cancer: comprehensive profiling and clinical value
Authors: Battaglin Francesca , Baca Yasmine , Millstein Joshua , Yang Yan , Xiu Joanne , Arai Hiroyuki , Wang Jingyuan , Ou Fang-Shu , Innocenti Federico , Mumenthaler Shannon M , Jayachandran Priya , Kawanishi Natsuko , Lenz Annika , Soni Shivani , Algaze Sandra , Zhang Wu , Khoukaz Taline , Roussos Torres Evanthia , Seeber Andreas , Abraham Jim P , Lou Emil , Philip Philip A , Weinberg Benjamin A , Shields Anthony F , Goldberg Richard M , Marshall John L , Venook Alan P , Korn W Michael , Lenz Heinz-Josef 
Published: January 2024

BackgroundThe C-C motif chemokine receptor 5 (CCR5)/C-C motif chemokine ligand 5 (CCL5) axis plays a major role in colorectal cancer (CRC). We aimed to characterize the molecular features associated withCCR5/CCL5expression in CRC and to determine whetherCCR5/CCL5levels could impact treatment outcomes.Methods7604 CRCs tested with NextGen Sequencing on DNA and RNA were analyzed. Molecular features were evaluated according toCCR5andCCL5tumor gene expression quartiles. The impact on treatment outcomes was assessed in two cohorts, including 6341 real-world patients and 429 patients from the Cancer and Leukemia Group B (CALGB)/SWOG 80405 trial.ResultsCCR5/CCL5expression was higher in right-sided versus left-sided tumors, and positively associated with consensus molecular subtypes 1 and 4. HigherCCR5/CCL5expression was associated with higher tumor mutational burden, deficiency in mismatch repair and programmed cell death ligand 1 (PD-L1) levels. Additionally, highCCR5/CCL5were associated with higher immune cell infiltration in the tumor microenvironment (TME) of MMR proficient tumors. Ingenuity pathway analysis revealed upregulation of the programmed cell death protein 1 (PD-1)/PD-L1 cancer immunotherapy pathway, phosphatase and tensin homolog (PTEN) and peroxisome proliferator-activated receptors (PPAR) signaling, and cytotoxic T-lymphocyte antigen 4 (CTLA-4) signaling in cytotoxic T lymphocytes, whereas several inflammation-related pathways were downregulated. LowCCR5/CCL5expression was associated with increased benefit from cetuximab-FOLFOX treatment in the CALGB/SWOG 80405 trial, where significant treatment interaction was observed with biologic agents and chemotherapy backbone.ConclusionsOur data show a strong association betweenCCR5/CCL5gene expression and distinct molecular features, gene expression profiles, TME cell infiltration, and treatment benefit in CRC. Targeting the CCR5/CCL5 axis may have clinical applications in selected CRC subgroups and may play a key role in developing and deploying strategies to modulate the immune TME for CRC treatment.
Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity
Authors: Holten Karen , Paulshus Sundlisæter Nina , Sexton Joseph , Nordberg Lena Bugge , Uhlig Till , Kvien Tore K , Solomon Daniel H , Haavardsholm Espen A , Lillegraven Siri , Aga Anna-Birgitte 
Published: January 2024

ObjectivesTo explore the performance of the EULAR-initiated patient-reported Rheumatoid Arthritis Impact of Disease (RAID) questionnaire in relation to flares in disease activity, including comparison with other disease activity outcomes.MethodsPatients with rheumatoid arthritis in sustained remission were randomised to continued stable treatment or tapering in the ARCTIC REWIND project. In patients with flares within 12 months, we compared RAID (total score and components) at the flare visit with the visit prior to and the visit following flare, using Wilcoxon signed-rank test. Similar analyses were performed for patient global assessment, Disease Activity Score (DAS) and C reactive protein (CRP). The discriminative accuracies of RAID, patient global assessment, DAS and CRP with respect to disease activity flares were assessed by receiver operating characteristic (ROC) analyses based on logistic regression models. Flare was defined as a combination of DAS >1.6, a DAS increase ≥0.6 and ≥two swollen joints (of 44 examined) or could be recorded if patient and rheumatologist agreed that a clinically significant flare had occurred.ResultsIn total, 248 patients were included in the analyses, with 56 flares. RAID, patient global assessment, DAS and CRP all changed significantly at the visits related to flare (p<0.001). Area under the curve (95% CI) values indicated that RAID (0.88 (0.83 to 0.93)) was significantly more accurate than CRP (0.76 (0.69 to 0.84)) in discriminating flare, and less accurate than patient global assessment (0.92 (0.87 to 0.97)) and DAS (0.94 (0.90 to 0.98)). The RAID components with highest and lowest discriminative accuracies were pain (0.91 (0.86 to 0.95)) and sleep (0.69 (0.59 to 0.79)).ConclusionDisease activity flares were associated with a significant increase in median RAID, supporting its ability to respond to flare.Trial registration numberNCT01881308.
Early life involvement in food skills is associated with children’s cooking skills: a longitudinal analysis
Authors: Sahye-Pudaruth Sandhya , Ma David W.L. , Prashad Michael , Haines Jess ,   Guelph Family Health Study
Published: January 2024

Engaging young children in food skills such as food planning and preparation early in life may be an important predictor of later child cooking skills. The aim of this study was to examine whether early life involvement in food skills (mean age at baseline = 3.6 years) is prospectively associated with cooking skills among a sample of 60 children (mean age at follow-up = 10.0 years; 83% White) from the Guelph Family Health Study, an ongoing cohort study examining the effect of a home-based obesity prevention intervention. Early life involvement in food skills, i.e., child involvement in grocery shopping and meal preparation, was reported by parents at baseline. Children self-reported their cooking skills at follow-up. After adjusting for child age, child sex, parent age, household income, and intervention status, early life involvement in food skills was significantly associated with later child cooking skills (β = 0.24, 95% CI (0.02–0.45), p = 0.03). Future studies with larger and more socioeconomically, geographically, and racially diverse samples are needed to confirm these findings.
Medium-range structure modifications induced by Fe3+/Fetot. in volcanic glasses: a low-frequency Raman spectroscopy study
Authors: Cassetta Michele 
Published: January 2024

AbstractHere is carried out a Raman scattering study on the boson peak evolution of an iron-rich peralkaline rhyolite in function of both the iron oxidation state and the glass transition temperature. ﻿It is reported here that the distribution of low-frequency modes in the boson peak range is only slightly affected for an iron ratio (Fe3+/Fetot.) from 0.83 down to 0.24. ﻿Their distribution does not change in the boson peak range as a function of Fe3+/Fetot., until the reduction process starts to modify the glass network from a dominantly fourfold coordinated Fe3+ structures into a structure mostly governed by fivefold coordinated Fe2+. This trend is also related to a decreasing glass transition temperature peak, mirroring an increasing proportion of weakest bonds with respect to the stronger ones.
DISENTANGLING THE INNOVATION ORIENTATION, INTELLECTUAL CAPITAL, AND DYNAMIC INNOVATION CAPABILITY RELATIONSHIPS IN EMERGING ECONOMY START-UPS
Authors: KARADAĞ HANDE , SAHIN FARUK , MATEMANE REON 
Published: January 2024

Purpose: Based on the Dynamic Capabilities View (DCV) and Knowledge-based View (KBV), this study investigates the relationships between intellectual capital (IC) resources and dynamic innovation capabilities in the context of new ventures. Design/methodology/approach: Data for the study is collected from 311 start-up firms in Turkey and is analysed via Structural Equation Modelling. Findings: The results indicate that the effects of human capital and social capital on dynamic innovation capability are fully mediated by innovation orientation (IO). Besides, dynamic innovation capability is found to be strongly associated with innovation performance. Practical implications: In the study, IO is suggested as a useful mechanism for encouraging the deployment of an innovation focus in all functions of a firm for attaining long-term sustained competitiveness. Thereby, the findings are expected to present important implications for start-up founders and policy-makers, by highlighting the importance of knowledge management and investing in human and social capital resources for generating the capability to innovate. Originality/value: The most significant contribution of the study is the development of a model suggesting IO as a mediating variable between the IC resources and dynamic innovation capability relationship in the context of start-up firms. Furthermore, the findings indicate a positive and significant association between the dynamic innovation capability and innovation performance in these economic units.
Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth
Authors: Begovich Kyle , Schoolmeesters Angela , Rajapakse Navin , Martinez-Terroba Elena , Kumar Maneesh , Shakya Arvind , Lai Chon , Greene Steven , Whitefield Brandon , Okano Akinori , Mali Venkat , Huang Shenlin , Chourasia Aparajita H. , Fung Leah 
Published: January 2024

Abstract
Mutations within the oncogene KRAS drive an estimated 25% of all cancers. Only allele-specific KRAS G12C inhibitors are currently available and are associated with the emergence of acquired resistance, partly due to upstream pathway reactivation. Given its upstream role in the activation of KRAS, son of sevenless homolog 1 (SOS1), has emerged as an attractive therapeutic target. Agents that target SOS1 for degradation could represent a potential pan-KRAS modality that may be capable of circumventing certain acquired resistance mechanisms. Here, we report the development of two SOS1 cereblon-based bifunctional degraders, BTX-6654 and BTX-7312, cereblon-based bifunctional SOS1 degraders. Both compounds exhibited potent target-dependent and -specific SOS1 degradation. BTX-6654 and BTX-7312 reduced downstream signaling markers, pERK and pS6, and displayed antiproliferative activity in cells harboring various KRAS mutations. In two KRAS G12C xenograft models, BTX-6654 degraded SOS1 in a dose-dependent manner correlating with tumor growth inhibition, additionally exhibiting synergy with KRAS and MEK inhibitors. Altogether, BTX-6654 provided preclinical proof of concept for single-agent and combination use of bifunctional SOS1 degraders in KRAS-driven cancers.
Acceptability of Personalized Lung Cancer Screening Program Among Primary Care Providers
Authors: Resong Paul J. , Niu Jiangong , Duhon Gabrielle F. , Foxhall Lewis E. , Shete Sanjay , Volk Robert J. , Toumazis Iakovos 
Published: January 2024

Abstract

Current lung cancer screening (LCS) guidelines rely on age and smoking history. Despite its benefit, only 5%–15% of eligible patients receive LCS. Personalized screening strategies select individuals based on their lung cancer risk and may increase LCS's effectiveness. We assess current LCS practices and the acceptability of personalized LCS among primary care providers (PCP) in Texas. We surveyed 32,983 Texas-based PCPs on an existing network (Protocol 2019-1257; PI: Dr. Shete) and 300 attendees of the 2022 Texas Academy of Family Physicians (TAFP) conference. We analyzed the responses by subgroups of interest. Using nonparametric bootstrap, we derived an enriched dataset to develop logistic regression models to understand current LCS practices and acceptability of personalized LCS. Response rates were 0.3% (n = 91) and 15% (n = 60) for the 2019–1257 and TAFP surveys, respectively. Most (84%) respondents regularly assess LCS in their practice. Half of the respondents were interested in adopting personalized LCS. The majority (66%) of respondents expressed concerns regarding time availability with the personalized LCS. Most respondents would use biomarkers as an adjunct to assess eligibility (58%), or to help guide indeterminate clinical findings (63%). There is a need to enhance the engagement of Texas-based PCPs in LCS. Most of the respondents expressed interest in personalized LCS. Time availability was the main concern related to personalized LCS. Findings from this project highlight the need for better education of Texas-based PCPs on the benefits of LCS, and the development of efficient decision tools to ensure successful implementation of personalized LCS.

Prevention Relevance:
Personalized LCS facilitated by a risk model and/or a biomarker test is proposed as an alternative to existing programs. Acceptability of personalized approach among PCPs is unknown. The goal of this study is to assess the acceptability of personalized LCS among PCPs.
Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1
Authors: Garbutt Tiffany A. , Wang Zhenhua , Wang Haofei , Ma Hong , Ruan Hongmei , Dong Yanhan , Xie Yifang , Tan Lianmei , Phookan Ranan , Stouffer Joy A. , Vedantham Vasanth , Yang Yuchen , Qian Li , Liu Jiandong 
Published: January 2024

BACKGROUND:
During the neonatal stage, the cardiomyocyte undergoes a constellation of molecular, cytoarchitectural, and functional changes known collectively as cardiomyocyte maturation to increase myocardial contractility and cardiac output. Despite the importance of cardiomyocyte maturation, the molecular mechanisms governing this critical process remain largely unexplored.

METHODS:

We leveraged an in vivo mosaic knockout system to characterize the role of
Carm1
, the founding member of protein arginine methyltransferase, in cardiomyocyte maturation. Using a battery of assays, including immunohistochemistry, immuno-electron microscopy imaging, and action potential recording, we assessed the effect of loss of
Carm1
function on cardiomyocyte cell growth, myofibril expansion, T-tubule formation, and electrophysiological maturation. Genome-wide transcriptome profiling, H3R17me2a chromatin immunoprecipitation followed by sequencing, and assay for transposase-accessible chromatin with high-throughput sequencing were used to investigate the mechanisms by which CARM1 (coactivator-associated arginine methyltransferase 1) regulates cardiomyocyte maturation. Finally, we interrogated the human syntenic region to the H3R17me2a chromatin immunoprecipitation followed by sequencing peaks for single-nucleotide polymorphisms associated with human heart diseases.

RESULTS:

We report that mosaic ablation of
Carm1
disrupts multiple aspects of cardiomyocyte maturation cell autonomously, leading to reduced cardiomyocyte size and sarcomere thickness, severe loss and disorganization of T tubules, and compromised electrophysiological maturation. Genomics study demonstrates that CARM1 directly activates genes that underlie cardiomyocyte cytoarchitectural and electrophysiological maturation. Moreover, our study reveals significant enrichment of human heart disease–associated single-nucleotide polymorphisms in the human genomic region syntenic to the H3R17me2a chromatin immunoprecipitation followed by sequencing peaks.

CONCLUSIONS:
This study establishes a critical and multifaceted role for CARM1 in regulating cardiomyocyte maturation and demonstrates that deregulation of CARM1-dependent cardiomyocyte maturation gene expression may contribute to human heart diseases.
No Evidence for an Association of HIV and Antiviral Treatment With Changes in Framingham Cardiovascular Risk Score in the Ndlovu Cohort Study
Authors: Verstraeten Rita , Vos‐Seda Alinda G. , Boateng Daniel , Scheuermaier Karine , Tempelman Hugo , Barth Roos E. , Devillé Walter , Coutinho Roel A. , Venter Francois , Grobbee Diederick E. , Klipstein‐Grobusch Kerstin 
Published: January 2024

Background
HIV and antiretroviral therapy (ART) have been associated with increased cardiovascular disease (CVD) risk in high‐income countries. The authors studied the longitudinal association between HIV and ART and nonlaboratory Framingham Risk Score (FRS) in a middle‐income country.

Methods and Results

This longitudinal analysis of the NCS (Ndlovu Cohort Study), South Africa used baseline to 36‐month follow‐up data. Demographics, HIV, ART status, and cardiometabolic measures were obtained. FRS was used as a CVD risk measure. Through linear mixed models, FRS trends over time and the association with HIV were studied. Analysis included 1136 participants, with 609 (54%) having HIV, and 495 (81%) taking ART. At baseline, 9.8% of participants had a high FRS. People living with HIV (PLHIV) had a 3.2% lower FRS than HIV‐negative participants (
P
<0.001). FRS increased similarly for both groups over time. Other factors associated with FRS were secondary and higher education (ß value: −0.075,
P
<0.001; ß value: −0.084,
P
<0.001) and alcohol consumption (ß value: 0.011,
P
<0.001).

Conclusions
CVD risk increased for all participants over 36 months, suggesting classic risk factors rather than HIV status or ART to be drivers of CVD risk. People living with HIV had a significantly lower FRS than their HIV‐negative counterparts, possibly related to HIV itself or a more frequent interaction with healthcare services. No association of HIV and ART with changes in FRS over 36 months was observed, suggesting the need for research using clinical endpoints to elucidate the effects of HIV and ART on CVD risk. Population‐based prevention of CVD risk factors in sub‐Saharan Africa is warranted, regardless of HIV status.