bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolutionary adaptation perspectives on childcare with references to life history plasticity in the modern world: Brazil, Russia, and the USA
Authors: Semenova Olga , Figueredo Aurelio , Tokumaru Rosana , de Felipe Renata , Lucci Tania , Salmon Catherine , Patch Emily , Zambrano Rachel , Bytovskaya Marina 
Published: February 2024

Abstract

Introduction. The cooperative breeding framework suggests that help from extended family members with childrearing is important adaptation for our species survival, and it is universal. However, the degree of alloparental help may vary between societies, families, and over time. We hypothesized that maternal and paternal effort, as well as alloparental carе, would depend both upon resource availability (SЕS) and different mating opportunities for males and females in three countries: Brazil, Russia, and the USA. Methods. We analyzed the intergenerational interactions between family members during childcare via Structural Equation Modeling (SEM) in R-software. Online samples were collected from Brazil (N = 603), Russia (N = 620), and the USA (N = 314). Results and discussion. The results of our study are consistent with previous research on life history (LHT) plasticity, which has shown a negative correlation between low SES and parental effort. However, our models indicated a possible cultural difference in the estimates of poverty paths: in Brazilian and American samples, SES had a greater impact on paternal care than on maternal, while in Russia, poverty had a greater effect on mothers’ effort. This reversed effect size on maternal versus paternal effort in Russia may suggest that Russian mothers experience a trade-off between working outside the home and direct childcare, while Russian fathers may adopt a “faster” LHT strategy as they are the limited sex in the mating pool. Our findings also demonstrate that the parental effort of both parents was positively associated, indicating their mutualistic relationship. We also found that maternal grandparents usually compensate the lack of paternal effort, but their help, as well as the help of paternal grandparents, was indifferent to the poverty cues.
Solar Physics paper
Authors: ABDULAMEER NOUR , allawi habeeb , ujvari Balazs 
Published: February 2024

Abstract
This study examines the complex relationships among high-energy solar particle events (SEPs), solar flares, and coronal mass ejections (CMEs) at the onset of Solar Cycle 25. We investigate the sources and characteristics of high-energy solar particles and explore the dynamics of solar flares and CMEs within this evolving solar cycle.
While CMEs are often associated with SEPs, their occurrence isn't guaranteed due to the intricate interplay of magnetic fields and propagation conditions. Understanding this variability is crucial for improving predictive capabilities related to space weather events.
We leverage advanced observational techniques to analyze CMEs and assess their correlations with solar cycle activity. Our research also considers the potential impacts of these solar events on Earth's space weather and technology infrastructure.
Comparisons with previous solar cycles provide valuable insights into the evolving nature of solar activity. We conclude by discussing the current state of predictive modeling and forecasting, emphasizing the need for continued advancements in space weather prediction models. Overall, this study contributes to our understanding of solar physics and space weather, particularly regarding the dynamics of high-energy solar particle events and their relationships with flares and CMEs during Solar Cycle 25's early stages.
Approximately orthogonal non-negative Tucker decomposition with graph regularized for multiway dimensionality reduction
Authors: Gao Xiang , Lu Linzhang , Liu Qilong 
Published: February 2024

Abstract
Non-negative Tucker decomposition (NTD) is one of the renowned technique in feature extraction and representation for non-negative high-dimensional tensor data. The main focus behind NTD is how to factorize the data to get hold of a high quality data representation from multidimensional directions. However, NTD does not conserve the geometrical structure of the data space and does not consider relationship and property among columns of the factor matrices. In this paper, by using approximately orthogonal constraint and graph regularized constraint , we manage to capture nonlinear local features of data space and further enhance expressiveness of the NTD clustering method. First, based on the uni-side and bi-side approximate orthogonality, we propose two novel approximately orthogonal non-negative Tucker decomposition with graph regularized models, which not only in part make factor matrix tend to be orthogonality, but also preserve the geometrical information from high-dimensional tensor data. Then we develop the iterative updating algorithm depended on multiplicative update rule to solve the proposed models, and provide its convergence and computational complexity. Finally, we use numerical experimental results to demonstrate the effectiveness, robustness and efficiency of the proposed new methods on the real-world image datasets.
Effects of phenylephrine and ephedrine on the Analgesia Nociception Index (ANI) and Nociception Level (NOL)
Authors: Kuroki Masahiro , Onodera Yu , Okada Masayuki , Nakane Masaki 
Published: February 2024

Abstract

Background: There is growing evidence that perinatal HIV infection and exposure affect salivary pH and flow rate in children in most parts of the world, but not against the background of caries and the African demographic. This study aimed to evaluate the impact of HIV infection as well as exposure on salivary properties and their influence upon the dental caries experience among school-aged children in Nigeria.
Method: This cross-sectional study assessed the salivary flow rates and salivary pH of HIV infected and exposed school-aged (4-11) children receiving care at a Nigerian tertiary hospital. A total of 266 consenting participants which comprised of three groups as follows: 1) HIV Infected (HI) (n = 87), 2) HIV Exposed and Uninfected (HEU) (n=82) and 3) HIV Unexposed and Uninfected (HUU) (n=97) were recruited for the study. Questionnaires completed by parents/guardians were used for data collection. Three calibrated dentists performed oral examinations for dental caries. International Caries Detection and Assessment Scores (ICDAS) was used and presented as dmft/DMFT. Salivary pH was measured using MColourpHastTM pH indicator strips, while salivary flow rate was determined by collecting unstimulated whole saliva using the suction method. Data analysis relied on comparative statistics to determine the correlation between HIV exposure and infection on salivary pH and flow rates.
Result: Across the groups, (HI, HEU, and HUU) mean pH of the HI was significantly less than that of HEU and HUU. Similarly, there was a statistically significant difference in the SFR across the three groups (p = 0.004). Other variables such as gender, age and oral hygiene status expressed by the gingival inflammatory scores had no significant influence on the pH and SFR of study participants. There was a rather unexpected positive correlation of DMFT of HI and HEU groups with increasing salivary flow rate; though, the relationship was weak and not significant.
Conclusion: Perinatal HIV exposure and infection significantly impact salivary pH and flow rate among school-aged children in Nigeria. The findings of this study imply that HIV infection influenced the salivary pH, while HIV maternal exposure (without infection) impacted salivary flow rates when compared to the controls.
The Role and Mechanism of Dental Pulp Stem Cells in Highly Porous Microcarriers Forming New Micro-tissues to Accelerate Mandibular Bone Defect Repair
Authors: Shen RenZe , Wang YiCheng , Huang JiaCheng , Tan YongMei , Ke SongXia , Zhou ZiQing , Zheng WeiWen , Chen AiZheng , Ye ZhanChao 
Published: February 2024

Abstract
Objective
Dental pulp stem cells (DPSCs) exhibit strong differentiation and proliferation capabilities but are often discarded. This experiment aimed to prepare PLGA (poly lactic-co-glycolic acid) highly open porous microspheres (HOPMS) and form microscale cell carriers with DPSCs, exploring their efficacy and mechanism in promoting alveolar bone defect repair.
Methods
Rat dental pulp stem cells were cultured and identified. PLGA HOPMS were prepared and their porosity, pore size, degradation rate, and PH change were evaluated. Cytological experiments examined the effects of PLGA HOPMS on cell proliferation, mineralized nodule formation, mineralization gene, and inflammatory factor expression. Cells were transduced with lentivirus for fluorescence marking and co-cultured with PLGA HOPMS to form microscale cell carriers. Subcutaneous and intraosseous implantations were performed to investigate their biocompatibility, angiogenesis, and inflammatory response.
Results
The size and pore diameter of PLGA HOPM were adjustable. PLGA HOPMS promoted the formation of mineralized nodules, mineralization gene expression, and exhibited no cytotoxicity. Subcutaneous experiments demonstrated that microscale cell carriers had excellent biocompatibility with no significant immune rejection. Intraosseous experiments confirmed that this material promoted osteogenesis and angiogenesis. Conclusion: PLGA HOPMS loaded with DPSCs effectively promoted bone and vascular formation in alveolar bone defect repair, proving to be an excellent stem cell transplantation carrier.
Protective role of selenium-binding protein 1 (SELENBP1) in patients with ulcerative colitis: Cross-sectional study
Authors: Fonseca-Camarillo Gabriela , Furuzawa-Carballeda Janette , Priego-Ranero Ángel Alexis , Barreto-Zúñiga Rafael , Martínez-Benítez Braulio , Yamamoto-Furusho Jesus K 
Published: February 2024

Abstract
Background
The expression of selenium-binding protein 1 (SELENBP1), a molecule responsible for the absorption of selenium in the colon, is crucial for its immunoregulatory effect, but this phenomenon has not been studied in patients with UC. The present study aimed to determine the clinical outcome of SELENBP1 expression in colonic tissue from patients with UC.
Methods and Results
The relative mRNA expression of SELENBP1 was analyzed in 34 patients with UC and 20 patients as controls. All the statistical analyses were performed with SPSS 19. SELENBP1 gene expression was significantly lower in patients with active UC than in patients with UC in remission (P = 0.003) and within the controls (P = 0.04). Overexpression of the SELENBP1 gene was associated with a more benign clinical course characterized by initial activity and more than two years of prolonged remission (P = 0.003, OR = 23.7) and an intermittent clinical course (P = 0.001, OR = 47.5), mild histological activity (P = 0.05 OR = 0.11, IC = 1.00-1.41) and severe histological activity (P = 0.02, OR = 0.08, 95% CI = 0.008–0.866). SELENBP1-positive cells were found mainly in the inflammatory infiltrate of the submucosa and internal layers muscular and adventitia from patients with active UC compared to those in the control group (p ≤ < 0.001).
Conclusions
The upregulation of SELENBP1 was associated with a benign clinical course of UC. This is the first report suggesting the immunoregulatory role of SELENBP1 in patients with UC.
Ethnic Disparities in Breast Cancer Patterns in Brazil: Examining Findings from Population-Based Registries
Authors: Silva Jessé Lopes da , de Albuquerque Lucas Zanetti , Rodrigues Mariana Espírito Santo , Thuler Luiz Claudio Santos , de Melo Andréia Cristina 
Published: February 2024

Abstract
Purpose: To investigate breast cancer (BC) incidence and mortality rates among specific racial groups in Brazil.
Methods: BC incidence was evaluated from 2010 to 2015, using Brazilian Population-Based Cancer Registries, incorporating age-standardized ratios and annual average percentage change (AAPC). Clinical and sociodemographic data from 2000 to 2019 were obtained from Hospital-Based Cancer Registries. Mortality data from 2000 to 2020 were sourced from the National Mortality Information System, comparing White women and Black women.
Results: Across 13 Brazilian registries, 70,896 new BC cases were reported from 2010 to 2015. The median BC incidence rate was notably higher for White women (101.3 per 100,000) compared to Black women (59.7 per 100,000). In the general population, non-significant decrease in annual BC incidence was observed (AAPC = -1.2; p = 0.474). Black women were more likely to live in underdeveloped areas, have lower education levels, live without a partner, and have higher alcohol consumption as compared to White women. A higher proportion of Black women received advanced-stage diagnoses (60.1% versus 50.6%, p < 0.001). BC-related mortality analysis showed 271,002 recorded deaths, with significant increase in BC-specific mortality rates in both racial groups. Black women displayed an AAPC of +2.3% (p < 0.001), while White women demonstrated a moderately elevated AAPC of +0.6% (p < 0.001).
Conclusion: This study underscores the need for targeted policies to address disparities in access to early detection and proper treatment, particularly for Black women in underprivileged regions, aiming to improve the survival rates of Brazilian women grappling with BC.
A Prediction of PM10 Air Contamination Using Multiple Linear Regression
Authors: Kumar Lokesh , Kumar Gaurav 
Published: February 2024

Abstract
Sufficient assessment of air contaminants, mainly Particulate Matter, is necessary for effective and persuasive management of air quality. Numerous elements influence PM prediction, therefore it is essential to incorporate the most appropriate input variables to provide the most dependable forecasts. This work used the multiple linear regression technique to select the most appropriate variables for the model. The concentration of PM10 in this work is determined by measuring the amounts of nitrogen dioxide (NO2), air quality index (AQI), and sulfur dioxide (SO2).
Robotic Sorting of Zebrafish Embryos
Authors: Diouf Alioune , Sadak Ferhat , Gerena Edison , Mannioui Abdelkrim , Zizioli Daniela , Fassi Irene , Boudaoud Mokrane , Legnani Giovanni , Haliyo Sinan 
Published: February 2024

Abstract

Transcriptomics and metabolomics, two biological research fields that need large numbers of zebrafish embryos, require the removal of unfertilized or nonviable zebrafish embryos. Biologists routinely conduct the tedious, error-prone, and time-consuming manual sorting of embryos. We suggest a novel approach that combines deep learning and microfluidics for automated sorting to overcome this difficulty. To determine the developmental stage and viability of zebrafish eggs, we trained an optimized YOLOv5 model with 95.8% accuracy and a processing speed of 10.6 ms per frame, classifying them as dead, unfertilized, or alive. The eggs are contained in traps on a microfluidic chip using micro-pumps. After that, the deep learning system can identify and automatically sort the eggs according to their viability by positioning this chip on an XYZ motorized stage. The sorting experiment was conducted in two modes: without feedback and with feedback while using the dead egg position. The first one had a sorting success rate of 90% as opposed to 97.9% for the feedback mode with 3 seconds required for each dead egg. This automated approach provides a precise and efficient way to handle a large number of zebrafish embryos while also greatly reducing the work-load associated with manual sorting. The success rates attained demonstrate the usefulness and effectiveness of our suggested methodology, opening new avenues for biological research involving accurate embryo selection.
Hemospray® (Hemostatic powder TC-325) as monotherapy for acute gastrointestinal bleeding: a multi-center prospective study
Authors: Papaefthymiou Apostolis , Aslam Nasar , Hussein Mohamed , Alzoubaidi Durayd , Gross Seth A , Serna Alvaro De La , Varbobitis Ioannis , Hengehold Tricia A. , López Miguel Fraile , Fernández-Sordo Jacobo Ortiz , Rey Johannes W. , Hayee Bu , Despott Edward J. , Murino Alberto , Moreea Sulleman , Boger Phil , Dunn Jason M. , Mainie Inder , Mullady Daniel , Early Dayna , Latorre Melissa , Ragunath Krish , Anderson John T. , Bhandari Pradeep , Goetz Martin , Kiesslich Ralf , Coron Emmanuel , De Santiago Enrique Rodríguez , Gonda Tamas A. , O'Donnell Michael , Norton Benjamin , Telese Andrea , Simons-Linares Roberto , Haidry Rehan J 
Published: February 2024

Abstract
Background
Topical hemostatic powders are a reliable second-line approach in acute gastrointestinal (GI) bleeding (AGIB) treatment, according to the existing guidelines. Increasing evidence supports the use of hemostatic powder TC-325 (Hemospray®) as monotherapy in specific GI bleeding scenarios. This prospective, multi-center study evaluated the performance of TC-325 as monotherapy for GI hemorrhage.
Methods
Eighteen centres across Europe, and USA contributed between 2016 and 2022 to an international multicentre prospective registry. Adults with AGIB were eligible (melena, hematemesis, hematochezia, Glasgow-Blatchford score ≥ 1 or abnormal Oakland score), unless TC-325 was part of combined hemostasis (adjunctive to clips or thermocautery). The primary endpoint was immediate haemostasis. Secondary outcomes were rebleeding, 7- and 30-day mortality rates. Potential associations with risk factors were investigated with statistical significance set for p ≤ 0.05.
Results
One hundred and ninety patients were included (age range = 51–81, male:female = 2:1). Peptic ulcer (n = 48), upper GI malignancy (n = 79), post endoscopic treatment-related hemorrhage (n = 37), and lower GI lesions (n = 26) were diagnosed. The primary outcome was recorded in 96.3% (95%CI:92.6–98.5) with rebleeding in 17.4% (95%CI:11.9–24.1) when TC-325 was used as primary monotherapy. Post-hemostasis, 9.9% (95%CI:5.8–15.6) died within 7 days and 21.7% (95%CI:15.6–28.9) within 30 days. Regarding peptic ulcer, the immediate hemostasis was achieved in 88% (95%CI:75–95) and 26% (95%CI:13–43) rebled. Increased American Society of Anaesthesiologists (ASA) score was associated with mortality [OR:23.5 (95%CI:1.60–345); p = 0.02]. The primary outcome was achieved in 100% of cases with malignancy and post GI intervention bleeding, with rebleeding in 17% and 3.1%, respectively. Twenty-six patients received Hemospray® for lower GI bleeding, and in all but one the primary outcome was achieved.
Conclusions
TC-325 powder as monotherapy represents a safe and effective modality especially in malignancy- or post-endoscopic intervention-related bleeding. In peptic ulcer bleeding it could be helpful when the standard of care treatment is not feasible or unavailable, to stabilise patients.
Association between High-Density Lipoproteins (HDLs) and Prostate Specific Antigen (PSA): a cross-sectional study from NHANES database
Authors: Adan Mohamed Mohamoud , Hu Bowen , Yan Minbo Yan , Li Gonghui , Hidig Sakarie Mustafe 
Published: February 2024

Abstract
Background:
According to growing evidence, high-density lipoproteins (HDLs ) may raise PSA levels in the prostate. The link between HDL-C and PSA, on the other hand, is debatable and challenging. Hence, this research examined the relationship between HDL-C and PSA in men using the National Health and Nutrition Examination Survey (NHANES) database.
Methods:
We extracted NHANES data for five cycles from 2001 to 2010. The data used for analysis included PSA concentrations, sociodemographic data, and laboratory data. After the screening, 6,669 of 52,195 participants were included in the study. Participants were divided into 4 groups based on HDL-C quartiles. We analyzed categorical and continuous variables using weighted chi-square tests and linear regression models to compare differences between groups. We constructed 3 weighted multivariate linear regression models and assessed the association between HDL-C and PSA using a smoothed curve fit.
Results:
In our study, unadjusted and adjusted multivariate linear regression models revealed a significant positive association between prostate-specific antigen (PSA) concentrations and serum high-density lipoprotein cholesterol (HDL-C) levels. Specifically, each unit increase in HDL-C ratio was associated with an increase in PSA concentration by 0.470 ng/mL (P < 0.001) in the unadjusted model. In minimally adjusted models, accounting for socioeconomic and demographic factors, this correlation remained significant, with an increase of 0.408 ng/mL per unit increase in serum HDL-C (P < 0.001). Furthermore, the stratified analysis revealed various impacts based on socioeconomic status and HDL-C levels, with a significant interaction between household income and HDL-C levels (P = 0.037). Exclusion of subjects with low HDL-C levels strengthened the association, showing a significant increase in PSA concentration with higher HDL-C levels (0.50 ng/mL per 1 mmol/L increase, P = 0.009). Our findings suggest a nuanced relationship between HDL-C levels, socioeconomic factors, and PSA concentrations, highlighting the potential importance of considering these factors in prostate cancer screening and risk assessment.
Conclusion:
This study found a positive association between serum HDL-C and PSA concentrations in adult men in the United States without a prostate cancer diagnosis. Moreover, People with low HDL-C are more likely to be diagnosed with prostate cancer in the late stage of the disease. Hence, people with high levels of HDL-C should be tested for PSA to help early detection of prostate cancer.
UDC Image Restoration via Lightweight Dual-Domain Network
Authors: Zheng Zhuoran , Wang Di , Jia Xiuyi 
Published: February 2024

Abstract
With the development of full-screen devices, smartphone manufacturers have started to explore placing the camera behind the screen, offering larger display-to-body ratios. However, this under-display camera (UDC) imaging system causes varying degrees of degradation for captured RGB images. To address this issue, we propose a lightweight dual-domain network (LD2Net) for restoring UDC images. Specifically, first, the UDC image is decomposed into reflection and illumination images. Then, an amplitude-phase mutual guided block is designed to reconstruct the reflection image in the frequency domain and restore the attenuated highfrequency components. Meanwhile, we employ a multi-scale hybrid dilated convolution block to reconstruct the degeneracy of UDC images in the spatial domain. Finally, the feature maps of the spatial and frequency domain outputs are fused to recover a clear image. In addition, we propose a global perceptual loss function based on the Transformer framework to help LD2Net reconstruct clearer textures and colors. Extensive experiments show that our model can achieve superior results with relatively few parameters. The valid URL for our code is at https://github.com/zzr-idam/LD2Net.