bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Efficacy of Atezolizumab/Bevacizumab in unresectable Hepatocellular Carcinoma - a multicentric study
Authors: Babu Merin , Komaranchath Ashok Sebastian , Valsan Arun , Warrier Arun R , Rakesh M P , Jose Wesley M , Haridas Nikhil K , Soman Sumi , Nair Manjima P , Sadasivan Shine , Menon Abhinav , Thabrez Mohammed , Pavithran Keechilat 
Published: January 2025

Abstract

Purpose: Immunotherapy with atezolizumab and bevacizumab is the current first-line standard of care for unresectable hepatocellular carcinoma (HCC). This study aimed to evaluate the safety and efficacy profile of atezolizumab-bevacizumab in our Indian population, as there are limited studies.
Patients and methods: All patients diagnosed with advanced HCC who received systemic therapy with atezolizumab bevacizumab as the first- or second-line therapy were included in the study. Data were collected retrospectively from two comprehensive cancer centres between September 2020 and May 2024 by accessing the medical records. As per the IMBrave 150 trial, patients were given atezolizumab 1200 mg and bevacizumab 15 mg/kg intravenously every 3 weeks. Demographic details, adverse events, and radiological data were collected.
Results: We included one hundred and four patients with a median age of 67 years. Majority of the patients had a compensated cirrhosis (n = 77; 74%), while Child Pugh class B cirrhosis was observed in 19 patients (18%), and class C cirrhosis in 3 patients (3%). The median OS was 14.8 (95% CI; 6.8 – 22.9) months and median PFS in the whole cohort was 6.2 months (95% CI; 2.5 – 9.9) months.
Conclusion: The real-world OS and PFS rates were lower than those of the IMBrave trial, most likely because 43% of our patients did not meet the inclusion criteria. We conclude that the combination of atezolizumab and bevacizumab is a safe and effective option for patients with unresectable hepatocellular carcinoma patients with manageable toxicities.
Trends in socio-economic level and accessibility to healthcare of households in Eastern Democratic Republic of Congo from 2011 to 2023: Documentary review of South Kivu
Authors: Mugisa Anicet , Bigirinama Rosine , Kisembo Claude , Mulume Armand , Lurhangire Emmanuel , Bisimwa Ghislain , Hermans Michel P , Mwene-batu Pacifique 
Published: January 2025

Abstract

Background
In the Democratic Republic of Congo (DRC), the population's standard of living has deteriorated over the years as a result of the country's worsening socio-economic, security and political context. The aim of this study was to assess changes in the socio-economic level and accessibility to healthcare in health zones of South Kivu province between 2011 and 2023.
Methods
A literature review was carried out on changes in the socio-economic level of households in the province of South Kivu and access to healthcare from 2011 to 2023. The search was carried out in the PubMed and Google Scholar databases and on non-governmental organizations (NGO) websites, using keywords relating to socio-economic level and access to healthcare in South Kivu and the DRC.
Results
A total of 11 documents were selected out of 74 consulted for thematic analysis. Data from South Kivu show various changes in households. The proportion of female heads of household increased from 14% in 2011 to 43.8% in 2023. Illiteracy among household heads fell slightly, reaching 23% in 2023. Mean household size increased from 6.8 to 10 persons. Mean monthly income fell from USD 190 to 67 between 2013–2014 and 2023. The number of episodes of illness per household also increased, from 1.1 in 2011 to 2.3 in 2023. Despite a majority of households living less than 30 minutes from a healthcare facility, self-medication and sale of assets to cover healthcare costs became more common.
Conclusion
The socio-economic situation in South Kivu is deteriorating, with falling income and the majority of the population living below poverty line, impacting access to health services in spite of favourable regional access. The number of female heads of household likely increased partly as a result of armed conflicts conducing to death or physical disability of spouses. In terms of water, hygiene and sanitation (WASH), improved access to drinking water was offset by unhygienic latrines and food security challenges. Targeted action is needed to improve access to basic services and promote sustainable development with a view to achieving universal health coverage in the DRC.
HDAC8-mediated CAPZB desuccinylation enhances cytoskeleton remodeling to promote idiopathic pulmonary fibrosis
Authors: Liu Bo , Kang Di , Zhang Jinjin , Wang Yujie , Li Rongrong , Lv Changjun , Zhai Nailiang , Song Xiaodong , Zhang Songzi , Li Hongbo 
Published: January 2025

Abstract

Background
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia of unknown etiology. Abnormal regulation of the cytoskeleton is a key factor driving pulmonary fibrogenesis. However, the molecular mechanisms of cytoskeleton remodeling in pulmonary fibrosis remains obscure.
Methods
Succinylome analysis of lung tissues from bleomycin (BLM)-treated mice was performed. Key modified proteins and sites were identified through Clusters of Orthologous Groups (COG) functional classification statistics and liquid chromatograph-mass spectrometer (LC-MS/MS) analysis. F-actin-capping protein subunit beta (CAPZB) was selected for further investigation. Gain- and loss-of-function and modified site mutation studies were conducted to assess the function of CAPZB in pulmonary fibrosis and the effect of succinylation on it. Then, Co-immunoprecipitation (Co-IP) and functional studies were used to identify the desuccinylase for CAPZB. Finally, adenoviral vectors were constructed to evaluate the effect of CAPZB on pulmonary fibrosis in vivo.
Results
A total of 910 lysine succinylation sites in 388 proteins were differentially expressed between the BLM-treated mice and the sham group. COG functional classification statistics showed that 42 proteins were classified into cytoskeleton-related proteins. Among these proteins, the succinylation level of CAPZB was significantly decreased. And lysine57 (K57), lysine95 (K95), and lysine235 (K235) were identified as the desuccinylation sites of CAPZB in pulmonary fibrosis. Gain- and loss-of-function studies revealed that CAPZB restrained cytoskeletal remodeling to inhibit pulmonary fibrogenesis. The effect of succinylation modification on CAPZB function revealed that CAPZB desuccinylation inhibited its capping function on the barbed end of F-actin, resulting in promote fibroblast proliferation, migration, and differentiation. Further, histone deacetylase enzymes (HDACs) inhibitors and Co-IP demonstrated that HDAC8 is the desuccinylase for CAPZB in pulmonary fibrosis. Overexpressed HDAC8 desuccinylated CAPZB, led to abnormal F-actin polymerization and promoted pulmonary fibrosis. Finally, the therapeutic effect of succinylated CAPZB was confirmed in mice.
Conclusions
Collectively, our research revealed that HDAC8-mediated CAPZB desuccinylation promoted idiopathic pulmonary fibrosis by enhancing cytoskeleton remodeling, suggesting that desuccinylated CAPZB could be a potential therapeutic target related to cytoskeleton remodeling for pulmonary fibrosis.
Research on mechanical part recognition method based on improved mask R-CNN instance segmentation
Authors: Xiao Kui , Wang Lei , Xu Haoran , Zhang Pengchao , Zhang Heng 
Published: January 2025

Aiming at the problem of poor part recognition due to mutual occlusion between parts and the influence of different postures in the assembly scene, we propose an improved Mask R-CNN-based part recognition method for complex scenes. Firstly, the ResNet101 network is used to enhance the feature extraction capability of the network and improve the part recognition effect; secondly, the normalization layer of the backbone network is replaced to reduce the effect of batch size on the feature extraction of the model; lastly, the feature pyramid network structure is improved to enhance the transfer efficiency between the high and low layers of the network, and to enhance the capability of the feature capture; through the experiments on the homemade dataset, the average detection accuracy of this method is 4.7 % higher than that of the original Mask R-CNN. Through the experiments on the homemade dataset, it is found that compared with the original Mask R-CNN, the average detection accuracy of the method is improved by 4.7 %.The optimized network model proposed in this paper can improve the accuracy of part recognition, realize the accurate detection of parts in the complex environment such as stacking, occlusion and so on, and provide a solution for the recognition of parts in the complex environment.
Modulation of in vitro Network Activity by Optogenetic Stimulation of
Parvalbumin-positive Interneurons During Estrous Cycle
Authors: Li Fei Ran , Lévesque Maxime , Wang Siyan , Gemayel Mia , Avoli Massimo 
Published: January 2025

Background:
Catamenial epilepsy, which is defined as a periodicity of seizure exacerbation
occurring during the menstrual cycle, has been reported in up to 70% of epileptic women. These
seizures are often non-responsive to medication and our understanding of the relation between menstrual
cycle and seizure generation (i.e. ictogenesis) remains limited.

Methods:
Here, we employed the in vitro 4-aminopyridine model of epileptiform synchronization, to
analyze the effects induced by optogenetic activation of parvalbumin (PV)-positive interneurons at 8
Hz during estrous and non-estrous phases in female PV-ChR2 mice.

Results:
We found that: (i) optogenetic stimulation of PV-positive interneurons induced an initial interictal
spike followed by field oscillations occurring more often in estrous (59%) than in non-estrous
slices (17%); (ii) these oscillations showed significantly higher power in estrous compared to nonestrous
slices (p < 0.001); (iii) significantly higher rates of interictal spikes and ictal discharges were
identified in both estrous and non-estrous slices during optogenetic stimulation of PV-positive interneurons
compared to periods of no stimulation (p < 0.05); and (iv) ictal events appeared to occur
more frequently during optogenetic stimulation in estrous compared to non-estrous slices.

Conclusion:
Our findings show that optogenetic activation of PV-interneurons leads to more powerful
network oscillations and more frequent ictal discharges in estrous than in non-estrous slices. We
conclude that during the rodent estrous cycle, PV-interneuron hyperexcitability may play a role in
epileptiform synchronization and thus in catamenial seizures.
The Early Pharmacological Strategy with Inodilator, bEta-blockers,
Mineralocorticoid Receptor Antagonists, Sodium-glucose coTransporter-2
Inhibitors and Angiotensin Receptor-neprylisin Inhibitors in Acute Heart
Failure (PENTA-HF)
Authors: Severino Paolo , D'Amato Andrea , Prosperi Silvia , Mariani Marco Valerio , Cestiè Claudia , Myftari Vincenzo , Labbro Francia Aurora , Marek-Iannucci Stefanie , Manzi Giovanna , Filomena Domenico , Maestrini Viviana , Mancone Massimo , Badagliacca Roberto , Vizza Carmine Dario , Fedele Francesco 
Published: January 2025

Purpose:
The management of acute heart failure (AHF) is crucial and challenging. Regarding
the use of inotropes, correct patient selection and time of administration are of the essence.
We hypothesize that the early use of Levosimendan favouring hemodynamic stabilization and enables
rapid optimization of guideline-directed medical therapy (GDMT) in patients with HF, eventually
impacting the patient’s prognosis during the vulnerable phase.

Methods:
This prospective, observational study enrolled consecutive patients admitted due to AHF.
Propensity score matching (PSM) analysis has been used to homogenize differences between groups.
In group 1 (G1), patients were treated with early 24-h Levosimendan infusion followed by in-hospital
introduction/up-titration of GDMT. In group 2 (G2), patients were treated with alternative inotropes/
vasopressors followed by in-hospital introduction/up-titration of GDMT. The comparison
between the two groups has been performed at the 6-month follow-up in terms of cardiovascular
(CV) mortality and HF hospitalizations (HFH).

Results:
233 patients were included in the present study, and after propensity match adjustments, 176
patients were analysed, 88 patients for each group. No differences in the baseline characteristics have
been reported between the groups. At 6 months follow-up, no statistically significant differences were
shown in terms of the composite endpoint of CV death and HFH (p = 0.445) and CV death (p = 0.62).
Statistically significant differences between the two groups were reported in terms of HFH (p = 0.02).
The Kaplan-Meier survival analysis showed that patients in G1 were significantly less hospitalized
compared to G2 during the 6 months after the index hospitalization (log-rank p = 0.03).

Conclusions:
Early 24-hour infusion of Levosimendan followed by rapid optimization of HF diseasemodifying
therapies results in a significant reduction of HFH in the vulnerable post-discharge phase.
Assessment of Biochemical Markers of Bone Turnover and their Association in Iraqi Thalassemia Patients
Authors: Alhani Zainab , Bouaziz ‪Mohamed 
Published: January 2025

Background:
Thalassemia syndromes are heterogeneous groups of inherited anemia.
Managing these conditions often requires regular blood transfusions, which can lead to complications,
such as iron overload and bone disorders. This study aimed to examine the biochemical markers
of bone turnover in thalassemia patients and investigate their associations in the Iraqi cohort.

Method:
The study involved 45 thalassemia patients and 45 healthy control subjects. Fibroblast
growth factor 23 (FGF-23), phosphorus, vitamin D, vitamin K, matrix Gla protein (MGP), and parathyroid
hormone (PTH) were measured by ELISA kit, and the level of calcium ion was determined
by atomic absorption spectrometry technique.

Results:
The results demonstrated that the levels of FGF-23 and phosphorus were considerably higher
in patients with thalassemia than in control (p=0.0001**). Conversely, the levels of vitamin D
(p=0.005**), vitamin K (p=0.0002**), MGP (p=0.0003**), and PTH (p=0.0001**) were significantly
lower in thalassemia patients compared to control subjects. Furthermore, no significant difference
in calcium levels between the two groups (p-value = 0.465) was observed. The association of bone
biochemical markers demonstrated that FGF-23 has a positive significant correlation with phosphorous
and is inversely correlated with vitamin D, PTH, vitamin K, and MGP. Moreover, PTH has a
positive significant correlation with vitamin D, vitamin K, and MGP. However, it has a significant
negative correlation with PTH and phosphorous.

Conclusion:
These findings show that patients with thalassemia display biochemical markers associated
with bone and cardiovascular disorders, indicating the need for specialized medical treatments
for this patient population.
Brand Love, Perceived Quality Dan Social Media Marketing Terhadap Repurchase Intention
Authors: Akmal Zetia Azzahra , Prabandari Sri Palupi 
Published: January 2025

This research aims to identify the influences of brand love, perceived quality, and social media marketing on repurchase intention to Adidas products. This quantitative explanatory study uses non- probability sampling method and purposive sampling technique, resulting in 120 respondents with the characteristics of woman working in the Special Capital Region of Jakarta who have purchased Adidas products at least twice. The data was harvested from questionnaires and was analyzed in IBM SPSS version 26. This study finds that brand love, perceived quality, and social media marketing have positive and significant effects on repurchase intention.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh brand love, perceived quality, social media marketing terhadap repurchaseintention pada produk Adidas. Penelitian ini menggunakan jenis penelitian eksplanatori dengan metode kuantitaif. Teknik sampling yang digunakan non-probability sampling dengan metode purposive kepada 120 responden. Karakteristik dari responden merupakan Wanita yang bekerja di DKI Jakarta dengan minimal pembelian ulang produk Adidas sebanyak dua kali. Data hasil penyebaran kuesioner pada penelitian ini kemudian dianalisis dengan menggunakan IBM SPSS Versi 26. Hasil pada penelitian ini adalah variabel brand love, perceived quality, social media marketing berpengaruh positif dan signifikan terhadap repurchase intention.
Upaya penanggulangan kejahatan jalanan klitih oleh Kepolisian Resor Sleman
Authors: Fadilah Muhammad Rafi , Hartini Sri 
Published: January 2025

ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan upaya penanggulangan kejahatan jalanan klitih oleh Polres Sleman, hambatan dalam penanggulangan kejahatan jalanan klitih, dan upaya mengatasi hambatan tersebut. Penelitian ini merupakan penelitian deskriptif kualitatif. Teknik pengumpulan data menggunakan wawancara dan dokumentasi. Subjek penelitian ditentukan secara purposive, meliputi: Kasat Binmas, Banit Tibsos Sat Binmas, Kasat Sampata, Penyidik Pembantu Unit Jatanras, dan Kanit Jatanras. Teknik pengumpulan data adalah wawancara dan dokumentasi. Teknik pemeriksaan keabsahan data dilakukan dengan teknik cross check. Analisis data secara induktif. Hasil penelitian menunjukkan bahwa terdapat upaya oleh Polres Sleman dalam menanggulangi kejahatan jalanan klitih melalui upaya preemtif, preventif, dan represif. Upaya preemtif melalui kegiatan sambang, pembinaan dan penyuluhan, pembinaan karakter, profiling, dan koordinasi dengan instansi terkait. Upaya preventif dengan melaksanakan kegiatan patroli dan razia. Upaya represif dilakukan dengan tindakan penyelidikan dan penyidikan. Hambatan preemtif yaitu keterbatasan anggaran, jadwal berbenturan, dan antusias peserta didik kurang. Hambatan preventif yaitu personel terbatas, wilayah Sleman sangat luas, dan pelaku mengetahui titik patroli. Hambatan represif berkaitan dengan minimnya saksi dan kesulitan terhadap bukti. Adapun upaya mengatasi secara preemtif dengan meminimalisir anggaran, koordinasi pelaksanaan sosialisasi, dan pemberian materi secara ringan dan humanis. Upaya mengatasi hambatan preventif dengan pengajuan penambahan personel, memaksimalkan patroli dan koordinasi polsek, serta koordinasi fungsi intelijen. Upaya mengatasi hambatan represif dengan mengungkap kasus secara maksimal dan meningkatkan profesionalitas anggota.
Implementasi Kebijakan Pendidikan Antikorupsi melalui Mata Pelajaran Pendidikan Pancasila dan Kewarganegaraan di SMP Negeri 1 Dlingo
Authors: Sunarwi Sunarwi , Hayati Iffah Nur 
Published: January 2025

ABSTRAKArtikel ini ditulis berdasarkan penelitian yang bertujuan untuk mendeskripsikan pelaksanaan kebijakan Pendidikan Antikorupsi melalui Mata Pelajaran Pendidikan Pancasila dan Kewarganegaraan di SMP Negeri 1 Dlingo serta faktor penghambat dan faktor pendukung dalam pelaksanaan kebijakan tersebut. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Subjek penelitian ditentukan dengan menggunakan teknik purposive. Pengumpulan data menggunakan teknik wawancara dan dokumentasi. Analisis keabsahan data dilakukan menggunakan teknik cross check. Analisis data dilakukan secara induktif dengan menggunakan model Miles dan Huberman. Hasil penelitian menunjukkan bahwa: (1) kebijakan Insersi Pendidikan Antikorupsi di SMP Negeri 1 Dlingo dilaksanakan dengan tahap yaitu: (a) penyisipan muatan Pendidikan Antikorupsi ke dalam kurikulum, (b) koordinasi, (c) pelaksanaan program, dan (d) pengawasan. Pelaksanaan kebijakan ini belum optimal ditunjukkan dengan adanya komunikasi yang kurang konsisten, belum meratanya sarana dan prasarana penunjang proses pembelajaran, belum adanya kerja sama dengan pihak lain yang terkait, tidak adanya pembiayaan khusus, serta tidak adanya struktur organisasi dan standar operasional prosedur; (2) faktor penghambat pelaksanaan kebijakan Insersi Pendidikan Antikorupsi yaitu komunikasi pasif dari pihak orang tua, sumber daya yang terbatas, dan rendahnya komitmen guru. Sedangkan faktor pendukung pelaksanaan kebijakan Insersi Pendidikan Antikorupsi yaitu adanya media komunikasi dan komitmen pimpinan sekolah.
Hak Dan Kewajiban Siswa Berkebutuhan Khusus Dalam Pelaksanaan Pendidikan Inklusi Sebagai Pendidikan Nondiskriminasi Di MAN 2 Sleman
Authors: Samchati Anis , Suyato Suyato 
Published: January 2025

ABSTRAKPenelitian ini bertujuan untuk: 1) Menjelaskan perspektif siswa berkebutuhan khusus terkait pelaksanaan pendidikan inklusi sebagai pendidikan nondiskriminasi; 2) Mendeskripsikan hak dan kewajiban siswa berkebutuhan khusus sudah terpenuhi dengan baik atau masih terdapat kekurangan. Penelitian ini menggunakan jenis penelitian deskriptif dengan pendekatan kualitatif. Penentuan subjek penelitian menggunakan teknik purposive, yang kemudian didapatkan subjek penelitian yaitu empat siswa berkebutuhan khusus MAN 2 Sleman, dan tiga sahabat inklusi MAN 2 Sleman. Teknik pengumpulan data menggunakan wawancara dan dokumentasi. Teknik pemeriksaan keabsahan data dilakukan menggunakan cross check. Teknik analisis data melalui reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa: 1) Pelaksanaan pendidikan inklusi sebagai pendidikan nondiskriminasi di MAN 2 Sleman sudah terlaksana dengan baik. Hal ini dibuktian dengan jarang terjadinya tindakan diskriminasi kepada siswa berkebutuhan khusus di MAN 2 Sleman, warga sekolah saling membantu satu sama lain. 2) Hak dan kewajiban siswa berkebutuhan khusus di MAN 2 Sleman sudah terpenuhi. Hak siswa berkebutuhan khusus di MAN 2 Sleman yaitu mendapatan pendidikan agama sesuai dengan agama yang dianutnya, mendapatkan pelayanan pendidikan sesuai dengan bakat, minat dan kemampuannya, memperoleh bantuan fasilitas belajar, beasiswa atau bantuan lainnya, dan diterima di sekolah umum atau kejuruan. Kewajiban siswa berkebutuhan khusus MAN 2 Sleman yaitu menjalankan ibadah sesuai agama yang dianutnya, mengikuti proses pembelajaran sesuai dengan peraturan yang berlau di sekolah, menaati peraturan yang berlau di sekolah. Akan tetapi untuk kewajibannya masih belum terpenuhi sepenuhnya karena terdapat kendala seperti jarak tempat tinggal dengan sekolah yang jauh dan terbatasnya transportasi sehingga menyebabkan siswa berkebutuhan khusus sering terlambat sekolah.
Implementasi Penilaian dalam Pembelajaran Pendidikan Pancasila dan Kewarganegaraan Berbasis Daring di Mts 8 Gunungkidul.
Authors: Jaya Prabawati Sukma , Hayati Iffah Nur 
Published: January 2025

Tujuan dari penelitian ini untuk: (1) mendeskripsikan implementasi penilaian dalam pembelajaran PPKn berbasis daring di MTs Negeri 8 Gunungkidul, (2) mengidentifikasi hambatan yang dihadapi guru dalam melaksanakan pembelajaran PPKn berbasis daring di MTs Negeri 8 Gunungkidul, (3) mendeskripsikan upaya yang dilakukan guru untuk mengatasi adanya hambatan dalam melaksanakan penilaian dalam pembelajaran PPKn berbasis daring di MTs Negeri 8 Gunungkidul. Penelitian ini menggunakan pendekatan kualitatif. Subjek ditentukan melalui teknik purposive, yakni guru PPKn. Pengujian keabsahan data menggunakan teknik cross chek. Analisis data dengan menggunakan induktif. Hasil penelitian menunjukan: (1) Pelaksanaan penilaian pembelajaran PPKn berbasis daring yang dilakukan belum terlaksana sesuai dengan standar penilaian pembelajaran yang telah ditetapkan; (2) Hambatan yang di alami yakni, keterbatasan guru dalam mengembangkan platform pembelajaran, guru merasa kesulitan dalam melakukan kontrol kepada peserta didik, keterbatasan waktu dalam melakukan penilaian dan koneksi internet yang tidak lancar; (3) Upaya yang dengan memaksimalkan platform pembelajaran, memperbanyak interaksi dengan peserta didik, dan mengikuti pelatihan/diklat.