bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF PROFESSIONAL COMPETENCIES AND JOB SATISFACTION OF LIBRARIANS IN PRIVATE UNIVERSITIES IN SOUTH-WEST, NIGERIA
Authors: Oguntayo S. A. , Unegbu V. E. , Alegbeleye, G. O. 
Published: February 2024

The study analyzed the professional competencies and job satisfaction of librarians in private university libraries in South-West, Nigeria. A survey research design was used for the study. The participants in this study were two hundred and forty-three (243) librarians from thirty-three private universities in Nigeria's South-West. Total enumeration was used to cover the two hundred and forty-three (243) librarians working in the thirty-three under study. The researcher adopted the instrumentation of the questionnaire method from Yaya (2019) for the collection of data on job satisfaction.The response rate was 61.7%. Descriptive statistics of frequency, percentage, mean and standard deviation were used to analyze the research question. Findings revealed that librarians in private university libraries in South-West, Nigeria experienced a high level of job satisfaction in overall relationship with fellow workers, carrying support from colleagues, information sharing and team spirit among colleagues. Despite high level of librarians’ job satisfaction; there was low satisfaction in the areas of salary and job security. Therefore, it is recommended that the management of private universities in the study areas improve satisfaction in these low areas. The librarians in the private university libraries in South-West, Nigeria possessed professional competence on the job. Professional competence was measured with three dimensions namely traits, knowledge and self-concept The study recommended that academic librarians’ professional competence on the job must be sustained.
Response of Different Levels of Boron Fertilizer on Growth and Yield of Okra (Abelmoschus esculentus L.)
Authors: Sharmin Shaila , Kafi Abdullah Al , Arfin Md Nazmul Hasan , Miah Md Shohidullah 
Published: February 2024

The study was carried out at the Agricultural Research Field of IUBAT to investigate the impact of varying levels of boron (B) fertilizer on the growth and production of okra (Hybrid Okra-Shomy). The experiment followed a Randomized Complete Block Design (RCBD) with four replications. The experiment included four treatments: T0 (Control), T1 (1kg B ha-1), T2 (2kg B ha-1), and T3 (3kg B ha-1). These treatments were implemented in order to assess the optimal outcomes of the study. The findings of the study showed that T2 (2kgB/hac) treatment performed better in all aspects of growing parameter especially yield contributing traits like number of fruit/plant (89.75), number of fruit/treatment (387.98), individual fruit weight (17.34gm), number of seed/fruit (57.50),100 seed weight (8.15gm), yield/plant (387.98gm), yield/hac (1549.7kg), yield (17.09) ton/hac, Plant fresh weight/plant (524.81gm) and root length (20.40cm), respectively.
IUBAT Review, 6(2): 106-114
Experimental Validation a Method for Assessing Neutralizing Antibodies of Romiplostim in Human Plasma
Authors: Afanaseva A. N. , Saparova V. B. , Makarenko I. E. , Selmenskikh T. A. , Kurkin D. V. , Hohlov A. L. , Drai R. V. 
Published: February 2024

Introduction. Romiplostim is an analogue of the fusion protein peptide of thrombopoietin (TPO), which increases platelet count by binding and activating the human thrombopoietin receptor (TPO-R). It is used to treat thrombocytopenia associated with chronic immune thrombocytopenia. For romiplostim, one of the possible adverse reactions from the immune system is immunogenicity: the production of anti-drug antibodies to the medicinal product, including neutralising antibodies, which may affect the efficacy and safety profile of the medicinal product.Aim. Validate the procedure for determining neutralising antibodies to romiplostim in human plasma for further clinical studies of immunogenicity.Materials and methods. The study used rabbit polyclonal antibodies to romiplostim, Nplate® produced by Amgen Europe as a standard sample; a placebo produced by LLC "GEROPHARM", a cell line 32D-hTPOR clone 63 with stable expression of human TPO receptor and a chemiluminescence assay kit CellTiter-Glo® Luminescent Cell Viability Assay produced by Promega to assess specificity. The experiment was carried out on cell line 32D-hTPOR clone 63, which was seeded on the first day and the neutralizing antibody concentrations were titrated with a constant concentration of romiplostim, then the chemiluminescence was detected on the second day. Statistical processing of the results was carried out using Prism 9 software.Result and discussion. The specificity of the procedure was demonstrated; at maximum concentration, the medicinal product differs from placebo by 309 times in the residual level of cell viability. The linearity of the procedure in terms of the coefficient determination is 0.9969. The precision of the procedure was determined: the repeatability was 1–9 %, the intermediate precision was 3–18 %. The coefficient of variation in selectivity of the procedure was 22 %. For the accuracy parameter, the values for recovery/spike were determined as 90–101 %. It was proven that there was no matrix effect.Conclusion. It can be stated that the procedure is linear, specific, highly precise, correct, selective and with a proven absence of matrix effect, which allows it to be used to determine the immunogenicity of romiplostim medicinal products in clinical studies.
Whole leg compression garments influence lower limb kinematics and associated muscle synergies during running
Authors: Yang Chenhao , Yang Yang , Xu Yongxin , Zhang Zhenyuan , Lake Mark , Fu Weijie 
Published: February 2024

The utilization of compression garments (CGs) has demonstrated the potential to improve athletic performance; however, the specific mechanisms underlying this enhancement remain a subject of further investigation. This study aimed to examine the impact of CGs on running mechanics and muscle synergies from a neuromuscular control perspective. Twelve adult males ran on a treadmill at 12 km/h, while data pertaining to lower limb kinematics, kinetics, and electromyography were collected under two clothing conditions: whole leg compression garments and control. The Non-negative matrix factorization algorithm was employed to extract muscle synergy during running, subsequently followed by cluster analysis and correlation analysis. The findings revealed that the CGs increased knee extension and reduced hip flexion at foot strike compared with the control condition. Moreover, CGs were found to enhance stance-phase peak knee extension, while diminishing hip flexion and maximal hip extension during the stance-phase, and the ankle kinematics remained unaltered. We extracted and classified six synergies (SYN1-6) during running and found that only five SYNs were observed after wearing CGs. CGs altered the structure of the synergies and changed muscle activation weights and durations. The current study is the first to apply muscle synergy to discuss the effect of CGs on running biomechanics. Our findings provide neuromuscular evidence for the idea of previous studies that CGs alter the coordination of muscle groups, thereby affecting kinematic characteristics during running.
Identification of inflammation-related biomarkers in keloids
Authors: Wang Xiaochuan , Wang Xiaoyang , Liu Zhenzhong , Liu Lei , Zhang Jixun , Jiang Duyin , Huang Guobao 
Published: February 2024

BackgroundThe relationship between inflammation-related genes (IRGs) and keloid disease (KD) is currently unclear. The aim of this study was to identify a new set of inflammation-related biomarkers in KD.MethodsGSE145725 and GSE7890 datasets were used in this study. A list of 3026 IRGs was obtained from the Molecular Signatures Database. Differentially expressed inflammation-related genes (DEGs) were obtained by taking the intersection of DEGs between KD and control samples and the list of IRGs. Candidate genes were selected using least absolute shrinkage and selection operator (LASSO) regression analysis. Candidate genes with consistent expression differences between KD and control in both GSE145725 and GSE7890 datasets were screened as biomarkers. An alignment diagram was constructed and validated, and in silico immune infiltration analysis and drug prediction were performed. Finally, RT-qPCR was performed on KD samples to analyze the expression of the identified biomarkers.ResultsA total of 889 DEGs were identified from the GSE145725 dataset, 169 of which were IRGs. Three candidate genes (TRIM32, LPAR1 and FOXF1) were identified by the LASSO regression analysis, and expression validation analysis suggested that FOXF1 and LPAR1 were down-regulated in KD samples and TRIM32 was up-regulated. All three candidate genes had consistent changes in expression in both the GSE145725 and GSE7890 datasets. An alignment diagram was constructed to predict KD. Effector memory CD4 T cells, T follicular helper cell, Myeloid derived suppressor cell, activated dendritic cell, Immature dendritic cell and Monocyte were differentially expressed between the KD and control group. Sixty-seven compounds that may act on FOXF1, 108 compounds that may act on LPAR1 and 56 compounds that may act on TRIM32 were predicted. Finally, RT-qPCR showed that the expression of LPAR1 was significantly lower in KD samples compared to normal samples whereas TRIM32 was significantly higher, while there was no difference in the expression of FOXF1.ConclusionThis study provides a new perspective to study the relationship between IRGs and KD.
Systematic review for the development of a core outcome set for monofocal intraocular lenses for cataract surgery
Authors: Tarricone Rosanna , Rognoni Carla , Ciarlo Anita , Giabbani Ilaria , Novello Leonardo , Balestrieri Marco , Costa Giacomo , Favuzza Eleonora , Mencucci Rita , Taroni Leonardo , Tognetto Daniele , Giglio Rosa 
Published: February 2024

IntroductionThe aim of the study was to define a core outcome set (COS) to be measured following cataract surgery for the postoperative evaluation of monofocal intraocular lenses (IOLs). Compared to current COSs, the present work provides updates considering the advances in the technology due to the development of new generation monofocal IOLs, which are characterized by a safety profile comparable to standard monofocal IOLs but with an extended range of intermediate vision.MethodsHealthcare professionals (ophthalmologist surgeons) and patients were involved in the selection of outcomes to be included in the COS, starting from a list of indicators retrieved from a systematic literature search. The search considered observational studies with both a retrospective or prospective design, case studies and classic randomized controlled trials (RCTs). A mixed methodology integrating a Delphi-driven and an expert panel approach was adopted to reach an agreement among clinicians, while patients were involved in the completion of a questionnaire.ResultsThe final COS included 15 outcomes. Eleven outcomes, all clinical, were considered for inclusion after a joint discussion among ophthalmologists; seven outcomes were linked to visual acuity, while the remaining to contrast sensitivity, refractive errors, aberrations and adverse events. Measurement metrics, method of aggregation and measurement time point of these outcomes were specified. The most important aspects for the patients were (1) quality of life after cataract surgery, (2) the capacity to perform activities requiring good near vision (e.g., reading), (3) spectacle independence, and (4) safety of movements without fear of getting hurt or falling (intermediate vision).DiscussionIn a context with limited healthcare resources, it is important to optimize their use considering also the preferences of end-users, namely patients. The proposed COS, developed involving both ophthalmologists and patients, provides an instrument for the postoperative evaluation of different technologies in the context of monofocal IOLs, which can be used not only in clinical trials but also in clinical practice to increase the body of real-world evidence.
Recent status and trends of nanotechnology in cervical cancer: a systematic review and bibliometric analysis
Authors: Song Xiangzhi , Li Xun , Tan Zhiwei , Zhang Lushun 
Published: February 2024

BackgroundCervical cancer is currently the second leading cause of cancer death among women from developing countries (1). However, there is a lack of effective treatment methods, and the existing treatments often result in significant adverse reactions and high chances of recurrence, which ultimately impact the prognosis of patients. As a result, the application of nanotechnology, specifically nanoparticle-based approaches, in the diagnosis and treatment of cervical cancer has gained significant attention. This study aims to examine the current research status and future development trends of nanotechnology in relation to cervical cancer using a bibliometric perspective.MethodsA bibliometric analysis was performed to gather relevant research papers from the Web of Science database. VOSviewer and CiteSpace were utilized to conduct quantitative analysis and identify hot topics in the field, focusing on countries, institutions, journals, authors, and keywords.ResultA total of 997 eligible literature were retrieved. From January 1, 2014 to September 20, 2023, the overall number of publications showed an upward trend. The paper mainly comes from China (n=414). The main institution is the Chinese Academy of Sciences (n=62), and 60% of the top 10 institutions in the number of documents issued are from China. First authors Ma, Rong (n=12) and Alifu, Nuernisha (n=12). The journal with the highest publication volume is ACS Applied Materials&amp;INTERFACES (n=35), and the journal with the highest citation frequency is BIOMATERIALS (n=508). “Nanoparticles (n=295)”, “cervical cancer (n=248)”, and “drug delivery (n=218)” are the top three most frequently occurring keywords. In recent years, photothermal therapy and indocyanine green have become research hotspots.ConclusionThe application of nanotechnology in the field of cervical cancer has garnered considerable attention. Nanoparticles-based methods for diagnosis, administration, and treatment have proven to be instrumental in enhancing the sensitivity of cervical cancer detection, improving the accuracy and efficiency of administration, and reducing drug toxicity. Enhancing treatment efficacy and improving patient prognosis have emerged as current research priorities and future directions.
Ivacaftor pharmacokinetics and lymphatic transport after enteral administration in rats
Authors: Pozniak Jiří , Ryšánek Pavel , Smrčka David , Kozlík Petr , Křížek Tomáš , Šmardová Jaroslava , Nováková Anežka , Das Debanjan , Bobek Daniel , Arora Mahak , Hofmann Jiří , Doušová Tereza , Šíma Martin , Slanař Ondřej 
Published: February 2024

Background: Ivacaftor is a modern drug used in the treatment of cystic fibrosis. It is highly lipophilic and exhibits a strong positive food effect. These characteristics can be potentially connected to a pronounced lymphatic transport after oral administration.Methods: A series of studies was conducted to describe the basic pharmacokinetic parameters of ivacaftor in jugular vein cannulated rats when dosed in two distinct formulations: an aqueous suspension and an oil solution. Additionally, an anesthetized mesenteric lymph duct cannulated rat model was studied to precisely assess the extent of lymphatic transport.Results: Mean ± SD ivacaftor oral bioavailability was 18.4 ± 3.2% and 16.2 ± 7.8%, respectively, when administered as an aqueous suspension and an oil solution. The relative contribution of the lymphatic transport to the overall bioavailability was 5.91 ± 1.61% and 4.35 ± 1.84%, respectively.Conclusion: Lymphatic transport plays only a minor role in the process of ivacaftor intestinal absorption, and other factors are, therefore, responsible for its pronounced positive food effect.
Identification of cotton pest and disease based on CFNet- VoV-GCSP -LSKNet-YOLOv8s: a new era of precision agriculture
Authors: Li Rujia , He Yiting , Li Yadong , Qin Weibo , Abbas Arzlan , Ji Rongbiao , Li Shuang , Wu Yehui , Sun Xiaohai , Yang Jianping 
Published: February 2024

IntroductionThe study addresses challenges in detecting cotton leaf pests and diseases under natural conditions. Traditional methods face difficulties in this context, highlighting the need for improved identification techniques.MethodsThe proposed method involves a new model named CFNet-VoV-GCSP-LSKNet-YOLOv8s. This model is an enhancement of YOLOv8s and includes several key modifications: (1) CFNet Module. Replaces all C2F modules in the backbone network to improve multi-scale object feature fusion. (2) VoV-GCSP Module. Replaces C2F modules in the YOLOv8s head, balancing model accuracy with reduced computational load. (3) LSKNet Attention Mechanism. Integrated into the small object layers of both the backbone and head to enhance detection of small objects. (4) XIoU Loss Function. Introduced to improve the model's convergence performance.ResultsThe proposed method achieves high performance metrics: Precision (P), 89.9%. Recall Rate (R), 90.7%. Mean Average Precision (mAP@0.5), 93.7%. The model has a memory footprint of 23.3MB and a detection time of 8.01ms. When compared with other models like YOLO v5s, YOLOX, YOLO v7, Faster R-CNN, YOLOv8n, YOLOv7-tiny, CenterNet, EfficientDet, and YOLOv8s, it shows an average accuracy improvement ranging from 1.2% to 21.8%.DiscussionThe study demonstrates that the CFNet-VoV-GCSP-LSKNet-YOLOv8s model can effectively identify cotton pests and diseases in complex environments. This method provides a valuable technical resource for the identification and control of cotton pests and diseases, indicating significant improvements over existing methods.
The relationship of kinesiophobia in patients with lymphedema: a case-control investigation
Authors: Monteiro Ana Júlia , de Labra Carmen , Losa-Iglesias Marta Elena , Dias Adriano , Becerro-de-Bengoa-Vallejo Ricardo , Silva-Migueis Helena , Macedo Filipe , López-López Daniel , Gómez-Salgado Juan 
Published: February 2024

IntroductionKinesiophobia and lymphedema appear to be related conditions, and it is important to understand this relationship, as many of the symptoms and comorbidities presented by individuals with lower limb lymphedema are prevented and treated through movement, thus constituting kinesiophobia as a barrier to intervention. The objective of this study is, therefore, to evaluate and analyze the kinesiophobic beliefs reported by individuals with and without lower limb lymphedema, regarding the agreement, severity and differences found, and to establish levels of kinesiophobia.MethodsA case-control study with a total sample of 80 participants (40 with lower limb lymphedema and 40 without) was performed. Both groups (with and without lymphedema) were characterized anthropologically, sociodemographically, and clinically. In the case group, lymphedema was evaluated. Participants in both groups completed the Tampa Scale for Kinesiophobia - 13 items (TSK-13).ResultsIndividuals with lower limb lymphedema had higher TSK-13 scores than their matched group without lymphedema. The items belonging to the activity avoidance subscale had the highest agreement and score in both groups. Differences between groups were mainly established for items belonging to the somatic focus subscale, showing that individuals with lower limb lymphedema have kinesiophobic beliefs related to the perceived severity of their lymphedema. The prevalence of kinesiophobia was increased in both groups, but the severity was mild.ConclusionsConsidering the apparent tendency of people with lower limb lymphedema to present kinesiophobia and movement-limiting beliefs regarding the condition, greater attention should be paid to its assessment, prevention and treatment from a multidisciplinary and multimodal perspective, which takes into account the multiplicity of factors inherent to kinesiophobia and lymphedema and thus reduce their impact on the management of lymphedema.
Integrative analysis of RNA-sequencing and microarray for the identification of adverse effects of UVB exposure on human skin
Authors: Jang Yujin , Na Hye-Won , Shin Dong Yeop , Lee Jun , Han Jun Pyo , Kim Hyun Soo , Kim Su Ji , Choi Eun-Jeong , Lee Charles , Hong Yong Deog , Kim Hyoung-June , Seo Young Rok 
Published: February 2024

BackgroundUltraviolet B (UVB) from sunlight represents a major environmental factor that causes toxic effects resulting in structural and functional cutaneous abnormalities in most living organisms. Although numerous studies have indicated the biological mechanisms linking UVB exposure and cutaneous manifestations, they have typically originated from a single study performed under limited conditions.MethodsWe accessed all publicly accessible expression data of various skin cell types exposed to UVB, including skin biopsies, keratinocytes, and fibroblasts. We performed biological network analysis to identify the molecular mechanisms and identify genetic biomarkers.ResultsWe interpreted the inflammatory response and carcinogenesis as major UVB-induced signaling alternations and identified three candidate biomarkers (IL1B, CCL2, and LIF). Moreover, we confirmed that these three biomarkers contribute to the survival probability of patients with cutaneous melanoma, the most aggressive and lethal form of skin cancer.ConclusionOur findings will aid the understanding of UVB-induced cutaneous toxicity and the accompanying molecular mechanisms. In addition, the three candidate biomarkers that change molecular signals due to UVB exposure of skin might be related to the survival rate of patients with cutaneous melanoma.
Current scenario and challenges of clinical pharmacists to implement pharmaceutical care in DRG/DIP payment hospitals in China: a qualitative interview study
Authors: Gao Suyu , Wang Xuanxuan , Lu Yun , Liu Yunkun , Jiang Qiaoli , Feng Jiajia , Kong Weihua , Lin Likai , Cheng Hong 
Published: February 2024

PurposeThe Diagnosis-Related Group (DRG) or Diagnosis-Intervention Packet (DIP) payment system, now introduced in China, intends to streamline healthcare billing practices. However, its implications for clinical pharmacists, pivotal stakeholders in the healthcare system, remain inadequately explored. This study sought to assess the perceptions, challenges, and roles of clinical pharmacists in China following the introduction of the DRG or DIP payment system.MethodsQualitative interviews were conducted among a sample of clinical pharmacists. Ten semi-structured interviews were conducted, either online or face to face. Thematic analysis was employed to identify key insights and concerns related to their professional landscape under the DRG or DIP system.ResultsClinical pharmacists exhibited variable awareness levels about the DRG or DIP system. Their roles have undergone shifts, creating a balance between traditional responsibilities and new obligations dictated by the DRG or DIP system. Professional development, particularly concerning health economics and DRG-based or DIP-based patient care, was highlighted as a key need. There were calls for policy support at both healthcare and national levels and a revised, holistic performance assessment system. The demand for more resources, be it in training platforms or personnel, was a recurrent theme.ConclusionThe DRG or DIP system’s introduction in China poses both opportunities and challenges for clinical pharmacists. Addressing awareness gaps, offering robust policy support, ensuring adequate resource allocation, and recognizing the evolving role of pharmacists are crucial for harmoniously integrating the DRG or DIP system into the Chinese healthcare paradigm.