bluuebunny/crossref_metadata_2025_split huggingface dataset:
Torsade de pointes associated with long-term antiretroviral drugs in a patient with HIV: a case report
Authors: Mu Xuechun , Duan Yujiao , Xu Qiuhua , Wang Sa , Gao Guiju , Han Ning , Zhao Hongxin 
Published: October 2023

With the improving life expectancy of patients with human immunodeficiency virus (HIV), there is an increasing health concern of potential toxicity and drug interactions of long-term antiretroviral therapies. We describe a female patient with HIV, who was admitted to the emergency department following an unexplained loss of consciousness. This patient had been on antiretroviral therapy comprising tenofovir disoproxil fumarate, lamivudine, and lopinavir/ritonavir for 12 years. Coincidentally, she had been prescribed terfenadine for urticaria recently. After 3 days on this medication, she suddenly lost her consciousness, with a distinctive electrocardiogram alteration characterized by QT prolongation and torsade de pointes. This symptom recurred several times over a span of 2 days. We postulate that the primary instigator was an elevated concentration of terfenadine, which can be traced back to her antiretroviral therapy regimen comprising lopinavir/ritonavir. This drug is known to impede the metabolism of cytochrome P450 3A4 substrates and consequently elevate terfenadine concentrations.
Exploring challenges in later-life relationships: a qualitative study of the queries posted on counselling websites
Authors: Svačinka Stanislav , Ševčíková Anna , Gottfried Jaroslav 
Published: October 2023

IntroductionDivorce rates among individuals aged 50 and above are on the rise. Given the greater life expectancy compared to previous generations, this is an issue that is affecting an increasing number of people. Therefore, it warrants an inquiry into the challenges these individuals encounter in their intimate relationships.MethodsThis study analyzed 225 relationship-related queries posted on Czech counselling websites to identify the strains and stressor patterns that older adults face in their relationships. The queries were limited to those that concerned themes and problems related to partnerships, were posted by one of the partners aged 60 or over, and were analyzed using inductive thematic analysis.ResultsFour main relationship issues were identified: infidelity and jealousy; relationship estrangement and cooling; undesirable changes in personality; and illness and somatic issues. Additionally, three recurring themes were identified that made the problems more demanding and that were specific to older age: lack of norms for relationships in that age group, absence of resources to tackle the issues, and personal calculation for Time Spent and Time Remaining.DiscussionThe research found that the types of problems encountered by older adults were similar to those experienced by younger individuals. However, the way these problems were perceived and processed was influenced by specific aspects of aging, such as societal expectations, available coping resources, and the perception of time. The findings also highlighted the challenges faced by older adults in terms of relationship norms, sexual functioning, and personality changes.
Indirect adjusted comparison of 6-month clinical outcomes between esketamine nasal spray and other real-world polypharmacy treatment strategies for treatment resistant depression: results from the ICEBERG study
Authors: Oliveira-Maia Albino J. , Rive Benoit , Morrens Joachim , Godinov Yordan , Cabrieto Jedelyn , Perualila Nolen , Mulhern-Haughey Siobhán 
Published: October 2023

BackgroundThe efficacy of esketamine nasal spray (NS) as a rapid-acting agent for treatment resistant depression (TRD) was demonstrated in comparisons with placebo, when both were given in addition to a newly initiated selective serotonin reuptake inhibitor (SSRI)/serotonin norepinephrine reuptake inhibitor (SNRI). How esketamine NS compares with commonly used real-world (RW) polypharmacy treatment strategies is not known.MethodICEBERG was an adjusted indirect treatment comparison that analysed data from SUSTAIN-2 (NCT02497287; clinicaltrials.gov), a long-term, open-label study of esketamine NS plus SSRI/SNRI, and the European Observational TRD Cohort (EOTC; NCT03373253; clinicaltrials.gov), an observational study of routine clinical practice. Data were compared between patients receiving esketamine NS (SUSTAIN-2) and those from the EOTC treated with polypharmacy treatment strategies, either combination or augmentation. Analyses were adjusted for potential confounders, using rescaled average treatment effect among treated estimates. Threshold analyses were conducted to assess potential impact of unmeasured confounders on the robustness of analyses where esketamine NS was found to be significantly superior. Sensitivity analyses were used to understand the impact of analysis method selection and data handling.ResultsEsketamine NS treatment resulted in a higher probability of 6-month response (49.7% [95% confidence interval (CI) 45.6–53.9]) and remission (33.6% [95% CI 29.7–37.6]) versus RW polypharmacy (26.8% [95% CI 21.0–32.5] and 19.4%, [95% CI 14.2–24.6], respectively). Relative risk calculations showed esketamine NS was 1.859 (95% CI 1.474–2.345; p &lt; 0.0001) times as likely to result in response and 1.735 (1.297–2.322; p = 0.0002) times as likely to result in remission versus RW polypharmacy at 6 months. Threshold and extensive sensitivity analyses supported that analyses of esketamine NS superiority were robust.ConclusionICEBERG supports esketamine NS being superior to current RW individualized polypharmacy strategies, including augmentation, with benefits extending beyond acute use, to improved chance of 6-month response and remission. While unobserved confounding factors may certainly impact results of an indirect comparison, threshold analysis supported a low likelihood of this affecting the conclusions.To view an animated summary of this publication, please click on the Supplementary video.
Establishing Age-Based Color Changes for the American Burying Beetle, Nicrophorus americanus Olivier, with Implications for Conservation Efforts
Authors: McMurry Robert Shane , Cavallaro Michael C. , Shufran Andrine , Hoback William Wyatt 
Published: October 2023

The American burying beetle, Nicrophorus americanus Olivier, is a federally protected insect that once occupied most of eastern North America. Adult beetles feature distinct, recognizable markings on the pronotum and elytra, and color changes with age have been observed. Among the challenges faced by research scientists and conservation practitioners is the ability to determine beetle age in the field between and including teneral (young) and senescent (old) adult stages. Using 20 (10 male and 10 female) captive-bred beetles, we characterized the change in greyscale and red, green, and blue (RGB) color channels over the lifespan of each beetle for field-aging applications. Individual beetles were photographed at set intervals from eclosion to death, and color data were extracted using open-source ImageJ Version 1.54f software. A series of linear mixed-effects models determined that red color showed the steepest decrease among all color channels in the pronotum and elytral markings, with a more significant decrease in the pronotum. The change in greyscale between the pronotum and elytral markings was visibly different, with more rapid darkening in the pronotum. The resulting pronotum color chart was tested under field conditions in Oklahoma, aging 299 adult N. americanus, and six age categories (day range) were discernable by eye: teneral (0–15), late teneral (15–31), early mature (31–45), mature (45–59), early senescent (59–76), and senescent (76–90). The ability to more precisely estimate age will improve population structure estimates, laboratory breeding programs, and potential reintroduction efforts.
Review Penggayaan Bangunan Casa Batllo: Art Nouveau
Authors: Putri Radityasari Raden Roro , Nurulrahma Ajeng Ayu , Ramdhani Dea , Yahya Muhammad Hilmi 
Published: October 2023

Casa Batllo merupakan bangunan yang pada awalnya merupakan sebuah tempat tinggal namun sekarang sudah beralih menjadi sebuah museum terletak di Barcelona, Spanyol. Casa Batllo dirancang oleh Antoni Gaudi yang merupakan desainer terkenal asal spanyol. Proyek rumah ini dilakukan tahun 1904 dengan pengerjaan konstruksi dari tahun 1904 hingga 1907. Casa Batllo diidentifikasi sebagai bangunan dengan gaya modernisme dan art nouveau. Art Nouveau merupakan gerakan internasional yang menggabungkan dua hal yang sangat berpengaruh di dunia yaitu: seni dan alam. Di Barcelona, art nouveau selain memadukan alam dan seni, juga sangat dipengaruhi dengan gaya modern. Casa Batllo disebut juga sebagai “the most emblematic work” atau karya paling simbolis di Barcelona. Salah satu fitur yang sangat mencolok adalah fasad yang berwarna dengan bentuknya yang melengkung. Hal yang sangat menarik dan menunjukkan gaya art nouveau lainnya adalah pemakaian tulang. Kolom tinggi dengan warna kulit menyerupai tulang menghiasi bagian jendela di fasad. Hal ini membuat Casa Batllo mendapat julukan “The House of Bones” (Rumah Tulang). Dengan dibuatnya artikel ini diharapkan terciptanya pengetahuan tentang elemen-elemen dan penggayaan yang digunakan dalam bangunan Casa Batllo. Data dalam penelitian ini diambil dan dikumpulkan dari berbagai literatur kepustakaan dan jenis data yang diperoleh bersifat kualitatif.
ORÇAMENTO PÚBLICO - TRANSPARÊNCIA DAS NECESSIDADES SOCIAIS
Authors: Silva Luciele Costa Candido da , Santos Adilson Pereira dos , Santos Vinicius de Souza 
Published: October 2023

A elaboração do orçamento público e sua execução durante o exercício tem de estar regado de transparência e participação popular, quanto maior o conhecimento da sociedade acerca dos seus direitos e deveres enquanto cidadãos maior será o retorno com serviços públicos que atendam de fato as necessidades e particularidades de cada região. Tomou-se como base para pesquisa o orçamento a nível municipal, enfatizando a transparência da gestão em relação aos gastos e participação da sociedade na sua elaboração e acompanhamento e fiscalização da sua execução.
Studi Pertumbuhan Miselia Jamur Merang (Volvariella volvaceae) G2 Isolat FP005 Faperta UNSIKA Pada Beberapa Bahan Alternatif Media In Vitro
Authors: Rustaman Aisyah Nur , Syah Bastaman , Widyodaru Nurcahyo , Lestari Ani 
Published: October 2023

Straw mushroom is one of the horticultural commodities that is in great demand by the community. The successful cultivation of straw mushrooms is determined by the quality of the seeds of the molten mushroom. Tissue culture is one of the efforts to get quality seeds. Quality seedlings are seen from the brood of the merang fungus and the quality of pure culture. Making pure culture is still constrained in making in vitro media, especially alternative media materials. This study aims to obtain the best results from the growth of G2 FP005 mycelia on alternative media materials in vitro. This research was conducted at the Biotechnology and Plant Breeding Laboratory, Faculty of Agriculture, Singaperbangsa University, Karawang from April to May 2023. The research method used was a single factor Complete Randomized Design (CRD) with 7 treatments and 5 replications: A (100% PDA); B (100% Charcoal Husk Solution); C (100% Husk Solution); D (80% PDA + 20% Husk Charcoal Solution), E (75% PDA + 25% Husk Solution), F (50% Husk Charcoal Solution + 50% Husk Solution); G (50% PDA + 25% Husk Charcoal Solution + 25% Husk Solution). The effect of the treatment was analyzed using variance and if the F test was significant at 1% level, then to find out which treatment was the best it was continued with the DMRT (Duncan Multiple Range Test) advanced test at the 1% level of significance. The results achieved from this study were that there was a significant effect of using alternative media materials on the growth of the straw mushroom mycelia. Alternative media 80% PDA + 20% rice husk charcoal gave the highest mycelia colony diameter of 7.88 cm and the highest mycelial colony growth rate of 2,878 cm/day. Keywords: Unsika Faperta Isolate, Straw Mushroom, Tissue Culture.
UNDERSTANDING CYBERBULLYING ON TWITTER AMONG K-POP FANS IN MALAYSIA
Authors: Hassim Mohammad Nurhafiz , Ahmad Nur Fathiah 
Published: October 2023

Cyberbullying among K-pop fans in Malaysia is still unclear, but the consequences of this behavior are becoming a growing problem. The problem of cyberbullying cannot be simplified with Malaysia's current laws. There is an urgent need for K-pop fans on Twitter to understand cyberbullying and find ways to combat it. In this study, the researcher highlights the most common types of cyberbullying among K-pop fans on Twitter. The aim of this study is to understand cyberbullying on Twitter among K-pop fans in Malaysia. It specifically examines the community of K-pop fans on Twitter. There are 3 research objectives in this study, namely (i). To discover the most common types of cyberbullying among K-pop fans on Twitter, (ii). To understand the social activities that facilitate cyberbullying among K-pop fans on Twitter, and (iii). To determine whether K-pop fans on Twitter are aware of ways to combat cyberbullying. This research is based on data obtained through in-depth interviews with mass communication students. The data was analyzed using thematic analysis to determine the most common types of cyberbullying and ways to combat cyberbullying. The study found that K-pop fans know what behavior is considered cyberbullying, what types of cyberbullying to expect and what can be done about it. The results of the study also suggest that a different approach needs to be taken to better understand how to combat cyberbullying. It is hoped that the study can help to improve the prevention of cyberbullying on Twitter among K-pop fans.
Keywords: Cyberbullying, Fans, K-pop, Twitter
Impact of Human Capital Development and Economic Growth on Global Competitiveness
Authors: Minhaj Nayab , Ahmed Roohi 
Published: October 2023

The focus of this study is on the growing importance of human capital development in a number of developed, emerging, and developing countries, including Pakistan. The panel data analysis uses traditional approaches to examine observations from 1990 to 2019. The study’s main goal was to look at the impact of human capital development and growth on competitiveness. The dependent variable in the model is the global competitiveness index (GCI), with human capital, GDP per capita, GNP per capita, physical capital growth, and inflation as explanatory variables. Empirical data consistently demonstrates that human capital is the paramount asset in all economies, regardless of their development status. Its strong connection to competitiveness underscores the need to thoroughly evaluate policies impacting human capital development across nations. This assessment is crucial for understanding the interplay of policies and human capital development, a key factor in achieving desired outcomes.
On Predicting Growth Factor Data of Covid-19 Epidemic Using Hybrid Arima-Ann Model
Authors: Safi Samir K. 
Published: October 2023

The Autoregressive Integrated Moving Average (ARIMA) model cannot capture the nonlinear patterns exhibited by the 2019 coronavirus (COVID-19) in terms of daily growth factor. As a result, Artificial Neural Networks (ANNs) and Hybrid ARIMA-ANN models have been successfully applied to resolve problems with nonlinear estimation. We compare the forecasting performance of these models using real, worldwide, daily COVID-19 data. The best forecasting model selected was compared using the forecasting assessment criterion known as mean absolute error. The main finding results show that the ANN model is more efficient than the ARIMA and Hybrid ARIMA-ANN models. The main finding from the ANN model analysis indicates that the magnitude of the increase in growth factor over time is rising in general while the percentage change in the growth factor is declining. This may be the result of the social distancing, safety, and cautionary measures mandated by governments worldwide.
Quasi-simultaneous Optical Flux and Polarization Variability of the Binary Super Massive Black Hole Blazar OJ 287 from 2015 to 2023: Detection of an Anticorrelation in Flux and Polarization Variability
Authors: Gupta Alok C. , Kushwaha Pankaj , Valtonen Mauri J. , Savchenko Sergey S. , Jorstad Svetlana G. , Imazawa Ryo , Wiita Paul J. , Gu Minfeng , Marscher Alan P. , Zhang Zhongli , Bachev Rumen , Borman G. A. , Gaur Haritma , Grishina T. S. , Hagen-Thorn V. A. , Kopatskaya E. N. , Larionov V. M. , Larionova E. G. , Larionova L. V. , Morozova D. A. , Nakaoka T. , Strigachev A. , Troitskaya Yulia V. , Troitsky I. S. , Uemura M. , Vasilyev A. A. , Weaver Z. R. , Zhovtan A. V. 
Published: October 2023

Abstract
We study the optical flux and polarization variability of the binary black hole blazar OJ 287 using quasi-simultaneous observations from 2015 to 2023 carried out using telescopes in the USA, Japan, Russia, Crimea, and Bulgaria. This is one of the most extensive quasi-simultaneous optical flux and polarization variability studies of OJ 287. OJ 287 showed large amplitude, ∼3.0 mag flux variability, large changes of ∼37% in degree of polarization, and a large swing of ∼215° in the angle of the electric vector of polarization. During the period of observation, several flares in flux were detected. Those flares are correlated with a rapid increase in the degree of polarization and swings in electric vector of polarization angle. A peculiar behavior of anticorrelation between flux and polarization degree, accompanied by a nearly constant polarization angle, was detected from JD 2,458,156 to JD 2,458,292. We briefly discuss some explanations for the flux and polarization variations observed in OJ 287.
The effect of body weight and psychological characteristics on periodontal disease development
Authors: Skrypnyk Maksym , Petrushanko Tatiana , Neporada Karine , Vynnyk Nataliia , Skikevych Margarita , Skrypnyk Igor 
Published: October 2023

Aim: The aim of the study was to examine the association between periodontal health in young patients with various body mass indexes and psychological traits such as temperament, level of anxiety, and autonomic nervous system tone.
Materials and methods: The study included 132 male and female subjects aged 18–22 years with different body mass indexes (BMI). They were allocated into four groups by their BMIs: normal weight, overweight, and first- and second-degree obesity. We completed periodontal charts for all patients and evaluated basic oral hygiene and periodontal indexes, such as the Green-Vermillion index (OHI), the approximal plaque index by Lange (API), and papilla bleeding index by Saxer & Mühlemann (PBI). Eysenck personality questionnaire, the state-trait anxiety inventory of Spielberger-Khanin, and Wayne questionnaire were used to determine the psychological characteristics.
Results: Patients with the first and second degrees of obesity were found to have the highest prevalence and severity of generalized gingivitis (up to 90%). Patients with normal BMI had significantly lower levels of extraversion and higher levels of neuroticism than the obese individuals, while subjects with extra weight and normal BMI were more emotionally stable. We found no evidence that choleric or melancholic temperament had an impact on BMI or periodontal health. However, phlegmatic temperament was found to be linked to a normal BMI, good oral hygiene, and an intact periodontium, while sanguine temperament was linked to obesity and gingivitis in young adults. A significantly higher level of state and trait anxiety was observed in obese individuals. Fifty percent of the obese subjects had disturbances of the functional state of the cardiovascular system and the tone of the autonomic nervous system.
Conclusions: Because obesity and periodontal pathology are multifactorial diseases linked to lifestyle, stress tolerance, and habits, personality temperament may play a causal role in their development.
La zone du dehors
Authors: Grégoire Axelle , Fouillet Aurélien 
Published: October 2023

À la manière d’une carte blanche, la revue donne la parole à des savoirs élaborés par d’autres disciplines : Aurélien Fouillet, sociologue et ébéniste, s’interroge sur les écarts féconds que permet le jeu. Puisant des figures dans le lexique des mouvements corporels (le pas de côté, la luxation) ou des cartes à jouer (le boiteux, l’acrobate), il nous invite à percevoir comment nos jeux déstabilisent la cohérence apparente de nos sensations.
La terminologie sur les professionnels de la communication militaire : genèse et contextualisation.
Authors: Bizimana Aimé-Jules 
Published: October 2023

Dans la foulée de l’actualité sur le conflit Russie-Ukraine qui relance le débat sur le rôle de l’information en temps de guerre, cet article retrace l’évolution de la terminologie qui désigne les professionnels de la communication militaire. À travers une approche diachronique dans le contexte anglo-saxon (États-Unis, Canada et Royaume-Uni), l’auteur révèle les usages terminologiques et leurs métamorphoses à partir de la Grande Guerre. L’article revient sur différentes phases de l’institutionnalisation et de la professionnalisation des « officiers de communication » militaires et offre une réflexion critique sur une terminologie fondée à la fois sur un discours de distanciation avec la propagande et sur un discours de légitimation d’un champ professionnel concurrent au journalisme et qui a acquis une place importante dans la communication militaire institutionnelle et opérationnelle.
Prescriptions visuelles de l’habiter urbain. Le rôle des documents visuels dans la communication autour de projets de réhabilitation.
Authors: Després-Lonnet Marie , Spano William 
Published: October 2023

À une époque marquée par le souci de repenser la ville et les modes de vie qui lui sont associés, certains quartiers voient leur organisation et leur développement profondément transformés. Ainsi, le motif de la « smart city » ou ville « intelligente » amène politiques, architectes, journalistes et urbanistes à projeter sur les quartiers « en rénovation » diverses représentations visuelles qui s’appuient sur le bâti existant pour produire des « insertions », destinées à montrer comment les constructions à venir prendront place dans le lieu choisi. L’analyse des images mobilisées par chaque catégorie d’acteurs et des textes qui les accompagnent, permet de montrer que les zones concernées sont prises en tension entre différentes prescriptions d’usages et formes d’habiter ces lieux qui passent notamment par la mise en scène de ce que sont ou seraient les habitants et les occupants légitimes des lieux.
Vidéos de violences policières : la « preuve par l’image » ?
Authors: Riboni Ulrike Lune 
Published: October 2023

Les « vidéos de violences policières » sont au cœur d’âpres débats en France depuis le mouvement des Gilets jaunes initié en 2018 et font l’objet d’une attention renouvelée un peu partout dans le monde, comme aux États-Unis récemment avec la mort filmée de George Floyd. Elles sont au cœur de débats de sens et mettent en cause l’évidence probatoire dont elles seraient porteuses en échouant souvent à soutenir la version des victimes dans les procès pénaux. Pour autant, leur incidence sur le débat public paraît tangible. L’article s’attache à interroger la catégorie de preuve visuelle à la lumière de cet objet protéiforme désigné comme « vidéo de violences policières ». En quelle mesure les images constituent-t‑elles une preuve et pour qui ? Quelles conditions socio-techniques sont nécessaires ? De quoi sont-elles la preuve ? Des caractéristiques visuelles aux usages et aux discours, il s’agit de saisir comment ces images interrogent la catégorie même de preuve.