bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Purslane Consumption on Obesity Indices: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Vajdi Mahdi , Hassanizadeh Shirin , Shojaei-Zarghani Sara , Bagherniya Mohammad , Askari Gholamreza 
Published: October 2023

Obesity and overweight are among the most significant global health challenges that affect both developed and developing countries, leading to various chronic diseases. Previous studies have reported inconsistent results regarding the effects of purslane supplementation on obesity indices. Therefore, the aim of this study was to perform a meta-analysis on the effects of supplementation with purslane on obesity indices among adults. Comprehensive systematic searches were performed throughout Web of Science, EMBASE, PubMed, Scopus, and Cochrane Library databases up to May 30, 2023. All randomized controlled trials (RCTs) that investigated the impact of purslane supplementation on obesity indices were included into the analysis. The I2 and Cochran’s Q tests were used to assess heterogeneity between studies. The effect sizes were reported as the weighted mean difference (WMD) and 95% confidence intervals (CIs) using a random effects model. The initial search yielded 789 studies, of which seven RCTs were included in analysis. Following purslane supplementation, body weight (BW) (WMD: −0.94 kg, 95% CI: −1.57–−0.31, and

P

= 0.002) and body mass index (BMI) (WMD: −0.53 kg/m2, 95% CI: −0.88–−0.18, and

P

: 0.001) decreased significantly. However, this meta-analysis could not show any beneficial effect of purslane supplementation on waist circumference (WC) (WMD: −0.28 cm, 95% CI: −1.47–0.91, and

P

= 0.23). In addition, there was no linear association between the duration of treatment and sample size with BW, BMI, and WC. In conclusion, this meta-analysis showed a significant effect of purslane supplementation on BMI and BW but not on WC in adults, suggesting that it has the potential to be used therapeutically. Moreover, the combined results of previous RCTs indicate that purslane is a safe and effective intervention for reducing obesity indices in subjects with metabolic syndrome or obesity. As such, the consumption of purslane may have indirectly contributed to the amelioration of clinical symptoms in diseases with metabolic disorders, owing to its impact on some obesity indices. However, given the limitations and the low number of included studies in the present meta-analysis, more large-scale RCTs are needed to shed light on this issue.
Mobile Phone Use and Risks of Overall and 25 Site-Specific Cancers: A Prospective Study from the UK Biobank Study
Authors: Zhang Yanjun , Zhang Yuanyuan , Ye Ziliang , Yang Sisi , Liu Mengyi , Wu Qimeng , Zhou Chun , He Panpan , Gan Xiaoqin , Qin Xianhui 
Published: October 2023

Abstract

Background:
The association between mobile phone use and incident cancers remains uncertain. We aimed to investigate the relationships of mobile phone use with incident overall and 25 site-specific cancers in men and women.

Methods:
A total of 431,861 participants ages 38 to 73 years without prior cancers were included from the UK Biobank. Of these, 46.7% were male. Participants who used a mobile phone at least once per week to make or receive calls were defined as mobile phone users. The study outcomes were incident overall and 25 site-specific cancers.

Results:
During a median follow-up of 10.7 years, 35,401 (17.5%) men and 30,865 (13.4%) women developed overall cancer. Mobile phone use was significantly associated with higher risks of incident overall cancer [HR, 1.09; 95% confidence interval (CI): 1.06–1.12], nonmelanoma skin cancer (NMSC; HR, 1.08; 95% CI: 1.03–1.14), urinary tract cancer (HR, 1.18; 95% CI:1.05–1.32), and prostate cancer (HR, 1.19; 95% CI: 1.13–1.25) in men, and incident overall cancer (HR, 1.03; 95% CI: 1.00–1.06), NMSC (HR, 1.07; 95% CI: 1.01–1.13), and vulva cancer (HR, 1.74; 95% CI: 1.00–3.02) in women, but not with other cancers. Among mobile phone users, there was a dose–response relationship of length of mobile phone use with incident NMSC in men and women, and prostate cancer in men (all Ptrend &lt; 0.05).

Conclusions:
There was a dose–response relationship of length of mobile phone use with incident NMSC in men and women, and prostate cancer in men.

Impact:
Our findings underscore the importance of limiting mobile phone use or keeping a distance from mobile phone for primary prevention of NMSC and prostate cancer.
Genomic Tumor Correlates of Clinical Outcomes Following Organ-Sparing Chemoradiation Therapy for Bladder Cancer
Authors: Kamran Sophia C. , Zhou Yuzhen , Otani Keisuke , Drumm Michael , Otani Yukako , Wu Shulin , Wu Chin-Lee , Feldman Adam S. , Wszolek Matthew , Lee Richard J. , Saylor Philip J. , Lennerz Jochen , Van Allen Eliezer , Willers Henning , Hong Theodore S. , Liu Yang , Davicioni Elai , Gibb Ewan A. , Shipley William U. , Mouw Kent W. , Efstathiou Jason A. , Miyamoto David T. 
Published: October 2023

Abstract

Purpose:
There is an urgent need for biomarkers of radiation response in organ-sparing therapies. Bladder preservation with trimodality therapy (TMT), consisting of transurethral tumor resection followed by chemoradiation, is an alternative to radical cystectomy for muscle-invasive bladder cancer (MIBC), but molecular determinants of response are poorly understood.

Experimental Design:
We characterized genomic and transcriptomic features correlated with long-term response in a single institution cohort of patients with MIBC homogeneously treated with TMT. Pretreatment tumors from 76 patients with MIBC underwent whole-exome sequencing; 67 underwent matched transcriptomic profiling. Molecular features were correlated with clinical outcomes including modified bladder-intact event-free survival (mBI-EFS), a composite endpoint that reflects long-term cancer control with bladder preservation.

Results:
With a median follow-up of 74.6 months in alive patients, 37 patients had favorable long-term response to TMT while 39 had unfavorable long-term response. Tumor mutational burden was not associated with outcomes after TMT. DNA damage response gene alterations were associated with improved locoregional control and mBI-EFS. Of these alterations, somatic ERCC2 mutations stood out as significantly associated with favorable long-term outcomes; patients with ERCC2 mutations had significantly improved mBI-EFS [HR, 0.15; 95% confidence interval (CI), 0.06–0.37; P = 0.030] and improved BI-EFS, an endpoint that includes all-cause mortality (HR, 0.33; 95% CI, 0.15–0.68; P = 0.044). ERCC2 mutant bladder cancer cell lines were significantly more sensitive to concurrent cisplatin and radiation treatment in vitro than isogenic ERCC2 wild-type cells.

Conclusions:
Our data identify ERCC2 mutation as a candidate biomarker associated with sensitivity and long-term response to chemoradiation in MIBC. These findings warrant validation in independent cohorts.
Cancer Relevance of Circulating Antibodies Against LINE-1 Antigens in Humans
Authors: Vylegzhanina Alexandra V. , Bespalov Ivan A. , Novototskaya-Vlasova Ksenia A. , Hall Brandon M. , Gleiberman Anatoli S. , Yu Han , Leontieva Olga V. , Leonova Katerina I. , Kurnasov Oleg V. , Osterman Andrei L. , Dy Grace K. , Komissarov Alexey A. , Vasilieva Elena , Gehlhausen Jeff , Iwasaki Akiko , Ambrosone Christine B. , Tsuji Takemasa , Matsuzaki Junko , Odunsi Kunle , Andrianova Ekaterina L. , Gudkov Andrei V. 
Published: October 2023

Abstract

Long interspersed nuclear element-1 (LINE-1 or L1), the most abundant family of autonomous retrotransposons occupying over 17% of human DNA, is epigenetically silenced in normal tissues by the mechanisms involving p53 but is frequently derepressed in cancer, suggesting that L1-encoded proteins may act as tumor-associated antigens recognized by the immune system. In this study, we established an immunoassay to detect circulating autoantibodies against L1 proteins in human blood. Using this assay in &gt;2,800 individuals with or without cancer, we observed significantly higher IgG titers against L1-encoded ORF1p and ORF2p in patients with lung, pancreatic, ovarian, esophageal, and liver cancers than in healthy individuals. Remarkably, elevated levels of anti–ORF1p-reactive IgG were observed in patients with cancer with disease stages 1 and 2, indicating that the immune response to L1 antigens can occur in the early phases of carcinogenesis. We concluded that the antibody response against L1 antigens could contribute to the diagnosis and determination of immunoreactivity of tumors among cancer types that frequently escape early detection.

Significance:
The discovery of autoantibodies against antigens encoded by L1 retrotransposons in patients with five poorly curable cancer types has potential implications for the detection of an ongoing carcinogenic process and tumor immunoreactivity.
Decadal Variability in Spring Sea Ice Concentration Linked to Summer Temperature and NDVI on the Yukon–Kuskokwim Delta
Authors: Hendricks Amy S. , Bhatt Uma S. , Frost Gerald V. , Walker Donald A. , Bieniek Peter A. , Raynolds Martha K. , Lader Rick T. , Epstein Howard E. , Pinzon Jorge E. , Tucker Compton J. , Comiso Josefino C. 
Published: October 2023

Abstract
Rapidly warming temperatures in the Arctic are driving increasing tundra vegetation productivity, evidenced in both the satellite derived normalized difference vegetation index (NDVI) imagery and field studies. These trends, however, are not uniformly positive across the circumpolar Arctic. One notable region of negative linear NDVI trends that have persisted over the last 15 years is southwest Alaska’s Yukon–Kuskokwim Delta (YKD). Negative NDVI trends in the YKD region appear inconsistent with our understanding since tundra vegetation is temperature-limited and air temperatures have increased on the YKD. Analysis over a 40-yr record from 1982 to 2021 reveals distinct decadal variability in the NDVI time series, which continues to produce negative linear trends. Similar decadal variability is also evident in summer warmth and 100-km coastal zone spring sea ice concentrations. This suggests that decadal climate variations can dominate the trends of NDVI through their influence on the drivers of tundra vegetation, namely, coastal sea ice concentrations and summer warmth. The relationships among sea ice, summer warmth, and NDVI have changed over the 40-yr record. Seasonality analysis since 1982 shows declining sea ice concentration in spring is followed by trends of increasing temperatures, but weakly declining NDVI during the growing season. An additional key finding is that since early 2010s, the relationships between sea ice concentration and summer warmth, and sea ice concentration and NDVI have strengthened, while the relationship between NDVI and summer warmth has weakened, indicating that temperature may no longer be the primary limiting factor for Arctic tundra vegetation on the YKD.

Significance Statement
This paper addresses a curiosity of regional Arctic climate change, which is that despite increasing temperatures, spatially and temporally declining trends of vegetation productivity on the Yukon–Kuskokwim Delta appear in satellite data. This study bridges our understanding of Arctic climate relationships at varying scales and informs questions about how these relationships may change in the future.
Systematic Modeling Errors Undermine the Application of Land Data Assimilation Systems for Hydrological and Weather Forecasting
Authors: Crow Wade T. , Kim Hyunglok , Kumar Sujay 
Published: October 2023

Abstract
Due to recent advances in the development of land data assimilation systems (LDAS) and the availability of high-quality, satellite-based surface soil moisture (SSM) retrieval products, we now have unambiguous evidence that the assimilation of SSM retrievals, or their proxy, can improve the precision (i.e., correlation versus truth) of surface state estimates provided by a land surface model (LSM). However, this clarity does not yet extend to the estimation of LSM surface water fluxes that are key to hydrologic and numerical weather forecasting applications. Here, we hypothesize that a key obstacle to extrapolating realized improvements in water state precision into comparable improvements in water flux accuracy (i.e., mean absolute error) is the presence of water state–water flux coupling strength biases existing in LSMs. To test this hypothesis, we conduct a series of synthetic fraternal twin data assimilation experiments where realistic levels of state–flux coupling strength bias—involving both evapotranspiration and runoff—are systematically introduced into an assimilation LSM. Results show that the accuracy of the resulting water flux analysis is sharply reduced by the presence of such bias, even in cases where the precision of soil moisture state estimates (e.g., SSM) is improved. The rescaling of SSM observations prior to their assimilation (i.e., the most common approach for addressing systematic differences between LSMs and assimilated observations) is not always a robust strategy for addressing these errors and can, in certain circumstances, degrade water flux accuracy. Overall, results underscore the critical need to assess, and correct for, LSM water state–water flux coupling strength biases during the operation of an LDAS.

Significance Statement
Land data assimilation is the process by which land surface model estimates of water states (e.g., soil moisture) and water fluxes (e.g., runoff and evapotranspiration) are improved via the incorporation of observations. Over the past decade, substantial improvements have been made in the precision of land surface model states via the assimilation of satellite-based soil moisture information. However, to date, these improvements have not yet been extended into water flux estimates like runoff and evapotranspiration. This is a critical shortcoming since advances in important weather and hydrologic forecasting applications are dependent on the improved estimation of such fluxes. We demonstrate that this shortcoming is linked to the inability of existing land surface models to accurately describe the impact of variations in water states on water fluxes and propose strategies for overcoming this issue in future land data assimilation systems.
Firm Size and Productivity in the Informal Sector: Evidence from India
Authors: Posti Lokesh , Maiti Abhradeep 
Published: October 2023

The study analyses the debate around the ambiguous relationship between firm size and performance. We explore how productivity varies across firm sizes in the informal sector, where firm size is sensitive to formal regulations. Additionally, the study also looks into the informal firms’ quantity and quality of employment by observing wage and performance dispersion across firm sizes, thus indicating capital accumulation and exploitation. Considering the data limitations, a pseudo-panel data design was adopted by combining the three, only available, independent cross-sectional surveys by the National Sample Survey Office, spanning from 1999–2000 to 2015–2016. Potential issues such as time-invariant unobserved firm-level heterogeneity were accounted for by using panel random effects regression. Using total firm employment and total factor productivity as the primary measures of firm size and performance, we find a positive relationship between the two across all major industries. Our results stand robust against alternative firm size and performance measures. However, this positive association between size and performance indicated capital accumulation (increasing productivity with increasing size) at the expense of labour exploitation (stagnant wages across firm sizes). The obtained findings convey important policy implications for adopting a carrot-and-stick approach for the gradual formalisation of the economy. JEL Codes: D22, L25, O25
Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis
Authors: Binmadi Nada O. , Mohamed Yassmin A. 
Published: October 2023

Objective The relationship between the worst pattern of invasion (WPOI) and the prognosis of oral squamous cell carcinoma (OSCC) remains controversial. This systematic review and meta-analysis was performed to determine the impact of the WPOI on the prognosis of OSCC. Methods Studies from six databases were assessed for quality using the Newcastle–Ottawa Scale, and data were analyzed using Stata software. Results Eighteen studies involving 3954 patients showed that patients with a WPOI of 4 to 5 had significantly worse overall survival, disease-specific survival, and disease-free survival than patients with a WPOI of 1 to 3. Significant associations of the WPOI with locoregional recurrence and mortality were found. Conclusion A higher WPOI was significantly associated with a worse prognosis of OSCC across various outcomes. Incorporating the WPOI into standard histopathological assessments may guide personalized treatments and improve outcomes.
Needlestick and sharps injuries among healthcare workers in an oncology setting: a retrospective 7-year cross-sectional study
Authors: Mubarak Sawsan , Al Ghawrie Hadeel , Ammar Khawlah , Abuwardeh Razan 
Published: October 2023

Objective To assess the prevalence of needlestick and sharps injuries (NSSIs) and associated factors among healthcare workers (HCWs) at King Hussein Cancer Centre (KHCC), Amman, Jordan. Methods This retrospective cross-sectional study undertook a chart review of all HCWs that reported an NSSI between January 2015 and December 2021. Data collected included sociodemographic factors including age, sex, qualifications, and predictors of NSSIs such as working hours, work shift, and specific job roles within the oncology setting, work experience in KHCC, overall work experience and occupational category. Results A total of 355 NSSIs were included in this study with a peak prevalence in 2019 (81 of 355; 22.8%). Nurses (220 of 355; 62.0%), housekeeping staff (59of 355; 16.6%) and physicians (45 of 355; 12.7%) were the most affected occupations. NSSIs were most common in the surgical floor (65 of 355; 18.3%) and operating rooms (56 of 355; 15.8%). Blood collection (94 of 355; 26.5%) and waste collection (65 of 355; 18.3%) were the two primary procedures resulting in NSSIs. The risk of injury was significantly associated with the locations of NSSIs, procedure that caused NSSIs, shift and overall experience. Conclusion NSSIs remain common among HCWs, which highlights the need for targeted education.
Investigating compassion fatigue and predictive factors in paediatric surgery nurses
Authors: Kankaya Eda Ayten , Özer Özlü Nazife Gamze , Vural Fatma 
Published: October 2023

Background Nurses provide care to meet the complex needs of patients in the increasing workload in the health system and are at risk of compassion fatigue. The concept of compassion fatigue has begun drawing attention in the last decade, as it negatively affects nurses' physical and mental health, job performance and satisfaction, and therefore patient care quality. Objectives This study was to examine compassion fatigue and predictive factors in paediatric surgery nurses. Participants and research context The study was cross-sectional, predictive and quantitative. It was conducted with the 135 paediatric surgery nurses. The data were sent to the email addresses of the members via Google Survey. Research data were collected with the Nurse Information Form, Compassion Fatigue Scale, Life Satisfaction Scale and Multidimensional Perceived Social Support Scale. Ethical considerations After obtaining the approval of the University’s ethics committee, the study was carried out after obtaining participants’ informed written and verbal consent. Results There was a difference between the level of compassion fatigue according to the paediatric surgery unit that worked the longest and the thought of changing their profession. Burn unit nurses and nurses who were considering changing professions have higher compassion fatigue scores. When the predictors of compassion fatigue were examined, the thought of changing the nursing profession and life satisfaction were significant predictors of compassion fatigue. The thought of changing the nursing profession and life satisfaction explained 22% of compassion fatigue. The same variables and the longest working period of the paediatric surgery unit were the estimators of the level of occupational burnout; explaining 29% of occupational burnout. Conclusions Compassion fatigue, life satisfaction and perceived social support of paediatric surgery nurses are moderate. Compassion fatigue is affected by working time, the thought of changing the profession, life satisfaction and perceived social support.
Epidemiology and geographic clustering of Erdheim-Chester disease in Italy and France
Authors: Peyronel Francesco , Haroche Julien , Campochiaro Corrado , Pegoraro Francesco , Amoura Zahir , Tomelleri Alessandro , Mazzariol Martina , Papo Matthias , Cavalli Giulio , Benigno Giuseppe D. , Fenaroli Paride , Grigoratos Chrysanthos , Mengoli Maria C. , Bonometti Arturo , Berti Emilio , Savino Gustavo , Cives Mauro , Neri Iria , Pacinella Gaetano , Tuttolomondo Antonino , Marano Massimo , Muratore Francesco , Manfredi Andreina , Broccoli Alessandro , Zinzani Pier L. , Didona Biagio , Massaccesi Chiara , Buono Andrea , Ammirati Enrico , Di Lernia Vito , Dagna Lorenzo , Vaglio Augusto , Cohen-Aubart Fleur 
Published: October 2023

Abstract
This geoepidemiological study, performed in Italy and France, shows that Erdheim-Chester disease is increasingly diagnosed and cases cluster in specific geographic areas, namely southern Italy and central France. Disease frequency inversely correlates with the Human Development Index.
Response-adapted, time-limited venetoclax, umbralisib, and ublituximab for relapsed/refractory chronic lymphocytic leukemia
Authors: Hill Brian T. , Ma Shuo , Zent Clive S. , Baran Andrea M. , Wallace Danielle S. , Advani Anjali , Winter Allison , Winter Jane , Gordan Leo , Karmali Reem , Liesveld Jane L. , Mulford Deborah A. , Rowland Chris , Bui Andrew , Sportelli Peter , Miskin Hari P. , Weiss Michael S. , Friedberg Jonathan W. , Barr Paul M. 
Published: October 2023

Abstract
Many patients with chronic lymphocytic leukemia (CLL) will develop treatment resistance to Bruton tyrosine kinase (BTK) inhibitors. Phosphatidylinositol-3-kinase (PI3K) inhibitors, including umbralisib, have significant clinical activity in relapsed/refractory CLL, but prolonged exposure is associated with potential toxicities. Owing to the synergistic antitumor effects of combined PI3K and BCL-2 inhibition, we sought to explore the feasibility of response-adapted, time-limited therapy to optimize disease control while mitigating the risks of prolonged treatment. We conducted a phase 1/2 clinical trial to determine the safety and efficacy of venetoclax in combination with umbralisib and the anti-CD20 monoclonal antibody, ublituximab, (U2-VeN) in patients with relapsed/refractory CLL (N = 46) and Richter transformation (N = 5). After 12 cycles, treatment was stopped for patients with CLL who achieved undetectable minimal residual disease (uMRD). Adverse events of special interest included diarrhea in 50% of patients (11% grade 3/4), and aspartate aminotransferase and/or alanine aminotransferase elevation in 15 patients (33%), with 3 (7%) grade 3/4. There were no cases of tumor lysis syndrome related to venetoclax, with outpatient initiation in 96% of patients. The intent-to-treat overall response rate for CLL was 98% with best response of 100% in evaluable patients (42% complete responses). The end-of-treatment rate of uMRD at 10−4 in bone marrow was 77% (30/39), including a 71% uMRD rate among 14 patients refractory to prior BTK inhibitor. Time-limited venetoclax and U2 is safe and highly effective combination therapy for patients with relapsed/refractory CLL including those who have been previously treated with covalent BTK inhibitors. This trial was registered on www.clinicaltrials.gov as #NCT03379051.