bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assimilation of Transformed Retrievals From Satellite High‐Resolution Infrared Data Over the Central Pacific Area
Authors: Cherubini Tiziana , Antonelli Paolo , Businger Steven , Scaccia Paolo 
Published: October 2023

AbstractA month‐long data assimilation experiment is carried out to assess the impact of CrIS and IASI Transformed Retrievals (TRs) on the accuracy of analyses and forecasts from a 3‐hr Weather Research and Forecasting cycling system implemented over the central North Pacific Ocean. Conventional observations and satellite MicroWave (MW) radiance data are assimilated along with TRs in comparative experiments. Both the NCEP Global Forecasting System and the European Centre for Medium‐Range Weather Forecasts analyses are used in the evaluation process. The results show that the assimilation of TRs alone, and in combination with MW radiance assimilation, have the greatest impact on the characterization of the moisture field in the middle atmospheric levels (800–300 hPa), and particularly in the lower portion (800–600 hPa). The latter improvement is likely due to a refinement in the vertical definition of the trade‐wind inversion.
Heavy Rainfall Forecast of Landfalling Tropical Cyclone Over China With an Upgraded DSAEF_LTP Model
Authors: Wang Mingyang , Ding Chenchen , Ren Fumin , Zhang Da‐Lin , Jia Li 
Published: October 2023

AbstractSince the release of the Dynamical‐Statistical‐Analog Ensemble Forecast for Landfalling Typhoon Precipitation (DSAEF_LTP) model, a series of upgrades has been made to improve its heavy rainfall forecast performance for different cases and regions of China. However, little effort has been given to systematic evaluation of its multi‐upgraded version with a large sample size, especially for all the coastal regions of China. This study evaluates the performance of Version 1.0 (V1.0) and its improved Version 1.1 (V1.1) of the DSAEF_LTP model in simulating heavy rainfall amounts associated with 76 landfalling tropical cyclones (LTCs) over China during 2004–2016. The optimized schemes from these simulations are then applied to the heavy rainfall forecasts of 37 LTCs during 2017–2020. To further improve the forecast performance of V1.1, a subregional re‐ensemble scheme, referred to as V1.1R, is introduced after examining its performances over three coastal subregions of China. A comparison of the forecast performances of V1.0, V1.1, V1.1R, and four operational numerical weather prediction (NWP) models for the 37 LTCs shows that the performance of V1.1 is much better than that of V1.0, with a 65% higher summed threat score (TS) for over 250‐mm (TS250) and 100‐mm (TS100) rainfall; and that V1.1R's TS100 and TS250 values are further improved by 8% and 20%, respectively, as compared to V1.1. These values are superior to those of the four operational NWP models. Additionally, case studies reveal that the track distributions and intensities of LTCs may significantly impact the forecast performance of heavy rainfall.
An Unprecedented Sea Ice Retreat in the Weddell Sea Driving an Overall Decrease of the Antarctic Sea‐Ice Extent Over the 20th Century
Authors: Dalaiden Quentin , Rezsöhazy Jeanne , Goosse Hugues , Thomas Elizabeth R. , Vladimirova Diana O. , Tetzner Dieter 
Published: October 2023

AbstractSea‐ice extent is predicted to decrease in a warming climate. However, despite global warming over the past century, total Antarctic sea ice remained relatively stable from 1979 until 2015, before strongly melting. Here we explore the long‐term sea ice variability by reconstructing Antarctic sea ice since 1700 CE, based on paleoclimate records and data assimilation. Our results indicate a decline in southern hemisphere sea‐ice extent over the 20th century, driven by a reduction of 0.26 million km2 in the Weddell Sea that reached values at the end of the century lower than any other reconstructed period. The Ross Sea experienced an increasing sea‐ice cover trend due to a low‐pressure system located off the Amundsen Sea coast, offset by a decreasing trend in the Bellingshausen‐Amundsen Sea. Models failed to account for the Ross Sea increase, resulting in an overly uniform estimate of Antarctic sea ice loss over the 20th century.
Large Scale Salinity Anomaly Has Triggered the Recent Decline of Winter Convection in the Greenland Sea
Authors: Almeida Lucas , Kolodziejczyk Nicolas , Lique Camille 
Published: October 2023

AbstractThe Greenland Sea is a key region for open ocean convection and ventilation, which exhibit a large variability with periods of strong convection and shutdowns. After a long period of weak winter convection (from the 1970s to the early 1990s), a recovery has been reported, beginning in the 1990s and intensifying in the early 2000s until 2013. Using ISAS, an optimal interpolation product based on Argo observations, we document a recent significant weakening of deep convection between 2014 and 2020, accompanied by a continuous warming of the mixed layer but also a freshening after 2014. These hydrographic changes likely increase the ocean stratification and precondition the shutdown of winter convection. We suggest that these property changes result from a shift of the large scale atmospheric circulation, affecting the source of Atlantic Water to the Nordic seas, causing a freshening of about −0.1 g kg−1 that spreads into the Greenland Sea.
Deep Short‐Term Slow Slip and Tremor in the Manawatu Region, New Zealand
Authors: Fasola Shannon L. , Jackson Noel M. , Williams Charles A. 
Published: October 2023

AbstractThe Manawatu region experiences deep tremor and long‐term slow slip events (SSEs); however, tremor is adjacent to, and not co‐located with, long‐term SSEs. Observations of episodic tremor and slip (ETS) elsewhere suggest it is possible smaller short‐term SSEs below the current detection threshold occur where tremor is observed. Therefore, we sought to determine if small SSEs occurred with Manawatu tremor. We decomposed GNSS data using times of tremor to assess average surface displacements and performed a static slip inversion to model the displacement during tremor. The slip inversion suggested small slow slip partially coincided with tremor and long‐term SSEs may influence these small SSEs by increasing slip rates. We suggest that the interface below deep long‐term SSEs may slip often, in small ETS‐like SSEs that are not individually detectable geodetically. The question remains as to the nature of the strong variability in SSE behavior with depth and duration in the southern Hikurangi margin.
Time Lags Between Ionospheric Scintillation Detection at Northern Auroral Latitudes and Onset of Geomagnetic Storms
Authors: Yang Zhe , Morton Y. T. Jade , Liu Yunxiang 
Published: October 2023

AbstractIonospheric responses to geomagnetic storms can cause irregular plasma structures and scintillation of Global Navigation Satellite System (GNSS) signals. In this paper, we investigate time lags between the detection of GNSS signal scintillation at northern hemisphere auroral latitudes and the onset of 15 geomagnetic storms that occurred in 2015–2017. The results show that the time lags between the detection of ground‐based GNSS scintillations and the observed sudden change in solar wind parameters are between tens of minutes and 15 hr. This time lag consists of two segments. The first segment is about 30–80 min, which is the lag between observed disturbances in the geomagnetic field and solar wind disturbances detected by orbiting spacecrafts around the L1 point. The second segment is between the observed GNSS signal scintillation and the storm sudden commencement (SSC). This second lag segment varies in the range of about 10–830 min and highly depends on the storm onset time and geomagnetic locations of GNSS signal propagation paths. Longer time lags over 450 min were observed with the signal ionospheric piercing point at 60–70° geomagnetic latitudes (MLAT) on the dayside, while shorter lags of 10∼450 min were observed with the signal IPPs at 68–81° MLAT and on the nightside at the time of SSC. The lag time variations can be explained by ionospheric irregularity production and transport processes associated with a variety of auroral and polar cap phenomena in response to solar wind coupling to the magnetosphere and ionosphere.
3D Crustal Structure of the Jammu and Kashmir Himalaya: Signatures of Mid‐Crustal Ramp and Lesser Himalayan Duplex
Authors: Mitra Supriyo , Sharma Swati , Wanchoo Sunil Kumar , Priestley Keith 
Published: October 2023

AbstractThe NW Himalayan “seismic gap” lies between the 1905 and 2005 earthquake rupture zones and straddles the meisoseismal zone of the 1555‐Kashmir earthquake. Sufficient elastic strain has now accumulated across this region to drive a mega‐thrust earthquake. We model the crustal structure and geometry of the Main Himalayan Thrust (MHT) using Jammu and Kashmir Seismological NETwork data. P‐wave receiver‐function spatial and common‐conversion‐point (CCP) stacks, and joint inversion with Rayleigh‐wave group‐velocities are used to construct 3D Vs model of the region. This model reveals increasing crustal thickness from foreland‐to‐hinterland, and an under‐thrust Indian crust beneath NW Himalaya. The Moho is at ∼45 km depth beneath Sub‐Himalaya deepening to ∼70 km beneath Higher‐to‐Tethyan Himalaya with a gentle NE dip. The MHT forms a low‐velocity layer and has a flat–ramp geometry. The flat segment is beneath Sub‐to‐Lesser Himalaya at 6–10 km depth, and dips ∼4°. The mid‐crustal (frontal) ramp is beneath Kishtwar Higher‐Himalaya and Zanskar Range at 10–16 km depth, and dips ∼13–17°. Crustal structure varies along‐arc between east (Kishtwar) and west (Kashmir Valley) segments. A Lesser Himalayan duplex (LHD) lies beneath the Kishtwar Window and is bound by MHT and Main Central Thrust. The LHD high‐angle imbricate structures are illuminated by moderate seismicity. Beneath Kashmir Valley, the underthrust crust is ∼10 km thicker, has higher crustal Vs, and a shallower MHT at ∼10 km depth. The westward shallowing of MHT occurs through a lateral ramp. Aftershocks of the 2013‐Kishtwar earthquake concentrate on the frontal–lateral ramp intersection and mark the MHT down‐dip locked‐to‐creep transition.
Evaluation and Error Source Analysis of Convection‐Permitting Forecasts for Localized Nocturnal Rainfall Over a Complex Mountainous Region in Pearl River Delta, South China
Authors: Rao Xiaona , Zhu Kefeng , Zhao Kun , Chen Xingchao , Hu Sheng , Liu Xiantong , Zhou Ang 
Published: October 2023

AbstractThe concave mountainous area of Pearl River Delta (PRD) is a summer rainfall hotspot of South China due to the presence of warm‐moist monsoon flow and complex orography. This study evaluated the performance of a convection‐permitting Weather Research and Forecasting (WRF) model in forecasting nocturnal rainfall in this area, focusing on days with low level southwesterly winds during the summers of 2013–2015. Results showed that the nocturnal rainfall exhibited two centers, one located along the large‐scale northern mountains and the other along the small‐scale Huadu Hill. WRF demonstrated superior performance in predicting rainfall over the northern mountainous region. In contrast, WRF significantly underestimated nocturnal rainfall both near local Huadu Hill and in the foothill area of northern mountains, which were strongly influenced by local forcings. Using high‐resolution analyses from Variational Doppler Radar Analysis System (VDRAS) and Automatic Weather Stations observations, we firstly identified the sources of forecast errors in triggering a typical localized nocturnal convection. Results revealed that WRF severely underestimated thermal contrast between the Guangdong‐Hong Kong‐Macao Greater Bay Area urban agglomeration and the concave mountains, leading to the absence of the northeastern/northern inflows toward the cities. Consequently, low level convergence and updrafts near the convection initiation position were too weak to lift air parcels above the severely overestimated level of free convection, thereby failing to trigger the convection. VDRAS‐based sensitivity experiments, with a specific focus on assimilating surface temperature, validated the crucial role of urban‐mountain thermal contrast on local winds that triggered the nocturnal convection.
The Cyclin-dependent kinase 1: more than a cell cycle regulator
Authors: Massacci Giorgia , Perfetto Livia , Sacco Francesca 
Published: October 2023

AbstractThe Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade. From cell cycle control to gene expression regulation and apoptosis, CDK1 is intimately involved in many cellular events that are vital for cell survival. Here, we provide a comprehensive catalogue of the CDK1 upstream regulators and substrates, describing how this kinase is implicated in the control of key ‘cell cycle-unrelated’ biological processes. Finally, we describe how deregulation of CDK1 expression and activation has been closely associated with cancer progression and drug resistance.
HER-3 surface expression increases in advanced colorectal cancer representing a potential therapeutic target
Authors: Capone Emily , Tryggvason Thordur , Cela Ilaria , Dufrusine Beatrice , Pinti Morena , Del Pizzo Francesco , Gunnarsdottir Helga Sigrun , Grottola Tommaso , De Laurenzi Vincenzo , Iacobelli Stefano , Lattanzio Rossano , Sala Gianluca 
Published: October 2023

AbstractHER-3 (also known as ErbB-3) is a human epidermal growth factor receptor tyrosine kinases family member, and its expression in CRC (colorectal cancer) tissues was previously associated with poor prognosis. In this study, HER-3 expression was analyzed by immunohistochemistry in two cohorts of early and advanced metastatic CRC patients. The first cohort included 180 patients diagnosed with CRC in absence of lymph nodes or distant metastases (Stage I and Stage II), while the second was obtained from 53 advanced metastatic CRC patients who developed synchronous (SM) and metachronous (MM) liver metastases. In the first early-stage CRC cohort, 86 out of 180 (47.8%) tumors showed membranous expression of HER-3, with a mean percentage of positive tumor cells of 25.7%; conversely, in advanced metastatic CRC primary tumors, HER-3 was detected in all specimens, with a mean percentage of positive tumor cells of 76.1%. Kaplan–Meier curves showed that in the advanced metastatic CRC group, patients with HER-3high tumors had a significantly lower Cancer-Specific Survival (CSS) rate compared to patients with HER-3low tumors (p = 0.021). Importantly, this worse CSS rate was observed only in the MM subgroup of patients with HER-3high tumors (p = 0.002). Multivariate analysis confirmed that high HER-3 expression represents a significant and strong risk factor for death in patients developing MM liver metastases (Hazard Ratio = 64.9; 95% Confidence Interval, 4.7–886.6; p = 0.002). In addition, using a specific anti-HER-3 antibody-drug conjugate, named EV20/MMAF, we showed that HER-3 + CRC cells can be efficiently targeted in vitro and in vivo. Overall, this study confirms that surface HER-3 is highly expressed in CRC and reveals that HER-3 expression increases in metastatic CRC patients compared to early stage. Importantly, the results suggest that HER-3 has a prognostic and therapeutic value in patients developing MM liver metastases.
Elucidating the active phases of CoOx films on Au(111) in the CO oxidation reaction
Authors: Chen Hao , Falling Lorenz J. , Kersell Heath , Yan George , Zhao Xiao , Oliver-Meseguer Judit , Jaugstetter Max , Nemsak Slavomir , Hunt Adrian , Waluyo Iradwikanari , Ogasawara Hirohito , Bell Alexis T. , Sautet Philippe , Salmeron Miquel 
Published: October 2023

AbstractNoble metals supported on reducible oxides, like CoOx and TiOx, exhibit superior activity in many chemical reactions, but the origin of the increased activity is not well understood. To answer this question we studied thin films of CoOx supported on an Au(111) single crystal surface as a model for the CO oxidation reaction. We show that three reaction regimes exist in response to chemical and topographic restructuring of the CoOx catalyst as a function of reactant gas phase CO/O2 stoichiometry and temperature. Under oxygen-lean conditions and moderate temperatures (≤150 °C), partially oxidized films (CoOx<1) containing Co0 were found to be efficient catalysts. In contrast, stoichiometric CoO films containing only Co2+ form carbonates in the presence of CO that poison the reaction below 300 °C. Under oxygen-rich conditions a more oxidized catalyst phase (CoOx>1) forms containing Co3+ species that are effective in a wide temperature range. Resonant photoemission spectroscopy (ResPES) revealed the unique role of Co3+ sites in catalyzing the CO oxidation. Density function theory (DFT) calculations provided deeper insights into the pathway and free energy barriers for the reactions on these oxide phases. These findings in this work highlight the versatility of catalysts and their evolution to form different active phases, both topological and chemically, in response to reaction conditions exposing a new paradigm in the catalyst structure during operation.
Recent acceleration in global ocean heat accumulation by mode and intermediate waters
Authors: Li Zhi , England Matthew H. , Groeskamp Sjoerd 
Published: October 2023

AbstractThe ocean absorbs >90% of anthropogenic heat in the Earth system, moderating global atmospheric warming. However, it remains unclear how this heat uptake is distributed by basin and across water masses. Here we analyze historical and recent observations to show that ocean heat uptake has accelerated dramatically since the 1990s, nearly doubling during 2010–2020 relative to 1990–2000. Of the total ocean heat uptake over the Argo era 2005–2020, about 89% can be found in global mode and intermediate water layers, spanning both hemispheres and both subtropical and subpolar mode waters. Due to anthropogenic warming, there are significant changes in the volume of these water-mass layers as they warm and freshen. After factoring out volumetric changes, the combined warming of these layers accounts for ~76% of global ocean warming. We further decompose these water-mass layers into regional water masses over the subtropical Pacific and Atlantic Oceans and in the Southern Ocean. This shows that regional mode and intermediate waters are responsible for a disproportionate fraction of total heat uptake compared to their volume, with important implications for understanding ongoing ocean warming, sea-level rise, and climate impacts.
Neural and computational underpinnings of biased confidence in human reinforcement learning
Authors: Ting Chih-Chung , Salem-Garcia Nahuel , Palminteri Stefano , Engelmann Jan B. , Lebreton Maël 
Published: October 2023

AbstractWhile navigating a fundamentally uncertain world, humans and animals constantly evaluate the probability of their decisions, actions or statements being correct. When explicitly elicited, these confidence estimates typically correlates positively with neural activity in a ventromedial-prefrontal (VMPFC) network and negatively in a dorsolateral and dorsomedial prefrontal network. Here, combining fMRI with a reinforcement-learning paradigm, we leverage the fact that humans are more confident in their choices when seeking gains than avoiding losses to reveal a functional dissociation: whereas the dorsal prefrontal network correlates negatively with a condition-specific confidence signal, the VMPFC network positively encodes task-wide confidence signal incorporating the valence-induced bias. Challenging dominant neuro-computational models, we found that decision-related VMPFC activity better correlates with confidence than with option-values inferred from reinforcement-learning models. Altogether, these results identify the VMPFC as a key node in the neuro-computational architecture that builds global feeling-of-confidence signals from latent decision variables and contextual biases during reinforcement-learning.
Atomically precise ultrasmall copper cluster for room-temperature highly regioselective dehydrogenative coupling
Authors: Jia Teng , Li Yi-Xin , Ma Xiao-Hong , Zhang Miao-Miao , Dong Xi-Yan , Ai Jie , Zang Shuang-Quan 
Published: October 2023

AbstractThree-component dehydrogenative coupling reactions represent important and practical methodologies for forging new C–N bonds and C–C bonds. Achieving highly all-in-one dehydrogenative coupling functionalization by a single catalytic system remains a great challenge. Herein, we develop a rigid-flexible-coupled copper cluster [Cu3(NHC)3(PF6)3] (Cu3NC(NHC)) using a tridentate N-heterocyclic carbene ligand. The shell ligand endows Cu3NC(NHC) with dual attributes, including rigidity and flexibility, to improve activity and stability. The Cu3NC(NHC) is applied to catalyze both highly all-in-one dehydrogenative coupling transformations. Mechanistic studies and density functional theory illustrate that the improved regioselectivity is derived from the low energy of ion pair with copper acetylide and endo-iminium ions and the low transition state, which originates from the unique physicochemical properties of the Cu3NC(NHC) catalyst. This work highlights the importance of N-heterocyclic carbene in the modification of copper clusters, providing a new design rule to protect cluster catalytic centers and enhance catalysis.
Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles
Authors: Song Jianwen , Kang Xiaoying , Wang Lu , Ding Dan , Kong Deling , Li Wen , Qi Ji 
Published: October 2023

AbstractThe formation of an occlusive thrombus in the blood vessel is the main culprit for numerous life-threatening cardiovascular diseases that represent the leading cause of morbidity and mortality worldwide. Herein, we develop a polymer nanoplatform that integrates long-wavelength second near-infrared (NIR-II) photoacoustic imaging-based thrombosis detection and antithrombotic activity. We design and synthesize a semiconducting homopolymer with strong absorption in the NIR-II region and molecular motion that boosts photothermal conversion and photoacoustic signal. We dope the homopolymer with a thermosensitive nitric oxide donor to formulate a nanoplatform, on which a fibrin-specific ligand is functionalized to ensure selective thrombus targeting. We show that with strong NIR-II light harvesting capability, bright photoacoustic signal and active thrombus accumulation ability, the NIR-II photoacoustic nanoprobes are able to sensitively and selectively delineate thrombi. We find that the nanoplatform also displays rapid and efficient blood clot removal activity with nearly complete blood flow restoration in both carotid thrombosis models and low extremity arterial thrombosis models under NIR-II light trigger by integrating a thrombus-localized photothermal effect and on-demand nitric oxide release. This nanoplatform offers a versatile approach for the diagnosis and treatment of life-threatening diseases caused by various thrombotic disorders.