bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of immune checkpoint inhibitors and targeted therapies in resected melanoma: a systematic review and network meta-analysis
Authors: Sheng Feng , Yan Yulan , Zeng Baoqi 
Published: November 2023

Background: Multiple immune checkpoint inhibitors (ICIs) and targeted therapies have been widely used as adjuvant treatments for high-risk resected melanoma, with unclear comparative efficacy and safety.Methods: PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov were searched from database inception until 6 June 2023. We included RCTs that assess adjuvant ICIs or targeted therapies in high-risk resected melanoma. Frequentist random-effect network meta-analyses (NMA) were performed. The primary outcome was recurrence-free survival (RFS).Results: Eleven trials including 10,712 patients and comparing 10 treatments (nivolumab [Nivo], ipilimumab 3 mg/kg [Ipi3], Ipi10, pembrolizumab [Pemb], vemurafenib [Vemu], bevacizumab [Beva], Nivo + Ipi1, Nivo + Ipi3, dabrafenib plus trametinib [Dab + Tram], and placebo/observation [Pla/Obs]) were included. NMA showed that all treatments showed RFS benefit over placebo/observation except Ipi3 (hazard ratio [HR], 0.78; 95% CI, 0.58–1.05). Combination therapy of Nivo + Ipi3 was the most effective treatment, which significantly improved RFS compared with other treatments. NMA also showed that all treatments were associated with an increased risk of grade 3-5 adverse events over placebo/observation except Nivo (HR, 1.25; 95% CI, 0.87–1.80). NMA suggested that Nivo and Pemb were the two safest treatments except for placebo/observation. Although three combination therapies ranked as the top three in terms of RFS, they did not show significant overall survival benefits compared to monotherapies including Pemb, Nivo, Ipi3, and Ipi10.Conclusion: In this NMA, adjuvant Nivo and Pemb are the preferred options in patients with resected melanoma considering the benefits and harms. Combination therapy of Nivo + Ipi3 may be a promising strategy, but more evidence from phase 3 trials is needed.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=438667, PROSPERO (CRD42023438667).
Lektura immersyjna e-literatury
Authors: Bodzioch-Bryła Bogusława 
Published: November 2023

Tekst przybliża związki między stosowaną przez twórców e-literatury strategią przepływu (flow) a immersyjnością utworu. Kategoria flow odnosi się do dzieł procesualnych, stwarzających wrażenie stopniowego bądź dynamicznego „płynięcia” po ekranie oraz płynnego przeobrażania się. Celem jej stosowania zwykle jest konstruowanie warstwy ikonicznej lub budowanie dynamiki ścieżki e-utworu. Immersyjność zaś to wytwarzająca się pomiędzy odbiorcą-interaktorem a e-utworem chęć/zgoda na podtrzymywanie w świadomości wrażenia przebywania (percepcyjnego i interpretacyjnego zanurzenia i zaangażowania) we wnętrzu innej, wirtualnej rzeczywistości. Najsilniejsze wrażenie immersji gwarantują utwory realizowane z wykorzystaniem środowiska CAVE (jaskini wirtualnej), choć immersja możliwa jest również w przypadku e-literatury mniej zaawansowanej technologicznie, poziomy lektury immersyjnej wynikają bowiem z łączenia przez twórców w rozmaitych konfiguracjach elementów takich jak: uprzestrzennienie, warstwa kolorystyczno-graficzna eksponująca procesualność lub efekt głębi, warstwa brzmieniowa, nakłanianie odbiorcy do wejścia w rolę interaktora itp. Badacze na immersyjność e-literatury spoglądają jako na artystyczną manifestację sprzeciwu wobec postawy chłodnego eksperckiego dystansu, dominującego w dwudziestowiecznym historyczno- i krytycznoliterackim dyskursie uniwersyteckim. Immersję postrzegać więc można jako rodzaj „mostu” gwarantującego zaangażowanie w lekturę, szansę odzyskania utraconego zaangażowania odbiorczego.
Aimery de Nabinaud, OFM (†1326), Counsellor of Henry II, Bishop of Paphos, Papal Diplomat between Cyprus and Armenia, and Debtor
Authors: Schabel Christopher 
Published: November 2023

Of the four medieval cities (and dioceses) of Frankish Cyprus – Nicosia, Paphos, Limassol, and Famagusta – Paphos has received the least attention. Continuing work on the Bullarium Cyprium project, which involves editing the papal letters referring to the island, provides a window into the ecclesiastical history of the town. This is the second of three articles in this journal that complete Jean Richard’s work on the bishops of Paphos in the period of the Avignon papacy (1309–1377). With some notes on Bishop Jacques More (1309–1321), this paper focuses on his successor, Aimery de Nabinaud, OFM, the first member of an illustrious family of ecclesiastics who served Cyprus in the 14th century. First noted in 1310, when he was teaching at the Minorite convent in Famagusta, Aimery was an important advisor to King Henry II (†1324), he was eventually elevated to Bishop of Paphos in 1322. We know most about Aimery’s diplomatic activities with the Kingdom of Armenia in Cilicia from 1310 until his death, as well as the difficult financial situation he left to his successor as bishop, Géraud de Veyrines.
O pewnym sposobie posługiwania się klasycyzmem w europejskiej kulturze artystycznej
Authors: Cebula Łukasz 
Published: November 2023

Celem głównym niniejszego artykułu jest kulturoznawcza analiza strategii malarskiej Aleksieja Wenecjanowa w odniesieniu do zagadnienia tematu chłopskiego w malarstwie. Problematyka ta wiąże się z kolei z określonym sposobem posługiwania się klasycyzmem. Klasycyzm interpretowany jest tutaj nie tylko jako pewien nurt stylistyczny bądź epoka w dziejach sztuki, lecz również jako zestaw reguł i wartości, które przynależą do wyposażenia umysłowego działającego artysty. Celem pobocznym jest wskazanie na inne przykłady analogicznych strategii zaczerpniętych z dziejów europejskiej kultury artystycznej, wskazujących na istnienie pewnej ciągłości intelektualnej w historii kultury europejskiej.
Pengaruh Tarif Pajak dan Pengetahuan Wajib Pajak Terhadap Kepatuhan Wajib Pajak Kendaraan Bermotor di Kota Bandar Lampung (Studi pada Kantor Samsat Rajabasa Bandar Lampung)
Authors: Putri Geo Vany Edy , Rizal Syamsu 
Published: November 2023

Motor vehicle tax (PKB) is a form of tax levied on the ownership and/or ownership of motor vehicles, with natural or legal persons as owners of the vehicles being tax payers. Tax awareness becomes important when taxpayers have enough knowledge and understanding of the tax system. This encourages them to voluntarily fulfill their tax payment obligations. The higher a taxpayer's level of tax awareness, the higher their level of tax compliance, while also reinforcing their role as a good citizen. This study aims to determine the influence of tax rates and taxpayer knowledge on the compliance level of automobile taxpayers in Bandar Lampung City. The research method used was quantitative research in the tax-paying population of Bandar Lampung City. A sample of 100 respondents was selected using purposive sampling with calculations using the Slovin formula. Data was collected through document review, documentation, observations, interviews, and questionnaires. Data analysis included several linear regression tests, correlation coefficient tests, t-tests, F-tests, and R2 tests. The study results showed that tax rate and taxpayer knowledge had a significant influence of 47.5% on vehicle tax payment compliance of taxpayers at Samsat office in Bandar Lampung Rajabasa. At the same time, other factors not considered in this study also affect 52.5% of taxpayer compliance. This study highlights the importance of improving taxpayers' knowledge and understanding of the tax system as well as reviewing tax rates to increase tax compliance levels.
ЕКЗИСТЕНЦІЙНІ МОТИВИ АНТИВОЄННОЇ ЛІРИКИ ХХ СТ.: АВТОРСЬКІ МОДЕЛІ
Authors: Бадалов Максим , Гальчук Оксана 
Published: November 2023

У статті проаналізовано поетичні твори антивоєнного спрямування Р. Кіплінга, Б. Брехта і П. Целана в контексті філософії екзистенціалізму. Виокремлено основні мотиви та образи, що використовують поети для моделювання антимілітарного дискурсу. Сформульовано ключові атрибути авторської антивоєнної концептопоетики, питомі для різних моделей художнього екзистенціалізму – танатологічної (Р. Кіплінг), рефлексивної (Б. Брехт), інтертекстуальної (П. Целан).
FEATURES OF THE CONSTRUCTION OF THE INTERMEDIATE FREQUENCY PATHSUPERHETERODYNE RADIO RECEIVER WITH DIGITAL SIGNA PROCESSING
Authors: Гревцев А.И. , Зимарин В.И. , Капитанов В.В. 
Published: November 2023

при проектировании приемного тракта промежуточной частоты супергетеродинного радиоприемника с цифровой обработкой сигналов применительно к узкополосным сигналам возникает необходимость учета особенностей выбора номинального значения промежуточной частоты и дискретизации не только полезного сигнала, но и всех помеховых частотных составляющих, поступающих на вход аналого-цифрового преобразователя. Целью работы является разработка предложений по построению тракта промежуточной частоты супергетеродинного радиоприемника с цифровой обработкой сигналов, учитывающих ослабление нежелательных частотных составляющих ближайшего отображения спектра при аналого-цифровом преобразовании сигнала. Элементами новизны является подход к выбору номинального значения промежуточной частоты и определение требований к минимальному значению ширины полосы мешания антиалиасингового фильтра. В работе показано, каким образом на этапе проектирования осуществляется предварительный выбор структуры тракта промежуточной частоты, определяется номинальное значение промежуточной частоты, выбирается антиалиасинговый полосовой фильтр, обеспечивающий ослабление нежелательных составляющих спектра в соседних каналах приема и в пределах отображения размноженного спектра при аналого-цифровом преобразовании сигнала. Предложенный подход позволяет сформировать структурную схему тракта второй промежуточной частоты и предъявить требования к его функциональным элементам
when designing the receiving path of the intermediate frequency of a superheterodyne radio receiver with digital signal processing in relation to narrowband signals, it becomes necessary to take into account the features of choosing the nominal value of the intermediate frequency and sampling not only the useful signal, but also all the interfering frequency components coming to the input of the analog-to-digital converter. The aim of the work is to develop proposals for constructing an intermediate frequency path of a superheterodyne radio receiver with digital signal processing, taking into account the attenuation of undesirable frequency components of the nearest spectrum display during analog-to-digital signal conversion. The novelty elements are the approach to choosing the nominal value of the intermediate frequency and determining the requirements for the minimum value of the interference bandwidth of the antialiasing filter. The paper shows how, at the design stage, a preliminary selection of the structure of the intermediate frequency path is carried out, the nominal value of the intermediate frequency is determined, an antialiasing bandpass filter is selected, which provides attenuation of undesirable components of the spectrum in neighboring reception channels and within the display of the multiplied spectrum during analog-to-digital signal conversion. The proposed approach makes it possible to form a block diagram of the second intermediate frequency path and to make requirements for its functional elements
METHOD FOR SIMULATING MAGNETIC FIELD RADIATIONS OF RADIO ELECTRONIC EQUIPMENT IN NEAR FIELDS
Authors: Глотов В.В. , Семейкин И.В. , Рудь А.Е. 
Published: November 2023

представлен алгоритм моделирования источников электромагнитных помех с помощью измерений, выполненных в ближней зоне магнитного поля, излучаемого силовым электронным оборудованием. Данный вид измерений происходит на внутриаппаратурном уровне электромагнитной совместимости. Для прогнозирования излучаемого магнитного поля разработана модель, основанная на элементарных магнитных диполях. Эта модель получена на основе измерений в ближнем поле. Для определения параметров модели используется процедура оптимизации в сочетании с матричной инверсией. В отличие от стандартных подходов, новая методика позволяет находить эквивалентные источники излучений с небольшим числом диполей за наименьшее время вычислений. Продемонстрировано экспериментальное исследование разработанной методики, проведено сравнение полученных результатов с классическим методом, а именно с помощью аппаратно-программного комплекса сканирования ближнего электромагнитного поля. Для экспериментальной проверки этого метода проводятся магнитные измерения в ближнем поле для нахождения эквивалентной модели в случае одновитковой катушки, тороидальной катушки и DC/DC-преобразователя. Результаты, полученные с помощью разработанной методики, имеют погрешность относительно сканера ближнего поля около 10%, что является хорошим показателем для внедрения ее в промышленность
the article presents an algorithm for modeling sources of electromagnetic interference using measurements made in the near field of the magnetic field emitted by power electronic equipment. This type of measurement occurs at the intra-hardware level of electromagnetic compatibility. To predict the emitted magnetic field, a model based on elementary magnetic dipoles has been developed. This model is derived from near-field measurements. To determine the model parameters, an optimization procedure is used in combination with matrix inversion. Unlike standard approaches, the new technique makes it possible to find equivalent radiation sources with a small number of dipoles in the shortest computation time. The article also demonstrates an experimental study of the developed technique and compares the results obtained with the classical method, namely using a hardware-software complex for scanning a near electromagnetic field. To experimentally test this method, magnetic measurements are carried out in the near field to find an equivalent model in the case of a single-turn coil, a toroidal coil and a DC/DC converter. The results obtained using the developed technique have an error relative to the near-field scanner of about 10%, which is a good indicator for its implementation in industry
IKT bei Freiburger Lehrpersonen: Informatikkenntnisse und Integrationsstufe
Authors: Schumacher Jérôme A. , Coen  Pierre-François 
Published: November 2023

In diesem Beitrag werden die Ergebnisse einer Studie der Pädagogischen Hochschule Freiburg vorgestellt. Untersucht wurden die Informatikkenntnisse sowie die Verwendung von IKT im Unterrichtskontext bei Freiburger Lehrpersonen vom Kindergarten bis zur Sekundarstufe II. In einem ersten Schritt wird die Bedeutung der IKT-Integration als innovative Praxis dargelegt, ein Integrationsmodell vorgestellt sowie der Begriff der Informatikkenntnisse (alphabétisation informatique) erläutert. Im zweiten Teil werden die Messinstrumente sowie die wesentlichen Ergebnisse präsentiert. Abschliessend werden einige Überlegungen und Vorschläge zur Aus- und Weiterbildung von Lehrpersonen in Bezug auf die IKT-Integration dargelegt.
PROTOTYPE OF INSPECTION EXHAUST BRAKE VEHICLE BASED MICROCONTROLLER
Authors: Pramudi Setia Hadi , Abdillah Dzikri Putra , Wibowo Helmi , Suartika I Made 
Published: November 2023

Technical requirement checking relating exhaust brake on vehicle inspection is still lacking because there is no additional equipment which can helps to ensure the exhaust brake works. From that case a set of research is conducted to help inspectors to ensure the exhaust brake works normallyÂ by using microcontroller based prototype. This research aims to design and implement the inspect equipment of exhaust brake using sound sensor DFr and air Sensor. The process requires 3 inspectors and by using this tool, inspectors could ensure the exhaust brake works or not for hino vehicle. This research shows that measuring by using this auxiliary tool for checking the exhaust brake could inform the fluctuation of sound produced by vehicle machine and decreasing air on exhaust brake system. The result of its prototype testing, the sound sensor is able to detect the increasing of sound and if the sound level reaches 80 dB, there will be a green as warning LED and l2c LCD displays the noise level and the prototype could works properly, the accuracy percentage is 97% and for the air Sensorâ€™s accuracy is 92%
The Relation of Students Knowledge About Potential Chemical Hazards with Work Accidents in the Chemistry Laboratory of the Department of Nutrition, Health Polytechnic, Ministry of Health, Palangka Raya
Authors: SY Yetti Wira Citerawati , Hidayatulloh Agus , Sukrianur Ahmad 
Published: November 2023

A chemistry laboratory is a place that has the potential to pose a danger to students during practicum. One factor that influences the incidence of work accidents in educational laboratories is student knowledge, especially about potential chemical hazards. This study aims to determine the relationship between students’ knowledge about potential chemical hazards With Accident events Work In The Chemistry Laboratory Of The Department Of Nutrition, Health Polytechnic, Ministry Of Health, Palangka Raya. This research is a type of quantitative research, the analytic observation method with a cross-sectional design. Sampling using a total sampling technique. The instrument for measuring knowledge and the incidence of work accidents is in the form of a questionnaire and has been tested for validity and reliability. The data obtained were analyzed by chi-square test with a significance level of 95%. The sample in this study was 73 respondents 17-24 years old with a gender distribution of 9 (12%) males and 64 (88%) females. The range of knowledge scores is a minimum of 25 and a maximum of 90, the median is 70 and the mean is 67.4. The level of knowledge is 40 (54.8%) good and 33 (45.2%) less. Based on the results of the study, as many as 26 respondents (35,6%) had experienced work accidents and as many as 47 respondents (64.4%) had never had work accidents. The chi-square statistical test results showed no relationship between student knowledge of potential chemical hazards and accident events in chemistry laboratories. The conclusion of this research is that there was not a relationship between student knowledge of potential chemical hazards with accident events Work in chemistry laboratories of the Nutrition Department of the Health Polytechnic of the Ministry of Health, Palangka Raya. Further research should be carried out regarding other variables that influence the incidence of work accidents in chemical laboratories.
Investigating Communication in Long- Distance Romantic Relationships in the English-Speaking Caribbean Using a Mixed-Methods Approach
Authors: McConney Danielle N. , Steele Godfrey A. 
Published: November 2023

Interpersonal communication in long-distance romantic relationships (LDRRs) in the English-speaking Caribbean is relatively understudied. This type of romantic relationship is growing globally; however, the rate of acknowledgement, recognition and respect is lagging regionally. This bars LDRRs from ready inclusion in a more diverse social landscape. Studies on LDRR communication have gained some traction (Steele and McConney 2020a, 2020b), but overall, the Anglophone Caribbean is underrepresented in this body of LDRR research. Because of the lack of understanding surrounding how people in contemporary Caribbean society communicate in LDRRs, to learn more, we need to look at how they communicate. Discussing and understanding the communication dimension in LDRRs can lead to recommendations on how to navigate these relationships. As such, a framework of interpersonal romantic relationships was used to examine how the variables of computer-mediated communication, attachment styles, social media and emotional intelligence may contribute to LDRR communication. The objective of this study explores the behaviour of the aforementioned variables in an LDRR context, utilizing a mixed-methods approach: a deep dive into the relationships of five resilient couples via qualitative data collection of semistructured individual interviews and journaling exercises. This smaller purposive population sampling was followed by the conceptual phase two – survey development. Quantitative data obtained from the developed questionnaire were sourced from a wider LDRR audience to analyse their attachment styles and emotional intelligence. Phase four interprets the qualitative and quantitative data sets. Attachment Style Theory, Relational Dialectics Theory and Grounded Theory undergird the theoretical framework along with dialectical pluralism (Johnson 2017). The study sought to answer RQ1: How do social media and computer-mediated communication affect communication patterns in long-distance romantic relationships? RQ2: How does attachment style account for computer-mediated communication choices in these relationships? RQ3: What are the significant effects of emotional intelligence on interpersonal communication patterns in long-distance romantic relationships?
Position of the Russian periodical press at the beginning of the 20th century estimated by «The Times»
Authors: Antonova Lidia 
Published: November 2023

At the turn of the XIX–XX centuries periodical press is becoming more and more popular. Its influence on public opinion, the course of domestic political processes and even the development of international relations is increasing. The press becomes an instrument of state policy in the formation of positive, friendly or negative, hostile images of the allies and rivals. At the same time, the content of national newspapers and magazines is under close attention not only of the domestic audience, but also of the foreign ones. Thus, the leading British newspaper «The Times» regularly analyzes the publications of foreign periodicals, including Russian. In this regard, the general assessment given by «The Times» to the position of the Russian press, the impact of censorship restrictions on it, its representativeness as a mirror of public opinion and a translator of the government position becomes interesting.
The article concludes that the Russian press was carefully read in Britain. «The Times» was quick to note the Anglophobia or the opposite friendly disposition of Russian newspapers. At the same time, the Russian press was considered biased, tendentious, not reflecting an objective picture of public opinion. The attitude of «The Times» is changing as the British image transforms in Russian periodicals. The change in rhetoric from hostile to allied occurs in the periodicals of both countries during the Anglo-Russian rapprochement and the formation of the Triple Entente.