bluuebunny/crossref_metadata_2025_split huggingface dataset:
DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2
Authors: Kaarijärvi Roosa , Kaljunen Heidi , Nappi Lucia , Fazli Ladan , Kung Sonia H. Y. , Hartikainen Jaana M. , Paakinaho Ville , Capra Janne , Rilla Kirsi , Malinen Marjo , Mäkinen Petri I. , Ylä-Herttuala Seppo , Zoubeidi Amina , Wang Yuzhuo , Gleave Martin E. , Hiltunen Mikko , Ketola Kirsi 
Published: January 2024

AbstractTreatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of castration-resistant prostate cancer resistant to androgen receptor (AR) inhibitors. Our study unveils that AR suppresses the neuronal development protein dihydropyrimidinase-related protein 5 (DPYSL5), providing a mechanism for neuroendocrine transformation under androgen deprivation therapy. Our unique CRPC-NEPC cohort, comprising 135 patient tumor samples, including 55 t-NEPC patient samples, exhibits a high expression of DPYSL5 in t-NEPC patient tumors. DPYSL5 correlates with neuroendocrine-related markers and inversely with AR and PSA. DPYSL5 overexpression in prostate cancer cells induces a neuron-like phenotype, enhances invasion, proliferation, and upregulates stemness and neuroendocrine-related markers. Mechanistically, DPYSL5 promotes prostate cancer cell plasticity via EZH2-mediated PRC2 activation. Depletion of DPYSL5 decreases proliferation, induces G1 phase cell cycle arrest, reverses neuroendocrine phenotype, and upregulates luminal genes. In conclusion, DPYSL5 plays a critical role in regulating prostate cancer cell plasticity, and we propose the AR/DPYSL5/EZH2/PRC2 axis as a driver of t-NEPC progression.
MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response
Authors: Ma Wenjuan , Ahmad Shah Adil Ishtiyaq , Hashimoto Michihiro , Khalilnezhad Ahad , Kataoka Miho , Arima Yuichiro , Tanaka Yosuke , Yanagi Shigeru , Umemoto Terumasa , Suda Toshio 
Published: January 2024

AbstractHematopoietic stem cell (HSC) divisional fate and function are determined by cellular metabolism, yet the contribution of specific cellular organelles and metabolic pathways to blood maintenance and stress-induced responses in the bone marrow remains poorly understood. The outer mitochondrial membrane-localized E3 ubiquitin ligase MITOL/MARCHF5 (encoded by the Mitol gene) is known to regulate mitochondrial and endoplasmic reticulum (ER) interaction and to promote cell survival. Here, we investigated the functional involvement of MITOL in HSC maintenance by generating MX1-cre inducible Mitol knockout mice. MITOL deletion in the bone marrow resulted in HSC exhaustion and impairment of bone marrow reconstitution capability in vivo. Interestingly, MITOL loss did not induce major mitochondrial dysfunction in hematopoietic stem and progenitor cells. In contrast, MITOL deletion induced prolonged ER stress in HSCs, which triggered cellular apoptosis regulated by IRE1α. In line, dampening of ER stress signaling by IRE1α inihibitor KIRA6 partially rescued apoptosis of long-term-reconstituting HSC. In summary, our observations indicate that MITOL is a principal regulator of hematopoietic homeostasis and protects blood stem cells from cell death through its function in ER stress signaling.
Novel Association of KLRC4-KLRK1 Gene Polymorphisms with
Susceptibility and Progression of Antithyroid Drug-Induced
Agranulocytosis
Authors: He Yayi , Ma Pan , Luo Yuanlin , Gong Xiaojuan , Gao Jiayang , Sun Yuxin , Chen Pu , Zhang Suliang , Tian Yuxin , Shi Bingyin , Zhang Bao 
Published: January 2024

Abstract
Objective Antithyroid drug (ATD)-induced agranulocytosis (TIA) is the most
serious adverse effect during ATD treatment of Graves’ disease (GD).
Previously, the MICA gene was reported to be associated with TIA.
MICA protein is an important ligand for the NKG2D protein, which is
encoded by the KLRK1 gene and KLRC4-KLRK1 read-through
transcription. This study further investigated the association between
KLRC4-KLRK1 gene polymorphisms and susceptibility to TIA.
Methods Twenty-eight candidate single nucleotide polymorphisms (SNPs) on
KLRC4-KLRK1 read-through transcription were evaluated by the iPLEX
MassARRAY system in 209 GD control patients and 38 TIA cases.
Results A significant association of rs2734565 polymorphism with TIA was
found (p=0.02, OR=1.80, 95%
CI=1.09–2.96). The haplotype C-A-A-C-G, including rs2734565-C,
was associated with a significantly higher risk of TIA (p=4.79E-09,
OR=8.361, 95% CI=3.737–18.707). In addition, the
interval time from hyperthyroidism to agranulocytosis onset was shorter in
patients carrying the rs2734565-C allele than in non-carrying groups (45.00
(14.00–6570.00) d vs. 1080.00 (30.00–3600.00) d,
p=0.046), and the interval from ATD treatment to
agranulocytosis onset was also shorter in patients carrying rs2734565-C allele
(29.00 (13.00–75.00) d vs. 57.50 (21.00–240.00) d,
p=0.023).
Conclusions The findings suggest that the KLRC4-KLRK1 gene
polymorphism is associated with susceptibility and progression of ATD-induced
agranulocytosis. Patients carrying the rs2734565-C allele had a higher
susceptibility and faster onset time of TIA.
Meanings and implications of love: review of the scholarship of love with a sub-Saharan focus
Authors: Steen Karin , Antoniou Alice , Lindemann Lehnke , Jerneck Anne 
Published: January 2024

AbstractLove, as an emotion, binds people together in social practices that are contingent on culture, historical processes, and social trends. As such, love is a perfect site to study how people interact and to understand how power, equality, and sustainability play out in human relations. Despite its importance and much attention, love as a concept and form of interaction is not fully understood, especially not across cultures. In our research, mainly in sub-Saharan Africa, we show that alongside other emotions, love matters not only for passion in life or for wellbeing but also for improved resource use, increased gender equality, and, subsequently, higher food security and sovereignty – all signs of sustainability. While love is understood as a universal human phenomenon, definitions and expressions of love vary across time and cultures. Since love drives human interaction in many intertwined ways there is no single best way to define it. Yet, scholars have advanced the theory of love by identifying at least 40 major distinct but interdependent ‘love constructs’ fitting into the four main dimensions of affection, closeness, compassion, and commitment (Karandashev et al. 2022). In parallel to this and based on our review of the scholarship of love in a subset of 45 relevant academic articles from an 80-article systematic literature search of ‘love’ we find four core (and partly overlapping) types of how to speak about love as an expression and experience. These include: 1/ contextual love influenced by culture, space, and time; 2/ romantic and compassionate love; 3/ transactional love; 4/ post-humanist perspectives and ‘harmony love’. Finally, we examine love in relation to power; love-related emotions; and how understandings of love and culture impact gender relations.
How did African stock markets react to the Russia-Ukraine crisis “black-swan” event? Empirical insights from event study
Authors: Oyadeyi Olajide O. , Arogundade Sodiq , Biyase Mduduzi 
Published: January 2024

AbstractThis study builds on the recent literature by investigating how various types of African stock markets responded to the Russia-Ukraine crisis (commonly referred to as the black-swan event). The empirical analysis used in this paper centred on event study analysis, a statistical technique used to measure the impact of a specific event. The findings show that the black-swan event had a significant negative impact on African stock markets (14/20), with stocks having a negative abnormal return on the event day, and out of this, nine stocks’ abnormal returns are statistically significant. These include Safaricom Kenya, Commercial International Bank, Attijariwafa Bank, Morocco Casablanca Index, Egyptian Exchange 30, Nairobi All Share Index, AVI Equity, MCB Group Ltd, FTSE/JSE All Share, Delta Corp. Ltd, Stock Exchange of Mauritius, Tunisia Stock Exchange, Tanzania All Share Index, and Banque de Tunisie. Furthermore, the study discovers that African stock markets reacted heterogeneously to the impact of the crises, while some stocks were severely affected, some were minimally affected. The study concludes that African stock markets should build a resilient market capable of withstanding external shock and reducing the risk of contagion.
Dynamics of returns to vocational education in China: 2010–2017
Authors: Chen Jie , Pastore Francesco 
Published: January 2024

AbstractIn this paper, we use the Chinese General Social Survey data (2010–2017) to analyze the dynamics of returns to different education qualifications. We find increasing returns for all types of education, with returns to vocational and academic education increasing roughly at the same speed. We additionally compare the returns to vocational education with returns to academic education. Compared to those who only complete compulsory education, upper secondary graduates earn about 20% more, vocational college graduates earn 50%, and academic university graduates earn 75% more. At tertiary level, academic education pays better than vocational education, although the difference shrinks over the years. At upper secondary level, the evidence is indeterminate, depending on different econometric techniques (i.e., OLS, IV, Lewbel method, or PSM). These findings add to the limited quantitative evidence on returns to vocational education. The dynamics emerged from the findings echo the discussion on labor market mismatch and overeducation in China, which has important policy implications.
Looking towards an automated future: U.S. attitudes towards future artificial intelligence instantiations and their effect
Authors: Novozhilova Ekaterina , Mays Kate , Katz James E. 
Published: January 2024

AbstractThe present study explores people’s attitudes towards an assortment of occupations on high and low-likelihood of automation probability. An omnibus survey (N = 1150) was conducted to measure attitudes about various emerging technologies, as well as demographic and individual traits. The results showed that respondents were not very comfortable with AI’s management across domains. To some degree, levels of comfort corresponded with the likelihood of automation probability, though some domains diverged from this pattern. Demographic traits explained the most variance in comfort with AI revealing that men and those with higher perceived technology competence were more comfortable with AI management in every domain. With the exception of personal assistance, those with lower internal locus of control were more comfortable with AI managing in almost every domain. Age, education, and employment showed little influence on comfort levels. The present study demonstrates a more holistic approach of assessing attitudes toward AI management at work. By incorporating demographic and self-efficacy variables, our research revealed that AI systems are perceived differently compared to other recent technological innovations.
The impact of artificial intelligence on employment: the role of virtual agglomeration
Authors: Shen Yang , Zhang Xiuwu 
Published: January 2024

AbstractSustainable Development Goal 8 proposes the promotion of full and productive employment for all. Intelligent production factors, such as robots, the Internet of Things, and extensive data analysis, are reshaping the dynamics of labour supply and demand. In China, which is a developing country with a large population and labour force, analysing the impact of artificial intelligence technology on the labour market is of particular importance. Based on panel data from 30 provinces in China from 2006 to 2020, a two-way fixed-effect model and the two-stage least squares method are used to analyse the impact of AI on employment and to assess its heterogeneity. The introduction and installation of artificial intelligence technology as represented by industrial robots in Chinese enterprises has increased the number of jobs. The results of some mechanism studies show that the increase of labour productivity, the deepening of capital and the refinement of the division of labour that has been introduced into industrial enterprises through the introduction of robotics have successfully mitigated the damaging impact of the adoption of robot technology on employment. Rather than the traditional perceptions of robotics crowding out labour jobs, the overall impact on the labour market has exerted a promotional effect. The positive effect of artificial intelligence on employment exhibits an inevitable heterogeneity, and it serves to relatively improves the job share of women and workers in labour-intensive industries. Mechanism research has shown that virtual agglomeration, which evolved from traditional industrial agglomeration in the era of the digital economy, is an important channel for increasing employment. The findings of this study contribute to the understanding of the impact of modern digital technologies on the well-being of people in developing countries. To give full play to the positive role of artificial intelligence technology in employment, we should improve the social security system, accelerate the process of developing high-end domestic robots and deepen the reform of the education and training system.
Machine learning based longitudinal virtual diagnostics at SwissFEL
Authors: Bettoni S. , Orlandi G. L. , Salomone F. , Boiger R. , Ischebeck R. , Xue R. , Mostacci A. 
Published: January 2024

The bunch length in a linac driven Free Electron Laser (FEL) is a major parameter to be characterized to optimize the final accelerator performance. In linear machines, this observable is typically determined from the beam imaged on a screen located downstream of a Transverse Deflecting Structure (TDS) used to impinge a time dependent kick along the longitudinal coordinate of the beam. This measurement is typically performed during the machine setup and only sporadically to check the beam duration, but it cannot be continuously repeated because it is time consuming and invasive. A non-invasive method to determine the electron bunch length has already been presented in the past. This method is based on the analysis of the synchrotron radiation light spot emitted by the bunch passing through a magnetic chicane, provided that the energy chirp impinged on the bunch by the upstream radio frequency structures is known. In order to overcome a systematic discrepancy affecting the synchrotron radiation monitor based results compared to the absolute TDS based ones, we implemented and optimized a machine learning approach to predict the bunch length downstream of the two SwissFEL compression stages—from about 10 fs up to about 2 ps—as well as the beam longitudinal profile at the first one.
Fabrication of compact circular ring antenna loaded with Gd-YIG ferrites: Photon–magnon interaction
Authors: Yadav Sheetal , Sharma Monika , Kuanr Bijoy K. 
Published: January 2024

In telecommunications technology, transmitting and receiving signals is not possible without an integrated antenna. Recently, novel approaches of transmitting and receiving signals using advancement in quantum technology as “information coherent transfer” have been emphasized which overcomes the limitations of superconducting qubits. In the present investigation, a compact-sized circular-ring antenna was designed for a 12 GHz centre frequency. The antenna was topped with Gd(x)-doped YIG (x = 0.0, 0.1, 0.2, 0.3) thin disks to investigate its tunable operation over the tri-band (C to Ku) frequencies due to the photon–magnon coupling, which enables coherent qubit information transmission from an electromagnetic (EM) carrier to the magnons. The proposed prototype of the antenna is validated using HFSS simulation. To characterize the frequency tunability of the designed antenna, we measured the return loss (S11) via a vector network analyzer as a function of dc magnetic field. Different concentrations of Gd-doped YIG ferrites (Gdx-YIG) have been loaded on ring antennas to observe strong anti-crossing phenomena with the application of an external magnetic field. The designed antenna has a tunability of around 300% for a small applied magnetic field up to 3.7 kOe. The maximum gain of dual resonance antenna is 1.4 for higher magnetic field of 3.7 kOe. The highest efficiency and lowest bandwidth of 30% and 14% respectively, for Gd0.1-YIG disk are observed. The measured normal mode splitting spectrum as a function of bias magnetic field that gives the maximum coupling strength is 153 MHz for a Gd concentration of 0.1. For practical applications, such antennas are suitable for use in tunable tri-band or multi-band applications (C to Ku).
An exploratory study of intonational variation in L1 and L2 English speakers’ pragmatic production of high imposition
requests and refusals
Authors: Kostromitina Maria 
Published: January 2024

Abstract
This exploratory study examined the intonational patterns and corresponding speech act strategies in L1 and L2
English speakers’ production of high imposition requests and refusals that were elicited using video-based multiple turn discourse
completion tasks (DCTs). The participants, 34 L1 American English speakers and 14 high-proficiency L2 English speakers, recorded
their oral responses to 10 multiple-turn video-based DCTs. Using Brazil’s (1997)
framework, the collected speech samples were analyzed for tone choices in each tone unit. Pragmatic strategies in the produced
speech acts were analyzed by adapting the existing coding frameworks (Beebe et al.,
1990; Blum-Kulka et al., 1989). The extracted tone choices and
lexico-mathematical strategies were compared between the two language groups. The results preliminarily revealed differences in
the use of tones by L1 and L2 English speakers in performing requests and refusals. Moreover, while the employed speech act
strategies were largely similar between the two speaker groups, the associated tone choices showed contrasting usage patterns.
Measuring gloss using spectral reflectance
Authors: Zarobila Clarence J , Nadal Maria E , Miller C Cameron 
Published: January 2024

Abstract
Gloss is historically measured at three angles of incidence, 20°, 60°, and 85°, using a light source filtered to replicate Illuminant C and a colored glass filter designed to reproduce the CIE 1931 photopic luminous efficiency function. Herein an alternate method that relies on the spectral reflectance of a gloss standard and the sample, both measured with a new reference gonio-spectrometer and in accordance with the geometries specified in internationally recognized standards, is presented. The spectral reflectance measured with the aid of a spectrometer is converted to luminous flux which is then used to calculate gloss. This alternate method eliminates the errors associated with the source actual spectral power distribution vs. that of Illuminant C, and the actual spectral transmittance of the colored glass filter used vs. the spectral distribution of the photopic luminous efficiency function. Gloss measurement results for a synthetic quartz sample, Suprasil 311, are presented. The measured values averaged over three reflectance measurements are 71.3 ± 1.2 (k = 2), 82.2 ± 0.9 (k = 2), and 98.1 ± 3.0 (k = 2), and these agree exceptionally well with the theoretical values of 71.3, 82.1, and 98.1 Gloss Units at 20°, 60°, and 85°, respectively. Components of uncertainty are discussed. In addition, a gloss scale is proposed. The components of the scale have been selected from readily available optical glass types for ease of fabrication and relatively low cost. They span a range from 4.4 to almost 170 Gloss Units for light at 20° angle of incidence.
Research on bearing ZC feature selection method based on DWCMI
Authors: Chen Qing , Liu Tao , Wu Xing 
Published: January 2024

Abstract
In light of the issues related to the omission of crucial features and the incorrect selection of redundant features in existing feature selection methods for zero-crossing features, this paper presents a feature selection method based on dynamic weights condition mutual information (DWCMI). In this method, the main factor of the objective function for feature evaluation is conditional mutual information, while also incorporating a complementary evaluation criterion based on conditional mutual information to address the issue of misselecting redundant features. By introducing a dynamic weight coefficient, we can accurately measure the importance of selected features by assessing their dynamic change in mutual information, thereby avoiding any oversight of crucial features. In the process of designing the algorithm, computational efficiency is improved by buffering and reusing previously calculated mutual information. This approach avoids the issue of repeatedly calculating the mutual information. The necessity, effectiveness, and high efficiency of the DWCMI method have been verified through simulation and experimentation.
Accuracy assessment of crystal orientation indexations by EBSD
Authors: Shi Qiwei , Loisnard Dominique , Li Yang , Chen Zhe , Wang Haowei , Roux Stéphane 
Published: January 2024

Abstract
Accuracy and uncertainty analyses are essential for every measurement technology. In crystal orientation indexation by electron backscatter diffraction (EBSD), a series of accuracy estimations have been made for the Hough transform and dictionary indexation methods. The mean angular deviation is a standard parameter to indicate orientation accuracy, but this criterion is indirect and closely related to the accuracy of the projection center coordinates. Precise known orientation relationships (OR) are necessary to evaluate orientation accuracy without the ground truth. The current work uses the natural crystal twins and hardware OR to assess the orientation accuracy directly. The accuracy level for different EBSD analysis methods is compared through four experimental data sets of varying pattern definitions and noise levels. It is found that the full pattern match (FPM) algorithms improve the accuracy as compared to Hough indexation, and the gain varies greatly between 14% for fast acquisitions and 20 times for high-quality patterns. Depending on the resolution and quality of diffraction patterns, FPM results in an accuracy of crystal orientation between 0.04° and 0.9°. Comparing the two FPM variants, matching the gradients of diffraction patterns performs better in the case of high-to-median quality acquisitions while matching the pattern itself is more accurate for more noisy and low-definition patterns.