bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico SNP prediction of selected protein orthologues in insect models for Alzheimer's, Parkinson's, and Huntington’s diseases
Authors: Al-Ayari Eshraka A. , Shehata Magdi G. , EL-Hadidi Mohamed , Shaalan Mona G. 
Published: November 2023

AbstractAlzheimer's, Parkinson’s, and Huntington’s are the most common neurodegenerative diseases that are incurable and affect the elderly population. Discovery of effective treatments for these diseases is often difficult, expensive, and serendipitous. Previous comparative studies on different model organisms have revealed that most animals share similar cellular and molecular characteristics. The meta-SNP tool includes four different integrated tools (SIFT, PANTHER, SNAP, and PhD-SNP) was used to identify non synonymous single nucleotide polymorphism (nsSNPs). Prediction of nsSNPs was conducted on three representative proteins for Alzheimer's, Parkinson’s, and Huntington’s diseases; APPl in Drosophila melanogaster, LRRK1 in Aedes aegypti, and VCPl in Tribolium castaneum. With the possibility of using insect models to investigate neurodegenerative diseases. We conclude from the protein comparative analysis between different insect models and nsSNP analyses that D. melanogaster is the best model for Alzheimer’s representing five nsSNPs of the 21 suggested mutations in the APPl protein. Aedes aegypti is the best model for Parkinson’s representing three nsSNPs in the LRRK1 protein. Tribolium castaneum is the best model for Huntington’s disease representing 13 SNPs of 37 suggested mutations in the VCPl protein. This study aimed to improve human neural health by identifying the best insect to model Alzheimer's, Parkinson’s, and Huntington’s.
Efficacy and safety of polyethylene glycol loxenatide in type 2 diabetic patients: a systematic review and meta-analysis of randomized controlled trials
Authors: Salamah Hazem Mohamed , Marey Ahmed , Elsayed Esraa , Hasan Mohammed Tarek , Mahmoud Abdelrahman , Abualkhair Khaled Alsayed , Abo-elnour Dina Essam , Abdelhaleem Ibrahim Abdelmonaem , Abd-Elgawad Mohamed 
Published: November 2023

AbstractPolyethylene glycol loxenatide (PEX168) is a novel glucagon-like peptide-1 receptor agonist with a longer half-life developed by modifying the chemical structure of exenatide. This study aims to assess the efficacy and safety of PEX168 and determine the best dose. We searched PubMed, Scopus, Cochrane Library, and Web of Science databases from inception to April 25, 2023, for randomized controlled trials (RCTs) comparing PEX168 therapy alone or in combination with metformin versus other therapies. We used the risk ratio (RR) for dichotomous outcomes and the mean difference (MD) for continuous outcomes, both with 95% confidence intervals (CI). Six RCTs, including 1248 participants, were included. PEX168 added to metformin was significantly better than metformin alone regarding fasting blood glucose (MD = −1.20, 95% CI (−1.78,  − 0.62), p < 0.0001), HbA1c (MD = −1.01, 95% CI (−1.48,  − 0.53), p < 0.0001), and postprandial glycemia (MD = −1.94, 95% CI (−2.99,  − 0.90), p = 0.0003). Similarly, for glycemic control, PEX168 monotherapy was superior to placebo (P < 0.05). No significant effects were noticed in terms of triglycerides, low-density lipoprotein, or high-density lipoprotein (p > 0.05). Body weight was significantly reduced in obese diabetic patients receiving PEX168 compared to the control group (MD = −5.46, 95% CI (−7.90,  − 3.01), p < 0.0001) but not in non-obese patients (MD = 0.06, 95% CI (−0.47, 0.59), p = 0.83). People who received PEX168 alone or with metformin showed more common gastrointestinal adverse effects, especially nausea and vomiting (p < 0.05). PEX168 100, 200, and 300 ug monotherapy demonstrated comparable safety and diabetes control to metformin, but when combined with metformin, PEX168 100 and 200 ug showed significant effects on diabetes control; however, only the latter showed a significantly higher incidence of nausea and vomiting (p < 0.05). PEX168 could be a viable option for treating diabetic patients whose metformin control is inadequate or who cannot tolerate metformin. PEX168 at 100 ug in combination with metformin was found to be safe and more effective compared to metformin; however, due to the small number of trials included, these findings should be interpreted with caution, and additional trials are required.
A duplex droplet digital PCR assay for absolute quantification and characterization of long self-amplifying RNA
Authors: Casmil Irafasha C. , Huang Cynthia , Blakney Anna K. 
Published: November 2023

AbstractSelf-amplifying messenger ribonucleic acid (saRNA) provides extended expression of genes of interest by encoding an alphavirus-derived RNA replicase and thus is 2–3 times larger than conventional messenger RNA. However, quality assessment of long RNA transcripts is challenging using standard techniques. Here, we utilized a multiplex droplet digital polymerase chain reaction (ddPCR) assay to assess the quality of saRNA produced from an in vitro transcription reaction and the replication kinetics in human cell lines. Using the one-step reverse transcription ddPCR, we show that an in vitro transcription generates 50–60% full-length saRNA transcripts. However, we note that the two-step reverse transcription ddPCR assay results in a 20% decrease from results obtained using the one-step and confirmed using capillary gel electrophoresis. Additionally, we provided three formulas that differ in the level of stringency and assumptions made to calculate the fraction of intact saRNA. Using ddPCR, we also showed that subgenomic transcripts of saRNA were 19-to-108-fold higher than genomic transcripts at different hours post-transfection of mammalian cells in copies. Therefore, we demonstrate that multiplex ddPCR is well suited for quality assessment of long RNA and replication kinetics of saRNA based on absolute quantification.
Estimating optimum and base selection indices in plant and animal breeding programs by development new and simple SAS and R codes
Authors: Rahimi Mehdi , Debnath Sandip 
Published: November 2023

AbstractSelection of desirable genotypes or progenies is perhaps the most important practical method in plant and animal breeding programs. The selection index method is the most useful method to choose superior genotypes based on using simultaneous several traits. The optimum and base selection indices are the two indicators that are most used in plant and animal breeding. In this paper, a simple and practical code was developed for the analysis of optimum, base, and Pesek and Baker selection indices. Four different criteria were used to evaluate the selection index, and the phenotypic and genotypic variance–covariance matrix of traits was obtained based on statistical or genetical design. Moreover, an index that was more efficient on these coefficients was used for the breeding program. The results showed that simultaneous selection for the important traits desired by the breeder through economic values such as heritability, genetic, or phenotypic correlation is the most effective method for selecting the best genotypes. Therefore, the best progeny or genotype can be selected to use in breeding programs. This program provides detailed information on selection indices of segregation and natural populations involving any number of individuals or genotypes. These codes are much easier and simpler than other programs and provide more information than other programs. This code is easy to execute in both R and SAS programs.
The inverse association between DNA gaps and HbA1c levels in type 2 diabetes mellitus
Authors: Thongsroy Jirapan , Mutirangura Apiwat 
Published: November 2023

AbstractNaturally occurring DNA gaps have been observed in eukaryotic DNA, including DNA in nondividing cells. These DNA gaps are found less frequently in chronologically aging yeast, chemically induced senescence cells, naturally aged rats, d-galactose-induced aging model rats, and older people. These gaps function to protect DNA from damage, so we named them youth-associated genomic stabilization DNA gaps (youth-DNA-gaps). Type 2 diabetes mellitus (type 2 DM) is characterized by an early aging phenotype. Here, we explored the correlation between youth-DNA-gaps and the severity of type 2 DM. Here, we investigated youth-DNA-gaps in white blood cells from normal controls, pre-DM, and type 2 DM patients. We found significantly decreased youth-DNA-gap numbers in the type 2 DM patients compared to normal controls (P = 0.0377, P = 0.0018 adjusted age). In the type 2 DM group, youth-DNA-gaps correlate directly with HbA1c levels. (r = − 0.3027, P = 0.0023). Decreased youth-DNA-gap numbers were observed in patients with type 2 DM and associated with increased HbA1c levels. Therefore, the decrease in youth-DNA-gaps is associated with the molecular pathogenesis of high blood glucose levels. Furthermore, youth-DNA-gap number is another marker that could be used to determine the severity of type 2 DM.
The geological factors affecting gas content and permeability of coal seam and reservoir characteristics in Wenjiaba block, Guizhou province
Authors: Feng Cong , Li Xijian , Yang Rui , Cai Junjie , Sui Hao , Xie Honggao , Wang Ziyi 
Published: November 2023

AbstractThe gas content and permeability of coal reservoirs are the main factors affecting the productivity of coalbed methane. To explore the law of gas content and permeability of coal reservoirs in the Zhijin area of Guizhou, taking No.16, No.27 and No.30 coal seams in Wenjiaba mining area of Guizhou as the engineering background, based on the relevant data of coalbed methane exploration in Wenjiaba block, the geological structure, coal seam thickness, coal quality characteristics,coal seam gas content and permeability of the area were studied utilizing geological exploration, analysis of coal components and methane adsorption test. The results show that the average thickness of coal seams in this area is between 1.32 and 1.85 m; the average buried depth of the coal seam is in the range of 301.3–384.2 m; the gas content of No.16 and No.27 coal seams is higher in the syncline core. The gas content of the No.30 coal seam forms a gas-rich center in the south of the mining area. The buried depth and gas content of coal seams in the study area show a strong positive correlation. Under the same pressure conditions, the adsorption capacity of dry ash-free basis is significantly higher than that of air-dried coal. The permeability decreases exponentially with the horizontal maximum principal stress and the horizontal minimum principal stress. The horizontal maximum primary stress and the flat minimum prominent stress increase with the increase of the buried depth of the coal seam. The permeability and coal seam burial depth decrease exponentially. This work can provide engineering reference and theoretical support for selecting high-yield target areas for CBM enrichment in the block.
Facile preparation, characterization, and investigation of mechanical strength of Starchy NaCl-binder as a lightweight construction material
Authors: Fahmi Ahmad , Zavaragh Sohrab Rafati , Hanafi Mohammad Reza , Rahimpour Hamed , Zinatloo-Ajabshir Sahar , Asghari Ali 
Published: November 2023

AbstractSodium chloride (NaCl), commonly known as salt, is a substance that is utilized in a variety of businesses, including the tourism and construction industries. Therefore, the main purpose of this article is to accommodate a salt-based building material called NaCl-binder for tourist and industrial applications. By utilizing salt mortar with varying grain sizes, food-grade corn starch as an exclusive binder agent (without using any non-starch binder), and water under microwave-cured conditions, environmentally friendly hydrophobic hybrid NaCl-binder samples with low bulk density were successfully produced. The fabrication of these samples involved an inventive utilization of small quantities of starch. This study evaluated the impact of microwave exposure time on the strength of salt samples, particle interconnectivity and chemical composition using SEM, XRD, and XRF analyses. The compressive strength of the samples showed a remarkable increase, with a 600% improvement when using 0 to 1% corn starch, and a 137% increment when using 1 to 10% corn starch, indicating a lower rate of increment with higher starch consumption. A key aspect of this research is the significant reduction in starch consumption compared to other corn starch-based materials during the manufacturing process of the incorporated materials, highlighting its novelty and importance.
A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation
Authors: Palermo Amelia , Li Shen , ten Hoeve Johanna , Chellappa Akshay , Morris Alexandra , Dillon Barbara , Ma Feiyang , Wang Yijie , Cao Edward , Shabane Byourak , Acín-Perez Rebeca , Petcherski Anton , Lusis A. Jake , Hazen Stanley , Shirihai Orian S. , Pellegrini Matteo , Arumugaswami Vaithilingaraja , Graeber Thomas G. , Deb Arjun 
Published: November 2023

AbstractThe ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate the effects of a KD on systemic toxicity in mice following SARS-CoV-2 infection. Our data indicate that under KD, SARS-CoV-2 reduces weight loss with overall improved animal survival. Muted multi-organ transcriptional reprogramming and metabolism rewiring suggest that a KD initiates and mitigates systemic changes induced by the virus. We observed reduced metalloproteases and increased inflammatory homeostatic protein transcription in the heart, with decreased serum pro-inflammatory cytokines (i.e., TNF-α, IL-15, IL-22, G-CSF, M-CSF, MCP-1), metabolic markers of inflammation (i.e., kynurenine/tryptophane ratio), and inflammatory prostaglandins, indicative of reduced systemic inflammation in animals infected under a KD. Taken together, these data suggest that a KD can alter the transcriptional and metabolic response in animals following SARS-CoV-2 infection with improved mice health, reduced inflammation, and restored amino acid, nucleotide, lipid, and energy currency metabolism.
Morphology controlled performance of ternary layered oxide cathodes
Authors: Meng Zifei , Ma Xiaotu , Azhari Luqman , Hou Jiahui , Wang Yan 
Published: November 2023

AbstractWith the rapid advancement of electric vehicle technologies, ternary layered oxide cathodes in commercial Li-ion batteries have become increasingly promising due to their high energy density and low cost. However, the need for higher energy density and cell stability has posed significant challenges in their development. While various coating and doping strategies have been demonstrated to improve the rate and cycle performance of cathode materials, morphology-focused modifications of these cathodes are sometimes overlooked, despite their impact on electrochemical performance. Herein, this review focuses on the morphological relationship of cathode materials to their electrochemical performance. We summarize the effects of cathode materials morphology on Li-ion diffusion and stability. We also discuss the recent advances in the development of cathode materials with different morphologies. Finally, we present future perspectives for the design of cathode materials with optimized morphologies to promote their commercialization and fundamental research.
Optimizing performance of a reduced switch multi‐level inverter with moth‐flame algorithm and SHE‐PWM
Authors: Shanono Ibrahim Haruna , Abdullah Nor Rul Hasma , Daniyal Hamdan , Muhammad Aisha 
Published: November 2023

AbstractMulti‐level inverters are widely used in high‐voltage and high‐power applications due to the increasing demand for renewable energy. This study proposes a novel single‐phase reduced switch multi‐level inverter topology that generates 11 levels of output voltage steps, operates in asymmetric mode, and uses fewer power electronic switches with efficient switching control. To optimize the inverter's performance, Moth Flame Optimization (MFO), Particle Swarm Optimization (PSO), and Whale Optimization Technique (WOA) are utilized to apply the selective harmonic elimination technique. The proposed circuit is implemented in PSIM software using optimized switching angles, and the fitness functions and switching angles for the three optimizers are evaluated and reported. The inverter's performance at optimal modulation points for the three optimizers is computed and analyzed, with the Total Harmonic Distortion (THD) measured at 0.82 modulation point before and after filtering. Results show that MFO outperforms PSO and WOA with the lowest THD values of 0.85% and 0.78%, respectively; therefore, complying with the IEEE 519 standard. The experimental validation of MFO's superiority is performed using the Typhoon HIL‐402 hardware device. This study provides a promising solution for the design and optimization of multi‐level inverters, paving the way for more efficient and reliable renewable energy systems.
A3COSMOS: The infrared luminosity function and dust-obscured star formation rate density at 0.5 < z < 6
Authors: Traina A. , Gruppioni C. , Delvecchio I. , Calura F. , Bisigello L. , Feltre A. , Magnelli B. , Schinnerer E. , Liu D. , Adscheid S. , Behiri M. , Gentile F. , Pozzi F. , Talia M. , Zamorani G. , Algera H. , Gillman S. , Lambrides E. , Symeonidis M. 
Published: November 2023

Aims. We leverage the largest available Atacama Large Millimeter/submillimeter Array (ALMA) survey from the archive (A3COSMOS) to study infrared luminosity function and dust-obscured star formation rate density of (sub)millimeter galaxies from z = 0.5 − 6.
Methods. The A3COSMOS survey utilizes all publicly available ALMA data in the COSMOS field and therefore has inhomogeneous coverage in terms of observing wavelength and depth. In order to derive the luminosity functions and star formation rate densities, we applied a newly developed method that corrects the statistics of an inhomogeneously sampled survey of individual pointings to those representing an unbiased blind survey.
Results. We find our sample to mostly consist of massive (M⋆ ∼ 1010 − 1012 M⊙) IR-bright (L* ∼ 1011 − 1013.5 L⊙) highly star-forming (SFR ∼100 − 1000 M⊙
yr−1) galaxies. We find an evolutionary trend in the typical density (Φ*) and luminosity (L*) of the galaxy population that respectively decreases and increases with redshift. Our infrared luminosity function (LF) is in agreement with previous literature results, and we were able to extend the constraints on the knee and bright end of the LF to high redshift (z > 3) by using the Herschel data. Finally, we obtained the star formation rate density up to z ∼ 6 by integrating the IR LF, finding a broad peak from z ∼ 1 to z ∼ 3 and a decline toward higher redshifts, in agreement with recent IR/millimeter-based studies, within the uncertainties. These results imply the presence of larger quantities of dust than what is expected based on optical/UV studies.
2-power domination number for Knödel graphs and its application in communication networks
Authors: Sundara Rajan R. , Arulanand S. , Prabhu S. , Rajasingh Indra 
Published: November 2023

In a graph G, if each node v ∈ V(G) \ S is connected to some node in S, then the set S of nodes is referred to as a dominating set. The domination number of G is the minimum cardinality of all dominating sets of G and is represented by γ(G). If a dominating set S monitors every node in the system under a set of guidelines for power systems monitoring, then the set S is referred to as a power-dominating set of G. The power domination number of G is the least number of vertices of a power dominating set of G. A generalization of power domination is the k-power domination in a graph G. The k-power domination number of G is the minimum cardinality of all k-power dominating sets of G and is represented by γp,k(G). In this paper, we have obtained the 2-power domination number represented by γp,2(G) for 4-regular Knödel graphs and given the lower bound for 5-regular Knödel graphs.
The contact-based emergence of the subject-focus construction in Wolof
Authors: Bourdeau Corentin , Rojas-Berscia Luis Miguel 
Published: November 2023

Abstract
In this article, we focus on the origin of the Wolof subject-focus construction (SFC) from a dynamic perspective.
In Wolof, argument focus is expressed morpho-syntactically by means of copulaless cleft constructions consisting of the
juxtaposition of the focus and a free relative clause. The free relative clause is headed by a determiner, which takes the form
a in the case of the SFC. The determiner a is not found anywhere else in the language
outside of SFC. We hypothesise that Wolof borrowed its SFC from Berber languages. The sociohistorical scenario, based on oral
tradition, could have been the emergence of Wolof, as a crucible of contact between peoples of diverse origin including Berber
groups. This finding is strengthened by the occurrence of other elements common to Wolof and Berber languages, such as clitic
attraction, negation, copula insertion, as well as a number of lexical parallelisms.
Univerbation in Afrikaans verbal diminutives
Authors: Cavirani-Pots Cora , Villiers Engela De 
Published: November 2023

Abstract
This paper concerns the verbal diminutive suffixes -el and -er in Afrikaans. In previous work (Cavirani-Pots et al. 2023), these suffixes have been analysed on par with their Dutch counterparts. In this paper we present the results of a nonsense word experiment on these suffixes in Afrikaans (94 participants) and Dutch (242 participants). The results show that the Afrikaans participants significantly underperform in guessing the meaning of these suffixes compared to the Dutch participants. We take this to mean that the underlying structure of verbs containing these suffixes is different in the two languages. Based on the three-way division of affix types of Creemers et al. (2018), we follow Cavirani-Pots et al. (2023)’s analysis of the Dutch -el and -er suffixes as being level Ia suffixes, i.e. suffixes that appear right above the stem they attach to. For Afrikaans, however, we propose that -el and -er have lost their suffixal status, and have undergone univerbation with the stem.
Everything is not equal in adult and child Dutch
Authors: van Kampen Jacqueline 
Published: November 2023

Abstract
An investigation into the production of universal quantifiers with negation in the CHILDES database of Dutch shows several scopal properties that have not been discussed before. First, it shows a crucial distinction between child and adult Dutch. A universal quantifier with scope over negation has an isomorphic interpretation in adult Dutch, but an inverse scope interpretation in child Dutch. This raises the question why children do not adopt the surface scope interpretation. Second, it indicates a possible answer to the puzzle why languages often avoid a universal quantifier under the scope of negation. I will discuss the idea that the explanation may lie in the type of reading of a quantifier, collective/distributive and specific/non-specific. It might also explain why no language has a lexicalized negated universal pronoun *neverything.
Dit is Laura-se (trui)
Authors: van Kampen Jacqueline 
Published: November 2023

Abstract
Dutch children temporarily use a possessor se construction with proper/kinship names and pronouns, like dit is Laura-se/opa-se/hem-se jas (‘this is Laura’s/grandpa’s/his coat’). The se possessive is not available in standard Dutch, although examples of it are found on the internet. The se possessive is fully productive with all nouns in Afrikaans.
In standard Dutch prenominal possessive constructions show a wide range of variations and restrictions. Dutch children avoid the complexity of the system, but what makes the children apply the se possessive in the first place? I will show that it is due to three properties specific to Dutch. Nevertheless, the se possessive does not persist in standard Dutch as it did in Afrikaans. The Dutch Achilles’ heel might be the early use of weak possessive pronouns.