bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization and validation of a suprasystolic brachial cuff‐based method for noninvasively estimating central aortic blood pressure
Authors: Zhang Xujie , Wang Yue , Yin Zhaofang , Liang Fuyou 
Published: January 2024

AbstractClinical studies have extensively demonstrated that central aortic blood pressure (CABP) has greater clinical significance in comparison with peripheral blood pressure. Despite the existence of various techniques for noninvasively measuring CABP, the clinical applications of most techniques are hampered by the unsatisfactory accuracy or large variability in measurement errors. In this study, we proposed a new method for noninvasively estimating CABP with improved accuracy and reduced uncertain errors. The main idea was to optimize the estimation of the pulse wave transit time from the aorta to the occluded lumen of the brachial artery under a suprasystolic cuff by identifying and utilizing the characteristic information of the cuff oscillation wave, thereby improving the accuracy and stability of the CABP estimation algorithms under various physiological conditions. The method was firstly developed and verified based on large‐scale virtual subject data (n = 800) generated by a computational model of the cardiovascular system coupled to a brachial cuff, and then validated with small‐scale in vivo data (n = 34). The estimation errors for the aortic systolic pressure were −0.05 ± 0.63 mmHg in the test group of the virtual subjects and −1.09 ± 3.70 mmHg in the test group of the patients, both demonstrating a good performance. In particular, the estimation errors were found to be insensitive to variations in hemodynamic conditions and cardiovascular properties, manifesting the high robustness of the method. The method may have promising clinical applicability, although further validation studies with larger‐scale clinical data remain necessary.
Detection of phishing addresses and pages with a data set balancing approach by generative adversarial network (GAN) and convolutional neural network (CNN) optimized with swarm intelligence
Authors: Jafari Somayyeh , Aghaee‐Maybodi Nasrin 
Published: January 2024

SummaryPhishing attacks have a remarkable ability to steal user information by using simple techniques. Phishing attacks steal valuable information, such as user names and passwords. The loss caused by phishing attacks is significant, and every year, millions of dollars are lost by internet users and companies through phishing attacks. Deep learning methods such as CNN neural network are one approach to detecting phishing attacks: deep learning methods, optimization for image processing, and efficient techniques used to process URL strings. A convolutional neural network is a widely used deep learning method in image processing. The limitation of CNN learning to images is one of the main challenges of this neural network for detecting phishing attacks. Imbalance in the training dataset and lack of intelligent feature selection are other challenges for CNN training in detecting phishing attacks. This manuscript presents a new approach called CGAN‐IWSO‐ResNet50 to detect phishing attacks. In the first step, the improved version of the conditional GAN is used to balance the URL samples. In the second stage, Hand‐crafted and TF‐IDF methods implement the feature extraction phase. In the feature selection stage, the WOA algorithm is used to improve the WSO algorithm's performance in feature selection. The selected features are implemented on the dataset, and legal and phishing samples are coded as RGB images. In the last step, RGB images are used to teach ResNet50 architecture. Tests in the PhishTank dataset showed that the proposed method's accuracy, sensitivity, and precision index are 99.65%, 99.12%, and 99.46%, respectively. The CGAN‐IWSO‐ResNet50 method is more accurate in detecting phishing attacks than the VGG19, AlexNet, RCNN, DNN + LSTM, and DNN + BiLSTM learning methods.
Rotational Spectroscopy and Conformational Flexibility of 2‐Phenylethanethiol: The Dominant S−H⋅⋅⋅π Intramolecular Hydrogen Bond
Authors: Tama Saragi Rizalina , Li Wenqin , Juanes Marcos , Enríquez Lourdes , Pinacho Ruth , Rubio José Emiliano , Lesarri Alberto 
Published: January 2024

AbstractWe present a rotational‐computational investigation of the aromatic mercaptan 2‐phenylethanethiol, addressing its potential energy surface, conformational equilibrium, internal dynamics and intramolecular interactions. The experiment used broadband chirped‐pulse Fourier transform microwave spectroscopy in a supersonic jet expansion, recording the rotational spectrum in the 2–8 GHz frequency region. Two different conformers were detected in the spectrum. The most intense transitions correspond to a skew (gauche‐gauche) conformation, identified as the global minimum. The spectra of ten different isotopologues were assigned for this species, leading to accurate effective and substitution structures. The weaker spectrum presents small tunnelling doublings caused by the torsional motion of the thiol group, which are only compatible with an antiperiplanar skeleton and a gauche thiol. The larger stability of the global minimum is attributed to an intramolecular S−H⋅⋅⋅π weak hydrogen bond. A comparison of the intramolecular interactions in the title molecule and 2‐phenylethanol, similarly stabilized by a O−H⋅⋅⋅π hydrogen bond, shows the different strength of these interactions. Density functional (B3LYP‐D3, B2PLYP‐D3) and ab initio (MP2) calculations were conducted for the molecule.
Recovering Misidentified Samples Through Genetic Discordance Clustering
Authors: Huang Jesse , Kockum Ingrid , Stridh Pernilla 
Published: January 2024

AbstractThe many logistical and technical challenges associated with sample and data handling in largescale genotyping studies can increase the risk of sample misidentification, which may compromise subsequent analyses. However, the standard quality assurance methods typical for large genotyping arrays can often be further utilized to identify and recover problematic samples. This article emphasizes the importance of identifying and correcting underlying sample misidentification rather than simply excluding known discrepancies, which may potentially include undetected issues. Lastly, we provide a screening protocol to complement standard quality assessments as a guideline for identifying mismatched samples and a tool for assessing the most common causes of sample misidentification. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC.
Configurations of corporate governance mechanisms and sustainable development
Authors: Torres Pedro 
Published: January 2024

AbstractAiming to shed light on the interplay of board‐related mechanisms and their influence on sustainable development, this study examines configurations of corporate governance conditions that are associated with high and low ESG performance. Fuzzy‐set qualitative comparative analysis was used, resorting to a sample of S&P 500 manufacturing companies that are committed to contributing to solve the climate change societal challenge (i.e., SDG13). The configurational analysis was also extended to the all sample of S&P 500 companies to assure the generalizability of the findings and provide additional insights. The findings support the functional view of the role of the board, emphasising the notion that configurations (i.e., combinations of conditions) are more important to sustainable development than any single condition. Different from past research, this study emphasises the importance of defining and implementing a CSR strategy to achieve high ESG performance, which is always present in configurations leading to the outcome of interest. Furthermore, the results also suggest that a monitoring mechanism should always be present, while an incentive alignment mechanism is only required in some circumstances. Moreover, the results show that ESG‐related executive compensation should be complemented with other mechanisms, such as board monitoring, to be effective. This study contributes to the debate on whether sustainability‐related performance alignment incentives and monitoring mechanisms act as complements or substitutes. The findings show that linear approaches might not capture the all picture, suggesting that a more nuanced view should be used in future studies, and can inform companies' strategic decisions regarding sustainability.
A new harmonic detection strategy based on improved series repetitive controller
Authors: Liu Pu , Wang Cong , Lu Kaiping , Zu Lifeng , Cui Yibo , Liang Yan , Chang Zhongting 
Published: January 2024

SummaryThe d‐q detection method based on instantaneous reactive power theory (IRPT) is one of the commonly used time‐domain analysis methods for harmonic detection. Due to the poor dynamic performance of the algorithm caused by the low pass filter (LPF) in the d‐q detection method, an improved series repetitive control (ISRC) structure is proposed in this paper. Using attenuation factor and correction factor to improve the series repetitive controller, the ISRC contains a negative resonance peak with a peak value of 150 dB at the 6 k harmonic frequency, and the amplitude gain is 0 dB at frequencies outside the 6 k harmonic frequency. Therefore, ISRC can achieve good attenuation effect on 6 k harmonics while maintaining the same gain at other frequencies. ISRC is used instead of LPF in the traditional d‐q detection and this strategy improves the dynamic response of the system while guaranteeing its steady state performance. Finally, simulations and experiments verify the feasibility of the strategy.
Early development of object manipulation in capuchin monkeys: A naturalistic approach
Authors: Araujo Guilbert , Truppa Valentina , Izar Patrícia 
Published: January 2024

AbstractHow human and non‐human primates develop their object manipulation skills has been considered an important aspect for understanding the evolution of motor and cognitive abilities in the primate order. Here, we aimed to describe the development of object manipulation from birth to 6 months in robust capuchin monkeys, platyrrhine primates well known for their highly manipulative skills, which partly resemble those observed in catarrhines. To our knowledge, this is the first longitudinal study to investigate the developmental trajectory of object manipulation in capuchin monkeys with a naturalistic approach. For this purpose, eight infants from a wild population of bearded capuchin monkeys were studied in the North‐East of Brazil. Data were coded from focal‐day recordings of these infants. Our results highlighted the speed and trajectory of change in the development of manipulative action over the first 6 months. In the early stages of development, infants use gentle skills to hold and touch objects. Later, with the acquisition of dexterity and postural control, they begin to exhibit behaviors requiring more complex motor patterns and/or combinatorial actions, such as rubbing and hitting objects. Additionally, we found that the target of manipulation shifted over time, with food interactions gaining prominence. Part of our data parallels those from captive‐born individuals, whereas some findings suggest that certain manipulative skills might emerge later in wild capuchins.
Comparative analysis of electrodermal activity metrics and their association with child behavior in autism spectrum disorder
Authors: Greenlee Jessica L. , Lorang Emily , Olson Robert H. , Rodriquez Geovanna , Yoon Dasoo Milton , Hartley Sigan 
Published: January 2024

AbstractResearchers are increasingly utilizing physiological data like electrodermal activity (EDA) to understand how stress “gets under the skin.” Results of EDA studies in autistic children are mixed, with some suggesting autistic hyperarousal, others finding hypoarousal, and yet others detecting no difference compared to non‐autistics. Some of this variability likely stems from the different techniques used to assess EDA. Therefore, the purpose of this study is to investigate and compare commonly used metrics of EDA (frequency of peaks, average amplitude of peaks, and standard deviation of skin conductance level) using two data processing programs (NeuroKit2 and Ledalab) and their link to observed child behavior. EDA data were collected using Empatica E4 wristbands from 60 autistic children and adolescents (5–18 years old) during a 7‐min play interaction with their primary caregiver. The play interaction was coded for a range of child behaviors including mood, social responsiveness, dysregulation, and cooperation. Results indicate a strong correlation between NeuroKit2 and Ledalab and a weak correlation between metrics within each program. Furthermore, the frequency of peaks was associated with more positive child social behaviors, and the magnitude of peaks was associated with less adaptive child behaviors. Recommendations for replication and the need for generalizability of this research are given.
Retreating coastal forest supports saltmarsh invertebrates
Authors: Goetz Emily M. , Johnson David S. 
Published: January 2024

AbstractAs sea‐level rise converts coastal forest to salt marsh, marsh arthropods may migrate inland; however, the resulting changes in arthropod communities, including the stage of forest retreat that first supports saltmarsh species, remain unknown. Furthermore, the ghost forest that forms in the wake of rapid forest retreat offers an unknown quality of habitat to marsh arthropods. In a migrating marsh in Virginia, USA, ground‐dwelling arthropod communities were assessed across the forest‐to‐marsh gradient, and functional use of ghost forest and high marsh habitats was evaluated to determine whether marsh arthropods utilized expanded marsh in the same way as existing marsh. Diet and body condition were compared for two marsh species found in both high marsh and ghost forest (the detritivore amphipod, Orchestia grillus, and the hunting spider, Pardosa littoralis). Community composition differed among zones along the gradient, driven largely by retreating forest taxa (e.g., Collembola), marsh taxa migrating into the forest (e.g., O. grillus), and unique taxa (e.g., Hydrophilinae beetles) at the ecotone. The low forest was the most inland zone to accommodate the saltmarsh species O. grillus, suggesting that inland migration of certain saltmarsh arthropods may co‐occur with early saltmarsh plant migration and precede complete tree canopy die‐off. Functionally, O. grillus occupied a larger trophic niche in the ghost forest than the high marsh, likely by consuming both marsh and terrestrial material. Despite this, both observed marsh species primarily consumed from the marsh grass food web in both habitats, and no lasting differences in body condition were observed. For the species and functional traits assessed, the ghost forest and high marsh did not show major differences at this site. Forest retreat and marsh migration may thus provide an important opportunity for generalist saltmarsh arthropods to maintain their habitat extent in the face of marsh loss due to sea‐level rise.
Physicochemical properties of barley starch and effect of substitution of wheat flour with barley starch on texture and sensory properties of bread
Authors: Devi Rekhashree , Singh Awanish , Dutta Ditimoni , Sit Nandan 
Published: January 2024

AbstractIn the present study, starch was isolated from barley and the physicochemical and functional properties of the starch were examined. Then the starch was used to prepare bread by substituting wheat flour at three different levels, namely 5%, 10%, and 15%. The rheological properties of the dough and the texture and sensory properties of the prepared breads were investigated. The moisture, protein, starch, fat and ash content of the barley starch (BS) were 10.39 ± 0.03%, 0.08 ± 0.02%, 94.30 ± 0.02%, 0.12 ± 0.03%, and 0.09 ± 0.04%, respectively, whereas the amylose content of the BS was 18.68 ± 0.01%. The rheological study showed the pseudoplastic nature of BS. The elastic moduli values were higher than viscous moduli values for the control dough, and dough prepared by substituting 5% and 10% BS. But in the case of 15% substitution, the elastic moduli values were lower than viscous moduli values. The texture and sensory evaluation studies also showed that bread prepared by substituting wheat flour with BS has better texture and consumer acceptability than the control sample. It can be concluded that wheat flour can be substituted with BS by up to 10% to improve the texture of the bread.
Recent Advances in the Preparation of Air Stable Organozinc Pivalates and their Applications in Organic Synthesis
Authors: Dhayalan Vasudevan , Dodke Vishal S. , Sharma Deepika , Dandela Rambabu 
Published: January 2024

AbstractThis review discusses various methods for the preparation of air and water‐stable organozinc pivalates containing aryl, heteroaryl, alkyl, alkenyl, benzyl and alkynyl scaffolds achieved via i) selective metalation (DoM) in the presence of a directing group (DG) in the aromatic core, ii) direct oxidative Zn metal insertion/or X/M exchange reaction followed by transmetalation with Zn(Opiv)2, which are then further functionalized by Negishi cross‐coupling reactions, or trapping with different aryl, heteroaryl, alkenyl, alkynyl electrophiles used by transition metal catalysts (Pd, Co, Ni, Cu). Selective deprotonation of aryl or heteroaryl derivatives can be performed using LDA, TMP−Mg and TMP−Zn reagents in the presence of a directing group on the aromatic system. Different organozinc reagents based on aromatic and non‐aromatic structures with electron‐rich and electron‐deficient substituents undergo transition metal‐catalyzed C(sp2)−C(sp2), C(sp2)−C(sp) and C(sp2)−C(sp3) types of cross‐coupling reactions with aryl and heteroaryl halides and diaryl disulfides under mild conditions with the sustainable catalytic process. The literature report shows that the polyfunctionalized nitrogen, oxygen and sulfur‐based bioactive pharmaceutical scaffolds, natural products and target organic molecules are accessible using highly air and moisture‐stable organozinc pivalates under sustainable coupling reaction conditions. Importantly, the sensitive functional groups are tolerable, and the commercially available substrates and inexpensive low toxic reagents can be employed with organozinc pivalates. In this context, this review article provides a detailed summary of the numerous synthetic strategies and practical methods for the preparation of aryl, alkenyl, benzyl and alkynyl organozinc reagents that can be isolated in the pure solid form. Additionally, some recently published examples demonstrating their catalytic application in organic synthesis are discussed.
Formylation of Propargylic Alcohols with Difluorocarbene
Authors: Mou Dan , Wang Linda , Du Zhengyin 
Published: January 2024

AbstractA method for the synthesis of propargylic formates from propargylic alcohols and sodium chlorodifluoroacetate is reported. In the reaction, sodium chlorodifluoroacetate is used as a difluorocarbene precursor and a formylating reagent to provide a carbonyl source, while the triple bond of propargylic alcohols is not involved. The method shows convenient operation, good functional group tolerance and high site‐selectivity under mild reaction conditions.
A case of postoperative non‐invasive mucosal implantation of early‐stage cervical adenocarcinoma to the clitoris
Authors: Wang Rongmin , Ma Lingwei , Xiao Yinping , Jiang Hongyuan , Zhu Jin , Xia Hexia 
Published: January 2024

SynopsisPostoperative non‐invasive mucosal implantation of cervical adenocarcinoma on the clitoris is rare. Surgical resection is appropriate for local recurrence in the vulva.
Cross‐reaction mediated by distinct key amino acid combinations in the complementary‐determining region (CDR) of a monoclonal antibody
Authors: Guo Chunyan , Feng Qing , Xie Xin , Li Yan , Hu Hanyu , Hu Jun , Fang Senbiao , Shang Lijun 
Published: January 2024

AbstractIn immunology, cross‐reaction between antigens and antibodies are commonly observed. Prior research has shown that various monoclonal antibodies (mAbs) can recognize a broad spectrum of epitopes related to influenza viruses. However, existing theories on cross‐reactions fall short in explaining the phenomena observed. This study explored the interaction characteristics of H1‐74 mAb with three peptides: two natural peptides, LVLWGIHHP and LPFQNI, derived from the hemagglutinin (HA) antigen of the H1N1 influenza virus, and one synthetic peptide, WPFQNY. Our findings indicate that the complementarity‐determining region (CDR) of H1‐74 mAb comprised five antigen‐binding sites, containing eight key amino acid residues from the light chain variable region and 16 from the heavy chain variable region. These critical residues formed distinct hydrophobic or hydrophilic clusters and functional groups within the binding sites, facilitating interaction with antigen epitopes through hydrogen bonding, salt bridge formation, and π–π stacking. The study revealed that the formation of the antibody molecule led to the creation of binding groups and small units in the CDR, allowing the antibody to attach to a variety of antigen epitopes through diverse combinations of these small units and functional groups. This unique ability of the antibody to bind with antigen epitopes provides a new molecular basis for explaining the phenomenon of antibody cross‐reaction.
Outcomes of children with constipation and autism spectrum disorder treated with antegrade continence enemas
Authors: Srinivas Shruthi , Halaweish Ihab , Knaus Maria E. , Ahmad Hira , Griffin Kristine L. , Stephenson Kevin G. , Yossef Lina , Trimble Casey , Jimenez Alberta L. Negri , Lu Anan , Gasior Alessandra , Wood Richard J. , Williams Kent C. 
Published: January 2024

AbstractBackgroundTreatment of functional constipation (FC) in children with autism spectrum disorder (ASD) is challenging due to sensory and behavioral issues. We aimed to understand whether antegrade continence enemas (ACEs) are successful in the treatment of FC in children with ASD.MethodsA single‐institution retrospective review was performed in children diagnosed with ASD and FC who underwent appendicostomy or cecostomy placement from 2007 to 2019. Descriptive statistics regarding soiling and complications were calculated.ResultsThere were 33 patients included, with a median age of 9.7 years at the time of ACE initiation. The average intelligence quotient was 63.6 (SD = 18.0, n = 12), the average behavioral adaptive score was 59.9 (SD = 11.1, n = 13), and the average total Child Behavioral Checklist score was 72.5 (SD = 7.1, n = 10). Soiling rates were significantly lower following ACE initiation (42.3% vs. 14.8%, p = 0.04). Behavioral issues only prevented 1 patient (3.0%) from proper ACE use. Eleven patients (36.6%) were able to transition to laxatives. There were significant improvements in patient‐reported outcomes measures and quality of life.ConclusionPlacement of an appendicostomy or cecostomy for management of FC in children with severe ASD was successful in treating constipation and improving quality of life.