bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical radioguidance with beta-emitting radionuclides; challenges and possibilities: A position paper by the EANM
Authors: Fragoso Costa Pedro , Shi Kuangyu , Holm Soren , Vidal-Sicart Sergi , Kracmerova Tereza , Tosi Giovanni , Grimm Jan , Visvikis Dimitris , Knapp Wolfram H. , Gnanasegaran Gopinath , van Leeuwen Fijs W. B. 
Published: January 2024

AbstractRadioguidance that makes use of β-emitting radionuclides is gaining in popularity and could have potential to strengthen the range of existing radioguidance techniques. While there is a strong tendency to develop new PET radiotracers, due to favorable imaging characteristics and the success of theranostics research, there are practical challenges that need to be overcome when considering use of β-emitters for surgical radioguidance. In this position paper, the EANM identifies the possibilities and challenges that relate to the successful implementation of β-emitters in surgical guidance, covering aspects related to instrumentation, radiation protection, and modes of implementation.
A comparative analysis of foraging route development by bumblebees and honey bees
Authors: Buatois Alexis , Mailly Juliane , Dubois Thibault , Lihoreau Mathieu 
Published: January 2024

AbstractMany pollinators, such as bees, hummingbirds and bats, use multi-destination routes (traplines) to exploit familiar plant resources. However, it is not clear to what extent the mechanisms underpinning trapline development and optimisation are comparable across species. Here we compared route formation, repeatability and efficiency by foragers of two social bee species, the solo foraging bumblebee Bombus terrestris and the mass foraging honey bee Apis mellifera, in the same laboratory conditions. In a simple routing task (with four artificial flowers), all bumblebees and honey bees developed a route, although honey bees were slower to do so. In a more complex routing task (with six flowers), however, only bumblebees developed a route between the 6 flowers. Honey bees took a longer time to discover all flowers and developed routes between fewer flowers. Comparing bumblebees and honey bees using the same experimental paradigm thus revealed key behavioural differences likely resulting from their contrasting collective foraging strategies.
Psychotherapie wirkt
Authors: Flückiger Christoph , Willutzki Ulrike , grosse Holtforth Martin , Wampold Bruce E. 
Published: January 2024

ZusammenfassungPsychotherapie ist eine kooperative und individualisierte Behandlung zur Förderung der psychischen Gesundheit, die sich in (post-)modernen Gesellschaften weiterentwickelt. Psychotherapieerfolg umfasst ein breites Spektrum von Kriterien, wie beispielsweise die Verringerung von symptombezogenem Leidensdruck sowie die Förderung von Wohlbefinden, persönlichen Werten, Stärken und psychosozialer Partizipation. Es liegen umfangreiche metaanalytische Belege dafür vor, dass Psychotherapie bei den häufigsten psychischen Störungen und deren Komorbidität bemerkenswert gut und stabil wirkt. Darüber hinaus gibt es eine Vielzahl metaanalytischer Belege für die potenzielle Relevanz transtheoretischer Beziehungs- und Wirkprinzipien. Ausgehend von der Darstellung des sich kontinuierlich entwickelnden evidenzbasierten Konsolidierungsprozesses werden im vorliegenden Beitrag Schlussfolgerungen für die zukünftige Aus- und Weiterbildung sowie die Praxis einer transtheoretisch orientierten Psychotherapie gezogen. Der Beitrag schließt mit allgemeineren Hinweisen auf zukünftige Ziele in transtheoretischer Psychotherapie.
Lipschitz-agnostic, efficient and accurate rendering of implicit surfaces
Authors: Winchenbach Rene , Möller Michael , Kolb Andreas 
Published: January 2024

AbstractIn this paper, we propose an accurate and controllable rendering process for implicit surfaces with no or unknown analytic Lipschitz constants. Our process is built upon a ray-casting approach where we construct an adaptive Chebyshev proxy along each ray to perform an accurate intersection test via a robust and multi-stage searching method. By taking into account approximation errors and numerical conditions, our methods comprise several pre-conditioning and post-processing stages to improve the numerical accuracy, which potentially applied recursively. The intersection search is performed by evaluating a QR decomposition on the Chebyshev proxy function, which can be done in a numerically accurate way. Our process achieves comparable accuracy to other techniques that impose more constraints on the surface, e.g., knowledge of Lipschitz constants, and higher accuracy compared to approaches that impose similar constraints as our approach.
Genetic profile of syndromic retinitis pigmentosa in Portugal
Authors: Cortinhal Telmo , Santos Cristina , Vaz-Pereira Sara , Marta Ana , Duarte Lilianne , Miranda Vitor , Costa José , Sousa Ana Berta , Peter Virginie G. , Kaminska Karolina , Rivolta Carlo , Carvalho Ana Luísa , Saraiva Jorge , Soares Célia Azevedo , Silva Rufino , Murta Joaquim , Santos Luísa Coutinho , Marques João Pedro 
Published: January 2024

Abstract
Purpose
Retinitis pigmentosa (RP) comprises a genetically and clinically heterogeneous group of inherited retinal degenerations, where 20–30% of patients exhibit extra-ocular manifestations (syndromic RP). Understanding the genetic profile of RP has important implications for disease prognosis and genetic counseling. This study aimed to characterize the genetic profile of syndromic RP in Portugal.

Methods
Multicenter, retrospective cohort study. Six Portuguese healthcare providers identified patients with a clinical diagnosis of syndromic RP and available genetic testing results. All patients had been previously subjected to a detailed ophthalmologic examination and clinically oriented genetic testing. Genetic variants were classified according to the American College of Medical Genetics and Genomics; only likely pathogenic or pathogenic variants were considered relevant for disease etiology.

Results
One hundred and twenty-two patients (53.3% males) from 100 families were included. Usher syndrome was the most frequent diagnosis (62.0%), followed by Bardet-Biedl (19.0%) and Senior-Løken syndromes (7.0%). Deleterious variants were identified in 86/100 families for a diagnostic yield of 86.0% (87.1% for Usher and 94.7% for Bardet-Biedl). A total of 81 genetic variants were identified in 25 different genes, 22 of which are novel. USH2A and MYO7A were responsible for most type II and type I Usher syndrome cases, respectively. BBS1 variants were the cause of Bardet-Biedl syndrome in 52.6% of families. Best-corrected visual acuity (BCVA) records were available at baseline and last visit for 99 patients (198 eyes), with a median follow-up of 62.0 months. The mean BCVA was 56.5 ETDRS letters at baseline (Snellen equivalent ~ 20/80), declining to 44.9 ETDRS letters (Snellen equivalent ~ 20/125) at the last available follow-up (p < 0.001).

Conclusion
This is the first multicenter study depicting the genetic profile of syndromic RP in Portugal, thus contributing toward a better understanding of this heterogeneous disease group. Usher and Bardet-Biedl syndromes were found to be the most common types of syndromic RP in this large Portuguese cohort. A high diagnostic yield was obtained, highlighting current genetic testing capabilities in providing a molecular diagnosis to most affected individuals. This has major implications in determining disease-related prognosis and providing targeted genetic counseling for syndromic RP patients in Portugal.
Single-session measures of quadriceps neuromuscular function are reliable in healthy females and unaffected by age
Authors: O’Bryan Steven J. , Hiam Danielle , Lamon Séverine 
Published: January 2024

Abstract
Purpose
This study aimed to determine the inter-session reliability of quadriceps neuromuscular function measurements in healthy young and older females.

Methods
Twenty-six females aged 19–74 years completed two identical experimental sessions on different days. Quadriceps neuromuscular function measurements included isometric maximal voluntary force, high- and low-frequency twitch force, voluntary and evoked (H-reflex, M-wave) electromyography (EMG), and estimated maximal torque, velocity and power derived from torque–velocity relationships. Intra-class correlation coefficients (ICCs), coefficients of variation (CoV) and Bland–Altman plots assessed inter-session reliability. The effect of age on reliability was assessed by linear regression.

Results
Excellent reliability (ICC > 0.8) was shown for all voluntary and evoked mechanical outcomes. Vastus lateralis EMG outcomes showed excellent reliability (ICC > 0.8) with CoVs < 12%, which were better than those of vastus medialis and rectus femoris. Age was not associated with reliability for 27/28 outcomes (P > 0.05).

Conclusion
Excellent reliability of voluntary and evoked force and vastus lateralis EMG outcomes measured in healthy females can be attained in one experimental session, irrespective of age. Female neuromuscular function can be accurately assessed across the lifespan with minimal inconvenience, increasing feasibility for future research. The random error should however be considered when quantifying age-related differences in neuromuscular function.
Electrical Cardiometry during transition and short-term outcome in very preterm infants: a prospective observational study
Authors: Schwarz C. E. , O’Toole J. M. , Healy D. B. , Panaviene J. , Livingstone V. , Dempsey E. M. 
Published: January 2024

AbstractThe purpose of this study is to evaluate the association of Electrical Cardiometry (EC)-derived cardiac output indexed to weight (CO) and its changes during the first 48 h in relation to adverse short-term outcome in very preterm infants. In this prospective observational study of preterm infants < 32 weeks gestational age (GA), the combined adverse outcome was defined as mortality or abnormal cranial ultrasound (any grade intracranial hemorrhage (ICH) or periventricular leukomalacia) within the first 2 weeks postnatally. Logistic regression models were used to investigate the association between median CO and outcome and mixed-effects models for the time trajectory of CO. In the absence of device-specific thresholds for low or high CO, no thresholds were used in our analysis. Fifty-three infants (median (IQR) GA 29.0 (25.4–30.6) weeks, birthweight 1020 (745–1505) g) were included in the analysis. Median CO was 241 (197–275) mL/kg/min for the adverse outcome and 198 (175–227) mL/kg/min for normal outcome (odds ratio (OR) (95% confidence interval (95% CI)), 1.01 (1.00 to 1.03); p = 0.028). After adjustment for GA, the difference was not significant (adjusted OR (95% CI), 1.01 (0.99 to 1.02); p = 0.373). CO trajectory did not differ by outcome (p = 0.352). A post hoc analysis revealed an association between CO time trajectory and ICH ≥ grade 2. Conclusions: EC-derived CO estimates within 48 h postnatally were not independently associated with brain injury (any grade) or mortality in the first 14 days of life. CO time trajectory was found to be associated with ICH ≥ grade 2.

What is Known:• Bioreactance-derived cardiac output indexed to bodyweight (CO) in the transitional period has been associated with adverse short-term outcome in preterm infants.

What is New:• Electrical Cardiometry (EC)-derived CO measurements in very preterm infants during the transitional period are not independently associated with adverse outcome (death or ultrasound detected brain damage) within 2 weeks postnatally.• In the first 48 h EC-derived CO increases over time and is higher in extremely preterm infants compared to very preterm and differs from previously reported bioreactance-derived CO values.
Predictive Factors for Successful Decannulation in Patients with Tracheostomies and Brain Injuries: A Systematic Review
Authors: Gallice Thomas , Cugy Emmanuelle , Branchard Olivier , Dehail Patrick , Moucheboeuf Geoffroy 
Published: January 2024

AbstractNeurological patients frequently have disorders of consciousness, swallowing disorders, or neurological states that are incompatible with extubation. Therefore, they frequently require tracheostomies during their stay in an intensive care unit. After the acute phase, tracheostomy weaning and decannulation are generally expected to promote rehabilitation. However, few reliable predictive factors (PFs) for decannulation have been identified in this patient population. We sought to identify PFs that may be used during tracheostomy weaning and decannulation in patients with brain injuries. We conducted a systematic review of the literature regarding potential PFs for decannulation; searches were performed on 16 March 2021 and 1 June 2022. The following databases were searched: MEDLINE, EMBASE, CINAHL, Scopus, Web of Science, PEDro, OPENGREY, OPENSIGLE, Science Direct, CLINICAL TRIALS and CENTRAL. We searched for all article types, except systematic reviews, meta-analyses, abstracts, and position articles. Retrieved articles were published in English or French, with no date restriction. In total, 1433 articles were identified; 26 of these were eligible for inclusion in the review. PFs for successful decannulation in patients with acquired brain injuries (ABIs) included high neurological status, traumatic brain injuries rather than stroke or anoxic brain lesions, younger age, effective swallowing, an effective cough, and the absence of pulmonary infections. Secondary PFs included early tracheostomy, supratentorial lesions, the absence of critical illness polyneuropathy/myopathy, and the absence of tracheal lesions. To our knowledge, this is the first systematic review to identify PFs for decannulation in patients with ABIs. These PFs may be used by clinicians during tracheostomy weaning.
Gastrointestinal involvement in STEC-associated hemolytic uremic syndrome: 10 years in a pediatric center
Authors: Giordano Mario , Iacoviello Onofrio , Santangelo Luisa , Martino Marida , Torres Diletta , Carbone Vincenza , Scavia Gaia , Loconsole Daniela , Chironna Maria , Cristofori Fernanda , Francavilla Ruggiero 
Published: January 2024

Abstract
Background
The gastrointestinal (GI) tract represents one of the main targets of typical hemolytic uremic syndrome (HUS) in children. In this observational study, we tried to establish (1) the main features of GI complications during STEC-HUS and (2) the relationship between Escherichia coli serotypes and Shiga toxin (Stx) variants with hepatopancreatic involvement.

Methods
A total of 79 STEC-HUS patients were admitted to our pediatric nephrology department between January 2012 and June 2021. Evidence of intestinal, hepatobiliary, and pancreatic involvements was reported for each patient, alongside demographic, clinical, and laboratory features. Frequency of gastrointestinal complications across groups of patients infected by specific E. coli serotypes and Stx gene variants was evaluated.

Results
Six patients developed a bowel complication: two developed rectal prolapse, and four developed bowel perforation which resulted in death for three of them and in bowel stenosis in one patient. Acute pancreatitis was diagnosed in 13 patients. An isolated increase in pancreatic enzymes and/or liver transaminases was observed in 41 and 15 patients, respectively. Biliary sludge was detected in three, cholelithiasis in one. Forty-seven patients developed direct hyperbilirubinemia. Neither E. coli serotypes nor Shiga toxin variants correlated with hepatic or pancreatic involvement.

Conclusions
During STEC-HUS, GI complications are common, ranging from self-limited elevation of laboratory markers to bowel perforation, a severe complication with a relevant impact on morbidity and mortality. Hepatopancreatic involvement is frequent, but usually short-lasting and self-limiting.

Graphical abstract
“Fear of raising the problem without a solution”: a qualitative study of patients’ and healthcare professionals’ views regarding the integration of routine support for physical activity within breast cancer care
Authors: Gokal K. , Daley A. J. , Madigan C. D. 
Published: January 2024

Abstract
Objective
The benefits of physical activity across the cancer continuum for many adult cancers are well established. However, physical activity is yet to be routinely implemented into health services throughout the world. This study aims to explore patients’ and healthcare professionals’ views about integrating conversations and support for physical activity into routine care during treatment for breast cancer.

Methods
Healthcare professionals and patients from across the UK living with or beyond breast cancer were invited to take part in semi-structured interviews that were conducted online. Recruitment for the study was advertised on social media, in cancer support groups and newsletters. Data were analysed using inductive thematic analysis.

Results
Three themes captured perceptions of integrating support for physical activity in routine breast cancer care among 12 health care professionals (who deliver breast cancer care) and 15 patients. Themes between healthcare professionals and patients overlapped, and therefore, combined themes are presented. These were: (1) current practice; (2) implementation in care and (3) training needs.

Conclusion
Many healthcare professionals who offer cancer care are reluctant to raise the topic of physical activity with patients, yet patients have suggested that they would like additional support to be physically active from their medical team. Providing healthcare professionals with education regarding the benefits of physical activity to reduce the risk of recurrence along with evidence based low-cost, remote interventions would allow them to integrate conversations about physical activity within routine cancer care for all patients.
Alltägliche Wegekopplungen beim Lebensmitteleinkauf: Empirische Erkenntnisse und ihre Relevanz für die angewandte Handelsforschung
Authors: Rauh Jürgen , Rauch Sebastian 
Published: January 2024

ZusammenfassungDie Ausdünnung des stationären Handelsnetzes hat vor allem in ländlichen, dünn besiedelten Räumen, aber auch in städtischen Teilräumen zu beträchtlichen Lücken in der Nahversorgung geführt. Dadurch werden neue Anforderungen an das räumliche Einkaufsverhalten und die Mobilität von Konsument*innen gestellt. Während die allgemeinen Kriterien der Einkaufsstättenwahl durchaus gut belegt sind, ist die Rolle von alltäglichen Wegekopplungen wenig untersucht. In der Standortplanung sind nach wie vor Ansätze und Modelle im Einsatz, die sich an der Nearest-Center-Hypothese orientieren; allerdings werden Lebensmitteleinkäufe relativ häufig in alltägliche Aktivitäten eingebettet. Die vorliegende Arbeit analysiert, welche Rolle alltägliche Wegekopplungen beim Lebensmitteleinkauf haben. Mithilfe einer Haushaltsbefragung (n = 2300) wurde festgestellt, dass ca. 42,5 % der letzten Einkaufwege in Verbindung mit anderen Aktivitäten standen. Weitergehend untersucht wurden die räumlichen Merkmale der erhobenen Einkaufswege und mit welchen soziodemografischen Merkmalen die Einkaufskopplungen in Verbindung stehen. Die Berücksichtigung von Wegekopplungen stellt neue Herausforderungen an die Analyse von Erreichbarkeiten in der Lebensmittelversorgung, aber auch in anderen Bereichen der individuellen Mobilität. Alltägliche Praktiken wie Arbeit oder Freizeitaktivitäten beeinflussen die Wahl des Versorgungsstandortes maßgeblich mit. Die Ergebnisse liefern neue empirische Daten für eine tiefergehende Analyse alltäglicher Aktionsräume und eine Grundlage für weitere Modellierungen im Bereich der Standortanalyse und Marktforschung.
Microvascular status in juvenile Sjögren’s disease: the first nailfold videocapillaroscopy investigation
Authors: Lercara Adriano , Malattia Clara , Hysa Elvis , Gattorno Marco , Cere Andrea , Lavarello Claudio , Vojinovic Tamara , Gotelli Emanuele , Paolino Sabrina , Sulli Alberto , Pizzorni Carmen , Smith Vanessa , Cutolo Maurizio 
Published: January 2024

Abstract
Introduction
Juvenile Sjögren’s disease (jSjD) is a rare autoimmune disease characterized by exocrine gland involvement and systemic manifestations, including small vessel vasculitis and Raynaud’s phenomenon (RP). We aimed to investigate the microvascular status in jSjD patients by nailfold videocapillaroscopy (NVC) and the potential correlations with clinical and serological features.

Methods
Clinical data from thirteen consecutive jSjD patients (11 females and 2 males), with a mean age of 16 ± 4 years, diagnosed before 16 years of age (mean age at diagnosis 12 ± 3) according to the 2016 American College of Rheumatology/EULAR criteria for adult SjD, were collected including age- and sex-matched healthy controls (HCs). Clinical, laboratory, and instrumental data were collected, together with NVC examination. Non-specific and specific NVC parameters were investigated, such as capillary density, capillary dilations, giant capillaries, microhaemorrhages and abnormal shapes. Associations between NVC findings and clinical/serological features were explored and analysed using parametrical and non-parametrical tests.

Results
Capillary density reduction correlated significantly with articular involvement (arthralgias) (p = 0.024). Microhaemorrhages correlated with lower C3 levels (p = 0.034). No specific NVC pattern for jSjD was identified, whereas abnormal capillary shapes were significantly higher in jSjD patients than HCs (p = 0.005). NVC abnormalities were not associated with SjD-specific instrumental tests (biopsy, imaging, Schirmer’s test). RP was present in 8% of jSjD patients.

Conclusions
The reduction of capillary density, as well as microhaemorrhages at NVC analysis, are significantly associated with some clinical aspects like articular involvement and serum biomarkers (C3 reduction). The NVC is suggested as safe and further analysis in jSjD patients.

Key Points• Juvenile Sjögren’s disease (jSjD) exhibits a higher rate of abnormal shapes at nailfold videocapillaroscopy (NVC) compared to matched healthy controls.• Articular involvement in jSjD is significantly associated with a lower capillary number at NVC.• Microhaemorrhages on NVC are associated with lower C3 levels, prompting this finding as a putative novel negative biomarker/prognostic factor for jSjD.
Predicted changes in distribution and richness of wild edible plants under climate change scenarios in northwestern Kenya
Authors: Oluoch Wyclife Agumba , Borgemeister Christian , de Deus Vidal Junior João , Fremout Tobias , Gaisberger Hannes , Whitney Cory , Schmitt Christine B. 
Published: January 2024

AbstractWild edible plants (WEPs) can provide diverse and nutrient-rich food sources that contribute to the health and well-being of communities worldwide. In northwestern Kenya, WEPs are vital dietary components for nomadic pastoral communities with limited access to diverse cultivated food crops. However, the increasing impact of climate change poses a threat to these valuable food resources, and their sustainable utilization remains precarious. Here, we assessed the potentially suitable habitats and richness of 23 selected WEPs in the region using a species distribution modeling (SDM) approach. We used species occurrence points from global databases, a national herbarium, and field surveys and made predictions spanning two future time intervals, 2041–2070 and 2071–2100, across three shared socioeconomic pathways (126, 370, and 585) using bioclimatic variables from five global circulation models. We also included soil and topographic variables in our models. We calibrated maximum entropy models using individually tuned parameters. Our future predictions showed a predominant decline in habitat suitability for half the studied WEPs. The richness of the selected WEPs are predicted to remain rather stable under projected future climates concentrating in southern parts of Turkana County. Conservation and management measures need to consider the changing availability of these valuable resources in order to underpin the dietary diversification of local communities.