bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular characterization of 13 patients with PIK3CA‐related overgrowth spectrum using a targeted deep sequencing approach
Authors: de Kock Leanne , Cuillerier Alexanne , Gillespie Meredith , Couse Madeline , Hartley Taila , Mears Wendy , Bernier Francois P. , Chudley Albert E. , Frosk Patrick , Nikkel Sarah M. , Innes A. Micheil , Lauzon Julie , Thomas Maryann , Guerin Andrea , Armour Christine M. , Weksberg Rosanna , Scott James N. , Watkins Debra , Harvey Shirley , Cytrynbaum Cheryl ,   Care4Rare Canada Consortium, Kernohan Kristin D. , Boycott Kym M. 
Published: November 2023

AbstractActivating variants in the PIK3CA gene cause a heterogeneous spectrum of disorders that involve congenital or early‐onset segmental/focal overgrowth, now referred to as PIK3CA‐related overgrowth spectrum (PROS). Historically, the clinical diagnoses of patients with PROS included a range of distinct syndromes, including CLOVES syndrome, dysplastic megalencephaly, hemimegalencephaly, focal cortical dysplasia, Klippel–Trenaunay syndrome, CLAPO syndrome, fibroadipose hyperplasia or overgrowth, hemihyperplasia multiple lipomatosis, and megalencephaly capillary malformation‐polymicrogyria (MCAP) syndrome. MCAP is a sporadic overgrowth disorder that exhibits core features of progressive megalencephaly, vascular malformations, distal limb malformations, cortical brain malformations, and connective tissue dysplasia. In 2012, our research group contributed to the identification of predominantly mosaic, gain‐of‐function variants in PIK3CA as an underlying genetic cause of the syndrome. Mosaic variants are technically more difficult to detect and require implementation of more sensitive sequencing technologies and less stringent variant calling algorithms. In this study, we demonstrated the utility of deep sequencing using the Illumina TruSight Oncology 500 (TSO500) sequencing panel in identifying variants with low allele fractions in a series of patients with PROS and suspected mosaicism: pathogenic, mosaic PIK3CA variants were identified in all 13 individuals, including 6 positive controls. This study highlights the importance of screening for low‐level mosaic variants in PROS patients. The use of targeted panels with deep sequencing in clinical genetic testing laboratories would improve diagnostic yield and accuracy within this patient population.
Interfacial Preparation of Polyoxometalate‐Based Hybrid Supramolecular Polymers by Orthogonal Self‐Assembly
Authors: Xia Zhiqin , Song Yu‐Fei , Shi Shaowei 
Published: November 2023

AbstractThe construction of organic–inorganic hybrid supramolecular polymers using polyoxometalate (POM) as building block is expected to bring new opportunities to the functionalization of supramolecular polymers and the development of novel POM‐based soft materials. Here, by using the orthogonal self‐assembly based on host–guest interactions and metal‐ligand interactions, we report the in situ construction of a novel POM‐based hybrid supramolecular polymer (POM‐SP) at the oil‐water interface, while the redox and competitive responsiveness can be triggered independently. Moreover, the binding energy of POM‐SP at the interface is sufficiently strong so that the assembly of POM‐SP jams, allowing the stabilization of liquids in nonequilibrium shapes, offering the possibility of fabricating all‐liquid constructs with reconfigurability.
Tailored Zwitterionic Hemicyanine Reporters for Early Diagnosis and Prognostic Assessment of Acute Renal Failure
Authors: Zhou Ya , Zhu Lijuan , Liu Biaoxiang , Xu Weiping , Yang Xingyue , Liu Yi , Ruan Bankang , Yi Shujuan , Liang Baoshuai , Dong Guoqi , Huang Jiaguo 
Published: November 2023

AbstractDrug‐induced renal failure (DIRF) poses a serious medical complication with high mortality risk. However, early diagnosis or prognosis of DIRF remain challenging, as current methods rely on detecting late‐stage biomarkers. Herein we present a library of zwitterionic unimolecular hemicyanines (ZCs) available for constructing activatable reporters to detect DIRF since its initial stage. Zwitterionic properties of these probes are achieved through interspersedly integrating alkyl sulfonates and quaternary ammonium cations onto hemicyanine skeleton, which result in record low plasma protein binding (<5 %) and remarkable renal clearance efficiencies (≈96 %). An activatable reporter ZCRR is further developed by masking the optimal candidate ZC6 with a tetrapeptide specifically cleavable by caspase‐8, an initiating indicator of apoptosis. In living mice with cisplatin‐induced DIRF, systematically administered ZCRR efficiently accumulates in kidneys and responds to elevated caspase‐8 for near‐infrared fluorescence signals ‘turn‐on’, enabling sensitive detection of intrarenal apoptosis 60 h earlier than clinical methods, and precise evaluation of apoptosis remediation effects by different medications on DIRF mice. As it's urinary excretable, ZCRR also allows for remote detection of DIRF and predicting renoprotective efficacy through in vitro optical urinalysis. This study thus presents unimolecular renal clearable scaffolds that are applicable to developing versatile activatable reporters for renal diseases management.
Preparation and performance of ceramifiable flame‐retardant silicone sealant
Authors: Wu Xuan , Wang Shiwei , Guo Lu , Xie Weizhen , Zhao Bo , Liu Man , Yin Chaolu , Li Qian 
Published: November 2023

AbstractA ceramifiable and flame‐retardant silicone sealant was prepared by adding aluminum oxide and crosslinkers, coupling agents, and catalysts into hydroxy silicone oil. After ablation at 1000°C for half an hour, a ceramic shell with a certain strength was obtained. The impacts of the viscosity of the hydroxy silicone oil and the content of aluminum oxide on the flame‐retardant properties, mechanical properties, surface properties, and ceramification compressive strength of the composite material were studied. The composite with the highest aluminum oxide content could reach an FV‐1 vertical flame rating and a limiting oxygen index of 29.6%, and the ceramification compressive strength could reach 0.15 MPa. This ceramifiable has a wide range of application prospects in industries such as building decoration and wire and cable.
High‐performance poly(methylsilane arylether arylacetylene) resins with low curing temperatures and weak secondary relaxations
Authors: Li Jixian , Gong Changjun , Lv Shuaikang , Tang Junkun , Yuan Qiaolong , Huang Farong 
Published: November 2023

AbstractA series of poly(methylsilane arylether arylacetylene) (PSEA‐H) resins were synthesized from methyldichlorosilane and isomeric arylether arylacetylenes, and characterized by 1H‐NMR and FT‐IR spectroscopies. The effect of reactive Si‐H groups and the linking positions of benzene rings in the arylether arylacetylene units on the properties of the resins were investigated. The results show that PSEA‐H resins possess good processability with processing windows of over 80°C. The introduction of Si‐H groups reduces the curing temperatures for PSEA‐H resins and weakens the secondary relaxation for the cured PSEA‐H resins. The cured resins and T300 carbon fiber (T300CF) reinforced composites display high mechanical properties. The flexural strengths of a cured PSEA‐H resin and its T300CF composite at room temperature reach 64.2 and 426.5 MPa, respectively. The flexural properties depend on the linking positions of benzene rings. The cured PSEA‐H resins show excellent heat resistance with a temperature of 5% weight loss (Td5) above 500°C.
Facile preparation of diblock copolymers as functional surfaces for protein chromatography
Authors: K. Moorthy Raghu , D'Souza Serena , Sunthar P. , Noronha Santosh B. 
Published: November 2023

AbstractStationary phase plays a crucial role in the operation of a protein chromatography column. Conventional resins composed of acrylic polymers and their derivatives contribute to heterogeneity of the packing of stationary phase inside these columns. Alternative polymer combinations through customized surface functionalization schemes which consist of multiple steps using static coating techniques are well known. In comparison, it is hypothesized that single‐step scheme is sufficient to obtain porous adsorbents as stationary phase for tuning surface morphology and protein immobilization. To overcome the challenge of heterogeneous packing and ease of fabrication at laboratory scale, change in the form factor of separation materials has been proposed in the form of functional copolymer surfaces. In the present work, an amphiphilic, block copolymer, poly(methyl methacrylate‐co‐methacrylic acid) has been chosen and fully characterized for its potential usage in protein chromatography. Hydrophilicity of the acrylic copolymer and abundance of carboxyl groups inherently on the copolymer surface have been successfully demonstrated through contact angle measurements, Fourier transform infrared (FTIR) and X‐ray photoelectron spectroscopy (XPS) studies. Morphological studies indicate presence of a microporous region (nearly 1.3 μm average pore size) that could be beneficial as a cation exchange media as part of the stationary phase in protein chromatography.
Homologous Self‐Assembled Superlattices: What Causes their Periodic Polarity Switching?
Authors: Thakur Varun , Benafsha Dor , Turkulets Yury , Azulay Almog R. , Liang Xin , Goldman R. S. , Shalish Ilan 
Published: November 2023

AbstractQuantum semiconductor structures are commonly achieved by bandgap engineering, which relies on the ability to switch from one semiconductor to another during their growth. Growth of a superlattice is typically demanding technologically. In contrast, accumulated evidence points to a tendency among a certain class of multiple‐cation binary oxides to self‐assemble spontaneously as superlattice structures. This class is dubbed the homologous superlattices. For a famous example, when a mixture of indium and zinc is oxidized, the phases of In‐O and ZnO separate in an orderly periodic manner, along the ZnO polar axis, with polarity inversion taking place between consecutive ZnO sections. The same structure is observed when the indium is replaced with other metals, and perhaps even in ZnO alone. This peculiar self‐assembled structure is attracting research over the past decade. The purpose of this study is to gain understanding of the physics underlying the formation of this unique structure. Here, an explanation is proposed for the long‐standing mystery of this intriguing self‐assembly in the form of an electrostatic growth phenomenon and a test of the proposed model is carried out on experimental data.
Nanoprobe Based Information Processing: Nanoprobe‐Electronics
Authors: Yi Bao , You Long , Hong Jeongmin 
Published: November 2023

AbstractWith computational architectures becoming data‐centric and with the rise of in‐memory computing, the role of memory will be ever more crucial. In turn, storing massive amount of data demands for ultra‐low power and non‐volatile types necessitating new memory technologies. Here, a controllable nanoelectromechanical (NEM) spin memory is proposed for compact nonvolatile memory arrays. It combines the advantages of both nanomechanical and spin‐transfer torque (STT) magnetic memory devices to overcome fundamental scalability roadblocks of non‐hybrid alternatives. The hybrid system paves the way to a new memory technology in the regime of sub‐10‐nm lateral size with a sub‐1‐MA cm−2 switching energy.
The current state of anatomy education in United States doctor of physical therapy programs
Authors: Milian Eryn K. , Smith Bryon A. , Costas Alejandro , Wong Marlon L. , Ravelo Daniel , Hartley Gregory W. 
Published: November 2023

AbstractPhysical therapy education has significantly evolved over the past few decades. While gross anatomy is integral to physical therapy education curricula, the current state of anatomy education within these programs is not well understood. The primary purpose of this report was to provide an update on the current state of anatomy education across United States (US) Doctor of Physical Therapy (DPT) programs. A survey was disseminated to all 261 accredited US physical therapy programs. The survey was deployed in November 2020 with a deadline to respond by January 15, 2021. The response rate was 32.6% (85/261). When teaching anatomy, 90.5% of the responding programs used dissection, 71.4% used didactic lectures, 60.7% used computer‐assisted technology, 58% used prosections, 23.8% used plastinated models, and 31% reported using other methods. DPT programs have experienced declines in PhD faculty (15.7%) and Master of Physical Therapy faculty (15.3%) and notable increases in DPT (16.5%) and physician faculty (8.2%) teaching anatomy within DPT programs. Despite greater use of computer‐assisted technologies, these technologies have not replaced donor‐based dissection in DPT programs.
Advances in Difunctionalization of Olefins with Diorganyl Dichalcogenides
Authors: Wang Helin , Nkingwa Alex Adonis , Islam Fawad , Xu Chao , Zeng Qingle 
Published: November 2023

AbstractOrganochalcogen molecules have extensive applications in various fields. They serve as pharmaceuticals, ligands, organocatalysts, agrochemicals, and other functional materials. Difunctionalization of olefins, which belong to a class of multicomponent reactions, is a successful technique for introducing two functional moieties in a single‐step reaction, both in terms of atom economy and step economy. The difunctionalization of olefins with diorganyl dichalcogenides may effectively increase the molecular complexity, which has achieved significant advancements in recent decades. This article describes recent advancements in the difunctionalization of olefins with diorganyl diselenides and diorganyl disulfides.
An analysis of instructor‐ and tablet‐presented conditional discriminations: Fidelity and rapidity
Authors: Kennedy Taylor , Cariveau Tom , Grelck Kathryn , Brown Alexandria , Platt Delanie F. , Ellington Paige 
Published: November 2023

AbstractMatching‐to‐sample arrangements are commonly used to teach conditional discriminations. In these arrangements, instructors must systematically arrange instruction to ensure that a learner's response comes under the intended sources of stimulus control. Given the multitude of instructional considerations, the instructors' procedural fidelity has been a significant concern. Recently, LeBlanc et al. found that brief training and access to enhanced data sheets produced high levels of fidelity with experienced service providers. The current study extended LeBlanc et al. by examining the effects of a similar training on the fidelity and instructional pacing by participants with and without previous experience. The participants' performance was also compared when using a flashcard or binder (i.e., printed) arrays and relative to a tablet‐delivered instructional program. High levels of fidelity were observed following training, although pacing was slow. Slight differences in performance were observed across comparison arrays; nevertheless, the tablet‐based program outperformed instructors.
Indolo[3,2‐b]indole‐based multi‐resonance emitters for efficient narrowband pure‐green organic light‐emitting diodes
Authors: Jing Yan‐Yun , Yang Yiyu , Li Nengquan , Ye Zeyuan , Wang Xinzhong , Cao Xiaosong , Yang Chuluo 
Published: November 2023

AbstractOrganic light‐emitting diodes (OLEDs) utilizing multi‐resonance (MR) emitters show great potential in ultrahigh‐definition display benefitting from superior merits of MR emitters such as high color purity and photoluminescence quantum yields. However, the scarcity of narrowband pure‐green MR emitters with novel backbones and facile synthesis has limited their further development. Herein, two novel pure‐green MR emitters (IDIDBN and tBuIDIDBN) are demonstrated via replacing the carbazole subunits in the bluish‐green BCzBN skeleton with new polycyclic aromatic hydrocarbon (PAH) units, 5‐phenyl‐5,10‐dihydroindolo[3,2‐b]indole (IDID) and 5‐(4‐(tert‐butyl)phenyl)‐5,10‐dihydroindolo[3,2‐b]indole (tBuIDID), to simultaneously enlarge the π‐conjugation and enhance the electron‐donating strength. Consequently, a successful red shift from aquamarine to pure‐green is realized for IDIDBN and tBuIDIDBN with photoluminescence maxima peaking at 529 and 532 nm, along with Commission Internationale de l'Eclairage (CIE) coordinates of (0.25, 0.71) and (0.28, 0.70). Furthermore, both emitters revealed narrowband emission with small full width at half‐maximum (FWHM) below 28 nm. Notably, the narrowband pure‐green emission was effectively preserved in corresponding devices, which afford elevated maximum external quantum efficiencies of 16.3% and 18.3% for IDIDBN and tBuIDIDBN.
Football group draw probabilities and corrections
Authors: Roberts Gareth O. , Rosenthal Jeffrey S. 
Published: November 2023

AbstractThis article considers the challenge of designing football group draw mechanisms, which have a uniform distribution over all valid draw assignments, but are also entertaining, practical and transparent. Although this problem is trivial in completely symmetric problems, it becomes challenging when there are draw constraints that are not exchangeable across each of the competing teams, so that symmetry breaks down. We explain how to simulate the FIFA sequential draw method and compute the nonuniformity of its draws by comparison with a uniform rejection sampler. We then propose several practical methods of achieving the uniform distribution while still using balls and bowls in a way which is suitable for a televised draw. The solutions can also be carried out interactively. The general methodology we provide can readily be transported to different competition draws and is not restricted to football events.
Does breast cancer modify the long‐term relationship between lifestyle behaviors and mortality? A prospective analysis of breast cancer survivors and population‐based controls
Authors: Gali Kathleen , Orban Ester , Ozga Ann‐Kathrin , Möhl Annika , Behrens Sabine , Holleczek Bernd , Becher Heiko , Obi Nadia , Chang‐Claude Jenny 
Published: November 2023

AbstractBackgroundModifiable lifestyle factors are known to impact survival. It is less clear whether this differs between postmenopausal women ever diagnosed with breast cancer and unaffected women.MethodsWomen diagnosed with breast cancer and unaffected women of comparable age were recruited from 2002 to 2005 and followed up until 2020. Using baseline information, a lifestyle adherence score (range 0–8; categorized as low [0–3.74], moderate [3.75–4.74], and high [≥4.75]) was created based on the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations. Cox regression and competing risks analysis were used to analyze the association of adherence to WCRF/AICR lifestyle recommendations with overall mortality and with death due to cardiovascular diseases and cancer, respectively.ResultsA total of 8584 women were included (2785 with breast cancer and 5799 without). With a median follow‐up of 16.1 years there were 2006 total deaths. Among the deaths of known causes (98.6%), 445 were cardiovascular‐related and 1004 were cancer‐related. The average lifestyle score was 4.2. There was no differential effect of lifestyle score by case‐control status on mortality. After adjusting for covariates, moderate (hazard ratio [HR], 0.66; 95% confidence interval [CI], 0.57–0.76) and high (HR, 0.54; 95% CI, 0.47–0.63) adherence to WCRF/AICR lifestyle recommendations were significantly associated with a decrease in overall mortality. Similarly, in competing risks analysis, moderate and high adherence were associated with decreased mortality from cardiovascular diseases and from cancer.ConclusionsA healthy lifestyle can substantially reduce mortality risk in women. With low adherence to all WCRF/AICR guidelines in about a third of study participants, health interventions are warranted.
Individualized targeted treatment in a case of a rare TFG::ROS1 fusion positive inflammatory myofibroblastic tumor (IMT)
Authors: Sommer Sebastian , Schmutz Maximilian , Schaller Tina , Mayr Patrick , Dintner Sebastian , Märkl Bruno , Huss Ralf , Golas M. Monika , Kuhlen Michaela , Jordan Frank , Claus Rainer , Heinrich Bernhard 
Published: November 2023

AbstractBackgroundInflammatory myofibroblastic tumor (IMTs) are rare mesenchymal neoplasms with slow growth. Resection is considered as therapeutic standard, with chemotherapy being insufficiently effective in advanced disease. ALK translocations are present in 50% of cases, ROS1 fusions (YWHAE::ROS1, TFG::ROS1) are extremely rare. Here, we present a case with TFG::ROS1 fusion and highlight the significance of molecular tumor boards (MTBs) in clinical precision oncology for post‐last‐line therapy.Case PresentationA 32‐year‐old woman presented with IMT diagnosed at age 27 for biopsy and treatment evaluation. Previous treatments included multiple resections and systemic therapy with vinblastine, cyclophosphamide, and methotrexate. A computed tomography scan showed extensive tumor infiltration of the psoas muscles and the posterior abdomen. Next generation sequencing revealed an actionable ROS1 fusion (TFG::ROS1) with breakpoints at exon 4/35 including the kinase domain and activating the RAS‐pathway. TFG, the Trk‐fused gene, exerts functions such as intracellular trafficking and exhibits high sequence homology between species. Based on single reports about efficacy of ROS1‐targeting in ROS1 translocation positive IMTs the patient was started on crizotinib, an ATP‐competitive small molecule c‐MET, ALK and ROS1‐inhibitor. With a follow‐up of more than 9 months, the patient continues to show a profound response with major tumor regression, improved quality of life and no evidence for severe adverse events.ConclusionThis case underscores the importance of the availability of modern molecular diagnostics and interdisciplinarity in precision oncology to identify rare, disease‐defining genotypes that make an otherwise difficult‐to‐treat disease targetable.
Ditopic Covalent Cage for Ion‐Pair Binding: Influence of Anion Complexation on the Cation Exchange Rate
Authors: Delecluse Magalie , Manick Anne‐Doriane , Chatelet Bastien , Chevallier‐Michaud Sabine , Moraleda Delphine , Riggi Innocenzo de , Dutasta Jean‐Pierre , Martinez Alexandre 
Published: November 2023

AbstractA new hemicryptophane host with a ditopic molecular cavity combining a cyclotriveratrylene (CTV) unit with a tris‐urea moiety was synthesized. The complexation of halides, tetramethylammonium (TMA+) cation, and ion pairs was investigated. A positive cooperativity was observed, since halides display a higher binding constant when a TMA+ cation is already present inside the cage. When TMA+ was complexed alone, a decrease of temperature from 298 K to 230 K was required to switch from a fast to a slow exchange regime on the NMR time scale. Nevertheless, the prior complexation of a halide guest in the lower part of the host resulted in significant decrease of the exchange rate of the subsequent complexation of the TMA+ cation. Under these conditions, the 1H NMR signals characteristic of a slow exchange regime were observed at 298 K. Addition of an excess of salts, increases the ionic strength of the solution, restoring the fast exchange dynamics. This result provides insight on how the exchange rate of a cation guest can be modulated by the complexation of a co‐guest anion.