bluuebunny/crossref_metadata_2025_split huggingface dataset:
What's good for fish is good for fishes: Interspecific consistency of growth, condition, and abundance among glacial lakes
Authors: Euclide Peter T. , Perry Christian , Donabauer Steven B. , Grier Angie , Höök Tomas O. 
Published: December 2023

Abstract

Objective
Fish abundance and growth are regulated by a combination of bottom-up and top-down forces, but many management techniques depend more heavily on the latter. Here, we evaluated whether intersystem variation in nutrient loading and bottom-up forces play more dominant roles in the control of abundance and growth of species across similar lakes than intra- and interspecific compensatory effects. We aimed to assess whether patterns of abundance and growth are consistent among fish species across lakes.

Methods
We tested this by evaluating pairwise comparisons of catch-per-unit-effort, condition, and length-at-age data for 11 common warmwater fish species from 184 mesotrophic and eutrophic glacial lakes in Indiana, United States. We characterized the environmental conditions of each lake using limnological measurements (e.g., chlorophyll-a concentration and surface temperature), lake morphology descriptions (e.g., depth and size), catchment characteristics (e.g., percent agricultural land cover), and nutrient load modeling using the Long-Term Hydrologic Impact Analysis model. Taking a meta-analysis approach, we used effect size calculation from pairwise correlations among lakes to identify environmental and community impacts on species abundance, condition, and length at age.

Result
We demonstrated that there were positive associations among most species comparisons (i.e., multiple species experiencing relatively fast growth in the same lake). Evaluations of environmental conditions among systems suggested that differences in estimated phosphorus input and the limnological measurements of total phosphorus, Secchi depth, and chlorophyll-a concentration were good predictors of length at age and catch per unit effort for fish.

Conclusion
Our results indicated that there is a strong and consistent influence of environmental conditions and bottom-up processes in determining species abundance and growth. This suggests that bottom-up forces and environmental conditions linked to nutrient loading likely determine the upper boundary of fish abundance and growth in these lakes.
Power dynamics and resource dependence: NGO‐government collaboration in Yogyakarta, Indonesia
Authors: Hummel Daniel , Kusumasari Bevaola 
Published: December 2023

AbstractThis study examines the collaboration between non‐governmental organizations (NGOs) and the government in Yogyakarta, Indonesia, to shed light on their dynamics and fill the existing gaps in the literature. Focusing on financial dependence, legitimization, and other motivating factors, this study explores the motivations behind NGO–government collaboration and their practical implications. The utilization of a two‐stage purposive sampling method and conducting interviews with executive directors allowed for a rich and nuanced understanding of the motivations, challenges, and dynamics of NGO‐government collaboration in Yogyakarta, Indonesia. It also uncovers factors such as access to resources, networks, advocacy efforts, and grants and supports that shape collaborative relationships. These findings contribute to the understanding of the relationship between NGOs and the government and provide insights for policymakers and practitioners to foster effective and sustainable partnerships. This study contributes to the existing literature on NGO‐government collaboration and offers valuable implications for future research and policy considerations.
Effect of thermal cycling on open‐hole tensile strength of sustainable composites: An experimental investigation
Authors: Varikkadinmel Binaz , Kaushik Deepak , Singh Inderdeep 
Published: December 2023

AbstractSustainable composites are presently employed in applications where structural demands are minimal. Basalt fiber reinforced PLA (BFPLA) and polybutylene succinate (BFPBS) composites, incorporates bio‐based materials, offer the potential to reduce non‐renewable resource consumption and improve end‐of‐life disposal practices. Given the significance of thermal aging in semi‐structural applications and the necessity for open holes (notches) for installation and assembly, little is known about how thermal cycling (TC) affects the open‐hole strength of sustainable composites. This experimental work establishes a quantitative relationship between open‐hole strength and TC, taking into account varying abrasive waterjet pressures, and explores the impacts of thermal aging on the notch sensitivity, thermal, mechanical, and physical properties. BFPBS displayed better unnotched tensile strength and notched strength than pre‐thermal BFPLA specimens after they have been subjected to 100 TC ranging from −20 to 55°C. Thermal aging significantly influenced notch sensitivity, emphasizing its consideration in evaluating notch performance. This research provides a significant contribution to our current understanding of the effects of thermal aging on sustainable composites, enabling their informed application in a variety of industries and the results highlight their promising potential, in particular BFPBS, as strong alternative for medium load applications.Highlights
Evaluated thermal aging effects on basalt fiber (BF) composites, revealing improved properties in BF/PBS composites after thermal cycles.
Established quantitative link between mechanical behavior and thermal cycling using varying waterjet pressure values.
Basalt fibers enhanced crystallinity and thermal stability of PLA and PBS polymers, showing promise for sustainable composites.
Notch sensitivity impacted by thermal aging, underlining the importance of considering these effects in notch performance evaluation.
BF/PBS composites demonstrated potential as robust alternatives for indoor products and sports equipment.
Caregiver condition management and family functioning after pediatric cancer treatment: Moderation by race and ethnicity
Authors: Perez Megan N. , Deatrick Janet A. , Barakat Lamia P. 
Published: December 2023

AbstractObjectiveEnd of pediatric cancer treatment requires family adjustment. Caregivers who struggle to incorporate the child's condition into family life have poorer family outcomes. To better understand factors that contribute to successful transition off active childhood cancer treatment, we sought to examine caregiver perceived management ability of the youth's condition and family functioning as predictors of caregiver distress, evaluate family functioning as a mediator between perceived ability and distress, and explore race and ethnicity as a moderator between perceived ability and family functioning.MethodsCaregivers (N = 141) completed measures assessing family management (condition management ability; CMA), family functioning, and distress as part of a clinical education and screening program within 1 year of the end of treatment. Bias‐corrected bootstrap regression analyses examined mediation and moderated mediation models with patient race and ethnicity as the moderator.ResultsThe overall mediation model was statistically significant for CMA→family functioning→distress. Race and ethnicity moderated the relationship between CMA and family functioning, but the full model was not significant. CMA was related to family functioning for caregivers of non‐Hispanic white youth, but not caregivers of Hispanic youth. Family functioning was related to distress for all caregivers.ConclusionsFamily functioning serves as an initial intervention target to reduce caregiver distress. Caregiver perceived management ability of their child's condition is a meaningful predictor of family functioning and distress for caregivers of non‐Hispanic white youth, yet CMA may be limited as a screener of family management patterns for diverse populations, and other family management dimension may be more applicable.
The N‐terminal intrinsically disordered region of Ncb5or docks with the cytochrome b5 core to form a helical motif that is of ancient origin
Authors: Benson David R. , Deng Bin , Kashipathy Maithri M. , Lovell Scott , Battaile Kevin P. , Cooper Anne , Gao Philip , Fenton Aron W. , Zhu Hao 
Published: December 2023

AbstractNADH cytochrome b5 oxidoreductase (Ncb5or) is a cytosolic ferric reductase implicated in diabetes and neurological conditions. Ncb5or comprises cytochrome b5 (b5) and cytochrome b5 reductase (b5R) domains separated by a CHORD‐Sgt1 (CS) linker domain. Ncb5or redox activity depends on proper inter‐domain interactions to mediate electron transfer from NADH or NADPH via FAD to heme. While full‐length human Ncb5or has proven resistant to crystallization, we have succeeded in obtaining high‐resolution atomic structures of the b5 domain and a construct containing the CS and b5R domains (CS/b5R). Ncb5or also contains an N‐terminal intrinsically disordered region of 50 residues that has no homologs in other protein families in animals but features a distinctive, conserved L34MDWIRL40 motif also present in reduced lateral root formation (RLF) protein in rice and increased recombination center 21 in baker's yeast, all attaching to a b5 domain. After unsuccessful attempts at crystallizing a human Ncb5or construct comprising the N‐terminal region naturally fused to the b5 domain, we were able to obtain a high‐resolution atomic structure of a recombinant rice RLF construct corresponding to residues 25–129 of human Ncb5or (52% sequence identity; 74% similarity). The structure reveals Trp120 (corresponding to invariant Trp37 in Ncb5or) to be part of an 11‐residue α‐helix (S116QMDWLKLTRT126) packing against two of the four helices in the b5 domain that surround heme (α2 and α5). The Trp120 side chain forms a network of interactions with the side chains of four highly conserved residues corresponding to Tyr85 and Tyr88 (α2), Cys124 (α5), and Leu47 in Ncb5or. Circular dichroism measurements of human Ncb5or fragments further support a key role of Trp37 in nucleating the formation of the N‐terminal helix, whose location in the N/b5 module suggests a role in regulating the function of this multi‐domain redox enzyme. This study revealed for the first time an ancient origin of a helical motif in the N/b5 module as reflected by its existence in a class of cytochrome b5 proteins from three kingdoms among eukaryotes.
Evaluation of SYP‐34773's resistance risk and its impact on the activity of mitochondrial respiratory electron transport chain complex I in Phytophthora litchii
Authors: Li Chengcheng , Fu Yixin , Li Xinyue , Zhang Can , Liu Pengfei , Miao Jianqiang , Liu Xili 
Published: December 2023

AbstractBACKGROUNDSYP‐34773 is a low‐toxicity pyrimidine amine compound, which was synthesized by modifying the lead compound diflumetorim. Previous literature has shown that it can strongly inhibit the mycelial growth of several important plant pathogens, including Phytophthora litchii. However, the resistance risk of SYP‐34773 has not been reported for P. litchii.RESULTSThe mean effective concentration (EC50) value of SYP‐34773 against the mycelial growth of 111 P. litchii isolates was 0.108 ± 0.008 μg mL−1, which can be used as the baseline sensitivity for SYP‐34773 resistance detection in the future. Six mutants were obtained from two parental strain through fungicide induction, whose resistance factors fell between 194‐ and 687‐fold, with stability. Results regarding mycelial growth, sporangial production, sporangial germination, zoospore release, cystspore germination, and pathogenicity showed that the mutants' compound fitness index values were significantly lower than those of their parental isolate. Furthermore, there was no cross‐resistance between SYP‐34773 and diflumetorim in P. litchii. Significant inhibition of the mitochondrial complex I enzyme activity in two wild‐type P. litchii isolates, but not in mutants, was observed upon treatment with SYP‐34773.CONCLUSIONThe resistance risk of SYP‐34773 in P. litchii is moderate, and resistance management strategies should be adopted in field use. SYP‐34773 is a mitochondrial complex I inhibitor, and SYP‐34773‐resistant P. litchii isolates did not show cross‐resistance against diflumetorim. © 2023 Society of Chemical Industry.
Physiologically‐based pharmacokinetic model of sparsentan to evaluate drug–drug interaction potential
Authors: Patel Nikunjkumar K. , Chen Kuan‐Fu , Chen Shang‐Chiung , Liu Kai 
Published: December 2023

AbstractSparsentan is a dual endothelin/angiotensin II receptor antagonist indicated to reduce proteinuria in patients with primary IgA nephropathy at high risk of disease progression. In vitro data indicate that sparsentan is likely to inhibit or induce various CYP enzymes at therapeutic concentrations. Sparsentan as a victim and perpetrator of CYP3A4 mediated drug–drug interactions (DDIs) has been assessed clinically. A mechanistic, bottom‐up, physiologically‐based pharmacokinetic (PK) model for sparsentan was developed based on in vitro data of drug solubility, formulation dissolution and particle size, drug permeability, inhibition and induction of metabolic enzymes, and P‐glycoprotein (P‐gp) driven efflux. The model was verified using clinical PK data from healthy adult volunteers administered single and multiple doses in the fasted and fed states for a wide range of sparsentan doses. The model was also verified by simulation of clinically observed DDIs. The verified model was then used to test various DDI simulations of sparsentan as a perpetrator and victim of CYP3A4 using an expanded set of inducers and inhibitors with varying potency. Additional perpetrator and victim DDI simulations were performed using probes for CYP2C9 and CYP2C19. Simulations were conducted to predict the effect of complete inhibition of P‐gp inhibition on sparsentan absorption and clearance. The predictive simulations indicated that exposure of sparsentan could increase greater than two‐fold if co‐administered with a strong CYP3A4 inhibitor, such as itraconazole. Other potential DDI interactions as victim or perpetrator were all within two‐fold of control. The effect of complete P‐gp inhibition on sparsentan PK was negligible.
Selective Manipulation of the Mitochondria Oxidative Stress in Different Cells Using Intelligent Mesoporous Silica Nanoparticles to Activate On‐Demand Immunotherapy for Cancer Treatment
Authors: Chang Xiaowei , Zhu Zeren , Weng Lin , Tang Xiaoyu , Liu Tao , Zhu Man , Liu Jie , Tang Wenjun , Zhang Yanmin , Chen Xin 
Published: December 2023

AbstractHerein, the vitamin K2 (VK2)/maleimide (MA) coloaded mesoporous silica nanoparticles (MSNs), functional molecules including folic acid (FA)/triphenylphosphine (TPP)/tetrapotassium hexacyanoferrate trihydrate (THT), as well as CaCO3 are explored to fabricate a core‐shell‐corona nanoparticle (VMMFTTC) for on‐demand anti‐tumor immunotherapy. After application, the tumor‐specific acidic environment first decomposed CaCO3 corona, which significantly levitates the pH value of tumor tissue to convert M2 type macrophage to the antitumor M1 type. The resulting VMMFTT would then internalize in both tumor cells and macrophages via FA‐assisted endocytosis and free endocytosis, respectively. These distinct processes generate different amount of VMMFTT in above two cells followed by 1) TPP‐induced accumulation in the mitochondria, 2) THT‐mediated effective capture of various signal ions to cut off signal transmission and further inhibit glutathione (GSH) generation, 3) ions catalyzed reactive oxygen species (ROS) production through Fenton reaction, 4) sustained release of VK2 and MA to further enhance the ROS production and GSH depletion, which caused significant apoptosis of tumor cells and additional M2‐to‐M1 macrophage polarization via different processes of oxidative stress. Moreover, the primary tumor apoptosis further matures surrounding immature dendritic cells and activates T cells to continuously promote the antitumor immunotherapy.
Gut microbiota signatures in inflammatory bowel disease
Authors: Vestergaard Marie Vibeke , Allin Kristine H. , Eriksen Carsten , Zakerska‐Banaszak Oliwia , Arasaradnam Ramesh P. , Alam Mohammad T. , Kristiansen Karsten , Brix Susanne , Jess Tine 
Published: December 2023

AbstractBackgroundInflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), affect millions of people worldwide with increasing incidence.ObjectivesSeveral studies have shown a link between gut microbiota composition and IBD, but results are often limited by small sample sizes. We aimed to re‐analyze publicly available fecal microbiota data from IBD patients.MethodsWe extracted original fecal 16S rRNA amplicon sequencing data from 45 cohorts of IBD patients and healthy individuals using the BioProject database at the National Center for Biotechnology Information. Unlike previous meta‐analyses, we merged all study cohorts into a single dataset, including sex, age, geography, and disease information, based on which microbiota signatures were analyzed, while accounting for varying technical platforms.ResultsAmong 2518 individuals in the combined dataset, we discovered a hitherto unseen number of genera associated with IBD. A total of 77 genera associated with CD, of which 38 were novel associations, and a total of 64 genera associated with UC, of which 28 represented novel associations. Signatures were robust across different technical platforms and geographic locations. Reduced alpha diversity in IBD compared to healthy individuals, in CD compared to UC, and altered microbiota composition (beta diversity) in UC and especially in CD as compared to healthy individuals were found.ConclusionsCombining original microbiota data from 45 cohorts, we identified a hitherto unseen large number of genera associated with IBD. Identification of microbiota features robustly associated with CD and UC may pave the way for the identification of new treatment targets.
A stagnation point flow of cross nanofluid flow: Levenberg Marquardt backpropagation computational approach
Authors: Shoaib Muhammad , Nisar Kottakkaran Sooppy , Raja Muhammad Asif Zahoor , Tabassum Rafia , Sabir Zulqurnain 
Published: December 2023

AbstractIn the present article, the intelligence based numerical investigation by Levenberg–Marquardt algorithm with Back‐propagated Artificial Neural Networks (LMA–BANN) is exploited to analyze the nonlinear radiative stagnation point flow of cross nanofluid system (NRS‐CNFS) past a stretching surface. The designed NRS‐CNFS, initially represented by system of partial differential equations (PDEs), is converted into system of non‐linear ODEs through the applicability of mathematical conversion analysis. The desired reference solution in the form of a dataset for LMA–BANN is achieved from the Adam method for NRS‐CNFS's different scenarios by varying the magnetic parameter (Ha), Prandlt number (Pr), thermal radiation parameter(R), Eckert number (Ec), thermophoresis diffusion coefficients (Nt), and non‐dimensional activation energy (E). The obtained results are construed for the NRS‐CNFS through the performances of the testing, validation, and training. In addition, the comparison is provided using the LMA ‐BANN analysis, which is validated in terms of regression, fitness estimations, and histograms along with MSE performances. Hence, the article provides an impeccable innovative approach to problem‐solving by implementing a soft computation paradigm. It promotes the use of an effective and dependable alternative framework that is based on soft computing environments and emphasizes descriptive analysis to successfully handle the problems brought on by varied physical features.
Original Sin or Wayward Practice? Living Standards as a Trickle-Down, Residual Consideration of Modern Economics
Authors: Samans Richard 
Published: December 2023

AbstractThis chapter investigates whether modern economics’ shortcomings with respect to inclusion, sustainability and resilience—its treatment of living standards as a residual consideration—can be attributed to the original conceptualization of liberal political economy or a subsequent misapplication of its founding principles. It finds that the discipline’s most influential early theorists and codifiers—Adam Smith, John Stuart Mill and Alfred Marshall—explicitly contextualized their insights about the power of market-based resource allocation in a larger perspective and complementary set of prescriptions. These emphasized the important role of institutions—legal and other norms, policy incentives and public administrative capacities in multiple domains—in helping to translate the increased economic growth enabled by market-based resource allocation into broad improvement in social welfare. Each of these pioneers considered increased production and national income, the wealth of a nation, as a means and not an end in itself. Each emphasized that the ultimate purpose of an economy is to advance the material well-being, or standard of living, of society as a whole. The chapter makes extensive reference to their original texts and traces how their shared view of the crucial institutional underpinnings of inclusion, sustainability and resilience got lost in translation during the evolution of eighteenth- and nineteenth-century political economy into twentieth-century economic science.
Conclusion: Building on Keynes’s Middle Way to Renew the Liberal Tradition and Multilateral System in the 21st Century
Authors: Samans Richard 
Published: December 2023

AbstractThis chapter argues that rebalancing liberal economics through the new macroeconomic approach to welfare and institutional economics described in the book would reinforce Keynes’s “Middle Way” reforms of the 1930s, which were aimed at better reconciling capitalism with social justice by maintaining full employment in decent work through robust domestic demand and investor confidence. It would add a systematic institutional dimension to Keynes’s fiscal and monetary strategies, expanding the toolbox available to policymakers to run their economies relatively hot on a sustainable basis through ongoing improvement in the fundamental conditions underpinning of supply and demand rather than the mainly transitory macroeconomic or deregulatory stimulus measures traditionally favoured by the social democratic centre-left and conservative centre-right. Moreover, the Paris climate agreement requires a new Middle Way in economics to be forged over the next generation, this time between environmentally destructive growth and socially destructive stagnation or degrowth. By internalizing the relevant institutional drivers of a just climate transition in macroeconomic theory and policy, the concepts and tools of human-centred economics create the possibility of a such a “neoclassical-Keynesian-ecological synthesis” focused as much on the social and environmental quality of growth as its quantity. Policymakers must abandon the reflex of standard liberal economics to assume, whether explicitly or implicitly, that broad and sustainable progress in household living standards trickles down inevitably from higher national income. A certain intentionality is required to optimize both—a sustained process of institutional deepening and investment to foster movement closer to the frontier of good policy and institutional practice in the aggregate distribution function’s five domains. The chapter concludes by explaining how operationalizing this forgotten aspect of liberal political economy’s founding principles holds the key not only to satisfying societal demands for greater inclusion, sustainability and resilience but also to reversing liberalism’s declining political prospects within countries and the international system.