bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Future of Grocery Retail
Authors: Sandahl Rickard 
Published: October 2023

AbstractMylla.se is a digital marketplacewhere foodproducers sell directly to their markets. Mylla’s mission is to reduce the distance between those producing food and those consuming it. By removing the middlemen, producersget paid better and buyers get a better price. Founder Rickard Sandahl describes how Mylla’s platformfacilitates relationships between producers and consumers which are better for people, the environment, and the local economy.
Musical Scale-Jumping: ‘What a Wonderful World’ from Lysekil to Lviv
Authors: Dodds Phil 
Published: October 2023

AbstractLouis Armstrong’s ‘What a Wonderful World’ exemplifies popular music’s tendency and ability to build from the particular into the general—or to connect the personal to the universal. The lyrics’ logical leap from local observation to general claim is accompanied by several musical features that enable this leap to be landed. The musical transition to what Édouard Glissant calls ‘Whole-World thinking’ also functions in various cover versions of the song, including politically charged live performances at a Swedish climate protest in 2019, and outside Lviv train station (and widely shared on social media) during Russia’s ongoing invasion of Ukraine. This Armstrong classic shows the potential of what might be called musical ‘scale jumping’, following Neil Smith, reorienting audiences to new scales of political contest. It also exemplifies how cultural practices have long been involved in fusing relations between the experiential and the general, or between particular places and what Glissant calls the ‘Whole-World’.
Einleitung
Authors: Körner Theresa 
Published: October 2023

ZusammenfassungAutomatisierte Berichterstattung wird im Journalismus seit 2010 eingesetzt und soll in den kommenden Jahren weitere Verbreitung finden. Die Vorteile für Medienorganisationen sind unter anderem die Schnelligkeit der Nachrichtenerstellung sowie die Möglichkeit, kostengünstig eine große Anzahl an Nachrichten zu produzieren. In welchem Umfang automatisiert generierte Nachrichtenberichterstattung künftig eine Rolle spielen wird, hängt maßgeblich von der Wahrnehmung und dem Vertrauen der Leser:innen in die Verfahren und den Output der Technologie ab. Mit der Arbeit wird eine Verbindung geschaffen zwischen den im Wesentlichen praxisgetriebenen Erkenntnissen zur automatisierten Berichterstattung, den Forschungsergebnissen zur bewerteten Glaubwürdigkeit computergenerierter Nachrichten durch Lesende sowie den Theorien und Modellen der Kommunikationswissenschaft zu Vertrauen in Journalismus.
Forschungsmodell und Ableitung der Forschungsfragen
Authors: Körner Theresa 
Published: October 2023

ZusammenfassungIn diesem Kapitel werden die identifizierten Forschungslücken zusammengefasst, das Forschungsmodell der vorliegenden Arbeit präsentiert sowie die Forschungs- und Detailfragen abgeleitet und konkretisiert. Zur intersubjektiven Überprüfbarkeit der Studie und ihrer Ergebnisse wird die gewählte Methode der Focus Groups in Kapitel 6 dargestellt. Dazu erfolgen zunächst die Begründung der Methodenwahl für das Anliegen dieser Arbeit, die Darstellung und Rekrutierung der Focus Groups sowie die Begründung der Kriterienauswahl. Anschließend wird die Vorbereitung, Durchführung und Auswertung der Erhebungsmethode dokumentiert.
Methodik und Untersuchungsdesign: Focus Groups
Authors: Körner Theresa 
Published: October 2023

ZusammenfassungWie in Kapitel 6 dargestellt und hergeleitet, hat die vorliegende Arbeit im empirischen Teil das wesentliche Anliegen, die Bedeutung von Vertrauen in automatisierten Journalismus für Lesende abzubilden und die Auswirkungen der Spezifikation der automatisierten Berichterstattung auf die Vertrauensbewertung herauszuarbeiten. Zur Beantwortung der forschungsleitenden Fragestellung werden leitfadengestützte Focus Groups als Instrument zur Datenerhebung ausgewählt und die Methode an einigen Stellen individuell für das Forschungsinteresse angepasst. Durchgeführt werden drei Gruppengespräche mit jeweils unterschiedlichen Zielsetzungen. Im folgenden Kapitel wird die Methodenwahl begründet und das Vorgehen dokumentiert. Weitere Dokumente zur intersubjektiven Überprüfbarkeit des Vorgehens sind im Appendix veröffentlicht; an gegebener Stelle wird darauf verwiesen.
Drunk or just putrefied?
Authors: Doerr Adrian A. , Nordmeier Frederike , Walle Nadja , Laschke Matthias W. , Menger Michael D. , Meyer Markus R. , Schmidt Peter H. , Schaefer Nadine 
Published: October 2023

Abstract
Background
Several pitfalls arise in the assessment of postmortem blood alcohol concentrations (BAC). The purpose of the present study was to evaluate in a controlled and systematic manner in a porcine model whether a postmortem congener pattern can provide evidence for antemortem or postmortem ethanol neogenesis.

Methods
Ethanol was administered intravenously to six pigs, whereas six control pigs remained sober. The animals were euthanized 1h after the start of administration, and peripheral and heart blood (HB) as well as muscle tissue were collected. The animals were stored at room temperature and the aforementioned range of samples was collected daily for 3 days. Samples were analyzed for ethanol and congener substances by headspace gas chromatography-mass spectrometry.

Results
Over the course of storage, ethanol formation was observed in the sober pigs, resulting in a median BAC of 0.24 g/kg body weight. The BAC in the pigs with alcohol remained comparatively stable. In addition, a distinct increase in n‑propanol, n‑butanol, and acetaldehyde was observed. The median blood concentration of n‑propanol in sober animals was higher after storage than that of pigs with alcohol, but no significant differences could be substantiated between the two groups (p > 0.05). Acetaldehyde and n‑butanol concentrations in HB of the sober pigs increased to the level of the pigs with alcohol at death after 3 days. Until the end of the experiment (3 days postmortem), no significant differences in concentrations were detected. Concentrations in muscle tissue did not increase to the same extent.

Discussion
In the present study, no marker could be identified that could reliably discriminate antemortem ethanol ingestion from postmortem genesis.
Impact of coronary CT angiography in selection of treatment modalities and subsequent cardiovascular events in Thai patients with stable CAD
Authors: Limpijankit Thosaphol , Jongjirasiri Sutipong , Meemook Krissada , Unwanatham Nattawut , Rattanasiri Sasivimol , Thakkinstian Ammarin , Laothamatas Jiraporn 
Published: October 2023

Abstract
Background
Coronary computed tomography angiography (CCTA) enables improved diagnosis of subclinical, coronary artery disease (CAD). This retrospective cohort study investigated the association between different treatment modalities guided by CCTA and the prevention of major adverse cardiovascular events (MACEs) in patients with stable CAD.

Methods
From 2005 to 2013, a total of 9338 patients, including both asymptomatic individuals with risk factors and symptomatic patients with suspected CAD, who underwent CCTA were analyzed. The patients were categorized into one of three groups based on results of CCTA: obstructive CAD (≥ 50% stenosis in at least one vessel), non-obstructive CAD (1–49% stenosis in at least one vessel), and no observed CAD (0% stenosis). They were subsequently followed up to assess the treatment they received and the occurrence of MACEs (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or late revascularization).

Results
During an average follow-up period of 9.9 ± 2.4 years, patients with obstructive CAD had the highest incidence of MACEs (19.8%), followed by those with non-obstructive CAD and no coronary artery stenosis (10.3 and 5.5%, respectively). After adjusting for confounding variables, it was found that patients treated with statins alone were the least likely to develop MACEs in all three groups, compared to those receiving no treatment, with hazard ratios (95% CI) of 0.43 (0.32, 0.58), 0.47 (0.34, 0.64), and 0.46 (0.31, 0.69), respectively. In patients with obstructive CAD, treatment with a combination of statin and aspirin, or early revascularization was associated with a lower likelihood of experiencing MACEs compared to no treatment with hazard ratios of 0.43 (0.33, 0.58) and 0.64 (0.43, 0.97), respectively.

Conclusion
CCTA offers useful guidance for the treatment of patients with stable CAD and shows potential for prevention of CV events. However, the full validation of a given strategy utilizing CCTA will require a prospective longitudinal study, utilizing a randomized clinical trial design.
Using cryopreserved allogeneic pericardium to repair congenital heart defects in children
Authors: Birbach Mariusz , Fedorowicz Maciej , Gałkowska Ewa M. , Powirska Agnieszka , Kozłowski Michał , Mozol Krzysztof , Wasiak Aleksandra , Maruszewski Bohdan , Kansy Andrzej 
Published: October 2023

AbstractPatches prepared from autologous, allogeneic, or xenogeneic tissues are widely used in the repair of congenital heart defects in children. Since 2002, cryopreserved allogeneic pericardial patches have been prepared in our institution as an alternative to commercially available patches. This study retrospectively reviewed donor and patient data concerning cryopreservation time and the clinical use of the pericardium in 382 children who were operated on at a single center between 2004 and 2021. There were 177 donors: 98 males and 79 females. The median donor age was 13 years (range: 1 month to 53 years) and the median cryopreservation time was 72 days (range: 3–685). There were 382 pediatric patients: 224 males and 158 females. The median patient age was 1 month (range: 3 days to 17.8 years). The patches were used for primary surgeries in 228 patients and for reoperations in 154. The patches were implanted into the right heart or venous circulation in 209 patients, the left heart or arterial circulation in 246 patients, and both sides of the circulatory system in 73. Extracardiac patch implantation was performed in 339 patients, intracardiac in 79 patients, and both intracardiac and extracardiac in 36 patients. Our study presents a single-center experience in the use of cryopreserved allogeneic pericardium. The pericardium can be used on the systemic and pulmonary sides of the circulatory system, in either extracardiac or intracardiac positions. However, there is no uniform strategy for selecting the “patch of choice” for correcting congenital heart defects in children, especially since there are few studies comparing several types of patches.
Usanovich and Nernst colliding: inconsistencies in the all-in-one acid–base concept?
Authors: Flechsig Gerd-Uwe 
Published: October 2023

AbstractAmong the many acid-base concepts, the theory of Usanovich is one of the least known despite the most general scope including almost all chemical reaction types and even redox chemistry. Published 1939 in a Soviet journal in Russian language, it gained little immediate attention, and was later criticized mainly as being too broad in scope. Although several articles recently remembered Usanovich and his acid–base theory, one major inconsistency again was overseen: the electron is put in a row along with anions. Chemical history probably correctly puts this concept aside, also because it added little explanation capabilities beyond the elaborated considerations of the simultaneously published acid–base theory of Gilbert N. Lewis which was later refined by Pearson (hard and soft acids and bases, “HSAB”). A modified version of the core of Usanovich' concept is finally discussed. It combines the classic protic and aprotic acid–base concepts on the foundations of Lewis’ and Pearsons ideas.
Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics
Authors: Dong Min , Liu Ying , Liu Biao , Peng Jin , Tang Yuxia , Lu Guangming , Shi Haibin , Zhu Feipeng 
Published: October 2023

Abstract
Glioma is the most common malignant tumor of the brain and enhancing the efficacy of chemotherapy in glioma is critical for improving patients’ prognosis. In this study, a glioma-targeting drug delivery system is constructed using biodegradable periodic mesoporous organosilica nanoparticles (PMO) that are modified with lactoferrin (Lf) ligands. The obtained PMO is doped with thioether groups and can be degraded in the high concentration of glutathione in tumor cells. The surface area and pore volume of PMO are 772 cm2/g and 0.98 cm3/g, respectively and the loading capacity of doxorubicin (Dox) is as high as 20%. The results of the confocal laser scanning microscope show that the uptake of PMO-Lf@Dox by C6 cells is higher than PMO@Dox. The quantitative analysis of the flow cytometer further demonstrates that more PMO-Lf@Dox enter C6 cells, indicating that the modification of lactoferrin can significantly increase the uptake of C6 cells. Finally, the therapeutic efficacy results show that Lf-modified PMO enhances the inhibitory effect of Dox on C6 cells when incubated for 24 h and 72 h. In summary, this lactoferrin receptor-mediated PMO drug carrier with biodegradability in glutathione in tumor cells can be used to enhance drug delivery into glioma without long-term accumulation in vivo.

Graphical abstract
Agreement of zero-heat-flux thermometry with the oesophageal and tympanic core temperature measurement in patient receiving major surgery
Authors: Liang Hao , Wang Jing-Yan , Liang Yan , Shao Xin-Feng , Ding Yan-Ling , Jia Hui-Qun 
Published: October 2023

AbstractTo identify and prevent perioperative hypothermia, most surgical patients require a non-invasive, accurate, convenient, and continuous core temperature method, especially for patients undergoing major surgery. This study validated the precision and accuracy of a cutaneous zero-heat-flux thermometer and its performance in detecting intraoperative hypothermia. Adults undergoing major non-cardiac surgeries with general anaesthesia were enrolled in the study. Core temperatures were measured with a zero-heat-flux thermometer, infrared tympanic membrane thermometer, and oesophagal monitoring at 15-minute intervals. Taking the average value of temperature measured in the tympanic membrane and oesophagus as a reference, we assessed the agreement using the Bland-Altman analysis and linear regression methods. Sensitivity, specificity, and predictive values of detecting hypothermia were estimated. 103 patients and one thousand sixty-eight sets of paired temperatures were analyzed. The mean difference between zero-heat-flux and the referenced measurements was -0.03 ± 0.25 °C, with 95% limits of agreement (-0.52 °C, 0.47 °C) was narrow, with 94.5% of the differences within 0.5 °C. Lin’s concordance correlation coefficient was 0.90 (95%CI 0.89–0.92). The zero-heat-flux thermometry detected hypothermia with a sensitivity of 82% and a specificity of 90%. The zero-heat-flux thermometer is in good agreement with the reference core temperature based on tympanic and oesophagal temperature monitoring in patients undergoing major surgeries, and appears high performance in detecting hypothermia.
Low-magnitude seismic swarms in the Calabrian Arc (Italy)
Authors: Chiappetta Giuseppe Davide , La Rocca Mario 
Published: October 2023

AbstractSeismic swarms of low magnitude earthquakes occur frequently in the Calabrian Arc. During the last few years, several earthquakes of magnitude up to ML4.4 occurred both on land and offshore near the coast of Calabria. Some of them were followed by a sequence of tens to hundreds of smaller, well-clustered earthquakes that occurred during the following weeks or months. In other cases, swarms of low-magnitude earthquakes occur without a classical mainshock-aftershock evolution. In this work, we selected swarms that were well recorded by a high number of seismic stations to perform a detailed analysis consisting of the determination of the relative location and focal mechanism for as many earthquakes as possible. In some cases, the relative location allows to recognize the seismogenic fault and to distinguish the fault plane from the auxiliary plane of the focal mechanism solution. In other cases, the relative location unravels a small cloud of events that is not compatible with a unique fault plane, suggesting the occurrence of the swarm in highly fractured seismogenic volume. The relative hypocenter positions allow to estimate the size of the seismogenic volume, which is very small in most of the cases, often less than 1 km3. However, its extension is greater than the size computed for the mainshock rupture in many cases. The most common source mechanism is of normal type, but strike-slip and reverse kinematics are also found, in particular for swarms located offshore and near the coast. The temporal distribution of events does not show any evident migration of the sources, thus suggesting that the driving mechanism is not related with aseismic phenomena like fluid diffusion and stress waves.
Digitally nudging users to explore off-profile recommendations: here be dragons
Authors: Alves Gabrielle , Jannach Dietmar , de Souza Rodrigo Ferrari , Damian Daniela , Manzato Marcelo Garcia 
Published: October 2023

AbstractIn many application domains of recommender systems, e.g., on media streaming sites, one main goal of the provider of the recommendation service is to increase the engagement of users by helping themdiscovernew types of content they like. Standard collaborative filtering algorithms by design often lead to a certain level of discovery. Nonetheless, in certain domains, it may be helpful to more actively promote content to users beyond their past preference profile (“off-profile”) and thereby help users explore new content. However, when showing such off-profile content to users in combination with more familiar content, the new content items may be overlooked. In this research, we explore to what extentdigital nudging, i.e., subtly directing user choices in a specific direction, can help to raise the attention and interest of users for off-profile content. We conducted a user study ($$N=1064$$N=1064) on a real-world social book recommendation app. We find that users who are nudged towards recommended books of their non-preferred genres significantly more often put these off-profile books on their reading lists, thus confirming the effectiveness of digital nudging in this application. However, we also found that digital nudges may negatively impact the users’ beliefs and attitudes towards the system and a more limited intention to use the system in the future. As a result, we find that digital nudging in recommendations, while effective in the short run, must be done with due care, keeping an eye on the overall quality perceptions by users and potentially harmful long-term effects.
Developing a digital tutor as an intermediary between students, teaching assistants, and lecturers
Authors: Hobert Sebastian , Berens Florian 
Published: October 2023

AbstractIndividualized learning support is an essential part of formal educational learning processes. However, in typical large-scale educational settings, resource constraints result in limited interaction among students, teaching assistants, and lecturers. Due to this, learning success in those settings may suffer. Inspired by current technological advances, we transfer the concept of chatbots to formal educational settings to support not only a single task but a full lecture period. Grounded on an expert workshop and prior research, we design a natural language-based digital tutor acting as an intermediary among students, teaching assistants, and lecturers. The aim of the digital tutor is to support learners automated during the lecture period in natural language-based chat conversations. We implement a digital tutor in an iterative design process and evaluate it extensively in a large-scale field setting. The results demonstrate the applicability and beneficial support of introducing digital tutors as intermediaries in formal education. Our study proposes the concept of using digital tutors as intermediaries and documents the development and underlying principles.
Heavy Metal Levels and Cancer Risk Assessments of the Commercial Denis, Sparus aurata Collected from Bardawil Lake and Private Fish Farm Waters as a Cultured Source, Egypt
Authors: Abbas Mahmoud Mahrous M. 
Published: October 2023

AbstractHeavy metal pollution of natural and cultivated habitats may be caused by agricultural, industrial, and human activities. Fish living in these habitats easily accumulate metals in their organs; for food safety and human health, the heavy metals in fish flesh are of major concern due to the harmful nature of these pollutants even in low quantities. In this study, metals (Iron, Fe; Lead, Pb; Cadmium, Cd; Nickel, Ni; Copper, Cu and Zinc, Zn) in the muscle, liver, intestine, and gill of gilthead seabream (Sparus aurata, Denis is local name) were monitored to determine the contamination levels and to investigate the protective impact of cooking methods on the reduction or mitigation of metal levels. Although the Denis samples exhibited relatively low Pb and Cd levels, most fish samples had elevated levels of Fe and Zn. The examined metals accumulated at the highest level in the liver and gills compared to the other organs. Results showed that cooking methods had a considerable effect on concentrations of metals. However, the levels of metal in S. aurata from various sources were reduced significantly (P < 0.05) by frying, microwave, and grilling cooking, which was ordered in the following sequence as microwave cooking < grilling < frying. The consumption of Denis fish from different sources (wild and cultured) has no negative effects on health, according to a study of health hazards based on indices of carcinogenic and non-carcinogenic. The metal results indicated that different fish sources (wild and cultured) could be acceptable for human consumption. Data hypothesized a positive impact of awareness among the native community.
Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways
Authors: Adongo Donatus Wewura , Benneh Charles Kwaku , Tandoh Augustine , Biney Robert Peter , Kukuia Kennedy Kwami Edem , Mante Priscilla Kolibea , Harley Benjamin Kingsley , Oteng David , Appiah Emmanuel Aduboffour , Anorbor Ernest Cudjoe , Woode Eric 
Published: October 2023

AbstractPseudospondias microcarpa is used in ethnomedicine to manage central nervous system diseases. The hydroethanolic extract (PME) from the leaves of the plant has shown anxiolytic-like properties in mice anxiety models. However, its effects in chronic anxiety models and possible mechanism(s) of action were not studied. Therefore, the current study evaluated the anxiolytic-like mechanisms of PME in zebrafish models of anxiety. The zebrafish light dark test (LDT) and novel tank test (NTT) were employed to assess the anxiolytic-like effects of PME (0.1, 0.3, 1.0 mg mL−1), fluoxetine (3 × 10−5 mg mL−1) and diazepam (1.5 × 10−7 mg mL−1). The chronic unpredictable stress (CUS) test was used to further evaluate the extract’s anxiolytic-like properties. The potential mechanisms of anxiolytic action of the extract was evaluated after pre-treated with flumazenil, granisetron, methysergide, or pizotifen, all at 1 × 10−3 mg mL−1. The extract significantly decreased anxiety behaviours in the NT and LD tests. These observed effects of the extract were however counteracted by flumazenil, granisetron, methysergide and pizotifen pre-treatment. In addition, PME treatment significantly reversed CUS-induced anxiety behaviours in zebrafish. Results show that PME possesses anxiolytic-like effects possibly through interaction with serotonergic and gamma-aminobutyric acid mediated pathways.
Graphical abstract