bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duty ratio drive prediction model of lifetime degradation for organic light emitting diode‐on‐silicon microdisplay
Authors: Mu Tingzhou , Ji Yuan , Gong Shuping , Zhang Yin , Chen Wendong , Ran Feng 
Published: November 2023

AbstractA duty ratio drive prediction (DRDP) model of luminance degradation for organic light emitting diodes (OLED) microdisplay is proposed in this paper. The traditional stretched exponential decay (SED) model is not applicable for OLED driven by duty ratio. The DRDP model introduces the duty ratio as the variables affecting the lifetime of OLED. By fitting the undetermined coefficients with the measured luminance data, the quantitative relationships among the initial luminance, duty ratio, and OLED lifetime are obtained. Meanwhile, the model quantifies the phenomenon of spontaneous luminance recovery, which occurs when OLED switches from bright to dark. Finally, the DRDP model is used to compensate the luminance degradation of OLED driven by duty ratio. The experimental results show that the average prediction accuracy of DRDP model for white, red, green, and blue (W/R/G/B) OLED degradation trend is 0.9623. The average prediction accuracy of W/R/G/B OLED lifetime is 0.6119, which is greater than that of SED model. The lifetime is extended by 89.83% after compensation.
Alveolar ridge reconstruction with a digitally customized bone block allograft
Authors: Bontá Hernán , Bugiolachi Juliana , Perrote Carla A. , Sánchez Luciana M. , Pulitano Manisagian Gisela E. , Galli Federico G. , Caride Facundo 
Published: November 2023

AbstractBackgroundReduced alveolar ridge volume is an often consequence after tooth loss, compromising implant placement and prosthetic rehabilitation. The digital customization of bone block allografts (BBA) is an alternative that incorporates advantages such as intimate contact with the recipient bed, increasing graft stability and reduced surgical time. In addition, enamel matrix derivate (EMD) has attracted interest for its effect on osteogenic gene expression and cell adhesion; few studies have focused on the benefits of bone regeneration with EMD. The aim of this case report is to present the reconstruction of a severely atrophic alveolar ridge defect with a digitally customized bone block allograft (CBBA) in combination with EMD as an adjuvant for bone regeneration and soft tissue healing.MethodsInitially, the digital planning and manufacture of the BBA was performed based on an initial cone beam computed tomography (CBCT) scan. EMD was applied to the recipient site and to the CBBA before graft fixation. After 6 months, bone biopsies were obtained on re‐entry surgery for prosthetically guided implant placement.ResultsClinically, bone block showed good integration with the adjacent tissue and no signs of rejection or necrosis were found. On the histological evaluation, new bone was observed in intimate contact with the allograft and showed viable osteocytes and osteoblasts along its entire length. Residual allograft particles were observed to be highly osteoconductive.ConclusionAccording to the clinical and histological results presented, the digital customization of the BBA allows an ideal graft fit to the recipient bed with excellent results in bone regeneration.
Reconciling the personalization–privacy paradox via DoctorBots: The roles of service robot acceptance model elements and technology anxiety
Authors: Shi Yichuan , Lu Wei , Zhou Yuwei 
Published: November 2023

AbstractThe role of artificial intelligence (AI)‐based DoctorBots in improving healthcare and the medical industry is expected to increase significantly in the coming decades. However, contrary to the general view that AI can gradually replace human work, user acceptance of DoctorBots has become an obstacle to the development of AI medical diagnosis. Building on the service robot acceptance model (sRAM), this study investigates the potential of the functional, socioemotional, and relational elements of DoctorBots to reconcile the personalization–privacy paradox, thus enhancing user acceptance. Via two scenario‐based experiments with 398 participants, this study reveals that the negative influence of the personalization–privacy paradox on user acceptance is exacerbated when users' technology anxiety is high. In addition, an online survey of 400 DoctorBot users indicates that ease of use, subjective social norms, social presence, and rapport are effective in addressing both nonpersonalization (NPC) and privacy concerns (PVC). These findings suggest that the healthcare industry can leverage DoctorBots to implement self‐diagnosis. Specifically, DoctorBots' functional elements are effective in mitigating users' NPC, and their relational elements are effective in extenuating users' PVC.
Antimicrobial Activity of Depsidones and Macrocyclic Peptides Isolated from Marine Sponge‐Derived Fungus Aspergillus nidulans M256
Authors: Thi Hoang Anh Nguyen , Mai Anh Nguyen , Thi Thu Huyen Vu , Thi Dao Phi , Thi Mai Huong Doan , Van Cuong Pham , Thanh Xuan Dam , Huu Tai Bui , Thi Hong Minh Le , Van Kiem Phan 
Published: November 2023

AbstractChemical study on marine sponge‐derivated fungus Aspergillus nidulans resulted in the isolation of seven depsidones (1–7) and two macrocyclic peptides (8 and 9). Their chemical structures were elucidated by extensive analyses of HRESIMS and NMR spectral data, as well as comparison with the literature. Compound 1 was an undescribed depsidone. All compounds exhibited significant antimicrobial activity (MICs: 2–128 μg/mL) towards at least one of seven microbial strains, including Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, and Candida albicans. Of these, chlorinated depsidones (1–3, and 5) displayed potential antimicrobial activity. Nidulin (2) possessed good activity against tested strains except for S. enterica with MIC values in range of 2–16 μg/mL. Interestingly, undescribed depsidone 1 was selectively bioactive on the Gram‐positive bacteria (MICs: 2–4 μg/mL) and yeast (MIC: 8 μg/mL) but inactivity on the Gram‐negative bacteria (MICs: >256 μg/mL). Macrocyclic peptides, 8 and 9, displayed modest activity against E. faecalis strain with MIC values of 32 and 128 μg/mL, respectively.
A New Look at the Mechanism of Cocrystal Formation and Coformers Exchange in Processes Forced by Mechanical and/or Thermal Stimuli –ex situandin situStudies of Low‐Melting Eutectic Mixtures
Authors: Dudek Marta K. , Trzeciak Katarzyna , Tajber Lidia , Zając Justyna , Kaźmierski Sławomir , Pindelska Edyta , Makowski Tomasz , Svyntkivska Mariia , Potrzebowski Marek J. 
Published: November 2023

AbstractThree different devices: ball mill, hot stage melting, and magic angle spinning (MAS) NMR rotor were used for the preparation of ethenzamide (ET) cocrystals with glutaric acid (GLU), ethylmalonic acid (EMA) and maleic acid (MAL) as coformers. In each case, well‐defined binary systems (ET:EMA, ET:GLU, ET:MAL) were obtained. The common features of the two solvent free methods of cocrystal formation (grinding, melting) are presented on the basis of arguments obtained by solid state NMR spectroscopy. Thermal analysis (Differential Scanning Calorimetry) proved that the eutectic phase arises over a wide range of molar ratios of components for each of the binary systems. NMR techniques, supported by theoretical calculations, allowed to provide details about the pathway of the reaction mechanism with atomic accuracy. It was found that the formation of ET cocrystals is a complex process that requires five steps. Each step has been recognized and described. Variable temperature 1D and 2D MAS NMR experiments allowed to track physicochemical processes taking place in a molten state. Moreover, it was found that in a multicomponent mixture consisting of all four components, ET, EMA, GLU, and MAL, ET in the molten phase behaves as a specific selector choosing only one partner to form binary cocrystals according to energy preferences. The process of exchange of coformers in binary systems during grinding, melting, and NMR measurements is described. The stabilization energies (Estab) and molecular electrostatic potential (MEP) maps computed for the cocrystals under discussion and their individual components rationalize the selection rules and explain the relationships between individual species.
A Metal‐Free and Operationally Simple Radical Trifluoromethylative Borylation of Unactivated Alkenes
Authors: Keerthika K. , Muhammed S Bazil , Geetharani K. 
Published: November 2023

AbstractWe herein describe a protocol to synthesize trifluoromethylated alkyl boronates from alkenes by the mutual activation of the Togni II and the bis(catecholato)diboron reagents in the absence of any catalyst and additives. This reaction enables synthesizing a series of trifluoromethylated alkyl boronates using unactivated alkenes, including natural products and drug derivatives, in a regioselective manner. Moreover, the synthetic utility of the boronic ester present in the product allows access to a range of trifluoromethyl containing compounds. The radical trapping and gas detection experiments reveal that the more Lewis acidic diboron reagent determines the rapid formation of trifluoromethyl and boron centered radicals.
Regioisomers of Aromatic Thioethers with Aggregation‐Induced Phosphorescence
Authors: Schmiedtchen Marco , Maisuls Iván , Wölper Christoph , Strassert Cristian A. , Voskuhl Jens 
Published: November 2023

AbstractIn this contribution, we describe a library of nine different molecular asterisks, all based on aromatic thioethers. Here, the substitution patterns of the central core unit bearing two nitriles and the rotors featuring methoxy groups were permuted. In addition, the photophysical properties in the solid and aggregated state were investigated. X‐ray diffractometry confirmed the molecular structures. In this frame, the molecular packing in the crystal lattice of the two polymorphs of mNoM was extensively studied and a correlation between photoluminescence and secondary interactions was evaluated. In the solid state, all compounds showed emission in the yellow to red part of the electromagnetic spectrum (555–644 nm) with lifetimes of up to 25 μs and photoluminescence quantum yields of up to 47 %, depending on the substitution pattern. As all the evaluated compounds perform as good emitters with aggregation‐induced phosphorescence (AIP), these compounds can be regarded as multivalent platforms for future applications in supramolecular assemblies or as biomedical labels due to the versatile substitution patterns, manifold geometries as well as appealing photophysical properties.
Community‐Based Organizations as Trusted Messengers in Health
Authors: Chau Michelle M. , Ahmed Naheed , Pillai Shaaranya , Telzak Rebecca , Fraser Marilyn , Islam Nadia S. 
Published: November 2023

AbstractTrust is a key component in delivering quality and respectful care within health care systems. However, a growing lack of confidence in health care, particularly among specific subgroups of the population in the United States, could further widen health disparities. In this essay, we explore one approach to building trust and reaching diverse communities to promote health: engaging community‐based organizations (CBOs) as trusted community messengers. We present case studies of partnerships in health promotion, community education, and outreach that showcase how CBOs’ programs build and leverage trust in health care systems through their workforce, services, and engagement with the community.
Awareness of cancer among adolescents: A study of nine focus groups in Aotearoa New Zealand
Authors: Marsh Louise , McNoe Bronwen , Venter Noeleen , Quigg Robin , Notoa Faith , Reeder Anthony I. 
Published: November 2023

AbstractIssue AddressedOne third of cancers are potentially preventable by modifying key risk factors that arise during adolescence. To help inform prevention efforts, we investigated adolescents' understanding of cancer risk factors, symptoms and signs and barriers to help‐seeking.MethodsNine focus groups were conducted with purposefully sampled, binary‐gendered friendship groups of 12 to 17‐year‐olds. Interviews were analysed using a qualitative descriptive method based on the topic schedule, transcripts and field notes.ResultsBehavioural, genetic and environmental factors were commonly explored as risk factors. Most cancer symptoms identified focused on physical indicators, such as lumps and skin appearance. Facilitators and barriers to good health choices involved both external and internal factors: education, affordability, attitudes and the social environment. Most participants indicated they would talk to trusted friends and family members about health issues, but only when the condition became ‘serious’. The most common source of health information was the internet.ConclusionsAdolescents have a good understanding of behavioural risk factors, but poor knowledge of some key cancer symptoms. A support system was recognised to be a substantive factor in dealing with health issues, as were youth‐focused health services. Understanding of the preventability of many cancers was not widespread with participants.So What?The results emphasise a requirement for appropriate, affordable and accessible youth‐focused health services. There is a need for age‐ and culturally appropriate interventions that improve knowledge of cancer symptoms. Immunisation against the viruses implicated in cervical cancer is one example of a clinical cancer prevention intervention in adolescence.
Policy interplay among social health insurance system, pension system, delayed retirement initiative and implications for the self‐rated health status of older workers
Authors: Li Jiannan , Yuan Bocong , Li Kunmei , He Longtao 
Published: November 2023

AbstractDelayed retirement initiative proposed in China attaches greater importance to the sustainability of pension systems and the labour shortage, but less to the health status of older people. The existing social health insurance and pension system are not well established to match this initiative. This study investigates the policy mix of delayed retirement, employment‐based social health insurance, social pension participation for health status of older people. Results of the data from the China Health and Retirement Longitudinal Study (CHARLS‐2018) show that late retirement could benefit health status among older adults. Moreover, such effect of late retirement appears more salient for those uninsured by employment‐based social health insurance and those still in the pension contribution phase upon reaching the statutory retirement age. Hence, in countries with inadequate health insurance and pension systems, such as China, delayed retirement may serve as an important alternative to social security for the health of older people.
Cervical cancer in Mozambique: Clinical characteristics, treatment and survival of incident cases admitted to the Oncology Service of Maputo Central Hospital in 2016‐2018
Authors: Tulsidás Satish , Fontes Filipa , Monteiro Kátia , Mussa Muhammad , Lovane Lucília , Morais Alberto Gudo , Brandão Mariana , Lunet Nuno , Carrilho Carla 
Published: November 2023

AbstractIn Mozambique, cervical cancer is the most frequent cancer in women. However, studies about cervical cancer treatment and prognosis are scarce. We describe the clinical characteristics, treatment and survival of patients with cervical cancer admitted to Maputo Central Hospital (MCH) in 2016 to 2018. Sociodemographic, clinical and cancer‐related data were retrieved from clinical records of patients admitted to the Oncology Service of the MCH with an incident cervical cancer in 2016 to 2018 (n = 407). The Pathology Service database was used to obtain information regarding pathological diagnosis. Survival data was obtained through the MCH Cancer Registry and clinical records. Odds ratios for the association between patients' characteristics and the diagnosis of advanced stage cancer were computed using logistic regression. Survival analyses were performed using the Kaplan‐Meier estimator. A total of 91.2% of the patients were diagnosed with advanced disease (stage IIB‐IV) and squamous cell carcinoma was the predominant histological subtype. Most of the patients underwent chemotherapy (93.1%) but <7% were submitted to surgery, radiotherapy or brachytherapy. Those living with HIV had 3.4‐fold higher odds of advanced disease. Overall survival was 72.7% (95% confidence interval [CI]: 67.9‐77.0) at 1‐year and 51.0% (95%CI: 45.3‐56.3) at 2‐years. Those with early stage (IA‐IIA) and asymptomatic at diagnosis had a significantly higher 2‐year overall survival. In Mozambique, cervical cancer is diagnosed mostly in advanced stages, resulting in poor prognosis. This highlights the importance of HPV vaccination and screening, to decrease the burden of cervical cancer in this context.
Medical students' self‐perceived knowledge and clinical comfort with genetics in Pakistan
Authors: Arshad Maheen , Trepanier Angela , Hashmi S. Shahrukh , Naeem Rizwan , Mehmood Saqib , Ashfaq Myla 
Published: November 2023

AbstractPakistan has a high rate of genetic disorders and neonatal mortality concurrent with noted lack of genetic counselors and geneticists. To meet the needs of the patient population, the responsibility of providing clinical genetic services falls on general and specialty physicians. However, their education regarding these essential services is not standardized in medical school curricula nor has it ever been evaluated. The purpose of this work is to describe the self‐perceived knowledge, clinical comfort, and perspectives of Pakistani medical students toward their medical genetics' education. A web‐based survey was distributed electronically to medical schools around the country. The survey comprised of four sections: (1) participant demographics, (2) self‐perceived medical genetics knowledge, (3) level of comfort in applying genetic knowledge and skills, and (4) attitudes toward medical genetics education. Descriptive statistics and a one‐way analysis of variance were used for data analysis. Medical students in years 3, 4, and 5 (n = 473) from 25 medical schools participated in this research representing medical education in four Pakistani provinces. Most medical students reported “minimal” to “basic” knowledge of genetic testing methodology (64.7%), cancer genetics (64.9%), prenatal genetic testing (63.02%), and treatment strategies for genetic disease (72.9%). A plurality of students (37%) reported they were uncomfortable with interpreting and communicating genetic test results to patients. Medical students also expressed dissatisfaction with their medical genetics (40%) and genetic counselors training (42%). The self‐perceived knowledge and clinical comfort with genetics among Pakistani medical students was limited, especially regarding genetic testing. A significant portion (74.5%) expressed desire for additional genetics education during medical school to aid in their role as future physicians. It is important for physicians‐in‐training to have a solid understanding of genetic concepts, technologies, and genetic counseling to best support their patients. As endorsed by the participating medical students, this study supports inclusion of more robust genetics' education into Pakistan's medical school curricula.
Overexpression of VEGFA mediated by HIF‐1 is associated with higher rate of spread through air spaces in resected lung adenocarcinomas
Authors: Guo Liang , Li Shaoling , Wang Xing , Zhu Yuming , Li Juanjuan 
Published: November 2023

AbstractBackgroundSpread through air spaces (STAS), a newly identified pattern of invasion in lung adenocarcinomas (LACs), is an unfavorable prognostic factor for patients with LAC, but the molecular characteristics and mechanisms underlying STAS have not been adequately explored.MethodsIn total, 650 pathologically confirmed invasive LAC patients who underwent curative resection between December 2019 and April 2020 were reviewed. Disease‐free survival (DFS) and overall survival (OS) were analyzed using the log‐rank test and the Cox proportional hazards model. A comparative deep sequencing analysis was conducted to explore the molecular characteristics underlying STAS. Vascular endothelial growth factor A (VEGFA) expression was evaluated by immunoblotting and immunohistochemical analysis using fresh tumor tissue and tissue microarray.ResultsSTAS was more prevalent in patients with a smoking history (p < 0.001), high pathological TNM stage (p < 0.001), lymphovascular invasion (p < 0.001), visceral pleural invasion (p < 0.001) and micropapillary/solid histological subtypes (p < 0.001). STAS‐negative patients had better DFS (p < 0.001) and OS (p = 0.003) compared to STAS‐positive patients with invasive LACs, especially in the lymph node‐negative population (p < 0.001). After RNA‐sequencing analysis, hypoxia‐inducible factor‐1 (HIF‐1) signaling was enriched and appeared to be strongly correlated with STAS, and more STAS‐positive individuals were detected in the higher VEGFA‐expressing group (p = 0.042).ConclusionsWe demonstrated that STAS was an independent prognostic marker of poor clinical outcome, especially in lymph node‐negative patients, and that higher VEGFA expression mediated by HIF‐1 signaling was associated with an increased STAS rate.
Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry database
Authors: Yokoshiki Hisashi , Shimizu Akihiko , Mitsuhashi Takeshi , Ishibashi Kohei , Kabutoya Tomoyuki , Yoshiga Yasuhiro , Kondo Yusuke , Abe Haruhiko , Shimizu Wataru ,   Members of the Implantable Cardioverter‐Defibrillator (ICD) Committee of the Japanese Heart Rhythm Society
Published: November 2023

AbstractBackgroundTemporal change in outcomes of heart failure patients receiving cardiac resynchronization therapy with a defibrillator (CRT‐D) is unknown.MethodsWe assess outcomes and underlying heart diseases of patients receiving CRT‐D with analyzing database of the Japan cardiac device treatment registry (JCDTR) at the implantation year 2011–2015 and New JCDTR at the implantation year 2018–2021.ResultsProportion of nonischemic heart diseases was about 70% in both the groups (JCDTR: 69%; New JCDTR: 72%). Cardiac sarcoidosis increased with the rate of 5% in the JCDTR to 9% in the New JCDTR group. During an average follow‐up of 21 months, death from any cause occurred in 167 of 906 patients in the JCDTR group (18%) and 79 of 611 patients in the New JCDTR group (13%) (adjusted hazard ratio [aHR] in the New JCDTR group, 0.72; 95% confidence interval [CI]: 0.55–0.94; p = .017). The superiority was mainly driven by reduction in the risk of noncardiac death. With regard to appropriate and inappropriate implantable cardioverter–defibrillator (ICD) therapy, there was a significant reduction in the New JCDTR group versus the JCDTR group (aHR in the New JCDTR group, 0.76; 95% CI: 0.59–0.98; p = .032 for appropriate ICD therapy; aHR in the New JCDTR group, 0.24; 95% CI: 0.12–0.50; p < .0001 for inappropriate ICD therapy).ConclusionsAll‐cause mortality was reduced in CRT‐D patients implanted during 2018–2021 compared to those during 2011–2015, with a significant reduction in noncardiac death.