bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new schedule method for compact propulsion system model
Authors: Bai Yu , Zhu Zhengchen , Xu Zhigui , Guo Haoran 
Published: February 2024

Abstract
The PSC (Performance Seeking Control) based on CPSM (Compact Propulsion System Model) has been verified by NASA. However, the CPSM has poor accuracy at off-design points. Therefore, a new basepoint schedule method is proposed to improve the CPSM accuracy at off-design points. At the off-design point, the thermodynamic parameters which is a function of temperature is an importance factor that influence the accuracy of model based on parameter corrections. Therefore, the temperature of fan inlet is taken into account during scheduling the basepoint vector. The simulations have shown that the accuracy of CPSM is at its best when the engine operates at a point where the temperature of the fan inlet is equal to the one of the basepoint. With the increase or decrease of the temperature of the fan inlet, the modeling errors of CPSM will increase. The simulations also demonstrate that the relative errors of the improved CPSM decrease significantly compared to those of the conventional CPSM at the off-design point.
Maximum Strength and Power as Determinants of Match Skating Performance in Elite Youth Ice Hockey Players
Authors: Keiner Michael , Kierot Martin , Stendahl Mattia , Brauner Torsten , Suchomel Timothy J. 
Published: February 2024

Abstract
Keiner, M, Kierot, M, Stendahl, M, Brauner, T, and Suchomel, TJ. Maximum strength and power as determinants of match skating performance in elite youth ice hockey players. J Strength Cond Res XX(X): 000–000, 2023—Maximum strength has a strong influence on speed-strength performances such as sprints and jumps. Important for sports practice is whether these findings are also reflected in game performance. Therefore, the aim of this study was to explore the influence of maximum strength and power performance on linear on-ice skating performance in testing and during game play. A cross-sectional study was conducted, and 24 highly trained male youth ice hockey players participated. Jump performances (countermovement jump [CMJ], drop jumps), maximum strength (1 repetition maximum [1RM] squat and isometric trap bar pull [ITBP]), and on-ice linear sprints (15 m [LS15], 30 m [LS30], flying 15 m [FLY15]) were measured. Match performances (among others: peak skating speed) were collected of 4 regular league games using a local positioning system. Correlation coefficient and explained variance were calculated (ρ ≤ 0.05). Correlations between maximum strength and jump with on-ice linear sprint performance showed 1–35% explained variance. Correlations between “off ice” test (CMJ, relative 1RM) and game data (peak skating speed) showed 22–30% explained variance, respectively, while ITBP and DJ missed significant level. Between linear sprint and game performance showed 15–59% explained variance. In this study, a clear influence of 1RM in squatting and CMJ performance on on-ice linear sprint as well as in-game peak skating speed was observed. These findings show that strength and jumping performance can be valuable tests within a comprehensive test battery and indicate the relevance of strength and jumping tasks within the regular exercise program to improve in-game skating performance.
Alcohol availability and affordability in three constituent entities of the Russian Federation
Authors: Kontsevaya A. V. , Antsiferova A. A. , Mukaneeva D. K. , Kudryavtsev A. V. , Kutsenko V. A. , Filichkina E. M. , Pustelenin N. A. , Khudyakov M. B. , Glukhovskaya S. V. , Solovyova A. V. , Drapkina O. M. 
Published: February 2024

Aim. To analyze availability and affordability of alcoholic beverages in Russian cities.Material and methods. We assessed the actual state of urban infrastructure in the Arkhangelsk, Tver and Sverdlovsk regions. Data were collected in three districts of Arkhangelsk, three districts of Tver, three districts of Yekaterinburg and Revda, where participants of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation-3 (ESSE-RF3) study (2021) lived. The study objects were elements of the city infrastructure where alcoholic beverages were sold. To assess the infrastructure, special software was developed to collect and analyze the necessary data using Open Street Maps. Data were collected from January to March 2022.Results. In total, 1180 alcohol-selling outlets were identified in the study areas: in Arkhangelsk — 450, in Yekaterinburg and Revda — 444, and in Tver — 286. Mainly alcoholic beverages in Sverdlovsk and Tver regions can be purchased in the alcohol section of a grocery store (n=260, 58,6% and n=185, 41,4%, respectively), and in the Arkhangelsk region — in a specialized liquor stores (n=263, 58,4%). The median number of alcohol stores located within a radius of 1000 m from the place of residence of the ESSE-RF3 participant was 33, and within a radius of 400 meters — 8. In Arkhangelsk, the alcohol was sold in a grocery store located in the same building as the college branch. In the Sverdlovsk region, the nearest alcohol store was located at a distance of 50 m from the kindergarten, in the Tver region — 44 m from the college. A 0,5 liter bottle of vodka was sold below the price floor in 55,1% of specialized liquor stores in the Sverdlovsk region and in 66,8% of such liquor stores in the Tver region.Conclusion. As a result of the study, availability and affordability of alcoholic beverages in Arkhangelsk, Tver, Yekaterinburg and Revda was assessed. The findings reflect the high availability of alcohol and indicate the need for interventions at both the national and local government levels. The used method of collecting and analyzing data demonstrated sufficient research effectiveness and can be recommended for wider use.
Socio-demographic characteristics and behavioral risk factors of the Vladimir region population
Authors: Mamedov M. N. , Sushkova L. T. , Isakov R. V. , Kutsenko V. A. , Drapkina O. M. 
Published: February 2024

Aim. To analyze socio-demographic characteristics and the prevalence of behavioral risk factors in the adult population of the Vladimir region, taking into account sex characteristics.Material and methods. This cross-sectional population-based study was organized in 5 cities of the Vladimir region (Vladimir, Kovrov, Murom, Yuryev-Polsky and Vyazniki) from May 2018 to March 2020. The study included 1350 men and women aged 30-69 years. The response rate was 87%. A total of 1174 people completed the study, of whom 424 (36.1%) were men and 750 (63.9%) were women. A total of 1174 people completed the study. Of these, 424 (36,1%) were men and 750 (63,9%) women. Respondents were surveyed using a standard questionnaire prepared by the National Medical Research Center for Therapy and Preventive Medicine, which included socio-demographic characteristics, behavioral risk factors, data on somatic diseases and medications taken.Results. Smoking prevalence among men was 38,4%, which was 4 times higher than in women (p=0,001). Walking <30 min/day, as a sign of a sedentary lifestyle, was detected in 41,3% of men, and among women in every third (33,2%, p=0,007). Every second man and woman during the survey reported insufficient consumption of vegetables and fruits. Adding salt to food was detected in 34,4% of men and 21,7% of women (p=0,001). Alcohol abuse rate among men was 12,5, while among women it was 2 times lower and amounted to 5,6% (p=0,001). The variability of these disorders was noted in different Vladimir region cities.Conclusion. In the analyzed random sample of adults from the Vladimir region, every second man and woman does not consume enough vegetables and fruits, while every third person leads a sedentary lifestyle. At the same time, there are 4 times more male smokers and 2 times more male alcohol abusers than females.
Role of biomarkers of collagen metabolism and systemic inflammation in myocardial remodeling in patients with stable chronic coronary artery disease and obstructive sleep apnea
Authors: Osipova O. A. , Gosteva E. V. , Petrichko T. A. , Ponomarenko T. N. , Bukatov V. V. , Shepel R. N. , Vasilyeva L. V. , Kryshka A. A. , Serdyukova A. V. , Brizhaneva A. S. 
Published: February 2024

Aim. To study the relationship of biomarkers of collagen metabolism and systemic inflammation with left ventricular (LV) remodeling in patients with stable coronary artery disease (CAD) and obstructive sleep apnea (OSA).Material and methods. The study included 195 patients with stable CAD, of which 63 without OSA and 132 patients with combination of CAD and OSA. The mean age of patients was 63,4±3,7 years. Biomarkers of collagen metabolism and systemic inflammation were assessed by determining the concentration of matrix metalloproteinase (MMP)-9, tissue inhibitor of matrix metalloproteinase-1, monocyte chemoattractant protein-1 (MCP-1) and calculating the neutrophil-to-lymphocyte (NLR) and platelet-tolymphocyte ratio (PLR). Echocardiography was performed according to a standard protocol.Results. There were no significant differences in systemic inflammation parameters (MCP-1, NLR, PLR) between the group of patients with CAD and CAD with mild OSA and a significantly higher level of MCP-1, NLR, PLR in more severe OSA. In patients with CAD and severe OSA, the eccentric LV remodeling was diagnosed in 75% of individuals, while the concentric type was diagnosed in only 25%.Conclusion. In patients with stable CAD, the more severe the OSA, the more pronounced systemic inflammation (MCP-1, NLR, PLR), and there are higher proportion of eccentric LV hypertrophy, which may be associated with an imbalance of fibrosis markers (high concentration of MMP-9 with an almost unchanged level of tissue inhibitor of MMP-1).
Validation of genetic risk scores for coronary artery disease, developed on European population samples, in Russian population
Authors: Ershova A. I. , Meshkov A. N. , Kutsenko V. A. , Vyatkin Yu. V. , Kiseleva A. V. , Sotnikova E. A. , Limonova A. S. , Garbuzova E. V. , Muromtseva G. A. , Zaicenoka M. , Zharikova A. A. , Ramensky V. E. , Belova O. А. , Rachkova S. A. , Pokrovskaya M. S. , Shalnova S. A. , Boytsov S. A. , Drapkina O. M. 
Published: February 2024

Aim. To evaluate the information content of genetic risk scores (GRSs) for coronary artery disease (CAD), previously developed on European populations, in representatives of the Russian population.Material and methods. The work involved 1685 people from the ESSE-Ivanovo epidemiological study. CAD was verified in 3,1% of individuals. The coronary composite endpoint was assessed annually during 8-year follow-up. Next generation sequencing was performed using a targeted panel. Logistic regression analysis and area under the ROC curve (AUC) were used. Age, sex, and smoking status were taken into account in the multivariate model.Results. Of the 16 GRSs included in the analysis, only 2 GRSs demonstrated significance in the univariate analysis of association with CAD (highest AUC — 0,577). In a multivariate model, with an increase by 1 standard deviation (SD) for the 6 studied GRSs, a significant association with CAD was obtained — the odds ratio varied in the range of 1,31-1,47. The two GRSs demonstrated significant differences in the incidence of CAD between the groups corresponding to the upper and lower quintiles. Forty-five endpoints were registered. The risk ratio for the end point with an increase in GRS by 1 SD, taking into account cofactors, exceeded statistical significance for the 9 analyzed GRS and was in the range of 1,36-1,54.Conclusion. For the first time in Russia, 16 CAD GRSs, previously developed on European samples, was validated. The results were reproduced only for a few of the studied CAD SGRs.
Traumatic injury of vertebral artery complicated by formation of a giant pseudoaneurysm of the V3 segment (clinical observation and literature review)
Authors: Ayrapetyan A. A. , Gromov D. G. , Papoyan S. A. , Smyalovskiy D. V. , Asaturyan K. S. , Starikov S. S. , Zaytsev A. D. , Tavlueva E. V. 
Published: February 2024

Traumatic vertebral artery injury (TVAI) is a rare but severe pathology which can be associated both with penetrating injury of the neck and blunt or unclassified injury. Injury of the vertebral artery, especially due to gunshot or knife wounds, causes severe condition of the patients, development of a wide spectrum of complications including life-threatening, high rates of disabilities and mortality.There is no consensus on the treatment tactics for this pathology. Open surgery as the first stage of surgical intervention can be used in a limited number of cases. X-ray endovascular techniques of TVAI treatment are considered to be preferable.We present a clinical case of a 27‑year-old patient with TVAI caused by a penetrating gunshot wound of the neck and complicated by formation of a giant pseudoaneurysm of the V3 segment of the vertebral artery. Two-stage combination treatment of TVAI was performed using endovascular and open surgical techniques.Descriptions of TVAI cases are rare, and further accumulation and analysis of corresponding data and proposals on treatment of the patients with TVAI will help to formulate precise algorithms of doctors’ actions and optimize treatment tactics.
Technique for intraoperative monitoring of corticospinal tract integrity using an electrode with a dynamic balloon
Authors: Krylov V. V. , Lukianchikov V. A. , Gorozhanin V. A. , Barbakadze Z. A. , Sinkin M. V. 
Published: February 2024

Aim. To present a technique for continuous monitoring of corticospinal tract integrity using an electrode with a dynamic balloon, examine the advantages and disadvantages of the selected and alternative monitoring techniques.Materials and methods. At the 1st stage, an electrode combined with a dynamic balloon was prepared. At the 2nd stage, continuous monitoring of the corticospinal tract using direct stimulation of the cortex using ballon grid during the main stage of cerebral surgery was performed. At the 3rd stage, interpretation of the obtained neurophysiological responses was performed.Results. The presented technique of continuous monitoring of the integrity of the corticospinal tract through direct cortical stimulation using the developed device prevents false response decreases which significantly helps with the interpretation of the obtained results and increases information value of the technique. The described technique is based on the presented clinical observations of intracerebral tumor resection, as well as microsurgical aneurysm clipping using the technique. During surgery, no false decrease of the neurophysiological signal amplitude was observed due to dynamic ballon inflation and maintenance of close contact between the electrode and the surface of the brain. A surgery performed using this technique allowed to achieve a favorable neurological outcome in a patient in the postoperative period.Conclusion. The presented device allows to perform continuous neuromonitoring using direct cortical electrostimulation with a strip electrode at any level of brain retraction. The technique decreases the risk of primary and secondary injury of the corticospinal and corticobulbar tracts which increases safety of neurosurgical intervention and decreases risks of neurological complications.
NUMERICAL INVESTIGATION OF THE VALVE MODEL FOR PRIMARY SUTURELESS IMPLANTATION
Authors: Klyshnikov Kirill Yu. , Ovcharenko Evgeny A. , Onishchenko Pavel S. , Glushkova Tatyana V. , Kostyunin Alexander E. , Rezvova Maria A. , Barbarash Olga L. 
Published: February 2024

HighlightsThe presented numerical model of the bioprosthesis support frame for sutureless fixation needs to be optimized to reduce the amplitude of the von Mises stresses.The presented setup of numerical modeling has been validated using the study of commercial analogs. AbstractAim. To assess the stress-strain state of three computer models of TAVI prosthesis support frames during crimping and shaping to the delivery configuration.Methods. The study included three models of stent-like support frames for balloon-expandable devices, which are intended to serve as a foundation for the subsequent development of a domestic aortic valve prosthesis: two models of commercial bioprostheses and one experimental. The objects were evaluated numerically under the conditions of stress-strain state that arises in the stent support frames, simulating two loads: crimping and shaping to the delivery configuration. The study was conducted using the numerical modeling complex Abaqus/CAE (“Dassault Systemes”, France). The key indicators for evaluation were the von Mises stress, as a strength criterion, and its distribution over the frame; the presence and proportion of elastic recoil.Results. It was shown that all samples are capable of reaching the required diameter without excessive material. A quantitative investigation of the Von Mises stress showed that commercial models display amplitudes below the material`s strength limit (892.4 and 916.8 MPa), whereas the proprietary model exceeds this limit, reaching 991.4 MPa, requiring geometry optimization. Shaping to the delivery configuration indicates that all models provide safe expansion up to 26 mm, with a Von Mises stress level in the range of 882.4–914.1 MPa, which is below the strength limit of the cobalt-chrome alloy. Moreover, we have noted heterogeneous stress distribution, with concentration in the lamella junction areas.Conclusion. Thus, it has been demonstrated that numerical modeling and the finite element method can be effectively applied to assess the stress-strain state of sutureless prostheses. Geometry optimization and further development of this project – the development of a Russian minimally invasive aortic valve prosthetic system, may contribute towards increasing the accessibility of this treatment method.
FEATURES OF POLYURETHANE MATRIX REMODELING IN SHEEP MODEL EXPERIMENTS
Authors: Antonova Larisa V. , Velikanova Elena A. , Senokosova Evgeniya A. , Mukhamadiyarov Rinat A. , Krivkina Evgeniya O. , Koshelev Vladislav A. , Mironov Andrey V. , Shabaev Amin R. , Sardin Egor S. , Prokudina Ekaterina S. , Khanova Maryam Y. , Barbarash Leonid S. 
Published: February 2024

HighlightsThe article describes the features of remodeling of polyurethane matrices during long-term implantation into the vascular bed of sheep. The results indicate high biocompatibility of polyurethane and resistance to bioresorption. The obtained data are significant for the development of medical products for cardiovascular surgery, in particular, biodegradable vascular prostheses. AbstractAim. To evaluate the features of polyurethane remodeling in a long-term experiment on a large animal model.Methods. Matrices made of 12% polyurethane solution in chloroform were manufactured by electrospinning at the Nanon-01A nanofiber electrospinning system (MIC, Japan). Matrix samples in the form of patches were implanted into the carotid arteries of sheep (n = 3) for a period of 6 months. The patency of vessels with implanted matrices was assessed after 2, 4 and 6 months using a portable hand-carried color Doppler - M7 Premium Ultrasound Machine (Mindray, China). The structure of the matrix surface before and after implantation was studied using an S-3400N scanning electron microscope (Hitachi, Japan). Histological examination of the explanted samples was carried out using an AXIO Imager A1 microscope (Carl Zeiss, Oberkochen, Germany) with previous staining of matrix sections with hematoxylin-eosin, Van Gieson and alizarin red C. Data processing was performed using the Statistica 6.0 software.Results. After 2, 4 and 6 months of implantation of polyurethane matrices into the carotid artery of sheep, complete patency of the carotid arteries was revealed. Macroscopically, after 6 months of implantation, the matrix completely resembled the carotid artery wall due to the full consolidation of the matrix with the artery wall and remodeling. Layers of newly formed vascular tissue – neointima and neoadventitia – were formed on the basis of the matrix. Histological examination revealed the structural integrity of the matrix without signs of inflammation and calcification both in the matrix structure and adjacent tissues.Conclusion. The biological inertia of polyurethane matrices with signs of remodeling was noted, which indicates a high biocompatibility of the material. Resistance to bioresorption and the ability to keep the frame of the product for a long time allows us to consider polyurethane as a suitable material for the formation of anti-aneurysmal protection of biodegradable vascular prostheses.
PATHOGENIC MECHANISMS OF HEART FAILURE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Ivanchenko Vera S. , Gagarina Alina A. , Goryanskaya Irina Ya. , Soldatova Olga V. , Ushakov Alexey V. 
Published: February 2024

Highlights The review presents up-to-date data on the contribution of type 2 diabetes mellitus to the development and progression of heart failure. The review highlights the key mechanisms of the pathogenesis of heart failure associated with changes in the energy metabolism of cardiomyocytes. AbstractType 2 diabetes mellitus is one of the main risk factors that significantly worsen the prognosis of heart failure and increases the probability of fatal cardiovascular events. The development of heart failure in diabetic patients involves a great number of risk factors for the rapid progression of atherosclerosis, as well as numerous combinations of neurohumoral, molecular and histological changes not associated with atherogenesis, which interconnection results in cardiovascular complications and heart failure decompensation. This review discusses the key mechanisms underlying development of heart failure in type 2 diabetes mellitus, in particular, special attention is paid to cardiomyocyte energy metabolism, cardiomyocyte death, and the significance of epigenetic factors in progression of chronic heart failure.
BIODEGRADABLE ANTI-ADHESIVE MEMBRANES WITH ANTIBACTERIAL PROPERTIES FOR USE IN SURGERY
Authors: Kudryavtseva Yulia A. , Kanonykina Anastasia .Yu. , Shishkova Daria K. , Efremova Natalia A. , Onishchenko Pavel S. , Barbarash Leonid S. 
Published: February 2024

HighlightsAdhesion formation is a classic complication of any surgical intervention, which reduces the quality of life of patients and carries the risk of fatal complications during repeated surgery. Moreover, there is an issue of postoperative wound infection. Currently, there are no effective anti-adhesive agents with antibacterial activity in the arsenal of surgeons. Aim. To justify and develop biodegradable anti-adhesive membranes with antibacterial activity.Methods. The membranes were made by electrospinning using a composition of biodegradable polymers: polylactide-co-glycolide copolymer (50:50) Mm 20–30 KDa and ε-caprolactonone. The antibiotic Tigacil was added to the polymer solution to impart antibacterial properties to the membrane. The surface structure of the membranes was evaluated using a scanning electron microscope. Physical, mechanical and hemocompatibility properties were studied. The antibacterial activity of the membranes was evaluated after manufacturing, sterilization and storage for 24 months.Results. The inclusion of Tigacil in the membrane composition contributed to a decrease in fiber thickness by almost 4 times, while the packing of fibers became denser, which affected the increase in the strength of the modified membranes. Samples of membranes before and after the inclusion of Tigacil have no negative effect on erythrocytes The obtained results confirm the antibacterial activity of membranes against Staphylococcus aureus and Klebsiella pneumoniae, as well as the preservation of these properties after sterilization and during 2 years of storage.Conclusion. The inclusion of Tigacil in the polymer composition makes it possible to create biodegradable anti-adhesive membranes with antibacterial activity, which is maintained for two years after the manufacture. The inclusion of Tigacil in the polymer fiber composition does not adversely affect the initial properties of the membrane.