bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arginine‐Enhanced Antimicrobial Activity of Nanozymes against Gram‐Negative Bacteria
Authors: Zhao Zihan , Wen Shu'an , Song Ningning , Wang Lixiang , Zhou Yuan , Deng Xue , Wu Changbu , Zhang Guili , Chen Jun , Tian Guo‐Bao , Liang Minmin , Zhong Lan‐Lan 
Published: November 2023

AbstractThe continuous reduction of clinically available antibiotics has made it imperative to exploit more effective antimicrobial therapies, especially for difficult‐to‐treat Gram‐negative pathogens. Herein, it is shown that the combination of an antimicrobial nanozyme with the clinically compatible basic amino acid L‐arginine affords a potent treatment for infections with Gram‐negative pathogens. In particular, the antimicrobial activity of the antimicrobial nanozyme is dramatically increased by ≈1000‐fold after L‐arginine stimulation. Specifically, the combination therapy enhances bacterial outer and inner membrane permeability and promotes intracellular reactive oxygen species (ROS) generation. Moreover, the metabolomic and transcriptomic results reveal that combination treatment leads to the increased ROS‐mediated damage by inhibiting the tricarboxylic acid cycle and oxidative phosphorylation, thereby inducing an imbalance of the antioxidant and oxidant systems. Importantly, L‐arginine dramatically significantly accelerates the healing of infected wounds in mouse models of multidrug‐resistant peritonitis‐sepsis and skin wound infection. Overall, this work demonstrates a novel synergistic antibacterial strategy by combining the antimicrobial nanozymes with L‐arginine, which substantively facilitates the nanozyme‐mediated killing of pathogens by promoting ROS production.
Photosynthetic and Self‐Draining Biohybrid Dressing for Accelerating Healing of Diabetic Wound
Authors: Ren Xinyu , Hou Zhiming , Pang Bo , Gao Cen , Tang Rongbing 
Published: November 2023

AbstractWound healing is a well‐orchestrated progress associated with angiogenesis, epithelialization, inflammatory status, and infection control, whereas these processes are seriously disturbed in diabetic wounds. In this study, a biohybrid dressing integrating the inherent ability of Bromeliad leaf (photosynthesis and self‐draining) with the therapeutic effect of artificial materials (glucose‐degrading and ROS‐scavenging) is presented. The dressing consists of double‐layered structures as follows: 1) Outer layer, a Bromeliad leaf substrate full of alginate hydrogel‐immobilized glucose oxidase (GOx@Alg@Bromeliad substrate, abbreviated as BGA), can generate oxygen to guarantee the GOx‐catalyzed glucose oxidation by photosynthesis, reducing local hyperglycemia to stabilize hypoxia inducible factor‐1 alpha (HIF‐1α) for angiogenesis and producing hydrogen peroxide for killing bacteria on the surface of wound tissue. The sophisticated structure of the leaf drains excessive exudate away via transpiration‐mimicking, preventing skin maceration and impeding bacterial growth. 2) Inner layer, microneedles containing catalase (CAT‐HA MNs, abbreviated as CHM), reduces excessive oxidative stress in the tissue to promote the proliferation of fibroblasts and inhibits proinflammatory polarization of macrophages, improving re‐epithelialization of diabetic wounds. Together, the biohybrid dressing (BGA‐CHM, abbreviated as BCHM) can enhance angiogenesis, strengthen re‐epithelialization, alleviate chronic inflammation, and suppress bacterial infection, providing a promising strategy for diabetic wound therapy.
Soft and Flexible Bioelectronic Micro‐Systems for Electronically Controlled Drug Delivery
Authors: Mariello Massimo , Eş Ismail , Proctor Christopher M. 
Published: November 2023

AbstractThe concept of targeted and controlled drug delivery, which directs treatment to precise anatomical sites, offers benefits such as fewer side effects, reduced toxicity, optimized dosages, and quicker responses. However, challenges remain to engineer dependable systems and materials that can modulate host tissue interactions and overcome biological barriers. To stay aligned with advancements in healthcare and precision medicine, novel approaches and materials are imperative to improve effectiveness, biocompatibility, and tissue compliance. Electronically controlled drug delivery (ECDD) has recently emerged as a promising approach to calibrated drug delivery with spatial and temporal precision. This article covers recent breakthroughs in soft, flexible, and adaptable bioelectronic micro‐systems designed for ECDD. It overviews the most widely reported operational modes, materials engineering strategies, electronic interfaces, and characterization techniques associated with ECDD systems. Further, it delves into the pivotal applications of ECDD in wearable, ingestible, and implantable medical devices. Finally, the discourse extends to future prospects and challenges for ECDD.
Intelligent Size‐Switchable Iron Carbide‐Based Nanocapsules with Cascade Delivery Capacity for Hyperthermia‐Enhanced Deep Tumor Ferroptosis
Authors: Wang Jingjing , Fang Zhi , Zhao Chenyang , Sun Zhaoli , Gao Shen , Zhang Biao , Qiu Daping , Yang Meng , Sheng Fugeng , Gao Song , Hou Yanglong 
Published: November 2023

AbstractThe ferroptosis pathway is recognized as an essential strategy for tumor treatment. However, killing tumor cells in deep tumor regions with ferroptosis agents is still challenging because of distinct size requirements for intratumoral accumulation and deep tumor penetration. Herein, intelligent nanocapsules with size‐switchable capability that responds to acid/hyperthermia stimulation to achieve deep tumor ferroptosis are developed. These nanocapsules are constructed using poly(lactic‐co‐glycolic) acid and Pluronic F127 as carrier materials, with Au–Fe2C Janus nanoparticles serving as photothermal and ferroptosis agents, and sorafenib (SRF) as the ferroptosis enhancer. The PFP@Au–Fe2C–SRF nanocapsules, designed with an appropriate size, exhibit superior intratumoral accumulation compared to free Au–Fe2C nanoparticles, as evidenced by photoacoustic and magnetic resonance imaging. These nanocapsules can degrade within the acidic tumor microenvironment when subjected to laser irradiation, releasing free Au–Fe2C nanoparticles. This enables them to penetrate deep into tumor regions and disrupt intracellular redox balance. Under the guidance of imaging, these PFP@Au–Fe2C–SRF nanocapsules effectively inhibit tumor growth when exposed to laser irradiation, capitalizing on the synergistic photothermal and ferroptosis effects. This study presents an intelligent formulation based on iron carbide for achieving deep tumor ferroptosis through size‐switchable cascade delivery, thereby advancing the comprehension of ferroptosis in the context of tumor theranostics.
Gradient Quasi‐Solid Electrolyte Enables Selective and Fast Ion Transport for Robust Aqueous Zinc‐Ion Batteries
Authors: Cui Yanglansen , Chen Weipeng , Xin Weiwen , Ling Haoyang , Hu Yuhao , Zhang Zhehua , He Xiaofeng , Zhao Yong , Kong Xiang‐Yu , Wen Liping , Jiang Lei 
Published: November 2023

AbstractThe quasi‐solid electrolytes (QSEs) attract extensive attention due to their improved ion transport properties and high stability, which is synergistically based on tunable functional groups and confined solvent molecules among the polymetric networks. However, the trade‐off effect between the polymer content and ionic conductivity exists in QSEs, limiting their rate performance. In this work, the epitaxial polymerization strategy is used to build the gradient hydrogel networks (GHNs) covalently fixed on zinc anode. Then, it is revealed that the asymmetric distribution of negative charges benefits GHNs with fast and selective ionic transport properties, realizing a higher Zn2+ transference number of 0.65 than that (0.52) for homogeneous hydrogel networks (HHNs) with the same polymer content. Meanwhile, the high‐density networks formed at Zn/GHNs interface can efficiently immobilize free water molecules and homogenize the Zn2+ flux, greatly inhibiting the water‐involved parasitic reactions and dendrite growth. Thus, the GHNs enable dendrite‐free stripping/plating over 1000 h at 8 mA cm−2 and 1 mAh cm−2 in a Zn||Zn symmetric cell, as well as the evidently prolonged cycles in various full cells. This work will shed light on asymmetric engineering of ion transport channels in advanced quasi‐solid battery systems to achieve high energy and safety.
Does adolescent depression modify the association between psychosocial job stressors and mental health in emergent adulthood?
Authors: LaMontagne Anthony D. , Too Lay‐San , Witt Katrina , Evans‐Whipp Tracy , Owen Patrick J. , Toumbourou John W. 
Published: November 2023

AbstractBackgroundJob stressors can be particularly harmful to the mental health of disadvantaged groups through differential exposure, differential sensitivity to the effects of exposure, or both. In this paper, we assess the extent to which emergent adult workers with an adolescent history of high depression symptoms may be differentially sensitive to the effect of job stressors on mental health.MethodsWe conducted a secondary analysis of three waves of the Australian arm of the International Youth Development Study (n = 1262). We used multivariable linear regression to assess whether self‐reported measures of high depression symptoms at one or two time points in adolescence (ages 11–16 years) modified the cross‐sectional association between four self‐reported job stressors (job demands, job control, job strain, and incivility at work) and psychological distress (Kessler‐10 scores) in emergent adulthood (ages 23–27 years).ResultsFor all four job stressors, there was a consistent pattern of approximately a doubling in the magnitude of association for participants with a history of high depression symptoms at two points in adolescence compared with those with no history of depression. However, results of effect modification analysisfor only job demands and job strain excluded chance as a potential explanation.ConclusionsFindings showed partial support for the hypothesis that a history of high depression symptoms in adolescence predicts stronger associations between job stressor exposures and psychological distress among those employed in emergent adulthood. The limitations of this secondary analysis suggest a need for purpose‐designed studies to answer this important research question more definitively.
Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer
Authors: Rinaldi Francesco , Schipani Fabrizio , Balboni Beatrice , Catalano Federico , Marotta Roberto , Myers Samuel H. , Previtali Viola , Veronesi Marina , Scietti Luigi , Cecatiello Valentina , Pasqualato Sebastiano , Ortega Jose Antonio , Girotto Stefania , Cavalli Andrea 
Published: November 2023

AbstractDNA repair protein RAD51 is a key player in the homologous recombination pathway. Upon DNA damage, RAD51 is transported into the nucleus by BRCA2, where it can repair DNA double‐strand breaks. Due to the structural complexity and dynamics, researchers have not yet clarified the mechanistic details of every step of RAD51 recruitment and DNA repair. RAD51 possesses an intrinsic tendency to form oligomeric structures, which make it challenging to conduct biochemical and biophysical investigations. Here, for the first time, we report on the isolation and characterization of a human monomeric RAD51 recombinant form, obtained through a double mutation, which preserves the protein's integrity and functionality. We investigated different buffers to identify the most suitable condition needed to definitively stabilize the monomer. The monomer of human RAD51 provides the community with a unique biological tool for investigating RAD51‐mediated homologous recombination, and paves the way for more reliable structural, mechanistic, and drug discovery studies.
Colloidal and Thermal Stability of Three‐Component Hybrid Materials Containing Clay Mineral, Polysaccharide and Surfactant
Authors: Godek Ewelina , Maciołek Urszula , Kosińska‐Pezda Małgorzata , Byczyński Łukasz , Nowicka Aldona , Grządka Elżbieta 
Published: November 2023

AbstractThe paper presents the colloidal and thermal stability of the three‐component hybrid materials containing halloysite, polysaccharides (alginic acid, cationic cellulose and hydroxyethyl cellulose) and Tritons. TX‐100, TX‐165 and TX‐405 were used as non‐ionic surfactants. Stability and other properties of the hybrid materials were tested by the following methods: UV–Vis, TGA (thermogravimetric analysis) and DSC (differential scanning calorimetry), CHN (elemental analysis), SEM‐EDX (scanning electron microscopy with energy dispersive X‐ray spectroscopy) and tensiometry. According to the results with the increasing polymer concentration the colloidal stability of the tested systems also increases. Moreover, the addition of the surfactants causes the increase of polysaccharide adsorption but the colloidal stability of the tested systems decreases due to large weights of formed aggregates. As follows from the thermal analysis, the comparison of the TG/DTG‐DSC curves obtained for the investigated polymers confirms that their thermal decomposition courses have some common features. The obtained results have the application potential in the formation of the materials for the pollutants removal from water and sewages.
Endoscopic diagnosis and prevalence of early gastric cancer in India: A prospective study
Authors: Mohapatra Ashutosh , Mohapatra Sonmoon , Mahawar Shruti , Pani Krushna Chandra , Mohapatra Nachiketa , Ramchandani Mohan , Reddy Nageshwar , Goenka Mahesh K. , Uedo Noriya 
Published: November 2023

AbstractObjectivesAlthough countries like Japan and South Korea have implemented nationwide endoscopic screening programs, there is limited evidence on the effectiveness of endoscopy for diagnosing early gastric cancer (EGC) in developing countries such as India. In the present study, we aimed to determine the feasibility of endoscopic detection of EGC from India.MethodsThe data was prospectively collected for all patients ≥40 years who underwent a diagnostic upper endoscopy from April to September 2021. A single endoscopist who performed the endoscopic procedures completed 1‐month training in advanced endoscopy in Japan. Following the training, the endoscopist continued to engage in internet‐based discussions regarding his cases encountered. Prior to this training, the endoscopist had not detected any EGC cases during his 12‐year gastroenterology practice.ResultsA total of 1033 patients were included in the study, with males accounting for 65.4% and a mean age 52 years. The average procedural time was 7.13 ± 4.8 min. A total of 25 patients (2.4%) were found to have GC, including 6 patients (0.6%) with EGC. Two patients had synchronous EGC lesions. All EGC patients were males, with an average age of 66 years. All EGCs were detected in the distal stomach in the presence ofHelicobacter pyloriinfection and severe atrophic gastritis.ConclusionOur findings showed that the endoscopic detection of EGC is feasible in India. Optimal training on endoscopic diagnosis of EGC can improve the detection of such lesion. Further studies are warranted to assess the optimization and implementation of an endoscopic screening program for EGC in India.
Photoisomerization of Alkenes via Energy Transfer Enabled by Cu‐Acetylide Complexes
Authors: Murakami Ryo , Kojima Noritaka , Kamo Ryoya , Tanishima Hiroto , Inagaki Fuyuhiko 
Published: November 2023

AbstractThis work demonstrates the isomerization of alkenes enabled by copper‐acetylide complexes under blue light. This system is applicable to the E→Z isomerization of α‐ and β‐substituted cinnamate derivatives with moderate to excellent Z/E ratios. A reaction pathway involving singlet energy transfer (EnT) from the copper‐acetylide complex to the alkene is proposed.
Cancer mortality after kidney transplantation: A multicenter cohort study in Italy
Authors: Taborelli Martina , Serraino Diego , Cimaglia Claudia , Furian Lucrezia , Biancone Luigi , Busnach Ghil , Bossini Nicola , Citterio Franco , Veroux Massimiliano , Iaria Maurizio , Argiolas Davide , Todeschini Paola , Manzia Tommaso Maria , Pisani Francesco , Cantaluppi Vincenzo , Simone Simona , Mangino Margherita , Campise Mariarosaria , Ambrosini Andrea , Caputo Flavia , Piselli Pierluca ,   the Italian Transplant and Cancer Cohort Study
Published: November 2023

AbstractKidney transplant (KT) recipients are known to be at risk of developing several cancer types; however, cancer mortality in this population is underinvestigated. Our study aimed to assess the risk of cancer death among Italian KT recipients compared to the corresponding general population. A cohort study was conducted among 7373 individuals who underwent KT between 2003 and 2020 in 17 Italian centers. Date and cause of death were retrieved until 31 December 2020. Indirect standardization was used to estimate standardized mortality ratios (SMRs) and corresponding 95% confidence intervals (CIs). Cancer was the most common cause of death among the 7373 KT recipients, constituting 32.4% of all deaths. A 1.8‐fold excess mortality (95% CI: 1.59‐2.09) was observed for all cancers combined. Lymphomas (SMR = 6.17, 95% CI: 3.81‐9.25), kidney cancer (SMR = 5.44, 95% CI: 2.97‐8.88) and skin melanoma (SMR = 3.19, 95% CI: 1.03‐6.98) showed the highest excess death risks. In addition, SMRs were increased about 1.6 to 3.0 times for cancers of lung, breast, bladder and other hematopoietic and lymphoid tissues. As compared to the general population, relative cancer mortality risk remained significantly elevated in all age groups though it decreased with increasing age. A linear temporal increase in SMR over time was documented for all cancers combined (P < .01). Our study documented significantly higher risks of cancer death in KT recipients than in the corresponding general population. Such results support further investigation into the prevention and early detection of cancer in KT recipients.
An m1A/m6A/m5C‐associated long non‐coding RNA signature: Prognostic and immunotherapeutic insights into cervical cancer
Authors: Pan Chenxiang , Lin Jiali , Dai Xiaoxiao , Jiao Lili , Liu Jinsha , Lin Aidi 
Published: November 2023

AbstractBackgroundCervical cancer (CC) remains a significant clinical challenge, even though its fatality rate has been declining in recent years. Particularly in developing countries, the prognosis for CC patients continues to be suboptimal despite numerous therapeutic advances.MethodsUsing The Cancer Genome Atlas database, we extracted CC‐related data. From this, 52 methylation‐related genes (MRGs) were identified, leading to the selection of a 10 long non‐coding RNA (lncRNA) signature co‐expressed with these MRGs. R programming was employed to filter out the methylation‐associated lncRNAs. Through univariate, least absolute shrinkage and selection operator (i.e. LASSO) and multivariate Cox regression analysis, an MRG‐associated lncRNA model was constructed. The established risk model was further assessed via the Kaplan–Meier method, principal component analysis, functional enrichment annotation and a nomogram. Furthermore, we explored the potential of this model with respect to guiding immune therapeutic interventions and predicting drug sensitivities.ResultsThe derived 10‐lncRNA signature, linked with MRGs, emerged as an independent prognostic factor. Segmenting patients based on their immunotherapy responses allowed for enhanced differentiation between patient subsets. Lastly, we highlighted potential compounds for distinguishing CC subtypes.ConclusionsThe risk model, associated with MRG‐linked lncRNA, holds promise in forecasting clinical outcomes and gauging the efficacy of immunotherapies for CC patients.
Effect of process parameters on the mechanical behavior of additively manufactured and FSW joined PLA wood sheets
Authors: Koçar Oğuz , Anaç Nergizhan , Palaniappan Sathish Kumar , Doğan Merve , Siengchin Suchart 
Published: November 2023

AbstractFriction stir welding (FSW), a solid‐state joining method, is an innovative technique widely employed in the welding of thermoplastics, with broad application areas such as the automotive and aerospace industries. Due to its inherent advantages, including ease of processing, biodegradability, and printability, polylactic acid (PLA) and its derivatives are notably the most commonly used polymers in 3D printing. The limited print area of 3D printers necessitates post‐production joining processes. In this study, the weldability of plates obtained using PLA Wood filament through the FSW is evaluated. For this purpose, different pin geometries (triangle, square, and screw), feed rates (20, 40, and 60 mm/min), and tool rotation speeds (1250, 1750, and 2250 rpm) are employed. Visual inspections are conducted to determine the effects of process parameters on weld quality and to identify defects in the weld region. Temperature values are measured to investigate the influence of heat generated during the FSW process. Furthermore, after determining the highest weld strengths achieved for each pin geometry, the weldability of PLA Wood material with PLA‐CF and PLA Plus materials is investigated using these parameters. The results indicate that the highest weld quality for joining PLA Wood plates is achieved using the square pin geometry, 20 mm/min feed rate, and 1750 rpm with an efficiency of 74.5%. When welding PLA Wood with PLA‐CF and PLA Plus, high weld strengths are obtained using the same process parameters (square pin, 20 mm/min, and 1750 rpm).Highlights
Friction stir welding process of 3D printed PLA Wood material.
Friction stir welding process of dissimilar materials pairs.
Effect of welding parameters on weld strength and hardness.
Identifying the fracture surface images occurring in parts after friction stir welding.
Examination of temperature generation during friction stir welding.
Examination of cognitive appraisals, irrational beliefs, and challenge and threat evaluations in the prediction of tournament affective states and performance of competitive elite Indian golfers
Authors: Chadha Nanaki J. , Turner Martin J. , Slater Matthew J. 
Published: November 2023

AbstractResearchers have intimated that cognitions and emotions can change in the lead up to important events. However, previous research has adopted atemporal cross‐sectional designs, making it challenging to understand how cognitions and emotions unfold in the lead up to a competition. In the current study, we extended previous research by examining the temporal patterns of cognitive appraisals, irrational beliefs, and challenge and threat evaluations in predicting pre‐competitive affective states (hedonic balance and anxiety) in the lead up to an actual competition, among competitive elite Indian golfers (N = 107). We adopted a within‐subjects repeated‐measures design and collected data in the lead up to an actual golf tournament, at three timepoints; 1 week before (T1), the night before (T2), and an hour prior (T3). Self‐reported measures of cognitive appraisals, irrational beliefs, challenge and threat evaluations, affect, and anxiety were completed. Also, objective golf performance was collected from participants. Crossed‐lagged path analysis did not find a causal effect for irrational beliefs on any of the variables across the three time points. On the other hand, hierarchical multiple regression analysis determined that changes in irrational beliefs predicted changes in cognitive appraisals, threat evaluation, cognitive and somatic anxiety, and the directional interpretation of anxiety. The findings of temporal patterns in the current research indicated that sport psychologists should consider the dynamic nature of antecedent cognitions and affective states in the lead up to competition, and accordingly provide adequate support to the athletes. Further, limitations and future research is discussed with reference to the results.