bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Smartphone Sensors for Ataxia Trials: Consensus Guidance by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
Authors: Németh Andrea H. , Antoniades Chrystalina A. , Dukart Juergen , Minnerop Martina , Rentz Clara , Schuman Bart-Jan , van de Warrenburg Bart , Willemse Ilse , Bertini Enrico , Gupta Anoopum S. , de Mello Monteiro Carlos Bandeira , Almoajil Hajar , Quinn Lori , Perlman Susan B. , Horak Fay , Ilg Winfried , Traschütz Andreas , Vogel Adam P. , Dawes Helen ,   on behalf of the AGI Digital-Motor Biomarkers Working Group
Published: November 2023

AbstractSmartphone sensors are used increasingly in the assessment of ataxias. To date, there is no specific consensus guidance regarding a priority set of smartphone sensor measurements, or standard assessment criteria that are appropriate for clinical trials. As part of the Ataxia Global Initiative Digital-Motor Biomarkers Working Group (AGI WG4), aimed at evaluating key ataxia clinical domains (gait/posture, upper limb, speech and oculomotor assessments), we provide consensus guidance for use of internal smartphone sensors to assess key domains. Guidance was developed by means of a literature review and a two stage Delphi study conducted by an Expert panel, which surveyed members of AGI WG4, representing clinical, research, industry and patient-led experts, and consensus meetings by the Expert panel to agree on standard criteria and map current literature to these criteria. Seven publications were identified that investigated ataxias using internal smartphone sensors. The Delphi 1 survey ascertained current practice, and systems in use or under development. Wide variations in smartphones sensor use for assessing ataxia were identified. The Delphi 2 survey identified seven measures that were strongly endorsed as priorities in assessing 3/4 domains, namely gait/posture, upper limb, and speech performance. The Expert panel recommended 15 standard criteria to be fulfilled in studies. Evaluation of current literature revealed that none of the studies met all criteria, with most being early-phase validation studies. Our guidance highlights the importance of consensus, identifies priority measures and standard criteria, and will encourage further research into the use of internal smartphone sensors to measure ataxia digital-motor biomarkers.
Pesticide-free arable cropping systems: performances, learnings, and technical lock-ins from a French long-term field trial
Authors: Colnenne-David Caroline , Jeuffroy Marie-Hélène , Grandeau Gilles , Doré Thierry 
Published: November 2023

AbstractTo ensure regular and high yields, current agriculture is based on intensive use of pesticides and fertilizers, which are detrimental to the environment and human health. Moreover, as pest resistance to pesticides increases, and more and more pesticides are taken off the market, national and European policies are becoming powerful drivers to deliver pesticide-free farming systems. Whereas numerous studies have compared organic versus conventional systems, our study assessed, for the first time, the performances of a pesticide-free arable cropping system (No-Pesticide), using synthetic fertilizers, specifically designed to produce high yields and meet environmental goals. This system was compared with an input-based cropping system designed with the same environmental targets (PHEP: productive with high environmental performances) in an 11-year field trial in France (Paris Basin). Banning pesticides did not result in a significant average yield gap (in GJ.ha−1.year−1 or in kg N.ha−1.year−1) calculated over the crop sequence. Yet, some crops’ yields significantly decreased, due either to pest damages, or to limited nitrogen nutrition. In the No-Pesticide system, the mycotoxin content of cereal grains was lower than the regulatory threshold, and the average wheat protein content was higher than the required standard for baking. Indirect energy consumption, total greenhouse gas emissions, number of technical operations, nitrogen fertilizer amounts, and treatment frequency indexes were significantly lower compared to the PHEP system. Conversely, results showed significantly higher direct energy consumption, direct greenhouse gas emissions, and number of work hours for weed control. We identify highly effective agricultural strategies to avoid pesticide use (e.g., widely diverse and long crop sequence; introduction of hemp) and pinpoint several technical lock-ins hampering steady production in pesticide-free systems. We argue that more experiments should be undertaken to deliver technical knowledge for managing major or orphan species within pesticide-free systems, and to provide supplementary results, including economic and social performances.
Static in bone implants: standard steady-state torque and primary stability in a bioactive kinetic screw
Authors: Andreucci Carlos Aurelio , Fonseca Elza M. M. , Jorge Renato N. 
Published: November 2023

AbstractEstablishing a standard measurement for drilling and screwing bone implants in different amounts and qualities of bone tissue, in a simple and adequate way to control and predict results, is the gold standard for successful primary stability and better results on long-term osseointegration. So far, the maximum insertion torque (MIT) has been used as the main parameter to achieve success in primary stability and osseointegration, although it has shown conflicting results in the literature for over four decades when predicting standard or minimum values. Basically, the surgeon's experience guides the planning and execution of the surgical procedure, adapted in each case according to his tactile experience, guided by X-ray analysis and the bone and general conditions of the patient. In this work, using a new biomechanical simple machine as a dental implant, a new method will be described mathematically and experimentally, which standardizes the compression and torque in the implant-bone contact, in five different bone densities, during the achievement of mechanical primary stability. The results described the relationship between the MIT, maximum removal torque, and maximum force of static friction between implant-bone and bone-to-bone, achieving a controlled and predictable standard steady-state torque that maintains equilibrium in elastic stress for the primary stability of bone implants, hereby established for an innovative simple machine Bioactive Kinetic Screw.
Rate-dependent constitutive modelling blasting crack initiation and propagation in rock masses
Authors: Zhang Yongjun , Xu Meng , Liu Sijia , Liu Fei , Wang Qingsong 
Published: November 2023

AbstractThis study examines the fracture mechanism of cracks and the final blasting effects on defective rock masses under blasting loads. The failure processes of jointed rock with two prefabricated joints are investigated through numerical simulations using a two-dimensional finite element method. Subsequently, simulations are performed to analyze the blasting of granite specimens with various joint arrangements, focusing on the influence of front joint length, inclination angle, and blast hole distance on failure patterns, displacement, velocity, and stress at the joint ends. The numerical results provide a comprehensive summary of various typical failure modes near blast holes and joints for the first time. Specifically, the simulation successfully captures the characteristics of the ring crack zone, wing cracks, and main crack deflection affected by the front joint. Moreover, the results highlight the shielding effect of the front joint, which enhances damage in the medium between the borehole and the joint while exhibiting the opposite effect behind the joint in terms of stress wave propagation. Overall, this study offers objective insights into the mechanics and failure characteristics of jointed rock masses under blasting loads and serves as a valuable reference for the design and optimization of blasting operations.
The RNA-binding domain of DCL3 is required for long-distance RNAi signaling
Authors: Li Jie , Zhang Bo-Sen , Wu Hua-Wei , Liu Cheng-Lan , Guo Hui-Shan , Zhao Jian-Hua 
Published: November 2023

AbstractSmall RNA (sRNA)-mediated RNA silencing (also known as RNA interference, or RNAi) is a conserved mechanism in eukaryotes that includes RNA degradation, DNA methylation, heterochromatin formation and protein translation repression. In plants, sRNAs can move either cell-to-cell or systemically, thereby acting as mobile silencing signals to trigger noncell autonomous silencing. However, whether and what proteins are also involved in noncell autonomous silencing have not been elucidated. In this study, we utilized a previously reported inducible RNAi plant, PDSi, which can induce systemic silencing of the endogenous PDS gene, and we demonstrated that DCL3 is involved in systemic PDS silencing through its RNA binding activity. We confirmed that the C-terminus of DCL3, including the predicted RNA-binding domain, is capable of binding short RNAs. Mutations affecting RNA binding, but not processing activity, reduced systemic PDS silencing, indicating that DCL3 binding to RNAs is required for the induction of systemic silencing. Cucumber mosaic virus infection assays showed that the RNA-binding activity of DCL3 is required for antiviral RNAi in systemically noninoculated leaves. Our findings demonstrate that DCL3 acts as a signaling agent involved in noncell autonomous silencing and an antiviral effect in addition to its previously known function in the generation of 24-nucleotide sRNAs.
Perception for Humanoid Robots
Authors: Roychoudhury Arindam , Khorshidi Shahram , Agrawal Subham , Bennewitz Maren 
Published: November 2023

AbstractPurpose of ReviewThe field of humanoid robotics, perception plays a fundamental role in enabling robots to interact seamlessly with humans and their surroundings, leading to improved safety, efficiency, and user experience. This scientific study investigates various perception modalities and techniques employed in humanoid robots, including visual, auditory, and tactile sensing by exploring recent state-of-the-art approaches for perceiving and understanding the internal state, the environment, objects, and human activities.Recent FindingsInternal state estimation makes extensive use of Bayesian filtering methods and optimization techniques based on maximum a-posteriori formulation by utilizing proprioceptive sensing. In the area of external environment understanding, with an emphasis on robustness and adaptability to dynamic, unforeseen environmental changes, the new slew of research discussed in this study have focused largely on multi-sensor fusion and machine learning in contrast to the use of hand-crafted, rule-based systems. Human robot interaction methods have established the importance of contextual information representation and memory for understanding human intentions.SummaryThis review summarizes the recent developments and trends in the field of perception in humanoid robots. Three main areas of application are identified, namely, internal state estimation, external environment estimation, and human robot interaction. The applications of diverse sensor modalities in each of these areas are considered and recent significant works are discussed.
Current Emerging Green Technologies for the Valorization of Grape and Cherry Wastes
Authors: Voss Monica , Gaudino Emanuela Calcio , Tabasso Silvia , Forte Claudio , Cravotto Giancarlo 
Published: November 2023

AbstractThis review aims to highlight current emerging technologies for the valorization of the bioactive fraction of waste from cherry and grape processing industries through its recovery and conversion into high added-value products. Due to its richness in diverse functional and health-related metabolites, the valorization of cherry residue and grape residue as a source of bioactive compounds for new food, nutraceutical, and pharmaceutical products has great interest and potential. Furthermore, aiming for more sustainable processes, several process intensification technologies (UAE, SWE, MAE, PEF, ASE, and NaDES) have emerged in recent decades to extract bioactive compounds from these byproducts, according to a circular economy approach. These techniques allow a considerable reduction in extraction time, greater mass transfer, lower energy consumption, volume of solvents, and energy. Consequently, these new technologies have potential for application on a pilot scale.
Food choices for weight loss: what dietary strategies would people use?
Authors: Giacone Luana , Siegrist Michael , Hartmann Christina 
Published: November 2023

AbstractPrevious observational research showed that one of the most common strategies used to lose weight is to avoid or restrict the consumption of specific food items. However, the question of how people behave and implement strategies in actual decision-making situations involving food choices for weight loss purposes remains inconclusive. This experimental study using a food buffet aimed to examine people’s different dietary strategies and motives for selecting foods for an entire day for weight loss purposes compared with a normal-day (ND) food selection. A total of 111 participants (55 % women) had to choose foods for both a ND and a weight loss day (WLD) (within-study design). Kilocalories and nutrients were calculated based on the weights of the foods selected, and food choice motives were assessed using a questionnaire. The results showed that for weight loss purposes, the participants selected more vegetables (both sexes) and unsweetened beverages (only men) while reducing their choices of high-fat and high-energy products (both sexes). Participants’ food choices in both conditions (ND and WLD) differed from the official nutrition recommendations. They chose less carbohydrates and fibres and more fat and sugar than recommended. Health, kilocalories and nutrient content (carbohydrates, sugar, fat and protein) were more important food choice motives for weight loss purposes than for a ND food selection, while taste became less important. In conclusion, the participants appeared to be well capable of implementing several appropriate dietary strategies. Further research is needed to explore strategies to help them maintain these dietary changes over the long term.
Co-Operative Citizens? Development, Work and Protest in Guyana, c. 1970–1985
Authors: Curless Gareth 
Published: November 2023

AbstractHistories of Third Worldism have received renewed attention from historians in the past decade. Much of the resulting scholarship has focused on the international to the exclusion of the national. This article addresses this relative neglect by focusing on a particular iteration of Third World nation-state-building: co-operative socialism in Forbes Burnham's Guyana. Refuting the argument that co-operative socialism was imitative and implemented for reasons of political expediency only, the article contends that Burnham's doctrine should be regarded as a meaningful attempt at remaking Guyana's society and economy through its core principles of self-sufficiency, self-reliance, and self-discipline. These principles gave rise to a specific conception of citizenship in 1970s Guyana, where the People's National Congress (PNC) sought to link political belonging and participation with a moral ethic premised on the notion of hard work in service of the nation. The article examines how this collectivist understanding of citizenship gave rise to a particular set of struggles at the turn of the 1980s, as the co-operative republic began to collapse. What emerged from these struggles was an alternate but parallel imagining of citizenship espoused by the Working People's Alliance (WPA), which rejected the PNC's vanguardism in favour of empowering the Guyanese people through the creation of non-hierarchical systems of collective authority. The article concludes by arguing that the failure of the WPA's attempt to overthrow the PNC through popular revolt signified the ends of decolonization and Third Worldism in the Caribbean, and the beginnings of new struggles against new forms of coloniality in the guise of the emerging neoliberal and good governance agendas.
Unpacking L2 explicit linguistic knowledge and online processing of the English modals may and can: A comparison of acceptability judgments and self-paced reading
Authors: Mifka-Profozic Nadia , O’Reilly David , Lovrovic Leonarda 
Published: November 2023

AbstractThe present study uses self-paced reading as a measure of online processing and an acceptability judgement task as a measure of offline explicit linguistic knowledge, to understand L2 learners’ comprehension processes and their awareness of subtle differences between the modal auxiliaries may and can. Participants were two groups of university students: 42 native speakers of English and 41 native speakers of Croatian majoring in L2 English. The study is part of a larger project that has provided empirical evidence of the two modals, may and can, being mutually exclusive when denoting ability (can) and epistemic possibility (may) but equally acceptable in pragmatic choices expressing permission. The present results revealed that L1 and L2 speakers rated the acceptability of sentences in offline tasks similarly; however, L2 learners showed no sensitivity to verb–context mismatches in epistemic modality while demonstrating sensitivity when processing modals expressing ability. Implications for L2 acquisition of modals and future research are discussed.
The NEONATE score predicts freedom from interstage mortality or transplant in a modern cohort
Authors: Ahmed Humera , Anderson Jeffrey B. , Bates Katherine E. , Lannon Carole M. , Brown David W. ,   for the National Pediatric Cardiology Quality Improvement Collaborative
Published: November 2023

AbstractBackground:Derived from the National Pediatric Cardiology Quality Improvement Collaborative registry, the NEONATE risk score predicted freedom from interstage mortality or heart transplant for patients with single ventricle CHD and aortic arch hypoplasia discharged home following Stage 1 palliation.Objectives:We sought to validate the score in an external, modern cohort.Methods:This was a retrospective cohort analysis of single ventricle CHD and aortic arch hypoplasia patients enrolled in the National Pediatric Cardiology Quality Improvement Collaborative Phase II registry from 2016 to 2020, who were discharged home after Stage 1 palliation. Points were allocated per the NEONATE score (Norwood type—Norwood/Blalock–Taussig shunt: 3, Hybrid: 12; extracorporeal membrane oxygenation post-op: 9, Opiates at discharge: 6, No Digoxin at discharge: 9, Arch Obstruction on discharge echo: 9, Tricuspid regurgitation ≥ moderate on discharge echo: 12; Extra oxygen plus ≥ moderate tricuspid regurgitation: 28). The composite primary endpoint was interstage mortality or heart transplant.Results:In total, 1026 patients met inclusion criteria; 61 (6%) met the primary outcome. Interstage mortality occurred in 44 (4.3%) patients at a median of 129 (IQR 62,195) days, and 17 (1.7%) were referred for heart transplant at a 167 (114,199) days of life. The median NEONATE score was 0(0,9) in those who survived to Stage 2 palliation compared to 9(0,15) in those who experienced interstage mortality or heart transplant (p < 0.001). Applying a NEONATE score cut-off of 17 points that separated patients into low- and high-risk groups in the learning cohort provided 91% specificity, negative predictive value of 95%, and overall accuracy of 87% (85.4–89.5%).Conclusion:In a modern cohort of patients with single ventricle CHD and aortic arch hypoplasia, the NEONATE score remains useful at discharge post-Stage 1 palliation to predict freedom from interstage mortality or heart transplant.
Outcomes after initial heart failure consultation in Fontan patients
Authors: Chen Sharon , Shezad Muhammad F. , Lorts Angela , McCormick Amanda D. , Mao Chad Y. , Simpson Kathleen E. , O’Connor Matthew J. , Barnes Aliessa , Lubert Adam M. , Castleberry Chesney , Schmidt Julie , Schroeder Katie , Joong Anna , Bearl David W. , Lal Ashwin K. , Mokshagundam Deepa , Conway Jennifer , Cedars Ari , Schumacher Kurt R. 
Published: November 2023

AbstractBackground:Patients with Fontan failure are high-risk candidates for heart transplantation and other advanced therapies. Understanding the outcomes following initial heart failure consultation can help define appropriate timing of referral for advanced heart failure care.Methods:This is a survey study of heart failure providers seeing any Fontan patient for initial heart failure care. Part 1 of the survey captured data on clinical characteristics at the time of heart failure consultation, and Part 2, completed 30 days later, captured outcomes (death, transplant evaluation outcome, and other interventions). Patients were classified as “too late” (death or declined for transplant due to being too sick) and/or “care escalation” (ventricular assist device implanted, inotrope initiated, and/or listed for transplant), within 30 days. “Late referral” was defined as those referred too late and/or had care escalation.Results:Between 7/2020 and 7/2022, 77 Fontan patients (52% inpatient) had an initial heart failure consultation. Ten per cent were referred too late (6 were too sick for heart transplantation with one subsequent death, and two others died without heart transplantation evaluation, within 30 days), and 36% had care escalation (21 listed ± 5 ventricular assist device implanted ± 6 inotrope initiated). Overall, 42% were late referrals. Heart failure consultation < 1 year after Fontan surgery was strongly associated with late referral (OR 6.2, 95% CI 1.8–21.5, p=0.004).Conclusions:Over 40% of Fontan patients seen for an initial heart failure consultation were late referrals, with 10% dying or being declined for transplant within a month of consultation. Earlier referral, particularly for those with heart failure soon after Fontan surgery, should be encouraged.
HIGHER MOMENT FORMULAE AND LIMITING DISTRIBUTIONS OF LATTICE POINTS
Authors: Alam Mahbub , Ghosh Anish , Han Jiyoung 
Published: November 2023

AbstractWe establish higher moment formulae for Siegel transforms on the space of affine unimodular lattices as well as on certain congruence quotients of
$\mathrm {SL}_d({\mathbb {R}})$
. As applications, we prove functional central limit theorems for lattice point counting for affine and congruence lattices using the method of moments.