bluuebunny/crossref_metadata_2025_split huggingface dataset:
EKSPLIKASI KIRKPATRICK LEVEL 1 DAN 2 PADA PELATIHAN JARAK JAUH DI BALAI DIKLAT KEAGAMAAN BANDUNG
Authors: Nabilah Syifa , Juniarahman Nur Azizah , Purnomo Purnomo 
Published: December 2023

The objective of this study is to conduct an evaluative analysis of the Religious Harmony Distance Training Batch III using the Kirkpatrick evaluation methodology. The training was conducted by the Bandung Religious Training Center, and the assessment will focus on the reaction and learning levels. The employed research methodology entails a descriptive approach that incorporates quantitative techniques. The study's sample consisted of all individuals who had participated in the third batch of the training program. Data for the study was obtained via questionnaires. The findings of this study indicate that the Kirkpatrick level 1 reaction model demonstrated trainees' satisfaction and positive response towards the training implementation. Additionally, at level 2, the learning outcomes effectively met the training objectives. Consequently, the application of the Kirkpatrick model at the reaction and learning levels successfully addressed issues in the third batch, yielding positive outcomes. Keywords: Evaluation; Religious Harmony Training; Kirkpatrick Model
TECHNOLOGY MANAGEMENT IN EDUCATION AND TRAINING: A THEORETICAL CONCEPT
Authors: Fauzi Reza , Khusni Khusni Khusni , Zaqiah Qiqi Yuliati 
Published: December 2023

This study attempts to get a general understanding of technology management in training and education. This research employs a qualitative approach with the literature method. The findings indicated that management actions serve as the key support for educational technology to provide outcomes that are consistent with the goals. The successful management of educational technology by human resources within educational institutions is essential to its implementation in educational institutions. If there is a trained workforce in the area of educational technology who can 1) design learning processes and resources, with the scope of work including designing learning systems, message design, learning strategies, and learner characteristics, then educational technology can be developed and used properly; 2) create educational materials and methods, such as the advancement of print technology, audiovisual technology, computer-based technology, and integrated technology; 3) use learning procedures and tools, such as learning media, educational innovation dissemination, and rules and guidelines adoption governing education and training; 4) manage learning resources and processes with project management, and education-training management information systems, etc.; and 5) evaluate problem analysis, benchmark reference measurement, the formative and summative assessment included in the evaluation. Keywords: Management; Educational Technology; Education; Learning; Training
E-SERVICE QUALITY AND E-RECOVERY SERVICE: EFFECTS ON PERCEIVED VALUE AND LOYALTY INTENTION OF DANA APPLICATION USERS
Authors: Gaffar Mohammad Rizal , Fajar Kurnia , Suryana Marceilla , Febrianty Ilma Amilia , Susanto Eko 
Published: December 2023

DANA is one of the electronic-based financial applications that supports non-cash transactions. It has the second-largest total users in Indonesia. However, users have complained about this application's quality of service and recovery. This research aims to determine the mediating effect of perceived value on e-service quality and e-recovery service towards loyalty intention. This research uses a quantitative method with a purposive sampling technique. The sample in this research is 164 respondents. PLS-SEM is used to analyze the model. The results of this research indicate that e-service quality has a direct and significant effect on perceived value. E-recovery service does not have a direct positive and significant effect on perceived value. Furthermore, there is no mediating effect of perceived value on e-service quality and e-recovery service towards loyalty intention. Keywords: e-service quality; e-recovery service; loyalty intention; perceived value
An Analytical Study to Evaluate the Safety of Prayogika Dhumapana in Dinacharya
Authors: Gupta Divya , Agrawal Sarvesh Kumar , Sharma Vaidya Kamalesh Kumar 
Published: December 2023

ABSTRACT

Background:
Cigarette smoking is one of the most widespread types of tobacco use all over the world, causing a huge number of untimely deaths. On contrary to cigarette smoking, dhumapana (herbal smoke inhalation) is one of the very unique routes of drug administration described by the ancient Acharyas.

Aims and Objectives:
The purpose of medicated dhumapana described in Ayurvedic treatises is prevention or management of vata-kapha disorders. Prayogika dhumapana is advised to be practiced regularly for health promotion and protection of our body. The present study was carried out to prepare prayogika dhumavarti (herbal cigarette) and explore the safety of prayogika dhumapana, by analyzing and comparing the chemical composition of its smoke to that of tobacco smoke.

Materials and Method:

Prayogika dhumavarti was prepared as per the classical text, with contents of eladi gana mentioned in Sushruta Samhita. Analytical tests were performed for various parameters, e.g. tar, nicotine, and polynuclear aromatic hydrocarbons for herbal as well as nonherbal cigarette.

Results:
The amount of tar in prayogika dhumavarti (herbal cigarette) was eight times lesser than the tobacco cigarette (nonherbal sample). The amount of carbon monoxide was found to be 4.0 ppm and 9.0 ppm, respectively; the amount of carbon dioxide was found to be 2281 ppm and 2702 ppm, respectively, in herbal and nonherbal samples.

Conclusion:
Hence, on laboratory analysis, prayogika dhumapana was found to be safe on some major parameters.
Extradiagnostic use of dermoscopy: A report of two cases
Authors: Bhat Yasmeen Jabeen , Bashir Yaqzata , Khursheed Uzair 
Published: December 2023

Abstract
Dermoscopy refers to evaluation of the skin surface using surface microscopy. It is mainly used for the diagnosis of skin disorders. We report two cases in which dermoscopy played a role in treatment. Our first case was a 40-year-old female with history of insect bite. We evaluated the patient using a dermoscope and removed the tick with mouth part embedded in dermis using forceps ensuring full removal after procedure. The second case was a 35-year-old female who presented with a non-healing ulcer over lower back, following excision of epidermoid cyst. Dermoscopy showed the presence of a thread which was removed and repeat dermoscopy following extraction ensured its full removal.
Fibroadenoma in axillary breast tissue - Utility of rapid on-site evaluation & report of two cases
Authors: Santosh Tummidi , Patro Manoj K. , Puneeta Nagiredla 
Published: December 2023

ABSTRACT
Fibroadenoma of axillary breast tissue presents as a palpable mass, cyclic pain in the axilla, and with asthetic concerns. Axillary breast tissue can occur anywhere along the primitive embryonic milk lines, extending from the axilla to the groin, and can present unilaterally or bilaterally. The reported incidence of axillary breast tissue is 0.4%–6% in females. We had two cases of fibroadenoma in the axilla that were diagnosed on rapid on-site evaluation and later confirmed by routine cytology stains in young females. We report the cases for their rarity and high degree of clinical suspicion in the young reproductive age group female. We also emphasize the utility of ROSE in cytopathology.
A free fatty acid receptor agonist inducing autophagy in HT-29 cells by downregulating the AKT/mTOR signaling pathway
Authors: Hoveizi Elham , Rafienia Behnoosh , Shahriari Ali 
Published: December 2023

ABSTRACT

Aims:
GW9508, a free fatty acid receptor agonist acts in a G-coupled protein receptor 40 (GPR40)-dependent pathway. Here, we investigated the induction of stress oxidative and autophagy by GW9508 in the human colorectal cancer cell line (HT-29) and the crosstalk between autophagy and apoptotic in HT-29 cells.

Methods:
HT-29 was treated with GW9508 at a concentrations range of 50–500 μM in fibrin gel. Cell viability was investigated using an MTT assay. Induction of autophagy and apoptosis was assessed through Western blotting for associated proteins, acridine orange staining, MDC staining, qRT-PCR, and electron microscopy. Also, we estimated the molecular interactions between GW9805 and some markers through molecular docking.

Results:
GW9508 inhibited HT-29 cell proliferation, induced apoptosis, and resulted in autophagy. The induced autophagy in cells was confirmed by the observation of autophagosomes, the presence of autophagy markers, including beclin-1, LC3, AMPK, and lack expression of mTOR and AKT. Moreover, GW9508 treatment significantly increased the expression of catalase and superoxide dismutase in cells.

Discussion:
Our results indicated that GW9508 could induce autophagy by inhibiting the Akt/mTOR in HT-29. Hence, GW9508 is suggested as a novel anticancer reagent.
Bizarre parosteal osteochondromatous proliferation Nora’s lesion: Case report of two cases with review of the literature
Authors: Hegde Vindhyaprabha , Mallya Varuna , Tomar Reena , Khurana Nita , Maini Lalit 
Published: December 2023

ABSTRACT
Bizarre parosteal osteochondromatous proliferation (BPOP) is also known as Nora’s disease. It is a benign lesion. Even though recent studies showed probable neoplastic etiology, the exact cause is unknown. BPOP commonly involves small bones of hands and feet. This condition is rare and very few cases are reported. In this report, two cases are presented with clinical, radiological, and histopathological findings. The first case was a 38-year-old female presented with 3-year history of mild painful swelling in the left middle finger and the second case was a 28-year-old male with the left leg swelling for 8 years. On radiology, both cases showed surface lesion with uninvolved medullary cavity. Excision specimen of both the lesions subjected for histopathological examination. Microscopically, there was irregular maturation of the bone and cartilage. Cartilage showed purplish-blue color (blue bone) with bizarre chondrocytes. BPOP is a rare benign condition. Awareness of clinical radiological and microscopic findings is needed for correct diagnosis and to differentiate it from other mimicking benign and malignant conditions.
Effect of radiotherapy on phagocytosis percentage and index in patients with oral squamous cell carcinoma
Authors: Shenpaga Priya Immudi Paranjothi , Rajmohan Muthusamy , Prasad Harikrishnan , Sri Chinthu Kenniyan Kumar , Prema Perumal , Mahalakshmi Loganathan , Shanmuganathan Sivanandham 
Published: December 2023

ABSTRACT

Background:
Phagocytosis plays an important role in the fundamental process of immunity and maintains systemic tissue homeostasis. Phagocytosis function is assessed in radiotherapy to signify the prognosis of patient. Therefore, we designed a study to assess and compare the phagocytosis percentage and phagocytic index of the leucocytes in patients with oral cancer before and after radiotherapy.

Materials and Methods:
A total of 60 subjects of both genders, between 50 and 75 years old, were included in the study. The subjects were categorized into three groups: group I: oral squamous cell carcinoma (OSCC) patients before radiotherapy (n = 20), group II: OSCC patients after radiotherapy (n = 20), and group III: control (n = 20). Further, 2-mL blood samples were collected from the patients during the 1st day before radiotherapy and at the end of radiotherapy. The obtained samples were centrifuged, separated leucocytes were incubated with C. albicans, and smears were made to determine the phagocytosis percentage and phagocytic index. The obtained values were tabulated and statistically analyzed. P < 0.05 was considered to be statistically significant.

Results:
Phagocytosis percentage and phagocytic index of OSCC patients before radiotherapy, OSCC patients after radiotherapy, and in the control group and the difference was found to be statistically highly significant (P < 0.01).

Conclusion:
Phagocytosis function can be determined by assessing the phagocytic index and percentage to know the effect of radiotherapy-induced systemic immune suppression and predict the prognosis of OSCC patients after radiotherapy.
Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of cervical cancer among rural population of Maharashtra: Findings from a hospital-based case-control study
Authors: Datkhile Kailas D. , Patil Satish R. , Patil Madhavi N. , Durgawale Pratik P. , Jagdale Nilam J. , Deshmukh Vinit N. , More Ashwini L. , Gudur Rashmi A. , Gudur Anand K. 
Published: December 2023

ABSTRACT

Background:
Last few decades, multiple studies all over the world revealed the association of genetic polymorphism in cytochrome P450 (CYP) genes with risk of developing different type of cancers, but contradictory outcomes were evidenced in case of cervical cancer (CC) risk. Therefore, the discrepancies in earlier reports influenced us to evaluate the association of CYP1A1*2A rs4646903, CYP1B1*3 rs1056836, CYP2C8*2 rs11572103, CYP2C9*2 rs1799853, CYP2C9*3 rs1057910, and CYP2C19*2 rs4244285 polymorphisms and CC susceptibility in the women of rural population of Maharashtra.

Materials and Methods:
In this case-control study, genetic association of the polymorphisms in CYP genes was studied by using polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) method. The study was conducted among 350 clinically confirmed CC patients and 350 healthy volunteers in a population of south-western Maharashtra. The odds ratio (OR) with 95% confidence interval (CI) and P value were evaluated to get the level of association where P ≤ 0.005 was considered as statistically significant.

Results:
After the analysis of single-nucleotide polymorphism (SNPs) of CYP1A1, CYP1B1, CYP2C8, CYP2C9, and CYP2C19, we noticed that CYP1B1*3 rs1056836 (Leu4326Val) polymorphism possessed a significantly elevated risk (OR = 3.28; 95% CI: 2.18–4.94; P < 0.0001), whereas CYP2C19*2 rs4244285 showed significantly lower risk (OR: 0.53, 95% CI: 0.33–0.85 P < 0.009) of CC in the studied rural population.

Conclusion:
The findings from this study supported that rs1056836 SNP of CYP1B1*3 increase CC development, whereas rs4244285 of CYP2C19*2 lowers the CC risk in the studied population.
Evaluation of survival outcomes and prognostic factors of carcinoma anal canal at a tertiary cancer center
Authors: Mishra Himanshu , Mishra Ritusha , Singh Ankita , Mandal Abhijit , Singh Tej B. , Asthana Anupam K. 
Published: December 2023

ABSTRACT

Context:
Concurrent chemoradiotherapy is considered a standard of care for patients with carcinoma anal canal. Being an unusual malignancy, there is limited Indian data regarding survival outcomes and prognostic factors.

Aim:
To evaluate survival outcomes and associated prognostic factors in patients with carcinoma anal canal treated with radical intent.

Methods and Material:
Patients with squamous cell carcinoma of the anal canal, treated with radical intent between 2015 and 2019 were included in the study. Data regarding the baseline characteristics of the patients and treatment outcomes were collected and analyzed. Survival rates were estimated using Kaplan–Meier method. To determine survival difference between the groups, log-rank test was used. Multivariate analyses were performed with Cox proportional hazard models and P value < 0.05 was considered significant.

Results:
Forty-two patients were identified after applying suitable eligibility criteria. The median age was 55 years (range: 26–80 years).The median follow-up duration was 23.5 months (range: 1.9–51.9 months). The 3-year overall survival (OS), disease-free survival (DFS), and locoregional (LRC) were 78.5%, 53.1%, and 66.4%, respectively. On multivariate analysis, inferior DFS was significantly affected by lack of concurrent chemotherapy (CT) (hazard ratio [HR], 11.50; 95% confidence interval [CI], 1.92–68.78; P = 0.007) and radiotherapy (RT) dose of 45 Gy or less (HR, 35.96; 95% CI, 6.32–204.56; P = 0.000).

Conclusion:
For patients of carcinoma anal canal, concurrent CT and RT dose are independent prognostic factors influencing DFS.
Predictors of response in EGFR-mutant metastatic non-small cell lung cancer patients treated with tyrosine kinase inhibitors
Authors: Dogan Izzet , Khanmammadov Nijat , Yıldız Anıl , Ahmed Melin Aydan , Vatansever Sezai , Saip Pinar , Aydiner Adnan 
Published: December 2023

ABSTRACT

Background:
The goal of the study was to evaluate the efficacy of tyrosine kinase inhibitors in patients with epidermal growth factor receptor (EGFR)-mutant metastatic non-small cell cancer and to determine the factors that predict objective response.

Materials and Methods:
In the study, data from metastatic non-small cell lung cancer patients with EGFR mutations treated with tyrosine kinase inhibitors were retrospectively reviewed. Factors predicting objective response were evaluated with logistic regression analysis.

Results:
The study evaluated the data of 105 patients. The most common EGFR mutations detected in patients were exon 19 (56.2%) and exon 21 (23.8%). The median progression-free survival (PFS) associated with EGFR tyrosine kinase inhibitors was 20.1 (95% confidence interval [CI], 13.4–26.7) months. The median overall survival (OS) in the post-metastasis period was found to be 30.8 (95% CI, 20.2–41.4) months. Five- and seven-year OS was determined as 28.7% and 22.9%, respectively. Factors predicting the objective response were analyzed. Presence of drug-related toxicity (P = 0.02), histopathologic type (P = 0.01), metastasis burden (P = 0.03), and EGFR mutation type (P = 0.04) were found to be statistically significant in multivariate analysis.

Conclusions:
In our study, we found that EGFR tyrosine kinase inhibitors are effective and safe. Better response to EGFR inhibitors was observed in the presence of drug-induced toxicity, adenocarcinoma histology, low metastasis burden, and exon 19 mutation.
Biofilm formation and Streptococcus mutans adhesion on different coated and noncoated nickel-titanium archwires: An in vitro study
Authors: Nookala Havisha , Jain Ravindra K , Ganesh P Sankar 
Published: December 2023

Abstract

Aim:
The orthodontic archwires used in routine practice are coated with esthetic coatings to keep up with the aesthetic demand among patients seeking orthodontic treatment, which have been reported to increase the surface roughness (SR) of archwires and lead to an increase in bacterial and plaque accumulation. This in vitro study aims to compare the biofilm formation and bacterial adherence between esthetic coated and noncoated archwires.

Material and Methods:
This experimental in vitro study was conducted using three aesthetic coated and two noncoated nickel-titanium (NiTi) archwires (n = 5/group). The archwires were subjected to artificially cultured Streptococcus mutans broth followed by colony count assessment (CFU) and crystal violet staining assay to determine S. mutans adhesion and biofilm formation. Statistical analysis was performed using the SPSS software for inter-group and intra-group comparisons of CFU and biofilm formation (optical density) with one-way ANOVA with post hoc Tukey’s test and Mann–Whitney’s U test.

Results:
A significant difference in CFU/biofilm was observed at 3% sucrose concentration between the tested archwires (P = 0.029) and epoxy coated (Libral) archwire had higher S. mutans adhesion when compared to its noncoated counterpart (P = 0.035). The biofilm formation however showed no statistical difference between the tested archwires.

Conclusion:
A significant difference was noted in S. mutans adherence (CFU/biofilm) under 3% sucrose condition, with greater S. mutans adherence in epoxy coated archwire. In vivo use of aesthetic coated archwires is at a similar risk of biofilm accumulation as their noncoated counterparts.
Quantification of red complex microorganisms among patients with different surface-modified dental implants: A prospective clinical study
Authors: Rajasekar Arvina , Varghese Sheeja S 
Published: December 2023

Abstract

Aim:
Dental implant surface treatments affect microbial adhesion even though they have a significant impact on osseointegration. This study aimed to quantify and compare the total bacterial load and red complex microorganisms among patients with different surface-modified dental implants.

Materials and Methods:
In this prospective clinical study, 78 patients who had undergone implant placement for missing single posterior tooth in mandible using sandblasted acid-etched and anodized surface dental implants during August 2019–December 2019 were enrolled and were categorized into Group 1 (SLA; n = 27), Group 2 (SLActive; n = 26), and Group 3 (TiUnite; n = 25) based on dental implants’ surface modification. Total bacterial copy count, total red complex copy-count, and copy-count numbers of Treponema denticola, Porphyromonas gingivalis, and Tanneralla forsythia were quantified using real‑time polymerase chain reaction assay. Paired t test, one-way analysis of variance, and Tukey’s honest significant difference post hoc were used for data analysis.

Results:
Total bacterial load, copy-count of P. gingivalis, copy-count of T. forsythia, copy-count of T. denticola, and total red complex load were high in Group 3 as compared to Groups 1 and 2 (P ≤ 0.05). At baseline (P ≤ 0.05) and the 1-year follow-up (P ≤ 0.05), a significant difference was observed between the groups on the pairwise comparison. An intragroup comparison revealed that all three groups had statistically significant differences from the baseline in terms of all the measured variables (P ≤ 0.05).

Conclusion:
Higher total bacterial count and red complex bacterial count were observed around TiUnite followed by SLA and SLActive dental implants.
Evaluation of Temperature Distributions during Ultrasonography
Authors: Ibitoye Ayo Zaccheaus , Irurhe Nicholas Kayode , Bademosi Oluwarantimi , Yakubu Caleb Itopa , Omidiji Olubukola Abeni , Ihekuna Ogechi Augustina 
Published: December 2023

Abstract

Background:
Ultrasound has played a vital role in the medical imaging system for real-time examination. It is considered safe and economical compared to other imaging modalities. Absorption of ultrasound energy by biological tissues can result in heating, especially if the high intensity is used for a long duration.

Aim:
This study aims to evaluate temperature changes in diagnostic ultrasound scanning patients undergoing different ultrasound examinations.

Materials and Methods:
An infrared thermometer was used to measure the temperature in the subjects’ regions of interest. The transducers of frequencies 3.5 and 7.5 MHz were used for the transmission and reception of ultrasound energy to and from the region of scanning. Three hundred and four patients were recruited from different ultrasound examinations. The thermometer was placed at a distance of 5–15 cm to record temperature changes before and during the ultrasound procedure on each of the subjects. The obtained data were statistically analyzed using the Statistical Package for the Social Sciences (SPSS) version 20.

Result:
The average room temperature during the scanning was 22.2°C. The mean temperature before scanning procedures was 32.3°C. The mean maximum and minimum temperatures before and during the scanning of 304 patients recruited for this study were 34.4°C and 31.3°C, respectively. There was also a significant difference between the temperature measured before and during the scanning of the patients (P = 0.01).

Conclusion:
The findings in this study show that temperatures during the diagnostic ultrasound scanning are not above normal human body temperature; therefore, observable thermal effects are unlikely possible.