bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral anticoagulant treatment: friend or foe in cardiovascular disease?
Authors: Schurgers Leon J. , Aebert Hermann , Vermeer Cees , Bültmann Burkhard , Janzen Jan 
Published: July 2004

Abstract
Calcification is a common complication in cardiovascular disease and may affect both arteries and heart valves. Matrix γ-carboxyglutamic acid (Gla) protein (MGP) is a potent inhibitor of vascular calcification, the activity of which is regulated by vitamin K. In animal models, vitamin K antagonists (oral anticoagulants [OACs]) were shown to induce arterial calcification. To investigate whether long-term OAC treatment may induce calcification in humans also, we have measured the grade of aortic valve calcification in patients with and without preoperative OAC treatment. OAC-treated subjects were matched with nontreated ones for age, sex, and disease. Calcifications in patients receiving preoperative OAC treatment were significantly (2-fold) larger than in nontreated patients. These observations suggest that OACs, which are widely used for antithrombotic therapy, may induce cardiovascular calcifications as an adverse side effect.
CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin
Authors: Karamatic Crew Vanja , Burton Nicholas , Kagan Alexander , Green Carole A. , Levene Cyril , Flinter Frances , Brady R. Leo , Daniels Geoff , Anstee David J. 
Published: July 2004

AbstractTetraspanins are thought to facilitate the formation of multiprotein complexes at cell surfaces, but evidence illuminating the biologic importance of this role is sparse. Tetraspanin CD151 forms very stable laminin-binding complexes with integrins α3β1 and α6β1 in kidney and α3β1 and α6β4 in skin. It is encoded by a gene at the same position on chromosome 11p15.5 as the MER2 blood group gene. We show that CD151 expresses the MER2 blood group antigen and is located on erythrocytes. We examined CD151 in 3 MER2-negative patients (2 are sibs) of Indian Jewish origin with end-stage kidney disease. In addition to hereditary nephritis the sibs have sensorineural deafness, pretibial epidermolysis bullosa, and β-thalassemia minor. The 3 patients are homozygous for a single nucleotide insertion (G383) in exon 5 of CD151, causing a frameshift and premature stop signal at codon 140. The resultant truncated protein would lack its integrin-binding domain. We conclude that CD151 is essential for the proper assembly of the glomerular and tubular basement membrane in kidney, has functional significance in the skin, is probably a component of the inner ear, and could play a role in erythropoiesis.
Zeolite SUZ-4 as Selective Dehydration Catalyst for Methanol Conversion to Dimethyl Ether
Authors: Jiang Shan , Hwang Young Kyu , Jhung Sung Hwa , Chang Jong-San , Hwang Jin-Soo , Cai Tianxi , Park Sang-Eon 
Published: July 2004

Abstract
Zeolite SUZ-4 is found to be a very selective and stable catalyst for producing dimethyl ether in methanol dehydration because the formed dimethyl ether is hardly converted to hydrocarbons, different from ZSM-5 zeolite.
Development and Validation of the Medication Regimen Complexity Index
Authors: George Johnson , Phun Yee-Teng , Bailey Michael J , Kong David CM , Stewart Kay 
Published: July 2004

BACKGROUND: Medication regimen attributes, such as the number of drugs, dosage frequency, administration instructions, and the prescribed dosage forms, have been shown to influence patient outcomes. No single tool for quantifying the complexity of general medication regimens has been published in the medical literature. OBJECTIVE: To develop and validate a tool to quantify the complexity of prescribed medication regimens. METHODS: Literature findings and the expertise of the authors were used for developing the tool. Eight pharmacy researchers helped in establishing the tool's face and content validity. The new tool was tested on 134 medication regimens from patients with moderate to severe chronic obstructive pulmonary disease. Six regimens with a spread of scores on the tool were presented to a 5–member expert panel that subjectively ranked these regimens to confirm the tool's criterion-related validity. The relationships between scores on the tool and various independent variables were tested to judge the tool's construct validity. Two raters scored 25 regimens using the tool to test its inter-rater and test—retest reliabilities. RESULTS: A 65–item Medication Regimen Complexity Index (MRCI) was developed. The expert panel had strong agreement (Kendall's W = 0.8; p = 0.001) on their individual rankings of the 6 regimens. The panel's consensus ranking had perfect correlation with the MRCI ranking. The total MRCI score had significant correlation with the number of drugs in the regimen (Spearman's Rho = 0.9; p < 0.0001), but not with the age and gender of the patients. Inter-rater and test—retest reliabilities for the total score and scores for individual sections on the MRCI were ≥0.9. CONCLUSIONS: The MRCI is a reliable and valid tool for quantifying drug regimen complexity with potential applications in both practice and research.
Lack of Pharmacokinetic or Pharmacodynamic Interaction Between Memantine and Donepezil
Authors: Periclou Antonia P , Ventura Daniel , Sherman Tyler , Rao Niranjan , Abramowitz Wattanaporn T 
Published: July 2004

BACKGROUND: Memantine, a low- to moderate-affinity, uncompetitive N-methyl-d-aspartate receptor antagonist, was approved in the US for treatment of moderate to severe Alzheimer's disease in October 2003. OBJECTIVE: To determine whether an in vivo pharmacokinetic interaction exists between memantine and the acetylcholinesterase (AChE) inhibitor donepezil. METHODS: In this open-label, multiple-dose study, 24 healthy subjects (aged 18–35 y) received oral administration of memantine 10 mg on day 1. Following a 14-day washout period, subjects were orally administered donepezil 5 mg once daily for 7 days on an outpatient basis. Beginning on day 22, the donepezil dosage was doubled for 22 days to the target dose of 10 mg once daily, with the last donepezil dose concomitantly administered with memantine 10 mg on day 43. Assessments included pharmacokinetic as well as safety parameters. In addition, AChE inhibition was measured in red blood cells by radiolabeled-enzyme assay following administration of donepezil alone and after a single memantine dose. RESULTS: Data from 19 subjects who completed the study indicated no significant pharmacokinetic interactions between a single dose of memantine and multiple doses of donepezil. Percent maximum inhibition of AChE activity (mean ± SD) by donepezil was 77.8 ± 7.3% and not significantly different upon coadministration of a single dose of memantine (81.1 ± 5.7%). Two subjects withdrew due to adverse events while taking donepezil alone. Single memantine doses administered with multiple donepezil doses were well tolerated. CONCLUSIONS: The pharmacokinetic and pharmacodynamic data from this study indicated a lack of interaction between memantine and donepezil, suggesting that memantine and donepezil may be safely and effectively used in combination.
Clinical and Economic Analysis of Methicillin-Susceptible and -Resistant Staphylococcus aureus Infections
Authors: Kopp Brian J , Nix David E , Armstrong Edward P 
Published: July 2004

BACKGROUND: The rate of methicillin-resistant Staphylococcus aureus (MRSA) has increased significantly over the last decade. Previous cohort studies of patients with MRSA bacteremia have reported higher mortality rates, increased morbidity, longer hospital length of stay (LOS), and higher costs compared with patients with methicillin-susceptible S. aureus (MSSA) bacteremia. The clinical and economic impact of MRSA involving other sites of infection has not been well characterized. OBJECTIVE: To determine the clinical and economic implications of MRSA compared with MSSA infections across a variety of infection sites and severity of illnesses. METHODS: A retrospective, case—control analysis comparing differences in clinical and economic outcomes of patients with MRSA and MSSA infections was conducted at an academic medical center. Case patients with MRSA infection were matched (1:1 ratio) to control patients with MSSA infection according to age, site of infection, and type of care. RESULTS: Thirty-six matched pairs of patients with S. aureus infection were identified. Baseline characteristics of patients with MSSA and MRSA infection were similar. Patients with MRSA infections had a trend toward longer hospital LOS (15.5 vs 11 days; p = 0.05) and longer antibiotic-related LOS (10 vs 7 days; p = 0.003). Median hospital cost associated with treatment of patients with MRSA infections was higher compared with patients with MSSA infections ($16 575 vs $12 862; p = 0.11); however, this difference was not statistically significant. Treatment failure was common in patients with MRSA infection. Among patients with MSSA infections, treatment failure was associated with vancomycin use. CONCLUSIONS: Patients with MRSA infections had worse clinical and economic outcomes compared with patients with MSSA infections.
Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin
Authors: Meier Ursula , Gressner Axel M 
Published: July 2004

AbstractBackground: Recent studies point to the adipose tissue as a highly active endocrine organ secreting a range of hormones. Leptin, ghrelin, adiponectin, and resistin are considered to take part in the regulation of energy metabolism.Approach: This review summarizes recent knowledge on leptin and its receptor and on ghrelin, adiponectin, and resistin, and emphasizes their roles in pathobiochemistry and clinical chemistry.Content: Leptin, adiponectin, and resistin are produced by the adipose tissue. The protein leptin, a satiety hormone, regulates appetite and energy balance of the body. Adiponectin could suppress the development of atherosclerosis and liver fibrosis and might play a role as an antiinflammatory hormone. Increased resistin concentrations might cause insulin resistance and thus could link obesity with type II diabetes. Ghrelin is produced in the stomach. In addition to its role in long-term regulation of energy metabolism, it is involved in the short-term regulation of feeding. These hormones have important roles in energy homeostasis, glucose and lipid metabolism, reproduction, cardiovascular function, and immunity. They directly influence other organ systems, including the brain, liver, and skeletal muscle, and are significantly regulated by nutritional status. This newly discovered secretory function has extended the biological relevance of adipose tissue, which is no longer considered as only an energy storage site.Summary: The functional roles, structures, synthesis, analytical aspects, and clinical significance of leptin, ghrelin, adiponectin, and resistin are summarized.
Biochemistry of Pro-B-Type Natriuretic Peptide-Derived Peptides: The Endocrine Heart Revisited
Authors: Goetze Jens Peter 
Published: July 2004

AbstractBackground: Since the discovery of cardiac hormones almost 25 years ago, a vast amount of clinical research has identified the cardiac natriuretic peptides and their precursors as markers of heart failure. It even seems likely that the pro-B-type natriuretic peptide (proBNP)-derived peptides in plasma may become the most frequently measured peptides in the daily diagnosis and control of therapy. In contrast, the biochemistry of the peptides has received less attention.Methods: Published data available on the National Library of Medicine (NLM) were used as the basis for the review.Outcome: This review shows that the present understanding of the biochemistry of peptides is far from complete. In particular, cellular synthesis, including posttranslational precursor maturation, is poorly understood. Moreover, elimination of the precursor fragments is unknown. Elucidation of the molecular heterogeneity of proBNP products will therefore contribute to the understanding of the endocrine heart and may also have important diagnostic consequences. Above all, the different proBNP-derived peptides may not always be equal markers of the same pathophysiologic processes. A different metabolism and peripheral elimination may also impose new and peptide-specific limitations for diagnostic use.Conclusions: It is necessary to focus more on the biology of the proBNP-derived peptides. In turn, new insight into the biochemistry could pave the way for more sensitive and disease-specific assays in the clinical setting.
Organisationsübergreifendes Geschäftsprozessmanagement (Business Process Management across Organisational Boundaries)
Authors: Lindert Frank , Wiedeler Markus 
Published: July 2004

Zusammenfassung
Die zunehmende Vernetzung und Zusammenarbeit von verschiedenen Unternehmen und Organisationen stellt besondere Anforderungen an die Gestaltung der Geschäftsprozesse. Die Geschäftsprozesse der in der Regel autonomen Beteiligten müssen so aufeinander abgestimmt werden, dass eine Kooperation ohne großen Transaktionsaufwand realisiert werden kann. Eine Lösung für die Unterstützung von organisationsübergreifenden Geschäftsprozessen ist die Einführung eines Diensteansatzes, bei dem die beteiligten Organisationen ihren Beitrag an der Kooperation jeweils als Dienst bereitstellen. In diesem Artikel werden die Anforderungen dargestellt, die im Rahmen von Kooperationen zu berücksichtigen sind. Ebenso wird ein Diensteansatz für die Koordination von Geschäftsprozessen beschrieben.
Enabling Technology: Ein J2EE-basiertes Business Process Management System zur Ausführung von BPEL- und Web Service-basierten Geschäftsprozessen (Enabling Technology: A J2EE based Business Process Management System for BPEL and Web services based business processes)
Authors: Kloppmann Matthias , König Dieter , Leymann Frank , Pfau Gerhard , Roller Dieter 
Published: July 2004

Zusammenfassung
Mithilfe von Web Services und BPEL (Business Process Execution Language for Web Services) können Geschäftsprozesse und deren Interaktion mit verschiedenen Partnern beschrieben werden. Zur Ausführung der Geschäftsprozesse finden Workflow Management Systeme Verwendung. Dieser Artikel beschäftigt sich, basierend auf den Grundlagen von Web Services und BPEL, mit der Implementierung eines Workflow Management Systems. Um den Anforderungen der Geschäftswelt zu genügen, muss ein Workflow Management System sowohl langlaufende, unterbrechbare als auch kurzlaufende Geschäftsprozesse mit ihren unterschiedlichen Quality-of-Service Eigenschaften unterstützen. Die Systeme müssen robust sein, sicher und hoch verfügbar. Der Artikel beschreibt die Implementierung eines J2EE-basierten Workflow Management System, das diesen Anforderungen entspricht. Dabei wird auf die Verwendung von Message Queuing Systemen und Datenbanken eingegangen, ebenso wie auf die Integration in einen Standard Application Server und die Verwendung dort zur Verfügung stehender Transaction Manager, EJB Container, People Directory und Deployment Infrastruktur.
P2P Evolution: From File-sharing to Decentralized Workflows (P2P Entwicklung: Vom Filesharing zu dezentralisierten Workflows)
Authors: Risse Thomas , Knežević Predrag , Wombacher Andreas 
Published: July 2004

Summary
Peer-to-peer (P2P) computing is currently receiving a great deal of attention. Much of the current attention is focused on the use of P2P computing for exchanging media files. But P2P systems have actually been around for a long time and many application scenarios exist. In this paper we discuss on one hand the evolution of P2P middleware from simple file-sharing to decentralized data storage; on the other hand the impact on the future development of decentralized workflows. Building up a P2P based data storage, with similar properties as a standard data store, opens many research issues. While P2P databases enable distributed data storage, distributed control flows are considered in decentralized workflows. The paper will present several research issues addressing the collaboration and coordination problem in distributed environments without a centralized coordination instance by means of a B2B application scenario.
Dietary Niacin Intake and Mortality Among Individuals With Nonalcoholic Fatty Liver Disease
Authors: Pan Jie , Zhou Yujia , Pang Nengzhi , Yang Lili 
Published: February 2024

ImportanceEvidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.ObjectiveTo examine the association of dietary niacin intake with all-cause mortality and cardiovascular disease (CVD) mortality among individuals with NAFLD.Design, Setting, and ParticipantsThis cohort study used data from the National Health and Nutrition Examination Survey (2003-2018). In total, 4315 adults aged 20 years or older with NAFLD were included, with NAFLD defined using the United States Fatty Liver Index.ExposureDietary niacin intake levels.Main Outcomes and MeasuresWeighted Cox proportional hazards models and restricted cubic splines were used to estimate hazard ratios and 95% CIs for all-cause and CVD mortality. Data were analyzed March 1 to September 1, 2023.ResultsThis cohort study included data from 4315 participants in the analysis (mean [SD] age, 52.5 [16.2] years; 1670 participants ≥60 years [weighted, 30.9%]; 2351 men [weighted, 55.0%]). During a median (IQR) follow-up of 8.8 (4.6-11.8) years, 566 deaths were recorded, of which 197 were attributed to CVD. Compared with participants with a niacin intake of 18.4 mg or lower (the lowest tertile), the multivariable-adjusted hazard ratios for participants with a niacin intake of 26.7 mg or higher (the highest tertile) were 0.70 (95% CI, 0.50-0.96) for all-cause mortality (P = .03 for trend) and 0.65 (95% CI, 0.35-1.20) for CVD mortality (P = .16 for trend).Conclusions and RelevanceFindings from this cohort study suggest that higher dietary niacin intake may be associated with lower risk of all-cause mortality among individuals with NAFLD. There was no evident inverse association between dietary niacin intake and the risk of CVD mortality.
Diabetic Retinopathy and Quality of Life
Authors: Zayed Mohammed G. , Karsan Waseem , Peto Tunde , Saravanan Ponnusamy , Virgili Gianni , Preiss David 
Published: February 2024

ImportanceThe association between diabetic retinopathy (DR) and quality of life (QoL) has not been thoroughly investigated.ObjectiveTo investigate the association between DR and both vision-related QoL (VRQoL) and general health-related QoL (HRQoL).Data SourcesMEDLINE, EBSCO, Embase, and Web of Science were searched from their inception to April 2022.Study SelectionStudies included adults with DR and a measure of QoL.Data Extraction and SynthesisPreferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Two assumption-free meta-analyses were conducted. Analysis 1 included studies with participants without DR as the referent group to which QoL scores of participants with DR, grouped according to DR severity, were compared. Analysis 2 included all studies with participants with DR and a measure of QoL. QoL scores were pooled within categories of DR severity, and comparisons were made between these categories.Main Outcome and MeasuresQoL measured using HRQoL and VRQoL scales.ResultsA total of 93 articles were included: 79 in the meta-analyses and 14 in the narrative results. VRQoL was recorded in 54 studies, HRQoL in 26, and both in 13 studies. The most commonly used scales were the National Eye Institute 25-item Visual Function Questionnaire (VFQ-25) (n = 49) for VRQoL and the Short Form (SF) Health Survey (n = 18) for HRQoL. Thirty-five studies reported VFQ-25 composite scores. Analysis 1 consisted of 8 studies including 1138 participants with DR and 347 participants without DR. Compared with participants without DR, the composite VFQ-25 score was 3.8 (95% CI, 1.0-6.7) points lower in those with non–vision-threatening DR (NVTDR), 12.5 (95% CI, 8.5-16.5) lower in those with any DR, and 25.1 (95% CI, 22.8-27.2) lower in VTDR (P &amp;lt; .001 for trend). Analysis 2 consisted of 35 studies including 6351 participants with DR. The pooled mean VFQ-25 composite score was 91.8 (95% CI, 91.0-92.7) for participants with NVTDR, 77.6 (95% CI, 76.9-78.3) for any DR, and 73.2 (95% CI, 72.6-73.7) for VTDR (P &amp;lt; .001 for trend). HRQoL scores had weak or no associations with NVTDR and strong associations with VTDR.Conclusions and RelevanceThis study found that VRQoL declined with the presence and severity of DR. Interventions to reduce progression of DR at both early and more advanced stages could improve VRQoL.
Tailored Design Ti4+ Coordination via Coplanar Carboxyl and Hydroxyl Groups Toward High Purity TiO2(B) with Ultrafast Li+ Storage
Authors: Ke Jinlong , Li Meichen , Chen Shi , Xiao Peitao , Hu Aiping , Xu Chaohe , Gao Peng , Liu Jilei 
Published: February 2024

AbstractTiO2(B) is a promising anode material for lithium‐ion batteries (LIBs) due to its fast lithiation/delithiation kinetics, however, its thermodynamic metastable nature makes it difficult to synthesize pure phase, which significantly affects its lithium storage capability. Herein, the structural evolution from precursor to TiO2(B) is systematically investigated and it is revealed that the formation of high‐purity monoclinic HTO (hydrogen titanate) precursor is the key to preparing TiO2(B) with high purity, which can be achieved via tailored‐design the solvent structures of Ti4+ in the precursor solution. Glycolic acid (GA) is favorable for the synthesis of high‐purity HTO, benefiting from its simplest spatial structure and coplanar carboxyl and hydroxyl groups for Ti4+ coordination, further leading to the formation of TiO2(B) with a high phase purity of 98.83% that exhibits excellent rate capability (80.5% capacity retention with current densities increased from 1 to 30 C), thus making it a promising candidate for simultaneous energy and power density LIBs anode.
Mnox Nanoenzyme Armed CAR‐NK Cells Enhance Solid Tumor Immunotherapy by Alleviating the Immunosuppressive Microenvironment
Authors: Duan Jiazhi , Zhao Songbo , Duan Yuyao , Sun Dawei , Zhang Gaorui , Yu Dexin , Lou Yalin , Liu Huimin , Yang Shanshan , Liang Xiaohong , Ma Chunhong , Liu Hong , Qiu Jichuan , Gao Lifen , Sang Yuanhua 
Published: February 2024

AbstractAdoptively transferred cells usually suffer from exhaustion, limited expansion, and poor infiltration, partially attributing to the complicated immunosuppressive microenvironment of solid tumors. Therefore, it is necessary to explore more effective strategies to improve the poor tumor microenvironment (TME) to efficaciously deliver and support extrinsic effector cells in vivo. Herein, an intelligent biodegradable hollow manganese dioxide nanoparticle (MnOX) that possesses peroxidase activity to catalyze excess H2O2 in the TME to produce oxygen and relieve the hypoxia of solid tumors is developed. MnOX nanoenzymes modified with CD56 antibody could specifically bind CAR‐NK (chimeric antigen receptor modified natural killer) cells. It is demonstrated that CAR‐NK cells incorporated with MnOX nanoenzymes effectively infiltrate into tumor tissues with an improved TME, which results in superior antitumor activity in solid tumor‐bearing mice. The antibody connection between MnOX nanoenzymes and CAR‐NK endows the lowest efficient dosage of MnOX. This study features a smart synergistic immunotherapy approach for solid tumors using MnOX nanoenzyme‐armed CAR‐NK cells, which would provide a valuable tool for immunocyte therapy in solid tumors.