bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare professionals’ perspectives on optimizing pain care-related education at a Canadian children’s hospital: A qualitative study
Authors: Kammerer Elise , Linkiewich Delane , Ali Samina 
Published: November 2023

Abstract

Objectives
Pain affects all children and youth, yet acute and procedural pain remains undertreated in Canadian hospitals. To improve pain management practices in paediatric hospitals, it is necessary to understand how healthcare professionals (HCPs) wish for educational interventions to be designed to improve their pain management practice.

Methods
Semi-structured interviews were conducted with 18 HCPs between October and December 2020. Snowball sampling was used to first recruit interested members from the hospital’s Pediatric Pain Management Committee. Interviews were conducted per participant preference and included Zoom, telephone, and in-person interviews. Recruitment ceased when data were determined sufficiently rich. A thematic analysis of verbatim transcripts and reflexive field notes were used to create a data set focused on knowledge mobilization and clinical education.

Results
Three core themes were identified: (a) the necessity for just-in-time education for HCPs; (b) the availability of clinical pain champions to educate staff; and (c) the provision of resources to educate children and their families about available pain management interventions. Just-in-time education included suggestions for in-service training, hands-on training, and regular updates on the latest research. Pain champions, including clinical nurse educators, were stressed as being important in motivating staff to improve their pain management practices. Participants noted the lack of resources for patient and family education on pain management and suggested providing more multimodal resources and educational opportunities.

Conclusion
Having local champions introduce pain management initiatives and just-in-time education positively impacts the implementation climate, which also helps HCPs provide evidence-based education and resources to patients and families.
S-nitrosylation of the transcription factor MYB30 facilitates nitric oxide–promoted seed germination in Arabidopsis
Authors: Zhao Hongyun , Ma Liang , Shen Jialu , Zhou Huapeng , Zheng Yuan 
Published: November 2023

Abstract
The gaseous signaling molecule nitric oxide (NO) plays an important role in breaking seed dormancy. NO induces a decrease in abscisic acid (ABA) content by transcriptionally activating its catabolic enzyme, the ABA 8′-hydroxylase CYP707A2. However, the underlying mechanism of this process remains unclear. Here, we report that the transcription factor MYB30 plays a critical role in NO-induced seed germination in Arabidopsis (Arabidopsis thaliana). MYB30 loss-of-function attenuates NO-mediated seed dormancy breaking. MYB30 triggers a NO-induced decrease in ABA content during germination by directly promoting CYP707A2 expression. NO induces S-nitrosylation at Cys-49 of MYB30 and enhances its transcriptional activity. Conversely, the ABA receptors PYRABACTIN RESISTANCE1 (PYR1)/PYR1-LIKE (PYL)/REGULATORY COMPONENTS OF ABA RECEPTORS (RCAR) interact with MYB30 and repress its transcriptional activity. ABA promotes the interaction between PYL4 and MYB30, whereas S-nitrosylation releases the PYL4-mediated inhibition of MYB30 by interfering with the PYL4-MYB30 interaction. Genetic analysis showed that MYB30 functions downstream of PYLs during seed dormancy and germination in response to NO. Furthermore, MYB30 mutation significantly represses the reduced dormancy phenotype and the enhanced CYP707A2 expression of the pyr1 pyl1 pyl2 pyl4 quadruple mutant. Our findings reveal that S-nitrosylation of MYB30 precisely regulates the balance of seed dormancy and germination, providing insights into the underlying mechanism of NO-promoted seed germination.
Risk attitudes and innovation in Dutch arable farming
Authors: Höhler Julia , Tensi Annika , Sok Jaap 
Published: November 2023

Abstract
On-farm innovations have the potential to increase both agricultural productivity and income while mitigating environmental impacts. However, as adopting innovations can lead to risks, it is important to understand the role of farmers’ risk attitudes. We quantified Dutch arable farmers’ risk attitudes based on the cumulative prospect theory (CPT) and used the benefit of the doubt approach to obtain an innovation index based on expert elicitations and adopted innovations. Subsequently, we used a fractional response model to test our pre-registered hypothesis and investigate the association between the parameters of farmers’ risk attitude and farm-level innovation. We find no statistically significant association between CPT parameters and the innovation index. Our results therefore cast doubts on the potential of revealed risk preferences to understand real-world behaviour.
Sesta Rima as a Mode of Imitation: Hybrid Forms in Anglo-Italian Verse
Authors: Sullivan Michael J 
Published: November 2023

Abstract
This article finds in the Italianate form of sesta rima an additional strand of influence on English ottava rima in the nineteenth century. It explores the verse history that has led to six-line stanzas becoming a formal training ground for octave rhymes, and conducts the first sustained examination of Byron’s engagement with the Italianate sestain. Drawing together Byron’s Italian reading, his correspondence, and his manuscript experiments, the article opens up a cluster of poems between 1813 and 1816 which reveal how his movements towards ottava rima predate his arrival in Italy and intertwine with the history of sesta rima. Only two lines shorter than ottava rima and sharing its pattern of ab rhymes closed by a cc couplet, the stanza has received sparse attention in criticism of modern verse. Exploring how sesta rima became a mode for parodying ottava rima, the paper’s second part examines how the young Tennyson shaped his manuscript rhymes to emulate a Byronic voice. Closely engaging with the genesis and uses of these stanzas in both poets’ manuscripts, the article forms a wider case study in experimental stanza switching and hybrid forms in Romantic and post-Romantic verse.
Effects of transdisciplinary research on scientific knowledge and reflexivity
Authors: Marg Oskar , Theiler Lena 
Published: November 2023

Abstract
Transdisciplinary research (TDR) is conceptualized as not only providing societal effects but also benefiting academia. However, recent literature on the evaluation of TDR has focused almost entirely on the societal effects of TDR. A discussion of the scientific effects of TDR is needed to do justice to the potential of this research mode. To date, little empirical research has focused on the effects of TDR on science. Our explorative study addresses this gap. The empirical basis are qualitative interviews with scientists engaged in transdisciplinary research and anchored in three sub-disciplines: environmental sociology, sustainable chemistry, and participatory health research. We identify as main effects of the transdisciplinary research mode: changes in the understanding of scientific problems, changes in the quality of scientific insights, and the promotion of a reflexive turn in science.
Transcriptome and photosynthetic analyses provide new insight into the molecular mechanisms underlying heat stress tolerance in Rhododendron × pulchrum Sweet
Authors: Cheng Hefeng , Wan Ziyun , Xu Yanxia , Shen Jianshuang , Li Xueqin , Jin Songheng 
Published: November 2023

Abstract
Rhododendron species provide excellent ornamental use worldwide, yet heat stress (HS) is one of the major threats to their cultivation. However, the intricate mechanisms underlying the photochemical and transcriptional regulations associated with the heat stress response in Rhododendron remain relatively unexplored. In this study, the analyses of morphological characteristics and chlorophyll fluorescence (ChlF) kinetics showed that HS (40 °C/35 °C) had a notable impact on both the donor’s and acceptor’s sides of photosystem II (PSII), resulting in reduced PSII activity and electron transfer capacity. The gradual recovery of plants observed following a 5-day period of culture under normal conditions indicates the reversible nature of the HS impact on Rhododendron × pulchrum. Analysis of transcriptome data unveiled noteworthy trends: four genes associated with photosynthesis-antenna protein synthesis (LHCb1, LHCb2 and LHCb3) and the antioxidant system (glutamate-cysteine ligase) experienced significant down-regulation in the leaves of R. × pulchrum during HS. Conversely, aseorbate peroxidase and glutathione S-transferase TAU 8 demonstrated an up-regulated pattern. Furthermore, six down-regulated genes (phos-phoenolpyruvate carboxylase 4, sedoheptulose-bisphosphatase, ribose-5-phosphate isomerase 2, high cyclic electron flow 1, beta glucosidase 32 and starch synthase 2) and two up-regulated genes (beta glucosidase 2 and UDP-glucose pyrophosphorylase 2) implicated in photosynthetic carbon fixation and starch/sucrose metabolism were identified during the recovery process. To augment these insights, a weighted gene co-expression network analysis yielded a co-expression network, pinpointing the hub genes correlated with ChlF dynamics’ variation trends. The cumulative results showed that HS inhibited the synthesis of photosynthesis-antenna proteins in R. × pulchrum leaves. This disruption subsequently led to diminished photochemical activities in both PSII and PSI, albeit with PSI exhibiting heightened thermostability. Depending on the regulation of the reactive oxygen species scavenging system and heat dissipation, photoprotection sustained the recoverability of R. × pulchrum to HS.
The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review
Authors: Pennings Alexander J. , van der Velden Brecht A. , Kloft Maximilian , Kooreman Loes F. S. , Kleijnen Jos M. P. , Breukink Stephanie O. , Beets Geerard L. , Grabsch Heike I. , Melenhorst Jarno 
Published: November 2023

Objective:
In this review, we aim to provide an overview of literature on lymph node (LN) histomorphological features and their relationship with the prognosis in colorectal cancer (CRC).

Background:
Lymph nodes play a crucial role in the treatment and prognosis of CRC. The presence of LN metastases considerably worsens the prognosis in CRC patients. Literature has shown that the total number of LNs and the number negative LNs (LNnegs) has prognostic value in CRC patients. In esophageal carcinoma, LN size seems to be surrogate of the host antitumor response and a potentially clinically useful new prognostic biomarker for (y)pN0 esophageal carcinoma.

Methods:
A comprehensive search was performed in Pubmed, Embase, Medline, CINAHL, and the Cochrane library in March 2021. The PRISMA guidelines were followed. Only studies focusing on histomorphological features and LN size and their relation to overall survival were selected.

Results:
A total of 9 unique articles met all inclusion criteria and were therefore included in this systematic review. Six of these studies investigated HMF (eg, paracortical hyperplasia, germinal center predominance, and sinus histiocytosis) and 4 studies LNneg size and their relationship with overall survival. The presence of paracortical hyperplasia and an increased number of large LNnegs is related to a more favorable prognosis in CRC.

Conclusion:
The results of this systematic review seem to support the hypothesis that there is a relationship between the host antitumor response reflected in different histomorphological reaction patterns visible in LNnegs and LNneg size related to survival in CRC patients.
Patient-reported symptoms and interest in symptom monitoring in HCC treated with locoregional therapies: A qualitative study
Authors: Moon Andrew M. , Cook Sarah , Swier Rachel M. , Sanoff Hanna K. , Kappelman Michael D. , Wagner Lynne I. , Barritt A. Sidney , Singal Amit G. , Shah Neil D. , Mauro David M. , Yanagihara Ted K. , Gerber David A. , Fried Michael W. , Brown Cristal , Waheed Myra , Teal Randall , Evon Donna M. 
Published: November 2023

Background:
Patient-reported outcomes (PRO) measures relevant to domains most important to patients with HCC who received locoregional therapies are needed to advance patient-centered research. Furthermore, electronic PRO monitoring in clinical care has been shown to reduce hospitalizations and deaths in patients with other cancers. We conducted a qualitative study among patients with HCC who recently received locoregional therapies to (1) identify common and distressing posttreatment symptoms to prioritize PRO domain selection and (2) gauge interest in an electronic PRO symptom monitoring system.

Methods:
We performed semi-structured telephone interviews among adult patients who received locoregional therapies (median of 26 days after treatment) for treatment-naïve HCC at a single tertiary care center. Interviews were conducted until thematic saturation was reached. Qualitative content analysis was conducted to identify emerging themes and sub-themes.

Results:
Ten of 26 patients (38%) reported at least 1 symptom before treatment. In contrast, all participants (n = 26) with recently treated HCC reported at least 1 posttreatment physical symptom, with the most common being appetite loss (73%), fatigue (58%), abdominal pain (46%), and nausea (35%). Most participants (77%) stated they saw potential benefits in posttreatment ePRO symptom monitoring.

Conclusions:
Posttreatment symptoms after HCC locoregional therapies are common and often severe. These data can inform and prioritize PRO domain selection. Patients are interested in ePRO monitoring to monitor and proactively address posttreatment symptoms. Given the clinical benefits in patients with metastatic cancers, ePRO monitoring warrants investigation in patients with HCC.
Thyroid tuberculosis associated with papillary microcarcinoma: case report and review of literature
Authors: Elkrimi Zineb , Rsaissi Chaimae , Bijou Walid , Oukessou Youssef , Rouadi Sami , Abada Redallah , Roubal Mohamed , Mahtar Mohamed 
Published: November 2023

Introduction:
Thyroid tuberculosis (TB) is extremely rare. Infection may first occur in the thyroid gland or may be secondary to TB in other parts of the body. The diagnosis is rarely made clinically because the disease’s variable presentation often resembles that of a malignancy or an euthyroid nodular goiter.

Case report:
We present the case of a 40-year-old woman, who presented multiple thyroid nodules in both lobes. Two of these nodules were classified as EU-TIRADS V (European Thyroid Imaging and Reporting Data System). The ultrasound also found an adenopathy of the inferior part of the jugular lymphatic chain, in favor of malignancy. The histopathological examination after total thyroidectomy showed thyroid TB, associated to a papillary microcarcinoma of the right thyroid lobe, and the final examination of the adenopathy showed similar granulomas with caseous necrosis, and no signs of metastasis.

Clinical discussion:
Thyroid TB is very rare. Its diagnosis is difficult due to a lack of specific signs and symptoms, which is why the diagnosis is most commonly made on pathological examination after thyroid surgery. It is well known that mycobacterial infection creates an environment of chronic and persistent inflammation, with possible DNA damage. This can create a microenvironment that is highly conductive to carcinogenesis, which could explain the discovery of papillary microcarcinoma in addition to thyroid TB in our patient.

Conclusion:
This report presents a rare case of malicious growth development of thyroid nodules and thyroid TB. Therefore, physicians must always be vigilant when managing thyroid nodules, as there is always the possibility of malignant lesions associated to an inflammatory or infectious cause.
Prostate cancer among Saudis: a registry review
Authors: Alasker Ahmed , Arabi Tarek Z. , Alghafees Mohammad A. , Sabbah Belal N. , Abdul Rab Saleha , Alageel Abdulrahman K. , Abouelkhair Ahmed Emad , Abdulwali Abdulmoiz Kaiser , Al Hennawi M. Mohanad Imad , Fallatah Waleed , Musalli Ziyad F. , Noureldin Yasser A. 
Published: November 2023

Background:
Policy makers in Saudi Arabia greatly rely on published studies to make major public health decisions. Prostate cancer (PCa) studies in Saudi Arabia are either outdated or limited to local regions.

Aim:
The authors aim to analyze the Saudi Cancer Registry to determine the incidence of PCa across all regions of the Kingdom and the risk factors of poor prognosis in the population.

Methods:
Patients diagnosed with primary PCa from 1 January 2008 to 31 December 2017 were included in the study from the Saudi Cancer Registry. Incidence rates and risk factors for poor survival were calculated.

Results:
A total of 3607 PCa patients were retrieved. PCa incidence rates ranged from 0.2 to 1.4 per 100 000. Most of the patients were aged 60 and older (86.5%; n=3120), married (97%; n=3497) and lived in the central region (38.1%; n=1375). The mean age at diagnosis was 71.1 (10.8) years. Over half of all tumors were poorly differentiated (64.2%; n=2317), and localized (60.4%; n=2180). The all-time metastasis rate reached 31.4% (n=1131). The lowest mean survival was in those with distant metastasis (P=0.039). Age groups, marital status, tumor morphology, place of residency, and grade were not proven to significantly influence survival.

Conclusion:
The high metastasis rate and evidence of a greater incidence of newly diagnosed metastatic PCa indicate that the idea of select screening for certain high-risk populations is not farfetched. The authors encourage the promotion of awareness regarding PCa risk factors and screening to optimize prognosis and minimize late presentations and high metastasis rates.
Quantitative Detection and Follow-Up of Intracranial Hypertension in Craniosynostosis: An Optical Coherence Tomography Study
Authors: den Ottelander Bianca K. , van de Beeten Stephanie D. C. , Yang Sumin , van Veelen M. L. C. , Tasker Robert C. , Loudon Sjoukje E. , Mathijssen Irene M. J. 
Published: November 2023

Background:
In patients with craniosynostosis, the authors evaluated the diagnostic accuracy of fundoscopy and optical coherence tomography (OCT) to detect intracranial hypertension (ICH), the time course of retinal thickness after treatment of ICH, and the relationship between high hyperopia (HH) and fundoscopy/OCT scan findings.

Methods:
Patients with syndromic, multisuture, unicoronal, unilambdoid, or sagittal synostosis visiting the authors’ national center were included in this longitudinal cohort study and formed a consecutive series. Retinal layers on OCT, OCT fundus images, and fundoscopy results were evaluated. ICH was scored according to presence of abnormal intracranial pressures, hydrocephalus, progressive cerebellar tonsillar herniation or fingerprinting, and growth arrest. Diagnostic accuracy of OCT, fundoscopy, and fundus image; the time course of retinal thickness after ICH; and interference of HH were analyzed using linear mixed models.

Results:
A total of 577 OCT scans in 307 patients were included. ICH was found in 7.2%. Combining total retinal thickness (TRT), OCT fundus imaging and fundoscopy resulted in a sensitivity of 76% and 81% specificity to detect signs of ICH. TRT was increased in patients who had had signs of ICH versus patients who had never had signs of ICH (β +44.9 µm in patients who had had ICH [95% CI, 9.0 to 80.8]; P = 0.01). TRT decreased to normal in the years after surgery (β −3.6 µm/yr [95% CI, −7.2 to −0.05]; P = 0.047). There were greater odds of having increased TRT in patients with HH (OR, 2.9 [95% CI, 1.1 to 7.6]; P = 0.03).

Conclusions:
The correlation among TRT, OCT fundus image, fundoscopy, and particularly the combination of these measures with intracranial pressure surrogate markers is fair. Increased TRT in the presence of a clinical suspicion of ICH warrants further screening.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Diagnostic, III.
Realizing Upper Extremity Bionic Limbs: Leveraging Neuroprosthetic Control Strategies
Authors: Ganesh Kumar Nishant , Chestek Cynthia A. , Cederna Paul S. , Kung Theodore A. 
Published: November 2023

Summary:
Innovations in prosthetic devices and neuroprosthetic control strategies have opened new frontiers for the treatment and rehabilitation of individuals undergoing amputation. Commercial prosthetic devices are now available with sophisticated electrical and mechanical components that can closely replicate the functions of the human musculoskeletal system. However, to truly recognize the potential of such prosthetic devices and develop the next generation of bionic limbs, a highly reliable prosthetic device control strategy is required. In the past few years, refined surgical techniques have enabled neuroprosthetic control strategies to record efferent motor and stimulate afferent sensory action potentials from a residual limb with extraordinary specificity, signal quality, and long-term stability. As a result, such control strategies are now capable of facilitating intuitive, real-time, and naturalistic prosthetic experiences for patients with amputations. This article summarizes the current state of upper extremity neuroprosthetic devices and discusses the leading control strategies that are critical to the ongoing advancement of prosthetic development and implementation.
Accretion–ablation mechanics
Authors: Pradhan Satya Prakash , Yavari Arash 
Published: November 2023

In this paper, we formulate a geometric nonlinear theory of the mechanics of accreting–ablating bodies. This is a generalization of the theory of accretion mechanics of Sozio & Yavari (Sozio & Yavari 2019
J. Nonlinear Sci.
29
, 1813–1863 (doi:10.1007/s00332-019-09531-w)). More specifically, we are interested in large deformation analysis of bodies that undergo a continuous and simultaneous accretion and ablation on their boundaries while under external loads. In this formulation, the natural configuration of an accreting–ablating body is a time-dependent Riemannian

3

-manifold with a metric that is an unknown
a priori
and is determined after solving the accretion–ablation initial-boundary-value problem. In addition to the time of attachment map, we introduce a time of detachment map that along with the time of attachment map, and the accretion and ablation velocities, describes the time-dependent reference configuration of the body. The kinematics, material manifold, material metric, constitutive equations and the balance laws are discussed in detail. As a concrete example and application of the geometric theory, we analyse a thick hollow circular cylinder made of an arbitrary incompressible isotropic material that is under a finite time-dependent extension while undergoing continuous ablation on its inner cylinder boundary and accretion on its outer cylinder boundary. The state of deformation and stress during the accretion–ablation process, and the residual stretch and stress after the completion of the accretion–ablation process, are computed.

This article is part of the theme issue ‘Foundational issues, analysis and geometry in continuum mechanics’.