bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linkages between soil nutrient turnover and above‐ground crop nutrient metabolism: The role of soil microbes
Authors: Fang Wensheng , Tian Wenfeng , Yan Dongdong , Li Yuan , Cao Aocheng , Wang Qiuxia 
Published: February 2025

AbstractWith global agricultural practices increasingly focused on sustainability and efficiency, deciphering the complex relationship between soil nutrient turnover and crop nutrient uptake is critical for advancing crop productivity and environmental resilience. This study focuses on the nitrogen transformation process following dazomet soil fumigation and examines how soil microorganisms influence both soil nitrogen cycling and above‐ground crop nitrogen metabolism. Fumigation led to significant changes, with ammonium nitrogen increasing by 18.89%−94.82% and nitrate nitrogen decreasing by 30.20%−90.21% in tobacco roots, stems, and leaves. Fumigation also caused a notable shift in the soil microbial community, inhibiting ammonium‐oxidizing microorganisms while stimulating denitrifying microbes. These changes not only disrupted the nitrogen balance‐reducing soil nitrification by 72.91%−86.51% and increasing denitrification by 197%−324% but also had a cascading effect on above‐ground crop nitrogen metabolism. By altering the composition of microbial communities, the process directly influenced soil nutrient turnover, subsequently impacting nutrient availability and distribution in crop. The disruption in nitrogen balance further led to changes in the expression of key nitrogen metabolism enzymes and transporter genes. Specifically, genes related to nitrate and ammonium transporters, as well as amino acid and nitrogen metabolism enzymes, were upregulated. Structural equation modeling confirmed that the shifts in the microbial community were central to driving changes in both soil nutrient turnover and nitrogen distribution in the crop. These findings underscore the critical role of soil microbial communities as a link between soil nutrient cycling and above‐ground nutrient metabolism, highlighting their importance in regulating plant nutrient absorption and utilization. This suggests that optimizing microbial management strategies could lead to significant improvements in crop nutrient efficiency.
FoMO and Socio‐Emotional e‐Competencies as Predictors of Media Multitasking, Phubbing and Cybergossip in University Students: Transnational Differences Between Mexico and Spain by Gender
Authors: González Martha Leticia Gaeta , Hernández Santos Orejudo , Cebollero‐Salinas Ana 
Published: February 2025

ABSTRACTThere are clear signs of the growing use of the internet across all cultures, which generate new behaviors in the virtual environment such as media multitasking, phubbing, and cybergossip, all associated with online risks and less positive modes of socialization. FoMO (Fear of Missing Out) along with virtual emotional experiences could be relevant predictors, where literature suggests that FoMO is a trigger for problematic social media use, and socio‐emotional e‐competencies facilitate adaptive behaviors in virtual environments. Hence, understanding which variables predict these phenomena is crucial and whether they can be generalized across different countries. The objective of this study is to analyze whether two dimensions of socio‐personal development used to interact in virtual environments, FoMO (Fear of Missing Out) and socio‐emotional e‐competencies (e‐COM), are predictors of different cyberbehaviors (cybergossip, phubbing and media multitasking) in university students from two different countries. It also aims to verify if socio‐emotional e‐competencies act as a moderator of this relationship. In order to achieve this, we used a sample of 1524 university students from Mexico and Spain (19.74 years old). The results of the path analysis models show that FoMO is the strongest predictor of the three online behaviors regardless of country and gender, especially in the case of phubbing. In addition, socio‐emotional e‐competencies help to explain the behaviors in a differential way for each country, and the dimension of e‐self‐control of impulsivity plays a moderating role in FoMO in the case of phubbing and media multitasking. Some differences between countries and genders are discussed.
Prevalence and Prognostic Significance of Sarcopenia in Gynecologic Oncology: A Systematic Review and Meta‐Analysis
Authors: Jiang Chen , Chen Qin , Yu Danping , Zhou Qianqian , Tang Cong , Qiao Chenping 
Published: February 2025

ABSTRACTBackgroundSarcopenia in gynaecologic oncology patients has garnered increasing attention, but its prevalence has not been comprehensively summarized. This study aims to integrate the prevalence of sarcopenia in this population through systematic evaluation and meta‐analysis, providing a reference for future clinical research.MethodsA computerized search of PubMed, Embase, The Cochrane Library, Web of Science and other databases was conducted to collect relevant literature on the prevalence of sarcopenia in gynaecologic oncology patients and its impact on prognosis, with a timeframe from the inception of the databases to July 2024. Two researchers independently screened the literature, extracted information and assessed the risk of bias. After evaluating the risk of bias, a meta‐analysis was performed using RevMan5.4 software. This systematic review was conducted using a previously published study protocol (PROSPERO: CRD42024565094).ResultsA total of 24 studies encompassing 4136 patients were included. The meta‐analysis revealed that the prevalence of sarcopenia in gynaecologic oncology patients was 38.8% (I2 = 96%, 95% CI [0.49–0.79], p < 0.001). Subgroup analysis indicated that the prevalence of sarcopenia was higher among patients with endometrial cancer or ovarian cancer, those over 60 years of age, individuals with a body mass index (BMI) greater than 25 kg/m2, those diagnosed using the psoas muscle index (PMI) and patients assessed at the L4 vertebra. Overall survival (OS) was significantly lower in patients with gynaecologic tumours combined with sarcopenia compared to those with gynaecologic tumours alone. However, no significant differences were observed in progression‐free survival (PFS), mortality or length of hospital stay.ConclusionSarcopenia has a high prevalence in gynaecologic oncology patients. Healthcare professionals should prioritize early screening and preventive measures for high‐risk patients.
Metabolic Reprogramming in Epstein–Barr Virus Associated Diseases
Authors: Yee Tiffany Melanie , Wang Liang Wei 
Published: February 2025

ABSTRACTEpstein–Barr virus (EBV) is the first human cancer‐causing viral pathogen to be discovered; it has been epidemiologically associated with a wide range of diseases, including cancers, autoimmunity, and hyperinflammatory disorders. Its evolutionary success is underpinned by coordinated expression of viral transcription factors (EBV nuclear antigens), signaling proteins (EBV latent membrane proteins), and noncoding RNAs, which orchestrate cell transformation, immune evasion, and dissemination. Each of those activities entails significant metabolic rewiring, which is achieved by viral subversion of key host metabolic regulators such as the mammalian target of rapamycin (mTOR), MYC, and hypoxia‐inducible factor (HIF). In this review, we systemically discuss how EBV‐encoded factors regulate metabolism to achieve viral persistence and propagation, as well as potential research questions and directions in EBV‐driven metabolism.
Pharmaceuticals, Pesticides, and PFAS: Quantifying Endocrine Disrupting Compounds in Plastics and Fish Tissues Using Solvent Extraction and LC‐MS/MS
Authors: Dolling Sophie , Reis‐Santos Patrick , Williams Mike , Gillanders Bronwyn M. 
Published: February 2025

ABSTRACTThe rise of plastic pollution in marine environments has been heavily documented, with particular focus on the physical impacts the plastics can have on biota. But, plastics also sorb a range of hydrophobic chemical pollutants, acting as vectors for the transportation of these compounds throughout marine environments. Therefore, an analytical method that can target both marine biota and plastic matrices will be key to advance our understanding of the link between chemicals in the environment, plastic pollution, and effects on biota. Here, an efficient method for the detection and quantification of a broad suite of compounds in marine samples was developed. Five extraction methods were trialed for the analysis of 21 pesticides, PFAS, and pharmaceuticals in biota and plastics. This included three ultrasonic extraction methods and two QuEChERS methods. Ultrasonic extraction in acetonitrile with a microcentrifuge step then concentration by Bond Elut Carbon SPE resulted in best recovery across most compounds. Of the 21 compounds trialed, 16 were efficiently quantified. Method limits of quantification and detection were between 0.02 and 4.81 ppb (mLODs) and between 0.06 and 14.60 ppb (mLOQs). This method is widely applicable to a range of marine environments and supports routine evaluations of environmental safety and monitoring protocols.
Quality Consistency Evaluation of Chemical Composition and Pharmacology of Pheretima aspergillum Dispensing Granules and Traditional Decoction Based on HPLC, GC‐IMS, and Animal Experiments
Authors: Li Han , Wu Xiaoming , Miao Yan , Dong Fengyu , Gui Xinjing , Wang Panpan , Li Xuelin , Liu Ruixin 
Published: February 2025

ABSTRACTThis study investigates the consistency of quality between the traditional decoction (TD) of Pheretima aspergillum and its dispensing granule decoction (DGD) by examining their chemical composition and antithrombotic efficacy. We first determined the nucleoside components, protein content, and volatile compounds in 10 batches of TD and 9 batches of DGD sourced from three manufacturers using high‐performance liquid chromatography (HPLC), UV–vis spectrophotometry, and gas chromatography ion mobility spectrometry (GC‐IMS). Next, we assessed antithrombotic efficacy by measuring the relative length of tail thrombosis and calculating the thrombus inhibition rates at 24 and 48 h. Our comprehensive analysis revealed that the concentrations of hypoxanthine, uridine, inosine, adenosine, and proteins in TD were significantly higher than those in DGD. Moreover, the types and concentrations of volatile compounds in TD and DGD exhibited substantial differences, with 19 volatile compounds identified as differentially present between the two decoctions. Despite these compositional differences, both decoction types demonstrated equivalent antithrombotic efficacy. Overall, the quality of DGD from manufacturers A and B aligned closely with that of TD. However, TD exhibited a higher overall quality compared to DGD, while both decoctions maintained consistent antithrombotic efficacy.
Hypopharyngeal Amyloidosis: A Rare Cause of Dysphagia
Authors: Buell Jane B. , Schuman Ari D. , Ongkasuwan Julina , Szymanowski Adam 
Published: February 2025

AbstractAmyloidosis localized to the head and neck most commonly affects the laryngo‐tracheobronchial tree or tongue. It rarely affects the hypopharynx, with only 3 cases reported in literature. All of these cases describe females presenting with hypopharyngeal amyloid masses and associated multiple myeloma or monoclonal gammopathy of undetermined significance. They were treated with chemotherapy and CO2 laser, respectively. In comparison, our case identifies a 69‐year‐old female, with a history of MALT lymphoma but no concurrent malignancy. She initially presented with dysphagia and was diagnosed with hypopharyngeal amyloidosis. After 532 nm potassium titanyl phosphate laser treatment, she ultimately felt improvement in her dysphagia. Laryngoscope, 2025
Soil Erosion Rates Via 210Pbex, 137Cs and USLE Model in El Rmel Watershed, NE Tunisia
Authors: Ben Cheikha Lilia , Mabrouk El Asmi Amina , Askri Boubaker , Oueslati Mansour , Gharbi Foued , Attia Rafla , Aouedi Thabet 
Published: February 2025

ABSTRACTSoil erosion is a severe environmental and agricultural phenomenon which can be accelerated with climate change and land use, particularly in the Mediterranean region. In Tunisia, studies on the spatial distribution of erosion and deposition patterns can help to effectively implement soil and water conservation practices. Accordingly, the main objective of this research was to estimate soil erosion rates in two cultivated soils (SE1 and SE2), at El Rmel watershed of northeastern Tunisia. Three different time scales were observed via three tools, the 137Cs, the 210Pbex radioisotopes and the USLE model. The FRN's conversion mass balance model 2 (MBM2) was used to convert activities into erosion rates. Based on the 137Cs, 210Pbex, and USLE model, the mean erosion rates were, respectively, 37, 52, and 33 t ha−1 year−1, at the cereal cultivated SE1 site and 4, 9, and 6 t ha−1 year−1, at the olive tree cultivated SE2 site. It is supposed that the difference in time scale expressed by the three methods (100 years by 210Pbex, 60 years by 137Cs, and 40 years by USLE), may have had a notable impact on the discrepancy in estimated erosion rates. The mean farm slope for SE1 and SE2 were, respectively, 14% and 8% and tillage was through three operations per year. Furthermore, the cereal crops site characterized by steep slopes show much higher erosion rates. Consequently, planting olive trees will be very helpful in reducing soil erosion and will be of great impact either environmentally and/or economically.
The First Evidence for the Role of ACVR2A Gene Fetal Genotype in Preeclampsia Susceptibility
Authors: Honarpour Asal , Majd Ahmad , Sadeghi Hossein , Jamaldini Sayedhamid , Rahimi Maryam , Kazemzadeh Paniz , Mirfakhraie Reza 
Published: February 2025

ABSTRACTBackgroundThe activin A receptor type 2A gene (ACVR2A) plays an important role in normal gestation, particularly in decidualization, trophoblastic invasion, and placentation. Although several studies have investigated the association between ACVR2A maternal variants and preeclampsia (PE) susceptibility; however, controversial results were obtained. Moreover, in none of the previous studies, the role of ACVR2A fetal variants was explored. The aim of the present study was to investigate the role of ACVR2A rs1424954 and rs1424941 polymorphisms in PE susceptibility considering the impact of both fetal and maternal genotypes.MethodsFor genotyping of ACVR2A rs1424954 and rs1424941, we performed TP‐ARMS‐PCR on 600 samples, including 400 peripheral blood samples from preeclamptic and normal women and 200 umbilical cord blood samples from each group of pregnant women.ResultsRegarding rs1424954, only the fetal genotypes were associated with an increased risk of PE in both dominant and recessive inheritance models (OR = 2.88, 95% CI: 1.58–5.25, p = 0.0005; and OR = 2.43, 95% CI: 1.21–4.87, p = 0.012; respectively). For ACVR2A rs1424941variant, both maternal and fetal heterozygote genotypes were associated with PE susceptibility (OR = 1.57, 95% CI: 1.02–2.04, p = 0.04; and OR = 1.90, 95% CI: 1.02–3.54, p = 0.04; respectively).ConclusionThe present study confirmed the role of fetal ACVR2A polymorphisms in PE pathogenesis for the first time. However, replicated studies in diverse ethnicities are necessary to confirm the role of fetal genotype on susceptibility to PE.
Streamlining Diagnosis: Reducing Time for Brain Tumor Detection in Children of an Upper‐Middle‐Income Country
Authors: Dassi Natália , Cappellano Andrea Maria , de Souza Fabiola Isabel Suano , Puccini Rosana Fiorini , da Silva Nasjla Saba , Strufaldi Maria Wany Louzada 
Published: February 2025

ABSTRACTBackgroundDelays in diagnosing pediatric brain tumors are often associated with limited awareness of the signs and symptoms by parents and healthcare professionals, as well as the absence of routine childcare follow‐ups and delays in healthcare system referrals.AimsTo explore opportunities for reducing diagnostic delays, the study assessed the knowledge of pediatric brain tumor signs and symptoms, routine follow‐up care for children, use of the Child Health Book (CHB), and referral intervals of a suspected case to a specialized center.ProcedureThis cross‐sectional study collected data through interviews and virtual questionnaires.ResultsBetween August and November 2023, 200 parents (pediatric and oncology departments) and 147 healthcare professionals (primary and tertiary care) participated. Except for headaches and seizures, the rates of parental recognition of warning signs were below 70%. Physicians in tertiary care demonstrated greater recognition of these warning signs than those in primary care (p = 0.011). Recognition rates among nurses were below 75%. Primary and tertiary care professionals reported referral intervals >1 month in 10%–15% cases. Children routine follow‐up care was reported in both levels. Over 75% of all participants reported that the CHB could be a useful tool for educating about childhood cancer.ConclusionsOur study provides essential insights to improve the early diagnosis of pediatric brain tumors. The findings emphasize the need to strengthen pediatric care follow‐ups and use of CHB by parents and healthcare professionals to raise awareness of warning signs and symptoms, along with a flowchart for timely and accurate referrals to specialized centers.
Anemia and retinopathy of prematurity: A narrative review
Authors: Prasad Minali , Dombrovsky David , Christiansen Stephen P. , Ingolfsland Ellen C. 
Published: February 2025

ABSTRACTRetinopathy of prematurity (ROP) and anemia are often comorbid in preterm and low birth weight infants in the United States. However, the relationship between ROP and anemia in infants is unclear across prospective and retrospective studies due to confounding from other comorbidities of prematurity and variable study designs. Molecular mechanisms that may underlie this association include tissue hypoxia, oxidative stress, inflammation, and the timing of onset of anemia relative to the phase of ROP. Furthermore, maternal or neonatal disruptions in iron homeostasis, leading to either iron deficiency or accumulation, have been associated with ROP. Further studies, including randomized clinical trials, are needed to better elucidate the association between ROP and anemia, as well as the impact of the timing of the onset of anemia.
The Attitudes of the General Student Body Toward Gifted Students and Gifted Education: Attitude Profiles and Predictors
Authors: Jung Jae Yup , Lee Jihyun 
Published: February 2025

ABSTRACTIn this study, an investigation was conducted into the nature of the attitudes of the general student body (comprising all students) toward gifted students and gifted education, along with the predictors of such attitudes. For this purpose, survey data were collected from 400 secondary students enrolled in a faith‐based school system in Australia. Data were analyzed using exploratory factor analysis, latent class analysis, and multiple regression analysis. Among the study findings were: (a) student attitudes toward gifted students and gifted education exist along two dimensions (i.e., support for gifted student adaptations and perceptions of non‐elitism), (b) students may be classified into three groups with distinct attitude profiles that differ from one another along these two dimensions (i.e., strong supporters of gifted students/gifted education, students with neutral attitudes toward gifted students/gifted education and non‐supporters of gifted students/gifted education, comprising 13%, 82%, and 5% of students respectively), and (c) the key predictors of student attitudes are school administrative support, academic impact, respect for authority, knowledge of giftedness and contact with gifted persons. The contributions of the study to the research literature are discussed.
Causal Association Between Multidimensional Plasma Lipid Composition and Pediatric Asthma: A Mendelian Randomization Study
Authors: Xiong Xiaoqin 
Published: February 2025

ABSTRACTBackgroundAsthma is the most common chronic disease among children and poses a major threat to their health. Observational studies have shown lipid disorders in children with asthma. However, it was not possible to determine whether there is a causal link between the two. Therefore, the aim of this study was to assess the causal relationship between serum liposomes and asthma in children.MethodsWe used large‐scale publicly available genome‐wide association study summary statistics to elucidate causal associations between plasma liposomes and children using a two‐sample Mendelian randomization (MR) approach. The IVW method was used as the primary analysis method, and tests such as the Cochran Q test, MR‐Egger intercept, and leave‐one‐out method were utilized to explore whether there was heterogeneity and pleiotropy in the MR results. In addition, Steiger's test and reverse MR analysis were performed to test the directionality of the MR results.ResultsOur MR results identified a causal link between six plasma liposomes and childhood asthma. Among them, negative association between Diacylglycerol (16:0_18:2) (OR = 0.952, 95%CI = 0.913–0.992, p = 0.018), Triacylglycerol (52:4) (OR = 0.949, 95%CI = 0.905–0.994, p = 0.028), Phosphatidylcholine (18:2_20:3) (OR = 0.915, 95%CI = 0.843–0.993, p = 0.034), sterol ester (27:1/22:6) (OR = 0.929, 95% CI = 0.869–0.994, p = 0.031) and childhood asthma. There is a positive association between Phosphatidylcholine (16:0_22:5) (OR = 1.061, 95%CI = 1.006–1.120, p = 0.030), sterol ester (27:1/20:4) (OR = 1.046, 95% CI = 1.021–1.072, p = 0.0003) and pediatric asthma. A series of sensitivity tests also demonstrate the robustness of the results.ConclusionThis MR study identified a causal link between some plasma liposomes and childhood asthma. This will provide new perspectives on the prevention and treatment of childhood asthma in the future.
Nasal Intermittent Positive Pressure Ventilation During Neonatal Endotracheal Intubation: A Randomized Controlled Trial
Authors: Ilhan Ozkan , Celik Kiymet , Ozkan Nurten Zarif , Kocaoglu Ipek , Arayici Sema , Hakan Nilay 
Published: February 2025

ABSTRACTBackgroundThis prospective, multicenter, randomized controlled trial aimed to determine whether the use of nasal intermittent positive pressure ventilation (NIPPV) during neonatal endotracheal intubation increased the rate of successful intubation without physiological instability during all intubation attempts.Material and MethodsIn total, 150 infants were randomly assigned to either an NIPPV or standard care group (n = 75 each). The primary outcome was successful intubation without physiological instability (defined as ≥ 20% decline in the peripheral oxygen saturation [SpO2] from preintubation value or bradycardia with a heart rate < 100 beats/min) during all intubation attempts.ResultsThe mean postmenstrual age of the infants was 32.5 weeks, with a median weight of 1552 g at the time of intubation. The incidence of successful intubation without physiological instability during all intubation attempts was significantly higher in the NIPPV group (64%) than that in the standard care group (42.7%) (p = 0.009). This difference was particularly significant when inexperienced practitioners were involved. In the NIPPV group, the rates of bradycardia (18.7% vs. 41.3%) and severe desaturation (30.7% vs. 49.3%) were significantly lower, whereas the lowest SpO2 (85% vs. 76%) and lowest heart rate (118 vs. 105 beats/min) were significantly higher.ConclusionNIPPV during endotracheal intubation increased the incidence of successful intubation without physiological instability during intubation attempts in neonates while reducing the rate of hypoxia and bradycardia.