bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Transformable Supramolecular Bispecific Cell Engager for Augmenting Natural Killer and T Cell‐Based Cancer Immunotherapy
Authors: Chen Yumiao , Li Wei , Wang Zhongqiu , Yu Yingying , Li Jie , Ding Yinghao , Hu Zhiwen , Liu Qian , Yang Zhimou , Gao Jie 
Published: October 2023

AbstractImmune cells are pivotal in cancer immunotherapy, yet their therapeutic effectiveness is often hampered by limited tumor infiltration and inhibitory tumor microenvironments. An alkaline phosphatase (ALP)‐responsive and transformable supramolecular bis‐specific cell engager (Supra‐BiCE) to harness natural killer (NK)/T cells for effective cancer immunotherapy is introduced here. The Supra‐BiCE, consisting of both SA‐P (a phosphorylated peptide targeting and blocking programmed cell death ligand 1 (PD‐L1)) and SA‐T (a phosphorylated peptide targeting and blocking T cell immunoglobulin and ITIM domain (TIGIT)) is constructed by a simple co‐assembling strategy. Upon intravenous administration, Supra‐BiCE self‐assembles into nanoribbons and interacts with NK/T cells via TIGIT. Notably, these nanoribbons undergo transformation into long nanofibrils within ALP‐overexpressing tumor regions, resulting in enhanced binding affinities of Supra‐BiCE to both PD‐L1 and TIGIT. Consequently, this leads to the accumulation and retention of NK/T cells within tumor regions. Furthermore, the combinatorial blockade of checkpoints by Supra‐BiCE activates infiltrating NK/T cells. Moreover, the adjustable peptide ratio in Supra‐BiCE enables customization for optimal therapeutic effects against distinct tumor types. Particularly, Supra‐BiCE (T:P = 1:3) achieved 98.27% tumor suppression rate against colon carcinoma model. Overall, this study offers a promising tool for engaging NK and T cells for cancer immunotherapy.
A Janus‐ROS Healing System Promoting Infectious Bone Regeneration via Sono‐Epigenetic Modulation
Authors: Ma Liang , Cheng Yu , Feng Xiaobo , Zhang Xiaoguang , Lei Jie , Wang Hongchuan , Xu Yan , Tong Bide , Zhu Dingchao , Wu Di , Zhou Xingyu , Liang Huaizhen , Zhao Kangcheng , Wang Kun , Tan Lei , Zhao Yanli , Yang Cao 
Published: October 2023

AbstractElimination of bacterial infections and simultaneously promoting osteogenic differentiation are highly required for infectious bone diseases. Massive reactive oxygen species (ROS) can damage cells, while low ROS concentrations as a molecular signal can regulate cellular fate. In this study, a Janus‐ROS healing system is developed for infectious bone regeneration. An alendronate (ALN)‐mediated defective metal–organic framework (MOF) sonosensitizer is prepared, which can effectively clear Methicillin‐resistant Staphylococcus aureus (MRSA) infections and promote osteogenic differentiation under differential ultrasonic irradiation. In the presence of zirconium–phosphate coordination, the ALN‐mediated porphyrin‐based MOF (HN25) with a proper defect has great sonodynamic antibacterial efficiency (98.97%, 15 min) and bone‐targeting ability. Notably, under low‐power ultrasound irradiation, HN25 can increase the chromatin accessibility of ossification‐related genes and FOXO1 to promote bone repair through low ROS concentrations. Animal models of paravertebral infection, fracture with infection, and osteomyelitis demonstrate that HN25 successfully realizes the targeted and potent repair of various infectious bone tissues through rapid MRSA elimination, inhibiting osteoclast activity and promoting bone regeneration. The results show that high catalytic efficiency and bioactive MOF can be constructed using pharmaceutical‐mediated defect engineering. The Janus‐ROS treatment is also a promising therapeutic mode for infectious tissue regeneration.
Oxygen‐Independent Synchronized ROS Generation and Hypoxia Prodrug Activation with Z‐Scheme Heterostructure Sonosensitizer
Authors: Chen Yining , Zou Tianshu , Xin Gaoying , Liu Xin , Yang Yunan , Wei Liqi , Zhang Biao , Yu Pengcheng , Ren Yiping , Feng Yanlin , Chen Rui , Cao Fangfang , Chen Xiaoyuan , Cheng Yan 
Published: October 2023

AbstractCombination therapy has emerged as a promising approach for effective tumor treatment. However, the combination of sonodynamic therapy (SDT) and hypoxia‐activated prodrugs (HAPs) has not been explored due to the contradictory requirement of oxygen (O2) for reactive oxygen species (ROS) generation and the necessity to avoid O2 for the activation of HAPs. In this study, this challenge is addressed by developing BiOCl‐Au‐Ag2S Z‐scheme heterostructure nanoparticles loaded with tirapazamine (TPZ) to achieve O2‐independent therapy. These nanoparticles demonstrate efficient electron–hole separation under ultrasound irradiation while maintaining a high redox potential. The generated holes react with water to efficiently produce hydroxyl radicals, while the electrons autonomously activate TPZ, negating the need for O2. In vitro and in vivo assessments validate the effective tumor elimination by these Z‐scheme nanoparticles without disrupting the hypoxic environment. This innovative design overcomes the limitations associated with O2 requirement in SDT and introduces a novel strategy for HAP activation and synergistic therapy between ROS and HAPs‐based therapy.
Stable IL‐2 Nano‐Assembly for Improved Anti‐Tumor Effect
Authors: Liu Yudong , Zeng Wenfeng , Na Wenjing , Wei Xiuli , Song Kai , Wang Youwang , Zhu Ping , Wang Hao , Liang Wei 
Published: October 2023

AbstractInterleukin 2 (IL‐2) is the first approved immune therapeutic drug to treat cancer, however various off‐target effects and intolerable dose‐related toxicities induced by high‐dose intravenous infusion regimens result in a large proportion of patients require dose reduction, preventing the widespread adoption of this treatment. To address these issues, a novel IL‐2 nano‐assembly formulation (nano‐IL‐2) is developed using distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐n‐[methoxy (polyethylene glycol)‐2000] (PEG2000‐DSPE), which is durably stable due to the high binding affinity (10–8 m level) of two components and hardly induces vascular leak or inflamed injury at the injection site. Besides, nano‐IL‐2 exerts excellent solubility, lymph‐targeting property, prolonged and stable serum IL‐2 concentration ranges, and much lower toxicities compared to commercial formulation. Monotherapy of nano‐IL‐2 shows optimal capability to control the growth of murine melanoma and colon cancer. Collectively, the present study provides a novel design strategy for lymph‐targeting IL‐2 formulation which is more suitable for subcutaneous administration with higher safety concern.
Examining narratives around adverse childhood experiences and social determinants of health in media coverage of substance use in two mid‐western cities
Authors: Treves‐Kagan Sarah , Kennedy Katrina , Carrington Makala 
Published: October 2023

AbstractLocal media narratives play an important role in how people interpret and propose solutions for health issues in their community. This research characterized narratives about adverse childhood experiences (ACEs), and/or social determinants of health (SDOH) in media coverage of substance use. Scans covered articles published in the Detroit Free Press and the Cincinnati Enquirer from March 1, 2019 to June 1, 2019 and March 1, 2021 to June 1, 2021. Scans used search terms for opioids and substance use. Included articles were coded and analyzed for narratives about why people use substances, how to prevent substance use, and how ACEs or SDOH relate to substance use. While half of the included articles reported on the overdose epidemic, the most common type of media coverage reported on criminal justice milestones. Other common narratives identified addiction as an illness that should be treated; and over‐prescription of painkillers or the strength of the drugs as causes of substance use disorders. Narratives about SDOH and the primary prevention of ACEs and substance use were limited. Transformational narrative change work can increase support for addressing the root causes of ACEs and substance use. Results suggest this strategy remains largely untapped in the formal media.
Processes for culturally adapting behavioral health interventions for people with refugee backgrounds: A scoping review
Authors: McCleary Jennifer S. , Horn Tonya L. 
Published: October 2023

AbstractAcademic literature supports cultural adaptation (CA) of evidence‐informed interventions to increase accessibility and effectiveness of behavioral health treatment to meet the needs of a culturally diverse society. While several meta‐analyses have shown positive outcomes of CA mental health interventions, there is a need for more information about how theoretical CA models have been applied in practice to meet the cultural and contextual needs of specific groups. This scoping review was conducted to understand how CA models have been applied to adapt evidence‐informed behavioral health interventions for people with refugee backgrounds in resettlement. Eighteen manuscripts were identified and analyzed, resulting in five categories: Reasons for Engaging in CA, Processes of CA, Types of CAs, Resources Needed to Support CA, and Evaluating Adaptation Choices. Only four studies utilized any existing model to guide their adaptation efforts, three of which used CA models. Level of detail regarding CA processes and justification for choices varied considerably among articles. Significant gaps were identified, posing challenges for replication. Although articles reported that adapted interventions were effective, it is unclear which, if any, CA choices contributed to the successful outcomes. Findings indicate a need for emphasis on clear and thorough documentation of CA processes and more rigorous assessment of the impact of adaptation choices.
Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome
Authors: Gorijala Priyanka , Aslam M. Muaaz , Dang Lam‐Ha T. , Xicota L. , Fernandez Maria V. , Sung Yun Ju , Fan Kang‐Hsien , Feingold Eleanor , Surace Ezequiel I. , Chhatwal Jasmeer P , Hom Christy L. ,   Dominantly Inherited Alzheimer Network (DIAN), the Alzheimer's Disease Neuroimaging Initiative (ADNI),   the NIA‐LOAD family study, for the Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators, Hartley Sigan L. , Hassenstab Jason , Perrin Richard J. , Mapstone Mark , Zaman Shahid H , Ances Beau M , Kamboh M. Ilyas , Lee Joseph H , Cruchaga Carlos 
Published: October 2023

AbstractINTRODUCTIONThis study aimed to investigate the influence of the overall Alzheimer's disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and cerebrospinal fluid (CSF) biomarkers.METHODSAD polygenic risk scores (PRS) were tested for association with DS‐related traits.RESULTSThe AD risk PRS was associated with disease status in several cohorts of sporadic late‐ and early‐onset and familial late‐onset AD, but not in familial early‐onset AD or DS. On the other hand, lower DS Mental Status Examination memory scores were associated with higher PRS, independent of intellectual disability and APOE (PRS including APOE, PRSAPOE, p = 2.84 × 10−4; PRS excluding APOE, PRSnonAPOE, p = 1.60 × 10−2). PRSAPOE exhibited significant associations with Aβ42, tTau, pTau, and Aβ42/40 ratio in DS.DISCUSSIONThese data indicate that the AD genetic architecture influences cognitive and CSF phenotypes in DS adults, supporting common pathways that influence memory decline in both traits.Highlights
Examination of the polygenic risk of AD in DS presented here is the first of its kind.
AD PRS influences memory aspects in DS individuals, independently of APOE genotype.
These results point to an overlap between the genes and pathways that leads to AD and those that influence dementia and memory decline in the DS population.
APOE ε4 is linked to DS cognitive decline, expanding cognitive insights in adults.
Fabrication and characterization of 3D printable nanocomposite filament based on cellulose nanocrystals and polylactic acid using ionic liquids
Authors: Haron Gamal Abdalla Suliman , Mahmood Hamayoun , Noh Hilmi Bin , Moniruzzaman Muhammad 
Published: October 2023

AbstractNanocellulose, which is biodegradable and possesses excellent physicochemical properties, has high potential in many applications. However, its intrinsic hydrophilic nature makes it difficult to be used as fillers in most hydrophobic polymer composites. Here, cellulose nanocrystals (CNCs) were successfully prepared using 1‐hexly‐3‐methylimidazolium hydrogen sulfate [Hmim][HSO4] ionic liquid under optimized conditions at 71°C, ultra‐sonication amplitude of 69%, and ultrasonication time of 23 min. The prepared CNCs were surface‐modified using 1‐butyl‐3‐methylimidazolium tetrafluoroborate [Bmim][BF4]. A 3D printable nanocomposite filament containing CNCs embedded in polylactic acid was fabricated via extrusion process at 170°C. The prepared filaments were characterized using universal testing machine, field emission scanning electron microscopy, thermogravimetric analysis, and FTIR. It was shown that CNCs had a diameter and length of 10–24 and 60–400 nm, respectively. It was also found that incorporating 2 wt% of CNCs into the matrix phase increased filaments tensile strength by 2.5% (from 54.59 to 57.35 MPa) due to the plasticization effect of [Bmim][BF4]. The prepared composites exhibited lower activation energies compared to neat PLA due to the small traces of sulfate group on F‐CNC. The mechanical attributes of CNCs/PLA nanocomposites were retained at values comparable to that of fresh PLA and were demonstrated to be 3D printable.
Biology, distribution, and management of invasive South American tomato leafminer, Tuta absoluta (Meyrick) (Lepidoptera; Gelechiidae), in Asia
Authors: Acharya Rajendra , Barman Apurba K. , Sharma Sushant R. , Kafle Lekhnath , Kim Sang‐Mok , Lee Kyeong‐Yeoll 
Published: October 2023

AbstractSouth American tomato leafminer, Tuta absoluta (Meyrick, 1917) (Lepidoptera: Gelechiidae), is native to South America, but is a major invasive and quarantine pest species in Europe, Africa, and Asia. It causes extensive damage of up to 100% yield loss in tomatoes (Solanum lycopersicum) in open and greenhouse conditions. Since its first invasion in Spain in 2006, it has spread rapidly into many countries in the Mediterranean and Western Europe and further invaded Africa and Asia. In Asia, it was first recorded in August 2009 in Turkey and spread to most South and East Asian countries. In this study, we reviewed existing work on the biology and distribution of T. absoluta in Asia, as well as the damage it causes. This review will help to develop efficient management tactics as well as establish quarantine and phytosanitary precautions in uninvaded countries.
Chemical substances and their activities in sea cucumber Apostichopus japonicus: A review
Authors: Lu Chang , Wang Xueyu , Ma Jiahui , Wang Mengtong , Liu Wei , Wang Guangyue , Ding Yuling , Lin Zhe , Li Yong 
Published: October 2023

AbstractApostichopus japonicus, also known as Stichopus japonicus, with medicinal and food homologous figures, is a globally recognized precious ingredient with extremely high nutritional value. There is no relevant review available through literature search, so this article selects the research articles through the keywords “sea cucumber” and “Apostichopus japonicus (Stichopus japonicus)” in six professional databases, such as Wiley, PubMed, ScienceDirect, ACS, Springer, and Web of Science, from 2000 to the present, summarizing the extraction, isolation, and purification methods for the four major categories (polysaccharides, proteins and peptides, saponins, and other components) of the A. japonicus chemical substances and 10 effective biological activities of A. japonicus. Included are anticoagulation, anticancer/antitumor activities, hematopoiesis, regulation of gut microbiota, and immune regulatory activities that correspond to traditional efficacy. Literature support is provided for the development of medicines and functional foods and related aspects that play a leading role in future directions.
Decentralized control for discrete‐time mean‐field systems with multiple controllers of delayed information
Authors: Qi Qingyuan , Liu Zhiqiang , Zhang Qianqian , Lv Xinbei 
Published: October 2023

AbstractIn this paper, the finite horizon asymmetric information linear quadratic (LQ) control problem is investigated for a discrete‐time mean field system. Different from previous works, multiple controllers with different information sets are involved in the mean field system dynamics. The coupling of different controllers makes it quite difficult in finding the optimal control strategy. Fortunately, by applying the Pontryagin's maximum principle, the corresponding decentralized control problem of the finite horizon is investigated. The contributions of this paper can be concluded as follows: For the first time, based on the solution of a group of mean‐field forward and backward stochastic difference equations (MF‐FBSDEs), the necessary and sufficient solvability conditions are derived for the asymmetric information LQ control for the mean field system with multiple controllers. Furthermore, by the use of an innovative orthogonal decomposition approach, the optimal decentralized control strategy is derived, which is based on the solution to a non‐symmetric Riccati‐type equation.
Zur Kenntnis des Siliciummonoxyds. I. Mitteilung. Die Abscheidungsformen des Siliciummonoxyds aus der Dampfphase
Authors: Grube G. , Speidel H. 
Published: October 2023

AbstractBei der Verflüchtigung eines stöchiometrischen Gemenges von Silicium und Siliciumdioxyd werden zwei verschiedene Substanzen niedergeschlagen. Durch chemische Analyse und durch Röntgenuntersuchungen wird fest‐gestellt, daβ das gewonnene braune Produkt ein disproportioniertes Gemenge von Silicium und Siliciumdioxyd darstellt. Das zweite Produkt, eine schwarze glasartige Substanz, ist amorphes Siliciummonoxyd.
Über Siliciummonoxyd
Authors: v. Wartenberg H. 
Published: October 2023

Abstract1. Si und SiO reduzieren saure Fluoridlösungen von Ag, Cu, Hg unter Ausfällen der reinen Metalle, da die sonst die Passivität bedingende SiO2‐Haut beseitigt wird. Diese Reaktion kann zur kalorimetrischen Bestimmung der Bildungswärme von SiO benutzt werden. § 1 bis § 2.2. Die Zusammensetzung des durch Sublimation von SiO2 und Si im Vakuum zu erhaltenden SiO wird festgestellt durch Messung der durch KHO entwickelten H2‐Menge und des ausgefällten Ag in Übereinstimmung mit älteren Analysen von Grube und Speidel. Durch Feststellung des darin weiter enthaltenen SiO2 findet sich die Zusammensetzung: 95% SiO, 4% SiO2, 0,5% Al2O3, 0,5% Na2O. § 3 bis § 6.3. Einige physikalische Eigenschaften des SiO. § 7.4. Die Wärmetönung der Reaktion Si+1/2O2 = SiO wird zu 103±3 kcal gemessen. § 8.5. Durch Heranziehung der von Grube and Speidel gefundenen Bildungswärme von gasförmigem SiO aus dem Reduktionsgleichgewicht von SiO2+H2 wird die Verdampfungswärme von SiO zu 70 kcal berechnet und die Dampfdrucke im Vergleich zu denen von Si geschätzt. § 9.6. Die Dissoziation von SiO2 wird an einem experimentellen Beispiel diskutiert. § 10.
Zersetzungsspannung, Grenzstromdichte und Leitfähigkeit aluminiumchloridhaltiger Schmelzen
Authors: Grothe H. 
Published: October 2023

AbstractDie aus den Polarisationsspannungen ermittelte Zersetzungsspannung von Aluminiumchlorid im Schmelzfluß stimmt gut mit der theoretisch errechneten überein. — Die Leitwerte aluminiumchloridhaltiger Schmelzen werden bestimmt und Formeln zur Vorausberechnung angegeben. — Aus dem Verlauf der Leitwertskurven im System KCl‐AlCl3 wird vermutet, daß der Dissoziationsgrad geschmolzener Salze konstant ist.
Über die Ultraviolett‐Absorption und Konstitution von Tetrazenen aus Aminoguanidinsalzen
Authors: Hofsommer Ruth , Pestemer Max 
Published: October 2023

AbstractVon den bei der Reaktion von Aminoguanidinsalzen mit Nitrit zu Tetrazen auftretenden Zwischenstufen wurden die Absorptionsspektren bestimmt. Aus der Analogie mit Vergleichssubstanzen von chemisch sichergestellter Konstitution wurde die Zuordnung zweier isomerer Endprodukte zu den Formeln eines gestreckten Carbimidazido‐carbimidamido‐tetrazens IV und eines Tetrazyl‐carbamidamido‐tetrazens, in dem ein Ringschluß stattgefunden hat, ermöglicht.
Orientierungseffekte in binären flüssigen Gemischen
Authors: Münster Arnold 
Published: October 2023

AbstractDie thermodynamischen Eigenschaften binärer flüssiger Gemische, die in erster Linie durch Dampfdruck‐messungen und kalorimetrische Messungen ermittelt werden, bieten ein außerordentlich mannigfaltiges Bild. Es sind verschiedene Versuche unternommen worden (auf die wir weiter unten kurz eingehen), diese Ergebnisse mit Hilfe der statistischen Thermodynamik zu erklären. Dabei haben sich jedoch prinzipielle Diskrepanzen zwischen Theorie und Experiment ergeben. Im folgenden soll gezeigt werden, daß diese Diskrepanzen verschwinden, wenn man die gegenseitige Orientierung der Moleküle berücksichtigt, und daß man auf diesem Wege in einigen Fällen auch quantitativ zu einigermaßen befriedigender Übereinstimmung gelangt.
Zusammenhänge zwischen Form und Abscheidungsbedingungen elektrolytisch gewachsener Metallkristalle IV. Fremdstoffeinfluß bei der Entstehung von Blockstrukturen im polykristallinen Niederschlag
Authors: Fischer Hellmut 
Published: October 2023

AbstractEinfluß der Inhibition auf Gestalt und Orientierung der Subindividuen. – Inhibitionsbedingte Wachstumsformen der aus den Subindividuen zusammengesetzten Aggregate. Besonderheiten ihrer Struktur und Orientierung. –Bildung von Zwillingskristallen beim Übergang von der einen in die ander Wachstumsform. – Zusammenhang zwischen Inhibitorempfindlichkeit der Metalle und den von ihnen bevorzugten Wachstumsformen sowie ihre Beziehung zur spezifischen freien Oberflächenenergie, der Atombeweglichkeit und der Sublimationswärme der Metalle.
Ionenhydratation und spezifische Wärme wäßriger Elektrolytlösungen
Authors: Eigen M. , Wicke E. 
Published: October 2023

AbstractIn dem voranstehend beschriebenen Präzisionskalorimeter1) wurden die spezifischen Wärmen wäßriger Lösungen starker Elektrolyte (NaCl, LiBr, MgCl2) von 0–140°C auf 0,05% genau gemessen. Die aus den Meßwerten berechnete scheinbare Molwärme der angegebenen Salze durchläuft unerwarteterweise ein ausgeprägtes Maximum, das in der Nähe von 70°C liegt. Ferner zeigen die Werte eine nahezu lineare Abhängigkeit von der Wurzel aus der Konzentration. Dieser Sachverhalt wird kurz im Zusammenhang mit der Debye‐Hückelschen Theorie diskutiert. Mit Hilfe eines statistisch zu begründenden Ansatzes, der die Grundvorstellung der Euckenschen Theorie der Ionenhydratation2) enthält, gelingt eine befriedigende Darstellung des gefundenen Temperaturverlaufs sowohl der scheinbaren Molwärmen als auch der scheinbaren Molvolumina. Hiernach erklärt sich das Maximum in der scheinbaren Molwärme durch die Überlagerung zweier Effekte: Störung der Assoziationsgleichgewichte der Wasserstruktur durch die gelösten Ionen (sogenannter Lösungsmitteleinfluß, negativer Anteil); Abdissoziation von Wassermolekeln aus den Ionenhydrathüllen mit steigender Temperatur (positiver Anteil). Die quantitative Auswertung führt zu physikalisch sinnvollen Bindungsfestigkeiten der Wassermolekeln in den Hydrathüllen. Dabei ist es zur Erklärung des Maximums wesentlich, diese Hydrathüllen in zwei Bereiche verschiedener Bindungsfestigkeiten (1. und 2. Schicht) zu unterteilen, von denen im hier überstrichenen Temperaturbereich nur die in 2. Schicht gebundenen Wassermolekeln abdissoziieren.