bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fungicides modify pest insect fitness depending on their genotype and population
Authors: Margus Aigi , Saifullah Shahed , Kankare Maaria , Lindström Leena 
Published: October 2023

AbstractFungicides are the most sold pesticide group, with an 8% increase in sales in Europe within the last decade. While adverse short-term fungicide effects on non-target insect species have been reported, the long-term effects and their impact on fitness are unclear. As the effects may depend on both the fungicide and the genetic background of the species, we investigated the effects of the commonly used fungicide, fluazinam, on the Colorado potato beetle's life history traits, and whether the effects were dependent on a previously characterized insecticide resistance mutation (S291G in acetylcholinesterase-2 gene) in different populations. Our findings show that fungicide exposure can have both negative and positive, long-lasting effects on beetles, depending on the parental insecticide resistance status and population. In the Belchow population, individuals carrying resistance mutation had higher survival, but they produced offspring with lower egg-hatching rates. While, in the Vermont population, fungicide exposure increased the body mass and offspring quality in the beetles carrying resistance mutation but did not affect the beetles’ survival. Our results suggest that commonly used fungicides can have both negative and positive effects on pest insects’ life-history, however, their impact may differ depending on the population and parental genetic background.
A study on the effect of bioactive glass and hydroxyapatite-loaded Xanthan dialdehyde-based composite coatings for potential orthopedic applications
Authors: Nawaz Muhammad Haseeb , Aizaz Aqsa , Ropari Abdul Qadir , Shafique Huzaifa , Imran Osama bin , Minhas Badar Zaman , Manzur Jawad , Alqahtani Mohammed S. , Abbas Mohamed , Ur Rehman Muhammad Atiq 
Published: October 2023

AbstractThe most important challenge faced in designing orthopedic devices is to control the leaching of ions from the substrate material, and to prevent biofilm formation. Accordingly, the surgical grade stainless steel (316L SS) was electrophoretically deposited with functional composition of biopolymers and bioceramics. The composite coating consisted of: Bioglass (BG), hydroxyapatite (HA), and lawsone, that were loaded into a polymeric matrix of Xanthan Dialdehyde/Chondroitin Sulfate (XDA/CS). The parameters and final composition for electrophoretic deposition were optimized through trial-and-error approach. The composite coating exhibited significant adhesion strength of “4B” (ASTM D3359) with the substrate, suitable wettability of contact angle 48°, and an optimum average surface roughness of 0.32 µm. Thus, promoting proliferation and attachment of bone-forming cells, transcription factors, and proteins. Fourier transformed infrared spectroscopic analysis revealed a strong polymeric network formation between XDA and CS. scanning electron microscopy and energy dispersive X-ray spectroscopy analysis displayed a homogenous surface with invariable dispersion of HA and BG particles. The adhesion, hydrant behavior, and topography of said coatings was optimal to design orthopedic implant devices. The said coatings exhibited a clear inhibition zone of 21.65 mm and 21.04 mm with no bacterial growth against Staphylococcus aureus (S. Aureus) and Escherichia coli (E. Coli) respectively, confirming the antibacterial potential. Furthermore, the crystals related to calcium (Ca) and HA were seen after 28 days of submersion in simulated body fluid. The corrosion current density, of the above-mentioned coating was minimal as compared to the bare 316L SS substrate. The results infer that XDA/CS/BG/HA/lawsone based composite coating can be a candidate to design coatings for orthopedic implant devices.
Electrical stimulation facilitates NADPH production in pentose phosphate pathway and exerts an anti-inflammatory effect in macrophages
Authors: Uemura Mikiko , Maeshige Noriaki , Yamaguchi Atomu , Ma Xiaoqi , Matsuda Mami , Nishimura Yuya , Hasunuma Tomohisa , Inoue Taketo , Yan Jiawei , Wang Ji , Kondo Hiroyo , Fujino Hidemi 
Published: October 2023

AbstractMacrophages play an important role as effector cells in innate immune system. Meanwhile, macrophages activated in a pro-inflammatory direction alter intracellular metabolism and damage intact tissues by increasing reactive oxygen species (ROS). Electrical stimulation (ES), a predominant physical agent to control metabolism in cells and tissues, has been reported to exert anti-inflammatory effect on immune cells. However, the mechanism underlying the anti-inflammatory effects by ES is unknown. This study aimed to investigate the effect of ES on metabolism in glycolytic-tricarboxylic acid cycle (TCA) cycle and inflammatory responses in macrophages. ES was performed on bone marrow-derived macrophages and followed by a stimulation with LPS. The inflammatory cytokine expression levels were analyzed by real-time polymerase chain reaction and ELISA. ROS production was analyzed by CellRox Green Reagent and metabolites by capillary electrophoresis-mass spectrometry. As a result, ES significantly reduced proinflammatory cytokine expression levels and ROS generation compared to the LPS group and increased glucose-1-phosphate, a metabolite of glycogen. ES also increased intermediate metabolites of the pentose phosphate pathway (PPP); ribulose-5-phosphate, rebose-5 phosphate, and nicotinamide adenine dinucleotide phosphate, a key factor of cellular antioxidation systems, as well as α-Ketoglutarate, an anti-oxidative metabolite in the TCA cycle. Our findings imply that ES enhanced NADPH production with enhancement of PPP, and also decreased oxidative stress and inflammatory responses in macrophages.
Dogs outperform cats both in their testability and relying on human pointing gestures: a comparative study
Authors: Salamon Attila , Uccheddu Stefania , Csepregi Melitta , Miklósi Ádám , Gácsi Márta 
Published: October 2023

AbstractThe dog is a so far unique species to study interspecific communication and a promising evolutionary model for preverbal human communication. Recently cats were reported to show some similar skills to dogs. Here we directly compared both the testability and the success of companion dogs and cats in relying on human distal pointing gestures. Due to differences in their domestication, social and ecological background, and developmental processes, we expected better performance from dogs compared to cats. Using an object-choice task, cats made considerably fewer choices than dogs in the laboratory environment, and their tendency to make a choice declined during trials. They were slightly more testable at home, where their willingness to choose did not decrease over time. Dogs made more successful choices than cats, both at the group and individual level, irrespective of the type of the pointing gesture. Older cats were more successful. Despite the two species’ rather similar role nowadays as human companions, our results support previous findings suggesting that, compared to the dog, the cat is a less ideal model to study some human communicative abilities in a laboratory environment.
Sustainable approach of La doped CuFe2O4 nanomaterial for electrochemical lead and paracetamol sensing action with multiple applications
Authors: Giridhar Meenakshi , Manjunath B. C. , Surendra B. S. , Harish K. N. , Prashantha S. C. , Kiran T. , Uma B. , Murthy H. C. Ananda 
Published: October 2023

AbstractThis present research aimed to investigate the novel applications of synthesized La doped CuFe2O4 nanomaterial (LCF NMs) using renewable bio-fuel (Aegle Marmelos extract) by combustion process. The sensor applications were accomplished by modified electrode using LCF NMs with graphite powder and examined its excellent sensing action towards heavy metal (Lead content) and drug chemical (Paracetamol) substances. The thermodynamics of redox potential and super-capacitor behavior of LCF NMs were investigated through Cyclic Voltametric (CV) and Electrochemical Impedance Spectral (EIS) methods under specific conditions at scan rate of 1 to 5 mV/s. The heterogeneous photo-catalytic process of prepared NMs on Fast orange Red (FOR) dye-decolouration was investigated and noted its excellent degradation (91.7%) at 90 min using 20 ppm of dye solution and 40 mg of synthesized samples under Sun-light irradiation. Further, the antibacterial activity of synthesized NMs is investigated against various strains of gram positive (Bacillus subtillis) and gram negative bacteria (Pseudomonas aeruginosa), which confirms that the LCF NMs have higher activity towards gram positive bacteria with an average inhibition zone of 19 mm. This synthesized LCF NMs is a multi-functional material with stable and eco-friendly materials.
Rationalizing general limitations in assessing and comparing methods for compound potency prediction
Authors: Janela Tiago , Bajorath Jürgen 
Published: October 2023

AbstractCompound potency predictions play a major role in computational drug discovery. Predictive methods are typically evaluated and compared in benchmark calculations that are widely applied. Previous studies have revealed intrinsic limitations of potency prediction benchmarks including very similar performance of increasingly complex machine learning methods and simple controls and narrow error margins separating machine learning from randomized predictions. However, origins of these limitations are currently unknown. We have carried out an in-depth analysis of potential reasons leading to artificial outcomes of potency predictions using different methods. Potency predictions on activity classes typically used in benchmark settings were found to be determined by compounds with intermediate potency close to median values of the compound data sets. The potency of these compounds was consistently predicted with high accuracy, without the need for learning, which dominated the results of benchmark calculations, regardless of the activity classes used. Taken together, our findings provide a clear rationale for general limitations of compound potency benchmark predictions and a basis for the design of alternative test systems for methodological comparisons.
Mortality and toxicity of a commercial formulation of cypermethrin in Physalaemus gracilis tadpoles
Authors: Macagnan Natani , Rutkoski Camila Fatima , Folador Alexandre , Skovronski Vrandrieli Jucieli , Müller Caroline , Hartmann Paulo Afonso , Hartmann Marilia 
Published: October 2023

AbstractThis study evaluated the lethal, sublethal, and toxic of a commercial formulation of cypermethrin in the anuran species Physalaemus gracilis. In the acute test, concentrations of 100–800 μg L−1 were tested over 96 h. In the chronic test, cypermethrin concentrations recorded in nature (1, 3, 6, and 20 μg L−1) were tested for mortality and then used for the micronucleus test and erythrocyte nuclear abnormalities over a 7-days period. The LC50 determined for P. gracilis for the commercial cypermethrin formulation was 273.41 μg L−1. In the chronic test, a mortality of more than 50% was observed at the highest concentration (20 μg L−1), as it caused half of the tadpoles studied to die. The micronucleus test showed significant results at concentrations of 6 and 20 μg L−1 and recorded the presence of several nuclear abnormalities, indicating the genotoxic potential of the commercial cypermethrin formulation for P. gracilis. Cypermethrin presented a high risk to the species, indicating that it has the potential to cause several problems in the short and long term and to affect the dynamics of this ecosystem. Therefore, it can be concluded that the commercial formulation of cypermethrin had toxicological effects on P. gracilis.
Enhanced photocatalytic performance of milkvetch-derived biochar via ZnO–Ce nanoparticle decoration for reactive blue 19 dye removal
Authors: Jahani Fatemeh , Maleki Basir , Mansouri Mohsen , Noorimotlagh Zahra , Mirzaee Seyyed Abbas 
Published: October 2023

AbstractIn this research, the photocatalytic removal of reactive blue 19 (RB19) dye is investigated employing zinc oxide/cerium (ZnO@Ce) nanoparticles decorated with biochar under LED irradiation. Synthesis of ZnO@Ce nanoparticles decorated with biochar was performed utilizing the co-precipitation procedure and, then, the texture and morphology of the fabricated nanocomposite were analyzed using energy dispersive X-ray (EDX), field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRD), transmission electron microscopy (TEM), Brunauer–Emmett–Teller (BET), and Fourier transform infrared (FTIR) spectroscopy techniques. Moreover, FE-SEM images demonstrate that ZnO–Ce nanoparticles were successfully decorated on the surface of biochar. The specific surface areas of biochar and biochar/ZnO–Ce were 519.75 and 636.52 m2/g, respectively. To achieve the maximum yield in the removal of RB19 dye, the effects of operating variables including dye concentration, LED lamp power, biochar@ZnO–Ce catalyst dose, pH and H2O2 dose were explored. Besides, the maximum percentage of RB19 dye removal was 96.47% under optimal conditions, i.e. catalyst dosage of 100 mg, H2O2 dosage of 1 mL, pH of 9, initial dye concentration of 5 ppm, LED power of 50 W, and reaction time of 140 min. Furthermore, the kinetic analysis reveals that the removal of RB19 dye follows the pseudo-first order kinetic model, with calculated values of a reaction rate constant of 0.045 min−1 and a correlation coefficient of R2 = 0.99, respectively. Moreover, the reusability and recyclability of biochar@ZnO/Ce nanocatalyst was promising over five runs, with only a 6.08% decrease in RB19 dye removal efficiency. Therefore, it can be concluded that the biochar @ZnO/Ce photocatalyst can be promisingly applied for the removal of azo dyes in aqueous solutions.
Lighting-environment-adjustable block-type 3D indoor PV for wireless sensor communication
Authors: Sim Yeon Hyang , Hwang Jung-Hyun , Yun Min Ju , Lee Kyoungho , Lee Dong Yoon , Cha Seung I. 
Published: October 2023

AbstractDemand is increasing for photovoltaics (PVs) as a result of the development of the Internet of Things and edge computing technologies. As the lighting environment is different for the applications, thus, PVs must be adjustable to various light environments in which systems are installed. PVs should therefore be capable of easily changing their morphology without damaging the cells. To address this problem, in this work, a three-dimensional (3D) structure that increases power output under omnidirectional light was applied to a crystalline silicon solar cell array using a block-type method. The resultant block-type 3D indoor PV could operate a Bluetooth low-energy module in conjunction with a power management integrated circuit when the illuminance was 532 lx and 1620 lx and each PV installation area was 129.9cm2 and 32.48 cm2 respectively.
Body size awareness matters when dogs decide whether to detour an obstacle or opt for a shortcut
Authors: Pongrácz Péter , Dobos Petra , Faragó Tamás , Kubinyi Enikő , Lenkei Rita 
Published: October 2023

AbstractBody-awareness is one of the fundamental modules of self-representation. We investigated how body-awareness could contribute to dogs' decision making in a novel spatial problem where multiple solutions are possible. Family dogs (N = 68) had to obtain a treat from behind a transparent fence. They had two options: either detour around the fence (7 m), or take a shortcut through a doorway (2 m). We had three conditions: small door open, large door open, and doors closed. Our results indicated that dogs assess the size of the doorway, and if they find it too small, they decide to detour instead, while in the case of the open large door, they rather opted for the shortcut without hesitation. Shorter headed dogs tended to choose open doors more often, while longer headed dogs rather chose detours, probably because of their better peripheral vision. While body size awareness did not manifest differently in dogs with short or long heads, we showed for the first time a connection between head shape and physical cognition in dogs. We showed that dogs rely on their body-awareness in a naturalistic setting where multiple solutions exist simultaneously. Dogs make decisions without lengthy trial-and-error learning and choose between options based on their body-awareness.
Electrolyte design for lithium-ion batteries with a cobalt-free cathode and silicon oxide anode
Authors: Ko Seongjae , Han Xiao , Shimada Tatau , Takenaka Norio , Yamada Yuki , Yamada Atsuo 
Published: October 2023

AbstractLithium-ion batteries (LIBs) to power electric vehicles play an increasingly important role in the transition to a carbon neutral transportation system. However, at present the chemistry of LIBs requires, among other elements, cobalt (Co), which will probably become scarce over time in addition to posing supply chain risks related to its single source, human rights and mining practices. To address this problem, we construct a LIB pairing a Co-free cathode with a silicon suboxide (SiOx) anode that possesses a high cut-off voltage of 4.9 V and sustains unprecedented 1,000 cycles. Underlying this favourable electrode combination is a rational electrolyte design based on 3.4 M LiFSI/FEMC featuring a shifted potential, which serves to aid formation of robust passivation layers on the anode and promote electrolyte stability against both reductive and oxidative degradations. Our electrolyte formulation offers a pathway towards both sustainable and high-performing LIBs, while the concept could be applied to other electrochemical energy technologies.
Output feedback stochastic MPC for tracking control of quadrotors with disturbances
Authors: Xue Ruochen , Dai Li , Wang Peizhan , Sun Zhongqi , Xia Yuanqing 
Published: October 2023

AbstractIn this paper, the trajectory tracking problem of controlling a constrained quadrotor with unmeasurable system states in an environment with stochastic wind‐gust disturbance is considered. The mathematical model of the quadrotor is divided into the translational system and the rotational system, while only the measurement output of the quadrotor can be accessed. A new output‐based control method is developed for solving this problem. In the translational control system, an output feedback stochastic model predictive control (MPC) algorithm is proposed to generate the optimal control sequence with less conservativeness, by taking into account the information on the distribution of the disturbances and the uncertainty resulting from the attitude tracking error. The closed‐loop probabilistic constraints satisfaction, the recursive feasibility and the stability of the algorithm are further proved. In the rotational system, the active disturbance rejection control (ADRC) method to estimate and compensate for external disturbances is leveraged and robust control for attitude tracking is accomplished. The convergence of the disturbance estimator and the stability proof are provided. Finally, the robustness and effectiveness of the proposed control strategy are verified by an illustrative example.
A review of intelligent ship marine object detection based on RGB camera
Authors: Yang Defu , Solihin Mahmud Iwan , Zhao Yawen , Yao Benchun , Chen Chaoran , Cai Bingyu , Machmudah Affiani 
Published: October 2023

AbstractThe article presents a comprehensive summary of Intelligent Ship Marine Object Detection (ISMOD) based on the RGB Camera. Marine object detection plays a pivotal role in enabling intelligent ships to acquire crucial data and security assurances for autonomous navigation. Among the various detection sensors, the RGB Camera is an informative and cost‐effective tool with a wide range of civil applications. In the beginning, the ISMOD metrics based on the RGB camera is analyzed from three significant aspects, namely accuracy, speed, and robustness. Subsequently, the latest research status and comparative overview are presented, encompassing three mainstream detection methods: traditional detection, deep learning detection, and sensor fusion detection. Finally, the existing challenges of ISMOD are discussed and future development trends are recommended. The results demonstrate that forthcoming development will predominantly concentrate on deep learning approaches, complemented by other techniques. It is imperative to advance detection performance in domains such as deep fusion, multi‐feature extraction, multi‐fusion technology, and lightweight detection architecture.
A Lethal Late Complication: Aortoesophageal Fistula after TEVAR
Authors: Karaca Sedat , Yalic İslam , Bulut Barkın , Engin Yaprak , Posacıoğlu Hakan 
Published: October 2023

AbstractThoracic endovascular aortic repair (TEVAR) has been performed in the treatment of thoracic aortic disease since the mid-1990s. Complications associated with TEVAR are increasing rapidly due to its widespread use. One of these complications is late lethal aortoesophageal fistula (AEF). The aim of this study was to describe the diagnosis of AEF in a 64-year-old woman 8 months after TEVAR. The AEF was diagnosed on a computed tomography angiography with oral and intravenous contrast. The patient underwent open surgical repair and died of sepsis 12 days after surgery.
Contributions of young people in dialogue with scientific evidence on sexual consent
Authors: Duque Elena , Cañaveras Paula , Racionero-Plaza Sandra , Ortuño Blas 
Published: October 2023

AbstractScientific research increasingly underlines the importance of a community science focus in research. It explains the importance of engaging young people in scientific research and the consequences of this in improving science. However, there is less literature addressing how this dialogue with scientific evidence also influences research participants’ empowerment in seeking concrete solutions and even proposing and/or transforming current interactions they have in different environments. This research aims to shed light on the theory and methodology procedure that enables young people aged 18–25 to be engaged in a scientific dialogue on sexual consent that challenges their own realities. In the framework of the CONSENT project (PID2019-110466RB-I00), a questionnaire script was co-created by the researchers, young people, and the project advisory committee, and later 50 daily life stories and 7 focus groups were conducted. Results show how, as the dialogue and access to scientific evidence progressed, ideas that influence the concrete understanding of consent arise, which is a previous requirement to promote spaces free of coercion and favour their freedom and that of the people with whom they relate. The implications of these results are twofold; on the one hand, the results generate a social impact on the lives of these young people and the people they meet, while on the other hand, their participation implies improved information that should be incorporated into sexual consent awareness campaigns.