bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reframing stigma in Tourette syndrome: an updated scoping review
Authors: Pring Kelly , Malli Melina , Hardy Brandy W. , Rapp Stephen R. , Storch Eric A. , Mink Jonathan W. , Martindale Jaclyn M. 
Published: December 2023

Abstract
Persistent tic disorders (PTD) such as Tourette’s syndrome (TS) are common childhood-onset neurodevelopmental disorders. Stigmatization of individuals with these disorders remains an ongoing problem. The purpose of this scoping review is to serve as an updated review of the research regarding stigmatization in youth with PTD since the publication of the original systematic review about this topic in 2016. The electronic databases Embase, Web of Science, PubMed, PsycINFO, and CINAHL were searched. Of the 4751 initial articles screened after removing duplications, 47 studies met the inclusion criteria. The studies were examined under the social–ecological stigmatization model, which helps categorize stigmatization into individual, interpersonal, community, and structural levels and serves as a broader definition of stigmatization than the previous systematic review. On the individual level, youth with PTD had lower self-esteem than peers, often leading to fear of future stigmatization, avoidant behaviors, and self-stigmatization. They also experienced higher rates of bullying and other forms of abuse than peers at the interpersonal level. At the community level, youth with PTD faced discriminatory environments in school and work and limited availability of community services and healthcare access. At the structural level, knowledge about PTD was limited in the general population, often about the limited portrayals of PTD in the media. We hope that the broader scope of this review serves to help inform future efforts to decrease the stigmatization faced by this group.
Quantification of hydrogen bond energy based on equations using spectroscopic, structural, QTAIM-based, and NBO-based descriptors which calibrated by the molecular tailoring approach
Authors: Afonin Andrei V. , Rusinska-Roszak Danuta 
Published: December 2023

Abstract
Context
Hydrogen bonds critically influence the structure and properties of both organic molecules and biomolecules, as well as supramolecular assemblies. For this reason, the development and elaboration of methods for quantitative assessment of hydrogen bond energy is an urgent challenge. In this study, using a large series of hydroxycarbonyl aliphatic compounds with the O‒H···O = C intramolecular hydrogen bond, a bank of hydrogen bond descriptors was created, including spectroscopic, structural, QTAIM-based, and NBO-based parameters. It was shown that the O‒H vibration frequency, OH chemical shift as the spectroscopic descriptors, the O···H hydrogen bond length, O···O distance, and O‒H covalent bond length as the structural descriptors, the electron density and its Laplacian, electron potential energy density in the hydrogen bond critical point, the electron density at the ring critical point as the QTAIM-based descriptors change in a correlated manner. The same correlation is found in change of the charge transfer energy through a hydrogen bond, the occupancy of the O‒H bond antibonding orbital, the Wiberg indices of the O···H hydrogen bond, and the O‒H covalent bond, as well as the polarization of the O‒H bond, which are the NBO-based descriptors. It was also recognized that the specified descriptors from the spectroscopic, structural, QTAIM-based, and NBO-based categories are functionally related to the values of intramolecular hydrogen bond energy, quantified via the molecular tailoring approach. This allowed one to obtain a system of equations for quantitative estimation of intramolecular hydrogen bond energy based on the spectroscopic, structural, QTAIM, and NBO descriptors, which makes such quantification more dependable and reliable.

Methods
To obtain the spectroscopic descriptors, the vibrational spectra and shielding constants were calculated using the GIAO method. Structural descriptors were obtained for the equilibrium geometry of molecules, calculated at the MP2(FC)/6–311 +  + (2d,2p) level using the Gaussian 09 program. The QTAIM-based descriptors were calculated using the AIMAll program within the framework of the quantum theory “Atoms in Molecules.” The NBO-based descriptors were calculated using the NBO 3.1 program implemented into Gaussian 09. To quantify the energy of intramolecular hydrogen bonds, molecular fragmentation was used within the molecular tailoring approach.
The influence of viscose fibre properties on the absorbency of feminine hygiene tampons: the pivotal role of cross-sectional geometry
Authors: Harter T. , Wagner A. , Wolfbauer A. , Bernt I. , Mautner A. , Kriechbaum M. , Nevosad A. , Hirn U. 
Published: December 2023

Abstract
Feminine hygiene products, used by millions of women worldwide on a daily basis, come in various forms. Among them, tampons are a prominent type that aims to absorb menstrual blood directly in the vagina. However, the underlying mechanisms governing liquid absorption in tampons have received limited research attention and remain poorly understood. This study aims to investigate these mechanisms by examining the two main types of viscose fibres used in tampons and their effects when employed in tampon production. The sole distinction between the fibre types lies in their geometric shape—round or trilobal—while all other fibre parameters remain constant. To explore these mechanisms, tampon proxies made from these fibres were created and subjected to tests measuring liquid absorption. In addition, a novel method employing infrared thermography was utilized to infer the stored energy within the compressed tampon. Furthermore, individual fibres were characterised for chemical composition, surface properties, fine structure, liquid interaction, mechanical parameters, and friction behaviour. The results revealed that trilobal fibres exhibited higher tampon absorbency compared to their round counterparts, despite sharing similar chemical composition and comparable mechanical characteristics. This disparity can be attributed to the greater specific surface area of trilobal fibres, leading to enhanced liquid uptake through fibre swelling. However, single fibre swelling only accounted for a minor fraction of the total liquid absorbency of a tampon. The most influential fibre parameter was the geometric shape, as trilobal fibres facilitated the construction and maintenance of a bulkier network with increased available volume for liquid absorption.

Graphic abstract
A simple way to integrate distributed storage into a wholesale electricity market
Authors: Lamadrid Alberto J. , Lu Hao , Mount Timothy D. 
Published: December 2023

AbstractCurrent plans to decarbonize the electric supply system imply that the generation from wind and solar sources will grow substantially. This growth will increase the uncertainty of system operations due to the inherent variability of these renewable sources, and as a result, more reserve capacity will be required to provide the ramping (flexibility) needed for reliable operations. This paper assumes that all of the increased uncertainty comes from wind farms on the grid, and it shows how distributed storage managed locally by aggregators can provide the ramping needed without introducing a separate market for flexibility. This can be accomplished when the aggregators minimize the expected daily cost of the energy purchased from the grid for their customers by submitting optimal bids into the wholesale market with high and low price thresholds for discharging and charging the storage. This model is illustrated using a stochastic multi-period security constrained optimal power flow together with realistic data for a reduction of the network in the Northeast Power Coordinating Council region of the United States. The results show that the bidding strategy for distributed storage provides ramping to the grid just as effectively as storage managed by a system operator.
A virus from Aspergillus cibarius with features of alpha- and betachrysoviruses
Authors: Lutz Tobias , Langer Gitta Jutta , Heinze Cornelia 
Published: December 2023

AbstractFrom the ascomycete Aspergillus cibarius strain NW-FVA 2590, which was originally isolated from a root, associated with stem collar necrosis of Fraxinus excelsior L., a novel virus was isolated and characterized. Its genome is encoded on three monocistronic dsRNA segments ranging from 3683 bp (dsRNA 1) over 3093 (dsRNA 2) to 2902 bp (dsRNA 3), which are packed in isometric particles of around 35 nm. While the viral RdRp (P1) is encoded on segment 1, protein sequencing showed that two more structural proteins are present which are translated from dsRNA 2 (P2) and dsRNA 3 (P3) and possibly form the viral capsid. Additionally, P2 and P3 may undergo posttranslational modifications since the detected proteins bands deviated from the calculated sizes. Due to its phylogenetic position, the novel virus was grouped in the family of Chrysoviridae and was tentatively denominated as Aspergillus cibarius chrysovirus 1 (AcCV1). Due to its composition, biological properties and phylogenetic position, distant from the genera Alphachrysovirus and Betachrysovirus, we suggest to position AcCV1 in a proposed genus “Gammachrysovirus”.
Intracellular iron accumulation facilitates mycobacterial infection in old mouse macrophages
Authors: Kotey Stephen K. , Tan Xuejuan , Fleming Owen , Kasiraju Ramakrishnama Raju , Dagnell Audrey L. , Van Pelt Kyle N. , Rogers Janet , Hartson Steven D. , Thadathil Nidheesh , Selvarani Ramasamy , Ranjit Rojina , Logan Sreemathi , Deepa Sathyaseelan S. , Richardson Arlan , Cheng Yong 
Published: December 2023

AbstractAging has a significant impact on the immune system, leading to a gradual decline in immune function and changes in the body’s ability to respond to bacterial infections. Non-tuberculous mycobacteria (NTM), also known as atypical mycobacteria or environmental mycobacteria, are commonly found in soil, water, and various environmental sources. While many NTM species are considered opportunistic pathogens, some can cause significant infections, particularly in individuals with compromised immune systems, such as older individuals. When mycobacteria enter the body, macrophages are among the first immune cells to encounter them and attempt to engulf mycobacteria through a process called phagocytosis. Some NTM species, including Mycobacterium avium (M. avium) can survive and replicate within macrophages. However, little is known about the interaction between NTM and macrophages in older individuals. In this study, we investigated the response of bone marrow–derived macrophage (BMMs) isolated from young (5 months) and old (25 months) mice to M. avium serotype 4, one of the main NTM species in patients with pulmonary NTM diseases. Our results demonstrated that BMMs from old mice have an increased level of intracellular iron and are more susceptible to M. avium serotype 4 infection compared to BMMs from young mice. The whole-cell proteomic analysis indicated a dysregulated expression of iron homeostasis–associated proteins in old BMMs regardless of mycobacterial infection. Deferoxamine, an iron chelator, significantly rescued mycobacterial killing and phagolysosome maturation in BMMs from old mice. Therefore, our data for the first time indicate that an intracellular iron accumulation improves NTM survival within macrophages from old mice and suggest a potential application of iron-chelating drugs as a host-directed therapy for pulmonary NTM infection in older individuals.
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity
Authors: Gao Chenhao , Shang Junkui , Sun Zhengyu , Xia Mingrong , Gao Dandan , Sun Ruihua , Li Wei , Wang Fengyu , Zhang Jiewen 
Published: December 2023

AbstractAlzheimer’s disease (AD) is an age-related progressive neurodegenerative disease, and approximately 10% of AD cases are early-onset familial AD (EOFAD), which is mainly linked to point mutations in genes encoding presenilins (PS1 and PS2). Mutations in PS2 are extremely rare and have not received enough attention. Recently, studies have found that Rho GTPase activity is closely related to the pathogenesis of AD. In this study, we used transcriptome sequencing in PS2 siRNA-transfected SH-SY5Y cells and found a group of differentially expressed genes (DEGs) related to the regulation of GTPase activity. Among those DEGs, the most significantly downregulated was Rho guanine nucleotide exchange factor 5 (ARHGEF5). GTPase activity in PS2 siRNA-transfected cells was significantly decreased. Then, we found that the expression of ARHGEF5 and the GTPase activity of Mitochondrial Rho GTPase 2 (Miro2) in PS2 D439A mutant SH-SY5Y cells were significantly decreased. We found for the first time that PS2 can bind to Miro2, and the PS2 D439A mutation reduced the binding between PS2 and Miro2, reduced the expression of Miro2, and resulted in an imbalance in mitochondrial fusion/fission dynamics. In conclusion, PS2 gene knockdown may participate in the pathogenesis of AD through the regulation of GTPase activity. The imbalance in mitochondrial dynamics mediated by the PS2 D439A mutation through regulation of the expression and GTPase activity of Miro2 may be a potential pathogenic mechanism of AD.
Accuracy of small area mortality prediction methods: evidence from Poland
Authors: Orwat-Acedańska Agnieszka 
Published: December 2023

AbstractWe investigate the forecasting accuracy of several simple methods for predicting mortality in small regional areas in Poland. We focus on methods that scale country-level forecasts appropriately and, therefore, can be used by official statistical agencies to improve population projections. We examine data from 379 sub-NUTS-3 districts in Poland for the period 2006–2019, divided into three subperiods. The first period is treated as the training sample and the latter two the testing subperiods. The mortality surface method delivers the most accurate forecasts of the mortality profiles whereas using the district-level standardized mortality rates (SMR) calculated for several broad age groups to scale the country-level mortality forecasts gives the best life expectancy at birth predictions. The latter approach is far better than using the NUTS-2-based standardized mortality rate (SMR), as practiced by the Polish statistical agency. For single age-groups predictions, the SMR-based methods deliver relatively accurate forecasts for young cohorts, but their forecasting accuracy deteriorates significantly with age.
Evaluation of the Versatility of a Traffic Anomaly Detection Method during Heavy Rainfall
Authors: Kawasaki Yosuke , Hirata Kensuke , Ootake Hiroshi 
Published: December 2023

AbstractDuring heavy rains, traffic monitoring is limited, as the affected areas are monitored by reporting and patrolling. In this study, a method for detecting traffic anomalies during heavy rainfall events was established, and a model that uses probe vehicle data to detect traffic anomalies during a disaster (an event in which vehicles make U-turns in front of a damaged area) was proposed. In addition, a parameter calibration method was developed for the model using past disaster-related data. The generalizability of the calibrated model was evaluated by applying it to other disasters. According to the results, the proposed model exhibited good generalizability.
Saccade Induced Retrieval Enhancement, Handedness & the Retrieval of Central & Peripheral Details in Eyewitness Memory
Authors: Parker Andrew , Parkin Adam , Dagnall Neil 
Published: December 2023

AbstractTwo experiments are presented that investigated the effects of horizontal saccadic eye movements and handedness on eyewitness memory for central and peripheral information. In both experiments, participants viewed a short video depicting a bank robbery and episodic memory was tested after a short delay. Experiment 1 used recognition memory and found an interaction between eye movement, handedness and type of information recalled. This indicated that eye movements enhanced memory to a greater extent for peripheral information for individuals classified as consistently handed. Experiment 2 used free-recall and found eye movement enhancement effects of similar magnitude for central and peripheral items. A similar pattern of eye movement effects was observed for both consistent and inconsistent-handed individuals. Inconsistent handers also had superior memory overall. The results are discussed in terms of theoretical accounts of eye movement effects and implications for the enhancement of eyewitness memory.
Review on mechanical and functional properties of refractory high-entropy alloy films by magnetron sputtering
Authors: El Garah Mohamed , Soubane Driss , Sanchette Frederic 
Published: December 2023

AbstractRefractory high-entropy films (RHEFs), as multi-component materials, have garnered significant attention due to their potential use in high-temperature applications. RHEFs are endowed with unique microstructural and functional properties due to the use of refractory elements. In this review, we examine the recent state of research on RHEFs deposited by the magnetron sputtering technique. The microstructure of RHEFs has been analyzed/explored and the mechanical properties as well as the main hardening mechanisms of these films are discussed. Furthermore, functional properties such as resistance to corrosion and wear, electrical and irradiation performances, and high-temperature oxidation were evaluated. RHEFs can meet market demand in the field of engineering materials. However, many challenges, such as low ductility at room temperature, remain to be overcome. This review provides an overview of the strengths and weaknesses of RHEFs produced using magnetron sputtering.
Safety practices and occupational hazards of the additive manufacturing of high entropy alloys
Authors: Modupeola Dada , Popoola Patricia 
Published: December 2023

AbstractAdditive manufacturing (AM), often known as 3D printing, is becoming more popular in contemporary sectors for product development, prototyping, and the production of complicated, precise components. This technique provides benefits such as shorter production cycles, lower tooling costs, waste reduction, simpler customization, and new distribution options. AM has been applied in automotive, aerospace, medical devices, construction, and biomedical applications. High-entropy alloys (HEAs) are gaining research interest in materials science and engineering due to their multiple principal elements and potential for numerous compositions. These alloys present fundamental issues that challenge conventional theories, models, and methods. Recent studies in HEAs address phase formation, novel properties, and structural and functional potential, making HEAs promising candidates for several applications. Layer-by-layer construction of intricate structures using high-entropy alloys requires melting metal powders with lasers or other heat sources. However, AM in high-entropy alloys poses unique safety issues. This review's ultimate goal is to raise awareness of the occupational hazards associated with additive manufacturing and provide practical solutions for safe and efficient operations. It serves as an interesting call to action for employers, workers, and regulators to prioritize safety practices in the growing field of additive manufacturing of high-entropy alloys, ultimately leading to a safer and more sustainable workplace.
Develop quantitative FRET (qFRET) technology as a high-throughput universal assay platform for basic quantitative biomedical and translational research and development
Authors: Liao Jiayu 
Published: December 2023

AbstractProtein–protein interactions and enzyme-catalyzed reactions are the fundamental processes in life, and the quantification and manipulation, kinetics determination, and ether activation or inhibition of these processes are critical for fully understanding physiological processes and discovering new medicine. Various methodologies and technologies have been developed to determine the parameters of these biological and medical processes. However, due to the extreme complexity of these processes, current methods and technologies can only determine one or a few parameters. The recent development of quantitative Förster resonance energy transfer (qFRET) methodology combined with technology aims to establish a high-throughput assay platform to determine protein interaction affinity, enzymatic kinetics, high-throughput screening, and pharmacological parameters using one assay platform. The FRET assay is widely used in biological and biomedical research in vitro and in vivo and provides high-sensitivity measurement in real time. Extensive efforts have been made to develop the FRET assay into a quantitative assay to determine protein–protein interaction affinity and enzymatic kinetics in the past. However, the progress has been challenging due to complicated FRET signal analysis and translational hurdles. The recent qFRET analysis utilizes cross-wavelength correlation coefficiency to dissect the sensitized FRET signal from the total fluorescence signal, which then is used for various biochemical and pharmacological parameter determination, such as KD, Kcat, KM, Ki, IC50, and product inhibition kinetics parameters. The qFRET-based biochemical and pharmacological parameter assays and qFRET-based screenings are conducted in 384-well plates in a high-throughput assay mode. Therefore, the qFRET assay platform can provide a universal high-throughput assay platform for future large-scale protein characterizations and therapeutics development.
Graphical Abstract
Big Mantle Wedge and Intraplate Volcanism in Alaska: Insight From Anisotropic Tomography
Authors: Liang Xuran , Zhao Dapeng , Hua Yuanyuan , Xu Yi‐Gang 
Published: December 2023

AbstractWe determine high‐resolution tomographic models of isotropic P‐wave velocity (Vp) and tilting‐axis anisotropy of the Alaska subduction zone using a large number of local and teleseismic data recorded at many portable and permanent network stations in and around Alaska. We find a flat high‐Vp slab in the mantle transition zone (410–670 km depths) beneath western Alaska, which is connected with the subducting Pacific slab at 0–410 km depths, suggesting that a big mantle wedge has formed under western Alaska. Our tilting‐axis anisotropy model reveals complex mantle flows in the asthenosphere. Corner flow in the mantle wedge above the subducting Pacific slab and toroidal flow in the big mantle wedge are revealed, which may cause the Cenozoic intraplate volcanoes in western Alaska and the Bering Sea. In central Alaska, the mantle wedge beneath the Denali volcanic gap is characterized by high‐Vp and subhorizontal fast velocity directions normal to the volcanic arc, which may reflect a remnant of the subducted Yakutat slab. In SE Alaska, the shallow subduction of the Wrangell slab is visible above 150 km depth, and hot mantle upwelling through the Wrangell‐Yakutat slab gap may contribute to the Wrangell volcanic field.