bluuebunny/crossref_metadata_2025_split huggingface dataset:
Principal causes of acute poisoning in an emergency service: experience between 2014 and 2021 at a University Hospital in Southwestern Colombia
Authors: Hurtado David , Quintero Jaime A. , Rodríguez Yeraldin Alejandra , Pérez Daniel Esteban , Paz Roger Figueroa , Diez-Sepúlveda Julio 
Published: February 2024

AbstractAcute poisonings are a global public health problem, which implies costs and disease burden for society. In Colombia, there is a significant underreporting of data on acute poisoning and data gaps on the toxicological profile of the population. This study aims to identify the epidemiology of acute poisoning in a high-complexity hospital in southwestern Colombia. A descriptive study with retrospective data collection was performed. The variables were expressed through the measure of central tendency and dispersion. Categorical variables were described in proportions. A total of 406 patients were included. The median age was 31 years (IQR 23–48), 56.2% were male, and only 19.2% had a history of mental illness. Suicidal intent represented 58.8% of the cases, and the most frequent route of exposure was the oral route (81.6%). The most prevalent groups of substances were pesticides (34.2%) and medicines (32%). The most common etiological agent was organophosphates (16.5%). Cholinergic toxidrome was the most common. The average stay in the ICU was 4.5 days (± 4.8), and the mortality was 4.2%. The principal causes of acute poisoning were drugs and pesticides, with a predominant etiology of organophosphates and depressants of the central nervous system. There was a significant predominance of young male patients with suicidal intent, low mental disorders, elevated unemployment rate, and similar mortality reported in other studies. This study improves the knowledge about acute poisoning in southwestern Colombian to carry out multicenter analytic studies.
A multilayer perceptron neural network approach for optimizing solar irradiance forecasting in Central Africa with meteorological insights
Authors: Mfetoum Inoussah Moungnutou , Ngoh Simon Koumi , Molu Reagan Jean Jacques , Nde Kenfack Brice Félix , Onguene Raphaël , Naoussi Serge Raoul Dzonde , Tamba Jean Gaston , Bajaj Mohit , Berhanu Milkias 
Published: February 2024

AbstractPromoting renewable energy sources, particularly in the solar industry, has the potential to address the energy shortfall in Central Africa. Nevertheless, a difficulty occurs due to the erratic characteristics of solar irradiance data, which is influenced by climatic fluctuations and challenging to regulate. The current investigation focuses on predicting solar irradiance on an inclined surface, taking into consideration the impact of climatic variables such as temperature, wind speed, humidity, and air pressure. The used methodology for this objective is Artificial Neural Network (ANN), and the inquiry is carried out in the metropolitan region of Douala. The data collection device used in this research is the meteorological station located at the IUT of Douala. This station was built as a component of the Douala sustainable city effort, in partnership with the CUD and the IRD. Data was collected at 30-min intervals for a duration of around 2 years, namely from January 17, 2019, to October 30, 2020. The aforementioned data has been saved in a database that underwent pre-processing in Excel and later employed MATLAB for the creation of the artificial neural network model. 80% of the available data was utilized for training the network, 15% was allotted for validation, and the remaining 5% was used for testing. Different combinations of input data were evaluated to ascertain their individual degrees of accuracy. The logistic Sigmoid function, with 50 hidden layer neurons, yielded a correlation coefficient of 98.883% between the observed and estimated sun irradiation. This function is suggested for evaluating the intensities of solar radiation at the place being researched and at other sites that have similar climatic conditions.
UV index-based model for predicting synthesis of (pre-)vitamin D3 in the mediterranean basin
Authors: Kallioğlu Mehmet Ali , Sharma Ashutosh , Kallioğlu Ayşan , Kumar Sunil , Khargotra Rohit , Singh Tej 
Published: February 2024

AbstractThe importance of solar radiation for the body’s ability to synthesize Vitamin D3 is well documented, yet the precise amount of sun exposure required to avoid Vitamin D insufficiency is less clear. To address this knowledge gap, this study sought to utilize the sun in a suitable period at the optimum dose by utilizing numerical simulations to determine the amount of Vitamin D3 synthesis in the skin according to season, time of day, and geographical location in Turkey. The study was carried out in three stages; in the first stage, daily, monthly, and annual values were determined in cases where the solar zenith angle has the active UV-B wavelength. The second stage determined the level of Vitamin D that can be synthesized in all skin types at 25% solar radiation exposure. In the third stage, the sun exposure time required for 1000 International Units (IU) for all skin types was calculated. According to the analysis, the yearly period of active synthesis of D3 on Earth lasts from the beginning of March to the third week of October. During the day, it is between 10:00 and 16:00. For 1000 IU/day, the average annual estimated times (minutes) are 5.05 for Type I, 6.3 for Type II, 7.6 for Type III, 11.35 for Type IV, 15.15 for Type V, and 25.25 for Type VI. The results of this paper will impact awareness for academic-medical users.
Disastrous cerebral and ocular vascular complications after cosmetic facial filler injections: a retrospective case series study
Authors: Zhao Fanfan , Chen Yao , He Dong , You Xiangxi , Xu Yuyun 
Published: February 2024

AbstractSoft tissue filler injections are among the most popular facial rejuvenation methods. Cerebral infarction and ophthalmic artery occlusion are rare and catastrophic complications, especially when facial cosmetic fillers are injected by inexperienced doctors. Radiologists and plastic surgeons need to increase their awareness of the complications associated with fillers, which allows early diagnosis and intervention to improve patient prognosis. Regarding the mechanism by which vascular occlusion occurs after facial filler injections, a retrograde embolic mechanism is currently the predominant theory. Numerous case reports have been presented regarding complications associated with injections of facial aesthetics. However, the small sample sizes of these studies did not allow for an adequate assessment of the clinical and imaging manifestations based on the location of the occlusion and the type of filler, and detailed elaboration of multiple cerebral infarctions is also lacking. Therefore, this study aimed to investigate the clinical and radiological features of severe cerebral and ocular complications caused by cosmetic facial filler injections. In addition, we discuss the pathogenesis, treatment, and prognosis of these patients. The clinical, computed tomography (CT), magnetic resonance imaging (MRI), and digital subtraction angiography (DSA) findings were described and analysed. Radiological examinations are crucial for demonstrating severe complications, and brain MRI is especially strongly suggested for patients with cosmetic filler-induced vision loss to identify asymptomatic cerebral infarctions. Extreme caution and care should be taken during facial injections by plastic surgeons.
Music literacy improves reading skills via bilateral orthographic development
Authors: Pantaleo Marta Maria , Arcuri Giulia , Manfredi Mirella , Proverbio Alice Mado 
Published: February 2024

AbstractConsiderable evidence suggests that musical education induces structural and functional neuroplasticity in the brain. This study aimed to explore the potential impact of such changes on word-reading proficiency. We investigated whether musical training promotes the development of uncharted orthographic regions in the right hemisphere leading to better reading abilities. A total of 60 healthy, right-handed culturally matched professional musicians and controls took part in this research. They were categorised as normo-typical readers based on their reading speed (syl/sec) and subdivided into two groups of relatively good and poor readers. High density EEG/ERPs were recorded while participants engaged in a note or letter detection task. Musicians were more fluent in word, non-word and text reading tests, and faster in detecting both notes and words. They also exhibited greater N170 and P300 responses, and target-non target differences for words than controls. Similarly, good readers showed larger N170 and P300 responses than poor readers. Increased reading skills were associated to a bilateral activation of the occipito/temporal cortex, during music and word reading. Source reconstruction also showed a reduced activation of the left fusiform gyrus, and of areas devoted to attentional/ocular shifting in poor vs. good readers, and in controls vs. musicians. Data suggest that music literacy acquired early in time can shape reading circuits by promoting the specialization of a right-sided reading area, whose activity was here associated with enhanced reading proficiency. In conclusion, music literacy induces measurable neuroplastic changes in the left and right OT cortex responsible for improved word reading ability.
Automated differentiation of mixed populations of free-flying female mosquitoes under semi-field conditions
Authors: Johnson Brian J. , Weber Michael , Al-Amin Hasan Mohammad , Geier Martin , Devine Gregor J. 
Published: February 2024

AbstractGreat advances in automated identification systems, or ‘smart traps’, that differentiate insect species have been made in recent years, yet demonstrations of field-ready devices under free-flight conditions remain rare. Here, we describe the results of mixed-species identification of female mosquitoes using an advanced optoacoustic smart trap design under free-flying conditions. Point-of-capture classification was assessed using mixed populations of congeneric (Aedes albopictus and Aedes aegypti) and non-congeneric (Ae. aegypti and Anopheles stephensi) container-inhabiting species of medical importance. Culex quinquefasciatus, also common in container habitats, was included as a third species in all assessments. At the aggregate level, mixed collections of non-congeneric species (Ae. aegypti, Cx. quinquefasciatus, and An. stephensi) could be classified at accuracies exceeding 90% (% error = 3.7–7.1%). Conversely, error rates increased when analysing individual replicates (mean % error = 48.6; 95% CI 8.1–68.6) representative of daily trap captures and at the aggregate level when Ae. albopictus was released in the presence of Ae. aegypti and Cx. quinquefasciatus (% error = 7.8–31.2%). These findings highlight the many challenges yet to be overcome but also the potential operational utility of optoacoustic surveillance in low diversity settings typical of urban environments.
Orthogonal mode couplers for plasmonic chip based on metal–insulator–metal waveguide for temperature sensing application
Authors: Butt Muhammad Ali , Piramidowicz Ryszard 
Published: February 2024

AbstractIn this work, a plasmonic sensor based on metal–insulator–metal (MIM) waveguide for temperature sensing application is numerically investigated via finite element method (FEM). The resonant cavity filled with PDMS polymer is side-coupled to the MIM bus waveguide. The sensitivity of the proposed device is ~ − 0.44 nm/°C which can be further enhanced to − 0.63 nm/°C by embedding a period array of metallic nanoblocks in the center of the cavity. We comprehend the existence of numerous highly attractive and sensitive plasmonic sensor designs, yet a notable gap exists in the exploration of light coupling mechanisms to these nanoscale waveguides. Consequently, we introduced an attractive approach: orthogonal mode couplers designed for plasmonic chips, which leverage MIM waveguide-based sensors. The optimized transmission of the hybrid system including silicon couplers and MIM waveguide is in the range of − 1.73 dB to − 2.93 dB for a broad wavelength range of 1450–1650 nm. The skillful integration of these couplers not only distinguishes our plasmonic sensor but also positions it as a highly promising solution for an extensive array of sensing applications.
Multiple geriatric syndromes in community-dwelling older adults in China
Authors: Wang Ling-Ying , Hu Zi-yi , Chen Hong-xiu , Tang Meng-lin , Hu Xiu-ying 
Published: February 2024

AbstractThis study aims to assess the prevalence of geriatric syndromes and identify factors associated with multiple geriatric syndromes in community-dwelling older adults in China. We utilized a convenience sampling method to recruit older adults and from one rural and one urban community in Chengdu, China, from October 2022 to March 2023. A total of 706 older adults aged 60 years or older were included. Ten geriatric syndromes were investigated including two mental disorders: depressive symptoms, cognitive impairment; and eight somatic disorders: pain, falls, sleep disturbance, constipation, polypharmacy, multimorbidity, malnutrition and frailty. Multiple geriatric syndromes were defined as an individual having two or more geriatric syndromes. The data obtained were analysed using descriptive statistics. The independent risk factors for multiple geriatric syndromes were assessed using a logistic regression model. This study found that 90.5% of the participants had at least one geriatric syndrome, with 72.8% experiencing multiple geriatric syndromes. The top four geriatric syndromes in our study were polypharmacy (58.5%), malnutrition/at risk of malnutrition (43.1%), multimorbidity (42.1%), and frailty/prefrailty (34.3%). Of the older adults, 368(52.1%) had only somatic disorders, 18(2.5%) had only mental disorders and 253 (35.8%) had somatic-mental disorders. According to the logistic regression analysis, residence, age, marriage, BMI, and self-related health were significantly associated with multiple geriatric syndromes among older adults. This study highlights that multiple geriatric syndromes are prevalent among community-dwelling older adults in China, and underscores the significance of certain demographic factors in their occurrence. Future longitudinal studies are needed to establish the temporal relationship between multiple geriatric syndromes and these demographic factors, as well as to explore causal relationships and effective prevention strategies for geriatric syndrome.
The effect of Immersive Virtual Reality on balance: an exploratory study on the feasibility of head-mounted displays for balance evaluation
Authors: Rosiak Oskar , Pietrzak Nikodem , Szczęsna Anna , Kulczak Izabela , Zwoliński Grzegorz , Kamińska Dorota , Konopka Wiesław , Jozefowicz-Korczynska Magdalena 
Published: February 2024

AbstractGlobal interest in applying virtual reality (VR) in research and medicine has grown significantly, with potential benefits for patients suffering from balance disorders, instability, and a high risk of falling. This exploratory study assesses the impact of immersive VR (IVR) delivered through a head-mounted display (HMD) on balance and explores the feasibility of using the HMD VR unit as a standalone posturography tool. Using the Meta Quest 2 HMD and a mid-range Android smartphone equipped with standard sensors, the research employed a VR environment that simulated a ship at sea, with thirty-eight healthy participants with no otoneurologic abnormalities. Measurements were conducted in repeated trials, including static assessments on both stable ground and foam, as well as a 3-m walk. This was conducted in two settings: one within a VR environment with three different intensity levels and the other in non-VR settings. Statistical analysis and clinical evaluation revealed that IVR with HMD influences head-level sway velocity, which correlates with increased visual disturbance, suggesting its potential as a low-risk standalone posturography tool.
First molecular detection and genetic diversity of Hepatozoon sp. (Apicomplexa) and Brugia sp. (Nematoda) in a crocodile monitor in Nakhon Pathom, Thailand
Authors: Junsiri Witchuta , Kamkong Patchana , Taweethavonsawat Piyanan 
Published: February 2024

AbstractThe crocodile monitor (Varanus salvator) is the most common monitor lizard in Thailand. Based on habitat and food, they have the potential to transmit zoonoses, with a high possibility of infecting ectoparasites and endoparasites. Diseases that could infect crocodile monitors and be transmitted to other animals, including humans. This research aims to identify and evaluate the phylogenetic relationships of Hepatozoon sp. and sheathed microfilaria in crocodile monitors. The phylogenetic analyses of Hepatozoon, based on 18S rRNA, and sheathed microfilaria, based on the COX1 gene, revealed that the Hepatozoon sp. were grouped with H. caimani, while sheathed microfilaria were grouped together with B. timori. This study provides insights into the genetic diversity and host-parasite interactions of hemoparasites in crocodile monitors in Thailand.
The impact of the Madden-Julian oscillation on spring and autumn afternoon diurnal convection in Sri Lanka
Authors: Huang Wan‑Ru , Koralegedara Suranjith Bandara , Chiang Tzu-Yang , Lee Cheng‑An , Tung Po-Han , Chien Yu-Tang , Deng Liping 
Published: February 2024

AbstractThis study examines the impact of strong Madden-Julian Oscillation (MJO) phases (P1–P8) on diurnal rainfall patterns focusing on Afternoon Diurnal Convection (ADC) events in Sri Lanka during 2001–2020 spring and autumn. Daily mean rainfall increases (decreases) during the P2-to-P3 (P6-to-P7) MJO phases in both seasons, while the diurnal rainfall amplitude peaks during the P2-to-P3 (P8-to-P1) MJO phases in spring (autumn). ADC events also occur more frequently and intensely during MJO P2-to-P3 (P8-to-P1) in spring (autumn). The MJO’s modulation of diurnal rainfall amplitude and ADC events is more apparent in autumn than in spring. Active MJO phases enhance the westward propagation of diurnal rainfall associated with ADC events, sustained by moisture flux convergence and enhanced upward motion. The prevailing mid-to-upper level easterly wind, combined with deep convection over Sri Lanka, contributes to a more pronounced westward propagation during the P2-to-P3 (P8-to-P1) phases for ADC events in spring (autumn).
Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations
Authors: Dopeso Higinio , Gazzo Andrea M. , Derakhshan Fatemeh , Brown David N. , Selenica Pier , Jalali Sahar , Da Cruz Paula Arnaud , Marra Antonio , da Silva Edaise M. , Basili Thais , Gusain Laxmi , Colon-Cartagena Lorraine , Bhaloo Shirin Issa , Green Hunter , Vanderbilt Chad , Oesterreich Steffi , Grabenstetter Anne , Kuba M. Gabriela , Ross Dara , Giri Dilip , Wen Hannah Y. , Zhang Hong , Brogi Edi , Weigelt Britta , Pareja Fresia , Reis-Filho Jorge S. 
Published: February 2024

AbstractCDH1 (E-cadherin) bi-allelic inactivation is the hallmark alteration of breast invasive lobular carcinoma (ILC), resulting in its discohesive phenotype. A subset of ILCs, however, lack CDH1 genetic/epigenetic inactivation, and their genetic underpinning is unknown. Through clinical targeted sequencing data reanalysis of 364 primary ILCs, we identified 25 ILCs lacking CDH1 bi-allelic genetic alterations. CDH1 promoter methylation was frequent (63%) in these cases. Targeted sequencing reanalysis revealed 3 ILCs harboring AXIN2 deleterious fusions (n = 2) or loss-of-function mutation (n = 1). Whole-genome sequencing of 3 cases lacking bi-allelic CDH1 genetic/epigenetic inactivation confirmed the AXIN2 mutation and no other cell-cell adhesion genetic alterations but revealed a new CTNND1 (p120) deleterious fusion. AXIN2 knock-out in MCF7 cells resulted in lobular-like features, including increased cellular migration and resistance to anoikis. Taken together, ILCs lacking CDH1 genetic/epigenetic alterations are driven by inactivating alterations in other cell adhesion genes (CTNND1 or AXIN2), endorsing a convergent phenotype in ILC.
Widespread contamination of soils and vegetation with current use pesticide residues along altitudinal gradients in a European Alpine valley
Authors: Brühl Carsten A. , Engelhard Nina , Bakanov Nikita , Wolfram Jakob , Hertoge Koen , Zaller Johann G. 
Published: February 2024

AbstractPesticides are transferred outside of cropland and can affect animals and plants. Here we investigated the distribution of 97 current use pesticides in soil and vegetation as central exposure matrices of insects. Sampling was conducted on 53 sites along eleven altitudinal transects in the Vinschgau valley (South Tyrol, Italy), in Europe’s largest apple growing area. A total of 27 pesticides (10 insecticides, 11 fungicides and 6 herbicides) were detected, originating mostly from apple orchards. Residue numbers and concentrations decreased with altitude and distance to orchards, but were even detected at the highest sites. Predictive, detection-based mapping indicates that pesticide mixtures can occur anywhere from the valley floor to mountain peaks. This study demonstrates widespread pesticide contamination of Alpine environments, creating contaminated landscapes. As residue mixtures have been detected in remote alpine ecosystems and conservation areas, we call for a reduction of pesticide use to prevent further contamination and loss of biodiversity.
Trait-mediated processes and per capita contributions to ecosystem functioning depend on conspecific density and climate conditions
Authors: Sanders Trystan , Solan Martin , Godbold Jasmin A. 
Published: February 2024

AbstractThe ecological consequences of environmental change are highly dependent on the functional contributions of the surviving community, but categorical descriptors commonly used to project ecosystem futures fail to capture context dependent response variability. Here, we show that intraspecific variability for a range of sediment-dwelling marine invertebrates is moderated by changes in the density of conspecifics and/or climatic conditions. Although these trait-mediated changes result in modifications to ecosystem properties, we find that the contributions of individuals to functioning are not necessarily additive but, instead, are a result of alterations to per capita performance. Our findings also indicate that trait variation within species can exert a greater influence on functioning than that of trait variation between species. Hence, projections of likely functional outcomes that scale from mean trait values are unlikely to be robust, highlighting a need to account for how and when intraspecific variability results in context-dependent community responses to change.
Future transition from forests to shrublands and grasslands in the western United States is expected to reduce carbon storage
Authors: Kodero Jared M. , Felzer Benjamin S. , Shi Yuning 
Published: February 2024

AbstractClimate change is expected to impact vegetation in the western United States, leading to shifts in dominant Plant Functional Types and carbon storage. Here, we used a biogeographic model integrated with a biogeochemical model to predict changes in dominant Plant Functional Type by 2070−2100. Results show that under the Representative Concentration Pathway 4.5 scenario, 40% of the originally forested areas will transition to shrubland (7%) or grassland (32%), while under the Representative Concentration Pathway 8.5 scenario, 58% of forested areas shift to shrubland (18%) or grassland (40%). These shifts in Plant Functional Types result in a net overall loss in carbon storage equal to −60 gigagram of carbon and −82 gigagram of carbon under Representative Concentration Pathway 4.5 and 8.5, respectively. Our findings highlight the need for urgent action to mitigate the effects of climate change on vegetation and carbon storage in the region.