bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Invention of a Predictor Plot for Evaluating the Response of the Compressive Strength of Geopolymer Cement to Changes in Temperature and Pressure
Authors: Zulkarnain Nurul Nazmin , Ab Hamid Afif Izwan , Sazali Yon Azwa , A Razak Ahmad Amirhilmi , Habarudin Mohd Firdaus 
Published: October 2023

Abstract
The design of cement must consider the potential influence of fluctuations in formation pressure and temperature within the wellbore. The possibility of geopolymer cement as an alternative to Ordinary Portland Cement (OPC) is being considered in support of the Paris Agreement. However, previous research on geopolymer has focus on construction industry which the studies were conducted at atmospheric condition, hence limited study available that experimenting both pressure and temperature variation on the cement. Therefore, the current study aims to observe the flexibility of geopolymer cement for well application by conducting compressive strength test for cement that have been simulated at pressure range between 14.7 and 5000 psi and temperature between 60 and 120 °C.
The study involves two geopolymer cement formulations and cured for 24 hours at 15 different condition, which the mixing and curing according to American Petroleum Institute Recommended Practice (API RP) 10B-2. The API compressive strength tester is used to perform the destructive compressive strength. The results are recorded and analysed using a 3D surface plot to observe the trend of compressive strength when exposed to various wellbore condition.
The research finding indicates that the compressive strength of the cement is notably influenced by temperatures, while it has been observed that the pressure does not exert any discernible influence on the enhancement of compressive strength in geopolymer cement. The impact of simulated pressure on cement compaction, which leads to densification, may not have a major effect on its strength compared to the influence of temperature, which primarily affects the chemical reactions within the cement structure.
The anticipated outcomes of the study are anticipated to offer novel perspectives that may enhance the efficacy of geopolymer cement within the context of oil and gas. It is recommended to create 3D plots of geopolymer cement at temperatures and pressures below 60°C and 2000 psi to observe the performance of cement in depleted wells, which are one of the focus CCUS well. The strength can be estimated prior to conduct other functional test such as, thickening time and fluid loss. However, the inclusion of other additives into the formulation might alter the trend, which several points need to validate prior to use the plot for the estimation. Further study recommended that the data from the current research to be combined with similar information from the previous analysis to strengthen the plot.
Fracture Gas Reservoir Drilling Campaign - Challenges and Lessons Learnt from Suban Field in Indonesia: Case Study Suban-X
Authors: Rismanda Jeff , Permana Budi R , Widyaningsih Ratih 
Published: October 2023

Abstract
Suban Field was discovered in 1972 and has been abandoned until 1998. The fracture reservoir has a characteristic high permeability compared to the matrix reservoir. This special characteristic is causing losses in drilling at the reservoir section. In the early drilling campaign (1972 – 2006), conventional drilling (loss and cured) was applied to overcome the challenge. However, this method has prolonged drilling time and caused high skin in terms of reservoir productivity. Since 2010 until now, Managed Pressure Drilling (MPD) had been applied to optimize drilling time and resulted in less skin to have good reservoir productivity. During this period, there are some challenges in MPD application especially due to depleted reservoir pressure (~6 ppg EMW) forcing the engineering team to optimize the creative design that aligned with project optimization without jeopardizing the operation.
In the early stage of MPD drilling campaign, a downhole valve was installed as a mechanical wellbore isolation tool while tripping in/out when losses occur. The performance of downhole valve has been evaluated from the last 5 wells drilling campaign before drilling Suban-X well with a statistical evaluation showing 6 successful isolations out of 18 total attempts.
Some experiments were performed when the downhole valve was not closing properly on the last 3 wells during the Drilling and Completion campaign. The experiments were successful to suppress the gas by bull heading the well with a sufficient rate of water, periodical high viscosity sweep injection as a precaution for gas migration and having Dual Seal Element Adapter installed on Rotary Control Device (RCD).
Based on the above circumstances, prior to drill Suban-X in 2021, the decision was made to drill Suban-X well with MPD without downhole valve installed. The mitigation to overcome gas migration and suppress the gas was by preparing sufficient water from water pond at wellsite and establishing a water network to keep filling the water pond. As a result, the well was successfully drilled to TD safely without any issues. The innovation to eliminate the utilization of downhole valve provides cost-reduction for material and drilling time savings. This innovation was first implemented in Corridor Block and is currently being used as a basic template for future drilling campaigns.
Extending the Production Lifetime of Oil Well with Paraffin Problems Through Thermal Application of Mobile Steam Injection of Mature Field
Authors: Pratama Satria , Azhim Luthfan Nur , Suwitno Agus , Daniel Sofyan , Saputra Medyansah Eka , Susilo M. Danang , Imansyah Ali Ganjar , Sucipto _ , Kuncoro Anang Arie 
Published: October 2023

Abstract
Oil wells that produce crudes with high paraffin content usually lead to precipitation due to deposits forming near wellbore up to downhole equipment of artificial lift which potentially cause downhole problems resulting loss production opportunities. This paper presents success practical case from PT Pertamina Hulu Rokan Zona 4 in handling paraffin deposition in oil well producers with most widely used sucker rod pump as artificial lift without well services job.
Thermal treatment has been used in a number of paraffin deposition problems, steam injection is the one of method to overcome the deposits in well producers. Mobile Steam Injection (Steamject) is built by steam generator installed on the truck which has capability to produce steam from water which has adequate heat capacity to melt the paraffin deposits and the steam will be injected into annulus with temperature up to 250 oC. Flexibility of Mobile Steamject provides prompt action to remove the deposits from the well during the production phase.
Early detection of downhole problem such as plunger stuck was able to identified from dynacard card analysis. Once the problem is confirmed, Steamject will propagate the heat through annulus into well and downhole equipment to reduce restriction of pump volume displacement. After the steam was completely injected, production will start to continue while observing the production test result and re-run the dynacard analysis. Two promising advantages of Steamject are the deliverability and cost efficiency as implemented in Benakat Barat Operation Area. Based on practical case, Steamject can reduce the operation time up to 116 hours. Then, the faster the deliverability time, the lower operation cost.
Practical case presented in this paper about steam injection to overcome paraffin deposition provides lesson learned for operation excellences. Implementation of Mobile Steamject has opportunity in any mature field that needs flexible and low-cost solution of paraffin problems.
Fluid and Proppant Distribution and Fracture Geometry Calibration Using Permanent Fiber-Optic Sensing DAS/DTS – Oman Case Study
Authors: Shoaibi Sultan , Farsi Shaima , Suchta Bogdan , Persac Stephen , Wakwak Amr , Gorgi Sam 
Published: October 2023

Abstract

Objective/Scope
In the Sultanate of Oman, hydraulic fracturing technology is used to increase oil and gas production from low permeability reservoirs. To improve the efficiency of operations, operating companies aim to optimize the quality of information used for decision-making and therefore reduce cost. One tool to achieve the efficiency is to reduce the number of activities by combining multiple productive layers in a vertical well to be stimulated in a single fracturing treatment. This strategy, in turn, requires information as to what extent those intervals have been stimulated. Fiber-optic sensing technologies were deployed in a well to monitor the fluid/proppant transport through all the perforation clusters across the target reservoirs. The two technologies used were Distributed Temperature Sensing (DTS) and Distributed Acoustic Sensing (DAS). This paper presents the deployment of fiber-optic sensing technologies in the Sultanate of Oman to determine fluid/proppant distribution during fracturing treatment when multiple formations are perforated and fractured. This paper provides the data obtained from fiber-optic sensing with the objective of quantifying clusters fluid and proppant distribution.

Methods/Procedures/Process
The fiber-optic systems deployments were installed outside the cemented casing in targeted well to understand current and to optimize future fracturing treatments in Oman. The acquired DAS/DTS data was processed in real time during fracture propagation and cleanup periods. A stimulation treatment was designed using a 3D hydraulic fracturing simulator, and the resulting fracture geometry was compared to that estimated from optical fiber. The DAS/DTS data was also analyzed in real time during treatment to determine cluster intake efficiency.

Results/Observations/Conclusions
Results of the DAS/DTS monitoring technology during hydraulic fracturing treatment have proven it as a viable technology for fracturing diagnostics. An excellent fluid/proppant distribution match was achieved between the simulator and DAS/DTS results, clearly demonstrating inequality in proppant distribution. Top perforations took approximately 75% of the injected fluid and proppant, leaving other perforated reservoirs unstimulated. This valuable information led to a vital decision that additional fracturing stages must be performed to effectively stimulate all reservoirs.

Novelty/Additive Information
The novel approach of incorporating results from DAS/DTS provided validation of the designed fracturing treatment. The DAS-acquired data indicated non-uniform proppant distribution across targeted reservoirs. A 3D simulator was used to calibrate the geological model based on DAS/DTS response.
Transient Pressure Interference during CO2 Injection in Saline Aquifers
Authors: Zeidouni Mehdi 
Published: October 2023

SummaryCO2 injection in subsurface geological formations (e.g., deep saline aquifers) causes pressure perturbations over a large area surrounding the injection well. Observation wells are widely considered in geologic CO2 storage (GCS) projects where the pressure perturbation induced by CO2 injection is measured. In this work, we use analytical and numerical modeling tools along with field data to examine the pressure behavior in GCS projects before and after CO2 arrival at an observation well. Before CO2 arrival, a baseline pressure trend is established which corresponds to single-phase brine flow across the observation well (approximated by the Theis solution). Therefore, analysis of early time pressure data is straightforward, provides the single-phase flow characteristics (mobility and storativity), and helps in establishing a baseline pressure change that can be extended beyond the single-phase flow period at the observation well.Upon CO2 arrival, a departure from this baseline trend is expected. For the pressure to detect the CO2 arrival at an observation well, the departure from baseline pressure behavior must be significant and well above the background noise levels. We use existing analytical models to determine the strength of the expected pressure departure signal from the baseline trend upon CO2 arrival. The strength of the expected pressure departure is found to be directly proportional to the change in the mobility upon CO2 arrival. Larger change in the flow mobility—compared with single-phase brine mobility—results in a stronger pressure departure signal. In addition, the departure is found to be upward (downward) from the baseline pressure trend when the mobility ratio is less (more) than unity. We present a pressure analysis approach through application to synthetic and field data and show the characteristic pressure behavior before and after CO2 arrival. We show that while generally the pressure can be either above or below the expected baseline pressure trend, it would be likely above the baseline upon CO2 arrival. This is because the mobility ratio becomes less than unity after CO2 arrival. We show that depending on the reservoir characteristics, changes in the pressure trend may or may not be sufficient to detect the CO2 arrival.
Multimodal Haptic Interaction with a Carbon Nanotube-based Tactile Oral Pad
Authors: Liu Xiaogang , Hou Bo , Yang Dingzhu , Ren Xiaoyuan , Yi Luying 
Published: October 2023

Abstract

Assistive wearable systems incorporating soft tactile sensors to transmit spatiotemporal touch patterns have become increasingly prevalent, particularly in biomedical robotics. Although these systems have shown promise in tasks such as typing and device operation, their ability to convert pressure patterns into specific control commands has been limited, resulting in less dexterity and intuitiveness than finger-operated electronic devices. Here, we report the fabrication of a tactile oral pad (oPad) equipped with a touch sensor array made of a carbon nanotube silicone composite. The tactile oPad can detect a broad range of strain, while also functioning as an electronic platform that can be manipulated by the tongue and teeth, resembling finger movement on a touchscreen. Combined with a recurrent neural network, we demonstrate the cooperative control of tongue sliding (below 50 kPa pressure) and teeth clicking (above 500 kPa pressure) for efficient typing, gaming, and wheelchair control. The lightweight, flexible, and cost-effective nature of this tactile oPad has potential to advance assistive devices, smart robots, and health monitoring technologies.
Unveiling the Molecular Networks Underlying Cellular Impairment in Saccharomyces cerevisiae: Investigating the Effects of Magnesium oxide Nanoparticles on Cell Wall Integrity and Endoplasmic Reticulum Stress Response
Authors: Chauhan Shraddha , Tomar Raghuvir Singh 
Published: October 2023

Abstract
Magnesium oxide nanoparticles (MgO-NPs) are highly versatile and have been extensively utilized in diverse industrial and biomedical applications due to their exceptional physical and chemical properties. However, the potential harms to human health and the environment from their use continue to be of great trepidation. In this study, we delved deep into the intricate molecular mechanisms underlying the detrimental effects of MgO-NPs on the growth and viability of the model yeast Saccharomyces cerevisiae. Our findings demonstrate that as the concentration of MgO-NPs increases, it leads to a dose-dependent reduction in the growth and viability of the yeast cells. We further investigated the underlying mechanisms of MgO-NP toxicity and found that it causes damage to the cell membrane, which in turn triggers an endoplasmic reticulum (ER) stress response. The response to ER stress involves an increase in the expression of genes that play a role in protein folding, maintaining protein quality, and removing misfolded proteins via ER-associated degradation (ERAD). In response to treatment with MgO-NPs, we observed the activation of the cell wall integrity (CWI) pathway, it caused the activation of chitin production genes and an increase in the amount of chitin in the cells. These findings highlight the multifaceted detrimental nature of MgO-NPs, which involve the interplay of various molecular networks and signaling pathways.
Molecular and Phenotypic Characteristics of Bardet-Biedl Syndrome in Chinese Patients
Authors: shiyang Gao , Zhang Qianwen , Ding Yu , Wang Libo , Li Zhiying , Hu Feihan , Yao Ru-en , Yu Tingting , Chang Guoying , Wang Xiumin 
Published: October 2023

Abstract
Background
Bardet-Biedl syndrome (BBS) is a type of non-motile ciliopathy. To date, 26 genes have been reported to be associated with BBS. However, BBS is genetically heterogeneous, with significant clinical overlap with other ciliopathies, which complicates diagnosis. Disability and mortality rates are high in BBS patients; therefore, it is urgent to improve our understanding of BBS. Thus, our study aimed to describe the genotypic and phenotypic spectra of BBS in China and to elucidate genotype-phenotype correlations.
Methods
Twenty Chinese patients diagnosed with BBS were enrolled in this study. We compared the phenotypes of Chinese BBS patients in this study with those from other countries to analyze the phenotypic differences across patients worldwide. In addition, genotype-phenotype correlations were described for our cohort. We also summarized all previously reported cases of BBS in Chinese patients (71 patients) and identified common and specific genetic variants in the Chinese population.
Results
Twenty-eight variants, of which 10 are novel, in 5 different BBS-associated genes were identified in 20 Chinese BBS patients.. By comparing the phenotypes of BBSome-coding genes (BBS2,7,9) with those of chaperonin-coding genes (BBS10,12), we found that patients with mutations in BBS10 and 12 had an earlier age of onset (1.10 Vs. 2.20, p < 0.01) and diagnosis (4.64 Vs. 13.17, p < 0.01), whereas patients with mutations in BBS2, 7, and 9 had a higher body mass index (28.35 Vs. 24.21, p < 0.05) and more vision problems (p < 0.05). Furthermore, in 91 Chinese BBS patients, mutations were predominant in BBS2 (28.89%) and BBS7 (15.56%), and the most frequent variants were in BBS2: c.534 + 1G > T (10/182 alleles) and BBS7: c.1002delT (7/182 alleles), marking a difference from the genotypic spectra of BBS reported abroad.
Conclusions
We recruited 20 Chinese patients with BBS for genetic and phenotypic analyses, and identified common clinical manifestations, pathogenic genes, and variants. We also described the phenotypic differences across patients worldwide and among different BBS-associated genes. This study involved the largest cohort of Chinese patients with BBS, and provides new insights into the distinctive clinical features of specific pathogenic variants.
RETRACTED: Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild- type metastatic colorectal cancer: The PERSEIDA (Cohort 2) Study
Authors: Valladares-Ayerbes Manuel , Safont Maria José , Flores Encarnación González , García-Alfonso Pilar , Aranda Enrique , Muñoz Ana-Maria López , Ferrer Esther Falcó , Nogueras Luís Cirera , Rodríguez-Salas Nuria , Aparicio Jorge , Muñoz Marta Llanos , Cáceres Paola Patricia Pimentel , Trujillo Oscar Alfredo Castillo , Tocino Rosario Vidal , Fernández Mercedes Salgado , Salud-Salvia Antonieta , Sureda Bartomeu Massuti , Garcia-Carbonero Rocio , Conesa Maria Ángeles Vicente , Vila Ariadna Lloansí 
Published: October 2023

Abstract

The authors have requested that this preprint be removed from Research Square.
Cephalometric and digital model analysis of Dentoskeletal effects of Infrazygomatic miniscrew vs. Essix- anchored Carriere Motion appliance for distalization of maxillary buccal segment: A randomized clinical trial
Authors: Ghozy Eglal Ahmed , Albelasy Nehal Fouad , Shamaa Marwa Sameh , El-Bialy Ahmed A. 
Published: October 2023

Abstract
Trial design: parallel.
Objective: To compare skeletally anchored Carriere Motion appliance (CMA) for distalization of the maxillary buccal segment vs. Essix anchored CMA.
Methods: Thirty-two class II malocclusion patients were randomly allocated into two equal groups. One group was treated with infrazygomatic (IZC) miniscrew- anchored CMA (IZCG) and the other group treated with Essix retainer- anchored CMA (EXG). Two lateral cephalograms and two digital models for upper and lower arches were taken for each patient: immediately before intervention and after distalization had been completed.
Results: Distalization period was not significantly different between the two groups. In contrast to EXG, IZCG showed insignificant difference in ANB, lower incisor proclination, and mesial movement of the lower first molar. There was significant rotation with distal movement of maxillary canine and first molar in both groups.
Conclusion: IZC anchored CMA could eliminate the side effects of class II elastics regarding lower incisor proclination, mesial movement lower molars with a more significant amount of distalization of the maxillary buccal segment but with significant molar rotation.
Trial registration: The ClinicalTrials.gov Protocol Registration and Results System (PRS) has this RCT registered as (NCT05499221) on 12/08/2022.
Three-dimensional radiographic analysis of mandibular homonym premolars using cone beam computed tomography
Authors: Jin Hong , Wang Huiwen , Zhu Tingting , Wang Jingyan , Yang Lianfeng , Gu Peiyu , Leng Diya , Wu Daming 
Published: October 2023

Abstract
Purpose: To evaluate the three-dimensional radiographic characterizations of mandibular homonym premolars (MHPs) using cone beam computed tomography (CBCT).
Methods:CBCT images of 124 patients with MHPs were collected. The 3-dimensional radiographic characterizations of the MHPs were evaluated using NNT software, including the number, position, direction of torsion, bilateral symmetry, relationship to adjacent teeth and associated complications. The gender and age differences of these radiographic characterizations were analyzed.
Results:A total of 241 MHPs were found in the mandibular premolar regions. Most of the patients with MHPs were adolescent males (10~20 years). The majority type of MHPs was single (41.94%), and most of the MHPs were located lingually within the mandibular premolar regions. 66.94% of the MHPs were asymmetrically distributed.
Males were primarily asymmetrically distributed, whereas females were more symmetrically distributed, with statistically significant differences (P<0.05). The MHPs were mainly located on the lingual side of the mandibular basal bone (90.87%), and the torsion angle was predominant >45° (57.26%), the axial angle was dominant (29.84%), and the axial position was usually orthogonal (73.86%). Most of the patients had adjacent teeth affected by the MHPs (57.26%).
Conclusion: There were gender and age differences in the occurrence characteristics of MHPs. MHPs had certain 3-dimensional spatial positional distribution characteristics. CBCT can accurately analyze the radiographic characterizations of MHPs.