bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemp Seed Oil Derived Rigid Polyurethane Foams and Their Underlying Flame Retardancy Properties
Authors: Jariwala Sagar , Desai Yash N , Sahu Pranabesh , Gupta Ram K. 
Published: November 2023

Abstract
Green manufacturing and reducing our cultural dependency on petrochemicals have been the global interest currently, especially in the polyurethane industry segments. We report the fabrication of rigid polyurethane foams (RPUFs) and their flame-retardant property from hemp seed oil as an alternative to petrochemical-based polyols. The cold-pressed hemp-seed oil (HSO) was first oxidized to epoxidized triglyceride oils with acetic acid and hydrogen peroxide, followed by a ring-opening reaction with methanol to fabricate hemp bio-polyols. The formation of polyols was characterized using FT-IR, hydroxyl, and acid values. The bio-polyol was used in different proportions with commercial polyols and other foaming ingredients to produce rigid polyurethane foams via a one-step process. Dimethyl methylphosphonate (DMMP), triethyl phosphate (TEP), and expandable graphite (EG) were added during the foam preparation to improve flame retardancy. The produced foams were analyzed for their apparent density, mechanical properties, thermal degradation behavior, closed cell content, flammability, and cellular morphology. The effect of different flame retardants had a significant influence on the cellular structures, closed-cell content, density, and compressive strength of the polyurethane. A significant improvement in anti-flaming properties was observed as the neat HSO-based foam showed a burning time of 110 sec and a weight loss of 82%, whereas 10 wt.% of TEP displayed a reduced burning time and weight loss of 19 sec and 5%, respectively. DMMP and EG-based RPUFs exhibited similar flame retardancy and mechanical properties relative to neat HSO-based foam. The results demonstrated in this work proposed a potential combination of bio-polyols and commercial polyols as a strategy to fabricate flame-retardant polyurethane foam for high-performance applications.
Metabolic and genetic risk factors associated with pre-diabetes and type 2 diabetes in Thai healthcare employees: a long-term study from the Siriraj Health (SIH) Cohort Study
Authors: Mongkolsucharitkul Pichanun , Suta Sophida , Manosan Thamonwan , Surawit Apinya , Pumeiam Sureeporn , Pinsawas Bonggochpass , Pongkunakorn Tanyaporn , Ophakas Suphawan , Ratanasuwan Winai , Homsanit Mayuree , Charoencholvanich Keerati , Udomphorn Yuthana , Suktitipat Bhoom , Mayurasakorn Korapat 
Published: November 2023

Abstract
Background
The study of non-communicable diseases (NCDs) in a developing country like Thailand has rarely conducted in long-term cohort, especially in working-age population. We aim to assess the prevalence and incidence of risk factors and their associations underlying NCDs, especially type-2 diabetes mellitus (T2DM) among healthcare workers enrolled in the Siriraj Health (SIH) study cohort.
Methods
SIH study was designed as a longitudinal cohort and conducted at Siriraj hospital, Thailand. A total 5,011 participants (77% Female) were recruited and follow-up. Physical examinations, blood biochemical, family history, behavior and genetics factors were assessed.
Results
The average age was 35.44 ± 8.24 years and 51% of participants were overweight and obese. We observed men were more likely to have prevalence to T2DM and dyslipidemia (DLP) more than woman. Obese were significantly increased with prediabetes and T2DM (P < 0.001). Additionally, aging, obesity, metabolic syndrome, and DLP were associated with the development of prediabetes and T2DM. The minor T allele of the rs7903146(C/T) and rs4506565 (A/T) was associated with high risk of development of T2DM with an odds ratio of 2.74 (95% confidence interval [CI]: 0.32–23.3) and 2.71 (95% CI: 0.32–23.07), respectively; however, they were statistically insignificant (P > 0.05).
Conclusion
The SIH study's findings provide a comprehensive understanding of the health status, risk factors, and genetic factors related to T2DM in a specific working population and highlight areas for further research and intervention to address the growing burden of T2DM and NCDs.
Exploring the Relationship Between Lymphatic System Damage and Insulin Resistance in T2DM Based on Vascular Periadventitial Tensor Analysis and Triglyceride-Glucose Index
Authors: Xu Shan , Wang Xu-Yang , Yang Dong , Zhang Die , Du Li-Na , Chen Qing-Qing , Yang Yun , Lin Lin , Shen Jing , Wu Jianlin 
Published: November 2023

Abstract
Type 2 diabetes mellitus (T2DM) can lead to dysfunction in the brain's glymphatic system, but the relationship between glymphatic system function and insulin resistance remains unclear. The aim of this study was to investigate the connection between changes in the brain's glymphatic system function in T2DM and the surrogate marker for insulin resistance, the Triglyceride-Glucose Index (TyG). A total of 28 T2DM patients (T2DM group) and 24 healthy volunteers (HC group) were included in this study. We outlined circular regions with a diameter of 5.0 mm on diffusion tensor imaging (DTI) in the projection and association fibers in the body of the lateral ventricle. We compared the differences in DTI-ALPS index and related fiber diffusivity between the two groups. Additionally, TyG index in T2DM patients was calculated based on fasting blood glucose and triglyceride levels. Age was included as a covariate to analyze the correlation between the ALPS index and TyG index in T2DM patients. The results showed that the ALPS index and Dxproj in the T2DM group were lower than those in the HC group, while Dyproj was higher than in the HC group. In the T2DM group, the ALPS index, Dxassoc, and TyG index were all negatively correlated. The decreased ALPS index and fiber diffusivity in T2DM patients may be associated with the TyG index, suggesting a relationship between insulin resistance, lymphatic system damage, and white matter microstructure.
Increasing nurses’ occupational well-being: the role of career shocks, job crafting and supervisor autonomy support
Authors: Zhang Ying , Bu Xing , Zhang Na 
Published: November 2023

Abstract

Background
This study aims to explore the influence of career shocks on nurses’ occupational well-being through job crafting and the moderating role of supervisor autonomy support.
Method
The present study used a cross-sectional design. And the study included 714 frontline nurses in China, and we used structural equation modelling (SEM) to test our hypotheses.
Results
Job crafting mediated both the relationship between positive career shocks and occupational well-being and the relationship between negative career shocks and occupational well-being. Supervisor autonomy support moderated the indirect relationships.
Conclusions
Positive and negative career shocks could increase and impair nurses’ occupational well-being through job crafting, respectively. We contribute to helping nurses make sense of career shocks and preparing for career shocks, and hospital administrators and nurses’ direct supervisors can help nurse better cope with career shocks in attending job crafting activities and providing more autonomy supports.
Integration of National Health Insurance Claim Data and Animal Models Reveals Fexofenadine as a Promising Repurposed Drug for Parkinson’s Disease
Authors: Kim Jae-Bong , Kim Yujeong , Kim Soo-Jeong , Ha Tae‑Young , Kim Dong-Kyu , Kim Dong Won , So Minyoung , Kim Seung Ho , Woo Hyun Goo , Yoon Dukyong , Park Sang Myun 
Published: November 2023

Abstract
Background
Parkinson’s disease (PD) is a common and costly progressive neurodegenerative disease of unclear etiology. A disease-modifying approach that can directly stop or slow its progression remains a major unmet need in the treatment of PD. A clinical pharmacology-based drug repositioning strategy is a useful approach for identifying new drugs for PD.
Methods
We analyzed claims data obtained from the National Health Insurance Service (NHIS), which covers a significant portion of the South Korean population, to investigate the association between antihistamines, a class of drugs commonly used to treat allergic symptoms by blocking H1 receptors, and PD in a real-world setting. Additionally, we validated this model using various animal models of PD such as the 6-hydroxydopmaine (6-OHDA), α-synuclein preformed fibrils (PFF) injection, and Caenorhabditis elegans models. Finally, whole transcriptome data and Ingenuity Pathway Analysis (IPA) were used to elucidate drug mechanism pathways.
Results
We identified fexofenadine as the most promising candidate using National Health Insurance claims data in the real world. In several animal models, including the 6-OHDA, PFF injection, and C. elegans models, fexofenadine ameliorated PD-related pathologies. RNA-seq analysis suggested that fexofenadine is effective in PD via inhibition of peripheral immune cell infiltration into the brain.
Conclusion
This approach, which combines National Health Insurance claims data and animal model systems, provides insights into the development of novel therapeutics for PD.
Comparison of three-dimensional imaging of the nose using three different 3D- photography systems: an observational study
Authors: Ritschl Lucas M. , Classen Carolina , Kilbertus Paul , Eufinger Julia , Storck Katharina , Fichter Andreas M. , Wolff Klaus-Dietrich , Grill Florian D. 
Published: November 2023

Abstract
Background New 3D technologies for superficial soft tissue changes, especially in plastic and reconstructive surgical procedures, can improve the planning and documentation of facial surgeries. The purpose of this study was to compare and determine the applicability and feasibility of three different 3D-photography systems in clinical practice imaging the nose.Methods A total of 16 healthy non-operated noses were included in this prospective study. A plaster model of each nose was produced, digitized, and converted to a .stl mesh (= ground truth model). Three-dimensional images of each nose were then taken using Artec Space Spider (gold standard), Planmeca ProFace®, and the Bellus3D Dental Pro application. All resulting .stl files were aligned to the ground truth model using MeshLab software, and the root mean square error (RMSE), mean surface distance (MSD), and Hausdorff distance (HD) were calculated.Results The Artec Space Spider 3D-photography system showed significantly better results compared to the two other systems in regard to RMSE, MSD, and HD (each p < 0.001). There was no significant difference between Planmeca ProFace® and Bellus3D Dental Pro in terms of RMSE, MSD, and HD. Overall, all three camera systems showed a clinically acceptable deviation to the reference model (range: -1.23–1.57 mm).Conclusions The three evaluated 3D-photography systems were suitable for nose imaging in the clinical routine. While Artec Space Spider showed the highest accuracy, the Bellus3D Dental Pro app may be the most feasible option for everyday clinical use due to its portability, ease of use, and low cost. This study presents three different systems, allowing readers to extrapolate to other systems when planning to introduce 3D photography in the clinical routine.
Prognostics of multiple malaria episodes and nutritional status in children aged 6 to 59 months from 2013 to 2017 in Dangassa, Mali
Authors: Keita Soumba , Thiero Oumar , Toure Mahamoudou , Kane Fousseyni , Keita Moussa , Konate Drissa , Sanogo Daouda , Diawara Sory Ibrahim , Coulibaly Hamady , Thiam Sidibé M’Baye , Sogoba Nafomon , Diakite Mahamadou , Bamako Mali 
Published: November 2023

Abstract
Background
In Africa, the relationship between nutritional status and malaria remains complex and difficult to interpret in children. Understanding it is important in the development of malaria control strategies. This study evaluated the effect of nutritional status on the occurrence of multiple malaria episodes in children aged 6 to 59 months between 2013 and 2017 living in the village of Dangassa, Mali.
Methods
A community-based longitudinal study was conducted using cross-sectional surveys (SSCs) at the beginning (June) and end (November) of the malaria transmission season associated with passive case detection (PCD) at the Dangassa Community Health Center. Children with asymptomatic malaria infection during cross-sectional surveys were selected and their malaria episodes followed by PCD. Palustrine indicators in person-months were estimated using an ordinal-logistic model repeated on subjects during follow-up periods.
Results
The incidence rate (IR) during the period of high transmission (June to October), for 1 episode and for 2 + episodes peaked in 2013 with 65 children (IR = 95.73 per 1000 person-months) and 24 cases (IR = 35.35 per 1000 person-months), respectively. As expected, the risk of multiple episodes occurring during the period of high transmission was 3.23 compared to the period of low transmission after adjusting for other model parameters (95% CI = [2.45–4.26], p = 0.000). Children with anemia were at high risk of having multiple episodes (OR = 1.6, 95% CI [1.12–2.30], p = 0.011). However, the risk of having 2 + episodes for anemic children was higher during the period of low transmission (RR = 1.67, 95% CI [1.15–2.42], p = 0.007) compared to the period of high transmission (RR = 1.58, 95% CI [1.09–2.29], p = 0.016). The trend indicated that anemic and underweight children were significantly associated with multiple malaria episodes during the period of low transmission (p < = 0.001).
Conclusion
Our results indicate that multiple episodes of malaria are significantly related to the nutritional status (anemia and underweight) of the child during the two transmission seasons and more pronounced during the dry season (period of low transmission). Further research including other malnutrition parameters will be needed to confirm our findings.
Adalimumab as Therapy for Hidradenitis Suppurativa: a Systematic Review
Authors: Budianti Windy Keumala , Rakasiwi Muhammad Ilham Dhiya , Amin Ihya Fakhrurizal , Amelia Alda Zerlina 
Published: November 2023

Abstract
Background
Adalimumab (ADA) is a monoclonal antibody that is widely used as a biologic therapy for immune diseases, one of which is hidradenitis suppurativa (HS). To date, evidence-based therapeutic approaches have not been commonly used for standard of care and this is likely due to the lack of related research and the diverse therapeutic options. ADA biologic therapy shows satisfactory results and is approved by the FDA for moderate to severe HS in adult patients. Purpose: To provide an overview of the current evidence regarding the treatment of HS with ADA.
Methods
A literature search related to Hidradenitis Suppurativa Clinical Response (HiSCR) was performed on the PubMed, Scopus, and EbscoHost databases with an ADA focus on HS treatment to achieve HiSCR. Full text analysis of 8 RCT studies that met the inclusion and exclusion criteria and used a critically reviewed questionnaire from the CEBM University of Oxford.
Result
In this systematic review we obtained 8 RCTs for evaluation. The results showed that the prevalence of HiSCR after exposure to high doses of ADA, this statement was supported by 4 studies of RR > 1, meaning that the addition of ADA gave patients more opportunities to achieve HiSCR. Another finding was a decrease in Sartorius scores and DLQI after ADA treatment. ADA can reduce depressive symptoms and increase pain, this statement is supported by two studies using the PHQ and PGA-SP scores.
Conclusion
ADA has good efficacy against HS, as evidenced by the high prevalence of HiSCR and quality of life of patients.
On semi-continuity and continuity of the smallest and largest minimizing point of real convex functions with applications in probability and statistics
Authors: Ferger Dietmar 
Published: November 2023

Abstract
We prove that the smallest minimizer $\sigma(f)$ of a real convex function $f$ is less than or equal to a real point $x$ if and only ifthe right derivative of $f$ at $x$ is non-negative. Similarly, the largest minimizer $\tau(f)$ is greater or equal to $x$ if and only if the left derivativeof $f$ at $x$ is non-positive. From this simple result we deduce measurability and semi-continuity of the functionals $\sigma$ and $\tau$.Furthermore, if $f$ has a unique minimizing point, so that $\sigma(f)=\tau(f)$, then the functional is continuous at $f$. With these analytical preparations we canapply Continuous Mapping Theorems to obtain several Argmin theorems for convex stochastic processes. The novelty here are statements about classical distributional convergence and almost sure convergence, if the limit process does not have a unique minimum point. This is possible by replacing the natural topology on $\mathbb{R}$ with the order topologies. Another new feature is that not only sequences but more generally nets of convex stochastic processes are allowed.
Antibacterial Biocomposites: MWCNT-Coated Hanji Cellulose Paper against E. coli
Authors: Amjad Mufarah , Jeong Yunjo , Shin Subin , Kim Bogyeong , Kim Namyeon , Cho Hyunjin , Lee Sang Seok , Lee Sungbi , Na Wonjin , Jang Se Gyu , Moon SeonYoung , Lee Eun-Hee , Son Jangyup 
Published: November 2023

Abstract
Cellulose paper has been studied for its application as an antibacterial filter, due to its robust porous structure, minimal ecological footprint, biocompatibility, and inherent antibacterial properties. Moreover, its properties can be further enhanced via surface functionalization with metal nanoparticle (NP) agents such as silver, zinc, etc. However, the synthesis of metallic NP is challenging, costly, and environmentally harmful. On the other hand, carbon nanotubes are highly suitable as an additive to cellulose paper due to their high electrical conductivity, excellent mechanical strength, ease of fabrication, and antibacterial properties. In this study, we coated multi-walled carbon nanotubes (MWCNTs) on Hanji, a traditional Korean paper, using a simple dipping method and investigated its antibacterial activity against Escherichia coli (E. coli). The MWCNT-coated Hanji exhibited an inhibition efficiency of ~ 93% against E. coli cells. Moreover, the MWCNT coating resulted in improved mechanical strength, enhanced electrical conductivity, and increased hydrophobicity of the Hanji. Furthermore, it was observed that MWCNTs exhibited exceptionally stable adhesion to the Hanji surface. Our finding shows that MWCNT-coated Hanji could be utilized as an antibacterial material that is used as masks, air pollution filters, wallpapers in hospitals and residential complexes, and an efficient platform for antiviral studies.
Optimizing Sustainable High Performance Green Concrete Characteristics with Minimum Cement Content Using Response Surface Methodology
Authors: alani aktham , Johari Megat Azmi Megat , Majid T.A. , Bunnori N. Muhamad 
Published: November 2023

Abstract
In this study, an experimental design model based on the response surface method (RSM) was performed to identify the effect of optimum silica fume (SF) content on the development of compressive strength and rapid chloride permeability (RCP) of high-performance green concrete (HPGC) containing ultra-fine Palm Oil Fuel Ash (UPOFA). The UPOFA was used in ratios of (0%, 30%, and 60%) as a substitute binder for the mass of cement. SF was substituted by (0%,10, 15 and 20%) of the remaining mass of cement. The RSM with a central composite design (CCD) approach was utilized to optimize the mix design parameters. The results show that the responses (compressive strength and RCP) are influenced by the interaction of UPOFA and SF. Further, the developed models were statistically significant and exhibited a satisfactory correlation value (R2). Thus, the optimal condition was accurately predicted by the RSM method. Consequently, RSM as an optimization technique may be concluded to be a successful method for improving the mixture design. Based on this innovation, SF may expand the use of POFA in the production of green concrete with superior strength and high passive ion resistance. Meanwhile, reducing waste volume and costly power consumption for cement production.
Translation and validation of the revised “Rushton Moral Resilience Scale” in Greek
Authors: Katsiroumpa Aglaia , Moisoglou Ioannis , Konstantakopoulou Olympia , Tapaskou Theodosia , Gallos Parisis , Tsiachri Maria , Tsakalaki Anastasia , Galanis Petros 
Published: November 2023

Abstract
Background
High levels of moral resilience among nurses are crucial to maintain or restore moral integrity in response to moral challenges during their duties.
Aim
To translate and validate the revised “Rushton Moral Resilience Scale” (RMRS) in Greek.
Methods
We collected data from 316 nurses in Greece during July 2023. We translated the RMRS in Greek applying the forward-backward method and we adapted it in the Greek context. We used three other valid tools to estimate the concurrent validity of the RMRS: “Moral Distress Thermometer” (MDT) to measure levels of moral distress; “Quiet Quitting Scale” (QQS) to measure levels of quiet quitting; single item burnout measure to measure job burnout. We performed confirmatory factor analysis (CFA) to examine the construct validity of the RMRS.
Results
We found that the RMRS had excellent reliability since all intraclass correlation coefficients in test-rest reliability analysis were higher than 0.993 and statistically significant (p < 0.001). Moreover, Cronbach’s coefficients alpha for the response to moral adversity scale, personal integrity scale, relational integrity scale, moral efficacy scale, and total scale were 0.652, 0.795, 0.678, 0.640, and 0.778 respectively. Our confirmatory factor analysis confirmed the four-factors structure of the scale: response to moral adversity, personal integrity, relational integrity, and moral efficacy. Concurrent validity of the Greek version of the RMRS was exceptional since we found statistically significant correlations between the RMRS and MDT, QQS, and the single item burnout measure.
Conclusions
The revised “Rushton Moral Resilience Scale” is a reliable and valid tool to measure moral resilience in healthcare workers.
A review on medicinal and ethnomedicinal uses, biological features, and phytochemical constituents of Sesbania sesban L. Merr., a nitrogen-fixing plant native to the Republic of Chad
Authors: Mahamat Ousman Brahim , Younes Saoud , Otchom Boy Brahim , Franzel Steven , Hidjazi Al-Djazouli Ouchar Mahamat , Soumaya El Ismaili 
Published: November 2023

Abstract
This study reports on a literature review of the leguminous tree Sesbania sesban (L.) Merr, which is found in the N'Djamena region, the Republic of Chad. The study focused on S. sesban’s medicinal and ethnomedicinal uses, biological features, and phytochemical constituents to assist in future evaluations. A literature review using international academic websites, such as Science Direct, and Springer, plant databases, and data from national herbaria was conducted. S. sesban is a perennial shrub or tree that measures 3–4 meters in height. This species is becoming rare in Ndjamena but can be found in the gardens of some institutions in Ndjamena such as the Higher Institute of Educational Sciences (ISSED). The local inhabitants in Chad use the species as medicine, livestock feed, fuelwood, and for improving soil fertility and repelling desert encroachment. Traditional healers use its leaves to treat breast cancer and edema. S. sesban is an essential species native to the Republic of Chad that needs conservation and valorization. Viewing its rarity in N’Djamena today, a strategy for replanting the species in gardens, homes, and fields around Ndjamena and other regions of Chad is recommended.