bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Clinical Utility of Genetic Testing in the Diagnosis and Management of Adults with Chronic Kidney Disease
Authors: Dahl Neera K. , Bloom Michelle S. , Chebib Fouad T. , Clark Dinah , Westemeyer Maggie , Jandeska Sara , Zhang Zhiji , Milo-Rasouly Hila , Kolupaeva Victoria , Marasa Maddalena , Broumand Varshasb , Fatica Richard A. , Raj Dominic S. , Demko Zachary P. , Marshall Kyle , Punj Sumit , Tabriziani Hossein , Bhorade Sangeeta , Gharavi Ali G. 
Published: October 2023

Significance Statement
Accurate diagnosis of a patient's underlying cause of CKD can influence management and ultimately overall health. The single-arm, interventional, prospective Renasight Clinical Application, Review, and Evaluation study assessed the utility of genetic testing with a 385 gene kidney disease panel on the diagnosis and management of 1623 patients with CKD. Among 20.8% of patients who had positive genetic findings, half resulted in a new or reclassified diagnosis. In addition, a change in management because of genetic testing was reported for 90.7% of patients with positive findings, including treatment changes in 32.9%. These findings demonstrate that genetic testing has a significant effect on both CKD diagnosis and management.

Background
Genetic testing in CKD has recently been shown to have diagnostic utility with many predicted implications for clinical management, but its effect on management has not been prospectively evaluated.

Methods
Renasight Clinical Application, Review, and Evaluation RenaCARE (ClinicalTrials.gov NCT05846113) is a single-arm, interventional, prospective, multicenter study that evaluated the utility of genetic testing with a broad, 385 gene panel (the RenasightTM test) on the diagnosis and management of adult patients with CKD recruited from 31 US-based community and academic medical centers. Patient medical history and clinical CKD diagnosis were collected at enrollment. Physician responses to questionnaires regarding patient disease categorization and management were collected before genetic testing and 1 month after the return of test results. Changes in CKD diagnosis and management after genetic testing were assessed.

Results
Of 1623 patients with CKD in 13 predefined clinical disease categories (ages, 18–96; median, 55 years), 20.8% (n=338) had positive genetic findings spanning 54 genes. Positive genetic findings provided a new diagnosis or reclassified a prior diagnosis in 48.8% of those patients. Physicians reported that genetic results altered the management of 90.7% of patients with a positive genetic finding, including changes in treatment plan, which were reported in 32.9% of these patients.

Conclusions
Genetic testing with a CKD-focused 385 gene panel substantially refined clinical diagnoses and had widespread implications for clinical management, including appropriate treatment strategies. These data support the utility of broader integration of panels of genetic tests into the clinical care paradigm for patients with CKD.

Clinical Trial registry name and registration number
ClinicalTrials.gov, NCT05846113.
Amerikan Tiyatrosunda Arap Toplumuna Bakış: ‘Çeşitli Birleşim’ Oyununda Tektipleştirici Söylemlerde Niyet Okumak
Authors: ÖZSEVER Kenan 
Published: October 2023

Amerika çeşitli ırk, din ve etnik kökenden bireylerin oluşturduğu kozmopolit bir ülkedir. Bağımsızlığının ilanı ve uluslararası politikada ulus-devlet olarak tanınmasının ardından Amerika, özellikle 19. Yüzyıldan itibaren aldığı göçler neticesinde çok kültürlü bir topluma dönüşmüştür. Ancak bu çok kültürlü yapı, beyaz Amerikalılar (White Anglo-Saxon Protestant) tarafından zenginlik olarak değil, bir problem olarak görülmeye başlanmıştır. Beyaz Amerikalıların ulusal güvenlik sorunu olarak yorumladığı bu görüş günümüze değin varlığını sürdürmüş ve Amerikan toplumunda azınlıklara karşı tektipleştirici söylem ve tutumun ortaya çıkmasına neden olmuştur. Etnisite çeşitliliğine yönelik bu tektipleştirici yaklaşım birçok sanat alanında olduğu gibi tiyatro sanatında da karşılık bulmuş ve oyunlara konu olmuştur.
11 Eylül saldırılarının ardından Amerikan toplumunda bazı alışkanlıklar değişmeye başlamıştır. Ev buluşmaları ya da kapalı mekânlarda düzenlenen akşam yemeği partileri bu durumun en önemli göstergesidir. Çeşitli Birleşim (Omnium Gatherum) oyunu da saldırılar sonrası Amerika’da popüler hale gelen akşam yemeği partilerinin bir örneğinin temsilidir. Oyunda, Amerikalı bireylerin saldırılar sonrasındaki fikir ve görüşleri sorgulanmaktadır. Oyun kişileri, mikro ölçekli Amerikan toplumu görüntüsü sunan biyografik kişilerdir. Bu çalışma, Amerikan Tiyatrosu’nda 11 Eylül saldırılarının konu alındığı Çeşitli Birleşim oyunu ile sınırlıdır. Çalışmada çeşitli ırk, etnik köken ve sınıftan Amerikalıların saldırılar sonrası Araplara bakışındaki değişim ve bu değişimin Çeşitli Birleşim oyunundaki tezahürü ortaya konmaya çalışılacaktır.
Mind the Anterior Tibial Tendon in Oblique Distal Third Tibial Fractures with Anterior Inferior Proximal Spike
Authors: Bruce-Brand Robert , Wong-Chung John 
Published: October 2023

Case:
An oblique fracture of the distal third of the tibia, treated nonoperatively in a 14-year-old adolescent boy, did not unite because of ensnarement of the anterior tibial tendon (ATT) around an anterior inferior bony spike from the proximal tibial fragment. Computed tomography scan with 3-dimensional volume rendering aided in preoperative diagnosis. Surgical extraction of the tendon from within the fracture site and internal fixation led to successful union and full painless function.

Conclusion:
Beware of possible ATT entrapment as a cause of irreducibility of oblique distal third tibial fractures with an anterior inferior bony spike of the proximal fragment.
Representação de Atores Sociais nos desdobramentos de um Crime Corporativo
Authors: Magalhães Ferreira Pamella Thaís , Pereira Jussara Jéssica , Naves Flávia Luciana 
Published: October 2023

Objetivo da pesquisa: Compreender como a representação dos atores sociais no Termo de Transação e Ajustamento de Conduta (TTAC) do caso do rompimento da barragem de Samarco, em 2015, interfere no enfrentamento desse crime corporativo e influencia a ocorrência de outros similares.
Enquadramento teórico: O rompimento da barragem da Samarco é caracterizado como um crime corporativo (Medeiros; Silveira; Oliveira, 2018), assim, esse é o nosso principal enquadramento teórico. Ao mesmo tempo, num contexto tão conflituoso, o discurso tem papel central, por isso, utilizamos como referencial teórico e metodológico a Análise Crítica do Discurso de Norman Fairclough.
Metodologia: O presente trabalho utilizou como técnicas de coleta de informações a pesquisa bibliográfica e documental. As análises foram dadas a partir da Análise Crítica do Discurso do TTAC, abordando especificamente a representação dos atores sociais no referido documento.
Resultados: A representação dos atores sociais no TTAC legitima e sobrepõe os interesses da corporação aos interesses sociais, apaga as vítimas de seu lócus discursivo, levando a continuidade do domínio corporativo sobre o caso. Assim, a representação dos atores sociais no TTAC perpetua os fatores sociais que dão permissividade à ocorrência dos crimes corporativos.
Originalidade: Estudos sobre crimes corporativos tem enfatizado os efeitos negativos das ações corporativas. Contudo, observa-se um menor engajamento da literatura sobre os processos discursivos que envolvem os contextos desses crimes. Dessa forma, este artigo contribui com a elucidação desses processos discursivos, pois, o discurso corporativo de enfrentamento da crise ou instabilidade é parte de um processo de gerenciamento das impressões sobre a corporação, para criar e manter recursos de poder (Medeiros; Silveira; Oliveira, 2018)
Contribuições teóricas e práticas: Ao analisar o discurso como uma prática social contribui com a elucidação de estratégias utilizadas pelas corporações diante de um crime corporativo para manter seu poder hegemônico e ideológico na sociedade.
Investigating the attitude-behavior gap through the lens of pandemic:
Authors: Buhamra Abreu Romero Cláudia , Maria Calíope Sobreira Érica , Robson Moreira da Silva Clayton , Vicente Sales Melo Francisco 
Published: October 2023

Research objective: Our research seeks to study the gap between attitude and behavior during the pandemic. Considering the stay-at-home behavior as positive, we believed that all aspects of the attitudes would be unfavorable, since staying at home during the pandemic caused a series of discomfort to citizens, which configures an attitude-behavior gap.
Theoretical framework: The attitude-behavior gap is a phenomenon widely studied in psychology and marketing. The Theory of Rational Action (Azjen & Fishzbein, 1977) postulates that the individual's behavior derives from his/her attitude. When the individual’s behavior is inconsistent from s/he thinks or feels towards a behavior it is called the attitude-behavior gap. The Theory of Planned Action (Ajzen, 1991) explains the attitude-behavior gap based on the internal or external limitations imposed on the individual. In the present study, the attitude-behavior gap is brought to the context of the new coronavirus pandemic.
Methodology: We have developed a survey with 789 Brazilian citizens during the COVID-19 pandemic. Data were analyzed using exploratory factor analysis and descriptive statistics. Based on confirmatory factor analysis, four factors were extracted from the attitude scale, of which two factors represent affective responses (i.e., negative emotions and worry and fear) and two factors represent cognitive responses (i.e., safety and trust).
Results: The results confirmed the existence of the gap once individuals presented unfavorable attitudes regarding the behavior on an affective basis. However, the individuals showed favorable attitudes related to the imposed behavior to stay-at-home on a cognitive basis, demonstrating an attitude-behavior consistency, and not an attitude-behavior gap.
Originality: The investigation of attitudes towards the “stay at home” behavior in the light of the Theory of Rational Action and the Theory of Planned Action, aiming to identify a possible gap between the attitudes of individuals and the mandatory behavior “stay at home”.
Theoretical and practical contributions: As for managerial implications, the research shows the importance of the communication of governments, authorities, professionals, and policy makers to lower the citizens negative feelings and to inspire trust and safety in the society, especially in hard situations.
Efeitos do Controle Orçamentário Rígido no Empowerment Psicológico e Engajamento nas IFES do Brasil
Authors: Desconsi Sutero Débora , Flores Costa Vânia Medianeira , Costa da Silva Zonatto Vinícius 
Published: October 2023

Objetivo da pesquisa: Analisar os efeitos do controle orçamentário rígido no empowerment psicológico e engajamento no trabalho, na perspectiva de gestores públicos com responsabilidade orçamentária nas IFES brasileiras.
Enquadramento teórico: O modelo teórico testa as relações diretas do controle orçamentário rídigo e as dimensões de impacto, competência, significado e autodeterminação do empowerment psicológico, e as dimensões de vigor, dedicação e absorção do engajamento no trabalho.
Metodologia: Pesquisa descritiva, com abordagem quantitativa (MEE), foi operacionalizada mediante questionário aplicado a 253 gestores.
Resultados: Observou-se que o controle orçamentário rígido influencia de maneira distinta tais variáveis. Promove o impacto e a competência dos gestores, bem como seu engajamento no trabalho. Contudo, não é capaz de influenciar as dimensões de significado e autodeterminação do empoderamento. Estes gestores identificam sua influência no trabalho, mediante o impacto que a função orçamentária apresenta na gestão das IFES. Altos níveis de conhecimento nas rotinas e processos orçamentários também foram identificados, inferindo-se que as habilidades da gestão são suficientes para a realização das tarefas, mesmo frente às restrições orçamentárias. Por outro lado, a baixa autonomia e participação orçamentária limitada, reduzem o significado e a autodeterminação no trabalho, prejudicando o planejamento dos gestores na execução orçamentária, além de reduzir o empoderamento. Conclui-se que o vínculo com o controle orçamentário das Instituições torna os indivíduos mais envolvidos e comprometidos no trabalho.
Originalidade: A pesquisa inova ao analisar os efeitos das características do controle orçamentário rígido no empoderamento psicológico e no engajamento no trabalho, suprindo esta lacuna de pesquisa no contexto analisado.
Contribuições teóricas e práticas: Denota-se os efeitos das características da configuração orçamentária e seus reflexos consequentes em importantes aspectos cognitivos e comportamentais dos indivíduos no trabalho, apresentando avanços na literatura e contribuindo com as organizações ao conhecer fatores que motivam ou inibem a realização das tarefas de gestores com responsbilidade orçamentária.
Evaluation of major-ion chemistry for Niobrara River watershed, Nebraska, USA
Authors: Atkinson Jon C Atkinson 
Published: October 2023

Abstract

Examination of historical (1968–1991) aqueous geochemistry data [major cations and anions, pH, specific conductance, and total dissolved solids (TDS)] for 500 water samples provided by the Water Quality Portal maintained online by the US Environmental Protection Agency for the Niobrara River, a National Scenic River, and six tributary creeks, a reservoir, and two tributary rivers, located in northwestern and northcentral Nebraska, revealed that the mineralization (TDS) is relatively low. Calculated median TDS for the Niobrara River is 192 mg/L (n = 322); calculated median TDS for the tributary rivers and creeks is 129 mg/L (n = 181). Only a few sample analyses are not the Ca-HCO3 hydrochemical facies. The mineralization (salinity) level of Niobrara River water is essentially constant from upstream to downstream. Hydrochemical equilibrium modeling of the Niobrara River watershed (NRW) reveals that most samples occurred in an aqueous environment characterized by slight calcite and dolomite supersaturation and gypsum undersaturation; low supersaturation index values comprise a line of evidence for the thermodynamic equilibrium or near equilibrium of the NRW waters. Statistical analysis (one-way ANOVA) and graphical methods (e.g., Stiff diagrams, scatter plots) are used to characterize and interpret the hydrogeochemistry of the NRW. Scatter plots of meq/L concentrations of (Ca + Mg) versus (HCO3 + SO4) reveal the impact of silicate minerals (e.g., feldspar) weathering on the aqueous geochemistry throughout the watershed. These ubiquitous feldspar minerals most likely originated along the eastern slope of the Front Range during Late Cretaceous and Tertiary time (Laramide Orogeny).
A comparative study on the clinical efficacy of UBETlif and Mis-Tlif in the treatment of degenerative Lumbar Stenosis with Instability
Authors: Zhou yixuan , Zhang jianing , Liang Dingjie , qian weiqing 
Published: October 2023

Abstract

Purpose To compare the clinical efficacy of unilateral biportal endoscopic technique transforaminal lumbar interbody fusion (UBE-TLIF) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in treating degenerative lumbar stenosis with instability. Methods A retrospective study was performed on 64 patients with degenerative lumbar stenosis with instability admitted between January 2018 and December 2021 and divided into UBE-TLIF and MIS-TLIF groups. Comparison of data; surgical index; postoperative complications; the visual analogue scale (VAS) score for back pain and leg pain, Oswestry disability index (ODI), and MOS 36-Item Short-Form health survey (SF-36) were used to evaluate the function before surgery, 1 and 3 months after surgery, and at the last follow-up; and adult spinal deformity (ASD) at the last follow-up. Results All patients successfully completed the surgery, with a follow-up time of 6 to 16 months. There were no statistical differences in general data between groups. Reagarding surgical indicators: the UBE-TLIF group had more advantages in terms of intraoperative blood loss, surgical incision length, and postoperative hospital stay, although the operation time was longer. Regarding clinical efficacy evaluation indicators: the VAS, ODI, and SF-36 in both groups significantly improved at each time point after surgery, there was no difference in other time points. Compared with the MIS-TLIF group, there was no significant difference in the VAS or SF-36. The ODI of the UBE-TLIF group was better than the MIS-TLIF group 1 month after surgery, with no statistical difference at other time points. ASD incidence in both groups was 3.125%, the difference was not statistically significant. Conclusion Compared with MIS-TLIF, UBE-TLIF achieved a similar interbody fusion effect in the treatment of degenerative lumbar instability with spinal stenosis, optimised surgical indicators, and reduced postoperative stress response.
Laboratory test utilization before and after intervention in a secondary care Finnish geriatric inpatient hospital
Authors: Jääskeläinen Anniina , Heikkinen Elina 
Published: October 2023

Abstract
Background
Laboratory testing influences up to 60–70% of treatment decisions, yet overuse, underuse and misuse of diagnostic tests is common. The aim of this study was to improve the quality of laboratory testing in a secondary care hospital.
Methods
The study design was a prospective before and after setting. The data regarding ordered laboratory tests, sample collections, and laboratory penalty charges during 2013–2015 was collected and evaluated. Areas of improvement were identified and an intervention was designed including updating the electronic form for ordering laboratory tests, and organizing educational sessions for doctors followed by monthly short reminders of the topic. Laboratory utilization before and after the intervention was compared using logistic regression analysis. The effect of the intervention was followed up throughout 2016–2018.
Results
Laboratory testing before the intervention was unchanged in 2013–2015. The five most common analyses: complete blood count (CBC), C-reactive protein (CRP), blood creatinine (SCR), blood sodium and potassium, constituted 67.5% of all laboratory tests. Utilization of most common tests per patient (CBC, CRP, SCR, sodium, potassium, INR) was reduced statistically significantly after the intervention. The number on overall tests per bed day and per patient were discovered statistically significantly lower after the intervention along with sample collection. Most of the identified problems (the overuse of AST and FOBT, the underutilization of B12TC2) were corrected. Inappropriate test utilization, mix-up of tests, and use of outdated tests were identified and found to be unnecessarily costly. Laboratory test ordering decreased by 9.6% and sample collection by 7.2% in the year following the intervention due to the decrease in the number of the most ordered tests. No improvement was seen for laboratory tests usually ordered by nurses, as they were not included in the intervention.
Conclusions
Reduction of unnecessary laboratory testing was achieved by an intervention including two parts: education and changing the electronic ordering form. Continuous education of doctors was found to be an effective tool for efficient use of laboratory tests. Future interventions should include nurses.
Determination of N-acetyl-L-Cysteine and Glutathione by the colorimetric method with the use of a smartphone as a detector
Authors: Bevanda Anita Martinović , Arapović Anamarija , Vasilj Matej , Pušić Ante , Talić Stanislava , Ivanković Anita 
Published: October 2023

Abstract
The possibility of determining N-acetyl-L-cysteine or Glutathione based on the reaction with Cu(II)-neocuproine complex according to a simple procedure and using a spectrophotometer or a smartphone as detectors is described. The analytical applicability of the methods was tested and the excellent characteristics of the smartphone as a detector in the analysis of pharmaceuticals were observed. The prepared reaction solutions were yellow and their absorbance was measured at a wavelength of 450 nm. Also, due to the yellow color of the solution, the intensity of the blue RGB channel decreased with increasing thiol concentration. The proposed procedures allow the determination of both thiols in the linear dynamic range from 3.0×10− 6 to 2.0×10− 4 mol L-1 for a spectrophotometer as a detector, or from 6.0×10− 6 to 2.0×10− 4 mol L-1 for a smartphone as a detector. The obtained results indicate the usefulness of the CUPRAC method in the analysis of thiols, but also represent a smartphone as a comparable detector with a UV-Vis spectrophotometer.
Ecology of the extremely female-biased pest insect Hyperlasion breviantenna Sueyoshi et al., 2022 (Diptera: Sciaridae) occurring as outbreaks
Authors: Tagami Yohsuke , Ishihra Yuki , Ohata Yuta , Tsushima Yusuke , Sueyoshi Masahiro 
Published: October 2023

Abstract
Since approximately 2004, outbreaks of the sciarid species Hyperlasion breviantenna Sueyoshi et al., 2022, have occurred at Shizuoka University, Shizuoka, Japan. We attempted to identify the reason for the outbreaks through ecological research. According to the results of our investigation on the annual occurrence and ecological characteristics of this species, it occurs in various habitats only in the rainy season, and adults emerge only in the morning. These individuals were only females. From the studies of this species in Tajimi city, Gifu, Japan, both females and males of this species usually emerge at the soil of forest edges rather than inside forests. The areas of forest edges where males emerged were limited depending on place. Males and females with intact wings, but only females come to houses or buildings. Small woodlands, gardens, and parks are the areas of origin in urban areas. We show that outbreaks of these insect leads are rarely nuisances because of the many fascinating characteristics of these pests.
A new Approach to Identify Gene-Environment Interactions and Reveal New Biological Insight in Complex traits
Authors: Zhu Xiaofeng , Yang Yihe , Lorincz-Comi Noah , Li Gen , Bentley Amy , de Vries Paul , Brown Michael , Morrison Alanna , Rotimi Charles , Gauderman W. James , Rao Dabeeru , Aschard Hugues 
Published: October 2023

Abstract
There is a long-standing debate about the magnitude of the contribution of gene-environment interactions to phenotypic variations of complex traits owing to the low statistical power and few reported interactions to date. To address this issue, the CHARGE Gene-Lifestyle Interactions Working Group has been spearheading efforts to investigate G X E in large and diverse samples through meta-analysis. Here, we present a powerful new approach to screen for interactions across the genome, an approach that shares substantial similarity to the Mendelian randomization framework. We identified and confirmed 5 loci (6 independent signals) interacting with either cigarette smoking or alcohol consumption for serum lipids, and empirically demonstrated that interaction and mediation are the major contributors to genetic effect size heterogeneity across populations. The estimated lower bound of the interaction and environmentally mediated contribution ranges from 1.76–14.05% of SNP heritability of serum lipids in Cross-Population data. Our study improves the understanding of the genetic architecture and environmental contributions to complex traits.