bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Van Hove singularity systems in ternary borides
Authors: Sun Yang , Zhang Zhen , Porter Andrew P. , Kovnir Kirill , Ho Kai-Ming , Antropov Vladimir 
Published: October 2023

AbstractA computational search for stable structures among both α and β phases of ternary ATB4 borides (A = Mg, Ca, Sr, Ba, Al, Ga, and Zn, T is 3d or 4d transition elements) has been performed. We found that α-ATB4 compounds with A = Mg, Ca, Al, and T = V, Cr, Mn, Fe, Ni, and Co form a family of structurally stable or almost stable materials. These systems are metallic in non-magnetic states and characterized by the formation of the localized molecular-like state of 3d transition metal atom dimers, which leads to the appearance of numerous Van Hove singularities in the electronic spectrum. The closeness of such singularities to the Fermi level can be easily tuned by electron doping. For the atoms in the middle of the 3d row (Cr, Mn, and Fe), these singularities led to magnetic instabilities and magnetic ground states with a weakly metallic or semiconducting nature. Such states appear as non-trivial coexistence of the different spin ladders formed by magnetic dimers of 3d elements. These magnetic states can be characterized as an analog of the spin glass state. Experimental attempts to produce MgFeB4 and associated challenges are discussed, and promising directions for further synthetic studies are formulated.
‘Social’ versus ‘asocial’ cells—dynamic competition flux balance analysis
Authors: Liu Yanhua , Westerhoff Hans V. 
Published: October 2023

AbstractIn multicellular organisms cells compete for resources or growth factors. If any one cell type wins, the co-existence of diverse cell types disappears. Existing dynamic Flux Balance Analysis (dFBA) does not accommodate changes in cell density caused by competition. Therefore we here develop ‘dynamic competition Flux Balance Analysis’ (dcFBA). With total biomass synthesis as objective, lower-growth-yield cells were outcompeted even when cells synthesized mutually required nutrients. Signal transduction between cells established co-existence, which suggests that such ‘socialness’ is required for multicellularity. Whilst mutants with increased specific growth rate did not outgrow the other cell types, loss of social characteristics did enable a mutant to outgrow the other cells. We discuss that ‘asocialness’ rather than enhanced growth rates, i.e., a reduced sensitivity to regulatory factors rather than enhanced growth rates, may characterize cancer cells and organisms causing ecological blooms. Therapies reinforcing cross-regulation may therefore be more effective than those targeting replication rates.
Geoelectric characterisation of the junction of seismically active Delhi Hardwar Ridge and Delhi Sargodha Ridge
Authors: Rawat Gautam , Mohan Kapil , Dhamodharan S. , Dadhich Harendra , Chingtham Prasanta , Sain Kalachand , Mishra O. P. 
Published: October 2023

AbstractA magnetotelluric (MT) geophysical survey for the first time has been conducted for the geoelectric characterization of the junction of the contact zone of NNE-SSW striking Delhi Hardwar Ridge (DHR) and NW–SE trending Delhi Sargodha Ridge (DSR) in the Rohtak area, Haryana which has experienced 15 earthquakes of M2.0–M4.4 from April to August 2020. A total of 08 MT sites are acquired along a NW–SE profile of length 50 km. From the 2D MT data inversion, the DHR and DSR are for the first time characterized by equal values of moderate resistivity of 100 Ohm m at two depths. The resistivity variation for DHR corresponds to 100 Ohm m from the surface to the depth of 20 km, whilst DSR is found associated with the same value of resistivity extending in the NW direction. The DHR has been found striking NE-SW with a very shallow central axis (less than 400 m) having a width of 12–15 km forming half grabens on both limbs supported by shallow faults. The DSR has been found bifurcated from DHR at a depth of 12–13 km and extended in the NW direction. The DSR has been generated due to flexure bulging caused by collision and anticlockwise rotation of the Indian plate in the Eocene period. A NE striking steep dipping reverse fault (F1) has also been identified about 15 km west of the DHR. It is inferred that the DSR got upthrusted along this fault and became shallower in the NW region. The seismicity in the Rohtak and surroundings is located at the bifurcation points of DHR and DSR and the contact zone of DSR and reverse fault F1. The reverse fault F1 is also active and has generated microseismicity in the past.
Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway
Authors: El-Kafoury Bataa M. A. , Abdel-Hady Enas A. , El Bakly Wesam , Elayat Wael M. , Hamam Ghada Galal , Abd El Rahman Samar M. M. , Lasheen Noha N. 
Published: October 2023

AbstractThe utilization of digital technology has grown rapidly in the past three decades. With this rapid increase, cell phones emit electromagnetic radiation; that is why electromagnetic field (EMF) has become a substantial new pollution source in modern civilization, mainly having adverse effects on the brain. While such a topic attracted many researchers’ scopes, there are still minimal discoveries made regarding chronic exposure to EMF. The extensive use of cell phones may affect children's cognition even indirectly if parents and guardians used their phones repeatedly near them. This study aims to investigate possible lipoic acid (LA) effects on cognitive functions and hippocampal structure in young male rats exposed to electromagnetic fields (EMF) emitted from multiple cell phones. Forty young male Wistar rats were randomly allocated into three groups: control, multiple cell phones-exposed and lipoic acid-treated rats. By the end of the experimental period, the Morris water maze was used as a cognitive test. The rats were sacrificed for the collection of serum and hippocampal tissue. These serum samples were then utilized for assessment of Liver function tests. The level ofglutamate, acetylcholine (Ach) and malondialdehyde (MDA) was estimated, in addition to evaluating the expression of autophagy-related protein-7 (Atg7) and Sirt1 genes. The left hippocampal specimens were used for histopathological studies. Results showed that multiple cell phone-exposed rats exhibited shorter latency time to reach the platform by the fifth day of training; additionally, there was a reduction in consolidation of spatial long-term memory. Correspondingly, there was an elevation of hippocampal Ach, glutamate, and MDA levels; accompanied by up-regulation of hippocampal Sirt1 and Atg7 gene expression. Compared to the EMF-exposed group, LA administration improved both learning and memory, this was proved by the significant decline in hippocampal MDA and Ach levels, the higher hippocampal glutamate, the downregulated hippocampal Sirt1 gene expression and the upregulated Atg7 gene expression. In conclusion, EMF exposure could enhance learning ability; however, it interfered with long-term memory consolidation shown by higher hippocampal Ach levels. Lipoic acid treatment improved both learning and memory by enhancing autophagy and hippocampal glutamate level and by the reduced Ach levels and Sirt1 gene expression.
Neuroprotective effects of polyacrylic acid (PAA) conjugated cerium oxide against hydrogen peroxide- and 6-OHDA-induced SH-SY5Y cell damage
Authors: Meenambal Rugmani , Kruk Tomasz , Gurgul Jacek , Warszyński Piotr , Jantas Danuta 
Published: October 2023

AbstractCerium oxide nanoparticles have been widely investigated against neurodegenerative diseases due to their antioxidant properties that aid in quenching reactive oxygen species. In this study, polyacrylic acid conjugated cerium oxide (PAA-CeO) nanoparticles were synthesized in a 50–60 nm size range with a zeta potential of − 35 mV. X-ray photoelectron spectroscopy analysis revealed a mixed valence state of Ce4+ and Ce3+. PAA-CeO nanoparticles were safe for undifferentiated (UN-) and retinoic acid-differentiated (RA-) human neuroblastoma SH-SY5Y cells and reduced the extent of cell damage evoked by hydrogen peroxide (H2O2) and 6-hydroxydopamine (6-OHDA). In the H2O2 model of cell damage PAA-CeO did not affect the caspase-3 activity (apoptosis marker) but attenuated the number of propidium iodide-positive cells (necrosis marker). In the 6-OHDA model, nanoparticles profoundly reduced necrotic changes and partially attenuated caspase-3 activity. However, we did not observe any impact of PAA-CeO on intracellular ROS formation induced by H2O2. Further, the flow cytometry analysis of fluorescein isothiocyanate-labeled PAA-CeO revealed a time- and concentration-dependent cellular uptake of nanoparticles. The results point to the neuroprotective potential of PAA-CeO nanoparticles against neuronal cell damage induced by H2O2 and 6-OHDA, which are in both models associated with the inhibition of necrotic processes and the model-dependent attenuation of activity of executor apoptotic protease, caspase-3 (6-OHDA model) but not with the direct inhibition of ROS (H2O2 model).
Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector
Authors: Kise Satoko , Iijima Ayano , Nagao Chika , Okada Tadashi , Nishikawa Miyu , Ikushiro Shinichi , Nakanishi Tomoko , Sato Shigeto , Yasuda Kaori , Sakaki Toshiyuki 
Published: October 2023

AbstractType II rickets is a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. The main symptoms of this disease are bone dysplasia and alopecia. Bone dysplasia can be ameliorated by high calcium intake; however, there is no suitable treatment for alopecia. In this study, we verified whether gene therapy using an adenoviral vector (AdV) had a therapeutic effect on alopecia in Vdr-KO rats. The VDR-expressing AdV was injected into six 7-week-old female Vdr-KO rats (VDR-AdV rats). On the other hand, control-AdV was injected into 7-week-old female rats (control-AdV rats); non-infected Vdr-KO rats (control rats) were also examined. The hair on the backs of the rats was shaved with hair clippers, and VDR-AdV or control-AdV was intradermally injected. Part of the back skin was collected from each rat after AdV administration. Hair follicles were observed using hematoxylin and eosin staining, and VDR expression was examined using immunostaining and western blotting. VDR-AdV rats showed significant VDR expression in the skin, enhanced hair growth, and low cyst formation, whereas control-AdV and non-infected rats did not show any of these effects. The effect of VDR-AdV lasted for nearly 60 days. These results indicate that gene therapy using VDR-AdV may be useful to treat alopecia associated with type II rickets, if multiple injections are possible after a sufficient period of time.
Physical aspects of electro osmotically interactive Cilia propulsion on symmetric plus asymmetric conduit flow of couple stress fluid with thermal radiation and heat transfer
Authors: Akbar Noreen Sher , Muhammad Taseer 
Published: October 2023

AbstractA novel mathematical analysis is established that summits the key features of Cilia propulsion for a non-Newtonian Couple Stress fluid with the electroosmosis and heat transfer. In such physiological models, the conduit may have a symmetric or asymmetric configuration in accordance with the biological problem. Being mindful of this fact, we have disclosed an integrated analysis on symmetric in addition to asymmetric conduits that incorporates major physiological applications. The creeping flow inference is reviewed to model this realistic problem and exact solutions are computed for both the conduit cases. Graphical illustrations are unveiled to highlight the physical aspects of cilia propulsion on symmetric in addition to asymmetric conduit and an inclusive comparison study is conveyed. The flow profile attains higher values for an asymmetric conduit in relation to the symmetric. Likewise, the pressure rise and pressure gradient also score high for asymmetric conduit in relation to the symmetric conduit. A visual representation of flow inside symmetric as well as asymmetric conduit is provided by streamline graphs and temperature profile as well.
Toxicological investigation of lilial
Authors: Jablonská Eva , Míchal Zdeněk , Křížkovská Bára , Strnad Ondřej , Tran Van Nguyen , Žalmanová Tereza , Petr Jaroslav , Lipov Jan , Viktorová Jitka 
Published: October 2023

AbstractLilial (also called lysmeral) is a fragrance ingredient presented in many everyday cosmetics and household products. The concentrations of lilial in the final products is rather low. Its maximum concentration in cosmetics was limited and recently, its use in cosmetics products was prohibited in the EU due to the classification as reproductive toxicant. Additionally, according to the European Chemicals Agency, it was under assessment as one of the potential endocrine disruptors, i.e. a substance that may alter the function of the endocrine system and, as a result, cause health problems. Its ability to act as an androgen receptor agonist and the estrogenic and androgenic activity of its metabolites, to the best of our knowledge, have not yet been tested. The aim of this work was to determine the intestinal absorption, cytotoxicity, nephrotoxicity, mutagenicity, activation of cellular stress-related signal pathways and, most importantly, to test the ability to disrupt the endocrine system of lilial and its Phase I metabolites. This was tested using set of in vitro assays including resazurin assay, the CHO/HPRT mutation assay, γH2AX biomarker-based genotoxicity assay, qPCR and in vitro reporter assays based on luminescence of luciferase for estrogen, androgen, NF-κB and NRF2 signalling pathway. It was determined that neither lilial nor its metabolites have a negative effect on cell viability in the concentration range from 1 nM to 100 µM. Using human cell lines HeLa9903 and MDA-kb2, it was verified that this substance did not have agonistic activity towards estrogen or androgen receptor, respectively. Lilial metabolites, generated by incubation with the rat liver S9 fraction, did not show the ability to bind to estrogen or androgen receptors. Neither lilial nor its metabolites showed a nephrotoxic effect on human renal tubular cells (RPTEC/TERT1 line) and at the same time they were unable to activate the NF-κB and NRF2 signalling pathway at a concentration of 50 µM (HEK 293/pGL4.32 or pGL4.37). Neither lilial nor its metabolites showed mutagenic activity in the HPRT gene mutation test in CHO-K1 cells, nor were they able to cause double-strand breaks in DNA (γH2AX biomarker) in CHO-K1 and HeLa cells. In our study, no negative effects of lilial or its in vitro metabolites were observed up to 100 µM using different in vitro tests.
Expression signature of ten small nuclear RNAs serves as novel biomarker for prognosis prediction of acute myeloid leukemia
Authors: Zhang Zhongming , Huang Rui , Lai Yongrong 
Published: October 2023

AbstractThis study aimed to screen for small nuclear RNAs (snRNAs) associated with the prognosis of acute myeloid leukemia (AML) by using The Cancer Genome Atlas (TCGA) whole-transcriptome sequencing dataset. A total of 130 AML patients from TCGA cohort with complete prognostic information and transcriptome data were enrolled in the current study. Comprehensive survival and functional enrichment analyses were performed to explore the prognostic value and potential biological functions of prognostic snRNAs in AML patients. In the current study, we screened 72 snRNAs that were notably associated with the clinical outcome of AML and developed an expression signature consist of ten snRNAs, that can be accurately applied to assess the overall survival of AML patients. Functional mechanism analysis revealed that this expression signature may be strongly linked to some classical tumor-associated pathways, such as Notch and Wnt pathways, as well as being closely related to B and T cell receptor pathways. Furthermore, we screened six compounds (chicago sky blue 6 B, 5230742, clorsulon, nefopam, nicardipine, and streptomycin) that may serve as targeted therapeutic drugs for AML using connectivity maps. Tumor immunoassays indicated significant differences in the immune microenvironment of the bone marrow tissue between high-risk and low-risk AML patients. Immune infiltration analysis also revealed significant differences in the abundance of multiple immune cells in the bone marrow of the two groups of AML patients groups. In conclusion, our results revealed a novel prognostic expression signature of AML consisting of ten snRNAs, and we conducted a preliminary exploration of its potential biological functions and tumor immunity.
Research on point cloud hole filling and 3D reconstruction in reflective area
Authors: Sun Chao , Miao LongXin , Wang MeiYuan , Shi Jiuye , Ding JianJun 
Published: October 2023

Abstract3D reconstruction is the process of obtaining the three-dimensional shape or surface structure of an object, which is widely used in advanced manufacturing fields such as automotive, aerospace, industrial inspection, and reverse engineering. However, due to the structural characteristics of the component itself, the reflective properties of the coating material, and other factors, there may be specular reflection during image acquisition, making it difficult to achieve complete 3D reconstruction of the component. This paper proposes a method to address the problem of incomplete 3D reconstruction of strongly reflective objects by recognizing outlier points and filling point cloud holes. The proposed View-Transform-PointNet outlier point recognition network improves the alignment of the initial point cloud plane and implements secondary alignment of the point cloud based on the perpendicularity between the outlier plane in mixed reflection and the point cloud plane. The point cloud hole-filling method is based on the principle of outlier formation and approximates a local Gaussian distribution to linear variation. The distance between the end of each outlier plane and the real surface is calculated to repair the depth information of outlier points. The proposed method achieves a 39.4% increase in the number of point cloud filling, a 45.2% increase in the number of triangular mesh faces, a 46.9% increase in surface area, and a chamfer distance (CD) of 0.4471009, which is better than existing geometric repair methods in terms of standard deviation and smoothness. The method improves the alignment of initial point cloud planes and enhances the accuracy of outlier point recognition, which are the main innovative points of this study. The 3D reconstruction of the repaired point cloud model is achieved through Poisson equation and parameter adjustment. The proposed method reduces the error caused by large curvature in the boundary region and improves the smoothness and accuracy of the reconstructed model.
Exploring the promising application of Be12O12 nanocage for the abatement of paracetamol using DFT simulations
Authors: Gul Sana , Kainat  , Ali Qaisar , Khan Momin , Ur Rehman Munir , AlAsmari Abdullah F. , Alasmari Fawaz , Alharbi Metab 
Published: October 2023

AbstractThe removal of paracetamol from water is of prime concern because of its toxic nature in aquatic environment. In the present research, a detailed DFT study is carried out to remove paracetamol drug from water with the help of Be12O12 to eliminate the related issues. Three different geometries (CMP-1, CMP-2, CMP-3,) are obtained with the highest adsorption energies value (Eads) of − 31.2316 kcal/mol for CMP-3 without any prominent structural change. It is observed from the study that O atom from the carbonyl group (C=O) and H atom from O–H group successfully interact with O and Be atoms of the nanocage respectively. Natural bonding orbitals analysis reveals charge transfer to paracetamol drug from Be12O12 nanocage with maximum charge transfer of − 0.159 e for CMP-3 with bond angle of 1.65 Å confirming the stability of the CMP-3 among the optimized complexes. The quantum theory of atoms in molecule concludes that the interaction between paracetamol drug molecule and Be12O12 is purely closed-shell weak electrostatic in nature in CMP-1 and CMP-3 and shared interaction in CMP-2. The thermodynamics analysis witnesses that the process is exothermic and spontaneous. The regeneration study reveals the reversible nature of the adsorbent. The overall study presents Be12O12 nanocage as a potential adsorbent and may be used in future for the purification of water from a number of emerging pollutants.
The effect of short-term plants cultivation on soil organic/inorganic carbon storage in newly formed soils
Authors: Raheb Alireza , Asgari Lajayer Behnam , Senapathi Venkatramanan 
Published: October 2023

AbstractStudying total soil carbon (STC), which encompasses organic (SOC) and inorganic carbon (SIC), as well as investigating the influence of soil carbon on other soil properties, is crucial for effective global soil carbon management. This knowledge is invaluable for evaluating carbon sequestration, although its scope is currently limited. Boosting soil carbon sequestration, particularly in arid regions, has direct and indirect implications for achieving over four Sustainable Development Goals: mitigating hunger, extreme poverty, enhancing environmental preservation, and addressing global climate concerns. Research into changes within SOC and SIC across surface and subsurface soils was conducted on aeolian deposits. In this specific case study, two sites sharing similar climates and conditions were chosen as sources of wind-blown sediment parent material. The aim was to discern variations in SOC, SIC, and STC storage in surface and subsurface soils between Sistan and Baluchistan Province (with rapeseed and date orchard cultivation) and Kerman Province (with maize cultivation) in southeastern Iran. The findings highlighted an opposing pattern in SOC and storage concerning soil depth, unlike SIC. The average SOC content was higher in maize cultivation (0.2%) compared to date orchard and rapeseed cultivation (0.11%), attributed to the greater evolution of these arid soils (aridisols) in comparison to the other region (entisols). Conversely, SIC content in the three soil uses demonstrated minimal variation. The mean STC storage was greater in maize cultivation (60.35 Mg ha−1) than in date orchard (54.67 Mg ha−1) and rapeseed cultivation (53.42 Mg ha−1). Within the examined drylands, SIC, originating from aeolian deposits and soil processes, assumes a more prominent role in total carbon storage than SOC, particularly within subsurface soils. Notably, over 90% of total carbon storage exists in the form of inorganic carbon in soils.