bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2
Authors: Al Hamwi Ghazl , Namasivayam Vigneshwaran , Büschbell Beatriz , Gedschold Robin , Golz Stefan , Müller Christa E. 
Published: January 2024

AbstractPatients with idiopathic pulmonary fibrosis show a strongly upregulated expression of chemokine CXCL14, whose target is still unknown. Screening of CXCL14 in a panel of human G protein-coupled receptors (GPCRs) revealed its potent and selective activation of the orphan MAS-related GPCR X2 (MRGPRX2). This receptor is expressed on mast cells and − like CXCL14 − upregulated in bronchial inflammation. CXCL14 induces robust activation of MRGPRX2 and its putative mouse ortholog MRGPRB2 in G protein-dependent and β-arrestin recruitment assays that is blocked by a selective MRGPRX2/B2 antagonist. Truncation combined with mutagenesis and computational studies identified the pharmacophoric sequence of CXCL14 and its presumed interaction with the receptor. Intriguingly, C-terminal domain sequences of CXCL14 consisting of 4 to 11 amino acids display similar or increased potency and efficacy compared to the full CXCL14 sequence (77 amino acids). These results provide a rational basis for the future development of potential idiopathic pulmonary fibrosis therapies.
Two-photon excitation fluorescence microspectroscopy protocols for examining fluorophores in fossil plants
Authors: Stoneman Michael R. , McCoy Victoria E. , Gee Carole T. , Bober Katherine M. M. , Raicu Valerică 
Published: January 2024

AbstractFluorescence emission is common in plants. While fluorescence microscopy has been widely used to study living plants, its application in quantifying the fluorescence of fossil plants has been limited. Fossil plant fluorescence, from original fluorophores or formed during fossilization, can offer valuable insights into fluorescence in ancient plants and fossilization processes. In this work, we utilize two-photon fluorescence microspectroscopy to spatially and spectrally resolve the fluorescence emitted by amber-embedded plants, leaf compressions, and silicified wood. The advanced micro-spectroscope utilized, with its pixel-level spectral resolution and line-scan excitation capabilities, allows us to collect comprehensive excitation and emission spectra with high sensitivity and minimal laser damage to the specimens. By applying linear spectral unmixing to the spectrally resolved fluorescence images, we can differentiate between (a) the matrix and (b) the materials that comprise the fossil. Our analysis suggests that the latter correspond to durable tissues such as lignin and cellulose. Additionally, we observe potential signals from chlorophyll derivatives/tannins, although minerals may have contributed to this. This research opens doors to exploring ancient ecosystems and understanding the ecological roles of fluorescence in plants throughout time. Furthermore, the protocols developed herein can also be applied to analyze non-plant fossils and biological specimens.
Precise determination of molecular adsorption geometries by room temperature non-contact atomic force microscopy
Authors: Brown Timothy , Blowey Philip James , Sweetman Adam 
Published: January 2024

AbstractHigh resolution force measurements of molecules on surfaces, in non-contact atomic force microscopy, are often only performed at cryogenic temperatures, due to needing a highly stable system, and a passivated probe tip (typically via CO-functionalisation). Here we show a reliable protocol for acquiring three-dimensional force map data over both single organic molecules and assembled islands of molecules, at room temperature. Isolated cobalt phthalocyanine and islands of C60 are characterised with submolecular resolution, on a passivated silicon substrate (B:Si(111)-$$(\sqrt{3}\times \sqrt{3})R3{0}^{\circ }$$

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). Geometries of cobalt phthalocyanine are determined to a ~ 10 pm accuracy. For the C60, the protocol is sufficiently robust that areas spanning 10 nm × 10 nm are mapped, despite the difficulties of room temperature operation. These results provide a proof-of-concept for gathering high-resolution three-dimensional force maps of networks of complex, non-planar molecules on surfaces, in conditions more analogous to real-world application.
An all-in-one seismic phase picking, location, and association network for multi-task multi-station earthquake monitoring
Authors: Si Xu , Wu Xinming , Li Zefeng , Wang Shenghou , Zhu Jun 
Published: January 2024

AbstractEarthquake monitoring is vital for understanding the physics of earthquakes and assessing seismic hazards. A standard monitoring workflow includes the interrelated and interdependent tasks of phase picking, association, and location. Although deep learning methods have been successfully applied to earthquake monitoring, they mostly address the tasks separately and ignore the geographic relationships among stations. Here, we propose a graph neural network that operates directly on multi-station seismic data and achieves simultaneous phase picking, association, and location. Particularly, the inter-station and inter-task physical relationships are informed in the network architecture to promote accuracy, interpretability, and physical consistency among cross-station and cross-task predictions. When applied to data from the Ridgecrest region and Japan, this method showed superior performance over previous deep learning-based phase-picking and localization methods. Overall, our study provides a prototype self-consistent all-in-one system of simultaneous seismic phase picking, association, and location, which has the potential for next-generation automated earthquake monitoring.
Soil pore water evaporation and temperature influences on clay mineral paleothermometry
Authors: Ibarra Daniel E. , Evaristo Jaivime 
Published: January 2024

AbstractClay mineral isotope paleothermometry is fundamental to understanding Earth’s climate system and landscape evolution. Status quo methods, however, assume constant factors, such as formation temperature and water isotopic compositions, and ignore seasonality, soil water evaporation and depth-dependent temperature changes. We propose first-order modifications to address these factors and test them in a modeling framework using published data from various settings. Our forward model reveals that neglecting evaporation and seasonal soil temperature variability may lead to significant underestimations of clay formation temperatures, especially in Mediterranean settings. Our inverse model indicates that high-latitude Eocene clay formation temperatures were ~8 °C warmer than modern, while Eocene river sediments in the Sierra Nevada show evaporation-influenced trends, suggesting that previous paleoelevation estimates were underestimated. Our framework demonstrates that explicit consideration of soil pore water evaporation and temperature variability is necessary when interpreting clay mineral isotope data in the context of temperature, hydroclimate and elevation reconstructions.
You only label once: A self‐adaptive clustering‐based method for source‐free active domain adaptation
Authors: Sun Zhishu , Lin Luojun , Yu Yuanlong 
Published: January 2024

AbstractWith the growing significance of data privacy protection, Source‐Free Domain Adaptation (SFDA) has gained attention as a research topic that aims to transfer knowledge from a labeled source domain to an unlabeled target domain without accessing source data. However, the absence of source data often leads to model collapse or restricts the performance improvements of SFDA methods, as there is insufficient true‐labeled knowledge for each category. To tackle this, Source‐Free Active Domain Adaptation (SFADA) has emerged as a new task that aims to improve SFDA by selecting a small set of informative target samples labeled by experts. Nevertheless, existing SFADA methods impose a significant burden on human labelers, requiring them to continuously label a substantial number of samples throughout the training period. In this paper, a novel approach is proposed to alleviate the labeling burden in SFADA by only necessitating the labeling of an extremely small number of samples on a one‐time basis. Moreover, considering the inherent sparsity of these selected samples in the target domain, a Self‐adaptive Clustering‐based Active Learning (SCAL) method is proposed that propagates the labels of selected samples to other datapoints within the same cluster. To further enhance the accuracy of SCAL, a self‐adaptive scale search method is devised that automatically determines the optimal clustering scale, using the entropy of the entire target dataset as a guiding criterion. The experimental evaluation presents compelling evidence of our method's supremacy. Specifically, it outstrips previous SFDA methods, delivering state‐of‐the‐art (SOTA) results on standard benchmarks. Remarkably, it accomplishes this with less than 0.5% annotation cost, in stark contrast to the approximate 5% required by earlier techniques. The approach thus not only sets new performance benchmarks but also offers a markedly more practical and cost‐effective solution for SFADA, making it an attractive choice for real‐world applications where labeling resources are limited.
Association between Tubulointerstitial Nephritis and Uveitis Syndrome and Small-Vessel CNS Vasculitis: A Case of Polyautoimmunity
Authors: Grinstein Lev , Hecher Laura , Weiss Deike , Johannsen Jessika , Denecke Jonas 
Published: January 2024

Abstract
Introduction We report a case study of two male pediatric patients presenting with anterior uveitis and elevated renal function parameters. Both were diagnosed with tubulointerstitial nephritis and uveitis syndrome and subsequently developed diffuse cerebral symptoms such as headache, fatigue, and diziness.
Methods Magnetic resonance images (MRIs) of the brain showed T2-hyperintense lesions with and without gadolinium enhancement leading to brain biopsy and diagnosis of small-vessel central nervous system (CNS) vasculitis in both cases. Both patients were treated according to BrainWorks small-vessel vasculitis protocol and symptoms vanished over the course of treatment. Follow-up MRIs up to 12 months after initiation of therapy showed no signs of recurrence indicating a monophasic disease.
Conclusion Small-vessel CNS vasculitis can occur simultaneously to other autoimmune diseases (ADs) in the scope of polyautoimmunity. As clinical findings of CNS vasculitis are often unspecific, neurological symptoms in nonneurological ADs should be adressed thoroughly. Under suspicion of small-vessel CNS vasculitis brain biopsy is still the gold standard and only secure way of definitive diagnosis.
Sex Differences in the Histopathology of Acute Type A Aortic Dissections
Authors: Grewal Nimrat , Dolmaci Onur Baris , Klautz Robert JM , Poelmann Robert E. 
Published: January 2024

Abstract
Background Although sex-related differences in cardiovascular surgery outcomes have increasingly garnered attention in the past decades, knowledge about sex disparities in the pathophysiology of acute type A aortic dissections (ATAADs) remains sparse. In this study, we evaluate the histopathologic and atherosclerotic lesions in female and male ATAAD patients.
Methods A total of 68 patients were studied: 51 ATAAD patients (mean age: 62.5 ± 10.8 years; 49% women) and 17 control patients (mean age: 63 ± 5.5 years; 53% women). Cardiovascular risk factors were assessed clinically. Intimal and medial histopathological features were systematically evaluated in all.
Results Compared to the control group, all ATAAD patients showed significantly more elastic fiber pathology, mucoid extracellular matrix accumulation, smooth muscle cell nuclei loss, and overall medial degeneration (p < 0.0001). The tunica intima was significantly thinner in the ATAAD patients than in the control group (p < 0.023), with the latter exhibiting significantly more progressive atherosclerotic lesions than the former. No difference in medial vessel wall pathology was seen between female and male patients. As compared to male ATAAD patients, atherosclerotic lesions were more severe in female ATAAD patients, independent of age and the cardiovascular risk factor hypertension.
Conclusion All ATAAD patients had a significantly thinner tunica intima and significantly diseased tunica media compared to the control patients. Our results suggest that the severity of medial aortic pathology is not sex specific in ATAAD patients. Intimal differences between females and males could, however, be considered a potential risk factor for the development of an aortic dissection.
Conventional and Robot-Assisted Microvascular Anastomosis: Systematic Review
Authors: Susanto Benedictus A. , Aurelie Nadine , Nathaniel William , Atmodiwirjo Parintosa , Ramadan Mohamad R. , Djohan Risal 
Published: January 2024

Abstract
Background The complexity of plastic microsurgery yields many risks. Robot assistance has been sought to maximize outcome and minimize complications. Reportedly, it offers increased dexterity and flexibility with attenuated human flaws, such as tremors and fatigue. This systematic review will further investigate that claim.
Methods A systematic search was conducted for operative outcomes and operator experience of reconstructive plastic microsurgery compared between conventional and robot-assisted procedures. Data were summarized then meta-analyzed or qualitatively assessed and critically appraised to determine the difference robot assistance offers.
Results This review comprises four studies, mainly investigating robot-assisted microvascular anastomosis. Meta-analysis of anastomosis time reveals that robot assistance takes more time than conventional without offering substantial health-related improvements. However, it offers greater comfort, consistency, and flexibility for operators.
Conclusion Robot assistance lengthens operative times because of its relative lack of implementation and subsequent lack of experienced operators. Times were quick to be improved as repeated procedures were performed and technical complications can be resolved by more experience with robotic equipment. Furthermore, it generally offers better operator experience. Despite this, robot assistance does not offer a better health outcome compared with conventional anastomosis, although its benefits may lie in aesthetic outcomes instead. Exploration of that aspect as well as nonsummarizable health outcomes are the two primary limitations of this review that warrants further investigation into the subject.
Chemical Synthesis and Antitumor Evaluation of Chikusetsusaponin IVa Butyl Ester and Its Analogues
Authors: Cao Peng , Yang You , Zheng Jibin , Wang Yanxiao , Zhang Yiyue , Rong Jingjing , He Dongjuan , Wang Xiaotong , Zhang Liangliang , Xu Jianguang 
Published: January 2024

AbstractChikusetsusaponin IVa butyl ester (CS-IVa-Be) is a triterpene saponin that acts as a novel IL6R antagonist for inducing breast cancer cell apoptosis. However, the structure–activity relationship for this class of saponins remains unclear. Here, we report a gram-scale synthesis of CS-IVa-Be and the efficient preparation of eight of its analogues. CS-IVa-Be was demonstrated to have significant antitumor activities against MDA-MB-231, HepG2, and A549 cells. When one of the sugar residues at either the 3-OH or 28-COOH position of CS-IVa-Be was cleaved, or the length of the alkyl chain on the d-glucuronic acid residue of CS-IVa-Be was changed, these analogues showed varied inhibitory activities against the cancer cell lines. Notably, the carboxylic acid form of CS-IVa-Be exhibited a stronger antitumor activity against MDA-MB-231 cells. Furthermore, the carboxylic acid form of CS-IVa-Be inhibited MDA-MB-231 cell proliferation in a dose-dependent manner by arresting the cell cycle at the G2/M phase.
Solvent-Free Synthesis of α-Cyanophosphonates from β-Nitro­styrenes by Using a Deep-Eutectic Solvent Catalyst
Authors: Tavakol Hossein , Shi Min , Shamsaddinimotlagh Sima , Ranjbari Mohammad A. 
Published: January 2024

Abstractα-Cyanophosphonates, which are useful reagents for the Horner–Wittig reaction, were synthesized under solvent-free conditions by using a choline chloride–zinc chloride deep-eutectic solvent (DES) as a catalyst. This is only the second report on the synthesis of these compounds. In the previous report, diethyl trimethylsilyl phosphite was used as a reagent and TiCl4 as a catalyst, whereas in this study, both the reagent (triphenylphosphine) and the catalyst (choline chloride–zinc chloride DES) are cheaper, more readily available, and less harmful than those used in the previous work. Moreover, the process involves an interesting cascade reaction between a β-nitrostyrene and two equivalents of triphenyl phosphite, leading to the desired product by a new synthetic route. The products can be used in the pharmaceutical and agricultural industries, in addition to their synthetic applications in the preparation of α,β-unsaturated nitriles. The reactions were completed on using 20 mol% of DES at 80 °C in six hours. Ten different β-nitrostyrenes were synthesized in yields of 55–87% after purification. β-Nitrostyrenes containing electron-donating groups showed higher yields. The reaction failed when aliphatic or heteroaromatic nitroalkenes or β-nitrostyrenes with electron-withdrawing substituents were employed. Finally, three plausible mechanistic routes are proposed for the reaction, starting with the nucleophilic addition of triphenyl phosphite to the carbon, nitrogen, or oxygen atom in the α-position.
Multicomponent Reaction-Based Heteroannulations: A Direct Access to Fused Tetrazolo Piperazinones and 1,4-Diazepanones
Authors: Neochoritis Constantinos G. , Fotopoulou Eirini , Vasilakis Alexandros 
Published: January 2024

AbstractBy exploiting the chemistry of bifunctional isocyanides, straightforward, rapid, and scalable Ugi-tetrazole-based multicomponent reaction heteroannulations were developed. Our synthetic approach provides a series of diverse fused tetrazolo piperazinones and 1,4-diazepanones in just one step.
Directing Hydrogen Isotope Exchange with Aryl Carboxylic Acids
Authors: Kerr William J. , Mudd Richard J. , Reid Marc , Paterson Laura C. , Atzrodt Jens , Derdau Volker 
Published: January 2024

AbstractA highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.
When less is more: lower esophageal sphincter-preserving peroral endoscopic myotomy is effective for non-achalasia esophageal motility disorders
Authors: Perananthan Varan , Gupta Sunil , Whitfield Anthony , Craciun Ana , Cronin Oliver , O'Sullivan Timothy , Byth Karen , Sidhu Mayenaaz , Hourigan Luke F. , Raftopoulos Spiro , Burgess Nicholas G. , Bourke Michael J. 
Published: January 2024

Abstract
Background Non-achalasia esophageal motility disorders (NAEMDs), encompassing distal esophageal spasm (DES) and hypercontractile esophagus (HCE), are rare conditions. Peroral endoscopic myotomy (POEM) is a promising treatment option. In NAEMDs, unlike with achalasia, the lower esophageal sphincter (LES) functions normally, suggesting the potential of LES preservation during POEM.
Methods This retrospective two-center observational study focused on patients undergoing LES-preserving POEM (LES-POEM) for NAEMD. Eckardt scores were assessed pre-POEM and at 6, 12, and 24 months post-POEM, with follow-up endoscopy at 6 months to evaluate for reflux esophagitis. Clinical success, defined as an Eckardt score ≤3, served as the primary outcome.
Results 227 patients were recruited over 84 months until May 2021. Of these, 16 underwent LES-POEM for an NAEMD (9 with HCE and 7 with DES). The median pre-POEM Eckardt score was 6.0 (interquartile range [IQR] 5.0–7.0), which decreased to 1.0 (IQR 0.0–1.8; P<0.001) 6 months post-POEM. This was sustained at 24 months, with an Eckardt score of 1.0 (IQR 0.0–1.8; P<0.001). Two patients (12.5%) developed Los Angeles grade A or B esophagitis.
Conclusions LES-POEM for NAEMD demonstrates favorable clinical outcomes, with infrequent esophagitis and reintervention for LES dysfunction rarely required.
Retraction Note: Ruqyah and Its Use among Patients with Cancer
Authors: Çaksen Hüseyin 
Published: January 2024

RetractionThe above article published in Journal of Child Science in Volume 13, Number 01, e20–e27, on March 20, 2023 (DOI: 10.1055/s-0043-1764498), has been retracted as it is lacking scientific base.
DACA Aneurysm Presenting as Ischemic Stroke
Authors: Pratik Shah , Sangani Gordhan , Shrivastava Manish , Raut Tushar , Mundada Krishna 
Published: January 2024

AbstractAneurysms rarely present with features of ischemic stroke. The data on treatment of such strokes is limited. We present a case of multiple aneurysms and an ischemic stroke caused by distal anterior cerebral artery (DACA) aneurysm treated with flow diverter placement, the first case of endovascular treatment of DACA aneurysmal ischemic stroke reported to our knowledge.
Role of foreign direct Investment and political openness in boosting the eco-tourism sector for achieving sustainability
Authors: Shang Yunfeng , Yang Qin , Pu Yuanjie 
Published: January 2024

AbstractThis study aimed to examine the impact of China’s political openness index and foreign direct investment on its ecotourism index from 1985 to 2019. The findings revealed that a 1% rise in foreign direct investment had a long-term effect, increasing China’s sustainable tourism index by 0.01%. Furthermore, the political openness index played a significant role in boosting ecotourism in China over both short and long periods. A 1% increase in the political openness index corresponded to a 0.32 and 0.53% increase in China’s ecotourism index in the short and long term, respectively. Additionally, the financial openness index had a positive impact in the short and long term, with a 1% improvement resulting in approximately 0.24 and 0.23% increases in China’s ecotourism index. Key policies to advance eco-tourism in China include ensuring political stability, enhancing green financial markets through fintech and blockchain, and implementing poverty alleviation measures.