bluuebunny/crossref_metadata_2025_split huggingface dataset:
An elaborative discussion on the potentiality, functional characteristics, curative effects, antinutritional factors, processing, and industrial applications of faba beans (Vicia faba L.) as a versatile legume
Authors: Agrawal Swati , Panigrahi Chirasmita , Eri Rajaraman 
Published: October 2023

SummaryGlobally, 60% of protein consumption comes from plant‐based sources. By exploring the potential of plant‐based proteins and incorporating them into diverse food options, we can not only enhance the sustainability of our food systems but also contribute to a more balanced and environmentally conscious society. Due to the limited availability of conventional food proteins, there has been a persistent exploration for alternative legume sources for addressing the need for protein‐based foods. Faba bean is a type of pulse that stands out among other legumes due to its high protein content (26.1%) and dietary fibre (25.0%). Faba beans and their derivatives have been suggested as potentially beneficial foods for individuals with diabetes and hypertension. However, faba beans contain some antinutritional factors (ANFs). These antinutrients can have adverse effects on digestion and nutrient absorption. Various strategies like thermal and non‐thermal processing methods have been employed to reduce the ANF content and improve nutritional functionality in faba beans. The applications of faba beans and their potential as replacements for traditional ingredients in various food products are described. By utilising processed fava bean products, novel food formulations and applications can be created, catering to the growing demand for healthier and functional food options.
The prevalence of urinary incontinence and risk factors in menopausal women in Turkey: A systematic review and meta‐analysis
Authors: Karaçam Zekiye , Özsoy Sevgi , Özer Yurdal Nazlı Emel 
Published: October 2023

AbstractThis study was conducted to determine the prevalence and risk factors of urinary incontinence in menopausal women. This systematic review and meta‐analysis followed PRISMA and COSMOS‐E guidelines. The searches were conducted on 1–15 April, 2022 using PubMed, EBSCO, Embase, PsycINFO, DOAJ, Web of Science, DergiPark, Scopus, Turkish Medline, Turkish Citation Index, TR Index and National Thesis Center search engines. The keywords ‘menopause, climacteric, urinary incontinence, risk factors, prevalence’ were used in the searches. The risk of bias was assessed using the Critical Appraisal Checklist for cross‐sectional studies developed by the Joanna Briggs Institute. Data were synthesized by meta‐analysis, meta‐regression and narrative methods. Eleven studies published between 2012 and 2022 were included. The total sample size of the studies was 2531. In this meta‐analysis, the estimated rate of urinary incontinence in women aged 40–65 years was 46.9% (95% CI: 0.346–0.595), and this result was statistically significantly affected by the moderator variables risk of bias (Q = 8.76, p = 0.013) and urinary incontinence diagnostic tools (Q = 27.60, p < 0.001). The estimated stress urinary incontinence rate was 19.1% (95% CI: 0.130–0.271), urge urinary incontinence rate was 5.1% (95% CI: 0.020–0.124) and the mixed urinary incontinence rate was 13.4% (95% CI: 0.092–0.192). The risk factors affecting urinary incontinence were found to be advanced age, menopause, diabetes mellitus, constipation, obesity, history of urinary incontinence during pregnancy and the postpartum period, mode of delivery, four or more births, urinary tract infection, family history of urinary incontinence and genetic predisposition. This meta‐analysis revealed that urinary incontinence and its types are highly prevalent in women aged 40–65 years and that the prevalence is influenced by the quality of research and the type of diagnostic tool used in addition to many risk factors. Planning and offering appropriate health care services based on these results could contribute to the protection and improvement of women's health.
RETRACTED: Effects of application of the clinical nursing pathway on surgical site wound infection and postoperative complication rates in patients with total knee arthroplasty: A meta‐analysis
Authors: Han Jing , Liu Xin‐Ju 
Published: October 2023

AbstractThis study aimed to systematically evaluate the effects of clinical nursing on surgical site wound infections and postoperative complications in patients after undergoing total knee arthroplasty (TKA). Computerised searches of Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure, VIP and Wanfang databases were conducted from inception to August 2023 to collect randomised controlled trials (RCTs) on patients with TKA who received clinical nursing pathway interventions. Literature screening, data extraction and quality assessment of the included studies were performed independently by two researchers. The meta‐analysis was performed using Stata 17.0. A total of 14 RCTs with 1174 patients were included, including 587 patients each in the intervention and control groups. The meta‐analysis results showed that the application of clinical nursing pathways to patients undergoing TKA significantly reduced surgical site wound infections (risk ratio [RR] = 0.28, 95% confidence interval [CI]: 0.15–0.54, p < 0.001) and postoperative complications (RR = 0.25, 95% CI: 0.17–0.37, p < 0.001). Therefore, clinical nursing pathway interventions in patients undergoing TKA should be promoted in clinical practice as they can effectively reduce the incidence of wound infection and postoperative complications.
Case Report: Gianotti‐Crosti Syndrome Associated with Human Herpesvirus‐6 Infection
Authors: Yasumoto Shinichiro , Tsujita Jun , Imayama Shuhei , Hori Yoshiaki 
Published: October 2023

AbstractWe report a case of Gianotti‐Crosti syndrome associated with human herpesvirus‐6 (HHV‐6) infection. An eight‐month‐old girl developed monomorphous papules on her cheeks, buttocks, and extremities after the subsidence of exanthema subitum. Viral antibody analysis confirmed primary HHV‐6 infection. HHV‐6 may be added to the list of causative agents of Gianotti‐Crosti syndrome.
Domestication shapes the pig gut microbiome and immune traits from the scale of lineage to population
Authors: Kuthyar Sahana , Diaz Jessica , Avalos-Villatoro Fabiola , Maltecca Christian , Tiezzi Francesco , Dunn Robert R. , Reese Aspen T. 
Published: October 2023

AbstractAnimal ecology and evolution have long been known to shape host physiology, but more recently, the gut microbiome has been identified as a mediator between animal ecology and evolution and health. The gut microbiome has been shown to differ between wild and domestic animals, but the role of these differences for domestic animal evolution remains unknown. Gut microbiome responses to new animal genotypes and local environmental change during domestication may promote specific host phenotypes that are adaptive (or not) to the domestic environment. Because the gut microbiome supports host immune function, understanding the effects of animal ecology and evolution on the gut microbiome and immune phenotypes is critical. We investigated how domestication affects the gut microbiome and host immune state in multiple pig populations across five domestication contexts representing domestication status and current living conditions: free-ranging wild, captive wild, free-ranging domestic, captive domestic in research or industrial settings. We observed that domestication context explained much of the variation in gut microbiome composition, pathogen abundances and immune markers, yet the main differences in the repertoire of metabolic genes found in the gut microbiome were between the wild and domestic genetic lineages. We also documented population-level effects within domestication contexts, demonstrating that fine scale environmental variation also shaped host and microbe features. Our findings highlight that understanding which gut microbiome and immune traits respond to host genetic lineage and/or scales of local ecology could inform targeted interventions that manipulate the gut microbiome to achieve beneficial health outcomes.AbstractEcological and evolutionary facets of domestication shape gut microbiome composition and its functional potential as shown by clustering based on genetic lineage and husbandry practices.
Embryonic thermal manipulation of poultry birds: Lucrative and deleterious effects
Authors: Khalil Karim M. , El‐Shater Saad , Rizk Hamdy , Khalifa Elsayed 
Published: October 2023

AbstractThe major efforts to improve feed conversion, increase the body weight and breast muscle yield of broilers have been focused on feeding and management at the post hatch period. However, incubation temperature is the most significant factor for the egg hatching rate, chick quality, and post hatch performance. Therefore, incubation factors affecting the performance should be taken with necessary precautions. Incubation temperature not only affects the early development of the hatchlings but also has a lasting impact on the characteristics of the chicks, such as final body weight and meat quality traits. This article provides an overview about embryonic thermal manipulation (TM) of domestic fowls and review the lucrative and deleterious effects of embryonic TM on embryo development, muscle growth, thermotolerance acquisition, and immunity.
Total factor productivity and structural reforms: Evidence from advanced economies sector‐level data
Authors: Jalles João Tovar 
Published: October 2023

AbstractThis paper computes a new measure of capacity utilization‐adjusted Total Factor Productivity (TFP) using sector‐level data from a sample of 18 Advanced Economies and 24 industries between 1970 and 2014. We then empirically examine the impact of structural reforms (labor and product market) on TFP by means of the local projection method. Structural reforms follow a narrative‐base construction which have several advantages in our context. Results show that structural reforms positively impact TFP, particularly the liberalization of employment protection legislation for regular workers. The effect of reforms affects both changes in resource misallocation across sectors (the between effect) and within sectors (the within effect). The TFP‐effect of both types of reforms varies depending on the phase of the business cycle prevailing at the time the reform is implemented. Finally, our findings are robust to a wide range sensitivity checks.
At the core of the endomycorrhizal symbioses: intracellular fungal structures in orchid and arbuscular mycorrhiza
Authors: Perotto Silvia , Balestrini Raffaella 
Published: October 2023

SummaryArbuscular (AM) and orchid (OrM) mycorrhiza are the most widespread mycorrhizal symbioses among flowering plants, formed by distinct fungal and plant species. They are both endosymbioses because the fungal hyphae can enter inside the plant cell to develop intracellular fungal structures that are surrounded by the plant membrane. The symbiotic plant–fungus interface is considered to be the major site of nutrient transfer to the host plant. We summarize recent data on nutrient transfer in OrM and compare the development and function of the arbuscules formed in AM and the pelotons formed in OrM in order to outline differences and conserved traits. We further describe the unexpected similarities in the form and function of the intracellular mycorrhizal fungal structures observed in orchids and in the roots of mycoheterotrophic plants forming AM. We speculate that these similarities may be the result of convergent evolution of mycorrhizal types in mycoheterotrophic plants and highlight knowledge gaps and new research directions to explore this scenario.
Pre‐ and perinatal exposures associated with molar incisor hypomineralization: Birth cohort, Brazil
Authors: Franco Marcela M. P. , Ribeiro Cecilia C. C. , Ladeira Lorena L. C. , Thomaz Erika Bárbara Abreu Fonseca , Alves Claudia Maria Coelho 
Published: October 2023

AbstractObjectiveTo analyze prenatal and perinatal stressors associated with molar incisor hypomineralization (MIH) in adolescents.MethodsProspective cohort study collected prenatal (socioeconomic status, maternal age, number of prenatal visits, smoking, obesity during pregnancy, abortion history, gestational hypertension) and perinatal stressors (type of delivery, gestational age, birth weight, intensive care unit‐ICU at birth). The outcome was MIH at 18–19 years follow‐up (n = 590). MIH was defined according to the Ghanim criteria – Model I. We performed a sensitivity analysis, including opacities demarcated in index tooth, incisive or molars, Model II. Through structural equation modeling, we analyzed direct and mediating pathways between multiple stressors with outcomes.ResultsMIH was observed in 15.25% (n = 90), and opacities demarcated in any index tooth were observed in 22.8% of adolescents (n = 135). In Model I, no stressor explained MIH significantly, although we watched high standardized coefficients (SC) for low birth weight (SC = 0.223, p = 0.147), lower gestational age (SC = 0.351; p = 0.254), and ICU admission (SC = 0.447, p = 0.254). In Model II, advanced maternal age (SC = 0.148; p < 0.05) and not undergoing prenatal care (SC = 0.384, p < 0.03) explained opacities demarcated in incisors or molars.ConclusionAdvanced maternal age and not undergoing prenatal care were associated with MIH lesion‐like in incisors or molars.
Urbanization impacts short‐ but not long‐distance natal dispersal in a common orb web spider
Authors: Bonte Dries , Rose Clémence , Bastiaensen Thomas , Jesper Bechsgaard Jesper , Bilde Trine , Dahirel Maxime , De Wolf Katrien , Thylys Hélène , Uytterschaut Tine , Vanthournout Bram 
Published: October 2023

Urban environments represent a theatre for life history evolution. Species able to survive in urban areas can adapt to the local and often divergent environmental conditions compared to rural or (semi‐)natural environments. Dispersal determines establishment, gene flow, and thus the potential for local adaptation. Since habitats in urban environments are highly fragmented, and showing substantial turnover, contrasting adaptive effects on dispersal are expected. Fragmentation selects against dispersal while patch turnover is expected to promote the evolution of dispersal.We here show both processes to act in concert when different scales are considered. Dispersal behavior of juvenile, lab‐reared garden spiders from three mid‐sized European cities were tested under standardized conditions. While long‐distance dispersal showed to be overall rare, short‐distance dispersal strategies increased with urbanization at small scales but declined when urbanization was quantified at large scales.We discuss the putative drivers behind these differences in natal dispersal and highlight its importance for urban evolution and ecology.
Zero‐fluoroscopy ablation with multielectrode pulse field ablation system: Case series
Authors: Rauber Martin , Manninger Martin , Eberl Anna‐Sophie , Scherr Daniel 
Published: October 2023

AbstractPulse field ablation (PFA) is a novel nonthermal ablation modality for treatment of atrial fibrillation. While mostly lacking 3D electroanatomical mapping integration, reported radiation doses in procedures using multielectrode PFA catheters are relatively high. We report a first case series of three patients where a zero‐fluoroscopy approach by intracardiac echocardiography was utilized and present a possible workflow for zero‐fluoroscopy ablation with the Farapulse PFA system.
Measuring the construct of public sector creativity: Development of a validated scale
Authors: Houtgraaf Glenn , Kruyen Peter , van Thiel Sandra 
Published: October 2023

AbstractPublic sector creativity—public servants coming up with novel and useful ideas—is the origin of solutions and innovations central to public sector organizations' ability to optimally serve society's interests. Despite its relevance and argued limitations, an adequate scale and framework to assess public servants' creativity remained absent. Using three quantitative (n = 2434/n = 1157/n = 621) and two qualitative datasets, this state‐of‐the‐art preregistered study provides a novel, valid, reliable, comprehensive but succinct multidimensional measurement tool allowing detailed assessment of states and changes of public servants' creativity by academics and practitioners. To aid academics and practitioners' understanding of the scale and public sector creativity, it also provides a supplementary theoretical framework in line with the data structure of the scale that compresses and structures extant theory on creativity while emphasizing what is indicated as important in the public sector. The findings shed light on the nature of public sector creativity as an aggregate and multidimensional construct.
Revised nucleic acid test window periods: Applications and limitations in organ donation practice
Authors: Dutch Martin , Cheng Anthea , Kiely Philip , Seed Clive 
Published: October 2023

AbstractBackgroundNucleic acid test window periods for HIV, HCV, and HBV facilitate estimation of the residual risk of unexpected disease transmission and assist clinicians in determining the timeframe in which a recently acquired infection is at risk of nondetection.ObjectivesFirstly, to provide revised estimates of the NAT window periods based on a currently used triplex NAT assay. Secondly, to examine their validity in organ donation and transplantation practice.MethodEstimates were based on the Procleix Ultrio Elite Assay (Grifols Diagnostic Solutions Inc. California, USA). The manufacturer's X50 and X95 limits of detection (LOD) were utilised. Viral doubling times of 0.85, 0.45, and 2.56 days and conversion factors for IU per ml to copies per mL of 0.6, 3.4, and 5 were assumed for HIV, HCV, and HBV respectively. Window periods were derived from the X50 and X95 LODs, based on a range of potential inoculum volumes.ResultsCalculated X50 window periods were 5.1 (4.5–5.8), 2.7 (2.4–2.9), and 16.6 (14.2–19.1) days for HIV, HCV, and HBV respectively.Calculated X50 window periods, based on
whole body plasma volume, were 11.8 (10.3–13.3), 6.2
(5.6–6.8) and 36.7 (31.3–42.1) days respectively.ConclusionX50 NAT window periods were significantly shorter for HBV and HCV and sit at the lower range of previously published estimates for HIV . Current modeling assumptions may not account for all unexpected transmission events and may no longer be suitable for application to organ donation and transplantation.
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Assessing the post hoc effectiveness of tixagevimab−cilgavimab for prevention of SARS‐CoV‐2 infections in solid organ transplant recipients
Authors: Jordan Stanley C. , Joung Sandy Y. , Wang Minhao , Tran Teresa Anh , Bravo Michelle , Masoom Hibah , Chang Christine , Mendez Marilyn , Sun Nancy , Patel Jignesh , Kittleson Michelle , Frias Edwin , Prostko John C. , Ebinger Joseph E. , Cheng Susan , Sobhani Kimia 
Published: October 2023

AbstractBackgroundTixagevimab−cilgavimab (Tix‐Cil) was authorized for prophylaxis against COVID‐19 in immunocompromised patients from December 2021 through January 2023. Real‐world effectiveness for solid organ transplant (SOT) recipients has been unclear.MethodsWe enrolled 911 SOT recipients into a longitudinal COVID‐19 serology study, of whom 381 (42%) received ≥1 dose of Tix‐Cil. We collected and analyzed data on incident SARS‐CoV‐2 infections and antibody kinetics for all patients from January 2022 to March 2023, including periods dominated by Omicron BA and BQ subvariants.ResultsOver 253 ± 131 days of follow‐up, there were 324 new‐onset SARS‐CoV‐2 infections: 117 (31%) in Tix‐Cil treated and 207 (39%) in Tix‐Cil untreated patients (p = .012). In analyses adjusting for demographic, clinical, and COVID‐19 exposure factors, any Tix‐Cil treatment was associated with lower infection risk (OR 0.52, 95% CI 0.27–0.96, p = .039) throughout the surveillance period including when more resistant BQ.1 and BQ.1.1 subvariants had emerged (12/1/2022 onwards). Among treated patients, receiving a Tix‐Cil dose was associated with substantial and sustained increase in anti‐spike IgG antibody and angiotensin‐converting enzyme 2 binding inhibition levels (Abbott Architect assay) that together also demonstrated association with lower infection risk (p = .042). During the full surveillance period, the frequency of infections requiring hospitalization was low overall (N = 26, 2.9% of the total cohort) and not significantly different between Tix‐Cil recipients (N = 12, 3.2% of treated patients) and non‐Tix‐Cil recipients (N = 14, 2.6% of untreated patients) with unadjusted p = .31 for between‐group difference.ConclusionIn a large cohort of SOT recipients, we found that Tix‐Cil reduced infection risk even amidst emergent Omicron subvariants. Additionally, the extent of measurable humoral response to Tix‐Cil may indicate relative effectiveness. Pre‐exposure monoclonal antibody therapy may represent a strategy that will continue to offer clinical benefit for immunocompromised persons who are known to derive limited protection from vaccinations.
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A new Caenorhabditis elegans model to study copper toxicity in Wilson disease
Authors: Catalano Federico , O'Brien Thomas J. , Mekhova Aleksandra A. , Sepe Lucia Vittoria , Elia Mariantonietta , De Cegli Rossella , Gallotta Ivan , Santonicola Pamela , Zampi Giuseppina , Ilyechova Ekaterina Y. , Romanov Aleksei A. , Samuseva Polina D. , Salzano Josephine , Petruzzelli Raffaella , Polishchuk Elena V. , Indrieri Alessia , Kim Byung‐Eun , Brown André E. X. , Puchkova Ludmila V. , Di Schiavi Elia , Polishchuk Roman S. 
Published: October 2023

AbstractWilson disease (WD) is caused by mutations in the ATP7B gene that encodes a copper (Cu) transporting ATPase whose trafficking from the Golgi to endo‐lysosomal compartments drives sequestration of excess Cu and its further excretion from hepatocytes into the bile. Loss of ATP7B function leads to toxic Cu overload in the liver and subsequently in the brain, causing fatal hepatic and neurological abnormalities. The limitations of existing WD therapies call for the development of new therapeutic approaches, which require an amenable animal model system for screening and validation of drugs and molecular targets. To achieve this objective, we generated a mutant Caenorhabditis elegans strain with a substitution of a conserved histidine (H828Q) in the ATP7B ortholog cua‐1 corresponding to the most common ATP7B variant (H1069Q) that causes WD. cua‐1 mutant animals exhibited very poor resistance to Cu compared to the wild‐type strain. This manifested in a strong delay in larval development, a shorter lifespan, impaired motility, oxidative stress pathway activation, and mitochondrial damage. In addition, morphological analysis revealed several neuronal abnormalities in cua‐1 mutant animals exposed to Cu. Further investigation suggested that mutant CUA‐1 is retained and degraded in the endoplasmic reticulum, similarly to human ATP7B‐H1069Q. As a consequence, the mutant protein does not allow animals to counteract Cu toxicity. Notably, pharmacological correctors of ATP7B‐H1069Q reduced Cu toxicity in cua‐1 mutants indicating that similar pathogenic molecular pathways might be activated by the H/Q substitution and, therefore, targeted for rescue of ATP7B/CUA‐1 function. Taken together, our findings suggest that the newly generated cua‐1 mutant strain represents an excellent model for Cu toxicity studies in WD.