bluuebunny/crossref_metadata_2025_split huggingface dataset:
The problem of calculating the prevalence of sexual dysfunction: a meta-analysis attending gender
Authors: Ramírez-Santos Javier , Cristóbal-Cañadas Delia , Parron-Carreño Tesifón , Lozano-Paniagua David , Nievas-Soriano Bruno José 
Published: February 2024

Abstract

Introduction
Sexuality is an integral part of human health, and sexual dysfunctions are prevalent issues that affect men and women. While reviews on sexual dysfunctions in various diseases have been conducted, overall data are scarce.

Objectives
To update the overall prevalence of sexual dysfunctions from available prevalence studies on both sexes.

Methods
We used a 2-phase selection process to include cross-sectional studies that were conducted on the adult population and published between 2017 and 2022. The extracted data were prevalence, methodology, sample size, and location. Sensitivity and subgroup analyses were conducted to assess heterogeneity.

Results
This review analyzed 4407 studies. Twenty-three met the established criteria: 9 on the male population and 14 on the female population. The meta-analysis included 7 articles on males and 13 on females. The prevalence of sexual dysfunction was 31% in men and 41% in women, with significant heterogeneity among the studies. Sociocultural differences and use of varying measurement methods were identified as the main factors contributing to heterogeneity. Subgroup analysis revealed decreased heterogeneity among studies that used the Female Sexual Function Index as a diagnostic tool for females.

Conclusions
The review highlights the notable variability in results due to methodological and geographic variations. Therefore, enhancing the training of professionals and standardizing the recording of patient data—through the Female Sexual Function Index and Male Sexual Health Questionnaire or by developing new ones for this purpose—could improve the consistency of research on sexual health.
What contributes to promote sexual health in cancer palliative care? A realist review
Authors: Donz Roxane , Russia Bruno , Barbaret Cécile , Braybrook Debbie , Perceau-Chambard Elise , Reverdy Thibaut , Economos Guillaume 
Published: February 2024

Abstract

Introduction
Sexuality is an important determinant of the overall health of a population and remains so at the end of life and in patients with advanced cancers. Despite the abundant literature on sexuality and intimacy, these topics have been rarely discussed in the context of cancer palliative care, and very few interventions to promote sexual health in patients undergoing cancer palliative care have been explored.

Objectives
In this study we sought to identify which factors and mechanisms contribute to promoting sexual health in cancer palliative care.

Methods
A realist review was performed according to the guidelines of the realist and meta-narrative evidence synthesis method guidelines. Articles published between January 2010 and June 2021 were searched in 4 databases. Records were screened for their relevance regarding a predefined list of context–mechanism–outcome (CMO) configurations. Abstracts were independently screened by 2 authors before the data were extracted from the full-text articles selected for inclusion. With the use of abductive and retroductive reasoning techniques, each article was examined for evidence of its contribution to one of the CMO configurations, which could be refined when relevant. The data were summarized according to the final CMO configurations.

Results
Of the 2056 articles identified, 38 articles were included in the review. The data reported in these articles contributed to 7 CMO hypotheses: (1) improving communication skills, (2) healthcare provider training, (3) reorganizing the patient environment in care settings or at home, (4) managing sexual symptoms and also general symptoms, (5 and 6) patient-centered counseling or couple counseling, and (7) lifting the taboo.

Conclusions
The findings reported here highlight various ways to improve sexual health for patients in cancer palliative care but are limited to genital cancers. Further research should consider all types of cancer rather than being restricted to genital cancers.
Influence of particle size and origin of field peas on apparent ileal digestibility of starch and amino acids and standardized ileal digestibility of amino acids when fed to growing pigs
Authors: Ibagon Jimena A , Lee Su A , Nyachoti C Martin , Stein Hans H 
Published: February 2024

AbstractThe objective was to test the hypothesis that particle size and origin of field peas influence the apparent ileal digestibility (AID) of starch, crude protein (CP), and amino acids (AA) and the standardized ileal digestibility (SID) of AA. Three sources of field peas were procured. One source was from the United States and two sources were from Canada. The U.S. source and one of the sources from Canada (i.e., Canada 1) were each divided into two batches and ground to achieve a target particle size of 250 or 450 µm, whereas the other source from Canada (i.e., Canada 2) was only ground to a target particle size of 250 µm. Each batch of field peas was included in one diet as the only source of AA. An N-free diet was used to determine the basal endogenous losses of CP and AA. Six barrows (initial weight: 50.5 kg; SD = 3.7) that had a T-cannula installed in the distal ileum were randomly allotted to a 6 × 6 Latin square design with six diets and six 7-d periods. Ileal digesta from pigs were collected for 2 d after 5 d of adaptation. Data were analyzed using a statistical model that included batch of field peas as the fixed effect and animal and period as the random effects. Contrast statements were used to analyze the effects of particle size, origin, and the interaction between particle size and origin. Results indicated that the AID of starch was increased by reducing the particle size in the U.S. source of field peas, but that was not the case for the Canada 1 source (interaction; P &lt; 0.001). Particle size did not influence the AID of CP or AA, but the Canada 2 source of field peas had greater (P &lt; 0.05) AID of Trp, Ala, Cys, Gly, and Tyr than the field peas from the United States. The SID of CP and AA was also not affected by the particle size of field peas. The SID of CP and Trp was greater (P &lt; 0.05), and the SID of His, Ile, and Thr tended (P &lt; 0.10) to be greater in the Canada 2 source compared with the U.S. source, but no differences between the two Canada sources were observed. In conclusion, a few differences in SID of AA between field peas produced in the United States and peas produced in Canada were observed, but there was no effect on SID of AA of reducing the particle size of field peas from 450 to 250 µm, whereas the AID of starch increased by reducing the particle size only in the field peas from the United States.
Ecological and phylogenetic influences on limb joint kinematics in wild primates
Authors: Janisch Judith , McNamara Allison , Myers Lydia C , Schapker Nicole , Dunham Noah T , Phelps Taylor , Mundry Roger , Hieronymus Tobin , Shapiro Liza J , Young Jesse W 
Published: February 2024

Abstract
Arboreal locomotion is precarious and places multiple challenges upon stability. Studies have shown that captive primates respond to narrower and steeper supports by flexing limb joints and adopting a compliant gait. We tested whether these same kinematic responses are adopted by wild primates freely ranging over a variety of supports in their natural habitats. We recorded five species of platyrrhines, five species of catarrhines, and four species of strepsirrhines with modified GoPro cameras and used remote measurement to quantify substrate characteristics. Video images were imported into ImageJ to measure the angular kinematics of limb joints during quadrupedal locomotion on a variety of arboreal supports. We statistically tested for associations between joint posture and substrate characteristics, and then disentangled the influence of phylogeny and substrate on limb joint kinematics using variation partitioning and redundancy analysis. Our results partially confirm previous kinematic studies and suggest variation in support orientation, more than diameter or compliance, influences quadrupedal gait kinematics. Phylogenetic relatedness explained more variation in the data than substrate properties. This suggests primates either prospectively choose relatively ‘safe’ substrates for locomotion, or that they possess locomotor adaptations independent of limb joint kinematics per se to overcome the challenges of the precarious arboreal environment.
Cortistatin exerts an immunomodulatory and neuroprotective role in a preclinical model of ischemic stroke
Authors: Castillo-González J , Buscemi L , Vargas-Rodríguez P , Serrano-Martínez I , Forte-Lago I , Price M , Hernández-Cortés P , Hirt L , González-Rey E 
Published: February 2024

AbstractIschemic stroke is the result of a permanent or transient occlusion of a brain artery, leading to irreversible tissue injury and long-term sequelae. Despite ongoing advancements in revascularization techniques, stroke remains the second leading cause of death worldwide. A comprehensive understanding of the complex and interconnected mechanisms, along with the endogenous mediators that modulate stroke responses is essential for the development of effective interventions. Our study investigates cortistatin, a neuropeptide extensively distributed in the immune and central nervous systems, known for its immunomodulatory properties. With neuroinflammation and peripheral immune deregulation as key pathological features of brain ischemia, cortistatin emerges as a promising therapeutic candidate. To this aim, we evaluated its potential effect in a well-established middle cerebral artery occlusion (MCAO) preclinical stroke model. Our findings indicate that the peripheral administration of cortistatin at 24 hours post-stroke significantly reduces neurological damage and enhances recovery. Importantly, cortistatin-induced neuroprotection was multitargeted, as it modulated the glial reactivity and astrocytic scar formation, facilitated blood-brain barrier recovery, and regulated local and systemic immune dysfunction. Surprisingly, administration of cortistatin at immediate and early post-stroke time points proved to be not beneficial and even detrimental. These results emphasize the importance of understanding the spatio-temporal dynamics of stroke pathology to develop innovative therapeutic strategies. Premature interruption of certain neuroinflammatory processes might inadvertently compromise neuroprotective mechanisms. In summary, our study highlights cortistatin as a novel pleiotropic therapeutic approach against ischemic stroke, offering new treatment options for patients for whom early revascularization intervention is unsuccessful.Graphical abstract
ABCC10 roles in plant development and the transport of indole-3-butyric acid
Authors: Homayouni Arielle L. , Damodaran Suresh , Schreiber Katherine , Michniewicz Marta , Gunther Lauren K. , Strader Lucia C. 
Published: February 2024

ABSTRACTProper spatiotemporal distribution of the phytohormone auxin throughout plant tissues mediates a variety of developmental processes. Auxin levels are tightly regulated viade novosynthesis, transport, and conversion from its conjugated forms and precursors. These levels can be regulated through conversion of the auxin precursor, indole 3-butyric acid (IBA), into the active auxin, indole-3-acetic acid (IAA), in a peroxisomal β-oxidation process. Defects in IBA-to-IAA conversion cause multiple developmental defects in Arabidopsis, demonstrating IBA-derived IAA is physiologically important to the active auxin pool. Similar to IAA, transport of IBA modulates development. However, the mechanisms governing transport of this molecule remain largely unknown. Here, we identify a mutation in theABCC10gene of Arabidopsis that suppresses theabcg36hypersensitivity to IBA and its synthetic analog, 2,4-dichlorophenoxy butyric acid (2,4-DB) and theabcg36hyperaccumulation of [3H]-IBA. We found that ABCC10 acts as a direct vacuolar transporter of IBA. Further,ABCC10is necessary for proper development of the root apical meristem and leaf tissue. Our findings uncover a previously uncharacterized method of IBA transport that regulates aspects of plant development.
The intensity of supplementary feeding in an urban environment impacts overwintering MallardsAnas platyrchynhosas wintering conditions get harsher
Authors: Witkowska Marta , Wesołowski Wojciech , Markiewicz Martyna , Pakizer Jonasz , Neumann Julia , Ożarowska Agnieszka , Meissner Włodzimierz 
Published: February 2024

ABSTRACTAlthough urbanization poses various threats to avifauna, some bird species, including Mallards, are attracted to towns and cities as their winter habitats due to favourable temperatures and abundant anthropogenic food. In this study, we investigated how population dynamics changed in relation to winter harshness and intensity of supplementary feeding. The results indicated that the number of Mallards increased with the feeding intensity but the pattern differed in response to worsening of wintering conditions on water bodies with distinct supplementary feeding intensity. The ponds with low feeding intensity were occupied by fewer but more stable populations, suggesting the presence of natural food resources there, available for small number of individuals, regardless of winter conditions. On the ponds with medium feeding intensity, we observed a bell-shaped relationship between the number of ducks and ice cover. Unpredictable anthropogenic food on those ponds might not provide sufficient food resources, forcing birds to relocate when wintering conditions worsen. In such conditions, the ponds with a high feeding intensity attracted more ducks. We demonstrated that the wintering population of Mallards in urban areas is not solely influenced by ambient temperature but is also significantly affected by the intensity of supplementary feeding.
TheXanthomonas fragariaeeffector XopK suppresses stomatal immunity by perturbing abscisic acid accumulation and signaling pathways in strawberry
Authors: Cai Xiao-lin , Zhang Wenyao , Yu Haiyan , Wen Ying-qiang , Feng Jia-yue 
Published: February 2024

AbstractXanthomonas fragariae(Xaf) usually causes angular leaf spot (ALS) in strawberry all over the world. Recently, we isolated a new strain ofXafcalledXafYL19. This strain causes not only typical ALS symptoms, but also dry cavity rot in the crown tissues of strawberries. This was the first time aXafstrain had both of these effects in strawberries. Pathogen effectors play a crucial role in plant colonization and infection. Understanding how effector proteins escape from plant surveillance is important for plant breeding and resistance deployment. In this study, thirty-three putative effectors were predicted inXafYL19, and a virulent secreted effector called XopK was identified. XopK has a robust capacity for suppressing plant cell death and transcript response to infection host. Transgenic strawberries expressing XopK exhibit more susceptibility toXafYL19, and this was associated with weakened stomatal immunity. Additionally abscisic acid (ABA) accumulation and signaling were mainly suppressed in the presence of XopK. XopK also inhibited ABA- and methyl jasmonate (MeJA)-induced stomatal closure, and ABA- but not MeJA-induced reactive oxygen species (ROS) production. Moreover, endogenous ABA is critical forXaf-induced ROS burst and stomatal closure. These results suggested thatXafYL19 uses XopK to suppress JA, especially ABA signaling, for disrupting stomatal closure, and allowing its colonization for disease development. Taken together, our results provide a novel virulent mechanism byXafand an available strategy for resistant breeding in strawberries.
Enhancing Portability of Trans-Ancestral Polygenic Risk Scores through Tissue-Specific Functional Genomic Data Integration
Authors: Crone Bradley , Boyle Alan P. 
Published: February 2024

AbstractPortability of trans-ancestral polygenic risk scores is often confounded by differences in linkage disequilibrium and genetic architecture between ancestries. Recent literature has shown that prioritizing GWAS SNPs with functional genomic evidence over strong association signals can improve model portability. We leveraged three RegulomeDB-derived functional regulatory annotations - SURF, TURF, and TLand - to construct polygenic risk models across a set of quantitative and binary traits highlighting functional mutations tagged by trait-associated tissue annotations. Tissue-specific prioritization by TURF and TLand provide a significant improvement in model accuracy over standard polygenic risk score (PRS) models across all traits. We developed the Trans-ancestral Iterative Tissue Refinement (TITR) algorithm to construct PRS models that prioritize functional mutations across multiple trait-implicated tissues. TITR-constructed PRS models show increased predictive accuracy over single tissue prioritization. This indicates our TITR approach captures a more comprehensive view of regulatory systems across implicated tissues that contribute to variance in trait expression.
Internal structure ofMycoplasma mobilegliding machinery analyzed by negative staining electron tomography
Authors: Fukushima Minoru , Toyonaga Takuma , Tahara Yuhei O. , Nakane Daisuke , Miyata Makoto 
Published: February 2024

AbstractMycoplasma mobileis a parasitic bacterium that forms gliding machinery on the cell pole and glides on a solid surface in the direction of the cell pole. The gliding machinery consists of both internal and surface structures. The internal structure is divided into a bell at the front and chain structure extending from the bell. In this study, the internal structures prepared under several conditions were analyzed using negative-staining electron microscopy and electron tomography. The chains were constructed by linked motors containing two complexes similar to ATP synthase. A cylindrical spacer with a maximum diameter of 6 nm and a height of 13 nm, and anonymous linkers with a diameter of 0.9–8.3 nm and length of 5–30 nm were found between motors. The bell is bowl-shaped and features a honeycomb surface with a periodicity of 8.4 nm. The chains of the motor are connected to the rim of the bell through a wedge-shaped structure. These structures may play roles in the assembly and cooperation of gliding machinery units.SignificanceMycoplasma mobile, a parasitic bacterium, glides on solid surfaces at speeds of up to 4.0 μm per second through a specialized mechanism. The gliding machinery, located at one pole of the cell, is composed of surface legs and internal motor structures. The force generation unit within the internal structure evolved from ATP synthase. This study aimed to clarify the entire architecture of the gliding machinery using electron tomography.
Minimum Effective Dose of Clemastine in a Mouse Model of Preterm White Matter Injury
Authors: Odell Elizabeth , Jabassini Nora , Schniedewind Björn , Pease-Raissi Sarah E. , Frymoyer Adam , Christians Uwe , Green Ari J. , Chan Jonah R. , Ostrem Bridget E.L. 
Published: February 2024

ABSTRACTBackgroundPreterm white matter injury (PWMI) is the most common cause of brain injury in premature neonates. PWMI involves a differentiation arrest of oligodendrocytes, the myelinating cells of the central nervous system. Clemastine was previously shown to induce oligodendrocyte differentiation and myelination in mouse models of PWMI at a dose of 10 mg/kg/day. The minimum effective dose (MED) of clemastine is unknown. Identification if the MED is essential for maximizing safety and efficacy in neonatal clinical trials. We hypothesized that the MED in neonatal mice is lower than 10 mg/kg/day.MethodsMouse pups were exposed to normoxia or hypoxia (10% FiO2) from postnatal day 3 (P3) through P10. Vehicle or clemastine fumarate at one of four doses (0.5, 2, 7.5 or 10 mg/kg/day) was given orally to hypoxia-exposed pups. At P14, myelination was assessed by immunohistochemistry and electron microscopy to determine the MED. Clemastine pharmacokinetics were evaluated at steady-state on day 8 of treatment.ResultsClemastine rescued hypoxia-induced hypomyelination with a MED of 7.5 mg/kg/day. Pharmacokinetic analysis of the MED revealed Cmax44.0 ng/mL, t1/24.6 hours, and AUC24280.1 ng*hr/mL.ConclusionBased on these results, myelination-promoting exposures should be achievable with oral doses of clemastine in neonates with PWMI.Key PointsPreterm white matter injury (PWMI) is the most common cause of brain injury and cerebral palsy in premature neonates.Clemastine, an FDA-approved antihistamine, was recently identified to strongly promote myelination in a mouse model of PWMI and is a possible treatment.The minimum effective dose in neonatal rodents is unknown and is critical for guiding dose selection and balancing efficacy with toxicity in future clinical trials.We identified the minimum effective dose of clemastine and the associated pharmacokinetics in a murine chronic hypoxia model of PWMI, paving the way for a future clinical trial in human neonates.
ChineseEEG: A Chinese Linguistic Corpora EEG Dataset for Semantic Alignment and Neural Decoding
Authors: Mou Xinyu , He Cuilin , Tan Liwei , Yu Junjie , Liang Huadong , Zhang Jianyu , Yan Tian , Yang Yu-Fang , Xu Ting , Wang Qing , Cao Miao , Chen Zijiao , Hu Chuan-Peng , Wang Xindi , Liu Quanying , Wu Haiyan 
Published: February 2024

ABSTRACTAn Electroencephalography (EEG) dataset utilizing rich text stimuli can advance the understanding of how the brain encodes semantic information and contribute to semantic decoding in brain-computer interface (BCI). Addressing the scarcity of EEG datasets featuring Chinese linguistic stimuli, we present the ChineseEEG dataset, a high-density EEG dataset complemented by simultaneous eye-tracking recordings. This dataset was compiled while 10 participants silently read approximately 11 hours of Chinese text from two well-known novels. This dataset provides long-duration EEG recordings, along with pre-processed EEG sensor-level data and semantic embeddings of reading materials extracted by a pre-trained natural language processing (NLP) model. As a pilot EEG dataset derived from natural Chinese linguistic stimuli, ChineseEEG can significantly support research across neuroscience, NLP, and linguistics. It establishes a benchmark dataset for Chinese semantic decoding, aids in the development of BCIs, and facilitates the exploration of alignment between large language models and human cognitive processes. It can also aid research into the brain’s mechanisms of language processing within the context of the Chinese natural language.