bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cross-Sectional Study to Assess the Financial Hardships of Rural Households with Special Reference to COVID-19
Authors: Panchgaur Richa , Verma Ashish Kumar , Kumar Alok 
Published: October 2023

Abstract
The COVID-19 epidemic had an impact on the economic well-being of rural households, forcing them to adopt a new survival strategy. The Government of India also introduced several relief programmes to help the common people who were struggling financially as a result of the lockdown during the epidemic. The main objective of this paper is to assess the access of rural households to economic relief schemes and also the economic condition of rural households during the COVID-19 epidemic. The paper is based on a survey of 300 households in 30 villages of district Varanasi, Uttar Pradesh, India. We found a significant relationship between access to free ration and social category (χ2 = 7.27, p < 0.05) and to the level of education of the head of the household (χ2 = 15.94, p = 0.01). We also found that Scheduled Castes and Scheduled Tribes households experienced lack of ration or daily necessities ten times more than households of general category during the COVID-19 epidemic. Similarly, households of Other Backward Classes experienced lack of ration four times more than households of General category. There was substantial impact of COVID-19 epidemic on the financial status of rural households.
Quantitative errors in the Cochrane review on "Physical interventions to interrupt or reduce the spread of respiratory viruses"
Authors: Bar-Yam Yaneer , Samet Jon , Siegenfeld Alexander , Taleb Nassim 
Published: October 2023

Abstract
The COVID-19 pandemic has brought a heightened sense of urgency in the scientific community regarding the need to advance understanding and prevention of pathogen transmission, particularly concerning infectious airborne particles and the utility of various preventive strategies in reducing the risk of infection. There are extensive studies validating scientific understanding about the behavior of larger (droplets) and smaller (aerosols) particles in disease transmission and the dosimetry of particles in the respiratory track. Similarly, modalities for respiratory protection against particles in the size range spanned by infectious particles, such as N95 respirators, are available and known to be efficacious with tested standards for harm reduction across environments including physical, chemical and biological hazards. Even though multiple studies also confirm their protective effect when adopted in healthcare and public settings for infection prevention, overall, studies of protocols of their adoption over the last several decades in both clinical trials and observational studies have not provided as clear an understanding. Here we demonstrate that these studies are strongly biased towards the null by infections resulting from transmission outside of the investigated environments and study participants. Such study limitations are frequently mis-stated as not influencing the conclusions of research on respiratory protection. The reason for the failure to properly analyze the studies is that the standard analytical equations used do not correctly represent the random variables that play a role in the study results. By correcting the mathematical representation and the equations that result from them, we demonstrate that conclusions drawn from these studies are strongly biased and much more uncertain than is acknowledged, providing almost no useful information. Even with all these limitations, we show that existing results, when outcome measures are properly analyzed, consistently point to the benefit of precautionary measures such as N95 respirators over medical masks, and masking over its absence. We also show that correcting manifest errors of widely reported meta-analyses also leads to statistically significant estimates. Our results have implications for the design of studies and analyses on the effectiveness of respiratory protection and on using existing evidence for policy guidelines for infection control.
An Online Ensemble Method for Auto-scaling NFV-based Applications in the Edge
Authors: Silva Thiago Pereira da , Batista Thais Vasconcelos , Delicato Flavia C. , Pires Paulo F. 
Published: October 2023

Abstract

The synergy of edge computing and Machine Learning (ML) holds immense potential for revolutionizing Internet of Things (IoT) applications, particularly in scenarios characterized by high-speed, continuous data generation. Offline ML algorithms are unsuitable for data streams, as they require existing datasets to build prediction models. As an embodiment of ML, which embraces the fact that learning environments change over time, in Online Machine Learning (OML) the model is trained with each new observation in production time. Most OML algorithms are developed after the offline version and present different behaviors, considering bias and variance. Finding a suitable estimator to solve a ML problem is still a challenge. In this context, ensemble learning emerges as a promising approach for balancing the bias-variance tradeoff and improving prediction accuracy by aggregating outputs from multiple ML models. This paper introduces a novel ensemble method tailored for edge computing environments, designed to efficiently operate on resource-constrained devices while accommodating various online learning scenarios. The primary objective is to enhance predictive accuracy at the edge. We conducted extensive experimental evaluations to assess our proposed ensemble's predictive performance using synthetic and real datasets. Our ensemble outperformed state-of-the-art data stream algorithms and ensemble regressors across various regression metrics. Furthermore, we evaluated the ensemble's performance in the context of auto-scaling for Virtual Network Function (VNF)-based applications operating at the network's edge.
Recent Developments and Applications of Biocatalytic and
Chemoenzymatic Synthesis for the Generation of Diverse Classes of Drugs
Authors: Verma Swati , Paliwal Sarvesh 
Published: October 2023

Abstract:
Biocatalytic and chemoenzymatic biosynthesis are powerful methods of organic
chemistry that use enzymes to execute selective reactions and allow the efficient production of
organic compounds. The advantages of these approaches include high selectivity, mild reaction
conditions, and the ability to work with complex substrates. The utilization of chemoenzymatic
techniques for the synthesis of complicated compounds has lately increased dramatically in the
area of organic chemistry. Biocatalytic technologies and modern synthetic methods are utilized
synergistically in a multi-step approach to a target molecule under this paradigm. Chemoenzymatic techniques are promising for simplifying access to essential bioactive compounds because of the remarkable regio- and stereoselectivity of enzymatic transformations and the reaction diversity of modern organic chemistry. Enzyme kits may include ready-to-use, reproducible
biocatalysts. Its use opens up new avenues for the synthesis of active therapeutic compounds and
aids in drug development by synthesizing active components to construct scaffolds in a targeted
and preparative manner. This study summarizes current breakthroughs as well as notable instances of biocatalytic and chemoenzymatic synthesis. To assist organic chemists in the use of
enzymes for synthetic applications, it also provides some basic guidelines for selecting the most
appropriate enzyme for a targeted reaction while keeping aspects like cofactor requirement, solvent tolerance, use of whole cell or isolated enzymes, and commercial availability in mind.
The (Pro)renin Receptor - A Regulatory Nodal Point in Disease Networks
Authors: Funke-Kaiser Heiko , Unger Thomas 
Published: October 2023

Abstract:
Experimental inhibition of the (pro)renin receptor [(P)RR] is a promising therapeutic
strategy in different disease models ranging from cardiorenal to oncological entities. Here, we briefly
review the direct protein-protein interaction partners of the (P)RR and the plethora of distinct
diseases in which the (P)RR is involved.

:
The first structural work on the (P)RR using AlphaFold, which was recently published by Ebihara
et al., is the center of this mini-review since it can mechanistically link the protein-protein interaction
level with the pathophysiological level.

:
More detailed insights into the 3D structure of the (P)RR and its interaction domains might guide
drug discovery on this novel target. Finally, antibody- and small molecule-based approaches to inhibit
the (P)RR are shortly discussed.
Review of the Role of Metabolic Factors in Determining the Post-surgical
Adhesion and its Therapeutic Implications, with a Focus on Extracellular
Matrix and Oxidative Stress
Authors: Tavakkoli Mahmoud , Khodashahi Rozita , Aliakbarian Mohsen , Rahimi Hoda , Ashrafzadeh Kiarash , Ferns Gordon , Khaleghi Ebrahim , Arjmand Mohammad-Hassan 
Published: October 2023

Abstract:
The potential role of metabolic reprogramming in fibrogenesis has recently attracted interest. Extracellular matrix stiffness, inflammation, and
subsequent oxidative stress are essential mediators in the causation of fibrosis. The prevention of post-surgical adhesion is a challenge in medicine.
It is defined as a fibrotic disorder in which adhesive bands develop after abdominal or pelvic surgery. Despite many studies related to the
pathogenesis of post-surgical adhesion (PSA), many unknowns exist. Therefore, evaluating different pathways may help characterize and identify
the cause of fibrotic scar formation post-operation. Glucose and lipid metabolism are crucial metabolic pathways in the cell’s energy production
that may be targeted by hypoxia-induced factor alpha and profibrotic cytokines such as TGF-β to mediate fibrogenesis. Inhibition of upregulated
metabolic pathways may be a viable strategy for ameliorating post-surgical adhesion. In this review, we have discussed the potential role of altered
glucose and lipid metabolism in extracellular matrix (ECM) stiffness and oxidative stress as crucial mediators in fibrosis.
Antibacterial and Antimalarial Therapeutic Agents: A Patent Perspective
Authors: Zhang Hai-Long , Li Yongxia 
Published: October 2023

Background:
Antibacterial and antimalarial drugs play a critical role in combating
infectious diseases. It is a continuous work to develop new types of antibacterial and antimalarial
drugs.

Objectives:
To better understand current landscape and association of antibacterial and antimalarial
agents, the European patent analysis was performed.

Methods:
Antibacterial and antimalarial agents were analyzed by patent analysis. Patent documents
from January 2003 to May 2022 were retrieved and analyzed.

Results:
The present study indicated there were virtually three therapeutic approaches for antibacterial
agents, including chemical drugs, biological products and siRNA technology. Chemical
drugs were a mainstream therapeutic approach for development of both antibacterial and
antimalarial agents. However, the present study found that in contrast to antimalarials, siRNA
technology had been initially explored as therapeutic strategy for antibacterial agents. Also, our
study is the first to show that there is a low correlation between antibacterial and antimalarial
agents.

Conclusion:
Globally, our study is the first one to show that it may be not a fast approach to
discover antimalarial drugs from antibacterial agents based on drug repurposing. siRNA technology
as therapeutic strategy had been explored and used in antibacterial field.
A Home-Based Exercise Program With Active Video Games for Balance, Motor Proficiency, Foot and Ankle Ability, and Intrinsic Motivation in Children With Chronic Ankle Instability: Feasibility Randomized Controlled Trial
Authors: Chuadthong Janya , Lekskulchai Raweewan , Hiller Claire , Ajjimaporn Amornpan 
Published: October 2023

Abstract

Background
Children with chronic ankle instability (CAI) frequently experience ankle unsteadiness, causing trips, falls, and ankle sprain injuries resulting in poor quality of life. A specific exercise program focused on physical and psychological purposes in children with CAI is needed.

Objective
The purpose of this study was to investigate the feasibility of a 4-week home-based exercise training program using active video games (AVGs) for balance, motor proficiency, foot and ankle ability, and intrinsic motivation in children with CAI.

Methods
Sixty children with CAI (mean age 10, SD 2 years) were randomly assigned to an experimental group (AVG group; n=30) or a control group (CG; n=30). The AVG group played 2 selected video games, Catching Fish and Russian Block, while the CG received the traditional exercise program for CAI. Both programs were scheduled for 30 minutes per day, 3 times per week, for 4 weeks at home. The single-leg stance test was used to assess static balance. The walking forward on a line and standing long jump tests were used to assess motor proficiency. The Foot and Ankle Ability Measure (FAAM) and the Intrinsic Motivation Inventory questionnaire were used to assess foot and ankle ability and intrinsic motivation, respectively. Assessments were conducted at baseline and after 4 weeks.

Results
In the AVG group, the single-leg stand test (eyes open; on floor and on foam conditions), the FAAM (activities of daily living subscale), and intrinsic motivation (interest/enjoyment, pressure/tension, and value/usefulness dimensions) were improved compared with the CG (all P<.05). Motor proficiency did not differ between the 2 groups at the end of the 4-week program (P=.31 for the walking forward on a line, P=.34 for the standing long jump test).

Conclusions
A 4-week home-based exercise training program using AVGs can be beneficial and may be an effective approach for improving balance, foot and ankle ability, and enhancing positive motivation by increasing the interest/enjoyment and value/usefulness dimensions and lowering the pressure/tension dimension in children with CAI that require long-term rehabilitation sessions.
A mediação do engajamento no trabalho nas relações de recursos com o job crafting
Authors: Silva Louro Evania , Gabardo-Martins Larissa Maria David 
Published: October 2023

O Modelo de Demandas e Recursos do Trabalho preconiza a existência de relação positiva entre recursos e o job crafting, e a mediação do engajamento laboral. O presente trabalho objetivou compreender as relações do suporte social no trabalho (recurso do trabalho) e do medo de estar desconectado do trabalho (estado emocional) com o fator aumento de recursos do job crafting, além do papel mediador do engajamento laboral. A amostra compôs-se de 703 trabalhadores de diversas profissões e de ambos os sexos (90,6 % sexo feminino). Os resultados na modelagem de equações estruturais demonstraram que o suporte social no trabalho, o medo de estar desconectado do trabalho e o engajamento laboral relacionaram-se positivamente com o fator aumento de recursos do job crafting. O engajamento laboral mediou parcialmente a relação positiva do suporte social no trabalho e do medo de estar desconectado do trabalho com o fator aumento de recursos do job crafting. Tais resultados oferecem diferentes contribuições teóricas e práticas para a área da psicologia organizacional permitindo o avanço no conhecimento sobre a rede nomológica das relações do suporte social no trabalho e do medo de estar desconectado com o job crafting, tendo o engajamento como mediador.
ATUAÇÃO DO EMPRESARIADO NO NOVO ENSINO MÉDIO
Authors: Kossak Alex , Vieira Nelma 
Published: October 2023

O artigo analisa a atuação do empresariado no Novo Ensino Médio. No processo de recomposição burguesa, compreendemos que o empresariado tem atuado no sentido de direcionar as políticas educacionais e o Estado, como por exemplo, o movimento Todos Pela Educação. Utilizamos uma pesquisa de cunho documental, calcada no materialismo histórico-dialético para apontar que a atuação do capital privado tem sido no sentido de conformar a classe trabalhadora para as demandas de um mercado flexível e pragmático.
Palavra-chave: Novo Ensino Médio; Empresariado; Reforma Educacional; Todos Pela Educação.
ANALISIS PEMASARAN JAGUNG HIBRIDA DARI DESA TANG KECAMATAN BOKAT KABUPATEN BUOL
Authors: Trisudawan Trisudawan , Mappatoba Marhawati 
Published: October 2023

Jagung hibrida merupakan komoditi pertanian yang di usahatanikan oleh petani jagung yang ada di Desa Tang. Penelitian ini bertujuan menganalisis pemasaran jagung pada masing-masing saluran pemasaran jagung hibrida dari Desa Tang Kecamatan Bokat Kabupaten Buol. Penelitian dilaksanakan pada Bulan Desember 2019–Bulan Februari 2020. Data yang dikumpulkan terkait dengan pemasaran jagung hibrida dari Desa Tang Kecamatan Bokat Kabupaten Buol adalah data dalam satu kali musim panen (Juni–Oktober 2019). Penentuan responden pada penelitian ini dipilih dengan menggunakan metode sampel acak sederhana (simple random sampling), jumlah responden sebanyak 32 dari 121 populasi. Penentuan jumlah sampel dalam penelitian ini menggunakan rumus Slovin dengan tingkat kesalahan (e) sebesar 0,15 (15%). Analisis yang digunakan adalah analisis saluran pemasaran, bagian harga, margin pemasaran, margin total, efisiensi pemasaran. Hasil penelitian menunjukan dua tipe saluran pemasaran yaitu saluran pemasaran pertama : Petani Pedagang Pengumpul Pedagang Besar Konsumen, saluran pemasaran kedua : Petani Pedagang Besar Konsumen. Bagian harga yang diterima petani dari saluran pertama yaitu sebesar 78,57%, sedangkan pada saluran kedua yaitu sebesar 88,10%. Margin pemasaran yang diperoleh dari saluran pertama sebesar Rp.900 dan margin pemasaran pada saluran kedua yaitu Rp.500. Nilai efisiensi pemasaran yang diperoleh pada saluran pertama sebesar 11,71% dan untuk saluran pemasaran yang kedua diperoleh nilai efisiensi pemasaran sebesar 11,02%, deengan demikian dapat disimpulkan bahwa semakin pendek saluran pemasaran maka semakin besar bagian harga yang diterima petani demikian pula sebaliknya, dan semakin panjang saluran pemasaran maka margin pemasaran akan semakin besar demikian pula sebaliknya.
ANALISIS BEBERAPA SIFAT FISIK DAN KIMIA TANAH DI LAHAN TRANSMIGRASI PADA DAERAH TRANS SIDERA KECAMATAN SIGI BIROMARU KABUPATEN SIGI
Authors: Dudhayef Moh. , Baso Isrun , Pata’dungan Yosep Soge 
Published: October 2023

Berdasarkan data dari hasil penelitian maka dapat di peroleh kesimpulan sebagai berikut :
Sifat fisik dan kimia tanah pada penggunaan lahan sawah dengan pH rata-rata 5,93. Permeabilitas rata–rata 6,74 cm/jam. Porositas rata–rata 36,60. Bulk density rata–rata 1,51. N-total rata–rata 0,20%. P-total rata–rata 35,29 ppm. KTK rata–rata 20,70 mg/100 g. C-organik rata–rata 0,98%. K-total rata–rata 31,76%. Sifat fisk dan kimia tanah pada penggunaan lahan kelapa dengan pH rata–rata 6,63. Permeabilitas rata–rata 3,53 cm/jam. Porositas rata–rata 32,59%. Bulk density rata–rata 1,66. N-total rata–rata 0,07%. P-total rata–rata 28,65 ppm. KTK rata–rata 28,24 mg/100 g. C-organik rata–rata 1,48%. K-total rata–rata 30,21%. Sifat fisik dan kimia tanah pada penggunaan lahan Kakao PH rata–rata 6,28. Permeabilitas rata–rata 6,81 cm/jam. Porositas rata–rata 45,68%. Bulk density rata–rata 1,48. N-total rata–rata 0,18%. P-total rata–rata 26,95 ppm. KTK rata–rata 19,51mg/100 g. C-organik rata–rata 1,8%. K-total rata–rata 33,88%.
PENGARUH PUPUK KANDANG AYAM TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN JAGUNG PULUT (Zea mays certaina L.)
Authors: Tansidi Amina , Idham Idham , Syamsiar Syamsiar 
Published: October 2023

Tanaman jagung pulut merupakan komoditas pangan utama setelah padi yang mempunyai peranan strategis dalam pengembangan pertanian dan perekonomian di Indonesia. Namun adapun kendala-kendala produksi jagung pulut yang dihadapi yaitu penanaman varietas lokal secara terus menerus, pemupukan tidak sesuai dosis, serta teknik budidaya yang kurang maksimal. Salah satu cara untuk meningkatkan produksi jagung adalah menggunakan teknologi yang lebih baik, penggunaan bibit unggul, pengolahan tanah yang baik, pengaturan air irigasi yang baik, penggunaan pupuk kandang serta pemberantasan hama dan penyakit. Tujuan penelitian ini adalah: menentukan dosis pupuk kandang ayam yang terbaik untuk pertumbuhan dan produksi jagung pulut. Penelitian ini dilakukan pada bulan februari sampai dengan bulan juli 2020 di Desa Toliba Kecamatan Tojo Barat Kabupaten Tojo Una-Una Provinsi Sulawesi Tengah. Adapun alat dan bahan yang digunakan adalah handtraktor, cangkul, meteran, alat tulis menulis, kamera, bahan yang digunkan adalah benih jagung pulut arumba, dan pupuk kandang ayam. Penelitian ini disusun menggunakan Rancangan Acak Kelompok (RAK) Faktorial dengan satu faktor, yaitu : kosentrasi pupuk organik terdiri dari 6 taraf yaitu: P0= 0 kg/petak, P1= 6 kg/petak, P2= 9 kg/petak, P3= 12 kg/ petak, P4= 15 kg/petak, P5= 18 kg/petak sehingga terdapat 6 percobaan masing-masing perlakuan diulang 4 kali sehingga diperoleh 24 kali percobaan. Dosis pupuk kandang ayam 30 ton ha-1 yang terbaik untuk meningkatkan pertumbuhan dan produksi tanaman jagung pulut.
PENGARUH BERBAGAI KONSENTRASI BIO-URIN SAPI TERHADAP PERTUMBUHAN SETEK BATANG TANAMAN PURING (Codiaeum varigatum)
Authors: Fikri Moh.Andi , Muhardi Muhardi 
Published: October 2023

Tanaman puring telah lama dikenal oleh masyarakat Indonesia. Di Indonesia, tanaman yang memiliki daun dengan banyak corak warna ini ditanam sebagai penghias taman, untuk pagar, atau sebagai tanaman peneduh di makam-makam. Penelitian ini bertujuan untuk mengetahui pengaruh perendaman pada konsentrasi bio urin terhadap pertumbuhan stek tanaman Puring. Penelitian ini dilaksanakan di Kebun Percobaan Fakultas Pertanian, Universitas Tadulako, Palu. Waktu pelaksanaan penelitian ini di lakukan mulai bulan September–Desember 2019. Penelitian ini disusun menggunakan Rancangan Acak Kelompok (RAK) yang terdiri dari satu faktor, dngan perlakuan sebanyak lima taraf yaitu K0=(Kontrol), K1=50 ml/100ml air, K2=100 ml/100ml air, K3=150 ml/100ml air, K4=200 ml/100ml air, setiap perlakuan diulang 3 kali sehingga diperoleh 15 unit percobaan. Setiap satuan percobaan terdapat 3 tanaman sehingga terdapat 45 sampel tanaman yang diamati. Penelitian ini meliputi, jumlah tunas, jumlah daun, panjang akar, volume akar, dan persentase stek hidup. Hasil penelitian hanya terdapat satu yang berpengaruh nyata yaitu volume akar terhadap perlakuan bio urin sapi.