bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions and Predictors of Transition to Hospice for People Living with Dementia: An Integrative Review
Authors: Murali Komal Patel , Gogineni Srija , Bullock Karen , McDonald Margaret , Sadarangani Tina , Schulman-Green Dena , Brody Abraham A 
Published: February 2025

Abstract

Background and Objectives
Goal-concordant transition to hospice is an important facet of end-of-life care for people living with dementia. The objective of this integrative review was to appraise existing evidence and gaps focused on interventions and predictors of transition to hospice and end-of-life care for persons living with dementia across healthcare to inform future research.

Research Design and Methods
Using integrative review methodology by Whittemore and Knafl, five databases were searched (PubMed, CINAHL, Web of Science, Google Scholar, Cochrane Database for Systematic Reviews) for articles between 2000 and 2023. The search focused on dementia, hospice care, transitions, care management and/or coordination, and intervention studies.

Results
Fourteen articles met inclusion criteria after critical appraisal. Most were cross-sectional in design and conducted in nursing homes and hospitals in the U.S. persons living with dementia had multiple chronic conditions including cancer, diabetes, heart disease, and stroke. Interventions included components of hospice decision-making delivered through advance care planning, checklist-based care management for hospice transition, and palliative care for those with severe dementia. Predictors included increasing severity of illness including functional decline, organ failure, intensive care use, and the receipt of palliative care. Other predictors were related to insurance status, race and ethnicity, and caregiver burden. Overall, despite moderate to high-quality evidence, the studies were limited in scope and sample and lacked racial and ethnic diversity.

Discussion and Implications
Prospective, multisite randomized trials and population-based analyses including larger and diverse samples are needed for improved end-of-life dementia illness counseling and hospice care transitions for persons living with dementia and their caregivers.
Intestinal Ultrasound Identified Crohn’s Disease In Previously Undiagnosed Siblings
Authors: Krugliak Cleveland Noa , Bhondwe Khushi S , Duty Charlotte M , Rubin David T 
Published: February 2025

Lay Summary
We present the clinical cases of 3 brothers, 1 with confirmed diagnosis of Crohn’s disease (CD) and 2 with inconclusive findings by endoscopy and histology and demonstrate the utility of intestinal ultrasound in confirming the diagnosis of CD.
On Normed 𝔼∞-rings in Genuine Equivariant Cp-spectra
Authors: Yang Lucy 
Published: February 2025

Abstract
Genuine equivariant homotopy theory is equipped with a multitude of coherently commutative multiplication structures generalizing the classical notion of an $ {{\mathbb{E}}}_\infty $-algebra. In this paper we study the $ C_{p} $-$ {{\mathbb{E}}}_\infty $-algebras of Nardin–Shah with respect to a cyclic group $ C_{p} $ of prime order. We show that many of the higher coherences inherent to parametrized algebras collapse; in particular, they may be described more simply and conceptually in terms of ordinary $ {{\mathbb{E}}}_\infty $-algebras as a diagram category which we call normed algebras. Our main result provides a relatively straightforward criterion for identifying $ C_{p} $-$ {{\mathbb{E}}}_\infty $-algebra structures. We visit some applications of our result to real trace theories.
GABA-induced monocytic reactive oxygen species impair CD4 restoration in treated HIV-1 adults
Authors: Younas Mehwish , Gimenez Sandrine , Lin Yea-Lih , Mettling Clément , Maiorano Domenico , Reynes Jacques , Pasero Philippe , Rondard Philippe , Psomas Christina K , Corbeau Pierre 
Published: February 2025

Abstract

Background
In order to better understand why about 15% of people living with Human Immunodeficiency Virus-1 (PWH) on highly active antiretroviral therapy do not restore their CD4 count, we explored the link previously reported between glutamate plasma level and CD4 count.

Methods
We recruited fourty-four adults living with HIV-1 aviremic under antiretroviral therapy. Their peripheral blood concentrations in glutamate and GABA were determined by ELISA. Flow cytometry was used to detect GABA receptor, reactive oxygen species (ROS) produced by monocytes, and programmed T cell death. DNA-dependent protein kinase (DNA-PK) and p53 phosphorylation were analyzed by western blot. DNA damage was quantified by immunofluorescence.

Results
We show that i) some virologic responders present high plasma levels of glutamate and of its derivative, GABA; ii) monocytes express the GABA receptor GABA-B1; iii) GABA-B1 stimulation induces monocytic ROS production; iv) GABA-B1-overexpressing monocytes of PWH with high plasma levels of GABA release high amount of ROS; and v) monocyte-derived ROS oxidise the DNA of CD4+ T cells, creating double-strand breaks which activate DNA-PK and p53, and finally apoptosis. The intensity of this cascade of events is inversely correlated with the slope of CD4+ T cell recovery in treated PWH.

Discussion
We propose that DNA damage resulting from ROS produced by GABA-activated monocytes plays a key role in impaired immune restoration. Consequently, GABA-B1 antagonists and/or ROS inhibitors might be a promising therapy for non-immunologic responders. Furthermore, the same mechanism could be involved in CD4 loss in the natural course of the infection.
Fecal Microbiota-based Investigations of Nitrogen Utilization Efficiency and related Traits in a Landrace x Piétrain crossbred Population
Authors: Schmid Markus , Haas Valentin P , Sarpong Naomi , Rodehutscord Markus , Seifert Jana , Camarinha-Silva Amélia , Bennewitz Jörn 
Published: February 2025

Abstract
Improving protein efficiency in pork production is a desired goal regarding resource conservation and climate protection, whereby animal breeding has great potential for sustainable improvements. Nitrogen utilization efficiency (NUE) is an important trait but laborious to measure. As blood urea nitrogen (BUN) can be used to predict NUE, it is often used as indicator trait. Both NUE and BUN were found to be heritable, however, microbial studies have not yet been carried out. The present study aimed to investigate the role of the gastrointestinal microbiota in the context of N efficiency in different fattening phases. The dataset consisted of 450 Landrace x Piétrain pigs fattened in a two-phase feeding regime. All pigs were fecal sampled and phenotyped in two fattening phases, referred to as sampling period (SP) 1 and SP2 in week 13 and week 16 post natum, respectively. Microbial communities in feces were compared across SPs and significant differences were observed. Mixed linear models were applied to quantify the microbial variance and microbiability for NUE, BUN, and related traits within each of the SPs. Except for NUE in SP1, all microbiabilities were significant and ranged from 0.079 to 0.471. Microbiome-wide association studies revealed a polymicrobial trait architecture, characterized by the contribution of many genera, with each genus having a relatively small effect on the traits. In total, four and eleven microbial genera were significantly associated with NUE and BUN, respectively. Microbial correlations were estimated between traits within SPs via bivariate analyses. Blood urea nitrogen was significantly correlated with N intake and retention in SP1 but not in SP2. Fecal microbiota composition differed significantly between SPs and the use of microbiota data across SPs resulted in a remarkable drop in microbiability for nearly all traits. This implies that microbiota data should be representative of the time point of phenotyping to fully capture microbial contribution to trait expression. The results suggest that jointly using genomic and fecal microbial data might be expedient to improve protein efficiency in fattening pigs.
Genomics of liver abscesses in feedlot cattle
Authors: Hess Melanie K , McDermott Rebecca L , Erickson Galen E , Spangler Matthew L 
Published: February 2025

Abstract
The primary reason livers are condemned is due to abscesses, which are visible lesions detected on the liver during routine harvest of the animal. Condemned livers are deemed not fit for human consumption, and result in over $15M in lost income to the U.S. beef industry each year. Liver scoring is a 4-level measurement of abscess severity: 0 (no abscesses), A- (mild: 1-2 small abscesses), A (moderate: 2-4 active abscesses) and A+ (severe: 1 or more large, active abscesses). We quantified the degree to which known sources of variation, including genomic differences among animals, contribute to the incidence of liver abscesses in 1747 feedlot cattle fed a range of diets. Diets were grouped based on corn type (dry-rolled corn (DRC), high-moisture corn (HMC), DRC/HMC or steam-flaked Corn (SFC)) and byproduct (none, modified distillers grains plus solubles (MDGS), and Sweet Bran fed at 20%, 35% or 40%). A common set of SNP (n= 44,666) from the Illumina BovineSNP50 v2 and GGP Bovine 100K were used for genomic analyses. The posterior mean (posterior standard deviation) heritability estimate of liver score was 0.10 (0.05). Within-diet heritability estimates were not significantly different from zero but ranged from 0.02 (0.02) (MDGS) to 0.29 (0.32) (Sweet Bran fed at 35%). A BayesB Genome Wide Association Study with showed that liver score is a very polygenic trait with no large QTL segregating in this population. The genetic and phenotypic correlations of liver score with hot carcass weight, 12th rib fat, longissimus muscle area, or marbling score were not significantly different from zero. Results from the current study show that genomic selection for reduced liver score could be a useful tool to reduce the occurrence of liver abscesses in feedlot cattle, alongside current mitigation strategies; however, more data is needed to gain a better understanding of the genetic basis of liver score, as well as the relationship between liver score and other economically relevant traits, and potential genetic x diet interactions.
How neighborhood socioeconomic status, green space, and walkability are associated with risk for fracture among postmenopausal women
Authors: Wende Marilyn E , Lohman Matthew C , Friedman Daniela B , McLain Alexander C , Whitsel Eric A , Crandall Carolyn J , Cauley Jane A , Allison Matthew , Shadyab Aladdin H , Sealy-Jefferson Shawnita , Garcia Lorena , Cannell Michael B , Kaczynski Andrew T 
Published: February 2025

Abstract
Although most fractures, and about half of hip fractures, occur outdoors among older women, limited research has uncovered neighborhood predictors for fractures among older women. This study assessed the independent associations of neighborhood socioeconomic status, walkability, and green space with incident any and hip fracture among postmenopausal women. The Women’s Health Initiative recruited a national sample of postmenopausal women (50-79 years) across 40 U.S. clinical centers and conducted yearly assessments from 1993 to 2012 (n = 161 808). Women reporting a history of hip fracture or walking limitations were excluded from the analytic sample, yielding a final sample of 157 583 participants. Fracture events were self-reported and adjudicated annually. Walkability was calculated annually using measures of population density, land use mix, and presence/quantity of nearby high-traffic roadways. Neighborhood green space was calculated annually using measures of exposure to trees/vegetation. Neighborhood SES, walkability, and green space were categorized intro tertiles: high, intermediate, and low. The time-varying relationship between neighborhood environmental factors and age at first fracture (any; hip) was examined using extended Cox proportional hazards modeling with adjustment. Neighborhood socioeconomic status (intermediate vs low: hazard ratio = 1.03, 95% Confidence Interval (CI): 1.01-1.05; high vs low, hazard ratio = 1.01, 95% CI: 0.99-1.03) and green space (intermediate vs low, hazard ratio = 1.15, 95% CI: 1.12-1.18; high vs low hazard ratio = 1.18, 95% CI: 1.15-1.21) were associated with increased any incident fractures, while walkability had a mixed association (intermediate vs low hazard ratio = 1.06, 95% CI: 1.04-1.07; high vs low, hazard ratio = 0.97, 95% CI: 0.95-0.98). Neighborhood socioeconomic status, walkability, and green space did not have a relationship with hip fracture after adjustment for important covariates. Results indicate that macroscale neighborhood features did not protect against fractures. Additional research is needed to investigate more granual neighborhood features that might influence injury risk and support physical activity among postmenopausal women.
Explainable Artificial Intelligence twin for metaheuristic optimization: double-skin facade with energy storage in buildings
Authors: Tariq Rasikh , Recio-Garcia Juan A , Cetina-Quiñones Armando J , Orozco-del-Castillo Mauricio G , Bassam Ali 
Published: February 2025

Abstract
The double facade solar chimney along with energy storage components is a sustainable building technology that harnesses the power of the sun to regulate indoor temperatures. Extensive research has been conducted on the theoretical simulation of such systems. The novelty of this work is to explore the potential of explainable artificial intelligence in improving the design and optimization of the double-skin solar chimney. The need for this research is owing to the high computational limitations of the physical model of such systems, thus the application of explainable artificial intelligence based upon Artificial Neural Network can address this research gap. The paper solved a validated physical model and demonstrates the suitability of Artificial Neural Network twins as computational-efficient subrogates that can be later used by a multi-objective optimization function to find the optimal design values for the facades of double-skin buildings. The results of the comparison between the physical and the Artificial Neural Network model show the practical advantage of utilizing the digital twin model without compromising accuracy. The results have indicated that the Artificial Neural Network can achieve a high coefficient of determination ranging from 0.921 to 0.999 on different performance indicators which implies a high goodness of fit. Accordingly, the optimization study based upon a non-sorting genetic algorithm (NSGA-II) has indicated a high ventilation rate of 2.86 1/h and an efficiency of 37.21%. The insights of this work have reflected that exploring the societal implications of sustainable building technologies such as the double facade solar chimney through educational initiatives can cultivate a new generation of society who not only understand the technical aspects but also appreciate the broader social and environmental contexts of their work, eventually to have future buildings with integrated passive systems.
Non-target effects of insecticides and herbicides on earwigs
Authors: Hanel Aldo , Nottingham Louis B , Northfield Tobin D , Schmidt-Jeffris Rebecca 
Published: February 2025

Abstract
Conservation biological control in agriculture primarily relies on avoiding pesticides that may harm key natural enemies. In temperate tree fruit crops, the European earwig, Forficula auricularia (L.) has only recently become appreciated as an important predator of economic pests, particularly woolly aphids and pear psylla. Therefore, the non-target effects of orchard pesticides on earwigs are largely understudied. This is particularly true for herbicides, which earwigs are likely to be exposed to due to their foraging behavior moving between the canopy and the ground cover. We tested residues of formulated pesticides (8 insecticides and 7 herbicides) commonly used in tree fruit crops for lethal and sublethal (movement, predation rate) effects on adult female earwigs. Two herbicides, paraquat and glufosinate, and one insecticide, spinetoram, were acutely toxic to earwigs within 72 h. No tested pesticides altered earwigs’ movement or resting behavior compared to the control. The insecticides spinosad and cyantraniliprole and the herbicides 2,4-D, glufosinate, halosulfuron, rimsulfuron, and oxyfluorfen reduced earwig predation on green peach aphids. Therefore, these pesticides may reduce earwig predation on pests in orchards. Our results suggest that some pesticides are of greater risk, and thus, should be carefully considered or better timed when used in tree fruit orchards where earwigs are considered for conservation or augmentative biological control.
Environmental migration during the Great American Drought
Authors: Sichko Christopher 
Published: February 2025

Abstract
From 1930 to 1939, a devastating drought affected the USA. To study environmentally induced migration, I develop datasets of environmental conditions (drought, heat, and precipitation) and census data between 1930 and 1940. My analysis shows that people moved from drought during the early and late 1930s. County-level environmental-related depopulation resulted from increased out-migration and decreased in-migration. At the individual level, all occupational categories (farm labor, farmers, general labor, skilled labor, and white collar) moved from severe environmental conditions, though the response varied depending on rural status. Individuals near cities, but not in the cities themselves, were typically the most mobile in response to shocks. While severe conditions impacted migration across much of the Western USA, the Great Plains states witnessed the most dramatic population declines. My findings provide a detailed view of the environmental forces driving 1930s migration, demonstrate responsiveness across labor sectors, and highlight where people left due to environmental conditions.
Behavioral response of house flies (Diptera: Muscidae) to 3 bittering agents
Authors: Gunathunga Panchalie B , King Bethia H , Geden Christopher J 
Published: February 2025

Abstract
House flies, Musca domestica L., are pests at livestock facilities. House fly numbers are controlled mainly by manure management and chemical controls, like use of toxic baits. Some toxic baits contain denatonium benzoate as a bittering agent, to avoid poisoning of children. House fly behavioral response to denatonium benzoate was examined, using 2 different diluents, sucrose solution or orange juice. Response of flies to quinine and sucrose octaacetate, 2 other bittering agents, was also examined in sucrose. Sucrose is the sweetener in commercially available toxic house fly baits. The proboscis extension response of both male and female flies was significantly reduced by addition of 1,000 ppm of denatonium benzoate to sucrose. Response in males was also reduced at 100 ppm. Consumption of sucrose by both male and female flies was reduced by addition of 100, 500, and 1,000 ppm of denatonium benzoate, but consumption by males was also reduced at 10 ppm. Addition of sucrose octaacetate had no detectable effect on consumption of sucrose at 100, 500, or 1,000 ppm. In contrast, addition of quinine reduced consumption by both male and female flies in all tested concentrations. In orange juice, 10 ppm of denatonium benzoate is often avoided by children. With orange juice, fly proboscis extension response patterns were the same for both sexes, with a reduction at 1,000 ppm of denatonium benzoate. Orange juice consumption by flies was reduced significantly at 1,000 ppm of denatonium benzoate for females but not at any of the concentrations tested for males.
En bloc upper and lower lobe bisegmentectomy for non-small-cell lung cancer invading the fissure
Authors: Kosuge Atsushi , Yoshida Yukihiro , Yotsukura Masaya , Watanabe Shun-ichi 
Published: February 2025

Abstract

Background
The optimal surgical procedure for tumors extending deep into the lung parenchyma of the opposite lobe beyond the fissure remains controversial. The current study aimed to examine whether en bloc upper and lower lobe bisegmentectomy can be an option for such tumors.

Methods
This study included patients who underwent surgery for cN0 non-small-cell lung cancer invading the adjacent lobe beyond the fissure between the upper and lower lobes. The perioperative and long-term outcomes of the bisegmentectomy and extended lobectomy/pneumonectomy groups were compared.

Results
The bisegmentectomy group included five patients who underwent right S2 + S6 segmentectomy and four patients who underwent left S1 + 2 + S6 segmentectomy. The bisegmentectomy and extended lobectomy/pneumonectomy groups had similar perioperative outcomes. The median surgical duration, volume of blood loss and length of hospital stay of the bisegmentectomy group were 175 min, 79 mL and 5 days, respectively. In the bisegmentectomy group, one patient with a tumor without a ground-glass component on computed tomography scan had brain metastasis and died. The remaining eight patients with tumors with ground-glass components on computed tomography scan were alive without recurrence at a median follow-up of 7.2 years. In the extended lobectomy/pneumonectomy group, all patients experienced recurrence and died at a median follow-up of 3.9 years.

Conclusions
En bloc upper and lower lobe bisegmentectomy can be a safe and feasible option for tumors with a ground-glass component on computed tomography scan in patients with non-small-cell lung cancer invading the adjacent lobe beyond the fissure.
Decolonizing Environmental Education: Celebrating Epistemological Diversity Through Integrating Traditional Ecological Knowledge and Scientific Knowledge in Oman
Authors: Alhinai Maryam 
Published: February 2025

Abstract
My goal in this project is to understand how traditional ecological knowledge (TEK) manifests—or fails to manifest—in environmental education policy issued by the Ministry of Education in Oman. I also seek to explore whether there are cultural pressures in Omani society to overlook traditional ecological knowledge in environmental education policy. Specifically, my aim is to understand how forces of globalization interact with traditional ecological knowledge in Oman and whether these forces are behind the tendency to unknowingly ignore traditional ecological knowledge when designing the environmental education policy. Drawing on critical decolonial studies, post-Heideggerian philosophy and environmental education pedagogy, this paper investigates the Policy of Environmental Education for Sustainable Development in Oman, which is a government document issued by the ministry of education in 2012 as a blueprint for designing environmental education curricula in Oman. My analysis of the Policy reveals that there is both a tension with and a potential for a pluriversal approach—one that embraces the coexistence and mutual enrichment of scientific knowledge and traditional ecological knowledge in environmental education. While the focus on scientism has historically marginalized TEK, this paper argues for a pluriversal framework that values multiple ways of knowing. By fostering a dialogue between these knowledge systems, environmental education can become more inclusive, holistic, and ecoculturally sustainable. I argue for honoring indigenous worldviews and celebrating the manifestations of our ecological heritage by integrating traditional ecological knowledge into a land-based pedagogy that works alongside scientific perspectives, promoting a richer understanding of the environment.