bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior Cruciate Ligament Reconstruction: Common Intraoperative Mistakes and Techniques for Error Recovery
Authors: Wang Kevin C. , Keeley Timothy , Lansdown Drew A. 
Published: February 2025

Abstract

Purpose of Review
Anterior cruciate ligament (ACL) reconstruction is a commonly performed procedure among general orthopedists, and is a logged procedure required for graduation from accredited orthopaedic residency programs.

Recent Findings
ACL reconstruction surgery has a number of critical steps, and intraoperative errors can significantly impact the success rate and morbidity of this operation. Technical errors are frequently cited as some of the most common reasons for ACL reconstruction failure. This narrative review provides low-volume surgeons and trainees with an overview of the common errors that can be made during the critical steps of an ACL reconstruction procedure.

Summary
We suggest technical points for avoiding commonly-encountered errors and provide a description of evidence-supported error recovery techniques to address these errors if they occur intraoperatively. These key steps include femoral tunnel creation, tibial tunnel creation, graft harvest and preparation, and graft fixation within the tunnels. We discuss a number of primary and backup fixation strategies as well as all commonly used autografts (bone-patellar tendon-bone, hamstring, and quadriceps tendon). Additionally, we provide a brief overview on address intra-operative graft contamination citing currently available evidence.
CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro
Authors: Martinez-Zalbidea Iker , Wagner Gabbie , Bergendahl Nea , Mesfin Addisu , Puvanesarajah Varun , Hitzl Wolfgang , Schulze Stefan , Wuertz-Kozak Karin 
Published: February 2025

Abstract

Purpose
The purpose of this study was to boost the therapeutic effect of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) by overexpressing the gene TSG-6 through CRISPR activation, and assess the biological activity of EVs from these modified MSCs in vitro on human intervertebral disc (IVD) cells.

Methods
An immortalized human MSC line was transduced with a CRISPR activation lentivirus system targeting TSG-6. MSC-EVs were harvested by ultracentrifugation and particle number/size distribution was determined by nanoparticle tracking analysis. The efficiency of transduction activation was assessed by analyzing gene and protein expression. EV proteomic contents were analyzed by mass spectrometry. Human IVD cells from patients undergoing spinal surgery were isolated, expanded, exposed to IL-1β pre-stimulation and co-treated with MSC-EVs.

Results
MSC-EVs presented size distribution, morphology, and molecular markers consistent with common EV characteristics. The expression level of TSG-6 was significantly higher (> 800 fold) in transduced MSCs relative to controls. Protein analysis of MSCs and EVs showed higher protein expression of TSG-6 in CRISPR activated samples than controls. Proteomics of EVs identified 35 proteins (including TSG-6) that were differentially expressed in TSG-6 activated EVs vs control EVs. EV co-Treatment of IL-1β pre-Stimulated IVD cells resulted in a significant downregulation of IL-8 and COX-2.

Conclusions
We successfully generated an MSC line overexpressing TSG-6. Furthermore, we show that EVs isolated from these modified MSCs have the potential to attenuate the pro-inflammatory gene expression in IVD cells. This genomic engineering approach hence holds promise for boosting the therapeutic effects of EVs.
Profan, aber immer aktuell: Behandlung von Warzen
Authors: Kopera Daisy , Schmidhumer Lisa 
Published: February 2025

Zusammenfassung
Die klinische Studie vergleicht zwei topische Behandlungsmethoden – 35 % Trichloressigsäure (Gruppe A) und Kryotherapie mit Norfluran (Gruppe B) – bei Warzen im Kindes- und Jugendalter. Es wurden insgesamt 41 Warzen bei neun Studienteilnehmer:innen behandelt. Die statistische Auswertung ergab eine bessere Wirksamkeit der Kryotherapie mit Norfluran (Hydrozid®-Spray) im Vergleich zu TCA 35 %, allerdings mit einem größeren Schmerzprofil (4/10) als TCA (0/10).
Exploring the scope of generative AI in literature review development
Authors: Schryen Guido , Marrone Mauricio , Yang Jiaqi 
Published: February 2025

Abstract
Artificial intelligence (AI) has the potential to transform the way research is conducted, particularly through generative AI (GenAI) tools which can enhance written communication and foster innovation via knowledge development. This study focuses on the latter, examining the role of GenAI in specific knowledge development activities within literature reviews. Through an epistemological lens, we distinguish six key knowledge development activities: research synthesis, evidence aggregation, critique, theory building, research gap identification, and research agenda development. Our analysis demonstrates both the capabilities and limitations of GenAI in supporting these activities, highlighting how GenAI can assist in synthesizing previous work, discovering and integrating concepts, and advancing various knowledge domains. We emphasize a human-centered, synergistic approach where GenAI complements researchers’ efforts, rather than replacing them. Additionally, our activity-centric analysis provides insights into how different types of literature reviews can effectively benefit from GenAI support, thereby contributing to a broader understanding of AI integration in information systems research.
A re-description of the teleosauroid Macrospondylus bollensis (Jaeger, 1828) from the Posidonienschiefer Formation of Germany
Authors: Johnson Michela M. , Sachs Sven , Young Mark T. , Abel Pascal 
Published: February 2025

Abstract
Teleosauroid crocodylomorphs were a successful, diverse and abundant clade that expanded near-globally during the Jurassic Period. Teleosauroids are commonly found in Toarcian strata (Early Jurassic) within Europe, with multiple unique specimens pertaining to four taxa having been discovered in the Posidonienschiefer Formation (= Posidonia Shale) in southwestern Germany. The majority of these specimens have been referred to Macrospondylus bollensis (Jaeger, 1828), a basal machimosaurid species previously assigned to the genus Steneosaurus. Macrospondylus bollensis, as a species, is known to have a long and impressive history; unfortunately, the holotype of Ma. bollensis is poorly understood, rarely referenced in the current literature and is often incorrectly thought to be a teleosauroid specimen from Whitby. The actual holotype (housed at the Museum für Mineralogie und Geologie in Dresden), while badly burned, offers valuable information on basal teleosauroid postcranial material. We provide a detailed re-description of Macrospondylus bollensis, recognize it as a valid taxon and compare it with other Toarcian and machimosaurid teleosauroids. In addition, we evaluate the ecology and biogeographical distribution of Macrospondylus.
Il GHRH - Un neuropeptide non solo ipofisiotropo
Authors: Gesmundo Iacopo , Granata Riccarda 
Published: February 2025

Sommario
L’ormone ipotalamico growth hormone-releasing hormone (GHRH), oltre a promuovere il rilascio di GH da parte dell’adenoipofisi, esercita numerosi effetti a livello periferico. Diversi studi hanno infatti dimostrato importanti azioni extra-ipofisarie del GHRH e dei suoi analoghi agonisti sintetici, suggerendo il loro possibile sviluppo clinico nelle patologie cardiovascolari, neurodegenerative, nel diabete e nelle malattie metaboliche.
An Epidemiological Investigation of Inter-Developmental, Biopsychosocial Impairment among Children and Adolescents in Foster Care
Authors: Tarren-Sweeney Michael , Nunn Kenneth Patrick 
Published: February 2025

Abstract
Early exposure to chronic maltreatment and other biopsychosocial adversities accounts for high prevalence of developmental impairments among children residing in foster care and other types of statutory out-of-home care (OOHC), including: complex, trait-like mental health difficulties; intellectual disability (ID); and speech and language difficulties (SLD). However, little is known about the characteristics and prevalence of co-occurring mental health difficulties and developmental disabilities among this population – which we refer to as inter-developmental impairment. The present article reports findings from epidemiological surveys of pre-adolescent school-aged children (N = 347) and adolescents (N = 230) residing in foster and kinship care in New South Wales, Australia. Mental health was measured from caregiver-reported Child Behavior Checklist and Assessment Checklist for Children / Assessment Checklist for Adolescents scores; and ID and SLD were reported in a caregiver questionnaire. The proportions of children and adolescents with caregiver-reported ID were 22.5% (78/347) and 30.0% (69/230) respectively, while the proportions with SLD were 21.6% (75/347) and 15.7% (36/230) respectively. While mental health case rates were high among the aggregate child (67%) and adolescent (60%) samples, those with ID and/or SLD were considerably more likely to have clinical-level mental health difficulties compared to those without ID or SLD, with odds ratios ranging from 1.9 to 6.5. The prevalence of inter-developmental impairment (defined as having ID and/or SLD, as well as mental health caseness) among the child and adolescent samples was 23.9% and 28.7% respectively. Children and adolescents with inter-developmental impairment on average had with more complex symptomatology than did mental health cases without reported developmental difficulties. The article discusses mechanisms accounting for inter-developmental impairment among formerly maltreated children residing in foster care, and implications for clinical services.
Human Rights in Sociopsychological Perspective
Authors: Ardila‑Sánchez José G. , López‑López Wilson 
Published: February 2025

Abstract
From the standpoint of sociopsychology, we attempt to isolate those aspects of human rights that are distinctly sociopsychological in nature, to later identify them as interindividual segments of social system dynamics. In social perspective, human rights may be viewed as social events and, in a sociopsychological perspective, all social events are conceptualized as social formations of interacting contingencies. Such social formations are constituted of interindividual relations set in a complex of institutional practices. The interindividual relation is conceptualized as a set of contingencies directly affecting individual behavior and has three dimensions: exchange, power, and sanction. Institutions are conceptualized as sociohistorical circumstances having their origins as informal or formal practices. Human rights are addressed in terms of interindividual dimensions and institutional practices constituting specific social formations.
Functionalized Separators Boosting Electrochemical Performances for Lithium Batteries
Authors: Fan Zixin , Chen Xiaoyu , Shi Jingjing , Nie Hui , Zhang Xiaoming , Zhou Xingping , Xie Xiaolin , Xue Zhigang 
Published: February 2025

Abstract
The growing demands for energy storage systems, electric vehicles, and portable electronics have significantly pushed forward the need for safe and reliable lithium batteries. It is essential to design functional separators with improved mechanical and electrochemical characteristics. This review covers the improved mechanical and electrochemical performances as well as the advancements made in the design of separators utilizing a variety of techniques. In terms of electrolyte wettability and adhesion of the coating materials, we provide an overview of the current status of research on coated separators, in situ modified separators, and grafting modified separators, and elaborate additional performance parameters of interest. The characteristics of inorganics coated separators, organic framework coated separators and inorganic–organic coated separators from different fabrication methods are compared. Future directions regarding new modified materials, manufacturing process, quantitative analysis of adhesion and so on are proposed toward next-generation advanced lithium batteries.

Graphical abstract
Improved Conceptual Design of eVTOL Aircraft: Considering Rotor–Rotor Interactional Effects
Authors: Kim Hojin , Lee Jinwhuy , Lee Donguk , Yee Kwanjung 
Published: February 2025

Abstract
Electric vertical takeoff and landing (eVTOL) aircraft equipped with a distributed electric propulsion (DEP) system have rotors positioned close to one another, leading to unsteady rotor–rotor interactions. These interactions are known to increase rotor aeroacoustic noise due to aerodynamic load fluctuations. Therefore, capturing the noise increase caused by rotor interactions is critical during the conceptual design phase of eVTOL aircraft. Low-fidelity rotor analysis models, such as blade element momentum theory (BEMT), which are commonly used in conventional conceptual design frameworks for their efficiency, fail to account for rotor–rotor interaction effects as they assume each rotor operates in isolation. In this study, a rotor aeroacoustic solver is integrated into the conceptual design framework, RISPECT+. Additionally, a new aerodynamic coupling module between two distinct aerodynamic solvers is developed to capture the noise increase from rotor–rotor interactions. In this module, rotor aerodynamic analysis results from the lower-fidelity model are corrected based on differences with the higher-fidelity model, enabling the capture of aerodynamic force unsteadiness and the resulting noise increase. Finally, this new framework is used to conduct sensitivity analysis and multi-objective design optimization, taking into account both gross weight and noise impact.
Enhancing Dynamic Control and Stability Assessment of Cessna 172 Aircraft with a PID Controller for New Pilot Trainees
Authors: Dagal Idriss , Erol Bilal , Harrison Ambe , Mbasso Wulfran Fendzi , Ibrahim AL-Wesabi 
Published: February 2025

Abstract
This research proposes a novel approach to enhance the dynamic control and stability assessment of the Cessna 172 aircraft for new pilot trainees by incorporating a proportional–integral–derivative (PID) controller. The PID controller is designed to improve the aircraft’s responsiveness to control inputs, reduce overshoot and settling time, and enhance overall stability. The study involves developing a mathematical model of the Cessna 172’s longitudinal dynamics, designing a PID controller, and conducting simulations to evaluate the performance of the PID-controlled aircraft. The evaluation focuses on key metrics such as stability, responsiveness, overshoot, and settling time. The results of the study demonstrate that the PID controller effectively enhances the dynamic control and stability of the Cessna 172, providing new pilot trainees with a safer and more efficient learning experience. The PID controller’s ability to mitigate the effects of pilot errors and disturbances contributes to improved flight performance and reduced risk of accidents. Future research directions include exploring the use of adaptive PID controllers, integrating PID controllers with other advanced flight control systems, and conducting flight tests to validate the performance of the PID-controlled Cessna 172 in real-world conditions.
Influence of hybrid air-cooled based strategy on thermal management system performance
Authors: Oyewola Olanrewaju M. , Idowu Emmanuel T. , Drabo Mebougna L. 
Published: February 2025

Abstract
Existing cooling strategies have shown reasonable performance enhancement in the design of air-cooled battery thermal management systems (BTMSs). However, some of these strategies are accompanied with drawbacks such as increase in pressure drop, poor flow uniformity and poor thermal homogeneity. This study adopts hybrid cooling strategy (HCS), through combination of existing air-cooling strategies to investigate the performance of Z–Type BTMSs. Computational Fluid Dynamics (CFD) method was used to evaluate the performance of the HCSs. The method was validated by comparing Z–Type BTMS numerical simulation results with experimental result from literature. Findings from the study revealed that each strategy provides distinct maximum temperature (

$${T}_{max}$$

T

max

), maximum temperature difference (

$${\Delta T}_{max}$$

Δ
T

max

), pressure drop (

$$\Delta P$$

Δ
P

) and pumping power (

$${P}_{p}$$

P
p

) performances for the same operational parameters. For designs with single enhancement, step-like design produced best thermal performance with

$${T}_{max}=331.16 K$$

T

max

=
331.16
K

and

$${P}_{p}=0.0841 W$$

P
p

=
0.0841
W

. A design with combination of two strategies, also produced reduction in

$${T}_{max}$$

T

max

and

$$\Delta {T}_{max}$$

Δ

T

max

by 4.25 K and 8.66 K, respectively, with 2.34 Pa increase in

$$\Delta P$$

Δ
P

, when compared with the Z–Type BTMS. Another design with single strategy produced reduction in

$${T}_{max}$$

T

max

and

$$\Delta {T}_{max}$$

Δ

T

max

by 4.42 K and 8.01 K, respectively with 3.52 Pa increase in

$$\Delta P$$

Δ
P

when compared with the same Z–Type BTMS. This performance shows 3.85% increase in

$${T}_{max}$$

T

max

and with 33.5% reduction in

$$\Delta P$$

Δ
P

. Several other designs also exhibited similar performance trend. Hence, this study concludes that adopting hybridization of air-cooled technique in BTMS is a promising technique with wide potential unexplored.
The instrumental value of advance directives: lesson learned from the COVID-19 pandemic for policymaking
Authors: Stock Elisabeth , Nickel Christian H. , Elger Bernice S. , Martani Andrea 
Published: February 2025

Abstract
Open conversations between patients and healthcare professionals (HCP) are required to evaluate which treatments are reasonable for the individual case, especially towards the end of life. Advance Care Planning (ACP), which often results in drafting an Advance Directive (AD), is a useful tool to help with decisions in these circumstances, but the rate of AD completion remains low. During the COVID-19 pandemic, ACP and AD gained popularity due to the alleged advantage that they could facilitate resource allocation, to the benefit of public health. In this article, which presents a theoretical reflection grounded in scientific evidence, we underline an even stronger ethical argument to support the implementation of AD in end-of-life care (eol-C) i.e. the instrumental value at the individual level. We show, with particular reference to lessons learned from the COVID-19 pandemic, that AD are instrumentally valuable in that they: (1) allow to thematise death; (2) ensure that overtreatment is avoided; (3) enable to better respect the wish of people to die at their preferred place; (4) help revive the “lost skill” of prognostication. We thus conclude that these arguments speak for promoting the territorially uniform implementation and accessibility of high-quality AD in care.
Surgical Factors Influencing Quality of Life After Reduction Mammaplasty in Patients with Breast Hypertrophy
Authors: Chotárová Martina , Mihalečko Ján , Mayer Alexander , Boháč Martin 
Published: February 2025

Abstract

Background
Breast hypertrophy causes a variety of physical and psychological problems for patients, both of which lead to decreased quality of life. This research aimed to compare patients’ quality of life before and after elective breast reduction surgery and to evaluate factors contributing to improved quality of life after surgery.

Methods
Fifty-one women aged 18–65 years were enrolled. The data about the quality of life were obtained retrospectively using a standardized Breast-Q questionnaire© and evaluated by the software evaluation tool QScore©.

Results
The mean age of participants was 42.33 ± 10.30 years. The overall quality of life improved significantly by 60%. On average, the respondents had 1,119.2 g of breast tissue removed per breast. Before the surgery, the average body mass index was 29.88, while after surgery it was 27.52. The average breast size was 6.41 before surgery and 3.3 (i.e., cup sizes C—D) after surgery. The average time of questionnaire return was 3.9 ± 2.99 years after surgery. The average time spent in the hospital was 6.02 ± 1.44 days. The complication rate was 23%. None of these factors influenced the patients' satisfaction with the outcome. However, the surgical technique chosen seemed to play a significant role in the satisfaction of patients with the reduction.

Conclusions
In our study, reduction mammaplasty improved the well-being of the patients in all aspects of the Breast-Q questionnaire. Of the observed factors, only the surgical technique appeared to affect satisfaction with long-term outcomes significantly.

Trial registration
Clinicaltrials.gov No.: NCT02769559.
Beyond the Four Seas: Chi Jiu Zhi Ji Tang Zhi Wu 赤鳩之集湯之屋 And The Roles of Ministers in Early China
Authors: Yang Huiyao 
Published: February 2025

Abstract
Chi jiu zhi ji Tang zhi wu (赤鳩之集湯之屋, “[When] Red Doves Gathered on Tang’s house”) is an excavated Chu manuscript that belongs to the Tsinghua University bamboo slips collection. The manuscript concerns several important early Chinese figures such as Tang and Yi Yin, while also featuring rich supernatural elements. Many studies have focused on “shamanism elements” depicted in the tale or defined the genre of the text as xiaoshuo. This article offers a reexamination of Chi jiu and the above assumptions by contextualizing the text within its original three-text manuscript. The article reveals how early compilers constructed a chronological sequence to frame an overarching narrative in a heterogeneous compilation, and further generates a unique narrative regarding the extraordinary status of Yi Yin the founding minister. In its conclusion, the paper draws attention to potential alternative narratives about the minister-ruler relationship in early China, and also places Chi jiu in the context of early compilation practices. Additionally, it considers possible parallels between the Chi jiu story and two of the Grimms’ Tales, viewing Chi jiu within folklore studies.
El Niño-driven flooding and mental health symptomology among adolescents and young adults in Peru
Authors: Cerna-Turoff Ilan , Kang Hyunseung , Keyes Katherine M. 
Published: February 2025

Abstract
Intensifying storms and inter-annual El Niño events may increase psychological stress and worsen mental health. This study examines the relationship between flood exposure and long-term mental health symptoms among adolescents and young people in Peru, the world’s most affected country by El Niño. We analyzed community and self-reported survey data from the Young Lives Study to contrast mental health in 2016 among youth who lived in communities that experienced or did not experience flooding between 2013 and 2016. We pre-processed data on 1344 individuals in 93 communities, using optimal full matching on Mahalanobis distance with a propensity score caliper, and estimated relative risks to mental health scores in the general population of young people and among gender-stratified groups via quasi-Poisson regression. Exposure to floods did not yield conclusive differences in mental health scores in this sample. Further evidence is needed on mental health patterns over time, the influence of exposure severity, and the impact of disaster relief on symptomology in mounting an effective global health response.