bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value
Authors: Cioni Paul , Chretien Pascale , Goulvestre Claire , Ballot Eric , Khelifi-Touhami Dounia , Mariette Xavier , Nocturne Gaëtane 
Published: February 2025

ObjectiveAnti-SS-B antibodies are often associated with anti-SS-A in Sjögren’s disease. Compared to anti-SS-A antibody positivity, the significance of the immunological profile anti-SS-B positive/anti-SS-A negative remains controversial. We aimed to evaluate the prevalence and diagnostic significance of isolated anti-SS-B antibodies.MethodsWe conducted a retrospective study across three hospitals of the Assistance Publique—Hôpitaux de Paris. Patients with anti-SS-B positivity were identified using ELISA, addressable laser beam immunoassay (ALBIA) and immunodot assays. They were retained if anti-SS-B was positive in two techniques and anti-SS-A was absent. Clinical, biological and immunological data were extracted and presented in a descriptive analysis.ResultsA total of 80 540 requests for anti-SS-B antibody testing were carried out over a period of 7.9 years. Anti-SS-B positivity was found in 1693 patients. Among them, 335 (19.8%) patients had isolated anti-SS-B in ELISA/ALBIA. Immunodot was performed in 186 of them and confirmed anti-SS-B positivity in 61 patients (3.6% of anti-SS-B positivity). 24 patients (39.3%) presented with a history of various autoimmune or autoinflammatory diseases and only 6 were diagnosed with a new connective tissue disease. After a median follow-up of 26 months, only two new diagnoses were made.ConclusionAnti-SS-B without anti-SS-A is exceedingly rare when accurately identified by a rigorous immunological approach. The initial anti-SS-B positivity does not correlate with a specific condition, both at the time of initial identification and after a 26-month follow-up period. This supports the fact that isolated anti-SS-B has no diagnostic or prognostic value.
Removing or returning freedom? Views on a nicotine-free generation policy held by young people from aotearoa who use electronic nicotine delivery systems (ENDS)
Authors: Hoek Janet , Hosking Renee , Graham-DeMello Anna , Sanders Carissa , Teddy Lani , Ball Jude , van der Eijk Yvette , Gallopel-Morvan Karine 
Published: February 2025

IntroductionInternational interest in a smokefree generation policy has grown as more local authorities and governments move to introduce this policy. Young people strongly support this measure, but we know less about how they view a nicotine-free generation policy that includes electronic nicotine delivery systems (ENDS). We addressed this gap by probing adolescents’ views on a birth-year policy that included all nicotine products.MethodsWe undertook in-depth interviews with 20 adolescents aged 16–18 who self-assessed as moderately or severely addicted to vaping and lived in Aotearoa New Zealand. In semistructured interviews, we explored participants’ views on a nicotine-free generation, its rationale, implementation and likely impact. We interpreted the data using a reflexive thematic analysis approach.ResultsMost participants supported a nicotine-free generation, rejected arguments that ENDS use was a ‘choice’, and called for government leadership to protect them and future generations; a small minority saw the measure as unwarranted interference. Several participants thought compliance would be low, given their experiences of lax age verification practices and the widespread social supply of ENDS, but suggested measures to improve compliance.ConclusionsAlthough participants thought a nicotine-free generation could impose personal hardship, most privileged the freedom they thought it could bring over the illusory ‘choice’ they currently had. Policy-makers should consider looking beyond a smokefree generation to a nicotine-free generation; alongside this measure, they should implement strong enforcement and provide comprehensive support so young people addicted to nicotine can be empowered to stop using ENDS.
Exploration of Jupiter’s Galilean satellites and their complex interactions with the Jovian magnetosphere: Hungary’s participation in ESA’s Jupiter Icy Moons Explorer mission
Authors: Bebesi Zsofia 
Published: February 2025

Abstract
Jupiter's magnetosphere is one of the largest natural particle accelerators in our Solar System. Its dynamic processes are governed by the fast rotation of the planet, creating complex current systems and particle transport mechanisms. The Galilean satellites play important roles as plasma sources, influencing the dynamics and distribution of charged particles in the Jovian magnetosphere. Building on the knowledge gained from previous flybys and the Galileo orbiter, the recently launched Jupiter Icy Moons Explorer (JUICE) spacecraft will study the interaction between the Galilean satellites and the rapidly rotating inner magnetospheric plasma environment of Jupiter. The mission will conduct several close flybys with Europa and Callisto to further investigate the possibility of the existence of their subsurface oceanic layers. Additionally, JUICE aims to study in unprecedented detail the unique interaction between Ganymede (the only satellite in our Solar System with an intrinsic magnetic field of its own) and the Jovian magnetosphere. Researchers and engineers from the HUN-REN Wigner Research Centre for Physics, the HUN-REN Centre for Energy Research, and SGF Ltd. have participated in the development of the Particle Environment Package (PEP) instrument onboard JUICE.
Validation of a Demography-Based Adaptive QT Correction Formula Using Pediatric and Adult Datasets Acquired From Humans and Guinea Pigs
Authors: Haq Kazi T. , McLean Kate M. , Anderson-Barker Grace C. , Berul Charles I. , Shattock Michael J. , Posnack Nikki Gillum 
Published: February 2025

BACKGROUND:
QT correction (QTc) formulae are widely used in clinical and research settings but often underperform, possibly due to demographic influences on the QT–heart rate (HR) relationship. To address this limitation, we developed an adaptive QTc (QTcAd) formula, which adjusts for demographic factors like age, and compared its efficacy to other standard formulae.

METHODS:

The QTcAd formula was tested across diverse age groups with different HR in both humans and guinea pigs. Using retrospective ECG data from 1819 pediatric patients at Children’s National Hospital and 2400 subjects from the Pediatric Heart Network database, alongside in vivo (N=55) and ex vivo (N=66) guinea pig ECG recordings, we evaluated the formula’s effectiveness. Linear regression fit parameters of QTc-HR (slope and
R
²) were utilized for performance assessment. To evaluate the accuracy of the predicted QTc, we acquired epicardial electrical and optical voltage data from Langendorff-perfused guinea pig hearts.

RESULTS:

In both human subjects and guinea pigs, the QTcAd formula (QTcAd=QT+(|
m
|×(HR−HR
mean
)) consistently outperformed other formulae across all age groups. For instance, in a 20-year-old human group, the QTcAd formula successfully nullified the inverse QT-HR relationship (
R
²=5.1×10
−10
, slope=−3.5×10
−5
), whereas the Bazett formula failed to achieve comparable effectiveness (
R
²=0.21, slope=0.91). Moreover, the QTcAd formula exhibited better accuracy than the age-specific Benatar QTc formula, which overcorrected QTc (1-week human QT: 263.8±14.8 ms, QTcAd: 263.8±7.3 ms,
P
=0.62; Benatar QTc: 422.5±7.3 ms,
P
<0.0001). The optically measured pseudo-QT interval (143±22.5 ms, n=44) was better approximated by QTcAd (180.6±17.0 ms) compared with all other formulae. Furthermore, we demonstrated that the QTcAd formula was not inferior to individual-specific QTc formulae.

CONCLUSIONS:
The demography-based QTcAd formula showed superior performance across human and guinea pig age groups, which may enhance the efficacy of rate-corrected K.M.M. for cardiovascular disease diagnosis, risk stratification, and drug safety testing in children and adults.
An open access resource for marmoset neuroscientific apparatus
Authors: Zimmermann Rollin Isabela , Papoti Daniel , Bishop Mitchell , Szczupak Diego , Corigliano Michael R. , Hitchens T. Kevin , Zhang Bei , Pell Sarah K. A. , Guretse Simeon S. , Dureux Audrey , Murai Takeshi , Sukoff Rizzo Stacey J. , Klassen L. Martyn , Zeman Peter , Gilbert Kyle M. , Menon Ravi S. , Lin Meng-Kuan , Everling Stefan , Silva Afonso C. , Schaeffer David J. 
Published: February 2025

Abstract
The use of the common marmoset (Callithrix jacchus) for neuroscientific inquiry has grown precipitously over the past two decades. Despite windfalls of grant support from funding initiatives in North America, Europe, and Asia to model human brain diseases in the marmoset, marmoset-specific apparatus are of sparse availability from commercial vendors and thus are often developed and reside within individual laboratories. Through our collective research efforts, we have designed and vetted myriad designs for awake or anesthetized magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), as well as focused ultrasound (FUS), electrophysiology, optical imaging, surgery, and behavior in marmosets across the age-span. This resource makes these designs openly available, reducing the burden of de novo development across the marmoset field. The computer-aided-design (CAD) files are publicly available through the Marmoset Brain Connectome (MBC) resource (https://www.marmosetbrainconnectome.org/apparatus/) and include dozens of downloadable CAD assemblies, software and online calculators for marmoset neuroscience. In addition, we make available a variety of vetted touchscreen and task-based fMRI code and stimuli. Here, we highlight the online interface and the development and validation of a few yet unpublished resources: software to automatically extract the head morphology of a marmoset from a CT and produce a 3D printable helmet for awake neuroimaging, and the design and validation of 8-channel and 14-channel receive arrays for imaging deep structures during anatomical and functional MRI.
Morphological and molecular characterisation of Aculonchus fumanensis sp. nov. (Nematoda, Dorylaimida, Leptonchidae) from Iran, with a revised taxonomy of the genus
Authors: Esmaeili Maedeh , Amiri Bonab Mohammad , Atighi Mohammad Reza , Bazeghi Fatemeh , Pedram Majid , Peña-Santiago Reyes 
Published: February 2025

Summary
A new species of the rare leptonchid genus Aculonchus collected from two natural habitats of northern Iran, is characterised, including morphological description, morphometrics and molecular (18S, 28S rDNA) study. Aculonchus fumanensis sp. nov. is distinguished by its 0.64-0.92 mm long body, cuticle tylencholaimid and with abundant radial refractive elements, lip region cap-like, 9.5-10 μm wide and offset by deep constriction, stylet 26-32 μm long, odontophore bearing distinct basal flanges, neck 145-177 μm long, pharyngeal basal bulb up to one-sixth of the total neck length and bearing a valvular chamber inside, female genital system di-ovarian with simple uterus and transverse vulva (V = 51-66), female tail conical and almost straight (25-34 μm, c = 20-27, c′ = 1.5-2.1), and male unknown. The taxonomy of Aculonchus is revised, with an updated diagnosis, list of species, key to their identification, and a compendium of their main morphometrics. Besides, the evolutionary relationships of Aculonchus are briefly discussed.
The role of exercise intensity and duration on cardiac angiogenesis
Authors: Fitrianti H.P. , Ramadhan H.A. , Sylviana N. , Goenawan H. 
Published: February 2025

Abstract
Numerous studies showed the exercise intensity and exercise duration involved in the pathways of angiogenesis biomarkers expression. The aim of this systematic review was to analyse the effects of different exercise intensities and exercise duration in cardiac angiogenesis regulation between healthy animal studies and human studies. The research databases used in this systematic review, including MEDLINE and Cochrane Library, within the last 6 years from 2018 to 2023 and published in English. Before the study selection, the study duplication was detected by Zotero Reference Manager® and then removed. The related studies examined and selected with rayyan.ai® website using a ‘blind-on’ mode to ensure eligibility. The eligible studies were assessed by the SYRCLE’s risk of bias tool and Risk of Bias Tool 2.0. A total of 16 studies were included, consisting of 5 animal studies or in vivo or experimental studies and 11 human studies or clinical trials. The studies then grouped in 3 durations of exercise, that was short-term, long-term term-intermittent, and long-term-continuous exercise. The most significant duration and intensity were found in long-term-continuous exercise and moderate to vigorous intensity exercise. Further research needs to explain the other factors of exercise that influence cardiac angiogenesis, such as the frequency and the type of exercise both in humans and animals to determine the most effective exercise program for a healthy population, as a potential prevention from the cardiovascular disease.
Modal Meinongianism Doesn’t Exist
Authors: Connolly Niall 
Published: February 2025

Abstract
Meinongianism takes non-existent objects to actually possess the qualities they are characterised as possessing. But many of these qualities are existence entailing. Priest and Berto’s modal Meinongianism tries to circumvent this problem by taking Pegasus to possess the property of being winged in some nonactual world. I argue that modal Meingongianism’s individuation criterion for fictional and imaginary entities doesn’t allow us to rule out that Emma Woodhouse and Batman are identical. I further argue that depending on the status of the ‘other worlds’ it posits, modal Meinongianism either trivialises Meinongianism’s ‘characterisation principle’ or replaces it with something no less objectionable. Priest and Berto’s view, I conclude, if it is tenable, is not a form of Meinongianism; but arguably it is something better: a structuralist account of non-existent objects.
On the Existence of Nonexistence Commitments
Authors: Rouillé Louis 
Published: February 2025

Abstract
In this article, I introduce a new kind of ontological commitment, according to which one is committed to the nonexistence of some entity. I start with an analysis of ontological commitment which gives prominence to Putnam’s notion of “intellectual honesty” and proceed to argue that whatever the correct view of ontological commitment is, there is a variety of understudied ontological commitment, viz. nonexistence commitments. Based on such commitments, one can make what I call “counter-indispensability arguments”, which are formally similar to indispensability arguments, though the conclusion is antirealist as opposed to realist. I argue that all the reasons we have to accept and use indispensability arguments in ontology carry over to counter-indispensability arguments. Finally, I apply this new tool to two ontological debates. I illustrate how it helps distinguishing between soft and strong versions of antirealism about philosophically controversial entities.
The Competitive Edge: Improving American Board of Surgery In-Training Examination Scores Through a Team-Based Competition
Authors: Masters Sean E. , Howard Kathryn K. , Foote Darci C. , Halka Joshua , Studzinski Diane , Callahan Rose , Ivascu Felicia A. , Akay Begum 
Published: February 2025

Background The American Board of Surgery (ABS) In-Training Examination (ABSITE) scores are predictive of passing the ABS qualifying exam and have become a marker of residency education success. A competitive team-based approach to encourage self-studying and didactic participation is a novel method of ABSITE preparation. We aimed to determine if this method significantly improves residents’ percentile performances on the ABSITE. Methods Retrospective review of ABSITE percentile scores were compared before and after implementation of a purchased online question bank (TrueLearn LLC, Mooresville, NC), a team-based competition, and a virtual format of the team-based competition. Results The median ABSITE percentile at the program level increased from 40.0 (IQR 21.0-67.0) in 2011 to 77.0 by 2022 (IQR 60.0-91.0) ( P < 0.0001). After implementation of the team-based competition, ABSITE median percentile rose significantly from 67.0 (IQR 31.5-85.5) to 84.5 (IQR 60.8-91.0) ( P = 0.026). This did not change significantly after a transition to a virtual format of the team-based competition in 2021 ( P = 0.146) and 2022 ( P = 0.335). There was no significant relationship between the number of TrueLearn questions taken and ABSITE scores specifically before and after implementation of the team-based competition (AUC = 0.0002, Spearman’s r (67) 0.064, P = 0.605). Furthermore, the team-based competition was well received by residents and was believed to be beneficial to their studying. Discussion The team-based competition is easy to implement and improves ABSITE performance through means other than encouraging residents to take more practice questions. The team-based competition is well-received by residents and may prove beneficial to board examination preparation and pass rates.
CT-based radiomics: A potential indicator of KRAS mutation in pulmonary adenocarcinoma
Authors: Mahmoud Menna Allah , Wu Sijun , Su Ruihua , Liufu Yuling , Wen Yanhua , Pan Xiaohuan , Guan Yubao 
Published: February 2025

Purpose: This study aimed to validate a CT-based radiomics signature for predicting Kirsten rat sarcoma (KRAS) mutation status in lung adenocarcinoma (LADC). Materials and methods: A total of 815 LADC patients were included. Radiomics features were extracted from non-contrast-enhanced CT (NECT) and contrast-enhanced CT (CECT) images using Pyradiomics. CT-based radiomics were combined with clinical features to distinguish KRAS mutation status. Four feature selection methods and four deep learning classifiers were employed. Data was split into 70% training and 30% test sets, with SMOTE addressing imbalance in the training set. Model performance was evaluated using AUC, accuracy, precision, F1 score, and recall. Results: The analysis revealed that 10.4% of patients showed KRAS mutations. The study extracted 1061 radiomics features and combined them with 17 clinical features. After feature selection, two signatures were constructed using top 10, 20, and 50 features. The best performance was achieved using Multilayer Perceptron with 20 features. CECT, it showed 66% precision, 76% recall, 69% F1-score, 84% accuracy, and AUC of 93.3% and 87.4% for train and test sets, respectively. For NECT, accuracy was 85% and 82%, with AUC of 90.7% and 87.6% for train and test sets, respectively. Conclusions: CT-based radiomics signature is a noninvasive method that can predict KRAS mutation status of LADC when mutational profiling is unavailable.
Aurora-A promotes lenvatinib resistance experimentally through hsa-circ-0058046/miR-424-5p/FGFR1 axis in hepatocellular carcinoma
Authors: Abudoureyimu Mubalake , Sun Ni , Chen Weiwei , Lin Xinrong , Pan Fan , Wang Rui 
Published: February 2025

Objective: This study aimed to investigate whether the dysregulation of Aurora-A is involved in lenvatinib resistance in hepatocellular carcinoma. Methods: Bioinformatics tools and drug sensitivity assays were used to investigate the association between Aurora-A expression level and lenvatinib resistance in hepatocellular carcinoma cell lines. Cell function experiments had performed after treatment with lenvatinib and/or a selective Aurora-A inhibitor (MLN-8237). CircRNA microarray, RIP, RNA pull-down, and dual-luciferace reporter assay were performed to identify the downstream molecular mechanism of Aurora-A dysregulation. Results: Aurora-A expression was positively correlated with lenvatinib resistance in hepatocellular carcinoma cells. The Aurora-A selective inhibitor MLN-8237, in combination with lenvatinib, synergistically inhibited hepatocellular carcinoma cell proliferation in vitro and vivo, suggesting the Aurora-A might be a potential therapeutic target for lenvatinib resistance. Mechanistically, Aurora-A induced FGFR1 expression through the hsa-circ-0058046/miR-424-5p/FGFR1 axis. Aurora-A promotes lenvatinib resistance through hsa-circ-0058046/miR-424-5p/FGFR1 axis in hepatocellular carcinoma cells. The simultaneous inhibition of FGFR1 by the Aurora-A inhibitor MLN-8237 and lenvatinib overcame lenvatinib resistance in hepatocellular carcinoma cells. Conclusion: Collectively, our findings indicate that Aurora-A promotes lenvatinib resistance through the hsa-circ-0058046/miR-424-5p/FGFR1 axis in hepatocellular carcinoma (HCC) cells. These results suggest that Aurora-A may serve as a therapeutic target for HCC patients exhibiting lenvatinib resistance. Furthermore, the combination of lenvatinib and MLN-8237 shows potential for clinical trials aimed at overcoming lenvatinib resistance.
Integrated design and performance study of microwave absorption and load bearing for an embedded honeycomb superstructure
Authors: Wu Runxin , Li Fang , Liang Hao , Zhang Haiyu , Kong Xiangshao 
Published: February 2025

Compared with coated absorbing materials, honeycomb absorbing structural have raised widespread attention due to their better impedance matching, ability to provide multiple reflections and serve as mechanical structures. However, traditional honeycomb structure still has a huge space for improvement under the traction of wide and strong absorption performance, as well as the consideration of thin and light structural design. This article takes the developed multi-walled carbon nanotubes/carbonyl iron/epoxy resin composite material(MWCNT/CI/EP) as the absorbing material, and then embeds it into the traditional honeycomb absorbing structure through a special multi-scale superstructure design to acquire a new type of honeycomb superstructure that combines excellent absorbing performance and mechanical properties. The influencing factors such as structural parameters, incident angles, and polarization modes on the absorption performance of this superstructure was studied through simulation analyses. Research has shown that the designed embedded honeycomb superstructure can achieve full frequency coverage of less than −10 dB within 2-18 GHz, with a minimum of −39 dB, a maximum of −10.4 dB and an average level of −18 dB. The embedded honeycomb superstructure designed in this article has made breakthroughs in terms of absorption and mechanical properties compared to honeycomb structures with the same areal density, providing a certain inspiration for the research of structural and functional composite design.