bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activities and concentration of alpha-1 antitrypsin and cystatin C in serum from patients with house dust mite asthma
Authors: Hidayati Mailani Dwi , Iswanti Febriana Catur , Djauzi Samsuridjal , Koesnoe Sukamto , Sadikin Mohamad 
Published: February 2024

Background:
The proteolytic activities of house dust mite (HDM) allergens are involved in the pathogenesis of asthma by cleaving T-junction protein complexes, increasing the permeability of airway epithelial cells, and enabling the allergens to reach the interstitial tissue. The human body contains natural protease inhibitors such as alpha-1 antitrypsin (AAT) with antiserine protease activity and cystatin C with anticysteine protease activity.

Objective:
This study aimed to investigate the behavior of serum AAT and cystatin C levels in patients with HDM-allergic asthma.

Methods:
Ten individuals with HDM-allergic asthma and 10 healthy volunteers participated in a cross-sectional study. The serum AAT and cystatin C inhibitory activities were measured using enzymatic assays. ELISA was used to determine the serum AAT and cystatin C concentrations.

Results:
Serum AAT inhibitory activity (P = 0.445; P > 0.05), AAT concentration (P = 0.290; P > 0.05), and cystatin C concentration (P = 0.419; P > 0.05) did not significantly differ between the patient and control groups. However, serum cystatin C inhibitory activity in the asthmatic patient group was significantly higher than in the healthy subjects (P = 0.001; P < 0.05). There was no correlation between AAT inhibitory activity and AAT concentration or between cystatin C inhibitory activity and cystatin C concentration.

Conclusion:
These findings suggest that serum cystatin C activity is involved in asthma pathogenesis. Additional research is required to address this issue.
Perspectivas Quirúrgicas del Hemotorax : Abordaje y Resultados en la Cirugía General
Authors: Navarro Laguna Jaime Andrés , Guevara Suárez Katerine Elizabeth , Cedeño Farias Gema Marianela , Jami Suárez Génesis Michelle , Coronel Sánchez Kristhel Leonela , Martínez Gutiérrez José Andrés , Gualancañay Zurita Yosselin Yolanda 
Published: February 2024

Introducción: El hemotórax es una patología constituye un problema de salud y pone en peligro la vida del paciente si no se diagnostica y trata a tiempo. Un examen físico exhaustivo es importante para descartar lesiones que requieran tratamiento de emergencia. Además de prevenir complicaciones, tomamos en del estado general de los pacientes para lugar seleccionar los métodos adecuados de diagnóstico clínico y tratamiento
Desarrollo: El desarrollo aborda todo lo relacionado con las perspectivas quirúrgica del hemotórax. Además, se aborda la etiología, diagnóstico, tratamiento, fisiopatología, complicaciones y los resultados en la cirugía general. Llegando a la conclusión. con las futuras líneas de investigación con respecto a la temática abordada en el artículo.
Conclusiones: El diagnóstico temprano es clave en la evolución del hemotórax. La enfermedad conlleva un riesgo no despreciable de complicaciones que pueden poner en riesgo la vida de los pacientes o permanecer con secuelas que incidan en una mala calidad de vida. Por lo que la patología se debe estudiar a profundidad, ya que su presentación clínica es dinámica y compleja.
Nalazi iz kneževskog tumula Gruda Boljevića u Podgorici, Crna Gora
Authors: Govedarica Blagoje , Baković Mile 
Published: February 2024

Na području Crne Gore se u zadnjih pedesetak godina stalno iznova ot­krivaju monumentalne humke s bogatim grobovima iz vremena ranog bron­zanog doba. Prva takva humka pojavila se u Rubezima kod Nikšića 1952. godine. Godine 1976. obavljena su iskopavanja tumula Mala Gruda u Ti­vatskom Polju, a otkriće bogatih grobova u obliznjem tumulu Velika Gruda uslijedilo je 1991. godine. Konacno 2001. godine je istrazen tumul Gruda Boljevica u Podgorici. Dakle do sada su poznate četiri ovakve humke, ali po svemu sudeci to je samo trenutno stanje i to neće biti njihov konačan broj. Ove četiri do sada otkrivene humke pokazuju istovjetne kulturoloske karak­teristrike i sve se nalaze na području ,Jadranske obale i njenog neposrednog kraškog zaleđa i to u okviru jednog trougla čije stranice ne prelaze dužinu od 40 km.
Fruhformen des Geldes im bronzezeitlichen Europa
Authors: Hänsel Bernhard 
Published: February 2024

Der durch die intensivere Metallnutzung seit der fortgeschrittenen Frühbronzezeit bedingte Wirtschaftsverkehr dürfte sieh über das einfache Tauschen und Schenken zu einem komplexeren Warenverkehr entvvickelt haben, der ohne das regelhafte, bewertende Messen oder Taxieren von Gütern kaum ausgekommen sein dürfte. Bestimmte Gegenstande bekamen in mehr oder weniger groBen Raumen zu ihrer Primarfunktion eine zweite, namlich eine Verwendung als Werte bemessende Verkehrseinheit im Warentausch. Sie wurden als Geld eingesetzt, ohne ihre ursprüngliche Bedeutung und Vervvendung verloren zu haben. So ist zum Beispiel für die frühbronzezeitlichen, durch ganz Mitteleuropa verbreiteten Osenhalsringe wiederholt vermutet und wahrscheinlich gemacht worden, dass sie in ihrer Einheitlichkeit im Gewicht, ihrer meist rohen, zum Tragen um den Hals nicht verwendbaren Form sowie wegen ihres haufigen Vorkommens in groBen Depotfunden am ehesten einen Einsatz als frühes Geld, als Tauschwerteinheit, Verwendung gefunden haben. Sie dürften auch als Barren gedient haben. deren Wert wegen des gleich bleibenden Gevvichtes wieder erkannt und abgeschatzt werden konnte. Die enge Bindung an die Primarfunktion als Halsring lasst sich recht gut an Hand der Stücke erkennen, die bezeichnendervveise im peripheren Verbreitungsgebiet gefunden worden sind. Dort sind die Halsringe tatsachlich auch noch zum Tragen am Hals sauber geglattet und zu Colliers zusammengesetzt umgelegt worden.
CIVES COLONIAE RIS...? Likovi s antičkih epigrafskih spomenika rogatičko-romanijskog područja
Authors: Mesihović Salmedin 
Published: February 2024

Prostor današnje Rogatice je u antičko doba bio mjesto gdje se dizalo urbano i upravno jezgro jedne municipalne jedinice. U starijem željeznom dobu pa do otprilike kraja IV st. p. n. e. romanijsko područje i općenito jugoistočna Bosna bili su područje rasprostiranja Glasinačke kulture i vjerovatno su ulazile u okviru autarijatske politije. Međutim, u mlađe željezno doba šireglasinačko područje je izgleda bilo znatno manje naseljeno, dok se istovremeno zapadno nalazila moćna i značajna dezitijatska politija'. Vjerovatno se zona dezitijatske neposredne vlasti i glavne naseljenosti nije pružala dalje prema istoku od Romanije, odnosno u rogatičko područje porječja Rakitnice, pritoke Prače. Rimska vlast je prvi put bila uspostavljena vjerovatno 33. god.p. n. e., a obnovljena i konačno konsolidirana nakon ugušenja Velikog Ilirskog ustanka u kasno ljeto i ranu jesen 9. god. n. e. U teritorijalno-upravnom smislu rogatičko-romanijsko područje je pripadalo provinciji Ilirik (Illyricum) a nakon podjele jedinstvene Provincije pripalo je Dalmaciji (Gornji Ilirik - Illvricum Superior).
"Dezidijati": Identitetski konstrukt između antičkih i suvremenih percepcija
Authors: Džino Danijel 
Published: February 2024

Dezidijati nisu imali “sreću” poput nekih drugih željeznodobnih skupina zapadnog dijela jugoistočne Europe da privuku veću pažnju suvremenih znanstvenika. Za razliku od “popularnijih” Delmata ili Japoda, postoji svega nekolicina temeljnih studija koje su se bavile arheologijom željeznodobne sređnjobosanske arheološke kulture ili povijesti skupine koja se u antici nazivala Dezidijatima. Nekolicina je razloga za to - ponajviše nedostatan kvalitet i kvantitet istraživanja ostataka materijalne kulture, ali također i minimalna zastupljenost ove skupine u antičkim pisanim vrelima. Kroz primjer dezidijatske skupine, ovaj rad će nastojati upozoriti na šire probleme koji se sve više nameću prigodom izučavanja indigenih zajednica kasnog željeznog doba u regionu koji je tijekom vremena rimski kolonijalni zemljopis konstruirao kao “Ilirik". Najveći problem predstavlja raskorak zmeđu trenutačno dominirajućih modernističkih gledanja na pretpovijesne identitete ovog regiona i suvremenog pristupa izučavanju srodnih zajednica kontinentalne Europe, odnosno mediteranskog svijeta. Ova nesuglasnost sprječava uspješno uključivanje regionalne znanosti u širi dijalog o procesu integracije ovih željeznodobnih skupina u globalni mediteranski svijet ntičkog doba kroz širenje političkog okvira rimskog carstva.
The effectiveness of maternal pertussis vaccination for protecting Aboriginal and Torres Strait Islander infants against infection, 2012–2017: a retrospective cohort study
Authors: McHugh Lisa , D’Antoine Heather A , Sarna Mohinder , Binks Michael J , Moore Hannah C , Andrews Ross M , Pereira Gavin F , Blyth Christopher C , Van Buynder Paul , Lust Karin , Regan Annette K 
Published: February 2024

AbstractObjectivesTo evaluate the effectiveness of maternal pertussis vaccination for preventing pertussis infections in Aboriginal and Torres Strait Islander infants under seven months of age.Study designRetrospective cohort study; analysis of linked administrative health data.Setting, participantsMother–infant cohort (Links2HealthierBubs) including all pregnant women who gave birth to live infants (gestational age ≥ 20 weeks, birthweight ≥ 400 g) in the Northern Territory, Queensland, and Western Australia during 1 January 2012 – 31 December 2017.Main outcome measuresProportions of women vaccinated against pertussis during pregnancy, rates of pertussis infections among infants under seven months of age, and estimated effectiveness of maternal vaccination for protecting infants against pertussis infection, each by Indigenous status.ResultsOf the 19 892 Aboriginal and Torres Strait Islander women who gave birth to live infants during 2012–2017, 7398 (37.2%) received pertussis vaccine doses during their pregnancy, as had 137 034 of 259 526 non‐Indigenous women (52.8%; Indigenous v non‐Indigenous: adjusted odds ratio, 0.66; 95% confidence interval [CI], 0.62–0.70). The annual incidence of notified pertussis infections in non‐Indigenous infants declined from 16.8 (95% CI, 9.9–29) in 2012 to 1.4 (95% CI, 0.3–8.0) cases per 10 000 births in 2017; among Aboriginal and Torres Strait Islander infants, it declined from 47.6 (95% CI, 16.2–139) to 38.6 (95% CI, 10.6–140) cases per 10 000 births. The effectiveness of maternal vaccination for protecting non‐Indigenous infants under seven months of age against pertussis infection during 2014–17 was 68.2% (95% CI, 51.8–79.0%); protection of Aboriginal and Torres Strait Islander infants was not statistically significant (36.1%; 95% CI, –41.3% to 71.1%).ConclusionsDuring 2015–17, maternal pertussis vaccination did not protect Aboriginal and Torres Strait Islander infants in the NT, Queensland, and WA against infection. Increasing the pertussis vaccination rate among pregnant Aboriginal and Torres Strait Islander women requires culturally appropriate, innovative strategies co‐designed in partnership with Indigenous organisations and communities.
Use of Concentrated Solar Power Technology for a High Temperature Processes: Case Study of Uzbekistan
Authors: Payzullakhanov Mukhammad-Sultan , Akbarov Rasul , Suvonova Lola 
Published: February 2024

The paper examines the state and prospects for the development of renewable energy use in Uzbekistan, presents the specific features and conditions of concentrated solar power (CSP) technology, analyzes the technological capabilities of high-temperature solar furnaces as one of the promising areas of CSP technology, and notes specific scientific directions in this area. A comparative analysis of the technical and optical-energy characteristics of high-temperature solar furnaces of well-known research centers and their application in solving of actual scientific and technical problems is carried out. The main parameters and energy characteristics of the Uzbek 1000 kWt solar furnace in Parkent (BSF) in comparison with the similar French (Odeillo) furnace are given. Special equipment and stands installed in the focal zone of the furnace for melting, synthesis, heat treatment and complex testing of various technical products in high-temperature conditions are presented. By the example of the analysis of the process of quenching high-temperature materials, some features of high-temperature processes are shown.
Kyphoscoliosis complicating asthma with fixed airway obstruction
Authors: Bonello Sarah , Farrugia Yanika , Mallia Theresa , Maniscalco Nicoletta , Balzan Martin 
Published: February 2024

Introduction: Kyphoscoliosis is present in up to 2% of the juvenile population and can have deleterious effects on respiratory mechanics, leading to chronic respiratory failure later on in adult life. Case presentation: Hereby we describe a 53-year-old patient with severe uncontrolled asthma who presented with chronic hypercapnic respiratory failure. During her medical workup, she was noted to have several comorbidities leading to her respiratory failure. The patient had radiological evidence of bronchiectasis with recurrent episodes of infection, and a severe deformity of the spine due to Kyphoscoliosis. Probably the kyphotic component of this deformity had worsened due to a long history of oral steroid use leading to severe osteoporosis and consequent vertebral compression fractures reaching a Cobb angle of 73 degrees. This was probably caused by the patient’s non-compliance with inhaler therapy and an excessive reliance on oral steroid use. Her respiratory failure was treated with domiciliary noninvasive positive pressure ventilation and 24-hour oxygen therapy and her symptoms improved. Conclusion: A multidisciplinary approach across different specialities is necessary when managing such a patient with kyphoscoliosis, bronchiectasis, asthma with airflow limitation with respiratory failure.
University technology transfer: &#39;it&#39;s not a business, but run it like a business‘
Authors: Nooijer Ivo de 
Published: February 2024

<strong>
I’ for invention
</strong>
Academic researchers and inventors are explorers – boldly going where no one has gone before. Most people agree on this. However, the relevance of their discoveries or breakthroughs is perceived very differently by different groups, at least when it comes down to technology transfer of that invention from universities to companies.
Utilization of immediate postpartum family planning among women in Homabay and Vihiga Counties
Authors: Erick Odipo , Muhambe Cynthia , Odila Paul , Ndenga Alinda , Hassan Nyawanga  , Dan Rambo  , Veronica Musiega  
Published: February 2024

Background: Family planning (FP) integration in other services is essential to address unmet FP needs among postpartum women and reduce the risks of short pregnancy intervals. Immediate postpartum family planning (PPFP) is an established high-impact practice. This study aimed to assess the uptake of immediate PPFP utilization before and after implementation in various project interventions.
Methods: Capacity building of 276 health care providers was conducted in 100 facilities by 32 established FP mentors through facility-based mentorship, emphasizing quality counseling. PPIUCD sets were procured and distributed to 80 facilities. 165 health care workers were oriented on facility consumption data reports and requests (FCDRR) to improve commodity availability. Monthly FP dashboard meetings were held at the subcounty level. FP registers were availed in postnatal wards, and messaging and FP referrals were performed by community health volunteers. For voluntarism, FP compliance sessions were conducted with service providers, and PPFP quality improvement approaches were implemented in eight facilities.
Results: 927 and 542 women received immediate PPFP in Homa Bay and Vihiga Counties, respectively, accounting for 11% and 17% of women who delivered in the facilities. The proportion of women who delivered in the facilities received PPFP within 48 hours changed one year later, with 397 women or 3.8% of deliveries between October and December 2021. Health facility baseline assessment demonstrated gaps in the uptake of contraceptives in the immediate postpartum period, including inadequate counseling during antenatal care, lack of postpartum intrauterine device (IUD) insertion skills, lack of PPIUD kits, and lack of commodities and of reporting tools.
Conclusion: The untapped demand for immediate PPFP can be met through targeted interventions to improve access and quality of the service.
Lipschutz ulcers – acute genital ulceration in a 17-year-old: A case report
Authors: Adongo Susan AD , Tracy Foran  , Sonia Grover  
Published: February 2024

Background: The diagnosis of genital ulcers remains a challenge. Lipschutz ulcers are rare, painful, necrotic, and underdiagnosed lesions that are often found in nonsexually active adolescent females. The onset is acute and follows the prodromal phase of viral illness. Pathogenesis is unclear, but a hypersensitivity reaction to viral or bacterial infection leads to the deposition of an immune complex in the dermal vessels. The disease is self-limiting over two to six weeks.
Case presentation: A 17-year-old female presented to the Emergency Department at the Royal Children’s Hospital, Melbourne with painful genital ulcers for five days and acute urinary retention for two days. This was preceded by a flu-like illness a week prior with associated body heat and polyarthralgia. The patient denied any history of sexual activity. There was no relevant medical history, no use of regular medication, and no history of trauma or sexual abuse. Perineal examination revealed “kissing” vulval lesions, 1 cm each, on the lower aspect of the labia majora. The lesions were symmetric with an erythematous border and a necrotic base. Sexually transmitted illness screening and her autoimmune profile were negative. Epstein-Barr virus IgG was positive and inflammatory markers were mildly elevated. Genital culture reported mixed anaerobes. The patient was catheterized, and administered local and systemic analgesia, steroid cream, and oral antibiotics. Wound care was instituted three times a day. She was discharged home after five days to complete medication once she was pain-free and able to pass urine.
Conclusion: The diagnosis of Lipschutz ulcer is an exclusion and other causes of genital ulceration such as genital herpes, sexually transmitted infections, and autoimmune diseases must first be ruled out. Healing without scarring is spontaneous, and management involves wound care, local and systemic analgesia, local corticosteroids, and antibiotics if there is evidence of secondary infection.
Análisis de estrategias de actualización de repositorios digitales a DSpace 7
Authors: De Albuquerque Pablo , Tettamanti Santiago , Villarreal Gonzalo Luján , Lira Ariel Jorge , De Giusti Marisa Raquel 
Published: February 2024

This paper analyzes different strategies that can be applied when upgrading a digital repository from DSpace 6 or earlier to DSpace 7. An analysis of this software is made, with emphasis on the architectural and functional differences of the different versions. Then, the experience obtained from the upgrade to DSpace 7 of the CIC DIGITAL repository is described, detailing the path followed throughout the process and highlighting the conflicts that arose during this process, related to the upgrade of the source code and the software platform as well as to the migration of data to the new schema proposed by DSpace 7. Finally, the paper reflects on the different strategies for adopting this software for the different scenarios in which a digital repository that intends to undertake a migration of similar characteristics may find itself.
En este trabajo se analizan distintas estrategias que se pueden aplicar a la hora de actualizar un repositorio digital desde DSpace 6 o anterior hacia DSpace 7. Se realiza un análisis de dicho software, con énfasis en las diferencias arquitecturales y funcionales de las distintas versiones. Luego se describe la experiencia obtenida a partir de la actualización a DSpace 7 del repositorio CIC DIGITAL, para lo cual se detalla el camino seguido a lo largo del proceso y se remarcan los conflictos que surgieron durante este proceso, vinculados tanto a la actualización del código fuente y de la plataforma de software así como también a la migración de los datos hacia el nuevo esquema propuesto por DSpace 7. Finalmente, se reflexiona sobre las distintas estrategias de adopción de este software para los distintos escenarios en los que puede encontrarse un repositorio digital que pretenda encarar una migración de características similares.
Este artigo analisa as diferentes estratégias que podem ser aplicadas na atualização de um repositório digital do DSpace 6 ou anterior para o DSpace 7. É feita uma análise do software, com ênfase nas diferenças arquitectónicas e funcionais entre as diferentes versões. Em seguida, descreve-se a experiência obtida com a atualização para o DSpace 7 do repositório CIC DIGITAL, detalhando o caminho percorrido ao longo do processo e destacando os conflitos que surgiram durante este processo, relacionados tanto com a atualização do código fonte e da plataforma de software como com a migração dos dados para o novo esquema proposto pelo DSpace 7. Finalmente, reflecte-se sobre as diferentes estratégias de adoção deste software para os diferentes cenários em que se pode encontrar um repositório digital que pretenda realizar uma migração de características semelhantes.
The relationship school-society, theory-practice seen from the analysis of the curriculum
Authors: Sánchez-Arguelles Itzel Guadalupe 
Published: February 2024

In this article five possible perspectives, not exclusive, are exposed to approach the curriculum, which answer the question what the curriculum is and what its nature is. This approach leads to the conclusion that delimiting it is to restrict its complexity and richness as a social practice, specifically in the field of formal or schooled practice, since it expresses the School-Society, Theory-Practice relationship and the role of its actors in the dynamics of educational institutions. Keywords: Curriculum, programme, educational practice. RESUMEN En el presente artículo se exponen cinco perspectivas posibles, no excluyentes, para abordar el currículo, las cuales responden al interrogante qué es el currículo y cuál es su naturaleza. Este abordaje lleva a concluir que delimitarlo es restringir su complejidad y su riqueza como práctica social, específicamente en el campo de la práctica formal o escolarizada, pues expresa la relación Escuela-Sociedad, Teoría-Práctica y el rol de sus actores en la dinámica de las instituciones educativas. Palabras clave: Currículo, plan de estudio, práctica educativa.