bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure
Authors: Zhao Zhenyu , Hu Zhixi , Li Lin 
Published: February 2025

ObjectiveTo investigate the relationship between heart failure (HF) and gut microbiota-mediated energy metabolism, and to explore the role of Shenfu Injection in this process.Materials and methodsIn this study, Adriamycin-induced chronic heart failure (CHF) rat model was used and randomly divided into the blank control group (Normal, n = 9), HF control group (Model, n = 12), Shenfu Injection treatment group (SFI, n = 9), and positive drug control group (TMZ, n = 9). The changes in gut microbiota structure were analyzed by 16S rRNA high-throughput sequencing, the content of short-chain fatty acids (SCFAs) was detected by targeted metabolomics technology, and cardiac function and energy metabolism-related indicators were evaluated.ResultsMyocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.ConclusionShenfu Injection in treating HF may improve myocardial energy metabolism and intestinal health by regulating gut microbiota, especially the abundance of SCFAs-producing bacteria Akkermansia and Blautia, thereby exerting therapeutic effects. This provides theoretical support for treatment strategies based on gut microbiota.
Developing a strategic action plan for reducing the burden of stroke in Africa: report of the first African Stroke Leaders' Summit
Authors: Akinyemi Rufus , Olowoyo Paul , Jones Stephanie , Adeniji Olaleye , Ogunde Gabriel , Spencer Joseph , Abd-Allah Foad , Akpalu Albert , Lightbody Liz , Yaria Joseph , Sarfo Fred S. , Naidoo Pamela , Belson Sarah , Ebenezer Ad Adams , Nasreldein Ahmed , Makanjuola Akintomiwa , Saylor Deanna , Zimba Stanley , Ojewale Lucia , Youkee Daniel , Adoukonou Thierry , Okekunle Akinkunmi , Anyanwu Benjamin , Okubadejo Njideka , Bateman Kathleen , Melifonwu Rita , Obiako Reginald , Arulogun Oyedunni , Wahab Kolawole W. , Adebayo Philip , Francis Patty , Ossu-Nguiet Paul , Charway-Felly Augustina , Ogbole Godwin , Ogun Shamsideen , Walker Richard , Gebreyohanns Mehari , Langhorne Peter , Norrving Bo , Ovbiagele Bruce , Kalaria Rajesh N. , Ogunniyi Adesola , Watkins Caroline Leigh , Owolabi Mayowa 
Published: February 2025

IntroductionStroke is a leading cause of adult neurologic disability, cognitive decline, and death worldwide, and particularly in Africa. Stroke research in Africa has exposed challenges militating against the translation of research evidence into practice and policy. The evidence-based, context-sensitive multilevel strategies required to surmount these challenges are presented in this report on the first African Stroke Leaders' Summit (ASLS) organized to tackle the burden of stroke in Africa.MethodsThe Africa–UK Stroke Partnership (AUKSP) Project had a Steering Committee (SC) and four theme-based Working Groups (WGs): stroke services, stroke training/capacity building, research and stroke advocacy, each with defined terms of reference. These groups generated 20 priorities (five per thematic area) during breakout sessions at the first ASLS which were further refined into four topmost priorities (one per thematic area) at the general consensus session.ResultsThe topmost priorities included promoting the development of acute stroke services (stroke services), strengthening population-based stroke education focusing on prevention and symptom recognition (stroke training), research on hypertension control to reduce stroke risk (stroke research), and developing national stroke action plans (advocacy).ConclusionSustained reduction of stroke burden in Africa requires the adaptation of best practices to the African context, building the capacity of African stroke care professionals and using available resources with political support. Improving stroke literacy in African communities is a complementary strategy to reinforce healthy lifestyle choices and improve screening and detection of hypertension and other modifiable stroke risk factors. This process will culminate in a strategic African Stroke Action Plan (ASAP), the blueprint for the control of stroke in Africa.
Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the Staphylococcus aureus 1199B Strain
Authors: Roque Paulo Cicera Laura , Alexandre Priscilla Ramos Freitas , Araujo Ana Carolina Ferreira , Almeida Ray Silva , Albuquerque Emílio Sousa , Oliveira-Tintino Cícera Datiane de Morais , Nascimento Igor J. S. , Araújo-Júnior João Xavier , Silva-Junior Edeildo Ferreira da , Aquino Thiago Mendonça de , Mendonça-Junior Francisco Jaime Bezerra , Araújo-Neto José Bezerra de , Silva Leandro Maria Karollyna do Nascimento , Menezes Irwin Rose Alencar de , Coutinho Henrique Douglas Melo , Rocha Janaina Esmeraldo 
Published: February 2025

Background: Substances with antibacterial properties have become crucial in light of the continuous increase in infections caused by multidrug-resistant bacteria. In this context, thiadiazines have emerged as heterocyclic compounds already known for their pharmacological activities. However, their potential as antibacterial agents and inhibitors of the efflux system found in resistant bacteria remains poorly understood. From this perspective, the present study highlights the synthesis of thiadiazine-derived compounds and evaluates their antibacterial activity and efflux pump inhibition against the Staphylococcus aureus 1199B strain. Methods: To this end, Minimum Inhibitory Concentration (MIC) tests were conducted, along with the analysis of antibacterial activity through the inhibition of the NorA efflux system using 96-well microdilution assays. Additionally, to assess efflux system inhibition, ethidium bromide (EtBr) fluorescence emission tests were performed, alongside in silico molecular docking studies. Results: Based on the results obtained, it was observed that compound IJ28 exhibited direct activity against the tested SA 1199B strains, with an MIC of 512 µg/mL. It also demonstrated antibacterial activity through efflux pump inhibition, resulting in increased fluorescence rates emitted by EtBr. Compound IJ28 showed a more significant reduction in the Minimum Inhibitory Concentration (MIC) of ethidium bromide, decreasing from 26.6 µg/mL to 0.5 µg/mL, compared to the other compounds. Conclusions: Therefore, it is essential to conduct further studies to investigate the mechanism of action and clarify the feasibility and effects of compound IJ28 as a potential antibacterial agent.
Análise comparativa entre apendicectomia via aberta e videolaparoscópica no Brasil na última década
Authors: Oliveira Carlos Eduardo de Melo , Sousa Iara Bernardino de , Brasilino Carla Emanoela de Melo , Cordeiro Ellen Maria de Sousa , Tavares Aretha Holanda , Oliveira Maria Clara Lopes Cordeiro de , Monteiro Leonardo Barroso , Lobo Anna Beatriz Nobre , Ximenes Beatriz Paiva de Carvalho , Souza Thayana Cruz de 
Published: February 2025

A apendicite é uma inflamação do apêndice vermiforme que geralmente requer intervenção cirúrgica, seja por via aberta ou videolaparoscópica. O estudo tem como objetivo comparar as características e desfechos da apendicectomia realizada por via aberta e videolaparoscópica. A pesquisa possui caráter descritivo, quantitativo e retrospectivo, para a qual utilizou-se dados secundários, coletados em janeiro de 2025. Utilizou-se cálculos de frequência absoluta e relativa, média, razão de prevalência e teste qui-quadrado de Pearson. No decênio, foram realizadas 1.140.561 apendicectomias no Brasil, sendo 93,4% por via aberta e 6,6% por via laparoscópica. O total de óbitos foi de 2.722 na via aberta e 57 na videolaparoscopia. Ademais, o TPMH e o valor médio da AIH foram, respectivamente, 2,9 dias e R$ 677,75 para a videolaparoscopia, e 3,3 dias e R$ 616,20 para a via aberta. Observou-se menor tempo de internação, menor taxa de mortalidade e maior valor médio AIH entre os procedimentos realizados por laparoscopia. Apesar disso, a cirurgia aberta ainda é mais comum no Brasil. A comparação entre as técnicas mostrou associação significativa entre a apendicectomia aberta e maior prevalência de óbitos.
Main interdental papilla reconstruction techniques: literature review
Authors: Ferreira Rayla Cristina da Costa , Rezende Mariana Gomes , Montanha Ivan Queiroz , Falabella Márcio Eduardo Vieira , Sotto-Maior Bruno Salles , Resende Leandro Marques de 
Published: February 2025

Dentistry has sought harmony between “white” and “pink” aesthetics, especially in areas with greater aesthetic appeal. The interdental papillae, especially in the anterior maxillary region, play a crucial role, and their absence generates dissatisfaction. A literature review was carried out to identify the main techniques used in interdental papilla reconstruction, as well as their predictability and stability over time. 27 articles were included, which reported that there are invasive or non-invasive techniques for augmenting/reconstructing the interdental papilla. These include connective tissue; platelet-rich fibrin; roll technique, roll technique after recontouring with composite resin; tunnel technique with subepithelial connective tissue; semilunar incision with subepithelial connective tissue; subepithelial connective tissue of the palate and tuberosity associated with composite resin restorations; I-PRF; connective tissue graft and coronally advanced flaps; subepithelial connective tissue graft and PRF in the surgical reconstruction of the interdental papillae using the Han and Takei technique and hyaluronic acid. Although some information is agreed upon in the scientific literature, such as the definition of the presence and absence of papillae, and how they are classified. As far as reconstruction techniques are concerned, there are a variety of forms, most of which are unpredictable, with the subepithelial connective tissue graft being considered the most predictable over time. However, studies with a longer observation period are scarce in the literature.
Edytorial
Authors: Bigaj-Zwonek Beata , Stankiewicz-Kopeć Monika , Szanduła Michał 
Published: February 2025

Temat kultury studenckiej – zaś w tym kontekście także i kultury akademickiej – cieszy się znacznym zainteresowaniem badawczym, czego przykładem jest niniejszy zbiór artykułów zogniskowanych wokół zagadnień związanych z jej dziejami i teraźniejszością. Jednocześnie zagadnienia łączące się ze zjawiskiem kultury studenckiej wywołują współcześnie wiele dyskusji i polemik, w których biorą udział zarówno badacze tego zjawiska, jak i jego dokumentaliści, twórcy ruchu studenckiego (z czasów Polskiej Rzeczpospolitej Ludowej), a także jego współcześni animatorzy.
Editorial
Authors: Bigaj-Zwonek Beata , Stankiewicz-Kopeć Monika , Szanduła Michał 
Published: February 2025

The topic of student culture – and, in this context, academic culture – has garnered significant research interest, as demonstrated by this collection of articles exploring their historical development and contemporary state. At the same time, discussions about the nature of student culture today spark considerable debate and critique, engaging not only researchers who study this phenomenon but also documentarians, creators of the student movement (particularly from the era of the Polish People’s Republic), and its modern-day and organizers.
Spotkanie biskupa Iwona Odrowąża ze św. Dominikiem z Caleruegi
Authors: Szurek Tomasz 
Published: February 2025

Autor ukazuje okoliczności i datę spotkania biskupa krakowskiego Iwona Odrowąża ze św. Dominikiem z Caleruegi. Źródła polskiego pochodzenia, takie jak Żywot św. Jacka autorstwa lektora Stanisława OP oraz Annales czy Liber beneficiorum Jana Długosza zostały skonfrontowane z przekazami zagranicznymi mówiącymi o tym wydarzeniu. Na tej podstawie autor ustalił, że najprawdopodobniej spotkanie to nastąpiło w Rzymie 12 lutego 1220 r. Wtedy to zapewne zapadła decyzja o sprowadzeniu członków Zakonu Kaznodziejskiego do Krakowa.
Klasztory żeńskie jako enklawy kobiecej niezależności
Authors: Kulesza Monika 
Published: February 2025

Artykuł posiada strukturę dwudzielną. W pierwszej jego części (po skondensowanym zarysowaniu najistotniejszych wystąpień Kościoła związanych z ruchem emancypacji) zostało ukazane, że na zakony żeńskie w perspektywie ich długiej historii można patrzeć jako na wspólnoty sprzyjające specyficznej „emancypacji” kobiet. Żeńskie klasztory, prócz misji konkretyzowania duchowego powołania, stanowiły bowiem także enklawy wolności od dominującego modelu życia, jaki w danym społeczeństwie był dla kobiet przewidziany (matki, żony, opiekunki domowego ogniska) oraz przestrzenie wolności tworzenia, rozwoju intelektualnego, dostępu do kultury piśmiennej0 i działalności artystycznej. W drugiej części pracy omówione zostały poczynania Marceliny Darowskiej i Józefy Karskiej (założycielek niepokalanek) pod kątem ich wkładu w walkę o godność kobiety w sferze nie tylko kościelnej, ale i społecznej, w poszerzanie kobiecej autonomii i niezawisłości, ukazane zostały także zmagania owych niepokalanek o solidne wykształcenie i samodzielność myślenia polskich kobiet. Artykuł akcentował te aspekty niepokalańskiej formacji, które wyprzedzały wiele XIX-wiecznych emancypacyjnych postulatów, a także wskazał w nauce Darowskiej krąg owych wartości, które Jan Paweł II określił później mianem „nowego feminizmu”.
Społeczno-kulturowe dysfunkcje turystyki w Egipcie na przykładzie małżeństw urfi
Authors: Gurga Iwona 
Published: February 2025

Celem artykułu jest ukazanie społeczno-kulturowych dysfunkcji turystyki w Egipcie na przykładzie małżeństw urfi. Dokonano tego poprzez analizę fenomenu małżeństwa zwyczajowego, zaadaptowanego na grunt turystyczny, i jego interpretację na tle tradycyjnego małżeństwa w kulturze islamu. Małżeństwa urfi mają charakter pozorny – w świetle prawa kobieta i mężczyzna nie są małżeństwem – jednak zawierane pomiędzy Egipcjanami a turystkami służą do legalizacji kontaktów seksualnych, dozwolonych w islamie jedynie w obrębie małżeństwa.
Marek Grechuta i płyty
Authors: Tański Paweł 
Published: February 2025

W artykule podjęto próbę analizy i interpretacji między innymi takich kwestii, jak formy dostępności płyt Marka Grechuty – na tradycyjnych nośnikach (tak zwane płyty winylowe, CD, kasety) i w serwisach muzycznych (Spotify, YouTube), konstrukcje układów utworów na albumach, czyli ich kolejność. Interpretacje dotyczą takich spraw, jak czasowość, realizacje sposobów poznawania i rozumienia piosenek, refleksja nad kompozycją płyt, wytwarzania i używania sensotwórczych systemów aksjonormatywnych dzięki kontemplacji muzyki, w tym muzyki popularnej. Artykuł wpisuje się w nurt badań popular music studies oraz song studies.
Investigation of interface trap characteristics in 3-D NAND flash memory with temperature dependency
Authors: So Donghyuk , Cho Yonggyu , Shim Hyunyoung , Sim Jaesung , Shin Hyungcheol 
Published: February 2025

Abstract
In this paper, the characteristics of interface traps (Nit) at poly-Si and bandgap-engineered tunneling oxide (BE-TOX) interface in 3-D NAND flash memory were investigated at various temperatures. Program and erase (P/E) cycling tests were carried out up to 30k with four different temperatures and recovery test for 60 minutes was conducted. The interface traps were analyzed using both the subthreshold swing (S.S.) method and technology computer-aided design (TCAD) simulation. Nit generation occurs due to cold hole (CH) tunneling and explained by reaction-diffusion (RD) model. The Nit generation follows a power-law relation with respect to the cycle counts. Additionally, Nit recovery behavior was well fitted to the stretched exponential function (SEF). The activation energy (Ea) was extracted from the recovery behavior. Also, temperature dependent hydrogen diffusion tendencies in the BE-TOX layer were observed through TCAD simulation.
Fabrication of 1700 V SiC MOSFETs with optimized JFET region and current spreading layer
Authors: Chen Guran , Li Shiyan , Zhang Teng , Tian Yuan , Li Feifei , Zhang Guobin , Ying Xianwei , Wei Lang , Bai Song , Yu Linwei , Wang Junzhuan 
Published: February 2025

Abstract
In this paper, the simulation, fabrication and characterization of high current density 1700V SiC MOSFETs with a hexagonal cell layout are reported. A novel SiC MOSFET structure incorporating step-type implantation in both the JFET region and CSL (JC-MOS) is developed to address the high resistance issues . Through optimized implantation conditions, a remarkable decrease in the Ron of 20.2% is realized. An ultra-low Ron of 15mΩ and a Ron,sp of 3.75mΩ·cm2 are achieved both of which are the lowest reported values for 1700 V SiC planar MOSFET devices to date. By reducing the JFET region width from 1.2μm to 0.9μm, the JC-MOS device Crss and the HF-FOM are reduced by 44.6% and 43.1%, respectively, while simultaneously increasing the Eav from 3.42J to 4.25J. Furthermore, the dependence of the JFET and CSL doping concentration on BV, avalanche tolerance and maximum Eox is analyzed using experimental and simulation results.
Water in Protoplanetary Disks with JWST-MIRI: Spectral Excitation Atlas and Radial Distribution from Temperature Diagnostic Diagrams and Doppler Mapping
Authors: Banzatti Andrea , Salyk Colette , Pontoppidan Klaus M. , Carr John S. , Zhang Ke , Arulanantham Nicole , Krijt Sebastiaan , Öberg Karin I. , Cleeves L. Ilsedore , Najita Joan R. , Pascucci Ilaria , Blake Geoffrey A. , Romero-Mirza Carlos E. , Bergin Edwin A. , Cieza Lucas A. , Pinilla Paola , Long Feng , Mallaney Patrick , Xie Chengyan , Waggoner Abygail R. , Kaeufer Till ,   the JDISCS collaboration
Published: February 2025

Abstract
This work aims at providing fundamental general tools for the analysis of water spectra as observed in protoplanetary disks with JWST-MIRI. We analyze 25 high-quality spectra from the JDISC Survey reduced with asteroid calibrators as presented in K. M. Pontoppidan et al. (2024). First, we present a spectral atlas to illustrate the clustering of H2O transitions from different upper-level energies (E

u
) and identify single (unblended) transitions that provide the most reliable measurements. With that, we demonstrate two important excitation effects: the opacity saturation of ortho-para line pairs that overlap, and the subthermal excitation of excitation of v = 1–1 lines scattered across the v = 0–0 rotational band. Second, we define a shorter list of fundamental lines spanning E

u
= 1500–6000 K to develop simple line-ratio diagnostic diagrams for the radial temperature distribution of water in inner disks, which are interpreted using discrete temperature components and power-law radial gradients. Third, we report the detection of disk-rotation Doppler broadening of molecular lines, which confirms the radial distribution of water emission including, for the first time, the radially extended ≈170–220 K reservoir close to the snowline. The combination of measured line ratios and broadening suggests that drift-dominated disks have shallower temperature gradients with an extended cooler disk surface enriched by ice sublimation. We also report the first detection of an H2O-rich inner disk wind from narrow blueshifted absorption in the ro-vibrational lines. We summarize these findings and tools into a general recipe to make the study of water in planet-forming regions reliable, effective, and sustainable for samples of >100 disks.
Cancer Survivorship and Subjective Cognitive Decline in the United States
Authors: Brown Monique J. , Holloway Jeremy , Bookbinder Morgan , Malatyali Ayse , Wei Jingkai , Southerland Jodi L. , Couch Elyse , Bacsu Juanita-Dawne , Smith Matthew Lee , Na Muzi 
Published: February 2025

Purpose
Studies examining the link between cancer survivorship and subjective cognitive decline (SCD) are lacking. Therefore, the current study aimed to determine the association between cancer survivorship and SCD among a nationally representative sample of middle-aged and older adults.

Method
Data were obtained from the 2021 Behavioral Risk Factor Surveillance System Survey. Crude and adjusted logistic regression models, controlling for age, gender, race/ethnicity, educational level, income, and work status, were used to determine the association between cancer survivorship characteristics and SCD.

Results
Respondents who were currently undergoing treatment had 86% higher odds of SCD (adjusted odds ratio [aOR] = 1.86; 95% confidence interval [CI] [1.06, 3.27]) compared to respondents who completed treatment. However, those who refused treatment were less likely to report SCD (aOR = 0.006; 95% CI [<0.001, 0.059]) compared to respondents who completed treatment.

Conclusion

Cognition interventions may be helpful for individuals diagnosed with cancer who are undergoing treatment, middle-aged, and have not started treatment. [
Journal of Gerontological Nursing, xx
(x), xx–xx.]
“Get a Grip, Get on With It, This Is Life”: A Qualitative Exploration of How Community-Dwelling Older Adults' Self-Manage Low Mood
Authors: Waterworth Susan , Pearson Caitlin , Raphael Deborah 
Published: February 2025

Purpose
Older adults have a strong desire to self-manage their overall well-being, including their mental health. However, there is a risk that low mood could be associated with aging, normalized and accepted, and impacts help-seeking behavior by older adults. Thus, the current study explored how older adults in New Zealand manage low mood.

Method
This qualitative descriptive study was embedded in a study exploring community-dwelling older adults' well-being. Semi-structured interviews were conducted with 37 older adults aged between 66 and 99 years (mean age = 83 years). Reflexive thematic analysis was used to analyze the data.

Results

Four themes emerged: (1)
Noticing, Normalizing, and Thinking Differently
; (2)
Engaging in Meaningful Activities
; (3)
Connecting With Others
; and (4)
Seeking Help
. Importantly, older adults developed positive ways of managing low mood.

Conclusion

Successful strategies older adults implemented can be shared, challenging stereotypes that low mood is specifically part of the aging process. For nurses, greater awareness of the strategies older adults use to combat low mood is vital to ensure they can maintain overall well-being. [
Journal of Gerontological Nursing, xx
(xx), xx–xx.]