bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Characteristics of Migraine and Episodic Tension‐Type Headache in Relation to Old and New Diagnostic Criteria
Authors: Iversen Helle K. , Langemark Michael , Andersson Poul Gertz , Hansen Per Evald , Olesen Jes 
Published: May 2005

SYNOPSISEighty‐one patients were diagnosed as having migraine, tension headache or both according to previously used criteria. Then we performed a standardized interview to determine the frequency and severity of headache characteristics used in the new operational diagnostic criteria of the International Headache Society (IHS). In every patient the original diagnosis fulfilled also the IHS criteria, but in 9 patients the criteria were only fulfilled in half or less of the attacks, and applying the IHS criteria they also achieved an additional diagnosis. In one patient these attacks did not fulfill the pain criteria and in 8 (4 migraine, 4 tension headache) they did not fulfill the criteria for accompanying symptoms. Overall the HIS criteria are sensitive and specific, but they may possibly be improved with regard to accompanying symptoms. The present study suggests that recording of frequency and graded severity of characteristics using a headache diary may further improve the distinction between the different types of headache.
Alteration of Platelet Serotonin in Patients with Chronic Tension‐Type Headache During Cold Pressor Test
Authors: Shimomura Tokio , Takahashi Kazuro 
Published: May 2005

SYNOPSISChange of 5‐hydroxytryptamine (5‐HT) concentrations in platelets from patients with chronic tension‐type headache (TH) and controls were observed during cold pressor test (CPT). Before cold stimulation, 5‐HT concentrations in platelets from patients with TH were significantly lower than those found in controls. One minute after the start of cold stimulation, 5‐HT levels in platelets from patients with TH were significantly much lower than in the controls, as control levels rose and TH levels fell. The results show that, under stress, the absorbance of 5‐HT into the platelets in patients with TH is reduced. It is suggested that, in patients with TH, there are abnormalities of 5‐HT uptake into platelets and factors which cause release of 5‐HT from platelets.
Assessment and Treatment of Children's Headaches from a Developmental Perspective
Authors: Marcon Rebecca A. , Labbé Elise E 
Published: May 2005

SYNOPSISChildhood headache is a common pediatric problem. Clinical researchers have evaluated several behavioral treatments, such as biofeedback and relaxation training, that may be viable interventions. Adding a developmental perspective to the evaluation and treatment of childhood headache is a likely way to increase the effectiveness of these strategies. This paper presents developmental issues related to the assessment and treatment of childhood headache. Three major areas of development are examined and the impact of these areas on the treatment and assessment of headache are discussed. The three major areas are cognitive development, self‐regulation and psychosocial development. Provided are practical suggestions for the application of child development principles to assessment and intervention practices that may be more developmentally appropriate.
Nocturnal Sleep Recording with Cassette EEG in Chronic Headaches
Authors: Drake Miles E. , Pakalnis Ann , Andrews Jodie M. , Bogner Janet E. 
Published: May 2005

SYNOPSISMany headache patients complain of poor sleep, and sleep disturbance has been shown to play a role in chronic pain. We recorded nocturnal sleep with a 4‐channel cassette EEG monitoring device in 10 common migraine patients, 10 individuals with muscle contraction (tension) headache, and 10 chronic tension‐vascular headache sufferers.Migraine patients had essentially normal sleep, although rapid eye movement (REM) sleep and REM latency were increased. Patients with tension headache had reduced sleep time and sleep efficiency, decreased sleep latency but frequent awakenings, increased nocturnal movements, and marked reduction in slow wave sleep, without change in REM sleep or latency. Mixed‐element headaches with both tension and vascular features were associated with reduced sleep, increased awakening, diminished slow wave sleep, and REM sleep that was decreased in amount and reduced in latency.The findings suggest that patients with intermittent migraine may have minimal sleep disturbance, while chronic headache may be worsened by chronically poor sleep. Muscle contraction headache may be associated with frequent awakenings and decreased slow wave sleep similar to the sleep changes of fibrositis, while chronic tension‐vascular headache may have a depressive substrate. Four‐channel sleep recording may miss contributory sleep apnea, but nonetheless cassette EEG may facilitate outpatient evaluation of refractory headaches.
Acetylsalicylic Acid vs. Metoprolol in Migraine Prophylaxis ‐ A Double‐Blind Cross‐Over Study
Authors: Grotemeyer K‐H , Scharafinski H‐W , Schlake H‐P , Husstedt IW 
Published: May 2005

SYNOPSISIn a double blind cross‐over study, 28 patients, 5 male and 23 female, aged 31 ± 14 years, after a run‐in period of 8 weeks, were treated for 3 months with acetylsalicylic acid and for another 3 months with metoprolol, both in a prophylactic mode. Attack frequency was reduced significantly with both therapeutic regimens (ASA p<0.001, metoprolol p<0.00005). Reduction of attacks below 50% was seen with metoprolol in 14 cases, and with ASA in three cases. Even though ASA was of statistically significant efficacy in migraine prophylaxis, it clearly is not the drug of first choice in migraine prophylaxis.
The Cluster Diathesis
Authors: Gawel M.J. , Krajewski A. , Luo Y.M. , Ichise M. 
Published: May 2005

SYNOPSISWe present further evidence for a sympathetic defect of vasomotor control of the anterior cerebral artery (ACA) on the side of the headache during cluster periods. In 119 cluster headache patients, utilizing transcranial Doppler, we measured CO2 reactivity of the major intracranial vessels, in and out of cluster. Reactivity was significantly lower during the cluster period, but only in the ACA on the side of the headache. Nineteen patients followed sequentially for a full cycle (ie/both in and out of a cluster period) showed the same changes. In 3 out of 6 patients in an active cluster period, we describe a lesion on Gallium single‐photon emission computerized tomography (SPECT) in the region of the cavernous sinus which fades as the patient moves out of cluster. It is felt that this lesion may represent the cavernous sinus plexus lesion postulated as the central lesion in cluster, Changes in the sympathetic outflow at this point could explain the changes we have described in ACA CO2 reactivity during cluster.
Cluster Headache: The Effect of Low Oxygen Saturation
Authors: Zhao JM , Schaanning J , Sjaastad O 
Published: May 2005

SYNOPSISThe present study concerns the possible relationship between hypoxia and the generation of cluster headache attacks. Fifteen controls and 25 cluster headache patients were studied. The patients were allocated into two groups according to cluster headache stage, i.e. cluster or remission period. During the tests, all the subjects were asked to inhale 12% oxygen (88% N2) for 30 min, and the decreasing oxygen saturation (SaO2 %) was monitored. Patients in the remission period showed nearly the same decrement of SaO2% as controls. At the end of the test, patients in the bout showed significantly less reduction of SaO2% than the controls. In 5 patients, the test was carried out both in and outside the cluster periods. The tendency to less decrement in oxygen saturation in the cluster phase was as marked with this comparison, but the difference between the groups was not significant, probably partly due to the low number of tests carried out. Only one patient got a typical attack. it seems that hypoxia of this magnitude per se is not the cause of attacks. The different pattern with respect to SaO2% following 12% O2 inhalation in cluster headache may be due to an abnormality in central regulation and/or chemoreceptor sensitivity.
Recurrent Tension Headache in Adolescents Treated with Self‐Help Relaxation Training and a Muscle Relaxant Drug
Authors: Larsson Bo , Melin Lennart , Döberl Anton 
Published: May 2005

SYNOPSISForty‐eight adolescents suffering from recurrent tension headache participated in a controlled trial conducted in a high school setting. During the first treatment phase self‐help relaxation training was compared with a waiting‐list group. Following this phase a pharmacological regimen consisting of a muscle relaxant (chlormezanone) and placebo was superimposed on relaxation therapy in a double‐blind crossover design. Each treatment phase encompassed a 5‐week period. In addition to the evaluation of headache complaints, psychological distress among students was measured with respect to their experience of somatic complaints, depressive, anxiety and stress symptoms. Although self‐help relaxation training significantly decreased the severity and annoyance of adolescents' headache besides their somatic complaints, the clinical improvement of headache was modest. The addition of chlormezanone did not help those who were nonresponders to self‐help relaxation training. Finally, a set of pretreatment variables consisting of baseline headache severity and annoyance, experience of anxiety and daily life stress among adolescents could predict outcome of self‐help relaxation therapy.
Headaches in Dementia
Authors: Takeshima Takao , Taniguchi Reiko , Kitagawa Tatsuya , Takahashi Kazuro 
Published: May 2005

SYNOPSISWe investigated 288 elderly subjects with various degree of dementia, focusing on headaches. Seventy‐three of 288 elderly subjects (25.3%) complained of some headaches. The most common type was the tension‐type headache, from which 43 of the 73 subjects with headaches (58.9%) suffered. The degree of cognitive disturbances, evaluated by Hasegawa's intelligence scale, significantly correlated to the prevalence of headaches, and indicated that patients with dementia appeared to have less headaches. The methodological issues and views on headache research in dementia were assessed, and it is concluded that the field is a difficult one, with potential for error.
Headaches Due to Spontaneous Internal Carotid Artery Dissection Magnetic Resonance Imaging Evaluation and Follow Up
Authors: Cox Linda K. , Bertorini Tulio , Laster Robert E. 
Published: May 2005

SYNOPSISSpontaneous internal carotid artery (ICA) dissection is not an infrequent cause of headache and acute neurologic deficits in the younger population. Angiography has been the imaging modality of choice for both diagnosis and follow‐up. The use of magnetic resonance imaging, (MRI), in conjunction with angiography, is described in three patients shown to have ICA dissection. Our clinical findings suggest that MRI may provide a less expensive, non‐invasive, diagnostic and particularly a follow up modality in patients with headache and signs suggestive of ICA dissection.
The Relationship of Cocaine to Headache in Polysubstance Abusers
Authors: Dhopesh Vasant , Maany Iradj , Herring Christina 
Published: May 2005

SYNOPSISIn a questionnaire survey of inpatient polysubstance abusers it was found that cocaine relieved migraine‐type headaches much more often in chronic headache sufferers than in those with only occasional headaches (p < .05). However, cocaine could also bring on headaches after several hours, both in chronic headache sufferers and in those not subject to headaches. The fasts that cocaine may relieve headache immediately, and also may precipitate headaches several hours after use, suggests that the well‐known vasoconstrictive actions of cocaine may be responsible. Migraineurs seem more susceptible to some of these effects of cocaine than are people without chronic headaches.
"Hemicrania Continua": A Clinical Review
Authors: Bordini Carlos , Antonaci Fabio , Stovner Lars Jacob , Schrader Harald , Sjaastad Ottar 
Published: May 2005

SYNOPSISHemicrania continua (HC) is a headache entity completely responsive to indomethacin. Since 1984, 18 cases have been described, 15 females and 3 males, i.e. a F:M ratio of 5.0. The finding of a female preponderance, like that in chronic paroxysmal hemicrania, is a new observation. HC is, in general, a unilateral headache in the sense that it sets in on one side and subsequently sticks to this side. In two case, both sides might possibly be involved, when the pain was at its maximum. In another (somewhat dubious) case the headache was bilateral. The pain was continuous from the beginning in 8 of 18 cases (early stage ratio continuous: non‐continuous = 0.8). Over time, the headache developed a continuous character in 16 of the 18 cases, producing a "continuous: non‐continuous ratio" of 8:1. The intensity of pain generally was moderate and was not reported as excruciatingly severe by any patient. The autonomic involvement from a clinical point of view, was clearly less pronounced than that of other unilateral headaches, such as cluster headache and chronic paroxysmal hemicrania.
Valproate in the Treatment of Persistent Chronic Daily Headache. An Open Label Study
Authors: Mathew Ninan T. , Ali Sabiha 
Published: May 2005

SYNOPSISThirty patients with persistent chronic daily headache, unresponsive to various combinations ofpharmacological and non‐pharmacological treatment were selected for an open label study using divalproex sodium. All patients had normal liver function tests. After a baseline observation period of 1month, patients were given divalproex sodium 1000 to 2000 mg per day, for a period of 3 months. Blood valproic acid levels were kept between 75 and 100 mcg/ml. Liver function studies and blood ammonia levels were obtained periodically. Based on weekly headache index, headache‐free days, dysfunctional days and patients' general well‐being rating and physicians' global assessment, two thirds of the patients improved significantly. The common side effects included weight gain, tremor, hair loss and nausea. Liver functions were unaffected by treatment.The possible mechanism of action of valproate in headache is discussed. Valproate appears to be aworthwhile addition to the prophylactic treatment of chronic recurrent headache.
The Differential Effects of Biofeedback in the Treatment of Menstrual and Nonmenstrual Migraine
Authors: Gauthier Janel G. , Fournier Anne‐Louise , Roberge Claude 
Published: May 2005

SYNOPSISThe aim of the present study was to investigate the effects of biofeedback training in the treatment of menstrual and non‐menstrual migraine. Accordingly, 39 female patients suffering from both migraine associated, and migraine not associated, with menstrual periods were drawn from a pool of research volunteers enrolled in a biofeedback treatment program for migraine headaches. All patients were required to complete 5 weeks of daily self‐monitoring of headache and menstruation activity immediately before and after treatment, and again at 6‐month follow‐up. Within‐subjects comparisons of the effects of biofeedback on menstrual and nonmenstrual migraine, and between‐subjects comparisons of the effects of biofeedback on patients suffering predominantly from either menstrual or nonmenstrual migraine showed that biofeedback is just as effective in reducing menstrual migraine as it is in reducing nonmenstrual migraine. Questions as to whether or not these conclusions can apply to patients who experience migraine headaches only during, or shortly before or after, menstruation, are raised.
Headache Spectrum in Arnold‐Chiari Malformation
Authors: Khurana Ramesh K. 
Published: May 2005

SYNOPSISExertional headaches in patients with Arnold‐Chiari malformation (ACM) are well described. Were port four patients with Type I ACM and recurrent headaches. These patients presented, respectively, with low spinal fluid pressure headache, migraine without aura, migraine with aura, and migraine with prolonged aura. This report suggests the need for observing patients with recurrent headaches for any physical stigmata of craniovertebral junction anomalies, and the need to exclude ACM in such patients. Possible implications of the association between ACM and different types of headaches are discussed.
Headache in the Use and Withdrawal of Opiates and Other Associated Substances of Abuse
Authors: De Marinis M. , Janiri L. , Agnoli A. 
Published: May 2005

SYNOPSISThe incidence and character of headache were retrospectively studied in 40 opiate addicts and 40 control subjects. The relationships between headache and use and withdrawal of opiates or other associated substances of abuse were investigated. In the opiate‐dependent patients, the effects of opiate intake and withdrawal on headache were also investigated during detoxification treatment. A higher (p<0.001) incidence of headache was found in the opiate addicts (60%), particularly those with a longer history of addiction, than in the control subjects. A history of different types of headache (tension type headache, migraine‐like headaches), which seemed respectively to be associated with the use of certain types of heroin, cocaine intake, and opiate withdrawal, was reported by the addicts who suffered from headache. Out of the 24 patients who completed the detoxification therapy, a migraine‐like headache occurred in 37.5% of the subjects after opiate withdrawal.
Subcutaneous Sumatriptan in the Treatment of Headache During Withdrawal From Drug‐Induced Headache
Authors: Diener H.C. , Haab J. , Peters C. , Ried S. , Dichgans J. , Pilgrim A. 
Published: May 2005

SYNOPSISIn a pilot study (5 patients) we investigated the effects of subcutaneous sumatriptan, a 5‐HT1‐like receptoragonist, on headache experienced during the withdrawal period of drug‐induced headache. The pilot studyindicated that the substance was effective mostly in patients who originally suffered from migraine. In a patientwith tension headache the substance was less effective. In a second double‐blind study on six migraine patientswith severe drug‐induced headache, the drug was highly effective in ameliorating headache and autonomicdisturbances. Blood flow velocities measured in extracranial parts of internal and external carotid arteries byduplex‐sonography and in middle cerebral and basilar arteries by transcranial Doppler showed no changes afteradministration of sumatriptan or placebo. This result suggests sumatriptan does not act primarily via constrictionof the large cerebral arteries.
Chronic Cluster Headache Associated With a Vertebral Artery Aneurysm
Authors: West Paul , Todman Don 
Published: May 2005

SYNOPSISThis is a report of a patient with chronic cluster headache‐like pain of 12 years duration. Investigation revealed an aneurysm at the junction of the vertebral and posterior inferior cerebellar arteries and after removal the patient experienced resolution of his cluster headache. The headache and aneurysm were both right sided suggesting a possible relationship.
5‐Hydroxtryptamine 1D Receptor Agonism Predicts Antimigraine Efficacy
Authors: Anastasia V. , Deliganis B.S. , Peroutka Stephen J. 
Published: May 2005

SYNOPSISThe interactions of four abortive anti‐migraine agents and four prophylactic anti‐migraine agents with 5‐HT1D receptors in bovine brain were analyzed using radioligand binding techniques and adenylate cyclase assays. In bovine caudate, the affinities of abortive anti‐migraine agents (i.e. 5‐hydroxytryp‐tamine, ergotamine, dihydroergotamine, sumatriptan) for 5‐HT1D receptors range from 4.0 – 34 nM while the affinities of prophylactic anti‐migraine agents (i.e. methysergide, amitriptyline, (‐)propranolol, verapamil) range from 46 – 11,000 nM. In adenylate cyclase studies in bovine substantia nigra, all four abortive anti‐migraine agents dose‐dependently inhibit forskolin‐stimulated adenylate cyclase activity, a biochemical effect mediated by 5‐HT1D receptors. No agonist effect on cyclase activity is observed with the four prophylactic anti‐migraine agents. These date support the hypothesis that abortive anti‐migraine agents are 5‐HT1D receptor agonists and that this effect may underlie their anti‐migraine efficacy.
EEG and Topographic Frequency Analysis in Common and Classic Migraine
Authors: Neufeld M.Y. , Treves T.A. , Korczyn A.D. 
Published: May 2005

SYNOPSISElectroencephalographic (EEG) changes occurring in patients with migraine have received much attention. However, almost equal number of reports indicate the predominance of normal and abnormal findings. We studied the EEG in symptom‐free, otherwise healthy, unmedicated 18–28 year‐old patients: 22 with common migraine, 20 with classic migraine, and 20 age‐matched controls. The routine EEG findings in the three groups revealed mild non‐specific slowing in 2 (9%), 3 (15%) and 2 (10%), respectively. Simultaneously, topographic EEG mapping and frequency analysis were performed in 13 consecutive patients with common migraine, 10 patients with classic migraine and 11 age‐matched controls. EEG mapping showed minimal regional differences with lower power in the alpha range in patients with eyes closed. The peak alpha power, as well as its reactivity, were lower among patients than controls. This difference reached statistical significance only for patients with classic migraine versus controls in the left occipital region. Patients also had slightly faster peak alpha frequency. No frank right‐left asymmetry was observed in the peak alpha power, neither among the controls, nor the patients. All the findings were rather minor. They may suggest some difference in the posterior background activity in the EEG in migraine patients as compared to the controls, but are not useful in differentiating migraine from non‐migraine patients.
Reading Problems In Adult Chronic Headache Sufferers
Authors: Cremins James J. , Spierings Egilius L.H. , Meltzer Lynn J. , Messinger Harley B. , Lebbink John 
Published: May 2005

SYNOPSISIn a questionnaire survey we determined the prevalence of problems with reading, at present as well as in the past, in adult chronic headache sufferers as compared with age‐ and sex‐matched controls. The reading problems inquired about were those with reading in general, reading quickly, prolonged reading and reading comprehension. The subjects were also asked about present and past problems with writing, concentrating, performing mathematics and overall learning.Significant difference in the prevalences of the problems studied between the headache sufferers and controls were observed on just two items and only for the female groups. These items were present problems with reading comprehension (39.3% versus 7.5%; p=0.002) and concentrating (46.4% versus 17.5%; p=0.015). We concluded that adult female headache sufferers have impaired reading comprehension and concentration abilities which do not seem to originate from the past.
Questionnaire Versus Clinical Interview in the Diagnosis of Headache
Authors: Rasmussen Birthe Krogh , Jensen Rigmor , Olesen Jes 
Published: May 2005

SYNOPSISA self‐administered questionnaire based on the operational diagnostic criteria of the International Headache Society (IHS) was evaluated in a cross‐sectional epidemiological survey of headache disorders. A clinical interview was used as index of validity. Seven hundred and thirteen subjects were included.Sensitivity, specificity, predictive value, and chance‐corrected agreement rate for the diagnosis of migraine was 51%, 92%, 50% (PVpos), 93% (PVneg), and 0.43 respectively. Corresponding values for episodic tension‐type headache were 43%, 96%, 95% (PVpos), 46% (PVneg), and 0.30; and for chronic tension‐type headache 14%, 100%, 100% (PVpos), 97% (PVneg), and 0.24. It is concluded that a questionnaire is not a satisfactory tool in diagnosing headache disorders according to the IHS criteria.The methods of data collection seem to have significant influence on the results. Caution in handling data obtained by means of subjective statements is advocated.