bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction and validation of a nomogram for predicting the prognosis of patients with lymph node-positive invasive micropapillary carcinoma of the breast: based on SEER database and external validation cohort
Authors: Li Yifei , Liu Jinzhao , Xu Zihang , Shang Jiuyan , Wu Si , Zhang Meng , Liu Yueping 
Published: October 2023

BackgroundInvasive micropapillary carcinoma (IMPC) of the breast is a rare subtype of breast cancer with high incidence of aggressive clinical behavior, lymph node metastasis (LNM) and poor prognosis. In the present study, using the Surveillance, Epidemiology, and End Results (SEER) database, we analyzed the clinicopathological characteristics and prognostic factors of IMPC with LNM, and constructed a prognostic nomogram.MethodsWe retrospectively analyzed data for 487 breast IMPC patients with LNM in the SEER database from January 2010 to December 2015, and randomly divided these patients into a training cohort (70%) and an internal validation cohort (30%) for the construction and internal validation of the nomogram, respectively. In addition, 248 patients diagnosed with IMPC and LNM at the Fourth Hospital of Hebei Medical University from January 2010 to December 2019 were collected as an external validation cohort. Lasso regression, along with Cox regression, was used to screen risk factors. Further more, the discrimination, calibration, and clinical utility of the nomogram were assessed based on the consistency index (C-index), time-dependent receiver operating characteristic (ROC), calibration curve, and decision curve analysis (DCA).ResultsIn summary, we identified six variables including molecular subtype of breast cancer, first malignant primary indicator, tumor grade, AJCC stage, radiotherapy and chemotherapy were independent prognostic factors in predicting the prognosis of IMPC patients with LNM (P &lt; 0.05). Based on these factors, a nomogram was constructed for predicting 3- and 5-year overall survival (OS) of patients. The nomogram achieved a C-index of 0.789 (95%CI: 0.759-0.819) in the training cohort, 0.775 (95%CI: 0.731-0.819) in the internal validation cohort, and 0.788 (95%CI: 0.756-0.820) in the external validation cohort. According to the calculated patient risk score, the patients were divided into a high-risk group and a low-risk group, which showed a significant difference in the survival prognosis of the two groups (P&lt;0.0001). The time-dependent ROC curves, calibration curves and DCA curves proved the superiority of the nomogram.ConclusionsWe have successfully constructed a nomogram that could predict 3- and 5-year OS of IMPC patients with LNM and may assist clinicians in decision-making and personalized treatment planning.
Management and clinical outcomes of follicular lymphoma across continuous lines of treatments: a retrospective analysis in China
Authors: Liu Jiaxin , Hu Yunfei , Zhao Linjun , Nuersulitan Reyizha , Liu Yanfei , Yu Hui , Ye Yingying , Wang Dedao , Tang Yongjing , Feng Feier , Liu Weiping , Zhu Jun , Ping Lingyan , Song Yuqin 
Published: October 2023

BackgroundFollicular lymphoma (FL) is characterized by an incurable course that frequently necessitates multiple lines of treatment. While a range of new approaches have broadened therapeutic options for patients in later lines, data regarding treatment patterns and outcomes of Chinese patients with relapsed/refractory(R/R) FL was scarcely reported.MethodsThis retrospective single-center study included patients diagnosed with FL grades 1–3a at our institution between January 2002 and December 2019. Endpoints of interest were analyzed according to lines and types of interventions. The endpoints mainly included overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).ResultsThe study enrolled 566 biopsy-proven patients. Among them, 544 patients initiated the first line of treatment, followed by 240 initiating the second line, 146 initiating the third line, 88 initiating the fourth line, 47 initiating the fifth line, and 28 initiating the sixth line. In terms of treatment patterns, anti-CD20 chemotherapy was a major modality in the first and second lines. However, for patients in the third line and subsequent lines, treatment approaches were diverse, and participation in clinical trials for new medications was common, which correlated with a survival benefit. The study also revealed that clinical indicators (such as ORR, PFS, and OS) gradually decreased with each subsequent line of treatment. The ORR at the first line was 86.6%, but decreased to 48.6% at the third line and 40.4% at the sixth line, respectively. Similarly, median OS and PFS decreased to 88.8 and 7.1 months at the third line and further reduced to 21.7 and 2.8 months at the sixth line, respectively. A total of 133 patients developed progression within 24 months from the initiation of first line anti-CD20 chemotherapy (POD24), and these patients exhibited poorer response rates and outcomes in subsequent lines of therapycompared to the non-POD24 group.ConclusionThis study revealed the clinical routine practices and prognosis of R/R FL patients within the Chinese population. It underscored the unmet need for optimal strategies to improve survival and also served as a benchmark for future trials.
Cohort differences in attitudes toward sexual orientation: the formative political climate as a socializing agent
Authors: Jeannet Anne-Marie , Dražanová Lenka 
Published: October 2023

IntroductionWhy do cohorts differ in their attitudes toward sexual orientation and what is the role of societal values during formative years? We investigate whether discontinuities in the prevailing values of equality and tradition in a person's formative years impinge on their attitudes toward sexual orientation as adults.MethodsWe test this by integrating historical political data from the Manifesto Project Dataset with contemporary micro-data on attitudes toward sexual orientation from 10 rounds of the European Social Survey (2002-2020) across 13 cohorts in 13 European countries.Results and discussionUsing hierarchical age-period-cohort analysis with synthetic age cohorts, we find if the value of equality is politically diffuse, it can have a socializing effect. We find that the individuals who came of age during a period when political values of equality were more dominant are more tolerant of gays and lesbians. On the other hand, we do not find any evidence that individuals who experience youth during a time of more traditional political values have more negative opinions about different sexual orientations. Overall, these findings suggest that cohorts adopt distinct patterns of attitudes toward gays and lesbians as a result of a collective process of socialization during their impressionable years.
Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China
Authors: Zeng Jingke , Lai Xiaohuan , Wang Shuigen , Zeng Dijing , Ye Jiangmin , Huang Chunhua , Liu Minhua , Zhang Wenjuan , Xu Hui 
Published: October 2023

BackgroundThe relationship between depressive symptoms and chronic liver disease (CLD) is still unclear. We aimed to determine whether depressive symptoms are associated with CLD in a large population sample.MethodsThe data was from the China Health and Retirement Longitudinal Study (CHARLS), an ongoing nationally representative prospective cohort study. Depressive symptoms were assessed with the catchment-area epidemiology survey-depression (CES-D). CLD was identified by the patient’s self-report about a physician’s diagnosis at each visit. Multi-adjusted logistic regression and Cox regression models were used.ResultsA total of 14,995 participants (53.1% female; mean age: 58.85 ± 9.87 years) and 13,405 participants (53.64% female; mean age: 58.58 ± 9.69 years) were included in the cross-sectional and longitudinal analyses, respectively. In the cross-sectional analysis, the odds ratio of CLD in patients with moderate and severe depressive symptoms were 1.46 [95% confidence interval (CI), 1.16–1.83] and 1.78 (95% CI, 1.23–2.56) than those with none/mild depressive symptoms, respectively. In the longitudinal analysis, compared to participants with none/mild depressive symptoms, the hazard rates of CLD in those with moderate and severe depressive symptoms were 1.65 (95%CI, 1.33–2.03) and 1.80 (95%CI, 1.24–2.60). And the 50th percentile difference of time (years) at the incidence of CLD in participants with moderate and severe depressive symptoms were − 0.83 (95%CI, −1.18, −0.49) and − 0.96 (95%CI, −1.56, −0.35), respectively.ConclusionElevated depressive symptoms were associated with an increased risk of CLD among middle-aged and older adults in China.
Biological correlates of treatment resistant depression: a review of peripheral biomarkers
Authors: Mancuso Emiliana , Sampogna Gaia , Boiano Alessia , Della Rocca Bianca , Di Vincenzo Matteo , Lapadula Maria Vita , Martinelli Flavia , Lucci Federico , Luciano Mario 
Published: October 2023

IntroductionMany patients fail to respond to multiple antidepressant interventions, being defined as “treatment-resistant depression” (TRD) patients. TRD is usually associated with increased severity and chronicity of symptoms, increased risk of comorbidity, and higher suicide rates, which make the clinical management challenging. Efforts to distinguish between TRD patients and those who will respond to treatment have been unfruitful so far. Several studies have tried to identify the biological, psychopathological, and psychosocial correlates of depression, with particular attention to the inflammatory system. In this paper we aim to review available studies assessing the full range of biomarkers in TRD patients in order to reshape TRD definition and improve its diagnosis, treatment, and prognosis.MethodsWe searched the most relevant medical databases and included studies reporting original data on possible biomarkers of TRD. The keywords “treatment resistant depression” or “TRD” matched with “biomarker,” “inflammation,” “hormone,” “cytokine” or “biological marker” were entered in PubMed, ISI Web of Knowledge and SCOPUS databases. Articles were included if they included a comparison with healthy controls (HC).ResultsOf the 1878 papers identified, 35 were included in the present study. Higher plasma levels of IL-6 and TNF-α were detected in TRD patients compared to HC. While only a few studies on cortisol have been found, four papers showed elevated levels of C-reactive protein among these patients and four articles focused on immunological cells. Altered kynurenine metabolism in TRD patients was reported in two studies, while contrasting results were found with regard to BDNF.ConclusionOnly a few biological alterations correlate with TRD. TNF-α seems to be the most relevant biomarker to discriminate TRD patients from both HC and treatment-responsive MDD patients. Moreover, several discrepancies among studies have been found, due to methodological differences and the lack of a standardized diagnostic definition of TRD.
The effect of urban–rural health insurance integration on consumption of middle-aged and older adult households in rural areas: evidence from China
Authors: Wang Lianjie , Hu Qi 
Published: October 2023

IntroductionRural consumption is crucial in promoting economic and social development in China’s economic slowdown. Integrating urban-rural residents’ health insurance has alleviated the financial burden of medical expenses for rural households and boosted rural household consumption. This study examines the effect of integrating urban–rural residents’ health insurance on the consumption patterns of middle-aged and older adult households in rural China. Our research provides a reference basis for improving rural healthcare security and enhancing the sustainable consumption capacity in rural areas.MethodsWe employed a Propensity Score Matching Difference-in-Differences model (PSM-DID) to estimate the association between health insurance integration and household consumption using panel data from the China Health and Retirement Longitudinal Study (CHARLS) from 2013 to 2018. Furthermore, we employed a mediation model to analyze the influencing mechanisms.ResultsOur findings suggested a positive association between health insurance integration and survival consumption as well as total consumption among rural middle-aged and older adult households. The conclusion remained valid after endogeneity treatment, robustness and placebo tests. Furthermore, we found that the impact of health insurance integration is more pronounced for middle-aged, female, and high-income rural residents’ households. Integrating urban–rural residents’ health insurance raised consumption by reducing medical expenses and increasing health and life expectancy.DiscussionPolicymakers should deepen the rural medical and health system reform, improve the convenience of medical services for middle-aged and older adult families in rural areas, and improve the medical and life assistance mechanism for vulnerable groups in rural areas. Additionally, the local government should continuously broaden rural household income channels to promote upgrading consumption structure while improving overall consumption levels.
Heart rate responses, agreement and accuracy among persons with severe disabilities participating in the indirect movement program: Team Twin—an observational study
Authors: Jørgensen Andreas , Toftager Mette , Eghøj Martin , Ried-Larsen Mathias , Bjørk Petersen Christina 
Published: October 2023

IntroductionHeart rate (HR) monitors are rarely used by people living with disabilities (PLWD), and their accuracy is undocumented. Thus, this study aims to describe the HR response during the Team Twin co-running program and, secondly, to assess the agreement and accuracy of using HR monitors among PLWD.MethodsThis 16-week single-arm observational study included 18 people with various disabilities. During the study, the subjects wore a Garmin Vivosmart 4 watch (wrist). To evaluate the agreement and accuracy we applied Garmin’s HRM-DUAL™ chest-worn HR monitors for comparison with the Vivosmart 4. The HR response analysis was performed descriptively and with a mixed regression model. The HR agreement and accuracy procedure was conducted on a subsample of five subjects and analyzed using Lin’s concordance analysis, Bland and Altman’s limits of agreement, and Cohen’s kappa analysis of intensity zone agreement. This study was prospectively registered at Clinical Trials.gov (NCT04536779).ResultsThe subjects had a mean age of 35 (±12.6), 61% were male, 72% had cerebral palsy were 85% had GMFCS V-IV. HR was monitored for 202:10:33 (HH:MM:SS), with a mean HR of 90 ± 17 bpm during training and race. A total of 19% of the time was spent in intensity zones between light and moderate (30%–59% HR reserve) and 1% in vigorous (60%–84% HR reserve). The remaining 80% were in the very light intensity zone (&lt;29% HR reserve). HR was highest at the start of race and training and steadily decreased. Inter-rater agreement was high (k = 0.75), limits of agreement were between −16 and 13 bpm, and accuracy was acceptable (Rc = 0.86).ConclusionDisability type, individual, and contextual factors will likely affect HR responses and the agreement and accuracy for PLWD. The Vivosmart 4, while overall accurate, had low precision due to high variability in the estimation. These findings implicate the methodical and practical difficulties of utilizing HR monitors to measure HR and thus physical activity in adapted sports activities for severely disabled individuals.
Spread of Pseudomonas aeruginosa ST274 Clone in Different Niches: Resistome, Virulome, and Phylogenetic Relationship
Authors: Chichón Gabriela , López María , de Toro María , Ruiz-Roldán Lidia , Rojo-Bezares Beatriz , Sáenz Yolanda 
Published: October 2023

Pseudomonas aeruginosa ST274 is an international epidemic high-risk clone, mostly associated with hospital settings and appears to colonize cystic fibrosis (CF) patients worldwide. To understand the relevant mechanisms for its success, the biological and genomic characteristics of 11 ST274-P. aeruginosa strains from clinical and non-clinical origins were analyzed. The extensively drug-resistant (XDR/DTR), the non-susceptible to at least one agent (modR), and the lasR-truncated (by ISPsp7) strains showed a chronic infection phenotype characterized by loss of serotype-specific antigenicity and low motility. Furthermore, the XDR/DTR and modR strains presented low pigment production and biofilm formation, which were very high in the lasR-truncated strain. Their whole genome sequences were compared with other 14 ST274-P. aeruginosa genomes available in the NCBI database, and certain associations have been primarily detected: blaOXA-486 and blaPDC-24 genes, serotype O:3, exoS+/exoU− genotype, group V of type IV pili, and pyoverdine locus class II. Other general molecular markers highlight the absence of vqsM and pldA/tleS genes and the presence of the same mutational pattern in genes involving two-component sensor-regulator systems PmrAB and CreBD, exotoxin A, quorum-sensing RhlI, beta-lactamase expression regulator AmpD, PBP1A, or FusA2 elongation factor G. The proportionated ST274-P. aeruginosa results could serve as the basis for more specific studies focused on better antibiotic stewardship and new therapeutic developments.
The negative impact factor analysis to the environment from logging production on the North-West region of Russian Federation
Authors: Grafova Elena , Syunev Vladimir , Gorbach Vyacheslav 
Published: October 2023

Logging operations and timber transportation have a negative impact to natural and natural-anthropogenic
environmental objects. Accounting, evaluation and forecasting of negative impact types will allow rational planning of
technological logging operations. The negative impact degree data will allow assessing the total damage to
environmental objects and, taking into account the loads of a particular work types provide for a set of protective
measures adequate to the corresponding impact degree. The impact degree of types of logging activities to the
environment was determined using the method of expert assessments. The variability of the nature and significance of
the technogenic impact from logging and removal of wood was studied by the method of principal components. The
generalized list of types of negative impact is ranked in the direction of decreasing degree as follows: pollution of water
runoff and soils by leaks of fuels and lubricants, changes in biodiversity, damage to forest stands, destruction and
pollution of soils, air pollution with chemical impurities, wastewater discharges into water bodies, landfill of domestic
waste and discharge of effluents into the soil. When assessing biodiversity, increased attention should be paid to the
organization of household and auxiliary technological processes. They are characterized by medium loads, causing
pollution of water and soil by domestic and industrial effluents, and the formation of landfills for domestic and
industrial waste. The construction of forest roads and work on refueling, repair and maintenance of logging equipment
in workshops and fuel filling stations contribute to the manifestation of atypical impacts in the form of water and soil
pollution with oil products. The obtained theoretical substantiation must be supplemented with relevant data from field
studies on the identified types of negative impacts. Based on the predicted values of the degree of negative impact on
the environment, the authors develop a set of scientifically substantiated technical and technological solutions that
increase environmental safety during logging operations
Plasmonic red-light-emission enhancement by honeycomb-latticed InGaN/GaN ordered fine nanocolumn arrays
Authors: Oto Takao , Aihara Aoto , Motoyama Kai , Ishizawa Shunsuke , Okamoto Koichi , Togashi Rie , Kishino Katsumi 
Published: October 2023

Abstract
By using ordered fine nanocolumns suitable for high-efficiency red-emission, emission enhancement based on surface plasmon polariton (SPP) coupling was successfully obtained for the honeycomb lattice. This lattice enables us to obtain a longer SPP resonant wavelength in the red region, which could not be attained for the triangular lattice. A 4.8-fold red-emission enhancement was achieved for the honeycomb lattice, demonstrating effective synergy between plasmonic and nanocrystalline effects within the red-emission nanocolumn system. Additionally, a 3.2-fold light-extraction enhancement was attained by changing the emission directionality by introducing plasmonic crystals (PlCs) in addition to metal reflection.
Pengembangan Bahan Ajar Pai Berbasis Problem Based Learning Untuk ‎Meningkatkan Kemampuan Berpikir Kritis Siswa
Authors: Al Hadiq Afiffudin 
Published: October 2023

Dalam meningkatkan nalar berfiir kritis siswa pembelajaran berdasarkan Problem Based Learning (PBL) ini sangat efektif sekali dengan pembuatan bahan ajar berupa Lembar Kerja Siswa (LKS) lebih afektif dan berdampak pada siswa, dengam materi PAI siswa mampu nganalisis dan mapu menyelesaiakan masalah maslah yang di berikan. perangkat pembelajaran yang dikembangkan ini sangat mudah digunakanoleh siswa dalam proses pembelajaran dan juga dapat mengatasikesulitan belajar siswa (learning obstacle) dalam hal ini dapat meningkat kan siswa dapat berfikir kritis. Metode penelitian ini pada dasarnya adalah metode literature review. Metode pengumpulan data dalam penelitian ini adalah dengan menggunakan studi kepustakaan sedangkan studi literatur adalah pengumpulan buku-buku yang berkaitan dengan penelitian. Sumber informasi ini bisa dari buku, maupun jurnal ilmiah
Japanese poetry “Senryu” as a reflection of culture and lifestyle of Japan
Authors: Мията М. 
Published: October 2023

В статье исследуется отражение культуры и стиля жизни Японии в юмористической поэзии сэнрю на протяжении существования этого жанра, то есть с начала XVII века. Для достижения цели автор описывает историю японской поэзии до образования жанра сэнрю и ситуацию с конкурсами сэнрю в Японии в наши дни, определяет понятие юмора в жанре и анализирует стихи сэнрю, занявшие высокие места на конкурсе The Salaryman Senryu Contest в 2020 и 2021 годах и отражающие жизнь во время пандемии COVID-19. Исследование показывает, что современные стихотворения сэнрю, получившие призовые места, охватывают темы, которые касаются большого количества людей в Японии, такие как удаленная работа, ношение маски и трудности в общении, вызванные этими обстоятельствами. Таким образом, можно сказать, что темы, упоминаемые в стихотворениях сэнрю, актуальны и отражают культуру и образ жизни японцев.The article explores the reflection of culture and lifestyle of Japan in humorous poetry “senryu”. To achieve the aim, the author outlines the history of Japanese poetry till the formation of the genre “senryu” and the situation with the “senryu” contests in Japan nowadays, clarifies the definition of humour in “senryu”, and analyzes the award-winning “senryu” poems in The Salaryman Senryu Contest for 2020 and 2021, written about life during the COVID-19 pandemic. The study shows that award-winning “senryu” poems cover topics that a large number of people in Japan are related to, such as “remote work”, “face masks” and difficulty in communication caused by them. Thus, it can be said that the topics mentioned in “senryu” poems are relevant to and reflect the culture and lifestyle of the Japanese.