bluuebunny/crossref_metadata_2025_split huggingface dataset:
Out‐of‐Equilibrium Mechanical Disruption of β‐Amyloid‐Like Fibers using Light‐Driven Molecular Motors
Authors: Daou Dania , Zarate Yohan , Maaloum Mounir , Collin Dominique , Fleith Guillaume , Constantin Doru , Moulin Emilie , Giuseppone Nicolas 
Published: January 2024

AbstractArtificial molecular motors have the potential to generate mechanical work on their environment by producing autonomous unidirectional motions when supplied with a source of energy. However, the harnessing of this mechanical work to subsequently activate various endoenergetic processes that can be useful in materials science remains elusive. Here, it is shown that by integrating a light‐driven rotary motor through hydrogen bonds in a β‐amyloid‐like structure forming supramolecular hydrogels, the mechanical work generated during the constant rotation of the molecular machine under UV irradiation is sufficient to disrupt the β‐amyloid fibers and to trigger a gel‐to‐sol transition at macroscopic scale. This melting of the gel under UV irradiation occurs 25 °C below the temperature needed to melt it by solely using thermal activation. In the dark, a reversible sol–gel transition is observed as the system fully recovers its original microstructure, thus illustrating the possible access to new kinds of motorized materials that can be controlled by advanced out‐of‐equilibrium thermodynamics.
Origin, Metastasis, Harm, Recognition and Capture, and Elimination of Circulating Tumor Cells
Authors: Yuan Qianqian , Chen Lin , Wan Mimi , Mao Chun , Shen Jian 
Published: January 2024

AbstractCancer is now a major threat to human health and life. Although a number of clinical approaches to cancer treatment have been developed in recent years, tumor recurrence and metastasis remain a challenge. As the “seed” for the formation of tumor metastasis, Circulating Tumor Cells (CTCs) can not only grow and spread in the primary site, but also spread to other parts of the body through various ways. The close connection between CTCs and tumor progression makes them a focus of clinical and basic research attention, and it not only has an important guide for the clinical treatment of patients, but also a window into the occurrence and development of distant metastases. The identification and detection of CTCs have an important clinical significance in the assessment of the prognosis of cancer, efficacy prediction, efficacy evaluation, and the study of recurrent metastasis and drug resistance mechanisms of cancer patients. Therefore, this review not only introduces the source, attributes, transfer, and harm of CTCs, but also highlights the progress and latest technologies for the identification and capture and elimination strategies of CTCs and presents prospects for future research of CTCs.
B(I)‐Site Alkali Metal Engineering of Lead‐Free Perovskite Nanocrystals for Efficient X‐Ray Detection and Imaging
Authors: Wang Zhongyi , Chen Junsheng , Xu Xin , Bai Tianxin , Kong Qingkun , Yin Hong , Yang Yang , Yu William W. , Zhang Ruiling , Liu Xiaojing , Han Keli 
Published: January 2024

AbstractLead‐free metal halide double perovskites have emerged as promising scintillators owing to their superior optoelectronic properties, low‐cost and solution processability. However, it is still challenging to develop high‐performance flexible X‐ray scintillators based on the B(I)‐site alkali metal modulation in lead‐free double perovskite nanocrystals (NCs). Herein, a series of novel Cs2B(I)GdCl6 (B: Li, Na, K) of double perovskite A2B(I)M(III)X6 NCs structures are successfully synthesized, the optical and scintillator properties of which are significantly sensitive to the B(I)‐site alkali metals with the doping of Sb3+. They showed efficient self‐trapped exciton (STE) emission with high photoluminescence quantum yield (PLQY) and exhibited the highest X‐ray detection limit (86 nGyair s−1) and excellent spatial resolutions (>15 lp mm−1). The femtosecond transient absorption measurement and theoretical analysis further revealed that the B(I)‐site alkali metal fundamentally balanced the exciton–phonon coupling with appropriate STEs formation energy barrier and the electron localization and thus improved the optical and scintillator properties. This B(I)‐site alkali metal engineering offers a strategy to develop bright luminescent double perovskite NCs for X‐ray detection and imaging devices.
Synthesis of Styrenes and E‐Stilbenes by Palladium‐Catalyzed Vinylation of Aryl Iodides with 1,2‐Dibromoethane
Authors: Shi Guangfa , Ma Xiaotian , Zhu Qiongqiong , Zhang Yanghui 
Published: January 2024

AbstractThe Pd‐catalyzed vinylation reactions of aryl iodides using 1,2‐dibromoethane is developed for the synthesis of styrenes and stilbenes. In these reactions, vinyl bromide is generated from 1,2‐dibromoethane and then undergoes reductive cross‐coupling with aryl iodides, affording styrene products. Under slightly modified reaction conditions, styrenes can continue reacting with vinyl bromide to form E‐stilbenes, which provides a one‐pot synthetic method for stilbenes. Alcohols, including iso‐propanol and methanol, are employed as the reductant in these reductive cross‐coupling reactions.
Injectable Nano‐Micro Composites with Anti‐bacterial and Osteogenic Capabilities for Minimally Invasive Treatment of Osteomyelitis
Authors: Lu Guanghua , Zhao Gang , Wang Shen , Li Hanqing , Yu Qiang , Sun Qi , Wang Bo , Wei Li , Fu Zi , Zhao Zhenyu , Yang Linshan , Deng Lianfu , Zheng Xianyou , Cai Ming , Lu Min 
Published: January 2024

AbstractThe effective management of osteomyelitis remains extremely challenging due to the difficulty associated with treating bone defects, the high probability of recurrence, the requirement of secondary surgery or multiple surgeries, and the difficulty in eradicating infections caused by methicillin‐resistant Staphylococcus aureus (MRSA). Hence, smart biodegradable biomaterials that provide effective and precise local anti‐infection effects and can promote the repair of bone defects are actively being developed. Here, a novel nano‐micro composite is fabricated by combining calcium phosphate (CaP) nanosheets with drug‐loaded GelMA microspheres via microfluidic technology. The microspheres are covalently linked with vancomycin (Van) through an oligonucleotide (oligo) linker using an EDC/NHS carboxyl activator. Accordingly, a smart nano‐micro composite called “CaP@MS‐Oligo‐Van” is synthesized. The porous CaP@MS‐Oligo‐Van composites can target and capture bacteria. They can also release Van in response to the presence of bacterial micrococcal nuclease and Ca2+, exerting additional antibacterial effects and inhibiting the inflammatory response. Finally, the released CaP nanosheets can promote bone tissue repair. Overall, the findings show that a rapid, targeted drug release system based on CaP@MS‐Oligo‐Van can effectively target bone tissue infections. Hence, this agent holds potential in the clinical treatment of osteomyelitis caused by MRSA.
On‐Demand, Contact‐Less and Loss‐Less Droplet Manipulation via Contact Electrification
Authors: Wang Wei , Vahabi Hamed , Taassob Arsalan , Pillai Sreekiran , Kota Arun Kumar 
Published: January 2024

AbstractWhile there are many droplet manipulation techniques, all of them suffer from at least one of the following drawbacks – complex fabrication or complex equipment or liquid loss. In this work, a simple and portable technique is demonstrated that enables on‐demand, contact‐less and loss‐less manipulation of liquid droplets through a combination of contact electrification and slipperiness. In conjunction with numerical simulations, a quantitative analysis is presented to explain the onset of droplet motion. Utilizing the contact electrification technique, contact‐less and loss‐less manipulation of polar and non‐polar liquid droplets on different surface chemistries and geometries is demonstrated. It is envisioned that the technique can pave the way to simple, inexpensive, and portable lab on a chip and point of care devices.
Magnetodielectric Effect in a Triangular Dysprosium Single‐Molecule Toroics
Authors: Wang Yu‐Xia , Zhou Yicheng , Ma Yinina , Lu Peipei , Zhang Yi‐Quan , Sun Young , Cheng Peng 
Published: January 2024

AbstractSingle‐molecule toroics are molecular magnets with vortex distribution of magnetic moments. The coupling between magnetic and electric properties such as the magnetodielectric effect will provide potential applications for them. Herein, the observation of significant magnetodielectric effect in a triangular Dy3 crystal with toroidal magnetic moment and multiple magnetic relaxations is reported. The analysis of magnetic and electric properties implies that the magnetodielectric effect is closely related to the strong spin‐lattice coupling, magnetic interactions of Dy3+ ions, as well as molecular packing models.
Synthesis of Nb‐Doped‐WS2–NbS2: A Degenerate‐Semiconductor–Metal Heterostructure
Authors: Vu Van Tu , Nguyen Minh Chien , Kim Whan Kyun , Do Van Dam , Yu Woo Jong 
Published: January 2024

AbstractThe synthesis of semiconductor–metal (S–M) heterostructures comprising semiconducting (S)‐transition metal dichalcogenides (TMDs) and metallic (M)‐TMDs via chemical vapor deposition (CVD) has emerged as a highly promising avenue for achieving low contact resistance in TMD‐based devices. However, CVD‐grown S–M heterostructures are mainly focused on non‐degenerate semiconductors, despite degenerate semiconductors also being essential for semiconductor technology, such as negative differential resistance (NDR) device. In this study, a degenerate‐S–M heterostructure, Nb‐doped‐WS2–NbS2, is synthesized via CVD with a liquid‐metal precursor. Optimizing the growth parameters, such as growth temperature, precursor ratio, and H2 content in the mixture gas, affords the desirable degenerate‐Nb‐doped‐WS2–NbS2 heterostructure. Raman and photoluminescence spectroscopies, transmission electron microscopy, and energy‐dispersive spectroscopy clearly clarify the doping signal and layer structure of the heterostructure. A growth mechanism has been proposed using in‐plane and vertical models based on structural analysis. Electrical transport measurements reveal degenerate p‐type behavior in the Nb‐doped‐WS2. In the Nb‐doped‐WS2–NbS2 degenerate‐S–M heterostructure, the device flows about twice as much on‐state current as that by an Nb‐doped‐WS2/Cr contact.
SNNSim: Investigation and Optimization of Large‐Scale Analog Spiking Neural Networks Based on Flash Memory Devices
Authors: Ko Jonghyun , Kwon Dongseok , Hwang Joon , Lee Kyu‐Ho , Oh Seongbin , Kim Jeonghyun , Im Jiseong , Koo Ryun‐Han , Kim Jae‐Joon , Lee Jong‐Ho 
Published: January 2024

Spiking neural networks (SNNs) have emerged as a novel approach for reducing computational costs by mimicking the biologically plausible operations of neurons and synapses. In this article, large‐scale analog SNNs are investigated and optimized at the hardware‐level by using SNNSim, the novel simulator for SNNs that employ analog synaptic devices and integrate‐and‐fire (I&F) neuron circuits. SNNSim is a reconfigurable simulator that accurately and very quickly models the behavior of the user‐defined device characteristics and returns key metrics such as area, accuracy, latency, and power consumption as output. Notably, SNNSim exhibits exceptional efficiency, as it can process the entire 10 000 Modified National Institute of Standards and Technology (MNIST) test dataset in a few seconds, whereas SPICE simulations require hours to simulate a single MNIST test data. Using SNNSim, the conversion of artificial neural networks (ANNs) to SNNs is simulated and the performance of the large‐scale analog SNNs is optimized. The results enable the design of accurate, high‐speed, and low‐power operation of large‐scale SNNs. SNNSim code is now available at https://github.com/SMDLGITHUB/SNNSim.
Understanding chronic pain in Neurofibromatosis Type 1 using the Neurofibromatosis Pain Module (NFPM)
Authors: Buono Frank D. , Larkin Kaitlyn , Zempsky William T. , Grau Lauretta E. , Martin Staci 
Published: January 2024

AbstractNeurofibromatosis Type 1 (NF1) is an autosomal dominant genetic disorder that can cause an individual significant chronic pain (CP). CP affects quality of life and daily functioning, yet there are limited effective treatments for CP within NF1. The current study describes the impact of CP using the Neurofibromatosis Pain Module (NFPM). The NFPM is a self‐reported clinical assessment that evaluates the impact of CP across multiple domains (e.g., interference, severity, tolerance, and symptomology) and three prioritized pain regions. A cross‐sectional study (N = 242) asked adults with NF1 to describe and rate their pain using the NFPM. The results indicated that they reported moderate pain severity (M = 6.6, SD = 2.0) on a 0–10 scale, that 54% (n = 131) had been in pain at least 24 days in the last 30, for 75% (n = 181) sleep was affected, and 16% reported that nothing was effective in reducing their CP for their primary pain region. The current results extend previously published work on CP within adults with NF1 and indicate that more emphasis on understanding and ameliorating CP is required. The NFPM is a sensitive clinical measure that provides qualitative and quantitative responses to inform medical providers about changes in CP.
Iodine‐Catalyzed One‐pot Formation of Phosphorus‐Heteroatom Bonds from Stable Diphosphines in Air
Authors: Yamamoto Yuki , Fujiwara Kohsuke , Tanaka Ryo , Watanabe Hinako , Ogawa Akiya 
Published: January 2024

AbstractConventional methods for the synthesis of phosphorus‐centered interelement compounds have required air‐ and moisture‐sensitive phosphorus sources, which generate a lot of waste. Therefore, the catalytic and atom‐economical formation of phosphorus‐heteroatom linkages has been one of the challenging reactions. In this study, we found that the reaction of Ph2P(S)‐P(S)Ph2 and iodine could predominantly form Ph2P(S)‐I, which was quite stable to air and moisture and easy to handle. Subsequent one‐pot substitution reactions of Ph2P(S)‐I with nucleophiles (i. e., alcohols, amines, and thiols) led to various phosphorus‐heteroatom interelement compounds in moderate to excellent yields. In addition, catalytic formation of phosphorus‐heteroatom interelement compounds was successfully achieved by regeneration of the I2 catalyst via oxidation of HI (generated in situ) in air.
Senolysis Enabled by Senescent Cell‐Sensitive Bioorthogonal Tetrazine Ligation
Authors: Chang Mengyang , Dong Yue , Xu Hang , Cruickshank‐Taylor Alexis B. , Kozora Jacob S. , Behpour Baran , Wang Wei 
Published: January 2024

AbstractAlthough the clearance of senescent cells has been proven to slow down the aging process and promote anti‐cancer chemotherapy, the development of senolytics remains challenging. Herein, we report a senolytic strategy enabled by senescent cell‐sensitive bioorthogonal tetrazine ligation. Our design is based on linking dihydrotetrazine (Tz) to a galactose (Gal) moiety that serves both as a recognition moiety for senescence‐associated β‐galactosidase and a caging group for the control of tetrazine activity. Gal‐Tz enables efficient click‐release of a fluorescent hemicyanine and doxorubicin from a trans‐cyclooctene‐caged prodrug to detect and eliminate senescent HeLa and A549 cells over non‐senescent counterparts with a 16.44 senolytic index. Furthermore, we leverage the strategy for the selective activation and delivery of proteolysis‐targeting chimeras (PROTACs) as senolytics. PROTAC prodrug TCO‐ARV‐771 can be selectively activated by Gal‐Tz and delivered into senescent HeLa and A549 cells to induce the degradation of bromodomain‐containing protein 4. Senolytic PROTACs may offer an efficient way for intervention on cell senescence thanks to their unique capacity to degrade target proteins in a sub‐stoichiometric and catalytic fashion. The results of this study establish the bioorthogonal tetrazine ligation approach as a viable strategy for selective removal of senescent cells.
Overcoming a Radical Polarity Mismatch in Strain‐Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes: An Entryway to Sulfone‐ and Carbonyl‐Containing SF5‐Cyclobutanes
Authors: Kraemer Yannick , Buldt Jón Atiba , Kong Wang‐Yeuk , Stephens Alexander M. , Ragan Abbey N. , Park Soojun , Haidar Zane C. , Patel Ansh Hiten , Shey Rachel , Dagan Roee , McLoughlin Connor P. , Fettinger James C. , Tantillo Dean J. , Pitts Cody Ross 
Published: January 2024

AbstractThe first assortment of achiral pentafluorosulfanylated cyclobutanes (SF5‐CBs) are now synthetically accessible through strain‐release functionalization of [1.1.0]bicyclobutanes (BCBs) using SF5Cl. Methods for both chloropentafluorosulfanylation and hydropentafluorosulfanylation of sulfone‐based BCBs are detailed herein, as well as proof‐of‐concept that the logic extends to tetrafluoro(aryl)sulfanylation, tetrafluoro(trifluoromethyl)sulfanylation, and three‐component pentafluorosulfanylation reactions. The methods presented enable isolation of both syn and anti isomers of SF5‐CBs, but we also demonstrate that this innate selectivity can be overridden in chloropentafluorosulfanylation; that is, an anti‐stereoselective variant of SF5Cl addition across sulfone‐based BCBs can be achieved by using inexpensive copper salt additives. Considering the SF5 group and CBs have been employed individually as nonclassical bioisosteres, structural aspects of these unique SF5‐CB “hybrid isosteres” were then contextualized using SC‐XRD. From a mechanistic standpoint, chloropentafluorosulfanylation ostensibly proceeds through a curious polarity mismatch addition of electrophilic SF5 radicals to the electrophilic sites of the BCBs. Upon examining carbonyl‐containing BCBs, we also observed rare instances whereby radical addition to the 1‐position of a BCB occurs. The nature of the key C(sp3)−SF5 bond formation step – among other mechanistic features of the methods we disclose – was investigated experimentally and with DFT calculations. Lastly, we demonstrate compatibility of SF5‐CBs with various downstream functionalizations.
Radical detection and electron‐spin resonance (ESR) monitoring in polymer materials irradiated with gamma and X‐rays: Polyethylene and polypropylene
Authors: Krieguer Blanche , Marque Sylvain R. A. , Dorey Samuel , Dupuy Nathalie , Girard Fabien , Girard‐Perier Nina , Kuntz Florent , Ludwig Nicolas 
Published: January 2024

AbstractWhen ionizing radiations interact with polymers, free radicals are generated and are known to be the initiating species for the modification in materials. Monitoring and identifying free radicals after irradiation allow assessing the impact of X‐rays and gamma rays on materials. A comparative study has been performed on materials made from polypropylene and polyethylene after irradiation by the two irradiation technologies. Electron spin resonance (ESR) signal has been monitored up to 380 days when signal was still present. ESR signals, concentration profiles, and kinetics were observed after X‐rays and gamma rays.
Recycling decommissioned polyamide 11: An approach to handle a previously unwanted material
Authors: de Albuquerque Dias Frederico Gonçalves , Veiga Amanda G. , Gomes Antônio Pedro A. da C. P. , Rocco Maria Luiza M. , da Costa Marysilvia F. 
Published: January 2024

AbstractPolyamide 11 (PA11) is a polymer used in flexible lines for oil prospection due to its properties. After the decommissioning of the lines, the materials used are discarded in landfills or left in the ocean. As developing a sustainable economy is of utmost importance, reusing these discarded materials would be a step in the right direction. This research focused on examining two kinds of PA11 previously used in flexible lines to see their properties changed compared to virgin PA11 and to infer if they can still be reused. Chemical, thermal, and mechanical analysis were employed to analyze the PA11 that came from the two oilfields and recycled ones that were hot pressed with an unused PA11 in a 50/50 wt% proportion. Results indicate that one of the oilfield samples was less degraded than the other one, which provided better mechanical properties, and the same pattern happened with the recycled samples, indicating that some properties such as viscosity, plasticizer content, and crystallinity need to be evaluated before taking in consideration the reuse (be it recycling or repurposing) of this type of polymers in consideration.
Investigation on promotion effect of oxidative stabilization for pitch‐based fiber by co‐carbonization of coal tar pitch and atmospheric residual
Authors: Niu Hao , Miao Guihua , Shen Wenzhong , Qu Shijie 
Published: January 2024

AbstractAs a pivotal step in the preparation of carbon fiber, oxidative stabilization not only plays a crucial role in maintaining fibrous morphology but also contributes significantly to enhance mechanical properties of resultant carbon fiber. Due to high activation energy of pitch molecules reaction with oxygen and the sluggish diffusion of oxygen within the fiber, the improvement of oxidative stabilization efficiency faces significant challenges. Atmospheric residual (AR) has a high and easily oxidized aliphatic structure. Spinnable pitch is synthesized by co‐carbonization of coal tar pitch (CTP) and AR at a ratio of 3:1 in this work. Its methylene bridge bond ratio is 4.45% and have an appropriate amount aliphatic structure, which makes pitch molecular more linear and naphthenic. Excessive addition of AR is detrimental to spinning performance. The most optimal oxidative stabilization temperature of as‐spun fiber was 280°C, which is lower than that of fiber produced by CTP alone (300°C), displaying a higher oxidative stabilization efficiency. The obtained pitch‐based carbon fiber shows excellent mechanical properties with tensile strength of 999.0 ± 80.1 MPa and Young's modulus of 57.7 ± 3.5 GPa. The co‐carbonization by two different substances has been applied in manufacturing carbon fiber, providing a facile approach to accelerate the oxidative stabilization of pitch fiber.
Poly(β‐amino ester) based solid polymer electrolytes for lithium‐ion batteries
Authors: Majumdar Svensson Orpita , Melander Bowden Tim 
Published: January 2024

AbstractIn this paper, we present the synthesis of poly(β‐amino ester)‐based solid polymer electrolytes (SPE) from off‐stoichiometric acrylate‐amine formulations using one‐step, catalyst and solvent free aza‐Michael addition. By varying the monomers, the pendant functionality of the polymer chain structure could be altered. All synthesized polymers yield freestanding and easy to handle electrolyte films and hence are evaluated as a new class of SPEs. The SPE with 1,4‐butanediol diacrylate and propylamine showed the highest conductivity of 1.15 × 10−7 S cm−1 at 30°C with 10 wt% lithium bis(trifluoromethanesulfonyl)imide. Because of the presence of the various functional groups in the structure, the polymer chain aids in the movement of both the anion and the cation.
Will sentiment analysis need subculture? A new data augmentation approach
Authors: Wang Zhenhua , He Simin , Xu Guang , Ren Ming 
Published: January 2024

AbstractNowadays, the omnipresence of the Internet has fostered a subculture that congregates around the contemporary milieu. The subculture artfully articulates the intricacies of human feelings by ardently pursuing the allure of novelty, a fact that cannot be disregarded in the sentiment analysis. This paper aims to enrich data through the lens of subculture, to address the insufficient training data faced by sentiment analysis. To this end, a new approach of subculture‐based data augmentation (SCDA) is proposed, which engenders enhanced texts for each training text by leveraging the creation of specific subcultural expression generators. The extensive experiments attest to the effectiveness and potential of SCDA. The results also shed light on the phenomenon that disparate subcultural expressions elicit varying degrees of sentiment stimulation. Moreover, an intriguing conjecture arises, suggesting the linear reversibility of certain subcultural expressions.