bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardization of 3D printing parameters to control the size and shape of pores in Polylactic acid scaffolds
Authors: Pérez‐Sánchez Lucía , Ortiz de la O Misael A. , Álvarez‐Pérez Marco A. , Llaguno‐Munive Monserrat , Chanes‐Cuevas Osmar A. , Serrano‐Bello Janeth 
Published: February 2024

AbstractThe challenge of three‐dimensional (3D) printing by polymeric extrusion in tissue bioengineering is to control with precision the microarchitecture and porous interconnectivity of scaffolds, as well as search for models that allow and facilitate the development of personalized constructs that meet optimal characteristics for the regeneration of significant bone defects. In this study, anatomically accurate scaffolds were designed and printed to a critical size defect from a microtomography image of the rat calvaria. Different software is used to design a scaffold with exact anatomy. With Ultimaker Cura software, distinct printing parameters were standardized, permitting the printing of different types of pores and graded porosity scaffolds, with exact adaptation to the bone defect, utilizing a commercial 3D printer with a fused deposition modeling technique and compensating for the limitations of the method. The scaffolds were characterized by evaluating their mechanical properties and surface characteristics (pore size and porosity), employing scanning electron microscopy images, verifying that the size and shape of the pores were controlled, and evaluating cell viability and cell distribution on the 3D printed scaffold. Therefore, this work proves that by standardizing the printing parameters, it was possible to print a unique customized scaffold, controlling the shape and size of pores.
Analyzing the effect of user‐generated content on studio performance: A combined approach
Authors: Liu Yang 
Published: February 2024

AbstractThis research explores how user‐generated content (UGC) influences the performance of studios. Our dataset included both structured and unstructured UGC, analyzed through a hybrid of statistical techniques and machine learning algorithms. The findings revealed a positive relationship between UGC and both box office revenues and stock market performance. Additionally, classical machine learning methods demonstrated exceptional capabilities in accurately classifying the data. The insights from this study offer valuable marketing strategies for studio marketing managers and studio executives in leveraging social networks effectively.
Perspectives of the World Health Organization's physical activity guidelines among patients with musculoskeletal conditions: A mixed‐methods survey
Authors: Rickenbach Amelia , Acheampong Michael Kyereme , Bogar Alison , Booth Gregory 
Published: February 2024

AbstractIntroductionPhysical activity (PA) promotion is a core element of musculoskeletal rehabilitation. Many people with musculoskeletal conditions do not meet PA guidelines, such as those provided by the World Health Organization (WHO). This study aimed to explore the level of awareness and perspectives on the WHO PA guidelines among people with musculoskeletal conditions and identify how patients can be supported with PA in clinical practice.MethodsA mixed‐method cross‐sectional survey was conducted using a uniquely developed questionnaire, which was disseminated to patients attending outpatient physiotherapy or occupational therapy appointments. The questionnaire collected data on participant characteristics, awareness and perspectives on the WHO guidelines and suggestions for supporting patients with PA in clinical practice. Descriptive statistics and content analysis were used to analyse the quantitative and qualitative data respectively.ResultsOne‐hundred and two responses were included in the analysis. Forty‐two percent of respondents were aware of the guidelines, 50% knew why they existed and 53% felt they were achievable. Perspectives varied, ranging from the guidelines being positive and aiding motivation to being unachievable. Some respondents felt an individualised approach is required. Suggestions for supporting patients with PA included facilitating social support, providing education, exercise groups and personalised advice, and signposting to community services.ConclusionThere is limited awareness of the WHO PA guidelines and a variety of perspectives on the guidelines among patients with musculoskeletal conditions. There is a need to enhance the promotion of the guidelines in clinical practice, whilst considering local context and individual patient's circumstances.
A computational dual‐porosity approach for the coupled hydro‐mechanical analysis of fractured porous media
Authors: Khoei Amir R. , Taghvaei Mahtab 
Published: February 2024

AbstractDual‐porosity simulation is one of the most used and efficient approaches in modeling fractured porous media. The performance of this approach is highly dependent on the accuracy of the definition of matrix‐fracture transfer shape factor. In this paper, a two‐step computational algorithm is developed to enhance the accuracy of the dual‐porosity method in modeling large‐scale deformable porous media, particularly in the transient stage when the conventional dual‐porosity models are associated with some errors. Moreover, in the proposed finite element method (FEM)‐based algorithm, the interaction between the fluid and solid phases is taken into account using a modified expression for the conventional shape factor. To this end, an extended relationship is derived to calculate the hydro‐mechanical shape factor for deformable saturated porous media. An appropriate unit cell along with the consistent boundary conditions is introduced, and the corresponding hydro‐mechanical shape factor is numerically evaluated for the unit cell at each time step. Finally, the calculated time‐varying shape factors are employed in a dual‐porosity framework to simulate various case studies and investigate the influence of different parameters, including the boundary conditions, the fracture to matrix permeability ratio, and the fracture compressibility coefficient on the hydraulic and hydro‐mechanical time‐varying shape factors. Numerical simulations are carried out by employing the proposed dual‐porosity algorithm through two general problems and the results are compared with the fine‐grid direct numerical simulation. The results are promising and show that the present algorithm effectively and efficiently increases the precision of the dual‐porosity method in modeling large‐scale deformable problems.
Comparison of health care costs following sleeve gastrectomy versus Roux‐en‐Y gastric bypass among patients with type 2 diabetes
Authors: Argetsinger Stephanie , LeCates Robert F. , Zhang Fang , Ross‐Degnan Dennis , Wharam James F. , Arterburn David E. , Fernandez Adolfo , Lewis Kristina H. 
Published: February 2024

AbstractObjectiveThe objective of this study was to compare the impact of sleeve gastrectomy (SG) and Roux‐en‐Y gastric bypass (RYGB) on overall and diabetes‐specific health care costs among patients with type 2 diabetes.MethodsThis retrospective cohort study examined patients with type 2 diabetes after SG and RYGB using data from Optum's deidentified Clinformatics® Data Mart database. The matched study group included 9608 patients who underwent SG or RYGB and were enrolled between 2007 and 2019. The primary outcomes assessed were overall and diabetes‐specific health care costs.ResultsHealth care costs associated with type 2 diabetes declined substantially in the first few years following both SG and RYGB. RYGB was associated with a larger decrease in pharmacy costs, as well as type 2 diabetes‐specific office and laboratory costs. SG was associated with lower total health care costs in the first three follow‐up periods and lower acute care costs in the first 2 years after surgery.ConclusionsIn this nationwide study, patients with type 2 diabetes at baseline undergoing RYGB appear to experience a reduced need for ambulatory type 2 diabetes monitoring and reduced requirements for antidiabetes medication but, despite this, did not experience an overall medical cost–benefit in the first few years after RYGB versus SG.
Lightweight three‐dimensional woven Kevlar/glass hybrid composites with enhanced mechanical, dielectric, and thermal insulation properties
Authors: Zheng Liangang , Wang Ruijie , Yang Xiaori , Zhang Kun , Chen Yi , Xu Fujun 
Published: February 2024

AbstractPolymer composites with lightweight, ultralow dielectric constant, excellent thermal insulation and mechanical properties are in high demand in aerospace, transport, wireless communications and other fields. In this work, the three‐dimensional woven Kevlar/glass hybrid composites (3DKGC) with lightweight, high strength, excellent dielectric and thermal insulation properties were obtained with the Kevlar fiber and glass fiber as the raw materials. The results showed that the volume content of air in 3DKGC is over 82% and the volume density is as low as 0.29 g·cm−3, while the compression strength is as high as 7.68 MPa. 3DKGC exhibits an ultra‐low dielectric constant of 1.21. The wave transmission performance of 3DKGC was simulated using the CST software. The simulation results showed that 3DKGC has a return loss of 0.036 and a gain of 0.9982. Moreover, the 3DKGC provides superior thermal insulation than three‐dimensional woven Kevlar composites (3DKC) and conventional polystyrene foams. In summary, this work offers an attractive material that holds significant potential for application in aerospace, wireless communications and other fields where lightweight multi‐purpose composites are required.Highlights
3D woven Kevlar/glass hybrid composites (3DKGC) were proposed and fabricated.
3DKGC exhibits low density of 0.29 g·cm−3 but high compression stress (7.68 MPa).
3DKGC possesses outstanding dielectric and thermal insulation properties.
3DKGC leverages the benefits of cost‐effectiveness and holistic functionality.
Treatment readiness and prognosis for problematic smartphone use: Evaluation of the Stages of Change, Readiness, and Treatment Eagerness Scale (SOCRATES) and log data
Authors: Kobayashi Nanase , Jitoku Daisuke , Mochimatsu Ryoko , Hamamura Toshitaka , Honjo Masaru , Takagi Shunsuke , Sugihara Genichi , Takahashi Hidehiko 
Published: February 2024

AbstractAimWhile moderate smartphone use contributes to information gathering and relationship building, excessive smartphone use, also referred to as problematic smartphone use (PSU), has raised concerns because of its addictive nature and associated health consequences. This study aimed to investigate the relationship between treatment readiness and prognosis in individuals with PSU and to assess the predictive ability of smartphone log data in evaluating treatment readiness.MethodsA sample of 47 patients with PSU participated in this study. Treatment readiness was assessed using the Stages of Change, Readiness, and Treatment Eagerness Scale (SOCRATES), and log data were collected using a smartphone log application.ResultsThe results showed a significant correlation between baseline SOCRATES scores and the difference in Global Assessment of Functioning scores between baseline and 6 months (Spearman's ρ = 0.640, P‐value = .001), suggesting that treatment readiness may explain part of the treatment outcomes (Pearson's r2 = 0.379, P‐value = 0.032). In addition, baseline log data, including the log acquisition rate, showed a positive correlation with treatment readiness (Spearman's ρ = 0.328, P‐value = 0.045).ConclusionThese findings provide valuable insights into the relationship between treatment readiness and clinical outcomes in patients with PSU, and suggest the potential of log data as objective indicators of treatment motivation.
Integrated environmental and genomic analysis reveals the drivers of fine‐scale divergence and local adaptation in northern populations of two wild rice species in China
Authors: Chen Yuhong , Chen Hao , He Zhi‐Zhou , Tian De Feng , Dong Shanshan , Liu Yan , Wang Yuguo , Zhang Wenju , Li Linfeng , Yang Ji , Song Zhiping 
Published: February 2024

Societal Impact StatementCrop wild relatives represent precious genetic resources for crop improvement. Investigating their local adaptation to marginal environments is important for the utilization of wild genetic resources. Oryza officinalis and Oryza granulata are wild relatives of cultivated rice and possess genes that convey resistance to insects, disease, and tolerance to shade and drought. The northern edge for the distribution of these two lies in China where populations are facing habitat destruction. This study found that the northern marginal populations of both species have adapted to local conditions, with specific implications for the conservation and utilization of wild rice.Summary

O. officinalis and O. granulata, wild relatives of cultivated rice, represent important gene reservoirs with the potential to improve rice with respect to insect resistance and stress tolerance. However, the northern marginal populations of these two species in China are facing habitat destruction.
Here, we investigated the genetic diversity and divergence of northern marginal populations of O. officinalis and O. granulata. The genomic variation of two species was examined by whole‐genome sequencing on 357 individuals. Generalized dissimilarity modeling was applied to investigate the effects of geographic and environmental isolation on population differentiation. Genetic‐environment association analysis and genome‐wide FST outlier scans were used to identify environmentally driven signals of selection.
The marginal populations of both species exhibited low genetic diversity and obvious genetic differentiation stemmed from the joint effects of isolation by geographic distance and the environment. Both genomes exhibited specific signals of adaptation to cold environments in the north.
Investigation of the divergence and adaptation of marginal populations of O. officinalis and O. granulata will help us to determine how wild rice can adapt to local environments, thus allowing for the development of scientific conservation policies and the identification of new genetic resources for rice with improved resistance.
Management of surgical problems in children on home invasive mechanical ventilation
Authors: Ergun Ergun , Gollu Gulnur 
Published: February 2024

AbstractThe management of surgical problems in children on home invasive mechanical ventilation (HIMV) requires a comprehensive and multidisciplinary approach. HIMV is a critical intervention for children with chronic respiratory failure, as it allows them to live at home with their families while receiving life‐sustaining ventilatory support. However, the long‐term use of HIMV exposes these children to potential surgical complications related to their underlying conditions, tracheostomy tubes, ventilator devices, and gastrostomy tubes for enteral feeding. This manuscript aims to provide a detailed overview of the identification and recognition of surgical problems in children on HIMV, as well as strategies to solve these problems effectively.
Effects of highly effective modulator therapy on the dynamics of the respiratory mucosal environment and inflammatory response in cystic fibrosis
Authors: Atteih Samar E. , Armbruster Catherine R. , Hilliam Yasmin , Rapsinski Glenn J. , Bhusal Junu Koirala , Krainz Leah L. , Gaston Jordan R. , DuPont Matthew , Zemke Anna C. , Alcorn John F. , Moore John A. , Cooper Vaughn S. , Lee Stella E. , Forno Erick , Bomberger Jennifer M. 
Published: February 2024

AbstractBackgroundWhile the widespread initiation of elexacaftor/tezacaftor/ivacaftor (ETI) has led to dramatic clinical improvements among persons with cystic fibrosis (pwCF), little is known about how ETI affects the respiratory mucosal inflammatory and physiochemical environment, or how these changes relate to lung function.MethodsWe performed a prospective, longitudinal study of adults with CF and chronic rhinosinusitis (CF‐CRS) followed at our CF center (n = 18). Endoscopic upper respiratory tract (paranasal sinus) aspirates from multiple visit dates, both pre‐ and post‐ETI initiation, were collected and tested for cytokines, metals, pH, and lactate levels. Generalized estimating equations were used to identify relationships between ETI and upper respiratory tract (URT) biomarker levels, and between URT biomarkers and lung function or clinical sinus parameters.ResultsETI was associated with decreased upper respiratory mucosal cytokines B‐cell activating factor (BAFF), IL‐12p40, IL‐32, IL‐8, IL‐22 and soluble tumor necrosis factor‐1 (sTNFR1), and an increase in a proliferation‐inducing ligand (APRIL) and IL‐19. ETI was also associated with decreased URT levels of copper, manganese, and zinc. In turn, lower URT levels of BAFF, IL‐8, lactate, and potassium were each associated with ~1.5% to 4.3% improved forced expiratory volume in 1 s (FEV1), while higher levels of IFNγ, iron, and selenium were associated with ~2% to 10% higher FEV1.ConclusionsOur observations suggest a dampening of inflammatory signals and restriction in microbial nutrients in the upper respiratory tract with ETI. These findings improve our understanding of how ETI impacts the mucosal environment in the respiratory tract, and may give insight into the improved infectious and inflammatory status and the resulting clinical improvements seen in pwCF.
The impact of undergoing elective pediatric lung resection during respiratory syncytial virus peak season on patient outcomes: A nationwide retrospective analysis
Authors: Salvi Pooja S. , Canner Joseph K. , Coons Barbara , Cowles Robert A. , Engwall‐Gill Abigail J. , Kunisaki Shaun M. , Penikis Annalise B. , Schneider Eric , Sferra Shelby R. , Solomon Daniel G. 
Published: February 2024

AbstractObjectivesObservational data to support delaying elective pediatric thoracic surgery during peak respiratory viral illness season is lacking. This study evaluated whether lung surgery during peak viral season is associated with differences in postoperative outcomes and resource utilization.MethodsA retrospective observational cohort study was performed using the Pediatric Health Information System (PHIS). Patients with a congenital lung malformation (CLM) who underwent elective lung resection between 1 January 2016 and 29 February 2020 were included. Respiratory syncytial virus (RSV) incidence was used as a proxy for respiratory viral illness circulation. Monthly hospital‐specific RSV incidence was calculated from PHIS data, and peak RSV season was defined by Centers for Disease Control data. Multivariable regression models were built to identify predictors of postoperative mechanical ventilation, which was the main outcome measure, as well as secondary outcomes including 30‐day readmission after lung resection, postoperative length of stay (LOS) and hospital billing charges.ResultsOf 1542 CLM patients identified, 344 (22.3%) underwent lung resection during peak RSV season. 38% fewer operations were performed per month during peak RSV season than during off‐peak months (p < .001). Children who underwent surgery during peak RSV season did not differ from the off‐peak group in terms of age at operation, race, or comorbid conditions (i.e., congenital heart disease, newborn respiratory distress, and preoperative pneumonia). There was no association between hospital‐specific RSV incidence at the time of surgery and postoperative mechanical ventilation, postoperative LOS, 30‐day readmission rate or hospital billing charges.DiscussionPerforming elective lung surgery in children with CLMs during peak viral season is not associated with adverse surgical outcomes or increased utilization of healthcare resources.
Hydrogen safety effect calculation (dispersion and thermal radiation effects) for determination of siting and safe distance
Authors: Venkatesan Rubachandran , Harun Razif , Mohamed Yusoff Hamdan , Abdul Razak Musab 
Published: February 2024

AbstractThe main aim of this study was to evaluate the potential effect of dispersion, thermal radiation, and explosion from a poly‐bed pressure swing adsorption (PSA) unit with its surrounding facility to determine its safety distance. Thus, the Shell FRED (fire, release, explosion, and dispersion) consequence modeling was used to predict the impact of a release scenario and assist in designing, developing, and maintaining safe operation. This study was intended to calculate dispersion contours to 50% lower flammable limit (LFL) and 100% LFL, thermal impacts of radiation flux levels of 4, 5, 12.5, and 37.5 kW/m2 at a distance, and including explosive effects of 0.1, 0.2, and 0.35 bar to the chosen target. Based on the findings, it was found that, to avoid exposure to heat radiation of 12.5 kW/m2 from the PSA unit, equipment should be located at a minimum distance of 20.84 m. Meanwhile, process modules and buildings must be located at a minimum distance of 13.8 m. The explosive nature of hydrogen makes on‐site handling and storage more challenging than fossil fuels. The findings of this study will have important implications for the future handling and storage of hydrogen as a potential fuel.
Layer‐by‐layer assembled decomposable nanocapsules for light‐responsive release of pesticide imidacloprid on Aphis craccivora Koch
Authors: Gao Yiyun , Xiao Wenjun , Gu Chenhua , Yu Sheng , Li Shengke , Zou Aihua 
Published: February 2024

AbstractBACKGROUNDConventional pesticide formulations are often inefficient because of low biological uptake after spraying. Controlled release nanopesticides can release pesticides precisely in response to specific stimuli, thereby killing pests and pathogens using the least effective concentration. This study aims to develop nanocapsule‐based photo‐decomposable nanopesticides for efficient pesticide control.RESULTSThe target nanopesticides were successfully fabricated using layer‐by‐layer assembly of the negative azobenzene‐grafted hyaluronic acid (azo‐HA) and positive polydimethyldiallylammonium chloride (polyDADMAC), confirmed by UV‐visible, dynamic light scattering, Zeta potential and transmission electron microscopy measurements. The particle size and Zeta potential of the fabricated nanocapsules were 220 nm and +46.1 mV, respectively, and the nanocapsules were found to remain stable for up to 30 days. The optimized drug loading and encapsulation ratio of imidacloprid (IMI) in IMI/azo‐HA@polyDADMAC were 21.5% and 91.3%, respectively. Cumulative release of IMI from the nanopesticides increased from ~50% to ~95% upon UV light irradiation (365 nm). The half lethal concentration (LC50) value of the nanopesticides toward Aphis craccivora Koch decreased from 2.22 to 0.55 mg L−1 upon UV light irradiation.CONCLUSIONThe trans to cis transformation of the azo group in HA decomposed IMI/azo‐HA@polyDADMAC nanopesticides upon UV irradiation, thus facilitating the release of IMI, resulting in a decrease in the concentration of pesticides required for efficient pesticide control. Our work demonstrated the great potential of light‐responsive nanocapsules as a controlled release nanocarrier for efficient and eco‐friendly pesticide control in sustainable agriculture. © 2024 Society of Chemical Industry.