bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct visualization of left ventricular free wall rupture by levocardiography
Authors: Krakau Ingo , Lapp Harald , Wolfertz Judith , Gülker Hartmut 
Published: October 2002

AbstractTwo cases of left ventricular free wall rupture and one case of combined left ventricular free wall and ventricular septal rupture are described where ventriculography played a key role in diagnosis. In all three cases of patients with acute myocardial infarction, identification and localization of the defect was made by angiography. This report illustrates the safety and feasibility of ventriculography in patients with suspected cardiac rupture. Cathet Cardiovasc Intervent 2002;56:238–242. © 2002 Wiley‐Liss, Inc.
Immediate protamine administration and sheath removal following percutaneous coronary intervention: A prospective study of 429 patients
Authors: Ducas John , Chan Michael C.Y. , Miller Anthony , Kashour Tarek 
Published: October 2002

AbstractWe tested the approach of reversing anticoagulation following PCI and immediate sheath removal in 429 consecutive patients. On completion of the PCI, protamine was administered, and the vascular sheath was immediately removed. Stents were used in 364 patients (85%) and GP IIb/IIIa inhibitors were used in 52 patients (12%). Time to achieve hemostasis was 30 ± 17 min. Minor groin bleeding occurred in six patients. One patient required repair of femoral pseudoaneurysm. Mean creatine kinase at 8 and 16 hr post‐PCI were 129 ± 35 and 145 ± 32 units, respectively. Creatine kinase rose to > 3 times normal in 12 out of 350 patients (3.4%). Prior to 48 hr, eight patients (1.9%) required emergency PCI or coronary bypass surgery. Follow‐up at 30 days observed no deaths and only three target vessel revascularizations (0.7%). In conclusion, immediate reversal of anticoagulation and sheath removal after PCI is safe and feasible. Cathet Cardiovasc Intervent 2002;56:196–199. © 2002 Wiley‐Liss, Inc.
Pulmonary venous pressure: Relationship to pulmonary artery, pulmonary wedge, and left atrial pressure in normal, lightly sedated dogs
Authors: Chaliki Hari P. , Hurrell David G. , Nishimura Rick A. , Reinke Rebekah A. , Appleton Christopher P. 
Published: October 2002

AbstractBecause pulmonary venous pressure has never been measured, it is unclear whether pulmonary wedge pressure measures left atrial pressure, as commonly assumed, or pressure more upstream in the pulmonary venous or capillary beds. Fluid‐filled mean pulmonary artery and pulmonary wedge pressure were compared with pulmonary venous and left atrial pressure obtained with high‐fidelity micromanometer catheters in eight lightly sedated dogs over a physiologic range of filling pressures. In all conditions, mean pulmonary wedge pressure was virtually identical (r = 0.99) to mean left atrial pressure (slope = 0.99; intercept = −0.46 mm Hg). At the same time, mean pulmonary venous pressure (17.1 ± 6.5 mm Hg) was intermediate between mean pulmonary artery pressure (20.2 ± 6.2 mm Hg) and mean pulmonary wedge pressure (13.3 ± 6.2 mm Hg; P < 0.0001) or mean left atrial pressure (13.4 ± 6.3 mm Hg; P < 0.0001). These relationships were maintained over normal and increased pressure ranges. As measured by conventional flow‐directed pulmonary catheters, mean pulmonary wedge pressure accurately reflects left atrial pressure in lightly sedated, spontaneously breathing normal dogs. Cathet Cardiovasc Intervent 2002;56:432–438. © 2002 Wiley‐Liss, Inc.
Radiofrequency‐assisted atrial septoplasty for an intact atrial septum in complex congenital heart disease
Authors: Du Marchie Sarvaas Gideon J. , Trivedi Kalyani R. , Hornberger Lisa K. , Lee K. Jin , Kirsh Joel A. , Benson Lee N. 
Published: October 2002

AbstractSeptoplasty of the atrial septum was performed with sequential balloon dilation following radiofrequency‐assisted perforation of an intact atrial septum in two newborn infants with hypoplastic left heart syndrome and one with double‐outlet right ventricle. Cathet Cardiovasc Intervent 2002;56:412–415. © 2002 Wiley‐Liss, Inc.
Patterns of late diameter change after balloon angioplasty of branch pulmonary artery stenosis: Evidence for vascular remodeling
Authors: Bartolomaeus Georg , Radtke Wolfgang A.K. 
Published: October 2002

AbstractAngiographic diameters of 36 pulmonary artery stenoses (26 patients; median age, 3.3 years) before and after balloon angioplasty and at repeat angiography after 2–64 months were compared to diameters of 31 untreated pulmonary artery stenoses (20 patients) at a median age of 3.6 years and after 4–76 months. In the treatment group, an acute diameter gain of > 50% was achieved in 58%. On follow‐up, 16 lesions remained unchanged, 6 lesions had > 20% late loss, and 12 lesions had > 20% late gain. The three patterns of vascular response were confirmed when compared to the control group. In the late gain group, overall diameter increase was 125% compared to 41% initial increase. The net result was a long‐term success rate of 57%. Patterns of late diameter change appear to suggest vascular remodeling after balloon angioplasty of pulmonary arteries. Cathet Cardiovasc Intervent 2002;56:533–540. © 2002 Wiley‐Liss, Inc.
Carotid stent‐supported angioplasty in a patient with symptomatic and critical aortic stenosis
Authors: Li Steven Siu‐Lung , Yiu Siu‐Fung , Chiang Chung‐Seung 
Published: October 2002

AbstractWe report a successful carotid angioplasty in a patient with symptomatic and critical aortic stenosis. The safety and feasibility of this technique in this scenario have not been well established and reported. With careful planning and technique, we believe the procedure should be safe and feasible. Cathet Cardiovasc Intervent 2002;56:498–502. © 2002 Wiley‐Liss, Inc.
Successful treatment of iatrogenic renal artery perforation with an autologous vein‐covered stent
Authors: Bates Mark C. , Shamsham Fadi M. , Faulknier Brett , Crotty Bradley 
Published: October 2002

AbstractA 72‐year‐old woman developed severe flank pain associated with hemodynamic compromise immediately after a J‐curve guidewire was inadvertently advanced into the right renal artery during cardiac catheterization. Contrast extravasation consistent with perforation of the main renal artery was seen on abdominal angiography. The perforation was successfully sealed using a premounted coronary stent that was covered with an autologous antecubital vein. Wide stent patency without aneurismal dilatation was confirmed on a 2‐year follow‐up renal angiogram. Cathet Cardiovasc Intervent 2002;57:39–43. © 2002 Wiley‐Liss, Inc.
Catheter closure of accessory pulmonary blood flow after bidirectional Glenn anastomosis using Amplatzer duct occluder
Authors: Ebeid Makram R. , Gaymes Charles H. , Joransen James A. 
Published: October 2002

AbstractAdditional source of pulmonary blood flow in patients with bidirectional cavopulmonary anastomosis (Glenn shunt) may cause elevation of the pulmonary artery pressure precluding safe completion of the Fontan operation. A case is presented with single‐ventricle bidirectional cavopulmonary anastomosis and additional flow from the ventricle to the pulmonary artery resulting in elevated Glenn pressure. The communication was successfully occluded using Amplatzer duct occluder with satisfactory reduction in the Glenn pressure. Cathet Cardiovasc Intervent 2002;57:95–97. © 2002 Wiley‐Liss, Inc.
O2‐PLS for qualitative and quantitative analysis in multivariate calibration
Authors: Trygg Johan 
Published: October 2002

AbstractIn this paper the O‐PLS method [1] has been modified to further improve its interpretational functionality to give (a) estimates of the pure constituent profiles in X as well as model (b) the Y‐orthogonal variation in X, (c) the X‐orthogonal variation in Y and (d) the joint X–Y covariation. It is also predictive in both ways, X ↔ Y. We call this the O2‐PLS approach. In earlier papers we discussed the improved interpretation using O‐PLS compared to the partial least squares projections to latent structures (PLS) when systematic Y‐orthogonal variation in X exists, i.e. when a PLS model has more components than the number of Y variables. In this paper we show how the parameters in the PLS model are affected and to what degree the interpretational ability of the PLS components changes with the amount of Y‐orthogonal variation. In both real and synthetic examples, the O2‐PLS method provided improved interpretation of the model and gave a good estimate of the pure constituent profiles, and the prediction ability was similar to the standard PLS model. The method is discussed from geometric and algebraic points of view, and a detailed description of this modified O2‐PLS method is given and reviewed. Copyright © 2002 John Wiley & Sons, Ltd.
Combining bilinear modelling and ridge regression
Authors: Høy Martin , Westad Frank , Martens Harald 
Published: October 2002

AbstractA method is presented for making principal component regression (PCR), partial least squares regression (PLSR) and other regressions based on bilinear modelling (BLM) less sensitive to overfit. The idea is to use generalized ridge regression to calculate the Y‐loadings in order to prevent small, uncertain values of the score vectors from causing inflation of variance in the regression coefficients. Thus we combine the stabilizing power of ridge regression with the modelling power and interpretability of bilinear models. The method is intended to provide better predictive ability and improved stability for regression models. Copyright © 2002 John Wiley & Sons, Ltd.
Studying the functional genomics of stress responses in loblolly pine with the Expresso microarray experiment management system
Authors: Heath Lenwood S. , Ramakrishnan Naren , Sederoff Ronald R. , Whetten Ross W. , Chevone Boris I. , Struble Craig A. , Jouenne Vincent Y. , Chen Dawei , van Zyl Leonel , Grene Ruth 
Published: October 2002

AbstractConception, design, and implementation of cDNA microarray experiments present
a variety of bioinformatics challenges for biologists and computational scientists.
The multiple stages of data acquisition and analysis have motivated the design
of Expresso, a system for microarray experiment management. Salient aspects
of Expresso include support for clone replication and randomized placement;
automatic gridding, extraction of expression data from each spot, and quality
monitoring; flexible methods of combining data from individual spots into information
about clones and functional categories; and the use of inductive logic programming
for higher‐level data analysis and mining. The development of Expresso is
occurring in parallel with several generations of microarray experiments aimed
at elucidating genomic responses to drought stress in loblolly pine seedlings.
The current experimental design incorporates 384 pine cDNAs replicated and
randomly placed in two specific microarray layouts. We describe the design
of Expresso as well as results of analysis with Expresso that suggest the
importance of molecular chaperones and membrane transport proteins in mechanisms
conferring successful adaptation to long‐term drought stress. Copyright ©
2002 John Wiley & Sons, Ltd.
Website Review: How to get the best from fission yeast genome data
Authors: Wood Valerie , Bähler Jürg 
Published: October 2002

AbstractResearchers are increasingly depending on various centralized resources
to access the vast amount of information reported in the literature and generated
by systematic sequencing and functional genomics projects. Biological databases
have become everyday working tools for many researchers. This dependency goes
both ways in that the databases require continuous feedback from the research
community to maintain accurate, reliable, and up‐to‐date information. The
fission yeast Schizosaccharomyces pombe has recently been sequenced,
setting the stage for the post‐genome era of this popular model organism.
Here, we provide an overview of relevant databases available, or being developed,
together with a compilation of Internet resources containing useful information
and tools for fission yeast. Copyright © 2002 John Wiley & Sons,
Ltd.
Contribution of chiral HPLC in tandem with polarimetric detection in the determination of absolute configuration by chemical interconversion method: Example in 1‐(thi)oxothiazolinyl‐3‐(thi)oxothiazolinyl toluene atropisomer series
Authors: Roussel Christian , Hart Nicholas , Bonnet Brice , Suteu Cristina , Hirtopeanu Anca , Kravtsov Victor Ch. , Luboradzki Roman , Vanthuyne Nicolas 
Published: October 2002

AbstractWe report the determination of the absolute configuration of eight stereoisomers in the series of chiral 1‐(thi)oxothiazolinyl‐3‐(thi)oxothiazolinyl toluene atropisomers 1–3, from the known absolute configuration of one stereoisomer, determined by X‐ray crystallography. The method uses the affiliation between signs of rotation of polarised light during chemical transformations which preserve the absolute configuration and also during rotation around a single pivot bond producing a compound of known configuration. The use of chiral HPLC in tandem with a chirality detector gives a decisive advantage since such correlation can be performed on a mixture of a very limited quantity of compounds, without tedious purification steps. The method shown as an example in this article, which uses chiral HPLC with chirality detection, may prove useful in many other cases where the determination of the absolute configuration is necessary and where a chemical interconversion method can be used on a microscale. Chirality 14:665–673, 2002. © 2002 Wiley‐Liss, Inc.
Chemoenzymatic synthesis and properties of Schiff bases containing (R)‐1‐(9‐anthryl)ethylamine
Authors: Roje Marin , Šunjić Vitomir 
Published: October 2002

AbstractRacemic 1‐(9‐anthryl)ethylamine (10), obtained in 70% overall yield from commercial 9‐cyanoanthracene, was kinetically resolved by the Candida antarctica A lipase‐catalyzed acetylation with isopropyl acetate as acyl donor, affording (R)‐(+)‐10 with 95.8% enantiomeric excess (e.e.) (E‐value 43.5), which afforded Schiff bases (R)‐4 and(R)‐8. 1H‐NMR, CD, and MM2 calculations offer a consistent picture of the conformational properties of these potential ligands and an explanation for the limited enhancement of enantioselectivity in cyclopropanation of styrene by their Cu(I) complexes, as compared with previously studied ligands in this series. Chirality 14:625–631, 2002. © 2002 Wiley‐Liss, Inc.
Cell migration and proliferation are not discriminatory factors in the in vitro sociologic behavior of bronchial epithelial cell lines
Authors: Matos Manuela , Raby Béatrice Nawrocki , Zahm Jean‐Marie , Polette Myriam , Birembaut Philippe , Bonnet Noël 
Published: October 2002

AbstractA model of cellular cohesion has been developed, which permits the in vitro study of the spatial and temporal distribution of two human bronchial cell lines. The spatial distribution of cells in culture was characterized from videomicroscopic recordings and analyzed using an algorithmic program of cellular sociology based on the use of three geometrical models: Voronoï's partition, Delaunay's graph, the and minimum spanning tree (MST). The results obtained suggested that the manner of cellular cohesiveness could be used to differentiate between the organizational behaviors of the cell lines: non‐invasive 16HBE14o‐ cells rapidly formed clusters with a cohesive organization, whereas invasive BZR cells remained isolated and were characterized by a non‐cohesive organization. Videomicroscopic and image analysis techniques also demonstrated that cell migration and proliferation are not discriminatory factors for explaining differences in the spatial organizations of the two cell lines. We concluded that the random nature of cell movement combined with the cell adhesion capacity are determinant factors in cell cluster formation. Cell Motil. Cytoskeleton 53:53–65, 2002. © 2002 Wiley‐Liss, Inc.
BPDE‐induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma risk
Authors: Zhu Yong , Spitz Margaret R. , Zheng Yun‐Ling , Hong Waun K. , Wu Xifeng 
Published: October 2002

AbstractBACKGROUNDTobacco exposure is an established risk factor for head and neck squamous cell carcinoma (HNSCC). Benzo[α]pyrene diol expoxide (BPDE), a main metabolic product of the tobacco smoke constituent benzo[α]pyrene, induces chromosomal aberrations at specific loci. Chromosomal aberrations in peripheral blood lymphocytes (PBLs) induced by BPDE may reflect individuals' genetic susceptibility to tobacco carcinogens.METHODSThis study was designed to detect BPDE‐induced aberrations in PBLs at locus 3p21.3 in cultured lymphocytic cells. Our hypothesis is that the presence of BPDE‐induced 3p21.3 aberrations is a biomarker of an individual's genetic susceptibility and that individuals with these aberrations are at an increased risk for HNSCC. PBL cultures from 52 cases and 54 controls were treated with 2 μM BPDE for 24 hours before the 3p21.3 aberrations were assessed by flourescence in situ hybridization. One thousand lymphocyte interphases were scored for each sample.RESULTSWe found that BPDE‐induced chromosome 3p21.3 aberrations occurred more frequently in cases (mean: 31.4 per 1000 cells) than in controls (mean: 22.1 per 1000 cells; P < 0.001). However, when 6q27 was selected as a control locus, no such difference was observed (P = 0.545). When the 75th percentile value of induced aberrations in the controls was used as a cutoff point to classify 3p21.3 BPDE‐induced sensitivity, 30 of the 52 cases (57.69%) and only 14 of the 54 controls (25.93%) were sensitive to BPDE exposure. This approach resulted in an odds ratio of 4.8 (95% confidence interval: 1.87–12.28) for HNSCC risk associated with BPDE‐induced 3p21.3 aberrations. There was also a dose‐response relationship between the number of BPDE‐induced aberrations at 3p21.3 and risk for HNSCC.CONCLUSIONSThe results from this study demonstrated that 3p21.3 may be a specific molecular target of tobacco carcinogens and that BPDE sensitivity at this locus may reflect an individual's genetic susceptibility to HNSCC. Cancer 2002;95:563–8. © 2002 American Cancer Society.DOI 10.1002/cncr.10689
Late recurrence in 1263 men with testicular germ cell tumors
Authors: Shahidi Mehdi , Norman Andrew R. , Dearnaley David P. , Nicholls Judy , Horwich Alan , Huddart Robert A. 
Published: October 2002

AbstractBACKGROUNDTesticular germ cell tumors are highly curable. However, 10–30% of patients have recurrence after initial treatment. The time–course of recurrence has implications for the duration of follow‐up. This study was undertaken to assess the risk and time–course of recurrence and to identify patients at higher risk of late recurrence.METHODSThe records of 1263 patients with primary testicular germ cell tumors presenting to the Royal Marsden Hospital between December 1979 and December 1993 were reviewed. In all, 255 episodes of recurrence were documented (including 44 patients with multiple recurrences) and used to calculate recurrence‐free survivals.RESULTSFifty‐three patients (15 seminomas; 38 nonseminomatous germ cell tumors [NSGCT]) had recurrence more than 2 years after initial presentation. A multivariate analysis of risk of recurrence after 2 years identified positive markers at presentation and the presence of differentiated teratomas in postchemotherapy surgical specimens as significant predictors. Very late recurrence (> 5 years) occurred mainly in patients with metastatic NSGCT (12 of 14 patients) with a 1% annual risk of recurrence between 5 and 10 years. Very late recurrence was also seen in one case of metastatic seminoma and one case of Stage I NSGCT managed by surveillance. Most late recurrences (n = 9) were detected at routine annual follow‐up visits but five had recurrences with symptoms leading to an unscheduled clinic visit.CONCLUSIONLate recurrences are rare in patients with testicular germ cell tumors and follow‐up to detect recurrence may not be needed after 5 years, except in those presenting with metastatic NSGCTs. Cancer 2002;95:520–30. © 2002 American Cancer Society.DOI 10.1002/cncr.10691
Clinical importance of serum interleukin‐18 and nitric oxide activities in breast carcinoma patients
Authors: Günel Nazan , Coşkun Uğur , Sancak Banu , Günel Uğur , Hasdemir Oğuz , Bozkurt Şükrü 
Published: October 2002

AbstractBACKGROUNDInterleukin‐18 (IL‐18) is a novel immunoregulatory cytokine that was known previously as interferon‐γ–inducing factor. IL‐18 levels can be used as a serum indicator for monitoring the clinical course of patients with hematologic malignancies and gastric carcinoma. Nitric oxide (NO) is a pleiotropic molecule that participates in the multistep processing of carcinogenesis.METHODSIn the current study, we measured serum IL‐18 and nitrate and nitrite levels in 38 metastatic and 26 nonmetastatic breast carcinoma patients and 16 healthy control subjects. Serum nitrate and nitrite levels were measured as an index of NO generation.RESULTSThe levels of serum IL‐18 and nitrate and nitrite were increased significantly in breast carcinoma patients compared with control subjects (P < 0.001). Serum IL‐18 levels were significantly higher in the metastatic patients compared with the nonmetastatic patients (P < 0.001). There was no difference in serum nitrate and nitrite levels between metastatic and nonmetastatic patients (P > 0.05). Patients with bone metastasis have higher serum IL‐18 levels and lower serum nitrate and nitrite levels compared with patients with liver, lung, and local metastasis (P < 0.001). There was no correlation among serum IL‐18, nitrate and nitrite, CA 15‐3, and carcinoemybryonic antigen levels (P > 0.05).CONCLUSIONSThese findings suggest that serum IL‐18 and nitrate and nitrite levels may be useful markers in monitoring metastatic breast carcinoma pateints. IL‐18 and NO activities in breast carcinoma patients with bone metastasis may be more valuable in the follow‐up of these patients. Cancer 2002;95:663–7. © 2002 American Cancer Society.DOI 10.1002/cncr.10705
Glycine and GABAA receptor subunits on Renshaw cells: Relationship with presynaptic neurotransmitters and postsynaptic gephyrin clusters
Authors: Geiman Eric J. , Zheng Wei , Fritschy Jean‐Marc , Alvarez Francisco J. 
Published: October 2002

AbstractInhibitory synapses with large and gephyrin‐rich postsynaptic receptor areas are likely indicative of higher synaptic strength. We investigated the presynaptic inhibitory neurotransmitter content (GABA, glycine, or both) and the presence and subunit composition of GABAA and glycine postsynaptic receptors in one example of gephyrin‐rich synapses to determine neurochemical characteristics that could also contribute to enhance synaptic strength. Hence, we analyzed subunit receptor expression in gephyrin patches located on Renshaw cells, a type of spinal interneuron that receives powerful excitatory and inhibitory inputs and displays many large gephyrin patches on its surface. GABAA and glycine receptors were almost always colocalized inside Renshaw cell gephyrin clusters. According to the subunit‐immunoreactivities detected, the composition of GABAA receptors was inferred to be either α3β(2or3)γ2, α5β(2or3)γ2, α3α5β(2or3)γ2 or a combination of these. The types of neurotransmitters contained inside boutons presynaptic to Renshaw cell gephyrin patches were also investigated. The majority (60–75%) of terminals presynaptic to Renshaw cell gephyrin patches contained immunocytochemical markers for GABA as well as glycine, but a proportion contained markers only for glycine. Significantly, 40% of GABAA receptor clusters were opposed to presynaptic boutons that contained only glycinergic markers. We postulate that GABA and glycine corelease, and the presence of α3‐containing GABAA receptors can enhance the postsynaptic current and contribute to strengthen inhibitory input on Renshaw cells. In addition, a certain degree of imprecision in the localization of postsynaptic GABAA receptors in regard to GABA release sites onto adult Renshaw cells was also found. J. Comp. Neurol. 444:275–289, 2002. © 2002 Wiley‐Liss, Inc.