bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metadichol: an inhibitor of zoonotic viruses; Nipah, Laasa, and rabies
Authors: raghavan Palayaakotai R 
Published: January 2024

Abstract
Zoonotic viruses, such as coronaviruses, the Ebola virus, the Zika virus, Nipah, Laasa, and rabies, can be transmitted from animals to humans (1). There is a need to develop inhibitors because they can potentially prevent or treat viral infections in humans and animals (2). Metadichol® is a nanoemulsion of long-chain alcohols that is a potent inhibitor of viruses. We present results of in vitro assays showing that it inhibits Laasa, rabies, and Nipah viruses at concentrations of 0.8 to 2.6 µg/ml. It is likely that the binding of metadichol to VDR ( vitamin D receptor) leads to regulation of c-MYC (MYC Proto-Oncogene, BHLH Transcription Factor (which controls expression of SP1(SP1 transcription factor), which is the key step to controlling the viral replication gene GSPT1(G1 To S Phase Transition 1). Since metadichol is commercially available and nontoxic, with an LD50 of more than 5000 mg/kg in rats, it could be useful in the treatment of such zoonotic diseases.
Characteristics of opinions in the societal and non-societal domains
Authors: Singh Loitongbam Gyanendro , Singh Sanasam Ranbir 
Published: January 2024

Abstract
With the increasing availability of user opinions on the web, analysis of the opinions across societal and non-societal topics is vital for tasks like opinion mining and sentiment analysis. In this study, societal topics are defined as topics or events related to social unrest, terrorist acts, or government policies. While general opinions, product reviews, movie reviews, and restaurant reviews are considered non-societal topics. There are abundant sentiment annotated resources for non-societal topics on the web. However, as social issues are regionally dependent, finding sentiment annotated resources for societal topics is challenging. To exploit the sentiment resources available for non-societal topics over societal topics, it is crucial to understand the difference in opinions between societal and non-societal topics. This study investigates the characteristics of opinions on societal and non-societal datasets through statistical analysis of text and network representations. Text analysis for societal and non-societal opinions is studied based on the corpus's word usage, sentiment word association, and homogeneity. From the graph perspective, the relation of the words is measured using traditional graph analysis methods such as clustering coefficient, connected component, and scale-free network analysis to understand the relation strength of words across the available sentiment resources. Various experimental investigations show that the vocabulary used in the product reviews and movie reviews datasets have similar sentiment word associations. While the vocabulary in the societal and consumer review datasets did not share any sentiment word associations, the non-societal sentiment resources may not be helpful in the societal domain. It is also observed that opinions on Twitter adhere to scale-free network properties, increasing the possibility of using social network analysis techniques to investigate sentiment analysis studies from a network perspective.
Excitation-Induced Conformational Changes in ecDHFR: Attenuable Luminance Element in Instant Reaction States
Authors: Chang Chia Yu , Thebeau Ronnie E , Chang Fang Yu 
Published: January 2024

Abstract
Dihydrofolate reductase (ecDHFR) is an enzyme that synthesizes 5, 6, 7, 8- synthesizes tetrahydrofolate. It can also be used to prepare a kind of the nucleotide precursor. The present research reports that when the ecDHFR molecule undergoes the reaction and is exposed to excitation. It becomes a stable fluorescent protein. Complexes formed through DHF and other mutants of ecDHFR covalent hydronium substrate, have shown electronic resonance effects. Based on the findings, microscale reactions are assumed to be governed by specific potential energy provided through bonding formation, electrostatic attraction, ionic force, and van der Waal forces in the hydrophobic instant steady state. The ability to generate a series of realistic excitation response ratios and compare the wild type and mutant ecDHFR before and after reaction will provide further insight into how ecDHFR dynamics work and the relation with image formation capability in the nuclear medicine imagine research.
Utilization of Perinatal Depression and Anxiety Assessment Tools in Routine Perinatal Care: a Call for the Integration and Implementation of Maternal Mental Health Services Into Perinatal Care in Ghana.
Authors: Karikari Mustapha , fuseini Ayamba Dramani , Bessing Barnabas , Adeleke Victor , Okafor Jane Akunna , Abdullai Isaka , Baxey Emma Sename 
Published: January 2024

Abstract
Background
This study intends to stimulate critical thinking and generate impactful discussions on the provision of holistic perinatal care. The rationale is to promote the exchange of ideas and collaboration among stakeholders to ensure that the training and practice of midwifery in Ghana become more robust and meet global standards. Additionally, it is meant to inform, prepare competent, resourceful, knowledgeable, and most importantly adaptable midwives who can contribute to and promote the overall health of the women in their care.
Objective
To explore midwives’ knowledge and understanding on soliciting the requisite information that impacts the psychological health of the perinatal women in their care during the perinatal period using globally validated and reliable assessment tools for depression and anxiety.
Methods
A structured questionnaire was used to collect data from the participants (midwives). The study was conducted in selected hospitals across all 16 regions in Ghana. A total of 319 midwives with varying degrees and experience working at different levels (teaching, municipal, regional and district hospitals) of the health care system in Ghana participated in the study. Basic descriptive quantitative analysis was used based on frequency tables, pie chart and graphical illustration to interpret the data.
Results
The participants have adequate knowledge on the impact of perinatal anxiety and depression on birth and maternal outcomes. However, the remains a huge deficit in their ability to use the validated and reliable assessment tools in recognizing clinical cues related to anxiety and depression among perinatal women. Surprisingly, over 50% of the midwives were unfamiliar with the commonly used assessment tools for depression and anxiety such as the EPDS and PHQ-9. Additionally, nearly 40% of the participants lack the requisite assessment skills for assessing perinatal anxiety and depression.
Conclusion
Perinatal mental health should be made a critical component of perinatal care, with midwives being well situated to recognize the manifestations of deteriorating mental health among the perinatal women in their care and provide the needed support and required level of supervision. It is therefore imperative to train midwives on basic mental health assessment skills and encourage them to incorporate mental health care into the delivery of routine perinatal care and services.
Estimating Short-Term Costs of NEET Youths: Evidence from Morocco
Authors: Liouaeddine Mariem 
Published: January 2024

Abstract
In this article we estimate the overall costs of the NEET youth population in Morocco in terms of public finance and opportunity costs focused on three of five aspects: unemployment, health, and girl mothers.
The results show that young rural women have the significant percentage of young NEETs in Morocco. The total costs of young NEET in terms of public finance is estimated to 60 592 858 600 Dhs in Morocco in 2019, equivalent to and in opportunity costs to an amount of 55 043 899 000Dhs.
Catchment response to climate change under CMIP6 scenarios: a case study of the Krishna River Basin
Authors: Anil Suram , P Anand Raj , Vema Vamsi Krishna 
Published: January 2024

Abstract

This study assessed the impacts of climate change on the water balance of the Krishna River Basin (KRB) in India. A frequency-based metric, known as symmetric uncertainty, was used to select the top 50% of global climate models (GCMs) from a pool of 18 Coupled Model Intercomparison Project Phase 6 (CMIP6) GCMs for hydrological modelling. The impact of climate change was projected for three future time frames, namely, near future (NF: 2026–2050), mid-future (MF: 2051–2075) and far future (FF: 2076–2100), using four scenarios from shared socio-economic pathways (SSPs): SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5. The Soil and Water Assessment Tool model was used to simulate climate change impact during historical and future periods in the basin. The results showed a significant increase in the annual average precipitation, surface runoff, water yield and streamflow in the future under all SSP scenarios. The increase in the projected annual average precipitation ranges from 12 to 54% for four SSP scenarios compared to the historical ensemble average. Future periods showed a shift in the monthly peak flows compared to the baseline period. More availability of water in the future in the KRB can be effectively used for various water management works.
Evaluating the photocatalytic degradation efficacy of 2,4,6-trichlorophenol: performance evaluation and influencing factors
Authors: Pipil Harsh , Yadav Shivani , Kumar Sunil , Haritash Anil Kumar 
Published: January 2024

Abstract

Chlorophenols are organic compounds that have garnered considerable attention in recent years because of their prevalent occurrence in the environment and associated harmful effects on ecosystems and human health. The current work investigated the photocatalytic oxidation of 2,4,6-trichlorophenol as a potential treatment option. The effects of different process-conditioning parameters were studied. Analytical-grade commercially available TiO2 reported 80% degradation, whereas nano-grade TiO2 resulted in complete removal in the same time duration. Furthermore, the study assessed the use of Degussa P-25 nano-TiO2 at varying doses for the optimization of treatment. Under the optimal dose of 250 mg/L of nano-TiO2, the complete removal of 2,4,6-trichlorophenol was observed within 210 min of the reaction period. The addition of H2O2 to further increase the rates of treatment did not yield any benefit. Under solar irradiation, almost 95% degradation of 2,4,6-trichlorophenol was observed in 315 min at an optimized photocatalyst dose. Moreover, the comparison of the operational cost of UV-photocatalysis (UV/nano-TiO2), photocatalysis with H2O2 (UV/nano-TiO2/H2O2) and solar-photocatalysis revealed costs of US$0.27 per litre, US$0.30 per litre and US$0.16 per litre, respectively, during the experimentation, thus making solar-photocatalysis the best option.
Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and
Lung in Male and Female Rats
Authors: Erdogan Teslime , Oguz Halis , Corum Orhan 
Published: January 2024

Background:
The simultaneous use of NSAIDs and antibiotics is recommended for bacterial dis-eases in human and veterinary medicine. Moxifloxacin (MFX) and dexketoprofen (DEX) can be used simul-taneously in bacterial infections. However, there are no studies on how the simultaneous use of DEX affects the pharmacokinetics of MFX in rats.

Objectives:
The aim of this study was to determine the effect of DEX on plasma and lung pharmacokinetics of MFX in male and female rats.

Methods:
A total of 132 rats were randomly divided into 2 groups: MFX (n=66, 33 males/33 females) and MFX+DEX (n=66, 33 females/33 males). MFX at a dose of 20 mg/kg and DEX at a dose of 25 mg/kg were administered intraperitoneally. Plasma and lung concentrations of MFX were determined using the high-performance liquid chromatography-UV and pharmacokinetic parameters were evaluated by non-compartmental analysis.

Results:
Simultaneous administration of DEX increased the plasma and lung area under the curve from 0 to 8 h (AUC0-8) and peak concentration (Cmax) of MFX in rats, while it significantly decreased the total body clearance (CL/F). When female and male rats were compared, significant differences were detected in AUC0-8, Cmax, CL/F and volume of distribution. The AUC0-8lung/AUC0-8plasma ratios of MFX were calculated as 1.68 and 1.65 in female rats and 5.15 and 4.90 in male rats after single and combined use, respectively.

Conclusion:
MFX was highly transferred to the lung tissue and this passage was remarkably higher in male rats. However, DEX administration increased the plasma concentration of MFX in both male and female rats but did not change its passage to the lung. However, there is a need for a more detailed investigation of the difference in the pharmacokinetics of MFX in male and female rats.
Analysis of the Expression of PRDX6 in Patients with Hepatocellular
Carcinoma and its Effect on the Phenotype of Hepatocellular Carcinoma
Cells
Authors: Mu Runhong , Chang Mingzhu , Feng Chuanbo , Cui Yunhe , Li Tingyu , Liu Chang , Wang Yilin , Guo Xiao 
Published: January 2024

Objective:
This research aimed to study the expression of PRDX6 mRNA in hepatocellular
carcinoma (HCC) and its effect on the prognosis of HCC. Moreover, the effect of PRDX6
gene knockdown on the proliferation, migration, and invasion of HepG2 cells mediated by lentivirus
was also examined. This study offers a theoretical and experimental basis for further research
on the mechanism of PRDX6 in liver cancer and new methods for clinical diagnosis and
treatment.

Methods:
RNA sequence data of 369 HCC patients were screened through the TCGA database,
and the expression and clinical characteristics of PRDX6 mRNA were analyzed based on high-
-throughput RNA sequencing data. HepG2 cells were divided into WT, sh-NC and sh-PRDX6
groups. Real-time PCR and Western blot were used to detect the expression levels of the PRDX6
gene and protein, respectively. CCK8 method was used to detect the proliferation activity of Hep-
G2 cells, scratch healing test was used to detect the migration ability, Transwell chamber was
used to detect the invasion ability, and Western blot was used to detect the expression levels of
PI3K/Akt/mTOR signaling pathway and Notch signaling pathway-related proteins.

Results:
The expression of PRDX6 was significantly correlated with the gender, race, clinical
stage, histological grade, and survival time of HCC patients (P < 0.05). Compared with that in
WT and sh-NC groups, the expression level of PRDX6 protein in HCC patients was significantly
lower (P < 0.01), the proliferation activity of HCC cells was significantly decreased (P < 0.05),
and the migration and invasion ability was significantly decreased (P < 0.05) in the sh-PRDX6
group. The expression levels of PI3K, p-Akt, p-mTOR, Notch1, and Hes1 proteins in the sh-
PRDX6 group were significantly lower than those in WT and sh-NC groups (P < 0.05).

Conclusion:
The expression of PRDX6 may be closely related to the prognosis of HCC. Lentivirus-
mediated PRDX6 knockdown can inhibit the proliferation, migration and invasion of HCC
cells, which may be related to its regulating the PI3K/Akt/mTOR and Notch1 signaling pathways.
PRDX6 is expected to be a new target for the diagnosis and treatment of liver cancer.
Deciphering Neuroprotective Effect of Rosmarinus officinalis L.
(syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies
Authors: Oresanya Ibukun O. , Orhan Ilkay E. 
Published: January 2024

Abstract:
Rosmarinus officinalis L. (RO, rosemary) is a well-known medicinal, aromatic, and
culinary herb with traditional use in European folk medicine against memory deficits and neurodegenerative
disorders.

:
This review highlights the different neuroprotective activities of RO investigated in both preclinical
and clinical studies, as well as in silico molecular docking of bioactive compounds found in
RO.

:
The neuroprotective effect of RO was searched through databases including PubMed, Web of Science
(WoS), Scopus, and Clinical Trials using the keywords “Rosmarinus officinalis, rosemary,
neuroprotective effect, memory, cognitive dysfunction, Alzheimer’s disease.”

:
RO, which is rich in secondary metabolites that have memory-enhancing potential, has displayed
neuroprotection through different molecular mechanisms such as inhibition of cholinesterase, modulation
of dopaminergic and oxytocinergic systems, mediation of oxidative and inflammatory proteins,
involved in neuropathic pain, among others. RO extracts exhibited antidepressant and anxiolytic
activities. Also, the plant has shown efficacy in scopolamine-, lipopolysaccharide-, AlCl3-,
and H2O2-induced amnesia as well as amyloid-beta- and ibotenic acid-induced neurotoxicity and
chronic constriction injury-related oxidative stress memory and cognitive impairments in animal
models. A few clinical studies available supported the neuroprotective effects of RO and its constituents.
However, more clinical studies are needed to confirm results from preclinical studies further
and should include not only placebo-controlled studies but also studies including positive controls
using approved drugs.

:
Many studies underlined that constituents of RO may have the potential for developing drug candidates
against Alzheimer’s disease that possess high bioavailability, low toxicity, and enhanced
penetration to CNS, as revealed from the experimental and molecular docking analysis.
Modeling the Antiviral Activity of Ginkgo biloba Polyphenols against
Variola: In Silico Exploration of Inhibitory Candidates for VarTMPK and
HssTMPK Enzymes
Authors: Sarra Hamdani , Salim Bouchentouf , Hocine Allali 
Published: January 2024

Background::
The aim of this study is to use modeling methods to estimate the antiviral
activity of natural molecules extracted from Ginkgo biloba for the treatment of variola which is a
zoonotic disease posing a growing threat to human survival. The recent spread of variola in nonendemic
countries and the possibility of its use as a bioterrorism weapon have made it a global
threat once again. Therefore, the search for new antiviral therapies with reduced side effects is necessary.

Methods::
In this study, we examined the interactions between polyphenolic compounds from Ginkgo
biloba, a plant known for its antiviral activity, and two enzymes involved in variola treatment,
VarTMPK and HssTMPK, using molecular docking.

Results::
The obtained docking scores showed that among the 152 selected polyphenolic compounds;
many ligands had high inhibitory potential according to the energy affinity. By considering
Lipinski’s rules, we found that Liquiritin and Olivil molecules are the best candidates to be developed
into drugs that inhibit VarTMPK because of their high obtained scores compared to reference
ligands, and zero violations of Lipinski’s rules. We also found that ginkgolic acids have good affinities
with HssTMPK and acceptable physicochemical properties to be developed into drugs administered
orally.

Conclusion::
Based on the obtained scores and Lipinski’s rules, Liquiritin, Olivil, and ginkgolic acids
molecules showed interesting results for both studied enzymes, indicating the existence of
promising and moderate activity of these polyphenols for the treatment of variola and for possible
multi-targeting. Liquiritin has been shown to exhibit anti-inflammatory effects on various inflammation-
related diseases such as skin injury, hepatic inflammatory injury, and rheumatoid arthritis.
Olivil has been shown to have antioxidant activity. Olivil derivatives have also been studied for
their potential use as anticancer agents. Ginkgolic acids have been shown to have antimicrobial and
antifungal properties. However, ginkgolic acids are also known to cause allergic reactions in some
people. Therefore, future studies should consider these results and explore the potential of these
compounds as antiviral agents. Further experimental studies in-vitro and in-vivo are required to validate
and scale up these findings.
Investigating the Antioxidant Capacity of Newly Synthesized Flavonoids
via DPPH Assay
Authors: Shah Umang , Patel Samir , Patel Mehul , Patel Sandip 
Published: January 2024

Background:
Numerous naturally occurring and artificially synthesized flavonoids have
garnered attention for their impressive ability to combat oxidative stress and scavenge free radicals
when evaluated in laboratory settings. The core aim of our investigation revolved around assessing
the antioxidant potential of a diverse range of synthesized flavonoids through in vitro experiments.

Method:
We crafted 29 distinct flavonoids using the aldol condensation mechanism via a chalcone
intermediate to accomplish this. We meticulously characterized these newly formed compounds using
a variety of spectroscopic techniques. We employed the widely recognized DPPH free radical
method for the crucial antioxidant evaluation, a benchmark in such studies.

Result:
The radical scavenging efficacy of our synthesized flavonoids was then meticulously compared
to that of the positive control, ascorbic acid, renowned for its antioxidant prowess, and the IC50
values for each compound were calculated and examined. Surprisingly, our results showed that the
flavonoids we tested had a wide range of antioxidant activity, with IC50 values that ranged from 75.8
± 8.30 to 397 ± 25.10 μg/mL.

Conclusion:
Intriguingly, compounds US5, US13, US16, US17, US18, and US21 outshone even
ascorbic acid in their antioxidant potential, displaying remarkable scavenging abilities against free
radicals. This discovery holds promise for further exploration of these compounds as potential antioxidants
with potential applications in health and wellness.
Exploring Scientific Validation of Millets in Contemporary Healthcare: A
Traditional Food Supplement
Authors: Singh Harjeet , Aalam Zubair , Baheti Sandip R , Chaudhary Anurag , Sharma Alok , Murthy S N 
Published: January 2024

Abstract:
Millets, small-seeded grasses, are gaining interest for their nutrition and health benefits.
This abstract provides a comprehensive overview of millets' pharmacological activities,
highlighting their rich bioactive compounds. These compounds, including phenolic compounds,
flavonoids, and dietary fibers, contribute to antioxidant effects, safeguarding against
chronic diseases. Millets also possess anti-inflammatory properties, potentially alleviating
conditions, like arthritis and asthma. They show anti-carcinogenic potential, possibly preventing
various cancers' development through mechanisms, like apoptosis induction and inhibiting
tumor growth. Moreover, millets offer hypolipidemic and hypoglycemic effects, beneficial for
managing conditions, such as dyslipidemia and diabetes. Their high dietary fiber and resistant
starch content regulate blood lipids and glucose, reducing the cardiovascular risk. Additionally,
millets act as antimicrobials, inhibiting pathogens and serving as natural alternatives to synthetic
antimicrobials. They exhibit immunomodulatory effects, enhancing immune function
and response. Overall, millets' pharmacological properties, including antioxidant, antiinflammatory,
anti-carcinogenic, hypolipidemic, hypoglycemic, antimicrobial, and immunomodulatory
traits, position them as functional foods with varied health benefits. Further research
can integrate millets into preventive and therapeutic approaches for diverse diseases.