bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in glutamate, arginine, and energy metabolism characterize cerebrospinal fluid and plasma metabolome of persons with HIV-associated dementia
Authors: Mastrangelo Andrea , Scotti Giulia Maria , Manteiga Jose Garcia , Gisslén Magnus , Price Richard W. , Bestetti Arabella , Turrini Filippo , Caccia Roberta , Gorelik Leonid , Morelli Marco J. , Castagna Antonella , Cinque Paola 
Published: October 2023

Objectives:
HIV-associated dementia (HAD) is the most severe clinical expression of HIV-mediated neuropathology, and the processes underlying its development remain poorly understood. We aimed to exploit high-dimensional metabolic profiling to gain insights into the pathological mechanisms associated to HAD.

Design:
In this cross-sectional study, we utilized metabolomics to profile matched cerebrospinal fluid (CSF) and plasma samples of HAD individuals (n = 20) compared with neurologically asymptomatic people with HIV (ASYM, n = 20) and healthy controls (NEG, n = 20).

Methods:
Identification of plasma and CSF metabolites was performed by liquid-chromatography or gas-chromatography following a validated experimental pipeline. The resulting metabolic profiles were analyzed by machine-learning algorithms, and altered pathways were identified by comparison with KEGG pathway database.

Results:
In CSF, HAD patients displayed an imbalance in glutamine/glutamate ratio, decreased levels of isocitrate and arginine, and increased oxidative stress when compared with ASYM or NEG. These changes were confirmed in matched plasma samples, which in addition revealed an accumulation of eicosanoids and unsaturated fatty acids in HAD individuals. Pathway analysis in both biological fluids suggested that alterations in several metabolic processes, including protein biosynthesis, glutamate and arginine metabolism, and energy metabolism, in association to a perturbed eicosanoid metabolism in plasma, may represent the metabolic signature associated to HAD.

Conclusion:
These findings show that HAD may be associated with metabolic modifications in CSF and plasma. These preliminary data may be useful to identify novel metabolic biomarkers and therapeutic targets in HIV-associated neurological impairment.
Response to immune checkpoint inhibition is associated with the gut microbiome in advanced KRAS-mutated non-small cell lung cancer
Authors: Hiddinga Birgitta I. , Bolte Laura A. , van der Leest Paul , Hijmering-Kappelle Lucie B.M. , van der Wekken Anthonie J. , Schuuring Ed , Gacesa Ranko , Hospers Geke A.P. , Weersma Rinse K. , Björk Johannes R. , Hiltermann T Jeroen N 
Published: October 2023

AbstractBackgroundKRAS-mutated non-small cell lung cancer (NSCLC) is associated with a poor prognosis to standard therapies. Despite advances of immune checkpoint inhibitors (ICIs), not all patients show durable responses. In this study, we aim to identify associations between ICI-response and the gut microbiome in patients with KRAS-mutated NSCLC.MethodsWe performed shotgun metagenomic sequencing of stool samples collected before ICI initiation from 33 patients with KRAS-mutated NSCLC. Microbiome composition within (α-diversity) and between samples (β-diversity) was calculated using Shannon diversity index and principal component analysis on Aitchison distances, respectively. A Bayesian logistic-normal regression model (Pibble) was implemented to identify associations between gut microbial features and disease control rate (DCR), progression free survival at 12 months (PFS12) and immune related adverse events (irAEs), adjusting for ICI-regimen, metastatic disease stage, age, sex and BMI.ResultsResponders were enriched with several saccharolytic species, includingAgathobaculum butyriciproducens, Fusicatenibacter saccharivorans, Bifidobacterium longumandEubacterium ramulus. Non-responders harbored higher abundances of several Bacteroides and Blautia species. Patients unaffected by irAEs demonstrated higher abundances of biotin and butyrate synthesis pathways. Development of irAEs was associated with higherAlistipes finegoldii, Bifidobacterium longumandBacteroides uniformisabundance. No differences were observed between responders and non-responders in Shannon diversity index (P=0.69) and overall microbial composition (P=0.82).ConclusionsWe show gut microbial species and pathways that are differentially abundant between responders and non-responders to ICI in the setting of KRAS-mutated NSCLC. We find overlap with microbial signatures of response to ICI in other tumor types, potentially reflecting tumor-independent microbial mechanisms.
Siderophore-Mediated Conveyance of Antibacterial-Antisense Oligomers
Authors: Pals Mathijs J. , Wijnberg Luuk , Yildiz Çağlar , Velema Willem A. 
Published: October 2023

AbstractAntibacterial resistance is a major threat for human health. There is a need for new antibacterials to stay ahead of constantly-evolving resistant bacteria. Antibiotic antisense oligomers hold promise as powerful next-generation antibiotics, but issues with their delivery hamper their applicability. Here, we exploit the siderophore-mediated iron uptake pathway to efficiently transport antisense oligomers into bacteria. We appended a synthetic siderophore to antisense oligomers targeting the essentialacpPgene in Escherichia coli. Siderophore-conjugated morpholino and PNA antisense oligomers displayed potent antibacterial properties. Conjugates bearing a minimal siderophore consisting of a mono-catechol group showed equally effective. Targeting thelacZtranscript resulted in dose-dependent decreased β-galactosidase production, demonstrating selective protein downregulation. Whole-genome sequencing of resistant mutants and competition experiments with the endogenous siderophore verified selective uptake through the siderophore-mediated iron uptake pathway. Lastly, no toxicity towards mammalian cells was found. Collectively, our work provides a convenient approach for delivering antisense oligomers into bacteria.
Environmental knowledge level and consumer behavior regarding green fashion: a moderated mediation model
Authors: Zhang Gaopeng , Wang Linfan , Meng Hu 
Published: October 2023

PurposeBased on the knowledge-attitude-behavior model, this study is aimed at investigating the influential mechanism underlying the purchase of green clothing by dividing this clothing category into green home-in wear and home-out wear within the context of green consumption. The mediating effects of perceived greenwashing (PG), perceived value (PV) and expected moral benefit (EMB) and the moderating effect of green clothing type (GCT) were examined.Design/methodology/approachThe data for this study were collected from 366 valid samples through a between-subject design survey administered in China. Moderation analysis and mediation analysis using SPSS/PROCESS macro were applied to test the proposed hypotheses.FindingsThe results indicate that consumers' level of environmental knowledge (EKL) not only has a direct effect on purchase intention (PI) but also has an indirect effect through perceived value and expected moral benefit. However, perceived greenwashing did not play a mediating role in this relationship.Originality/valueThe study's findings show a moderating effect of green clothing type (green home-in wear vs green home-out wear). That is, compared to green home-out wear, the relationship between expected moral benefit and perceived greenwashing for green home-in wear had a weaker negative effect on purchase intentions.
Ameliorating emergency Web-enabled teaching in higher education institutions and implications for future emergencies
Authors: Looi Kim Hoe 
Published: October 2023

Purpose
This study aims to investigate the contextual challenges of emergency Web-enabled teaching from instructors’ point of view and their future preference for online education.

Design/methodology/approach
A total of 165 instructors from various public and private universities and university colleges in Malaysia participated in this online survey. Data were analyzed using multiple regression.

Findings
The significant challenges for future preference for online education in terms of their relative importance were supporting learners, effectiveness, disadvantages and advantages of emergency Web-enabled teaching.

Originality/value
This study discusses theoretical, practical and public policy implications for the future of teaching in higher education due to the COVID-19 public health emergency.
The appreciation of the collaboration agreements used to prevent intrafamilial homicides
Authors: Christine Drouin , Jean-Martin Deslauriers , John Hamel , Tamsin Higgs 
Published: October 2023

Purpose
The purpose of this paper is to improve the understanding of how collaboration agreements function and their benefits for the environments where they are implemented. The goal of these initiatives is to bring together in partnerships the actors concerned by domestic violence and coordinate their actions to ensure the safety of persons at risk of intrafamilial homicides through an effective collaboration structure.

Design/methodology/approach
The synthesis data originates from four research projects research work with the partners of four studied agreements: A-GIR (Arrimage-Groupe d’Intervention Rapide [Rapid Intervention Unit]) in Laval, Alerte-Lanaudière [Lanaudière Alert] in the Lanaudière region, P.H.A.R.E. (Prévention des homicides intrafamiliaux par des Actions Rapides et Engagées [Domestic Homicide Prevention through Rapid and Committed Action]) in South Western Montérégie and the Rabaska Protocol in Abitibi-Témiscamingue.

Findings
Overall, the interveners agree on the positive impacts resulting from the relationships between the partners, the development of a common expertise and the collective responsibility acting to prevent intrafamilial homicides, while highlighting the challenges met and the essential conditions for the success of these collaboration initiatives.

Research limitations/implications
Findings are drawn from participants in a particular locale – i.e. French–Canada, and may not entirely apply to other regions and cultures. Additional research should be conducted with similar methodology in other regions of Canada and elsewhere.

Practical implications
The findings should help in the further development of best practices for IPH prevention and therefore protect potential victims from lethal assaults of domestic violence.

Originality/value
Few studies have been conducted on how stakeholders involved in IPH prevention actually work together in collaborative efforts, and none, as far as we know, specifically on drawing up formal agreements.
Commitment, trust, relative dependence, and customer loyalty in the B2B setting: the role of customer satisfaction
Authors: Arthur Emmanuel , Agbemabiese George Cudjoe , Amoako George Kofi , Anim Patrick Amfo 
Published: October 2023

Purpose
This study aims to explore the role customer satisfaction play in mediating the nexus between commitment, trust, relative dependence and customer loyalty from an emerging market context under a business-to-business (B2B) setting.

Design/methodology/approach
The study was a descriptive survey, and using convenience sampling technique, questionnaires were used to gather data from 356 businesses that were distributors of Guinness Ghana Company Limited. Partial least squares structural equation modeling was used to test the proposed hypotheses for this study, and macro-PROCESS was performed to test the mediating effect of customer satisfaction.

Findings
The findings show that relative dependence had the most considerable significant and positive impact on B2B partners satisfaction, followed by commitment and trust, respectively. A positive and significant relationship was also found between B2B firms’ satisfaction and loyalty. The result also indicates that customer satisfaction mediates the relationship between commitment, trust, relative dependence and B2B loyalty.

Practical implications
Practitioners can manipulate specific relative dependence, commitment and trust features to increase customer satisfaction with their firm’s services, thus ensuring longer-term customer loyalty.

Originality/value
Drawing on the social exchange theory, this study provides a more profound perspective focusing on an emerging market context, by examining from a B2B setting the significance of commitment, trust, relative dependence and B2B partners satisfaction on loyalty.
Legal framework of sustainable construction procurement to prevent land degradation: comparison between Indonesia, Singapore and Thailand
Authors: Kurniawan Faizal , Nugraha Xavier , Hartono Julienna , Wibisono Angelica Milano Aryani 
Published: October 2023

Purpose
This paper aims to analyze regulation regarding sustainable construction procurement in Southeast Asia and provide a reconstruction of regulation regarding the sustainable construction procurement to prevent land degradation.

Design/methodology/approach
This was done through legal research methods, mainly historical and systematical interpretation. The approaches used in this paper are the conceptual approach, statute approach and comparative approach.

Findings
By analyzing the related legal norms, it can be understood that many nations in Southeast Asia do not have regulation regarding sustainable construction procurement. Between Indonesia, Singapore and Thailand, only Indonesia has a ministrial regulation that provides general norms regarding sustainable construction procurement. Regarding the reconstruction of regulation, the bare minimum standards consist of principle, indicators, pillar, the phases of the procurement, law enforcement, both preventive and repressive, and sustainable procurement committee.

Research limitations/implications
This research is limited to regulation in Southeast Asian region. By analyzing the regulation, this paper will provide a reconstruction of regulations regarding sustainable construction procurement that will act as an ground rules. Having the same ground rules will create synergies between countries in Southeast Asia to apply the principles of sustainable procurement and move together toward to prevent land degradation.

Originality/value
To the best of the authors’ knowledge, this paper is the first systematic legal research that compares regulations from three nations in Southeast Asia regarding sustainable construction procurement and also the first paper to provide reconstruction of regulation regarding sustainable construction procurement to prevent land degradation.
Valuation, compensation and rehabilitation for expropriation and its impact on the expropriated households in Ethiopia: evidence from Debre Markos city
Authors: Aschale Embial Asmamaw , Asres Habtamu Bishaw 
Published: October 2023

PurposeThe purpose of this paper is to examine expropriation, valuation, compensation and rehabilitation practices and their impacts on expropriated households.Design/methodology/approachThis study employed a mixed research approach. The target populations of the study were expropriated households in Debre Markos City from 2019 to 2022. The study uses purposive and systematic random sampling techniques. The data were analyzed using descriptive statistics, narration and thematic clustering.FindingsThe findings of this study revealed that the expropriation process was not participatory and the right holders were not treated as what is expected. It is further found that economic losses, moral damage and social disturbance payments were not considered in the compensation package. The displacement compensation given was also inadequate and sometimes delayed and the time value of money was not taken into account for delayed payments. This creates social and economic problems. The rehabilitation and resettlement program was inadequate and ineffective. The expropriation, valuation, compensation and rehabilitation practice in general lack transparency and accountability.Practical implicationsTo ensure efficient and effective expropriation, valuation and compensation, there should be a well-organized government system that provides an accurate valuation on the one hand and restores the livelihood of the displaced on the other.Originality/valueThis paper is the first on expropriation, valuation, compensation and rehabilitation within the framework of transparency, accountability, effective rehabilitation and resettlement and institutional arrangements to ensure the sustainable livelihoods of affected households.
A novel multi-layer feature fusion-based BERT-CNN for sentence representation learning and classification
Authors: Alyoubi Khaled Hamed , Alotaibi Fahd Saleh , Kumar Akhil , Gupta Vishal , Sharma Akashdeep 
Published: October 2023

Purpose
The purpose of this paper is to describe a new approach to sentence representation learning leading to text classification using Bidirectional Encoder Representations from Transformers (BERT) embeddings. This work proposes a novel BERT-convolutional neural network (CNN)-based model for sentence representation learning and text classification. The proposed model can be used by industries that work in the area of classification of similarity scores between the texts and sentiments and opinion analysis.

Design/methodology/approach
The approach developed is based on the use of the BERT model to provide distinct features from its transformer encoder layers to the CNNs to achieve multi-layer feature fusion. To achieve multi-layer feature fusion, the distinct feature vectors of the last three layers of the BERT are passed to three separate CNN layers to generate a rich feature representation that can be used for extracting the keywords in the sentences. For sentence representation learning and text classification, the proposed model is trained and tested on the Stanford Sentiment Treebank-2 (SST-2) data set for sentiment analysis and the Quora Question Pair (QQP) data set for sentence classification. To obtain benchmark results, a selective training approach has been applied with the proposed model.

Findings
On the SST-2 data set, the proposed model achieved an accuracy of 92.90%, whereas, on the QQP data set, it achieved an accuracy of 91.51%. For other evaluation metrics such as precision, recall and F1 Score, the results obtained are overwhelming. The results with the proposed model are 1.17%–1.2% better as compared to the original BERT model on the SST-2 and QQP data sets.

Originality/value
The novelty of the proposed model lies in the multi-layer feature fusion between the last three layers of the BERT model with CNN layers and the selective training approach based on gated pruning to achieve benchmark results.
City walk in a gap day: potential and opportunities for tourism and leisure
Authors: Wu Dongdong 
Published: October 2023

Purpose
To the best of the author's knowledge, this study, among the first of its kind, aims to offer a preliminary exploration of the “city walk” travel model in the context of China.

Design/methodology/approach
By conducting phenomenological research, it endeavors to comprehend the motivations driving individuals to engage in “city walk” activities through the lens of social psychology, specifically focusing on labeling theory.

Findings
The immersive “city walk” establishes a deeper connection with the urban environment. Participants attach greater significance to their travel experiences, seeking a profound understanding of the city and its way of life, thus pursuing the essence of tourism and leisure.

Originality/value
This study outlines potential opportunities and future prospects for the “city walk” concept within the cultural tourism industry.
Increased risk of sleep disturbances in patients with rosacea: A nationwide population‐based cohort study
Authors: Chae Kyunghee , Cho Minah , Kim Sukil , Woo Yu Ri 
Published: October 2023

AbstractRosacea is a chronic inflammatory skin disorder linked to various mental disorders, but little is known about the impact of rosacea on sleep disorders. The aim of this study is to confirm the association of rosacea with sleep disorders using a large administrative data set. This nationwide population‐based retrospective cohort study enrolled 1129 individuals with rosacea and 11 017 age‐ and sex‐matched controls without rosacea from the Korean National Health Insurance System database from 2002 to 2015. The prevalence of sleep disorder (7.8%) was significantly higher in patients with rosacea than in controls (5.81%; p < 0.001). Rosacea was associated with an increased risk of sleep disorder (adjusted odds ratio [aOR], 1.287 [95% confidence interval (CI), 1.022–1.623]). Among a variety of sleep disorders, patients with rosacea were likely to have an increased risk of insomnia (aOR, 1.318 [95% CI, 1.002–1.743]). In subgroup analysis, female patients with rosacea (aOR, 1.297 [95% CI, 1.010–1.722]) and those with rosacea and dyslipidemia (aOR, 1.417 [95% CI, 1.062–1.891]) were at a higher risk of having a sleep disorder. Rosacea is associated with an increased risk of having sleep disorders. The management of modifiable risk factors is important for managing sleep disorders in patients with rosacea.
Environmental filtering of life‐history trait diversity in urban populations of Arabidopsis thaliana
Authors: Schmitz Gregor , Linstädter Anja , Frank Anke S. K. , Dittberner Hannes , Thome Jessica , Schrader Andrea , Linne von Berg Karl‐Heinz , Fulgione Andrea , Coupland George , de Meaux Juliette 
Published: October 2023

Abstract

The challenges to which plants are exposed in urban environments represent, in miniature, the challenges plants face as a result of global environmental change. Hence, urban habitats provide a unique opportunity to assess whether processes of local adaptation are taking place despite the short temporal and geographical scales that characterize the Anthropocene.

We quantified the ecological diversity of urban habitats hosting Arabidopsis thaliana populations. Using plant community indicators, we show that these patches differ in their levels of soil nutrient content and disturbance. Accordingly, plants in each patch displayed a range of flowering time, size and fitness.

Using a deep sampling approach coupled with reduced genome sequencing, we demonstrate that most individuals can be assigned to a limited set of clonal lineages; the genetic diversity of these lineages is a sample of the diversity observed in western European populations of the species, indicating that established urban populations originate from a broad regional pool of lineages.

We assessed the genetic and phenotypic diversity of these lineages in a set of common garden experiments. We report marked genetic differences in life‐history traits, including time of primary and secondary dormancy as well as of flowering. These genetic differences in life‐history traits are not randomly distributed but sorted out by ecological differences among sites of origin.

Synthesis. Our study shows that the genetically diverse phenology of a regional Arabidopsis thaliana gene pool is not randomly distributed but filtered by heterogeneity in the urban environment. To our knowledge, this report is the first to show a pattern indicative of environmental filtering enhancing local genetic adaptation within urban environments. We conclude that environmental filtering helps maintain functional diversity within species.