bluuebunny/crossref_metadata_2025_split huggingface dataset:
19-Year Follow-up on Patients with Axenfeld-Rieger Anomaly or Syndrome and Fuchsʼ Endothelial Dystrophy Including the 6th Generation in a Pedigree
Authors: Schuknecht Angelika , Wachtl Josephine , Baumer Alessandra , Kniestedt Christoph 
Published: January 2025

Abstract
Background Nineteen-year follow-up after initial examination on patients with Axenfeld-Rieger anomaly or syndrome (ARAS) and coexisting Fuchsʼ endothelial dystrophy (FED). All individuals had previously been tested positive for the PITX2 (g.20 913 G>T) mutation. Additionally, we addressed their descendants for phenotype and genotype examination to determine their penetrance into the next generations.
Patients and Methods Twenty-nine patients (9 patients and 20 of their descendants) participated in this prospective observational study. Nine patients were examined and tested positive for the PITX variant (g.20 913 G>T) in our previous study in 2001. Fourteen descendants were genetically and clinically examined. Six descendants were not available for clinical examination but donated saliva samples for genetic analysis. Ophthalmic examination was performed, consisting of visual acuity (VA) testing, applanation tonometry, gonioscopy, and anterior segment and central fundus biomicroscopy. Peripapillary optical coherence tomography (pOCT) was performed, and endothelial cell density (ECD) and central corneal thickness (CCT) were measured. Clinical disease progression in patients with a positive PITX2 mutation, genetic defect transmission, and clinical penetrance in subsequent third to sixth generations were the main outcome measures.
Results Ten out of twenty descendants tested positive for the PITX2 variant (g.20 913 G>T). Eight were identified as being affected by ARAS. FED was found in six patients. All of them showed ARAS. Third generation patients (mean age 82) progressed significantly in both coexisting diseases. Four of six eyes ended up in corneal edema, with VA below 0.2. Glaucoma assessment was compromised due to corneal edema. Fourth generation patients (mean age 43) showed a mean CCT of 611 µm, ECD of 1230, and intraocular pressure (IOP) of 17.5 mmHg and thinning of the peripapillary nerve fiber layer. One eye was newly diagnosed with glaucoma, elevated IOP, and mild corneal edema. Fifth generation patients (mean age 27) presented with a mean CCT of 564 µm, ECD of 2802, and IOP of 14.4 mmHg.
Conclusion Genetic analysis confirmed the PITX2 (g.20 913 G>T) mutation was associated with Axenfeld-Rieger and FED in 10 of 20 descendants in this family. This matches the autosomal dominant inheritance pattern with a probability of 50%. Glaucoma and corneal decompensation were progressive over 19 years, with variable expression and early onset in subsequent pedigree members.
Introduction of Patient-reported Outcome Measures in a Cardiac Surgery Center
Authors: Bilger Selina , Koechlin Luca , Gahl Brigitta , Miazza Jules , Vöhringer Luise , Berdajs Denis , Rüter Florian , Reuthebuch Oliver 
Published: January 2025

Background Although patient-reported outcome measures (PROMs) as an integral part of value-based healthcare have important potential for clinical issues, e.g., for shared decision-making, data are limited. Thus, the aim of this study was to report initial results when introducing PROMs in the setting of cardiac surgery.
Methods Patients undergoing elective coronary artery bypass grafting (CABG) were included. Three questionnaires (Seattle Angina Questionnaire 7 [SAQ-7], Rose Dyspnea Scale [RDS], and Patient Health Questionnaire 2 [PHQ-2]) were either administered via iPad (in-hospital) or via a web-based tool (at home). Baseline PROMs were completed at admission. Follow-ups were conducted at 30 days, 1 year, and 2 years postoperatively. We investigated the probability of improvement using multilevel, mixed-effects, ordered logistic regression.
Results Overall, 99 patients answered the questionnaires preoperatively, 84 of whom answered at least one questionnaire postoperatively. No patient died within the hospitalization. Median (IQR) length of stay in the intensive care unit (ICU) was 1.0 (1.0 to 2.0) days. In all dimensions of any PROMs questionnaire, OR was above 1, indicating that most patients reported improvement 1 to 2 years after surgery by at least 1 grade. In the exploratory analysis we found age ≥75 years positively associated with a significantly greater improvement of the SAQ-7 angina frequency and SAQ-7 quality of life score. Length of stay in the ICU showed no significant association with any PROMs at midterm follow-up.
Conclusion In patients undergoing CABG, after a decline within 30 days postoperatively, quality of life–related outcomes improved markedly in a midterm follow-up compared with the preoperative state.
Aplicações dos biotecidos na cirurgia plástica: Uma revisão sistemática
Authors: Araújo Rafael Silva de , Mussalem Matheus Galvão Valadares Bertolini , Silva Nicole Tortoro , Garcia Elvio Bueno , Ferreira Lydia Masako 
Published: January 2025

Resumo
Introdução Biotecidos são combinações organizadas de substâncias sintéticas e/ou biológicas que interagem com sistemas biológicos complexos para tratar, substituir ou remodelar tecidos ou órgãos. A bioengenharia de tecidos emprega diversos métodos, incluindo scaffolds biológicos e sintéticos, com interação com células-tronco e citocinas. Esta revisão examina técnicas e métodos para a síntese de biotecidos, além de sua eficácia em modelos animais e humanos.
Materiais e Métodos Foi realizada uma revisão sistematizada da literatura nas plataformas PubMed, Lilacs, Scielo e Cochrane, utilizando descritores específicos. A análise focou na identificação dos países de origem dos estudos, categorização das técnicas e recursos empregados, visando auxiliar na escolha de estratégias para o uso de biotecidos na cirurgia plástica reconstrutiva.
Resultados Dos 37 artigos selecionados, 15 abordaram experimentação in vitro, 14 in vivo, e 8 utilizaram ambas as abordagens. Os estudos foram classificados em 3 subtemas principais: adipogênese (18 artigos), angiogênese (10 artigos) e condrogênese (nove artigos), todos voltados para reconstruções teciduais.
Conclusão Os avanços no uso de biomateriais na medicina regenerativa são promissores, com experimentos satisfatórios alinhados à cirurgia plástica contemporânea. Embora a aplicação em humanos seja limitada, o potencial das células-tronco e fatores de crescimento sugerem avanços significativos que devem ser melhor desenvolvidos isoladamente em estudos futuros. Esta revisão esclarece as tecnologias e progressos no uso de biomateriais, destacando seu impacto na evolução técnica da cirurgia plástica reconstrutiva.
Retalho anterolateral da coxa para o tratamento de sequelas da angina de Ludwig: Relato de caso
Authors: Veloso Olga Lanusa Leite , Silva Diego Arley Gomes da , Lima Felipe Mazza de , Silva Kariny Oliveira , Pinho Pessoa Breno Bezerra Gomes de , Menezes Júnior José Maria Sampaio de 
Published: January 2025

ResumoA angina de Ludwig é um processo infeccioso polimicrobiano, geralmente de origem odontogênica, que requer diagnóstico e tratamento precoces, e é agravada por doenças sistêmicas. Procedimentos cirúrgicos podem ser necessários, como desbridamento e criação de retalhos para reconstrução. O retalho anterolateral da coxa é um retalho livre com inúmeras vantagens, como grande área doadora e sequelas funcionais mínimas. O objetivo deste artigo é relatar um caso de angina de Ludwig grave em que um retalho anterolateral da coxa foi utilizado para tratar as sequelas.
Complicações não habituais da cirurgia plástica de abdome que causam dor pós-operatória de diagnóstico difícil: Uma revisão integrativa
Authors: Pires Samara Tessari , Rosseto Marcelo 
Published: January 2025

Resumo
Introdução A cirurgia plástica abdominal está sujeita a complicações comuns, como hematoma, seroma e deiscência de suturas, a complicações graves, como sepse e tromboembolismo, e a complicações não habituais, como síndrome de quebra-nozes, pioderma gangrenoso, hérnia de hiato e distonia da motricidade do esôfago, que podem causar dor de diagnóstico difícil no pós-operatório, o que leva o cirurgião e a sua equipe a inúmeros diagnósticos por vezes não coincidentes com a patologia devido à raridade dos casos.
Materiais e Métodos Foi realizada uma revisão integrativa dos casos das complicações não habituais da cirurgia plástica de abdome relatados nas bases de dados PubMed/MEDLINE e LILACS, e os achados foram comparados com a casuística de um dos autores (MR) nos últimos 30 anos.
Resultados Não foram encontrados artigos de casos de síndrome de quebra-nozes e de distonia da motricidade do esôfago associados à abdominoplastia nas bases de dados. Foram encontrados nove casos de pioderma gangrenoso e três casos de hérnia de hiato. Na casuística de um dos autores (MR), havia um caso de cada uma das complicações, os quais foram comparados com os casos encontrados na literatura.
Conclusão As complicações não habituais da abdominoplastia influenciam a recuperação pós-operatória do paciente e podem dar origem à dor associada a outros sinais e sintomas de diagnóstico difícil.
Reduced resistance at molecular-crystal electrolyte and LiCoO2 interfaces for high-performance solid-state lithium batteries
Authors: Watanabe Yuki , Kobayashi Shigeru , Ruijie Zheng , Jun Deng , Tanaka Kenjiro , Nishio Kazunori , Nakayama Ryo , Shimizu Ryota , Moriya Makoto , Hitosugi Taro 
Published: January 2025

Molecular crystal electrolytes are promising solid electrolytes owing to their ionic conductivity and mechanical flexibility. However, solid-state batteries using these electrolytes suffer from the large resistance at the interfaces with positive electrodes. Herein, we fabricate a battery using Li{N(SO2F)2}(NCCH2CH2CN)2, referred to as Li(FSA)(SN)2, a molecular-crystal electrolyte, and demonstrate the stable thin-film battery cycling. The novel fabrication method forms electrochemically stable interfaces, allowing the thin-film batteries to cycle at a current density of up to 500 μA cm−2 in the voltage range of 3.00–4.05 V vs Li/Li+. This current density is 500 times higher than that reported previously. Notably, the Li(FSA)(SN)2–LiCoO2 interface resistance (24 Ω cm2) is comparable to that of the interface of liquid-electrolyte and LiCoO2 in Li-ion batteries. Furthermore, inserting an amorphous Li3PO4 layer into the Li(FSA)(SN)2–LiCoO2 interface enables stable cycling up to 4.30 V vs Li/Li+, suppressing the decomposition of electrolytes. These quantitative investigations and interfacial controls pave the way for the practical applications of molecular-crystal electrolytes to solid-state batteries.
A primer on Carroll gravity
Authors: March Eleanor , Read James 
Published: January 2025

Abstract
The ultra-relativistic limit of general relativity is Carroll gravity. In this article, we provide (i) a rigorous and thorough exposition of the geometric formalism of the ‘magnetic’ version of Carroll gravity, (ii) a presentation of this theory as a limit of general relativity in a geometrical, ‘lightcone-narrowing’ sense, and (iii) an exploration of some of the various conceptually interesting features of this version of Carroll gravity.
Potential effects of statistical complexity measure in improving the fault diagnosis performance under speed fluctuations
Authors: Sowmya S , Saimurugan M , Kannan N , Edinbarough Immanuel 
Published: January 2025

Abstract
Many research studies have been performed to extract non-stationary signal properties, such as the instantaneous frequency (IF) and envelope, to diagnose machinery faults under time-varying speed conditions. However, accurate IF extraction is difficult from such complex fluctuating signals to identify faults efficiently. Therefore, this paper proposes the statistical complexity measure (SCM) as a feature that evaluates the randomness and complexity without any additional requirement, providing an outstanding result in multi-component fault detection under speed fluctuations. Primarily, the influence of SCM is proved by ranking the features with the help of the random forest algorithm. The fault classification of individual signal characteristics confirms its ranking order as well. Then, it is targeted toward the efficacy of the signal fusion approach in multi-component fault diagnosis. Focusing on the essence of SCM, it is merged with the other three signal properties based on the ranking technique to investigate which one of the feature compositions is more advantageous. The machine learning classifier, SVM-RBF, achieves 94.7%, which proves the potential effects of SCM features in industrial rotational machinery components under variable speed conditions.
Interactive segmentation for accurately isolating metastatic lesions from low-resolution, large-size bone scintigrams
Authors: Ma Xiaoqiang , Lin Qiang , Zeng Xianwu , Cao Yongchun , Man Zhengxing , Liu Caihong , Huang Xiaodi 
Published: January 2025

Abstract

Objective. Bone is a common site for the metastasis of malignant tumors, and single photon emission computed tomography (SPECT) is widely used to detect these metastases. Accurate delineation of metastatic bone lesions in SPECT images is essential for developing treatment plans. However, current clinical practices rely on manual delineation by physicians, which is prone to variability and subjective interpretation. While computer-aided diagnosis systems have the potential to improve diagnostic efficiency, fully automated segmentation approaches frequently suffer from high false positive rates, limiting their clinical utility. Approach. This study proposes an interactive segmentation framework for SPECT images, leveraging the deep convolutional neural networks to enhance segmentation accuracy. The proposed framework incorporates a U-shaped backbone network that effectively addresses inter-patient variability, along with an interactive attention module that enhances feature extraction in densely packed bone regions. Main results. Extensive experiments using clinical data validate the effectiveness of the proposed framework. Furthermore, a prototype tool was developed based on this framework to assist in the clinical segmentation of metastatic bone lesions and to support the creation of a large-scale dataset for bone metastasis segmentation. Significance. In this study, we proposed an interactive segmentation framework for metastatic lesions in bone scintigraphy to address the challenging task of labeling low-resolution, large-size SPECT bone scans. The experimental results show that the model can effectively segment the bone metastases of lung cancer interactively. In addition, the prototype tool developed based on the model has certain clinical application value.
Introduction of a 3D global non-linear full-f particle-in-cell model for runaway electrons in JOREK
Authors: Bergström Hannes , Liu Shi-Jie , Bandaru Vinodh , Hoelzl Matthias ,   JOREK Team,   JET Contributors
Published: January 2025

Abstract
Disruptions present one of the leading concerns for reliable tokamak operation. The acceleration of electrons from the thermal bulk to relativistic energies, so-called runaway electron (RE) generation, is in particular a problem for future high current machines such as ITER. Accurately predicting the generation and impact of REs is therefore essential for making informed decisions concerning machine design and the use of disruption mitigation systems. This requires high-fidelity modeling also accounting for the large MHD activity observed throughout disruptions, which is made especially difficult by the mutual coupling between REs and the companion plasma. The non-linear 3D extended MHD code JOREK is a powerful tool for studying disruption and RE physics. This work details recent developments in JOREK, introducing a hybrid fluid-kinetic model where the REs are modeled kinetically and coupled to the non-linear MHD equations using a full-f particle-in-cell approach. The model goes beyond the state of the art and can accurately capture phase space distributions and dynamics of REs, drift orbits, and transport and losses caused by stochastic fields. Benchmarks are presented for both 2D and 3D configurations, concerning the impact of REs on the force balance and linear tearing mode growth rates, where a good agreement with analytically derived results is found. In addition, a demonstration of a particularly complicated non-linear application with high relevance to large machines is made, namely a RE benign termination linked to a violent burst of MHD activity.
Opening measurement of rubber gaskets in tunnel segmental joints based on impedance analysis using piezoelectric sensors
Authors: Jiang Guodong , Zhang Guozhu , Cui Haoran 
Published: January 2025

Abstract
The segmental joint with rubber gaskets is the weakest part of the shield tunnel structure. Poor assembly quality or prolonged loading conditions can compromise the effectiveness of these gaskets, leading to issues such as leakage, seepage, and reduced load-bearing capacity. Currently, there is a lack of effective methods for directly monitoring the state of rubber sealing gaskets. This paper proposes a novel monitoring method for tunnel joint rubber sealing gaskets by integrating flexible piezoelectric sensors (PVDF) with rubber sealing gaskets, based on the principle of structural impedance analysis. First, the mechanical performance equation of the rubber sealing gasket is derived, and a piezoelectric material-rubber sealing gasket impedance model is proposed based on existing research. Subsequently, experiments are conducted on single-set rubber sealing gaskets using piezoelectric impedance analysis, as well as on dual-set rubber sealing gaskets in both series and parallel configurations. The impedance magnitude, phase angle, real part, and imaginary part of the impedance are analyzed to evaluate the performance of the proposed method. The results demonstrate that the impedance magnitude, phase angle, and real part of the impedance of the piezoelectric sensor-rubber sealing gasket structure can effectively reflect the opening state of the rubber sealing gaskets. For the rubber sealing gaskets selected in this study, for every 1 mm of opening, when the applied AC frequency is near the resonant frequency, the impedance magnitude increases by 0.23 Ω, the real part of the impedance increases by 0.3 Ω, and the phase angle decreases by 0.42° at an AC frequency of 300 MHz. In multi-set rubber sealing gasket simultaneous monitoring, the monitoring performance with series-connected internal sensors is found to be superior to that with parallel connections. When both sets of rubber sealing gaskets open simultaneously, compared to a single set of gaskets opening, the impedance magnitude curve generates an additional extreme point near the resonant frequency. This additional extreme point can serve as a signal to determine the opening of multiple sets of rubber sealing gaskets.
Pitfalls and practical suggestions for using local field potential recordings in DBS clinical practice and research
Authors: Swinnen Bart E K S , Buijink Arthur W G , Stam Mariëlle J , Hubers Deborah , de Neeling Martijn , Keulen Bart J , Morgante Francesca , van Wijk Bernadette C M , de Bie Rob M A , Ricciardi Lucia , Little Simon J , Beudel Martijn 
Published: January 2025

Abstract

Objective. Local field potential (LFP) recordings using chronically implanted sensing-enabled stimulators are a powerful tool for indexing symptom presence and severity in neurological and neuropsychiatric disorders, and for enhancing our neurophysiological understanding of brain processes. LFPs have gained interest as input signals for closed-loop deep brain stimulation (DBS) and can be used to inform DBS parameter selection. LFP recordings using chronically implanted sensing-enabled stimulators have various implementational challenges. Approach. Here we describe our collective experience using BrainSense (Medtronic®) for clinical and research work. We aim to provide insightful tips and practical advice to empower readers with the knowledge needed to navigate the intricacies of the device and make the most out of its features. Main results. The central issues that apply to several BrainSense features encompass restricted compatibility of stimulation configuration with sensing, differences in electrophysiological signal properties between ‘stimulation OFF’ and ‘stimulation ON at 0.0 mA’, and challenges associated with the internal clock of the neurostimulator. In addition, since recordings are obtained from bipolar and not monopolar channels, spatial certainty regarding the distribution of LFPs around the DBS electrode is limited. Several options exist to synchronize LFP time series with external data streams, but standardization and generalization are lacking. The use of at-home chronic LFP recording is limited by a low temporal and spectral resolution. Regarding at-home LFP snapshots, LFP time series are not stored, parts of the power spectrum are censored when stimulating at high or low frequencies, and the stimulation amplitude is not readily available. Significance. We discussed practical applications, implementation, system limitations, and pitfalls with the aim that sensing can be better applied for clinical practice and research.
Improving pre-movement patterns detection with multi-dimensional EEG features for readiness potential decrease
Authors: Zhang Lipeng , Zhang Hongyu , Yan Shaoting , Li Ruiqi , Yao Dezhong , Hu Yuxia , Zhang Rui 
Published: January 2025

Abstract

Objective. The readiness potential (RP) is an important neural characteristic in motor preparation-based brain–computer interface. In our previous research, we observed a significant decrease of the RP amplitude in some cases, which severely affects the pre-movement patterns detection. In this paper, we aimed to improve the accuracy (Acc) of pre-movement patterns detection in the condition of RP decrease. Approach. We analyzed multi-dimensional EEG features in terms of time–frequency, brain networks, and cross-frequency coupling (CFC). And, a multi-dimensional Electroencephalogram feature combination (MEFC) algorithm was proposed. The features used include: (1) waveforms of the RP; (2) energy in alpha and beta bands; (3) brain network in alpha and beta bands; and (4) CFC value between 2 and 10 Hz. Main results. By employing support vector machines, the MEFC method achieved an average recognition rate of 88.9% and 85.5% under normal and RP decrease conditions, respectively. Compared to classical algorithm, the average Acc for both tasks improved by 7.8% and 8.8% respectively. Significance. This method can effectively improve the Acc of pre-movement patterns decoding in the condition of RP decrease.