bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social connectedness in older adults: The potential of social internet use to maintain a strong and stable personal network
Authors: Janssen Jeroen H M , van Tilburg Theo G , van Ingen Erik J , Corten Rense , Peeters G M E E (Geeske) 
Published: January 2025

Abstract

Objective
Maintaining a strong social network in later life can be challenging due to limited resources, life events, and changes in health. Social internet use provides an accessible way for communication that is less susceptible to age-related challenges. Although social internet use is increasingly used by older adults, we do not know how social internet use shapes older adults’ offline networks. The purpose of this study is to examine whether social internet use can help maintain strong social relationships.

Methods
We used data from three waves (2012-2013, 2015-2016, and 2018-2019) of the Longitudinal Aging Study Amsterdam. Our sample included 2,266 older adults aged 55-99 (mean = 68.2 years, 54% female). We included the frequency of social internet use and computed personal network size, contact frequency, and the number of continued, gained, and lost ties over time. Hybrid models were applied to disentangle between within- and between-person associations.

Results
More frequent social internet users had significantly larger personal networks and, relative to the previous wave, more continued and gained network ties, compared to less frequent social internet users. A within-person increase in social internet use over time was associated with more continued and gained ties.

Discussion
Social internet use may help maintain a strong and stable network, which is important for social connectedness in later life. It allows for additional interaction opportunities, as well as network maintenance and growth. Social internet use thus proves to be a valuable addition to the social interaction resources of older adults.
The 2023 Mw 6.9 Sarez, Tajikistan earthquake: subparallel faulting and distributed deformation of the Pamir
Authors: Huang Xing , Jolivet Romain , Li Yanchuan , Shan Xinjian , Raimbault Bryan 
Published: January 2025

SUMMARY
The central Pamir plateau moves northward and collides into Eurasia at a rate that varies significantly over its 600-km-wide extension. However, the active structures accounting for such internal shear strain remain enigmatic. In this study, we use Interferometric Synthetic Aperture Radar (InSAR) data to investigate the coseismic and post-seismic deformation of the ${M}_{\rm w}\,6.9$ Sarez earthquake on 23 February 2023. Using a Bayesian framework, we find the most likely seismogenic fault geometry and explore the full solution space of slip distributions. Our results highlight the main shock ruptures a nearly NNE fault dipping to the southeast. The finite-fault model exhibits a purely left-lateral strike-slip mechanism with little to no slip reaching the surface. Most of the coseismic slip remains confined to a depth of ∼5 to 20 km, consistent with a large shallow slip deficit. Post-seismic afterslip, which decays rapidly within the month following the main shock, cannot compensate for such coseismic shallow slip deficit. Integrating the analysis of coseismic slip, post-seismic deformation and regional seismic activity, we argue that in the central Pamir, significant north–south shear strain is accommodated along multiple parallel faults, often unmapped, hence posing a significant seismic hazard.
Higher than expected telemedicine use by racial and ethnic minority and cognitively impaired Medicare beneficiaries
Authors: Cui Manying (Mandy) , Leng Mei , Arbanas Julia , Romanov Artem , Tseng Chi-Hong , Wei Melissa Y , Damberg Cheryl L , Harawa Nina , Mafi John N , Sarkisian Catherine 
Published: January 2025

Abstract
Although pandemic-era telemedicine flexibilities may have preserved access to care, concerns remain that telemedicine may have been inequitably distributed among older adults, especially those with mild cognitive impairment or dementia (MCID). As telemedicine flexibilities are set to fully expire on December 31, 2024, we aimed to examine pandemic-era and future-intended telemedicine use among older Americans to help inform post-pandemic telemedicine policy design. We hypothesized that telemedicine would be disproportionately underutilized among older adults with MCID or with racial and ethnic minority status. We used nationally representative survey data from the Health and Retirement Study and analyzed pandemic-era and future-intended telemedicine use among 10 075 Medicare beneficiaries aged &gt;50 years during 2020–2022 by cognition across beneficiaries-level characteristics such as age, gender, insurance status, education, and multimorbidity. Results were adjusted by survey weights and nonresponse rates for national representativeness. Contrary to our hypothesis, compared with White Medicare beneficiaries, Hispanic and Black beneficiaries with normal cognition reported 44% and 57% greater pandemic-era and future-intended telemedicine use, respectively, while Black beneficiaries with MCID reported 57% greater pandemic-era telemedicine use. Our findings suggest that pandemic-era telemedicine utilization was especially common among racial and ethnic minority groups and those with MCID.
Characterization of a novel GRHL2 mutation reveals molecular mechanisms underlying autosomal dominant hearing loss (DFNA28): insights from structural and functional studies
Authors: Oziębło Dominika , Bałdyga Natalia , Leja Marcin L , Jarmuła Adam , Wilanowski Tomasz , Skarżyński Henryk , Ołdak Monika 
Published: January 2025

Abstract
The GRHL2 gene, encoding the Grainyhead-like 2 transcription factor, is essential for various biological processes. While GRHL2 has a complex role in cancer biology, its genetic variants have been also implicated in different forms of hearing loss (HL), including autosomal dominant non-syndromic hearing loss (DFNA28). Here, we report a novel c.1061C&gt;T, p.(Ala354Val) mutation within the DNA binding domain (DBD) of GRHL2 that was identified in a three-generation HL family using a targeted multi-gene panel covering 237 HL-related genes. Unlike the previously reported DFNA28-causing variants that result in protein truncation, the impact of the p.(Ala354Val) missense change cannot be attributed to GRHL2 transcript level or composition, but to an alteration in protein function. Molecular dynamics simulations revealed destabilization of the p.(Ala354Val) mutant GRHL2 dimer interface and an altered DNA binding dynamics, leading to chaotic interaction patterns despite increased binding affinity to DNA. Functional assays demonstrated that the p.(Ala354Val) mutation and other DFNA28-related mutations in the DBD lead to loss of GRHL2 transcriptional transactivation activity, while the p.(Arg537Profs*11) mutation in the dimerization domain results in a gain-of-function effect. The findings indicate that both GRHL2 haploinsufficiency and gain-of-function contribute to HL and underscore the complex regulatory role of GRHL2 in maintaining proper function of the auditory system. Our study emphasizes the need to consider structural and functional aspects of gene variants to better understand their pathogenic potential. As GRHL2 is involved in a multitude of cellular processes, the data gathered here can be also applicable to other conditions.
Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA®), for the Prevention of Recurrent Clostridioides difficile Infection in Participants With Inflammatory Bowel Disease in PUNCH CD3-OLS
Authors: Allegretti Jessica R , Feuerstadt Paul , Knapple Whitfield L , Orenstein Robert , Pinton Philippe , Sheh Alexander , Khanna Sahil 
Published: January 2025

Abstract

Background
Fecal microbiota, live-jslm (RBL; REBYOTA®), is the first single-dose, broad consortia, microbiota-based live biotherapeutic approved by the US Food and Drug Administration to prevent recurrent Clostridioides difficile infection (rCDI) in adults following standard-of-care antimicrobials. Inflammatory bowel disease (IBD) is a common risk factor for rCDI, yet patients with IBD are often excluded from prospective trials. This subgroup analysis of PUNCH CD3-OLS (NCT03931941) evaluated the safety and efficacy of RBL in participants with rCDI and IBD.

Methods
Participants with IBD (ulcerative colitis [UC], Crohn’s disease [CD], or unspecified) who had rCDI were included. Treatment-emergent adverse event (TEAE) data were collected for up to 6 months following RBL administration. Efficacy outcomes included treatment success at 8 weeks and sustained clinical response at 6 months.

Results
Overall, 793 participants were enrolled, and 697 received RBL; 74 had IBD (UC: n = 45; CD: n = 25; unspecified IBD: n = 4). TEAEs within 8 weeks of administration were reported by 45.9% and 47.5% of participants with and without IBD, respectively; most were mild or moderate gastrointestinal symptoms. Serious TEAEs within 8 weeks of administration were reported by 1.4% and 4.2% of participants with and without IBD, respectively. The treatment success rate at 8 weeks was 78.9%, and the sustained clinical response rate at 6 months was 91.1% in participants with IBD, similar to rates in participants without IBD (73.2% and 91.0%, respectively).

Conclusions
The results of this subgroup analysis of PUNCH CD3-OLS suggest RBL is safe and efficacious in patients with IBD.
Enhancing Probiotic, Sensory, and Antioxidant Properties of Polygonatum sibiricum Red. and Crataegus pinnatifida Bunge through Lactic Acid Fermentation for Functional Food Development
Authors: Ma Yan-Li , Wang Yin-Zhuang , Feng Yuan , Duan Ding-ding , Yang Hai-yan , Wang Jun 
Published: January 2025

Abstract
This study explores the use of Polygonatum sibiricum Red. and Crataegus pinnatifida Bunge as edible-medicine homology ingredients through lactic acid fermentation to enhance probiotic content, sensory quality, and antioxidant properties. Using a mixed culture of Lactobacillus plantarum AS1.2437 and Lactobacillus casei CICC21019, the fermentation significantly increased lactic acid bacteria counts, improved taste, and boosted antioxidant activities, particularly in reducing Fe3+ and scavenging DPPH and ABTS free radicals (P &lt; 0.05). During fermentation, changes in reducing sugars, total acids, superoxide dismutase (SOD) activity, and amino acid compositions were monitored. Results showed significant increases in total phenols, flavonoids, SOD activity, and polysaccharide content (P &lt; 0.05). Essential amino acids increased by 4.86%, and therapeutic amino acids rose from 50.88% to 53.59%. The Boltzmann model effectively captured these changes, achieving a high coefficient of determination (R2 &gt; 0.99), indicating strong predictive accuracy. Key organic acids like lactic, acetic, and tartaric acids contributed to enhanced antioxidant activity. This research provides a comprehensive understanding of the physicochemical, medicinal, and antioxidant properties of the fermented Polygonatum sibiricum Red. and C. pinnatifida Bunge (PsR.-CpB.) enzyme, establishing a theoretical foundation for developing functional foods aligned with the edible-medicine homology concept.
Quantitative Evaluation of Multiple Treatment Regimens for Treatment-Resistant Depression
Authors: Feng Yulin , Lv Yinghua , Yang Juan , Xu Ling , Chen Junchao , Huang Jihan , Ren Jiyuan , Zheng Qingshan , Li Lujin 
Published: January 2025

Abstract

Objective
This study aims to quantitatively evaluate the efficacy and safety of various treatment regimens for treatment-resistant depression (TRD) across oral, intravenous, and intranasal routes to inform clinical guidelines.

Methods
A systematic review identified randomized controlled trials on TRD, with efficacy measured by changes in the Montgomery-Åsberg Depression Rating Scale (MADRS). We developed pharmacodynamic and covariate models for different administration routes, using Monte Carlo simulations to estimate efficacy distribution. Dropout and adverse event-related dropout rates were analyzed via single-arm meta-analysis.

Results
Involving 22 studies with 56 treatment arms and 3,059 patients, our findings suggest combination therapies outperform monotherapy, achieving an additional 6.5% reduction in MADRS scores over 12 weeks. The most effective combinations were olanzapine with fluoxetine and quetiapine with SSRIs/SNRIs. Injectable treatments, particularly ayahuasca, produced rapid effects, with a 77% reduction in MADRS scores at 15 days. Intranasal treatments reached efficacy sooner than oral ones, with 28-day efficacy similar to the 12-week efficacy of the olanzapine-fluoxetine combination. Dropout rates due to adverse events were similar across methods (4.5%-5.2%), but total dropouts were highest for oral (17.9%) and lowest for intranasal routes (10.6%). Additionally, there was considerable variation in the incidence of headache, dizziness, and nausea across different administration routes.

Conclusion
The quantitative evaluation of 22 TRD treatments illuminates key pharmacodynamic parameters, bolstering the development of clinical guidelines and aiding the design of clinical trials and medical decision-making.
Uniqueness of Blowups for Forced Mean Curvature Flow
Authors: Hirsch Sven , Zhu Jonathan J 
Published: January 2025

Abstract
We prove uniqueness of tangent cones for forced mean curvature flow, at both closed self-shrinkers and round cylindrical self-shrinkers, in any codimension. The corresponding results for mean curvature flow in Euclidean space were proven by Schulze and Colding–Minicozzi, respectively. We adapt their methods to handle the presence of the forcing term, which vanishes in the blow-up limit but complicates the analysis along the rescaled flow. Our results naturally include the case of mean curvature flows in Riemannian manifolds.
Microplastics in rivers of Gujarat (India) until the Arabian Sea: assessment of the sources, distribution and associated environmental risk
Authors: Prasad Girija , Mohanty Smita , Chakraborty Paromita , Bharat Girija K 
Published: January 2025

Abstract
Microplastics (MPs) have become a notable concern and are released into the environment through the disposal or fragmentation of large plastics. Rivers have been the major pathways for MPs present in the oceans, which significantly affects the marine environment. In the current study, water samples were collected from the upper stream and downstream of Damanganga and Tapi rivers across different sites in the state of Gujarat, India for exploration of MPs contamination. Additionally, samples were also collected from Dumas Beach to detect the presence of MPs. MPs were extracted from the samples through sieving, density separation and wet peroxide oxidation (WPO) techniques which were subsequently analyzed using μ-FTIR, optical microscope, Pyrolysis GCMS (Py-GCMS) and SEM. The concentration of MPs was also quantified from each stretch of Damanganga, Tapi rivers as well as Dumas Beach. Findings revealed that Damanganga showed a higher concentration (3.53 particles/L) of MPs as compared to others. Further, optical microscope and μ-FTIR analysis confirm the presence of MPs like Polypropylene (PP), Polystyrene (PS), Polyethylene terephthalate (PET), Polyethylene (PE) and Polymethyl Methacrylate (PMMA). Pyrolysis products of PP, PS and Polyamide (PA) were detected from Py-GCMS studies. Additionally, SEM images revealed that MPs were subjected to weathering, oxidation and atmospheric deposition over the years. The study additionally confirmed the flux of MPs in both the rivers and beach due to anthropogenic and industrial effects. Risk assessment of MPs was performed using the Pollutant Loading Index (PLI), which indicated that the overall MPs pollution in the studied sites was marginal. Nevertheless, the PLI scores revealed that Damanganga was the most prone to MP pollution among the three study sites.
High-Sensitivity Cardiac Troponin Assays: From Implementation to Resource Utilization and Cost Effectiveness
Authors: Lee Hong-Kee , McCarthy Cian P , Jaffe Allan S , Body Richard , Alotaibi Ahmed , Sandoval Yader , Januzzi James L 
Published: January 2025

Abstract

Background
Cardiac troponin is the gold-standard biomarker for the evaluation of patients with suspected acute myocardial infarction (MI). Improvements in assay technology have led to high-sensitivity cardiac troponin assays that, when incorporated into accelerated diagnostic pathways, may rapidly diagnose or exclude acute MI more efficiently than conventional troponin assays.

Content
In this narrative review, we provide practical suggestions for implementing high-sensitivity cardiac troponin assays, review accelerated diagnostic pathways incorporating these assays, and review the impact of these assays on resource utilization and cost-effectiveness in relation to the evaluation of individuals with possible acute MI.

Summary
An increasing number of hospitals are transitioning to high-sensitivity cardiac troponin assays. This narrative review provides an overview of the potential benefits of this transition.
Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice
Authors: Matsuoka Masatake , Uchibe Kenta , Tang Ningfeng , Tian Hongying , Suzuki Akiko , Oichi Takeshi , Usami Yu , Alferiev Ivan , Otsuru Satoru , Abzug Joshua M , Herzenberg John E , Pacifici Maurizio , Enomoto-Iwamoto Motomi , Chorny Michael , Iwamoto Masahiro 
Published: January 2025

Abstract
Growth-plate (GP) injures in limbs and other sites can impair GP function and cause deceleration of bone growth, leading to progressive bone lengthening imbalance, deformities and/or physical discomfort, decreased motion and pain. At present, surgical interventions are the only means available to correct these conditions by suppressing the GP activity in the unaffected limb and/or other bones in the ipsilateral region. Here, we aimed to develop a pharmacologic treatment of GP growth imbalance that involves local application of nanoparticles-based controlled release of a selective retinoic acid nuclear receptor gamma (RARγ) agonist drug. When RARγ agonist-loaded nanoparticles were implanted near the medial and lateral sides of proximal tibial growth plate in juvenile C57BL/6j mice, the GP underwent involution and closure. Overall tibia length was shortened compared to the contralateral element implanted with drug-free control nanoparticles. Importantly, when the RARγ agonist nanoparticles were implanted on the lateral side only, the adjacent epiphysis tilted toward the lateral site, leading to apical angulation of the tibia. In contrast to the local selectivity of these responses, systemic administration of RARγ agonists led to GP closure at many sites, inhibiting skeletal growth over time. Agonists for RARα and RARβ elicited no obvious responses over parallel regimens. Our findings provide novel evidence that RARγ agonist-loaded nanoparticles can control activity, function and directionality of a targeted GP, offering a potential and clinically-relevant alternative or supplementation to surgical correction of limb length discrepancy and angular deformities.
A case of Li–Fraumeni syndrome caused by a 3.6 kb deletion in the TP53 gene suggested by additional data from the NCC Oncopanel
Authors: Souma Satoshi , Ogawa Maki , Ito Shin , Yamaguchi Kazunori , Fujimori Haruna , Asano Naoki , Ohnuki Koji , Takeuchi Mika , Otsuka Kazunori , Shirota Hidekazu , Yasuda Jun 
Published: January 2025

Abstract
A Japanese woman with Li–Fraumeni syndrome in her 40s underwent comprehensive genetic profiling accompanied by germline data using the Oncoguide NCC Oncopanel, but no germline pathogenic variants in the tumor suppressor gene TP53 were detected. However, careful examination of additional data in the report suggested the presence of a large TP53 deletion. Custom targeting next-generation sequencing and nanopore sequencing revealed a 3.6 kb deletion located between intron 1 and intron 6 of TP53. This finding indicates that the NCC Oncopanel is suggestive for detecting large germline deletions in tumor suppressor genes.
Significance of adding chemotherapy to radiotherapy in the treatment of T2N0 glottic cancer
Authors: Sano Daisuke , Oridate Nobuhiko 
Published: January 2025

Abstract
The prognosis for T2N0 glottic squamous cell carcinoma (SCC) is generally favorable, with a 5-year overall survival rate of 79%–96% achieved with radiotherapy (RT), the standard nonsurgical treatment for this condition. However, the local control rate for T2N0 glottic SCC treated with RT remains suboptimal, with a 5-year local control rate of only 65%–80%. Local residual disease or recurrence following RT for T2N0 glottic SCC often leads to difficulties in laryngeal preservation. When total laryngectomy is performed as a salvage surgery in such cases, patients lose their physiological ability to speak. Therefore, improving local control and laryngeal preservation rates through RT could substantially improve the quality of life of these patients. Attempts have been made to combine cytotoxic anticancer agents with RT to achieve better local control in patients with T2N0 glottic SCC. In Japan, several studies have evaluated the effects of combining S-1, an oral fluorinated pyrimidine, with RT in these patients. This review highlights the importance of adding chemotherapy to RT in the treatment of patients with T2N0 glottic SCC.
Myiasis by Cordylobia anthropophaga and C. rodhaini (Diptera: Calliphoridae) in Polish travelers to Africa with new molecular data
Authors: Biernat Beata , Gładysz Paweł , Kuna Anna , Sulima Małgorzata , Bykowska-Tumasz Martyna , Sontag Elżbieta 
Published: January 2025

Abstract
Myiasis is a parasitic infestation of soft vertebrate tissues by larval stages of Diptera. We briefly described the lesion-causing genus Cordylobia Grünberg (Diptera: Calliphoridae). Three Polish travelers to Uganda, Gambia, and Senegal returned with furuncular myiasis. To identify the third-instar larvae removed from their skin, we examined the morphological features of the 3 specimens and sequenced a 5’ barcoding fragment of the cytochrome c oxidase subunit I gene (COI-5P). One larva was identified as C. rodhaini Gedoelst, and 2 larvae were identified as C. anthropophaga (Blanchard). We were the first to submit the COI-5P of C. rodhaini to GenBank and the Barcode of Life Database. This is the first record of the importation of C. anthropophaga and the second record of the importation of C. rodhaini to Poland.