bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mario Botta Architetti – Stabilimento termale Fortyseven° a Baden, Svizzera
Authors: Guerra Brunella 
Published: February 2024

Nel 2008 Mario Botta viene incaricato di progettare un nuovo stabilimento termale a Baden, cittadina svizzera a nord ovest di Zurigo nello stesso sito dove sorgevano delle antiche terme romane, proprio lungo il fiume Limmat. Senza ricorrere alla mimetizzazione, Botta dà vita a una natura artificiata che è sintesi tra elemento naturale ed elemento storico-culturale.
Mario Botta was commissioned in 2008 to design a new spa in Baden, a Swiss town to the north-west of Zurich, on the same site where an ancient Roman bath once stood, on the banks the Limmat river. Without attempting to blend in with the background, Botta creates an artificial nature that is a fusion of natural and cultural-historical elements.
Miller & Maranta Architekten – Rinnovo e ampliamento del Vecchio Ospizio San Gottardo, Svizzera
Authors: Privitera Francesca 
Published: February 2024

La lettura, tra Storia e analogia, del Passo del San Gottardo è il dato di partenza imprescindibile del progetto di Miller & Maranta per il rinnovamento del Vecchio Ospizio San Gottardo. I progettisti affidano al disegno della copertura, un tetto a falda dalla geometria atipica, la ridefinizione morfologica, l’espressività e il contenuto simbolico dell’Ospizio, generando una ramificazione di significati che conducono l’architettura verso interpretazioni non scontate.
The reading, both in terms of history and analogy, of the Gotthard Pass, is the inevitable starting point of Miller & Maranta’s design for the renovation of the Old St. Gotthard Hospice. The architects entrust the morphological redefinition, expressiveness and symbolic content of the Hospice to the design of the roof, pitched and with an atypical geometrical shape, thus generating a ramification of meanings that lead the architecture toward unexpected interpretations.
Caruso St John Architects – Spazio per l’organo nella Cattedrale di Canterbury, Regno Unito
Authors: Cosentino Giuseppe 
Published: February 2024

Nel 2016 lo studio Caruso St John progetta per l’organo della Cattedrale di Canterbury un luogo della musica ma ancor prima del silenzio, che nella sintassi musicale assume la forma della pausa. Una sospensione che, se nella musica è predisposizione all’attesa, anticipazione del suono e promessa di un inizio, nel progetto della Cattedrale diventa interruzione fisica, una cesura che si realizza come distacco da terra. Il lavoro sullo spazio di Caruso St John nasce da una meditata ricerca sul contesto con un esercizio costante che non si esaurisce solo nell’analisi storica e architettonica ma che, per evocazione di immagini affini, include nella lettura del luogo tutti i campi dell’arte.
In 2016, the Caruso St John studio designed for the organ of Canterbury Cathedral a place of music but even more so of silence, which in musical syntax is expressed by the pause. A suspension which in music is a readiness to wait, the anticipation of sound and the promise of a beginning, and that in the project for the Cathedral becomes a physical interruption, a break that is accomplished as a detachment from the ground. The work on the space carried out by Caruso St John derives from thoughtful research on the context through a constant exercise that is not limited to historical and architectural analysis but, by evocation of related images, includes all fields of art in the interpretation of the place.
OTO Arquitectos – Centro del Parco Naturale di Fogo, Capo Verde
Authors: Fabbrizzi Fabio 
Published: February 2024

Nella superfice interna della caldera dell’Isola di Fogo a Capo Verde, gli OTO Arquitectos hanno realizzato nel 2013 l’edificio ospitante la sede generale del Parque Natural do Fogo. una forma nata dal luogo per il luogo, una nuova topografia, capace di alterare la relazione tra la figura e lo sfondo, grazie alla quale si vive quotidianamente la sublime esperienza dell’attesa e della distruzione. Ad un anno dalla sua inaugurazione, l’attesa diviene realtà e l’edificio viene completamente distrutto dalla più grande eruzione che mai si ricordi a memoria d’uomo nell’Isola.
In 2013, OTO Arquitectos constructed the building for the general headquarters of the Parque Natural do Fogo in the inner surface of the caldera of Fogo Island in Cape Verde. A form derived from the place and for the place, a new topography capable of altering the relationship between the figure and the background, thanks to which the sublime experience of both waiting and of destruction can be experienced on a daily basis. One year after its inauguration, the waiting became reality when the building was completely destroyed by the largest eruption of which there is memory on the Island.
Il cimitero di Parabita di Anselmi e Chiatante nella lettura fotografica di Paolo Barbaro
Authors: Arrigoni Fabrizio 
Published: February 2024

Il progetto di Alessandro Anselmi e Paola Chiatante per il Nuovo Cimitero Comunale a Parabita (Lecce) porta a compimento le ricerche promosse all’interno dell’atelier G.R.A.U. dall’inizio degli anni sessanta e contribuisce a inaugurare una stagione di compiuta emancipazione da quella “superstizione del nuovo” oramai avvertita come un’ossificata ortodossia accademico-professionale. Un’attenzione ai contenuti e ai processi specifici della disciplina e un confronto aperto con gli archetipi e i codici linguistici e simbolici che spessorano l’esperienza storica costituiscono le premesse da cui origina un’opera tanto concettualmente complessa e articolata quanto fortemente espressiva nella sua sostanza costruita.
Alessandro Anselmi and Paola Chiatante’s project for the New Municipal Cemetery in Parabita (Lecce) is the result of the research carried out within the G.R.A.U. atelier since the early Sixties and contributes to heralding a period of accomplished emancipation from that “superstition of the new” which by then was perceived as ossified academic-professional orthodoxy. A focus on field-specific content and processes, as well as an open dialogue with the archetypes, as well as with the linguistic and symbolic codes that enhance historical experience constitute the premises from which originates a work that is as conceptually complex and articulate as it is strongly expressive in its built substance.
Sigurd Lewerentz. Centro parrocchiale Sankt Petri, Klippan, Svezia
Authors: De Felice Chiara 
Published: February 2024

Il centro Parrocchiale di San Pietro a Klippan appartiene all’ultimissima produzione dell’architetto svedese Sigurd Lewerentz. L’architettura da una parte sembra inverare il desiderio di realizzare uno spazio capace di far riaffiorare alcune vibrazioni profonde dell’animo umano troppo spesso sommerse dai suoni acuti dettati dalla società moderna, dall’altra di incarnare l’esercizio più estremo della pratica del progetto, dell’esasperazione della materia, del controllo dei dettagli. Questi due registri affiancati producono uno spazio inaspettato e starniante.
St Peter's Parish Centre in Klippan belongs to the very last period of production of the Swedish architect Sigurd Lewerentz. The architecture seems to reflect, on the one hand, the wish to create a space that is capable of bringing to the surface certain deep vibrations of the human soul that are too often drowned by the high-pitched sounds produced by modern society, and to embody, on the other, the most rigorous design practice, the heightening of materials and the mastering of details. These two registers working alongside each other produce an unexpected and estranging space.
Andare in mille pezzi per ritrovare una forma
Authors: Brancaleoni Gabriele 
Published: February 2024

Il seguente contributo propone una riflessione inerente all'educazione alla letterarietà e all’accompagnamento dell’infanzia alla frequentazione di storie.
La complessità dell'esperienza della lettura viene analizzata e approfondita attraverso un parallelismo con una metafora letteraria radicata nel nostro immaginario già a partire dal racconto del mito di Osiride raccontatoci da Plutarco, fino ad arrivare a classici contemporanei, passando attraverso versioni di fiabe, albi illustrati, canzoni e serie televisive: la metafora dello smembramento.
Vague Language in L2 Corpora of Russian
Authors: Maiko Tatsiana 
Published: February 2024

Vague language has been explored in a variety of languages, including Russian. There is also a growing body of research into vague language used by L2 speakers, predominantly of English. Vague language of Russian L2 learners has not yet been addressed.
The present study focuses on the use of vague language by Italian-speaking learners of Russian based on the data of 2 learner corpora. It deals with main categories of vague language: vague nouns (вещь ‘thing’), approximators (около десяти ‘around ten’), and general extenders (и так далее ‘and so on’). The aim of the study is to identify how extensively and in what contexts Italian learners of Russian resort to vague language and to compare the findings to the use of vague language by native speakers and learners with a different linguistic background (English L1).
“Here, I have measured with my span the Heaven and the Earth”. Some Comments on the Pilgrimage of the Hegumen Daniil (12th Century)
Authors: Preobrazhenskaya Anastasia Aleksandrovna 
Published: February 2024

The 12th-century pilgrimage of hegumen Daniil to the Holy Land is the earliest recorded journey to Jerusalem by a Russian. The pilgrimage has been studied widely, especially because of the multiple measurements Daniil used to describe the places he visited. No other Russian pilgrim who went to Constantinople or Jerusalem after Daniil was so interested in measuring things. The question arises why these measurements were so necessary for Daniil and whether they have any symbolic meaning. The article attempts to interpret these measurements through a theological and symbolic perspective and argues that these measurements can be seen as a key for understanding the whole text.
When describing the Church of the Holy Sepulcher, Daniil mentions a small ciborium constructed above the omphalos – the navel of the Earth – and a graphite reading Se pędju moeju izměrich nebo i zemlju ‘Here, I have measured with my span the heaven and the earth’. The phrase, though closely resembling Is 40:12, is rather a combination of several paraphrased Bible verses, including Ps 38:6. In the article, a linguistic commentary to the phrase is provided, and parallels in the medieval Russian sources are identified and discussed.
Other pilgrims, both Russian and European, do not speak about the graphite, but provide a number of legends connected with the navel, including those in which Jesus (or sometimes Nimrod, a figure from the Old Testament) measures the earth with his own hand and marks the center of the universe in the place where the navel is located. The article argues that Daniil may have known that very legend from his Jerusalem guide, vož dobr ‘a good guide’, and that he incorporated it into his text in the form of a mosaic graphite in order to legitimize it since the written word in Rus’ was deemed sacred and thus always true.
The Effect Of Choking Management Education For Toddlers Aged 1-5 Years On Parents Knowledge
Authors: Ratiyun Rafidaini Sazarni , Colin Vellyza , Rahmawati Ida , Nor Safitri Lala , Anita Noza 
Published: February 2024

Choking is an emergency condition that must be treated quickly, if it takes too long it will result in a lack of oxygen and lead to death due to blockage of the respiratory tract by foreign objects in the form of food, toys, etc. Choking can lead to death due to lack of knowledge of handling choking. The purpose of this study was to determine the effect of education on handling choking in children under five on the knowledge of parents in the working area of ​​the Ratu Agung Health Center, Bengkulu City. This study aims to determine the effect of choking management education on toddlers aged 1-5 years in the working area of ​​Ratu Agung Public Health Center, Bengkulu City. The research design used pre experimental design with a one group pretest posttest design. To determine the number of samples using the Paul Leedy formula with the results obtained are 30 parents who have toddlers aged 1-5 years in the working area of ​​the Ratu Agung Health Center in Bengkulu city. The results of the study: the results of the t-test of two related samples (Paired sample t-test) obtained a value of t = 18.745 with p-value = 0.000 <0.05 significant, so it can be concluded that Ho is rejected and Ha is accepted, which means that there is an effect of handling education. choking in toddlers aged 1-5 on the knowledge of parents in the working area of ​​the Ratu Agung Health Center, Bengkulu city. After educating parents in the working area of ​​the Ratu Agung Health Center, Bengkulu city, out of 30 parents, there were 4 parents (13.3%) who had sufficient knowledge, and 26 parents (86.7%) who had good knowledge with a good score. an average of 35.63 (good).
Psychoeducational Therapy To Increase Self Efficacy In Patients With Pulmonary Tuberculosis
Authors: Hapipah  , Mahendra Efendi Tedy , Istianah  , Hardi Irwan 
Published: February 2024

Pulmonary Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Pulmonary TB can be cured with treatment carried out for 6-8 months. To achieve recovery, the patient must have good self-efficacy so that he will be motivated to recover and strengthen himself to complete the treatment. During TB treatment various problems, both physiological and psychological, can arise, one of which is related to self-efficacy. Increasing self-efficacy during the treatment period is important so that management of psychoeducational therapy is needed. This study to determine the effect of psychoeducational therapy on self-efficacy in pulmonary TB patients in the work area of ​​the Gerung Health Center. This study uses a quantitative research type with the One Group Pre-Post Test Design approach. The sample in this study were 16 people. The research instrument was the GFCSES (Guide For Constructing Self Efficacy Scale) to measure self-efficacy in pulmonary TB patients. Data analysis with Paired T Test. The results showed a p-value of 0.000 (<α 0.05), so it can be concluded that there is a significant effect between psychoeducational therapy on self-efficacy in pulmonary TB patients in the working area of ​​the Gerung Public Health Center. Based on the results of this study, it is necessary to include material related to psychological changes such as self-efficacy in pulmonary TB patients during the treatment process provided by health workers through education carried out in activities at the family integrated service post or health services. Psychoeducational therapy can increase self-efficacy in pulmonary tuberculosis patients

Keyword: Psychoeducational therapy, self efficacy, pulmonary TB
Analysis of Factors Influencing Stigma Against Mental Disorders in Indonesia: Systematic Literature Review
Authors: Davies Jocelyn 
Published: February 2024

Introduction: Stigma towards mental disorders is an important public health problem in Indonesia. This stigma can have a negative impact on the lives of people with mental disorders (ODGM), such as discrimination, social isolation, and an increased risk of suicide. This research aims to analyze the factors that influence the stigma of mental disorders in Indonesia.
Methods: This research uses a systematic literature review method. Research data was obtained from electronic literature searches on PubMed, Medline, and Google Scholar. Research inclusion criteria were research published in reputable scientific journals, published in the 2010-2022 period, and discussing factors that influence the stigma of mental disorders in Indonesia.
Results: The research results show that there are five factors that influence the stigma of mental disorders in Indonesia, namely: low knowledge about mental disorders, negative views about mental disorders, negative experiences with people with mental disorders, cultural factors, and socioeconomic factors.
Conclusion: Negative views about mental disorders can come from various sources, including family, friends, society, and mass media. Education about mental disorders needs to be improved to increase public knowledge about mental disorders.
Onsite serious adverse events reporting: Seven-year experience of the institutional ethics committee of a tertiary care hospital
Authors: Shetty Yashashri Chandrakant , Auti Prajakta D. , Aithal Yashoda Ramachandra 
Published: February 2024

Abstract

Background:
Over the years, Indian regulations have undergone numerous amendments, including stringent reporting deadlines, relatedness requirements, and compensation obligations for serious adverse event (SAE). A historic change, new drugs and trial rules-2019, was proposed on March 19, 2019. The purpose of the study was to ascertain whether various stakeholders were reporting in accordance with the evolving SAE criteria.

Materials and Methods:
Data were retrieved after the Ethics Committee’s approval between August 2014 and December 2021. Data gathered before March 19, 2019, were categorized as “BEFORE” data, while the remaining data were categorized as “AFTER.” Utilizing causality, on-site SAE reporting, and the ethics committee review procedure, we evaluated the compliance. The data were evaluated using descriptive statistics, and the Chi-square or Mann–Whitney tests were used to compare the “BEFORE” and “AFTER” groups.

Results:
A total of 77 SAEs were reported in 26 clinical trials, where most clinical trials were phase III. Endocrine projects made up 9/26 (34.61%). In the cardiology studies, the greatest SAE distribution was 21 SAEs/89 participants (23.59%) with approximately 48% of these being vascular. The “AFTER” group noticed a decrease in the total number and length of SAE subcommittee meetings. In the “AFTER” group, there was a significantly higher median number of agenda items/meetings (8 [4.5–10.75]) (P < 0.0001). The median interval between the onset of SAE and the first reporting date, however, was just 1 day (interquartile range: 1–5 days). In nondeath SAEs, there was no significant difference in the compensation paid. In the “AFTER” group, there were no discrepancies in reporting SAE.

Conclusion:
There is acceptable adherence to SAE reporting criteria.
Predicting skin permeation-enhancing effect of fixed oils using saturated to unsaturated fatty acid ratio content
Authors: Adeoye-Aremu T. , Jaiyeoba K.T. 
Published: February 2024

Background: Transdermal drug delivery is non-invasive and advantageous as it improves patient compliance.
Objective: This study evaluated the effect of varying ratios of saturated to unsaturated fatty acids in fixed oils on the permeation of ibuprofen across pig dorsal skin.
Methods: The solubility of ibuprofen in soybean oil, theobroma oil, and shea butter (fixed oils) was evaluated and in vitro skin permeation studies were conducted using Franz diffusion cells.
Results: A significant difference in permeability parameters, such as flux and effective skin permeability, in the different formulations was observed. Skin permeation depended on the ratio of saturated to unsaturated fatty acids. It also depended on the type and concentration of individual saturated and unsaturated fatty acids present in the fixed oils. The skin permeation of ibuprofen increased with an increasing ratio of palmitic acid (PA) to oleic acid (OA) concentrations. The highest flux was obtained in the theobroma oil formulation, with a PA:OA ratio of 0.78. The lowest flux was obtained in the shea butter formulation, with a PA:OA ratio of 0.09. The PA:OA ratio was 0.46 in the soybean oil formulation.
Conclusion: These results suggest that the ratio of saturated to unsaturated fatty acids in fixed oils could be used as a model for predicting the rate of skin permeation of drugs in oil-based formulations. Depending on the desired rate of drug permeation, different combinations of the ratio of saturated to unsaturated fatty acids can be used in formulations for transdermal delivery.
Toxic effects of clindamycin-hydrochloride in healthy rodents
Authors: Onyegbula K.C. , Edonkumoh M. 
Published: February 2024

Background: Systemic administration of clindamycin-hydrochloride (an antibiotic) is mainly associated with gastro-intestinal disturbances and allergic reactions. Little is known of its haematological and biochemical toxicity.
Objective: To evaluate the haematological and biochemical changes associated with indiscriminate administration of oral clindamycin-hydrochloride in clinically healthy rodents.
Materials and Methods: Twenty Wistar rats (130-189 grams) divided into four groups (A-D) of five rats each were used. Rats in group A (control) were treated with distilled water. Groups B-D received 0.2mL (below normal dose), 0.4mL (normal dose) and 1.0mL (above normal dose) of clindamycin-hydrochloride (75mg/5mL) at 8 hourly intervals, three times daily for 14 days, respectively. Thereafter, blood was collected through both ocular and cardiac puncture into ethylene diamine tetra acetic acid (EDTA) and lithium heparin bottles for evaluation of haematological and biochemical parameters, respectively.
Results: Significant (P < 0.05) increases in total white blood cell (WBC) counts and decreases in eosinophil (Eos) counts occurred in clindamycin-treated rats. In addition, significant (P < 0.05) increases in concentrations of Total cholesterol, Triglyceride and High-density lipoprotein, respectively, as well as decreases in concentrations of Albumin, Alanine transaminase and Gamma-glutamyl transpeptidase, respectively also occurred in clindamycin-treated rats.
Conclusion: Indiscriminate use of clindamycin-hydrochloride produces adverse haematological and biochemical changes in Wistar rats which may be a reflection of systemic toxicity, allergic reaction as well as liver and kidney dysfunction.
Hearing loss can also be seen in patients with nonradiographic axial spondyloarthropathies as well as radiographic axial spondyloarthropathies
Authors: Çağlar Yağcı Hanife , Yağcı İlker , İlkay Özdamar Osman , Tosyalı Salman Cansu , Ertuğrul Özlem 
Published: February 2024

Objectives: Hearing loss has been described in patients with radiographic axial spondyloarthropathies (R-AxSpA) but has not been studied in patients with non-radiographic axial spondyloarthropathies (NR-AxSpA); accordingly, the aim of the study was to compare hearing loss in patients with NR-AxSpA, R-AxSpA, and healthy individuals.
Patients and methods: This cross-sectional observational study was conducted with 68 participants (30 males, 38 females; mean age: 39.8±7.4 years) between March 2021 and March 2022. Of the participants, 16 were patients with NR-AxSpA, 15 were patients with R-AxSpA, and 37 were healthy controls. Disease activity and radiological and audiological features were analyzed. The audiological assessment included pure-tone audiometric tests at octave frequencies of 250 to 8000 Hz and transient evoked otoacoustic emissions.
Results: Hearing loss was found in three (8%) in the healthy group, five (31.3%) in the NR-AxSpA group, and 10 (66.7%) in the R-AxSpA group. The chi-square analysis showed a statistical significance (p=0.001). Values of audiometric tests yielded significant differences between the control and R-AxSpA group and also the control and NR-AxSpA group. For the air conduction studies, the statistical significance began at 1000 Hz in the R-AxSpA group. It was found that in the NR-AxSpA group, the statistical difference started in higher frequencies. The bone conduction audiometric studies were similar to air conduction studies. Transient evoked otoacoustic emission studies showed that the R-AxSpA group was significantly affected compared to the control and NR-AxSpA groups. There was no statistical difference between the control and NR-AxSpA groups.
Conclusion: Both NR-AxSpA and R-AxSpA patients had hearing loss; however, in pure-tone audiometric tests, the abnormalities began in lower frequencies in the R-AxSpA group than in the NR-AxSpA group.