bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of supraclavicular brachiocephalic and femoral vein approaches for tunneled dialysis catheter placement in patients with thrombosed internal jugular veins
Authors: Oguslu Umut , Gümüş Burçak , Yalçin Murat , Sahin Osman Zikrullah , Yilmaz Gökalp 
Published: October 2023

AbstractIntroductionThere is still debate on the best access route in case of bilateral internal jugular vein thrombosis. We aimed to compare the safety, effectiveness, and outcomes of tunneled dialysis catheter placement via supraclavicular brachiocephalic and femoral vein approaches in patients with bilateral internal jugular vein thrombosis.MethodsBetween January 2018 and December 2021, data of the patients in whom tunneled dialysis catheters were placed via the supraclavicular brachiocephalic vein (n = 42) and femoral vein (n = 57) approaches were extracted. Patient demographics, technical and clinical success rates, complications, and outcomes were noted. The Likert scale was used to assess patient satisfaction.FindingsForty two (42.4%) patients were men, and the mean age was 61.9 (range, 12–93) years. The technical and clinical success rate was 100% for both groups. No major complication was encountered. The mean follow‐up period was 497.5 (range, 32–1698) catheter days. Thirty‐day patency was similar for the brachiocephalic vein and femoral vein group (40 [95.2%] vs. 55 [96.5%], p = 0.754). Also, primary and cumulative patency rates were comparable (p = 0.158; p = 0.660). The infection rate was 2.6 and 4.1 per 1000 catheter days for the brachiocephalic vein and femoral vein group. The infection‐free survival was significantly higher in the brachiocephalic vein group (71.9% vs. 35.3% at 12 months, p < 0.001). Patient satisfaction was higher in the brachiocephalic vein group (median satisfaction, 5 vs. 4, p < 0.001).DiscussionBoth supraclavicular brachiocephalic vein and femoral vein approaches have high technical and clinical success with comparable patency rates. However, low infection rate and high patient satisfaction make the supraclavicular brachiocephalic vein approach a reasonable alternative before proceeding to the femoral vein access.
UV filter occurrence in beach water of the Mediterranean coast – A field survey over 2 years in Palavas‐les‐Flots, France
Authors: Thallinger Delphine , Labille Jerome , Milinkovitch Thomas , Boudenne Jean‐Luc , Loosli Frédéric , Slomberg Danielle , Angeletti Bernard , Lefrançois Christel 
Published: October 2023

AbstractObjectiveA 2‐year sampling campaign was realized on French Mediterranean beach (Palavas‐les‐Flots Hérault) in order to measure the concentration of UV filters released from the sunscreen used by bathers. Multiple factors suspected of playing determining roles in the UV filter pattern in water were explored, such as the seasonal and daily time evolutions, or the vertical and horizontal distributions, and they were regarded through the UV filter characteristics.MethodsThe beach was monitored during periods of high and low tourist attendance, typically before, during and after the summer peak. The beachgoers attendance was counted. Bathing water was sampled distinctly from the bulk column and from the top surface layer, testing different sampling tools. Sediments and mussels were also sampled and analysed as potential UV filter sinks. Three organic UV filters (octocrylene OCR, avobenzone BMDBM and octyl methoxycinnamate OMC) and one mineral (titanium dioxide TiO2) were studied here as representatives of the current cosmetic market.ResultsSummer peak attendance on the beach was confirmed associated with peak levels of UV filter concentration in the bathing water, even more pronounced during a heat wave period. This relation was also observed at day scale with an afternoon peak, suggesting a rapid evolution of the UV filter pattern in water. Contrasted fates were measured between the four studied UV filters, that could be mainly explained by their respective characteristics, i.e. particulate or dissolved, hydrophilic or lipophilic, lifetime. Generally, this resulted in a concentration ranking TiO2 > OCR > OMC > BMDBM, ranging from 0.5 to 500 μg/L. The most lipophilic and recalcitrant OCR was found most vertically differentiated and over concentrated in the top surface layer of water. Finally, a large horizontal heterogeneity was also observed in the UV filter concentration pattern, raising the need for sample replicates that cover a significant area.ConclusionThis work fulfils some knowledge gaps on the issue of UV filter release in coastal environments, not only by providing original field data and methodological recommendations but also importantly in the comparison made of organic and mineral UV filters, which are often considered separately and rarely evaluated at the same time.
Renal cell carcinoma outcomes in end‐stage renal disease: A 40‐year study from two Japanese institutions
Authors: Ishihara Hiroki , Ikeda Takashi , Fukuda Hironori , Yoshida Kazuhiko , Kobayashi Hirohito , Iizuka Junpei , Nagashima Yoji , Kondo Tsunenori , Takagi Toshio 
Published: October 2023

ObjectivesThe objective of the study was to analyze the outcomes of patients with renal cell carcinoma (RCC) arising in end‐stage renal disease (ESRD) over a 40‐year span.MethodsWe retrospectively evaluated data of patients with ESRD‐RCC diagnosed between 1979 and 2020 at two institutions. We assessed changes in stage, surgical approaches, and cancer‐specific survival (CSS) following nephrectomy according to era between ESRD‐RCC and sporadic RCC. Furthermore, perioperative outcomes in patients with ESRD‐RCC were compared between laparoscopic and open surgery.ResultsPatients with ESRD‐RCC (n = 549) were diagnosed at an earlier stage (p = 0.0276), and the ratio of laparoscopic nephrectomy was increased (p < 0.0001) according to eras. Since 2000 (i.e., after implementation of laparoscopic nephrectomy), patients with ESRD‐RCC (n = 305) had significantly shorter CSS (p = 0.0063) after nephrectomy than sporadic RCC (n = 2732). After adjustment by multivariate analysis and propensity score matching, ESRD status was independently associated with shorter CSS (p = 0.0055 and p = 0.0473, respectively). Improved CSS in sporadic RCC (p < 0.0001), but not ESRD‐RCC (p = 0.904), according to era contributed to this difference. Laparoscopic nephrectomy showed favorable outcomes, including shorter surgery time, lower estimated bleeding volumes, transfusion rates, and readmission rates, and shorter postoperative hospitalization than open nephrectomy (p < 0.05).ConclusionsAdvances in diagnostic and treatment modalities potentially enable early diagnosis and minimally invasive surgery for patients with ESRD‐RCC. As ESRD‐RCC may not present indolently, careful post‐operative monitoring is needed.
Practitioner Review: Clinical utility of the QbTest for the assessment and diagnosis of attention‐deficit/hyperactivity disorder – a systematic review and meta‐analysis
Authors: Bellato Alessio , Hall Charlotte L. , Groom Madeleine J. , Simonoff Emily , Thapar Anita , Hollis Chris , Cortese Samuele 
Published: October 2023

BackgroundSeveral computerised cognitive tests (e.g. continuous performance test) have been developed to support the clinical assessment of attention‐deficit/hyperactivity disorder (ADHD). Here, we appraised the evidence‐base underpinning the use of one of these tests – the QbTest – in clinical practice, by conducting a systematic review and meta‐analysis investigating its accuracy and clinical utility.MethodsBased on a preregistered protocol (CRD42022377671), we searched PubMed, Medline, Ovid Embase, APA PsycINFO and Web of Science on 15th August 2022, with no language/type of document restrictions. We included studies reporting accuracy measures (e.g. sensitivity, specificity, or Area under the Receiver Operating Characteristics Curve, AUC) for QbTest in discriminating between people with and without DSM/ICD ADHD diagnosis. Risk of bias was assessed with the Quality Assessment of Diagnostic Accuracy Studies tool (QUADAS‐2). A generic inverse variance meta‐analysis was conducted on AUC scores. Pooled sensitivity and specificity were calculated using a random‐effects bivariate model in R.ResultsWe included 15 studies (2,058 participants; 48.6% with ADHD). QbTest Total scores showed acceptable, rather than good, sensitivity (0.78 [95% confidence interval: 0.69; 0.85]) and specificity (0.70 [0.57; 0.81]), while subscales showed low‐to‐moderate sensitivity (ranging from 0.48 [0.35; 0.61] to 0.65 [0.52; 0.75]) and moderate‐to‐good specificity (from 0.65 [0.48; 0.78] to 0.83 [0.60; 0.94]). Pooled AUC scores suggested moderate‐to‐acceptable discriminative ability (Q‐Total: 0.72 [0.57; 0.87]; Q‐Activity: 0.67 [0.58; 0.77); Q‐Inattention: 0.66 [0.59; 0.72]; Q‐Impulsivity: 0.59 [0.53; 0.64]).ConclusionsWhen used on their own, QbTest scores available to clinicians are not sufficiently accurate in discriminating between ADHD and non‐ADHD clinical cases. Therefore, the QbTest should not be used as stand‐alone screening or diagnostic tool, or as a triage system for accepting individuals on the waiting‐list for clinical services. However, when used as an adjunct to support a full clinical assessment, QbTest can produce efficiencies in the assessment pathway and reduce the time to diagnosis.
Comparative stable isotope analyses of green sturgeon (Acipenser medirostris) and white sturgeon (A. transmontanus) in the San Francisco estuary
Authors: Miller Emily A. , Singer Gabriel P. , Peterson Matthew L. , Webb Molly , Klimley A. Peter 
Published: October 2023

AbstractGreen sturgeon (Acipenser medirostris) and white sturgeon (A. transmontanus) are closely related, sympatric species that inhabit the San Francisco estuary. Green sturgeon have a more marine life history but both species spawn in the Sacramento River and reside for some duration in San Francisco Bay. These sturgeons are of conservation concern, yet little is known about their dietary competition when they overlap in space and time. To examine evidence of dietary differentiation, we collected whole blood and blood plasma from 26 green sturgeon and 35 white sturgeon in San Francisco Bay. Using carbon and nitrogen stable isotope analyses, we compared their relative trophic levels and foraging locations along the freshwater to marine gradient. Sampling blood plasma and whole blood allowed comparison of dietary integration over shorter and longer time scales, respectively. Plasma and whole blood δ13C values confirmed green sturgeon had more marine dietary sources than white sturgeon. Plasma δ15N values revealed white sturgeon fed at lower trophic levels than green sturgeon recently, however, whole blood δ15N values demonstrated the two species fed at the same trophic level over longer time scales. Larger individuals of both species had higher δ13C values than smaller individuals, reflecting more marine food sources in adulthood. Length did not affect δ15N values of either species. Isotope analyses supported the more marine life history of green than white sturgeon and potentially highlight a temporary trophic differentiation of diet between species during and preceding the overlapping life stage in San Francisco Bay.
Validation of a short food group questionnaire to determine intakes from healthy and unhealthy food groups in 5–9‐year‐old South African children
Authors: Kruger H Salome , Makore Persuade , van Zyl Tertia , Faber Mieke , Ware Lisa J. , Monyeki Makama A. , Kruger Ruan 
Published: October 2023

AbstractBackgroundReliable dietary data for children are necessary to investigate associations with health outcomes. The present study aimed to develop and validate a questionnaire to determine the frequency of intakes of specific healthy and unhealthy food groups in young children.MethodsParticipants were 5–9‐year‐old South African children (n = 920) from 10 urban schools. Their parents completed a demographic questionnaire and the food intake questionnaire with food pictures. Based on the literature, four healthy food groups (fruits, vegetables, milk, meat/fish/poultry/eggs) and six unhealthy food groups (hot and cold sugar‐sweetened beverages, candy, salty snacks, cakes and fast foods) were included, with five different frequency responses. Six experienced nutritionists assessed the face validity and content validity. After pilot testing, construct validity and homogeneity were determined in the participants. Convergent validity was determined using urinary sodium and potassium concentrations as biological intake markers.ResultsNutritionists confirmed face and content validity. Caregivers confirmed understanding of the questionnaire. Three factors explained 50.2% of the variance, with most unhealthy food groups as factor 1, fruits and vegetables as factor 2, and animal source protein and milk groups clustered with sugar‐sweetened beverages as factor 3. The frequency of milk group, fruits and vegetables intake correlated negatively, whereas the frequency of salty snacks and fast foods intakes correlated positively with the urinary sodium:potassium ratio.ConclusionsThe healthy and unhealthy food group questionnaire has advantages of low respondent burden, as well as acceptable content and convergent validity in South African children. The questionnaire may be used to investigate associations between food intakes and health outcomes.
Ecotourism, infrastructures, and the drama of sovereignty on a border island
Authors: Dicenta Mara , Gerrard Ana Cecilia 
Published: October 2023

AbstractThe Ruta 30 scenic road project in Argentine Tierra del Fuego has encountered significant resistance. In this article, we analyze a public hearing convened to assess the road's impacts as an event illuminating the daily dynamics of the region. In this borderland, narratives about sovereignty create a space of liminalities between pasts and futures, centers and peripheries, and living and the dead. In this context, and with Patagonia's expanding conservation and ecotourism frontiers, studying public reflexivity becomes crucial for understanding rapid changes. To this end, we employ Turner's “social drama” concept to analyze the hearing as a performance enacting authorized discourses of experts, policymakers, environmentalists, industry, and workers. We conclude by discussing “liminal governance” in a border territory that transcends neoliberal and sovereign designs, and “impossible opposition,” revealing how the hearing reframed the road conflict as a sovereignty crisis, ultimately mitigating potential disruptions to established settler‐colonial structures.
Fundamental Neurochemistry Review: Copper availability as a potential therapeutic target in progressive supranuclear palsy: Insight from other neurodegenerative diseases
Authors: Billings Jessica L. , Hilton James B. W. , Liddell Jeffrey R. , Hare Dominic J. , Crouch Peter J. 
Published: October 2023

AbstractSince the first description of Parkinson's disease (PD) over two centuries ago, the recognition of rare types of atypical parkinsonism has introduced a spectrum of related PD‐like diseases. Among these is progressive supranuclear palsy (PSP), a neurodegenerative condition that clinically differentiates through the presence of additional symptoms uncommon in PD. As with PD, the initial symptoms of PSP generally present in the sixth decade of life when the underpinning neurodegeneration is already significantly advanced. The causal trigger of neuronal cell loss in PSP is unknown and treatment options are consequently limited. However, converging lines of evidence from the distinct neurodegenerative conditions of PD and amyotrophic lateral sclerosis (ALS) are beginning to provide insights into potential commonalities in PSP pathology and opportunity for novel therapeutic intervention. These include accumulation of the high abundance cuproenzyme superoxide dismutase 1 (SOD1) in an aberrant copper‐deficient state, associated evidence for altered availability of the essential micronutrient copper, and evidence for neuroprotection using compounds that can deliver available copper to the central nervous system. Herein, we discuss the existing evidence for SOD1 pathology and copper imbalance in PSP and speculate that treatments able to provide neuroprotection through manipulation of copper availability could be applicable to the treatment of PSP.image
Association between higher duodenal levels of the fructose carrier glucose transporter‐5 and nonalcoholic fatty liver disease and liver fibrosis
Authors: De Vito Francesca , Suraci Evelina , Marasco Raffaella , Luzza Francesco , Andreozzi Francesco , Sesti Giorgio , Fiorentino Teresa Vanessa 
Published: October 2023

AbstractBackgroundAn increased dietary fructose intake has been shown to exert several detrimental metabolic effects and contribute to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). An augmented intestinal abundance of the fructose carriers glucose transporter‐5 (GLUT‐5) and glucose transporter‐2 (GLUT‐2) has been found in subjects with obesity and type 2 diabetes. Herein, we investigated whether elevated intestinal levels of GLUT‐5 and GLUT‐2, resulting in a higher dietary fructose uptake, are associated with NAFLD and its severity.MethodsGLUT‐5 and GLUT‐2 protein levels were assessed on duodenal mucosa biopsies of 31 subjects divided into 2 groups based on ultrasound‐defined NAFLD presence who underwent an upper gastrointestinal endoscopy.ResultsIndividuals with NAFLD exhibited increased duodenal GLUT‐5 protein levels in comparison to those without NAFLD, independently of demographic and anthropometric confounders. Conversely, no difference in duodenal GLUT‐2 abundance was observed amongst the two groups. Univariate correlation analyses showed that GLUT‐5 protein levels were positively related with body mass index, waist circumference, fasting and 2 h post‐load insulin concentrations, and insulin resistance (IR) degree estimated by homeostatic model assessment of IR (r = 0.44; p = 0.02) and liver IR (r = 0.46; p = 0.03) indexes. Furthermore, a positive relationship was observed between duodenal GLUT‐5 abundance and serum uric acid concentrations (r = 0.40; p = 0.05), a product of fructose metabolism implicated in NAFLD progression. Importantly, duodenal levels of GLUT‐5 were positively associated with liver fibrosis risk estimated by NAFLD fibrosis score.ConclusionIncreased duodenal GLUT‐5 levels are associated with NAFLD and liver fibrosis. Inhibition of intestinal GLUT‐5‐mediated fructose uptake may represent a strategy for prevention and treatment of NAFLD.
Social media use and paediatric practice: Hippocratic help, hype or harm?
Authors: Preisz Anne 
Published: October 2023

Social media is increasingly a part of our personal and professional life and is here to stay. Here, I reflect on issues surrounding the use of social media (SMU) in the digital health context by clinicians in Australian paediatric health care. I aim to briefly highlight some inherent multifactorial and contextual ethical considerations which mainly relate to professionalism; including boundaries, obligations to patients and families within the therapeutic alliance, and balancing the help, hype and harm of SMU in clinical practice. I conclude that digital health and SMU are ubiquitous, and can be beneficial if used circumspectly with Hippocratic principles that have been updated for the modern era and are grounded in ancient moral codes. Unfettered SMU however, without adherence to ethical and legal guidelines is problematic, and may expose patients, families and clinicians to significant risk of harm and moral vulnerability. Justifiable, explicit, consistent and regularly reviewed boundaries, both professional and personal, are ethically advisable. These should reflect, and adapt to, the rapidly evolving nature of social media as imprudent digital health and SMU without proportionate limits, may undermine still relevant Hippocratic tenets, and the primacy of doing no harm.
Prognostic factors and outcome in cats with thymic epithelial tumours: 64 cases (1999‐2021)
Authors: Marks T. A. , Rossanese M. , Yale A. D. , Stewart S. , Smallwood K. , Rigas K. , Guillén A. 
Published: October 2023

ObjectivesTo describe the clinical presentation, treatment and outcomes of cats diagnosed with thymic epithelial tumours and to determine prognostic factors for survival and recurrence.Materials and MethodsClinical records of cats diagnosed with a thymic epithelial tumour between 1999 and 2021 at three referral institutions were retrospectively reviewed.ResultsSixty‐four cats were included. Paraneoplastic syndromes were present in nine cats and metastatic disease was seen in two cats, one at diagnosis and one at the time of recurrence. Median tumour diameter was 6 cm (range, 2 to 15) and a cystic appearance was described on imaging in 25 cats. Surgical excision was attempted in 54 cats with a perioperative mortality rate of 11%.Median survival time for cats surviving to hospital discharge was 897 days (range, 21 to 3322). The 1‐, 2‐ and 5‐year survival rates for surgically treated thymic epithelial tumour were 86%, 70% and 66%, respectively. Survival was longer for cats with Masaoka‐Koga stage I and II tumours compared to stages III and IV (1366 days versus 454 days; P=0.002). Masaoka‐Koga stage was the only significant prognostic factor detected on multi‐variable analysis, with stage III and IV tumours associated with increased risk of death (hazard ratio: 5.67, 95% confidence interval: 1.29 to 24.91, P=.021). Tumour recurrence occurred in 11 cats at a median of 564 days (range, 93 to 1095); no significant prognostic factors for recurrence were identified.Clinical SignificanceCats with thymic epithelial tumours had a good long‐term prognosis following surgery. Tumour recurrence can occur late in the disease course and ongoing monitoring should therefore be considered. Masaoka‐Koga stage may influence survival time and could be used to predict outcome.
Storage of spinach juice agglomerates: Physical, flow, structural, and thermal properties
Authors: Çalışkan Koç Gülşah , Yüksel Sarıoğlu Hira , Dirim Safiye Nur , Pandiselvam Ravi 
Published: October 2023

AbstractThe objective of this study was to investigate how the various storage temperatures affected the physical properties, flow characteristics, microstructure, and glass transition temperature of spinach juice agglomerates. For this purpose, spray‐dried spinach juice powders were processed to agglomerates by using a modified fluidized bed dryer (1.6 m/s airflow rate, 60°C drying air temperature, 20 min processing time, and with different binder solutions containing agents as maltodextrin, gum Arabic, and whey powder isolate). The analyses were carried out every month throughout 6 months while the spinach juice agglomerates were stored at temperatures of 4, 20, and 35°C. The results revealed that over the storage time, the moisture content and water activity values of the agglomerates were generally under 11% and 0.6, respectively. The color values generally showed a decreasing trend depending on the storage time. The solubility times of the samples stored at 4°C were longer than those of stored at other storage temperatures. The SJA‐GA had the lowest HR and CI values and thus the best flowability properties during all storage times. There was no detectable change in the structures of SJA stored at 20°C according to the storage time. Throughout the storage time, it was discovered that the glass transition temperature of all spinach juice agglomerates was remarkably similar. Overall, the investigation revealed that storage at 35°C for 6 months might be suitable because it delivered the intended outcomes such as greater flowability and cohesiveness, and shorter wettability and solubility times.