bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain-Age Prediction: Systematic Evaluation of Site Effects, and Sample Age Range and Size
Authors: Yu Yuetong , Cui Hao-Qi , Haas Shalaila S. , New Faye , Sanford Nicole , Yu Kevin , Zhan Denghuang , Yang Guoyuan , Gao Jia-Hong , Wei Dongtao , Qiu Jiang , Bernhardt Boris , Thompson Paul , Frangou Sophia , Ge Ruiyang ,   ENIGMA World Aging Center
Published: November 2023

ABSTRACTStructural neuroimaging data have been used to compute an estimate of the biological age of the brain (brain-age) which has been associated with other biologically and behaviorally meaningful measures of brain development and aging. The ongoing research interest in brain-age has highlighted the need for robust and publicly available brain-age models pre-trained on data from large samples of healthy individuals. To address this need we have previously released a developmental brain-age model. Here we expand this work to develop, empirically validate, and disseminate a pre-trained brain-age model to cover most of the human lifespan. To achieve this, we selected the best-performing model after systematically examining the impact of site harmonization, age range, and sample size on brain-age prediction in a discovery sample of brain morphometric measures from 35,683 healthy individuals (age range: 5-90 years; 53.59% female). The pre-trained models were tested for cross-dataset generalizability in an independent sample comprising 2,101 healthy individuals (age range: 8-80 years; 55.35% female) and for longitudinal consistency in a further sample comprising 377 healthy individuals (age range: 9-25 years; 49.87% female). This empirical examination yielded the following findings: (1) the accuracy of age prediction from morphometry data was higher when no site harmonization was applied; (2) dividing the discovery sample into two age-bins (5-40 years and 40-90 years) provided a better balance between model accuracy and explained age variance than other alternatives; (3) model accuracy for brain-age prediction plateaued at a sample size exceeding 1,600 participants. These findings have been incorporated into CentileBrain [https://centilebrain.org/#/brainAGE2], an open-science, web-based platform for individualized neuroimaging metrics.
Reported harassment and mental-ill health in a Canadian prospective cohort of women and men in welding and electrical trades
Authors: Galarneau Jean-Michel , Durand-Moreau Quentin , Cherry Nicola 
Published: November 2023

AbstractIntroductionExperience of psychosocial environments by workers entering trade apprenticeships may differ by gender. We aimed to document perceived harassment and to investigate whether this related to mental ill-health.MethodsCohorts of workers in welding and electrical trades were established, women recruited across Canada and men from Alberta. Participants were re-contacted every six months for up to 3 years (men) or 5 years (women). At each contact they were asked about symptoms of anxiety and depression made worse by work. After their last regular contact participants received a ‘wrap-up’ questionnaire that included questions on workplace harassment. In Alberta respondents who consented were linked to the administrative health database which recorded diagnostic codes for each physician contact.Results1885 workers were recruited, 1001 in welding trades (447 women) and 884 in electrical trades (438 women). 1419 (75.3%) completed a ‘wrap up’ questionnaire, with 1413 answering questions on harassment. 60% of women and 32% of men reported that they had been harassed. Those who reported harassment had more frequently recorded episodes of anxiety and depression made worse by work in prospective data. In Alberta 1242 were successfully matched to administrative health records. Those who reported harassment were more likely to have a physician record of depression since starting in their trade.ConclusionsTradeswomen were much more likely than tradesmen to recall incidents of harassment. The results from record linkage, and from prospectively-collected reports of anxiety and depression made worse by work, support a conclusion that harassment resulted in poorer mental health.What is important about this paper?In this study we show that the majority of women entering the male-dominated trades of welding and electrical work report harassment, particularly during their apprenticeship, that is largely from co-workers and has a sexual component. Through its longitudinal design and linkage to an administrative health database, the study has reduced the impact of reporting bias and produced credible evidence that reported harassment is associated with anxiety and depression made worse by work and with physician reported depression. There is increasing recognition that workplace harassment of any worker is unacceptable, with obligations on the employer to take action to eliminate it. Evidence of ongoing mental health impacts reinforces this obligation.
Incorporation of multiple β2-backbones into a proteinin vivousing an orthogonal aminoacyl-tRNA synthetase
Authors: Hamlish Noah X. , Abramyan Ara M. , Schepartz Alanna 
Published: November 2023

AbstractSynthesis of sequence-defined biomaterials whose monomer backbones diverge from canonical α-amino acids represents the next frontier in protein and biomaterial evolution with the potential to yield better biological therapeutics, bioremediation tools, and biodegradable plastic-like materials. One monomer family of particular interest for biomaterials are β-hydroxy acids. Many natural products contain isolated β-esters, and polymeric β-esters are found in polyhydroxyalkanoate (PHA) polyesters under development as bioplastics and drug encapsulation/delivery systems. Here we report that β2-hydroxy acids possessing both(R)and(S)absolute configuration are excellent substrates for pyrrolysyl-tRNA synthetase (PylRS) enzymesin vitro, and that(S)-β2-hydroxy acids are substratesin cellulo. Using theMaPylRS/MatRNAPylpair, in conjunction with wild-typeE. coliribosomes and EF-Tu, we report the cellular synthesis of model proteins containing two(S)-β2-hydroxy acid residues at internal positions. Metadynamics simulations provide a rationale for the observed enantioselective preference of the ribosome for the(S)-β2-hydroxy acid backbone and mechanistic insights that inform future ribosomal engineering efforts. As far as we know, this finding represents the first example of an orthogonal synthetase that accepts a β-backbone substrate and the first example of a protein hetero-oligomer containing multiple expanded-backbone monomers producedin cellulo.
CRISPR/Cas9-based disease modelling and functional correction of Interleukin 7 Receptor alpha Severe Combined Immunodeficiency in T-lymphocytes and hematopoietic stem cells
Authors: Rai Rajeev , Steinberg Zohar , Romito Marianna , Zinghirino Federica , Hu Yi-Ting , White Nathan , Naseem Asma , Thrasher Adrian J , Turchiano Giandomenico , Cavazza Alessia 
Published: November 2023

ABSTRACTInterleukin 7 Receptor α Severe Combined Immunodeficiency (IL7R-SCID) is a life-threatening disorder caused by homozygous mutations in theIL7RAgene. Defective IL7R expression in humans hampers T cell precursors proliferation and differentiation during lymphopoiesis resulting in absence of T cells in newborns, who succumb to severe infections and death early after birth. Previous attempts to tackle IL7R-SCID by viral gene therapy have shown that unregulated IL7R expression predisposes to leukaemia, suggesting the application of targeted gene editing to insert a correct copy of theIL7RAgene in its genomic locus and mediate its physiological expression as a more feasible therapeutic approach. To this aim, we have first developed a CRISPR/Cas9-based IL7R-SCID disease modelling system that recapitulates the disease phenotype in primary human T cells and hematopoietic stem and progenitor cells (HSPCs). Then, we have designed a knock-in strategy that targetsIL7RAexon 1 and introduces via homology directed repair a corrective, promoterless IL7RA cDNA followed by a reporter cassette through AAV6 transduction. Targeted integration of the corrective cassette in primary T cells restored IL7R expression and rescued functional downstream IL7R signalling. When applied to HSPCs further induced to differentiate into T cells in an Artificial Thymic Organoid system, our gene editing strategy overcame the T cell developmental block observed in IL7R-SCID patients, while promoting full maturation of T cells with physiological and developmentally regulated IL7R expression. Finally, genotoxicity assessment of the CRISPR/Cas9 platform in HSPCs using biased and unbiased technologies confirmed the safety of the strategy, paving the way for a new, efficient, and safe therapeutic option for IL7R-SCID patients.
Generating and testing reagents for CRISPR/Cas9 based homologous recombination and gene drive inTribolium
Authors: Markley Hannah C. , Helms Kennedy J. , Maar Megan , Zentner Gabriel E. , Wade Michael J. , Zelhof Andrew C. 
Published: November 2023

AbstractCRISPR/Cas9 gene drive systems are possible in a few insects and ever expanding. Nonetheless, success in one species and techniques developed for it are not necessarily applicable to other species. As such, the development and expansion of gene drive systems is dependent upon direct experimentation. A critical aspect and potentially limiting factor of gene drive is the ability to induce Cas9-dependent homologous recombination. Here we report our attempts to induce Cas9-dependent homologous recombination and subsequent gene drive inTribolium castaneum. Utilizing constructs containing one or two target gRNAs in combination with Cas9 under two different promoters and corresponding homology arms, we found a high incidence of CRISPR/Cas9 induced mutations but a complete lack of evidence of homologous recombination and genetic drive. Even though the generated constructs provide new resources for CRISPR/Cas9 modification of theTriboliumgenome, our results suggest thatTriboliumgenome may be refractory towards Cas9-induced homologous recombination and additional modifications will be necessary to increase the potential for homologous recombination.
Detection of a Mitochondrial Stress Phenotype using the Cell Painting Assay
Authors: Adariani Soheila Rezaei , Agne Daya , Koska Sandra , Burhop Annina , Warmers Jens , Janning Petra , Metz Malte , Pahl Axel , Sievers Sonja , Waldmann Herbert , Ziegler Slava 
Published: November 2023

AbstractMitochondria are cellular powerhouses and crucial for cell function. However, these organelles are vulnerable to internal and external perturbagens that may impair mitochondrial function and eventually lead to cell death. In particular, small molecules may impact mitochondrial function and cardio- or hepatotoxicity caused by numerous drugs links mitochondrial toxicity to these adverse effects. Therefore, the influence of small molecules on mitochondrial homeostasis is at best assessed early on in the characterization of biologically active small molecules and drug discovery. We demonstrate that unbiased morphological profiling by means of the Cell Painting assay (CPA) can detect mitochondrial stress coupled to the induction of integrated stress response. This activity is common for compounds addressing different targets, is not shared by direct inhibitors of the electron transport chain and enables prediction of mitochondrial stress induction for small molecules that are profiled using CPA.
Do the young employees perceive themselves as digitally competent and does it matter?
Authors: Tomczak Michał T. , Ziemiański Paweł , Gawrycka Małgorzata 
Published: November 2023

PurposeThe study aims to examine the digital competence of young employees (under 30 years of age) who graduated from the technical university. Self-assessment of selected digital competencies was examined along with the determination of a self-efficacy level in the area of using digital competencies.Design/methodology/approachQuantitative research was conducted using the computer-assisted web interview method on a sample of 4532 respondents.FindingsYoung employees' self-assessment of digital competencies and self-efficacy in the area of using them is high, and it can be assumed that they perceive themselves as digitally competent. Both digital self-efficacy and assessed digital competencies have a positive impact on satisfaction with the university.Research limitations/implicationsThe research sample consisted only of employees who graduated from the technical university, but the results may provide feedback on the demand for digital competencies sought in the labor market and constitute valuable information useful in university curriculum development and in vocational education and training.Originality/valueThis is the first study that focuses on the Kozanoglu and Abedin approach to the concept of digital literacy in the context of research on self-assessment and self-efficacy in using digital competencies among technical university graduates, adapting the creative self-efficacy scale by Tierney and Farmer, for measuring digital self-efficacy.Highlights/value Young employees' digital competencies self-assessment is high.Young employees' self-efficacy of using digital competencies is high.Graduating from a DT-focused department has a positive impact on satisfaction.Digital self-efficacy has a positive impact on satisfaction with the university.Assessed digital competencies have a positive impact on satisfaction.
The Social Drivers of Inclusive Workplaces scale: a preliminary validation of the questionnaire
Authors: Santarpia Ferdinando Paolo , Sommovigo Valentina , Borgogni Laura 
Published: November 2023

PurposeDrawing on Shore and colleagues' model of inclusive workplaces (2018) and the perceptions of social context framework (Borgogniet al., 2010), this study aims to develop and provide a preliminary validation of the Social Drivers of Inclusive Workplaces (SDIW) scale.Design/methodology/approachUsing inductive and deductive approaches, items were developed. The resulting pool of 28 items was administrated to 1,244 employees using an anonymous online survey. The factor structure of the SDIW scale was tested through exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Reliabilities were estimated. Alternative models were tested through CFAs. Nomological validity and measurement invariance across gender were explored.FindingsThe EFA revealed a three-factor structure, including inclusive colleagues, supervisors and top management. This solution was confirmed by the CFA and outperformed all alternative models, showing good reliabilities. Measurement invariance across gender was confirmed. Correlations indicated that the SDIW total score and each dimension were positively associated with belongingness needs satisfaction and affective commitment, while negatively related to interpersonal strain, negative acts and turnover intention.Practical implicationsThis study provides practitioners with a reliable tool to map social drivers of inclusion within workplaces in order to design tailored interventions.Originality/valueThis study contributes to the inclusion literature, as it is the first to provide a scale that simultaneously measures employees' perceptions of inclusive behaviours enacted by the three main social actors within the workplace.
Meesho: reselling in the grocery or e-commerce segment?
Authors: Purohit Sonal 
Published: November 2023

Learning outcomes
The learning outcomes of this case study are as follows: to understand the concept of social commerce and how it is different from e-commerce business, to discuss the unique features of Meesho’s social commerce model, to understand concepts of entrepreneurship (e.g. addressing the gap through business, pivoting), to understand the dynamics of online grocery market and e-commerce market and to apply business strategy concepts to make recommendations.

Case overview/synopsis
This case study presents Meesho, an organization in social commerce in India. Meesho was founded by Indian Institute of Technology graduates Vidit Aatrey and Sanjeev Barnwal in the year 2015 to help the small business owners with online selling. It was initially launched as an app that connected local retailers to the customers. Owing to low customer interest and low profit margins, they pivoted the business to a reseller app that facilitated the individuals and small retailers to resell the wholesalers’ products (unbranded and long-tail products) to the customers on social media channels. However, the tough competition from other start-ups in social commerce and retail giants such as Amazon and Flipkart who targeted the same customers impacted their growth. After receiving a funding of US$300m, the founders were considering if they should enter the e-commerce market and directly compete with giants such as Amazon and Flipkart or extend the product line to the online groceries market and compete with dominant players such as BigBasket and Blinkit. Through this case study, the students could be provided an opportunity to evaluate a situation, apply the strategic management concepts and make a recommendation on the strategic plan.

Complexity academic level
The case study can be taught in the business and strategy courses at the graduate and postgraduate levels in business schools. It is also suitable for the entrepreneurship course with focus on e-commerce start-up and sustainability, which is also taught at the MBA level. This case study can also be used in executive development programs for abovementioned courses.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy.
Factors influencing career advancement in supply chain management with gender perspectives: French case study
Authors: Kafa Nadine , Ruel Salomée , Jaegler Anicia 
Published: November 2023

PurposeThe field of supply chain management (SCM) needs to attract and retain workers to solve the current talent shortage. The purpose of this research is to identify and evaluate factors that influence career advancement in SCM and compare male and female supply chain experts' perceptions of the importance of those factors.Design/methodology/approachFirst, 32 factors perceived as affecting career advancement in SCM were identified by conducting a literature review and consulting 36 experts. Those factors were grouped into four categories: “environmental and structural”, “human capital”, “individual” and “interpersonal”. Those factors were validated via the Delphi method, and ten factors were retained for further study. Second, the voting analytical hierarchy process was used to determine the priority weights experts assigned to these factors. The weights assigned by male and female experts were compared to determine if there were differences between the women's and men's perceptions of the factors' importance.FindingsThe findings reveal that the category of human capital factors is the most important, followed by individual factors and the least important is interpersonal factors. The experts consulted for this research emphasized “skills”, “a good fit between an individual and an organization” and “self-confidence” as important factors for career advancement. There were two unexpected results. First, the experts rejected all the environmental and structural factors. Second, no significant difference was found between the male and female groups' evaluations.Originality/valuePrior to this study, no integrated approach to identify and evaluate the factors perceived which affect career advancement in SCM had been developed. This research is a single empirical and integrative study in France that provides valuable insights for academics and practitioners.
Circular service management: toward conceptual understanding and service research priorities for a more sustainable future
Authors: Karpen Ingo Oswald , Edvardsson Bo , Tronvoll Bård , Jaakkola Elina , Conduit Jodie 
Published: November 2023

PurposeService managers increasingly strive to achieve sustainability through strategies centered on circularity. With a focus on saving, extending and (re)generating resources and their enclosing service systems, circularity can contribute to environmental, social and financial gains. Yet, the notion of circularity is surprisingly understudied in service research. This article seeks to provide an initial conceptual understanding of circular service management, introducing illustrative strategies and research priorities for circular service management. This paper provides a roadmap for scholars, practitioners and policymakers to develop a deeper understanding of the opportunities from adopting circular services.Design/methodology/approachThe authors explore the concept of circular service management by drawing upon existing literature on sustainability, circularity and service research. Strategies of circular service management and research priorities emerge on the basis of industry best practice examples and research on sustainability challenges and opportunities.FindingsService researchers have largely ignored the concept and role of circularity for service businesses. Extant research on the topic nearly exclusively features in non-service journals and/or does not seek to advance service theory through circularity. This article argues that circular service management enables the implementation of service thinking in the pursuit of sustainability and outlines four types of circular service management strategies.Originality/valueThe authors introduce the concept of circular service management and highlight the role of service research for designing and managing circular systems and operations. This article also offers a research agenda connecting managerial challenges and opportunities with key service research priorities for circular service management. This provides a roadmap for scholars, practitioners and policymakers to develop a deeper understanding of pursuing circular services, thereby contributing to a more sustainable future.
Uncovering the trends and developments in subscription business models through bibliometric analysis
Authors: Sharma Yogesh , Sijariya Rajeev 
Published: November 2023

PurposeThe purpose of this study is to examine the trends and developments of subscription business models (SBMs) over the past two decades.Design/methodology/approachThe study extracted 469 documents (articles and reviews) from the Scopus database during 2000–2022 and analysed 132 documents (articles and reviews). A bibliometric methodology of scientific mapping was employed, including a cluster analysis based on the bibliographic coupling of documents. Content analysis was also conducted to reveal emerging trends in SBMs.FindingsThe study revealed six emerging themes in SBMs related to consumer behaviour, digital advertising, online news media, journal publications, circular economy and sustainability strategies.Originality/valueThe results of this study provide new and unique insights into the development and trends of SBMs over the past two decades and offer guidance for future researchers to investigate further the phenomenon of SBMs in emerging areas.