bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Versus Dilational Tracheostomy in Patients with Severe Stroke: A SETPOINT2 Post hoc Analysis
Authors: Schneider Hauke , Meis Jan , Klose Christina , Ratzka Peter , Niesen Wolf-Dirk , Seder David B. , Bösel Julian ,   for the SETPOINT2 and IGNITE study groups
Published: January 2024

Abstract
Background
Tracheostomy in mechanically ventilated patients with severe stroke can be performed surgically or dilationally. Prospective data comparing both methods in patients with stroke are scarce. The randomized Stroke-Related Early Tracheostomy vs Prolonged Orotracheal Intubation in Neurocritical Care Trial2 (SETPOINT2) assigned 382 mechanically ventilated patients with stroke to early tracheostomy versus extubation or standard tracheostomy. Surgical tracheostomy (ST) was performed in 41 of 307 SETPOINT2 patients, and the majority received dilational tracheostomy (DT). We aimed to compare ST and DT in these patients with patients.

Methods
All SETPOINT2 patients with ST were compared with a control group of patients with stroke undergoing DT (1:2), selected by propensity score matching that included the factors stroke type, SETPOINT2 randomization group, Stroke Early Tracheostomy score, patient age, and premorbid functional status. Successful decannulation was the primary outcome, and secondary outcome parameters included functional outcome at 6 months and adverse events attributable to tracheostomy. Potential predictors of decannulation were evaluated by regression analysis.

Results
Baseline characteristics were comparable in the two groups of patients with stroke undergoing ST (n = 41) and matched patients with stroke undergoing DT (n = 82). Tracheostomy was performed significantly later in the ST group than in the DT group (median 9 [interquartile range {IQR} 5–12] vs. 9 [IQR 4–11] days after intubation, p = 0.025). Patients with ST were mechanically ventilated longer (median 19 [IQR 17–24] vs.14 [IQR 11–19] days, p = 0.008) and stayed in the intensive care unit longer (median 23 [IQR 16–27] vs. 17 [IQR 13–24] days, p = 0.047), compared with patients with DT. The intrahospital infection rate was significantly higher in the ST group compared to the DT group (14.6% vs. 1.2%, p = 0.002). At 6 months, decannulation rates (56% vs. 61%), functional outcomes, and mortality were not different. However, decannulation was performed later in the ST group compared to the DT group (median 81 [IQR 66–149] vs. 58 [IQR 32–77] days, p = 0.004). Higher baseline Stroke Early Tracheostomy score negatively predicted decannulation.

Conclusions
In ventilated patients with severe stroke in need of tracheostomy, surgical and dilational methods are associated with comparable decannulation rate and functional outcome at 6 months. However, ST was associated with longer time to decannulation and higher rates of early infections, supporting the dilational approach to tracheostomy in ventilated patients with stroke.
Primary Care Considerations for the Pediatric Endurance Athlete
Authors: Watkins Rhonda A. , Guillen Rafael Verduzco 
Published: January 2024

Abstract
Purpose of Review
This study aimed to provide an overview of some of the medical concerns surrounding the care of the pediatric endurance athletes and add to the limited literature specific to the pediatric endurance athlete.

Recent Findings
Endurance athletes are at risk for overtraining, relative energy deficiency in sport (RED-S), overuse injuries, nutritional deficiencies, and sleep dysfunction. Youth runners and female endurance athletes are particularly high-risk populations for RED-S; nutritional deficiencies and their care should involve thoughtful mitigation of modifiable risk factors. The growing endurance athlete may experience slightly different cardiac adaptations than the adult endurance athlete with the long-term implications of these changes still unclear.

Summary
Endurance sports are common among youth athletes. Multidisciplinary care that includes screening and early intervention for high-risk areas is critical to optimize their care and promote, safe lifelong sport participation.
Myosin Va-dependent Transport of NMDA Receptors in Hippocampal Neurons
Authors: Gong Ru , Qin Linwei , Chen Linlin , Wang Ning , Bao Yifei , Lu Wei 
Published: January 2024

AbstractN-methyl-D-aspartate receptor (NMDAR) trafficking is a key process in the regulation of synaptic efficacy and brain function. However, the molecular mechanism underlying the surface transport of NMDARs is largely unknown. Here we identified myosin Va (MyoVa) as the specific motor protein that traffics NMDARs in hippocampal neurons. We found that MyoVa associates with NMDARs through its cargo binding domain. This association was increased during NMDAR surface transport. Knockdown of MyoVa suppressed NMDAR transport. We further demonstrated that Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates NMDAR transport through its direct interaction with MyoVa. Furthermore, MyoVa employed Rab11 family-interacting protein 3 (Rab11/FIP3) as the adaptor proteins to couple themselves with NMDARs during their transport. Accordingly, the knockdown of FIP3 impairs hippocampal memory. Together, we conclude that in hippocampal neurons, MyoVa conducts active transport of NMDARs in a CaMKII-dependent manner.
Individual aerodynamic and physiological data are critical to optimise cycling time trial performance: one size does not fit all
Authors: Faulkner Steve H. , Jobling Philippa , Griggs Katy E. , Siegkas Petros 
Published: January 2024

AbstractCycling time trials are characterised by riders adopting positions to lessen the impact of aerodynamic drag. Aerodynamic positions likely impact the power a rider is able to produce due to changes in oxygen consumption, blood flow, muscle activation and economy. Therefore, the gain from optimising aerodynamics must outweigh the potential physiological cost. The aim was to establish the relationship between energy expenditure and aerodynamic drag, with a secondary aim to determine the reliability of a commercially available handlebar mounted aero device for measuring aerodynamic drag. Nine trained male cyclists volunteered for the study. They completed 4 × 3200 m on an outdoor velodrome where stack height was adjusted in 1 cm integers. The drag coefficient (CdA), oxygen consumption and aerodynamic-physiological economy (APE) were determined at each stack height, with data used to model 40 km TT performance. Small to moderate effect sizes (ES) in response to stack height change were found for CdA, APE and energy cost. The change in TT time was correlated to ∆aerodynamic drag and ∆APE. Meaningful impacts of change in stack height on CdA, APE, energy cost and predicted TT performance, are apparent with highly individualised responses to positional changes.
Pulsed field versus cryoballoon ablation for atrial fibrillation: a real-world observational study on procedural outcomes and efficacy
Authors: van de Kar Mileen R. D. , Slingerland Stacey R. , van Steenbergen Gijs J. , Brouwer Tim , Schulz Daniela N. , van Veghel Dennis , Dekker Lukas 
Published: January 2024

Abstract
Introduction
Atrial fibrillation often necessitates catheter ablation when antiarrhythmic drug therapy fails. Single-shot technologies using thermal energy, such as cryoballoon ablation, are commonly used, but pulsed field ablation (PFA), an innovative non-thermal ablation technique, is a potential alternative. This retrospective observational study aimed to compare the safety and efficacy of cryoballoon ablation and PFA in patients undergoing their first pulmonary vein isolation (PVI) procedure for atrial fibrillation treatment.

Methods
We utilised real-world data from patients who underwent PVI using cryoballoon ablation or PFA. The primary outcome encompassed procedural complications, including phrenic nerve palsy, cardiac tamponade, thromboembolic complications, bleeding complications and mortality. Secondary outcomes were procedural characteristics including procedure duration, length of hospital admission, and re-do ablation rates within 6 months.

Results
A total of 1714 procedures were analysed: 1241 in the cryoballoon group and 473 in the PFA group. Gender distribution (p = 0.03) and estimated glomerular filtration rate (p = 0.01) differed significantly. With regard to the primary outcome, the cryoballoon group demonstrated a higher incidence of phrenic nerve palsy compared with the PFA group (15 vs 0; p = 0.02). The procedure duration was shorter in the PFA group, even after adjusting for baseline characteristics (95.0 vs 74.0 min; p < 0.001). After adjustment for baseline characteristics, admission duration differed between the groups as well (p = 0.04).

Conclusion
The study results supported the safety and efficacy of PFA over cryoballoon ablation for PVI, highlighting advantages such as shorter procedure duration and absence of phrenic nerve palsy.
Options to reduce ranges in critical soil nutrient levels used in fertilizer recommendations by accounting for site conditions and methodology: A review
Authors: Siatwiinda Siatwiinda M. , Ros Gerard H. , Yerokun Olusegun A. , de Vries Wim 
Published: January 2024

AbstractFertilizer recommendations (FR) to improve yields and increase profitability are based on relationships between crop yields and soil nutrient levels measured via soil extraction methods. Within these FR, critical soil nutrient (CSN) levels are used to distinguish nutrient deficient from non-deficient soils. The variation in CSN levels is large, implying a risk of over- or under-fertilization. Here, we review and assess the factors influencing the derivation of CSN levels in order to increase both their reliability and applicability within FR systems. The evaluated factors included site conditions, i.e., crop type and location as a surrogate for climate and soil properties, and methodological factors, i.e., the experimental approach (field or pot experiments), and statistical methods and cut-off point. Results showed that the range of values used to define the medium soil fertility classes coincided with the range of CSN levels derived from experimental data. We show that harmonizing methodological aspects can substantially reduce the uncertainty in the CSN levels (> 50%), implying a substantial enhancement of the reliability of FR systems. Inclusion of site conditions might further improve the reliability. To enable reduction in CSN levels requires well-documented field experiments and standardization of data collection and analysis. We foresee the potential for generic FR systems that make use of reliable data, more process-based interpretation of nutrient pools and accounting for the interactions among nutrients.
A sustainable clean energy source for mitigating CO2 emissions: numerical simulation of Hamit granitoid, Central Anatolian Massif
Authors: Ayzit Tolga , Singh Mrityunjay , Chandrasekharam Dornadula , Baba Alper 
Published: January 2024

AbstractTürkiye relies on coal-fired power plants for approximately 18 GW of annual electricity generation, with significantly higher CO2 emissions compared to geothermal power plants. On the other hand, geothermal energy resources, such as Enhanced Geothermal Systems (EGS) and hydrothermal systems, offer low CO2 emissions and baseload power, making them attractive clean energy sources. Radiogenic granitoid, with high heat generation capacity, is a potential and cleaner energy source using EGS. The Anatolian plateau hosts numerous tectonic zones with plutonic rocks containing high concentrations of radioactive elements, such as the Central Anatolian Massif. This study evaluates the power generation capacity of the Hamit granitoid (HG) and presents a thermo-hydraulic-mechanical (THM) model for a closed-loop geothermal well for harnessing heat from this granitoid. A sensitivity analysis based on fluid injection rates and wellbore length emphasizes the importance of fluid resident time for effective heat extraction. Closed-loop systems pose fewer geomechanical risks than fractured systems and can be developed through site selection, system design, and monitoring. Geothermal wellbore casing material must withstand high temperatures, corrosive environments, and should have low thermal conductivity. The HG exhibits the highest heat generation capacity among Anatolian granitoid intrusions and offers potential for sustainable energy development through EGS, thereby reducing CO2 emissions.
Provision and Long-Term Assessment of a Specialized Clinical Evidence-Based Practice Curriculum for Master of Social Work Students
Authors: Reay Susan R. 
Published: January 2024

AbstractThis study investigated social workers’ knowledge of the common elements in evidence-based practice to treat youth mental health conditions following a specialized curriculum during their Master of Social Work (MSW) education. Participants’ knowledge was measured during their MSW education and in their first 5 years of social work practice after graduation. The quantitative study measured participants’ knowledge of common elements three times; 86 social workers participated in the study with 67 sets of scores at three data points. Study results showed that participants knew more after completing the curriculum but knew less one to five years after graduation. Overall, however, their knowledge remained higher than before the curriculum. The findings provided insight into social workers’ knowledge of common elements of evidence-based practice modalities over time following a specialized curriculum. Findings also suggested that having multiple work obligations, lacking supervision, and receiving supervision by someone other than a social worker were all factors that might hinder graduates from continuing their education in evidence-based practice after graduation.
Using the Number of N95® Filtering Facepiece Respirator Models as an Indicator of Supply Chain Stability in a US Health-Care System
Authors: Furek Alexa , Edirisooriya Mihili , Casey Megan , Haas Emily J. 
Published: January 2024

Abstract

Objectives:
Personal protective equipment (PPE) supply chain disruptions force US health-care entities to adopt conservation strategies such as procurement from different respirator manufacturers. This research seeks to better understand how the number of respirator models on hand can serve as an indicator of N95 filtering facepiece respirator (FFR) supply chain stability or disruption.

Methods:
Researchers looked at differences in the mean number of N95 FFR models, averaged weekly, from 10 hospitals in a health-care system over 15 wk from June 1 to September 10, 2020. Participating hospitals entered near-daily PPE inventory data by manufacturer and model number.

Results:
A linear mixed effect model was run in SPSS v. 26 using a random intercept for hospitals, with week as a fixed predictor and mean number of respirator models (averaged weekly) on hand as the dependent variable. Each week showed a small but significant effect compared with the past week (P < 0.001), where the average weekly number of respirator models on hand decreased.

Conclusions:
The limited data may indicate a resolution of supply chain disruptions and warrant further investigation. Consequently, the number of respirator models may be applicable as an indicator of supply chain stability and be more easily ascertained and tracked by health-care entities.
Impact of oral vancomycin treatment duration on rate of Clostridioides difficile recurrence in patients requiring concurrent systemic antibiotics
Authors: Kwiatkowski Diana , Marsh Kassandra , Katz Alyson , Papadopoulos John , So Jonathan , Major Vincent J. , Sommer Philip M. , Hochman Sarah , Dubrovskaya Yanina , Arnouk Serena 
Published: January 2024

AbstractBackground:There is a paucity of data guiding treatment duration of oral vancomycin for Clostridiodes difficile infection (CDI) in patients requiring concomitant systemic antibiotics.Objectives:To evaluate prescribing practices of vancomycin for CDI in patients that required concurrent systemic antibiotics and to determine whether a prolonged duration of vancomycin (>14 days), compared to a standard duration (10–14 days), decreased CDI recurrence.Methods:In this retrospective cohort study, we evaluated adult hospitalized patients with an initial episode of CDI who were treated with vancomycin and who received overlapping systemic antibiotics for >72 hours. Outcomes of interest included CDI recurrence and isolation of vancomycin-resistant Enterococcus (VRE).Results:Among the 218 patients included, 36% received a standard duration and 64% received a prolonged duration of treatment for a median of 13 days (11–14) and 20 days (16–26), respectively. Patients who received a prolonged duration had a longer median duration of systemic antibiotic overlap with vancomycin (11 vs 8 days; P < .001) and significantly more carbapenem use and infectious disease consultation. Recurrence at 8 weeks (12% standard duration vs 8% prolonged duration; P = .367), recurrence at 6 months (15% standard duration vs 10% prolonged duration; P = .240), and VRE isolation (3% standard duration vs 9% prolonged duration; P = .083) were not significantly different between groups. Discontinuation of vancomycin prior to completion of antibiotics was an independent predictor of 8-week recurrence on multivariable logistic regression (OR, 4.8; 95% CI, 1.3–18.1).Conclusions:Oral vancomycin prescribing relative to the systemic antibiotic end date may affect CDI recurrence to a greater extent than total vancomycin duration alone. Further studies are needed to confirm these findings.
GENERALISED MUTUALLY PERMUTABLE PRODUCTS AND SATURATED FORMATIONS, II
Authors: BALLESTER-BOLINCHES ADOLFO , MADANHA SESUAI Y. , MUDZIIRI SHUMBA TENDAI M. , PEDRAZA-AGUILERA MARÍA C. 
Published: January 2024

AbstractA group
$G=AB$
is the weakly mutually permutable product of the subgroups A and B, if A permutes with every subgroup of B containing
$A \cap B$
and B permutes with every subgroup of A containing
$A \cap B$
. Weakly mutually permutable products were introduced by the first, second and fourth authors [‘Generalised mutually permutable products and saturated formations’, J. Algebra595 (2022), 434–443] who showed that if
$G'$
is nilpotent, A permutes with every Sylow subgroup of B and B permutes with every Sylow subgroup of A, then
$G^{\mathfrak {F}}=A^{\mathfrak {F}}B^{\mathfrak {F}} $
, where
$ \mathfrak {F} $
is a saturated formation containing
$ \mathfrak {U} $
, the class of supersoluble groups. In this article we prove results on weakly mutually permutable products concerning
$ \mathfrak {F} $
-residuals,
$ \mathfrak {F} $
-projectors and
$\mathfrak {F}$
-normalisers. As an application of some of our arguments, we unify some results on weakly mutually
$sn$
-products.
Selenium accumulation in grains of wheat cultivars grown in selenium-rich areas in China
Authors: Kong Weilin , Noor Hafeez , Ren Aixia , Li Linghong , Ding Pengcheng , Ren Yongkang , Gao Zhiqiang , Sun Min 
Published: January 2024

Summary
Selenium (Se) is an essential micronutrient for human health, and Se concentration of wheat grain in China has no significant relationships with selenium concentration of wheat and with soil organic matter, nitrogen, phosphorus, potassium in the 0–20 cm soil layer. However, a significant indigenous positive correlation was found with soil Se concentration. Field experiments were conducted from 2018 to 2020 to clarify the differences in the Se accumulation in wheat plants grown in Se-rich areas. We used two common wheat (ZM-175, SN-20), two purple wheat (JZ-496, ZM-8555), and two black wheat (YH-161, LH-131) cultivars to investigate changes in Se build-up and transportation in plant organs. The grain Se concentration of six wheat genotypes in Se-rich areas varied between 178 and 179 μg Se kg−1, with organic Se accounting for 87 to 91%. All genotypes had more than 150 μg Se kg−1, the standard Se concentration in grains. Purple grain wheat had the highest total and organic Se concentrations. Purple wheat also exhibited significantly higher Se transfer coefficient in roots, stem and leaves, and glumes, when compared to common wheat. Moreover, purple wheat had the highest Se uptake efficiency (e.g., JZ-496 with 31%) when compared to common wheat and black wheat. Regardless of the color, wheat grains met the Se-enriched criteria (150 μg Se kg−1) when grown in a natural Se-enriched area. Due to higher Se uptake and accumulation, purple wheat grain genotypes, such as JZ-496, are recommended for wheat breeding programs aiming for high Se functional foods.
Clarifying directional dependence among measures of early auditory processing and cognition in schizophrenia: leveraging Gaussian graphical models and Bayesian networks
Authors: Abplanalp Samuel J. , Braff David L. , Light Gregory A. , Joshi Yash B. , Nuechterlein Keith H. , Green Michael F. 
Published: January 2024

AbstractBackgroundResearch using latent variable models demonstrates that pre-attentive measures of early auditory processing (EAP) and cognition may initiate a cascading effect on daily functioning in schizophrenia. However, such models fail to account for relationships among individual measures of cognition and EAP, thereby limiting their utility. Hence, EAP and cognition may function as complementary and interacting measures of brain function rather than independent stages of information processing. Here, we apply a data-driven approach to identifying directional relationships among neurophysiologic and cognitive variables.MethodsUsing data from the Consortium on the Genetics of Schizophrenia 2, we estimated Gaussian Graphical Models and Bayesian networks to examine undirected and directed connections between measures of EAP, including mismatch negativity and P3a, and cognition in 663 outpatients with schizophrenia and 630 control participants.ResultsChain structures emerged among EAP and attention/vigilance measures in schizophrenia and control groups. Concerning differences between the groups, object memory was an influential variable in schizophrenia upon which other cognitive domains depended, and working memory was an influential variable in controls.ConclusionsMeasures of EAP and attention/vigilance are conditionally independent of other cognitive domains that were used in this study. Findings also revealed additional causal assumptions among measures of cognition that could help guide statistical control and ultimately help identify early-stage targets or surrogate endpoints in schizophrenia.
Application of ultrasound multimodal imaging in the prediction of cervical tuberculous lymphadenitis rupture
Authors: Zhao Dan , Feng Na , He Ning , Chu Jie , Shao Yaqin , Zhang Wenzhi 
Published: January 2024

Abstract
Lymph node tuberculosis is particularly common in regions with a high tuberculosis burden, and it has a great risk of rupture. This study aims to investigate the utility of ultrasound multimodal imaging in predicting the rupture of cervical tuberculous lymphadenitis (CTL). 128 patients with unruptured CTL confirmed by pathology or laboratory tests were included. Various ultrasonic image features, including long-to-short-axis ratio (L/S), margin, internal echotexture, coarse calcification, Color Doppler Flow Imaging (CDFI), perinodal echogenicity, elastography score, and non-enhanced area proportion in contrast-enhanced ultrasound (CEUS), were analyzed to determine their predictive value for CTL rupture within a one-year follow-up period. As a result, L/S (P < 0.001), margin (P < 0.001), internal echotexture (P < 0.001), coarse calcification (P < 0.001), perinodal echogenicity (P < 0.001), and the area of non-enhancement in CEUS (P < 0.001) were identified as significant imaging features for predicting CTL rupture. The prognostic prediction showed a sensitivity of 89.29%, specificity of 100%, accuracy of 95.31%, respectively. Imaging findings such as L/S < 2, unclear margin, heterogeneous internal echotexture, perinodal echogenicity changed, and non-enhancement area in CEUS > 1/2, are indicative of CTL rupture, while coarse calcification in the lymph nodes is associated with a favorable prognosis.