bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and construct validity of the ACTIVLIM‐Hemo and Haemophilia Activities List (HAL) questionnaires in individuals with haemophilia
Authors: Lobet Sébastien , Hermans Cedric , Chantrain Valérie‐Anne , Foubert Anthe , Lambert Catherine , Penta Massimo 
Published: February 2024

AbstractObjectiveThe objective of this study is to assess the reliability and construct validity of ACTIVLIM‐Hemo, a newly developed Rasch‐built questionnaire designed to evaluate activity limitations in people with haemophilia (PwH), in comparison with the Haemophilia Activities List (HAL), which was developed using Classical Test Theory.MethodsA total of 130 participants with haemophilia A or B were included. They underwent various assessments, including joint health scoring (HJHS), functional tests (TUG and 2MWT) and completed questionnaires such as the BPI, IPAQ, HAL and ACTIVLIM‐Hemo. Reliability indices and the minimum detectable change (MDC95) were determined for ACTIVLIM‐Hemo and for HAL. Construct validity was evaluated through correlations and multiple linear regression, considering demographic and clinical factors.ResultsBoth ACTIVLIM‐Hemo (Person Separation Index = 0.92) and HAL (Cronbach's α = 0.98) demonstrated high reliability. The MDC95 for ACTIVLIM‐Hemo represented 11.6% of its measurement range, while for HAL, it amounted to 18/100 score points. Activity limitations measured by both instruments were significantly correlated with demographic and clinical factors. Joint health (HJHS), pain severity (BPI) and walking performance (2MWT) emerged as the main predictors of activity limitations, explaining 75% of the variance in ACTIVLIM‐Hemo and 60% in HAL.ConclusionACTIVLIM‐Hemo stands as a reliable and valid instrument for assessing activity limitations in PwH. Both instruments exhibited significant correlations with demographic and clinical factors, but ACTIVLIM‐Hemo displayed a more homogeneous construct. Given its linear scale and lower MDC95 and better targeting, ACTIVLIM‐Hemo shows promise as a patient‐centric instrument for assessing responsiveness to treatment during individual follow‐up.
Canadian clinical experience on switching from standard half‐life recombinant factor VIII (rFVIII), octocog alfa, to extended half‐life rFVIII, damoctocog alfa pegol, in persons with haemophilia A ≥ 12 years followed in a Comprehensive Hemophilia Care Program in Canada
Authors: Matino Davide , Germini Federico , Chan Anthony K. C. , Decker Kay , Iserman Emma , Chelle Pierre , Edginton Andrea N. , Oladoyinbo Olayide , Trinari Elisabetta , Keepanasseril Arun , Iorio Alfonso 
Published: February 2024

AbstractIntroductionDamoctocog alfa pegol (BAY 94–9027, Jivi®) is an extended half‐life recombinant factor (F)VIII replacement, indicated for the treatment of haemophilia A in patients aged ≥12 years. Following introduction of damoctocog alfa pegol in Canada in 2020, there have been no reports on routine clinical effectiveness and satisfaction, when switching from a previous FVIII product in Canada.AimTo report changes in pharmacokinetics, effectiveness, utilization and patient satisfaction when switching to damoctocog alfa pegol prophylaxis from previous standard half‐life octocog alfa (BAY 81–8973, Kovaltry®) treatment.MethodsA single‐centre, intra‐patient comparison of pharmacokinetics and clinical outcomes was performed. Blood samples drawn once pre‐dose and ≥2 times post‐dose were measured by a one‐stage assay to assess pharmacokinetic parameters including area under the curve (AUC, primary endpoint). Patient‐reported outcomes data were collected using the Patient‐Reported Outcomes, Burdens and Experiences questionnaire (PROBE). Clinical outcomes included annualized bleeding rate (ABR) and factor utilization.ResultsDose‐normalized AUC was significantly increased after switch to damoctocog alfa pegol from octocog alfa. Median (quartile [Q]1; Q3) annualized bleeding rates were 0.67 (0.00; 1.33) with damoctocog alfa pegol and 1.33 (0.00; 2.67) with octocog alfa. Half of the patients receiving damoctocog alfa pegol prophylaxis experienced zero bleeds (n = 9, 50.0%) versus 38.9% (n = 7) of patients treated with octocog alfa. Patients’ good quality of life was maintained.ConclusionThis study provides routine clinical evidence supporting the benefits of switching from octocog alfa to damoctocog alfa pegol for patients with severe haemophilia A.
Mentoring and creativity: Resources for working women to thrive in a challenging workplace after COVID‐19
Authors: Sakakibara Keiko 
Published: February 2024

AbstractThis study investigated the association between mentoring and creativity among male and female office workers. A web survey was administered to individuals aged 20–59 years using the survey monitors of an internet company; 2106 valid responses (1048 men and 1058 women) were analyzed to examine the association between mentoring and creativity. A three‐way analysis of covariance was conducted using mentoring, gender, and managerial status as the independent variables, which were adjusted for occupation. The analysis of the main effects showed that mentored individuals had higher creativity than nonmentored individuals, regardless of gender or managerial status. In addition, managers had significantly higher creativity than nonmanagers. There was no significant difference in creativity between men and women. The interaction effect of gender and managerial status was significant, and the analysis of the simple main effects indicated that male nonmanagers had higher creativity than female nonmanagers, whereas no significant gender difference was found between male and female managers. The difference in the creativity score between mentored and nonmentored female managers was 0.467, whereas the difference between mentored and nonmentored male managers was 0.357; this suggests that mentoring is critical, particularly for female managers. The primary focus of mentoring research has been the role of mentoring in promoting career‐related behaviors and attitudes. This study illustrates the potential to enhance creativity, which is an asset for working women in managing challenges after COVID‐19.
Has globalization of the Japanese economy contributed to satisfying career‐building for women? The case of Japanese female migrants to East Asia
Authors: Sakai Chie 
Published: February 2024

AbstractThis paper analyzes the shift in career strategies among Japanese women due to the globalization of Japan's economy since the 1980s. It highlights how economic changes led to a gender‐based division of labor, propelling women to seek opportunities abroad. The research draws on interviews with 81 women who moved to financial centers in East Asia, mainly in Hong Kong and Shanghai, examining their experiences in the workforce, the impact of human resource agencies in their migration, and the challenges and opportunities they encountered. The study reveals a complex landscape where Japanese women navigate gendered expectations and discrimination both in Japan and abroad in pursuit of career advancement. The conclusion emphasizes three points. First, women found opportunities abroad to do what they wanted, even if it was not what they initially expected before leaving Japan. Second, although supportive and subordinate to male managers, their work was indispensable to the management of Japanese companies abroad. Their contribution has long been underestimated but needs to be considered. Third, the experience abroad gave them direct interaction with various clients and colleagues and a view of rapid societal change in Hong Kong and China, contributing to choosing their diverse career trajectories and life plans.
The lupus anticoagulant titer is associated with elevated antiphosphatidylserine/prothrombin immunoglobulin‐M isotype antibody levels
Authors: Saadalla Abdulrahman , Chen Dong , Stuart Melissa , Pruthi Rajiv , Heikal Nahla , Snyder Melissa , Ashrani Aneel , Seheult Jansen 
Published: February 2024

AbstractBackgroundClot based assays used for lupus anticoagulant (LAC) detection are typically interpreted in a qualitative fashion and may not reflect LAC potency. In this cross‐sectional study, we describe a method for quantifying the LAC titer using serial (dependent) two‐fold dilutions in normal pooled plasma.MethodsSerial dilutions of 51 residual plasma samples from 50 patients were tested using the Russell's viper venom screening time (DRVVT) and activated partial thromboplastin screening time (APTT) methodologies. The measured clotting times and the corresponding dilution factors were then used to derive a four‐parameter logistic model. The LAC titer for each patient was interpolated as the sample dilution that corresponds to the upper reference interval limit of the corresponding assay.ResultsCalculated APTT and DRVVT LAC titers displayed a strong linear correlation (R2 = 0.84) between each other, but not with the degree of prolongation of the APTT/DRVVT screening time in the neat undiluted samples. Using data driven partitioning, patients could be grouped into low (<10) or high (≥10) DRVVT LAC titer. There were no significant differences in anticardiolipin (aCL) or anti‐beta 2 glycoprotein 1 (aB2GPI) antibody levels or prevalence of thromboembolic events between low and high LAC titer groups. In contrast, antiphosphatidylserine/prothrombin (aPS/PT) IgM antibody levels, but not IgG, were significantly higher in the high LAC titer group.ConclusionsThe degree of prolongation of the APTT/DRVVT screening time is not correlated with the LAC titer. Only aPS/PT IgM antibodies levels were strongly correlated with the LAC titers. Additional studies are warranted to determine clinical implications of high LAC titers.
Experiences of postpartum Chinese women undergoing confinement practices: A qualitative meta‐synthesis
Authors: Xin Jocelyn Khor Yun , Shian Goh Yong , Han Tan Ting , San Wilson Tam Wai 
Published: February 2024

AbstractAimsWe aim to review the experiences and needs of postpartum Chinese women undergoing ‘confinement’ or ‘doing‐the‐month’ a postpartum practice after childbirth.MethodsA meta‐synthesis was reported in alignment with the Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ) statement. Ten electronic databases were searched for eligible primary qualitative or mixed‐methods studies in English and Chinese from their inception until December 2021. Two reviewers independently reviewed the methodological quality of the included studies using the 10‐item Critical Appraisal Skills Program (CASP) qualitative checklist, with discrepancies resolved through discussions. The meta‐synthesis was conducted based on the two‐step approach by Sandelowski and Barroso.ResultsFour themes were meta‐synthesized from 13 studies: ‘confinement’ as an essential practice; physical and psychological stressors during ‘confinement’; coping strategies by postpartum women; and needs for family, social, and professional support in enhancing satisfaction with ‘confinement’. The review showed that ‘confinement’ remains a significant practice shaped by socio‐cultural and health constructs.ConclusionThis review suggested re‐evaluating the ‘confinement’ practice and promoting evidence‐based care to improve maternal well‐being. Nurses and midwives should be cognisant of such postpartum customs and adopt non‐judgemental attitudes as early as the prenatal period to provide culturally sensitive care.
La falacia de la teoría de la cantidad fija de trabajo. Evidencia empírica de América Latina
Authors: APELLA Ignacio 
Published: February 2024

ResumenEn este artículo se analiza la teoría de la cantidad fija de trabajo con datos empíricos de América Latina en un contexto de envejecimiento demográfico. Las estimaciones con un modelo de efectos fijos sobre un panel de datos anuales de hogares de 2002 a 2019 en 11 países no muestran un efecto de exclusión, sino una correlación positiva entre las tasas de ocupación de los adultos de edad avanzada y de los jóvenes, junto con una asociación positiva entre los ingresos laborales de ambos grupos. Se concluye que la expansión del empleo de la población de mayor edad mantiene el crecimiento económico, generando una demanda de trabajo que puede cubrirse con jóvenes.
Soil drought during the development of cotton ovule destroyed the antioxidant balance of cotton pistil to hinder the ovule formation
Authors: Cheng Mengdie , Wang Zhanhan , Cao Yuting , Zhang Jipeng , Yu Huilian , Wang Shanshan , Zhou Zhiguo , Hu Wei 
Published: February 2024

AbstractReproductive failure in cotton caused by drought has been reported to be closely associated with alterations in pistil fertility; however, the mechanism of the effect of drought on pistil fertility in cotton is less studied. We hypothesized that drought would inhibit the ovule formation to alter pistil potential fertility. To address this hypothesis, we conducted a water deficit induction experiment with a cotton cultivar, Dexiamian 1. Results showed that drought damaged the cytological structure of the developing ovules. This resulted in a lower ovule number, finally leading to lower cottonseed number and boll weight. And the decreased ovule number was closely related to the reactive oxygen species (ROS) accumulation in pistil during ovule development. Further analysis of antioxidant metabolism found that in the enzymatic antioxidant system, drought decreased the activities of superoxide dismutase (SOD) and catalase (CAT), resulting in the accumulation of superoxide anion () and hydrogen peroxide (H2O2). Regarding the non‐enzymatic antioxidant system, the elevated glutathione reductase gene (GhGR) expression under drought promoted the glutathione (GSH) accumulation; however, the decreased dehydroascorbate reductase gene (GhDHAR2) expression under drought inhibited the conversion of GSH to ascorbic acid (AsA). Although the increased monodehydroascorbate reductase gene (GhMDHAR) expression under drought promoted AsA accumulation, drought‐induced reduced ascorbate peroxidase gene (GhAPX) expression inhibited the reduction of H2O2 by AsA, which ultimately led to higher AsA content and H2O2 content. We conclude that drought impedes the ovule formation by disturbing pistil's antioxidant metabolic homeostasis to destruct the cytological structure of the developing ovules.
High‐strength Si–SiC lattices prepared by powder bed fusion, infiltration‐pyrolysis, and reactive silicon infiltration
Authors: Pelanconi Marco , Bottacin Samuele , Bianchi Giovanni , Koch Dietmar , Colombo Paolo , Ortona Alberto 
Published: February 2024

AbstractThis study focuses on the design, additive manufacturing, and characterization of silicon carbide‐based components with complex geometries. These parts were produced using a novel hybrid technique, previously developed: powder bed fusion of polyamide was used to 3D print two different templates with complex architectures. Preceramic polymer infiltrations and pyrolysis with polycarbosilane and furan resin were performed to obtain the ceramic parts. The final densification was achieved with reactive or nonreactive silicon infiltrations according to four different strategies, producing ceramics comprised of crystalline βSiC, reaction‐bonded βSiC, and low residual silicon. The final gyroid samples (∼70 vol% macroporosity) exhibited a maximum compressive strength of 24.7 ± 2.2 MPa, with a skeleton density of 3.173 ± 0.022 g/cm3, and a relative density of 0.935 ± 0.016. These findings underscore the potential of this manufacturing approach and showcase its effectiveness in fabricating intricate ceramic structures for engineering applications as heat exchangers and catalytic supports.
Reliability and validity of the dynamic risk outcome scales—short version for clients with mild intellectual disabilities or borderline intellectual functioning
Authors: Delforterie M. J. , Turhan A. , Driessen M. , Neijmeijer L. , Hesper B. , Didden R. 
Published: February 2024

AbstractIntroductionThis study investigated the reliability and validity of the dynamic risk outcome scales—short version (DROS‐SV). This instrument is developed to monitor treatment progress using dynamic risk factors in clients with mild intellectual disabilities or borderline intellectual functioning and behavioural and/or mental health problems.MethodData were collected from 264 clients who received Flexible Assertive Community Treatment (FACT), a form of intensive outpatient treatment.ResultsA principal component analysis showed that there were six components explaining 73.9% of the variance. Furthermore, the DROS‐SV showed good internal consistency of its subscales and total score (α > 0.78). Correlating the DROS‐SV with the Historical and Clinical subscales of the Historical, Clinical and Future—30 indicated convergent and divergent validity.DiscussionThe DROS‐SV has good psychometric properties for measuring dynamic risk factors in clients with mild intellectual disabilities or borderline intellectual functioning in FACT teams.
Threats to human capital: The effect of health risk on corporate financial policy
Authors: Öztekin Özde 
Published: February 2024

AbstractI examine the relation between threats to human capital and corporate financial policy using morbidity and mortality data related to infectious diseases. I observe a strong association between deteriorating health and declines in leverage, which seems to be influenced by increasing human capital costs offsetting debt benefits. Firms consider reducing debt as a strategic response to perceived employee valuation of human capital insurance, which tends to be affected by a disease‐induced rise in human capital costs. This association appears more pronounced in technology firms, distressed firms, and labor‐intensive firms, and during higher disease‐induced labor uncertainty, with some moderation by labor unions.
Physicochemical properties and flow behavior of natural sweetener and colorant from foam‐mat dried grape powder
Authors: Milani Elnaz , Hashemi Neda , Hashemi Majid 
Published: February 2024

AbstractThe effects of whey protein concentrate, glycerol monostearate, methyl cellulose at a concentration of 1‐3% and gum arabic on the expansion, density and stability of the foam as well as the physicochemical properties of the powder were investigated. The findings identified that the simultaneous addition of foaming and stabilizer agents noticeably affected the quality of the foam. The most stable foam occurred at 3% WPC and 3% MC with density 0.374, expansion 134.4, and stability 95.6. The dried grape powder with a higher proportion of GMS and WPC exhibited the most brightness. The higher level of foaming agents demonstrated lower moisture content, aw, cohesiveness and higher hygroscopicity, flow ability and wettability compared to the non‐foamed one. The study demonstrated the potential use of grape powder as a hygroscopic ingredient in an instant food product, Furthermore, it highlights the importance of selecting appropriate foaming agents to achieve desired properties in the products.Practical applicationsConsidering today's hectic lifestyles and people's increasing awareness of nutrient consumption, consumers prefer ready‐to‐eat and readily available foods that are also health‐oriented. Foam mat drying is an economical alternative to drum, spray, and freeze drying in the production of fruit powders. This process can be used for large‐scale production, because of its suitability for all types of juices, rapid drying at lower temperature, retention of nutritional quality, easy reconstitution, and cost‐effective for producing easily juice powders. Fruit juice powders obtained through this process have high economic potentials over their liquid counterparts such as reduced volume or weight, reduced storage space, simpler handling and transportation, and much longer shelf life. Thus, by conducting this comparative study, valuable insights can be gained into the potential use of foam‐mat dried grape syrup powder as a desirable natural sweetener, colorant, and hygroscopic ingredient for ready meals.
Processing, composition, and technological properties of decorticated, sprouted, and extruded pearl millet (Pennisetum glaucum (L.) R. Br.) flours
Authors: Dias‐Martins Amanda M. , Trombete Felipe M. , Cappato Leandro P. , Chávez Davy W. H. , Santos Monique B. , Carvalho Carlos W. P. 
Published: February 2024

AbstractPearl millet (Pennisetum glaucum (L.) R. Br.) is a gluten‐free cereal with potential use in food security and human nutrition; however, it is still relatively unknown by the food industry and by most consumers. In order to evaluate the impact of processing on the nutritional and technological characteristics of pearl millet flours, three different processing methods (decortication, sprouting, and extrusion) were studied. The effects of processing methods on the particle size distribution, proximate composition, mineral content, bulk density, water absorption index, water solubility index (WSI), and pasting properties (rapid visco analyzer) on the flours were evaluated and compared with whole raw flour. The whole raw flour showed particles size of 355 μm, 62.5% carbohydrate, 12.0% protein, 5.6% lipid, 8.2% dietary fiber, and 1.7% ash. Decorticated flour presented decrease in mineral, dietary fiber, and protein content. The extruded flour presented the highest WSI and the lowest lipid content and paste viscosity, whereas sprouted flour showed low setback, paste viscosity, phytate content, and high protein and dietary fiber content. Decorticated and sprouted flour presented the highest luminosity, whereas extruded flours the smallest L*. The increasing color difference (ΔE*) between raw pearl millet and processed flours was sprouted < decorticated < extruded. The production of millet flour should be encouraged for various food applications, especially in Brazil, which has a large cultivated area of this cereal used only for animal feed and an expanding gluten‐free market.Practical applicationsThe impact of pre‐processing methods on millet grains drives its application in the food industry. All processed flours have the potential to be used as a gluten‐free ingredient for celiacs, people with non‐celiac gluten sensitivity, and for food‐style adepts. The extruded flour has the potential to be used in the development of soups, powder drink, snacks, and breakfast cereal, whereas the sprouted flour can be used in frozen and bakery products. The decorticated flour could be explored as a substitute in different food preparations, such as biscuits, pastas, and breads.