bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital reactivation of territories through geospatial cultural itineraries: the VIDA-HTL web application
Authors: Hidalgo-Sánchez Francisco M. , Merino-del-Río Rebeca , Mascort-Albea Emilio J. , Ruiz-Moreno Ignacio , Linares-GómezDelPulgar Mercedes , Tejedor-Cabrera Antonio 
Published: February 2024

Abstract
The significant imbalances between human settlements and their surrounding environments, stemming from sector-specific policies and urban regional planning tools, constitute a primary factor in the resilience and responsiveness of territories in crisis scenarios. Within this context, the promotion of territorial heritage values emerges as a crucial means for the reactivation of vulnerable areas. Furthermore, the utilisation of technological resources, such as Geographic Information Systems (GIS), has proven to be highly effective in managing cultural landscape areas. This contribution aims to enhance the valorisation of territorial heritage through the geolocation of a system of architectural and archaeological assets of public interest, and by enabling the flexible design of cultural itineraries within the framework of slow tourism. For this purpose, a replicable methodology for the construction of a WebGIS application has been proposed. This methodology has been put into practice in the territorial area of the lower Guadalquivir River in Spain, which encompasses 73 municipalities and one UNESCO World Heritage Site, all interconnected by rural areas. A four-stage plan has been followed for the construction of the VIDA-HTL web application: (1) conceptualisation; (2) development; (3) technical verification; and (4) social viability. The fundamental approach of the web application is based on the comprehensive integration of subsystems related to cultural heritage on one hand, and to tourist and environmental services on the other. Two main functions for the exploration of cultural assets and designing cultural routes have been designed, which complement other capabilities implemented in the web application. As a result of a detailed standardisation process, 981 cultural assets and 43 supplementary data layers have been georeferenced and included in the web application, with customised itineraries available for planning within the study area. Additionally, 49 thematic cultural itineraries are proposed. Finally, the web application is complemented with the development of a collaborative hub, which encourages its use and enhances its capabilities. It is concluded that digital tools, such as that proposed, foster knowledge and valorisation of territorial cultural heritage, while contributing to greater local development. In this way, they function as a counterbalance to the development of metropolises and the global economy, thereby improving levels of regional resilience.
Metabolites from a global regulator engineered strain of Pseudomonas lurida and their inducement of trap formation in Arthrobotrys oligospora
Authors: Sun Yong-Xiang , Zhou Zhi-Fan , Guan Xu-Kang , Deng Jing-Shi , Li Guo-Hong 
Published: February 2024

Abstract
Background
Plant parasitic nematodes (PPNs) cause serious harm to agricultural production. Nematode-trapping fungi (NTF) can produce traps to capture nematodes and are the main resource for controlling nematodes. The number of traps determines the capturing ability of NTF.

Results
Pseudomonas lurida is widely existed in different habitats, which produces active metabolites to induce trap formation of Arthrobotrys oligospora, a famous NTF. To further identify the active substances, metabolic regulation was carried out in the strain by molecular biological methods. A mutant strain P. lurida araC-PoprL with abundant secondary metabolites was constructed, and 19 metabolites (1–19) including a new compound, 1,1-dimethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-3-carboxylic acid (1), were isolated and identified. The activity assay showed that 1-methylhydantoin (9) could effectively induce A. oligospora to produce traps.

Conclusions
P. lurida and the metabolite 1-methylhydantoin effectively induced trap formation in A. oligospora. Both provide sources for the screening of inducing active materials and show potential use in controlling plant parasitic nematodes.

Graphical Abstract
The impact of ECPELLA on haemodynamics and global oxygen delivery: a comprehensive simulation of biventricular failure
Authors: Matsushita Hiroki , Saku Keita , Nishikawa Takuya , Yokota Shohei , Sato Kei , Morita Hidetaka , Yoshida Yuki , Fukumitsu Masafumi , Uemura Kazunori , Kawada Toru , Yamaura Ken 
Published: February 2024

Abstract
Background
ECPELLA, a combination of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) and Impella, a percutaneous left ventricular (LV) assist device, has emerged as a novel therapeutic option in patients with severe cardiogenic shock (CS). Since multiple cardiovascular and pump factors influence the haemodynamic effects of ECPELLA, optimising ECPELLA management remains challenging. In this study, we conducted a comprehensive simulation study of ECPELLA haemodynamics. We also simulated global oxygen delivery (DO2) under ECPELLA in severe CS and acute respiratory failure as a first step to incorporate global DO2 into our developed cardiovascular simulation.

Methods and results
Both the systemic and pulmonary circulations were modelled using a 5-element resistance‒capacitance network. The four ventricles were represented by time-varying elastances with unidirectional valves. In the scenarios of severe LV dysfunction, biventricular dysfunction with normal pulmonary vascular resistance (PVR, 0.8 Wood units), and biventricular dysfunction with high PVR (6.0 Wood units), we compared the changes in haemodynamics, pressure–volume relationship (PV loop), and global DO2 under different VA-ECMO flows and Impella support levels.

Results
In the simulation, ECPELLA improved total systemic flow with a minimising biventricular pressure–volume loop, indicating biventricular unloading in normal PVR conditions. Meanwhile, increased Impella support level in high PVR conditions rendered the LV–PV loop smaller and induced LV suction in ECPELLA support conditions. The general trend of global DO2 was followed by the changes in total systemic flow. The addition of veno-venous ECMO (VV-ECMO) augmented the global DO2 increment under ECPELLA total support conditions.

Conclusions
The optimal ECPELLA support increased total systemic flow and achieved both biventricular unloading. The VV-ECMO effectively improves global DO2 in total ECPELLA support conditions.
Pericardial effusion in oncological patients: current knowledge and principles of management
Authors: Mori S. , Bertamino M. , Guerisoli L. , Stratoti S. , Canale C. , Spallarossa P , Porto I. , Ameri P. 
Published: February 2024

Abstract
Background
This article provides an up-to-date overview of pericardial effusion in oncological practice and a guidance on its management. Furthermore, it addresses the question of when malignancy should be suspected in case of newly diagnosed pericardial effusion.

Main body
Cancer-related pericardial effusion is commonly the result of localization of lung and breast cancer, melanoma, or lymphoma to the pericardium via direct invasion, lymphatic dissemination, or hematogenous spread. Several cancer therapies may also cause pericardial effusion, most often during or shortly after administration. Pericardial effusion following radiation therapy may instead develop after years. Other diseases, such as infections, and, rarely, primary tumors of the pericardium complete the spectrum of the possible etiologies of pericardial effusion in oncological patients.
The diagnosis of cancer-related pericardial effusion is usually incidental, but cancer accounts for approximately one third of all cardiac tamponades. Drainage, which is mainly attained by pericardiocentesis, is needed when cancer or cancer treatment-related pericardial effusion leads to hemodynamic impairment. Placement of a pericardial catheter for 2-5 days is advised after pericardial fluid removal. In contrast, even a large pericardial effusion should be conservatively managed when the patient is stable, although the best frequency and timing of monitoring by echocardiography in this context are yet to be established. Pericardial effusion secondary to immune checkpoint inhibitors typically responds to corticosteroid therapy. Pericardiocentesis may also be considered to confirm the presence of neoplastic cells in the pericardial fluid, but the yield of cytological examination is low.
In case of newly found pericardial effusion in individuals without active cancer and/or recent cancer treatment, a history of malignancy, unremitting or recurrent course, large effusion or presentation with cardiac tamponade, incomplete response to empirical therapy with nonsteroidal anti-inflammatory, and hemorrhagic fluid at pericardiocentesis suggest a neoplastic etiology.
Bulbar-onset amyotrophic lateral sclerosis in a patient with genetically confirmed Huntington’s disease: a case study
Authors: Bozovic Ivo , Gluscevic Sanja , Kezic Ivana , Ivanovic Vukan , Palibrk Aleksa , Peric Stojan , Basta Ivana , Stevic Zorica 
Published: February 2024

Abstract
Background
The rationale for this paper is a description of a patient from Southeast Europe with genetically confirmed Huntington’s disease (HD), coexisting with sporadic, bulbar-onset amyotrophic lateral sclerosis (ALS). To the best of our knowledge, the total number of reported cases with confirmed coexistence of HD and ALS is less than 20. Thus, it is an extremely rare condition speculated to be in a range from 2 to 6 per billion, and data from this part of the World are completely missing.

Case presentation
Here we report a 72-year-old female with a family history of HD who had generalized chorea and hyperreflexia. Using the PCR-based test for the detection of the CAG triplet repeat expansion, the presence of HD was confirmed. After several months, our patient had progressively developed dysarthria and dysphagia, followed by spastic quadriparesis, generalized muscle wasting, spontaneous fasciculations and sialorrhea. The diagnosis of definite ALS was established based on the patient’s neurological status, electromyography findings and current El Escorial criteria.

Conclusions
Our study emphasizes the need for the recognition of the co-occurrence of clinically distinct and rare genetic disorders, such as HD and ALS. New insights from the studies dealing with these rare topics could significantly contribute to the contest of new gene therapy trials.
Return-to-work after interlaminar endoscopic sequestrectomy: case series
Authors: Bozkurt Ismail , Canbolat Cagri , Paksoy Kemal , Senturk Salim , Yaman Onur 
Published: February 2024

Abstract
Background
Considering the epidemiology of single-level lumbar disc herniations (LDH) in the young and active patients, the impact on working capacity is highly relevant. The timing of return-to-work after lumbar surgery through various modalities differs greatly. This may be partly due diverse disparate surgical approaches along with differences in patient and surgeon. The purpose of this paper is to provide evidence for a return-to-work policy after endoscopic sequestrectomy and discuss possible clues to a faster recovery of patients that did not receive a sick-leave report via a case series.

Case presentation
The sample comprises fourteen cases of single-level LDH that underwent endoscopic interlaminar sequestrectomy and did not receive a sick-leave report and were advised to return-to-work whenever they felt fit so. Time until return-to-work, pre- and post-operative leg VAS pain scores and amount of analgesic used post-operatively were retrospectively analyzed. Fourteen patients were operated on using the same technique and on average returned to work after 6.6 ± 1.8 days, used 3.7 ± 2.5 analgesic tablets before returning to work and had a postoperative leg VAS pain score of 1.4 ± 1.2. No patient requested a sick-leave report during the follow-up period of 1 month.

Conclusions
The patients in this case series had a remarkably short period of sick-leave and a low number of analgesic usage. These findings may be due to selection of patients who were operated on specifically for leg pain with the absence of lower back pain suggesting integrity of annulus fibrosus. We can postulate that intraoperative preservation of lamina, facet joint and annulus fibrosus along with reassurance of the surgeon suggesting to return-to-work whenever fell fit so were the key factors in the swifter recovery of the patients.
Assessment of the state of synergies between the structural and functional characteristics of the kidneys and liver during external use of a seaweed product Laminaria algae
Authors: Smirnov I. , Nasibullin B. , Gushcha S. 
Published: February 2024

The authors conducted studies to study the relationship between the functional activity of the kidneys, the detoxification activity of the liver and the structural features of the parenchymatous tissue of these organs under normal conditions and with external use of the laminar algae product “Lamidan”. The work was performed on 164 white outbred Wistar rats weighing 180-200 g. The work was carried out in accordance with current standards for working with laboratory animals. The results of many years of research have shown that normally the indicators of detoxification activity of the liver and functional activity of the kidneys practically do not change, and they correspond to the structural organization of the parenchymatous tissue of these organs, corresponding to the descriptions given in well-known manuals on the activities of these organs. The use of "Lamidan" activates the detoxification function of the liver by 28 % and the functional activity of the kidneys by 28.5 %, i.e. changes are unidirectional and proportionate. In the parenchyma of both organs, changes in the structural organization are recorded, characteristic of an increase in functional activity. Thus, there is a strictly interrelated set of stereotypical changes in the indices of the two organs under study, reflecting between the organs interrelations of functional systems.
Analisis Nilai-nilai Pendidikan Islam Humanis pada Konsep Kurikulum Merdeka: Telaah Pemikiran Abdurrahman Mas’ud
Authors: Nurdin Muh Nur Islam Nurdin , Irfan Jaya  
Published: February 2024

Tujuan penelitian ini ialah mengkaji secara mendalam tentang nilai-nilai Islam humanis dalam konsep kurikulum merdeka. Jenis penelitian yaitu basis kepustakaan menggunakan metode deskriptif-kualitatif dengan paradigma kritis. Penelitian ini terdiri dari dua sumber data utama yakni website Kemendikbudristek tentang Kurikulum Merdekai sebagai sumber primer dan artikel-jurnal, buku-buku, dan sumber lain yang relevan sebagai sumber sekunder. Hasil penelitian menunjukkan Kurikulum Merdeka mengandung nilai-nilai Pendidikan Islam Humanis yaitu nilai pengembangan akal sehat yang terdapat dalam karakteristik pengambangan kompetensi, prinsip memperhatikan hasil kajian umpan balik dan pembelajaran yang berfokus kepada peserta didik, nilai humanisme menuju kemandirian yang terdapat dalam paradigma kurikulum merdeka, nilai semangat keilmuan yang terdapat dalam salah satu aspek dalam mewujudkan tujuan kurikulum merdeka yaitu menumbuhkan kemauan untuk belajar, nilai simbol yang terdapat dalam projek penguatan profil simbol, nilai mengedepankan fungsi daripada simbol yang terdapat dalam aspek prinsip kurikulum yaitu prinsip berfokus pada kompetensi dan prinsip bergotong royong, dan nilai Keseimbangan reward dan punishment yang terbaca dari pengurangan konten dan pembelajaran yang berfokus kepada peserta didik. Diharapkan, temuan ini memberikan kontribusi signifikan dalam memahami nilai-nilai yang terdapat dalam kurikulum merdeka.
Computational study of ADME-Tox prediction of selected phytochemicals from Punica granatum peels
Authors: Batool Aneeqa , Parveen Shagufta , Shafiq Nusrat , Rashid Maryam , Salamatullah Ahmad Mohammad , Ibenmoussa Samir , Bourhia Mohammed 
Published: February 2024

Abstract
Pomegranate (Punica granatum) is one of the oldest well-known edible fruits, which has originated in Central Asia but now it has a widespread geographical distribution throughout the world. Phytochemicals are isolated from the pomegranate peels that show different nutritional and pharmaceutical properties. Absorption, distribution, metabolism, excretion, and toxicity (ADME-Tox) were performed to check the adsorption, distribution, metabolism, excretion, and toxicity of compounds. Previous studies mainly focused on the physico-chemical properties but other parameters are also important for the ADMET study. Six active phytochemicals B9, B29, B30, B45, B55, and B70 show good ADMET properties and can be used for drug discovery in the future.
Predicting Time to Graduation of Open University Students: An Educational Data Mining Study
Authors: Santoso Agus , Retnawati Heri , Kartianom  , Apino Ezi , Rafi Ibnu , Rosyada Munaya Nikma 
Published: February 2024

Abstract
The world’s move to a global economy has an impact on the high rate of student academic failure. Higher education, as the affected party, is considered crucial in reducing student academic failure. This study aims to construct a prediction (predictive model) that can forecast students’ time to graduation in developing countries such as Indonesia, as well as the essential factors (attributes) that can explain it. This research used a data mining method. The data set used in this study is from an Indonesian university and contains demographic and academic records of 132,734 students. Demographic data (age, gender, marital status, employment, region, and minimum wage) and academic (i.e., grade point average (GPA)) were utilized as predictors of students’ time to graduation. The findings of this study show that (1) the prediction model using the random forest and neural networks algorithms has the highest classification accuracy (CA), and area under the curve (AUC) value in predicting students’ time to graduation (CA: 76% and AUC: 79%) compared to other models such as logistic regression, Naïve Bayes, and k-nearest neighbor; and (2) the most critical variable in predicting students’ time to graduation along with six other important variables is the student’s GPA.
Isolation, screening and optimization of alkaliphilic cellulolytic fungi for production of cellulase
Authors: Zainuddin Nor’Izzah , Makhtar Muaz Mohd Zaini , Gunny Ahmad Anas Nagoor , Gopinath Subash Chandra Bose , Ahmad Abdul Aziz , Pusphanathan Kavita , Siddiqui Masoom Raza , Alam Mahboob , Rafatullah Mohd 
Published: February 2024

Abstract
This study concerns with the production and partial characterization of alkaline cellulase from alkaliphilic cellulolytic (AC) fungi isolated fromsoil in Perlis, Malaysia. The best fungi strain was selected on the basis of producing the highest cellulase at high pH conditions. Cellulase from the selected fungi strain was further characterized under saccharification but varies in operating parameters. Finally, the kinetic model describing the growth of the AC fungi strain was studied by employing the logistic model. Among the tested fungi strains, Basidiomycetes strain (BK1) showed high potentiality for the production of maximum alkaline cellulase production at pH 9 after 72 h of incubation at 30°C containing 6 g·L−1 carboxyl methyl cellulose. The saccharification process showed that the enzyme favour high alkaline condition and proves thermotolerant properties, while 15% (v/v) enzyme loading and 1% substrate concentration recorded the highest glucose production at about 1.2–1.3 mg·mL−1. The novelty of the study is to identify and optimize a unique indigenous fungi that emit alkaliphilic cellulase as alternative usage in biotechnology industries due to its capacity to adapt to the extreme conditions of specific industrial processes. There are revolutionary options for use in biotechnological businesses that involve high pH and therefore have substantial biotechnological promise.
Social media addiction and depression and their predictors among university students
Authors: Shanshal Sadeel A. , Al-Qazaz Harith Kh. , Saadallah Dalal A. , Mohammed Shaimaa Y. , Saber Qater Al-nada Y. , Ali Modur M. , Mahmmod Wasan N. 
Published: February 2024

Abstract

Objectives
Social media facilitate the interaction between individuals without regard to the distances between the users. Everybody who has access to internet can suffer from social media addiction. During COVID-19 pandemic there was an increase in social media usage among all population types and especially the university students, which would negatively affect their mental health. Therefore, this study aims at assessing social media addiction and depression among pharmacy students by using questionnaires specifically designed for this purpose.

Methods
A cross-sectional study with convenience sampling was conducted from the start of November to the end of December 2021 among undergraduate pharmacy students in Mosul city, Iraq. An online questionnaire was adopted; it consisted of three parts, the first was for collecting socio-demographic and social media usage information, Social Media Addiction Questionnaire (SMAQ) was used in the second part to assess social media addiction of the participants, and the third part was comprised of the Patient Health Questionnaire (PHQ-9) to assess depression among students.

Results
Six hundred-three students completed the questionnaire and constituted the final study sample. Instagram was the most used social media program among the students. About 38 % of the students were at risk of becoming addicted on social media, with only 8.4 % of them being minimally or not depressed. Additionally, positive significant correlation was observed between social media addiction and depression. Using social media for more than 4 h and poor academic performance were found to be predictors for social media addiction and depression.

Conclusions
Addiction to social media and depression are prevalent among pharmacy students in Iraq and the two are related to each other.
Integrative pathway analysis with gene expression, miRNA, methylation and copy number variation for breast cancer subtypes
Authors: Linder Henry , Zhang Yuping , Wang Yunqi , Ouyang Zhengqing 
Published: February 2024

Abstract
Developments in biotechnologies enable multi-platform data collection for functional genomic units apart from the gene. Profiling of non-coding microRNAs (miRNAs) is a valuable tool for understanding the molecular profile of the cell, both for canonical functions and malignant behavior due to complex diseases. We propose a graphical mixed-effects statistical model incorporating miRNA-gene target relationships. We implement an integrative pathway analysis that leverages measurements of miRNA activity for joint analysis with multimodal observations of gene activity including gene expression, methylation, and copy number variation. We apply our analysis to a breast cancer dataset, and consider differential activity in signaling pathways across breast tumor subtypes. We offer discussion of specific signaling pathways and the effect of miRNA integration, as well as publish an interactive data visualization to give public access to the results of our analysis.