bluuebunny/crossref_metadata_2025_split huggingface dataset:
Purpose reflection benefits minoritized students’ motivation and well-being in STEM
Authors: Diekman Amanda B. , Joshi Mansi P. , White Andrew D. , Tran Quang-Anh Ngo , Seth Jayshree 
Published: January 2024

AbstractStudents from groups historically excluded from STEM face heightened challenges to thriving and advancing in STEM. Prompting students to reflect on these challenges in light of their purpose can yield benefits by helping students see how their STEM work connects to fundamental motives. We conducted a randomized, controlled trial to test potential benefits of reflecting on purpose—their “why” for pursuing their degrees. This multimethod study included 466 STEM students (232 women; 237 Black/Latinx/Native students). Participants wrote about their challenges in STEM, with half randomly assigned to consider these in light of their purpose. Purpose reflection fostered benefits to beliefs and attitudes about the major, authentic belonging, and stress appraisals. Effects were robust across race and gender identities or larger for minoritized students. Structural and cultural shifts to recognize students’ purpose in STEM can provide a clearer pathway for students to advance.
Aryl-quinoline-4-carbonyl hydrazone bearing different 2-methoxyphenoxyacetamides as potent α-glucosidase inhibitors; molecular dynamics, kinetic and structure–activity relationship studies
Authors: Hamedifar Haleh , Mirfattahi Mahroo , Khalili Ghomi Minoo , Azizian Homa , Iraji Aida , Noori Milad , Moazzam Ali , Dastyafteh Navid , Nokhbehzaim Ali , Mehrpour Katayoun , Javanshir Shahrzad , Mojtabavi Somayeh , Faramarzi Mohammad Ali , Larijani Bagher , Hajimiri Mir Hamed , Mahdavi Mohammad 
Published: January 2024

AbstractRegarding the important role of α-glucosidase enzyme in the management of type 2 diabetes mellitus, the current study was established to design and synthesize aryl-quinoline-4-carbonyl hydrazone bearing different 2-methoxyphenoxyacetamide (11a–o) and the structure of all derivatives was confirmed through various techniques including IR, 1H-NMR, 13C-NMR and elemental analysis. Next, the α-glucosidase inhibitory potentials of all derivatives were evaluated, and all compounds displayed potent inhibition with IC50 values in the range of 26.0 ± 0.8–459.8 ± 1.5 µM as compared to acarbose used as control, except 11f and 11l. Additionally, in silico-induced fit docking and molecular dynamics studies were performed to further investigate the interaction, orientation, and conformation of the newly synthesized compounds over the active site of α-glucosidase.
Identification of desalination and wind power plants sites using m-polar fuzzy Aczel–Alsina aggregation information
Authors: Rahman Zia Ur , Ali Ghous , Asif Muhammad , Chen Yufeng , Abidin Muhammad Zain Ul 
Published: January 2024

AbstractReal-world decision-making problems often include multi-polar uncertainties dependent on multi-dimensional attributes. Them-polar fuzzy (mF) sets can efficiently handle such multi-faceted complications with T-norm based weighted aggregation techniques. The Aczel–Alsina T-norms offer comparatively flexible and accurate aggregation than the other well-known T-norm families. Consequently, this work introduced novelmF Aczel–Alsina aggregation operators (AOs), including weighted averaging (mFAAWA,mFAAOWA,mFAAHWA) and weighted geometric (mFAAWG,mFAAOWG,mFAAHWG) AOs. The fundamental properties, including boundedness, idempotency, monotonicity, and commutativity are investigated. Based on the proposed AOs, a decision-making algorithm is developed and implemented to solve two detailed multi-polar site selection problems (for desalination plant and for wind-power plant). Finally, a comparison withmF Dombi andmF Yager AOs reveals that different T-norm based AOs may yeild different solutions for the same problem.
Multi-wavelength interference phase imaging for automatic breast cancer detection and delineation using diffuse reflection imaging
Authors: Mahmoud Alaaeldin , El-Sharkawy Yasser H. 
Published: January 2024

AbstractMillions of women globally are impacted by the major health problem of breast cancer (BC). Early detection of BC is critical for successful treatment and improved survival rates. In this study, we provide a progressive approach for BC detection using multi-wavelength interference (MWI) phase imaging based on diffuse reflection hyperspectral (HS) imaging. The proposed findings are based on the measurement of the interference pattern between the blue (446.6 nm) and red (632 nm) wavelengths. We consider implementing a comprehensive image processing and categorization method based on the use of Fast Fourier (FF) transform analysis pertaining to a change in the refractive index between tumor and normal tissue. We observed that cancer growth affects tissue organization dramatically, as seen by persistently increased refractive index variance in tumors compared normal areas. Both malignant and normal tissue had different depth data collected from it that was analyzed. To enhance the categorization of ex-vivo BC tissue, we developed and validated a training classifier algorithm specifically designed for categorizing HS cube data. Following the application of signal normalization with the FF transform algorithm, our methodology achieved a high level of performance with a specificity (Spec) of 94% and a sensitivity (Sen) of 90.9% for the 632 nm acquired image categorization, based on preliminary findings from breast specimens under investigation. Notably, we successfully leveraged unstained tissue samples to create 3D phase-resolved images that effectively highlight the distinctions in diffuse reflectance features between cancerous and healthy tissue. Preliminary data revealed that our imaging method might be able to assist specialists in safely excising malignant areas and assessing the tumor bed following resection automatically at different depths. This preliminary investigation might result in an effective "in-vivo" disease description utilizing optical technology using a typical RGB camera with wavelength-specific operation with our quantitative phase MWI imaging methodology.
Automated quantity take-off in a Norwegian road project
Authors: Fürstenberg David , Hjelseth Eilif , Klakegg Ole Jonny , Lohne Jardar , Lædre Ola 
Published: January 2024

AbstractAutomated quantity take-off from digital models in road projects has many benefits. In real project settings, however, it seems rarely to take place. This paper investigates automated quantity take-off in a real-life road project and the experiences from this automation. A literature and a document study were performed. 48 domain models serialized in IFC 2 × 3 were then analyzed before 10 project members were interviewed. The quantity take-off was automated to harvest classified quantities to a specification of work. The automated quantity take-off was reproducible at revisions for 40% of the cost items. However, the transferability of the procedures to other use cases than the specification of work is questionable because of the applied cost breakdown structure. The findings suggest three practical improvements for automated quantity take-off in road projects. The three include (1) using unambiguous classes assembled in an ontology, (2) avoiding hard coding of cost breakdown structures in authoring tools, and (3) implementing the Level of Information Need (LOIN) to improve reusability across project phases and use cases. The quantity take-off and experiences are assessed from the designer's perspective. The client’s and contractor’s perspectives were out of this paper’s scope.
Liberal surgical laparoscopy reduction for acute intussusception: experience from a tertiary pediatric institute
Authors: Yang Jian , Wang Guoyong , Gao Jia , Zhong Xiaotong , Gao Kai , Liu Qianyang , Nan Guoxin , Yan Chengwei , Chen Gongli , Lu Peng , Guo Chunbao 
Published: January 2024

AbstractThe optimal treatment for acute intussusception has not yet been defined. In this study, we explored whether employing a liberal laparoscopic intervention for intussusception could lead to favorable outcomes. We performed a historical control analysis to evaluate the outcomes associated with this liberal surgical management protocol. This liberal surgical management protocol were revised to incorporate a new protocol centered around the laparoscopic approach. In some cases of acute intussusception, liberal laparoscopic exploration and intervention were undertaken without initial hydrostatic or pneumatic reduction. During the study interval, a retrospective review was conducted on a total of 3086 patients. These were categorized into two groups: 1338 cases before May 2019 (pre-protocol group) and 1748 cases after May 2019 (post-protocol group). Surgical intervention rates in the pre-protoco and post-protocol period were 10.2% and 27.4% respectively (odds ratio [OR] = 0.30 [95% CI 0.25–0.37]; p < 0.001). No significant differences were observed in baseline clinical characteristics or demographic features between the two groups. The duration from admission to operation was longer for the pre-protocol group (p = 0.008) than for the post-protocol group. The post-protocol group demonstrated decreases in both intestinal resection (OR = 1.50 [95% CI 0.96–2.35]; p = 0.048) and total recurrent events (OR = 1.27 [95% CI 1.04–1.55]; p = 0.012) compared to the pre-protocol group. Liberal laparoscopic intervention for intussusception may effectively reduce the risk of intestinal resection and total recurrent events, thereby exhibiting promising outcomes for patients with intussusception.
Maintenance of crack with infilling polymer modified mortar for shear deficient of reinforced concrete beam
Authors: Waqas Rana Muhammad , Elahi Ayub , Kırgız Mehmet Serkan , Nagaprasad N. , Ramaswamy Krishnaraj 
Published: January 2024

AbstractBeing a developing country, Pakistan needs sustainable and cost-effective strengthening/ retrofitting solution to be adopted/ practiced in the construction industry. The research reported in this paper was aimed to study the effectiveness of PMM, an indigenous product, for repairing reinforced concrete beams, resulting more effective and cost benefiting repair and strengthening for restoration of pre-cracked RC structures. This article presents the research results of experimental investigation conducted for repairing of cracks in shear deficient reinforced concrete (RC) beams with locally available novel material polymer modified mortar (PMM). A total of 6 beams; divided in three groups i.e. short beams, medium beams and deep beams with varying depths and same mix design were tested to four point loading under monotonic loading conditions until failure loads. Afterwards, these beams were repaired with PMM and cured with water for 72 h for retesting until failure. Load at first crack and at failure, crack pattern and deflections were recorded for all specimens during testing. Results from the experimental investigation indicate that load carrying capacity of the repaired beams was significantly restored in comparison to the control specimens. However, repaired specimens of medium group showed more improvement in load carrying capacity as compared with those of repaired specimens of short and deep group. The specimens of medium group restored up to 90% of their original load carrying capacity. The ductility is improved significantly for all shear critical repaired RC beams up to opening of cracks. Sudden brittle failure was observed after opening of repaired cracks. The contribution of PMM to load carrying capacity was found more significant for medium beams as compared to short and deep beams. The results of this study indicated that application of polymer modified mortar is effective technique for repairing of cracks in shear deficient RC beams.
Characterization, antibacterial, and cytotoxic activities of silver nanoparticles using the whole biofilm layer as a macromolecule in biosynthesis
Authors: Yakoup Aghapy Yermans , Kamel Azza G. , Elbermawy Yasmin , Abdelsattar Abdallah S. , El-Shibiny Ayman 
Published: January 2024

AbstractRecently, multi-drug resistant (MDR) bacteria are responsible for a large number of infectious diseases that can be life-threatening. Globally, new approaches are targeted to solve this essential issue. This study aims to discover novel antibiotic alternatives by using the whole components of the biofilm layer as a macromolecule to synthesize silver nanoparticles (AgNPs) as a promising agent against MDR. In particular, the biosynthesized biofilm-AgNPs were characterized using UV-Vis spectroscopy, electron microscopes, Energy Dispersive X-ray (EDX), zeta sizer and potential while their effect on bacterial strains and normal cell lines was identified. Accordingly, biofilm-AgNPs have a lavender-colored solution, spherical shape, with a size range of 20–60 nm. Notably, they have inhibitory effects when used on various bacterial strains with concentrations ranging between 12.5 and 25 µg/mL. In addition, they have an effective synergistic effect when combined with phage ZCSE9 to inhibit and killSalmonella entericawith a concentration of 3.1 µg/mL. In conclusion, this work presents a novel biosynthesis preparation of AgNPs using biofilm for antibacterial purposes to reduce the possible toxicity by reducing the MICs using phage ZCSE9.
A degradation feature extraction technique based on static divided symbol sequence entropy
Authors: Gu Chunxia , Bi Juan , Wang Bing 
Published: January 2024

AbstractDue to the doping of considerable noise and impact components in vibration signals of quay crane gearboxes, some traditional methods have difficulty uncovering degradation patterns. To accurately extract degradation features from vibration monitoring signals, a degradation feature extraction technique based on static divided symbol sequence entropy is proposed. Based on the basic scale entropy technique, considering the uniformity of the symbolization standard, the technique takes the root mean square of the health condition signal as the basis and incorporates the scale coefficient to establish a uniform basic scale. Simultaneously, the symbol set is expanded to enhance the information content and the ability of the approach to characterize the complexity levels of signals in large-value regions. Therefore, the proposed static divided symbol sequence entropy technique can accurately and flexibly characterize performance degradations. The logistic chaotic sequence and the lifetime signal of hoisting mechanism gearbox are separately used for analysis. It shows that the proposed technique can characterize the complexity of the nonlinear time series and sensitively describe the performance degradation exhibited by hoisting mechanism gearbox. This technique is computationally fast, and it can be implemented as a foundation for developing new methods for evaluating the health conditions of quay crane gearboxes.
Effect of the peripartum depressive symptoms on the Internet use disorder of their offspring in late childhood: retrospective longitudinal study
Authors: Kim Jinhyun , Hurh Kyungduk , Kim Hyunkyu , Park Eun-Cheol , Ha Min Jin 
Published: January 2024

AbstractInternet use disorder (IUD) is an emerging social and mental health concern. This study aimed to analyze the relative risk of IUD in late childhood among children whose mothers experienced peripartum depressive symptoms. This study included 762 participants (397 boys and 365 girls) and was conducted in 2017 (aged 9) and 2019 (aged 11). We analyzed the adjusted relative risk of being at high risk for IUD based on whether the mother experienced depressive symptoms during pregnancy or one month after delivery. We also considered the persistence of depressed mood for 4 months after delivery and the severity of peripartum depressive symptoms. From 2017, 20.7% of boys and 14.0% of girls were at high risk of developing IUD. Compared to the non-peripartum depressive group, girls whose mothers experienced peripartum depressive symptoms and those that persisted for 4 months were 1.084 and 1.124 times more likely to be at high risk of IUD (95% confidence interval = 1.005–1.170 and 1.013–1.248), respectively. There were no statistically significant differences among boys. Peripartum depressed mood could be one of risk factors of IUD. IUD needs to be monitored in children whose mothers experienced peripartum depressive symptoms.
Examining factors contributing to the socioeconomic inequalities in handgrip strength among older adults in India: a decomposition analysis
Authors: Pai Manacy , Muhammad T. 
Published: January 2024

AbstractThe purpose of this study was to examine (a) the socioeconomic status (SES)-related inequalities associated with handgrip strength (HGS); and (b) the extent to which several demographic, health, and behavioral factors contributed to such SES disparities in HGS among older adults in India. Data were drawn from the 2017–2018 wave 1 of the Longitudinal Ageing Study of India (LASI). The study sample included 27,707 older adults (13,199 men and 14,508 women) aged 60 years and older. HGS was assessed using a handheld Smedley's Hand Dynamometer with a cut-off of 19.5 kg for men and 12.5 kg for women. Bivariate analysis showed the weighted percentage distribution of weak HGS across respondent characteristics. Multivariate logistic regression assessed factors linked to weak HGS. The concentration curve and index (CCI) was used to determine the inequalities in the prevalence of weak HGS by wealth index scores. Wagstaff's decomposition approach was used to test the contribution of each explanatory variable to weak HGS. Around 9% of older adults in this study reported a weak HGS. It was significantly higher among those aged 80 or older (19.21%) and males (15.55%). Weak HGS was concentrated among older adults from poor SES (CCI: 0.05, p < 0.001). A higher percentage of wealth-based inequality in weak HGS was explained by being underweight (38.83%), belonging to the richest wealth quintile (27.95%), and having a higher subjective social status (32.20%). Moreover, about 23.29% of the inequality in weak HGS was explained by Western region and 22.54% by female gender. Additionally, having a secondary level of education explained a higher percentage (22.09%) of inequality, followed by current working status (− 20.68%). Rural residence (13.08%), limitations in instrumental activities of daily living (IADL) (12.21%), and engagement in yoga-related activities (11.55%) explained a higher percentage of wealth-based inequalities. The findings provide evidence of significant SES-related inequalities in HGS and the contribution of various demographic, health, and behavioral factors to such inequality. As such, public health policies and programs focusing on reducing the burden of disability must consider the contribution of social and economic equity to the preservation of muscle strength among older adults.
Magnitude of effect and sample size justification in trials supporting anti-cancer drug approval by the US Food and Drug Administration
Authors: Nadler Michelle B. , Wilson Brooke E. , Desnoyers Alexandra , Valiente Consolacion Molto , Saleh Ramy R. , Amir Eitan 
Published: January 2024

AbstractApproval of drugs is based on randomized trials observing statistically significant superiority of an experimental agent over a standard. Statistical significance results from a combination of effect size and sampling, with larger effect size more likely to translate to population effectiveness. We assess sample size justification in trials supporting cancer drug approvals. We identified US FDA anti-cancer drug approvals for solid tumors from 2015 to 2019. We extracted data on study characteristics, statistical plan, accrual, and outcomes. Observed power (Pobs) was calculated based on completed study characteristics and observed hazard ratio (HRobs). Studies were considered over-sampled if Pobs > expected with HRobs similar or worse than expected or if Pobs was similar to expected with HRobs worse than expected. We explored associations with over-sampling using logistic regression. Of 75 drug approvals (reporting 94 endpoints), 21% (20/94) were over-sampled. Over-sampling was associated with immunotherapy (OR: 5.5; p = 0.04) and associated quantitatively but not statistically with targeted therapy (OR: 3.0), open-label trials (OR: 2.5), and melanoma (OR: 4.6) and lung cancer (OR: 2.17) relative to breast cancer. Most cancer drug approvals are supported by trials with justified sample sizes. Approximately 1 in 5 endpoints are over-sampled; benefit observed may not translate to clinically meaningful real-world outcomes.
Quasi-instantaneous materials processing technology via high-intensity electrical nano pulsing
Authors: Olevsky Eugene A. , Jiang Runjian , Xu Wenwu , Maximenko Andrii , Grippi Thomas , Torresani Elisa 
Published: January 2024

AbstractDespite many efforts, the outcomes obtained with field-assisted processing of materials still rely on long-term coupling with other electroless processes. This conceals the efficacy and the intrinsic contributions of electric current. A new device utilizing electrical nano pulsing (ENP) has been designed and constructed to bring quasi-instantaneous modifications to the micro- and nano-structure in materials. Featuring ultra-high intensity (~ 1011 A/m2) and ultra-short duration (< 1 μs), the ENP technology activates non-equilibrium structural evolutions at nanometer spatial scale and nanosecond temporal scale. Several examples are provided to demonstrate its utility far outpacing any conventional materials processing technology. The ENP technology gives a practical tool for exploring the intrinsic mechanism of electric-field effects and a pathway towards the rapid industrial manufacturing of materials with unique properties.
Spatial structure and network characteristics of the coupling coordination innovation ecosystems in the Guangdong–Hong Kong–Macao Greater Bay area
Authors: Yang Zhichen , Li Xiangtao , Wang Fangfang , Chen Rongjian , Ma Renwen 
Published: January 2024

AbstractIn recent times, a new wave of scientific and technological advancements has significantly reshaped the global economic structure. This shift has redefined the role of regional innovation, particularly in its contribution to developing the Guangdong–Hong Kong–Macao Greater Bay area (GBA) into a renowned center for science, technology, and innovation. This study constructs a comprehensive evaluation system for the Regional Innovation Ecosystem (RIE). By applying the coupling coordination degree model and social network analysis, we have extensively analyzed the spatial structure and network attributes of the coupled and coordinated innovation ecosystem in the GBA from 2010 to 2019. Our findings reveal several key developments: (1) There has been a noticeable rightward shift in the kernel density curve, indicating an ongoing optimization of the overall coupling coordination level. Notably, the center of gravity for coupling coordination has progressively moved southeast. This shift has led to a reduction in the elliptical area each year, while the trend surface consistently shows a convex orientation toward the center. The most significant development is observed along the ‘Guangdong–Shenzhen–Hong Kong–Macao Science and Technology Innovation Corridor’, where the level of coupling coordination has become increasingly pronounced. (2) The spatial linkages within the GBA have been strengthening. There are significant spatial transaction costs in the regional innovation ecological network. In the context of the 2019 US-China trade war, the cities of Jiangmen and Zhaoqing experienced a notable decrease in connectivity with other cities, raising concerns about their potential marginalization. (3) Guangzhou, Shenzhen, and Hong Kong have emerged as core nodes within the network. The network exhibits a distinctive “core–edge” spatial structure, characterized by both robustness and vulnerability in various aspects.