bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enterprise resource planning: a review and a STOPE view
Authors: Bakry Ali Haj , Bakry Saad Haj 
Published: August 2005

AbstractEnterprise resource planning (ERP) systems are becoming of increasing importance as integrated parts of business networks. They support ‘e‐business implementation’ for better enterprise performance, ‘integrate activities’ for higher enterprise efficiency, and enjoy a ‘modular architecture’, for future extensions and further benefits. The aim of this review is to introduce ERP systems and explore their current state and future potentials. Using recent literature, the review provides a comprehensive understanding of ERP systems, including illustrating their main components and clarifying their basic and extended features. In addition, the review highlights the main producers of ERP systems, together with their partners and customers. Based on previous investigations, the review also addresses ERP selection criteria and critical implementation factors. Finally, recent views of ERP systems and their future development, including their enhanced intelligence, expansion, and management, are given. The views also include a STOPE view (strategy, technology, organization–enterprise, people, environment), which illustrates the integration of ERP systems with the overall enterprise network. Copyright © 2005 John Wiley & Sons, Ltd.
The trade‐off between cardiovascular and gastrointestinal effects of rofecoxib
Authors: Florentinus Stefan R. , Heerdink Eibert R. , Boer Antonius de , van Dijk Liset , Leufkens Hubert G.M. 
Published: August 2005

AbstractThe original article to which this Erratum refers was published in Pharmacoepidemiology and Drug Safety, 14 (7) 2005, 437–441.No Abstract.
Peroxisomal proteomics, a new tool for risk assessment of peroxisome proliferating pollutants in the marine environment
Authors: Mi Jia , Orbea Amaia , Syme Neil , Ahmed Meftun , Cajaraville Miren P. , Cristóbal Susana 
Published: August 2005

AbstractIn an attempt to improve the detection of peroxisome proliferation as a biomarker in environmental pollution assessment, we have applied a novel approach based on peroxisomal proteomics. Peroxisomal proteins from digestive glands of mussels Mytilus galloprovincialis were analyzed using 2‐DE and MS. We have generated a reference 2‐DE map from samples obtained in a well‐studied reference area and compared this with peroxisomal proteomes from other sequenced genomes. In addition, by comparing 2‐DE maps from control samples with samples obtained in a polluted area, we have characterized the peroxisome proliferation expression pattern associated with exposure to a polluted environment. Over 100 spots were reproducibly resolved per 2‐DE map; 55 differentially expressed spots were quantitatively detected and analyzed, and 14 of these showed an increase in protein expression of more than fourfold. Epoxide hydrolase, peroxisomal antioxidant enzyme, and sarcosine oxidase (SOX) have been identified by ESI MS/MS, and acyl‐CoA oxidase, multifunctional protein, and Cu,Zn‐superoxide dismutase were immunolocalized by Western blotting. Our results indicate that a peroxisomal protein pattern associated to marine pollutant exposure can be generated, and this approach may have a greater potential as biomarker than traditional, single‐protein markers.
Expression of fragile X mental retardation‐1 gene with nuclear export signal mutation changes the expression profiling of mouse cerebella immortal neuronal cell
Authors: Hu LiPing , Chen YuTing , Evers Stefan , Shen Yan 
Published: August 2005

AbstractFragile X syndrome (FXS) is the most frequent cause of inherited mental retardation and is largely caused by a loss of expression of fragile X mental retardation protein (FMRP), encoded by fragile X retardation gene‐1 (Fmr1). FMRP is a multifunction protein, with intrinsic RNA‐binding properties, which is a component of ribonucleoprotein complex associated with polyribosomes. The properties of FMRP indicate that it might participate in post‐transcriptional processes in the regulation of some mRNA species, including localization, stability and translational control. However, the function of FMRP related to the pathologenesis in FXS is largely unknown. Many efforts were undertaken to identify the putative specific RNA targets as well as the FMRP‐related proteins and to identify the effect of FMRP absence on the corresponding proteins. Here we present our efforts using proteomics approach to explore the differential expression profiling of mouse cerebella immortal cell, in which we changed the expression of FMRP by expressing Fmr1 gene with nuclear export signal (NES) mutation. This mutation makes FMRP unable to shuttle from nucleus to cytoplasm and leads to nuclear instead of cytoplasmic location as usual, which was hypothesized to affect the pathways of groups of RNAs or proteins related with FMRP. In present study, 56 proteins were found to be differentially expressed in transfected R2 neuronal cells, including 16 decreased expressions and 40 increased expressions. The differentially expressed proteins play roles in diverse physiological processes, such as neuronal plasticity, spermatogenesis and craniofacial and limb development etc. In addition, the expressions of three mRNA identified as FMRP targets in fragile X cell were tested in present model cells. All these results provide new insights to the role of FMRP in the disease.
Immunodepletion of albumin for two‐dimensional gel detection of new mouse acute‐phase protein and other plasma proteins
Authors: Duan Xunbao , Yarmush David , Berthiaume François , Jayaraman Arul , Yarmush Martin L. 
Published: August 2005

AbstractImmunodepletion of albumin to improve the 2‐D gel resolution of human plasma proteins has recently been described. With the importance of mouse models in many studies in which serum or plasma is often analyzed, we have adopted this approach to immunoprecipitate mouse albumin and evaluated its effectiveness for 2‐D separation of mouse plasma proteins. Purified polyclonal antibodies against mouse albumin were effective depleting intact albumin as well as its numerous fragments from mouse plasma samples. Removal of albumin resulted in better resolution of mouse plasma proteins. Three proteins, α2‐macroglobulin, coagulation factor XII, and hemopexin, that were previously either undetectable or poorly resolved, were identified from albumin‐depleted 2‐D gels by peptide mass fingerprinting. Albumin depletion also led to partial loss of several other proteins such as clusterin and gelsolin. This loss can be attributed to the interaction with albumin itself because the specificity of the antibody was demonstrated by Western blot. When applying this method to the 2‐D separation of plasma from inflamed mouse induced by cutaneous burn injury with superimposed Pseudomonas aeruginosa infection, the upregulation of inter α‐trypsin inhibitor heavy chain 4 (ITIH4) and hemopexin was unambiguously detected along with other mouse acute‐phase proteins (APP), including haptoglobin and serum amyloid A. Based on the significant increase of ITIH4, we propose that this protein is a new member of mouse APP that are upregulated during the inflammatory response.
Simple and effective technical procedures for the packing and application of nanospray PicoFrit HPLC columns for proteomic analyses
Authors: Howells Laurence C. , Whelan Adam O. , Woodward Martin J. , Coldham Nick G. 
Published: August 2005

AbstractA simple procedure was developed for packing PicoFrit HPLC columns with chromatographic stationary phase using a reservoir fabricated from standard laboratory HPLC fittings. Packed columns were mounted onto a stainless steel ultra‐low volume precolumn filter assembly containing a 0.5‐µm pore size steel frit. This format provided a conduit for the application of the nanospray voltage and protected the column from obstruction by sample material. The system was characterised and operational performance assessed by analysis of a range of peptide standards (n = 9).
Self‐made frits for nanoscale columns in proteomics
Authors: Maiolica Alessio , Borsotti Dario , Rappsilber Juri 
Published: August 2005

AbstractWe report here the production of self‐made frits for nano‐columns. The frits introduce a minor dead volume and can be placed in capillaries with a wide range of diameters (20–250 µm tested) in an extremely simple and low‐cost procedure. The obtained columns appear to be comparable to “no‐frit” columns with near‐ideal chromatographic characteristics. We expect that this frit will be useful for the spotting of gradients onto MALDI plates but also where special ESI set‐ups do not allow for “no‐frit” solutions.
Protein kinase C‐mediated phosphorylation of orphan nuclear receptor TR2: Effects on receptor stability and activity
Authors: Khan Shaukat Ali , Park Sung Wook , Huq Mostaqul , Wei Li‐Na 
Published: August 2005

AbstractIn vivo metabolic labeling showed that orphan nuclear receptor TR2 could be phosphorylated. Systematic studies were conducted using specific kinases/phosphatase inhibitors to determine the enzymes responsible for TR2 phosphorylation and the effects of TR2 phosphorylation on its protein stability and activation of its target gene. The data showed that protein kinase C (PKC)‐mediated phosphorylation enhanced the activating ability of TR2 on target gene RARβ as well as its stability through protection from proteosome‐mediated degradation. Several PKC‐mediated potential serine/threonine phosphorylation sites on TR2 protein were predicted from the computer analysis using NetPhos software (http://us.expasy.org) and were commensurate by in vitro phosphorylation of purified TR2 protein using PKC enzyme. Two phosphorylation sites at Ser‐461 and Ser‐568 were identified by LC‐ESI‐MS/MS. Point mutations at Ser‐568 or Ser‐461 were prepared and evaluated for their biological activity. Ser‐568, but not Ser‐461, mutation significantly reduced PKC‐mediated TR2 protein stability and its transcriptional activity.
Double‐layered composite nanofibers and their mechanical performance
Authors: Huang Zheng‐Ming , Zhang Yanzhong , Ramakrishna S. 
Published: August 2005

AbstractContinuous polymer nanofibers are available through electrospinning, but most have the same structure in their cross section. This article focuses on the fabrication and the structural and mechanical characterization of pencil‐like double‐layered composite nanofibers coaxially electrospun from solutions of two different biodegradable materials, i.e., gelatin and poly(ε‐caprolactone) (PCL). Transmission electron microscopy and water contact angle measurements confirmed that a gelatin inner fiber was wrapped with a PCL outer layer. Possible applications of such nanofibers include a controlled degradation rate when used as a medical device in human body. It has been found that the tensile performance of the composite nanofibers was better than those of both the pure constituent, i.e. gelatin and PCL, nanofibers alone. The ultimate strength and ultimate strain of the composite nanofibers with 7.5% w/v gelatin in the core and 10% w/v PCL as shell were at least 68% and 244% higher, respectively, than those of the same concentration pure gelatin and PCL nanofibers. Thus, a coaxial electrospinning technique as used in this article can be applicable, not only in developing functionalized nanofibers but also in elevating their mechanical property. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 2852–2861, 2005
Elastic properties and mechanical relaxation behaviors of PVDF (poly (vinylidene fluoride)) at temperatures between −20 and 100 °C and at 2 MHz ultrasonic frequency
Authors: Guney H. Yuksel 
Published: August 2005

AbstractThe elastic properties of PVDF have been investigated as a function of temperature. The propagation velocity and absorption of longitudinal and transverse ultrasonic waves have been measured at a constant frequency of 2 MHz and temperatures between –20 and 100 °C. Hence, the temperature dependences of storage and loss elastic constants have been obtained for temperatures between –20 and 100 °C. It has been seen that the relaxation behavior is affected from the form of mechanical disturbance. For the longitudinal mode, only one relaxation peak at 42 °C, but for transverse mode three relaxation peaks at 28 °C, 60 °C, and 94 °C have been observed. The results have been compared with the literature values obtained previously for PVDF. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 2862–2873, 2005
Development of HIV fusion inhibitors
Authors: Schneider Stephen E. , Bray Brian L. , Mader Catherine J. , Friedrich Paul E. , Anderson Mark W. , Taylor Tracy S. , Boshernitzan Natalia , Niemi Toivo E. , Fulcher Brian C. , Whight Sheila R. , White Jonathan M. , Greene Reagan J. , Stoltenberg Larry E. , Lichty Maynard 
Published: August 2005

AbstractIn the past 25 years, the worldwide AIDS epidemic has grown such that roughly 38 million people were estimated to be living with the disease worldwide at the end of 2003. The introduction of antiretroviral‐based therapies, beginning in 1987, has enabled many to live with HIV as a chronic, rather than terminal, disease. However, the emergence and spread of drug‐resistant strains highlights the continued need for new therapies with novel modes of action. In 2003, the FDA and EMEA approved enfuvirtide (Fuzeon), a 36 amino acid peptide derived from the natural gp41 HR2 sequence, as the first HIV fusion inhibitor. T‐1249, a 39 amino acid fusion inhibitor, is active against viruses that develop resistance to enfuvirtide. The development of FIs and the processes to manufacture enfuvirtide and T‐1249 on an unprecedented scale for peptide therapeutics are presented. Synthetic routes based on a combination of solid phase peptide synthesis and solution phase fragment condensation as well as the analytical controls necessary to insure a robust process are discussed. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.
Characteristics of excitonic emission in diamond
Authors: Okushi Hideyo , Watanabe Hideyuki , Kanno Shokichi 
Published: August 2005

AbstractThe Editor's Choice [1] is a theoretical study of the excitonic emission properties in diamond, in particular with regard to possible Bose–Einstein condensation (BEC).	The cover picture shows a simple phase diagram for electron–hole pairs in dependence on their density and temperature. It is predicted that exciton BEC does occur for highly excited exciton densities, e.g. on the order of 1018–1019 cm–3, at low temperatures.The first author, Hideyo Okushi, started to study homoepitaxial CVD diamond films for electronic devices in 1995, now at AIST. Since 2001, he has been the leader of the CREST project “Ultraviolet nanodevices using high‐density exciton in diamond”.This issue contains papers presented at SBDD X. This year saw the 10th anniversary of the series of International Workshops on Surface and Bulk Defects in CVD Diamond Films, which are traditionally held in Diepenbeek‐Hasselt, Belgium.
Preface: phys. stat. sol. (a) 202/11
Authors: Bergonzo Philippe , Nesládek Miloš 
Published: August 2005

AbstractThe present issue of physica status solidi (a) contains a collection of 31 papers presented at the 10th International Workshop on Surface and Bulk Defects in CVD Diamond Films held in Diepenbeek‐Hasselt, Belgium, 23–25 February 2005. The 10th anniversary of the meeting proved the success of the concept, which originated in 1996 with the idea of bringing together scientists who are active and innovative in the field of electronic and optical properties of thin film diamond. This year the programme contained 9 invited oral talks, 14 contributed oral talks and 34 posters. 103 Participants from 14 countries (Austria, Belgium, Czech Republic, Finland, France, Germany, Japan, Mexico, Poland, Slovak Republic, Sweden, Switzerland, UK, USA) took part in the meeting. The meeting was traditionally directed towards topics ranging from defects and their characterization as well as electrical transport in CVD diamond towards modern diamond thin film devices including bio‐sensing applications. Also, diamond homoepitaxial and heteroepitaxial growth, doping, hydrogen induced surface conductivity and several other topics including defects in boron nitride materials were addressed. Intense and lively discussions were as usual part of this meeting to which the hospitality of the city of Hasselt contributed greatly.The workshop would have not been possible without the support of many people and institutions. We also acknowledge the financial support of the Scientific Research Community of the F.W.O.‐Vlaanderen (Belgium) and the University of Hasselt. We also thank the editorial staff of physica status solidi, most notably Stefan Hildebrandt, for their excellent and patient work. Finally, we would like to thank Ken Haenen, whose skills for the successful organization are gratefully acknowledged.August 2005
The role and function of quality assurance officers in Ontario hospitals
Authors: Rondeau Kent V. , Birdi Nareshwar 
Published: August 2005

AbstractThis article examines the role and job function of quality assurance officers in hospitals in Ontario, Canada. Results from a mail questionnaire suggest that hospital quality assurance professionals in our sample are much more likely to be female, at mid‐career, and to have advanced graduate degrees, although most lack professional certification and formal training in quality management. Although the job duties of hospital quality assurance professionals are broad and varied, many report being engaged in traditional quality assurance managerial activities including hospital accreditation efforts, risk management assessment, and patient satisfaction measurement. Coordinating quality assurance activities, performance reporting, and leading the Total Quality Management (TQM)/Continuous Quality Improvement (CQI) initiative remain central functions associated with their work efforts. Nevertheless, limited formal training in the principles and methods of quality management and improvement may be placing significant constraints on their effectiveness. Copyright © 2005 John Wiley & Sons, Ltd.
A journey along the 21 CFR Part 11 Life Cycle
Authors: Siconolfi Richard M. 
Published: August 2005

AbstractThe Food and Drug Administration's (FDA) Guidance to Industry on 21 Code of Federal Regulations (CFR) Part 11 attempts to explain how industry can develop work processes that allow flexibility with this regulation without compromising compliance. However, to take advantage of this flexibility, our company needed to clearly understand the impact this guidance could have on our current work processes. We focused our attention on two specific areas: (1) developing and deploying a risk assessment and management process, and (2) revising our Part 11 Life Cycle for computerized systems. Copyright © 2005 John Wiley & Sons, Ltd.
Illness‐related complaints in women with chronic widespread pain: importance of a contextual approach
Authors: Andersson Sven Ingmar , Hovelius Birgitta 
Published: August 2005

AbstractThe study, comprising 125 sick‐listed women aged 25–64 (m = 46.9 years) with widespread chronic pain, aimed at evaluating biopsychosocial problems as perceived by these women, studying such problems within a contextual framework, relating the findings to sociodemographic and medical data. Musculoskeletal complaints, fatigue, inability to work, sleep disturbances and uncertainty about the future were the problems, other than pain, most frequently reported. The women's written accounts of their musculoskeletal or somatic problems reflected being troubled by their unpaid household work and duties. Their psychological symptoms and social problems generally concerned paid work, unemployment or being on sick leave. The women's biomedical orientation appeared to be a function of their extended pharmaceutical and surgical treatment and their efforts to be recognized, particularly by insurance authorities, as clearly having a somatic disease. The study indicates the importance of a situational approach to gaining an understanding of illnesses in women with widespread pain. It is argued that, in a society accepting only medical grounds for sicklisting, physicians and other health care workers serve to reinforce a biomedical perspective in women suffering from biomedically ‘unexplained’ somatic symtoms, tending to result in medicalization, surgery and heavy use of pharmaceutical drugs. Copyright © 2005 John Wiley & Sons, Ltd.
A cost‐based approach to vertical handover policies between WiFi and GPRS
Authors: Calvagna Andrea , Di Modica Giuseppe 
Published: August 2005

AbstractTo implement seamless mobility inside an integrated, multiple (e.g., GPRS/WiFi) access system, a vertical handover policy has to be devised. This is usually done at the mobile terminal, allowing it to be customized from an end‐user's perspective, in order to fit individual needs/preferences. We propose a new approach in taking vertical handover decisions, which are not anymore exclusively based on the knowledge of the available access networks' characteristics but also on higher level parameters which fall in the transport and application layers. To this extent, in this paper a model has been realized and simulations have been run in order to evaluate the impact of the vertical handover and its frequency on a set of typical user's network applications/services. We also take into account the user preferences in terms of cost and quality of service. We believe this approach reflects the optimal settings from the user's point of view with regard to his running services and applications. Our aim is to understand how to define a metric to be used in order to devise a solution which should try to balance the overall cost of vertical handovers with the actual benefits they bring to actual user's networking needs. This way, each mobile user could autonomously apply the handover decision policy, which is more convenient to his specific needs. Copyright © 2005 John Wiley & Sons, Ltd.
A mobile peer‐to‐peer approach for multimedia content sharing using 3G/WLAN dual mode channels
Authors: Kang Seung‐Seok , Mutka Matt W. 
Published: August 2005

AbstractThis paper provides a scheme to reduce the cost to distribute multimedia content to a set of nearby mobile peers, which we call chums. One peer, called the proxy, downloads multimedia content via a telecommunication link, and distributes it (which we call chumcast) to the ad hoc network formed from the set of nearby peers. Each peer in the ad hoc network takes turns serving as a proxy. Every peer is associated with a server that resides in the internet. The server for the proxy, called the active server, manages peer information, schedules the next proxy, selects a set of rebroadcasting peers, and detects partitioning of the ad hoc network. With support from the servers in the internet, peers receive benefits of reduced telecommunication bandwidth, computation power, as well as several security features. Simulation results show that 80% of the telecommunication cost is saved with as few as six peers. Copyright © 2005 John Wiley & Sons, Ltd.