bluuebunny/crossref_metadata_2025_split huggingface dataset:
The acceptability of, and informational needs related to, self‐collection cervical screening among women of Indian descent living in Victoria, Australia: A qualitative study
Authors: Machado Colling Ana , Creagh Nicola S. , Gogia Neha , Wyatt Kerryann , Zammit Claire , Brotherton Julia M. L. , Nightingale Claire E. 
Published: January 2024

AbstractBackgroundIn July 2022, self‐collection became universally available as part of Australia's National Cervical Screening Program. This change aims to address screening inequities experienced among underscreened populations, including women of Indian descent. This study explored experiences of cervical screening, alongside the acceptability of self‐collection, among women of Indian descent living in Victoria, Australia. We also aimed to articulate the informational needs to promote self‐collection among this population.MethodsFive focus group discussions with 39 women living in Victoria were conducted in English (n = 3) and Punjabi (n = 2). Transcripts were thematically analysed, as informed by the Theoretical Framework of Acceptability.ResultsWomen were motivated by the choice to self‐collect, perceiving the ability to maintain modesty and greater autonomy as key enablers. Healthcare practitioners were seen as central in supporting patient‐centred models of care. Perceived barriers to self‐collection included concerns around its accuracy and women's confidence in collecting their own sample. Widespread dissemination of culturally tailored promotion strategies communicating concepts such as 'privacy' and 'accuracy' were suggested by women to promote self‐collection.ConclusionSelf‐collection was highly acceptable among women of Indian descent, particularly when assured of its accuracy, and sociocultural norms and previous screening experiences are considered. This study highlights the huge potential that self‐collection can play in increasing equity in Australia's cervical screening programme.Patient or Public ContributionMembers of the public were involved in focus group discussions. Findings were summarised and disseminated via a poster. A bicultural worker was involved in all stages of the research.
‘We need more support and doctors that understand the process of tapering …’: A content analysis of free‐text responses to a questionnaire on discontinuing long‐term benzodiazepine receptor agonist use
Authors: Lynch Tom , Ryan Cristín , Huff Christy , Foster D. E. , Cadogan Cathal 
Published: January 2024

AbstractBackgroundMany individuals worldwide continue to take benzodiazepine receptor agonists (BZRAs) long term (≥3 months). The aim of this study was to conduct a content analysis of the views and experiences of discontinuing long‐term BZRA use as documented in the free‐text responses of respondents to an online questionnaire examining mediators of behaviour change relating to the discontinuation of long‐term BZRA use.DesignThe questionnaire was disseminated via online BZRA support groups to community‐based adults with either current or previous experience of long‐term BZRA use. The four free‐text questions focused on (1) barriers and (2) facilitators to discontinuing BZRA use; (3) additional supports required to discontinue BZRA use; and (4) additional comments regarding BZRA use. Response data were analysed using summative content analysis.ResultsThe most commonly reported barrier to BZRA discontinuation related to the consequences of stopping the medication, including withdrawal symptoms and the possibility of return of the original symptoms. The most common facilitator that respondents reported would help them in discontinuing BZRA use was support, primarily from medical professionals. Many respondents reported having been harmed or negatively affected in some way because of BZRA use. Several respondents expressed regret over ever taking BZRAs and/or reported that, with the benefit of hindsight, they should never have taken BZRAs in the first instance.ConclusionThe findings highlight the range of barriers faced by those attempting BZRA discontinuation and the importance of additional supports. Holistic and person‐centred approaches are needed to support discontinuation of long‐term BZRA use that considers an individual's personal circumstances and wider social context.Patient or Public Contribution‘Experts by experience’ with previous experience of long‐term BZRA use were involved in developing the questionnaire and writing the manuscript as collaborators. Individuals with lived experience of taking BZRAs completed the questionnaire.
The meaning of the recovery process and its stages for people attending a mental health day hospital: A qualitative study
Authors: Ventosa‐Ruiz Ana , Moreno‐Poyato Antonio R. , Lluch‐Canut Teresa , Feria‐Raposo Isabel , Puig‐Llobet Montserrat 
Published: January 2024

AbstractIntroductionThis study sought to explore the meaning of the recovery process and its stages from the perspective of people attending a mental health day hospital.MethodsA descriptive exploratory qualitative study was carried out. Semi‐structured interviews were conducted with people attending a mental health day hospital. The data were analysed deductively by means of content analysis.ResultsThe participants described the recovery process as a process based on three pillars; the attitude towards recovery, hardship, and the effort required throughout the process. Regarding the stages of recovery, for the participants in the first stage of the process (Moratorium), the search for hope was the most important element. In the second stage (Awareness), the reestablishment of their identity, through the acceptance of the consequences derived from the mental health problem, together with being able to feel full and fulfilled, were the most outstanding elements. In the third stage (Preparation), participants highlighted the search for meaning in life, facing their fears and the process with an open mind. Finally, the last two stages (Rebuilding and Growth) were related to taking responsibility and empowerment for recovery.ConclusionsThe results of this study provide insight into the perception of the recovery process and its stages in people attending a mental health day hospital. These findings may contribute to aligning the nurse–patient perspective, helping nurses to understand the key elements of patients according to their stage of recovery, and thus be able to subsequently individualise interventions.Patient and Public ContributionThis study was based on interviews with 15 patients receiving treatment at an adult mental health day hospital. This study would not have been possible without their participation.
Associations of TACSTD2/TROP2 and NECTIN‐4/NECTIN‐4 with molecular subtypes, PD‐L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts
Authors: Bahlinger Veronika , Branz Annalena , Strissel Pamela L , Strick Reiner , Lange Fabienne , Geppert Carol I , Klümper Niklas , Hölzel Michael , Wach Sven , Taubert Helge , Sikic Danijel , Wullich Bernd , Angeloni Miriam , Ferrazzi Fulvia , Diehl Lauri , Kovalenko Maria , Elboudwarej Emon , Jürgensmeier Juliane M , Hartmann Arndt , Eckstein Markus 
Published: January 2024

AimsTreatment options for advanced urothelial carcinoma (aUC) rapidly evolved: besides immunomodulative therapeutic options and inhibitors targeting Fibroblast growth factor receptor (FGFR) alterations, two new antibody‐drug conjugates (ADC), sacituzumab govitecan (SG) and enfortumab vedotin (EV), have been approved. However, little is known about the associations of specific aUC properties and the surface target expression of TROP2 and NECTIN‐4. Our aim was to characterize associations of TACSTD2/TROP2 and NECTIN‐4/NECTIN‐4 protein and gene expression with morphomolecular and clinicopathological characteristics of aUC in two large independent cohorts.Methods and resultsThe TCGA BLCA (n = 405) and the CCC‐EMN (n = 247) cohorts were retrospectively analysed. TROP2/TACSTD2 and NECTIN‐4/NECTIN‐4 are highly expressed at the protein and transcript level in aUC, and their expression status did not correlate with patient survival in both cohorts. NECTIN‐4/NECTIN‐4 expression was higher in luminal tumours and reduced in squamous aUCs. NECTIN‐4 was negative in 10.6% of samples, and 18.4% of samples had low expression (H‐score <15). The TROP2 negativity rate amounted to 6.5%. TACSTD2 and NECTIN‐4 expression was reduced in neuroendocrine‐like and/or protein‐based double‐negative tumours. TROP2‐ and NECTIN‐4‐negative tumours included one sarcomatoid and four neuroendocrine aUC. FGFR3 alterations and PD‐L1 expression on tumour and immune cells did not associate with TROP2 or NECTIN‐4 expression.ConclusionsTACSTD2/TROP2 and NECTIN‐4/NECTIN‐4 are widely expressed in aUC, independent of FGFR3 alterations or PD‐L1 expression, thus representing a suitable target for ADC treatment in the majority of aUC. The expression loss was associated with aggressive morphomolecular aUC subtypes, i.e. neuroendocrine(‐like) and sarcomatoid aUC.
Employee well‐being outcomes from individual‐level mental health interventions: Cross‐sectional evidence from the United Kingdom
Authors: Fleming William J. 
Published: January 2024

AbstractInitiatives that promote mental well‐being are formally recommended for all British workers, with many practices targeting change in individual workers' resources. While the existing evidence is generally positive about these interventions, disagreement is increasing because of concerns that individual‐level interventions do not engage with working conditions. Contributing to the debate, this article uses survey data (N = 46,336 workers in 233 organisations) to compare participants and nonparticipants in a range of common individual‐level well‐being interventions, including resilience training, mindfulness and well‐being apps. Across multiple subjective well‐being indicators, participants appear no better off. Results are interpreted through the job demands–resources theory and selection bias in cross‐sectional results is interrogated. Overall, results suggest interventions are not providing additional or appropriate resources in response to job demands.
Disclosure specificity: Evidence from book‐to‐bill ratios
Authors: Chapman Kimball , Kaplan Zachary , Potter Chase 
Published: January 2024

AbstractWe investigate whether managers vary disclosure specificity strategically, by examining how the voluntary disclosure of a key performance indicator, the book‐to‐bill (BTB) ratio (the ratio of orders received to orders billed), varies with future firm performance. Consistent with theoretical predictions from prior research, we find that managers are more likely to provide precise BTB disclosures when the news is positive, while offering less precise disclosures when the news is negative. We find that managers strategically vary specificity more when valuation incentives are higher and monitoring is lower. We find that the tone of qualitative descriptions is informative, with or without precise disclosure, inconsistent with the predictions of strategic withholding models. Our results are consistent with persuasion models in which managers vary the specificity of news strategically, to affect the weight stakeholders place on the signal.
New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes of the Japan Diabetes Society (English version)
Authors: Shimada Akira , Kawasaki Eiji , Abiru Norio , Awata Takuya , Oikawa Yoichi , Osawa Haruhiko , Kajio Hiroshi , Kozawa Junji , Takahashi Kazuma , Chujo Daisuke , Noso Shinsuke , Fukui Tomoyasu , Miura Junnosuke , Yasuda Kazuki , Yasuda Hisafumi , Imagawa Akihisa , Ikegami Hiroshi 
Published: January 2024

AbstractThe diagnostic criteria for slowly progressive type 1 diabetes (slowly progressive insulin‐dependent diabetes mellitus; SPIDDM) have been revised by the Committee on Type 1 Diabetes of the Japan Diabetes Society. All of the following three criteria must be met for ‘a definitive diagnosis of SPIDDM’: (1) presence of anti‐islet autoantibodies at some point in time during the disease course; (2) absence of ketosis or ketoacidosis at the diagnosis of diabetes with no requirement for insulin treatment to correct hyperglycemia immediately after diagnosis in principle; and (3) gradual decrease of insulin secretion over time, with insulin treatment required at more than 3 months after diagnosis, and the presence of severe endogenous insulin deficiency (fasting serum C‐peptide immunoreactivity <0.6 ng/mL) at the last observed point in time. When a patient fulfills only (1) and (2), but not (3), he/she is diagnosed with ‘SPIDDM (probable)’ because the diabetes is non‐insulin‐dependent type.
Expectations, beliefs, and perceptions in the modern economy: An overview
Authors: Claus Edda , Dedewanou F. Antoine 
Published: January 2024

AbstractExpectations matter in dynamic models where decisions in one period have implications for outcomes in subsequent periods. Rational expectations were once the dominant assumption but its popularity is waning. Human decision‐making deviates from rationality suggesting important influences of perceptions and beliefs on decision‐making. The articles in this special issue provide up‐to‐date reviews of the importance of expectations, beliefs, and perceptions including the role of social media in shaping them.
Risk factors for antibiotic therapy failure in women with tubo‐ovarian abscess: A systematic review and meta‐analysis
Authors: Kinay Tugba , Akay Arife , Aksoy Munevver , Celik Balkan Fatma , Engin Ustun Yaprak 
Published: January 2024

AbstractAimMedical therapy with antibiotics only and surgical drainage are the treatment options of tubo‐ovarian abscess (TOA). It is not yet known exactly which cases need surgical treatment. The aim of this systematic review and meta‐analysis was to evaluate the risk factors leading antibiotic therapy failure in women with TOA.MethodsWe searched the following databases from inception to June 1, 2022: PubMed, Ovid MEDLINE, The Cochrane Library, and Scopus. We also searched reference lists of eligible articles and related review articles. The observational cohort, cross‐sectional, and case–control studies were included in the meta‐analysis. At least four review authors independently selected eligible articles, assessed risk of bias, and extracted data. The random effect model was used in the meta‐analysis.ResultsA total of 29 studies, including 2890 women, were included in the study. The age, abscess size, history of intrauterine device use, postmenopausal status, history of diabetes mellitus, fever, white blood cell count, erythrocyte sedimentation rate, C‐reactive protein level, and history of pelvic inflammatory disease were found as significant risk factors for antibiotic therapy failure in women with TOA.ConclusionsThe findings of this study clarified the risk factors for antibiotic therapy failure in women with TOA.
Association between household food insecurity and stunting in children aged 0−59 months: Systematic review and meta‐analysis of cohort studies
Authors: Patriota Érika S. O. , Abrantes Lívia C. S. , Figueiredo Ana C. M. G. , Pizato Nathalia , Buccini Gabriela , Gonçalves Vivian S. S. 
Published: January 2024

AbstractHousehold food insecurity (HFI) during childhood is associated with poor dietary diversity and malnutrition, placing children's growth at risk. Children with growth disorders, such as stunting, are more likely to have poor cognition and educational performance, lower economic status, and an increased risk of nutrition‐related chronic diseases in adulthood. Our study aimed to systematically review and conduct a meta‐analysis of cohort studies investigating the association between HFI and stunting in children aged 0−59 months. Peer‐reviewed and grey literature were systematically searched in electronic databases with no language or date restrictions. Two reviewers independently assessed the studies for pre‐established eligibility criteria. Data were extracted using a standard protocol. Random‐effects meta‐analysis models were used, and I2 > 40% indicated high heterogeneity across studies. We used the Grading of Recommendations Assessment, Development, and Evaluation system to assess the quality of the evidence. Nine cohort studies comprising 46,300 children were included. Approximately 80% (n = 7) of the studies found a positive association between HFI and stunting. Pooled odds ratio was 1.00 (95% confidence interval [CI]: 0.87−1.14; I2: 76.14%). The pooled hazard ratio between moderate and severe HFI and stunting was 1.02 (95% CI: 0.84−1.22; I2: 85.96%). Due to high heterogeneity, the quality of evidence was very low. Individual studies showed an association between HFI and stunting in children aged 0–59 months; however, this association was not sustained in the pooled analysis, possibly because of high heterogeneity across studies.
Revisiting the Galant in Gjerdingenian Schemata
Authors: Yu Hainian 
Published: January 2024

ABSTRACTRobert Gjerdingen's schema theory focuses the long‐debated ‘galant’ style concretely onto an inventory of stock musical phrases, or ‘galant schemata’. The rich historico‐cognitive discourse sparked by this growing ‘schematicon’ has provided significant theoretical evidence for their historical situatedness, coherence and objectivity; however, there remains a shortage of empirical studies that problematise their contexts of applicability, as well as descriptiveness within full galant works. In light of this, the present investigation schematically interprets three varied works by the eighteenth‐century composer C. P. E. Bach, who is known for pushing the boundaries of the galant style: theMagnificatin D, Wq. 215;Die Israeliten in der Wüste, Wq. 238 (all applicable movements); and the ‘Württemberg’ Sonatas, Wq. 49 (opening movements). Similar proportions of each vocal work are found to be covered by galant schemata (55 per cent and 46 per cent, respectively), atypical schema variants (17 per cent and 24 per cent respectively) and non‐schematic space (25 per cent each), whilst the ‘Württemberg’ Sonatas yielded more (82 per cent) typical schemata, fewer (3 per cent) atypical schemata and reduced (13 per cent) non‐schematic space. Comparisons and analyses within and between these works and schematic categories reveal potential additions to the galant schematicon; highlight the existence of interactions between galant schemata, higher‐level schemas andpartimentischemata; and elucidate both fluid and strict understandings of Gjerdingen's galant category within eighteenth‐century music. Consequently, they focus the question of schema historicity back onto their galant situatedness and establish an important evidence‐based framework from which the Gjerdingenian galant category – and the schemata which constitute it – may be further elucidated.
Middle Jurassic insect mines on gymnosperms provide missing links to early mining evolution
Authors: Xiao Lifang , Labandeira Conrad C. , Wu Yuekun , Shih ChungKun , Ren Dong , Wang Yongjie 
Published: January 2024

Summary
We investigated the mining mode of insect feeding, involving larval consumption of a plant's internal tissues, from the Middle Jurassic (165 million years ago) Daohugou locality of Northeastern China. Documentation of mining from the Jurassic Period is virtually unknown, and results from this time interval would address mining evolution during the temporal gap of mine–seed plant diversifications from the previous Late Triassic to the subsequent Early Cretaceous.
Plant fossils were examined with standard microscopic procedures for herbivory and used the standard functional feeding group–damage‐type system of categorizing damage. All fossil mines were photographed and databased.
We examined 2014 plant specimens, of which 27 occurrences on 14 specimens resulted in eight, new, mine damage types (DTs) present on six genera of bennettitalean, ginkgoalean, and pinalean gymnosperms.
Three conclusions emerge from this study. First, these mid‐Mesozoic mines are morphologically conservative and track plant host anatomical structure rather than plant phylogeny. Second, likely insect fabricators of these mines were three basal lineages of polyphagan beetles, four basal lineages of monotrysian moths, and a basal lineage tenthredinoid sawflies. Third, the nutrition hypothesis, indicating that miners had greater access to nutritious, inner tissues of new plant lineages, best explains mine evolution during the mid‐Mesozoic.
Nicotinamide employs a starvation strategy against Porphyromonas gingivalis virulence by inhibiting the heme uptake system and gingipain activities
Authors: Lei Zixue , Ma Qizhao , Tu Yeting , Qiu Yang , Gong Tao , Lin Yongwang , Zhou Xuedong , Li Yuqing 
Published: January 2024

AbstractPeriodontitis is a common oral bacterial infection characterized by inflammatory responses. Its high prevalence lowers the quality of life for individuals and increases the global economic and disease burden. As microorganisms in dental plaque are responsible for this oral disease, antibacterial drug treatments are effective strategies for preventing and treating periodontitis. In this study, we investigated the inhibitory effect of nicotinamide (NAM), a vitamin B3 derivative, on the growth and virulence of Porphyromonas gingivalis, a key member of the red complex. Our findings revealed that NAM inhibited bacterial growth and gingipain activities, which played a dominant role in protein hydrolysis and heme acquisition. NAM decreased hemagglutination and hemolysis abilities and changed hemin and hemoglobin binding capacities, controlling bacterial infection through a starvation strategy by blocking access to growth‐essential nutrients from the outside and reducing bacterial virulence. Several experiments in an animal model showed the effectiveness of NAM in preventing alveolar bone loss and reducing inflammatory cell infiltration, shedding light on its potential therapeutic applicability.
Genomic analyses provide insights into sex differentiation of tetraploid strawberry (Fragaria moupinensis)
Authors: Qiao Qin , Cao Qiang , Zhang Rengang , Wu Mingzhao , Zheng Yibingyue , Xue Li , Lei Jiajun , Sun Hang , Liston Aaron , Zhang Ticao 
Published: January 2024

SummaryThe strawberry genus, Fragaria, exhibits a wide range of sexual systems and natural ploidy variation. Nearly, all polyploid strawberry species exhibit separate sexes (dioecy). Research has identified the sex‐determining sequences as roughly conserved but with repeatedly changed genomic locations across octoploid strawberries. However, it remains unclear whether tetraploid wild strawberries evolved dioecy independently or shared a common origin with octoploid strawberries. In this study, we investigated the sex determinants of F. moupinensis, a dioecious plant with heterogametic females (ZW). Utilizing a combination of haplotype‐resolved genome sequencing of the female F. moupinensis, k‐mer‐based and coverage‐based genome‐wide association studies (GWAS), and transcriptomic analysis, we discovered a non‐recombining, approximately 33.6 kb W‐specific region on chromosome 2a. Within this region, only one candidate sex‐determining gene (FmoAFT) was identified. Furthermore, an extensive resequencing of the entire Fragaria genus indicated that the W‐specific region displays conservative female specificity across all tetraploid species. This observation suggests that dioecy evolved independently in tetraploid and octoploid strawberries. Moreover, employing virus‐induced gene silencing (VIGS), we knocked down the expression of the FmoAFT homologue transcript in cultivated strawberries, revealing its potential role in promoting female functions during early carpel development. We also applied DNA affinity purification sequencing (DAP‐seq) and yeast one‐hybrid assays to identify potential direct targets of FmoAFT. These insights shed new light on the genetic basis and evolutionary history of sex determination in strawberries, thereby facilitating the formulation of strategies to manipulate sex determination in breeding programs.