bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined photodynamic and radiodynamic therapy with a chlorine photosensitizer under fractionated radiation exposure to transplanted tumors in an <i>in vivo</i> experiment
Authors: Tzerkovsky D. A. , Mazurenko A. N. , Kozlovsky D. I. , Adamenko N. D. , Borichevsky F. F. 
Published: October 2023

Introduction. The current direction of scientific research in experimental and clinical oncology is radiodynamic therapy (RDT), a treatment method based on the activation of photosensitizers (PS) by ionizing radiation. As the results of in vitro / in vivo studies show, a number of photosensitizing agents have radiomodifying properties, and the method itself is characterized by high antitumor efficacy.Aim. To study the possibility of increasing the effectiveness of photodynamic therapy (PDT) through its combined use with RDT in an in vivo experiment.Materials and methods. The work was performed on 26 white non-linear rats weighing 180 ± 50 g. Pliss lymphosarcoma was used as a tumor model, which was transplanted subcutaneously. The chlorine-based PS (Belmedpreparaty, Republic of Belarus) was administered intravenously at a dose of 2.5 mg / kg of body weight. The RDT session was performed by the contact method (CRT) after 2.5–3, 24 and 48 hours after the end of PS administration on the microSelectron-HDR V3 Digital device (Elekta, Sweden) using γ-radiation (192Ir) in a single focal dose (SFD) of 2 Gy until the total focal dose of 6 Gy is reached. A PDT session was performed once immediately after the first exposure to ionizing radiation using a PDT diode laser (Imaf Axicon, Republic of Belarus, λ = 660 ± 5 nm) at an exposure dose of 100 J / cm² with a power density of 0.2 w / cm² and a power of 0.353 w. All rats were divided into 4 groups of 6–7 animals each: intact control, PS + PDT, PS + CRT, PS + CRT + PDT. The criteria for evaluating antitumor efficacy were: the average volume of tumors (Vav), the coefficient of absolute growth of tumors (K), the coefficient of tumor growth inhibition (TGI), the frequency of complete tumor regressions (CR), the proportion of cured rats, an increase in the average duration of dead rats. Differences were considered statistically significant at p <0.05.Results. On the 18th day of the experiment, Vav in groups was 65.98 ± 0.81 cm³; 24.02 ± 4.01 cm³ (р <0.00001); 17.11 ± 4.13 cm³ (р <0.00001); 4.42 ± 1.65 cm³ (р <0.00001), respectively. Coefficients K – 5497.33 OE; 1714.71 OE; 1424.83 OE; 367.33 OE. TGI coefficients – 63.60 % (PS + PDT); 74.07 % (PS + CRT); 93.30 % (PS + CRT + PDT). An in crease in the average duration of dead rats indicator – 25.31 % (PS + PDT); 55.06 % (PS + CRT); 158.22 % (PS + CRT + PDT). On the 60th and 90th days of the experiment, the frequency of CR and the proportion of cured rats were the same and amounted to 0; 16.7; 14.3 and 42.9 %, respectively.Conclusion. The results obtained indicate that the chlorine PS has, in addition to photosensitizing properties, also radiomodifying properties, and the developed method of combined therapy is characterized by high antitumor efficacy.
Innovation Performance of Nursing: Competence, Motivation and Organizational Commitment as Mediating
Authors: Saryadi  , Liss Dyah Dewi Arini  , Asri Maharani  
Published: October 2023

Background: Attention to open innovation is more important for future research. The impact of the globalization era in health care means that nursing staff are required to be competitive and more professional with the use of increasingly developing technology. Innovation performance is an important determinant of organizational success.
Objective: The substantial for this study is analysing key factors which effect the relationship between competence, motivation to innovate the performance of nursing with organizational commitment as mediating.
Method: This research adopted cross-sectional research. The total respondents in this study was 60 nurses at Jasmine Room RSST Klaten with a census. This study used a hypothesis for applying path analysis, validity reliability for questioner, Statistic-test, and also coefficient determination with correlation.
Results: Path 1 show that competence (Co) and motivation (Mt) have positive significance on organizational commitment (Z). Path 2 shows that competence (Co), motivation (Mt), and organizational commitment (Z) have positive significance. Highlighting the findings, nurse behaviour in innovation is based on competence. The support of hospital organizational commitment has an impact on strengthening nurses' ability in innovation behaviour. Improving the behaviour of nursing personnel in innovating will realize public health needs, and the need for understanding in healthy behaviour. In nursing staff, both those at a young or old age who will retire, competence becomes a factor that cannot be ruled out by funds to innovate. For the motivation, it does not have much meaning for nursing personnel who are old and about to retire.
Conclusion: The spotlight on findings shows the behaviour of nurses in innovation is based on competence. The support of hospital organizational commitment has the impact of strengthening the ability of nurses in innovation behaviour. Increasing the behaviour of nursing personnel in innovating will realize public health needs, and the need for understanding healthy behaviour.
Keywords: Innovation performance, multicultural competence, motivation, organizational commitment.
Learning Goal Orientation (LGO) and Mentor Function Effect on Entrepeneurship Self-Efficacy in Medium Small Enterprises Bojonegoro
Authors: Nurul Mochammad , Eriani Izmi Dwira , Rosyidiana Riska Nur , Chen Yanning 
Published: October 2023

Background: The role of an entrepreneur's internal dispositions and external support mechanisms in influencing self-efficacy remains a subject of keen interest. The Bojonegoro region, with its unique entrepreneurial landscape, provides a rich context for such exploration.
Objective: To unravel the intricate relationships which shape an entrepreneur's self-efficacy, focusing primarily on the contributions of Learning Goal Orientation (LGO) and Mentoring Function (MF).
Method: A questionnaire-based approach was employed targeting 30 small and medium-sized enterprises (SMEs) in Bojonegoro, using the purposive sampling method. The gathered data was meticulously analyzed using SPSS's 25th edition under multiple linear regression analysis.
Results: Findings highlighted the significant positive effect of LGO on Entrepreneur Self-Efficacy. While MF alone did not directly influence self-efficacy, its combined effect with LGO showcased a synergistic positive impact.
Conclusion: The research underscores the importance of both an entrepreneur's learning mindset and effective mentoring in shaping self-efficacy. Emphasizing these factors can offer a more holistic approach to entrepreneurial training and development programs, especially in regions akin to Bojonegoro.
Keywords: Entrepreneur Self-Efficacy, Learning Goal Orientation (LGO), Mentoring Function (MF), Small and Medium-sized Enterprises (SMEs)
Possible role of features of the intestinal microbiome in patients with colorectal cancer as a cause of anastomotic leak
Authors: Kosareva P. V. , Konev R. A. , Godovalov A. P. , Sivakova L. V. , Samodelkin E. I. 
Published: October 2023

Aim. Following the analysis of literature data, to determine significant factors of intestinal obstruction in patients with colorectal cancer.Materials and methods. We analyzed 84 literature sources from the Scopus, Web of Science, Google Scholar, and PubMed databases, as well as open access articles on Google.Results. The predominant causes of anastomotic leaks after operations for colorectal cancer are discussed, the role of the microbiome in the development of postoperative complications is analyzed. The intestinal microbiome of patients with colorectal cancer contains bacteria that are not normally found under physiological conditions. These bacteria contribute to the development of disease, suture failure after surgery for intestinal obstruction, and progression of carcinogenesis. This effect is due to the production of bacterial metabolites, the effect on the human immunity, and competition with obligate intestinal microflora. On the other hand, the use of drug therapy, including antibiotics, leads to mass death of obligate bacteria. Therefore, it is important to search for drugs and treatment methods that, if possible, do not have a significant negative impact on the microbiome, but are capable of destroying pathogenic microorganisms. The concept of Russian authors was proposed, which consists in the intraluminal use of rifaximin-α for the prevention of purulent and septic complications and anastomotic leaks during reconstructive surgeries on the distal colon.
Clinical and prognostic value of leptin resistance in the hospital period of myocardial infarction
Authors: Gorbatovskaya E. E. , Dyleva Ya. A. , Belik E. V. , Uchasova E. G. , Tarasov R. S. , Kashtalap V. V. , Gruzdeva O. V. 
Published: October 2023

Aim. To evaluate the prevalence of leptin resistance (LR) and its clinical and prognostic value in association with metabolic disorders and features of the proinflammatory state in the hospital period of myocardial infarction.Materials and methods. The study included 114 men diagnosed with ST segment elevation myocardial infarction (MI). On day 1 and 12 of MI, the levels of leptin and leptin receptor were measured in patients, and the free leptin index (FLI) was calculated. Leptin resistance (LR) was recorded at leptin > 6.45 ng / ml and FLI > 25. A comparative analysis of clinical and anamnestic characteristics, biochemical parameters, and cardiovascular prognosis was carried out between patients with and without LR. Statistical data processing was carried out using the Statistica 10.0 software package and SPSS 17.0 for Windows.Results. The prevalence of LR in the hospital period of MI was 64%. LR was associated with cardiovascular pathology in the family history, arterial hypertension, dyslipidemia, and obesity. The presence of LR was accompanied by a significant increase in the level of glucose, free fatty acids (FFA), and interleukin (IL)-6 on day 1 of MI and by a significant rise in insulin, C-peptide, tumor necrosis factor (TNF)-alpha, and plasminogen activator inhibitor-1 (PAI-1) throughout the hospital stay. Patients with LR were characterized by multi-vessel and more severe lesions of the coronary bed and were more often subject to early post-infarction angina, recurrent MI, rhythm and conduction disturbances during hospital stay for MI.Conclusion. Patients with MI are characterized by high prevalence of LR during the hospital stay. LR is associated with cardiovascular risk factors, metabolic disorders, formation of insulin resistance, and increased proinflammatory and prothrombogenic factors. The identified features in the presence of LR probably contribute to the development of adverse cardiovascular events in the hospital period of MI.
Metabolic potential of gut microbiota in helminth infections as a way to achieve bronchial asthma control
Authors: Sokolova T. S. , Malchuk V. N. , Zaytseva A. D. , Fedorova O. S. , Karpova M. R. 
Published: October 2023

The aim of the review was to analyze modern experimental studies and clinical trials aimed at assessing metabolic activity of gut microbiota in bronchial asthma (BA) and helminth infections.Being one of the most common chronic heterogeneous respiratory diseases, bronchial asthma secures its place among global health problems of great socioeconomic importance. In recent years, a lot of data has been accumulated indicating that the state of gut microbiota is an important factor determining the state of human health and affecting immune mechanisms underlying the development of allergic diseases in childhood. Dysbiosis of gut microbiota is due not only to changes in its composition, but also to disturbances in its metabolism. In accordance with the “gut – lung axis” concept, maintaining healthy gut microbiota and correcting its disorders, including strategies aimed at activating synthesis of short-chain fatty acids in the intestine, may become a new way to prevent and treat chronic respiratory diseases in childhood. In turn, experimental and epidemiological studies have shown the immunomodulatory activity of helminths. It is assumed that their impact on the composition and function of gut microbiota is one of the mechanisms by which helminths influence the immune response of the host and the course of BA.
Βeta-adrenergic receptor reactivity of erythrocyte membranes in patients with left or right atrial dilatation against the background of atrial fibrillation
Authors: Muslimova E. F. , Popova V. O. , Rebrova T. Y. , Archakov E. A. , Batalov R. E. , Afanasiev S. A. 
Published: October 2023

Hyperactivation of the sympathoadrenal system (SAS) leads to desensitization of β1-adrenergic receptors (β1-AR). This contributes to aggravation of myocardial contractile dysfunction and development of arrhythmias, including atrial fibrillation (AF). An indirect indicator of the viability of β1-AR is β-adrenergic receptor reactivity of erythrocyte membranes (β-ARM).Aim. To evaluate β-ARM in patients with different forms of AF, including left (LAD) or right (RAD) atrial dilation.Materials and methods. The sample included 38 patients, 65.8% of whom had paroxysmal AF, 21% had persistent AF, and 13.2% had long-standing persistent AF. All patients received surgical treatment for AF by radiofrequency ablation or cryoablation. LAD was detected in 39.4% of patients, RAD – in 34.2% of patients. Βeta-ARM was determined before treatment, as well as at 3 days and at 12 months after ablation.Results. The groups of patients with different forms of AF, as well as patients with LAD / RAD and without it showed comparable values of β-ARM at different measurement periods. In the group of patients without LAD / RAD, β-ARM increased 3 days after ablation compared to β-ARM before the treatment (p = 0.002 / p = 0.004) and returned to the pre-treatment level after 3 months. At the same time, in the group of patients with LAD / RAD, β-ARM did not significantly change before the ablation and in different periods after it.Conclusion. In patients with AF without LAD / RAD, we detected an increase in β-ARM 3 days after the ablation compared to the level before the treatment and a decrease in the intensity of SAS 3 months after the surgery. In the presence of LAD / RAD, no changes in the β-ARM were revealed.
Mikhail Zinovievich Vinokurov: Yakut Emigrant, Librarian at the USA Library of Congress
Authors: Maksimova S. V. , Romanova E. N. 
Published: October 2023

The purpose of this study was to reconstruct the personal history of Mikhail Zinovievich Vinokurov (1894-1983), one of the brightest representatives of the Russian intelligentsia of Yakutia, as a biographical narrative. The biography and heritage of M. Z. Vinokurov are considered in the historiography of the topic under study, publications of foreign and Russian researchers. The article reveals the American period of M. Vinokurov life in emigration, cites documents from his collection, transferred in 1983 to the State Library of Alaska (Alaska, USA), copies of which are stored in the National Library of the Republic of Sakha (Yakutia). M. Z. Vinokurov was a writer and public figure who devoted his whole life to enlightenment and creative activity for the benefit of his motherland. While in exile, being a librarian of the US Library of Congress, he initiated and implemented a global project to form the Russian collection of books, ethnographic sources of Siberia, manuscripts, photographs, letters related to Russian America, the Orthodox Church and the literary heritage of the Russian emigration. In this work, he saw his patriot mission. Introduction of Mikhail Vinokurov’s biographical world to the scientific context dictates the need to turn to new archival, visual and personal sources. The article also presents materials on the perpetuation of the memory of M. Z. Vinokurov by the National Library of the Republic of Sakha (Yakutia) in the form of publishing documents from his collection. The plan-prospect of the collection of documents ”The Heritage of Mikhail Zinovievich Vinokurov” in 4 volumes was prepared and approved.The c ollection will become an important step in preserving and promoting the rich cultural heritage of Yakutia and Russia as a whole, as well as in further studying the history of Russian intelligentsia and culture.
Books Published by I. P. Ladyzhnikov Publishing House in German and Other Languages
Authors: Anisimov A. O. 
Published: October 2023

The object of the article is to reveal on the materials from the archive of I.P. Ladyzhnikow Publishing House (1905–1932), found by the author, various aspects of publishing literature in foreign languages.The company was one of the largest Russian-language publishing houses in Berlin, which, in addition to the mass publication of books in Russian, published in large volumes in the first two decades of the 20th century books in foreign languages, mostly in German. They published Russian classical literature, works of contemporary authors. The main volume fell on the works by L.N. Tolstoy, A.M. Gorky, L.N. Andreev. In addition to Russian writers, the company collaborated with various foreign writers. In its activities, the publishing house always respected the rules of copyright in accordance with the rules of the Berne Literary Convention. When translating books into foreign languages, the company interacted with a large number of translators, with some of whom, for example, August Scholz, it had not only literary, but also business relations. The publishing house left a big mark in the history of familiarizing the European reader with the best examples of native literature.
A construção de um podcast sobre a Rainha Jinga
Authors: Dos Santos Maria Emilia Vasconcelos , Barbosa Vitor Matheus de Araújo , De Sá Leitão Yasmin Christine Coutinho 
Published: October 2023

O presente artigo é um relato acerca da pesquisa, elaboração e aplicação de um podcast acerca da personagem histórica “Rainha Jinga”, realizado junto às turmas de 2º Ano do Ensino Médio da Escola Técnica Estadual Dom Bosco, em Recife, Pernambuco. A ação foi desenvolvida por estudantes participantes do Programa Institucional de Bolsa de Iniciação à Docência, da Universidade Federal Rural de Pernambuco. Apresentamos, neste texto, o arcabouço teórico consultado para a produção do podcast, o próprio processo de construção desse material e os resultados e perspectivas concebidos não só após a aplicação do podcast, como também de um questionário interessado em entender o nível de compreensão dos estudantes e os elos criados nessa complexa relação entre passado e presente.
Synthesis, Spectroscopy and Biological Activity Study of Some New Complexes with Schiff Base Derived From Malonic Acid Dihydrazide with 2-pyridine Crboxaldehyde
Authors: Hammoda Rehab Ghalib , Shaalan Naser 
Published: October 2023

تم تحضير ثلاث معقدات جديدة Ni (II)و Cu (II) و Zn (II) باستخدام الليكند المحضر الجديد من تفاعل حامض مالونيك ثنائي هيدرازايد مع 2-بيريدين كربوكسالديهايد. حيث شخصت المعقدات لمحضرة وكذلك الليكند باستخدام تقنيات مختلفة مثل FT-IR و UV-Vis و Mass و 1H-NMR و 13C-NMR وتحليل العناصر CHN و تقدير محتوى الكلور والموصلية المولارية والحساسية المغناطيسية والامتصاص الذري لتشخيص هذه المركبات. لكل معقد محضر جديد من النيكل والنحاس والزنك ، كشفت نتائج التشخيص عن معقدات ذات شكل هندسي ثماني السطوح سداسي التناسق. تمت دراسة تأثير المواد المحضرة على الفعالية البيولوجية لاثنين من البكتريا موجبة الغرام Staphylococcus aureus و Bacillus subtitles واثنين من البكتيريا سالبة الجرام Escherichia coli و Pseudomonas aeruginosa ، بالإضافة إلى candida fungusاثبتت جميع المركبات المحضرة قابلية تثبيطيه جيدة باستثناء معقد النيكل، الذي فشل في إحداث أي تأثيرات مثبطة فعالة ضد pseudomonas.
Population estimation of the Euphrates softshell turtle Rafetus Euphraticus in the Central Marshes (UNESCO site)
Authors: Taher Samer Ammar , Abdulhay Hind Suhail 
Published: October 2023

تم تصنيف ترسة الفرات ملساء الصدفة Rafetus euphraticus على أنها مهددة بخطر الانقراض ضمن القائمة الحمراء للاتحاد الدولي لحفظ الطبيعة، ويُعتقد أنها تعرضت لانخفاض كبير في أعدادها مؤخرًا. تقتصر معلومات الأنواع في العراق على عدد قليل من المسوحات السريعة مع القليل من المعلومات التفصيلية عن التربية والتوزيع. هدفت الدراسة الى تقدير اعداد سلاحف الفرات ملساء الصدفة في الأهوار الوسطى باستخدام استقراء بسيط للعدد. تم استخدام طريقة المربع (بحجم 5 كم2 لكل منهما) لتسجيل توزيع سلحفاة الفرات ملساء الصدفة داخل موقع الدراسة وتم إجراء عشرة مسوحات ابتداءا من شهر تشرين الاول 2021 إلى ايلول 2022 باستثناء موسم السبات (كانون الاول وكانون الثانيو شباط). تم تسجيلها داخل المياه عن طريق وضع الشباك في مناطق معينة بالأهوار الوسطى. اقترح الاستقراء البسيط لتعداداتنا لكامل الأهوار الوسطى أن يبلغ الحد الأقصى لحجم المجاميع السكانية 2526.55 فردًا /المساحة الكلية) 219.700 هكتار.( تعتبر الأهوار الوسطى موقعًا مهمًا لـ R. euphraticus حيث تم تسجيل إجمالي 46 فردًا.
Recurrency on the Space of Hilbert-Schmidt Operators
Authors: Moosapoor Mansooreh 
Published: October 2023

في هذا البحث, تم برهان بانه اذا كانت شبه الزمرة-C0 فوضوية وزائدة او فائقة الاختلاط فان الضرب من جهة اليسار المرتبط بشبه الزمرة-C0 في فضاء مؤثرات هلبرت-شميدت متكرر اذا وفقط اذا كان مفرط الدوران. كذلك, تم بيان انه في ظل بعض الشروط يكون تكرار شبه الزمرة-C0 وتكرار الضرب لشبه الزمرة-C0 من جهة اليسار المرتبط بها في فضاء مؤثرات هلبرت-شميدت متكافئين. علاوة على ذلك, بعض الشروط الكافية للتكرار وزيادة الدوران للضرب من جهة اليسار لشبه الزمرة -C0 تم عرضها بالاعتماد على المجموعات الجزئية المتشعبة.
Photo Degradation of Solochrom Violet Dye by ZnO: Experimental and Theoretical Study
Authors: Hamed Ameera Hassan , Mahmmood Zahraa A. , Hussein Ennas Abdul , Kadhim Mustafa M. 
Published: October 2023

يشمل العمل الحالي التحلل الضوئي للصبغة البنفسجية سولوكروم باستخدام عمليات اكسدة متقدمة عند درجة حرارة ℃25 باستخدام الاشعة فوق البنفسجية H2O2 . تم اجراء التحفيز الضوئي لصبغة سولوكروم البنفسجية عند الطول الموجي 570 نانومتر مع ZnO. تم دراسة تاثير عوامل مختلفة وهي تركيز الصبغة ,درجة الحموضة ,والتركيز الاولي لماادة بيروكسيد الهيدروجين ,وقت التشعبع . ودراسة الحركية على فترات مختلفة كما تم دراسة نسب التحلل بشكل عام.وجد ان معدلات التحلل الضوئي للصبغة كانت اعلى في وجود H2O2و ZnO مع الاشعة فوق البنفسجية .تم تحديد الطول الموجي الافضل . اثبتت عمليات الاكسدة المتقدمة فعاليتها العالية في تحلل معظم الملوثات في مياه الصرف الصحي . تم استخدام مقياس الطيف الضوئي لمراقبة التحلل الضوئي للصبغة .ركزت الحسابات النظرية على المواقع النشطة باستخدام طريقة the density functional theory في برنامجGaussian .