Endometriosis-related infertility: severe pain symptoms do not impact assisted reproductive technology outcomes
Authors: Maignien C , Bourdon M , Parpex G , Ferreux L , Patrat C , Bordonne C , Marcellin L , Chapron C , Santulli P 
Published: December 2023

Abstract

STUDY QUESTION
Do severe endometriosis-related painful symptoms impact ART live birth rates?

SUMMARY ANSWER
Severe pain symptoms are not associated with reduced ART live birth rates in endometriosis patients.

WHAT IS KNOWN ALREADY
ART is currently recognized as one of the main therapeutic options to manage endometriosis-related infertility. Presently, no data exist in the literature regarding the association between the core symptom of the disease, e.g. pain and ART reproductive outcomes.

STUDY DESIGN, SIZE, DURATION
Observational cohort study of 354 endometriosis patients, who underwent ART at a tertiary care university hospital, between October 2014 and October 2021. Diagnosis of endometriosis was based on published imaging criteria using transvaginal sonography and magnetic resonance imaging, and histologically confirmed in women who had a previous history of endometriosis surgery (n = 127, 35.9%).

PARTICIPANTS/MATERIALS, SETTING, METHODS
The intensity of painful symptoms related to dysmenorrhea (DM), dyspareunia (DP), noncyclic chronic pelvic pain, gastrointestinal (GI) pain, or lower urinary tract pain was evaluated using a 10-point visual analog scale (VAS), before ART. Severe pain was defined as having a VAS of 7 or higher for at least one symptom. The main outcome measure was the cumulative live birth rate (CLBR) per patient. We analyzed the impact of endometriosis-related painful symptoms on ART live births using univariable and multivariate analysis.

MAIN RESULTS AND THE ROLE OF CHANCE
Three hundred and fifty-four endometriosis patients underwent 711 ART cycles. The mean age of the population was 33.8 ± 3.7 years, and the mean duration of infertility was 3.6 ± 2.1 years. The distribution of the endometriosis phenotypes was 3.1% superficial endometriosis, 8.2% ovarian endometrioma, and 88.7% deep infiltrating endometriosis. The mean VAS scores for DM, DP, and GI pain symptoms were 6.6 ± 2.7, 3.4 ± 3.1, and 3.1 ± 3.6, respectively. Two hundred and forty-two patients (68.4%) had severe pain symptoms. The CLBR per patient was 63.8% (226/354). Neither the mean VAS scores for the various painful symptoms nor the proportion of patients displaying severe pain differed significantly between patients who had a live birth and those who had not, based on univariate and multivariate analyses (P = 0.229). The only significant factors associated with negative ART live births were age &gt;35 years (P &lt; 0.001) and anti-Müllerian hormone levels &lt;1.2 ng/ml (P &lt; 0.001).

LIMITATIONS, REASONS FOR CAUTION
The diagnosis of endometriosis was based on imaging rather than surgery. This limitation is, however, inherent to the design of most studies on endometriosis patients reverting to ART first.

WIDER IMPLICATIONS OF THE FINDINGS
Rather than considering a single argument such as pain, the decision-making process for choosing between ART and surgery in infertile endometriosis patients should be based on a multitude of aspects, including the patient’s choice, the associated infertility factors, the endometriosis phenotypes, and the efficiency of medical therapies in regard to pain symptoms, through an individualized approach guided by a multidisciplinary team of experts.

STUDY FUNDING/COMPETING INTEREST(S)
No funding; no conflict of interest.

TRIAL REGISTRATION NUMBER
N/A.