bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sovateltide (ILR-1620) improves motor function and reduces hyperalgesia in a rat model of spinal cord injury.
Authors: Mavridis Theodoros , Mavridi Artemis , Karampela Eleftheria , Galanos Antonis , Gkiokas George , Iacovidou Nicoletta , Xanthos Theodoros 
Published: October 2023

Abstract
Background: Spinal Cord Injury (SCI) presents a major global health challenge, with rising incidence and substantial disability. While progress has been made in understanding SCI's pathophysiology and early management, there is still a lack of effective treatments to mitigate long-term consequences. This study investigates the potential of sovateltide, a selective endothelin B (ETB) receptor agonist, in improving clinical outcomes in an acute SCI rat model.
Methods: Thirty male Sprague-Dawley rats underwent sham surgery (Group A) or spinal cord injury (SCI) and treated with vehicle (Group B) or sovateltide (Group C). Clinical tests, including Basso, Beattie, and Bresnahan (BBB) scoring, inclined plane, and allodynia testing with Von Frey Hair, were performed at various time points. Statistical analyses assessed treatment effects.
Results: Sovateltide administration significantly improved motor function, reducing neurological deficits and enhancing locomotor recovery compared to vehicle-treated rats, starting from day 7 post-injury. Additionally, the allodynic threshold improved, suggesting anti-nociceptive properties. Notably, the sovateltide group demonstrated sustained recovery, and even reaching pre-injury performance levels, while the vehicle group plateaued.
Conclusions: This study suggests that sovateltide may offer neuroprotective effects, enhancing neurogenesis and angiogenesis. Furthermore, it may possess anti-inflammatory and anti-nociceptive properties. Future clinical trials are needed to validate these findings, but sovateltide shows promise as a potential therapeutic strategy to improve functional outcomes in SCI. Sovateltide, an ETB receptor agonist, exhibits neuroprotective properties, enhancing motor recovery and ameliorating hyperalgesia in a rat SCI model. These findings could pave the way for innovative pharmacological interventions for SCI in clinical settings.
Design and Performance of Bionic Multi-level Porous Structures Generated by 3D Printing
Authors: zhang guoqing , Li Junxin , Zhou Xiaoyu , Zhou Yongsheng , Xie Juanjuan , Huang Aibing 
Published: October 2023

Abstract
To obtain high-performing biological fixation implants with excellent properties, it is necessary to comprehensively characterize the design method and molding process of new porous structures printed using 3D technology. We adopted parametric modeling to design a bionic multi-level porous structure, evaluated the properties of the porous structure with finite element method, and optimized the design parameters. Finally, the properties of the 3D printed porous structure were characterized by a compression experiment and fractal theory. The results indicate that the porous structure designed by parametric modeling exhibits a good modeling effect. When a traditional porous structure is stressed, the stress mainly concentrates on the longitudinal bar, while the transverse bar is less stressed. In multi-level porous structures, the stress distributions of longitudinal and transverse bars are relatively uniform. No obvious molding defects were detected in the prepared porous structures. The interlaminar fracture mechanism of traditional porous structure is brittle fracture and the fracture mechanism of multi-level porous structure is elastic fracture. The modulus of elasticity and compressive strength increases with the increase of mean pore size and surface-to-volume ratio, and decreases with the increase of porosity. These results present a foundation for 3D printing of high-performing biological fixation implants.
Synergistic Effect of Nitrogen-Fixing Bacteria and Nitrogen Levels on Mung bean (Vigna radiata L.) Growth and Yield
Authors: zahoor Ayesha , Ahmed Uzair , Masud Hamza , Bayar Jalal , Ahmad Haseeb , khan Waleed 
Published: October 2023

Abstract
Mung bean holds significance as a vital leguminous crop, cultivated for its nutritional value and economic importance. This research delved into the impacts of nitrogen-fixing bacteria and varying nitrogen levels on the growth and yield of mung bean. The study was conducted at the Cereal Crop Research Institute (CCRI) in Pirsabak, Nowshera, employing RCB design comprising three repeats. Several agronomic and soil parameters were studied. The first factor was nitrogen fixing bacteria having control, Azotobactor, Azospirillum and Rhizobium and the second factor was nitrogen levels having N1 i.e. control (0 kg ha− 1), N2 (30 kg ha− 1) N3 (60 kg ha− 1), and N4 (90 kg ha− 1). The results revealed that emergence m− 2 of mung bean were not significantly affected by either nitrogen fixing bacteria or nitrogen levels. However, all the other parameters were significantly affected by both nitrogen fixing bacteria and nitrogen levels. Yield attributes, including branches plant− 1, plant height, pods plant− 1, seeds pod− 1, nodules plant− 1, thousand seed weight and seed protein were the highest when crop was treated with Rhizobium as compared to other inoculants. Similarly, the highest seed yield was obtained from Rhizobium treatment (842 kg ha− 1) whereas control produced (715 kg ha− 1). Biological yield was also highest with Rhizobium treatment (4277 kg ha− 1) and lowest was recorded for the control (3790 kg ha− 1). As for nitrogen levels, most of the yield attributes improved and recorded statistically similar values when N3 and N4 were administered. For instance, N4 and N3 produced (867 and 846 kg ha− 1, respectively) seed yield that produced significantly higher seed yield than the control (677 kg ha− 1). Similar to this, biological yield was also higher at N4 and N3 producing (4251 and 4236 kg ha− 1, respectively), while plots having no nitrogen recorded lowest biological yield (3740 kg ha− 1). Moreover, soil analysis revealed that soil total nitrogen improved substantially with increasing N dose, while slight changes in soil pH was seen. Hence, it can be inferred that the utilization of Rhizobium in conjunction with a nitrogen application at a rate of (60 kg ha− 1) can potentially enhance growth and yield of the mung bean.
Advanced bifunctional bionic neural network-like architecture constructed by multi-scale carbon nanotubes nanocomposites
Authors: Li Shuaizhen , Xie Tianwen , Ma Lin , Liu Daheng , Huang Nan , Liu Wei , Li Bing , Gai Zhigang , Jiang Xin , Ma Song , Zhang Zhidong 
Published: October 2023

Abstract
Accompanied with challenging to develop bifunctional electromagnetic wave (EMW) absorbers to enhance the environmental adaptability and survivability of electromagnetic devices in harsh environment, a three-dimensional (3D) hierarchical bionic neural network-like architectures decorated multi-scale Ni3Fe@N-doped carbon nanotube composites (Ni3Fe@NCNT@CF) were innovatively designed and constructed to realize the integration of microwave absorption and corrosion protection. The optimal Ni3Fe@NCNT@CF demonstrates competitive EMW absorption with a minimum reflection loss of −51.5 dB and a maximum effective absorption bandwidth (EAB) of 6.4 GHz at 10 wt%, due to superior interlinked conductive channels (with dominant and adjustable conduction loss) and magnetic-dielectric matching of the 3D hierarchical bionic neural network. A reliable anti-corrosion performance is further exhibited to show ultra-low corrosion current density ~10-8 A·cm-2 after 30 days of immersion in corrosive medium, owing to the physical shield provided by the impermeable and inert CNT shells. Our findings may provide design inspiration of versatile EMW materials for applications in complicated environments.
Research on 3D printing composite material mechanical properties-characterization of robust soft-matter robots
Authors: Farid Muhammad Imran , Wu Wenzheng , WeiGui Li , Zhao Yu 
Published: October 2023

Abstract
The research aims to develop an affordable, user-friendly composite material with mechanical flexibility, durability, and wear-resistant, properties for soft actuation to maintain its functionality and performance over time. In order to reach this goal, the experimental activities were specific into the following tasks: (a) material pre-selection; (b) design of the experiment; (c) specimen preparation (extrusion process) and (d) mechanical properties and material characterization. This research explores the utilization of regular thermoplastic polyurethane (TPU) in combination with electric-conductive thermoplastic polyurethane (TPU/E-TPU) to achieve enhanced flexibility and electrical conductivity. However, there is no doubt that composite materials are advanced materials with superior properties. Among the materials examined, the composite demonstrates exceptional mechanical performance, boasting highest recorded flexural strength at 62 Mpa and modulus of 2.7 GPa, along with a notable tensile strength of 38 MPa and tensile modulus of 2.9 GPa, surpassing both E-TPU and TPU materials. Among the materials examined, boasting highest recorded flexural strength at 35 Mpa and modulus of 2.7 GPa, along with a notable tensile strength of 38 MPa, elastic modulus 2.9 GPa and fracture strain is 480%, surpassing both E-TPU and TPU materials. SEM-EDS and microstructural analyses show excellent mechanical act of the composite. The focus is on creating soft-responsive properties that change under different conditions and stresses, which is crucial for designing reliable soft-matter robots. Which is suitable for soft robotics, wearables electronics, aerospace, medical devices and other manufacturing applications requiring flexible movement.
Impact of the Enhanced Recovery After Surgery (ERAS) Protocol on 3-Year Survival and Outcomes Following Esophagectomy: A Retrospective Cohort Study of 132 Patients
Authors: Chen Szu-Jung , Shen Ching-Hui , Chuang Cheng-Yen , Chang Yi-Ting 
Published: October 2023

Abstract
Introduction
The benefits of the Enhanced Recovery After Surgery (ERAS) protocol are well-documented across surgeries, but its impact on esophageal cancer surgery remains understudied. This study compares 3-year survival rates in esophagectomy patients treated with and without ERAS at a tertiary care hospital.
Methods
A retrospective analysis of 132 esophagectomy patients (Jan 2017- Jan 2022) was conducted. Patients treated before 2019 (n = 66) received standard care, while those from 2019 onwards (n = 66) followed the ERAS protocol. Survival associations were determined using the Kaplan–Meier method and log-rank tests. Multivariate analysis identified potential survival prognostic factors. The primary outcome was 3-year overall survival and secondary outcomes were postoperative intensive care unit (ICU) stay, hospital length of stay (LOS), and complications.
Results
ERAS patients had significantly shorter ICU stay (mean difference: -2.3 days, p < 0.001), reduced hospital LOS (mean difference: -4.9 days, p < 0.001) and fewer postoperative pulmonary complications (0% vs. 13.6%, p = 0.002). The 3-year survival rate was higher in the ERAS group (70.16% vs. 45.29%, p = 0.028). Advanced tumor stage (III-IV) was a significant negative prognostic factor (hazard ratio = 3.08, 95% CI: 1.43–6.67, p = 0.004). Subgroup analysis showed survival benefits were most pronounced in patients with preoperative albumin < 4 g/dl, early-stage tumors (I-II), and aged < 65.
Conclusions
ERAS protocol implementation in esophagectomy was associated with enhanced 3-year overall survival, particularly in patients with low albumin levels, early clinical stages, and aged < 65 years. These findings underscore the potential for ERAS protocols to revolutionize esophageal cancer treatment, leading to improved patient outcomes and more efficient healthcare delivery.
A new winter wheat genetic resource harbours untapped diversity from synthetic hexaploid wheat.
Authors: Wright Tally I C , Horsnell Richard , Love Bethany , Burridge Amanda J , Gardner Keith A , Jackson Robert , Leigh Fiona J , Ligeza Aleksander , Heuer Sigrid , Bentley Alison R , Howell Philip 
Published: October 2023

Abstract
The allelic richness harboured in progenitors of hexaploid bread wheat (Triticum aestivum L.) is a useful resource for addressing the genetic diversity bottleneck in modern cultivars. Synthetic Hexaploid Wheat (SHW) is created through resynthesis of the hybridisation events between the tetraploid (Triticum turgidum subsp. durum) and diploid (Aegilops tauschii) bread wheat progenitors. We developed a large and diverse winter wheat Nested Association Mapping (NAM) population (termed the NIAB_WW_SHW_NAM) consisting of 3241 genotypes derived from 54 nested back-cross 1 (BC1) populations, each formed via back-crossing a different primary SHW into the UK winter wheat cultivar ‘Robigus’. The primary SHW accessions were created using 15 T. durum donors and 47 Ae. tauschii accessions that spanned the lineages and geographical range of the species. Primary SHW parents were typically earlier flowering, taller and showed better resistance to yellow rust infection (Yr) than ‘Robigus’. The NIAB_WW_SHW_NAM population was genotyped using a single nucleotide polymorphism (SNP) array and 27 Quantitative Trait Loci (QTLs) were detected for flowering time, plant height and Yr resistance. Across multiple field trials, a QTL for Yr resistance was found on chromosome 4D that corresponded to the Yr28 resistance gene previously reported in other SHW accessions. These findings highlight the value of the NIAB_WW_SHW_NAM population for genetic mapping and provide the first evidence of Yr28 working in current UK environments and genetic backgrounds. These examples, coupled with the evidence of commercial wheat breeders selecting promising genotypes, highlights the potential value of the NIAB_WW_SHW_NAM to variety improvement.
Saphenous Vein Tributaries in Sequential Vein Grafting for Coronary Artery Disease
Authors: Lanka Santh Prakash , Rai Guruprasad , Maramreddy Revanth , Bishnoi Arvind Kumar , Kumara Vijay , Sevagur Ganesh Kamath 
Published: October 2023

Abstract
Background
Sequential vein grafting is utilized to revascularize multiple distal vascular territories in patients with diffusely diseased coronaries undergoing repeat coronary artery bypass grafting (CABG). However, sequential vein grafting is technically challenging due to the side-to-side anastomosis. This study expands on the usage of saphenous vein tributaries in sequential vein grafting (tributary technique) and its outcomes at a single institution.
Methods
A retrospective observational chart review was conducted on patients who underwent the proposed technique in our institution over three years. The primary outcome variables included all-cause mortality and freedom from major adverse cardiovascular events (MACE). A descriptive analysis was conducted to express the continuous variables as mean and standard deviation and categorical variables as frequency and percentages.
Results
The study included 187 patients with a mean follow-up duration of 24.8 ± 10.0 months and operative mortality of 1.7%. A total of 131 patients remained symptom-free starting from the date of surgery, and four cardiovascular mortalities were reported during the follow-up period.
Conclusion
The tributary technique is feasible and can be a potential option in repeat CABGs requiring multiple grafts in patients with adequate vein calibre in lower limbs.
Association between intake of health foods/supplements and long-term care in the general elder population: the Yamagata cohort study
Authors: Miharu Maya , Suzuki Natsuko , Sho Ri , Osaki Tsukasa , Souri Masayoshi , Watanabe Masafumi , Ueno Yoshiyuki , Konta Tsuneo 
Published: October 2023

Abstract
Background: In recent years, the number of people who consume health foods and supplements has increased owing to growing health consciousness. However, the association between health foods/supplements intake and long-term care in the general elder Japanese remains unclear.
Methods: In this prospective cohort study, we surveyed the intake of health foods/supplements among 8,718 community health checkup participants aged 65 years and over (49.7% men; mean age, 69.3 years) and examined the association between the intake of health foods/supplements and incidence of long-term care during a 9-year follow-up period.
Results: Health foods/supplements intake was observed in 2,092 subjects (24.0%). Compared to the non-intake group, the health foods/supplements intake group showed a higher prevalence of women; a lower prevalence of smoking, alcohol consumption, comorbidities, and its medication. The most frequent health foods/supplements were vitamins, plants, and chondroitin-glucosamine/collagen. During follow-up period the incident long-term care occurred in 291 subjects (3.3%). In competing risk analysis, adjusted for confounding factors, the intake of 3 or more types of health foods/supplements was significantly associated with incidence of long-term care. The association between specific type of health foods/supplements and incidence of long-term care was not observed.
Conclusions: This study reports a high prevalence of health foods/supplements intake and the association between the intake of multiple health foods/supplements and the incidence of long-term care in the general elder population in Japan. This finding indicates that the caution is required in taking many health foods/supplements without adequate information.
Potential profiling of self-management skills in older comorbid patients
Authors: Wu Lanxin , Zhang Yan , Tian Yutong , Liu Li , Meng Lixue , Zhao Ting 
Published: October 2023

Abstract
Background Under the general trend of global aging, geriatric comorbidity is increasingly common andmay have some impact on the quality of life of older people. Self-management can effectively improve patient compliance and subjective initiative and improve patient quality of life. Therefore, this study's classification of older people with comorbidities through latent profile analysis could provide a reference for later personalized intervention programs for the self-management characteristics of older people with different comorbidities.
Objective Based on latentprofile analysis, we aimed to understand the categoricalcharacteristics of the self-management level of older comorbidpatients and to explore the influencing factors of the self-management level of different categories of older comorbid patients.
Method Through a cross-sectional study, 616 older comorbid patients in three districts of Zhengzhou City, Henan Province, were selected as survey subjects by using the whole cluster sampling method. The General Information Questionnaire, Chronic Disease Self-Management Scale, Health Literacy Scale, Electronic Health Literacy Scale, Collaborative Social Support Scale, and Health Empowerment Scale were used to conduct the survey.The resultsof latent profile analysis show that the self-management characteristics of older comorbid patients should be classified into 3 categories: good self-management (19.4%), moderate self-management-low lifestyle (27.9%), and low self-management (52.7%). The results of multivariate logistic regression analyses show that literacy, religiosity, health literacy, e-health literacy, appreciative social support, and health empowerment are influential factors for self-management among older comorbidpatients (P < 0.05).
Conclusion There is obvious heterogeneity in the self-management level of older comorbid patients, and it is recommended that healthcare professionals provide targeted interventions for their weaknesses according to the self-management characteristics of different categories of patients to enhance the self-management level of this population and improve their quality of life.
The combined use of erythropoietin and iron preparations for the management of postpartum anemia: a systematic review and meta-analysis
Authors: Barkovskaya Natalya A. , Shifman E. M. , Protsenko D. N. 
Published: October 2023

INTRODUCTION: There are limited data on the effectiveness of erythropoietin in combination with oral ferrotherapy for the management of postpartum anemia. OBJECTIVE: To evaluate the efficacy of erythropoietin in combination with oral iron compared with oral ferrotherapy in puerperas with postpartum haemorrhage. MATERIALS AND METHODS: MEDLINE, Scopus, EBSCOhost and 5 other databases (January 1980 to February 2023) were searched for articles on the use of oral iron in combination with and without erythropoietin for the treatment of post-hemorrhagic anemia in puerperas. Primary outcomes: hemoglobin level, hemoglobin increase, hematocrit, number of blood transfusions, secondary outcomes: ferritin level, serum iron, lactation capacity. The analysis was carried out in accordance with the PRISMA guidelines, 2020. RESULTS: 4 studies were analyzed, 198 women were included. When using erythropoietin in combination with oral ferrotherapy, the cumulative value of the increase in hemoglobin concentration after 5 days, 2 weeks of treatment was significantly higher compared with the control group (mean difference [MD]: 11.83 g/L, 95% CI 4.43–19.23; р = 0.002, MD 10.13 g/L, 95% CI 4.97–15.29; р = 0.0001), respectively. The cumulative mean hemoglobin concentration after 40 days of treatment was significantly higher in the erythropoietin group (MD 11.00 g/L, 95% CI 1.70–20.30; р = 0.02). The cumulative mean hematocrit after 2 weeks of treatment was significantly higher in the erythropoietin group (MD 3.35 %, 95% CI 0.31–6.39; р = 0.03). The use of erythropoietin in combination with oral iron reduces the likelihood of blood transfusion (relative risk 0.12, 95% CI 0.02–0.95; р = 0.04). CONCLUSIONS: A faster hematological response was shown with the combined use of erythropoietin with oral ferrotherapy compared with monotherapy with iron preparations in the management of postpartum anemia. Further studies with sufficient sample sizes are required.
Demonstration of real-time monitoring in smart graded-water supply grid: an institutional case study
Authors: Singh Shobhana , Choudhary Manoj , Sørensen Kim 
Published: October 2023

Abstract

Real-time information on water supply and quality is a crucial asset for planning and managing water resources, infrastructure, and scientific research for sustainable development. In this direction, the innovative concept of smart water infrastructure is progressing. The present paper reports a case study on the demonstration of a `smart graded-water supply grid' on the campus of the Indian Institute of Technology Jodhpur, India. The paper describes the transformation of ∼13 km long water distribution network that supplies drinking water to ∼5,000 inhabitants into smart supply grid by deploying sensors and establishing an IoT-enabled real-time monitoring platform. The data sets of water flow and pressure collected from sensor nodes are analyzed to understand the characteristic diurnal water usage profiles unique to student hostels on the campus. The data show a distinctive consumption profile of student hostels over the weekdays with a maximum peak consumption of 16.38 m3/h. Monitoring of vital quality parameters such as chlorine, pH, and temperature demonstrate acceptable levels thereby ensuring compliance with safety standards. The purpose of the paper is to provide insights from a real-world case and close the knowledge gap between general awareness and the potential of smart water grid in sustainable management of graded-water services.