bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic submucosal dissection of colorectal lesions assisted with double elastic rings：a case series
Authors: Sun Xin , Zhai Wenzhe , Zhang Shuaiqing , Song Yanjun , Li Ruyuan 
Published: December 2023

Abstract
Background: Endoscopic submucosal dissection (ESD) has become the preferred treatment for early mucosal lesions in the gastrointestinal tract. A clear surgical field of view is crucial for the safety of endoscopic surgery. The development of various traction technologies has simplified the procedure, reduced operation time, and decreased the occurrence of adverse events. Double elastic rings traction is particularly effective in exposing the submucosal layer, expediting the dissection process, and reducing complications, especially for large lesions in the proximal colon.
Methods: This retrospective study included patients with colorectal lesions who underwent ESD treatment at Qilu Hospital of Shandong University from January 2021 to June 2023. The selection of patients was based on the use of the double elastic rings traction method during the operation. Data regarding lesion location, dissection time, resection speed, pathological analysis, complications, secondary surgery, R0 resection, and curative resection were retrospectively analyzed.
Results: The study consisted of 10 patients. The average maximum diameter of the specimens was 43±11mm, with a procedure duration and resection speed of 19.77±5.11mm^2/min, respectively. All lesions were completely resected in a single attempt, and there were no instances of wound perforation or delayed hemorrhage. One patient required secondary surgery, and another received hematology treatment. Eight lesions achieved R0 resection and curative resection.
Conclusion: The use of double elastic rings traction during ESD can provide a wider field of view and reduce complications. Therefore, double elastic rings traction should be considered for the management of large colorectal lesions.
Future changes in the wintertime ENSO-NAO teleconnection under greenhouse warming
Authors: Kug Jong-Seong , Geng Xin , Kosaka Yu 
Published: December 2023

Abstract
El Niño-Southern Oscillation (ENSO) teleconnection to the Euro-Atlantic exhibits strong subseasonal variations, as the North Atlantic Oscillation (NAO) response systematically reverses its phase from early to late winter. Based on two sets of atmospheric model simulations in CMIP6 forced by historical and projected SST, we report a future disappearance of this teleconnection reversal, with the positive early winter ENSO-NAO correlation turning negative and the negative late winter correlation becoming stronger. We suggest that this negative NAO tendency is associated with the strengthening and eastward shift of the ENSO atmospheric teleconnection towards the Euro-Atlantic due to parallel changes in the ENSO tropical convection. While the early winter NAO phase transition is further facilitated by the mean state change in the North Atlantic jet meridional shear, which shifts the ENSO-driven Rossby wave-propagating direction, an intensified stratospheric pathway is demonstrated to play an additional role in strengthening the late winter NAO response.
Risk of developing hyperkalemia in patients with hypertension treated with combination antihypertensive therapy – a retrospective register-based study
Authors: Moussa Fatme , Al-Janabi Fatma Luai Mahdi , Taleb Sarah , Leutscher Peter , Kragholm Kristian , Krogager Maria , Kristiansen Dorte , Torp-Pedersen Christian , Søndergaard Marc , Søgaard Peter 
Published: December 2023

Abstract

Background The risk of hyperkalemia in relation to different combinations of antihypertensive therapy remains to be elucidated.Methods In this Danish register-based study, we aimed to investigate the risk of developing hyperkalemia in relation to different combinations of antihypertensive therapy. Using incidence density matching, we matched a hyperkalemic patient to five normokalemic patients on renal function, age, sex, and time between study entry and date of potassium measurement. Combination therapies were subdivided into eight groups: beta blockers (BB) + calcium channel blockers (CCB), BB + renin angiotensin system inhibitors (RASi), BB + RASi + mineralocorticoid receptor antagonists (MRA), CCB + RASi, CCB + RASi + thiazides, CCB + thiazides, RASi + thiazides, and other combinations. Multivariable conditional logistic regression was used to estimate the odds of hyperkalemia within 90 days for each of the eight antihypertensive combination therapies.Results A total of 793 patients with hyperkalemia were matched to 3,788 normokalemic patients. In multivariable analysis, odds of developing hyperkalemia when being treated with BB + RASi + MRA was 2.58 (95% CI, 1.87–3.56) compared to RASi + thiazides (reference). Another significant association with other combinations that indicated a strong association with increased hyperkalemia was seen for the BB + RASi combination (OR, 1.55 [95% CI, 1.21-2.00]). Combinations including CCB + RASi (OR, 1.00 [95% CI, 0.76–1.32]) and CCB + RASi + thiazides (OR, 0.85 [95% CI, 0.54–1.34]) were not significantly associated with hyperkalemia.Conclusion Combinations of BB + RASi, with and without MRA were significantly associated with an increased risk of developing hyperkalemia within 90 days of initiating treatment.
Actinobacillus pleuropneumoniae infection activates IL-1β expression in porcine alveolar macrophage by promoting β-amyloid production
Authors: Bei Weicheng , Yan Kang , He Qiyun , Tang Jia , Peng wei , Dou Beibei , Chen Huanchun 
Published: December 2023

Abstract
Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is a porcine respiratory tract pathogen and causes porcine pleuropneumonia. Porcine alveolar macrophage plays an important role during A. pleuropneumoniae infection. Amyloid precursor protein (APP) can be cleaved by β- and γ-secretase to produce β-amyloid (Aβ). APP and Aβ are related with inflammatory response. They activate micriglia and astrocyte to secrete IL-1β, IL-6 and other cytokines. In present study, we find that during interaction of A. pleuropneumoniae and porcine alveolar macrophage, two component system CpxAR upregulates wecA expression to increase lipopolysaccharide production, lipopolysaccharide promotes amyloid precursor protein (APP) production and cleavage to generate Aβ; the Aβ activates NF-κB leading to increased IL-1β expression. We present a hypothesis about A. pleuropneumoniae infection porcine alveolar macrophage regulates APP production and cleavage to control the quantity of Aβ; different quantities of Aβ induce PAMs produce different quantities of cytokines and leading to different pathological process of porcine pleuropneumonia.
Nano-indentation study of dislocation evolution in GaN-based Laser Diodes
Authors: Chen Jingjing , Su Xujun , Wang Guobing , Niu Mutong , Li Xinran , Xu Ke 
Published: December 2023

Abstract
The slip systems and motion behavior of dislocations induced by nano-indentation technique in GaN-based LDs were investigated. Dislocations with burgers vector of b = 1/3 < 11\(\stackrel{-}{2}\)3> were introduced on either {11\(\stackrel{-}{2}\)2} <11\(\stackrel{-}{2}\)3>, or {1\(\stackrel{-}{1}\)01}<11\(\stackrel{-}{2}\)3> pyramidal slip systems in the upper p-GaN layer. Besides, {0001}<11\(\stackrel{-}{2}\)0> basal and {11\(\stackrel{-}{2}\)0}<0001 > cylindrical slip systems were also activated. The AlGaN/InGaN multi-layers in device can provide mismatch stresses to prevent dislocations from slipping through. It was observed that the density of dislocations induced by the indenter significantly decreased from the upper to the lower regions of the multi-layers. The a + c dislocations on pyramidal slip planes and the c dislocations on {11\(\stackrel{-}{2}\)0} planes were mostly blocked by the strained layers.
Monensin, virginiamycin and mineral trace and yeast combination on animal performance and carcass and meat characteristics of bulls finished in feedlot and fed high grain diet
Authors: Duarte Vanessa , Ribeiro Fabio Garcia , Matos Aylle Medeiros , Prado Rodolpho Martin do , Silva Luiz Fernando Costa e , Carvalho Venício Macedo , Ávila Vicente Alfonso Díaz , Cardoso Melina Aparecida Plastina , Prado Ivanor Nunes do 
Published: December 2023

Abstract

A combination of monensin, virginiamycin and minerals trace could have a synergistic effect on animal performance and meat characteristics of bulls finished in feedlot. This study was realized to evaluate the influence of monensin, virginiamycin, minerals trace and yeast combination on animal performance, feed efficiency, in situ digestibility, feeding behavior, and carcass and meat characteristics from bulls finished in feedlot fed high-grain diet. A total of 36 (European vs. Nellore) bulls at 24 ± 3.2 months of age and with a body weight (BW) of 385.5 ± 3.84 kg were used in a completely randomized design. The four experimental diets were: CONT – without additives; MONE – inclusion of 30 mg of monensin/kg of DM; MOVI – inclusion of 30 mg of monensin + 30 mg of virginiamycin/kg of DM; MOMY – inclusion of 30 mg of monensin/kg of DM + 3.0 g of mineral traces and yeast/100 kg of BW. Final body weight was higher (P < 0.05) for the bulls fed MOVI (558.7 kg) and MOMY (554.6 kg) diets, intermediate for bulls fed MONE (529.3 kg) diet, and lower for bulls fed CONT (514.6 kg) diet. Likewise, the average daily gain was higher (P < 0.01) for bulls fed MOVI and MOMY (2.02 kg/d), intermediate for bulls fed MONE (1.72 kg/d), diet and lower for bulls fed CONT (1.57 kg/d) diets. Dry matter intake and other nutrients were similar (P> 0.05) among treatments. However, feed conversion improved (P < 0.05) for bulls fed MOVI and MOMY diets. Animals fed MOVI and MOMY spent more time ruminating compared to animals fed CONT and MONE (P = 0.034) diets. The carcass weights, carcass dressing and backfat thickness were greater (P< 0.05) for the bulls fed MOVI and MOMY diets. In conclusion, the inclusion of monensin or a combination of monensin + virginiamycin or monensin + mineral trace and yeast resulted in higher animal performance and improved feed efficiency.
Effects of near-infrared photobiomodulation on local skin blood flow in healthy subjects
Authors: Riaz Misbah , Bösch Patrick Christian , Åm Marte Kierulf , Ellingsen Reinold , Hjelme Dag Roar , Carlsen Sven Magnus , Christiansen Sverre Christian 
Published: December 2023

Abstract
Photobiomodulation causes an immediate increase in local blood flow. This study aimed to investigate the effect of 890 nm NIR exposure on local skin blood flow in young and middle-aged healthy subjects. In this placebo-controlled clinical trial, 12 young and 12 middle-aged healthy subjects received either continuous or intermittent NIR exposure (890 nm, 5.1 mW /cm 2 , 4.6 J/cm 2 , and 35.9 J total energy) on the skin of the upper lateral arm. The continuous exposure experiment, used in young subjects only, applied 30 minutes of continuous NIR light (experiment 1). The intermittent exposure experiment, used in both age groups, applied NIR light through 10 cycles of 3 minutes NIR exposure and 2 minutes OFF (for recording blood flow), resulting in 50 minutes of total time. Laser Doppler flowmetry and thermal images were used to monitor local blood flow and skin temperature. In young subjects, continuous NIR exposure compared to placebo significantly increased blood flow for the first 20 minutes post-exposure. Further, in young and middle-aged subjects, intermittent exposure increased blood flow during the whole exposure period and 15 minutes post-exposure. In young subjects, blood flow after continuous NIR exposure was significantly higher than intermittent NIR exposure only for the first 10 minutes. For intermittent exposure comparison between the two age groups, the blood flow was significantly higher in middle-aged subjects. We conclude that NIR PBM increases local skin blood flow in young and middle-aged subjects. The mode of NIR irradiation and the subjects’ age influenced the local skin blood flow response.
Nano-Engineered Versatile Janus Natural-Skin with Sandwich Structure for Wearable All-Season Personal Thermal Management
Authors: Xie Long , Wang Xuechuan , Wei Chao , Sun Siwei , Liang Shuang , Bai Zhongxue , Zou Xiaoliang , Zhou Yi , Yue Ouyang , Liu Xinhua 
Published: December 2023

Abstract

Thermal management wearables have shown immense potential for various applications, such as bio-integrated electronics, multifunctional fabrics, thermoelectric devices, and clinical medicine. Given the complex and volatile external environmental conditions they may encounter, thermal management wearables should possess versatile and comprehensive auxiliary functions to enable cutting-edge advanced applications. In this study, we present a multifunctional nano-engineered Janus-type natural-skin (SHRC-skin), offering dual modes of solar heating and radiative cooling, along with additional capabilities such as flammability resistance, electromagnetic interference (EMI) shielding, and physiological signal monitoring achieved through the integration of traditional spray techniques and a phase conversion pathway, using natural-skin as a substrate, enabling year-round personal thermal management. The radiative cooling side of the SHRC-skin incorporates a CA/Mg11(HPO3)8(OH)6 composite coating with an irregular porous structure, while the solar heating side consists of multi-walled carbon nanotubes (MWCNT) with a rough structure. The radiative cooling layer of SHRC-skin exhibited a solar reflectance of ~ 90.13% and a mid-infrared emittance of ~ 87.6%, whereas the heating layer demonstrated a solar absorptance of ~ 89%. These attributes translated to excellent thermal management performance in outdoor-tests. Furthermore, SHRC-skin offers a range of additional wearable functionalities, including exceptional asymmetric wetting, flame retardancy, electrical conductivity, Joule heating, electromagnetic shielding, and physiological signal monitoring. This versatility significantly enhances SHRC-skin's adaptability to complex and diverse environments. In summary, the multifunctional SHRC-skin can seamlessly transition between cooling and heating modes without additional energy input. This innovation holds great promise for all-season wearable thermal management, co-friendly travel, and energy-efficient building furnishings and opens up new possibilities for the development of wearable materials across various scenarios.
Enhanced Cone-Beam Computed Tomography Imaging through Deep Learning Model Reconstruction: Noise Reduction and Image Quality Optimization in Dental Diagnostics
Authors: Kazimierczak Wojciech , Wajer Róża , Komisarek Oskar , Wajer Adrian , Kazimierczak Natalia , Janiszewska-Olszowska Joanna , Serafin Zbigniew 
Published: December 2023

Abstract

To assess the impact of a vendor-agnostic deep learning model (DLM) on image quality parameters and noise reduction in dental cone-beam computed tomography (CBCT) reconstructions. A retrospective study was conducted on CBCT scans of patients from a single center, using the inclusion criteria of standard radiation dose protocol images. Objective image quality was assessed through contrast-to-noise ratio (CNR) measurements. Subjective quality was evaluated by two experienced readers using a five-point scale. The inter-reader reliability and repeatability were calculated. Thirty-seven patients were included in the study. The CNR levels in DLM reconstructions were significantly higher than in native reconstructions, and the mean CNR in ROI1 − 3 in DLM images was 11.12 ± 9.29, while for native reconstructions, it was 8.42 ± 5.89 (p < 0.05). However, there were no significant differences in the mean signal and noise levels between the two reconstruction methods. Subjective image quality assessment showed no statistically significant differences between native and DLM reconstructions. The use of deep learning-based image reconstruction algorithms in CBCT imaging of the oral tissues can improve the image quality by enhancing the contrast-to-noise ratio. This study underscores the potential of DLMs in improving dental diagnostic imaging and calls for further research on their clinical impact.
Compact hyperspectral imaging of extreme-depth-of-field diffractive lenses based on spatial–spectral sparse deep learning
Authors: Wei Chaoyang , Niu Zhenqi , Lu Yuying , Wan Songlin , Shao Jian-Da , Pan Yitong 
Published: December 2023

Abstract
Thin and flat diffractive optical elements (DOEs) are significant in the field of integrated optics and provide a novel and optimal solution for hyperspectral imaging (HI) which is expected to be compact, snapshot, with large depth of field (DoF) and resolution. The tradeoff between spectral and spatial resolutions caused by the restricted DoF, limits the application scenarios for HI. To address this, based on the prior of spatial and spectral sparse, we propose a spatial–spectral achromatic (SSA) neural network to end-to-end optimize a broad-bandwidth system with a DOE to provide the support for snapshotly achromatic extreme-DoF HI. We experimentally show that our system can snapshotly capture achromatic, high-fidelity hyperspectral images with 25 spectral channels ranging from 420 nm to 660 nm, covering distances from 0.5 m to 5 m. The proposed system enables precise and dynamic reconstruction of spectra within an extreme DoF, a capability previously unattainable with compact computational spectral cameras. The precise reconstruction of spectra demonstrates the potential of the developed system in various applications, such as precision agriculture, food quality inspection, and object detection.
Quantile-based optimization under uncertainties for complex engineering structures using active learning basis-adaptive PC-Kriging model
Authors: Gong Yulian , Zhang Jianguo , Xu Dan , Huang Ying 
Published: December 2023

Abstract
The reliability-based design optimization (RBDO) of complex engineering structures considering uncertainty has problems of high-dimensional, highly nonlinear and time-consuming, which requires a significant amount of sampling simulation computation. In this paper, a basis-adaptive PC-Kriging surrogate model is proposed, in order to relieve the computational burden and enhance predictive accuracy of metamodel. The active learning basis-adaptive PC-Kriging model is combined with quantile-based RBDO framework. Finally, four engineering cases have been implemented, including a benchmark RBDO problem, two high dimensional explicit problems and a high dimensional implicit problem. Compared with SVM, Kriging and polynomial chaos expansion models, the results show that the proposed basis-adaptive PC-Kriging model is more robust and efficient for RBDO problems of complex engineering structures.
Abdominal compartment syndrome during intraoperative hyperthermic intraperitoneal chemotherapy following debulking surgery for colorectal cancer: a case report
Authors: Chiu Chen-Hsi , Lu Cheng-Wei , Lin Tzu-Yu , Chen Pei-Fu 
Published: December 2023

Abstract
Background
Colorectal cancer frequently leads to peritoneal metastasis and necessitates treatments, such as hyperthermic intraperitoneal chemotherapy (HIPEC). However, HIPEC may result in perioperative complications, some often overlooked, such as abdominal compartment syndrome.
Case presentation
A 52-year-old female with colorectal cancer and peritoneal metastasis underwent debulking surgery followed by HIPEC. Extensive tumour burden and a 9-hour surgery resulted in a blood loss of 3200 mL; 10 units of packed red blood cells were transfused. During HIPEC, a sudden increase in airway pressure and severe hypotension were noted. The abdomen was tensed, thus suggesting abdominal compartment syndrome, and prompting termination of HIPEC and drainage of the chemotherapeutic solution. Despite intravenous fluids and vasopressors, she experienced circulatory and respiratory collapse. Laparotomy sutures were promptly removed, which effectively alleviated the intra-abdominal hypertension and immediately restored the vital signs. An inadequately repaired diaphragm defect was identified and repaired. A chest tube was inserted for pneumothorax.
Conclusions
Abdominal compartment syndrome is a critical complication of HIPEC. It can mimic HIPEC’s physiological effects and result in adverse outcomes.
Age-associated myelin decompaction and CNPase expression differ in magnitude in the substantia nigra of MPTP-sensitive C57BL/6J mice and MPTP-resistant CD-1 mice
Authors: PL Abhilash , Bharti Upasna , Anand Lakshmi , Sagar B. K. Chandrasekhar , Alladi Phalguni Anand 
Published: December 2023

Abstract
Opposing phenomena of both oligodendrogliosis and oligodendroglial degeneration is reported in the striatum of MPTP-injected mice model of Parkinson’s disease (PD); reducing the clarity on their contribution to PD pathology. Furthermore, the role of oligodendroglia of substantia nigra pars compacta (SNpc), in pathogenesis and differential susceptibility to PD, is not known. In our earlier study, the MPTP-sensitive young C57BL/6J showed loss of 50-60% of SNpc neurons following MPTP, whereas the MPTP-resistant CD-1 showed a loss of 15-17%, suggesting better neuroprotection in the latter. We now investigate the effects of age and MPTP on oligodendroglial and myelin sheath ultrastructure, in SNpc, by electron microscopy as well as myelin-associated protein CNPase by semi-quantitative confocal microscopy and immunoblotting.
MPTP-induced mitochondrial shrinkage suggests toxicity to mitochondria and dilation of Golgi-complex saccules indicates protein packaging deficits, in the oligodendroglia of young C57BL/6J. Contrariwise in CD-1, presence of elongated mitochondria and multiple polyribosomes may suggest preserved ultrastructure. The organelles were affected at middle age in C57BL/6J but at old age in CD-1. The neuropil of SNpc in both strains harbored unmyelinated and lightly myelinated fibers. The enhanced density of myelin fibers following MPTP, suggests re-myelination of surviving neurons. MPTP aggravated myelin decompaction at middle age in C57BL/6J, but at old age in CD-1. Upregulation of CNPase in MPTP-injected middle-aged CD-1 suggests attempt at compensation. Thus, oligodendroglia of the MPTP-sensitive strain shows degenerative features, while those of MPTP-resistant strain show compensatory capabilities against neuroinflammatory milieu; till middle age. It is pertinent to reconsider oligodendroglial involvement in PD.
Vitamin B5 improves TANGO2 gene mutations associated defects
Authors: Li Hua , Xu Zheng , Guo Jing , Zhang Peiqi , dong Xiaoli , Zhao Liming 
Published: December 2023

Abstract
Background: Under-diagnosis is likely to be a problem in TANGO2-
related disease, and the treatment strategies of it is unknow.
Case presentation: We report a 7-year-old Chinese girl, who presented with epilepsy, developmental delay, neuroregression, and episodes of dyskinesia. In addition, she slipped into a coma four times after generalized tonic-clonic seizure. A trio whole exome sequencing revealed homozygous single nucleotide variants in TANGO2 gene. Eventually, after she started to have vitamin B5, the clinical signs and symptoms were significantly improved.
Conclusions: A trio whole exome sequencing may help clinician to early diagnosis TANGO2 gene mutations associated disorders, and vitamin B5 supplement may be useful to it.