bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding tau rhythms in EEG: An independent component analysis approach
Authors: Wisniewski Matthew G. , Joyner Chelsea N. , Zakrzewski Alexandria C. , Makeig Scott 
Published: January 2024

AbstractTau rhythms are largely defined by sound responsive alpha band (~8–13 Hz) oscillations generated largely within auditory areas of the superior temporal gyri. Studies of tau have mostly employed magnetoencephalography or intracranial recording because of tau's elusiveness in the electroencephalogram. Here, we demonstrate that independent component analysis (ICA) decomposition can be an effective way to identify tau sources and study tau source activities in EEG recordings. Subjects (N = 18) were passively exposed to complex acoustic stimuli while the EEG was recorded from 68 electrodes across the scalp. Subjects' data were split into 60 parallel processing pipelines entailing use of five levels of high‐pass filtering (passbands of 0.1, 0.5, 1, 2, and 4 Hz), three levels of low‐pass filtering (25, 50, and 100 Hz), and four different ICA algorithms (fastICA, infomax, adaptive mixture ICA [AMICA], and multi‐model AMICA [mAMICA]). Tau‐related independent component (IC) processes were identified from this data as being localized near the superior temporal gyri with a spectral peak in the 8–13 Hz alpha band. These “tau ICs” showed alpha suppression during sound presentations that was not seen for other commonly observed IC clusters with spectral peaks in the alpha range (e.g., those associated with somatomotor mu, and parietal or occipital alpha). The choice of analysis parameters impacted the likelihood of obtaining tau ICs from an ICA decomposition. Lower cutoff frequencies for high‐pass filtering resulted in significantly fewer subjects showing a tau IC than more aggressive high‐pass filtering. Decomposition using the fastICA algorithm performed the poorest in this regard, while mAMICA performed best. The best combination of filters and ICA model choice was able to identify at least one tau IC in the data of ~94% of the sample. Altogether, the data reveal close similarities between tau EEG IC dynamics and tau dynamics observed in MEG and intracranial data. Use of relatively aggressive high‐pass filters and mAMICA decomposition should allow researchers to identify and characterize tau rhythms in a majority of their subjects. We believe adopting the ICA decomposition approach to EEG analysis can increase the rate and range of discoveries related to auditory responsive tau rhythms.
Patterns and predictors of adolescent engagement in a mindfulness‐based social–emotional learning program
Authors: Roudebush McKenna , Murray Desiree W. , Netschytailo Hannah , Jensen Todd M. 
Published: January 2024

AbstractIntroductionAlthough mindfulness‐based interventions (MBIs) show promise for promoting positive youth development, little is known about student engagement in MBIs. Initial research presents mixed findings in MBI engagement related to participant characteristics, and there is a lack of research examining the influence of context on engagement, despite the critical role context plays in academic engagement. This study examines the contribution of student demographic characteristics and classroom context to MBI engagement.MethodsSurvey engagement data were collected at three time points from 106 ninth grade students (Mage = 14.17 years, 60.4% female, 44.2% Black, 24.8% Hispanic/Latino) who participated in the Be CALM program during the 2021–2022 school year. Latent growth curve modeling was used to examine trajectory of student engagement and assess student and classroom predictors of engagement.ResultsThere was no overall change in the trajectory of student engagement, although variability was observed across classes. Identifying as Hispanic/Latino was associated with lower engagement (β = −.25, p = .008), although this did not appear to be related to program experience. Peer connections predicted engagement at the end of the program (β = .39, p < .001). Post hoc analyses suggested that student engagement may be related to teacher program delivery quality.ConclusionsStudent engagement in MBIs appears related to classroom context more than student characteristics, although further research with larger samples is needed to assess the link between engagement and program outcomes. Findings have implications for designing school‐based MBIs and training school staff to deliver them in culturally responsive ways.
Theoretical study of the functional characteristics of composite fiber/colorant materials for military digital camouflage
Authors: Liu Chuan‐Wen , Peng Cheng‐Hsiung , Lin Chun‐Chih , Liu Min‐Hsien , Chen Cheng‐Lung 
Published: January 2024

AbstractBackgroundBased upon experimental literatures to simulate many newly developed systems and analyzed and compared the physical properties and NIR absorption of the materials for supplying future research reference into military camouflage clothing.AimsThis project aimed to explore composite fiber/cotton/colorant materials that possess the characteristic of anti‐near‐infrared radiation (NIR) reflectance and their further application in military combat uniforms to achieve the aim of personnel camouflage and concealment.Materials and MethodsMaterials Studio (MS06 version), Gaussian 09 software, and the GULP program were adopted for simulation and computation in this study.Results and DiscussionThe physical absorption of the dyes and nylon 66/cotton exhibited the same trend from large to small in the order NCIBu > NCD > NCIG > NCT > NCA. All systems had good colorfastness except for the NCA, NCD, and NCT systems. The colorfastness of the dual‐dye systems was better than that of the single‐dye systems; in particular, the colorfastness of the NCIG‐138T and NCIBu‐12D systems. The six layered NCT, NCIBu, NCIBu‐12D, NCIG‐138T systems exhibited excellent reflectivity in the NIR region.ConclusionsThe NCIBu‐12D and NCIBu‐138D systems, with a weight percentage of 2/49/49%, exhibited the best performance in our simulation. These achievements could be helpful in terms of informing actual experiments in order to perfect the design of military clothing.
Are enhanced recovery protocols after pancreatoduodenectomy still efficient when applied in elderly patients? A systematic review and individual patient data meta‐analysis
Authors: Kuemmerli Christoph , Balzano Gianpaolo , Bouwense Stefan A. , Braga Marco , Coolsen Mariëlle , Daniel Sara K. , Dervenis Christos , Falconi Massimo , Hwang Dae Wook , Kagedan Daniel J. , Kim Song Cheol , Lavu Harish , Nussbaum Daniel , Partelli Stefano , Passeri Michael J. , Pecorelli Nicolò , Pillarisetty Venu G. , Pucci Michael J. , Sutcliffe Robert P. , Tingstedt Bobby , van der Kolk Marion , Vrochides Dionisios , Armstrong Misha , Wei Alice , Williamsson Caroline , Yeo Charles J. , Zani Sabino , Zouros Efstratios , Rozzini Renzo , Abu Hilal Mohammed 
Published: January 2024

AbstractBackgroundThis meta‐analysis investigated the effects of enhanced recovery after surgery (ERAS) protocols compared to conventional care on postoperative outcomes in patients aged 70 years or older undergoing pancreatoduodenectomy (PD).MethodsFive databases were systematically searched. Comparative studies with available individual patient data (IPD) were included. The main outcomes were postoperative morbidity, length of stay, readmission and postoperative functional recovery elements. To assess an age‐dependent effect, the group was divided in septuagenarians (70–79 years) and older patients (≥80 years).ResultsIPD were obtained from 15 of 31 eligible studies comprising 1109 patients. The overall complication and major complication rates were comparable in both groups (OR 0.92 [95% CI: 0.65–1.29], p = .596 and OR 1.22 [95% CI: 0.61–2.46], p = .508). Length of hospital stay tended to be shorter in the ERAS group compared to the conventional care group (−0.14 days [95% CI: −0.29 to 0.01], p = .071) while readmission rates were comparable and the total length of stay including days in hospital after readmission tended to be shorter in the ERAS group (−0.28 days [95% CI: −0.62 to 0.05], p = .069). In the subgroups, the length of stay was shorter in octogenarians treated with ERAS (−0.36 days [95% CI: −0.71 to −0.004], p = .048). The readmission rate increased slightly but not significantly while the total length of stay was not longer in the ERAS group.ConclusionERAS in the elderly is safe and its benefits are preserved in the care of even in patients older than 80 years. Standardized care protocol should be encouraged in all pancreatic centers.
Neutralizing antibody response after immunization with a COVID‐19 bivalent vaccine: Insights to the future
Authors: Souza Milena Silva , Farias Jéssica Pires , Andreata‐Santos Robert , Silva Marianne Pereira , Brito Ruth Dálety da Silva , Duarte Barbosa da Silva Marcia , Peter Cristina Mendes , Cirilo Marcus Vinícius de França , Luiz Wilson Barros , Birbrair Alexander , Vidal Paloma Oliveira , de Castro‐Amarante Maria Fernanda , Candido Erika Donizetti , Munhoz Aldilene Silva , de Mello Malta Fernanda , Dorlass Erik Gustavo , Machado Rafael Rahal Guaragna , Pinho João Renato Rebello , Oliveira Danielle Bruna Leal , Durigon Edison Luiz , Maricato Juliana Terzi , Braconi Carla Torres , Ferreira Luís Carlos de Souza , Janini Luiz Mário Ramos , Amorim Jaime Henrique 
Published: January 2024

AbstractThe raising of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants led to the use of COVID‐19 bivalent vaccines, which include antigens of the wild‐type (WT) virus, and of the Omicron strain. In this study, we aimed to evaluate the impact of bivalent vaccination on the neutralizing antibody (NAb) response. We enrolled 93 volunteers who had received three or four doses of monovalent vaccines based on the original virus (n = 61), or a booster shot with the bivalent vaccine (n = 32). Serum samples collected from volunteers were subjected to neutralization assays using the WT SARS‐CoV‐2, and Omicron subvariants. In addition, immunoinformatics to quantify and localize highly conserved NAb epitopes were performed. As main result, we observed that the neutralization titers of samples from individuals vaccinated with the bivalent vaccine were higher for the original virus, in comparison to their capacity of neutralizing the Omicron variant and its subvariants. NAb that recognize epitopes mostly conserved in the WT SARS‐CoV‐2 were boosted, while those that recognize epitopes mostly present in the Omicron variant, and subvariants were primed. These results indicate that formulation of future vaccines shall consider to target present viruses, and not viruses that no longer circulate.
Endoscopist experience with pediatric recurrent and intentional foreign body ingestion (RIFBI): Management considerations and future directions
Authors: Low Kapalu Christina M. , Uraizee Omar , Lerner Diana G. , Thomson Mike , Attard Thomas 
Published: January 2024

AbstractObjectives and StudyAccidental foreign body ingestion (FBI) is a common pediatric referral concern. In contrast, recurrent and intentional FBI (RIFBI) is infrequent and associated with greater endoscopic and surgical intervention in adults. Although pediatric guidelines exist for FBI, the risk and therapeutic implications of RIFBI are not addressed. An anonymous international survey on pediatric gastroenterologist experience with RIFBI was distributed.MethodsA 33‐item REDCap© survey was distributed via email to pediatric gastroenterologists identified through mailing and email lists obtained from pediatric gastroenterology professional organizations.ResultsDuring 9−12/2021 we accrued 202 completed surveys. Respondents were from 27 countries and across the career span. Eighty percent reported experience with RIFBI; 74% reported seeing ≤ 3 patients with RIFBI within the past 24 months and 4% reported seeing ≥ 6. Of those who treated RIFBI, 38% reported an average number of annual ingestions per patient was ≥5. Frequent morbidity but not mortality was reported.Half reported adherence to FBI guidelines. Later‐career endoscopists treated RIFBI more aggressively than accidental ingestion. Ninety‐six percent noted that patients with RIFBI had psychiatric comorbidities. Providers at academic medical centers reported referring to behavioral health more than those in other settings.ConclusionMost gastroenterologists surveyed reported encountering RFBI several times a year and in patients with psychiatric comorbidities. Greater likelihood of adverse outcomes associated with endoscopy was reported. Most reported referral to behavioral health and few had RIFBI management protocols. A broader spectrum of psychologic comorbidities in the pediatric population with RIFBI, notably depression and autism spectrum disorder, were reported.
First reported fossil occurrences of Phrynosoma sp. from the Columbia Plateau (Washington State, USA) dated to the Late Pleistocene
Authors: Richter Audra J. , Pickles Brian J. , Barton Bax R. 
Published: January 2024

ABSTRACTReptiles, squamates in particular, can be extremely valuable as indicator species due to their commonly small fundamental niche ranges. Yet these taxa are often overlooked in North American Cenozoic palaeoecological studies in favour of mammalian specimens. At the Coyote Canyon Mammoth Site (CCMS) on the Columbia Plateau (eastern Washington State, USA) excavation has focused on the collection and subsequent identification of all diagnostic fossil specimens, whether associated directly with the mammoth remains or not, including small non‐mammalian vertebrates and invertebrates. Here we show that with appropriate excavation techniques, microvertebrate fossils are recoverable and can be identified to at least the genus level. We place the identification of two fossils of Phrynosoma at the CCMS, dated to ~13 and 15 ka, in the context of all recorded fossils identified to this genus in North America since the Middle Miocene. These specimens represent the first fossils of Phrynosoma adequately described and reported from the Columbia Plateau and the greater Pacific Northwest.
Effect of different gelators on the physicochemical properties and microstructure of coconut oleogels
Authors: Yang Zihan , Cui Jingtao , Yun Yonghuan , Xu Yongjiang , Tan Chin‐Ping , Zhang Weimin 
Published: January 2024

AbstractBACKGROUNDThe inherent properties of coconut oil (CO), including its elevated saturated fatty acid content and low melting point, make it suitable for application in plastic fat processing. The present study explores the physicochemical characteristics, micromorphology and oxidative stability of oleogels produced from CO using various gelators [ethylcellulose (EC), β‐sitosterol/γ‐oryzanol (PS) and glyceryl monostearate (MG)] to elucidate the formation mechanisms of coconut oleogels (EC‐COO, PS‐COO and MG‐COO).RESULTSThree oleogel systems exhibited a solid‐like behavior, with the formation of crystalline forms dominated by β and β′. Among them, PS‐COO exhibited enhanced capability with respect to immobilizing liquid oils, resulting in solidification with high oil‐binding capacity, moderate hardness and good elasticity. By contrast, MG‐COO demonstrated inferior stability compared to PS‐COO and EC‐COO. Furthermore, MG‐COO and PS‐COO demonstrated antioxidant properties against CO oxidation, whereas EC‐COO exhibited the opposite effect. PS‐COO and EC‐COO exhibited superior thermodynamic behavior compared to MG‐COO.CONCLUSIONThree oleogels based on CO were successfully prepared. The mechanical strength, storage modulus and thermodynamic stability of the CO oleogel exhibited concentration dependence with increasing gelling agent addition. PS‐COO demonstrated relatively robust oil‐binding capacity and oxidative stability, particularly with a 15% PS addition. This information contributes to a deeper understanding of CO‐based oleogels and offers theoretical insights for their application in food products. © 2024 Society of Chemical Industry.
Paradoxical granulomatous reaction to ustekinumab
Authors: Obijiofor Chinemelum , Mazori Daniel R. , Femia Alisa N. , Flamm Alexandra , Caplan Avrom S. 
Published: January 2024

AbstractSarcoidosis is a multisystem disorder characterised by granulomatous inflammation affecting various organs. The skin is commonly involved and can serve as an initial indicator of disease. While the precise aetiology of sarcoidosis remains elusive, evidence suggests involvement of T‐helper type (TH)‐1 and TH‐17 pathways. Psoriasis shares common inflammatory pathways with sarcoidosis, prompting the repurposing of biologic therapies approved for psoriasis for off‐label treatment of cutaneous sarcoidosis. However, this approach has raised concerns due to the development of granulomatous eruptions in some patients. We present a case of a patient with psoriasis who was diagnosed with systemic sarcoidosis while on ustekinumab. We review previous cases of ustekinumab‐associated sarcoidosis and discuss the challenges associated with utilising biologic agents originally intended for psoriasis treatment for sarcoidosis.
Ab initio kinetic study on the abstraction reactions of methylcyclohexane and implications for high‐temperature ignition simulations from shock tube experiment
Authors: Liang Jinhu , Jia Ming‐Xu , Yao Qian , Kang Guo‐Jun , Zhang Yang , Zhao Fengqi , Wang Quan‐De 
Published: January 2024

AbstractMethylcyclohexane (MCH) is the simplest alkylated cyclohexane, and has been widely employed in surrogate models to represent the cycloalkanes in real fuels. Thus, extensive experimental and kinetic modeling studies have been performed to understanding the combustion chemistry of MCH. However, through a detailed literature analysis, there still lack a systematic theoretical study on the abstraction reactions of MCH, which are the main initial oxidation pathway of MCH. Herein, this work reports a systematic ab initio chemical kinetic study on the abstraction reactions of MCH with different radicals/species. Specifically, reaction rate constants of 30 abstraction reactions of MCH with H/O/OH/O2/HO2/CH3 at different sites are computed using transition state theory (TST) by using quantum chemistry calculation results at DLPNO‐CCSD(T)/CBS//M06‐2X/cc‐pVTZ level. The computed results are incorporated into a detailed mechanism to simulate newly measured ignition delay times (IDTs) of MCH in this work at equivalence ratios of 0.5, 1.0, and 2.0, pressures of 2 and 5 bar, temperatures ranging from 1140 to 1640 K. The updated detailed mechanism demonstrates improvement in the prediction of IDTs, especially at fuel‐rich conditions. The fuel concentration and dilution effect on the IDTs are discussed, and a general Arrhenius expression is adopted to fit the IDTs from both this work and literature work. This work should be valuable for further optimization of detailed kinetic mechanisms and also for gaining insight into the combustion chemistry of MCH.
Improvement in functional outcome 1 year after nonsurgical multidisciplinary treatment for chronic pain after total knee arthroplasty: A prospective cohort study
Authors: Hoevenaars Evelien H. W. , Smolders José M. H. , Veenstra Kirsten , O'Dowd John , Heesterbeek Petra J. C. 
Published: January 2024

AbstractPurposeThe purpose of this study was to evaluate a multidisciplinary intervention developed for patients with debilitating chronic pain after total knee arthroplasty (TKA) unresponsive to existing treatment options.MethodsA treatment‐based prospective cohort study was caried out in 30 TKA patients with debilitating chronic pain at least 1 year after TKA. The treatment was a multidisciplinary intervention. Main inclusion criteria: no indication for surgery. Primary outcome was function measured by KOOS‐PS, OKS, OKS‐APQ and WORQ. Secondary outcome measures were pain, fear of movement, self‐efficacy, quality of life (QoL), health care and pain medication use, work rehabilitation and patient satisfaction. The assessments took place pre‐ and directly posttreatment, at 1, 3 and 12 months follow‐up. The clinical relevance was assessed by predefined minimal important clinical change (MCIC).ResultsAt baseline patients were on average 64.7 (±7.9) years old, 67% were female, and they had knee pain for 42 (10–360) months. The results at 12‐month follow‐up: first, a significant improvement was shown in function, pain, fear of movement, self‐efficacy and QoL. Second, in 38.5%–69.2% of patients clinical relevant improvement was shown for functional outcome, 31% for pain, and 50% for self‐efficacy. Third, 42% of patients reported ‘no healthcare use in the past three months’.ConclusionOne year after a multidisciplinary treatment a clinically relevant improvement was shown in terms of function, pain, self‐efficacy and QoL. It seems to be a promising treatment option in this difficult‐to‐treat patient group with debilitating chronic pain after TKA. Future research should examine the effect of the treatment in a larger study population, considering a control group, and focusing on the working population and evaluating cost‐efficacy.Level of EvidenceLevel II.
Anti‐Inflammatory Effect of Dental Pulpa Mesenchymal Stem Cell Exosomes Loaded Mucoadhesive Hydrogel on Mice with Dental Nickel Hypersensitivity
Authors: Eren Belgin Ezgi , Genç Deniz , Tekin Leyla , Sezgin Serhat , Aladağ Akın 
Published: January 2024

AbstractIn this study, the anti‐inflammatory effect of dental pulp mesenchymal stem cell (MSCs) exosomes loaded to mucoadhesive hydrogel is investigated in a dental nickel hypersensitivity murine model. After culture of dental pulp MSCs in the third passage MSCs are loaded to a mucoadhesive hydrogel based on chitosan, cross‐linked with genipin and modified with catechol groups. A dental nickel hypersensitivity model is created by administering NiCl2 and 10 µg mL−1 lipopolysaccharide to 4–6 week‐old Balb‐c mice by intradermal injection. In mice treated with dental pulp MSC exosomes and exosomes in hydrogel, interferron gamma (IFN‐γ) secreting CD4+T lymphocyte ratios significantly increase compared to the untreated group (p < 0.05). IFN‐γ and interleukin 10 (IL‐10) expression in buccal mucosa tissue sections and IFN‐γ secreting CD4+T lymphocyte ratios are found to be significantly higher in mice treated with dental pulpa MSCs (DPMSCs) exosomes and DPMSCs exosomes in hydrogel compared to the untreated group (p < 0.05). According to flow cytometry results, IL‐4 secreting CD4+T lymphocytes are found to be significantly decreased in DPMSCs exosomes group compared to dental nickel hypersensitivity group (p < 0.05). Administration of DPMSCs exosomes with mucoadhesive hydrogel may be an alternative to current medication in the treatment of dental nickel hypersensitivity.