bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR-100-5p transfected MSCs-derived exosomes can suppress NSCLC progression via PI3K-AKT-mTOR
Authors: Wei Jing , Chen Tianyu , Feng Ganzhu 
Published: October 2023

Abstract

Objectives
Exosomes are highly implicated in lung cancer and are capable of transferring therapeutic miRNAs.

Methods
Database analysis was performed to screen the probable miRNA involved in non-small cell lung cancer (NSCLC). The levels of miR-100-5p in NSCLC cells and tissues were evaluated. The mechanism by which MSC-derived exosomes mediate the delivery of miR-100-5p in NSCLC cells was explored in vitro. The therapeutic effect and safety of miR-100-5p-containing MSC-derived exosomes in nude mice were assessed.

Results
MiR-100-5p was significantly downregulated in NSCLC. Transfer of miR-100-5p via MSCs-derived exosomes inhibited NSCLC progression by the PI3K-AKT-mTOR pathway. No obvious toxic effects were observed in mice.

Conclusions
MSCs-derived exosome-transfected miR-100-5p inhibits NSCLC progression via PI3K-AKT-mTOR, providing a promising diagnostic biomarker and therapeutic target of NSCLC.
TÜRKİYE’NİN VE SEBZE SEKTÖRÜNDE SÖZ SAHİBİ ÜLKELERİN İHRACAT REKABET GÜÇLERİNİN KARŞILAŞTIRMALI ANALİZİ
Authors: YALÇIN Mahsun 
Published: October 2023

Öz
Bu çalışmanın amacı, Türkiye’nin ve sebze ihracatında en fazla paya sahip ülkelerin (ABD, Hollanda, İspanya, Çin) sebze sektörü ihracat rekabet uzmanlaşma düzeyini tespit edip karşılaştırmalı perspektiften analiz etmektir. Bu doğrultuda çalışmada, söz konusu ülkelerin 2012-2021 dönemi ihracat ve ithalat değerleri, WITS veri tabanından alınmıştır. Analizler, SITC Rev. 3 gruplandırmasına ait “05- Meyve ve sebzeler” ürün grubu kapsamındaki 5 sebze alt ürün grubu için Açıklanmış Karşılaştırmalı Üstünlükler (AKÜ) metodu kullanılarak yapılmıştır. Net İhracat İndeksi sonucuna göre, Çin ve Hollanda’nın sebze ürün gruplarının tümünün ihracatında uzmanlaştığı (rekabet avantajı elde ettiği) tespit edilmiştir. Balassa İndeksi sonuçları, Hollanda’nın 3, geriye kalan ülkelerin ise 2 sebze ürün grubunda rekabet avantajı elde ettiğini göstermektedir. İhracat Benzerlik İndeksi sonucuna göre, Türkiye ile en fazla rekabet içerisinde olan ülkelerin İspanya ve Çin olduğu belirlenmiştir. Ayrıca, Türkiye’nin emek ve sermaye yoğun, ABD’nin hammadde yoğun ve zor taklit, Hollanda’nın hammadde yoğun ve kolay taklit, İspanya’nın hammadde, emek ve sermaye yoğun, Çin’in ise emek yoğun ve kolay taklit malların ihracatında uzmanlaşma gösterdiği tespit edilmiştir.
Anahtar Kelime: Sebze ihracatı, Uzmanlaşma, RCA, Balassa indeksi
Plasticity in Preganglionic and Postganglionic Neurons of the Sympathetic Nervous System during Embryonic Development
Authors: Ratliff April , Pekala Dobromila , Wenner Peter 
Published: October 2023

AbstractSympathetic preganglionic neurons (SPNs) are the final output neurons from the central arm of the autonomic nervous system. Therefore, SPNs represent a crucial component of the sympathetic nervous system for integrating several inputs before driving the postganglionic neurons (PGNs) in the periphery to control end organ function. The mechanisms which establish and regulate baseline sympathetic tone and overall excitability of SPNs and PGNs are poorly understood. The SPNs are also known as the autonomic motoneurons (MNs) as they arise from the same progenitor line as somatic MNs that innervate skeletal muscles. Previously our group has identified a rich repertoire of homeostatic plasticity (HP) mechanisms in somatic MNs of the embryonic chick followingin vivosynaptic blockade. Here, using the same model system, we examined whether SPNs exhibit similar homeostatic capabilities to that of somatic MNs. Indeed, we found that after 2-d reduction of excitatory synaptic input, SPNs showed a significant increase in intracellular chloride levels, the mechanism underlying GABAergic synaptic scaling in this system. This form of HP could therefore play a role in the early establishment of a setpoint of excitability in this part of the sympathetic nervous system. Next, we asked whether homeostatic mechanisms are expressed in the synaptic targets of SPNs, the PGNs. In this case we blocked synaptic input to PGNsin vivo(48-h treatment), or acutelyex vivo, however neither treatment induced homeostatic adjustments in PGN excitability. We discuss differences in the homeostatic capacity between the central and peripheral component of the sympathetic nervous system.
Different Methods to Estimate the Phase of Neural Rhythms Agree But Only During Times of Low Uncertainty
Authors: Wodeyar Anirudh , Marshall François A. , Chu Catherine J. , Eden Uri T. , Kramer Mark A. 
Published: October 2023

AbstractRhythms are a common feature of brain activity. Across different types of rhythms, the phase has been proposed to have functional consequences, thus requiring its accurate specification from noisy data. Phase is conventionally specified using techniques that presume a frequency band-limited rhythm. However, in practice, observed brain rhythms are typically nonsinusoidal and amplitude modulated. How these features impact methods to estimate phase remains unclear. To address this, we consider three phase estimation methods, each with different underlying assumptions about the rhythm. We apply these methods to rhythms simulated with different generative mechanisms and demonstrate inconsistency in phase estimates across the different methods. We propose two improvements to the practice of phase estimation: (1) estimating confidence in the phase estimate, and (2) examining the consistency of phase estimates between two (or more) methods.
The Role of Ownership Structure in Moderating The Relationship Between Tax Avoidance, Corporate Social Responsibility Disclosure, and Firm Value
Authors: Ardillah Kenny , Breliastiti Ririn , Setiawan Temy , Machdar Nera Marinda 
Published: October 2023

Purpose: The company’s existence can be maintained by increasing the firms value every period, which will affect the welfare of investors. This study aims to examine and analyze the effect of tax avoidance, corporate social responsibility disclosure on firm value with managerial ownership as a moderating variable.
Method: This study uses a sample of mining companies listed on the Indonesia Stock Exchange for 2016-2019. In this study, tax avoidance uses the Effective Tax Rate proxy, and corporate social responsibility disclosure uses the Corporate Social Responsibility Index. Firm value is measured using Tobin’s Q, and ownership structure as a moderating variable is measured by managerial and institutional ownership proxies.
Findings: The results showed that tax avoidance and corporate social responsibility disclosure had no effect on firm value with firm size and capital intensity as control variables. Managerial ownership and institutional ownership significantly impact the relationship between tax avoidance and firm value with firm size and capital intensity as control variables. Managerial ownership and institutional ownership have no significant effect in moderating the relationship between corporate social responsibility disclosure and firm value with firm size and capital intensity as control variables.
Novelty: The research used institutional ownership and managerial ownership as part of ownership structures to moderate the relationship between tax avoidance, corporate social responsibility disclosure, and firm value.
Keywords: Tax Avoidance; Corporate Social Responsibility Disclosure; Firm Value; Ownership Structure; Managerial Ownership; Institutional Ownership
The Moderating Effect of Abusive Supervision on Religiosity and Whistleblowing Relationship: An Experimental Investigation
Authors: Jannah Khusnul , Rohma Frida Fanani , Faisol Imam Agus 
Published: October 2023

Purpose: This study examines the causal relationship between religiosity on whistleblowing. Besides, this study also identifies the moderating role of abusive supervision on the relationship between those two variables.
Method: This study used a 2 × 2 between-subjects laboratory experiment with accounting undergraduate students as the subjects. The religiosity is categorized into two levels (high and low). The variable of abusive supervision is manipulated into two levels (high and low).
Findings: High religiosity increase whistleblowing. Also, abusive supervision negatively influences whistleblowing. However, abusive supervision moderates the causal relationship between religiosity and whistleblowing. The study demonstrates the significant impact of abusive supervision on an unwillingness to blow the whistle, although the individual is embedded in religious values.
Novelty: This study fills a gap in the literature by showing that the tune of the top with a higher hierarchical structure can make an individual's values mingle with the organizational environment and impact his decision to blow the whistle. Furthermore, this research contributes to the conservation of resource theory by providing evidence that superiors have an essential role in molding the behavior of human resources in organizations.
Keywords: Abusive Supervision, Decision-Making, Religiosity, Whistleblowing
Experimental evaluation of analgesic activity of Naga Parpam: An Siddha formulation
Authors: V Shalini , A Mariappan , G Senthilvel , R Meenakumari 
Published: October 2023

Background : Prolonged usage of NSAIDs and corticosteroids was associated with serious side effects. Siddha is an ancient system of medicine, promotes the utilization of herbal anad elemental formulations. Interestingly, certain elements considered toxic in modern medicine, such as Arsenic (As), Cadmium (Cd), Mercury (Hg), Iron (Fe), Silver (Ag), Gold (Au), etc., have been employed in Siddha herbo mineral formulation for the treatment of illness, a practice that dates back to ancient times. Introduction Pain is a widely recognized indicator of poor health, the analgesic medications are employed to alleviate it. In Siddha classics, pain is considered a separate disease called Soolai. Naga Parpam is one of the herbo metal preparations with analgesic potential but no scientific evaluation there. Aim: To evaluate the analgesic activity of Naga parpam in experimental rats using Tail immersion method. Materials and methods : After obtaining permission from the IAEC, the animals were separated into 5 groups of 6 animals Each Group 1 (control) received ghee orally, and Group 2 (standard) received Pentazocine in dose 10 mg/kg intraperitoneally. The test drug Naga parpam was mixed with the adjuvant Ghee and administrated per oral route to three groups (Group 3,4,5), Group 3 (test) received Naga Parpam in low dose 6 mg/kg, Group 4 (test) received mid dose 12 mg/kg, Group 5 (test) received high dose – 24 mg/kg ). Statistical analysis : One-way ANOVA followed by the Dunnett test P < 0.05 was considered to be significant. Results : The test drug Naga parpam has significant analgesic activity in the tail flick method (P <0.01) by increasing the reaction time of the rats. Conclusion : The present study indicates that the test drug Naga parpam possesses significant central analgesic activity in the tail flick method.
Development of Adolescent Well-Being Model in Malaysia: Analysis of Protective Factors in School
Authors: Bakar Azlina Abu , Mohamad Haslina , Kasim Tengku Sarina Aini Tengku , Selamat Taufiqnur , Hassan Anuar Abu , Bakar Noor Insyiraah Abu , Thurasingam Vignes , Nordin Mohammad Hazim Amir 
Published: October 2023

Well-being is a multidimensional construct that involves a state where individuals find peace, life needs are met, have a meaningful life, have life goals, autonomy, have a satisfactory quality of life in terms of physical, psychological and social. The partial least squares structural equation modelling (PLS-SEM) was employed to assess the research model using SmartPLS 4. This study was conducted on 587 teenagers. Among other factors measured in this study are resilience, relationship with school, parental involvement, self-efficacy, religiosity and spirituality. Among the instruments used in this study are Well-Being Scale, Spiritual Well-being, Religiosity Scale, Resiliency Belief Scale, Coppell's Self-Efficacy Scale, Parental Involvement Questionnaire and School Attachment Questionnaire. The items in this instrument are hypothesized as a priori and have non-zero loading for all dimensions in the model. The analysis of the items shows that the measurement model for all instruments is a well-fitting, multidimensional and reflective model. Data is also free of multicollinearity with good internal validity, convergent and discriminant validity. The results also demonstrate that resilience, school attachment, religiosity, parental involvement, self-efficacy altogether positively affected teenagers’ well-being (? = 0.158, ? = 0.193, ? = 0.154, 0.280, 0.345,p <0.01) respectively, except spirituality. The model explained 68 percent of the variance in well-being (R2=. 675) with AVE 0.70 and composite reliability 0.97. Analysis of the items resulted in a well-fitting model (SRMR<0.08, p<0.01). Therefore, well-being of young generation is significant to bring sustainable development to the mainstream and as protective factors against some of the challenges that may arise so that they have ability for self-regulation in emotions and become resilience. The promotion of well-being in teens can help mitigate the onset of negative effects of mental health.
Rendimiento, características morfológicas y calidad del chile dulce (Capsicum annuum L.) bajo dos densidades de siembra y tipos de podas
Authors: Carrillo-Montoya Kevin , Vargas-Rojas Jorge Claudio 
Published: October 2023

Introducción. El chile dulce tipo Bell es uno de los vegetales de mayor consumo, sin embargo, en las zonas de clima cálido se necesita más investigación en prácticas de manejo agronómico para aumentar la producción y calidad de fruta. Objetivo. Evaluar el efecto de dos densidades de siembra y dos tipos de poda sobre el rendimiento, características morfológicas y calidad de frutos del chile dulce tipo Bell. Materiales y métodos. La investigación se realizó en un invernadero en Guanacaste, Costa Rica, entre julio de 2015 a marzo de 2016. Se evaluaron dos densidades de siembra: 20 800 y 41 700 plantas/ha, y dos sistemas de poda (holandesa y española), más un testigo sin poda. Se cuantificó el peso de frutos, los grados brix, la altura de planta, el índice de área foliar, el rendimiento total y por categoría de calidad. Los datos obtenidos de cada variable se estudiaron con un análisis de varianza con estructura factorial de tratamientos. Resultados. La poda no afectó el rendimiento de primera calidad, mientras que la densidad de siembra más alta logró un mayor rendimiento en esta categoría. La poda española generó frutos de mayor longitud de primera calidad, pero no tuvo efecto sobre las demás variables (ancho, peso y grados brix). Al utilizar cualquier sistema de poda y una alta densidad de siembra, se obtuvo el mismo rendimiento total (p>0,05) que las plantas sin poda sembradas en baja densidad. Conclusión. El aumento de la densidad de siembra incrementó el rendimiento de frutos de primera calidad, mientras que la poda no tuvo efecto en el rendimiento.
The reality of professional education teachers in Jordan's use of modern learning strategies
Authors: AL-Momani Mohammad Omar , Rababa Elham Mahmoud 
Published: October 2023

The information revolution created today has created increased information and various learning resources. The existence of these developments causes teachers to need to re-identify how modern learning strategies and the application of teaching methods are primarily for teachers in vocational schools. This study was conducted to identify the reality of using modern learning strategies in teaching vocational education at the basic stage from the point of view of vocational education teachers in Jordan, where a descriptive analytical approach is used, and to achieve the objectives of the study and answers. In this study the method used is descriptive analytical method using a questionnaire as an instrument for research. Questionnaires were distributed online to research respondents who are teachers who teach in vocational schools. The results of the study found that the use of modern strategies in the educational process has a positive impact on students, in addition to the statistically significant differences between teachers who use modern learning strategies in teaching compared to teachers who apply traditional teaching methods. For further research, the authors recommend managing learning materials to facilitate and improve the implementation of active learning strategies. AbstrakRevolusi informasi yang tercipta pada zaman sekarang menciptakan meningkatnya informasi dan berbagai sumber belajar. Adanya perkembangan tersebut menyebabkan guru perlu untuk mengidentifikasi kembali bagaimana strategi pembelajaran modern dan penerapan metode ajar utamanya untuk guru pada sekolah kejuruan. Penelitian ini dilakukan untuk mengidentifikasi realitas penggunaan strategi pembelajaran modern dalam mengajar pendidikan kejuruan pada tahap dasar dari sudut pandang guru pendidikan kejuruan di Yordania, di mana pendekatan deskriptif analitis digunakan, dan untuk mencapai tujuan studi dan jawaban. Dalam penelitian ini metode yang digunakan adalah metode deskriptif analitik dengan menggunakan kuesioner sebagai instrumen untuk penelitian. Kuesioner disebarkan secara daring kepada responden penelitian yang merupakan guru yang mengajar di sekolah kejuruan. Hasil penelitian menemukan bahwa penggunaan strategi modern dalam proses pendidikan memberikan dampak positif bagi siswa, selain adanya perbedaan yang signifikan secara statistik antara guru yang menggunakan strategi pembelajaran modern dalam mengajar dibandingkan dengan guru yang menerapkan metode pengajaran tradisional. Untuk penelitian selanjutnya, penulis merekomendasikan untuk melakukan pengelolaan materi pembelajaran untuk mempermudah dan meningkatkan implementasi strategi pembelajaran aktif..Kata Kunci: Guru pendidikan kejuruan; kurikulum pendidikan; mata pelajaran pendidikan kejuruan; strategi pembelajaran; strategi pembelajaran modern
Internationalization of the French Language Curriculum through the Application of the Common European Framework of Reference
Authors: Umaya Siti 
Published: October 2023

The research entitled “Internationalization of the French Language Curriculum through the Application of the Common European Framework of Reference (CEFR) is a descriptive study that aims to provide an overview of the internationalization of the French language curriculum in the French language study program STBA YAPARI ABA Bandung by adopting the CEFR. The form of implementation of the CEFR is carried out in several curriculum components, namely, graduate profiles, graduate learning outcomes (CPL), learning approaches and methods, as well as learning evaluations, especially assessments carried out on the four language skills, namely speaking skills (production orale), writing skills (production écrite)., listening skills (comprehension orale), and reading skills (comprehension écrite). The changes that occurred after the implementation of the CEFR were the addition of a minimum language competency standard of B1 CEFR as a graduate profile and learning outcomes. Furthermore, another change is the use of an action-based approach (actionnelle) and the addition of project-based learning, problem-based learning, and task-learning methods. AbstrakPenelitian yang berjudul “Internasionalisasi Kurikulum Bahasa Prancis melalui Penerapan Common European Framework of Reference (CEFR) merupakan penelitian deskriptif yang bertujuan untuk memberikan gambaran mengenai internasionalisasi kurikulum bahasa Prancis di prodi bahasa Prancis STBA YAPARI-ABA Bandung dengan mengadopsi CEFR. Bentuk penerapan CEFR tersebut dilakukan dalam beberapa komponen kurikulum yaitu profil lulusan, capaian pembelajaran lulusan (CPL), pendekatan dan metode pembelajaran, serta evaluasi pembelajaran khususnya penilaian yang dilakukan terhadap empat keterampilan berbahasa yaitu keterampilan berbicara (production orale), keterampilan menulis (production écrite), keterampilan mendengar (comprehension orale), dan keterampilan membaca (comprehension écrite). Perubahan yang terjadi setelah penerapan CEFR adalah penambahan standar kompetensi berbahasa minimal B1 CEFR sebagai dalam profil lulusan dan capaian pembelajaran. Selanjutnya, perubahan lainnya adalah penggunaan pendekatan berbasis tindakan (actionnelle) dan penambahan metode pembelajaran project-based learning, problem-based learning, dan tugas.Kata Kunci: Bahasa Prancis; CEFR; Internasionalisasi; Kurikulum
Implementation of ISO 9001:2015 in e-Learning services in higher education
Authors: Gunadi Mochamad Rizal Fikri 
Published: October 2023

Needs for using a Learning Management System (LMS) in curriculum development in higher education is increasing, including what has happened at the Bandung Institute of Technology. LMS is not only a complementary medium but also a substitute medium for the learning system during the COVID-19 pandemic. This study aims to determine the process of implementing ISO 9001: 2015 in online learning services at the Directorate of Education Development and assess risk mitigation in overcoming obstacles to the curriculum management process. This research was carried out based on the urgency of the management process in curriculum development to support the achievement of curriculum objectives. The method used in this research is qualitative with a descriptive approach. The findings from this study indicate that the Directorate of Educational Development at the Bandung Institute of Technology has implemented ISO 9001:2015 properly, which means it has carried out its duties according to the applicable rules and regulations. Implementing the LMS at the Bandung Institute of Technology applies several criteria related to the Quality Management System (QMS), which is supported by the PDCA (Plan-Do-Check-Act) process and cycle model so that an organization can achieve the desired results. AbstrakKebutuhan akan pemanfaatan Learning Management System (LMS) dalam pengembangan kurikulum di pendidikan tinggi semakin tinggi, termasuk yang terjadi di Institut Teknologi Bandung. LMS tidak hanya sebagai media komplementer, akan tetapi juga sebagai media substitusi sistem pembelajaran di masa pandemi Covid-19. Penelitian ini bertujuan untuk mengetahui proses penerapan ISO 9001:2015 dalam layanan pembelajaran daring di Direktorat Pengembangan Pendidikan, serta mengetahui mitigasi resiko dalam mengatasi kendala pada proses manajemen kurikulum. Penelitian ini dilaksanakan berdasarkan urgensi proses manajemen dalam pengembangan kurikulum untuk mendukung ketercapaian tujuan kurikulum. Metode yang dilakukan dalam penelitian ini adalah kualitatif dengan pendekatan deskriptif. Hasil temuan yang diperoleh dari penelitian ini menunjukkan bahwa Direktorat Pengembangan Pendidikan di Institut Teknologi Bandung telah mengimplementasikan ISO 9001:2015 dengan baik, dan artinya telah menjalani tupoksinya sesuai aturan dan perundang-undangan yang berlaku. Pelaksanaan LMS di Institut Teknologi Bandung menerapkan beberapa kriterai terkait Sistem Manajemen Mutu (SMM) yang didukung oleh model proses dan siklus PDCA (Plan-Do-Check-Act) sehingga sebuah organisasi dapat mencapai hasil yang diinginkan.Kata Kunci: ISO 9001:2015; learning management system; manajemen kurikulum; pembelajaran daring