bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time trends in real-world treatment patterns and survival in patients diagnosed with de novo HER2+ metastatic breast cancer: an analysis of the SONABRE registry
Authors: Geurts Sandra ME , Ibragimova Khava , Ding Nan , Meegdes Marissa , Erdkamp Frans , Heijns Joan , Tol Jolien , Vriens Birgit , Dercksen Marcus W , Aaldering Kirsten , Pepels Manon , de Winkel Linda van , Peters Natascha , de Wouw Agnes J van , Maaskant Sabrina , Dedroog Nathalie Teeuwen - , Nijnatten Thiemo van , de Boer Maaike , Tjan-Heijnen Vivianne 
Published: October 2023

Abstract

Purpose The aim was to determine whether the real-world first-line progression-free survival (PFS) of patients diagnosed withde novohuman epidermal growth factor receptor 2 positive (HER2+) advanced breast cancer (ABC) has improved since the introduction of pertuzumab in 2013. Methods Included were patients systemically treated forde novoHER2 + ABC in ten hospitals in 2008–2017 from the SONABRE Registry (NCT-03577197). First-line PFS in 2013–2017 versus 2008–2012 was determined using multivariable Cox proportional hazards modelling. First-given systemic therapy and the use of locoregional therapy within the first year following diagnosis were determined per period of diagnosis. Results Median and five-year PFS were 26.6 months and 24% in 2013–2017 (n = 85) and 14.5 months and 10% in 2008–2012 (n = 81) (adjusted HR = 0.65, 95%CI:0.45–0.94). Of patients diagnosed in 2013–2017 versus 2008–2012, 85% versus 60% received HER2-targeted therapy and 59% versus 0% pertuzumab-based therapy as first-given therapy. Respectively 27% and 23% of patients underwent locoregional breast surgery, and 6% and 7% surgery of a metastatic site during the first year following diagnosis. Conclusion The prognosis of patients withde novoHER2 + ABC has improved considerably. Since 2013 one in four patients were alive and free from progression on first-given therapy for at least five years.
Evaluation of Transgender Healthcare in Graduate Medical Education Trainees at a Mississippi Academic Medical Center
Authors: Coats Laura E. , Clericuzio Natalie , Pitts Lauren E. , Lutz Elizabeth A. 
Published: October 2023

Abstract
Background
Transgender patients experience longstanding health disparities influenced by improper training of healthcare professionals. Thus, there is a critical need to train medical professionals on how to care for this diverse population. Incorporating targeted and defined transgender healthcare training among the graduate medical education (GME) curricula could improve healthcare outcomes and alleviate healthcare disparities. The primary aim of this study was to assess transgender healthcare needs among GME trainees at the University of Mississippi Medical Center (UMMC) by evaluating their perceptions.
Methods
We administered a 16-question anonymous and voluntary email survey to all UMMC GME trainees (n = 647) from January to March 2022 (UMMC IRB 2021 − 1037).
Results
A total of n = 126 (19.5%) surveys were completed by primary (n = 52) and non-primary (n = 74) care specialists in all post-graduate years (PGY). Non-primary specialists were more confident in their ability to manage health concerns (36.5% “for the most part”; n = 27) (P < 0.01) and comfortable in caring for transgender patients (37.8% “for the most part”; n = 28) (P = 0.03). However, primary care specialists better recognized that they play a role in promoting transgender health (3.9% “not at all”; n = 2)(P < 0.01) and were more interested in learning about transgender healthcare issues (90.4% “yes”; n = 47)(P < 0.01). PGY did not influence responses among all questions.
Conclusions
This study shows limited confidence and awareness in transgender healthcare among GME trainees at a Mississippi academic medical center. These data indicate the necessity to implement transgender healthcare training and education into the GME curriculum. Yet, the transgender healthcare curricula should be tailored by specialty to create culturally competent and inclusive healthcare providers.
Hemophagocytic Lymphohistiocytosis and Myopericarditis Induced by Campylobacter: A Case Report
Authors: Chang Chia Hua , Kao Chih-Chuan 
Published: October 2023

Abstract
Background:
Hemophagocytic lymphohistiocytosis (HLH) is a severe disorder characterized by excessive activation of the immune system, leading to hypercytokinemia and damage to multiple organs. We report a rare case of HLH with myopericarditis caused by Corynebacterium infection.
Case presentation:
A 28-year-old male patient with a history of hypertension without medicine control presented at the hospital after a four-day fever, decreasing urine amount, rashes on his trunk and limbs, and other symptoms. He was admitted with a provisional diagnosis of atypical infection and allergic skin rash related to diclofenac. However, his condition deteriorated, and he developed shock, tachycardia, chest distress, and bilateral pleural effusion after admission. Further investigations revealed cardiogenic shock related to myopericarditis, and he was transferred to the ICU. In addition, a stool PCR panel subsequently revealed a positive result for Campylobacter. On day 6, he was diagnosed with HLH. Under Klaricid and dexamethasone infusion, leukocytosis, anemia and thrombocytopenia with cardiogenic shock status improved. Then, he was later discharged in stable condition.
Conclusions:
HLH and myopericarditis caused by Campylobacter are very rare. Early detection of Campylobacter-induced HLH and multiple organ failure, as well as prompt use of antibiotics and immunosuppressants, can be helpful for prognosis.
Paediatric drug development in Japan: A study over the past 15 years
Authors: Inagaki Rieko , Narukawa Mamoru 
Published: October 2023

Abstract
Introduction
The number of medicinal products labelled for paediatric use is limited. Regulatory measures to promote paediatric drug development in the US and Europe and the establishment of an international guideline (ICH-E11) have led to an increase in the number of paediatric labels. In Japan, efforts have been made to promote the development of paediatric drugs. This study was to examine whether paediatric drug development is being promoted, and whether off-label drug use by children is decreasing in Japan.
Methods
This study examined the number of new drugs approved for paediatric indications in Japan from 2006 to 2021, as well as the clinical data package, that is, characteristics of the approved paediatric drugs and paediatric clinical trials, and the percentage of extrapolation of adult data, in the most recent five-year period.
Results
The number of paediatric drug approvals underwent a temporary increase between 2006 and 2012. The proportion of drugs indicated for paediatric patients to the total number of approved drugs did not change markedly during the survey period, indicating that off-label use did not decrease. Simultaneous development in adults and children has increased, but the extrapolation of adult data to paediatric populations has not been widely utilized.
Conclusions
In Japan, the number of paediatric drug approvals has shown a slight upward trend but has not yet reached the point of significantly reducing off-label use. Appropriate development strategies, such as the extrapolation of adult data to paediatric populations, should be considered.
What Factors Influence Couples' Decisions for Childbearing? Evidence from a Systematic Scoping Review
Authors: Ranjbar Mohammad , Rahimi Mohammad Kazem , Heidari Edris , Baharinia Sajad , Alimondegari Maliheh , Lotfi Mohammad Hasan , Shafaghat Tahereh 
Published: October 2023

Abstract

BackgroundOne of the most significant demographic challenges over the past three decades has been the substantial reduction in fertility rates, worldwidely. As a developing country, Iran has also experienced a rapid decline in fertility over the past decades. Understanding factors influencing fertility is essential for development programs. Moreover, it's crucial to study the parameters that affect the intention for childbearing in any society. Therefore, through a systematic scoping review, the present study investigates the factors influencing couples' decisions toward childbearing.MethodsThis study was a systematic scoping review conducted in 2023. To design and conduct this scoping review, Joanna Briggs Institute’s Protocol (2015) was used and the framework presented by Levac et al. (2010) was also used as a guide for conducting this review. Studies were searched in three main databases including ISI Web of Sciences, PubMed, and Scopus, using a predefined search strategy. Google Scholar was also used for complementary search. The search period was from 2002 to 2022.ResultsA total of 18,454 studies were identified across three primary databases. After evaluating articles in three distinct phases based on title, abstract, and full-text, 46 articles were deemed eligible for inclusion in the scoping review. The qualitative analysis of the collected data from the selected studies through the scoping review led to classifying factors influencing households' desire for childbearing into eight main themes and 101 sub-themes. The main themes associated with factors impacting households' intention for childbearing encompass individual determinants, demographic and familial influencing factors, cultural elements, social factors, health-related aspects, economic considerations, insurance-related variables, and government support/incentive policies.ConclusionsComprehensive and holistic attention from governments and officials toward the various factors affecting households' intention and behavior regarding childbearing appears beneficial and effective. Furthermore, given the relative ineffectiveness of some of the current government's supportive/incentive policies to increase couples' desire for childbearing, it seems necessary to review and amend these policies. This review should address the most significant challenges and factors contributing to couples' reluctance to childbearing or strengthen factors that can play a substantial role in fostering fertility and childbearing desires.
Human land fragmentation drives tropical forest fires but dampens global burned area
Authors: Bowring Simon , Li Wei , Mouillot Florent , Rosan Thais , Ciais Philippe 
Published: October 2023

Abstract

Landscape fragmentation has been correlated with either increases or decreases in burned area (BA), but their causal mechanisms remain elusive. Here, road density, a fragmentation proxy, is implemented in a CMIP6 coupled land-fire model, enabling dynamic representation of bottom-up processes affecting fragment edges. Over 2000-2013, fragmentation altered BA by >10% in 16% of burned [0.5°] grid-cells and caused gross changes of -6.5% to +5.5% in global BA. Model output mimicked the global satellite-observed negative relationship between fragmentation and BA, although some regional BA decreases were matched by fire intensity increases. In recently-deforested tropical areas, however, fragmentation drove significant, observationally-consistent increases in BA (~1/4 of Brazilian, Indonesian total BA). Fragmentation BA’s relationship with population density is negative globally-averaged, but hump-shaped and largely positive in tropical and temperate forests. We suggest fragmentation could ‘tip’ toward net BA-amplification with future tropical forest degradation and fire-activity, providing policymakers a first quantification of fragmentation-fire risks.
PHLDA2 is a prognostic biomarker associated with tumor immunosuppressive microenvironment in hepatocellular carcinoma
Authors: Chen Bijun , Tang Ying , Wang Biao 
Published: October 2023

Abstract
PHLDA2 (pleckstrin homology-like domain, family A, member 2), is primarily found in the placenta and is known to regulate cell growth and apoptosis. It has also been linked to certain types of cancer, though its role in hepatocellular carcinoma (HCC) is unclear. To investigate further, we conducted a bioinformatic analysis, examining gene expression, prognostic function, potential pathways, the tumor microenvironment, and drug resistance. The analysis revealed that PHLDA2 expression generally increased in various tumors, including HCC, and was associated with worse survival rates. Additionally, PHLDA2 expression correlated positively with most immunosuppressive cells, such as tumor-associated macrophages and Tregs. Patients with elevated PHLDA2 expression tended to be resistant to anti-tumor medications. Overall, our study suggests that PHLDA2 may function as an oncogene and prognostic marker in HCC and other cancers, possibly contributing to an immunosuppressive microenvironment.
Applying Techno-economic Analysis to Evaluate the Economic Value of Residue Reuse of Makino Bamboo (Phyllostachys makinoi)
Authors: Lin Yu-Jen , Zhong Yi-Lin , Liu Wan-Yu 
Published: October 2023

Abstract
The bamboo industry in Taiwan was very prosperous in the early days. However, with the development of the industry, bamboo was replaced by plastics, metals, and composite materials. There are different ways to process bamboo waste from the bamboo processing industry. This study aimed to analyze the economic benefits of different processing methods for Makino waste materials using techno-economic analysis and cost-benefit analysis. This study divided the treatment methods into two categories: (a) remove, discard, and no longer use and (b) reuse to make fuel rods for sale. Category (a) includes one scenario: removing and sending the waste materials to the joss paper processing manufacturer to proceed with incineration and burial. Category (b) was divided into 6 scenarios according to whether they need to bear the cost of equipment and whether they need to hire additional full-time employees. The results show that different analysis methods all point out that Scenario 7 (the manufacturer does not have to bear the cost of equipment and does not hire additional professional employees) is the best solution. If using the net present value method, present value cost method, net annual value method, and annual cost method for evaluation, then scenario 6 (the manufacturer does not have to bear the equipment costs and hire additional professional manpower) and scenario 7 are better than scenario 1 (the bamboo waste was removed). If using the net present value rate method, profitability index method, and self-liquidating ratio for evaluation, then the results show that only scenario 7 is profitable, and no other scenarios should be selected. This means that the production of fuel rods from bamboo waste materials can increase the material output value, help manufacturers create economic benefits, and solve the regional environmental problems caused by the long-term accumulation of waste materials. Therefore, to minimize the waste of resources and through the government subsidizing the cost of equipment, the implementation of the applications of the circular economy can achieve a balance between environmental protection and socioeconomic benefits. It is recommended to apply industry-academia cooperation, hiring students from relevant departments to reduce labor costs and enable students to understand the bamboo industry.
Monitoring volcanic activity with distributed acoustic sensing using the Tongan seafloor telecommunications cable
Authors: Nakano Masaru , Ichihara Mie , Suetsugu Daisuke , Ohminato Takao , Ono Shigeaki , Vaiomounga Rennie , Kula Taaniela , Shinohara Masanao 
Published: October 2023

Abstract
The devastation caused by the January 2022 eruption of Hunga Tonga-Hunga Ha’apai volcano (HTHH) in the Tongan archipelago reminded us of the importance of monitoring shallow-sea volcanic activity. Seismic observations are essential for such monitoring, but there were no operational seismic stations in Tonga at the time of the eruption. There are only a few islands near Tongan volcanoes, and installation and maintenance of seismic stations on remote islands are expensive. Seismic observations based on distributed acoustic sensing (DAS) using a seafloor cable may provide a more practical and economical solution. To investigate the potential of this approach, we made preliminary DAS observations for one week using the seafloor domestic broadband telecommunications cable in Tonga. DAS equipment was installed at the landing station of the seafloor cable at Nuku’alofa on Tongatapu, the main island of Tonga. To provide reference data, we installed several seismometers on Tongatapu. The DAS data we obtained showed high noise levels in areas of shallow coral reef, but noise levels decreased greatly in deeper water areas, indicating that DAS is suitable for seismic observations of the deep seafloor. We detected many local and regional earthquakes during our week of observation and determined 17 earthquake hypocenters by picking P- and S-wave arrival times from the DAS and onshore seismic data. Although most of these were tectonic events related to the subduction of the Pacific plate along the Tonga trench, several events were detected around the volcanic chain of the Tongan archipelago including one event beneath the HTHH crater, implying that activity at HTHH has continued since the 2022 eruption. The much lower cost of installation of DAS equipment compared to that for pop-up type ocean-bottom seismometers and the ability of DAS systems to monitor seismic activity in real-time make it an attractive option for monitoring the activity of HTHH and other volcanoes near seafloor cables in the Tongan archipelago.
Patterns of neural activity in response to threatening faces are predictive of autistic traits: modulatory effects of oxytocin receptor genotype
Authors: Kendrick Keith , Zheng Xiaoxiao , Zhou Feng , Fu Meina , Xu Lei , Wang Jiayuan , Li Jialin , Li Keshuang , Sindermann Cornelia , Montag Christian , Becker Benjamin , Zhan Yang 
Published: October 2023

Abstract
Autistic individuals generally demonstrate impaired emotion recognition but it is unclear whether effects are emotion-specific or influenced by oxytocin receptor (OXTR) genotype. Here we implemented a dimensional approach using an implicit emotion recognition task together with functional MRI in a large cohort of subjects (N = 255) to establish associations between autistic traits and neural and behavioral responses to specific face emotions, together with modulatory effects of OXTR genotype. A searchlight-based multivariate pattern analysis (MVPA) revealed an extensive network of frontal, basal ganglia, cingulate and limbic regions exhibiting significant predictability for autistic traits from patterns of responses to angry relative to neutral expression faces. Functional connectivity analyses revealed a genotype interaction (rs2254298, rs2268491) for coupling between the orbitofrontal cortex and mid-cingulate during angry expression processing, with a negative association between coupling and autistic traits in the risk-allele group and a positive one in the non-risk allele group. Overall, results indicate extensive emotion-specific associations primarily between patterns of neural responses to angry faces and autistic traits in regions processing motivation, reward and salience but not in early visual processing. Functional connections between these identified regions were not only associated with autistic traits but also influenced by OXTR genotype. Thus, altered neural responses to threatening faces may be a potential biomarker for autistic symptoms although modulatory influences of OXTR genotype need to be taken into account.
Propagation of light wave around planets in cosmic space
Authors: Berceli Tibor 
Published: October 2023

Abstract
The propagation of light wave around planets is studied in the paper. There are planets having an atmosphere. The permittivity of atmosphere is high close to the planet surface and gradually decreases with elevation. These planets have an inhomogeneous medium around their surface. Based on the results of our investigations when the light beam propagates parallel to layers of atmosphere, its propagation direction is gradually deviating from the straight line toward higher permittivity layers. This way the light wave follows a curved route. Some planets have no atmosphere. Their surface is not smooth, in addition to plains, there are hills and mountains with varying heights. Therefore, layers of atmosphere parallel to the planet surface can be considered by an equivalent permittivity which is high at the planet surface and gradually decreases with the elevation. As its consequence a tangentially incident light beam deviates from the straight line and follows a curved route. Based on the results of present investigations, it is not necessary to assume that the cosmic space is curved close to a planet containing a huge mass.
Two-year cumulative live-birth rates and maximum number of transfer cycles in women aged &gt;40 years
Authors: Nukaga Sakiko , Tokoro Mikiko , Asano Emiko , Inoue Daichi , Hashiba Yoshiki , Fukunaga Noritaka , Asada Yoshimasa 
Published: October 2023

Abstract

The objective of this retrospective study is to clarify the cumulative live-birth rates (CLBRs) from frozen–thawed embryo transfer without preimplantation genetic testing for aneuploidy (PGT-A) to evaluate the validity of infertility treatment in women of advanced reproductive age. A total of 1,011 patients aged ≥ 40 years undergoing their first nondonor in vitro fertilization without PGT-A at our hospital between January 2010 and September 2017 were included. They were followed up for up to two years, or until either treatment discontinuation or a pregnancy that resulted in a live birth. We also estimated the cost per live birth (LB) for each number of transfer cycles. The 2-year CLBRs were 55.6%, 39.0%, 31.3%, 19.1%, 10.6%, 4.4%, and 0% for patients of ages 40, 41, 42, 43, 44, 45, and > 46, respectively. In approximately 80% cases of LB, the patients aged 40–42 and 43–44 years became pregnant by the fourth and second transfer, respectively. The cost per LB exceeded $150,000 after the fourth, third, and second transfers at the age of 40, 41, and 42–43 years, respectively. Patients who showed no results after a certain number of transfers should be advised to quit fertility treatment.
Expanding chemical space of metal-organic frameworks via up-down approach
Authors: Choe Wonyoung , Kim Jiyeon , Nam Dongsik , Cho Hye Jin , Cho Eunchan , Sivanesan Dharmalingam 
Published: October 2023

Abstract

Metal-organic frameworks (MOFs) have become materials platform with vast structural diversity, tailorable for broad practical applications. Traditional bottom-up and top-down design approaches played a pivotal role for a rapid increase in MOF structures, yet the systematic screening for unknown synthesizable MOFs is still a daunting challenge. Herein, we developed a novel search paradigm, the Up-Down Approach (UDA), by merging the bottom-up and top-down approaches. Targeting the famous class of Zr-based MOFs, we searched promising topology candidates and unveiled 17 future structural configurations by considering the possible orientations of Zr6 clusters. Through ribbon representation and sophisticated analysis of the ligand angles, we suggested future structure models and successfully synthesized one of the suggested structures with a novel scu configuration. The UDA will accelerate the discovery of hidden MOFs, providing exciting new opportunities to effectively expand the chemical space of MOFs.