bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel search strategy for right-handed charged gauge bosons at the Large Hadron Collider
Authors: Frank Mariana , Fuks Benjamin , Jueid Adil , Moretti Stefano , Özdal Özer 
Published: February 2024

Abstract
We explore the potential of the Large Hadron Collider (LHC) in detecting a signal originating from the production of a heavy SU(2)R charged gauge boson that then decays into a top-bottom quark pair via the mediation of a right-handed neutrino, pp → WR → NRℓ → (ℓ′tb)ℓ. Such a channel, that we study in the context of the minimal Left-Right Symmetric Model, contrasts with conventional smoking-gun signatures targeted experimentally and phenomenologically in which only light quarks are involved. We propose a selection strategy aimed at extracting such a top-bottom signal and we estimate the resulting sensitivity of the LHC to the model. Our results demonstrate the potential impact of such a search and we therefore urge the experimental collaborations to carry out a similar analysis in the light of present and future data.
From one to infinity: symmetries of integrable systems
Authors: Lou S. Y. , Jia Man 
Published: February 2024

Abstract
Integrable systems constitute an essential part of modern physics. Traditionally, to approve a model is integrable one has to find its infinitely many symmetries or conserved quantities. In this letter, taking the well known Korteweg-de Vries and Boussinesq equations as examples, we show that it is enough to find only one nonlocal key-symmetry to guarantee the integrability. Starting from the nonlocal key-symmetry, recursion operator(s) and then infinitely many symmetries and Lax pairs can be successfully found.
Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis
Authors: Pati Debananda 
Published: February 2024

AbstractCell division is a crucial process, and one of its essential steps involves copying the genetic material, which is organized into structures called chromosomes. Before a cell can divide into two, it needs to ensure that each newly copied chromosome is paired tightly with its identical twin. This pairing is maintained by a protein complex known as cohesin, which is conserved in various organisms, from single-celled ones to humans. Cohesin essentially encircles the DNA, creating a ring-like structure to handcuff, to keep the newly synthesized sister chromosomes together in pairs. Therefore, chromosomal cohesion and separation are fundamental processes governing the attachment and segregation of sister chromatids during cell division. Metaphase-to-anaphase transition requires dissolution of cohesins by the enzyme Separase. The tight regulation of these processes is vital for safeguarding genomic stability. Dysregulation in chromosomal cohesion and separation resulting in aneuploidy, a condition characterized by an abnormal chromosome count in a cell, is strongly associated with cancer. Aneuploidy is a recurring hallmark in many cancer types, and abnormalities in chromosomal cohesion and separation have been identified as significant contributors to various cancers, such as acute myeloid leukemia, myelodysplastic syndrome, colorectal, bladder, and other solid cancers. Mutations within the cohesin complex have been associated with these cancers, as they interfere with chromosomal segregation, genome organization, and gene expression, promoting aneuploidy and contributing to the initiation of malignancy. In summary, chromosomal cohesion and separation processes play a pivotal role in preserving genomic stability, and aberrations in these mechanisms can lead to aneuploidy and cancer. Gaining a deeper understanding of the molecular intricacies of chromosomal cohesion and separation offers promising prospects for the development of innovative therapeutic approaches in the battle against cancer.
Saw-box osteotomy versus reamer-box osteotomy in posterior stabilized total knee arthroplasty: a retrospective study of an average five year follow-up
Authors: Abdelbadie Ahmed , Toreih Ahmed A. , El-Adawy Moawed F. , Arafa Mohamed S. 
Published: February 2024

Abstract
Purpose
The purpose of this study is to compare the difference of results between two methods of femoral box osteotomy adopted by two designs of posterior stabilized total knee prostheses.

Patients and methods
Retrospective analysis of the results of two groups of patients operated upon using two primary PS TKA systems, PFC Sigma (DePuy Synthes, Johnson and Johnson®) and Genesis II prosthesis (Smith and Nephew®), with an average of five year follow-up was done. Group 1 included 152 knees in 121 patients and group 2 included 122 knees in 111 patients. The average follow-up period in both groups was five years. The box osteotomy method depends on bone saw in group 1, and bone reamer in group 2.

Results
The KSS score of group 2 was better in the first six months postoperatively. Then, no significant differences were seen in the remaining follow-up visits. The risk of periprosthetic fractures was significantly higher in group 1 (p-value 0.040). Survival analysis showed a significantly shorter time for reoperation in group 1 than in group 2 as described by log-rank test, (p < 0.006).

Conclusion
The method of box cutting has an impact on the function and longevity of posterior stabilized primary knee implants. The risk of periprosthetic fractures can be reduced by proper patient selection, decreasing the box sizes, and development of more “controlled” box osteotomy instruments.
Systemic interrogation of immune-oncology-related proteins in patients with locally advanced prostate cancer undergoing androgen deprivation and intensity-modulated radiotherapy
Authors: Guldvik Ingrid Jenny , Ramberg Håkon , Kristensen Gitte , Røder Andreas , Mills Ian G. , Lilleby Wolfgang , Taskén Kristin Austlid 
Published: February 2024

Abstract
Purpose
The primary objective was to establish whether blood-based leucine-rich alpha-2-glycoprotein (LRG1) can predict outcomes in patients with locally advanced prostate cancer undergoing androgen-deprivation therapy (ADT) and radiotherapy (RT) and to determine how it may relate to 92 immune-oncology (I-O)-related proteins in this setting.

Methods
Baseline blood level of LRG1 from patients treated with ADT and RT enrolled in the CuPCa (n = 128) and IMRT (n = 81) studies was measured using ELISA. A longitudinal cohort with matched blood samples from start of ADT, start of RT, and end of RT protocol from 47 patients from the IMRT cohort was used to establish levels of I-O proteins by high-multiplexing Proximal Extension Assay by Olink Proteomics.
Statistical analyses using Kaplan–Meier, Cox regression, and LIMMA analyses were applied to predict the prognostic value of LRG1 and its correlation to I-O proteins.

Results
High baseline levels of LRG1 predicted a low frequency of treatment failure in patients undergoing ADT + RT in both the CuPCa and the IMRT cohorts. LRG1 was moderately correlated with CD4, IL6, and CSF1. We identified I-O proteins predicting metastatic failure (MF) at different timepoints.

Conclusion
LRG1 biomarker is associated with I-O proteins and can be used to improve stratification and monitoring of prostate cancer patients undergoing ADT + RT. This work will require further in-depth analyses in independent cohorts with treatment outcome data.

Graphical abstract
Study outline. A) Study cohorts. B) Sampling time points in a longitudinal cohort.
The Lavrentiev phenomenon in calculus of variations with differential forms
Authors: Balci Anna Kh. , Surnachev Mikhail 
Published: February 2024

AbstractIn this article we study convex non-autonomous variational problems with differential forms and corresponding function spaces. We introduce a general framework for constructing counterexamples to the Lavrentiev gap, which we apply to several models, including the double phase, borderline case of double phase potential, and variable exponent. The results for the borderline case of double phase potential provide new insights even for the scalar case, i.e., variational problems with 0-forms.
Elucidating molecular mechanisms and therapeutic synergy: irreversible HER2-TKI plus T-Dxd for enhanced anti-HER2 treatment of gastric cancer
Authors: Liu Jiankun , Zhu Tienian , Zhao Ruijing , Ren Wenjun , Zhao Fei , Liu Jingpu 
Published: February 2024

Abstract
Background
HER2-targeted therapies have improved the outcomes of HER2-positive gastric cancer (GC), yet resistance remains a challenge. We sought to explore the effects of reversible and irreversible HER2 tyrosine kinase inhibitors (TKIs) alone or in combination with the HER2-targeting antibody drug conjugate trastuzumab deruxtecan (T-Dxd).

Methods
The effects of HER2-TKIs on HER2 and downstream signaling were evaluated via Western blotting. Proteasomal inhibitors and co-immunoprecipitation assays were performed to explore the role of proteasomal degradation in HER2 expression modulation, and immunofluorescence assays were employed to explore mechanisms of HER2 internalization. The synergistic potential of the irreversible HER2-TKI pyrotinib in combination with T-Dxd was validated using growth and viability assays in anti-HER2-positive GC cell cultures and tumor growth and immunohistochemical staining assays in a mouse xenograft model.

Results
Our study revealed that reversible HER2-TKIs elevated HER2 protein levels, whereas irreversible HER2-TKIs decreased them. Pyrotinib triggered HER2 degradation within the proteasome by promoting ubiquitination and dissociation from HSP90. Furthermore, pyrotinib substantially induced HER2 internalization, which led to improved cellular uptake of T-Dxd. The increased T-Dxd uptake was accompanied by greater efficacy in suppressing the growth of GC cells and enhanced anti-tumor effects in an animal model.

Conclusion
In summary, our research reveals the molecular mechanisms of irreversible HER2-TKIs in regulating HER2 protein expression by promoting HER2 internalization. These findings advance our comprehension of targeted therapy for GC and provide a promising therapeutic combination strategy with enhanced efficacy against HER2-positive GC.
Immune checkpoint inhibitors and risk of immune-mediated adverse events: a cohort study comparing extended versus standard interval administration
Authors: Lessard-Roy Amélia , Marchand Roxanne , Lemieux Pierre , Masse Mélanie , Lacerte Alexandre , Carmichael Pierre-Hugues , Laurin Danielle 
Published: February 2024

AbstractThe COVID-19 pandemic precipitated the implementation of extended interval immune checkpoint inhibitors (ICIs) in an effort to limit hospital visits, but few studies have examined their safety. This study aimed to compare in oncology outpatients, immune-mediated adverse events (IMAEs) in terms of total number, incidence, severity, and time to occurrence, based on exposure to standard or extended interval ICIs. A retrospective cohort study was conducted in patients who received at least one dose of an ICI between 2015 and 2021. Data were collected from patient records and pharmacy software. Adjusted logistic, Poisson, and Cox regression models were estimated. A total of 310 patients with a mean age of 67.1 years were included, 130 of whom had the extended interval. No statistically significant differences were observed between the groups. With the standard and extended intervals, the mean total number of IMAE per participant was 1.02 and 1.18, respectively; the incidence of an IMAE was 62% and 64%. Of the 147 IMAE episodes in the standard interval group, 14 (9.5%) were grade 3 or higher, while there were 15 (12.4%) among the 121 IMAE episodes in the extended interval group. Compared with standard interval, the use of extended interval did not increase the risk of having a first IMAE (adjusted hazard ratio 0.92 (95% CI 0.67–1.26)). This study suggests that the administration of an ICI according to extended interval is as safe as the administration according to standard interval in oncology outpatients.
Halved contrast medium dose coronary dual-layer CT-angiography – phantom study of tube current and patient characteristics
Authors: Kristiansen C. H. , Tetteroo P. M. , Dobrolinska M. M. , Lauritzen P. M. , Velthuis B. K. , Greuter M.J.W. , Suchá D. , de Jong P.A. , van der Werf N.R. 
Published: February 2024

AbstractVirtual mono-energetic images (VMI) using dual-layer computed tomography (DLCT) enable substantial contrast medium (CM) reductions. However, the combined impact of patient size, tube voltage, and heart rate (HR) on VMI of coronary CT angiography (CCTA) remains unknown. This phantom study aimed to assess VMI levels achieving comparable contrast-to-noise ratio (CNR) in CCTA at 50% CM dose across varying tube voltages, patient sizes, and HR, compared to the reference protocol (100% CM dose, conventional at 120 kVp). A 5 mm artificial coronary artery with 100% (400 HU) and 50% (200 HU) iodine CM-dose was positioned centrally in an anthropomorphic thorax phantom. Horizontal coronary movement was matched to HR (at 0, < 60, 60–75, > 75 bpm), with varying patient sizes simulated using phantom extension rings. Raw data was acquired using a clinical CCTA protocol at 120 and 140 kVp (five repetitions). VMI images (40–70 keV, 5 keV steps) were then reconstructed; non-overlapping 95% CNR confidence intervals indicated significant differences from the reference. Higher CM-dose, reduced VMI, slower HR, higher tube voltage, and smaller patient sizes demonstrated a trend of higher CNR. Regardless of HR, patient size, and tube voltage, no significant CNR differences were found compared to the reference, with 100% CM dose at 60 keV, or 50% CM dose at 40 keV. DLCT reconstructions at 40 keV from 120 to 140 kVp acquisitions facilitate 50% CM dose reduction for various patient sizes and HR with equivalent CNR to conventional CCTA at 100% CM dose, although clinical validation is needed.
The moderating effect of creative metacognition on adolescents’ risk-taking in creative performance
Authors: Woo Jungmin , Lee Seon-Young 
Published: February 2024

AbstractResearch has demonstrated the crucial role of creative metacognition and risk-taking in creativity. However, little empirical research has examined how creative metacognition and risk-taking work on creative performance in educational practice. This paper explored the moderating effects of creative metacognition on the relationships between different types of risk-taking (i.e., propensity for taking a risk, willingness to take a risk) and creative performance (i.e., general creativity, originality, usefulness) in a middle school context. The sample consisted of 350 7th- and 8th-grade students from three middle schools. They completed a survey and a creative performance task. Hierarchical regression analysis revealed that creative metacognition moderated the relationships between willingness to take a risk and both originality and usefulness. The results indicated that creative metacognition reinforces the positive effect of risk-taking on originality and mitigates the negative effect of risk-taking on usefulness. Our findings suggest a potential role for creative metacognition in enhancing curriculum-based creative performance in middle schools. In the end, practical implications, limitations, and future directions are discussed.
A novel score system to evaluate carbonate reservoir combining microscale and macroscale parameters
Authors: Xu Huilin , Wang Guanqun , Xu Wei , Luo Wenjun , Han Dan , Xiong Zhao , Xiao Fan , Shao Haipeng , Yan Jucai , Long Wei 
Published: February 2024

AbstractThe central Sichuan Basin, located in western China, holds great significance in terms of hydrocarbon production, especially in relation to complex carbonate reservoirs, notably the Qixia Formation of the Middle Permian epoch. However, the comprehensive evaluation of this geological formation presents considerable challenges due to complex lithology, limited availability of reservoir property data at various scales, inadequacies in data integration, and the absence of a reliable reservoir ranking system for development decision making. Previous studies primarily relying on conventional data at the reservoir level, such as well logs and geological information, have proven insufficient in accurately characterizing the reservoir. This is especially evident without precise lithological information and detailed knowledge of microscale properties, which are crucial for effective reservoir evaluation. To address these challenges, this study integrates advanced technologies like X-ray diffraction, micro-CT and scanning electron microscope (SEM) techniques in digital drill cutting analysis at the microscale. A novel scoring system has been developed using a prominent component analysis (PCA) approach and an expert scoring system, which incorporates existing conventional well log data and digital cutting analysis. This scoring system has been validated using actual production data, thus establishing a robust evaluation methodology for assessing the exploration potential and optimizing development strategies for carbonate gas reservoirs in the Qixia Formation. The innovative approach, which incorporates parameters at both micro- and macroscales, holds promising potential in facilitating future exploration and development efforts.
Utilization of machine learning for the estimation of production rates in wells operated by electrical submersible pumps
Authors: Agwu Okorie Ekwe , Alkouh Ahmad , Alatefi Saad , Azim Reda Abdel , Ferhadi Razaq 
Published: February 2024

AbstractIn this study, a neural network model is developed for the prediction of oil flow rates in wells lifted by electrical submersible pumps (ESPs). Three attributes of the model in this work make this study unique. First, the knowledge on the computational cost of models has been presented, a rarity in most neural network models on this subject; second, the models have been explicitly presented, a feature uncommon in published ANN predictive modelling studies; and third, it includes a sensitivity analysis of input variables. The dataset utilized for the model development comprises 275 data points collected from ESP-lifted wells in the Middle East. Statistical evaluation of the model’s performance using the metrics such as mean square error, root mean square error and coefficient of determination demonstrates high predictive accuracy with respective values of 0.0000201861, 0.00449 and 0.999. In order to ascertain the parametric importance of the inputs, Garson’s algorithm was utilized. In this regard, choke size and upstream pressure had the highest influence (19% and 16%, respectively), while casing head pressure had the least effect (4.8%) on oil flow rate. In terms of memory requirements and processing speed for software applications, the model had a memory footprint of 888 bytes and required 191 multiply and accumulate operations to give an output. By utilizing the proposed models, the time-consuming separator tests measurements of flow rate would no longer be necessary and real-time results could be provided in the field. This work would be useful to production engineers who seek a quick and accurate means of estimating oil flow rate from ESP wells in real time.
The genome, pangenome, and physiological analysis of Leclercia adecarboxylata (kcgeb_e1), a plant growth-promoting bacterium
Authors: Saeed Esam Eldin , Sudalaimuthuasari Naganeeswaran , Purayil Fayas Thayale , Rafi Mohammed , Kundu Biduth , Mishra Ajay Kumar , Al-Maskari Raja Saeed , Abdelfattah Amira Mohamed , Eldin Afaf Kamal , George Suja , Procter Miranda , Hazzouri Khaled M. , Amiri Khaled MA 
Published: February 2024

AbstractPlant growth-promoting bacteria (PGPB) as biofertilizer plays an important role in agriculture practices. In this study, we isolated and identified plant-associated bacteria Leclercia adecarboxylata (kcgeb_e1) from the root region of the halophytic plant Sesuvium verrucosum. We tested its physiological activity and the effect of inoculation, with and without salt, on photosynthesis using Cajanus cajan. Further, we sequenced the whole genome of L. adecarboxylata (kcgeb_e1) and carried out pangenome analysis with 12 other genomes of the same species, which highlights unique genes enriched for pathways involved in abiotic stress tolerance (salinity, drought and heat) and carbohydrate transport. Moreover, gene families involved in abiotic stress tolerance, host adhesion, and transport were under positive selection (e.g., Aldo/keto reductase family, Hemagglutinin, Porin, and sugar transport). We observed a loss of ACC deaminase gene in this pangenome; however, this strain can still produce 1-aminocyclopropane-1-carboxylate (ACC), an enhancer of abiotic stress, which suggests that its homologue, d-cysteine sulfatase, has a bifunctional activity. In addition, this strain has Indole acetic acid (IAA) and phosphate solubilization activity. Combining these findings with the efficiency of colonizing the root surface of Solanum lycopersicum, this strain showed remarkable enhancement of photosynthesis, comparing control to inoculated plants. This increase in photosynthesis is consistent with an increase in sucrose under salt treatment, but not in glucose and fructose, which acts as a sensor in opposing the negative effect of salinity and promoting sustainable growth. Given all this, our study suggests that this PGPB can act as a biofertilizer for sustainable agriculture.
Harnessing the foundation of biomedical waste management for fostering public health: strategies and policies for a clean and safer environment
Authors: Singh Harpreet , YT Kamal , Mishra Arun Kumar , Singh Mhaveer , Mohanto Sourav , Ghumra Shruti , Seelan Anmol , Mishra Amrita , Kumar Arvind , Pallavi Janardhan , Ahmed Mohammed Gulzar , Sangeetha Jeyabalan , Thangadurai Devarajan 
Published: February 2024

AbstractThe COVID-19 pandemic has led to an enormous rise in biomedical waste and plastic trash production. The sudden increase in the production of waste vehicles carrying the same for disposal presented major challenges for the current waste disposal systems, particularly in developing countries. Due to the COVID-19 health emergency, the significance of appropriate waste management has become more evident. This review aims to showcase all aspects of biomedical waste, including its management, safe disposal approaches, the risks associated with improper waste management, and other hazards from hospitals, labs, and the environment. The focus has been laid on the possible role of laboratories in hospitals, research, and academic institutions directly and indirectly involved in handling biomedical items. It is pertinent to mention that policies relating to biomedical waste management must be renewed periodically for updates and to incorporate new research and system development points. In the present review, establishing collaboration among hospitals, laboratories, and research staff is vital for proper waste management in healthcare facilities. The review demonstrates the contemporary directions in biomedical waste treatment and safe disposal methods, especially incineration, autoclaving, chemical disinfection, and land disposal. Good laboratory practices and techniques for destroying needles, shredders, encapsulation, and inertization are also covered. The significance of biomedical waste management policies in promoting environmentally responsible and safe practices and amendments to these policies has been emphasized.