bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered Protein Binding of Quinidine in Patients with Atrial Fibrillation and Flutter
Authors: McCollam Patrick L. , Crouch Michael A. , Watson Jerry E. 
Published: October 2023

Study Objectives. To determine if α1‐acid glycoprotein (AAG) concentrations are altered in patients with atrial fibrillation and flutter (AFF), and to establish if fluctuations in AAG change the free fraction of quinidine.Design. Prospective, controlled, nonrandomized.Setting. Tertiary care medical center and outpatient clinics.Patients. Thirty patients with AFF and 16 matched controls.Interventions. Serial blood samples were collected from patients with AFF at baseline and for 28 days after cardioversion. The control group received no treatment and a single blood sample was obtained.Measurements and Main Results. Concentrations of AAG were measured by Laurell‐Rocket immunoelectrophoresis. Quinidine concentrations were determined by fluorescence polarization immunoassay using the Abbott TDx system. Baseline AAG concentrations in patients with AFF (122 ± 55 mg/dl) were significantly increased compared with the control group (62 ± 28 mg/dl, p<0.0005). Concentrations of AAG remained elevated after conversion to sinus rhythm and did not significantly change over the study period, regardless of method of cardioversion (p>0.2). In patients with AFF, the free fraction of quinidine at the highest AAG concentration was 8.5 ± 2.3%. This was significantly reduced compared with the value in the control group (12.5 ± 3.0%, p<0.05) as well as that in patients with AFF at the lowest AAG concentration (11.0 ± 2.5%, p<0.05). Overall at the highest AAG concentration, patients with AFF had a relative reduction in the quinidine free fraction by 32% compared with controls. Regression analysis showed an indirect relationship between serum AAG concentration and the unbound fraction of quinidine (r=0.56)Conclusions. Concentrations of AAG are increased in patients with AFF and remain elevated for at least 28 days after cardioversion. Elevated AAG concentrations significantly reduce the free fraction of quinidine.
Germline heterozygous SH2B3‐mutations and (idiopathic) erythrocytosis: Detection of a previously undescribed mutation
Authors: Vermeersch Gaël , Devos Timothy , Devos Helena , Lambert Frédéric , Poppe Bruce , Van Hecke Sam 
Published: October 2023

AbstractErythrocytosis or polycythemia refers to a true or apparent increase in hemoglobin or hematocrit. When no etiology of erythrocytosis is identified, people are diagnosed with “idiopathic erythrocytosis” (IE). The identification of new contributing genes has recently improved the diagnostic workup of IE. As such mutations within the SH2B3 gene, which codes for the LNK protein and negatively regulates the JAK‐STAT pathway, have been identified in cases diagnosed as IE. This reports describes the presence of a previously undescribed germline SH2B3 variant p.(Thr335ArgfsTer4) within IE and emphasizes the advantages of gene panel sequencing as second step in the diagnostic work‐up.
Prediction of H3K27M Alteration Status in Brainstem Glioma Using Multi‐Shell Diffusion MRI Metrics
Authors: Xu Xiaolu , Zhang Peng , Zhuo Zhizheng , Duan Yunyun , Qu Liying , Cheng Dan , Sun Ting , Ding Jinli , Xie Cong , Liu Xing , Haller Sven , Barkhof Frederik , Ye Chuyang , Zhang Liwei , Liu Yaou 
Published: October 2023

BackgroundMulti‐shell diffusion characteristics may help characterize brainstem gliomas (BSGs) and predict H3K27M status.PurposeTo identify the diffusion characteristics of BSG patients and investigate the predictive values of various diffusion metrics for H3K27M status in BSG.Study TypeProspective.PopulationEighty‐four BSG patients (median age 10.5 years [IQR 6.8–30.0 years]) were included, of whom 56 were pediatric and 28 were adult patients.Field Strength/Sequence3 T, multi‐shell diffusion imaging.AssessmentDiffusion kurtosis imaging and neurite orientation dispersion and density imaging analyses were performed. Age, gender, and diffusion metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity, radial diffusivity (RD), mean kurtosis (MK), axial kurtosis (AK), radial kurtosis, intracellular volume fraction (ICVF), orientation dispersion index, and isotropic volume fraction (ISOVF), were compared between H3K27M‐altered and wildtype BSG patients.Statistical TestsChi‐square test, Mann–Whitney U test, multivariate analysis of variance (MANOVA), step‐wise multivariable logistic regression. P‐values <0.05 were considered significant.Results82.4% pediatric and 57.1% adult patients carried H3K27M alteration. In the whole group, the H3K27M‐altered BSGs demonstrated higher FA, AK and lower RD, ISOVF. The combination of age and median ISOVF showed fair performance for H3K27M prediction (AUC = 0.78). In the pediatric group, H3K27M‐altered BSGs showed higher FA, AK, MK, ICVF and lower RD, MD, ISOVF. The combinations of median ISOVF, 5th percentile of FA, median MK and median MD showed excellent predictive power (AUC = 0.91). In the adult group, H3K27M‐altered BSGs showed higher ICVF and lower RD, MD. The 75th percentile of RD demonstrated fair performance for H3K27M status prediction (AUC = 0.75).Data ConclusionDifferent alteration patterns of diffusion measures were identified between H3K27M‐altered and wildtype BSGs, which collectively had fair to excellent predictive value for H3K27M alteration status, especially in pediatric patients.Evidence Level2Technical EfficacyStage 3
Unveiling the bioactivity and bioaccessibility of phenolic compounds from organic coffee husks using an in vitro digestion model
Authors: Abreu Thaianaly Leite , Estévez Mario , de Carvalho Leila Moreira , de Medeiros Lorena Lucena , da Silva Ferreira Valquíria Cardoso , Salu Bruno Ramos , Oliva Maria Luiza Vilela , Madruga Marta Suely , Bezerra Taliana Kênia Alencar 
Published: October 2023

AbstractBACKGROUNDThe large quantities of by‐products generated in the coffee industry are a problem. Studies related to the biological potential of organic coffee husks are still limited. The aim of this work was to investigate the occurrence of phenolic compounds in organic coffee husks and to evaluate their potential as a source of bioactive dietary components.RESULTSTo achieve this objective, three extracts were prepared, namely extractable polyphenols (EPs), hydrolyzable non‐extractable polyphenols (H‐NEPs), and non‐extractable polyphenols (NEPs). These extracts were characterized and evaluated for their bioactive properties after simulated gastrointestinal digestion. The results show that the extraction process affected the occurrence of phenols from coffee peels, especially for caffeic acid, gallic acid, and chlorogenic acid. The free and bound polyphenols found in the extracts and digests not only showed antioxidant properties against 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radicals but were also strongly bioavailable and had good anticoagulant potential.CONCLUSIONThese results highlight the potential health benefits of phytochemicals from coffee husks and open new perspectives for the use of such compounds in dietary supplements. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Acute pityriasis rubra pilaris triggered by COVID‐19
Authors: Soto‐García Diego , Oro‐Ayude Marcos , Álvarez Carlos , Martínez‐Fernandez Sandra , Couselo‐Rodríguez Carmen , Flórez Ángeles 
Published: October 2023

AbstractPityriasis rubra pilaris (PRP) can be triggered by viruses, such as cytomegalovirus, Epstein‐Barr virus, varicella zoster, human immunodeficiency virus and, more exceptionally, SARS‐CoV‐2. We report an additional case of PRP following COVID‐19 infection. Given the existing literature and the close temporal association, we suggest a possible causal relationship. We speculate that an altered immune response with a genetic predisposition for PRP may have played a role in our patient. We highlight the development of PRP as part of the spectrum of COVID‐19 skin‐related conditions.
Design of aromatic copolyesters for use in microelectronic devices
Authors: Schneggenburger Lizabeth A. , Economy James E. , Hong Soon Man 
Published: October 2023

AbstractThe next generation of microelectronic devices will require design of new kinds of polymers which are tailored to display a dielectric constant as low as 2.0, a coefficient of thermal expansion (CTE) which matches the metal circuitry as well as the silicon substrate, moisture and chemical resistance, and dimensional stability at processing temperatures of 300‐400°C which are required to form an adhesive bond between laminates.In our program, we have made significant progress in all of these areas through the use of liquid crystalline copolyesters (LCP's) laminated with a newly developed crosslinkable copolyester.In this paper, data are presented which illustrate how films and coatings of either system can be made to adhere in the solid state by interchain transesterification reactions (ITR) at the interface. Ability to foam the crosslinkable copolyester films provides direct control over the dielectric constant. The effect of pore size and distribution on the dielectric constant will be discussed. The potential to dramatically increase the melting point of the LCP's through high temperature annealing is also discussed.
Modification of standardized precipitation index in different climates of Iran
Authors: Nadi Mehdi , Shiukhy Soqanloo Saeid 
Published: October 2023

AbstractThe most popular metric for drought monitoring is the standardized precipitation index (SPI). It does have some drawbacks, though, such as using gamma probability distribution function as the default distribution and not taking into account seasonal variations. The effectiveness of SPI in monitoring droughts in various Iranian climates was examined in this study, and in order to address its limitations, it was contrasted with the modified SPI (mod‐SPI). Then, the performance of the mod‐SPI and SPI in drought monitoring was compared with nine meteorological stations throughout Iran during the period 1956–2010. The results showed that the gamma distribution function was not selected in any of the 12 timescales (TS) considered at the studied meteorological stations. Based on the Cohen's kappa index analysis, there is a clear difference between the SPI and mod‐SPI in monitoring drought classes, which is more evident at low TS (less than 6 months), but at much higher TS (above TS‐9), the two indices almost coincide. The results showed that in the arid and semiarid areas, the SPI and mod‐SPI are significantly different, so it seems that the SPI monitors aridity rather than drought. The results imply that using mod‐SPI instead of SPI provides more accurate drought monitoring by eliminating the seasonal effects of precipitation data. Considering the low efficiency of SPI in short‐term drought monitoring (less than 9 months) in arid and semiarid regions, it is recommended to use mod‐SPI instead of SPI in most parts of Iran, especially on the southern coasts of Iran.
“We want to be heard”: A qualitative study of mental health care access among patients of an urban federally qualified health center
Authors: So Marvin , Makofane Jacob , Hernandez Miguel 
Published: October 2023

AbstractAlthough depression is common in primary care, challenges to timely intervention exist, particularly for communities of color and lower socioeconomic status. Our objective was to understand barriers and facilitators to mental healthcare access among a sample of patients receiving care at a federally qualified health center (FQHC) in Minnesota, United States. We qualitatively interviewed 34 patients of an urban FQHC, purposively sampled on race/ethnicity, insurance status, language, and depression symptom status (based on Patient Health Questionnaire‐9 responses). We inductively and deductively analyzed interview data, leveraging theory in both the codebook development and analysis processes. Participants, who were predominantly English‐speaking, female, not privately insured, and people of color, shared numerous barriers and facilitators to accessing mental healthcare. Prominent barriers primarily concerned healthcare providers, including perceived dismissal of mental health concerns and challenges with provider continuity. Additional barriers included the costs of mental health care, communication breakdowns, the patient portal, and community‐specific perceptions of mental health. Prominent facilitators included clinic organizational factors (internal and external) and staff friendliness and warmth. Other factors including consideration of patients' financial situation, integrated management of behavioral and physical health conditions, language concordant staff, the telehealth visit modality, and the clinic's social mission were also raised as facilitating access. Patient voices from a single FQHC illustrate the challenges and possibilities of providing mental healthcare in safety net settings. Clinical, strategy, and policy solutions can be tailored to minimize barriers and optimize facilitators documented herein.
Power electronics converters for an electric vehicle fast charging station based energy storage system and renewable energy sources:Hybridapproach
Authors: Gopal Soundra Devi , Jawahar Rahila , Athmanathan Radhika , Pandi Meenalochini 
Published: October 2023

AbstractA hybrid method is proposed for electric‐vehicle (EV) fast charging station (FCS)‐based power electronics converters with energy‐storage‐systems (ESS) and renewable‐energy‐sources (RESs). The proposed approach is the combination of the fire hawk optimizer (FHO) and gradient boost decision tree (GBDT) algorithms; hence called as FHO‐GBDT approach. The key objective of the FHO‐GBDT approach is to lessen the peak power demand on the grid. The proposed method is incorporated into EV‐FCS with the capability of a mixture of RESs and energy‐storage‐systems. The capacities of energy‐storage aid in improving power‐demand by lessening the demand for peak power. The structure of the energy storage system minimizes the net cost of the DC micro‐grid (MG). The ESS is mostly composed of batteries, which are reused by EVs. The proposed approach and the ESS enable a decrease in obtaining the greatest amount of power possible from the power‐grid (PG). By then, the performance of the proposed approach is simulated in MATLAB, and it is compared to various existing methods. The simulation result shows that the proposed method offers more power than the existing methods.
An embedding observer for nonlinear dynamical systems with global convergence
Authors: Gerbet Daniel , Röbenack Klaus 
Published: October 2023

AbstractState observers for nonlinear systems are often designed for a canonical form of this system. However, this form may possess singular points, where the vector field is not defined or a Lipschitz condition is not fulfilled. This unpleasant behavior can possibly be avoided using an embedding into a higher dimensional space. A construction of such an embedding and the corresponding inverse map is discussed for polynomial systems using methods from algebraic geometry.
Clumped isotope analysis of (bio)apatite using a Kiel IV device in long‐integration dual‐inlet mode
Authors: Tagliavento Mattia , Hofmann Sven , Böttcher Michael Ernst , Peltz Markus , Fiebig Jens 
Published: October 2023

RationaleClumped isotope (Δ47) analysis of bioapatite‐derived CO2 is a powerful tool to determine body temperatures of extinct vertebrates. The common acid bath technique in combination with dual‐inlet‐based mass spectrometric measurements has been the preferred method of choice for this purpose, but the large amount of material necessary and the presence of secondary calcite represent obstacles.MethodsWe analyzed the Δ47 composition of carbonate‐bearing (bio)apatites using a Kiel IV device, which – in general – allows a reduction of sample replicate size by a factor of ~40 over dual‐inlet‐based techniques. The Kiel IV device was tested in two different modes: without and with additional water sinks for improved water removal. Furthermore, we tested a pretreatment technique based on 1 M acetic acid (pH = 5) to selectively remove secondary calcite from the carbonate‐bearing (bio)apatite phase.ResultsSignificantly lower Δ47 values were obtained for a given bioapatite after the installation of the two water sinks. With this setup, Δ47 of (bio)apatites followed a temperature relationship that is indistinguishable from the unified one for pure carbonates, provided a dentine sample, rich in organic matter, was excluded. The original bioapatite Δ47 value was restored from a bioapatite/calcite mixture if the mixed material was treated for 1 h with 1 M acetic acid (pH = 5).Conclusions(Bio)apatites having low organic matter content such as enamel(oid) can be analyzed accurately for Δ47 using a Kiel IV equipped with water sinks that ensure effective removal of water. Secondary calcite can be effectively removed from carbonate‐bearing apatite by pretreatment with 1 M acetic acid (pH = 5) for 1 h.
Roadmap to achieving sustainable development: Does digital economy matter in industrial green transformation?
Authors: Yang Xiaodong , Xu Yang , Razzaq Asif , Wu Desheng , Cao Jianhong , Ran Qiying 
Published: October 2023

AbstractThe rapid advancements in the digital economy have created numerous opportunities and solutions for industrial green transformation. However, the complex relationship between these two has received relatively less attention. Therefore, this study analyses how the digital economy impacts industrial green transformation across 30 Chinese provinces. The empirical findings highlight the digital economy's significant role in driving industrial green transformation. Within this dynamic framework, two crucial operational mechanisms have been identified: heightened public awareness of environmental issues and the vigorous innovation of green technologies. It becomes evident that the digital economy can energize and sustain the momentum of industrial green transformation. Notably, this influence is most pronounced in eastern‐central China. However, its impact in western China appears relatively weaker, especially at higher quantiles. We observe a strong correlation between the evolution of the digital economy and industrial green transformation in terms of space and time. Higher spatiotemporal regression coefficients are primarily found in areas south of the Hu line, while lower values are more common in the northern regions. These findings provide insights into how the digital economy can be strategically applied to drive industrial green transformation.
Development of a Rapid Gold Nanoflowers Immunochromatographic Test Strip Based on the Nanobody for Detection of Aflatoxin B1
Authors: Pang Jiarui , Ren Wenjie , He Baoshan , Tu Zhui 
Published: October 2023

AbstractA rapid gold nanoflowers (AuNFs) immunochromatographic test strip (ICTS) based on the nanobody (Nb) was developed and used for rapid detection of Aflatoxin B1 (AFB1). Thanks to remarkable physicochemical stability, structural adaptability, ease of genetic manipulation, expression in the prokaryotic system with high yield and tolerance to harsh environments of nanobodies, the G8‐DIG was produced via expression and purification, which was labeled with AuNFs by electrostatic adsorption as signal probes in the ICTS. The AuNFs‐anti‐G8‐DIG nanobodies as a probe of ICTS could specifically recognize not only AFB1 but also DIG‐BSA. In this study, the DIG‐BSA replaced the anti‐6×His‐tag antibody of traditional nanobody‐based ICTS was coated on the control line, which was easier to synthesize, cheaper, and more stable. Under the optimal conditions, the AuNFs‐based nanobody ICTS system accurately detected AFB1 linearly and dynamically over the range (IC20~IC80) of 1.02~27.86 ng/mL, with the IC10 and IC50 of 0.1 ng/mL and 5.46 ng/mL respectively. In addition, these developed nanobodies ICTS had a universal application in the analysis of AFB1 in corn samples.
Unraveling Exchange Coupling in Ferrites Nano‐Heterostructures
Authors: Maltoni Pierfrancesco , Barucca Gianni , Rutkowski Bogdan , Spadaro Maria Chiara , Jönsson Petra E. , Varvaro Gaspare , Yaacoub Nader , De Toro José A. , Peddis Davide , Mathieu Roland 
Published: October 2023

AbstractThe magnetic coupling of a set of SrFe12O19/CoFe2O4 nanocomposites is investigated. Advanced electron microscopy evidences the structural coherence and texture at the interfaces of the nanostructures. The fraction of the lower anisotropy phase (CoFe2O4) is tuned to assess the limits that define magnetically exchange‐coupled interfaces by performing magnetic remanence, first‐order reversal curves (FORCs), and relaxation measurements. By combining these magnetometry techniques and the structural and morphological information from X‐ray diffraction, electron microscopy, and Mössbauer spectrometry, the exchange intergranular interaction is evidenced, and the critical thickness within which coupled interfaces have a uniform reversal unraveled.
Metal‐Organic Framework Derived Bi‐O‐Sn/C Nanostructure: Tailoring the Adsorption Site of Dominant Intermediate for Highly Efficient CO2 Electroreduction to Formate
Authors: Wang Nan , Shao Chunfeng , Zhang Riguang , Zhang Yuan , Min Zhaojun , Chang Bing , Fan Maohong , Wang Jianji 
Published: October 2023

AbstractElectrochemical CO2 reduction into high‐value‐added formic acid/formate is an attractive strategy to mitigate global warming and achieve energy sustainability. However, the adsorption energy of most catalysts for the key intermediate *OCHO is usually weak, and how to rationally optimize the adsorption of *OCHO is challenging. Here, an effective Bi‐Sn bimetallic electrocatalyst (Bi1‐O‐Sn1@C) where a Bi‐O‐Sn bridge‐type nanostructure is constructed with O as an electron bridge is reported. The electronic structure of Sn is precisely tuned by electron transfer from Bi to Sn through O bridge, resulting in the optimal adsorption energy of intermediate *OCHO on the surface of Sn and the enhanced activity for formate production. Thus, the Bi1‐O‐Sn1@C exhibits an excellent Faradaic efficiency (FE) of 97.7% at −1.1 V (vs RHE) for CO2 reduction to formate (HCOO−) and a high current density of 310 mA cm−2 at −1.5 V, which is one of the best results catalyzed by Bi‐ and Sn‐based catalysts reported previously. Impressively, the FE exceeds 93% at a wide potential range from −0.9 to −1.4 V. In‐situ ATR–FTIR, in‐situ Raman, and DFT calculations confirm the unique role of the bridge‐type structure of Bi‐O‐Sn in highly efficient electrocatalytic reduction of CO2 into formate.
In Situ Mapping of Activity Distribution of V(II)/V(III) and Onset Potential Distribution of Hydrogen Evolution Side Reaction in Vanadium Flow Batteries
Authors: Lin Hao , Xu Yang , Chen Xiao , Fang Zengxian , Yan Tian , Ma Kaijie , Liu Le , Xi Jingyu 
Published: October 2023

AbstractVanadium flow batteries (VFBs) face a challenge with the low reaction rates of the V(II)/V(III) redox couple, which limits the performance of VFBs. Additionally, the negative electrode in VFBs is often accompanied by the persistent hydrogen evolution reaction (HER), which is difficult to eliminate. Therefore, understanding the spatial distribution of activity on the negative electrode and the HER side reaction on the electrode surface is of critical importance. This study proposes a weak measurement imaging method to characterize the spatial distribution of surface activity and HER onset potential on the negative electrode in VFBs). This method enables the visualization and in situ detection of key parameters such as the absolute values of |ipa|, |ipc|, |∆E|, |ipc/ipa|, and the HER onset potential. By comparing three different types of graphite felts with varying activity levels, it validates the feasibility of this method. Furthermore, electrochemical stability tests are conducted to study the electrodes repeatability, uniformity, and durability. This method holds promise in guiding the design of electrodes with enhanced activity, good reversibility, minimized HER side reactions, and uniform distribution.