bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review and meta-analysis of the prevalence of alcohol and other drug use and problematic use among people accessing mental health treatment in Australia
Authors: Marel Christina , Siedlecka Ewa , Wilson Jack , Eugene Dit Rochesson Sylvia , Chu Daniel , Fisher Alana , Mills Katherine L 
Published: February 2025

Objective: Substance use and use disorders are elevated among people accessing mental health treatment, but the nature and patterns of use are unknown. The current study aimed to identify the prevalence of alcohol and other drug (AOD) use and problematic AOD use (i.e. hazardous, harmful, risky, misuse, abuse, dependence, disorder) in Australian mental health settings and conduct a meta-analysis of studies where sufficient data were available. Method: A systematic review of all papers published up to July 2023 identified 59 eligible studies reporting the prevalence of substance use, problematic use, and use disorders among people accessing mental health treatment in Australia. Overall, 55 studies provided sufficient data for a meta-analysis for past year use and problematic use of any AOD overall, alcohol, cannabis, tobacco, stimulants/amphetamines, and opioids. Results: Pooled prevalence estimates of past year use and problematic use among clients of mental health treatment settings varied (5%–58% and 7%–53%, respectively). Past year use and past year problematic use of tobacco were particularly prevalent (58% and 53%, respectively), as was cannabis (38% and 37%, respectively). Several key factors, including the type of mental health disorder, may explain some variation in prevalence estimates. Conclusion: The presence of co-occurring and problematic AOD use should be expected among a considerable proportion of clients of mental health treatment settings, and are a significant concern that services must be prepared to address. As such, screening and assessment of AOD use and use disorders should be part of routine clinical care, and clinicians should be familiar with evidence-based management and treatment strategies, including those that address tobacco.
Development of nanocomposites comprising starch and bismuth (III) oxide: An exploration of their viability as substitute materials for shielding high-energy radiation
Authors: Körpınar Berna , Akat Hakan , ÇAM Nebiye Füsun , Canbaz Öztürk Buket 
Published: February 2025

This research focused on investigating the radiation shielding and thermal characteristics of composite materials created by varying the ratios of Bi2O3 and starch. Various composite formulations were developed by blending Bi2O3 powder with starch in ratios of 5%, 10%, 15%, 20%, 25%, 30%, 40%, and 50%. Linear attenuation coefficients of these composites were valued using a NaI(Tl) gamma spectrometry system. Additionally, theoretical calculations were performed using the XCOM platform and GAMOS simulation, incorporating fundamental composite analysis, and these results were compared with empirical data. X-ray diffraction analysis revealed distinct diffraction peaks in Bi2O3 powder, and its pore size distribution exhibited favorable characteristics. Considering the morphological properties of the nanocomposites, it was observed that Bi2O3 in the starch matrix did not undergo agglomeration and even formed homogeneous structures. Examination of the thermal degradation profiles of the samples indicated a significant overlap between the remaining ash quantities and the mass percentages of the prepared samples. The measured experimental linear attenuation coefficient results were ranged from 0.147 ± 0.023 cm−1 to 0.267 ± 0.107 cm−1 for 662 keV, from 0.119 ± 0.007 cm−1 to 0.165 ± 0.021 cm−1 for 1173 keV, and from 0.111 ± 0.015 cm−1 to 0.152 ± 0.040 cm−1 for 1332 keV for starch-Bi2O3 nanocomposites. Notably, the most effective shielding material among the studied samples was found to be a combination of starch and 50% Bi2O3.
Effects of Pattern-Reversal Visual Stimulation on Brain Activity in Migraineurs and General Population
Authors: Shirahige Lívia , Nogueira Fernanda , Melo Lorena , Ungureanu Ruxandra , Rocha Sérgio , Brito Rodrigo , Mendonça Thyciane , de Farias Abelardo , Rodrigues de Araújo Maria das Graças , Piscitelli Daniele , Monte-Silva Kátia 
Published: February 2025

Background A better understanding of migraine pathophysiology through standardized methods could facilitate the development of more effective therapeutic approaches for migraine sufferers. However, neurophysiological studies with migraine sufferers present larger variability, as most contain only a single measurement. Objective This observational study aimed to compare the cortical and visual excitability of migraine sufferers, individuals with other types of headaches, and healthy participants in response to pattern-reversal visual stimulation. Methods Fifty-nine individuals were classified by a neurologist into the following groups: (i) migraineurs (n = 25); (ii) other types of headaches (n = 23); (iii) healthy (n = 11). Habituation during pattern-reversal visual stimulation was assessed by visual evoked potentials. Visual and motor cortex excitability were evaluated before and after pattern-reversal visual stimulation. Results We found no intergroup differences in motor and visual excitability measures after pattern-reversal visual stimulation. Compared to the healthy group, migraineurs and individuals with other types of headaches displayed a reduction in phosphene threshold after pattern-reversal visual stimulation. Additionally, an increase in visual cortical excitability in these groups was also observed. Lastly, the habituation in individuals with migraines and other types of headaches was lower compared to healthy individuals. Therefore, the lack of habituation may not be exclusively associated with the pathophysiological mechanisms of migraine. Conclusion Individuals who experience headaches, including migraineurs, have an increased visual cortical excitability in response to visual stimuli. This finding is promising for guiding future neurophysiological research to identify cortical biomarkers in migraineurs and in other types of headaches.
Distinctive cerebral small vessel disease patterns are associated with ischemic stroke in systemic lupus erythematosus
Authors: Silva Guilherme D , Vieira Germana T , Rimkus Carolina de M , Neves Yuki Emily F , Azevedo Raymundo S , Tinone Gisela , Pereira Rosa MR , Conforto Adriana B 
Published: February 2025

Background Systemic lupus erythematosus (SLE) increases the risk of ischemic stroke (IS) and cerebral small vessel disease (CSVD) through a unique interplay of cardiovascular and immune-mediated mechanisms. There is an unmet need of predictors of IS risk and of characterization of the distinctive features of CSVD in patients with SLE. Objectives To assess if CSVD is more extensive in patients with SLE and ischemic stroke (IS+) than in those without (IS-); to identify distinctive neuroimaging features of CSVD in patients with SLE. Methods This observational study, conducted at an academic referral center in São Paulo, Brazil, included SLE patients who underwent brain MRI between 2010 and 2021. Two neuroradiologists, blinded to clinical data, reached a consensus on the summary CSVD score, that consists of microbleeds, lacunes of presumed vascular origin, enlarged perivascular spaces, and white matter hyperintensities of presumed vascular origin. Logistic regression was performed with IS as the dependent variable. Results We included 106 patients, 53 IS+ and 53 IS- (median age: 41; interquartile range, 34;51 years; 92% women). The summary CSVD score was independently associated with the IS + group (OR 3.83, 95% CI 1.73 – 9.87, p = 0.002), even after adjusting for age, hypertension, secondary antiphospholipid syndrome, and use of antimalarial drugs. Microbleeds predominated in cortical regions (23/24, 92%), lacunes in the basal ganglia (10/16, 63%) and white matter hyperintensities in the deep white matter (47/59, 80%). Conclusion CSVD was more frequent in IS+ than in IS-, highlighting the need for prospective studies in SLE to test CSVD as a biomarker of IS risk. Microbleeds predominated in the cortical region, different from reports of age-related and hypertension-associated CSVD.
Homelessness and First-Episode Psychosis: An Integrative Review
Authors: Lewczyk Jessica 
Published: February 2025

Background: About 115,000 young people in the United States experience a first episode of psychosis (FEP) annually. FEP is associated with functional decline and long-term executive functioning impairment. Schizophrenia is a risk factor for homelessness with up to 20% of individuals diagnosed experiencing homelessness. Homelessness conveys many burdens including higher rates of victimization, incarceration, and substance use. The intersection of homelessness and FEP represents a uniquely vulnerable population undergoing the compounding effects of two highly stigmatizing burdensome experiences that negatively impact health outcomes, treatment engagement, and life expectancy. Aims: This study reviews the literature to explore what is currently known about the impacts of homelessness on individuals with FEP, knowledge gaps, directions for research, and recommendations for action. Methods: An integrative review was conducted in April 2023 with APAPsychInfo, APAPsychArticle, Medline, and CINAHL. Results: This is the first known review to examine available literature on homelessness and FEP. Current literature examines aspects of FEP and homelessness, but not the likely compounding and interacting relationships between multiple variables. Although the associations among variables such as FEP, homelessness, substance use, legal involvement, family involvement, and treatment engagement have not been studied, the literature available may be suggestive of a compounding negative effect on FEP outcomes. Conclusion: FEP programs should define homelessness, report rates of homelessness, and conduct research examining the compounding effects of homelessness and FEP as well as other factors like race and ethnicity. Research and policy should support housing interventions for homeless individuals to improve treatment engagement and health outcomes.
Concurrent Tumor-Treating Fields and Chemoradiotherapy: Outcomes in Grade 4 Glioma Patients
Authors: Li Jintan , Tao Jincheng , Lu Hongyu , Fan Xiao , Wang Zhichao , Wang Yingyi , Wang Xiefeng , Yan Wei , You Yongping , Cao Yuandong , Zhang Junxia 
Published: February 2025

Background: Surgical intervention, complemented by radiotherapy and chemotherapy with temozolomide, constitutes the conventional treatment protocol for patients with newly diagnosed grade 4 glioma. We have conducted a research to evaluate the efficacy and safety of an integrated treatment regimen that incorporates tumor-treating fields with concurrent chemoradiotherapy. Methods: This retrospective research analyzed the clinical data of 39 adults who were newly diagnosed with World Health Organization (WHO) grade 4 gliomas at the First Affiliated Hospital of Nanjing Medical University, between February 2022 and April 2023. Each participant received a concurrent treatment regimen consisting of temozolomide (75 mg/m2 daily), tumor-treating fields (200 kHz), and brain irradiation (60 Gy delivered in 30 fractions). Maintenance treatment comprised ongoing temozolomide and tumor-treating fields. Adverse events were documented in accordance with the Common Terminology Criteria for Adverse Events version 5.0 (CTCAE 5.0) and specific grading criteria for dermatological adverse events associated with tumor-treating fields. Results: Among the 39 enrolled patients, disease progression was observed in 22 individuals (56.4%), with a median progression-free survival (PFS) of 14.2 months (95% confidence interval [CI]: 13.1-14.3 months). The median overall survival (OS) was 18.2 months (95% CI: 17.3 months to not reached). Patients diagnosed with glioblastoma had a median PFS of 13.1 months (95% CI: 12.9-14.2 months) and a median OS of 18.2 months (95% CI: 17.3 months to not reached). In contrast, patients diagnosed with astrocytoma had a median PFS of 14.3 months (95% CI: 12.8 months to not reached) and a median OS of 17.0 months (95% CI: 10.6 months to not reached). Twenty-five patients (64.1%) experienced dermatological adverse events, and 30 (77.0%) experienced mild hematological adverse reactions related to chemoradiotherapy. Conclusion: The application of tumor-treating fields concurrent with post-surgery chemoradiotherapy is both safe and effective for treating patients with newly diagnosed WHO grade 4 gliomas, exhibiting only limited toxicity.
20 years since Section 28: An examination of the non-mandatory status of LGBT curricular inclusion in English primary schools
Authors: Lecuyer Arabeth 
Published: February 2025

Over 20 years have passed since the repeal of Section 28, the UK government’s legislation banning any teaching which could be seen to ‘promote homosexuality’. Within these two decades, there have been significant legislative shifts concerning equality in education. And yet, national policy still frames LGBT content in the curriculum as an exception. In the current Relationships Education (RE) guidance, primary schools are still able to decide whether it is appropriate to include LGBT content in their teaching and must consult with parents on the content of the RE curriculum. This article looks at the RE curriculum, alongside interview and questionnaire data from primary teachers and school workers, to understand how it represents both change and continuity from the past of Section 28. The findings of this article suggest that though some schools did include LGBT content in RE, the allowances for absenting LGBT content, and the requirements to consult with parents, have allowed for its continued absence in many schools.
Experimental investigation and analytical modeling of shear behavior at UHPC-NC interfaces in wet joints of precast assembly piers
Authors: Yin Shujun , Zhou Mi , Zhao Xiaonan , Ma Lei 
Published: February 2025

This study investigates the shear properties of ultrahigh performance concrete (UHPC) wet joints through direct shear tests on UHPC flat joint specimens. Four sets of specimens were designed with varying levels of constrained normal stress. The results showed that all specimens exhibited brittle shear damage near the UHPC-NC interface. The application of 1 MPa, 2 MPa and 3 MPa constrained normal stress increased the shear strength by 103.4%, 184.4%, and 272.3%, respectively, compared to the unconstrained specimen. An analytical model is proposed to quantitatively describe the shear stress-slip behavior of the UHPC-NC interface under various levels of constrained normal stress, accompanied by a calculation formula for its characteristic points. The model links normal stress, stiffness, roughness, and defines shear curve descent., allowing for reliable prediction of the shear stress-slip relationship of the UHPC-NC interface. Furthermore, a validated finite element model using ABAQUS software was developed, which aligned with analytical results and further strengthened the reliability of the proposed model. The results suggest that the shear strength of the UHPC-NC interface can be enhanced by adjusting the constrained normal stress, given its high sensitivity as an impact factor. The shear bearing capacity can be described using the proposed model, which consists of a linear ascending segment, a peak point, and a declining damage segment with an exponential evolution pattern, with a recommended damage index parameter of 4.68.
Multicenter study of HPC coated p48 and p64 flow diverters for treatment of intracranial aneurysms under dual antiplatelet therapy
Authors: Goertz Lukas , Weyland Charlotte S , Nikoubashman Omid , Bürkle Franziska , de Beukelaer Frederic , Siebert Eberhard , Gronemann Christian , Hohenstatt Sophia , Dorn Franziska , Bohner Georg , Wiesmann Martin , Ridwan Hani , Kabbasch Christoph 
Published: February 2025

Objective Phenox flow diverters (p64 and its smaller vessel variant p48) represent an established treatment option for intracranial aneurysms. This study evaluates the safety and efficacy of the new generation of these devices with an additional antithrombotic surface coating (HPC). Methods Consecutive patients treated between 2020 and 2023 at three institutions were retrospectively reviewed for aneurysm characteristics, procedural details, complications, and angiographic outcomes. Results Sixty-one patients (mean age 56 years) were treated for 61 aneurysms. The mean aneurysm size was 8.3 ± 4.9 mm, 12 (19.7%) were ruptured, 16 (26.2%) were recurrent after previous treatment, 10 (16.4%) were located in the posterior circulation, and 7 (11.5%) had nonsaccular morphology. All procedures were technically successful, with a single device sufficient in 60/61 (98%) cases. Delivery problems included device twisting in one case and incomplete proximal opening in another. Additional angioplasty was performed in 3/61 (4.9%) procedures and additional coiling in 4 (6.6%). There were 3 (4.9%) major events (1 thromboembolic ischemic stroke, 1 fatal intracranial hemorrhage, and 1 delayed aneurysm rupture) and 6 (9.8%) minor strokes. Follow up at a mean of 6 months showed complete occlusion in 33/42 (79%) aneurysms, neck remnants in 5 (12%), and aneurysm remnants in 4 (10%). Conclusions The results demonstrate comparable acceptable complication rates and angiographic results of the Phenox HPC, which are similar to other flow diverters. Long-term and comparative studies are needed to evaluate the full potential of these devices.
Data processing of whole process cost management in building engineering based on AI
Authors: Yu Sujing 
Published: February 2025

Current housing construction projects are facing challenges such as cost overruns. Traditional cost forecasting methods can no longer meet the needs of the construction industry under digital transformation. This paper aims to explore a new cost forecasting method to improve forecasting accuracy and efficiency. This paper introduces the PSO-BP algorithm, which optimizes the weights and thresholds of BPNN to enhance the forecasting performance. The study selected 15 groups of housing construction project data with similar basic parameters as samples. After data cleaning, the BP neural network (BPNN) was used for cost prediction. To further improve the prediction effect, the particle swarm optimization (PSO) algorithm is introduced to form the PSO-BP algorithm to optimize the weights and thresholds of BPNN. Research results show that the PSO-BP algorithm performs better than BPNN in cost prediction. Specifically, when predicting the cost of Project 1, the error of BPNN is 7.67 yuan/square meter, while the error of the PSO-BP algorithm is only 2.12 yuan/square meter. In addition, when predicting the risks of 8 projects, the maximum error of BPNN is 0.18 points, while the maximum error of the PSO-BP algorithm is only 0.04 points. The results show that the PSO-BP algorithm not only improves the accuracy of cost forecasting but also significantly improves the efficiency and accuracy of risk assessment, helping to formulate more scientific cost control plans.
Issues and trends in generative AI technologies for decision making
Authors: Phillips-Wren Gloria , Virvou Maria 
Published: February 2025

Generative AI (GenAI) technologies are examined through the lens of issues and trends related to decision making. After examining the foundations of the technology particularly related to large language models (LLM), opportunities for GenAI to be used in the decision-making process of intelligence, design, choice and implementation are explored. With its ability to rapidly generate insights, present optimized solutions, and provide detailed analysis of given input, the technology has demonstrated that it can assist and augment human decision making. Although GenAI systems have the potential to transform content creation and human cognition, they also raise issues around accuracy, misinformation, ethics, bias, morality, social impacts, privacy, copyright, legality, and explainability, among others. Addressing these challenges is important to maximize the efficacy of GenAI in decision making.
The impact of motor, non-motor, and social aspects on the sexual health of women living with Parkinson's disease
Authors: Nóbrega Kátia Cirilo Costa , Nascimento Isaíra Almeida Pereira da Silva , Souza Bruno Rafael Antunes , Gonçalves Raíssa Amorim , Martins Thalyta Silva , Santos Geovanna Ferreira , Silva Bruno Eron de Almeida da , Helene Frazão André , Roque Antônio Carlos , Savica Rodolfo , Pimentel Piemonte Maria Elisa 
Published: February 2025

Background Sexual health is influenced by a complex interplay of biological, psychological, and social factors, all of which can be impacted by Parkinson's disease (PD). Female sexual dysfunction includes reduced sexual desire and/or arousal, pain during sexual activity, or difficulty achieving orgasm. Despite its impact on quality of life, sexual health in women with PD remains poorly understood. Objective To investigate the impact of motor, non-motor, and social PD aspects on sexual health of women with PD. Methods We conducted a cross-sectional study with 100 women with PD (Hoehn and Yahr stages 1–3) who reported an active sex life in the last six months. Data were collected via remote interviews and included demographic and clinical features, cognitive capacity, motor and non-motor experiences, fatigue, self-esteem, sleep disorders, couple relationship quality, depressive symptoms, and sexual health assessments using the Female Sexual Function Index (FSFI) and Sexual Quotient-Female (SQ-F). Multiple regression models were used to identify predictors of FSFI and SQ-F scores. Results Results indicated that while several motor, non-motor, and social factors correlated with sexual health, only couple relationship quality and sleep quality significantly predicted both short-term (FSFI) and long-term (SQ-F) sexual health. No significant associations were observed with age, disease onset, postmenopausal status, or daily medication dosage. Conclusions The present study's evidence identifies multiple key areas, such as couple's relationship quality and sleep quality that could be targeted for intervention to improve sexual health in women with PD.