bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anxious‐depressive attack and rejection sensitivity—Toward a new approach to treatment‐resistant depression
Authors: Kaiya Hisanobu 
Published: December 2023

AbstractThis paper aimed to find clues to treatment‐resistant depression (TRD) solutions. Depression comorbid with anxiety is often treatment‐resistant where anxious‐depressive attack (ADA) often lurks. ADA is a recently proposed clinical idea for just a psychological version of a panic attack. It mostly begins with an abrupt surge of intense anxiety followed by uninterrupted intrusive thoughts; lasting ruminations about regret or worry produced by violent anxiety, agitation, and loneliness. Acting‐out behaviors such as deliberate self‐injury and over‐dose may also be observed during the attack. As the basic psychopathology of ADA, rejection sensitivity (RS) was revealed by a structural equation model. It is said that the presence of RS in depressive disorders implies a poor prognosis. The following biological markers for RS were reviewed in the literature: first, the involvement of the μ‐opioid receptor function in RS and, secondly, hypersensitivity of the dopamine D4 receptor (DRD4) in the medial prefrontal cortex. The latter has been suggested in fear‐conditioned animal experiments. Manipulation of the μ‐opioid receptor function together with the DRD4 function may culminate in a treatment for RS, which could contribute to the development of a treatment for TRD via the improvement of ADA.
Robust performance for composites using silicone rubber with different prospects for wearable electronics
Authors: Kumar Vineet , Alam Md. Najib , Yewale Manesh A. , Park Sang‐Shin 
Published: December 2023

AbstractThe different configurations of the composites originated with machine or human motion, and their mechanical stability for wearable electronics is in focus. Here, the study highlights that these configurations are critical for wearable devices. To achieve these aspects, the electroactive and dielectric silicone rubber (SR) was used as a host matrix. This SR not only provides flexibility, twisting, or stretchability for such devices, but its lightweight makes them comfortable for robust wearable devices. The reinforcing fillers such as graphite nanoplatelets (GNP) or diatomaceous earth (DE) and their hybrids are used. The electromechanical properties of the device were performed using the universal testing machine. The output voltage generated at 15 phr filler was 0.3 mV (GNP), 0.15 mV (DE), and 0.22 mV (hybrid). Similarly, the biomechanical properties were studied with human motion joints such as thumb pressing or wrist bending. The output voltage at 15 phr was best for thumb pressing and it was 0.42 mV (GNP), 0.18 mV (DE), and 0.25 mV (hybrid). In the same way, the mechanical aspects studied in this work are compressive modulus, tensile strength, and fracture strain. For example, the compressive modulus was 1.28 MPa (control) and increased at 15 phr filler to 2.44 MPa (GNP), 3.2 MPa (DE), and 2.75 MPa (hybrid). Similarly, the mechanical stretchability of the devices was 134% (control) and changed at 15 phr filler to 128% (GNP), 78% (DE), and 109% (hybrid). Overall, the work demonstrates the method to develop a device with high mechanical, electromechanical, and biomechanical properties and their usefulness for wearable electronic devices.
Chemical surface modification for RO membranes based on GO‐mixed polymers for water desalination and biofouling study
Authors: Shalaby Marwa S. , Abdallah Heba , Wilken Ralph , Christoph Schmuser , Shaban Ahmed M. , Mansor Eman 
Published: December 2023

AbstractThe modification of conventional polyamide reverse osmosis (RO) membranes with grafted methacrylic acid in the presence of nanomaterial is disclosed. To decrease fouling, this study shows the effectiveness of grafting a hydrophilic methacrylic acid (PMAA) and graphene oxide (GO) nanosheet. The change in membrane surface after coating method with different layers was obvious. The results of the ATR‐FTIR, SEM, AFM, contact angle investigations from side and enhanced rejection and permeability from other side proved that the grafting and modification processes had been successful. In comparison between different modifications based on grafting for thin film and blend RO membranes (RO T, RO P, and RO PG), it was found that the modified membrane nominated RO TG membranes showed less biofouling. The modified membrane with 1.25 weight percent PMAA concentration and 0.4 weight percent distributed GO had the lowest contact angle, the least fouling, the highest chlorine resistance, and improved desalination performance.Highlights
Biofouling study for modified RO membranes
Chlorine resistance membranes for water desalination
Enhanced surface hydrophilicity through grafting of polyamide membranes
Analytical modeling and experimental estimation of the dynamic mechanical characteristics of green composite: Caesalpinia decapetala seed reinforcement
Authors: Chenrayan Venkatesh , Kanaginahal Gangadhar , Shahapurkar Kiran , Soudagar Manzoore Elahi M. , Fouad Yasser , Kalam M. A. 
Published: December 2023

AbstractThe emerging need for a sustainable environment prompts the research community to develop functional materials with bio‐ and organic waste. This research advocates biodegradable waste management and its performance evaluation. The involvement of Caesalpinia decapetala (CD) as a potential reinforcement in the epoxy matrix and its analytical evaluation of thermal stability are novel ideas for disposing of bio and organic waste. Three different variants (10, 20, and 30 wt%) of CD seed particles are used to develop the epoxy composite, and further, their influence on dynamic mechanical characteristics such as damping type, loss modulus, and storage modulus has been investigated. The results corroborate that the higher CD seed content (30 wt%) in the epoxy matrix enhances the storage modulus, loss modulus, and damping on a scale of 1.14, 1.25, and 1.07 times that of the neat epoxy matrix. The reason behind the improved dynamic properties has been validated through theoretical modeling. A substantial increment in the degree of entanglement and activation energy in the band of 8.33 × 10−3 moles/m3 and 20.201 kJ/mol, respectively, in comparison with neat epoxy, is considered to be good authentication for the thermal stability of the CD 30 specimen. The analytical prediction of storage modulus is executed with five different models, whereas damping behavior is executed with two different models. The analytically estimated results are matched with the experimental ones, and we conclude that they are in fair agreement with the experimental findings.
Characterization of outer membrane vesicles released by clinical isolates of Neisseria gonorrhoeae
Authors: Dhital Subhash , Deo Pankaj , Stuart Isabella , Huang Cheng , Zavan Lauren , Han Mei‐Ling , Kaparakis‐Liaskos Maria , Ramm Georg , Schittenhelm Ralf B. , Howden Benjamin , Naderer Thomas 
Published: December 2023

AbstractThe sexually transmitted pathogen Neisseria gonorrhoeae releases membrane vesicles including outer membrane vesicles (OMVs) during infections. OMVs traffic outer membrane molecules, such as the porin PorB and lipo‐oligosaccharide (LOS), into host innate immune cells, eliciting programmed cell death pathways, and inflammation. Little is known, however, about the proteome and LOS content of OMVs released by clinical strains isolated from different infection sites, and whether these vesicles similarly activate immune responses. Here, we characterized OMVs from four N. gonorrhoeae isolates and determined their size, abundance, proteome, LOS content, and activation of inflammatory responses in macrophages. The overall proteome of the OMVs was conserved between the four different isolates, which included major outer membrane and periplasm proteins. Despite this, we observed differences in the rate of OMV biogenesis and the relative abundance of membrane proteins and LOS. Consequently, OMVs from clinical isolates induced varying rates of macrophage cell death and the secretion of interleukin‐1 family members, such as IL‐1α and IL‐1β. Overall, these findings demonstrate that clinical isolates of N. gonorrhoeae utilize membrane vesicles to release proteins and lipids, which affects innate immune responses.
3,5‐difluoro‐2,4,6‐trinitrophenol: A high‐energy compound born under the “NO2FNO2” construction strategy
Authors: Zhu Jin , Li Cong , Jing Suming , Yang Lei , Liu Yucun , Zhang Wei , Zhang Jun 
Published: December 2023

Abstract3,5‐Difluoro‐2,4,6‐trinitrophenol (DFTNP) was designed as energetic compounds, based on the “NO2FNO2” strategy. Its structure was fully characterized by IR, NMR, elemental analysis, and single‐crystal X‐ray diffraction. Physico‐chemical characterization of this compound was investigated based on several theoretical techniques. The result indicated that DFTNP is less sensitive to external stimuli, with a thermal sensitivity of 213 °C, impact and friction sensitivity of 15 J and 240 N. It also shows particularly high density (ρ=1.949 g cm−3) and detonation performance (D=8440 m s−1, P=32.60 GPa), which far exceeds the performance of picric acid. Its crystal packing and the intermolecular interaction of DFTNP play an important role inreducing localized heating. In addition, this compound also has great potential for building ionic salts, and its ammonium salt performance exhibits better performance. Good performance not only highlight this compound as a suitable replacement for picric acid, but also suggests that “NO2FNO2” may be a good choice in designing energetic compounds.
Identification and characterization of the metabolites of sinomenine using liquid chromatography combined with benchtop Orbitrap mass spectrometry and nuclear magnetic resonance spectroscopy
Authors: Fang Ke , Ren Shaoyu , Zhang Qian 
Published: December 2023

RationaleSinomenine, a major bioactive compound isolated from Sinomenium acutum, has been used for the treatment of rheumatoid arthritis and other cardio‐cerebrovacular diseases. However, the metabolism of this drug has not been fully investigated. The current work was carried out to investigate the in vitro metabolism of sinomenine in liver microsomes.MethodsThe metabolites were generated by incubating sinomenine (3 μM) with the liver microsomes in the presence of NADPH at 37°C. The structure of the metabolites was characterized using liquid chromatography coupled to high‐resolution mass spectrometry (HRMS). Two major metabolites synthesized and their structures were further confirmed using nuclear magnetic resonance spectroscopy.ResultsUnder the current conditions, 12 metabolites were found and structurally identified using high resolution MS and MS2 spectra. Among these metabolites, M1, M2, M3, M4, M5, M6, M7, M9, M11, and M12 were first reported. The metabolites M8 and M10 were synthesized and unambiguously identified as N‐desmethyl‐sinomenine and sinomenine N‐oxide, respectively. The phenotyping study revealed that the formation of M8 was catalyzed by CYP2C8, 2C19, 2D6, and 3A4, whereas the formation of M3, M6, and M10 were exclusively catalyzed by CYP3A4. The metabolic pathways of sinomenine include N‐demethylation, O‐demethylation, dehydrogenation, oxygenation, and N‐oxygenation.ConclusionsN‐Demethylation and N‐oxygenation were the primary metabolic pathways of sinomenine. This study provides new insight into the in vitro metabolism of sinomenine, which would help prospects of sinomenine disposition and safety assessments.
Successful Treatment of Ulceration in Hidradenitis Suppurativa with Topical Bucladesine: A Case Report
Authors: Kurokawa Ichiro , Kita Kanako , Hashimoto Takashi 
Published: December 2023

Abstract
We report a case of hidradenitis suppurativa (HS) with skin ulceration in a 19-year-old man. He was successfully treated with topical bucladesine ointment treatment, resulting in a hypertrophic scar 2 months after the treatment. Bucladesine can be an alternative treatment option for ulceration in HS.
Synergy of Front‐Surface Energy‐Level Gradient and Lattice Anchoring Effect for Enhancing Perovskite Solar Cell Performance
Authors: Guo Mingxuan , Pang Huimin , Chen Xingtong , Wan Peng , Xia Xueqing , Chen Song 
Published: December 2023

AbstractA front surface gradient of the absorber valence band can effectively reduce the open‐circuit voltage (VOC) loss of perovskite solar cells by suppressing the minority carrier concentration near the front surface. However, the existing method is limited to the one‐step fabrication process, resulting in underachieved photon harvesting and power conversion efficiency (PCE). To solve the problem, ZnCd‐based alloy quantum dots (QDs) are utilized to create a valence‐band‐maximum gradient at the front surface of a two‐step processed FAPbI3 absorber. This design significantly enhances VOC without requiring surface passivation. Furthermore, it is demonstrated that reducing the QD‐perovskite lattice mismatch while maintaining QD's energy levels mitigates nonradiative recombination without compromising the front surface gradient effect. As a result, normal‐structured perovskite solar cells achieve a VOC equivalent to 93% of the Schockley–Queisser limit and a PCE of 24.37%.
Regulation of Glucose Metabolism for Cell Energy Supply In Situ via High‐Energy Intermediate Fructose Hydrogels
Authors: Lu Bolun , Zhao Qiuyu , Cai Zhengwei , Qian Shutong , Mao Jiayi , Zhang Liucheng , Mao Xiyuan , Sun Xiaoming , Cui Wenguo , Zhang Yuguang 
Published: December 2023

AbstractThe cellular functions, such as tissue‐rebuilding ability, can be directly affected by the metabolism of cells. Moreover, the glucose metabolism is one of the most important processes of the metabolism. However, glucose cannot be efficiently converted into energy in cells under ischemia hypoxia conditions. In this study, a high‐energy intermediate fructose hydrogel (HIFH) is developed by the dynamic coordination between sulfhydryl‐functionalized bovine serum albumin (BSA‐SH), the high‐energy intermediate in glucose metabolism (fructose‐1,6‐bisphosphate, FBP), and copper ion (Cu2+). This hydrogel system is injectable, self–healing, and biocompatible, which can intracellularly convert energy with high efficacy by regulating the glucose metabolism in situ. Additionally, the HIFH can greatly boost cell antioxidant capacity and increase adenosine triphosphate (ATP) in the ischemia anoxic milieu by roughly 1.3 times, improving cell survival, proliferation and physiological functions in vitro. Furthermore, the ischemic skin tissue model is established in rats. The HIFH can speed up the healing of damaged tissue by promoting angiogenesis, lowering reactive oxygen species (ROS), and eventually expanding the healing area of the damaged tissue by roughly 1.4 times in vivo. Therefore, the HIFH can provide an impressive perspective on efficient in situ cell energy supply of damaged tissue.
Supramolecular Ionogels for Use in Locating Damage to Underwater Infrastructure
Authors: Jia Liangying , Xiao Jing , Tan Yu , Zhang Kaiqiang , Liu Yaqing , Wang Xu 
Published: December 2023

AbstractThe capacity to self‐detect and locate damage to underwater infrastructure in emergencies is vital, as materials and technologies that securely facilitate energy and information transmission are crucial in several fields. Herein, the development of a multifunctional supramolecular ionogel (SIG) and SIG‐based devices for use in detecting and locating damage to underwater infrastructure is reported. The SIG is fabricated via the single‐step photoinitiated copolymerization of hydroxy and fluorinated monomers in a fluorinated ionic liquid. Hydrogen‐bond/ion‐dipole‐interaction synergy ensures that the SIG is highly ionically conductive and extremely mechanically strong, with underwater self‐healing and adhesion properties. It can be used as an underwater ionic cable to provide reporting signals via changes in strain; furthermore, SIG‐based devices can be fixed to underwater infrastructure to locate damage via resistance monitoring. The SIG can also be attached to the human body for use in underwater communication, thereby safeguarding maintenance personnel while repairing underwater infrastructure. This study provides a novel pathway for developing supramolecular materials and devices.
Myco‐remediation of selenium contaminated environment and future prospects: An overview
Authors: Siddharthan Seema , Thangaraj Sheela , Paulraj Sobanadevi , RajaMohmed Beemashafreen , Rakkamuthu KrishnaPriya , Dharmaraj Vithya , Renganathan Madura , Umadevi Pongiya 
Published: December 2023

AbstractSelenium is a trace element which is an essential micronutrient for all organisms. Though it is essential, if taken in excess leads to toxicity. Hence have a detrimental effect on the health. Selenium exists in various oxidation states out of which selenite and selenate are toxic and forms the major part of the pollutant in the ecosystem. Therefore, there is an urgent need to address this issue in an eco‐friendly, efficient, and substantial way to protect the environment from further deterioration. In this regard, fungi have developed unique metabolic pathways to nullify the toxic effects of these pollutants and the process is known as mycoremediation. Mycoremediation is a cost‐effective, environmentally friendly, and efficient approach of environmental remediation that addresses organic, inorganic, and developing toxins (such as antibiotics and pharmaceuticals) by using fungus or their components. An alternative, environmentally friendly method for cleaning up contaminants in environmental matrices is provided by mycoremediation. This is due to the fact that most organic toxins are broken down rather than removed, which lowers the possibility of pollutants entering the food chain through bioaccumulation. Fungi possess robust morphology and various catabolic enzymes capable of using pollutant as a growth substrate. They transform the toxic selenium species via a series of biochemical reaction such as oxidation, reduction, methylation, and demethylation into nontoxic elemental selenium and selenium nanoparticles. Mycoremediation is a process subset that employs to fungi to degrade and restore contaminated Eco‐System. For this reason, a potential framework of “mycoremediation” was proposed to make it easier for this promising to report global environmental issues.
A superconvergent CDG finite element for the Poisson equation on polytopal meshes
Authors: Ye Xiu , Zhang Shangyou 
Published: December 2023

AbstractA conforming discontinuous Galerkin (CDG) finite element is constructed for solving second order elliptic equations on polygonal and polyhedral meshes. The numerical trace on the edge between two elements is no longer the average of two discontinuous Pk functions on the two sides, but a lifted function from four Pk functions. When the numerical gradient space is the subspace of piecewise polynomials on subtriangles/subtehrahedra of a polygon/polyhedron which have a one‐piece polynomial divergence on , this CDG method has a superconvergence of order two above the optimal order. Due to the superconvergence, we define a post‐process which lifts a Pk CDG solution to a quasi‐optimal solution on each element. Numerical examples in 2D and 3D are computed and the results confirm the theory.
Extraction and Visually Driven Analysis of VGI for Understanding People’s Behavior in Relation to Multifaceted Context
Authors: Burghardt Dirk , Dunkel Alexander , Hauthal Eva , Shirato Gota , Andrienko Natalia , Andrienko Gennady , Hartmann Maximilian , Purves Ross 
Published: December 2023

AbstractVolunteered Geographic Information in the form of actively and passively generated spatial content offers great potential to study people’s activities, emotional perceptions, and mobility behavior. Realizing this potential requires methods which take into account the specific properties of such data, for example, its heterogeneity, subjectivity, and spatial resolution but also temporal relevance and bias.The aim of the chapter is to show how insights into human behavior can be gained from location-based social media and movement data using visual analysis methods. A conceptual behavioral model is introduced that summarizes people’s reactions under the influence of one or more events. In addition, influencing factors are described using a context model, which makes it possible to analyze visitation and mobility patterns with regard to spatial, temporal, and thematic-attribute changes. Selected generic methods are presented, such as extended time curves and the co-bridge metaphor to perform comparative analysis along time axes. Furthermore, it is shown that emojis can be used as contextual indicants to analyze sentiment and emotions in relation to events and locations.Application-oriented workflows are presented for activity analysis in the field of urban and landscape planning. It is shown how location-based social media can be used to obtain information about landscape objects that are collectively perceived as valuable and worth preserving. The mobility behavior of people is analyzed using the example of multivariate time series from football data. Therefore, topic modeling and pattern analyzes were utilized to identify average positions and area of movements of the football teams.
Digital Volunteers in Disaster Management
Authors: Fathi Ramian , Fiedrich Frank 
Published: December 2023

AbstractDuring disaster situations, social media is used extensively by the affected population for communication and collaboration, but there is also increased public sharing of important disaster-related information about the current situation. With the goal of utilizing this data and Volunteered Geographic Information (VGI) for disaster management, digital volunteers organized themselves into so-called Volunteer and Technical Communities (V&TC). In addition, professionalized digital volunteers have institutionalized Virtual Operations Support Teams (VOST) in established Emergency Management Agencies (EMA). While technical issues have dominated research in this area in recent years, questions about the motivation, organization, and impact of the analytical work of these volunteers have remained unanswered. In this chapter, we present five studies that address questions about the motivation of digital volunteers, organization, and collaboration requirements, the analytical impact of VOST, data biases in Crisis Information Management (CIM), and privacy-related topics. Overall, it could be shown that digital volunteers make a significant contribution during disaster management, in which they effectively process their analytical results and VGI for the management of disaster situations. However, human limitations and privacy-related methods need to receive greater attention in the future, both in research and in practice.