bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Short-Term Intensity Change in Tropical Cyclones Using a Convolutional Neural Network
Authors: Griffin Sarah M. , Wimmers Anthony , Velden Christopher S. 
Published: November 2023

Abstract
This study details a two-method, machine learning approach to predict current and short-term intensity change in global tropical cyclones (TCs), “D-MINT” and “D-PRINT.” D-MINT and D-PRINT use infrared imagery and environmental scalar predictors, while D-MINT also employs microwave imagery. Results show that current TC intensity estimates from D-MINT and D-PRINT are more skillful than three established intensity estimation methods routinely used by operational forecasters for North Atlantic and eastern and western North Pacific TCs. Short-term intensity predictions are validated against five operational deterministic guidances at 6-, 12-, 18-, and 24-h lead times. D-MINT and D-PRINT are less skillful than NHC and consensus TC intensity predictions in North Atlantic and eastern North Pacific TCs, but are more skillful than the other guidances for at least half of the lead times. In western North Pacific, north Indian Ocean, and Southern Hemisphere TCs, D-MINT is more skillful than the JTWC and other individual TC intensity forecasts for over half of the lead times. When probabilistically predicting TC rapid intensification (RI), D-MINT is more skillful in North Atlantic and western North Pacific TCs than three operationally used RI guidances, but less skillful for yes–no RI forecasts. In addition, this work demonstrates the importance of microwave imagery, as D-MINT is more skillful than D-PRINT. Since D-MINT and D-PRINT are convolutional neural network models interrogating two-dimensional structures within TC satellite imagery, this study also demonstrates that those features can yield better short-term predictions than existing scalar statistics of satellite imagery in operational models. Finally, a diagnostics tool is revealed to aid the attribution of the D-MINT/D-PRINT intensity predictions.

Significance Statement
This study develops a method to predict current and short-term forecasts of tropical cyclone (TC) intensity using artificial intelligence. The resultant models use a convolutional neural network (CNN) that can identify two-dimensional features in satellite imagery that are indicative of TC intensity and future intensity change. The performance results indicate that in several TC basins, the CNN approach is generally more skillful than alternative satellite-based estimates of TC intensity as well as operational short-term forecasts of deterministic intensity change and of similar skill to probabilistic rapid intensification forecasts.
Urban Heat Island Vulnerability in the City of Recife, Pernambuco, Brazil
Authors: Moreira Ayobami Badiru , Nóbrega Ranyére Silva , Wanderley Lucas Suassuna de A. , Matzarakis Andreas 
Published: November 2023

Abstract
This study introduces the urban heat island vulnerability index (UHIVI) for Recife, Brazil, the center of the most populated metropolitan area in the Northeast region. The index, encompassing sensitivity, adaptive capacity, and exposure, integrates demographic data through factor analysis to derive a social vulnerability index (SVI). Urban heat island (UHI) intensity data addresses exposure, enabling a comprehensive analysis of both the physical and social dimensions of the city. Results reveal heightened UHI exposure in the city center and coastal areas, correlating with higher urbanization density. However, populations in most areas of these regions demonstrated higher adaptive capacities, translating to lower UHI vulnerability. Conversely, less-discussed areas in traditional UHI approaches, with limited adaptive capacity and heightened sensitivity, emerge, shedding light on previously overlooked urban vulnerabilities. Regions near the city center featuring irregular settlements prove most susceptible to UHI. Illiteracy, aging demographics, and local environmental conditions emerge as the three main factors contributing to UHIVI. The index’s application unveils spatial complexities and inequalities, offering urban planners a nuanced understanding of the city. This comprehensive insight aids in policy development and decision-making, empowering planners to address urban disparities effectively. The UHIVI thus emerges as a valuable tool for understanding the challenges of urban planning, fostering more resilient and equitable urban development.
An Observational Study Quantifying the Disproportionate Impact of COVID-19 Among Immigrant Adults, 2021 California Health Interview Survey
Authors: Siddiq Hafifa , Teklehaimanot Senait , Williams James 
Published: November 2023

Objective: Substantial data on COVID-19–related morbidity and mortality among medically underserved populations are available, yet data on the social impact of the COVID-19 pandemic among immigrants in the United States are limited. We identified COVID-19–related health and social disparities among US immigrants. Methods: We analyzed predictors of COVID-19–related health and social outcomes (including ever had or thought had COVID-19, vaccine uptake, risk-reduction behaviors, job loss, childcare difficulties, and difficulty paying rent) during the pandemic by citizenship status, using data from the 2021 California Health Interview Survey. The overall sample size included 24 453 US-born citizens, naturalized citizens, and noncitizens aged ≥18 years. We examined relationships between sociodemographic variables, including immigration-related factors, and COVID-19–related health and social outcomes using descriptive, bivariate, and multivariate logistic regression analysis. Results: When accounting for sociodemographic characteristics, noncitizens had higher odds than naturalized and US-born citizens of experiencing challenges during the COVID-19 pandemic, including difficulty paying rent (adjusted odds ratio [aOR] = 1.54; 95% CI, 1.47-2.42) and job loss (aOR = 1.43; 95%, CI, 1.14-1.79). At the bivariate level, noncitizens had the highest rate of ever had or thought had COVID-19 (24.7%) compared with US-born citizens (20.8%) and naturalized citizens (16.8%; all P < .001). Noncitizens also had a significantly higher likelihood of risk-reduction behaviors (eg, always wearing a face covering, getting vaccinated if available) than US-born citizens ( P < .001). Conclusion: These findings reveal the disproportionate impact of the COVID-19 pandemic among noncitizens and reflect limited socioeconomic resources, limited access to health care, and precarious employment among noncitizens in California during the pandemic. Citizenship status should be considered a critical immigration-related factor when examining disparities among immigrant populations.
Application of diffusional kurtosis imaging for insights into structurally aberrant topology in Parkinson's disease
Authors: Zhu Siying , Wang Lijuan , Lv Xiang , Xu Yao , Dou Weiqiang , Zhang Hongying , Ye Jing 
Published: November 2023

Background Parkinson's disease (PD) has been regarded as a disconnection syndrome with functional and structural disturbances. However, as the anatomic determinants, the structural disconnections in PD have yet to be fully elucidated. Purpose To non-invasively construct structural networks based on microstructural complexity and to further investigate their potential topological abnormalities in PD given the technical superiority of diffusion kurtosis imaging (DKI) to the quantification of microstructure. Material and Methods The microstructural data of gray matter in both the PD group and the healthy control (HC) group were acquired using DKI. The structural networks were constructed at the group level by a covariation approach, followed by the calculation of topological properties based on graph theory and statistical comparisons between groups. Results A total of 51 patients with PD and 50 HCs were enrolled. Individuals were matched between groups with respect to demographic characteristics ( P >0.05). The constructed structural networks in both the PD and HC groups featured small-world properties. In comparison with the HC group, the PD group exhibited significantly altered global properties, with higher normalized characteristic path lengths, clustering coefficients, local efficiency values, and characteristic path lengths and lower global efﬁciency values ( P <0.05). In terms of nodal centralities, extensive nodal disruptions were observed in patients with PD ( P <0.05); these disruptions were mainly distributed in the sensorimotor network, default mode network, frontal-parietal network, visual network, and subcortical network. Conclusion These findings contribute to the technical application of DKI and the elucidation of disconnection syndrome in PD.
Effects of Renin–Angiotensin System Inhibitors on Atrial Mechanics Parameters in Patients with Metabolic Syndrome
Authors: Peraza-Zaldivar Juan A. , Ponce-Guarneros Juan M. , Cardona-Muñoz Ernesto G. , Esparza-Guerrero Yussef , Saldaña-Cruz Ana M. , González-Vazquez Sergio A. , Gonzalez-Lopez Laura , Gamez-Nava Jorge I. , Rodriguez-Jimenez Norma A. 
Published: November 2023

Introduction Metabolic syndrome (MS) is associated with abnormalities in atrial mechanics, atrial remodeling, and an increased risk of heart rhythm disorders. One of the most commonly used approaches to the prevention of cardiac remodeling in arterial hypertension is the administration of renin–angiotensin system (RAS) inhibitors. Therefore, this study aimed to investigate the effects of RAS inhibitors on atrial mechanics parameters in patients with MS. Methods and materials This longitudinal observational study included 55 patients with hypertension and MS, as defined by the ATP III criteria. The patients were evaluated at the start of antihypertensive treatment with an RAS inhibitor. The patients’ clinical characteristics, chosen pharmacological treatment, and transthoracic echocardiography findings were recorded at baseline and 6 months thereafter. A student's dependent sample t-test was used for comparisons between groups. Pearson correlation was used to evaluate the relationships between variables. Results Patients with MS had higher peak atrial longitudinal strain (PALS) values at 6 months than at baseline. Meanwhile, systolic strain and peak late strain rates were lower at follow-up than at baseline. The different antihypertensive treatments had comparable effects on the PALS changes during the follow-up period. Higher high-density lipoprotein levels at baseline were correlated with changes in PALS. Conclusion The administration of RAS inhibitors improved atrial mechanics parameters in the early stages of antihypertensive management in MS.
Pyometra alters the redox status and expression of estrogen and progesterone receptors in the uterus of domestic cats
Authors: Nascimento Acácia Eduarda de Jesus , Santos Luciano Cardoso , Santos Bianca Reis , Santos Emilly Oliveira , Cunha Maria Clara da Silva Galrão , Snoeck Paola Pereira das Neves , de Lavor Mário Sérgio Lima , Silva Juneo Freitas 
Published: November 2023

Objectives The aim of this study was to evaluate the expression profile of sex steroid receptors and redox mediators in the uterus of domestic cats with pyometra. Methods Twelve cats were used and divided into groups: (1) non-gestational healthy diestrus (n = 7) and (2) pyometra (n = 5). The plasma profiles of estradiol and progesterone (P4) as well as uterine expression levels of estradiol alpha (ERα), progesterone (PR) and androgen (AR) receptors, of the antioxidant enzymes superoxide dismutase 1 (SOD1), catalase and glutathione peroxidase 1 (GPX1), and of the oxidative damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) were evaluated. Results Cats with pyometra showed higher plasma P4 levels and increased uterine messenger RNA (mRNA) and protein expression of ERα and PR, mainly in the glandular epithelium for ERα and in stromal and myometrial cells for PR. In addition, there was an increase in 8-OHdG immunostaining and GPX1 mRNA and protein expression in cats with pyometra compared with those in non-gestational diestrus, while catalase showed a reduction in endometrial immunostaining in cats with pyometra. There were no differences in uterine AR and SOD1 expression between the groups. Conclusion and relevance The findings of this study showed that pyometra is associated with oxidative stress in the uterus of domestic cats and alterations of the profile of sex steroid receptors, especially ERα and PR, and of antioxidant enzymes, suggesting that changes in these mediators may play a role with the etiopathogenesis of this disease.
Untrained Bystanders Administering Drone-Delivered Naloxone: An Exploratory Study
Authors: Adams Nicole , Kong Nan , Tian Renran , Altidor Christelle , Chang Shen 
Published: November 2023

Introduction: Opioid overdose deaths continue to climb in the United States. Administering naloxone to an overdose victim can save their life, but rapid access to naloxone remains a barrier. Delivering naloxone to a bystander using a drone has potential to increase naloxone availability but there are still many uncertainties about this mode of delivery. Can an untrained bystander to an opioid overdose successfully administer drone delivered naloxone after viewing video instructions on the drone and how long does it take? Methods: This mixed-methods observational study, conducted in a controlled outdoor environment, simulated an opioid overdose using a mannequin (overdose victim) and panicked bystander. Untrained and medically naïve participants were instructed to call for help, move the drone from the landing spot to the mannequin, and follow the instructions provided by the drone to administer naloxone. Data was collected using video recordings, interviews, and an online survey. Time stamp data was extracted from the video for 2 time points: time for removing the naloxone from the drone and time to administer the naloxone. Interviews were audio recorded and analyzed using an inductive concept analysis approach. One interview question was coded as a binary response of anxiety/no anxiety and added to the demographic data. Results: The average time to remove and administer naloxone was 62 seconds. Anxiety during the activity was reported by 59% of the participants but there was no correlation between anxiety and time. The design of our drone and instructional video can be improved. Conclusions: We have established baseline times for completing steps in administering naloxone delivered by drone. We were able to successfully induce anxiety and have a baseline measure for what percentage of untrained bystanders may experience anxiety when involved with an emergency situation. Design of instructional materials and drone construction can contribute to anxiety and successful administration of naloxone.
Recovering Individuals’ Feelings About Addict and Alcoholic as Stigmatized Terms: Implications for Treatment
Authors: Hassett-Walker Connie 
Published: November 2023

Background: The current emphasis among addiction treatment providers is to use person-first language, such as “a person with a substance use disorder,” as a way to reduce stigma around addiction and resulting barriers to treatment. This study considers how individuals recovering from substance use feel about the terms “alcoholic” and “addict,” particularly how they self-identify and whether they believe the terms carry stigma. Method: Thirty-five individuals were interviewed, recruited primarily, but not exclusively, from 12-step meetings (Alcoholics Anonymous, Narcotics Anonymous), from 3 locations throughout a rural New England state. Interviews were transcribed and coded in Atlas Ti qualitative analysis software, and a content analysis of text coded with “stigma” was conducted. Results: Some comments reflected a belief that the terms “addict” and “alcoholic” carry a stigma. However, more comments rejected the notion of these being stigmatized terms; or acknowledged the stigma but reflected the subject’s lack of internalizing of any stigma. Comments reflected other themes including a sense of pride, identity and ownership when self-identifying as an addict or alcoholic. Several comments suggested that person-first language is part of a larger movement to “soften everything,” without changing the underlying condition (addiction). The findings may reflect the fact that subjects were recruited from 12-step programs, where the convention is to self-identity using the terms “alcoholic” and/or “addict.” Conclusions: Some individuals seeking treatment for addiction may prefer self-identifying using old-school terminology (addict, alcoholic) rather than person-first language, for a variety of reasons (eg, they do not internalize the stigma of such terms).
Clinical Pathological Characteristics and Prognosis of Multigene Co-Mutations in Elderly Patients With Non-Small Cell Lung Cancer: A Retrospective Analysis
Authors: Li Wanjing , Chang Fangqun , Zhang Hao , Meng Furong , Ke Zhangyan , Zhang Yanbei 
Published: November 2023

Background: With the development and wide application of next-generation sequencing (NGS), multiple-gene mutations related to lung cancer are detected using this technology. Notably, even multigene concomitant mutations (co-mutations), which occur at a relatively low incidence, can be detected more effectively using NGS. It is well-known that the percentages of non-small cell lung cancer (NSCLC) in the elderly lung cancer population are also gradually increasing, while its prognosis is hard and the quality of long-term survival is poor. This study aimed at investigating the common clinicopathologic features of multigene co-mutations for better evaluating the prognosis of elderly NSCLC patients. Methods: A total of 464 NSCLC patients were divided into 3 groups according to the types of gene mutation, whose clinical data were retrospectively analyzed. Results: In total, 38.36% (178/464) of NSCLC patients were in the nonmutation group, 50% in the single-gene mutation group, and 11.64% in the multigene co-mutation group. Nonmutation, single-gene mutation, and co-mutation groups were all prone to occur in male adenocarcinoma patients ( P < .05). EGFR gene mutation rates were the highest in the single-gene mutation and co-mutation groups (54.31% and 24.35%). In the co-mutation group, the incidence of EGFR/PIK3CA, LK/KRAS, and EGFR/MET co-mutations was the highest (16.67%, 11.11%, and 7.41%). ALK/HER2/MET, EGFR/HER2/MET, and EGFR/HER2/MET/ROS1 multiple-gene co-mutations were, respectively, found in 1 case, and the multigene co-mutation patients commonly had a worse median progression-free survival (PFS) than that of single-gene mutation (7.13 vs 12.34 months, P = .013). Conclusion: With the application of NGS, the detectable rates of gene co-mutation are increasingly high in elderly patients with NSCLC, which mainly occurs in male adenocarcinoma patients commonly with poor PFS. It will be critically necessary to conduct multigene detections by NGS for directing targeted therapy of elderly NSCLC patients.
Disease progression in the first 5 years of treatment in multiple sclerosis: Predictive value of early brain and lesion volume changes
Authors: Mattiesing Rozemarijn M , Kramer Eline , Strijbis Eva MM , Brouwer Iman , van Schijndel Ronald A , Gentile Giordano , Battaglini Marco , De Stefano Nicola , Uitdehaag Bernard MJ , Barkhof Frederik , Vrenken Hugo , Schoonheim Menno M 
Published: November 2023

Background: Whether the degree of inflammation (and its resolution) and neurodegeneration after treatment initiation predicts disease progression in multiple sclerosis (MS) remains unclear. Objectives: To assess the predictive value of magnetic resonance imaging (MRI)-derived brain and lesion volume (LV) changes in years 1 and 2 of treatment for disease progression. Methods: Patients receiving early interferon beta-1a treatment in REFLEX/REFLEXION ( N = 262) were included. Predictive regression models included new/enlarging LV (positive activity), disappearing/shrinking LV (negative activity), and global/central atrophy during years 1 and 2. Results: Faster global atrophy and/or pseudo-atrophy and positive lesion activity in years 1 and 2 related to an increased probability and faster conversion to clinically definite multiple sclerosis (CDMS). Negative lesion activity in year 1 and slower central atrophy in year 2 were predictive of confirmed disability progression (9-Hole Peg Test). Positive lesion activity in year 2 was predictive of faster global atrophy, while positive lesion activity in years 1 and 2 was predictive of faster central atrophy. Conclusions: A higher degree of global atrophy and/or pseudo-atrophy in year 1 was predictive of CDMS. Positive lesion activity in any year was related to CDMS and neurodegeneration. Disability was related to negative lesion activity in year 1 and slower central atrophy in year 2.
Three-Year Safety and Efficacy of the INCRAFT Endograft for Treatment of Abdominal Aortic Aneurysms: Results of the INSIGHT Study
Authors: Torsello Giovanni , Bertoglio Luca , Kellersmann Richard , Wever Jan J. , van Overhagen Hans , Stavroulakis Konstantinos 
Published: November 2023

Purpose: Preliminary results of the INSIGHT study showed that the low-profile INCRAFT Abdominal Aortic Aneurysm (AAA) Stent-Graft System was safe and effective in the endovascular aneurysm repair (EVAR). This study aimed to assess the durability and the midterm effectiveness of EVAR using the INCRAFT System in the framework of a multicenter, prospective, open-label, post-approval study. Materials and Methods: Between 2015 and 2016, 150 subjects from 23 European centers treated with the INCRAFT System for an infrarenal AAA were included. Clinical and radiologic data were prospectively collected and analyzed using protocol-specified, monitored follow-up clinic visits at 1, 6, and 12 months post-implantation and annually after that. The clinical success at 3 years was determined. Freedom from overall and aneurysm-related mortality, type I endoleak, secondary interventions, and aneurysm sac enlargement through 3 years were evaluated. Kaplan-Meier estimates were used for late outcomes. An independent clinical events committee reviewed all events. The CT (computed tomography) scans through 1 year were reviewed by an independent core laboratory. Results: The primary clinical success rate at 3 years was 84.0% (126/150). There were no aneurysm-related deaths, endograft migration, or aneurysm-related ruptures through 3 years. Stent fracture was detected in 2 subjects (1.3%) without clinical sequelae. Over 3 years, freedom from overall mortality was 89.4%, freedom from secondary interventions was 80%, and freedom from aneurysm sac enlargement was 96.5%. The 3-year freedom from type IA and IB endoleaks was 93.3% and 98.6%, respectively. Conclusions. In a multicenter real-world study setting, the use of a low-profile INCRAFT device for AAA is associated with sustained clinical success and low rates of reinterventions through 3 years. Clinical Impact Low-profile endografts have broadened the spectrum of patients with anatomic suitability for endovascular repair of abdominal aortic aneurysms (AAA). However, questions remain regarding the durability of the repair. The INSIGHT study evaluated the use of the INCRAFT System in routine real-world clinical practice, including patients with complex anatomies. The treatment was safe and effective. The results showed sustained clinical success over 3 years, with no aneurysm-related deaths or ruptures, and a high rate of intervention-free survival at 3 years. Despite the low-profile design of the endograft, the midterm results demonstrate the durability of AAA repair using the INCRAFT System. ClinicalTrials.gov Identifier: NCT02477111.