bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sagittal Alignment in the Degenerative Lumbar Spine
Authors: Diebo Bassel G. , Balmaceno-Criss Mariah , Lafage Renaud , McDonald Christopher L. , Alsoof Daniel , Halayqeh Sereen , DiSilvestro Kevin J. , Kuris Eren O. , Lafage Virginie , Daniels Alan H. 
Published: January 2024

➤ Sagittal alignment of the spine has gained attention in the field of spinal deformity surgery for decades. However, emerging data support the importance of restoring segmental lumbar lordosis and lumbar spinal shape according to the pelvic morphology when surgically addressing degenerative lumbar pathologies such as degenerative disc disease and spondylolisthesis.➤ The distribution of caudal lordosis (L4-S1) and cranial lordosis (L1-L4) as a percentage of global lordosis varies by pelvic incidence (PI), with cephalad lordosis increasing its contribution to total lordosis as PI increases.➤ Spinal fusion may lead to iatrogenic deformity if performed without attention to lordosis magnitude and location in the lumbar spine.➤ A solid foundation of knowledge with regard to optimal spinal sagittal alignment is beneficial when performing lumbar spinal surgery, and thoughtful planning and execution of lumbar fusions with a focus on alignment may improve patient outcomes.
Profunda Femoris Pseudoaneurysm and Fatal Hemorrhage 2 Weeks After Modified Girdlestone Resection Arthroplasty
Authors: Pasquinelly Adam , Andrews Kyle 
Published: January 2024

Case:
A 62-year-old nonambulatory female patient presented with wound dehiscence and purulent bloody drainage 2 weeks after modified Girdlestone resection arthroplasty for subtrochanteric femur fracture. On developing an enlarging thigh hematoma and hemodynamic instability, the patient was taken to the vascular suite where a profunda femoris artery pseudoaneurysm was identified and ligated by the vascular surgery team. The proximal free edge of the resected femur was determined to be the likely cause of arterial injury. Two days later, the patient was taken by the orthopaedic surgery team for debridement and revision resection arthroplasty, but she ultimately decompensated and died.

Conclusion:
We believe this to be the first reported case of this serious complication of the Girdlestone procedure. We hope this case helps bring awareness to the complication and aids in early detection and prompt treatment of femoral artery complications.
Treatment of an Impending Pathologic Sacral Fracture with a Novel Iliosacral Fusion Construct
Authors: Jacobs Robert C. , Polly David W. 
Published: January 2024

Case:
A 49-year-old woman presented with left leg radiculopathy and posterior pelvic pain. Subsequent evaluation demonstrated metastatic multiple myeloma with an impending left S1 sacral fracture. Immediate posterior pelvic ring stabilization was recommended to prevent fracture and disruption of her oncologic recovery. This was performed percutaneously with computer-assisted navigation using a novel cannulated screw design.

Conclusion:
The patient was treated with prophylactic percutaneous posterior pelvic ring fixation with a novel cannulated screw design that provided a durable construct for immediate weight-bearing. The fixation prevented a pathologic fracture and allowed immediate return to activity.
Contribution of meat-free days, meat-free meals, and portion sizes to declines in meat consumption in the UK
Authors: Vonderschmidt Alexander , Bellows Alexandra , Jaacks Lindsay , Alexander Peter , Green Rosemary , Stewart Cristina 
Published: January 2024

Abstract

Understanding behaviours driving recent declines in UK meat consumption is essential for achieving the Climate Change Committee’s 20% reduction target by 2030. This study explored trends in meat-eating days, daily meat-eating meal occasions, and portion size of meat from the National Diet and Nutrition Survey (2008/09-2018/19). Meat consumption was assessed using 4-day food diaries. Trends were assessed with Poisson and linear regression models, while decomposition analysis quantified relative contributions to overall reductions. Meat-eating days decreased from 3.27 (0.04) to 3.03 (0.05) (P < 0.001), daily occasions decreased from 1.24 (0.02) to 1.13 (0.03) (P = 0.01), and portion size decreased from 85.8g (1.85) to 76.1g (1.78) (P < 0.001). Reduction in portion size had the largest impact on total meat consumption (57%), followed by days (37%) and occasions (6%). Our findings suggest smaller meat portions significantly contributed to decreasing UK meat consumption. Dissecting these behaviours can inform interventions to reduce meat consumption, aligning with reduction targets.
Lentilactobacillus farraginis FSI (3): A whole cell biocatalyst for the synthesis of kojic acid derivative under aquatic condition
Authors: Chaudhari Mangal , Wankhede Pratiksha , Dalal Kiran , Kale Arun , Dalal Dipak , Chaudhari Bhushan Liladhar 
Published: January 2024

Abstract

Kojic acid derivatives are useful in the cosmetics and pharmaceutical industries. The current investigation focuses on the search for a safe and environment-friendly newer whole-cell biocatalyst for the synthesis of kojic acid derivative especially 2-amino-6-(hydroxymethyl)-8-oxo-4-phenyl-4,8-dihydropyrano[3,2-b] pyran-3-carbonitrile (APhCN). In this context, a total of six cultures were isolated from fecal samples of infants and subjected to probiotic characterization followed by screening as whole cell biocatalyst (WCB). In this multicomponent reaction, benzaldehyde, malononitrile, and kojic acid were used to synthesize APhCN at room temperature under aqueous conditions. The screening of potent whole cell biocatalyst (WCB) from isolated cultures was done by comparing reaction time and percent yield. The potent WCB gave a good yield of 95% within 15 h of time and hence further characterized biochemically and identified as LentiLactobacillus farraginis by using 16S rRNA gene sequencing. Lactobacilli having GRAS (generally regarded as safe) status and being able to carry out this transformation under moderate reaction conditions with easy recovery of both product and biocatalyst, it has the potential to replace some of the chemical catalytic methods.
Dental cements as a late-stage peri-implant complication: A microtomographic and histopathological study in a rat model
Authors: Chandrashekar Bhuvana Lakkasetter , Biguetti Claudia C. , Arteaga Alexandra , Miramontes Andres J. , Rios Evelin , Rodrigues Danieli C. 
Published: January 2024

Abstract

Cement mediated peri-implantitis accounts for 1.9–75% of dental implant failures associated with peri-implant diseases. This study evaluated the biological impact of dental cements on osseointegrated implants using Lewis rats. Twenty-two rats were distributed into 6 groups: negative control (NC), soft diet (SD), and hard diet (HD); positive control SD and HD (n = 3); Implant + bio-ceramic Cement (BC) SD and HD which included contralateral Sham sites (n = 5). Titanium implants were placed on either side of the maxillae and allowed to heal for 14 days. Later, both sides of experimental groups underwent a re-entry surgery to simulate clinical cementation. The right side received 0.60mg of BC. At 14 days post cement application, maxillae were harvested for clinical, microtomographic, and histological evaluations. Clinical and microtomographic evaluations indicated evidence of extensive inflammation and circumferential bone resorption around BC implants in comparison to NC. Histology revealed cement particles surrounded by inflammatory infiltrate in the implant area accompanied by biofilm for SD groups. Both sides of BC indicated intensive bone resorption accompanied by signs of osteolysis when compared to NC. Cemented groups depicted significantly lower bone to implant contact when compared to NC. In conclusion, residual cement extravasation negatively impacts osseointegrated implants after re-entry surgeries.
Proteomic profiling of Arabidopsis nuclei reveals distinct protein accumulation kinetics upon heat stress
Authors: Saez-Vasquez Julio , Muñoz-Diaz Eduardo , Fuenzalida-Valdivia Isabel , Darriere Tommy , Anne DeBures , Blanco-Herrera Francisca , Rompais Magali , Carapito Christine 
Published: January 2024

Abstract

Heat stress (HS) impacts the nuclear proteome and, subsequently, protein activities in different nuclear compartments. In Arabidopsis thaliana, a short exposure to 37°C leads to loss of the standard tripartite architecture of the nucleolus, the most prominent nuclear substructure, and, consequently, affects the assembly of ribosomes. Here, we report a quantitative label-free LC‒MS/MS (Liquid Chromatography coupled to tandem Mass Spectrometry) analysis to determine the nuclear proteome of Arabidopsis at 22°C, HS (37°C for 4 and 24 hours), and a recovery phase. This analysis identified ten distinct groups of proteins based on relative abundance changes in the nucleus before, during and after HS: Early, Late, Transient, Early Persistent, Late Persistent, Recovery, Early-Like, Late-Like, Transient-Like and Continuous Groups (EG, LG, TG, EPG, LPG, RG, ELG, LLG, TLG and CG, respectively). Interestingly, the RNA Pol I subunit NRPA3 and other main nucleolar proteins, including Nucleolin and Fibrillarin, were detected in RG and CG, suggesting that plants require increased nucleolar activity and likely ribosome assembly to restore protein synthesis after HS.
Recent Investigation of Characterizing, quantifying, and Contamination of Microplastic in the surface water of Adyar River Estuary, Tamil Nadu, India
Authors: M Velmurugan P. , Vijayaprabhakaran Krishnan , P.T Devika , S Venkatesan , Meer Mohammad Suhail , M Rajesh Kumar , M Kavisri 
Published: January 2024

Abstract

In the current scenario, microplastics are an ever-increasing contaminant that poses an environmental hazard to the surface water environment. The foremost objective of current research is to examine the identity, characterizing, spatial distribution throughout, and abundance of microplastics in the Adyar River estuary. Microplastics have been found in the estuary's water samples utilizing the NOAA approach. Polymers such as polyethylene (52%), polypropylene (32%), and polystyrene (16%) were often identified in all water sampling sites. Surface water (total microplastic items = 82; total sampling site = 12) was found to be contaminated with 1–9 items/site of various kinds of microplastics. Colorless (17.0%), white (15.0%), black (29.0%), green (11.0%), blue (13.0%), and red (15.0%) microplastics were found in the estuary's water of Adyar River. To investigate the characteristics of microplastics, analytical techniques such as FTIR and microplastics identified by stereo microscopy (SM) were utilized. The largest part frequent types of microplastic to be discovered in the surface water of estuary are fibers (39.0%), fragments (27.0%), films (16.0%), foam (11.0%), and pebbles (7.0%). This research represents a basis for a study on the microplastic pollution of the Adyar River estuary in Tamil Nadu, India.
Glomerular Filtration Rate and Urolithiasis: Results from the UK Biobank
Authors: Wang Yue , Shan Ying , Liu Beini , Yin Fang , Dai Liang , Shi Yixuan , Shi Jianqing , Xiong Zuying , Cai Renjiao , Wu Yan , Zhe Xingwei , Liang Wei 
Published: January 2024

Abstract
Introduction:
To investigate the association of a decreased estimated glomerular filtration rate (eGFR) with urolithiasis risk. This study aimed to investigate the association between eGFR and the risk of urolithiasis formation in the general population.
Methods
This is a prospective cohort study. We included 426,866 community-dwelling participants (39 to 73 years old) from the UK Biobank. Participants joined the study from 2006 to 2010 and were followed up until 2021. We used the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula based on cystatin C to calculate eGFR. Cox proportional hazards regression models were used to evaluate the association between eGFR and the risk of urolithiasis formation.
Results
The mean age of all participants was 56 years, of which 231,509 were female (54%) and 403,214 (94%) were White. During a mean follow-up of 12.4 years, 5,176 participants (1%) developed incident urolithiasis. We found that participants were 3% (adjusted hazard ratio [HR] 1.03, 95% confidence interval [CI] 1.01–1.06, p = 0.01) more likely to develop urolithiasis for every 10 mL/min/1.73 m2 decrease in eGFR. Compared to those with eGFR between 90–104 mL/min/1.73 m2, the HRs (95% CIs) for the eGFR < 60, 60 ≤ eGFR < 75, 75 ≤ eGFR < 89 and eGFR ≥ 105 mL/min/1.73 m2 groups were 1.19 (1.02–1.38), 1.07 (0,96–1.18), 1.02 (0.94–1.11), and 0.93 (0.83–1.04), respectively.
Conclusion
A lower eGFR is associated with higher risk of urolithiasis formation in the general population.
Integrating clinico-pathological features and longitudinal liquid biopsy results to predict clinical benefit from immune checkpoint Inhibitors in advanced Non-Small Cell Lung Cancer patients
Authors: Bragadin Andrea Boscolo , Bianco Paola Del , Zulato Elisabetta , Attili Ilaria , Pavan Alberto , Carlet Jessica , Marra Ludovica , Guarneri Valentina , Indraccolo Stefano , Bonanno Laura 
Published: January 2024

Abstract

Background: Immune checkpoint inhibitors (ICIs) are widely used in non-oncogene addicted Non-small cell lung cancer and characterized by high heterogeneity in clinical benefit. Different combination strategies are available in first-line setting and PD-L1 is the only predictive marker used in clinical practice.
Methods: Patients with NSCLC treated with ICI single-agent according to clinical practice were prospectively enrolled. Liquid biopsy was performed at the time of first dose administration (T1), after 3 weeks (T2) and at the time of radiological evaluation (T3). Cell free DNA (cfDNA) was quantified (ng/ml) by qPCR and analysed by NGS targeted panel.
Molecular variables used for association with outcome endpoints were: cfDNA quantification as static parameter, dynamic cfDNA change (DT2-T1), variant allele frequency of the gene with the highest frequency at base line (MaxVAF) and dynamic maxVAF change (DT2-T1). Cox regression analysis was used to build integrated predictive models.
Results: 113 patients were included. At multivariate analysis, PD-L1 negativity, T1 cfDNA, cfDNA increase (DT2-T1), and maxVAF at T2 were significantly associated with shorter PFS; PD-L1 negativity, squamous histology, T1 cfDNA, increase of cfDNA (DT2-T1), and maxVAF at T2 were significantly associated with worse OS. Integrated model permitted to build a nomogram and establish three groups of patients deriving different clinical benefit from ICI. The model was tested in patients expressing PD-L1 ³50% and treated with first-line pembrolizumab (n=57) and was able to identify elevated maxVAF at T2 and increase (DT2-T1) of cfDNA as independently associated with worse PFS; higher levels of maxVAF at T2 and increase (DT2-T1) of cfDNA with worse OS. Derived integrated model was able to identify patients with different clinical benefit (high, intermediate, low risk).
Conclusions: We developed an integrated nomogram to stratify NSCLC patients deriving different clinical benefit from ICIs which outperforms individual predictive markers.
Reaction, Reactivity and Behaviour of α-Chloroacetamides in the Synthesis of Acrylamide Derivatives
Authors: Ishak Esam. A. , Mousa Sayed A. S. , Bakheet Momtaz E. M , Abu-Shanab Fathi A. 
Published: January 2024

Abstract
In this research, we synthesized unexpected dithiol of ether derivatives (5a-e) by the reaction of α-chloroacetamides (1a-e), carbon disulfide in the presence of sodium isopropoxide in the corresponding alcohol. We expected this reaction to produce 3,6-bis-dimercaptomethylene-1,4-di-substituted-piperazine-2,5-dione (3a-g) in one pot reaction, but, surprisingly, this reaction afforded the dithiol derivatives (5a-e). The structures of the products were elucidated by 1H NMR, 13C NMR, IR, mass spectroscopic data, and elemental analyses. Also, the postulated reaction mechanism provides an explanation of this result and effective the presence of carbon disulfide in the reaction, where the refluxing of compounds (1a-e) in the presence of sodium isopropoxide in the isopropanol afforded piperazine derivatives by intermolecular condensation [1], and then we repeat this reaction by using methoxide, ethoxide, and isopropoxide in the corresponding alcohol we found the same results.
A numerical study on the energy barrier for cutting magnetic stripe domains in thin films
Authors: Moon Kyoung-Woong , Yang Seungmo , Kim Changsoo , Ju Tae-Seong , Hwang Chanyong 
Published: January 2024

Abstract

A magnetic skyrmion has drawn a lot of interest due to its use in spintronics applications. For skyrmion studies, it is important to find the samples from which skyrmions can be made. The stripe state consists of elongated up and down domains and is often considered a precursor to skyrmion states; attempts have been made to turn the stripe state into a skyrmion state. However, not all stripe states convert to skyrmion states, which is particularly difficult with wide stripes. Here, we show that the energy barrier that separates the stripe state from the skyrmion state has an approximate universal trend concerning stripe width. These results provide a basic understanding for the difficulty encountered in making skyrmions on wide stripe states. However, with this energy barrier in consideration, the stability of the skyrmion state can be improved.
Correlation of blood pressure changes following postural change from sitting to standing with near infrared spectroscopy (NIRS)
Authors: Shali Roya Kheyrkhah , Setarehdan Seyed Kamaledin , Seifi Behjat 
Published: January 2024

Abstract
Sudden changes in the body position, e.g., sitting to standing, usually cause brain blood pressure to drop. This may disturb one’s balance especially in the elderly people. Also, maintaining balance after standing up is a vital issue for elderly and anyone suffering from nervous system disorders. As the body command center it is important to study and monitor brain hemodynamics after ones changes his/her position from sitting to standing. There are different modalities to study brain function in such scenarios among them functional near infrared spectroscopy (fNIRS) is chosen in this research due to the system simplicity, safety and less impact of motion artifacts. In this research, we aim to find the relationship of NIRS signal with the changes in blood pressure caused by changing the position from sitting to standing. For this purpose, fNIRS signals were recorded in 20 healthy young people during sit to stand position using a two-channel fNIRS system. In the same time an automatic sphygmomanometer is used to measure their blood pressure while sitting at rest, before standing up, immediately after standing up, and in rest standing. As a result, correlation values of 0.68 and 0.69 were obtained between the systolic blood pressure and the HbO2 signal recorded from the short channel and the THb signal recorded from long channel respectively.
Does Childhood Poverty Affect Health Conditions in the Adulthood? Evidence from a Longitudinal Survey in Bangladesh
Authors: Islam Md. Deen , Azad Abul Kalam 
Published: January 2024

Abstract
Background
Childhood poverty can intensely influence a child's physical, emotional, and cognitive development, eventually impacting their physical and mental well-being in adulthood. This study delves into the repercussions of childhood poverty on health consequences during adulthood.
Methods
This study investigates the enduring impact of childhood poverty on adult health status using longitudinal data from the Mahabub Hossain Panel Data in Bangladesh spanning over three decades. Employing an Ordered Logit Model, the research examines the relationship between childhood poverty, individual and household characteristics, and health outcomes in their adult time period.
Results
Utilizing extensive longitudinal data, the research reveals that exposure to poverty during childhood has enduring effects on health well into adulthood. The findings reveal a significant negative association between childhood poverty and adult health status, persisting even after adjusting for various individual factors. However, when household characteristics are considered, the significance of childhood poverty diminishes, indicating the mediating role of the household environment in shaping health outcomes. Policy implications emphasize the need for early childhood interventions, income support, mental health services, housing and neighborhood improvements, and strategies promoting income mobility.
Conclusion
Overall, the study underscores the urgency of targeted public health measures to break the cycle of poverty-related health disparities and promote equitable health outcomes across the life course.
The platform business model selection of online ride-hailing giants based on the aggregation model
Authors: Xueyu ZHU , GUO Min , LI Jinhong 
Published: January 2024

Abstract

Pure self-management model, pure aggregation business model and Self-support + aggregation model are three commonly used business modes on ride-hailing platforms. We use an analytical model to study these three business models and give the optimal business model decision of the platform. The research shows that the heterogeneity ratio of drivers, the cost of the platform under the Self-support model, the franchise fee received by the platform under the aggregation model and the dissatisfaction of the original users on the platform play a key role in the selection of the platform's business model. When the difference between the franchise fee under the aggregation mode and the platform cost under the Self-support mode fails to generate positive feedback on the platform profit, the platform should choose the pure Self-support mode. When riders are more sensitive to the heterogeneity of service quality of the platform and user stickiness can be ensured, the platform should choose the pure aggregation business model. When user stickiness can be guaranteed and the cost of the platform under the self-run model is controllable, the platform should choose the Self-support + aggregation business model.
Genetic Evidence Supporting Causal Roles of EIF4 family in breast cancer: A Two-Sample Randomized Mendelian Study
Authors: Shi Jin-Yu , Wen Rui , Chen Jin-Yi , Feng Yi-Qian , Zhang Yuan-Yuan , Hou Si-Jia , Xi Yu-Jia , Wang Jiang-Fen , Zhang Ya-Fen 
Published: January 2024

Abstract
Background: Translational control plays a crucial role in the regulation of apoptosis, with the EIF4 family serving as one of the mRNA translation factors that modulate the process of mRNA translation based on mRNA characteristics. To address this causal role of EIF4 family proteins and breast cancer, Mendelian randomization was employed.
Methods: The study incorporated four sets of genetics instrumental variables, namely EIF4E, EIF4B, EIF4A, and EIF4EBP2. The outcome variables selected for analysis were the IN study and the BCAC consortium, which included estrogen receptor positive (ER+) and estrogen receptor negative (ER-) samples. To assess the potential violations of the MR assumption, the primary MR analysis employed random-effects inverse variance weighted (IVW), and several sensitivity analyses were conducted.
Results: The findings of the two-sample MR analysis indicate that EIF4E has an adverse effect on breast cancer risk( p = 0.028). However, the evidence for the relationship between EIF4E and ER status of breast cancer suggests a weak association with ER+ breast cancer(p =0.054), but not with ER- breast cancer(p >0.05). The study findings indicate that EIF4A is not causally linked to the risk of ER+ breast cancer, but is significantly associated with an elevated risk of ER- breast cancer (p = 0.028). However, the evidence is inadequate to support the effects of EIF4B and EIF4EBP2 on breast cancer (p >0.05).
Conclusions: Our results suggest that EIF4 may be a potential factor in the occurrence and development of breast cancer, which may lead to a better understanding of its causes and prevention.