bluuebunny/crossref_metadata_2025_split huggingface dataset:
Present Status and Perspectives of Graphene and Graphene‐related Materials in Cultural Heritage
Authors: Galvagno Erica , Tartaglia Edoardo , Stratigaki Maria , Tossi Camilla , Marasco Luigi , Menegazzo Federica , Zanardi Chiara , Omenetto Fiorenzo , Coletti Camilla , Traviglia Arianna , Moglianetti Mauro 
Published: January 2024

AbstractCultural heritage faces recurring degradation processes and natural aging phenomena, demanding the envisioning of innovative preservation solutions inspired by cutting‐edge scientific research. Over extended time frames, current preservation strategies often prove inadequate in preserving the different constituent materials of cultural assets, which are thus threatened by their inherent fragility and by the complex interactions with the surrounding environment. The distinctive properties of graphene and graphene‐related materials (GRMs) now offer unexplored opportunities in the field of cultural heritage, addressing various forms of deterioration phenomena. This work critically analyzes early‐stage literature on the use of graphene and GRMs. Strengths, weaknesses, and limitations in anti‐corrosion, anti‐fading, and consolidation properties of graphene and GRMs are thoroughly investigated, along with their possible applications in smart sensors to monitor the state of health of endangered artifacts. The aim is to elucidate how specific characteristics of graphene and GRMs can be applied to the conservation, diagnostics, and monitoring of artistic and archaeological assets. Future perspectives in the design of stable, long‐lasting, and compatible graphene‐based solutions for cultural heritage protection are highlighted, providing a detailed discussion on potentials and pitfalls.
Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration
Authors: Chen Li , Yang Jianye , Cai Zhengwei , Huang Yanran , Xiao Pengcheng , Wang Juan , Wang Fan , Huang Wei , Cui Wenguo , Hu Ning 
Published: January 2024

AbstractThe incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries is lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized to play an important role in bone and cartilage homeostasis and regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes and holds promise as an external intervention to enhance the synthesis of the extracellular matrix, thereby accelerating the process of bone and cartilage regeneration. Hence, electroactive biomaterials have been considered a biomimetic approach to ensure functional recovery by integrating various physiological signals, including electrical, biochemical, and mechanical signals. This review will discuss the role of endogenous bioelectricity in bone and cartilage tissue, as well as the effects of ES on cellular behaviors. Then, recent advances in electroactive materials and their applications in bone and cartilage tissue regeneration are systematically overviewed, with a focus on their advantages and disadvantages as tissue repair materials and performances in the modulation of cell fate. Finally, the significance of mimicking the electrophysiological microenvironment of target tissue is emphasized and future development challenges of electroactive biomaterials for bone and cartilage repair strategies are proposed.
Mitochondrial Localized In Situ Self‐Assembly Reprogramming Tumor Immune and Metabolic Microenvironment for Enhanced Cancer Therapy
Authors: Wang Zhilong , Wang Qian , Cao Hongmei , Wang Zhongyan , Wang Dianyu , Liu Jinjian , Gao Tongxin , Ren Chunhua , Liu Jianfeng 
Published: January 2024

AbstractThe inherent immune and metabolic tumor microenvironment (TME) of most solid tumors adversely affect the antitumor efficacy of various treatments, which is an urgent issue to be solved in clinical cancer therapy. In this study, a mitochondrial localized in situ self‐assembly system is constructed to remodel the TME by improving immunogenicity and disrupting the metabolic plasticity of cancer cells. The peptide‐based drug delivery system can be pre‐assembled into nanomicelles in vitro and form functional nanofibers on mitochondria through a cascade‐responsive process involving reductive release, targeted enrichment, and in situ self‐assembly. The organelle‐specific in situ self‐assemblyeffectively switches the role of mitophagy from pro‐survival to pro‐death, which finally induces intense endoplasmic reticulum stress and atypical type II immunogenic cell death. Disintegration of the mitochondrial ultrastructure also impedes the metabolic plasticity of tumor cells, which greatly promotes the immunosuppresive TME remodeling into an immunostimulatory TME. Ultimately, the mitochondrial localized in situ self‐assembly system effectively suppresses tumor metastases, and converts cold tumors into hot tumors with enhanced sensitivity to radiotherapy and immune checkpoint blockade therapy. This study offers a universal strategy for spatiotemporally controlling supramolecular self‐assembly on sub‐organelles to determine cancer cell fate and enhance cancer therapy.
An Integrated Charge Excitation Alternative Current Dielectric Elastomer Generator for Joint Motion Energy Harvesting
Authors: Xie Xinjun , Zheng Shaodi , Tan Jianbo , Cheng Jinzhan , Cai Jiancheng , Xu Zisheng , Shiju E  
Published: January 2024

AbstractJoint movement is a plentiful source of energy in living organisms; however, it is challenging to harvest due to its multidirectional nature, and effective technologies for harnessing this energy are lacking. In this study, a novel approach is presented to harvest joint motion energy by combining an alternating current dielectric elastomer generator (AC‐DEG) with an electret nanogenerator (ENG). The ACENG‐DEG, utilizing ion hydrogel electrodes and ENG, exhibits remarkable stretchability (860%) and efficiently converts mechanical energy into electrical energy through a stretch‐based mechanism. With only 37 cycles, the device reaches a saturation voltage of 1.18 kV and generates an output charge of 1.96 µC per cycle. Notably, the charge output response speed is approximately four times faster than that of traditional AC‐DEGs. The proposed strategy for harvesting human mechanical energy in this study represents a promising pathway for developing high‐performance energy harvesting devices and self‐powered systems.
Low‐Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells
Authors: Pu Congying , Li Yize , Fu Yixian , Yan Yiyang , Tao Siyao , Tang Shuai , Gai Xiameng , Ding Ziyi , Gan Zhenjie , Liu Yingluo , Cao Siyuwei , Wang Ting , Ding Jian , Xu Jun , Geng Meiyu , Huang Min 
Published: January 2024

AbstractIntervention of the gut microbiome is a promising adjuvant strategy in cancer immunotherapy. Chemotherapeutic agents are recognized for their substantial impacts on the gut microbiome, yet their therapeutic potential as microbiome modulators remains uncertain, due to the complexity of microbiome‐host‐drug interactions. Here, it is showed that low‐dose chemotherapy preferentially shapes the ileal microbiome to augment the extraintestinal immune response to anti‐programmed death‐1 (anti‐PD‐1) therapy without causing intestinal toxicity. Mechanistically, low‐dose chemotherapy causes DNA damage restricted to highly‐proliferative ileal epithelial cells, resulting in the accumulation of cytosolic dsDNA and the activation of the absent in melanoma 2 (AIM2) inflammasome. AIM2‐dependent IL‐18 secretion triggers the interplay between proximal Th1 cells and Paneth cells in ileal crypts, impairing the local antimicrobial host defense and resulting in ileal microbiome change. Intestinal epithelium‐specific knockout of AIM2 in mice significantly attenuates CPT‐11‐caused IL‐18 secretion, Paneth cell dysfunction, and ileal microbiome alteration. Moreover, AIM2 deficiency in mice or antibiotic microbial depletion attenuates chemotherapy‐augmented antitumor responses to anti‐PD1 therapy. Collectively, these findings provide mechanistic insights into how chemotherapy‐induced genomic stress is transduced to gut microbiome change and support the rationale of applying low‐dose chemotherapy as a promising adjuvant strategy in cancer immunotherapy with minimal toxicity.
TSP50 Attenuates DSS‐Induced Colitis by Regulating TGF‐β Signaling Mediated Maintenance of Intestinal Mucosal Barrier Integrity
Authors: Li Jiawei , Niu Chunxue , Ai Huihan , Li Xiaoli , Zhang Linlin , Lang Yan , Wang Shuyue , Gao Feng , Mei Xianglin , Yu Chunlei , Sun Luguo , Huang Yanxin , Zheng Lihua , Wang Guannan , Sun Ying , Yang Xiaoguang , Song Zhenbo , Bao Yongli 
Published: January 2024

AbstractThe integrity of the intestinal mucosal barrier is crucial for protecting the intestinal epithelium against invasion by commensal bacteria and pathogens, thereby combating colitis. The investigation revealed that the absence of TSP50 compromised the integrity of the intestinal mucosal barrier in murine subjects. This disruption facilitated direct contact between intestinal bacteria and the intestinal epithelium, thereby increasing susceptibility to colitis. Mechanistic analysis indicated that TSP50 deficiency in intestinal stem cells (ISCs) triggered aberrant activation of the TGF‐β signaling pathway and impeded the differentiation of goblet cells in mice, leading to impairment of mucosal permeability. By inhibiting the TGF‐β pathway, the functionality of the intestinal mucosal barrier is successfully restored and mitigated colitis in TSP50‐deficient mice. In conclusion, TSP50 played a crucial role in maintaining the intestinal mucosal barrier function and exhibited the preventive effect against the development of colitis by regulating the TGF‐β signaling pathway.
Enhanced Itinerant d0 Ferromagnetism and Tunable Topological Properties of a Ca2C/Ca2N Heterobilayer
Authors: Cao Guohua , Zhang Shunhong , Cui Ping , Zhang Zhenyu 
Published: January 2024

AbstractRecent studies have shown that a rich variety of exotic physical phenomena can emerge from the presence of electronic flat bands. Using first‐principles calculations, here a monolayered Ca2C possesses a relatively flat band near the Fermi level, and across the whole Brillouin zone is predicted. Next, the weak d0 ferromagnetism in Ca2C is substantially enhanced by a proximity‐coupled electride monolayer of Ca2N is shown. The enhanced magnetism can be attributed to the straightening of the flat band caused by the charge transfer to the electride, while the flattening is tied to the magic ratio of three between the σ and π channels of the effective C─C coupling strength. More surprisingly, even though each of the constituent systems is topologically trivial, the Ca2C/Ca2N heterobilayer is empowered with nontrivial band topology, characterized by a high Chern number tunable by the magnetization orientation or lateral strain. These findings provide a new platform for realizing intriguing magnetic topological metals in 2D materials.
Multi‐Interface Engineering of Self‐Supported Nickel/Yttrium Oxide Electrode Enables Kinetically Accelerated and Ultra‐Stable Alkaline Hydrogen Evolution at Industrial‐Level Current Density
Authors: Sun Hongming , Yao Bicen , Han Yixuan , Yang Le , Zhao Yidan , Wang Shuyu , Zhong Chongyang , Chen Jing , Li Cheng‐Peng , Du Miao 
Published: January 2024

AbstractThe development of highly active and robust non‐noble‐metal electrocatalysts for alkaline hydrogen evolution reaction (HER) at industrial‐level current density is the key for industrialization of alkaline water electrolysis. Herein, a superhydrophilic self‐supported Ni/Y2O3 heterostructural electrocatalyst is constructed by a high‐temperature selective reduction method, which demonstrates excellent catalytic performance for alkaline HER at high current density. Concretely, this catalyst can drive 10 mA cm−2 at a low overpotential of 61.1 ± 3.7 mV, with a low Tafel slope of 52.8 mV dec−1. Moreover, it also shows outstanding long‐term durability at high current density of 1000 mA cm−2 for 500 h in 1 m KOH, evidently exceeding the metallic Ni and Pt/C(20%) catalysts. The superior HER activity can be attributed to the multi‐interface engineering of the Ni/Y2O3 electrode. Construction of Ni/Y2O3 heterogeneous interface with dual active sites lowers the energy barrier of water dissociation and optimizes the hydrogen adsorption energy, thus synergistically accelerating the overall HER kinetics. Also, its superhydrophilic self‐supported electrode structure with the firm electrocatalyst‐substrate interface and weakened electrocatalyst‐bubble interfacial force ensures rapid charge transfer, prevents catalyst shedding, and expedites the H2 gas bubble release timely, further enhancing the catalytic activity and stability at high current density.
The effect of shift work on body mass index: A systematic review and meta‐analysis of observational studies
Authors: Łagowska Karolina , Kuleta‐Koberska Agnieszka , Michalak Michał , Bajerska Joanna 
Published: January 2024

AbstractContextShift work involves working outside the standard working hours of 9 am to 5 pm Monday to Friday and may include working evening, night, weekend, or rotating shift patterns. Since shift workers sleep less and their circadian rhythms are disrupted, they are reported to have higher body weight than day workers.ObjectiveThis meta‐analysis aims to determine whether shift workers (SW) are more prone to higher body mass index (BMI) than their day workers (DW) counterparts. It also addresses the question of whether the duration of shift work exposure, sex, or occupational type affect BMI value.MethodsFour databases that is PubMed, EBSCO Host, Scopus, and Web of Science were searched for reports published up to October 2023.ResultsSixty‐three studies involving a total of 693 449 participants met our inclusion criteria. Meta‐analyses showed a significant effect of shift work on BMI value (standard mean difference; SMD: 0.10 kg/m2 [95% confidence interval; 95% CI: 0.07; 0.13; p < .001]) as compared with non‐shift counterparts. Subgroup analysis revealed that shift work significantly increased BMI for studies where male working on this job schedule (SMD: 0.10 kg/m2 [95% CI: 0.04; 0.17; p = .0018]) for studies where shift workers worked ≥13 years (calculated as the median of shift work experience; SMD: 0.14 kg/m2 [95% CI: 0.10; 0.18; p < .001]) as well as for studies where industrial (SMD: 0.12 kg/m2 [95% CI: 0.05; 0.19; p = .0012]) and other type of occupations were dominated (0.12 kg/m2 [95% CI: 0.07; 0.16; p < .001]).ConclusionsWe found that in general working on a shift schedule increases BMI as compared with day workers, especially in case of male employed in this job schedule, for shift workers working for long periods of time (≥13 years), and for shift workers employed in industry and other type of occupations(e.g., airline workers, firefighters, police officers, blue collar, security personnel, bus drivers, garbage collectors, railway workers, postal, oil and gas workers).
Macrocyclic Dual‐Locked “Turn‐On” Drug for Selective and Traceless Release in Cancer Cells
Authors: Schauenburg Dominik , Gao Bingjie , Rochet Léa N. C. , Schüler Darijan , Coelho Jaime A. S. , Ng David Y. W. , Chudasama Vijay , Kuan Seah Ling , Weil Tanja 
Published: January 2024

AbstractDrug safety and efficacy due to premature release into the bloodstream and poor biodistribution remains a problem despite seminal advances in this area. To circumvent these limitations, we report drug cyclization based on dynamic covalent linkages to devise a dual lock for the small‐molecule anticancer drug, camptothecin (CPT). Drug activity is “locked” within the cyclic structure by the redox responsive disulfide and pH‐responsive boronic acid‐salicylhydroxamate and turns on only in the presence of acidic pH, reactive oxygen species and glutathione through traceless release. Notably, the dual‐responsive CPT is more active (100‐fold) than the non‐cleavable (permanently closed) analogue. We further include a bioorthogonal handle in the backbone for functionalization to generate cyclic‐locked, cell‐targeting peptide‐ and protein‐CPTs, for targeted delivery of the drug and traceless release in triple negative metastatic breast cancer cells to inhibit cell growth at low nanomolar concentrations.
Efficient and Stable Tin‐Lead Mixed Perovskite Solar Cells Using Post‐Treatment Additive with Synergistic Effects
Authors: Ding Xingdong , Yan Meng , Chen Cheng , Zhai Mengde , Wang Haoxin , Tian Yi , Wang Linqin , Sun Licheng , Cheng Ming 
Published: January 2024

AbstractInhibiting the oxidation of Sn2+ during the crystallization process of Sn−Pb mixed perovskite film is found to be as important as the oxidation resistance of precursor solution to achieve high efficiency, but less investigated. Considering the excellent reduction feature of hydroquinone and the hydrophobicity of tert‐butyl group, an antioxidant 2,5‐di‐tert‐butylhydroquinone (DBHQ) was introduced into Sn−Pb mixed perovskite films using an anti‐solvent approach to solve this problem. Interestingly, we find that DBHQ can act as function alterable additive during its utilization. On the one hand, DBHQ can restrict the oxidation of Sn2+ during the crystallization process, facilitating the fabrication of high‐quality perovskite film; on the other hand, the generated oxidation product 2,5‐di‐tert‐butyl‐1,4‐benzoquinone (DBBQ) can functionalize as defect passivator to inhibit the charge recombination. As a result, this synergetic effect renders the Sn−Pb mixed PSC a power conversion efficiency (PCE) up to 23.0 %, which is significantly higher than the reference device (19.6 %). Furthermore, the unencapsulated DBQH‐modified PSCs exhibited excellent long‐term stability and thermal stability, with the devices maintaining 84.2 % and 78.9 % of the initial PCEs after aging at 25 °C and 60 °C for 800 h and 120 h under N2 atmosphere, respectively. Therefore, the functional alterable strategy provides a novel cornerstone for high‐performance Sn−Pb mixed PSCs.
Site‐Specific Deaminative Trifluoromethylation of Aliphatic Primary Amines**
Authors: Xue Jiang‐Hao , Li Yin , Liu Yuan , Li Qingjiang , Wang Honggen 
Published: January 2024

AbstractThe introduction of trifluoromethyl groups into organic molecules is of paramount importance in modern synthetic chemistry and medicinal chemistry. While methods for constructing C(sp2)−CF3 bonds have been well established, the advancement of practical and comprehensive approaches for forming C(sp3)−CF3 bonds remains considerably restricted. In this work, we describe an efficient and site‐specific deaminative trifluoromethylation reaction of aliphatic primary amines to afford the corresponding alkyl trifluoromethyl compounds. The reaction proceeds at room temperature with readily accessible N‐anomeric amide (Levin's reagent) and bench‐stable bpyCu(CF3)3 (Grushin's reagent, bpy=2,2′‐bipyridine) under blue light. The protocol features mild reaction conditions, good functional group tolerance, and moderate to good yields. Remarkably, the method can be applied to the direct, late‐stage trifluoromethylation of natural products and bioactive molecules. Experimental mechanistic studies were conducted, and a radical mechanism is proposed, wherein the dual roles of Grushin's reagent have been elucidated.
Localized Medium Concentration Electrolyte with Fast Kinetics for Lithium Metal Batteries
Authors: Li Pengcheng , Zhang Zhiqing , Zhao Ziwei , Zhang Xuzi , Zhang Hao , Li Ge 
Published: January 2024

AbstractLocalized high‐concentration electrolyte is widely acknowledged as a cutting‐edge electrolyte for the lithium metal anode. However, the high fluorine content, either from high‐concentration salts or from highly fluorinated diluents, results in significantly higher production costs and an increased environmental burden. Here, we have developed a novel electrolyte termed “Localized Medium‐Concentration Electrolyte” (LMCE) to effectively address these issues. This LMCE is designed and produced by diluting a medium concentration (0.5 M–1.5 M) electrolyte which is incompatible with lithium metal anode before diluting. It has ultralow concentration (0.1 M) and demonstrates remarkable compatibility with lithium metal anode. Surprisingly, our LMCE, despite having an ultralow concentration (0.1 M), exhibits excellent kinetics in Li/Cu, Li/Li, LiFePO4/Li, and NCM811/Li batteries. Additionally, LMCE effectively inhibits the corrosion of the Al current collector caused by LiTFSI salt under high voltage (>4 V) conditions. This groundbreaking LMCE design transforms the seemingly “incompatible” into the “compatible”, opening up new avenues for exploring various electrolyte formulations, including all liquid electrolyte‐based batteries.
Construction of C−S and C−Se Bonds from Unstrained Ketone Precursors under Photoredox Catalysis
Authors: Wu Hao , Chen Shuguang , Liu Chunni , Zhao Quansheng , Wang Zhen , Jin Qiren , Sun Shijie , Guo Jing , He Xinwei , Walsh Patrick J , Shang Yongjia 
Published: January 2024

AbstractA mild photoredox catalyzed construction of sulfides, disulfides, selenides, sulfoxides and sulfones from unstrained ketone precursors is introduced. Combination of this deacylative process with SN2 or coupling reactions provides novel and convenient modular strategies toward unsymmetrical or symmetric disulfides. Reactivity studies favor a bromine radical that initiates a HAT (Hydrogen Atom Transfer) from the aminal intermediate resulting in expulsion of a C‐centered radical that is intercepted to make C−S and C−Se bonds. Gram scale reactions, broad substrate scope and tolerance towards various functional groups render this method appealing for future applications in the synthesis of organosulfur and selenium complexes.
Thrombolysis and mechanical cardiopulmonary resuscitation for pulmonary embolism complicated by hepatic and splenic lacerations resulting in major haemorrhage
Authors: Flower L. , Extremera‐Navas P. , Mackenney J. 
Published: January 2024

SummaryThrombolysis with prolonged cardiopulmonary resuscitation may be required for the successful resuscitation of patients presenting with massive pulmonary embolism leading to cardiac arrest. A rare, recognised complication of cardiopulmonary resuscitation is traumatic hepatic and splenic laceration. The incidence of complications is believed to be increased in those who receive automated mechanical cardiopulmonary resuscitation, compared to those who receive standard chest compressions. We present a case of a patient with massive pulmonary embolism leading to cardiac arrest which was successfully treated with thrombolysis and mechanical automated cardiopulmonary resuscitation. The patient suffered hepatic and splenic lacerations resulting in major haemorrhage. This required emergency resuscitation with blood products and splenic embolisation. This case highlights the importance of continual re‐assessment of patients, the early recognition of complications and an awareness of the potential complications of treatments we deliver.
Construction of an Oxidative Cleavage‐Activated DNAzyme Biosensor for Rapid Detection and Cellular Imaging of the Myeloperoxidase Activity
Authors: Liu Ming‐Hao , Zhao Ning‐Ning , Yu Wan‐Tong , Zhang Jin‐Zhi , Wang Zi‐Yue , Zhang Chun‐Yang 
Published: January 2024

AbstractInvited for this month's cover is the collaborating group of Prof. Chun‐Yang Zhang at Southeast University, China and colleagues at Shandong Normal University. The cover picture shows the formation of oxidative cleavage‐activated DNAzyme that enables imaging of myeloperoxidase in living cells. More information can be found in the Research Article by Zi‐Yue Wang, Chun‐Yang Zhang, and co‐workers.