bluuebunny/crossref_metadata_2025_split huggingface dataset:
Care needs assessment of older adults with dementia in a semi‐rural district in Vietnam: A community‐based cross‐sectional study
Authors: Nguyen Anh Ngoc , Nguyen Binh Thanh , Nguyen Binh Thanh , Nguyen Binh Thi Thanh , Nguyen Nguyet Thi Anh , Dang Nhung Thi Kim , Nguyen Anh Thi Phuong , Nguyen Anh Trung , Pham Thang , Mantyh William Guntars , Tran Duyen , Le Oanh Thi Phương , Park Van My Ta 
Published: December 2023

AbstractBackgroundThe increasing needs of people living with dementia (PLWD) in Vietnam present an enormous public health challenge. Vietnam is an understudied country, and little is known regarding the overall unmet needs of caregivers or the demographic risk factors associated with unmet caregiving needs. This study aimed to determine the burden of unmet care needs of community‐dwelling PLWD and identify sociodemographic risks associated with unmet care needs.MethodsA cross‐sectional study in a rural area facing urbanisation in Hanoi, Vietnam recruited PWLD‐caregiver dyads with multistage sampling. We utilised the Camberwell Assessment of Need for the Elderly (CANE) instrument to evaluate care needs across four domains. Caregivers rated PLWD needs, with higher scores indicating greater unmet needs. The Mann–Whitney test was employed for comparing two groups, while the Kruskal–Wallis test was used for comparisons involving more than two groups in the analysis, and a P‐value of less than 0.05 was considered statistically significant.ResultsAmong 90 PLWD participating in the study, the overall mean care needs score was 11.6 ± 4.3, with only 16.2% of PLWD having their care needs met. Environmental and physical needs were more frequently met than psychological or social needs. Only 48.0% and 43.9% of environmental and physical needs were met respectively, and a meagre 20.9% and 23.6% for psychological and social needs. Unmet care needs were more frequent for PWLD who were female, single or divorced, had lower monthly household income, or who were in more advanced stages of dementia, as indicated by Clinical Dementia Rating scores ≥1.ConclusionsUnmet needs for PWLD are common. Increased caregiver education, resources, and services in Vietnam are urgently required to improve the quality of life for this population.
Registered replication report of the construct validity of the error‐related negativity (ERN): A multi‐site study of task‐specific ERN correlations with internalizing and externalizing symptoms
Authors: Clayson Peter E. , Mcdonald Julia B. , Park Bohyun , Holbrook Amanda , Baldwin Scott A. , Riesel Anja , Larson Michael J. 
Published: December 2023

AbstractIntact cognitive control is critical for goal‐directed behavior and is widely studied using the error‐related negativity (ERN). A common assumption in such studies is that ERNs recorded during different experimental paradigms reflect the same construct or functionally equivalent processes and that ERN is functionally distinct from other error‐monitoring event‐related brain potentials (ERPs; error positivity [Pe]), other neurophysiological indices of cognitive control (N2), and even other theoretically unrelated indices (visual N1). The present registered report represents a replication‐plus‐extension study of the psychometric validity of cognitive control ERPs and evaluated the convergent and divergent validity of ERN, Pe, N2, and visual N1 recorded during flanker, Stroop, and Go/no‐go tasks. Data from 182 participants were collected from two study sites, and ERP psychometric reliability and validity were evaluated. Findings supported replication of convergent and divergent validity of ERN, Pe, and ΔPe (error minus correct)—these ERPs correlated more with themselves across tasks than with other ERPs measured during the same task. Convergent validity of ΔERN across tasks was not replicated, despite high internal consistency. ERN strongly correlated with N2 at levels similar or higher than those in support of convergent validity for other ERPs, and the present study failed to provide evidence of divergent validity for ERN and Pe from N2 or N1. ERN and ΔERN were unrelated to internalizing or externalizing symptoms. Findings underscore the importance of considering the psychometric validity of ERPs, as it provides a foundation for interpreting and comparing ERPs across tasks and studies.
Effective peripheral blood stem cell collection in a 4.6‐kg child
Authors: Jones Jennifer M. , Kiss Joseph E. , Chibisov Irina , Horvei Paulina , Stanczak Heather , Burda Carol , Clark Wei , Sevcik Joan , Kilonsky Carolyn , Kaplan Alesia 
Published: December 2023

AbstractBackgroundDue to unique technical challenges, effective peripheral blood stem cell collections (PBSCs) have not been consistently reported in patients weighing less than 5 kg. We describe three PBSCs performed in a 4.6‐kg child undergoing myeloablative chemotherapy for high‐grade glioma.Study Design and MethodsA multidisciplinary group representing the clinical and apheresis teams adapted a PBSC protocol to accommodate the patient's size and collection targets. Special considerations included timing of the collection relative to chemotherapy, vascular access, strategies for monitoring adverse events during collection, and contingencies.Results and DiscussionThe patient underwent three PBSC procedures over 2 days due to suboptimal collection after the first two procedures. For procedure 1, a conservative inlet: anticoagulant (AC) ratio and AC infusion rate of 15 and 0.6 mL/min/L total blood volume (TBV) resulted in premature discontinuation due to clotting. A ratio of 8 and AC infusion rate of 1.5–1.7 mL/min/L TBV with subsequent titration to higher levels were adopted for the second and third procedures. These changes resulted in greater acid‐citrate‐dextrose exposure, that was managed by continuous calcium chloride infusion. There was no hypocalcemia, hypotension, or distress during any procedure. A total of 15 × 106 CD34+ cells/kg were collected. This retrospective review illustrates that PBSC can be safely undertaken in children weighing less than 5 kg.
Gut microbiota in regulation of childhood bone growth
Authors: Lui Julian C. 
Published: December 2023

AbstractChildhood stunting and wasting, or decreased linear and ponderal growth associated with undernutrition, continue to be a major global public health challenge. Although many of the current therapeutic and dietary interventions have significantly reduced childhood mortality caused by undernutrition, there remain great inefficacies in improving childhood stunting. Longitudinal bone growth in children is governed by different genetic, nutritional and other environmental factors acting systemically on the endocrine system and locally at the growth plate. Recent studies have shown that this intricate interplay between nutritional and hormonal regulation of the growth plate could involve the gut microbiota, highlighting the importance of a holistic approach in tackling childhood undernutrition. In this review, I focus on the mechanistic insights provided by these recent advances in gut microbiota research and discuss ongoing development of microbiota‐based therapeutics in humans, which could be the missing link in solving undernutrition and childhood stunting.
Chronic intermittent hypoxia remodels catecholaminergic nerve innervation in mouse atria
Authors: Bizanti Ariege , Zhang Yuanyuan , Toledo Zulema , Bendowski Kohlton T. , Harden Scott W. , Mistareehi Anas , Chen Jin , Gozal David , Heal Maci , Christie Richard , Hunter Peter J. , Paton Julian F.R. , Cheng Zixi Jack 
Published: December 2023

AbstractChronic intermittent hypoxia (CIH, a model for sleep apnoea) is a major risk factor for several cardiovascular diseases. Autonomic imbalance (sympathetic overactivity and parasympathetic withdrawal) has emerged as a causal contributor of CIH‐induced cardiovascular disease. Previously, we showed that CIH remodels the parasympathetic pathway. However, whether CIH induces remodelling of the cardiac sympathetic innervation remains unknown. Mice (male, C57BL/6J, 2–3 months) were exposed to either room air (RA, 21% O2) or CIH (alternating 21% and 5.7% O2, every 6 min, 10 h day–1) for 8–10 weeks. Flat‐mounts of their left and right atria were immunohistochemically labelled for tyrosine hydroxylase (TH, a sympathetic marker). Using a confocal microscope (or fluorescence microscope) and Neurlocudia 360 digitization and tracing system, we scanned both the left and right atria and quantitatively analysed the sympathetic axon density in both groups. The segmentation data was mapped onto a 3D mouse heart scaffold. Our findings indicated that CIH significantly remodelled the TH immunoreactive (‐IR) innervation of the atria by increasing its density at the sinoatrial node, the auricles and the major veins attached to the atria (P < 0.05, n = 7). Additionally, CIH increased the branching points of TH‐IR axons and decreased the distance between varicosities. Abnormal patterns of TH‐IR axons around intrinsic cardiac ganglia were also found following CIH. We postulate that the increased sympathetic innervation may further amplify the effects of enhanced CIH‐induced central sympathetic drive to the heart. Our work provides an anatomical foundation for the understanding of CIH‐induced autonomic imbalance.
imageKey points
Chronic intermittent hypoxia (CIH, a model for sleep apnoea) causes sympathetic overactivity, cardiovascular remodelling and hypertension.
We determined the effect of CIH on sympathetic innervation of the mouse atria.
In vivo CIH for 8–10 weeks resulted in an aberrant axonal pattern around the principal neurons within intrinsic cardiac ganglia and an increase in the density, branching point, tortuosity of catecholaminergic axons and atrial wall thickness.
Utilizing mapping tool available from NIH (SPARC) Program, the topographical distribution of the catecholaminergic innervation of the atria were integrated into a novel 3D heart scaffold for precise anatomical distribution and holistic quantitative comparison between normal and CIH mice.
This work provides a unique neuroanatomical understanding of the pathophysiology of CIH‐induced autonomic remodelling.
The Inclusion of Preplanned and Random and Unanticipated/Unexpected Events During Strength Training Improves the Ability to Repeat High-Intensity Efforts Under Uncertainty
Authors: Gonzalo-Skok Oliver , Tous-Fajardo Julio , Maroto-Izquierdo Sergio , Raya-González Javier , Sánchez-Sánchez Javier 
Published: December 2023

Purpose: To compare the effects of unilateral flywheel training (FT), using a rotational conical pulley, including multidirectional movements with either preplanned or random unanticipated/unexpected executions on functional performance in football players. Methods: A total of 32 young male football players were randomly assigned to an FT program including preplanned unilateral multidirectional movements (PTG, n = 11), an FT executing the same unilateral movements through random (ie, right or left leg) unanticipated (ie, verbal or visual cue) or unexpected (ie, moment where the cue was provided) situations (UTG, n = 11), or a control group (n = 10) that followed their football training routine. FT consisted of 1 set × 5–12 repetitions of 4 exercises performed once a week for 10 weeks. Intermittent endurance performance, repeated unilateral and bilateral jumping ability, change-of-direction (COD) ability, linear sprint velocity, preplanned repeated-sprint ability (RSA), and uncertainty RSA (RSA-RANDOM) were assessed preintervention and postintervention. Results: Significant improvements were found in RSA-RANDOM performance (P < .05, effect size [ES] range: UTG [1.83–2.16], PTG [0.69–0.73]) and COD (P < .05, ES: UTG = 1.34, PTG = 0.98]) in both training groups. Furthermore, significant improvements were also found in intermittent endurance performance (P = .016, ES = 0.37) and sprinting (P = .006, ES = 0.45) in UTG. No changes in any variable were found in the control group. No significant between-groups differences (P > .05) were reported between UTG and PTG, while differences were observed to the control group in unilateral jumping ability, COD, and RSA-RANDOM for UTG, and in RSA-RANDOM for PTG. Conclusions: A 10-week unilateral FT improved RSA-RANDOM and COD ability in youth football players, so both preplanned and unexpected situations should be included on strength training.
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Authors: Clocchiatti‐Tuozzo Santiago , Rivier Cyprien A. , Renedo Daniela , Torres Lopez Victor M. , Geer Jacqueline H. , Miner Brienne , Yaggi Henry K. , de Havenon Adam , Payabvash Seyedmehdi , Sheth Kevin N. , Gill Thomas M. , Falcone Guido J. 
Published: December 2023

Background
The American Heart Association's Life's Simple 7, a public health construct capturing key determinants of cardiovascular health, became the Life's Essential 8 after the addition of sleep duration. The authors tested the hypothesis that suboptimal sleep duration is associated with poorer neuroimaging brain health profiles in asymptomatic middle‐aged adults.

Methods and Results

The authors conducted a prospective magnetic resonance neuroimaging study in middle‐aged individuals without stroke or dementia enrolled in the UK Biobank. Self‐reported sleep duration was categorized as short (<7 hours), optimal (7–<9 hours), or long (≥9 hours). Evaluated neuroimaging markers included the presence of white matter hyperintensities (WMHs), volume of WMH, and fractional anisotropy, with the latter evaluated as the average of 48 white matter tracts. Multivariable logistic and linear regression models were used to test for an association between sleep duration and these neuroimaging markers. The authors evaluated 39 771 middle‐aged individuals. Of these, 28 912 (72.7%) had optimal, 8468 (21.3%) had short, and 2391 (6%) had long sleep duration. Compared with optimal sleep, short sleep was associated with higher risk of WMH presence (odds ratio, 1.11 [95% CI, 1.05–1.18];
P
<0.001), larger WMH volume (beta=0.06 [95% CI, 0.04–0.08];
P
<0.001), and worse fractional anisotropy profiles (beta=−0.04 [95% CI, −0.06 to −0.02];
P
=0.001). Compared with optimal sleep, long sleep duration was associated with larger WMH volume (beta=0.04 [95% CI, 0.01–0.08];
P
=0.02) and worse fractional anisotropy profiles (beta=−0.06 [95% CI, −0.1 to −0.02];
P
=0.002), but not with WMH presence (
P
=0.6).

Conclusions
Among middle‐aged adults without stroke or dementia, suboptimal sleep duration is associated with poorer neuroimaging brain health profiles. Because these neuroimaging markers precede stroke and dementia by several years, these findings are consistent with other findings evaluating early interventions to improve this modifiable risk factor.
Expanding Confiscation and its Dimensions in EU Criminal Law
Authors: Hryniewicz-Lach Elżbieta 
Published: December 2023

Abstract
This article presents the types of extensions observed in the field of asset confiscation in EU criminal law: the extension of the scope of eligible assets at the EU level, the extensive implementation of relevant EU law into national legal orders and the expansion of the territorial effectiveness of confiscation orders. The attention is given also to the EU’s legislative competence in the field of confiscation and to expanding the basis for the application of asset confiscation at the EU level. The article is concluded with some observations on important aspects of asset confiscation, which should be taken into account by broadening the scope of confiscation at the EU level. In the article presented are partial results of research project: ‘Extended confiscation and its justification in light of fundamental rights and general principles of EU law’, financed by the National Science Centre, Poland, in years 2021–2024 (project number: 2020/39/d/hs5/01114).
A comparison of damping-based methods to identify damage to carbon-fiber-reinforced polymers laminates subjected to low-velocity impact
Authors: Rouhi Moghanlou Mohammad , Mahmoudi Ali , Khonsari MM , Li G 
Published: December 2023

A method for detecting low-velocity impact damage in carbon fiber reinforced polymer (CFRP) is presented. It involves the use of the Impulse Excitation Technique (IET) and hysteresis loops to calculate the damping parameter of T700/NCT304-1 carbon/epoxy samples subjected to various low-velocity impact energies. The value of the coefficient of restitution (COR) is determined for each impact, ranging between 0.62 for the lowest impact energy to 0.48 for the highest one. The results reveal that a three-step increase in the damping parameter exists in all cases as the impact energy on the specimen increases. An abrupt jump in the damping parameter value is observed for impact energies exceeding ∼0.9 of the material's maximum capacity. Overall, at the highest impact energy equal to 3.65 J, the damping parameter increased by 43.3% compared to the pristine specimen. Additionally, two cases of cyclic tension-tension loading were applied to the specimens, with maximum stresses set at 150 MPa and 200 MPa. The measured values of plastic and elastic strain energy were used to determine the damping ratios. For both cases, the damping of the specimen subjected to the highest impact energy was ∼1.2 times greater than that of an intact specimen, with an increase pattern similar to the findings of the IET method. Optical microscope images of the specimens are provided to illustrate various damage modes observed in the composite materials.
Overestimation of Survival Rates of Cardiopulmonary Resuscitation Is Associated with Higher Preferences to Be Resuscitated: Evidence from a National Survey of Older Adults in Switzerland
Authors: Meier Clément , Vilpert Sarah , Wieczorek Maud , Borasio Gian Domenico , Jox Ralf J. , Maurer Jürgen 
Published: December 2023

Background Many widely used advance directives templates include direct questions on individuals’ preferences for cardiopulmonary resuscitation (CPR) in case of decision-making incapacity during medical emergencies. However, as knowledge of the survival rates of CPR is often limited, individuals’ advance decisions on CPR may be poorly aligned with their preferences if false beliefs about the survival rates of CPR shape stated preferences for CPR. Methods We analyzed nationally representative data from 1,469 adults aged 58+ y who responded to wave 8 (2019/2020) of the Swiss version of the Survey on Health, Ageing, and Retirement in Europe (SHARE) to assess the partial association between knowledge of CPR survival rates and stated preferences for CPR using multivariable probit regression models that adjust for social, health, and regional characteristics. Knowledge of CPR survival rates was assessed by asking how likely it is in general in Switzerland for a 70-y-old to survive until hospital discharge from a CPR performed outside of a hospital. Preferences for CPR were measured by asking respondents if they would wish to be resuscitated in case of cardiac arrest. Results Only 9.3% of respondents correctly assessed the chances for a 70-y-old to survive until hospital discharge from a CPR performed outside of a hospital, while 65.2% indicated a preference to be resuscitated in case of a cardiac arrest. Respondents who correctly assessed CPR survival were significantly more likely to wish not to be resuscitated (average marginal effect: 0.18, P < 0.001). Conclusions Reducing misconceptions concerning the survival rates of CPR could change older adults’ preferences for CPR and make them more likely to forgo such treatments. Highlights Many older adults in Switzerland overestimate the survival rates of cardiopulmonary resuscitation (CPR). The study reveals that individuals with accurate knowledge of CPR survival rates are more likely to refuse resuscitation in case of cardiac arrest. Overestimation of CPR survival rates may lead to a mismatch between individuals’ preferences for CPR and their actual end-of-life care decisions. Improving the general population’s knowledge of CPR survival rates is crucial to ensure informed decision making and effective advance care planning.
Is endoscopic radiofrequency ablation plus stent placement superior to stent placement alone for the treatment of malignant biliary obstruction? A systematic review and meta-analysis
Authors: Liu Chenming , Dong Jiaming , Liu Yuxing , Zhang Siyuan , Chen Ruanchang , Tang Haijun 
Published: December 2023

Objective Malignant biliary obstruction (MBO) is a rare disease with a poor prognosis. Recent studies have shown that endoscopic radiofrequency ablation (ERFA) may improve survival. We conducted a systematic review and meta-analysis of the efficacy of ERFA in combination with biliary stent placement for the treatment of MBO. Methods The study was registered in INPLASY (number 202340096). The PubMed, Cochrane Library, Web of Science, and Embase databases were searched from inception to April 2023. We selected studies comparing the efficacy of ERFA plus stent placement with stent placement alone. The primary outcomes were pooled hazard ratios (HRs) for overall survival and stent patency; the secondary outcomes were the odds ratios (ORs) for adverse events. Results Eleven studies (four randomized controlled trials and seven observational studies) were included in the meta-analysis. Pooled analysis showed a difference in survival time between the two groups (HR 0.65, 95% confidence interval [CI] 0.58–0.73, I2 = 40%). However, there were no differences in the duration of stent patency or the incidence of adverse events (HR 1.04, 95% CI 0.84–1.29, I2 = 46%; OR 1.41, 95% CI 1.02–1.96, I2 = 29%). Conclusions ERFA has a significant survival benefit for MBO, but does not increase the risk of adverse events.
Comparing Methods of Seizure Response Monitoring During Electroconvulsive Therapy: Comparer les méthodes de surveillance des interventions en cas de crise durant la thérapie par électrochocs
Authors: Hierlihy Timothy , Mugford Gerald , Bonnell Weldon , Mekawy Mohamed A. 
Published: December 2023

Objective Electroconvulsive therapy (ECT) is used to treat several mental illnesses. Seizure duration is used to determine if the administered stimulus was adequate. Duration is estimated by electroencephalogram (EEG) interpretation and/or observed motor response (OMR). Neither method is considered the gold standard. This study investigated the relationship between the 2 methods. The hypothesis was that both EEG and OMR would be significantly positively correlated. Previous researchers have suggested that the 2 methods resulted in different estimates. Methods A case series was conducted using recorded estimates obtained prospectively from 102 ECTs on adult psychiatric inpatients. Results A strong positive association was not observed in this study, correlation coefficient 0.510 ( p < 0.001). Conclusions This study suggests that the 2 methods differ, and further research is needed to determine the best indicator of adequate treatment.