bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation in seizure risk increases from antiseizure medication withdrawal among patients with well‐controlled epilepsy: A pooled analysis
Authors: Terman Samuel W. , Slinger Geertruida , Koek Adriana , Skvarce Jeremy , Springer Mellanie V. , Ziobro Julie M. , Burke James F. , Otte Willem M. , Thijs Roland D. , Lossius Morten I. , Marson Anthony G. , Bonnett Laura J. , Braun Kees P. J. 
Published: December 2023

AbstractObjectiveGuidelines suggest considering antiseizure medication (ASM) discontinuation in seizure‐free patients with epilepsy. Past work has poorly explored how discontinuation effects vary between patients. We evaluated (1) what factors modify the influence of discontinuation on seizure risk; and (2) the range of seizure risk increase due to discontinuation across low‐ versus high‐risk patients.MethodsWe pooled three datasets including seizure‐free patients who did and did not discontinue ASMs. We conducted time‐to‐first‐seizure analyses. First, we evaluated what individual patient factors modified the relative effect of ASM discontinuation on seizure risk via interaction terms. Then, we assessed the distribution of 2‐year risk increase as predicted by our adjusted logistic regressions.ResultsWe included 1626 patients, of whom 678 (42%) planned to discontinue all ASMs. The mean predicted 2‐year seizure risk was 43% [95% confidence interval (CI) 39%–46%] for discontinuation versus 21% (95% CI 19%–24%) for continuation. The mean 2‐year absolute seizure risk increase was 21% (95% CI 18%–26%). No individual interaction term was significant after correcting for multiple comparisons. The median [interquartile range (IQR)] risk increase across patients was 19% (IQR 14%–24%; range 7%–37%). Results were unchanged when restricting analyses to only the two RCTs.SignificanceNo single patient factor significantly modified the influence of discontinuation on seizure risk, although we captured how absolute risk increases change for patients that are at low versus high risk. Patients should likely continue ASMs if even a 7% 2‐year increase in the chance of any more seizures would be too much and should likely discontinue ASMs if even a 37% risk increase would be too little. In between these extremes, individualized risk calculation and a careful understanding of patient preferences are critical. Future work will further develop a two‐armed individualized seizure risk calculator and contextualize seizure risk thresholds below which to consider discontinuation.Plain Language SummaryUnderstanding how much antiseizure medications (ASMs) decrease seizure risk is an important part of determining which patients with epilepsy should be treated, especially for patients who have not had a seizure in a while. We found that there was a wide range in the amount that ASM discontinuation increases seizure risk—between 7% and 37%. We found that no single patient factor modified that amount. Understanding what a patient's seizure risk might be if they discontinued versus continued ASM treatment is critical to making informed decisions about whether the benefit of treatment outweighs the downsides.
A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery
Authors: Zhu Ya‐Xuan , Jia Hao‐Ran , Jiang Yao‐Wen , Guo Yuxin , Duan Qiu‐Yi , Xu Ke‐Fei , Shan Bai‐Hui , Liu Xiaoyang , Chen Xiaokai , Wu Fu‐Gen 
Published: December 2023

AbstractThe tumour‐targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome of anticancer treatment. Major challenges lie in the complexity of diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcellular targets. Herein, an “all‐in‐one” red blood cell (RBC)‐derived microrobot that can hierarchically adapt to five critical stages during systemic drug delivery, that is, circulation, accumulation, release, extravasation, and penetration, is developed. The microrobots behave like natural RBCs in blood circulation, due to their almost identical surface properties, but can be magnetically manipulated to accumulate at regions of interest such as tumours. Next, the microrobots are “immolated” under laser irradiation to release their therapeutic cargoes and, by generating heat, to enhance drug extravasation through vascular barriers. As a coloaded agent, pirfenidone (PFD) can inhibit the formation of extracellular matrix and increase the penetration depth of chemodrugs in the solid tumour. It is demonstrated that this system effectively suppresses both primary and metastatic tumours in mouse models without evident side effects, and may represent a new class of intelligent biomimicking robots for biomedical applications.
Construction and application of standardized training effect evaluation system for new nurses in operating room
Authors: Liu Xiaoli , Wei Yanshu , Pei Jin , Wu Xiaozhou 
Published: December 2023

AbstractBackgroundThis study aims to develop and validate a Structured Training Effectiveness Evaluation (STEE) tool based on the Kirkpatrick model for newly graduated registered nurses in the operating room in China.MethodsThe first phase will involve focus group and individual interviews with nursing educators and newly graduated registered nurses selected using purposive sampling. The data will be analyzed thematically to identify key components necessary to develop the STEE tool. The second phase will develop and validate the STEE tool through a panel of experts using the Delphi method. The item weights will be determined with the analytic hierarchy process technique. The third phase will involve implementation and evaluation of the STEE tool with an exploratory, nonexperimental, and comparative analysis. Descriptive and inferential statistical analyses will be performed with SPSS version 23.ResultsThe STEE tool for newly graduated registered nurses in the operating room will be useful for evaluating training effectiveness during standardized training. The results obtained with this tool will clarify the effectiveness of training, thereby helping transform nursing students into competent nurses.ConclusionIn this way, this study will provide practical guidance for improving standardized training programs and help newly graduated nurses manage their transition to the clinical work environment and remain in their posts.
Sedentary behaviour in Australian university students: The contribution of study‐related sedentary behaviour to total sedentary behaviour
Authors: Sutherland Casey A. , Cole Rachel L. , Kynn Mary , Gray Marion A. 
Published: December 2023

AbstractIssue AddressedSeated activities are attributed to increased sedentary behaviour (SB) and adverse health effects, but little is currently known about university students' SB, particularly study‐related SB. This study describes the sociodemographic variations of domain‐specific SB in regional Australian university students and the contribution of study‐related SB to total SB.MethodsSelf‐reported daily SBs from a cross‐sectional survey of 451 students were used. Domain‐specific and total SB were described within sub‐groups, and differences examined using independent t‐tests. Multinomial regression was used to examine the association of tertiles of duration in study‐related SB with total and other domain‐specific SBs.ResultsStudy participants were a median age of 21 (19–25 years), mostly female (76%) and represented different years of study. On average, students spent 882 ± 292 min/day in total SB, with most SB occurring in the study, screen time and ‘other activity’ domains. No sociodemographic variations were found in total SB, but significantly higher study‐related SB were reported by students studying full time (p < .001) and who moved from their family home to study (p < .022). Study‐related SB contributed 36% of total SB, with students most sedentary during study having the highest total SB.ConclusionsThis study suggests university students have high levels of SB, primarily in the domains of study, screen time and other activities. SB reduction strategies in universities and targeting screen time, across various sociodemographic groups (e.g., gender, university enrolment status, and living arrangements), may be important in reducing SB in university students.So What?University students are highly sedentary and should be included in SB programs especially students studying full time and those who moved from their family home in the study domain.
A systematic review of early phase studies for children and young people with relapsed and refractory rhabdomyosarcoma: The REFoRMS‐SR project
Authors: Evans Connor , Shepherd Lucy , Bryan Gemma , Fulbright Helen , Crowther Scott , Wakeling Sara , Stewart Andy , Stewart Claire , Chisholm Julia , Gibson Faith , Phillips Bob , Morgan Jessica E. 
Published: December 2023

AbstractRhabdomyosarcoma is the commonest soft tissue sarcoma in children. Around one‐third of children with rhabdomyosarcoma experience relapse or have refractory disease, which is associated with a poor prognosis. This systematic review of early phase studies in pediatric relapsed/refractory rhabdomyosarcoma was conducted to inform future research and provide accurate information to families and clinicians making difficult treatment choices. Nine databases and five trial registries were searched in June 2021. Early phase studies of interventions for disease control in patients under 18 years old with relapsed/refractory rhabdomyosarcoma were eligible. No language/geographic restrictions were applied. Studies conducted after 2000 were included. Survival outcomes, response rates, quality of life and adverse event data were extracted. Screening, data extraction and quality assessment (Downs and Black Checklist) were conducted by two researchers. Owing to heterogeneity in the included studies, narrative synthesis was conducted. Of 16,965 records screened, 129 published studies including over 1100 relapsed/refractory rhabdomyosarcoma patients were eligible. Most studies evaluated systemic therapies. Where reported, 70% of studies reported a median progression‐free survival ≤6 months. Objective response rate was 21.6%. Adverse events were mostly hematological. One‐hundred and seven trial registry records of 99 studies were also eligible, 63 of which report they are currently recruiting. Study quality was limited by poor and inconsistent reporting. Outcomes for children with relapsed/refractory rhabdomyosarcoma who enroll on early phase studies are poor. Improving reporting quality and consistency would facilitate the synthesis of early phase studies in relapsed/refractory rhabdomyosarcoma (PROSPERO registration: CRD42021266254).
Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function
Authors: Abe Gabriela L. , Sasaki Jun‐Ichi , Tsuboi Ririko , Kohno Tomoki , Kitagawa Haruaki , Imazato Satoshi 
Published: December 2023

AbstractGuided bone regeneration (GBR) is a treatment strategy used to recover bone volume. Barrier membranes are a key component of GBR protocols, and their properties can impact treatment outcomes. This study investigated the efficacy of an experimental, slow‐degrading, bilayer barrier membrane for application in GBR using in vivo animal models. A synthetic copolymer of poly(lactic acid/caprolactone) (PLCL) was used to prepare a slow‐degrading bilayer membrane. The biodegradability of PLCL was evaluated by subcutaneous implantation in a rat model. The barrier function of the PLCL membrane was investigated in a rat calvaria defect model and compared with commercially available membranes composed of type I collagen (Col) and poly(lactic‐co‐glycolic acid) (PLGA). An alveolar bone defect model in beagle dogs was used to simulate GBR protocols to evaluate the bone regeneration ability of the experimental PLCL membrane. The PLCL membrane showed slow biodegradation, resulting in an efficient and prolonged barrier function compared with commercial materials. In turn, this barrier function enabled the space‐making ability of PLCL membrane and facilitated bone regeneration. In the alveolar bone defect model, significantly greater regeneration was achieved by treatment with PLCL membrane compared with Col and PLGA membranes. Additionally, a continuous alveolar ridge contour was observed in PLCL‐treated bone defects. In conclusion, the PLCL bilayer membrane is a promising biomaterial for use in GBR given its slow degradation and prolonged barrier function.
Engaging with the unknown: How Judaism enabled Freud's psychological discoveries
Authors: Jennings Jerry L. 
Published: December 2023

AbstractA large literature has formed around the question of how Freud's Jewishness and/or Judaism influenced his psychological discoveries and development of psychoanalytic theory and methods. The article organizes the literature into several core theses but brings new clarity and insight by applying two essential criteria to demonstrate an impact of Judaism on Freud's thinking: direct content and historical timing. First, there should be evidence that Freud incorporated actual content from Jewish sources, and second, this incorporation must have occurred during the most crucial period of Freud's early discovery, conceptualization, and development of psychoanalysis, roughly 1893–1910. Thus, for example, Bakan's well‐known theory that Freud studied Kabbala is completely negated by the absence of any evidence in the required time period. Part I reviews the literature on the influence of Freud's ethnic/cultural Jewish identity. Part II introduces the Judaic sacred literature, explores Freud's education in Judaism and Hebrew, and presents evidence that Freud had the motive, means, and resources to discover and draw from the “Dream Segment” of the Talmud—along with the traditional Judaic methods and techniques of textual exegesis. Freud then applied these same Judaic word‐centered interpretive methods—used for revealing an invisible God—to revealing an invisible Unconscious in four successive books in 1900, 1901, and 1905.
Harvest graft substitute for soft tissue volume augmentation around existing implants: A randomized, controlled and blinded multicenter trial
Authors: Clem Donald S. , McClain Pamela K. , McGuire Michael K. , Richardson Chris R. , Santarelli Greg A. , Schallhorn Rachel A. , Scheyer E. Todd , Gunsolley John C. , Morelli Thiago 
Published: December 2023

AbstractBackgroundUsing a single‐blind, randomized, controlled, multicenter, practice‐based clinical trial, a volume‐stable collagen matrix (VCMX) was compared with connective tissue graft (CTG) for soft tissue augmentation around existing dental implants.MethodsSixty patients (31 VCMX and 31 CTG) were included. The primary outcome was a soft tissue thickness change 3 mm below the gingival margin (GM). Secondary outcomes included clinical measures, such as keratinized tissue widths (KTw), probing pocket depths, and pink esthetic scores, and patient‐reported outcomes (PRO).ResultsThere were no significant differences between test and control patient demographics or clinical measures throughout the 1‐year study. VCMX “grafts” were by design larger than CTG, and surgery time was less (27% less, p = 0.0005). Three millimeters below the GM (primary endpoint), tissue thickness increase was noninferior for VCMX compared with CTG (0.93 ± 0.80 mm vs. 1.10 ± 0.51 mm, respectively), inferior (by 0.25 mm) at 1 mm, and noninferior at 5 mm. Postoperative pain was significantly less for VCMX patients (p < 0.0001), but all other PRO measures, including esthetics and satisfaction, improved similarly for both therapies.ConclusionsGiven the inclusion criteria for this study, namely soft tissue augmentation around existing implants with some evidence of KTw and minimal recession, VCMX provided soft tissue thickness and volume increases similar (noninferior) to CTG. Clinical measures and PRO were similar between therapies—site sensitivity and esthetics improved similarly for both therapies—but surgery time and pain following surgery were significantly less for VCMX.
The interaction between organizational communication and knowledge management: A systematic literature review
Authors: Cidade Daniela Firmino , Oliveira Mírian 
Published: December 2023

AbstractThe advance of digital technology has made it easier for organizations to connect with their stakeholders and increased the importance of communication departments, which are responsible for managing the knowledge held by the organization. This systematic review aims to explore how organizational communication (OC) and knowledge management (KM) intersect. In this research, a systematic literature review was conducted according to the PRISMA recommendations. The collected data underwent content analysis using open and axial coding. The indicators show that internal communication and knowledge sharing (KS) processes are the most frequently studied areas in relation to the interaction between OC and KM. However, a few studies have explored any other processes, highlighting the need for more research in this area. The few studies that examine the interaction between KM and OC tend to focus solely on KS within companies. However, this study reveals the potential for KS to be applied to the communication and relationships between organizations and their stakeholders.
Can biochar conserve soil moisture and improve soil properties for sustainable intensification of acid soils in the Eastern Indian Himalayas?
Authors: Idapuganti Ramkrushna Gandhiji , Das Anup , Sungoh Heipormi , Layek Jayanta , Mandal Sandip , Verma Bibhash Chandra , Lal Rattan , Rangappa Krishnappa , Babu Subhash , Hazarika Samarendra 
Published: December 2023

AbstractThe marginal Himalayan ecosystems have great potential for biochar application for conserving soil moisture, ameliorating soil acidity, improving soil fertility, and thus, contributing to sustainable intensification. Thus, the efficacy of biochar was tested along with nutrient management practices (NMP) on the performance of maize (Zea mays L.)‐French bean (Phaseolus vulgaris L.) as the emerging cropping system in an acid soil under rainfed hill ecosystem. The rainy season maize was grown with three levels of biochar (0, 2.5, and 5 Mg ha−1, applied only once in the first year), and four NMP (100% recommended dose of fertilizer [RDF] [80:60:40 N:P2O5:K2O kg ha−1], 75% RDF, 75% RDF + 4 Mg ha−1 farm yard manure [FYM], and 50% RDF) under minimum tillage. After harvesting of maize, French bean was grown under no‐till with four NMP (100% RDF [50:60:40 N:P2O5:K2O kg ha1], 75% RDF, 75% RDF + 4 Mg ha−1 FYM, and 50% RDF). The soil properties after 3 years viz., soil moisture, soil organic carbon (SOC), pH, and available N, P, and K status were significantly improved under 5 Mg ha−1 biochar than no biochar. Among the NMP, 75% RDF + FYM and 100% RDF had higher soil moisture, water infiltration, pH, SOC concentrations, and available N, P, and K status than others. The interaction effect of 5 Mg ha−1 biochar and 75% RDF + 4 Mg ha−1 FYM registered the highest SOC content (15.7 g kg−1). Available N was the highest in soil under 75% RDF + 4 Mg ha−1 FYM whereas, available P in soil under 100% RDF. Application of 5 Mg ha−1 biochar produced significantly the highest mean grain yield of maize and succeeding French bean. The combined application of 100% RDF and biochar 5 Mg ha−1 produced the highest maize equivalent yield. Thus, 5 Mg ha−1 biochar and application of recommended fertilizers are suggested for sustaining soil fertility and sustainable intensification of rainfed hill agriculture under acidic soil.
Effect of spatial and temporal “drought legacy” on dust sources in adjacent ecoregions
Authors: Eibedingil Iyasu G. , Gill Thomas E. , Kandakji Tarek , Lee Jeffrey A. , Li Junran , Van Pelt R. Scott 
Published: December 2023

AbstractDrought affects the occurrence and intensity of aeolian dust events in many ecoregions. This study investigated the effects of “drought legacy” (the cumulative temporal persistence of drought's consequences on the earth system) on dust generation, a topic which had not previously been evaluated. We investigated the potential dust/drought legacy relationship in the USA's Southern Great Plains and Chihuahuan Desert ecoregions over 14 years, including the 2011–2012 extreme drought, at spatial distances up to 100 km around dust point sources and for up to 5 years' drought history. At every temporal and spatial scale, drought levels associated with dust initiation points in the two ecoregions were significantly different. Chihuahuan Desert dust sources concentrated in areas of severe to extreme drought, while those in the Southern Great Plains, which experiences greater land use, spanned wider ranges of drought conditions. At short temporal scales of drought (1 week and 1 year), dust initiation in the Chihuahuan Desert was associated strongly with severe to exceptional drought conditions at all spatial extents, while Southern Great Plains dust sources were linked to lower drought intensities. For longer drought histories (the past 2 and 5 years), Chihuahuan Desert dust sources were connected with moderate to severe drought, while Southern Great Plains dust sources were linked to moderate drought, at all spatial extents. Drought's legacies, extending over multiple years and kilometer scales, are shown to have roles in subsequent dust events at regional scales, though they can be regionally modulated by land use practices and ecosystem characteristics.
Impediments to efficient land reallocation in agriculture: Multi‐agent simulation model of transaction costs and farm retirement
Authors: Ito Junichi 
Published: December 2023

AbstractThis study examines the effect of land exchanges among farm households (FHs) on agricultural sustainability and viability using a multi‐agent simulation model. The initial values of the model are fixed so that the simulation results might reproduce the sequence of land use pattern in Japanese agriculture. The novelty of this study is three‐fold. First, it quantitatively assesses the extent to which transaction costs incurred by lessors and lessees impede the sound development of land rental markets. Second, the simulation model considers inter‐regional heterogeneity in land use patterns and the interactive behavior of FHs regarding land exchanges. Third, the model elucidates the mechanisms by which the equilibrium land rent reaches zero and farmland is abandoned when some FHs retire from farming. Farmland abandonment has become a global phenomenon that has profoundly altered the traditional agricultural landscape in various countries. The present study suggests that the development of land rental markets associated with farm retirement alone does not strengthen agricultural production capacity at the national level. Particularly, if FH retirement progresses to the point where the equilibrium land rent drops to zero, farmland abandonment occurs, which threatens agricultural sustainability and viability. This study concludes that preventing farmland abandonment is a policy issue of the highest priority to ensure global food security and the sustainable development of agriculture.