bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric computational mapping analysis of Sekolah Indonesia Luar Negeri (SILN) and learning difficulties using VOSviewer
Authors: Yustiana Yusi Riksa , Ahlan Riksma Nurahmi Rinalti , Zakariyya Farhan 
Published: December 2023

Abstrak: Penelitian ini mengkaji perkembangan penelitian mengenai sekolah Indonesia luar negeri (SILN) dan kesulitan belajar melalui pendekatan bibliometrik dengan analisis pemetaan komputasional menggunakan VOSviewer. Penelitian ini bertujuan untuk dapat mengetahui pengembangan penelitian dan juga menjadi penelitian dasar. Data artikel diperoleh dari database Google Scholar menggunakan aplikasi publish or perish reference manager. Judul dan abstrak artikel digunakan untuk memandu proses pencarian dengan mengacu pada kata kunci “Sekolah Indonesia Luar Negeri” dan “Kesulitan Belajar” menggunakan VOSviewer. Masa studi yang digunakan sebagai bahan kajian adalah artikel terindeks Google Scholar selama 10 tahun terakhir (2013 s/d 2023). Hasil penelitian menunjukkan bahwa penelitian memiliki 7 cluster. Dari hasil pencarian, sebanyak 983 artikel relevan diterbitkan pada rentang tahun 2013 hingga 2023. Hasil penelitian menunjukkan bahwa peluang untuk penelitian pada sekolah Indonesia luar negeri dan kesulitan belajar masih memiliki peluang yang sangat tinggi karena belum ada penelitian langsung yang meneliti dan kemungkinan dikaitkan dengan istilah lain. Abstract: This research examines the development of research Sekolah Indonesia Luar Negeri (SILN) and learning difficulties through a bibliometric approach with computational mapping analysis using VOSviewer. This research aims to find out research development and also become basic research. Article data was obtained from the Google Scholar database using the publish or perish reference manager application. The title and abstract of the article are used to guide the search process by referring to the keywords " Sekolah Indonesia Luar Negeri " and "Learning Difficulties" using VOSviewer. The study period used as study material is articles indexed by Google Scholar during the last 10 years (2013 to 2023). The research results show that the research has 7 clusters. From the search results, a total of 983 relevant articles were published between 2013 and 2023. The research results show that the opportunity for research on Indonesian schools abroad and learning difficulties still has a very high chance because there has been no direct research that examines it and the possibility of being associated with other terms.
Predictors of Reduced Left Ventricle Global Longitudinal Strain One Year After COVID-19 Pneumonia
Authors: Yaroslavskaya E. I. , Gorbatenko E. A. , Krinochkin D. V. , Shirokov N. E. , Osokina N. A. , Migacheva A. V. , Petelina T. I. 
Published: December 2023

Aim To identify predictors of decreased left ventricular global longitudinal strain (LV GLS) using the method of speckle-tracking in gray scale one year after COVID-19-associated pneumonia in patients without ischemic heart disease (IHD), previous pulmonary embolism (PE), peripheral thrombosis, and atrial fibrillation (AF).Material and methods The study included 156 patients from the Prospective Registry of People After COVID-19-Associated Pneumonia, with optimal visualization quality according to echocardiography (EchoCG), without IHD, AF, history of pulmonary embolism (PE), and peripheral thrombosis. The patients underwent clinical examination in the hospital during the acute period and at 3 and 12 months after discharge from the hospital. To identify earlier predictors of LV GLS impairment, clinical, laboratory, and instrumental data obtained in the hospital and at 3 months of discharge were compared based on the presence of LV GLS impairment one year after discharge (43 patients with reduced LV GLS and 113 patients with normal LV GLS). An LV GLS value ≥18% was considered reduced.Results At 3 months after discharge from the hospital, LV GLS impairment was detected in 34 (21.8%) of 156 patients, and 12 months later, in 43 (27.6%; p=0.211) of 156 patients. In contrast to the group with normal LV GLS, the majority of the group with reduced LV GLS were men (74.4% vs. 37.2%; p=0.001). In this group, body mass index (BMI) was significantly higher (29.9±4.3 kg/m2 vs. 28.1±4.5 kg/m2; p=0.011), and biological (11.6% vs. 2.7%; p=0.024) and hormonal therapy was administered more frequently (38.1% vs. 22.3%; p=0.049). The final predictive model for LV GLS impairment included male gender (odds ratio (OR), 5.65; 95% confidence interval (CI), 1.22-14.37; p <0.001), BMI (OR, 1.11; 95% CI, 1.01-1.23; p=0.040), left ventricular end-systolic volume index (LVESVI) (OR, 1.10; 95% CI, 1.01-1.22; p=0.046) and right ventricular outflow tract (RVOT) acceleration time (OR, 0.98; 95% CI, 0.95-0.99; p=0.027).Conclusion One year after COVID-19-associated pneumonia, a decrease in LV GLS was observed in 27.6% of patients without IHD, AF, history of PE, and peripheral thrombosis and was associated with male gender, increased BMI and LVESVI, and shortened RVOT acceleration time as measured 3 months after discharge from the hospital. The decrease in LV GLS one year after discharge was not associated with the severity of the disease, length of stay in the hospital, or biological and hormonal therapy.
The Clinical Evolution of Diffuse Myocardial Fibrosis in Patients With Arterial Hypertension and Heart Failure With Mildly Reduced Ejection Fraction Treated by Olmesartan or Sacubitril / Valsartan
Authors: Shulzhenko L. V. , Pershukov I. V. , Batyraliev T. A. , Karben Z. A. , Gurovich O. V. , Fettser D. V. , Kuznetsova T. N. , Ivanenkova E. Yu. , Akbalaeva B. A. , Rayimbek uulu N. , Toygonbaev S. , Mansharipova A. T. , Seidalin A. O. , Zyablova E. I. , Kalmatov R. K. , Imetova Zh. B. , Vinogradskaia V. V. , Gaydukova E. V. 
Published: December 2023

Aim A 12-month evaluation of the potentialities of the angiotensin II receptor inhibitor olmesartan (Olme) and the angiotensin receptor and neprilysin inhibitor (ARNI) sacubitril/valsartan in patients with arterial hypertension (AH) and dyslipidemia in the dynamics of the following indicators of chronic heart failure (CHF): N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), LV global longitudinal strain (LV GLS) in diffuse myocardial fibrosis (MF) previously diagnosed by magnetic resonance imaging (MRI).Material and methods Olmesartan medoxomil (n=56) and sacubitril/valsartan (n=63) were used for 12 months in patients with hypertension, dyslipidemia and NYHA functional class II-III CHF with mid-range LVEF (CHFmrEF). MF was diagnosed by the following MRI criteria: late gadolinium enhancement and an increased proportion of extracellular matrix (33% or more). The frequency of persisting late gadolinium enhancement and the increased proportion of extracellular matrix (33% or more) was evaluated at 12 months; changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), NT-proBNP, and LV GLS were evaluated after 3, 6, and 12 months of follow-up.Results Baseline parameters did not differ between groups. The late gadolinium enhancement and increased proportion of extracellular matrix were present at baseline in all patients of both groups (100%; p=1.0). Already at 3 months, statistically significant decreases in SBP and DBP were observed in both groups. In addition, the LV GLS monitoring showed LV GLS significantly increased in both groups after 3 months and continued changing after 6 and 12 months. The NT-proBNP concentration significantly decreased in both groups already after 3 months and continued to decrease after 6 and 12 months. At 6 and 12 months, sacubitril/valsartan was superior to olmesartan in reducing SBP and NT-proBNP and in restoring LV GLS. At 12 months, the incidence of persisting, abnormal late gadolinium enhancement and increased proportion of extracellular matrix was significantly less in the ARNI group.Conclusion Olmesartan was demonstrated effective in the multi-modality therapy of CHFmrEF and MF in patients with AH and dyslipidemia. ARNI was superior to olmesartan in this regard, but further research of this issue is required.
Prevalence of cervical intraepithelial neoplasia and cervical carcinoma in a tertiary care hospital at Rajshahi
Authors: Naznin Mahmuda , Hossain M. Zahid , Saha Seema , Neela Farzana Ashrafi 
Published: December 2023

Background: Cervical intraepithelial neoplasia (CIN) is a precancerous cervical condition with the potential to develop into cervical carcinoma if untreated. While research on CIN and cervical carcinoma exists in various regions, the Rajshahi area lacks such investigations. Examining the prevalence of CIN and cervical carcinoma in this region is essential. This study aimed to assess the prevalence of CIN and cervical carcinoma in a tertiary care hospital at Rajshahi in Bangladesh.
Methods: This cross-sectional descriptive study was conducted at the department of pathology, Rajshahi medical college, and the department of gynaecology and obstetrics, Rajshahi medical college hospital, Rajshahi, Bangladesh from July 2019 to June 2022. A total of 1000 VIA test-positive cases of cervical lesions were enrolled as study subjects purposively. Data were processed and analyzed by the MS office tools.
Results: Cervical carcinoma was identified through cytological analysis in 4.6% of cases, with 7.6% exhibiting high-grade squamous intraepithelial lesions (HSIL) and 13.1% showing low-grade squamous intraepithelial lesions (LSIL). Through histopathological analysis, cervical carcinoma found in 5.3% of cases, CIN-grade III (CIN-III) in 7.1%, and CIN-II and CIN-I in 2.2%, 16.4% of cases, respectively. Human papillomavirus (HPV) vaccination rate was 0.70%.
Conclusions: The prevalence of CIN and cervical carcinoma in the Rajshahi region of Bangladesh is alarmingly high. These findings underscore the pressing need for the immediate implementation of a comprehensive vaccination and awareness development program for cervical carcinoma.
Attitudes and Perceptions of Filipino Clinicians and Pathologists towards the Autopsy as a Medical Tool
Authors: Acapulco-Gomez Kathrina Aseanne , Uson Irene 
Published: December 2023

Background. Globally, autopsy rates have been continually declining over the course of several years. Previous studies have shown that the perception of pathologists and clinicians may serve as significant factors which may affect the performance of autopsy and contribute to its decreased rate. This study was conducted to determine the attitudes and perceptions of Filipino clinicians and pathologists toward the autopsy as a medical tool.
Methodology. This is a cross-sectional descriptive survey of two groups of physicians. Forty-four (n = 44) pathologists nationwide and thirty-three (n = 33) clinicians from Central Visayas participated in the study. A total of seventy-seven (n = 77) physicians completed a survey using a standardized online questionnaire.
Results. Of the 77 respondents, 94% of clinicians and 75% of pathologists believed that autopsies could provide relevant findings that could change future clinical practice. Despite this, only 6% of clinicians and 20% of pathologists indicated that the number of autopsy cases in their institutions was sufficient. With regards to their practice, pathologists most strongly agreed (mean = 4.30) that material for medico-legal autopsies should be readily available for teaching and research. However, they most strongly disagreed (mean = 2.00) that residents receive adequate training in performing medico-legal autopsies. The two groups of physicians surveyed determined that there is a deficiency in the number of autopsy cases. This is further influenced by clinicians’ concerns about litigation, religious/superstitious beliefs, and the delay in releasing autopsy results. Furthermore, pathologists specified that performing autopsies was excessively time-consuming with an unjustifiable cost. Sixty-two percent of the pathologists signified more strongly than the clinicians that modern diagnostic techniques have diminished the need to perform hospital autopsies. Nonetheless, 86% of Filipino physicians acknowledged that the autopsy is an important medical tool that should be performed for patients with unknown diagnoses and unexpected death. The number of observed and/or performed autopsy cases was a major factor that affected the pathologists’ attitudes and perceptions toward autopsy.
Conclusion. In general, there is recognition of the autopsy’s usefulness as a medical tool among the pathologists and clinicians surveyed. However, the lack of cases referred for autopsy remains a challenge undermining the benefits that are derived from its performance.
A novel methylation site of SFRP1 Gene Promoter in colorectal cancer: Potential utility as biomarker for prognosis and immunotherapy
Authors: Shi Yanting , He Ti , Li Xiaofei , Zhou He , Wang Fang , Su Song , Liang Jie 
Published: December 2023

Abstract
The methylation level of the SFRP1 gene promoter is closely related to colorectal cancer. 205 stool samples were enrolled and were divided into positive and negative groups in the study. MassArray was used to screen the level of methylation on the SFRP1 gene promoter in the two groups. A random forest model was established to analyze and screen methylation sites of characteristic expression. A further 60 fecal samples were collected and divided into positive and negative groups to verify the specificity and sensitivity of the characteristic methylation sites by RT-PCR. TCGA database was used to analyze the relationship between tumor immunity and methylation sites in CRC patients. 12 differentially expressed MassArray detected methylation sites on SFRP1 promoter in colorectal cancer or adenoma stool specimens compared to normal. Random forest regression models built using the R package randomForest analysis (OOB error rate is 39.29%) located in the OOB error fastest changing area and have a good performance (accuracy: 0.757, sensitivity: 0.857, specificity: 0.696). The cg15839448, cg17816908 and cg14548509 showed better on specificity and sensitivity. Further, RT-PCR analysis showed that SFRP1_CpG_16.17.18 (cg17816908) performed best between the three CpG sites. The AUC of the ROC curve is 0.791, which was higher than the other two CpG sites. And cg17816908 is negatively correlated with prognosis and immune checkpoints with immunotherapy sensitivity in CRC patients. Our study demonstrated that SFRP1_CpG_16.17.18 (cg17816908) has a good clinical performance as a prognosis marker of colorectal cancer, and may provide a reference to immunotherapy in the clinic.
Patterns of childhood tuberculosis diagnosis in Ethiopia: A multicenter cross-sectional study
Authors: Usmael Kedir , Manyazewal Tsegahun , Mohammed Hussen , Yimer Getnet , Oljira Lemessa , Roba Kedir Teji , Hailemariam Tesfahunegn , Adjeme Tigist , Tesfaye Dagmawit , Bisrat Haileleul , Ngadaya Esther , Woldeamanuel Yimtubezinash 
Published: December 2023

Abstract
Background
Children share 12% of the global 10 million people infected with tuberculosis (TB) each year. Closing case detection gap in children remains difficult, with 56% of all children and 65% under-five with TB missed each year. We aimed to assess the patterns of childhood TB diagnosis and underlying determinants in Ethiopia when different TB diagnostic platforms are applied.
Methods
A multi-site, cross-sectional study was carried out in Ethiopia as part of the larger EXIT-TB study - evidence-based multiple focused integrated intensified TB screening package. Outpatient children aged ≤ 15 with cough of any duration seeking care at four healthcare facilities in Ethiopia were enrolled consecutively. Participants underwent sputum Xpert MTB/RIF and/or smear microscopy and posteroanterior chest X-ray (CXR), and their clinical and sociodemographic data were captured using a structured questionnaire. Data were analyzed using Stata version 23. Multiple regression model was computed to determine the factors that influence TB case detection, with a 95% confidence interval (CI) and p < 0.05 taken as statistically significant.
Results
A total of 438 children were enrolled. Of these, 399 had CXR examination of which 55 (13.8%) were suggestive of TB, 270 had Xpert MTB/RIF testing of which 32 (11.9%) were positive, and AFB smear microscopy was done for 51 children of which 2 (3.9%) were positive. Febrile children were more likely to be diagnosed with pulmonary TB than those without fever [aPR = 1.3, 95% CI (1.1–1.4)], and those with a TB contact history were more likely to be diagnosed with pulmonary TB than those with no such contacts [aPR = 1.2, 95% CI (1.1–1.3)]. Children from rural residences were more likely to be diagnosed with TB than those from urban residences [aPR = 1.3, 95% CI (1.1–1.5)].
Conclusion
The findings showed that clinical diagnosis remains an important method of TB diagnosis in children and the preferred choice to avert underdiagnosis. A more sensitive TB diagnostic method for children was symptom screening, followed by CXR and Xpert MTB/RIF assay or smear microscopy. Hence, an algorithm that combines clinical, CXR, and microbiological confirmatory tests can improve the rate of pulmonary TB diagnosis in children till more accurate and cost-effective diagnostic tools are accessible. Fever, weight loss, and TB contact history are highly associated with TB positivity rates in children.
Effects on major edaphic properties across various contexts: light drought vs. extreme drought
Authors: Meng Yu , Qiu Bing , Yu Zhilei , Yang Meijian , Xu Yingjun , Weng Baisha , Yan Denghua 
Published: December 2023

Abstract
Under climate change, there is a drastic increase in the frequency of drought events, which significantly impacts the biogeochemical processes in regional soil. However, the specific patterns of how different drought intensities affect the physicochemical and biological properties of soil remain unclear. Therefore, this study is based on the utilization of meta-analysis to investigate the impact patterns of drought, light drought, and extreme drought on crucial physicochemical and biological properties of soil under different conditions (soil depth, rhizosphere, experimental conditions, and land use types). The results indicate that: (1) During extreme drought, the variation in soil water content follows the pattern: surface (0-15cm) soil > shallow (15-45cm) soil, rhizosphere > non-rhizosphere, potted soil > field soil, cropland > grassland > forest. On the other hand, during light drought, the pattern is: surface (0-15cm) soil < shallow (15-45cm) soil, rhizosphere < non-rhizosphere, potted soil < field soil, cropland < forest < grassland. (2) Soil C:N ratio decreases during light drought, while soil AP (available phosphorus) and BG (β-1,4 glucosidase activity) activities decrease or are reduced during extreme drought. In terms of soil chemical properties under different conditions, extreme drought increases pH and MBC:MBN in shallow soil, non-rhizosphere, field soil, grassland, and forestland. Light drought decreases C:N ratio and BG activity in shallow soil, non-rhizosphere, field soil, and forest. (3) Extreme drought and light drought significantly decrease F:B (Fungal:Bacteria) ratio in shallow soil (15-45cm) by 119.6% and 217.4% respectively. They also increase F:B ratio in forestland and non-rhizosphere soil by 161.5% and 91.5% in the case of forestland, and 161.4% and 86.5% in the case of non-rhizosphere soil. Light drought significantly increases soil microbial diversity (Shannon index increase by 2.7%), while extreme drought significantly decreases soil microbial diversity (Shannon index decrease by 7.6%). This study contributes to the understanding of the impact of extreme drought and other drought events on regional soil ecosystems and provides scientific support for identifying the mechanisms through which extreme hydrological events affect soil biogeochemical processes. These findings are important for soil management and ecological conservation.
Selective Antimicrobial Effects of an Herbal Compound Rinse Against Multi-species Oral Biofilms
Authors: Tsai Yi-Wen C. , Siddiqui Danyal A. , Kotsakis Georgios A. 
Published: December 2023

Abstract
Background:
The growing utilization of oral rinses in dental and periodontal care has prompted the need for innovative products with selective antibacterial properties. This study evaluates the efficacy of an herbal compound rinse (StellaLife VEGA Oral Rinse, StellaLife Inc, IL) containing plant attenuations and propolis, in comparison to conventional antimicrobial oral rinses.
Materials and Methods:
Streptoccoccus oralis, Streptococcus gordonii DL1, Veillonella parvula, Fusobacterium nucleatum, and Porphyromonas gingivalis were cultured and treated with StellaLife VEGA Oral Rinse (SL), 0.12% chlorhexidine (CHX), and Listerine Cool Mint mouthwash. Planktonic bacterial growth was assessed through optical density measurements (OD600), and colony forming units (CFU) counts. A clinical ex vivo multi-species biofilm was used to evaluate antibiofilm effects through fluorescence biofilm tracking.
Results:
SL significantly inhibited the growth of F. nucleatum 12 hours after treatment and P. gingivalis 96 hours after treatment, while exhibiting lower toxicity toward commensal bacteria such as S. oralis, S. gordonii, and V. parvula compared to LIS or CHX. In the clinical ex vivo biofilm, StellaLife, CHX, and Listerine all showed significant antibiofilm effects, disrupting biofilm structure and reducing bacteria viability.
Conclusions:
SL’s selective action on oral bacteria, targeting pathogens while preserving commensal microbes, holds promise for selective preservation of eubiotic biofilms. This study demonstrates the potential of this herbal compound rinse as an effective aid to selectively combat particularly against periodontal pathogens. Additional clinical studies are warranted to validate these findings and explore their broader applications in oral health.
Post contrast three dimensional MP RAGE T1WI sequence compared to brain MRV (TOF study) in diagnosing brain sinus venous thrombosis
Authors: banihani maysoon , malabeh Qamar , shawaqfeh jameel , khawaldeh maher , AlHazaimeh Mohammad 
Published: December 2023

Abstract

Aim : To compare the accuracy of MRV TOF and post contrast MP-RAGE sequences in diagnosis of cerebral sinus venous thrombosis .
Methods and materials : After all informed consents were obtained and upon ethical committee approval from the ethical committee in Joradanian Royal medical services in Amman we perform this study as a retrospective study done on 50 patients with cerebral sinus venous thrombosis with 50 pateints control group done at king Hussein medical center in Amman Jordan . The guidelines and regulations of studies conducted in Royal medical services were followed . 68 females and 32 males with age range between 19 and 52 years All patients underwent brain MRI for evaluation of cerebral sinus thrombosis , all studies were done on seimens skyra 3 tesla machine with standardized protocol including 2 D TOF MRV , axial T2WI , axial FLAIR , Axial T1 , SWI and diffusion weighted images along with 3D MP-RAGE post contrast . Images were reviewed by two well experienced neuroradiologists ( Maysoon and Qamar ) in separate sessions , each MRI sequence was reported separately without knowing patients name or clinical history . The results for T2 WI , SWI , MRV TOF and MP-RAGE post contrast were reported . We used a confidence level score to standardize the results Then the results were analyzed using simple statistical methods .