bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Extremely High Insulin-Mimetic Activity of Bis(1,4-dihydro-2-methyl-1-phenyl- 4-thioxo-3-pyridinolato)zinc(II) Complex
Authors: Katoh Akira , Tsukahara Takeshi , Saito Ryota , Ghosh Kallol K , Yoshikawa Yutaka , Kojima Yoshitane , Tamura Asuka , Sakurai Hiromu 
Published: September 2002

Abstract
Vanadyl and zinc(II) complexes with VO(O2S2) and Zn(O2S2) coordination mode, respectively, were synthesized. Among them, bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) complex exhibited an extremely high insulin-mimetic activity (IC50=0.04 mM when IC50 value of a positive control, VOSO4 was estimated to be 1.0 mM) compared to vanadyl and zinc(II) complexes reported previously.
Steric Effect is an Additional Possible Cause of Blue-shifting Hydrogen Bonds
Authors: Fang Ying , Fan Jian-Miao , Liu Lei , Li Xiao-Song , Guo Qing-Xiang 
Published: September 2002

Abstract
A novel simple example was found that at least sometimes the steric effect could cause a blue-shifting hydrogen bond, which indicates that Hobza’s recent theory about the origin of the blue-shifting hydrogen bond is not complete.
A Novel High-Pressure NMR Cell Consisting of Double Tube Structure for the Convenient On-Line Measurements
Authors: Umecky Tatsuya , Kanakubo Mitsuhiro , Ikushima Yutaka , Saito Norio , Yoshimura Junko , Yamazaki Hiromi , Yana Junzo 
Published: September 2002

Abstract
We have newly developed a high-pressure polymer NMR cell, which has a versatile use for both batchwise and on-line operations. The high-pressure cell withstands temperatures and pressures, at least, up to 373 K and 35 MPa, respectively. It was demonstrated that the sample solutions of not only viscous carbon tetrachloride but also non-viscous subcritical carbon dioxide smoothly flow in and out at moderate flow rates by measuring the flow rate dependence of the longitudinal relaxation times.
Mercuric Triflate-TMU Catalyzed Hydration of Terminal Alkyne to give Methyl Ketone under Mild Conditions
Authors: Nishizawa Mugio , Skwarczynski Mariusz , Imagawa Hiroshi , Sugihara Takumichi 
Published: September 2002

Abstract
Herein developed mercuric triflate-TMU catalyzed hydration of terminal alkyne is a mild procedure to give methyl ketone in excellent yield with high chemoselectivity. By using 0.05 eq of Hg(OTf)2·(TMU)2 and 3 eq of water, hydration takes place at a reasonable rate in acetonitrile.
A Novel Oxidative Transformation of α-Aminonitriles to Amides
Authors: Yokoshima Satoshi , Kubo Tetsuji , Tokuyama Hidetoshi , Fukuyama Tohru 
Published: September 2002

Abstract
A novel oxidative transformation of α-aminonitriles to amides is reported. Oxidation of α-aminonitriles with peracid, followed by basic treatment affords, amides in good yields. A mechanistic aspect of this transformation is also discussed.
Tandem Cyclizations of Benzopyranylidenetungsten(0) Complexes with Electron-Rich Dienes for the Stereoselective Synthesis of Polycyclic Carbon Skeletons
Authors: Kusama Hiroyuki , Shiozawa Fumiyasu , Shido Masahide , Iwasawa Nobuharu 
Published: September 2002

Abstract
o-Quinodimethanes, generated by the Diels-Alder reactions of benzopyranylidenetungsten(0) complexes with electron-rich dienes, further undergo intramolecular cyclizations to afford novel polycyclic compounds.
Phosphine/Lewis Acid Mediated Reformatsky-type Reaction of α-Bromoketone or -Thioester Derivatives
Authors: Hashimoto Yukihiko , Kikuchi Satoshi 
Published: September 2002

Abstract
The combination of (o-tolyl)3P/TiCl4 effectively promoted the Reformatsky-type reaction of α–bromoketone or -thioester derivatives with various aldehydes, and the corresponding β–hydroxy carbonyl compounds were obtained in good yield with high diastereoselectivity.
A Facile Synthetic Method for Indolic Enamides
Authors: Kuramochi Kouji , Osada Yuko , Kitahara Takeshi 
Published: September 2002

Abstract
We report a facile method for preparing enamides, based on the Curtius rearrangement and acylation of alkenylcarbamate. Using this approach, a total synthesis of coscinamide B, a bis indolic enamide, was achieved.
An Efficient Synthesis of the Piperazinone Fragment of Pseudotheonamide A1 via a Stereoselective Intramolecular Michael Ring Closure
Authors: Shioiri Takayuki , Irako Naoko 
Published: September 2002

Abstract
The stereoselective intramolecular Michael ring closure of the dipeptide efficiently gives the piperazinone fragment of pseudotheonamide A1, a serine protease inhibitor from the marine sponge Theonella swinhoei.
Kinetics of Hydroxyl Radical Reaction with CF2ClOCHO: A Theoretical Investigation
Authors: K. Chandra Asit , Uchimaru Tadafumi , Sugie Masaaki , Sekiya Akira 
Published: September 2002

Abstract
The rate constant for the hydrogen abstraction reaction between CF2ClOCHO and OH radical has been calculated for the first time by using the modified ab initio G2(MP2) and standard transition state theories. The Arrhenius equation for the rate constant, ktotal, within the temperature range of 250 K to 450 K is estimated to be 7.1×10-13exp(-845/T) cm3 molecule-1 s-1.
A Novel Reaction Promoted by Hydrogen Polyiodides (HI2n+1): Cyclization of 1-(1H-3-Indolyl)-4-(methylthio)-2-(p-tolylsulfonyl)-1,3-butadienes Accompanied with 1,2-Sulfonyl Migration
Authors: Matsumoto Shoji , Kishimoto Takuya , Ogura Katsuyuki 
Published: September 2002

Abstract
Reaction of 1-(1H-3-indolyl)-4-(methylthio)-2-(p-tolylsulfonyl)-1,3-butadienes (1) with iodine was accompanied with an unusual 1,2-migration of the sulfonyl group to give an abnormal cyclization product (3). This 1,2-migration reaction was brought about by the action of hydrogen polyiodides that are produced from excess I2 and EtSH. It is noteworthy that the reaction of 1 with HI resulted in formation of a normal product (2).
Novel π-Conjugated Cyclophanes: Magazine Rack Molecules
Authors: Orita Akihiro , Jiang Lasheng , Tsuruta Madoka , Otera Junzo 
Published: September 2002

Abstract
Synthesis of cyclophanes having alternating arylene-ethynylene as well as-ethenylene arrays is described. It is disclosed that these compounds are chiral on the basis of X-ray analysis and fluxional in solution on the basis of NMR spectra.
Alkenyldimethyl(2-thienyl)silanes, Excellent Coupling Partner for the Palladium-Catalyzed Cross-Coupling Reaction
Authors: Hosoi Kazushi , Nozaki Kyoko , Hiyama Tamejiro 
Published: September 2002

Abstract
Introduction of a 2-thienyl group to the silicon atom of alkenylsilanes promoted the cross-coupling reaction with aryl halides mediated by tetrabutylammonium fluoride and a palladium catalyst. The reaction proceeded under extremely mild conditions to afford arylalkenes in high yields.
The First Total Synthesis of (±)-Napyradiomycin A1
Authors: Tatsuta Kuniaki , Tanaka Yoshiki , Kojima Masazumi , Ikegami Hiroshi 
Published: September 2002

Abstract
(±)-Napyradiomycin A1 has been stereoselectively synthesized through a tandem Michael-Dieckmann type reaction and the introduction of a side chain and two chlorine atoms onto the pyranonaphthoquinone core.
Palladium-Catalyzed Asymmetric Alkylation of 2,3-Alkadienyl Phosphates. Synthesis of Optically Active 2-(2,3-Alkadienyl)malonates
Authors: Imada Yasushi , Ueno Katsuya , Kutsuwa Koji , Murahashi Shun-Ichi 
Published: September 2002

Abstract
Asymmetric alkylation of 2,3-alkadienyl phosphates with soft carbon nucleophiles proceeds efficiently in the presence of palladium complex catalyst bearing MeOBIPHEP or BINAP ligand to give optically active functionalized allenes up to 90% ee.
Homoaldol and Aldol Reactions from Common Enolates and Oxiranes: Reaction of Reductively Generated Chromium Enolates through Cationic Rearrangement
Authors: Hojo Makoto , Sakata Kyosuke , Maimaiti Xiamuxikamaer , Ueno Junya , Nishikori Hisashi , Hosomi Akira 
Published: September 2002

Abstract
Enolates generated from α-bromo esters by the reduction with “Bu6CrLi3” react with oxiranes to afford γ-hydroxy esters and β-hydroxy esters, depending on the Lewis acid used as a promoter.
Synthesis of 3,4-Dihydro-2H-pyrroles from γ,δ-Unsaturated Ketone O-Acetyloximes
Authors: Yoshida Masayuki , Kitamura Mitsuru , Narasaka Koichi 
Published: September 2002

Abstract
3,4-Dihydro-2H-pyrroles were synthesized from γ,δ-unsaturated ketone O-acetyloximes by treatment with acetic acid and 1,4-cyclohexadiene in the presence of a catalytic amount of 1,5-naphthalenediol. During the cyclization, syn-anti isomerization of the O-acetyloximes easily occured and so, both stereoisomers of oximes could be employed.
Carbozincation of Dipolar Trimethylenemethane. A New Route to Functionalized Organozinc Reagents
Authors: Nakamura Masaharu , Yoshikai Naohiko , Nakamura Eiichi 
Published: September 2002

Abstract
Dipolar trimethylenemethane species, thermally generated from 2,2-dialkoxy-1-methylenecyclopropane, reacts with a dialkylzinc reagent to generate an allylic zinc reagent, which then reacts in situ with a carbonyl compound to give a hydroxy acetal product as the result of coupling of the three reactants.
Stereoselective Synthesis of Cyclic Ethers by SmI2-Induced Reductive Intramolecular Cyclization
Authors: Matsuo Goh , Kadohama Hitomi , Nakata Tadashi 
Published: September 2002

Abstract
The highly stereoselective syntheses of 2,3-trans-3-hydroxy-tetrahydropyran and oxepane were achieved by the SmI2-induced reductive intramolecular cyclizations from acyclic compounds having an aldehyde and a β-alkoxyacrylate. The syntheses of tetrahydrofuran, oxocane, and oxocene were also accomplished.
A Facile Method for Synthesis of 1,2-Oxazoline Derivative of N-Acetylglucosamine Promoted by Potassium Fluoride
Authors: Shoda Shin-ichiro , Izumi Ryuko , Suenaga Masako , Saito Kenji , Fujita Masaya 
Published: September 2002

Abstract
A potassium fluoride-promoted intramolecular cyclization reaction of 2-acetamido-2-deoxy-α-D-glucopyranosyl chloride took place smoothly, giving the corresponding 1,2-oxazoline derivative in good yield. Potassium fluoride behaves as a nucleophile for anomerization of the glycosyl chloride as well as an acid captor to scavenge the protonic acid liberated. This is an extremely practical method for preparation of sugar oxazoline derivatives with simple experimental procedures.
A New Method for the Synthesis of Stannyl Ethers by Acid-Catalyzed Reaction of Alcohols with Allyltributylstannane
Authors: Yamago Shigeru , Yamada Takeshi , Nishimura Ryuji , Ito Hiroki , Mino Yosuke , Yoshida Jun-ichi 
Published: September 2002

Abstract
Stannyl ethers are prepared by triflic acid-catalyzed reaction of alcohols with tributylstannane or allyltributylstannane at room temperature. The stannyl ethers thus prepared can be successfully used for the β-bromogycoside-mediated glycosylation reactions.
Efficient Lipase-catalyzed Enantioselective Acylation under Reduced Pressure Conditions in an Ionic Liquid Solvent System
Authors: Itoh Toshiyuki , Akasaki Eri , Nishimura Yoshihito 
Published: September 2002

Abstract
Lipase-catalyzed transesterification was demonstrated using methyl esters as acyl donors under reduced pressure in an ionic liquid ([bmim]PF6) solvent system. The transesterification of 5-phenyl-1-penten-3-ol took place smoothly under reduced pressure at 27 hPa at 40 °C when methyl phenylthioacetate was used as acyl donor in [bmim]PF6, and we succeeded in obtaining the corresponding acylated compound in optically pure form; this makes it possible to use lipase repeatedly because there was no drop in the reaction rate despite three repetitions of the process.
Anionic Ring-Opening Polymerization of Cyclic Thiocarbonates Containing Norbornene and Norbornane Groups Undergoing Volume Expansion on Polymerization
Authors: Kakimoto Keiichiro , Nemoto Nobukatsu , Sanda Fumio , Endo Takeshi 
Published: September 2002

Abstract
Six-membered cyclic thiocarbonate derivatives, 5,5-(bicyclo[2.2.1]hept-2-en-5,5-ylidene)-1,3-dioxane-2-thione (1) and 5,5-(bicyclo[2.2.1]heptan-5,5-ylidene)-1,3-dioxane-2-thione (2) underwent anionic ring-opening polymerization initiated by 1,8-diazabicyclo[5.4.0]-7-undecene (DBU) to afford polythiocarbonates accompanying 12.3 and 12.6% volume expansion, respectively.
Nucleophilic Allylation-Heterocyclization via Bis-π-allylpalladium Complexes: Synthesis of Five- and Six-Membered Heterocycles
Authors: Bao Ming , Nakamura Hiroyuki , Inoue Akihiko , Yamamoto Yoshinori 
Published: September 2002

Abstract
The reaction of the allylic halides 5–9 having an aldehyde or an imine moiety in the molecule with allyltributylstannane proceeded smoothly in the presence of Pd2•dba3•CHCl3 (5 mol%) in DMF or THF, giving the corresponding heterocycles 10–14 in good to high yields. The Stille coupling product was not obtained under these reaction conditions.
A New Silyl Ether-Type Linker Useful for the Automated Synthesis of Oligonucleotides Having Base-Labile Protective Groups
Authors: Kobori Akio , Miyata Kenichi , Ushioda Masatoshi , Seio Kohji , Sekine Mitsuo 
Published: September 2002

Abstract
A new silyl-type linker for the automated solid-phase synthesis of oligodeoxynucleotides was developed. A hydrosilane-type reagent for introduction of the silyl linker was synthesized in an overall yield of 50% from 1,4-dibromobenzene. By using this linker, an oligonucleotide having base-labile protecting groups could be isolated from the controlled pore glass under neutral conditions.
An Intriguing Effect of Polymer-Bound Lithium Amides in Catalytic Enantioselective Rearrangement of meso-Epoxides Mediated by Chiral Lithium Amides
Authors: Asami Masatoshi , Seki Atsushi 
Published: September 2002

Abstract
Polymer-bound lithium dialkylamides were prepared from the corresponding polymer-bound amines and butyllithium. The reagent was successfully employed as an in situ regenerating agent of a chiral lithium amide in a catalytic enantioselective rearrangement of meso-epoxides, and chiral allylic alcohols were obtained in up to 95% ee.
Highly Terminal-Selective Epoxidation of Linolenic Acid with an Amphiphilic Iron Porphyrin Catalyst Casted in Bilayer Membranes
Authors: Naruta Yoshinori , Goto Masa-oki , Tawara Toshifumi , Tani Fumito 
Published: September 2002

Abstract
An amphiphilic iron porphyrin having four hexadecanoic acid chains on each face of the porphyrin was prepared and the catalytic epoxidation of linolenic acid with the heme-casted bilayer membranes was achieved in high regioselectivity at the terminal double bond of the substrate. The orientation of the porphyrin ring in the membrane was determined to be parallel to the aqueous-bilayer interface by means of ESR.
Enantioselective Alkylation of Aldehydes with Diethylzinc Using a New Catalyst System, ((R)-Thiolan-2-yl)diphenylmethanol and Metal Alkoxides
Authors: Shiina Isamu , Konishi Katsuhiko , Kuramoto Yu-suke 
Published: September 2002

Abstract
Various optically active secondary alcohols are obtained by asymmetric alkylation of aldehydes with diethylzinc by way of a new catalyst system, ((R)-thiolan-2-yl)diphenylmethanol and several metal alkoxides. The transition states are also discussed in terms of experimental results and theoretical calculation.
Nanoporous Solid Acid Catalyst for the Diels-Alder Reaction of 1,3-Dienes with Acrylates
Authors: Onaka Makoto , Hashimoto Naoki , Yamasaki Ryota , Kitabata Yasuyoshi 
Published: September 2002

Abstract
Nanoporous aluminosilicate, Al-HMS with a high aluminum content, strong acidity, and nanoporosity was found to catalyze the Diels-Alder reaction of 1,3-dienes with methacrylate and acrylate, and turned out to be a green alternative to homogeneous acid catalysts.
Asymmetric Autocatalysis of Pyrimidyl Alkanol Induced by Optically Active 1,1′-Binaphthyl, an Atropisomeric Hydrocarbon, Generated from Spontaneous Resolution on Crystallization
Authors: Sato Itaru , Osanai Shunji , Kadowaki Kousuke , Sugiyama Tadashi , Shibata Takanori , Soai Kenso 
Published: September 2002

Abstract
An atropisomeric hydrocarbon, (R)-1,1′-binaphthyl, acts as a chiral initiator of asymmetric autocatalysis of pyrimidyl alkanol in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde to afford (S)-5-pyrimidyl alkanol 2 with 96% ee. On the other hand, in the presence of (S)-1,1′-binaphthyl, the reaction affords (R)-2 with 94% ee.
Highly Z-Selective Synthesis of Disubstituted α,β-Unsaturated Cyanides and Amides Using 10-P-5 Wittig Type Reagents
Authors: Kojima Satoshi , Kawaguchi Kazuhiro , Matsukawa Shiro , Uchida Keiichiro , Akiba Kin-ya 
Published: September 2002

Abstract
Phosphoranes (10-P-5) bearing cyanomethyl, acetamide, and N,N-dimethylacetamide groups were examined for Wittig type reactions. All three reacted to give the corresponding olefins. The reaction of the cyanomethyl reagent with aldehydes gave α,β-unsaturated cyanides with high Z-selectivity in the case of aliphatic aldehydes (Z:E=94:6 to 99:1). On the other hand, the reactions of the two amide reagents with aldehydes yielded α,β-unsaturated amides with high Z-selectivity for both aromatic and aliphatic aldehydes (Z:E=99:1 to &gt;99:&lt;1).
Tertiary Amine-Accelerated Allylgallation of Terminal Alkynes
Authors: Takai Kazuhiko , Ikawa Yoshito , Ishii Keijiro , Kumanda Makoto 
Published: September 2002

Abstract
Allylic gallium sesquibromides prepared by reduction of allylic bromides with gallium metal in the presence of a catalytic amount of indium, add to terminal alkynes with the aid of a tertiary amine to give 1,4-dienes.
Preparation of Porphyrin-stoppered Rotaxane Aiming at Immobilization on Substrate
Authors: Asakawa Masumi , Ikeda Taichi , Yui Nobuhiko , Shimizu Toshimi 
Published: September 2002

Abstract
The porphyrin-stoppered rotaxane was prepared from dibenzo-24-crown-8 (DB24C8) and the secondary ammonium ion derivative end-capped by the axial coordination of rhodium(III) tetra-(3,5-di-tert-butylphenyl) porphyrin [TBPP Rh(III) Cl]. This rotaxane molecule was designed aiming at the immobilization on a substrate and the analysis of the physicochemical properties as a single molecule.
Synthesis, Characterization of a Novel Compound SnEr2O4
Authors: Zhang Yong , Zhang Ke Li , Jia Man Ke , Tang Hao , Sun Ju Tang , Yuan Liang Jie 
Published: September 2002

Abstract
A novel compound, a rare earth complex oxide SnEr2O4 was synthesized by the thermal decomposition of its oxalate precursor prepared by Rheological Phase Reaction Method. TG, IR, XRD and XPS were used to prove the formation of the compound SnEr2O4. The structure of SnEr2O4 was defined by Rietveld analysis. SnEr2O4 is cubic, Pm3m, a=7.3735 Å, V=400.88 Å3, Z=4, Dx=8.573 g/cm3, Dm=8.2 g/cm3.
Acceleration of Hydrolysis of Acetylsalicylic Acid in AOT/Supercritical Ethane Reverse Micelles
Authors: Shervani Zameer , Ikushima Yutaka 
Published: September 2002

Abstract
In situ UV-vis spectroscopy has been applied to study the hydrolysis of acetylsalicylic acid, as a model reaction, in sodium bis(2-ethylhexyl)sulfosuccinate (AOT)/supercritical ethane reverse micelles in the presence of imidazole as a catalyst. A 55-fold increase in the rate constant was observed in AOT/supercritical ethane micelles compared to the reaction carried out in aqueous buffer medium. The promotion of hydrolysis in the micelles as compared to aqueous solution has originated from compartmentalization of water-soluble reactant and the catalyst in the aqueous core of micelles.
Ni(0)-Catalyzed Bismetallative Cyclization of 1,3-Diene and a Tethered Aldehyde in the Presence of Bu3SnSiMe3
Authors: Sato Yoshihiro , Saito Nozomi , Mori Miwako 
Published: September 2002

Abstract
Ni(0)-Catalyzed bismetallative cyclization of 1,3-diene and a tethered aldehyde in the presence of Me3SiSnBu3 gave the corresponding cyclized product, having an allylstannyl group in the side chain, which could be used as an allylstannane in a coupling reaction with benzaldehyde.
Electrochemical Change of the Photonic Stop Band of the Ordered Macroporous WO3 Films
Authors: Sumida Takayuki , Wada Yuji , Kitamura Takayuki , Yanagida Shozo 
Published: September 2002

Abstract
Three-dimensional macroporous tungsten trioxide (WO3) was electrochemically prepared by using the polystyrene opal as a template. The photonic stop band of the porous WO3 film could be changed when the WO3 was intercalated with lithium cation by the electrochemical method. The change of the stop band was attributed to the change of the refractive indices accompanied with the electrochromism of WO3.
A Catalytic Aldol Reaction between Ketene Silyl Acetals and Aldehydes Promoted by Lithium Amide under Non-acidic Conditions
Authors: Fujisawa Hidehiko , Mukaiyama Teruaki 
Published: September 2002

Abstract
A catalytic aldol reaction between trimethylsilyl enol ethers and aldehydes by using lithium diphenylamide, a Lewis base catalyst, in DMF or pyridine solvent proceeded smoothly to afford the corresponding aldols under mild conditions.
Reversible Formation of Nanoparticles by Thermoresponsive Dehydroalanine Polymer: Poly(N-isobutyryldehydroalanine methyl ester)
Authors: Tezuka Yoshihiko , Bando Yoshitaka , Tanaka Hitoshi 
Published: September 2002

Abstract
Two kinds of dehydroalanine monomers, N-isobutyryl dehydroalanine (iBDHA) and its methyl ester (iBDHAM), were synthesized and their homopolymers were prepared by free radical polymerization. While poly(iBDHA) did not show any phase transition in water, poly(iBDHAM) exhibited the lower critical solution temperature (LCST) at 19 °C to form colloidal dispersion of nanoparticles with 60 nm diameter above the LCST. This nanoparticle formation was thermoreversible.
Mesomorphic Properties of Bis(5-alkoxy-2-aminotroponato)coppers and Their N, N-Dimethyl Derivatives
Authors: Mori Akira , Yamamoto Shin-ichi , Takemoto Manabu , Ujiie Seiji 
Published: September 2002

Abstract
Unsymmetrical bis(5-alkoxy-2-aminotroponato)coppers showed tilted smectic C and G/J phases due to the alignment of the outboard dipole moment. Furthermore, their N,N-dimethyl derivatives had nematic and smectic A phases with low transition temperatures due to the reduction of the lateral overlapping and the steric repulsion of the methyl groups.
Synthesis and X-ray Structures of Rhodium Complexes of N21, N22-Bridged Porphyrin
Authors: Setsune Jun-ichiro , Yamauchi Takashi , Tanikawa Sachiko 
Published: September 2002

Abstract
(η4-1,5-Cyclooctadienyl)rhodium(I) complex with a bidentate N21, N22-bridged porphyrin ligand was prepared. The η4-1,5-cyclooctadiene ligand was easily replaced by carbon monoxide to give the corresponding (dicarbonyl)rhodium(I) porphyrin. The structures of these two complexes were proven by X-ray crystallography.
Enhancement of Surface Plasmon Resonance Sensing for DNA Hybridization Using Colloidal Au Attached Probe DNA
Authors: Yamaguchi Akira , Juodkazis Saulius , Matsuo Shigeki , Misawa Hiroaki 
Published: September 2002

Abstract
In this study, we demonstrate that the Au particle modified probe DNA monolayer can enhance the surface plasmon resonance (SPR) signal for measuring hybridization of unlabeled DNA molecules. The Au particles adsorbed on single stranded (ss)- and double stranded (ds)-DNA monolayers have different optical interaction with surface of Au thin film, and this difference induces the enhancement of the SPR signal.
Highly Stereoselective Radical Reduction of α-Bromo-α-fluoro-β-hydroxy Esters with Tributyltin Hydride Leading to threo-α-Fluoro-β-hydroxy Esters
Authors: Mima Kazuhide , Ishihara Takashi , Kuwahata Saki , Konno Tsutomu , Yamanaka Hiroki 
Published: September 2002

Abstract
α-Bromo-α-fluoro-β-hydroxy esters, prepared as isomeric mixtures by the zinc-mediated coupling reaction of dibromo-fluoroacetate with aldehydes at -20 °C, were successively treated with trimethylaluminium at -15 °C for 0.5 h and with tributyltin hydride in the presence of a catalytic amount of triethylborane at -15 °C for 4 h or at -78 °C for 6 h to give preferentially the threo-isomers of the corresponding α-fluoro-β-hydroxy esters in good yields.