bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in physical performance, body composition and physical training during military operations: systematic review and meta-analysis
Authors: Pihlainen K. , Santtila M. , Nindl B. C. , Raitanen J. , Ojanen T. , Vaara J. P. , Helén J. , Nykänen T. , Kyröläinen H. 
Published: December 2023

AbstractSystematic review and meta-analysis applying PRISMA guidelines with a PICOS format was constructed to provide an overview of changes in physical performance, body composition and physical training in soldiers during prolonged (≥ 3 months) military operations. Twenty-four studies out of the screened 4431 records filled the inclusion criteria. A small decrease in endurance performance was the most consistent finding (Hedge's g [g] − 0.21, 95% CI − 0.01 to − 0.41) while small overall increases in maximal strength of the lower (g 0.33, 95% CI 0.16–0.50) and upper body (g 0.33, 95% CI 0.19–0.46) were observed. In addition, small increases in strength endurance (push-up, g 0.34, 95% CI 0.15–0.52; sit-up g 0.26, 95% CI 0.07–0.44) were observed. The overall changes in body composition were trivial. Heterogeneity in the outcome variables varied mainly between low to moderate. Large inter-individual variations were observed in physical training volume, including decrements especially in endurance training frequency and volume. A reduction in total training load was often associated with negative changes in body composition and physical performance according to the principle of training specificity. Individuals with higher initial fitness level were more susceptible to decrements in their physical performance during operation.
Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels
Authors: Sprague Jared M. , Yekkirala Ajay S. , Singh Bhagat , Tochitsky Ivan , Stephens Michael , Viramontes Octavio , Ivanis Jelena , Biscola Natalia P. , Havton Leif A. , Woolf Clifford J. , Latremoliere Alban 
Published: December 2023

AbstractTRPV1 is an ion channel that transduces noxious heat and chemical stimuli and is expressed in small fiber primary sensory neurons that represent almost half of skin nerve terminals. Tissue injury and inflammation result in the sensitization of TRPV1 and sustained activation of TRPV1 can lead to cellular toxicity though calcium influx. To identify signals that trigger TRPV1 sensitization after a 24-h exposure, we developed a phenotypic assay in mouse primary sensory neurons and performed an unbiased screen with a compound library of 480 diverse bioactive compounds. Chemotherapeutic agents, calcium ion deregulators and protein synthesis inhibitors were long-acting TRPV1 sensitizers. Amongst the strongest TRPV1 sensitizers were proteasome inhibitors, a class that includes bortezomib, a chemotherapeutic agent that causes small fiber neuropathy in 30–50% of patients. Prolonged exposure of bortezomib produced a TRPV1 sensitization that lasted several days and neurite retraction in vitro and histological and behavioral changes in male mice in vivo. TRPV1 knockout mice were protected from epidermal nerve fiber loss and a loss of sensory discrimination after bortezomib treatment. We conclude that long-term TRPV1 sensitization contributes to the development of bortezomib-induced neuropathy and the consequent loss of sensation, major deficits experienced by patients under this chemotherapeutic agent.
Microbial gene expression analysis of healthy and cancerous esophagus uncovers bacterial biomarkers of clinical outcomes
Authors: Schäffer Daniel E , Li Wenrui , Elbasir Abdurrahman , Altieri Dario C , Long Qi , Auslander Noam 
Published: December 2023

AbstractLocal microbiome shifts are implicated in the development and progression of gastrointestinal cancers, and in particular, esophageal carcinoma (ESCA), which is among the most aggressive malignancies. Short-read RNA sequencing (RNAseq) is currently the leading technology to study gene expression changes in cancer. However, using RNAseq to study microbial gene expression is challenging. Here, we establish a new tool to efficiently detect viral and bacterial expression in human tissues through RNAseq. This approach employs a neural network to predict reads of likely microbial origin, which are targeted for assembly into longer contigs, improving identification of microbial species and genes. This approach is applied to perform a systematic comparison of bacterial expression in ESCA and healthy esophagi. We uncover bacterial genera that are over or underabundant in ESCA vs healthy esophagi both before and after correction for possible covariates, including patient metadata. However, we find that bacterial taxonomies are not significantly associated with clinical outcomes. Strikingly, in contrast, dozens of microbial proteins were significantly associated with poor patient outcomes and in particular, proteins that perform mitochondrial functions and iron-sulfur coordination. We further demonstrate associations between these microbial proteins and dysregulated host pathways in ESCA patients. Overall, these results suggest possible influences of bacteria on the development of ESCA and uncover new prognostic biomarkers based on microbial genes. In addition, this study provides a framework for the analysis of other human malignancies whose development may be driven by pathogens.
An iron-containing POM-based hybrid compound as a heterogeneous catalyst for one-step hydroxylation of benzene to phenol
Authors: Li Si-Man , Wang Ji-Lei , Zhou Jiu-Lin , Xiang Xin-Ying , Yu Ya-Ting , Chen Qun , Mei Hua , Xu Yan 
Published: December 2023

A POM-based hybrid compound {[FeII(pyim)2(CH5O)]2[HPMoV2MoVI9VIV3O42]}·H2O (Fe-PMo11V3) was synthesized via hydrothermal synthesis. Fe-PMo11V3 was used as a heterogeneous catalyst to achieve the selective conversion of benzene to phenol.
Self-Reported Stuttering Severity Is Accurate: Informing Methods for Large-Scale Data Collection in Stuttering
Authors: Horton Sarah , Jackson Victoria , Boyce Jessica , Franken Marie-Christine , Siemers Stephanie , John Miya St , Hearps Stephen , van Reyk Olivia , Braden Ruth , Parker Richard , Vogel Adam P. , Eising Else , Amor David J. , Irvine Janelle , Fisher Simon E. , Martin Nicholas G. , Reilly Sheena , Bahlo Melanie , Scheffer Ingrid , Morgan Angela 
Published: December 2023

Purpose:
To our knowledge, there are no data examining the agreement between self-reported and clinician-rated stuttering severity. In the era of big data, self-reported ratings have great potential utility for large-scale data collection, where cost and time preclude in-depth assessment by a clinician. Equally, there is increasing emphasis on the need to recognize an individual's experience of their own condition. Here, we examined the agreement between self-reported stuttering severity compared to clinician ratings during a speech assessment. As a secondary objective, we determined whether self-reported stuttering severity correlated with an individual's subjective impact of stuttering.

Method:
Speech-language pathologists conducted face-to-face speech assessments with 195 participants (137 males) aged 5–84 years, recruited from a cohort of people with self-reported stuttering. Stuttering severity was rated on a 10-point scale by the participant and by two speech-language pathologists. Participants also completed the Overall Assessment of the Subjective Experience of Stuttering (OASES). Clinician and participant ratings were compared. The association between stuttering severity and the OASES scores was examined.

Results:
There was a strong positive correlation between speech-language pathologist and participant-reported ratings of stuttering severity. Participant-reported stuttering severity correlated weakly with the four OASES domains and with the OASES overall impact score.

Conclusions:
Participants were able to accurately rate their stuttering severity during a speech assessment using a simple one-item question. This finding indicates that self-report stuttering severity is a suitable method for large-scale data collection. Findings also support the collection of self-report subjective experience data using questionnaires, such as the OASES, which add vital information about the participants' experience of stuttering that is not captured by overt speech severity ratings alone.
Robust stabilization of interval fractional‐order plants with an interval time delay by fractional‐order proportional integral derivative controllers
Authors: Ghorbani Majid , Tepljakov Aleksei , Petlenkov Eduard 
Published: December 2023

AbstractThis paper concentrates on presenting a reliable procedure to compute the stabilizing region of fractional‐order proportional integral derivative (FOPID) controllers for interval fractional‐order plants having an interval time delay. An interval fractional‐order plant is defined as a fractional‐order transfer function whose denominator and numerator coefficients are all uncertain and lie in specified intervals. Also, an interval time delay points to a delay term whose value varies in a specific interval. The D‐decomposition technique and the value set concept are employed to determine the stabilizing region of FOPID controllers. In this study, first, a theorem is presented to compute the boundary of the value sets of systems having interval time day. Then, a lemma is provided for robust stability analysis of the given closed‐loop control system. For a convenient use of the paper results, an algorithm is proposed to solve the problem of robustly stabilizing interval fractional‐order plants with an interval time delay using FOPID controllers. Finally, four examples are provided to illustrate the proposed procedure.
Analysis of voltage control using V2G technology to support low voltage distribution networks
Authors: Mattos Marina Martins , Archetti João Antônio G. , Bitencourt Leonardo de A. , Wallberg Alexander , Castellucci Valeria , Dias Bruno Henriques , de Oliveira Janaína G. 
Published: December 2023

AbstractThe decarbonization of the power generation and transport sector encourage the analysis of connection of distributed energy resources (DER), such as electric vehicles (EVs), to the electrical system, as well as the evaluation of their impact on smart cities. A better understanding of the negative impacts on the power systems will lead to propose mitigation measures and eventually revolutionize the way distributed generation works. This paper aims at modelling and evaluating the impact of EVs on a real distribution network. The energy system chosen operates at 60 Hz, 34.5 kV (medium voltage) and 0.208 kV (low voltage) and it is simulated using PSCAD/EMTDC. To reproduce realistic user consumption profiles, dynamic load profiles based on EV owners behaviour have been simulated. The vehicle‐to‐grid (V2G) technology is modelled to mitigate the impacts of high penetration of EVs by supporting the network from undervoltage. The results show the importance of active management in modern power systems, especially considering the increase in DER penetration expected for the coming years. This work shows the benefits of implementing V2G technology while highlighting the challenges involved in a real case.
Research progress in insulating and thermal conductivity of fluorinated graphene and its polyimide composites
Authors: Wang Xin , Liu Shuyan , Han Haoyu , Liu Xiangyang , Wang Xu 
Published: December 2023

AbstractThe demand for innovative thermal management materials with superior thermal conductivity and electrical insulating properties has significantly increased with the development of portable and flexible electronic gadgets. Fluorinated graphene (FG) has recently attracted the attention of the scientific community because of its exceptional thermal conductivity and electrical insulating qualities. This work aims to provide a detailed analysis of the structure‐property relationships inherent in FG, including both chemical and physical properties, and to explain the FG manufacturing process. Special attention should be paid to a thorough analysis of the thermodynamic conduction mechanism exhibited by FG, including the effects of corrugation size, fluorine coverage, and fluorine atom distribution on its thermal conductivity. The essay also examines in‐depth the most current and cutting‐edge developments addressing the utilisation of FG as a functional filler in composite‐modified polyimide (PI) materials. Furthermore, it has been noted as a crucial component in answering the needs for possible applications by maximising thermal conductivity and mechanical qualities in FG/PI composites through particular FG structural engineering and increased FG‐PI interaction. As a result, these elements serve as the main focus of ongoing research projects, highlighting important directions for development and investigation.
The cosmological analysis of X-ray cluster surveys
Authors: Cerardi N. , Pierre M. , Valageas P. , Garrel C. , Pacaud F. 
Published: December 2023

Context. Cosmological studies have now entered Stage IV according to the Dark Energy Task Force (DETF) prescription. New missions (Euclid, Rubin Observatory, SRG/eROSITA) will cover very large fractions of the sky with unprecedented depth. These are expected to provide the required ultimate accuracy in the dark energy (DE) equation of state (EoS), which is required for the elucidation of the origin of the acceleration of cosmic expansion. However, none of these projects have the power to systematically unveil the galaxy cluster population in the 1 < z < 2 range. There therefore remains the need for an Athena-like mission to run independent cosmological investigations and scrutinise the consistency between the results from the 0 < z < 1 and 1 < z < 2 epochs.
Aims. We study the constraints on the DE EoS and on primordial non-gaussanities for typical X-ray cluster surveys executed by a generic Athena-like Wide Field Imager. We focus on the impact of cluster number counts in the 1 < z < 2 range.
Methods. We consider two survey designs: 50 deg2 at 80 ks (survey A) and 200 deg2 at 20 ks (survey B). We analytically derive cluster number counts and predict the cosmological potential of the corresponding samples, A and B, by means of a Fisher analysis. We adopt an approach that forward models the observed properties of the cluster population in the redshift–count rate–hardness ratio parameter space.
Results. The achieved depth allows us to unveil the halo mass function down to the group scale out to z = 2. We predict the detection of thousands of clusters down to a few 1013h−1 M⊙, in particular 940 and 1400 clusters for surveys A and B, respectively, at z > 1. Such samples will allow a detailed modelling of the evolution of cluster physics along with a standalone cosmological analysis. Our results suggest that survey B has the optimal design as it provides greater statistics. Remarkably, high-redshift clusters represent 15% or less of the full samples but contribute at a much higher level to the cosmological accuracy: by alleviating various degeneracies, these objects allow a significant reduction of the uncertainty on the cosmological parameters: Δwa is reduced by a factor of ∼2.3 and
Δ fNLloc
by a factor of ∼3.
Conclusions. Inventorying the deep high-z X-ray cluster population can play a crucial role in ensuring overall cosmological consistency. This will be the major aim of future new-generation Athena-like missions.
Bewegungsförderung durch Bewegungscoaches in der
Adipositas-Selbsthilfe – eine Pilotstudie
Authors: Joisten Christine , Schmidt Lisa 
Published: December 2023

ZusammenfassungDie Rolle der körperlichen Aktivität in der Prävention
und vor allem in der Therapie der Adipositas ist heutzutage unbestritten.
Allerdings sind die Möglichkeiten auf vielen Ebenen begrenzt: u.a.
aufgrund persönlicher Barrieren und Hindernisse, wie
Schamgefühl, erfahrene Stigmatisierung, aber auch aufgrund mangelnder
adäquater Angebote. Eine niederschwellige Möglichkeit stellt die
Qualifizierung von Selbsthilfegruppen (SHG)-Leitungen zu Bewegungscoaches dar,
um durch aktive Pausen und Übungen im Rahmen der Selbsthilfegruppen
Teilnehmende zu mehr Bewegung zu motivieren. Zu diesem Zweck wurden in dieser
Pilotuntersuchung 14 SHG-Leitungen qualifiziert und die Machbarkeit und
Umsetzung im mixed-methods Design geprüft. Auf Basis von 11
Fragebögen von 13 Teilnehmenden zeigte sich, dass die Inhalte insgesamt
sehr positiv aufgenommen wurden, vor allem die bewegungspraktischen Einheiten.
Kombiniert mit dem Lerneffekt, dass auch kleine Bewegungseinheiten
förderlich für die Gesundheit sind, setzten anschließend
73% durchschnittlich 1,4±0,5 Bewegungseinheiten mit
12,9±7,3 SHG-Teilnehmenden während der Gruppentreffen um. 7 von
11 beschrieben eine insgesamt positive Resonanz ihrer Gruppen trotz
früherer Negativ-Erfahrungen. Eine SHG-Leitung beurteilte die
Durchführung als negativ, 4 machten keine Angabe. Unter
Berücksichtigung des Pilotcharakters zeigt sich hier ein erfolgreicher
niederschwelliger Ansatz der Bewegungsförderung; inwiefern
tatsächlich klinisch relevante Effekte bei SHG-Teilnehmenden
nachgewiesen werden können, muss in weiteren randomisiert-kontrollierten
Studien nun geprüft werden.
Ein Gewichtsreduktionskurs mit dem Schwerpunkt der Stärkung
von „Coping“ Strategien für die low carb
Ernährung ist einfach und erfolgreich
Authors: Lilienfeld-Toal Anna. v. , Tews Dietrich , Lilienfeld-Toal Hermann v. 
Published: December 2023

ZusammenfassungEin Weg zur Reduzierung des Körpergewichts besteht in der Reduktion der
Aufnahme von Kohlenhydraten mit der Nahrung, sodass geringere postprandiale
Anstiege von Blutglukose und Insulin auftreten. Allerdings führt die
Senkung der Blutglukose zu starken Impulsen in der Regulation der
Nahrungsaufnahme. So werden verschiedene Essimpulse bei Menschen mit
Übergewicht ausgelöst, die Kohlenhydrate in der Nahrung
vermeiden. Wir stellten diese Impulse zusammen und entwickelten ein
systematisches Vorgehen, um ihnen zu begegnen. Hiermit bildeten wir ein
Curriculum für einen 1-Jahres-Kurs mit Übergewichtigen, die sich
eine Gewichtsreduktion vornahmen. Die Gruppensitzungen wurden von einer
geschulten Person geleitet. Im Curriculum war zusätzlich ein Austausch
über die Erlebnisse während der Kohlenhydrat-Reduktion
enthalten, sowie die Vermittlung von Wissen über die Pathomechanismen
der Gewichtsentwicklung. Weitere Anforderungen an die Teilnehmer wurden nicht
gestellt. Am Ende des einjährigen Kurses reduzierten 18 Teilnehmer aus
mehreren Gruppen ihr Gewicht im Mittel um 8,6% vom Ausgangsgewicht.
Parameter des Glukosestoffwechsels besserten sich ebenso wie psychologische
Indikatoren für Essimpulse. Wir nehmen an, dass ein solcher Kurs in
Gruppen, der sich auf die psychologischen Gefahren konzentriert, die mit einem
Vermeiden von Kohlenhydraten in der Nahrung verbunden sind, ein einfach
anwendbarer Weg gegen das Problem des Übergewichtes in jeder
spezialisierten Einrichtung ist.
Magenballonimplantation – eine Bestandsaufnahme unter
Berücksichtigung eigener Erfahrungen
Authors: Keßler Rebecca , Glitsch Anne , Hübner Björn , Gärtner Simone , Steveling Antje , Patrzyk Maciej , Keßler Wolfram 
Published: December 2023

ZusammenfassungDie Magenballontherapie wird aktuell konträr diskutiert. Dennoch stellt
dieses Verfahren aus unserer Sicht ein bewährtes und
verhältnismäßig sicheres Hilfsmittel zur kontrollierten
Gewichtsreduktion dar. Die hier nachgewiesene Reduktion aller
Körperfettkompartimente und die signifikante Reduktion des Lebervolumens
ist ein Ergebnis, welches weitere Forschungsansätze eröffnet und
in der Folge ggf. auch eine (positive) Neubewertung des Magenballons im Rahmen
der Adipositas-Therapie erfordert. So ist über das Verhalten von
Gasblasen in Magenballons bisher wenig bekannt. Bei der zukünftigen
Forschung sollte jedoch sehr viel Wert auf eine korrekte Indikationsstellung
(Ziel der Magenballontherapie) und Durchführung der Implantation gelegt
werden.
Through-the-scope clip retention rates and performance in a porcine model
Authors: AbiMansour Jad , Kamba Shunsuke , Wong Kee Song Louis-Michel , Rajan Elizabeth 
Published: December 2023

Abstract
Background and study aims Limited comparative data exist to guide optimal through-the-scope (TTS) clip selection. The aim of this study was to compare the efficacy, retention, and safety of three industry-leading TTS clips on tissue that mimics common clinical scenarios.
Methods A survival study involving six domestic pigs was undertaken. Three commonly used clip models were selected: Assurance (STERIS, Mentor, Ohio, United States), Resolution (Boston Scientific, Boston, Massachusetts, United States), and SureClip (Micro-Tech, Ann Arbor, Michigan, United States). To mimic clinical practice, the following scenarios were assessed: (1) normal mucosa; (2) cold snare resection; and (3) hot mucosal resection simulating fibrotic ulcers. Deployment of clips was randomized to target sites. Repeat endoscopy was performed 2 weeks following placement. Endoscopists rated the ease of use of clip placement on a Likert scale of 1 to 5.
Results Fifty-four clips (18 Assurance, 18 Resolution, and 18 SureClip) were placed in six pigs. Mucosal healing was noted at all sites on follow up. Overall retention was nine of 18 (50.0%) SureClip, 10 of 18 (55.6%) Assurance, and 13 of 18 (72.2%) Resolution (P=0.369). There was no difference in clip retention on normal and cold snare resection sites; however, clip retention was significantly higher for Resolution clips on fibrotic ulcers (50.0% versus 0% for Assurance and 0% SureClip, P=0.03). No adverse events were reported. Ease of use was equivalent across all models.
Conclusions All clips were equivalent in efficacy and safety with successful clip deployment and mucosal healing. Overall retention rate was low for fibrotic tissue, with an improved retention rate observed with Resolution clips.
Efficacy of Cranial Orthosis for Plagiocephaly Based on 2D and 3D Evaluation
Authors: Kajita Hiroki , Tanaka Ichiro , Komuro Hiroaki , Nishimaki Shigeru , Kusakawa Isao , Sakamoto Koichiro 
Published: December 2023

Abstract
Background With the advent of cranial orthoses as therapeutic medical devices for the treatment of severe positional head deformities in Japan, an increasing number of patients are being treated with them. However, assessing the effectiveness of a treatment is often difficult due to the use of different metrics. This study aimed to evaluate the effectiveness of cranial orthoses for deformational plagiocephaly using two- (2D) and three-dimensional (3D) evaluation metrics.
Methods We conducted a retrospective study of infant patients with deformational plagiocephaly who underwent cranial orthosis treatment. We evaluated the severity of deformational plagiocephaly using cranial asymmetry (CA) and the cranial vault asymmetry index (CVAI) as 2D metrics, and anterior and posterior symmetry ratios as 3D metrics. The patients were divided into 24 subgroups based on the initial severity of each outcome and their age at the start of treatment. We analyzed the changes in outcomes and correlations within improvements across the age and severity categories.
Results Overall, 1,038 infants were included in this study. The mean CA, CVAI, and anterior and posterior symmetry ratios improved significantly after cranial orthosis treatment. The improvement in each score was greater in patients with more severe initial deformities and in those who underwent treatment at a younger age.
Conclusion Cranial orthosis treatment was effective in correcting deformational plagiocephaly in infants, as demonstrated by improvements in both 2D and 3D metrics. Patients with more severe initial deformities and those who underwent treatment at a younger age showed greater improvement.
Organocatalytic Approach to the Enantioselective Total Synthesis of (+)-Serinolamides A and B and (+)-Lacosamide
Authors: Waghmode Suresh B. , Jadhao Amardeep R. 
Published: December 2023

AbstractA short and highly efficient enantioselective synthesis of (+)-serinolamide A, B and (+)-lacosamide from 3-methoxypropanal using l-proline-catalyzed α-amination, Grubbs metathesis, and acid-amine coupling as key steps is reported.