bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Early Growth Response Protein (EGR) Levels in Patients
with Fibromyalgia Syndrome: A Cross-Sectional Study
Authors: Tas Ayca , Agbektas Tugba , Karadag Ahmet , Aydin Süleyman , Hayta Emrullah , Silig Yavuz 
Published: November 2023

Background:
Fibromyalgia is a soft tissue rheumatism characterized by chronic and
widespread musculoskeletal pain at specific points in the body.

Objectives:
In this study, we aimed to investigate the relationship between Early Growth Response
(EGR1, EGR2, and EGR3) protein levels in patients with Fibromyalgia Syndrome (FMS)
and healthy controls.

Methods:
In our studies, 76 FMS patient group and 78 healthy control group who were newly diagnosed
with primary FMS according to the 2010 American College of Rheumatology criteria for
fibromyalgia in Sivas Cumhuriyet University Hospital, Physical Therapy, and Rehabilitation were
used. Venous blood samples were taken from both groups for the measurement of EGR1, EGR2,
and EGR3 protein plasma levels, and protein levels were determined using ELISA methods. Statistical
parametric test assumptions were compared using the Independent Student's t-test. In addition,
specificity, sensitivity, and AUC values were calculated with the ROC curve.

Results:
The relationship between plasma EGR1 protein levels of FMS patients and control
groups was statistically significant (p=0.001).

Conclusion:
EGR1 protein levels were found to be lower in the patient group diagnosed with
FMS compared to the control group. It has been suggested that EGR1 protein levels can be important
in the diagnosis of FMS disease.
STAM-binding Protein-like 1 Promotes Growth and Migration of
Colorectal Cancer by NF-κB Pathway
Authors: Zhou Xinghua , Cheng Yue , Kang Jian , Mao Gang 
Published: November 2023

Background:
STAM-binding protein-like 1 (STAMBPL1) functions as a deubiquitinase
to cleave Lys63 ubiquitin linkage, and is associated with cancer dissemination and progression.
The role of STAMBPL1 in colorectal cancer (CRC) remains unclear.

Methods:
STAMBPL1 expression was determined by western blot and qRT-PCR. Cell proliferation
was detected by colony formation and MTT assays, and apoptosis was assessed by flow cytometry.
The metastasis was evaluated by transwell and wound healing assays. An animal xenograft
experiment was used to investigate the effect of STAMBPL1 on tumor growth.

Results:
The expression of STAMBPL1 was elevated in CRC cells. Knockdown of STAMBPL1
reduced cell viability of CRC and suppressed the proliferation, invasion, and migration. Apoptosis
of CRC was induced by silence of STAMBPL1. Tumor growth of CRC was also suppressed by
the silence of STAMBPL1. Knockdown of STAMBPL1 increased IκB and decreased phosphorylation
of IκB to reduce p65 phosphorylation.

Conclusion:
Knockdown of STAMBPL1 inhibited cell growth and metastasis of CRC through inactivation
of the NF-κB pathway.
Study of Structural Elucidation, Degradation Kinetics and Antimicrobial
Analysis of Copper (II) Sesame-Soap Complexes with Urea and Thiourea
Ligand in Non-aqueous Solvents
Authors: Meena Asha 
Published: November 2023

Abstract:
Surfactants have great importance in biological and drug industries and the complexes of
metallic soaps with various ligands are used in approximately every region of national economy.
Therefore, our keen interest to study of degradation kinetics and biological importance of Cu (II) surfactants
in non-aqueous and non-polar solvent benzene. Present research work has been initiated with
synthesis, systematic study of structural elucidation, thermal degradation, kinetics and biocidal activities
of copper (II) sesame-soap complexes with macrocyclic nitrogen and sulphur containing donar
ligands like urea and thiourea. The thermal degradation of copper (II) sesame-soap complexes were
carried out for analysis of degradation kinetics and estimation of kinetic and thermodynamic parameters
using different methods at heating rate 10oC min-1. Copper (II) sesame-soap complexes of such
ligands have also been analysed against Staphylococus aureus. This research work consolidates the
synthesis of copper (II) sesame soap-urea and thiourea complexes by conventional methods and the
structure of these complexes were assigned according to elemental analysis and molecular weight determinations.
IR, NMR and ESR spectral studies have also been done to understand structural aspects.
The anti-microbial activities of copper (II) sesame-soap urea and thiourea complexes have been
evaluated by testing against Staphylococus aureus. The present research work includes information of
thermal analysis using TGA technique to find out their kinetic and thermodynamic parameters by using
diverse equations such as Coats-Redfern equation, Horowitz-Metzger equation, Broido equation,
Piloyan–Novikova equation. Moreover, the results obtained from anti-microbial screening have been
used to analyze the anti-microbial activities of copper (II) sesame-soap urea and thiourea complexes
against gram-positive bacteria Staphylococus aureus. These results show that complexes of copper
ion co-ordinated with different nitrogen, oxygen and sulphur containing ligands, are very important in
the field of pharmaceutical chemistry due to its significant role in the inhibition activity. The study of
these complexes concludes that the synthesized complexes were found to possess appreciable bactericidal
properties at different concentrations because chelation increases the anti-microbial potency.
Microencapsulation of Doxorubicin Using Chitosan
Authors: Puertas José , López Arianne , Cazorla Francisco González , Labrador Manuel Giménez , Repetto Baubin Mattias Adrian , Arias Manuel José Lis 
Published: November 2023

Introduction:
For some medical treatments associated with cancer, the invasion of
organs is required, which must be done in a totally controlled way to obtain the expected results
in the treatment. Today, most medical treatments make use of invasive therapies to combat the
affected cancer tissues. Acting in this way also destroys those tissues not affected by the
generation of tumor centers that confront the cancer tumor center to be treated.

Methods:
To ensure the objective of the treatment, doses of the drug to be administered in a little controlled and free via are used that are ultimately ineffective due to the high degradation of the active compound due to its non-existent stabilization and protection after its passage through the body and consequently possible episodes of phagocytization, responsible for the reticuloendothe-lial system. It is well known the side effects that one of the most promising anti-cancer molecules, doxorubicin, shows. This is a problem for its use, and one of the possibilities to avoid these desired behaviors, microencapsulation could be a possible approach.

Results:
Microencapsulation of drugs allows the design of micro-level structures capable of con-taining the active agent with sufficient protection and stabilization to be able to reach the target site with the highest possible concentration of drug to be able to be gradually released in its entirety and produce the desired effect in the therapy in a controlled way according to a previous-ly studied kinetic profile, which will allow a type of treatment in which the therapy will be non-invasive due to the high degree of targeting selectivity that the microcapsule allows.

Conclusion:
The use of the amine groups present in the chitosan polymer's structure to increase or modify the molecular interactions with doxorubicin is a very interesting aspect that will be treated here. These interactions help to make possible the control and protection of the active principle, as it is shown in the quantification of the drug-delivery behavior of the system made.
Extracción transuretral de un urolito en una yegua mediante litotricia manual y una bolsa de recuperación laparoscópica
Authors: Arévalo Naranjo Mónica Alexandra , González Carballo José Rafael , Giraldo Andrés , Salcedo Jiménez Ramés 
Published: November 2023

Descripción del caso. Una yegua hannoveriana de 25 años fue remitida a la Clínica de Grandes Especies del Colegio Veterinario de Ontario de la Universidad de Guelph para la remoción de un urolito. El animal provenía de Guelph, Ontario, provincia de Canadá que se caracteriza por tener un clima templado y nublado.
Hallazgos clínicos. Antecedentes de hematuria y diagnóstico previo de urolitiasis cística.
Pruebas de laboratorio. Ultrasonografía y cistoscopia. En el ultrasonido transrectal se encontró una estructura hiperecoica de 10 cm en la vejiga de la paciente congruente con el diagnóstico previo de urolito vesical. Posteriormente se realizó una cistoscopia clasificando al urolito como tipo i.
Tratamiento y evolución. La remoción del urolito se realizó a través de una técnica transuretral con el uso de una bolsa de recuperación laparoscópica. El procedimiento se llevó a cabo con la paciente de pie usando sedación y un bloqueo epidural caudal. El área perineal se preparó asépticamente y mediante endoscopia estéril, se ingresó a la uretra. La bolsa de recuperación laparoscópica fue introducida pasando al lado del endoscopio, y una vez dentro de la vejiga, fue abierta para manipular el urolito. Debido al tamaño del urolito se utilizó un osteótomo y un martillo para fragmentarlo y extraerlo. No se reportaron complicaciones a corto o largo plazo.
Relevancia clínica. La extracción de urolitos mediante una bolsa de recuperación laparoscópica constituye una alternativa mínimamente invasiva, eficiente y con tiempos de recuperación mínimos inclusive si los urolitos son de gran tamaño.
INTERLACING MAXIMS AS REFLECTED IN THE ENGLISH STUDENTS’ VERBAL COMMUNICATION
Authors: Rachmawati Rachmawati , Al Arif Tubagus Zam Zam 
Published: November 2023

The current research serves to portray the interlacing maxims which are reflected in the English Department students’ verbal communication and to depict the politeness which is manifested in the realization of those maxims holistically on the basis of the existing context of speech. The research is designed in the descriptive- qualitative-interpretative by means of the interactive model. This model comprises three research lines, namely: data reduction, data display, and data conclusion/ verification. The data for the present research were gathered repeatedly up to they are exhausted. In terms of data reduction, it is carried out by decreasing the unnecessary utterances or by maintaining the utterances that confirm the graciousness. The utterances that confirm the maxims and graciousness are displayed for having the analysis. The analysis are verified several times up to the researchers come at the equal conclusion. Accordingly, the research engages a group (class) of students as the research participants and it reveals the sequence of maxims, i.e., (1) the Tact maxim, (2) the Generosity maxim, (3) the Approbation maxim (4) the Modesty maxim, and (5) the Agreement maxim conveyed in the diverse contexts by the English Department students at Faculty of Teacher Training and Education, Jambi University.
STUDENTS’ PERSPECTIVE OF ENGLISH-INDONESIA TRANSLATION ON TWITTER WEB PAGES
Authors: Lindri Rima Rahmadhika 
Published: November 2023

ABSTRACT
This qualitative research was conducted by describing An Analysis of English-Indonesia Translation Quality on Twitter Web Pages. There was one question addressed. The question described how the quality of the Indonesian version of Twitter Web pages is. Method and the design applied in this research were descriptive qualitative. Population of this research is ten students of the seventh semester who have completed the translation practice course. To get the data for this research, the researcher has some steps; the first step to collect the data, the researcher gives the questionnaires to the participant. Then, the researcher sees how the results of the questionnaires. After that, the researcher can interview the participants according to the results of the questionnaires. It means there are two types of data collecting procedure: questionnaires and interviews. The results showed ten respondents admit that participants had good perceptions by selecting "Acceptable." The participants think the researcher's translation from Twitter gave in the questionnaire accurate, accepted, and readable. The last for acceptability, acceptability relates to the naturalness of the translation product to target readers. Participants agreed that this translation was acceptable, because they could read the nature of the translation. Implications of this research to investigate the translation quality based on students who have followed the course.
Keyword: Translation,Twitter, Perspective
ENGLISH STUDENTS’ DIFFICULTIES IN COMPLETING READING TOEFL SECTION AT EIGHT SEMESTER AT UNIVERSITAS JAMBI
Authors: Isma Gustin Ratu Gairah 
Published: November 2023

This study aims to determine whether TOEFL reading skills are more difficult for English study program of students at Universitas Jambi, based on TOEFL reading skills given to students in the eighth semester at Universitas Jambi , and whether TOEFL reading skills are difficult for English Study Program students at Universitas Jambi. The data of this study were collected using mixed method, quantitative design with a survey study and qualitative design with a descriptive study approach involved 23 participants. The participants in this study were eight semester students at English study program in Universitas Jambi. This study used the data collection TOEFL reading test,TOEFL reading score, and interview. TOEFL reading test was used for describing students’ difficulty. Interview was used for investigating whether the students’ experience the difficulties or not. The TOEFL reading test and an interview were main instruments in this study. TOEFL reading score was a supplementary instrument that can assist the researcher in selecting the students who needed a low grade to be questioned. Firstly, the students’ experience the difficulty in reading section of TOEFL test such as lack of accuracy in reading, availability of time during test, and lack of vocabulary. Secondly, the result of this study showed that the ordering of difficulty items in TOEFL reading skills encompasses responding of transition questions (0.9), finding topic/main idea (0.21), finding specific information (0.21), and finding stated details (0.26).
The Influence of Subtropical Mode Water in Nutrients in the South Atlantic
Authors: Birocchi Paula , Bernardo Piero S , Sato Olga T 
Published: November 2023

The South Atlantic subtropical mode water (STMW) is characterized by
a volume of water confined between the seasonal and
permanent thermoclines. It is formed during the months of winter to
early spring, July to October, near the Brazil-Malvinas Confluence
region and the Brazil Current recirculation gyre. The STMW presents a
homogeneous temperature (T) and salinity distribution in the
horizontal and vertical, on average reaching up to 170 m of layer
thickness. We investigate the impact of STMW in the nutrient’s
distribution and the nutricline depth in the western South Atlantic.
Three data sets were used to identify the mode water and determine
nutrients concentration:i) My Ocean biogeochemical model reanalysis; ii)
World Ocean Atlas 2013 (WOA13) monthly climatology; and iii) the In Situ
Analysis System (ISAS) data. Based on WOA13, during the summer (January,
February and March) the STMW is found at subsurface from 100 m to 225 m
deep; it has a mean layer thickness of 112 ± 5.0 m, reaching a maximum
of 145 m. During the winter, the maximum layer thickness is 250 m while
the mean is 155 ± 20.3 m. In the summer, STMW is in subsurface from 100
m to 225 m deep. As expected, the formation of mode water occured mostly
in the winter to mid-spring. Using the model and ISAS data, we found a
correlation between a deepening of the surface layer of minimum nitrate
concentration and the mode water formation period (from June to
October) in vertical profiles. From 2002 to 2012, greater nutrients
concentration were found during the STMW formation period, from surface
to 200 m depth, than in other periods with STMW absence. We also found a
peak chlorophyll-a concentration during STMW formation period,
suggesting that STMW presence in the southwest South Atlantic is
important for biological processes in the upper ocean.
Video Pembelajaran Berbasis Microlearning pada Muatan IPAS
Authors: Aritonang Rido , Desak Putu Parmiti  , I Komang Sudarma  
Published: November 2023

Rendahnya hasil belajar siswa disebabkan oleh minimnya media pembelajaran khususnya dalam muatan IPAS, yang menyebabkan siswa sulit untuk memahami materi. Tujuan penelitian ini yaitu mengembangkan video pembelajaran berbasis microlearning. Jenis penelitian ini yaitu penelitian pengembangan dengan menggunakan prosedur model ADDIE. Subek uji coba penelitian ini yaitu 1 orang ahli isi pembelajaran, 1 orang ahli desain pembelajaran, 1 orang ahli media pembelajaran, 3 orang uji coba perorangan, 6 orang uji coba kelompok kecil, dan 30 orang uji coba lapangan. Teknik yang digunakan untuk mengumpulkan data yaitu observasi, wawancara, pencatatan dokumen dan kuesioner. Instrument yang digunakan dalam mengumpulkan data yaitu kuesioner. Teknik yang digunakan untuk menganalisis data yaitu analisis deskriptif kualitatif dan analisis deskriptif kuantitatif. Hasil penelitian yaitu hasil review ahli isi pembelajaran memperoleh skor 90% (berkualifikasi sangat baik), hasil review ahli desain pembelajaran memperoleh skor 93,3% (berkualifikasi baik), hasil review ahli media pembelajaran memperoleh skor 94% (berkualifikasi sangat baik), hasil uji coba perorangan memperoleh persentase skor 96,6% (berkualifikasi sangat baik), hasil uji kelompok kecil memperoleh persentase skor 95,5% (berkualifikasi sangat baik), dan hasil uji lapangan memperoleh persentase skor 94,6% Jadi media video pembelajaran berbasis microlearning pada muatan IPAS layak untuk digunakan. Implikasi penelitian ini yaitu media yang dikembangkan dapat digunakan oleh guru dalam meningkatkan pemahaman siswa pada muatan IPAS.
A recepção no exterior: a história das traduções desde os anos de 1950
Authors: Gotlib Nádia Battella 
Published: November 2023

Uma das maiores especialistas na obra de Clarice Lispector, a professora e pesquisadora Nádia Battela Gotlib publicou diversos artigos e livros sobre a autora. Destacamos a obra Clarice, uma vida que se conta, leitura de vida e obra da escritora, e o livro Clarice Fotobiografia, uma fotobiografia de Clarice Lispector, narrativa visual da história de vida e obra de Clarice Lispector, com 800 imagens, na sua grande maioria, inéditas.
Nos 6 blocos que compõem essa entrevista, Nádia apresenta um panorama da vida e da obra de Clarice Lispector, destacando pontos importantes sobre a recepção da obra clariciana no Brasil e no exterior. São apontadas ainda questões relevantes sobre as traduções das obras de Clarice e as adaptações para outras mídias como cinema e teatro.
Edição: Ana Paula Rodrigues da Silva, Thiago Fonseca (TV-PUC)Música: PIPA estúdio
Pengendalian Motor Brushless Direct current Dengan Frekuensi Tinggi Pulse Width Modulation Dengan Metode Back-Electromotive Force Menggunakan Microcontroller
Authors: Harahap Charles Ronald , Komalasari Endah 
Published: November 2023

Abstract — Research on speed control of electric motors has developed, especially the BLDC motor. In previous research, the pulse width modulation (PWM) has been controlled using the voltage and duty cycle to control the motor speed. The PWM method is a method that is widely used in controlling BLDC motor speed. This research will discuss controlling the speed of the BLDC motor using the PWM modulation method with the switching frequency of 20 KHz and the frequency generated from Arduino reaches 300 Hz. In this study, two tests will be carried out, namely no load and loaded tests. From the two tests carried out, data is obtained in the form of the speed, power, and torque of the motor based on changes in the frequency. The no-load test produces a maximum speed of 14,328 rpm, a power of 71,2 watts, and a torque of 0,047 Nm. During the load test, the maximum speed is 12,060 rpm, power is 79,3 watts, and torque is 0.062 Nm.
Keywords— BLDC motor, pulse width modulation, frequency variable, Arduino Mega 2560
Penerapan Bimbingan Kelompok Dengan Teknik Role Playing Untuk Meningkatkan Jiwa Kepemimpinan Siswa Kelas X SMK N 1 Kalinyamatan Jepara
Authors: Paramita Suci Paramita , Kiswantoro Arista , Lestari Indah 
Published: November 2023

Organizational operations need maximum participation from all members. Therefore, the success of an organization is not just dependent on the facilities at its disposal, but also on the quality of its leadership. The development of a culture of leadership has to begin in the classroom, particularly at the high school level. The low leadership spirit for students of high school students will be overcome through various kinds of guidance applications, one of which is group guidance.
Nutritional Level and Quality – Condition and Component of Animal Welfare
Authors: Sonea Cosmin , Gurau Maria Rodica , Chetroiu Rodica , Pituru Maria-Teodora 
Published: November 2023

Abstract
This paperwork highlights the role that plays the animal nutrition, in terms of level and quality, in relation to interdependence with other animal welfare criteria. It is necessary to apply nutritional strategies, taking into account the optimization of feeding conditions and nutritional intakes, in order to meet the objectives of animal welfare, which must take into account both health and environmental conditions, their maintenance and their service. In this way, the administration of food and the provision of all the necessary nutrients, depending on the species, the category of production, the physiological state must be applied in such a way that each animal has the freedom to express its normal behavior under conditions of well-being.
Use of Muscaturi Rkatsiteli in Winemaking
Authors: Kitiashvili Saba , Gotsiridze Olani 
Published: November 2023

Abstract
Georgia has 525 autochthonous grape varieties, despite this, in the 20th century, the process of selection of Georgian grape varieties was actively going on, one of the results of which is Muskaturi Rkatsiteli.