bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role and Therapeutic Potential of the TFAP2C-EIF5A Signaling Pathway in Bladder Cancer Development
Authors: Lei Mingde , Zhang Shicheng , Han Qi , Liu Liwei 
Published: October 2023

Abstract
Bladder cancer is a common malignant tumor, and the molecular mechanisms underlying its onset and progression are unclear. In this study, we analyzed the cellular heterogeneity and subpopulations of bladder cancer patients using single-cell sequencing data, and found that the expression levels of the transcription factor TFAP2C and the translation initiation factor EIF5A were significantly elevated in bladder cancer tissues and positively correlated with cancer mortality. Further in vitro experiments verified that TFAP2C could up-regulate the expression of EIF5A, thereby promoting the proliferation, migration and invasion ability of bladder cancer cells. In addition, we found that inhibition or activation of EIF5A could affect the function of TFAP2C. These results reveal the important role of the TFAP2C-EIF5A signaling pathway in bladder cancer development and provide new targets and strategies for the future treatment of bladder cancer.
The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages
Authors: Brouwer Hugo , Porbahaie Mojtaba , Boeren Sjef , Busch Mathias , Bouwmeester Hans 
Published: October 2023

Abstract
Background: Micro- and nanoplastics (MNPs) represent one of the most widespread environmental pollutants of the 21st century to which all humans are orally exposed. Upon ingestion, MNPs pass harsh biochemical conditions within the gastrointestinal tract, causing a unique protein corona on the MNP surface. Little is known about the digestion-associated protein corona and its impact on the cellular uptake of MNPs. Here, we systematically studied the influence of gastrointestinal digestion on the cellular uptake of neutral and charged polystyrene MNPs using THP-1-derived macrophages.
Results: The protein corona composition was quantified using LC‒MS-MS-based proteomics, and the cellular uptake of MNPs was determined using flow cytometry and confocal microscopy. Gastrointestinal digestion resulted in a distinct protein corona on MNPs that was retained in serum-containing cell culture medium. Digestion increased the uptake of uncharged MNPs below 500 nm by 4.0- to 6.1-fold but did not affect the uptake of larger sized or charged MNPs. Forty proteins showed a good correlation between protein abundance and MNP uptake, including coagulation factors, apolipoproteins and vitronectin.
Conclusion: This study provides quantitative data on the presence of gastrointestinal proteins on MNPs and relates this to cellular uptake, underpinning the need to include the protein corona in hazard assessment of MNPs.
Influence of strong electric field on the properties in semiconductor quantum dot
Authors: NOUPEYI S. D. , Nguepnang J.V. , Ekengoue  , Kenfack A.J. 
Published: October 2023

Abstract
Polarons are quasiparticles that result from a strong coupling regime between electron or a hole and ions in nanomaterials. Polarons manifest themselves in many different ways under the influence of external electric and (or) magnetic fields. This paper investigates the influence of strong electric field on polaron properties in semiconductor quantum dot (SCQD). We used the modified Lee Low Pines Huybrecht method to derive fundamental and first state energy of polaron. The superposition of these two states energies which form a quantum bit considered as a two level system (TLS) allowed us to evaluate the probability density, capacitance and conductance of the polaron under the Drude model. Our results indicate that the electric field possesses pronounced effects on the properties of polaron in SCQD. Some of these effects include but are not limited to: (i) the variation of the probability density according to the x and y planar coordinates; (2i) the periodical modification of the probability density with electric field frequency and its dependence on longitudinal optical (LO) phonon-coupling strength constant; (3i) the observation of both positive and negative values of the energy of the system, indicating the formation of free and couple polaronic entities in the system. In particular, we found that the ground state energy of the polaron is predominant in Galium Arsenide (GaAs) SCQD. It comes that, the investigation of strong polaron-electric field (laser radiation) is quite indicated in the case of Galium Arsenide (GaAs).
Knowledge, Attitudes, and Practice of Egyptian Medical Students Towards Healthcare Workers’ Recommended Vaccines: A Nationwide Cross-Sectional Survey
Authors: Shawqi Mohamed Mohamed , El-Said Yara Mohamed , Behery Mostafa Behery , Abdelaziz Ali , Ibrahem Esraa Shawky , ElBoraie Aly , Khattab Mohamed Ayman , Ghattas Ahmed S. , Naeem Ahmed , Madany Maysa , Elboraay Toka , Naguib Mostafa Mahmoud , Allam Abdallah R. , Allam Ahmed Hafez , Bahbah Ammar Ayman , Ewis Marwa Ibrahim , Elsayed Mostafa Ahmed , Sherief Leenah , KhallafAllah Mahmoud Tawfik , Gouda Mohamed Alaa , Aboshady Omar Ali 
Published: October 2023

Abstract
Background
Vaccination of healthcare workers (HCWs) is pivotal to decrease the incidence of contagious infections in hospital settings. Herein, we assessed the knowledge, attitude, and practice regarding HCWs’ recommended vaccines among medical students and interns in Egypt.
Methods
A multicenter, cross-sectional study was conducted using a structured, pilot-tested, self-administered questionnaire among Egyptian medical students and interns. We invited 1332 participants to our survey using a systematic random sampling that included participants across nine medical schools in Egypt during the 2021–2022 academic year.
Result
Out of 1332 participants, 1141 completed our questionnaire with a response rate of 85.7%. Overall, 43% of our participants knew 2–3 HCWs recommended vaccines. Furthermore, 36.7% had received a booster dose of at least one of the HCWs’ recommended vaccines in the last 10 years with only 6.1% having received all recommended vaccines. Hepatitis B vaccine was the most widely known (71%) and received (66.7%). Interns were more likely to know, receive, and recommend HCWs’ recommended vaccines. The majority (> 90%) agreed that vaccination is beneficial and safe, with a median score of eight (interquartile range [IQR]: 2) out of ten concerning vaccine efficacy and eight (IQR: 1) for safety. However, the median score for hesitancy was five (IQR: 5). The most common influential and limiting factors for taking vaccines were scientific facts (60.1%) and fear of vaccine side effects (44.9%), respectively.
Conclusion
Although medical students in Egypt have good knowledge and attitudes toward vaccinations, there is a gap in their practices. Interventions are needed to improve the uptake of vaccinations among medical students in Egypt.
The generalized core-EP inverses involvoing projections in Banach *-Banach algebra
Authors: Chen Huanyin , Abdolyousefi Marjan Sheibani 
Published: October 2023

Abstract
In this paper, we introduce the notion of the generalized weighted core inverse in a Banach *-algebra. We characterize this new generalized inverse by using the generalized weighted core decomposition and present the representations by the generalized Drazin inverse. These extend the core-EP inverse and weighted (pseudo) core inverse for complex matrices and linear bounded operators to more general setting.
2020 Mathematics Subject Classification. 15A09, 16U90, 46H05.
Clinical and Radiographic Approach of (Nephroblastoma – Neuroblastoma) in children.
Authors: lahej Najeh , Aljarad Ali , Alhasheesh Mohammad , khattab Khalid 
Published: October 2023

Abstract

The study showed the prevalence and importance of both tumors in diagnosis and follow-up, as it was found that Wilms' tumor is the most common malignant solid abdominal tumor in children, and that neuroblastoma is the most common solid abdominal tumor in the upper abdomen in children and infants. Wilms' tumor has degrees of risk according to differentiation and spread. There is a laboratory test through which Wilms' tumor can be diagnosed (unlike nephroblastoma). Neuroblastoma compresses the kidney from the outside, while nephroblastoma distorts and damages the kidney from the inside (renal excretory system). The presence of a solid mass inside a kidney that causes internal torsion of the calyx collecting system is considered diagnostic. For Wilms' tumor, ultrasonography can help evaluate the venous extension of the tumor (inferior vena cava and renal veins)
Comparison of the Effect of Various Surface Treatments on the Microtensile Bond Strength of Lithium Disilicate Ceramic with Dentin- An In-vitro Study
Authors: Shrivastava Ankita , Sharma Sanjay Kumar , Parmar Shashank 
Published: October 2023

AIM AND OBJECTIVE: The aim of this study was to evaluate and compare the effect of various surface treatments on the microtensile bond strength of Lithium disilicate ceramic with dentin.
MATERIALS AND METHODS: A total of 45 human extracted premolars were obtained for the study. The samples were mounted in dental stone blocks having two “V” shaped notch on mesial and distal side of the mounted tooth. The samples were divided into three groups with 15 samples in each. The GROUP-A Control (without any surface treatment), GROUP-B (air abrasion with Al2O3 particles for 15 seconds) and GROUP-C (laser treatment for 5 seconds). Standardize tooth preparation was done on samples and lithium disilicate crowns were fabricated with a loop on occlusal surface. After surface treatment crowns were luted with self adhesive resin cement and pull out load test was performed in universal testing machine. The data was analysed using one way ANOVA TEST for multiple group comparison followed by Tusky HSD post hoc test. Level of significance was considered at 5% (p-value<0.05).
RESULTS: The surface treatment considerably increased the retention of lithium disilicate crowns. The air abrasion group showed the highest microtensile bond strength values. There was significant difference between air abrasion and laser treatment groups.
CONCLUSION: It was evident that microtensile bond strength was adequately increased after both the surface treatments (air abrasion with Al2O3 particles and laser treatment) and there was significant increase in bond strength with air abrasion with Al2O3 particles group when compared to laser treatment group.
Comparative Microscopic and Radiographic Evaluation of Proximal Marginal Integrity of CAD/CAM PMMA Crown and CAD/CAM Zirconia Monolithic Crown- An In-vitro Study
Authors: Dr diksha rajput  , Dr anup vyas  , Dr sumeet jain  , Dr kavita maru  , Dr komal bhatia  , Dr Smit Palan  
Published: October 2023

ABSTRACTS
Aim: to evaluate and compare proximal marginal integrity radiographically and microscopically of CAD/CAM PMMA crown and CAD/CAM monolithic zirconia crown.
Materials and methods: Fifteen maxillary or mandibular molar teeth with standardized anatomic preparation for provisional crown and monolithic zirconia crown were scanned with a 3-dimensional laboratory scanner. CAD/CAM crowns were designed 3-dimensionally using exocad software and then milled from presintered blocks in a milling machine. The proximal marginal integrity of CAD/CAM PMMA and monolithic zirconia crown were evaluated radiographically and microscopically. For radiographic evaluation, radiopaque dye is used to measured proximal marginal discrepancies on six reference points on PMMA crown. A digital microscope was used to measure the marginal discrepancies on six reference points on PMMA and zirconia crown. Photographs of the proximal marginal areas were captured at six reference lines at standardized orientation and placement of the samples. In all photographs margin was traced with the help of HiViewSetup software. The mean marginal discrepancies for each group were analysed using chi-square test and man whitney U test.
Results: the test result shows there were no significant differences in radiographic and microscopic evaluation of CAD/CAM PMMA crown and CAD/CAM monolithic zirconia crown.
Conclusion:
It is found that radiographically, PMMA crown had greater marginal discrepancy as compared to the Zirconia crown. Microscopically, PMMA crown and the CAD/CAM monolithic zirconia crown had almost similar marginal discrepancy (statistically non- significant).
Design, Synthesis, Molecular Docking and Cytotoxicity of Stilbene-arylcinnamide
Hybrids on A549 Lung Cancer Cells
Authors: Zaki Nurain Syazwani Mohd. , Mohamad Kamal Nik Nur Syazni Nik , Supratman Unang , Harneti Desi , Hassan Mohd. Zaheen , Mohamad Taib Mohamad Nurul Azmi 
Published: October 2023

Abstract:
A new series of stilbene-arylcinnamide hybrids have been designed and synthesized with various
substituents. These compounds were characterized by FTIR, 1D- and 2D-NMR as well as mass spectroscopy
analysis (HRESIMS). The synthesized compounds were tested for their cytotoxic activity against human lung
cancer A549 cell. The most active compound was further studied via in silico molecular docking on α,β-
interface of tubulin. Total 18 new stilbene-arylcinnamide hybrids have been synthesized with 42-80% yield
and evaluated for their cytotoxic activity against human lung cancer A549 cell. Particularly, compound 6b exhibited
potent cytotoxicity against A549 cells with the IC50 value of 19.9 μM. In addition, compound 7b displayed
moderate activities with the IC50 value of 33.9 μM, while other hybrids were considered inactive. Structural
activity relationship (SAR) studies revealed that the presence of an isopropyl group at the para position on
ring A and a methyl group at the para position on ring C is beneficial for enhanced cytotoxicity. Furthermore,
we also developed an in silico molecular docking to study the binding interaction of the active compounds to
the α,β-interface of tubulin (PDB ID: 3E22). Hybrids 6b and 7b demonstrated promising binding interactions
and affinities into the tubulin active site with calculated binding energy of -7.2 and -8.0 kcal/mol, respectively.
Nano-approaches and Recent Advancements in Strategies to Combat
Challenges Associated with Thyroid Cancer Therapies
Authors: Singh Gurmehar , Rathee Jatin , Triveni  , Jain Neha , Nagaich Upendra , Kaul Shreya , Pandey Manisha , Gorain Bapi 
Published: October 2023

Abstract:
The prevalence of thyroid cancer (TC) is more common in women and is up to 43% in patients aged between 45-65 years. The battle against TC is hampered by the lack of effective diagnostic
and therapeutic approaches. The effectiveness of surgical procedures, such as thyroidectomy and
nutraceutical treatments, are accompanied by several difficulties and still require further research. Alternatively, the DNA-damaging traditional model of chemotherapy is linked to poor solubility, untoward systemic effects, and associated cytotoxicity, instituting an urgent need to establish a specialized, factual, and reliable delivery tool. In order to overcome the limitations of conventional delivery
systems, nanotechnology-based delivery tools have shown the potential of articulating endless inherent implementations. The probable benefits of emerging nanotechnology-based diagnostic techniques
include rapid screening and early illness diagnosis, which draws investigators to investigate and assess
the possibility of this treatment for TC. Subsequently, organic (e.g., liposomes, polymer-based, and
dendrimers) and inorganic (e.g., gold, carbon-based, mesoporous silica, magnetic, and quantum dots)
NPs and hybrids thereof (liposome-silica, chitosan-carbon, and cell membrane-coated) have been projected for TC biomarker screening, therapy, and detection, providing better outcomes than traditional
diagnostic and treatment techniques. Therefore, this review aims to offer a broad perspective on nanoplatform in TC, accompanied by present and potential future treatment options and screening techniques. The goal of cancer therapy has traditionally been to "search a thorn in a hayloft"; therefore,
this article raises the possibility of treating TC using nano-oncotherapeutics, which might be useful
clinically and will encourage future researchers to explore this tool’s potential and drawbacks.
Pielęgnowanie pacjenta w chorobie wrzodowej żołądka i dwunastnicy
Authors: Duda Emilia 
Published: October 2023

Wstęp. Choroba wrzodowa żołądka i dwunastnicy ma charakter przewlekły i może prowadzić do poważnych powikłań, w tym zagrażających życiu.
Cel. Celem pracy była analiza zadań pielęgniarki w opiece nad pacjentem z chorobą wrzodową żołądka i dwunastnicy.
Prezentacja przypadku. Pacjent lat 44 przyjęty w trybie nagłym do szpitala na SOR z powodu krwawienia z górnego odcinka przewodu pokarmowego i bólu w klatce piersiowej. Tydzień temu pacjent zakończył ciąg alkoholowy. Po badaniu gastroskopowym potwierdzono wrzód żołądka i dwunastnicy oraz krwawienie z pękniętego wrzodu. Podjęto decyzję o operacji w trybie pilnym. Obecnie 1 doba pobytu chorego w oddziale chirurgii.
Wnioski. Problemy pacjenta z chorobą wrzodową żołądka i dwunastnicy są wyzwaniem dla chorego, jak i dla całego zespołu terapeutycznego sprawującego nad nim opiekę. Dominującymi problemami u chorego są: ryzyko wystąpienia ponownego krwotoku z przewodu pokarmowego, możliwość wystąpienia zaburzeń wodno-elektrolitowych, ryzyko zakażenia i rozejścia się brzegów rany po operacji, ból w okolicy rany, ryzyko wystąpienia powikłań układu oddechowego i pokarmowego po operacji, złe samopoczucie pacjenta z powodu nudności, deficyt samoopieki ze strony pacjenta, ryzyko wystąpienia niedożywienia u chorego, niepokój pacjenta o swój stan zdrowia, brak wiedzy na temat uwarunkowań choroby wrzodowej i jej związku z alkoholizmem.
Działania edukacyjne podejmowane przez pielęgniarkę wobec pacjenta z chorobą wrzodową żołądka i dwunastnicy w dążeniu do profilaktyki powikłań choroby i występowania jej zaostrzeń powinny koncentrować się na: motywowaniu do zmiany dotychczasowego stylu życia, rezygnacji z palenia tytoniu i zaprzestania picia alkoholu, stosowaniu się zasad samokontroli i terapii, w tym dietoterapii.
OPTIMIZATION OF PRIMARY PREVENTION MEANS OF ORAL TISSUES DISEASES IN MILITARY PERSONNEL OF THE ARMED FORCES OF UKRAINE
Authors: Lavrin O.Ya. 
Published: October 2023

Резюме. Специфічні умови життя і бойової діяльності особового складу Збройних Сил України, пов’язані з особливостями військової професії, мають вплив на перебіг патологічних процесів зубощелепного апарату, потребують відповідних методів профілактики та лікування.

Тому метою даної роботи став аналіз результатів впровадження програми первинної профілактики захворювань тканин ротової порожнини у військовослужбовців Збройних Сил України, яка оптимально була б використана в умовах проведення бойових дій.

Методи. Для оцінки стоматологічного статусу пацієнтів проведено клінічне стоматологічне обстеження 348 військовослужбовців віком 20-45 років. Гігієнічний стан ротової порожнини оцінювали за допомогою гігієнічних індексів J.C. Green, J.R. Vermillion (ОНІ-S), Федорова-Володкіної, АРІ. Всім пацієнтам надано рекомендації щодо догляду за ротовою порожниною на період ротації згідно індивідуально розробленої програми. Контрольні відвідування проводили через 3, 6, 9 та 12 місяців.

Результати дослідження. Під час первинного огляду у військовослужбовців 20-25 р. та 26-30 р. стан гігієни ротової порожнини відповідає задовільному рівню. У вікових групах 30-35, 36-40 та 41-45 р. відмічається поганий та незадовільний рівень гігієни згідно вказаних індексів. Через 6 місяців використання запропонованої програми первинної профілактики гігієнічний стан ротової порожнини обстежених покращився у всіх вікових групах. Через 12 місяців спостереження у обстежених вікових груп 20-25, 26-30, 31-35, 36-40 р. відмічали хороший рівень гігієни згідно вказаних індексів. Проте у віковій групі 41-45 р. констатовано задовільний рівень гігієни згідно індексів ОНІ- S та Федорова-Володкіної.

Висновок. Отже, можна зробити висновок, що під час планування заходів первинної профілактики захворювань тканин ротової порожнини необхідно враховувати особливості побуту пацієнтів, що особливо доцільним є у військовослужбовців, які перебувають в зоні проведення бойових дій.
Clinical Decision Support to Reduce Opioid Prescriptions for Dental Extractions using SMART on FHIR: Implementation Report
Authors: Rindal D Brad , Pasumarthi Dhavan Prasad , Thirumalai Vijayakumar , Truitt Anjali R , Asche Stephen E , Worley Donald C , Kane Sheryl M , Gryczynski Jan , Mitchell Shannon G 
Published: October 2023

Background
Clinical decision support (CDS) has the potential to improve clinical decision-making consistent with evidence-based care. CDS can be designed to save health care providers time and help them provide safe and personalized analgesic prescribing.

Objective
The aim of this report is to describe the development of a CDS system designed to provide dentists with personalized pain management recommendations to reduce opioid prescribing following extractions. The use of CDS is also examined.

Methods
This study was conducted in HealthPartners, which uses an electronic health record (EHR) system that integrates both medical and dental information upon which the CDS application was developed based on SMART (Substitutable Medical Applications and Reusable Technologies) on FHIR (Fast Healthcare Interoperability Resources). The various tools used to bring relevant medical conditions, medications, patient history, and other relevant data into the CDS interface are described. The CDS application runs a drug interaction algorithm developed by our organization and provides patient-specific recommendations. The CDS included access to the state Prescription Monitoring Program database.

Implementation (Results)
The pain management CDS was implemented as part of a study examining opioid prescribing among patients undergoing dental extraction procedures from February 17, 2020, to May 14, 2021. Provider-level use of CDS at extraction encounters ranged from 0% to 87.4% with 12.1% of providers opening the CDS for no encounters, 39.4% opening the CDS for 1%-20% of encounters, 36.4% opening it for 21%-50% of encounters, and 12.1% opening it for 51%-87% of encounters.

Conclusions
The pain management CDS is an EHR-embedded, provider-facing tool to help dentists make personalized pain management recommendations following dental extractions. The SMART on FHIR–based pain management CDS adapted well to the point-of-care dental setting and led to the design of a scalable CDS tool that is EHR vendor agnostic.

Trial Registration
ClinicalTrials.gov NCT03584789; https://clinicaltrials.gov/study/NCT03584789