bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mulheres artistas do surrealismo e contra-imaginário
Authors: Salvi Ana Carolina 
Published: January 2024

O trabalho pretende analisar algumas obras de Leonora Carrington, Remedios Varo e Leonor Fini, artistas vinculadas ao pensamento e/ou movimento surrealista. Observa-se como a poética feminista desenvolvida por elas ao longo da carreira contribuiu para a formação de um “contra-imaginário” transformador, seguindo o termo utilizado por Tânia Navarro-Swain, por sua vez inspirada em Gaston Bachelard, capaz de reformular significados culturais e operar na dissolução de relações de poder desiguais no que concerne questões de gênero e sexualidades. Animadas pelas ideias de um movimento propositivo à ruptura com as normas, elas exploraram e buscaram reformular os significados do feminino na cultura ocidental pelo mergulho em si mesmas, em outras mitologias e naquilo esquecido ou recusado pela racionalidade dominante – alquimia, misticismo, bestiário. Portanto, o texto visa debater, a partir das ideias e críticas feministas, a contribuição dessas obras para a formulação de um imaginário amigo das mulheres, isto é, filógino, como defende Margareth Rago.
The interplay between gingival crevicular fluid microbiome and metabolomic profile in intensively treated people with type 1 diabetes - a combined metagenomic/metabolomic approach cross-sectional study
Authors: Gregorczyk-Maga Iwona , Kania Michał , Dąbrowska Michalina , Samborowska Emilia , Żeber-Lubecka Natalia , Kulecka Maria , Klupa Tomasz 
Published: February 2024

AimsThis study aimed to assess the gingival crevicular fluid (GCF) microbiome and metabolome of adults with type 1 diabetes (T1D) treated with continuous subcutaneous insulin infusion (CSII).MethodsIn this cross-sectional study, the GCF of adults with T1D treated with CSII and non-diabetic controls were sampled, and metagenomic/metabolomic analyses were performed.ResultsIn total, 65 participants with T1D and 45 healthy controls with a mean age of 27.05 ± 5.95 years were investigated. There were 22 cases of mild gingivitis (G) in the T1D group. There were no differences considering the Shannon and Chao indices and β-diversity between people with T1D and G, with T1D without G, and healthy controls. Differential taxa were identified, which were mainly enriched in people with T1D and G. Acetic acid concentration was higher in people with T1D, regardless of the presence of G, than in healthy controls. Propionic acid was higher in people with T1D and G than in healthy controls. Isobutyric and isovaleric acid levels were higher in individuals with T1D and G than in the other two subgroups. The concentration of valeric acid was lower and that of caproic acid was higher in people with T1D (regardless of gingival status) than in healthy controls.ConclusionsThe identification of early changes in periodontal tissues by targeting the microbiome and metabolome could potentially enable effective prevention and initial treatment of periodontal disease in people with T1D.
Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study
Authors: Naja Khaled , Anwardeen Najeha , Malki Ahmed M. , Elrayess Mohamed A. 
Published: February 2024

BackgroundMetformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim of this study is to identify metabolic signatures associated with metformin treatment, which may explain the pleiotropic mechanisms by which metformin works, and could lead to an improved treatment and expanded use.MethodsThis is a cross-sectional study, in which clinical and metabolomic data for 146 patients with type 2 diabetes were retrieved from Qatar Biobank. Patients were categorized into: Metformin-treated, treatment naïve, and non-metformin treated. Orthogonal partial least square discriminate analysis and linear models were used to analyze differences in the level of metabolites between the metformin treated group with each of the other two groups.ResultsPatients on metformin therapy showed, among other metabolites, a significant increase in 3-hydroxyoctanoate and 3-hydroxydecanoate, which may have substantial effects on metabolism.ConclusionsThis is the first study to report an association between 3-hydroxy medium chain fatty acids with metformin therapy in patients with type 2 diabetes. This opens up new directions towards repurposing metformin by comprehensively understanding the role of these metabolites.
Developing the TeamOBS-vacuum-assisted delivery checklist to assess clinical performance in a vacuum-assisted delivery: a Delphi study with initial validation
Authors: Brogaard Lise , Hinshaw Kim , Kierkegaard Ole , Manser Tanja , Uldbjerg Niels , Hvidman Lone 
Published: February 2024

IntroductionIn Northern Europe, vacuum-assisted delivery (VAD) accounts for 6–15% of all deliveries; VAD is considered safe when conducted by adequately trained personnel. However, failed vacuum extraction can be harmful to both the mother and child. Therefore, the clinical performance in VAD must be assessed to guide learning, determine a performance benchmark, and evaluate the quality to achieve an overall high performance. We were unable to identify a pre-existing tool for evaluating the clinical performance in real-life vacuum-assisted births.ObjectiveWe aimed to develop and validate a checklist for assessing the clinical performance in VAD.MethodsWe conducted a Delphi process, described as an interactive process where experts answer questions until answers converge toward a “joint opinion” (consensus). We invited international experts as Delphi panelists and reached a consensus after four Delphi rounds, described as follows: (1) the panelists were asked to add, remove, or suggest corrections to the preliminary list of items essential for evaluating clinical performance in VAD; (2) the panelists applied weights of clinical importance on a Likert scale of 1–5 for each item; (3) each panelist revised their original scores after reviewing a summary of the other panelists’ scores and arguments; and (4) the TeamOBS-VAD was tested using videos of real-life VADs, and the Delphi panel made final adjustments and approved the checklist.ResultsTwelve Delphi panelists from the UK (n = 3), Norway (n = 2), Sweden (n = 3), Denmark (n = 3), and Iceland (n = 1) were included. After four Delphi rounds, the Delphi panel reached a consensus on the checklist items and scores. The TeamOBS-VAD checklist was tested using 60 videos of real-life vacuum extractions. The inter-rater agreement had an intraclass correlation coefficient (ICC) of 0.73; 95% confidence interval (95% CI) of [0.58, 0.83], and that for the average of two raters was ICC 0.84 95% CI [0.73, 0.91]. The TeamOBS-VAD score was not associated with difficulties in delivery, such as the number of contractions during vacuum extraction delivery, cephalic level, rotation, and position. Failed vacuum extraction occurred in 6% of the video deliveries, but none were associated with the teams with low clinical performance scores.ConclusionThe TeamOBS-VAD checklist provides a valid and reliable evaluation of the clinical performance of vaginal-assisted vacuum extraction.
Significant association of elevated serum galectin-9 levels with the development of non-alcoholic fatty liver disease in patients with rheumatoid arthritis
Authors: Chen Po-Ku , Hsu Wei-Fan , Peng Cheng-Yuan , Liao Tsai-Ling , Chang Shih-Hsin , Chen Hsin-Hua , Chen Chu-Huang , Chen Der-Yuan 
Published: February 2024

BackgroundNon-alcoholic fatty liver disease (NAFLD) is prevalent among rheumatoid arthritis (RA) patients, but its pathogenesis has rarely been explored. Galectin-9 (Gal-9) interacts with T cell immunoglobulin and mucin-containing-molecule-3 (TIM-3) expressed on hepatocytes and thus regulates T cell proliferation in a murine model of NAFLD. We aimed to examine the pathogenic role of the Gal-9/TIM-3 pathway in RA-NAFLD.MethodsSerum levels of Gal-9, soluble TIM-3 (sTIM-3), fatty acid-binding proteins (FABP)1, and FABP4 were determined by ELISA in forty-five RA patients and eleven healthy participants. Using Oil-red O staining and immunoblotting, we examined the effects of Gal-9 and free fatty acid (FFA) on lipid accumulation in human hepatocytes and FABP1 expression.ResultsSerum Gal-9, sTIM-3 and FABP1 level were significantly higher in RA patients (median 5.02 ng/mL, 3.42 ng/mL, and 5.76 ng/mL, respectively) than in healthy participants (1.86 ng/mL, 0.99 ng/mL, and 0.129 ng/mL, all p &lt; 0.001). They were also significantly higher in patients with moderate-to-severe NAFLD compared with none-to-mild NAFLD (p &lt; 0.01; p &lt; 0.05; and p &lt; 0.01, respectively). Serum Gal-9 levels were positively correlated with sTIM-3, FABP1, FABP4 levels, and ultrasound-fatty liver score, respectively, in RA patients. Multivariate regression analysis revealed that Gal-9 (cut-off&gt;3.30) was a significant predictor of NAFLD development, and Gal-9 and sTIM-3 were predictors of NAFLD severity (both p &lt; 0.05). The cell-based assay showed that Gal-9 and FFA could upregulate FABP1 expression and enhance lipid droplet accumulation in hepatocytes.ConclusionElevated levels of Gal-9 and sTIM3 in RA patients with NAFLD and their positive correlation with NAFLD severity suggest the pathogenic role of Gal-9 signaling in RA-related NAFLD.
Real-world observations and impacts of Chinese herbal medicine for migraine: results of a registry-based cohort study
Authors: Lyu Shaohua , Zhang Claire Shuiqing , Zhang Anthony Lin , Guo Xinfeng , Hua Rong , Mao Zhenhui , Su Qiaozhen , Xue Charlie Changli , Sun Jingbo 
Published: February 2024

Background: Migraine is a prevalent, recurrent condition with substantial disease burden. Chinese herbal medicine (CHM) has been used frequently for migraine in controlled clinical settings. This study is to summarise the characteristics of patients who seek clinical care in a tertiary Chinese medicine hospital in China; to gather their preferences and values of using CHM; to explore the effect of CHM for migraine and its comorbidities in a real-world setting, and to collect first-hand expertise of clinicians’ practice pattern in prescribing CHM for migraine.Methods: This registry-based cohort study was prospectively conducted at Guangdong Provincial Hospital of Chinese Medicine from December 2020 to May 2022. Adult migraine patients seeking their initial anti-migraine clinical care at the hospital were consecutively recruited and followed up for 12 weeks. Practitioners specialised in headache management prescribed individualised treatments without research interference. Standardised case report forms were employed to gather information on patients’ preferences and perspective of seeking clinical care, as well as to assess participants’ migraine severity, comorbidities, and quality of life, at 4-weeks intervals. Various analytical methods were utilised based on the computed data.Results: In this study, we observed 248 participants. Of these, 73 received CHM treatment for 28 days or longer. Notably, these participants exhibited a greater disease severity, compared to those treated with CHM for less than 28 days. Of the 248 participants, 83.47% of them expected CHM would effectively reduce the severity of their migraine, around 50% expected effects for migraine-associated comorbidities, while 51.61% expressing concerns about potential side effects. CHM appeared to be effective in reducing monthly migraine days and pain intensity, improving patients’ quality of life, and potentially reducing comorbid anxiety, with a minimum of 28 days CHM treatment. Herbs such as gan cao, gui zhi, chuan xiong, fu ling, bai zhu, yan hu suo, etc. were frequently prescribed for migraine, based on patients’ specific symptoms.Conclusion: CHM appeared to be beneficial for migraine and comorbid anxiety in real-world clinical practice when used continuously for 28 days or more.Clinical Trial Registration:clinicaltrials.gov, identifier ChiCTR2000041003.
Grading by AI makes me feel fairer? How different evaluators affect college students’ perception of fairness
Authors: Chai Fangyuan , Ma Jiajia , Wang Yi , Zhu Jun , Han Tingting 
Published: February 2024

IntroductionIn the field of education, new technologies have enhanced the objectivity and scientificity of educational evaluation. However, concerns have been raised about the fairness of evaluators, such as artificial intelligence (AI) algorithms. This study aimed to assess college students’ perceptions of fairness in educational evaluation scenarios through three studies using experimental vignettes.MethodsThree studies were conducted involving 172 participants in Study 1, 149 in Study 2, and 145 in Study 3. Different evaluation contexts were used in each study to assess the influence of evaluators on students’ perception of fairness. Information transparency and explanations for evaluation outcomes were also examined as potential moderators.ResultsStudy 1 found that different evaluators could significantly influence the perception of fairness under three evaluation contexts. Students perceived AI algorithms as fairer evaluators than teachers. Study 2 revealed that information transparency was a mediator, indicating that students perceived higher fairness with AI algorithms due to increased transparency compared with teachers. Study 3 revealed that the explanation of evaluation outcomes moderated the effect of evaluator on students’ perception of fairness. Specifically, when provided with explanations for evaluation results, the effect of evaluator on students’ perception of fairness was lessened.DiscussionThis study emphasizes the importance of information transparency and comprehensive explanations in the evaluation process, which is more crucial than solely focusing on the type of evaluators. It also draws attention to potential risks like algorithmic hegemony and advocates for ethical considerations, including privacy regulations, in integrating new technologies into educational evaluation systems. Overall, this study provides valuable theoretical insights and practical guidance for conducting fairer educational evaluations in the era of new technologies.
Nexus between farmland transfer, agricultural loans, and grain production: empirical evidence from China
Authors: Ding Zhao , Zhang Qianyu , Tang Yu 
Published: February 2024

IntroductionFood production stands as a critical global concern necessitating comprehensive investigation. This study utilizes provincial-level data from China to explore the intricate relationships between farmland transfer, agricultural loans, and grain production, with the aim of shedding light on the complexities of these dynamics.MethodsA two-way fixed effects model and instrumental variable approach are applied to assess the interplay between farmland transfer, agricultural loans, and grain production. These methods provide a robust framework for understanding the complex relationships among these variables.Results and discussionThe study reveals a notable positive correlation between farmland transfer and grain production. Conversely, agricultural loans demonstrate a significantly negative impact on grain production. However, the positive interaction term between farmland transfer and agricultural loans suggests a nuanced relationship. While profit-driven financial activities may not inherently favor grain production, they contribute to more efficient utilization of farmland resources, ultimately promoting grain production. The findings underscore the significance of continued government support for rural land system reform and active guidance of farmland transfer. It is emphasized that a moderate-scale operation of farmland is crucial for finance to play a lubricating and catalytic role. Furthermore, there is a need to guide agricultural finance towards investing in medium and long-term projects of agricultural production. Attention is also directed to preventing potential food crises arising from the phenomenon of “non- farming” associated with agricultural loans.
A young woman with atypical McCune–Albright syndrome and the difficult road to recovery: a case report
Authors: Wang Hongbin , Wang Hao , Liu Heng , Yang Xin , Meng Zhichao , Cao Yongping 
Published: February 2024

BackgroundFiber dysplasia is a complex condition that presents with various clinical manifestations, such as deformity, dysfunction, pathological fractures, and endocrine disorders. McCune–Albright syndrome (MAS) is a rare subtype of fiber dysplasia. This article reports a case of atypical McCune–Albright syndrome in a patient with a femoral neck fracture.Case presentationA patient with atypical McCune–Albright syndrome sustained a right femoral neck fracture and underwent multiple treatments, including total hip replacement, intravenous infusion of zoledronic acid, oral calcium supplementation, right supracondylar osteotomy, orthopedic surgery, plate and screw internal fixation for a left femoral shaft fracture, and removal of the right femoral plate. The patient also developed a submaxillary infection complicated by mandibular osteonecrosis.ConclusionPatients with MAS may experience rare complications as a result of their unique condition, regardless of whether they receive drug or surgical treatment. Therefore, personalized drug regimens and feasible surgical options are necessary.
Molecular Rapid Test for Identification of Tuna Species
Authors: Gkini Isidora P. , Christopoulos Panagiotis , Conides Alexis , Kalogianni Despina P. , Christopoulos Theodore K. 
Published: February 2024

Tuna is an excellent food product, relatively low in calories, that is recommended for a balanced diet. The continuously increasing demand, especially for bluefin-tuna-based food preparations, and its relatively high market price make adulteration by intentionally mixing with other lower-priced tunas more prospective. The development of rapid methods to detect tuna adulteration is a great challenge in food analytical science. We have thus developed a simple, fast, and low-cost molecular rapid test for the visual detection of tuna adulteration. It is the first sensor developed for tuna authenticity testing. The three species studied were Thunnus thynnus (BFT), Thunnus albacares, and Katsuwonus pelamis. DNA was isolated from fresh and heat-treated cooked fish samples followed by PCR. The PCR products were hybridized (10 min) to specific probes and applied to the rapid sensing device. The signal was observed visually in 10–15 min using gold nanoparticle reporters. The method was evaluated employing binary mixtures of PCR products from fresh tissues and mixtures of DNA isolates from heat-treated tissues (canned products) at adulteration percentages of 1–100%. The results showed that the method was reproducible and specific for each tuna species. As low as 1% of tuna adulteration was detected with the naked eye.
Predicting Long-Term Endothelial Cell Loss after Preloaded Descemet Membrane Endothelial Keratoplasty in Fuchs’ Endothelial Corneal Dystrophy: A Mathematical Model
Authors: Viola Pietro , Neri Enrico , Occhipinti Tommaso , Parekh Mohit , Cian Roberto , Ponzin Diego , Moramarco Antonio , Iovieno Alfonso 
Published: February 2024

(1) Background: This study offers a biexponential model to estimate corneal endothelial cell decay (ECD) following preloaded “endothelium-in” Descemet membrane endothelial keratoplasty (DMEK) in Fuchs’ endothelial corneal dystrophy (FECD) patients; (2) Methods: A total of 65 eyes undergoing DMEK alone or combined with cataract surgery were evaluated. The follow-up period was divided into an early phase (first 6 months) and a late phase (up to 36 months). Endothelial cell count (ECC) and endothelial cell loss (ECL) were analyzed; (3) Results: The half time of the ECD was 3.03 months for the early phase and 131.50 months for the late phase. The predicted time-lapse interval to reach 500 cells/mm2 was 218 months (18.17 years), while the time-lapse interval to reach 250 cells/mm2 was 349 months (29.08 years). There was no statistically significant difference between the ECL in DMEK combined with cataract extraction and DMEK alone at 24 months (p ≥ 0.20). At the late phase, long-term ECL prediction revealed a lower ECC half time in patients undergoing DMEK combined with cataract surgery (98.05 months) than DMEK alone (250.32 months); (4) Conclusions: Based on the mathematical modeling, a predicted average half-life of a DMEK graft could reach 18 years in FECD. Moreover, combining cataract extraction with DMEK could result in excessive ECL in the long term.
Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function
Authors: Bhattarai Dinesh , Lee Seong-Ok , Joshi Neelam , Jun Se-Ran , Lo Sorena , Jiang Li , Gokden Neriman , Parajuli Nirmala 
Published: February 2024

Key Points

Cold storage (CS) increases the severity of graft dysfunction in a time-dependent manner, and prolonged CS decreases animal survival.CS plus transplant increases iproeasome levels/assembly in renal allografts; IFN-γ is a potential inducer of the iproteasome.Inhibiting iproteasome ex vivo during renal CS did not confer graft protection after transplantation.

Background
It is a major clinical challenge to ensure the long-term function of transplanted kidneys. Specifically, the injury associated with cold storage (CS) of kidneys compromises the long-term function of the grafts after transplantation. Therefore, the molecular mechanisms underlying CS-related kidney injury are attractive therapeutic targets to prevent injury and improve long-term graft function. Previously, we found that constitutive proteasome function was compromised in rat kidneys after CS followed by transplantation. Here, we evaluated the role of the immunoproteasome (iproteasome), a proteasome variant, during CS followed by transplantation.

Methods
Established in vivo rat kidney transplant model with or without CS containing vehicle or iproteasome inhibitor (ONX 0914) was used in this study. The iproteasome function was performed using rat kidney homogenates and fluorescent-based peptide substrate specific to β5i subunit. Western blotting and quantitative RT-PCR were used to assess the subunit expression/level of the iproteasome (β5i) subunit.

Results
We demonstrated a decrease in the abundance of the β5i subunit of the iproteasome in kidneys during CS, but β5i levels increased in kidneys after CS and transplant. Despite the increase in β5i levels and its peptidase activity within kidneys, inhibiting β5i during CS did not improve graft function after transplantation.

Summary
These results suggest that the pharmacologic inhibition of immunoproteasome function during CS does not improve graft function or outcome. In light of these findings, future studies targeting immunoproteasomes during both CS and transplantation may define the role of immunoproteasomes on short-term and long-term kidney transplant outcomes.