bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurses’ Role and Understanding of the Application of Antimicrobial Stewardship Principles in Hematology Settings
Authors: Sangojoyo Jennie , Hutchinson Ana , Cohen Emma , Bouchoucha Stéphane L. 
Published: December 2023

Background:
Patients with hematological malignancies are highly susceptible to infection due to the disease process and/or administration of immunosuppressive therapies. Judicious use of antimicrobial therapies based on antimicrobial stewardship (AMS) principles and early recognition and response to sepsis are essential.

Objective:
To explore hematology nurses’ understanding of the application of AMS principles in hematology settings and their experience of using a nurse-initiated neutropenic sepsis pathway.

Methods:
A qualitative exploratory descriptive study using focus groups with 18 participants.

Results:
Three themes emerged: (1) nurses taking the lead in sepsis management; (2) timely management of neutropenic sepsis; and (3) Nurses’ knowledge of AMS principles. Associated subthemes were (1) nurse empowerment and leadership through implementation of a nurse-initiated pathway; (2) nurses’ role in supporting system processes and assessing treatment response; and (3) nurses’ knowledge of commonly used antimicrobials and the need for resources to support clinical decision-making.

Conclusions:
Although many participants were not familiar with the term AMS, nurses recognized their role and demonstrated leadership in early recognition and timely antimicrobial therapy.

Implications for Practice:
This study shows that nurse-led pathways improve patient outcomes and enable nurses to administer timely care in neutropenic sepsis. Findings also show that these pathways enable nurses to demonstrate their infection prevention and control leadership.

What is Foundational:
Despite knowledge gaps in nurses’ AMS, clinical pathways embedding AMS principles empowered nurses to play an active leadership role. Barriers to early treatment of neutropenic sepsis can be overcome when using dedicated pathways.
Better Nurse Practitioner Primary Care Practice Environments Reduce Hospitalization Disparities Among Dually-Enrolled Patients
Authors: Nikpour Jacqueline , Brom Heather , Mason Aleigha , Chittams Jesse , Poghosyan Lusine , Brooks Carthon Margo 
Published: December 2023

Background:
Over 12 million Americans are dually enrolled in Medicare and Medicaid. These individuals experience over twice as many hospitalizations for chronic diseases such as coronary artery disease and diabetes compared with Medicare-only patients. Nurse practitioners (NPs) are well-positioned to address the care needs of dually-enrolled patients, yet NPs often work in unsupportive clinical practice environments. The purpose of this study was to examine the association between the NP primary care practice environment and hospitalization disparities between dually-enrolled and Medicare-only patients with chronic diseases.

Methods:
Using secondary cross-sectional data from the Nurse Practitioner Primary Care Organizational Climate Questionnaire and Medicare claims files, we examined 135,648 patients with coronary artery disease and/or diabetes (20.0% dually-eligible, 80.0% Medicare-only), cared for in 450 practices employing NPs across 4 states (PA, NJ, CA, FL) in 2015. We compared dually-enrolled patients’ odds of being hospitalized when cared for in practice environments characterized as poor, mixed, and good based on practice-level Nurse Practitioner Primary Care Organizational Climate Questionnaire scores.

Results:
After adjusting for patient and practice characteristics, dually-enrolled patients in poor practice environments had the highest odds of being hospitalized compared with their Medicare-only counterparts [odds ratio (OR): 1.48, CI: 1.37, 1.60]. In mixed environments, dually-enrolled patients had 27% higher odds of a hospitalization (OR: 1.27, CI: 1.12, 1.45). However, in the best practice environments, hospitalization differences were nonsignificant (OR: 1.02, CI: 0.85, 1.23).

Conclusions:
As policymakers look to improve outcomes for dually-enrolled patients, addressing a modifiable aspect of care delivery in NPs’ clinical practice environment is a key opportunity to reduce hospitalization disparities.
Digital health innovations in urology: telemedicine, wearables, and mobile applications – a systematic review of literature
Authors: Naik Nithesh , Talyshinskii Ali , Rassweiler Jens , Hameed B.M. Zeeshan , Somani Bhaskar K. 
Published: December 2023

Purpose of review
There are enough publications on the use of telemedicine, wearable devices, and mobile applications in urology; however, their collective impact on urological care has not been adequately studied. This review seeks to address this deficiency by providing a descriptive analysis of the recent use of telemedicine, wearable technology, and mobile applications in urology as well as elucidating their associated challenges.

Recent findings
There are studies that were dedicated to the use of telemedicine, wearables, and mobile apps in urology according to inclusion criteria, respectively. They were successfully implemented in different urological subfields, such as urogynecology, endourology, pediatric urology, and uro-oncology, and led to time safety, remote monitoring, and better patient awareness. However, several concerns also exist, such as issues with data safety, measurement deviations, technical limitations, and lack of
quality.

Summary
Telemedicine, wearables, and mobile apps have already shown their potential in urological practice. However, further studies are needed to expand both our understanding of their current state and their potential for further development and clinical use.
Sex Estimation From Measurements of the Mastoid Triangle and Volume of the Mastoid Air Cell System Using Classical and Machine Learning Methods
Authors: Sasani Hadi , Etli Yasin , Tastekin Burak , Hekimoglu Yavuz , Keskin Siddik , Asirdizer Mahmut 
Published: December 2023

Abstract
Previous studies on the sexual dimorphism of the mastoid triangle have typically focused on linear and area measurements. No studies in the literature have used mastoid air cell system volume measurements for direct anthropological or forensic sex determination. The aims of this study were to investigate the applicability of mastoid air cell system volume measurements and mastoid triangle measurements separately and combined for sex estimation, and to determine the accuracy of sex estimation rates using machine learning algorithms and discriminant function analysis of these data. On 200 computed tomography images, the distances constituting the edges of the mastoid triangle were measured, and the area was calculated using these measurements. A region-growing algorithm was used to determine the volume of the mastoid air cell system. The univariate sex determination accuracy was calculated for all parameters. Stepwise discriminant function analysis was performed for sex estimation. Multiple machine learning methods have also been used. All measurements of the mastoid triangle and volumes of the mastoid air cell system were higher in males than in females. The accurate sex estimation rate was determined to be 79.5% using stepwise discriminant function analysis and 88.5% using machine learning methods.
Dentists’ Attitudes to the Preprocedural Safety Checklist “Time-Out” in Saudi Arabia
Authors: Rocchettta Davide , Hassan Syed Sirajul , Gray Jenny 
Published: December 2023

Objectives
Before performing medical procedures, there is a patient safety initiative process (also referred to as “time-out”), part of this process is the use of a preprocedural safety checklist. This initiative was envisioned by the World Health Organization, supported by various accreditation bodies who include the process in their standards. Dentistry lags behind its medical colleagues in using it presurgical or invasive procedure. Our aim was to understand dentists’ attitudes and knowledge about the process and their adherence to it.

Methods
A cross-sectional questionnaire was distributed between September and December 2021 and 102 dentists responded.

Results
Seventy three of the respondents (71.5%) claimed to be familiar with the time-out process, and 87 (85.3%) felt that it was an important or somewhat important process; however, only 62 (60.7%) were always performing the process before surgical or invasive outpatient procedures.

Conclusions
Patient safety must be given priority, as such it has been shown that preprocedural checklists help reduce medical errors. Recognizing the value of performing such a process, accreditation bodies have included the process in their standards and indeed in the Joint Commission focused patient safety goals.
Patient-centered health care planning in acute inpatient mental health settings: a best practice implementation project
Authors: Gagiu Corina , Mazilu Doina C. , Zazu Mariana , Nedelcu Viorica , Jitianu Dorinela A. , Manea Mirela , Vrbová Tereza , Klugar Miloslav , Klugarová Jitka 
Published: December 2023

ABSTRACT

Objectives:
The current project aimed to improve the quality of health care by promoting evidence-based practice (EBP) regarding mental health care planning (MHCP) for adult inpatients.

Introduction:
The implementation of the best evidence in the process of developing and documenting nursing care plans is currently an important legal requirement that contributes to increasing the quality of care.

Methods:
This implementation project was based on the JBI evidence implementation approach and included a baseline audit of seven criteria, implementation of strategies, and a follow-up audit. The project was conducted in an acute psychiatric setting at a university hospital in Bucharest, Romania. The sample included 17 nurses and 30 ward patients.

Results:
The baseline audit revealed low compliance (33%–37%) for criterion 3 (a comprehensive care plan) and criterion 4 (patient involvement); moderate compliance (55%) for criterion 1 (care plan for all patients); and increased compliance (97%–100%) for criterion 2 (assessment of patient's needs), criterion 5 (education of patients/caregivers), criterion 6 (providing a copy at discharge), and criterion 7 (education of professionals). As a result of implementing the most appropriate strategies, the maximum improvement (100%) was observed across all five audit criteria that were found to be deficient in the baseline audit.

Conclusion:
The development and implementation of strategies adapted to specific care need to play a key role in the implementation of EBP. In this case, educating nurses, facilitating nurses’ access to EBP for care planning, and improving procedures proved effective in achieving maximum compliance with all the audit criteria.
Implementation of virtual music therapy in the practice of Czech music therapists: a best practice implementation project
Authors: Kantor Jiří , Neuwirthová Anna , Hořejší Barbora , Koucun Jan , Kantorová Lucia , Vrbová Tereza , Munn Zachary , Klugarová Jitka , Klugar Miloslav 
Published: December 2023

ABSTRACT

Introduction and aims:
Czech music therapists lacked the skills and knowledge to adapt their practice to virtual music therapy (VMT) at the beginning of the COVID-19 pandemic, when physical contact was restricted. The aims of this project were to implement the best evidence-based recommendations concerning VMT in the practice of Czech music therapists and increase the number of therapists using VMT.

Methods:
The project used the JBI Evidence Implementation Framework to promote change in the practice of participants. A baseline audit of 26 practitioners was conducted using questionnaires and interviews. The audit criteria consisted of 8 best practice recommendations, followed by the implementation of targeted strategies and a follow-up audit.

Results:
Of the 26 music therapists, 18 began practicing VMT following the rollout of the implementation strategies. Strategies included educational workshops, instructional materials, technological support, individual counseling, and interactive training sessions. There was an increase in compliance with all audit criteria. The most critical barriers were lack of knowledge about VMT and lack of technical skills; lack of resources; technological challenges; low confidence of music therapists to provide VMT; and reduced need for VMT after the lockdown restrictions were relaxed.

Conclusions:
The implementation project helped to overcome temporary pandemic restrictions, increase the quality of VMT practice, develop strategies for VMT training, and identify reasons for using VMT during the pandemic and beyond.
Identification of conserved gene expression programs activated in multiple modes of torpor across vertebrate clades
Authors: Weir Kurt , Vega Natasha , Busa Veronica F. , Sajdak Ben , Kallestad Les , Merriman Dana , Palczewski Krzysztof , Carroll Joseph , Blackshaw Seth 
Published: December 2023

ABSTRACTTorpor encompasses adaptations to diverse extreme environmental stressors such as hibernation, aestivation, brumation, and daily torpor. Here we introduce StrokeofGenus, an analytic pipeline that identifies distinct transcriptomic states and conservation of gene expression patterns across studies, tissues, and species. We use StrokeofGenus to study multiple and diverse forms of torpor from publicly available RNA-seq datasets that span eight species and two classes. We identify three transcriptionally distinct states during the cycle of heterothermia: euthermia, torpor, and interbout arousal. We also identify torpor-specific gene expression patterns that are conserved both across tissues and between species with over three hundred million years of evolutionary divergence. We further demonstrate the general conservation of gene expression patterns in multiple forms of torpor, implying a common evolutionary origin for this process. Although here we apply StrokeofGenus to analysis of torpor, it can be used to interrogate any other complex physiological processes defined by transient transcriptomic states.HIGHLIGHTSStrokeofGenus integrates orthologue annotation, non-negative matrix factorization, and transfer learning for cross-species analysis.StrokeofGenus identifies conserved topor-related gene expression patterns across divergent species and cell types.Heterothermia has three distinct transcriptomic states.Torpor-specific gene expression patterns are conserved between species and forms of torpor.
Pollutome complexity determines the removal of recalcitrant pharmaceuticals
Authors: Suleiman Marcel , Lay Natalie Le , Demaria Francesca , Kolvenbach Boris A , Cretoiu Mariana S , Petchey Owen L , Jousset Alexandre , Corvini Philippe F-X 
Published: December 2023

AbstractOrganic pollutants are an increasing threat for wildlife and humans. Managing their removal is however complicated by the difficulties in predicting degradation rates. In this work we demonstrate that the complexity of the pollutome, the set of co-existing contaminants, is a major driver of biodegradation. We built representative assemblages out of one to five common pharmaceuticals (caffeine, atenolol, paracetamol, ibuprofen, and enalapril) selected along a gradient of biodegradability. We followed their individual removal by wastewater microbial communities. The presence of multichemical background pollution was essential for the removal of recalcitrant molecules such as ibuprofen. Crucially, high order interactions between pollutants were a determinant, with the addition of new molecules particularly impacting assemblages of multiple compounds. We explain these interactions by shifts in the microbiome, with degradable molecules such as paracetamol enriching species and pathways involved in the removal of several organic molecules. We conclude that pollutants should be treated as part of a complex system, with emerging pollutants potentially showing cascading effects and offering leverage to promote bioremediation.
Differences in clamp loader mechanism between bacteria and eukaryotes
Authors: Landeck Jacob T. , Pajak Joshua , Norman Emily K. , Sedivy Emma L. , Kelch Brian A. 
Published: December 2023

SUMMARYClamp loaders are pentameric ATPases that place circular sliding clamps onto DNA, where they function in DNA replication and genome integrity. The central activity of a clamp loader is the opening of the ring-shaped sliding clamp, and the subsequent binding to primer-template (p/t)-junctions. The general architecture of clamp loaders is conserved across all life, suggesting that their mechanism is retained. Recent structural studies of the eukaryotic clamp loader Replication Factor C (RFC) revealed that it functions using a crab-claw mechanism, where clamp opening is coupled to a massive conformational change in the loader. Here we investigate the clamp loading mechanism of theE. coliclamp loader at high resolution using cryo-electron microscopy (cryo-EM). We find that theE. coliclamp loader opens the clamp using a crab-claw motion at a single pivot point, whereas the eukaryotic RFC loader uses motions distributed across the complex. Furthermore, we find clamp opening occurs in multiple steps, starting with a partly open state with a spiral conformation, and proceeding to a wide open clamp in a surprising planar geometry. Finally, our structures in the presence of p/t-junctions illustrate how clamp closes around p/t-junctions and how the clamp loader initiates release from the loaded clamp. Our results reveal mechanistic distinctions in a macromolecular machine that is conserved across all domains of life.
Correlations of structural shocks, dynamic responses of output and inflation to commodities price shocks and monetary union in WAMZ
Authors: Abdul Rahman Yahuza , Osei-Fosu Anthony Kofi , Sakyi Daniel 
Published: December 2023

PurposeThis paper examines correlations of the underlying structural shocks and the degree of synchronization in the impulse responses of output, inflation and trade to a one standard deviation shock to non-oil commodities price index and exchange rates within the West African Monetary Zone (WAMZ) countries from 1990q1 to 2020q1.Design/methodology/approachThis paper uses the structural vector autoregressive model to isolate the underlying structural shocks and compares them with the West African Monetary Union (WAEMU) countries.FindingsFindings from the study suggest that correlations of underlying structural shocks are more profound in the WAEMU than in the WAMZ. Impulse responses of output to price and exchange rate shocks are more symmetric in the WAEMU than in the WAMZ. However, impulse responses of inflation to price and exchange rate shocks are symmetric in the WAMZ than in the WAEMU and responses of trade in both sub-groups are not uniform.Practical implicationsThe paper concludes that the WAMZ does not constitute an Optimum Currency Area concerning the correlations of the structural shocks and output. However, it has achieved convergence in inflation and there are adequate adjustment mechanisms to shocks in the WAMZ than in the WAEMU. Therefore, the WAMZ may not suffer from joining the monetary union. Thus, economic Community of West African States may take steps to roll out the monetary union.Originality/valueThe paper examines correlations of the underlying structural shocks, impulse responses of output and inflation to shocks to commodities price and exchange rates in the WAMZ and compares them with the WAEMU.
How click-like and online trust matter across generations of bank customers
Authors: Tran Lobel Trong Thuy 
Published: December 2023

PurposeThis article aims to explore the impact of interpersonal relationship stimuli and click-like on purchase intention across different generations of bank customers, with a focus on the moderating effect of online trust.Design/methodology/approachThe sample consists of 435 online bank customers from the Facebook community and the data collection was conducted using an online survey method. The model estimation utilized the partial least squares technique, along with multigroup analysis and importance-performance map analysis.FindingsThe empirical evidence supports the hypothesized relationships between interpersonal relationship stimuli, click-like and purchase intention, but varies across different generations and is contingent upon online trust. The analysis reveals commonalities in how Generation Z, Millennials and Generation X respond to interpersonal relationship stimuli while exhibiting distinct responses to click-like.Research limitations/implicationsThe empirical evidence confirms the hypothesized relationships between interpersonal relationship stimuli, click-like and purchase intention. However, these relationships exhibit variations across different generations and are contingent upon the level of online trust. The analysis highlights shared responses to interpersonal relationship stimuli among Generation Z, Millennials and Generation X, while also revealing distinct reactions to click-like within these generational groups.Originality/valueThis research investigates the collective impact of interpersonal relationship stimuli and click-like on purchase intention, taking into account the moderating role of online trust within various generational cohorts in the banking sector.
United we stand: a principle-based negotiation training for collective bargaining
Authors: Mann Michel , Warsitzka Marco , Hüffmeier Joachim , Trötschel Roman 
Published: December 2023

Purpose
This study aims to identify effective behaviors in labor-management negotiation (LMN) and, on that basis, derive overarching psychological principles of successful negotiation in this important context. These empirical findings are used to develop and test a comprehensive negotiation training program.

Design/methodology/approach
Twenty-seven practitioners from one of the world’s largest labor unions were interviewed to identify the requirements of effective LMN, resulting in 796 descriptions of single behaviors from 41 negotiation cases.

Findings
The analyses revealed 13 categories of behaviors critical to negotiation success. The findings highlight the pivotal role of the union negotiator by illustrating how they lead the negotiations with the other party while also ensuring that their own team and the workforce stand united. To provide guidance for effective LMN, six psychological principles were derived from these behavioral categories. The paper describes a six-day training program developed for LMN based on the empirical findings of this study and the related six principles.

Originality/value
This paper has three unique features: first, it examines the requirements for effective LMN based on a systematic needs assessment. Second, by teaching not only knowledge and skills but also general psychological principles of successful negotiation, the training intervention is aimed at promoting long-term behavioral change. Third, the research presents a comprehensive and empirically-based training program for LMN.