bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Radiographic Talar Loosening Rates Between Salto-Talaris and INBONE II
Authors: Anastasio Albert T. , Adams Samuel B. , DeOrio James K. , Easley Mark E. , Nunley James A. , Lee Dong-Oh 
Published: November 2023

Background: Despite substantial increase in total ankle arthroplasty (TAA) nationwide, there are few studies comparing flat-cut vs chamfer-cut talar systems in TAA with regard to radiographic aseptic loosening rates of the implant. Methods: This retrospective study included 189 Salto-Talaris TAA and 132 INBONE II primary TAA with a minimum 1-year follow-up. Patient characteristics were obtained including gender, age at surgery, body mass index (BMI), smoking status, primary diagnosis, surgical time, and the presence of diabetes. Radiographic evidence for aseptic loosening was assessed. Statistical analysis was performed for comparison in outcomes between Salto-Talaris and INBONE II. Results: The mean age of the study population was 63.5 ± 9.8 years at surgery. Mean follow-up was 4.9 ± 3.0 years. Radiographic aseptic loosening of the tibial implant showed no significant difference between the 2 groups: Salto-Talaris, 18%, and INBONE II, 18.9% ( P = .829). Aseptic loosening of the talar implant also showed no significant difference between the 2 groups: Salto-Talaris, 1.6%, and INBONE II, 1.5% ( P = .959). No variables, including the implant type, were found to contribute to the aseptic loosening rate of either the tibia or talus. Conclusion: In our cohort, we observed no difference in radiographic implant aseptic loosening between Salto-Talaris and INBONE II systems. Level of Evidence: Level IV, retrospective case series study.
The Design of the Electronic Health Record in Type 1 Diabetes Centers: Implications for Metrics and Data Availability for a Quality Collaborative
Authors: Eng Donna , Ospelt Emma , Miyazaki Brian , McDonough Ryan , Indyk Justin A. , Wolf Risa , Lyons Sarah , Neyman Anna , Fogel Naomi R. , Basina Marina , Gallagher Mary Pat , Ebekozien Osagie , Alonso G. Todd , Jones Nana-Hawa Yayah , Lee Joyce M 
Published: November 2023

Background: Systematic and comprehensive data acquisition from the electronic health record (EHR) is critical to the quality of data used to improve patient care. We described EHR tools, workflows, and data elements that contribute to core quality metrics in the Type 1 Diabetes Exchange Quality Improvement Collaborative (T1DX-QI). Method: We conducted interviews with quality improvement (QI) representatives at 13 T1DX-QI centers about their EHR tools, clinic workflows, and data elements. Results: All centers had access to structured data tools, nine had access to patient questionnaires and two had integration with a device platform. There was significant variability in EHR tools, workflows, and data elements, thus the number of available metrics per center ranged from four to 17 at each site. Thirteen centers had information about glycemic outcomes and diabetes technology use. Seven centers had measurements of additional self-management behaviors. Centers captured patient-reported outcomes including social determinants of health (n = 9), depression (n = 11), transition to adult care (n = 7), and diabetes distress (n = 3). Various stakeholders captured data including health care professionals, educators, medical assistants, and QI coordinators. Centers that had a paired staffing model in clinic encounters distributed the burden of data capture across the health care team and was associated with a higher number of available data elements. Conclusions: The lack of standardization in EHR tools, workflows, and data elements captured resulted in variability in available metrics across centers. Further work is needed to support measurement and subsequent improvement in quality of care for individuals with type 1 diabetes.
A Cross-Sectional Factor Analysis of COVID-19 and Influenza Vaccination Decisions in a Racially Diverse Western Pennsylvania Community
Authors: Sojati Jorna , Murali Anjana , Pressimone Catherine , Dakroub Allie 
Published: November 2023

Introduction: Influenza and COVID-19 vaccination rates remain suboptimal, demanding new community-centric approaches that improve targeted counseling and increase vaccine uptake. Notably, racially diverse communities show high vaccine hesitancy, yet most existing vaccine studies focus on white, college-educated cohorts. Objective: Here, we identify factors influencing vaccination decisions of patients at Turtle Creek Primary Care clinic in Turtle Creek, PA, a racially-diverse borough. Design: A retrospective mixed-methods study of the predominantly non-white patient population at Turtle Creek Primary Care clinic, a clinic caring for >70% minority patients. Results: Fourteen factors emerged that patients reported were crucial to vaccine decision-making. Of these factors, top reasons for COVID-19 vaccine hesitancy were trust in vaccines, vaccine side effects, perceived vaccine knowledge, and faith/religion. Top reasons for influenza vaccine hesitancy were perceived need, vaccine side effects, trust in vaccines, and habitual behaviors. We also uncovered correlations between vaccine decision factors and sociodemographic factors. Participants > 65-years-old were more likely to cite personal safety in choosing to get the COVID-19 vaccine, while non-white participants were more likely to cite others’ safety. Participants > 65-years-old were also more likely to cite personal safety in influenza vaccine decision-making, and non-female participants were more likely to cite perceived need for influenza vaccines. Conclusions: These data uncover targetable factors contributing to vaccine hesitancy and aid in developing community-centered, personalized vaccine education approaches in Turtle Creek and analogous minority communities.
Effect of Injury to the Lateral Meniscotibial Ligament and Meniscofibular Ligament on Meniscal Extrusion: Biomechanical Evaluation of the Capsulodesis and Centralization Techniques in a Porcine Knee Model
Authors: Morales-Avalos Rodolfo , Diabb-Zavala José Manuel , Mohamed-Noriega Nasser , Vilchez-Cavazos Félix , Perelli Simone , Padilla-Medina José Ramón , Torres-Gaytán Adrián Gerardo , Huesca-Pérez Héctor Adán , Erosa-Villarreal Roger Armando , Monllau Joan Carles 
Published: November 2023

Background: Previous biomechanical studies of the meniscotibial ligament have determined that it contributes to meniscal stability. An injury to it can cause the meniscus to extrude, and reconstruction of that ligament significantly reduces extrusion. Purpose: To assess the biomechanical effects of sectioning the lateral meniscotibial ligament (LMTL) and the meniscofibular ligament (MFL) with respect to the radial mobility of the lateral meniscus and to evaluate the biomechanical effects of the capsulodesis and centralization techniques. Study Design: Controlled laboratory study. Methods: The lateral meniscus of 22 porcine knees was evaluated. They were mounted on a testing apparatus to apply muscle and ground-reaction forces. The meniscus was evaluated at 30° and 60° of knee flexion using 2 markers placed on the posterior cruciate ligament and the lateral meniscus after applying an axial compression of 200 N to the knee joint. Measurements were recorded under 5 conditions: intact lateral meniscus, injury of the LMTL, subsequent injury of the MFL, the use of the open capsulodesis technique, and the reconstruction of the LMTL and the MFL with the centralization technique. Results: The distance between the 2 markers was significantly greater in the extrusion group (combined lesion of the LMTL and MFL) than in the intact or reconstruction groups (capsulodesis and centralization techniques; P < .001 in all cases). In the cases of load application, no significant differences were observed between the control group (intact meniscus) and the groups on which the reconstruction techniques were performed. There were also no differences when comparing the results obtained between both reconstruction techniques. In all settings, the distance between the 2 markers increased with the increase in the knee flexion angle. Conclusion: In a porcine model, the LMTL and the MFL participated as restrictors of the radial mobility of the lateral meniscus during loading. Their injury caused a significant increase in lateral meniscal extrusion, and the centralization and the capsulodesis procedures were able to reduce extrusion. Clinical Relevance: This study demonstrates the capacity of the LMTL and the MFL to restrict the radial mobility of the lateral meniscus during loading and how it is affected when they are injured.
The Effect of Pass/Fail Exam Grading on Exam Performance in a Pediatric Clerkship
Authors: Kahle Madison E , Hamann Kayla M , Sakher Aliya A , Goble Spencer R , Murray Katherine , Miller-Chang Yeng M , Olson Andrew PJ 
Published: November 2023

OBJECTIVE Clerkship grades are a component of determining a residency candidate's competitiveness. In 2017, the University of Minnesota Medical School's pediatric clerkship transitioned its standardized multiple-choice exam, the Aquifer Pediatrics Examination, to pass/fail with eligibility for honors being determined by clinical performance, not exam performance. We assessed the effect this change had on Aquifer exam performance and evaluated for correlation between Aquifer exam performance and clinical evaluation scores in order to gather insight into the validity of each type of assessment with respect to one another. METHODS We analyzed de-identified data from 750 medical students between the academic years of 2016 to 2017 and 2019 to 2020. Individual Aquifer exam scores were compared to individual clinical performance scores. Differences in exam performance before and after the transition to pass/fail were investigated with a two-sample t-test and Cohen's d for effect size. RESULTS No correlation was found between Aquifer exam scores and clinical performance scores. The mean Aquifer exam score prior to the transition to pass/fail was 80.02 ± 7.51 while the mean after the exam was made pass/fail was 77.8 ± 7.42. This difference was statistically significant ( P < .001) with a Cohen's d (effect size) of 0.297. CONCLUSIONS A lack of correlation between the Aquifer exam scores and clinical performance scores was found. There was a small yet statistically significant decrease in Aquifer exam scores after the change to pass/fail; it is not clear if this represents a meaningful decrease in learning by students.
An Exploration of the Psycho-sexual Aspects of the Motivation to Avoid Success and its Association with Gender Roles and Work-Family Conflict Using a Mixed Method
Authors: Moulik Shovona Bhattacharya , Ray Deepshikha 
Published: November 2023

Aims: The current study attempted to explore how gender roles and work-family conflict contribute to fear of success in urban, married, middle-aged, and working women. Materials and Methods: A mixed method was used in which “gender role,” “work family conflict,” and “fear of success” were measured using the Indian Gender Role Identity Scale, 1 the Work Family Conflict Scale (Carlson et al.), 2 and the Fear of Success Scale (Canavan-Gumpert et.al.), 3 respectively, followed by an interview of 10 voluntary participants for a period of 30 min each. Analysis: A stepwise multiple regression analysis of work-family conflict and gender roles on fear of success was computed as part of the quantitative analysis of the data. Open codes and focus codes were computed as part of the qualitative analysis of the data. Results and Conclusion: The results of quantitative data analysis revealed that both dimensions of “work-family conflict,” i.e., “time-based work to family” and “time based family to work,” are significant predictors of “fear of success” and that there is a significant negative correlation between “masculinity” and “fear of success.” The analysis of qualitative data revealed that the majority of the participants have talked about unpleasant consequences related to success in or being engaged in a formal job. The findings have been discussed in the context of the internalization of societal expectations and implicit coercions in urban, middle-aged, and married working women.
A Service Evaluation of Telesonography® and the Measured Outcomes, Within an Under-Resourced Obstetrics and Gynecology Practice
Authors: Manley Erin , Buentipo Ben , Blair Amber , Dilly Alison , Switzky Andy 
Published: November 2023

Objective: To evaluate the effectiveness of a tech-enabled telesonography service in an under-resourced obstetrics and gynecology (OB/Gyn) clinic. Materials and Methods: Quantitative data were collected for each sonographic exam to determine its efficiency and accuracy. A survey was also offered to measure patient satisfaction. Data were collected and analyzed to produce early trends following the implementation of the service. Results: The tech-enabled telesonography service decreased patient exam and report turnaround times in an under-resourced OB/Gyn clinic, which correlated with decreases in the time until the next appointment and the clearing of scheduling backlogs. Importantly, this efficiency was achieved without forfeiting diagnostic accuracy or patient satisfaction. Conclusion: This project demonstrated that the service provided reduced wait times for this under-resourced clinic without sacrificing diagnostic accuracy.
Safety, feasibility and effectiveness of the remotely delivered Pulmonary Hypertension and Home-Based (PHAHB) physical activity intervention
Authors: McCormack Ciara , Kehoe Brona , Cullivan Sarah , McCaffrey Noel , Gaine Sean , McCullagh Brian , McCarren Andrew , Hardcastle Sarah J. , Moyna Niall M. 
Published: November 2023

BackgroundPulmonary hypertension (PH) is a heterogeneous condition, associated with a high symptom burden and a substantial loss of exercise capacity. Despite prior safety concerns regarding physical exertion, exercise training as a supportive therapy is now recommended for PH patients. Currently, most programmes are hospital-based, which limits accessibility. There is a need to provide alternative approaches for physical activity engagement for PH patients. The aim of this research was to develop, implement and evaluate the safety, feasibility and effectiveness of home-based physical activity intervention for PH.MethodsAn entirely remotely delivered home-based physical activity intervention underpinned by behaviour change theory and informed by end-users, was assessed using a single-arm feasibility study design. Participants (n=19; 80% female) with a mean±sdage of 49.9±15.9 years with a diagnosis of PH undertook a 10-week, home-based physical activity intervention with induction training, support materials, telecommunication support, health coaching, exercise training and assessments, all remotely delivered. Training involved respiratory training along with a combination of aerobic and resistance exercises.ResultsThe intervention was deemed safe as no adverse events were reported. A high level of feasibility was demonstrated as the protocol was implemented as intended, sustained a high level of engagement and adherence and was well accepted by participants in terms of enjoyment and utility. There was a significant improvement in functional capacity, physical activity, exercise self-efficacy and quality of life, between baseline and post-training.ConclusionThe study demonstrates that an entirely remotely delivered home-based physical activity programme is safe, feasible and effective in improving functional capacity, physical activity and quality of life in PH patients.
Two is better than one: the double diffusion technique in classifying heart failure
Authors: Zavorsky Gerald S. , Agostoni Piergiuseppe 
Published: November 2023

BackgroundHeart failure (HF) is a chronic condition in which the heart does not pump enough blood to meet the body's demands. Diffusing capacity of the lung for nitric oxide (DLNO) and carbon monoxide (DLCO) may be used to classify patients with HF, asDLNOandDLCOare lung function measurements that reflect pulmonary gas exchange. Our objectives were to determine 1) ifDLNOadded toDLCOtesting predicts HF better thanDLCOalone and 2) whether the binary classification of HF is better whenDLNOz-scores are combined withDLCOz-scores than usingDLCOz-scores alone.MethodsThis was a retrospective secondary data analysis in 140 New York Heart Association Class II HF patients (ejection fraction <40%) and 50 patients without HF. z-scores forDLNO,DLCOandDLNO+DLCOwere created from reference equations from three articles. The model with the lowest Bayesian Information Criterion was the best predictive model. Binary HF classification was evaluated with the Matthews Correlation Coefficient (MCC).ResultsThe top two of 12 models were combined z-score models. The highest MCC (0.51) was from combined z-score models. At most, only 32% of the variance in the odds of having HF was explained by combined z-scores.ConclusionsCombined z-scores explained 32% of the variation in the likelihood of an individual having HF, which was higher than models usingDLNOorDLCOz-scores alone. Combined z-score models had a moderate ability to classify patients with HF. We recommend using the NO–CO double diffusion technique to assess gas exchange impairment in those suspected of HF.
CD44-specific short peptide A6 boosts cellular uptake and anticancer efficacy of PEGylated liposomal doxorubicin in vitro and in vivo
Authors: Yazdian-Robati Rezvan , Amiri Ehsan , Kamali Hossein , Khosravi Aysun , Taghdisi Seyed Mohammad , Jaafari Mahmoud Reza , Mashreghi Mohammad , Moosavian Seyedeh Alia 
Published: November 2023

AbstractAlthough liposomes have improved patient safety and the pharmacokinetic profile of free drugs, their therapeutic efficacy has only shown marginal improvement. The incorporation of active-targeted ligands to enhance cellular uptake has shown promise in preclinical studies. However, no active-targeted liposomes have successfully translated into clinical use thus far. This study aimed to evaluate the targeting ability and antitumor efficiency of A6, a specific short peptide (KPSSPPEE) when incorporated into PEGylated liposomal doxorubicin (PLD). The results revealed significantly enhanced cellular uptake. The cytotoxicity of the formulations was determined by 3 h and 6 h incubation of formulations with cells, followed by 48 h incubation to evaluate the targeted ability of the formulations and the results indicated the higher cytotoxicity of A6-PLD (IC50 of 7.52 µg/mL after 6 h incubation) in the CD44 overexpressing C26 cell line compared to non-targeted PLD (IC50 of 15.02 µg/mL after 6 h incubation). However, CD44-negative NIH-3T3 cells exhibited similar uptake and in vitro cytotoxicity for both A6-PLD (IC50 of 38.05 µg/mL) and PLD (IC50 of 34.87 µg/mL). In animal studies, A6-PLD demonstrated significantly higher tumor localization of doxorubicin (Dox) (~ 8 and 15 µg Dox/g tumor for 24 and 48 after injection) compared to PLD (~ 6 and 8 µg Dox/g tumor for 24 and 48 after injection), resulting in effective inhibition of tumor growth. The median survival time (MST) for Dextrose 5% was 10, PLD was 14 and A6-PLD was 22 days. In conclusion, A6-PLD, a simple and effective targeted liposome formulation, exhibits high potential for clinical translation. Its improved targetability and antitumor efficacy make it a promising candidate for future clinical applications.
Heterogeneity in convergence behaviour of the single-step SNP-BLUP model across different effects and animal groups
Authors: Słomian Dawid , Żukowski Kacper , Szyda Joanna 
Published: November 2023

Abstract
Background
The single-step model is becoming increasingly popular for national genetic evaluations of dairy cattle due to the benefits that it offers such as joint breeding value estimation for genotyped and ungenotyped animals. However, the complexity of the model due to a large number of correlated effects can lead to significant computational challenges, especially in terms of accuracy and efficiency of the preconditioned conjugate gradient method used for the estimation. The aim of this study was to investigate the effect of pedigree depth on the model's overall convergence rate as well as on the convergence of different components of the model, in the context of the single-step single nucleotide polymorphism best linear unbiased prediction (SNP-BLUP) model.

Results
The results demonstrate that the dataset with a truncated pedigree converged twice as fast as the full dataset. Still, both datasets showed very high Pearson correlations between predicted breeding values. In addition, by comparing the top 50 bulls between the two datasets we found a high correlation between their rankings. We also analysed the specific convergence patterns underlying different animal groups and model effects, which revealed heterogeneity in convergence behaviour. Effects of SNPs converged the fastest while those of genetic groups converged the slowest, which reflects the difference in information content available in the dataset for those effects. Pre-selection criteria for the SNP set based on minor allele frequency had no impact on either the rate or pattern of their convergence. Among different groups of individuals, genotyped animals with phenotype data converged the fastest, while non-genotyped animals without own records required the largest number of iterations.

Conclusions
We conclude that pedigree structure markedly impacts the convergence rate of the optimisation which is more efficient for the truncated than for the full dataset.
CoDock-Ligand: combined template-based docking and CNN-based scoring in ligand binding prediction
Authors: Pang Mingwei , He Wangqiu , Lu Xufeng , She Yuting , Xie Liangxu , Kong Ren , Chang Shan 
Published: November 2023

AbstractFor ligand binding prediction, it is crucial for molecular docking programs to integrate template-based modeling with a precise scoring function. Here, we proposed the CoDock-Ligand docking method that combines template-based modeling and the GNINA scoring function, a Convolutional Neural Network-based scoring function, for the ligand binding prediction in CASP15. Among the 21 targets, we obtained successful predictions in top 5 submissions for 14 targets and partially successful predictions for 4 targets. In particular, for the most complicated target, H1114, which contains 56 metal cofactors and small molecules, our docking method successfully predicted the binding of most ligands. Analysis of the failed systems showed that the predicted receptor protein presented conformational changes in the backbone and side chains of the binding site residues, which may cause large structural deviations in the ligand binding prediction. In summary, our hybrid docking scheme was efficiently adapted to the ligand binding prediction challenges in CASP15.