bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfectionism in anorexia nervosa: Associations with clinical picture and personality traits
Authors: Longo Paola , Bevione Francesco , Amodeo Laura , Martini Matteo , Panero Matteo , Abbate‐Daga Giovanni 
Published: November 2023

AbstractAlthough many researchers addressed the topics, no consistent data are currently available regarding the relationship between perfectionism and personality traits in anorexia nervosa (AN). The present study aimed to assess differences between high‐ and low‐perfectionism groups of patients with AN and to identify which variables show the strongest association with perfectionism. A group of inpatients with AN (n = 193) was recruited and completed a battery of self‐report questionnaires regarding eating‐related and general psychopathology, perfectionism, and personality. On the basis of perfectionism scores, patients were divided into high‐ and low‐perfectionism groups. High‐perfectionist patients displayed higher eating‐related and general psychopathology; higher depressive, cyclothymic, irritable and anxious temperament, and lower self‐directedness, cooperativeness and self‐esteem. Perfectionism was associated with the drive for thinness, cooperativeness, self‐esteem and anxious temperament. On the basis of the two personality traits most strongly correlated with perfectionism (i.e., cooperativeness and anxious temperament), patients could be correctly assigned to the high‐ or low‐perfectionism group by an algorithm. The study suggests that perfectionism in AN is related to eating psychopathology, especially of restrictive type, and personality features such as cooperativeness and anxious temperament. These findings confirm the important role of perfectionism in AN, not only concerning eating behaviour but personality as well.
A novel LCC‐C(CL)2 compensation network for efficient magnetically coupled resonant wireless power transfer for EV charging
Authors: Li Zhizhong , Zhang Haonan , Zhang Guidong , Yu Shenglong , Zhang Yichi , Long Shuqun 
Published: November 2023

AbstractDue to the intrinsic limitations, for example, limited adjustment freedom, the traditional wireless power transfer (WPT) systems cannot maintain high efficiency under variable loading conditions. To well solve this problem, a family of general magnetically coupled resonant WPT (MCR‐WPT) compensation topologies composed of LCC‐C with an
‐stage LC structure, or LCC‐C(CL)
, is proposed in this paper. Under the guideline of the generalized structure, some existing topologies are derived for verification, with new topologies established with unique advantages. From the LCC‐C(CL)
structures, a suitable topology can be selected to achieve a desired design purpose, such as constant voltage transmission, constant current transmission, or high‐efficiency transmission. Prototype experiments and comparisons are conducted in this work, which demonstrate the effectiveness and applicability of the proposed LCC‐C(CL)
MCR‐WPT converter family and the parameter design method. Experimental results also show that the new topology can maintain high‐efficiency power transfer for a wide range of loads. Even under light loading conditions, the power transfer efficiency is 30% higher than the traditional benchmark topology. The proposed WPT approach will have wide applications for on‐road wireless electric vehicle charging.
Assessment of inter‐operator variability in peripheral monocyte subset gating strategy using flow cytometry in patients with suspected acute stroke
Authors: Heng Evelyne , Neuwirth Marie , Mas Floriane , Contant Geneviève , Mazighi Mikaël , Feriel Joffrey , Montpellier Bertrand , Brumpt Caren , Jourdi Georges , Curis Emmanuel , Siguret Virginie 
Published: November 2023

AbstractBackgroundInnovative tools to reliably identify patients with acute stroke are needed. Peripheral monocyte subsets, that is, classical‐Mon1, intermediate‐Mon2, and non‐classical‐Mon3, with their activation marker expression analyzed using flow‐cytometry (FCM) could be interesting cell biomarker candidates.AimTo assess the inter‐operator variability in a new peripheral monocyte subset gating strategy using FCM in patients with suspected acute stroke.MethodsIn BOOST‐study (“Biomarkers‐algOrithm‐for‐strOke‐diagnoSis‐and Treatment‐resistance‐prediction,” NCT04726839), patients ≥18 years with symptoms suggesting acute stroke within the last 24 h were included. Blood was collected upon admission to emergency unit. FCM analysis was performed using the FACS‐CANTO‐II® flow‐cytometer and Flow‐Jo™‐software. Analyzed markers were CD45/CD91/CD14/CD16 (monocyte backbone) and CD62L/CD11b/HLA‐DR/CD86/CCR2/ICAM‐1/CX3CR1/TF (activation markers). Inter‐operator agreement (starting from raw‐data files) was quantified by the measure distribution and, for each patient, the coefficient of variation (CV).ResultsThree operators analyzed 20 patient blood samples. Median inter‐operator CVs were below the pre‐specified tolerance limits (10% [for Mon1 counts], 20% [Mon2, Mon3 counts], 15% [activation marker median‐fluorescence‐intensities]). We observed a slight, but systematic, inter‐operator effect. Overall, absolute inter‐operator differences in fractions of monocyte subsets were <0.03.ConclusionOur gating strategy allowed monocyte subset gating with an acceptable inter‐operator variability. Although low, the inter‐operator effect should be considered in monocyte data analysis of BOOST‐patients.
Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential
Authors: Hamley Madeleine , Leyk Stephanie , Casar Christian , Liebold Imke , Jawazneh Amirah Al , Lanzloth Clarissa , Böttcher Marius , Haas Helmut , Richardt Ulricke , Rothlin Carla V. , Jacobs Thomas , Huber Samuel , Adlung Lorenz , Pelczar Penelope , Henao‐Mejia Jorge , Bosurgi Lidia 
Published: November 2023

AbstractThe initiation of tissue remodeling following damage is a critical step in preventing the development of immune‐mediated diseases. Several factors contribute to mucosal healing, leading to innovative therapeutic approaches for managing intestinal disorders. However, uncovering alternative targets and gaining mechanistic insights are imperative to enhance therapy efficacy and broaden its applicability across different intestinal diseases.Here we demonstrate that Nmes1, encoding for Normal Mucosa of Esophagus‐Specific gene 1, also known as Aa467197, is a novel regulator of mucosal healing. Nmes1 influences the macrophage response to the tissue remodeling cytokine IL‐4 in vitro. In addition, using two murine models of intestinal damage, each characterized by a type 2‐dominated environment with contrasting functions, the ablation of Nmes1 results in decreased intestinal regeneration during the recovery phase of colitis, while enhancing parasitic egg clearance and reducing fibrosis during the advanced stages of Schistosoma mansoni infection. These outcomes are associated with alterations in CX3CR1+ macrophages, cells known for their wound‐healing potential in the inflamed colon, hence promising candidates for cell therapies.All in all, our data indicate Nmes1 as a novel contributor to mucosal healing, setting the basis for further investigation into its potential as a new target for the treatment of colon‐associated inflammation.
Organocatalytic Synthesis of 2,3,4,9‐Tetrahydro‐1H‐carbazole Embedded Styrene Atropisomers
Authors: Parida Chandrakanta , Devi Minakshi , Chandra Pan Subhas 
Published: November 2023

AbstractHerein we report the first synthesis of tetrahydrocarbazole embedded styrene atropisomers via the reaction between 1‐(aryl‐ethynyl)‐naphthalen‐2‐ol and 2,3,4,9‐tetrahydro‐1H‐carbazole. The reaction proceeds through in situ vinylidene ortho‐quinone methide (VQM) intermediate formation. The styrene derivatives were obtained in good to high yields with high diastereoselectivities with a catalytic amount of PTSA. A catalytic asymmetric version is also reported.
Stereo‐electroencephalography‐guided three‐dimensional radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis: A retrospective study with long‐term follow‐up
Authors: Li Kaiwei , Shi Jianwei , Wei Penghu , He Xiaosong , Shan Yongzhi , Zhao Guoguang 
Published: November 2023

AbstractObjectiveStereo‐electroencephalography‐guided three‐dimensional radiofrequency thermocoagulation (SEEG‐3D RFTC) is a minimally invasive treatment for mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS). This study aimed to investigate the long‐term prognosis after SEEG‐3D RFTC treatment in patients with MTLE‐HS.MethodsThis single‐center retrospective study included 28 patients with MTLE‐HS treated with SEEG‐3D RFTC from January 2016 to May 2018. Postoperative curative effects were evaluated using the Engel classification, and the patients were followed up for 5 years.ResultsThe proportions of patients categorized as Engel I between 1 and 5 years after surgery were 72.41% (12 months after surgery), 67.86% (18 months after surgery), 62.07% (24 months after surgery), 50.00% (36 months after surgery), 42.86% (48 months after surgery), and 42.86% (60 months after surgery), respectively. Regarding long‐term efficacy, based on the Engel classification, SEEG‐3D RFTC showed room for improvement.SignificanceThis was the first study to evaluate the efficacy of SEEG‐3D RFTC for MTLE‐HS with long‐term follow‐up. SEEG‐3D RFTC is a promising alternative for patients with MTLE‐HS.Plain Language SummaryThis study explored the potential of stereoelectroencephalography‐guided three‐dimensional radiofrequency thermocoagulation, a minimally invasive approach, for treating medial temporal lobe epilepsy with hippocampal sclerosis. Involving 28 patients, the research tracked the treatment’s success over five years using the Engel classification. Initial results were promising, with 72.41% of patients achieving the most favorable outcome (Engel I) at one year. While there was a gradual decrease in this proportion over time, 42.86% of patients maintained this positive outcome at five years, highlighting the treatment's potential for long‐term efficacy.
Derivation of generalized thermoelectric energy equations and the study of thermoelectric irreversible processes based on energy, exergy, and entransy analysis
Authors: Xiao Heng 
Published: November 2023

AbstractThermoelectric (TE) generation is becoming a valuable and promising research direction. Many researchers have carried out system analysis and performance optimization of thermoelectric technologies based on the generalized thermoelectric energy balance equations. However, it is assumed that TE legs have no heat exchange with the ambient except at the junctions of the hot and cold ends where heat flows in and out. Based on basic thermoelectric effects and fundamental theories of heat transfer, a detailed derivation of the revised generalized thermoelectric energy equations considering convective heat transfer between TE legs and the ambient has been carried out. Irreversible heat transfer processes have been analyzed by employing energy analysis based on the first law of thermodynamics and exergy analysis based on the second law of thermodynamics. The results show that convective heat transfer leads to a decrease in both energy and exergy efficiencies: the rate and magnitude of the decrease in exergy efficiency are greater than those of the decrease in energy efficiency. The exergy efficiency is relatively high despite the low energy efficiency in operation, revealing the features and advantages of thermoelectric generators (TEGs) in low‐grade energy utilization. For TEG efficient operation, the load resistance value should match the system's internal resistance, or at least be greater than that, to avoid a sharp drop in power output and efficiencies. In an attempt at theoretical analysis, the concept of entransy was first introduced into thermoelectric analysis, yielding two concise relational equations which reflect the intrinsic link between Carnot cycle efficiency, energy efficiency, exergy efficiency, and entransy flow transfer efficiency. The entransy analysis based on the index of entransy flow transfer efficiency, together with energy analysis and exergy analysis, may be a novel and valuable guideline for the operation and optimization of TEGs, which needs to be further investigated.
Bias and mean squared error in Mendelian randomization with invalid instrumental variables
Authors: Deng Lu , Fu Sheng , Yu Kai 
Published: November 2023

AbstractMendelian randomization (MR) is a statistical method that utilizes genetic variants as instrumental variables (IVs) to investigate causal relationships between risk factors and outcomes. Although MR has gained popularity in recent years due to its ability to analyze summary statistics from genome‐wide association studies (GWAS), it requires a substantial number of single nucleotide polymorphisms (SNPs) as IVs to ensure sufficient power for detecting causal effects. Unfortunately, the complex genetic heritability of many traits can lead to the use of invalid IVs that affect both the risk factor and the outcome directly or through an unobserved confounder. This can result in biased and imprecise estimates, as reflected by a larger mean squared error (MSE). In this study, we focus on the widely used two‐stage least squares (2SLS) method and derive formulas for its bias and MSE when estimating causal effects using invalid IVs. Using those formulas, we identify conditions under which the 2SLS estimate is unbiased and reveal how the independent or correlated pleiotropic effects influence the accuracy and precision of the 2SLS estimate. We validate these formulas through extensive simulation studies and demonstrate the application of those formulas in an MR study to evaluate the causal effect of the waist‐to‐hip ratio on various sleeping patterns. Our results can aid in designing future MR studies and serve as benchmarks for assessing more sophisticated MR methods.
The effects of low calorie, high protein diet on body composition, duration and sleep quality on obese adults: A randomized clinical trial
Authors: Javaheri Fatemeh Sadat Hashemi , Ostadrahimi A. R. , Nematy Mohsen , Arabi Seyyed Mostafa , Amini Mahnaz 
Published: November 2023

AbstractBackground and AimsThe effects of high‐protein diets on regulating sleep have received research attention in recent decades. However, no studies have examined the effects of these diets in obese adults. Therefore, this study was conducted to investigate the effects of low‐calorie high protein diets on sleep quality in obese adults.MethodsThis study is a randomized clinical trial conducted on 60 obese adults (BMI > 29.9 kg/m2) diagnosed with low‐quality sleep. All participants were given a diet with a 750‐calorie energy deficit. While the control group was given a normal diet, the intervention group received a diet with 30% more protein.ResultsThe results showed a significant difference between the control group and intervention group with respect to sleep apnea at 30‐, 60‐, and 90‐day follow‐up (p < 0.01). Sleep quality, apnea‐hypopnea index (AHI), sleep latency (SL), and polysomnography were significantly different between the two groups (p < 0.05), showing an improvement in sleep quality and obstructive sleep apnea in the intervention group (p < 0.05).ConclusionThis study shows that low‐calorie high‐protein diets can effectively improve apnea, sleep quality, and body composition indices in obese adults.
Seroconversion after SARS‐CoV‐2 vaccination is protective against severe COVID‐19 disease in heart transplant recipients
Authors: Kugler Szilvia , Vári Dorottya Katalin , Veres Dániel Sándor , Király Ákos , Teszák Tímea , Parázs Nóra , Tarjányi Zoltán , Drobni Zsófia , Szakál‐Tóth Zsófia , Prinz Gyula , Miheller Pál , Merkely Béla , Sax Balázs 
Published: November 2023

AbstractBackgroundHeart transplant (HTX) recipients are prone to develop complications after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Vaccination is often ineffective due to weaker immunogenicity. In this high‐volume single‐center study, we aimed to determine factors influencing seroconversion after vaccination and predictors of severe SARS‐CoV‐2 infection.MethodsTwo hundred twenty‐nine HTX recipients were enrolled. Type of the first two vaccine doses included messenger RNA (mRNA), vector, and inactivated vaccines. We carried out analyses on seroconversion after the second and third doses of vaccination and on severity of infection. Antispike protein SARS‐CoV‐2 immunoglobulin G (IgG) was measured after the second and third vaccines and serostatus was defined. Effect of the first two vaccine doses was studied on patients who did not suffer SARS‐CoV‐2 infection before antibody measurement (n = 175). The effectivity of the third vaccine was evaluated among seronegative recipients after the second vaccine (n = 53). Predictors for severe infection defined as pneumonia, hospitalization or death were assessed in all patients who contracted SARS‐CoV‐2 infection (n = 92).Results62% of the recipients became seropositive after the second vaccination. Longer time between HTX and vaccination (odds ratio [OR]: 2.35) and mRNA vaccine (OR: 4.83) were predictors of seroconversion. 58% of the nonresponsive patients became seropositive after receiving the third vaccine. Male sex increased the chance of IgG production after the third dose (OR: 5.65). Clinical course of SARS‐CoV‐2 infection was severe in 32%. Of all parameters assessed, only seropositivity before infection was proven to have a protective effect against severe infection (OR: 0.11).ConclusionsWe found that longer time since HTX, mRNA vaccine type, and male sex promoted seroconversion after SARS‐CoV‐2 vaccination in HTX recipients. Seropositivity—but not the number of vaccine doses—seemed to be protective against severe SARS‐CoV‐2 infection. Screening of HTX patients for anti‐SARS‐COV‐2 antibodies may help to identify patients at risk for severe infection.
Close‐packed layer spacing as a practical guideline for structure symmetry manipulation of IV‐VI/I‐V‐VI2 thermoelectrics
Authors: Jin Tao , Yang Long , Zhang Xinyue , Li Wen , Pei Yanzhong 
Published: November 2023

AbstractThe crystal‐structure symmetry in real space can be inherited in the reciprocal space, making high‐symmetry materials the top candidates for thermoelectrics due to their potential for significant electronic band degeneracy. A practical indicator that can quantitatively describe structural changes would help facilitate the advanced thermoelectric material design. In face‐centered cubic structures, the spatial environment of the same crystallographic plane family is isotropic, such that the distances between the close‐packed layers can be derived from the atomic distances within the layers. Inspired by this, the relationship between inter‐ and intra‐layer geometric information can be used to compare crystal structures with their desired cubic symmetry. The close‐packed layer spacing was found to be a practical guideline of crystal structure symmetry in IV‐VI chalcogenides and I‐V‐VI2 ternary semiconductors, both of which are historically important thermoelectrics. The continuous structural evolution toward high symmetry can be described by the layer spacing when temperature or/and composition change, which is demonstrated by a series of pristine and alloyed thermoelectric materials in this work. The layer‐spacing‐based guideline provides a quantitative pathway for manipulating crystal structures to improve the electrical and thermal properties of thermoelectric materials.
Cryptic exon activation caused by a novel deep‐intronic splice‐altering variant in Becker muscular dystrophy
Authors: Xie Zhiying , Lu Yunlong , Liu Chang , Sun Chengyue , Yu Jiaxi , Ling Chen , Luan Xinghua , Wang Wei , Wang Li , Liang Yanhong , Luo Qianbo , Meng Lingchao , Wang Zhaoxia , Yuan Yun 
Published: November 2023

AbstractBackgroundAn accurate genetic diagnosis of Becker muscular dystrophy (BMD) can be sometimes challenging due to deep intronic DMD variants. Here, we report on the genetic diagnosis of a BMD patient with a novel deep‐intronic splice‐altering variant in DMD.MethodsThe index case was a 3.8‐year‐old boy who was suspected of having a diagnosis of BMD based on his clinical, muscle imaging, and pathological features. Routine genomic detection approaches did not detect any disease‐causing variants in him. Muscle‐derived DMD mRNA studies, followed by genomic Sanger sequencing and in silico bioinformatic analyses, were performed in the patient.ResultsDMD mRNA studies detected a cryptic exon‐containing transcript and normally spliced DMD transcript in the patient. The cryptic exon‐containing transcript encoded a frameshift and premature termination codon (NP_003997.1:p.[=,Asp2740Valfs*52]). Further genomic Sanger sequencing and bioinformatic analysis identified a novel deep‐intronic splice‐altering variant in DMD (c.8217 + 23338A > G). The novel variant strengthened a cryptic donor splice site and activated a cryptic acceptor splice site in the deep‐intronic region of DMD intron 55, resulting in the activation of a new dystrophin cryptic exon found in the patient.ConclusionOur case report expands the genetic spectrum of BMD and highlights the essential role of deep‐intronic cryptic exon‐activating variants in genetically unsolved BMD patients.