bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Outcomes of Facial Reanimation Between the Use of Cross-facial Nerve Graft and the Masseteric Nerve as the Donor Nerve for Reinnervation of Gracilis Muscle Flap Transfer
Authors: Liang Hongyu , Yang Zhe , Ma Ning , Wang Weixin , Li Yangqun 
Published: December 2023

Background:
In patients with facial paralysis, the free functional gracilis muscle transfer is preferred for facial reanimation. The choice of an adequate motor nerve to innervate the transplanted gracilis muscle is one of the procedure’s key components. We present a comparative study between cross-facial nerve graft (CFNG) and masseteric nerve as donor nerves for reinnervated gracilis flap transfer in patients with complete facial paralysis.

Materlals and Methods:
Retrospective analysis was performed on all patients with complete facial paralysis who had a free functional gracilis muscle transfer for facial reanimation between January 2014 and December 2021. Only those who received gracilis transfer reinnervated by either CFNG or masseteric nerve were included in this study. The smile excursion and lip angle were measured for evaluating the outcomes postoperatively.

Results:
The inclusion criteria were met by a total of 21 free functional gracilis muscle transfers, of which 11 were innervated by CFNG and 10 by the masseteric nerve. Both surgical procedures resulted in a highly considerable smile excursion of the reanimated side and postoperative improvement of static or dynamic lip angle. Masseteric nerve coaptation led to greater smile excursion and more significant improvement of dynamic lip angle than CFNG.

Conclusions:
For patients who have complete facial paralysis, face reanimation can be successfully accomplished by free gracilis transfer reinnervated by the CFNG or the masseteric nerve. In particular, the masseteric nerve is a reliable choice for dynamic smile reanimation.
Customized Reconstruction of Lower Eyelid Defects
Authors: Kwon Hyeokjae , Song Bokeun , Ha Yooseok , Kim Sunje , Oh Sang-Ha , Seo Young-Joon , Song Seung Han 
Published: December 2023

Background:
A lower eyelid defect is a loss of skin, muscle, and underlying structures that can occur due to trauma, malignant or benign tumors, burns, or other causes. The conventional surgical treatment of lower lid defects has several limitations, including visible scarring, narrowing of the eye, and ectropion. Here, we combined the use of a customized mid-face lift with a free mucochondral graft to overcome the disadvantages of existing methods.

Methods:
Forty patients underwent reconstructive surgery using a customized mid-face lift with or without a free mucochondral graft for a lower lid defect between April 2013 and October 2020. Patients were discharged shortly after surgery and were expected to visit the outpatient clinic periodically for 12 months.

Results:
The causes of lower eyelid defects were malignancy, trauma, foreign body granuloma, and other causes. Four patients reported complications, including 2 cases of chemosis, 1 case of a hematoma, and 1 case of corneal abrasion, who reportedly performed well after 2 weeks of conservative therapy. No patient required revision during the average follow-up period.

Conclusions:
Customized reconstruction demonstrated a better aesthetic reconstruction of the lower eyelid. This method represents a good option for reconstructing lower lid defects.
The accuracy of polygenic score models for anthropometric traits and Type II Diabetes in the Native Hawaiian Population
Authors: Lo Ying-Chu , Chan Tsz Fung , Jeon Soyoung , Maskarinec Gertraud , Taparra Kekoa , Nakatsuka Nathan , Yu Mingrui , Chen Chia-Yen , Lin Yen-Feng , Wilkens Lynne R. , Le Marchand Loic , Haiman Christopher A. , Chiang Charleston W.K. 
Published: December 2023

AbstractPolygenic scores (PGS) are promising in stratifying individuals based on the genetic susceptibility to complex diseases or traits. However, the accuracy of PGS models, typically trained in European- or East Asian-ancestry populations, tend to perform poorly in other ethnic minority populations, and their accuracies have not been evaluated for Native Hawaiians. Using body mass index, height, and type-2 diabetes as examples of highly polygenic traits, we evaluated the prediction accuracies of PGS models in a large Native Hawaiian sample from the Multiethnic Cohort with up to 5,300 individuals. We evaluated both publicly available PGS models or genome-wide PGS models trained in this study using the largest available GWAS. We found evidence of lowered prediction accuracies for the PGS models in some cases, particularly for height. We also found that using the Native Hawaiian samples as an optimization cohort during training did not consistently improve PGS performance. Moreover, even the best performing PGS models among Native Hawaiians would have lowered prediction accuracy among the subset of individuals most enriched with Polynesian ancestry. Our findings indicate that factors such as admixture histories, sample size and diversity in GWAS can influence PGS performance for complex traits among Native Hawaiian samples. This study provides an initial survey of PGS performance among Native Hawaiians and exposes the current gaps and challenges associated with improving polygenic prediction models for underrepresented minority populations.
First-line chemotherapies administered before hematopoietic cell transplantation in children with acute leukemia: effect on the spermatogonial pool
Authors: Gille A.S. , Lenez L. , Vanhæsebrouck A. , Rivet-Danon D. , Lapoujade C. , Riou L. , Dalle J.H. , Yakouben K. , Peycelon M. , Fahd M. , Paye-Jaouen A. , Meyran D. , Leverger G. , Tabone M.D. , Boutroux H. , Irtan S. , Chenouf C. , Sibony M. , Chalas C. , Patrat C. , Wolf J.P. , Boissel N. , Fouchet P. , Poirot C. , Barraud-Lange V. 
Published: December 2023

AbstractApproximately 20% of pediatric patients presenting with acute leukemia (AL) receive an allogeneic hematopoietic stem cell transplantation (HSCT) either in the first or subsequent complete remission. Survivors are exposed at adulthood to fertility impairment, which is one of the most worrisome long-term side effects of pre-HSCT myeloablative conditioning regimens, while conventional chemotherapy is associated with a low risk of infertility. Thus, fertility preservation is highly recommended in young patients before HSCT. Testicular tissue cryopreservation (TTC) is the only option offered to prepubertal or peripubertal patients, with the perspective of restoring fertility from the spermatogonia contained in the immature tissue. Our study presents the largest series published to date about the testicular tissue content of spermatogonia in young patients with AL after administration of first-line chemotherapies. It shows that non-alkylating chemotherapies administered before TTC do not significantly reduce the spermatogonial pool. Our work also confirms in a large population that CCD over 4 g/m² causes sharp depletion of the spermatogonial pool. This study provides new valuable information regarding the reproductive potential of testicular tissue collected before HSCT from children with AL previously exposed to first-line chemotherapies including alkylating agent or not.
A Retroactive Study on Factors Influencing the Efficacy of Treatment for Tuberculosis Patients with HIV: based on the data from 2010 to 2020 in Shanghai, China
Authors: Dong Chenyu , Zhang Renfang , Li Shenyang , Chen Jun , Liu Yunhe , Xia Xiaoqiong , Liu Gang , Shen Yinzhong , Liu Lei , Zeng Liyan 
Published: December 2023

AbstractAt present, the factors influencing Tuberculosis (TB) treatment effectiveness in HIV/TB co-infected patients need to be supported by more substantial real-world evidence. A retrospective study is conducted to fill the vacancy. 461 TB patients with HIV are defined as 742 samples according to each TB detection period. 7788 valid treatment records corresponding to 17 drug compositions for TB and 150 clinical indicators with more than 100 records are used to conduct data mining with consensus clustering, Fisher’s exact test, stratified analysis, and three modeling approaches, including logistic regression, support vector machine, and random forest. We find that A CD4+T cell count of 42 cells per μL may serve as a sensitive classification standard for the immune level to assist in evaluating or predicting the efficacy of TB (P=0.007); Rifabutin and levofloxacin alone or in combination may be more effective than other first- and second-line anti-TB agents in combination (P=0.037); Samples with low immune levels (CD4≦42) may be more resistant to first-line TB drugs (P=0.049); Age (P=0.015), bicarbonate radical (P=0.007), high-density lipoprotein cholesterol (P=0.026), pre-treatment CD8+T cell count (P=0.015, age<60, male), neutrophil percentage (P=0.033, age<60), rifabutin (P=0.010, age<60), and cycloserine (P=0.027, age<60) may influence the TB treatment effectiveness; More evidence is needed to support the relationship between pre-treatment clinical indicators or drug regimens and TB treatment effectiveness (The best AUC is 0.560∼0.763); The percentage of lymphocytes (P=0.028) can be used as an effective TB therapeutic target. These perspectives supplement knowledge in relevant clinical aspects.
Co designing a novel game for young people who have experienced adverse childhood experiences: Protocol
Authors: Butcher Isabelle , Fazel Mina , McCrone Paul , Krzywinska Tanya , Belinskiy Anton , Smith Lindsay , Ma Minhua , Pavarini Gabriela , Sansoy Harsimran , Mankee-Williams Anna , Teasdale Ben , Bhui Kamaldeep 
Published: December 2023

AbstractBackgroundAdverse childhood experiences (ACEs) are associated with poorer mental health outcomes later in life. Research to date has focused on utilising qualitative and quantitative measures to understand possible mechanisms, and interventions for those who may have experienced ACEs.ObjectivesThis study aims to co-design a novel digital game, in collaboration with youth and adult stakeholders, to engage 12-25-year olds in learning about the impact of ACEs and how to protect and promote mental health following ACE exposure. Additionally, this project aims to evaluate the feasibility and acceptability of such an intervention.MethodsThis study will adopt Experience Based Co- Design methods with adolescents aged between 12 and 24 living in England, and will involve adult stakeholders working in the public sector. We will then evaluate the feasibility and acceptability of the co-designed game on young people, and test its cost-effectiveness.ConclusionThis project will enable an insight into the processes of co-designing a youth-informed public mental health game-based intervention and feasibility and acceptability of a serious game approach for adolescents aged between 12-24 years of age who may have experienced ACEs.Strengths and limitations of this study-Adverse childhood experiences (ACEs) are associated with poorer mental health outcomes later in life. Research to date has primarily focused on quantitative and qualitative data to explore possible resources for young people. This study describes a novel digital game study for young people who may have experienced adversities.-The data on adverse childhood experiences has primarily on focused on urban and rural areas; this study seeks to recruit young people from rural, urban and coastal regions across England-This study is restricted to England, and whilst it is hoped the findings will be applicable to the U.K and more globally, the authors acknowledge the limitations of working with young people only in England-This study is one of a few studies that has sought to involve young people through the co design of a resource for young people who may have experienced adversities from initial conception of the idea to implementation of the game.
Ultrastructural, metabolic and genetic determinants of the acquisition of macrolide resistance byStreptococcus pneumoniae
Authors: Wu Xueqing , Alibayov Babek , Xiang Xi , Lattar Santiago M. , Sakai Fuminori , Medders Austin A. , Antezana Brenda , Keller Lance , Vidal Ana G. J. , Tzeng Yih-Ling , Robinson D. Ashley , Stephens David , Yu Yunsong , Vidal Jorge E. 
Published: December 2023

AbstractAimStreptococcus pneumoniae(Spn) acquires genes for macrolide resistance, MEGA orermB, in the human host. These genes are carried either in the chromosome, or on integrative conjugative elements (ICEs). Here, we investigated molecular determinants of the acquisition of macrolide resistance.Methods and ResultsWhole genome analysis was conducted for 128 macrolide-resistant pneumococcal isolates to identify the presence of MEGA (44.5%, 57/128) orermB(100%), and recombination events in Tn916-related elements or in the locuscomCDEencoding competence genes. Confocal and electron microscopy studies demonstrated that, during the acquisition of macrolide resistance, pneumococcal strains formed clusters of varying size, with the largest aggregates having a median size of ∼1600 µm2. Remarkably, these pneumococcal aggregates comprise both encapsulated and nonencapsulated pneumococci, exhibited physical interaction, and spanned extracellular and intracellular compartments. We assessed the recombination frequency (rF) for the acquisition of macrolide resistance by a recipient D39 strain, from pneumococcal strains carrying MEGA (∼5.4 kb) in the chromone, or in large ICEs (>23 kb). Notably, the rF for the acquisition of MEGA, whether in the chromosome or carried on an ICE was similar. However, the rF adjusted to the acquisition of the full-length ICE (∼52 kb), compared to that of the capsule locus (∼23 kb) that is acquired by transformation, was three orders of magnitude higher. Finally, metabolomics studies revealed a link between the acquisition of ICE and the metabolic pathways involving nicotinic acid and sucrose.ConclusionsExtracellular and intracellular pneumococcal clusters facilitate the acquisition of full-length ICE at a rF higher than that of typical transformation events, involving distinct metabolic changes that present potential targets for interventions.
Psychometric validation and clinical correlates of an experiential foraging task
Authors: McInnes Aaron N. , Sullivan Christi R. P. , MacDonald Angus W. , Widge Alik S. 
Published: December 2023

AbstractMeasuring the function of decision-making systems is a central goal of computational psychiatry. Individual measures of decisional function could be used to describe neurocognitive profiles that underpin psychopathology and offer insights into deficits that are shared across traditional diagnostic classes. However, there are few demonstrably reliable and mechanistically relevant metrics of decision making that can accurately capture the complex overlapping domains of cognition whilst also quantifying the heterogeneity of function between individuals. The WebSurf task is a reverse-translational human experiential foraging paradigm which indexes naturalistic and clinically relevant decision-making. To determine its potential clinical utility, we examined the psychometric properties and clinical correlates of behavioural parameters extracted from WebSurf in an initial exploratory experiment and a pre-registered validation experiment. Behaviour was stable over repeated administrations of the task, as were individual differences. The ability to measure decision making consistently supports the potential utility of the task in predicting an individual’s propensity for response to psychiatric treatment, in evaluating clinical change during treatment, and in defining neurocognitive profiles that relate to psychopathology. Specific aspects of WebSurf behaviour also correlate with anhedonic and externalising symptoms. Importantly, these behavioural parameters may measure dimensions of psychological variance that are not captured by traditional rating scales. WebSurf and related paradigms might therefore be useful platforms for computational approaches to precision psychiatry.
Cell-Free Optimized Production of Protoporphyrin IX
Authors: Garcia David C. , Davies John P. , Rhea Katherine , Lee Marilyn , Lux Matthew W. 
Published: December 2023

ABSTRACTBackgroundThe asymmetric and aromatic structures of porphyrins enable semiconducting properties allowing them to absorb light to initiate complex photocatalytic activity. These properties coupled with biological origins have garnered these molecules and their derivatives wide interest as a biotechnological platform. However, porphyrin production in cells is challenging due to the limited titer, long production timescales, and difficult purification.ResultsA cell-free metabolic engineering platform was constructed to produce protoporphyrin IX (PPIX) fromE. colicrude extracts. Using acoustic liquid-handling, design of experiments for high-throughput buffer optimization and co-culturing techniques for extract production, our cell-free reactions effectively produced 0.109 mg/mL quantities of porphyrins.ConclusionsThe use of cell-free metabolic engineering as a bioproduction platform could improve the production of toxic or inefficient biomolecules such as PPIX. The engineering strategies including DOE and co-culturing applied in this study provide a roadmap towards increasing the scale of cell-free metabolic engineering by elucidating batch to batch variability, as well as the need for batch specific optimization of reaction conditions.
Prognostic relevance of correlated co-expression of coding and noncoding RNAs in cervical cancers
Authors: Ghosh Abhisikta , Sinha Abarna , Ghosh Arnab , Roy Somrita , Mallick Sumana , Kumar Vinoth , Mathai Sonia , Bhaumik Jaydip , Mukhopadhyay Asima , Sen Saugata , Chandra Aditi , Maitra Arindam , Biswas Nidhan K. , Majumder Partha P. , Sengupta Sharmila 
Published: December 2023

AbstractHuman papillomavirus (HPV) drives cervical cancer (CaCx) pathogenesis and viral oncoproteins jeopardize global gene expression in such cancers. We aimed to identify differentially expressed coding (DEcGs) and long noncoding (sense intronic and Natural Antisense Transcripts) RNA genes (DElncGs) in HPV16-positive CaCx patients (N=44) compared to HPV-negative normal individuals (N=34). Thereby, employing strand-specific RNA-seq, we determined the relationships between DEcGs and DElncGs and their clinical implications. Gene set enrichment and protein-protein interaction analyses of DEcGs revealed enrichment of processes crucial for abortive virus life cycle and cancer progression. The DEcGs formed 16 gene clusters, portraying cancer-related functions. We recorded significantly correlated co-expression of 79 DElncGs with DEcGs at proximal genomic loci, and 24 such pairs portrayed significantly altered correlation coefficients among patients, compared to normal individuals. Of these, 6 DEcGs belonged to 5 gene clusters, one of which was survival-associated. Out of the 24 correlated DEcG: DElncG pairs, 3 pairs were identified, where expression of both members was significantly associated with patient overall survival. Besides being prognostically relevant, disruption of the significant correlative relationships of such gene pairs in CaCx bears immense potential for patient-targeted therapy.Graphical Abstract:A schematic representation of the analyses undertaken to draw insights on the biological relevance of joint analysis of co-expressed and significantly correlated DElncGs and DEcGs considering the ncNATs and sense intronic DElncGs, in HPV16-positive CaCx patients compared with HPV-negative normal individuals.
Who wreaks more havoc? Gender and the detrimental effect of abusive supervision on interpersonal deviance
Authors: Wang Haizhen , Zhang Ruoyong 
Published: December 2023

Purpose
Abusive supervision provokes subordinates’ interpersonal deviant behavior. It is, therefore, essential to explore the contingent factors of this relationship. Drawing upon gender role theory, this study aims to explore how subordinate and leader genders moderate the relationship between abusive supervision and subordinate interpersonal deviance. Furthermore, this study posits a three-way interaction effect of abusive supervision with leader and subordinate genders on interpersonal deviance.

Design/methodology/approach
Multisource survey data were collected from 45 supervisors and 170 subordinates in eight companies in China. The data were analyzed using the PROCESS macro in SPSS.

Findings
The results showed that the positive relationship between abusive supervision and interpersonal deviance was stronger among female leaders than male leaders. Furthermore, the authors found a three-way interaction effect between abusive supervision and leader and subordinate genders on subordinates’ interpersonal deviance. Compared with female subordinates, male subordinates engaged in significantly more interpersonal deviance when experiencing abusive supervision from a female leader than from a male leader.

Originality/value
The authors reveal that gender differences exist in the effect of abusive supervision on subordinates’ interpersonal deviant behavior. Furthermore, the authors demonstrate that subordinate and leader genders jointly influence the effect of abusive supervision. Finally, the findings extend the literature on gender’s moderating effects from constructive and neutral leader behaviors to destructive leader behaviors.
Are firms more concerned about analysts’ earnings forecasts after the split-share structure reform? Evidence from China
Authors: Xi Xunzhuo , Chen Can , Huang Rong , Tang Feng 
Published: December 2023

Purpose
This study aims to examine whether Chinese firms increase their concerns about analysts’ earnings forecasts following the split-share structure reform (SSR) in 2005, which removed trading restrictions on approximately 70% of the shares of listed firms.

Design/methodology/approach
Using data from 2002 to 2019, the authors empirically test the association between meeting or beating analysts’ earnings expectations and the implementation of SSR.

Findings
The authors find that firms are more inclined to meet analysts’ earnings expectations after the introduction of SSR. Further analysis shows that firms guide analysts to walk their forecasts down by manipulating third-quarter earnings, suggesting enhanced value relevance between analysts’ forecasts and third-quarter earnings management in the postreform period.

Practical implications
The findings reveal an undesirable side effect of SSR and suggest that policymakers and regulators should consider and carefully manage the complex relationships between firms and analysts.

Originality/value
In contrast to prior studies that predominantly focus on the positive effects of the reform, this study reveals the side effects of SSR and provides new evidence on the mechanisms of meeting or beating analysts’ earnings expectations.