bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of lipid metabolism disorders in patients with coronavirus infection-COVID-19 with chronic hepatitis C
Authors: Temnik E. I. , Konstantinov D. Y. , Popova L. L. 
Published: November 2023

The aim of the study was to assess individual indicators of lipid metabolism in patients with novel coronavirus infection with chronic hepatitis C (CHC) depending on the severity of COVID-19 and liver fibrosis stage.Object and methods. A comparative analysis of the results of laboratory examination of patients of the following groups was carried out: group 1 (n = 147) – patients with COVID-19 and CHC, group 2 (n = 81) – patients with COVID-19, group 3 control (n = 94) patients with CHC without COVID-19. In turn, the patients of the first two groups were divided into subgroups according to the severity of the COVID-19: with moderate (A) and severe course (B). According to the liver fibrosis stage, patients with COVID-19 with CHC were divided into 3 subgroups: F1 (mild fibrosis), F2 (moderate fibrosis), F3 (severe fibrosis). In blood serum, lipid profile parameters (total cholesterol (TC), high-density lipoprotein cholesterol (CHDL), low-density lipoprotein cholesterol (CLDL), triglycerides (TG), apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B)) were evaluated. All parameters were assessed in the acute period, according to the severity of COVID-19 and the liver fibrosis stage.Results. In 100% of patients with COVID-19 and CHC, a decrease in Apo A1 and an increase in Apo B, the ratio of Apo B/Apo A1 were detected, regardless the severity of disease. In patients with severe COVID-19 with CHC, changes in the lipid spectrum were recorded: an increase in TG, Apo AI, Apo B, Apo B/Apo A1 ratio, and a decrease in CHDL, CLDL, Apo A1. In patients with COVID19 and severe liver fibrosis (CHC), a decrease in LDLC, Apo A1 and increase in CLDL, Apo B, ratio Apo B/Apo A1 was observed.
The effect of the A82G mutation in the MMP-12 gene and C634G mutation in the VEGF-A gene on the course of lower limb varicose veins and the risk of disease recurrence
Authors: Yarovenko G. V. , Katorkin S. E. , Komleva Y. M. , Osadchaya P. V. 
Published: November 2023

Aim: creation of a method for predicting the development of varicose veins of the lower extremities and its recurrence.Object and methods. 2 independent studies of patients with C2-C6 varicose veins of the lower extremities (CEAP-classifier) were conducted. In the first, with ultrasound diagnosis of the main veins of the lower extremities and genomic analysis of blood samples, 75 participants (men 20, women 55), mean age 43.7 ± 5.9 years. All patients were randomized into two groups: group I (n = 17) – with recurrent varicose veins; Group II (n = 58) – applied with varicose veins for the first time. The 2nd study involved 44 (men 10, women 34), mean age 55.5 ± 2.7 years. Similarly, patients were divided into groups – I (5) and II (39 people). All patients of the first stage of the study underwent real-time PCR with allele-specific primers to determine the A82G mutation in the MMP-12 gene (matrix metalloproteinase-12) and the second stage C634G in the VEGF-A gene (endothelial fibroblast growth factor – A).Results of the study. In patients of both groups I and II, having the MMP-12 gene in the heterozygous variant, dilatation of the tibial and popliteal veins was present (6.4 ± 0.3 mm and 10.7 ± 0.24 mm, respectively) with the presence reflux and slowing down the evacuation of blood from the deep venous system. In patients of group I, the MMP-12 gene was found in 80 % of cases, as A/A (homozygous) and A/G (heterozygous variation), while in group II only in 33.3 % of cases. Pearson's goodness-of-fit criterion χ2 = 10.4 (the critical value of the criterion is 6.63), p < 0.01. The frequency of recurrence of varicose veins and mutation of the MMP-12 gene according to the Spearman test was 1.0 with the number of degrees of freedom 23, p < 0.05. In the 2nd study, a correlation was found between groups I and II of patients with the C/C genotype (Pearson's coefficient χ2 = 0.79, p < 0.11) and a correlation in the duration of the disease between groups of patients with the C/C genotype (homozygous variation) and C /G (heterozygous variation) – Pearson correlation coefficient χ2 = 0.92 (p < 0.01).Conclusion. The revealed relationship between the MMP-12 gene polymorphism and the frequency of varicose vein recurrence is a predictor of the development of structural changes in the vein wall, and a mutation in the VEGF-A gene occurs with a long history of the disease.
Methods of early diagnosis and pharmacological prevention of pancreatitis after endoscopic papillosphincterotomy
Authors: Spiridonov T. R. , Novikova E. D. , El'cov T. O. 
Published: November 2023

Introduction. The most frequent complication of endoscopic papillosphincterotomy (EPST) is acute pancreatitis. This complication is supposed to be based on mechanical, chemical, hydrostatic, enzymatic and thermal impact on pancreatic ducts and parenchyma. According to different literature data, the incidence of post-EPST pancreatitis (PEP) varies from 30 to 40 %, and the mortality rate is 2–10 %.The aim of the investigation was to expand information about peculiarities of early diagnostics and prevention of post-EST pancreatitis at the present stage.Materials and methods. To reach the set goal we analyzed 559 case histories of patients with diagnosed cholelithiasis, 319 of them underwent EPST.Results. During the study it was found out, that elevated neutrophils/lymphocytes ratio over 4,96 (p = 0,001), high LDH level over 250 IU/ml (p = 0,01), as well as Creactive to albumin index over 0,180 (p = 0,001) are reliable markers of early diagnosis. Also, indirect diagnostic markers of PEEP are biochemical signs of cholestasis and cytolysis of hepatocytes, as well as hyperglycemia combined with glucosuria. We consider the inclusion of intraoperative injections of papillotomy wound margins with Epinephrine in combination with subsequent Somatostatin administration in combination with rectal Diclofenac and intravenous hydration with Reamberin to be the most effective strategy for PEP prevention.Conclusions. Thus, we can conclude that despite the ongoing research and the search for effective algorithms for the prevention and early diagnosis of PEP, their data often contradict each other or simply do not confirm their effectiveness. The problem of prevention and diagnosis of PEP remains complex and requires further study. There are discrepancies, sometimes significant ones, in the current literature, which provides grounds for the development and research of new methods of early diagnosis and prevention.
Multiple organ failure in patients with combined breast injury: diagnosis and treatment
Authors: Vladimirova E. S. , Chernousov F. A. , Badygov S. A. , Rey S. I. , Berdnikov G. A. , Klychnikova E. V. , Alekseechkina O. A. , Popova I. E. , Men'shikova E. D. 
Published: November 2023

Relevance. Modern methods of diagnosis and treatment of victims with severe combined trauma, the fulfillment of the conditions of the "golden hour" do not solve the problem of a favorable outcome, sepsis and multiple organ failure (PON) remain the main cause of death.The purpose of the study. To study the possibilities of complex diagnostics and treatment using combined methods of extracorporeal hemocorrection in patients with PON after severe combined breast injury.Object and methods. The results of diagnosis and treatment of 20 victims with combined chest injury were analyzed. The criteria for inclusion in the study were as follows: age over 18 years; severe combined closed chest injury: AIS > 2 on the background of combined injuries, ISS 28–34 points, severity of the condition on the ARASNE II scale over 20 points, the use of extracorporeal hemocorrection (MEG) methods.The results of the study. In patients with severe combined breast injury, the severity of the course of multiple organ failure is shown and the effectiveness of combined methods of extracorporeal hemocorrection (MEG), the features of manifestations of PON and the dynamics of changes in indicators against the background of complex treatment is determined. The main method of diagnosis of PON was a clinical and laboratory picture, taking into account coagulological, biochemical disorders, biomarkers of inflammation and instrumental assessment of CT of the lungs and ultrasound picture of the state of parenchymal organs of the chest and abdomen.Сonclusions. An integrated approach to the management of victims with PON, including early MEG, helps to reduce intoxication, stabilize the condition and increases life expectancy.
Morphological characteristics and diagnostic criteria of traditional serrated adenoma
Authors: Tertychnyy A. S. , Pachuashvili N. V. , Pavlov P. V. , Kiryukhin A. P. , Fedorenko A. A. , Marenich N. S. 
Published: November 2023

Traditional serrated adenomas (TSAs) are extremely rare polyps from the group of serrated polyps of the colon. TSAs is no more than 5 % of all colon polyps. A relatively small number of studies have been devoted to this histological variant, at the same time, some aspects of the morphological diagnosis of TSA still remain undisclosed. Purpose: to conduct a clinical and morphological analysis of cases of TSAs.Materials and methods. The study included 57 cases of TSAs diagnosed in the period from 2021 to 2023. In the cases detected during this period, the results of histological and endoscopic studies were analyzed.Results. The age of patients ranged from 44 to 78 years and averaged 61.7 years. The ratio of men and women is 1:1.8. Most TSAs were found in the rectum (n = 28) and sigmoid colon (n = 20). In 8 cases, the tumor was localized in the descending part and the splenic flexure of the colon. In 1 observation, a tumor was found in the cecum. The sizes of the polyps ranged from 0.5 cm to 3.5 cm. In 22 cases, the composition of the polyp included tubulovillous adenomas (16 cases) and hyperplastic polyps (6 cases) in addition to TSAs. In 5 cases, foci of highly differentiated adenocarcinoma were detected in the TSAs material.Conclusion. TSAs has characteristic morphological features with a serrated exophytic growth pattern, cytoplasmic eosinophilia and the presence of ectopic crypts. Due to the difficulties of morphological diagnosis, TSAs in some cases remains undiagnosed. At the same time, due to the increased malignant potential, TSAs requires special vigilance on the part of pathologists and clinicians.
Changes in the hormonal background of medical students in different periods of study, taking into account gender differences
Authors: Maslyakov V. V. , Pavlova O. N. , Habibrakhmanova L. H. , Gilfanov R. R. , Nakaeva E. Y. 
Published: November 2023

The purpose of the study. To conduct a study of hormonal changes in medical students in different periods of study, taking into account gender differences.Object and methods. In order to achieve this goal, a study of the main physiological indicators was conducted in 120 volunteer students aged from up 18 to 24 years. The following criteria were used for inclusion in the studies: the absence of acute or chronic diseases, which is confirmed by the availability of health certificates, the presence of the middle of the menstrual cycle (for women), obtaining consent to conduct the study.Conclusion. Changes in the hormonal background of medical students depend on gender and the course of study, the greatest changes in the hormonal background of students, 1–2 courses, and these changes occur regardless of gender, then, at 3–4 courses, there is some stabilization of the hormonal background, and this is more concerning for female representatives.
Physiological effects of using a high-protein, low-carbohydrate diet of pregnant and lactating female rats on the development of their offspring
Authors: Makarcheva A. A. , Romanova I. D. , Inyushkina E. M. , Zaynulin R. A. 
Published: November 2023

In the modern world, the nature of human nutrition is becoming more relevant. This is due to the spread of diseases such as diabetes mellitus, cardiovascular diseases and metabolic disorders. The health of a person and his offspring comes to the fore. In this regard, high-protein, low-carbohydrate diets are becoming popular at the moment.The aim of the study was to identify the effect of a high-protein, low-carbohydrate diet of pregnant and lactating female rats on the development of their offspring.Object and methods. The experiment was carried out on the offspring of female rats. The female rats of the control group received normal nutrition, and for the experimental group a special high-protein, low-carbohydrate diet was compiled, which was maintained throughout pregnancy and in the first week after delivery. As a result of the study, it was revealed that a diet with an increased protein content has a beneficial effect on the development of baby rats in delayed terms: they have a more pronounced weight gain, increased research activity and are less prone to anxiety.
A Method for Evaluating Reservoir Permeability Based on Machine Learning Flow Unit Index
Authors: Cheng Xincai , Zhao Bin , Gao Chuqiao , Gao Ying 
Published: November 2023

Abstract
The H formation of the Y gas field in the X depression belongs to a low-permeability tight sandstone reservoir affected by sedimentation, diagenesis, and cementation. The lithology and pore structure of the target layer are complex, with strong physical heterogeneity and complex pore-permeability relationships. Conventional core pore permeability regression and nuclear magnetic resonance software-defined radio methods do not satisfy the requirements for precise evaluation in terms of permeability calculation accuracy. Based on the principle of the flow zone index (FZI) method, this study analyzed the influence of pore structure on permeability and extracted three pore structure characterization parameters, namely, the maximum pore throat radius (Rmax), displacement pressure (Pd), and average throat radius (R), from the mercury injection capillary pressure curve. The relationship between the FZI and pore structure is clarified. Therefore, the FZI in this area can characterize the permeability differences within different flow units. Based on the flow unit theory, a refined evaluation model for three types of reservoirs was established in the study area. By analyzing the response characteristics and correlation of conventional logging curves using machine learning, three optimization combination curves were selected, and a multiparameter fitting equation for the FZI was established, which was applied to predict the permeability of new wells. The results showed that the calculated permeability was highly consistent with the core analysis results, thereby providing a theoretical basis for the precise evaluation of low-permeability tight reservoirs.
Method for Predicting Transverse Wave Velocity Using a Gated Recurrent Unit Based on Spatiotemporal Attention Mechanism
Authors: Huang Jiaxin , Gao Gang , Li Xiaoming , Li Yonggen , Gui Zhixian 
Published: November 2023

Abstract
Transverse wave velocity plays an important role in seismic exploration and reservoir assessment in the oil and gas industry. Due to the lack of transverse wave velocity data from actual production activities, it is necessary to predict transverse wave velocity based on longitudinal wave velocity and other reservoir parameters. This paper proposes a fusion network based on spatiotemporal attention mechanism and gated recurrent unit (STAGRU) due to the significant correlation between the transverse wave velocity and reservoir parameters in the spatiotemporal domain. In the case of tight sandstone reservoirs in the Junggar Basin, the intersection plot technique is used to select four well logging parameters that are sensitive to transverse wave velocity: longitudinal wave velocity, density, natural gamma, and neutron porosity. The autocorrelation technique is employed to analyze the depth-related correlation of well logging curves. The relationship between the spatiotemporal characteristics of these well logging data and the network attention weights is also examined to validate the rationale behind incorporating the spatiotemporal attention mechanism. Finally, the actual measurement data from multiple wells are utilized to analyze the performance of the training set and test set separately. The results indicate that the predictive accuracy and generalization ability of the proposed STAGRU method are superior to the single-parameter fitting method, multiparameter fitting method, Xu-White model method, GRU network, and 2DCNN-GRU hybrid network. This demonstrates the feasibility of the transverse wave velocity prediction method based on the spatiotemporal attention mechanism in the study of rock physics modeling for tight sandstone reservoirs.
A Long-Lived Accretionary Process during the Amalgamation of the North China Craton: Insights from Neoarchean–Paleoproterozoic Polyphase Magmatism in the Lüliang Complex
Authors: Yu Xinyuan , Zhang Jian , Liu Jin , Yin Changqing , Chen Ying , Guo Minjie , Qian Jiahui , Gao Peng , Cheng Changquan 
Published: November 2023

Abstract
There has been a long debate regarding the timing of the final amalgamation of the North China Craton, which is considered to have occurred either during the Neoarchean or Paleoproterozoic era. One major point of contention is whether there existed a long-lived subduction lasting through the Neoarchean to Paleoproterozoic. The Lüliang Complex contains multiphases of magmatism and thus represents the most viable region to address this controversy. In this study, we carried geochronological and geochemical analysis on the representative granitoids. Secondary ion mass spectrometry U–Pb dating revealed four distinct granitoid groups emplaced at 2531 ± 4, 2189–2173, 2027 ± 25, and 1852 ± 41 Ma, respectively. Notably, the 2531 Ma granitic gneiss was identified for the first time in this region. Based on the geochemical characteristics, the granitoids can be divided into two types. The 2531 and 2027 Ma groups display I-type features, while the 2189–2173 and 1852 Ma groups exhibit A-type geochemical affinities. Both I-type groups exhibit enrichment in Rb, depletion in Nb, Ta, and Ti, moderate fractionated REE patterns, substantial negative Eu anomalies, low Sr/Y ratios, and positive εHf(t) (+3.51 to +5.53 and +5.59 to +7.32, respectively), indicating that they were generated from partial melting of the juvenile mafic crust. In contrast, the 2189–2173 Ma granitoids belong to A2-type and were most likely generated by the partial melting of felsic rocks in the back-arc region, while the 1852 Ma granitoids belong to A1-type and were most possibly the result of partial melting of mafic-intermediate rocks during the post-collisional stage. Based on the records of A-type granitic magmatism and the ~1950 Ma peak metamorphism throughout the Trans-North China Orogen, we propose that a long-lived subduction process (2531–1950 Ma) can mostly explain the existing geological phenomena. It is likely that the subduction between the Eastern and Western Blocks should have commenced at ~2531 Ma, followed by a long-lived subduction. The two blocks ultimately collided with each other to form the North China Craton at ~1950 Ma, which triggered post-collisional exhumation and partial melting at ~1852 Ma.
PhyloBench: a Benchmark for Evaluating Phylogenetic Programs
Authors: Spirin Sergey , Sigorskikh Andrey , Efremov Aleksei , Penzar Dmitry , Karyagina Anna 
Published: November 2023

Abstract

Motivation. Phylogenetic inference based on protein sequence alignment is a widely used procedure. Numerous phylogenetic algorithms have been developed, most of which have many parameters and options. Choosing a program, options, and parameters can be a nontrivial task. No benchmark for comparison of phylogenetic programs on real protein sequences is publicly available.
Results. We have developed PhyloBench, a benchmark for evaluating the quality of phylogenetic inference, and used it to test a number of popular phylogenetic programs. PhyloBench is based on natural, not simulated, protein sequences of orthologous evolutionary domains. The measure of accuracy of an inferred tree is its distance to the corresponding species tree. A number of tree-to-tree distance measures were tested. The most reliable results were obtained using the Robinson–Foulds distance. Our results confirmed recent findings that distance methods are more accurate than maximum likelihood and maximum parsimony. We tested the bayesian program MrBayes on natural protein sequences and found that it is superior to maximum likelihood, but inferior to distance methods. Of the methods we tested, the Balanced Minimum Evolution method implemented in FastME yielded the best results.
Availability. Alignments and reference species trees are available at https://mouse.belozersky.msu.ru/tools/phylobench/ together with a web-interface that allows for a semi-automatic comparison of a user’s method with a number of popular programs.
Taxonomic status and phylogeographical structure in Pseudonereis sp. East Asia in the East China Sea off the Coast of Zhejiang, China
Authors: Chen Yongjiu , Khalfan Zahor Mwalim , Liang Zibin 
Published: November 2023

Abstract

Pseudonereis variegatais a polychaeteous worm (Annelida: Nereididae) with a cosmopolitan distribution in coastal waters; however, noticeable variations in morphology and genetics raised the question whether individuals from distinct ocean basins belong to the same species. This study evaluated the taxonomic status and phylogeographic structure inPseudonereissp. East Asia (asP. variegata) in the East China Sea (ECS) off the Coast of Nanji Islands (NJ) and Zhoushan Islands (ZS), Zhejiang by analyzing a 582bp DNA sequence in mitochondrial cytochrome C oxidase subunit I (COI). A total of 36 haplotypes were scored from 152 specimens, including 40 from ZS and 112 from NJ. Between NJ and ZS, 5 haplotypes were in common. Relatively, the levels of diversity on NJ (Hd = 0.556±0.060, π = 0.149±0.023%) were higher than ZS (Hd = 0.478±0.099, π = 0.110±0.028%). Comparative analyses with morphological characters andCOIsequences of congeneric samples derived from other locations indicated thatPseudonereissp. East Asia in the West Pacific, including the East China Sea/Taiwan Strait (ECS-TS) and Yellow Sea (YS) had a strong and significant divergence from the conspecific specimens in Chile and thus they should be described as a separate species, namelyPseudonereissp. East Asia. The lack of noticeable phylogeographic structuring observed among populations inPseudonereissp. East Asia is probably due to larval transportation and oceanographic connection via the coastal currents. Our study provides basic scientific information for understanding the identity and genetic diversity ofPseudonereissp. East Asia in the East China Sea off the Coast of Zhejiang, China and neighboring areas.