bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occlusal Architecture of the Buried Interface Enables Record‐Efficiency Flexible Perovskite Photovoltaic Modules with Enhanced In‐Plane Bending Mechanical Endurance
Authors: Zhang Cuiling , He Mingzhu , Wu Shaohang , Gao Yanyan , Ma Mengen , Liu Chong , Mai Yaohua 
Published: January 2024

AbstractFlexible perovskite photovoltaic cells (f‐PPCs) have demonstrated enormous potential in portable electronics due to the high power‐to‐weight ratio characteristic in outdoor and indoor ambient environment. However, the inherent mechanical endurance of f‐PPCs remains a major concern. Inspired by industrial strong adhesion coatings, herein, a porous nanoparticle layer is inserted into the buried interface of the perovskite layer to regulate the interfacial adhesion with a smooth hole transporting layer (HTL). As a result, the f‐PPCs realizes retaining over 80% of original efficiency after 2000 in‐plane bending cycles with the narrow radius of 4 mm. Furthermore, a certified record efficiency of 20.20% is achieved for flexible perovskite solar module, as well as the record efficiency of 31.69% for flexible perovskite indoor photovoltaic module (LED, 1000 lux).
Introduction of SnS2 to Regulate the Ferrous Disulfide Phase Evolution for the Construction of Triphasic Heterostructures Enabling Kinetically Accelerated and Durable Sodium Storage
Authors: Zhao Zibo , Sun Guang , Zhang Yiming , Hua Ran , Wang Xiting , Wu Naiteng , Li Jin , Liu Guilong , Guo Donglei , Cao Ang , Liu Xianming , Hou Hongshuai 
Published: January 2024

AbstractTransition metal sulfides (TMSs) still confront the challenges of capacity fading and inferior fast‐charging capability for sodium storage. The rational design of heterostructures enables a new approach to conquer these drawbacks. In this work, a hierarchical structure consisting of SnS2 nanosheets and FeS2 microrods with triphasic heterostructures is proposed by the facile secondary growth and sulfidation process. The introduction of tin sources regulates the proportion of pyrite and marcasite phases, thereby achieving the triphasic heterostructures comprising pyrite, marcasite FeS2, and SnS2. When served as anode material for sodium‐ion batteries, the optimized sample exhibits a high reversible capacity (901 mAh g−1) and durable cycling performances (827 mAh g−1 after 200 cycles at 1 A g−1 and 742 mAh g−1 after 700 cycles at 5 A g−1). Paring with the commercial Na3V2(PO3)3 cathodes, the full‐cell also delivers extraordinary cyclic stability with a high capacity of 618 mAh g−1 (based on the weight of anode material) after 200 cycles at 1 A g−1 (98.7% capacity retention). The hierarchical structure with adjustably triphasic heterogeneous interfaces alleviates the volumetric expansion and interfacial passivation of active material, while modulating the energy band structure and inducing the build‐in electric fields to boost Na+/electrons transport rate.
Oxygen Vacancy Defect Enhanced NIR‐II Photothermal Performance of BiOxCl Nanosheets for Combined Phototherapy of Cancer Guided by Multimodal Imaging
Authors: Fang Qianlan , Hong Chengyuan , Liu Zhusheng , Pan Yuning , Lin Jie , Zheng Jianjun , Zhang Jingfeng , Chen Tianxiang , Ma Xuehua , Wu Aiguo 
Published: January 2024

AbstractNarrow photo‐absorption range and low carrier utilization are significant barriers that restrict the antitumor efficiency of 2D bismuth oxyhalide (BiOX, X = Cl, Br, I) nanosheets (NSs). Introducing oxygen vacancy (OV) defects can expand the absorption range and improve carrier utilization, which are crucial but also challenging. In this study, a series of BiOxCl NSs with different OV defect concentrations (x = 1, 0.7, 0.5) is developed, which shows full spectrum absorption and strong absorption in the second near‐infrared region (NIR‐II). Density functional theory calculations are utilized to calculate the crystal structure and density states of BiOxCl, which confirm that part of the carriers is separated by OV enhanced internal electric field to improve carrier utilization. The carriers without redox reaction can be trapped in the OV, leading to great majority of photo‐generated carriers promoting the photothermal performance. Triggered by single NIR‐II (1064 nm), BiOxCl NSs’ bidirectional efficient utilization of carriers achieves synchronously combined phototherapy, leading to enhanced tumor ablation and multimodal diagnostic in vitro and vivo. It is thus believed that this work provides an innovative strategy to design and construct nanoplatforms of indirect band gap semiconductors for clinical phototheranostics.
How to Build Plasmon‐Driven Molecular Jackhammers that Disassemble Cell Membranes and Cytoskeletons in Cancer
Authors: Ayala‐Orozco Ciceron , Li Gang , Li Bowen , Vardanyan Vardan , Kolomeisky Anatoly B. , Tour James M. 
Published: January 2024

AbstractPlasmon‐driven molecular machines with ultrafast motion at the femtosecond scale are effective for the treatment of cancer and other diseases. It is recently shown that cyanine dyes act as molecular jackhammers (MJH) through vibronic (vibrational and electronic mode coupling) driven activation that causes the molecule to stretch longitudinally and axially through concerted whole molecule vibrations. However, the theoretical and experimental underpinnings of these plasmon‐driven motions in molecules are difficult to assess. Here the use of near‐infrared (NIR) light‐activated plasmons in a broad array of MJH that mechanically disassemble membranes and cytoskeletons in human melanoma A375 cells is described. The characteristics of plasmon‐driven molecular mechanical disassembly of supramolecular biological structures are observed and recorded using real‐time fluorescence confocal microscopy. Molecular plasmon resonances in MJH are quantified through a new experimental plasmonicity index method. This is done through the measurement of the UV–vis–NIR spectra in various solvents, and quantification of the optical response as a function of the solvent polarity. Structure‐activity relationships are used to optimize the synthesis of plasmon‐driven MJH, applying them to eradicate human melanoma A375 cells at low lethal concentrations of 75 nm and 80 mW cm−2 of 730 nm NIR‐light for 10 min.
SHMT2 Mediates Small‐Molecule‐Induced Alleviation of Alzheimer Pathology Via the 5′UTR‐dependent ADAM10 Translation Initiation
Authors: Song Li , Pan Qiu‐Ling , Zhou Gui‐Feng , Liu Sheng‐Wei , Zhu Bing‐Lin , Lin Pei‐Jia , Hu Xiao‐Tong , Zha Jing‐Si , Long Yan , Luo Biao , Chen Jian , Tang Ying , Tang Jing , Xiang Xiao‐Jiao , Xie Xiao‐Yong , Deng Xiao‐Juan , Chen Guo‐Jun 
Published: January 2024

AbstractIt is long been suggested that one‐carbon metabolism (OCM) is associated with Alzheimer's disease (AD), whereas the potential mechanisms remain poorly understood. Taking advantage of chemical biology, that mitochondrial serine hydroxymethyltransferase (SHMT2) directly regulated the translation of ADAM metallopeptidase domain 10 (ADAM10), a therapeutic target for AD is reported. That the small‐molecule kenpaullone (KEN) promoted ADAM10 translation via the 5′ untranslated region (5′UTR) and improved cognitive functions in APP/PS1 mice is found. SHMT2, which is identified as a target gene of KEN and the 5′UTR‐interacting RNA binding protein (RBP), mediated KEN‐induced ADAM10 translation in vitro and in vivo. SHMT2 controls AD signaling pathways through binding to a large number of RNAs and enhances the 5′UTR activity of ADAM10 by direct interaction with GAGGG motif, whereas this motif affected ribosomal scanning of eukaryotic initiation factor 2 (eIF2) in the 5′UTR. Together, KEN exhibits therapeutic potential for AD by linking OCM with RNA processing, in which the metabolic enzyme SHMT2 “moonlighted” as RBP by binding to GAGGG motif and promoting the 5′UTR‐dependent ADAM10 translation initiation.
Short‐wave Infrared Photoluminescence Lifetime Mapping of Rare‐Earth Doped Nanoparticles Using All‐Optical Streak Imaging
Authors: Liu Miao , Lai Yingming , Marquez Miguel , Vetrone Fiorenzo , Liang Jinyang 
Published: January 2024

AbstractThe short‐wave infrared (SWIR) photoluminescence lifetimes of rare‐earth doped nanoparticles (RENPs) have found diverse applications in fundamental and applied research. Despite dazzling progress in the novel design and synthesis of RENPs with attractive optical properties, existing optical systems for SWIR photoluminescence lifetime imaging are still considerably restricted by inefficient photon detection, limited imaging speed, and low sensitivity. To overcome these challenges, SWIR photoluminescence lifetime imaging microscopy using an all‐optical streak camera (PLIMASC) is developed. Synergizing scanning optics and a high‐sensitivity InGaAs CMOS camera, SWIR‐PLIMASC has a 1D imaging speed of up to 138.9 kHz in the spectral range of 900–1700 nm, which quantifies the photoluminescence lifetime of RENPs in a single shot. A 2D photoluminescence lifetime map can be acquired by 1D scanning of the sample. To showcase the power of SWIR‐PLIMASC, a series of core‐shell RENPs with distinct SWIR photoluminescence lifetimes is synthesized. In particular, using Er3+‐doped RENPs, SWIR‐PLIMASC enables multiplexed anti‐counterfeiting. Leveraging Ho3+‐doped RENPs as temperature indicators, this system is applied to SWIR photoluminescence lifetime‐based thermometry. Opening up a new avenue for efficient SWIR photoluminescence lifetime mapping, this work is envisaged to contribute to advanced materials characterization, information science, and biomedicine.
DeepFreeze 3D‐biofabrication for Bioengineering and Storage of Stem Cells in Thick and Large‐Scale Human Tissue Analogs
Authors: Kumar Alok , Brown Robert A. , Roufaeil Daniel Benyamien , Gupta Aditi , Lipford Erika L. , Muthusamy Divya , Zalzman Amihai , Hertzano Ronna , Lowe Tao , Stains Joseph P. , Zalzman Michal 
Published: January 2024

Abstract3D bioprinting holds great promise for meeting the increasing need for transplantable tissues and organs. However, slow printing, interlayer mixing, and the extended exposure of cells to non‐physiological conditions in thick structures still hinder clinical applications. Here the DeepFreeze‐3D (DF‐3D) procedure and bioink for creating multilayered human‐scale tissue mimetics is presented for the first time. The bioink is tailored to support stem cell viability, throughout the rapid freeform DF‐3D biofabrication process. While the printer nozzle is warmed to room temperature, each layer solidifies at contact with the stage (‐80 °C), or the subsequent layers, ensuring precise separation. After thawing, the encapsulated stem cells remain viable without interlayer mixing or delamination. The composed cell‐laden constructs can be cryogenically stored and thawed when needed. Moreover, it is shown that under inductive conditions the stem cells differentiate into bone‐like cells and grow for months after thawing, to form large tissue‐mimetics in the scale of centimeters. This is important, as this approach allows the generation and storage of tissue mimetics in the size and thickness of human tissues. Therefore, DF‐3D biofabrication opens new avenues for generating off‐the‐shelf human tissue analogs. It further holds the potential for regenerative treatments and for studying tissue pathologies caused by disease, tumor, or trauma.
Disentangling the Activity‐Stability Trade‐Off of Pyrrolic N‐Coordinated Fe─N4 Catalytic Sites for Long‐Life Oxygen Reduction Reaction in Acidic Medium
Authors: Xue Dongping , Zhao Shuyan , Lu Bang‐An , Yu Yue , Wei Yifan , Yin Hengbo , Hu Jin‐Song , Zhang Jianan 
Published: January 2024

AbstractFe─N─C materials with Fe─N4 sites are considered as most promising non‐precious metal‐based electrocatalysts for low‐cost proton‐exchange‐membrane fuel cells (PEMFCs). Breaking the trade‐off between activity and stability has been a long‐standing challenge in the field of acidic oxygen reduction reaction (ORR). Herein, a “top‐down” thermally‐driven strategy is developed to achieve highly active pyrrolic N‐coordinated Fe sites in a high spin state with Fe atomic cluster (Fen@Fe─Npyrr─C) and discover that the neighboring Fen cluster can synergistically stabilize such vulnerable Fe─N4 sites by inhibiting their protonation. Consequently, the Fen@Fe─Npyrr─C catalysts exhibit much enhanced ORR activity and stability, endowing PEMFCs with a high power density of 804.6 mW cm−2 (testing conditions: 80 °C, 100% RH, 2.0 bar) and over 100 h durability (at 0.5 V). These findings open up opportunities for the exploration of durable Fe─N─C ORR electrocatalysts for non‐precious metal‐based PEMFCs and other applications.
Covid‐19 and agricultural labor supply: Evidence from the rural–urban interface of an Indian mega‐city
Authors: Preusse Verena , Silva Manuel Santos , Steinhübel Linda , Wollni Meike 
Published: January 2024

AbstractThis paper examines how India's national lockdown (March 25–May 31, 2020), in response to the spread of Covid‐19, affected the on‐farm family labor supply of 351 farm households in the rural–urban interface of Bangalore. We combine face‐to‐face survey data collected just before the start of the lockdown with phone survey data collected during the last 2 weeks of the lockdown. We find that 66% of farm households reduced their daily on‐farm family labor supply during the lockdown, by on average almost 40% compared with prelockdown levels. Changes in on‐farm family labor supply differed by key pre‐Covid‐19 household characteristics. Farm households that were engaged in crop marketing decreased their on‐farm family labor supply by an average of 3–4 h/day. In turn, farm households that relied on off‐farm income increased their on‐farm family labor supply by on average 3–4 h/day [EconLit Citations: J22, J43, Q12, Q13, Q54].
Genetic risk score for Alzheimer's disease predicts brain volume differences in mid and late life in UK biobank participants
Authors: Buto Peter T. , Wang Jingxuan , La Joie Renaud , Zimmerman Scott C. , Glymour M. Maria , Ackley Sarah F. , Hoffmann Thomas J. , Yaffe Kristine , Zeki Al Hazzouri Adina , Brenowitz Willa D. 
Published: January 2024

AbstractINTRODUCTIONWe estimated the ages when associations between Alzheimer's disease (AD) genes and brain volumes begin among middle‐aged and older adults.METHODSAmong 45,616 dementia‐free participants aged 45–80, linear regressions tested whether genetic risk score for AD (AD‐GRS) had age‐dependent associations with 38 regional brain magnetic resonance imaging volumes. Models were adjusted for sex, assessment center, genetic ancestry, and intracranial volume.RESULTSAD‐GRS modified the estimated effect of age (per decade) on the amygdala (−0.41 mm3 [−0.42, −0.40]); hippocampus (−0.45 mm3 [−0.45, −0.44]), nucleus accumbens (−0.55 mm3 [−0.56, −0.54]), thalamus (−0.38 mm3 [−0.39, −0.37]), and medial orbitofrontal cortex (−0.23 mm3 [−0.24, −0.22]). Trends began by age 45 for the nucleus accumbens and thalamus, 48 for the hippocampus, 51 for the amygdala, and 53 for the medial orbitofrontal cortex. An AD‐GRS excluding apolipoprotein E (APOE) was additionally associated with entorhinal and middle temporal cortices.DISCUSSIONAPOE and other genes that increase AD risk predict lower hippocampal and other brain volumes by middle age.
A blood‐based multi‐pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups
Authors: Jiang Yuanbing , Uhm Hyebin , Ip Fanny C. , Ouyang Li , Lo Ronnie M. N. , Cheng Elaine Y. L. , Cao Xiaoyun , Tan Clara M. C. , Law Brian C. H. , Ortiz‐Romero Paula , Puig‐Pijoan Albert , Fernández‐Lebrero Aida , Contador José , Mok Kin Y. , Hardy John , Kwok Timothy C. Y. , Mok Vincent C. T. , Suárez‐Calvet Marc , Zetterberg Henrik , Fu Amy K. Y. , Ip Nancy Y. 
Published: January 2024

AbstractINTRODUCTIONExisting blood‐based biomarkers for Alzheimer's disease (AD) mainly focus on its pathological features. However, studies on blood‐based biomarkers associated with other biological processes for a comprehensive evaluation of AD status are limited.METHODSWe developed a blood‐based, multiplex biomarker assay for AD that measures the levels of 21 proteins involved in multiple biological pathways. We evaluated the assay's performance for classifying AD and indicating AD‐related endophenotypes in three independent cohorts from Chinese or European‐descent populations.RESULTSThe 21‐protein assay accurately classified AD (area under the receiver operating characteristic curve [AUC] = 0.9407 to 0.9867) and mild cognitive impairment (MCI; AUC = 0.8434 to 0.8945) while also indicating brain amyloid pathology. Moreover, the assay simultaneously evaluated the changes of five biological processes in individuals and revealed the ethnic‐specific dysregulations of biological processes upon AD progression.DISCUSSIONThis study demonstrated the utility of a blood‐based, multi‐pathway biomarker assay for early screening and staging of AD, providing insights for patient stratification and precision medicine.Highlights
The authors developed a blood‐based biomarker assay for Alzheimer's disease.
The 21‐protein assay classifies AD/MCI and indicates brain amyloid pathology.
The 21‐protein assay can simultaneously assess activities of five biological processes.
Ethnic‐specific dysregulations of biological processes in AD were revealed.
Polymer‐Protein Assemblies with Tunable Vesicular and Hierarchical Nanostructures
Authors: Ren Yingying , Guan Shanyue , Qu Xiaozhong 
Published: January 2024

AbstractThe construction of variable structured multi‐protein nano‐assemblies is of great interest for the development of protein‐based therapeutic systems. This study showcases the synthesis of polymer‐protein assemblies with tunable structure like single‐ and multi‐layer polymer‐crosslinked protein vesicles, Janus protein vesicles and other hierarchical‐structured assemblies by utilizing a dynamic template‐assistant intermittent‐assembly approach. The generalization of the methodology helps the protein assemblies to gain notable functional complexity. And we demonstrate compelling evidence highlighting the substantial impact of the topological morphology of protein nanoaggregates on their cellular uptake capacity.
Electrochemical Hydrophobic Tri‐layer Interface Rendered Mechanically Graded Solid Electrolyte Interface for Stable Zinc Metal Anode
Authors: Liu Chaozheng , Xu Wangwang , Zhang Lei , Zhang Daotong , Xu Weina , Liao Xiaobin , Chen Weimin , Cao Yizhong , Li Mei‐Chun , Mei Changtong , Zhao Kangning 
Published: January 2024

AbstractThe aqueous zinc‐ion battery is promising as grid scale energy storage device, but hindered by the instable electrode/electrolyte interface. Herein, we report the lean‐water ionic liquid electrolyte for aqueous zinc metal batteries. The lean‐water ionic liquid electrolyte creates the hydrophobic tri‐layer interface assembled by first two layers of hydrophobic OTF− and EMIM+ and third layer of loosely attached water, beyond the classical Gouy–Chapman–Stern theory based electrochemical double layer. By taking advantage of the hydrophobic tri‐layer interface, the lean‐water ionic liquid electrolyte enables a wide electrochemical working window (2.93 V) with relatively high zinc ion conductivity (17.3 mS/cm). Furthermore, the anion crowding interface facilitates the OTF− decomposition chemistry to create the mechanically graded solid electrolyte interface layer to simultaneously suppress the dendrite formation and maintain the mechanical stability. In this way, the lean‐water based ionic liquid electrolyte realizes the ultralong cyclability of over 10000 cycles at 20 A/g and at practical condition of N/P ratio of 1.5, the cumulated areal capacity reach 1.8 Ah/cm2, which outperforms the state‐of‐the‐art zinc metal battery performance. Our work highlights the importance of the stable electrode/electrolyte interface stability, which would be practical for building high energy grid scale zinc‐ion battery.
Ionic Liquid‐Mediated Dynamic Polymerization for Facile Aqueous‐Phase Synthesis of Enzyme‐Covalent Organic Framework Biocatalysts
Authors: Gao Rui , Kou Xiaoxue , Tong Linjing , Li Zhi‐Wei , Shen Yujian , He Rongwei , Guo Lihong , Wang Hao , Ma Xiaomin , Huang Siming , Chen Guosheng , Ouyang Gangfeng 
Published: January 2024

AbstractUtilizing covalent organic framework (COF) as a hypotoxic and porous scaffold to encapsulate enzyme (enzyme@COF) has inspired numerous interests at the intersection of chemistry, materials, and biological science. In this study, we report a convenient scheme for one‐step, aqueous‐phase synthesis of highly crystalline enzyme@COF biocatalysts. This facile approach relies on an ionic liquid (2 μL of imidazolium ionic liquid)‐mediated dynamic polymerization mechanism, which can facilitate the in situ assembly of enzyme@COF under mild conditions. This green strategy is adaptive to synthesize different biocatalysts with highly crystalline COF “exoskeleton”, as well evidenced by the low‐dose cryo‐EM and other characterizations. Attributing to the rigorous sieving effect of crystalline COF pore, the hosted lipase shows non‐native selectivity for aliphatic acid hydrolysis. In addition, the highly crystalline linkage affords COF “exoskeleton” with higher photocatalytic activity for in situ production of H2O2, enabling us to construct a self‐cascading photo‐enzyme coupled reactor for pollutants degradation, with a 2.63‐fold degradation rate as the poorly crystalline photo‐enzyme reactor. This work showcases the great potentials of employing green and trace amounts of ionic liquid for one‐step synthesis of crystalline enzyme@COF biocatalysts, and emphasizes the feasibility of diversifying enzyme functions by integrating the reticular chemistry of a COF.
Enhanced TROSY Effect in [2‐19F, 2‐13C] Adenosine and ATP Analogs Facilitates NMR Spectroscopy of Very Large Biological RNAs in Solution
Authors: Juen Fabian , Glänzer David , Plangger Raphael , Kugler Valentina , Fleischmann Jakob , Stefan Eduard , Case David A. , Kovacs Helena , Kwaku Dayie Theodore , Kreutz Christoph 
Published: January 2024

AbstractLarge RNAs are central to cellular functions, but characterizing such RNAs remains challenging by solution NMR. We present two labeling technologies based on [2‐19F, 2‐13C]‐adenosine, which allow the incorporation of aromatic 19F‐13C spin pairs. The labels when coupled with the transverse relaxation optimized spectroscopy (TROSY) enable us to probe RNAs comprising up to 124 nucleotides. With our new [2‐19F, 2‐13C]‐adenosine‐phosphoramidite, all resonances of the human hepatitis B virus epsilon RNA could be readily assigned. With [2‐19F, 2‐13C]‐adenosine triphosphate, the 124 nt pre‐miR‐17‐NPSL1‐RNA was produced via in vitro transcription and the TROSY spectrum of this 40 kDa [2‐19F, 2‐13C]‐A‐labeled RNA featured sharper resonances than the [2‐1H, 2‐13C]‐A sample. The mutual cancelation of the chemical‐shift‐anisotropy and the dipole‐dipole‐components of TROSY‐resonances leads to narrow linewidths over a wide range of molecular weights. With the synthesis of a non‐hydrolysable [2‐19F, 2‐13C]‐adenosine‐triphosphate, we facilitate the probing of co‐factor binding in kinase complexes and NMR‐based inhibitor binding studies in such systems. Our labels allow a straightforward assignment for larger RNAs via a divide‐and‐conquer/mutational approach. The new [2‐19F, 2‐13C]‐adenosine precursors are a valuable addition to the RNA NMR toolbox and will allow the study of large RNAs/RNA protein complexes in vitro and in cells.