bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the clinical use and impact of Miao medicine's anti influenza mask on IgA in human serum and SIgA in nasal mucosa
Authors: Wang Menglong , Xiao Yang , Wang Zhiqiong , Gan Lin , Zhou Xixi , Zeng Yiju 
Published: January 2024

Purpose: To investigate the clinical use of anti-influenza mask of Miao medicine, and its effect on human serum immunoglobulin A (IgA) as well as nasal mucosa secretory immunoglobulin A (SIgA).
Methods: 500 patients without COVID-19 in QianDongNanZhou Hospital of Traditional Chinese Medicine from January 2020 to September 2022 were selected and randomly divided into study and control groups, with 250 patients in each group. Both groups wore masks for three months. Control group was given disposable medical surgical three-layer melt-blown non-woven masks, while study group was given Miao medicine anti-infection masks. Serum IgA and SIgA levels were compared before and after wearing masks in both groups.
Results: Prior to intervention, serum IgA and SIgA levels in nasal mucosa were not significantly different (p > 0.05). There were also no significant differences in blood IgA levels between control and study groups. Before wearing masks, the study group had higher levels of blood IgA and nasal mucosal SIgA than control group. After wearing masks, nasal mucosa SIgA antibody levels and blood IgA antibody levels were significantly higher in the study group compared to control group (p < 0.001). The frequency of adverse responses did not significantly differ between the two groups (p > 0.05).
Conclusion: Miao medicine anti-infection masks are safe and raise serum levels of COVID-19 IgA antibodies and nasal mucosa SIgA levels in populations susceptible to COVID-19. These properties need to be compared among different races for the purpose of validation
Gefitinib enhances healing of long bone fractures in rats via inhibition of the epidermal growth factor receptor signal pathway
Authors: Shen Aofei , Wang Mengwei , Li Xiangheng 
Published: January 2024

Purpose: To investigate the influence of gefitinib on healing of long bone fractures in rats, and the involvement of epidermal growth factor receptor (EGFR) signal route in the process.
Methods: A model of long bone fracture was established in 30 Sprague-Dawley (SD) rats which were allocated to control and study groups (n = 15/group). Rats in study group received gefitinib (100 mg/kg per day) via gavage, while control rats were given 0.55 % methylcellulose daily for 7 - 42 days. Fracture healing, maximum callus diameter, serum levels of bone markers and mRNA levels of bone turnover indices in the callus, were determined.
Results: Following 1 week of therapy, fracture lines were clear in both groups, and callus was produced. On days 7, 14, 21, and 28, maximum callus diameter of study group was significantly higher than that of control group (p < 0.05). However, there was no significant difference in the maximum callus diameter between the two groups after 42 days (p > 0.05). On days 7, 14 and 21, there were significantly higher BALP and PINP levels, and TRACP-5b and CTX values in study group than in control (p < 0.05). On days 7 and 14, study group COLa1 mRNA and osteocalcin (OC) mRNA was significantly raised, relative to control values. On days 7, 14 and 21, COL10 mRNA expression was significantly up-regulated in study group relative to controls (p < 0.05). However, mRNA expression levels of COLa1, OC, COL10, and COL2A1 were similar in both groups at other time points.
Conclusion: Gefitinib enhances the healing of long bone fractures and callus formation in rats, probably through inhibition of EGFR signaling pathway. Therefore, gefitinib is beneficial in bone formation in rats.
Doctor's Legal Responsibility in Telemedicine Services
Authors: Sanusi Sanusi , Rediyano Rediyano , Wulan Endah Ratna , Qomarddin Muhammad 
Published: January 2024

Religion has been linked to mental health over the years, but its connection to persecutory ideation remains unclear. In this study, Nassarawa State University students' persecutory ideation is examined in relation to religious characteristics as predictors. A cross-sectional survey design was used in the study. In the study, a sample of 162 individuals was chosen at random from the student body. Both the independent and dependent variables were measured with three standardized tools. The use of multiple regression analysis was used to formulate and test two hypotheses. However, the researchers discovered that students' thoughts of being persecuted were jointly and significantly predicted by both hell anxiety and demonic conflict (F = 4.598, p=0.013, R2 = 0.105, r=0.325). Individually, that demonic struggle had significant contributions to the prediction of persecutory ideation. (R2= 0.342, t=2.844; P < 0.05). Hell, anxiety did not significantly predict persecutory ideation. (R2= -0.043, t=-0.360; P > 0.05). These findings recommended that religious authorities consider. minimizing satanic and hell themes in their sermon and focusing on angels, heaven, forgiveness, and other positive concepts that promote a favorable perspective of God, thereby improving the mental health of its congregation. Additionally, psycho-spiritual therapy on the guidance of one's life by good supernatural beings like angels may assist in lessening religiously insured persecutory thinking.
PERAN BALAI LATIHAN KERJA KOMUNITAS DALAM MENINGKATKAN KETERAMPILAN SANTRI DI BIDANG DESAIN GRAFIS
Authors: Fajri Ahmad  , Dion Pratama Putra  
Published: January 2024

Penelitian ini membahas Peran Balai Latihan Kerja Komunitas (BLKK) dalam Meningkatkan Keterampilan Santri di Bidang Desain Grafis Studi BLKK di Pondok Pesantren Kabupaten Agam. BLKK Pondok Pesantren di Agam dimulai pembangunannya 2019 dan dioperasikan tahun 2021 yaitu BLK Komunitas Pondok Pesantren Darul Makmur Baso dan BLK Komunitas Pondok Pesantren Tarusan Kamang. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi lapangan yang bertujuan untuk mengetahui Peran Balai Latihan Kerja Komunitas di Pondok Pesantren di Kabupaten Agam dalam Meningkatkan Keterampilan Santri di Bidang Desan Grafis.
Hasil dalam penelitian ini mengungkapkan bahwa Peran Balai Latihan Kerja Komuniats di Kabupaten Agam dapat meningkatkan keterampilan santri di bidang desain grafis melalui beberapa kegiatan melalui pembelajaran yaitu : Microsoft sebagai dasar untuk operasional computer bagi santri di BLK Komunitas di Pondok Pesantren Kabupaten Agam, santri dibekali penguasaan Microsoft Word, Power Point dan Exel. Kemudian mempelajari aplikasi corelDRAW untuk desain grafis, santri diberikan materi langsung dengan praktek membuat gambar sesuai dengan pembelajaran yang di terapkan di BLK komunitas mulai dari menetapkan suatu produk, filosofi suatu produk. Kegiatan pelatihan yang dilakukan oleh santri di BLK Komunitas Pondok Pesantren di Kabupaten Agam mendapatkan respon yang positif dengan antusias peserta pelatihan.
PROBLEMATIKA NARKOTIKA KALANGAN GENERASI MUDA DI KABUPATEN SINJAI
Authors: Mudjrimin Jusri , Azhar Nur Muhammad 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui permasalahan (problematika) yang saat ini menggerogoti dan menghantui generasi masa depan bangsa. Problematika ini tak lain dan tak bukan ialah narkoba. Kehadiran narkoba sudah menjadi momok yang menakutkan bagi para generasi bangsa. Kehadirannya tidak hanya merusak fisik, akan tetapi juga merusak psikis dan mental generasi bangsa. Bahaya bagi para pengonsumsi narkoba sudah menjadi rahasia umum. Bahkan pemerintah di Indonesia memberikan aturan hukum tersendiri bagi pengedar dan pengonsumsi narkoba. Lantas bagaimana proses adaptasi narkoba hingga dapat menjangkiti generasi muda sekarang? Sehingga mampu menjadi ancaman terbesar bagi para generasi muda. Hal paling penting dalam penelitian ini adalah langkah yang harus diambil untuk menghadapi penyalahgunaan narkoba yang saat ini menyerang generasi muda bangsa. Sejauh ini, pihak BNN sudah membentuk Badan Nasional Kabupaten berdasarkan Peraturan Presiden Nomor 23 Tahun 2010 yang memiliki tugas membantu tugas Badan Narkotika Nasional di tingkat kabupaten. Selain itu, Tak bisa dipungkiri peran keluarga, aparat negara, serta seluruh lapisan masyarakat turut serta memiliki andil dalam hal pencegahan dan penanggulangan narkoba
Development of Chromatographic Profile of Processed and non-processed Piper nigrum Linn.
Authors: Wanjari Anita , Rathi Bharat , Sonare Makrand , Wanjari Dinesh S , Wankhede Sukeshini 
Published: January 2024

Advanced Chromatographic technique is one of the parameters for qualitative and quantitative assessment. In this study advanced chromatographic studies were conducted for the assessment of processed and non-processed Piper nigrum Linn. Ayurvedic pharmaceutical is enriched in a wide range of preparations. The specific methods are applied for different formulation preparations. Laghumaini vasant is a herbomineral formulation in which one of the ingredients is P. nigrum. In this formulation, the special process is advocated for P.nigrum.Linn. P nigrum should be soaked in buttermilk till the outer black covering is removed. There are possibilities that some changes may occur due to this process. Hence this study focused on the comparative assessment of processed P. nigrum and non-processed P.nigrum. For assessment chromatography techniques were used. HPLC and HPTLC methods were used to get more precise results. High-Performance Thin Layer and High performance Liquid Chromatography were studied by using piperine as a reference standard. The piperine bands were seen in both processed and non-processed P.nigrum when analysed through both techniques. But, HPLC method has shown that piperine recovery is more in processed P.nigrum. In non-processed P.nigrum twenty seven peaks were observed but after processing with Buttermilk twenty one peaks were seen. The small six peaks were missing in processed P.nigrum.
Wound Healing Potential of Different Extracts of Ehretia Laevis Roxb. (Khandu Chakka/Ajan Vruksha) Versus Silver Sulfadiazine in Burn Wound - Pre-Clinical Study
Authors: Thakre Rushikesh , Borkar Preeti , Harne Ketaki 
Published: January 2024

Burns are also a leading cause of morbidity; millions who survive suffer from lifelong disability and disfigurements with resulting emotional trauma and stigma. To identify the effective extract of Charma Vruksha( Ehretia Laveis Roxb.) in burn wound management and to generate empirical evidence for substantiation of burn wound healing by Kashaya Rasa ( Astringent taste) through experimental demonstration of the comparative wound healing property of Charma Vruksha ( Ehretia Laevis Roxb.) this study was planned. This study is useful in broadening of therapeutic aspect of Charma Vruksha( Ehretia Laveis Roxb.) plant. This is contribution to the literature related to ayurvedic sciences. The stated side effects of silver sulfadiazine like pain, burning, itching, rash, cell death, destruction of red blood cells (in patients with G6PD deficiency), deficiency of granulocytes in the blood, low blood platelet count, low white blood cell count , can be minimized to some extent by the use of Charma Vruksha( Ehretia Laveis Roxb.) plant leaves. Wound healing measured by histology score and wound contracture percentages. Average wound contracture percentage was 36.83 % in Crude Extract group, 33.75% in Ethanol Extract group, 34.6 % in Chloroform Extract group , 42.41% in Aqueous Extract group, as compared to 38.08 % of Silver sulfadiazine. Histological score was 16 in Crude Extract group, 15 in Ethanol Extract group,15 in Chloroform Extract group , 16 in Aqueous Extract group as compared to 18 of Silver sulfadiazine. Aqueous Extract was more effective in burn wound contracture by 11.37 % than Silver sulfadiazine Crude and Aqueous extract was more effective than ethanol and chloroform extract by 1 histological score but less effective by 2 histological score than Silver sulfadiazine.
Aqueous Extract is more efficacious in burn wound contracture by 11.37 % than Silver sulfadiazine.
Job pressures affecting the quality of teachers’ performance at the College of Physical Education and Sports Sciences/University of Baghdad
Authors: Salah Wahhab Shakir  , Magda Abdel-Ilah Abdel-Sattar  , Thaker Mahfoodh Hamed al- Dulaimi  
Published: January 2024

The research aimed to prepare a measure of job stressors affecting the quality of teaching performance in the College of Physical Education and Sports Sciences at the University of Baghdad, to identify their levels, if any, and the most influential dimensions on the quality of teaching performance within the college’s work environment, as well as the deanship’s ability to help prevent and Alleviating its severity through logical administrative methods, on a scale that includes four dimensions that include (the administrative and financial environment, the organizational environment, the social and humanitarian environment, and the scientific and research environment). The descriptive approach was adopted using the case study method for a sample of (166) teachers from the original community of (182) teachers, with a percentage of (91.209%). The research results were processed using the statistical package system (SPSS), version (V28), (statistical package for social sciences). The results showed that teachers were exposed to pressures from the social and humanitarian environment in the first place, followed by pressures from the scientific and research environment, then the organizational environment, and pressures from the administrative and financial environment, respectively, at varying levels. Which enabled us to conclude that there is ambiguity in tasks, roles, and overlapping work, in addition to the need to assign higher administrative levels and their moral and material support, and the college deanship can help in ensuring prevention and alleviating the severity of the pressures that teachers are exposed to in the dimensions and All functional environment. The most important recommendations that came out of the study emphasize giving priority and attention to teachers as a supreme value in the College of Physical Education and Sports Sciences, in addition to consolidating human relations and social connections and solving problems between colleagues in general, and teachers and students in particular, and ensuring the requirements for the success of quality Moral and material performance for teachers, in addition to all entitlements.
HUMAN CAPITAL AS A FACTOR OF INTENSIVE DEVELOPMENT OF THE DIGITAL ECONOMY
Authors: Какizhanova Т. , Andabayeva G. 
Published: January 2024

Currently, the development of digital technologies and their dissemination is one of the phenomena accepted by the development of society as a whole, it has a significant impact on the sustainable development of the country's economy, and we must take full advantage of its opportunities for economic development. The development of digital technologies is the basis for the development of the digital economy. But the further development of digital technologies is closely related to human capital, which requires increased investment in its development.The article notes that human capital is one of the main factors influencing the development of digital technologies and the development of the digital economy as a whole. Human capital can play the role of a driving force behind the rapid and at the same time sustainable development of the country’s economy in the digital economy. Therefore, it is necessary to pay special attention to the growth of human capital. To this end, the article aims to study the interdependence of human capital and the development processes of the digital economy. In the course of studying this relationship, an original system of indicators was created, econometric models of the development of human capital and the digital economy in the Republic of Kazakhstan were created. In addition, the authors tested the hypothesis about the strengthening of the processes of economic growth and human capital development, which are interconnected with the processes of development of the digital economy.
LITTLE-KNOWN PHOTOS OF MUKHAMEDZHAN TYNYSHPAEV AND MUSTAFA SHOKAYA
Authors: Iskhakov S. 
Published: January 2024

The study of political sobriety, honesty, and discontent of a certain population is one of the main problems in the world. In this case, a certain policy towards the masses is important. Currently, contradictory ideas about the national policy pursued in the Russian Empire at the beginning of the twentieth century have been formed in political vocabulary and historiography. In this empire, known as the Orthodox Christian state, national policy was reduced to regulating not the Position of non-Russian ethnic groups, but the status of their confessions and the organization of this social life, partially determined by local religious institutions, according to the imperial vocabulary, "foreigners".The only subject of such a "national" policy was the imperial center, and the non-Russian peoples remained only the object of "national" management aimed at turning all territories annexed to Central Russia by the non-Russian population into a single all-Russian society. In practice, this meant that the policy of integrating violence turned into various variants of the "civilized" policy of Christianization and Russification, but such efforts did not yield the expected results.This article is devoted to three photographs that allow us to expand our understanding of the political biography of two prominent representatives of the Kazakh people -Mukhamedzhan Tynyshpaev and Mustafa Shokai, who played a major role in the struggle of the peoples of Central Asia for self-determination in the early twentieth century.
Gold-arsenic sulfide mineralization of the Kayancha area, Gorny Altai
Authors: Kryazhev Sergey , Dvurechenskaya Svetlana , Okulov Aleksey , Fedak Stepan 
Published: January 2024

Gold-arsenic sulfide type mineralization has first been revealed for the Gorny Altai region. The mineralized zones associate with lamprophyre dikes and are controlled by steeply dipping faults transecting the Vendian-Cambrian terrigenous-carbonate-volcanogenic sequence. The ore bodies are localized in horizons of basic metavolcanic rocks, enclosed between limestone layers. The near-ore metasomatites are composed of the paragenesis of albite, magnesiosiderite, and sericite. The gold content is related to fine dissemination of arsenic pyrite and arsenopyrite. Gold in the primary and oxidized ores is
submicroscopic and finely dispersed. The sulfur isotopic composition of the sulfides (δ34SCDT = 0 ‰) indicates an association of the mineralization with a deep-seated magmatic source. The Kokpatas gold deposit in western Uzbekistan is considered as an analogue.
Past anthropogenic land use change caused a regime shift of the fluvial response to Holocene climate change in the Chinese Loess Plateau
Authors: Chen Hao , Wang Xianyan , Yu Yanyan , Lu Huayu , Van Balen Ronald 
Published: January 2024

Abstract. The Wei River catchment in the southern part of the Chinese Loess Plateau (CLP) is one of the centers of the agricultural revolution in China. The area has experienced intense land use changes since ∼6000 BCE, which makes it an ideal place to study the response of fluvial systems to past anthropogenic land cover change (ALCC). We apply a numerical landscape evolution model that combines the Landlab landscape evolution model with an evapotranspiration model to investigate the direct and indirect effects of ALCC on hydrological and morphological processes in the Wei River catchment since the mid-Holocene. The results show that ALCC has not only led to changes in discharge and sediment load in the catchment but also affected their sensitivity to climate change. When the proportion of agricultural land area exceeded 50 % (around 1000 BCE), the sensitivity of discharge and sediment yield to climate change increased abruptly indicating a regime change in the fluvial catchment. This was associated with a large sediment pulse in the lower reaches. The model simulation results also show a link between human settlement, ALCC and floodplain development: changes in agricultural land use led to downstream sediment accumulation and floodplain development, which in turn resulted in further spatial expansion of agriculture and human settlement.
Stress Levels and Coping Strategies in Medical Students and its Association with Salivary IL-6 Levels
Authors: Karanth Monica , Shenoy Basti Anahita R , Chandralekha N  , Reberio Cleeta 
Published: January 2024

BACKGROUND: Medical students experience stress throughout their training period, to which they have built their own coping mechanisms. Stress alters various physiological processes, including markers like IL-6, a pro-inflammatory marker. The present study was conducted to assess the stress levels and coping strategies in medical students and its association with salivary IL-6 levels.
METHODS: This descriptive study was conducted after obtaining institutional ethical clearance. Total of 76 undergraduate medical students who gave their consent, answered the Cohen’s perceived stress scale and BriefCOPE questionnaire. Unstimulated saliva was used to assess salivary IL-6 levels using Diaclone human IL-6 ELISA kit and data obtained was analyzed.
RESULTS: Out of the 76 participants, 59(77.6%) were females and 17(22.4%) were males. Mild stress was perceived by 9 students, moderate and severe stress by 53 and 14 students respectively. Based on Kruskal-Wallis p test, in all grades of stress, approach method of coping had a higher score. Approach is form of active coping strategy where the students deal with the stressor in order to solve the issue and plan for the future. Approach coping has shown better responses for adversity, physical health and emotional responsiveness. Most commonly used coping strategies in mild and medium stress was acceptance, positive-refrain and planning. Students with severe stress adopted planning, self-distraction and self-blame. In spite of the perceived stress, there was no significant difference in the salivary IL-6 levels among the three categories.
CONCLUSION: The common coping strategies employed by students to handle stress was ‘approach’. As described in the BriefCOPE, it has been shown to be associated with better outcomes. In spite of this, a vast number of students have reported to experience stress. Therefore, more effective coping strategies are needed to handle stress and demands of the profession. The study also emphasizes on need for further research with a large sample size to assess the relation between salivary IL-6 and stress levels.