bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doppler ultrasonographic evaluation of tissue revascularization following connective tissue graft at implant sites
Authors: Tavelli Lorenzo , Kripfgans Oliver D. , Chan Hsun‐Liang , Vera Rodriguez Maria , Sabri Hamoun , Mancini Leonardo , Wang Hom‐Lay , Giannobile William V. , Barootchi Shayan 
Published: October 2023

AbstractAimTo assess the Doppler ultrasonographic tissue perfusion at dental implant sites augmented with connective tissue graft (CTG) using coronally advanced flap (CAF) or tunnel technique (TUN).Materials and MethodsTwenty‐eight patients presenting with isolated healthy peri‐implant soft‐tissue dehiscence (PSTD) were included in this randomized clinical trial. PSTDs were treated with either CAF + CTG or TUN + CTG. Ultrasound scans were taken at baseline, 1 week, 1 month, 6 months and 12 months. Tissue perfusion at the mid‐facial, mesial and distal aspects of the implant sites was assessed by colour Doppler velocity (CDV) and power Doppler imaging (PDI). Early vascularization of the graft and the flap at 1 week and at 1 month were evaluated via dynamic tissue perfusion measurements (DTPMs), including flow intensity (FI), mean perfusion relief intensity (pRI) and mean perfused area (pA).ResultsRegression analysis did not reveal significant differences in terms of mid‐facial CDV and PDI changes between CAF and TUN over 12 months (p > .05), while significant differences between the two groups were observed at the interproximal areas (p < .001 for both CDV and PDI changes). Higher early DTPMs were observed at the TUN‐treated sites in terms of mean FI of the graft (p = .027) and mean FI (p = .024) and pRI of the flap (p = .031) compared with CAF‐treated sites at 1 week. Assessment of the FI direction showed that CTG perfusion at 1 week and at 1 month mainly occurred from the flap towards the implant/bone. Early tissue perfusion outcomes were found to be associated with the 12‐month mean PSTD coverage and mucosal thickness gain.ConclusionsDoppler ultrasonography shows tissue perfusion changes occurring at implant sites augmented with CTG. The main differences in tissue perfusion between CAF and TUN were observed at the interproximal sites, with early perfusion associated with clinical and volumetric outcomes at 12 months.
Practitioner Review: Effectiveness and mechanisms of change in participatory arts‐based programmes for promoting youth mental health and well‐being – a systematic review
Authors: Williams Emma , Glew Sarah , Newman Hannah , Kapka Agneiska , Shaughnessy Nicola , Herbert Ruth , Walduck Jackie , Foster Annette , Cooke Paul , Pethybridge Ruth , Shaughnessy Caitlin , Hugh‐Jones Siobhan 
Published: October 2023

BackgroundParticipatory arts‐based (PAB) programmes refer to a diverse range of community programmes involving active engagement in the creation process that appear helpful to several aspects of children's and young people's (CYP) mental health and well‐being. This mixed‐methods systematic review synthesises evidence relating to the effectiveness and mechanisms of change in PAB programmes for youth.MethodStudies were identified following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses approach. Eleven electronic databases were searched for studies of PAB programmes conducted with CYP (aged 4–25 years), which reported mental health and well‐being effectiveness outcomes and/or mechanisms of change. A mixed‐methods appraisal tool assessed study quality. A narrative synthesis was conducted of effectiveness and challenges in capturing this. Findings relating to reported mechanisms of change were integrated via a metasummary.ResultsTwenty‐two studies were included. Evidence of effectiveness from quantitative studies was limited by methodological issues. The metasummary identified mechanisms of change resonant with those proposed in talking therapies. Additionally, PAB programmes appear beneficial to CYP by fostering a therapeutic space characterised by subverting restrictive social rules, communitas that is not perceived as coercive, and inviting play and embodied understanding.ConclusionsThere is good evidence that there are therapeutic processes in PAB programmes. There is a need for more transdisciplinary work to increase understanding of context–mechanism–outcome pathways, including the role played by different art stimuli and practices. Going forward, transdisciplinary teams are needed to quantify short‐ and long‐term mental health and well‐being outcomes and to investigate optimal programme durations in relation to population and need. Such teams would also be best placed to work on resolving inter‐disciplinary methodological tensions.
Chroma‐dependence of CIEDE2000 acceptability thresholds for dentistry
Authors: Tejada‐Casado Maria , Pérez María M. , Della Bona Alvaro , Lübbe Henning , Ghinea Razvan , Herrera Luis Javier 
Published: October 2023

AbstractObjectivesDetermine visual 50:50% color difference acceptability thresholds (AT) for regions of the dental color space with varying chromaticity.MethodsA 40‐observer panel belonging to two different groups (dentists and laypersons) evaluated 144 dental resin composites pairs (divided in three different sets of 48 pairs according to chroma value: Low Chroma (LC), Medium Chroma (MC) and High Chroma (HC) placed 40 cm away and inside of a viewing cabinet (D65 Standard light source; diffuse/0° geometry). A Takagi–Sugeno–Kang (TSK) fuzzy approximation was used for fitting the data points and calculate the 50:50% acceptability thresholds in CIEDE2000. A paired t‐test was used to evaluate the statistical significance between thresholds differences and Bonferroni correction was applied.ResultsThe CIEDE2000 50:50% AT were ∆E00 = 2.84, ∆E00 = 2.31 and ∆E00 = 1.80 for LC, MC and HC sets of sample pairs, respectively. The 50:50% AT values were statistically significant between the different sets of sample pairs, as well as the 50:50% AT values obtained for different observer groups.Conclusions50:50% CIEDE2000 acceptability thresholds for dentistry are significantly different depending on the chromaticity of the samples. Observers show higher acceptability for more achromatic samples (low chroma value) than for more chromatic samples.Clinical SignificanceThe difference in the AT for distinct regions of the dental color space can assist professionals as a quality control tool to assess clinical performance and interpret visual and instrumental findings in clinical dentistry, dental research, and subsequent standardization processes.
Human immunodeficiency virus diagnosis and care among adults with intellectual and developmental disabilities who are publicly insured
Authors: James T. G. , Argenyi M. S. , Gravino A. , Benevides T. W. 
Published: October 2023

AbstractBackgroundThis study aimed to assess the prevalence of human immunodeficiency virus (HIV) testing, HIV diagnosis and receipt of HIV care among adults with intellectual and developmental disabilities (IDDs) who are publicly insured in the USA.DesignThis study is a cross‐sectional analysis of Medicare–Medicaid linked data of adults with IDD who were publicly insured in 2012 (n = 878 186).MethodsWe estimated adjusted prevalence ratios of HIV testing, diagnosis and receipt of antiretroviral therapy (ART). We also identified the relationship between predisposing (age, gender, race and ethnicity), enabling (Medicare, Medicaid or both; rural status; geographical location; and county income) and need‐related characteristics (IDD diagnosis and other co‐occurring conditions) associated with these outcomes.ResultsOnly 0.12% of adults with IDD who had no known HIV diagnosis had received an HIV test in the past year. The prevalence of HIV diagnosis among adults with IDD was 0.38%, although differences by type of IDD diagnosis were observed. Prevalence of HIV diagnosis differed by type of IDD. Among adults with IDD who were living with HIV, approximately 71% had received ART during 2012. The adjusted analyses indicate significant racial disparities, with Black adults with IDD making up the majority (59.11%) of the HIV‐positive IDD adult population.ConclusionsAdults with IDD are a unique priority population at risk for HIV‐related disparities, and the level of risk is differential among subtypes of IDD. People with IDD, like other people with disabilities, should be considered in prevention programming and treatment guidelines to address disparities across the HIV care continuum.
Bilirubin impacts microglial autophagy via the Akt–mTOR signaling pathway
Authors: Li Ling , Li Siyu , Pan Zhifan , Zhang Yan , Hua Ziyu 
Published: October 2023

AbstractBilirubin encephalopathy is a severe complication of neonatal hyperbilirubinemia. With elevation of serum unconjugated bilirubin (UCB) levels, UCB crosses the blood–brain barrier and possibly leads to neurological dysfunction. Neuroinflammation is recognized as a prominent pathological feature in bilirubin encephalopathy. Recent studies have suggested that autophagy plays a crucial role in the inflammatory response. However, the potential effect of microglial autophagy in the pathogenesis of bilirubin encephalopathy remains uncertain. The in vitro findings verified that in primary cultured microglia, UCB significantly reduced the ratio of LC3B‐II to LC3B‐I and downregulated the expression of ATG5, Beclin‐1, and ATG7, while increasing the expression of p62/SQSTM1. The results showed that UCB could decrease the number of mCherry‐EGFP‐LC3 positive puncta, even when chloroquine (CQ) was applied to block the microglial autophagy flux. Mechanistically, UCB was found to upregulate the expression of TLR4 and increase the phosphorylation levels of Akt and mammalian target of rapamycin (mTOR). Promoting microglial autophagy by treatment with Rapamycin (RAPA), an mTOR inhibitor, decreased the levels of NOD‐like receptor protein 3 (NLRP3) inflammasome components and IL‐1β, rescued microglial overactivation, and improved neurological functions. These data indicated that UCB could impact microglial autophagy via the Akt–mTOR signaling pathway and synergistically promote neuroinflammatory responses. Enhancing autophagy might disrupt the assembly of NLRP3 inflammasome, attenuate UCB‐induced neuroinflammation, and improve the prognosis of model rats with bilirubin encephalopathy. In conclusion, this study implies that regulating microglial autophagy might be a promising therapeutic strategy for bilirubin encephalopathy.image
Counter‐hegemonic sport: Constructing alternative sports narratives in Indian cinema
Authors: Jha Sonal 
Published: October 2023

AbstractThis paper explores the Indian sports film as a category that gains popularity after the economic reforms of the 1990s. Influenced by the Hollywood sports film and global neoliberal ideals, these films incorporate local ideological influences and contribute to the prevailing discourse about sport in India. While mainstream films convey dominant values associated with sport, there are films which challenge these notions. This study examines two such films, Mukkabaaz (2017) and Sudani from Nigeria (2018), which carry subversive potential against hegemonic conceptions of individual, community, nation and merit, and offer an alternate understanding of sport and its role in society.
Pharmacokinetics and pharmacodynamics of intranasal and intramuscular administration of naloxone in working dogs administered fentanyl
Authors: Barr Ciara A. , Haughan Joanne , Gianotti Giacomo , Varner Kelley , Drobatz Kenneth J. , Stefanovski Darko , Robinson Mary , Pennington Mark , McGuire Amanda , Otto Cynthia M. 
Published: October 2023

AbstractBackgroundWorking dogs exposed to narcotics might require reversal in the field.ObjectiveTo explore the pharmacokinetic and pharmacodynamic effects of naloxone administered intramuscularly (IM) or intranasally (IN) to reverse fentanyl sedation in working dogs.AnimalsTen healthy, working dogs aged 1.7 ± 1 year and weighing 26 ± 3 kg.MethodsIn this randomized, controlled cross‐over study dogs received either 4 mg of naloxone IN or IM 10 minutes after fentanyl (0.3 mg IV) administration. Sedation was assessed at baseline and 5 minutes after fentanyl administration, then at 5, 10, 15, 20, 25, 30, 60 and 120 minutes after reversal with naloxone. Blood samples for naloxone detection were obtained at 0, 5, 10, 30, 60 and 120 minutes. Pharmacokinetic parameters and sedation scores were compared between IM and IN naloxone groups.ResultsThere was a significant increase in sedation score from baseline (0.25 [−4 to 1] IM; 0 [−2 to 1] IN) after fentanyl administration (11 [5‐12] IM; 9.25 [4‐11] IN), followed by a significant reduction at 5 (0.5 [−0.5 to 1.5] IM; 1.25 [−1.5 to 4.5] IN) through 120 minutes (−0.5 [−2 to 1] IM; 0 [−4.5 to 1] IN) after reversal with naloxone. Route of administration had no significant effect on sedation score. Maximum plasma concentration was significantly lower after IN administration (11.7 [2.8‐18.8] ng/mL IN, 36.7 [22.1‐56.4] ng/mL IM, P < .001) but time to reach maximum plasma concentration was not significantly different from IM administration.Conclusion and Clinical ImportanceAlthough IM administration resulted in higher naloxone plasma concentrations compared to IN, reversal of sedation was achieved via both routes after administration of therapeutic doses of fentanyl.
Volume electron microscopy reconstruction uncovers a physical barrier that limits virus to phloem
Authors: Lv Mingfang , Dai Yuanxing , Xie Li , Guo Jiansheng , Liao Zhenfeng , Shang Weina , Zhao Xiaohuan , Hong Jian , Zhang Heng‐Mu 
Published: October 2023

Summary
Most plant reoviruses are phloem‐limited, but the mechanism has remained unknown for more than half a century. Southern rice black‐streaked dwarf virus (Fijivirus, Reoviridae) causes phloem‐derived tumors, where its virions, genomes, and proteins accumulate, and it was used as a model to explore how its host plant limits the virus within its phloem.
High‐throughput volume electron microscopy revealed that only sieve plate pores and flexible gateways rather than plasmodesmata had a sufficiently large size exclusion limit (SEL) to accommodate virions and potentially serve as pathways of virion movement.
The large SEL gateways were enriched within the proliferated sieve element (SE) layers of tumors. The lack of such connections out of the SE‐enriched regions of tumors defined a size‐dependent physical barrier to high flux transportation of virions.
A working model is proposed to demonstrate the mechanism underlying limitation of virus within phloem.
Estimating leaf day respiration from conventional gas exchange measurements
Authors: Yin Xinyou , Amthor Jeffrey S. 
Published: October 2023

SummaryLeaf day respiration (Rd) strongly influences carbon‐use efficiencies of whole plants and the global terrestrial biosphere. It has long been thought that Rd is slower than respiration in the dark at a given temperature, but measuring Rd by gas exchange remains a challenge because leaves in the light are also photosynthesizing. The Kok method and the Laisk method are widely used to estimate Rd. We highlight theoretical limitations of these popular methods, and recent progress toward their improvement by using additional information from chlorophyll fluorescence and by accounting for the photosynthetic reassimilation of respired CO2. The latest evidence for daytime CO2 and energy release from the oxidative pentose phosphate pathway in chloroplasts appears to be important to understanding Rd.
Intersections of teacher noticing and culturally sustaining pedagogy:Aconceptual framework to inform the design of teacher learning
Authors: Luna Melissa J. , Bernstein Malayna , Walkoe Janet D. K. 
Published: October 2023

AbstractTeacher noticing scholars are just beginning to explore how to support noticing that is responsive to students' cultural resources. The theoretical basis of the teacher noticing literature affords scholars a range of paths for understanding student resources, only some of which are described in the literature. In this article, we offer a conceptual model showing how the theoretical roots related to teacher noticing and responsive teaching (N/RT) are closely aligned with theories foundational to culturally sustaining pedagogy (CSP). We then offer an illustration of teachers participating in a video club specifically designed to support noticing students' disciplinary thinking in science—and show how the teachers' talk positioned them to see the cultural foundations of student learning, a perspective that lays the groundwork for teachers to teach in culturally sustaining ways. With an eye to developing future designs of video clubs that highlight disciplinary thinking in both mathematics and science alongside cultural resources—and the intersections therein—in this article, we begin the foundational work of better understanding the theoretical connections across both cultural and disciplinary ways of seeing, knowing, and responding.
Iron supplementation: A qualitative study on the perception of blood donors, blood collection staff and donor physicians
Authors: Karregat Jan H. M. , Blokhuis Dayna , Quee Franke A. , van den Hurk Katja 
Published: October 2023

AbstractBackground and ObjectivesIron supplementation is an effective strategy to mitigate donation‐induced iron deficiency in blood donors. However, evidence on the perception of individuals involved in blood donation on iron supplementation as a blood service policy is lacking. This study aimed to evaluate the knowledge and perception of whole blood donors (donors), blood collection staff (collection staff) and donor physicians (physicians) regarding donation‐induced iron loss and iron supplementation.Materials and MethodsOnline focus group discussions had four to six participants and followed a structured questioning approach. All participants had to be fluent in Dutch to participate, and donors had donated at least five times. Sixteen donors, eight collection staff members and four physicians participated in this study. Recordings were transcribed, coded and analysed using a grounded theory approach.ResultsAwareness of donation‐induced iron loss was limited in donors. Donors and physicians were predominantly positive towards iron supplementation; the primary motivator for donors was to prevent deferral and reduce iron‐deficiency‐related symptoms. Improving donor health was the main argument for physicians to advocate iron supplementation. Staff had a critical view on iron supplementation as a policy, as they perceived it as unethical and possibly ineffective. A knowledge gap might underlie their concerns.ConclusionMost individuals involved in blood donation are positive towards iron supplementation as a blood service policy. If implemented, guidance and monitoring is desired and adequate education of all stakeholders is required.
CFD ANALYSIS OF EROSION RATE IN OIL AND GAS PIPELINE INDUSTRY
Authors: Ali Othman Nur Tantiyani , Adi Putra Zulfan , Zainal Abidin Shahrul Azman , M Ali Fadzrul Izwan 
Published: October 2023

Generally, crude oil has been transported via pipelines. But sand particles normally will be deposited on the bottom of pipeline due to the unsteady flow which it can lead to flow concern and erosion deformation of the pipe wall if not well treated. As well, this issue can cause the pipe destruction and burden the maintenance cost if not prevented in the early stage. Thus, this study was simulated to observe and predict the erosion rate at various parameter conditions with presence of solid particles in pipeline surface via COMSOL© Multiphysics 5.4 software. The model of k-ω turbulent and particle tracing were applied where several different potential impacting factors on the formation of erosion were investigated including fluids flow velocity, sand particle size, sand flow rates, pipe orientation and pipe diameter. The result simulation showed the area around the bend pipe had high predictions of erosion deformation where the maximum erosion rate of 732 mg/m2s was observed for 2-inch pipe diameter and 100mm particle size. Besides, it shows the erosion rate increased as the higher mass flow rate and fluid velocity. By applying these erosion models, it could be possible to foresee the maximum point of erosion deformation along the pipelines which can reduce maintenance cost and prevent flow assurance issues.
Apéry extensions
Authors: Golyshev Vasily , Kerr Matt , Sasaki Tokio 
Published: October 2023

AbstractThe Apéry numbers of Fano varieties are asymptotic invariants of their quantum differential equations. In this paper, we initiate a program to exhibit these invariants as (mirror to) limiting extension classes of higher cycles on the associated Landau–Ginzburg (LG) models — and thus, in particular, as periods. We also construct an Apéry motive, whose mixed Hodge structure is shown, as an application of the decomposition theorem, to contain the limiting extension classes in question. Using a new technical result on the inhomogeneous Picard–Fuchs equations satisfied by higher normal functions, we illustrate this proposal with detailed calculations for LG‐models mirror to several Fano threefolds. By describing the “elementary” Apéry numbers in terms of regulators of higher cycles (i.e., algebraic ‐theory/motivic cohomology classes), we obtain a satisfying explanation of their arithmetic properties. Indeed, in each case, the LG‐models are modular families of surfaces, and the distinction between multiples of and (or ) translates ultimately into one between algebraic and of the family.
Lithium Battery Thermal Management Based on Lightweight Stepped-Channel Liquid Cooling
Authors: Zhou Long , Li Shengnan , Jain Ankur , Chen Guoqiang , Guo Desui , Kang Jincan , Zhao Yong 
Published: October 2023

Abstract
This study proposes a stepped-channel liquid-cooled battery thermal management system based on lightweight. The impact of channel width, cell-to-cell lateral spacing, contact height, and contact angle on the effectiveness of the thermal control system (TCS) is investigated using numerical simulation. The weight sensitivity factor is adopted to evaluate the effect of TCS weight (mTCS) on the maximum temperature (Tmax) of battery pack. Results suggest that the channel width plays the most critical role, followed by cell-to-cell lateral spacing and contact angle, while the contact height has minimal influence. Four parameters that affect the thermal balance performance of battery pack, including the number of channels, and baffles, baffle angle, and coolant inlet velocity, are presented using orthogonal experiment. Results indicate that the number of channels and baffle angle have a significant influence on the thermal balance of battery pack, while thermal performance is largely insensitive to coolant inlet velocity and the number of baffles. Based on the analysis stated in this work, an improved design of the TCS is presented that reduces weight by 54.08% while increasing Tmax only by 2.52 K.