bluuebunny/crossref_metadata_2025_split huggingface dataset:
КОРЕКЦІЯ ГЕМАТОЛОГІЧНИХ ПОКАЗНИКІВ У ПАЦІЄНТІВ З ПОРТАЛЬНОЮ ГІПЕРТЕНЗІЄЮ
Authors: Тутченко М. І. , Чуб С. Л. , Рудик Д. В. , Іванчов П. В. 
Published: October 2023

РЕЗЮМЕ. Мета роботи – оцінка хірургічної тактики на покращення прогнозу виживання пацієнтів з ПГ, що ускладнена кровотечею із стравохідних вариксів, та виявлення гематологічних змін, як компенсаторного показника ПГ.
Матеріал і методи. Проаналізовано клінічний матеріал 34 пацієнтів з ПГ (середній вік – (49,09±1,65) року; 16 чоловіків, 18 жінок). Пацієнтів поділили на дві групи: перша група – 23 особи, яким усунення джерела кровотечі здійснювали шляхом лапароскопічної деваскуляризації проксимального відділу шлунка, абдомінального відділу стравоходу з наступною його транссекцією в епікардіальній ділянці; друга група – 11 пацієнтів, яким додатково виконували спленектомію.
Результати. Оцінку результатів проводили в найближчому періоді (14 діб). У першій групі виявлено збільшення рівня еритроцитів у першу добу після операції на 15,61 %, порівняно з вихідними показниками, зменшення на 11,25 % на третю добу порівняно з першою добою, і незначне підвищення на 0,72 % на одинадцяту добу, порівняно з третьою добою. В другій групі зафіксоване збільшення відповідно на 18,65 % в першу добу, зменшення на 1,31 % в третю добу і незначне зниження на 1 % до одинадцятої доби.
Динаміка лейкоцитозу мала хвилеподібний характер. У першу добу післяопераційного періоду рівень лейкоцитів зріс на 63,39 % у першій групі та на 80,56 % у другій групі, порівняно з вихідними показниками, на третю добу спостерігалось зниження на 13,34 % у першій та на 6,37 % у другій групі, порівняно з першою добою, на одинадцяту добу виявлено значне зниження лейкоцитозу на 46,67 % та 45,41 % відповідно.
Динаміка змін рівня тромбоцитів мала лінійну тенденцію до підвищення в обох групах. У першій групі підвищення не було значним: у першу добу на 3,1 %, на третю добу на 10,11 %, на одинадцяту добу на 2,49 %. У другій групі зафіксовано значне підвищення – 165,94 % в першу добу, 466,15 % на третю добу порівняно з першою добою та 177,76 % на одинадцяту добу в порівнянні з третьою добою, а в порівнянні з вихідним рівнем на 1374,95 %, тобто більш ніж в 13,5 раза.
Висновки. 1. Портальна гіпертензія призводить не тільки до суттєвих порушень у гемодинамічних показниках, у вигляді розширення вен, а й у гематологічних, які зумовлені як функціональними розладами з боку печінки, так і гіперспленізмом.

Виконання спленектомії в поєднанні із деваскуляризацією кардіального відділу шлунка та абдомінальної частини стравоходу та його апаратною транссекцією суттєво покращує гематологічні показники, і, як наслідок, зменшує кількість ускладнень та летальність.
One‐Year Outcomes and Their Relationship to Residual Mitral Regurgitation After Transcatheter Edge‐to‐Edge Repair With MitraClip Device: Insights From the OCEAN‐Mitral Registry
Authors: Kubo Shunsuke , Yamamoto Masanori , Saji Mike , Asami Masahiko , Enta Yusuke , Nakashima Masaki , Shirai Shinichi , Izumo Masaki , Mizuno Shingo , Watanabe Yusuke , Amaki Makoto , Kodama Kazuhisa , Yamaguchi Junichi , Nakajima Yoshifumi , Naganuma Toru , Bota Hiroki , Ohno Yohei , Yamawaki Masahiro , Ueno Hiroshi , Mizutani Kazuki , Adachi Yuya , Otsuka Toshiaki , Hayashida Kentaro , Hayashida Kentaro , Adachi Yuya , Yamamoto Masanori , Yamamoto Masanori , Shirai Shinichi , Watanabe Yusuke , Naganuma Toru , Yamawaki Masahiro , Enta Yusuke , Nakashima Masaki , Mizuno Shingo , Ueno Hiroshi , Ohno Yohei , Nakajima Yoshifumi , Izumo Masaki , Bota Hiroki , Kodama Kazuhisa , Yamaguchi Junichi , Kubo Shunsuke , Amaki Makoto , Asami Masahiko , Saji Mike , Mizutani Kazuki 
Published: October 2023

Background
Limited data are available about clinical outcomes and residual mitral regurgitation (MR) after transcatheter edge‐to‐edge repair in the large Asian‐Pacific cohort.

Methods and Results

From the Optimized Catheter Valvular Intervention (OCEAN‐Mitral) registry, a total of 2150 patients (primary cause of 34.6%) undergoing transcatheter edge‐to‐edge repair were analyzed and classified into 3 groups according to the residual MR severity at discharge: MR 0+/1+, 2+, and 3+/4+. The mortality and heart failure hospitalization rates at 1 year were 12.3% and 15.0%, respectively. Both MR and symptomatic improvement were sustained at 1 year with MR ≤2+ in 94.1% of patients and New York Heart Association functional class I/II in 95.0% of patients. Compared with residual MR 0+/1+ (20.4%) at discharge, both residual MR 2+ (30.2%;
P
< 0.001) and 3+/4+ (32.4%;
P
= 0.007) were associated with the higher incidence of death or heart failure hospitalization (adjusted hazard ratio [HR], 1.59;
P
< 0.001, and adjusted HR, 1.73;
P
= 0.008). New York Heart Association class III/IV at 1 year was more common in the MR 3+/4+ group (20.0%) than in the MR 0+/1+ (4.6%;
P
< 0.001) and MR 2+ (6.4%;
P
< 0.001) groups, and the proportion of New York Heart Association class I is significantly higher in the MR 1+ group (57.8%) than in the MR 2+ group (48.3%;
P
= 0.02).

Conclusions
The OCEAN‐Mitral registry demonstrated favorable clinical outcomes and sustained MR reduction at 1 year in patients undergoing transcatheter edge‐to‐edge repair. Both residual MR 2+ and 3+/4+ after transcatheter edge‐to‐edge repair at discharge were associated with worse clinical outcomes compared with residual MR 0+/1+.

Registration Information

https://upload.umin.ac.jp
. Identifier: UMIN000023653.
Reception and Makings of African Vocal Ensemble Sounds beyond Binaries
Authors: Moshugi Kgomotso 
Published: October 2023

Abstract
Since 1877, the Seventh-day Adventist (SDA) Church from North America has established its presence in Southern Africa. As with missionization in other denominations, this introduced a variety of primarily Euro-American musical influences into African religious practices. Over the years, Adventist musicians have constantly negotiated a complex relationship to their African contexts, often yielding musical outcomes that cannot be reduced simply to an indigenous vs exogenous or ‘African’ vs ‘Western’ binary evaluation. This intersectional phenomenon is not thoroughly explored in the current scholarship on SDA music. This paper provides background and details on collaborations and exchanges in various repertoires since the 1980s. I argue that these embody intersectional ideas that emerge beyond geographical, cultural, and chronological boundaries. The study is developed from analyzing unstructured interviews and audio recordings to illustrate perpetually blurred boundaries in musical practices that have conventionally distinguished “African” vocal sound.
Evaluation of morpho-physiological and biochemical indicators of salinity stress in Argemone mexicana L., medicinal plant from Papaveraceae
Authors: Unnikrishnan Sneha , Resmi Mohankumar Saraladevi , Mohan Gopika , Vivek Padmanabhan Jayanthikumari 
Published: October 2023

Abstract
Plant growth is significantly impacted by abiotic stress factors including soil salinity and plants do have different mechanism to nullify the effect of these stresses. The current study is to understand the various physio-biochemical characteristics of Mexican prickly poppy (Argemone mexicana L.), a medicinally valued species belongs to poppy family under different saline conditions (0 mM, 100 mM, 200 mM and 300 mM) to investigate the mechanisms underlying salinity tolerance. The results showed that salinity caused a negative impact on number of leaves, stomatal index and chlorophyll content in plants. Decreased chlorophyll content suggests a decline in photosynthetic rate. The concentrations of stress specific amino acid proline, soluble sugar sucrose, and secondary metabolite phenol were increased in plants treated with increasing concentrations of NaCl solution. Sucrose helps to protect the isolated chloroplast from damage caused by salinity stress. The degree of bleaching seen in the leaf disc assay was an indication of the damage caused by stress. These findings indicated that higher proline, sugar, and phenol content could be the key factors, which offer advantage to Argemone under saline conditions.
The complexity of multidisciplinary respiratory care in amyotrophic lateral sclerosis
Authors: Berlowitz David J. , Mathers Susan , Hutchinson Karen , Hogden Anne , Carey Kate A. , Graco Marnie , Whelan Brooke-Mai , Charania Salma , Steyn Frederik , Allcroft Peter , Crook Ashley , Sheers Nicole L. 
Published: October 2023

Motor neurone disease/amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no known cure, where death is usually secondary to progressive respiratory failure. Assisting people with ALS through their disease journey is complex and supported by clinics that provide comprehensive multidisciplinary care (MDC).
This review aims to apply both a respiratory and a complexity lens to the key roles and areas of practice within the MDC model in ALS. Models of noninvasive ventilation care, and considerations in the provision of palliative therapy, respiratory support, and speech and language therapy are discussed. The impact on people living with ALS of both inequitable funding models and the complexity of clinical care decisions are illustrated using case vignettes. Considerations of the impact of emerging antisense and gene modifying therapies on MDC challenges are also highlighted.
The review seeks to illustrate how MDC members contribute to collective decision-making in ALS, how the sum of the parts is greater than any individual care component or health professional, and that the MDC
per se
adds value to the person living with ALS. Through this approach we hope to support clinicians to navigate the space between what are minimum, guideline-driven, standards of care and what excellent, person-centred ALS care that fully embraces complexity could be.

Educational aims

To highlight the complexities surrounding respiratory care in ALS.

To alert clinicians to the risk that complexity of ALS care may modify the effectiveness of any specific, evidence-based therapy for ALS.

To describe the importance of person-centred care and shared decision-making in optimising care in ALS.
The effect of cognitive behavioral therapy on stress and anxiety of mothers of girls with precocious puberty symptoms: a randomized controlled trial
Authors: Rahimi Faranak , Mirghafourvand Mojgan , Farvareshi Mahmoud , Yavarikia Parisa 
Published: October 2023

Abstract
Introduction
: Precocious puberty in girls has been associated with an increased risk of stress and anxiety in their mothers. This study aimed to investigate the effect of cognitive behavioral therapy (CBT) on perceived stress and anxiety of mothers of girls with precocious puberty symptoms.

Methods
This randomized controlled trial was conducted on 70 mothers of girls with precocious puberty symptoms in Tabriz-Iran, 2021. The participants were randomly assigned to CBT and control groups through blocked randomization. Group counseling was provided to the intervention group in eight sessions of 45–60 min weekly with 5 to 7 women. A booklet containing explanations about puberty was provided for the both groups. Data were collected using the questionnaires of socio-demographic characteristics, Spielberger State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS) and quality of life (SF-36). Independent t-test, ANCOVA, chi-square, and fisher’s exact tests were used to compare the outcomes between the groups.

Findings
: After the intervention, based on ANCOVA test with adjusting the baseline values, mean scores of stress (mean difference (MD): -10.75; 95% confidence interval (95% CI): -11.77 to -9.72; P < 0.001), state anxiety (MD: -14.36; 95% CI: -15.7 to -12.7; P < 0.001) and trait anxiety (MD: -12.8; 95% CI: -14.4 to -11.1; P < 0.001) were significantly lower in CBT group compared to the control group. Also mean score of quality of life (MD: 9.82; 95% CI: -6.74 to -12.90; P < 0.001) was significantly higher in CBT group compared to the control group.

Conclusion
Based on the results, group CBT is effective in reducing stress and anxiety and improving the quality of life of mothers of girls with precocious puberty symptoms. However, more studies are required to make a definite conclusion in this field.

Trial registration
Iranian Registry of Clinical Trials (IRCT): IRCT20110826007418N6. Date of registration: 11/10/2021. URL: https://en.irct.ir/trial/57346; Date of first registration: 11/10/2021.
Depression among patients with chronic kidney disease, associated factors, and predictors: a cross-sectional study
Authors: Bahall Mandreker , Legall George , Lalla Carlyle 
Published: October 2023

Abstract
Background
Depression with diverse etiologies is exacerbated by chronic diseases, such as chronic kidney disease (CKD), coronary artery disease (CAD), cancer, diabetes mellitus, and hypertension. This study aimed to analyse depression, its associations, and predictors among patients attending the kidney clinic of a teaching hospital.

Methods
Data were collected from 01 August 2017 to 30 September 2017 via face-to-face interviews and examination of the medical records of a convenience sample of 314 patients. The patients were categorised broadly as stages I and II with an estimated glomerular filtration rate (eGFR) > 60 mls/min/1.73 m2, and with stages III, IV, and V or GFR ≤ 60 mls/ min/1.73 m2 (or CKD). The Patient Health Questionnaire (PHQ)-9 was the data collection instrument for depression-related data.

Results
Participants were predominantly male (n = 179; 57.0%), aged over 60 years (n = 211; 67.2%), Indo-Trinbagonian (n = 237; 75.5%), and with stages III, IV, and V CKD. The two leading comorbid conditions were hypertension (83.4%) and diabetes mellitus (56.1%). Of the 261 (83.1%) patients with recorded eGFR, 113 (43.3%) had Stage III CKD. The mean depression (PHQ-9) score was 13.0/27 ($$\pm$$9.15), with 306 (97.5%) patients diagnosed as having depression with the following severities: mild (n = 116; 37.9%), moderate (n = 138, 45.1%), moderately severe (n = 38; 12.4%), and severe (n = 14; 4.6%). Depression was independent of sex. Nine sociodemographic variables were associated with depression; however, ‘level of education’, was the only predictor of depression with greater severity associated with lower levels of education. eGFR was negatively correlated with the PHQ-9 scores (Pearson’s correlation, r = -0.144, p = 0.022). At least 78.3% of the patients who self-reported no depression had clinical depression (moderate, moderately severe, or severe) PHQ-9 scores ≥ 10.

Conclusion
Depression was a significant comorbidity among patients with CKD, with the majority displaying clinical depression. “Level of education” was the only predictor of depression. Self-reported depression is an unreliable method for evaluating clinical depression.
Development of a knowledge-based healthcare-associated infections surveillance system in China
Authors: Cao Yu , Niu Yaojun , Tian Xuetao , Peng DeZhong , Lu Li , Zhang Haojun 
Published: October 2023

Abstract
Background
In the modern era of antibiotics, healthcare-associated infections (HAIs) have emerged as a prominent and concerning health threat worldwide. Implementing an electronic surveillance system for healthcare-associated infections offers the potential to not only alleviate the manual workload of clinical physicians in surveillance and reporting but also enhance patient safety and the overall quality of medical care. Despite the widespread adoption of healthcare-associated infections surveillance systems in numerous hospitals across China, several challenges persist. These encompass incomplete coverage of all infection types in the surveillance, lack of clarity in the alerting results provided by the system, and discrepancies in sensitivity and specificity that fall short of practical expectations.

Methods
We design and develop a knowledge-based healthcare-associated infections surveillance system (KBHAIS) with the primary goal of supporting clinicians in their surveillance of HAIs. The system operates by automatically extracting infection factors from both structured and unstructured electronic health data. Each patient visit is represented as a tuple list, which is then processed by the rule engine within KBHAIS. As a result, the system generates comprehensive warning results, encompassing infection site, infection diagnoses, infection time, and infection probability. These knowledge rules utilized by the rule engine are derived from infection-related clinical guidelines and the collective expertise of domain experts.

Results
We develop and evaluate our KBHAIS on a dataset of 106,769 samples collected from 84,839 patients at Gansu Provincial Hospital in China. The experimental results reveal that the system achieves a sensitivity rate surpassing 0.83, offering compelling evidence of its effectiveness and reliability.

Conclusions
Our healthcare-associated infections surveillance system demonstrates its effectiveness in promptly alerting patients to healthcare-associated infections. Consequently, our system holds the potential to considerably diminish the occurrence of delayed and missed reporting of such infections, thereby bolstering patient safety and elevating the overall quality of healthcare delivery.
Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study
Authors: Gao Hui , Zheng Shuhao , Yuan Xin , Xie Jiarong , Xu Lei 
Published: October 2023

Abstract
Background
The risk of extracolonic cancer is increased in inflammatory bowel disease (IBD) patients, but it is not clear whether there is a causal relationship. We aimed to systematically estimate the causal relationship between IBD and extracolonic cancers.

Methods
Independent genetic variants strongly associated with IBD were extracted as instrumental variables from genome-wide association study (GWAS) conducted by the International IBD Genetics Consortium including 12,882 IBD patients, 5956 Crohn’s disease (CD) patients, and 6968 ulcerative colitis (UC) patients. Three sources of cancer GWAS were selected as outcome data. Two-sample Mendelian randomization (MR) analysis was conducted to assess the causal effects of IBD on 32 extracolonic cancers. The meta-analysis was applied to assess the combined causal effect with multiple MR results.

Results
IBD, CD, and UC have potential causal associations with oral cavity cancer (IBD: OR = 1.180, 95% CI: 1.059 to 1.316, P = 0.003; CD: OR = 1.112, 95% CI: 1.008 to 1.227, P = 0.034; UC: OR = 1.158, 95% CI: 1.041 to 1.288, P = 0.007). Meta-analysis showed a significant positive causal relationship between IBD and breast cancer (OR = 1.059; 95% CI: 1.033 to 1.086; P < 0.0001) as well as a potential causal relationship between CD and breast cancer (OR = 1.029; 95% CI: 1.002 to 1.055; P = 0.032) based on combining multiple MR results.

Conclusions
This comprehensive MR analysis suggested that genetically predicted IBD, as well as its subtypes, may be a risk factor in the development of oral cavity and breast cancer.
The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis
Authors: Wang Yue-peng , Di Wen-jia , Yang Su , Qin Shi-lei , Xu Yun-feng , Han Peng-fei , Hou Ke-dong 
Published: October 2023

Abstract
Background
Osteoarthritis (OA) is caused by a complex set of pathophysiological factors. The genetic factors involved in the occurrence and progress of the disease have been widely discussed by scholars. It was found that growth differentiation factor 5 (GDF5) gene polymorphisms may be linked to OA susceptibility, which has been controversial and needs to be further confirmed by an updated meta-analysis.

Objectives
We examined the association between GDF5 rs143383 single nucleotide polymorphism (SNP) and OA susceptibility.

Methods
All relevant articles that met the criteria are retrieved and included, and the search deadline is June 2022. The allele frequencies and different genotype frequencies of GDF5 rs143383 loci in each study were extracted and statistically analyzed by R4.1.3 software, and the different genetic models were analyzed based on their odds ratio (OR) and 95% confidence interval (CI).

Results
The meta-analysis explained that GDF5 rs143383 SNP was crucial correlated with OA in all patients with OA of knee, hip and hand. The codominant gene model in the whole crowd (OR = 1.17, 95% CI 1.07–1.27, P < 0.01) enlightened that OA was vitally associated with GDF5 gene polymorphism. At the same time, we did a subgroup analysis based on ethnicity. The codominant gene model (OR = 1.31, 95% CI 1.12–1.53, P < 0.01) in Asian population, the codominant homozygote model (OR = 1.28, 95% CI 1.14–1.43), codominant heterozygote gene model (OR = 1.12, 95% CI 1.01–1.23, P = 0.02), and dominant gene model (OR = 1.19, 95% CI 1.09–1.31, P < 0.01) in Caucasian are analyzed by subgroup analysis. It means that there is a momentous relationship between the GDF5rs143383 gene polymorphism and OA, especially among Caucasians. In addition, we also discussed different types of OA separately and discover that the GDF5rs143383 gene polymorphism was relevant for knee osteoarthritis (KOA) and hand osteoarthritis, and it was more significant in the Caucasian population. But due to the high heterogeneity in hip osteoarthritis, it could not be accurately concluded. Furthermore, we also analyzed the osteoarthritis of different genders and found that the GDF5 rs143383 SNP was associated with both men and women and was still significant in the Caucasian population.

Conclusion
We found a close association between osteoarthritis and GDF5rs143383SNP in this study. From the analysis of each group, we got the same conclusion in KOA and hand OA, but which need further verification in hip OA. Considering gender, we found a close relationship between GDF5 rs143383 SNP and OA of the knee, hip and hand, both for men and women. This conclusion is more obvious in Caucasian people.
Excision of left atrial myxoma under perfused ventricular fibrillation with hypothermia after coronary artery bypass grafting
Authors: Pan Shaobo , Wang Yalin , Gu Yanjia , Li Weidong , Xu Hongfei 
Published: October 2023

Abstract
Background
Redo heart surgery has become increasingly common but involves additional high surgical risk, especially redo surgery after coronary artery bypass grafting (CABG).

Case presentation
In this study, we report the case of a 57-year-old Chinese male with left atrium myxoma who had previously undergone CABG. Common surgical methods usually include aortic cross-clamping, administering cold cardioplegia perfusion to protect the myocardium, opening the heart, and then removing the tumor. However, for patients with previous CABG, redo thoracotomy and ascending aortic cross-clamping present a greater risk of damage to the grafted vessels. In this study, we chose a right lateral mini-thoracotomy incision and hypothermia-induced ventricular fibrillation to minimize damage and avoid any adverse effects on the bridge vasculature. The patient recovered uneventfully and was discharged seven days after surgery.

Conclusions
For patients with previous CABG, minimally invasive right thoracotomy under perfused ventricular fibrillation with hypothermia is safe and reliable and can prevent potential damage to the ascending aorta and graft.