bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propuesta de actividad para el fortalecimiento del aprendizaje colaborativo en los estudiantes de octavo año de educación básica
Authors: Sarmiento Crespo Andrea Cecibel , González Maldonado Diana Cecilia 
Published: November 2023

Introducción: El aprendizaje colaborativo es una metodología de aprendizaje que permite fortalecer el desarrollo integral de los estudiantes. Objetivos: el presente trabajo investigación tiene como objetivo plantear una propuesta de actividades para fortalecer el aprendizaje colaborativa en los estudiantes del octavo año de educación básica de la Unidad Educativa José Benigno Iglesias de la ciudad de Biblián para así lograr potenciar el proceso de enseñanza-aprendizaje de los estudiantes. Metodología: La metodología que se utilizó en este estudio es: el método histórico-lógico para recurrir a consultas bibliográficas con el propósito de estudiar los conceptos, nexos y leyes generales del proceso de enseñanza en el aprendizaje colaborativo para precisar conceptos teóricos del objeto de investigación. Un enfoque mixto utilizando la técnica de la encuesta a través de un cuestionario como instrumento basado en 10 preguntas previamente seleccionadas y aplicadas a 35 estudiantes de este establecimiento, para conocer los problemas que afrontan los estudiantes para aplicar adecuadamente esta metodología Resultados: una vez realizada la encuesta se procedió a tabular los resultados donde se evidencia que los estudiantes conocían esta metodología de aprendizaje, pero no la desarrollaban adecuadamente, pero con nuevas actividades logran un aprendizaje significativo. Conclusiones: en conclusión, se logró fortalecer el aprendizaje colaborativo mediante la utilización de proyectos en los estudiantes. Área de estudio general: Educación. Área de estudio específica: Educación Básica.
Efficacy of Chinese traditional patent medicines for heart failure with preserved ejection fraction: a Bayesian network meta-analysis of 64 randomized controlled trials
Authors: Guo Hongxin , Zhu Mingjun , Yu Rui , Li Xingyuan , Zhao Qifei 
Published: November 2023

BackgroundHeart failure with preserved ejection fraction (HFpEF) is associated with substantial morbidity and mortality, and modern medicine offers less effective treatment for HFpEF. Much evidence shows that Chinese traditional patent medicines (CTPMs) have good efficacy for HFpEF, but the advantages and disadvantages of different CTPMs for HFpEF are still unclear. This study used network meta-analysis (NMA) to compare clinical efficacies of different CTPMs for HFpEF.MethodsRandomized controlled trials (RCTs) of CTPMs for treating HFpEF were searched in seven Chinese and English databases from inception to September 2023: China National Knowledge Infrastructure (CNKI), Wanfang, VIP, China Biology Medicine, PubMed, Cochrane Library, and Embase. Two researchers independently screened the literature, extracted data, and evaluated the quality of the included studies. The GeMTC package in R (version 4.1.2) was used to perform Bayesian NMA.ResultsA total of 64 RCTs were included, involving six CTPMs and 6,238 patients. The six CTPMs were Qili Qiangxin capsule (QLQXC), Qishen Yiqi dropping pill (QSYQDP), Yixinshu capsule (YXSC), Yangxinshi tablet (YXST), Shexiang Baoxin Pill (SXBXP), and Tongxinluo capsule (TXLC). Conventional Western medicine (CWM) treatment was given to the control group, and CWM treatment combined with CTPM treatment was given to the experimental group. The results indicated that CPTMs + CWM were all superior to CWM alone; SXBXP + CWM had the best efficacies in improving the New York Heart Association cardiac functional classification efficiency; TXLC + CWM was best at improving the ratio of early diastolic mitral inflow velocity to late diastolic mitral inflow velocity (E/A); QSYQDP + CWM was best at reducing N-terminal pro-B type natriuretic peptide (NT-proBNP); and QSYQDP + CWM was best at improving the 6-min walking test. In terms of safety, there was no signiﬁcant difference between CTPMs + CWM and CWM.ConclusionCompared with CWM alone, CTPMs + CWM combinations have certain advantages and good safety in the treatment of HFpEF. QSYQDP + CWM and SXBXP + CWM may be the potential optimal integrative medicine-based treatments for HFpEF. Given the limitations of this study, further high-quality, multicenter, large sample, randomized, and double-blind studies are needed to confirm the current results.Systematic Review Registrationidentifier, CRD42022303938.
Noncardiac anomalies in children with congenital heart disease
Authors: Huang Xianghui , Gao Yuan , Chen Weicheng , Sheng Wei , Huang Guoying 
Published: November 2023

IntroductionNoncardiac anomalies (NCAs) in patients with congenital heart defects (CHDs) are crucial for perioperative management and etiology studies. This study aimed to investigate NCAs in Chinese children with CHDs.MethodsMedical records for CHD-diagnosed children hospitalized from 1 January 2015 to 31 December 2019 were collected and subjected to retrospective analyses to excavate potential association rules between CHDs and noncardiac malformations.ResultsA total of 3,788 CHD patients were included in this study. The main phenotypes of CHD were Ventricular Septal Defect (VSD, 33.69%), Atrial Septal Defect (ASD, 12.72%), and Tetralogy of Fallot (TOF, 5.54%). A total of 887 (23.42%) cases showed noncardiac anomalies, which were mainly associated with the central nervous system (34.61%), nose/ear/mandibular/face (19.39%), genitourinary system (15.78%), and musculoskeletal system (15.56%). Compared to other CHD subtypes, septal defects had a lower percentage of associated NCAs (P = 3.7 × 10−9) while AVSD had a higher percentage (P = 0.0018).DisscussionNCAs are prevalent among CHD-diagnosed children in China, and the spectrums of NCAs in different CHD subcategories were different.
Sustainable manufacture and application of biochar to improve soil properties and remediate soil contaminated with organic impurities: a systematic review
Authors: Rizwan Muhammad , Murtaza Ghulam , Zulfiqar Faisal , Moosa Anam , Iqbal Rashid , Ahmed Zeeshan , Irshad Sana , Khan Imran , Li Tonghao , Chen Jiefeng , Zhang Mingguang , Siddique Kadambot H. M. , Leng Lijian , Li Hailong 
Published: November 2023

Biochar production and application have become increasingly popular in the past 15 years. Biochar, derived from diverse biomass types, offers a rich carbon source created through thermal combustion. Biochar production primarily depends on pyrolysis conditions and feedstock type. This review focuses on the multifaceted aspects of biochar, encompassing hydrothermal carbonization, gasification, and pyrolysis temperatures in biochar production and its role in bioeconomy and soil remediation. Biochar has yielded valuable insights, notably in decreasing nutrient leaching, curbing greenhouse gas (GHG) emissions, reducing the bioavailability of environmental pollutants, sequestering carbon (C) in soils, and enhancing agricultural productivity. Consequently, it has emerged as a valuable commodity for the bioeconomy, which involves harnessing bioresources through bioengineering to create economically valuable products. As a marketable output, biochar finds application in energy, diverse biochar-based product manufacturing, and the agricultural sector. Thus, biochar production not only enhances soil quality but also unlocks additional revenue streams. This review underscores the critical role of feedstock selection and pyrolysis conditions in optimizing biochar production. Furthermore, it highlights biochar as a sustainable and effective tool for improving various soil types and remediating soil contamination caused by organic impurities, including persistent organic compounds and antibiotics.
Chronic systemic capillary leak syndrome with lymphatic capillaries involvement and MYOF mutation: case report and literature review
Authors: Gao Dehua , Zhong Wen , Zhang Weiru , Wang Xuan , Li Weiping , Liu Jun 
Published: November 2023

Introduction: Idiopathic systemic capillary leak syndrome (SCLS) is a rare disorder characterized by hemoconcentration, hypoproteinemia and edema. Chronic SCLS (cSCLS) presents as intractable edema, distinguishing it from the classic acute form, and only about 10 cases were reported worldwide. Nevertheless, the underlying pathogenesis of both types is obscure.Case presentation: We report a case of a 58-year-old man with chronic edema persisting for 8 years, complicated by unique chylous polyserous effusions and hypotrichosis, which was successfully relieved by treatment with dexamethasone, intravenous immunoglobulin, and thalidomide. Furthermore, a variant c.5594A&gt;G (p.K1865R) in the MYOF gene was identified as a potentially pathogenic mutation through whole-exome genetic sequencing. The proposed mechanism involves its impact on VEGF signaling, leading to increased capillary permeability.Conclusion: Our case illustrates possible lymphatic capillaries involvement in SCLS, which may plays a potential role in immune disorder, and revealed a possible causative genetic mutation of SCLS.
Preoperative systemic immune-inflammation index as a prognostic indicator for patients with urothelial carcinoma
Authors: Zheng Jianxiong , Peng Lei , Zhang Shaohua , Liao Haiyang , Hao Jiayao , Wu Song , Shen Haili 
Published: November 2023

BackgroundThe systemic immune-inflammation index (SII) is a cost-efficient indicator for carcinoma prognosis. However, its utility in urothelial carcinoma (UC) prognosis is disputed. This meta-analysis aims to assess SII’s prognostic value in UC.MethodsA thorough search of databases including PubMed, Web of Science, Embase, Cochrane Library, and Scopus, was conducted to find studies until January 11, 2023. Eligibility criteria were applied to select studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted from selected studies and compiled in a meta-analysis to gauge SII’s association with survival outcomes such as overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS), and progression-free survival (PFS).ResultsThis analysis includes 19 studies with 12505 UC patients. It was found that high SII significantly correlated with worse OS in UC patients (HR 1.430, 95% CI 1.237-1.653, P&lt;0.001). High SII values also linked with poorer CSS (HR 1.913, 95% CI 1.473-2.485, P&lt;0.001), RFS (HR 1.240, 95% CI 1.097-1.403, P=0.001), and PFS (HR 1.844, 95% CI 1.488-2.284, P&lt;0.001) compared to low SII values. Subgroup analysis revealed SII’s consistent prognostic value in UC across races, carcinoma types, sample sizes, and SII cut-off values, suggesting its potential as a prognostic indicator in UC patients.ConclusionCurrent evidence suggests SII as a promising, cost-efficient predictor in UC patients. This meta-analysis indicates SII’s potential as a valuable prognostic tool in UC patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=307643, identifier CRD42022307643.
Nutritional ecology of temperate octocorals in a warming ocean
Authors: Lange Kiara , Maguer Jean-François , Reynaud Stéphanie , Ferrier-Pagès Christine 
Published: November 2023

Global warming of the oceans poses a double threat to benthic organisms as they reach their thermal limits and starve to death due to declines in plankton abundance during heat waves. Under these circumstances, dissolved nutrients become an important alternative food source, especially in temperate regions where they can reach high concentrations. Although octocorals play a central role in temperate Marine Animal Forests and benthic-pelagic coupling, our knowledge of their feeding ecology is still limited. We used 13C and 15N isotope labeling to investigate feeding rates on dissolved inorganic (carbon, ammonium, nitrate) and organic (urea, amino acids) nutrients of the two most common Mediterranean gorgonians, the mixotrophic species Eunicella singularis and the heterotrophic species Paramuricea clavata. We also measured the uptake of natural dissolved organic matter (DOM) provided at different concentrations. Measurements were conducted at 17°C and 24°C to anticipate the effects of ocean warming. Our findings indicate that gorgonians exhibit notably low uptake rates of dissolved inorganic and organic nutrients, both at 17°C and 24°C. At 24°C, gorgonians experienced heat stress, as evidenced by elevated respiration rates, the loss of symbionts in E. singularis, and decreased lipid reserves in P. clavata. However, we did not observe a significant increase in the uptake rates of dissolved inorganic or organic nutrients, except for dissolved organic carbon in E. singularis. This study provides valuable insight into the nutritional requirements of temperate octocorals. The results demonstrate that dissolved nutrients, in particular nitrogen, do not play a substantial role in the diet of gorgonians, suggesting that these organisms primarily rely on the capture of plankton and detrital material for their nitrogen requirements. Therefore, temperate octocorals may be at high risk of severe starvation in the future.
Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus
Authors: Almassri Laila S. , Ohl Andrew P. , Iafrate Milena C. , Wade Aidan D. , Tokar Nick J. , Mafi Amir M. , Beebe Nichole L. , Young Jesse W. , Mellott Jeffrey G. 
Published: November 2023

IntroductionDisruptions to the balance of excitation and inhibition in the inferior colliculus (IC) occur during aging and underlie various aspects of hearing loss. Specifically, the age-related alteration to GABAergic neurotransmission in the IC likely contributes to the poorer temporal precision characteristic of presbycusis. Perineuronal nets (PNs), a specialized form of the extracellular matrix, maintain excitatory/inhibitory synaptic environments and reduce structural plasticity. We sought to determine whether PNs increasingly surround cell populations in the aged IC that comprise excitatory descending projections to the cochlear nucleus.MethodWe combined Wisteria floribunda agglutinin (WFA) staining for PNs with retrograde tract-tracing in three age groups of Fischer Brown Norway (FBN) rats.ResultsThe data demonstrate that the percentage of IC-CN cells with a PN doubles from ~10% at young age to ~20% at old age. This was true in both lemniscal and non-lemniscal IC.DiscussionFurthermore, the increase of PNs occurred on IC cells that make both ipsilateral and contralateral descending projections to the CN. These results indicate that reduced structural plasticity in the elderly IC-CN pathway, affecting excitatory/inhibitory balance and, potentially, may lead to reduced temporal precision associated with presbycusis.
Clinical applications of neurofeedback based on sensorimotor rhythm: a systematic review and meta-analysis
Authors: Ribeiro Tatiana Ferri , Carriello Marcelo Alves , de Paula Eugenio Pereira , Garcia Amanda Carvalho , Rocha Guilherme Luiz da , Teive Helio Afonso Ghizoni 
Published: November 2023

BackgroundAmong the brain-machine interfaces, neurofeedback is a non-invasive technique that uses sensorimotor rhythm (SMR) as a clinical intervention protocol. This study aimed to investigate the clinical applications of SMR neurofeedback to understand its clinical effectiveness in different pathologies or symptoms.MethodsA systematic review study with meta-analysis of the clinical applications of EEG-based SMR neurofeedback performed using pre-selected publication databases. A qualitative analysis of these studies was performed using the Consensus tool on the Reporting and Experimental Design of Neurofeedback studies (CRED-nf). The Meta-analysis of clinical efficacy was carried out using Review Manager software, version 5.4.1 (RevMan 5; Cochrane Collaboration, Oxford, UK).ResultsThe qualitative analysis includes 44 studies, of which only 27 studies had some kind of control condition, five studies were double-blinded, and only three reported a blind follow-up throughout the intervention. The meta-analysis included a total sample of 203 individuals between stroke and fibromyalgia. Studies on multiple sclerosis, insomnia, quadriplegia, paraplegia, and mild cognitive impairment were excluded due to the absence of a control group or results based only on post-intervention scales. Statistical analysis indicated that stroke patients did not benefit from neurofeedback interventions when compared to other therapies (Std. mean. dif. 0.31, 95% CI 0.03–0.60, p = 0.03), and there was no significant heterogeneity among stroke studies, classified as moderate I2 = 46% p-value = 0.06. Patients diagnosed with fibromyalgia showed, by means of quantitative analysis, a better benefit for the group that used neurofeedback (Std. mean. dif. −0.73, 95% CI −1.22 to −0.24, p = 0.001). Thus, on performing the pooled analysis between conditions, no significant differences were observed between the neurofeedback intervention and standard therapy (0.05, CI 95%, −0.20 to −0.30, p = 0.69), with the presence of substantial heterogeneity I2 = 92.2%, p-value &lt; 0.001.ConclusionWe conclude that although neurofeedback based on electrophysiological patterns of SMR contemplates the interest of numerous researchers and the existence of research that presents promising results, it is currently not possible to point out the clinical benefits of the technique as a form of clinical intervention. Therefore, it is necessary to develop more robust studies with a greater sample of a more rigorous methodology to understand the benefits that the technique can provide to the population.
Accuracy of reticulocyte hemoglobin for diagnosing iron deficiency in former very preterm infants: a population-based cohort study
Authors: Barr Hudson , Kulkarni Ketan , Singh Balpreet , Sandila Navjot , Morrison Lisa , Beach Lori , Ghotra Satvinder 
Published: November 2023

BackgroundSerum ferritin (SF) is commonly used to diagnose iron deficiency (ID) but has limitations. Reticulocyte hemoglobin (Ret-He) is being increasingly used for ID diagnosis. This study aimed to assess accuracy of Ret-He for ID diagnosis in former very preterm infants (VPI) at 4–6 months corrected age (CA).MethodsA retrospective population-based cohort study was conducted on all live VPI born between 23 and 30 weeks of gestational age (GA) in Nova Scotia from 2012 to 2018. Infants underwent SF and Ret-He testing at 4–6 months CA. ID was defined using two definitions. The first defined ID as SF &lt; 20 mcg/L at both 4- and 6-months CA, and the second as SF &lt; 30 mcg at at both 4- and 6-months CA. The accuracy of Ret-He for identifying ID was assessed using the area under the receiver operating characteristic curve (AUC).ResultsID was present in 39.7% (62) of 156 infants in the first definition and 59.6% (93) in the second at 4–6 months CA. The AUC of Ret-He for ID diagnosis was 0.64 (p = 0.002) in the first definition and 0.59 (p = 0.04) in the second. The optimal cut-off was 29.4pg in the first and 29.7 in the second definition. The sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPV) at the 29.4 pg cut-off were 50.0%, 78.7%, 60.8%, and 70.5% for definition 1 and 44.1%, 74.6%, 71.9%, and 47.5% at the 29.7pg cut-off for definition 2.ConclusionRet-He had low diagnostic accuracy for ID diagnosis in former VPI. Caution is advised when using Ret-He alone for ID diagnosis. Further research is needed to establish optimal approaches for identifying ID in VPI.
Identification of the ALMT gene family in the potato (Solanum tuberosum L.) and analysis of the function of StALMT6/10 in response to aluminum toxicity
Authors: Zhang Feng , Jiang Sixia , Li Qiong , Song Zhiying , Yang Ying , Yu Shirui , Nie Zongyue , Chu Moli , An Yanlin 
Published: November 2023

IntroductionAluminum (Al)-activated malate transporters (ALMTs) play an important role in the response to Al toxicity, maintenance of ion homeostasis balance, mineral nutrient distribution, and fruit quality development in plants. However, the function of the StALMT gene family in potato remains unknown.Methods and resultsIn this study, 14 StALMT genes were identified from the potato genome, unevenly distributed on seven different chromosomes. Collinearity and synteny analyses of ALMT genes showed that potatoes had 6 and 22 orthologous gene pairs with Arabidopsis and tomatoes, respectively, and more than one syntenic gene pair was identified for some StALMT gene family members. Real-time quantitative polymerase chain reaction (qPCR) results showed differential expression levels of StALMT gene family members in different tissues of the potato. Interestingly, StALMT1, StALMT6, StALMT8, StALMT10, and StALMT12 had higher expression in the root of the potato cultivar Qingshu No. 9. After being subjected to Al3+ stress for 24 h, the expression of StALMT6 and StALMT10 in roots was evidently increased, displaying their decisive role in Al3+ toxicity.DiscussionIn addition, overexpression of StALMT6 and StALMT10 in Arabidopsis enhanced its tolerance to Al toxicity. These results indicate that StALMT6 and StALMT10 impart Al3+ resistance in the potato, establishing the foundation for further studies of the biological functions of these genes.
Nano-microplastic and agro-ecosystems: a mini-review
Authors: Verma Krishan K. , Song Xiu-Peng , Xu Lin , Huang Hai-Rong , Liang Qiang , Seth Chandra Shekhar , Li Yang-Rui 
Published: November 2023

Plastics’ unavoidable and rampant usage causes their trash to be extensively dispersed in the atmosphere and land due to its numerous characteristics. Because of extensive plastic usage and increased manufacturing, there is insufficient recycling and a large accumulation of microplastics (MPs) in the environment. In addition to their wide availability in the soil and atmosphere, micro- and nanoplastics are becoming contaminants worldwide. Agro-ecosystem functioning and plant development are being negatively impacted in several ways by the contamination of the environment and farmland soils with MPs (&lt;5 mm) and nanoplastics (&lt;1 µm). The contributions of some recyclable organic waste and plastic film mulching and plastic particle deposition in agroecosystems may be substantial; therefore, it is crucial to understand any potentially hazardous or undesirable impacts of these pollutants on agroecosystems. The dissolution of bioplastics into micro- and nano-particles (MBPs and NBPs) has not been considered in recent studies, which focus primarily on agro-ecosystems. It is essential to properly understand the distribution, concentration, fate, and main source of MPs, NPS, MBPs, and NBPs in agroecosystems. Based on the limited findings, understanding the knowledge gap of environmental impact from micro and nanoplastic in farming systems does not equate to the absence of such evidence. It reveals the considerations for addressing the gaps to effectively protect global food safety and security in the near future.