bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die zirkadiane Uhr und das Verhalten
Authors: Ripperger Jürgen A. , Albrecht Urs 
Published: February 2024

AbstractMost organisms have evolved an internal clock to predict daily recurring events. This clock with a period of about 24 hours, termed circadian clock, allows organisms to organize biochemical and physiological processes over one day. Changes in lighting conditions as they occur naturally over seasons or man-made by jet lag or shift work, change sleep phase in order to synchronize an organism’s physiology to the environment. A misalignment results in sleep disturbance and mood disorders. Here we discuss how we study various body clocks in mice to understand their synchronization avoiding development of disease.
Strukturbiologie der systemischen Amyloidosen
Authors: Haupt Christian , Schmidt Matthias , Fändrich Marcus 
Published: February 2024

AbstractSystemic amyloidosis refers to a group of diseases that are caused by the misfolding of proteins and their deposition as amyloid fibrils in various organs. Here we present an overview of the progress made in the understanding of the biochemical and structural characteristics of the pathogenic agents of these diseases, obtained by using cryo-electron microscopy. The observed structures provided insights in the molecular etiology of the diseases and helped to shed light on the mechanism of misfolding in the affected patients.
Genetic Engineering von Mikroalgen für eine nachhaltige Zukunft
Authors: Hallmann Armin 
Published: February 2024

AbstractThe significance of microalgae biotechnology is rising in many fields, including the food, pharmaceutical, nutraceutical, cosmetic, feed, and energy industries. Microalgae can also be genetically modified to give them additional traits and produce substances that are not typically seen in algae. Rapid advances in “omics” technologies and the availability of a variety of molecular tools have been the driving forces behind advancements in genetic engineering of microalgae for a sustainable future.
Virusähnliche Partikel – Impfstoffe, die den Eindringling imitieren
Authors: Klausberger Miriam , Satzer Peter , Aguilar Patricia Pereira 
Published: February 2024

AbstractVirus-like particle vaccines have emerged as a promising and innovative approach to combat infectious diseases. Despite their immense potential as platform technology, challenges related to their production process need to be addressed to harness their full capabilities and make them widely assessible for human application.
Algorithms Don’t Have A Future: On the Relation of Judgement and Calculation
Authors: Stader Daniel 
Published: February 2024

AbstractThis paper is about the opposite of judgement and calculation. This opposition has been a traditional anchor of critiques concerned with the rise of AI decision making over human judgement. Contrary to these approaches, it is argued that human judgement is not and cannot be replaced by calculation, but that it is human judgement that contextualises computational structures and gives them meaning and purpose. The article focuses on the epistemic structure of algorithms and artificial neural networks to find that they always depend on human judgement to be related to real life objects or purposes. By introducing the philosophical concept of judgement, it becomes clear that the property of judgement to provide meaning and purposiveness is based on the temporality of human life and the ambiguity of language, which quantitative processes lack. A juxtaposition shows that calculations and clustering can be used and referred to in more or less prejudiced and reflecting as well as opaque and transparent ways, but thereby always depend on human judgement. The paper clearly asserts that the transparency of AI is necessary for their autonomous use. This transparency requires the explicitness of the judgements that constitute these computational structures, thereby creating an awareness of the conditionality of such epistemic entities.
Emulation-based adaptive differential evolution: fast and auto-tunable approach for moderately expensive optimization problems
Authors: Nishihara Kei , Nakata Masaya 
Published: February 2024

AbstractIn the field of expensive optimization, numerous papers have proposed surrogate-assisted evolutionary algorithms (SAEAs) for a few thousand or even hundreds of function evaluations. However, in reality, low-cost simulations suffice for a lot of real-world problems, in which the number of function evaluations is moderately restricted, e.g., to several thousands. In such moderately restricted scenario, SAEAs become unnecessarily time-consuming and tend to struggle with premature convergence. In addition, tuning the SAEA parameters becomes impractical under the restricted budgets of function evaluations—in some cases, inadequate configuration may degrade performance instead. In this context, this paper presents a fast and auto-tunable evolutionary algorithm for solving moderately restricted expensive optimization problems. The presented algorithm is a variant of adaptive differential evolution (DE) algorithms, and is called emulation-based adaptive DE or EBADE. The primary aim of EBADE is to emulate the principle of sample-efficient optimization, such as that in SAEAs, by adaptively tuning the DE parameter configurations. Specifically, similar to Expected Improvement-based sampling, EBADE identifies parameter configurations that may produce expected-to-improve solutions, without using function evaluations. Further, EBADE incepts a multi-population mechanism and assigns a parameter configuration to each subpopulation to estimate the effectiveness of parameter configurations with multiple samples carefully. This subpopulation-based adaptation can help improve the selection accuracy of promising parameter configurations, even when using an expected-to-improve indicator with high uncertainty, by validating with respect to multiple samples. The experimental results demonstrate that EBADE outperforms modern adaptive DEs and is highly competitive compared to SAEAs with a much shorter runtime.
The Market in the Kingdom of Ends
Authors: Santori Paolo 
Published: February 2024

AbstractIn the literature on the Moral Limits of the Markets, Kant’s moral philosophy is often employed to assess the amoral or immoral nature of the commercial sphere. Markets and morality are antipodes since the instrumentality of market transactions excludes or undermines moral values. The kingdom of ends, where everything has either a price or a dignity, closes the door to market logic. The present paper challenges this view, which is also endorsed by business ethics authors advocating for Moral Purism. I will show that Kant imagined a market within the Kingdom of Ends where everyone pursues their own aims while assisting others in pursuing theirs. This model, built on the universalization of the maxim of mutual assistance and the duty of honoring the spirit of mutually beneficial contracts, can be employed to judge the morality of real (empirical) market transactions.
Stakeholder Cues, National Origin, and Public Opinion Towards Firms: Evidence in the Context of the First Bank in an American Indian Nation
Authors: Wellhausen Rachel L. , Feir Donn L. , Thrall Calvin 
Published: February 2024

AbstractWhen and how does stakeholder credibility matter in shaping public opinion? We explore this question in a real-world setting: in order to fight its citizens’ financial exclusion—a key barrier to development in Indian Country—American Indian Nation “A” negotiated the first entry of the first bank to its reservation. The bank is owned by American Indian Nation “B.” To the Federal Reserve, the bank branch is a potential proof-of-concept for the capacity of tribe-to-tribe investment to improve capital access in underserved Native communities. The bank’s success ultimately depends on whether Nation A’s citizens use its services; in the months before its opening, all three stakeholders independently attempted to influence public opinion toward the bank. We collaborated to conduct a first-of-its-kind survey of Nation A’s tribal members, finding high baseline buy-in especially given the bank’s nationality, but weak and even counterproductive treatment effects of pro-banking cues provided by Nation A and the Federal Reserve. Our results make clear the practical benefits of theory-building around stakeholder credibility, and the crucial role of individual attitudes in the political economy of development.
Business politics is usually about attempts to exert influence rather than power. Evidence from Australia
Authors: Bell Stephen , Hindmoor Andrew 
Published: February 2024

AbstractWe argue that the everyday language distinction drawn between power and influence is meaningful and significant. There is good reason to believe that much corporate lobbying activity which is currently described under the heading of business power is better understood as attempts to secure negotiated agreements based on exerting influence rather than power and that the latter is usually used only when attempts to use influence have failed. We develop an analytical distinction between influence, understood as successful efforts at persuasion, and power using Keith Dowding’s work on power. Drawing upon findings from interviews with corporate professionals operating at the coalface of business and government interaction in Australia, we show that lobbyists generally seek “quiet” behind-the-scenes accommodations with governments via attempts to exert influence rather than power.
The effects of word and beat priming on Mandarin lexical stress recognition: an event-related potential study
Authors: Yu Wenjing , Chien Yu-Fu , Wang Bing , Zhao Jianjun , Li Weijun 
Published: February 2024

AbstractMusic and language are unique communication tools in human society, where stress plays a crucial role. Many studies have examined the recognition of lexical stress in Indo-European languages using beat/rhythm priming, but few studies have examined the cross-domain relationship between musical and linguistic stress in tonal languages. The current study investigates how musical stress and lexical stress influence lexical stress recognition in Mandarin. In the auditory priming experiment, disyllabic Mandarin words with initial or final stress were primed by disyllabic words or beats with either congruent or incongruent stress patterns. Results showed that the incongruent condition elicited larger P2 and the late positive component (LPC) amplitudes than the congruent condition. Moreover, the Strong-Weak primes elicited larger N400 amplitudes than the Weak-Strong primes, and the Weak-Strong primes yielded larger LPC amplitudes than the Strong-Weak primes. The findings reveal the neural correlates of the cross-domain influence between music and language during lexical stress recognition in Mandarin.
ARCHITECTURAL MEMORY AND TRIMALCHIO'S PORTICVS
Authors: Anguissola Anna 
Published: February 2024

AbstractThis paper seeks to respond to two questions posed by previous commentators concerning the arrangement of Trimalchio's porticus as described in Petronius’ Satyrica (Sat. 29): first, whether the freedman's house lacked an atrium; second, whether the cursores (runners) who are described as unconventionally exercising in the portico were pictorial representations or real-life athletes who would symbolize the social incompetence of the dominus. This paper argues that nothing in the text supports the interpretation of Trimalchio's house as having an unconventional architectural layout. Instead, as the narrative requires that Encolpius move quickly towards the triclinium, in his description the loca communia appear conflated, while he only sparsely notices a few relevant elements of the decor. The presentation of Trimalchio's porticus appears to have a functional rather than a simply descriptive purpose: it symbolizes both Roman contemporary practices (the loca communia as a distinctive unit within the domus) and the influence of Greek cultural habits (the characteristic association of colonnaded courtyards and athletics). The excerpt that describes the guests’ arrival at Trimalchio's house, therefore, serves an important narrative function, providing essential information about the character's origins, self-image and social life.
Enlarged pituitary gland volume: a possible state rather than trait marker of psychotic disorders
Authors: Guimond Synthia , Alftieh Ahmad , Devenyi Gabriel A. , Mike Luke , Chakravarty M. Mallar , Shah Jai L. , Parker David A. , Sweeney John A. , Pearlson Godfrey , Clementz Brett A. , Tamminga Carol A. , Keshavan Matcheri 
Published: February 2024

AbstractBackgroundEnlarged pituitary gland volume could be a marker of psychotic disorders. However, previous studies report conflicting results. To better understand the role of the pituitary gland in psychosis, we examined a large transdiagnostic sample of individuals with psychotic disorders.MethodsThe study included 751 participants (174 with schizophrenia, 114 with schizoaffective disorder, 167 with psychotic bipolar disorder, and 296 healthy controls) across six sites in the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium. Structural magnetic resonance images were obtained, and pituitary gland volumes were measured using the MAGeT brain algorithm. Linear mixed models examined between-group differences with controls and among patient subgroups based on diagnosis, as well as how pituitary volumes were associated with symptom severity, cognitive function, antipsychotic dose, and illness duration.ResultsMean pituitary gland volume did not significantly differ between patients and controls. No significant effect of diagnosis was observed. Larger pituitary gland volume was associated with greater symptom severity (F = 13.61, p = 0.0002), lower cognitive function (F = 4.76, p = 0.03), and higher antipsychotic dose (F = 5.20, p = 0.02). Illness duration was not significantly associated with pituitary gland volume. When all variables were considered, only symptom severity significantly predicted pituitary gland volume (F = 7.54, p = 0.006).ConclusionsAlthough pituitary volumes were not increased in psychotic disorders, larger size may be a marker associated with more severe symptoms in the progression of psychosis. This finding helps clarify previous inconsistent reports and highlights the need for further research into pituitary gland-related factors in individuals with psychosis.
Kṛṣṇa the Magician: metapoesis and ambivalence in Faiḍī's Mahābhārat
Authors: Smolin Justin N. 
Published: February 2024

AbstractIn this article, I discuss the vilification of Kṛṣṇa as a deceitful sorcerer in the Mughal poet-laureate Shaikh Abū'l Faiḍ bin Mubārak, or ‘Faiḍī's Mahābhārat and his correspondent apotheosis as the ‘essence of the True God' in the Shāriq al-maʿrifat, a treatise also ascribed to Faiḍī. As I argue, this inconsistency, or ambivalence, is a common and overlooked facet of the elite Islamicate engagement with religious diversity and difference in early modern Hindustan. In the case of the Mahābhārat, however, Faiḍī's portrayal of Kṛṣṇa as a deceitful illusionist reflects not only an Islamic discomfort with Vaishnavite theology, but Faiḍī's own performative insecurities as a Hindustani writer of Persian poetry and literary prose. Kṛṣṇa's so-called ‘magic’ lies in large part in his way with words: the verbal and social manipulation he uses to stoke the flames of conflict. The character thus becomes a kind of shadow or double of Faiḍī himself-a demiurgic author of the Mahābhārat upon which the poet can displace the classical Islamicate association of poetry with sorcery and deceit.
A pilot study of chlormequat in food and urine from adults in the United States from 2017 to 2023
Authors: Temkin Alexis M. , Evans Sydney , Spyropoulos Demetri D. , Naidenko Olga V. 
Published: February 2024

Abstract
Chlormequat chloride is a plant growth regulator whose use on grain crops is on the rise in North America. Toxicological studies suggest that exposure to chlormequat can reduce fertility and harm the developing fetus at doses lower than those used by regulatory agencies to set allowable daily intake levels. Here we report, the presence of chlormequat in urine samples collected from people in the U.S., with detection frequencies of 69%, 74%, and 90% for samples collected in 2017, 2018–2022, and 2023, respectively. Chlormequat was detected at low concentrations in samples from 2017 through 2022, with a significant increase in concentrations for samples from 2023. We also observed high detection frequencies of chlormequat in oat-based foods. These findings and chlormequat toxicity data raise concerns about current exposure levels, and warrant more expansive toxicity testing, food monitoring, and epidemiological studies to assess health effects of chlormequat exposures in humans.

Impact

This study reports the detection of chlormequat, an agricultural chemical with developmental and reproductive toxicity, in the U.S. population and U.S. food supplies for the first time. While similar levels of the chemical were found in urine sampled from 2017 to 2022, markedly increased levels were found in samples from 2023. This work highlights the need for more expansive monitoring of chlormequat in U.S. foods and in human specimens, as well as toxicological and epidemiological study on chlormequat, as this chemical is an emerging contaminant with documented evidence of low-dose adverse health effects in animal studies.
Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia
Authors: Boncompagni Gioia , Tatangelo Vanessa , Lopresti Ludovica , Ulivieri Cristina , Capitani Nagaja , Tangredi Carmela , Finetti Francesca , Marotta Giuseppe , Frezzato Federica , Visentin Andrea , Ciofini Sara , Gozzetti Alessandro , Bocchia Monica , Calzada-Fraile Diego , Martin Cofreces Noa B. , Trentin Livio , Patrussi Laura , Baldari Cosima T. 
Published: February 2024

AbstractThe tumor microenvironment (TME) plays a central role in the pathogenesis of chronic lymphocytic leukemia (CLL), contributing to disease progression and chemoresistance. Leukemic cells shape the TME into a pro-survival and immunosuppressive niche through contact-dependent and contact-independent interactions with the cellular components of the TME. Immune synapse (IS) formation is defective in CLL. Here we asked whether soluble factors released by CLL cells contribute to their protection from cytotoxic T cell (CTL)-mediated killing by interfering with this process. We found that healthy CTLs cultured in media conditioned by leukemic cells from CLL patients or Eμ-TCL1 mice upregulate the exhaustion marker PD-1 and become unable to form functional ISs and kill target cells. These defects were more pronounced when media were conditioned by leukemic cells lacking p66Shc, a proapoptotic adapter whose deficiency has been implicated in disease aggressiveness both in CLL and in the Eμ-TCL1 mouse model. Multiplex ELISA assays showed that leukemic cells from Eμ-TCL1 mice secrete abnormally elevated amounts of CCL22, CCL24, IL-9 and IL-10, which are further upregulated in the absence of p66Shc. Among these, IL-9 and IL-10 were also overexpressed in leukemic cells from CLL patients, where they inversely correlated with residual p66Shc. Using neutralizing antibodies or the recombinant cytokines we show that IL-9, but not IL-10, mediates both the enhancement in PD-1 expression and the suppression of effector functions in healthy CTLs. Our results demonstrate that IL-9 secreted by leukemic cells negatively modulates the anti-tumor immune abilities of CTLs, highlighting a new suppressive mechanism and a novel potential therapeutical target in CLL.
A novel bystander effect in tamoxifen treatment: PPIB derived from ER+ cells attenuates ER− cells via endoplasmic reticulum stress-induced apoptosis
Authors: Yang Tinglin , Li Wenhui , Zhou Jun , Xu Ming , Huang Ziwei , Ming Jie , Huang Tao 
Published: February 2024

AbstractTamoxifen (TAM) is the frontline therapy for estrogen receptor-positive (ER+) breast cancer in premenopausal women that interrupts ER signaling. As tumors with elevated heterogeneity, amounts of ER-negative (ER−) cells are present in ER+ breast cancer that cannot be directly killed by TAM. Despite complete remissions have been achieved in clinical practice, the mechanism underlying the elimination of ER− cells during TAM treatment remains an open issue. Herein, we deciphered the elimination of ER− cells in TAM treatment from the perspective of the bystander effect. Markable reductions were observed in tumorigenesis of ER− breast cancer cells by applying both supernatants from TAM-treated ER+ cells and a transwell co-culture system, validating the presence of a TAM-induced bystander effect. The major antitumor protein derived from ER+ cells, peptidyl-prolyl cis-trans isomerase B (PPIB), is the mediator of the TAM-induced bystander effect identified by quantitative proteomics. The attenuation of ER− cells was attributed to activated BiP/eIF2α/CHOP axis and promoted endoplasmic reticulum stress (ERS)-induced apoptosis, which can also be triggered by PPIB independently. Altogether, our study revealed a novel TAM-induced bystander effect in TAM treatment of ER+ breast cancer, raising the possibility of developing PPIB as a synergistic antitumor agent or even substitute endocrine therapy.
Identification of structural and regulatory cell-shape determinants in Haloferax volcanii
Authors: Schiller Heather , Hong Yirui , Kouassi Joshua , Rados Theopi , Kwak Jasmin , DiLucido Anthony , Safer Daniel , Marchfelder Anita , Pfeiffer Friedhelm , Bisson Alexandre , Schulze Stefan , Pohlschroder Mechthild 
Published: February 2024

AbstractArchaea play indispensable roles in global biogeochemical cycles, yet many crucial cellular processes, including cell-shape determination, are poorly understood. Haloferax volcanii, a model haloarchaeon, forms rods and disks, depending on growth conditions. Here, we used a combination of iterative proteomics, genetics, and live-cell imaging to identify mutants that only form rods or disks. We compared the proteomes of the mutants with wild-type cells across growth phases, thereby distinguishing between protein abundance changes specific to cell shape and those related to growth phases. The results identified a diverse set of proteins, including predicted transporters, transducers, signaling components, and transcriptional regulators, as important for cell-shape determination. Through phenotypic characterization of deletion strains, we established that rod-determining factor A (RdfA) and disk-determining factor A (DdfA) are required for the formation of rods and disks, respectively. We also identified structural proteins, including an actin homolog that plays a role in disk-shape morphogenesis, which we named volactin. Using live-cell imaging, we determined volactin’s cellular localization and showed its dynamic polymerization and depolymerization. Our results provide insights into archaeal cell-shape determination, with possible implications for understanding the evolution of cell morphology regulation across domains.