bluuebunny/crossref_metadata_2025_split huggingface dataset:
MELANOMA: UMA ANÁLISE ABRANGENTE
Authors: Barcala Natália da Silva , Narracci Felipe , Perillo Gabriel Martins , Corredato Júlia Cauneto Banheti , Fonsatti Lilian Mariano , Sampaio Francielli Elaine de Araújo , Bueno Lorraine da Rosa , Britto Luiz Eduardo Gomes de , Castilhos Ana Laura Macias , Domingues Sabrina Picin , Ataides Ágatha Ianka da Silva , Nascimento Bianca Vilela , Rodrigues Vitória Mendonça , Péres Júnior Ronaldo Rogério , Paulik Kamilla Ferreira , Coelho Ana Julia Koehler Guedes 
Published: December 2023

O melanoma é uma neoplasia cutânea maligna originada nos melanócitos, células responsáveis pela produção de melanina. Este tipo de câncer de pele tem a capacidade de se disseminar rapidamente para outros órgãos, o que pode resultar em complicações sérias. A dermatoscopia, biópsia cutânea e tomografia por emissão de pósitrons são técnicas essenciais para o diagnóstico precoce e estadiamento do melanoma. O tratamento do melanoma envolve uma abordagem multidisciplinar, incorporando cirurgia, imunoterapia, terapia-alvo e radioterapia, conforme a extensão da doença. Avanços notáveis incluem inibidores de checkpoint imunológico, como ipilimumabe e pembrolizumabe, que demonstraram eficácia significativa em melanomas avançados. A prevenção do melanoma é fundamentada na conscientização sobre fatores de risco, como exposição excessiva ao sol, e programas de rastreamento dermatológico em populações de alto risco. A compreensão molecular do melanoma, incluindo mutações em genes como BRAF, tem contribuído para estratégias de tratamento mais personalizadas. Em suma, o melanoma representa um desafio clínico significativo, exigindo uma abordagem integrada que abrange desde técnicas diagnósticas avançadas até terapias inovadoras, com ênfase na prevenção e conscientização.
Assessment of physical functioning in rheumatoid arthritis patients after rituximab therapy using health assessment questionnaire-disability index
Authors: Anna Maria Joy , Shaji Akshara , Mathew Shaniya , Abraham Suja 
Published: December 2023

The most frequently used instrument for measuring self-reported physical function in rheumatoid arthritis is the health assessment questionnaire – disability index. The objective of this study was to assess the effects of treatment with rituximab on patient-reported outcomes in severe rheumatoid arthritis patients. Rituximab was initiated in RA-diagnosed patients who experienced treatment failure or decreased response on the administration of conventional disease-modifying anti-rheumatic drugs. Treatment response after 1g of rituximab infusion was assessed at <6 months and > 6 months follow-up period using patient-reported outcome measure tools and laboratory investigations. Functional ability was evaluated using a questionnaire and the overall disability index was calculated. It was found that all patients achieved minimum clinically important difference(>0.2) from baseline HAQ value within 6 months of rituximab. Assessment of the functional ability demonstrated that the majority of the patients experienced significant improvement in all domains of HAQ-DI after rituximab administration. Patient global assessment shared a moderate correlation with almost all domains of HAQ-DI. Physical function as measured by HAQ-DI showed clinically meaningful improvement within 1 year of rituximab therapy. It has proven to be a safer and more effective treatment option when compared to conventional disease-modifying antirheumatic drugs and has also helped in achieving better responses at a faster pace.
Comparative Insilico Docking Study Involving Antagonistic Activity of CoumarinDerivatives on EGFR and CDK2
Authors: Thomas Riya Ann , Sunil Eva Sara , Fernandez Anna Abel , Anil Soorya , Antony Anjana , Davis Ann Maria , Thomas Godwin , T S Saranya , Sreeram Greeshma , Abraham P Elizabeth 
Published: December 2023

Epidemiological evidence suggests that about 25% of cancer occurs due to chronic inflammation, thus it is clear that cancer and inflammation are related. Piroxicam is the one of the drug that is used in the treatment of both cancer and inflammation, but it is having some side effects like constipation, blurring of vision ,skin rashes etc. Coumarin is having both anti-inflammatory and anti-cancer activity so the purpose of this study is to screen the best target among EGFR and CDK2. Docking analysis was carried out using AutoDock4. From the study it was found that EGFR showed better result compare to CDK2. Also methyl substitution at 8th position and chlorine substitution at 5th position of coumarin showed better activity than standard drug piroxicam and phytoconsitutents isofraxidin andscopoletin.
Formulation and evaluation of herbal aftershave gel
Authors: Francis Celu Mariya , George Riya , Sankar Anaswara , J Ancy I , Mathews Manju Maria , R Badmanaban 
Published: December 2023

Aftershave gels are cosmetic products that may often contain alcohol which is an antiseptic agent to prevent infection of cuts, as well as to act as an astringent to reduce skin irritation. However, alcohol-based aftershave gels may be prone to cause burns or irritations. The main aim of the present study is to formulate and evaluate aftershave gel with reduced alcohol content using Hemigraphis colorata extract. The Hemigraphis colorata plant possesses wound healing and anti-inflammatory actions. Ethanol was used as solvent for the extraction in our present study. The gel formulation F0 was made according to the conventional formula having 50% alcohol content. The second formulation F1 was the one that contains three fourth of the alcohol of the above formulation. The final gel F2 was the one with three-fourths of the quantity of alcohol mentioned in the conventional formula and having Hemigraphis colorata extract in the concentration 50mg/ml. Gels were evaluated for pH, viscosity, and anti-bacterial properties. From the studies conducted it was concluded that the formulation used Hemigraphis colorata extracts showed better antimicrobial activity than the conventional “alcohol-only” formulation. So, from the study it can be concluded that plant would be a promising candidate to be used in an aftershave preparation, provided it exhibits astringent activity also.
Cosmetic use related adverse events and need for cosmetovigilance
Authors: Joseph Merrin , Shaji Karishma , T M Mahin , P B Nandana , Das Krishna 
Published: December 2023

Cosmetics are applied to human body for cleansing, beautifying, promoting attractiveness or altering appearance. Cosmetics are causing adverse events to users, yet evidence about its magnitude is limited among students due self-diagnosis and self-medication .To know about the cosmetic use related adverse events and to enhance awareness regarding cosmetovigilance among the students of Nirmala College of pharmacy, Muvattupuzha by an educational intervention. To assess the prevalence of cosmetics, use among the students of Nirmala college of pharmacy, Muvattupuzha.To identify the cosmetics related adverse events and knowledge , To improve the awareness regarding cosmetovigilance. By online survey using google form. The questionnaire consisted of three parts, demographic profile, utilization pattern, participant's experience of cosmetics-related adverse reactions for the last two years.an awareness program about cosmetovigilance system. Access the knowledge of students one month after awareness.502 participants,55.2% with pimple ,55.2% with hair loss,41.4% with allergic reaction, dryness of skin, etc.
TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KEFARMASIAN DI RSUD UMAR MAS’UD BAWEAN
Authors: Salniyah  , Nurul Faizah  , Amrina Amalia Yogananda  
Published: December 2023

RSUD Umar Mas’ud Bawean merupakan salah satu rumah sakit pilihan masyarakat Bawean untuk berobat. Pelayanan kefarmasian merupakan bagian yang tidak terpisahkan dari sistem pelayanan kesehatan yang berperan penting dalam meningkatkan mutu kehidupan pasien. Penelitian ini bertujuan untuk mengetahui karakteristik responden di RSUD Umar Mas’ud Bawean, gambaran pelayanan kefarmasian di RSUD Umar Mas’ud Bawean, dan tingkat kepuasan pasien terhadap pelayanan kefarmasian di RSUD Umar Mas’ud Bawean. Penelitian ini termasuk penelitian non eksperimental dengan analisis kuantitatif menggunakan model SERVQUAL dengan perhitungan CSI (Customer Satisfaction Index) dan menggunakan skala likert dengan lima dimensi yaitu reliability, responsiveness, assurance, empathy dan tangible.
Hasil penelitian karakteristik responden, menunjukkan bahwa jenis kelamin yang paling banyak adalah wanita (76%), usia terbanyak 15-24 tahun (42%), tingkat pendidikan tertinggi adalah tamatan SMA (43%), dan pekerjaan terbanyak adalah ibu rumah tangga (32%). Gambaran pelayanan kefarmasian di RSUD Umar Mas’ud Bawean pada dimensi reliability cukup puas 2,6%, puas 55,4%, dan sangat puas 42%. Pada dimensi responsiveness cukup puas 3%, puas 49,25%, dan sangat puas 47,75%. Pada dimensi assurance tidak puas 0,2%, cukup puas 1,4%, puas 50,2%, dan sangat puas 48,2%. Pada dimensi empathy tidak puas 0,2%, cukup puas 1,6%, puas 47,8%, dan sangat puas 50,4%. Pada dimensi tangibles cukup puas 3,5%, puas 45,6%, dan sangat puas 51,2%.
Hasil skor kepuasan pasien dengan perhitungan CSI (Customer Satisfaction Index) sebesar 89,68 yang berarti pasien merasa sangat puas terhadap pelayanan kefarmasian di RSUD Umar Mas’ud Bawean.
The peculiarities for structural analysis of strength and stiffness of floating docks with the long span overhead-type cranes
Authors: Жестков К.Г. , Шахнов М.А. 
Published: December 2023

В статье представлены основные требования к облику крытого стального плавучего дока, а также к конструкции большепролетных мостовых кранов и их подкрановому основанию. Рассмотрен спектр нагрузок при эксплуатации дока, определяющий особенности расчетного обоснования прочности и жесткости конструкций. Выполнено адаптирование нормативной базы для опорного основания мостовых кранов морского исполнения. Разработаны и внедрены конструктивные мероприятия по условиям размещения на плавучем доке кранового пути для двухбалочных мостовых кранов опорного типа. Выполнено расчетное обоснование прочности и жесткости плавучего сооружения в целом на основе единой конечно-элементной (КЭ) расчетной модели дока с крышей. Обеспечена работоспособность большепролетных мостовых кранов морского исполнения и многопролетных неразрезных подкрановых конструкций с часто установленными опорами при помощи расчетных КЭ подмоделей.
In the paper there are represented the general requirements for structural design of covered floating dock from steel, long span overhead-type cranes and their runway foundation. The spectrum of the force and kinematic loads was considered. It defines some peculiarities for structural analysis of strength and stiffness of a floating dock in operation. Adaptation the rules of regulations for a marine design of the crane runway foundation was performed. The structural improvements, based on restrictions of runway layout, were developed and introduced for the double span overhead-type crane carried by runway rails in floating dock. The analytical substantiation of strength and stiffness of covered floating dock was done by means of the uniform finite element (FE) model. Reliability of the marine overhead-type cranes and the multispan continuous gantry girders, which supported by frequently installed runway columns, was validated using FE submodeling.
Methodological foundations and results of practical application of the software package for modeling the rolling of the vessel on the PSPD
Authors: Смирнов Ю.А. , Тряскин В.Н. , Иванова Д.Т. , Булкин В.А. , Левошкин А.К. 
Published: December 2023

В тезисах доклада обсуждается методика накатки судна на подъемно-спусковой плавучий док (ПСПД) при наличии одной или двух опор. Отмечены причины, обуславливающие отсутствие специальной универсальной методики, содержащей обстоятельные рекомендации для разработки проектов передаточных плавучих доков и моделирования процесса накатки судна на док при различных условия докования. Рассмотрены этапы процесса накатки судна. Указаны, что перед проведением операции накатки судна, производится предварительная балластировка дока для обеспечения равновесной посадки на ровный киль за счет принятия: балласта, выравнивающего крен и дифферент; балласта, замещающего массу судна; балласта на всплытие с опор. Предполагается, что к моменту начала накатки, док располагается на опорах. В соответствующие отсеки принято необходимое количество прижимного, сгонного и маневренного балласта. Определены допускаемые нагрузки на опоры, предельно допускаемая величина изгибающего момента от общего продольного изгиба дока, допускаемые величины прогибов корпуса дока в реперных (контрольных) точках. Сформулированы общая последовательность действий и расчетных обоснований - общий алгоритм, который может быть заложен в основу автоматизированной системы для управления процессом накатки судна на док. Представлены результаты компьютерного моделирования накатки судна при наличии двух опор береговой и мористой и только одной береговой опоры на существующий ПСПД.
The abstract discusses the methodology of bumping a vessel on a transfer floating dock (TLFD) in the presence of one or two supports. The reasons are noted, which cause absence of special universal technique, containing detailed recommendations for development of projects of transfer floating docks and modeling of the process of ship bumping on a dock at various conditions of docking. The stages of ship rolling process are considered. It is specified that before vessel rolling operation, preliminary ballasting of dock is carried out to provide equilibrium landing on an even keel by means of: ballast to level the roll and trim; ballast to replace the vessel mass; ballast for surfacing from the supports. It is assumed that by the time the rolling starts, the dock is positioned on the supports. Necessary amount of clamping, run-in and maneuvering ballast is taken into the corresponding compartments. Permissible loads on the supports, maximum permissible value of bending moment from total longitudinal bending of the dock, permissible values of deflections of the dock hull at reference (control) points are determined. A general sequence of actions and computational justifications is formulated. It is a general algorithm, which can be the basis for an automated system for controlling the process of ship bending on the dock. Results of computer simulation of ship bumping at presence of two shore and bridge supports and only one shore support on the existing RAP are presented.
Application of the neural network method to determination of the physical and mechanical properties of composite materials
Authors: Коршунов В.А. , Кузнецова В.Н. , Мудрик Р.С. , Пономарев Д.А. , Родионов А.А. 
Published: December 2023

Рассматриваются процедуры понижения размерности задачи определения упругих характеристик композитных материалов различной структуры. В качестве исходного варианта принят полный метод расчета, базирующийся на использовании модели представительного элемента объема (ПЭО-модели). Расчет параметров напряженно-деформированного состояния и определение упругих характеристик ПЭО-модели реализованы с помощью метода конечных элементов. Отмечены особенности создания ПЭО-модели и задания граничных условий, определяющих периодичность структуры композиционного материала. Рассмотрены варианты ПЭО-моделей для материала с волокнистой структурой и с дискретными включениями. Представлен алгоритм получения упругих параметров материала и дана оценка временных затрат на его реализацию. Редуцирование размерности задачи выполнено с помощью нейросетевых моделей путем построения нейронной регрессионной сети ПЭО. Для реализации нейронной сети собрана обучающая выборка путем решения большого количества тестовых задач с использованием полного метода. Обучение сети проведено на основе алгоритма оптимизации, реализованного на языке Python. Для каждого из рассмотренных вариантов ПЭО-модели определены весовые коэффициенты. Выполнена оценка погрешности нейронной сети.
The procedures for reducing the dimensionality of the problem of determining the elastic characteristics of composite materials of various structures are considered. A complete calculation method based on the usage of a representative volume element model (RVE-model) was adopted as an initial variant. Calculation of the parameters of the stress-strain state and determination of the elastic characteristics of the RVE model are implemented using the finite element method. The features of creating a RVE model and setting boundary conditions that determine the periodicity of the composite material structure are noted. Variants of RVE models for a material with a fibrous structure and with discrete inclusions are considered. An algorithm for obtaining elastic parameters of the material is presented and an estimate of the time spent on its implementation is given. Reducing the dimension of the problem was performed using neural network models by constructing a neural regression network of RVE. To implement a neural network, a training sample was collected by solving a large number of test problems using the full method. The training of the network was carried out on the basis of an optimization algorithm implemented in Python. Weight coefficients are determined for each of the considered variants of the RVE model. The estimation of the error of the neural network is performed.
Application of numerical methods to brittle fracture modeling
Authors: Коршунов В.А. , Мащенко А.В. , Мудрик Р.С. , Пономарев Д.А. , Родионов А.А. 
Published: December 2023

Рассмотрено решение задачи о хрупком разрушении с помощью численных процедур метода конечных элементов. Задача актуальна для решения проблемы форм разрушения конструкций и для проблемы внешних воздействий ледовых образований на морские инженерные сооружения. Повышение эффективности решения задачи о разрушении обеспечено использованием расчетных процедур, адаптированных для учета процессов, происходящих в материале и конструкции в процессе разрушения. В работе исследованы три процедуры распространения хрупких трещин в рамках МКЭ: адаптивное перестроение сетки конечных элементов; специальные конечные элементы, с эффектом раскрытия трещины и введение специальной сцепляющей зоны по границам конечных элементов, где возможно продвижение трещины. Эффективность процедур проверена при примере хрупкого разрушения трехмерного ледового образца в форме параллелепипеда на трехточечный изгиб. Проведен анализ чувствительности при варьировании характерного для каждой процедуры параметра разрушения. Результаты расчета сопоставлены с экспериментальными данными. Выполнен сравнительный анализ рассмотренных процедур по точности полученных результатов, по эффективности получения решения и по трудоемкости реализации.
The solution of the brittle fracture problem with the help of numerical procedures of the finite element method is considered. The task is relevant for solving the problem of structural failure forms and for the problem of external impacts of ice formations on marine engineering structures. Improving the efficiency of solving the problem of destruction is provided by the use of calculation procedures adapted to account for the processes occurring in the material and structure during the destruction process. In this paper, three procedures for the propagation of brittle cracks in the framework of FEM are investigated: adaptive rearrangement of the finite element grid; special finite elements, with the effect of crack opening and the introduction of a special coupling zone along the boundaries of the finite elements, where it is possible to advance the crack. The effectiveness of the procedures was tested by the example of brittle fracture of a three-dimensional ice sample in the form of a parallelepiped to a three-point bend. Sensitivity analysis was carried out when varying the destruction parameter characteristic of each procedure. The calculation results are compared with experimental data. A comparative analysis of the considered procedures is carried out on the accuracy of the results obtained, on the effectiveness of obtaining a solution and on the complexity of implementation.
Numerical modeling of ice mechanical behavior under quasi-static and dynamic loads
Authors: Родионов А.А. , Рябушкин С.В. 
Published: December 2023

Представлена математическая модель деформирования и разрушения льда в широком диапазоне внешних воздействий. Модель основана на методе сглаженных частиц Галёркина (SPG) и современных подходах механики повреждаемых сред. В качестве модели материала для льда используется модель динамического разрушения Джонсона-Холмквиста. В рамках единой модели выполнено численное моделирование квазистатического (скорость 1 мм/с) и динамического (скорость 10 м/с) сжатия ледовых образцов. Результаты численного моделирования находятся в согласии с экспериментальными наблюдениями. Представлены подходы к учету факторов, напрямую влияющих на прочностные характеристики ледовых образований – скорость деформации, гидростатическое давление, а также температура, пористость и соленость – в рамках единой вычислительной модели. Рассмотрены возможности сопряжения бессеточного метода Галеркина с классическими сеточными методами механики сплошной среды с целью моделирования взаимодействия льда с конструкциями и сооружениями. В настоящее время в задачах ледовой механики численное моделирование практически не применяется, а существующие традиционные методы не могут описать комплексное поведение льда, особенно при высоких скоростях деформаций. В этой связи построение и реализация подобного рода моделей является необходимым условием для эффективного решения задач прикладной механики льда, соответствующих современному уровню развития численных методов и соответствующих вычислительных возможностей.
A mathematical model of ice deformation and destruction under a wide range of external influences is presented. The model is based on the Smoothed Particle Galerkin method (SPG) and the recent approaches of damageable medium mechanics. The Johnson-Holmquist damage model is used as the material model for ice. Numerical modeling of quasi-static (velocity 1 mm/s) and dynamic (velocity 10 m/s) ice samples compression was performed within the unified numerical model. The numerical simulation results are in a good agreement with the experimental observations. The influence of the main factors affecting the ice strength characteristics – strain rate, pressure, temperature, porosity and salinity – is considered. Coupling between the SPG and the standard mesh methods of continuum mechanics in order to simulate ice-structure interaction is proposed and discussed. At present, numerical modeling in ice mechanics problems is practically not used. Meanwhile the existing traditional methods cannot fully simulate the complex ice behavior, especially at high strain rates. Thus, the development of this kind of models is a necessary condition in order to solve ice mechanics problems effectively. The instruments applied correspond to the most recent numerical methods and computational capabilities.