bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between Size of Myocardial Infarctions Assessed by Delayed Contrast‐Enhanced MRI after Primary PCI, Biochemical Markers, and Time to Intervention
Authors: HAASE JÜRGEN , BAYAR RUSEN , HACKENBROCH MATTHIAS , STÖRGER HANS , HOFMANN MANFRED , SCHWARZ CLAUS‐EBERHARD , REINEMER HARALD , SCHWARZ FRANZ , RUEF JOHANNES , SOMMER TORSTEN 
Published: November 2004

Background The quantitative assessment of myocardial infarctions using delayed contrast‐enhanced magnetic resonance imaging (MRI) has recently been validated using postmortem histopathological animal studies. In a prospective study, we investigated the correlation between infarct size as assessed by delayed contrast‐enhanced MRI, elevation of creatine kinase (CK), and c‐reactive protein (CRP) as well as the time from onset of symptoms to intervention.
Methods Four to 10 days after immediate PCI in 45 acute ST‐segment elevation myocardial infarction (STEMI) patients (<24 hour) with stenting of the infarct‐related artery and treatment with abciximab, we performed gadolinium contrast‐enhanced three‐dimensional inversion recovery gradient‐echo MR sequences with complete coverage of the LV‐myocardium in short‐axis slices. The mass of infarcted tissue based on the volume of hyperenhanced myocardium was calculated and linear regression analysis was performed to assess the correlation between absolute size of infarctions (g) as well as relative size (LV%) with peak values of CK, CRP, and the time to PCI.
Results There was a significant correlation between absolute size of infarctions (g) and peak CK values (r = 0.72; P < 0.001) as well as the relative size (LV%) and peak CK (r = 0.77; P < 0.001). No correlations were found between absolute size (r = 0.33) as well as relative size (r = 0.27) of infarctions and peak CRP. There was also no correlation between absolute (r = 0.29) as well as relative size of infarctions (r = 0.27) and the time from onset of symptoms to PCI.
Conclusions In patients with acute STEMI (<24 hour) undergoing immediate PCI with stenting and treatment with abciximab, peak CK values correlated well with infarct size as assessed by delayed contrast‐enhanced MRI. There were no correlations between infarct size and peak CRP as well as the time to intervention.
Influence of Doxycycline on Clinical and Angiographic Outcome Following Percutaneous Coronary Intervention
Authors: KANNENGIESSER MATTHIAS , KALTENBACH MARTIN , STILLE WOLFGANG , REIFART NICOLAUS , HAASE JÜRGEN 
Published: November 2004

Background: Infection with Chlamydia pneumoniae may be involved in atherosclerosis. Neointima proliferation after percutaneous coronary intervention (PCI) could be aggravated by proinflammatory action of chronic vascular chlamydial infection. We investigated the influence of doxycycline therapy on restenosis rate and adverse clinical event rates after PCI.
Methods: We followed 1,019 consecutive patients in a single center nonrandomized observational study. During a 3‐month period, all patients having PCI (n = 541; treatment group) received oral doxycycline 100 mg/day for 50 days starting from the day of the procedure. A control group (n = 478) consisted of consecutive post‐PCI patients recruited from immediately preceding (n = 250) and ensuing periods. Event rates were gained by questionnaires after 259 ± 57 days. Restenosis rate was derived from the routine angiographic restudies after 172 ± 15 days.
Results: No significant differences between treatment and control group were found in adverse clinical event rates (myocardial infarction: 0.7% vs 1.3%; repeat‐PCI: 24.0% vs 20.9%; coronary bypass grafting: 5% vs 3.9%; overall death after 6 months: 3.5% vs 2.1%) and overall restenosis rate (21.6% vs 23.4%). A subgroup analysis of nondiabetic male smokers revealed a lower restenosis rate in the treatment group (10.9% vs 30.9%; P = 0.0195).
Conclusion: Doxycycline therapy for 50 days following PCI does not appear to have a substantial influence on the clinical and angiographic outcome in unselected patients. The observed reduction in restenosis rate among nondiabetic male smokers defines a new hypothesis that should stimulate further investigations.
A multivariate study of predictors of repeat parasuicide
Authors: Colman I. , Newman S. C. , Schopflocher D. , Bland R. C. , Dyck R. J. 
Published: November 2004

Objective:  To identify variables which differentiate future repeaters of parasuicide from non‐repeaters in a multivariate analysis.Method:  Interviews were conducted with 507 parasuicide cases; data were collected on precipitating factors for the index parasuicide, psychiatric and medical history, stressful life events, prior history of parasuicide, hopelessness, anger, self‐esteem and social adjustment. Individuals were followed for 1–2 years to determine if a repeat parasuicide occurred.Results:  A logistic regression model identified four significant predictors of repeat parasuicide: prior history of parasuicide, a history of depression, a history of schizophrenia and poor physical health. A risk factor scale constructed from these four variables showed that the risk of repeat parasuicide increases as the number of risk factors increases.Conclusion:  This study identifies four key predictors of repeat parasuicide, and provides evidence that the risk of repeat parasuicide increases when multiple risk factors are present.
A clinical investigation of the morphological changes in the posterior mandible when implant‐retained overdentures are used
Authors: Blum Igor R. , McCord J. Fraser 
Published: November 2004

AbstractObjectives: The widespread use and broad acceptance of osseointegrated dental implants as a means of retaining and supporting mandibular overdentures provide potentially stable three‐dimensional reference structures, which have been used to examine the morphological changes of the surface contours of the mandibular ridges distal to implants. Unlike traditional methods that tended to measure changes in ridge morphology and quantity radiographically, this prospective study investigated the changes in the sagittal surface contours of the posterior residual ridges over a 1‐year period by an alternative, non‐radiographic method using serial casts of residual ridges of a group of patients.Material and methods: The residual ridges of the serial casts produced were examined using a profiling apparatus and computer software programs that allowed the orientation, digitised recording and measurement of the sagittal surface contours of the posterior residual ridges of mandibular casts in terms of area (cm2).Results: Statistical analysis revealed that the detected reductive changes in the surface contour of the posterior residual ridges following the wearing of an implant‐retained mandibular overdenture over a 1‐year period were highly significant (P<0.001).Conclusion: It is concluded that the methodology presented in this study can be used reliably as an alternative to radiographical examination for detecting changes that occur in the distal residual alveolar ridges of the implant containing edentulous mandible when implant‐retained overdentures are used. Thus, the method presented may be used to contribute to a reduced exposure to ionising radiation for patients wearing implant‐retained overdentures.
A systematic review of the survival and complication rates of fixed partial dentures (FPDs) after an observation period of at least 5 years
Authors: Lang Niklaus P. , Pjetursson Bjarni E. , Tan Ken , Brägger Urs , Egger Matthias , Zwahlen Marcel 
Published: November 2004

AbstractObjectives: The objective of this systematic review was to assess the 5‐ and 10‐year survival of combined tooth–implant‐supported fixed partial dentures (FPDs) and the incidence of biological and technical complications.Methods: An electronic MEDLINE search supplemented by manual searching was conducted to identify prospective and retrospective cohort studies on FPDs with a mean follow‐up time of at least 5 years. Patients had to have been examined clinically at the follow‐up visit. Assessment of the identified studies and data abstraction was performed independently by two reviewers. Failure and complication rates were analyzed using random‐effects Poisson regression models to obtain summary estimates of 5‐ and 10‐year survival proportions.Results: From a total of 3844 titles and 560 abstracts, 176 articles were selected for full‐text analysis, and 13 studies met the inclusion criteria. Meta‐analysis of these studies indicated an estimated survival of implants in combined tooth–implant‐supported FPDs of 90.1% (95 percent confidence interval (95% CI): 82.4–94.5%) after 5 and 82.1% (95% CI: 55.8–93.6%) after 10 years. The survival rate of FPDs was 94.1% (95% CI: 90.2–96.5%) after 5 and 77.8% (95% CI: 66.4–85.7%) after 10 years of function. There was no significant difference in survival of tooth and implant abutments in combined tooth–implant FPDs. After an observation period of 5 years, 3.2% (95% CI: 1.5–7.2%) of the abutment teeth and 3.4% (95% CI: 2.2–5.3%) of the functionally loaded implants were lost. After 10 years, the corresponding proportions were 10.6% (95% CI: 3.5–23.1%) for the abutment teeth and 15.6% (95% CI: 6.5–29.5%) for the implants. After a 5 year observation period, intrusion was detected in 5.2% (95% CI: 2–13.3%) of the abutment teeth. Intrusion of abutment teeth were almost exclusively detected among non‐rigid connections.Conclusion: Survival rates of both implants and reconstructions in combined tooth–implant‐supported FPDs were lower than those reported for solely implant‐supported FPDs (Pjetursson et al. 2004). Hence, planning of prosthetic rehabilitation may preferentially include solely implant‐supported FPDs. However, anatomical aspects, patient centered issues and risk assessments of the residual dentition may still justify combined tooth–implant‐supported reconstructions.It was evident from the present search that tooth–implant‐supported FPDs have not been studied to any great extent and hence, there is a definitive need for more longitudinal studies examining these reconstructions.
Relative effects of pre‐ and post‐eruption water fluoride on caries experience by surface type of permanent first molars
Authors: Singh Kiran A. , Spencer A. John 
Published: November 2004

Abstract – Objectives:  To determine the relative pre‐ and post‐eruption exposure effects of fluoridated water on the caries experience of different surface types of first permanent molars.Methods:  Parental questionnaires covering residential history of participants were linked to the oral examinations of 6–15‐year‐old Australian children conducted in 1992 by the School Dental Services of South Australia and Queensland. Percentage of lifetime exposed to optimally fluoridated water pre‐ (PRE) and post‐eruption (POST) was calculated with respect to tooth eruption age. Combined pre‐ and post‐eruption categories were created to test PRE against POST exposure: PRE and POST = 0, PRE < POST, PRE = POST and in the range 0–90% of lifetime exposure, PRE > POST and, PRE and POST ≥ 90% lifetime exposure. These categories were used as indicator variables in linear regression models with PRE and POST = 0 as reference in an analysis of first permanent molar DMFS scores overall and by surface type.Results:  Participation rates were 69.7% in South Australia (n = 9690) and 55.6% in Queensland (n = 10 195). Compared with the reference, the categories PRE > POST (β = −0.033), PRE = POST (β = −0.028) in the range 0–90% and, PRE and POST ≥ 90% (β = −0.055) showed significantly lower caries overall (P < 0.01), with a similar pattern for pit and fissure surface caries (β = −0.035, −0.031 and −0.052, respectively). Only a high PRE and POST exposure decreased caries levels significantly in the approximal (β = −0.038; P < 0.01) and free smooth surfaces (β = −0.023; P = 0.03).Conclusions:  Pre‐eruption exposure was important for a caries preventive effect on first permanent molars in children 6–15 years old since post‐eruption exposure alone could not lower caries levels significantly. For pit and fissure surfaces, a high pre‐eruption exposure could decrease caries levels significantly. However, for other surface types, only a high pre‐ and post‐eruption exposure produced a caries preventive effect.
Influence of Thyroid Autoimmunity and Maternal Age on the Risk of Miscarriage
Authors: Sieiro Netto Lino , Medina Coeli Claudia , Micmacher Eduardo , Mamede Da Costa Sheila , Nazar Luiz , Galvão Daut , Buescu Alexandru , Vaisman Mario 
Published: November 2004

Objectives:  Recently, studies have shown an association between antiperoxidase for the detection of thyroid autoimmunity (TAI) and abortion. Another point to be considered is the association of high risk of abortion and maternal age. The aim of the present study was to evaluate if the association between TAI and miscarriage could also be verified whether a population of unselected pregnant young women who normally present a low risk of miscarriage.Materials and methods:  We studied 534 pregnant women, by determining their serum thyroid antiperoxidase antibodies (TPO‐Abs), thyrotropin (TSH) and free thyroxine (fT4) levels. Our end point was the pregnancy loss or live birth.Results:  Age ranged from 12 to 49 years (mean ± S.D.; 23.5 ± 5.9). Of 534 women, 29 (5.4%) were TPO‐Ab positive. TSH levels were significantly higher in TPO‐Ab‐positive women compared with TPO‐Ab negative women (median; 1.9 versus 1.1; P = 0.001). Elevated TSH levels were found in 13.8% (4 of 29) of the TPO‐Ab‐positive women compared with only 2.4% (12 of 505) in the TPO‐Ab‐negative women. There were no significant differences in fT4 levels in relation with autoimmunity and risk of miscarriage. The overall risk of miscarriage was 2.4% (13 of 534). Risk of miscarriage was significantly higher among women older than 35 years (7.7%), TPO‐Ab positive (10.3%) and presenting high levels of TSH (12.5%). These factors remained independently associated with the risk of miscarriage in full multivariate analysis.Conclusions:  We conclude that TAI is independently associated with is a higher risk of miscarriage in a population of unselected pregnant presenting a low risk of miscarriage.
Antichlamydial and Antisperm Antibodies in Patients with Chlamydial Infections
Authors: Dimitrova Dimitrina , Kalaydjiev Svetoslav , Hristov Lyubomir , Nikolov Krasimir , Boyadjiev Todor , Nakov Lyudmil 
Published: November 2004

Problem:  Establishing the correlation between antichlamydial antibodies (AchAbs) and antisperm antibodies (ASA) in patients with chlamydial infections.Method of study:  ASA were studied in sera from patients (142 with genital, 57 with ocular chlamydial infections) and control group (n = 100) by gelatin and tray agglutination test (TAT), sperm immobilization test (SIT) and ELISA. AchAbs were revealed by ELISA.Results:  A significantly higher (P < 0.05) ASA incidence was noted in patients with genital infections as compared with controls and patients with ophthalmologic infection (P < 0.0001), but not between patients with ophthalmologic infection and controls (P > 0.05). A significant correlation was established between AchAbs and ASA for TAT (r = 0.8214, P = 0.0341), SIT (r = 0.797, P = 0.032) and ELISA (r = 0.8519, P = 0.0313) in patients with genital infections only.Conclusions:  The genital Chlamydia infection may play a role in the induction of ASA. This is probably a result of the inflammatory process, but not of cross‐reactivity between sperm and Chlamydia trachomatis antigens.
Possible Pathophysiological Roles of Mitogen‐Activated Protein Kinases (MAPKs) in Endometriosis
Authors: Yoshino Osamu , Osuga Yutaka , Hirota Yasushi , Koga Kaori , Hirata Tetsuya , Harada Miyuki , Morimoto Chieko , Yano Tetsu , Nishii Osamu , Tsutsumi Osamu , Taketani Yuji 
Published: November 2004

Problem:  Endometriosis accompanies local inflammatory reactions in the peritoneal cavity. We examined the phosphorylation of mitogen‐activated protein kinases (MAPKs), i.e. extracellular signal‐regulated kinase (ERK), p38 MAPK (p38) and c‐Jun N‐terminal kinase (JNK) in endometriotic stromal cells, and their possible pathophysiological roles in endometriosis in relation to proinflammatory substances.Method of study:  Endometriotic stromal cells were isolated from endometriomas and were cultured for the experiments. Phosphorylation of MAPKs in endometriotic stromal cells treated with interleukin (IL)‐1β, tumor necrosis factor (TNF)α and H2O2 were examined by Western blot analysis. Effects of PD98059, SB202190 and SP600125 (inhibitors of ERK, p38 and JNK, respectively) on IL‐1β‐induced secretion of IL‐6 and IL‐8, and on IL‐1β‐induced expression of cyclo‐oxygenase‐2 (COX‐2) in endometriotic cells were studied. In addition, eutopic endometrial tissues were collected, and the phosphorylation rate of p38 in eutopic endometrial tissues and endometriotic tissues were determined.Results:  IL‐1β, TNFα and H2O2 stimulated the phosphorylation of ERK, p38 and JNK, while the total amounts of proteins of the respective MAPKs were virtually the same compared with those in the unstimulated controls. Both SB202190 and SP600125 suppressed IL‐1β‐induced secretion of IL‐6 and IL‐8, and PD98059 suppressed IL‐1β‐induced secretion of IL‐8. Both SB202190 and PD98059 suppressed IL‐1β‐induced expression of COX‐2 in endometriotic cells. The p38 phosphorylation rates in the endometriotic tissues were significantly higher than those in the eutopic endometrial tissues of the same patients.Conclusions:  Given the current theory that inflammatory changes are involved in the progression of endometriosis, MAPKs could play as pivotal intracellular signal transducers in endometriotic cells, and thus have a pathophysiological role in the disease.
Reduction of gingival recession following orthodontic intrusion in periodontally compromised patients
Authors: Re S. , Cardaropoli D. , Abundo R. , Corrente G. 
Published: November 2004

Structured AbstractAuthors – Re S, Cardaropoli D, Abundo R, Corrente GObjectives – To evaluate the role of orthodontic intrusion and alignment in the reduction of gingival recession (REC) around maxillary incisors of adult periodontal patients.Design – Prospective clinical study.Setting and Sample Population – Twenty‐eight consecutively treated adult patients, suffering from severe chronic periodontitis and with one upper central incisor extruded and infrabony defect on its mesial site. All patients were seen in a private practice in Turin, Italy. At baseline, all patients presented with REC on the buccal and mesial aspects of the treated teeth.Measurements and Results – For each patient probing pocket depth (PPD) and REC were assessed at baseline, at the end of treatment and 1‐year after the end of treatment. REC was also evaluated independently in patients with narrow (NPB) or wide periodontal biotype (WPB). All parameters showed improvement between initial and final measurements statistically, and showed no changes between final and follow‐up measurements. Mean mesial PPD decrease was 4.29 mm, with a residual PPD of 2.50 mm. Mean REC reduction was 0.96 mm on the buccal sites and 1.71 mm on the mesial. No statistical difference was recorded on REC values between groups NPB and WPB.Conclusion – The presented clinical protocol resulted in improvement of all parameters examined. At the end of orthodontic treatment a predictable reduction of REC was reported, both in patients with thin or wide gingiva.
Jaw muscles in older overdenture patients
Authors: Newton James P. , McManus Frank C. , Menhenick Stephen 
Published: November 2004

Objective:  To determine, using computer tomography (CT), whether the retention of a small number of teeth in the older adult used to support overdentures could affect the cross‐sectional area (CSA) and X‐ray density of two jaw closing muscles.Design:  Cross‐sectional study of a group of older patients subdivided into dentate, edentulous and those wearing overdentures supported by two to five teeth.Subjects:  The sample consisted of 24 subjects aged 55–68 years.Outcome measures:  CSA and X‐ray density of two jaw closing muscles, masseter and medial pterygoid were measured and evaluated using CT.Results:  There were no significant differences between left and right jaw muscles, but the CSA of the masseter muscles were significantly larger than the medial pterygoid muscles. The CSA of the masseter and medial pterygoid muscles was significantly smaller in edentulous subjects compared with dentate subjects but no significant difference was observed between subjects wearing overdentures and those with a natural dentition. No significant differences were observed with the X‐ray density between different muscles or dental states.Conclusion:  The retention of a small number of teeth in the older adult used to support overdentures appears to sustain the CSA of two jaw closing muscles and therefore could enhance these patients’ masticatory ability compared with those who were edentulous.
Oral health and reduction in respiratory capacity in a cohort of community‐dwelling elderly people: a population‐based 5‐year follow‐up study
Authors: Hämäläinen Piia , Suominen Harri , Keskinen Marja , Meurman Jukka H. 
Published: November 2004

Objectives:  Several anaerobic bacteria originating in periodontal pockets have been isolated from infected lungs and pharyngeal microflora. Increased bacterial load in lungs is known to be a risk factor for decline in forced expiratory volume during the first second. The aim was to evaluate both cross‐sectionally and longitudinally the association between oral health status and forced expiratory volume during the first second (FEV1) in older residents of the city of Jyväskylä, Finland.Design:  Cross‐sectional and prospective cohort study over a 5‐year follow‐up.Setting:  Research laboratory of the University of Jyväskylä.Participants:  In 1990 dental status and FEV1 were examined in 203 80‐year‐old people, of whom 88 survivors were retested 5 years later.Main outcome measures:  Primary: dental status and FEV1. Secondary: existence of pulmonary diseases, height, handgrip strength, smoking, and length of education.Results:  Participants were regrouped into three categories according to their baseline oral health status. At baseline, men with complete prostheses had the lowest FEV1. Five years later the greatest reduction in FEV1 was seen in subjects with poor periodontal status or complete prostheses (−9.4%) while those with healthy periodontal status showed no reduction in FEV1 values (+1.0%, p = 0.006).Conclusions:  Periodontal infections and complete prostheses may be reservoirs for pathogens which may be harmful and partly explain the observed reduction in FEV1 during ageing.