bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myxoid liposarcoma: treatment outcomes, metastatic pattern and volumetric analysis
Authors: Potkrajcic Vlatko , Zschiegner Merle , Niyazi Maximilian , Warm Verena , Thiel Johannes Tobias , Frantz Sandra , Deinzer Christoph K. W. , Szelat Franziska , Hoffmann Elgin , Paulsen Frank , Eckert Franziska 
Published: February 2025

Abstract

Background
Myxoid liposarcoma (MLPS) is a rare subtype of soft tissue sarcoma. This entity has a specific clinical behavior, characterized with a distinct pattern of hematogenous spread, as well as with a unique radiosensitivity and chemosensitivity. Oncologic results, metastatic patterns and treatment response after multimodal therapy were evaluated in a unicentric patient cohort.

Methods
Patients with myxoid liposarcoma were retrospectively analyzed in a single institution analysis (n = 31). Oncologic outcomes were evaluated in 28 patients with localized MLPS treated with multimodal therapy in curative intent. Metastatic pattern was analyzed in additional 3 patients with initially metastatic disease. In patients treated with concomitant MR-guided hyperthermia in the preoperative setting (n = 7), tumor size response was evaluated longitudinally during radio(-chemo)therapy in thermometry MRIs and before surgery (based on preoperative imaging).

Results
The median follow-up was 4.1 ± 1.0 years. The most common anatomic localization was the lower extremity (78.6%). The 5‑year rates for oncologic outcomes in 28 patients treated in curative intent were 91.7% (± 8.0%) for overall survival (OS), 77.4% (± 11.0%) for local control (LC), 60.1% (± 10.6%) for distant metastasis-free survival (DMFS) and 55.4% (± 11.1%) for disease free survival (DFS). Excellent 5‑year LC (94.7 ± 5.1%) was demonstrated for the cohort excluding 5 patients treated for local recurrences. Most patients had good pathologic response (< 10% vital tumor tissue) following neoadjuvant treatment (82.4%, 14/17). However, this did not correlate with oncologic outcomes. A specific pattern of distant metastases has been observed, with predilection for soft tissues as the most common metastatic site. Furthermore, no isolated pulmonary metastases were observed. The MR analysis demonstrated a significant tumor size reduction (≥ 25%) of the initial tumor volume in 85.7% (n = 6/7) patients. No local recurrences and no distant metastases were observed in patients with significant MR size reduction.

Conclusion
Sequential MRIs during preoperative radiotherapy of myxoid liposarcoma show distinct patterns of the known size reduction of this specific subentity. Our analysis of metastatic patterns demonstrate mostly soft tissue metastases, no patient experienced isolated pulmonary metastases.
Misconceptions about intimate partner violence risk assessment algorithm in the Basque Country: a reply to Valdivia, Hyde-Vaamonde, and García-Marcos (2024)
Authors: Loinaz Ismael 
Published: February 2025

Abstract
Violence risk assessment is an internationally recognised methodology, aimed to manage different forms of violence. Most risk assessment tools, as is the case of the reviewed one, are designed to protect victims in the context of pressure, little time, or little information. This paper presents a reply to Valdivia et al. (AI & Society, July 2024) criticism of the algorithm for intimate partner violence risk assessment—EPV—used in the Basque Country. They concluded that more than 50% of high-risk victims are in danger, using results from a pilot version of the instrument, not the reviewed one published in 2010, nor the system in use since May 2013. In addition, qualitative information from a single professional generates global criticisms of the tool. Neither the current cut-off points nor the real weighting of the items nor the real risk management procedure are considered, and the personal opinion of a judge is assumed to be better than the use of tools when the accumulated research shows the opposite. When EPV risk assessment reports are used in courts, they may only temporarily affect some perpetrator rights, imposing restraining orders or, in the worst case, pretrial prison waiting for sentence. However, risk management can save the life of the victim. Cautions and suggestions related to the judicial context, such as improving risk reports or training judicial professionals, are shared. However, Valdivia et al.’s paper leads to misconceptions that extend to different sectors when echoing the wrong conclusions of their paper.
Requirements for fast multianalyte detection and characterisation via electrochemical-assisted SERS in a reusable and easily manufactured flow cell
Authors: Blaha Maximilian E. , Das Anish , Belder Detlev 
Published: February 2025

Abstract
Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive analytical technique that captures vibrational spectra of analytes adsorbed to rough coin metal surfaces with remarkable signal intensities. However, its wider application is limited by challenges in substrate range, quantification, and the disposable nature of SERS substrates partly due to irreversible analyte adsorption—commonly referred to as the ‘memory effect’. Overcoming these limitations and achieving real-time analysis in flow-through systems remains a key challenge for the advancement of SERS. This study presents a SERS flow cell incorporating an Ag-based SERS substrate and a Pt counter-electrode, enabling the investigation of how electrochemical methods can address existing challenges. Our approach demonstrates that signal intensities can be both enhanced and spectroelectrochemically modified. Additionally, the combination of constant solvent flow and electrochemical potentials enhances the longevity of the SERS substrate, facilitating multianalyte measurements while mitigating the memory effect. Key parameters have been systematically studied, including SERS substrate materials (silver and copper), solvents, buffers, supporting electrolytes, and electrochemical protocols. We achieved consistent and reproducible electrochemical tuning of SERS signals by using halogen-free electrolytes in polar solvents commonly used in techniques like HPLC. The versatility of the system was validated through the analysis of several model compounds and the sequential detection of multiple analytes. We also successfully applied the system to detect and characterise contaminants and pharmaceuticals, highlighting its potential for a wide range of analytical applications.

Graphical Abstract
Comparative study of outcomes with total knee arthroplasty: medial pivot prosthesis vs posterior stabilized implant. Prospective randomized control
Authors: Obada Bogdan , Iliescu Madalina Gabriela , Costea Dan Ovidiu , Petcu Lucian , Popescu Andrei Ion 
Published: February 2025

Abstract

Purpose
Total knee arthroplasty (TKA) is an effective procedure for pain relief and restoration of function in patients with symptomatic end-stage knee arthritis. Kinematic problems due to conventional implant design have been postulated. The objective of this study is to determine if there was any difference in postoperative ROM and outcomes between patients undergoing MP-TKA vs PS-TKA.

Methods
We prospectively colected the records of 600 consecutive patients with TKA performed by six senior orthopaedic surgeons between 2017 - 2021. We compared the ROM and patient-reported outcomes (Western Ontario McMaster Osteoarthritis Index WOMAC, Oxford Knee Score OKS, Knee Society Score KSS, Forgotten Joint Score FJS) between MP TKA and PS TKA.

Results
There were no specific criteria for implant selection as the two groups were consecutive cohorts of patients and implant selection depended on surgeon preference. Demographics, comorbidities, diagnosis and severity of osteoarthritis were similar between MP and PS groups. The trend for OKS in our study is the same in both groups, but with higher mean values in the MP group. The trend of WOMAC pain, stiffness and disability score is the same in both groups, but with higher mean values in the PS group at one year and two years. KSS clinical and functional score is the same in both groups, but with higher mean values in the MP group. The most important score is forgetten joint score which is favourable for the MP group.

Conclusion
The patients who underwent the MP-TKA scored better than those who underwent the PS-TKA, particularly regarding deep knee flexion and stability of the prosthesis. This may be related to better replication of natural knee kinematics with MP-TKA.
Coral reef thermal microclimates mapped from the International Space Station
Authors: Longenecker J. , Benzoni F. , Dunn N. , Fox H. E. , Gleason A. , Otis D. , Chirayath V. , Oury N. , Purkis S. J. 
Published: February 2025

Abstract
Satellite sea surface temperature (SST) is critical for describing marine environments. Traditional SST data, such as those provided by the Group for High Resolution Sea Surface Temperature (GHRSST) program, are valuable, but have a relatively coarse spatial resolution for mapping coral reef thermal environments. Hence, fine resolution SST from orbit would be of great utility to the coral reef research community and speed the pathway to an increased understanding of how, when, and where thermal stress afflicts individual reefs. Such data would support adaptive management, especially so for the design of marine protected areas. Flying aboard the International Space Station, the NASA ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) instrument may already fill this niche with a spatial resolution 204 times finer than GHRSST. To evaluate ECOSTRESS thermal data over reef environments, we deployed 21 temperature loggers over three years across two reef sites in the Red Sea. We compared temperature retrievals from both the coarse resolution GHRSST and the fine resolution, experimental, ECOSTRESS, to this in-situ logger dataset. While temperature data from both orbital platforms correlated strongly with the logger recordings, only ECOSTRESS, with its 70-m pixels, could construct thermal microclimate maps capturing the dynamic temperature fluctuations experienced by our studied reefs. We contend that ECOSTRESS represents a significant advancement in the capability to monitor heat stress on reefs from orbit.
A critical review of medicolegal research and information asymmetries in investigating cases of extrajudicial executions and forced disappearances
Authors: Dempsey Nicholas , Sarkar Reena , Rivera Claudia , Bassed Richard 
Published: February 2025

Abstract
Medicolegal systems investigate the cause and manner of death, particularly differentiating between unintentional and intentional deaths. The examination of remains from unlawfully killed individuals is critical in exposing human rights violations. However, forensic medical investigations of these human remains can face multiple challenges, especially in contexts marked by limited resources, political influence, and sub-optimal investigative procedures. When killings are state-sanctioned or facilitated by well-resourced non-state actors, the clandestine disposal of remains can create a culture of impunity, leaving affected families and communities without recourse or resolution. This study aggregates articles in English and Spanish, examining the current state of how forensic medical research on extrajudicial executions and forced disappearances informs practice. It highlights critical gaps in the empirical literature, particularly in the reporting of the scientific findings that impact the investigation of victims of these unlawful killings. These cases' inherently non-linear and unpredictable nature, often influenced by chaotic and unstable conditions, can create disproportionate challenges for forensics practitioners. To address these gaps, this review suggests leveraging epidemiological frameworks to track data trends in these unlawful killings, supporting public health initiatives in prevention and policy. It emphasises the need for comprehensive documentation, robust databases, and adaptive forensic methodologies to navigate uncertainties and systemic limitations inherent in this complex and unpredictable domain of medicolegal death investigation.
Socio-demographic and toxicological findings from autoptic cases in a Northern Italy community (2017–2022)
Authors: Palazzoli Federica , Filippini Tommaso , Lavenia Antonino , Balduini Simone , Attanasi Alessia , Verri Patrizia , Vandelli Daniele , Castagnetti Valentina , Santunione Anna Laura , Vinceti Marco , Cecchi Rossana 
Published: February 2025

Abstract

Introduction
The overall trend in the use of licit and illicit substances is increasing. However, a few data on socio-demographic and toxicological findings in post-mortem cases are available.

Methods
A retrospective study was conducted on autoptic cases evaluated in the Institute of Legal Medicine of the cities of Modena and Reggio Emilia in the period 2017–2022. Positivity to toxicological compounds and their relation with sociodemographic and forensic features were evaluated.

Results
A toxicological analysis was conducted in 504 cases out of 794 autopsies, finding 330 positive cases. An association was observed between positivity and increasing age, as well as manner of death. The most frequently observed classes of substances were benzodiazepine (41.2%), followed by alcohol (35.5%) and abuse drugs (24.8%). For every class of substances in at least half of the cases two or more classes were detected. As regards prescribed drugs, approximately 40% of cases assumed 2 or more drugs, while polypharmacy occurred in 6.1%.

Conclusions
Older age and specific causes of deaths appear to be associated with toxicological findings. In addition, co-assumption of licit and illicit substances emerged as a widespread phenomenon in our study population. Under a public health perspective, these data provide findings of relevance for preventive and therapeutic measures.
Common mycorrhizal networks improve survival and mediate facilitative plant interactions among Andropogon gerardii seedlings under drought stress
Authors: Russell Margaret , Řezáčová Veronika , Miller Kirby Shane , Nardi Wynter Helene , Brown Morgan , Weremijewicz Joanna 
Published: February 2025

Abstract
Under drought conditions, arbuscular mycorrhizal (AM) fungi may improve plant performance by facilitating the movement of water through extensive hyphal networks. When these networks interconnect neighboring plants in common mycorrhizal networks (CMNs), CMNs are likely to partition water among many individuals. The consequences of CMN-mediated water movement for plant interactions, however, are largely unknown. We set out to examine CMN-mediated interactions among Andropogon gerardii seedlings in a target-plant pot experiment, with watering (watered or long-term drought) and CMN status (intact or severed) as treatments. Intact CMNs improved the survival of seedlings under drought stress and mediated positive, facilitative plant interactions in both watering treatments. Watering increased mycorrhizal colonization rates and improved P uptake, particularly for large individuals. Under drought conditions, improved access to water most likely benefited neighboring plants interacting across CMNs. CMNs appear to have provided the most limiting resource within each treatment, whether P, water, or both, thereby improving survival and growth. Neighbors near large, photosynthate-fixing target plants likely benefited from their establishment of extensive hyphal networks that could access water and dissolved P within soil micropores. In plant communities, CMNs may be vital during drought, which is expected to increase in frequency, intensity, and length with climate change.
Early evaluation and treatment of thoracolumbar kyphosis in children with achondroplasia
Authors: Omara Chady , Pieters Lynn , Castelein René M. , Sakkers Ralph J. B. , Vleggeert-Lankamp Carmen L. A. 
Published: February 2025

Abstract

Purpose
Thoracolumbar kyphosis (TLK) is frequently reported in children with achondroplasia. The combination of TLK and the narrow spinal canal in achondroplasia increases the risk of developing symptomatic spinal stenosis. However, there is no consensus on the optimal management of TLK.

Methods
This retrospective cohort study evaluated children under four years old with achondroplasia, monitoring TLK every six months. Pathologic TLK was defined as a Cobb angle of 20 degrees or more between T10 and L2. Management involved either a wait-and-see policy, which prohibited unsupported sitting, or bracing. Surgery was reserved for severe progressive TLK or spinal stenosis cases. TLK was evaluated over time. A receiver operating characteristic curve determined the baseline threshold where wait-and-see management failed to resolve TLK below 20 degrees. Multiple linear regression compared bracing versus wait-and-see management for cases exceeding 40 degrees.

Results
Sixty-two patients were included, with a median age of 10 months and a median follow-up of 31 months. TLK prevalence decreased from 85% at baseline to 42% at final follow-up. The mean Cobb angle decreased from 31 ± 11 degrees to 22 ± 16 degrees (p < 0.001). The threshold for ineffective wait-and-see management was identified as 33 degrees. Bracing resulted in significantly more TLK reduction than wait-and-see management for cases exceeding 40 degrees (15 degree difference, 95% CI 2–28, p = 0.023). Three patients required surgery.

Conclusion
TLK is highly prevalent in achondroplasia, necessitating careful monitoring. A wait-and-see policy with restrictions on unsupported sitting is recommended initially, but early bracing should be considered for more severe cases.
Clinical implementation of the 3D 4K exoscope (Orbeye™) in reconstructive head and neck surgery
Authors: Hofmann Elena , Doll Christian , Koerdt Steffen , Kurth Cynthia , Heiland Max , Kreutzer Kilian 
Published: February 2025

Abstract

Purpose
To assess the clinical utility of the 3D 4K exoscope for reconstructive head and neck surgery.

Methods
This retrospective study analyzed surgical details and complications with the use of the 3D 4K exoscope for microvascular reconstruction at a high-volume Department of Oral and Maxillofacial Surgery, compared to the use of a 2D microscope. Patients with oral cancer undergoing microvascular reconstruction were categorized into two cohorts based on the intraoperative use of the 3D 4K exoscope (Orbeye™, Olympus, Tokyo, Japan) or a conventional microscope (ZEISS S8 – OPMI Vario, Carl Zeiss AG, Oberkochen, Germany; Leica M680, Leica Mikrosysteme Vertrieb GmbH, Wetzlar, Germany) during a six-month study period, respectively. Outcomes were also compared between two time periods of the exoscope use to assess the learning curve over time.

Results
The exoscope was applied for microvascular anastomosis in 55 surgical cases (cohort 1), and the conventional microscope was employed in 56 cases (cohort 2). The rates of postoperative complications within 14 days following the use of the exoscope were 14.5% (N = 8), compared to 16.1% (N = 9) in cohort 2. Analysis over time demonstrated a learning curve with the exoscope, reflected in a decrease in postoperative complications within 14 days from 22.7 to 9.1%.

Conclusion
The three-dimensional camera system provides excellent and reliable intraoperative visualization in reconstructive head and neck surgery. Transitioning to this new technology did not lead to an increase in intra- or postoperative complications, but the successful implementation requires some experience with the device.
Unearthing the nexus: latifundia, earthquakes, and the emergence of the Sicilian Mafia
Authors: Battisti Michele , Bernardo Giovanni , Kourtellos Andros , Lavezzi Andrea Mario 
Published: February 2025

Abstract
This paper explores the historical origins of the Mafia and its roots in the Sicilian latifundia. By employing earthquake intensity as an instrumental variable to tackle endogeneity concerns, our study reveals a significant relationship between the presence of the Mafia during its initial historical appearances in the second half of the 19th century and the characteristics of latifundia. Latifundia, distinguished by large landowners and extensive agriculture, including the rotation of single-crop, pasture, and fallow lands, is found to be closely linked to this heightened Mafia presence. Moreover, our analysis rules out contemporary socio-economic factors by considering a set of control variables such as agricultural proxies. These findings highlight a persistent historical pattern of inequality, proxied by the spread of latifundia, underscoring the enduring influence of the medieval feudal system, transformed into latifundia, on social dynamics. Our findings suggest that policies aimed at reducing the concentration of land ownership and promoting land reform could effectively have curbed the emergence of organized crime in areas with a history of comparatively higher land ownership inequality.
Human identification through panoramic dental radiographs: a novel matching approach
Authors: Bozkurt Mustafa Hakan , Karagol Serap , Omezli Mehmet Melih 
Published: February 2025

Abstract
Biometric person identification systems identify individuals using personal characteristics such as fingerprints, eyes or facial recognition. However, in some critical situations, such as fires, serious traffic accidents, earthquakes or serious injuries, these features can become ineffective. In certain situations, dental characteristics may become the only valid biometric feature for identification. In these cases, forensic dentists work by examining dental structures to establish a person's identity. Currently, studies are being carried out to develop an automated recognition system based on computer vision to assist forensic dentists. However, due to the difficulties in processing panoramic X-ray images and challenges in accessing the data, person matching studies with these images are limited. This paper presents a novel method for matching people based on panoramic X-ray images. Dental person recognition studies can proceed either by investigating the similarity of teeth or by examining the similarity of jaws. In this work, a new approach that uses keypoint descriptors to perform tooth-jaw matching is proposed. This approach offers a high match rate by allowing to search for dental features on a jaw-by-jaw basis and requires less computational complexity than tooth-to-tooth matching. Unlike jaw-to-jaw approaches, it is possible to match individual teeth. The method presented in this study provides a novel approach with significant matching accuracy and efficiency. By evaluating the effectiveness of these methods on panoramic images, the study contributes to forensic dental identification methods in scenarios where traditional biometric features may fall short.