bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigasi, strategi, implementasi, dan evaluasi integrasi teknologi informasi dan komunikasi dalam pembelajaran matematika sebagai upaya pengembangan profesionalisme guru matematika SMP
Authors: Taufan Mochammad , Nurafifah Luthfiyati , Sudirman Sudirman , Mellawaty Mellawaty , Ismunandar Denni , Isnawan Muhammad Galang 
Published: February 2024

Pendidikan abad 21 menuntut guru untuk mengintegrasikan teknologi informasi dan komunikasi dalam proses pembalajarannya khususnya pembalajaran matematika. Namun, masih minimnya pelatihan, sosialisasi dan seminar terkait dengan cara mengintegrasikan teknologi informasi dan komunikasi yang valid, praktis dan efektif masih sangat kurang. Oleh karena hal itu, penelitian ini bertujuan menginvestigasi, menyusun strategi, mengimplemtasikan, dan mengevaluasi pelaksanaan pembelajaran daring guru matematika di masa pandemi COVID-19. Subjek penelitian yang terlibat pada penelitian ini adalah calon guru dan guru matematika tingkat sekolah menengah pertama di Kabupaten Indramayu. Alat pengumpulan data yang digunakan dalam penelitian ini yakni (a) lembar observasi; (b) pedoman wawancara; (c) angket; (d) tes evaluasi adopsi teknologi. Sedangkan analisis data yang dilakukan yakni mengumpulkan data, melakukan pengkodean, menganalisis kode, menyajikan data, menyimpulkan dan memverifikasi kesimpulan. Pengolahan data secara kualitatif tersebut dibantu dengan menggunakan software AtlasTi. Hasil penelitian menyimpulkan bahwa (1) Pada tahap investigasi sebagian besar guru menggunakan beberapa aplikasi diantaranya yaitu, Zoom Meeting, YouTube, WhatsApp, PowerPoint, Google Meet, Google Form, Google Drive, Google Classroom, Geogebra dan Blog sekolah. (2) pada tahap strategi, peneliti mengadakan diskusi dan workshop dengan beberapa guru matematika dengan dasar hasil penelitian pada tahap investigasi tentang penggunaan ICT pada pembelajaran matematika serta kesulitan yang dirasakan oleh guru selama pandemi COVID-19. (3) pada tahap implementasi, guru menggunakan aplikasi yang telah dibuat atau yang sudah jadi sebelumnya. Pada tahap ini, langkah awalnya adalah mempersiapkan siswa mengguanakan aplikasi tersebut dengan cara mengarahkan dan membimbing siswa untuk mengubduh (download) aplikasi tersebut serta menjelaskan cara menggunakan media pembelajaran matematika yang berupa aplikasi yang bisa diakses melalui smartphone tersebut. (4) Pada tahap evaluasi, diperoleh kesimpulan bahwa integrasi media pembelajaran matematika berbasis ICT cukup efektif dalam meningkatkan hasil belajar matematika siswa.
Kata Kunci: Integrasi Teknologi Informasi dan Komunikasi; Pembelajaran Matematika; Guru Matematika.
EFEK KONDISI FINANSIAL, STRUKTUR UTANG, DAN CASH HOLDING PADA SENSITIVITAS ARUS KAS INVESTASI
Authors: Faiqoh Dewi , Kustina Lisa , Taftazani Afif Mustafid 
Published: February 2024

This study aims to analyze the adaptation of companies before the pandemic to post-covid-19. Panel data regression with a fixed model. A sample of 30 companies was divided into two categories, namely companies that experienced problems and those that did not. The sampling technique uses purposive sampling analysis method, secondary data, and panel data with the help of the Eviews statistical tool. The results obtained are partially companies with financial condition (X1) and debt structure (X2) have a positive and significant effect on ICFS. cash holding has no effect on ICFS. Simultaneously the results of financial condition (X1), debt structure (X2), and cash holding (X3) affect the investment cash flow sensitivity variable (Y).
Keywords: financial condition, debt structure, cash holding, and investment cash flow sensitivity.
PENGARUH CITRA MEREK TERHADAP PRODUK PRIVATE LABEL
Authors: Putra Maidy Pratama Zazali , Sojanah Janah , Santoso Budi 
Published: February 2024

Bisnis ritel di Indonesia dapat dibedakan menjadi dua kelompok besar, yakni ritel tradisional dan ritel modern. ritel modern memiliki pertumbuhan lebih cepat dibandingkan dengan ritel tradisional. Pertumbuhan jumlah ritel di Indonesia juga diikuti dengan semakin banyaknya produk private label dipasaran. Private label dikenal sebagai merek toko, merek sendiri, merek pengecer, dan merek distributor grosir sendiri. Citra terhadap merek berhubungan dengan sikap yang berupa keyakinan dan preferensi terhadap suatu merek. Konsumen yang memiliki citra yang positif terhadap suatu merek, akan lebih memungkinkan untuk melakukan pembelian. Dalam penelitian ini bagaimana pengaruh citra merek terhadap private label. Penelitian ini menggunakan cross sectional method dengan pendekatan veritikatif deskriptif serta teknik analisis data untuk hipotesis menggunakan analisis regresi linier sederhana. Hasil analisis regresi linier berganda menunjukkan nilai p = 0,000 maka semua pengaruh antar variabel tersebut secara statistik signifikan serta dari hasil uji hipotesis didapat nilai thitung 5.891 > ttabel 2.02439 dan nilai signifikansi 0.000 < nilai probabilitas 0.05. Dari hasil tersebut dapat disimpulkan bahwa dalam penelitian ini citra merek berpengaruh positif signifikan terhadap minat beli, sehingga dapat disimpulkan bahwa citra merek memiliki pengaruh yang positif signifikan terhadap produk private label di indomaret Setiabudhi. Artinya semakin baik citra merek, maka semakin tinggi kemungkinan konsumen berminat membeli produk private label
Creating Millennial Generation Loyalty Through Customer Perceived Value on Halal Local Cosmetic Products
Authors: Immawati Siti Asriah , Jumarno Jumarno , Kasmo Arief Bowo Prayoga , Tafiprios Tafiprios 
Published: February 2024

With the rapid growth of Indonesia's cosmetics industry, the cosmetic industry has the opportunity to compete by making halal labelled products. The aim of this research is to find out how the value the customer considers affects customer loyalty by looking at how satisfied local millennials are with halal cosmetics. This research involves 250 millennials living in Jabodetabek. Using Smart-PLS, data is collected through questionnaires distributed through Google Forms. The results of the analysis show that the value perceived by the customer has a positive and significant impact on the consumer loyalty, the value experienced by the client has a negative and significant effect on consumer satisfaction, and the satisfaction of consumers has a significant and positive effect on the customer loyalty and the average consumer’s satisfaction.
Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin
Authors: Gonçalves Adriana F. , Lima-Pinheiro Ana , Teixeira Miguel , Cassiano Gustavo Capatti , Cravo Pedro , Ferreira Pedro E. 
Published: February 2024

IntroductionMalaria parasites increasingly develop resistance to all drugs available in the market, hampering the goal of reducing malaria burden.MethodsHerein, we evaluated the impact of a single-nucleotide variant, E738K, present in the 26S proteasome regulatory subunit rpn2 gene, identified in Plasmodium chabaudi resistant parasites. Plasmids carrying a functional rpn2 interspecies chimeric gene with 5’ recombination region from P. falciparum and 3’ from P. chabaudi were constructed and transfected into Dd2 P. falciparum parasites.Results and discussionThe 738K variant parasite line presented increased parasite survival when subjected to dihydroartemisinin (DHA), as well as increased chymotrypsin-like activity and decreased accumulation of polyubiquitinated proteins. We thus conclude that the ubiquitin-proteasome pathway, including the 738K variant, play an important role in parasite response to DHA, being the first report of a mutation in a potential DHA drug target enhancing parasite survival and contributing to a significant advance in the understanding the biology of artemisinin resistance.
Lumbar disc herniation is an independent predictor of plaque burden in the patients with unstable angina
Authors: Wang Yongchao , Ge Junhua , Xu Hao , Li Jian 
Published: February 2024

ObjectiveAssessing the impact of lumbar disc herniation (LDH) on the plaque burden of coronary atherosclerosis is our objective.MethodsIn this study, a total of 212 patients (age 46–80 years) with unstable angina (UA) who underwent coronary angiography (CAG) in our hospital from January 2018 to July 2022 due to UA were included. Patients were divided into LDH group (n = 106) and no LDH group (n = 106). Gensini scores were calculated to assess the plaque burden of coronary. Logistic analysis was used to examine potential risk variables linked to the Gensini score. The association between lumbar disc lesions grading and coronary plaque burden was analysed by Spearman's correlation test. LDH patients with higher plaque burden (n = 56) were further divided into evolocumab treatment group (n = 28) and conventional treatment group (n = 28). Cox regression analysis were performed.ResultsPatients with LDH had higher Gensini scores (P &lt; 0.01) and triglyceride (TG) levels (P = 0.04), but HDL-C (P = 0.01) levels were lower. LDH was found to be an independent risk factor for higher Gensini scores (OR = 2.38, P &lt; 0.01) by logistic analysis. The Spearman's correlation test suggested that the degree of lumbar disc lesions was related to the Gensini score and the level of blood lipid. Cox regression analysis showed that evolocumab treatment could significantly reduce the composite MACE events (cardiac death, nonfatal myocardial infarction, nonfatal stroke, and readmission due to angina) (HR = 0.26, P = 0.04) in higher coronary plaque burden patients.ConclusionLDH is an independent risk factor for the higher coronary plaque burden. Evolocumab treatment significantly reduced the occurrence of cardiovascular events in LDH patients with higher plaque burden. Additionally, our data indicate that LDH is associated with increased blood lipid, which may contribute to the development of plaque burden.
Fractional flow reserve measurements and long-term mortality—results from the FLORIDA study
Authors: Boeckling Felicitas , Stähli Barbara E. , Rudolph Tanja , Lutz Matthias , Schatz Anne-Sophie , Vogelmann Tobias , Stueve Magnus , West Nick E. J. , Boone Els , Erbay Aslihan , Leistner David M. 
Published: February 2024

BackgroundRandomized evidence suggested improved outcomes in fractional flow reserve (FFR) guidance of coronary revascularization compared to medical therapy in well-defined patient cohorts. However, the impact of FFR-guided revascularization on long-term outcomes of unselected patients with chronic or acute coronary syndromes (ACS) is unknown.AimsThe FLORIDA (Fractional FLOw Reserve In cardiovascular DiseAses) study sought to investigate outcomes of FFR-guided vs. angiography-guided treatment strategies in a large, real-world cohort.MethodsThis study included patients enrolled into the German InGef Research Database. Patients undergoing coronary angiography between January 2014 and December 2015 were included in the analysis. Eligible patients had at least one inpatient coronary angiogram for suspected coronary artery disease between January 2014 and December 2015. Patients were stratified into FFR arm if a coronary angiography with adjunctive FFR measurement was performed, otherwise into the angiography-only arm. Matching was applied to ensure a balanced distribution of baseline characteristics in the study cohort. Patients were followed for 3 years after index date and primary endpoint was all-cause mortality.ResultsIn the matched population, mortality at 3 years was 9.6% in the FFR-assessed group and 12.6% in the angiography-only group (p = 0.002), corresponding to a 24% relative risk reduction with use of FFR. This effect was most pronounced in patients in whom revascularization was deferred based on FFR (8.7% vs. 12.3%, p = 0.04) and in high-risk subgroups including patients aged ≥75 years (14.9% vs. 20.1%, p &lt; 0.01) and those presenting with ACS (10.2% vs. 14.0%, p = 0.04).ConclusionsFFR-based revascularization strategy was associated with reduced mortality at 3 years. These findings further support the use of FFR in everyday clinical practice.
Serum amyloid beta 42 levels correlated with metabolic syndrome and its components
Authors: Li Kecheng , Zhou Xiaoli , Liu Youren , Li Dongyu , Li Yinyin , Zhang Ting , Fu Chunyan , Li Lin , Hu Yang , Jiang Li 
Published: February 2024

IntroductionBeta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer’s disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-β peptides is due to an imbalance between their production and elimination. Previous studies show that diminished levels of CSF amyloid beta 42 (Aβ42) is a biomarker in AD; however, the role of serum Aβ42 in AD is contradictory. BMI and obesity have been reported to be related to increased serum Aβ42 levels. Therefore, we aimed to investigate the relation between metabolic syndrome (MetS), its clinical measures (abdominal obesity, high glucose, high triglyceride, low high-density lipoprotein cholesterol level, and hypertension), and serum Aβ42 levels.MethodsA total of 1261 subjects, aged 18–89 years in Chengdu, China, were enrolled from January 2020 to January 2021 to explore the correlation of serum Aβ42 levels with body mass index (BMI), blood lipids, and blood pressure. Furthermore, as the risk of MetS is closely related to age, 1,212 participants (N = 49 with age ≥ 80 years old were excluded) were analyzed for the correlation of serum Aβ42 level and MetS clinical measures.ResultsThe results showed that log-transformed serum Aβ42 level was positively correlated with BMI (R = 0.29; p &lt; 0.001), log-transformed triglyceride (R = 0.14; p &lt; 0.001), and diastolic blood pressure (DBP) (R = 0.12; p &lt; 0.001) and negatively correlated with high-density lipoprotein (HDL-c) (R = −0.18; p &lt; 0.001). After adjusting for age, sex, and other covariates, elevated serum Aβ42 level was correlated with higher values of BMI (βmodel1 = 2.694, βmodel2 = 2.703) and DBP (βmodel1 = 0.541, βmodel2 = 0.546) but a lower level of HDL-c (βmodel2 = −1.741). Furthermore, serum Aβ42 level was positively correlated with MetS and its clinical measures, including BMI and DBP, and negatively correlated with HDL-c level in the Han Chinese population. However, the level of serum Aβ42 did not show a significant correlation with high glucose or high triglyceride.DiscussionThese observations indicate that MetS and its components are associated with higher levels of serum Aβ42 and hence limit the potential of serum Aβ42 as a suitable diagnostic biomarker for AD. As such, we recommend serum Aβ42 serve as a direct risk biomarker for MetS rather than for AD.
Comprehensive transcriptomic analysis unveils the interplay of mRNA and LncRNA expression in shaping collagen organization and skin development in Dezhou donkeys
Authors: Wang Xinrui , Peng Yongdong , Liang Huili , Zahoor Khan Muhammad , Ren Wei , Huang Bingjian , Chen Yinghui , Xing Shishuai , Zhan Yandong , Wang Changfa 
Published: February 2024

The primary focus of donkey hide gelatin processing lies in the dermal layer of donkey hide due to its abundant collagen content. However, the molecular mechanism involved in collagen organization and skin development in donkey skin tissue across various developmental stages remains incomplete. The current study aims to investigate the transcriptomic screening of lncRNAs and mRNA associated with skin development and collagen organization across different ages in Dezhou donkeys’ skin. In the pursuit of this objective, we used nine skin tissue samples obtained from Dezhou donkeys at various ages including 8-month fetal stage, followed by 2 and 8 years. RNA-seq analysis was performed for the transcriptomic profiling of differentially expressed genes (DEGs) and lncRNAs associated with skin development in different age groups. Our investigation revealed the presence of 6,582, 6,455, and 405 differentially expressed genes and 654, 789, and 29 differentially expressed LncRNAs within the skin tissues of Dezhou donkeys when comparing young donkeys (YD) vs. middle-aged donkeys (MD), YD vs. old donkeys (OD), and MD vs. OD, respectively. Furthermore, we identified Collagen Type I Alpha 1 Chain (COL1A1), Collagen Type III Alpha 1 Chain (COL3A1), and Collagen Type VI Alpha 5 Chain (COL6A5) as key genes involved in collagen synthesis, with COL1A1 being subject to cis-regulation by several differentially expressed LncRNAs, including ENSEAST00005041187, ENSEAST00005038497, and MSTRG.17248.1, among others. Interestingly, collagen organizational and skin development linked pathways including Protein digestion and absorption, metabolic pathways, Phosphatidylinositol 3-Kinase-Protein Kinase B signaling pathway (PI3K-Akt signaling pathway), Extracellular Matrix-Receptor Interaction (ECM-receptor interaction), and Relaxin signaling were also reported across different age groups in Dezhou donkey skin. These findings enhance our comprehension of the molecular mechanisms underlying Dezhou donkey skin development and collagen biosynthesis and organization, thus furnishing a solid theoretical foundation for future research endeavors in this domain.
Case report: Preimplantation genetic testing for infantile GM1 gangliosidosis
Authors: Zagaynova Valeria A. , Nasykhova Yulia A. , Tonyan Ziravard N. , Danilova Maria M. , Dvoynova Natalya M. , Lazareva Tatyana E. , Ivashchenko Tatyana E. , Shabanova Elena S. , Krikheli Inna O. , Lesik Elena A. , Bespalova Olesya N. , Kogan Igor Yu. , Glotov Andrey S. 
Published: February 2024

Ganglioside-monosialic acid (GM1) gangliosidosis (ICD-10: E75.1; OMIM: 230500, 230600, 230650) is a rare autosomal recessive hereditary disease, lysosomal storage disorder caused by mutations in the GLB1 gene that lead to the absence or insufficiency of β-galactosidase. In this study, we report a case of a Russian family with a history of GM1 gangliosidosis. The family had a child who, from the age of 6 months, experienced a gradual loss of developmental skills, marked by muscle flaccidity, psychomotor retardation, hepatosplenomegaly, and the onset of tonic seizures by the age of 8 months. Funduscopic examination revealed a «cherry red spot» in the macula, which is crucial for the diagnosis of lipid storage disorders. To find the pathogenic variants responsible for these clinical symptoms, the next-generation sequencing approach was used. The analysis revealed two variants in the heterozygous state: a frameshift variant c.699delG (rs1452318343, ClinVar ID 928700) in exon 6 and a missense variant c.809A&gt;C (rs371546950, ClinVar ID 198727) in exon 8 of the GLB1 gene. The spouses were advised to plan the pregnancy with assisted reproductive technology (ART), followed by preimplantation genetic testing for monogenic disorder (PGT-M) on the embryos. Trophectoderm biopsy was performed on 8 out of 10 resulting embryos at the blastocyst stage. To perform PGT-M, we developed a novel testing system, allowing for direct analysis of disease-causing mutations, as well as haplotype analysis based on the study of polymorphic markers—short tandem repeats (STR), located upstream and downstream of the GLB1 gene. The results showed that four embryos were heterozygous carriers of pathogenic variants in the GLB1 gene (#1, 2, 5, 8). Two embryos had a compound heterozygous genotype (#3, 4), while the embryos #7 and 9 did not carry disease-causing alleles of the GLB1 gene. The embryo #7 without pathogenic variants was transferred after consideration of its morphology and growth rate. Prenatal diagnosis in the first trimester showed the absence of the variants analyzed in the GLB1 gene in the fetus. The pregnancy resulted in the delivery of a female infant who did not inherit the disease-causing variants in the GLB1 gene.
Effects of 5-aminolevulinic acid photodynamic therapy for cervical low-grade squamous intraepithelial lesions with HR-HPV infections
Authors: Li Yu , Chen Jing , Hu Yan , Xu Qingyang , Jiang Rongzhen , Teng Yincheng , Xu Yanli , Ma Li 
Published: February 2024

ObjectiveTo determine the effectiveness and safety of 5-aminolevulinic acid mediated photodynamic therapy (5-ALA PDT) in HR-HPV infected patients with cervical low-grade squamous intraepithelial lesions (LSIL) and to explore possible factors affecting treatment outcomes.MethodsThis retrospective study included 96 patients with histologically confirmed cervical LSIL and high-risk human papillomavirus (HR-HPV) infection. They received 5-ALA PDT treatment once a week for a total of 3 courses. All patients were evaluated by cytology tests, HPV DNA assay, colposcopy, and biopsy at 2 weeks, 3 months, and 6 months checkpoint. The chi-square test were used to evaluate the differences in various clinical data, and a p value &lt;0.05 was considered statistically significant.ResultsAt 2 weeks, 3 months, and 6 months checkpoint, colposcopies showed that the cervical iodine-unstained area under VILI (visual inspection with Lugol’s iodine) significantly reduced (p &lt; 0.01) with no structure changes. At 3 months and 6 months checkpoint, the pathological regression rate reached 87.5% (84/96) and 94.79% (91/96), while the HR-HPV clearance rates reached 80.21% (77/96) and 93.75% (90/96) respectively. We also examined the efficacy in the HPV 16/18-related group and non-HPV 16/18-related group. The HR-HPV clearance rate in the HPV16/18 group [94.87% (37/39)] was significantly higher than that of the non-HPV 16/18 group [70.17% (40/57)]. However, at 6 months after treatment, the clearance rate of the HPV 16/18 group [94.87% (37/39)] showed no statistical difference from the non-HPV 16/18 group [92.30% (53/57)].ConclusionTopical 5-ALA PDT can effectively eliminate HR-HPV infection and treat low-grade cervical squamous intraepithelial lesions, it offers an alternative treatment option for patients with LSIL, especially for those with fertility requirements and who wish to preserve cervical structure or function.