bluuebunny/crossref_metadata_2025_split huggingface dataset:
A harvest framework for a recovering American black bear population
Authors: Boudreau Melanie R. , Gantchoff Mariela G. , Conlee Laura , Anderson Charles , Bowersock Nathaniel R. , Belant Jerrold L. , Iglay Raymond B. 
Published: October 2023

AbstractHaving reproducible and transparent science‐based processes in wildlife management ensures the integrity of decision making. These processes are particularly important when establishing harvest frameworks, as guiding information in the peer‐reviewed literature is limited. We provide an example using multiple data sets, whose products guided aspects of the development of a harvest framework for a population of recolonizing American black bears (Ursus americanus) in Missouri, USA. To characterize the spatial distribution of harvest, we used 10 years (2010–2019) of black bear global positioning system (GPS) location data and 30 years (1991–2020) of sightings data to assess spatial vulnerability to harvest as the intersection among information on bear occurrence, bear sightings, and hunter land‐use tendencies (i.e., the avoidance of steep slopes, large distances from roads). We then used the spatial vulnerability assessment, information on the distribution of public and private lands, and easily discernable boundaries (i.e., major highways, rivers) to suggest boundaries for bear management zones. Additionally, to identify the timing of harvest that would limit female harvest bias, we assessed the temporal vulnerability of harvest using sex‐based changes in average daily step lengths and monthly utilization distribution sizes during fall. Black bear occurrence and sighting propensity was greater in southwestern Missouri, and potential hunter land use appeared pervasive across the landscape given the lack of landscape features that would disincentivize use. Given the influence of black bear occurrence and sighting propensity, spatial harvest vulnerability diminished from southern and southeastern to central portions of Missouri, with areas north of the Missouri River not a part of the established black bear range. We consequently divided areas south of the Missouri River into 3 black bear management zones: a small southwestern zone with primarily private lands and high harvest vulnerability, a southeastern zone that encompassed considerable public lands and moderate amounts of vulnerability, and a central zone that was composed mainly of areas of low vulnerability. Temporally, males did not exhibit movement‐based changes, but females became less active after the first week of October and used 63.9% less area through fall. Based on movements rates of males and females, a hunting season after the first week of October could reduce the likelihood of females being harvested. Harvests from the black bear harvest season in 2021 suggest that the proportion of bears harvested in each zone was similar in distribution to the proportion of permits allocated across zones with no harvest sex bias, which was aligned with agency goals. Animal movement and space use data products can guide harvest framework decision‐making.
The effectiveness of ultrasound‐guided injection of BTX‐A in the management of sialorrhea in neurogenic dysphagia patients
Authors: He Zitong , Chen Suling , Zeng Peishan , Dai Meng , Wei Xiaomei , Chen Jiemei , Zhang Xue , Dou Zulin , Wen Hongmei , Li Chao 
Published: October 2023

AbstractObjectiveTo evaluate the effectiveness of ultrasound‐guided injection of botulinum toxin type A (BTX‐A) in treating sialorrhea.MethodsWe recruited 32 sialorrhea subjects and they received an ultrasound‐guided injection of BTX‐A. The extent of salivation was evaluated according to the Visual Analog Scale (VAS), Drooling Severity and Frequency Scale (DSFS), and Saliva Flow Rate (SFR). Laryngeal secretions were evaluated based on Fiberoptic Endoscopic Evaluation of Swallowing (FEES) rated according to the Murray Secretion Scale (MSS). We assessed the extent of salivation and laryngeal secretions before injection and at 1, 2, and 4 weeks after injection.ResultsThe scores for the VAS, DSFS‐S, DSFS‐F, and DSFS‐T decreased significantly at 1, 2, and 4 weeks after injection compared with before injection (p < .05). Based on VAS, the efficacy was substantially higher at 2 and 4 weeks after injection than at 1 week after injection (p < .05). According to DSFS‐S and DSFS‐T, the efficacy was significantly higher at 4 weeks than at 1 week after injection (p < .05). The SFR and MSS scores at 1 and 2 weeks after injection were superior to those before injection (p < .05). Meanwhile, the SFR score 2 weeks after injection was superior to that 1 week after injection (p < .05).ConclusionThe ultrasound‐guided injection of BTX‐A can effectively reduce saliva secretion in patients with neurogenic dysphagia. Furthermore, it has the advantages of early onset time and lasting curative effects, which indicates that clinical promotion and application of this technique are justified.Level of EvidenceLevel 3.
Comparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer
Authors: Lee Yi‐Chan , Lee Li‐Yu , Huang Yenlin , Kao Huang‐Kai , Chang Ya‐Ting , Hung Shao‐Yu , Lu Chuieng‐Yi , Chang Yu‐Sun , Yu Jau‐Song , Chang Kai‐Ping 
Published: October 2023

AbstractObjectivesThis study aimed to investigate the association between salivary matrix metalloproteinase‐1 (MMP‐1) and clinicopathological parameters of oral cavity squamous cell carcinoma (OSCC) and compare the prognostic efficacy of salivary MMP‐1 and other established circulating markers for OSCC.MethodsSaliva specimens from 479 OSCC subjects were examined using an enzyme‐linked immunosorbent assay. The area under the curve (AUC) values of salivary MMP‐1 and other markers were calculated, and survival analyses were conducted using Kaplan–Meier and multivariate regression methods.ResultsSalivary MMP‐1 showed good discrimination in predicting overall survival, with an AUC of 0.638, which was significantly higher than that of albumin (0.530, p = .021) and Charlson comorbidity index (0.568, p = .048) and comparable with neutrophil‐to‐lymphocyte ratio (0.620, p = .987), platelet‐to‐lymphocyte ratio (0.575, p = .125), and squamous cell carcinoma antigen (0.609, p = .605). Elevated levels of salivary MMP‐1 were significantly associated with higher pT classification, pN classification, overall pathological stage, positive extranodal extension, tumor differentiation, positive lymphovascular invasion, positive perineural invasion, and tumor depth (p all <.05). Multivariate analyses indicated that a higher level of salivary MMP‐1 (≥2060.0 pg/mL) was an independent predictive factor of poorer overall survival (adjusted hazard ratio: 1.421 [95% confidential interval: 1.014–1.989], p = .041).ConclusionThe study found that the salivary MMP‐1 level was significantly associated with many adverse clinicopathological parameters of OSCC. In OSCC, it was found to have superior efficacy in predicting prognosis and was an independent prognostic factor of post‐treatment outcome.Level of evidence3.
How social media influencer collaborations are perceived by consumers
Authors: Thomas Veronica L. , Fowler Kendra , Taheran Faegheh 
Published: October 2023

AbstractWithin the social media community, influencers engage in a variety of collaborative practices such as tagging, reposting content from, or forming partnerships with other influencers and brands. While such collaborative efforts are a known practice, less is understood about how influencer collaborations affect consumers' perceptions of the partnering influencers, specifically when a status differential exists within the collaboration. We suggest that such collaborative practices, specifically those where the focal influencer has a higher status than the collaborating partner, may help to weaken consumers' perceptions that the influencer's actions are purely self‐focused. A pilot study, analyzing both influencer–influencer collaborations and influencer–brand collaborations, provides evidence that influencers engage in collaborations with other influencers and brands of different status levels. Two studies then support our theorizing that influencers who collaborate with lower‐status influencers are perceived as less self‐serving and more altruistic, while influencers who collaborate with lower‐status brands are only perceived as less self‐serving. This suggests that, for influencers who desire to enhance how consumers perceive them, an effective strategy is to engage in collaborations with either a lower‐status influencer or brand.
Sustainability‐oriented innovation in retailing
Authors: Gil‐Saura Irene , Ruiz‐Molina Mª Eugenia , Berenguer‐Contrí Gloria , Marín‐García Antonio 
Published: October 2023

AbstractSustainability‐oriented innovation in services has recently been raising interest among academics and professionals. The present research has a dual objective. The first is to develop a scale that captures the notion of sustainability‐oriented innovation in retailing (SOI‐r) from the consumer's perspective. A sequential process is carried out to purge and retain 17 items which synergistically measure SOI‐r. We use quantitative research, adopting an exploratory‐descriptive approach on a total sample of 510 customers of commercial food establishments. The principal axis factor analysis shows six factors: product innovation, marketing innovation, relational innovation, economic sustainability, social sustainability, and environmental sustainability. The second objective is to develop an index using importance‐performance map analysis, which allows analysis of the level of development of the six dimensions identified in SOI‐r and areas for their improvement. The results are compared across food retail formats (hypermarkets, supermarkets, and discount stores) and recommendations are made at a strategic level.
Business cycle effects on consumer behavior: A conceptual framework and research agenda
Authors: Hampson Daniel P. , Xie Yi , Li Weiyi , Kou Sining , Wang Yonggui 
Published: October 2023

AbstractA brand's long‐term success depends on its ability to adapt to changes in the business cycle, during which consumer responses might vary widely. Decades of research on business cycle effects on consumer behavior have led to a diverse, yet scattered body of knowledge. To lay a foundation for moving the field forward, we conduct a semisystematic literature review and differentiate the literature based on (1) behavioral foci studied and (2) underlying theoretical assumptions made. Our review of 55 articles identifies six literature fields that study business cycle effects on consumer behavior, and a multitude of theoretical approaches, which we categorize as mechanical core, affective layer, motivational ground, sociorelational, and cultural background. Next, we integrate commensurable elements of these distinct research traditions in an interdisciplinary, higher‐order conceptual framework of business cycle effects on consumer behavior, underpinned by four fundamental premises that direct marketing practice. Finally, we use these fundamental premises to delineate guidelines that advance the development of business cycle research in marketing, including (but not limited to) focus on consumer well‐being, consumer engagement and digital marketing. The conceptual framework guides the generalizable application of psychological theories to marketing practice during different stages of the business cycle.
Influence of reverted austenite on fatigue life of 18 % nickel maraging steel
Authors: Rohit B. , Rao M N. 
Published: October 2023

AbstractMaraging steels containing 18 % nickel are based on a low‐carbon iron‐nickel‐cobalt‐molybdenum system. These steels demonstrate a remarkable combination of high strength and high toughness. To investigate the effect of overaging and resulting austenite reversion on the fatigue behavior of C250 maraging steel, specimens in the solution annealed state were overaged at 510 °C for various intervals, resulting in volume fractions of reverted austenite ranging from 2.6 % to 11.4 %. The staircase method was used to calculate the fatigue limit. S−N curves were generated by testing a minimum of four stress levels and at least three samples at each stress level. Basquin's equation was used to fit the experimental stress‐life data, and the Basquin exponent and fatigue strength coefficient were calculated. The presence of 2.6 % reverted austenite in the microstructure improved the fatigue limit and fatigue ratio, without significantly reducing tensile strength. The results can be interpreted in terms of reverted austenite having a crack blunting effect on the propagating cracks. A small amount of reverted austenite in the range of 2 %–3 % vol has a beneficial effect on the fatigue life.
Corrosion failure analysis of 20CrMnTi gear in gearbox after oil pressure test
Authors: Lian Z. W. , Fan Z. Y. , He G. N. , Jiang B. , Zhou L. Y. , He F. B. , Liu Y. Z. 
Published: October 2023

AbstractThe causes of corrosion failure of 20CrMnTi rusted gear were analyzed by quantitative analysis of the composition, observation of the microstructure, hardness test and electrochemical test. The microstructure characterization showed that the proportion of retained austenite in the rusted gear was slightly higher and the length‐width ratio of martensite on the surface of addendum of rusted gear was slightly larger than that of the normal gear. However, the corrosion resistance of the rusted gear surface was similar to that of the normal gear. The lubricating oil of the gear was detected to contain water molecules. Further investigation showed that continuous rainy days during the period from installation to disassembly led to a relatively high humidity environment and also the block cover was not installed at that time. Therefore, the corrosive medium continuously entered the gearbox through the block cover hole and destroyed the protection of lubricating oil film, resulting in serious erosion of the gear near the block cover hole. After securing the problem, the block cover was kept installed all the time and no such corrosion failure occurred again.
Optimization of pickling and annealing parameters in cold rolling using the Taguchi method
Authors: Özakın B. 
Published: October 2023

AbstractIn this study, the optimum values of pickling and annealing parameters in cold rolling were obtained by using the Taguchi method. The materials taken from the hot rolling mill were subjected to pickling with different pickling times (3 min, 4 min, 5 min) parameters and then cold rolled. After this process, annealing was carried out with different annealing temperatures (700 °C, 750 °C, 800 °C), annealing times (5 min, 7.5 min, 10 min) in order to eliminate the cold working hardness. After these processes, sheet materials were subjected to skin‐pass rolling, which is the last step of the rolling process. Optimum conditions are minimum rolling force measured from the load cell positioned on the work rolls. In this direction, S/N ratios with objective function “smaller is better” and were calculated and the optimum levels of the parameters were determined as 3 min pickling time, 750 °C annealing temperature and 10 min annealing time. In line with the findings obtained from the analysis of variance, it was determined that the most important parameter was the annealing time with a rate of 48.99 %. Confirmation experiments were carried out and it was concluded that the optimization was valid.
Resistance to abemaciclib is associated with increased metastatic potential and lysosomal protein deregulation in breast cancer cells
Authors: Scheidemann Erin R. , Demas Diane M. , Hou Chunyan , Ma Junfeng , He Wei , Sharma Gaurav , Schultz Eric , Weilbaecher Katherine N. , Shajahan‐Haq Ayesha N. 
Published: October 2023

AbstractCyclin dependent kinase 4 and 6 inhibitors such as abemaciclib are routinely used to treat metastatic estrogen receptor positive (ER+) breast cancer. However, adaptive mechanisms inhibit their effectiveness and allow for disease progression. Using ER+ breast cancer cell models, we show that acquired resistance to abemaciclib is accompanied by increase in metastatic potential. Mass spectrometry‐based proteomics from abemaciclib sensitive and resistant cells showed that lysosomal proteins including CTSD (cathepsin D), cathepsin A and CD68 were significantly increased in resistant cells. Combination of abemaciclib and a lysosomal destabilizer, such as hydroxychloroquine (HCQ) or bafilomycin A1, resensitized resistant cells to abemaciclib. Also, combination of abemaciclib and HCQ decreased migration and invasive potential and increased lysosomal membrane permeability in resistant cells. Prosurvival B cell lymphoma 2 (BCL2) protein levels were elevated in resistant cells, and a triple treatment with abemaciclib, HCQ, and BCL2 inhibitor, venetoclax, significantly inhibited cell growth compared to treatment with abemaciclib and HCQ. Furthermore, resistant cells showed increased levels of Transcription Factor EB (TFEB), a master regulator of lysosomal‐autophagy genes, and siRNA mediated knockdown of TFEB decreased invasion in resistant cells. TFEB was found to be mutated in a subset of invasive human breast cancer samples, and overall survival analysis in ER+, lymph node‐positive breast cancer showed that increased TFEB expression correlated with decreased survival. Collectively, we show that acquired resistance to abemaciclib leads to increased metastatic potential and increased levels of protumorigenic lysosomal proteins. Therefore, the lysosomal pathway could be a therapeutic target in advanced ER+ breast cancer.
The role of CD4+ T cells in tumor and chronic viral immune responses
Authors: Xie Luoyingzi , Fang Jingyi , Yu Juncheng , Zhang Weinan , He Zhiqiang , Ye Lilin , Wang Huaizhi 
Published: October 2023

AbstractImmunotherapies are mainly aimed to promote a CD8+ T cell response rather than a CD4+ T cell response as cytotoxic T lymphocytes (CTLs) can directly kill target cells. Recently, CD4+ T cells have received more attention due to their diverse roles in tumors and chronic viral infections. In antitumor and antichronic viral responses, CD4+ T cells relay help signals through dendritic cells to indirectly regulate CD8+ T cell response, interact with B cells or macrophages to indirectly modulate humoral immunity or macrophage polarization, and inhibit tumor blood vessel formation. Additionally, CD4+ T cells can also exhibit direct cytotoxicity toward target cells. However, regulatory T cells exhibit immunosuppression and CD4+ T cells become exhausted, which promote tumor progression and chronic viral persistence. Finally, we also outline immunotherapies based on CD4+ T cells, including adoptive cell transfer, vaccines, and immune checkpoint blockade. Overall, this review summarizes diverse roles of CD4+ T cells in the antitumor or protumor and chronic viral responses, and also highlights the immunotherapies based on CD4+ T cells, giving a better understanding of their roles in tumors and chronic viral infections.
Down‐regulation of Lon protease 1 lysine crotonylation aggravates mitochondrial dysfunction in polycystic ovary syndrome
Authors: Xie Yuan , Chen Shuwen , Guo Zaixin , Tian Ying , Hong Xinyu , Feng Penghui , Xie Qiu , Yu Qi 
Published: October 2023

AbstractPolycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine disorder, with metabolic abnormalities and ovulation disorders. The post‐translational modifications (PTMs) are functionally relevant and strengthen the link between metabolism and cellular functions. Lysine crotonylation is a newly identified PTM, the function of which in PCOS has not yet been reported. To explore the molecular mechanisms of crotonylation involved in the abnormalities of metabolic homeostasis and oocyte maturation in PCOS, by using liquid chromatography‐tandem mass spectrometry analysis, we constructed a comprehensive map of crotonylation modifications in ovarian tissue of PCOS‐like mouse model established by dehydroepiandrosterone induction. The crotonylation levels of proteins involved in metabolic processes were significantly decreased in PCOS ovaries compared to control samples. Further investigation showed that decrotonylation of Lon protease 1 (LONP1) at lysine 390 was associated with mitochondrial dysfunction in PCOS. Moreover, LONP1 crotonylation levels in PCOS were correlated with ovarian tissue oxidative stress levels, androgen levels, and oocyte development. Consistently, down‐regulation of LONP1 and LONP1 crotonylation levels were also observed in the blood samples of PCOS patients. Collectively, our study revealed a mechanism by which the decrotonylation of LONP1 may attenuate its activity and alter follicular microenvironment to affect oocyte maturation in PCOS.
Variation of the relative biological effectiveness with fractionation in proton therapy: Analysis of prostate cancer response
Authors: Pardo‐Montero Juan , Pombar Miguel , Gómez‐Caamaño Antonio , Giordanengo Simona , González‐Crespo Isabel 
Published: October 2023

AbstractBackgroundIn treatment planning for proton therapy a constant Relative Biological Effectiveness (RBE) of 1.1 is used, disregarding variations with linear energy transfer, clinical endpoint, or fractionation.PurposeTo present a methodology to analyze the variation of RBE with fractionation from clinical data of tumor control probability (TCP) and to apply it to study the response of prostate cancer to proton therapy.Methods and materialsWe analyzed the dependence of the RBE on the dose per fraction by using the LQ model and the Poisson TCP formalism. Clinical tumor control probabilities for prostate cancer (low and intermediate risk) treated with photon and proton therapy for conventional fractionation (2 Gy(RBE)×37 fractions), moderate hypofractionation (3 Gy(RBE)×20 fractions) and hypofractionation (7.25 Gy(RBE)×5 fractions) were obtained from the literature and analyzed aiming at obtaining the RBE and its dependence on the dose per fraction.ResultsThe theoretical analysis of the dependence of the RBE on the dose per fraction showed three distinct regions with RBE monotonically decreasing, increasing or staying constant with the dose per fraction, depending on the change of (α, β) values between photon and proton irradiation (the equilibrium point being at (αp/βp) = (αX/βX)(αX/αp)). An analysis of the clinical data showed RBE values that decline with increasing dose per fraction: for low risk RBE≈1.124, 1.119, and 1.102 for 1.82 Gy, 2.73 Gy and 6.59 Gy per fraction (physical proton doses), respectively; for intermediate risk RBE≈1.119 and 1.102 for 1.82 Gy and 6.59 Gy per fraction (physical proton doses), respectively. These values are nonetheless very close to the nominal 1.1 value.ConclusionsIn this study, we have presented a methodology to analyze the RBE for different fractionations, and we used it to study clinical data for prostate cancer and evaluate the RBE versus dose per fraction. The analysis shows a monotonically decreasing RBE with increasing dose per fraction, which is expected from the LQ formalism and the changes in (α, β) values between photon and proton irradiation. However, the calculations in this study have to be considered with care as they may be biased by limitations in the modeling assumptions and/or by the clinical data set used for the analysis.