bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valores intangibles del paisaje: alternativas de planificación territorial en bordes metropolitanos de tierras secas (Mendoza, Argentina)
Authors: Tonda María Marta , Martín Uceda Javier 
Published: October 2023

Las ciudades latinoamericanas crecen hacia las periferias, fragmentando el conector con su contexto natural. Un caso representativo es el área metropolitana de Mendoza (Argentina), con más del 60 % de la población provincial. Su piedemonte, entre el límite oeste del conglomerado metropolitano y los Andes, es uno de los ecosistemas más estudiados: por su fragilidad y amenaza; y la importancia funcional, ambiental y paisajística. Esta investigación incorpora el paisaje como elemento transversal en el ordenamiento del piedemonte, cartografiando los valores intangibles del paisaje, generalmente excluidos de las variables para la gestión territorial. Basados en principios de ciencia ciudadana y mapeo participativo georeferenciado (PPGIS), este enfoque recupera los intangibles del paisaje, por su capacidad de generar vínculos afectivos entre sociedad y entorno. Como resultado pueden obtenerse cartografías capaces de espacializar la dimensión perceptivo-emocional de las personas, para generar alternativas que permitan incluirlas como herramienta de gestión y planificación en perspectiva de paisaje.
The process of spatial frequency information in temporal synchrony perception for audiovisual stimuli
Authors: Takeshima Yasuhiro 
Published: October 2023

Abstract
Previous studies have shown that spatial frequency (SF) of visual stimuli alters the perceived timing of subjective simultaneity. However, these studies have been limited to the effects of a single SF component. This study measured and compared the points of subjective simultaneity (PSS) for audiovisual stimuli among low, high, and composited SF components. This experiment utilized a dual-presentation timing task and a ternary response format to eliminate response bias for simultaneity judgment. The results indicated that the PSS value of the composition-SF stimuli was medium between that of the low- and high-SF stimuli. The correlation coefficients showed that the PSS in composition-SF stimuli approximated that of high-SF stimuli higher than that of low-SF stimuli. Furthermore, this study more directly indicated that the difference of processing speed with SF modulated PSS values. Future studies are needed to confirm these findings via visual stimuli with a wider range of SF components.
Reconciling the ideals of open science with data privacy in the context of health research in Nigeria: A legal analysis
Authors: Adaji Aishatu Eleojo 
Published: October 2023

Abstract

Background The Nigerian Revised National Policy on Science, Technology and Innovation 2022 formally proposed the adoption of open science principles among researchers and all other stakeholders in Nigeria. With regard to health research, open science would allow the dissemination and sharing of scientific data and other research outputs among health researchers, thereby accelerating the scientific process and the development of innovative solutions for health challenges. However, in this context, the existing privacy and data protection rules can profoundly affect the adoption and sustainability of open science in Nigeria. This is because researchers rely heavily on accessing and sharing personal information and the biological samples of human subjects. Therefore, this study identifies and examines possible legal issues and challenges arising from the existing privacy and data protection rules as researchers adopt an open science approach to health research in Nigeria.
Methods This study adopts a qualitative approach, providing a legal analysis of existing national, regional and international instruments on privacy, data protection and health research in the context of open science in Nigeria. The study also draws on relevant research and non-research articles on open science, health research, privacy and data protection published in English. Searches for the articles were conducted on various sites through the Google search engine, using terms such as ‘sharing of data’, ‘data privacy’, ‘principles of data protection’, ‘open science’, etc.
Results/Conclusion The study finds that the right to privacy and data protection could affect the promotion, adoption and sustainability of open science among health researchers in Nigeria, as well as their ability to engage in open collaborative research with their peers in Africa and other jurisdictions. To prevent infringements of the privacy and data protection rules by researchers and thereby ensure the adoption of open science approaches in health research, the study further identifies various legal options for researchers, including using personal data or material transfer arrangements, which, among other things, require recipients or users of human data or biological samples to commit not to re-identify human subjects.
Using healthcare systems data for outcomes in clinical trials: Issues to consider at the design stage
Authors: Toader Alice-Maria , Campbell Marion K , Quint Jennifer K , Robling Michael , Sydes Matthew R , Thorn Joanna , Wright-Hughes Alexandra , Yu Ly-Mee , Abbott Tom E.F. , Bond Simon , Caskey Fergus J , Clout Madeleine , Collinson Michelle , Copsey Bethan , Davies Gwyneth , Driscoll Timothy , Gamble Carrol , Griffin Xavier L , Hamborg Thomas , Harris Jessica , Harrison David A , Harji Deena , Henderson Emily J , Logan Pip , Love Sharon B , Magee Laura A , O'Brien Alastair , Pufulete Maria , Ramnarayan Padmanabhan , Saratzis Athanasios , Smith Jo , Solis-Trapala Ivonne , Stubbs Clive , Farrin Amanda , Williamson Paula 
Published: October 2023

Abstract
Background
Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. The PRIMORANT study set out to determine when HSD are of sufficient quality and utility to replace bespoke outcome data collection, a methodological question prioritised by the clinical trials community.
Methods
The PRIMORANT study had three phases. First, an initial workshop was held to scope the issues faced by trialists when considering whether to use HSDs for trial outcomes. Second, a consultation exercise was undertaken with clinical trials unit (CTU) staff, trialists, methodologists, clinicians, funding panels and data providers. Third, a final discussion workshop was held, at which the results of the consultation were fed back, case studies presented, and issues considered in small breakout groups.
Results
Key topics included in the consultation process were validity of outcome data, timeliness of data capture, internal pilots, data-sharing, practical issues, and decision-making. A majority of respondents (n = 78, 95%) considered the development of guidance for trialists to be feasible. Guidance was developed following the discussion workshop, for the five broad areas of terminology, feasibility, internal pilots, onward data sharing, and data archiving.
Conclusions
We provide guidance to inform decisions about whether or not to use HSDs for outcomes, and if so, to assist trialists in working with registries and other HSD-providers to improve the design and delivery of trials.
Potential deficit irrigation adaptation strategies under climate change for sustaining cotton production in hyper–arid areas
Authors: Qi Zhiming , Chen Xiaoping , Dong Haibo , Gui Dongwei , Ma Liwang , Thorp Kelly R , Malone Robert , Wu Hao , Liu Bo , Feng Shaoyuan 
Published: October 2023

Abstract

Affected by climate change and elevated atmospheric CO2 levels, the efficacy of agricultural management practices is of particular concern in a hyper–arid area. Herein, the effects of future climate change on cotton (Gossypium hirsutum L.) yield and water use efficiency (WUE) was assessed under deficit irrigation strategies in China’s southern Xinjiang region. A previously calibrated and validated RZWQM2 model simulated cotton production for two time periods ranging between 2061–2080 and 2081–2100, under two automatic irrigation methods [crop evapotranspiration (ET–based) and plant available water (PAW–based)], factorially combined with four irrigation levels (100%, 80%, 60%, and 50%). Weather information was obtained from ten general circulation models, and three Shared Socioeconomic Pathways were tested. Simulation results showed that the irrigation strategy had a greater impact than climatic change on water use and crop production of cotton. Under climate change, both ET– and PAW–based irrigation methods with deficit irrigation showed a simulated decrease in water use and production of cotton compared to the baseline (1960–2019). Under future climate conditions, for a given irrigation level, PAW–based irrigation led to 35.3 mm–135 mm (7.4–53.9%) greater water use for cotton than did ET–based irrigation. For the 2061–2080 period, mean simulated seed cotton yields were 4.47, 3.69, 2.29 and 1.63 Mg ha–1 with the 100%, 80%, 60% and 50% ET–based irrigation protocols, respectively, and 4.46, 4.41, 3.85 and 3.34 Mg ha–1 with the equivalent PAW–based irrigation protocols. Similar yields were simulated for the 2081–2100 period. In addition, the 80% PAW–based or 100% ET–based irrigation protocols under future climate change provided the greatest cotton WUE in southern Xinjiang.
A height-renderable morphable tactile display enabled by programmable modulation of local stiffness in photothermally-active polymer
Authors: Yun Sungryul , Hwang Inwook , Mun Seongcheol , Youn Jung-Hwan , Kim Hyeong Jun , Park Seung Koo , Choi Meejeong , Kang Tae June , Pei Qibing 
Published: October 2023

Abstract
Reconfigurable tactile displays are currently being used to provide refreshable Braille information for the convenience of visually-impaired persons, while they deliver information limited to an alternative of Braille due to the difficulty in control of deformation height. Here, we present a photothermally active bilayered-polymer-based morphable tactile display that programmably generates tangible three-dimensional (3D) topologies with texture on a thin film surface. The morphable tactile display is composed of the heterogeneous polymer structure integrating stiffness-tunable polymer into light-absorbing elastomer, near infra-red light emitting diode (NIR-LED) array, and a small pneumatic chamber. In our tactile display, the topological expression is enabled by producing localized out-of-plane deformation, which is reversible, height-adjustable, and latchable in response to light-triggered stiffness-modulation at each target area under switching of a stationary pneumatic pressure. Moreover, the tactile display can express a spatial softness map on the latched topology by re-exposing the modulated NIR-LED light at target areas. The capability of the tactile display can contribute to opening a pathway to impart high-dimensional tactile information to electronic devices and even allow realistic interaction in augmented or virtual environments.
The Integrated Use of Some Common Agrochemicals and Different Entomopathogenic Nematode Species in The Control of Planococcus citri (Risso, 1813) (Hemiptera: Pseudococcidae)
Authors: Mamuk Nuray , Yüksel Ebubekir , Canhilal Ramazan 
Published: October 2023

Abstract
EPNs are an important component of integrated pest management(IPM) strategies and understanding their antagonistic and synergistic interactions with other biocontrol options is of crucial importance in promoting their use. In the current study, the antagonistic and synergistic effects of azadirachtin, sulfoxaflor, mineral oil, and thyme oil on the survival and pathogenicity of S. bicornutum, S. carpocapsae, H. indica, and H. bacteriaphora were investigated under controlled conditions(25 ± 1°C). The toxicity of agrochemicals to IJs was evaluated in 12-well plates and the IJs of each EPN species (5000IJs/50µL ddh2O) were exposed to the recommended field concentrations of agrochemicals. In the pathogenicity tests, the agrochemical and IJs solutions were applied to potato tubers at the concentration of 3000IJs/ml. The results revealed that all tested EPN species were quite compatible with azadirachtin, sulfoxaflor, mineral oil, and thyme oil and showed survival over 95% after 72 hours of exposure to tested agrochemicals. EPNs and mineral oil combination induced the highest efficacy on the Planococcus citri (Risso, 1813) (Hemiptera: Pseudococcidae) adults and all EPN species caused mortalities over 90% 72 hours after treatment except for S. bicornotum and mineral oil combination. The synergistic effect was observed in all combinations of EPNs with agrochemicals except for thyme oil. The results indicate that EPNs applied in combination with azadirachtin, sulfoxaflor, and mineral oil could provide more chances for successful control of P. citri. However, further studies are required to determine the antagonistic and synergistic effects of tested chemicals on EPNs in field conditions.
Morphometric network-based abnormalities correlate with psychiatric comorbidities and gene expression in PCDH19-related developmental and epileptic encephalopathy
Authors: Guerrini Renzo , Lenge Matteo , Balestrini Simona , Napolitano Antonio , Mei Davide , Conti Valerio , Baldassarri Giulia , Trivisano Marina , Pellacani Simona , Macconi Letizia , Longo Daniela , Espagnet Maria Camilla Rossi , Cappelletti Simona , d'Incerti Ludovico , Barba Carmen , Specchio Nicola 
Published: October 2023

Abstract
Protocadherin-19 (PCDH19) developmental and epileptic encephalopathy causes an early-onset epilepsy syndrome with limbic seizures, typically occurring in clusters and variably associated with intellectual disability and a range of psychiatric disorders including hyperactive, obsessive-compulsive and autistic features. Previous quantitative neuroimaging studies revealed abnormal cortical areas in the limbic formation (parahippocampal and fusiform gyri) and underlying white-matter fibers. In this study, we adopted morphometric, network-based and multivariate statistical methods to examine the cortex and substructure of the hippocampus and amygdala in a cohort of 20 PCDH19-mutated patients and evaluated the relation between structural patterns and clinical variables at individual level. We also correlated morphometric alterations with known patterns of PCDH19 expression levels. We found patients to exhibit high-significant reductions of cortical surface area at a whole-brain level (left/right pvalue=0.045/0.084), and particularly in the regions of the limbic network (left/right parahippocampal gyri pvalue=0.230/0.016; left/right entorhinal gyri pvalue=0.002/0.327), and bilateral atrophy of several subunits of the amygdala and hippocampus, particularly in the CA regions (head of the left CA3 pvalue=0.002; body of the right CA3 pvalue=0.004), and differences in the shape of hippocampal structures. More severe psychiatric comorbidities correlated with more significant altered patterns, with the entorhinal gyrus (pvalue=0.013) and body of hippocampus (pvalue=0.048) being more severely affected. Morphometric alterations correlated significantly with the known expression patterns of PCDH19 (rvalue=-0.26, pvalue=0.034). PCDH19 encephalopathy represents a model of genetically determined neural network based neuropsychiatric disease in which quantitative MRI-based findings correlate with the severity of clinical manifestations and had have a potential predictive value if analyzed early.
Association Between Serum IgG Concentrations and Prognosis in IgA Nephropathy
Authors: Fei Tang , Ricong Xu , Li Fan , Haofei Hu , Yuan Cheng , Rong Cao , cai Tao , Xueqing Yu , Wei Chen , Qijun Wan 
Published: October 2023

Abstract

Objective:
This study was aimed to assess the relationship between serum IgG (SIgG) level and the clinical, pathological phenotype of IgA nephropathy (IgAN), and to determine the role of SIgG level in the progression and prognosis of IgAN.
Methods:
It was a multi-center retrospective cohort study, patients with biopsy proven primary IgAN who were recorded in the Chinese IgA Nephropathy Information Registration System between April 1996 and September 2018 were included. Patients were divided into 3 groups according to the baseline tertiles of sIgG : ≤9.50g/L, 9.51 to 11.99 g/L, and≥ 12.00 g/L. The endpoint events were defined as doubled serum creatinine level from baseline, or end-stage renal disease (ESRD).
Results:
A total of 1976 IgAN patients were included in this study. At baseline, mean age, eGFR, and serum IgG levels were 34.84 ± 10.75years, 80.38 ± 33.09﻿mL/min/1.73 m2, and 10.82 ± 3.23g/L, respectively. During a median of ﻿ 33months of follow-up, endpoint events were observed in 232 (11.74%) patients. After adjustment for demographic and IgAN-specific covariates and treatments, patients with a higher tertile of SIgG was associated with an decreased risk of developing poor renal outcomes from the Cox proportional hazards models.
Conclusion:
The higher level of sIgG at diagnosis is associated with better clinicopathologic features and renal outcomes, and may portend better renal survival in IgAN patients.
Astragaloside IV attenuates glucocorticoid-induced osteoclastogenesis and bone loss via the MAPK/NF-κB pathway
Authors: Guo Chun , Li Yangyang , Yang Ruijuan , Xie Mingzhang , Chen Xiangfeng , Che Zhiqun , Wang Zhixia , Zhong Bin , Luo Yanhong , Leng Xiaomin 
Published: October 2023

Abstract
Background Astragaloside IV (AS-IV) is a bioactive saponin extracted from astragalus membranaceus, and it is reported to promote osteoblast differentiation while inhibiting osteoclastogenesis. However, the mechanism of AS-IV in glucocorticoid-induced osteoclastogenesis (GIO) remains undetermined. Herein, we examined the influence of AS-IV on GIO and bone loss.
Methods RAW264.7 cells were incubated with dexamethasone (Dex) alone or Dex and receptor activator of nuclear factor-B ligand (RANKL) (Dex and RANKL) for 2 days, and then treated with Dex or Dex and RANKL through AS-IV for the timeframes indicated. Following, mice were intraperitoneally administered with an intermediate-acting glucocorticoid, methylprednisolone (MP), or MP and AS-IV for 6 weeks.
Results AS-IV significantly decreased Dex-induced osteoclast nucleus and area, however, it did not impact the number of Dex-induced osteoclasts in RAW264.7 cells. AS-IV also significantly decreased the osteoclastic marker protein expressions in Dex-induced RAW264.7 cells with concentration of dose dependent fashion. Additionally, AS-IV promoted p38 phosphorylation (p-) and p-p65 translocation to the nucleus, while inhibiting phosphorylation of extracellular signal-regulated kinase (ERK) (p-ERK) and inhibitor of Nuclear factor κB (NF-κB) (p-IκB) levels. However, the AS-IV-mediated action on p-MAPK, p-NF-κB, and osteoclastic marker expressions were reversed by MAPK or IκB inhibitor in Dex-induced RAW264.7 cells. Furthermore, our in vivo evaluation revealed that AS-IV also attenuated the MP-mediated bone loss, and suppressed osteoclastogenesis.
Conclusions This study demonstrates that AS-IV inhibits GIO and attenuates bone loss via the MAPK/NF-κB pathway. This also suggested that AS-IV could be a potential promising therapeutic agent for glucocorticoid-triggered bone loss.
“You don’t get resilience overnight”: A Grounded theory framework of the A-R-C Sporting Resilience Development
Authors: Gupta Sahen , McCarthy Paul 
Published: October 2023

Abstract

Resilience in sport is growing as a topic of investigation but little is known about how resilience develops in athletes. This study explored sporting resilience development in elite athletes over time using grounded theory. Participants from diverse cultural contexts were screened using Brief Resilience Scale (Smith et al., 2008). Sample included 10 competitive-elite athletes (5 men & women) who scored high, competing in individual/team sports. Experiential life-story interviews on sporting resilience development over time was conducted. Grounded theory was employed across ideation, data collection and analysis. Methodological rigour was established by incorporating checks and outcomes were judged using quality criteria. Findings are synthesised into A-R-C Development Model of sporting resilience indicating that antecedent protective factors (A) enable the engine of sporting resilience (R) which through metacognition-emotion-behaviour produces consequences (C) of positive adaptation or critical adaptation failure. Emergent theory provides an understanding of how sporting resilience develops over time in competitive-elite athletes.
Production System, and Egg Quality of Village Chicken Reared Under Traditional Management System in Angecha And Damboya Districts of Kembata Tembaro Zone, Southern Ethiopia
Authors: Amanuel Eskindir , Amanuel Desalegn , Shanku Edao 
Published: October 2023

Abstract
The study was conducted in two selected districts of Kembata Tembaro Zone, Southern Ethiopia with an aim of assessing the production system, performance and selected egg quality of village chicken reared under traditional management system. Multi-stage sampling technique was used to select representative sample and one hundred eight six respondents (186) were interviewed with structured questionnaire. The data were organized and analyzed by using SPSS and SAS.
The mean of Eggs per clutch per hen, Age at first lay, and number of clutches per hen/year were 15.82±0.54, 7.08±0.25, 5.26±0.25 and Age of sexual Maturity (Male=7.67±0.306and female=8.13±0.301), respectively. The predominate breed is exotic (59.6%) with village chicken production system. 50.55% of the respondents keep chicken in Perch at one corner in common house, 45.70% were practicing of isolation of sick birds from healthy to prevent disease transmission. The mean of eggs incubated, hatched and hatchability of percentages were (14.5±0.55, 12.5±0.57 and 80.5), respectively. The study revealed that 40.32, 26.2 and 17.32% of respondent’s rear chicken for sale, home consumption and non-defined purpose, respectively. The highest percentage of the interviewed respondent’s utilization of eggs were for selling purpose 30.1% (Mid-land) and 31.7% (High land). Regarding egg storage condition in high land and mid land agro ecology about 21.5% and 18.3% of the respondents store their eggs in inside cold container respectively. The major constraints of chicken production in the study areas were prevalence of disease, high chick mortality, predator attack, shortage of feed and grains and lack of parent stock, respectively. The most economically important disease that attacks chicken was Newcastle disease which is locally known as “Kenbesha” in the study areas. All egg quality parameters were statistically similar (P>0.05) among the agro ecology except significant difference (P≤0.05) on egg yolk height and albumen height. Shell thickness was comparable to the acceptable egg shell thickness to withstand egg breakage. The yolk index values of the eggs obtained from both agro ecology ranged from 0.54–0.56. The HU value that determine the quality of albumen was within the range of 70-100 set for good egg quality. Therefore, efforts should be geared to alleviate constraints like prevalence of disease, High chick mortality, predator attack, shortage of feed and lack of parent stock hampering chicken production, training of smallholder farmers on chicken housing practices and further research was required on external and internal egg quality determination under different production system.