bluuebunny/crossref_metadata_2025_split huggingface dataset:
"EN PRENSA" Identificación de ecotipos de Agave maximiliana Baker y su diferencia en la producción de biomasa y azúcares reductores totales "EN PRENSA"
Authors: Cachúa-Torres Alfredo , Andrade González Isaac , Chávez Rodríguez Alejandra , López Muraira Irma Guadalupe 
Published: January 2025

La raicilla es un destilado, producto del fermento de jugos de piñas de Agave maximiliana, que se encuentras aun en forma silvestre en las Sierras Occidental del Estado de Jalisco. Por lo que el objetivo de este trabajo consistió en la identificación de los diferentes ecotipos de Agave maximilina existente en la sierra Occidental del Estado de Jalisco, con su diferenciación en la producción de biomasa y azúcares reductores. El trabajo se desarrolló en el 2020 en Mascota, Jalisco a 195 km al poniente de Guadalajara. Se realizaron entrevistas semiestructuradas con productores y maestros raicilleros y se recabaron los etnotaxa de los distintos ecotipos. Se cuantificó la producción de biomasa llevando a cabo la colecta de cuatro ejemplares por año de crecimiento desde 2 a 8 años por ecotipo, pesando cada piña dende cada peso represento una repetición del ecotipo. La cuantificación de los azúcares reductores se realizó por la técnica DNS. Se identificaron 7 variantes, en los cuales la biomasa entre ellos no muestra diferencia estadística los primeros 3 años. A los 8 años el rendimiento promedio varió de 14.25 kg hasta 47.87 kg según el ecotipo. La producción de azúcares reductores mostró rangos de 32% hasta 83%. A. maximiliana manifiesta alta variabilidad genética intraespecífica reflejándose en tamaño y peso de piñas entre y dentro de los ecotipos, así como también para la producción de azúcares reductores totales. En el presente estudio el mejor ecotipos según su producción de biomasa y azúcares reductores totales fue los ecotipo denominados Típica y Costillona
Analysis of functional disorders in oncohematological diseases survivours1
Authors: Klyut A. S. , Kharbediya V. Kh. , Abrahamyan D. G. , Peryatinskiy A. V. , Glazyrina A. A. , Petryaykina E. E. 
Published: January 2025

Thanks to modern approaches to the treatment of children with oncohematological diseases, an increase in overall and relapse-free survival is noted. However, in the process of therapy of a malignant disease, a number of complications may arise, leading to the development of concomitant pathology with various functional disorders.The article presents a broad spectrum of morphologic and functional disorders in 52 patients completed an oncohematological disease treatment. It is justified the use of physical and psychological methods of rehabilitation for the most effective prophylaxis and treatment.
Neoadjuvant chemotherapy and pathological complete response in hormone-positive HER2-negative breast cancer: influence of progesterone receptor expression, tumor grade and Ki-67
Authors: Zanozina E. A. , Bolotina L. V. , Rasskazova E. A. , Sipki V. N. , Maksimov K. V. , Zikiryakhodzhaev A. D. 
Published: January 2025

Aim. To study the role of progesterone receptor expression, tumor grade and Ki-67 level as possible predictors of pathological complete response (pCR) to neoadjuvant chemotherapy in patients with stage IIA–IIB (cT1–2N1, cT2–3N0M0) breast cancer of hormone-positive HER2-negative subtype.Materials and methods. We retrospectively analysed the efficacy of neoadjuvant chemotherapy (4AC+12P/4T) in 100 patients with cancer stages IIA–IIB (cT1–2N1, cT2–3N0M0) of hormone-positive HER2-negative subtype treated at the P.A. Hertsen Moscow Oncology Research Institute from 2013 to 2022. The pathological response to neoadjuvant chemotherapy depending on the level of progesterone receptor expression, tumour grade (G) and tumour proliferation index (Ki-67) were evaluated.Results. Pathological complete response was achieved in 12 of 100 patients. The progesterone receptor expression ≤3 Allred pCR scores were found in 16.1 % (5/31) of patients, whereas with progesterone receptor >3 scores in 10.1 % (7/69) (odds ratio 1.703; 95 % confidence interval (CI) 0.495–5.860; p = 0.507). Patients with high tumour grade (G3) achieved pCR in 12.1 % (4/33) cases and with G2 – in 11.9 % (8/67) (odds ratio 1.017; 95 % CI 0.283–3.658; p = 1.000). With the Ki-67 levels ≥50 % pCR was achieved in 14.6 % (7/48) cases compared to 9.6 % (5/52) with Ki-67 levels <50 %(odds ratio 1.605; 95 % CI 0.473–5.445; p = 0.544). The Ki-67 threshold for achieving pCR was 70 % (area under the ROC curve 0.663 ± 0.090; 95 % CI 0.486–0.840; p = 0.068) and for progesterone receptors was 3 points (area under the ROC curve 0.625 ± 0.080; 95 % CI 0.467–0.782; p = 0.156).Conclusion. This analysis highlights the importance of considering all clinical and morphological characteristics of the tumour when planning the scope of treatment for hormone-positive HER2-negative breast cancer. The results obtained may serve as a basis for a more personalised therapeutic approach.
What we know about the new coronavirus infection in cancer patients
Authors: Feoktistova P. S. , Azarova E. A. , Volkova D. M. , Emelyanova A. A. , Iglamov A. K. , Igumnova A. N. , Isyangulova A. Z. , Mazhbich M. S. , Menshikov K. V. , Murzina Yu. I. , Polyakov A. A. , Saevets V.  V. , Samoilenko I. V. , Stukan A. I. , Tonenkova E.  E. , Khryashchev A. A. , Fateeva A. V. , Chebykina I. S. , Kuzmina E. S. , Fedyanin M.  Yu. , Tryakin A. A. , Karaseva V. V. , Khailenko V. A. , Zhukova L. G. , Tjulandin S.  A. 
Published: January 2025

The article presents data from a retrospective study of COVID-19 outcomes in cancer patients from 24 regions of the Russian Federation.The study included 1,055 patients who had a Coronavirus disease 2019, including 451 (42.7 %) men and 604 (57.3) women. The mean age was 58.7 years (29–90); 108 (10.2 %) patients were diagnosed with various comorbidities. 627 (59.4 %) were receiving antitumor drug therapy at the time of diagnosis of COVID-19, and 332 (31.5 %) received antitumor chemotherapy.Most patients had asymptomatic or mild COVID-19: asymptomatic in 205 (19.4 %) patients, and mild — in 517 (49.0 %) patients. Moderate / severe COVID-19 was observed in 268 (25.4 %) patients, while severe / critical COVID-19 was diagnosed in 65 (6.2 %). 1204601776 25 (2.4 %) patients died after COVID-19. The average age of cancer patients who died was 66.3 years (31–84). Among the deceased patients, 16 (64.0 %) were women and 9 (36.0 %) were men. To determine the factors increasing the risk of death in cancer patients we performed univariate and multivariate analyses. Conclusions: based on the presented data, the probability of death from COVID-19 was associated with the anti-tumor therapy administered during the disease. This conclusion obliges us to stop antitumor chemotherapy during the COVID-19 disease.
Cross-sectional study of treatment approaches of luminal HER2negative metastatic breast cancer in real practice in Moscow
Authors: Zhukova L. G. , Grechukhina K. S. , Khatkova E. I. , Akopyan A. A. , Volkonskii M. V. , Kalistratova N. Yu. , Kramskaya L. V. , Krivolapova L. V. , Pokataev I. A , Romanchuk O. V. , Filippova V.  M. , Yurchenkov A. N. 
Published: January 2025

Introduction: The systemic therapy of patients with metastatic luminal HER2‑negative breast cancer (mBC) in‑ cludes various options, which can be fundamentally divided into endocrine therapy and chemotherapy. According to the Clinical Guidelines, both international and Russian, the “gold standard” of the 1st line therapy for patients with metastatic luminal HER2‑negative breast cancer (mBC) is a combination of cyclindependent kinase inhib‑ itors 4 / 6 (iCDK4 / 6) with endocrine therapy (ET). However, until recently we did not have complete data on the characteristics of the Russian population of patients with luminal HER2‑breast cancer, their treatment options, and the results of this therapy.Aim: To analyze the patients’ profile and current treatment approaches for patients with luminal HER2 mBC in routine clinical practice in Moscow.Materials and methods: The study was performed as an observational, crosssectional and retrospective study. The data of 2,500 patients from medical institutions in Moscow who received systemic therapy for luminal HER2 mBC in AugustOctober 2021 were analyzed.Results: The largest number of patients received iCDK4 / 6 + ET in the first and second lines: 69.0 % and 52.0 %, respectively. In the first line, 54.6 % of patients received ribociclib, 43.1 % palbociclib and 2.3 % abemaciclib. In the second line, 50.6 % of patients received ribociclib, 47.8 % palbociclib and 1.6 % abemaciclib. As the pretreatment of patients increased, preference was given to other treatment methods, therefore the proportion of combined ET decreased to 34.0 % in the third line and 25.0 % in the fourth and subsequent lines.Conclusion: The data obtained indicate that the appointment of iCDK4 / 6 + ET is made in accordance with the Clinical Guidelines for the treatment of breast cancer of the Ministry of Health of the Russian Federation from 2021 and the preferred firstline treatment option for patients with luminal HER2 mBC in Moscow is combined endocrine therapy.
Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity
Authors: Nohara Junsuke , Evangelous Tyler , Berry Madison , Beck Whitney , Mudrak Sarah , Jha Shalini , Reeves R. Keith , Wiehe Kevin J. , Pollara Justin , Tomaras Georgia , Bradley Todd , Ferrari Guido 
Published: January 2025

Background: Antibody-dependent cell-mediated cytotoxic (ADCC) response mediated by natural killer (NK) cells correlates with decreased infection risk in studies involving simian immunodeficiency virus (SIV)/simian-human immunodeficiency virus (SHIV), and human immunodeficiency virus (HIV) vaccine candidates. Currently, the heterogeneities of the functional subset of rhesus macaque natural killer (RMNK) cells are under-characterized.
Method: We engaged the RMNK cells with ADCC-mediating anti-HIV-1 monoclonal antibodies (ADCCAbs) or anti-CD16 antibodies and used CD107a expression as the surrogate marker for RMNK cells actively involved in ADCC. CD107a+ and CD107a– populations were analyzed individually using single-cell RNA sequencing.
Results: Subsets of CD107a+ RMNK cells produced more chemokines than the others, suggesting that these cells not only eliminate infected cells but also provide immunoregulatory signals and potentially curb HIV-1 replication. Crosslinking of Fc gamma receptor IIIa via anti-CD16 antibodies resulted in a significantly higher percentage of degranulating cells than via ADCCAbs. However, the magnitude of degranulation and chemokine production was reduced by 6- to 30-fold.
Conclusion: The quality and quantity of receptor engagement are important determinants of achieving an optimal level of the RMNK response.
Hypervirulent Klebsiella pneumoniae (hvKp): Overview, Epidemiology, and Laboratory Detection
Authors: Al Ismail Dania , Campos-Madueno Edgar I. , Donà Valentina , Endimiani Andrea 
Published: January 2025

Klebsiella pneumoniae (Kp) is a Gram-negative pathogen responsible for both hospital- and community-acquired infections. Kp is classified into 2 distinct pathotypes: classical K. pneumoniae (cKp) and hypervirulent K. pneumoniae (hvKp). First described in Taiwan in 1986, hvKp are highly pathogenic and characterized by unique phenotypic and genotypic traits. The hypermucoviscous (hmv) phenotype, generally marked by overproduction of the capsule, is often associated with hvKp, although recent studies show that some cKp strains may also have this characteristic. Furthermore, hvKp can cause severe community-acquired infections in healthy people and have been associated with metastatic infections such as liver abscess, meningitis, and endophthalmitis. HvKp are increasingly being reported in hospital-acquired settings, complicating treatment strategies. In particular, while hvKp have historically been antibiotic-susceptible, multidrug-resistant (MDR) strains have emerged and pose a significant public health threat. The combination of high virulence and limited antibiotic options demands further research into virulence mechanisms and rapid identification methods.
This review discusses the epidemiology of hvKp and their virulence factors, highlighting the importance of phenotypic and non-phenotypic tests, including next-generation molecular diagnostics, for the early detection of hvKp.
Outcomes of Calcaneal Lengthening Osteotomy in Ambulatory Patients with Cerebral Palsy and Planovalgus Foot Deformity
Authors: Park Byoung Kyu , Abdel-Baki Sharkawy Wagih , Rhee Isaac , Park Kun-Bo , Park Hoon , Kim Hyun Woo 
Published: January 2025

Background:
To date, no studies have evaluated the longevity of calcaneal lengthening osteotomy (CLO) in patients with cerebral palsy (CP) and pes planovalgus. This study aimed to explore the changes in foot alignment following CLO in patients with CP, utilizing both radiographic evaluations and dynamic foot-pressure assessments.

Methods:
A retrospective study of 282 feet in 180 ambulatory patients was performed. The mean patient age at the surgical procedure was 8.9 ± 2.6 years. The mean follow-up period was 8.0 ± 4.3 years, and the mean age at the final follow-up 16.9 ± 4.4 years. Weight-bearing radiographs at 3 separate time points (before the surgical procedure, 6 months postoperatively, and at the final follow-up) were used. The feet were classified as corrected, undercorrected, or overcorrected on the basis of the radiographic parameters.

Results:
At the final follow-up, we classified 98 feet (34.8%) as corrected, 58 (20.6%) as undercorrected, and 126 (44.7%) as overcorrected. Foot-pressure analysis demonstrated that the undercorrected feet had higher relative vertical impulses in the medial forefoot and medial midfoot than in the other groups, whereas the overcorrected feet had higher impulse in the lateral midfoot. There were no significant differences in preoperative radiographic parameters between the 3 groups, except for the calcaneal pitch angle. At 6 months after the surgical procedure, we classified 181 feet (64.2%) as corrected, 58 (20.6%) as undercorrected, and 43 (15.2%) as overcorrected. However, 53.6% of initially corrected feet changed to being undercorrected or overcorrected during further follow-up, 43.1% of the undercorrected feet became corrected or overcorrected, and 16.3% of the overcorrected feet became corrected. A younger age at the surgical procedure and lower naviculocuboid overlap at 6 months after the surgical procedure were the risk factors for overcorrection.

Conclusions:
Although CLO is an effective method for correcting planovalgus foot deformities and enhancing foot-pressure distribution, the extent of correction observed early after the surgical procedure was not necessarily sustained over the follow-up period in individuals with CP. Furthermore, our findings highlight a noticeable tendency toward the overcorrection of the deformity, as evidenced by increased pressure exerted on the lateral midfoot.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Lisfranc Fracture-dislocation With Extensor Hallucis Brevis Tendon Interposition
Authors: McCahon Joseph , Denmark Grant , Bridges Tiffany N. , Trionfo Arianna 
Published: January 2025

Case:
A 14-year-old adolescent girl sustained a Lisfranc fracture-dislocation with an interposed extensor hallucis brevis (EHB) tendon. Following multiple failed attempts at closed reduction in both the emergency department and the operating room, the patient was treated in a staged manner with temporizing closed reduction and percutaneous pinning in improved alignment, followed by definitive open reduction and internal fixation once soft tissues allowed.

Conclusions:
Anatomic reduction and stable fixation of Lisfranc injuries is vital to regain stability and reduce the risk of midfoot arthritis and collapse. To our knowledge, this is the only case report describing the EHB tendon as a block to reduction of a Lisfranc fracture-dislocation.
Navigating life Post-Cancer Diagnosis in women: Symptom Clusters and Influencing Factors
Authors: Nguyen Huyen Thi Hoa , Duong Duc Trung , Tran Tran Ngoc , Nguyen Anh Chau , Hac My Huyen , Do Quyen Thu , Tran Thanh Hai , Tran Duc Quang , Hoang Huong Thi Xuan 
Published: January 2025

Abstract

Aims: 1) To identify symptom clusters in Vietnamese women with cancer and 2) to examine the factors influencing those identified clusters.
Method: This cross-sectional study was conducted in 5 hospitals across Vietnam from September to December 2023. A total of 217 valid data sets from women with cancer were included. The symptom clusters were identified by exploratory factor analyses.
Results: Fatigue and appetite loss were recognized as the most common symptoms. The exploratory factor analysis showed two distinct groups of factors, occupying 54.66% of total variance: fatigue, appetite loss, pain, sleep issues, hair loss, nausea, and sexual issues (Factor 1 – physical cluster) and mood issues, personal stress, depression, and anxiety (Factor 2 – psychological cluster). In terms of factors influencing two clusters, smoking demonstrated a marginally non-significant negative association with Factor 1 - physical health (R2=1.44%), while physical activity illustrated a significant negative association with Factor 2 - mental health (R2= 7.25%).
Conclusions: The physical and psychological symptom clusters underlay symptom experiences complexity. Tailored interventions from healthcare providers are required to enhance patients’ outcomes and quality of life.
Assessing the local impacts of increasing high-temperature extremes at Euro-Mediterranean airports on aircraft takeoff performance
Authors: Gallardo Victoria , Sánchez-Gómez Emilia , Riber Eleonore , Bonnet Serge , Jiménez-Guerrero Pedro 
Published: January 2025

Abstract

The increasing intensity and frequency of high-temperature extreme events due to climate change negatively affects aircraft takeoff performances. Warmer near-surface air temperatures result in lower aircraft lift and engine thrust, thereby reducing the aircraft’s weight-lifting capacity at takeoff. This study evaluates the potential impact of the future changes in high-temperature extremes on the aircraft’s Maximum Takeoff Weight (MTOW) at the airports in the Euro-Mediterranean region —a climate change hotspot. Major, regional and small airports are considered. First, the evolution of high-temperature extremes at the airports is assessed using climate observations for the baseline period 1961-1990, and future climate projections under the most severe climate change scenario RCP8.5 for the periods 2021-2050 (near-term future) and 2041-2071 (medium-term future). Simulations from both Regional and Global Climate Models (RCMs and GCMs) belonging to the Euro-CORDEX and CMIP5 frameworks, respectively, are considered in a Multi-Model Ensemble approach. Second, the MTOW is obtained by combining the climate data with aircraft technical data and applying an empirical law from the aeronautical sector, which relates the MTOW to
the ambient temperature. The induced changes in MTOWare estimated for widebody, narrow-body and small regional aircrafts, widely used in global commercial aviation. Results indicate that most of Euro-Mediterranean airports could experience a decrease in MTOW, as early as the next three decades, at least for one aircraft type. For wide-bodies and narrow-bodies, these reductions are of the order of tons, according to the MME means of the RCMs and the GCMs: up to 7 tons in the near term and up to 11 tons in the medium term. Regional aircrafts would experience MTOW reductions of hundreds of kgs. This could have a socio-economic impact, either from possible weight restrictions, flight delays or cancellations. The results of this study could guide the design of adaptation strategies at the European level, aimed at building a climate change-resilient aviation network and ensuring that European aviation will be prepared for future extreme heat events.
Facilitators and Barriers for a Stepped-Care Approach to promote Return to Work of Employees with Distress. A Multi-Perspective Qualitative Study
Authors: Lettinga Hanneke A. M. , Oostrom Sandra H. van , Zijlstra Hendrika P. , Anema Johannes R. , Proper Karin I. 
Published: January 2025

Abstract

Purpose. A stepped-care approach, beginning with a low-intensity e-Health program followed by a high-intensity Participatory Approach led by a return-to-work (RTW) coordinator is a promising intervention to promote RTW of employees on sick leave with distress. As this approach is new, determinants of its successful implementation remain unknown. This study aimed to identify the expected facilitators and barriers for a stepped-care approach to promote RTW of employees with distress, from the perspective of employees, employers and occupational physicians.
Methods. A qualitative study was performed consisting of individual semi-structured interviews with 10 employees, 5 supervisors and two focus groups with (in total) 18 occupational physicians. The verbatim transcripts were first thematically coded, final themes and names were constructed based on The Consolidated Framework for Implementation Research (CFIR).
Results. Themes within the CFIR domains “innovation”, “outer setting”, “inner setting” and “characteristics of the individual” were identified. From all three perspectives, identified facilitators were the tailored program, enabling adjustment of tasks to the need of the employee and the RTW-coordinator to stimulate a good communicative relationship between employee and supervisor. Barriers identified were the timing of the stepped-care approach, the possibility of having too many services deployed at the same time for the employee, and low digital skills .
Conclusion. Successful implementation of the stepped-care approach requires attention to all four CFIR domains. The possibility to tailor the intervention, supporting communication and balancing service delivery are important to facilitate the implementation of the stepped-care approach.
Trial Registration: ISRCTN: 90663076. Registered on 5 October 2023.
Simultaneous topology and path optimization for 3D concrete printing based on discrete frame structures
Authors: Liao Minmao , Sun Xiao , Chen Zhaohui 
Published: January 2025

Abstract

A novel methodology is introduced for simultaneously optimizing both the structural topology and printing paths in 3D concrete printing (3DCP). Drawing inspiration from the inherent geometric characteristics of 3DCP, this approach anchors its optimization framework within discrete frame structures. Beyond conventional frame topology optimization, we introduced the concept of simultaneous path optimization, bridging the gap between optimal design conception and its seamless realization in manufacturing. Leveraging the mechanical anisotropy inherent to 3DCP, we strategically orient the printing directions such that each frame member is printed along its longitudinal axis, optimizing for strength and material efficiency. To ensure direct printability, we impose constraints whereby the width of each member must be an integer multiple of the nozzle size, and the printing path must traverse continuously, covering the entire design without any intersections or overlaps. An Eulerian circuit, rooted in graph theory, fulfills part of these requirements, with additional constraints introduced to rigorously eliminate intersections and overlaps. The comprehensive simultaneous optimization problem is then formulated as a Mixed-Integer Linear Program (MILP), which is readily solvable. The application of this methodology to various test problems has yielded successful outcomes, demonstrating the efficacy and practicality of our approach in achieving simultaneous optimization of both structural topology and printing paths in 3DCP.